# --- full sequence ---- --- best 1 domain ---- --- domain number estimation ---- # target name accession query name accession E-value score bias E-value score bias exp reg clu ov env dom rep inc description of target #------------------- ---------- -------------------- ---------- --------- ------ ----- --------- ------ ----- --- --- --- --- --- --- --- --- --------------------- DUF5314 PF17241.2 EDO14287.1 - 6.3e-51 172.8 0.0 7.5e-51 172.6 0.0 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5314) Hexapep PF00132.24 EDO14288.1 - 2.9e-09 36.3 5.8 3.2e-06 26.7 2.3 3.5 3 1 0 3 3 3 2 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 EDO14288.1 - 0.54 10.1 5.9 20 5.1 4.3 3.5 3 1 0 3 3 3 0 Hexapeptide repeat of succinyl-transferase GN3L_Grn1 PF08701.11 EDO14289.1 - 1.8e-23 82.4 16.7 4.1e-23 81.3 16.7 1.6 1 0 0 1 1 1 1 GNL3L/Grn1 putative GTPase GTP_EFTU PF00009.27 EDO14289.1 - 0.03 13.8 0.5 0.064 12.8 0.0 1.7 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EDO14289.1 - 0.067 13.3 0.0 0.15 12.1 0.0 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase Nuc_deoxyri_tr2 PF15891.5 EDO14289.1 - 0.093 13.1 0.1 0.26 11.6 0.0 1.8 2 0 0 2 2 2 0 Nucleoside 2-deoxyribosyltransferase like Dynamin_N PF00350.23 EDO14289.1 - 0.18 11.8 3.6 0.52 10.4 3.6 2.0 1 1 0 1 1 1 0 Dynamin family Flocculin PF00624.18 EDO14290.1 - 1.1e-177 576.0 442.8 7.4e-14 51.7 26.1 13.6 14 0 0 14 14 14 13 Flocculin repeat PDR_assoc PF08370.11 EDO14290.1 - 3.4e-25 87.6 38.1 2 8.2 0.1 13.2 13 0 0 13 13 13 13 Plant PDR ABC transporter associated SDH_C PF18317.1 EDO14290.1 - 3.9e-07 29.7 20.3 1.6e+02 2.2 0.0 12.5 13 0 0 13 13 13 0 Shikimate 5'-dehydrogenase C-terminal domain RVT_1 PF00078.27 EDO14291.1 - 3e-18 66.2 0.1 2e-16 60.2 0.1 2.7 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DNA_pol_viral_C PF00336.18 EDO14291.1 - 0.0087 15.5 0.0 0.022 14.2 0.0 1.6 1 0 0 1 1 1 1 DNA polymerase (viral) C-terminal domain RVT_2 PF07727.14 EDO14291.1 - 0.021 14.5 0.7 0.35 10.5 0.7 2.3 1 1 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) OmpH PF03938.14 EDO14291.1 - 4.6 7.6 36.0 1.8e+04 -10.6 36.0 2.8 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF5314 PF17241.2 EDO14292.1 - 2.5e-80 268.8 0.0 2.9e-80 268.6 0.0 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5314) Lge1 PF11488.8 EDO14293.1 - 2.2e-19 69.4 6.5 2.2e-19 69.4 6.5 2.1 2 0 0 2 2 2 1 Transcriptional regulatory protein LGE1 Spt20 PF12090.8 EDO14293.1 - 0.14 11.7 22.0 0.31 10.6 22.0 1.5 1 0 0 1 1 1 0 Spt20 family Band_3_cyto PF07565.13 EDO14293.1 - 0.5 10.1 4.0 0.31 10.8 1.8 1.6 2 0 0 2 2 2 0 Band 3 cytoplasmic domain COX14 PF14880.6 EDO14293.1 - 1.2 9.0 3.7 2.8 7.9 3.7 1.6 1 0 0 1 1 1 0 Cytochrome oxidase c assembly Activator_LAG-3 PF11498.8 EDO14293.1 - 2.1 7.2 27.8 3.1 6.6 27.8 1.3 1 0 0 1 1 1 0 Transcriptional activator LAG-3 Med3 PF11593.8 EDO14293.1 - 4.6 6.3 19.5 10 5.2 19.5 1.6 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Presenilin PF01080.17 EDO14293.1 - 5.2 5.7 8.8 8.1 5.1 8.8 1.3 1 0 0 1 1 1 0 Presenilin KcnmB2_inactiv PF09303.10 EDO14295.1 - 0.15 11.9 0.6 0.15 11.9 0.6 2.2 2 0 0 2 2 2 0 KCNMB2, ball and chain domain Macoilin PF09726.9 EDO14295.1 - 0.52 8.8 7.3 0.63 8.5 7.3 1.2 1 0 0 1 1 1 0 Macoilin family RAP1 PF07218.11 EDO14295.1 - 8.3 4.6 16.1 9.8 4.3 16.1 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) PS_Dcarbxylase PF02666.15 EDO14296.1 - 2.2e-66 223.2 0.0 2.8e-66 222.9 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase DUF5314 PF17241.2 EDO14300.1 - 4.1e-60 202.8 0.3 4.7e-60 202.6 0.3 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5314) DUF5314 PF17241.2 EDO14302.1 - 1.9e-56 190.8 0.2 2.2e-56 190.6 0.2 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5314) PTB PF08416.13 EDO14302.1 - 0.15 12.2 0.2 0.35 11.0 0.0 1.7 2 0 0 2 2 2 0 Phosphotyrosine-binding domain SF3a60_bindingd PF12108.8 EDO14303.1 - 0.027 14.4 0.1 0.097 12.6 0.0 2.1 2 0 0 2 2 2 0 Splicing factor SF3a60 binding domain DUF5314 PF17241.2 EDO14304.1 - 2.1e-81 272.3 0.4 2.9e-81 271.8 0.4 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF5314) Methyltransf_16 PF10294.9 EDO14306.1 - 1.1e-06 28.5 0.5 0.055 13.2 0.0 2.4 2 0 0 2 2 2 2 Lysine methyltransferase Semialdhyde_dhC PF02774.18 EDO14307.1 - 8.8e-44 149.8 0.0 1.2e-43 149.4 0.0 1.2 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, dimerisation domain Semialdhyde_dh PF01118.24 EDO14307.1 - 3.6e-29 101.6 0.0 6.1e-29 100.9 0.0 1.4 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain DXP_reductoisom PF02670.16 EDO14307.1 - 0.04 14.6 0.0 0.12 13.1 0.0 1.8 1 0 0 1 1 1 0 1-deoxy-D-xylulose 5-phosphate reductoisomerase DapB_N PF01113.20 EDO14307.1 - 0.054 13.6 0.0 0.15 12.2 0.0 1.8 1 1 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus RRM_1 PF00076.22 EDO14308.1 - 3.9e-19 68.2 0.2 1.2e-18 66.7 0.0 1.8 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EDO14308.1 - 0.0063 16.6 0.0 0.013 15.6 0.0 1.5 1 1 0 1 1 1 1 RNA recognition motif TFIIF_alpha PF05793.12 EDO14309.1 - 1.9 7.0 14.1 2.4 6.7 14.1 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Bromodomain PF00439.25 EDO14310.1 - 7.5e-28 96.4 5.7 8e-19 67.5 0.3 2.5 2 0 0 2 2 2 2 Bromodomain Urm1 PF09138.11 EDO14310.1 - 3.3 8.1 6.2 2.7 8.4 0.8 2.6 1 1 1 2 2 2 0 Urm1 (Ubiquitin related modifier) LAMTOR PF15454.6 EDO14311.1 - 3.6e-20 72.4 4.0 7.5e-20 71.3 4.0 1.6 1 0 0 1 1 1 1 Late endosomal/lysosomal adaptor and MAPK and MTOR activator Ribosomal_L50 PF10501.9 EDO14312.1 - 6e-22 77.9 0.6 1.3e-21 76.8 0.6 1.6 1 0 0 1 1 1 1 Ribosomal subunit 39S Glyco_transf_15 PF01793.16 EDO14313.1 - 1e-124 416.1 19.9 1.3e-124 415.7 19.9 1.2 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase Sulfotransfer_3 PF13469.6 EDO14313.1 - 0.081 13.3 0.1 0.16 12.3 0.1 1.6 1 0 0 1 1 1 0 Sulfotransferase family DUF502 PF04367.13 EDO14313.1 - 0.12 12.3 0.0 0.24 11.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF502) zf-CCCH_4 PF18044.1 EDO14314.1 - 2.2e-12 46.4 13.1 4.1e-06 26.5 3.1 2.4 2 0 0 2 2 2 2 CCCH-type zinc finger zf_CCCH_4 PF18345.1 EDO14314.1 - 8.9e-12 44.7 21.0 5.1e-06 26.3 6.2 2.4 2 0 0 2 2 2 2 Zinc finger domain zf-CCCH PF00642.24 EDO14314.1 - 5.1e-10 39.0 13.3 3.1e-05 23.7 4.0 2.4 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Torus PF16131.5 EDO14314.1 - 1.6e-07 32.0 6.7 0.0035 18.0 1.0 2.4 1 1 1 2 2 2 2 Torus domain zf-CCCH_3 PF15663.5 EDO14314.1 - 2.9e-05 24.3 2.3 3.6e-05 23.9 1.0 1.8 2 0 0 2 2 2 1 Zinc-finger containing family zf-CCCH_2 PF14608.6 EDO14314.1 - 0.02 15.4 20.9 0.043 14.3 6.9 2.8 2 1 0 2 2 2 0 RNA-binding, Nab2-type zinc finger Herpes_pp85 PF04637.12 EDO14314.1 - 1 7.7 11.3 1.6 7.0 11.3 1.2 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) RNA_pol_Rpb1_5 PF04998.17 EDO14315.1 - 1.6e-106 355.6 0.2 2.4e-106 355.0 0.2 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 EDO14315.1 - 7.2e-79 263.8 0.0 2.9e-78 261.8 0.0 2.1 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_6 PF04992.14 EDO14315.1 - 2.6e-64 216.6 0.5 5.7e-64 215.5 0.5 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 6 RNA_pol_Rpb1_7 PF04990.12 EDO14315.1 - 1.6e-47 160.9 3.1 4e-47 159.6 3.1 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 7 RNA_pol_Rpb1_3 PF04983.18 EDO14315.1 - 1.8e-47 161.2 0.0 4.7e-47 159.8 0.0 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.17 EDO14315.1 - 8.4e-36 122.2 0.1 2.6e-35 120.6 0.1 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_1 PF04997.12 EDO14315.1 - 2e-05 24.1 1.3 5e-05 22.8 1.3 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 DUF4123 PF13503.6 EDO14315.1 - 0.11 12.9 0.0 0.23 11.9 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4123) Filament_head PF04732.14 EDO14315.1 - 4.3 8.3 14.7 2.1e+02 2.9 16.6 2.6 2 0 0 2 2 2 0 Intermediate filament head (DNA binding) region DUF5314 PF17241.2 EDO14316.1 - 3e-80 268.5 0.4 3e-80 268.5 0.4 2.2 2 0 0 2 2 2 1 Family of unknown function (DUF5314) gag_pre-integrs PF13976.6 EDO14316.1 - 1.6e-14 53.5 0.3 4.3e-13 48.9 0.0 2.7 2 0 0 2 2 2 1 GAG-pre-integrase domain Stc1 PF12898.7 EDO14316.1 - 0.027 15.0 3.7 0.075 13.6 3.7 1.7 1 0 0 1 1 1 0 Stc1 domain eIF3g PF12353.8 EDO14316.1 - 0.065 13.6 5.5 0.23 11.9 4.5 2.2 1 1 1 2 2 2 0 Eukaryotic translation initiation factor 3 subunit G Ribosomal_S5 PF00333.20 EDO14317.1 - 1.4e-23 82.7 0.1 2.2e-23 82.0 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein S5, N-terminal domain Ribosomal_S5_C PF03719.15 EDO14317.1 - 1.8e-21 75.4 0.0 4.5e-21 74.1 0.0 1.7 2 0 0 2 2 2 1 Ribosomal protein S5, C-terminal domain Tctex-1 PF03645.13 EDO14318.1 - 2.3e-08 34.2 0.0 2.8e-08 33.9 0.0 1.1 1 0 0 1 1 1 1 Tctex-1 family DUF202 PF02656.15 EDO14319.1 - 6.1e-15 55.4 2.1 6.1e-15 55.4 2.1 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF202) DUF5337 PF17272.2 EDO14319.1 - 0.16 11.8 1.5 0.48 10.3 1.5 1.9 1 1 0 1 1 1 0 Family of unknown function (DUF5337) Y_phosphatase PF00102.27 EDO14320.1 - 4.1e-47 160.7 0.4 8e-47 159.8 0.4 1.5 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Rhodanese PF00581.20 EDO14320.1 - 6.2e-07 29.9 0.2 3e-06 27.7 0.0 2.3 3 0 0 3 3 3 1 Rhodanese-like domain Y_phosphatase3 PF13350.6 EDO14320.1 - 0.062 13.3 0.2 0.15 12.0 0.2 1.6 1 1 0 1 1 1 0 Tyrosine phosphatase family DSPc PF00782.20 EDO14320.1 - 0.2 11.5 0.1 0.2 11.5 0.1 2.7 3 0 0 3 3 3 0 Dual specificity phosphatase, catalytic domain DEAD PF00270.29 EDO14321.1 - 3.6e-49 166.9 0.0 1.3e-48 165.1 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDO14321.1 - 3.7e-15 56.2 0.0 2.2e-14 53.7 0.0 2.2 2 1 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDO14321.1 - 6.8e-05 22.9 0.0 0.00017 21.7 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 EDO14321.1 - 0.017 15.5 0.0 2.3 8.6 0.0 2.4 2 1 0 2 2 2 0 AAA domain DUF5335 PF17269.2 EDO14321.1 - 0.053 13.4 0.1 0.1 12.4 0.1 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5335) RNA_pol_L_2 PF13656.6 EDO14322.1 - 9.3e-35 118.3 0.0 1.4e-34 117.7 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.24 EDO14322.1 - 6.1e-16 57.6 0.0 9.5e-16 57.0 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Pkinase PF00069.25 EDO14323.1 - 2.5e-59 200.8 0.0 3.1e-59 200.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO14323.1 - 3.7e-30 105.1 0.0 4.9e-30 104.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDO14323.1 - 6.5e-06 25.7 0.0 1e-05 25.0 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 EDO14323.1 - 0.0025 17.8 0.0 0.0067 16.4 0.0 1.5 1 1 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 EDO14323.1 - 0.0039 16.6 0.0 0.0064 15.9 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 EDO14323.1 - 0.047 13.3 0.0 0.074 12.6 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase DUF4512 PF14975.6 EDO14324.1 - 7.4e-14 52.3 92.3 29 5.5 0.2 23.3 1 1 34 35 35 35 34 Domain of unknown function (DUF4512) ATP-synt_ab_Xtn PF16886.5 EDO14324.1 - 1.2e-06 28.4 75.2 5 7.0 0.2 19.6 1 1 33 34 34 34 33 ATPsynthase alpha/beta subunit N-term extension Nucleopor_Nup85 PF07575.13 EDO14326.1 - 1.1e-181 605.2 13.2 1.3e-181 605.0 13.2 1.0 1 0 0 1 1 1 1 Nup85 Nucleoporin Fer4_24 PF18109.1 EDO14326.1 - 0.14 12.4 0.8 1.1 9.6 0.2 2.5 2 0 0 2 2 2 0 Ferredoxin I 4Fe-4S cluster domain ATP-synt_C PF00137.21 EDO14327.1 - 5.5e-35 119.5 31.9 2.3e-22 79.1 13.6 2.1 2 0 0 2 2 2 2 ATP synthase subunit C zf-DNL PF05180.12 EDO14328.1 - 3.6e-31 106.9 2.7 7e-31 106.0 2.7 1.5 1 0 0 1 1 1 1 DNL zinc finger UPF0167 PF03691.14 EDO14328.1 - 0.033 14.0 0.1 0.041 13.7 0.1 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0167) Elf1 PF05129.13 EDO14328.1 - 0.037 14.1 1.4 0.062 13.4 1.4 1.3 1 0 0 1 1 1 0 Transcription elongation factor Elf1 like HypA PF01155.19 EDO14328.1 - 0.045 13.8 0.2 0.065 13.3 0.2 1.3 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Cyclase_polyket PF04673.12 EDO14328.1 - 0.13 12.5 0.0 0.2 11.9 0.0 1.3 1 0 0 1 1 1 0 Polyketide synthesis cyclase zinc_ribbon_4 PF13717.6 EDO14328.1 - 0.33 10.9 4.2 0.93 9.5 4.2 1.7 1 1 0 1 1 1 0 zinc-ribbon domain F-box-like PF12937.7 EDO14329.1 - 4.5e-07 29.7 0.6 4.5e-07 29.7 0.6 2.1 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 EDO14329.1 - 1.7e-06 27.7 1.9 1.7e-06 27.7 1.9 2.5 2 0 0 2 2 2 1 F-box domain Mei5_like PF17021.5 EDO14329.1 - 0.0056 16.7 0.3 0.073 13.1 0.0 2.8 2 0 0 2 2 2 1 Putative double-strand recombination repair-like F-box_4 PF15966.5 EDO14329.1 - 0.027 14.3 0.5 0.072 13.0 0.5 1.7 1 0 0 1 1 1 0 F-box tRNA_anti-codon PF01336.25 EDO14330.1 - 9.1e-13 48.0 0.2 1.6e-12 47.2 0.2 1.4 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain RPA_C PF08784.11 EDO14330.1 - 3.3e-07 30.9 0.0 1.3e-06 29.0 0.0 2.0 1 1 1 2 2 2 1 Replication protein A C terminal HTH_IclR PF09339.10 EDO14330.1 - 0.036 13.9 0.0 0.063 13.1 0.0 1.4 1 0 0 1 1 1 0 IclR helix-turn-helix domain CDC24_OB3 PF17244.2 EDO14330.1 - 0.041 13.6 0.3 0.072 12.8 0.1 1.5 2 0 0 2 2 2 0 Cell division control protein 24, OB domain 3 HTH_24 PF13412.6 EDO14330.1 - 0.057 13.0 0.0 0.15 11.7 0.0 1.7 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding DUF5611 PF18446.1 EDO14333.1 - 0.18 12.7 4.6 0.34 11.8 1.2 2.7 1 1 1 2 2 2 0 Domain of unknown function (DUF5611) DUF1482 PF07358.11 EDO14334.1 - 0.12 12.3 0.0 0.29 11.1 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1482) DUF4512 PF14975.6 EDO14335.1 - 1.8e-12 47.9 105.4 34 5.3 0.2 25.2 2 2 36 38 38 38 36 Domain of unknown function (DUF4512) ATP-synt_ab_Xtn PF16886.5 EDO14335.1 - 1.6e-05 24.7 84.5 36 4.2 0.2 21.7 2 2 35 38 38 38 32 ATPsynthase alpha/beta subunit N-term extension TPR_1 PF00515.28 EDO14337.1 - 8.8e-50 164.6 22.4 8.5e-08 31.7 0.0 11.1 11 1 0 11 11 11 8 Tetratricopeptide repeat TPR_2 PF07719.17 EDO14337.1 - 1e-45 150.2 24.8 4.6e-05 23.2 0.0 10.5 11 0 0 11 11 10 8 Tetratricopeptide repeat TPR_17 PF13431.6 EDO14337.1 - 1.3e-31 106.7 27.3 2.3e-05 24.5 0.1 10.8 11 2 0 11 11 10 8 Tetratricopeptide repeat TPR_8 PF13181.6 EDO14337.1 - 4.4e-29 98.2 17.9 0.032 14.4 0.0 11.0 10 1 0 10 10 10 7 Tetratricopeptide repeat TPR_16 PF13432.6 EDO14337.1 - 5.5e-24 84.5 13.2 0.00011 22.7 1.6 6.4 4 2 3 7 7 7 5 Tetratricopeptide repeat TPR_14 PF13428.6 EDO14337.1 - 2.7e-23 80.7 21.6 0.00083 20.0 0.1 9.8 4 3 6 10 10 10 6 Tetratricopeptide repeat TPR_11 PF13414.6 EDO14337.1 - 4.6e-22 77.4 27.3 0.00046 19.8 1.2 10.3 4 3 6 10 10 10 6 TPR repeat TPR_12 PF13424.6 EDO14337.1 - 1.1e-21 76.9 34.5 0.00012 22.3 0.5 8.8 4 2 4 8 8 8 7 Tetratricopeptide repeat TPR_7 PF13176.6 EDO14337.1 - 2.1e-19 68.0 27.9 9.4e-05 22.2 0.1 9.8 11 0 0 11 11 10 4 Tetratricopeptide repeat TPR_9 PF13371.6 EDO14337.1 - 5.2e-18 65.0 15.7 2.8e-05 24.2 0.1 6.5 2 2 6 8 8 8 6 Tetratricopeptide repeat TPR_19 PF14559.6 EDO14337.1 - 2.3e-17 63.2 18.6 2.9e-05 24.5 0.4 7.3 2 1 6 8 8 8 4 Tetratricopeptide repeat TPR_6 PF13174.6 EDO14337.1 - 2.7e-13 49.6 27.7 0.21 12.3 0.0 9.5 9 1 0 9 9 9 3 Tetratricopeptide repeat ANAPC3 PF12895.7 EDO14337.1 - 3.5e-11 43.2 12.0 0.00043 20.5 3.4 4.0 4 1 0 4 4 4 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_15 PF13429.6 EDO14337.1 - 8.1e-08 31.8 17.2 0.0033 16.7 0.3 4.8 1 1 3 4 4 4 4 Tetratricopeptide repeat TPR_10 PF13374.6 EDO14337.1 - 4.2e-06 26.4 29.4 0.025 14.4 0.5 8.7 10 0 0 10 10 9 3 Tetratricopeptide repeat RPN7 PF10602.9 EDO14337.1 - 0.00041 20.1 4.5 1.1 9.0 0.1 4.7 2 2 3 5 5 5 2 26S proteasome subunit RPN7 ChAPs PF09295.10 EDO14337.1 - 0.0019 17.3 3.6 0.11 11.4 0.8 3.2 2 1 0 3 3 3 1 ChAPs (Chs5p-Arf1p-binding proteins) SNAP PF14938.6 EDO14337.1 - 0.0043 16.5 18.5 0.93 8.9 5.8 4.8 4 2 1 5 5 5 2 Soluble NSF attachment protein, SNAP TPR_21 PF09976.9 EDO14337.1 - 0.074 12.7 19.1 0.3 10.8 0.0 4.1 4 2 0 4 4 4 0 Tetratricopeptide repeat-like domain MIT PF04212.18 EDO14337.1 - 0.09 12.9 13.2 25 5.0 0.1 6.3 6 1 0 6 6 6 0 MIT (microtubule interacting and transport) domain Mod_r PF07200.13 EDO14337.1 - 0.096 12.8 0.1 0.096 12.8 0.1 3.2 2 1 1 3 3 3 0 Modifier of rudimentary (Mod(r)) protein NARP1 PF12569.8 EDO14337.1 - 0.11 11.4 12.0 1.2 7.9 0.0 4.5 3 2 1 5 5 5 0 NMDA receptor-regulated protein 1 DUF1644 PF07800.12 EDO14337.1 - 0.23 11.5 0.9 25 4.9 0.0 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF1644) Pex14_N PF04695.13 EDO14337.1 - 1.1 9.9 10.6 3 8.5 9.3 2.1 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region TPR_20 PF14561.6 EDO14337.1 - 1.6 9.1 0.0 1.6 9.1 0.0 4.4 4 1 1 5 5 4 0 Tetratricopeptide repeat Mad3_BUB1_I PF08311.12 EDO14337.1 - 3.4 7.7 11.9 19 5.3 0.0 5.3 4 2 1 5 5 5 0 Mad3/BUB1 homology region 1 ABC_membrane PF00664.23 EDO14338.1 - 8.4e-41 140.4 59.4 1.6e-25 90.3 17.8 4.4 4 1 0 4 4 4 2 ABC transporter transmembrane region ABC_tran PF00005.27 EDO14338.1 - 2e-22 80.2 0.8 4.5e-19 69.3 0.0 2.5 2 0 0 2 2 2 2 ABC transporter AAA_23 PF13476.6 EDO14338.1 - 0.0051 17.3 0.2 0.017 15.7 0.2 1.9 1 0 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 EDO14338.1 - 0.0053 16.7 0.0 0.014 15.3 0.0 1.7 1 0 0 1 1 1 1 RsgA GTPase T2SSE PF00437.20 EDO14338.1 - 0.044 12.9 0.3 0.096 11.7 0.0 1.6 2 0 0 2 2 2 0 Type II/IV secretion system protein RRM_1 PF00076.22 EDO14339.1 - 1.4e-18 66.5 5.2 7.1e-10 38.6 0.5 3.4 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EDO14339.1 - 3.9e-05 23.7 0.3 0.0025 17.9 0.1 2.3 2 0 0 2 2 2 1 RNA recognition motif RRM_Rrp7 PF17799.1 EDO14339.1 - 0.0032 17.3 0.1 0.69 9.7 0.0 2.7 2 1 1 3 3 3 2 Rrp7 RRM-like N-terminal domain HTH_Crp_2 PF13545.6 EDO14339.1 - 0.065 13.2 0.0 0.12 12.4 0.0 1.4 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain DUF1033 PF06279.11 EDO14342.1 - 0.007 16.5 0.3 0.034 14.3 0.3 2.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1033) dUTPase PF00692.19 EDO14343.1 - 3.1e-45 153.0 0.0 3.6e-45 152.8 0.0 1.0 1 0 0 1 1 1 1 dUTPase Sedlin_N PF04628.13 EDO14344.1 - 3.3e-50 169.6 0.0 4e-50 169.3 0.0 1.1 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region Sybindin PF04099.12 EDO14344.1 - 4.2e-08 33.2 0.1 6.8e-08 32.5 0.1 1.3 1 0 0 1 1 1 1 Sybindin-like family Opy2 PF09463.10 EDO14347.1 - 7e-10 39.0 19.8 1e-09 38.5 19.8 1.3 1 0 0 1 1 1 1 Opy2 protein S1FA PF04689.13 EDO14347.1 - 0.086 13.0 0.0 0.14 12.3 0.0 1.3 1 0 0 1 1 1 0 DNA binding protein S1FA Sec16_N PF12935.7 EDO14347.1 - 0.32 11.1 6.7 3.8 7.6 3.6 2.3 2 0 0 2 2 2 0 Vesicle coat trafficking protein Sec16 N-terminus tRNA-synt_1b PF00579.25 EDO14348.1 - 6.4e-55 186.5 0.0 8.6e-55 186.1 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) TyrRSs_C PF16714.5 EDO14348.1 - 0.00058 19.7 0.3 0.08 12.7 0.3 2.9 2 1 0 2 2 2 1 Tyrosyl-tRNA synthetase C-terminal domain PIG-Y PF15159.6 EDO14349.1 - 0.14 13.1 9.4 0.2 12.6 9.4 1.2 1 0 0 1 1 1 0 Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y Transglut_core PF01841.19 EDO14350.1 - 2.5e-11 44.0 0.0 5.5e-11 42.9 0.0 1.6 1 0 0 1 1 1 1 Transglutaminase-like superfamily Rad4 PF03835.15 EDO14350.1 - 1.3e-09 37.9 5.3 1.1e-08 34.9 5.3 2.3 1 1 0 1 1 1 1 Rad4 transglutaminase-like domain Desulfoferrod_N PF06397.12 EDO14350.1 - 0.0053 16.3 0.9 0.0053 16.3 0.9 1.9 2 0 0 2 2 2 1 Desulfoferrodoxin, N-terminal domain PAW PF04721.17 EDO14350.1 - 0.048 13.4 1.3 0.099 12.4 1.3 1.6 1 0 0 1 1 1 0 PNGase C-terminal domain, mannose-binding module PAW Zn-ribbon_8 PF09723.10 EDO14350.1 - 0.083 13.0 1.2 15 5.8 0.2 2.8 2 0 0 2 2 2 0 Zinc ribbon domain Zn_Tnp_IS1595 PF12760.7 EDO14350.1 - 0.11 12.5 2.9 0.61 10.1 2.9 2.2 1 1 0 1 1 1 0 Transposase zinc-ribbon domain TrbM PF07424.11 EDO14350.1 - 0.22 11.4 2.7 1.2 9.0 0.2 3.0 2 2 2 4 4 4 0 TrbM DUF1972 PF09314.11 EDO14351.1 - 0.084 12.4 0.2 1.9 8.0 0.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1972) Dynamin_N PF00350.23 EDO14352.1 - 2e-07 31.2 0.2 1.2e-06 28.7 0.0 2.2 2 1 0 2 2 2 1 Dynamin family MMR_HSR1 PF01926.23 EDO14352.1 - 0.0063 16.6 0.0 0.017 15.2 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase PPV_E1_C PF00519.17 EDO14352.1 - 0.033 13.0 0.6 0.17 10.7 0.0 1.9 2 0 0 2 2 2 0 Papillomavirus helicase Glucan_synthase PF02364.15 EDO14354.1 - 2e-145 486.1 7.0 2.5e-145 485.8 7.0 1.1 1 0 0 1 1 1 1 1,3-beta-glucan synthase component TMEM171 PF15471.6 EDO14354.1 - 0.0039 16.2 1.8 0.0065 15.5 1.8 1.3 1 0 0 1 1 1 1 Transmembrane protein family 171 UxuA PF03786.13 EDO14354.1 - 0.08 11.8 0.0 0.12 11.2 0.0 1.2 1 0 0 1 1 1 0 D-mannonate dehydratase (UxuA) Glyco_hydro_72 PF03198.14 EDO14355.1 - 3.6e-137 456.8 1.9 4.8e-137 456.4 1.9 1.1 1 0 0 1 1 1 1 Glucanosyltransferase X8 PF07983.13 EDO14355.1 - 4.9e-17 62.4 1.6 1.2e-16 61.1 1.6 1.7 1 0 0 1 1 1 1 X8 domain Pkinase PF00069.25 EDO14356.1 - 2.6e-73 246.6 0.0 4.5e-73 245.9 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO14356.1 - 1.8e-30 106.1 0.0 9.1e-29 100.5 0.0 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDO14356.1 - 6.7e-08 32.2 0.3 1.5e-05 24.4 0.0 2.6 3 0 0 3 3 3 2 Kinase-like APH PF01636.23 EDO14356.1 - 0.053 13.4 0.0 5.2 6.9 0.0 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.14 EDO14356.1 - 0.066 12.6 0.0 0.12 11.7 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family MutS_V PF00488.21 EDO14357.1 - 1.9e-62 210.6 0.1 1.7e-61 207.6 0.0 2.5 2 0 0 2 2 2 1 MutS domain V MutS_III PF05192.18 EDO14357.1 - 5.7e-33 114.7 2.5 2.7e-32 112.6 0.3 2.6 2 0 0 2 2 2 1 MutS domain III MutS_I PF01624.20 EDO14357.1 - 6.6e-30 103.6 0.1 1.4e-29 102.6 0.1 1.6 1 0 0 1 1 1 1 MutS domain I MutS_IV PF05190.18 EDO14357.1 - 1.1e-06 28.8 1.1 5.6e-06 26.6 1.1 2.3 1 0 0 1 1 1 1 MutS family domain IV MutS_II PF05188.17 EDO14357.1 - 1.6e-05 25.2 1.9 3.9e-05 23.9 0.3 2.6 2 1 1 3 3 3 1 MutS domain II DUF1322 PF07032.11 EDO14357.1 - 2.6 8.6 8.1 0.2 12.2 0.6 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF1322) AMPK1_CBM PF16561.5 EDO14358.1 - 4.5e-29 100.5 0.2 2.7e-28 98.0 0.0 2.4 2 0 0 2 2 2 1 Glycogen recognition site of AMP-activated protein kinase AMPKBI PF04739.15 EDO14358.1 - 1.3e-28 99.0 2.6 1.3e-28 99.0 2.6 3.1 3 1 0 3 3 3 1 5'-AMP-activated protein kinase beta subunit, interaction domain Spt20 PF12090.8 EDO14358.1 - 1.1 8.9 44.6 0.38 10.3 19.2 2.7 3 0 0 3 3 3 0 Spt20 family pRN1_helical PF13010.6 EDO14359.1 - 0.86 9.6 5.2 2.8 7.9 2.9 2.6 1 1 1 2 2 2 0 Primase helical domain SKN1 PF03935.15 EDO14360.1 - 9.4e-252 835.8 7.1 1.2e-251 835.4 7.1 1.1 1 0 0 1 1 1 1 Beta-glucan synthesis-associated protein (SKN1) SBF_like PF13593.6 EDO14361.1 - 3.6e-118 394.4 17.5 4.3e-118 394.2 17.5 1.1 1 0 0 1 1 1 1 SBF-like CPA transporter family (DUF4137) SBF PF01758.16 EDO14361.1 - 5e-12 45.9 9.5 9.5e-12 45.0 9.5 1.4 1 0 0 1 1 1 1 Sodium Bile acid symporter family DUF4491 PF14898.6 EDO14361.1 - 7.7 7.0 9.4 0.47 10.9 3.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4491) Actin PF00022.19 EDO14362.1 - 1.1e-19 70.4 0.0 1.6e-17 63.2 0.0 2.8 1 1 0 1 1 1 1 Actin FtsA PF14450.6 EDO14362.1 - 0.054 13.9 1.3 0.094 13.1 1.3 1.4 1 1 0 1 1 1 0 Cell division protein FtsA Histone PF00125.24 EDO14363.1 - 1.2e-36 125.9 3.7 1.2e-36 125.9 3.7 1.6 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 EDO14363.1 - 0.0086 16.2 0.1 0.019 15.1 0.1 1.5 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 EDO14363.1 - 0.02 15.3 0.1 0.039 14.3 0.1 1.5 1 0 0 1 1 1 0 CENP-S protein PI3_PI4_kinase PF00454.27 EDO14364.1 - 0.04 13.7 0.0 0.053 13.3 0.0 1.4 1 1 0 1 1 1 0 Phosphatidylinositol 3- and 4-kinase MFS_1 PF07690.16 EDO14365.1 - 4.3e-19 68.7 24.5 6.1e-19 68.2 24.5 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF3980 PF13140.6 EDO14365.1 - 0.21 12.0 0.1 0.21 12.0 0.1 2.9 4 0 0 4 4 4 0 Domain of unknown function (DUF3980) SecY PF00344.20 EDO14366.1 - 5e-63 213.2 10.4 6.6e-63 212.8 10.4 1.1 1 0 0 1 1 1 1 SecY translocase Plug_translocon PF10559.9 EDO14366.1 - 4.2e-17 61.7 1.8 8.3e-17 60.7 0.2 2.6 2 0 0 2 2 2 1 Plug domain of Sec61p Claudin_3 PF06653.11 EDO14366.1 - 0.22 11.5 4.2 1.2 9.0 0.0 2.8 3 0 0 3 3 3 0 Tight junction protein, Claudin-like SdpI PF13630.6 EDO14366.1 - 4.8 7.4 6.5 0.38 10.9 0.1 2.5 3 0 0 3 3 3 0 SdpI/YhfL protein family FlxA PF14282.6 EDO14367.1 - 2.5 8.1 6.5 0.34 10.9 0.7 2.5 3 0 0 3 3 3 0 FlxA-like protein NOC3p PF07540.11 EDO14368.1 - 1.5e-28 99.1 0.3 1.5e-28 99.1 0.3 3.2 3 1 0 3 3 3 1 Nucleolar complex-associated protein CBF PF03914.17 EDO14368.1 - 3.3e-23 82.6 0.1 3.3e-23 82.6 0.1 2.5 2 1 0 2 2 2 1 CBF/Mak21 family NARP1 PF12569.8 EDO14368.1 - 0.047 12.6 23.8 0.21 10.5 5.3 2.7 3 0 0 3 3 3 0 NMDA receptor-regulated protein 1 CDC45 PF02724.14 EDO14368.1 - 0.071 11.4 14.2 0.03 12.6 8.2 2.1 2 0 0 2 2 2 0 CDC45-like protein Peptidase_S64 PF08192.11 EDO14368.1 - 0.51 8.8 9.3 0.15 10.6 2.3 2.2 2 0 0 2 2 2 0 Peptidase family S64 AAA_11 PF13086.6 EDO14368.1 - 0.78 9.5 15.5 3 7.6 1.3 2.3 2 0 0 2 2 2 0 AAA domain Gti1_Pac2 PF09729.9 EDO14368.1 - 4.2 7.4 11.7 1.7 8.7 5.8 2.3 2 0 0 2 2 2 0 Gti1/Pac2 family DUF2052 PF09747.9 EDO14368.1 - 5.2 7.1 23.8 7.3 6.7 15.3 2.4 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) DNA_pol_phi PF04931.13 EDO14368.1 - 5.6 4.9 30.9 1.4 6.9 1.6 2.6 3 0 0 3 3 3 0 DNA polymerase phi FAM60A PF15396.6 EDO14368.1 - 9.3 6.2 10.6 11 6.0 4.4 2.4 2 0 0 2 2 2 0 Protein Family FAM60A RVT_2 PF07727.14 EDO14370.1 - 3e-90 302.1 0.0 4.3e-90 301.6 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 EDO14370.1 - 9.3e-21 74.2 0.1 2.4e-20 72.9 0.1 1.7 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 EDO14370.1 - 0.0089 15.8 0.0 0.035 13.9 0.0 2.0 2 0 0 2 2 2 1 Integrase core domain DUF5314 PF17241.2 EDO14371.1 - 1.2e-42 145.8 0.8 1.4e-42 145.6 0.8 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5314) KH_dom-like PF14714.6 EDO14371.1 - 0.095 13.0 0.0 0.15 12.4 0.0 1.3 1 0 0 1 1 1 0 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal PTB PF08416.13 EDO14371.1 - 0.1 12.7 0.1 0.27 11.4 0.0 1.8 2 0 0 2 2 2 0 Phosphotyrosine-binding domain PVL_ORF50 PF07768.11 EDO14372.1 - 1.2 9.4 31.3 14 6.0 0.3 7.9 1 1 10 11 11 11 0 PVL ORF-50-like family MetallophosN PF16371.5 EDO14372.1 - 4.8 7.5 14.0 68 3.8 0.4 5.5 1 1 6 7 7 7 0 N terminal of Calcineurin-like phosphoesterase DUF4512 PF14975.6 EDO14373.1 - 1.5e-12 48.1 150.6 36 5.2 0.8 33.8 1 1 52 53 53 53 48 Domain of unknown function (DUF4512) ATP-synt_ab_Xtn PF16886.5 EDO14373.1 - 4.9e-05 23.2 117.6 7.2 6.5 0.2 28.3 1 1 52 53 53 53 2 ATPsynthase alpha/beta subunit N-term extension DUF1214 PF06742.11 EDO14377.1 - 1.5e-61 205.6 100.9 21 5.6 0.0 52.3 42 8 12 54 54 54 47 Protein of unknown function (DUF1214) Ribosomal_L23 PF00276.20 EDO14379.1 - 1.4e-09 38.2 0.0 2.6e-09 37.3 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L23 RNA_pol_Rpb2_6 PF00562.28 EDO14380.1 - 7.8e-127 423.6 0.1 1.4e-126 422.7 0.1 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 EDO14380.1 - 7.3e-74 247.7 0.1 1.3e-73 246.9 0.1 1.4 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_2 PF04561.14 EDO14380.1 - 7e-52 175.8 0.0 1.4e-51 174.9 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_7 PF04560.20 EDO14380.1 - 1.3e-33 115.3 0.1 3e-33 114.1 0.1 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_4 PF04566.13 EDO14380.1 - 8.8e-26 90.0 0.3 2e-25 88.8 0.3 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_3 PF04565.16 EDO14380.1 - 2e-24 85.5 0.1 6.4e-24 83.9 0.1 2.0 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_5 PF04567.17 EDO14380.1 - 1.2e-19 70.5 4.3 1.2e-19 70.5 4.3 2.1 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 5 S1 PF00575.23 EDO14381.1 - 4.8e-18 65.3 0.1 6.8e-18 64.8 0.1 1.2 1 0 0 1 1 1 1 S1 RNA binding domain SHS2_Rpb7-N PF03876.17 EDO14381.1 - 3.5e-17 62.5 0.0 7.2e-17 61.5 0.0 1.5 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 RNA_pol_Rbc25 PF08292.12 EDO14381.1 - 1.3e-05 25.5 0.0 2.4e-05 24.6 0.0 1.4 1 1 0 1 1 1 1 RNA polymerase III subunit Rpc25 CALCOCO1 PF07888.11 EDO14384.1 - 0.015 14.2 2.4 0.019 13.9 2.4 1.1 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like IIGP PF05049.13 EDO14384.1 - 0.02 14.0 0.2 0.024 13.7 0.2 1.2 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) KxDL PF10241.9 EDO14384.1 - 0.049 13.9 0.5 0.38 11.1 0.2 2.4 2 0 0 2 2 2 0 Uncharacterized conserved protein APG6_N PF17675.1 EDO14384.1 - 0.051 14.1 7.3 0.35 11.4 6.6 2.4 2 1 0 2 2 2 0 Apg6 coiled-coil region ST7 PF04184.12 EDO14384.1 - 0.088 11.3 0.7 0.12 10.8 0.7 1.1 1 0 0 1 1 1 0 ST7 protein Sipho_Gp157 PF05565.11 EDO14384.1 - 0.31 11.0 6.5 0.55 10.2 5.0 2.2 2 1 0 2 2 2 0 Siphovirus Gp157 zf-C3HC4_3 PF13920.6 EDO14385.1 - 1.7e-07 31.0 14.0 3.1e-07 30.2 14.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EDO14385.1 - 2.4 8.1 12.0 4.3 7.3 12.0 1.4 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 AICARFT_IMPCHas PF01808.18 EDO14386.1 - 2.3e-90 303.0 0.0 3.6e-90 302.4 0.0 1.3 1 0 0 1 1 1 1 AICARFT/IMPCHase bienzyme MGS PF02142.22 EDO14386.1 - 1.4e-25 89.3 0.0 2.8e-25 88.3 0.0 1.5 1 0 0 1 1 1 1 MGS-like domain RRM_1 PF00076.22 EDO14387.1 - 1.8e-32 111.0 0.0 2.1e-15 56.3 0.1 4.5 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EDO14387.1 - 2.2e-05 24.5 0.0 0.0006 19.9 0.0 2.9 3 0 0 3 3 3 1 RNA recognition motif DUF4872 PF16169.5 EDO14387.1 - 0.083 12.6 0.0 0.16 11.7 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4872) MFMR_assoc PF16596.5 EDO14387.1 - 0.52 10.8 6.3 1.5 9.3 6.3 1.8 1 0 0 1 1 1 0 Disordered region downstream of MFMR Zip PF02535.22 EDO14387.1 - 1.8 7.7 3.9 0.78 8.9 1.5 1.7 2 0 0 2 2 2 0 ZIP Zinc transporter Caleosin PF05042.13 EDO14387.1 - 5 7.0 10.4 5.5 6.9 3.1 2.9 1 1 2 3 3 3 0 Caleosin related protein FLILHELTA PF10306.9 EDO14388.1 - 2.2e-21 76.0 0.1 1.3e-20 73.5 0.1 2.0 1 1 1 2 2 2 1 Hypothetical protein FLILHELTA ApbA_C PF08546.11 EDO14389.1 - 3e-07 30.7 0.1 5.3e-06 26.7 0.0 2.3 2 0 0 2 2 2 1 Ketopantoate reductase PanE/ApbA C terminal Macoilin PF09726.9 EDO14390.1 - 5.9 5.3 13.1 8.2 4.8 13.1 1.1 1 0 0 1 1 1 0 Macoilin family DJ-1_PfpI PF01965.24 EDO14391.1 - 4.3e-07 29.9 0.0 2.3e-06 27.5 0.0 2.1 1 1 0 1 1 1 1 DJ-1/PfpI family ThiJ_like PF17124.5 EDO14391.1 - 0.00013 21.7 0.1 0.00084 19.1 0.1 1.9 2 0 0 2 2 2 1 ThiJ/PfpI family-like KAR9 PF08580.10 EDO14393.1 - 8.8e-48 163.4 25.1 1.3e-47 162.9 25.1 1.1 1 0 0 1 1 1 1 Yeast cortical protein KAR9 DUF4047 PF13256.6 EDO14393.1 - 0.24 11.6 0.1 0.24 11.6 0.1 2.6 2 1 1 3 3 3 0 Domain of unknown function (DUF4047) Tropomyosin_1 PF12718.7 EDO14393.1 - 0.52 10.5 14.3 0.73 10.0 1.2 3.1 3 0 0 3 3 3 0 Tropomyosin like Wtap PF17098.5 EDO14393.1 - 0.53 10.2 7.1 0.07 13.1 1.6 2.4 3 1 0 3 3 3 0 WTAP/Mum2p family CDC45 PF02724.14 EDO14395.1 - 1.5 7.1 11.2 2.1 6.6 11.2 1.1 1 0 0 1 1 1 0 CDC45-like protein Nop14 PF04147.12 EDO14395.1 - 2.8 6.0 15.9 4.6 5.3 15.9 1.2 1 0 0 1 1 1 0 Nop14-like family Tim54 PF11711.8 EDO14395.1 - 9.4 4.9 8.0 14 4.3 8.0 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DEAD_2 PF06733.15 EDO14396.1 - 2.6e-52 177.0 1.0 4.9e-52 176.1 1.0 1.5 1 0 0 1 1 1 1 DEAD_2 Helicase_C_2 PF13307.6 EDO14396.1 - 5.7e-48 163.3 0.0 1.9e-47 161.6 0.0 1.9 1 0 0 1 1 1 1 Helicase C-terminal domain DEAD PF00270.29 EDO14396.1 - 0.0011 18.8 1.1 0.33 10.7 0.1 2.8 2 1 0 2 2 2 2 DEAD/DEAH box helicase AAA_22 PF13401.6 EDO14396.1 - 0.022 15.0 1.1 1.9 8.8 0.0 2.8 2 0 0 2 2 2 0 AAA domain PhoH PF02562.16 EDO14396.1 - 0.023 14.1 0.2 1.9 7.9 0.0 2.5 2 0 0 2 2 2 0 PhoH-like protein ResIII PF04851.15 EDO14396.1 - 0.038 14.0 13.1 0.4 10.7 0.0 3.8 3 1 1 4 4 4 0 Type III restriction enzyme, res subunit NPC1_N PF16414.5 EDO14397.1 - 5.1e-58 196.5 4.8 5.7e-58 196.3 4.8 1.0 1 0 0 1 1 1 1 Niemann-Pick C1 N terminus Folate_rec PF03024.14 EDO14397.1 - 0.00011 22.2 1.1 0.00014 21.7 1.1 1.2 1 0 0 1 1 1 1 Folate receptor family CxC5 PF18718.1 EDO14397.1 - 0.021 14.9 0.2 0.034 14.2 0.2 1.4 1 1 0 1 1 1 0 CxC5 like cysteine cluster associated with KDZ transposases zinc_ribbon_5 PF13719.6 EDO14397.1 - 0.16 11.8 2.1 0.16 11.8 0.1 2.1 2 0 0 2 2 2 0 zinc-ribbon domain Rhodanese PF00581.20 EDO14398.1 - 4.6e-11 43.2 0.1 1e-10 42.0 0.1 1.6 1 0 0 1 1 1 1 Rhodanese-like domain Pkinase PF00069.25 EDO14399.1 - 4e-40 137.9 0.2 6.5e-32 110.9 0.0 2.4 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EDO14399.1 - 1.3e-24 86.9 0.0 4.4e-16 58.9 0.0 2.7 1 1 1 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 EDO14399.1 - 9.4e-05 21.9 0.0 0.00062 19.2 0.0 2.2 2 1 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 EDO14399.1 - 0.0021 16.9 0.2 0.007 15.2 0.0 1.8 2 0 0 2 2 2 1 Fungal protein kinase Polbeta PF18765.1 EDO14399.1 - 0.084 13.0 0.7 1.4 9.0 0.3 2.8 2 0 0 2 2 2 0 Polymerase beta, Nucleotidyltransferase zf-C2H2 PF00096.26 EDO14400.1 - 9.1e-13 47.9 12.0 1.7e-06 28.2 2.9 3.0 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EDO14400.1 - 6.9e-09 35.8 11.6 0.0003 21.4 1.7 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EDO14400.1 - 4.6e-07 30.0 18.2 3.4e-06 27.2 3.1 3.4 3 0 0 3 3 3 2 Zinc-finger double domain zf-BED PF02892.15 EDO14400.1 - 1.7e-06 27.9 4.8 0.0018 18.3 0.9 3.1 2 0 0 2 2 2 2 BED zinc finger zf-C2H2_jaz PF12171.8 EDO14400.1 - 5.2e-06 26.6 11.8 0.023 15.0 5.3 3.1 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-C2HE PF16278.5 EDO14400.1 - 0.00032 21.1 10.5 0.11 12.9 0.9 3.3 2 1 1 3 3 3 2 C2HE / C2H2 / C2HC zinc-binding finger PyrI_C PF02748.15 EDO14400.1 - 0.016 15.1 4.3 0.11 12.4 0.6 2.9 1 1 1 2 2 2 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain GAGA PF09237.11 EDO14400.1 - 0.042 13.7 1.9 0.87 9.4 1.1 2.7 1 1 1 2 2 2 0 GAGA factor zf-met PF12874.7 EDO14400.1 - 0.06 13.8 7.1 6.1 7.4 0.1 3.1 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-Di19 PF05605.12 EDO14400.1 - 0.078 13.3 4.0 0.15 12.4 4.0 1.5 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-AN1 PF01428.16 EDO14400.1 - 0.11 12.7 2.1 9.7 6.4 0.2 2.4 2 0 0 2 2 2 0 AN1-like Zinc finger zf_C2H2_ZHX PF18387.1 EDO14400.1 - 0.12 12.0 4.9 0.7 9.6 3.2 2.5 1 1 1 2 2 2 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-C2H2_6 PF13912.6 EDO14400.1 - 0.14 12.2 14.0 0.028 14.4 5.1 2.4 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_2 PF12756.7 EDO14400.1 - 0.15 12.4 9.7 1.7 9.0 1.8 3.6 2 1 1 3 3 3 0 C2H2 type zinc-finger (2 copies) zf-LYAR PF08790.11 EDO14400.1 - 0.3 11.0 3.9 0.87 9.5 0.2 2.5 2 0 0 2 2 2 0 LYAR-type C2HC zinc finger zf-C2H2_11 PF16622.5 EDO14400.1 - 1.5 8.6 4.5 3.6 7.4 0.3 2.5 2 0 0 2 2 2 0 zinc-finger C2H2-type RVT_2 PF07727.14 EDO14401.1 - 2.4e-90 302.4 0.0 3.2e-90 302.0 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF5314 PF17241.2 EDO14402.1 - 6.4e-80 267.4 0.4 6.4e-80 267.4 0.4 2.1 2 0 0 2 2 2 1 Family of unknown function (DUF5314) rve PF00665.26 EDO14402.1 - 1e-20 74.1 0.1 2.1e-20 73.1 0.1 1.6 1 0 0 1 1 1 1 Integrase core domain gag_pre-integrs PF13976.6 EDO14402.1 - 5.2e-14 51.9 0.3 1e-12 47.7 0.0 2.7 2 0 0 2 2 2 1 GAG-pre-integrase domain rve_3 PF13683.6 EDO14402.1 - 0.011 15.5 0.0 0.032 14.0 0.0 1.8 1 0 0 1 1 1 0 Integrase core domain Stc1 PF12898.7 EDO14402.1 - 0.23 12.0 3.3 0.89 10.2 3.3 2.0 1 0 0 1 1 1 0 Stc1 domain Ribonuc_2-5A PF06479.12 EDO14403.1 - 1.8e-42 144.5 1.2 1.8e-42 144.5 1.2 2.4 2 0 0 2 2 2 1 Ribonuclease 2-5A Pkinase PF00069.25 EDO14403.1 - 3.1e-41 141.5 0.0 1.4e-29 103.2 0.0 2.5 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EDO14403.1 - 4.6e-22 78.6 0.0 1.3e-20 73.8 0.0 2.5 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EDO14403.1 - 0.0011 18.3 0.2 0.0011 18.3 0.2 1.7 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family SR-25 PF10500.9 EDO14403.1 - 0.0055 16.4 6.5 0.0055 16.4 6.5 2.4 2 0 0 2 2 2 1 Nuclear RNA-splicing-associated protein PQQ PF01011.21 EDO14403.1 - 0.018 14.9 0.4 0.62 10.1 0.1 3.1 3 0 0 3 3 3 0 PQQ enzyme repeat SpoIIE PF07228.12 EDO14404.1 - 1.2e-27 97.1 0.0 1.5e-27 96.8 0.0 1.1 1 0 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) PP2C PF00481.21 EDO14404.1 - 6.1e-08 32.6 0.1 0.0087 15.7 0.1 2.1 2 0 0 2 2 2 2 Protein phosphatase 2C Exo_endo_phos PF03372.23 EDO14405.1 - 4.4e-27 95.1 0.0 5.8e-27 94.7 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Ribosomal_L30 PF00327.20 EDO14406.1 - 3e-14 52.7 0.2 4e-14 52.2 0.2 1.2 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e RNB PF00773.19 EDO14408.1 - 7.9e-64 216.0 3.9 7.9e-64 216.0 3.9 2.0 2 1 0 2 2 2 1 RNB domain Rhamnogal_lyase PF06045.11 EDO14408.1 - 0.14 11.6 2.9 3.4 7.0 0.4 2.7 2 1 1 3 3 3 0 Rhamnogalacturonate lyase family Pept_tRNA_hydro PF01195.19 EDO14409.1 - 1.3e-34 119.6 0.1 1.6e-34 119.4 0.1 1.0 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase gag_pre-integrs PF13976.6 EDO14410.1 - 1.5e-14 53.6 0.0 5.4e-14 51.8 0.0 2.0 2 0 0 2 2 2 1 GAG-pre-integrase domain Colipase PF01114.18 EDO14410.1 - 0.083 12.6 0.0 0.17 11.6 0.0 1.5 1 0 0 1 1 1 0 Colipase, N-terminal domain DUF5314 PF17241.2 EDO14411.1 - 7.6e-44 149.7 0.6 9.4e-44 149.4 0.6 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5314) VID27_PH PF17747.1 EDO14411.1 - 0.023 15.0 0.2 1.4 9.2 0.1 2.5 2 1 0 2 2 2 0 VID27 PH-like domain Nup160 PF11715.8 EDO14413.1 - 2.1e-18 66.3 5.2 3.6e-18 65.5 5.2 1.3 1 0 0 1 1 1 1 Nucleoporin Nup120/160 NLE PF08154.12 EDO14413.1 - 0.02 15.4 0.2 0.34 11.5 0.0 3.3 2 0 0 2 2 2 0 NLE (NUC135) domain Striatin PF08232.12 EDO14414.1 - 9.2e-19 68.6 0.6 9.2e-19 68.6 0.6 2.9 2 1 2 4 4 4 2 Striatin family Mto2_bdg PF12808.7 EDO14414.1 - 0.064 13.6 0.9 0.17 12.2 0.9 1.8 1 0 0 1 1 1 0 Micro-tubular organiser Mto1 C-term Mto2-binding region DUF5109 PF17134.4 EDO14414.1 - 0.092 12.7 0.5 6.6 6.7 0.0 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF5109) bZIP_1 PF00170.21 EDO14414.1 - 9.2 6.5 7.3 0.89 9.7 1.8 2.2 2 0 0 2 2 2 0 bZIP transcription factor Eisosome1 PF12757.7 EDO14415.1 - 1.1e-15 58.0 0.8 1.1e-15 58.0 0.8 4.3 2 2 1 3 3 3 1 Eisosome protein 1 FAM184 PF15665.5 EDO14415.1 - 2.6 7.8 48.3 0.024 14.4 26.2 2.6 1 1 1 2 2 2 0 Family with sequence similarity 184, A and B Proteasome PF00227.26 EDO14416.1 - 1.7e-48 164.7 0.1 2.2e-48 164.3 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Pr_beta_C PF12465.8 EDO14416.1 - 3e-15 55.3 0.0 3e-15 55.3 0.0 1.7 2 0 0 2 2 2 1 Proteasome beta subunits C terminal TRAPPC9-Trs120 PF08626.11 EDO14417.1 - 0 1020.4 25.0 0 1020.1 25.0 1.0 1 0 0 1 1 1 1 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit DUF3034 PF11231.8 EDO14417.1 - 0.02 14.5 0.0 0.042 13.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3034) YjcB PF15940.5 EDO14417.1 - 0.052 13.7 0.0 0.14 12.3 0.0 1.7 1 0 0 1 1 1 0 Family of unknown function LSM PF01423.22 EDO14418.1 - 1.3e-13 50.4 0.1 1.5e-13 50.2 0.1 1.1 1 0 0 1 1 1 1 LSM domain Hfq PF17209.3 EDO14418.1 - 0.0046 16.6 0.1 0.0074 15.9 0.1 1.4 1 0 0 1 1 1 1 Hfq protein Xpo1 PF08389.12 EDO14419.1 - 2.5e-23 82.8 4.0 2.5e-23 82.8 4.0 3.1 4 0 0 4 4 4 1 Exportin 1-like protein IBN_N PF03810.19 EDO14419.1 - 1.3e-07 31.4 0.9 3.7e-06 26.8 0.2 3.1 2 0 0 2 2 2 1 Importin-beta N-terminal domain MutS_II PF05188.17 EDO14419.1 - 0.09 13.1 1.1 4.1 7.7 0.0 3.5 4 0 0 4 4 4 0 MutS domain II ABC2_membrane PF01061.24 EDO14420.1 - 3.3e-08 33.2 1.3 3.3e-08 33.2 1.3 2.1 2 0 0 2 2 2 1 ABC-2 type transporter PDR_CDR PF06422.12 EDO14420.1 - 0.0011 18.8 0.5 0.0022 17.9 0.5 1.5 1 0 0 1 1 1 1 CDR ABC transporter Flocculin PF00624.18 EDO14421.1 - 5.5e-278 897.0 780.0 9.2e-13 48.2 25.5 24.8 25 0 0 25 25 25 24 Flocculin repeat Bacteroid_pep PF14406.6 EDO14421.1 - 4.2e-11 43.0 119.6 17 5.9 0.3 22.2 23 0 0 23 23 23 21 Ribosomally synthesized peptide in Bacteroidetes SDH_C PF18317.1 EDO14421.1 - 1.6e-09 37.4 17.0 1.5e+02 2.3 0.0 17.6 21 0 0 21 21 21 0 Shikimate 5'-dehydrogenase C-terminal domain DUF5314 PF17241.2 EDO14423.1 - 9.9e-31 106.9 0.1 1.1e-30 106.7 0.1 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF5314) PTB PF08416.13 EDO14423.1 - 0.099 12.8 0.0 0.16 12.1 0.0 1.4 1 0 0 1 1 1 0 Phosphotyrosine-binding domain SUR7 PF06687.12 EDO14424.1 - 1.2e-28 100.2 14.0 1.5e-28 99.9 14.0 1.1 1 0 0 1 1 1 1 SUR7/PalI family Tetraspanin PF00335.20 EDO14424.1 - 0.0067 16.2 0.8 0.011 15.5 0.8 1.5 1 0 0 1 1 1 1 Tetraspanin family Cdc13_OB2 PF18691.1 EDO14425.1 - 9.8e-42 141.5 0.2 9.8e-42 141.5 0.2 3.1 4 1 1 5 5 5 1 Cell division control protein 13, OB2 domain POT1 PF02765.17 EDO14425.1 - 1.2e-24 86.8 1.8 3.7e-24 85.2 1.8 1.9 1 0 0 1 1 1 1 Telomeric single stranded DNA binding POT1/CDC13 Cdc13_OB4_dimer PF18233.1 EDO14425.1 - 1.7e-12 47.5 8.6 1.2e-09 38.3 5.2 3.6 2 1 0 2 2 2 2 Cdc13 OB4 dimerization domain Flocculin PF00624.18 EDO14426.1 - 1.4e-09 38.0 38.6 3.3e-06 27.2 17.4 4.4 4 1 1 5 5 5 2 Flocculin repeat Period_C PF12114.8 EDO14426.1 - 0.16 11.6 2.2 0.22 11.1 2.2 1.2 1 0 0 1 1 1 0 Period protein 2/3C-terminal region PMT PF02366.18 EDO14427.1 - 1.6e-88 296.5 15.1 1.8e-88 296.3 15.1 1.0 1 0 0 1 1 1 1 Dolichyl-phosphate-mannose-protein mannosyltransferase DUF3678 PF12435.8 EDO14427.1 - 0.068 12.6 0.6 0.14 11.5 0.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3678) Med15_fungi PF05397.12 EDO14428.1 - 1.4e-31 109.0 6.5 1.4e-31 109.0 6.5 8.1 5 2 2 7 7 7 1 Mediator complex subunit 15 Gal11_ABD1 PF18535.1 EDO14428.1 - 1.2e-24 86.2 72.0 1.2e-24 86.2 72.0 9.7 3 3 2 6 6 6 1 Gal11 activator-binding domain (ABD1) KIX_2 PF16987.5 EDO14428.1 - 2.9e-19 68.8 1.9 2.9e-19 68.8 1.9 6.2 6 1 0 6 6 6 1 KIX domain EI24 PF07264.11 EDO14429.1 - 8e-05 23.0 8.8 0.00011 22.5 8.8 1.2 1 0 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) OppC_N PF12911.7 EDO14429.1 - 9.2 6.3 11.7 3.3 7.8 0.7 2.4 2 0 0 2 2 2 0 N-terminal TM domain of oligopeptide transport permease C Trypan_PARP PF05887.11 EDO14430.1 - 0.00014 21.8 20.4 0.00027 20.9 20.4 1.4 1 0 0 1 1 1 1 Procyclic acidic repetitive protein (PARP) EI24 PF07264.11 EDO14430.1 - 0.00025 21.3 7.6 0.00055 20.2 7.6 1.5 1 1 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) TRAPP PF04051.16 EDO14430.1 - 0.058 13.1 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 Transport protein particle (TRAPP) component Zip PF02535.22 EDO14430.1 - 0.24 10.6 7.0 0.048 12.9 3.3 1.7 2 0 0 2 2 2 0 ZIP Zinc transporter DUF3391 PF11871.8 EDO14430.1 - 0.82 10.2 7.3 1.2 9.7 7.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3391) Endostatin PF06482.11 EDO14430.1 - 0.84 9.0 3.9 1.2 8.5 3.9 1.2 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin DUF5314 PF17241.2 EDO14431.1 - 2.4e-79 265.6 0.2 2.4e-79 265.6 0.2 2.0 2 0 0 2 2 2 1 Family of unknown function (DUF5314) Sir1 PF11603.8 EDO14431.1 - 4.2e-06 27.2 3.3 4.2e-06 27.2 3.3 2.7 2 1 0 2 2 2 1 Regulatory protein Sir1 eIF3g PF12353.8 EDO14431.1 - 0.0017 18.7 0.7 0.0034 17.8 0.7 1.5 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit G Glyco_hydro_32N PF00251.20 EDO14432.1 - 2.1e-86 290.3 7.8 2.8e-86 289.8 7.8 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 32 N-terminal domain Glyco_hydro_32C PF08244.12 EDO14432.1 - 3.9e-12 46.4 0.9 7.4e-12 45.5 0.9 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 32 C terminal SIL1 PF16782.5 EDO14433.1 - 4.5e-103 344.5 16.2 8.8e-103 343.5 16.2 1.5 1 0 0 1 1 1 1 Nucleotide exchange factor SIL1 TSNAXIP1_N PF15739.5 EDO14433.1 - 0.058 13.8 0.3 0.65 10.4 0.1 2.8 2 0 0 2 2 2 0 Translin-associated factor X-interacting N-terminus Macoilin PF09726.9 EDO14433.1 - 0.66 8.5 35.5 0.027 13.1 29.7 1.5 2 0 0 2 2 2 0 Macoilin family SOG2 PF10428.9 EDO14433.1 - 1.4 8.1 37.9 2.9 7.0 37.4 1.7 2 0 0 2 2 2 0 RAM signalling pathway protein COMPASS-Shg1 PF05205.12 EDO14433.1 - 3.9 8.2 7.3 0.36 11.6 1.0 2.5 2 1 0 2 2 2 0 COMPASS (Complex proteins associated with Set1p) component shg1 Menin PF05053.13 EDO14433.1 - 4.1 5.7 22.6 6 5.1 22.6 1.2 1 0 0 1 1 1 0 Menin B56 PF01603.20 EDO14434.1 - 1.4e-171 571.1 8.8 2.4e-171 570.3 8.8 1.3 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) SOBP PF15279.6 EDO14434.1 - 0.96 10.0 10.6 1.6 9.3 10.6 1.5 1 0 0 1 1 1 0 Sine oculis-binding protein EMP24_GP25L PF01105.24 EDO14435.1 - 1.2e-38 132.9 0.1 1.4e-38 132.6 0.1 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD DUF2207 PF09972.9 EDO14435.1 - 0.01 14.7 0.7 0.014 14.1 0.7 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF2569 PF10754.9 EDO14435.1 - 0.047 14.1 0.3 0.087 13.3 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2569) Ribosomal_S30AE PF02482.19 EDO14435.1 - 0.16 12.7 0.7 0.28 12.0 0.7 1.6 1 1 0 1 1 1 0 Sigma 54 modulation protein / S30EA ribosomal protein TP6A_N PF04406.14 EDO14436.1 - 3.2e-13 49.4 0.4 1.5e-12 47.3 0.1 2.2 2 0 0 2 2 2 1 Type IIB DNA topoisomerase Pet127 PF08634.10 EDO14437.1 - 3.9e-104 347.9 2.4 7.5e-104 347.0 2.4 1.5 1 0 0 1 1 1 1 Mitochondrial protein Pet127 Cyclin PF08613.11 EDO14438.1 - 7.6e-15 55.6 0.3 7.6e-15 55.6 0.3 3.0 2 1 0 2 2 2 1 Cyclin BAH PF01426.18 EDO14439.1 - 5.6e-11 42.4 1.6 1.3e-10 41.2 0.2 2.2 2 0 0 2 2 2 1 BAH domain PHD PF00628.29 EDO14439.1 - 4.2e-05 23.3 14.5 4.2e-05 23.3 14.5 3.0 3 0 0 3 3 3 1 PHD-finger C1_1 PF00130.22 EDO14439.1 - 0.00046 20.0 7.8 0.00046 20.0 7.8 2.7 3 0 0 3 3 3 1 Phorbol esters/diacylglycerol binding domain (C1 domain) PCAF_N PF06466.11 EDO14439.1 - 0.0036 16.9 0.1 0.0084 15.7 0.1 1.5 1 0 0 1 1 1 1 PCAF (P300/CBP-associated factor) N-terminal domain PHD_2 PF13831.6 EDO14439.1 - 0.46 10.1 13.7 0.019 14.5 5.0 3.0 3 0 0 3 3 3 0 PHD-finger zf-HC5HC2H PF13771.6 EDO14439.1 - 9.2 6.6 10.5 4.6 7.6 3.4 3.5 4 0 0 4 4 4 0 PHD-like zinc-binding domain mRNA_cap_enzyme PF01331.19 EDO14440.1 - 1.9e-64 217.1 0.1 3.7e-64 216.2 0.1 1.5 1 0 0 1 1 1 1 mRNA capping enzyme, catalytic domain mRNA_cap_C PF03919.15 EDO14440.1 - 5.6e-31 107.4 0.4 5.6e-31 107.4 0.4 2.1 2 0 0 2 2 2 1 mRNA capping enzyme, C-terminal domain DNA_ligase_A_M PF01068.21 EDO14440.1 - 1.1e-05 25.2 0.5 0.0032 17.1 0.0 2.7 2 1 0 2 2 2 1 ATP dependent DNA ligase domain DAP3 PF10236.9 EDO14441.1 - 3.2e-95 318.9 1.7 4e-95 318.6 1.7 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal death-associated protein 3 AAA_16 PF13191.6 EDO14441.1 - 2.5e-05 24.7 0.0 5.9e-05 23.5 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EDO14441.1 - 2.8e-05 24.4 0.0 0.00019 21.7 0.0 2.2 1 1 0 1 1 1 1 AAA domain AAA PF00004.29 EDO14441.1 - 0.00029 21.3 0.5 0.003 18.0 0.5 2.2 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) T2SSE PF00437.20 EDO14441.1 - 0.0061 15.7 0.0 0.0093 15.0 0.0 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein NTPase_1 PF03266.15 EDO14441.1 - 0.0094 15.9 0.3 0.044 13.7 0.0 2.3 4 0 0 4 4 4 1 NTPase DUF2075 PF09848.9 EDO14441.1 - 0.012 14.9 0.0 0.023 13.9 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_7 PF12775.7 EDO14441.1 - 0.016 14.7 0.0 0.039 13.5 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region NACHT PF05729.12 EDO14441.1 - 0.019 14.9 0.1 0.14 12.1 0.0 2.5 3 0 0 3 3 3 0 NACHT domain NB-ARC PF00931.22 EDO14441.1 - 0.029 13.6 0.1 0.07 12.3 0.1 1.6 1 0 0 1 1 1 0 NB-ARC domain Sigma54_activat PF00158.26 EDO14441.1 - 0.032 14.0 0.0 0.062 13.0 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_30 PF13604.6 EDO14441.1 - 0.044 13.5 0.0 0.072 12.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.6 EDO14441.1 - 0.057 13.8 0.0 0.14 12.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain MCM PF00493.23 EDO14441.1 - 0.075 12.1 0.0 0.15 11.2 0.0 1.4 1 0 0 1 1 1 0 MCM P-loop domain AAA_29 PF13555.6 EDO14441.1 - 0.083 12.6 0.1 1.6 8.5 0.0 2.4 2 0 0 2 2 2 0 P-loop containing region of AAA domain PseudoU_synth_1 PF01416.20 EDO14442.1 - 1.5e-12 47.9 0.0 5.6e-11 42.9 0.0 2.7 3 0 0 3 3 3 1 tRNA pseudouridine synthase DUF2344 PF10105.9 EDO14442.1 - 0.015 15.1 0.8 0.18 11.7 0.0 2.5 2 1 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2344) RRM_1 PF00076.22 EDO14443.1 - 1.8e-30 104.6 1.8 7.4e-17 60.9 0.1 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 EDO14443.1 - 0.00068 19.7 0.2 0.26 11.4 0.0 2.5 2 1 0 2 2 2 2 Limkain b1 RRM_5 PF13893.6 EDO14443.1 - 0.0007 19.2 0.5 0.097 12.3 0.2 2.1 1 1 1 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EDO14443.1 - 0.0073 16.4 0.1 1.4 9.0 0.0 2.5 2 1 0 2 2 2 1 RNA recognition motif RRM_occluded PF16842.5 EDO14443.1 - 0.017 14.9 0.0 3 7.8 0.0 2.3 2 0 0 2 2 2 0 Occluded RNA-recognition motif DASH_Spc34 PF08657.10 EDO14443.1 - 0.028 14.2 0.9 0.036 13.9 0.9 1.1 1 0 0 1 1 1 0 DASH complex subunit Spc34 PHM7_cyt PF14703.6 EDO14443.1 - 0.033 14.4 0.2 0.21 11.8 0.1 2.0 1 1 0 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter SET_assoc PF11767.8 EDO14443.1 - 0.052 13.2 0.5 1.3 8.7 0.0 2.3 2 0 0 2 2 2 0 Histone lysine methyltransferase SET associated Tli4_N PF18443.1 EDO14443.1 - 0.064 13.6 0.7 0.088 13.2 0.7 1.4 1 1 0 1 1 1 0 Tle cognate immunity protein 4 N-terminal domain CTNNBL PF08216.11 EDO14443.1 - 0.094 12.9 1.1 0.29 11.3 0.1 2.2 2 1 0 2 2 2 0 Catenin-beta-like, Arm-motif containing nuclear AMP-binding PF00501.28 EDO14444.1 - 5.4e-91 305.3 0.1 7.2e-91 304.9 0.1 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EDO14444.1 - 0.0012 19.7 0.2 0.02 15.9 0.0 2.7 3 0 0 3 3 3 1 AMP-binding enzyme C-terminal domain DUF1106 PF06523.11 EDO14444.1 - 0.025 14.6 1.2 0.22 11.6 0.3 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1106) HTH_40 PF14493.6 EDO14444.1 - 0.04 14.4 0.0 0.13 12.7 0.0 1.9 1 0 0 1 1 1 0 Helix-turn-helix domain COX6B PF02297.17 EDO14445.1 - 2.6e-20 72.4 8.1 3.2e-20 72.1 8.1 1.1 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb SUN PF03856.13 EDO14446.1 - 1.5e-79 266.9 14.4 1.8e-79 266.7 14.4 1.0 1 0 0 1 1 1 1 Beta-glucosidase (SUN family) DUF333 PF03891.15 EDO14446.1 - 0.057 13.6 2.5 0.58 10.4 0.3 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF333) RVT_2 PF07727.14 EDO14448.1 - 3.8e-54 183.9 0.0 4.9e-54 183.5 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF4422 PF14393.6 EDO14450.1 - 0.068 13.0 0.5 0.084 12.7 0.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4422) rve PF00665.26 EDO14451.1 - 1.8e-14 54.0 0.0 9.9e-14 51.6 0.0 2.0 2 0 0 2 2 2 1 Integrase core domain MLVIN_C PF18697.1 EDO14451.1 - 0.00028 20.9 0.1 0.00069 19.7 0.1 1.7 1 0 0 1 1 1 1 Murine leukemia virus (MLV) integrase (IN) C-terminal domain Cnd1 PF12717.7 EDO14451.1 - 0.11 12.5 0.3 9.3 6.3 0.0 2.3 2 0 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1 Fungal_trans PF04082.18 EDO14452.1 - 1.3e-25 90.0 0.1 1.3e-25 90.0 0.1 1.7 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDO14452.1 - 1.5e-07 31.4 13.4 2.6e-07 30.6 13.4 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain NYD-SP28 PF14772.6 EDO14452.1 - 6.6 6.8 8.2 1.1 9.3 0.2 3.1 3 0 0 3 3 3 0 Sperm tail FMO-like PF00743.19 EDO14453.1 - 1.1e-40 139.6 3.8 1.8e-36 125.7 0.8 2.1 1 1 1 2 2 2 2 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.14 EDO14453.1 - 7e-15 55.0 0.0 1.5e-14 53.9 0.0 1.5 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EDO14453.1 - 1.4e-12 47.5 8.5 2.6e-10 40.0 8.5 2.9 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EDO14453.1 - 7.5e-11 42.2 0.1 6.6e-09 35.9 0.0 3.0 2 1 0 2 2 2 1 FAD-NAD(P)-binding K_oxygenase PF13434.6 EDO14453.1 - 1.8e-07 30.7 0.3 2.7e-06 26.8 0.0 2.4 2 1 1 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 EDO14453.1 - 4.8e-07 29.9 0.0 1.1e-06 28.8 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EDO14453.1 - 5.9e-05 22.8 0.0 0.44 10.1 0.0 2.7 3 0 0 3 3 3 2 FAD dependent oxidoreductase HI0933_like PF03486.14 EDO14453.1 - 0.00017 20.4 0.0 0.039 12.7 0.2 2.9 3 0 0 3 3 3 1 HI0933-like protein Thi4 PF01946.17 EDO14453.1 - 0.0003 20.1 0.1 0.0069 15.7 0.0 2.2 2 0 0 2 2 2 1 Thi4 family Pyr_redox PF00070.27 EDO14453.1 - 0.01 16.4 0.5 1.3 9.7 0.0 3.1 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase DUF4920 PF16267.5 EDO14453.1 - 0.023 14.6 0.4 0.07 13.1 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4920) Amino_oxidase PF01593.24 EDO14453.1 - 0.073 12.3 0.0 2.4 7.4 0.0 2.5 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase FAD_oxidored PF12831.7 EDO14453.1 - 0.1 11.9 0.0 0.24 10.7 0.0 1.7 2 0 0 2 2 2 0 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 EDO14453.1 - 0.18 10.8 0.0 0.38 9.7 0.0 1.7 2 0 0 2 2 2 0 Lycopene cyclase protein FAD_binding_3 PF01494.19 EDO14453.1 - 0.21 10.8 0.0 1.5 7.9 0.0 2.0 2 0 0 2 2 2 0 FAD binding domain Ctr PF04145.15 EDO14454.1 - 9.4e-23 81.5 16.1 5.2e-20 72.6 16.1 2.1 1 1 0 1 1 1 1 Ctr copper transporter family Enolase_C PF00113.22 EDO14455.1 - 2.2e-145 483.5 0.0 2.6e-145 483.2 0.0 1.0 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain MR_MLE_C PF13378.6 EDO14455.1 - 3.3e-07 30.1 0.0 4.8e-07 29.6 0.0 1.3 1 0 0 1 1 1 1 Enolase C-terminal domain-like MAAL_C PF07476.11 EDO14455.1 - 0.0074 15.5 0.1 0.011 15.0 0.1 1.2 1 0 0 1 1 1 1 Methylaspartate ammonia-lyase C-terminus Sir1 PF11603.8 EDO14456.1 - 5.4e-34 117.2 6.3 5.4e-34 117.2 6.3 2.8 2 0 0 2 2 2 1 Regulatory protein Sir1 Helicase_C PF00271.31 EDO14456.1 - 1.4e-16 60.8 0.5 1.4e-16 60.8 0.5 3.0 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DEAD PF00270.29 EDO14456.1 - 5.9e-08 32.7 0.0 4.2e-07 29.9 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.15 EDO14456.1 - 0.0002 21.4 0.2 0.0035 17.3 0.0 2.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Terminase_6 PF03237.15 EDO14456.1 - 0.094 12.4 0.1 0.25 11.0 0.1 1.7 1 0 0 1 1 1 0 Terminase-like family Mon1 PF03164.14 EDO14459.1 - 1.2e-138 462.7 9.0 1.7e-138 462.1 9.0 1.3 1 0 0 1 1 1 1 Trafficking protein Mon1 GIY-YIG PF01541.24 EDO14460.1 - 4.8e-13 49.2 0.3 9.8e-13 48.2 0.3 1.5 1 0 0 1 1 1 1 GIY-YIG catalytic domain FANCL_C PF11793.8 EDO14460.1 - 0.00028 21.0 8.9 0.00068 19.8 8.9 1.6 1 0 0 1 1 1 1 FANCL C-terminal domain BDV_P24 PF06595.11 EDO14460.1 - 0.092 12.6 0.6 0.15 12.0 0.6 1.2 1 0 0 1 1 1 0 Borna disease virus P24 protein AAA_2 PF07724.14 EDO14461.1 - 3.6e-35 121.6 3.0 1.4e-34 119.6 3.0 1.9 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA PF00004.29 EDO14461.1 - 2.6e-14 53.8 0.4 6.3e-14 52.5 0.4 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ClpB_D2-small PF10431.9 EDO14461.1 - 2e-08 34.2 0.0 8e-08 32.2 0.0 2.0 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA_5 PF07728.14 EDO14461.1 - 8.7e-08 32.3 0.1 3.4e-07 30.4 0.1 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 EDO14461.1 - 2.4e-05 23.8 0.0 0.014 14.8 0.0 2.8 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI AAA_22 PF13401.6 EDO14461.1 - 5.5e-05 23.5 0.5 0.0026 18.0 0.5 2.8 1 1 0 1 1 1 1 AAA domain Sigma54_activ_2 PF14532.6 EDO14461.1 - 9e-05 22.6 0.0 0.0002 21.5 0.0 1.6 1 0 0 1 1 1 1 Sigma-54 interaction domain Sigma54_activat PF00158.26 EDO14461.1 - 9.9e-05 22.1 0.0 0.04 13.6 0.0 2.5 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_16 PF13191.6 EDO14461.1 - 0.00024 21.5 0.4 0.0021 18.5 0.2 2.5 1 1 1 2 2 1 1 AAA ATPase domain RuvB_N PF05496.12 EDO14461.1 - 0.00026 20.7 0.5 0.0049 16.6 0.2 2.9 2 1 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain MCM PF00493.23 EDO14461.1 - 0.00067 18.8 0.2 0.0017 17.5 0.2 1.6 1 0 0 1 1 1 1 MCM P-loop domain AAA_24 PF13479.6 EDO14461.1 - 0.00068 19.4 2.7 0.0008 19.2 1.0 2.0 2 1 0 2 2 2 1 AAA domain T2SSE PF00437.20 EDO14461.1 - 0.0023 17.0 0.0 0.0056 15.8 0.0 1.6 1 0 0 1 1 1 1 Type II/IV secretion system protein IstB_IS21 PF01695.17 EDO14461.1 - 0.0039 17.0 0.0 0.0097 15.7 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein DEAD PF00270.29 EDO14461.1 - 0.0043 16.8 2.9 0.069 12.9 0.0 3.3 3 1 1 4 4 4 1 DEAD/DEAH box helicase AAA_14 PF13173.6 EDO14461.1 - 0.0072 16.4 1.5 0.015 15.4 0.1 2.4 2 0 0 2 2 2 1 AAA domain AAA_23 PF13476.6 EDO14461.1 - 0.008 16.7 7.5 0.008 16.7 7.5 3.1 2 1 1 3 3 2 1 AAA domain AAA_7 PF12775.7 EDO14461.1 - 0.0088 15.6 0.0 0.015 14.8 0.0 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region NACHT PF05729.12 EDO14461.1 - 0.0099 15.8 0.1 0.34 10.8 0.0 2.5 2 0 0 2 2 2 1 NACHT domain AAA_33 PF13671.6 EDO14461.1 - 0.018 15.2 0.0 0.063 13.4 0.0 2.0 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 EDO14461.1 - 0.022 14.2 0.0 0.049 13.1 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein AAA_29 PF13555.6 EDO14461.1 - 0.028 14.1 0.0 0.072 12.8 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain SMC_N PF02463.19 EDO14461.1 - 0.035 13.5 0.2 0.18 11.2 0.0 2.2 2 1 0 2 2 2 0 RecF/RecN/SMC N terminal domain AAA_18 PF13238.6 EDO14461.1 - 0.037 14.6 0.1 0.12 12.9 0.1 2.0 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EDO14461.1 - 0.039 14.3 0.7 0.31 11.4 0.2 2.6 2 1 0 2 2 2 0 RNA helicase ResIII PF04851.15 EDO14461.1 - 0.041 13.9 4.1 0.095 12.7 1.7 2.8 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit TsaE PF02367.17 EDO14461.1 - 0.084 12.9 0.0 0.2 11.7 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ABC_tran PF00005.27 EDO14461.1 - 0.16 12.5 0.2 0.16 12.5 0.2 2.2 2 1 1 3 3 1 0 ABC transporter Methyltransf_11 PF08241.12 EDO14462.1 - 4.6e-06 27.2 0.0 1.2e-05 25.8 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EDO14462.1 - 1.9e-05 24.6 0.0 4.1e-05 23.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDO14462.1 - 0.0023 18.6 0.0 0.0054 17.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain SR-25 PF10500.9 EDO14462.1 - 0.18 11.4 24.1 0.3 10.7 7.8 2.3 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein DUF4614 PF15391.6 EDO14462.1 - 1.8 8.5 22.3 3.4 7.6 9.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4614) MTHFR PF02219.17 EDO14463.1 - 9.3e-85 284.4 0.0 1.9e-84 283.4 0.0 1.5 1 1 0 1 1 1 1 Methylenetetrahydrofolate reductase UBA PF00627.31 EDO14465.1 - 2.7e-16 59.1 0.2 7.5e-11 41.7 0.1 2.4 2 0 0 2 2 2 2 UBA/TS-N domain UCH PF00443.29 EDO14465.1 - 7.6e-16 58.4 0.1 9e-16 58.1 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EDO14465.1 - 1.9e-09 37.6 0.3 3e-09 36.9 0.2 1.2 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Wtap PF17098.5 EDO14466.1 - 7.4e-07 29.2 12.2 1.5e-06 28.2 12.2 1.4 1 0 0 1 1 1 1 WTAP/Mum2p family DAHP_synth_1 PF00793.20 EDO14467.1 - 2.1e-103 345.0 0.0 2.4e-103 344.8 0.0 1.0 1 0 0 1 1 1 1 DAHP synthetase I family ATG13 PF10033.9 EDO14469.1 - 2e-59 201.2 0.7 4e-59 200.2 0.7 1.5 1 0 0 1 1 1 1 Autophagy-related protein 13 Flocculin PF00624.18 EDO14470.1 - 1.7e-244 789.9 695.1 7.7e-13 48.5 25.5 21.8 21 1 0 21 21 21 20 Flocculin repeat Bacteroid_pep PF14406.6 EDO14470.1 - 3.1e-14 53.0 104.4 14 6.1 0.3 20.1 20 0 0 20 20 20 20 Ribosomally synthesized peptide in Bacteroidetes SDH_C PF18317.1 EDO14470.1 - 1.3e-09 37.6 12.6 1.3e+02 2.5 0.0 16.8 20 0 0 20 20 20 0 Shikimate 5'-dehydrogenase C-terminal domain Ribosomal_S10 PF00338.22 EDO14471.1 - 4.9e-31 106.9 0.0 7.8e-31 106.2 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e FtsJ PF01728.19 EDO14472.1 - 2.9e-66 222.9 0.0 3.8e-66 222.5 0.0 1.2 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_23 PF13489.6 EDO14472.1 - 0.12 12.3 0.0 0.17 11.7 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain ORC2 PF04084.14 EDO14473.1 - 2.1e-113 378.6 2.6 3e-113 378.1 2.6 1.2 1 0 0 1 1 1 1 Origin recognition complex subunit 2 Pkinase PF00069.25 EDO14474.1 - 3.1e-37 128.4 0.1 5.7e-37 127.5 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO14474.1 - 8.3e-24 84.3 0.0 1.5e-23 83.4 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EDO14474.1 - 3.7e-05 23.2 0.0 0.00021 20.7 0.0 1.8 1 1 1 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EDO14474.1 - 0.027 14.4 0.0 0.59 10.0 0.0 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EDO14474.1 - 0.034 13.1 0.0 0.034 13.1 0.0 2.4 2 0 0 2 2 2 0 Haspin like kinase domain Kinase-like PF14531.6 EDO14474.1 - 0.065 12.5 0.0 0.13 11.6 0.0 1.4 1 1 0 1 1 1 0 Kinase-like ECH_2 PF16113.5 EDO14476.1 - 3.1e-93 312.9 0.0 3.7e-93 312.7 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_1 PF00378.20 EDO14476.1 - 6.6e-26 91.1 0.2 2.2e-25 89.4 0.0 1.8 2 0 0 2 2 2 1 Enoyl-CoA hydratase/isomerase Focal_AT PF03623.13 EDO14476.1 - 0.022 14.8 0.8 0.054 13.5 0.8 1.6 1 0 0 1 1 1 0 Focal adhesion targeting region zf-UBP PF02148.19 EDO14477.1 - 6.5e-21 74.4 17.0 8.4e-21 74.1 5.1 2.7 2 0 0 2 2 2 2 Zn-finger in ubiquitin-hydrolases and other protein UCH PF00443.29 EDO14477.1 - 1.2e-19 70.8 0.2 1.2e-19 70.8 0.2 2.3 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP_var PF17807.1 EDO14477.1 - 8.7e-07 28.6 12.7 1.8e-06 27.6 7.4 3.3 2 1 0 2 2 2 1 Variant UBP zinc finger CBM_17_28 PF03424.14 EDO14477.1 - 0.058 13.1 1.0 0.13 12.0 1.0 1.5 1 0 0 1 1 1 0 Carbohydrate binding domain (family 17/28) PulA_N1 PF17999.1 EDO14477.1 - 3.1 8.6 5.5 4 8.2 0.7 3.4 1 1 2 3 3 3 0 Pullulanase N1-terminal domain LMBR1 PF04791.16 EDO14477.1 - 3.2 6.5 7.5 4.6 6.0 7.5 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Rpp20 PF12328.8 EDO14478.1 - 9.1e-28 96.9 7.1 2.6e-25 89.0 7.1 2.2 1 1 0 1 1 1 1 Rpp20 subunit of nuclear RNase MRP and P Alba PF01918.21 EDO14478.1 - 1.7e-08 34.2 0.1 2.6e-08 33.6 0.1 1.3 1 0 0 1 1 1 1 Alba Inhibitor_I71 PF12628.7 EDO14478.1 - 0.027 14.3 0.4 0.031 14.1 0.4 1.1 1 0 0 1 1 1 0 Falstatin, cysteine peptidase inhibitor Terminase_4 PF05119.12 EDO14478.1 - 0.12 12.9 0.2 0.16 12.4 0.2 1.5 1 1 0 1 1 1 0 Phage terminase, small subunit Pes-10 PF07149.11 EDO14478.1 - 7.9 5.4 13.0 5 6.1 0.0 2.0 1 1 1 2 2 2 0 Pes-10 Oxidored-like PF09791.9 EDO14479.1 - 1.6e-23 82.1 2.1 2.8e-23 81.3 2.1 1.4 1 0 0 1 1 1 1 Oxidoreductase-like protein, N-terminal HSP70 PF00012.20 EDO14480.1 - 1.6e-179 598.0 1.5 2e-179 597.7 1.5 1.1 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EDO14480.1 - 7.8e-09 34.8 0.1 1.4e-08 34.0 0.1 1.3 1 0 0 1 1 1 1 MreB/Mbl protein FtsA PF14450.6 EDO14480.1 - 0.00033 21.0 3.5 0.0033 17.8 0.9 3.0 2 2 0 2 2 2 1 Cell division protein FtsA Raco_middle PF17651.1 EDO14480.1 - 0.11 12.2 0.2 0.39 10.4 0.1 1.9 2 0 0 2 2 2 0 RACo middle region Peptidase_M22 PF00814.25 EDO14480.1 - 0.13 12.0 0.8 33 4.0 0.1 3.1 1 1 2 3 3 3 0 Glycoprotease family THOC7 PF05615.13 EDO14480.1 - 2.4 8.5 10.3 14 6.0 0.3 3.0 2 1 1 3 3 3 0 Tho complex subunit 7 NPL4 PF05021.15 EDO14481.1 - 1.8e-136 454.5 0.3 2.4e-136 454.1 0.3 1.1 1 0 0 1 1 1 1 NPL4 family zf-NPL4 PF05020.15 EDO14481.1 - 1.7e-69 232.5 0.7 2.8e-69 231.9 0.7 1.3 1 0 0 1 1 1 1 NPL4 family, putative zinc binding region UN_NPL4 PF11543.8 EDO14481.1 - 0.001 19.5 0.0 0.0037 17.7 0.0 2.0 1 1 0 1 1 1 1 Nuclear pore localisation protein NPL4 Sec66 PF09802.9 EDO14482.1 - 4.1e-68 228.5 1.2 4.7e-68 228.3 1.2 1.0 1 0 0 1 1 1 1 Preprotein translocase subunit Sec66 Tmemb_18A PF09771.9 EDO14482.1 - 0.038 14.4 0.0 0.068 13.6 0.0 1.5 1 0 0 1 1 1 0 Transmembrane protein 188 Pantoate_transf PF02548.15 EDO14483.1 - 2.5e-96 322.1 0.0 2.9e-96 321.8 0.0 1.0 1 0 0 1 1 1 1 Ketopantoate hydroxymethyltransferase PEP_mutase PF13714.6 EDO14483.1 - 0.00024 20.6 0.0 0.00038 20.0 0.0 1.3 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase YusW PF14039.6 EDO14483.1 - 0.099 13.2 0.0 2 9.0 0.0 2.3 2 0 0 2 2 2 0 YusW-like protein Lactamase_B_2 PF12706.7 EDO14484.1 - 6e-31 107.5 0.0 8.7e-31 107.0 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 EDO14484.1 - 2e-11 44.0 0.0 4.1e-11 43.0 0.0 1.6 1 1 0 1 1 1 1 Beta-lactamase superfamily domain ANAPC4_WD40 PF12894.7 EDO14485.1 - 5e-06 26.7 0.1 0.7 10.2 0.0 3.6 2 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EDO14485.1 - 1.5e-05 25.7 1.0 0.019 15.8 0.0 4.3 4 1 0 4 4 4 1 WD domain, G-beta repeat Ge1_WD40 PF16529.5 EDO14485.1 - 0.019 14.0 0.4 2.2 7.2 0.0 3.1 4 0 0 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Lactonase PF10282.9 EDO14485.1 - 0.057 12.7 0.0 0.67 9.2 0.0 2.3 1 1 0 2 2 2 0 Lactonase, 7-bladed beta-propeller tRNA-synt_1b PF00579.25 EDO14486.1 - 3.5e-06 26.6 0.0 4.8e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) DUF2423 PF10338.9 EDO14487.1 - 2.7e-17 62.7 1.9 2.7e-17 62.7 1.9 2.2 2 1 0 2 2 2 1 Protein of unknown function (DUF2423) PhetRS_B1 PF18262.1 EDO14487.1 - 0.016 15.4 0.6 0.022 15.0 0.6 1.2 1 0 0 1 1 1 0 Phe-tRNA synthetase beta subunit B1 domain Ribosomal_L19e PF01280.20 EDO14488.1 - 2.5e-59 199.5 10.3 2.5e-59 199.5 10.3 1.5 2 0 0 2 2 2 1 Ribosomal protein L19e TilS PF09179.11 EDO14488.1 - 0.32 11.5 7.0 82 3.8 7.8 3.1 2 1 0 2 2 2 0 TilS substrate binding domain FTHFS PF01268.19 EDO14489.1 - 2.5e-251 834.7 0.4 3.7e-251 834.2 0.4 1.2 1 0 0 1 1 1 1 Formate--tetrahydrofolate ligase THF_DHG_CYH_C PF02882.19 EDO14489.1 - 4.5e-71 237.3 0.5 4.5e-71 237.3 0.5 1.8 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH PF00763.23 EDO14489.1 - 5.6e-35 120.1 0.8 1.5e-34 118.7 0.8 1.8 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain OCD_Mu_crystall PF02423.15 EDO14489.1 - 0.0023 17.0 0.2 0.0046 15.9 0.2 1.4 1 0 0 1 1 1 1 Ornithine cyclodeaminase/mu-crystallin family AdoHcyase_NAD PF00670.21 EDO14489.1 - 0.017 15.2 1.5 0.41 10.7 0.5 2.7 2 1 0 2 2 2 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain Saccharop_dh_N PF04455.12 EDO14489.1 - 0.055 13.9 0.1 0.83 10.1 0.0 2.8 2 0 0 2 2 2 0 LOR/SDH bifunctional enzyme conserved region TEA PF01285.18 EDO14490.1 - 7.1e-25 86.9 0.1 1.9e-24 85.5 0.1 1.7 1 0 0 1 1 1 1 TEA/ATTS domain bZIP_2 PF07716.15 EDO14492.1 - 4.7e-05 23.4 8.9 4.7e-05 23.4 8.9 1.9 1 1 0 1 1 1 1 Basic region leucine zipper YL1 PF05764.13 EDO14492.1 - 0.014 15.6 22.7 0.019 15.1 22.7 1.3 1 0 0 1 1 1 0 YL1 nuclear protein bZIP_1 PF00170.21 EDO14492.1 - 0.023 14.8 14.3 0.05 13.7 12.5 2.3 1 1 1 2 2 2 0 bZIP transcription factor Nop14 PF04147.12 EDO14492.1 - 0.053 11.7 26.5 0.061 11.5 26.5 1.1 1 0 0 1 1 1 0 Nop14-like family SlyX PF04102.12 EDO14492.1 - 0.07 13.8 0.5 1.9 9.2 0.1 2.8 2 0 0 2 2 2 0 SlyX CDC45 PF02724.14 EDO14492.1 - 0.13 10.5 20.1 0.16 10.2 20.1 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF2457 PF10446.9 EDO14492.1 - 0.34 10.0 24.0 0.45 9.6 24.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) TSC22 PF01166.18 EDO14492.1 - 0.44 10.9 4.6 1.1 9.6 2.3 2.4 2 0 0 2 2 2 0 TSC-22/dip/bun family RPN2_C PF18004.1 EDO14492.1 - 5.3 6.9 11.5 1.6 8.6 8.7 1.6 1 1 1 2 2 2 0 26S proteasome regulatory subunit RPN2 C-terminal domain rve PF00665.26 EDO14493.1 - 2.5e-06 27.7 0.0 5.5e-06 26.6 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Minor_capsid_2 PF11114.8 EDO14493.1 - 0.029 14.4 0.4 0.098 12.7 0.1 2.0 1 1 1 2 2 2 0 Minor capsid protein MLVIN_C PF18697.1 EDO14493.1 - 0.038 14.1 0.1 0.086 12.9 0.1 1.6 1 0 0 1 1 1 0 Murine leukemia virus (MLV) integrase (IN) C-terminal domain RVT_1 PF00078.27 EDO14494.1 - 6.9e-15 55.2 0.0 1.2e-14 54.4 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 EDO14494.1 - 9e-05 22.4 0.0 0.0002 21.3 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase DUF4460 PF14687.6 EDO14494.1 - 0.0078 16.3 0.3 0.024 14.7 0.1 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4460) IIGP PF05049.13 EDO14496.1 - 0.078 12.0 0.0 0.13 11.3 0.0 1.3 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) Radial_spoke_3 PF06098.11 EDO14496.1 - 0.13 11.5 0.7 0.25 10.6 0.7 1.3 1 0 0 1 1 1 0 Radial spoke protein 3 MCM_OB PF17207.3 EDO14496.1 - 0.49 10.2 6.4 1.1 9.1 6.4 1.5 1 0 0 1 1 1 0 MCM OB domain Retrotrans_gag PF03732.17 EDO14497.1 - 4.3e-07 30.1 0.1 9.6e-07 29.0 0.1 1.7 1 0 0 1 1 1 1 Retrotransposon gag protein zf-CCHC PF00098.23 EDO14497.1 - 7.1e-05 22.7 2.4 0.00013 21.8 2.4 1.5 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_2 PF13696.6 EDO14497.1 - 0.09 12.6 1.9 0.14 12.0 1.9 1.4 1 0 0 1 1 1 0 Zinc knuckle Helicase_C PF00271.31 EDO14498.1 - 5.3e-17 62.2 0.0 6.8e-17 61.8 0.0 1.2 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ERCC3_RAD25_C PF16203.5 EDO14498.1 - 0.002 17.4 0.0 0.0025 17.1 0.0 1.1 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase Terminase_6 PF03237.15 EDO14498.1 - 0.03 14.0 0.0 0.035 13.8 0.0 1.1 1 0 0 1 1 1 0 Terminase-like family Helicase_C_2 PF13307.6 EDO14498.1 - 0.14 12.4 0.0 0.16 12.1 0.0 1.2 1 0 0 1 1 1 0 Helicase C-terminal domain Sugar_tr PF00083.24 EDO14501.1 - 6.1e-104 348.4 22.2 7.3e-104 348.1 22.2 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDO14501.1 - 6.9e-24 84.4 21.6 6.9e-24 84.4 21.6 2.4 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EDO14502.1 - 2.1e-107 359.8 26.6 3.4e-107 359.1 26.6 1.3 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDO14502.1 - 4.7e-28 98.1 27.9 6.3e-27 94.4 20.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF2373 PF10180.9 EDO14503.1 - 2.2e-25 88.2 0.9 5.2e-25 87.1 0.9 1.7 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2373) DAG_kinase_N PF14513.6 EDO14503.1 - 0.0026 18.0 4.0 0.0026 18.0 4.0 2.2 2 0 0 2 2 2 2 Diacylglycerol kinase N-terminus Ku_C PF03730.14 EDO14503.1 - 0.025 15.3 6.4 0.025 15.3 6.4 3.0 2 1 1 3 3 3 0 Ku70/Ku80 C-terminal arm Peptidase_S49_N PF08496.10 EDO14503.1 - 1.9 8.5 15.7 1.4 9.0 4.6 2.2 2 0 0 2 2 2 0 Peptidase family S49 N-terminal YlqD PF11068.8 EDO14503.1 - 2.2 8.7 14.5 2.4 8.6 6.3 2.5 2 0 0 2 2 2 0 YlqD protein RasGAP PF00616.19 EDO14504.1 - 2.4e-33 115.6 5.9 5.1e-32 111.3 5.9 2.6 1 1 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase C2 PF00168.30 EDO14504.1 - 0.00037 20.7 0.0 0.00092 19.5 0.0 1.7 1 0 0 1 1 1 1 C2 domain CRAL_TRIO PF00650.20 EDO14505.1 - 2.8e-35 121.4 0.0 4.5e-35 120.7 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 EDO14505.1 - 4.2e-09 36.4 0.0 9.4e-09 35.3 0.0 1.6 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.6 EDO14505.1 - 0.0077 16.4 0.1 0.012 15.8 0.1 1.4 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain ALAD PF00490.21 EDO14506.1 - 7.2e-118 393.4 0.0 8.5e-118 393.1 0.0 1.0 1 0 0 1 1 1 1 Delta-aminolevulinic acid dehydratase ADH_N PF08240.12 EDO14507.1 - 1.4e-24 86.0 8.2 2.5e-24 85.2 8.2 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EDO14507.1 - 7.3e-17 61.6 0.0 1.4e-16 60.6 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 EDO14507.1 - 7.6e-07 28.7 0.4 1.7e-06 27.5 0.3 1.5 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.21 EDO14507.1 - 0.00011 21.6 0.0 0.00022 20.6 0.0 1.5 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain DUF364 PF04016.12 EDO14507.1 - 0.00074 19.1 0.0 0.0014 18.2 0.0 1.4 1 0 0 1 1 1 1 Putative heavy-metal chelation NAD_binding_2 PF03446.15 EDO14507.1 - 0.014 15.6 0.1 0.021 15.0 0.1 1.3 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase ApbA PF02558.16 EDO14507.1 - 0.065 12.9 0.0 0.1 12.2 0.0 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Hexapep_2 PF14602.6 EDO14507.1 - 0.079 12.7 2.9 0.072 12.9 1.2 1.9 2 0 0 2 2 2 0 Hexapeptide repeat of succinyl-transferase Fer4_10 PF13237.6 EDO14507.1 - 0.11 12.6 3.5 3.1 8.0 0.4 2.4 2 0 0 2 2 2 0 4Fe-4S dicluster domain RseC_MucC PF04246.12 EDO14507.1 - 4.3 7.3 6.0 9.6 6.2 6.0 1.7 1 1 0 1 1 1 0 Positive regulator of sigma(E), RseC/MucC Mak10 PF04112.13 EDO14508.1 - 2e-42 144.5 0.3 6.1e-42 143.0 0.2 1.9 2 0 0 2 2 2 1 Mak10 subunit, NatC N(alpha)-terminal acetyltransferase Citrate_ly_lig PF08218.11 EDO14508.1 - 0.092 12.4 0.8 0.56 9.8 0.1 2.7 2 1 1 3 3 3 0 Citrate lyase ligase C-terminal domain TNRC6-PABC_bdg PF16608.5 EDO14508.1 - 0.17 11.5 0.0 0.27 10.9 0.0 1.3 1 0 0 1 1 1 0 TNRC6-PABC binding domain TPR_8 PF13181.6 EDO14509.1 - 2.2e-06 27.4 0.0 0.0011 19.0 0.0 4.4 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_14 PF13428.6 EDO14509.1 - 7.6e-05 23.2 0.0 0.65 11.0 0.0 4.7 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_15 PF13429.6 EDO14509.1 - 0.00065 19.0 1.0 0.061 12.5 0.0 3.3 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_2 PF07719.17 EDO14509.1 - 0.00091 19.2 0.0 0.0091 16.0 0.0 2.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.6 EDO14509.1 - 0.0059 16.9 4.4 3.1 8.4 0.0 4.7 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_1 PF00515.28 EDO14509.1 - 0.015 15.1 0.0 0.4 10.6 0.1 3.4 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_12 PF13424.6 EDO14509.1 - 0.041 14.2 0.0 3.7 7.9 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat Cas6b_C PF17262.2 EDO14509.1 - 0.07 13.2 2.0 0.14 12.3 0.2 2.5 2 0 0 2 2 2 0 Cas6b C-terminal domain Suf PF05843.14 EDO14509.1 - 0.086 12.8 4.3 4.3 7.2 0.2 3.9 3 1 0 3 3 3 0 Suppressor of forked protein (Suf) TPR_11 PF13414.6 EDO14509.1 - 0.12 12.1 0.1 1.1 8.9 0.0 2.7 3 0 0 3 3 3 0 TPR repeat TPR_16 PF13432.6 EDO14509.1 - 0.13 12.9 0.0 0.68 10.6 0.0 2.2 3 0 0 3 3 2 0 Tetratricopeptide repeat NRDE-2 PF08424.10 EDO14509.1 - 0.43 9.6 16.8 0.6 9.2 2.7 5.0 3 2 0 4 4 4 0 NRDE-2, necessary for RNA interference Carn_acyltransf PF00755.20 EDO14510.1 - 8.1e-180 599.3 3.4 9.4e-180 599.1 3.4 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase ICMT PF04140.14 EDO14511.1 - 4.2e-30 104.0 0.4 8.1e-30 103.1 0.4 1.5 1 0 0 1 1 1 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.13 EDO14511.1 - 2.1e-13 50.6 3.2 2.1e-13 50.6 3.2 1.8 2 0 0 2 2 2 1 Phospholipid methyltransferase DUF1295 PF06966.12 EDO14511.1 - 9.1e-05 22.1 1.0 0.00012 21.7 1.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) NnrU PF07298.11 EDO14511.1 - 0.004 16.7 2.2 0.008 15.7 2.3 1.5 1 1 0 1 1 1 1 NnrU protein Rab5ip PF07019.12 EDO14511.1 - 0.046 14.3 12.0 0.88 10.2 11.5 2.5 1 1 1 2 2 2 0 Rab5-interacting protein (Rab5ip) PINIT PF14324.6 EDO14512.1 - 8.2e-31 107.3 0.4 2.6e-30 105.7 0.4 2.0 1 0 0 1 1 1 1 PINIT domain zf-MIZ PF02891.20 EDO14512.1 - 5.9e-22 77.2 7.3 1e-21 76.4 7.3 1.4 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger SAP PF02037.27 EDO14512.1 - 2.6e-11 43.0 0.3 5.3e-11 42.0 0.3 1.6 1 0 0 1 1 1 1 SAP domain zf-Nse PF11789.8 EDO14512.1 - 3e-06 26.9 0.8 6.3e-06 25.9 0.8 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_UBOX PF13445.6 EDO14512.1 - 0.0032 17.5 2.3 0.0069 16.4 2.3 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 EDO14512.1 - 0.43 10.8 3.5 0.8 9.9 3.5 1.5 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.6 EDO14512.1 - 0.83 10.0 3.8 1.6 9.1 3.8 1.5 1 0 0 1 1 1 0 Ring finger domain zf-C3HC4_2 PF13923.6 EDO14512.1 - 0.97 9.3 5.6 1.6 8.6 4.4 1.9 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Cwf_Cwc_15 PF04889.12 EDO14512.1 - 1.2 8.9 9.9 2.3 7.9 9.9 1.4 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein zf-WRNIP1_ubi PF18279.1 EDO14512.1 - 1.3 9.8 4.1 16 6.4 0.9 2.6 2 0 0 2 2 2 0 Werner helicase-interacting protein 1 ubiquitin-binding domain MLVIN_C PF18697.1 EDO14513.1 - 0.0021 18.1 0.4 0.0032 17.5 0.4 1.3 1 0 0 1 1 1 1 Murine leukemia virus (MLV) integrase (IN) C-terminal domain Minor_capsid_2 PF11114.8 EDO14513.1 - 0.019 15.0 0.4 0.029 14.4 0.4 1.5 1 1 0 1 1 1 0 Minor capsid protein Aminotran_1_2 PF00155.21 EDO14514.1 - 1.1e-21 77.5 0.0 1.8e-21 76.8 0.0 1.3 1 1 0 1 1 1 1 Aminotransferase class I and II Phosphorylase PF00343.20 EDO14515.1 - 0 1035.7 0.0 0 1035.5 0.0 1.0 1 0 0 1 1 1 1 Carbohydrate phosphorylase MCM PF00493.23 EDO14516.1 - 1.1e-102 341.9 0.4 1.7e-102 341.3 0.4 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 EDO14516.1 - 2.9e-39 133.8 0.0 6.9e-39 132.6 0.0 1.7 1 0 0 1 1 1 1 MCM OB domain MCM6_C PF18263.1 EDO14516.1 - 2.7e-31 108.0 0.8 2.7e-31 108.0 0.8 2.3 2 0 0 2 2 2 1 MCM6 C-terminal winged-helix domain MCM_lid PF17855.1 EDO14516.1 - 1.4e-27 95.9 1.6 3.2e-27 94.8 1.6 1.7 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 EDO14516.1 - 5.1e-26 91.3 3.3 5.7e-26 91.1 0.9 2.3 2 0 0 2 2 2 1 MCM N-terminal domain Mg_chelatase PF01078.21 EDO14516.1 - 1e-06 28.3 0.0 4.4e-06 26.2 0.0 2.0 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.26 EDO14516.1 - 0.0077 15.9 0.0 0.015 15.0 0.0 1.4 1 0 0 1 1 1 1 Sigma-54 interaction domain GIDA_assoc PF13932.6 EDO14516.1 - 0.0084 16.3 0.8 0.052 13.7 0.0 2.4 2 0 0 2 2 2 1 GidA associated domain AAA_3 PF07726.11 EDO14516.1 - 0.0085 15.9 0.0 0.02 14.8 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) C1q PF00386.21 EDO14516.1 - 0.045 14.0 0.2 0.1 12.8 0.2 1.5 1 0 0 1 1 1 0 C1q domain AAA_5 PF07728.14 EDO14516.1 - 0.1 12.6 0.0 0.24 11.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) F_bP_aldolase PF01116.20 EDO14517.1 - 3.2e-90 302.4 0.0 3.6e-90 302.2 0.0 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-II SNAP PF14938.6 EDO14517.1 - 0.044 13.2 0.1 0.074 12.5 0.1 1.2 1 0 0 1 1 1 0 Soluble NSF attachment protein, SNAP eIF-6 PF01912.18 EDO14518.1 - 3e-81 271.6 0.3 3.7e-81 271.2 0.3 1.1 1 0 0 1 1 1 1 eIF-6 family Mss4 PF04421.13 EDO14519.1 - 7.2e-20 70.9 0.4 1e-19 70.5 0.4 1.1 1 0 0 1 1 1 1 Mss4 protein SIKE PF05769.11 EDO14520.1 - 0.004 17.1 3.2 0.011 15.6 3.2 1.8 1 0 0 1 1 1 1 SIKE family Phage_TAC_3 PF06896.11 EDO14520.1 - 9.7 6.8 17.6 1.7 9.2 1.0 3.6 3 1 0 3 3 3 0 Phage tail assembly chaperone proteins, TAC CAF1A PF12253.8 EDO14521.1 - 1.5e-22 79.5 10.6 1.5e-22 79.5 10.6 4.7 2 1 1 3 3 3 1 Chromatin assembly factor 1 subunit A Na_trans_assoc PF06512.13 EDO14521.1 - 1 9.6 0.0 1 9.6 0.0 3.4 1 1 2 3 3 3 0 Sodium ion transport-associated MCM PF00493.23 EDO14522.1 - 2.9e-100 334.0 0.0 4.5e-100 333.4 0.0 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 EDO14522.1 - 3.6e-37 127.0 0.3 6.9e-37 126.1 0.3 1.5 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 EDO14522.1 - 3.7e-29 101.0 2.8 7.2e-29 100.0 2.0 2.0 2 0 0 2 2 2 1 MCM AAA-lid domain MCM_N PF14551.6 EDO14522.1 - 2.2e-16 60.3 5.0 8.7e-16 58.4 5.0 2.1 1 0 0 1 1 1 1 MCM N-terminal domain AAA_5 PF07728.14 EDO14522.1 - 2.3e-06 27.7 0.0 2.5e-05 24.3 0.0 2.6 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 EDO14522.1 - 7.2e-06 25.5 0.0 0.00015 21.2 0.0 2.5 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 EDO14522.1 - 0.00059 19.7 0.0 0.0056 16.5 0.0 2.3 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) GGA_N-GAT PF18308.1 EDO14522.1 - 0.0063 16.1 0.1 0.021 14.4 0.1 1.9 1 0 0 1 1 1 1 GGA N-GAT domain DUF3465 PF11948.8 EDO14522.1 - 0.023 14.5 0.3 0.071 13.0 0.3 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3465) Latarcin PF10279.9 EDO14522.1 - 0.025 15.0 0.0 0.18 12.2 0.0 2.6 2 1 0 2 2 2 0 Latarcin precursor Sigma54_activat PF00158.26 EDO14522.1 - 0.067 12.9 0.2 5.9 6.6 0.0 3.2 3 0 0 3 3 3 0 Sigma-54 interaction domain ATP-synt_G PF04718.15 EDO14523.1 - 4.5e-32 110.9 1.2 5.3e-32 110.6 1.2 1.1 1 0 0 1 1 1 1 Mitochondrial ATP synthase g subunit DEAD PF00270.29 EDO14524.1 - 1.1e-44 152.3 0.9 4.3e-44 150.4 0.1 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDO14524.1 - 3.7e-31 107.7 4.7 7.4e-28 97.1 0.0 2.8 3 0 0 3 3 3 2 Helicase conserved C-terminal domain Nucleoporin_FG PF13634.6 EDO14525.1 - 4.1e-14 53.2 106.3 1.6e-08 35.3 36.4 4.8 2 1 2 4 4 4 3 Nucleoporin FG repeat region DUF1664 PF07889.12 EDO14525.1 - 0.57 10.2 6.2 21 5.2 2.0 3.1 2 1 2 4 4 4 0 Protein of unknown function (DUF1664) Pkinase PF00069.25 EDO14526.1 - 1e-66 225.0 0.0 2.2e-66 223.9 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO14526.1 - 7.6e-31 107.3 0.0 1.2e-30 106.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.24 EDO14526.1 - 2.5e-10 40.9 2.8 2.5e-10 40.9 2.8 2.3 2 0 0 2 2 2 1 Protein kinase C terminal domain C2 PF00168.30 EDO14526.1 - 7.4e-10 39.1 0.0 0.00012 22.3 0.0 2.7 2 0 0 2 2 2 2 C2 domain Kinase-like PF14531.6 EDO14526.1 - 4.4e-09 36.1 0.0 1.6e-08 34.3 0.0 1.8 2 0 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 EDO14526.1 - 0.0051 15.8 0.0 0.0051 15.8 0.0 2.6 3 1 0 3 3 3 1 Haspin like kinase domain YrbL-PhoP_reg PF10707.9 EDO14526.1 - 0.044 13.3 0.0 0.1 12.1 0.0 1.5 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL FTA2 PF13095.6 EDO14526.1 - 0.14 11.8 2.8 1.5 8.4 0.0 3.1 4 0 0 4 4 4 0 Kinetochore Sim4 complex subunit FTA2 HSF_DNA-bind PF00447.17 EDO14527.1 - 1.6e-30 105.6 1.2 4.2e-30 104.2 1.2 1.8 1 0 0 1 1 1 1 HSF-type DNA-binding Response_reg PF00072.24 EDO14527.1 - 1.3e-27 96.2 0.5 5.3e-27 94.2 0.2 2.2 2 0 0 2 2 2 1 Response regulator receiver domain Rab5-bind PF09311.11 EDO14527.1 - 0.00093 18.7 6.3 0.0022 17.4 6.3 1.6 1 0 0 1 1 1 1 Rabaptin-like protein bZIP_1 PF00170.21 EDO14527.1 - 0.016 15.3 3.2 0.055 13.6 3.2 1.9 1 0 0 1 1 1 0 bZIP transcription factor TFR_dimer PF04253.15 EDO14527.1 - 0.032 14.3 0.5 0.087 12.9 0.5 1.7 1 0 0 1 1 1 0 Transferrin receptor-like dimerisation domain CCDC92 PF14916.6 EDO14527.1 - 0.036 13.8 0.9 0.095 12.5 0.9 1.7 1 0 0 1 1 1 0 Coiled-coil domain of unknown function HALZ PF02183.18 EDO14527.1 - 0.04 14.2 5.4 0.15 12.3 5.4 2.0 1 0 0 1 1 1 0 Homeobox associated leucine zipper DivIC PF04977.15 EDO14527.1 - 0.24 11.2 6.5 0.042 13.6 2.1 2.0 2 0 0 2 2 2 0 Septum formation initiator 5-FTHF_cyc-lig PF01812.20 EDO14528.1 - 8.5e-43 146.4 0.0 9.9e-43 146.2 0.0 1.0 1 0 0 1 1 1 1 5-formyltetrahydrofolate cyclo-ligase family IL3 PF02059.15 EDO14528.1 - 0.077 13.1 0.8 1.6 8.8 0.1 2.2 1 1 1 2 2 2 0 Interleukin-3 Aminotran_4 PF01063.19 EDO14529.1 - 3.2e-34 118.7 0.0 3.9e-34 118.4 0.0 1.1 1 0 0 1 1 1 1 Amino-transferase class IV RVT_2 PF07727.14 EDO14531.1 - 3.8e-54 183.9 0.0 4.9e-54 183.5 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Ribosomal_S26e PF01283.19 EDO14532.1 - 1.2e-50 170.4 10.7 1.4e-50 170.2 10.7 1.0 1 0 0 1 1 1 1 Ribosomal protein S26e WD40 PF00400.32 EDO14533.1 - 1.2e-15 57.6 2.4 0.0028 18.4 0.1 6.8 6 0 0 6 6 6 5 WD domain, G-beta repeat COX6A PF02046.15 EDO14534.1 - 3.8e-40 136.8 1.1 4.3e-40 136.7 1.1 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIa MT-A70 PF05063.14 EDO14535.1 - 4.2e-57 192.8 0.2 7.2e-57 192.0 0.2 1.4 1 0 0 1 1 1 1 MT-A70 Serglycin PF04360.12 EDO14535.1 - 0.0033 17.4 3.5 0.0072 16.3 3.5 1.6 1 0 0 1 1 1 1 Serglycin Glyco_hydro_30 PF02055.16 EDO14535.1 - 0.04 12.9 0.0 0.077 12.0 0.0 1.4 1 0 0 1 1 1 0 Glycosyl hydrolase family 30 TIM-barrel domain POX PF07526.11 EDO14535.1 - 8.4 7.0 9.2 2.4 8.7 2.1 2.6 2 0 0 2 2 2 0 Associated with HOX Hist_deacetyl PF00850.19 EDO14536.1 - 4.8e-84 282.4 0.0 6.8e-84 281.9 0.0 1.2 1 0 0 1 1 1 1 Histone deacetylase domain U1snRNP70_N PF12220.8 EDO14538.1 - 1.5e-20 73.6 1.3 1.5e-20 73.6 1.3 3.0 2 1 0 2 2 2 1 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal RRM_1 PF00076.22 EDO14538.1 - 2.9e-14 52.6 0.2 8.6e-14 51.1 0.2 1.8 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EDO14538.1 - 6.1e-08 32.7 0.1 2e-07 31.0 0.0 1.8 2 0 0 2 2 2 1 RNA recognition motif NAT PF04768.13 EDO14539.1 - 4.3e-53 179.5 0.7 4.3e-53 179.5 0.7 2.0 2 0 0 2 2 2 1 NAT, N-acetyltransferase, of N-acetylglutamate synthase Semialdhyde_dh PF01118.24 EDO14539.1 - 2.5e-30 105.4 0.0 6.5e-30 104.1 0.0 1.8 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain AA_kinase PF00696.28 EDO14539.1 - 1.3e-26 93.7 0.1 3.7e-26 92.2 0.1 1.7 1 0 0 1 1 1 1 Amino acid kinase family Semialdhyde_dhC PF02774.18 EDO14539.1 - 3.9e-09 36.8 0.0 1.6e-08 34.9 0.0 2.1 1 1 0 1 1 1 1 Semialdehyde dehydrogenase, dimerisation domain DapB_N PF01113.20 EDO14539.1 - 0.037 14.1 0.0 0.15 12.2 0.0 2.1 2 0 0 2 2 2 0 Dihydrodipicolinate reductase, N-terminus Ran_BP1 PF00638.18 EDO14540.1 - 2e-35 121.7 0.1 4.7e-35 120.5 0.1 1.6 1 0 0 1 1 1 1 RanBP1 domain DUF572 PF04502.13 EDO14540.1 - 1.4 8.5 20.8 2.1 7.9 20.8 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF572) Fis1_TPR_C PF14853.6 EDO14541.1 - 1.4e-20 73.1 0.4 2.6e-20 72.2 0.4 1.5 1 0 0 1 1 1 1 Fis1 C-terminal tetratricopeptide repeat Fis1_TPR_N PF14852.6 EDO14541.1 - 2.7e-15 55.7 0.1 4.4e-15 55.0 0.1 1.4 1 0 0 1 1 1 1 Fis1 N-terminal tetratricopeptide repeat Ribonuc_red_lgC PF02867.15 EDO14542.1 - 4.1e-185 616.3 0.0 5.3e-185 615.9 0.0 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, barrel domain Ribonuc_red_lgN PF00317.21 EDO14542.1 - 5.2e-25 87.3 0.0 1.9e-24 85.4 0.0 2.0 1 0 0 1 1 1 1 Ribonucleotide reductase, all-alpha domain ATP-cone PF03477.16 EDO14542.1 - 7e-17 61.8 0.1 2.9e-16 59.8 0.0 2.2 2 0 0 2 2 2 1 ATP cone domain Sec6 PF06046.13 EDO14543.1 - 1.7e-37 129.1 2.5 1.7e-37 129.1 2.5 1.7 2 0 0 2 2 2 1 Exocyst complex component Sec6 DUF948 PF06103.11 EDO14543.1 - 0.11 12.8 4.5 2.3 8.5 0.1 3.0 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF948) FokI_C PF02980.16 EDO14543.1 - 0.18 11.8 1.6 0.52 10.3 0.7 2.1 2 0 0 2 2 2 0 Restriction endonuclease FokI, catalytic domain DUF1788 PF08747.11 EDO14543.1 - 5.3 7.1 7.9 1.8 8.6 0.9 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF1788) UPF0449 PF15136.6 EDO14543.1 - 9.7 6.7 7.4 75 3.9 0.1 2.6 2 0 0 2 2 2 0 Uncharacterised protein family UPF0449 OmpH PF03938.14 EDO14544.1 - 0.42 11.0 25.9 0.66 10.3 11.4 2.2 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) Integrase_H2C2 PF17921.1 EDO14545.1 - 0.45 10.7 4.6 2.1 8.5 4.2 2.0 2 0 0 2 2 2 0 Integrase zinc binding domain RVT_1 PF00078.27 EDO14546.1 - 3.3e-16 59.5 0.2 4.1e-13 49.3 0.0 2.6 2 0 0 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_2 PF07727.14 EDO14546.1 - 0.043 13.4 0.3 0.39 10.3 0.3 2.1 1 1 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) Retrotrans_gag PF03732.17 EDO14548.1 - 3.9e-06 27.1 0.0 1.7e-05 25.0 0.0 2.0 2 0 0 2 2 2 1 Retrotransposon gag protein Op_neuropeptide PF08035.11 EDO14548.1 - 0.14 12.0 0.2 0.24 11.3 0.2 1.4 1 0 0 1 1 1 0 Opioids neuropeptide Phage_RpbA PF10789.9 EDO14549.1 - 0.06 13.4 0.7 1.5 8.9 0.0 3.0 3 0 0 3 3 3 0 Phage RNA polymerase binding, RpbA Cas6b_C PF17262.2 EDO14549.1 - 0.54 10.4 7.3 1.5 8.9 0.6 3.8 3 1 2 5 5 5 0 Cas6b C-terminal domain DUF592 PF04574.13 EDO14549.1 - 2.7 7.7 10.1 0.44 10.3 4.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF592) XPG_N PF00752.17 EDO14550.1 - 8.7e-35 119.2 0.0 2.3e-34 117.9 0.0 1.8 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.18 EDO14550.1 - 9.7e-27 93.2 0.0 7.1e-26 90.4 0.0 2.7 1 0 0 1 1 1 1 XPG I-region 5_3_exonuc PF01367.20 EDO14550.1 - 0.0018 18.9 0.0 0.015 15.9 0.0 2.7 1 0 0 1 1 1 1 5'-3' exonuclease, C-terminal SAM fold RT_RNaseH_2 PF17919.1 EDO14551.1 - 3e-19 68.9 1.8 1.2e-18 67.0 0.1 2.8 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 EDO14551.1 - 5.7e-19 68.3 0.0 3.4e-18 65.8 0.0 2.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 EDO14551.1 - 8.2e-17 61.5 0.1 1.5e-15 57.3 0.1 2.5 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 EDO14551.1 - 9.1e-14 51.7 0.0 4e-13 49.6 0.0 2.1 1 0 0 1 1 1 1 Integrase core domain MLVIN_C PF18697.1 EDO14551.1 - 0.00025 21.1 0.5 0.0051 16.9 0.1 3.0 3 0 0 3 3 3 1 Murine leukemia virus (MLV) integrase (IN) C-terminal domain RVT_3 PF13456.6 EDO14551.1 - 0.15 11.9 0.0 0.42 10.4 0.0 1.8 1 0 0 1 1 1 0 Reverse transcriptase-like DUF2577 PF10844.8 EDO14551.1 - 0.17 12.1 1.3 2.1 8.6 0.2 3.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2577) Mannosyl_trans3 PF11051.8 EDO14552.1 - 2.2e-79 266.7 1.1 3.3e-79 266.1 1.1 1.3 1 0 0 1 1 1 1 Mannosyltransferase putative Glyco_transf_8 PF01501.20 EDO14552.1 - 0.00067 19.3 5.1 0.04 13.5 2.3 2.6 2 1 0 2 2 2 2 Glycosyl transferase family 8 FNIP_M PF14637.6 EDO14553.1 - 0.018 15.1 0.3 0.025 14.6 0.3 1.2 1 0 0 1 1 1 0 Folliculin-interacting protein middle domain Pneumo_M2 PF07380.11 EDO14553.1 - 0.071 13.4 1.7 0.17 12.2 0.2 2.1 2 0 0 2 2 2 0 Pneumovirus M2 protein Catalase PF00199.19 EDO14554.1 - 2.5e-167 556.8 0.6 3.3e-167 556.4 0.6 1.2 1 0 0 1 1 1 1 Catalase Catalase-rel PF06628.12 EDO14554.1 - 5.2e-10 39.4 0.0 2.5e-09 37.2 0.0 2.2 2 0 0 2 2 2 1 Catalase-related immune-responsive Gly_acyl_tr_C PF08444.10 EDO14554.1 - 0.14 12.4 0.1 0.88 9.9 0.0 2.4 3 0 0 3 3 3 0 Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region RPN7 PF10602.9 EDO14555.1 - 6.4e-54 182.3 3.3 6.4e-54 182.3 3.3 1.5 2 0 0 2 2 2 1 26S proteasome subunit RPN7 PCI PF01399.27 EDO14555.1 - 6.8e-17 61.9 0.1 1.9e-16 60.5 0.1 1.8 1 0 0 1 1 1 1 PCI domain CSN8_PSD8_EIF3K PF10075.9 EDO14555.1 - 0.00012 22.1 0.3 0.00086 19.3 0.1 2.2 2 0 0 2 2 2 1 CSN8/PSMD8/EIF3K family TPR_8 PF13181.6 EDO14555.1 - 0.0062 16.7 2.6 0.0091 16.1 0.8 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.6 EDO14555.1 - 0.0083 16.1 0.5 3.4 7.9 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 EDO14555.1 - 0.012 15.7 4.0 0.34 11.1 0.5 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF357 PF04010.13 EDO14555.1 - 0.013 15.6 0.2 0.037 14.1 0.2 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF357) TPR_12 PF13424.6 EDO14555.1 - 0.018 15.4 0.3 0.42 10.9 0.1 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 EDO14555.1 - 0.04 14.7 0.1 4.7 8.3 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_17 PF13431.6 EDO14555.1 - 0.078 13.4 0.7 0.27 11.7 0.1 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_10 PF13374.6 EDO14555.1 - 0.15 12.0 0.2 32 4.6 0.0 3.0 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.28 EDO14555.1 - 0.28 11.1 2.4 0.6 10.0 0.7 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat Pil1 PF13805.6 EDO14556.1 - 1.1e-123 411.9 0.1 1.4e-123 411.5 0.1 1.1 1 0 0 1 1 1 1 Eisosome component PIL1 COG4 PF08318.12 EDO14557.1 - 1.9e-88 296.8 7.4 4e-88 295.7 7.4 1.6 1 0 0 1 1 1 1 COG4 transport protein IF-2B PF01008.17 EDO14558.1 - 6.6e-93 311.0 0.4 6.6e-93 311.0 0.4 2.4 3 0 0 3 3 3 1 Initiation factor 2 subunit family DUF3626 PF12294.8 EDO14558.1 - 0.0042 16.2 0.3 0.26 10.3 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF3626) Androgen_recep PF02166.16 EDO14558.1 - 0.072 11.9 4.7 0.12 11.2 4.7 1.3 1 0 0 1 1 1 0 Androgen receptor Abi_2 PF07751.11 EDO14558.1 - 0.2 11.9 3.3 4.5 7.5 3.5 2.4 2 0 0 2 2 2 0 Abi-like protein Plasmodium_Vir PF05795.11 EDO14558.1 - 2.9 7.2 13.6 0.66 9.3 10.3 1.6 2 0 0 2 2 2 0 Plasmodium vivax Vir protein CLASP_N PF12348.8 EDO14559.1 - 1.3e-73 247.3 13.1 1.5e-71 240.6 7.5 2.4 2 0 0 2 2 2 2 CLASP N terminal GTP_cyclohydro2 PF00925.20 EDO14560.1 - 3.2e-56 189.4 0.0 4.3e-56 189.0 0.0 1.2 1 0 0 1 1 1 1 GTP cyclohydrolase II KH_1 PF00013.29 EDO14561.1 - 1.7e-28 98.2 16.1 4.7e-11 42.3 1.1 3.2 3 0 0 3 3 3 3 KH domain KH_2 PF07650.17 EDO14561.1 - 3.2e-06 26.9 12.0 0.016 15.0 1.6 3.6 3 1 0 3 3 3 3 KH domain KH_5 PF13184.6 EDO14561.1 - 0.0004 20.4 9.5 2 8.6 0.8 3.9 3 2 0 3 3 3 3 NusA-like KH domain KH_4 PF13083.6 EDO14561.1 - 0.0038 17.1 0.4 19 5.2 0.1 3.8 3 0 0 3 3 3 2 KH domain Mito_carr PF00153.27 EDO14562.1 - 1.8e-68 226.5 6.9 3.7e-24 84.5 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Fuseless PF15993.5 EDO14562.1 - 0.077 12.2 0.1 0.28 10.3 0.1 1.7 2 0 0 2 2 2 0 Fuseless TatD_DNase PF01026.21 EDO14564.1 - 3.4e-42 144.6 0.0 5.6e-42 143.9 0.0 1.3 1 1 0 1 1 1 1 TatD related DNase Cue1_U7BR PF18499.1 EDO14565.1 - 5.4e-24 84.0 3.6 9.6e-24 83.2 3.6 1.4 1 0 0 1 1 1 1 Ubc7p-binding region of Cue1 CUE PF02845.16 EDO14565.1 - 2.5e-09 36.7 0.0 4.5e-09 35.8 0.0 1.5 1 0 0 1 1 1 1 CUE domain DUF4834 PF16118.5 EDO14565.1 - 0.0027 18.6 0.8 0.0065 17.4 0.2 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4834) RLL PF10036.9 EDO14565.1 - 0.014 15.3 3.3 0.012 15.5 2.0 1.5 1 1 0 1 1 1 0 RNA transcription, translation and transport factor protein DUF2232 PF09991.9 EDO14565.1 - 0.19 10.9 0.0 0.27 10.4 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2232) Di19_C PF14571.6 EDO14565.1 - 0.38 11.3 3.9 0.69 10.5 0.5 2.3 2 0 0 2 2 2 0 Stress-induced protein Di19, C-terminal WD40 PF00400.32 EDO14566.1 - 8.2e-20 70.8 7.6 3.2e-05 24.6 0.1 6.4 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDO14566.1 - 1.1e-14 54.4 0.6 1.6e-06 28.4 0.1 5.3 3 2 4 7 7 7 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EDO14566.1 - 0.00022 21.2 0.7 0.038 13.9 0.0 3.3 2 1 1 3 3 3 1 Eukaryotic translation initiation factor eIF2A HPS3_N PF14761.6 EDO14566.1 - 0.0045 16.5 0.0 0.21 11.1 0.0 2.7 2 0 0 2 2 2 1 Hermansky-Pudlak syndrome 3 YtkA PF13115.6 EDO14566.1 - 0.043 14.4 1.1 0.11 13.1 1.1 1.8 1 0 0 1 1 1 0 YtkA-like Ge1_WD40 PF16529.5 EDO14566.1 - 0.05 12.6 0.1 8.3 5.3 0.0 2.9 3 0 0 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein DUF3363 PF11843.8 EDO14566.1 - 0.055 12.4 0.0 0.084 11.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3363) WD40_like PF17005.5 EDO14566.1 - 0.084 12.2 2.1 1.4 8.2 0.0 3.0 3 0 0 3 3 3 0 WD40-like domain Sortilin-Vps10 PF15902.5 EDO14567.1 - 5.4e-201 668.2 29.2 3.4e-144 481.0 3.9 3.6 2 1 0 2 2 2 2 Sortilin, neurotensin receptor 3, Sortilin_C PF15901.5 EDO14567.1 - 1.2e-70 237.3 14.4 2.2e-40 138.8 1.8 2.7 2 0 0 2 2 2 2 Sortilin, neurotensin receptor 3, C-terminal BNR PF02012.20 EDO14567.1 - 3.7e-14 50.4 53.7 0.5 10.6 0.6 13.4 13 0 0 13 13 13 9 BNR/Asp-box repeat Mo-co_dimer PF03404.16 EDO14567.1 - 3e-05 24.0 0.4 1.2 9.2 0.0 4.7 5 0 0 5 5 5 2 Mo-co oxidoreductase dimerisation domain DUF2147 PF09917.9 EDO14567.1 - 0.015 15.9 0.2 0.16 12.6 0.0 2.7 2 1 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2147) CHB_HEX_C PF03174.13 EDO14567.1 - 0.039 13.9 4.7 22 5.1 0.1 5.0 5 0 0 5 5 5 0 Chitobiase/beta-hexosaminidase C-terminal domain BNR_6 PF15899.5 EDO14567.1 - 1.2 9.4 15.8 44 4.5 0.2 7.5 8 0 0 8 8 8 0 BNR-Asp box repeat SIR4_SID PF16991.5 EDO14568.1 - 6.2e-20 71.9 2.7 6.2e-20 71.9 2.7 4.3 3 2 2 5 5 5 1 Sir4 SID domain YkuI_C PF10388.9 EDO14568.1 - 0.02 14.7 3.7 0.022 14.6 1.2 2.3 2 0 0 2 2 2 0 EAL-domain associated signalling protein domain SlyX PF04102.12 EDO14569.1 - 0.002 18.7 1.8 0.8 10.4 0.1 3.6 2 1 0 2 2 2 2 SlyX DUF1664 PF07889.12 EDO14569.1 - 1.3 9.0 22.3 0.036 14.1 1.0 3.8 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) CFIA_Pcf11 PF11526.8 EDO14570.1 - 2.8e-29 101.4 2.8 2.8e-29 101.4 2.8 2.2 2 0 0 2 2 2 1 Subunit of cleavage factor IA Pcf11 VHS PF00790.19 EDO14570.1 - 0.0003 20.7 0.0 0.0018 18.1 0.0 2.3 2 0 0 2 2 2 1 VHS domain CTD_bind PF04818.13 EDO14570.1 - 0.011 16.5 0.6 0.066 14.0 0.1 2.7 3 0 0 3 3 2 0 RNA polymerase II-binding domain. Zn-C2H2_12 PF18112.1 EDO14570.1 - 0.035 14.6 3.7 6.7 7.3 0.0 3.5 3 0 0 3 3 3 0 Autophagy receptor zinc finger-C2H2 domain Cript PF10235.9 EDO14570.1 - 0.061 13.9 3.5 1.1 9.9 0.1 3.2 3 0 0 3 3 3 0 Microtubule-associated protein CRIPT zf-C2H2_4 PF13894.6 EDO14570.1 - 0.069 14.0 2.5 4.2 8.5 0.3 2.8 2 0 0 2 2 2 0 C2H2-type zinc finger EMC3_TMCO1 PF01956.16 EDO14570.1 - 0.095 12.4 2.8 0.21 11.3 2.8 1.5 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like zf-C2HE PF16278.5 EDO14570.1 - 0.15 12.5 1.6 0.38 11.2 0.0 2.6 2 0 0 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2 PF00096.26 EDO14570.1 - 0.6 10.7 2.4 21 5.8 0.3 2.7 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EDO14570.1 - 0.69 10.5 3.1 8 7.1 0.5 2.6 2 0 0 2 2 2 0 Zinc-finger double domain zf-C2H2_6 PF13912.6 EDO14570.1 - 2.2 8.4 4.0 5.5 7.1 0.5 2.5 2 0 0 2 2 2 0 C2H2-type zinc finger Vps39_2 PF10367.9 EDO14570.1 - 3.6 8.1 5.7 8.8 6.8 0.0 3.3 3 0 0 3 3 3 0 Vacuolar sorting protein 39 domain 2 Mito_carr PF00153.27 EDO14571.1 - 8e-34 115.5 0.9 4.9e-15 55.2 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Methyltransf_4 PF02390.17 EDO14572.1 - 8e-61 204.5 0.1 1.1e-60 204.0 0.1 1.2 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_25 PF13649.6 EDO14572.1 - 0.00014 22.5 0.0 0.0022 18.7 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EDO14572.1 - 0.0057 17.4 0.0 0.018 15.8 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EDO14572.1 - 0.0069 15.9 0.0 0.04 13.5 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_31 PF13847.6 EDO14572.1 - 0.0092 15.8 0.1 0.019 14.7 0.1 1.6 1 1 0 1 1 1 1 Methyltransferase domain Ribosomal_L10 PF00466.20 EDO14573.1 - 4.5e-08 33.2 0.1 7.8e-08 32.4 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L10 BRCT_2 PF16589.5 EDO14573.1 - 0.032 14.6 0.0 0.062 13.7 0.0 1.5 1 0 0 1 1 1 0 BRCT domain, a BRCA1 C-terminus domain DUF1507 PF07408.11 EDO14573.1 - 0.056 13.3 0.3 0.73 9.7 0.2 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF1507) Trm56 PF01994.16 EDO14573.1 - 0.084 12.8 0.0 0.16 11.9 0.0 1.5 1 0 0 1 1 1 0 tRNA ribose 2'-O-methyltransferase, aTrm56 Gam PF06064.11 EDO14574.1 - 0.01 16.1 1.3 0.039 14.2 0.3 2.3 2 0 0 2 2 2 0 Host-nuclease inhibitor protein Gam Sel1 PF08238.12 EDO14575.1 - 9.2e-18 64.3 13.4 5.3e-05 23.7 0.0 7.6 6 2 1 7 7 7 5 Sel1 repeat DUF1682 PF07946.14 EDO14576.1 - 2.4e-73 247.2 8.8 3.1e-73 246.8 8.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1682) Thr_synth_N PF14821.6 EDO14577.1 - 9.6e-28 96.2 0.1 3.4e-27 94.5 0.0 2.0 2 0 0 2 2 2 1 Threonine synthase N terminus PALP PF00291.25 EDO14577.1 - 5.4e-12 45.7 0.0 9.7e-12 44.9 0.0 1.3 1 1 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme NitrOD5 PF11537.8 EDO14577.1 - 0.038 14.1 0.0 0.083 13.0 0.0 1.6 1 0 0 1 1 1 0 Nitrosopumilus output domain 5 Ytp1 PF10355.9 EDO14578.1 - 7.2e-108 360.0 12.4 1.3e-107 359.2 12.4 1.4 1 0 0 1 1 1 1 Protein of unknown function (Ytp1) DUF2427 PF10348.9 EDO14578.1 - 1.9e-31 108.0 6.1 1.9e-31 108.0 6.1 3.2 3 1 1 4 4 4 2 Domain of unknown function (DUF2427) UPF1_Zn_bind PF09416.10 EDO14579.1 - 4.7e-65 218.2 8.1 1.4e-64 216.7 5.1 2.3 2 0 0 2 2 2 1 RNA helicase (UPF2 interacting domain) AAA_12 PF13087.6 EDO14579.1 - 7.6e-58 195.4 0.0 8e-57 192.1 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.6 EDO14579.1 - 9.9e-50 169.7 4.3 1.8e-26 93.5 0.9 2.5 1 1 1 2 2 2 2 AAA domain DUF5599 PF18141.1 EDO14579.1 - 1.1e-27 96.1 0.0 2.4e-27 95.0 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF5599) AAA_30 PF13604.6 EDO14579.1 - 6.1e-17 62.0 0.3 5.7e-16 58.8 0.3 2.1 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EDO14579.1 - 3.1e-13 50.3 0.1 6.3e-13 49.3 0.1 1.5 1 0 0 1 1 1 1 AAA domain DUF2075 PF09848.9 EDO14579.1 - 2e-05 24.0 0.1 0.0009 18.6 0.0 3.1 2 1 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) ResIII PF04851.15 EDO14579.1 - 2.1e-05 24.6 0.0 5.4e-05 23.3 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit UvrD-helicase PF00580.21 EDO14579.1 - 5.7e-05 22.8 1.9 0.0092 15.5 0.0 2.9 2 1 0 3 3 3 1 UvrD/REP helicase N-terminal domain Viral_helicase1 PF01443.18 EDO14579.1 - 0.00015 21.6 0.0 0.8 9.4 0.0 3.0 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase Helicase_RecD PF05127.14 EDO14579.1 - 0.0009 19.1 0.0 0.002 18.0 0.0 1.6 1 0 0 1 1 1 1 Helicase PhoH PF02562.16 EDO14579.1 - 0.006 16.1 0.0 0.012 15.0 0.0 1.4 1 0 0 1 1 1 1 PhoH-like protein DEAD PF00270.29 EDO14579.1 - 0.012 15.4 0.0 0.021 14.6 0.0 1.4 1 0 0 1 1 1 0 DEAD/DEAH box helicase PIF1 PF05970.14 EDO14579.1 - 0.013 14.7 0.0 4.6 6.3 0.0 2.3 2 0 0 2 2 2 0 PIF1-like helicase T2SSE PF00437.20 EDO14579.1 - 0.028 13.5 0.0 0.056 12.5 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein Flavi_DEAD PF07652.14 EDO14579.1 - 0.05 13.6 0.0 0.093 12.7 0.0 1.4 1 0 0 1 1 1 0 Flavivirus DEAD domain AAA_22 PF13401.6 EDO14579.1 - 0.051 13.8 0.0 0.13 12.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain HSP20 PF00011.21 EDO14579.1 - 0.084 13.0 0.0 0.3 11.3 0.0 1.9 1 0 0 1 1 1 0 Hsp20/alpha crystallin family DUF4088 PF13317.6 EDO14579.1 - 0.11 12.0 0.1 0.19 11.3 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4088) AAA_24 PF13479.6 EDO14579.1 - 0.14 11.9 0.0 0.26 11.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EDO14579.1 - 0.15 12.4 0.1 0.31 11.4 0.1 1.4 1 0 0 1 1 1 0 AAA ATPase domain HEM4 PF02602.15 EDO14579.1 - 0.17 11.2 0.1 0.3 10.4 0.1 1.3 1 0 0 1 1 1 0 Uroporphyrinogen-III synthase HemD SRP54 PF00448.22 EDO14579.1 - 0.19 11.3 0.0 0.32 10.6 0.0 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain Transp_Tc5_C PF04236.15 EDO14579.1 - 2.2 8.7 5.9 0.38 11.1 1.0 2.3 2 0 0 2 2 1 0 Tc5 transposase C-terminal domain GATase_5 PF13507.6 EDO14580.1 - 3.2e-98 328.0 0.0 4.7e-98 327.4 0.0 1.2 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain AIRS_C PF02769.22 EDO14580.1 - 3.3e-44 150.8 0.1 5.8e-30 104.5 0.0 2.3 2 0 0 2 2 2 2 AIR synthase related protein, C-terminal domain FGAR-AT_N PF18076.1 EDO14580.1 - 4e-24 84.8 0.0 7e-24 84.0 0.0 1.4 1 0 0 1 1 1 1 Formylglycinamide ribonucleotide amidotransferase N-terminal FGAR-AT_linker PF18072.1 EDO14580.1 - 5e-22 78.2 0.0 1.2e-21 76.9 0.0 1.7 1 0 0 1 1 1 1 Formylglycinamide ribonucleotide amidotransferase linker domain DUF2462 PF09495.10 EDO14581.1 - 2e-15 57.3 12.2 2e-15 57.3 12.2 1.4 2 0 0 2 2 2 1 Protein of unknown function (DUF2462) Glutaredoxin PF00462.24 EDO14582.1 - 8.5e-08 32.3 0.0 1.7e-07 31.4 0.0 1.5 1 1 0 1 1 1 1 Glutaredoxin Thioredoxin PF00085.20 EDO14582.1 - 6.7e-05 22.8 0.0 8.7e-05 22.5 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin DUF953 PF06110.11 EDO14582.1 - 0.0017 17.9 0.4 0.0025 17.4 0.4 1.4 1 1 0 1 1 1 1 Eukaryotic protein of unknown function (DUF953) Thioredoxin_9 PF14595.6 EDO14582.1 - 0.0027 17.5 0.0 0.0033 17.2 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 EDO14582.1 - 0.067 13.7 0.1 0.13 12.8 0.1 1.5 1 1 0 1 1 1 0 Thioredoxin-like domain MFS_1 PF07690.16 EDO14583.1 - 2.7e-21 75.9 22.5 3.1e-20 72.4 22.1 2.0 2 0 0 2 2 2 2 Major Facilitator Superfamily zf-C2H2_4 PF13894.6 EDO14584.1 - 1.8e-05 25.2 27.2 0.0039 17.9 1.8 4.9 5 0 0 5 5 4 3 C2H2-type zinc finger SR-25 PF10500.9 EDO14584.1 - 9e-05 22.2 27.2 0.0018 18.0 8.9 2.2 2 0 0 2 2 2 2 Nuclear RNA-splicing-associated protein zf-C2H2_6 PF13912.6 EDO14584.1 - 0.00082 19.3 13.2 0.00085 19.3 0.5 4.3 3 1 0 3 3 3 1 C2H2-type zinc finger Zn-C2H2_12 PF18112.1 EDO14584.1 - 0.0014 19.1 0.9 1.4 9.4 0.0 3.5 3 0 0 3 3 3 1 Autophagy receptor zinc finger-C2H2 domain zf-C2H2 PF00096.26 EDO14584.1 - 0.0024 18.2 3.4 0.0024 18.2 3.4 5.3 4 1 1 5 5 5 2 Zinc finger, C2H2 type IMUP PF15761.5 EDO14584.1 - 0.0073 17.0 19.6 0.14 12.8 6.0 2.6 2 0 0 2 2 2 2 Immortalisation up-regulated protein zf-Di19 PF05605.12 EDO14584.1 - 0.07 13.4 10.8 0.18 12.1 6.0 3.5 3 1 1 4 4 4 0 Drought induced 19 protein (Di19), zinc-binding zinc_ribbon_9 PF14369.6 EDO14584.1 - 0.21 11.9 4.9 0.9 9.9 0.3 3.3 3 0 0 3 3 3 0 zinc-ribbon zf-C3HC4_3 PF13920.6 EDO14584.1 - 0.31 10.9 6.3 6.1 6.8 0.4 3.2 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) zf-SNAP50_C PF12251.8 EDO14584.1 - 0.37 10.4 10.0 0.32 10.7 2.6 2.4 1 1 1 2 2 2 0 snRNA-activating protein of 50kDa MW C terminal Rad50_zn_hook PF04423.14 EDO14584.1 - 0.74 9.7 4.9 25 4.8 0.8 3.4 3 0 0 3 3 3 0 Rad50 zinc hook motif zf-C2H2_jaz PF12171.8 EDO14584.1 - 0.94 9.8 11.7 1.7 9.1 0.2 3.6 4 0 0 4 4 3 0 Zinc-finger double-stranded RNA-binding zf-RING_5 PF14634.6 EDO14584.1 - 1.8 8.6 8.7 25 5.0 0.6 3.4 3 0 0 3 3 3 0 zinc-RING finger domain Chorion_2 PF03964.15 EDO14584.1 - 2.4 9.0 10.5 0.42 11.5 0.5 2.4 2 0 0 2 2 2 0 Chorion family 2 Prok-RING_1 PF14446.6 EDO14584.1 - 2.5 8.1 9.4 5.3 7.1 0.0 3.7 3 1 0 3 3 3 0 Prokaryotic RING finger family 1 CTU2 PF10288.9 EDO14584.1 - 2.6 8.3 13.2 3.4 7.9 9.9 2.8 2 1 0 2 2 2 0 Cytoplasmic tRNA 2-thiolation protein 2 Flocculin PF00624.18 EDO14585.1 - 5.9e-63 208.8 294.1 6.5e-14 51.9 14.0 120.5 29 1 92 121 121 121 21 Flocculin repeat DUF723 PF05265.13 EDO14585.1 - 0.0059 16.5 0.1 27 4.8 0.0 3.8 3 0 0 3 3 3 1 Protein of unknown function (DUF723) YukC PF10140.9 EDO14585.1 - 0.052 12.4 0.7 0.1 11.4 0.7 1.3 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukC SUR7 PF06687.12 EDO14586.1 - 5.9e-20 71.8 21.4 1.1e-19 70.9 21.4 1.4 1 0 0 1 1 1 1 SUR7/PalI family FA_desaturase PF00487.24 EDO14586.1 - 1.6 8.5 4.7 0.2 11.5 0.6 1.6 2 0 0 2 2 2 0 Fatty acid desaturase DUF2070 PF09843.9 EDO14586.1 - 2.3 6.4 8.9 3.9 5.7 8.9 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) SNARE PF05739.19 EDO14587.1 - 1.1e-15 57.3 0.2 3.2e-15 55.8 0.2 1.9 1 0 0 1 1 1 1 SNARE domain WHIM1 PF15612.6 EDO14588.1 - 1.5e-06 27.6 0.0 4.6e-06 26.0 0.0 1.9 1 0 0 1 1 1 1 WSTF, HB1, Itc1p, MBD9 motif 1 Glycogen_syn PF05693.13 EDO14589.1 - 0 1104.2 0.0 0 1104.0 0.0 1.0 1 0 0 1 1 1 1 Glycogen synthase Glycos_transf_1 PF00534.20 EDO14589.1 - 9.2e-09 35.1 0.0 7.6e-06 25.6 0.0 2.4 2 0 0 2 2 2 2 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 EDO14589.1 - 6.1e-07 29.9 0.0 0.0013 19.1 0.0 2.5 2 0 0 2 2 2 2 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 EDO14589.1 - 1.7e-06 28.1 0.3 4e-06 26.9 0.3 1.6 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_transf_5 PF08323.11 EDO14589.1 - 2.8e-05 23.9 0.4 6.7e-05 22.7 0.4 1.7 1 1 0 1 1 1 1 Starch synthase catalytic domain Glyco_trans_4_4 PF13579.6 EDO14589.1 - 0.00052 20.5 0.0 0.0013 19.2 0.0 1.7 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain HTH_AraC PF00165.23 EDO14590.1 - 0.0023 18.0 0.0 0.006 16.7 0.0 1.7 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix proteins, AraC family HTH_18 PF12833.7 EDO14590.1 - 0.046 14.0 0.0 0.14 12.5 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain Methyltransf_12 PF08242.12 EDO14590.1 - 2 9.2 4.4 1.5 9.6 0.0 3.1 3 0 0 3 3 3 0 Methyltransferase domain MLVIN_C PF18697.1 EDO14591.1 - 0.00011 22.2 0.3 0.00027 21.0 0.3 1.8 1 1 0 1 1 1 1 Murine leukemia virus (MLV) integrase (IN) C-terminal domain IFRD_C PF04836.12 EDO14591.1 - 0.078 13.6 0.1 0.2 12.3 0.1 1.7 1 0 0 1 1 1 0 Interferon-related protein conserved region GST_C PF00043.25 EDO14592.1 - 1.3e-09 38.1 0.0 2.7e-09 37.1 0.0 1.5 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EDO14592.1 - 3.1e-05 23.9 0.0 7e-05 22.8 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EDO14592.1 - 0.0002 21.5 0.0 0.00097 19.3 0.0 2.1 2 1 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EDO14592.1 - 0.0012 19.1 0.0 0.003 17.8 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain RRM_1 PF00076.22 EDO14593.1 - 0.00012 21.8 0.0 0.044 13.6 0.0 2.8 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Flocculin PF00624.18 EDO14594.1 - 5.1e-30 103.4 156.1 1.5e-09 38.0 14.6 9.3 8 0 0 8 8 8 7 Flocculin repeat Topoisom_I_N PF02919.15 EDO14595.1 - 0.32 10.5 19.6 1.1e+02 2.2 0.0 17.2 23 1 1 24 24 24 0 Eukaryotic DNA topoisomerase I, DNA binding fragment BOP1NT PF08145.12 EDO14596.1 - 1.4e-103 346.4 6.8 2e-103 345.9 6.8 1.2 1 0 0 1 1 1 1 BOP1NT (NUC169) domain WD40 PF00400.32 EDO14596.1 - 8.7e-24 83.4 8.3 6.8e-10 39.4 0.4 6.8 6 1 1 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDO14596.1 - 7.3e-07 29.4 1.1 0.02 15.1 0.0 4.9 4 2 2 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain Nop53 PF07767.11 EDO14596.1 - 0.0059 16.0 2.5 0.019 14.4 2.5 1.8 1 1 0 1 1 1 1 Nop53 (60S ribosomal biogenesis) Nup160 PF11715.8 EDO14596.1 - 0.037 12.7 0.0 0.097 11.3 0.0 1.6 2 0 0 2 2 2 0 Nucleoporin Nup120/160 Nucleoporin_FG PF13634.6 EDO14597.1 - 1.1e-40 138.3 338.4 6.5e-09 36.5 33.6 11.0 2 2 10 12 12 12 11 Nucleoporin FG repeat region Nucleoporin2 PF04096.14 EDO14597.1 - 9.7e-34 116.6 0.0 1.8e-33 115.8 0.0 1.4 1 0 0 1 1 1 1 Nucleoporin autopeptidase SRF-TF PF00319.18 EDO14598.1 - 3.2e-21 74.6 0.2 4.7e-21 74.0 0.2 1.3 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) FAM220 PF15487.6 EDO14598.1 - 0.096 12.3 5.4 0.15 11.7 5.4 1.3 1 0 0 1 1 1 0 FAM220 family PepSY_TM PF03929.16 EDO14598.1 - 0.34 10.5 5.6 0.39 10.4 4.7 1.4 1 1 0 1 1 1 0 PepSY-associated TM region Presenilin PF01080.17 EDO14598.1 - 0.81 8.4 9.8 0.89 8.2 9.8 1.4 1 0 0 1 1 1 0 Presenilin PTPRCAP PF15713.5 EDO14598.1 - 4.6 7.5 15.7 8.5 6.7 15.7 1.4 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated CobT PF06213.12 EDO14598.1 - 6.3 6.1 21.3 9.5 5.5 21.3 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Bap31 PF05529.12 EDO14599.1 - 7.5e-24 84.1 4.6 9.7e-24 83.8 4.6 1.1 1 0 0 1 1 1 1 Bap31/Bap29 transmembrane region Bap31_Bap29_C PF18035.1 EDO14599.1 - 0.0024 17.9 5.8 0.0024 17.9 5.8 1.8 2 0 0 2 2 2 1 Bap31/Bap29 cytoplasmic coiled-coil domain YkyA PF10368.9 EDO14599.1 - 0.0069 16.1 1.4 0.0095 15.6 1.4 1.2 1 0 0 1 1 1 1 Putative cell-wall binding lipoprotein DUF4446 PF14584.6 EDO14599.1 - 0.01 15.9 0.2 0.018 15.1 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) Csm1_N PF18504.1 EDO14599.1 - 0.011 16.0 1.5 0.019 15.3 1.5 1.4 1 0 0 1 1 1 0 Csm1 N-terminal domain Pox_A30L_A26L PF06086.12 EDO14599.1 - 0.017 14.8 0.4 0.027 14.2 0.4 1.4 1 0 0 1 1 1 0 Orthopoxvirus A26L/A30L protein Anoctamin PF04547.12 EDO14599.1 - 0.02 13.7 0.2 0.022 13.6 0.2 1.1 1 0 0 1 1 1 0 Calcium-activated chloride channel CcmF_C PF16327.5 EDO14599.1 - 0.059 12.6 0.1 0.08 12.2 0.1 1.1 1 0 0 1 1 1 0 Cytochrome c-type biogenesis protein CcmF C-terminal LapA_dom PF06305.11 EDO14599.1 - 6.3 6.7 9.2 7.8 6.4 0.7 3.4 3 1 0 3 3 3 0 Lipopolysaccharide assembly protein A domain TssO PF17561.2 EDO14599.1 - 8 6.6 12.2 11 6.1 1.2 2.6 2 1 0 2 2 2 0 Type VI secretion system, TssO PC4 PF02229.16 EDO14600.1 - 1.2e-21 76.1 0.1 2e-21 75.4 0.1 1.4 1 0 0 1 1 1 1 Transcriptional Coactivator p15 (PC4) SPX PF03105.19 EDO14600.1 - 0.17 11.7 16.2 0.22 11.4 16.2 1.1 1 0 0 1 1 1 0 SPX domain CorA PF01544.18 EDO14601.1 - 6.3e-38 130.7 7.1 1.4e-20 73.9 0.1 4.0 3 1 1 4 4 4 3 CorA-like Mg2+ transporter protein CdiI_2 PF18593.1 EDO14601.1 - 0.027 15.1 1.2 2.8 8.7 0.3 2.9 2 0 0 2 2 2 0 CdiI immunity protein HMA PF00403.26 EDO14602.1 - 6.9e-13 48.8 0.1 1.3e-12 48.0 0.1 1.4 1 0 0 1 1 1 1 Heavy-metal-associated domain Sod_Cu PF00080.20 EDO14602.1 - 2.7e-06 27.6 0.0 6.1e-06 26.5 0.0 1.5 1 1 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) MAP65_ASE1 PF03999.12 EDO14603.1 - 3.7e-120 402.4 54.2 5.2e-120 401.9 54.2 1.2 1 0 0 1 1 1 1 Microtubule associated protein (MAP65/ASE1 family) SGS PF05002.15 EDO14604.1 - 4.6e-31 106.8 1.4 4.6e-31 106.8 1.4 2.3 2 0 0 2 2 2 1 SGS domain CS PF04969.16 EDO14604.1 - 2.7e-10 41.1 1.8 5.6e-10 40.1 1.8 1.6 1 0 0 1 1 1 1 CS domain TPR_2 PF07719.17 EDO14604.1 - 1.8 8.9 6.5 13 6.1 0.2 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat Flavoprotein PF02441.19 EDO14605.1 - 1.3e-62 210.2 0.6 2.3e-62 209.4 0.6 1.4 1 0 0 1 1 1 1 Flavoprotein Na_trans_assoc PF06512.13 EDO14605.1 - 2.1e-07 31.4 0.0 9.6e-07 29.3 0.0 2.1 2 2 0 2 2 2 1 Sodium ion transport-associated PPP4R2 PF09184.11 EDO14605.1 - 0.0066 16.1 27.5 0.0066 16.1 27.5 3.1 2 1 0 2 2 2 1 PPP4R2 MTA_R1 PF17226.2 EDO14605.1 - 0.18 11.9 0.0 0.57 10.4 0.0 1.8 1 0 0 1 1 1 0 MTA R1 domain RNA_pol_Rpc4 PF05132.14 EDO14605.1 - 0.24 11.8 4.5 0.32 11.4 2.9 2.2 2 0 0 2 2 2 0 RNA polymerase III RPC4 Nop14 PF04147.12 EDO14605.1 - 3.5 5.7 44.0 6.5 4.8 44.0 1.3 1 0 0 1 1 1 0 Nop14-like family SDA1 PF05285.12 EDO14605.1 - 5.7 6.3 44.8 11 5.4 44.8 1.4 1 0 0 1 1 1 0 SDA1 DUF4746 PF15928.5 EDO14605.1 - 8 5.8 17.5 2.1 7.7 13.9 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) CIAPIN1 PF05093.13 EDO14606.1 - 9.1e-39 132.0 3.4 2.5e-38 130.6 3.4 1.8 1 0 0 1 1 1 1 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis DRE2_N PF16803.5 EDO14606.1 - 1.1e-30 106.6 0.1 2.1e-30 105.6 0.1 1.5 1 0 0 1 1 1 1 Fe-S cluster assembly protein DRE2 N-terminus zf-CSL PF05207.13 EDO14606.1 - 0.44 10.3 5.7 3.9 7.3 5.7 2.4 1 1 0 1 1 1 0 CSL zinc finger zf-AN1 PF01428.16 EDO14607.1 - 1.1e-09 38.3 8.2 1.9e-09 37.5 8.2 1.4 1 0 0 1 1 1 1 AN1-like Zinc finger Transp_Tc5_C PF04236.15 EDO14607.1 - 0.13 12.7 6.5 0.23 11.8 6.5 1.4 1 0 0 1 1 1 0 Tc5 transposase C-terminal domain Ank_4 PF13637.6 EDO14608.1 - 9.4e-16 58.0 0.6 4.4e-12 46.3 0.0 2.6 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 EDO14608.1 - 1.1e-12 48.3 0.1 3.5e-12 46.8 0.1 1.9 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EDO14608.1 - 2.1e-12 47.0 0.0 5e-09 36.2 0.0 2.9 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 EDO14608.1 - 8.5e-12 45.0 1.0 3.1e-05 24.2 0.0 3.7 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.6 EDO14608.1 - 6.5e-11 41.5 0.1 2.2e-05 24.5 0.0 2.9 2 0 0 2 2 2 2 Ankyrin repeat TIG PF01833.24 EDO14608.1 - 8.2e-08 32.2 1.9 2.7e-07 30.6 1.9 1.9 1 0 0 1 1 1 1 IPT/TIG domain Macoilin PF09726.9 EDO14608.1 - 4.9 5.6 28.1 0.39 9.2 21.2 2.2 2 0 0 2 2 2 0 Macoilin family Flocculin PF00624.18 EDO14611.1 - 2.6e-16 59.6 61.5 8.3e-13 48.4 29.0 7.3 8 1 1 9 9 9 4 Flocculin repeat MetallophosN PF16371.5 EDO14611.1 - 0.13 12.6 2.6 13 6.2 0.1 3.6 4 0 0 4 4 4 0 N terminal of Calcineurin-like phosphoesterase SKG6 PF08693.10 EDO14612.1 - 4.5e-06 26.0 2.0 8.5e-06 25.1 2.0 1.5 1 0 0 1 1 1 1 Transmembrane alpha-helix domain TMEM51 PF15345.6 EDO14612.1 - 0.0058 16.5 0.0 0.014 15.3 0.0 1.6 1 0 0 1 1 1 1 Transmembrane protein 51 bMG6 PF17962.1 EDO14612.1 - 0.097 12.8 0.2 0.2 11.8 0.2 1.5 1 0 0 1 1 1 0 Bacterial macroglobulin domain 6 Myb_DNA-binding PF00249.31 EDO14613.1 - 2.7e-30 104.3 11.2 3.8e-12 46.2 0.1 3.8 3 0 0 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EDO14613.1 - 1.9e-29 101.7 6.7 8.5e-11 41.9 0.1 4.0 2 1 1 3 3 3 3 Myb-like DNA-binding domain SLIDE PF09111.10 EDO14613.1 - 3.7e-06 26.9 1.0 0.44 10.6 0.1 3.7 1 1 2 3 3 3 2 SLIDE Rap1_C PF11626.8 EDO14613.1 - 0.0035 17.4 0.7 1.4 9.1 0.1 3.1 2 1 1 3 3 3 2 TRF2-interacting telomeric protein/Rap1 - C terminal domain SANT_DAMP1_like PF16282.5 EDO14613.1 - 0.023 14.9 4.1 7.5 6.8 0.2 4.4 3 1 2 5 5 5 0 SANT/Myb-like domain of DAMP1 CSTF2_hinge PF14327.6 EDO14615.1 - 0.0013 19.2 4.9 0.056 13.9 0.1 3.9 4 0 0 4 4 4 2 Hinge domain of cleavage stimulation factor subunit 2 Pol_alpha_B_N PF08418.10 EDO14616.1 - 2.9e-67 227.2 4.1 3.9e-67 226.8 4.1 1.2 1 0 0 1 1 1 1 DNA polymerase alpha subunit B N-terminal DNA_pol_E_B PF04042.16 EDO14616.1 - 5.7e-49 166.3 1.4 5.7e-49 166.3 0.2 1.6 2 0 0 2 2 2 1 DNA polymerase alpha/epsilon subunit B DUF4125 PF13526.6 EDO14616.1 - 0.059 13.0 0.2 0.11 12.0 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4125) MP PF01107.18 EDO14616.1 - 0.13 11.8 1.0 0.34 10.5 0.7 1.8 2 0 0 2 2 2 0 Viral movement protein (MP) Anoctamin PF04547.12 EDO14617.1 - 2e-22 79.7 35.0 2.4e-21 76.1 34.9 2.5 1 1 0 1 1 1 1 Calcium-activated chloride channel Ala_racemase_N PF01168.20 EDO14618.1 - 6.2e-24 84.9 0.0 7.8e-24 84.5 0.0 1.1 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain DHQS PF01959.16 EDO14618.1 - 0.16 10.9 0.0 0.33 9.8 0.0 1.5 2 0 0 2 2 2 0 3-dehydroquinate synthase II DNA_pol3_delta2 PF13177.6 EDO14619.1 - 5e-11 42.7 0.2 3.6e-10 39.9 0.2 2.1 1 1 0 1 1 1 1 DNA polymerase III, delta subunit AAA PF00004.29 EDO14619.1 - 4.9e-09 36.7 0.1 1.9e-08 34.8 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta PF06144.13 EDO14619.1 - 0.0009 19.1 0.3 0.0009 19.1 0.3 2.1 3 0 0 3 3 3 1 DNA polymerase III, delta subunit AAA_16 PF13191.6 EDO14619.1 - 0.0014 19.0 0.0 0.0031 17.9 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain Rad17 PF03215.15 EDO14619.1 - 0.0022 17.9 0.0 0.0044 17.0 0.0 1.7 1 1 0 1 1 1 1 Rad17 P-loop domain Rep_fac_C PF08542.11 EDO14619.1 - 0.011 16.1 0.4 0.047 14.1 0.0 2.2 2 0 0 2 2 2 0 Replication factor C C-terminal domain AAA_22 PF13401.6 EDO14619.1 - 0.011 16.0 0.7 0.068 13.5 0.2 2.4 2 1 0 2 2 2 0 AAA domain HrcA_DNA-bdg PF03444.15 EDO14619.1 - 0.029 14.0 0.3 0.069 12.8 0.3 1.6 1 0 0 1 1 1 0 Winged helix-turn-helix transcription repressor, HrcA DNA-binding AAA_27 PF13514.6 EDO14619.1 - 0.14 11.7 0.0 0.28 10.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 EDO14619.1 - 0.15 11.8 0.2 0.65 9.7 0.2 1.9 1 1 0 1 1 1 0 AAA domain Ribosomal_L16 PF00252.18 EDO14620.1 - 5.4e-36 123.5 0.2 7e-36 123.1 0.2 1.2 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e tRNA-synt_2d PF01409.20 EDO14621.1 - 3.3e-46 157.8 0.9 6.8e-26 91.2 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) FDX-ACB PF03147.14 EDO14621.1 - 2e-27 95.4 0.1 1.1e-26 93.1 0.1 2.3 2 0 0 2 2 2 1 Ferredoxin-fold anticodon binding domain FAD_binding_1 PF00667.20 EDO14622.1 - 9.3e-26 90.8 0.0 2.1e-25 89.6 0.0 1.5 1 1 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 EDO14622.1 - 6e-20 71.9 0.0 2e-19 70.2 0.0 1.9 1 1 1 2 2 2 1 Flavodoxin NAD_binding_1 PF00175.21 EDO14622.1 - 1e-12 48.7 0.0 2.9e-12 47.2 0.0 1.8 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain PCNA_N PF00705.18 EDO14623.1 - 4.3e-54 181.6 1.8 4.7e-54 181.5 0.8 1.5 2 0 0 2 2 2 1 Proliferating cell nuclear antigen, N-terminal domain PCNA_C PF02747.15 EDO14623.1 - 6.8e-49 165.3 0.1 1.9e-48 163.8 0.0 1.7 2 0 0 2 2 2 1 Proliferating cell nuclear antigen, C-terminal domain Rad1 PF02144.16 EDO14623.1 - 4.5e-06 25.9 0.3 8.4e-05 21.8 0.3 2.0 1 1 0 1 1 1 1 Repair protein Rad1/Rec1/Rad17 Rad9 PF04139.13 EDO14623.1 - 0.00081 18.9 0.0 0.00093 18.7 0.0 1.1 1 0 0 1 1 1 1 Rad9 RRM_5 PF13893.6 EDO14624.1 - 1.3e-09 37.7 0.0 1.4e-09 37.6 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.22 EDO14624.1 - 1.8e-07 30.9 0.0 2.6e-07 30.3 0.0 1.3 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EDO14624.1 - 0.13 12.1 0.0 0.19 11.6 0.0 1.3 1 0 0 1 1 1 0 Occluded RNA-recognition motif HA2 PF04408.23 EDO14625.1 - 1.2e-22 80.3 0.1 5.9e-22 78.0 0.0 2.3 2 0 0 2 2 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 EDO14625.1 - 3.4e-15 56.2 0.0 9e-15 54.8 0.0 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 EDO14625.1 - 1.2e-13 51.4 1.1 6.9e-13 48.9 0.0 3.0 4 0 0 4 4 2 1 Helicase conserved C-terminal domain S1 PF00575.23 EDO14625.1 - 1.5e-13 50.9 0.4 1.5e-13 50.9 0.4 2.3 2 0 0 2 2 2 1 S1 RNA binding domain DEAD PF00270.29 EDO14625.1 - 7.6e-07 29.1 0.2 1.8e-06 27.9 0.2 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 EDO14625.1 - 6.8e-05 23.2 0.0 0.00024 21.4 0.0 2.0 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EDO14625.1 - 0.001 18.8 0.1 0.002 17.9 0.1 1.4 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.6 EDO14625.1 - 0.0034 17.4 0.3 0.13 12.3 0.3 3.3 1 1 0 1 1 1 1 AAA domain T2SSE PF00437.20 EDO14625.1 - 0.0055 15.8 0.0 0.026 13.6 0.0 2.2 2 0 0 2 2 2 1 Type II/IV secretion system protein PWI PF01480.17 EDO14625.1 - 0.023 15.0 0.6 12 6.4 0.2 3.3 1 1 1 2 2 2 0 PWI domain AAA_19 PF13245.6 EDO14625.1 - 0.046 14.0 0.1 0.11 12.8 0.1 1.6 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 EDO14625.1 - 0.069 12.7 0.0 0.15 11.5 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region Sigma54_activ_2 PF14532.6 EDO14625.1 - 0.1 12.7 0.0 0.28 11.3 0.0 1.7 1 0 0 1 1 1 0 Sigma-54 interaction domain SRP54 PF00448.22 EDO14625.1 - 0.12 12.0 0.2 0.31 10.7 0.2 1.7 1 1 0 1 1 1 0 SRP54-type protein, GTPase domain ABC_tran PF00005.27 EDO14625.1 - 0.17 12.4 6.4 0.39 11.2 0.1 3.6 2 2 0 3 3 3 0 ABC transporter AAA_23 PF13476.6 EDO14625.1 - 0.58 10.6 0.0 0.58 10.6 0.0 3.5 3 0 0 3 3 3 0 AAA domain Proteasome PF00227.26 EDO14626.1 - 1.9e-44 151.4 0.0 2.2e-44 151.2 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit DNA_primase_S PF01896.19 EDO14627.1 - 3.1e-66 222.8 2.6 3.1e-66 222.8 2.6 1.5 2 0 0 2 2 2 1 DNA primase small subunit Cellulase PF00150.18 EDO14628.1 - 8.6e-15 54.9 0.5 2.6e-08 33.6 0.2 3.0 2 1 0 2 2 2 2 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_5_C PF18564.1 EDO14628.1 - 4.3e-14 52.8 0.0 8.1e-14 51.9 0.0 1.4 1 0 0 1 1 1 1 Glycoside hydrolase family 5 C-terminal domain Glyco_hydro_35 PF01301.19 EDO14628.1 - 0.0026 17.4 0.0 0.0047 16.6 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 35 WSC PF01822.19 EDO14629.1 - 6.2e-11 42.3 13.3 6.2e-11 42.3 13.3 2.5 2 0 0 2 2 2 1 WSC domain DUF5305 PF17231.2 EDO14629.1 - 0.0011 18.4 1.6 0.0023 17.4 1.6 1.6 1 0 0 1 1 1 1 Family of unknown function (DUF5305) TctA PF01970.16 EDO14629.1 - 0.045 12.5 1.2 0.091 11.5 1.2 1.5 1 0 0 1 1 1 0 Tripartite tricarboxylate transporter TctA family DUF2408 PF10303.9 EDO14630.1 - 5.8e-63 211.4 21.3 2.6e-41 141.4 0.5 5.0 1 1 4 5 5 5 4 Protein of unknown function (DUF2408) STN1_2 PF09170.10 EDO14630.1 - 0.013 15.7 0.4 0.013 15.7 0.4 2.5 2 0 0 2 2 2 0 CST, Suppressor of cdc thirteen homolog, complex subunit STN1 MtrG PF04210.13 EDO14630.1 - 0.075 12.9 0.4 35 4.4 0.0 3.6 3 0 0 3 3 3 0 Tetrahydromethanopterin S-methyltransferase, subunit G CAP_N PF01213.19 EDO14630.1 - 0.17 11.3 2.7 0.15 11.5 0.2 2.0 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal TMPIT PF07851.13 EDO14630.1 - 0.24 10.6 8.7 0.36 10.0 1.7 2.3 2 0 0 2 2 2 0 TMPIT-like protein DUF4208 PF13907.6 EDO14630.1 - 1.9 9.0 7.3 3.1 8.3 0.2 4.2 3 1 2 5 5 5 0 Domain of unknown function (DUF4208) Laminin_II PF06009.12 EDO14630.1 - 2.8 8.0 11.7 1.3 9.1 1.4 4.2 4 1 0 4 4 4 0 Laminin Domain II CK2S PF15011.6 EDO14630.1 - 4.1 7.3 8.2 0.44 10.4 0.9 2.9 3 1 1 4 4 4 0 Casein Kinase 2 substrate Occludin_ELL PF07303.13 EDO14630.1 - 8.4 7.2 12.1 4.2 8.1 1.4 3.9 3 1 1 4 4 4 0 Occludin homology domain gag_pre-integrs PF13976.6 EDO14632.1 - 0.00014 21.6 0.1 0.00028 20.7 0.1 1.5 1 0 0 1 1 1 1 GAG-pre-integrase domain rve PF00665.26 EDO14632.1 - 0.017 15.3 0.0 0.035 14.3 0.0 1.5 1 0 0 1 1 1 0 Integrase core domain TIG PF01833.24 EDO14632.1 - 0.037 14.1 0.5 1.6 8.8 0.0 2.4 2 0 0 2 2 2 0 IPT/TIG domain Sugar_tr PF00083.24 EDO14633.1 - 4.9e-43 147.6 16.4 1.4e-42 146.2 16.4 1.6 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDO14633.1 - 7.1e-24 84.4 11.6 6e-16 58.3 4.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Ost4 PF10215.9 EDO14633.1 - 0.21 11.4 1.6 13 5.7 0.1 3.0 2 0 0 2 2 2 0 Oligosaccaryltransferase Tubulin PF00091.25 EDO14634.1 - 1.4e-66 224.5 0.0 2e-66 223.9 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EDO14634.1 - 1.4e-49 167.5 0.2 2.1e-49 166.8 0.2 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain MSP PF01716.18 EDO14634.1 - 0.098 11.8 0.0 0.16 11.1 0.0 1.3 1 0 0 1 1 1 0 Manganese-stabilising protein / photosystem II polypeptide ALO PF04030.14 EDO14636.1 - 2.9e-102 341.9 1.4 4.3e-102 341.4 0.4 1.7 2 0 0 2 2 2 1 D-arabinono-1,4-lactone oxidase FAD_binding_4 PF01565.23 EDO14636.1 - 2e-26 92.4 0.0 2.8e-26 91.9 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain UPF0180 PF03698.13 EDO14636.1 - 0.16 12.2 0.3 0.35 11.1 0.0 1.7 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0180) F-box-like PF12937.7 EDO14637.1 - 2e-11 43.6 0.1 3.5e-11 42.8 0.1 1.4 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EDO14637.1 - 6.7e-10 38.6 0.6 1.2e-09 37.7 0.6 1.5 1 0 0 1 1 1 1 F-box domain BBS2_C PF14782.6 EDO14637.1 - 0.0058 15.5 1.9 0.0058 15.5 1.9 1.6 2 0 0 2 2 2 1 Ciliary BBSome complex subunit 2, C-terminal UIM PF02809.20 EDO14637.1 - 0.0066 16.3 4.7 0.0066 16.3 4.7 4.5 4 0 0 4 4 4 2 Ubiquitin interaction motif F-box_4 PF15966.5 EDO14637.1 - 0.014 15.3 0.0 0.029 14.3 0.0 1.6 1 0 0 1 1 1 0 F-box Utp14 PF04615.13 EDO14638.1 - 9.5e-196 652.7 92.5 9.5e-196 652.7 92.5 2.1 1 1 1 2 2 2 1 Utp14 protein Rad10 PF03834.14 EDO14639.1 - 8.8e-38 128.8 1.2 1.1e-37 128.5 1.2 1.1 1 0 0 1 1 1 1 Binding domain of DNA repair protein Ercc1 (rad10/Swi10) NUDE_C PF04880.13 EDO14639.1 - 0.00074 20.0 3.0 0.00099 19.6 3.0 1.2 1 0 0 1 1 1 1 NUDE protein, C-terminal conserved region H_kinase_N PF12282.8 EDO14639.1 - 0.1 12.5 0.2 0.2 11.6 0.2 1.4 1 0 0 1 1 1 0 Signal transduction histidine kinase ERO1 PF04137.15 EDO14640.1 - 5.2e-118 394.3 0.9 5.2e-118 394.3 0.9 2.0 2 0 0 2 2 2 1 Endoplasmic Reticulum Oxidoreductin 1 (ERO1) DUF4939 PF16297.5 EDO14641.1 - 3.1e-06 27.0 0.0 3.5e-06 26.9 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4939) Amidase PF01425.21 EDO14642.1 - 1.2e-94 317.9 0.0 1.7e-94 317.4 0.0 1.2 1 0 0 1 1 1 1 Amidase CT_A_B PF02626.15 EDO14642.1 - 8.8e-85 284.5 0.0 4.9e-84 282.1 0.0 2.1 2 0 0 2 2 2 1 Carboxyltransferase domain, subdomain A and B CPSase_L_D2 PF02786.17 EDO14642.1 - 4.2e-64 215.9 0.0 8e-64 215.0 0.0 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain CT_C_D PF02682.16 EDO14642.1 - 3e-40 138.1 0.0 5.7e-40 137.2 0.0 1.4 1 0 0 1 1 1 1 Carboxyltransferase domain, subdomain C and D Biotin_carb_N PF00289.22 EDO14642.1 - 1.8e-39 134.7 0.1 4.8e-39 133.3 0.1 1.8 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 EDO14642.1 - 8.7e-33 112.7 0.0 2.2e-32 111.4 0.0 1.8 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.22 EDO14642.1 - 1.9e-16 59.6 2.3 1.9e-16 59.6 2.3 2.3 2 0 0 2 2 2 1 Biotin-requiring enzyme Dala_Dala_lig_C PF07478.13 EDO14642.1 - 1.5e-11 44.3 0.0 3.2e-11 43.2 0.0 1.5 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 EDO14642.1 - 1.2e-07 31.5 0.0 2.4e-07 30.5 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_3 PF02655.14 EDO14642.1 - 1.9e-05 24.8 0.1 3.8e-05 23.8 0.1 1.5 1 0 0 1 1 1 1 ATP-grasp domain Biotin_lipoyl_2 PF13533.6 EDO14642.1 - 0.027 14.3 0.9 0.084 12.7 0.2 2.3 2 1 0 2 2 2 0 Biotin-lipoyl like FTR1 PF03239.14 EDO14643.1 - 3.7e-102 341.6 5.4 4.4e-102 341.4 5.4 1.0 1 0 0 1 1 1 1 Iron permease FTR1 family Amidase_5 PF05382.13 EDO14643.1 - 0.0081 16.1 1.6 0.009 15.9 0.4 1.7 2 0 0 2 2 2 1 Bacteriophage peptidoglycan hydrolase DUF2207 PF09972.9 EDO14643.1 - 0.076 11.8 0.0 0.076 11.8 0.0 2.2 2 1 0 2 2 2 0 Predicted membrane protein (DUF2207) CorA PF01544.18 EDO14644.1 - 3.7e-05 23.2 8.7 0.00011 21.6 8.7 1.6 1 1 0 1 1 1 1 CorA-like Mg2+ transporter protein 7TM_GPCR_Srj PF10319.9 EDO14644.1 - 0.036 13.4 0.2 0.7 9.2 0.0 2.1 2 0 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srj HTH_9 PF08221.11 EDO14644.1 - 0.14 12.3 1.7 3.9 7.6 0.1 3.3 3 0 0 3 3 3 0 RNA polymerase III subunit RPC82 helix-turn-helix domain Glyco_transf_15 PF01793.16 EDO14645.1 - 6.5e-118 393.7 8.8 8e-118 393.4 8.8 1.1 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase Abhydrolase_1 PF00561.20 EDO14646.1 - 2.7e-20 73.1 0.0 3.6e-20 72.7 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EDO14646.1 - 7.7e-13 49.6 0.0 9.2e-13 49.3 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EDO14646.1 - 1.3e-11 44.2 0.0 1.9e-11 43.7 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 PGAP1 PF07819.13 EDO14646.1 - 0.00012 21.9 0.0 0.01 15.5 0.0 2.5 3 0 0 3 3 3 1 PGAP1-like protein Ser_hydrolase PF06821.13 EDO14646.1 - 0.00018 21.4 0.0 0.00051 20.0 0.0 1.7 1 0 0 1 1 1 1 Serine hydrolase LIDHydrolase PF10230.9 EDO14646.1 - 0.00024 20.7 0.0 0.00039 20.1 0.0 1.3 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase Thioesterase PF00975.20 EDO14646.1 - 0.00025 21.3 0.0 0.0004 20.6 0.0 1.2 1 0 0 1 1 1 1 Thioesterase domain DUF900 PF05990.12 EDO14646.1 - 0.0003 20.4 0.0 0.0042 16.6 0.0 2.1 2 0 0 2 2 2 1 Alpha/beta hydrolase of unknown function (DUF900) DUF915 PF06028.11 EDO14646.1 - 0.00064 19.1 0.0 0.016 14.6 0.0 2.5 2 1 1 3 3 3 1 Alpha/beta hydrolase of unknown function (DUF915) LCAT PF02450.15 EDO14646.1 - 0.0038 16.5 0.1 0.0092 15.2 0.0 1.6 2 0 0 2 2 2 1 Lecithin:cholesterol acyltransferase Abhydrolase_3 PF07859.13 EDO14646.1 - 0.045 13.6 0.0 0.072 12.9 0.0 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold Palm_thioest PF02089.15 EDO14646.1 - 0.091 12.6 0.0 0.14 12.0 0.0 1.3 1 0 0 1 1 1 0 Palmitoyl protein thioesterase F-box-like PF12937.7 EDO14647.1 - 0.0015 18.4 0.0 0.0033 17.3 0.0 1.6 1 0 0 1 1 1 1 F-box-like DUF3605 PF12239.8 EDO14648.1 - 8.6e-16 58.6 0.1 9.6e-16 58.5 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3605) ResIII PF04851.15 EDO14649.1 - 7.2e-21 74.9 4.0 2.1e-20 73.4 0.0 3.1 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EDO14649.1 - 2.2e-19 69.8 3.0 7e-19 68.2 0.2 3.1 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DEAD PF00270.29 EDO14649.1 - 7.5e-17 61.7 0.4 1.4e-15 57.5 0.0 3.0 4 0 0 4 4 4 1 DEAD/DEAH box helicase SWI2_SNF2 PF18766.1 EDO14649.1 - 0.0015 18.3 2.8 0.0052 16.5 0.0 2.8 2 1 1 3 3 3 1 SWI2/SNF2 ATPase PhoH PF02562.16 EDO14649.1 - 0.047 13.1 0.0 0.11 12.0 0.0 1.6 1 0 0 1 1 1 0 PhoH-like protein Potex_coat PF06184.11 EDO14649.1 - 0.1 12.2 0.0 0.23 11.0 0.0 1.5 1 0 0 1 1 1 0 Potexvirus coat protein Sec3_C PF09763.9 EDO14650.1 - 5.7e-186 620.0 26.5 5.7e-186 620.0 26.5 2.6 2 0 0 2 2 2 1 Exocyst complex component Sec3 Sec3-PIP2_bind PF15277.6 EDO14650.1 - 1.8e-27 95.3 0.4 6.1e-27 93.6 0.4 2.0 1 0 0 1 1 1 1 Exocyst complex component SEC3 N-terminal PIP2 binding PH Aim21 PF11489.8 EDO14651.1 - 2.3e-21 76.5 18.4 2.3e-21 76.5 18.4 3.8 2 1 2 4 4 4 1 Altered inheritance of mitochondria protein 21 DUF3290 PF11694.8 EDO14651.1 - 0.043 13.8 2.6 0.16 12.0 2.6 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3290) EF-hand_4 PF12763.7 EDO14652.1 - 6.5e-27 93.5 0.0 1.7e-13 50.4 0.0 2.6 2 0 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand DUF1720 PF08226.11 EDO14652.1 - 7.1e-19 68.0 170.4 3.6e-07 30.5 28.6 11.1 4 2 4 9 9 9 5 Domain of unknown function (DUF1720) EF-hand_7 PF13499.6 EDO14652.1 - 6.8e-05 23.2 0.0 0.01 16.2 0.0 2.7 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.32 EDO14652.1 - 9.8e-05 21.6 0.0 0.059 12.9 0.0 3.5 3 0 0 3 3 3 1 EF hand Cwf_Cwc_15 PF04889.12 EDO14652.1 - 0.00092 19.0 12.4 0.00092 19.0 12.4 2.5 3 0 0 3 3 3 1 Cwf15/Cwc15 cell cycle control protein EF-hand_6 PF13405.6 EDO14652.1 - 0.0027 17.5 0.0 3.8 7.7 0.0 3.9 4 0 0 4 4 4 1 EF-hand domain Collagen PF01391.18 EDO14652.1 - 0.037 13.8 10.7 0.078 12.7 10.7 1.5 1 0 0 1 1 1 0 Collagen triple helix repeat (20 copies) RSN1_7TM PF02714.15 EDO14654.1 - 1.5e-84 283.5 23.4 1.5e-84 283.5 23.4 1.7 2 0 0 2 2 2 1 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 EDO14654.1 - 6.7e-38 129.9 2.0 6.7e-38 129.9 2.0 2.3 2 0 0 2 2 2 1 Late exocytosis, associated with Golgi transport PHM7_cyt PF14703.6 EDO14654.1 - 1.9e-32 112.9 0.3 3.7e-32 112.0 0.3 1.5 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter Unstab_antitox PF09720.10 EDO14654.1 - 0.13 12.4 0.0 4.1 7.5 0.0 2.3 2 0 0 2 2 2 0 Putative addiction module component DEAD PF00270.29 EDO14655.1 - 7.2e-40 136.6 0.6 1.5e-38 132.3 0.1 2.6 3 0 0 3 3 3 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDO14655.1 - 1.9e-21 76.5 0.0 6.9e-21 74.7 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDO14655.1 - 1.8e-08 34.6 0.0 4.6e-08 33.2 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 EDO14655.1 - 0.0055 16.5 0.0 0.01 15.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_12 PF13087.6 EDO14655.1 - 0.012 15.2 0.2 0.37 10.4 0.1 2.2 2 0 0 2 2 2 0 AAA domain CoaE PF01121.20 EDO14656.1 - 2.9e-59 199.7 0.0 3.6e-59 199.4 0.0 1.1 1 0 0 1 1 1 1 Dephospho-CoA kinase AAA_18 PF13238.6 EDO14656.1 - 6.9e-06 26.6 0.0 2e-05 25.2 0.0 1.8 1 1 0 1 1 1 1 AAA domain PRK PF00485.18 EDO14656.1 - 0.00026 20.8 0.8 0.014 15.2 0.0 2.7 2 2 1 3 3 3 1 Phosphoribulokinase / Uridine kinase family AAA_28 PF13521.6 EDO14656.1 - 0.00094 19.5 0.0 0.0015 18.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain tRNA_lig_kinase PF08303.11 EDO14656.1 - 0.0055 16.8 0.0 0.011 15.8 0.0 1.5 1 0 0 1 1 1 1 tRNA ligase kinase domain AAA_33 PF13671.6 EDO14656.1 - 0.0061 16.7 0.0 0.011 15.9 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.6 EDO14656.1 - 0.0081 16.6 0.0 0.091 13.2 0.0 2.3 2 0 0 2 2 2 1 AAA domain SKI PF01202.22 EDO14656.1 - 0.018 15.1 0.0 0.1 12.7 0.0 2.0 2 0 0 2 2 2 0 Shikimate kinase HTH_16 PF12645.7 EDO14656.1 - 0.14 12.2 0.0 0.59 10.2 0.0 2.0 2 0 0 2 2 2 0 Helix-turn-helix domain ApbA_C PF08546.11 EDO14657.1 - 3e-21 75.9 0.4 4.8e-21 75.3 0.4 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal FHA PF00498.26 EDO14658.1 - 7.1e-18 64.7 2.3 1.6e-16 60.4 0.0 3.6 4 0 0 4 4 4 1 FHA domain Yop-YscD_cpl PF16697.5 EDO14658.1 - 6.1e-05 23.3 0.0 0.00019 21.7 0.0 1.8 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain MbeD_MobD PF04899.12 EDO14658.1 - 0.12 12.5 0.8 0.74 10.0 0.4 2.3 1 1 1 2 2 2 0 MbeD/MobD like Methyltransf_32 PF13679.6 EDO14658.1 - 0.42 10.6 7.2 0.059 13.4 1.6 2.2 2 0 0 2 2 2 0 Methyltransferase domain Mitovir_RNA_pol PF05919.11 EDO14658.1 - 0.99 8.5 8.0 1.5 7.9 8.0 1.2 1 0 0 1 1 1 0 Mitovirus RNA-dependent RNA polymerase DUF5446 PF17522.2 EDO14658.1 - 2.7 8.2 13.6 0.23 11.6 7.0 2.5 1 1 1 2 2 2 0 Family of unknown function (DUF5446) Exonuc_VII_L PF02601.15 EDO14658.1 - 6.6 6.2 10.4 12 5.4 10.4 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit Cation_efflux PF01545.21 EDO14659.1 - 7.9e-45 153.0 12.3 7.9e-45 153.0 12.3 3.3 3 1 0 3 3 3 1 Cation efflux family Topoisom_bac PF01131.20 EDO14660.1 - 4.1e-106 355.4 0.0 5.4e-106 355.1 0.0 1.1 1 0 0 1 1 1 1 DNA topoisomerase Toprim PF01751.22 EDO14660.1 - 6.7e-21 74.5 0.0 2.8e-20 72.5 0.0 2.0 2 0 0 2 2 2 1 Toprim domain DUF4364 PF14277.6 EDO14660.1 - 0.087 12.6 0.1 0.35 10.6 0.1 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4364) EST1_DNA_bind PF10373.9 EDO14661.1 - 4.6e-58 196.9 6.4 4.6e-58 196.9 6.4 2.6 4 0 0 4 4 4 1 Est1 DNA/RNA binding domain EST1 PF10374.9 EDO14661.1 - 6.1e-19 69.0 3.8 6.1e-19 69.0 3.8 3.8 5 0 0 5 5 5 2 Telomerase activating protein Est1 ANAPC4_WD40 PF12894.7 EDO14662.1 - 6.5e-05 23.2 0.1 0.025 14.8 0.0 3.5 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EDO14662.1 - 0.0014 19.4 0.4 2.3 9.2 0.0 3.9 3 0 0 3 3 3 1 WD domain, G-beta repeat DUF2963 PF11178.8 EDO14662.1 - 0.14 11.9 4.7 0.55 10.0 0.1 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2963) RL10P_insert PF17777.1 EDO14662.1 - 0.15 12.1 1.0 17 5.5 0.1 3.7 3 0 0 3 3 3 0 Insertion domain in 60S ribosomal protein L10P Chorion_2 PF03964.15 EDO14662.1 - 0.59 11.0 8.6 1.7 9.5 8.6 1.8 1 0 0 1 1 1 0 Chorion family 2 cobW PF02492.19 EDO14663.1 - 4.4e-43 146.9 0.2 7.4e-43 146.2 0.0 1.5 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.14 EDO14663.1 - 9.2e-05 22.3 0.0 0.0002 21.2 0.0 1.6 1 0 0 1 1 1 1 Cobalamin synthesis protein cobW C-terminal domain AAA_22 PF13401.6 EDO14663.1 - 0.013 15.7 0.1 0.81 10.0 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 EDO14663.1 - 0.013 15.2 0.5 0.041 13.6 0.5 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_16 PF13191.6 EDO14663.1 - 0.032 14.6 0.0 0.074 13.4 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain BsuBI_PstI_RE PF06616.11 EDO14663.1 - 0.041 13.2 0.1 3.1 7.1 0.0 2.8 3 0 0 3 3 3 0 BsuBI/PstI restriction endonuclease domain ABC_tran PF00005.27 EDO14663.1 - 0.041 14.4 0.4 0.12 12.8 0.1 2.0 2 0 0 2 2 2 0 ABC transporter AAA_23 PF13476.6 EDO14663.1 - 0.045 14.3 1.9 0.072 13.6 0.3 2.1 2 1 0 2 2 2 0 AAA domain ATPase_2 PF01637.18 EDO14663.1 - 0.057 13.3 0.1 0.16 11.9 0.1 1.8 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea RsgA_GTPase PF03193.16 EDO14663.1 - 0.091 12.7 1.9 2.6 7.9 0.5 2.4 2 0 0 2 2 2 0 RsgA GTPase AAA_18 PF13238.6 EDO14663.1 - 0.094 13.3 0.0 0.3 11.6 0.0 1.9 1 0 0 1 1 1 0 AAA domain Img2 PF05046.14 EDO14664.1 - 9.3e-19 67.5 0.8 1.7e-18 66.7 0.8 1.4 1 0 0 1 1 1 1 Mitochondrial large subunit ribosomal protein (Img2) PRD_Mga PF08270.11 EDO14664.1 - 0.095 12.4 2.6 0.6 9.8 0.4 2.3 1 1 0 2 2 2 0 M protein trans-acting positive regulator (MGA) PRD domain ubiquitin PF00240.23 EDO14665.1 - 3e-06 26.9 0.7 3.5e-06 26.7 0.7 1.1 1 0 0 1 1 1 1 Ubiquitin family Ubiquitin_4 PF18036.1 EDO14665.1 - 0.04 14.0 0.7 6.4 6.9 0.2 2.0 1 1 1 2 2 2 0 Ubiquitin-like domain Rad60-SLD PF11976.8 EDO14665.1 - 0.053 13.4 0.4 0.06 13.2 0.4 1.1 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like YukD PF08817.10 EDO14665.1 - 0.15 12.7 0.0 0.16 12.7 0.0 1.2 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukD Glucosamine_iso PF01182.20 EDO14666.1 - 4.5e-53 180.4 0.0 7.4e-53 179.7 0.0 1.3 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase PQ-loop PF04193.14 EDO14667.1 - 5.1e-22 77.4 9.9 2.2e-15 56.2 0.0 2.9 2 1 0 2 2 2 2 PQ loop repeat SK_channel PF03530.14 EDO14667.1 - 0.0092 16.0 2.2 0.018 15.0 0.1 2.3 2 0 0 2 2 2 1 Calcium-activated SK potassium channel DAD PF02109.16 EDO14667.1 - 3.2 8.1 8.2 0.39 11.0 2.3 2.5 2 2 0 2 2 2 0 DAD family P34-Arc PF04045.14 EDO14668.1 - 3.2e-93 311.8 3.0 4.2e-93 311.5 3.0 1.1 1 0 0 1 1 1 1 Arp2/3 complex, 34 kD subunit p34-Arc Cation_efflux PF01545.21 EDO14670.1 - 0.032 14.0 15.4 0.85 9.3 15.4 2.2 1 1 0 1 1 1 0 Cation efflux family Thioredoxin PF00085.20 EDO14671.1 - 1.2e-28 99.1 0.1 1.5e-28 98.8 0.1 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 EDO14671.1 - 4.3e-06 27.0 0.1 0.00043 20.5 0.0 2.6 1 1 1 2 2 2 1 Thioredoxin-like Thioredoxin_9 PF14595.6 EDO14671.1 - 5.1e-06 26.3 0.0 6.7e-06 25.9 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin AhpC-TSA PF00578.21 EDO14671.1 - 9.3e-06 25.6 0.0 1.6e-05 24.8 0.0 1.4 1 0 0 1 1 1 1 AhpC/TSA family TraF PF13728.6 EDO14671.1 - 1.4e-05 25.0 0.0 1.8e-05 24.7 0.0 1.1 1 0 0 1 1 1 1 F plasmid transfer operon protein Thioredoxin_2 PF13098.6 EDO14671.1 - 8e-05 23.1 0.1 0.0002 21.7 0.1 1.7 1 1 0 1 1 1 1 Thioredoxin-like domain Redoxin PF08534.10 EDO14671.1 - 0.00015 21.5 0.1 0.0034 17.1 0.0 2.1 1 1 1 2 2 2 1 Redoxin Phosducin PF02114.16 EDO14671.1 - 0.0012 17.9 0.0 0.0015 17.5 0.0 1.1 1 0 0 1 1 1 1 Phosducin OST3_OST6 PF04756.13 EDO14671.1 - 0.0046 16.4 0.1 0.0062 15.9 0.1 1.2 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Toxin-deaminase PF14424.6 EDO14671.1 - 0.0064 16.6 0.0 0.008 16.3 0.0 1.2 1 0 0 1 1 1 1 The BURPS668_1122 family of deaminases Glutaredoxin PF00462.24 EDO14671.1 - 0.053 13.7 0.1 0.14 12.4 0.1 1.7 2 0 0 2 2 2 0 Glutaredoxin NAD1 PF18778.1 EDO14671.1 - 0.076 13.1 0.1 0.095 12.8 0.1 1.2 1 0 0 1 1 1 0 Novel AID APOBEC clade 1 DSBA PF01323.20 EDO14671.1 - 0.094 12.5 0.3 4.2 7.1 0.0 2.1 1 1 1 2 2 2 0 DSBA-like thioredoxin domain Tup_N PF08581.10 EDO14672.1 - 1.2e-26 92.8 12.3 1.2e-26 92.8 12.3 1.7 2 0 0 2 2 2 1 Tup N-terminal Allexi_40kDa PF05549.11 EDO14672.1 - 0.036 13.6 6.8 0.046 13.2 6.8 1.2 1 0 0 1 1 1 0 Allexivirus 40kDa protein TMPIT PF07851.13 EDO14672.1 - 0.053 12.8 9.8 0.07 12.4 9.8 1.1 1 0 0 1 1 1 0 TMPIT-like protein DUF1796 PF08795.10 EDO14672.1 - 0.081 12.9 2.0 0.14 12.1 2.0 1.5 1 1 0 1 1 1 0 Putative papain-like cysteine peptidase (DUF1796) Paralemmin PF03285.15 EDO14672.1 - 0.32 10.5 9.6 0.26 10.8 2.8 2.2 1 1 1 2 2 2 0 Paralemmin V_ATPase_I PF01496.19 EDO14672.1 - 0.64 7.9 8.5 0.76 7.6 8.5 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family SUIM_assoc PF16619.5 EDO14672.1 - 1.2 9.2 17.6 1.1 9.4 3.9 3.1 1 1 1 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Jacalin PF01419.17 EDO14672.1 - 4.5 7.2 5.7 5.9 6.8 4.0 1.8 1 1 1 2 2 2 0 Jacalin-like lectin domain Cofilin_ADF PF00241.20 EDO14673.1 - 2.1e-19 69.5 0.0 4.7e-19 68.4 0.0 1.6 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein SH3_1 PF00018.28 EDO14673.1 - 4.2e-16 58.3 0.8 1.2e-15 56.8 0.8 1.9 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EDO14673.1 - 6.1e-14 51.6 0.5 1.8e-13 50.1 0.5 1.9 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EDO14673.1 - 7.4e-08 32.0 0.0 1.5e-07 31.0 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain CAP PF00188.26 EDO14674.1 - 2.4e-12 47.8 2.4 2.9e-12 47.5 2.4 1.1 1 0 0 1 1 1 1 Cysteine-rich secretory protein family KH_1 PF00013.29 EDO14675.1 - 4.2e-86 282.8 38.6 1.6e-12 47.0 0.1 12.0 12 0 0 12 12 12 10 KH domain KH_2 PF07650.17 EDO14675.1 - 1.5e-12 47.1 17.4 7.3e-05 22.5 0.1 7.2 7 1 0 7 7 7 5 KH domain KH_4 PF13083.6 EDO14675.1 - 2.9e-05 23.9 6.0 0.0061 16.4 0.1 5.2 4 0 0 4 4 4 1 KH domain KH_5 PF13184.6 EDO14675.1 - 5e-05 23.3 19.7 0.26 11.4 0.5 6.9 6 0 0 6 6 6 2 NusA-like KH domain BMC PF00936.19 EDO14675.1 - 0.06 13.3 1.3 25 4.9 0.1 4.7 5 0 0 5 5 5 0 BMC domain TrkA_C PF02080.21 EDO14675.1 - 0.078 12.8 0.2 52 3.8 0.0 4.1 4 0 0 4 4 4 0 TrkA-C domain DUF948 PF06103.11 EDO14675.1 - 0.21 11.9 4.1 3.5 8.0 0.1 4.2 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF948) YpjP PF14005.6 EDO14675.1 - 0.4 10.7 4.0 0.26 11.3 0.5 2.6 2 0 0 2 2 2 0 YpjP-like protein CS PF04969.16 EDO14675.1 - 4.6 8.3 7.1 7.8 7.6 0.1 4.2 4 1 1 5 5 5 0 CS domain Mitofilin PF09731.9 EDO14676.1 - 2.2e-36 125.9 21.4 3.6e-29 102.1 17.7 2.7 2 1 0 2 2 2 2 Mitochondrial inner membrane protein OHCU_decarbox PF09349.10 EDO14676.1 - 0.0022 18.5 0.1 0.011 16.2 0.0 2.2 2 0 0 2 2 2 1 OHCU decarboxylase Noelin-1 PF12308.8 EDO14676.1 - 0.023 14.7 1.1 0.023 14.7 1.1 2.5 2 1 0 2 2 2 0 Neurogenesis glycoprotein DUF4790 PF16037.5 EDO14676.1 - 0.036 14.5 0.6 0.11 12.9 0.1 2.0 1 1 0 2 2 2 0 Domain of unknown function (DUF4790) HsbA PF12296.8 EDO14676.1 - 0.14 12.6 3.7 0.76 10.2 0.1 3.0 2 1 1 3 3 3 0 Hydrophobic surface binding protein A DUF4164 PF13747.6 EDO14676.1 - 0.15 12.3 0.2 0.15 12.3 0.2 2.9 3 1 0 3 3 3 0 Domain of unknown function (DUF4164) DUF1818 PF08848.11 EDO14676.1 - 4.5 7.4 6.1 10 6.2 0.1 3.1 2 1 1 3 3 3 0 Domain of unknown function (DUF1818) PRESAN PF09687.10 EDO14676.1 - 5.5 7.6 17.1 4.7 7.8 12.2 3.2 2 1 1 3 3 3 0 Plasmodium RESA N-terminal Actin PF00022.19 EDO14677.1 - 2.3e-95 319.6 0.0 3.4e-94 315.8 0.0 2.0 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 EDO14677.1 - 0.0089 14.9 0.0 0.18 10.6 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein IBR PF01485.21 EDO14678.1 - 2e-15 56.7 50.7 5.8e-09 36.0 13.4 4.0 3 1 1 4 4 4 2 IBR domain, a half RING-finger domain zf-C3HC4 PF00097.25 EDO14678.1 - 2e-06 27.6 13.3 2e-06 27.6 13.3 4.9 4 1 1 5 5 5 1 Zinc finger, C3HC4 type (RING finger) DUF1810 PF08837.11 EDO14678.1 - 0.075 12.8 0.0 0.19 11.6 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1810) MALT1_Ig PF18703.1 EDO14678.1 - 0.14 12.2 0.8 0.46 10.5 0.2 2.1 1 1 1 2 2 2 0 MALT1 Ig-like domain DUF3808 PF10300.9 EDO14679.1 - 3.4e-178 593.3 1.0 4.1e-178 593.0 1.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3808) HrpB1_HrpK PF09613.10 EDO14679.1 - 0.1 12.2 0.1 0.34 10.5 0.1 1.8 1 0 0 1 1 1 0 Bacterial type III secretion protein (HrpB1_HrpK) EF-hand_4 PF12763.7 EDO14680.1 - 9.4e-05 22.3 0.7 0.0005 20.0 0.1 2.4 2 0 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand EF-hand_1 PF00036.32 EDO14680.1 - 0.52 10.0 1.9 0.72 9.5 0.0 2.4 3 0 0 3 3 3 0 EF hand Ribosomal_L24e PF01246.20 EDO14681.1 - 4.6e-29 100.5 5.5 6.6e-29 99.9 5.5 1.3 1 0 0 1 1 1 1 Ribosomal protein L24e DUF1091 PF06477.13 EDO14681.1 - 0.059 13.9 0.1 0.12 12.9 0.0 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1091) FabA PF07977.13 EDO14681.1 - 0.2 11.3 0.5 0.31 10.6 0.4 1.5 1 1 0 1 1 1 0 FabA-like domain Adaptin_N PF01602.20 EDO14682.1 - 1.2e-92 311.2 22.5 1.5e-92 310.8 22.5 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 EDO14682.1 - 5.4e-12 46.1 2.6 5.4e-12 46.1 2.6 3.6 3 1 1 4 4 4 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EDO14682.1 - 1.5e-05 25.3 0.1 2 8.9 0.0 4.2 4 0 0 4 4 4 2 HEAT repeats VHS PF00790.19 EDO14682.1 - 0.11 12.4 2.3 5.5 6.8 0.0 3.9 4 0 0 4 4 4 0 VHS domain RTP1_C1 PF10363.9 EDO14682.1 - 1.1 9.4 3.8 2 8.6 0.5 2.9 2 0 0 2 2 2 0 Required for nuclear transport of RNA pol II C-terminus 1 CMS1 PF14617.6 EDO14683.1 - 4.3e-16 59.0 14.0 4.3e-16 59.0 14.0 2.6 1 1 1 2 2 2 1 U3-containing 90S pre-ribosomal complex subunit PTPS PF01242.19 EDO14683.1 - 0.25 11.3 2.0 1.5 8.8 2.0 2.3 1 1 0 1 1 1 0 6-pyruvoyl tetrahydropterin synthase zf-C2H2 PF00096.26 EDO14684.1 - 1.6e-07 31.4 18.4 0.0018 18.6 2.5 3.7 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EDO14684.1 - 0.00036 21.1 15.3 0.07 14.0 1.9 3.9 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EDO14684.1 - 0.025 14.9 17.7 1.5 9.2 2.0 3.9 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-H2C2_2 PF13465.6 EDO14684.1 - 0.036 14.5 0.2 0.036 14.5 0.2 3.9 3 1 0 3 3 3 0 Zinc-finger double domain zf_ZIC PF18366.1 EDO14684.1 - 1.3 9.2 4.9 3.9 7.7 0.1 3.0 3 0 0 3 3 3 0 Zic proteins zinc finger domain 2-oxoacid_dh PF00198.23 EDO14685.1 - 3.2e-78 262.4 0.1 4.2e-78 262.0 0.1 1.1 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 EDO14685.1 - 2.6e-16 59.2 0.5 5.1e-16 58.3 0.5 1.5 1 0 0 1 1 1 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.6 EDO14685.1 - 0.0022 17.8 0.0 0.13 12.1 0.0 2.4 1 1 1 2 2 2 1 Biotin-lipoyl like HlyD_3 PF13437.6 EDO14685.1 - 0.003 18.2 0.1 0.034 14.9 0.0 2.3 1 1 1 2 2 2 1 HlyD family secretion protein GCV_H PF01597.19 EDO14685.1 - 0.024 14.5 0.1 0.059 13.3 0.1 1.8 1 0 0 1 1 1 0 Glycine cleavage H-protein BioT2 PF15368.6 EDO14685.1 - 0.052 13.5 1.5 0.057 13.4 0.1 1.7 2 0 0 2 2 2 0 Spermatogenesis family BioT2 RnfC_N PF13375.6 EDO14685.1 - 0.09 12.7 0.0 0.32 11.0 0.0 1.8 1 1 0 1 1 1 0 RnfC Barrel sandwich hybrid domain MSA-2c PF12238.8 EDO14685.1 - 9.9 6.1 8.3 8.8 6.3 6.8 1.7 2 0 0 2 2 2 0 Merozoite surface antigen 2c Mcp5_PH PF12814.7 EDO14686.1 - 5.9e-45 152.3 1.5 2e-44 150.6 0.0 2.4 2 0 0 2 2 2 1 Meiotic cell cortex C-terminal pleckstrin homology PH PF00169.29 EDO14686.1 - 0.00025 21.5 0.6 0.0018 18.8 0.0 2.9 2 0 0 2 2 2 1 PH domain PH_2 PF08458.10 EDO14686.1 - 0.026 14.9 0.0 0.078 13.3 0.0 1.9 1 0 0 1 1 1 0 Plant pleckstrin homology-like region ISG65-75 PF11727.8 EDO14686.1 - 0.037 13.3 4.8 0.13 11.5 2.2 3.0 2 0 0 2 2 2 0 Invariant surface glycoprotein zf-CCCH PF00642.24 EDO14687.1 - 9.4e-19 66.9 17.3 6.1e-10 38.8 4.5 2.3 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 EDO14687.1 - 1.5e-07 31.2 21.7 1.9e-05 24.6 7.5 2.3 2 0 0 2 2 2 2 Zinc finger domain zf-CCCH_4 PF18044.1 EDO14687.1 - 8.9e-06 25.4 16.8 1.8e-05 24.4 3.2 2.2 2 0 0 2 2 2 2 CCCH-type zinc finger Torus PF16131.5 EDO14687.1 - 0.017 15.8 2.1 0.017 15.8 2.1 3.0 2 1 1 3 3 3 0 Torus domain zf-CCCH_2 PF14608.6 EDO14687.1 - 0.11 13.0 15.7 0.13 12.8 2.8 2.4 2 0 0 2 2 2 0 RNA-binding, Nab2-type zinc finger Defensin_int PF17858.1 EDO14687.1 - 0.23 11.5 1.1 0.42 10.6 0.5 1.7 2 0 0 2 2 2 0 Platypus intermediate defensin-like peptide MAGUK_N_PEST PF10608.9 EDO14687.1 - 5.4 7.5 7.2 17 5.9 2.1 2.6 1 1 1 2 2 2 0 Polyubiquitination (PEST) N-terminal domain of MAGUK ENTH PF01417.20 EDO14688.1 - 1.1e-32 112.8 0.8 1.1e-32 112.8 0.8 1.7 2 0 0 2 2 2 1 ENTH domain Draxin PF15550.6 EDO14688.1 - 0.036 13.9 10.6 0.06 13.2 10.6 1.3 1 0 0 1 1 1 0 Draxin SOBP PF15279.6 EDO14688.1 - 0.78 10.3 10.1 1.1 9.8 10.1 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein Mucin PF01456.17 EDO14688.1 - 5.7 6.9 18.6 12 5.8 18.6 1.5 1 0 0 1 1 1 0 Mucin-like glycoprotein Pro_isomerase PF00160.21 EDO14689.1 - 2.3e-46 158.0 0.0 2.5e-46 157.8 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Ku_N PF03731.15 EDO14691.1 - 8.7e-36 123.7 1.0 1.2e-35 123.2 1.0 1.2 1 0 0 1 1 1 1 Ku70/Ku80 N-terminal alpha/beta domain Ku PF02735.16 EDO14691.1 - 2.8e-30 105.6 0.1 5.6e-30 104.6 0.1 1.4 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain VWA PF00092.28 EDO14691.1 - 0.058 13.7 0.0 0.15 12.3 0.0 1.6 1 0 0 1 1 1 0 von Willebrand factor type A domain Ras_bdg_2 PF14847.6 EDO14691.1 - 0.23 11.8 1.4 3.7 8.0 0.0 3.0 2 1 0 3 3 3 0 Ras-binding domain of Byr2 Rit1_C PF17184.4 EDO14692.1 - 6.6e-96 320.9 0.0 2.2e-95 319.2 0.0 1.7 2 0 0 2 2 2 1 Rit1 N-terminal domain Init_tRNA_PT PF04179.12 EDO14692.1 - 6.1e-27 94.1 0.6 1.4e-26 92.9 0.6 1.6 1 0 0 1 1 1 1 Rit1 DUSP-like domain ATP13 PF12921.7 EDO14693.1 - 6.2e-30 103.4 0.7 3.2e-29 101.1 0.1 2.5 2 0 0 2 2 2 1 Mitochondrial ATPase expression Thr_synth_N PF14821.6 EDO14693.1 - 0.043 14.0 0.7 0.92 9.8 0.1 3.5 3 2 1 4 4 4 0 Threonine synthase N terminus Gb3_synth PF04572.12 EDO14693.1 - 0.097 12.9 0.7 0.79 9.9 0.1 2.4 2 0 0 2 2 2 0 Alpha 1,4-glycosyltransferase conserved region YebO PF13974.6 EDO14693.1 - 0.2 11.8 2.3 0.49 10.5 2.3 1.7 1 0 0 1 1 1 0 YebO-like protein PIG-L PF02585.17 EDO14694.1 - 2.4e-17 63.8 0.2 3.7e-17 63.2 0.2 1.3 1 0 0 1 1 1 1 GlcNAc-PI de-N-acetylase Nab6_mRNP_bdg PF10567.9 EDO14695.1 - 3.5e-88 296.1 10.6 3.5e-88 296.1 10.6 2.6 3 0 0 3 3 3 1 RNA-recognition motif RRM PF10378.9 EDO14695.1 - 9.9e-22 76.4 7.0 9.9e-22 76.4 7.0 4.3 4 1 0 4 4 4 1 Putative RRM domain RVP PF00077.20 EDO14695.1 - 0.12 12.6 0.2 0.28 11.5 0.2 1.6 1 0 0 1 1 1 0 Retroviral aspartyl protease TFIIA PF03153.13 EDO14695.1 - 4.6 7.1 34.7 29 4.5 34.7 1.9 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Gti1_Pac2 PF09729.9 EDO14695.1 - 5.3 7.1 17.3 0.47 10.5 2.1 3.0 3 0 0 3 3 3 0 Gti1/Pac2 family RRM_1 PF00076.22 EDO14696.1 - 8e-07 28.8 0.2 0.0017 18.1 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) S-methyl_trans PF02574.16 EDO14697.1 - 6.9e-54 183.4 0.0 8e-54 183.2 0.0 1.0 1 0 0 1 1 1 1 Homocysteine S-methyltransferase Kelch_1 PF01344.25 EDO14697.1 - 0.032 13.8 0.1 0.13 11.9 0.0 2.0 2 0 0 2 2 2 0 Kelch motif PGM_PMM_I PF02878.16 EDO14698.1 - 1.9e-40 137.8 0.0 3.4e-40 136.9 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_II PF02879.16 EDO14698.1 - 4.7e-20 72.1 0.0 1.4e-19 70.6 0.0 1.9 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_III PF02880.16 EDO14698.1 - 4.2e-15 55.9 0.0 9.4e-15 54.8 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_IV PF00408.20 EDO14698.1 - 4.4e-06 26.8 0.0 1.1e-05 25.5 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain NIF PF03031.18 EDO14699.1 - 6.6e-26 90.9 0.3 3.8e-25 88.5 0.0 2.4 2 0 0 2 2 2 1 NLI interacting factor-like phosphatase BRCT PF00533.26 EDO14699.1 - 1.1e-13 51.3 0.2 4.4e-13 49.4 0.2 2.0 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 EDO14699.1 - 6.3e-06 26.0 0.1 1.8e-05 24.6 0.1 1.8 1 0 0 1 1 1 1 twin BRCT domain BRCT_2 PF16589.5 EDO14699.1 - 0.017 15.5 0.0 0.058 13.8 0.0 2.0 1 0 0 1 1 1 0 BRCT domain, a BRCA1 C-terminus domain LIG3_BRCT PF16759.5 EDO14699.1 - 0.072 13.4 0.2 0.22 11.9 0.2 1.8 1 0 0 1 1 1 0 DNA ligase 3 BRCT domain ATP-synt_J PF04911.12 EDO14699.1 - 0.13 11.8 0.1 0.29 10.7 0.1 1.5 1 0 0 1 1 1 0 ATP synthase j chain LMBR1 PF04791.16 EDO14699.1 - 1.2 7.9 7.4 0.2 10.5 3.5 1.5 2 0 0 2 2 2 0 LMBR1-like membrane protein TAF8_C PF10406.9 EDO14700.1 - 8.7e-20 71.0 0.2 8.7e-20 71.0 0.2 3.3 3 0 0 3 3 3 1 Transcription factor TFIID complex subunit 8 C-term ubiquitin PF00240.23 EDO14701.1 - 6.5e-21 73.9 1.4 1.1e-20 73.1 1.4 1.3 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 EDO14701.1 - 3.3e-09 36.4 0.8 5.6e-09 35.7 0.8 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like UBA PF00627.31 EDO14701.1 - 1.6e-05 24.7 0.8 3.1e-05 23.8 0.0 2.0 2 0 0 2 2 2 1 UBA/TS-N domain Ubiquitin_2 PF14560.6 EDO14701.1 - 0.00074 19.9 0.2 0.0017 18.8 0.2 1.6 1 0 0 1 1 1 1 Ubiquitin-like domain TBK1_ULD PF18396.1 EDO14701.1 - 0.00084 19.2 0.1 0.0015 18.4 0.1 1.4 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain Rad60-SLD_2 PF13881.6 EDO14701.1 - 0.0049 17.0 0.3 0.014 15.5 0.3 1.8 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like HOIP-UBA PF16678.5 EDO14701.1 - 0.009 16.0 0.0 0.018 15.0 0.0 1.4 1 0 0 1 1 1 1 HOIP UBA domain pair DUF2407 PF10302.9 EDO14701.1 - 0.033 14.7 0.0 0.077 13.6 0.0 1.6 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain GerD PF17898.1 EDO14701.1 - 1.3 9.0 8.5 2.7 8.0 8.5 1.6 1 0 0 1 1 1 0 Spore germination GerD central core domain DUF5314 PF17241.2 EDO14702.1 - 1e-49 168.9 4.3 3e-49 167.4 4.3 1.8 1 0 0 1 1 1 1 Family of unknown function (DUF5314) rve PF00665.26 EDO14702.1 - 1.5e-19 70.4 0.0 3e-19 69.4 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain gag_pre-integrs PF13976.6 EDO14702.1 - 8.3e-13 48.0 0.0 3.6e-12 46.0 0.0 2.2 2 0 0 2 2 2 1 GAG-pre-integrase domain eIF3g PF12353.8 EDO14702.1 - 0.015 15.7 0.6 0.036 14.5 0.6 1.6 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit G RVT_2 PF07727.14 EDO14703.1 - 8.9e-54 182.7 0.0 1.3e-53 182.2 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Sir1 PF11603.8 EDO14704.1 - 1.3e-07 32.1 3.8 6.4e-07 29.9 1.3 2.8 2 1 0 2 2 2 1 Regulatory protein Sir1 Sir1 PF11603.8 EDO14706.1 - 1.2e-33 116.1 7.5 1.9e-33 115.5 4.3 2.9 2 0 0 2 2 2 1 Regulatory protein Sir1 Peptidase_C39_2 PF13529.6 EDO14706.1 - 0.027 15.0 0.0 0.23 12.0 0.0 2.3 2 0 0 2 2 2 0 Peptidase_C39 like family NAM-associated PF14303.6 EDO14706.1 - 0.067 13.9 0.3 0.11 13.2 0.3 1.4 1 0 0 1 1 1 0 No apical meristem-associated C-terminal domain ADH_zinc_N PF00107.26 EDO14707.1 - 9.4e-13 48.3 0.1 1.6e-12 47.5 0.1 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EDO14707.1 - 0.0016 18.3 0.2 0.045 13.6 0.1 2.3 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 EDO14707.1 - 0.023 15.8 0.1 0.048 14.7 0.1 1.6 1 0 0 1 1 1 0 Zinc-binding dehydrogenase Flavodoxin_2 PF02525.17 EDO14708.1 - 2.2e-51 174.4 0.0 2.7e-51 174.1 0.0 1.1 1 0 0 1 1 1 1 Flavodoxin-like fold FMN_red PF03358.15 EDO14708.1 - 2.2e-12 47.0 0.0 4.9e-12 45.8 0.0 1.5 1 1 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_4 PF12682.7 EDO14708.1 - 0.12 12.1 0.2 1.4 8.6 0.3 2.2 2 1 0 2 2 2 0 Flavodoxin Hph PF13694.6 EDO14709.1 - 2.7e-58 197.3 13.7 2.7e-58 197.3 13.7 2.8 4 0 0 4 4 4 1 Sec63/Sec62 complex-interacting family SPG48 PF14764.6 EDO14709.1 - 0.0021 18.5 2.3 0.0024 18.3 0.9 1.8 2 0 0 2 2 2 1 AP-5 complex subunit, vesicle trafficking bZIP_C PF12498.8 EDO14709.1 - 0.39 11.7 11.4 0.42 11.6 0.8 3.9 3 1 1 4 4 4 0 Basic leucine-zipper C terminal TFIIF_beta_N PF17683.1 EDO14709.1 - 2.3 8.9 6.6 0.36 11.5 1.8 2.2 2 0 0 2 2 2 0 TFIIF, beta subunit N-terminus Saw1 PF11561.8 EDO14710.1 - 1.4e-89 299.8 10.7 1.6e-89 299.7 10.7 1.0 1 0 0 1 1 1 1 Single strand annealing-weakened 1 Aldedh PF00171.22 EDO14711.1 - 1.4e-17 63.4 0.1 7.3e-12 44.5 0.0 2.2 2 0 0 2 2 2 2 Aldehyde dehydrogenase family URO-D PF01208.17 EDO14711.1 - 0.01 15.0 0.0 0.015 14.5 0.0 1.3 1 0 0 1 1 1 1 Uroporphyrinogen decarboxylase (URO-D) Ribosomal_L28e PF01778.17 EDO14712.1 - 6.2e-39 133.3 4.2 6.2e-39 133.3 4.2 1.7 2 0 0 2 2 2 1 Ribosomal L28e protein family Mak16 PF04874.14 EDO14712.1 - 3.4e-30 104.6 17.6 3.4e-30 104.6 17.6 2.7 2 1 1 3 3 3 1 Mak16 protein C-terminal region BUD22 PF09073.10 EDO14712.1 - 0.0011 18.5 18.4 0.0013 18.1 18.4 1.1 1 0 0 1 1 1 1 BUD22 PYC_OADA PF02436.18 EDO14712.1 - 0.0091 15.8 1.8 0.019 14.7 1.8 1.5 1 0 0 1 1 1 1 Conserved carboxylase domain Ribosomal_L24e PF01246.20 EDO14712.1 - 0.075 13.3 0.2 0.19 12.0 0.2 1.7 1 0 0 1 1 1 0 Ribosomal protein L24e DUF2462 PF09495.10 EDO14712.1 - 5.3 7.9 10.5 3.5 8.4 1.0 3.5 3 1 0 3 3 3 0 Protein of unknown function (DUF2462) RasGEF PF00617.19 EDO14713.1 - 9.2e-40 136.7 2.7 9.2e-40 136.7 2.7 2.6 2 0 0 2 2 2 1 RasGEF domain RasGEF_N PF00618.20 EDO14713.1 - 8.4e-16 58.1 0.6 8.4e-16 58.1 0.6 4.1 4 1 0 4 4 4 1 RasGEF N-terminal motif LDB19 PF13002.7 EDO14714.1 - 9.9e-98 325.5 0.6 1.5e-97 325.0 0.6 1.3 1 0 0 1 1 1 1 Arrestin_N terminal like Arrestin_N PF00339.29 EDO14714.1 - 0.00034 20.7 0.1 0.0011 19.0 0.1 1.9 2 0 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain Cwf_Cwc_15 PF04889.12 EDO14714.1 - 0.38 10.5 14.0 0.83 9.3 14.0 1.5 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein CDC27 PF09507.10 EDO14714.1 - 4 6.7 18.1 0.48 9.8 13.4 1.7 2 0 0 2 2 2 0 DNA polymerase subunit Cdc27 RR_TM4-6 PF06459.12 EDO14714.1 - 7.8 6.2 9.9 15 5.3 9.9 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 PMT_4TMC PF16192.5 EDO14715.1 - 8.6e-64 214.8 13.3 1.1e-63 214.5 13.3 1.1 1 0 0 1 1 1 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 EDO14715.1 - 2.3e-20 73.2 0.0 3.2e-20 72.7 0.0 1.2 1 0 0 1 1 1 1 MIR domain Abhydrolase_9_N PF15420.6 EDO14715.1 - 0.16 12.0 1.6 0.27 11.2 0.2 1.9 1 1 1 2 2 2 0 Alpha/beta-hydrolase family N-terminus Ribosomal_L7Ae PF01248.26 EDO14716.1 - 2.3e-23 81.7 0.3 3.8e-23 81.0 0.3 1.4 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family RNase_P_pop3 PF08228.11 EDO14716.1 - 0.00075 19.6 0.1 0.0015 18.6 0.1 1.5 1 1 0 1 1 1 1 RNase P subunit Pop3 RRM_1 PF00076.22 EDO14717.1 - 1.2e-15 57.1 5.9 5.2e-07 29.4 0.4 3.3 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EDO14717.1 - 0.005 16.9 0.0 1.9 8.7 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif DRAT PF07357.11 EDO14717.1 - 0.013 14.7 0.2 0.02 14.1 0.2 1.3 1 0 0 1 1 1 0 Dinitrogenase reductase ADP-ribosyltransferase (DRAT) FAM101 PF15068.6 EDO14717.1 - 0.031 14.2 0.1 0.043 13.8 0.1 1.2 1 0 0 1 1 1 0 FAM101 family DNA_pol3_a_NI PF14480.6 EDO14717.1 - 0.035 14.1 4.2 0.039 14.0 0.3 2.4 2 0 0 2 2 2 0 DNA polymerase III polC-type N-terminus I ABC_tran PF00005.27 EDO14718.1 - 2.8e-58 196.3 0.2 1.2e-33 116.6 0.1 2.6 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 EDO14718.1 - 8.8e-52 176.4 35.6 3.8e-32 112.0 14.5 4.1 3 1 0 3 3 3 3 ABC transporter transmembrane region AAA_21 PF13304.6 EDO14718.1 - 1e-10 41.9 0.3 0.00094 19.1 0.0 3.6 2 1 1 3 3 3 3 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EDO14718.1 - 4.4e-10 39.4 4.8 0.00017 21.1 2.5 4.0 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 EDO14718.1 - 2.8e-08 34.5 14.6 4.9e-05 23.9 0.3 4.2 2 1 2 4 4 3 2 AAA domain AAA_29 PF13555.6 EDO14718.1 - 1.3e-07 31.3 0.8 0.0028 17.4 0.0 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EDO14718.1 - 9e-07 28.9 0.1 0.0085 16.0 0.1 2.4 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 EDO14718.1 - 2.6e-06 27.5 0.2 0.0036 17.4 0.1 2.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_22 PF13401.6 EDO14718.1 - 3.2e-05 24.2 0.1 0.48 10.7 0.1 3.4 2 1 0 2 2 2 2 AAA domain T2SSE PF00437.20 EDO14718.1 - 7.2e-05 22.0 0.1 0.0078 15.3 0.0 2.3 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_15 PF13175.6 EDO14718.1 - 0.00024 20.9 5.3 0.0036 17.1 0.6 4.3 4 1 1 5 5 5 2 AAA ATPase domain AAA_16 PF13191.6 EDO14718.1 - 0.00026 21.4 0.3 0.79 10.1 0.0 2.9 3 0 0 3 3 3 2 AAA ATPase domain DUF87 PF01935.17 EDO14718.1 - 0.00039 20.6 0.2 0.43 10.6 0.1 3.4 3 0 0 3 3 3 1 Helicase HerA, central domain AAA_24 PF13479.6 EDO14718.1 - 0.00048 19.9 1.6 0.022 14.5 0.0 2.7 3 0 0 3 3 2 1 AAA domain AAA_7 PF12775.7 EDO14718.1 - 0.00065 19.3 0.1 0.42 10.1 0.0 2.6 2 0 0 2 2 2 1 P-loop containing dynein motor region ATP_bind_1 PF03029.17 EDO14718.1 - 0.0011 18.8 0.0 7.9 6.2 0.0 3.8 4 0 0 4 4 4 0 Conserved hypothetical ATP binding protein AAA PF00004.29 EDO14718.1 - 0.0018 18.7 0.1 6 7.3 0.0 3.5 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Dynamin_N PF00350.23 EDO14718.1 - 0.0048 17.0 0.7 2.3 8.2 0.0 3.3 3 0 0 3 3 3 1 Dynamin family FtsK_SpoIIIE PF01580.18 EDO14718.1 - 0.008 15.6 0.0 2.9 7.2 0.0 2.3 2 0 0 2 2 2 1 FtsK/SpoIIIE family Zeta_toxin PF06414.12 EDO14718.1 - 0.0088 15.3 0.0 0.99 8.6 0.0 2.4 2 0 0 2 2 2 1 Zeta toxin AAA_30 PF13604.6 EDO14718.1 - 0.011 15.5 0.1 4.6 6.9 0.0 2.5 2 0 0 2 2 2 0 AAA domain cobW PF02492.19 EDO14718.1 - 0.016 14.8 0.2 0.87 9.2 0.0 2.5 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Guanylate_kin PF00625.21 EDO14718.1 - 0.04 13.6 0.0 2.1 8.0 0.0 2.7 2 0 0 2 2 2 0 Guanylate kinase Roc PF08477.13 EDO14718.1 - 0.058 13.6 1.8 15 5.9 0.1 3.1 3 0 0 3 3 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_18 PF13238.6 EDO14718.1 - 0.087 13.4 0.0 20 5.8 0.0 2.8 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 EDO14718.1 - 0.088 12.5 0.2 4.9 6.8 0.0 2.9 3 0 0 3 3 3 0 IstB-like ATP binding protein AAA_33 PF13671.6 EDO14718.1 - 0.099 12.8 0.0 6.9 6.8 0.0 2.5 2 0 0 2 2 2 0 AAA domain ResIII PF04851.15 EDO14718.1 - 0.11 12.5 0.0 7.9 6.5 0.0 2.8 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit AA_permease_2 PF13520.6 EDO14719.1 - 7.9e-68 229.2 44.5 9.8e-68 228.9 44.5 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EDO14719.1 - 1.6e-13 50.1 39.9 2.1e-13 49.7 39.9 1.2 1 0 0 1 1 1 1 Amino acid permease DUF2417 PF10329.9 EDO14719.1 - 0.0025 17.3 1.2 0.0025 17.3 1.2 2.7 3 0 0 3 3 3 1 Region of unknown function (DUF2417) SET PF00856.28 EDO14720.1 - 6.2e-10 39.7 0.6 1.3e-09 38.7 0.1 2.0 2 0 0 2 2 2 1 SET domain RRM_1 PF00076.22 EDO14721.1 - 9e-19 67.1 1.3 1.2e-18 66.7 0.1 1.8 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP PF00658.18 EDO14721.1 - 2.8e-18 65.8 0.1 2.8e-18 65.8 0.1 2.6 3 0 0 3 3 3 1 Poly-adenylate binding protein, unique domain UQ_con PF00179.26 EDO14722.1 - 3.4e-48 162.9 0.0 3.9e-48 162.7 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UEV PF05743.13 EDO14722.1 - 0.013 15.4 0.0 0.023 14.6 0.0 1.5 1 1 0 1 1 1 0 UEV domain Prok-E2_B PF14461.6 EDO14722.1 - 0.017 14.8 0.0 0.022 14.4 0.0 1.2 1 0 0 1 1 1 0 Prokaryotic E2 family B PhoLip_ATPase_N PF16209.5 EDO14723.1 - 4.4e-19 67.9 2.1 8e-19 67.1 2.1 1.4 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal IGF2_C PF08365.11 EDO14723.1 - 0.039 14.0 0.1 0.081 13.0 0.1 1.5 1 0 0 1 1 1 0 Insulin-like growth factor II E-peptide PhoLip_ATPase_C PF16212.5 EDO14724.1 - 7.7e-79 265.0 29.9 7.7e-79 265.0 29.9 1.9 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal Cation_ATPase PF13246.6 EDO14724.1 - 3.6e-11 43.0 0.0 1.8e-10 40.7 0.0 2.1 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 EDO14724.1 - 1.6e-10 41.6 0.7 9.8e-06 26.0 0.2 2.6 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 EDO14724.1 - 0.0014 18.4 0.2 0.0034 17.2 0.2 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 EDO14724.1 - 0.0035 17.8 0.1 0.43 10.9 0.1 2.5 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase PolyA_pol PF01743.20 EDO14725.1 - 1.8e-31 109.2 0.1 3.3e-31 108.3 0.1 1.5 1 0 0 1 1 1 1 Poly A polymerase head domain PolyA_pol_RNAbd PF12627.7 EDO14725.1 - 1.7e-05 24.4 0.0 4.6e-05 23.1 0.0 1.7 1 0 0 1 1 1 1 Probable RNA and SrmB- binding site of polymerase A tRNA_NucTran2_2 PF13735.6 EDO14725.1 - 0.0022 18.0 0.4 0.014 15.4 0.4 2.4 1 1 0 1 1 1 1 tRNA nucleotidyltransferase domain 2 putative MutS_V PF00488.21 EDO14726.1 - 2.5e-65 220.0 0.2 4.4e-64 216.0 0.3 2.3 2 0 0 2 2 2 1 MutS domain V MutS_III PF05192.18 EDO14726.1 - 2.3e-35 122.6 0.3 5.1e-35 121.4 0.1 1.7 2 0 0 2 2 2 1 MutS domain III MutS_I PF01624.20 EDO14726.1 - 1.5e-31 108.9 0.0 7.5e-31 106.7 0.0 2.2 2 0 0 2 2 2 1 MutS domain I MutS_IV PF05190.18 EDO14726.1 - 1.1e-16 60.9 0.2 2.6e-16 59.7 0.2 1.7 1 0 0 1 1 1 1 MutS family domain IV MutS_II PF05188.17 EDO14726.1 - 2.8e-14 53.5 0.1 2.3e-13 50.6 0.0 2.4 2 0 0 2 2 2 1 MutS domain II AAA_29 PF13555.6 EDO14726.1 - 0.057 13.2 0.0 0.2 11.4 0.0 1.9 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_27 PF13514.6 EDO14726.1 - 0.08 12.5 0.0 0.2 11.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 EDO14726.1 - 0.21 12.1 0.1 0.21 12.1 0.1 3.3 4 0 0 4 4 4 0 AAA domain Sec63 PF02889.16 EDO14727.1 - 2.5e-140 466.0 12.5 1.5e-78 263.5 3.1 2.4 2 0 0 2 2 2 2 Sec63 Brl domain DEAD PF00270.29 EDO14727.1 - 1.7e-40 138.7 0.0 3e-26 92.3 0.0 2.7 2 0 0 2 2 2 2 DEAD/DEAH box helicase Helicase_PWI PF18149.1 EDO14727.1 - 3.7e-21 75.4 1.3 3.7e-21 75.4 1.3 2.7 2 0 0 2 2 2 1 N-terminal helicase PWI domain ResIII PF04851.15 EDO14727.1 - 6e-17 62.2 0.8 4.3e-13 49.6 0.0 3.1 3 0 0 3 3 3 2 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EDO14727.1 - 2.7e-10 40.6 0.5 4.5e-07 30.2 0.1 4.2 2 1 0 2 2 2 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 EDO14727.1 - 0.00032 21.0 0.4 0.86 9.9 0.1 3.7 2 2 0 2 2 2 2 AAA domain DBD_HTH PF18430.1 EDO14728.1 - 0.19 11.5 1.0 0.43 10.4 1.0 1.6 1 0 0 1 1 1 0 Putative DNA-binding domain ODC_AZ PF02100.17 EDO14731.1 - 1.3e-09 38.1 0.0 1.9e-09 37.5 0.0 1.3 1 0 0 1 1 1 1 Ornithine decarboxylase antizyme Arf PF00025.21 EDO14732.1 - 3e-46 157.1 0.1 3.6e-46 156.8 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EDO14732.1 - 1.7e-15 57.3 0.0 2.5e-15 56.8 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EDO14732.1 - 6.8e-15 55.0 0.0 8.4e-15 54.7 0.0 1.1 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 EDO14732.1 - 9.4e-15 54.5 0.0 1.2e-14 54.2 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 EDO14732.1 - 7e-10 38.6 0.2 3.8e-06 26.3 0.0 2.4 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.12 EDO14732.1 - 3.2e-07 29.9 0.0 4e-07 29.6 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EDO14732.1 - 9.9e-07 28.5 0.1 1.8e-05 24.4 0.1 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EDO14732.1 - 1.9e-06 27.9 0.0 3.1e-06 27.3 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EDO14732.1 - 0.073 13.0 0.1 0.37 10.7 0.0 1.9 2 0 0 2 2 2 0 RsgA GTPase AAA_18 PF13238.6 EDO14732.1 - 0.081 13.5 0.1 0.18 12.3 0.1 1.9 1 1 0 1 1 1 0 AAA domain AAA_22 PF13401.6 EDO14732.1 - 0.13 12.5 0.0 0.95 9.7 0.0 2.3 1 1 0 1 1 1 0 AAA domain Arginase PF00491.21 EDO14733.1 - 0.11 12.0 0.1 0.17 11.4 0.1 1.2 1 0 0 1 1 1 0 Arginase family EF1G PF00647.19 EDO14734.1 - 2.5e-48 162.6 0.2 4.5e-48 161.7 0.2 1.4 1 0 0 1 1 1 1 Elongation factor 1 gamma, conserved domain GST_N PF02798.20 EDO14734.1 - 1e-12 48.2 0.0 3.1e-12 46.6 0.0 1.9 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EDO14734.1 - 4e-11 43.0 1.2 5.1e-11 42.6 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EDO14734.1 - 7.9e-06 25.8 0.1 1.9e-05 24.6 0.1 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EDO14734.1 - 8.9e-05 22.8 0.0 0.00019 21.8 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EDO14734.1 - 0.0039 17.4 0.0 0.012 15.8 0.0 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 EDO14734.1 - 0.14 12.5 0.1 0.45 10.9 0.0 1.9 2 0 0 2 2 2 0 Glutathione S-transferase, N-terminal domain Catalase PF00199.19 EDO14735.1 - 4.8e-182 605.3 1.4 6.3e-182 604.9 1.4 1.1 1 0 0 1 1 1 1 Catalase Catalase-rel PF06628.12 EDO14735.1 - 5.9e-12 45.6 0.0 3.3e-11 43.2 0.0 2.2 2 0 0 2 2 2 1 Catalase-related immune-responsive Sgf11_N PF18519.1 EDO14736.1 - 1.9e-21 75.3 4.0 3.5e-21 74.5 4.0 1.5 1 0 0 1 1 1 1 SAGA-associated factor 11 N-terminal domain Sgf11 PF08209.11 EDO14736.1 - 1.7e-16 59.5 4.9 2.7e-16 58.8 4.9 1.3 1 0 0 1 1 1 1 Sgf11 (transcriptional regulation protein) zf-CpG_bind_C PF12269.8 EDO14736.1 - 0.0015 18.4 0.2 0.0015 18.4 0.2 1.1 1 0 0 1 1 1 1 CpG binding protein zinc finger C terminal domain zf_C2H2_13 PF18508.1 EDO14736.1 - 0.014 15.0 0.2 0.023 14.3 0.2 1.3 1 0 0 1 1 1 0 Zinc finger domain DUF4125 PF13526.6 EDO14736.1 - 0.028 14.0 0.1 0.034 13.8 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4125) RNHCP PF12647.7 EDO14736.1 - 0.048 13.6 0.8 0.081 12.9 0.8 1.3 1 0 0 1 1 1 0 RNHCP domain zf-C2HC_2 PF13913.6 EDO14736.1 - 0.066 13.1 1.0 0.066 13.1 1.0 1.4 2 0 0 2 2 2 0 zinc-finger of a C2HC-type CLTH PF10607.9 EDO14737.1 - 2.3e-13 50.3 1.6 2.3e-13 50.3 1.6 2.6 2 1 0 2 2 2 1 CTLH/CRA C-terminal to LisH motif domain zf-RING_UBOX PF13445.6 EDO14737.1 - 5.8e-06 26.2 2.5 9.1e-06 25.6 0.9 2.2 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_2 PF13639.6 EDO14737.1 - 0.0082 16.5 0.9 0.021 15.1 0.9 1.8 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 EDO14737.1 - 0.009 16.0 0.6 0.024 14.6 0.6 1.7 1 0 0 1 1 1 1 zinc-RING finger domain PilJ PF13675.6 EDO14737.1 - 0.09 12.8 0.2 0.16 12.0 0.2 1.4 1 0 0 1 1 1 0 Type IV pili methyl-accepting chemotaxis transducer N-term Prok-RING_4 PF14447.6 EDO14737.1 - 0.17 11.8 0.6 0.4 10.6 0.6 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 EDO14737.1 - 0.66 10.2 3.1 0.57 10.4 0.3 2.2 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING Skp1_POZ PF03931.15 EDO14738.1 - 3.2e-16 59.2 0.8 5.3e-16 58.5 0.8 1.3 1 0 0 1 1 1 1 Skp1 family, tetramerisation domain BTB PF00651.31 EDO14738.1 - 0.00011 22.4 0.2 0.0002 21.5 0.2 1.5 1 1 0 1 1 1 1 BTB/POZ domain DUF4264 PF14084.6 EDO14738.1 - 0.017 14.8 0.6 0.034 13.8 0.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4264) GMAP PF06540.11 EDO14738.1 - 0.017 15.2 0.0 0.026 14.6 0.0 1.3 1 0 0 1 1 1 0 Galanin message associated peptide (GMAP) Vps16_C PF04840.12 EDO14739.1 - 9.1e-79 264.8 10.0 1.9e-78 263.8 10.0 1.5 1 0 0 1 1 1 1 Vps16, C-terminal region Vps16_N PF04841.13 EDO14739.1 - 6.4e-76 255.7 2.0 6.4e-76 255.7 2.0 1.5 2 0 0 2 2 2 1 Vps16, N-terminal region SNARE PF05739.19 EDO14741.1 - 1.1e-14 54.2 3.9 6.6e-14 51.7 1.1 2.9 2 0 0 2 2 2 1 SNARE domain Syntaxin-5_N PF11416.8 EDO14741.1 - 1e-05 24.6 0.7 1.9e-05 23.7 0.0 1.9 2 0 0 2 2 2 1 Syntaxin-5 N-terminal, Sly1p-binding domain Syntaxin PF00804.25 EDO14741.1 - 0.00058 19.6 15.9 0.00075 19.2 0.8 3.3 2 1 1 3 3 3 2 Syntaxin Syntaxin-18_N PF10496.9 EDO14741.1 - 0.00075 19.7 3.8 0.00094 19.4 1.5 2.3 2 0 0 2 2 2 1 SNARE-complex protein Syntaxin-18 N-terminus MCPsignal PF00015.21 EDO14741.1 - 0.0087 15.9 0.3 0.0087 15.9 0.3 3.0 3 0 0 3 3 3 1 Methyl-accepting chemotaxis protein (MCP) signalling domain DUF16 PF01519.16 EDO14741.1 - 0.031 14.8 1.1 0.031 14.8 1.1 3.0 3 1 0 3 3 3 0 Protein of unknown function DUF16 UPF0242 PF06785.11 EDO14741.1 - 1 9.4 14.7 0.11 12.5 2.2 2.9 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus STN1_2 PF09170.10 EDO14741.1 - 4.6 7.4 7.0 1.4 9.1 0.2 2.7 1 1 1 3 3 3 0 CST, Suppressor of cdc thirteen homolog, complex subunit STN1 DUF2203 PF09969.9 EDO14741.1 - 6.7 7.5 10.6 23 5.8 0.1 3.4 2 1 2 4 4 4 0 Uncharacterized conserved protein (DUF2203) Snf7 PF03357.21 EDO14742.1 - 2.7e-47 160.6 19.3 2.7e-47 160.6 19.3 2.0 1 1 1 2 2 2 1 Snf7 NuA4 PF09340.10 EDO14742.1 - 0.044 13.7 1.6 0.14 12.0 1.6 1.9 1 0 0 1 1 1 0 Histone acetyltransferase subunit NuA4 DASH_Dad4 PF08650.10 EDO14742.1 - 0.35 10.9 7.2 0.068 13.2 1.3 2.5 1 1 1 2 2 2 0 DASH complex subunit Dad4 RPW8 PF05659.11 EDO14742.1 - 0.77 9.4 14.5 0.034 13.8 7.4 2.3 2 1 1 3 3 3 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 DUF1068 PF06364.12 EDO14742.1 - 7.9 6.3 10.6 5.2 6.9 2.4 2.4 1 1 0 2 2 2 0 Protein of unknown function (DUF1068) Abhydrolase_1 PF00561.20 EDO14743.1 - 6.8e-33 114.4 0.0 1e-32 113.8 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydro_lipase PF04083.16 EDO14743.1 - 4.2e-20 71.1 0.1 8.6e-20 70.1 0.1 1.6 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region Hydrolase_4 PF12146.8 EDO14743.1 - 0.00016 21.0 0.0 0.092 12.0 0.0 2.3 2 0 0 2 2 2 2 Serine aminopeptidase, S33 FSH1 PF03959.13 EDO14743.1 - 0.00062 19.5 0.0 0.29 10.7 0.0 2.2 2 0 0 2 2 2 2 Serine hydrolase (FSH1) Abhydrolase_2 PF02230.16 EDO14743.1 - 0.00079 19.3 0.0 0.24 11.2 0.0 2.4 2 0 0 2 2 2 2 Phospholipase/Carboxylesterase E1_FCCH PF16190.5 EDO14743.1 - 0.11 12.7 0.1 0.25 11.6 0.1 1.5 1 0 0 1 1 1 0 Ubiquitin-activating enzyme E1 FCCH domain Cutinase PF01083.22 EDO14743.1 - 0.15 12.0 0.0 0.26 11.2 0.0 1.3 1 0 0 1 1 1 0 Cutinase L31 PF09784.9 EDO14744.1 - 9e-43 144.9 4.6 2.2e-42 143.6 4.6 1.5 1 1 0 1 1 1 1 Mitochondrial ribosomal protein L31 Cmc1 PF08583.10 EDO14745.1 - 7.7e-20 70.7 7.2 1e-19 70.3 7.2 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like COX17 PF05051.13 EDO14745.1 - 0.026 14.9 5.7 0.81 10.1 0.7 2.2 1 1 1 2 2 2 0 Cytochrome C oxidase copper chaperone (COX17) CX9C PF16860.5 EDO14745.1 - 0.039 14.0 2.8 0.16 12.0 2.0 2.1 1 1 1 2 2 2 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, CHCH PF06747.13 EDO14745.1 - 0.23 11.6 6.2 1.1 9.5 1.0 2.3 1 1 1 2 2 2 0 CHCH domain WD40 PF00400.32 EDO14746.1 - 4.8e-46 153.8 6.5 1.4e-07 32.1 0.2 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDO14746.1 - 4.7e-11 42.8 0.6 0.036 14.4 0.0 5.2 1 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EDO14746.1 - 1.7e-06 27.3 0.2 0.15 11.0 0.0 3.7 2 1 0 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 EDO14746.1 - 4.8e-06 25.5 5.7 0.023 13.4 0.1 4.6 1 1 3 5 5 5 2 Nucleoporin Nup120/160 eIF2A PF08662.11 EDO14746.1 - 8e-06 25.9 0.4 0.00064 19.7 0.0 3.0 2 1 1 3 3 3 1 Eukaryotic translation initiation factor eIF2A Nucleoporin_N PF08801.11 EDO14746.1 - 0.028 13.2 0.8 6.3 5.4 0.1 3.7 1 1 0 3 3 3 0 Nup133 N terminal like PD40 PF07676.12 EDO14746.1 - 0.038 13.9 0.1 19 5.3 0.0 3.1 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat DUF1513 PF07433.11 EDO14746.1 - 0.053 12.6 0.1 0.96 8.5 0.0 2.5 1 1 0 2 2 2 0 Protein of unknown function (DUF1513) Peptidase_M3 PF01432.20 EDO14747.1 - 1.1e-135 453.5 0.0 1.3e-135 453.2 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M3 Minor_capsid_2 PF11114.8 EDO14747.1 - 0.11 12.5 0.0 0.24 11.4 0.0 1.5 1 0 0 1 1 1 0 Minor capsid protein Peptidase_M91 PF14891.6 EDO14747.1 - 0.13 12.6 0.0 0.26 11.6 0.0 1.4 1 0 0 1 1 1 0 Effector protein Mur_ligase_M PF08245.12 EDO14748.1 - 2.2e-08 34.3 0.1 7.1e-08 32.7 0.1 1.9 1 1 0 1 1 1 1 Mur ligase middle domain She2p PF11435.8 EDO14749.1 - 3.2e-75 252.2 3.2 4e-75 251.9 3.2 1.0 1 0 0 1 1 1 1 RNA binding protein She2p Aldedh PF00171.22 EDO14750.1 - 4.2e-69 233.2 0.0 5e-69 233.0 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family TPP_enzyme_N PF02776.18 EDO14751.1 - 3.3e-56 189.6 0.0 8.3e-56 188.3 0.0 1.7 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.21 EDO14751.1 - 1.2e-48 164.8 0.0 2.6e-47 160.5 0.0 2.5 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.22 EDO14751.1 - 6.5e-41 139.3 0.3 1.6e-40 138.0 0.3 1.7 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain CO_dh PF02552.16 EDO14751.1 - 0.078 12.8 0.0 0.16 11.7 0.0 1.5 1 0 0 1 1 1 0 CO dehydrogenase beta subunit/acetyl-CoA synthase epsilon subunit POR_N PF01855.19 EDO14751.1 - 0.13 12.0 0.0 0.24 11.1 0.0 1.4 1 0 0 1 1 1 0 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg SPG4 PF17325.2 EDO14752.1 - 1.6e-40 138.6 6.6 1.8e-40 138.4 6.6 1.0 1 0 0 1 1 1 1 Stationary phase protein 4 TAF8_C PF10406.9 EDO14752.1 - 0.1 13.2 0.5 0.2 12.3 0.5 1.5 1 0 0 1 1 1 0 Transcription factor TFIID complex subunit 8 C-term Oxysterol_BP PF01237.18 EDO14753.1 - 7.2e-85 285.0 0.6 5.1e-83 279.0 0.6 2.1 1 1 0 1 1 1 1 Oxysterol-binding protein PPI_Ypi1 PF07491.11 EDO14755.1 - 2.5e-21 75.3 12.7 1.6e-20 72.6 12.7 2.3 1 1 0 1 1 1 1 Protein phosphatase inhibitor Slp PF03843.13 EDO14755.1 - 0.086 12.2 0.0 0.13 11.6 0.0 1.3 1 0 0 1 1 1 0 Outer membrane lipoprotein Slp family DUF3859 PF12975.7 EDO14755.1 - 0.11 12.4 0.1 0.16 11.9 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3859) Dehydrin PF00257.19 EDO14755.1 - 1.5 9.4 7.5 2.7 8.5 7.5 1.6 1 1 0 1 1 1 0 Dehydrin Nic96 PF04097.14 EDO14756.1 - 4.5e-199 662.9 9.7 6.9e-199 662.3 9.7 1.2 1 0 0 1 1 1 1 Nup93/Nic96 GCIP PF13324.6 EDO14756.1 - 0.1 12.2 2.9 0.3 10.6 1.5 2.3 1 1 1 2 2 2 0 Grap2 and cyclin-D-interacting MmgE_PrpD PF03972.14 EDO14757.1 - 8.3e-145 482.7 0.0 9.9e-145 482.4 0.0 1.0 1 0 0 1 1 1 1 MmgE/PrpD family Citrate_synt PF00285.21 EDO14758.1 - 2.4e-95 319.7 0.0 2.8e-95 319.5 0.0 1.0 1 0 0 1 1 1 1 Citrate synthase, C-terminal domain Phage_cap_E PF03864.15 EDO14758.1 - 0.0089 15.2 0.0 0.013 14.7 0.0 1.1 1 0 0 1 1 1 1 Phage major capsid protein E EAP30 PF04157.16 EDO14759.1 - 1.7e-53 181.4 0.0 1.9e-53 181.2 0.0 1.0 1 0 0 1 1 1 1 EAP30/Vps36 family SPATA1_C PF15743.5 EDO14759.1 - 0.051 13.7 0.0 0.09 12.8 0.0 1.3 1 0 0 1 1 1 0 Spermatogenesis-associated C-terminus Pil1 PF13805.6 EDO14760.1 - 2.5e-123 410.8 0.3 3e-123 410.5 0.3 1.1 1 0 0 1 1 1 1 Eisosome component PIL1 PCP_red PF08369.10 EDO14760.1 - 0.019 15.2 0.2 0.49 10.6 0.1 2.5 2 0 0 2 2 2 0 Proto-chlorophyllide reductase 57 kD subunit AATF-Che1 PF13339.6 EDO14760.1 - 0.035 14.8 0.1 0.12 13.1 0.0 1.9 1 1 1 2 2 2 0 Apoptosis antagonizing transcription factor PPR_2 PF13041.6 EDO14761.1 - 4.5e-15 55.6 3.9 1.3e-06 28.5 0.0 4.3 4 1 1 5 5 5 2 PPR repeat family PPR_3 PF13812.6 EDO14761.1 - 4.2e-08 33.1 1.3 0.0024 17.9 0.0 3.1 3 0 0 3 3 3 2 Pentatricopeptide repeat domain PPR_long PF17177.4 EDO14761.1 - 0.0018 17.7 0.0 0.32 10.3 0.0 2.3 2 0 0 2 2 2 2 Pentacotripeptide-repeat region of PRORP Corona_6B_7B PF03262.13 EDO14761.1 - 0.0018 17.8 0.0 0.0043 16.5 0.0 1.6 1 0 0 1 1 1 1 Coronavirus 6B/7B protein PPR PF01535.20 EDO14761.1 - 0.021 15.1 0.5 6.1 7.3 0.0 3.8 3 0 0 3 3 3 0 PPR repeat PPR_1 PF12854.7 EDO14761.1 - 0.14 11.9 0.5 2.6 7.8 0.0 3.0 3 0 0 3 3 3 0 PPR repeat Patched PF02460.18 EDO14762.1 - 1.9e-57 195.0 29.7 3.2e-29 101.6 14.3 2.7 1 1 1 2 2 2 2 Patched family Sterol-sensing PF12349.8 EDO14762.1 - 2.6e-42 144.2 28.4 7.4e-40 136.3 9.7 2.4 2 0 0 2 2 2 2 Sterol-sensing domain of SREBP cleavage-activation DUF735 PF05246.11 EDO14762.1 - 0.01 15.8 0.8 1.7 8.6 0.1 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF735) HMW1C_N PF18071.1 EDO14762.1 - 0.11 12.3 0.7 0.29 10.9 0.7 1.7 1 0 0 1 1 1 0 HMW1C N-terminal MMPL PF03176.15 EDO14762.1 - 0.49 9.3 22.6 0.011 14.7 1.5 2.2 2 0 0 2 2 2 0 MMPL family ACR_tran PF00873.19 EDO14762.1 - 8.5 3.9 22.1 1.4 6.5 17.1 1.8 2 0 0 2 2 2 0 AcrB/AcrD/AcrF family Gti1_Pac2 PF09729.9 EDO14763.1 - 6.8e-51 172.9 3.8 6.8e-51 172.9 3.8 4.6 2 2 0 2 2 2 1 Gti1/Pac2 family Mito_carr PF00153.27 EDO14764.1 - 1.7e-73 242.6 3.5 2.8e-24 84.8 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 EDO14764.1 - 4.3e-05 22.8 0.4 0.03 13.5 0.0 3.2 3 0 0 3 3 3 2 Gammaproteobacterial serine protease Thioredoxin PF00085.20 EDO14765.1 - 1.3e-23 82.9 1.3 5.2e-20 71.4 0.0 3.7 4 0 0 4 4 4 2 Thioredoxin Thioredoxin_6 PF13848.6 EDO14765.1 - 4.1e-07 30.1 6.7 1.5e-05 25.0 2.3 2.8 2 0 0 2 2 2 2 Thioredoxin-like domain DnaGprimase_HBD PF16730.5 EDO14765.1 - 1.5 8.9 6.0 0.92 9.6 1.6 2.9 4 0 0 4 4 4 0 DnaG-primase C-terminal, helicase-binding domain DUF2207 PF09972.9 EDO14766.1 - 0.045 12.5 0.3 0.045 12.5 0.3 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) FmiP_Thoc5 PF09766.9 EDO14766.1 - 0.057 12.7 0.1 0.068 12.4 0.1 1.1 1 0 0 1 1 1 0 Fms-interacting protein/Thoc5 Sec20 PF03908.13 EDO14766.1 - 0.13 12.2 4.0 1.3 9.0 0.3 2.1 1 1 1 2 2 2 0 Sec20 MttA_Hcf106 PF02416.16 EDO14766.1 - 1.2 8.5 5.4 2.9 7.3 5.4 1.6 1 0 0 1 1 1 0 mttA/Hcf106 family Synaptobrevin PF00957.21 EDO14766.1 - 2.7 7.9 8.1 5.3 6.9 8.1 1.6 1 1 0 1 1 1 0 Synaptobrevin ParA PF10609.9 EDO14767.1 - 2.6e-97 325.1 0.0 2.9e-97 324.9 0.0 1.0 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 EDO14767.1 - 3.3e-09 36.9 0.0 1.5e-08 34.7 0.0 2.1 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 EDO14767.1 - 3.2e-08 33.7 0.2 2.9e-07 30.6 0.2 2.2 1 1 0 1 1 1 1 AAA domain MipZ PF09140.11 EDO14767.1 - 8e-07 28.6 0.0 4.9e-06 26.0 0.0 1.9 1 1 0 1 1 1 1 ATPase MipZ ArsA_ATPase PF02374.15 EDO14767.1 - 9.7e-06 25.0 0.4 8.5e-05 21.9 0.3 2.1 2 0 0 2 2 2 1 Anion-transporting ATPase MeaB PF03308.16 EDO14767.1 - 0.0047 16.0 0.1 0.0068 15.4 0.1 1.2 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB Fer4_NifH PF00142.18 EDO14767.1 - 0.02 14.4 0.1 0.38 10.2 0.0 2.2 2 0 0 2 2 2 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family AAA_25 PF13481.6 EDO14767.1 - 0.044 13.3 0.3 0.07 12.7 0.3 1.3 1 0 0 1 1 1 0 AAA domain CBP_BcsQ PF06564.12 EDO14767.1 - 0.044 13.2 0.0 0.21 11.0 0.0 1.9 1 1 0 1 1 1 0 Cellulose biosynthesis protein BcsQ APS_kinase PF01583.20 EDO14767.1 - 0.063 13.2 0.0 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 Adenylylsulphate kinase RsgA_GTPase PF03193.16 EDO14767.1 - 0.093 12.6 0.1 0.2 11.5 0.1 1.6 1 0 0 1 1 1 0 RsgA GTPase AAA_16 PF13191.6 EDO14767.1 - 0.12 12.7 0.1 0.22 11.9 0.1 1.4 1 0 0 1 1 1 0 AAA ATPase domain IstB_IS21 PF01695.17 EDO14767.1 - 0.16 11.7 0.0 0.33 10.7 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein Syja_N PF02383.18 EDO14768.1 - 3e-47 161.5 1.7 5.1e-47 160.7 1.7 1.4 1 0 0 1 1 1 1 SacI homology domain Exo_endo_phos PF03372.23 EDO14768.1 - 3.2e-08 33.4 0.0 4.9e-08 32.8 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family PMI_typeI PF01238.21 EDO14769.1 - 6.4e-151 502.8 0.1 7.7e-151 502.5 0.1 1.0 1 0 0 1 1 1 1 Phosphomannose isomerase type I AraC_binding PF02311.19 EDO14769.1 - 0.00021 21.2 0.0 0.035 14.0 0.0 2.6 2 0 0 2 2 2 1 AraC-like ligand binding domain GldH_lipo PF14109.6 EDO14769.1 - 0.015 16.0 0.0 0.027 15.3 0.0 1.3 1 0 0 1 1 1 0 GldH lipoprotein Cupin_2 PF07883.11 EDO14769.1 - 0.071 12.8 0.0 18 5.2 0.1 2.3 2 0 0 2 2 2 0 Cupin domain KxDL PF10241.9 EDO14769.1 - 0.14 12.4 0.3 0.39 11.0 0.3 1.7 1 0 0 1 1 1 0 Uncharacterized conserved protein HIM1 PF08732.10 EDO14770.1 - 1.4e-10 41.0 0.0 4.1e-08 32.9 0.0 2.2 1 1 1 2 2 2 2 HIM1 NAD_binding_10 PF13460.6 EDO14770.1 - 2.1e-06 27.8 0.0 2.8e-06 27.4 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EDO14770.1 - 0.00039 20.0 0.0 0.00074 19.0 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NmrA PF05368.13 EDO14770.1 - 0.00063 19.4 0.0 0.0018 17.9 0.0 1.7 1 1 0 1 1 1 1 NmrA-like family Phage_tail_2 PF06199.11 EDO14770.1 - 0.085 13.0 0.1 0.18 11.9 0.1 1.5 1 0 0 1 1 1 0 Phage tail tube protein GDA1_CD39 PF01150.17 EDO14771.1 - 3.3e-142 474.1 0.5 4.4e-142 473.7 0.5 1.1 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family Ppx-GppA PF02541.16 EDO14771.1 - 0.1 12.0 0.0 0.2 11.0 0.0 1.4 1 0 0 1 1 1 0 Ppx/GppA phosphatase family GN3L_Grn1 PF08701.11 EDO14772.1 - 1.4e-24 86.0 18.5 2.2e-24 85.3 18.5 1.3 1 0 0 1 1 1 1 GNL3L/Grn1 putative GTPase NINJA_B PF16136.5 EDO14772.1 - 0.34 11.3 9.4 0.44 10.9 0.3 2.2 2 0 0 2 2 2 0 Putative nuclear localisation signal PQ-loop PF04193.14 EDO14773.1 - 1.3e-10 40.9 7.1 7.4e-08 32.0 2.5 2.9 2 0 0 2 2 2 2 PQ loop repeat ARD PF03079.14 EDO14774.1 - 1.4e-45 155.3 1.6 1.6e-45 155.1 1.6 1.0 1 0 0 1 1 1 1 ARD/ARD' family Cupin_2 PF07883.11 EDO14774.1 - 4.3e-09 36.0 0.0 7.5e-09 35.2 0.0 1.4 1 0 0 1 1 1 1 Cupin domain Cupin_1 PF00190.22 EDO14774.1 - 5.3e-05 22.9 0.0 6.9e-05 22.5 0.0 1.2 1 0 0 1 1 1 1 Cupin AraC_binding PF02311.19 EDO14774.1 - 0.00032 20.6 0.0 0.00049 20.0 0.0 1.2 1 0 0 1 1 1 1 AraC-like ligand binding domain Oxidored_FMN PF00724.20 EDO14775.1 - 5.9e-123 410.5 0.0 6.8e-123 410.3 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Oxidored_FMN PF00724.20 EDO14776.1 - 5e-95 318.7 0.0 5.8e-95 318.4 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Anp1 PF03452.14 EDO14777.1 - 3.1e-113 377.6 0.0 3.1e-113 377.6 0.0 3.6 3 1 0 3 3 3 1 Anp1 UBA PF00627.31 EDO14778.1 - 1.3e-27 95.3 7.3 8.6e-14 51.1 1.8 2.7 2 0 0 2 2 2 2 UBA/TS-N domain ubiquitin PF00240.23 EDO14778.1 - 8.9e-17 60.6 0.7 2.1e-16 59.4 0.7 1.7 1 0 0 1 1 1 1 Ubiquitin family XPC-binding PF09280.11 EDO14778.1 - 4.9e-11 42.2 1.3 1.2e-10 41.0 1.3 1.6 1 0 0 1 1 1 1 XPC-binding domain Rad60-SLD PF11976.8 EDO14778.1 - 6.6e-07 29.1 0.2 3.4e-06 26.8 0.8 2.0 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_5 PF18037.1 EDO14778.1 - 1.5e-06 28.5 0.2 4.8e-06 26.8 0.2 1.8 1 0 0 1 1 1 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 EDO14778.1 - 0.00047 20.2 1.2 0.0011 19.0 0.0 2.1 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like UBA_3 PF09288.10 EDO14778.1 - 0.0044 16.8 0.2 3.6 7.5 0.0 2.8 2 0 0 2 2 2 2 Fungal ubiquitin-associated domain DUF2407 PF10302.9 EDO14778.1 - 0.0066 17.0 1.3 0.0066 17.0 1.3 2.5 2 1 0 2 2 2 1 DUF2407 ubiquitin-like domain UBA_2 PF08587.11 EDO14778.1 - 0.14 12.3 0.2 0.57 10.3 0.1 2.1 2 0 0 2 2 2 0 Ubiquitin associated domain (UBA) Pex14_N PF04695.13 EDO14778.1 - 4.4 8.0 13.9 6.6 7.4 0.4 2.2 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region ANAPC_CDC26 PF10471.9 EDO14778.1 - 7.2 7.5 18.8 0.7 10.8 3.7 3.6 3 0 0 3 3 3 0 Anaphase-promoting complex APC subunit CDC26 NAD_kinase PF01513.21 EDO14779.1 - 4.4e-78 262.4 0.0 5.4e-78 262.1 0.0 1.1 1 0 0 1 1 1 1 ATP-NAD kinase SH3_9 PF14604.6 EDO14779.1 - 0.048 13.5 0.0 0.1 12.5 0.0 1.4 1 0 0 1 1 1 0 Variant SH3 domain DAGK_cat PF00781.24 EDO14779.1 - 0.086 12.5 0.0 0.2 11.3 0.0 1.6 1 0 0 1 1 1 0 Diacylglycerol kinase catalytic domain GDA1_CD39 PF01150.17 EDO14780.1 - 1.4e-113 379.8 0.0 1.7e-113 379.5 0.0 1.1 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family Isy1 PF06246.12 EDO14781.1 - 5.8e-49 167.0 10.7 8.1e-47 159.9 10.7 2.0 1 1 0 1 1 1 1 Isy1-like splicing family DUF4861 PF16153.5 EDO14781.1 - 0.014 14.4 0.2 0.019 13.9 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4861) Clat_adaptor_s PF01217.20 EDO14781.1 - 0.042 13.8 0.0 0.11 12.5 0.0 1.6 1 0 0 1 1 1 0 Clathrin adaptor complex small chain MRP-L28 PF09812.9 EDO14781.1 - 0.061 13.4 3.6 0.34 11.0 1.9 2.5 2 0 0 2 2 2 0 Mitochondrial ribosomal protein L28 FAD_binding_2 PF00890.24 EDO14782.1 - 1.3e-67 228.7 0.0 1.6e-67 228.5 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 EDO14782.1 - 3e-12 46.8 0.0 7.4e-09 35.7 0.1 2.2 1 1 0 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EDO14782.1 - 2.5e-08 34.0 0.0 7.4e-08 32.5 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 EDO14782.1 - 2.2e-07 30.4 1.8 4.4e-06 26.1 0.1 2.3 2 0 0 2 2 2 1 Thi4 family Pyr_redox_2 PF07992.14 EDO14782.1 - 6.4e-06 25.6 0.1 4.4e-05 22.8 0.1 2.3 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EDO14782.1 - 0.00021 20.1 0.3 0.022 13.5 0.0 2.9 2 1 0 2 2 2 1 HI0933-like protein Amino_oxidase PF01593.24 EDO14782.1 - 0.00028 20.3 0.0 0.0034 16.7 0.0 2.2 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase FAD_oxidored PF12831.7 EDO14782.1 - 0.0012 18.3 0.1 0.004 16.5 0.1 1.8 1 1 0 1 1 1 1 FAD dependent oxidoreductase MCRA PF06100.11 EDO14782.1 - 0.0022 16.9 0.0 0.1 11.4 0.0 2.2 2 0 0 2 2 2 1 MCRA family FAD_binding_3 PF01494.19 EDO14782.1 - 0.01 15.1 0.2 0.015 14.5 0.2 1.2 1 0 0 1 1 1 0 FAD binding domain Lycopene_cycl PF05834.12 EDO14782.1 - 0.011 14.8 0.1 0.037 13.1 0.1 1.8 2 0 0 2 2 2 0 Lycopene cyclase protein GIDA PF01134.22 EDO14782.1 - 0.024 13.7 0.8 0.48 9.4 0.0 2.6 3 0 0 3 3 3 0 Glucose inhibited division protein A Pyr_redox_3 PF13738.6 EDO14782.1 - 0.028 13.7 0.1 0.44 9.7 0.1 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EDO14782.1 - 0.03 14.3 0.0 0.19 11.7 0.0 2.2 1 1 0 1 1 1 0 FAD-NAD(P)-binding Pyr_redox PF00070.27 EDO14782.1 - 0.072 13.7 0.0 9.2 6.9 0.0 2.6 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Zn_clus PF00172.18 EDO14784.1 - 0.00083 19.4 3.0 0.00083 19.4 3.0 1.5 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain AA_permease PF00324.21 EDO14786.1 - 1.1e-122 410.1 47.2 1.4e-122 409.7 47.2 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EDO14786.1 - 1.2e-36 126.5 46.5 1.5e-36 126.2 46.5 1.0 1 0 0 1 1 1 1 Amino acid permease MFS_1 PF07690.16 EDO14787.1 - 2.6e-08 33.2 56.2 1.4e-06 27.5 53.8 4.2 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EDO14787.1 - 0.0008 18.4 10.5 0.0008 18.4 10.5 3.9 4 1 1 5 5 5 2 Sugar (and other) transporter DUF4231 PF14015.6 EDO14787.1 - 0.3 11.6 0.1 0.3 11.6 0.1 3.6 4 0 0 4 4 4 0 Protein of unknown function (DUF4231) MFS_1 PF07690.16 EDO14789.1 - 1.2e-35 123.1 29.3 1.2e-35 123.1 29.3 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 EDO14789.1 - 0.0054 15.2 3.3 0.0082 14.6 3.3 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) OATP PF03137.20 EDO14789.1 - 0.097 10.9 15.9 0.04 12.2 8.8 3.3 1 1 1 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family Use1 PF09753.9 EDO14789.1 - 9.4 5.9 9.1 14 5.3 9.1 1.1 1 0 0 1 1 1 0 Membrane fusion protein Use1 DUF4162 PF13732.6 EDO14790.1 - 7.8e-06 26.5 15.4 3.1 8.6 0.1 9.5 3 3 6 10 10 10 2 Domain of unknown function (DUF4162) CAMP_factor PF07373.11 EDO14790.1 - 1.2e-05 25.0 31.2 1.9 8.0 0.5 6.9 1 1 7 8 8 8 7 CAMP factor (Cfa) NPV_P10 PF05531.12 EDO14790.1 - 1.5e-05 25.4 63.2 1e+02 3.5 6.0 12.7 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein DUF5460 PF17544.2 EDO14790.1 - 0.00035 19.7 7.0 2.4 7.1 0.1 4.9 1 1 5 6 6 6 3 Family of unknown function (DUF5460) CTD PF12815.7 EDO14790.1 - 0.33 11.6 14.1 2.5 8.8 0.5 4.6 3 1 1 4 4 4 0 Spt5 C-terminal nonapeptide repeat binding Spt4 DASH_Dam1 PF08653.10 EDO14790.1 - 0.38 10.6 27.8 17 5.3 0.2 11.1 6 3 8 14 14 14 0 DASH complex subunit Dam1 HAP1_N PF04849.13 EDO14790.1 - 3.6 6.7 9.0 6.6 5.8 0.1 4.0 4 0 0 4 4 4 0 HAP1 N-terminal conserved region MutS_III PF05192.18 EDO14790.1 - 4.4 7.5 8.9 1.2e+03 -0.5 8.9 3.7 1 1 0 1 1 1 0 MutS domain III MA3 PF02847.17 EDO14791.1 - 0.0014 18.6 30.7 0.19 11.7 4.2 4.3 2 2 3 5 5 5 5 MA3 domain Cas_Csd1 PF09709.10 EDO14791.1 - 0.12 11.1 39.4 0.55 8.9 10.9 3.2 1 1 1 2 2 2 0 CRISPR-associated protein (Cas_Csd1) Transglut_i_TM PF14400.6 EDO14791.1 - 0.56 10.2 28.4 2.8 8.0 4.5 4.1 1 1 3 4 4 4 0 Inactive transglutaminase fused to 7 transmembrane helices SRP54_N PF02881.19 EDO14791.1 - 0.56 10.5 14.5 20 5.5 0.7 5.6 2 2 3 6 6 6 0 SRP54-type protein, helical bundle domain DUF4883 PF16224.5 EDO14791.1 - 9.8 6.5 9.7 23 5.3 0.4 3.4 1 1 1 3 3 3 0 DOmain of unknown function (DUF4883) Cas_Csd1 PF09709.10 EDO14793.1 - 0.011 14.5 16.4 0.21 10.2 6.1 2.1 1 1 1 2 2 2 0 CRISPR-associated protein (Cas_Csd1) MA3 PF02847.17 EDO14793.1 - 0.26 11.3 12.9 2.3 8.3 2.4 2.3 1 1 0 2 2 2 0 MA3 domain Flocculin PF00624.18 EDO14794.1 - 9.6e-128 416.2 587.3 8.7e-13 48.3 11.9 202.2 145 3 57 202 202 202 33 Flocculin repeat UPF0020 PF01170.18 EDO14795.1 - 9.4e-11 41.8 0.0 2.2e-09 37.3 0.0 2.4 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 N6_Mtase PF02384.16 EDO14795.1 - 0.049 12.9 0.1 0.23 10.7 0.0 2.0 3 0 0 3 3 3 0 N-6 DNA Methylase Ras PF00071.22 EDO14796.1 - 5.6e-27 94.3 2.1 3.3e-22 78.8 0.2 2.7 2 1 1 3 3 3 2 Ras family Roc PF08477.13 EDO14796.1 - 1.4e-14 54.3 0.2 6.7e-09 36.0 0.0 2.7 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EDO14796.1 - 0.00023 20.7 0.3 0.002 17.6 0.1 2.2 2 0 0 2 2 2 1 ADP-ribosylation factor family AAA_7 PF12775.7 EDO14796.1 - 0.00026 20.6 0.1 0.00055 19.5 0.1 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region Gtr1_RagA PF04670.12 EDO14796.1 - 0.0024 17.3 2.9 0.13 11.6 0.1 2.3 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region AAA_16 PF13191.6 EDO14796.1 - 0.0061 17.0 0.0 0.011 16.1 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_5 PF07728.14 EDO14796.1 - 0.0062 16.5 0.0 0.016 15.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Serglycin PF04360.12 EDO14796.1 - 0.014 15.4 5.1 0.014 15.4 5.1 2.9 2 1 1 3 3 3 0 Serglycin AAA_22 PF13401.6 EDO14796.1 - 0.053 13.8 0.0 0.11 12.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 EDO14796.1 - 0.083 12.3 0.0 0.15 11.4 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI TsaE PF02367.17 EDO14796.1 - 0.11 12.5 0.0 0.27 11.2 0.0 1.7 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ABC_tran PF00005.27 EDO14796.1 - 0.4 11.2 6.1 1.2 9.7 0.1 2.6 2 0 0 2 2 2 0 ABC transporter TRM13 PF05206.14 EDO14797.1 - 4.3e-83 278.8 0.2 9.6e-83 277.7 0.2 1.6 1 1 0 1 1 1 1 Methyltransferase TRM13 zf-TRM13_CCCH PF11722.8 EDO14797.1 - 2e-12 46.6 4.5 4.9e-12 45.4 4.5 1.7 1 0 0 1 1 1 1 CCCH zinc finger in TRM13 protein zf-U11-48K PF05253.12 EDO14797.1 - 8.9e-12 44.6 1.7 2.9e-11 43.0 0.4 2.4 2 0 0 2 2 2 1 U11-48K-like CHHC zinc finger Methyltransf_32 PF13679.6 EDO14797.1 - 8.1e-06 25.9 0.1 1.7e-05 24.9 0.1 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDO14797.1 - 0.091 12.6 0.0 0.17 11.6 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.12 EDO14797.1 - 0.17 12.7 0.4 0.99 10.2 0.0 2.4 3 0 0 3 3 3 0 Methyltransferase domain Ldh_1_N PF00056.23 EDO14798.1 - 1e-35 122.9 0.8 1.6e-35 122.2 0.8 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.18 EDO14798.1 - 1.5e-29 103.1 0.0 7.9e-29 100.7 0.0 2.0 2 0 0 2 2 2 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Glyco_hydro_4 PF02056.16 EDO14798.1 - 0.006 16.1 0.0 0.0093 15.5 0.0 1.3 1 0 0 1 1 1 1 Family 4 glycosyl hydrolase Sec63 PF02889.16 EDO14798.1 - 0.14 11.3 0.1 0.26 10.4 0.0 1.4 2 0 0 2 2 2 0 Sec63 Brl domain Bax1-I PF01027.20 EDO14799.1 - 3.7e-36 124.9 28.1 6.7e-36 124.1 28.1 1.4 1 1 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 Ribosomal_S11 PF00411.19 EDO14800.1 - 7.5e-05 23.1 0.0 0.00015 22.1 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein S11 PHD PF00628.29 EDO14801.1 - 0.0017 18.2 1.1 0.0017 18.2 1.1 2.9 3 0 0 3 3 3 1 PHD-finger EMC3_TMCO1 PF01956.16 EDO14801.1 - 4 7.1 9.3 0.14 11.9 2.5 1.9 2 0 0 2 2 2 0 Integral membrane protein EMC3/TMCO1-like NTP_transf_2 PF01909.23 EDO14802.1 - 3e-17 62.7 0.0 3e-17 62.7 0.0 3.0 3 0 0 3 3 3 1 Nucleotidyltransferase domain PAP_assoc PF03828.19 EDO14802.1 - 1.1e-15 57.5 0.5 3.5e-15 55.9 0.0 2.2 2 0 0 2 2 2 1 Cid1 family poly A polymerase Polbeta PF18765.1 EDO14802.1 - 0.0075 16.3 1.0 0.02 15.0 0.0 2.3 2 0 0 2 2 2 1 Polymerase beta, Nucleotidyltransferase GCR1_C PF12550.8 EDO14803.1 - 8.8e-24 83.6 0.1 1.7e-23 82.7 0.1 1.5 1 0 0 1 1 1 1 Transcriptional activator of glycolytic enzymes Herpes_UL21 PF03252.13 EDO14803.1 - 0.009 14.8 0.6 0.067 11.9 0.0 2.1 2 0 0 2 2 2 1 Herpesvirus UL21 Ribosomal_S19e PF01090.19 EDO14804.1 - 1.1e-52 177.3 0.0 1.3e-52 177.2 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S19e RRM_1 PF00076.22 EDO14805.1 - 2.9e-34 116.7 1.0 1.7e-17 63.0 0.1 2.6 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EDO14805.1 - 1.2e-13 50.9 0.2 1.6e-07 31.4 0.0 3.0 2 1 0 2 2 2 2 RNA recognition motif Glyco_H_20C_C PF18088.1 EDO14805.1 - 0.0037 17.1 4.8 0.0077 16.1 4.8 1.4 1 0 0 1 1 1 1 Glycoside Hydrolase 20C C-terminal domain Nup35_RRM_2 PF14605.6 EDO14805.1 - 0.017 15.1 0.0 6.7 6.8 0.0 2.3 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif OB_RNB PF08206.11 EDO14805.1 - 0.03 14.0 0.2 12 5.7 0.0 2.6 2 0 0 2 2 2 0 Ribonuclease B OB domain MID_MedPIWI PF18296.1 EDO14805.1 - 3.7 7.3 19.7 2.2 8.0 3.8 2.3 2 0 0 2 2 2 0 MID domain of medPIWI OmpH PF03938.14 EDO14805.1 - 9.3 6.6 17.0 0.46 10.8 10.5 2.0 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) RVT_2 PF07727.14 EDO14806.1 - 1.3e-90 303.3 0.0 2e-90 302.7 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF5314 PF17241.2 EDO14806.1 - 1.1e-78 263.4 0.0 1.1e-78 263.4 0.0 1.7 2 0 0 2 2 2 1 Family of unknown function (DUF5314) rve PF00665.26 EDO14806.1 - 6.8e-21 74.7 0.0 1.7e-20 73.4 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain gag_pre-integrs PF13976.6 EDO14806.1 - 3.8e-15 55.5 0.0 2e-14 53.2 0.0 2.4 2 0 0 2 2 2 1 GAG-pre-integrase domain rve_3 PF13683.6 EDO14806.1 - 0.018 14.8 0.0 0.053 13.3 0.0 1.8 1 0 0 1 1 1 0 Integrase core domain DUF5314 PF17241.2 EDO14808.1 - 1.1e-80 269.9 0.4 1.1e-80 269.9 0.4 2.1 2 0 0 2 2 2 1 Family of unknown function (DUF5314) eIF3g PF12353.8 EDO14808.1 - 0.21 12.0 5.8 0.93 9.9 2.3 2.3 1 1 1 2 2 2 0 Eukaryotic translation initiation factor 3 subunit G DUF5314 PF17241.2 EDO14809.1 - 1e-42 146.1 0.8 1.3e-42 145.8 0.8 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5314) VID27_PH PF17747.1 EDO14809.1 - 0.025 14.9 0.1 2.4 8.5 0.0 2.7 2 1 0 2 2 2 0 VID27 PH-like domain Bromo_MP PF01573.16 EDO14810.1 - 0.072 12.4 0.0 0.097 12.0 0.0 1.1 1 0 0 1 1 1 0 Bromovirus movement protein Rtt106_N PF18215.1 EDO14812.1 - 0.059 13.1 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 Histone chaperone Rtt106 N-terminal domain SBF PF01758.16 EDO14813.1 - 1.1e-23 84.0 4.2 2.5e-23 82.8 4.2 1.5 1 0 0 1 1 1 1 Sodium Bile acid symporter family Pkr1 PF08636.10 EDO14815.1 - 1.1e-29 102.3 10.3 1.4e-29 102.0 10.3 1.1 1 0 0 1 1 1 1 ER protein Pkr1 ECSCR PF15820.5 EDO14815.1 - 0.014 15.2 0.0 0.016 15.0 0.0 1.2 1 0 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator DUF2140 PF09911.9 EDO14815.1 - 0.043 13.4 0.8 0.066 12.8 0.8 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2140) TssO PF17561.2 EDO14815.1 - 0.32 11.1 1.8 0.23 11.5 0.3 1.6 1 1 1 2 2 2 0 Type VI secretion system, TssO DUF3552 PF12072.8 EDO14816.1 - 0.0031 17.0 13.7 0.0031 17.0 13.7 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF3552) OmpH PF03938.14 EDO14816.1 - 2.7 8.3 19.9 0.43 10.9 9.2 3.2 3 0 0 3 3 3 0 Outer membrane protein (OmpH-like) HSP70 PF00012.20 EDO14817.1 - 5.9e-74 249.3 0.1 8.8e-74 248.8 0.1 1.2 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EDO14817.1 - 1.4e-09 37.3 0.0 2.2e-09 36.6 0.0 1.2 1 0 0 1 1 1 1 MreB/Mbl protein Brix PF04427.18 EDO14818.1 - 3.5e-51 174.1 4.6 6.2e-51 173.3 4.6 1.3 1 0 0 1 1 1 1 Brix domain DUF2514 PF10721.9 EDO14818.1 - 0.017 15.2 6.2 0.034 14.2 6.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2514) DUF755 PF05501.11 EDO14818.1 - 1.8 8.9 17.4 0.16 12.2 11.8 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF755) Mitoc_mL59 PF18126.1 EDO14818.1 - 3 8.2 13.3 11 6.3 13.3 1.9 1 0 0 1 1 1 0 Mitochondrial ribosomal protein mL59 FYVE PF01363.21 EDO14819.1 - 9.8e-21 73.7 6.4 9.8e-21 73.7 6.4 3.4 2 1 0 2 2 2 1 FYVE zinc finger zf-RING_2 PF13639.6 EDO14819.1 - 1.8e-07 31.4 2.7 1.8e-07 31.4 2.7 3.9 4 0 0 4 4 4 1 Ring finger domain zf-RING_11 PF17123.5 EDO14819.1 - 4.8e-05 23.0 4.0 4.8e-05 23.0 4.0 3.0 4 0 0 4 4 4 1 RING-like zinc finger zf-RING_UBOX PF13445.6 EDO14819.1 - 6.2e-05 22.9 2.4 6.2e-05 22.9 2.4 3.6 3 0 0 3 3 3 1 RING-type zinc-finger zf-C3HC4 PF00097.25 EDO14819.1 - 0.0025 17.7 1.8 0.0025 17.7 1.8 4.8 4 2 1 5 5 5 1 Zinc finger, C3HC4 type (RING finger) FANCL_C PF11793.8 EDO14819.1 - 0.0057 16.8 2.1 0.0057 16.8 2.1 3.4 5 0 0 5 5 4 1 FANCL C-terminal domain zf-ANAPC11 PF12861.7 EDO14819.1 - 0.026 14.5 0.3 0.026 14.5 0.3 2.5 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_2 PF13923.6 EDO14819.1 - 0.033 14.0 2.3 0.033 14.0 2.3 4.3 4 0 0 4 4 4 0 Zinc finger, C3HC4 type (RING finger) IBR PF01485.21 EDO14819.1 - 0.044 14.0 4.0 0.044 14.0 4.0 3.6 3 1 0 3 3 2 0 IBR domain, a half RING-finger domain zf-RING_5 PF14634.6 EDO14819.1 - 0.68 9.9 24.0 1.2 9.2 2.0 4.1 3 1 1 4 4 4 0 zinc-RING finger domain FYVE_2 PF02318.16 EDO14819.1 - 1.3 9.3 13.6 0.45 10.7 7.8 2.6 2 1 0 2 2 2 0 FYVE-type zinc finger Zn_ribbon_17 PF17120.5 EDO14819.1 - 2.8 7.6 16.0 0.069 12.8 1.0 3.0 3 0 0 3 3 3 0 Zinc-ribbon, C4HC2 type Prok-RING_4 PF14447.6 EDO14819.1 - 3.4 7.6 18.2 18 5.3 0.1 4.1 4 0 0 4 4 4 0 Prokaryotic RING finger family 4 BHD_3 PF10405.9 EDO14820.1 - 7.7e-14 51.9 0.0 1.7e-13 50.7 0.0 1.6 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 3 BHD_1 PF10403.9 EDO14820.1 - 1.9e-07 30.8 0.0 6.2e-07 29.2 0.0 2.0 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 1 Rad4 PF03835.15 EDO14820.1 - 7.3e-05 22.5 0.1 0.00022 20.9 0.1 1.8 1 0 0 1 1 1 1 Rad4 transglutaminase-like domain BHD_2 PF10404.9 EDO14820.1 - 0.0066 17.4 0.1 0.017 16.0 0.1 1.7 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 2 MaoC_dehydratas PF01575.19 EDO14821.1 - 0.0053 16.3 0.0 0.0086 15.6 0.0 1.3 1 0 0 1 1 1 1 MaoC like domain MaoC_dehydrat_N PF13452.6 EDO14821.1 - 0.04 14.1 0.0 0.32 11.1 0.0 2.2 2 0 0 2 2 2 0 N-terminal half of MaoC dehydratase Methyltransf_23 PF13489.6 EDO14822.1 - 2e-24 86.3 0.0 3.9e-24 85.3 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EDO14822.1 - 1.7e-15 57.6 0.0 4.4e-15 56.2 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDO14822.1 - 4.9e-14 52.8 0.0 1.3e-13 51.5 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDO14822.1 - 1.7e-12 47.4 0.0 3.3e-12 46.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EDO14822.1 - 2.2e-12 47.4 0.0 4.6e-12 46.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EDO14822.1 - 1.6e-11 44.0 0.0 2.8e-11 43.2 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Cyclin_N PF00134.23 EDO14823.1 - 3.4e-07 30.0 0.9 4.5e-07 29.7 0.9 1.2 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.11 EDO14823.1 - 0.0011 19.4 0.4 0.0012 19.2 0.4 1.2 1 0 0 1 1 1 1 Cyclin Scs3p PF10261.9 EDO14824.1 - 9.9e-21 74.4 16.3 5e-14 52.4 2.4 2.5 1 1 1 2 2 2 2 Inositol phospholipid synthesis and fat-storage-inducing TM PAP2 PF01569.21 EDO14824.1 - 3.3e-06 26.9 3.1 3.3e-06 26.9 3.1 2.1 2 1 0 3 3 3 1 PAP2 superfamily Orai-1 PF07856.12 EDO14824.1 - 0.00023 20.9 2.1 0.00023 20.9 2.1 1.5 2 0 0 2 2 2 1 Mediator of CRAC channel activity Ac76 PF05814.11 EDO14824.1 - 1.4 9.0 12.1 3 7.9 0.6 3.5 3 0 0 3 3 3 0 Orf76 (Ac76) SQHop_cyclase_C PF13243.6 EDO14825.1 - 1.7e-44 152.2 0.1 2.3e-43 148.5 0.0 2.1 2 0 0 2 2 2 1 Squalene-hopene cyclase C-terminal domain SQHop_cyclase_N PF13249.6 EDO14825.1 - 1e-35 123.3 0.0 2.4e-29 102.4 0.0 3.2 2 1 1 3 3 3 3 Squalene-hopene cyclase N-terminal domain Prenyltrans PF00432.21 EDO14825.1 - 3.1e-30 103.6 3.7 7.4e-12 44.8 1.2 4.7 4 0 0 4 4 4 3 Prenyltransferase and squalene oxidase repeat Pec_lyase PF09492.10 EDO14825.1 - 0.00078 18.9 0.1 0.031 13.6 0.0 3.0 2 2 1 3 3 3 1 Pectic acid lyase TED_complement PF07678.14 EDO14825.1 - 0.0012 17.9 0.1 0.0033 16.5 0.1 1.7 1 1 0 1 1 1 1 A-macroglobulin TED domain DUF4581 PF15167.6 EDO14825.1 - 0.14 12.4 0.2 1.1 9.4 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4581) Ubiq-assoc PF09145.10 EDO14826.1 - 1.7e-22 79.2 0.3 5.3e-22 77.5 0.3 1.9 1 0 0 1 1 1 1 Ubiquitin-associated TPR_1 PF00515.28 EDO14826.1 - 3.6e-05 23.4 0.6 0.041 13.7 0.0 3.0 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 EDO14826.1 - 0.0024 18.1 0.0 0.058 13.7 0.0 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 EDO14826.1 - 0.0031 17.5 0.0 0.97 9.7 0.0 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.6 EDO14826.1 - 0.0085 16.7 0.2 16 6.4 0.1 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat MIT PF04212.18 EDO14826.1 - 0.018 15.1 0.3 12 6.0 0.0 3.6 3 0 0 3 3 3 0 MIT (microtubule interacting and transport) domain DnaJ PF00226.31 EDO14826.1 - 0.034 14.3 0.1 0.12 12.6 0.1 1.9 1 0 0 1 1 1 0 DnaJ domain TPR_7 PF13176.6 EDO14826.1 - 0.056 13.5 0.0 22 5.4 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat XFP_C PF09363.10 EDO14826.1 - 0.059 12.8 0.8 0.3 10.5 0.8 2.2 2 1 0 2 2 2 0 XFP C-terminal domain TPR_11 PF13414.6 EDO14826.1 - 0.26 11.0 2.1 14 5.5 0.0 3.1 3 0 0 3 3 3 0 TPR repeat DASH_Dad4 PF08650.10 EDO14827.1 - 3.7e-33 113.3 8.8 4.1e-33 113.2 8.8 1.0 1 0 0 1 1 1 1 DASH complex subunit Dad4 NPV_P10 PF05531.12 EDO14827.1 - 0.0017 18.8 1.7 0.0021 18.5 1.7 1.2 1 0 0 1 1 1 1 Nucleopolyhedrovirus P10 protein Laminin_II PF06009.12 EDO14827.1 - 0.017 15.1 0.9 0.017 15.1 0.9 1.1 1 0 0 1 1 1 0 Laminin Domain II HU-CCDC81_bac_2 PF18175.1 EDO14827.1 - 0.02 14.8 2.1 0.028 14.3 2.1 1.5 1 1 0 1 1 1 0 CCDC81-like prokaryotic HU domain 2 Phage_GP20 PF06810.11 EDO14827.1 - 0.037 13.8 0.5 0.04 13.7 0.5 1.1 1 0 0 1 1 1 0 Phage minor structural protein GP20 T6PP_N PF18572.1 EDO14827.1 - 0.052 13.4 1.2 0.062 13.1 1.2 1.1 1 0 0 1 1 1 0 Trehalose-6-phosphate phosphatase N-terminal helical bundle domain DUF948 PF06103.11 EDO14827.1 - 0.063 13.5 0.8 0.072 13.4 0.8 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) DASH_Dad1 PF08649.10 EDO14827.1 - 0.064 13.4 4.4 0.15 12.3 4.0 1.9 1 1 0 1 1 1 0 DASH complex subunit Dad1 DUF4042 PF13251.6 EDO14827.1 - 0.08 12.6 0.1 0.093 12.4 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4042) DUF1759 PF03564.15 EDO14827.1 - 0.09 12.7 1.2 0.096 12.6 1.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1759) Gasdermin_C PF17708.1 EDO14827.1 - 0.1 12.7 0.0 0.11 12.6 0.0 1.0 1 0 0 1 1 1 0 Gasdermin PUB domain DUF4047 PF13256.6 EDO14827.1 - 0.11 12.7 2.3 0.34 11.1 2.2 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4047) PRD PF00874.20 EDO14827.1 - 0.14 12.5 2.0 0.18 12.2 2.0 1.3 1 1 0 1 1 1 0 PRD domain DASH_Dam1 PF08653.10 EDO14827.1 - 0.16 11.8 0.8 0.4 10.5 0.6 1.6 1 1 0 1 1 1 0 DASH complex subunit Dam1 Oxysterol_BP PF01237.18 EDO14828.1 - 2.1e-101 339.4 5.6 2.1e-101 339.4 5.6 2.4 2 1 0 2 2 2 1 Oxysterol-binding protein PH_8 PF15409.6 EDO14828.1 - 4.4e-32 110.2 0.8 1.3e-31 108.7 0.8 1.9 1 0 0 1 1 1 1 Pleckstrin homology domain PH PF00169.29 EDO14828.1 - 1.8e-05 25.2 1.0 1.8e-05 25.2 1.0 2.9 2 1 1 3 3 3 1 PH domain PH_3 PF14593.6 EDO14828.1 - 0.00076 19.6 1.6 0.0028 17.7 0.1 2.5 2 0 0 2 2 2 1 PH domain Serine_protease PF18405.1 EDO14828.1 - 0.019 14.2 0.0 0.037 13.2 0.0 1.4 1 0 0 1 1 1 0 Gammaproteobacterial serine protease PH_11 PF15413.6 EDO14828.1 - 9 6.8 15.4 0.43 11.0 5.2 3.7 3 1 0 3 3 3 0 Pleckstrin homology domain Rbsn PF11464.8 EDO14829.1 - 6.4e-17 61.0 2.4 1.8e-16 59.5 2.4 1.9 1 0 0 1 1 1 1 Rabenosyn Rab binding domain TPR_MLP1_2 PF07926.12 EDO14829.1 - 0.0069 16.5 1.7 0.0069 16.5 1.7 2.5 2 1 0 2 2 2 1 TPR/MLP1/MLP2-like protein DASH_Dad2 PF08654.10 EDO14829.1 - 0.021 15.2 2.4 7 7.1 0.4 3.1 2 2 0 2 2 2 0 DASH complex subunit Dad2 EutA PF06277.11 EDO14829.1 - 0.073 11.9 4.1 0.34 9.7 0.1 2.3 1 1 1 2 2 2 0 Ethanolamine utilisation protein EutA MIF4G PF02854.19 EDO14830.1 - 6.2e-37 127.3 46.0 4.7e-23 82.0 5.2 3.9 4 0 0 4 4 4 3 MIF4G domain Upf2 PF04050.14 EDO14830.1 - 1.6e-28 100.1 10.5 1.6e-28 100.1 10.5 2.5 2 0 0 2 2 2 1 Up-frameshift suppressor 2 Symplekin_C PF12295.8 EDO14830.1 - 0.022 14.8 1.5 4.6 7.3 0.1 3.5 2 1 1 3 3 3 0 Symplekin tight junction protein C terminal Nop14 PF04147.12 EDO14830.1 - 0.23 9.7 35.8 0.53 8.4 35.8 1.7 1 0 0 1 1 1 0 Nop14-like family ATP-synt_E PF05680.12 EDO14831.1 - 1.7e-19 69.9 0.3 1.8e-19 69.9 0.3 1.0 1 0 0 1 1 1 1 ATP synthase E chain PBP PF01161.20 EDO14832.1 - 4.5e-08 33.5 0.1 8.2e-08 32.6 0.1 1.4 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein H2O2_YaaD PF03883.14 EDO14832.1 - 0.072 12.6 0.1 0.12 11.9 0.1 1.4 1 0 0 1 1 1 0 Peroxide stress protein YaaA CAC1F_C PF16885.5 EDO14833.1 - 0.0034 17.1 1.0 0.0034 17.1 1.0 1.3 2 0 0 2 2 2 1 Voltage-gated calcium channel subunit alpha, C-term PspB PF06667.12 EDO14833.1 - 0.041 13.9 0.0 0.11 12.5 0.0 1.7 1 0 0 1 1 1 0 Phage shock protein B CN_hydrolase PF00795.22 EDO14834.1 - 3.4e-45 154.4 0.0 4.5e-45 154.0 0.0 1.2 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase NAD_synthase PF02540.17 EDO14834.1 - 3.6e-21 75.4 0.0 1.2e-20 73.7 0.0 1.7 1 1 0 1 1 1 1 NAD synthase SDP_N PF12278.8 EDO14834.1 - 0.048 13.8 0.0 0.1 12.7 0.0 1.5 1 0 0 1 1 1 0 Sex determination protein N terminal PTPlike_phytase PF14566.6 EDO14834.1 - 0.072 13.2 0.0 0.15 12.2 0.0 1.5 1 0 0 1 1 1 0 Inositol hexakisphosphate MAGE PF01454.19 EDO14835.1 - 5.3e-42 143.9 0.4 7.2e-42 143.5 0.4 1.2 1 0 0 1 1 1 1 MAGE family IU_nuc_hydro PF01156.19 EDO14836.1 - 6.1e-72 242.8 0.0 7.3e-72 242.5 0.0 1.0 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase p450 PF00067.22 EDO14837.1 - 4.8e-51 174.0 0.0 6.1e-51 173.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DIT1_PvcA PF05141.12 EDO14838.1 - 1.9e-98 329.3 0.0 3.6e-98 328.4 0.0 1.4 1 0 0 1 1 1 1 Pyoverdine/dityrosine biosynthesis protein Ribosomal_L13 PF00572.18 EDO14839.1 - 9.2e-46 155.2 0.1 1.2e-45 154.8 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L13 ABC_tran PF00005.27 EDO14840.1 - 6.2e-18 65.6 0.0 1.1e-17 64.8 0.0 1.5 1 0 0 1 1 1 1 ABC transporter ABC_trans_N PF14510.6 EDO14840.1 - 5.1e-17 62.3 0.0 1.1e-16 61.1 0.0 1.6 1 0 0 1 1 1 1 ABC-transporter N-terminal Cyclin_N PF00134.23 EDO14841.1 - 6.1e-37 126.2 0.3 8.4e-35 119.3 0.1 2.1 2 0 0 2 2 2 2 Cyclin, N-terminal domain Cyclin_C PF02984.19 EDO14841.1 - 1.2e-19 70.5 0.2 2.7e-19 69.4 0.0 1.6 2 0 0 2 2 2 1 Cyclin, C-terminal domain IF-2B PF01008.17 EDO14842.1 - 1.2e-84 283.8 0.0 1.5e-84 283.5 0.0 1.1 1 0 0 1 1 1 1 Initiation factor 2 subunit family NYD-SP28_assoc PF14775.6 EDO14842.1 - 0.1 12.7 0.2 0.28 11.3 0.2 1.6 1 0 0 1 1 1 0 Sperm tail C-terminal domain Staphostatin_A PF09022.10 EDO14842.1 - 0.12 12.3 0.2 0.36 10.8 0.1 1.8 2 0 0 2 2 2 0 Staphostatin A ATP-synt_S1 PF05827.12 EDO14843.1 - 0.0047 16.8 0.0 0.018 14.9 0.0 2.0 2 0 0 2 2 2 1 Vacuolar ATP synthase subunit S1 (ATP6S1) Connexin PF00029.19 EDO14843.1 - 0.0047 16.7 0.2 0.0079 16.0 0.2 1.3 1 0 0 1 1 1 1 Connexin LRRC37AB_C PF14914.6 EDO14843.1 - 0.012 15.5 2.6 0.031 14.2 2.6 1.7 1 0 0 1 1 1 0 LRRC37A/B like protein 1 C-terminal domain DUF5041 PF16444.5 EDO14843.1 - 0.019 15.2 2.2 0.043 14.1 2.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5041) RNA_pol_Rpc4 PF05132.14 EDO14843.1 - 0.062 13.7 0.6 0.088 13.2 0.6 1.2 1 0 0 1 1 1 0 RNA polymerase III RPC4 PBP1_TM PF14812.6 EDO14843.1 - 0.069 13.5 4.0 0.12 12.8 4.0 1.4 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Zip PF02535.22 EDO14843.1 - 0.087 12.0 0.1 0.13 11.4 0.1 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter DUF3169 PF11368.8 EDO14843.1 - 0.091 12.3 3.4 0.6 9.6 0.2 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF3169) CobT PF06213.12 EDO14843.1 - 0.29 10.5 10.0 0.36 10.2 10.0 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT SspB PF04386.13 EDO14843.1 - 0.63 9.9 7.9 1 9.2 7.9 1.2 1 0 0 1 1 1 0 Stringent starvation protein B CrgA PF06781.12 EDO14843.1 - 1.1 9.3 3.6 4.2 7.5 1.5 2.7 2 1 0 2 2 2 0 Cell division protein CrgA Pox_Ag35 PF03286.14 EDO14843.1 - 2.3 7.9 13.9 3.8 7.2 13.9 1.2 1 0 0 1 1 1 0 Pox virus Ag35 surface protein VMA21 PF09446.10 EDO14844.1 - 9.9e-12 44.8 14.0 5.9e-11 42.3 14.0 1.8 1 1 0 1 1 1 1 VMA21-like domain Pescadillo_N PF06732.11 EDO14845.1 - 2.5e-121 404.4 2.3 2.5e-121 404.4 2.3 2.1 2 0 0 2 2 2 1 Pescadillo N-terminus BRCT_2 PF16589.5 EDO14845.1 - 8.6e-10 38.9 0.0 2.4e-09 37.5 0.0 1.8 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 EDO14845.1 - 9.3e-05 22.7 0.0 0.00032 21.0 0.0 2.0 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain Usp PF00582.26 EDO14845.1 - 2.8 8.5 7.0 4.6 7.8 5.9 2.0 1 1 0 1 1 1 0 Universal stress protein family Orthopox_F14 PF06076.12 EDO14846.1 - 0.011 16.0 2.2 1 9.7 0.1 2.3 1 1 0 2 2 2 0 Orthopoxvirus F14 protein HTH_Tnp_Tc3_2 PF01498.18 EDO14846.1 - 0.12 12.7 0.0 26 5.1 0.0 2.5 2 1 0 2 2 2 0 Transposase Rhomboid PF01694.22 EDO14847.1 - 2.3e-30 105.6 18.5 2.3e-30 105.6 18.5 1.5 2 0 0 2 2 2 1 Rhomboid family Romo1 PF10247.9 EDO14847.1 - 0.4 11.1 4.3 0.69 10.3 0.2 3.1 4 0 0 4 4 4 0 Reactive mitochondrial oxygen species modulator 1 RabGAP-TBC PF00566.18 EDO14848.1 - 6.5e-52 176.3 0.2 6.5e-52 176.3 0.2 2.2 2 1 1 3 3 3 1 Rab-GTPase-TBC domain GRAM PF02893.20 EDO14848.1 - 1.2e-19 70.3 0.4 3.6e-19 68.7 0.4 1.9 1 0 0 1 1 1 1 GRAM domain EF-hand_6 PF13405.6 EDO14848.1 - 7e-06 25.6 7.4 0.00037 20.2 0.1 3.6 4 0 0 4 4 4 2 EF-hand domain EF-hand_1 PF00036.32 EDO14848.1 - 7.9e-06 25.1 0.2 0.0084 15.6 0.0 3.0 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 EDO14848.1 - 1.9e-05 25.0 2.3 0.0002 21.7 0.4 3.3 2 1 2 4 4 4 3 EF-hand domain pair BNIP3 PF06553.12 EDO14848.1 - 0.092 12.4 1.1 0.16 11.6 0.2 1.8 2 0 0 2 2 2 0 BNIP3 PH_TFIIH PF08567.11 EDO14848.1 - 0.099 13.0 0.0 0.33 11.3 0.0 1.9 1 0 0 1 1 1 0 TFIIH p62 subunit, N-terminal domain Telomere_reg-2 PF10193.9 EDO14849.1 - 2e-23 82.9 2.7 4.2e-23 81.9 0.8 2.5 2 0 0 2 2 2 1 Telomere length regulation protein DUF1948 PF09185.10 EDO14849.1 - 0.7 9.8 5.8 0.3 11.0 1.9 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF1948) Flavin_Reduct PF01613.18 EDO14850.1 - 1.6e-31 109.4 0.0 1.9e-31 109.2 0.0 1.1 1 0 0 1 1 1 1 Flavin reductase like domain TRAM_LAG1_CLN8 PF03798.16 EDO14852.1 - 3.4e-35 121.6 23.5 3.4e-35 121.6 23.5 1.6 2 0 0 2 2 2 1 TLC domain Baculo_VP91_N PF08475.10 EDO14852.1 - 0.3 10.7 3.4 0.51 10.0 3.4 1.3 1 0 0 1 1 1 0 Viral capsid protein 91 N-terminal CDP-OH_P_transf PF01066.21 EDO14853.1 - 9.2e-13 48.8 0.3 9.2e-13 48.8 0.3 2.6 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase CBM_21 PF03370.13 EDO14854.1 - 6.3e-25 87.5 11.1 6.3e-25 87.5 11.1 2.4 2 0 0 2 2 2 1 Carbohydrate/starch-binding module (family 21) Fungal_trans PF04082.18 EDO14855.1 - 6.6e-14 51.6 3.4 6.6e-14 51.6 3.4 2.9 3 0 0 3 3 3 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDO14855.1 - 8.2e-05 22.6 10.8 0.00017 21.6 10.8 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Csm1_B PF18211.1 EDO14855.1 - 0.032 14.1 0.0 0.1 12.4 0.0 1.9 1 0 0 1 1 1 0 Csm1 subunit domain B ECH_1 PF00378.20 EDO14856.1 - 4e-16 59.1 0.0 1.5e-15 57.2 0.0 1.7 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EDO14856.1 - 4.8e-06 26.3 0.0 6.4e-06 25.9 0.0 1.3 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Init_tRNA_PT PF04179.12 EDO14856.1 - 0.0047 17.2 0.6 0.017 15.4 0.6 2.0 1 1 0 1 1 1 1 Rit1 DUSP-like domain RF-1 PF00472.20 EDO14857.1 - 1.2e-18 67.1 9.7 2.2e-18 66.3 9.7 1.5 1 1 0 1 1 1 1 RF-1 domain LMBR1 PF04791.16 EDO14857.1 - 2.3 7.1 3.8 2.2 7.1 3.8 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein IBN_N PF03810.19 EDO14858.1 - 5.9e-16 58.1 1.8 1.3e-15 57.1 0.2 2.5 2 0 0 2 2 2 1 Importin-beta N-terminal domain Vac14_Fab1_bd PF12755.7 EDO14858.1 - 0.0026 18.3 2.2 0.29 11.7 0.1 4.5 4 1 0 5 5 5 1 Vacuolar 14 Fab1-binding region Rep_3 PF01051.21 EDO14858.1 - 0.015 15.1 0.3 0.058 13.2 0.3 2.1 1 0 0 1 1 1 0 Initiator Replication protein Utp12 PF04003.12 EDO14859.1 - 4.9e-23 81.5 3.6 8.3e-23 80.8 3.6 1.4 1 0 0 1 1 1 1 Dip2/Utp12 Family eIF2A PF08662.11 EDO14859.1 - 0.087 12.7 6.4 1.5 8.7 0.4 3.1 2 1 1 3 3 3 0 Eukaryotic translation initiation factor eIF2A Pribosyltran PF00156.27 EDO14860.1 - 1e-07 31.6 0.0 1.9e-07 30.8 0.0 1.3 1 0 0 1 1 1 1 Phosphoribosyl transferase domain 3Beta_HSD PF01073.19 EDO14860.1 - 0.013 14.5 0.0 0.016 14.2 0.0 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Fe-ADH PF00465.19 EDO14860.1 - 0.14 11.0 0.0 0.21 10.4 0.0 1.3 1 0 0 1 1 1 0 Iron-containing alcohol dehydrogenase DUF3982 PF13138.6 EDO14860.1 - 1.2 9.1 3.7 9.7 6.1 0.7 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3982) ISN1 PF06437.11 EDO14861.1 - 1.6e-164 547.7 0.0 2e-164 547.4 0.0 1.0 1 0 0 1 1 1 1 IMP-specific 5'-nucleotidase Formyl_trans_N PF00551.19 EDO14863.1 - 7.2e-55 185.5 0.0 8.6e-55 185.3 0.0 1.0 1 0 0 1 1 1 1 Formyl transferase PINIT PF14324.6 EDO14864.1 - 1.1e-28 100.4 0.1 2.7e-28 99.2 0.1 1.7 1 0 0 1 1 1 1 PINIT domain zf-MIZ PF02891.20 EDO14864.1 - 4.8e-20 71.0 5.8 9.7e-20 70.1 5.8 1.5 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger zf-Nse PF11789.8 EDO14864.1 - 7.5e-06 25.7 0.5 2e-05 24.3 0.5 1.7 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-C3HC4_2 PF13923.6 EDO14864.1 - 0.044 13.6 3.2 0.17 11.7 3.3 2.1 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EDO14864.1 - 0.049 13.7 3.1 0.13 12.3 3.1 1.8 1 0 0 1 1 1 0 RING-type zinc-finger zf-HIT PF04438.16 EDO14865.1 - 0.0043 16.9 5.2 0.0081 16.0 5.2 1.5 1 0 0 1 1 1 1 HIT zinc finger mIF3 PF14877.6 EDO14865.1 - 0.0098 15.6 0.5 0.015 15.0 0.5 1.3 1 0 0 1 1 1 1 Mitochondrial translation initiation factor DER1 PF04511.15 EDO14866.1 - 2.4e-40 138.5 8.5 3.1e-40 138.2 8.5 1.1 1 0 0 1 1 1 1 Der1-like family Nop25 PF09805.9 EDO14867.1 - 9.4e-37 126.5 27.6 9.4e-37 126.5 27.6 2.3 2 0 0 2 2 2 1 Nucleolar protein 12 (25kDa) EXS PF03124.14 EDO14868.1 - 1.1e-55 189.3 26.7 1.3e-55 189.1 26.7 1.0 1 0 0 1 1 1 1 EXS family Ribosomal_L2_C PF03947.18 EDO14869.1 - 1.8e-51 173.6 3.5 3.2e-51 172.8 3.5 1.4 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 EDO14869.1 - 1.1e-26 92.6 0.2 3.6e-26 90.9 0.1 1.9 2 0 0 2 2 2 1 Ribosomal Proteins L2, RNA binding domain Peptidase_M28 PF04389.17 EDO14870.1 - 2.2e-30 105.8 0.0 2.9e-30 105.4 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.28 EDO14870.1 - 2.1e-05 24.3 0.0 3.4e-05 23.6 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 ATP-synt_D PF01813.17 EDO14871.1 - 7.9e-72 241.2 4.4 7.9e-72 241.2 4.4 1.5 2 0 0 2 2 2 1 ATP synthase subunit D VHP PF02209.19 EDO14871.1 - 0.13 12.3 0.9 0.28 11.3 0.9 1.5 1 0 0 1 1 1 0 Villin headpiece domain Sec62 PF03839.16 EDO14871.1 - 7.7 6.0 7.2 14 5.1 7.2 1.4 1 0 0 1 1 1 0 Translocation protein Sec62 Vfa1 PF08432.10 EDO14871.1 - 8.6 6.7 13.9 13 6.1 8.8 2.2 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 AFG1_ATPase PF03969.16 EDO14872.1 - 4e-74 249.7 0.0 8.8e-69 232.1 0.0 3.1 2 1 0 2 2 2 2 AFG1-like ATPase AAA_16 PF13191.6 EDO14872.1 - 9.7e-05 22.8 0.2 0.0096 16.3 0.2 2.4 1 1 0 1 1 1 1 AAA ATPase domain AAA PF00004.29 EDO14872.1 - 0.0088 16.5 0.0 0.087 13.2 0.1 2.5 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EDO14872.1 - 0.009 16.3 0.1 0.03 14.6 0.1 1.9 1 1 0 1 1 1 1 AAA domain ATPase_2 PF01637.18 EDO14872.1 - 0.011 15.7 0.0 0.02 14.8 0.0 1.5 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea RNA_helicase PF00910.22 EDO14872.1 - 0.028 14.8 0.0 0.1 13.0 0.0 2.0 2 0 0 2 2 2 0 RNA helicase Bac_DnaA PF00308.18 EDO14872.1 - 0.037 13.9 0.5 0.31 10.8 0.1 2.4 2 1 0 2 2 2 0 Bacterial dnaA protein TsaE PF02367.17 EDO14872.1 - 0.044 13.8 0.0 0.1 12.6 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Ribosomal_L11_N PF03946.14 EDO14873.1 - 6.9e-22 77.1 0.6 1.9e-21 75.7 0.3 1.8 2 0 0 2 2 2 1 Ribosomal protein L11, N-terminal domain Ribosomal_L11 PF00298.19 EDO14873.1 - 2.1e-15 57.0 0.6 5.6e-15 55.6 0.1 1.8 2 0 0 2 2 2 1 Ribosomal protein L11, RNA binding domain HSP70 PF00012.20 EDO14874.1 - 1.7e-265 881.9 15.6 2e-265 881.7 15.6 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EDO14874.1 - 8.6e-15 54.4 3.6 8.4e-13 47.8 0.9 2.4 2 0 0 2 2 2 2 MreB/Mbl protein FGGY_C PF02782.16 EDO14874.1 - 0.00082 19.2 0.0 0.0025 17.6 0.0 1.8 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain DUF5321 PF17254.2 EDO14874.1 - 0.0069 15.8 0.7 0.0069 15.8 0.7 2.5 2 1 1 3 3 3 1 Family of unknown function (DUF5321) Syntaxin_2 PF14523.6 EDO14874.1 - 0.085 13.2 3.1 0.24 11.8 3.1 1.8 1 0 0 1 1 1 0 Syntaxin-like protein FtsA PF14450.6 EDO14874.1 - 0.31 11.5 9.7 1.7 9.1 0.5 4.1 3 2 0 3 3 3 0 Cell division protein FtsA DUF16 PF01519.16 EDO14874.1 - 0.52 10.8 6.4 1.5 9.3 6.4 1.9 1 0 0 1 1 1 0 Protein of unknown function DUF16 YlbD_coat PF14071.6 EDO14874.1 - 0.82 9.9 5.6 1.9 8.8 5.6 1.5 1 0 0 1 1 1 0 Putative coat protein CDT1_C PF16679.5 EDO14875.1 - 0.0086 16.5 0.1 0.02 15.3 0.1 1.6 1 0 0 1 1 1 1 DNA replication factor Cdt1 C-terminal domain CDT1 PF08839.11 EDO14875.1 - 0.034 14.5 6.6 0.68 10.2 7.4 2.5 2 1 0 2 2 2 0 DNA replication factor CDT1 like DUF1691 PF07950.11 EDO14876.1 - 2.7e-29 102.0 3.1 9e-16 58.5 0.1 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF1691) PHD PF00628.29 EDO14877.1 - 1.5e-11 44.0 7.0 1.5e-11 44.0 7.0 2.0 2 0 0 2 2 2 1 PHD-finger DisA-linker PF10635.9 EDO14877.1 - 0.027 14.3 0.4 0.61 9.8 0.1 2.4 2 0 0 2 2 2 0 DisA bacterial checkpoint controller linker region CxC6 PF18721.1 EDO14877.1 - 0.28 11.5 7.0 0.061 13.6 1.9 2.4 2 0 0 2 2 2 0 CxC6 like cysteine cluster associated with KDZ transposases Pkinase PF00069.25 EDO14878.1 - 3.2e-65 220.1 0.0 4.6e-65 219.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO14878.1 - 1.6e-38 132.5 0.0 2.5e-38 131.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDO14878.1 - 6.7e-09 35.5 0.0 1.1e-08 34.8 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 EDO14878.1 - 0.0016 18.4 0.1 0.044 13.7 0.2 2.1 1 1 0 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.22 EDO14878.1 - 0.12 11.9 0.0 0.26 10.9 0.0 1.6 1 0 0 1 1 1 0 RIO1 family Oxysterol_BP PF01237.18 EDO14879.1 - 3.2e-58 197.4 3.4 6e-56 189.9 3.4 2.1 1 1 0 1 1 1 1 Oxysterol-binding protein Nop53 PF07767.11 EDO14880.1 - 5.1e-97 325.8 49.9 5.9e-97 325.6 49.9 1.0 1 0 0 1 1 1 1 Nop53 (60S ribosomal biogenesis) DDHD PF02862.17 EDO14880.1 - 7 6.7 15.0 0.12 12.5 5.8 2.2 2 0 0 2 2 2 0 DDHD domain ABC_tran PF00005.27 EDO14881.1 - 3.4e-11 43.8 0.0 1.7e-10 41.5 0.0 2.1 2 1 0 2 2 2 1 ABC transporter SMC_N PF02463.19 EDO14881.1 - 0.012 15.0 0.0 0.018 14.5 0.0 1.5 1 1 0 1 1 1 0 RecF/RecN/SMC N terminal domain SbcCD_C PF13558.6 EDO14881.1 - 0.017 15.3 0.2 0.28 11.5 0.2 2.3 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit Ntox28 PF15605.6 EDO14881.1 - 0.084 13.1 0.1 0.21 11.8 0.1 1.7 2 0 0 2 2 2 0 Bacterial toxin 28 APG5 PF04106.12 EDO14882.1 - 1.5e-47 162.1 1.4 2e-47 161.7 1.4 1.1 1 0 0 1 1 1 1 Autophagy protein Apg5 Pribosyl_synth PF14572.6 EDO14883.1 - 5e-41 140.7 2.2 1.5e-35 122.9 1.3 2.2 1 1 1 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran_N PF13793.6 EDO14883.1 - 8.5e-39 132.1 0.2 2.6e-38 130.5 0.0 1.8 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyltran PF00156.27 EDO14883.1 - 1.9e-16 60.0 0.5 5.8e-16 58.4 0.4 1.8 2 0 0 2 2 2 1 Phosphoribosyl transferase domain UPRTase PF14681.6 EDO14883.1 - 0.021 14.3 0.1 0.041 13.3 0.1 1.5 1 0 0 1 1 1 0 Uracil phosphoribosyltransferase HAD_2 PF13419.6 EDO14884.1 - 1.9e-22 80.2 0.0 2.5e-22 79.8 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EDO14884.1 - 2.4e-14 54.1 0.0 7.1e-12 46.1 0.0 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 EDO14884.1 - 2e-05 24.6 0.0 0.0044 17.1 0.0 2.3 2 0 0 2 2 2 2 Haloacid dehalogenase-like hydrolase HAD PF12710.7 EDO14884.1 - 0.0061 17.0 0.0 0.011 16.2 0.0 1.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Ribosomal_S10 PF00338.22 EDO14885.1 - 7.6e-24 83.8 1.0 9.1e-24 83.5 1.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e QRPTase_C PF01729.19 EDO14886.1 - 3.5e-59 199.3 0.0 4.3e-59 199.1 0.0 1.1 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, C-terminal domain QRPTase_N PF02749.16 EDO14886.1 - 1.4e-17 63.6 0.0 3.5e-17 62.2 0.0 1.7 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, N-terminal domain Chordopox_A15 PF05846.12 EDO14886.1 - 0.029 14.6 0.0 0.078 13.2 0.0 1.7 2 0 0 2 2 2 0 Chordopoxvirus A15 protein IBN_N PF03810.19 EDO14887.1 - 5.9e-08 32.5 0.3 7.1e-07 29.1 0.0 3.0 3 0 0 3 3 3 1 Importin-beta N-terminal domain DUF656 PF04920.12 EDO14887.1 - 0.038 13.9 0.2 0.4 10.6 0.0 2.7 3 0 0 3 3 3 0 Family of unknown function (DUF656) Xpo1 PF08389.12 EDO14887.1 - 1.8 8.6 18.1 0.71 9.9 0.0 5.3 4 2 1 5 5 5 0 Exportin 1-like protein A_deamin PF02137.18 EDO14888.1 - 4.2e-29 102.0 0.1 6.9e-29 101.3 0.1 1.3 1 1 0 1 1 1 1 Adenosine-deaminase (editase) domain GerD PF17898.1 EDO14888.1 - 0.016 15.2 0.3 0.049 13.6 0.3 1.8 2 0 0 2 2 2 0 Spore germination GerD central core domain RAI1 PF08652.11 EDO14889.1 - 4.1e-27 94.2 0.1 8.3e-27 93.2 0.1 1.5 1 0 0 1 1 1 1 RAI1 like PD-(D/E)XK nuclease DUF3848 PF12959.7 EDO14889.1 - 0.12 12.5 0.1 0.42 10.7 0.1 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3848) Brr6_like_C_C PF10104.9 EDO14890.1 - 1.8e-41 141.0 5.2 2.2e-41 140.8 5.2 1.1 1 0 0 1 1 1 1 Di-sulfide bridge nucleocytoplasmic transport domain S36_mt PF10937.8 EDO14891.1 - 3.2e-28 99.6 0.0 3.9e-28 99.4 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S36, mitochondrial PDEase_II PF02112.15 EDO14892.1 - 2.9e-62 210.7 0.0 3.8e-62 210.4 0.0 1.1 1 0 0 1 1 1 1 cAMP phosphodiesterases class-II Proteasome PF00227.26 EDO14893.1 - 2.4e-24 85.9 0.1 3.1e-24 85.5 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit DUF3192 PF11399.8 EDO14893.1 - 0.052 13.5 0.0 0.096 12.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3192) Adap_comp_sub PF00928.21 EDO14894.1 - 6.3e-12 45.4 1.2 9.8e-12 44.8 1.2 1.3 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 EDO14894.1 - 3.9e-08 33.3 2.0 3.9e-08 33.3 2.0 2.0 2 0 0 2 2 2 1 Clathrin adaptor complex small chain CDC37_N PF03234.14 EDO14894.1 - 0.35 11.8 0.1 0.35 11.8 0.1 2.7 2 0 0 2 2 2 0 Cdc37 N terminal kinase binding Peptidase_M1 PF01433.20 EDO14895.1 - 2.3e-71 239.8 0.1 5.6e-71 238.6 0.1 1.7 1 0 0 1 1 1 1 Peptidase family M1 domain Peptidase_M1_N PF17900.1 EDO14895.1 - 2e-48 165.0 3.1 7e-48 163.3 0.8 2.2 2 0 0 2 2 2 1 Peptidase M1 N-terminal domain ERAP1_C PF11838.8 EDO14895.1 - 4e-38 131.7 0.5 4e-38 131.7 0.5 1.7 2 0 0 2 2 2 1 ERAP1-like C-terminal domain Glyco_transf_15 PF01793.16 EDO14898.1 - 9.8e-115 383.2 19.0 1.4e-114 382.7 19.0 1.2 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase Ribosomal_L32e PF01655.18 EDO14898.1 - 0.042 14.3 0.0 0.11 12.9 0.0 1.7 1 0 0 1 1 1 0 Ribosomal protein L32 adh_short PF00106.25 EDO14899.1 - 5.2e-86 287.1 14.1 2.4e-44 151.2 3.7 2.8 2 1 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EDO14899.1 - 5.1e-70 235.7 8.3 2.3e-39 135.3 1.5 3.5 3 1 0 3 3 3 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EDO14899.1 - 1.3e-33 116.4 3.0 5e-16 59.1 0.4 2.3 2 0 0 2 2 2 2 KR domain MaoC_dehydratas PF01575.19 EDO14899.1 - 2.1e-33 114.5 0.0 4.2e-33 113.5 0.0 1.5 1 0 0 1 1 1 1 MaoC like domain MaoC_dehydrat_N PF13452.6 EDO14899.1 - 0.0017 18.5 0.0 0.48 10.6 0.0 2.7 2 0 0 2 2 2 1 N-terminal half of MaoC dehydratase DUF1776 PF08643.10 EDO14899.1 - 0.021 14.2 0.0 0.051 12.9 0.0 1.6 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) AdoHcyase_NAD PF00670.21 EDO14899.1 - 0.033 14.3 0.3 0.033 14.3 0.3 2.4 2 0 0 2 2 2 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 3HCDH_N PF02737.18 EDO14899.1 - 0.19 11.6 3.5 0.69 9.8 0.2 2.5 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_7 PF13241.6 EDO14899.1 - 0.32 11.5 4.2 3.4 8.1 0.1 3.9 5 0 0 5 5 5 0 Putative NAD(P)-binding PglL_A PF15864.5 EDO14899.1 - 6.4 6.6 6.2 5.5 6.8 1.0 2.5 2 0 0 2 2 2 0 Protein glycosylation ligase Mito_carr PF00153.27 EDO14900.1 - 3.3e-56 187.2 3.9 2.7e-21 75.3 0.2 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Tim17 PF02466.19 EDO14900.1 - 0.56 10.6 4.5 4.7 7.6 1.0 3.2 1 1 2 3 3 3 0 Tim17/Tim22/Tim23/Pmp24 family Mito_carr PF00153.27 EDO14901.1 - 3.5e-61 203.1 1.4 1.1e-22 79.7 0.0 3.5 3 1 0 3 3 3 3 Mitochondrial carrier protein TFIIE_alpha PF02002.17 EDO14902.1 - 2e-32 111.2 1.9 5.9e-32 109.7 0.0 2.6 3 0 0 3 3 3 1 TFIIE alpha subunit TF_Zn_Ribbon PF08271.12 EDO14902.1 - 3.3e-11 42.5 0.4 1.2e-10 40.7 0.4 2.1 1 0 0 1 1 1 1 TFIIB zinc-binding Malic_M PF03949.15 EDO14903.1 - 2.2e-88 295.8 0.0 3.3e-88 295.3 0.0 1.3 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.19 EDO14903.1 - 7.3e-64 214.9 0.0 1.2e-63 214.2 0.0 1.4 1 0 0 1 1 1 1 Malic enzyme, N-terminal domain NIF PF03031.18 EDO14904.1 - 2.2e-47 160.7 0.6 3.3e-46 156.9 0.6 2.3 1 1 0 1 1 1 1 NLI interacting factor-like phosphatase Apc15p PF05841.11 EDO14904.1 - 0.16 12.8 6.9 0.42 11.4 3.7 2.3 2 0 0 2 2 2 0 Apc15p protein Orf78 PF06024.12 EDO14904.1 - 0.94 9.8 7.0 6.6 7.1 4.4 2.5 2 0 0 2 2 2 0 Orf78 (ac78) Cg6151-P PF10233.9 EDO14905.1 - 6.8e-36 123.0 15.2 7.8e-36 122.8 15.2 1.0 1 0 0 1 1 1 1 Uncharacterized conserved protein CG6151-P TMEM72 PF16054.5 EDO14905.1 - 0.00079 19.2 2.6 0.0011 18.7 2.6 1.2 1 0 0 1 1 1 1 Transmembrane protein family 72 DUF308 PF03729.13 EDO14905.1 - 0.0059 16.9 0.7 0.0059 16.9 0.7 2.6 2 1 0 2 2 2 1 Short repeat of unknown function (DUF308) Chordopox_A13L PF05961.11 EDO14905.1 - 0.03 14.6 0.0 0.03 14.6 0.0 1.7 2 0 0 2 2 2 0 Chordopoxvirus A13L protein Phage_holin_T PF11031.8 EDO14905.1 - 0.051 13.1 0.7 3.1 7.2 0.1 2.0 1 1 1 2 2 2 0 Bacteriophage T holin Phage_holin_3_6 PF07332.11 EDO14905.1 - 0.9 9.6 4.9 0.39 10.8 0.2 1.9 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III DUF3556 PF12077.8 EDO14906.1 - 0.018 13.5 1.6 0.024 13.1 1.6 1.1 1 0 0 1 1 1 0 Transmembrane protein of unknown function (DUF3556) SR-25 PF10500.9 EDO14906.1 - 1.2 8.7 15.6 1.9 8.0 7.9 2.2 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Macoilin PF09726.9 EDO14906.1 - 1.6 7.2 7.8 2.6 6.5 7.8 1.3 1 0 0 1 1 1 0 Macoilin family Apc15p PF05841.11 EDO14906.1 - 4.8 8.0 9.0 1.3 9.9 3.9 2.1 2 0 0 2 2 2 0 Apc15p protein HMG_box PF00505.19 EDO14907.1 - 1.6e-33 114.9 6.1 4.3e-19 68.7 2.1 2.9 2 0 0 2 2 2 2 HMG (high mobility group) box HMG_box_2 PF09011.10 EDO14907.1 - 1.3e-15 57.8 11.3 2.5e-10 40.8 1.3 3.3 3 0 0 3 3 3 2 HMG-box domain CHDNT PF08073.12 EDO14907.1 - 4.5e-10 39.3 0.0 3.1e-05 23.8 0.0 2.7 2 0 0 2 2 2 2 CHDNT (NUC034) domain Dapper PF15268.6 EDO14907.1 - 1 8.2 42.2 1.3 7.8 42.2 1.1 1 0 0 1 1 1 0 Dapper Cyt-b5 PF00173.28 EDO14908.1 - 1.9e-19 69.6 0.0 3.8e-19 68.6 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Form_Nir_trans PF01226.17 EDO14909.1 - 4.3e-56 189.9 20.6 5.5e-56 189.5 20.6 1.1 1 0 0 1 1 1 1 Formate/nitrite transporter Vac14_Fab1_bd PF12755.7 EDO14910.1 - 0.0068 17.0 3.1 1.1 9.9 0.0 4.6 4 0 0 4 4 4 1 Vacuolar 14 Fab1-binding region C2 PF00168.30 EDO14912.1 - 0.99 9.7 6.0 4.1e+02 1.3 0.0 5.2 2 1 8 10 10 10 0 C2 domain DUF5092 PF17010.5 EDO14913.1 - 1.4 8.8 12.1 2.1e+02 1.8 0.1 8.7 2 1 7 10 10 10 0 Domain of unknown function (DUF5092) C2 PF00168.30 EDO14913.1 - 4.5 7.6 38.0 2.6e+02 1.9 0.1 17.6 2 2 19 27 27 27 0 C2 domain Pih1_fungal_CS PF18482.1 EDO14914.1 - 7.9e-32 109.6 6.0 1.6e-31 108.7 6.0 1.5 1 0 0 1 1 1 1 Fungal Pih1 CS domain PIH1 PF08190.12 EDO14914.1 - 1.2e-13 50.9 0.2 2.7e-13 49.7 0.2 1.6 1 0 0 1 1 1 1 PIH1 N-terminal domain Zn_clus PF00172.18 EDO14915.1 - 2.6e-07 30.7 5.3 4.4e-07 29.9 5.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain HIT PF01230.23 EDO14916.1 - 2.7e-24 85.8 0.4 5.3e-24 84.8 0.1 1.6 2 0 0 2 2 2 1 HIT domain DcpS_C PF11969.8 EDO14916.1 - 3.4e-06 27.5 0.1 6.1e-06 26.7 0.1 1.4 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding NAT PF04768.13 EDO14916.1 - 0.012 15.2 0.2 0.023 14.3 0.2 1.6 1 1 0 1 1 1 0 NAT, N-acetyltransferase, of N-acetylglutamate synthase Med21 PF11221.8 EDO14917.1 - 1.2e-42 145.5 6.0 1.8e-42 145.0 6.0 1.2 1 0 0 1 1 1 1 Subunit 21 of Mediator complex Med9 PF07544.13 EDO14917.1 - 0.0044 17.1 3.9 0.038 14.1 3.9 2.3 1 1 0 1 1 1 1 RNA polymerase II transcription mediator complex subunit 9 ApbA_C PF08546.11 EDO14920.1 - 9.5e-32 109.8 0.1 1.4e-31 109.3 0.1 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal ApbA PF02558.16 EDO14920.1 - 5.7e-31 107.2 0.0 8.6e-31 106.6 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA Cucumopine_C PF18631.1 EDO14920.1 - 0.11 12.4 0.0 0.22 11.5 0.0 1.5 1 0 0 1 1 1 0 Cucumopine synthase C-terminal helical bundle domain HSP70 PF00012.20 EDO14921.1 - 6.4e-75 252.5 0.4 6.4e-75 252.5 0.4 1.4 1 1 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EDO14921.1 - 1e-08 34.4 0.0 1.7e-08 33.7 0.0 1.2 1 0 0 1 1 1 1 MreB/Mbl protein BSD PF03909.17 EDO14922.1 - 4.4e-22 77.8 2.9 3e-10 39.9 0.3 2.7 2 0 0 2 2 2 2 BSD domain PH_TFIIH PF08567.11 EDO14922.1 - 7.6e-18 64.6 1.8 1.2e-17 64.0 0.4 2.1 2 0 0 2 2 2 1 TFIIH p62 subunit, N-terminal domain FTR_C PF02741.15 EDO14922.1 - 0.27 11.3 1.9 0.36 10.8 0.7 1.7 2 0 0 2 2 2 0 FTR, proximal lobe DEAD PF00270.29 EDO14923.1 - 2.4e-49 167.5 0.0 4.3e-49 166.6 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDO14923.1 - 2e-30 105.4 0.2 1.7e-29 102.4 0.1 2.6 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDO14923.1 - 3.3e-06 27.2 0.1 1.6e-05 24.9 0.0 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 EDO14923.1 - 0.0035 16.6 0.0 0.0035 16.6 0.0 2.1 2 0 0 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase AAA_19 PF13245.6 EDO14923.1 - 0.0055 17.1 0.0 0.14 12.5 0.0 2.5 2 0 0 2 2 2 1 AAA domain GLTP PF08718.11 EDO14923.1 - 0.0097 16.2 0.9 0.087 13.1 0.1 2.8 3 1 0 3 3 3 1 Glycolipid transfer protein (GLTP) SpoVIF PF14069.6 EDO14923.1 - 0.26 11.1 5.7 12 5.8 0.1 3.5 3 0 0 3 3 3 0 Stage VI sporulation protein F FAM176 PF14851.6 EDO14923.1 - 6.6 6.4 7.4 13 5.4 7.4 1.4 1 0 0 1 1 1 0 FAM176 family Brix PF04427.18 EDO14924.1 - 2.2e-51 174.8 3.8 3.4e-51 174.1 3.8 1.3 1 0 0 1 1 1 1 Brix domain DUF2514 PF10721.9 EDO14924.1 - 0.044 13.8 2.5 0.088 12.8 2.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2514) Ins_P5_2-kin PF06090.12 EDO14925.1 - 3e-14 53.2 1.0 7.5e-13 48.6 1.0 2.1 1 1 0 1 1 1 1 Inositol-pentakisphosphate 2-kinase DS PF01916.17 EDO14926.1 - 5.5e-133 442.6 0.0 6.3e-133 442.4 0.0 1.0 1 0 0 1 1 1 1 Deoxyhypusine synthase ECR1_N PF14382.6 EDO14927.1 - 2.5e-16 59.2 0.1 5e-16 58.2 0.1 1.5 1 0 0 1 1 1 1 Exosome complex exonuclease RRP4 N-terminal region KH_6 PF15985.5 EDO14927.1 - 3.3e-09 36.9 0.1 6.6e-09 36.0 0.1 1.5 1 0 0 1 1 1 1 KH domain EXOSC1 PF10447.9 EDO14927.1 - 0.0072 16.9 0.0 2.4 8.8 0.0 2.7 2 0 0 2 2 2 2 Exosome component EXOSC1/CSL4 Met_10 PF02475.16 EDO14928.1 - 3.4e-78 262.0 0.1 6.2e-78 261.1 0.1 1.4 1 0 0 1 1 1 1 Met-10+ like-protein TRM PF02005.16 EDO14928.1 - 0.00059 19.1 0.0 0.00096 18.4 0.0 1.3 1 0 0 1 1 1 1 N2,N2-dimethylguanosine tRNA methyltransferase MethyltransfD12 PF02086.15 EDO14928.1 - 0.00083 19.1 0.0 0.0016 18.1 0.0 1.5 1 0 0 1 1 1 1 D12 class N6 adenine-specific DNA methyltransferase PrmA PF06325.13 EDO14928.1 - 0.063 12.7 0.0 0.11 11.8 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Cyclin_N PF00134.23 EDO14929.1 - 2.9e-08 33.5 0.2 5.8e-08 32.5 0.2 1.5 1 0 0 1 1 1 1 Cyclin, N-terminal domain PAP1 PF08601.10 EDO14929.1 - 0.024 14.4 13.4 0.032 14.0 13.4 1.2 1 0 0 1 1 1 0 Transcription factor PAP1 PNISR PF15996.5 EDO14929.1 - 0.11 12.8 3.4 0.17 12.1 3.4 1.2 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR Cyclin PF08613.11 EDO14929.1 - 0.11 12.8 7.2 0.27 11.6 7.1 1.7 1 1 0 1 1 1 0 Cyclin Menin PF05053.13 EDO14929.1 - 0.37 9.1 3.3 0.46 8.8 3.3 1.1 1 0 0 1 1 1 0 Menin Flocculin PF00624.18 EDO14930.1 - 3.1e-12 46.5 52.3 3.7e-07 30.3 21.6 4.4 4 1 1 5 5 5 2 Flocculin repeat Flocculin PF00624.18 EDO14931.1 - 0 1044.8 1188.2 1.1e-12 48.0 22.1 163.7 152 104 1 153 153 153 38 Flocculin repeat PDR_assoc PF08370.11 EDO14931.1 - 5.3e-25 86.9 108.0 35 4.2 0.1 33.3 33 0 0 33 33 33 33 Plant PDR ABC transporter associated GATA PF00320.27 EDO14934.1 - 1.2e-16 60.0 2.1 2.2e-16 59.1 2.1 1.5 1 0 0 1 1 1 1 GATA zinc finger DUF1690 PF07956.11 EDO14935.1 - 3.3e-40 137.7 2.8 3.8e-40 137.5 2.8 1.0 1 0 0 1 1 1 1 Protein of Unknown function (DUF1690) Aquarius_N PF16399.5 EDO14935.1 - 0.031 12.3 1.8 0.035 12.2 1.8 1.0 1 0 0 1 1 1 0 Intron-binding protein aquarius N-terminus Pirin PF02678.16 EDO14936.1 - 1.2e-27 96.0 0.1 4.9e-26 90.8 0.1 2.2 2 0 0 2 2 2 1 Pirin Pirin_C PF05726.13 EDO14936.1 - 2.1e-15 57.0 0.0 9.2e-15 54.9 0.0 1.9 2 0 0 2 2 2 1 Pirin C-terminal cupin domain Cupin_2 PF07883.11 EDO14936.1 - 1.5e-05 24.6 0.6 0.00016 21.3 0.4 2.2 2 0 0 2 2 2 1 Cupin domain NIL PF09383.10 EDO14936.1 - 0.15 11.9 0.1 2.6 8.0 0.0 2.3 2 0 0 2 2 2 0 NIL domain Ran_BP1 PF00638.18 EDO14937.1 - 6.4e-37 126.5 1.7 8.3e-37 126.2 0.3 2.0 2 0 0 2 2 2 1 RanBP1 domain NUP50 PF08911.11 EDO14937.1 - 5.2e-14 52.7 4.7 5.2e-14 52.7 4.7 5.0 5 1 0 5 5 5 1 NUP50 (Nucleoporin 50 kDa) AAA PF00004.29 EDO14938.1 - 5e-37 127.3 0.0 1e-36 126.3 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EDO14938.1 - 2.4e-10 40.1 0.0 4.9e-10 39.1 0.0 1.5 1 0 0 1 1 1 1 AAA+ lid domain AAA_14 PF13173.6 EDO14938.1 - 3.3e-07 30.4 0.0 1.2e-06 28.6 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EDO14938.1 - 4.2e-06 27.2 0.1 5.3e-05 23.7 0.0 2.6 1 1 1 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 EDO14938.1 - 4.8e-06 26.4 0.0 1.5e-05 24.8 0.0 1.8 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 EDO14938.1 - 1.3e-05 25.2 0.5 0.00013 22.0 0.1 2.7 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) TniB PF05621.11 EDO14938.1 - 2.3e-05 23.9 0.0 0.13 11.6 0.0 2.3 1 1 1 2 2 2 2 Bacterial TniB protein AAA_22 PF13401.6 EDO14938.1 - 2.9e-05 24.4 0.4 0.0031 17.8 0.0 3.0 1 1 2 3 3 3 1 AAA domain AAA_2 PF07724.14 EDO14938.1 - 4e-05 23.8 0.0 0.00012 22.3 0.0 1.8 2 0 0 2 2 1 1 AAA domain (Cdc48 subfamily) AAA_18 PF13238.6 EDO14938.1 - 9.1e-05 23.0 0.0 0.00028 21.4 0.0 1.9 2 0 0 2 2 1 1 AAA domain Bac_DnaA PF00308.18 EDO14938.1 - 0.00014 21.8 0.0 0.00029 20.8 0.0 1.5 1 0 0 1 1 1 1 Bacterial dnaA protein Sigma54_activ_2 PF14532.6 EDO14938.1 - 0.00032 20.8 0.0 0.00066 19.8 0.0 1.4 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_33 PF13671.6 EDO14938.1 - 0.00039 20.6 0.0 0.00078 19.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 EDO14938.1 - 0.00047 19.9 0.0 0.0013 18.5 0.0 1.7 2 0 0 2 2 2 1 IstB-like ATP binding protein RNA_helicase PF00910.22 EDO14938.1 - 0.00064 20.1 0.1 0.002 18.5 0.0 1.9 2 0 0 2 2 2 1 RNA helicase Mg_chelatase PF01078.21 EDO14938.1 - 0.00069 19.1 0.2 0.0018 17.7 0.2 1.6 1 1 0 1 1 1 1 Magnesium chelatase, subunit ChlI Rad17 PF03215.15 EDO14938.1 - 0.00091 19.2 0.6 0.0031 17.4 0.1 2.1 2 1 0 2 2 2 1 Rad17 P-loop domain DUF815 PF05673.13 EDO14938.1 - 0.0018 17.5 0.0 0.0042 16.3 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF815) Hydin_ADK PF17213.3 EDO14938.1 - 0.0023 18.3 1.2 0.91 9.8 0.0 2.3 2 0 0 2 2 2 1 Hydin Adenylate kinase-like domain AAA_24 PF13479.6 EDO14938.1 - 0.0034 17.1 0.0 0.0069 16.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.6 EDO14938.1 - 0.0041 17.5 1.4 0.02 15.3 0.1 2.6 2 1 0 2 2 2 1 AAA domain NACHT PF05729.12 EDO14938.1 - 0.0061 16.5 0.1 0.015 15.2 0.1 1.7 1 0 0 1 1 1 1 NACHT domain ABC_tran PF00005.27 EDO14938.1 - 0.0061 17.1 0.1 0.019 15.5 0.1 2.1 1 1 0 1 1 1 1 ABC transporter AAA_25 PF13481.6 EDO14938.1 - 0.0063 16.1 0.0 0.054 13.1 0.0 2.1 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.12 EDO14938.1 - 0.0068 15.7 0.0 0.014 14.7 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin AAA_28 PF13521.6 EDO14938.1 - 0.0084 16.4 0.0 0.015 15.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_7 PF12775.7 EDO14938.1 - 0.0088 15.6 0.0 0.028 13.9 0.0 1.9 1 1 0 1 1 1 1 P-loop containing dynein motor region TIP49 PF06068.13 EDO14938.1 - 0.009 15.3 0.1 0.022 14.0 0.1 1.6 1 1 1 2 2 2 1 TIP49 P-loop domain Sigma54_activat PF00158.26 EDO14938.1 - 0.014 15.1 0.0 0.047 13.4 0.0 1.8 2 0 0 2 2 2 0 Sigma-54 interaction domain ATPase_2 PF01637.18 EDO14938.1 - 0.025 14.5 0.3 0.13 12.1 0.0 2.2 1 1 1 2 2 2 0 ATPase domain predominantly from Archaea AAA_3 PF07726.11 EDO14938.1 - 0.027 14.3 0.0 0.069 13.0 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) TsaE PF02367.17 EDO14938.1 - 0.031 14.3 0.0 0.065 13.2 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Parvo_NS1 PF01057.17 EDO14938.1 - 0.036 13.2 0.0 0.087 11.9 0.0 1.6 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 Viral_helicase1 PF01443.18 EDO14938.1 - 0.049 13.4 0.0 0.15 11.8 0.0 1.7 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase KAP_NTPase PF07693.14 EDO14938.1 - 0.13 11.5 2.2 1.2 8.2 0.0 2.4 2 1 1 3 3 3 0 KAP family P-loop domain Evr1_Alr PF04777.13 EDO14939.1 - 2.8e-30 104.7 4.9 4.8e-30 104.0 4.9 1.4 1 0 0 1 1 1 1 Erv1 / Alr family LolA_2 PF16584.5 EDO14939.1 - 0.068 13.1 0.0 0.091 12.6 0.0 1.1 1 0 0 1 1 1 0 Outer membrane lipoprotein carrier protein LolA Ribosomal_L10 PF00466.20 EDO14940.1 - 6.6e-25 87.2 0.3 1.1e-24 86.4 0.3 1.3 1 0 0 1 1 1 1 Ribosomal protein L10 RL10P_insert PF17777.1 EDO14940.1 - 5.2e-21 74.4 0.0 8.6e-21 73.7 0.0 1.4 1 0 0 1 1 1 1 Insertion domain in 60S ribosomal protein L10P Ribosomal_60s PF00428.19 EDO14940.1 - 4.1e-20 72.2 6.9 5.9e-20 71.7 3.6 2.2 2 0 0 2 2 2 1 60s Acidic ribosomal protein RNase_H2_suC PF08615.11 EDO14940.1 - 0.18 11.9 0.0 0.22 11.7 0.0 1.6 1 1 0 1 1 1 0 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) DUF2624 PF11116.8 EDO14942.1 - 0.004 18.0 0.2 0.014 16.3 0.1 1.9 1 1 0 1 1 1 1 Protein of unknown function (DUF2624) DUF484 PF04340.12 EDO14942.1 - 0.075 12.7 0.0 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF484 Abhydrolase_1 PF00561.20 EDO14943.1 - 4.2e-16 59.4 0.0 1.3e-15 57.8 0.0 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EDO14943.1 - 1.9e-11 45.0 0.0 1.5e-10 42.1 0.0 1.9 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EDO14943.1 - 1e-06 28.2 0.0 1.5e-06 27.7 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 PGAP1 PF07819.13 EDO14943.1 - 4.4e-05 23.3 0.6 0.00078 19.2 0.0 2.4 2 1 1 3 3 3 1 PGAP1-like protein Thioesterase PF00975.20 EDO14943.1 - 0.00023 21.4 0.0 0.00033 20.8 0.0 1.4 1 1 0 1 1 1 1 Thioesterase domain Palm_thioest PF02089.15 EDO14943.1 - 0.035 13.9 0.0 0.054 13.3 0.0 1.4 1 1 0 1 1 1 0 Palmitoyl protein thioesterase DUF3530 PF12048.8 EDO14943.1 - 0.051 13.0 0.0 0.073 12.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3530) Lipase_3 PF01764.25 EDO14943.1 - 0.066 13.1 0.0 0.087 12.7 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) DUF1450 PF07293.11 EDO14943.1 - 0.1 12.4 0.2 0.31 10.9 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1450) Glucan_synthase PF02364.15 EDO14944.1 - 6.4e-169 563.8 0.0 1e-168 563.2 0.0 1.3 1 0 0 1 1 1 1 1,3-beta-glucan synthase component FKS1_dom1 PF14288.6 EDO14944.1 - 1.2e-45 155.0 0.1 1.2e-45 155.0 0.1 2.0 2 0 0 2 2 2 1 1,3-beta-glucan synthase subunit FKS1, domain-1 Homeodomain PF00046.29 EDO14945.1 - 3.2e-14 52.5 0.9 5.3e-14 51.8 0.9 1.4 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EDO14945.1 - 1.1e-06 28.5 0.2 2.2e-06 27.4 0.1 1.6 2 0 0 2 2 2 1 Homeobox KN domain Homez PF11569.8 EDO14945.1 - 0.0021 17.5 0.0 0.0041 16.6 0.0 1.4 1 0 0 1 1 1 1 Homeodomain leucine-zipper encoding, Homez DUF5100 PF17029.5 EDO14945.1 - 0.039 13.8 0.1 0.048 13.5 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5100) Flocculin PF00624.18 EDO14946.1 - 7.5e-27 93.3 159.7 4.4e-08 33.2 17.6 185.7 188 0 0 188 188 188 14 Flocculin repeat Peptidase_C13 PF01650.18 EDO14948.1 - 5e-47 160.6 0.7 7.9e-47 159.9 0.7 1.3 1 0 0 1 1 1 1 Peptidase C13 family ResIII PF04851.15 EDO14949.1 - 2.6e-26 92.6 0.2 2.6e-26 92.6 0.2 2.5 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EDO14949.1 - 7.1e-16 58.5 2.4 6.5e-15 55.3 0.2 2.5 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDO14949.1 - 5.6e-15 55.7 2.2 1.8e-12 47.6 0.0 3.6 3 1 0 3 3 3 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 EDO14949.1 - 7.5e-05 23.0 0.1 0.00054 20.2 0.0 2.4 2 0 0 2 2 2 1 AAA domain DUF2075 PF09848.9 EDO14949.1 - 0.00018 20.9 0.1 0.00018 20.9 0.1 2.1 3 0 0 3 3 3 1 Uncharacterized conserved protein (DUF2075) LMBR1 PF04791.16 EDO14949.1 - 0.11 11.4 4.7 0.15 11.0 0.2 2.6 3 0 0 3 3 3 0 LMBR1-like membrane protein DUF4404 PF14357.6 EDO14949.1 - 0.15 12.7 3.0 1.1 10.0 3.0 2.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4404) Cutinase PF01083.22 EDO14949.1 - 0.17 11.8 0.0 0.38 10.7 0.0 1.5 1 0 0 1 1 1 0 Cutinase Brix PF04427.18 EDO14950.1 - 2.9e-27 96.0 2.2 2.9e-27 96.0 2.2 1.6 1 1 1 2 2 2 1 Brix domain Pex19 PF04614.12 EDO14950.1 - 0.0062 16.4 5.9 0.01 15.6 5.9 1.4 1 0 0 1 1 1 1 Pex19 protein family CCDC71L PF15374.6 EDO14950.1 - 0.76 9.0 5.0 1 8.6 5.0 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 71L Xpo1 PF08389.12 EDO14951.1 - 0.00064 19.8 10.5 0.087 12.9 0.6 4.0 3 0 0 3 3 3 2 Exportin 1-like protein IBN_N PF03810.19 EDO14951.1 - 0.065 13.2 3.6 0.47 10.4 0.1 3.4 3 0 0 3 3 3 0 Importin-beta N-terminal domain MMR_HSR1 PF01926.23 EDO14952.1 - 4.1e-17 62.3 0.0 8e-17 61.4 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EDO14952.1 - 2.7e-09 37.2 0.0 4.3e-07 30.0 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase FeoB_N PF02421.18 EDO14952.1 - 1.9e-05 24.2 0.1 4.2e-05 23.1 0.1 1.5 1 1 0 1 1 1 1 Ferrous iron transport protein B GTP_EFTU PF00009.27 EDO14952.1 - 6.8e-05 22.5 0.0 0.0012 18.4 0.0 2.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 EDO14952.1 - 0.0001 22.4 3.4 0.24 11.5 1.0 2.9 2 1 1 3 3 3 2 Dynamin family SRPRB PF09439.10 EDO14952.1 - 0.005 16.3 0.0 0.01 15.3 0.0 1.5 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 EDO14952.1 - 0.0066 16.1 0.0 0.012 15.2 0.0 1.4 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EDO14952.1 - 0.017 15.3 0.0 0.05 13.8 0.0 2.0 1 1 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase DUF815 PF05673.13 EDO14952.1 - 0.04 13.1 0.0 0.096 11.8 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF815) ABC_tran PF00005.27 EDO14952.1 - 0.084 13.4 0.2 0.28 11.7 0.1 1.9 1 1 1 2 2 2 0 ABC transporter MatE PF01554.18 EDO14953.1 - 7e-65 217.6 36.2 2.6e-41 141.0 9.0 2.8 3 0 0 3 3 3 2 MatE Sugar_tr PF00083.24 EDO14954.1 - 5.4e-166 552.9 32.1 6.7e-166 552.6 32.1 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDO14954.1 - 8.9e-29 100.5 40.0 5.2e-27 94.7 20.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Svf1 PF08622.10 EDO14955.1 - 1.1e-67 227.2 0.1 2e-67 226.3 0.1 1.5 1 0 0 1 1 1 1 Svf1-like N-terminal lipocalin domain Svf1_C PF17187.4 EDO14955.1 - 9.3e-66 220.7 1.9 9.3e-66 220.7 1.9 1.6 2 0 0 2 2 2 1 Svf1-like C-terminal lipocalin-like domain Nop14 PF04147.12 EDO14955.1 - 0.00014 20.3 12.0 0.00019 19.8 12.0 1.1 1 0 0 1 1 1 1 Nop14-like family SAPS PF04499.15 EDO14955.1 - 0.0038 16.1 2.3 0.0054 15.6 2.3 1.2 1 0 0 1 1 1 1 SIT4 phosphatase-associated protein CDC45 PF02724.14 EDO14955.1 - 0.013 13.8 7.3 0.016 13.5 7.3 1.2 1 0 0 1 1 1 0 CDC45-like protein Afi1 PF07792.12 EDO14955.1 - 0.075 13.5 5.8 0.19 12.2 5.8 1.7 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Cwf_Cwc_15 PF04889.12 EDO14955.1 - 0.075 12.8 17.8 0.15 11.8 17.8 1.4 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein FAM60A PF15396.6 EDO14955.1 - 0.076 13.0 0.3 0.14 12.2 0.3 1.3 1 0 0 1 1 1 0 Protein Family FAM60A DUF913 PF06025.12 EDO14955.1 - 0.2 10.6 2.5 0.15 11.0 1.1 1.5 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) NPR3 PF03666.13 EDO14955.1 - 0.23 10.2 3.0 0.33 9.7 3.0 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Zip PF02535.22 EDO14955.1 - 0.3 10.3 1.0 0.39 9.9 1.0 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter RNA_pol_3_Rpc31 PF11705.8 EDO14955.1 - 0.54 10.5 22.9 1.1 9.5 22.9 1.4 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 Drc1-Sld2 PF11719.8 EDO14955.1 - 0.83 9.1 8.5 1.5 8.3 8.5 1.3 1 0 0 1 1 1 0 DNA replication and checkpoint protein NOA36 PF06524.12 EDO14955.1 - 0.97 8.7 21.3 1.6 8.0 21.3 1.2 1 0 0 1 1 1 0 NOA36 protein Vfa1 PF08432.10 EDO14955.1 - 2.2 8.6 7.9 4.4 7.6 7.9 1.4 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 TRAP_alpha PF03896.16 EDO14955.1 - 5.6 6.1 11.7 12 5.0 11.7 1.5 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Pal1 PF08316.11 EDO14956.1 - 2.9e-49 167.4 2.6 2.9e-49 167.4 2.6 2.8 2 1 1 3 3 3 1 Pal1 cell morphology protein TMEM51 PF15345.6 EDO14956.1 - 6.9 6.4 11.4 17 5.1 11.2 1.7 1 1 0 1 1 1 0 Transmembrane protein 51 Sec23_trunk PF04811.15 EDO14957.1 - 9.9e-58 195.6 0.4 1.5e-57 195.0 0.4 1.3 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.15 EDO14957.1 - 2.9e-15 56.0 0.1 2.7e-14 52.8 0.0 2.5 2 0 0 2 2 2 1 Sec23/Sec24 helical domain Sec23_BS PF08033.12 EDO14957.1 - 2e-11 44.5 0.4 5e-11 43.2 0.4 1.7 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.15 EDO14957.1 - 3.1e-10 39.9 3.6 8.7e-10 38.5 3.6 1.8 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 EDO14957.1 - 1.7e-06 27.9 0.1 4.2e-06 26.6 0.1 1.7 1 0 0 1 1 1 1 Gelsolin repeat VWA_2 PF13519.6 EDO14957.1 - 0.0004 21.0 0.1 0.19 12.4 0.0 2.8 3 0 0 3 3 3 2 von Willebrand factor type A domain MIP PF00230.20 EDO14958.1 - 2.8e-64 216.9 8.8 3.7e-64 216.5 8.8 1.1 1 0 0 1 1 1 1 Major intrinsic protein V-SNARE_C PF12352.8 EDO14959.1 - 6.1e-15 55.3 5.3 6.1e-15 55.3 5.3 2.2 2 1 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus WXG100 PF06013.12 EDO14959.1 - 0.0039 17.4 3.5 14 6.0 0.1 3.5 3 0 0 3 3 3 2 Proteins of 100 residues with WXG RseA_N PF03872.13 EDO14959.1 - 0.022 15.2 1.0 0.047 14.2 1.0 1.7 1 1 0 1 1 1 0 Anti sigma-E protein RseA, N-terminal domain Sec20 PF03908.13 EDO14959.1 - 0.03 14.3 9.4 0.078 12.9 0.5 3.4 1 1 3 4 4 4 0 Sec20 DUF4248 PF14053.6 EDO14959.1 - 0.17 11.9 0.2 0.45 10.6 0.2 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4248) BORCS7 PF16088.5 EDO14959.1 - 0.28 11.5 9.2 0.054 13.8 2.8 2.3 2 0 0 2 2 2 0 BLOC-1-related complex sub-unit 7 DUF2259 PF10016.9 EDO14959.1 - 0.34 10.8 3.4 0.26 11.2 0.5 1.9 2 0 0 2 2 2 0 Predicted secreted protein (DUF2259) Endotoxin_N PF03945.14 EDO14959.1 - 0.44 10.2 6.4 0.36 10.5 5.1 1.6 1 1 0 1 1 1 0 delta endotoxin, N-terminal domain DUF2721 PF11026.8 EDO14959.1 - 7.2 6.5 6.8 1.9 8.4 0.1 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF2721) Syntaxin-6_N PF09177.11 EDO14959.1 - 8.6 7.0 11.7 1.4 9.5 4.4 2.4 1 1 1 2 2 2 0 Syntaxin 6, N-terminal DUF948 PF06103.11 EDO14959.1 - 9 6.6 6.9 4.4 7.6 2.2 2.5 1 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Fer2_3 PF13085.6 EDO14960.1 - 2.6e-32 111.1 0.1 4.4e-32 110.3 0.1 1.4 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Fer4_17 PF13534.6 EDO14960.1 - 1.9e-09 38.0 7.5 1.9e-09 38.0 7.5 2.0 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_8 PF13183.6 EDO14960.1 - 5.5e-08 33.1 8.0 5.5e-08 33.1 8.0 2.3 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_10 PF13237.6 EDO14960.1 - 1.5e-07 31.5 3.5 1.5e-07 31.5 3.5 2.0 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer2 PF00111.27 EDO14960.1 - 0.00041 20.2 3.8 0.006 16.5 1.3 2.4 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain Fer4_7 PF12838.7 EDO14960.1 - 0.001 19.6 5.2 0.001 19.6 5.2 2.3 2 2 0 2 2 2 1 4Fe-4S dicluster domain Fer4_9 PF13187.6 EDO14960.1 - 0.0097 16.1 7.5 0.0097 16.1 7.5 2.4 2 1 0 2 2 2 1 4Fe-4S dicluster domain Fer4_18 PF13746.6 EDO14960.1 - 0.013 15.6 0.6 0.74 10.0 0.1 2.4 2 0 0 2 2 2 0 4Fe-4S dicluster domain SF3a60_bindingd PF12108.8 EDO14960.1 - 0.15 12.0 0.2 0.25 11.3 0.2 1.4 1 0 0 1 1 1 0 Splicing factor SF3a60 binding domain SHR-BD PF06650.12 EDO14961.1 - 3.9e-92 308.5 1.3 1.9e-91 306.2 0.3 2.5 2 0 0 2 2 2 1 SHR-binding domain of vacuolar-sorting associated protein 13 VPS13_mid_rpt PF16910.5 EDO14961.1 - 1.3e-85 286.6 9.3 3e-80 269.0 0.0 5.6 4 1 0 5 5 5 4 Repeating coiled region of VPS13 VPS13_C PF16909.5 EDO14961.1 - 8e-73 244.0 5.5 5.9e-67 224.9 0.6 3.2 2 0 0 2 2 2 2 Vacuolar-sorting-associated 13 protein C-terminal VPS13 PF16908.5 EDO14961.1 - 5.7e-69 232.5 6.2 1.5e-67 227.9 3.0 3.6 3 0 0 3 3 3 1 Vacuolar sorting-associated protein 13, N-terminal Chorein_N PF12624.7 EDO14961.1 - 1.4e-37 128.3 0.2 5.5e-37 126.4 0.2 2.2 1 0 0 1 1 1 1 N-terminal region of Chorein or VPS13 ENTH PF01417.20 EDO14962.1 - 3.5e-36 124.0 1.1 5.3e-36 123.4 1.1 1.3 1 0 0 1 1 1 1 ENTH domain ANTH PF07651.16 EDO14962.1 - 0.0057 15.7 0.2 0.0091 15.0 0.2 1.4 1 0 0 1 1 1 1 ANTH domain DUF3837 PF12939.7 EDO14962.1 - 0.63 10.5 3.7 7.1 7.1 0.1 2.7 2 1 0 3 3 3 0 Domain of unknown function (DUF3837) Prp19 PF08606.11 EDO14963.1 - 4.6e-27 93.8 1.4 1.1e-26 92.6 1.4 1.7 1 0 0 1 1 1 1 Prp19/Pso4-like U-box PF04564.15 EDO14963.1 - 0.00024 21.2 0.2 0.0013 18.8 0.0 2.2 2 0 0 2 2 2 1 U-box domain DUF4200 PF13863.6 EDO14963.1 - 0.0024 18.3 6.8 0.0042 17.5 6.8 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4200) zf-Nse PF11789.8 EDO14963.1 - 0.092 12.6 0.0 0.33 10.8 0.0 1.9 1 1 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit HALZ PF02183.18 EDO14963.1 - 3.9 7.8 6.9 7.6 6.8 0.8 3.2 3 0 0 3 3 3 0 Homeobox associated leucine zipper zf-C2H2 PF00096.26 EDO14964.1 - 5.4e-05 23.4 3.1 5.4e-05 23.4 3.1 4.1 4 0 0 4 4 4 1 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 EDO14964.1 - 0.0027 17.9 0.4 0.0091 16.3 0.4 2.0 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 EDO14964.1 - 0.0078 17.0 2.0 0.0078 17.0 2.0 3.7 4 0 0 4 4 4 1 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EDO14964.1 - 0.0093 16.4 3.8 0.0093 16.4 3.8 2.9 3 0 0 3 3 3 1 Zinc-finger double domain zf-met PF12874.7 EDO14964.1 - 0.012 16.0 0.6 0.012 16.0 0.6 2.1 2 0 0 2 2 2 0 Zinc-finger of C2H2 type DUF3246 PF11596.8 EDO14964.1 - 0.17 11.3 9.7 0.38 10.1 9.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3246) zf-C2H2_8 PF15909.5 EDO14964.1 - 0.28 11.5 5.3 0.95 9.8 5.3 2.0 1 0 0 1 1 1 0 C2H2-type zinc ribbon Peptidase_C28 PF05408.11 EDO14965.1 - 0.016 14.9 0.0 0.041 13.6 0.0 1.6 1 0 0 1 1 1 0 Foot-and-mouth virus L-proteinase Big_8 PF17961.1 EDO14966.1 - 0.94 9.7 3.9 4.5 7.5 0.7 2.6 1 1 2 3 3 3 0 Bacterial Ig domain KH_1 PF00013.29 EDO14967.1 - 1.1e-11 44.4 0.1 0.0047 16.7 0.0 4.9 5 0 0 5 5 5 3 KH domain Endopep_inhib PF16800.5 EDO14967.1 - 0.001 19.1 3.0 0.0044 17.0 3.0 2.1 1 0 0 1 1 1 1 IseA DL-endopeptidase inhibitor RasGEF PF00617.19 EDO14968.1 - 1.8e-55 187.9 3.7 3.8e-55 186.8 1.1 2.9 2 0 0 2 2 2 1 RasGEF domain RasGEF_N PF00618.20 EDO14968.1 - 1.1e-20 73.8 0.4 1.1e-20 73.8 0.4 5.8 5 1 0 5 5 5 1 RasGEF N-terminal motif SH3_1 PF00018.28 EDO14968.1 - 5.1e-08 32.4 0.5 1.7e-07 30.7 0.4 1.9 2 0 0 2 2 2 1 SH3 domain SH3_2 PF07653.17 EDO14968.1 - 7.1e-08 32.0 0.1 1.9e-07 30.7 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 EDO14968.1 - 1.3e-07 31.4 0.0 2.9e-07 30.2 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain UQ_con PF00179.26 EDO14969.1 - 2.7e-35 121.1 0.0 3.7e-35 120.6 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UEV PF05743.13 EDO14969.1 - 0.028 14.3 0.0 0.046 13.6 0.0 1.4 1 0 0 1 1 1 0 UEV domain RWD PF05773.22 EDO14969.1 - 0.057 13.7 0.2 0.097 13.0 0.2 1.6 1 1 0 1 1 1 0 RWD domain PI3_PI4_kinase PF00454.27 EDO14970.1 - 8.6e-45 153.5 0.0 1.7e-42 146.0 0.0 2.5 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 EDO14970.1 - 3e-28 98.5 0.0 8.5e-28 97.0 0.0 1.8 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) RVT_2 PF07727.14 EDO14972.1 - 2.9e-38 131.9 1.4 6.4e-38 130.8 1.4 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 EDO14972.1 - 3.6e-12 46.5 0.0 7.5e-12 45.5 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain gag_pre-integrs PF13976.6 EDO14972.1 - 0.0012 18.6 0.1 0.0034 17.2 0.1 1.8 1 0 0 1 1 1 1 GAG-pre-integrase domain RVT_1 PF00078.27 EDO14972.1 - 0.024 14.2 0.8 0.27 10.7 0.0 2.7 3 0 0 3 3 3 0 Reverse transcriptase (RNA-dependent DNA polymerase) FA_hydroxylase PF04116.13 EDO14973.1 - 2.7e-24 86.0 23.3 2.7e-24 86.0 23.3 2.0 2 1 0 2 2 2 1 Fatty acid hydroxylase superfamily NTP_transferase PF00483.23 EDO14974.1 - 1.1e-53 182.4 0.0 1.4e-53 182.0 0.0 1.1 1 0 0 1 1 1 1 Nucleotidyl transferase Hexapep PF00132.24 EDO14974.1 - 3.7e-13 48.6 9.1 2.5e-08 33.3 1.3 4.0 1 1 3 4 4 4 3 Bacterial transferase hexapeptide (six repeats) NTP_transf_3 PF12804.7 EDO14974.1 - 5.9e-10 39.7 0.0 7.9e-10 39.3 0.0 1.2 1 0 0 1 1 1 1 MobA-like NTP transferase domain Fucokinase PF07959.12 EDO14974.1 - 0.0011 18.0 0.1 0.012 14.6 0.1 2.1 2 0 0 2 2 2 1 L-fucokinase Hexapep_2 PF14602.6 EDO14974.1 - 0.035 13.9 2.9 0.35 10.7 0.4 3.4 4 1 0 4 4 4 0 Hexapeptide repeat of succinyl-transferase DUF4954 PF16314.5 EDO14974.1 - 0.16 10.1 0.5 0.24 9.5 0.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4954) CTP_transf_3 PF02348.19 EDO14974.1 - 0.16 11.8 0.0 0.26 11.2 0.0 1.3 1 0 0 1 1 1 0 Cytidylyltransferase DUF4149 PF13664.6 EDO14975.1 - 9.1e-05 22.7 0.4 0.00028 21.2 0.1 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4149) ETRAMP PF09716.10 EDO14975.1 - 0.051 13.6 0.3 0.075 13.1 0.3 1.4 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) MAS20 PF02064.15 EDO14976.1 - 1.3e-33 115.9 0.9 1.6e-33 115.5 0.9 1.1 1 0 0 1 1 1 1 MAS20 protein import receptor PsbN PF02468.15 EDO14976.1 - 0.084 12.7 0.7 0.17 11.7 0.7 1.5 1 0 0 1 1 1 0 Photosystem II reaction centre N protein (psbN) MFS_Mycoplasma PF07672.13 EDO14976.1 - 0.12 11.6 0.1 0.15 11.3 0.1 1.2 1 0 0 1 1 1 0 Mycoplasma MFS transporter DUF3818 PF12825.7 EDO14977.1 - 2.6e-125 417.9 11.5 2.6e-125 417.9 11.5 2.2 3 0 0 3 3 3 1 Domain of unknown function in PX-proteins (DUF3818) PXB PF12828.7 EDO14977.1 - 7.7e-41 139.1 1.1 7.7e-41 139.1 1.1 2.0 2 0 0 2 2 2 1 PX-associated PX PF00787.24 EDO14977.1 - 8.3e-12 45.1 1.0 5.5e-11 42.4 0.2 3.0 2 1 0 2 2 2 1 PX domain Cas6_N PF17952.1 EDO14977.1 - 0.062 13.6 1.8 7.1 6.9 0.2 3.3 2 0 0 2 2 2 0 Cas6 N-terminal domain PBP1_TM PF14812.6 EDO14977.1 - 0.51 10.7 6.6 1.4 9.4 2.5 3.0 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF1689 PF07954.11 EDO14978.1 - 2.9e-57 193.2 0.2 4.3e-57 192.6 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1689) CCDC24 PF15669.5 EDO14978.1 - 0.18 11.7 2.6 0.24 11.3 2.6 1.3 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 24 family DHO_dh PF01180.21 EDO14979.1 - 9.8e-98 327.0 0.1 1.2e-97 326.7 0.1 1.1 1 0 0 1 1 1 1 Dihydroorotate dehydrogenase FMN_dh PF01070.18 EDO14979.1 - 0.0029 16.7 0.0 0.13 11.2 0.1 2.5 2 1 0 2 2 2 1 FMN-dependent dehydrogenase Amdase PF17645.1 EDO14979.1 - 0.13 11.9 0.0 5.9 6.4 0.0 2.3 2 0 0 2 2 2 0 Arylmalonate decarboxylase Syntaxin-5_N PF11416.8 EDO14979.1 - 0.15 11.3 0.1 0.33 10.3 0.1 1.5 1 0 0 1 1 1 0 Syntaxin-5 N-terminal, Sly1p-binding domain Dimer_Tnp_hAT PF05699.14 EDO14980.1 - 3.3e-05 23.6 0.1 0.00011 22.0 0.1 1.9 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region BING4CT PF08149.11 EDO14981.1 - 1.2e-37 127.6 0.3 1.1e-35 121.3 0.0 3.3 4 0 0 4 4 4 1 BING4CT (NUC141) domain ANAPC4_WD40 PF12894.7 EDO14981.1 - 3.9e-07 30.3 0.0 6.5 7.1 0.0 4.9 2 1 2 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EDO14981.1 - 6.6e-07 29.9 0.0 0.0015 19.3 0.0 4.6 5 0 0 5 5 5 1 WD domain, G-beta repeat Nup160 PF11715.8 EDO14981.1 - 0.027 13.1 0.0 0.051 12.2 0.0 1.4 1 0 0 1 1 1 0 Nucleoporin Nup120/160 RPN2_C PF18004.1 EDO14982.1 - 8.9e-51 172.0 11.2 1.4e-50 171.3 11.2 1.3 1 0 0 1 1 1 1 26S proteasome regulatory subunit RPN2 C-terminal domain PC_rep PF01851.22 EDO14982.1 - 1.7e-38 129.1 26.7 8.1e-06 26.0 0.0 8.9 8 0 0 8 8 8 8 Proteasome/cyclosome repeat HEAT_2 PF13646.6 EDO14982.1 - 2.9e-18 66.0 2.9 2.5e-15 56.6 0.1 4.3 4 0 0 4 4 4 1 HEAT repeats HEAT PF02985.22 EDO14982.1 - 4.9e-08 32.6 3.7 0.6 10.5 0.0 4.9 5 0 0 5 5 5 3 HEAT repeat HEAT_EZ PF13513.6 EDO14982.1 - 6.1e-06 26.6 5.0 0.019 15.5 0.1 4.8 4 1 1 5 5 5 3 HEAT-like repeat DUF3824 PF12868.7 EDO14982.1 - 0.013 16.2 2.3 0.028 15.1 2.3 1.5 1 0 0 1 1 1 0 Domain of unknwon function (DUF3824) Cnd1 PF12717.7 EDO14982.1 - 0.042 13.9 4.2 7 6.7 0.0 3.9 3 1 0 3 3 3 0 non-SMC mitotic condensation complex subunit 1 RICTOR_V PF14668.6 EDO14982.1 - 0.047 13.9 0.0 0.29 11.4 0.0 2.5 1 1 0 1 1 1 0 Rapamycin-insensitive companion of mTOR, domain 5 DUF4775 PF16001.5 EDO14982.1 - 0.062 12.7 15.2 0.092 12.1 15.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4775) Striatin PF08232.12 EDO14982.1 - 0.15 12.6 10.8 0.3 11.7 10.8 1.4 1 0 0 1 1 1 0 Striatin family Vfa1 PF08432.10 EDO14982.1 - 9.2 6.6 15.4 17 5.7 15.4 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 2-Hacid_dh_C PF02826.19 EDO14983.1 - 1.1e-52 177.9 0.1 2.6e-52 176.8 0.0 1.6 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EDO14983.1 - 6.5e-36 123.0 0.1 8.6e-36 122.6 0.1 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 EDO14983.1 - 7.3e-06 26.2 0.3 2e-05 24.8 0.3 1.7 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase AdoHcyase_NAD PF00670.21 EDO14983.1 - 5.6e-05 23.3 0.1 0.00014 22.0 0.1 1.6 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain ACT PF01842.25 EDO14983.1 - 0.00016 21.3 0.0 0.00065 19.4 0.0 2.1 2 0 0 2 2 2 1 ACT domain IlvN PF07991.12 EDO14983.1 - 0.0046 16.6 0.1 0.012 15.2 0.0 1.8 2 0 0 2 2 2 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain Rossmann-like PF10727.9 EDO14983.1 - 0.03 14.2 0.1 0.094 12.6 0.1 1.9 1 0 0 1 1 1 0 Rossmann-like domain XdhC_C PF13478.6 EDO14983.1 - 0.078 13.5 0.0 0.25 11.9 0.0 1.9 2 0 0 2 2 2 0 XdhC Rossmann domain 3HCDH_N PF02737.18 EDO14983.1 - 0.094 12.6 0.3 0.43 10.4 0.2 2.2 1 1 1 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain APH PF01636.23 EDO14984.1 - 2.1e-08 34.4 0.0 2.5e-07 30.9 0.0 2.1 1 1 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 EDO14984.1 - 0.0065 15.9 0.0 2.6 7.4 0.0 2.4 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family PCI PF01399.27 EDO14985.1 - 0.00066 20.2 1.9 0.00093 19.7 0.4 2.1 2 0 0 2 2 2 1 PCI domain PPR_2 PF13041.6 EDO14986.1 - 1.4e-17 63.6 0.5 4.2e-12 46.1 0.0 3.5 3 0 0 3 3 3 2 PPR repeat family DUF668 PF05003.12 EDO14986.1 - 0.11 13.0 0.6 0.29 11.6 0.6 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF668) PPR_3 PF13812.6 EDO14986.1 - 2.1 8.5 0.0 2.1 8.5 0.0 3.9 5 0 0 5 5 5 0 Pentatricopeptide repeat domain MAM33 PF02330.16 EDO14987.1 - 7.2e-58 196.0 13.8 8.4e-58 195.8 13.8 1.0 1 0 0 1 1 1 1 Mitochondrial glycoprotein HMG_box PF00505.19 EDO14988.1 - 1.2e-24 86.5 0.3 1.9e-24 85.8 0.3 1.3 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EDO14988.1 - 1.1e-16 61.2 0.3 1.6e-16 60.6 0.3 1.2 1 0 0 1 1 1 1 HMG-box domain CHDNT PF08073.12 EDO14988.1 - 0.0051 16.7 0.0 0.0079 16.1 0.0 1.2 1 0 0 1 1 1 1 CHDNT (NUC034) domain Ccdc124 PF06244.12 EDO14988.1 - 0.007 16.9 0.2 0.02 15.4 0.0 1.7 1 1 1 2 2 2 1 Coiled-coil domain-containing protein 124 /Oxs1 YABBY PF04690.13 EDO14988.1 - 0.056 14.0 0.7 0.063 13.8 0.5 1.3 1 1 0 1 1 1 0 YABBY protein zf-Tim10_DDP PF02953.15 EDO14989.1 - 1.4e-15 56.7 0.1 1.9e-15 56.2 0.1 1.2 1 0 0 1 1 1 1 Tim10/DDP family zinc finger TTL PF03133.15 EDO14990.1 - 7.8e-77 258.3 4.9 1.4e-76 257.5 4.9 1.3 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family SurE PF01975.17 EDO14990.1 - 3.2e-46 157.6 0.0 6.1e-46 156.7 0.0 1.5 1 0 0 1 1 1 1 Survival protein SurE ATPgrasp_YheCD PF14398.6 EDO14990.1 - 1.6e-05 24.3 0.1 0.0043 16.3 0.0 2.7 3 0 0 3 3 3 2 YheC/D like ATP-grasp RXT2_N PF08595.11 EDO14991.1 - 1.4e-37 129.1 2.2 1.4e-37 129.1 2.2 2.6 3 0 0 3 3 3 1 RXT2-like, N-terminal Prominin PF05478.11 EDO14991.1 - 0.059 11.3 2.2 0.073 11.0 2.2 1.2 1 0 0 1 1 1 0 Prominin Pkinase PF00069.25 EDO14992.1 - 2.1e-59 201.0 0.2 6.6e-59 199.4 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO14992.1 - 6.3e-29 101.0 0.0 1e-28 100.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EDO14992.1 - 0.0013 17.7 0.1 0.0021 17.1 0.1 1.3 1 0 0 1 1 1 1 Haspin like kinase domain Sec8_exocyst PF04048.14 EDO14993.1 - 3.4e-53 179.4 11.9 3.9e-52 175.9 5.4 3.0 2 0 0 2 2 2 2 Sec8 exocyst complex component specific domain Vps54_N PF10475.9 EDO14993.1 - 0.00013 21.4 5.0 0.00013 21.4 5.0 2.7 2 1 0 2 2 2 1 Vacuolar-sorting protein 54, of GARP complex Flo11 PF10182.9 EDO14993.1 - 6.4 6.9 10.1 0.088 12.9 0.5 2.7 3 0 0 3 3 3 0 Flo11 domain ERCC4 PF02732.15 EDO14994.1 - 2.8e-19 69.8 3.8 2.8e-19 69.8 3.8 3.0 3 1 1 4 4 4 1 ERCC4 domain RLL PF10036.9 EDO14994.1 - 0.0044 16.9 1.0 0.0044 16.9 1.0 2.8 2 1 0 2 2 2 1 RNA transcription, translation and transport factor protein Fes1 PF08609.10 EDO14995.1 - 6.8e-23 81.4 1.0 6.8e-23 81.4 1.0 2.7 3 2 0 3 3 3 1 Nucleotide exchange factor Fes1 IBN_N PF03810.19 EDO14995.1 - 8.4e-05 22.4 1.3 0.0032 17.4 0.4 3.1 2 1 0 2 2 2 1 Importin-beta N-terminal domain Tti2 PF10521.9 EDO14995.1 - 0.00078 19.1 0.7 0.38 10.2 0.1 2.4 1 1 0 2 2 2 2 Tti2 family DUF3361 PF11841.8 EDO14995.1 - 0.0011 18.9 3.8 0.024 14.6 0.4 2.8 1 1 2 3 3 3 2 Domain of unknown function (DUF3361) RIX1 PF08167.12 EDO14995.1 - 0.0017 18.2 0.4 0.0044 16.8 0.0 1.8 2 0 0 2 2 2 1 rRNA processing/ribosome biogenesis DUF4704 PF15787.5 EDO14995.1 - 0.0042 16.4 2.6 0.25 10.5 0.1 2.8 1 1 2 3 3 3 2 Domain of unknown function (DUF4704) HEAT PF02985.22 EDO14995.1 - 0.005 17.0 0.0 4 7.9 0.0 3.2 3 0 0 3 3 2 1 HEAT repeat V-ATPase_H_C PF11698.8 EDO14995.1 - 0.0091 16.1 3.3 0.024 14.7 0.4 2.6 1 1 2 3 3 3 2 V-ATPase subunit H Arm PF00514.23 EDO14995.1 - 0.054 13.6 0.2 7.4 6.8 0.0 3.3 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 EDO14995.1 - 0.082 13.3 0.0 0.41 11.1 0.0 2.1 1 1 2 3 3 3 0 HEAT repeats HEAT_EZ PF13513.6 EDO14995.1 - 0.094 13.3 0.0 3.1 8.4 0.0 2.7 2 0 0 2 2 2 0 HEAT-like repeat SIP1 PF04938.12 EDO14996.1 - 6.5e-11 42.4 2.1 1.8e-09 37.6 2.1 2.6 1 1 0 1 1 1 1 Survival motor neuron (SMN) interacting protein 1 (SIP1) RhoGAP PF00620.27 EDO14996.1 - 0.07 13.0 0.2 0.74 9.6 0.1 2.2 2 0 0 2 2 2 0 RhoGAP domain Mito_carr PF00153.27 EDO14997.1 - 1.3e-58 194.9 2.3 8.3e-20 70.5 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein PRT_C PF08372.10 EDO14997.1 - 0.099 12.4 0.0 0.16 11.7 0.0 1.2 1 0 0 1 1 1 0 Plant phosphoribosyltransferase C-terminal CM_2 PF01817.21 EDO14998.1 - 7.7e-05 23.0 0.2 0.0032 17.8 0.1 2.8 2 2 0 2 2 2 1 Chorismate mutase type II DnaJ PF00226.31 EDO14999.1 - 2.4e-10 40.4 4.3 8.6e-10 38.6 4.3 1.9 1 1 0 1 1 1 1 DnaJ domain AIM3 PF17096.5 EDO15000.1 - 1e-28 100.1 13.3 1e-28 100.1 13.3 10.1 7 3 2 9 9 9 2 Altered inheritance of mitochondria protein 3 EF-hand_1 PF00036.32 EDO15001.1 - 8.6e-31 103.2 2.9 1.4e-08 33.7 0.0 4.3 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 EDO15001.1 - 1.1e-26 93.1 0.1 5.7e-14 52.3 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EDO15001.1 - 1.2e-26 90.3 2.3 5.5e-08 32.1 0.0 4.5 4 1 1 5 5 5 4 EF-hand domain EF-hand_5 PF13202.6 EDO15001.1 - 6.3e-21 72.9 3.2 4.9e-07 29.0 0.0 4.2 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.6 EDO15001.1 - 7.3e-17 61.0 4.4 7.3e-09 35.4 0.0 3.9 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_9 PF14658.6 EDO15001.1 - 2.5e-12 46.9 0.0 1.6e-08 34.7 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain SPARC_Ca_bdg PF10591.9 EDO15001.1 - 2.1e-06 28.0 0.1 0.0015 18.8 0.0 2.2 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_14 PF17959.1 EDO15001.1 - 6.7e-06 26.4 0.1 0.12 12.7 0.0 2.3 1 1 1 2 2 2 2 EF-hand domain UPF0154 PF03672.13 EDO15001.1 - 0.00013 21.9 0.0 0.064 13.3 0.0 2.9 3 0 0 3 3 3 1 Uncharacterised protein family (UPF0154) Dockerin_1 PF00404.18 EDO15001.1 - 0.00016 21.8 1.1 0.09 13.0 0.1 2.8 2 1 2 4 4 4 2 Dockerin type I domain Caleosin PF05042.13 EDO15001.1 - 0.0024 17.8 0.0 0.84 9.5 0.0 2.8 1 1 2 3 3 3 1 Caleosin related protein TerB PF05099.13 EDO15001.1 - 0.0028 17.6 0.1 0.05 13.6 0.0 2.2 2 1 0 2 2 2 1 Tellurite resistance protein TerB DUF853 PF05872.12 EDO15001.1 - 0.0052 15.4 0.2 0.041 12.5 0.2 2.0 1 1 0 1 1 1 1 Bacterial protein of unknown function (DUF853) EF-hand_11 PF08976.11 EDO15001.1 - 0.0082 17.0 0.0 3.3 8.6 0.0 2.1 1 1 1 2 2 2 1 EF-hand domain SurA_N_3 PF13624.6 EDO15001.1 - 0.011 15.5 0.8 0.39 10.5 0.4 2.0 1 1 1 2 2 2 0 SurA N-terminal domain EF-hand_4 PF12763.7 EDO15001.1 - 0.015 15.2 0.3 0.037 14.0 0.1 1.7 1 1 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand GPHH PF16905.5 EDO15001.1 - 0.077 12.8 0.0 0.87 9.4 0.0 2.3 2 0 0 2 2 2 0 Voltage-dependent L-type calcium channel, IQ-associated Glycos_trans_3N PF02885.17 EDO15001.1 - 0.11 12.4 3.1 4.3 7.3 0.1 3.4 1 1 1 2 2 2 0 Glycosyl transferase family, helical bundle domain RNA_pol_Rpb4 PF03874.16 EDO15001.1 - 0.15 12.4 1.5 1.7 9.0 1.5 2.5 1 1 0 1 1 1 0 RNA polymerase Rpb4 Hist_deacetyl PF00850.19 EDO15002.1 - 1.6e-85 287.3 0.0 4.9e-85 285.7 0.0 1.7 2 0 0 2 2 2 1 Histone deacetylase domain Serglycin PF04360.12 EDO15002.1 - 0.0023 17.9 0.7 0.0052 16.7 0.7 1.5 1 0 0 1 1 1 1 Serglycin AF-4 PF05110.13 EDO15002.1 - 0.013 13.7 0.7 0.017 13.3 0.7 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Med1 PF10744.9 EDO15003.1 - 2.6e-27 95.9 6.0 2.6e-27 95.9 6.0 2.9 1 1 1 2 2 2 1 Mediator of RNA polymerase II transcription subunit 1 NUDIX PF00293.28 EDO15004.1 - 7.2e-14 52.0 0.0 1.6e-13 50.8 0.0 1.5 2 0 0 2 2 2 1 NUDIX domain EnY2 PF10163.9 EDO15005.1 - 1.7e-06 28.3 0.1 1.8e-06 28.2 0.1 1.1 1 0 0 1 1 1 1 Transcription factor e(y)2 Macro PF01661.21 EDO15005.1 - 0.098 12.7 0.0 0.11 12.6 0.0 1.0 1 0 0 1 1 1 0 Macro domain HC2 PF07382.11 EDO15006.1 - 0.00065 19.8 0.0 0.0014 18.8 0.0 1.6 1 0 0 1 1 1 1 Histone H1-like nucleoprotein HC2 RRM_1 PF00076.22 EDO15007.1 - 2.7e-18 65.5 0.0 1.3e-15 57.0 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) YjeF_N PF03853.15 EDO15009.1 - 9.3e-38 129.8 0.0 1.1e-37 129.5 0.0 1.1 1 0 0 1 1 1 1 YjeF-related protein N-terminus SMK-1 PF04802.15 EDO15010.1 - 9.1e-60 201.8 8.3 9.1e-60 201.8 8.3 2.8 3 0 0 3 3 3 1 Component of IIS longevity pathway SMK-1 ArfGap PF01412.18 EDO15011.1 - 1.5e-32 112.1 0.0 3.3e-32 111.0 0.0 1.6 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf PH_18 PF18469.1 EDO15012.1 - 2.5e-51 173.4 2.2 2.5e-51 173.4 2.2 1.8 2 0 0 2 2 2 1 Pleckstrin homology domain Rtt106_N PF18215.1 EDO15012.1 - 1.5e-28 98.2 0.3 4.2e-28 96.8 0.3 1.8 1 0 0 1 1 1 1 Histone chaperone Rtt106 N-terminal domain Rtt106 PF08512.12 EDO15012.1 - 3.1e-27 94.8 2.0 5.9e-27 93.9 0.5 2.2 2 1 0 2 2 2 1 Histone chaperone Rttp106-like DUF1704 PF08014.11 EDO15012.1 - 0.007 15.4 1.1 0.011 14.8 1.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1704) Presenilin PF01080.17 EDO15012.1 - 6.2 5.5 11.1 8.7 5.0 11.1 1.2 1 0 0 1 1 1 0 Presenilin RIO1 PF01163.22 EDO15013.1 - 1.8e-41 141.8 0.7 2.6e-41 141.3 0.7 1.2 1 0 0 1 1 1 1 RIO1 family Rio2_N PF09202.11 EDO15013.1 - 1.9e-32 111.3 0.1 4.2e-32 110.2 0.1 1.6 1 0 0 1 1 1 1 Rio2, N-terminal APH PF01636.23 EDO15013.1 - 3.3e-05 23.9 0.7 0.31 10.9 1.1 2.8 2 1 1 3 3 3 2 Phosphotransferase enzyme family Kdo PF06293.14 EDO15013.1 - 0.00022 20.7 0.4 0.028 13.8 0.1 2.4 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EDO15013.1 - 0.013 14.3 0.0 0.018 13.8 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase Cwf_Cwc_15 PF04889.12 EDO15013.1 - 1.4 8.6 10.3 2.4 7.8 10.3 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Pes-10 PF07149.11 EDO15013.1 - 8.5 5.3 7.2 16 4.4 7.2 1.4 1 0 0 1 1 1 0 Pes-10 Rick_17kDa_Anti PF05433.15 EDO15014.1 - 3.5e-09 36.4 5.9 5e-09 35.9 5.9 1.2 1 0 0 1 1 1 1 Glycine zipper 2TM domain Gly-zipper_Omp PF13488.6 EDO15014.1 - 8e-06 25.8 5.0 1.5e-05 24.9 5.0 1.4 1 0 0 1 1 1 1 Glycine zipper DUF2076 PF09849.9 EDO15014.1 - 0.035 14.1 27.7 1.1 9.2 27.7 2.0 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) Pex14_N PF04695.13 EDO15014.1 - 0.46 11.1 14.6 0.62 10.7 14.3 1.4 1 1 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region PT-VENN PF04829.13 EDO15014.1 - 0.47 10.6 4.1 0.84 9.8 4.1 1.4 1 0 0 1 1 1 0 Pre-toxin domain with VENN motif Bacteriocin_IIc PF10439.9 EDO15014.1 - 1 9.5 8.3 1.8 8.8 8.3 1.3 1 0 0 1 1 1 0 Bacteriocin class II with double-glycine leader peptide Lin-8 PF03353.15 EDO15014.1 - 1.1 8.7 6.6 1.2 8.6 6.6 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Trep_Strep PF09605.10 EDO15014.1 - 1.6 8.7 3.3 1.7 8.6 0.3 1.9 1 1 1 2 2 2 0 Hypothetical bacterial integral membrane protein (Trep_Strep) Gly-zipper_YMGG PF13441.6 EDO15014.1 - 1.6 8.5 15.7 1.5 8.6 3.2 1.9 1 1 2 3 3 3 0 YMGG-like Gly-zipper Aldo_ket_red PF00248.21 EDO15015.1 - 5.7e-62 209.6 0.0 6.5e-62 209.4 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family HTH_40 PF14493.6 EDO15015.1 - 0.03 14.8 0.0 0.097 13.1 0.0 1.8 1 0 0 1 1 1 0 Helix-turn-helix domain Flocculin PF00624.18 EDO15016.1 - 2.6e-14 53.2 45.9 9e-11 41.8 25.4 4.3 5 0 0 5 5 5 2 Flocculin repeat Period_C PF12114.8 EDO15016.1 - 0.28 10.7 3.5 0.4 10.2 3.5 1.2 1 0 0 1 1 1 0 Period protein 2/3C-terminal region GspH PF12019.8 EDO15016.1 - 6.6 7.2 7.1 4.3 7.8 0.4 2.7 1 1 1 2 2 2 0 Type II transport protein GspH Flocculin PF00624.18 EDO15017.1 - 1.9e-16 60.0 60.0 7.6e-12 45.3 31.8 5.8 5 1 1 6 6 6 2 Flocculin repeat Exo_endo_phos PF03372.23 EDO15018.1 - 1.6e-10 40.9 0.0 3.5e-10 39.8 0.0 1.6 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family zf-GRF PF06839.12 EDO15018.1 - 2.7e-10 40.2 0.9 6.4e-10 39.0 0.9 1.7 1 0 0 1 1 1 1 GRF zinc finger Exo_endo_phos_2 PF14529.6 EDO15018.1 - 7.8e-06 25.7 0.1 0.041 13.7 0.0 2.5 2 0 0 2 2 2 2 Endonuclease-reverse transcriptase Epimerase PF01370.21 EDO15018.1 - 0.097 12.1 0.0 0.2 11.1 0.0 1.4 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Rft-1 PF04506.13 EDO15019.1 - 8.8e-217 720.9 44.0 1e-216 720.7 44.0 1.0 1 0 0 1 1 1 1 Rft protein Phlebovirus_G2 PF07245.11 EDO15019.1 - 0.18 10.3 1.9 0.11 10.9 0.1 1.5 2 0 0 2 2 2 0 Phlebovirus glycoprotein G2 CBFD_NFYB_HMF PF00808.23 EDO15020.1 - 3.6e-25 88.0 0.1 5.9e-25 87.3 0.1 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EDO15020.1 - 3.8e-07 30.5 0.1 4.6e-07 30.2 0.1 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 PAN_3 PF08277.12 EDO15020.1 - 0.0085 15.9 0.7 0.013 15.3 0.7 1.3 1 0 0 1 1 1 1 PAN-like domain CENP-T_C PF15511.6 EDO15020.1 - 0.015 15.5 0.0 0.018 15.1 0.0 1.2 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T histone fold TFIID_20kDa PF03847.13 EDO15020.1 - 0.055 14.0 0.1 0.11 13.0 0.1 1.5 1 0 0 1 1 1 0 Transcription initiation factor TFIID subunit A Bromo_TP PF07524.13 EDO15020.1 - 0.1 12.6 0.0 0.7 9.9 0.0 2.1 2 1 0 2 2 2 0 Bromodomain associated SAM_PNT PF02198.16 EDO15020.1 - 0.13 12.3 0.0 0.17 11.8 0.0 1.2 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain NAD_Gly3P_dh_N PF01210.23 EDO15020.1 - 0.14 12.2 0.0 0.15 12.0 0.0 1.1 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus LON_substr_bdg PF02190.16 EDO15021.1 - 1e-19 71.3 0.4 1e-19 71.3 0.4 1.6 2 0 0 2 2 2 1 ATP-dependent protease La (LON) substrate-binding domain Mem_trans PF03547.18 EDO15021.1 - 3.1 6.1 3.9 0.49 8.7 0.2 1.5 2 0 0 2 2 2 0 Membrane transport protein DUF2407_C PF13373.6 EDO15021.1 - 5.5 7.2 7.6 22 5.2 7.6 2.1 1 1 0 1 1 1 0 DUF2407 C-terminal domain Lon_C PF05362.13 EDO15022.1 - 6.6e-66 221.8 0.0 1.8e-65 220.4 0.0 1.7 2 0 0 2 2 2 1 Lon protease (S16) C-terminal proteolytic domain AAA PF00004.29 EDO15022.1 - 5.8e-23 81.8 0.0 1.7e-22 80.3 0.0 1.9 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) AAA_2 PF07724.14 EDO15022.1 - 2.8e-07 30.8 0.0 1.2e-06 28.7 0.0 2.1 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) ChlI PF13541.6 EDO15022.1 - 9.2e-06 25.5 0.0 1.9e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 Subunit ChlI of Mg-chelatase AAA_5 PF07728.14 EDO15022.1 - 4.1e-05 23.6 0.0 0.00014 21.9 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EDO15022.1 - 6.5e-05 23.2 0.1 0.002 18.4 0.1 2.6 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.12 EDO15022.1 - 0.00016 21.4 0.0 0.0017 18.2 0.0 2.6 3 0 0 3 3 3 1 Holliday junction DNA helicase RuvB P-loop domain AAA_PrkA PF08298.11 EDO15022.1 - 0.00022 20.2 0.0 0.00053 19.0 0.0 1.5 1 0 0 1 1 1 1 PrkA AAA domain AAA_14 PF13173.6 EDO15022.1 - 0.00077 19.5 0.1 0.0094 16.0 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 EDO15022.1 - 0.00078 20.0 0.3 0.0062 17.1 0.0 2.7 3 0 0 3 3 2 1 AAA domain AAA_16 PF13191.6 EDO15022.1 - 0.0015 18.9 0.1 0.0075 16.7 0.1 2.1 1 1 1 2 2 2 1 AAA ATPase domain IstB_IS21 PF01695.17 EDO15022.1 - 0.0024 17.7 0.0 0.0053 16.5 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein ClpB_D2-small PF10431.9 EDO15022.1 - 0.015 15.4 0.7 0.04 14.0 0.0 2.1 2 0 0 2 2 1 0 C-terminal, D2-small domain, of ClpB protein RsgA_GTPase PF03193.16 EDO15022.1 - 0.015 15.2 0.0 0.056 13.3 0.0 1.9 2 0 0 2 2 1 0 RsgA GTPase RecG_wedge PF17191.4 EDO15022.1 - 0.018 14.7 0.2 0.034 13.8 0.2 1.4 1 0 0 1 1 1 0 RecG wedge domain RNA_helicase PF00910.22 EDO15022.1 - 0.02 15.3 0.1 0.086 13.2 0.0 2.1 2 0 0 2 2 2 0 RNA helicase TIP49 PF06068.13 EDO15022.1 - 0.033 13.4 1.1 0.059 12.6 0.1 1.9 2 0 0 2 2 1 0 TIP49 P-loop domain TsaE PF02367.17 EDO15022.1 - 0.034 14.1 0.0 0.084 12.9 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE SKI PF01202.22 EDO15022.1 - 0.039 14.1 0.0 0.12 12.5 0.0 1.8 1 0 0 1 1 1 0 Shikimate kinase NB-ARC PF00931.22 EDO15022.1 - 0.046 12.9 0.1 0.095 11.9 0.1 1.4 1 0 0 1 1 1 0 NB-ARC domain Viral_helicase1 PF01443.18 EDO15022.1 - 0.047 13.4 0.0 0.11 12.2 0.0 1.6 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase AAA_7 PF12775.7 EDO15022.1 - 0.048 13.2 0.1 0.11 12.0 0.1 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region Clr2 PF10383.9 EDO15022.1 - 0.056 14.2 0.1 0.12 13.2 0.1 1.5 1 0 0 1 1 1 0 Transcription-silencing protein Clr2 AAA_3 PF07726.11 EDO15022.1 - 0.083 12.8 0.0 0.18 11.7 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) NTPase_1 PF03266.15 EDO15022.1 - 0.12 12.3 0.5 1.3 8.9 0.1 2.5 1 1 1 2 2 2 0 NTPase AAA_30 PF13604.6 EDO15022.1 - 0.16 11.7 0.0 0.34 10.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain RasGAP PF00616.19 EDO15022.1 - 0.19 11.4 3.4 0.31 10.7 0.5 2.1 2 0 0 2 2 2 0 GTPase-activator protein for Ras-like GTPase ABC_tran PF00005.27 EDO15022.1 - 0.2 12.2 1.2 0.49 10.9 0.1 2.2 2 0 0 2 2 1 0 ABC transporter DNTTIP1_dimer PF18192.1 EDO15022.1 - 0.77 10.2 5.1 5.1 7.5 0.6 2.9 3 0 0 3 3 2 0 DNTTIP1 dimerisation domain zf-UBR PF02207.20 EDO15023.1 - 6.3e-10 39.1 9.1 6.3e-10 39.1 9.1 2.5 3 0 0 3 3 3 1 Putative zinc finger in N-recognin (UBR box) zf-AD PF07776.15 EDO15023.1 - 0.022 15.0 2.8 0.025 14.8 0.0 2.5 2 0 0 2 2 2 0 Zinc-finger associated domain (zf-AD) PHD PF00628.29 EDO15023.1 - 5.7 6.9 25.0 0.4 10.6 9.0 3.2 2 1 0 2 2 2 0 PHD-finger MCM PF00493.23 EDO15024.1 - 2.7e-103 343.9 0.1 4.1e-103 343.3 0.1 1.2 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 EDO15024.1 - 3.5e-37 127.0 0.0 6.4e-37 126.2 0.0 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 EDO15024.1 - 2.2e-26 92.1 0.1 5.4e-26 90.8 0.1 1.7 1 0 0 1 1 1 1 MCM AAA-lid domain MCM2_N PF12619.8 EDO15024.1 - 2.2e-24 86.5 31.3 2.2e-24 86.5 31.3 4.2 5 0 0 5 5 5 1 Mini-chromosome maintenance protein 2 MCM_N PF14551.6 EDO15024.1 - 1e-11 45.3 0.0 3.9e-11 43.5 0.0 2.0 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 EDO15024.1 - 2.6e-09 36.8 0.0 2.1e-07 30.5 0.0 2.4 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 EDO15024.1 - 2.7e-07 30.7 0.0 6e-07 29.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 EDO15024.1 - 0.00072 19.4 0.0 0.0057 16.5 0.0 2.2 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 EDO15024.1 - 0.0023 17.7 0.1 0.013 15.2 0.1 2.0 1 1 0 1 1 1 1 Sigma-54 interaction domain AAA PF00004.29 EDO15024.1 - 0.023 15.1 0.0 0.072 13.5 0.0 1.9 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 EDO15024.1 - 0.052 13.3 0.1 0.098 12.4 0.1 1.3 1 0 0 1 1 1 0 AAA domain SelR PF01641.18 EDO15024.1 - 0.058 13.5 0.0 2.6 8.1 0.1 2.3 2 0 0 2 2 2 0 SelR domain Ribosomal_L27A PF00828.19 EDO15025.1 - 5.1e-33 114.5 0.6 9.6e-33 113.6 0.6 1.5 1 0 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A DEAD PF00270.29 EDO15026.1 - 7e-45 152.9 1.9 1.1e-44 152.4 0.6 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDO15026.1 - 1.3e-28 99.6 0.4 1.9e-27 95.8 0.0 2.5 2 1 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDO15026.1 - 2e-08 34.4 1.3 2.4e-07 30.9 0.0 2.6 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit CMS1 PF14617.6 EDO15026.1 - 0.019 14.3 0.3 0.051 12.9 0.3 1.7 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit MFAP1 PF06991.11 EDO15026.1 - 0.043 13.7 1.1 0.082 12.7 1.1 1.5 1 0 0 1 1 1 0 Microfibril-associated/Pre-mRNA processing ERCC4 PF02732.15 EDO15027.1 - 1e-22 81.0 0.9 3.2e-22 79.4 0.0 2.4 2 0 0 2 2 2 1 ERCC4 domain MTHFR PF02219.17 EDO15028.1 - 2.3e-110 368.5 0.0 2.9e-110 368.1 0.0 1.1 1 0 0 1 1 1 1 Methylenetetrahydrofolate reductase RMI1_N PF08585.12 EDO15029.1 - 1.6e-22 80.3 0.1 2.2e-22 79.9 0.1 1.2 1 0 0 1 1 1 1 RecQ mediated genome instability protein Spo7_2_N PF15407.6 EDO15029.1 - 0.019 14.6 0.0 0.052 13.2 0.0 1.7 1 0 0 1 1 1 0 Sporulation protein family 7 IGR PF09597.10 EDO15029.1 - 0.056 13.6 0.2 0.12 12.5 0.2 1.6 1 0 0 1 1 1 0 IGR protein motif Sybindin PF04099.12 EDO15030.1 - 3.4e-37 127.5 6.5 2e-15 56.9 0.5 3.2 3 0 0 3 3 3 3 Sybindin-like family Sedlin_N PF04628.13 EDO15030.1 - 3.3e-08 33.7 1.6 3.3e-08 33.7 1.6 1.8 2 0 0 2 2 2 1 Sedlin, N-terminal conserved region Thiolase_N PF00108.23 EDO15031.1 - 9.6e-94 313.6 1.2 1.3e-93 313.1 1.2 1.2 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 EDO15031.1 - 1.6e-45 153.7 0.3 4.4e-45 152.3 0.3 1.8 1 0 0 1 1 1 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 EDO15031.1 - 1.4e-05 24.9 0.2 3.2e-05 23.6 0.2 1.7 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III PF08545.10 EDO15031.1 - 0.16 11.9 1.8 1.6 8.6 0.2 2.6 3 0 0 3 3 3 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III AdoMet_MTase PF07757.13 EDO15032.1 - 2.1e-41 140.7 0.2 3.8e-41 139.9 0.2 1.4 1 0 0 1 1 1 1 Predicted AdoMet-dependent methyltransferase Methyltransf_31 PF13847.6 EDO15032.1 - 0.0028 17.4 0.1 0.0058 16.4 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase domain MetW PF07021.12 EDO15032.1 - 0.054 13.1 0.0 0.12 12.0 0.0 1.5 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW Methyltransf_32 PF13679.6 EDO15032.1 - 0.1 12.6 0.1 4.5 7.2 0.0 2.4 2 0 0 2 2 2 0 Methyltransferase domain Pkinase PF00069.25 EDO15033.1 - 1.6e-76 257.2 0.0 1.8e-76 257.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO15033.1 - 2.5e-37 128.6 0.0 3.4e-37 128.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EDO15033.1 - 0.0036 16.3 0.1 0.014 14.3 0.1 1.9 1 1 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 EDO15033.1 - 0.038 13.9 0.0 0.2 11.6 0.0 2.0 2 0 0 2 2 2 0 Phosphotransferase enzyme family Kinase-like PF14531.6 EDO15033.1 - 0.054 12.8 0.1 0.072 12.4 0.1 1.5 1 1 0 1 1 1 0 Kinase-like ANAPC4 PF12896.7 EDO15034.1 - 1.5e-27 96.4 0.6 2.2e-27 95.9 0.6 1.2 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 4 ANAPC4_WD40 PF12894.7 EDO15034.1 - 0.01 16.1 0.0 0.023 15.0 0.0 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain SUI1 PF01253.22 EDO15035.1 - 3.7e-18 65.8 0.0 8.6e-18 64.6 0.0 1.7 1 0 0 1 1 1 1 Translation initiation factor SUI1 Pre-PUA PF17832.1 EDO15035.1 - 5.9e-10 39.7 0.3 2e-09 38.0 0.3 2.0 1 0 0 1 1 1 1 Pre-PUA-like domain SWIB PF02201.18 EDO15035.1 - 0.0035 17.2 0.2 0.0081 16.0 0.2 1.6 1 0 0 1 1 1 1 SWIB/MDM2 domain Kin17_mid PF10357.9 EDO15035.1 - 0.005 16.8 1.4 0.0078 16.1 0.4 1.8 2 0 0 2 2 2 1 Domain of Kin17 curved DNA-binding protein Ribosomal_L1 PF00687.21 EDO15036.1 - 2.4e-31 109.1 0.9 3.1e-31 108.7 0.9 1.2 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family RcpB PF16971.5 EDO15036.1 - 0.043 13.7 1.5 2 8.3 0.1 2.4 1 1 1 2 2 2 0 Rough colony protein B, tight adherence - tad - subunit GEP5 PF17053.5 EDO15037.1 - 1.8e-69 234.0 7.7 2.3e-69 233.7 7.7 1.1 1 0 0 1 1 1 1 Genetic interactor of prohibitin 5 PHAT PF09246.10 EDO15037.1 - 0.0049 16.7 0.6 0.016 15.0 0.0 2.1 2 0 0 2 2 2 1 PHAT KNOX2 PF03791.13 EDO15037.1 - 0.17 11.4 0.1 2.8 7.5 0.0 2.3 2 0 0 2 2 2 0 KNOX2 domain Aminotran_1_2 PF00155.21 EDO15038.1 - 8.1e-39 133.8 0.0 1.2e-38 133.3 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 EDO15038.1 - 0.0041 16.4 0.0 0.0094 15.3 0.0 1.6 2 0 0 2 2 2 1 Beta-eliminating lyase YccV-like PF08755.11 EDO15040.1 - 0.027 15.0 0.2 0.13 12.7 0.1 2.3 2 0 0 2 2 2 0 Hemimethylated DNA-binding protein YccV like SMC_N PF02463.19 EDO15041.1 - 4.7e-64 215.8 62.5 9e-63 211.6 62.5 2.9 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 EDO15041.1 - 6.5e-22 78.0 0.0 2.5e-21 76.2 0.0 2.1 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 EDO15041.1 - 9.8e-08 32.2 25.9 3.5e-05 23.8 1.0 4.8 3 2 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 EDO15041.1 - 1.3e-06 29.1 22.1 1.3e-06 29.1 22.1 8.0 3 2 2 6 6 6 1 AAA domain AAA_29 PF13555.6 EDO15041.1 - 0.00065 19.4 0.0 0.0013 18.4 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_15 PF13175.6 EDO15041.1 - 0.0034 17.1 28.9 0.0034 17.1 28.9 4.8 2 2 2 4 4 4 1 AAA ATPase domain DUF2852 PF11014.8 EDO15041.1 - 0.055 13.6 0.1 0.055 13.6 0.1 4.5 4 0 0 4 4 4 0 Protein of unknown function (DUF2852) SbcCD_C PF13558.6 EDO15041.1 - 0.09 13.0 0.0 1.4 9.2 0.0 2.5 2 0 0 2 2 2 0 Putative exonuclease SbcCD, C subunit ABC_tran PF00005.27 EDO15041.1 - 1.4 9.5 0.0 1.4 9.5 0.0 6.4 4 1 0 4 4 4 0 ABC transporter FGGY_C PF02782.16 EDO15042.1 - 1.5e-47 161.9 0.0 2.2e-47 161.3 0.0 1.2 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.21 EDO15042.1 - 5.1e-24 85.2 0.1 4.2e-23 82.2 0.1 2.2 1 1 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain Hexokinase_1 PF00349.21 EDO15042.1 - 0.008 16.1 0.0 0.014 15.3 0.0 1.4 1 0 0 1 1 1 1 Hexokinase AnmK PF03702.14 EDO15042.1 - 0.074 12.2 0.0 0.21 10.6 0.0 1.6 2 0 0 2 2 2 0 Anhydro-N-acetylmuramic acid kinase BcrAD_BadFG PF01869.20 EDO15042.1 - 0.12 11.9 2.3 0.35 10.3 1.7 2.1 2 1 0 2 2 2 0 BadF/BadG/BcrA/BcrD ATPase family DEDD_Tnp_IS110 PF01548.17 EDO15042.1 - 0.19 11.6 0.0 0.4 10.6 0.0 1.5 1 0 0 1 1 1 0 Transposase Rax2 PF12768.7 EDO15043.1 - 3.3e-54 183.6 7.5 3.3e-54 183.6 7.5 5.5 6 0 0 6 6 6 2 Cortical protein marker for cell polarity TRAPPC-Trs85 PF12739.7 EDO15044.1 - 1.8e-109 366.4 5.2 1.8e-109 366.4 5.2 1.7 2 0 0 2 2 2 1 ER-Golgi trafficking TRAPP I complex 85 kDa subunit RPN7 PF10602.9 EDO15044.1 - 0.0054 16.4 1.5 1.2 8.8 0.2 2.8 3 0 0 3 3 3 2 26S proteasome subunit RPN7 COPIIcoated_ERV PF07970.12 EDO15046.1 - 1.3e-76 257.3 0.8 1.9e-76 256.8 0.8 1.2 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 EDO15046.1 - 3.5e-26 91.4 0.3 7.5e-26 90.3 0.3 1.6 1 0 0 1 1 1 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) CDC24 PF06395.11 EDO15047.1 - 4.8e-36 122.9 0.8 1.4e-35 121.4 0.8 1.9 1 0 0 1 1 1 1 CDC24 Calponin PH_10 PF15411.6 EDO15047.1 - 1.1e-31 109.7 0.8 3.9e-31 107.9 0.8 2.1 1 0 0 1 1 1 1 Pleckstrin homology domain RhoGEF PF00621.20 EDO15047.1 - 2.5e-29 102.8 5.7 2.5e-29 102.8 5.7 2.9 4 0 0 4 4 4 1 RhoGEF domain PB1 PF00564.24 EDO15047.1 - 5.9e-06 26.1 0.8 2.3e-05 24.3 0.4 2.2 2 0 0 2 2 2 1 PB1 domain PH PF00169.29 EDO15047.1 - 0.12 12.8 3.9 0.38 11.3 2.4 2.7 2 1 0 2 2 2 0 PH domain DUF5563 PF17718.1 EDO15048.1 - 0.34 10.5 3.8 6.8 6.2 0.0 3.1 2 1 0 3 3 3 0 Family of unknown function (DUF5563) Cupin_8 PF13621.6 EDO15049.1 - 9.6e-43 146.7 0.0 1.1e-41 143.2 0.0 2.2 1 1 0 1 1 1 1 Cupin-like domain JmjC PF02373.22 EDO15049.1 - 0.017 15.6 0.0 0.088 13.2 0.0 2.2 2 0 0 2 2 2 0 JmjC domain, hydroxylase Cupin_4 PF08007.12 EDO15049.1 - 0.031 13.7 0.0 0.43 10.0 0.0 2.4 2 0 0 2 2 2 0 Cupin superfamily protein Cyclin_N PF00134.23 EDO15050.1 - 1.6e-25 89.3 0.9 4.7e-25 87.8 0.9 1.8 1 0 0 1 1 1 1 Cyclin, N-terminal domain DUF2291 PF10054.9 EDO15050.1 - 0.071 12.8 2.1 0.13 12.0 2.1 1.3 1 0 0 1 1 1 0 Predicted periplasmic lipoprotein (DUF2291) Cdc13_OB2 PF18691.1 EDO15051.1 - 0.032 14.3 0.9 0.15 12.1 0.9 2.2 1 0 0 1 1 1 0 Cell division control protein 13, OB2 domain HEAT_EZ PF13513.6 EDO15051.1 - 0.33 11.5 1.0 28 5.3 0.0 3.2 3 0 0 3 3 3 0 HEAT-like repeat AA_permease PF00324.21 EDO15052.1 - 2.4e-136 455.1 41.1 2.8e-136 454.9 41.1 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EDO15052.1 - 2.2e-23 82.8 44.9 2.8e-23 82.5 44.9 1.1 1 0 0 1 1 1 1 Amino acid permease TMEM252 PF15664.5 EDO15052.1 - 0.096 12.4 0.3 0.25 11.1 0.3 1.6 1 0 0 1 1 1 0 Transmembrane protein 252 family NCE101 PF11654.8 EDO15052.1 - 1.2 8.9 3.1 1.6 8.5 0.1 2.4 2 0 0 2 2 2 0 Non-classical export protein 1 PK PF00224.21 EDO15053.1 - 1.9e-161 536.8 0.0 2.4e-161 536.4 0.0 1.1 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.16 EDO15053.1 - 2e-36 124.7 0.0 5.6e-36 123.3 0.0 1.8 1 0 0 1 1 1 1 Pyruvate kinase, alpha/beta domain HpcH_HpaI PF03328.14 EDO15053.1 - 1.7e-05 24.1 0.2 4.8e-05 22.6 0.1 1.7 1 1 0 2 2 2 1 HpcH/HpaI aldolase/citrate lyase family IMS PF00817.20 EDO15054.1 - 1.9e-24 86.4 0.0 3.9e-24 85.4 0.0 1.5 1 0 0 1 1 1 1 impB/mucB/samB family BRCT_2 PF16589.5 EDO15054.1 - 2.8e-14 53.3 0.1 2.2e-13 50.4 0.0 2.6 2 0 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain IMS_C PF11799.8 EDO15054.1 - 9.9e-10 39.1 0.0 3e-09 37.6 0.0 1.8 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain BRCT PF00533.26 EDO15054.1 - 1.1e-09 38.5 2.6 1.4e-09 38.2 0.1 2.6 2 1 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain LIG3_BRCT PF16759.5 EDO15054.1 - 9.4e-07 29.0 0.0 2.8e-06 27.5 0.0 1.8 1 0 0 1 1 1 1 DNA ligase 3 BRCT domain REV1_C PF16727.5 EDO15054.1 - 4.9e-05 23.6 0.0 0.0001 22.6 0.0 1.5 1 0 0 1 1 1 1 DNA repair protein REV1 C-terminal domain PTCB-BRCT PF12738.7 EDO15054.1 - 0.00097 19.0 0.0 0.0023 17.8 0.0 1.7 1 0 0 1 1 1 1 twin BRCT domain Whi5 PF08528.11 EDO15054.1 - 5.6 6.7 5.6 9.8 5.9 0.5 3.1 3 0 0 3 3 3 0 Whi5 like HLH PF00010.26 EDO15055.1 - 4.5e-21 74.6 0.1 1.3e-20 73.1 0.1 1.8 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain AAA_17 PF13207.6 EDO15055.1 - 0.023 15.1 0.1 0.053 13.9 0.0 1.6 1 1 0 1 1 1 0 AAA domain PBECR1 PF18809.1 EDO15055.1 - 1.2 9.9 5.3 0.26 12.0 0.4 2.3 2 1 0 2 2 2 0 phage-Barnase-EndoU-ColicinE5/D-RelE like nuclease1 zf-CCHC PF00098.23 EDO15056.1 - 2e-05 24.4 16.3 0.0012 18.8 3.5 5.7 7 0 0 7 7 7 3 Zinc knuckle Mfp-3 PF04202.13 EDO15056.1 - 0.9 10.0 8.6 2.9 8.3 8.6 2.0 1 0 0 1 1 1 0 Foot protein 3 tRNA-synt_2b PF00587.25 EDO15057.1 - 1.2e-36 126.4 0.0 2e-36 125.6 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 EDO15057.1 - 3.7e-20 71.9 0.4 8.1e-20 70.8 0.4 1.6 1 0 0 1 1 1 1 Anticodon binding domain TGS PF02824.21 EDO15057.1 - 3e-14 52.8 0.0 6.1e-14 51.8 0.0 1.5 1 0 0 1 1 1 1 TGS domain tRNA_SAD PF07973.14 EDO15057.1 - 1.2e-12 47.7 0.0 2.5e-12 46.7 0.0 1.6 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain Coatomer_E PF04733.14 EDO15058.1 - 1.1e-06 28.4 10.1 2.6e-05 23.8 10.1 2.4 1 1 0 1 1 1 1 Coatomer epsilon subunit TPR_19 PF14559.6 EDO15058.1 - 0.00012 22.5 0.9 0.29 11.7 0.0 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 EDO15058.1 - 0.003 17.5 0.1 8.5 6.8 0.1 3.9 3 0 0 3 3 3 1 Tetratricopeptide repeat RPN6_N PF18055.1 EDO15058.1 - 0.032 14.6 0.5 0.032 14.6 0.5 2.4 3 0 0 3 3 3 0 26S proteasome regulatory subunit RPN6 N-terminal domain TarH PF02203.15 EDO15058.1 - 0.041 13.8 0.4 0.041 13.8 0.4 1.8 2 0 0 2 2 2 0 Tar ligand binding domain homologue SesA PF17107.5 EDO15058.1 - 0.065 13.4 0.6 2 8.6 0.1 2.5 2 0 0 2 2 2 0 N-terminal domain on NACHT_NTPase and P-loop NTPases TPR_4 PF07721.14 EDO15058.1 - 0.1 13.3 0.0 12 6.8 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.28 EDO15058.1 - 0.11 12.3 0.6 49 4.0 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat GET2 PF08690.10 EDO15059.1 - 2.2e-99 333.0 3.0 2.5e-99 332.8 3.0 1.0 1 0 0 1 1 1 1 GET complex subunit GET2 DUF1179 PF06678.11 EDO15059.1 - 0.035 14.1 2.9 0.093 12.7 2.9 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1179) 2-Hacid_dh_C PF02826.19 EDO15060.1 - 8.1e-51 171.9 0.0 1.6e-50 170.9 0.0 1.5 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EDO15060.1 - 3.4e-38 130.3 0.0 4.4e-38 130.0 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 EDO15060.1 - 2.3e-05 24.6 0.2 8.8e-05 22.7 0.0 2.0 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase ACT PF01842.25 EDO15060.1 - 0.0018 18.0 0.0 0.0061 16.3 0.0 1.9 1 0 0 1 1 1 1 ACT domain AdoHcyase_NAD PF00670.21 EDO15060.1 - 0.0032 17.6 0.0 0.007 16.4 0.0 1.5 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain TcpS PF17456.2 EDO15060.1 - 0.042 13.9 0.5 0.13 12.4 0.5 1.7 1 0 0 1 1 1 0 Toxin-coregulated pilus protein S SPO22 PF08631.10 EDO15061.1 - 2.5e-59 201.0 20.5 1.2e-57 195.5 3.8 3.9 3 2 1 4 4 4 2 Meiosis protein SPO22/ZIP4 like MIT PF04212.18 EDO15061.1 - 0.00022 21.3 2.6 0.53 10.4 0.1 4.0 3 0 0 3 3 3 2 MIT (microtubule interacting and transport) domain TFIIE_beta PF02186.15 EDO15061.1 - 0.0074 16.6 0.3 0.071 13.4 0.0 2.8 2 0 0 2 2 2 1 TFIIE beta subunit core domain TPR_19 PF14559.6 EDO15061.1 - 0.055 14.0 0.6 0.66 10.5 0.1 2.7 1 1 1 2 2 2 0 Tetratricopeptide repeat DUF4059 PF13268.6 EDO15061.1 - 0.18 12.2 0.8 1.1 9.7 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF4059) Lipoprotein_9 PF03180.14 EDO15062.1 - 0.094 11.8 0.0 0.12 11.4 0.0 1.2 1 0 0 1 1 1 0 NLPA lipoprotein HORMA PF02301.18 EDO15063.1 - 1.4e-59 201.3 0.5 3.1e-59 200.1 0.5 1.6 1 0 0 1 1 1 1 HORMA domain PHD_2 PF13831.6 EDO15063.1 - 0.79 9.3 8.8 0.25 10.9 4.5 2.3 3 0 0 3 3 3 0 PHD-finger Peptidase_M24 PF00557.24 EDO15064.1 - 2.2e-55 187.6 0.0 3.3e-55 187.0 0.0 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.16 EDO15064.1 - 9.4e-37 125.5 0.0 2.2e-36 124.3 0.0 1.6 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain Yos1 PF08571.10 EDO15065.1 - 5.3e-32 109.9 2.0 5.9e-32 109.8 2.0 1.0 1 0 0 1 1 1 1 Yos1-like DUF3671 PF12420.8 EDO15065.1 - 0.11 12.5 0.3 0.15 12.2 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function Ribosomal_S24e PF01282.19 EDO15066.1 - 4e-35 119.6 0.1 6.4e-35 119.0 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein S24e LCCL PF03815.19 EDO15067.1 - 3.4e-09 36.7 0.2 6e-09 35.9 0.2 1.4 1 0 0 1 1 1 1 LCCL domain OppC_N PF12911.7 EDO15067.1 - 7.5 6.6 5.9 11 6.0 0.4 3.3 3 0 0 3 3 3 0 N-terminal TM domain of oligopeptide transport permease C Ribonuc_red_lgC PF02867.15 EDO15068.1 - 5.1e-185 616.0 0.0 6.4e-185 615.6 0.0 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, barrel domain Ribonuc_red_lgN PF00317.21 EDO15068.1 - 1.6e-24 85.7 0.1 4.2e-24 84.4 0.1 1.8 1 0 0 1 1 1 1 Ribonucleotide reductase, all-alpha domain ATP-cone PF03477.16 EDO15068.1 - 5.5e-19 68.5 0.0 2e-18 66.8 0.0 2.0 1 0 0 1 1 1 1 ATP cone domain Methyltransf_31 PF13847.6 EDO15069.1 - 9.5e-27 93.7 0.2 1.5e-26 93.0 0.2 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDO15069.1 - 5.6e-10 39.8 0.0 1.2e-09 38.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EDO15069.1 - 1.7e-08 35.1 0.1 3.5e-08 34.1 0.1 1.6 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_32 PF13679.6 EDO15069.1 - 1.5e-07 31.6 0.0 1.9e-07 31.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EDO15069.1 - 8e-07 29.6 0.0 1.3e-06 29.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 EDO15069.1 - 5.2e-06 26.0 0.1 6.7e-06 25.6 0.1 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase MTS PF05175.14 EDO15069.1 - 1.3e-05 24.8 0.0 2.2e-05 24.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_18 PF12847.7 EDO15069.1 - 2.7e-05 24.1 0.0 5.4e-05 23.2 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EDO15069.1 - 3.2e-05 23.8 0.0 5.1e-05 23.2 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_20 PF12147.8 EDO15069.1 - 0.00039 19.7 0.1 0.0011 18.2 0.0 1.6 1 1 1 2 2 2 1 Putative methyltransferase MetW PF07021.12 EDO15069.1 - 0.0013 18.4 0.0 0.002 17.8 0.0 1.3 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_4 PF02390.17 EDO15069.1 - 0.0016 18.0 0.0 0.0029 17.1 0.0 1.4 1 0 0 1 1 1 1 Putative methyltransferase PrmA PF06325.13 EDO15069.1 - 0.034 13.5 0.0 0.052 12.9 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) P16-Arc PF04699.14 EDO15070.1 - 2e-48 164.6 0.0 2.3e-48 164.5 0.0 1.0 1 0 0 1 1 1 1 ARP2/3 complex 16 kDa subunit (p16-Arc) Sigma70_r4_2 PF08281.12 EDO15070.1 - 0.038 13.7 0.0 0.087 12.5 0.0 1.6 1 0 0 1 1 1 0 Sigma-70, region 4 NAT PF04768.13 EDO15071.1 - 1.5e-56 190.7 1.3 2.3e-56 190.1 0.3 1.8 2 0 0 2 2 2 1 NAT, N-acetyltransferase, of N-acetylglutamate synthase AA_kinase PF00696.28 EDO15071.1 - 1.6e-23 83.5 0.0 6.1e-23 81.7 0.0 1.8 2 0 0 2 2 2 1 Amino acid kinase family zf-RING_4 PF14570.6 EDO15072.1 - 8.9e-20 70.2 13.0 1.7e-19 69.4 13.0 1.5 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-C3HC4_3 PF13920.6 EDO15072.1 - 2.8e-06 27.1 7.9 2.8e-06 27.1 7.9 1.7 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) RRM_1 PF00076.22 EDO15072.1 - 6.8e-06 25.8 0.2 0.0001 22.0 0.2 2.5 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Rtf2 PF04641.12 EDO15072.1 - 3e-05 23.5 26.5 0.00012 21.5 2.0 2.5 2 0 0 2 2 2 2 Rtf2 RING-finger Baculo_IE-1 PF05290.11 EDO15072.1 - 3.9e-05 23.6 3.8 3.9e-05 23.6 3.8 3.0 3 1 1 4 4 2 1 Baculovirus immediate-early protein (IE-0) zf-RING_2 PF13639.6 EDO15072.1 - 8.8e-05 22.8 9.6 0.00017 21.8 9.6 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 EDO15072.1 - 0.0023 17.7 10.6 0.0052 16.6 10.6 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) SET_assoc PF11767.8 EDO15072.1 - 0.0025 17.4 0.1 0.0081 15.8 0.0 1.8 2 0 0 2 2 1 1 Histone lysine methyltransferase SET associated Sin_N PF04801.13 EDO15072.1 - 0.0027 17.0 27.2 0.0027 17.0 27.2 1.6 2 0 0 2 2 1 1 Sin-like protein conserved region Prok-RING_4 PF14447.6 EDO15072.1 - 0.0035 17.2 8.7 0.09 12.7 9.2 2.4 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 AP3D1 PF06375.11 EDO15072.1 - 0.016 15.5 11.9 0.016 15.5 11.9 3.4 3 1 1 4 4 2 0 AP-3 complex subunit delta-1 FYDLN_acid PF09538.10 EDO15072.1 - 0.047 14.4 14.2 1.3 9.8 7.0 2.8 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) zf-RING_5 PF14634.6 EDO15072.1 - 0.07 13.1 9.7 0.18 11.8 9.7 1.8 1 0 0 1 1 1 0 zinc-RING finger domain zf-RING_UBOX PF13445.6 EDO15072.1 - 0.07 13.2 9.8 0.25 11.4 9.8 2.1 1 0 0 1 1 1 0 RING-type zinc-finger DUF4746 PF15928.5 EDO15072.1 - 0.078 12.4 14.9 0.036 13.5 10.9 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) CDC45 PF02724.14 EDO15072.1 - 0.092 11.0 16.9 0.015 13.7 10.9 2.2 2 0 0 2 2 2 0 CDC45-like protein Exonuc_VII_L PF02601.15 EDO15072.1 - 0.22 11.1 19.8 0.0062 16.1 13.5 1.8 2 0 0 2 2 1 0 Exonuclease VII, large subunit V_ATPase_I PF01496.19 EDO15072.1 - 0.27 9.1 24.6 0.035 12.1 20.2 1.6 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family RR_TM4-6 PF06459.12 EDO15072.1 - 0.27 11.0 26.7 0.067 13.0 18.7 2.5 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 DUF3807 PF12720.7 EDO15072.1 - 0.3 11.3 32.7 0.35 11.1 26.8 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3807) Phage_GPO PF05929.11 EDO15072.1 - 0.44 10.1 18.9 0.087 12.4 13.4 2.6 2 0 0 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase SpoIIP PF07454.11 EDO15072.1 - 0.51 9.8 24.8 0.079 12.4 19.1 2.3 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) DUF2126 PF09899.9 EDO15072.1 - 0.56 8.2 14.8 0.081 11.0 10.9 1.4 2 0 0 2 2 2 0 Putative amidoligase enzyme (DUF2126) SID-1_RNA_chan PF13965.6 EDO15072.1 - 0.63 8.4 8.5 1.2 7.5 8.5 1.4 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Cellulose_synt PF03552.14 EDO15072.1 - 0.64 8.4 6.2 1.2 7.5 6.2 1.4 1 0 0 1 1 1 0 Cellulose synthase RPN2_C PF18004.1 EDO15072.1 - 0.84 9.5 24.1 2.1 8.3 16.3 2.6 2 0 0 2 2 2 0 26S proteasome regulatory subunit RPN2 C-terminal domain Coilin_N PF15862.5 EDO15072.1 - 1.3 8.8 26.4 0.15 11.8 16.5 2.8 2 0 0 2 2 2 0 Coilin N-terminus TERB2 PF15101.6 EDO15072.1 - 1.8 8.6 31.5 2.1 8.3 27.5 2.7 2 0 0 2 2 2 0 Telomere-associated protein TERB2 PepSY_TM PF03929.16 EDO15072.1 - 2.1 8.0 17.0 5.1 6.7 14.9 2.2 2 0 0 2 2 2 0 PepSY-associated TM region zf-C3HC4_2 PF13923.6 EDO15072.1 - 2.4 8.1 9.6 5.2 7.0 9.6 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) PAT1 PF09770.9 EDO15072.1 - 2.6 6.2 50.2 5.5 5.1 50.2 1.5 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 EOS1 PF12326.8 EDO15072.1 - 2.7 7.9 14.8 2.1 8.3 9.6 2.6 3 0 0 3 3 2 0 N-glycosylation protein DUF1682 PF07946.14 EDO15072.1 - 2.7 7.1 20.8 0.15 11.2 9.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1682) DUF2072 PF09845.9 EDO15072.1 - 3 8.1 21.3 7.3 6.9 13.1 2.7 2 0 0 2 2 2 0 Zn-ribbon containing protein Pkinase_fungal PF17667.1 EDO15072.1 - 3 6.5 14.5 11 4.6 10.1 2.3 2 0 0 2 2 2 0 Fungal protein kinase CCDC84 PF14968.6 EDO15072.1 - 3 7.4 38.5 0.088 12.4 25.3 2.5 2 1 0 2 2 2 0 Coiled coil protein 84 ALMT PF11744.8 EDO15072.1 - 3 6.6 19.6 0.13 11.1 13.0 2.0 2 0 0 2 2 2 0 Aluminium activated malate transporter AAA_23 PF13476.6 EDO15072.1 - 3 8.3 31.8 0.96 9.9 24.9 2.5 2 0 0 2 2 2 0 AAA domain DUF2052 PF09747.9 EDO15072.1 - 3.1 7.9 27.9 5.8 7.0 21.7 2.4 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) PNISR PF15996.5 EDO15072.1 - 3.2 8.0 35.4 3.8 7.7 1.2 2.6 2 0 0 2 2 2 0 Arginine/serine-rich protein PNISR TAF4 PF05236.14 EDO15072.1 - 4.4 7.0 24.0 0.18 11.5 12.4 2.9 3 0 0 3 3 3 0 Transcription initiation factor TFIID component TAF4 family Connexin PF00029.19 EDO15072.1 - 5.6 6.7 23.6 4.4 7.0 18.2 2.2 2 0 0 2 2 2 0 Connexin Sec62 PF03839.16 EDO15072.1 - 6.4 6.2 23.3 5.2 6.5 17.6 2.4 2 0 0 2 2 2 0 Translocation protein Sec62 OATP PF03137.20 EDO15072.1 - 7.2 4.8 10.0 20 3.3 10.0 1.7 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Peptidase_S49_N PF08496.10 EDO15072.1 - 9 6.3 29.4 1.2 9.2 0.8 2.5 2 0 0 2 2 2 0 Peptidase family S49 N-terminal RGI1 PF10843.8 EDO15073.1 - 2.1e-34 118.9 9.9 3.6e-34 118.1 9.9 1.3 1 1 0 1 1 1 1 Respiratory growth induced protein 1 DIX PF00778.17 EDO15073.1 - 0.012 15.4 0.6 0.012 15.4 0.6 2.4 2 0 0 2 2 2 0 DIX domain Bac_rhodopsin PF01036.18 EDO15075.1 - 1.1e-45 156.0 15.7 1.5e-45 155.6 15.7 1.0 1 0 0 1 1 1 1 Bacteriorhodopsin-like protein DUF1772 PF08592.11 EDO15075.1 - 1.2 9.4 9.3 2.2 8.6 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1772) Snf7 PF03357.21 EDO15076.1 - 1.6e-34 119.0 10.6 2e-34 118.7 10.6 1.1 1 0 0 1 1 1 1 Snf7 SEA PF01390.20 EDO15076.1 - 0.061 13.4 0.2 0.16 12.1 0.1 1.8 2 0 0 2 2 2 0 SEA domain FOXP-CC PF16159.5 EDO15076.1 - 0.071 13.8 1.2 2.6 8.8 0.2 2.9 3 0 0 3 3 3 0 FOXP coiled-coil domain DASH_Duo1 PF08651.10 EDO15076.1 - 0.12 12.1 0.2 0.12 12.1 0.2 2.7 3 1 1 4 4 4 0 DASH complex subunit Duo1 DUF948 PF06103.11 EDO15076.1 - 0.29 11.4 3.4 0.42 10.9 0.9 2.4 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) DUF1640 PF07798.11 EDO15076.1 - 1.1 9.3 8.8 6.3 6.8 8.7 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF1640) DUF3573 PF12097.8 EDO15076.1 - 1.2 7.9 3.8 1.5 7.5 3.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) SlyX PF04102.12 EDO15076.1 - 1.8 9.2 9.3 1.8 9.2 1.2 3.1 3 1 1 4 4 4 0 SlyX Sec2p PF06428.11 EDO15076.1 - 9.6 6.2 15.7 7 6.7 0.9 3.9 2 1 2 4 4 4 0 GDP/GTP exchange factor Sec2p AAA PF00004.29 EDO15077.1 - 9.2e-11 42.3 0.1 6.8e-10 39.5 0.0 2.5 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 EDO15077.1 - 4e-05 23.6 0.1 4e-05 23.6 0.1 4.1 4 0 0 4 4 4 1 Rad17 P-loop domain RuvB_N PF05496.12 EDO15077.1 - 0.00017 21.4 0.0 0.00035 20.4 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_14 PF13173.6 EDO15077.1 - 0.00018 21.5 0.2 0.00018 21.5 0.2 3.7 3 1 2 5 5 5 1 AAA domain AAA_5 PF07728.14 EDO15077.1 - 0.0048 16.9 0.0 0.074 13.1 0.0 2.5 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EDO15077.1 - 0.0068 16.7 0.1 0.055 13.7 0.0 2.5 1 1 1 2 2 2 1 AAA domain AAA_16 PF13191.6 EDO15077.1 - 0.0076 16.6 0.0 0.014 15.8 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_33 PF13671.6 EDO15077.1 - 0.043 14.0 0.0 0.12 12.6 0.0 1.8 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EDO15077.1 - 0.062 13.7 5.2 0.48 10.8 0.1 4.1 3 2 0 3 3 3 0 RNA helicase IstB_IS21 PF01695.17 EDO15077.1 - 0.1 12.4 0.0 0.23 11.2 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein IPT PF01745.16 EDO15077.1 - 0.11 11.9 0.1 0.22 10.9 0.1 1.4 1 0 0 1 1 1 0 Isopentenyl transferase AAA_18 PF13238.6 EDO15077.1 - 0.3 11.6 0.0 0.3 11.6 0.0 5.8 4 3 1 6 6 6 0 AAA domain PIR PF00399.19 EDO15079.1 - 7.5e-16 57.2 26.4 1.3e-08 34.1 9.4 2.6 2 0 0 2 2 2 2 Yeast PIR protein repeat Utp11 PF03998.13 EDO15080.1 - 2.7e-68 230.6 38.8 3e-68 230.4 38.8 1.0 1 0 0 1 1 1 1 Utp11 protein ADH_N PF08240.12 EDO15081.1 - 5.6e-29 100.2 0.9 1.2e-28 99.1 0.9 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EDO15081.1 - 2.1e-26 92.4 0.4 3.5e-26 91.7 0.4 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EDO15081.1 - 5.6e-06 27.4 0.0 1e-05 26.6 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 EDO15081.1 - 0.0036 16.8 0.3 0.0053 16.3 0.3 1.2 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus Epimerase PF01370.21 EDO15081.1 - 0.095 12.1 0.1 0.14 11.6 0.1 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Copper-fist PF00649.18 EDO15081.1 - 0.27 10.7 1.4 0.52 9.8 1.4 1.4 1 0 0 1 1 1 0 Copper fist DNA binding domain Pkinase PF00069.25 EDO15082.1 - 5.2e-71 239.1 1.0 1.8e-64 217.7 0.0 2.6 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EDO15082.1 - 1.9e-36 125.7 0.0 1e-34 120.0 0.0 2.4 2 0 0 2 2 2 1 Protein tyrosine kinase APH PF01636.23 EDO15082.1 - 0.015 15.2 0.0 0.033 14.1 0.0 1.5 2 0 0 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.14 EDO15082.1 - 0.02 14.3 0.0 0.041 13.2 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Peptidase_M18 PF02127.15 EDO15083.1 - 4.8e-134 447.4 0.0 6.9e-134 446.9 0.0 1.2 1 0 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) SIS PF01380.22 EDO15084.1 - 2e-66 221.8 0.0 5.6e-34 116.8 0.1 2.3 2 0 0 2 2 2 2 SIS domain GATase_6 PF13522.6 EDO15084.1 - 1.9e-16 60.4 0.0 3.8e-16 59.5 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.6 EDO15084.1 - 1.6e-10 41.0 0.0 3.4e-10 39.9 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_4 PF13230.6 EDO15084.1 - 1.4e-05 24.1 0.0 2.5e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferases class-II COMPASS-Shg1 PF05205.12 EDO15084.1 - 0.094 13.4 0.0 0.3 11.8 0.0 1.9 1 0 0 1 1 1 0 COMPASS (Complex proteins associated with Set1p) component shg1 Flocculin PF00624.18 EDO15086.1 - 2.1e-144 469.5 472.4 1.3e-14 54.1 30.2 25.0 15 1 1 16 16 16 14 Flocculin repeat Flocculin PF00624.18 EDO15087.1 - 1.2e-21 76.6 78.8 4.1e-12 46.1 29.6 4.7 4 1 1 5 5 5 3 Flocculin repeat Putative_PNPOx PF01243.20 EDO15087.1 - 0.035 14.3 0.1 0.061 13.5 0.1 1.5 1 0 0 1 1 1 0 Pyridoxamine 5'-phosphate oxidase VCX_VCY PF15231.6 EDO15088.1 - 0.072 13.8 21.9 2 9.1 4.8 3.1 1 1 2 3 3 3 0 Variable charge X/Y family Autophagy_C PF10381.9 EDO15088.1 - 0.33 10.5 1.1 0.87 9.2 1.1 1.7 1 0 0 1 1 1 0 Autophagocytosis associated protein C-terminal Flocculin PF00624.18 EDO15089.1 - 3.8e-61 203.1 304.9 4.1e-10 39.8 18.1 35.9 33 1 2 35 35 35 17 Flocculin repeat MFS_1 PF07690.16 EDO15090.1 - 1.5e-07 30.7 44.9 7.6e-06 25.1 15.3 3.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EDO15090.1 - 3.8e-07 29.3 26.5 1.1e-06 27.9 5.1 3.1 2 1 1 3 3 3 2 Sugar (and other) transporter MFS_1 PF07690.16 EDO15091.1 - 5.7e-09 35.4 38.4 0.00037 19.5 17.5 2.7 1 1 1 2 2 2 2 Major Facilitator Superfamily Epimerase PF01370.21 EDO15092.1 - 1.9e-16 60.3 0.0 2.7e-16 59.8 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EDO15092.1 - 6.3e-12 45.1 0.1 9.7e-12 44.5 0.1 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 EDO15092.1 - 1.3e-07 31.4 0.2 1.4e-06 28.0 0.1 2.0 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 EDO15092.1 - 9.6e-07 28.2 0.2 1.1e-05 24.8 0.2 2.2 1 1 0 1 1 1 1 Male sterility protein Polysacc_synt_2 PF02719.15 EDO15092.1 - 1.1e-06 28.0 0.1 3.6e-05 23.1 0.1 2.3 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.6 EDO15092.1 - 1.1e-05 25.4 0.0 2.6e-05 24.2 0.0 1.7 2 0 0 2 2 2 1 NAD(P)H-binding adh_short PF00106.25 EDO15092.1 - 9.7e-05 21.9 0.1 0.00036 20.1 0.0 1.9 2 0 0 2 2 2 1 short chain dehydrogenase NmrA PF05368.13 EDO15092.1 - 0.00055 19.6 0.3 0.12 11.9 0.0 2.3 2 0 0 2 2 2 2 NmrA-like family KR PF08659.10 EDO15092.1 - 0.00067 19.6 0.0 0.0012 18.8 0.0 1.3 1 0 0 1 1 1 1 KR domain DUF2963 PF11178.8 EDO15092.1 - 0.065 12.9 0.4 19 5.1 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2963) PilN_bio_d PF18222.1 EDO15092.1 - 0.095 13.1 0.0 0.43 11.0 0.0 2.1 2 0 0 2 2 2 0 PilN biogenesis protein dimerization domain Thiolase_N PF00108.23 EDO15094.1 - 2.6e-79 266.3 0.0 3.6e-79 265.8 0.0 1.2 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 EDO15094.1 - 4.1e-48 162.1 0.6 8.1e-48 161.1 0.6 1.5 1 0 0 1 1 1 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 EDO15094.1 - 0.00024 20.8 0.3 0.0007 19.3 0.0 1.8 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Trigger_C PF05698.14 EDO15094.1 - 0.092 12.8 0.0 0.15 12.1 0.0 1.3 1 0 0 1 1 1 0 Bacterial trigger factor protein (TF) C-terminus DUF1885 PF08968.10 EDO15095.1 - 0.051 13.7 0.4 0.91 9.6 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1885) Glu-tRNAGln PF02686.15 EDO15095.1 - 0.13 12.6 0.1 0.49 10.7 0.1 2.0 1 0 0 1 1 1 0 Glu-tRNAGln amidotransferase C subunit DUF2040 PF09745.9 EDO15096.1 - 2.8e-07 30.6 13.1 6.9e-07 29.4 13.2 1.7 1 1 0 1 1 1 1 Coiled-coil domain-containing protein 55 (DUF2040) vATP-synt_E PF01991.18 EDO15097.1 - 2.4e-53 180.5 22.4 2.7e-53 180.3 22.4 1.0 1 0 0 1 1 1 1 ATP synthase (E/31 kDa) subunit Phlebovirus_NSM PF07246.11 EDO15097.1 - 0.0049 16.3 13.1 0.0079 15.6 13.1 1.3 1 0 0 1 1 1 1 Phlebovirus nonstructural protein NS-M CorA PF01544.18 EDO15098.1 - 8.1e-07 28.6 2.5 1.3e-06 28.0 2.5 1.3 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein SKIP_SNW PF02731.15 EDO15100.1 - 7.9e-50 168.6 11.3 7.9e-50 168.6 11.3 2.1 3 0 0 3 3 3 1 SKIP/SNW domain RNase_P_Rpp14 PF01900.19 EDO15101.1 - 2e-34 117.9 0.0 2.5e-34 117.6 0.0 1.1 1 0 0 1 1 1 1 Rpp14/Pop5 family tRNA-synt_2c PF01411.19 EDO15102.1 - 1.2e-215 717.2 0.4 1.2e-215 717.2 0.4 1.7 2 0 0 2 2 2 1 tRNA synthetases class II (A) tRNA_SAD PF07973.14 EDO15102.1 - 5.8e-17 61.5 0.2 1.9e-16 59.9 0.2 2.0 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain DHHA1 PF02272.19 EDO15102.1 - 4.8e-13 49.7 1.2 1.4e-12 48.2 1.2 1.8 1 0 0 1 1 1 1 DHHA1 domain DUF3800 PF12686.7 EDO15102.1 - 1.3 9.7 4.6 16 6.2 2.8 3.2 2 1 0 2 2 2 0 Protein of unknown function (DUF3800) Fungal_trans PF04082.18 EDO15103.1 - 1.2e-36 126.2 3.6 1.2e-36 126.2 3.6 1.8 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDO15103.1 - 7.4e-07 29.2 9.3 1.4e-06 28.3 9.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SWIRM PF04433.17 EDO15104.1 - 3.1e-10 40.2 0.0 6.4e-10 39.2 0.0 1.5 1 0 0 1 1 1 1 SWIRM domain TIM PF00121.18 EDO15105.1 - 6.1e-89 297.6 0.4 6.9e-89 297.4 0.4 1.0 1 0 0 1 1 1 1 Triosephosphate isomerase SNF2_N PF00176.23 EDO15107.1 - 4e-42 144.2 0.0 6.9e-42 143.4 0.0 1.4 1 1 0 1 1 1 1 SNF2 family N-terminal domain ResIII PF04851.15 EDO15107.1 - 1.1e-14 54.8 0.1 2.6e-14 53.6 0.0 1.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EDO15107.1 - 2.9e-06 27.2 0.0 7e-06 25.9 0.0 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase DUF2439 PF10382.9 EDO15107.1 - 0.00011 22.4 1.0 0.00031 21.0 1.0 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF2439) Helicase_C PF00271.31 EDO15108.1 - 7.3e-16 58.5 0.0 1.8e-15 57.2 0.0 1.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HDA2-3 PF11496.8 EDO15108.1 - 1.3e-09 37.6 2.9 1.4e-08 34.2 1.6 2.3 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 AAA_12 PF13087.6 EDO15108.1 - 0.071 12.7 0.1 0.071 12.7 0.1 1.7 2 1 0 2 2 2 0 AAA domain URO-D PF01208.17 EDO15109.1 - 4.8e-129 430.4 0.0 5.4e-129 430.3 0.0 1.0 1 0 0 1 1 1 1 Uroporphyrinogen decarboxylase (URO-D) DUF4451 PF14616.6 EDO15110.1 - 0.00019 21.6 4.8 0.00019 21.6 4.8 3.2 2 1 1 3 3 3 1 Domain of unknown function (DUF4451) DUF1027 PF06265.11 EDO15110.1 - 0.64 10.1 0.0 0.64 10.1 0.0 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF1027) Sugar_tr PF00083.24 EDO15111.1 - 1.9e-61 208.3 6.9 2.6e-61 207.9 6.9 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDO15111.1 - 1.6e-07 30.6 11.3 1.1e-06 27.9 5.7 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Swm2 PF17083.5 EDO15112.1 - 2e-49 166.9 0.1 2.3e-49 166.7 0.1 1.0 1 0 0 1 1 1 1 Nucleolar protein Swm2 Frag1 PF10277.9 EDO15113.1 - 1.4e-27 96.7 16.6 1.4e-27 96.7 16.6 3.6 2 2 0 2 2 2 1 Frag1/DRAM/Sfk1 family Exo_endo_phos PF03372.23 EDO15113.1 - 0.043 13.3 0.0 0.073 12.6 0.0 1.3 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family COX6B PF02297.17 EDO15114.1 - 1.1e-20 73.7 4.7 1.3e-20 73.4 4.7 1.1 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb CX9C PF16860.5 EDO15114.1 - 0.03 14.3 1.4 0.052 13.6 1.4 1.4 1 0 0 1 1 1 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, APOBEC_C PF05240.14 EDO15114.1 - 0.067 13.1 0.3 0.086 12.8 0.3 1.3 1 0 0 1 1 1 0 APOBEC-like C-terminal domain RIC1 PF07064.13 EDO15115.1 - 3e-22 79.3 2.0 5.6e-22 78.4 2.0 1.4 1 0 0 1 1 1 1 RIC1 GATA PF00320.27 EDO15116.1 - 4.9e-15 54.8 4.7 9.2e-15 54.0 4.7 1.5 1 0 0 1 1 1 1 GATA zinc finger TPP_enzyme_N PF02776.18 EDO15117.1 - 3.9e-23 81.9 0.0 4.6e-23 81.7 0.0 1.1 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain Ribosomal_60s PF00428.19 EDO15118.1 - 4.2e-22 78.5 6.1 5e-22 78.3 6.1 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein Herpes_TK_C PF08465.10 EDO15118.1 - 0.041 13.6 0.0 0.064 13.0 0.0 1.3 1 0 0 1 1 1 0 Thymidine kinase from Herpesvirus C-terminal Ribosomal_S9 PF00380.19 EDO15119.1 - 3e-32 111.7 0.2 3.4e-32 111.5 0.2 1.0 1 0 0 1 1 1 1 Ribosomal protein S9/S16 Rad17 PF03215.15 EDO15120.1 - 1.6e-32 113.0 0.0 4.1e-32 111.6 0.0 1.7 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_16 PF13191.6 EDO15120.1 - 0.00034 21.0 0.0 0.00089 19.7 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA PF00004.29 EDO15120.1 - 0.0011 19.4 0.0 0.0032 17.9 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DUF815 PF05673.13 EDO15120.1 - 0.0078 15.4 0.0 0.019 14.1 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_5 PF07728.14 EDO15120.1 - 0.034 14.2 0.0 0.23 11.5 0.0 2.3 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 EDO15120.1 - 0.048 13.2 0.2 0.14 11.7 0.1 1.8 2 0 0 2 2 2 0 P-loop containing dynein motor region RsgA_GTPase PF03193.16 EDO15120.1 - 0.059 13.3 0.3 0.32 10.9 0.1 2.3 2 0 0 2 2 2 0 RsgA GTPase ABC_tran PF00005.27 EDO15120.1 - 0.077 13.5 0.2 0.33 11.5 0.0 2.2 2 0 0 2 2 2 0 ABC transporter AAA_22 PF13401.6 EDO15120.1 - 0.1 12.9 0.0 0.27 11.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain PRP1_N PF06424.12 EDO15120.1 - 8.5 6.8 13.3 34 4.8 12.8 2.2 1 1 0 1 1 1 0 PRP1 splicing factor, N-terminal Glutaredoxin PF00462.24 EDO15121.1 - 2.5e-20 72.5 0.6 1.2e-17 63.8 0.0 2.7 3 0 0 3 3 3 2 Glutaredoxin Thioredoxin PF00085.20 EDO15121.1 - 3.1e-16 59.2 0.0 5.8e-16 58.4 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 EDO15121.1 - 1.3e-08 35.0 0.1 4.1e-06 27.0 0.0 2.7 1 1 1 2 2 2 2 Thioredoxin-like AhpC-TSA PF00578.21 EDO15121.1 - 1.6e-07 31.3 0.0 2.7e-07 30.6 0.0 1.4 1 0 0 1 1 1 1 AhpC/TSA family Thioredoxin_2 PF13098.6 EDO15121.1 - 3.3e-05 24.3 0.1 0.0012 19.3 0.0 2.8 2 2 1 3 3 3 1 Thioredoxin-like domain Redoxin PF08534.10 EDO15121.1 - 8.5e-05 22.3 0.1 0.00018 21.2 0.1 1.6 1 1 0 1 1 1 1 Redoxin OST3_OST6 PF04756.13 EDO15121.1 - 0.00092 18.6 0.0 0.0011 18.4 0.0 1.2 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_7 PF13899.6 EDO15121.1 - 0.0078 16.4 0.0 0.026 14.7 0.1 1.8 2 0 0 2 2 2 1 Thioredoxin-like Ribosomal_60s PF00428.19 EDO15121.1 - 0.022 15.4 2.7 0.053 14.1 2.7 1.6 1 0 0 1 1 1 0 60s Acidic ribosomal protein TraF PF13728.6 EDO15121.1 - 0.029 14.2 0.0 0.18 11.6 0.0 2.0 2 0 0 2 2 2 0 F plasmid transfer operon protein AAA_12 PF13087.6 EDO15122.1 - 5.2e-62 209.0 4.0 1.1e-61 208.0 0.0 2.7 2 1 0 2 2 2 1 AAA domain AAA_11 PF13086.6 EDO15122.1 - 5.9e-35 121.3 4.1 1.5e-19 70.8 0.3 5.2 3 2 1 4 4 3 2 AAA domain AAA_19 PF13245.6 EDO15122.1 - 6.8e-12 45.9 0.0 2e-11 44.4 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EDO15122.1 - 1.1e-10 41.6 0.0 1.7e-09 37.7 0.0 2.2 1 1 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 EDO15122.1 - 1.3e-06 28.4 3.0 0.096 12.4 0.0 4.1 5 0 0 5 5 5 2 Viral (Superfamily 1) RNA helicase ResIII PF04851.15 EDO15122.1 - 2.2e-05 24.5 0.0 2.2e-05 24.5 0.0 4.1 2 2 1 3 3 2 1 Type III restriction enzyme, res subunit AAA PF00004.29 EDO15122.1 - 0.0018 18.7 0.0 0.027 14.9 0.0 2.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) PhoH PF02562.16 EDO15122.1 - 0.0048 16.4 0.1 0.024 14.1 0.1 2.1 1 1 0 1 1 1 1 PhoH-like protein DEAD PF00270.29 EDO15122.1 - 0.0074 16.1 0.2 0.04 13.7 0.2 2.3 1 1 0 1 1 1 1 DEAD/DEAH box helicase RsgA_GTPase PF03193.16 EDO15122.1 - 0.013 15.4 0.0 0.039 13.8 0.0 1.8 1 0 0 1 1 1 0 RsgA GTPase UvrD_C_2 PF13538.6 EDO15122.1 - 0.033 14.0 0.0 0.071 12.9 0.0 1.6 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain AAA_7 PF12775.7 EDO15122.1 - 0.044 13.3 0.0 0.1 12.1 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_16 PF13191.6 EDO15122.1 - 0.06 13.7 0.0 0.15 12.5 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain DUF4428 PF14471.6 EDO15122.1 - 2.2 8.2 5.8 4.8 7.2 1.6 3.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4428) RVT_2 PF07727.14 EDO15123.1 - 1.8e-35 122.8 1.9 5.7e-35 121.1 1.9 1.8 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Enkurin PF13864.6 EDO15123.1 - 0.037 14.4 0.8 0.037 14.4 0.8 3.6 4 0 0 4 4 4 0 Calmodulin-binding N2227 PF07942.12 EDO15126.1 - 1e-59 202.0 0.1 1e-59 202.0 0.1 1.5 2 0 0 2 2 2 1 N2227-like protein Sec7_N PF12783.7 EDO15126.1 - 0.077 12.9 0.7 1.4 8.8 0.0 2.4 2 1 0 2 2 2 0 Guanine nucleotide exchange factor in Golgi transport N-terminal RRT14 PF17075.5 EDO15126.1 - 0.26 11.4 3.9 0.52 10.4 3.9 1.4 1 0 0 1 1 1 0 Regular of rDNA transcription protein 14 MFS_1 PF07690.16 EDO15127.1 - 2e-23 82.9 37.7 2e-23 82.9 37.7 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily BRO1 PF03097.18 EDO15128.1 - 2.4e-95 319.6 6.2 2.4e-95 319.6 6.2 1.6 2 0 0 2 2 2 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.6 EDO15128.1 - 2.3e-24 86.2 6.8 2.3e-24 86.2 6.8 1.9 2 0 0 2 2 2 1 ALIX V-shaped domain binding to HIV SLATT_6 PF18169.1 EDO15128.1 - 0.0043 16.7 2.2 0.013 15.1 2.2 1.8 1 0 0 1 1 1 1 SMODS and SLOG-associating 2TM effector domain 6 Lipase_chap PF03280.14 EDO15128.1 - 0.011 15.7 0.4 0.029 14.3 0.1 1.8 2 0 0 2 2 2 0 Proteobacterial lipase chaperone protein Fib_alpha PF08702.10 EDO15128.1 - 0.095 12.9 12.0 0.37 11.0 3.0 3.4 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family Myb_DNA-binding PF00249.31 EDO15130.1 - 4.4e-21 74.8 4.6 2.6e-10 40.3 0.5 3.1 3 0 0 3 3 3 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EDO15130.1 - 1.8e-16 60.2 0.7 8.4e-10 38.8 0.6 3.0 1 1 1 2 2 2 2 Myb-like DNA-binding domain Rap1_C PF11626.8 EDO15130.1 - 0.00016 21.7 0.1 0.0081 16.2 0.0 2.7 2 1 0 2 2 2 1 TRF2-interacting telomeric protein/Rap1 - C terminal domain MLTR_LBD PF17765.1 EDO15130.1 - 0.1 12.7 0.8 0.19 11.8 0.8 1.3 1 0 0 1 1 1 0 MmyB-like transcription regulator ligand binding domain PET PF06297.14 EDO15130.1 - 0.16 12.3 3.9 2.6 8.4 0.9 2.8 2 0 0 2 2 2 0 PET Domain CAF20 PF17052.5 EDO15131.1 - 6.5e-53 179.1 5.5 7.4e-53 179.0 5.5 1.0 1 0 0 1 1 1 1 Cap associated factor Pkinase PF00069.25 EDO15132.1 - 1.1e-40 139.7 2.2 4.2e-20 72.2 0.0 3.3 2 1 1 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 EDO15132.1 - 1.7e-09 37.4 3.4 0.017 14.4 0.5 3.2 3 0 0 3 3 3 3 Protein tyrosine kinase RIO1 PF01163.22 EDO15132.1 - 0.13 11.9 0.4 0.31 10.6 0.4 1.7 1 1 0 1 1 1 0 RIO1 family GMP_synt_C PF00958.22 EDO15133.1 - 2.8e-44 149.1 0.0 5.1e-44 148.2 0.0 1.5 1 0 0 1 1 1 1 GMP synthase C terminal domain GATase PF00117.28 EDO15133.1 - 2.7e-40 138.2 0.0 4.6e-40 137.4 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase class-I NAD_synthase PF02540.17 EDO15133.1 - 7.7e-08 31.7 0.0 1.6e-05 24.2 0.0 2.2 2 0 0 2 2 2 2 NAD synthase Peptidase_C26 PF07722.13 EDO15133.1 - 2.8e-06 27.3 0.1 3.6e-05 23.6 0.1 2.5 1 1 0 1 1 1 1 Peptidase C26 QueC PF06508.13 EDO15133.1 - 0.015 14.8 0.0 0.24 10.9 0.0 2.1 2 0 0 2 2 2 0 Queuosine biosynthesis protein QueC Arginosuc_synth PF00764.19 EDO15133.1 - 0.021 14.2 0.1 0.033 13.5 0.1 1.2 1 0 0 1 1 1 0 Arginosuccinate synthase PAPS_reduct PF01507.19 EDO15133.1 - 0.04 14.0 0.0 0.068 13.2 0.0 1.3 1 0 0 1 1 1 0 Phosphoadenosine phosphosulfate reductase family tRNA_Me_trans PF03054.16 EDO15133.1 - 0.044 12.6 0.0 0.095 11.5 0.0 1.5 2 0 0 2 2 2 0 tRNA methyl transferase ThiI PF02568.14 EDO15133.1 - 0.074 12.6 0.0 0.16 11.6 0.0 1.5 2 0 0 2 2 2 0 Thiamine biosynthesis protein (ThiI) FAM222A PF15258.6 EDO15134.1 - 0.11 11.6 1.7 0.21 10.6 1.7 1.4 1 0 0 1 1 1 0 Protein family of FAM222A GDPD PF03009.17 EDO15135.1 - 0.12 12.1 2.1 0.21 11.3 0.9 1.8 2 0 0 2 2 2 0 Glycerophosphoryl diester phosphodiesterase family MFS_1 PF07690.16 EDO15136.1 - 3.5e-10 39.3 18.0 6.2e-10 38.5 16.9 2.0 1 1 0 1 1 1 1 Major Facilitator Superfamily FSH1 PF03959.13 EDO15137.1 - 1e-66 224.6 0.0 1.3e-66 224.3 0.0 1.1 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_2 PF02230.16 EDO15137.1 - 0.00028 20.7 0.0 0.00082 19.2 0.0 1.9 2 1 0 2 2 2 1 Phospholipase/Carboxylesterase Abhydrolase_1 PF00561.20 EDO15137.1 - 0.0036 17.0 0.0 0.078 12.6 0.0 2.3 2 0 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EDO15137.1 - 0.0068 15.7 0.0 0.017 14.4 0.0 1.6 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Peptidase_S15 PF02129.18 EDO15137.1 - 0.036 13.7 0.0 0.055 13.1 0.0 1.2 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) DLH PF01738.18 EDO15137.1 - 0.19 11.2 0.0 0.36 10.3 0.0 1.4 1 1 0 1 1 1 0 Dienelactone hydrolase family Phosducin PF02114.16 EDO15138.1 - 1.3e-06 27.5 5.8 0.0085 15.1 2.0 2.3 1 1 0 2 2 2 2 Phosducin DUF2815 PF10991.8 EDO15138.1 - 2.2 8.2 5.2 69 3.3 0.9 3.1 2 1 0 3 3 3 0 Protein of unknown function (DUF2815) Mre11_DNA_bind PF04152.14 EDO15139.1 - 2.5e-50 171.1 0.8 2.5e-50 171.1 0.8 2.2 3 0 0 3 3 3 1 Mre11 DNA-binding presumed domain Metallophos PF00149.28 EDO15139.1 - 1.8e-14 54.8 0.5 4.6e-14 53.4 0.5 1.8 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EDO15139.1 - 0.0058 16.8 0.0 0.054 13.7 0.0 2.5 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain KorB PF08535.10 EDO15139.1 - 0.042 13.9 0.1 0.15 12.1 0.1 1.9 1 0 0 1 1 1 0 KorB domain SopE_GEF PF07487.13 EDO15139.1 - 0.092 12.8 0.2 11 6.1 0.1 2.4 2 0 0 2 2 2 0 SopE GEF domain His_Phos_1 PF00300.22 EDO15140.1 - 3.6e-40 137.7 0.0 4e-40 137.6 0.0 1.0 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Rhodanese PF00581.20 EDO15141.1 - 1.3e-13 51.3 0.0 1.6e-13 51.1 0.0 1.1 1 0 0 1 1 1 1 Rhodanese-like domain Thump_like PF18096.1 EDO15141.1 - 0.13 12.2 0.0 0.23 11.4 0.0 1.3 1 0 0 1 1 1 0 THUMP domain-like NOG1_N PF17835.1 EDO15142.1 - 1.2e-49 168.4 0.1 1.2e-49 168.4 0.1 2.4 2 0 0 2 2 2 1 NOG1 N-terminal helical domain NOGCT PF08155.11 EDO15142.1 - 7.6e-27 93.1 1.8 2.6e-26 91.4 1.8 2.0 1 0 0 1 1 1 1 NOGCT (NUC087) domain NOG1 PF06858.14 EDO15142.1 - 1.7e-26 91.7 0.2 5.9e-26 90.0 0.2 2.0 1 0 0 1 1 1 1 Nucleolar GTP-binding protein 1 (NOG1) MMR_HSR1 PF01926.23 EDO15142.1 - 4.3e-16 59.0 0.0 1.1e-15 57.7 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EDO15142.1 - 1.4e-07 31.1 0.0 3.4e-07 29.9 0.0 1.6 1 1 0 1 1 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 EDO15142.1 - 0.018 15.0 0.0 4.9 7.0 0.1 2.6 2 0 0 2 2 2 0 RsgA GTPase AAA_16 PF13191.6 EDO15142.1 - 0.03 14.7 0.0 0.14 12.6 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain Dynamin_N PF00350.23 EDO15142.1 - 0.032 14.3 0.0 6.5 6.8 0.0 2.9 1 1 1 2 2 2 0 Dynamin family Roc PF08477.13 EDO15142.1 - 0.1 12.8 0.0 0.29 11.4 0.0 1.8 1 1 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_23 PF13476.6 EDO15142.1 - 0.65 10.5 0.0 0.65 10.5 0.0 2.9 3 1 0 3 3 3 0 AAA domain Pyr_redox_2 PF07992.14 EDO15143.1 - 3e-62 210.5 1.9 4.4e-62 210.0 1.9 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 EDO15143.1 - 3.9e-31 107.6 0.1 1.2e-29 102.8 0.1 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 EDO15143.1 - 2.9e-22 79.0 6.8 2.6e-20 72.8 0.7 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EDO15143.1 - 3.9e-13 49.3 0.8 4.6e-10 39.2 0.2 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EDO15143.1 - 6.6e-10 38.9 0.1 1.4e-09 37.9 0.0 1.5 2 0 0 2 2 2 1 FAD dependent oxidoreductase AlaDh_PNT_C PF01262.21 EDO15143.1 - 3e-06 26.7 1.5 0.045 13.0 0.1 2.5 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain GIDA PF01134.22 EDO15143.1 - 3.2e-06 26.5 3.0 9.5e-05 21.6 0.7 2.5 2 0 0 2 2 2 1 Glucose inhibited division protein A HI0933_like PF03486.14 EDO15143.1 - 5.1e-06 25.5 8.3 0.0036 16.1 0.7 3.9 3 1 1 4 4 4 2 HI0933-like protein K_oxygenase PF13434.6 EDO15143.1 - 5.2e-06 25.8 0.1 1.2e-05 24.6 0.0 1.6 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 EDO15143.1 - 0.00023 21.3 1.1 0.00023 21.3 1.1 2.0 2 0 0 2 2 1 1 NAD(P)-binding Rossmann-like domain 2-Hacid_dh_C PF02826.19 EDO15143.1 - 0.0014 18.0 0.6 0.89 8.9 0.0 2.5 2 0 0 2 2 2 2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain FAD_binding_2 PF00890.24 EDO15143.1 - 0.0014 17.8 4.1 0.0073 15.4 3.0 2.4 3 0 0 3 3 3 1 FAD binding domain Thi4 PF01946.17 EDO15143.1 - 0.0016 17.7 2.4 0.0019 17.5 0.5 2.1 2 0 0 2 2 2 1 Thi4 family 3HCDH_N PF02737.18 EDO15143.1 - 0.0058 16.5 3.9 0.048 13.5 0.1 2.5 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_7 PF13241.6 EDO15143.1 - 0.013 15.9 0.3 1.3 9.6 0.0 2.6 2 0 0 2 2 2 0 Putative NAD(P)-binding FAD_binding_3 PF01494.19 EDO15143.1 - 0.85 8.8 4.1 4.4 6.5 0.9 2.2 2 0 0 2 2 2 0 FAD binding domain NAD_Gly3P_dh_N PF01210.23 EDO15143.1 - 0.88 9.5 3.1 7.8 6.5 0.1 2.4 2 1 0 2 2 2 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Amino_oxidase PF01593.24 EDO15143.1 - 1.2 8.3 4.3 21 4.3 4.3 2.3 1 1 0 1 1 1 0 Flavin containing amine oxidoreductase UDPG_MGDP_dh_N PF03721.14 EDO15143.1 - 1.7 8.2 5.1 0.24 10.9 0.2 2.1 3 0 0 3 3 3 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain ApbA PF02558.16 EDO15143.1 - 5 6.8 6.1 0.4 10.3 0.1 2.3 3 1 0 3 3 3 0 Ketopantoate reductase PanE/ApbA Ribosomal_S6e PF01092.19 EDO15144.1 - 2.7e-56 188.9 0.2 5.5e-56 187.9 0.2 1.5 1 0 0 1 1 1 1 Ribosomal protein S6e SRF-TF PF00319.18 EDO15145.1 - 2.2e-19 68.6 0.1 4.5e-19 67.7 0.1 1.6 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) AMP-binding PF00501.28 EDO15146.1 - 9.7e-82 274.8 0.0 1.2e-81 274.5 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EDO15146.1 - 1.4e-22 80.5 0.1 3.7e-22 79.1 0.1 1.8 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain ACAS_N PF16177.5 EDO15146.1 - 3.3e-19 68.5 1.0 8.3e-19 67.3 1.0 1.8 1 0 0 1 1 1 1 Acetyl-coenzyme A synthetase N-terminus Mem_trans PF03547.18 EDO15147.1 - 8.4e-33 113.3 3.9 3.3e-32 111.3 3.9 2.0 1 1 0 1 1 1 1 Membrane transport protein TcpE PF12648.7 EDO15147.1 - 0.2 12.2 0.2 0.2 12.2 0.2 4.0 3 2 1 4 4 4 0 TcpE family Stm1_N PF09598.10 EDO15148.1 - 2.9e-06 28.0 5.9 2.9e-06 28.0 5.9 4.0 3 1 1 4 4 4 1 Stm1 GLYCAM-1 PF05242.11 EDO15148.1 - 0.031 14.4 0.5 0.031 14.4 0.5 2.3 2 0 0 2 2 2 0 Glycosylation-dependent cell adhesion molecule 1 (GlyCAM-1) Phospho_p8 PF10195.9 EDO15148.1 - 0.12 12.9 0.8 0.12 12.9 0.8 2.5 3 0 0 3 3 3 0 DNA-binding nuclear phosphoprotein p8 Stb3 PF10330.9 EDO15149.1 - 7.7e-33 112.4 0.1 2.6e-32 110.7 0.0 1.9 1 1 0 1 1 1 1 Putative Sin3 binding protein TFIID_30kDa PF03540.13 EDO15150.1 - 7.3e-26 89.9 0.0 1.3e-25 89.1 0.0 1.4 1 0 0 1 1 1 1 Transcription initiation factor TFIID 23-30kDa subunit TAF4 PF05236.14 EDO15150.1 - 0.00083 19.2 2.2 0.00083 19.2 2.2 2.0 2 0 0 2 2 2 1 Transcription initiation factor TFIID component TAF4 family Band_3_cyto PF07565.13 EDO15150.1 - 0.0059 16.4 2.8 0.0059 16.4 2.8 1.9 1 1 1 2 2 2 1 Band 3 cytoplasmic domain HTH_37 PF13744.6 EDO15150.1 - 0.25 11.3 5.2 0.8 9.7 5.2 1.9 1 0 0 1 1 1 0 Helix-turn-helix domain DUF4834 PF16118.5 EDO15150.1 - 2.3 9.2 14.4 4.5 8.3 3.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) PNISR PF15996.5 EDO15150.1 - 2.6 8.3 14.7 3.5 7.8 4.7 2.1 2 0 0 2 2 2 0 Arginine/serine-rich protein PNISR Sec5 PF15469.6 EDO15151.1 - 1.9e-49 168.1 18.4 1.9e-49 168.1 18.4 2.5 2 0 0 2 2 2 1 Exocyst complex component Sec5 CHD5 PF04420.14 EDO15151.1 - 0.026 14.4 0.7 0.086 12.7 0.7 1.9 1 0 0 1 1 1 0 CHD5-like protein HSBP1 PF06825.12 EDO15151.1 - 0.84 9.5 4.2 6 6.8 0.1 3.8 3 0 0 3 3 3 0 Heat shock factor binding protein 1 COG2 PF06148.11 EDO15151.1 - 1.8 8.7 15.6 0.27 11.3 5.2 3.2 3 0 0 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 Spermine_synth PF01564.17 EDO15152.1 - 8.1e-69 230.8 0.4 1.4e-68 230.0 0.4 1.4 1 0 0 1 1 1 1 Spermine/spermidine synthase domain Spermine_synt_N PF17284.2 EDO15152.1 - 5.9e-24 83.7 0.0 1.1e-23 82.8 0.0 1.5 1 0 0 1 1 1 1 Spermidine synthase tetramerisation domain Pyr_redox_2 PF07992.14 EDO15152.1 - 0.02 14.1 0.0 0.028 13.7 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase CMAS PF02353.20 EDO15152.1 - 0.028 13.7 0.0 0.042 13.2 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_12 PF08242.12 EDO15152.1 - 0.036 14.8 0.0 0.078 13.7 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Kelch_1 PF01344.25 EDO15152.1 - 0.079 12.6 0.2 5.8 6.6 0.1 2.3 2 0 0 2 2 2 0 Kelch motif Methyltransf_3 PF01596.17 EDO15152.1 - 0.11 11.6 0.1 0.17 11.1 0.1 1.3 1 0 0 1 1 1 0 O-methyltransferase Methyltransf_25 PF13649.6 EDO15152.1 - 0.15 12.8 0.0 0.31 11.8 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase domain DUF4477 PF14780.6 EDO15153.1 - 0.34 10.5 6.5 0.93 9.1 0.1 3.0 2 1 0 3 3 3 0 Domain of unknown function (DUF4477) Glyco_hydro81C PF17652.1 EDO15154.1 - 4.4e-151 503.1 1.5 5.8e-151 502.7 1.5 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 81 C-terminal domain Glyco_hydro_81 PF03639.13 EDO15154.1 - 1.2e-95 320.4 7.3 1.2e-95 320.4 7.3 1.6 2 0 0 2 2 2 1 Glycosyl hydrolase family 81 N-terminal domain F1F0-ATPsyn_F PF10791.9 EDO15155.1 - 2e-41 140.3 0.1 2.3e-41 140.1 0.1 1.0 1 0 0 1 1 1 1 Mitochondrial F1-F0 ATP synthase subunit F of fungi WRW PF10206.9 EDO15155.1 - 0.022 15.1 0.0 0.028 14.8 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial F1F0-ATP synthase, subunit f ABC_sub_bind PF04392.12 EDO15155.1 - 0.15 11.3 0.0 0.18 11.0 0.0 1.1 1 0 0 1 1 1 0 ABC transporter substrate binding protein AIRC PF00731.20 EDO15156.1 - 8.4e-62 207.1 1.0 1.4e-61 206.4 1.0 1.4 1 0 0 1 1 1 1 AIR carboxylase ATP-grasp PF02222.22 EDO15156.1 - 7.1e-59 198.2 0.0 1.1e-58 197.6 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain PurK_C PF17769.1 EDO15156.1 - 9e-16 57.3 0.0 1.7e-15 56.5 0.0 1.5 1 0 0 1 1 1 1 Phosphoribosylaminoimidazole carboxylase C-terminal domain CPSase_L_D2 PF02786.17 EDO15156.1 - 3.9e-06 26.5 0.0 9.9e-06 25.2 0.0 1.6 2 0 0 2 2 2 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Dala_Dala_lig_C PF07478.13 EDO15156.1 - 0.0012 18.4 0.0 0.0054 16.3 0.0 1.9 1 1 0 1 1 1 1 D-ala D-ala ligase C-terminus 2-Hacid_dh_C PF02826.19 EDO15156.1 - 0.0027 17.1 0.0 0.0048 16.3 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain F420_oxidored PF03807.17 EDO15156.1 - 0.13 12.8 0.4 0.5 11.0 0.1 2.2 2 1 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent CoA_binding_2 PF13380.6 EDO15156.1 - 0.17 12.4 0.5 17 5.9 0.0 2.9 2 1 1 3 3 3 0 CoA binding domain TPP_enzyme_N PF02776.18 EDO15157.1 - 6.9e-24 84.4 0.0 1e-23 83.8 0.0 1.3 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.22 EDO15157.1 - 1.9e-18 66.5 0.0 3.7e-18 65.6 0.0 1.4 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.21 EDO15157.1 - 7.5e-16 58.3 0.0 1.8e-15 57.0 0.0 1.6 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain SPA PF08616.10 EDO15158.1 - 3.5e-35 120.4 1.7 7.8e-35 119.3 1.7 1.7 1 0 0 1 1 1 1 Stabilization of polarity axis Afi1 PF07792.12 EDO15158.1 - 1.8e-33 115.8 4.3 1.8e-33 115.8 4.3 2.7 3 0 0 3 3 3 1 Docking domain of Afi1 for Arf3 in vesicle trafficking Mito_carr PF00153.27 EDO15159.1 - 1.4e-44 149.9 5.8 4.1e-14 52.3 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Bac_export_2 PF01312.19 EDO15159.1 - 0.0061 15.8 1.5 0.0089 15.3 1.5 1.3 1 0 0 1 1 1 1 FlhB HrpN YscU SpaS Family HMD PF03201.16 EDO15159.1 - 0.033 14.4 0.8 0.42 10.9 0.2 2.8 2 1 1 3 3 3 0 H2-forming N5,N10-methylene-tetrahydromethanopterin dehydrogenase PX PF00787.24 EDO15160.1 - 3.9e-08 33.3 0.2 9.8e-08 32.0 0.2 1.7 1 0 0 1 1 1 1 PX domain Vps5 PF09325.10 EDO15160.1 - 1.7e-05 24.5 10.4 1.7e-05 24.5 10.4 1.5 2 0 0 2 2 2 1 Vps5 C terminal like IZUMO PF15005.6 EDO15160.1 - 0.4 11.2 4.8 2.2 8.8 0.1 3.4 2 1 2 4 4 4 0 Izumo sperm-egg fusion, Ig domain-associated GTP_EFTU PF00009.27 EDO15161.1 - 9.1e-67 224.4 0.2 1.3e-66 223.9 0.2 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 EDO15161.1 - 3e-33 114.2 0.0 1.4e-32 112.0 0.0 2.1 2 0 0 2 2 2 1 Elongation factor G, domain IV EFG_C PF00679.24 EDO15161.1 - 7.4e-22 77.2 0.0 2.7e-21 75.4 0.0 2.0 2 0 0 2 2 2 1 Elongation factor G C-terminus EFG_II PF14492.6 EDO15161.1 - 2.3e-13 50.1 0.0 7.4e-13 48.4 0.0 1.9 1 0 0 1 1 1 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.25 EDO15161.1 - 4.4e-12 46.2 0.0 1.5e-11 44.5 0.0 2.0 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EDO15161.1 - 0.00031 20.8 0.2 0.00061 19.8 0.2 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase ERCC4 PF02732.15 EDO15162.1 - 1.2e-21 77.5 0.1 3e-21 76.3 0.1 1.7 1 0 0 1 1 1 1 ERCC4 domain CbiK PF06180.11 EDO15162.1 - 0.062 12.6 0.2 0.94 8.7 0.1 2.3 2 0 0 2 2 2 0 Cobalt chelatase (CbiK) BAR PF03114.18 EDO15163.1 - 6.7e-65 219.1 6.6 8.5e-65 218.7 6.6 1.1 1 0 0 1 1 1 1 BAR domain SH3_1 PF00018.28 EDO15163.1 - 1.2e-10 40.8 0.0 2.1e-10 40.1 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EDO15163.1 - 2.2e-08 33.8 0.1 3.8e-08 33.1 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EDO15163.1 - 1.7e-05 24.4 0.0 3.4e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain DUF755 PF05501.11 EDO15163.1 - 0.12 12.6 1.1 0.24 11.7 1.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF755) CorA PF01544.18 EDO15163.1 - 1.6 7.9 4.6 17 4.6 2.0 2.1 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein RhoGAP PF00620.27 EDO15164.1 - 7.7e-33 113.5 0.6 1.5e-31 109.3 0.6 2.4 1 1 0 1 1 1 1 RhoGAP domain SSP160 PF06933.11 EDO15164.1 - 1.4 7.0 14.2 3.7 5.6 14.2 1.6 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Iso_dh PF00180.20 EDO15165.1 - 1.1e-103 347.1 0.0 1.4e-103 346.7 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase CoA_binding PF02629.19 EDO15166.1 - 3.6e-24 85.2 2.3 3.6e-24 85.2 2.3 2.0 2 0 0 2 2 2 1 CoA binding domain Ligase_CoA PF00549.19 EDO15166.1 - 3.2e-22 79.0 0.7 5.2e-22 78.3 0.7 1.3 1 0 0 1 1 1 1 CoA-ligase Succ_CoA_lig PF13607.6 EDO15166.1 - 3.8e-07 30.0 0.0 6.6e-07 29.2 0.0 1.4 1 0 0 1 1 1 1 Succinyl-CoA ligase like flavodoxin domain CoA_binding_2 PF13380.6 EDO15166.1 - 1.9e-05 25.1 0.0 4.2e-05 24.0 0.0 1.6 1 0 0 1 1 1 1 CoA binding domain NDC10_II PF16787.5 EDO15168.1 - 1.9e-113 378.7 11.7 1.9e-113 378.7 11.7 1.9 2 0 0 2 2 2 1 Centromere DNA-binding protein complex CBF3 subunit, domain 2 GCR1_C PF12550.8 EDO15168.1 - 4.6e-17 62.1 0.8 4.6e-17 62.1 0.8 2.4 2 0 0 2 2 2 1 Transcriptional activator of glycolytic enzymes Aromatic_hydrox PF11723.8 EDO15168.1 - 0.00063 19.3 0.3 0.0016 18.0 0.3 1.6 1 0 0 1 1 1 1 Homotrimeric ring hydroxylase YolD PF08863.10 EDO15168.1 - 0.28 11.3 14.8 2.2 8.4 0.4 4.5 3 1 1 4 4 4 0 YolD-like protein MFS_1 PF07690.16 EDO15169.1 - 4.1e-35 121.4 40.7 7e-35 120.6 34.4 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF2781 PF10914.8 EDO15169.1 - 0.023 15.1 1.6 0.023 15.1 1.6 3.1 3 2 0 3 3 3 0 Protein of unknown function (DUF2781) DUF1635 PF07795.11 EDO15169.1 - 0.17 11.7 0.1 0.17 11.7 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1635) Pet20 PF08692.10 EDO15170.1 - 3.5e-51 173.3 0.1 4.3e-51 173.0 0.1 1.1 1 0 0 1 1 1 1 Mitochondrial protein Pet20 Band_7 PF01145.25 EDO15171.1 - 1.8e-21 76.9 6.7 4.4e-21 75.7 6.7 1.6 1 1 0 1 1 1 1 SPFH domain / Band 7 family MARVEL PF01284.23 EDO15172.1 - 1.3e-27 96.6 12.4 1.6e-27 96.3 12.4 1.1 1 0 0 1 1 1 1 Membrane-associating domain DUF4956 PF16316.5 EDO15172.1 - 0.011 15.4 0.7 4.2 7.0 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4956) DUF3844 PF12955.7 EDO15172.1 - 0.16 12.1 0.0 0.28 11.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3844) BAR_2 PF10455.9 EDO15173.1 - 5.9e-59 199.6 17.7 1.1e-58 198.7 14.2 2.4 2 1 0 2 2 2 1 Bin/amphiphysin/Rvs domain for vesicular trafficking BAR PF03114.18 EDO15173.1 - 6.5e-06 26.0 6.3 3.5e-05 23.6 1.0 2.4 3 0 0 3 3 3 2 BAR domain ATP-cone PF03477.16 EDO15173.1 - 0.017 15.7 1.4 8.2 7.1 0.0 3.3 3 1 1 4 4 4 0 ATP cone domain DUF1664 PF07889.12 EDO15173.1 - 0.022 14.8 2.2 0.22 11.6 0.2 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Tweety PF04906.13 EDO15173.1 - 0.26 9.9 1.3 0.38 9.4 0.1 1.8 2 0 0 2 2 2 0 Tweety Tape_meas_lam_C PF09718.10 EDO15173.1 - 0.37 11.0 3.6 0.7 10.1 0.1 2.5 2 1 0 2 2 2 0 Lambda phage tail tape-measure protein (Tape_meas_lam_C) DUF4709 PF15821.5 EDO15173.1 - 1.2 9.5 5.3 12 6.2 0.0 3.2 4 0 0 4 4 4 0 Domain of unknown function (DUF4709) BAR_2 PF10455.9 EDO15174.1 - 8.3e-23 80.9 7.0 1.2e-22 80.4 7.0 1.3 1 0 0 1 1 1 1 Bin/amphiphysin/Rvs domain for vesicular trafficking MRP-S23 PF10484.9 EDO15174.1 - 0.032 14.5 3.8 0.037 14.3 3.8 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal protein S23 Pox_Ag35 PF03286.14 EDO15174.1 - 0.035 13.9 9.4 0.036 13.8 9.4 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein POX PF07526.11 EDO15174.1 - 0.17 12.5 4.5 0.23 12.0 4.5 1.2 1 0 0 1 1 1 0 Associated with HOX PPL5 PF18168.1 EDO15174.1 - 2.4 7.4 6.9 2.6 7.3 6.9 1.1 1 0 0 1 1 1 0 Prim-pol family 5 TANGO2 PF05742.12 EDO15175.1 - 2.8e-58 197.9 0.1 3.2e-58 197.7 0.1 1.0 1 0 0 1 1 1 1 Transport and Golgi organisation 2 Pox_A12 PF04651.13 EDO15175.1 - 0.038 14.1 0.0 0.089 12.9 0.0 1.6 1 1 0 1 1 1 0 Poxvirus A12 protein RtxA PF07634.11 EDO15175.1 - 0.047 14.2 0.2 0.14 12.7 0.1 1.9 2 0 0 2 2 2 0 RtxA repeat SelP_N PF04592.14 EDO15176.1 - 0.15 11.4 25.5 0.34 10.3 25.5 1.6 1 0 0 1 1 1 0 Selenoprotein P, N terminal region RTA1 PF04479.13 EDO15177.1 - 1.8e-66 223.7 12.4 2.6e-66 223.2 12.4 1.2 1 0 0 1 1 1 1 RTA1 like protein CBF PF03914.17 EDO15178.1 - 1.2e-33 116.5 1.2 2.3e-33 115.6 0.7 1.7 2 0 0 2 2 2 1 CBF/Mak21 family Transcript_VP30 PF11507.8 EDO15178.1 - 0.029 14.4 0.1 0.093 12.8 0.1 1.9 1 1 0 1 1 1 0 Ebola virus-specific transcription factor VP30 Retrotrans_gag PF03732.17 EDO15179.1 - 7.7e-07 29.3 0.0 1.2e-06 28.7 0.0 1.3 1 0 0 1 1 1 1 Retrotransposon gag protein DUF4939 PF16297.5 EDO15179.1 - 5.9e-06 26.1 0.0 7.9e-06 25.7 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4939) Zds_C PF08632.10 EDO15180.1 - 4.8e-28 96.7 2.8 8.4e-28 95.9 2.8 1.4 1 0 0 1 1 1 1 Activator of mitotic machinery Cdc14 phosphatase activation C-term DUF1892 PF08987.10 EDO15181.1 - 8.7e-53 177.2 6.3 9.9e-53 177.0 6.3 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1892) FA_hydroxylase PF04116.13 EDO15182.1 - 1.3e-15 57.9 15.6 1.3e-15 57.9 15.6 1.7 1 1 1 2 2 2 1 Fatty acid hydroxylase superfamily Anth_synt_I_N PF04715.13 EDO15182.1 - 0.0071 16.6 0.1 0.017 15.4 0.1 1.6 1 0 0 1 1 1 1 Anthranilate synthase component I, N terminal region TMEM189_B_dmain PF10520.9 EDO15182.1 - 2.8 8.0 8.6 5.6e+02 0.5 8.6 3.0 1 1 0 1 1 1 0 B domain of TMEM189, localisation domain Pribosyltran PF00156.27 EDO15183.1 - 9e-18 64.3 0.2 1.3e-17 63.8 0.2 1.2 1 0 0 1 1 1 1 Phosphoribosyl transferase domain PXA PF02194.15 EDO15184.1 - 5.3e-31 108.0 1.9 5.3e-31 108.0 1.9 3.0 3 0 0 3 3 3 1 PXA domain Nexin_C PF08628.12 EDO15184.1 - 2.8e-18 66.5 0.2 7.5e-18 65.1 0.2 1.8 1 0 0 1 1 1 1 Sorting nexin C terminal PX PF00787.24 EDO15184.1 - 1.8e-14 53.7 2.8 1.8e-14 53.7 2.8 2.6 2 0 0 2 2 2 1 PX domain Plant_tran PF04827.14 EDO15184.1 - 0.0046 16.6 1.0 2.2 7.8 0.1 3.3 3 0 0 3 3 3 2 Plant transposon protein G-patch PF01585.23 EDO15185.1 - 0.0054 16.6 1.6 0.046 13.6 1.6 2.6 1 1 0 1 1 1 1 G-patch domain CDC45 PF02724.14 EDO15185.1 - 0.68 8.1 30.5 0.71 8.1 30.5 1.1 1 0 0 1 1 1 0 CDC45-like protein Neur_chan_memb PF02932.16 EDO15185.1 - 3.2 7.8 9.2 3.1 7.8 9.2 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region RRM_1 PF00076.22 EDO15186.1 - 5.3e-41 138.3 1.1 2.7e-17 62.3 0.0 4.3 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EDO15186.1 - 6.2e-32 109.3 3.1 1.2e-25 89.1 0.7 3.3 3 0 0 3 3 3 2 Occluded RNA-recognition motif Lsm_interact PF05391.11 EDO15186.1 - 4e-09 35.6 0.8 1.5e-08 33.8 0.8 2.1 1 0 0 1 1 1 1 Lsm interaction motif RRM_5 PF13893.6 EDO15186.1 - 7.5e-08 32.0 2.9 0.0001 21.9 0.0 3.9 3 1 1 4 4 4 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EDO15186.1 - 1.3e-06 28.3 0.0 0.08 13.0 0.0 2.6 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif RL PF17797.1 EDO15186.1 - 0.00029 20.7 1.6 0.39 10.7 0.0 2.8 3 0 0 3 3 3 2 RL domain PHM7_cyt PF14703.6 EDO15186.1 - 0.00035 20.9 2.5 2.4 8.4 0.0 3.9 3 2 1 4 4 4 2 Cytosolic domain of 10TM putative phosphate transporter SRA PF18491.1 EDO15186.1 - 0.027 14.6 1.1 6.1 7.0 1.1 2.9 1 1 0 1 1 1 0 SET and RING associated domain RRM_3 PF08777.11 EDO15186.1 - 0.058 13.5 3.1 0.69 10.0 0.2 2.9 3 0 0 3 3 3 0 RNA binding motif Pyrophosphatase PF00719.19 EDO15187.1 - 4.8e-54 182.5 0.3 6.2e-54 182.1 0.3 1.1 1 0 0 1 1 1 1 Inorganic pyrophosphatase RSN1_7TM PF02714.15 EDO15188.1 - 9.2e-91 303.9 27.3 2e-90 302.8 27.3 1.6 1 0 0 1 1 1 1 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 EDO15188.1 - 1.5e-42 145.0 2.0 1.5e-42 145.0 2.0 3.0 4 0 0 4 4 4 1 Late exocytosis, associated with Golgi transport PHM7_cyt PF14703.6 EDO15188.1 - 9.9e-28 97.5 0.7 1.6e-27 96.9 0.7 1.3 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter PHM7_ext PF12621.8 EDO15188.1 - 1.9e-26 92.0 4.7 2.4e-26 91.7 0.2 3.0 4 0 0 4 4 4 1 Extracellular tail, of 10TM putative phosphate transporter WHIM1 PF15612.6 EDO15189.1 - 1.4e-05 24.5 0.3 0.00016 21.1 0.0 2.6 2 0 0 2 2 2 1 WSTF, HB1, Itc1p, MBD9 motif 1 Phage_sheath_1C PF17482.2 EDO15189.1 - 0.061 13.3 0.1 0.15 12.0 0.1 1.6 1 0 0 1 1 1 0 Phage tail sheath C-terminal domain NDUF_B5 PF09781.9 EDO15189.1 - 0.69 9.5 10.3 0.75 9.3 0.3 2.5 2 0 0 2 2 2 0 NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit SOBP PF15279.6 EDO15189.1 - 5.5 7.5 10.5 13 6.3 10.5 1.6 1 0 0 1 1 1 0 Sine oculis-binding protein Protocadherin PF08374.11 EDO15189.1 - 8 6.4 9.7 26 4.7 9.7 1.8 1 0 0 1 1 1 0 Protocadherin Pkinase PF00069.25 EDO15190.1 - 2.6e-68 230.2 0.0 4.8e-68 229.4 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO15190.1 - 2.6e-37 128.5 0.0 5.8e-37 127.4 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 EDO15190.1 - 0.00018 20.9 0.0 0.0048 16.3 0.0 2.3 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 EDO15190.1 - 0.0021 16.9 1.1 0.034 12.9 0.0 2.1 2 0 0 2 2 2 1 Fungal protein kinase ABC1 PF03109.16 EDO15190.1 - 0.022 15.0 0.0 0.089 13.0 0.0 2.1 2 0 0 2 2 2 0 ABC1 family DUF4704 PF15787.5 EDO15190.1 - 0.037 13.3 0.0 0.07 12.4 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4704) StbA PF06406.11 EDO15190.1 - 0.065 12.5 0.1 0.092 12.0 0.1 1.2 1 0 0 1 1 1 0 StbA protein Glycogen_syn PF05693.13 EDO15191.1 - 0 1104.1 0.0 0 1103.9 0.0 1.0 1 0 0 1 1 1 1 Glycogen synthase Glycos_transf_1 PF00534.20 EDO15191.1 - 2.8e-09 36.7 0.0 3.7e-06 26.6 0.0 2.3 2 0 0 2 2 2 2 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 EDO15191.1 - 4.5e-07 30.4 0.0 0.0012 19.3 0.0 2.5 2 0 0 2 2 2 2 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 EDO15191.1 - 0.00043 20.3 0.2 0.00091 19.3 0.2 1.5 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.6 EDO15191.1 - 0.0024 18.3 0.0 0.0048 17.4 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_transf_5 PF08323.11 EDO15191.1 - 0.019 14.6 0.1 0.051 13.3 0.1 1.6 1 0 0 1 1 1 0 Starch synthase catalytic domain SH3BGR PF04908.15 EDO15192.1 - 0.0013 18.9 0.2 0.05 13.8 0.0 4.0 2 1 1 3 3 3 1 SH3-binding, glutamic acid-rich protein Glutaredoxin PF00462.24 EDO15192.1 - 0.08 13.2 0.0 0.5 10.6 0.0 2.6 1 0 0 1 1 1 0 Glutaredoxin baeRF_family6 PF18848.1 EDO15193.1 - 0.018 15.4 0.1 0.047 14.1 0.1 1.7 1 0 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 6 IMS PF00817.20 EDO15194.1 - 3.7e-39 134.1 0.0 6.1e-39 133.4 0.0 1.4 1 0 0 1 1 1 1 impB/mucB/samB family zf_UBZ PF18439.1 EDO15194.1 - 6.5e-10 38.4 0.3 1.3e-09 37.5 0.3 1.6 1 0 0 1 1 1 1 Ubiquitin-Binding Zinc Finger IMS_C PF11799.8 EDO15194.1 - 1e-07 32.7 0.0 2e-07 31.7 0.0 1.5 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain IMS_HHH PF11798.8 EDO15194.1 - 0.037 14.3 0.0 0.14 12.5 0.0 2.1 1 1 0 1 1 1 0 IMS family HHH motif zf-met PF12874.7 EDO15194.1 - 0.073 13.5 0.6 0.073 13.5 0.6 2.0 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EDO15194.1 - 0.09 13.1 1.7 0.24 11.7 1.7 1.7 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding Ribosomal_L11 PF00298.19 EDO15195.1 - 2e-15 57.0 0.1 3.4e-15 56.3 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain Ribosomal_L11_N PF03946.14 EDO15195.1 - 2.4e-13 49.7 0.4 7.8e-13 48.1 0.2 1.9 2 0 0 2 2 2 1 Ribosomal protein L11, N-terminal domain AMP-binding PF00501.28 EDO15196.1 - 1.2e-69 234.9 0.0 1.6e-69 234.5 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme EB1 PF03271.17 EDO15197.1 - 3.2e-16 59.3 0.1 7e-16 58.2 0.1 1.6 1 0 0 1 1 1 1 EB1-like C-terminal motif CH PF00307.31 EDO15197.1 - 8e-06 26.0 0.1 1.8e-05 24.9 0.1 1.6 1 0 0 1 1 1 1 Calponin homology (CH) domain zf-C4H2 PF10146.9 EDO15197.1 - 0.00095 19.5 4.3 0.0019 18.6 4.3 1.4 1 0 0 1 1 1 1 Zinc finger-containing protein CH_2 PF06294.11 EDO15197.1 - 0.048 13.8 0.1 0.1 12.7 0.1 1.6 1 0 0 1 1 1 0 CH-like domain in sperm protein Peptidase_M41 PF01434.18 EDO15198.1 - 1.9e-67 226.8 0.0 2.9e-67 226.2 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 EDO15198.1 - 2.9e-43 147.5 0.0 1.3e-42 145.4 0.0 2.1 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EDO15198.1 - 1.4e-10 40.8 0.2 3.7e-10 39.5 0.2 1.7 1 0 0 1 1 1 1 AAA+ lid domain FtsH_ext PF06480.15 EDO15198.1 - 0.0001 22.6 3.2 0.00018 21.8 2.0 2.0 2 0 0 2 2 1 1 FtsH Extracellular AAA_5 PF07728.14 EDO15198.1 - 0.00061 19.8 0.0 0.0025 17.8 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EDO15198.1 - 0.0015 18.8 0.1 0.69 10.2 0.1 2.9 3 0 0 3 3 3 1 AAA domain RuvB_N PF05496.12 EDO15198.1 - 0.0045 16.7 0.0 0.0097 15.7 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain TIP49 PF06068.13 EDO15198.1 - 0.011 15.0 0.0 0.011 15.0 0.0 1.7 2 0 0 2 2 2 0 TIP49 P-loop domain AAA_16 PF13191.6 EDO15198.1 - 0.012 16.0 0.6 0.04 14.3 0.1 2.1 2 1 0 2 2 2 0 AAA ATPase domain AAA_17 PF13207.6 EDO15198.1 - 0.014 15.8 0.3 0.045 14.2 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_2 PF07724.14 EDO15198.1 - 0.03 14.5 1.7 0.11 12.6 0.0 2.7 3 0 0 3 3 3 0 AAA domain (Cdc48 subfamily) IstB_IS21 PF01695.17 EDO15198.1 - 0.037 13.7 0.0 0.1 12.4 0.0 1.6 2 0 0 2 2 2 0 IstB-like ATP binding protein Ldi PF18566.1 EDO15198.1 - 0.11 12.0 0.0 0.18 11.3 0.0 1.2 1 0 0 1 1 1 0 Linalool dehydratase/isomerase HMG_box PF00505.19 EDO15199.1 - 2.2e-12 47.2 4.2 9.7e-12 45.1 4.2 2.0 1 1 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EDO15199.1 - 2.1e-05 25.0 0.2 6.4e-05 23.5 0.2 1.8 1 1 0 1 1 1 1 HMG-box domain YopH_N PF09013.10 EDO15199.1 - 0.043 14.1 0.2 0.084 13.1 0.2 1.4 1 0 0 1 1 1 0 YopH, N-terminal Med22 PF06179.12 EDO15200.1 - 3.2e-24 85.2 2.3 4e-24 84.8 2.3 1.1 1 0 0 1 1 1 1 Surfeit locus protein 5 subunit 22 of Mediator complex TMCO5 PF14992.6 EDO15200.1 - 0.061 12.9 3.1 0.068 12.7 3.1 1.1 1 0 0 1 1 1 0 TMCO5 family MIS13 PF08202.11 EDO15201.1 - 5.7e-65 219.6 17.4 5.7e-65 219.6 17.4 1.4 2 0 0 2 2 2 1 Mis12-Mtw1 protein family Glyco_hydro_18 PF00704.28 EDO15201.1 - 0.0039 17.0 4.2 0.29 10.8 0.6 2.3 2 0 0 2 2 2 2 Glycosyl hydrolases family 18 ANAPC4_WD40 PF12894.7 EDO15203.1 - 3.6e-07 30.4 1.1 0.0046 17.2 0.0 5.2 2 1 2 6 6 6 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EDO15203.1 - 0.00023 21.9 11.2 6 7.9 0.4 6.2 7 1 0 7 7 7 2 WD domain, G-beta repeat PQQ_2 PF13360.6 EDO15203.1 - 0.00049 19.7 0.0 0.0038 16.8 0.0 2.2 1 1 1 2 2 2 2 PQQ-like domain PQQ_3 PF13570.6 EDO15203.1 - 0.0062 17.0 0.2 0.21 12.1 0.0 2.9 3 0 0 3 3 3 1 PQQ-like domain WD40_like PF17005.5 EDO15203.1 - 0.018 14.3 0.1 1.3 8.2 0.0 2.5 2 0 0 2 2 2 0 WD40-like domain PQQ PF01011.21 EDO15203.1 - 0.042 13.8 1.4 0.35 10.9 0.0 3.1 4 0 0 4 4 4 0 PQQ enzyme repeat RRN3 PF05327.11 EDO15203.1 - 0.1 11.1 0.4 0.12 10.9 0.4 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Lum_binding PF00677.17 EDO15204.1 - 1.2e-42 143.8 1.4 5.1e-21 74.5 0.3 2.2 2 0 0 2 2 2 2 Lumazine binding domain Spore_GerAC PF05504.11 EDO15204.1 - 0.011 16.0 2.2 0.014 15.6 1.5 1.6 2 0 0 2 2 2 0 Spore germination B3/ GerAC like, C-terminal DUF1905 PF08922.11 EDO15204.1 - 0.02 15.0 0.2 0.56 10.3 0.0 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF1905) YabP PF07873.11 EDO15204.1 - 0.13 12.1 3.3 1.7 8.5 0.0 2.8 3 0 0 3 3 3 0 YabP family Ribosomal_L2_C PF03947.18 EDO15205.1 - 2.7e-44 150.4 4.1 4.9e-44 149.6 4.1 1.4 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 EDO15205.1 - 1.4e-13 50.6 0.2 3.7e-13 49.2 0.2 1.7 1 0 0 1 1 1 1 Ribosomal Proteins L2, RNA binding domain Peptidase_C48 PF02902.19 EDO15206.1 - 2e-35 122.6 8.2 2e-35 122.6 8.2 2.4 2 0 0 2 2 2 1 Ulp1 protease family, C-terminal catalytic domain RINGv PF12906.7 EDO15207.1 - 3e-16 59.3 6.9 5.3e-16 58.5 6.9 1.4 1 0 0 1 1 1 1 RING-variant domain zf-RING_2 PF13639.6 EDO15207.1 - 0.1 12.9 7.2 0.3 11.5 7.3 1.7 1 1 0 1 1 1 0 Ring finger domain FANCL_C PF11793.8 EDO15207.1 - 0.77 10.0 4.1 1.6 8.9 4.1 1.6 1 0 0 1 1 1 0 FANCL C-terminal domain Not1 PF04054.15 EDO15208.1 - 1.4e-125 419.1 3.0 1.4e-125 419.1 3.0 3.1 3 0 0 3 3 3 1 CCR4-Not complex component, Not1 CNOT1_CAF1_bind PF16415.5 EDO15208.1 - 1.5e-81 273.0 4.1 1.5e-81 273.0 4.1 2.9 3 0 0 3 3 3 1 CCR4-NOT transcription complex subunit 1 CAF1-binding domain CNOT1_TTP_bind PF16417.5 EDO15208.1 - 3.4e-43 147.0 0.6 3.4e-43 147.0 0.6 3.0 3 0 0 3 3 3 1 CCR4-NOT transcription complex subunit 1 TTP binding domain DUF3819 PF12842.7 EDO15208.1 - 8.5e-42 142.5 6.6 8.5e-42 142.5 6.6 2.8 3 1 0 3 3 3 1 Domain of unknown function (DUF3819) CNOT1_HEAT PF16418.5 EDO15208.1 - 5.4e-19 68.7 0.9 5.4e-19 68.7 0.9 3.8 5 0 0 5 5 5 1 CCR4-NOT transcription complex subunit 1 HEAT repeat CNOT1_HEAT_N PF16419.5 EDO15208.1 - 2e-16 60.4 0.1 7.1e-16 58.6 0.1 2.1 1 0 0 1 1 1 1 CCR4-NOT transcription complex subunit 1 HEAT repeat DUF1896 PF08989.10 EDO15208.1 - 0.18 11.9 2.3 4 7.5 0.0 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF1896) DUF3573 PF12097.8 EDO15208.1 - 3.5 6.3 7.7 6.5 5.5 7.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) Swi5 PF07061.11 EDO15208.1 - 9.1 6.4 8.3 52 4.0 5.3 3.1 2 1 0 2 2 2 0 Swi5 CDC50 PF03381.15 EDO15209.1 - 1.9e-91 306.5 0.4 2.2e-91 306.2 0.4 1.1 1 0 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family Flocculin PF00624.18 EDO15210.1 - 2.2e-94 309.5 490.6 7.5e-11 42.1 9.1 124.9 71 5 55 127 127 127 25 Flocculin repeat CBP_CCPA PF17040.5 EDO15210.1 - 0.95 10.1 11.7 4.4e+02 1.5 3.0 10.6 1 1 1 2 2 2 0 Cellulose-complementing protein A Helicase_C PF00271.31 EDO15212.1 - 2.3e-17 63.4 0.5 7.8e-17 61.6 0.5 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 EDO15212.1 - 2.2e-07 30.8 0.0 1.7e-06 27.9 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.15 EDO15212.1 - 0.0004 20.4 2.1 0.0019 18.2 0.0 2.8 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit Terminase_6 PF03237.15 EDO15212.1 - 0.025 14.2 0.2 0.057 13.1 0.0 1.7 2 0 0 2 2 2 0 Terminase-like family EamA PF00892.20 EDO15213.1 - 4.1e-07 30.3 34.4 0.00033 20.9 12.6 2.1 2 0 0 2 2 2 2 EamA-like transporter family Nse5 PF08691.10 EDO15214.1 - 8.7e-85 285.3 35.0 1.1e-84 285.0 35.0 1.0 1 0 0 1 1 1 1 DNA repair proteins Nse5 and Nse6 DUF2119 PF09892.9 EDO15214.1 - 0.031 13.7 0.5 0.24 10.8 0.8 2.2 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2119) Ribosomal_L39 PF00832.20 EDO15215.1 - 0.75 9.5 4.7 2.1 8.1 1.5 2.7 2 0 0 2 2 2 0 Ribosomal L39 protein NIF3 PF01784.18 EDO15216.1 - 1.1e-66 224.9 0.1 1.4e-66 224.6 0.1 1.0 1 0 0 1 1 1 1 NIF3 (NGG1p interacting factor 3) BolA PF01722.18 EDO15217.1 - 3.8e-18 65.5 0.0 4.5e-18 65.3 0.0 1.1 1 0 0 1 1 1 1 BolA-like protein Kinesin PF00225.23 EDO15218.1 - 9.7e-113 376.5 5.0 9.7e-113 376.5 5.0 2.3 2 1 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 EDO15218.1 - 2e-24 86.2 0.9 8.7e-24 84.2 0.1 2.6 2 0 0 2 2 2 1 Microtubule binding IMD PF08397.11 EDO15218.1 - 0.0014 18.1 6.0 0.0029 17.0 6.0 1.5 1 0 0 1 1 1 1 IRSp53/MIM homology domain Cyclin PF08613.11 EDO15219.1 - 0.0011 19.3 0.1 0.0028 18.1 0.1 1.7 1 1 0 1 1 1 1 Cyclin EHN PF06441.12 EDO15219.1 - 0.08 13.3 0.1 0.17 12.2 0.1 1.5 1 0 0 1 1 1 0 Epoxide hydrolase N terminus Ras PF00071.22 EDO15222.1 - 1.4e-61 206.8 0.2 1.7e-61 206.6 0.2 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EDO15222.1 - 3.6e-34 117.5 0.1 6e-34 116.8 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EDO15222.1 - 1.7e-13 50.4 0.0 2.3e-13 50.0 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EDO15222.1 - 1.6e-06 28.2 0.0 2.8e-06 27.4 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EDO15222.1 - 0.00027 20.6 0.1 0.00069 19.2 0.1 1.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain PduV-EutP PF10662.9 EDO15222.1 - 0.00053 19.8 0.0 0.00095 18.9 0.0 1.5 1 0 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation Gtr1_RagA PF04670.12 EDO15222.1 - 0.00065 19.1 0.1 0.00087 18.7 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region KAP_NTPase PF07693.14 EDO15222.1 - 0.0017 17.7 0.0 0.0035 16.6 0.0 1.4 1 1 0 1 1 1 1 KAP family P-loop domain SRPRB PF09439.10 EDO15222.1 - 0.0019 17.7 0.1 0.0071 15.8 0.0 1.8 1 1 1 2 2 2 1 Signal recognition particle receptor beta subunit RsgA_GTPase PF03193.16 EDO15222.1 - 0.0026 17.7 0.2 0.024 14.6 0.0 2.0 2 0 0 2 2 2 1 RsgA GTPase AAA_16 PF13191.6 EDO15222.1 - 0.0035 17.8 0.1 0.0058 17.0 0.1 1.4 1 1 0 1 1 1 1 AAA ATPase domain AAA_24 PF13479.6 EDO15222.1 - 0.033 13.9 0.0 0.059 13.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_21 PF13304.6 EDO15222.1 - 0.036 13.9 0.0 0.041 13.7 0.0 1.2 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 EDO15222.1 - 0.046 14.0 0.1 0.091 13.0 0.1 1.9 1 1 0 1 1 1 0 AAA domain Septin PF00735.18 EDO15222.1 - 0.067 12.5 0.0 0.12 11.6 0.0 1.3 1 0 0 1 1 1 0 Septin ABC_tran PF00005.27 EDO15222.1 - 0.08 13.5 0.8 0.18 12.3 0.8 1.8 1 1 0 1 1 1 0 ABC transporter FeoB_N PF02421.18 EDO15222.1 - 0.081 12.4 0.0 0.14 11.7 0.0 1.3 1 0 0 1 1 1 0 Ferrous iron transport protein B CHZ PF09649.10 EDO15223.1 - 2e-18 65.5 2.0 2e-18 65.5 2.0 2.3 3 0 0 3 3 3 1 Histone chaperone domain CHZ LSM PF01423.22 EDO15224.1 - 5.9e-21 73.9 0.7 1e-20 73.2 0.7 1.4 1 0 0 1 1 1 1 LSM domain Menin PF05053.13 EDO15224.1 - 0.34 9.2 3.4 0.4 9.0 3.4 1.0 1 0 0 1 1 1 0 Menin zf-C2H2 PF00096.26 EDO15225.1 - 6.5e-11 42.1 11.7 1.2e-05 25.5 1.7 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EDO15225.1 - 4.1e-07 30.3 9.6 0.0062 17.3 1.3 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EDO15225.1 - 4.3e-05 23.8 5.7 4.3e-05 23.8 5.7 3.7 4 0 0 4 4 4 1 Zinc-finger double domain zf-C2H2_jaz PF12171.8 EDO15225.1 - 0.0062 16.8 1.3 0.99 9.8 0.2 2.6 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.6 EDO15225.1 - 0.058 13.2 5.4 1 9.2 0.1 2.6 2 0 0 2 2 2 0 C2H2-type zinc-finger domain Clathrin PF00637.20 EDO15226.1 - 3.5e-188 617.0 60.9 7.2e-34 116.7 1.3 8.5 9 0 0 9 9 9 7 Region in Clathrin and VPS Clathrin_H_link PF13838.6 EDO15226.1 - 1.4e-27 95.4 0.7 8.8e-27 92.8 0.4 2.6 2 0 0 2 2 2 1 Clathrin-H-link Clathrin_propel PF01394.20 EDO15226.1 - 1.3e-22 78.9 7.1 7.1e-07 29.2 0.3 5.8 5 0 0 5 5 5 5 Clathrin propeller repeat Clathrin-link PF09268.10 EDO15226.1 - 6.5e-06 25.4 3.8 8.2e-06 25.1 0.2 3.0 3 0 0 3 3 3 1 Clathrin, heavy-chain linker DUF3848 PF12959.7 EDO15226.1 - 0.0047 17.0 1.1 0.0047 17.0 1.1 4.1 4 0 0 4 4 4 1 Protein of unknown function (DUF3848) RVT_2 PF07727.14 EDO15227.1 - 1.5e-39 136.1 0.5 2.8e-39 135.2 0.5 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RNase_H PF00075.24 EDO15227.1 - 0.032 14.4 0.0 0.067 13.4 0.0 1.5 1 0 0 1 1 1 0 RNase H Helicase_C PF00271.31 EDO15228.1 - 1.4e-10 41.5 0.1 2e-10 41.0 0.1 1.2 1 0 0 1 1 1 1 Helicase conserved C-terminal domain CLASP_N PF12348.8 EDO15229.1 - 0.0012 18.4 0.2 0.18 11.3 0.0 3.0 1 1 0 2 2 2 1 CLASP N terminal Cnd1 PF12717.7 EDO15229.1 - 0.0016 18.5 0.5 1.4 8.9 0.0 2.7 1 1 1 2 2 2 2 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 EDO15229.1 - 0.012 16.2 0.0 0.31 11.6 0.0 2.9 1 1 2 3 3 3 0 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.6 EDO15229.1 - 0.03 14.8 0.4 1.5e+02 3.0 0.0 4.5 4 1 0 4 4 4 0 HEAT-like repeat HEAT PF02985.22 EDO15229.1 - 0.055 13.7 0.0 6.6 7.3 0.0 3.8 4 0 0 4 4 4 0 HEAT repeat DUF2065 PF09838.9 EDO15229.1 - 0.19 11.8 0.0 1.8 8.7 0.0 2.4 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2065) RRM_1 PF00076.22 EDO15230.1 - 4.6e-18 64.8 0.0 1e-17 63.7 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RL PF17797.1 EDO15230.1 - 0.073 13.0 0.2 0.4 10.6 0.2 2.2 2 1 0 2 2 2 0 RL domain Syja_N PF02383.18 EDO15231.1 - 8.7e-75 252.0 0.3 1.4e-74 251.3 0.3 1.3 1 0 0 1 1 1 1 SacI homology domain Exo_endo_phos PF03372.23 EDO15231.1 - 1.2e-14 54.4 0.0 2.2e-14 53.6 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family SNARE PF05739.19 EDO15232.1 - 2e-11 43.7 5.4 3.8e-11 42.8 5.4 1.5 1 0 0 1 1 1 1 SNARE domain Synaptobrevin PF00957.21 EDO15232.1 - 3.5e-05 23.5 5.7 3.5e-05 23.5 5.7 1.9 2 0 0 2 2 1 1 Synaptobrevin Syntaxin PF00804.25 EDO15232.1 - 0.0024 17.6 1.1 0.0024 17.6 1.1 3.1 3 0 0 3 3 3 1 Syntaxin Rx_N PF18052.1 EDO15232.1 - 0.0042 17.3 1.0 0.0082 16.4 0.2 1.9 2 0 0 2 2 2 1 Rx N-terminal domain OppC_N PF12911.7 EDO15232.1 - 0.0069 16.3 2.2 0.014 15.4 2.2 1.5 1 0 0 1 1 1 1 N-terminal TM domain of oligopeptide transport permease C DHR10 PF18595.1 EDO15232.1 - 0.018 15.1 2.5 0.018 15.1 2.5 2.4 3 1 0 3 3 3 0 Designed helical repeat protein 10 domain Spidroin_MaSp PF11260.8 EDO15232.1 - 0.022 15.1 1.8 0.054 13.8 1.8 1.7 1 1 0 1 1 1 0 Major ampullate spidroin 1 and 2 DUF2207 PF09972.9 EDO15232.1 - 0.03 13.1 4.9 0.015 14.1 3.0 1.4 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) ETRAMP PF09716.10 EDO15232.1 - 0.032 14.3 3.2 0.16 12.1 3.2 2.3 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) SKA2 PF16740.5 EDO15232.1 - 0.043 13.6 7.8 1.3 8.9 0.8 2.7 2 2 0 2 2 2 0 Spindle and kinetochore-associated protein 2 Prominin PF05478.11 EDO15232.1 - 0.65 7.9 20.2 0.041 11.8 10.1 2.0 1 1 1 2 2 2 0 Prominin DUF4519 PF15012.6 EDO15232.1 - 0.82 9.9 6.4 0.82 9.9 0.3 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4519) DUF16 PF01519.16 EDO15232.1 - 1.3 9.5 19.4 0.57 10.7 10.8 2.6 1 1 0 2 2 2 0 Protein of unknown function DUF16 SOAR PF16533.5 EDO15232.1 - 1.7 8.7 9.0 7.9 6.5 3.2 2.8 3 0 0 3 3 3 0 STIM1 Orai1-activating region RNA_pol_Rpb1_5 PF04998.17 EDO15232.1 - 1.7 8.0 6.8 2.1 7.7 6.8 1.3 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 5 DUF1664 PF07889.12 EDO15232.1 - 3.3 7.7 12.5 0.21 11.7 1.6 3.0 2 2 1 3 3 3 0 Protein of unknown function (DUF1664) Equine_IAV_S2 PF06502.11 EDO15232.1 - 6.1 7.0 7.6 1.7 8.8 0.4 2.7 3 0 0 3 3 2 0 Equine infectious anaemia virus S2 protein Orf78 PF06024.12 EDO15232.1 - 7.4 6.9 13.5 0.1 12.9 3.2 2.7 1 1 1 2 2 2 0 Orf78 (ac78) Aa_trans PF01490.18 EDO15233.1 - 8.8e-101 337.6 30.3 1.1e-100 337.3 30.3 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein YrhC PF14143.6 EDO15233.1 - 0.098 12.8 0.9 0.42 10.7 0.9 2.1 1 0 0 1 1 1 0 YrhC-like protein Peptidase_C37 PF05416.12 EDO15234.1 - 0.11 11.0 0.0 0.12 10.9 0.0 1.2 1 0 0 1 1 1 0 Southampton virus-type processing peptidase FeoB_associated PF12669.7 EDO15234.1 - 0.18 12.2 3.8 0.34 11.4 3.8 1.3 1 0 0 1 1 1 0 FeoB-associated Cys-rich membrane protein Ras PF00071.22 EDO15235.1 - 4.7e-57 192.1 0.3 8.1e-57 191.3 0.3 1.4 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EDO15235.1 - 1.1e-20 74.1 0.0 2.5e-20 72.9 0.0 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EDO15235.1 - 8.9e-08 31.8 0.0 1.4e-07 31.1 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 EDO15235.1 - 3.4e-05 23.8 0.4 0.17 11.7 0.1 3.0 2 1 1 3 3 3 2 RsgA GTPase GTP_EFTU PF00009.27 EDO15235.1 - 5.8e-05 22.7 1.4 0.00017 21.2 0.6 2.3 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EDO15235.1 - 0.00056 20.0 0.0 0.0012 18.9 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase MMR_HSR1_Xtn PF16897.5 EDO15235.1 - 0.021 14.8 0.1 0.071 13.1 0.1 1.9 1 1 0 1 1 1 0 C-terminal region of MMR_HSR1 domain ING PF12998.7 EDO15236.1 - 5e-21 75.2 1.5 7e-21 74.7 0.0 1.9 3 0 0 3 3 3 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.29 EDO15236.1 - 5.2e-05 23.0 6.4 8.8e-05 22.3 6.4 1.4 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 EDO15236.1 - 0.023 14.3 1.2 0.046 13.3 1.2 1.5 1 0 0 1 1 1 0 PHD-finger zf-HC5HC2H PF13771.6 EDO15236.1 - 0.055 13.7 0.2 0.15 12.3 0.2 1.7 1 0 0 1 1 1 0 PHD-like zinc-binding domain IF2_N PF04760.15 EDO15236.1 - 0.12 12.2 0.1 0.32 10.9 0.1 1.7 1 0 0 1 1 1 0 Translation initiation factor IF-2, N-terminal region Menin PF05053.13 EDO15236.1 - 7.4 4.8 16.2 10 4.4 16.2 1.1 1 0 0 1 1 1 0 Menin Glyco_transf_15 PF01793.16 EDO15237.1 - 6.5e-124 413.4 19.4 7.9e-124 413.1 19.4 1.0 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase Glyco_transf_15 PF01793.16 EDO15238.1 - 1.2e-83 281.1 19.1 1.5e-83 280.8 19.1 1.1 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase PP2C PF00481.21 EDO15240.1 - 7.4e-41 140.5 0.0 1.7e-40 139.3 0.0 1.5 2 0 0 2 2 2 1 Protein phosphatase 2C Ras PF00071.22 EDO15242.1 - 2e-59 199.8 0.0 2.4e-59 199.5 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EDO15242.1 - 8.8e-35 119.5 0.0 1.2e-34 119.1 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EDO15242.1 - 4.6e-17 62.0 0.0 5.3e-17 61.8 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EDO15242.1 - 3.1e-05 24.0 0.0 6e-05 23.1 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EDO15242.1 - 3.4e-05 23.3 0.0 4.2e-05 23.0 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EDO15242.1 - 9.1e-05 22.1 0.0 0.00012 21.6 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EDO15242.1 - 0.0012 18.8 0.0 1.1 9.1 0.0 2.1 2 0 0 2 2 2 2 RsgA GTPase AAA_16 PF13191.6 EDO15242.1 - 0.069 13.5 0.1 0.098 13.0 0.1 1.3 1 1 0 1 1 1 0 AAA ATPase domain NST1 PF13945.6 EDO15243.1 - 1.2e-05 25.5 2.5 1.2e-05 25.5 2.5 7.4 6 2 1 7 7 7 2 Salt tolerance down-regulator Ras PF00071.22 EDO15244.1 - 8.6e-50 168.5 0.0 9.8e-50 168.3 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EDO15244.1 - 3.4e-22 78.9 0.0 4.5e-22 78.5 0.0 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EDO15244.1 - 7.6e-08 32.0 0.0 1e-07 31.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family PduV-EutP PF10662.9 EDO15244.1 - 0.0053 16.5 0.0 3 7.6 0.0 2.4 2 1 0 2 2 2 2 Ethanolamine utilisation - propanediol utilisation SRPRB PF09439.10 EDO15244.1 - 0.022 14.2 0.0 0.03 13.8 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_21 PF13304.6 EDO15244.1 - 0.027 14.3 0.0 0.038 13.8 0.0 1.3 1 1 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system EMP24_GP25L PF01105.24 EDO15245.1 - 3.5e-44 150.9 0.1 4.5e-44 150.6 0.1 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Lsr2 PF11774.8 EDO15245.1 - 0.031 14.4 0.2 0.047 13.8 0.2 1.2 1 0 0 1 1 1 0 Lsr2 PIP5K PF01504.18 EDO15246.1 - 3.7e-95 318.3 5.0 3.7e-95 318.3 5.0 2.9 3 1 0 3 3 3 1 Phosphatidylinositol-4-phosphate 5-Kinase Aminotran_5 PF00266.19 EDO15247.1 - 2.1e-11 43.4 0.0 2.4e-10 39.9 0.0 2.2 1 1 0 1 1 1 1 Aminotransferase class-V Acatn PF13000.7 EDO15248.1 - 8.9e-249 826.6 13.5 1e-248 826.4 13.5 1.0 1 0 0 1 1 1 1 Acetyl-coenzyme A transporter 1 Scs3p PF10261.9 EDO15249.1 - 2.6e-65 220.4 4.0 3.4e-65 220.0 4.0 1.2 1 0 0 1 1 1 1 Inositol phospholipid synthesis and fat-storage-inducing TM Med31 PF05669.12 EDO15250.1 - 2.9e-23 81.7 0.3 3.7e-23 81.3 0.3 1.2 1 0 0 1 1 1 1 SOH1 CPSase_L_D2 PF02786.17 EDO15251.1 - 7.4e-84 280.5 0.5 1.4e-83 279.6 0.5 1.5 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain PYC_OADA PF02436.18 EDO15251.1 - 2.2e-68 229.9 0.0 3.9e-68 229.1 0.0 1.5 1 0 0 1 1 1 1 Conserved carboxylase domain Biotin_carb_N PF00289.22 EDO15251.1 - 2.3e-38 131.1 0.0 5.8e-38 129.8 0.0 1.8 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 EDO15251.1 - 1.2e-30 105.7 0.0 3.3e-30 104.4 0.0 1.8 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain HMGL-like PF00682.19 EDO15251.1 - 1.8e-25 90.0 0.1 6.1e-25 88.3 0.1 1.9 2 0 0 2 2 2 1 HMGL-like Biotin_lipoyl PF00364.22 EDO15251.1 - 8.1e-18 64.0 4.0 8.1e-18 64.0 4.0 2.8 3 0 0 3 3 2 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.6 EDO15251.1 - 9.8e-10 38.1 0.5 7.7e-05 22.4 0.2 2.7 1 1 1 2 2 2 2 Biotin-lipoyl like ATP-grasp PF02222.22 EDO15251.1 - 1.1e-06 28.3 0.1 2.4e-06 27.2 0.1 1.5 1 0 0 1 1 1 1 ATP-grasp domain Dala_Dala_lig_C PF07478.13 EDO15251.1 - 1.2e-05 24.9 0.0 2.7e-05 23.8 0.0 1.5 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp_3 PF02655.14 EDO15251.1 - 2.3e-05 24.5 0.1 6.5e-05 23.0 0.1 1.9 1 0 0 1 1 1 1 ATP-grasp domain HlyD_D23 PF16576.5 EDO15251.1 - 4.1e-05 22.9 0.4 0.0019 17.5 0.5 2.6 1 1 1 2 2 2 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion ATPgrasp_ST PF14397.6 EDO15251.1 - 0.0025 17.1 0.0 0.0064 15.8 0.0 1.6 1 0 0 1 1 1 1 Sugar-transfer associated ATP-grasp HlyD_3 PF13437.6 EDO15251.1 - 0.021 15.5 2.4 0.19 12.4 0.6 3.4 3 1 1 4 4 4 0 HlyD family secretion protein ATP-grasp_4 PF13535.6 EDO15251.1 - 0.039 13.5 0.0 0.082 12.5 0.0 1.6 1 0 0 1 1 1 0 ATP-grasp domain RnfC_N PF13375.6 EDO15251.1 - 0.059 13.3 5.2 0.21 11.6 2.7 2.7 2 1 0 2 2 2 0 RnfC Barrel sandwich hybrid domain ATPgrasp_Ter PF15632.6 EDO15251.1 - 0.095 12.5 0.1 0.24 11.1 0.1 1.7 1 0 0 1 1 1 0 ATP-grasp in the biosynthetic pathway with Ter operon DASH_Duo1 PF08651.10 EDO15252.1 - 8.9e-22 76.7 0.6 2.6e-21 75.2 0.2 2.0 2 0 0 2 2 2 1 DASH complex subunit Duo1 BCDHK_Adom3 PF10436.9 EDO15253.1 - 2e-28 99.3 0.6 3.6e-28 98.4 0.6 1.4 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 EDO15253.1 - 3.2e-06 27.6 0.0 0.0053 17.2 0.0 2.6 2 0 0 2 2 2 2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 EDO15253.1 - 0.069 13.0 0.0 0.16 11.8 0.0 1.5 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase UQ_con PF00179.26 EDO15254.1 - 4.3e-51 172.2 0.1 5.1e-51 172.0 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EDO15254.1 - 0.0019 17.9 0.1 0.004 16.8 0.0 1.5 1 1 1 2 2 2 1 Prokaryotic E2 family B RWD PF05773.22 EDO15254.1 - 0.016 15.5 0.1 0.039 14.2 0.1 1.7 1 1 0 1 1 1 0 RWD domain UEV PF05743.13 EDO15254.1 - 0.029 14.2 0.0 0.052 13.4 0.0 1.4 1 0 0 1 1 1 0 UEV domain Cyclin_N PF00134.23 EDO15256.1 - 2.6e-46 156.5 0.4 5.8e-46 155.4 0.4 1.6 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 EDO15256.1 - 4.8e-35 120.2 0.1 1.3e-34 118.8 0.0 1.8 2 0 0 2 2 2 1 Cyclin, C-terminal domain MutS_V PF00488.21 EDO15257.1 - 1.8e-45 155.3 0.1 3.7e-45 154.3 0.1 1.6 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 EDO15257.1 - 2.7e-23 83.2 0.2 6.4e-23 82.0 0.2 1.7 1 0 0 1 1 1 1 MutS domain III DAP3 PF10236.9 EDO15257.1 - 0.046 12.9 0.0 0.27 10.4 0.0 2.0 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 AAA_14 PF13173.6 EDO15257.1 - 0.093 12.8 1.7 0.39 10.8 0.0 2.9 3 0 0 3 3 3 0 AAA domain NACHT PF05729.12 EDO15257.1 - 0.16 11.8 0.7 0.65 9.9 0.1 2.3 2 1 0 2 2 2 0 NACHT domain Sas10 PF09368.10 EDO15258.1 - 3.1e-29 101.3 12.6 3.1e-29 101.3 12.6 2.3 2 0 0 2 2 2 1 Sas10 C-terminal domain Sas10_Utp3 PF04000.15 EDO15258.1 - 2.7e-07 31.1 1.1 2.7e-07 31.1 1.1 2.9 3 0 0 3 3 3 1 Sas10/Utp3/C1D family RNA_pol_Rpc4 PF05132.14 EDO15259.1 - 9.9e-31 107.2 2.3 9.9e-31 107.2 2.3 2.9 4 0 0 4 4 4 1 RNA polymerase III RPC4 BSMAP PF12280.8 EDO15259.1 - 1.4 9.1 4.7 0.24 11.6 0.7 1.8 2 0 0 2 2 2 0 Brain specific membrane anchored protein APG9 PF04109.16 EDO15260.1 - 2.1e-194 647.0 15.5 2.5e-194 646.8 15.5 1.1 1 0 0 1 1 1 1 Autophagy protein Apg9 MFS_1 PF07690.16 EDO15261.1 - 9.2e-26 90.6 37.4 9.2e-26 90.6 37.4 1.8 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EDO15261.1 - 0.09 11.6 34.4 0.018 13.9 6.8 4.0 2 2 1 4 4 4 0 Sugar (and other) transporter Nop14 PF04147.12 EDO15262.1 - 5.1e-176 587.5 72.3 7.4e-94 315.7 21.9 2.1 1 1 1 2 2 2 2 Nop14-like family SURF6 PF04935.12 EDO15263.1 - 5.6e-45 153.6 47.3 5.6e-45 153.6 47.3 3.3 2 1 1 3 3 3 1 Surfeit locus protein 6 RRP14 PF15459.6 EDO15263.1 - 1.4e-12 48.0 1.7 1.4e-12 48.0 1.7 7.5 6 1 1 7 7 7 1 60S ribosome biogenesis protein Rrp14 zf-CHY PF05495.12 EDO15264.1 - 2.5e-11 43.9 24.3 4.6e-11 43.1 23.1 1.8 1 1 1 2 2 2 1 CHY zinc finger DUF2689 PF10894.8 EDO15264.1 - 0.035 13.9 0.3 0.059 13.2 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2689) G-alpha PF00503.20 EDO15265.1 - 2.2e-107 359.3 5.5 2.7e-107 359.0 5.5 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 EDO15265.1 - 5e-13 48.9 0.4 1.8e-09 37.3 0.0 2.7 2 1 0 2 2 2 2 ADP-ribosylation factor family Cyto_heme_lyase PF01265.17 EDO15266.1 - 4.6e-44 151.2 2.4 1.2e-42 146.5 2.4 2.0 1 1 0 1 1 1 1 Cytochrome c/c1 heme lyase zf-Tim10_DDP PF02953.15 EDO15267.1 - 5.8e-20 70.7 2.5 7.2e-20 70.4 2.5 1.1 1 0 0 1 1 1 1 Tim10/DDP family zinc finger Flavoprotein PF02441.19 EDO15268.1 - 2e-53 180.4 0.1 3.4e-53 179.6 0.1 1.4 1 0 0 1 1 1 1 Flavoprotein DNA_pol_phi PF04931.13 EDO15268.1 - 0.046 11.8 44.5 0.12 10.5 44.5 1.7 1 0 0 1 1 1 0 DNA polymerase phi RNA_pol_Rpc4 PF05132.14 EDO15268.1 - 0.88 10.0 3.8 2.9 8.3 3.8 1.9 1 0 0 1 1 1 0 RNA polymerase III RPC4 Zip PF02535.22 EDO15268.1 - 1.9 7.7 4.5 4 6.6 4.5 1.5 1 0 0 1 1 1 0 ZIP Zinc transporter GNAT_acetyltr_2 PF13718.6 EDO15268.1 - 3.2 7.1 4.7 32 3.8 0.0 2.5 2 0 0 2 2 2 0 GNAT acetyltransferase 2 CKAP2_C PF15297.6 EDO15268.1 - 5.1 6.1 13.9 2.1 7.4 10.6 1.9 2 0 0 2 2 2 0 Cytoskeleton-associated protein 2 C-terminus CNDH2_C PF16858.5 EDO15268.1 - 7.1 6.4 17.3 4.6 7.0 15.0 1.9 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term Mid2 PF04478.12 EDO15270.1 - 8e-56 188.0 2.4 8e-56 188.0 2.4 2.2 2 0 0 2 2 2 1 Mid2 like cell wall stress sensor Myc_N PF01056.18 EDO15270.1 - 0.003 17.5 1.3 0.0054 16.7 1.3 1.4 1 0 0 1 1 1 1 Myc amino-terminal region COX14 PF14880.6 EDO15271.1 - 7.9e-26 89.7 0.6 8.8e-26 89.5 0.6 1.0 1 0 0 1 1 1 1 Cytochrome oxidase c assembly DUF4064 PF13273.6 EDO15271.1 - 0.14 12.5 0.0 0.17 12.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4064) Ribosomal_L2_C PF03947.18 EDO15271.1 - 0.15 12.3 0.0 0.16 12.2 0.0 1.0 1 0 0 1 1 1 0 Ribosomal Proteins L2, C-terminal domain Rtf2 PF04641.12 EDO15272.1 - 8.3e-31 107.3 3.5 6.6e-30 104.3 3.5 1.9 1 1 0 1 1 1 1 Rtf2 RING-finger zf-Nse PF11789.8 EDO15272.1 - 0.033 14.0 0.2 0.65 9.9 0.2 2.4 1 1 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Zn-C2H2_12 PF18112.1 EDO15272.1 - 0.23 11.9 0.7 0.56 10.7 0.7 1.6 1 0 0 1 1 1 0 Autophagy receptor zinc finger-C2H2 domain zf-CCCH PF00642.24 EDO15273.1 - 2.3e-09 36.9 13.5 2.6e-05 24.0 0.6 2.8 3 0 0 3 3 3 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Torus PF16131.5 EDO15273.1 - 1.1e-06 29.2 0.3 0.05 14.3 0.0 2.4 2 0 0 2 2 2 2 Torus domain zf-CCCH_4 PF18044.1 EDO15273.1 - 0.0011 18.7 14.9 0.0041 16.9 0.8 3.2 3 0 0 3 3 3 2 CCCH-type zinc finger zf-CCCH_3 PF15663.5 EDO15273.1 - 0.0012 19.1 2.1 0.17 12.1 0.2 2.4 2 0 0 2 2 2 2 Zinc-finger containing family zf_CCCH_4 PF18345.1 EDO15273.1 - 0.0013 18.8 20.6 0.011 15.8 4.1 3.0 3 0 0 3 3 3 2 Zinc finger domain RRM_1 PF00076.22 EDO15273.1 - 0.0013 18.5 0.0 0.002 17.9 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Proteasome PF00227.26 EDO15274.1 - 2.1e-58 196.9 0.0 2.7e-58 196.6 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EDO15274.1 - 1.4e-09 37.5 0.2 4.7e-09 35.8 0.1 1.9 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature Prefoldin PF02996.17 EDO15275.1 - 5.5e-25 87.6 6.1 7.3e-25 87.2 6.1 1.2 1 0 0 1 1 1 1 Prefoldin subunit PHM7_cyt PF14703.6 EDO15275.1 - 0.0048 17.2 5.0 0.0062 16.8 5.0 1.2 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter Asn_synthase PF00733.21 EDO15276.1 - 1.1e-19 71.3 0.2 4.2e-11 43.1 0.0 2.8 1 1 1 2 2 2 2 Asparagine synthase GATase_7 PF13537.6 EDO15276.1 - 1.2e-11 44.6 0.1 7.7e-10 38.8 0.0 2.9 3 1 0 3 3 3 1 Glutamine amidotransferase domain GATase_6 PF13522.6 EDO15276.1 - 1.5e-07 31.7 0.0 7.3e-07 29.5 0.0 2.0 1 1 0 1 1 1 1 Glutamine amidotransferase domain DUF3700 PF12481.8 EDO15276.1 - 0.0032 17.0 0.0 0.0075 15.7 0.0 1.5 1 0 0 1 1 1 1 Aluminium induced protein VPS9 PF02204.18 EDO15277.1 - 1.9e-26 92.3 0.0 4.2e-26 91.2 0.0 1.6 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain DUF5601 PF18151.1 EDO15277.1 - 5.8e-12 45.8 0.4 2.4e-11 43.8 0.4 2.2 1 0 0 1 1 1 1 Domain of unknown function (DUF5601) CUE PF02845.16 EDO15277.1 - 3.6e-10 39.4 0.0 7.5e-10 38.3 0.0 1.6 1 0 0 1 1 1 1 CUE domain DUF3208 PF11482.8 EDO15277.1 - 0.025 14.9 0.1 0.09 13.1 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3208) DUF2935 PF11155.8 EDO15277.1 - 0.033 14.5 0.5 0.24 11.8 0.3 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF2935) TFIID-18kDa PF02269.16 EDO15278.1 - 7e-31 106.1 0.0 1e-30 105.6 0.0 1.2 1 0 0 1 1 1 1 Transcription initiation factor IID, 18kD subunit Histone PF00125.24 EDO15278.1 - 0.016 15.5 0.5 0.15 12.4 0.0 2.6 3 1 0 3 3 3 0 Core histone H2A/H2B/H3/H4 Bromo_TP PF07524.13 EDO15278.1 - 0.037 14.0 0.0 0.11 12.5 0.0 1.7 2 0 0 2 2 2 0 Bromodomain associated MTS PF05175.14 EDO15278.1 - 0.045 13.3 0.0 0.075 12.6 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain Astro_capsid_p PF12226.8 EDO15278.1 - 0.97 8.5 16.4 1.2 8.2 16.4 1.2 1 0 0 1 1 1 0 Turkey astrovirus capsid protein NOA36 PF06524.12 EDO15278.1 - 5.2 6.3 19.3 6.3 6.0 19.3 1.2 1 0 0 1 1 1 0 NOA36 protein Fungal_trans_2 PF11951.8 EDO15279.1 - 5.9e-103 344.6 6.7 8.5e-103 344.1 6.7 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDO15279.1 - 2.2e-09 37.3 7.5 4.6e-09 36.3 7.5 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Ribonuclease_3 PF00636.26 EDO15280.1 - 3.7e-18 66.1 0.0 1.6e-17 64.0 0.0 2.1 1 0 0 1 1 1 1 Ribonuclease III domain dsrm PF00035.26 EDO15280.1 - 1.1e-16 61.2 0.0 9.6e-08 32.6 0.0 2.5 2 0 0 2 2 2 2 Double-stranded RNA binding motif Ribonucleas_3_3 PF14622.6 EDO15280.1 - 1.6e-14 54.2 0.1 4.9e-14 52.6 0.0 1.9 1 1 1 2 2 2 1 Ribonuclease-III-like CaMKII_AD PF08332.10 EDO15280.1 - 0.022 14.9 0.0 0.055 13.6 0.0 1.6 1 0 0 1 1 1 0 Calcium/calmodulin dependent protein kinase II association domain MFS_1 PF07690.16 EDO15281.1 - 4.4e-40 137.7 21.4 6.7e-40 137.1 21.4 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Jagunal PF07086.12 EDO15281.1 - 0.011 15.8 3.7 0.047 13.8 3.2 2.2 2 0 0 2 2 2 0 Jagunal, ER re-organisation during oogenesis DUF4519 PF15012.6 EDO15281.1 - 0.065 13.4 0.0 0.18 12.0 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4519) OPT PF03169.15 EDO15282.1 - 5.5e-159 530.7 45.7 6.3e-159 530.5 45.7 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein Phage_holin_5_2 PF16079.5 EDO15282.1 - 0.81 10.1 3.6 0.88 10.0 0.1 2.9 3 0 0 3 3 3 0 Phage holin family Hol44, in holin superfamily V rve PF00665.26 EDO15283.1 - 1.9e-15 57.1 0.0 3.3e-15 56.3 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 EDO15283.1 - 0.0022 17.7 0.0 0.0043 16.8 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain Phage-tail_1 PF09097.10 EDO15283.1 - 0.073 12.9 0.0 0.13 12.1 0.0 1.3 1 0 0 1 1 1 0 Baseplate structural protein, domain 1 gag_pre-integrs PF13976.6 EDO15284.1 - 1.3e-08 34.5 0.0 2.2e-08 33.8 0.0 1.4 1 0 0 1 1 1 1 GAG-pre-integrase domain HATPase_c_3 PF13589.6 EDO15287.1 - 0.085 12.7 0.6 0.37 10.6 0.1 2.3 2 1 0 2 2 2 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Aldo_ket_red PF00248.21 EDO15289.1 - 2.7e-63 213.9 0.0 3e-63 213.7 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family DUF3533 PF12051.8 EDO15290.1 - 6.2e-142 473.0 19.8 7.5e-142 472.7 19.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3533) DUF3810 PF12725.7 EDO15290.1 - 0.058 12.7 0.1 0.058 12.7 0.1 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF3810) PDR_CDR PF06422.12 EDO15290.1 - 0.13 12.2 0.1 0.13 12.2 0.1 3.1 4 0 0 4 4 4 0 CDR ABC transporter Flavodoxin_2 PF02525.17 EDO15291.1 - 1.7e-51 174.8 0.0 2e-51 174.5 0.0 1.1 1 0 0 1 1 1 1 Flavodoxin-like fold FMN_red PF03358.15 EDO15291.1 - 9.7e-13 48.1 0.0 2.6e-12 46.8 0.0 1.7 2 1 0 2 2 2 1 NADPH-dependent FMN reductase Zn_clus PF00172.18 EDO15294.1 - 8.2e-08 32.3 12.3 1.7e-07 31.3 12.3 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain RrnaAD PF00398.20 EDO15295.1 - 1.4e-74 250.5 0.0 1.7e-74 250.3 0.0 1.0 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_25 PF13649.6 EDO15295.1 - 4e-07 30.7 0.0 8.7e-07 29.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EDO15295.1 - 3.8e-05 24.3 0.0 9.9e-05 22.9 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 EDO15295.1 - 0.00013 21.8 0.0 0.00023 21.0 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) PRMT5 PF05185.16 EDO15295.1 - 0.0012 18.8 0.2 0.41 10.5 0.0 2.3 2 0 0 2 2 2 2 PRMT5 arginine-N-methyltransferase CMAS PF02353.20 EDO15295.1 - 0.0012 18.2 0.0 0.003 16.9 0.0 1.5 2 0 0 2 2 2 1 Mycolic acid cyclopropane synthetase Met_10 PF02475.16 EDO15295.1 - 0.0021 17.8 0.0 0.004 16.9 0.0 1.4 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_23 PF13489.6 EDO15295.1 - 0.011 15.6 0.0 0.016 15.0 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.12 EDO15295.1 - 0.012 16.4 0.0 0.029 15.1 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain MTS PF05175.14 EDO15295.1 - 0.015 14.8 0.0 0.026 14.1 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain Ubie_methyltran PF01209.18 EDO15295.1 - 0.019 14.3 0.1 0.12 11.7 0.0 1.9 2 0 0 2 2 2 0 ubiE/COQ5 methyltransferase family Methyltransf_28 PF02636.17 EDO15295.1 - 0.046 13.4 0.0 0.082 12.5 0.0 1.5 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_2 PF00891.18 EDO15295.1 - 0.064 12.5 0.0 0.11 11.8 0.0 1.3 1 0 0 1 1 1 0 O-methyltransferase domain AAA_lid_4 PF17864.1 EDO15295.1 - 0.1 12.4 0.0 0.26 11.1 0.0 1.6 1 0 0 1 1 1 0 RuvB AAA lid domain UPF0158 PF03682.13 EDO15295.1 - 0.13 12.3 0.1 0.23 11.4 0.1 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0158) PI-PLC-X PF00388.19 EDO15296.1 - 9.5e-48 161.5 0.0 2.1e-47 160.3 0.0 1.6 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 EDO15296.1 - 1.5e-36 125.2 0.4 6.9e-36 123.1 0.0 2.4 3 0 0 3 3 3 1 Phosphatidylinositol-specific phospholipase C, Y domain EF-hand_like PF09279.11 EDO15296.1 - 4.7e-07 30.2 0.4 1.8e-06 28.4 0.4 2.0 1 0 0 1 1 1 1 Phosphoinositide-specific phospholipase C, efhand-like EF-hand_1 PF00036.32 EDO15296.1 - 5.4e-05 22.5 0.1 0.0014 18.0 0.0 2.8 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.6 EDO15296.1 - 9.3e-05 22.8 1.1 0.047 14.1 0.1 3.0 2 0 0 2 2 2 2 EF-hand domain pair C2 PF00168.30 EDO15296.1 - 0.0023 18.2 0.0 0.0088 16.3 0.0 2.1 2 0 0 2 2 2 1 C2 domain EF-hand_8 PF13833.6 EDO15296.1 - 0.017 14.9 0.2 1.3 9.0 0.1 2.7 2 0 0 2 2 2 0 EF-hand domain pair EF-hand_5 PF13202.6 EDO15296.1 - 0.024 14.1 0.1 0.062 12.8 0.1 1.8 1 0 0 1 1 1 0 EF hand EF-hand_6 PF13405.6 EDO15296.1 - 0.04 13.8 0.5 0.22 11.6 0.2 2.5 2 0 0 2 2 2 0 EF-hand domain Helicase_C PF00271.31 EDO15297.1 - 3.9e-18 65.8 0.1 3.9e-18 65.8 0.1 2.4 3 0 0 3 3 3 1 Helicase conserved C-terminal domain Spt20 PF12090.8 EDO15300.1 - 2.3e-75 253.2 15.8 2.3e-75 253.2 15.8 4.3 4 1 0 4 4 4 2 Spt20 family SEP PF08059.13 EDO15300.1 - 0.08 13.5 1.6 0.15 12.7 0.0 2.4 2 0 0 2 2 2 0 SEP domain PEX11 PF05648.14 EDO15301.1 - 2.1e-66 223.6 5.5 2.3e-66 223.4 5.5 1.0 1 0 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) Sld5 PF05916.11 EDO15302.1 - 4.8e-20 72.0 0.0 6.3e-20 71.7 0.0 1.2 1 0 0 1 1 1 1 GINS complex protein RRM_1 PF00076.22 EDO15303.1 - 0.00059 19.6 0.7 0.0013 18.5 0.7 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DMRL_synthase PF00885.19 EDO15304.1 - 7e-52 175.0 0.0 8.4e-52 174.7 0.0 1.0 1 0 0 1 1 1 1 6,7-dimethyl-8-ribityllumazine synthase DUF2390 PF09523.10 EDO15304.1 - 0.13 12.6 0.0 0.19 12.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2390) ParBc PF02195.18 EDO15304.1 - 0.17 12.2 0.0 0.28 11.5 0.0 1.3 1 0 0 1 1 1 0 ParB-like nuclease domain Hist_deacetyl PF00850.19 EDO15305.1 - 7.8e-84 281.7 0.2 1.6e-83 280.7 0.0 1.5 2 0 0 2 2 2 1 Histone deacetylase domain Pam16 PF03656.13 EDO15306.1 - 0.014 15.4 0.0 0.019 15.0 0.0 1.3 1 0 0 1 1 1 0 Pam16 DnaJ PF00226.31 EDO15306.1 - 0.048 13.8 0.1 0.091 12.9 0.1 1.5 1 0 0 1 1 1 0 DnaJ domain DUF4307 PF14155.6 EDO15306.1 - 0.12 12.2 0.0 0.17 11.7 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4307) CDP-OH_P_tran_2 PF08009.11 EDO15306.1 - 0.31 11.0 2.7 0.54 10.2 2.7 1.4 1 0 0 1 1 1 0 CDP-alcohol phosphatidyltransferase 2 CDC50 PF03381.15 EDO15308.1 - 1.3e-82 277.5 1.1 1.3e-82 277.5 1.1 1.4 2 0 0 2 2 2 1 LEM3 (ligand-effect modulator 3) family / CDC50 family PBP1_TM PF14812.6 EDO15308.1 - 0.43 11.0 5.3 1 9.8 5.3 1.6 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF3040 PF11239.8 EDO15308.1 - 0.43 10.9 0.8 21 5.5 0.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3040) KRE1 PF17056.5 EDO15309.1 - 1.7e-23 82.1 9.8 1.7e-23 82.1 9.8 4.6 4 1 1 5 5 5 1 Killer toxin-resistance protein 1 Na_Ca_ex PF01699.24 EDO15310.1 - 6.7e-18 65.1 36.5 4.8e-16 59.1 11.0 3.8 4 1 0 4 4 4 2 Sodium/calcium exchanger protein YccF PF03733.13 EDO15310.1 - 1e-13 51.8 8.9 1e-13 51.8 8.9 4.9 5 0 0 5 5 5 1 Inner membrane component domain DUF4771 PF15995.5 EDO15310.1 - 0.051 13.8 0.1 0.11 12.8 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4771) IF4E PF01652.18 EDO15311.1 - 5.3e-55 185.6 0.7 6.3e-55 185.3 0.7 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E Hydrolase_4 PF12146.8 EDO15312.1 - 2.2e-13 50.1 0.0 6.5e-07 28.8 0.0 2.1 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EDO15312.1 - 4.2e-12 46.2 0.1 3.5e-06 26.9 0.0 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold FSH1 PF03959.13 EDO15312.1 - 2.6e-06 27.2 0.0 3.7e-06 26.8 0.0 1.2 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Peptidase_S9 PF00326.21 EDO15312.1 - 2.7e-05 23.8 0.0 7.3e-05 22.3 0.0 1.6 1 1 0 1 1 1 1 Prolyl oligopeptidase family BAAT_C PF08840.11 EDO15312.1 - 0.00029 20.8 0.1 0.028 14.3 0.1 2.3 1 1 1 2 2 2 1 BAAT / Acyl-CoA thioester hydrolase C terminal LIDHydrolase PF10230.9 EDO15312.1 - 0.0053 16.4 0.1 3.4 7.2 0.1 2.4 2 1 0 2 2 2 2 Lipid-droplet associated hydrolase DLH PF01738.18 EDO15312.1 - 0.021 14.4 0.0 0.12 11.9 0.0 1.9 1 1 0 1 1 1 0 Dienelactone hydrolase family PAE PF03283.13 EDO15312.1 - 0.033 13.3 0.0 0.052 12.7 0.0 1.2 1 0 0 1 1 1 0 Pectinacetylesterase DUF1057 PF06342.12 EDO15312.1 - 0.092 11.8 0.0 0.12 11.4 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF1057) Abhydrolase_6 PF12697.7 EDO15312.1 - 0.093 13.3 0.0 0.2 12.2 0.0 1.4 1 1 0 1 1 1 0 Alpha/beta hydrolase family AXE1 PF05448.12 EDO15312.1 - 0.13 10.9 0.0 14 4.3 0.0 2.4 3 0 0 3 3 3 0 Acetyl xylan esterase (AXE1) Abhydrolase_2 PF02230.16 EDO15312.1 - 0.14 11.9 0.2 6.2 6.5 0.0 2.2 1 1 1 2 2 2 0 Phospholipase/Carboxylesterase WD40 PF00400.32 EDO15313.1 - 5.8e-11 42.8 5.6 0.00018 22.2 0.1 4.5 6 0 0 6 6 6 2 WD domain, G-beta repeat Zn_ribbon_17 PF17120.5 EDO15313.1 - 3.2e-09 36.3 2.3 6.7e-09 35.2 2.3 1.5 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-RING_2 PF13639.6 EDO15313.1 - 0.00045 20.5 4.2 0.0011 19.2 4.2 1.7 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 EDO15313.1 - 0.0011 19.2 6.7 0.003 17.8 6.7 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger domain ATP13 PF12921.7 EDO15313.1 - 0.052 13.4 0.1 0.2 11.5 0.1 2.0 1 0 0 1 1 1 0 Mitochondrial ATPase expression ANAPC4_WD40 PF12894.7 EDO15313.1 - 0.13 12.6 0.1 44 4.5 0.0 3.2 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain zf-C3HC4 PF00097.25 EDO15313.1 - 0.48 10.3 8.3 0.1 12.5 3.5 2.3 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EDO15313.1 - 7.8 6.4 10.4 0.72 9.7 5.2 2.0 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Inhibitor_I9 PF05922.16 EDO15314.1 - 0.067 13.9 0.2 0.18 12.5 0.2 1.8 1 0 0 1 1 1 0 Peptidase inhibitor I9 ASF1_hist_chap PF04729.13 EDO15315.1 - 2.9e-72 241.6 0.0 4.4e-72 241.1 0.0 1.3 1 0 0 1 1 1 1 ASF1 like histone chaperone BUD22 PF09073.10 EDO15315.1 - 0.034 13.5 36.3 0.04 13.3 36.3 1.1 1 0 0 1 1 1 0 BUD22 Nop14 PF04147.12 EDO15315.1 - 0.24 9.6 39.6 0.28 9.4 39.6 1.1 1 0 0 1 1 1 0 Nop14-like family SUN PF03856.13 EDO15316.1 - 4.1e-96 321.2 13.2 4.1e-96 321.2 13.2 1.6 2 0 0 2 2 2 1 Beta-glucosidase (SUN family) zf-MYND PF01753.18 EDO15316.1 - 0.28 11.3 3.1 0.6 10.3 3.1 1.5 1 0 0 1 1 1 0 MYND finger Dehydrin PF00257.19 EDO15316.1 - 0.5 10.9 13.1 1.1 9.8 13.1 1.4 1 0 0 1 1 1 0 Dehydrin Mucin PF01456.17 EDO15316.1 - 1.4 8.9 26.5 3.1 7.8 26.5 1.6 1 0 0 1 1 1 0 Mucin-like glycoprotein His_Phos_1 PF00300.22 EDO15317.1 - 6.4e-33 114.1 0.1 8.3e-33 113.7 0.1 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) MOEP19 PF16005.5 EDO15317.1 - 0.013 15.5 0.0 0.022 14.7 0.0 1.3 1 0 0 1 1 1 0 KH-like RNA-binding domain Lectin_leg-like PF03388.13 EDO15318.1 - 5.7e-09 35.7 0.2 9e-06 25.2 0.1 2.3 2 0 0 2 2 2 2 Legume-like lectin family Pho86 PF11124.8 EDO15319.1 - 1.1e-110 369.7 0.4 1.2e-110 369.5 0.4 1.0 1 0 0 1 1 1 1 Inorganic phosphate transporter Pho86 PET10 PF17316.2 EDO15320.1 - 8.5e-93 310.5 15.4 8.5e-93 310.5 15.4 1.9 1 1 1 2 2 2 1 Petite colonies protein 10 DUF1687 PF07955.11 EDO15321.1 - 8.9e-27 94.1 0.7 1.1e-26 93.8 0.7 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1687) CN_hydrolase PF00795.22 EDO15322.1 - 1.7e-47 162.0 0.0 2.2e-47 161.6 0.0 1.2 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase zf-H2C2 PF09337.10 EDO15323.1 - 2.9e-14 53.0 2.5 4e-14 52.5 1.3 1.9 2 0 0 2 2 2 1 H2C2 zinc finger Integrase_H2C2 PF17921.1 EDO15323.1 - 3.8e-11 42.9 1.2 8.6e-11 41.8 1.2 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain Acetyltransf_1 PF00583.25 EDO15323.1 - 4.3e-06 27.0 0.0 1.2e-05 25.5 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_3 PF13302.7 EDO15323.1 - 0.022 15.4 0.0 0.061 14.0 0.0 1.8 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain DUF5310 PF17237.2 EDO15324.1 - 1.2e-23 82.7 2.3 1.3e-23 82.5 2.3 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF5310) Pkinase PF00069.25 EDO15325.1 - 4.2e-62 209.9 0.0 6.1e-62 209.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO15325.1 - 1.3e-37 129.5 0.0 1.9e-37 129.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDO15325.1 - 0.00027 20.4 0.0 0.00049 19.5 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Seadorna_VP7 PF07387.11 EDO15325.1 - 0.013 14.5 0.0 0.028 13.5 0.0 1.4 1 0 0 1 1 1 0 Seadornavirus VP7 DUF4587 PF15248.6 EDO15325.1 - 0.071 13.9 0.2 0.39 11.5 0.2 2.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4587) TrkH PF02386.16 EDO15326.1 - 2.4e-174 580.5 5.4 4e-173 576.4 0.2 2.2 2 0 0 2 2 2 2 Cation transport protein YL1 PF05764.13 EDO15326.1 - 1.1e-06 28.9 4.0 1.1e-06 28.9 4.0 4.1 2 1 1 3 3 3 1 YL1 nuclear protein SR-25 PF10500.9 EDO15326.1 - 0.0065 16.1 18.8 0.0065 16.1 18.8 4.0 3 1 1 4 4 4 1 Nuclear RNA-splicing-associated protein SEEEED PF14797.6 EDO15326.1 - 0.0079 16.4 20.0 0.0079 16.4 20.0 4.9 4 1 1 5 5 5 1 Serine-rich region of AP3B1, clathrin-adaptor complex CPSase_L_D2 PF02786.17 EDO15327.1 - 1.3e-115 384.2 1.3 2.6e-84 281.9 0.1 2.4 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_sm_chain PF00988.22 EDO15327.1 - 2.9e-49 166.2 0.0 7.4e-49 164.8 0.0 1.7 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain OTCace_N PF02729.21 EDO15327.1 - 9.6e-47 158.7 0.0 2e-46 157.6 0.0 1.6 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain GATase PF00117.28 EDO15327.1 - 1.2e-45 155.7 0.0 3e-45 154.4 0.0 1.8 1 0 0 1 1 1 1 Glutamine amidotransferase class-I CPSase_L_D3 PF02787.19 EDO15327.1 - 1.8e-38 131.6 0.1 4.3e-38 130.4 0.1 1.7 1 0 0 1 1 1 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain OTCace PF00185.24 EDO15327.1 - 2.7e-32 112.0 1.1 7e-31 107.4 0.2 3.2 3 0 0 3 3 3 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain MGS PF02142.22 EDO15327.1 - 4.9e-22 77.9 0.0 2.8e-21 75.5 0.0 2.5 2 0 0 2 2 1 1 MGS-like domain Dala_Dala_lig_C PF07478.13 EDO15327.1 - 4.5e-17 62.3 3.3 1.4e-09 37.8 0.6 2.5 2 0 0 2 2 2 2 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 EDO15327.1 - 1.5e-15 57.2 0.7 5.8e-08 32.5 0.2 2.5 2 0 0 2 2 2 2 ATP-grasp domain ATPgrasp_Ter PF15632.6 EDO15327.1 - 8.1e-12 45.0 0.1 1.4e-06 28.1 0.0 2.6 2 0 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon Peptidase_C26 PF07722.13 EDO15327.1 - 6.7e-06 26.0 0.0 0.00053 19.8 0.0 2.6 1 1 0 1 1 1 1 Peptidase C26 ATP-grasp_3 PF02655.14 EDO15327.1 - 7.3e-05 22.9 1.8 0.25 11.4 0.2 2.8 2 0 0 2 2 2 2 ATP-grasp domain DJ-1_PfpI PF01965.24 EDO15327.1 - 0.0013 18.5 0.4 0.19 11.5 0.0 4.0 5 0 0 5 5 5 1 DJ-1/PfpI family TrkA_N PF02254.18 EDO15327.1 - 0.026 14.8 0.9 0.1 12.9 0.1 2.5 2 0 0 2 2 2 0 TrkA-N domain ATP-grasp_5 PF13549.6 EDO15327.1 - 0.12 11.8 0.3 1.2 8.6 0.1 2.2 2 0 0 2 2 2 0 ATP-grasp domain mIF3 PF14877.6 EDO15328.1 - 2.5e-59 199.9 9.9 2.5e-59 199.9 9.9 2.2 2 0 0 2 2 2 1 Mitochondrial translation initiation factor PQQ PF01011.21 EDO15328.1 - 0.075 13.0 0.0 0.17 11.9 0.0 1.6 1 0 0 1 1 1 0 PQQ enzyme repeat Solute_trans_a PF03619.16 EDO15329.1 - 2.3e-74 250.3 18.4 3.2e-74 249.8 18.4 1.1 1 0 0 1 1 1 1 Organic solute transporter Ostalpha Mito_carr PF00153.27 EDO15330.1 - 2.7e-61 203.5 2.6 2.9e-21 75.2 0.1 3.0 2 1 1 3 3 3 3 Mitochondrial carrier protein SIR2 PF02146.17 EDO15331.1 - 4e-53 180.0 0.0 5.9e-53 179.4 0.0 1.3 1 0 0 1 1 1 1 Sir2 family CytB6-F_Fe-S PF08802.10 EDO15331.1 - 0.21 11.6 1.0 0.39 10.8 0.0 2.0 2 0 0 2 2 2 0 Cytochrome B6-F complex Fe-S subunit FYVE_2 PF02318.16 EDO15331.1 - 0.51 10.6 2.8 1 9.6 0.0 2.2 2 0 0 2 2 2 0 FYVE-type zinc finger Peptidase_C48 PF02902.19 EDO15332.1 - 1.2e-38 133.1 0.3 4e-38 131.4 0.3 1.9 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain NEXCaM_BD PF16644.5 EDO15332.1 - 0.037 14.3 0.8 0.14 12.4 0.8 2.0 1 0 0 1 1 1 0 Regulatory region of Na+/H+ exchanger NHE binds to calmodulin Fucose_iso_N2 PF07882.12 EDO15332.1 - 0.29 10.7 6.6 0.17 11.5 4.2 1.8 2 0 0 2 2 2 0 L-fucose isomerase, second N-terminal domain Ead_Ea22 PF13935.6 EDO15332.1 - 0.89 10.2 6.1 0.34 11.6 1.8 2.1 1 1 1 2 2 2 0 Ead/Ea22-like protein Ras PF00071.22 EDO15333.1 - 8.1e-64 214.1 0.4 9.7e-64 213.9 0.4 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EDO15333.1 - 9.1e-37 125.9 0.3 1.5e-36 125.3 0.3 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EDO15333.1 - 1.9e-19 69.8 0.3 2.4e-19 69.4 0.3 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 EDO15333.1 - 1.3e-07 31.3 0.2 1.6e-07 30.9 0.2 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 EDO15333.1 - 2.1e-07 30.6 0.1 2.5e-07 30.3 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EDO15333.1 - 2.2e-07 30.6 0.3 2.1e-06 27.4 0.1 2.1 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EDO15333.1 - 2.6e-07 30.7 0.2 0.0055 16.6 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 EDO15333.1 - 2.8e-06 27.4 0.1 4.8e-06 26.6 0.1 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EDO15333.1 - 6.7e-05 22.5 0.1 0.00056 19.5 0.1 2.0 1 1 0 1 1 1 1 Ferrous iron transport protein B MCM PF00493.23 EDO15333.1 - 0.0049 16.0 0.1 0.074 12.1 0.0 2.1 1 1 1 2 2 2 1 MCM P-loop domain AAA_22 PF13401.6 EDO15333.1 - 0.016 15.5 0.1 0.12 12.7 0.1 2.4 1 1 0 1 1 1 0 AAA domain AAA_7 PF12775.7 EDO15333.1 - 0.02 14.4 0.0 0.05 13.1 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_29 PF13555.6 EDO15333.1 - 0.022 14.5 0.1 0.085 12.6 0.1 2.0 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_16 PF13191.6 EDO15333.1 - 0.046 14.1 0.0 0.082 13.3 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain AAA PF00004.29 EDO15333.1 - 0.052 14.0 0.1 0.24 11.8 0.1 2.2 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) DUF815 PF05673.13 EDO15333.1 - 0.067 12.3 0.0 0.22 10.7 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA_24 PF13479.6 EDO15333.1 - 0.08 12.7 0.6 0.26 11.0 0.6 2.1 1 1 0 1 1 1 0 AAA domain TniB PF05621.11 EDO15333.1 - 0.13 11.6 0.0 0.31 10.4 0.0 1.6 1 0 0 1 1 1 0 Bacterial TniB protein BLM10_mid PF16507.5 EDO15334.1 - 5.7e-170 566.4 10.9 5.7e-170 566.4 10.9 3.0 3 0 0 3 3 3 1 Proteasome-substrate-size regulator, mid region BLM10_N PF16547.5 EDO15334.1 - 1.7e-30 105.1 0.2 9.8e-30 102.7 0.0 2.4 2 0 0 2 2 2 1 Proteasome-substrate-size regulator, N-terminal DUF3437 PF11919.8 EDO15334.1 - 1.7e-27 95.2 0.1 1.6e-26 92.0 0.0 2.8 2 0 0 2 2 2 1 Domain of unknown function (DUF3437) TAT_ubiq PF07706.12 EDO15334.1 - 0.19 12.0 0.6 0.38 11.0 0.6 1.5 1 0 0 1 1 1 0 Aminotransferase ubiquitination site SMC_N PF02463.19 EDO15335.1 - 3.5e-60 203.2 23.5 6.7e-60 202.3 23.5 1.6 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 EDO15335.1 - 9.1e-25 87.2 0.2 7.8e-24 84.2 0.0 2.6 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 EDO15335.1 - 1.7e-08 34.7 7.3 4.3e-06 26.7 0.4 5.1 2 2 1 5 5 5 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EDO15335.1 - 2.5e-08 33.5 0.1 4.8e-08 32.6 0.1 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_23 PF13476.6 EDO15335.1 - 4e-08 34.0 41.2 4e-08 34.0 41.2 6.9 2 2 2 4 4 4 1 AAA domain AAA_15 PF13175.6 EDO15335.1 - 6.8e-05 22.7 48.1 6.8e-05 22.7 48.1 4.3 2 2 2 4 4 4 1 AAA ATPase domain YnfE PF17452.2 EDO15335.1 - 0.001 19.3 1.1 0.001 19.3 1.1 3.7 3 1 1 4 4 4 1 Uncharacterized YnfE-like ABC_tran PF00005.27 EDO15335.1 - 0.012 16.2 0.2 0.012 16.2 0.2 6.1 3 3 0 4 4 4 0 ABC transporter Filament PF00038.21 EDO15335.1 - 0.075 12.6 97.1 0.027 14.0 28.2 5.9 3 2 2 5 5 5 0 Intermediate filament protein Baculo_PEP_C PF04513.12 EDO15335.1 - 0.72 9.9 29.8 0.31 11.1 3.7 5.9 5 0 0 5 5 5 0 Baculovirus polyhedron envelope protein, PEP, C terminus WD40 PF00400.32 EDO15336.1 - 2.1e-36 123.3 20.8 3.3e-07 30.9 0.1 8.1 8 0 0 8 8 8 6 WD domain, G-beta repeat CDC4_D PF16856.5 EDO15336.1 - 6.5e-21 74.0 2.2 1.4e-20 72.8 2.2 1.7 1 0 0 1 1 1 1 Cell division control protein 4 dimerisation domain F-box-like PF12937.7 EDO15336.1 - 6.4e-14 51.6 0.3 1.3e-13 50.6 0.3 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EDO15336.1 - 1.8e-07 30.9 0.0 4.4e-07 29.6 0.0 1.7 1 0 0 1 1 1 1 F-box domain ANAPC4_WD40 PF12894.7 EDO15336.1 - 2e-06 28.0 1.3 0.32 11.3 0.1 4.6 3 2 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EDO15336.1 - 0.00024 20.5 8.4 0.46 9.8 0.1 3.7 2 2 1 3 3 3 2 WD40-like domain WW PF00397.26 EDO15337.1 - 1.6e-08 34.5 0.9 5.6e-08 32.7 0.9 2.0 1 0 0 1 1 1 1 WW domain TFIIA PF03153.13 EDO15337.1 - 0.84 9.6 16.3 0.98 9.3 16.3 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DnaJ PF00226.31 EDO15339.1 - 4.6e-25 87.5 3.7 1.2e-24 86.2 3.7 1.8 1 0 0 1 1 1 1 DnaJ domain DnaJ_C PF01556.18 EDO15339.1 - 3.4e-24 85.6 0.1 6e-24 84.8 0.1 1.3 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.19 EDO15339.1 - 3.4e-13 49.8 17.0 7.1e-13 48.7 17.0 1.6 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 EDO15339.1 - 0.046 13.7 13.1 1.3 9.1 1.5 2.7 1 1 2 3 3 3 0 Tryptophan RNA-binding attenuator protein inhibitory protein FecR PF04773.13 EDO15339.1 - 0.057 14.0 0.0 0.16 12.6 0.0 1.8 1 0 0 1 1 1 0 FecR protein Cytochrome_C7 PF14522.6 EDO15339.1 - 0.13 12.3 16.0 2 8.5 2.3 2.4 1 1 1 2 2 2 0 Cytochrome c7 and related cytochrome c HypA PF01155.19 EDO15339.1 - 0.23 11.5 6.6 1.2 9.1 1.2 2.4 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Cytochrome_CBB3 PF13442.6 EDO15339.1 - 2.3 8.6 15.7 3.4 8.1 0.0 3.7 2 1 0 3 3 3 0 Cytochrome C oxidase, cbb3-type, subunit III A2L_zn_ribbon PF08792.10 EDO15339.1 - 8.5 6.2 10.8 7.4 6.4 0.5 3.5 3 0 0 3 3 3 0 A2L zinc ribbon domain Acetyltransf_1 PF00583.25 EDO15340.1 - 1.1e-14 54.6 0.1 1.5e-14 54.2 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EDO15340.1 - 2.5e-09 37.4 0.1 3.6e-09 36.9 0.1 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EDO15340.1 - 3.5e-08 33.4 0.0 4.8e-08 33.0 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 EDO15340.1 - 0.023 14.8 0.0 0.031 14.4 0.0 1.2 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain LSM PF01423.22 EDO15341.1 - 3.2e-18 65.2 0.1 3.5e-18 65.0 0.1 1.0 1 0 0 1 1 1 1 LSM domain Pyr_redox_2 PF07992.14 EDO15342.1 - 3.7e-68 229.9 4.2 5.2e-68 229.4 4.2 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 EDO15342.1 - 2e-42 143.9 0.0 5.4e-42 142.5 0.0 1.8 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 EDO15342.1 - 4.4e-21 75.2 3.7 3e-18 66.2 0.3 3.0 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EDO15342.1 - 7.5e-12 45.3 1.4 2.5e-05 24.4 0.3 2.7 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.7 EDO15342.1 - 1.6e-11 44.2 5.1 2.2e-10 40.5 0.2 2.7 2 1 1 3 3 3 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 EDO15342.1 - 6.2e-11 42.1 5.6 4.9e-08 32.6 0.1 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EDO15342.1 - 2.8e-09 36.6 6.1 2.7e-08 33.3 3.1 2.6 2 1 0 2 2 2 1 Glucose inhibited division protein A HI0933_like PF03486.14 EDO15342.1 - 8e-07 28.1 10.6 0.0002 20.2 0.8 4.0 3 1 1 4 4 4 3 HI0933-like protein FAD_binding_2 PF00890.24 EDO15342.1 - 1.1e-06 28.0 1.3 1.1e-06 28.0 1.3 3.0 2 1 1 3 3 3 1 FAD binding domain AlaDh_PNT_C PF01262.21 EDO15342.1 - 2.6e-06 26.9 1.8 0.013 14.8 0.1 2.5 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain FAD_binding_3 PF01494.19 EDO15342.1 - 5.1e-06 26.0 7.8 0.012 14.8 0.4 3.3 3 1 0 3 3 3 2 FAD binding domain K_oxygenase PF13434.6 EDO15342.1 - 2.7e-05 23.5 1.4 0.064 12.4 0.0 3.1 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) THF_DHG_CYH_C PF02882.19 EDO15342.1 - 0.00068 19.0 0.5 0.0054 16.1 0.1 2.4 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain DAO PF01266.24 EDO15342.1 - 0.0011 18.6 15.4 1 8.8 3.0 4.2 2 2 2 4 4 4 3 FAD dependent oxidoreductase Thi4 PF01946.17 EDO15342.1 - 0.0068 15.7 5.8 0.0078 15.5 0.7 2.4 1 1 0 2 2 2 1 Thi4 family 3HCDH_N PF02737.18 EDO15342.1 - 0.011 15.6 5.0 0.014 15.3 0.2 3.1 3 0 0 3 3 3 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain PTS_IIB PF02302.17 EDO15342.1 - 0.056 14.1 0.5 25 5.7 0.0 3.1 2 0 0 2 2 2 0 PTS system, Lactose/Cellobiose specific IIB subunit XdhC_C PF13478.6 EDO15342.1 - 0.086 13.3 0.0 22 5.6 0.0 2.6 2 0 0 2 2 2 0 XdhC Rossmann domain Lycopene_cycl PF05834.12 EDO15342.1 - 0.15 11.0 0.6 4.6 6.2 0.0 2.6 3 0 0 3 3 3 0 Lycopene cyclase protein RuBisCO_large PF00016.20 EDO15342.1 - 0.33 10.1 2.0 4.7 6.3 0.0 2.9 3 0 0 3 3 3 0 Ribulose bisphosphate carboxylase large chain, catalytic domain Trp_halogenase PF04820.14 EDO15342.1 - 0.59 8.9 2.5 1.5 7.6 0.4 2.1 2 0 0 2 2 2 0 Tryptophan halogenase Fcf2 PF08698.11 EDO15343.1 - 4.2e-33 113.6 2.6 4.2e-33 113.6 2.6 2.5 3 0 0 3 3 3 1 Fcf2 pre-rRNA processing HisK_sensor PF18698.1 EDO15343.1 - 0.13 12.6 1.6 0.14 12.6 0.5 1.6 2 0 0 2 2 2 0 Histidine kinase sensor domain Seryl_tRNA_N PF02403.22 EDO15343.1 - 0.3 11.3 4.1 6.1 7.1 0.2 2.3 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain tRNA-synt_2d PF01409.20 EDO15344.1 - 3.6e-90 301.7 0.0 4.5e-90 301.4 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II core domain (F) PheRS_DBD3 PF18553.1 EDO15344.1 - 6.2e-14 52.0 0.3 6.2e-14 52.0 0.3 2.0 2 0 0 2 2 2 1 PheRS DNA binding domain 3 tRNA_synthFbeta PF17759.1 EDO15344.1 - 1.5e-09 37.6 0.0 2.4e-06 27.2 0.0 2.2 2 0 0 2 2 2 2 Phenylalanyl tRNA synthetase beta chain CLM domain tRNA-synt_2b PF00587.25 EDO15344.1 - 3.2e-06 27.2 0.0 6e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) tRNA-synt_2 PF00152.20 EDO15344.1 - 3.1e-05 23.2 0.1 0.0009 18.4 0.0 2.7 3 0 0 3 3 3 1 tRNA synthetases class II (D, K and N) PheRS_DBD2 PF18554.1 EDO15344.1 - 4.4e-05 23.4 6.3 0.00011 22.1 6.3 1.8 1 0 0 1 1 1 1 PheRS DNA binding domain 2 HTH_45 PF14947.6 EDO15344.1 - 0.026 14.5 2.2 0.28 11.2 0.2 2.7 3 0 0 3 3 3 0 Winged helix-turn-helix PaaX PF07848.12 EDO15344.1 - 0.089 13.0 0.0 8.8 6.6 0.0 3.1 3 0 0 3 3 3 0 PaaX-like protein DUF465 PF04325.13 EDO15344.1 - 0.14 12.2 3.6 0.072 13.1 0.9 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF465) LTV PF04180.14 EDO15345.1 - 0.0014 18.5 10.8 0.0022 17.8 10.8 1.4 1 0 0 1 1 1 1 Low temperature viability protein Rtf2 PF04641.12 EDO15345.1 - 0.048 13.0 11.9 0.11 11.8 11.9 1.5 1 0 0 1 1 1 0 Rtf2 RING-finger CPSF100_C PF13299.6 EDO15345.1 - 0.5 10.5 6.4 1.2 9.3 6.4 1.5 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal RPN2_C PF18004.1 EDO15345.1 - 0.65 9.9 14.3 0.72 9.8 12.6 1.8 2 0 0 2 2 2 0 26S proteasome regulatory subunit RPN2 C-terminal domain AP3D1 PF06375.11 EDO15345.1 - 0.82 9.9 20.5 1.4 9.2 16.9 2.5 2 0 0 2 2 2 0 AP-3 complex subunit delta-1 DUF4638 PF15472.6 EDO15345.1 - 0.94 9.2 16.0 0.11 12.3 10.8 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4638) NST1 PF13945.6 EDO15345.1 - 3.2 7.8 25.2 0.13 12.3 18.5 2.1 2 0 0 2 2 2 0 Salt tolerance down-regulator Peptidase_S49_N PF08496.10 EDO15345.1 - 6.9 6.7 10.3 3 7.9 7.5 1.8 2 0 0 2 2 2 0 Peptidase family S49 N-terminal EPL1 PF10513.9 EDO15346.1 - 1.2e-24 87.5 2.4 1.2e-24 87.5 2.4 4.6 3 1 0 3 3 3 1 Enhancer of polycomb-like TFIIA PF03153.13 EDO15346.1 - 0.0011 19.1 27.5 0.0011 19.1 27.5 2.6 3 0 0 3 3 3 1 Transcription factor IIA, alpha/beta subunit DUF1512 PF07431.12 EDO15346.1 - 1 8.3 4.0 2 7.3 4.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1512) PepSY_TM PF03929.16 EDO15346.1 - 5.6 6.5 4.5 9.8 5.7 4.5 1.3 1 0 0 1 1 1 0 PepSY-associated TM region TetR_C_23 PF17931.1 EDO15346.1 - 7.3 6.7 8.0 34 4.6 8.0 2.2 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain STE2 PF02116.15 EDO15347.1 - 5.6e-87 291.6 29.8 6.8e-87 291.3 29.8 1.1 1 0 0 1 1 1 1 Fungal pheromone mating factor STE2 GPCR RabGAP-TBC PF00566.18 EDO15348.1 - 1.6e-18 67.2 3.5 3.5e-18 66.1 3.5 1.7 1 0 0 1 1 1 1 Rab-GTPase-TBC domain NRIP1_repr_1 PF15687.5 EDO15348.1 - 0.011 15.4 0.8 0.017 14.8 0.8 1.2 1 0 0 1 1 1 0 Nuclear receptor-interacting protein 1 repression 1 Gly_transf_sug PF04488.15 EDO15350.1 - 2.6e-24 85.7 1.6 1.1e-23 83.7 0.0 2.6 3 0 0 3 3 3 1 Glycosyltransferase sugar-binding region containing DXD motif DUF2401 PF10287.9 EDO15351.1 - 1.2e-82 276.9 4.9 1.9e-82 276.3 4.9 1.3 1 0 0 1 1 1 1 Putative TOS1-like glycosyl hydrolase (DUF2401) DUF2403 PF10290.9 EDO15351.1 - 6.2e-26 90.6 0.5 1.4e-25 89.5 0.5 1.6 1 0 0 1 1 1 1 Glycine-rich protein domain (DUF2403) RAMP4 PF06624.12 EDO15352.1 - 1.1e-10 41.5 0.4 1.3e-10 41.2 0.4 1.1 1 0 0 1 1 1 1 Ribosome associated membrane protein RAMP4 Glyco_transf_15 PF01793.16 EDO15353.1 - 2e-118 395.4 12.9 2.8e-118 394.9 12.9 1.2 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase NIF PF03031.18 EDO15354.1 - 1.7e-43 148.1 0.3 3.5e-43 147.1 0.1 1.6 2 0 0 2 2 2 1 NLI interacting factor-like phosphatase Pro_isomerase PF00160.21 EDO15355.1 - 0.0015 18.9 0.0 0.0074 16.6 0.0 2.1 1 1 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD VPS28 PF03997.12 EDO15356.1 - 1.2e-72 243.6 1.3 1.5e-72 243.3 1.3 1.1 1 0 0 1 1 1 1 VPS28 protein Arrestin_C PF02752.22 EDO15357.1 - 7.1e-05 23.3 1.8 0.0032 17.9 0.0 2.7 2 1 0 2 2 2 2 Arrestin (or S-antigen), C-terminal domain MCM PF00493.23 EDO15358.1 - 4.5e-104 346.4 0.0 7.1e-104 345.8 0.0 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 EDO15358.1 - 1.1e-31 109.3 1.2 2e-31 108.5 1.2 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 EDO15358.1 - 1.3e-22 80.0 2.1 2.7e-22 79.0 0.5 2.3 2 0 0 2 2 2 1 MCM AAA-lid domain MCM_N PF14551.6 EDO15358.1 - 4.5e-14 52.9 0.2 2.2e-13 50.7 0.2 2.3 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 EDO15358.1 - 3.1e-08 33.2 0.1 9.6e-06 25.1 0.0 2.3 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 EDO15358.1 - 2.1e-07 31.0 0.0 2.9e-06 27.3 0.0 2.8 3 1 0 3 3 3 1 AAA domain (dynein-related subfamily) Mg_chelatase_C PF13335.6 EDO15358.1 - 0.0078 16.8 0.2 0.038 14.6 0.1 2.2 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI C-terminal AAA_lid_2 PF17863.1 EDO15358.1 - 0.017 15.0 0.0 0.039 13.8 0.0 1.5 1 0 0 1 1 1 0 AAA lid domain AAA_3 PF07726.11 EDO15358.1 - 0.028 14.3 0.0 0.1 12.5 0.0 2.0 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA PF00004.29 EDO15358.1 - 0.069 13.6 0.1 0.78 10.2 0.0 2.7 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 EDO15358.1 - 0.077 12.7 0.1 0.53 10.0 0.0 2.2 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_16 PF13191.6 EDO15358.1 - 0.15 12.4 0.2 3.9 7.8 0.0 2.8 1 1 0 2 2 2 0 AAA ATPase domain DER1 PF04511.15 EDO15359.1 - 2.3e-34 119.0 12.0 2.6e-34 118.8 12.0 1.0 1 0 0 1 1 1 1 Der1-like family polyprenyl_synt PF00348.17 EDO15360.1 - 8.2e-55 185.6 0.2 1e-54 185.3 0.2 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase SH3_1 PF00018.28 EDO15361.1 - 7e-12 44.8 0.1 1.2e-08 34.4 0.0 2.7 3 0 0 3 3 3 2 SH3 domain PX PF00787.24 EDO15361.1 - 6e-11 42.3 0.0 1.3e-10 41.3 0.0 1.5 1 0 0 1 1 1 1 PX domain SH3_2 PF07653.17 EDO15361.1 - 2e-07 30.6 0.0 0.0055 16.4 0.0 2.6 2 0 0 2 2 2 2 Variant SH3 domain SH3_9 PF14604.6 EDO15361.1 - 3e-07 30.2 0.0 0.00032 20.5 0.0 2.5 2 0 0 2 2 2 2 Variant SH3 domain PB1 PF00564.24 EDO15361.1 - 2.8e-05 24.0 0.3 7.9e-05 22.5 0.3 1.8 1 0 0 1 1 1 1 PB1 domain GH97_C PF14509.6 EDO15361.1 - 0.019 15.2 0.0 0.051 13.8 0.0 1.7 1 0 0 1 1 1 0 Glycosyl-hydrolase 97 C-terminal, oligomerisation Styelin PF17562.2 EDO15361.1 - 0.12 12.7 0.0 0.33 11.4 0.0 1.7 1 0 0 1 1 1 0 Styelin Ribosomal_L30 PF00327.20 EDO15362.1 - 3.9e-11 42.6 1.3 8.8e-11 41.5 1.3 1.6 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e RFX_DNA_binding PF02257.15 EDO15363.1 - 1e-31 109.3 0.2 3.3e-31 107.7 0.2 1.9 1 0 0 1 1 1 1 RFX DNA-binding domain Radical_SAM_N PF08497.10 EDO15363.1 - 0.02 14.2 3.0 0.046 13.0 3.0 1.6 1 0 0 1 1 1 0 Radical SAM N-terminal SPK PF04435.18 EDO15363.1 - 0.17 12.3 1.6 1.1 9.8 0.1 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF545) DnaJ_C PF01556.18 EDO15364.1 - 9.9e-35 119.8 0.3 1.4e-34 119.4 0.3 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 EDO15364.1 - 2.9e-23 81.8 0.3 4.5e-23 81.2 0.3 1.3 1 0 0 1 1 1 1 DnaJ domain DUF3589 PF12141.8 EDO15365.1 - 4.2e-48 164.2 4.6 5.7e-27 94.5 3.2 2.5 1 1 0 2 2 2 2 Beta-mannosyltransferases PMSR PF01625.21 EDO15366.1 - 9.8e-51 171.9 0.3 1.2e-50 171.7 0.3 1.0 1 0 0 1 1 1 1 Peptide methionine sulfoxide reductase COX4 PF02936.14 EDO15367.1 - 1.1e-08 35.1 0.1 1.7e-08 34.6 0.1 1.4 1 0 0 1 1 1 1 Cytochrome c oxidase subunit IV Ost5 PF05251.12 EDO15368.1 - 2.4e-16 59.8 8.7 2.8e-16 59.5 8.7 1.1 1 0 0 1 1 1 1 Oligosaccharyltransferase subunit 5 DUF4064 PF13273.6 EDO15368.1 - 0.13 12.5 11.4 0.081 13.2 8.8 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF4064) SPRY PF00622.28 EDO15369.1 - 7.9e-23 80.9 2.2 1.1e-22 80.4 0.2 2.2 2 0 0 2 2 2 1 SPRY domain CLTH PF10607.9 EDO15369.1 - 1.5e-15 57.3 7.4 3.1e-15 56.3 7.4 1.5 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain LisH PF08513.11 EDO15369.1 - 0.035 14.1 0.0 1.5 8.9 0.0 2.5 2 0 0 2 2 2 0 LisH RNA_pol_3_Rpc31 PF11705.8 EDO15369.1 - 0.037 14.3 13.4 0.1 12.8 13.4 1.7 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 Nop14 PF04147.12 EDO15369.1 - 0.31 9.2 24.8 0.61 8.2 24.8 1.4 1 0 0 1 1 1 0 Nop14-like family PI3K_1B_p101 PF10486.9 EDO15369.1 - 3.8 5.2 9.3 6.5 4.4 9.3 1.3 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit SspB PF04386.13 EDO15369.1 - 9 6.2 8.2 20 5.0 8.2 1.5 1 0 0 1 1 1 0 Stringent starvation protein B AdoHcyase PF05221.17 EDO15370.1 - 2.1e-130 434.3 0.0 6.8e-75 252.0 0.4 2.0 1 1 1 2 2 2 2 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.21 EDO15370.1 - 8.1e-85 282.8 2.6 1.2e-84 282.2 2.6 1.3 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.19 EDO15370.1 - 3.4e-08 33.1 0.1 6.4e-08 32.2 0.1 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.12 EDO15370.1 - 0.0015 18.1 0.2 0.0029 17.2 0.2 1.4 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain TrkA_N PF02254.18 EDO15370.1 - 0.0025 18.1 0.1 0.0049 17.1 0.1 1.5 1 0 0 1 1 1 1 TrkA-N domain HSBP1 PF06825.12 EDO15371.1 - 1e-06 28.5 2.2 0.0011 18.8 0.2 3.0 2 0 0 2 2 2 2 Heat shock factor binding protein 1 Baculo_PEP_C PF04513.12 EDO15371.1 - 0.0065 16.5 10.6 1.7 8.7 0.2 4.0 4 0 0 4 4 4 2 Baculovirus polyhedron envelope protein, PEP, C terminus Vps54 PF07928.12 EDO15371.1 - 3.6 8.0 7.5 1.9 8.9 0.3 3.4 3 0 0 3 3 3 0 Vps54-like protein ApoO PF09769.9 EDO15371.1 - 9.7 6.2 8.3 8.4 6.4 0.1 3.8 3 1 0 3 3 3 0 Apolipoprotein O SAPS PF04499.15 EDO15372.1 - 6.1e-169 562.9 13.3 6.1e-169 562.9 13.3 2.5 2 1 0 2 2 2 1 SIT4 phosphatase-associated protein DnaJ PF00226.31 EDO15373.1 - 6.5e-14 51.8 6.2 9.9e-13 48.0 4.9 2.4 2 0 0 2 2 2 1 DnaJ domain DUF1878 PF08963.10 EDO15373.1 - 0.11 13.0 1.5 4.3 7.9 0.7 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1878) PEN-2 PF10251.9 EDO15374.1 - 8e-05 23.0 5.7 0.00023 21.5 2.9 2.3 2 1 0 2 2 2 1 Presenilin enhancer-2 subunit of gamma secretase Adaptin_binding PF10199.9 EDO15375.1 - 1.5e-09 38.5 3.9 0.0011 19.6 1.6 2.6 1 1 1 2 2 2 2 Alpha and gamma adaptin binding protein p34 SLD5_C PF16922.5 EDO15375.1 - 0.0063 16.7 0.2 0.099 12.8 0.0 2.6 2 1 0 2 2 2 1 DNA replication complex GINS protein SLD5 C-terminus BLYB PF05289.11 EDO15375.1 - 0.11 12.8 6.0 0.032 14.5 1.8 2.2 1 1 1 2 2 2 0 Borrelia hemolysin accessory protein DUF1077 PF06417.12 EDO15376.1 - 2.9e-43 146.6 3.0 3.5e-43 146.4 3.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1077) DUF21 PF01595.20 EDO15376.1 - 0.069 12.9 0.4 0.56 9.9 0.1 2.0 1 1 1 2 2 2 0 Cyclin M transmembrane N-terminal domain THUMP PF02926.17 EDO15377.1 - 4.4e-23 82.0 1.5 9.1e-23 81.0 1.5 1.5 1 0 0 1 1 1 1 THUMP domain Sec15 PF04091.12 EDO15378.1 - 1.6e-109 366.1 13.4 3.9e-109 364.9 13.4 1.7 1 0 0 1 1 1 1 Exocyst complex subunit Sec15-like Peptidase_M20 PF01546.28 EDO15379.1 - 3.2e-30 105.4 0.0 5.1e-30 104.7 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 EDO15379.1 - 5.7e-10 39.1 0.0 9.6e-10 38.4 0.0 1.4 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 EDO15379.1 - 0.013 15.2 0.0 0.023 14.4 0.0 1.2 1 0 0 1 1 1 0 Peptidase family M28 Mito_carr PF00153.27 EDO15380.1 - 1.6e-35 120.9 5.1 2.2e-18 65.9 0.2 3.4 3 1 0 3 3 3 3 Mitochondrial carrier protein GARS_A PF01071.19 EDO15381.1 - 2.3e-81 272.2 0.0 4.2e-81 271.4 0.0 1.4 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain GARS_N PF02844.15 EDO15381.1 - 1.1e-34 119.0 0.1 4.9e-34 117.0 0.0 2.2 2 0 0 2 2 2 1 Phosphoribosylglycinamide synthetase, N domain AIRS_C PF02769.22 EDO15381.1 - 3.8e-31 108.3 0.0 2.1e-30 105.9 0.0 2.2 2 0 0 2 2 2 1 AIR synthase related protein, C-terminal domain GARS_C PF02843.16 EDO15381.1 - 4.8e-28 97.3 0.2 1.1e-27 96.1 0.2 1.7 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, C domain AIRS PF00586.24 EDO15381.1 - 2.8e-17 63.1 1.5 3.8e-16 59.5 1.7 2.3 2 0 0 2 2 2 1 AIR synthase related protein, N-terminal domain ATP-grasp PF02222.22 EDO15381.1 - 1e-06 28.5 0.0 2e-06 27.5 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_3 PF02655.14 EDO15381.1 - 0.0003 20.9 0.2 0.0011 19.0 0.0 2.1 2 1 0 2 2 2 1 ATP-grasp domain CPSase_L_D2 PF02786.17 EDO15381.1 - 0.013 15.1 0.3 0.035 13.6 0.0 1.8 2 0 0 2 2 2 0 Carbamoyl-phosphate synthase L chain, ATP binding domain ATP-grasp_4 PF13535.6 EDO15381.1 - 0.067 12.8 0.0 0.14 11.7 0.0 1.5 1 0 0 1 1 1 0 ATP-grasp domain CENP-T_C PF15511.6 EDO15382.1 - 0.0006 19.9 0.0 0.0013 18.8 0.0 1.6 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold Cse1 PF08506.10 EDO15383.1 - 2.5e-166 553.1 4.6 5e-166 552.1 4.6 1.5 1 0 0 1 1 1 1 Cse1 CAS_CSE1 PF03378.15 EDO15383.1 - 6.3e-108 361.1 10.2 6.3e-108 361.1 8.9 1.7 2 0 0 2 2 2 1 CAS/CSE protein, C-terminus IBN_N PF03810.19 EDO15383.1 - 3.7e-17 62.0 0.3 8.8e-16 57.6 0.0 3.4 4 0 0 4 4 4 1 Importin-beta N-terminal domain Xpo1 PF08389.12 EDO15383.1 - 0.00014 21.9 3.3 0.012 15.6 0.1 3.8 3 0 0 3 3 3 2 Exportin 1-like protein DUF1955 PF09205.10 EDO15383.1 - 0.11 12.3 0.0 0.33 10.7 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF1955) ANAPC10 PF03256.16 EDO15384.1 - 2.6e-39 134.8 0.0 3.7e-39 134.3 0.0 1.2 1 0 0 1 1 1 1 Anaphase-promoting complex, subunit 10 (APC10) NifU PF01106.17 EDO15385.1 - 2.5e-26 91.6 0.1 4.4e-26 90.8 0.1 1.4 1 0 0 1 1 1 1 NifU-like domain Nfu_N PF08712.11 EDO15385.1 - 3.4e-24 84.7 0.1 8.2e-24 83.5 0.1 1.7 1 0 0 1 1 1 1 Scaffold protein Nfu/NifU N terminal YojJ PF10372.9 EDO15385.1 - 0.013 15.5 0.9 0.013 15.5 0.9 2.0 2 0 0 2 2 2 0 Bacterial membrane-spanning protein N-terminus Opi1 PF08618.10 EDO15386.1 - 4.1e-29 102.1 12.4 2.1e-15 56.9 0.0 3.1 2 1 1 3 3 3 3 Transcription factor Opi1 CLU PF13236.6 EDO15387.1 - 1.7e-65 220.9 0.1 4.6e-65 219.5 0.1 1.8 1 0 0 1 1 1 1 Clustered mitochondria eIF3_p135 PF12807.7 EDO15387.1 - 3.7e-32 111.8 0.0 2.1e-31 109.3 0.0 2.4 2 1 0 2 2 2 1 Translation initiation factor eIF3 subunit 135 CLU_N PF15044.6 EDO15387.1 - 8e-21 74.2 3.0 8e-21 74.2 3.0 2.9 2 1 1 3 3 3 1 Mitochondrial function, CLU-N-term TPR_12 PF13424.6 EDO15387.1 - 1.4e-08 34.9 0.8 0.0002 21.6 0.0 3.6 2 1 0 3 3 3 2 Tetratricopeptide repeat TPR_10 PF13374.6 EDO15387.1 - 1.6e-06 27.8 0.0 0.0027 17.5 0.0 3.8 4 0 0 4 4 4 1 Tetratricopeptide repeat DUF727 PF05303.12 EDO15387.1 - 0.01 15.9 0.1 0.066 13.3 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF727) TPR_1 PF00515.28 EDO15387.1 - 0.07 13.0 0.1 9.5 6.2 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat CbiG_N PF11760.8 EDO15387.1 - 0.19 11.8 0.0 0.44 10.6 0.0 1.6 1 0 0 1 1 1 0 Cobalamin synthesis G N-terminal TPR_8 PF13181.6 EDO15387.1 - 0.41 11.0 6.6 31 5.1 0.0 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat TCTP PF00838.17 EDO15387.1 - 1.7 9.0 7.1 0.42 10.9 1.9 2.4 2 0 0 2 2 2 0 Translationally controlled tumour protein BUD22 PF09073.10 EDO15388.1 - 8e-77 259.4 42.6 1e-76 259.0 42.6 1.1 1 0 0 1 1 1 1 BUD22 Spc42p PF11544.8 EDO15389.1 - 3.6e-32 110.2 12.4 3.6e-32 110.2 12.4 3.8 4 1 0 4 4 4 1 Spindle pole body component Spc42p Csm1_N PF18504.1 EDO15389.1 - 0.032 14.6 3.2 0.032 14.6 3.2 3.5 3 0 0 3 3 3 0 Csm1 N-terminal domain PKcGMP_CC PF16808.5 EDO15389.1 - 1 9.3 12.4 0.52 10.2 0.4 4.0 3 1 1 4 4 4 0 Coiled-coil N-terminus of cGMP-dependent protein kinase SlyX PF04102.12 EDO15389.1 - 2.9 8.6 12.6 5.5 7.7 0.7 4.1 3 2 1 4 4 4 0 SlyX DUF4407 PF14362.6 EDO15389.1 - 3.9 6.7 6.2 18 4.6 5.5 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) KilA-N PF04383.13 EDO15390.1 - 2e-05 24.4 1.7 0.00062 19.6 0.0 2.9 2 1 0 2 2 2 1 KilA-N domain Apq12 PF12716.7 EDO15391.1 - 8.2e-07 28.9 8.9 8.2e-07 28.9 8.9 1.8 2 0 0 2 2 2 1 Nuclear pore assembly and biogenesis Biotin_carb_C PF02785.19 EDO15391.1 - 0.095 12.8 0.0 0.14 12.3 0.0 1.2 1 0 0 1 1 1 0 Biotin carboxylase C-terminal domain DUF1516 PF07457.11 EDO15391.1 - 0.4 10.9 7.7 0.061 13.5 2.3 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1516) bZIP_2 PF07716.15 EDO15393.1 - 9.3e-09 35.2 6.4 4.2e-08 33.2 6.4 2.2 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.21 EDO15393.1 - 3e-08 33.6 5.4 3e-08 33.6 5.4 2.6 3 0 0 3 3 3 1 bZIP transcription factor bZIP_Maf PF03131.17 EDO15393.1 - 0.69 10.5 12.7 0.074 13.6 3.7 3.0 2 1 1 3 3 3 0 bZIP Maf transcription factor Pkinase PF00069.25 EDO15394.1 - 1.8e-56 191.4 7.3 3.1e-49 167.7 0.5 2.1 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EDO15394.1 - 4.3e-17 62.2 2.2 5.3e-14 52.1 2.2 2.4 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EDO15394.1 - 7.5e-06 26.0 0.1 4.6e-05 23.5 0.1 2.0 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 EDO15394.1 - 0.0039 16.6 0.2 0.009 15.4 0.2 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EDO15394.1 - 0.013 14.2 0.9 0.02 13.7 0.0 1.7 2 0 0 2 2 2 0 Fungal protein kinase RNA_binding PF01877.17 EDO15394.1 - 0.04 14.2 1.1 0.082 13.2 0.8 1.7 2 0 0 2 2 2 0 RNA binding Choline_kinase PF01633.20 EDO15394.1 - 0.045 13.3 0.1 0.045 13.3 0.1 2.1 3 0 0 3 3 3 0 Choline/ethanolamine kinase F_actin_cap_B PF01115.17 EDO15395.1 - 7e-94 313.9 0.5 8.1e-94 313.7 0.5 1.0 1 0 0 1 1 1 1 F-actin capping protein, beta subunit SNF2_N PF00176.23 EDO15396.1 - 1.2e-67 228.1 0.9 2.3e-67 227.2 0.9 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EDO15396.1 - 5.2e-20 71.9 0.0 4.1e-19 69.0 0.0 2.6 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDO15396.1 - 1.1e-07 32.0 0.0 1.1e-07 32.0 0.0 3.3 3 2 1 5 5 5 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EDO15396.1 - 0.00038 20.3 0.0 0.0013 18.5 0.0 2.1 1 0 0 1 1 1 1 DEAD/DEAH box helicase ERCC3_RAD25_C PF16203.5 EDO15396.1 - 0.0014 17.9 0.2 0.0062 15.8 0.0 2.2 1 1 1 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase SWIRM PF04433.17 EDO15397.1 - 3.6e-28 97.8 0.2 1.3e-27 96.0 0.2 2.0 1 0 0 1 1 1 1 SWIRM domain ZZ PF00569.17 EDO15397.1 - 5.5e-11 42.1 2.6 9.2e-11 41.4 2.6 1.3 1 0 0 1 1 1 1 Zinc finger, ZZ type Myb_DNA-binding PF00249.31 EDO15397.1 - 9.8e-10 38.5 0.1 1.9e-09 37.5 0.1 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain SWIRM-assoc_1 PF16495.5 EDO15397.1 - 1.8e-08 34.2 4.8 4.8e-08 32.8 4.8 1.8 1 0 0 1 1 1 1 SWIRM-associated region 1 Myb_DNA-bind_6 PF13921.6 EDO15397.1 - 9e-07 29.1 0.3 4.2e-06 26.9 0.1 2.3 2 0 0 2 2 2 1 Myb-like DNA-binding domain zf-UBR PF02207.20 EDO15397.1 - 0.0084 16.3 0.3 0.016 15.4 0.3 1.4 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) zf-CCHC_2 PF13696.6 EDO15397.1 - 0.015 15.1 2.5 0.71 9.7 0.2 2.3 2 0 0 2 2 2 0 Zinc knuckle DUF2786 PF10979.8 EDO15397.1 - 1 9.3 4.1 3.2 7.8 0.1 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF2786) Peptidase_C48 PF02902.19 EDO15398.1 - 2e-29 103.0 0.7 2e-29 103.0 0.7 2.6 3 0 0 3 3 3 1 Ulp1 protease family, C-terminal catalytic domain Tim44 PF04280.15 EDO15399.1 - 3.6e-38 131.0 0.1 8.9e-38 129.7 0.0 1.7 2 0 0 2 2 2 1 Tim44-like domain His_biosynth PF00977.21 EDO15401.1 - 8.5e-07 28.7 0.0 1e-06 28.4 0.0 1.1 1 0 0 1 1 1 1 Histidine biosynthesis protein His_biosynth PF00977.21 EDO15402.1 - 0.0054 16.2 0.0 0.0059 16.1 0.0 1.0 1 0 0 1 1 1 1 Histidine biosynthesis protein Mak16 PF04874.14 EDO15403.1 - 2.1 9.0 20.3 10 6.8 1.1 2.9 2 0 0 2 2 2 0 Mak16 protein C-terminal region HLH PF00010.26 EDO15404.1 - 7.8e-12 45.0 1.2 1.9e-11 43.8 1.2 1.7 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain UCR_hinge PF02320.16 EDO15405.1 - 6.8e-23 80.7 2.4 1.1e-22 79.9 2.4 1.4 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase hinge protein Sigma70_ner PF04546.13 EDO15405.1 - 0.016 15.1 13.0 0.02 14.8 13.0 1.1 1 0 0 1 1 1 0 Sigma-70, non-essential region Nop14 PF04147.12 EDO15405.1 - 0.083 11.1 15.5 0.092 11.0 15.5 1.0 1 0 0 1 1 1 0 Nop14-like family PDDEXK_6 PF04720.12 EDO15405.1 - 0.15 12.0 6.1 0.16 11.9 6.1 1.1 1 0 0 1 1 1 0 PDDEXK-like family of unknown function GCIP PF13324.6 EDO15405.1 - 0.16 11.6 10.2 0.19 11.3 10.2 1.1 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting CDC45 PF02724.14 EDO15405.1 - 0.24 9.7 12.4 0.25 9.6 12.4 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF4211 PF13926.6 EDO15405.1 - 0.24 11.4 4.4 0.3 11.1 4.2 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4211) ATG22 PF11700.8 EDO15405.1 - 0.57 8.7 1.9 6.6 5.2 0.3 2.0 1 1 1 2 2 2 0 Vacuole effluxer Atg22 like RPN2_C PF18004.1 EDO15405.1 - 0.8 9.6 6.2 0.99 9.3 6.2 1.2 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Cwf_Cwc_15 PF04889.12 EDO15405.1 - 1 9.0 15.5 1.2 8.9 15.5 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DNA_pol_phi PF04931.13 EDO15405.1 - 1.4 7.0 18.4 1.4 6.9 18.4 1.1 1 0 0 1 1 1 0 DNA polymerase phi Na_trans_assoc PF06512.13 EDO15405.1 - 1.5 9.0 14.3 1.8 8.8 14.3 1.1 1 0 0 1 1 1 0 Sodium ion transport-associated Drc1-Sld2 PF11719.8 EDO15405.1 - 1.8 8.0 8.0 2.3 7.7 8.0 1.1 1 0 0 1 1 1 0 DNA replication and checkpoint protein CENP-T_N PF16171.5 EDO15405.1 - 2.4 7.0 4.9 2.7 6.8 4.9 1.1 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T N-terminus RRN3 PF05327.11 EDO15405.1 - 2.4 6.6 11.7 2.6 6.5 11.7 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 DUF4611 PF15387.6 EDO15405.1 - 2.8 8.2 17.0 0.84 9.9 14.0 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4611) DUF2457 PF10446.9 EDO15405.1 - 4.6 6.3 19.1 4.9 6.2 19.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) SDA1 PF05285.12 EDO15405.1 - 5.6 6.3 15.0 6.2 6.1 15.0 1.1 1 0 0 1 1 1 0 SDA1 Dicty_REP PF05086.12 EDO15405.1 - 8.2 4.3 11.2 11 3.9 11.2 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Ribosomal_L29e PF01779.17 EDO15406.1 - 7.7e-24 83.7 9.4 1.1e-23 83.3 9.4 1.2 1 0 0 1 1 1 1 Ribosomal L29e protein family RRM_1 PF00076.22 EDO15407.1 - 2.8e-17 62.3 0.0 7.9e-10 38.4 0.0 2.9 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Ribosomal_L2_C PF03947.18 EDO15408.1 - 2.7e-44 150.4 4.1 4.9e-44 149.6 4.1 1.4 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 EDO15408.1 - 1.4e-13 50.6 0.2 3.7e-13 49.2 0.2 1.7 1 0 0 1 1 1 1 Ribosomal Proteins L2, RNA binding domain SMC_N PF02463.19 EDO15409.1 - 5.3e-69 232.0 20.2 5.5e-39 133.9 9.3 3.6 2 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 EDO15409.1 - 4.2e-19 69.0 0.2 1.1e-18 67.6 0.2 1.8 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_23 PF13476.6 EDO15409.1 - 1.3e-16 61.7 0.7 1.3e-16 61.7 0.7 6.5 2 2 3 5 5 5 1 AAA domain AAA_15 PF13175.6 EDO15409.1 - 6.3e-11 42.6 6.1 6.3e-11 42.6 6.1 4.6 2 2 2 4 4 4 1 AAA ATPase domain AAA_21 PF13304.6 EDO15409.1 - 1.1e-07 32.0 15.8 6.9e-05 22.8 0.4 3.5 3 1 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EDO15409.1 - 4.3e-05 23.2 0.0 0.00013 21.6 0.0 1.8 1 0 0 1 1 1 1 P-loop containing region of AAA domain GAS PF13851.6 EDO15409.1 - 0.0035 16.7 14.5 0.0035 16.7 14.5 8.0 3 2 5 8 8 8 2 Growth-arrest specific micro-tubule binding ABC_tran PF00005.27 EDO15409.1 - 0.66 10.5 0.0 0.66 10.5 0.0 6.6 4 2 2 6 6 6 0 ABC transporter YgbB PF02542.16 EDO15409.1 - 5 7.4 6.7 0.79 10.0 0.8 2.6 2 0 0 2 2 2 0 YgbB family YvbH_ext PF11724.8 EDO15409.1 - 7.1 7.0 11.2 7.4 7.0 0.1 4.4 4 0 0 4 4 4 0 YvbH-like oligomerisation region BAG PF02179.16 EDO15410.1 - 3.9e-15 56.0 2.2 6.9e-15 55.2 2.2 1.4 1 0 0 1 1 1 1 BAG domain Salp15 PF12115.8 EDO15410.1 - 0.0099 16.3 0.1 0.014 15.9 0.1 1.2 1 0 0 1 1 1 1 Salivary protein of 15kDa inhibits CD4+ T cell activation UBA_e1_thiolCys PF10585.9 EDO15410.1 - 0.016 15.2 0.1 0.025 14.5 0.1 1.3 1 0 0 1 1 1 0 Ubiquitin-activating enzyme active site APC_u14 PF16635.5 EDO15410.1 - 3.2 8.4 9.2 18 5.9 9.2 2.0 1 1 0 1 1 1 0 Unstructured region on APC between SAMP and APC_crr Asp PF00026.23 EDO15411.1 - 6.1e-49 167.1 2.2 7.5e-49 166.9 2.2 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EDO15411.1 - 5.9e-15 55.9 0.6 5.9e-15 55.9 0.6 1.9 2 0 0 2 2 2 1 Xylanase inhibitor N-terminal gag-asp_proteas PF13975.6 EDO15411.1 - 2.5e-05 24.7 0.0 0.63 10.6 0.0 3.3 3 0 0 3 3 3 2 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 EDO15411.1 - 0.00013 22.5 0.3 9.9 6.9 0.0 3.3 3 0 0 3 3 3 3 Aspartyl protease Peptidase_C54 PF03416.19 EDO15412.1 - 1.8e-83 280.1 0.0 2.2e-83 279.9 0.0 1.1 1 0 0 1 1 1 1 Peptidase family C54 HIGH_NTase1_ass PF16581.5 EDO15412.1 - 0.23 11.4 1.7 1 9.3 0.0 2.3 3 0 0 3 3 3 0 Cytidyltransferase-related C-terminal region G-patch PF01585.23 EDO15413.1 - 1.1e-11 44.4 0.4 2.9e-11 43.1 0.4 1.8 1 0 0 1 1 1 1 G-patch domain R3H PF01424.22 EDO15413.1 - 0.0056 16.6 0.0 0.017 15.1 0.0 1.9 1 0 0 1 1 1 1 R3H domain CRAL_TRIO PF00650.20 EDO15414.1 - 3.1e-39 134.2 0.0 4.8e-39 133.6 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 EDO15414.1 - 3.2e-19 68.8 0.5 6.1e-19 68.0 0.5 1.5 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain EXOSC1 PF10447.9 EDO15415.1 - 6.1e-41 139.4 0.4 1.3e-40 138.4 0.0 1.7 2 0 0 2 2 2 1 Exosome component EXOSC1/CSL4 Methyltransf_21 PF05050.12 EDO15415.1 - 0.082 12.9 0.3 0.17 11.9 0.3 1.5 1 0 0 1 1 1 0 Methyltransferase FkbM domain ECR1_N PF14382.6 EDO15415.1 - 0.18 11.6 0.6 12 5.8 0.0 2.9 3 0 0 3 3 3 0 Exosome complex exonuclease RRP4 N-terminal region PDZ_5 PF17817.1 EDO15416.1 - 0.026 14.8 0.4 0.15 12.3 0.0 2.5 2 0 0 2 2 2 0 PDZ domain DUF166 PF02593.14 EDO15416.1 - 0.039 13.5 0.4 0.08 12.5 0.4 1.4 1 0 0 1 1 1 0 Domain of unknown function Med16 PF11635.8 EDO15417.1 - 3.5e-238 792.4 10.2 4.1e-238 792.2 10.2 1.0 1 0 0 1 1 1 1 Mediator complex subunit 16 Ytp1 PF10355.9 EDO15418.1 - 5.6e-56 189.8 21.3 9.9e-54 182.4 21.3 2.4 1 1 0 1 1 1 1 Protein of unknown function (Ytp1) Peptidase_S8 PF00082.22 EDO15419.1 - 8.2e-40 136.9 0.2 1.1e-39 136.6 0.2 1.1 1 0 0 1 1 1 1 Subtilase family Peptidase_C1_2 PF03051.15 EDO15420.1 - 3.8e-166 553.2 3.1 4.3e-166 553.0 3.1 1.0 1 0 0 1 1 1 1 Peptidase C1-like family Peptidase_C1 PF00112.23 EDO15420.1 - 8.9e-06 25.9 0.1 0.098 12.7 0.2 2.3 2 0 0 2 2 2 2 Papain family cysteine protease Fe_hyd_lg_C PF02906.14 EDO15421.1 - 5.5e-65 219.4 0.0 9.3e-65 218.7 0.0 1.4 1 0 0 1 1 1 1 Iron only hydrogenase large subunit, C-terminal domain RinB PF06116.12 EDO15421.1 - 0.11 12.5 0.1 0.24 11.5 0.1 1.5 1 0 0 1 1 1 0 Transcriptional activator RinB G6PD_C PF02781.16 EDO15422.1 - 5.5e-110 367.1 0.0 7.8e-110 366.6 0.0 1.2 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, C-terminal domain G6PD_N PF00479.22 EDO15422.1 - 5.9e-60 202.9 0.0 9.7e-60 202.2 0.0 1.3 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, NAD binding domain Mannosyl_trans3 PF11051.8 EDO15423.1 - 1.4e-79 267.3 1.9 1.4e-79 267.3 1.9 2.0 2 0 0 2 2 2 1 Mannosyltransferase putative DUF3575 PF12099.8 EDO15423.1 - 0.014 14.8 1.3 0.025 13.9 0.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3575) Aida_C2 PF14186.6 EDO15424.1 - 0.041 13.5 0.4 0.52 9.9 0.2 2.3 2 1 1 3 3 3 0 Cytoskeletal adhesion Pkinase PF00069.25 EDO15427.1 - 6.8e-45 153.5 0.0 3.6e-38 131.5 0.0 2.4 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EDO15427.1 - 2.4e-18 66.4 0.0 5.2e-18 65.3 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EDO15427.1 - 0.0075 15.6 0.0 0.022 14.1 0.0 1.7 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EDO15427.1 - 0.039 13.3 0.1 0.34 10.2 0.0 2.1 2 0 0 2 2 2 0 Kinase-like 4_1_CTD PF05902.13 EDO15427.1 - 0.052 13.6 4.9 0.15 12.1 4.9 1.7 1 0 0 1 1 1 0 4.1 protein C-terminal domain (CTD) Ribonucleas_3_3 PF14622.6 EDO15428.1 - 2.4e-16 60.1 0.0 3.5e-16 59.5 0.0 1.3 1 0 0 1 1 1 1 Ribonuclease-III-like Ribonuclease_3 PF00636.26 EDO15428.1 - 0.012 16.2 0.1 0.032 14.8 0.0 1.8 2 0 0 2 2 2 0 Ribonuclease III domain GIT_SHD PF08518.11 EDO15429.1 - 7.5e-25 86.2 2.3 8.8e-13 47.6 0.3 2.6 2 0 0 2 2 2 2 Spa2 homology domain (SHD) of GIT GIT1_C PF12205.8 EDO15429.1 - 6.7e-07 29.4 0.6 6.7e-07 29.4 0.6 2.0 2 0 0 2 2 2 1 G protein-coupled receptor kinase-interacting protein 1 C term YabA PF06156.13 EDO15429.1 - 9 7.0 16.0 0.061 14.0 1.0 4.3 4 0 0 4 4 4 0 Initiation control protein YabA Septin PF00735.18 EDO15430.1 - 1.6e-106 355.7 7.9 1.6e-106 355.7 7.9 3.0 2 1 0 2 2 2 1 Septin MMR_HSR1 PF01926.23 EDO15430.1 - 0.0016 18.5 5.4 0.0016 18.5 5.4 2.2 2 1 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EDO15430.1 - 0.015 15.2 8.7 0.019 14.9 0.1 3.5 4 0 0 4 4 4 0 RsgA GTPase AAA_22 PF13401.6 EDO15430.1 - 0.037 14.3 0.5 0.37 11.1 0.0 2.8 3 1 0 3 3 3 0 AAA domain Strep_SA_rep PF06696.11 EDO15430.1 - 2 8.5 5.4 1.5 8.9 0.3 2.5 2 0 0 2 2 2 0 Streptococcal surface antigen repeat Peptidase_M20 PF01546.28 EDO15431.1 - 1.8e-23 83.3 0.0 4.4e-23 82.1 0.0 1.6 2 0 0 2 2 2 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 EDO15431.1 - 1.4e-10 41.1 0.0 2.3e-10 40.3 0.0 1.3 1 0 0 1 1 1 1 Peptidase dimerisation domain WD40 PF00400.32 EDO15431.1 - 2.7e-09 37.5 7.1 0.27 12.2 0.0 6.0 5 1 0 5 5 5 3 WD domain, G-beta repeat Nup160 PF11715.8 EDO15431.1 - 0.0037 16.0 0.0 0.49 9.0 0.0 2.4 2 0 0 2 2 2 2 Nucleoporin Nup120/160 Thermopsin PF05317.11 EDO15431.1 - 0.047 13.1 0.0 0.11 12.0 0.0 1.5 1 0 0 1 1 1 0 Thermopsin MRP-L27 PF09809.9 EDO15432.1 - 3e-31 107.6 1.6 4.3e-31 107.1 1.6 1.2 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L27 SecY PF00344.20 EDO15433.1 - 1.1e-15 57.7 0.6 1.2e-15 57.6 0.6 1.0 1 0 0 1 1 1 1 SecY translocase SecY PF00344.20 EDO15434.1 - 6.2e-19 68.4 4.5 7.7e-19 68.1 4.5 1.1 1 0 0 1 1 1 1 SecY translocase Plug_translocon PF10559.9 EDO15434.1 - 1.2e-10 41.1 2.8 8.2e-10 38.4 0.1 2.8 2 0 0 2 2 2 1 Plug domain of Sec61p DUF4173 PF13777.6 EDO15434.1 - 0.032 13.6 2.2 0.047 13.1 2.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4173) A_deaminase PF00962.22 EDO15435.1 - 3e-23 82.7 0.1 8.9e-11 41.7 0.0 4.4 4 1 0 4 4 4 3 Adenosine/AMP deaminase Staygreen PF12638.7 EDO15435.1 - 0.0062 16.3 0.5 0.014 15.2 0.5 1.5 1 0 0 1 1 1 1 Staygreen protein NAT PF04768.13 EDO15436.1 - 1.4e-54 184.3 0.0 3.3e-54 183.1 0.0 1.7 1 0 0 1 1 1 1 NAT, N-acetyltransferase, of N-acetylglutamate synthase Baculo_PEP_C PF04513.12 EDO15436.1 - 0.0024 17.9 1.3 0.0024 17.9 1.3 2.1 3 0 0 3 3 3 1 Baculovirus polyhedron envelope protein, PEP, C terminus DUF5126 PF17166.4 EDO15436.1 - 0.02 14.8 0.0 0.06 13.2 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF5126) EcoEI_R_C PF08463.10 EDO15436.1 - 0.1 12.7 0.3 0.28 11.3 0.3 1.7 1 0 0 1 1 1 0 EcoEI R protein C-terminal Sld5 PF05916.11 EDO15437.1 - 5.7e-18 65.4 2.5 5.7e-18 65.4 2.5 1.7 2 0 0 2 2 2 1 GINS complex protein Peptidase_M28 PF04389.17 EDO15438.1 - 2e-35 122.3 0.1 3.4e-35 121.5 0.1 1.4 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.22 EDO15438.1 - 2.2e-08 34.0 0.0 4.4e-08 33.0 0.0 1.5 1 0 0 1 1 1 1 PA domain Peptidase_M20 PF01546.28 EDO15438.1 - 0.00076 19.2 0.0 0.0012 18.5 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 Peptidase_M42 PF05343.14 EDO15438.1 - 0.016 14.2 0.0 0.026 13.6 0.0 1.3 1 0 0 1 1 1 0 M42 glutamyl aminopeptidase DnaJ PF00226.31 EDO15439.1 - 1.6e-21 76.1 4.1 1e-20 73.6 4.1 2.5 1 0 0 1 1 1 1 DnaJ domain TFIIA PF03153.13 EDO15439.1 - 0.021 14.8 11.0 0.032 14.2 11.0 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Band_3_cyto PF07565.13 EDO15439.1 - 1.2 8.9 4.1 2.1 8.1 4.1 1.3 1 0 0 1 1 1 0 Band 3 cytoplasmic domain PAPA-1 PF04795.12 EDO15439.1 - 3.3 8.6 6.8 0.48 11.3 1.7 2.2 3 0 0 3 3 3 0 PAPA-1-like conserved region RhlB PF12300.8 EDO15439.1 - 5.6 7.1 5.7 8.7 6.4 5.7 1.2 1 0 0 1 1 1 0 ATP-dependent RNA helicase RhlB Pex14_N PF04695.13 EDO15439.1 - 6 7.5 10.2 5.1 7.7 8.6 1.7 1 1 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region MBOAT PF03062.19 EDO15440.1 - 2.9e-79 266.9 40.7 3.9e-79 266.5 40.7 1.1 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family MBOAT_2 PF13813.6 EDO15440.1 - 0.00072 19.8 4.9 0.002 18.3 4.9 1.8 1 0 0 1 1 1 1 Membrane bound O-acyl transferase family E1-E2_ATPase PF00122.20 EDO15440.1 - 0.35 10.4 1.4 5.3 6.5 0.1 2.6 2 1 1 3 3 3 0 E1-E2 ATPase Lipoprotein_17 PF04200.12 EDO15440.1 - 0.56 10.6 3.0 5.9 7.3 0.1 2.7 3 0 0 3 3 3 0 Lipoprotein associated domain Peptidase_M76 PF09768.9 EDO15441.1 - 6e-70 234.5 0.2 7.5e-70 234.1 0.2 1.1 1 0 0 1 1 1 1 Peptidase M76 family Tox-MPTase2 PF15638.6 EDO15441.1 - 0.13 12.0 0.0 0.19 11.5 0.0 1.2 1 0 0 1 1 1 0 Metallopeptidase toxin 2 PH PF00169.29 EDO15442.1 - 0.00018 22.0 0.1 0.0075 16.8 0.1 2.8 1 1 0 1 1 1 1 PH domain PH_9 PF15410.6 EDO15442.1 - 0.0011 19.3 0.1 0.0044 17.4 0.1 2.0 1 1 0 1 1 1 1 Pleckstrin homology domain SprA-related PF12118.8 EDO15442.1 - 0.79 8.8 7.4 1.6 7.8 7.4 1.5 1 0 0 1 1 1 0 SprA-related family Pga1 PF10333.9 EDO15443.1 - 1.7e-66 223.4 9.7 1.9e-66 223.2 9.7 1.0 1 0 0 1 1 1 1 GPI-Mannosyltransferase II co-activator VacA PF02691.15 EDO15443.1 - 0.016 13.1 0.1 0.017 13.0 0.1 1.1 1 0 0 1 1 1 0 Vacuolating cyotoxin DUF4896 PF16237.5 EDO15443.1 - 0.41 10.5 9.5 1.4 8.9 2.9 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4896) zf-AN1 PF01428.16 EDO15444.1 - 1.1e-10 41.5 15.6 1.7e-10 40.9 15.6 1.3 1 0 0 1 1 1 1 AN1-like Zinc finger Phage_GP20 PF06810.11 EDO15444.1 - 0.0031 17.3 5.5 0.0062 16.3 5.5 1.5 1 0 0 1 1 1 1 Phage minor structural protein GP20 DUF3818 PF12825.7 EDO15444.1 - 0.046 12.7 4.0 0.058 12.4 4.0 1.2 1 0 0 1 1 1 0 Domain of unknown function in PX-proteins (DUF3818) PSI_integrin PF17205.3 EDO15444.1 - 0.25 11.1 7.0 2.5 7.9 7.0 2.3 1 1 0 1 1 1 0 Integrin plexin domain UPF1_Zn_bind PF09416.10 EDO15444.1 - 3.7 7.5 14.2 5.3 7.0 5.9 2.4 2 1 0 2 2 2 0 RNA helicase (UPF2 interacting domain) Pkinase PF00069.25 EDO15445.1 - 1.3e-24 87.0 0.0 2.4e-24 86.1 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO15445.1 - 2.2e-12 46.8 0.0 5.8e-12 45.4 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EDO15445.1 - 4.3e-10 38.9 0.0 4.3e-10 38.9 0.0 2.0 2 0 0 2 2 2 1 Fungal protein kinase SOG2 PF10428.9 EDO15445.1 - 0.0032 16.8 4.7 0.0032 16.8 4.7 2.0 2 0 0 2 2 2 1 RAM signalling pathway protein Kdo PF06293.14 EDO15445.1 - 0.0064 15.9 0.9 0.0084 15.5 0.0 1.6 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EDO15445.1 - 0.031 14.2 0.1 0.44 10.4 0.1 2.3 1 1 1 2 2 2 0 Phosphotransferase enzyme family Mrpl_C PF18502.1 EDO15447.1 - 1.5e-32 112.2 0.3 3.1e-32 111.1 0.3 1.5 1 0 0 1 1 1 1 54S ribosomal protein L8 C-terminal domain Ribosomal_L17 PF01196.19 EDO15447.1 - 6e-24 84.8 0.0 1.1e-23 83.9 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L17 CBFD_NFYB_HMF PF00808.23 EDO15448.1 - 7e-05 23.0 0.2 0.00016 21.9 0.2 1.7 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EDO15448.1 - 0.0015 18.9 0.1 0.0015 18.9 0.1 2.0 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 Myc_N PF01056.18 EDO15448.1 - 0.0026 17.7 8.2 0.0032 17.4 8.2 1.3 1 0 0 1 1 1 1 Myc amino-terminal region CDC27 PF09507.10 EDO15448.1 - 0.095 12.1 17.0 0.09 12.2 17.0 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 DUF913 PF06025.12 EDO15448.1 - 0.096 11.6 6.1 0.15 11.0 6.1 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Ribosomal_60s PF00428.19 EDO15448.1 - 0.097 13.3 9.7 0.053 14.1 7.0 2.1 1 1 0 1 1 1 0 60s Acidic ribosomal protein GRDP-like PF07173.12 EDO15448.1 - 0.15 12.7 0.3 0.15 12.7 0.3 2.2 1 1 0 2 2 2 0 Glycine-rich domain-containing protein-like BUD22 PF09073.10 EDO15448.1 - 0.49 9.7 22.2 0.51 9.6 22.2 1.1 1 0 0 1 1 1 0 BUD22 PTPRCAP PF15713.5 EDO15448.1 - 0.68 10.2 17.5 1.1 9.5 17.5 1.4 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated Presenilin PF01080.17 EDO15448.1 - 0.72 8.6 5.9 1 8.0 5.9 1.2 1 0 0 1 1 1 0 Presenilin RRN3 PF05327.11 EDO15448.1 - 0.73 8.3 16.1 0.92 8.0 16.1 1.3 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 RNA_pol_Rpc4 PF05132.14 EDO15448.1 - 0.78 10.2 4.2 1.7 9.0 4.2 1.6 1 0 0 1 1 1 0 RNA polymerase III RPC4 SID-1_RNA_chan PF13965.6 EDO15448.1 - 1.3 7.4 3.9 1.5 7.1 3.9 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 CDC45 PF02724.14 EDO15448.1 - 2.4 6.4 17.6 3.3 5.9 17.6 1.3 1 0 0 1 1 1 0 CDC45-like protein Pox_Ag35 PF03286.14 EDO15448.1 - 2.4 7.9 18.4 0.37 10.6 14.5 1.8 2 0 0 2 2 2 0 Pox virus Ag35 surface protein DUF2722 PF10846.8 EDO15448.1 - 8.7 5.2 18.4 13 4.6 18.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) MPM1 PF17234.2 EDO15449.1 - 4.2e-56 189.9 6.9 4.2e-56 189.9 6.9 1.7 2 0 0 2 2 2 1 Mitochondrial peculiar membrane protein 1 RCC1_2 PF13540.6 EDO15450.1 - 2.7e-14 52.5 14.4 4.6e-06 26.3 1.1 5.2 5 0 0 5 5 5 3 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 EDO15450.1 - 2.5e-10 40.8 1.3 0.0025 18.4 0.2 5.3 5 0 0 5 5 5 2 Regulator of chromosome condensation (RCC1) repeat Rad60-SLD PF11976.8 EDO15451.1 - 5.3e-23 80.6 5.5 7.2e-23 80.2 3.6 2.3 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like Arrestin_C PF02752.22 EDO15452.1 - 5.4e-17 62.5 1.2 2.8e-14 53.7 0.1 3.1 3 0 0 3 3 3 2 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 EDO15452.1 - 9.3e-06 25.8 1.2 0.00066 19.8 0.2 3.2 3 0 0 3 3 3 1 Arrestin (or S-antigen), N-terminal domain Exo70 PF03081.15 EDO15453.1 - 1.8e-89 300.4 5.3 6e-89 298.7 1.2 2.2 2 0 0 2 2 2 2 Exo70 exocyst complex subunit Peripla_BP_7 PF18610.1 EDO15453.1 - 0.045 13.9 1.7 0.068 13.3 0.1 2.2 2 0 0 2 2 2 0 Periplasmic binding protein domain RNA_lig_T4_1 PF09511.10 EDO15454.1 - 1.4e-77 260.5 0.1 2.5e-77 259.6 0.1 1.5 1 0 0 1 1 1 1 RNA ligase tRNA_lig_kinase PF08303.11 EDO15454.1 - 3.8e-71 238.6 1.7 7e-71 237.7 0.2 2.2 2 0 0 2 2 2 1 tRNA ligase kinase domain tRNA_lig_CPD PF08302.11 EDO15454.1 - 1.6e-59 201.5 0.4 2.2e-59 201.0 0.4 1.2 1 0 0 1 1 1 1 Fungal tRNA ligase phosphodiesterase domain LigT_PEase PF02834.16 EDO15454.1 - 0.14 12.4 0.0 15 5.9 0.0 2.7 2 0 0 2 2 2 0 LigT like Phosphoesterase NTR2 PF15458.6 EDO15455.1 - 9.6e-37 127.2 31.4 1.1e-36 127.0 31.4 1.0 1 0 0 1 1 1 1 Nineteen complex-related protein 2 GWT1 PF06423.12 EDO15456.1 - 1.7e-35 122.3 7.2 1.7e-35 122.3 7.2 2.3 3 0 0 3 3 3 1 GWT1 Ion_trans_2 PF07885.16 EDO15457.1 - 3.5e-28 97.4 26.9 3.9e-17 62.0 12.9 4.0 4 0 0 4 4 4 2 Ion channel DDDD PF10161.9 EDO15457.1 - 0.094 12.5 0.0 0.32 10.8 0.0 1.9 1 0 0 1 1 1 0 Putative mitochondrial precursor protein Tugs PF17840.1 EDO15457.1 - 0.11 12.7 0.1 0.28 11.4 0.1 1.6 1 0 0 1 1 1 0 Tethering Ubl4a to BAGS domain Lig_chan PF00060.26 EDO15457.1 - 0.46 10.3 15.3 8.2 6.2 2.8 3.7 2 1 0 2 2 2 0 Ligand-gated ion channel Na_H_Exchanger PF00999.21 EDO15458.1 - 5.3e-53 180.2 30.1 7.6e-53 179.7 30.1 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family Chordopox_G3 PF06129.12 EDO15458.1 - 0.66 10.7 5.1 0.16 12.7 0.3 2.5 2 0 0 2 2 2 0 Chordopoxvirus G3 protein DUF2842 PF11003.8 EDO15458.1 - 6.8 7.0 8.1 38 4.6 2.5 3.7 3 0 0 3 3 3 0 Protein of unknown function (DUF2842) Pkinase PF00069.25 EDO15459.1 - 3.8e-65 219.9 0.0 7.7e-65 218.9 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO15459.1 - 3.5e-44 151.1 0.0 6.6e-44 150.1 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDO15459.1 - 1.6e-10 40.8 0.0 1.4e-07 31.1 0.0 2.4 2 0 0 2 2 2 2 Kinase-like APH PF01636.23 EDO15459.1 - 0.16 11.9 0.0 0.3 11.0 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Ribosomal_L21p PF00829.21 EDO15460.1 - 3.9e-11 43.1 0.6 5.2e-11 42.7 0.6 1.2 1 0 0 1 1 1 1 Ribosomal prokaryotic L21 protein ChAPs PF09295.10 EDO15461.1 - 2.6e-41 142.0 7.5 5.1e-29 101.5 3.8 2.3 2 0 0 2 2 2 2 ChAPs (Chs5p-Arf1p-binding proteins) TPR_17 PF13431.6 EDO15461.1 - 0.0076 16.6 0.0 0.026 14.9 0.0 1.9 1 0 0 1 1 1 1 Tetratricopeptide repeat DUF3439 PF11921.8 EDO15461.1 - 0.012 15.6 0.3 0.026 14.5 0.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) TPR_11 PF13414.6 EDO15461.1 - 0.019 14.6 0.0 0.049 13.3 0.0 1.6 1 0 0 1 1 1 0 TPR repeat TPR_9 PF13371.6 EDO15461.1 - 0.054 13.6 0.0 0.096 12.9 0.0 1.3 1 0 0 1 1 1 0 Tetratricopeptide repeat DUF4156 PF13698.6 EDO15461.1 - 0.066 13.6 0.0 0.18 12.1 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4156) TPR_8 PF13181.6 EDO15461.1 - 0.13 12.5 3.9 19 5.8 0.0 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat GCS PF03074.16 EDO15462.1 - 1.1e-146 488.9 0.1 1.5e-146 488.5 0.1 1.2 1 0 0 1 1 1 1 Glutamate-cysteine ligase GTP_EFTU PF00009.27 EDO15463.1 - 4.7e-61 205.7 0.2 1.9e-60 203.8 0.2 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_II PF14492.6 EDO15463.1 - 7.1e-26 90.1 0.0 1.6e-25 89.0 0.0 1.6 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.24 EDO15463.1 - 2.2e-18 66.1 0.0 5.3e-09 36.0 0.0 2.7 2 0 0 2 2 2 2 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 EDO15463.1 - 6.5e-09 36.1 1.8 1.3e-08 35.1 0.3 2.4 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EDO15463.1 - 0.0059 16.7 0.1 0.019 15.0 0.1 1.9 1 0 0 1 1 1 1 50S ribosome-binding GTPase RF3_C PF16658.5 EDO15463.1 - 0.0096 15.7 0.0 0.024 14.4 0.0 1.7 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain SRPRB PF09439.10 EDO15463.1 - 0.012 15.0 0.0 0.035 13.5 0.0 1.8 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Zn_clus PF00172.18 EDO15464.1 - 1.3e-06 28.4 14.1 2.5e-06 27.5 14.1 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PAS PF00989.25 EDO15464.1 - 2e-05 24.5 0.0 4.4e-05 23.5 0.0 1.6 1 0 0 1 1 1 1 PAS fold zf-C2HC5 PF06221.13 EDO15465.1 - 2.4e-22 78.6 5.4 4.2e-22 77.9 5.4 1.4 1 0 0 1 1 1 1 Putative zinc finger motif, C2HC5-type Astro_capsid_N PF03115.14 EDO15465.1 - 2.4 6.7 6.7 0.1 11.2 1.0 1.7 2 0 0 2 2 2 0 Astrovirus capsid protein precursor zf-CCCH PF00642.24 EDO15466.1 - 0.0018 18.1 1.1 0.0018 18.1 1.1 5.4 5 0 0 5 5 5 3 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 EDO15466.1 - 3.8 7.7 28.4 0.12 12.5 2.4 5.3 5 0 0 5 5 5 0 Zinc finger domain Pam16 PF03656.13 EDO15467.1 - 3.3e-49 166.1 0.9 4e-49 165.8 0.9 1.1 1 0 0 1 1 1 1 Pam16 NTP_transferase PF00483.23 EDO15467.1 - 0.022 14.3 0.0 0.024 14.2 0.0 1.1 1 0 0 1 1 1 0 Nucleotidyl transferase PHD PF00628.29 EDO15468.1 - 1.4e-09 37.7 6.7 3.2e-09 36.5 6.7 1.7 1 0 0 1 1 1 1 PHD-finger SET PF00856.28 EDO15468.1 - 1.1e-06 29.2 1.8 1.5e-06 28.7 0.3 2.1 2 1 0 2 2 2 1 SET domain PHD_2 PF13831.6 EDO15468.1 - 0.0014 18.2 1.4 0.003 17.1 1.4 1.5 1 0 0 1 1 1 1 PHD-finger Pkinase PF00069.25 EDO15469.1 - 1.7e-51 175.1 4.8 7.7e-51 173.0 0.1 2.7 3 0 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 EDO15469.1 - 1.4e-26 93.3 0.2 5.1e-25 88.2 0.0 2.9 2 1 0 2 2 2 1 Protein tyrosine kinase Kdo PF06293.14 EDO15469.1 - 0.12 11.8 0.2 0.26 10.6 0.2 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Acyltransferase PF01553.21 EDO15470.1 - 3.2e-32 111.0 0.0 4.8e-32 110.4 0.0 1.2 1 0 0 1 1 1 1 Acyltransferase TMEM164 PF14808.6 EDO15470.1 - 0.0025 17.2 0.7 0.0033 16.8 0.7 1.1 1 0 0 1 1 1 1 TMEM164 family La PF05383.17 EDO15471.1 - 5.8e-22 77.5 0.0 1.3e-21 76.4 0.0 1.6 1 0 0 1 1 1 1 La domain RRM_1 PF00076.22 EDO15471.1 - 9.8e-05 22.1 0.5 0.00049 19.9 0.4 2.2 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Lipocalin_7 PF14651.6 EDO15471.1 - 0.014 15.3 1.3 0.18 11.8 0.4 2.4 2 1 0 2 2 2 0 Lipocalin / cytosolic fatty-acid binding protein family BRAP2 PF07576.12 EDO15471.1 - 0.016 15.4 0.1 0.029 14.6 0.1 1.5 1 0 0 1 1 1 0 BRCA1-associated protein 2 zf-C2H2_4 PF13894.6 EDO15472.1 - 6.3e-08 32.8 20.5 0.00097 19.8 1.4 4.9 4 0 0 4 4 4 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EDO15472.1 - 3.8e-05 23.9 2.5 3.8e-05 23.9 2.5 5.6 5 2 1 6 6 6 1 Zinc-finger double domain zf-C2H2 PF00096.26 EDO15472.1 - 0.00044 20.6 2.2 0.00044 20.6 2.2 4.8 5 0 0 5 5 5 2 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 EDO15472.1 - 0.0023 18.2 10.2 0.017 15.4 0.6 4.0 4 0 0 4 4 4 2 Zinc-finger double-stranded RNA-binding KHA PF11834.8 EDO15472.1 - 0.034 14.2 0.0 0.068 13.3 0.0 1.4 1 0 0 1 1 1 0 KHA, dimerisation domain of potassium ion channel zinc_ribbon_9 PF14369.6 EDO15472.1 - 0.039 14.2 2.0 0.4 11.0 0.2 2.7 2 0 0 2 2 2 0 zinc-ribbon DUF4606 PF15379.6 EDO15472.1 - 0.046 14.0 2.9 0.095 13.0 0.8 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4606) DUF2480 PF10652.9 EDO15472.1 - 0.18 11.7 0.0 0.33 10.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2480) Zn-C2H2_12 PF18112.1 EDO15472.1 - 0.29 11.6 4.5 6 7.4 0.4 3.4 3 0 0 3 3 2 0 Autophagy receptor zinc finger-C2H2 domain zf-AN1 PF01428.16 EDO15472.1 - 0.75 10.0 5.4 6.6 7.0 0.1 3.3 3 0 0 3 3 3 0 AN1-like Zinc finger DZR PF12773.7 EDO15472.1 - 2.4 8.3 7.7 0.95 9.5 1.2 2.6 2 1 0 2 2 2 0 Double zinc ribbon zf-C2H2_6 PF13912.6 EDO15472.1 - 4.3 7.5 13.8 6.4 6.9 1.1 3.9 4 0 0 4 4 4 0 C2H2-type zinc finger zf-Di19 PF05605.12 EDO15472.1 - 5.7 7.3 10.8 5.1 7.5 3.5 3.6 3 1 0 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding ELO PF01151.18 EDO15473.1 - 2.2e-59 201.0 25.4 2.9e-59 200.6 25.4 1.1 1 0 0 1 1 1 1 GNS1/SUR4 family CNH PF00780.22 EDO15474.1 - 1.8e-78 263.9 0.4 4.4e-78 262.7 0.4 1.7 1 0 0 1 1 1 1 CNH domain PH_5 PF15405.6 EDO15474.1 - 1.1e-37 129.2 0.1 1.1e-37 129.2 0.1 3.2 2 1 0 2 2 2 1 Pleckstrin homology domain RhoGEF PF00621.20 EDO15474.1 - 7.8e-31 107.7 0.0 7.8e-31 107.7 0.0 3.4 4 0 0 4 4 4 1 RhoGEF domain DEP PF00610.21 EDO15474.1 - 3.3e-14 52.7 0.0 8.1e-14 51.4 0.0 1.7 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) TFIIA PF03153.13 EDO15474.1 - 0.85 9.5 41.5 1.6 8.6 41.5 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Presenilin PF01080.17 EDO15474.1 - 3 6.5 15.5 5.6 5.6 15.5 1.5 1 0 0 1 1 1 0 Presenilin ALMT PF11744.8 EDO15474.1 - 4 6.2 11.2 10 4.8 11.2 1.8 1 0 0 1 1 1 0 Aluminium activated malate transporter P21-Arc PF04062.14 EDO15475.1 - 1.8e-72 243.0 0.0 2e-72 242.9 0.0 1.0 1 0 0 1 1 1 1 ARP2/3 complex ARPC3 (21 kDa) subunit HSP70 PF00012.20 EDO15476.1 - 4.7e-215 715.3 14.0 5.4e-215 715.1 14.0 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EDO15476.1 - 8.9e-18 64.2 3.4 1.1e-15 57.3 0.7 2.5 2 0 0 2 2 2 2 MreB/Mbl protein BcrAD_BadFG PF01869.20 EDO15476.1 - 0.02 14.4 0.0 1 8.8 0.0 2.7 1 1 0 1 1 1 0 BadF/BadG/BcrA/BcrD ATPase family FGGY_C PF02782.16 EDO15476.1 - 0.079 12.7 0.0 0.15 11.8 0.0 1.4 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, C-terminal domain FtsA PF14450.6 EDO15476.1 - 0.16 12.4 5.1 0.85 10.1 0.4 3.3 2 2 0 2 2 2 0 Cell division protein FtsA DUF45 PF01863.17 EDO15476.1 - 1.8 8.5 8.1 1.5 8.8 6.4 1.7 2 0 0 2 2 2 0 Protein of unknown function DUF45 F-box PF00646.33 EDO15477.1 - 0.00045 20.0 4.7 0.0013 18.6 4.7 1.9 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EDO15477.1 - 0.085 12.8 4.9 0.084 12.8 1.8 2.5 2 0 0 2 2 2 0 F-box-like Arrestin_C PF02752.22 EDO15478.1 - 2.7e-19 70.0 0.4 1.6e-18 67.5 0.2 2.3 2 0 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 EDO15478.1 - 5.1e-07 29.9 0.0 2.2e-05 24.5 0.0 2.5 2 1 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain Ycf15 PF10705.9 EDO15478.1 - 0.023 14.9 0.3 0.39 10.9 0.0 2.8 3 0 0 3 3 3 0 Chloroplast protein precursor Ycf15 putative zf-C2H2 PF00096.26 EDO15479.1 - 3.7e-08 33.4 15.2 0.00011 22.4 0.5 3.7 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EDO15479.1 - 5.4e-06 26.6 1.1 5.4e-06 26.6 1.1 3.4 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 EDO15479.1 - 7e-06 26.4 10.2 0.0041 17.8 0.5 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_3rep PF18868.1 EDO15479.1 - 0.2 12.4 5.0 0.51 11.0 5.0 1.8 1 0 0 1 1 1 0 Zinc finger C2H2-type, 3 repeats zf-C2H2_6 PF13912.6 EDO15479.1 - 0.27 11.3 11.2 1.2 9.2 0.2 3.0 2 1 0 2 2 2 0 C2H2-type zinc finger Menin PF05053.13 EDO15479.1 - 0.33 9.2 3.9 0.54 8.6 3.9 1.2 1 0 0 1 1 1 0 Menin Pih1_fungal_CS PF18482.1 EDO15479.1 - 1.2 9.7 8.1 12 6.5 3.6 3.7 2 1 1 3 3 3 0 Fungal Pih1 CS domain zf-C2H2_jaz PF12171.8 EDO15479.1 - 2.1 8.7 14.7 1.9 8.9 3.3 3.3 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding zf-C2HC_2 PF13913.6 EDO15479.1 - 2.7 8.0 4.5 26 4.9 0.7 2.6 2 0 0 2 2 2 0 zinc-finger of a C2HC-type Ribosomal_S8 PF00410.19 EDO15480.1 - 7.6e-24 84.1 0.2 1.3e-23 83.3 0.2 1.4 1 1 0 1 1 1 1 Ribosomal protein S8 Spt4 PF06093.13 EDO15481.1 - 4.4e-29 100.4 0.4 5.1e-29 100.2 0.4 1.1 1 0 0 1 1 1 1 Spt4/RpoE2 zinc finger TackOD1 PF18551.1 EDO15481.1 - 0.1 12.3 1.0 0.13 11.9 1.0 1.2 1 0 0 1 1 1 0 Thaumarchaeal output domain 1 60KD_IMP PF02096.20 EDO15482.1 - 6.1e-11 42.5 8.3 1.4e-10 41.3 8.3 1.6 1 1 0 1 1 1 1 60Kd inner membrane protein F-box-like_2 PF13013.6 EDO15482.1 - 0.01 15.8 0.6 0.017 15.1 0.6 1.3 1 0 0 1 1 1 0 F-box-like domain Bmt2 PF11968.8 EDO15482.1 - 0.015 15.1 0.3 0.023 14.5 0.3 1.2 1 0 0 1 1 1 0 25S rRNA (adenine(2142)-N(1))-methyltransferase, Bmt2 FA_hydroxylase PF04116.13 EDO15483.1 - 5.3e-26 91.5 18.7 5.3e-26 91.5 18.7 2.2 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily Metallophos PF00149.28 EDO15484.1 - 2e-16 61.1 0.1 3.9e-16 60.2 0.1 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EDO15484.1 - 3e-05 24.3 0.0 0.00052 20.3 0.0 2.2 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Bromodomain PF00439.25 EDO15485.1 - 1.9e-26 91.9 6.3 5.6e-14 52.0 0.5 2.9 2 0 0 2 2 2 2 Bromodomain BAH PF01426.18 EDO15485.1 - 9e-23 80.4 0.8 2.8e-22 78.8 0.2 2.3 3 0 0 3 3 3 1 BAH domain TAL_FSA PF00923.19 EDO15486.1 - 3.4e-94 315.4 0.1 3.9e-94 315.2 0.1 1.0 1 0 0 1 1 1 1 Transaldolase/Fructose-6-phosphate aldolase DUF3887 PF13026.6 EDO15486.1 - 0.047 14.5 2.2 0.14 13.0 0.1 2.8 3 1 0 3 3 3 0 Protein of unknown function (DUF3887) DUF2439 PF10382.9 EDO15487.1 - 3.2e-23 81.9 2.5 6.8e-23 80.8 2.5 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2439) Fungal_trans PF04082.18 EDO15489.1 - 5.6e-12 45.3 2.6 1.2e-11 44.2 2.6 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDO15489.1 - 4.5e-08 33.1 9.0 9.6e-08 32.0 9.0 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Ferric_reduct PF01794.19 EDO15490.1 - 1.1e-21 77.2 6.6 1.1e-21 77.2 6.6 2.1 2 0 0 2 2 2 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.12 EDO15490.1 - 1.2e-13 51.5 0.0 1.9e-13 50.8 0.0 1.3 1 0 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 EDO15490.1 - 1e-07 32.0 0.7 3.1e-07 30.5 0.1 2.0 2 0 0 2 2 2 1 FAD-binding domain NAD_binding_1 PF00175.21 EDO15490.1 - 0.011 16.3 0.0 0.3 11.7 0.0 2.3 2 0 0 2 2 2 0 Oxidoreductase NAD-binding domain Ran-binding PF05508.11 EDO15492.1 - 1.6e-101 339.4 8.2 1.6e-101 339.4 8.2 1.3 2 0 0 2 2 2 1 RanGTP-binding protein CHASE3 PF05227.13 EDO15492.1 - 0.065 13.2 1.1 0.11 12.4 1.1 1.3 1 0 0 1 1 1 0 CHASE3 domain SAWADEE PF16719.5 EDO15492.1 - 0.069 13.2 0.2 6.7 6.7 0.0 2.4 2 0 0 2 2 2 0 SAWADEE domain DUF1640 PF07798.11 EDO15492.1 - 0.7 9.9 11.0 1.3 9.0 7.2 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1640) Noelin-1 PF12308.8 EDO15492.1 - 2.7 8.0 5.3 3.1 7.9 1.6 2.7 2 0 0 2 2 2 0 Neurogenesis glycoprotein Copper-fist PF00649.18 EDO15493.1 - 9.1e-21 73.1 1.3 9.1e-21 73.1 1.3 2.4 1 1 1 2 2 2 1 Copper fist DNA binding domain Menin PF05053.13 EDO15493.1 - 2.4 6.4 12.3 3.3 6.0 12.3 1.2 1 0 0 1 1 1 0 Menin DUF3461 PF11944.8 EDO15494.1 - 0.3 11.2 8.7 0.1 12.8 1.1 2.8 2 1 0 3 3 3 0 Protein of unknown function (DUF3461) LMBR1 PF04791.16 EDO15494.1 - 0.7 8.7 5.8 0.92 8.3 5.8 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein ICL PF00463.21 EDO15495.1 - 6.5e-158 526.5 0.1 7.3e-158 526.3 0.1 1.0 1 0 0 1 1 1 1 Isocitrate lyase family PEP_mutase PF13714.6 EDO15495.1 - 2.4e-07 30.5 0.0 3.7e-07 29.9 0.0 1.2 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase Cep57_CLD_2 PF14197.6 EDO15495.1 - 0.042 13.9 0.3 0.1 12.7 0.3 1.6 1 0 0 1 1 1 0 Centrosome localisation domain of PPC89 RNA_pol_Rpb1_6 PF04992.14 EDO15495.1 - 0.12 12.2 0.9 0.33 10.8 0.9 1.8 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 6 SGT1 PF07093.11 EDO15496.1 - 0.08 11.4 17.0 0.11 10.9 17.0 1.1 1 0 0 1 1 1 0 SGT1 protein Astro_capsid_p PF12226.8 EDO15496.1 - 0.27 10.3 22.9 0.53 9.4 22.9 1.5 1 0 0 1 1 1 0 Turkey astrovirus capsid protein RRN3 PF05327.11 EDO15496.1 - 0.34 9.4 15.9 0.7 8.4 15.9 1.4 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 DNA_pol_phi PF04931.13 EDO15496.1 - 0.58 8.2 37.0 0.89 7.6 37.0 1.2 1 0 0 1 1 1 0 DNA polymerase phi Nop53 PF07767.11 EDO15496.1 - 1.4 8.2 19.6 2 7.7 19.6 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) DUF2457 PF10446.9 EDO15496.1 - 1.9 7.6 40.1 1.8 7.6 0.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2457) CobT PF06213.12 EDO15496.1 - 3 7.2 23.5 6.1 6.1 23.5 1.5 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT TRAP_alpha PF03896.16 EDO15496.1 - 6.7 5.8 15.4 12 5.0 15.4 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit AAA_33 PF13671.6 EDO15497.1 - 1.1e-06 28.9 0.0 0.0022 18.1 0.0 2.3 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.6 EDO15497.1 - 4e-05 24.2 0.0 9.6e-05 22.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 EDO15497.1 - 0.00018 21.5 0.0 0.00057 19.9 0.0 1.8 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EDO15497.1 - 0.00066 20.1 0.0 0.0012 19.2 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EDO15497.1 - 0.00089 19.5 0.0 0.002 18.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 EDO15497.1 - 0.0009 19.6 0.0 0.0018 18.6 0.0 1.5 1 0 0 1 1 1 1 RNA helicase AAA PF00004.29 EDO15497.1 - 0.0012 19.3 0.0 0.0028 18.1 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ABC_tran PF00005.27 EDO15497.1 - 0.0014 19.2 0.0 0.0028 18.2 0.0 1.5 1 0 0 1 1 1 1 ABC transporter AAA_28 PF13521.6 EDO15497.1 - 0.0032 17.7 0.0 0.0063 16.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.6 EDO15497.1 - 0.0033 17.8 0.0 0.031 14.7 0.0 2.2 2 0 0 2 2 2 1 AAA domain PRK PF00485.18 EDO15497.1 - 0.0037 17.0 0.0 0.58 9.9 0.0 2.5 2 1 0 2 2 2 1 Phosphoribulokinase / Uridine kinase family MMR_HSR1 PF01926.23 EDO15497.1 - 0.0073 16.4 0.0 0.018 15.1 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase NB-ARC PF00931.22 EDO15497.1 - 0.0092 15.2 0.0 0.03 13.5 0.0 1.8 2 0 0 2 2 2 1 NB-ARC domain Mg_chelatase PF01078.21 EDO15497.1 - 0.012 15.0 0.0 0.02 14.3 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_24 PF13479.6 EDO15497.1 - 0.019 14.7 0.0 0.062 13.0 0.0 1.8 2 0 0 2 2 2 0 AAA domain ADK PF00406.22 EDO15497.1 - 0.025 14.7 0.0 1.1 9.4 0.0 2.4 2 1 0 2 2 2 0 Adenylate kinase Rad17 PF03215.15 EDO15497.1 - 0.026 14.5 0.0 0.052 13.5 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain APS_kinase PF01583.20 EDO15497.1 - 0.032 14.1 0.0 0.057 13.3 0.0 1.4 1 0 0 1 1 1 0 Adenylylsulphate kinase KTI12 PF08433.10 EDO15497.1 - 0.034 13.6 0.0 0.059 12.8 0.0 1.3 1 0 0 1 1 1 0 Chromatin associated protein KTI12 Cytidylate_kin PF02224.18 EDO15497.1 - 0.034 13.9 0.0 0.062 13.0 0.0 1.4 1 0 0 1 1 1 0 Cytidylate kinase NTPase_1 PF03266.15 EDO15497.1 - 0.034 14.0 0.0 0.069 13.1 0.0 1.5 1 0 0 1 1 1 0 NTPase ATP_bind_1 PF03029.17 EDO15497.1 - 0.043 13.6 0.0 0.36 10.6 0.0 2.3 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein 6PF2K PF01591.18 EDO15497.1 - 0.047 13.0 0.0 0.16 11.2 0.0 1.8 2 0 0 2 2 2 0 6-phosphofructo-2-kinase cobW PF02492.19 EDO15497.1 - 0.052 13.1 0.0 0.25 10.9 0.0 2.0 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain RsgA_GTPase PF03193.16 EDO15497.1 - 0.055 13.4 0.0 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase AAA_23 PF13476.6 EDO15497.1 - 0.058 13.9 0.0 0.11 13.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 EDO15497.1 - 0.064 13.0 0.0 0.14 12.0 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Zeta_toxin PF06414.12 EDO15497.1 - 0.068 12.4 0.0 0.12 11.6 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin ATPase_2 PF01637.18 EDO15497.1 - 0.069 13.1 0.0 0.14 12.1 0.0 1.5 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea Guanylate_kin PF00625.21 EDO15497.1 - 0.073 12.8 0.0 0.16 11.6 0.0 1.6 2 0 0 2 2 1 0 Guanylate kinase AAA_7 PF12775.7 EDO15497.1 - 0.08 12.4 0.0 0.14 11.7 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region T2SSE PF00437.20 EDO15497.1 - 0.086 11.9 0.0 0.14 11.2 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein TniB PF05621.11 EDO15497.1 - 0.16 11.4 0.0 0.27 10.6 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein Thymidylate_kin PF02223.17 EDO15497.1 - 0.17 11.5 0.0 0.34 10.6 0.0 1.5 1 0 0 1 1 1 0 Thymidylate kinase AAA_11 PF13086.6 EDO15497.1 - 0.18 11.5 0.0 0.31 10.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain Ploopntkinase3 PF18751.1 EDO15497.1 - 0.21 11.5 0.0 0.51 10.2 0.0 1.6 2 0 0 2 2 1 0 P-loop Nucleotide Kinase3 AAA_30 PF13604.6 EDO15497.1 - 0.23 11.1 0.0 0.39 10.4 0.0 1.2 1 0 0 1 1 1 0 AAA domain ETF PF01012.21 EDO15498.1 - 9e-39 133.2 0.0 1.7e-38 132.3 0.0 1.5 1 0 0 1 1 1 1 Electron transfer flavoprotein domain ETF_alpha PF00766.19 EDO15498.1 - 3.4e-32 110.3 0.1 6.3e-32 109.5 0.1 1.5 1 0 0 1 1 1 1 Electron transfer flavoprotein FAD-binding domain Sulfate_transp PF00916.20 EDO15499.1 - 1.1e-92 310.8 21.3 1.4e-92 310.4 21.3 1.1 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 EDO15499.1 - 6.5e-19 67.7 0.4 2.4e-18 65.8 0.1 2.1 2 0 0 2 2 2 1 STAS domain MFS_MOT1 PF16983.5 EDO15499.1 - 0.00025 21.4 4.4 0.00025 21.4 4.4 3.1 3 1 0 3 3 3 1 Molybdate transporter of MFS superfamily DUF1072 PF06380.11 EDO15499.1 - 0.15 12.0 9.0 0.035 14.0 1.7 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1072) BAF1_ABF1 PF04684.13 EDO15500.1 - 2.6e-195 650.7 67.8 5.3e-97 326.2 25.3 3.0 1 1 2 3 3 3 3 BAF1 / ABF1 chromatin reorganising factor DBD_Tnp_Mut PF03108.15 EDO15500.1 - 0.01 15.8 0.3 0.022 14.8 0.3 1.5 1 0 0 1 1 1 0 MuDR family transposase T2SSM PF04612.12 EDO15500.1 - 1.3 9.0 4.3 20 5.2 0.3 2.4 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein M mRNA_stabil PF13929.6 EDO15501.1 - 1.9e-95 319.2 17.6 4.3e-95 318.0 17.6 1.6 1 0 0 1 1 1 1 mRNA stabilisation RsfS PF02410.15 EDO15501.1 - 5.1e-21 74.9 1.7 4.2e-20 72.0 0.1 2.9 2 1 1 3 3 3 1 Ribosomal silencing factor during starvation Sterile PF03015.19 EDO15501.1 - 0.22 11.8 2.0 1.2 9.4 0.4 2.8 2 0 0 2 2 2 0 Male sterility protein Corazonin PF17308.2 EDO15501.1 - 0.75 10.2 7.9 0.12 12.8 1.4 2.7 2 0 0 2 2 2 0 Pro-corazonin KTI12 PF08433.10 EDO15502.1 - 2e-97 325.9 2.0 2.2e-97 325.8 2.0 1.0 1 0 0 1 1 1 1 Chromatin associated protein KTI12 APS_kinase PF01583.20 EDO15502.1 - 0.0005 20.0 0.0 0.0014 18.6 0.0 1.6 1 1 0 1 1 1 1 Adenylylsulphate kinase AAA_18 PF13238.6 EDO15502.1 - 0.00096 19.7 0.6 0.0026 18.3 0.1 2.1 2 2 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EDO15502.1 - 0.0012 19.0 0.0 0.0026 17.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EDO15502.1 - 0.013 15.8 0.0 0.42 10.9 0.0 2.8 3 0 0 3 3 3 0 AAA domain AAA PF00004.29 EDO15502.1 - 0.082 13.3 0.0 0.26 11.7 0.0 1.9 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 EDO15502.1 - 0.11 13.0 0.2 0.34 11.3 0.2 2.1 1 1 0 1 1 1 0 RNA helicase Mg_chelatase PF01078.21 EDO15502.1 - 0.15 11.5 0.0 0.3 10.4 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI MMR_HSR1 PF01926.23 EDO15503.1 - 3e-13 49.8 0.6 6.7e-13 48.7 0.0 1.9 2 1 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EDO15503.1 - 0.00011 22.2 6.3 0.0015 18.5 6.3 2.3 1 1 0 1 1 1 1 RsgA GTPase GTP_EFTU PF00009.27 EDO15503.1 - 0.00069 19.2 2.6 0.0027 17.3 0.1 2.2 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain Septin PF00735.18 EDO15503.1 - 0.0022 17.3 1.0 0.0038 16.5 0.0 1.8 2 0 0 2 2 2 1 Septin FeoB_N PF02421.18 EDO15503.1 - 0.0073 15.8 0.2 0.022 14.3 0.2 1.9 1 1 0 1 1 1 1 Ferrous iron transport protein B AAA_29 PF13555.6 EDO15503.1 - 0.023 14.4 0.1 0.096 12.4 0.0 1.9 2 0 0 2 2 2 0 P-loop containing region of AAA domain MeaB PF03308.16 EDO15503.1 - 0.057 12.4 0.2 3.3 6.6 0.1 2.2 1 1 1 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_18 PF13238.6 EDO15503.1 - 0.083 13.4 1.6 0.18 12.3 0.3 2.2 2 0 0 2 2 2 0 AAA domain Dynamin_N PF00350.23 EDO15503.1 - 0.47 10.5 4.0 11 6.0 0.1 3.0 2 1 1 3 3 3 0 Dynamin family SOR_SNZ PF01680.17 EDO15504.1 - 9.1e-105 349.0 4.6 1.2e-104 348.6 4.6 1.1 1 0 0 1 1 1 1 SOR/SNZ family ThiG PF05690.14 EDO15504.1 - 6.1e-10 38.8 1.2 1.2e-07 31.3 0.0 2.4 2 0 0 2 2 2 2 Thiazole biosynthesis protein ThiG Dus PF01207.17 EDO15504.1 - 0.00052 19.2 0.1 0.37 9.8 0.0 2.6 2 1 0 2 2 2 2 Dihydrouridine synthase (Dus) TMP-TENI PF02581.17 EDO15504.1 - 0.0018 17.7 0.3 0.13 11.6 0.0 2.8 3 0 0 3 3 3 1 Thiamine monophosphate synthase His_biosynth PF00977.21 EDO15504.1 - 0.0044 16.5 0.2 0.049 13.1 0.0 2.2 2 0 0 2 2 2 1 Histidine biosynthesis protein TetR_C_27 PF17935.1 EDO15504.1 - 0.0085 16.1 0.0 0.056 13.5 0.0 2.2 2 0 0 2 2 2 1 Tetracyclin repressor-like, C-terminal domain IGPS PF00218.21 EDO15504.1 - 0.023 13.9 0.1 1 8.5 0.0 2.5 2 1 0 2 2 2 0 Indole-3-glycerol phosphate synthase NanE PF04131.14 EDO15504.1 - 0.024 13.8 0.7 0.32 10.2 0.0 2.4 1 1 0 2 2 2 0 Putative N-acetylmannosamine-6-phosphate epimerase NMO PF03060.15 EDO15504.1 - 0.024 14.0 2.7 0.28 10.5 0.1 2.3 2 0 0 2 2 2 0 Nitronate monooxygenase 1-cysPrx_C PF10417.9 EDO15504.1 - 0.082 12.8 0.2 3.2 7.7 0.0 2.4 2 0 0 2 2 2 0 C-terminal domain of 1-Cys peroxiredoxin Med10 PF09748.9 EDO15504.1 - 0.13 12.3 0.1 0.35 10.8 0.0 1.8 2 0 0 2 2 2 0 Transcription factor subunit Med10 of Mediator complex SNO PF01174.19 EDO15505.1 - 7.9e-73 244.3 0.0 3e-38 131.6 0.0 2.0 2 0 0 2 2 2 2 SNO glutamine amidotransferase family GATase_3 PF07685.14 EDO15505.1 - 4.3e-07 29.7 0.0 6.3e-07 29.2 0.0 1.3 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain Peptidase_S51 PF03575.17 EDO15505.1 - 0.0059 16.3 0.0 0.011 15.4 0.0 1.5 1 1 0 1 1 1 1 Peptidase family S51 DJ-1_PfpI PF01965.24 EDO15505.1 - 0.021 14.6 0.0 0.033 14.0 0.0 1.3 1 0 0 1 1 1 0 DJ-1/PfpI family Xylo_C PF12529.8 EDO15506.1 - 0.0003 20.4 0.2 0.00056 19.6 0.2 1.4 1 0 0 1 1 1 1 Xylosyltransferase C terminal DUF4090 PF13319.6 EDO15506.1 - 0.043 14.1 0.4 0.36 11.1 0.0 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF4090) Drc1-Sld2 PF11719.8 EDO15507.1 - 7.2e-65 220.3 22.3 6.8e-64 217.1 22.3 1.9 1 1 0 1 1 1 1 DNA replication and checkpoint protein RNA_pol_Rpb8 PF03870.15 EDO15507.1 - 0.055 13.7 1.6 0.085 13.0 0.8 1.7 2 0 0 2 2 2 0 RNA polymerase Rpb8 UTP15_C PF09384.10 EDO15508.1 - 1.6e-39 134.9 0.1 2.6e-39 134.2 0.1 1.3 1 0 0 1 1 1 1 UTP15 C terminal WD40 PF00400.32 EDO15508.1 - 5.5e-15 55.5 2.5 0.031 15.1 0.0 6.8 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDO15508.1 - 5.8e-05 23.3 0.0 0.022 15.1 0.0 4.0 3 2 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EDO15509.1 - 1.1e-13 51.4 25.0 0.76 10.8 0.3 9.7 10 0 0 10 10 10 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDO15509.1 - 1.1e-09 38.5 3.5 0.0099 16.2 0.0 7.2 4 3 4 9 9 9 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EDO15509.1 - 2.9e-07 30.6 2.3 0.023 14.6 0.2 5.0 4 2 2 6 6 6 2 Eukaryotic translation initiation factor eIF2A GluRS_N PF18466.1 EDO15509.1 - 0.012 16.0 0.2 6.1 7.3 0.1 3.1 2 0 0 2 2 2 0 Glutamate--tRNA ligase N-terminal domain WD40_like PF17005.5 EDO15509.1 - 0.034 13.5 3.8 0.42 9.9 0.1 3.1 3 1 0 3 3 3 0 WD40-like domain RAB3GAP2_N PF14655.6 EDO15509.1 - 0.072 12.3 0.0 0.16 11.2 0.0 1.6 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus NAD_binding_10 PF13460.6 EDO15510.1 - 6.1e-44 150.1 0.0 7e-44 149.9 0.0 1.0 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 EDO15510.1 - 7.3e-07 29.0 0.0 1.9e-06 27.6 0.0 1.6 1 1 0 1 1 1 1 NmrA-like family Semialdhyde_dh PF01118.24 EDO15510.1 - 3.9e-05 24.1 0.0 5.7e-05 23.5 0.0 1.2 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain DapB_N PF01113.20 EDO15510.1 - 5.9e-05 23.2 0.0 0.00011 22.3 0.0 1.5 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus Ldh_1_N PF00056.23 EDO15510.1 - 0.00026 21.1 0.1 0.00036 20.6 0.1 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain 3Beta_HSD PF01073.19 EDO15510.1 - 0.00042 19.4 0.2 0.00061 18.9 0.2 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 EDO15510.1 - 0.028 13.9 0.0 0.047 13.2 0.0 1.4 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family GFO_IDH_MocA PF01408.22 EDO15510.1 - 0.053 14.3 0.0 0.081 13.8 0.0 1.3 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold F420_oxidored PF03807.17 EDO15510.1 - 0.062 13.9 0.2 0.1 13.2 0.2 1.3 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Peptidase_M41 PF01434.18 EDO15511.1 - 2.2e-68 229.9 1.1 3e-68 229.4 0.0 1.8 2 0 0 2 2 2 1 Peptidase family M41 AAA PF00004.29 EDO15511.1 - 1.2e-42 145.4 0.0 4.3e-42 143.7 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EDO15511.1 - 4.1e-12 45.7 0.1 1.2e-11 44.2 0.1 1.8 1 0 0 1 1 1 1 AAA+ lid domain FtsH_ext PF06480.15 EDO15511.1 - 5.1e-06 26.8 0.4 5.1e-06 26.8 0.4 3.0 2 2 0 2 2 1 1 FtsH Extracellular AAA_2 PF07724.14 EDO15511.1 - 0.0006 20.0 0.1 0.0045 17.1 0.0 2.5 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_17 PF13207.6 EDO15511.1 - 0.0011 19.4 1.3 0.0067 16.9 0.0 2.7 2 0 0 2 2 2 1 AAA domain RuvB_N PF05496.12 EDO15511.1 - 0.0017 18.1 0.0 0.0036 17.1 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 EDO15511.1 - 0.0022 18.0 0.1 0.017 15.1 0.0 2.5 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EDO15511.1 - 0.0024 18.3 0.3 0.02 15.3 0.1 2.6 2 1 0 2 2 2 1 AAA ATPase domain TIP49 PF06068.13 EDO15511.1 - 0.0032 16.7 0.0 0.0075 15.5 0.0 1.6 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_22 PF13401.6 EDO15511.1 - 0.016 15.4 0.1 0.72 10.1 0.1 2.8 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 EDO15511.1 - 0.033 13.9 0.0 0.079 12.7 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_33 PF13671.6 EDO15511.1 - 0.065 13.4 0.1 0.26 11.4 0.0 2.2 2 0 0 2 2 1 0 AAA domain HCO3_cotransp PF00955.21 EDO15511.1 - 0.69 8.7 3.0 1.3 7.7 3.0 1.3 1 0 0 1 1 1 0 HCO3- transporter family AAA_18 PF13238.6 EDO15511.1 - 1.1 9.8 0.0 1.1 9.8 0.0 3.6 2 1 1 3 3 2 0 AAA domain Presenilin PF01080.17 EDO15511.1 - 5 5.8 12.2 8.4 5.0 12.2 1.3 1 0 0 1 1 1 0 Presenilin MFS_1 PF07690.16 EDO15512.1 - 1.5e-40 139.2 23.0 4.9e-40 137.5 23.0 1.7 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EDO15512.1 - 3.1e-15 56.0 10.8 3.1e-15 56.0 10.8 2.1 2 1 0 2 2 2 1 Sugar (and other) transporter Arf PF00025.21 EDO15513.1 - 3.2e-57 192.8 0.1 3.6e-57 192.6 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EDO15513.1 - 6.4e-10 39.3 0.1 8e-10 39.0 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EDO15513.1 - 1.4e-06 28.0 0.0 1.6e-06 27.8 0.0 1.0 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 EDO15513.1 - 3.5e-06 26.4 0.0 5.7e-06 25.7 0.0 1.3 1 1 0 1 1 1 1 G-protein alpha subunit Gtr1_RagA PF04670.12 EDO15513.1 - 4.2e-06 26.3 0.0 4.8e-06 26.1 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 EDO15513.1 - 0.00076 19.0 0.0 0.00084 18.8 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 EDO15513.1 - 0.0012 18.4 0.0 0.0014 18.2 0.0 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain MeaB PF03308.16 EDO15513.1 - 0.021 13.8 0.3 0.097 11.6 0.3 1.8 1 1 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB 2-Hacid_dh_C PF02826.19 EDO15514.1 - 4e-37 127.3 0.0 6.4e-37 126.6 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.12 EDO15514.1 - 0.0099 15.5 0.0 0.017 14.7 0.0 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain 2-Hacid_dh PF00389.30 EDO15514.1 - 0.057 13.1 0.0 0.072 12.7 0.0 1.2 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain F420_oxidored PF03807.17 EDO15514.1 - 0.13 12.9 0.0 0.3 11.7 0.0 1.6 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Fungal_TACC PF12709.7 EDO15515.1 - 1.5e-32 111.9 14.7 1.5e-32 111.9 14.7 8.9 2 1 5 8 8 8 1 Fungal Transforming acidic coiled-coil (TACC) proteins EzrA PF06160.12 EDO15515.1 - 0.00046 18.5 23.0 0.00046 18.5 23.0 5.1 1 1 4 5 5 5 3 Septation ring formation regulator, EzrA Golgin_A5 PF09787.9 EDO15515.1 - 0.0039 16.7 30.5 0.0039 16.7 30.5 5.7 1 1 5 6 6 6 1 Golgin subfamily A member 5 SRF-TF PF00319.18 EDO15515.1 - 0.31 10.6 0.0 0.31 10.6 0.0 2.3 3 0 0 3 3 3 0 SRF-type transcription factor (DNA-binding and dimerisation domain) Filament PF00038.21 EDO15515.1 - 0.39 10.3 99.6 0.017 14.7 44.5 3.5 1 1 2 3 3 3 0 Intermediate filament protein CALCOCO1 PF07888.11 EDO15515.1 - 2.1 7.1 93.4 0.015 14.2 33.2 3.4 2 1 0 4 4 4 0 Calcium binding and coiled-coil domain (CALCOCO1) like RhoGAP PF00620.27 EDO15516.1 - 8e-38 129.6 0.2 8e-38 129.6 0.2 2.3 3 0 0 3 3 3 1 RhoGAP domain PH PF00169.29 EDO15516.1 - 6.2e-10 39.5 0.4 1.7e-09 38.1 0.2 1.9 2 0 0 2 2 2 1 PH domain PX PF00787.24 EDO15516.1 - 0.00054 19.9 0.0 0.0015 18.5 0.0 1.8 1 0 0 1 1 1 1 PX domain Cnn_1N PF07989.11 EDO15516.1 - 0.0016 18.5 1.1 0.0083 16.3 1.1 2.3 1 0 0 1 1 1 1 Centrosomin N-terminal motif 1 Shugoshin_N PF07558.11 EDO15516.1 - 0.027 14.3 1.9 0.057 13.3 0.4 2.4 2 0 0 2 2 2 0 Shugoshin N-terminal coiled-coil region Radical_SAM PF04055.21 EDO15517.1 - 6.6e-16 59.1 0.0 9.5e-16 58.6 0.0 1.3 1 0 0 1 1 1 1 Radical SAM superfamily Spore_GerAC PF05504.11 EDO15517.1 - 0.0091 16.2 0.0 0.012 15.8 0.0 1.3 1 0 0 1 1 1 1 Spore germination B3/ GerAC like, C-terminal Hist_deacetyl PF00850.19 EDO15518.1 - 9e-52 176.4 0.1 1.6e-51 175.6 0.1 1.4 1 0 0 1 1 1 1 Histone deacetylase domain DFF40 PF09230.10 EDO15518.1 - 0.0011 18.7 0.1 0.0066 16.1 0.0 2.1 2 0 0 2 2 2 1 DNA fragmentation factor 40 kDa Peptidase_C14 PF00656.22 EDO15519.1 - 3.5e-60 204.0 0.1 5e-60 203.5 0.1 1.2 1 0 0 1 1 1 1 Caspase domain Tox-REase-9 PF15650.6 EDO15520.1 - 0.042 14.1 0.7 0.042 14.1 0.7 3.7 3 1 0 3 3 3 0 Restriction endonuclease fold toxin 9 NUDIX PF00293.28 EDO15521.1 - 3.3e-28 98.4 0.0 5.2e-28 97.7 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain IGPD PF00475.18 EDO15522.1 - 5.2e-61 205.2 0.2 9.6e-61 204.3 0.2 1.4 2 0 0 2 2 2 1 Imidazoleglycerol-phosphate dehydratase APG6 PF04111.12 EDO15523.1 - 5.5e-65 218.7 0.2 1.5e-64 217.3 0.2 1.7 1 0 0 1 1 1 1 Apg6 BARA domain APG6_N PF17675.1 EDO15523.1 - 3.2e-27 95.6 20.7 6e-27 94.8 20.7 1.5 1 0 0 1 1 1 1 Apg6 coiled-coil region TPD52 PF04201.15 EDO15523.1 - 0.021 14.5 7.6 0.054 13.1 7.6 1.7 1 0 0 1 1 1 0 Tumour protein D52 family Radial_spoke_3 PF06098.11 EDO15523.1 - 1.1 8.5 11.3 1.7 7.9 0.1 2.2 1 1 1 2 2 2 0 Radial spoke protein 3 DUF4094 PF13334.6 EDO15523.1 - 2.4 8.6 5.3 2.4 8.7 2.9 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4094) MMR_HSR1 PF01926.23 EDO15524.1 - 3.7e-09 36.7 0.0 1.2e-08 35.1 0.0 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EDO15524.1 - 0.00011 22.1 0.0 0.0002 21.3 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase FeoB_N PF02421.18 EDO15524.1 - 0.0012 18.4 0.7 0.014 14.9 0.2 2.5 3 0 0 3 3 3 1 Ferrous iron transport protein B Med26_C PF15693.5 EDO15524.1 - 0.022 14.9 0.2 3.7 7.6 0.0 2.3 2 0 0 2 2 2 0 Mediator complex subunit 26 C-terminal GTP_EFTU PF00009.27 EDO15524.1 - 0.035 13.6 0.0 4.5 6.8 0.0 2.4 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain RNA_helicase PF00910.22 EDO15524.1 - 0.039 14.3 0.0 0.12 12.8 0.0 1.9 1 0 0 1 1 1 0 RNA helicase Ploopntkinase3 PF18751.1 EDO15524.1 - 0.04 13.8 0.0 0.088 12.7 0.0 1.5 1 0 0 1 1 1 0 P-loop Nucleotide Kinase3 Noc2 PF03715.13 EDO15525.1 - 4.9e-94 314.9 1.5 1.4e-93 313.5 1.5 1.8 1 0 0 1 1 1 1 Noc2p family Mei5 PF10376.9 EDO15526.1 - 6.8e-48 163.3 15.3 8.6e-48 162.9 15.3 1.0 1 0 0 1 1 1 1 Double-strand recombination repair protein CAMSAP_CC1 PF17095.5 EDO15526.1 - 0.0038 17.1 1.6 0.014 15.2 1.6 2.0 1 0 0 1 1 1 1 Spectrin-binding region of Ca2+-Calmodulin Syntaxin-6_N PF09177.11 EDO15526.1 - 0.14 12.7 10.6 0.061 13.9 4.6 2.6 1 1 1 2 2 2 0 Syntaxin 6, N-terminal Peptidase_M15_2 PF05951.13 EDO15526.1 - 0.3 10.7 2.3 0.73 9.5 0.1 2.1 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF882) CHASE9 PF17153.4 EDO15526.1 - 0.48 10.6 11.1 0.067 13.3 1.3 2.3 2 0 0 2 2 2 0 Periplasmic sensor domain, extracellular Histidinol_dh PF00815.20 EDO15526.1 - 4.6 6.1 5.0 2.6 7.0 0.1 2.1 1 1 0 2 2 2 0 Histidinol dehydrogenase DUF3837 PF12939.7 EDO15526.1 - 7.7 7.0 10.2 0.16 12.4 1.0 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF3837) RNA_pol_Rpb2_6 PF00562.28 EDO15527.1 - 1.7e-123 412.6 0.1 1.7e-123 412.6 0.1 1.5 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 EDO15527.1 - 1.2e-61 207.8 0.9 1.7e-61 207.3 0.9 1.3 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_2 PF04561.14 EDO15527.1 - 1.7e-42 145.2 2.7 4.4e-42 143.9 2.7 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_7 PF04560.20 EDO15527.1 - 1.1e-33 115.5 0.9 2.7e-33 114.2 0.2 2.1 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_4 PF04566.13 EDO15527.1 - 1.1e-25 89.6 0.5 3.7e-25 88.0 0.5 2.0 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_3 PF04565.16 EDO15527.1 - 1.2e-18 67.0 0.7 4.4e-18 65.2 0.0 2.2 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_5 PF04567.17 EDO15527.1 - 2.2e-11 44.1 0.8 8.7e-11 42.2 0.8 2.1 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 DUF370 PF04025.12 EDO15527.1 - 0.11 12.6 0.3 0.35 11.0 0.3 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF370) Tfb2 PF03849.14 EDO15528.1 - 7.4e-140 465.9 1.7 9.6e-140 465.6 1.7 1.1 1 0 0 1 1 1 1 Transcription factor Tfb2 Tfb2_C PF18307.1 EDO15528.1 - 4.4e-22 78.3 0.8 1.3e-21 76.7 0.8 1.9 1 0 0 1 1 1 1 Transcription factor Tfb2 (p52) C-terminal domain Helicase_C_3 PF13625.6 EDO15528.1 - 2.6e-06 27.6 0.1 7.5e-06 26.1 0.0 1.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain RRM_1 PF00076.22 EDO15529.1 - 9.4e-08 31.8 0.0 2.3e-07 30.5 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Tim54 PF11711.8 EDO15529.1 - 0.078 11.7 11.3 0.13 11.1 11.3 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 PNISR PF15996.5 EDO15529.1 - 0.24 11.7 16.4 0.064 13.5 12.7 1.8 2 0 0 2 2 2 0 Arginine/serine-rich protein PNISR DUF4770 PF15994.5 EDO15529.1 - 0.32 11.2 16.5 0.78 10.0 16.5 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) RR_TM4-6 PF06459.12 EDO15529.1 - 1.1 9.0 13.3 1.9 8.3 13.3 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 TFIIA PF03153.13 EDO15529.1 - 1.2 9.0 35.2 0.013 15.5 20.8 2.2 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit SLC12 PF03522.15 EDO15529.1 - 2.1 7.3 14.2 0.34 9.9 9.0 1.9 2 0 0 2 2 2 0 Solute carrier family 12 Zip PF02535.22 EDO15529.1 - 2.2 7.4 8.7 4.8 6.3 8.7 1.5 1 0 0 1 1 1 0 ZIP Zinc transporter MRI PF15325.6 EDO15529.1 - 2.3 9.3 5.9 56 4.9 4.4 2.5 2 0 0 2 2 2 0 Modulator of retrovirus infection RP-C_C PF11800.8 EDO15529.1 - 2.9 7.9 13.0 5 7.1 10.6 2.1 2 0 0 2 2 2 0 Replication protein C C-terminal region Membralin PF09746.9 EDO15529.1 - 3 6.8 7.4 6.4 5.7 7.4 1.5 1 0 0 1 1 1 0 Tumour-associated protein Rtf2 PF04641.12 EDO15529.1 - 3.2 7.0 12.2 5.2 6.4 12.2 1.3 1 0 0 1 1 1 0 Rtf2 RING-finger DUF5308 PF17233.2 EDO15529.1 - 3.4 7.9 11.5 0.81 9.9 6.6 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5308) Piezo_RRas_bdg PF12166.8 EDO15529.1 - 4.3 6.5 15.5 0.16 11.2 7.8 2.0 2 0 0 2 2 2 0 Piezo non-specific cation channel, R-Ras-binding domain TERB2 PF15101.6 EDO15529.1 - 8.3 6.4 19.4 2.8 8.0 14.5 2.1 2 0 0 2 2 2 0 Telomere-associated protein TERB2 Roughex PF06020.11 EDO15529.1 - 8.4 5.4 10.7 14 4.6 10.7 1.3 1 0 0 1 1 1 0 Drosophila roughex protein CPSF100_C PF13299.6 EDO15529.1 - 8.5 6.5 11.1 3.2 7.9 8.3 1.7 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Myb_DNA-binding PF00249.31 EDO15530.1 - 1.9e-14 53.6 1.0 4.3e-11 42.8 0.1 3.0 2 1 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EDO15530.1 - 6.5e-11 42.3 2.2 4.2e-09 36.5 0.7 2.6 2 0 0 2 2 2 2 Myb-like DNA-binding domain PPV_E1_N PF00524.18 EDO15530.1 - 0.26 11.7 4.6 0.16 12.4 1.9 2.0 2 0 0 2 2 2 0 E1 Protein, N terminal domain DUF3439 PF11921.8 EDO15530.1 - 0.26 11.2 5.7 1.2 9.1 5.7 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) TatD_DNase PF01026.21 EDO15531.1 - 1.2e-35 123.2 0.0 1.7e-35 122.6 0.0 1.2 1 0 0 1 1 1 1 TatD related DNase PP2C PF00481.21 EDO15532.1 - 9.8e-79 264.6 0.0 1.5e-78 264.0 0.0 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C PTH2 PF01981.16 EDO15533.1 - 9.5e-44 148.4 0.1 1.3e-43 148.0 0.1 1.2 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 FAM176 PF14851.6 EDO15533.1 - 0.0013 18.4 0.1 0.002 17.8 0.1 1.2 1 0 0 1 1 1 1 FAM176 family Sporozoite_P67 PF05642.11 EDO15533.1 - 0.096 10.8 4.7 0.13 10.3 4.7 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen RXT2_N PF08595.11 EDO15533.1 - 0.12 12.4 3.2 0.19 11.8 3.2 1.2 1 0 0 1 1 1 0 RXT2-like, N-terminal Pox_Ag35 PF03286.14 EDO15533.1 - 0.17 11.6 1.5 0.26 11.1 1.5 1.2 1 0 0 1 1 1 0 Pox virus Ag35 surface protein GP24_25 PF17388.2 EDO15533.1 - 0.49 10.4 2.5 19 5.2 0.0 2.3 2 0 0 2 2 2 0 Tail assembly gene products 24 & 25 YL1 PF05764.13 EDO15533.1 - 0.67 10.0 9.2 0.9 9.6 9.2 1.1 1 0 0 1 1 1 0 YL1 nuclear protein CENP-B_dimeris PF09026.10 EDO15533.1 - 0.9 10.0 7.1 1.4 9.3 7.1 1.3 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DNA_pol_phi PF04931.13 EDO15533.1 - 1.4 6.9 8.0 1.7 6.6 8.0 1.1 1 0 0 1 1 1 0 DNA polymerase phi DUF2457 PF10446.9 EDO15533.1 - 1.5 7.9 7.0 2 7.5 7.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) RNA_pol_3_Rpc31 PF11705.8 EDO15533.1 - 6.9 6.9 12.3 9.7 6.4 12.3 1.1 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 AAA-ATPase_like PF09820.9 EDO15534.1 - 0.011 15.1 0.0 0.019 14.4 0.0 1.4 2 0 0 2 2 2 0 Predicted AAA-ATPase Cmc1 PF08583.10 EDO15535.1 - 1.7e-18 66.4 6.9 1.7e-18 66.4 6.9 1.6 2 0 0 2 2 2 1 Cytochrome c oxidase biogenesis protein Cmc1 like NDUF_B7 PF05676.13 EDO15535.1 - 0.0018 18.0 1.6 0.0037 16.9 1.6 1.6 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) CBM_14 PF01607.24 EDO15535.1 - 0.061 13.5 0.7 0.087 13.0 0.7 1.3 1 0 0 1 1 1 0 Chitin binding Peritrophin-A domain Sel1 PF08238.12 EDO15536.1 - 8.7e-42 140.6 11.1 1.9e-05 25.2 0.0 7.5 7 0 0 7 7 7 7 Sel1 repeat ETRAMP PF09716.10 EDO15536.1 - 1.7 8.7 8.2 0.11 12.6 2.4 2.1 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) Actin PF00022.19 EDO15537.1 - 6.5e-110 367.5 0.0 2.1e-109 365.8 0.0 1.6 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 EDO15537.1 - 0.026 13.3 0.0 0.2 10.4 0.0 2.2 1 1 0 1 1 1 0 MreB/Mbl protein DUF3449 PF11931.8 EDO15538.1 - 9.6e-65 217.8 0.7 9.6e-65 217.8 0.7 2.5 3 0 0 3 3 3 1 Domain of unknown function (DUF3449) PRP9_N PF16958.5 EDO15538.1 - 1e-46 158.7 11.0 3.8e-46 156.9 11.0 2.0 1 0 0 1 1 1 1 Pre-mRNA-splicing factor PRP9 N-terminus SF3A3 PF16837.5 EDO15538.1 - 1.4e-16 60.8 3.7 1.4e-16 60.8 3.7 2.7 3 0 0 3 3 3 1 Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 zf-C2H2_jaz PF12171.8 EDO15538.1 - 9e-08 32.2 12.6 2.2e-07 31.0 0.1 3.3 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EDO15538.1 - 3.1e-05 24.2 8.7 0.00069 19.9 0.1 3.0 3 0 0 3 3 3 2 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 EDO15538.1 - 0.002 18.4 3.7 0.073 13.4 0.1 2.8 2 0 0 2 2 2 1 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.6 EDO15538.1 - 0.0024 18.6 3.5 0.55 11.2 0.3 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger zf-U1 PF06220.12 EDO15538.1 - 0.013 15.2 1.0 0.013 15.2 1.0 2.1 2 0 0 2 2 2 0 U1 zinc finger ING PF12998.7 EDO15538.1 - 2.6 8.7 8.0 0.8 10.3 0.2 3.5 3 1 0 3 3 3 0 Inhibitor of growth proteins N-terminal histone-binding DUF2175 PF09943.9 EDO15538.1 - 8.6 6.7 11.0 1.4 9.3 1.8 3.5 3 1 0 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2175) tRNA_Me_trans PF03054.16 EDO15539.1 - 5.4e-115 384.0 0.0 6.2e-115 383.8 0.0 1.0 1 0 0 1 1 1 1 tRNA methyl transferase NAD_synthase PF02540.17 EDO15539.1 - 0.0023 17.1 0.1 0.054 12.6 0.0 2.6 3 0 0 3 3 3 1 NAD synthase Exo_endo_phos PF03372.23 EDO15540.1 - 0.088 12.3 0.0 0.28 10.7 0.0 1.8 2 0 0 2 2 2 0 Endonuclease/Exonuclease/phosphatase family SIR2 PF02146.17 EDO15541.1 - 2.4e-63 213.2 0.0 4.5e-63 212.4 0.0 1.5 1 0 0 1 1 1 1 Sir2 family DUF592 PF04574.13 EDO15541.1 - 2e-55 186.8 4.7 2e-55 186.8 4.7 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF592) TPP_enzyme_M PF00205.22 EDO15541.1 - 0.0023 17.6 0.2 1.2 8.8 0.0 2.7 3 0 0 3 3 3 2 Thiamine pyrophosphate enzyme, central domain Viral_env_E26 PF11050.8 EDO15541.1 - 0.15 11.4 0.1 0.29 10.5 0.1 1.4 1 0 0 1 1 1 0 Virus envelope protein E26 DNA_pol_phi PF04931.13 EDO15541.1 - 3.1 5.8 7.3 5.1 5.1 7.3 1.3 1 0 0 1 1 1 0 DNA polymerase phi PglZ PF08665.12 EDO15542.1 - 0.055 13.6 0.9 0.11 12.6 0.0 1.8 2 0 0 2 2 2 0 PglZ domain PAPS_reduct PF01507.19 EDO15543.1 - 7.8e-30 104.2 0.0 1.9e-29 102.9 0.0 1.7 2 0 0 2 2 2 1 Phosphoadenosine phosphosulfate reductase family DAGK_cat PF00781.24 EDO15544.1 - 2.5e-25 88.5 0.0 4.1e-25 87.8 0.0 1.4 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain TFIIA PF03153.13 EDO15544.1 - 0.56 10.2 1.8 0.85 9.5 1.8 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Ras PF00071.22 EDO15545.1 - 1.3e-57 194.0 0.6 1.5e-57 193.7 0.6 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EDO15545.1 - 9.6e-38 129.1 0.2 1.9e-37 128.2 0.2 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EDO15545.1 - 3.4e-16 59.2 0.4 5.1e-16 58.6 0.4 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 EDO15545.1 - 4.7e-06 26.6 0.1 0.062 13.2 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase SRPRB PF09439.10 EDO15545.1 - 1.2e-05 24.8 0.3 6.2e-05 22.5 0.0 1.9 1 1 1 2 2 2 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 EDO15545.1 - 1.4e-05 25.1 0.0 2.6e-05 24.3 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EDO15545.1 - 0.00013 21.4 0.3 0.00017 21.1 0.3 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EDO15545.1 - 0.00021 20.9 0.2 0.0022 17.6 0.2 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain PduV-EutP PF10662.9 EDO15545.1 - 0.0049 16.6 0.8 0.052 13.3 0.8 2.2 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation AAA_7 PF12775.7 EDO15545.1 - 0.0053 16.3 0.0 0.0085 15.6 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region ATPase_2 PF01637.18 EDO15545.1 - 0.0061 16.5 0.6 0.046 13.6 0.0 2.0 1 1 1 2 2 2 1 ATPase domain predominantly from Archaea AAA_24 PF13479.6 EDO15545.1 - 0.013 15.3 0.4 0.036 13.8 0.1 1.7 1 1 0 2 2 2 0 AAA domain AAA_22 PF13401.6 EDO15545.1 - 0.021 15.1 0.0 0.061 13.6 0.0 1.7 1 1 0 2 2 2 0 AAA domain AAA_16 PF13191.6 EDO15545.1 - 0.039 14.3 0.0 0.075 13.4 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain ResIII PF04851.15 EDO15545.1 - 0.057 13.4 0.6 0.12 12.4 0.6 1.6 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit NACHT PF05729.12 EDO15545.1 - 0.087 12.7 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 NACHT domain TIR_2 PF13676.6 EDO15545.1 - 0.091 13.4 0.0 0.15 12.7 0.0 1.4 1 0 0 1 1 1 0 TIR domain Ribosomal_S28e PF01200.18 EDO15547.1 - 4.4e-32 109.9 2.4 4.8e-32 109.7 2.4 1.0 1 0 0 1 1 1 1 Ribosomal protein S28e XLF PF09302.11 EDO15548.1 - 2.8e-05 24.4 0.9 5.8e-05 23.3 0.9 1.5 1 0 0 1 1 1 1 XLF-Cernunnos, XRcc4-like factor, NHEJ component DUF3447 PF11929.8 EDO15548.1 - 0.25 11.3 4.0 0.81 9.7 3.9 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF3447) Zn_clus PF00172.18 EDO15549.1 - 1.8e-08 34.4 6.5 5.1e-08 32.9 6.5 1.8 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Adenine_glyco PF03352.13 EDO15549.1 - 0.041 13.6 0.0 0.041 13.6 0.0 1.8 2 0 0 2 2 2 0 Methyladenine glycosylase Longin PF13774.6 EDO15550.1 - 3.4e-21 75.1 0.3 5.8e-21 74.3 0.3 1.4 1 0 0 1 1 1 1 Regulated-SNARE-like domain Synaptobrevin PF00957.21 EDO15550.1 - 4.2e-17 61.7 0.3 6.4e-17 61.1 0.3 1.3 1 0 0 1 1 1 1 Synaptobrevin DUF1664 PF07889.12 EDO15550.1 - 0.027 14.5 2.5 0.027 14.5 2.5 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Phi-29_GP16_7 PF06720.11 EDO15550.1 - 0.039 13.8 0.7 0.063 13.1 0.7 1.3 1 0 0 1 1 1 0 Bacteriophage phi-29 early protein GP16.7 E1-E2_ATPase PF00122.20 EDO15550.1 - 0.14 11.6 0.0 0.21 11.1 0.0 1.3 1 0 0 1 1 1 0 E1-E2 ATPase DcpS PF05652.12 EDO15551.1 - 4.1e-34 117.5 0.1 8.3e-34 116.6 0.1 1.5 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme (DcpS) N-terminal DcpS_C PF11969.8 EDO15551.1 - 1.2e-30 106.4 0.4 3.7e-30 104.7 0.1 1.9 2 0 0 2 2 2 1 Scavenger mRNA decapping enzyme C-term binding BBS2_N PF14781.6 EDO15551.1 - 0.061 13.2 0.0 5.2 7.0 0.0 2.7 3 0 0 3 3 3 0 Ciliary BBSome complex subunit 2, N-terminal Med4 PF10018.9 EDO15552.1 - 7.9e-43 146.4 3.3 1.7e-42 145.3 3.3 1.6 1 1 0 1 1 1 1 Vitamin-D-receptor interacting Mediator subunit 4 DUF3281 PF11685.8 EDO15552.1 - 0.068 12.5 0.0 0.1 12.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3281) MBOAT PF03062.19 EDO15553.1 - 1.4e-69 235.1 13.0 1.7e-69 234.9 12.1 1.6 1 1 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family Nucleos_tra2_N PF01773.20 EDO15553.1 - 0.032 14.8 0.1 0.81 10.3 0.1 2.7 2 0 0 2 2 2 0 Na+ dependent nucleoside transporter N-terminus Cnd1 PF12717.7 EDO15554.1 - 7.1e-51 172.5 7.0 9.6e-44 149.3 0.1 5.2 4 1 1 5 5 5 3 non-SMC mitotic condensation complex subunit 1 Cnd1_N PF12922.7 EDO15554.1 - 8.1e-49 165.7 0.3 3.3e-48 163.7 0.3 2.2 1 0 0 1 1 1 1 non-SMC mitotic condensation complex subunit 1, N-term HEAT PF02985.22 EDO15554.1 - 1.1e-12 47.0 3.2 0.045 14.0 0.0 5.9 5 0 0 5 5 5 4 HEAT repeat HEAT_2 PF13646.6 EDO15554.1 - 4.5e-09 36.6 0.0 0.0098 16.3 0.0 3.9 3 1 0 3 3 3 2 HEAT repeats HEAT_EZ PF13513.6 EDO15554.1 - 2.4e-05 24.7 0.2 28 5.3 0.1 4.9 4 0 0 4 4 4 0 HEAT-like repeat RTP1_C1 PF10363.9 EDO15554.1 - 0.001 19.2 0.7 0.55 10.4 0.0 4.4 4 1 1 5 5 5 2 Required for nuclear transport of RNA pol II C-terminus 1 DUF924 PF06041.11 EDO15554.1 - 0.023 14.8 0.0 0.07 13.2 0.0 1.8 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF924) AA_permease_2 PF13520.6 EDO15555.1 - 1.1e-84 284.8 45.0 1.4e-84 284.4 45.0 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EDO15555.1 - 2e-18 66.3 42.0 3e-18 65.7 42.0 1.2 1 0 0 1 1 1 1 Amino acid permease Bromodomain PF00439.25 EDO15556.1 - 4e-26 90.9 7.1 2.9e-14 52.9 1.0 2.8 2 0 0 2 2 2 2 Bromodomain BAH PF01426.18 EDO15556.1 - 4.4e-23 81.4 0.2 3.8e-22 78.4 0.0 2.5 2 0 0 2 2 2 1 BAH domain Lyase_1 PF00206.20 EDO15557.1 - 5.4e-24 85.2 0.0 8.8e-24 84.5 0.0 1.3 1 0 0 1 1 1 1 Lyase ADSL_C PF10397.9 EDO15557.1 - 3.3e-16 59.6 0.0 1.9e-15 57.1 0.0 2.3 2 0 0 2 2 2 1 Adenylosuccinate lyase C-terminus DUF1331 PF07048.11 EDO15557.1 - 0.064 12.9 0.6 0.14 11.9 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1331) Folliculin PF11704.8 EDO15558.1 - 7.1e-44 149.9 0.4 1.2e-43 149.1 0.4 1.3 1 1 0 1 1 1 1 Vesicle coat protein involved in Golgi to plasma membrane transport Pkinase PF00069.25 EDO15559.1 - 2.1e-68 230.5 0.7 5.2e-66 222.7 0.7 2.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO15559.1 - 3.4e-47 160.9 0.2 3.6e-46 157.6 0.2 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase Ras_bdg_2 PF14847.6 EDO15559.1 - 6.9e-35 119.4 0.1 6.9e-35 119.4 0.1 2.4 3 0 0 3 3 3 1 Ras-binding domain of Byr2 SAM_1 PF00536.30 EDO15559.1 - 1.2e-08 35.3 0.0 4.5e-08 33.4 0.0 2.0 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 EDO15559.1 - 2.1e-08 34.2 2.1 2.9e-08 33.7 0.0 2.3 3 0 0 3 3 3 1 SAM domain (Sterile alpha motif) Kinase-like PF14531.6 EDO15559.1 - 1.9e-05 24.1 0.0 0.00081 18.8 0.0 2.4 2 0 0 2 2 2 1 Kinase-like SAM_4 PF18017.1 EDO15559.1 - 0.00015 21.6 0.2 0.0008 19.3 0.1 2.3 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) Pkinase_fungal PF17667.1 EDO15559.1 - 0.0038 16.1 0.0 0.0038 16.1 0.0 2.3 2 1 0 2 2 2 1 Fungal protein kinase EF-hand_7 PF13499.6 EDO15560.1 - 3.9e-10 40.0 1.7 1.5e-07 31.8 0.0 3.0 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EDO15560.1 - 9.3e-07 28.3 1.3 0.0063 16.3 0.0 4.2 3 1 1 4 4 4 1 EF-hand domain EF-hand_1 PF00036.32 EDO15560.1 - 9e-06 24.9 0.2 0.36 10.5 0.0 4.4 4 0 0 4 4 4 2 EF hand EF-hand_8 PF13833.6 EDO15560.1 - 0.0099 15.7 0.4 2.5 8.0 0.0 3.5 3 1 1 4 4 4 1 EF-hand domain pair Caldesmon PF02029.15 EDO15560.1 - 0.058 12.1 1.8 0.087 11.6 1.8 1.2 1 0 0 1 1 1 0 Caldesmon Septin PF00735.18 EDO15561.1 - 5.7e-95 317.8 0.7 1e-94 317.0 0.7 1.4 1 0 0 1 1 1 1 Septin GTP_EFTU PF00009.27 EDO15561.1 - 1.5e-05 24.6 0.4 0.00083 18.9 0.0 2.5 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EDO15561.1 - 0.00012 22.1 0.0 0.00031 20.8 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 EDO15561.1 - 0.00024 21.2 6.3 1.4 9.0 0.2 3.7 2 1 1 3 3 3 3 Dynamin family RsgA_GTPase PF03193.16 EDO15561.1 - 0.00063 19.7 3.7 0.0007 19.5 0.2 2.6 3 1 0 3 3 3 1 RsgA GTPase AAA_16 PF13191.6 EDO15561.1 - 0.023 15.1 0.2 0.41 11.0 0.0 2.3 2 0 0 2 2 2 0 AAA ATPase domain AIG1 PF04548.16 EDO15561.1 - 0.035 13.4 0.2 0.035 13.4 0.2 2.4 2 1 0 2 2 2 0 AIG1 family PIN_4 PF13638.6 EDO15562.1 - 0.00029 21.1 0.4 0.0007 19.9 0.0 1.8 2 1 0 2 2 2 1 PIN domain Hydrolase_4 PF12146.8 EDO15563.1 - 1.2e-47 162.2 0.0 1.4e-47 161.9 0.0 1.0 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EDO15563.1 - 2.4e-23 83.1 0.0 3.3e-23 82.6 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EDO15563.1 - 2.5e-12 47.9 0.0 2.8e-12 47.7 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Chlorophyllase2 PF12740.7 EDO15563.1 - 0.0044 16.0 0.0 0.007 15.3 0.0 1.2 1 0 0 1 1 1 1 Chlorophyllase enzyme DLH PF01738.18 EDO15563.1 - 0.081 12.5 0.1 6 6.4 0.0 2.5 2 1 0 2 2 2 0 Dienelactone hydrolase family DUF572 PF04502.13 EDO15564.1 - 5.7e-46 157.7 12.3 7.4e-46 157.3 12.3 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF572) DDE_Tnp_IS1 PF03400.13 EDO15564.1 - 0.01 16.2 0.1 0.058 13.7 0.0 2.0 2 0 0 2 2 2 0 IS1 transposase Mu-like_Com PF10122.9 EDO15564.1 - 0.029 13.8 0.3 0.14 11.6 0.0 2.1 2 0 0 2 2 2 0 Mu-like prophage protein Com DUF5352 PF17303.2 EDO15564.1 - 0.096 12.5 1.6 0.19 11.5 1.6 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5352) zf_UBZ PF18439.1 EDO15564.1 - 0.35 10.5 1.7 8.7 6.0 0.1 2.8 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger Prominin PF05478.11 EDO15564.1 - 2 6.2 9.2 3.4 5.5 9.2 1.2 1 0 0 1 1 1 0 Prominin Trypan_PARP PF05887.11 EDO15565.1 - 0.031 14.3 0.4 0.031 14.3 0.4 1.6 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) TbpB_A PF17484.2 EDO15566.1 - 0.054 14.2 0.7 0.089 13.5 0.7 1.3 1 0 0 1 1 1 0 N-Lobe handle Tf-binding protein B zf-SNAP50_C PF12251.8 EDO15566.1 - 0.08 12.6 0.3 0.13 11.9 0.3 1.3 1 0 0 1 1 1 0 snRNA-activating protein of 50kDa MW C terminal Peptidase_A22B PF04258.13 EDO15567.1 - 8.4e-81 271.6 11.6 1.2e-80 271.1 11.6 1.2 1 0 0 1 1 1 1 Signal peptide peptidase SPP PF06550.11 EDO15567.1 - 0.00039 20.0 6.1 0.00039 20.0 6.1 2.1 2 1 0 2 2 2 1 Signal-peptide peptidase, presenilin aspartyl protease bZIP_2 PF07716.15 EDO15568.1 - 2.5e-12 46.7 8.3 4.3e-12 45.9 8.3 1.4 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.21 EDO15568.1 - 1e-08 35.1 9.6 2.2e-08 34.0 9.6 1.5 1 0 0 1 1 1 1 bZIP transcription factor KIAA1328 PF15369.6 EDO15568.1 - 0.0036 17.2 0.1 0.0044 16.9 0.1 1.3 1 0 0 1 1 1 1 Uncharacterised protein KIAA1328 bZIP_Maf PF03131.17 EDO15568.1 - 0.015 15.8 5.6 0.035 14.6 5.6 1.6 1 0 0 1 1 1 0 bZIP Maf transcription factor VGPC1_C PF16799.5 EDO15568.1 - 0.065 13.2 3.5 0.13 12.2 3.5 1.5 1 0 0 1 1 1 0 C-terminal membrane-localisation domain of ion-channel, VCN1 DivIC PF04977.15 EDO15568.1 - 0.21 11.4 2.6 0.58 10.0 2.6 1.8 1 0 0 1 1 1 0 Septum formation initiator Urm1 PF09138.11 EDO15569.1 - 3.5e-35 120.2 1.0 3.9e-35 120.1 1.0 1.0 1 0 0 1 1 1 1 Urm1 (Ubiquitin related modifier) ThiS PF02597.20 EDO15569.1 - 0.00023 21.7 0.1 0.00028 21.5 0.1 1.2 1 0 0 1 1 1 1 ThiS family UEV PF05743.13 EDO15570.1 - 1.3e-27 96.0 0.1 2.9e-27 94.9 0.1 1.6 1 0 0 1 1 1 1 UEV domain Vps23_core PF09454.10 EDO15570.1 - 5.3e-24 83.9 0.9 1.6e-23 82.4 0.3 2.1 2 0 0 2 2 2 1 Vps23 core domain FlaC_arch PF05377.11 EDO15570.1 - 0.017 15.5 1.4 0.074 13.5 1.4 2.1 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) ALS_ss_C PF10369.9 EDO15571.1 - 1.7e-16 60.2 0.0 1.5e-15 57.1 0.0 2.6 3 0 0 3 3 3 1 Small subunit of acetolactate synthase ACT PF01842.25 EDO15571.1 - 1.3e-13 50.4 0.1 2.5e-13 49.5 0.1 1.5 1 0 0 1 1 1 1 ACT domain ACT_5 PF13710.6 EDO15571.1 - 5.6e-08 32.5 0.0 1.1e-07 31.6 0.0 1.5 1 0 0 1 1 1 1 ACT domain Limkain-b1 PF11608.8 EDO15571.1 - 0.00093 19.2 0.0 0.0042 17.1 0.0 2.0 2 0 0 2 2 2 1 Limkain b1 ACT_4 PF13291.6 EDO15571.1 - 0.07 13.7 0.1 0.79 10.3 0.0 2.3 2 0 0 2 2 2 0 ACT domain Ribosomal_L27_C PF18471.1 EDO15572.1 - 9.9e-89 296.9 25.4 1.3e-88 296.5 25.4 1.1 1 0 0 1 1 1 1 Ribosomal L27 protein C-terminal domain Ribosomal_L27 PF01016.19 EDO15572.1 - 1.2e-32 111.7 0.5 2.3e-32 110.9 0.5 1.5 1 0 0 1 1 1 1 Ribosomal L27 protein DUF1542 PF07564.11 EDO15572.1 - 0.016 15.3 0.4 0.016 15.3 0.4 2.2 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1542) RRM_1 PF00076.22 EDO15573.1 - 5.9e-60 199.0 0.0 1.3e-19 69.8 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EDO15573.1 - 0.00019 21.0 0.0 0.15 11.6 0.0 3.0 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PB1 PF00564.24 EDO15573.1 - 0.026 14.5 0.0 12 5.9 0.0 2.8 2 0 0 2 2 2 0 PB1 domain RRM_7 PF16367.5 EDO15573.1 - 0.06 13.5 0.0 12 6.1 0.0 2.4 2 0 0 2 2 2 0 RNA recognition motif RRM_occluded PF16842.5 EDO15573.1 - 0.13 12.2 0.0 2.3 8.2 0.0 2.5 3 0 0 3 3 3 0 Occluded RNA-recognition motif RRM_Rrp7 PF17799.1 EDO15573.1 - 0.18 11.6 0.0 11 5.8 0.0 2.8 3 0 0 3 3 3 0 Rrp7 RRM-like N-terminal domain WD40 PF00400.32 EDO15574.1 - 1.5e-44 149.1 18.8 1.7e-10 41.3 0.1 8.0 8 0 0 8 8 8 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDO15574.1 - 1.5e-16 60.4 1.9 0.013 15.8 0.0 5.8 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EDO15574.1 - 7.3e-10 38.1 9.8 0.011 14.4 0.1 4.9 1 1 4 5 5 5 4 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 EDO15574.1 - 4.7e-07 29.1 0.6 0.43 9.5 0.0 4.7 1 1 4 5 5 5 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nucleoporin_N PF08801.11 EDO15574.1 - 7.3e-07 28.3 0.6 0.08 11.7 0.0 3.8 1 1 3 4 4 4 2 Nup133 N terminal like Frtz PF11768.8 EDO15574.1 - 3.3e-05 22.4 0.0 0.00015 20.3 0.0 2.0 2 0 0 2 2 2 1 WD repeat-containing and planar cell polarity effector protein Fritz Hira PF07569.11 EDO15574.1 - 8.8e-05 22.3 0.2 1.1 8.9 0.0 4.1 2 1 1 3 3 3 2 TUP1-like enhancer of split Cytochrom_D1 PF02239.16 EDO15574.1 - 0.00031 19.4 0.0 0.089 11.3 0.0 2.2 1 1 1 2 2 2 2 Cytochrome D1 heme domain Nbas_N PF15492.6 EDO15574.1 - 0.0011 18.4 0.3 1.4 8.2 0.2 3.0 2 1 1 3 3 3 2 Neuroblastoma-amplified sequence, N terminal PALB2_WD40 PF16756.5 EDO15574.1 - 0.002 17.1 1.7 0.014 14.3 0.0 2.7 3 0 0 3 3 3 1 Partner and localizer of BRCA2 WD40 domain HPS3_N PF14761.6 EDO15574.1 - 0.01 15.4 0.0 0.42 10.1 0.0 2.7 2 1 0 3 3 3 1 Hermansky-Pudlak syndrome 3 Coatomer_WDAD PF04053.14 EDO15574.1 - 0.023 13.8 0.0 0.073 12.1 0.0 1.7 1 1 0 2 2 2 0 Coatomer WD associated region DUF3589 PF12141.8 EDO15575.1 - 1.4e-81 274.6 9.7 2.4e-79 267.2 9.7 2.5 1 1 0 1 1 1 1 Beta-mannosyltransferases Renin_r PF07850.14 EDO15575.1 - 0.081 13.5 1.0 22 5.7 0.2 2.8 2 0 0 2 2 2 0 Renin receptor-like protein DUF2456 PF10445.9 EDO15575.1 - 0.11 12.6 0.3 0.28 11.3 0.3 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2456) DKCLD PF08068.12 EDO15576.1 - 3.4e-32 110.3 0.2 3.4e-31 107.1 0.3 2.2 2 0 0 2 2 2 1 DKCLD (NUC011) domain TruB_C_2 PF16198.5 EDO15576.1 - 3.4e-23 81.6 0.4 6.8e-23 80.6 0.4 1.6 1 0 0 1 1 1 1 tRNA pseudouridylate synthase B C-terminal domain TruB_N PF01509.18 EDO15576.1 - 2.2e-20 73.6 5.9 4.1e-19 69.4 0.0 3.6 2 1 0 2 2 2 1 TruB family pseudouridylate synthase (N terminal domain) PUA PF01472.20 EDO15576.1 - 2.4e-20 72.3 1.4 4.6e-20 71.4 1.4 1.5 1 0 0 1 1 1 1 PUA domain UPF0113 PF03657.13 EDO15576.1 - 0.02 15.1 0.0 0.053 13.8 0.0 1.7 1 0 0 1 1 1 0 UPF0113 PUA domain GAGA_bind PF06217.12 EDO15576.1 - 0.18 12.1 16.3 0.24 11.6 16.3 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family HAD PF12710.7 EDO15577.1 - 2e-24 87.1 0.0 2.4e-24 86.8 0.0 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Put_Phosphatase PF06888.12 EDO15577.1 - 3.8e-07 29.8 0.0 6.3e-07 29.0 0.0 1.3 1 1 0 1 1 1 1 Putative Phosphatase UMPH-1 PF05822.12 EDO15577.1 - 1.5e-05 24.6 0.0 4.4e-05 23.1 0.0 1.6 1 1 0 1 1 1 1 Pyrimidine 5'-nucleotidase (UMPH-1) HAD_2 PF13419.6 EDO15577.1 - 3.3e-05 24.0 0.0 0.0025 17.9 0.0 2.4 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EDO15577.1 - 8e-05 23.0 0.1 0.0038 17.5 0.0 2.9 2 1 1 4 4 4 1 haloacid dehalogenase-like hydrolase EF-hand_7 PF13499.6 EDO15578.1 - 1.1e-05 25.8 4.3 1.1e-05 25.7 1.0 2.2 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 EDO15578.1 - 0.041 13.8 6.4 1 9.5 0.1 3.2 3 0 0 3 3 3 0 EF-hand domain EF-hand_1 PF00036.32 EDO15578.1 - 0.33 10.6 5.5 0.71 9.6 0.1 3.2 3 0 0 3 3 3 0 EF hand PLA2_B PF01735.18 EDO15579.1 - 2.2e-83 280.3 9.7 1.8e-68 231.1 2.5 2.4 2 1 0 2 2 2 2 Lysophospholipase catalytic domain ABC_tran PF00005.27 EDO15580.1 - 3.3e-45 154.0 0.1 4.3e-23 82.3 0.0 4.2 2 2 0 2 2 2 2 ABC transporter 4HB PF17947.1 EDO15580.1 - 4.9e-28 97.0 0.1 2.7e-27 94.6 0.1 2.4 1 0 0 1 1 1 1 Four helical bundle domain AAA_21 PF13304.6 EDO15580.1 - 6.6e-16 59.0 2.8 0.0038 17.1 0.0 4.7 4 1 0 5 5 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EDO15580.1 - 1.1e-14 54.4 0.1 4.4e-06 26.3 0.0 4.1 2 2 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 EDO15580.1 - 4.9e-11 43.5 1.6 0.00072 20.1 0.0 3.5 3 0 0 3 3 3 2 AAA domain AAA_29 PF13555.6 EDO15580.1 - 2.4e-08 33.6 0.0 0.0084 15.8 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EDO15580.1 - 5.5e-08 32.9 0.0 0.00054 19.9 0.0 2.7 2 0 0 2 2 2 2 RsgA GTPase AAA_28 PF13521.6 EDO15580.1 - 8.5e-08 32.6 0.1 0.0098 16.2 0.0 2.6 2 0 0 2 2 2 2 AAA domain MMR_HSR1 PF01926.23 EDO15580.1 - 1.7e-07 31.3 0.0 0.0026 17.8 0.0 3.1 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_22 PF13401.6 EDO15580.1 - 2.6e-07 31.0 0.2 0.049 13.9 0.0 4.4 5 1 0 5 5 3 2 AAA domain Dynamin_N PF00350.23 EDO15580.1 - 3.4e-07 30.5 0.0 1.2e-05 25.5 0.0 2.8 2 0 0 2 2 2 1 Dynamin family RNA_helicase PF00910.22 EDO15580.1 - 9.4e-06 26.0 0.0 0.12 12.8 0.0 3.0 2 0 0 2 2 2 2 RNA helicase AAA PF00004.29 EDO15580.1 - 1.1e-05 25.8 0.0 0.69 10.3 0.0 4.4 4 0 0 4 4 3 1 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 EDO15580.1 - 1.7e-05 25.4 0.1 0.26 11.8 0.0 3.3 3 0 0 3 3 2 2 AAA domain AAA_16 PF13191.6 EDO15580.1 - 4.3e-05 24.0 0.2 0.22 11.9 0.0 3.8 4 1 0 4 4 4 1 AAA ATPase domain AAA_33 PF13671.6 EDO15580.1 - 4.7e-05 23.6 0.0 0.58 10.3 0.0 3.1 3 0 0 3 3 2 2 AAA domain ParcG PF10274.9 EDO15580.1 - 9.1e-05 22.7 0.2 0.63 10.1 0.0 2.4 2 0 0 2 2 2 2 Parkin co-regulated protein AAA_15 PF13175.6 EDO15580.1 - 0.00013 21.8 2.2 0.26 10.9 0.0 3.5 4 0 0 4 4 2 2 AAA ATPase domain MeaB PF03308.16 EDO15580.1 - 0.00026 20.0 0.1 0.41 9.6 0.0 2.4 2 0 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_27 PF13514.6 EDO15580.1 - 0.00029 20.5 0.0 0.27 10.8 0.0 2.5 2 0 0 2 2 2 1 AAA domain DUF87 PF01935.17 EDO15580.1 - 0.00044 20.4 0.4 0.37 10.8 0.0 4.3 4 0 0 4 4 4 1 Helicase HerA, central domain HEAT_2 PF13646.6 EDO15580.1 - 0.00082 19.7 1.5 0.62 10.5 0.0 2.9 1 1 1 2 2 2 1 HEAT repeats HEAT_EZ PF13513.6 EDO15580.1 - 0.0014 19.1 9.5 0.055 14.0 0.1 4.1 4 0 0 4 4 3 1 HEAT-like repeat AAA_24 PF13479.6 EDO15580.1 - 0.0017 18.1 0.0 1.3 8.7 0.0 3.1 3 0 0 3 3 2 1 AAA domain SbcCD_C PF13558.6 EDO15580.1 - 0.0019 18.4 0.2 0.59 10.4 0.0 3.3 3 1 0 3 3 2 1 Putative exonuclease SbcCD, C subunit AAA_30 PF13604.6 EDO15580.1 - 0.0022 17.7 0.1 3.8 7.2 0.1 3.2 3 0 0 3 3 3 0 AAA domain PduV-EutP PF10662.9 EDO15580.1 - 0.0024 17.6 0.0 0.28 10.9 0.0 2.9 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation G-alpha PF00503.20 EDO15580.1 - 0.0026 17.0 0.0 1.1 8.3 0.0 2.5 2 0 0 2 2 2 1 G-protein alpha subunit UME PF08064.13 EDO15580.1 - 0.0042 17.0 0.4 0.017 15.0 0.3 2.1 2 0 0 2 2 1 1 UME (NUC010) domain cobW PF02492.19 EDO15580.1 - 0.0057 16.3 0.0 4.3 6.9 0.0 3.3 3 0 0 3 3 2 0 CobW/HypB/UreG, nucleotide-binding domain NACHT PF05729.12 EDO15580.1 - 0.0057 16.6 0.0 2.8 7.8 0.0 2.8 3 0 0 3 3 2 1 NACHT domain CLASP_N PF12348.8 EDO15580.1 - 0.0059 16.2 1.0 0.048 13.2 0.7 2.4 2 1 0 2 2 1 1 CLASP N terminal AAA_14 PF13173.6 EDO15580.1 - 0.0064 16.5 0.0 8 6.5 0.0 3.6 4 0 0 4 4 3 0 AAA domain Vac14_Fab1_bd PF12755.7 EDO15580.1 - 0.0065 17.0 0.2 3.6 8.2 0.0 3.8 3 1 1 4 4 3 0 Vacuolar 14 Fab1-binding region Rad17 PF03215.15 EDO15580.1 - 0.0077 16.2 0.0 3.2 7.7 0.0 2.9 2 0 0 2 2 2 0 Rad17 P-loop domain CLP1_P PF16575.5 EDO15580.1 - 0.0088 15.9 0.0 1.2 8.9 0.0 3.1 2 0 0 2 2 2 1 mRNA cleavage and polyadenylation factor CLP1 P-loop Roc PF08477.13 EDO15580.1 - 0.019 15.1 0.0 12 6.2 0.0 2.6 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase NTPase_1 PF03266.15 EDO15580.1 - 0.024 14.5 0.1 12 5.8 0.0 2.9 2 0 0 2 2 2 0 NTPase ATPase_2 PF01637.18 EDO15580.1 - 0.029 14.3 2.0 6.1 6.7 0.0 3.4 4 0 0 4 4 3 0 ATPase domain predominantly from Archaea AAA_7 PF12775.7 EDO15580.1 - 0.03 13.9 0.0 3.6 7.1 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region T2SSE PF00437.20 EDO15580.1 - 0.034 13.2 0.0 0.27 10.2 0.0 2.2 2 0 0 2 2 2 0 Type II/IV secretion system protein IstB_IS21 PF01695.17 EDO15580.1 - 0.035 13.8 0.0 13 5.5 0.0 3.2 3 0 0 3 3 2 0 IstB-like ATP binding protein Cytidylate_kin PF02224.18 EDO15580.1 - 0.036 13.8 0.0 9.9 5.8 0.1 2.5 2 0 0 2 2 2 0 Cytidylate kinase Adaptin_N PF01602.20 EDO15580.1 - 0.043 12.4 5.6 0.29 9.6 4.1 2.4 1 1 2 3 3 3 0 Adaptin N terminal region ATP_bind_1 PF03029.17 EDO15580.1 - 0.052 13.3 0.1 7.6 6.2 0.0 2.7 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein RE_HindVP PF09519.10 EDO15580.1 - 0.055 12.5 0.1 0.096 11.7 0.1 1.3 1 0 0 1 1 1 0 HindVP restriction endonuclease Septin PF00735.18 EDO15580.1 - 0.057 12.7 0.1 2.1 7.5 0.0 2.6 3 0 0 3 3 2 0 Septin DUF3437 PF11919.8 EDO15580.1 - 0.069 13.1 2.3 0.77 9.7 0.3 3.6 3 1 0 3 3 3 0 Domain of unknown function (DUF3437) Mg_chelatase PF01078.21 EDO15580.1 - 0.071 12.5 0.5 2.6 7.4 0.0 3.0 4 0 0 4 4 3 0 Magnesium chelatase, subunit ChlI Ploopntkinase3 PF18751.1 EDO15580.1 - 0.071 13.0 0.0 15 5.4 0.0 2.5 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 TsaE PF02367.17 EDO15580.1 - 0.075 13.0 0.1 7.1 6.6 0.1 2.5 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE MutS_V PF00488.21 EDO15580.1 - 0.086 12.9 0.1 6.4 6.8 0.1 2.6 2 0 0 2 2 2 0 MutS domain V Zeta_toxin PF06414.12 EDO15580.1 - 0.11 11.8 0.1 18 4.5 0.0 2.7 2 0 0 2 2 2 0 Zeta toxin MukB PF04310.12 EDO15580.1 - 0.11 12.3 0.1 12 5.6 0.0 2.6 2 0 0 2 2 2 0 MukB N-terminal FeoB_N PF02421.18 EDO15580.1 - 0.15 11.6 0.3 1.2 8.6 0.1 2.4 2 0 0 2 2 2 0 Ferrous iron transport protein B AAA_13 PF13166.6 EDO15580.1 - 0.27 9.8 7.9 3.2 6.3 0.0 4.0 5 0 0 5 5 5 0 AAA domain AAA_17 PF13207.6 EDO15580.1 - 0.41 11.1 2.4 32 4.9 0.4 3.5 2 1 0 2 2 2 0 AAA domain HEAT PF02985.22 EDO15580.1 - 0.79 10.1 5.0 30 5.2 0.0 4.3 7 0 0 7 7 2 0 HEAT repeat Pkinase PF00069.25 EDO15581.1 - 1.5e-59 201.5 0.0 3.4e-58 197.1 0.0 2.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO15581.1 - 2.5e-24 86.0 0.1 5.8e-23 81.5 0.1 2.5 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDO15581.1 - 2.1e-05 24.0 0.2 0.17 11.2 0.1 2.4 2 0 0 2 2 2 2 Kinase-like Kdo PF06293.14 EDO15581.1 - 0.00039 19.8 0.1 0.00068 19.0 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EDO15581.1 - 0.12 12.2 0.0 0.32 10.9 0.0 1.6 2 0 0 2 2 2 0 Phosphotransferase enzyme family PSY3 PF16836.5 EDO15582.1 - 5.6e-38 130.7 1.8 6e-38 130.5 1.8 1.0 1 0 0 1 1 1 1 Shu complex component Psy3, DNA-binding description Acyltransferase PF01553.21 EDO15583.1 - 2.2e-31 108.3 0.0 3.6e-31 107.6 0.0 1.4 1 0 0 1 1 1 1 Acyltransferase Glyco_trans_1_3 PF13528.6 EDO15583.1 - 0.027 13.7 0.0 0.047 12.9 0.0 1.3 1 0 0 1 1 1 0 Glycosyl transferase family 1 FBPase PF00316.20 EDO15584.1 - 1.7e-78 262.5 0.4 2.2e-78 262.1 0.4 1.1 1 0 0 1 1 1 1 Fructose-1-6-bisphosphatase, N-terminal domain Inositol_P PF00459.25 EDO15584.1 - 0.075 12.5 0.0 0.14 11.6 0.0 1.4 1 0 0 1 1 1 0 Inositol monophosphatase family MLVIN_C PF18697.1 EDO15585.1 - 0.00072 19.6 0.2 0.0018 18.3 0.1 1.7 2 0 0 2 2 2 1 Murine leukemia virus (MLV) integrase (IN) C-terminal domain C2 PF00168.30 EDO15585.1 - 0.031 14.6 0.0 0.043 14.1 0.0 1.3 1 0 0 1 1 1 0 C2 domain DUF4794 PF16042.5 EDO15585.1 - 0.071 14.1 0.0 0.12 13.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4794) Golgin_A5 PF09787.9 EDO15586.1 - 0.0084 15.6 8.1 0.0084 15.6 8.1 1.4 2 0 0 2 2 2 1 Golgin subfamily A member 5 Trns_repr_metal PF02583.17 EDO15586.1 - 0.013 15.9 1.9 0.035 14.5 1.9 1.8 1 0 0 1 1 1 0 Metal-sensitive transcriptional repressor DUF812 PF05667.11 EDO15586.1 - 0.026 13.4 9.0 0.042 12.7 9.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF812) MAD PF05557.13 EDO15586.1 - 0.053 11.9 9.8 0.082 11.3 9.8 1.2 1 0 0 1 1 1 0 Mitotic checkpoint protein YabA PF06156.13 EDO15586.1 - 0.063 13.9 9.7 0.07 13.8 7.8 2.1 2 1 0 2 2 2 0 Initiation control protein YabA NPV_P10 PF05531.12 EDO15586.1 - 0.071 13.6 1.2 0.63 10.5 0.3 2.7 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Gp_dh_C PF02800.20 EDO15586.1 - 0.091 12.4 0.2 0.16 11.6 0.2 1.4 1 0 0 1 1 1 0 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Laminin_II PF06009.12 EDO15586.1 - 0.11 12.5 5.6 0.06 13.4 2.3 2.0 1 1 0 1 1 1 0 Laminin Domain II DUF948 PF06103.11 EDO15586.1 - 0.17 12.2 1.2 0.37 11.1 0.7 1.9 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) Leu_zip PF15294.6 EDO15586.1 - 0.25 10.8 11.8 0.06 12.8 8.3 1.7 2 0 0 2 2 2 0 Leucine zipper FapA PF03961.13 EDO15586.1 - 0.42 9.2 5.5 1.3 7.5 5.8 1.7 2 0 0 2 2 2 0 Flagellar Assembly Protein A FlxA PF14282.6 EDO15586.1 - 0.44 10.6 11.3 0.82 9.7 11.3 1.4 1 0 0 1 1 1 0 FlxA-like protein TolA_bind_tri PF16331.5 EDO15586.1 - 0.64 10.1 9.7 0.072 13.2 3.8 2.3 2 0 0 2 2 2 0 TolA binding protein trimerisation CLZ PF16526.5 EDO15586.1 - 0.75 10.2 8.7 0.089 13.2 1.9 2.5 2 0 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels HMMR_N PF15905.5 EDO15586.1 - 1.1 8.6 10.6 0.52 9.7 8.0 1.6 2 0 0 2 2 2 0 Hyaluronan mediated motility receptor N-terminal DUF2730 PF10805.8 EDO15586.1 - 1.2 9.2 5.6 1.2 9.2 1.7 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2730) Spc7 PF08317.11 EDO15586.1 - 1.5 7.6 10.0 1.2 8.0 7.8 1.8 2 0 0 2 2 2 0 Spc7 kinetochore protein MitMem_reg PF13012.6 EDO15586.1 - 1.9 9.0 6.3 16 5.9 4.6 2.8 2 1 0 2 2 2 0 Maintenance of mitochondrial structure and function Fib_alpha PF08702.10 EDO15586.1 - 2.9 8.1 10.2 7.3 6.8 10.2 1.7 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family CC2-LZ PF16516.5 EDO15586.1 - 10 6.6 10.4 0.4 11.1 2.9 2.3 2 1 1 3 3 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator Ank_4 PF13637.6 EDO15587.1 - 3.3e-09 37.1 0.0 0.0007 20.1 0.0 3.2 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 EDO15587.1 - 2e-08 34.7 0.1 0.0016 19.0 0.0 2.8 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) KilA-N PF04383.13 EDO15587.1 - 2.3e-06 27.4 0.3 2.3e-06 27.4 0.3 3.6 2 2 0 2 2 2 1 KilA-N domain Ank_5 PF13857.6 EDO15587.1 - 0.0014 18.9 0.1 1.1 9.7 0.0 3.1 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 EDO15587.1 - 0.013 15.9 0.0 54 4.5 0.0 3.5 3 0 0 3 3 3 0 Ankyrin repeat Ank_3 PF13606.6 EDO15587.1 - 0.017 15.6 0.0 13 6.7 0.0 3.9 4 0 0 4 4 4 0 Ankyrin repeat Y_phosphatase3 PF13350.6 EDO15588.1 - 1.6e-55 188.6 0.0 5.3e-55 186.9 0.0 1.8 2 0 0 2 2 2 1 Tyrosine phosphatase family Hydrolase_4 PF12146.8 EDO15588.1 - 2e-05 24.0 0.0 8.9e-05 21.9 0.0 1.9 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Y_phosphatase2 PF03162.13 EDO15588.1 - 0.00038 20.1 1.1 0.004 16.7 0.5 2.8 1 1 0 1 1 1 1 Tyrosine phosphatase family Abhydrolase_1 PF00561.20 EDO15588.1 - 0.0017 18.1 0.1 0.0094 15.6 0.0 2.1 2 0 0 2 2 2 1 alpha/beta hydrolase fold CodY PF06018.14 EDO15588.1 - 0.073 12.6 0.1 0.34 10.4 0.0 2.1 2 0 0 2 2 2 0 CodY GAF-like domain Abhydrolase_6 PF12697.7 EDO15588.1 - 0.2 12.2 0.0 0.35 11.5 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family CRAL_TRIO PF00650.20 EDO15589.1 - 6.2e-42 143.0 0.7 9.8e-42 142.4 0.7 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 EDO15589.1 - 2.7e-10 40.3 0.2 9e-10 38.6 0.2 1.9 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.6 EDO15589.1 - 4.3e-09 36.7 0.4 9.7e-09 35.5 0.4 1.6 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain YicC_N PF03755.13 EDO15589.1 - 0.037 14.5 0.1 0.15 12.6 0.0 2.0 1 1 1 2 2 2 0 YicC-like family, N-terminal region Herpes_IE1 PF07340.11 EDO15589.1 - 0.071 12.0 0.1 0.1 11.5 0.1 1.1 1 0 0 1 1 1 0 Cytomegalovirus IE1 protein Cdc13_OB4_dimer PF18233.1 EDO15590.1 - 0.032 14.4 0.2 12 6.1 0.0 3.1 2 0 0 2 2 2 0 Cdc13 OB4 dimerization domain AAA_23 PF13476.6 EDO15591.1 - 6.6e-21 75.7 6.8 6.6e-21 75.7 6.8 5.6 1 1 2 3 3 1 1 AAA domain SMC_N PF02463.19 EDO15591.1 - 9.8e-14 51.3 45.2 4.4e-13 49.2 45.2 2.3 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 EDO15591.1 - 9.5e-05 22.7 0.0 0.00045 20.5 0.0 2.3 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_29 PF13555.6 EDO15591.1 - 0.00087 19.0 0.0 0.0023 17.6 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_15 PF13175.6 EDO15591.1 - 0.0017 18.2 50.8 0.0017 18.2 50.8 4.5 1 1 0 2 2 1 1 AAA ATPase domain Zeta_toxin PF06414.12 EDO15591.1 - 0.003 16.9 2.8 0.24 10.6 0.0 3.5 3 1 0 3 3 3 1 Zeta toxin FtsK_SpoIIIE PF01580.18 EDO15591.1 - 0.022 14.1 0.0 0.088 12.1 0.0 2.0 1 0 0 1 1 1 0 FtsK/SpoIIIE family ABC_tran PF00005.27 EDO15591.1 - 0.1 13.1 0.1 0.1 13.1 0.1 5.7 3 2 0 3 3 2 0 ABC transporter AAA_21 PF13304.6 EDO15591.1 - 0.27 11.0 33.8 0.13 12.1 1.1 4.7 2 2 2 4 4 3 0 AAA domain, putative AbiEii toxin, Type IV TA system HrpB7 PF09486.10 EDO15591.1 - 1 9.7 25.0 0.04 14.3 7.2 3.9 5 0 0 5 5 4 0 Bacterial type III secretion protein (HrpB7) DUF3584 PF12128.8 EDO15591.1 - 8.6 3.7 64.6 0.28 8.6 21.7 3.3 2 1 1 3 3 3 0 Protein of unknown function (DUF3584) Uso1_p115_head PF04869.14 EDO15592.1 - 5.5e-104 347.7 0.2 5.5e-104 347.7 0.2 2.8 2 0 0 2 2 2 1 Uso1 / p115 like vesicle tethering protein, head region Uso1_p115_C PF04871.13 EDO15592.1 - 1.2e-16 61.2 27.0 1.2e-16 61.2 27.0 20.8 1 1 18 19 19 19 1 Uso1 / p115 like vesicle tethering protein, C terminal region Filament PF00038.21 EDO15592.1 - 6.2e-08 32.6 348.6 0.017 14.7 47.0 13.4 1 1 9 10 10 10 8 Intermediate filament protein SHE3 PF17078.5 EDO15592.1 - 5.6e-07 29.5 11.7 5.6e-07 29.5 11.7 15.0 1 1 12 14 14 14 2 SWI5-dependent HO expression protein 3 Spc7 PF08317.11 EDO15592.1 - 7.4e-07 28.3 405.6 0.014 14.3 23.9 16.1 2 1 13 16 16 16 11 Spc7 kinetochore protein CENP-F_leu_zip PF10473.9 EDO15592.1 - 0.00015 21.8 22.5 0.00015 21.8 22.5 21.0 1 1 20 21 21 21 4 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ATG16 PF08614.11 EDO15592.1 - 0.0038 17.5 26.6 0.0038 17.5 26.6 18.5 1 1 18 19 19 19 7 Autophagy protein 16 (ATG16) Arm_vescicular PF18770.1 EDO15592.1 - 0.065 13.2 0.0 0.15 12.0 0.0 1.7 1 0 0 1 1 1 0 Armadillo tether-repeat of vescicular transport factor Rad52_Rad22 PF04098.15 EDO15593.1 - 1.5e-40 138.6 0.1 1.8e-40 138.4 0.1 1.1 1 0 0 1 1 1 1 Rad52/22 family double-strand break repair protein Spore_YunB PF09560.10 EDO15593.1 - 0.1 12.6 0.0 0.21 11.6 0.0 1.5 1 0 0 1 1 1 0 Sporulation protein YunB (Spo_YunB) IKI3 PF04762.12 EDO15594.1 - 0 1172.4 3.8 0 1172.1 3.8 1.1 1 0 0 1 1 1 1 IKI3 family ANAPC4_WD40 PF12894.7 EDO15594.1 - 0.0016 18.7 0.9 1.8 8.9 0.2 4.6 4 1 1 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain TPR_2 PF07719.17 EDO15594.1 - 0.017 15.2 1.2 0.15 12.3 0.4 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.28 EDO15594.1 - 0.16 11.8 2.5 0.54 10.2 0.6 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat RIBIOP_C PF04950.12 EDO15595.1 - 1.1e-104 349.9 0.1 2.3e-104 348.9 0.0 1.6 1 1 0 1 1 1 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal AARP2CN PF08142.12 EDO15595.1 - 7e-23 80.5 0.0 1.6e-22 79.3 0.0 1.7 1 0 0 1 1 1 1 AARP2CN (NUC121) domain PA28_beta PF02252.18 EDO15596.1 - 0.04 13.6 0.1 0.58 9.8 0.1 2.5 2 0 0 2 2 2 0 Proteasome activator pa28 beta subunit Phage_connect_1 PF05135.13 EDO15596.1 - 0.054 14.0 2.7 0.24 11.9 2.7 2.2 1 0 0 1 1 1 0 Phage gp6-like head-tail connector protein HNF-1_N PF04814.13 EDO15596.1 - 0.061 13.9 0.1 0.15 12.7 0.1 1.6 1 0 0 1 1 1 0 Hepatocyte nuclear factor 1 (HNF-1), N terminus tRNA-synt_His PF13393.6 EDO15596.1 - 0.069 12.4 1.9 6.9 5.8 0.0 3.1 4 0 0 4 4 4 0 Histidyl-tRNA synthetase UQ_con PF00179.26 EDO15597.1 - 1e-39 135.4 0.1 1.2e-39 135.2 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EDO15597.1 - 8.2e-05 22.3 0.0 9.8e-05 22.1 0.0 1.1 1 0 0 1 1 1 1 Prokaryotic E2 family B Pex19 PF04614.12 EDO15598.1 - 2.8e-56 191.1 15.8 3.4e-56 190.8 15.8 1.1 1 0 0 1 1 1 1 Pex19 protein family EMC3_TMCO1 PF01956.16 EDO15598.1 - 0.66 9.7 2.7 0.54 10.0 0.3 2.0 1 1 1 2 2 2 0 Integral membrane protein EMC3/TMCO1-like GET2 PF08690.10 EDO15598.1 - 5.8 6.5 15.4 0.76 9.4 3.4 2.8 1 1 2 3 3 3 0 GET complex subunit GET2 zf-RING_5 PF14634.6 EDO15599.1 - 4.2e-08 33.0 5.1 9.6e-08 31.9 5.1 1.6 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 EDO15599.1 - 0.0017 18.2 5.1 0.0053 16.6 5.1 1.8 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 EDO15599.1 - 0.21 11.9 5.8 0.42 11.0 5.8 1.5 1 0 0 1 1 1 0 Ring finger domain zf-RING_6 PF14835.6 EDO15599.1 - 0.3 11.0 2.3 0.6 10.0 2.3 1.4 1 0 0 1 1 1 0 zf-RING of BARD1-type protein HR1 PF02185.16 EDO15599.1 - 0.35 11.0 4.0 0.58 10.3 0.6 2.5 2 0 0 2 2 2 0 Hr1 repeat zf-C3HC4_2 PF13923.6 EDO15599.1 - 2.7 7.9 5.6 6.6 6.7 5.6 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) FliJ PF02050.16 EDO15599.1 - 2.8 8.2 5.5 1.6 9.0 1.1 2.5 2 1 0 2 2 2 0 Flagellar FliJ protein Sec1 PF00995.23 EDO15600.1 - 5.8e-84 283.4 19.5 7e-84 283.1 19.5 1.0 1 0 0 1 1 1 1 Sec1 family DUF1128 PF06569.11 EDO15600.1 - 0.043 13.8 0.4 0.21 11.6 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1128) IL11 PF07400.11 EDO15600.1 - 0.29 10.8 2.7 1.2 8.8 0.3 2.6 2 0 0 2 2 2 0 Interleukin 11 AAA PF00004.29 EDO15601.1 - 2.5e-90 299.7 0.0 1.1e-43 148.8 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EDO15601.1 - 4.4e-25 87.2 0.4 1.2e-11 44.2 0.2 2.6 2 0 0 2 2 2 2 AAA+ lid domain RuvB_N PF05496.12 EDO15601.1 - 5.1e-13 49.1 0.0 2.1e-05 24.3 0.0 2.8 3 0 0 3 3 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EDO15601.1 - 3.3e-12 47.1 1.0 5.2e-06 26.9 0.0 4.3 3 2 0 4 4 3 2 AAA ATPase domain AAA_5 PF07728.14 EDO15601.1 - 3.2e-11 43.4 0.0 0.00014 21.9 0.0 3.7 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 EDO15601.1 - 6.5e-09 36.1 0.0 0.0025 17.9 0.0 3.2 2 1 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 EDO15601.1 - 2.4e-08 34.4 1.4 0.0033 17.7 0.0 4.5 2 2 1 3 3 3 1 AAA domain AAA_14 PF13173.6 EDO15601.1 - 5.5e-08 32.9 0.0 0.0011 19.0 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_33 PF13671.6 EDO15601.1 - 2.7e-07 30.8 0.0 0.0037 17.4 0.0 2.5 2 0 0 2 2 2 2 AAA domain TIP49 PF06068.13 EDO15601.1 - 1.4e-06 27.7 0.0 0.0073 15.6 0.0 2.4 2 0 0 2 2 2 2 TIP49 P-loop domain Bac_DnaA PF00308.18 EDO15601.1 - 2.2e-06 27.7 0.0 0.0013 18.6 0.0 2.8 2 1 0 2 2 2 1 Bacterial dnaA protein Rad17 PF03215.15 EDO15601.1 - 1.5e-05 25.0 0.1 0.0074 16.2 0.0 3.1 2 2 1 3 3 3 1 Rad17 P-loop domain Mg_chelatase PF01078.21 EDO15601.1 - 2.9e-05 23.5 0.2 0.13 11.6 0.0 2.6 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 EDO15601.1 - 4.5e-05 23.8 0.0 0.53 10.7 0.0 2.9 2 0 0 2 2 2 2 RNA helicase AAA_11 PF13086.6 EDO15601.1 - 8.5e-05 22.5 0.0 0.035 13.9 0.0 3.1 3 0 0 3 3 3 1 AAA domain TsaE PF02367.17 EDO15601.1 - 0.00011 22.2 0.0 0.26 11.3 0.0 2.5 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_28 PF13521.6 EDO15601.1 - 0.00021 21.6 0.0 1 9.6 0.0 2.8 3 0 0 3 3 2 2 AAA domain AAA_7 PF12775.7 EDO15601.1 - 0.00021 20.9 0.1 0.49 9.9 0.0 2.6 2 1 0 2 2 2 2 P-loop containing dynein motor region AAA_25 PF13481.6 EDO15601.1 - 0.00023 20.8 6.8 2.7 7.5 0.0 4.9 4 1 1 5 5 5 2 AAA domain CDC48_N PF02359.18 EDO15601.1 - 0.00062 19.9 0.1 0.0031 17.7 0.0 2.1 2 0 0 2 2 2 1 Cell division protein 48 (CDC48), N-terminal domain Vps4_C PF09336.10 EDO15601.1 - 0.00065 19.6 0.3 0.58 10.2 0.0 3.7 3 0 0 3 3 3 1 Vps4 C terminal oligomerisation domain Sigma54_activ_2 PF14532.6 EDO15601.1 - 0.00084 19.5 0.0 1.2 9.3 0.0 2.8 2 0 0 2 2 2 1 Sigma-54 interaction domain ABC_tran PF00005.27 EDO15601.1 - 0.00092 19.7 0.0 0.1 13.1 0.0 3.0 3 1 0 3 3 2 1 ABC transporter AAA_3 PF07726.11 EDO15601.1 - 0.0021 17.9 0.0 2 8.3 0.0 2.7 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 EDO15601.1 - 0.0022 18.6 0.3 0.84 10.2 0.0 3.5 4 0 0 4 4 3 1 AAA domain Viral_helicase1 PF01443.18 EDO15601.1 - 0.0028 17.5 0.0 0.018 14.8 0.0 2.2 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase NACHT PF05729.12 EDO15601.1 - 0.004 17.1 0.1 0.13 12.1 0.0 3.2 4 0 0 4 4 4 1 NACHT domain IstB_IS21 PF01695.17 EDO15601.1 - 0.0041 16.9 0.0 2.7 7.7 0.0 2.3 2 0 0 2 2 2 1 IstB-like ATP binding protein PIH1 PF08190.12 EDO15601.1 - 0.0064 16.0 0.0 0.015 14.8 0.0 1.5 1 0 0 1 1 1 1 PIH1 N-terminal domain AAA_30 PF13604.6 EDO15601.1 - 0.0087 15.8 0.0 0.097 12.4 0.0 2.5 2 0 0 2 2 2 1 AAA domain Sigma54_activat PF00158.26 EDO15601.1 - 0.0089 15.7 0.0 4.5 7.0 0.0 3.7 2 2 0 2 2 2 0 Sigma-54 interaction domain AAA_24 PF13479.6 EDO15601.1 - 0.011 15.4 0.0 0.69 9.6 0.0 2.5 2 0 0 2 2 2 0 AAA domain ATPase PF06745.13 EDO15601.1 - 0.016 14.6 0.0 6.3 6.1 0.0 3.2 3 0 0 3 3 3 0 KaiC AAA_19 PF13245.6 EDO15601.1 - 0.019 15.3 0.2 0.55 10.6 0.1 2.8 2 1 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 EDO15601.1 - 0.021 14.1 0.1 3.7 6.8 0.0 2.5 2 0 0 2 2 2 0 Zeta toxin DUF815 PF05673.13 EDO15601.1 - 0.03 13.5 0.0 1.2 8.3 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF815) Trigger_C PF05698.14 EDO15601.1 - 0.048 13.7 1.5 1.4 8.9 0.1 2.5 2 0 0 2 2 2 0 Bacterial trigger factor protein (TF) C-terminus NB-ARC PF00931.22 EDO15601.1 - 0.073 12.2 0.0 3.8 6.6 0.0 2.9 3 0 0 3 3 3 0 NB-ARC domain AFG1_ATPase PF03969.16 EDO15601.1 - 0.11 11.4 0.0 0.36 9.6 0.0 1.8 2 0 0 2 2 2 0 AFG1-like ATPase DUF3829 PF12889.7 EDO15601.1 - 0.11 11.9 0.9 3.2 7.2 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3829) ATPase_2 PF01637.18 EDO15601.1 - 0.13 12.1 0.1 20 5.0 0.0 3.2 2 2 1 3 3 3 0 ATPase domain predominantly from Archaea ING PF12998.7 EDO15601.1 - 0.14 12.8 0.5 0.49 11.0 0.5 1.9 1 0 0 1 1 1 0 Inhibitor of growth proteins N-terminal histone-binding Dus PF01207.17 EDO15602.1 - 6.2e-43 147.1 0.2 1.2e-32 113.3 0.0 2.5 3 0 0 3 3 3 2 Dihydrouridine synthase (Dus) zf-CCCH_4 PF18044.1 EDO15602.1 - 3e-05 23.7 10.5 0.00018 21.2 1.6 3.1 2 1 0 2 2 2 2 CCCH-type zinc finger zf-CCCH PF00642.24 EDO15602.1 - 0.0045 16.9 9.0 0.006 16.5 0.2 2.9 3 0 0 3 3 3 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 EDO15602.1 - 0.015 15.4 0.5 0.015 15.4 0.5 2.7 3 0 0 3 3 3 0 Zinc finger domain zf-CCCH_2 PF14608.6 EDO15602.1 - 0.18 12.3 4.4 0.27 11.7 0.1 2.7 2 0 0 2 2 2 0 RNA-binding, Nab2-type zinc finger Torus PF16131.5 EDO15602.1 - 1.1 10.0 9.7 2.4 8.9 2.1 2.8 1 1 1 2 2 2 0 Torus domain GATA PF00320.27 EDO15603.1 - 6.5e-17 60.9 3.8 1.2e-16 60.0 3.8 1.5 1 0 0 1 1 1 1 GATA zinc finger DUF2387 PF09526.10 EDO15603.1 - 0.046 13.9 0.1 0.2 11.8 0.1 2.1 1 0 0 1 1 1 0 Probable metal-binding protein (DUF2387) Ctf8 PF09696.10 EDO15603.1 - 8 6.8 8.3 0.7 10.2 1.1 2.6 2 0 0 2 2 2 0 Ctf8 XPG_I PF00867.18 EDO15604.1 - 2e-26 92.2 0.0 5.7e-26 90.7 0.0 1.8 2 0 0 2 2 2 1 XPG I-region XPG_N PF00752.17 EDO15604.1 - 5.8e-07 29.9 0.0 1.4e-06 28.7 0.0 1.6 1 0 0 1 1 1 1 XPG N-terminal domain RET_CLD3 PF17812.1 EDO15604.1 - 0.044 14.0 0.1 0.08 13.2 0.1 1.4 1 0 0 1 1 1 0 RET Cadherin like domain 3 Sortilin-Vps10 PF15902.5 EDO15605.1 - 7.9e-91 305.1 25.0 4.9e-55 187.1 17.7 3.3 2 1 0 2 2 2 2 Sortilin, neurotensin receptor 3, Sortilin_C PF15901.5 EDO15605.1 - 8.3e-31 107.6 4.4 2.1e-30 106.3 4.4 1.8 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal BNR PF02012.20 EDO15605.1 - 1e-15 55.1 34.2 0.24 11.6 0.0 11.5 10 0 0 10 10 10 7 BNR/Asp-box repeat Mo-co_dimer PF03404.16 EDO15605.1 - 0.00059 19.9 3.6 2.9 7.9 0.0 4.8 3 2 1 5 5 5 2 Mo-co oxidoreductase dimerisation domain PSII_BNR PF14870.6 EDO15605.1 - 0.0009 18.6 6.6 0.35 10.1 0.2 4.2 5 1 0 5 5 5 2 Photosynthesis system II assembly factor YCF48 DUF2147 PF09917.9 EDO15605.1 - 0.042 14.5 0.2 0.2 12.3 0.0 2.2 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2147) CHB_HEX_C PF03174.13 EDO15605.1 - 0.11 12.5 1.9 15 5.6 0.0 4.0 3 0 0 3 3 3 0 Chitobiase/beta-hexosaminidase C-terminal domain BNR_6 PF15899.5 EDO15605.1 - 0.12 12.5 9.7 47 4.5 0.0 6.8 7 0 0 7 7 7 0 BNR-Asp box repeat Cyclin_N PF00134.23 EDO15606.1 - 9.7e-40 135.2 0.6 4.7e-39 133.0 0.1 2.4 3 0 0 3 3 3 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 EDO15606.1 - 2.2e-33 114.9 0.2 6.8e-33 113.3 0.0 2.0 2 0 0 2 2 2 1 Cyclin, C-terminal domain Cyclin_N PF00134.23 EDO15607.1 - 1e-40 138.4 1.3 1.2e-39 135.0 1.2 2.3 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 EDO15607.1 - 1.8e-10 40.9 0.1 1.4e-09 38.1 0.0 2.3 2 0 0 2 2 2 1 Cyclin, C-terminal domain TPR_1 PF00515.28 EDO15608.1 - 2.8e-39 131.4 33.7 1.9e-05 24.3 0.2 10.7 10 1 0 10 10 10 7 Tetratricopeptide repeat TPR_2 PF07719.17 EDO15608.1 - 1.4e-37 124.8 28.4 0.00013 21.8 0.1 10.2 10 0 0 10 10 10 8 Tetratricopeptide repeat TPR_8 PF13181.6 EDO15608.1 - 1.4e-26 90.4 21.7 0.0077 16.4 0.0 11.0 10 1 0 10 10 10 7 Tetratricopeptide repeat TPR_17 PF13431.6 EDO15608.1 - 1.5e-23 81.4 23.3 0.00033 20.8 0.1 10.5 10 0 0 10 10 10 6 Tetratricopeptide repeat TPR_11 PF13414.6 EDO15608.1 - 5.2e-22 77.3 21.9 4.3e-05 23.1 0.1 8.6 5 2 4 9 9 9 5 TPR repeat TPR_14 PF13428.6 EDO15608.1 - 2.5e-19 68.3 13.0 0.015 16.1 0.1 9.6 3 2 7 10 10 10 8 Tetratricopeptide repeat TPR_12 PF13424.6 EDO15608.1 - 3e-16 59.5 23.2 0.0015 18.7 2.1 7.3 3 2 4 7 7 7 6 Tetratricopeptide repeat TPR_16 PF13432.6 EDO15608.1 - 5.9e-16 58.8 11.8 0.0024 18.5 1.5 6.2 4 3 3 7 7 7 4 Tetratricopeptide repeat TPR_7 PF13176.6 EDO15608.1 - 1.1e-15 56.4 14.0 0.0032 17.4 0.1 9.4 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_9 PF13371.6 EDO15608.1 - 1.4e-13 50.8 8.5 0.011 15.9 0.0 6.1 3 1 3 6 6 6 5 Tetratricopeptide repeat TPR_19 PF14559.6 EDO15608.1 - 3.3e-13 50.0 11.8 0.0046 17.4 0.7 5.9 3 3 1 5 5 5 5 Tetratricopeptide repeat TPR_6 PF13174.6 EDO15608.1 - 5.6e-13 48.6 8.1 3.7 8.4 0.0 8.6 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_15 PF13429.6 EDO15608.1 - 1.4e-10 40.9 8.7 0.0044 16.3 0.1 5.5 1 1 4 5 5 5 3 Tetratricopeptide repeat ANAPC3 PF12895.7 EDO15608.1 - 2.9e-08 33.8 11.1 0.0014 18.8 1.3 3.8 2 1 1 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_MalT PF17874.1 EDO15608.1 - 1.8e-05 24.3 1.3 0.056 12.8 0.2 4.2 2 2 3 5 5 5 2 MalT-like TPR region TPR_10 PF13374.6 EDO15608.1 - 0.0003 20.5 18.0 0.026 14.4 0.0 7.0 8 0 0 8 8 8 1 Tetratricopeptide repeat Ubiq-assoc PF09145.10 EDO15608.1 - 0.11 12.5 0.2 9 6.4 0.0 3.4 3 0 0 3 3 3 0 Ubiquitin-associated Macoilin PF09726.9 EDO15608.1 - 0.53 8.8 22.5 0.69 8.4 22.5 1.2 1 0 0 1 1 1 0 Macoilin family NARP1 PF12569.8 EDO15608.1 - 0.61 8.9 0.0 0.61 8.9 0.0 4.7 4 2 1 5 5 4 0 NMDA receptor-regulated protein 1 SNF2_N PF00176.23 EDO15609.1 - 7.2e-53 179.5 0.4 4.6e-52 176.9 0.4 2.3 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EDO15609.1 - 1.1e-15 57.9 0.0 2.5e-14 53.5 0.0 2.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain zf-C3HC4 PF00097.25 EDO15609.1 - 7.1e-09 35.4 11.5 7.1e-09 35.4 11.5 2.6 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) ResIII PF04851.15 EDO15609.1 - 3.8e-08 33.5 0.0 3.8e-08 33.5 0.0 1.8 2 0 0 2 2 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EDO15609.1 - 1.2e-07 31.7 0.0 2.3e-07 30.7 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase zf-C3HC4_2 PF13923.6 EDO15609.1 - 0.0001 22.1 9.6 0.0001 22.1 9.6 2.7 2 1 1 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EDO15609.1 - 0.00036 20.3 7.6 0.00036 20.3 7.6 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EDO15609.1 - 0.0009 19.4 10.4 0.0009 19.4 10.4 2.4 2 0 0 2 2 1 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.6 EDO15609.1 - 0.0011 18.9 6.6 0.0011 18.9 6.6 2.1 2 0 0 2 2 1 1 RING-type zinc-finger MH2 PF03166.14 EDO15609.1 - 0.0058 16.9 0.0 0.018 15.3 0.0 1.9 1 1 0 1 1 1 1 MH2 domain zf-RING_2 PF13639.6 EDO15609.1 - 0.008 16.5 10.0 0.008 16.5 10.0 2.5 2 0 0 2 2 2 1 Ring finger domain Zn_Tnp_IS91 PF14319.6 EDO15609.1 - 0.014 15.4 10.9 0.023 14.7 1.5 2.5 2 0 0 2 2 2 0 Transposase zinc-binding domain zf-rbx1 PF12678.7 EDO15609.1 - 0.022 15.1 6.4 0.022 15.1 6.4 2.2 2 0 0 2 2 1 0 RING-H2 zinc finger domain YqfQ PF14181.6 EDO15609.1 - 4.3 7.5 7.5 8.6 6.5 7.5 1.4 1 0 0 1 1 1 0 YqfQ-like protein FlhC PF05280.11 EDO15609.1 - 7.4 6.3 8.7 16 5.1 1.5 2.5 2 0 0 2 2 2 0 Flagellar transcriptional activator (FlhC) NAD_binding_4 PF07993.12 EDO15610.1 - 7.4e-72 241.6 0.0 1.1e-71 241.0 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein AMP-binding PF00501.28 EDO15610.1 - 1.7e-69 234.5 0.0 2.1e-69 234.1 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme PP-binding PF00550.25 EDO15610.1 - 1.4e-14 54.2 0.0 3.4e-14 53.0 0.0 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site Epimerase PF01370.21 EDO15610.1 - 7.8e-07 28.8 0.0 1.3e-06 28.0 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family AMP-binding_C PF13193.6 EDO15610.1 - 2.8e-06 28.2 0.0 1.6e-05 25.8 0.0 2.2 1 1 0 1 1 1 1 AMP-binding enzyme C-terminal domain Condensation PF00668.20 EDO15610.1 - 1.3e-05 24.0 1.9 0.00013 20.8 1.9 2.0 2 0 0 2 2 2 1 Condensation domain GDP_Man_Dehyd PF16363.5 EDO15610.1 - 0.16 11.3 0.0 0.26 10.6 0.0 1.3 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Not3 PF04065.15 EDO15611.1 - 2.4e-63 213.7 35.7 2.4e-63 213.7 35.7 3.3 3 2 0 3 3 3 1 Not1 N-terminal domain, CCR4-Not complex component NOT2_3_5 PF04153.18 EDO15611.1 - 6.8e-36 123.2 7.4 6.8e-36 123.2 7.4 3.2 4 1 0 4 4 4 1 NOT2 / NOT3 / NOT5 family Cep57_MT_bd PF06657.13 EDO15611.1 - 1 9.8 9.2 0.89 10.1 3.4 3.2 2 1 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 CRAL_TRIO_N PF03765.15 EDO15611.1 - 1.4 9.1 5.7 1.1 9.6 1.0 3.0 2 0 0 2 2 2 0 CRAL/TRIO, N-terminal domain Transketolase_N PF00456.21 EDO15612.1 - 2.3e-151 503.5 0.0 4.2e-151 502.6 0.0 1.4 2 0 0 2 2 2 1 Transketolase, thiamine diphosphate binding domain Transket_pyr PF02779.24 EDO15612.1 - 1.8e-45 154.8 0.0 3.2e-45 154.0 0.0 1.4 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 EDO15612.1 - 1.2e-10 41.3 0.0 2.5e-10 40.3 0.0 1.5 1 0 0 1 1 1 1 Transketolase, C-terminal domain E1_dh PF00676.20 EDO15612.1 - 0.00026 20.1 0.0 0.00045 19.3 0.0 1.3 1 0 0 1 1 1 1 Dehydrogenase E1 component DXP_synthase_N PF13292.6 EDO15612.1 - 0.0024 17.1 0.0 0.0041 16.4 0.0 1.4 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase XRN_N PF03159.18 EDO15613.1 - 1e-94 316.5 0.5 2e-94 315.6 0.0 1.8 2 0 0 2 2 2 1 XRN 5'-3' exonuclease N-terminus XRN_M PF17846.1 EDO15613.1 - 8.4e-84 282.1 9.1 8.4e-84 282.1 9.1 2.0 2 0 0 2 2 2 1 Xrn1 helical domain XRN1_D1 PF18332.1 EDO15613.1 - 3.8e-39 134.4 0.1 8.1e-39 133.4 0.1 1.6 1 0 0 1 1 1 1 Exoribonuclease Xrn1 D1 domain XRN1_D2_D3 PF18334.1 EDO15613.1 - 2.5e-18 66.0 0.7 1.1e-17 64.1 0.3 2.5 2 0 0 2 2 2 1 Exoribonuclease Xrn1 D2/D3 domain SH3_12 PF18129.1 EDO15613.1 - 4.1e-13 49.2 0.2 8.3e-13 48.2 0.2 1.5 1 0 0 1 1 1 1 Xrn1 SH3-like domain Zip PF02535.22 EDO15614.1 - 9.8e-73 245.3 3.6 1.1e-72 245.1 3.6 1.0 1 0 0 1 1 1 1 ZIP Zinc transporter Mito_carr PF00153.27 EDO15615.1 - 2.7e-74 245.2 0.5 4e-25 87.5 0.0 3.5 3 0 0 3 3 3 3 Mitochondrial carrier protein MA3 PF02847.17 EDO15615.1 - 0.032 14.2 0.0 0.62 10.1 0.0 3.1 2 1 0 2 2 2 0 MA3 domain Serine_protease PF18405.1 EDO15615.1 - 0.061 12.5 0.3 7.7 5.6 0.0 3.2 2 1 0 3 3 3 0 Gammaproteobacterial serine protease MRG PF05712.13 EDO15616.1 - 5.2e-33 114.0 0.6 5.2e-33 114.0 0.6 2.2 2 1 0 2 2 2 1 MRG Tudor-knot PF11717.8 EDO15616.1 - 1.5e-07 31.2 0.0 3.4e-07 30.0 0.0 1.7 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain DUF349 PF03993.12 EDO15616.1 - 0.042 14.1 4.4 0.11 12.8 4.4 1.7 1 0 0 1 1 1 0 Domain of Unknown Function (DUF349) UPF0242 PF06785.11 EDO15616.1 - 0.15 12.2 11.6 0.34 11.0 11.6 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Macoilin PF09726.9 EDO15616.1 - 0.18 10.4 11.4 0.22 10.0 11.4 1.1 1 0 0 1 1 1 0 Macoilin family Cucumo_2B PF03263.13 EDO15616.1 - 0.22 12.0 2.5 0.63 10.5 2.5 1.8 1 1 0 1 1 1 0 Cucumovirus protein 2B Exonuc_VII_L PF02601.15 EDO15616.1 - 0.32 10.5 5.8 0.43 10.1 5.8 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit CD52 PF15116.6 EDO15616.1 - 0.6 10.2 3.2 1.3 9.1 3.2 1.5 1 0 0 1 1 1 0 CAMPATH-1 antigen Membralin PF09746.9 EDO15616.1 - 6.6 5.7 8.0 9.5 5.1 8.0 1.2 1 0 0 1 1 1 0 Tumour-associated protein Pkinase PF00069.25 EDO15617.1 - 2.6e-19 69.6 0.1 7.3e-19 68.1 0.0 1.8 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO15617.1 - 4.2e-09 36.1 0.0 8.3e-09 35.1 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EDO15617.1 - 1.5e-05 24.0 0.0 1.5e-05 24.0 0.0 2.1 2 0 0 2 2 2 1 Fungal protein kinase AAA_34 PF13872.6 EDO15617.1 - 0.011 14.6 0.0 0.023 13.6 0.0 1.4 1 0 0 1 1 1 0 P-loop containing NTP hydrolase pore-1 KHA PF11834.8 EDO15617.1 - 0.042 13.9 0.1 0.16 12.0 0.0 2.0 2 0 0 2 2 2 0 KHA, dimerisation domain of potassium ion channel DUF3914 PF13053.6 EDO15617.1 - 0.39 11.1 3.4 0.48 10.8 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3914) Macoilin PF09726.9 EDO15617.1 - 2.3 6.7 23.2 3.3 6.2 23.2 1.2 1 0 0 1 1 1 0 Macoilin family Piezo_RRas_bdg PF12166.8 EDO15617.1 - 4.5 6.4 12.9 6.9 5.8 12.9 1.2 1 0 0 1 1 1 0 Piezo non-specific cation channel, R-Ras-binding domain DIL PF01843.19 EDO15619.1 - 0.0002 21.6 0.2 0.00062 20.0 0.1 1.9 2 0 0 2 2 2 1 DIL domain RAG2_PHD PF13341.6 EDO15619.1 - 0.083 13.0 0.0 0.3 11.2 0.0 1.9 1 0 0 1 1 1 0 RAG2 PHD domain eIF-1a PF01176.19 EDO15620.1 - 1.8e-20 72.5 0.1 2.5e-20 72.0 0.1 1.2 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 Glyco_hydro_32N PF00251.20 EDO15622.1 - 3.7e-84 282.9 10.2 5.3e-84 282.4 10.2 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 32 N-terminal domain Glyco_hydro_32C PF08244.12 EDO15622.1 - 5.1e-16 59.1 0.1 1.1e-15 57.9 0.1 1.6 1 0 0 1 1 1 1 Glycosyl hydrolases family 32 C terminal zf-C2H2 PF00096.26 EDO15623.1 - 5.5e-09 36.0 32.1 0.0009 19.6 1.4 5.5 6 0 0 6 6 6 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EDO15623.1 - 2.6e-06 27.8 26.9 0.0059 17.4 0.7 5.0 5 0 0 5 5 5 3 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EDO15623.1 - 0.00052 20.3 1.5 0.00052 20.3 1.5 5.3 6 0 0 6 6 6 2 Zinc-finger double domain zf-C2H2_jaz PF12171.8 EDO15623.1 - 0.00079 19.6 2.7 0.0071 16.6 0.6 3.2 3 0 0 3 3 3 1 Zinc-finger double-stranded RNA-binding GAGA PF09237.11 EDO15623.1 - 0.068 13.0 1.0 0.17 11.7 1.0 1.6 1 0 0 1 1 1 0 GAGA factor DUF4729 PF15866.5 EDO15623.1 - 0.14 11.4 0.1 0.14 11.4 0.1 3.3 3 1 0 3 3 3 0 Domain of unknown function (DUF4729) zf-C2H2_aberr PF17017.5 EDO15623.1 - 0.21 11.8 12.8 23 5.1 0.1 3.4 3 1 0 3 3 3 0 Aberrant zinc-finger zf-met PF12874.7 EDO15623.1 - 1.2 9.7 6.4 0.9 10.0 0.4 3.7 3 0 0 3 3 3 0 Zinc-finger of C2H2 type Sec63 PF02889.16 EDO15624.1 - 1.3e-28 99.9 0.7 2.2e-28 99.2 0.7 1.4 1 0 0 1 1 1 1 Sec63 Brl domain DEAD PF00270.29 EDO15624.1 - 6.4e-23 81.4 0.0 1.6e-22 80.1 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 EDO15624.1 - 9.1e-12 45.3 0.9 2.3e-11 44.0 0.0 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EDO15624.1 - 8.9e-10 38.9 0.3 1.5e-08 35.0 0.0 3.3 3 0 0 3 3 3 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 EDO15624.1 - 0.0021 18.3 0.0 0.01 16.1 0.0 2.1 2 0 0 2 2 2 1 AAA domain V-set_2 PF15910.5 EDO15624.1 - 0.0043 17.1 0.1 0.019 15.0 0.1 2.1 1 0 0 1 1 1 1 ICOS V-set domain AAA_19 PF13245.6 EDO15624.1 - 0.011 16.1 0.0 0.034 14.5 0.0 1.9 1 0 0 1 1 1 0 AAA domain UvrD-helicase PF00580.21 EDO15624.1 - 0.025 14.1 2.7 0.04 13.4 0.0 2.6 2 1 0 2 2 2 0 UvrD/REP helicase N-terminal domain DNA_pol_lambd_f PF10391.9 EDO15624.1 - 0.038 13.8 0.0 0.11 12.3 0.0 1.8 1 0 0 1 1 1 0 Fingers domain of DNA polymerase lambda AAA_30 PF13604.6 EDO15624.1 - 0.044 13.5 0.0 0.092 12.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain TniB PF05621.11 EDO15624.1 - 0.11 11.8 0.0 6 6.2 0.0 2.3 2 0 0 2 2 2 0 Bacterial TniB protein DUF2420 PF10336.9 EDO15625.1 - 8.9e-40 135.1 0.9 1.5e-39 134.4 0.9 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2420) eIF3_subunit PF08597.10 EDO15626.1 - 1.1e-49 169.5 18.9 1.3e-49 169.3 18.9 1.1 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit CDC45 PF02724.14 EDO15626.1 - 0.78 8.0 10.5 1.3 7.2 10.5 1.3 1 1 0 1 1 1 0 CDC45-like protein DUF4602 PF15375.6 EDO15626.1 - 1.9 8.8 13.5 3 8.1 4.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4602) Ndc80_HEC PF03801.13 EDO15627.1 - 3.3e-52 176.2 1.2 3.3e-52 176.2 1.2 2.2 2 1 0 2 2 2 1 HEC/Ndc80p family DUF5595 PF18077.1 EDO15627.1 - 2.8e-08 33.7 5.9 2.8e-08 33.7 5.9 4.9 5 2 1 6 6 6 1 Domain of unknown function (DUF5595) UPF0242 PF06785.11 EDO15627.1 - 0.073 13.2 54.5 0.6 10.2 7.0 4.5 2 2 2 4 4 4 0 Uncharacterised protein family (UPF0242) N-terminus YqbF PF14553.6 EDO15627.1 - 3.9 7.4 6.0 15 5.6 0.5 3.2 3 0 0 3 3 3 0 YqbF, hypothetical protein domain SRP40_C PF05022.12 EDO15628.1 - 3.8e-22 78.9 2.6 3.8e-22 78.9 2.6 2.2 2 0 0 2 2 2 1 SRP40, C-terminal domain DUF3336 PF11815.8 EDO15629.1 - 2.6e-34 117.9 1.4 2.6e-34 117.9 1.4 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF3336) Patatin PF01734.22 EDO15629.1 - 1e-25 91.1 0.0 2.3e-25 90.0 0.0 1.6 1 0 0 1 1 1 1 Patatin-like phospholipase U3_snoRNA_assoc PF08297.11 EDO15630.1 - 1.5e-20 73.6 5.5 1.5e-20 73.6 5.5 2.6 2 1 0 2 2 2 1 U3 snoRNA associated THF_DHG_CYH PF00763.23 EDO15631.1 - 1.9e-26 92.6 0.0 1.2e-25 90.0 0.0 2.2 3 0 0 3 3 3 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain THF_DHG_CYH_C PF02882.19 EDO15631.1 - 4.5e-16 58.6 0.0 1.8e-10 40.4 0.0 2.7 2 1 0 2 2 2 2 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain FTP PF07504.13 EDO15631.1 - 0.0078 16.0 0.3 0.02 14.7 0.3 1.7 1 0 0 1 1 1 1 Fungalysin/Thermolysin Propeptide Motif DpaA_N PF16924.5 EDO15631.1 - 0.053 13.6 0.0 0.29 11.2 0.0 2.4 2 1 0 2 2 2 0 Dipicolinate synthase subunit A N-terminal domain Lactamase_B_4 PF13691.6 EDO15632.1 - 1.3e-26 92.0 0.0 2.7e-26 91.0 0.0 1.6 1 0 0 1 1 1 1 tRNase Z endonuclease Lactamase_B_2 PF12706.7 EDO15632.1 - 2.2e-08 33.9 0.0 0.0064 16.0 0.0 2.3 2 0 0 2 2 2 2 Beta-lactamase superfamily domain MS_channel PF00924.18 EDO15632.1 - 0.12 11.9 3.7 6.1 6.3 0.4 2.5 2 0 0 2 2 2 0 Mechanosensitive ion channel Bacteriocin_IIi PF11758.8 EDO15632.1 - 0.16 11.8 0.0 0.38 10.6 0.0 1.6 1 0 0 1 1 1 0 Aureocin-like type II bacteriocin Vps5 PF09325.10 EDO15633.1 - 4.3e-70 235.9 16.1 8.7e-70 234.9 16.1 1.5 1 0 0 1 1 1 1 Vps5 C terminal like PX PF00787.24 EDO15633.1 - 1.9e-21 76.1 2.1 3.5e-21 75.3 0.2 2.5 3 0 0 3 3 3 1 PX domain GST_N_2 PF13409.6 EDO15635.1 - 2.8e-22 78.8 0.0 1e-21 77.0 0.0 2.0 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EDO15635.1 - 1.6e-11 44.1 0.0 3.8e-11 42.9 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EDO15635.1 - 0.0025 18.2 0.0 3.8 8.0 0.0 2.5 2 0 0 2 2 2 2 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EDO15635.1 - 0.027 14.7 0.2 0.09 13.0 0.2 1.7 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Cor1 PF04803.12 EDO15635.1 - 0.096 12.9 1.0 0.16 12.2 1.0 1.2 1 0 0 1 1 1 0 Cor1/Xlr/Xmr conserved region GST_C_3 PF14497.6 EDO15635.1 - 0.13 12.4 0.6 0.42 10.8 0.6 1.9 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 EDO15636.1 - 4.7e-23 81.3 0.1 2.9e-22 78.7 0.0 2.1 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EDO15636.1 - 2.1e-12 46.9 0.0 4e-12 46.0 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EDO15636.1 - 0.0082 16.5 0.0 3.6 8.1 0.0 2.6 2 0 0 2 2 2 2 Glutathione S-transferase, N-terminal domain Sec2p PF06428.11 EDO15636.1 - 0.039 13.9 0.2 0.065 13.2 0.2 1.3 1 0 0 1 1 1 0 GDP/GTP exchange factor Sec2p GST_C PF00043.25 EDO15636.1 - 0.051 13.8 0.4 0.27 11.5 0.2 2.2 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Cytochrom_C1 PF02167.15 EDO15637.1 - 2.4e-95 318.4 0.0 3e-95 318.1 0.0 1.1 1 0 0 1 1 1 1 Cytochrome C1 family Cytochrome_CBB3 PF13442.6 EDO15637.1 - 0.0011 19.2 0.0 0.0023 18.2 0.0 1.6 1 0 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C PF00034.21 EDO15637.1 - 0.0017 19.4 0.1 0.0041 18.2 0.1 1.9 1 1 0 1 1 1 1 Cytochrome c Pkinase PF00069.25 EDO15639.1 - 3.3e-58 197.1 0.0 3.9e-58 196.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO15639.1 - 5.1e-17 62.0 0.0 7.6e-17 61.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EDO15639.1 - 2.2e-07 31.1 0.0 1.2e-06 28.7 0.0 2.0 1 1 1 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EDO15639.1 - 0.016 14.8 0.0 0.031 13.9 0.0 1.5 1 0 0 1 1 1 0 Choline/ethanolamine kinase Pkinase_fungal PF17667.1 EDO15639.1 - 0.036 12.8 0.0 0.06 12.1 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase Kdo PF06293.14 EDO15639.1 - 0.095 12.0 0.0 0.16 11.3 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Sld7_N PF18636.1 EDO15640.1 - 9e-43 145.6 0.0 1.6e-42 144.8 0.0 1.4 1 0 0 1 1 1 1 Mitochondrial morphogenesis protein SLD7 N-terminal domain Sld7_C PF18596.1 EDO15640.1 - 8.9e-24 83.4 0.2 1.7e-23 82.5 0.2 1.5 1 0 0 1 1 1 1 Sld7 C-terminal domain Nrap_D2 PF17403.2 EDO15642.1 - 1.2e-50 171.3 0.7 7.7e-49 165.4 0.2 2.8 2 0 0 2 2 2 1 Nrap protein PAP/OAS-like domain Nrap_D5 PF17406.2 EDO15642.1 - 1.4e-50 171.2 0.0 3.9e-50 169.8 0.0 1.8 1 0 0 1 1 1 1 Nrap protein PAP/OAS1-like domain 5 Nrap_D4 PF17405.2 EDO15642.1 - 7.1e-50 169.3 0.2 1.2e-49 168.6 0.2 1.4 1 0 0 1 1 1 1 Nrap protein nucleotidyltransferase domain 4 Nrap PF03813.14 EDO15642.1 - 7.2e-45 152.8 4.2 1.8e-44 151.5 4.2 1.7 1 0 0 1 1 1 1 Nrap protein domain 1 Nrap_D3 PF17404.2 EDO15642.1 - 2.3e-40 138.3 0.1 5.5e-40 137.1 0.1 1.7 1 0 0 1 1 1 1 Nrap protein domain 3 Nrap_D6 PF17407.2 EDO15642.1 - 1.4e-28 99.8 0.7 3.4e-28 98.5 0.7 1.7 1 0 0 1 1 1 1 Nrap protein domain 6 ALMT PF11744.8 EDO15642.1 - 0.024 13.5 3.7 0.055 12.3 3.7 1.5 1 0 0 1 1 1 0 Aluminium activated malate transporter Sigma70_ner PF04546.13 EDO15642.1 - 0.17 11.7 17.2 0.65 9.9 13.4 2.8 2 0 0 2 2 2 0 Sigma-70, non-essential region CDC45 PF02724.14 EDO15642.1 - 1.8 6.7 11.7 3 6.0 11.7 1.2 1 0 0 1 1 1 0 CDC45-like protein Vfa1 PF08432.10 EDO15642.1 - 1.9 8.8 10.1 5 7.4 10.1 1.6 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 DNA_pol_phi PF04931.13 EDO15642.1 - 7.3 4.6 19.0 12 3.8 19.0 1.3 1 0 0 1 1 1 0 DNA polymerase phi DUF2457 PF10446.9 EDO15642.1 - 8.4 5.4 23.0 13 4.8 23.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) GCIP PF13324.6 EDO15642.1 - 9.2 5.8 10.2 19 4.8 10.2 1.4 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting DUF1746 PF08508.10 EDO15643.1 - 1.7e-07 31.6 1.4 3.4e-06 27.4 1.4 2.6 1 1 0 1 1 1 1 Fungal domain of unknown function (DUF1746) RNA_pol_A_bac PF01000.26 EDO15644.1 - 4.3e-30 104.4 0.0 1.1e-29 103.1 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 EDO15644.1 - 1.8e-21 75.3 0.0 2.6e-21 74.8 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Pmp3 PF01679.17 EDO15647.1 - 9.2e-16 57.8 7.2 9.9e-16 57.7 7.2 1.0 1 0 0 1 1 1 1 Proteolipid membrane potential modulator DEAD PF00270.29 EDO15648.1 - 3.5e-34 118.1 0.7 5.7e-34 117.4 0.2 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDO15648.1 - 3.6e-29 101.4 0.0 9e-29 100.1 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDO15648.1 - 1.3e-06 28.6 0.0 3.2e-06 27.2 0.0 1.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 EDO15648.1 - 0.0065 16.2 0.0 0.014 15.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain ChaB PF06150.12 EDO15648.1 - 0.092 13.3 0.0 0.19 12.3 0.0 1.5 1 0 0 1 1 1 0 ChaB XRN_M PF17846.1 EDO15649.1 - 2.5e-127 425.5 15.6 2.8e-95 319.9 1.9 2.6 2 1 1 3 3 3 2 Xrn1 helical domain XRN_N PF03159.18 EDO15649.1 - 4.3e-100 334.1 0.3 4.2e-99 330.9 0.0 2.2 2 0 0 2 2 2 1 XRN 5'-3' exonuclease N-terminus Acyltransferase PF01553.21 EDO15650.1 - 1.1e-06 28.4 0.0 2.4e-05 24.0 0.0 2.6 1 1 0 1 1 1 1 Acyltransferase TRAPP PF04051.16 EDO15651.1 - 5.3e-34 117.0 0.0 7.1e-34 116.6 0.0 1.1 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component DUF4541 PF15074.6 EDO15651.1 - 0.19 12.3 0.0 0.31 11.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4541) Nro1 PF12753.7 EDO15652.1 - 3.8e-170 566.3 21.9 4.3e-170 566.1 21.9 1.0 1 0 0 1 1 1 1 Nuclear pore complex subunit Nro1 FAST_1 PF06743.15 EDO15652.1 - 0.03 14.2 1.4 4.6 7.3 0.1 3.6 3 0 0 3 3 3 0 FAST kinase-like protein, subdomain 1 BIRC6 PF12356.8 EDO15652.1 - 0.04 13.3 0.1 0.086 12.3 0.1 1.5 1 0 0 1 1 1 0 Baculoviral IAP repeat-containing protein 6 TPR_19 PF14559.6 EDO15652.1 - 0.091 13.3 3.8 1.7 9.2 0.2 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EDO15652.1 - 0.17 12.1 2.0 3.5 7.9 0.0 3.1 3 0 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 Mvb12 PF09452.10 EDO15652.1 - 0.58 10.6 4.3 0.63 10.5 0.0 2.8 3 0 0 3 3 3 0 ESCRT-I subunit Mvb12 Hydrolase_like PF13242.6 EDO15653.1 - 1.4e-27 95.5 0.0 2.6e-27 94.7 0.0 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase_6 PF13344.6 EDO15653.1 - 5.2e-26 90.7 0.0 1.5e-25 89.2 0.0 1.8 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 EDO15653.1 - 0.0078 16.3 0.1 0.87 9.6 0.0 3.2 2 1 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EDO15653.1 - 0.13 12.5 0.0 5.2 7.3 0.0 2.8 2 1 0 2 2 2 0 haloacid dehalogenase-like hydrolase DUF1611 PF07755.11 EDO15653.1 - 0.16 11.3 0.0 0.25 10.6 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1611_C) P-loop domain zf-AN1 PF01428.16 EDO15654.1 - 5.4e-09 36.1 11.9 1.1e-08 35.1 11.9 1.5 1 0 0 1 1 1 1 AN1-like Zinc finger Flavoprotein PF02441.19 EDO15655.1 - 2.2e-51 173.7 0.2 3.9e-51 172.9 0.2 1.4 1 0 0 1 1 1 1 Flavoprotein PPP4R2 PF09184.11 EDO15655.1 - 0.00022 20.9 5.9 0.00022 20.9 5.9 2.7 3 0 0 3 3 3 1 PPP4R2 Nop14 PF04147.12 EDO15655.1 - 0.017 13.4 22.0 0.46 8.6 23.0 2.0 2 0 0 2 2 2 0 Nop14-like family RRN3 PF05327.11 EDO15655.1 - 0.31 9.5 16.3 0.5 8.9 16.3 1.3 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 NOA36 PF06524.12 EDO15655.1 - 0.61 9.4 31.8 1.1 8.5 31.8 1.3 1 0 0 1 1 1 0 NOA36 protein DNA_pol_phi PF04931.13 EDO15655.1 - 0.97 7.5 32.6 1.8 6.5 32.6 1.4 1 0 0 1 1 1 0 DNA polymerase phi CNDH2_C PF16858.5 EDO15655.1 - 5 6.9 10.8 20 5.0 7.7 2.4 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term PIN_6 PF17146.4 EDO15656.1 - 1.4e-31 108.8 0.0 3.6e-31 107.5 0.0 1.7 1 0 0 1 1 1 1 PIN domain of ribonuclease NOB1_Zn_bind PF08772.11 EDO15656.1 - 7e-25 87.0 0.5 1.7e-24 85.7 0.3 1.8 1 1 0 1 1 1 1 Nin one binding (NOB1) Zn-ribbon like zinc_ribbon_12 PF11331.8 EDO15656.1 - 0.88 9.4 3.4 2 8.3 3.4 1.6 1 0 0 1 1 1 0 Probable zinc-ribbon domain DUF2340 PF10209.9 EDO15657.1 - 4.9e-53 178.7 2.4 5.8e-53 178.4 2.4 1.0 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2340) Peptidase_C13 PF01650.18 EDO15657.1 - 0.036 13.6 0.4 0.043 13.3 0.4 1.2 1 0 0 1 1 1 0 Peptidase C13 family Imm39 PF15568.6 EDO15657.1 - 0.1 12.7 0.4 2.2 8.4 0.1 2.0 2 0 0 2 2 2 0 Immunity protein 39 DUF676 PF05057.14 EDO15658.1 - 9.1e-47 159.4 0.7 1.5e-46 158.7 0.7 1.3 1 0 0 1 1 1 1 Putative serine esterase (DUF676) PGAP1 PF07819.13 EDO15658.1 - 4.1e-07 29.9 0.2 6.5e-07 29.3 0.2 1.3 1 0 0 1 1 1 1 PGAP1-like protein Palm_thioest PF02089.15 EDO15658.1 - 3.8e-05 23.7 0.1 0.00012 22.1 0.0 1.8 2 0 0 2 2 2 1 Palmitoyl protein thioesterase bZIP_1 PF00170.21 EDO15660.1 - 6.3e-09 35.8 9.0 1.2e-08 34.9 9.0 1.4 1 0 0 1 1 1 1 bZIP transcription factor FAM199X PF15814.5 EDO15660.1 - 0.0011 18.1 5.9 0.0011 18.1 5.9 1.5 1 1 1 2 2 2 1 Protein family FAM199X bZIP_2 PF07716.15 EDO15660.1 - 0.0045 17.0 8.4 0.011 15.8 8.4 1.6 1 0 0 1 1 1 1 Basic region leucine zipper RNF111_N PF15303.6 EDO15660.1 - 0.019 14.8 0.8 0.019 14.8 0.8 1.6 2 0 0 2 2 2 0 E3 ubiquitin-protein ligase Arkadia N-terminus Cellulase PF00150.18 EDO15661.1 - 1.7e-07 31.0 16.8 1e-06 28.4 16.8 2.1 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) CK_II_beta PF01214.18 EDO15662.1 - 2.2e-70 236.2 0.0 2.6e-70 236.0 0.0 1.0 1 0 0 1 1 1 1 Casein kinase II regulatory subunit HigB-like_toxin PF05015.13 EDO15662.1 - 0.15 12.5 0.1 0.26 11.7 0.1 1.4 1 0 0 1 1 1 0 RelE-like toxin of type II toxin-antitoxin system HigB HAGH_C PF16123.5 EDO15663.1 - 8e-18 64.7 0.0 1.3e-17 64.1 0.0 1.3 1 0 0 1 1 1 1 Hydroxyacylglutathione hydrolase C-terminus Lactamase_B PF00753.27 EDO15663.1 - 1e-12 48.5 0.0 1.2e-11 45.0 0.0 2.2 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EDO15663.1 - 0.00094 18.7 0.3 0.0017 17.9 0.3 1.6 1 1 0 1 1 1 1 Beta-lactamase superfamily domain RNase_PH PF01138.21 EDO15664.1 - 1.2e-20 74.4 0.0 2e-20 73.6 0.0 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 EDO15664.1 - 4.8e-12 45.7 0.6 4.2e-11 42.7 0.1 2.2 2 0 0 2 2 2 1 3' exoribonuclease family, domain 2 TRAM_LAG1_CLN8 PF03798.16 EDO15666.1 - 1e-34 120.1 22.6 1e-34 120.1 22.6 2.1 2 0 0 2 2 2 1 TLC domain DUF3611 PF12263.8 EDO15666.1 - 0.00091 19.2 1.1 0.0022 17.9 1.1 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF3611) Ctr PF04145.15 EDO15666.1 - 1.9 9.1 6.3 0.61 10.7 0.3 2.6 2 1 0 2 2 2 0 Ctr copper transporter family TRAM_LAG1_CLN8 PF03798.16 EDO15667.1 - 8.1e-34 117.1 16.0 8.1e-34 117.1 16.0 1.9 2 0 0 2 2 2 1 TLC domain Peptidase_M48_N PF16491.5 EDO15668.1 - 3.3e-58 196.6 9.7 3.3e-58 196.6 9.7 2.2 2 0 0 2 2 2 1 CAAX prenyl protease N-terminal, five membrane helices Peptidase_M48 PF01435.18 EDO15668.1 - 1.1e-41 142.8 0.1 2.5e-41 141.6 0.1 1.6 1 1 0 1 1 1 1 Peptidase family M48 DUF2268 PF10026.9 EDO15668.1 - 0.0074 15.9 0.1 0.013 15.0 0.1 1.3 1 0 0 1 1 1 1 Predicted Zn-dependent protease (DUF2268) Ilm1 PF10311.9 EDO15669.1 - 5e-13 49.0 14.1 1.6e-10 40.9 14.1 2.1 1 1 0 1 1 1 1 Increased loss of mitochondrial DNA protein 1 CDC45 PF02724.14 EDO15669.1 - 0.0037 15.6 0.3 0.0038 15.6 0.3 1.1 1 0 0 1 1 1 1 CDC45-like protein JmjC PF02373.22 EDO15670.1 - 9.3e-37 126.0 0.6 2.6e-36 124.5 0.6 1.8 1 0 0 1 1 1 1 JmjC domain, hydroxylase JmjN PF02375.17 EDO15670.1 - 1.7e-08 34.3 0.0 1.7e-08 34.3 0.0 2.8 3 0 0 3 3 3 1 jmjN domain PHD PF00628.29 EDO15670.1 - 1.7e-06 27.8 19.9 5.5e-06 26.2 11.1 2.5 2 0 0 2 2 2 2 PHD-finger PHD_2 PF13831.6 EDO15670.1 - 0.076 12.6 17.0 0.024 14.2 6.2 2.8 2 0 0 2 2 2 0 PHD-finger Zf_RING PF16744.5 EDO15670.1 - 0.12 12.5 8.3 0.24 11.6 7.1 2.2 2 0 0 2 2 2 0 KIAA1045 RING finger Swi6_N PF18530.1 EDO15670.1 - 0.7 10.1 4.7 6.4 7.0 0.0 3.7 3 0 0 3 3 3 0 Swi6 N-terminal domain RXT2_N PF08595.11 EDO15670.1 - 0.82 9.7 13.6 0.15 12.1 2.6 3.4 3 0 0 3 3 3 0 RXT2-like, N-terminal PHD_4 PF16866.5 EDO15670.1 - 0.97 9.6 19.1 0.84 9.8 11.7 2.8 2 1 0 2 2 2 0 PHD-finger TF_Zn_Ribbon PF08271.12 EDO15670.1 - 5.9 6.5 13.4 0.088 12.3 2.1 3.0 3 0 0 3 3 3 0 TFIIB zinc-binding zf-HC5HC2H PF13771.6 EDO15670.1 - 6.4 7.1 10.8 1.1 9.5 5.1 2.5 2 0 0 2 2 2 0 PHD-like zinc-binding domain ATP-synt_ab PF00006.25 EDO15671.1 - 5.6e-62 209.2 0.0 8.3e-62 208.6 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 EDO15671.1 - 3.9e-22 78.6 1.5 3.9e-22 78.6 1.5 2.1 2 0 0 2 2 2 1 ATP synthase alpha/beta family, beta-barrel domain ATPase PF06745.13 EDO15671.1 - 0.0043 16.4 0.2 0.0074 15.7 0.2 1.4 1 0 0 1 1 1 1 KaiC NB-ARC PF00931.22 EDO15671.1 - 0.0099 15.1 0.6 0.078 12.1 0.1 2.1 2 0 0 2 2 2 1 NB-ARC domain NACHT PF05729.12 EDO15671.1 - 0.037 14.0 0.2 0.12 12.3 0.0 1.9 2 0 0 2 2 2 0 NACHT domain RsgA_GTPase PF03193.16 EDO15671.1 - 0.04 13.8 0.1 0.1 12.5 0.1 1.6 1 0 0 1 1 1 0 RsgA GTPase AAA_19 PF13245.6 EDO15671.1 - 0.047 14.0 2.1 0.47 10.8 0.1 2.7 3 0 0 3 3 3 0 AAA domain T3SS_ATPase_C PF18269.1 EDO15671.1 - 0.051 13.4 0.7 0.3 11.0 0.7 2.1 1 1 0 1 1 1 0 T3SS EscN ATPase C-terminal domain AAA PF00004.29 EDO15671.1 - 0.071 13.5 0.0 0.82 10.1 0.0 2.4 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EDO15671.1 - 0.092 13.1 0.7 0.29 11.5 0.2 2.1 2 1 0 2 2 2 0 AAA ATPase domain RNA_helicase PF00910.22 EDO15671.1 - 0.13 12.6 0.0 0.27 11.6 0.0 1.5 1 0 0 1 1 1 0 RNA helicase TsaE PF02367.17 EDO15671.1 - 0.19 11.7 0.2 0.51 10.3 0.1 1.7 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Pox_A32 PF04665.12 EDO15671.1 - 0.24 10.8 0.1 0.5 9.8 0.1 1.4 1 0 0 1 1 1 0 Poxvirus A32 protein Yuri_gagarin PF15934.5 EDO15672.1 - 0.039 13.8 1.4 0.76 9.6 0.1 2.3 2 0 0 2 2 2 0 Yuri gagarin DnaGprimase_HBD PF16730.5 EDO15672.1 - 0.19 11.8 1.3 1.2 9.2 0.1 2.6 2 0 0 2 2 2 0 DnaG-primase C-terminal, helicase-binding domain Ribosomal_S7 PF00177.21 EDO15673.1 - 5e-37 126.8 1.9 8e-37 126.2 1.9 1.3 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e DUF5591 PF17884.1 EDO15673.1 - 0.0075 16.1 0.0 0.012 15.5 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF5591) MFS_1 PF07690.16 EDO15674.1 - 1.2e-18 67.2 15.1 2.8e-10 39.7 19.5 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Zn_clus PF00172.18 EDO15675.1 - 2e-07 31.0 10.2 3.9e-07 30.1 10.2 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF5570 PF17731.1 EDO15675.1 - 0.016 15.3 0.0 0.041 14.0 0.0 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5570) eIF2_C PF09173.11 EDO15676.1 - 1.7e-34 117.9 0.5 4.2e-34 116.6 0.5 1.7 1 0 0 1 1 1 1 Initiation factor eIF2 gamma, C terminal GTP_EFTU PF00009.27 EDO15676.1 - 3.4e-23 82.2 0.3 3.6e-22 78.9 0.3 2.3 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 EDO15676.1 - 6.6e-12 45.6 0.5 2.9e-11 43.6 0.5 2.2 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EDO15676.1 - 0.0025 17.9 0.0 0.0055 16.8 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EDO15676.1 - 0.0051 16.7 0.1 0.083 12.8 0.0 2.2 2 0 0 2 2 2 1 RsgA GTPase MMR_HSR1_Xtn PF16897.5 EDO15676.1 - 0.038 14.0 0.1 0.1 12.6 0.1 1.7 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain ORC4_C PF14629.6 EDO15677.1 - 1.4e-36 125.9 2.2 2.5e-36 125.1 2.2 1.4 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 4 C-terminus AAA_16 PF13191.6 EDO15677.1 - 1.2e-06 29.0 0.0 2.4e-06 28.0 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EDO15677.1 - 6.7e-05 23.2 0.1 0.00013 22.2 0.1 1.5 1 0 0 1 1 1 1 AAA domain Ca_bind_SSO6904 PF18249.1 EDO15677.1 - 0.065 13.6 2.7 0.44 10.9 0.2 3.5 3 0 0 3 3 3 0 Calcium binding protein SSO6904 AAA_14 PF13173.6 EDO15677.1 - 0.59 10.2 5.2 0.67 10.0 1.3 3.0 2 1 0 2 2 2 0 AAA domain Kelch_4 PF13418.6 EDO15678.1 - 0.1 12.6 0.4 35 4.5 0.1 3.5 3 0 0 3 3 3 0 Galactose oxidase, central domain Kelch_2 PF07646.15 EDO15678.1 - 4.5 7.4 4.8 2.4 8.3 0.2 3.0 4 0 0 4 4 4 0 Kelch motif Ras PF00071.22 EDO15679.1 - 2.3e-55 186.6 0.0 2.7e-55 186.4 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EDO15679.1 - 3.3e-21 75.7 0.0 5.1e-21 75.1 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EDO15679.1 - 1.1e-06 28.3 0.0 1.5e-06 27.8 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 EDO15679.1 - 0.067 12.6 0.0 0.098 12.1 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 EDO15679.1 - 0.14 11.5 0.0 0.16 11.3 0.0 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region PAPS_reduct PF01507.19 EDO15680.1 - 2.6e-40 138.3 0.0 3.3e-40 137.9 0.0 1.2 1 0 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family Med10 PF09748.9 EDO15681.1 - 1.1e-39 135.2 0.7 1.3e-39 134.9 0.7 1.0 1 0 0 1 1 1 1 Transcription factor subunit Med10 of Mediator complex AIP3 PF03915.13 EDO15681.1 - 0.019 14.1 1.0 0.022 13.8 1.0 1.1 1 0 0 1 1 1 0 Actin interacting protein 3 APOBEC3 PF18771.1 EDO15681.1 - 0.025 14.7 0.0 0.031 14.4 0.0 1.3 1 0 0 1 1 1 0 APOBEC3 NPV_P10 PF05531.12 EDO15681.1 - 0.24 11.9 3.9 0.39 11.2 0.3 2.5 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein WD40 PF00400.32 EDO15682.1 - 3.7e-07 30.7 0.0 0.072 14.0 0.0 3.4 3 0 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDO15682.1 - 7.9e-07 29.3 0.0 0.11 12.9 0.0 3.8 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain SPX PF03105.19 EDO15682.1 - 1.7 8.4 23.4 0.22 11.4 15.3 2.2 2 0 0 2 2 2 0 SPX domain Arrestin_C PF02752.22 EDO15683.1 - 3e-26 92.5 0.2 6.4e-25 88.2 0.0 2.6 2 0 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 EDO15683.1 - 2.8e-07 30.7 0.0 7.5e-06 26.1 0.0 2.4 1 1 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain LDB19 PF13002.7 EDO15683.1 - 0.0017 18.1 0.3 0.005 16.6 0.0 1.9 2 0 0 2 2 2 1 Arrestin_N terminal like Peptidase_C25_C PF03785.14 EDO15684.1 - 0.13 12.1 0.3 0.39 10.6 0.0 1.9 2 0 0 2 2 2 0 Peptidase family C25, C terminal ig-like domain RRM_1 PF00076.22 EDO15685.1 - 2.5e-41 139.3 14.7 1.1e-17 63.5 0.7 5.3 4 1 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EDO15685.1 - 1.4e-05 24.7 2.7 0.28 10.8 0.1 3.6 2 1 1 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EDO15685.1 - 6.8e-05 22.9 1.2 0.15 12.2 0.0 4.2 3 2 0 3 3 3 1 RNA recognition motif RRM_3 PF08777.11 EDO15685.1 - 0.0039 17.2 7.2 0.04 13.9 0.0 3.7 4 0 0 4 4 4 2 RNA binding motif RRM_Rrp7 PF17799.1 EDO15685.1 - 0.0039 17.0 22.5 0.17 11.7 0.4 5.0 3 2 1 5 5 5 3 Rrp7 RRM-like N-terminal domain Limkain-b1 PF11608.8 EDO15685.1 - 0.0069 16.4 0.2 9.1 6.4 0.0 3.8 3 0 0 3 3 3 1 Limkain b1 Stathmin PF00836.19 EDO15685.1 - 0.029 14.3 2.8 0.087 12.8 2.8 1.8 1 0 0 1 1 1 0 Stathmin family Nup35_RRM_2 PF14605.6 EDO15685.1 - 0.12 12.4 0.2 16 5.5 0.1 3.3 3 0 0 3 3 3 0 Nup53/35/40-type RNA recognition motif Ysc84 PF04366.12 EDO15686.1 - 1.2e-41 141.4 0.1 1.9e-41 140.8 0.1 1.3 1 0 0 1 1 1 1 Las17-binding protein actin regulator SH3_1 PF00018.28 EDO15686.1 - 2e-16 59.3 0.1 3.9e-16 58.4 0.1 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EDO15686.1 - 5.7e-12 45.3 0.0 1.4e-11 44.0 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EDO15686.1 - 1e-10 41.1 0.0 2.6e-10 39.8 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain DUF3104 PF11302.8 EDO15686.1 - 0.17 11.6 0.0 0.44 10.3 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3104) ProRS-C_1 PF09180.11 EDO15687.1 - 3.6e-27 94.4 2.2 1e-26 92.9 2.2 1.8 1 0 0 1 1 1 1 Prolyl-tRNA synthetase, C-terminal HGTP_anticodon PF03129.20 EDO15687.1 - 3.5e-20 71.9 0.4 1.5e-19 69.9 0.3 2.2 2 0 0 2 2 2 1 Anticodon binding domain tRNA-synt_2b PF00587.25 EDO15687.1 - 6.5e-15 55.6 0.0 1.2e-14 54.6 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) tRNA_edit PF04073.15 EDO15687.1 - 0.015 15.4 0.1 0.028 14.5 0.1 1.4 1 0 0 1 1 1 0 Aminoacyl-tRNA editing domain SipA_VBS PF17985.1 EDO15687.1 - 0.058 13.3 0.7 3.7 7.6 0.0 2.6 2 0 0 2 2 2 0 SipA vinculin binding site Acetyltransf_13 PF13880.6 EDO15688.1 - 2.4e-22 78.7 0.0 7e-22 77.2 0.0 1.7 2 0 0 2 2 2 1 ESCO1/2 acetyl-transferase zf-C2H2_3 PF13878.6 EDO15688.1 - 1.7e-13 50.2 0.7 3.5e-13 49.1 0.7 1.6 1 0 0 1 1 1 1 zinc-finger of acetyl-transferase ESCO Acetyltransf_1 PF00583.25 EDO15688.1 - 0.00074 19.7 0.0 0.0013 19.0 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EDO15688.1 - 0.01 16.3 0.0 0.026 14.9 0.0 1.7 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain DSPn PF14671.6 EDO15689.1 - 8.1e-46 156.0 0.1 3.1e-45 154.1 0.1 1.9 2 0 0 2 2 2 1 Dual specificity protein phosphatase, N-terminal half DSPc PF00782.20 EDO15689.1 - 5e-24 84.6 0.0 4e-23 81.7 0.0 2.2 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EDO15689.1 - 6.6e-05 22.6 0.7 0.00023 20.8 0.0 2.1 2 0 0 2 2 2 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 EDO15689.1 - 0.0032 17.6 0.0 0.0096 16.1 0.0 1.9 2 0 0 2 2 2 1 Inositol hexakisphosphate CDKN3 PF05706.12 EDO15689.1 - 0.0046 16.6 0.1 0.0095 15.6 0.1 1.4 1 0 0 1 1 1 1 Cyclin-dependent kinase inhibitor 3 (CDKN3) Y_phosphatase3 PF13350.6 EDO15689.1 - 0.099 12.6 0.0 0.19 11.7 0.0 1.4 1 0 0 1 1 1 0 Tyrosine phosphatase family CSRNP_N PF16019.5 EDO15689.1 - 0.77 9.6 3.4 1.4 8.8 3.4 1.5 1 1 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus IFT57 PF10498.9 EDO15690.1 - 0.0049 15.9 13.5 0.0049 15.9 13.5 4.1 2 2 2 4 4 4 1 Intra-flagellar transport protein 57 MAD PF05557.13 EDO15690.1 - 0.25 9.6 70.9 0.013 13.9 31.5 3.1 2 1 1 3 3 3 0 Mitotic checkpoint protein WEMBL PF05701.11 EDO15690.1 - 2.6 6.6 55.3 0.11 11.2 23.4 2.4 2 1 1 3 3 3 0 Weak chloroplast movement under blue light DUF730 PF05325.11 EDO15690.1 - 8.7 6.4 14.6 0.44 10.6 1.9 3.5 2 1 0 2 2 2 0 Protein of unknown function (DUF730) MDFI PF15316.6 EDO15691.1 - 0.13 12.3 3.2 0.22 11.6 3.2 1.3 1 0 0 1 1 1 0 MyoD family inhibitor KcnmB2_inactiv PF09303.10 EDO15691.1 - 6.1 6.7 7.9 0.33 10.8 0.7 2.6 2 0 0 2 2 2 0 KCNMB2, ball and chain domain DDR_swiveling PF18427.1 EDO15693.1 - 1.7e-05 24.9 14.1 6.1 6.8 0.1 7.1 5 3 2 7 7 7 4 DD-reactivating factor swiveling domain CPSF73-100_C PF11718.8 EDO15693.1 - 0.72 9.4 11.9 6.7 6.2 0.6 4.1 1 1 3 4 4 4 0 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term DDR_swiveling PF18427.1 EDO15694.1 - 0.0018 18.4 8.6 5.3 7.0 0.1 5.1 4 2 2 6 6 6 3 DD-reactivating factor swiveling domain CPSF73-100_C PF11718.8 EDO15694.1 - 0.83 9.2 3.2 4.7 6.7 1.3 2.6 1 1 2 3 3 3 0 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term KdpC PF02669.15 EDO15694.1 - 2.3 8.0 11.8 2.3 8.0 7.5 2.8 1 1 2 3 3 3 0 K+-transporting ATPase, c chain DDR_swiveling PF18427.1 EDO15695.1 - 1.4e-05 25.1 16.4 5.6 7.0 0.1 7.5 5 4 1 6 6 6 4 DD-reactivating factor swiveling domain CPSF73-100_C PF11718.8 EDO15695.1 - 0.0025 17.4 14.9 0.32 10.5 1.0 5.1 1 1 4 5 5 5 2 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term Enterotoxin_ST PF02048.16 EDO15695.1 - 8.7 6.9 28.4 70 4.0 0.2 8.1 2 2 7 9 9 9 0 Heat-stable enterotoxin ST Flocculin PF00624.18 EDO15696.1 - 1.8e-137 447.3 434.1 2.3e-13 50.1 11.9 25.0 23 0 0 23 23 23 21 Flocculin repeat Flocculin PF00624.18 EDO15697.1 - 1.6e-40 137.1 247.4 4.9e-09 36.3 8.1 12.8 12 1 0 12 12 12 10 Flocculin repeat NAD_binding_6 PF08030.12 EDO15698.1 - 7.5e-27 94.4 0.0 1.3e-26 93.6 0.0 1.4 1 0 0 1 1 1 1 Ferric reductase NAD binding domain Ferric_reduct PF01794.19 EDO15698.1 - 8.3e-24 84.1 18.1 8.3e-24 84.1 18.1 3.0 3 0 0 3 3 3 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.12 EDO15698.1 - 3.4e-22 78.6 0.0 1e-21 77.0 0.0 1.8 1 0 0 1 1 1 1 FAD-binding domain Aminotran_4 PF01063.19 EDO15699.1 - 1.7e-36 126.2 0.0 2.3e-36 125.8 0.0 1.2 1 0 0 1 1 1 1 Amino-transferase class IV SET PF00856.28 EDO15701.1 - 6.7e-18 65.7 0.0 1.1e-17 64.9 0.0 1.4 1 0 0 1 1 1 1 SET domain zf-FLZ PF04570.14 EDO15701.1 - 0.21 11.1 3.2 3.9 7.0 0.5 3.0 3 0 0 3 3 3 0 zinc-finger of the FCS-type, C2-C2 Pkinase PF00069.25 EDO15702.1 - 2.6e-65 220.4 0.0 3.6e-65 219.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO15702.1 - 1.6e-31 109.6 0.0 2.4e-31 109.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.24 EDO15702.1 - 9.2e-08 32.7 0.8 9.2e-08 32.7 0.8 2.3 2 0 0 2 2 2 1 Protein kinase C terminal domain Kinase-like PF14531.6 EDO15702.1 - 4.2e-07 29.6 0.1 1.3e-06 27.9 0.0 1.7 2 0 0 2 2 2 1 Kinase-like C2 PF00168.30 EDO15702.1 - 4.9e-05 23.6 0.2 0.0088 16.3 0.0 3.0 3 0 0 3 3 3 1 C2 domain Haspin_kinase PF12330.8 EDO15702.1 - 6.7e-05 22.0 0.3 0.00014 20.9 0.3 1.5 1 0 0 1 1 1 1 Haspin like kinase domain Glyco_hydro_47 PF01532.20 EDO15703.1 - 1.4e-113 380.2 0.0 1.7e-113 379.9 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Mgm101p PF06420.12 EDO15705.1 - 1e-82 275.8 0.0 1.2e-82 275.5 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial genome maintenance MGM101 PMT PF02366.18 EDO15706.1 - 4.7e-81 272.0 21.3 4.7e-81 272.0 21.3 2.1 2 0 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 EDO15706.1 - 9e-65 218.0 8.7 9e-65 218.0 8.7 3.4 3 0 0 3 3 3 2 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 EDO15706.1 - 1.2e-21 77.4 2.5 2.2e-21 76.6 2.5 1.4 1 0 0 1 1 1 1 MIR domain TMEM126 PF07114.11 EDO15706.1 - 0.011 15.2 0.0 0.026 13.9 0.0 1.6 1 0 0 1 1 1 0 Transmembrane protein 126 PHO4 PF01384.20 EDO15706.1 - 0.088 11.8 2.0 0.17 10.9 0.3 2.0 2 0 0 2 2 2 0 Phosphate transporter family DUF3671 PF12420.8 EDO15706.1 - 0.19 11.8 6.0 0.81 9.8 0.3 2.7 2 0 0 2 2 2 0 Protein of unknown function DUF4743 PF15916.5 EDO15707.1 - 4.6e-08 33.0 0.2 9.6e-08 32.0 0.1 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF4743) NUDIX PF00293.28 EDO15707.1 - 1.1e-07 32.0 0.0 2.5e-07 30.8 0.0 1.5 1 0 0 1 1 1 1 NUDIX domain DHHA2 PF02833.14 EDO15708.1 - 9.9e-31 106.8 0.2 3.3e-30 105.1 0.1 1.8 2 0 0 2 2 2 1 DHHA2 domain DHH PF01368.20 EDO15708.1 - 2.1e-11 43.9 0.0 3.7e-11 43.1 0.0 1.4 1 0 0 1 1 1 1 DHH family HECT_2 PF09814.9 EDO15709.1 - 8.6e-60 202.6 0.4 9.7e-60 202.4 0.4 1.0 1 0 0 1 1 1 1 HECT-like Ubiquitin-conjugating enzyme (E2)-binding MitMem_reg PF13012.6 EDO15711.1 - 0.053 13.9 1.2 7.1 7.1 0.2 3.0 2 0 0 2 2 2 0 Maintenance of mitochondrial structure and function Xpo1 PF08389.12 EDO15711.1 - 0.17 11.9 6.3 0.43 10.6 0.2 3.6 2 1 1 3 3 3 0 Exportin 1-like protein Chalcone_2 PF16035.5 EDO15712.1 - 5.8e-67 225.4 0.0 7.3e-67 225.1 0.0 1.1 1 0 0 1 1 1 1 Chalcone isomerase like Chalcone_3 PF16036.5 EDO15712.1 - 0.00021 21.5 2.9 0.29 11.2 0.2 2.2 1 1 1 2 2 2 2 Chalcone isomerase-like Tti2 PF10521.9 EDO15713.1 - 5.9e-63 213.0 0.6 8.2e-63 212.6 0.6 1.2 1 0 0 1 1 1 1 Tti2 family ATP-synt_J PF04911.12 EDO15714.1 - 7.9e-25 86.2 0.1 9e-25 86.0 0.1 1.0 1 0 0 1 1 1 1 ATP synthase j chain A_deaminase_N PF08451.11 EDO15715.1 - 0.056 13.7 0.9 0.056 13.7 0.9 2.5 2 1 1 3 3 3 0 Adenosine/AMP deaminase N-terminal DUF4497 PF14924.6 EDO15715.1 - 0.059 13.9 2.9 0.72 10.3 0.1 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF4497) RNA_polI_A14 PF08203.11 EDO15715.1 - 1.2 9.8 3.9 6.1 7.6 3.7 2.4 1 1 0 1 1 1 0 Yeast RNA polymerase I subunit RPA14 Myb_DNA-bind_5 PF13873.6 EDO15716.1 - 0.048 13.7 0.1 12 6.1 0.0 2.6 2 0 0 2 2 2 0 Myb/SANT-like DNA-binding domain DUF5321 PF17254.2 EDO15716.1 - 0.092 12.2 0.1 0.25 10.8 0.0 1.8 1 1 0 1 1 1 0 Family of unknown function (DUF5321) FliN_N PF16973.5 EDO15716.1 - 0.13 12.2 0.2 0.33 10.8 0.1 1.7 1 1 0 1 1 1 0 Flagellar motor switch protein FliN N-terminal ARPC4 PF05856.12 EDO15717.1 - 4.2e-73 244.4 5.0 4.7e-73 244.3 5.0 1.0 1 0 0 1 1 1 1 ARP2/3 complex 20 kDa subunit (ARPC4) FF PF01846.19 EDO15718.1 - 2.2e-35 120.6 22.4 1.2e-11 44.6 0.7 6.6 6 1 1 7 7 7 3 FF domain WW PF00397.26 EDO15718.1 - 3.5e-21 75.0 7.9 3e-11 43.2 1.9 2.5 2 0 0 2 2 2 2 WW domain PQQ PF01011.21 EDO15718.1 - 2.6e-06 27.1 0.2 0.0031 17.4 0.0 2.5 2 0 0 2 2 2 2 PQQ enzyme repeat Glyco_hyd_101C PF17451.2 EDO15718.1 - 4e-06 27.1 7.2 0.0048 17.2 0.3 3.6 2 1 1 3 3 3 2 Glycosyl hydrolase 101 beta sandwich domain PQQ_2 PF13360.6 EDO15718.1 - 0.0024 17.5 0.0 0.007 16.0 0.0 1.5 1 1 0 1 1 1 1 PQQ-like domain ParBc PF02195.18 EDO15720.1 - 1.6e-15 57.2 0.0 1.8e-15 57.0 0.0 1.1 1 0 0 1 1 1 1 ParB-like nuclease domain Ldh_1_C PF02866.18 EDO15721.1 - 1.1e-53 181.6 0.1 1.9e-53 180.8 0.1 1.4 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.23 EDO15721.1 - 2.3e-44 150.9 0.1 4e-44 150.1 0.1 1.4 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain 3Beta_HSD PF01073.19 EDO15721.1 - 0.0013 17.8 0.0 0.0019 17.2 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Glyco_hydro_4 PF02056.16 EDO15721.1 - 0.095 12.2 1.0 1.1 8.8 0.1 2.6 2 1 1 3 3 3 0 Family 4 glycosyl hydrolase CbiG_N PF11760.8 EDO15721.1 - 0.12 12.4 0.9 0.55 10.3 0.3 2.2 2 0 0 2 2 2 0 Cobalamin synthesis G N-terminal Ank_2 PF12796.7 EDO15722.1 - 2.7e-21 75.9 0.1 1.1e-07 32.3 0.0 3.5 2 1 2 4 4 4 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EDO15722.1 - 2.3e-19 69.5 2.6 2.6e-07 31.0 0.2 3.8 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.30 EDO15722.1 - 8.2e-14 51.3 5.8 0.019 15.4 0.1 4.9 5 0 0 5 5 5 4 Ankyrin repeat Ank_3 PF13606.6 EDO15722.1 - 1.6e-11 43.3 4.8 0.013 15.9 0.0 5.2 5 0 0 5 5 5 3 Ankyrin repeat Ank_5 PF13857.6 EDO15722.1 - 2.6e-09 37.2 0.4 0.0042 17.4 0.0 4.0 2 2 2 4 4 4 2 Ankyrin repeats (many copies) TUG-UBL1 PF11470.8 EDO15723.1 - 1.9e-18 66.4 0.1 8.2e-18 64.4 0.1 2.2 1 0 0 1 1 1 1 TUG ubiquitin-like domain UBX PF00789.20 EDO15723.1 - 1.4e-12 47.6 0.1 4.9e-12 45.9 0.1 2.0 2 0 0 2 2 2 1 UBX domain SASP PF00269.20 EDO15723.1 - 0.043 13.8 0.0 0.11 12.6 0.0 1.6 1 0 0 1 1 1 0 Small, acid-soluble spore proteins, alpha/beta type PPR_2 PF13041.6 EDO15724.1 - 0.0018 18.4 4.7 5.2 7.4 0.0 5.1 5 0 0 5 5 5 2 PPR repeat family PPR PF01535.20 EDO15724.1 - 0.29 11.5 1.0 31 5.1 0.0 4.5 5 0 0 5 5 5 0 PPR repeat EF1G PF00647.19 EDO15725.1 - 2.3e-48 162.7 0.2 4.3e-48 161.8 0.2 1.5 1 0 0 1 1 1 1 Elongation factor 1 gamma, conserved domain GST_N PF02798.20 EDO15725.1 - 2e-12 47.3 0.0 5.4e-12 45.9 0.0 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EDO15725.1 - 1.8e-11 44.1 2.0 7.8e-11 42.1 0.0 2.4 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EDO15725.1 - 0.00029 21.0 1.1 0.00062 19.9 0.0 2.2 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EDO15725.1 - 0.0011 18.9 0.1 0.0027 17.7 0.1 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EDO15725.1 - 0.0023 18.3 0.0 0.0043 17.4 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain AEP1 PF17049.5 EDO15726.1 - 4.7e-126 421.1 21.9 5.4e-126 420.9 21.9 1.0 1 0 0 1 1 1 1 ATPase expression protein 1 RNase_HII PF01351.18 EDO15726.1 - 0.071 12.9 0.1 0.15 11.9 0.1 1.5 1 0 0 1 1 1 0 Ribonuclease HII SUR7 PF06687.12 EDO15727.1 - 8.2e-22 77.9 17.9 1.1e-21 77.5 17.9 1.1 1 0 0 1 1 1 1 SUR7/PalI family DUF3996 PF13161.6 EDO15727.1 - 0.053 13.2 0.9 0.42 10.3 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3996) Herpes_LMP1 PF05297.11 EDO15727.1 - 1.3 8.2 5.6 1.9 7.6 5.6 1.2 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) FA_desaturase PF00487.24 EDO15727.1 - 1.8 8.3 8.3 3.3 7.5 8.3 1.5 1 1 0 1 1 1 0 Fatty acid desaturase HA2 PF04408.23 EDO15728.1 - 6e-19 68.3 0.0 6e-19 68.3 0.0 1.9 2 0 0 2 2 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 EDO15728.1 - 1.4e-13 51.0 0.0 4.1e-13 49.5 0.0 1.9 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 EDO15728.1 - 2.2e-11 44.1 0.2 2.3e-10 40.8 0.0 2.6 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 EDO15728.1 - 1.6e-10 41.0 0.2 3.4e-10 40.0 0.2 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 EDO15728.1 - 8.3e-06 26.1 0.4 4.5e-05 23.7 0.4 2.2 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EDO15728.1 - 0.00078 19.8 0.1 0.0018 18.6 0.1 1.6 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EDO15728.1 - 0.0017 18.1 0.0 0.0029 17.3 0.0 1.3 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.27 EDO15728.1 - 0.0048 17.4 0.3 0.016 15.7 0.3 1.9 1 1 0 1 1 1 1 ABC transporter AAA_23 PF13476.6 EDO15728.1 - 0.0053 17.3 0.0 0.0053 17.3 0.0 2.6 2 1 1 3 3 1 1 AAA domain AAA_29 PF13555.6 EDO15728.1 - 0.0073 16.0 0.0 0.024 14.4 0.0 1.9 1 0 0 1 1 1 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EDO15728.1 - 0.0074 16.2 0.0 0.016 15.1 0.0 1.5 1 0 0 1 1 1 1 RsgA GTPase AAA_7 PF12775.7 EDO15728.1 - 0.023 14.2 0.0 0.052 13.1 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region PhoH PF02562.16 EDO15728.1 - 0.029 13.8 0.0 0.1 12.0 0.0 1.9 2 0 0 2 2 2 0 PhoH-like protein AAA_24 PF13479.6 EDO15728.1 - 0.05 13.3 0.0 0.13 12.0 0.0 1.7 1 1 0 1 1 1 0 AAA domain APC_rep PF18797.1 EDO15728.1 - 0.052 14.5 0.0 0.14 13.1 0.0 1.7 1 0 0 1 1 1 0 Adenomatous polyposis coli (APC) repeat Flavi_DEAD PF07652.14 EDO15728.1 - 0.061 13.3 0.0 0.12 12.4 0.0 1.5 1 0 0 1 1 1 0 Flavivirus DEAD domain AAA_25 PF13481.6 EDO15728.1 - 0.072 12.7 0.0 0.18 11.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain SRP54 PF00448.22 EDO15728.1 - 0.087 12.4 0.1 0.73 9.4 0.1 2.4 2 1 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_14 PF13173.6 EDO15728.1 - 0.49 10.4 4.3 1.1 9.3 0.6 2.8 2 1 0 2 2 1 0 AAA domain DUF87 PF01935.17 EDO15728.1 - 1.4 9.0 4.9 2.7 8.0 0.0 2.5 1 1 1 2 2 2 0 Helicase HerA, central domain ArgJ PF01960.18 EDO15729.1 - 6.7e-142 472.7 6.8 7.6e-142 472.5 6.8 1.0 1 0 0 1 1 1 1 ArgJ family Cu-oxidase_2 PF07731.14 EDO15730.1 - 2e-45 153.9 4.7 5e-39 133.2 2.0 2.8 2 1 0 2 2 2 2 Multicopper oxidase Cu-oxidase_3 PF07732.15 EDO15730.1 - 2.4e-40 137.3 7.8 4.9e-38 129.8 0.2 3.4 4 0 0 4 4 4 2 Multicopper oxidase Cu-oxidase PF00394.22 EDO15730.1 - 1.6e-39 135.6 4.4 2.7e-37 128.3 1.0 3.1 3 0 0 3 3 3 2 Multicopper oxidase Cupredoxin_1 PF13473.6 EDO15730.1 - 0.0016 18.6 0.0 0.25 11.5 0.0 3.4 3 1 0 3 3 3 1 Cupredoxin-like domain C1q PF00386.21 EDO15730.1 - 0.078 13.2 0.0 0.19 12.0 0.0 1.6 1 0 0 1 1 1 0 C1q domain RRM_1 PF00076.22 EDO15731.1 - 0.019 14.8 0.0 0.064 13.1 0.0 2.0 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SpoIIID PF12116.8 EDO15732.1 - 0.23 11.6 2.9 0.53 10.4 2.9 1.6 1 0 0 1 1 1 0 Stage III sporulation protein D GAF_2 PF13185.6 EDO15733.1 - 5e-10 39.8 0.0 1.2e-09 38.5 0.0 1.6 1 1 0 1 1 1 1 GAF domain GAF PF01590.26 EDO15733.1 - 3.7e-05 24.4 0.0 5.3e-05 23.9 0.0 1.4 1 1 0 1 1 1 1 GAF domain GAF_3 PF13492.6 EDO15733.1 - 0.015 15.7 0.0 0.029 14.7 0.0 1.5 1 0 0 1 1 1 0 GAF domain Npun_R1517 PF18068.1 EDO15733.1 - 0.07 13.5 0.1 0.16 12.3 0.1 1.6 1 0 0 1 1 1 0 Npun R1517 Swi3 PF07962.12 EDO15734.1 - 4.5e-24 84.2 0.1 7.1e-24 83.6 0.1 1.3 1 0 0 1 1 1 1 Replication Fork Protection Component Swi3 Nucleoporin_FG PF13634.6 EDO15736.1 - 6e-51 171.2 316.2 1.6e-12 48.0 38.7 10.1 2 1 9 11 11 11 9 Nucleoporin FG repeat region Nucleoporin2 PF04096.14 EDO15736.1 - 1.6e-38 132.1 0.0 3.6e-38 131.0 0.0 1.5 1 0 0 1 1 1 1 Nucleoporin autopeptidase PWWP PF00855.17 EDO15737.1 - 5.5e-22 78.0 0.0 5.5e-22 78.0 0.0 2.8 2 2 0 2 2 2 1 PWWP domain SRF-TF PF00319.18 EDO15738.1 - 3.6e-21 74.4 0.2 5.5e-21 73.8 0.2 1.3 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) SRF-TF PF00319.18 EDO15739.1 - 1.7e-18 65.8 0.3 2.7e-18 65.2 0.3 1.4 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) ELH PF02323.15 EDO15739.1 - 0.033 13.5 0.0 0.039 13.3 0.0 1.1 1 0 0 1 1 1 0 Egg-laying hormone precursor Clat_adaptor_s PF01217.20 EDO15740.1 - 1.5e-49 167.6 3.9 1.7e-49 167.4 3.9 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Proteasome_A_N PF10584.9 EDO15742.1 - 0.089 12.5 0.0 0.26 11.0 0.0 1.8 1 0 0 1 1 1 0 Proteasome subunit A N-terminal signature Urb2 PF10441.9 EDO15743.1 - 1.8e-54 184.8 1.5 1.8e-54 184.8 1.5 3.2 3 1 0 3 3 3 1 Urb2/Npa2 family Chor_lyase PF04345.13 EDO15743.1 - 0.0076 15.9 0.8 0.44 10.2 0.0 3.1 3 0 0 3 3 3 1 Chorismate lyase CSTF2_hinge PF14327.6 EDO15743.1 - 0.064 13.7 0.5 0.064 13.7 0.5 2.4 2 0 0 2 2 2 0 Hinge domain of cleavage stimulation factor subunit 2 SAM_2 PF07647.17 EDO15744.1 - 5.3e-09 36.1 0.1 2.7e-08 33.8 0.0 2.2 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 EDO15744.1 - 0.00018 21.9 0.0 0.00044 20.6 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PDEase_I PF00233.19 EDO15745.1 - 2.8e-51 174.6 3.5 2.8e-51 174.6 3.5 1.5 2 0 0 2 2 2 1 3'5'-cyclic nucleotide phosphodiesterase HD PF01966.22 EDO15745.1 - 0.081 13.2 0.1 0.17 12.1 0.1 1.5 1 0 0 1 1 1 0 HD domain BolA PF01722.18 EDO15746.1 - 9.9e-24 83.4 0.1 1.2e-23 83.1 0.1 1.2 1 0 0 1 1 1 1 BolA-like protein BolA PF01722.18 EDO15747.1 - 6e-13 48.9 0.0 2.9e-12 46.7 0.0 2.0 2 1 0 2 2 2 1 BolA-like protein NUC153 PF08159.12 EDO15747.1 - 0.092 12.6 0.0 0.19 11.6 0.0 1.5 1 0 0 1 1 1 0 NUC153 domain Mto2_bdg PF12808.7 EDO15748.1 - 1.3e-05 25.4 9.6 1.3e-05 25.4 9.6 3.4 4 0 0 4 4 4 1 Micro-tubular organiser Mto1 C-term Mto2-binding region RNR_N PF08343.10 EDO15748.1 - 0.0041 17.1 0.7 0.0041 17.1 0.7 3.1 3 1 0 3 3 3 1 Ribonucleotide reductase N-terminal bZIP_2 PF07716.15 EDO15748.1 - 0.015 15.4 6.7 0.015 15.4 6.7 7.1 8 1 0 8 8 8 0 Basic region leucine zipper DUF924 PF06041.11 EDO15748.1 - 9.3 6.3 9.6 0.25 11.4 0.9 2.7 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF924) EF_assoc_1 PF08355.12 EDO15749.1 - 3.4e-27 93.9 1.0 6.1e-27 93.0 1.0 1.5 1 0 0 1 1 1 1 EF hand associated EF_assoc_2 PF08356.12 EDO15749.1 - 2.3e-26 91.6 0.0 9.6e-26 89.6 0.0 2.1 2 0 0 2 2 2 1 EF hand associated Ras PF00071.22 EDO15749.1 - 7.2e-21 74.5 0.0 3.3e-10 39.8 0.0 2.4 2 0 0 2 2 2 2 Ras family Roc PF08477.13 EDO15749.1 - 1.2e-13 51.3 0.0 3.3e-06 27.3 0.0 2.7 2 1 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase EF-hand_1 PF00036.32 EDO15749.1 - 2.8e-09 35.9 0.9 7.3e-05 22.0 0.5 3.1 2 0 0 2 2 2 2 EF hand MMR_HSR1 PF01926.23 EDO15749.1 - 3.9e-09 36.6 0.0 0.0027 17.7 0.0 3.0 2 1 0 2 2 2 2 50S ribosome-binding GTPase EF-hand_6 PF13405.6 EDO15749.1 - 4e-07 29.5 1.4 0.00046 19.9 0.2 2.9 2 1 0 2 2 2 2 EF-hand domain Dynamin_N PF00350.23 EDO15749.1 - 3.2e-06 27.3 0.1 0.018 15.1 0.0 2.4 2 0 0 2 2 2 2 Dynamin family EF-hand_7 PF13499.6 EDO15749.1 - 1.9e-05 25.0 0.4 0.32 11.5 0.0 2.9 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 EDO15749.1 - 3.4e-05 23.1 2.5 0.00067 19.0 0.9 2.9 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.6 EDO15749.1 - 0.00011 21.9 0.6 0.36 10.7 0.3 2.7 2 0 0 2 2 2 2 EF-hand domain pair RsgA_GTPase PF03193.16 EDO15749.1 - 0.00067 19.6 0.1 0.015 15.2 0.0 3.1 5 0 0 5 5 3 1 RsgA GTPase AAA_29 PF13555.6 EDO15749.1 - 0.00068 19.3 0.0 1.1 9.1 0.1 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain Arf PF00025.21 EDO15749.1 - 0.0012 18.3 0.0 0.0054 16.2 0.0 1.9 2 0 0 2 2 2 1 ADP-ribosylation factor family AAA_22 PF13401.6 EDO15749.1 - 0.0013 19.0 0.0 0.32 11.3 0.0 2.7 2 1 0 2 2 2 1 AAA domain ABC_tran PF00005.27 EDO15749.1 - 0.0017 18.9 0.0 0.25 11.9 0.0 2.4 2 0 0 2 2 2 1 ABC transporter AAA_16 PF13191.6 EDO15749.1 - 0.0023 18.3 0.0 3.2 8.1 0.0 2.8 3 0 0 3 3 2 1 AAA ATPase domain AAA_24 PF13479.6 EDO15749.1 - 0.0034 17.1 0.0 2.2 8.0 0.0 2.3 2 0 0 2 2 2 2 AAA domain GTP_EFTU PF00009.27 EDO15749.1 - 0.0045 16.6 0.0 5 6.6 0.0 3.4 4 0 0 4 4 4 1 Elongation factor Tu GTP binding domain AAA_18 PF13238.6 EDO15749.1 - 0.0074 16.8 0.0 0.95 10.0 0.0 2.9 2 1 0 2 2 2 1 AAA domain TniB PF05621.11 EDO15749.1 - 0.012 15.0 0.0 0.56 9.6 0.0 2.2 2 0 0 2 2 2 0 Bacterial TniB protein RNA_helicase PF00910.22 EDO15749.1 - 0.013 15.9 0.0 2.6 8.5 0.0 2.7 2 0 0 2 2 2 0 RNA helicase AAA_23 PF13476.6 EDO15749.1 - 0.023 15.2 0.4 1.2 9.6 0.1 2.6 3 0 0 3 3 2 0 AAA domain Septin PF00735.18 EDO15749.1 - 0.026 13.8 0.0 0.25 10.6 0.0 2.1 2 0 0 2 2 2 0 Septin ATPase_2 PF01637.18 EDO15749.1 - 0.051 13.5 0.1 2.5 8.0 0.0 2.5 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea FeoB_N PF02421.18 EDO15749.1 - 0.072 12.6 0.3 6.4 6.3 0.0 3.0 3 0 0 3 3 3 0 Ferrous iron transport protein B AAA_7 PF12775.7 EDO15749.1 - 0.084 12.4 0.0 0.72 9.3 0.0 2.3 2 1 1 3 3 3 0 P-loop containing dynein motor region AAA_15 PF13175.6 EDO15749.1 - 0.13 11.9 0.0 12 5.5 0.0 2.3 2 1 0 2 2 2 0 AAA ATPase domain DUF815 PF05673.13 EDO15749.1 - 0.13 11.4 0.1 2.7 7.1 0.1 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF815) FtsK_SpoIIIE PF01580.18 EDO15749.1 - 0.21 10.9 0.0 24 4.2 0.1 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family DLH PF01738.18 EDO15750.1 - 9.7e-23 80.9 0.0 1.2e-22 80.5 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family STb_secrete PF09075.10 EDO15750.1 - 0.14 12.3 1.4 0.28 11.3 1.4 1.5 1 0 0 1 1 1 0 Heat-stable enterotoxin B, secretory TRP PF06011.12 EDO15751.1 - 2.7e-155 517.3 34.7 4.2e-155 516.7 34.7 1.3 1 0 0 1 1 1 1 Transient receptor potential (TRP) ion channel TRP_N PF14558.6 EDO15751.1 - 3e-41 141.1 3.2 5.2e-41 140.3 3.2 1.4 1 0 0 1 1 1 1 ML-like domain CH PF00307.31 EDO15752.1 - 2e-13 50.5 0.3 2.9e-13 49.9 0.3 1.3 1 0 0 1 1 1 1 Calponin homology (CH) domain Peroxin-22 PF12827.7 EDO15753.1 - 1.6e-24 86.0 0.0 2.1e-24 85.6 0.0 1.1 1 0 0 1 1 1 1 Peroxisomal biogenesis protein family Rad1 PF02144.16 EDO15754.1 - 1.8e-72 243.7 1.3 2.4e-72 243.3 1.3 1.1 1 0 0 1 1 1 1 Repair protein Rad1/Rec1/Rad17 FAM91_C PF14648.6 EDO15754.1 - 0.057 12.3 0.1 0.084 11.7 0.1 1.2 1 0 0 1 1 1 0 FAM91 C-terminus Ribosomal_L7Ae PF01248.26 EDO15755.1 - 5.1e-22 77.4 0.5 6.4e-22 77.1 0.5 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family DUF1269 PF06897.12 EDO15755.1 - 0.04 14.2 0.2 0.095 13.0 0.2 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1269) GDI PF00996.18 EDO15756.1 - 3.8e-46 157.5 0.0 1.7e-45 155.3 0.0 1.8 1 1 0 1 1 1 1 GDP dissociation inhibitor Kelch_4 PF13418.6 EDO15757.1 - 1.5e-07 31.3 8.2 0.031 14.3 0.3 5.7 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_5 PF13854.6 EDO15757.1 - 1.4e-05 25.0 12.8 0.24 11.4 0.0 5.5 6 0 0 6 6 6 3 Kelch motif Kelch_6 PF13964.6 EDO15757.1 - 2.4e-05 24.5 9.6 0.9 9.9 0.6 5.7 6 0 0 6 6 6 2 Kelch motif Kelch_2 PF07646.15 EDO15757.1 - 0.0013 18.6 11.2 1.2 9.2 1.0 5.9 6 0 0 6 6 6 2 Kelch motif Kelch_3 PF13415.6 EDO15757.1 - 0.0074 16.6 1.7 0.98 9.8 0.1 4.3 4 1 0 4 4 4 1 Galactose oxidase, central domain Kelch_1 PF01344.25 EDO15757.1 - 0.057 13.0 11.0 3 7.5 1.1 4.6 5 0 0 5 5 5 0 Kelch motif Calreticulin PF00262.18 EDO15758.1 - 1.8e-129 431.8 10.6 2.3e-129 431.5 10.6 1.1 1 0 0 1 1 1 1 Calreticulin family Alb1 PF09135.11 EDO15759.1 - 1e-26 93.8 8.8 1e-26 93.8 8.8 2.0 2 1 0 2 2 2 1 Alb1 ADH_N PF08240.12 EDO15760.1 - 2.1e-32 111.2 2.2 4e-32 110.4 2.2 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EDO15760.1 - 8.5e-22 77.5 0.0 1.8e-21 76.5 0.0 1.6 2 0 0 2 2 2 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 EDO15760.1 - 3.4e-05 23.4 0.0 4.9e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus Pyr_redox_3 PF13738.6 EDO15760.1 - 0.0045 16.3 0.0 0.011 15.0 0.1 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EDO15760.1 - 0.018 14.3 0.0 0.029 13.6 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EDO15760.1 - 0.02 15.4 0.0 0.043 14.4 0.0 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_7 PF13241.6 EDO15760.1 - 0.035 14.5 0.0 0.064 13.7 0.0 1.5 1 0 0 1 1 1 0 Putative NAD(P)-binding Prim_Zn_Ribbon PF08273.12 EDO15760.1 - 0.045 14.0 0.1 0.13 12.5 0.1 1.8 1 0 0 1 1 1 0 Zinc-binding domain of primase-helicase RuvB_C PF05491.13 EDO15760.1 - 0.076 12.9 0.1 0.53 10.2 0.0 2.1 2 0 0 2 2 2 0 RuvB C-terminal winged helix domain 2-Hacid_dh_C PF02826.19 EDO15760.1 - 0.11 11.9 0.0 0.36 10.2 0.0 1.8 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain DAO PF01266.24 EDO15760.1 - 1.1 8.8 4.1 1.6 8.3 2.6 1.9 2 1 0 2 2 2 0 FAD dependent oxidoreductase Zn_clus PF00172.18 EDO15761.1 - 1.2e-08 35.0 13.1 2e-08 34.2 13.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Sugar_tr PF00083.24 EDO15762.1 - 5.4e-161 536.4 35.0 6.2e-161 536.3 35.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDO15762.1 - 8.4e-29 100.6 36.6 5.7e-25 88.0 23.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Flocculin PF00624.18 EDO15763.1 - 3.6e-57 190.3 334.6 6.3e-11 42.3 11.3 89.1 43 10 46 89 89 89 21 Flocculin repeat DUF5092 PF17010.5 EDO15763.1 - 2.9 7.8 37.3 58 3.5 0.1 15.8 3 2 5 14 14 14 0 Domain of unknown function (DUF5092) Cofilin_ADF PF00241.20 EDO15764.1 - 6.3e-41 139.0 0.0 8.1e-41 138.6 0.0 1.1 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein ABC_tran PF00005.27 EDO15765.1 - 0.0053 17.3 0.5 0.011 16.3 0.3 1.6 2 0 0 2 2 2 1 ABC transporter SMC_N PF02463.19 EDO15765.1 - 0.072 12.5 0.8 0.087 12.3 0.8 1.1 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain Phosphodiest PF01663.22 EDO15766.1 - 2e-13 50.7 0.4 3e-13 50.1 0.4 1.2 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Metalloenzyme PF01676.18 EDO15766.1 - 0.17 11.2 2.7 0.33 10.3 2.7 1.3 1 0 0 1 1 1 0 Metalloenzyme superfamily Peptidase_M24 PF00557.24 EDO15767.1 - 4.4e-43 147.4 0.0 7.3e-43 146.7 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 Creatinase_N_2 PF16189.5 EDO15767.1 - 1.7e-40 138.8 1.1 4e-40 137.6 0.3 2.1 3 0 0 3 3 3 1 Creatinase/Prolidase N-terminal domain Peptidase_M24_C PF16188.5 EDO15767.1 - 1e-20 73.6 1.8 4.2e-20 71.6 0.2 2.6 2 0 0 2 2 2 1 C-terminal region of peptidase_M24 Creatinase_N PF01321.18 EDO15767.1 - 8.4e-11 42.6 0.0 3.9e-08 34.0 0.0 2.5 2 0 0 2 2 2 2 Creatinase/Prolidase N-terminal domain p47_phox_C PF08944.11 EDO15767.1 - 3.1 7.3 4.3 1.5 8.3 1.4 1.9 2 0 0 2 2 2 0 NADPH oxidase subunit p47Phox, C terminal domain MFS_1 PF07690.16 EDO15768.1 - 7.3e-39 133.7 35.8 7.3e-39 133.7 35.8 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EDO15768.1 - 9.8e-08 31.3 31.3 1.2e-06 27.7 31.0 2.6 1 1 0 1 1 1 1 Sugar (and other) transporter AAA_2 PF07724.14 EDO15769.1 - 7.3e-47 159.7 0.1 7.9e-46 156.3 0.0 2.7 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_lid_9 PF17871.1 EDO15769.1 - 1.1e-27 96.0 0.8 1.1e-27 96.0 0.8 3.5 2 1 1 3 3 2 1 AAA lid domain ClpB_D2-small PF10431.9 EDO15769.1 - 1.9e-23 82.3 1.7 8.9e-23 80.2 1.7 2.3 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA PF00004.29 EDO15769.1 - 5.1e-22 78.7 3.4 1.7e-13 51.1 0.0 3.2 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) Clp_N PF02861.20 EDO15769.1 - 7.5e-15 54.8 4.6 2.8e-09 36.9 1.1 3.2 2 0 0 2 2 2 2 Clp amino terminal domain, pathogenicity island component AAA_5 PF07728.14 EDO15769.1 - 1.4e-14 54.2 0.0 6e-08 32.8 0.0 3.2 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 EDO15769.1 - 5.6e-10 39.2 0.1 2.4e-07 30.6 0.0 2.8 2 1 0 2 2 2 1 Sigma-54 interaction domain AAA_16 PF13191.6 EDO15769.1 - 1.2e-07 32.2 8.2 0.00017 22.0 0.0 4.9 5 1 0 5 5 5 2 AAA ATPase domain AAA_14 PF13173.6 EDO15769.1 - 6.5e-06 26.2 0.3 0.25 11.4 0.0 3.1 3 0 0 3 3 2 2 AAA domain AAA_22 PF13401.6 EDO15769.1 - 1.2e-05 25.7 3.3 0.11 12.8 0.1 4.2 3 2 0 3 3 2 2 AAA domain AAA_24 PF13479.6 EDO15769.1 - 4.7e-05 23.2 0.0 0.028 14.1 0.0 2.7 2 0 0 2 2 2 1 AAA domain TIP49 PF06068.13 EDO15769.1 - 0.00013 21.4 7.2 0.13 11.4 0.0 3.7 4 0 0 4 4 4 2 TIP49 P-loop domain AAA_3 PF07726.11 EDO15769.1 - 0.00023 21.1 0.0 0.6 10.0 0.0 2.9 2 1 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) Torsin PF06309.11 EDO15769.1 - 0.00028 21.0 0.0 0.0043 17.2 0.0 2.6 2 0 0 2 2 2 1 Torsin AAA_7 PF12775.7 EDO15769.1 - 0.00032 20.2 0.0 0.19 11.3 0.0 2.5 2 0 0 2 2 2 1 P-loop containing dynein motor region NACHT PF05729.12 EDO15769.1 - 0.00059 19.8 0.1 0.8 9.6 0.0 3.1 3 0 0 3 3 2 1 NACHT domain Mg_chelatase PF01078.21 EDO15769.1 - 0.001 18.5 0.0 0.58 9.5 0.0 3.3 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI Zeta_toxin PF06414.12 EDO15769.1 - 0.0024 17.2 0.2 0.23 10.7 0.0 3.3 3 0 0 3 3 3 1 Zeta toxin AAA_33 PF13671.6 EDO15769.1 - 0.0038 17.4 0.1 0.62 10.2 0.0 3.5 3 0 0 3 3 2 1 AAA domain IstB_IS21 PF01695.17 EDO15769.1 - 0.012 15.4 0.0 1.7 8.3 0.0 2.8 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_19 PF13245.6 EDO15769.1 - 0.015 15.6 0.0 0.72 10.2 0.0 3.1 2 1 0 2 2 2 0 AAA domain TsaE PF02367.17 EDO15769.1 - 0.017 15.1 0.0 1.3 9.0 0.0 2.5 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE PEPCK_ATP PF01293.20 EDO15769.1 - 0.033 12.9 0.0 0.077 11.6 0.0 1.5 1 0 0 1 1 1 0 Phosphoenolpyruvate carboxykinase NTPase_1 PF03266.15 EDO15769.1 - 0.059 13.3 0.0 6.7 6.6 0.0 3.2 2 0 0 2 2 2 0 NTPase Roc PF08477.13 EDO15769.1 - 0.064 13.5 0.0 16 5.7 0.0 2.8 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase RNA_helicase PF00910.22 EDO15769.1 - 0.086 13.2 0.0 22 5.5 0.0 3.2 3 0 0 3 3 3 0 RNA helicase ABC_tran PF00005.27 EDO15769.1 - 0.23 12.0 6.4 0.56 10.7 0.4 3.7 3 1 0 3 3 3 0 ABC transporter ATPase_2 PF01637.18 EDO15769.1 - 1.6 8.6 15.3 2.7 7.9 0.1 4.6 5 2 2 7 7 4 0 ATPase domain predominantly from Archaea AAA_18 PF13238.6 EDO15769.1 - 8 7.0 8.0 6.3 7.4 0.0 4.2 5 0 0 5 5 4 0 AAA domain RRM_1 PF00076.22 EDO15770.1 - 6.8e-29 99.5 2.1 4.3e-15 55.3 0.0 3.8 3 1 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EDO15770.1 - 1.5e-05 24.9 0.3 0.25 11.4 0.0 3.1 3 0 0 3 3 3 2 Nup53/35/40-type RNA recognition motif RRM_5 PF13893.6 EDO15770.1 - 0.0015 18.2 0.1 0.0048 16.5 0.0 1.8 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EDO15770.1 - 0.019 14.8 0.0 8.3 6.4 0.0 2.5 2 0 0 2 2 2 0 Occluded RNA-recognition motif Ribonuc_red_sm PF00268.21 EDO15771.1 - 3.7e-112 374.4 0.8 5e-112 373.9 0.8 1.2 1 0 0 1 1 1 1 Ribonucleotide reductase, small chain DUF4744 PF15918.5 EDO15771.1 - 0.097 13.5 0.0 0.28 12.1 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4744) zf-Tim10_DDP PF02953.15 EDO15772.1 - 1.2e-19 69.7 1.7 1.7e-19 69.2 1.7 1.2 1 0 0 1 1 1 1 Tim10/DDP family zinc finger PRK PF00485.18 EDO15772.1 - 0.16 11.7 0.2 0.23 11.1 0.2 1.3 1 1 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family zf-UBR PF02207.20 EDO15773.1 - 1.5e-12 47.4 12.3 5.3e-12 45.7 12.3 2.0 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) tRNA-synt_1b PF00579.25 EDO15774.1 - 5.4e-78 262.3 0.0 7.3e-78 261.9 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) TFIIF_alpha PF05793.12 EDO15775.1 - 3.3e-09 35.9 5.0 3.3e-09 35.9 5.0 2.2 1 1 1 2 2 2 2 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) DUF383 PF04063.14 EDO15776.1 - 5e-64 215.5 0.9 5e-63 212.2 0.3 2.6 3 0 0 3 3 3 1 Domain of unknown function (DUF383) DUF384 PF04064.13 EDO15776.1 - 1e-20 73.3 0.1 3.6e-20 71.6 0.0 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF384) PapB PF03333.13 EDO15776.1 - 0.13 12.3 0.4 0.34 11.0 0.1 1.8 2 0 0 2 2 2 0 Adhesin biosynthesis transcription regulatory protein HEAT_2 PF13646.6 EDO15776.1 - 0.16 12.4 0.0 0.5 10.8 0.0 1.9 1 0 0 1 1 1 0 HEAT repeats Rab5ip PF07019.12 EDO15777.1 - 2e-22 79.5 7.4 2.5e-22 79.2 7.4 1.1 1 0 0 1 1 1 1 Rab5-interacting protein (Rab5ip) PUF PF00806.19 EDO15778.1 - 1.1e-53 175.9 13.6 8.7e-09 34.6 0.1 8.7 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat CPL PF08144.11 EDO15778.1 - 0.0081 16.5 8.0 1.9 8.9 0.4 5.3 3 1 4 7 7 7 1 CPL (NUC119) domain Mnd1 PF03962.15 EDO15778.1 - 0.15 12.3 0.7 6.5 7.1 0.0 3.2 3 0 0 3 3 3 0 Mnd1 HTH domain Abhydro_lipase PF04083.16 EDO15779.1 - 4.6e-15 54.9 0.0 1.1e-14 53.7 0.0 1.7 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region Abhydrolase_1 PF00561.20 EDO15779.1 - 2.1e-08 34.1 0.1 6.9e-08 32.4 0.0 1.9 2 0 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EDO15779.1 - 0.00026 20.3 0.0 0.00055 19.3 0.0 1.6 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Lipase_2 PF01674.18 EDO15779.1 - 0.024 14.2 0.0 0.05 13.1 0.0 1.6 1 0 0 1 1 1 0 Lipase (class 2) NIF PF03031.18 EDO15780.1 - 4.9e-52 175.8 0.4 7.3e-52 175.3 0.4 1.3 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase Menin PF05053.13 EDO15780.1 - 0.71 8.2 5.5 0.95 7.7 5.5 1.2 1 0 0 1 1 1 0 Menin FA_desaturase PF00487.24 EDO15781.1 - 4.7e-19 69.2 16.5 4.7e-19 69.2 16.5 1.8 1 1 1 2 2 2 1 Fatty acid desaturase Cyt-b5 PF00173.28 EDO15781.1 - 3.9e-13 49.3 0.0 9e-13 48.2 0.0 1.6 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain GAIN PF16489.5 EDO15782.1 - 0.02 14.3 6.7 0.031 13.7 6.7 1.3 1 0 0 1 1 1 0 GPCR-Autoproteolysis INducing (GAIN) domain FapA PF03961.13 EDO15782.1 - 0.064 11.9 12.3 0.07 11.7 9.5 1.9 1 1 1 2 2 2 0 Flagellar Assembly Protein A TFR_dimer PF04253.15 EDO15782.1 - 1.6 8.9 7.3 4.6 7.4 3.2 2.3 1 1 1 2 2 2 0 Transferrin receptor-like dimerisation domain IZUMO PF15005.6 EDO15782.1 - 2.6 8.6 8.3 0.4 11.2 2.0 2.1 1 1 1 2 2 2 0 Izumo sperm-egg fusion, Ig domain-associated PCRF PF03462.18 EDO15782.1 - 3 7.7 5.9 2.2 8.1 2.0 2.1 1 1 1 2 2 2 0 PCRF domain MapZ_EC1 PF18041.1 EDO15782.1 - 3.6 7.8 12.9 1.2 9.4 6.5 2.9 2 1 1 3 3 3 0 MapZ extracellular domain 1 Cornichon PF03311.14 EDO15783.1 - 3.5e-49 166.2 9.7 4.1e-49 166.0 9.7 1.0 1 0 0 1 1 1 1 Cornichon protein Ribosomal_S18 PF01084.20 EDO15784.1 - 2e-17 63.1 0.0 3.4e-17 62.4 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S18 BCDHK_Adom3 PF10436.9 EDO15785.1 - 1e-23 84.0 1.2 1.6e-23 83.4 1.2 1.3 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 EDO15785.1 - 1.1e-10 42.0 0.0 2.8e-10 40.7 0.0 1.7 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 EDO15785.1 - 0.002 18.0 0.0 0.0035 17.2 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase BAR_2 PF10455.9 EDO15786.1 - 1.6e-85 286.7 18.1 1.6e-85 286.7 18.1 3.0 3 1 0 3 3 3 1 Bin/amphiphysin/Rvs domain for vesicular trafficking BAR PF03114.18 EDO15786.1 - 1.6e-10 41.1 9.1 1.2e-09 38.1 9.1 2.3 1 1 0 1 1 1 1 BAR domain DUF2891 PF11199.8 EDO15786.1 - 0.048 12.6 0.4 0.077 11.9 0.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2891) HTH_WhiA PF02650.14 EDO15786.1 - 0.083 13.2 1.1 0.4 11.0 0.1 2.5 2 0 0 2 2 2 0 WhiA C-terminal HTH domain Syntaxin_2 PF14523.6 EDO15786.1 - 0.72 10.3 11.6 2.7 8.4 3.4 3.6 2 2 0 2 2 2 0 Syntaxin-like protein AGA2 PF17366.2 EDO15787.1 - 3.5e-26 90.7 6.1 4.2e-26 90.4 6.1 1.1 1 0 0 1 1 1 1 A-agglutinin-binding subunit Aga2 RNA_pol_Rpb1_5 PF04998.17 EDO15790.1 - 1.2e-96 323.3 1.3 1e-95 320.2 0.1 2.8 2 1 0 2 2 2 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 EDO15790.1 - 2.9e-70 235.8 0.2 6.2e-70 234.7 0.2 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.18 EDO15790.1 - 2.3e-41 141.3 3.0 1.5e-39 135.4 0.0 4.1 4 0 0 4 4 4 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_1 PF04997.12 EDO15790.1 - 2.3e-26 92.9 4.2 5.8e-26 91.6 1.2 3.0 2 1 0 2 2 2 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_4 PF05000.17 EDO15790.1 - 1.1e-23 83.2 0.1 1.1e-23 83.2 0.1 3.5 3 0 0 3 3 3 1 RNA polymerase Rpb1, domain 4 RPA43_OB PF17875.1 EDO15791.1 - 4.3e-30 104.9 0.4 9.7e-30 103.7 0.4 1.6 1 0 0 1 1 1 1 RPA43 OB domain in RNA Pol I SHS2_Rpb7-N PF03876.17 EDO15791.1 - 9.9e-14 51.5 0.0 2.1e-13 50.4 0.0 1.6 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 SWIRM PF04433.17 EDO15792.1 - 1.5e-08 34.9 0.0 3.5e-08 33.7 0.0 1.6 1 0 0 1 1 1 1 SWIRM domain Glyco_transf_24 PF18404.1 EDO15793.1 - 4.6e-38 131.2 0.1 9.6e-38 130.1 0.1 1.5 1 0 0 1 1 1 1 Glucosyltransferase 24 Thioredoxin_14 PF18402.1 EDO15793.1 - 8.3e-22 78.4 4.3 4.3e-21 76.0 1.2 3.3 3 1 0 3 3 3 1 Thioredoxin-like domain Thioredoxin_13 PF18401.1 EDO15793.1 - 1.2e-06 28.5 1.4 4.5e-06 26.6 1.4 2.0 1 0 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_12 PF18400.1 EDO15793.1 - 1.1e-05 25.4 0.0 2.3e-05 24.4 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin-like domain ApoA-II PF04711.13 EDO15793.1 - 0.04 14.1 0.1 9.3 6.5 0.0 2.9 2 0 0 2 2 2 0 Apolipoprotein A-II (ApoA-II) tRNA-synt_2c PF01411.19 EDO15794.1 - 4.4e-228 758.3 0.0 6.9e-228 757.6 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class II (A) tRNA_SAD PF07973.14 EDO15794.1 - 5e-19 68.1 0.2 1.2e-18 66.9 0.2 1.7 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain DHHA1 PF02272.19 EDO15794.1 - 2.7e-12 47.3 5.0 6.2e-12 46.1 5.0 1.6 1 0 0 1 1 1 1 DHHA1 domain Halogen_Hydrol PF10112.9 EDO15794.1 - 0.64 10.0 6.2 12 5.9 1.8 2.8 3 0 0 3 3 3 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein Synaptobrevin PF00957.21 EDO15795.1 - 8.3e-32 108.8 0.5 9.4e-32 108.7 0.5 1.0 1 0 0 1 1 1 1 Synaptobrevin Prominin PF05478.11 EDO15795.1 - 0.056 11.4 0.1 0.075 11.0 0.1 1.3 1 0 0 1 1 1 0 Prominin DUF3671 PF12420.8 EDO15795.1 - 0.16 12.1 1.2 0.22 11.6 1.2 1.3 1 1 0 1 1 1 0 Protein of unknown function UPF0258 PF06789.12 EDO15795.1 - 0.22 11.6 1.5 0.31 11.1 1.5 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0258) Hph PF13694.6 EDO15796.1 - 2.4e-09 37.7 20.3 2.4e-09 37.7 20.3 2.9 3 0 0 3 3 3 1 Sec63/Sec62 complex-interacting family FliJ PF02050.16 EDO15796.1 - 0.0028 17.9 2.4 0.0072 16.6 2.4 1.6 1 0 0 1 1 1 1 Flagellar FliJ protein RasGAP_C PF03836.15 EDO15796.1 - 4 7.6 15.9 0.22 11.7 4.9 3.1 1 1 2 3 3 3 0 RasGAP C-terminus RPW8 PF05659.11 EDO15796.1 - 4.7 6.9 10.7 5.9 6.6 4.1 2.7 1 1 2 3 3 3 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 PhoLip_ATPase_C PF16212.5 EDO15797.1 - 2e-84 283.2 27.3 2e-84 283.2 27.3 2.4 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EDO15797.1 - 1.3e-23 82.5 6.3 1.3e-23 82.5 6.3 2.3 3 0 0 3 3 3 1 Phospholipid-translocating ATPase N-terminal Cation_ATPase PF13246.6 EDO15797.1 - 1.8e-10 40.8 0.0 6.2e-10 39.0 0.0 1.9 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 EDO15797.1 - 3.7e-10 40.4 0.3 2.3e-05 24.8 0.1 3.1 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 EDO15797.1 - 1.4e-06 28.0 0.0 3.7e-06 26.6 0.0 1.7 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase_3 PF08282.12 EDO15797.1 - 0.0017 18.1 0.1 0.02 14.7 0.1 2.4 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase DUF2204 PF09970.9 EDO15797.1 - 0.016 14.8 0.5 0.078 12.6 0.0 2.3 2 0 0 2 2 2 0 Nucleotidyl transferase of unknown function (DUF2204) LDB19 PF13002.7 EDO15798.1 - 3.3e-72 242.3 0.7 5.2e-72 241.6 0.7 1.3 1 0 0 1 1 1 1 Arrestin_N terminal like Arrestin_N PF00339.29 EDO15798.1 - 0.00015 21.8 0.1 0.00047 20.2 0.1 1.8 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain Spo0M PF07070.11 EDO15798.1 - 0.011 15.3 0.4 0.23 11.0 0.0 2.9 3 0 0 3 3 3 0 SpoOM protein DUF2616 PF11077.8 EDO15798.1 - 0.053 13.2 1.7 2.8 7.6 0.0 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF2616) PMT PF02366.18 EDO15799.1 - 9.2e-92 307.0 20.1 9.2e-92 307.0 20.1 2.2 2 1 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 EDO15799.1 - 2.2e-61 206.9 12.2 2.2e-61 206.9 12.2 2.7 2 1 1 3 3 3 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 EDO15799.1 - 5.6e-29 101.3 0.7 1.1e-28 100.3 0.7 1.4 1 0 0 1 1 1 1 MIR domain Nucleoside_tran PF01733.18 EDO15800.1 - 8.5e-55 186.3 19.8 1.8e-37 129.4 5.6 2.3 1 1 1 2 2 2 2 Nucleoside transporter Exo_endo_phos PF03372.23 EDO15801.1 - 4.6e-23 82.0 0.0 9.4e-23 80.9 0.0 1.6 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family LRR_8 PF13855.6 EDO15801.1 - 4e-15 55.3 28.1 7.4e-09 35.2 6.2 2.9 1 1 2 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 EDO15801.1 - 7.5e-09 35.7 13.4 3.9e-06 27.1 5.0 5.4 5 1 0 5 5 5 2 Leucine Rich repeats (2 copies) RCC1 PF00415.18 EDO15802.1 - 4.7e-25 88.0 14.9 4.3e-06 27.3 0.4 6.3 6 0 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EDO15802.1 - 5.8e-20 70.6 21.9 5.4e-10 38.8 3.3 6.0 6 0 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat PAN_3 PF08277.12 EDO15802.1 - 0.045 13.5 0.0 0.1 12.4 0.0 1.5 1 0 0 1 1 1 0 PAN-like domain DUF4213 PF13938.6 EDO15802.1 - 9.6 6.5 5.8 31 4.9 0.2 3.4 3 1 1 4 4 4 0 Putative heavy-metal chelation tRNA-synt_1b PF00579.25 EDO15803.1 - 0.012 14.9 3.8 0.017 14.5 3.8 1.2 1 0 0 1 1 1 0 tRNA synthetases class I (W and Y) Ste5_C PF12194.8 EDO15803.1 - 0.039 13.9 3.4 0.043 13.8 2.8 1.3 1 1 0 1 1 1 0 Protein kinase Fus3-binding SNF2_N PF00176.23 EDO15804.1 - 2.4e-59 200.9 0.1 4.1e-59 200.1 0.1 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EDO15804.1 - 2.7e-21 76.0 0.2 6.4e-18 65.1 0.1 3.3 3 0 0 3 3 3 2 Helicase conserved C-terminal domain ResIII PF04851.15 EDO15804.1 - 1.7e-11 44.4 1.0 5.7e-11 42.7 0.0 2.5 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 EDO15804.1 - 1.1e-06 28.1 0.1 3.4e-06 26.5 0.1 1.8 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase HDA2-3 PF11496.8 EDO15804.1 - 8.4 5.5 21.0 0.024 13.8 4.6 3.6 3 1 0 3 3 3 0 Class II histone deacetylase complex subunits 2 and 3 GSH_synth_ATP PF03917.17 EDO15805.1 - 2.8e-130 434.5 0.0 3.2e-130 434.2 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic glutathione synthase, ATP binding domain GSH_synthase PF03199.15 EDO15805.1 - 3.6e-33 114.1 0.0 7e-33 113.2 0.0 1.5 1 0 0 1 1 1 1 Eukaryotic glutathione synthase DUF3192 PF11399.8 EDO15805.1 - 0.036 14.0 0.0 0.071 13.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3192) EI24 PF07264.11 EDO15806.1 - 0.014 15.6 12.3 0.026 14.8 12.3 1.5 1 1 0 1 1 1 0 Etoposide-induced protein 2.4 (EI24) Pkinase PF00069.25 EDO15807.1 - 1.3e-63 214.9 0.0 3.4e-63 213.5 0.0 1.8 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO15807.1 - 1.2e-24 87.0 0.0 2.2e-24 86.1 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDO15807.1 - 3.7e-08 33.0 0.0 7.1e-08 32.1 0.0 1.5 1 0 0 1 1 1 1 Kinase-like PAS_9 PF13426.7 EDO15807.1 - 0.0017 18.5 0.1 0.094 13.0 0.0 3.0 2 0 0 2 2 2 1 PAS domain Kdo PF06293.14 EDO15807.1 - 0.0039 16.6 0.0 0.0089 15.4 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EDO15807.1 - 0.035 14.0 0.0 0.086 12.7 0.0 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family HEAT PF02985.22 EDO15808.1 - 5.6e-35 116.4 14.5 0.0076 16.4 0.0 12.5 13 0 0 13 13 13 9 HEAT repeat HEAT_2 PF13646.6 EDO15808.1 - 8.4e-30 103.0 0.7 8.5e-09 35.7 0.0 7.4 4 3 3 7 7 7 7 HEAT repeats Vac14_Fab1_bd PF12755.7 EDO15808.1 - 1.3e-12 48.2 5.0 0.1 13.2 0.0 7.7 4 2 4 8 8 8 5 Vacuolar 14 Fab1-binding region Cnd1 PF12717.7 EDO15808.1 - 5.2e-10 39.6 18.8 0.0034 17.4 3.5 6.5 2 1 6 8 8 8 4 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 EDO15808.1 - 1.5e-06 28.5 6.7 1.7 9.2 0.1 7.1 5 2 2 7 7 7 1 HEAT-like repeat TAF6_C PF07571.13 EDO15808.1 - 0.00061 20.1 0.1 2.5 8.5 0.0 4.5 4 1 0 4 4 4 1 TAF6 C-terminal HEAT repeat domain RTP1_C1 PF10363.9 EDO15808.1 - 0.00068 19.8 8.9 8.3 6.6 0.0 5.5 4 2 0 5 5 5 1 Required for nuclear transport of RNA pol II C-terminus 1 API5 PF05918.11 EDO15808.1 - 0.0008 18.3 6.4 0.051 12.4 0.1 3.7 2 1 1 4 4 4 2 Apoptosis inhibitory protein 5 (API5) Arm PF00514.23 EDO15808.1 - 0.079 13.0 1.7 2.7 8.1 0.1 4.3 6 0 0 6 6 6 0 Armadillo/beta-catenin-like repeat Trp_Tyr_perm PF03222.13 EDO15808.1 - 0.1 11.6 0.0 0.22 10.5 0.0 1.5 1 0 0 1 1 1 0 Tryptophan/tyrosine permease family HEPN_Apea PF18739.1 EDO15808.1 - 0.18 12.3 1.5 0.77 10.2 0.0 2.8 2 2 0 2 2 2 0 Apea-like HEPN Importin_rep_4 PF18808.1 EDO15808.1 - 2.3 8.5 5.2 35 4.8 0.0 4.2 5 0 0 5 5 5 0 Importin repeat HhH-GPD PF00730.25 EDO15809.1 - 3.7e-23 82.1 0.0 6.4e-23 81.3 0.0 1.4 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 EDO15809.1 - 1.6e-05 24.5 0.1 5.3e-05 22.9 0.0 2.0 2 0 0 2 2 2 1 Helix-hairpin-helix motif RRM_1 PF00076.22 EDO15810.1 - 3.1e-17 62.1 4.7 6.8e-15 54.7 0.2 3.6 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EDO15810.1 - 6.9e-06 26.1 3.0 0.0065 16.6 0.0 4.0 3 1 0 3 3 3 2 RNA recognition motif Spo7_2_N PF15407.6 EDO15810.1 - 0.01 15.4 0.0 0.059 13.0 0.0 2.3 2 0 0 2 2 2 0 Sporulation protein family 7 Nup35_RRM_2 PF14605.6 EDO15810.1 - 0.039 14.0 0.0 0.14 12.2 0.0 1.9 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif Ribosomal_S19 PF00203.21 EDO15811.1 - 2.2e-34 117.2 0.5 2.9e-34 116.8 0.1 1.4 2 0 0 2 2 2 1 Ribosomal protein S19 Ribosomal_60s PF00428.19 EDO15812.1 - 1.7e-23 83.0 15.1 2.2e-23 82.7 15.1 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein PRR18 PF15671.5 EDO15812.1 - 0.32 10.9 4.0 0.42 10.5 4.0 1.2 1 0 0 1 1 1 0 Proline-rich protein family 18 Ydc2-catalyt PF09159.10 EDO15813.1 - 1.8e-51 175.5 0.0 2.4e-51 175.2 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial resolvase Ydc2 / RNA splicing MRS1 OST3_OST6 PF04756.13 EDO15814.1 - 6.2e-17 61.9 0.0 1.2e-16 61.0 0.0 1.4 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family CDC27 PF09507.10 EDO15814.1 - 0.03 13.7 29.7 0.039 13.4 29.7 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Borrelia_P83 PF05262.11 EDO15814.1 - 0.048 12.2 15.4 0.056 11.9 15.4 1.2 1 0 0 1 1 1 0 Borrelia P83/100 protein TFIIA PF03153.13 EDO15814.1 - 0.42 10.5 29.2 0.74 9.7 29.2 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CCDC53 PF10152.9 EDO15814.1 - 0.93 9.9 22.6 1.8 9.0 5.2 2.2 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex GREB1 PF15782.5 EDO15814.1 - 5.9 3.9 17.9 7 3.6 17.9 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer SOBP PF15279.6 EDO15814.1 - 7.2 7.1 24.8 9.6 6.7 24.8 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein Fungal_trans PF04082.18 EDO15815.1 - 3.1e-23 82.2 5.4 3.1e-23 82.2 5.4 2.6 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDO15815.1 - 0.00061 19.9 10.5 0.00081 19.5 9.4 1.7 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Npa1 PF11707.8 EDO15816.1 - 9.8e-94 314.5 0.9 3.9e-93 312.5 0.9 2.2 1 0 0 1 1 1 1 Ribosome 60S biogenesis N-terminal NopRA1 PF16201.5 EDO15816.1 - 2.3e-50 171.0 0.1 2.3e-50 171.0 0.1 3.0 3 0 0 3 3 3 1 Nucleolar pre-ribosomal-associated protein 1 Mt_ATP-synt_D PF05873.12 EDO15817.1 - 7.2e-19 68.2 2.3 8.8e-19 67.9 2.3 1.1 1 0 0 1 1 1 1 ATP synthase D chain, mitochondrial (ATP5H) GIDA_assoc PF13932.6 EDO15817.1 - 0.015 15.5 0.8 0.02 15.1 0.8 1.1 1 0 0 1 1 1 0 GidA associated domain AAA_12 PF13087.6 EDO15818.1 - 1.6e-57 194.4 0.0 3.2e-57 193.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 EDO15818.1 - 5.3e-54 183.8 0.0 1.4e-53 182.4 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EDO15818.1 - 1.3e-12 48.2 0.0 1.4e-11 45.0 0.0 2.5 2 1 0 2 2 2 1 AAA domain AAA_30 PF13604.6 EDO15818.1 - 6.8e-12 45.5 0.0 6.1e-10 39.1 0.0 2.6 1 1 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 EDO15818.1 - 8.2e-07 29.0 0.1 0.077 12.7 0.0 3.3 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase UvrD-helicase PF00580.21 EDO15818.1 - 1.6e-06 27.9 0.1 7.4e-06 25.7 0.0 2.2 2 1 0 2 2 2 1 UvrD/REP helicase N-terminal domain ResIII PF04851.15 EDO15818.1 - 3.3e-05 24.0 0.0 0.00011 22.2 0.0 2.0 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 EDO15818.1 - 3.8e-05 24.0 0.1 0.00089 19.5 0.0 3.1 3 1 0 3 3 2 1 AAA domain PhoH PF02562.16 EDO15818.1 - 4.9e-05 22.9 0.1 0.00041 19.9 0.0 2.4 3 0 0 3 3 3 1 PhoH-like protein Helicase_RecD PF05127.14 EDO15818.1 - 0.00014 21.8 0.0 0.0021 17.9 0.0 2.5 2 0 0 2 2 2 1 Helicase AAA_24 PF13479.6 EDO15818.1 - 0.00039 20.2 0.0 0.0009 19.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain DEAD PF00270.29 EDO15818.1 - 0.0014 18.5 0.1 0.0056 16.5 0.0 2.0 1 1 0 2 2 2 1 DEAD/DEAH box helicase PIF1 PF05970.14 EDO15818.1 - 0.0031 16.8 0.0 0.23 10.6 0.0 2.3 2 0 0 2 2 2 1 PIF1-like helicase AAA_16 PF13191.6 EDO15818.1 - 0.0053 17.1 0.0 0.019 15.3 0.0 1.9 2 0 0 2 2 2 1 AAA ATPase domain T2SSE PF00437.20 EDO15818.1 - 0.01 14.9 0.0 0.018 14.1 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein DUF2075 PF09848.9 EDO15818.1 - 0.013 14.8 0.1 0.039 13.2 0.0 1.8 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) IstB_IS21 PF01695.17 EDO15818.1 - 0.017 14.9 0.0 0.043 13.5 0.0 1.7 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_25 PF13481.6 EDO15818.1 - 0.02 14.4 0.0 0.045 13.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 EDO15818.1 - 0.023 15.1 0.8 0.2 12.1 0.2 2.8 2 1 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) TrwB_AAD_bind PF10412.9 EDO15818.1 - 0.045 12.7 0.0 0.087 11.7 0.0 1.4 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain Rad17 PF03215.15 EDO15818.1 - 0.047 13.6 0.2 11 5.9 0.0 2.8 1 1 2 3 3 3 0 Rad17 P-loop domain DUF853 PF05872.12 EDO15818.1 - 0.05 12.2 0.0 0.097 11.3 0.0 1.3 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) SepSecS PF05889.13 EDO15818.1 - 0.061 12.0 0.1 0.13 10.9 0.1 1.5 1 0 0 1 1 1 0 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS AAA_14 PF13173.6 EDO15818.1 - 0.086 12.9 0.2 5.9 6.9 0.0 3.4 3 0 0 3 3 3 0 AAA domain Zot PF05707.12 EDO15818.1 - 0.089 12.4 0.0 0.2 11.3 0.0 1.6 1 0 0 1 1 1 0 Zonular occludens toxin (Zot) gerPA PF10676.9 EDO15818.1 - 0.11 12.7 0.4 0.27 11.5 0.4 1.6 1 0 0 1 1 1 0 Spore germination protein gerPA/gerPF CbiA PF01656.23 EDO15818.1 - 0.13 12.3 0.2 0.47 10.5 0.1 2.1 2 1 0 2 2 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain MeaB PF03308.16 EDO15818.1 - 0.14 11.1 0.3 0.47 9.4 0.0 1.9 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB WD40 PF00400.32 EDO15819.1 - 3.5e-13 49.8 0.9 0.0027 18.5 0.0 5.3 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDO15819.1 - 0.00051 20.3 0.0 6.1 7.2 0.0 4.0 4 1 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain DUF1748 PF08520.10 EDO15820.1 - 3.9e-21 74.7 0.2 4.5e-21 74.5 0.2 1.0 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1748) Apc15p PF05841.11 EDO15821.1 - 1.8e-32 112.8 0.1 1.8e-32 112.8 0.1 2.4 2 1 0 2 2 2 1 Apc15p protein STT3_PglB_C PF18527.1 EDO15821.1 - 0.13 12.4 0.4 3.7 7.7 0.1 3.0 3 0 0 3 3 3 0 STT3/PglB C-terminal beta-barrel domain Nop14 PF04147.12 EDO15821.1 - 0.48 8.6 12.1 0.65 8.1 12.1 1.2 1 0 0 1 1 1 0 Nop14-like family DSPc PF00782.20 EDO15822.1 - 2.2e-24 85.8 1.6 2.7e-23 82.3 0.6 2.4 2 1 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Yippee-Mis18 PF03226.14 EDO15822.1 - 0.064 13.5 0.8 0.2 11.9 0.5 1.9 1 1 0 1 1 1 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly Y_phosphatase PF00102.27 EDO15822.1 - 0.08 12.5 0.0 0.12 11.9 0.0 1.4 1 0 0 1 1 1 0 Protein-tyrosine phosphatase PPTA PF01239.22 EDO15823.1 - 2.1e-37 125.8 17.6 2.5e-07 30.2 0.2 6.1 7 0 0 7 7 7 5 Protein prenyltransferase alpha subunit repeat WD40 PF00400.32 EDO15824.1 - 3.2e-21 75.2 6.6 5.4e-06 27.0 0.2 6.1 5 1 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDO15824.1 - 2.5e-08 34.1 3.7 0.7 10.2 0.0 5.2 2 1 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain CRT10 PF08728.10 EDO15824.1 - 0.00033 19.0 0.2 0.00033 19.0 0.2 1.8 1 1 1 2 2 2 1 CRT10 Nup160 PF11715.8 EDO15824.1 - 0.00071 18.4 0.1 0.041 12.5 0.0 2.8 2 1 1 3 3 3 1 Nucleoporin Nup120/160 FliO PF04347.13 EDO15824.1 - 0.022 15.1 0.0 7.5 6.9 0.0 2.6 2 0 0 2 2 2 0 Flagellar biosynthesis protein, FliO MraZ PF02381.18 EDO15824.1 - 0.025 14.6 0.1 22 5.1 0.0 3.6 4 0 0 4 4 4 0 MraZ protein, putative antitoxin-like PALB2_WD40 PF16756.5 EDO15824.1 - 0.043 12.7 0.2 0.23 10.3 0.0 2.3 2 1 1 3 3 3 0 Partner and localizer of BRCA2 WD40 domain SUKH_6 PF14568.6 EDO15824.1 - 0.32 11.4 4.4 0.26 11.7 0.8 2.6 3 1 1 4 4 4 0 SMI1-KNR4 cell-wall AlaDh_PNT_N PF05222.15 EDO15825.1 - 5.1e-29 101.3 0.0 7.5e-29 100.8 0.0 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain AlaDh_PNT_C PF01262.21 EDO15825.1 - 0.00091 18.6 0.0 0.0071 15.7 0.0 2.0 1 1 1 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain TPR_2 PF07719.17 EDO15826.1 - 1.2e-31 106.3 4.3 0.00096 19.1 0.0 9.7 10 0 0 10 10 9 6 Tetratricopeptide repeat TPR_1 PF00515.28 EDO15826.1 - 3.3e-31 105.8 10.2 0.00017 21.2 0.0 9.9 10 0 0 10 10 10 5 Tetratricopeptide repeat ANAPC3 PF12895.7 EDO15826.1 - 7.1e-28 96.7 8.5 3.4e-25 88.1 0.1 4.1 4 1 0 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 EDO15826.1 - 2.2e-23 80.5 11.4 0.0008 19.4 0.0 9.0 9 0 0 9 9 9 5 Tetratricopeptide repeat TPR_12 PF13424.6 EDO15826.1 - 1.2e-17 63.9 3.6 3.1e-05 24.2 0.0 7.7 7 1 0 7 7 7 2 Tetratricopeptide repeat TPR_14 PF13428.6 EDO15826.1 - 4.6e-14 51.9 0.0 0.045 14.6 0.0 8.5 5 2 4 9 9 9 2 Tetratricopeptide repeat TPR_19 PF14559.6 EDO15826.1 - 1.5e-13 51.0 2.0 0.007 16.9 0.2 6.9 3 2 5 8 8 8 3 Tetratricopeptide repeat TPR_11 PF13414.6 EDO15826.1 - 8.7e-13 47.7 0.1 7.9e-05 22.3 0.0 6.3 6 1 1 7 7 7 2 TPR repeat TPR_17 PF13431.6 EDO15826.1 - 9.7e-13 47.5 3.1 0.084 13.3 0.0 8.2 7 1 1 8 8 8 2 Tetratricopeptide repeat TPR_7 PF13176.6 EDO15826.1 - 4.8e-12 45.0 1.1 0.001 18.9 0.0 6.3 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_16 PF13432.6 EDO15826.1 - 2.8e-09 37.5 0.0 0.16 12.7 0.0 5.9 7 0 0 7 7 6 2 Tetratricopeptide repeat TPR_10 PF13374.6 EDO15826.1 - 8.9e-06 25.4 0.0 0.4 10.6 0.0 4.8 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_9 PF13371.6 EDO15826.1 - 0.00013 22.0 0.0 0.46 10.7 0.0 3.4 2 1 2 4 4 4 2 Tetratricopeptide repeat TPR_MalT PF17874.1 EDO15826.1 - 0.00013 21.4 0.0 0.02 14.3 0.0 2.6 2 1 1 3 3 3 2 MalT-like TPR region TPR_6 PF13174.6 EDO15826.1 - 0.0024 18.4 11.8 18 6.2 0.1 7.4 9 0 0 9 9 8 0 Tetratricopeptide repeat RPN7 PF10602.9 EDO15826.1 - 0.014 15.1 1.8 0.2 11.3 0.5 3.1 3 1 0 3 3 3 0 26S proteasome subunit RPN7 SRP_TPR_like PF17004.5 EDO15826.1 - 0.04 13.9 5.2 2.9 8.0 0.1 3.9 3 1 1 4 4 3 0 Putative TPR-like repeat TPR_21 PF09976.9 EDO15826.1 - 0.047 13.4 1.4 3.5 7.3 0.0 3.1 3 1 0 3 3 3 0 Tetratricopeptide repeat-like domain Fis1_TPR_C PF14853.6 EDO15826.1 - 0.25 11.4 6.9 54 4.0 0.0 5.0 5 0 0 5 5 4 0 Fis1 C-terminal tetratricopeptide repeat DUF2989 PF11207.8 EDO15826.1 - 0.36 10.5 6.8 0.29 10.9 0.5 3.1 2 1 0 3 3 3 0 Protein of unknown function (DUF2989) ADK PF00406.22 EDO15828.1 - 1.1e-47 161.9 0.0 1.5e-47 161.5 0.0 1.2 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 EDO15828.1 - 4.9e-36 124.2 0.0 7.3e-36 123.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EDO15828.1 - 1.8e-09 38.2 0.0 2.8e-09 37.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EDO15828.1 - 1.3e-06 28.6 0.0 2.8e-06 27.5 0.0 1.6 1 1 0 1 1 1 1 AAA domain Thymidylate_kin PF02223.17 EDO15828.1 - 0.00017 21.4 0.2 0.096 12.3 0.0 2.2 1 1 1 2 2 2 2 Thymidylate kinase SRP54 PF00448.22 EDO15828.1 - 0.016 14.8 0.0 0.03 14.0 0.0 1.4 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain Zeta_toxin PF06414.12 EDO15828.1 - 0.033 13.5 0.0 0.056 12.7 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin adh_short PF00106.25 EDO15829.1 - 1.4e-47 161.7 1.6 1.7e-47 161.4 1.6 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EDO15829.1 - 1.4e-31 109.9 0.3 1.8e-31 109.5 0.3 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EDO15829.1 - 2.5e-12 47.1 0.4 3.3e-12 46.7 0.4 1.1 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 EDO15829.1 - 0.00057 19.1 0.6 0.0014 17.9 0.5 1.6 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein Epimerase PF01370.21 EDO15829.1 - 0.0019 17.7 0.8 0.014 14.9 0.8 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Pkinase PF00069.25 EDO15830.1 - 0.12 11.7 0.0 0.17 11.3 0.0 1.2 1 0 0 1 1 1 0 Protein kinase domain Pan3_PK PF18101.1 EDO15831.1 - 1.4e-56 190.3 0.3 1.8e-56 190.0 0.3 1.1 1 0 0 1 1 1 1 Pan3 Pseudokinase domain HIGH_NTase1 PF05636.11 EDO15831.1 - 0.15 11.2 0.0 0.19 10.9 0.0 1.1 1 0 0 1 1 1 0 HIGH Nucleotidyl Transferase Sugar_tr PF00083.24 EDO15832.1 - 6.4e-162 539.5 34.9 7.4e-162 539.3 34.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDO15832.1 - 1.2e-27 96.8 37.5 9.3e-27 93.9 28.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF3792 PF12670.7 EDO15832.1 - 0.011 15.9 0.5 0.011 15.9 0.5 5.3 5 2 0 5 5 5 0 Protein of unknown function (DUF3792) LMF1 PF06762.14 EDO15832.1 - 0.11 11.6 1.5 0.19 10.8 1.5 1.3 1 0 0 1 1 1 0 Lipase maturation factor MFS_3 PF05977.13 EDO15832.1 - 0.17 10.2 6.1 0.048 12.0 2.8 1.7 2 0 0 2 2 2 0 Transmembrane secretion effector Epimerase PF01370.21 EDO15833.1 - 2e-16 60.2 0.1 2.9e-16 59.7 0.1 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EDO15833.1 - 9.4e-13 47.8 0.1 1.3e-12 47.4 0.1 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 EDO15833.1 - 9e-10 38.1 0.1 5e-09 35.7 0.1 1.9 1 1 0 1 1 1 1 Male sterility protein NAD_binding_10 PF13460.6 EDO15833.1 - 3.2e-08 33.7 0.0 4.7e-08 33.1 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 EDO15833.1 - 1.7e-07 31.0 0.1 2.9e-07 30.2 0.1 1.3 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase KR PF08659.10 EDO15833.1 - 1.4e-06 28.4 0.0 2.3e-06 27.6 0.0 1.3 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 EDO15833.1 - 3.4e-06 26.4 0.2 5.3e-06 25.8 0.2 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein adh_short PF00106.25 EDO15833.1 - 1.3e-05 24.7 0.3 3.8e-05 23.2 0.3 1.9 1 1 0 1 1 1 1 short chain dehydrogenase NmrA PF05368.13 EDO15833.1 - 0.0025 17.4 0.1 0.018 14.6 0.1 2.1 2 0 0 2 2 2 1 NmrA-like family F420_oxidored PF03807.17 EDO15833.1 - 0.0041 17.7 1.0 0.014 16.0 0.0 2.3 3 0 0 3 3 3 1 NADP oxidoreductase coenzyme F420-dependent adh_short_C2 PF13561.6 EDO15833.1 - 0.0078 15.8 0.1 0.017 14.7 0.1 1.5 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Shikimate_DH PF01488.20 EDO15833.1 - 0.027 14.5 0.0 0.057 13.5 0.0 1.6 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase RmlD_sub_bind PF04321.17 EDO15833.1 - 0.029 13.5 0.0 0.049 12.7 0.0 1.4 1 0 0 1 1 1 0 RmlD substrate binding domain Mannosyl_trans3 PF11051.8 EDO15834.1 - 9.9e-73 244.9 3.9 1.6e-72 244.1 3.9 1.3 1 0 0 1 1 1 1 Mannosyltransferase putative ADH_N PF08240.12 EDO15835.1 - 3.9e-25 87.9 4.5 6.4e-25 87.2 4.5 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EDO15835.1 - 8.7e-13 48.4 0.0 1.6e-12 47.5 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 EDO15835.1 - 2.9e-06 26.8 0.1 6.1e-06 25.7 0.1 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.21 EDO15835.1 - 0.0018 17.6 0.0 0.0035 16.7 0.0 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain DUF364 PF04016.12 EDO15835.1 - 0.0063 16.1 0.0 0.013 15.1 0.0 1.4 1 0 0 1 1 1 1 Putative heavy-metal chelation Hexapep_2 PF14602.6 EDO15835.1 - 0.11 12.2 2.6 0.23 11.2 0.3 2.3 2 0 0 2 2 2 0 Hexapeptide repeat of succinyl-transferase RseC_MucC PF04246.12 EDO15835.1 - 2 8.4 6.3 0.58 10.1 3.3 1.6 1 1 0 1 1 1 0 Positive regulator of sigma(E), RseC/MucC MFS_1 PF07690.16 EDO15836.1 - 3.5e-37 128.2 33.7 3.5e-37 128.2 33.7 1.7 1 1 1 2 2 2 1 Major Facilitator Superfamily OATP PF03137.20 EDO15836.1 - 0.00027 19.4 12.6 0.00087 17.7 12.1 2.2 1 1 1 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family TRI12 PF06609.13 EDO15836.1 - 0.00053 18.5 4.5 0.00088 17.8 4.5 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) PSP PF04046.16 EDO15837.1 - 0.038 13.9 0.2 0.07 13.0 0.2 1.4 1 0 0 1 1 1 0 PSP DUF2974 PF11187.8 EDO15839.1 - 0.04 13.5 0.4 0.13 11.7 0.3 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF2974) DERM PF14704.6 EDO15839.1 - 0.1 13.1 0.2 0.19 12.2 0.1 1.4 1 1 0 1 1 1 0 Dermatopontin Phytochelatin_C PF09328.10 EDO15839.1 - 0.12 11.6 1.9 0.18 11.1 1.5 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF1984) PPV_E2_N PF00508.17 EDO15839.1 - 0.28 10.5 0.3 15 4.8 0.0 2.1 1 1 1 2 2 2 0 E2 (early) protein, N terminal APC_u9 PF16633.5 EDO15839.1 - 6.7 7.9 11.4 6.8 7.9 0.9 3.3 1 1 1 2 2 2 0 Unstructured region on APC between 1st two creatine-rich regions Flocculin PF00624.18 EDO15840.1 - 2.8e-67 222.7 304.8 2.5e-10 40.4 9.6 181.6 180 1 0 180 180 180 21 Flocculin repeat Gly_radical PF01228.21 EDO15840.1 - 6.8e-48 161.6 55.8 2.1e+02 2.5 0.0 66.5 23 15 44 97 97 97 0 Glycine radical KIAA1328 PF15369.6 EDO15840.1 - 5.3 6.8 10.3 9.7 5.9 10.3 1.3 1 0 0 1 1 1 0 Uncharacterised protein KIAA1328 Hexokinase_2 PF03727.16 EDO15841.1 - 1.2e-76 257.3 0.0 1.6e-76 256.9 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 EDO15841.1 - 8.3e-69 231.5 0.0 1.1e-68 231.1 0.0 1.1 1 0 0 1 1 1 1 Hexokinase FGGY_N PF00370.21 EDO15841.1 - 0.0025 17.4 0.0 0.0052 16.4 0.0 1.4 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain DUF2294 PF10057.9 EDO15841.1 - 0.054 13.6 0.0 0.12 12.5 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2294) CSN8_PSD8_EIF3K PF10075.9 EDO15842.1 - 2.9e-20 72.7 0.2 5.1e-20 71.9 0.2 1.4 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family SAC3_GANP PF03399.16 EDO15842.1 - 0.00053 19.5 0.3 0.00084 18.8 0.3 1.3 1 0 0 1 1 1 1 SAC3/GANP family Ppx-GppA PF02541.16 EDO15843.1 - 1.5e-76 257.6 0.0 2e-76 257.2 0.0 1.2 1 0 0 1 1 1 1 Ppx/GppA phosphatase family Ribosomal_L5e PF17144.4 EDO15844.1 - 0.06 13.3 0.2 0.16 12.0 0.2 1.7 1 0 0 1 1 1 0 Ribosomal large subunit proteins 60S L5, and 50S L18 Glyco_hydro_42 PF02449.15 EDO15844.1 - 1.8 7.8 9.5 0.33 10.2 5.4 1.8 2 0 0 2 2 2 0 Beta-galactosidase Adap_comp_sub PF00928.21 EDO15845.1 - 5.3e-12 45.7 0.4 8.3e-12 45.0 0.4 1.4 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 EDO15845.1 - 7.7e-08 32.4 2.1 1.4e-07 31.6 1.8 1.6 1 1 0 1 1 1 1 Clathrin adaptor complex small chain CDC37_N PF03234.14 EDO15845.1 - 0.071 14.0 2.2 0.87 10.5 0.0 2.6 2 0 0 2 2 2 0 Cdc37 N terminal kinase binding tRNA-synt_1c PF00749.21 EDO15846.1 - 2.1e-119 398.1 0.1 2.8e-119 397.7 0.1 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.18 EDO15846.1 - 7.4e-41 139.9 0.3 1.8e-40 138.6 0.3 1.7 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain GluRS_N PF18466.1 EDO15846.1 - 1.2e-11 44.8 1.6 4.8e-11 42.9 1.6 2.1 1 0 0 1 1 1 1 Glutamate--tRNA ligase N-terminal domain GST_C_2 PF13410.6 EDO15846.1 - 0.00089 19.2 0.0 0.0025 17.8 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EDO15846.1 - 0.0022 18.2 0.0 0.0077 16.4 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain tRNA-synt_1e PF01406.19 EDO15846.1 - 0.046 13.0 0.1 0.096 12.0 0.1 1.5 1 0 0 1 1 1 0 tRNA synthetases class I (C) catalytic domain Glutaredoxin2_C PF04399.13 EDO15846.1 - 0.054 13.3 0.0 0.14 12.0 0.0 1.7 1 0 0 1 1 1 0 Glutaredoxin 2, C terminal domain DUF155 PF02582.14 EDO15847.1 - 1.1e-53 181.9 0.6 2e-53 181.1 0.6 1.4 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 Plus-3 PF03126.18 EDO15848.1 - 2.7e-29 101.9 0.1 8e-29 100.4 0.1 1.9 1 0 0 1 1 1 1 Plus-3 domain Ank PF00023.30 EDO15849.1 - 1.9e-08 34.4 0.0 0.0067 16.8 0.0 3.4 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 EDO15849.1 - 1.4e-06 28.4 0.0 0.00028 21.1 0.0 3.1 2 1 0 2 2 2 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 EDO15849.1 - 2.6e-06 27.9 0.0 4.3e-06 27.2 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EDO15849.1 - 3.2e-06 27.1 0.0 0.00099 19.4 0.0 3.4 3 1 0 3 3 3 1 Ankyrin repeat Ank_4 PF13637.6 EDO15849.1 - 0.00041 20.9 0.2 0.0047 17.5 0.0 2.2 1 1 1 2 2 2 1 Ankyrin repeats (many copies) WRNPLPNID PF15017.6 EDO15849.1 - 0.48 11.3 4.4 1.4 9.8 4.4 1.8 1 0 0 1 1 1 0 Putative WW-binding domain and destruction box CBFB_NFYA PF02045.15 EDO15850.1 - 5e-27 94.3 8.7 5e-27 94.3 8.7 1.8 2 0 0 2 2 2 1 CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B FSA_C PF10479.9 EDO15850.1 - 0.039 12.1 14.2 0.052 11.7 14.2 1.2 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus DUF3439 PF11921.8 EDO15850.1 - 1.5 8.8 13.2 3.1 7.8 13.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) RIFIN PF02009.16 EDO15850.1 - 9 6.1 12.1 0.95 9.3 7.8 1.5 2 0 0 2 2 2 0 Rifin GIDA PF01134.22 EDO15851.1 - 5.2e-155 516.4 0.0 6.4e-155 516.1 0.0 1.1 1 0 0 1 1 1 1 Glucose inhibited division protein A GIDA_assoc PF13932.6 EDO15851.1 - 1e-67 228.4 0.1 1.6e-67 227.7 0.1 1.3 1 0 0 1 1 1 1 GidA associated domain Pyr_redox_2 PF07992.14 EDO15851.1 - 2.4e-06 27.0 3.9 3.6e-05 23.1 3.8 2.5 2 1 1 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EDO15851.1 - 3.9e-05 23.2 3.3 6.7e-05 22.4 3.3 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 EDO15851.1 - 0.00065 20.2 0.6 0.0019 18.7 0.6 1.8 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EDO15851.1 - 0.001 18.3 2.9 0.002 17.3 2.9 1.5 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_3 PF13738.6 EDO15851.1 - 0.002 17.4 0.0 0.0045 16.3 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 EDO15851.1 - 0.0022 17.3 0.2 0.0043 16.4 0.2 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain HI0933_like PF03486.14 EDO15851.1 - 0.06 12.0 2.4 0.46 9.1 1.5 2.4 2 0 0 2 2 2 0 HI0933-like protein NAD_binding_7 PF13241.6 EDO15851.1 - 0.1 13.1 0.1 0.22 12.0 0.1 1.5 1 0 0 1 1 1 0 Putative NAD(P)-binding DAO PF01266.24 EDO15851.1 - 0.27 10.8 1.6 3.5 7.1 1.9 2.1 2 0 0 2 2 2 0 FAD dependent oxidoreductase SAPS PF04499.15 EDO15852.1 - 3.8e-156 520.7 30.7 2e-155 518.3 22.3 2.5 2 1 0 2 2 2 1 SIT4 phosphatase-associated protein DUF4559 PF15112.6 EDO15852.1 - 0.11 12.2 1.6 0.56 9.8 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4559) Death PF00531.22 EDO15853.1 - 0.066 13.4 0.0 9.1 6.5 0.0 2.8 2 0 0 2 2 2 0 Death domain MCM PF00493.23 EDO15855.1 - 3.7e-104 346.7 0.0 7.5e-104 345.7 0.0 1.5 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 EDO15855.1 - 7.6e-36 122.7 0.0 1.6e-35 121.7 0.0 1.5 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 EDO15855.1 - 1e-27 96.4 2.1 3e-27 94.9 2.1 1.9 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 EDO15855.1 - 5.3e-18 65.5 1.9 7.2e-18 65.1 0.7 1.9 2 0 0 2 2 2 1 MCM N-terminal domain AAA_5 PF07728.14 EDO15855.1 - 2.8e-06 27.4 0.0 9.9e-06 25.6 0.0 2.0 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 EDO15855.1 - 6.7e-06 25.6 0.0 0.0011 18.4 0.0 2.3 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 EDO15855.1 - 0.0005 19.9 0.0 0.0019 18.0 0.0 2.0 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 EDO15855.1 - 0.028 14.1 0.0 0.96 9.1 0.0 2.5 2 0 0 2 2 2 0 Sigma-54 interaction domain Imm35 PF15567.6 EDO15855.1 - 0.093 12.9 0.0 0.23 11.6 0.0 1.6 1 0 0 1 1 1 0 Immunity protein 35 zf-RING_9 PF13901.6 EDO15855.1 - 0.44 10.5 3.4 0.4 10.6 0.2 2.4 3 0 0 3 3 3 0 Putative zinc-RING and/or ribbon LSM PF01423.22 EDO15856.1 - 2.6e-18 65.5 0.6 3.3e-18 65.1 0.6 1.2 1 0 0 1 1 1 1 LSM domain Helicase_C PF00271.31 EDO15857.1 - 1.3e-31 109.2 0.3 6e-31 107.1 0.1 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 EDO15857.1 - 5.3e-15 55.6 0.1 1.2e-14 54.5 0.1 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase DUF3334 PF11813.8 EDO15857.1 - 0.024 14.4 2.7 0.047 13.4 2.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3334) DnaI_N PF07319.11 EDO15857.1 - 1.3 9.8 8.6 4.3 8.1 0.2 3.4 3 1 0 3 3 3 0 Primosomal protein DnaI N-terminus Hydrolase_3 PF08282.12 EDO15857.1 - 5.4 6.7 11.6 0.15 11.8 4.2 2.1 3 0 0 3 3 3 0 haloacid dehalogenase-like hydrolase CPSF73-100_C PF11718.8 EDO15858.1 - 8e-58 195.5 4.5 1.7e-57 194.4 4.5 1.6 1 0 0 1 1 1 1 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term Beta-Casp PF10996.8 EDO15858.1 - 1.2e-30 106.1 0.0 2.9e-30 104.8 0.0 1.7 1 0 0 1 1 1 1 Beta-Casp domain Lactamase_B PF00753.27 EDO15858.1 - 2.4e-23 83.2 0.4 3.7e-23 82.6 0.4 1.3 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_6 PF16661.5 EDO15858.1 - 1.6e-20 73.4 0.0 3.7e-20 72.2 0.0 1.6 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain RMMBL PF07521.12 EDO15858.1 - 3.8e-18 65.2 0.1 1.2e-17 63.6 0.1 1.9 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B_2 PF12706.7 EDO15858.1 - 4.8e-08 32.8 0.2 8.3e-07 28.7 0.3 2.4 2 0 0 2 2 2 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 EDO15858.1 - 1.6e-05 24.8 0.0 7.4e-05 22.7 0.0 2.1 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Beta_lactamase3 PF17030.5 EDO15858.1 - 0.0095 15.2 0.0 0.03 13.6 0.0 1.8 2 0 0 2 2 2 1 Putative beta-lactamase-like family Fungal_trans PF04082.18 EDO15859.1 - 5.1e-12 45.4 9.6 5.1e-12 45.4 9.6 1.9 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDO15859.1 - 2.2e-06 27.7 10.1 5.7e-06 26.4 10.1 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Methyltransf_16 PF10294.9 EDO15860.1 - 1.2e-11 44.7 0.0 6.1e-11 42.4 0.0 1.9 1 1 0 1 1 1 1 Lysine methyltransferase Methyltransf_23 PF13489.6 EDO15860.1 - 0.0024 17.7 0.0 0.0032 17.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 EDO15860.1 - 0.097 12.1 0.0 0.16 11.3 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Glyco_hydro_18 PF00704.28 EDO15861.1 - 2.5e-28 99.7 1.4 4e-28 99.0 1.4 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 CBM_19 PF03427.13 EDO15861.1 - 0.00015 21.6 9.4 0.00015 21.6 9.4 4.1 3 2 0 3 3 3 1 Carbohydrate binding domain (family 19) Guanylate_kin PF00625.21 EDO15861.1 - 0.023 14.4 0.2 0.039 13.6 0.2 1.3 1 0 0 1 1 1 0 Guanylate kinase GTP_EFTU PF00009.27 EDO15862.1 - 3.9e-52 176.6 0.1 8.6e-52 175.5 0.1 1.5 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain LepA_C PF06421.12 EDO15862.1 - 2.7e-37 127.2 8.1 6.5e-37 126.0 8.1 1.7 1 0 0 1 1 1 1 GTP-binding protein LepA C-terminus EFG_C PF00679.24 EDO15862.1 - 9.6e-17 60.8 0.0 2.5e-16 59.5 0.0 1.8 1 0 0 1 1 1 1 Elongation factor G C-terminus MMR_HSR1 PF01926.23 EDO15862.1 - 1.6e-06 28.2 0.2 9.8e-06 25.6 0.0 2.4 2 0 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU_D2 PF03144.25 EDO15862.1 - 0.00013 22.3 1.2 0.00013 22.3 1.2 2.4 2 1 1 3 3 3 2 Elongation factor Tu domain 2 SRPRB PF09439.10 EDO15862.1 - 0.0006 19.3 0.3 0.0021 17.5 0.1 2.1 2 1 0 2 2 2 1 Signal recognition particle receptor beta subunit SASP PF00269.20 EDO15862.1 - 0.0014 18.6 0.0 0.019 14.9 0.0 2.4 2 0 0 2 2 2 1 Small, acid-soluble spore proteins, alpha/beta type Ras PF00071.22 EDO15862.1 - 0.0031 17.1 1.7 0.0044 16.6 0.1 2.0 2 0 0 2 2 2 1 Ras family RF3_C PF16658.5 EDO15862.1 - 0.0037 17.1 0.0 0.012 15.4 0.0 1.9 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain Roc PF08477.13 EDO15862.1 - 0.011 16.0 0.4 0.32 11.2 0.0 2.9 2 1 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase EFG_II PF14492.6 EDO15862.1 - 0.037 14.1 0.0 0.11 12.7 0.0 1.8 1 0 0 1 1 1 0 Elongation Factor G, domain II DUSP PF06337.12 EDO15862.1 - 0.33 11.6 1.9 0.48 11.1 0.2 2.2 2 0 0 2 2 2 0 DUSP domain Ras PF00071.22 EDO15863.1 - 4.4e-50 169.4 0.0 5.5e-50 169.1 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EDO15863.1 - 2e-30 105.5 0.0 5.6e-30 104.0 0.0 1.7 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EDO15863.1 - 5.6e-11 42.2 0.0 7.7e-11 41.7 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family RNA_helicase PF00910.22 EDO15863.1 - 0.0013 19.1 0.1 0.0076 16.6 0.1 2.1 1 1 0 1 1 1 1 RNA helicase MMR_HSR1 PF01926.23 EDO15863.1 - 0.0025 17.9 0.0 0.006 16.7 0.0 1.6 1 1 1 2 2 2 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EDO15863.1 - 0.0035 16.7 0.0 0.005 16.2 0.0 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EDO15863.1 - 0.015 14.8 0.3 0.068 12.7 0.3 2.0 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain Pox_A32 PF04665.12 EDO15863.1 - 0.02 14.4 0.1 0.038 13.4 0.1 1.4 1 0 0 1 1 1 0 Poxvirus A32 protein RsgA_GTPase PF03193.16 EDO15863.1 - 0.026 14.5 0.1 8.5 6.3 0.0 2.2 2 0 0 2 2 2 0 RsgA GTPase AAA_7 PF12775.7 EDO15863.1 - 0.031 13.8 0.0 0.053 13.0 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region G-alpha PF00503.20 EDO15863.1 - 0.041 13.0 2.8 1.8 7.6 0.2 2.7 2 1 1 3 3 3 0 G-protein alpha subunit SRPRB PF09439.10 EDO15863.1 - 0.065 12.7 0.0 0.11 11.9 0.0 1.4 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_24 PF13479.6 EDO15863.1 - 0.066 12.9 0.2 0.13 11.9 0.2 1.5 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 EDO15863.1 - 0.085 13.0 0.4 0.21 11.7 0.1 1.7 2 0 0 2 2 2 0 AAA domain TsaE PF02367.17 EDO15863.1 - 0.1 12.6 0.1 0.25 11.4 0.1 1.7 2 0 0 2 2 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ATPase PF06745.13 EDO15863.1 - 0.11 11.9 0.2 0.16 11.3 0.2 1.2 1 0 0 1 1 1 0 KaiC AAA_16 PF13191.6 EDO15863.1 - 0.14 12.5 0.1 0.27 11.6 0.1 1.4 1 0 0 1 1 1 0 AAA ATPase domain NACHT PF05729.12 EDO15863.1 - 0.2 11.6 0.3 0.35 10.8 0.1 1.5 2 0 0 2 2 2 0 NACHT domain ATP_sub_h PF10775.9 EDO15864.1 - 3e-20 72.0 0.2 5.1e-20 71.2 0.2 1.4 1 0 0 1 1 1 1 ATP synthase complex subunit h Hormone_3 PF00159.18 EDO15864.1 - 0.038 14.1 0.2 0.079 13.0 0.2 1.6 1 0 0 1 1 1 0 Pancreatic hormone peptide DUF1515 PF07439.11 EDO15864.1 - 0.15 12.1 0.0 0.22 11.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1515) zf-U1 PF06220.12 EDO15865.1 - 4.8e-18 64.6 6.8 8.3e-18 63.9 6.8 1.4 1 0 0 1 1 1 1 U1 zinc finger GTP_EFTU PF00009.27 EDO15866.1 - 5.4e-59 199.0 0.4 7.4e-59 198.6 0.4 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 EDO15866.1 - 3.2e-29 101.5 0.0 7.1e-29 100.4 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 EDO15866.1 - 1.4e-20 73.4 2.3 3.6e-20 72.1 2.3 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EDO15866.1 - 1.8e-05 24.8 0.1 7.1e-05 22.9 0.0 2.0 2 0 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EDO15866.1 - 0.013 15.4 0.1 0.041 13.8 0.0 1.7 1 1 1 2 2 2 0 RsgA GTPase cobW PF02492.19 EDO15866.1 - 0.039 13.5 1.2 0.053 13.1 0.0 1.8 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain PduV-EutP PF10662.9 EDO15866.1 - 0.047 13.4 0.2 9.9 5.9 0.0 2.5 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation G_glu_transpept PF01019.21 EDO15867.1 - 4.8e-141 471.0 0.0 5.8e-141 470.8 0.0 1.0 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase DUF1708 PF08101.11 EDO15868.1 - 4.8e-95 319.3 12.0 2.3e-80 270.9 6.1 2.2 1 1 1 2 2 2 2 Domain of unknown function (DUF1708) INO80_Ies4 PF08193.11 EDO15869.1 - 0.003 17.6 5.5 0.003 17.6 5.5 1.5 1 1 0 1 1 1 1 INO80 complex subunit Ies4 Cellulase PF00150.18 EDO15870.1 - 3.8e-11 42.9 0.3 3.8e-11 42.9 0.3 1.7 2 0 0 2 2 2 1 Cellulase (glycosyl hydrolase family 5) SNF2_N PF00176.23 EDO15871.1 - 1.6e-57 194.8 0.1 1.1e-56 192.1 0.0 2.3 2 0 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EDO15871.1 - 1.9e-18 66.8 1.6 8e-18 64.8 0.1 2.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain zf-RING_5 PF14634.6 EDO15871.1 - 5e-05 23.2 3.6 0.00011 22.1 3.6 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EDO15871.1 - 0.00072 19.5 1.1 0.0018 18.2 1.1 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 EDO15871.1 - 0.0017 18.1 0.8 0.0041 16.9 0.8 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EDO15871.1 - 0.0037 17.1 4.0 0.0083 16.0 4.0 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EDO15871.1 - 0.0058 16.9 4.8 0.013 15.8 4.8 1.7 1 0 0 1 1 1 1 Ring finger domain Prok-RING_4 PF14447.6 EDO15871.1 - 0.0067 16.3 2.0 0.015 15.1 2.0 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 EDO15871.1 - 0.04 13.8 1.4 0.1 12.4 1.4 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EDO15871.1 - 2 8.7 4.4 7 6.9 4.4 2.0 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING GvpG PF05120.12 EDO15871.1 - 7.2 6.7 12.6 0.086 12.9 2.8 3.0 3 0 0 3 3 3 0 Gas vesicle protein G CBM_21 PF03370.13 EDO15872.1 - 1.1e-28 99.6 3.5 1.1e-28 99.6 3.5 2.4 2 1 0 2 2 2 1 Carbohydrate/starch-binding module (family 21) CBM53 PF16760.5 EDO15872.1 - 2.5e-12 47.2 1.7 9.2e-12 45.4 1.7 2.0 1 0 0 1 1 1 1 Starch/carbohydrate-binding module (family 53) EXS PF03124.14 EDO15873.1 - 3.3e-90 302.7 25.4 5.9e-90 301.9 25.4 1.4 1 0 0 1 1 1 1 EXS family SPX PF03105.19 EDO15873.1 - 3.4e-30 106.3 19.0 7.5e-19 68.9 4.4 2.8 2 1 1 3 3 3 2 SPX domain PhoLip_ATPase_C PF16212.5 EDO15874.1 - 1.8e-51 175.3 19.3 1.8e-51 175.3 19.3 2.2 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EDO15874.1 - 1.7e-18 66.1 3.4 5.6e-18 64.4 3.4 1.9 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal E1-E2_ATPase PF00122.20 EDO15874.1 - 8.2e-16 58.0 0.1 2.5e-15 56.5 0.1 1.8 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.26 EDO15874.1 - 1.5e-10 41.8 1.4 3.6e-06 27.4 1.0 3.0 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EDO15874.1 - 2.2e-10 40.5 0.0 3.1e-09 36.8 0.0 2.6 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 EDO15874.1 - 0.0014 18.4 0.5 0.007 16.1 0.1 2.4 1 1 1 2 2 2 1 haloacid dehalogenase-like hydrolase DUF2070 PF09843.9 EDO15874.1 - 0.24 9.6 10.6 0.65 8.2 10.6 1.8 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Steroid_dh PF02544.16 EDO15875.1 - 1.4e-07 31.6 8.0 1.4e-07 31.6 8.0 1.9 1 1 1 2 2 2 1 3-oxo-5-alpha-steroid 4-dehydrogenase DUF4064 PF13273.6 EDO15875.1 - 0.36 11.1 3.5 1.8 8.9 0.2 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF4064) Ribosomal_L34e PF01199.18 EDO15876.1 - 3.8e-14 52.8 0.6 3.8e-14 52.8 0.6 2.0 2 0 0 2 2 2 1 Ribosomal protein L34e Ribonuc_L-PSP PF01042.21 EDO15877.1 - 9.7e-41 138.6 0.4 1.1e-40 138.4 0.4 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP CCD PF07860.11 EDO15877.1 - 0.16 12.0 0.0 0.2 11.7 0.0 1.1 1 0 0 1 1 1 0 WisP family C-Terminal Region PET117 PF15786.5 EDO15878.1 - 1e-29 102.6 6.3 6.8e-29 99.9 6.3 1.9 1 1 0 1 1 1 1 PET assembly of cytochrome c oxidase, mitochondrial DUF3313 PF11769.8 EDO15878.1 - 0.068 13.0 0.8 0.085 12.7 0.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3313) Sugar_tr PF00083.24 EDO15878.1 - 0.14 11.0 0.0 0.15 10.9 0.0 1.0 1 0 0 1 1 1 0 Sugar (and other) transporter Transp_cyt_pur PF02133.15 EDO15879.1 - 7e-84 282.1 40.8 8.5e-84 281.9 40.8 1.1 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin DUF4579 PF15158.6 EDO15879.1 - 0.92 9.2 3.3 0.6 9.9 0.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4579) HAD_2 PF13419.6 EDO15880.1 - 3.6e-16 59.7 0.0 4.7e-16 59.4 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EDO15880.1 - 3.6e-12 47.0 0.0 4.6e-10 40.1 0.0 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EDO15880.1 - 0.0022 18.0 0.0 0.0047 17.0 0.0 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like HAD PF12710.7 EDO15880.1 - 0.012 16.0 0.0 0.018 15.5 0.0 1.3 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase V_ATPase_I PF01496.19 EDO15881.1 - 0 1018.4 14.0 0 1018.2 14.0 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family Baculo_PEP_C PF04513.12 EDO15881.1 - 1.3 9.1 5.1 5.2 7.1 0.1 2.5 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus HSP70 PF00012.20 EDO15882.1 - 5.9e-53 180.0 2.1 5.9e-53 180.0 2.1 3.2 2 2 0 2 2 2 1 Hsp70 protein GP3_package PF16677.5 EDO15882.1 - 0.021 14.9 0.0 0.25 11.5 0.0 2.7 2 0 0 2 2 2 0 DNA-packaging protein gp3 Uds1 PF15456.6 EDO15882.1 - 6.4 6.9 9.8 2.1 8.5 6.1 2.1 2 0 0 2 2 2 0 Up-regulated During Septation RabGAP-TBC PF00566.18 EDO15883.1 - 3.3e-37 128.2 2.3 5.5e-37 127.5 2.3 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Mito_carr PF00153.27 EDO15884.1 - 9e-67 221.1 8.0 1.7e-23 82.3 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Fuseless PF15993.5 EDO15884.1 - 0.0028 16.9 0.1 0.018 14.3 0.1 1.9 2 0 0 2 2 2 1 Fuseless RRN3 PF05327.11 EDO15885.1 - 0.0031 16.1 5.9 0.0058 15.2 5.9 1.4 1 0 0 1 1 1 1 RNA polymerase I specific transcription initiation factor RRN3 DNA_pol_phi PF04931.13 EDO15885.1 - 0.0071 14.5 16.0 0.014 13.5 16.0 1.4 1 0 0 1 1 1 1 DNA polymerase phi Nop14 PF04147.12 EDO15885.1 - 0.043 12.0 14.0 0.073 11.3 14.0 1.3 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.14 EDO15885.1 - 0.11 10.8 10.8 0.18 10.1 10.8 1.3 1 0 0 1 1 1 0 CDC45-like protein FAM176 PF14851.6 EDO15885.1 - 0.48 10.1 10.3 0.079 12.6 4.9 2.5 3 0 0 3 3 3 0 FAM176 family TRAP_alpha PF03896.16 EDO15885.1 - 0.63 9.2 10.8 0.14 11.3 6.8 2.0 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit CAC1F_C PF16885.5 EDO15885.1 - 1.1 8.8 6.5 1.9 8.1 6.5 1.3 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term PDDEXK_6 PF04720.12 EDO15885.1 - 1.1 9.1 6.9 0.48 10.3 4.2 1.7 2 0 0 2 2 2 0 PDDEXK-like family of unknown function DUF4628 PF15429.6 EDO15885.1 - 1.4 8.6 8.7 2.5 7.7 8.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4628) CPSF100_C PF13299.6 EDO15885.1 - 5.5 7.1 7.9 0.45 10.7 3.3 1.5 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal CobT PF06213.12 EDO15885.1 - 6.8 6.0 16.2 12 5.1 16.2 1.4 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DUF4448 PF14610.6 EDO15886.1 - 5e-46 156.9 0.1 6.9e-46 156.4 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) Sen15 PF09631.10 EDO15887.1 - 5.6e-26 90.8 0.0 6.4e-26 90.6 0.0 1.0 1 0 0 1 1 1 1 Sen15 protein P16-Arc PF04699.14 EDO15887.1 - 0.047 14.2 0.0 0.064 13.8 0.0 1.2 1 0 0 1 1 1 0 ARP2/3 complex 16 kDa subunit (p16-Arc) Tom37_C PF11801.8 EDO15888.1 - 4.8e-52 175.8 1.2 7.2e-52 175.3 1.2 1.2 1 0 0 1 1 1 1 Tom37 C-terminal domain Tom37 PF10568.9 EDO15888.1 - 5.7e-32 110.7 0.2 5.4e-31 107.5 0.0 2.2 1 1 1 2 2 2 1 Outer mitochondrial membrane transport complex protein GST_N_4 PF17172.4 EDO15888.1 - 0.00011 22.8 0.0 0.00066 20.4 0.0 2.2 2 0 0 2 2 2 1 Glutathione S-transferase N-terminal domain DUF4959 PF16323.5 EDO15888.1 - 0.15 12.4 0.0 0.36 11.2 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4959) Suf PF05843.14 EDO15889.1 - 8.7e-58 196.6 24.2 1.6e-52 179.4 8.6 3.9 2 2 2 4 4 4 2 Suppressor of forked protein (Suf) TPR_14 PF13428.6 EDO15889.1 - 0.0049 17.6 0.0 0.85 10.6 0.0 4.0 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_19 PF14559.6 EDO15889.1 - 0.057 13.9 0.0 13 6.4 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_17 PF13431.6 EDO15889.1 - 0.076 13.4 1.8 4 8.0 0.1 3.9 3 0 0 3 3 3 0 Tetratricopeptide repeat Tht1 PF04163.12 EDO15890.1 - 8.5e-37 127.1 13.9 8.5e-37 127.1 13.9 2.0 1 1 1 2 2 2 2 Tht1-like nuclear fusion protein Guanylin PF02058.15 EDO15890.1 - 0.039 14.4 0.9 0.23 11.9 0.1 2.5 3 0 0 3 3 3 0 Guanylin precursor Baculo_PEP_C PF04513.12 EDO15890.1 - 0.11 12.5 6.9 2.5 8.2 0.9 2.5 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF948 PF06103.11 EDO15890.1 - 0.18 12.1 1.6 10 6.4 0.1 2.8 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Kinesin PF00225.23 EDO15891.1 - 5.8e-59 199.7 8.7 5.8e-59 199.7 8.7 2.1 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 EDO15891.1 - 3.3e-19 69.3 2.0 3.3e-19 69.3 2.0 2.5 2 0 0 2 2 2 1 Microtubule binding DUF4407 PF14362.6 EDO15891.1 - 0.15 11.4 6.8 0.25 10.6 6.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF2203 PF09969.9 EDO15891.1 - 2 9.2 6.3 26 5.6 0.4 2.6 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) FlxA PF14282.6 EDO15891.1 - 2.2 8.3 11.7 5.7 7.0 6.2 3.0 3 1 0 3 3 3 0 FlxA-like protein V-ATPase_C PF03223.15 EDO15892.1 - 1.8e-117 392.9 9.2 2e-117 392.7 9.2 1.0 1 0 0 1 1 1 1 V-ATPase subunit C Imm39 PF15568.6 EDO15892.1 - 0.088 12.9 0.0 0.19 11.9 0.0 1.5 1 0 0 1 1 1 0 Immunity protein 39 PCI PF01399.27 EDO15893.1 - 4.6e-22 78.5 0.1 4.6e-22 78.5 0.1 3.2 3 0 0 3 3 3 1 PCI domain RPN5_C PF18098.1 EDO15893.1 - 9.1e-16 57.7 4.6 2.6e-15 56.2 4.6 1.9 1 0 0 1 1 1 1 26S proteasome regulatory subunit RPN5 C-terminal domain eIF3m_C_helix PF18005.1 EDO15893.1 - 0.52 10.0 1.7 4.8 7.0 0.1 2.6 2 0 0 2 2 2 0 eIF3 subunit M, C-terminal helix DUF5099 PF17025.5 EDO15893.1 - 1.1 9.7 0.0 1.1 9.7 0.0 3.6 2 1 2 4 4 4 0 Domain of unknown function (DUF5099) Spectrin PF00435.21 EDO15894.1 - 0.038 14.5 5.9 0.072 13.6 5.9 1.4 1 0 0 1 1 1 0 Spectrin repeat Carbpep_Y_N PF05388.11 EDO15894.1 - 0.11 13.0 7.9 0.14 12.7 7.3 1.4 1 1 0 1 1 1 0 Carboxypeptidase Y pro-peptide DUF2013 PF09431.10 EDO15895.1 - 2.7e-38 131.2 15.7 2.7e-38 131.2 15.7 2.0 2 1 0 2 2 2 1 Protein of unknown function (DUF2013) Glyco_hydro_16 PF00722.21 EDO15896.1 - 2.8e-45 153.9 2.8 2.8e-45 153.9 2.8 1.9 2 0 0 2 2 2 1 Glycosyl hydrolases family 16 WAP PF00095.21 EDO15896.1 - 0.011 16.2 3.9 0.02 15.3 3.9 1.4 1 0 0 1 1 1 0 WAP-type (Whey Acidic Protein) 'four-disulfide core' Nodulin_late PF07127.11 EDO15896.1 - 0.033 14.5 0.6 0.072 13.4 0.6 1.5 1 0 0 1 1 1 0 Late nodulin protein Chitin_bind_1 PF00187.19 EDO15896.1 - 3 8.4 11.2 5.4 7.6 11.2 1.4 1 0 0 1 1 1 0 Chitin recognition protein ApbA_C PF08546.11 EDO15897.1 - 2.2e-24 86.0 0.1 4.1e-24 85.2 0.1 1.5 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal ApbA PF02558.16 EDO15897.1 - 1.6e-21 76.5 0.0 2.4e-21 76.0 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA NAD_binding_7 PF13241.6 EDO15897.1 - 0.033 14.6 0.0 0.074 13.5 0.0 1.6 1 0 0 1 1 1 0 Putative NAD(P)-binding DAO PF01266.24 EDO15897.1 - 0.067 12.8 0.3 0.093 12.3 0.3 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase Shikimate_DH PF01488.20 EDO15897.1 - 0.13 12.3 0.0 0.49 10.5 0.0 2.0 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase Ferric_reduct PF01794.19 EDO15898.1 - 2.8e-25 88.9 15.0 7.5e-25 87.5 9.3 2.6 2 0 0 2 2 2 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.12 EDO15898.1 - 1.9e-15 57.3 0.1 3.5e-15 56.5 0.1 1.4 1 0 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 EDO15898.1 - 2.2e-14 53.4 0.0 4.9e-14 52.3 0.0 1.5 1 0 0 1 1 1 1 FAD-binding domain CFEM PF05730.11 EDO15898.1 - 0.0052 16.9 1.9 0.011 15.8 1.9 1.5 1 0 0 1 1 1 1 CFEM domain Ferric_reduct PF01794.19 EDO15899.1 - 6.8e-25 87.6 14.6 1.1e-24 87.0 9.1 2.6 2 0 0 2 2 2 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.12 EDO15899.1 - 2.7e-16 59.6 0.0 6.2e-16 58.5 0.0 1.6 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_6 PF08030.12 EDO15899.1 - 8.5e-13 48.7 0.0 1.8e-12 47.6 0.0 1.5 1 0 0 1 1 1 1 Ferric reductase NAD binding domain DUF4405 PF14358.6 EDO15899.1 - 0.085 13.4 0.4 0.085 13.4 0.4 3.5 3 1 0 3 3 3 0 Domain of unknown function (DUF4405) CFEM PF05730.11 EDO15899.1 - 0.11 12.7 3.2 0.2 11.8 3.2 1.4 1 0 0 1 1 1 0 CFEM domain D123 PF07065.14 EDO15900.1 - 3.6e-115 384.3 6.6 3.6e-115 384.3 6.6 1.3 2 0 0 2 2 2 1 D123 R2K_3 PF14243.6 EDO15900.1 - 0.045 13.8 0.0 0.092 12.7 0.0 1.5 1 1 0 1 1 1 0 ATP-grasp domain, R2K clade family 3 Cpn60_TCP1 PF00118.24 EDO15901.1 - 7.8e-148 493.1 12.1 8.8e-148 493.0 12.1 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family CDP-OH_P_transf PF01066.21 EDO15902.1 - 2.8e-15 56.8 0.8 2.8e-15 56.8 0.8 1.9 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase BPL_N PF09825.9 EDO15903.1 - 1.2e-120 403.0 0.0 1.5e-120 402.7 0.0 1.1 1 0 0 1 1 1 1 Biotin-protein ligase, N terminal BPL_LplA_LipB PF03099.19 EDO15903.1 - 2.8e-24 85.5 0.1 6e-24 84.4 0.1 1.6 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family BPL_C PF02237.17 EDO15903.1 - 9.9e-11 41.4 0.0 1.8e-10 40.5 0.0 1.5 1 0 0 1 1 1 1 Biotin protein ligase C terminal domain GATase PF00117.28 EDO15903.1 - 0.12 12.1 0.0 0.26 11.1 0.0 1.5 1 0 0 1 1 1 0 Glutamine amidotransferase class-I Death PF00531.22 EDO15904.1 - 1.1 9.4 5.5 3.5 7.8 0.3 2.9 2 2 1 3 3 3 0 Death domain Syntaxin_2 PF14523.6 EDO15904.1 - 4.1 7.8 12.8 6.7e+02 0.7 12.8 2.8 1 1 0 1 1 1 0 Syntaxin-like protein RNA_pol_Rpb1_1 PF04997.12 EDO15906.1 - 3.8e-93 312.2 0.1 4.5e-93 312.0 0.1 1.0 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 Bac_luciferase PF00296.20 EDO15906.1 - 0.064 12.7 0.0 0.091 12.2 0.0 1.1 1 0 0 1 1 1 0 Luciferase-like monooxygenase Scm3 PF10384.9 EDO15907.1 - 1.3e-21 76.0 0.3 3.9e-21 74.5 0.3 1.9 1 0 0 1 1 1 1 Centromere protein Scm3 CHCH PF06747.13 EDO15908.1 - 1.5e-05 25.0 3.3 2.8e-05 24.1 3.3 1.5 1 0 0 1 1 1 1 CHCH domain MOFRL PF05161.13 EDO15908.1 - 0.043 14.0 0.0 0.048 13.9 0.0 1.1 1 0 0 1 1 1 0 MOFRL family CbiK PF06180.11 EDO15908.1 - 0.043 13.1 0.1 0.052 12.9 0.1 1.1 1 0 0 1 1 1 0 Cobalt chelatase (CbiK) Sec31 PF11549.8 EDO15909.1 - 1.3e-25 89.1 6.3 4.8e-25 87.2 6.3 2.1 1 0 0 1 1 1 1 Protein transport protein SEC31 SRA1 PF07304.11 EDO15909.1 - 1.8e-08 34.3 0.6 4.3e-07 29.8 0.0 2.9 2 0 0 2 2 2 1 Steroid receptor RNA activator (SRA1) ANAPC4_WD40 PF12894.7 EDO15909.1 - 1e-07 32.2 2.8 0.68 10.3 0.0 4.5 2 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EDO15909.1 - 7e-06 26.7 14.5 0.00088 20.0 0.3 5.7 7 0 0 7 7 7 2 WD domain, G-beta repeat Sec16_C PF12931.7 EDO15909.1 - 3.8e-05 23.5 0.6 0.00018 21.3 0.1 2.3 2 1 0 2 2 2 1 Sec23-binding domain of Sec16 Prp18 PF02840.15 EDO15909.1 - 9e-05 22.5 0.1 0.00036 20.6 0.1 2.0 1 0 0 1 1 1 1 Prp18 domain Sugar_tr PF00083.24 EDO15910.1 - 3.7e-125 418.3 29.3 4.4e-125 418.1 29.3 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDO15910.1 - 4.9e-23 81.6 40.6 1e-19 70.7 22.9 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Pex14_N PF04695.13 EDO15910.1 - 0.025 15.3 5.7 1 10.0 0.1 3.3 3 0 0 3 3 3 0 Peroxisomal membrane anchor protein (Pex14p) conserved region GOLD_2 PF13897.6 EDO15910.1 - 1.7 9.2 8.3 2.2 8.8 0.1 3.8 3 1 1 4 4 4 0 Golgi-dynamics membrane-trafficking Arf PF00025.21 EDO15911.1 - 3.4e-78 261.1 0.0 3.9e-78 260.9 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EDO15911.1 - 1.4e-14 54.3 0.1 1.9e-14 53.9 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EDO15911.1 - 3e-14 52.9 0.0 3.2e-14 52.8 0.0 1.1 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 EDO15911.1 - 7.3e-14 51.6 0.0 8.9e-14 51.3 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 EDO15911.1 - 5.2e-12 45.6 1.0 3.8e-08 32.9 0.1 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.12 EDO15911.1 - 1.4e-09 37.7 0.0 1.7e-09 37.4 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EDO15911.1 - 1.9e-05 24.7 0.0 3e-05 24.1 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRP54 PF00448.22 EDO15911.1 - 0.0081 15.8 0.2 0.015 14.9 0.2 1.4 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain ABC_tran PF00005.27 EDO15911.1 - 0.038 14.5 0.1 0.07 13.7 0.1 1.5 1 1 0 1 1 1 0 ABC transporter AAA_33 PF13671.6 EDO15911.1 - 0.041 14.0 0.6 0.1 12.8 0.6 1.9 1 1 0 1 1 1 0 AAA domain 6PF2K PF01591.18 EDO15911.1 - 0.047 13.0 0.2 0.072 12.4 0.2 1.6 1 1 0 1 1 1 0 6-phosphofructo-2-kinase cobW PF02492.19 EDO15911.1 - 0.053 13.1 0.1 7.5 6.1 0.2 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain GTP_EFTU PF00009.27 EDO15911.1 - 0.055 13.0 0.0 0.17 11.4 0.0 1.6 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EDO15911.1 - 0.068 13.1 0.1 9.7 6.1 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase AAA_18 PF13238.6 EDO15911.1 - 0.089 13.3 0.1 0.14 12.7 0.1 1.4 1 1 0 1 1 1 0 AAA domain NACHT PF05729.12 EDO15911.1 - 0.15 12.0 0.4 14 5.6 0.0 2.1 2 0 0 2 2 2 0 NACHT domain Thymidylate_kin PF02223.17 EDO15911.1 - 0.24 11.1 0.5 0.97 9.1 0.3 1.8 2 0 0 2 2 2 0 Thymidylate kinase Ribosomal_L29 PF00831.23 EDO15912.1 - 1.1e-16 60.5 2.6 1.1e-16 60.5 2.6 2.1 2 1 0 2 2 2 1 Ribosomal L29 protein Mhr1 PF12829.7 EDO15912.1 - 0.017 15.2 0.9 0.029 14.4 0.3 1.7 1 1 1 2 2 2 0 Transcriptional regulation of mitochondrial recombination DUF4972 PF16342.5 EDO15912.1 - 0.046 13.4 3.6 1.1 9.0 0.4 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4972) PilJ PF13675.6 EDO15912.1 - 0.11 12.6 2.5 0.13 12.3 0.8 1.8 1 1 1 2 2 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term Urate_ox_N PF06181.11 EDO15912.1 - 0.23 10.8 0.1 0.31 10.3 0.1 1.1 1 0 0 1 1 1 0 Urate oxidase N-terminal R3H PF01424.22 EDO15913.1 - 4.9e-09 36.1 0.0 1.1e-08 34.9 0.0 1.6 1 0 0 1 1 1 1 R3H domain SUZ PF12752.7 EDO15913.1 - 0.027 15.2 0.5 0.027 15.2 0.5 2.8 4 1 0 4 4 4 0 SUZ domain Aminotran_1_2 PF00155.21 EDO15914.1 - 7.3e-42 143.8 0.0 9.1e-42 143.5 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 EDO15914.1 - 1e-07 31.3 0.0 4.2e-07 29.2 0.0 1.7 2 0 0 2 2 2 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 EDO15914.1 - 1.7e-06 26.8 0.0 2.4e-06 26.3 0.0 1.1 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Beta_elim_lyase PF01212.21 EDO15914.1 - 2.8e-06 26.8 0.0 4.7e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase Alliinase_C PF04864.13 EDO15914.1 - 0.041 12.7 0.0 0.093 11.6 0.0 1.6 1 1 0 1 1 1 0 Allinase Phos_pyr_kin PF08543.12 EDO15915.1 - 1e-10 41.4 0.0 1.4e-10 41.0 0.0 1.1 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase PfkB PF00294.24 EDO15915.1 - 1.3e-05 24.7 0.1 5.1e-05 22.7 0.1 1.9 1 1 0 1 1 1 1 pfkB family carbohydrate kinase SKN1 PF03935.15 EDO15916.1 - 3.7e-254 843.7 5.8 4.7e-254 843.4 5.8 1.1 1 0 0 1 1 1 1 Beta-glucan synthesis-associated protein (SKN1) DUF1438 PF07270.11 EDO15916.1 - 0.044 13.9 1.9 4 7.5 0.1 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF1438) SIS PF01380.22 EDO15917.1 - 1.1e-13 51.1 0.1 1.6e-13 50.6 0.1 1.3 1 0 0 1 1 1 1 SIS domain SIS_2 PF13580.6 EDO15917.1 - 5.1e-07 29.8 0.0 0.0018 18.3 0.0 2.2 1 1 1 2 2 2 2 SIS domain Eno-Rase_NADH_b PF12242.8 EDO15917.1 - 0.053 13.3 0.1 0.12 12.1 0.1 1.6 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Vps62 PF06101.11 EDO15919.1 - 1.2e-08 33.8 9.6 1.8e-07 29.9 9.6 2.5 1 1 0 1 1 1 1 Vacuolar protein sorting-associated protein 62 RAG2 PF03089.14 EDO15919.1 - 0.098 11.6 0.0 0.16 10.9 0.0 1.2 1 0 0 1 1 1 0 Recombination activating protein 2 NCA2 PF08637.10 EDO15920.1 - 2.4e-96 322.3 7.0 4.5e-96 321.4 7.0 1.5 1 0 0 1 1 1 1 ATP synthase regulation protein NCA2 MtrG PF04210.13 EDO15920.1 - 0.071 13.0 0.2 0.55 10.1 0.1 2.6 2 0 0 2 2 2 0 Tetrahydromethanopterin S-methyltransferase, subunit G TRCF PF03461.15 EDO15920.1 - 0.55 10.6 4.8 1.7 9.0 0.0 3.4 4 0 0 4 4 4 0 TRCF domain SH3_1 PF00018.28 EDO15921.1 - 1.7e-13 49.9 0.0 2.7e-13 49.3 0.0 1.3 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EDO15921.1 - 1.9e-12 46.8 0.2 4.6e-12 45.6 0.0 1.7 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.17 EDO15921.1 - 7.9e-11 41.5 0.0 1.3e-10 40.8 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain TFIIA PF03153.13 EDO15921.1 - 0.094 12.7 19.0 0.1 12.5 19.0 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PAT1 PF09770.9 EDO15921.1 - 0.26 9.5 13.9 0.28 9.4 13.9 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Suf PF05843.14 EDO15921.1 - 3.6 7.5 13.9 4.8 7.1 13.9 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DGF-1_C PF11040.8 EDO15921.1 - 5.1 7.2 6.1 8 6.5 5.2 1.9 1 1 0 1 1 1 0 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus Tmemb_170 PF10190.9 EDO15922.1 - 1.9e-15 57.1 9.1 2.4e-15 56.8 9.1 1.1 1 0 0 1 1 1 1 Putative transmembrane protein 170 Proteasome PF00227.26 EDO15923.1 - 4e-59 199.3 1.0 5e-59 199.0 1.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EDO15923.1 - 4.6e-12 45.4 0.9 8.4e-12 44.5 0.2 1.9 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature Nitrate_red_gam PF02665.14 EDO15923.1 - 0.2 11.2 0.0 0.29 10.7 0.0 1.2 1 0 0 1 1 1 0 Nitrate reductase gamma subunit WW PF00397.26 EDO15924.1 - 1.4e-10 41.1 4.3 3.5e-08 33.4 2.1 2.5 2 0 0 2 2 2 2 WW domain FF PF01846.19 EDO15924.1 - 1.7e-09 37.7 2.8 1.7e-09 37.7 2.8 4.1 4 0 0 4 4 4 2 FF domain RNA_pol_Rbc25 PF08292.12 EDO15925.1 - 1.5 9.0 3.9 7.3 6.8 0.1 2.5 2 0 0 2 2 2 0 RNA polymerase III subunit Rpc25 UQ_con PF00179.26 EDO15926.1 - 8.6e-39 132.4 0.1 9.5e-39 132.3 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EDO15926.1 - 4.3e-05 23.2 0.0 5.1e-05 23.0 0.0 1.1 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 EDO15926.1 - 0.00024 21.3 0.4 0.00032 21.0 0.4 1.3 1 1 0 1 1 1 1 RWD domain UFC1 PF08694.11 EDO15926.1 - 0.0015 18.2 0.1 0.0023 17.6 0.0 1.4 2 0 0 2 2 2 1 Ubiquitin-fold modifier-conjugating enzyme 1 SYF2 PF08231.12 EDO15928.1 - 4.1e-09 37.0 26.8 4.1e-09 37.0 26.8 2.1 1 1 1 2 2 2 1 SYF2 splicing factor Secretin_N PF03958.17 EDO15928.1 - 0.013 15.9 0.1 0.019 15.4 0.1 1.4 1 0 0 1 1 1 0 Bacterial type II/III secretion system short domain YtxH PF12732.7 EDO15928.1 - 1.4 9.5 12.3 2.1 8.9 2.6 3.1 2 1 1 3 3 3 0 YtxH-like protein Utp8 PF10395.9 EDO15929.1 - 7.6e-237 788.2 33.7 9e-237 787.9 33.7 1.1 1 0 0 1 1 1 1 Utp8 family ANAPC4_WD40 PF12894.7 EDO15929.1 - 0.077 13.3 0.1 0.3 11.4 0.0 2.0 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain LIDHydrolase PF10230.9 EDO15930.1 - 2.4e-71 240.4 0.5 2.8e-71 240.2 0.5 1.0 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase Hydrolase_4 PF12146.8 EDO15930.1 - 0.011 15.0 0.0 0.025 13.9 0.0 1.8 1 1 0 1 1 1 0 Serine aminopeptidase, S33 DUF1057 PF06342.12 EDO15930.1 - 0.025 13.6 0.6 4.1 6.4 0.0 2.1 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF1057) Abhydrolase_6 PF12697.7 EDO15930.1 - 0.12 12.9 0.0 0.15 12.6 0.0 1.3 1 1 0 1 1 1 0 Alpha/beta hydrolase family DUF3089 PF11288.8 EDO15930.1 - 0.16 11.5 0.0 0.24 10.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3089) Sulfate_transp PF00916.20 EDO15931.1 - 6.2e-77 258.9 25.0 9e-77 258.4 25.0 1.2 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 EDO15931.1 - 2.2e-13 49.9 1.5 4.4e-13 48.9 1.5 1.5 1 0 0 1 1 1 1 STAS domain cNMP_binding PF00027.29 EDO15931.1 - 0.022 14.8 0.0 0.045 13.8 0.0 1.5 1 0 0 1 1 1 0 Cyclic nucleotide-binding domain Asn_synthase PF00733.21 EDO15932.1 - 3.4e-94 316.4 0.3 2.7e-54 185.2 0.0 2.1 1 1 1 2 2 2 2 Asparagine synthase GATase_7 PF13537.6 EDO15932.1 - 6.8e-33 113.2 0.0 1.2e-32 112.5 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.6 EDO15932.1 - 1.6e-26 93.1 0.0 5.7e-26 91.3 0.0 1.9 2 0 0 2 2 2 1 Glutamine amidotransferase domain DUF3700 PF12481.8 EDO15932.1 - 2.1e-06 27.4 0.0 4.6e-06 26.3 0.0 1.5 1 0 0 1 1 1 1 Aluminium induced protein NAD_synthase PF02540.17 EDO15932.1 - 0.02 14.0 0.0 0.032 13.4 0.0 1.2 1 0 0 1 1 1 0 NAD synthase F-box-like PF12937.7 EDO15933.1 - 9e-05 22.3 0.0 0.00024 20.9 0.0 1.8 1 0 0 1 1 1 1 F-box-like Sarcoglycan_1 PF04790.13 EDO15933.1 - 0.0031 16.9 2.3 0.0048 16.3 2.0 1.4 1 1 0 1 1 1 1 Sarcoglycan complex subunit protein Phage_int_SAM_2 PF12834.7 EDO15933.1 - 0.042 14.5 0.1 0.14 12.8 0.1 2.0 1 0 0 1 1 1 0 Phage integrase, N-terminal zf-C3HC4_4 PF15227.6 EDO15935.1 - 2.5e-11 43.5 11.8 2.5e-11 43.5 11.8 2.4 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.6 EDO15935.1 - 2.7e-08 33.7 5.5 2.7e-08 33.7 5.5 1.9 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 EDO15935.1 - 3.5e-08 33.2 13.1 4.6e-08 32.8 5.7 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EDO15935.1 - 1.5e-07 31.2 9.6 1.5e-07 31.2 9.6 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EDO15935.1 - 1.7e-07 31.5 8.8 1.7e-07 31.5 8.8 2.3 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 EDO15935.1 - 1.8e-06 27.7 8.9 1.8e-06 27.7 8.9 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EDO15935.1 - 8.5e-05 22.4 7.7 8.5e-05 22.4 7.7 2.6 2 1 0 2 2 2 1 zinc-RING finger domain Prok-RING_4 PF14447.6 EDO15935.1 - 9.7e-05 22.2 14.0 0.00016 21.5 5.4 2.4 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-rbx1 PF12678.7 EDO15935.1 - 0.0065 16.7 6.0 0.0065 16.7 6.0 2.2 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 EDO15935.1 - 0.031 14.3 2.0 0.031 14.3 2.0 1.8 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger HypA PF01155.19 EDO15935.1 - 0.054 13.5 5.4 2.2 8.3 0.1 2.4 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DZR PF12773.7 EDO15935.1 - 0.073 13.1 11.4 0.85 9.7 0.2 2.9 2 1 0 2 2 2 0 Double zinc ribbon MSC PF09402.10 EDO15935.1 - 0.11 11.9 2.4 0.2 11.0 2.4 1.4 1 0 0 1 1 1 0 Man1-Src1p-C-terminal domain Zn-ribbon_8 PF09723.10 EDO15935.1 - 0.26 11.4 8.5 1.7 8.8 0.8 2.9 2 0 0 2 2 2 0 Zinc ribbon domain Paired_CXXCH_1 PF09699.10 EDO15935.1 - 1.1 9.0 5.8 6.3 6.6 0.2 3.1 3 0 0 3 3 3 0 Doubled CXXCH motif (Paired_CXXCH_1) zinc_ribbon_4 PF13717.6 EDO15935.1 - 2.5 8.1 5.5 90 3.1 0.2 3.6 3 0 0 3 3 3 0 zinc-ribbon domain zf-RING_4 PF14570.6 EDO15935.1 - 3.1 7.7 17.0 2.9 7.8 6.9 3.0 2 2 0 2 2 2 0 RING/Ubox like zinc-binding domain FANCL_C PF11793.8 EDO15935.1 - 6.5 7.0 10.4 25 5.2 8.0 2.7 2 1 0 2 2 2 0 FANCL C-terminal domain RNHCP PF12647.7 EDO15935.1 - 9.1 6.3 11.3 12 6.0 0.5 2.9 2 1 0 2 2 2 0 RNHCP domain COX7a PF02238.15 EDO15936.1 - 6.3e-24 84.1 0.3 7e-24 84.0 0.3 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VII PDR_assoc PF08370.11 EDO15937.1 - 0.04 13.7 0.0 0.085 12.6 0.0 1.5 1 0 0 1 1 1 0 Plant PDR ABC transporter associated zf-RING_2 PF13639.6 EDO15938.1 - 4.7e-07 30.0 7.7 1.8e-06 28.1 7.7 2.1 1 0 0 1 1 1 1 Ring finger domain FANCL_C PF11793.8 EDO15938.1 - 3.7e-05 23.8 5.8 0.00014 22.0 5.8 1.9 1 1 0 1 1 1 1 FANCL C-terminal domain zf-ANAPC11 PF12861.7 EDO15938.1 - 4.9e-05 23.3 1.3 0.00016 21.7 1.3 1.9 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.7 EDO15938.1 - 0.00031 20.9 7.0 0.00031 20.9 7.0 2.1 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-RING-like PF08746.11 EDO15938.1 - 0.062 13.6 7.2 0.2 12.0 7.2 2.0 1 0 0 1 1 1 0 RING-like domain RINGv PF12906.7 EDO15938.1 - 0.091 12.9 5.9 0.21 11.8 5.9 1.7 1 0 0 1 1 1 0 RING-variant domain zf-RING_4 PF14570.6 EDO15938.1 - 0.18 11.6 8.6 0.37 10.6 0.9 3.2 3 0 0 3 3 3 0 RING/Ubox like zinc-binding domain Zn_ribbon_17 PF17120.5 EDO15938.1 - 0.2 11.3 4.1 0.66 9.6 4.1 1.8 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-C3HC4_2 PF13923.6 EDO15938.1 - 0.5 10.3 10.6 0.43 10.5 7.3 2.6 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EDO15938.1 - 1.3 9.0 12.3 0.42 10.5 0.2 3.0 2 1 1 3 3 3 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EDO15938.1 - 2.2 8.2 6.4 3.4 7.6 0.4 3.0 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.25 EDO15938.1 - 5.8 6.9 18.3 0.09 12.7 7.8 2.7 3 0 0 3 3 2 0 Zinc finger, C3HC4 type (RING finger) Glyco_transf_8 PF01501.20 EDO15939.1 - 7.7e-06 25.6 9.4 8.1e-05 22.3 4.3 3.0 3 0 0 3 3 3 2 Glycosyl transferase family 8 Nucleoside_tran PF01733.18 EDO15939.1 - 0.018 14.5 0.4 0.031 13.7 0.4 1.3 1 0 0 1 1 1 0 Nucleoside transporter AMP-binding PF00501.28 EDO15940.1 - 2.3e-87 293.4 0.0 3.2e-87 292.8 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EDO15940.1 - 0.11 13.5 0.0 1 10.4 0.0 2.6 3 0 0 3 3 3 0 AMP-binding enzyme C-terminal domain Ribosomal_S3_C PF00189.20 EDO15941.1 - 5.7e-23 81.2 0.5 3.1e-22 78.9 0.6 2.0 2 0 0 2 2 2 1 Ribosomal protein S3, C-terminal domain KH_2 PF07650.17 EDO15941.1 - 1.2e-12 47.5 0.5 6e-12 45.2 0.1 2.3 3 0 0 3 3 3 1 KH domain SHR3_chaperone PF08229.11 EDO15942.1 - 1.2e-76 255.9 0.5 1.5e-76 255.6 0.5 1.1 1 0 0 1 1 1 1 ER membrane protein SH3 MARVEL PF01284.23 EDO15942.1 - 0.061 13.3 4.3 0.2 11.7 4.3 1.8 1 1 0 1 1 1 0 Membrane-associating domain UPF0239 PF06783.11 EDO15942.1 - 0.063 13.5 0.4 0.063 13.5 0.4 1.9 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0239) TMEM208_SND2 PF05620.11 EDO15942.1 - 0.89 9.3 4.1 0.37 10.6 1.0 1.9 2 0 0 2 2 2 0 SRP-independent targeting protein 2/TMEM208 Ribosomal_L22 PF00237.19 EDO15943.1 - 3.4e-21 75.4 0.0 7.8e-21 74.2 0.0 1.6 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e AMPK1_CBM PF16561.5 EDO15944.1 - 3.2e-18 65.7 0.0 7.7e-18 64.5 0.0 1.6 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase CBM_48 PF02922.18 EDO15944.1 - 0.00063 20.0 0.0 0.0015 18.8 0.0 1.6 1 0 0 1 1 1 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) Nop14 PF04147.12 EDO15944.1 - 0.067 11.4 25.1 0.091 11.0 25.1 1.1 1 0 0 1 1 1 0 Nop14-like family Suf PF05843.14 EDO15944.1 - 0.93 9.4 15.5 1.4 8.8 15.5 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Hid1 PF12722.7 EDO15944.1 - 5.5 5.0 19.5 7.7 4.5 19.5 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein CAML PF14963.6 EDO15945.1 - 1.8 8.7 6.9 0.13 12.4 1.5 1.7 2 0 0 2 2 2 0 Calcium signal-modulating cyclophilin ligand RIFIN PF02009.16 EDO15946.1 - 0.0036 17.2 6.2 0.0052 16.7 6.2 1.3 1 0 0 1 1 1 1 Rifin SelP_N PF04592.14 EDO15946.1 - 0.024 14.0 15.2 0.036 13.5 15.2 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Endostatin PF06482.11 EDO15946.1 - 0.045 13.2 6.3 0.065 12.7 6.3 1.2 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin T2SSM PF04612.12 EDO15946.1 - 0.11 12.6 1.6 0.16 12.0 1.6 1.2 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein M Zip PF02535.22 EDO15946.1 - 0.18 11.0 5.7 0.24 10.6 5.7 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter TCP PF03634.13 EDO15946.1 - 0.33 11.5 12.3 0.58 10.7 12.3 1.3 1 0 0 1 1 1 0 TCP family transcription factor ATAD4 PF15321.6 EDO15946.1 - 1.9 9.9 11.7 4 8.8 11.7 1.5 1 0 0 1 1 1 0 ATPase family AAA domain containing 4 Band_3_cyto PF07565.13 EDO15946.1 - 4.8 6.9 10.6 8 6.2 10.6 1.3 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Presenilin PF01080.17 EDO15946.1 - 5.8 5.6 11.3 8.4 5.0 11.3 1.2 1 0 0 1 1 1 0 Presenilin HEAT PF02985.22 EDO15947.1 - 3.9e-32 107.5 12.4 0.004 17.3 0.0 12.6 13 1 1 14 14 14 9 HEAT repeat HEAT_2 PF13646.6 EDO15947.1 - 1.6e-18 66.8 0.0 2.5e-06 27.8 0.0 7.7 4 3 4 8 8 8 4 HEAT repeats Cnd1 PF12717.7 EDO15947.1 - 4.8e-09 36.5 16.2 0.0084 16.2 0.8 5.4 3 1 2 5 5 5 3 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 EDO15947.1 - 7.3e-08 32.9 10.7 0.15 12.7 0.3 6.7 3 2 5 8 8 8 2 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.6 EDO15947.1 - 6.2e-05 23.4 8.7 4.7 7.8 0.0 7.4 8 0 0 8 8 8 1 HEAT-like repeat IFRD PF05004.13 EDO15947.1 - 0.0003 20.0 0.8 0.0011 18.2 0.2 2.2 2 1 0 2 2 2 1 Interferon-related developmental regulator (IFRD) Arm PF00514.23 EDO15947.1 - 1.4 9.0 9.5 74 3.6 0.0 5.8 7 0 0 7 7 7 0 Armadillo/beta-catenin-like repeat SNARE PF05739.19 EDO15949.1 - 2e-07 30.9 2.6 2.6e-07 30.5 0.6 2.1 2 0 0 2 2 2 1 SNARE domain Use1 PF09753.9 EDO15949.1 - 1.9e-05 24.5 4.1 2.5e-05 24.1 4.1 1.2 1 0 0 1 1 1 1 Membrane fusion protein Use1 ARGLU PF15346.6 EDO15949.1 - 0.29 11.0 5.0 0.56 10.1 5.0 1.4 1 0 0 1 1 1 0 Arginine and glutamate-rich 1 MHC_II_beta PF00969.19 EDO15949.1 - 0.3 11.2 3.5 1.1 9.4 0.8 2.9 1 1 1 2 2 2 0 Class II histocompatibility antigen, beta domain Turandot PF07240.11 EDO15949.1 - 0.7 9.9 3.3 3.9 7.5 0.2 2.7 2 1 0 2 2 2 0 Stress-inducible humoral factor Turandot Sds3 PF08598.11 EDO15950.1 - 1.5e-52 178.8 1.0 1.5e-52 178.8 1.0 2.8 2 1 0 2 2 2 1 Sds3-like SF3a60_bindingd PF12108.8 EDO15950.1 - 0.44 10.5 2.2 4.3 7.3 0.0 3.0 3 0 0 3 3 3 0 Splicing factor SF3a60 binding domain Cys_Met_Meta_PP PF01053.20 EDO15951.1 - 2.2e-145 484.0 0.0 2.5e-145 483.8 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Met_gamma_lyase PF06838.11 EDO15951.1 - 5.1e-05 22.0 0.0 6.8e-05 21.6 0.0 1.2 1 0 0 1 1 1 1 Methionine gamma-lyase Aminotran_1_2 PF00155.21 EDO15951.1 - 0.0054 15.9 0.0 0.0081 15.4 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 EDO15951.1 - 0.039 12.9 0.1 0.099 11.6 0.0 1.7 2 0 0 2 2 2 0 Aminotransferase class-V Beta_elim_lyase PF01212.21 EDO15951.1 - 0.099 11.9 0.0 2.5 7.3 0.0 2.1 2 0 0 2 2 2 0 Beta-eliminating lyase DUF775 PF05603.12 EDO15952.1 - 1.3e-61 207.6 0.0 1.5e-61 207.4 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF775) tRNA-synt_1c PF00749.21 EDO15953.1 - 1.1e-110 369.4 0.0 1.6e-110 368.9 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain Flu_B_M2 PF04772.12 EDO15953.1 - 0.048 13.9 0.6 0.17 12.1 0.1 2.1 2 0 0 2 2 2 0 Influenza B matrix protein 2 (BM2) AAA_23 PF13476.6 EDO15954.1 - 2.4e-18 67.4 9.3 2.4e-18 67.4 9.3 6.1 3 2 3 6 6 6 1 AAA domain SMC_N PF02463.19 EDO15954.1 - 3.5e-17 62.6 38.4 1.1e-16 60.9 38.4 2.0 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EDO15954.1 - 3.4e-06 27.1 26.2 0.00013 21.9 2.7 3.8 2 2 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 EDO15954.1 - 0.00011 22.0 32.2 0.00011 22.0 32.2 4.1 1 1 3 4 4 4 1 AAA ATPase domain AAA_29 PF13555.6 EDO15954.1 - 0.0011 18.6 0.0 0.0028 17.4 0.0 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain DASH_Dad3 PF08656.10 EDO15954.1 - 0.024 14.7 0.7 0.024 14.7 0.7 4.0 3 2 0 4 4 4 0 DASH complex subunit Dad3 AAA_25 PF13481.6 EDO15954.1 - 0.028 14.0 0.0 0.072 12.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_27 PF13514.6 EDO15954.1 - 0.61 9.6 0.0 0.61 9.6 0.0 3.3 3 1 0 3 3 3 0 AAA domain CLP1_P PF16575.5 EDO15955.1 - 5.6e-27 94.8 0.0 1.1e-26 93.8 0.0 1.6 1 1 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop G-alpha PF00503.20 EDO15955.1 - 2.4e-05 23.6 0.4 9.7e-05 21.7 0.0 2.0 2 0 0 2 2 2 1 G-protein alpha subunit AAA PF00004.29 EDO15956.1 - 2.6e-93 309.4 0.0 2.1e-47 160.8 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EDO15956.1 - 5.6e-21 74.1 0.1 2.5e-09 36.8 0.0 2.7 2 0 0 2 2 2 2 AAA+ lid domain RuvB_N PF05496.12 EDO15956.1 - 3.8e-14 52.7 0.0 7.6e-07 29.0 0.0 2.7 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EDO15956.1 - 3.6e-13 50.2 0.3 9e-05 22.9 0.0 3.7 2 2 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.6 EDO15956.1 - 2.7e-10 40.7 0.6 0.013 15.8 0.0 4.8 2 2 1 3 3 3 2 AAA domain AAA_33 PF13671.6 EDO15956.1 - 4.5e-10 39.9 0.0 0.00034 20.8 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_2 PF07724.14 EDO15956.1 - 6.2e-10 39.5 0.0 0.00094 19.3 0.0 2.9 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 EDO15956.1 - 1.8e-09 37.7 0.1 0.0021 18.1 0.0 3.5 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 EDO15956.1 - 2.1e-08 34.7 0.0 0.00081 19.9 0.0 3.2 3 0 0 3 3 2 2 AAA domain Vps4_C PF09336.10 EDO15956.1 - 3.3e-08 33.4 0.1 0.00079 19.4 0.1 3.0 2 0 0 2 2 2 2 Vps4 C terminal oligomerisation domain TIP49 PF06068.13 EDO15956.1 - 4.8e-08 32.6 3.3 0.00036 19.9 0.0 3.2 4 0 0 4 4 4 2 TIP49 P-loop domain RNA_helicase PF00910.22 EDO15956.1 - 1.8e-07 31.5 0.0 0.013 15.8 0.0 2.8 2 0 0 2 2 2 2 RNA helicase AAA_14 PF13173.6 EDO15956.1 - 3.7e-07 30.2 0.0 0.057 13.5 0.0 3.2 4 0 0 4 4 2 2 AAA domain ABC_tran PF00005.27 EDO15956.1 - 3.7e-07 30.7 0.4 0.032 14.7 0.0 3.2 3 0 0 3 3 3 2 ABC transporter Zeta_toxin PF06414.12 EDO15956.1 - 8e-07 28.5 0.0 0.045 13.0 0.0 2.5 2 0 0 2 2 2 2 Zeta toxin IstB_IS21 PF01695.17 EDO15956.1 - 2.5e-06 27.4 0.0 0.042 13.6 0.0 2.5 2 0 0 2 2 2 2 IstB-like ATP binding protein Mg_chelatase PF01078.21 EDO15956.1 - 4.5e-06 26.2 0.4 0.051 13.0 0.0 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_28 PF13521.6 EDO15956.1 - 5.9e-06 26.6 0.0 0.069 13.4 0.0 2.5 2 0 0 2 2 2 2 AAA domain Rad17 PF03215.15 EDO15956.1 - 9.9e-06 25.6 0.0 0.038 13.9 0.0 2.5 2 0 0 2 2 2 2 Rad17 P-loop domain AAA_3 PF07726.11 EDO15956.1 - 1e-05 25.4 0.0 0.059 13.2 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) SRPRB PF09439.10 EDO15956.1 - 5.9e-05 22.6 0.0 1.6 8.1 0.0 3.6 3 0 0 3 3 3 1 Signal recognition particle receptor beta subunit Cytidylate_kin2 PF13189.6 EDO15956.1 - 6.5e-05 23.1 0.0 0.0039 17.3 0.0 2.7 3 0 0 3 3 2 1 Cytidylate kinase-like family TsaE PF02367.17 EDO15956.1 - 7.9e-05 22.6 0.0 0.61 10.1 0.0 2.4 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE NACHT PF05729.12 EDO15956.1 - 9.6e-05 22.4 0.1 0.62 10.0 0.0 3.0 3 0 0 3 3 2 2 NACHT domain AAA_17 PF13207.6 EDO15956.1 - 0.00011 22.7 2.1 0.15 12.5 0.0 3.6 4 0 0 4 4 3 1 AAA domain SKI PF01202.22 EDO15956.1 - 0.00015 21.9 0.0 0.27 11.3 0.0 3.0 2 0 0 2 2 2 1 Shikimate kinase AAA_11 PF13086.6 EDO15956.1 - 0.00017 21.5 5.8 0.6 9.9 0.0 3.4 3 0 0 3 3 3 1 AAA domain AAA_7 PF12775.7 EDO15956.1 - 0.00018 21.0 0.0 0.74 9.3 0.0 3.0 2 0 0 2 2 2 2 P-loop containing dynein motor region Viral_helicase1 PF01443.18 EDO15956.1 - 0.00024 20.9 0.0 0.62 9.8 0.0 2.7 2 0 0 2 2 2 2 Viral (Superfamily 1) RNA helicase Sigma54_activat PF00158.26 EDO15956.1 - 0.00025 20.8 0.0 0.28 10.9 0.0 3.0 3 0 0 3 3 3 1 Sigma-54 interaction domain AAA_25 PF13481.6 EDO15956.1 - 0.00029 20.5 0.1 1.5 8.3 0.0 3.7 4 1 1 5 5 4 1 AAA domain DUF815 PF05673.13 EDO15956.1 - 0.00051 19.3 0.0 0.19 10.9 0.0 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF815) Sigma54_activ_2 PF14532.6 EDO15956.1 - 0.00057 20.0 0.0 2.8 8.0 0.0 3.1 3 0 0 3 3 3 2 Sigma-54 interaction domain AAA_24 PF13479.6 EDO15956.1 - 0.0007 19.4 0.0 0.88 9.3 0.0 2.5 2 0 0 2 2 2 2 AAA domain NB-ARC PF00931.22 EDO15956.1 - 0.00098 18.4 0.0 1 8.5 0.0 3.0 3 0 0 3 3 3 1 NB-ARC domain CPT PF07931.12 EDO15956.1 - 0.0012 18.8 0.0 0.026 14.4 0.0 2.3 2 0 0 2 2 2 1 Chloramphenicol phosphotransferase-like protein ATPase_2 PF01637.18 EDO15956.1 - 0.0015 18.5 0.3 2.4 8.0 0.0 3.5 3 1 1 4 4 3 1 ATPase domain predominantly from Archaea ATPase PF06745.13 EDO15956.1 - 0.0019 17.6 0.1 1.6 8.0 0.0 3.2 3 0 0 3 3 3 1 KaiC Parvo_NS1 PF01057.17 EDO15956.1 - 0.0027 16.8 0.0 2 7.4 0.0 2.3 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 Cytidylate_kin PF02224.18 EDO15956.1 - 0.0077 16.0 0.1 0.56 9.9 0.0 2.6 2 0 0 2 2 2 1 Cytidylate kinase AAA_19 PF13245.6 EDO15956.1 - 0.013 15.8 0.0 3.6 7.9 0.0 2.6 2 0 0 2 2 2 0 AAA domain PduV-EutP PF10662.9 EDO15956.1 - 0.016 14.9 0.0 7.8 6.2 0.0 2.6 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation PhoH PF02562.16 EDO15956.1 - 0.021 14.3 0.1 2.9 7.3 0.0 2.4 2 0 0 2 2 2 0 PhoH-like protein AFG1_ATPase PF03969.16 EDO15956.1 - 0.03 13.2 0.0 7.7 5.3 0.0 2.5 2 0 0 2 2 2 0 AFG1-like ATPase NTPase_1 PF03266.15 EDO15956.1 - 0.047 13.6 0.0 12 5.7 0.0 2.5 2 0 0 2 2 2 0 NTPase hSac2 PF12456.8 EDO15956.1 - 0.063 13.0 0.6 0.13 12.0 0.6 1.5 1 0 0 1 1 1 0 Inositol phosphatase FeoB_N PF02421.18 EDO15956.1 - 0.067 12.7 0.1 2 7.9 0.0 2.5 2 0 0 2 2 2 0 Ferrous iron transport protein B RsgA_GTPase PF03193.16 EDO15956.1 - 0.069 13.1 0.0 0.88 9.5 0.0 2.4 2 0 0 2 2 2 0 RsgA GTPase TniB PF05621.11 EDO15956.1 - 0.081 12.3 0.0 18 4.7 0.0 2.6 2 0 0 2 2 2 0 Bacterial TniB protein MMR_HSR1 PF01926.23 EDO15956.1 - 0.094 12.8 0.2 3.3 7.8 0.0 2.9 2 0 0 2 2 2 0 50S ribosome-binding GTPase IPT PF01745.16 EDO15956.1 - 0.11 11.8 1.0 24 4.2 0.0 3.0 3 0 0 3 3 3 0 Isopentenyl transferase Hydin_ADK PF17213.3 EDO15956.1 - 0.15 12.3 8.3 0.76 10.0 0.0 3.2 3 0 0 3 3 3 0 Hydin Adenylate kinase-like domain AAA_30 PF13604.6 EDO15956.1 - 0.16 11.7 0.1 18 5.0 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.6 EDO15956.1 - 1.1 9.7 0.0 1.1 9.7 0.0 4.1 3 1 0 3 3 2 0 AAA domain DUF2456 PF10445.9 EDO15957.1 - 2.9e-37 126.6 5.2 6.6e-37 125.5 5.2 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2456) YxiJ PF14176.6 EDO15957.1 - 0.027 14.9 0.8 2 9.0 0.1 2.3 2 0 0 2 2 2 0 YxiJ-like protein FtsX PF02687.21 EDO15957.1 - 0.028 14.9 8.0 1.2 9.7 1.0 2.3 2 0 0 2 2 2 0 FtsX-like permease family DUF5401 PF17380.2 EDO15958.1 - 0.99 7.4 28.8 1.8 6.5 28.8 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5401) Caldesmon PF02029.15 EDO15958.1 - 6 5.5 40.6 0.12 11.1 34.1 1.5 2 0 0 2 2 2 0 Caldesmon Creatinase_N_2 PF16189.5 EDO15960.1 - 3.9e-41 140.8 0.2 1.3e-40 139.2 0.2 1.8 2 0 0 2 2 2 1 Creatinase/Prolidase N-terminal domain Creatinase_N PF01321.18 EDO15960.1 - 1.4e-08 35.5 0.0 3e-08 34.4 0.0 1.6 1 0 0 1 1 1 1 Creatinase/Prolidase N-terminal domain MFS_1 PF07690.16 EDO15961.1 - 6.1e-36 124.1 23.0 6.1e-36 124.1 23.0 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EDO15961.1 - 9.3e-06 24.3 4.7 2.1e-05 23.2 4.7 1.5 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Fe-S_biosyn PF01521.20 EDO15962.1 - 7.4e-20 71.2 0.0 2.2e-19 69.7 0.0 1.8 2 1 0 2 2 2 1 Iron-sulphur cluster biosynthesis DNA_binding_2 PF13724.6 EDO15962.1 - 6.2 7.3 7.5 0.35 11.3 0.9 2.3 2 0 0 2 2 2 0 DNA-binding domain NPR3 PF03666.13 EDO15963.1 - 2.4e-166 554.1 3.6 2.4e-166 554.1 3.6 2.5 2 1 0 2 2 2 1 Nitrogen Permease regulator of amino acid transport activity 3 Curto_V2 PF07325.11 EDO15963.1 - 0.19 11.6 1.8 0.31 10.9 0.3 2.1 2 0 0 2 2 2 0 Curtovirus V2 protein UCH PF00443.29 EDO15964.1 - 1.4e-52 178.8 2.4 3.2e-52 177.6 2.4 1.6 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EDO15964.1 - 1.7e-17 64.0 13.3 4.9e-17 62.5 6.3 2.9 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase TF_Zn_Ribbon PF08271.12 EDO15964.1 - 0.034 13.7 0.6 12 5.5 0.0 2.8 2 0 0 2 2 2 0 TFIIB zinc-binding zf-BED PF02892.15 EDO15964.1 - 0.048 13.7 1.4 13 5.9 0.4 2.7 2 0 0 2 2 2 0 BED zinc finger Ribosomal_L11 PF00298.19 EDO15965.1 - 2.6e-28 98.3 0.6 3.8e-28 97.8 0.6 1.3 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain Ribosomal_L11_N PF03946.14 EDO15965.1 - 2.9e-26 91.1 0.2 5.3e-26 90.2 0.2 1.4 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Pkinase PF00069.25 EDO15966.1 - 9.9e-46 156.2 0.0 1.6e-45 155.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO15966.1 - 2.2e-21 76.4 0.0 4.1e-21 75.4 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EDO15966.1 - 0.024 13.6 0.2 0.024 13.6 0.2 2.8 3 0 0 3 3 3 0 Haspin like kinase domain Kinase-like PF14531.6 EDO15966.1 - 0.12 11.7 0.0 0.2 11.0 0.0 1.4 1 0 0 1 1 1 0 Kinase-like ANAPC4_WD40 PF12894.7 EDO15967.1 - 0.00017 21.9 0.2 0.0081 16.4 0.0 3.5 5 0 0 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EDO15967.1 - 0.0036 18.1 0.2 16 6.6 0.0 3.8 3 0 0 3 3 3 2 WD domain, G-beta repeat PQQ_3 PF13570.6 EDO15967.1 - 0.0065 16.9 0.3 4 8.0 0.0 3.8 3 0 0 3 3 3 1 PQQ-like domain DASH_Dam1 PF08653.10 EDO15967.1 - 0.27 11.1 1.9 0.41 10.5 0.6 2.0 2 0 0 2 2 2 0 DASH complex subunit Dam1 Bap31_Bap29_C PF18035.1 EDO15967.1 - 0.3 11.1 2.1 0.77 9.8 2.1 1.6 1 0 0 1 1 1 0 Bap31/Bap29 cytoplasmic coiled-coil domain adh_short PF00106.25 EDO15968.1 - 4.3e-09 36.1 0.0 2.2e-08 33.8 0.0 2.0 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 EDO15968.1 - 9.7e-07 28.6 0.0 1.8e-06 27.7 0.0 1.4 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EDO15968.1 - 9e-06 25.7 0.0 1.5e-05 25.0 0.0 1.3 1 0 0 1 1 1 1 KR domain Cation_efflux PF01545.21 EDO15969.1 - 7.7e-55 185.7 12.0 1.6e-54 184.7 12.0 1.5 1 1 0 1 1 1 1 Cation efflux family Zip PF02535.22 EDO15969.1 - 0.0001 21.7 2.2 0.00015 21.1 2.2 1.3 1 0 0 1 1 1 1 ZIP Zinc transporter Neur_chan_memb PF02932.16 EDO15969.1 - 0.32 11.0 3.2 9.1 6.3 2.9 2.8 2 1 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region DUF1091 PF06477.13 EDO15970.1 - 0.23 11.9 5.0 0.53 10.8 1.5 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1091) Ribosomal_L18A PF01775.17 EDO15972.1 - 7.8e-44 148.6 3.3 1.1e-43 148.2 3.3 1.2 1 0 0 1 1 1 1 Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A LRR_6 PF13516.6 EDO15974.1 - 0.025 14.6 6.3 11 6.4 0.0 5.2 5 0 0 5 5 5 0 Leucine Rich repeat LRR_4 PF12799.7 EDO15974.1 - 0.086 13.3 18.0 0.55 10.7 0.2 5.8 6 1 1 7 7 7 0 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EDO15974.1 - 0.51 11.1 5.4 3.2e+02 2.6 0.0 6.2 6 1 0 6 6 6 0 Leucine Rich Repeat LRR_8 PF13855.6 EDO15974.1 - 1.3 8.9 10.5 1.6 8.6 0.1 4.6 4 0 0 4 4 4 0 Leucine rich repeat Pkinase PF00069.25 EDO15975.1 - 8.8e-68 228.5 0.0 1.1e-67 228.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO15975.1 - 4.4e-33 114.7 0.0 6.2e-33 114.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDO15975.1 - 0.00029 20.2 0.0 0.00049 19.5 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 EDO15975.1 - 0.00098 18.2 0.2 0.0016 17.4 0.2 1.3 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 EDO15975.1 - 0.009 15.4 0.1 0.016 14.6 0.1 1.4 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pox_VLTF3 PF04947.14 EDO15975.1 - 0.018 14.8 3.1 0.046 13.4 3.1 1.7 1 0 0 1 1 1 0 Poxvirus Late Transcription Factor VLTF3 like FTA2 PF13095.6 EDO15975.1 - 0.046 13.3 0.1 0.1 12.2 0.1 1.6 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 EDO15975.1 - 0.1 12.5 0.1 0.37 10.7 0.1 1.8 1 1 1 2 2 2 0 Phosphotransferase enzyme family CN_hydrolase PF00795.22 EDO15976.1 - 4.2e-63 213.1 0.0 4.7e-63 213.0 0.0 1.0 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase ORMDL PF04061.14 EDO15977.1 - 1e-54 184.0 6.1 1.3e-54 183.7 6.1 1.1 1 0 0 1 1 1 1 ORMDL family Dscam_C PF12355.8 EDO15977.1 - 0.094 13.7 2.5 0.13 13.2 2.5 1.2 1 0 0 1 1 1 0 Down syndrome cell adhesion molecule C terminal ACBP PF00887.19 EDO15978.1 - 5.8e-28 96.9 0.2 6.4e-28 96.8 0.2 1.0 1 0 0 1 1 1 1 Acyl CoA binding protein HEAT PF02985.22 EDO15979.1 - 5.2e-12 44.9 20.9 0.0019 18.3 0.1 9.8 11 0 0 11 11 11 3 HEAT repeat HEAT_EZ PF13513.6 EDO15979.1 - 5.9e-12 45.8 6.5 1.8e-08 34.7 0.0 7.5 9 1 0 9 9 8 1 HEAT-like repeat IBN_N PF03810.19 EDO15979.1 - 7.6e-08 32.2 7.5 1.9e-07 30.9 3.8 3.1 2 0 0 2 2 2 1 Importin-beta N-terminal domain HEAT_2 PF13646.6 EDO15979.1 - 5.6e-06 26.7 0.2 0.29 11.6 0.0 5.6 4 2 3 7 7 7 2 HEAT repeats Sec7_N PF12783.7 EDO15979.1 - 0.00036 20.5 2.7 0.19 11.6 0.6 4.1 3 2 0 3 3 3 1 Guanine nucleotide exchange factor in Golgi transport N-terminal Arm PF00514.23 EDO15979.1 - 0.00069 19.6 3.6 0.028 14.5 0.0 4.1 4 0 0 4 4 4 1 Armadillo/beta-catenin-like repeat TIP120 PF08623.10 EDO15979.1 - 0.00079 19.2 4.0 1.3 8.7 1.0 3.7 2 1 0 2 2 2 1 TATA-binding protein interacting (TIP20) CLASP_N PF12348.8 EDO15979.1 - 0.0043 16.6 8.8 0.15 11.6 0.0 4.8 5 1 0 6 6 6 1 CLASP N terminal RIX1 PF08167.12 EDO15979.1 - 0.024 14.4 1.6 0.84 9.3 0.3 4.0 4 1 1 5 5 5 0 rRNA processing/ribosome biogenesis Telomere_reg-2 PF10193.9 EDO15979.1 - 0.11 13.0 6.0 0.28 11.6 0.1 3.6 3 1 1 4 4 3 0 Telomere length regulation protein Vac14_Fab1_bd PF12755.7 EDO15979.1 - 0.53 10.9 6.1 4.2 8.0 0.0 4.7 5 0 0 5 5 5 0 Vacuolar 14 Fab1-binding region RTP1_C1 PF10363.9 EDO15979.1 - 0.9 9.7 5.1 11 6.3 0.9 4.6 4 2 1 5 5 5 0 Required for nuclear transport of RNA pol II C-terminus 1 TetR_C_37 PF18665.1 EDO15979.1 - 1.2 9.7 6.7 0.29 11.8 0.5 3.0 3 1 1 4 4 2 0 Tetracyclin repressor-like, C-terminal domain PAP2 PF01569.21 EDO15980.1 - 2.1e-19 69.6 0.5 3.7e-19 68.8 0.5 1.4 1 0 0 1 1 1 1 PAP2 superfamily DUF212 PF02681.14 EDO15980.1 - 0.072 13.2 0.2 1.4 9.1 0.0 2.2 1 1 1 2 2 2 0 Divergent PAP2 family 6PF2K PF01591.18 EDO15981.1 - 1.3e-59 201.2 6.6 1.9e-59 200.6 6.6 1.2 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 EDO15981.1 - 1.1e-18 67.6 0.0 2.1e-18 66.7 0.0 1.5 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.6 EDO15981.1 - 0.00017 21.7 0.0 0.0003 21.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain DUF5426 PF17473.2 EDO15981.1 - 0.36 11.1 5.9 0.16 12.2 2.9 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5426) Ribosomal_L26 PF16906.5 EDO15982.1 - 2.6e-37 127.1 1.4 3.6e-37 126.7 1.4 1.2 1 0 0 1 1 1 1 Ribosomal proteins L26 eukaryotic, L24P archaeal KOW PF00467.29 EDO15982.1 - 3e-05 23.8 2.6 7e-05 22.6 2.2 2.0 1 1 0 1 1 1 1 KOW motif TIM21 PF08294.11 EDO15983.1 - 1.8e-56 190.1 0.0 2.4e-56 189.6 0.0 1.2 1 0 0 1 1 1 1 TIM21 Glucan_synthase PF02364.15 EDO15984.1 - 0 1346.4 0.0 0 1346.0 0.0 1.2 1 0 0 1 1 1 1 1,3-beta-glucan synthase component FKS1_dom1 PF14288.6 EDO15984.1 - 4.9e-43 146.6 0.4 1.4e-42 145.1 0.4 1.9 1 0 0 1 1 1 1 1,3-beta-glucan synthase subunit FKS1, domain-1 Alba PF01918.21 EDO15985.1 - 2.5e-15 56.0 1.3 4.8e-15 55.1 1.3 1.5 1 0 0 1 1 1 1 Alba DUF4889 PF16230.5 EDO15985.1 - 1.6 9.0 6.9 0.14 12.4 1.5 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4889) WH2 PF02205.20 EDO15986.1 - 8.4e-16 57.2 0.7 3.5e-09 36.2 0.5 3.2 2 0 0 2 2 2 2 WH2 motif MA3 PF02847.17 EDO15987.1 - 1.6e-26 92.5 1.6 3.1e-26 91.6 0.2 2.4 2 0 0 2 2 2 1 MA3 domain MIF4G PF02854.19 EDO15987.1 - 1e-17 64.5 4.9 3.7e-17 62.7 4.9 2.1 1 0 0 1 1 1 1 MIF4G domain Nas2_N PF18265.1 EDO15989.1 - 1.6e-20 72.7 1.4 4.1e-20 71.5 1.4 1.7 1 0 0 1 1 1 1 Nas2 N_terminal domain GRASP55_65 PF04495.14 EDO15989.1 - 7.1e-07 29.6 0.1 1.6e-06 28.5 0.1 1.5 1 1 0 1 1 1 1 GRASP55/65 PDZ-like domain PDZ PF00595.24 EDO15989.1 - 0.00049 20.4 0.2 0.00079 19.7 0.2 1.4 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 EDO15989.1 - 0.0036 17.1 0.0 0.0076 16.1 0.0 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 EDO15989.1 - 0.0058 16.9 0.4 0.017 15.4 0.0 1.9 2 0 0 2 2 2 1 PDZ domain FlgN PF05130.12 EDO15989.1 - 0.0095 16.4 6.4 0.014 15.9 6.4 1.2 1 0 0 1 1 1 1 FlgN protein Apolipoprotein PF01442.18 EDO15989.1 - 0.018 14.9 0.4 3.7 7.4 0.5 2.1 2 0 0 2 2 2 0 Apolipoprotein A1/A4/E domain FAA_hydrolase_N PF09298.11 EDO15989.1 - 0.023 14.9 2.8 2 8.6 0.0 3.0 2 1 0 3 3 3 0 Fumarylacetoacetase N-terminal Herpes_BBRF1 PF04793.12 EDO15989.1 - 0.11 11.5 2.2 0.11 11.6 0.8 1.5 2 0 0 2 2 2 0 BRRF1-like protein YlqD PF11068.8 EDO15989.1 - 0.12 12.7 3.1 0.2 12.0 3.1 1.4 1 0 0 1 1 1 0 YlqD protein Baculo_PEP_C PF04513.12 EDO15989.1 - 0.14 12.2 8.0 1.3 9.1 8.0 2.2 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Ribosomal_L12_N PF16320.5 EDO15989.1 - 0.22 11.3 2.3 0.52 10.1 2.3 1.7 1 0 0 1 1 1 0 Ribosomal protein L7/L12 dimerisation domain SirA PF10747.9 EDO15989.1 - 0.49 10.7 10.8 0.045 14.1 4.8 2.1 2 1 0 2 2 2 0 Sporulation inhibitor of replication protein SirA Muted PF14942.6 EDO15989.1 - 0.59 10.5 8.5 4.4 7.6 2.2 2.4 2 0 0 2 2 2 0 Organelle biogenesis, Muted-like protein DUF4404 PF14357.6 EDO15989.1 - 0.72 10.5 5.3 1.2 9.9 2.5 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4404) DUF1664 PF07889.12 EDO15989.1 - 0.92 9.6 5.4 8.4 6.5 1.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) DNA_primase_lrg PF04104.14 EDO15989.1 - 6.6 6.1 7.5 2.5 7.4 1.2 2.1 1 1 1 2 2 2 0 Eukaryotic and archaeal DNA primase, large subunit Thioredoxin PF00085.20 EDO15990.1 - 4.2e-23 81.3 0.2 4.4e-16 58.7 0.0 4.2 4 0 0 4 4 4 3 Thioredoxin OAD_gamma PF04277.13 EDO15990.1 - 1.2 9.7 2.5 2.5 8.7 2.5 1.5 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain Mei5_like PF17021.5 EDO15991.1 - 0.11 12.5 6.9 0.032 14.3 1.6 2.7 1 1 0 2 2 2 0 Putative double-strand recombination repair-like DUF4611 PF15387.6 EDO15991.1 - 0.13 12.5 0.1 0.13 12.5 0.1 3.3 5 0 0 5 5 5 0 Domain of unknown function (DUF4611) Tup_N PF08581.10 EDO15991.1 - 0.33 11.3 5.3 2.5 8.5 0.9 3.0 2 0 0 2 2 2 0 Tup N-terminal Prefoldin_2 PF01920.20 EDO15992.1 - 1e-20 73.6 5.0 1.1e-20 73.5 5.0 1.0 1 0 0 1 1 1 1 Prefoldin subunit DUF3010 PF11215.8 EDO15992.1 - 0.12 12.6 1.8 10 6.4 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3010) DDOST_48kD PF03345.14 EDO15993.1 - 1.4e-127 426.0 6.6 1.7e-127 425.8 6.6 1.0 1 0 0 1 1 1 1 Oligosaccharyltransferase 48 kDa subunit beta BTB PF00651.31 EDO15994.1 - 3.3e-12 46.6 1.5 3.7e-09 36.8 0.1 2.8 2 1 0 2 2 2 2 BTB/POZ domain Ank_2 PF12796.7 EDO15994.1 - 4.8e-07 30.3 0.0 1.7e-06 28.5 0.0 1.9 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EDO15994.1 - 5.7e-06 26.8 0.1 2.1e-05 25.0 0.1 2.0 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.30 EDO15994.1 - 0.0019 18.6 0.0 0.0093 16.4 0.0 2.3 1 0 0 1 1 1 1 Ankyrin repeat Ank_3 PF13606.6 EDO15994.1 - 0.0021 18.4 0.2 0.03 14.9 0.0 3.0 2 0 0 2 2 2 1 Ankyrin repeat Ank_5 PF13857.6 EDO15994.1 - 0.003 17.8 0.2 0.017 15.4 0.1 2.3 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Post_transc_reg PF13797.6 EDO15994.1 - 0.0085 15.9 0.6 0.028 14.3 0.1 2.1 2 0 0 2 2 2 1 Post-transcriptional regulator DUF4500 PF14937.6 EDO15995.1 - 0.12 12.4 0.2 2.9 8.0 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4500) RRM_1 PF00076.22 EDO15996.1 - 7.9e-16 57.6 0.0 1.2e-15 57.1 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM PF05172.13 EDO15996.1 - 0.0076 16.2 0.0 0.011 15.7 0.0 1.2 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif DUF3685 PF12452.8 EDO15996.1 - 0.037 13.7 0.1 0.037 13.7 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3685) Nop16 PF09420.10 EDO15997.1 - 1.4e-68 231.1 15.2 1.9e-68 230.6 15.2 1.2 1 0 0 1 1 1 1 Ribosome biogenesis protein Nop16 GN3L_Grn1 PF08701.11 EDO15998.1 - 4.9e-24 84.2 18.0 1.5e-23 82.7 18.0 1.8 1 0 0 1 1 1 1 GNL3L/Grn1 putative GTPase MMR_HSR1 PF01926.23 EDO15998.1 - 7e-19 68.0 0.1 1.4e-14 54.1 0.0 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase FeoB_N PF02421.18 EDO15998.1 - 2.5e-09 36.8 0.1 3.3e-08 33.2 0.0 2.2 2 0 0 2 2 2 1 Ferrous iron transport protein B Dynamin_N PF00350.23 EDO15998.1 - 5e-06 26.7 0.3 0.23 11.5 0.1 3.6 2 1 1 3 3 3 2 Dynamin family RsgA_GTPase PF03193.16 EDO15998.1 - 4.6e-05 23.4 0.6 0.0013 18.6 0.6 2.4 1 1 0 1 1 1 1 RsgA GTPase GTP_EFTU PF00009.27 EDO15998.1 - 0.00019 21.0 0.1 0.11 12.0 0.0 2.7 2 1 0 2 2 2 2 Elongation factor Tu GTP binding domain AIG1 PF04548.16 EDO15998.1 - 0.00048 19.5 0.1 0.0014 18.0 0.0 1.8 2 0 0 2 2 2 1 AIG1 family MeaB PF03308.16 EDO15998.1 - 0.016 14.2 0.1 0.035 13.1 0.1 1.5 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Roc PF08477.13 EDO15998.1 - 0.039 14.2 0.1 4.1 7.6 0.0 2.7 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_18 PF13238.6 EDO15998.1 - 0.042 14.4 0.2 0.18 12.3 0.0 2.2 2 0 0 2 2 2 0 AAA domain CAP_GLY PF01302.25 EDO15999.1 - 6.4e-15 54.9 0.2 1.1e-14 54.1 0.2 1.4 1 0 0 1 1 1 1 CAP-Gly domain LRR_4 PF12799.7 EDO15999.1 - 1.7e-14 53.7 30.6 2.3e-05 24.6 3.0 5.9 5 1 0 6 6 6 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EDO15999.1 - 1.5e-09 37.4 22.4 6.8e-06 25.8 5.0 4.9 2 1 2 4 4 4 4 Leucine rich repeat LRR_1 PF00560.33 EDO15999.1 - 5.6e-07 29.2 27.9 0.51 11.1 0.4 9.0 9 0 0 9 9 9 3 Leucine Rich Repeat LRR_9 PF14580.6 EDO15999.1 - 2.2e-05 24.1 2.8 0.00024 20.7 0.6 2.5 1 1 1 2 2 2 2 Leucine-rich repeat LRR_6 PF13516.6 EDO15999.1 - 2.2e-05 24.1 21.2 1.7 8.9 0.8 9.1 9 0 0 9 9 9 2 Leucine Rich repeat FNIP PF05725.12 EDO15999.1 - 0.0092 16.1 0.7 0.031 14.4 0.7 2.0 1 0 0 1 1 1 1 FNIP Repeat Pre-PUA PF17832.1 EDO16000.1 - 3.1e-25 88.7 2.5 7.1e-25 87.5 2.6 1.5 2 0 0 2 2 2 1 Pre-PUA-like domain PUA PF01472.20 EDO16000.1 - 1.4e-22 79.4 0.0 2.1e-22 78.9 0.0 1.3 1 0 0 1 1 1 1 PUA domain DUF1947 PF09183.10 EDO16000.1 - 0.00038 20.7 1.1 0.00038 20.7 1.1 2.1 2 1 0 2 2 2 1 Domain of unknown function (DUF1947) DUF4288 PF14119.6 EDO16000.1 - 0.096 13.1 0.0 0.2 12.0 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4288) NTF2 PF02136.20 EDO16001.1 - 8.4e-36 123.2 0.3 9.4e-36 123.0 0.3 1.0 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain DUF4518 PF15008.6 EDO16001.1 - 0.00041 19.6 0.1 0.0011 18.2 0.1 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF4518) DUF4440 PF14534.6 EDO16001.1 - 0.12 12.8 0.0 0.14 12.6 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4440) DnaJ-X PF14308.6 EDO16002.1 - 7.6e-77 257.5 5.1 7.6e-77 257.5 5.1 2.8 1 1 1 2 2 2 1 X-domain of DnaJ-containing DnaJ PF00226.31 EDO16002.1 - 4.2e-23 81.3 3.2 2e-22 79.1 3.2 2.3 1 0 0 1 1 1 1 DnaJ domain SprA-related PF12118.8 EDO16002.1 - 0.86 8.7 14.4 0.65 9.1 12.1 1.9 2 0 0 2 2 2 0 SprA-related family Presenilin PF01080.17 EDO16002.1 - 3.6 6.2 10.3 6.5 5.4 10.3 1.4 1 0 0 1 1 1 0 Presenilin Anoctamin PF04547.12 EDO16002.1 - 5.8 5.6 6.4 10 4.8 6.4 1.4 1 1 0 1 1 1 0 Calcium-activated chloride channel Gcn1_N PF12074.8 EDO16004.1 - 1.3e-24 87.2 6.8 2.4e-12 46.8 0.0 4.1 2 1 1 3 3 3 3 Generalcontrol nonderepressible 1 (Gcn1) N-terminal HEAT_EZ PF13513.6 EDO16004.1 - 1.4e-21 76.5 0.0 0.00023 21.6 0.0 10.1 8 1 2 10 10 10 4 HEAT-like repeat HEAT_2 PF13646.6 EDO16004.1 - 2e-20 72.9 3.3 0.00024 21.4 0.0 8.7 8 1 1 9 9 8 3 HEAT repeats HEAT PF02985.22 EDO16004.1 - 2.1e-20 71.1 5.8 0.012 15.8 0.0 12.8 14 0 0 14 14 13 4 HEAT repeat Cnd1 PF12717.7 EDO16004.1 - 3.9e-07 30.2 10.9 0.075 13.1 0.3 7.4 4 2 2 6 6 6 2 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 EDO16004.1 - 1.4e-06 28.8 0.2 0.61 10.7 0.0 6.3 6 1 0 6 6 6 1 Vacuolar 14 Fab1-binding region Arm PF00514.23 EDO16004.1 - 0.028 14.5 0.3 16 5.7 0.1 4.5 2 0 0 2 2 2 0 Armadillo/beta-catenin-like repeat rhaM PF05336.13 EDO16004.1 - 0.067 13.3 0.7 0.33 11.0 0.3 2.3 2 0 0 2 2 2 0 L-rhamnose mutarotase RICTOR_V PF14668.6 EDO16004.1 - 0.11 12.7 0.0 33 4.8 0.0 3.9 2 0 0 2 2 2 0 Rapamycin-insensitive companion of mTOR, domain 5 Phage_TAC_9 PF10876.8 EDO16004.1 - 0.12 12.4 0.1 13 5.9 0.0 2.8 2 0 0 2 2 2 0 Phage tail assemb.y chaperone protein, TAC Antiterm PF03589.13 EDO16004.1 - 0.4 11.0 1.2 2.8 8.3 0.0 3.1 3 0 0 3 3 2 0 Antitermination protein UPF0147 PF03685.13 EDO16004.1 - 2 8.6 6.5 7.3 6.7 0.0 4.5 4 1 0 4 4 4 0 Uncharacterised protein family (UPF0147) Metallophos PF00149.28 EDO16005.1 - 2.7e-40 139.1 0.1 3.5e-40 138.7 0.1 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 EDO16005.1 - 5.4e-22 78.0 2.8 5.8e-22 77.9 1.2 1.9 2 0 0 2 2 2 1 Serine-threonine protein phosphatase N-terminal domain Acid_PPase PF12689.7 EDO16006.1 - 5.6e-43 146.7 0.0 6.4e-43 146.5 0.0 1.0 1 0 0 1 1 1 1 Acid Phosphatase CheW PF01584.19 EDO16006.1 - 0.022 14.4 0.0 0.035 13.7 0.0 1.3 1 0 0 1 1 1 0 CheW-like domain AAA PF00004.29 EDO16007.1 - 0.023 15.1 0.0 0.071 13.5 0.0 1.9 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Glyco_transf_22 PF03901.17 EDO16008.1 - 5.3e-65 220.3 40.2 6.4e-65 220.0 40.2 1.1 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family TctC PF03401.14 EDO16008.1 - 0.069 12.2 0.0 0.11 11.6 0.0 1.2 1 0 0 1 1 1 0 Tripartite tricarboxylate transporter family receptor CBFD_NFYB_HMF PF00808.23 EDO16009.1 - 3.9e-14 52.7 1.2 6.3e-14 52.0 1.2 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone DUF1340 PF07067.11 EDO16009.1 - 0.05 13.0 0.1 0.067 12.6 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1340) Histone PF00125.24 EDO16009.1 - 0.056 13.8 0.2 0.056 13.8 0.2 1.6 2 0 0 2 2 2 0 Core histone H2A/H2B/H3/H4 RNA_Me_trans PF04252.13 EDO16010.1 - 1.9e-75 252.9 0.0 2.2e-75 252.6 0.0 1.0 1 0 0 1 1 1 1 Predicted SAM-dependent RNA methyltransferase ATP19 PF11022.8 EDO16011.1 - 9.3e-20 70.8 0.1 1e-19 70.7 0.1 1.0 1 0 0 1 1 1 1 ATP synthase subunit K Cpn10 PF00166.21 EDO16012.1 - 2e-27 95.1 0.1 2.3e-27 94.9 0.1 1.0 1 0 0 1 1 1 1 Chaperonin 10 Kd subunit PRP3 PF08572.10 EDO16013.1 - 5e-54 183.4 18.5 9.1e-54 182.5 18.5 1.4 1 0 0 1 1 1 1 pre-mRNA processing factor 3 (PRP3) DUF1115 PF06544.12 EDO16013.1 - 1.7e-30 106.0 1.1 1.7e-30 106.0 1.1 3.5 4 0 0 4 4 4 1 Protein of unknown function (DUF1115) KSHV_K8 PF07188.11 EDO16013.1 - 0.14 11.5 0.0 0.26 10.6 0.0 1.4 1 0 0 1 1 1 0 Kaposi's sarcoma-associated herpesvirus (KSHV) K8 protein DUF2470 PF10615.9 EDO16015.1 - 7e-07 29.8 0.0 1.4e-06 28.9 0.0 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF2470) Pkinase PF00069.25 EDO16016.1 - 1.6e-75 253.9 0.1 1.6e-75 253.9 0.1 1.6 2 0 0 2 2 2 1 Protein kinase domain AdenylateSensor PF16579.5 EDO16016.1 - 1.3e-54 183.6 0.1 3.5e-54 182.3 0.1 1.8 1 0 0 1 1 1 1 Adenylate sensor of SNF1-like protein kinase Pkinase_Tyr PF07714.17 EDO16016.1 - 7.3e-36 123.8 0.0 1.4e-35 122.9 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase UBA_2 PF08587.11 EDO16016.1 - 3e-17 62.5 2.3 3e-17 62.5 2.3 2.2 2 0 0 2 2 2 1 Ubiquitin associated domain (UBA) Kinase-like PF14531.6 EDO16016.1 - 1.8e-11 43.9 0.0 1.3e-10 41.1 0.0 2.2 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 EDO16016.1 - 0.0018 18.3 0.4 0.063 13.2 0.4 2.2 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 EDO16016.1 - 0.012 15.0 0.4 0.02 14.3 0.4 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family SwrA PF17423.2 EDO16016.1 - 0.16 12.0 1.7 1 9.3 0.0 2.6 2 1 0 2 2 2 0 Swarming motility protein SIR2 PF02146.17 EDO16017.1 - 3.3e-37 128.1 0.0 4.4e-22 78.9 0.0 2.4 2 0 0 2 2 2 2 Sir2 family Zn-ribbon_8 PF09723.10 EDO16017.1 - 0.024 14.8 2.7 0.024 14.8 2.7 2.0 2 0 0 2 2 2 0 Zinc ribbon domain Fe_hyd_lg_C PF02906.14 EDO16017.1 - 0.13 11.9 0.0 0.25 11.0 0.0 1.4 1 0 0 1 1 1 0 Iron only hydrogenase large subunit, C-terminal domain Zn_Tnp_IS1595 PF12760.7 EDO16017.1 - 0.8 9.7 5.7 1.3 9.1 1.8 2.5 3 0 0 3 3 3 0 Transposase zinc-ribbon domain bZIP_1 PF00170.21 EDO16019.1 - 5.8e-14 51.9 12.1 1.2e-13 51.0 12.1 1.5 1 0 0 1 1 1 1 bZIP transcription factor Apc13p PF05839.11 EDO16020.1 - 9.9e-09 35.3 0.0 3.2e-08 33.7 0.0 1.9 2 1 0 2 2 2 1 Apc13p protein PalH PF08733.10 EDO16021.1 - 5e-82 275.6 20.1 7e-82 275.1 20.1 1.2 1 0 0 1 1 1 1 PalH/RIM21 LAMTOR PF15454.6 EDO16021.1 - 0.051 14.2 1.0 0.24 12.1 0.3 2.5 2 0 0 2 2 2 0 Late endosomal/lysosomal adaptor and MAPK and MTOR activator Gemini_AC4_5 PF04807.12 EDO16021.1 - 0.13 12.0 0.2 0.25 11.1 0.2 1.5 1 0 0 1 1 1 0 Geminivirus AC4/5 conserved region zf-C2H2 PF00096.26 EDO16022.1 - 1.7e-11 43.9 5.4 3.1e-05 24.2 0.4 3.0 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EDO16022.1 - 1.8e-07 31.4 5.0 0.012 16.4 0.3 3.0 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EDO16022.1 - 1e-06 28.9 11.5 0.00031 21.0 0.5 3.7 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_11 PF16622.5 EDO16022.1 - 0.029 14.1 1.6 3.6 7.4 0.5 2.5 2 0 0 2 2 2 0 zinc-finger C2H2-type DUF1882 PF08966.11 EDO16022.1 - 0.079 13.2 0.2 0.25 11.6 0.2 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF1882) MCM_OB PF17207.3 EDO16022.1 - 0.12 12.2 1.2 0.26 11.1 1.2 1.4 1 0 0 1 1 1 0 MCM OB domain zf-C2H2_8 PF15909.5 EDO16022.1 - 0.25 11.7 2.1 0.78 10.1 2.1 1.8 1 0 0 1 1 1 0 C2H2-type zinc ribbon zf-met PF12874.7 EDO16022.1 - 0.36 11.3 3.8 0.75 10.3 0.4 2.9 2 0 0 2 2 2 0 Zinc-finger of C2H2 type C1_2 PF03107.16 EDO16022.1 - 3.8 7.9 5.4 5.5 7.4 0.4 2.4 1 1 1 2 2 2 0 C1 domain Ogr_Delta PF04606.12 EDO16022.1 - 4.8 7.2 5.3 5.1 7.2 1.6 2.7 2 1 1 3 3 3 0 Ogr/Delta-like zinc finger Fungal_trans PF04082.18 EDO16023.1 - 1.2e-18 67.1 2.5 1.2e-18 67.1 2.5 2.1 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDO16023.1 - 2.6e-09 37.0 12.7 6.4e-09 35.8 12.7 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Chordopox_A30L PF06015.12 EDO16024.1 - 0.12 12.2 13.1 1.6 8.6 2.0 4.1 3 0 0 3 3 3 0 Chordopoxvirus A30L protein PQ-loop PF04193.14 EDO16025.1 - 1.9e-40 136.4 17.9 3.8e-23 81.0 1.1 3.0 3 0 0 3 3 3 2 PQ loop repeat Bac_export_2 PF01312.19 EDO16025.1 - 0.063 12.5 0.2 0.063 12.5 0.2 1.8 2 0 0 2 2 2 0 FlhB HrpN YscU SpaS Family Steroid_dh PF02544.16 EDO16025.1 - 0.27 11.2 3.9 0.38 10.7 1.6 2.4 2 1 0 2 2 2 0 3-oxo-5-alpha-steroid 4-dehydrogenase Snf7 PF03357.21 EDO16026.1 - 4.6e-38 130.5 20.5 5.8e-38 130.2 20.5 1.1 1 0 0 1 1 1 1 Snf7 Fmp27_WPPW PF10359.9 EDO16026.1 - 0.00036 19.5 7.7 0.00044 19.2 7.7 1.2 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain Tropomyosin_1 PF12718.7 EDO16026.1 - 0.0094 16.1 9.5 0.019 15.2 9.3 1.6 1 1 0 1 1 1 1 Tropomyosin like GP63 PF17471.2 EDO16026.1 - 0.076 13.2 0.3 7.2 6.8 0.0 2.3 1 1 0 2 2 2 0 Gene product 63 YlqD PF11068.8 EDO16026.1 - 0.093 13.1 20.6 1.5 9.2 20.6 2.2 1 1 0 1 1 1 0 YlqD protein Not3 PF04065.15 EDO16026.1 - 0.15 11.4 13.3 0.46 9.9 13.2 1.8 1 1 1 2 2 2 0 Not1 N-terminal domain, CCR4-Not complex component Methyltrn_RNA_4 PF09936.9 EDO16026.1 - 0.16 11.9 0.6 0.24 11.2 0.6 1.3 1 0 0 1 1 1 0 SAM-dependent RNA methyltransferase FliJ PF02050.16 EDO16026.1 - 0.16 12.2 17.5 0.031 14.5 11.1 2.4 1 1 1 2 2 2 0 Flagellar FliJ protein Serine_rich PF08824.10 EDO16026.1 - 0.27 11.2 9.4 0.6 10.1 8.5 2.0 1 1 0 1 1 1 0 Serine rich protein interaction domain SKA1 PF07160.12 EDO16026.1 - 0.31 10.9 13.4 0.28 11.0 11.6 1.7 1 1 1 2 2 2 0 Spindle and kinetochore-associated protein 1 Cep57_MT_bd PF06657.13 EDO16026.1 - 0.7 10.4 8.4 0.23 11.9 2.2 2.8 1 1 2 3 3 3 0 Centrosome microtubule-binding domain of Cep57 Swi5 PF07061.11 EDO16026.1 - 0.84 9.8 10.3 5.3e+02 0.8 10.0 3.0 1 1 0 1 1 1 0 Swi5 Peptidase_S46 PF10459.9 EDO16026.1 - 0.94 8.0 9.7 1.1 7.8 9.7 1.0 1 0 0 1 1 1 0 Peptidase S46 Fib_alpha PF08702.10 EDO16026.1 - 1.2 9.3 18.2 4 7.6 7.8 2.1 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family GrpE PF01025.19 EDO16026.1 - 1.6 8.4 11.2 0.85 9.3 8.1 1.9 1 1 1 2 2 2 0 GrpE Ntox28 PF15605.6 EDO16026.1 - 1.8 8.8 8.3 2.3 8.5 0.3 2.8 1 1 0 2 2 2 0 Bacterial toxin 28 ACR_tran PF00873.19 EDO16026.1 - 1.9 6.1 9.1 2.4 5.7 9.1 1.1 1 0 0 1 1 1 0 AcrB/AcrD/AcrF family Cep57_CLD_2 PF14197.6 EDO16026.1 - 2 8.6 12.1 9.3 6.4 3.2 3.5 3 1 0 3 3 3 0 Centrosome localisation domain of PPC89 Jnk-SapK_ap_N PF09744.9 EDO16026.1 - 2 8.6 15.2 4.6 7.4 8.6 2.3 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 FlaC_arch PF05377.11 EDO16026.1 - 2.3 8.6 7.1 10 6.6 0.1 3.6 2 1 0 3 3 3 0 Flagella accessory protein C (FlaC) Exonuc_VII_L PF02601.15 EDO16026.1 - 3.1 7.3 13.5 4.5 6.8 13.5 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit IZUMO PF15005.6 EDO16026.1 - 3.4 8.2 7.7 7.6 7.0 6.9 1.9 1 1 1 2 2 2 0 Izumo sperm-egg fusion, Ig domain-associated tRNA-synt_1b PF00579.25 EDO16027.1 - 1.8e-17 63.6 0.0 1.9e-11 43.9 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class I (W and Y) DHBP_synthase PF00926.19 EDO16028.1 - 6.7e-82 273.7 0.0 7.6e-82 273.5 0.0 1.0 1 0 0 1 1 1 1 3,4-dihydroxy-2-butanone 4-phosphate synthase Erv26 PF04148.13 EDO16029.1 - 9.5e-85 283.6 4.3 1.1e-84 283.4 4.3 1.0 1 0 0 1 1 1 1 Transmembrane adaptor Erv26 DUF996 PF06195.13 EDO16029.1 - 0.012 15.9 2.2 0.012 15.9 2.2 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF996) Cytochrom_C_asm PF01578.20 EDO16029.1 - 0.64 9.8 6.2 0.24 11.2 1.7 2.4 1 1 1 3 3 3 0 Cytochrome C assembly protein NAD_binding_2 PF03446.15 EDO16030.1 - 3.8e-52 176.6 0.0 4.5e-52 176.4 0.0 1.1 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase 6PGD PF00393.19 EDO16030.1 - 3.8e-15 56.0 0.9 5.3e-15 55.6 0.9 1.2 1 0 0 1 1 1 1 6-phosphogluconate dehydrogenase, C-terminal domain F420_oxidored PF03807.17 EDO16030.1 - 0.0019 18.8 0.0 0.0033 18.0 0.0 1.4 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_11 PF14833.6 EDO16030.1 - 0.063 13.5 0.0 0.11 12.8 0.0 1.3 1 0 0 1 1 1 0 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase Ub-Mut7C PF14451.6 EDO16030.1 - 0.1 12.5 0.0 0.27 11.1 0.0 1.7 1 1 1 2 2 2 0 Mut7-C ubiquitin 6PGD PF00393.19 EDO16031.1 - 1.2e-100 336.7 0.0 1.3e-100 336.5 0.0 1.0 1 0 0 1 1 1 1 6-phosphogluconate dehydrogenase, C-terminal domain Mito_carr PF00153.27 EDO16032.1 - 8.6e-64 211.5 0.2 3.4e-22 78.2 0.0 3.5 3 1 0 3 3 3 3 Mitochondrial carrier protein CCDC84 PF14968.6 EDO16032.1 - 0.13 11.8 0.3 0.21 11.2 0.3 1.2 1 0 0 1 1 1 0 Coiled coil protein 84 Macoilin PF09726.9 EDO16033.1 - 0.023 13.3 3.2 0.028 13.0 3.2 1.1 1 0 0 1 1 1 0 Macoilin family Tim54 PF11711.8 EDO16033.1 - 0.086 11.6 2.1 0.13 11.1 2.1 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Zip PF02535.22 EDO16033.1 - 1.5 8.0 2.5 2 7.5 2.5 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter DUF4834 PF16118.5 EDO16033.1 - 3.9 8.5 6.4 9.3 7.3 6.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Menin PF05053.13 EDO16033.1 - 8.4 4.6 12.5 12 4.1 12.5 1.1 1 0 0 1 1 1 0 Menin MFS_1 PF07690.16 EDO16034.1 - 2e-33 115.8 24.1 2.8e-33 115.3 24.1 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Gpi16 PF04113.14 EDO16035.1 - 9.3e-178 592.2 0.0 1.2e-177 591.8 0.0 1.0 1 0 0 1 1 1 1 Gpi16 subunit, GPI transamidase component LRR_adjacent PF08191.11 EDO16035.1 - 0.2 11.9 0.6 0.57 10.4 0.0 2.0 2 0 0 2 2 2 0 LRR adjacent HEAT PF02985.22 EDO16036.1 - 1.8e-15 55.7 8.4 0.11 12.8 0.0 9.1 11 0 0 11 11 8 4 HEAT repeat HEAT_EZ PF13513.6 EDO16036.1 - 3.2e-15 56.3 0.0 0.29 11.7 0.0 7.8 7 0 0 7 7 7 4 HEAT-like repeat HEAT_2 PF13646.6 EDO16036.1 - 7.1e-12 45.6 0.1 0.1 13.0 0.0 7.1 4 2 2 8 8 8 2 HEAT repeats Vac14_Fab1_bd PF12755.7 EDO16036.1 - 1e-07 32.5 0.4 0.051 14.2 0.0 6.0 4 2 3 7 7 7 1 Vacuolar 14 Fab1-binding region Adaptin_N PF01602.20 EDO16036.1 - 1.4e-07 30.5 7.4 0.0063 15.1 1.5 3.7 3 1 0 3 3 3 2 Adaptin N terminal region DUF3385 PF11865.8 EDO16036.1 - 2.7e-07 30.6 5.6 0.68 9.8 0.2 6.2 4 3 1 5 5 5 3 Domain of unknown function (DUF3385) Cnd1 PF12717.7 EDO16036.1 - 2.4e-06 27.7 8.8 2.1 8.4 0.4 5.5 4 2 1 5 5 5 3 non-SMC mitotic condensation complex subunit 1 CLASP_N PF12348.8 EDO16036.1 - 0.00026 20.6 2.2 2.2 7.8 0.1 5.6 4 2 3 7 7 7 1 CLASP N terminal Arm PF00514.23 EDO16036.1 - 0.00055 19.9 1.9 24 5.1 0.0 5.9 6 0 0 6 6 6 0 Armadillo/beta-catenin-like repeat NUC173 PF08161.12 EDO16036.1 - 0.026 14.2 0.2 0.74 9.4 0.0 3.5 3 0 0 3 3 3 0 NUC173 domain Proteasom_PSMB PF10508.9 EDO16036.1 - 0.043 12.3 0.4 0.71 8.3 0.3 3.0 2 1 1 3 3 3 0 Proteasome non-ATPase 26S subunit MMS19_C PF12460.8 EDO16036.1 - 0.078 12.1 6.3 6 5.9 0.0 4.9 3 2 1 4 4 4 0 RNAPII transcription regulator C-terminal Adaptin_N PF01602.20 EDO16037.1 - 9.3e-84 281.8 7.9 1.1e-83 281.6 7.9 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 EDO16037.1 - 1.2e-13 51.4 8.4 6.2e-13 49.1 0.1 3.2 4 0 0 4 4 4 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EDO16037.1 - 1.6e-09 38.1 0.0 2.2e-06 28.0 0.0 4.0 2 2 1 4 4 4 1 HEAT repeats HEAT PF02985.22 EDO16037.1 - 1.4e-05 24.9 1.0 2.1 8.8 0.0 5.3 5 0 0 5 5 5 2 HEAT repeat HEAT_EZ PF13513.6 EDO16037.1 - 0.048 14.2 0.1 9.8 6.8 0.0 3.5 3 1 1 4 4 4 0 HEAT-like repeat Vac14_Fab1_bd PF12755.7 EDO16037.1 - 0.074 13.6 0.8 3.1 8.4 0.0 3.1 2 1 1 3 3 2 0 Vacuolar 14 Fab1-binding region Cohesin_HEAT PF12765.7 EDO16037.1 - 0.11 12.9 1.3 0.66 10.3 0.0 2.9 3 0 0 3 3 2 0 HEAT repeat associated with sister chromatid cohesion Prp18 PF02840.15 EDO16037.1 - 0.12 12.4 0.7 0.54 10.3 0.2 2.2 2 0 0 2 2 2 0 Prp18 domain Na_Ca_ex_C PF16494.5 EDO16037.1 - 0.21 12.0 1.2 0.95 9.9 0.1 2.3 2 0 0 2 2 2 0 C-terminal extension of sodium/calcium exchanger domain UNC45-central PF11701.8 EDO16037.1 - 0.22 11.5 3.7 2.9 7.8 0.0 3.2 3 0 0 3 3 3 0 Myosin-binding striated muscle assembly central EIF_2_alpha PF07541.12 EDO16037.1 - 1.1 9.4 3.5 7.9 6.6 0.0 3.3 2 2 1 3 3 3 0 Eukaryotic translation initiation factor 2 alpha subunit RIH_assoc PF08454.11 EDO16037.1 - 1.9 8.4 5.7 0.75 9.7 2.3 2.2 2 0 0 2 2 2 0 RyR and IP3R Homology associated Aminotran_4 PF01063.19 EDO16038.1 - 3.8e-22 79.3 0.0 2e-21 76.9 0.0 1.8 1 1 0 1 1 1 1 Amino-transferase class IV GxGYxYP_C PF14323.6 EDO16038.1 - 0.0096 15.8 0.0 0.031 14.2 0.0 1.7 2 0 0 2 2 2 1 GxGYxYP putative glycoside hydrolase C-terminal domain Kdo PF06293.14 EDO16039.1 - 1e-05 25.0 0.0 2.5e-05 23.8 0.0 1.5 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EDO16039.1 - 0.011 15.6 0.1 0.18 11.7 0.1 2.0 2 0 0 2 2 2 0 Phosphotransferase enzyme family DUF1679 PF07914.11 EDO16039.1 - 0.02 13.8 0.0 0.041 12.8 0.0 1.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1679) Pkinase PF00069.25 EDO16039.1 - 0.027 13.9 0.0 0.041 13.2 0.0 1.3 1 0 0 1 1 1 0 Protein kinase domain FMO-like PF00743.19 EDO16039.1 - 0.11 10.9 0.0 0.29 9.5 0.0 1.6 2 0 0 2 2 2 0 Flavin-binding monooxygenase-like Say1_Mug180 PF10340.9 EDO16040.1 - 6.9e-170 564.9 6.1 7.8e-170 564.7 6.1 1.0 1 0 0 1 1 1 1 Steryl acetyl hydrolase Abhydrolase_3 PF07859.13 EDO16040.1 - 2.2e-13 50.6 0.0 6.8e-13 49.0 0.0 1.8 2 1 0 2 2 2 1 alpha/beta hydrolase fold COesterase PF00135.28 EDO16040.1 - 0.0086 15.0 0.0 1.9 7.3 0.0 2.1 2 0 0 2 2 2 2 Carboxylesterase family Hydrolase_4 PF12146.8 EDO16040.1 - 0.098 11.9 0.0 0.15 11.3 0.0 1.2 1 0 0 1 1 1 0 Serine aminopeptidase, S33 tRNA-synt_1g PF09334.11 EDO16041.1 - 1.3e-156 521.3 0.6 1.7e-156 520.9 0.6 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (M) MetRS-N PF09635.10 EDO16041.1 - 1.3e-23 83.8 0.6 3.2e-23 82.6 0.1 1.9 2 0 0 2 2 2 1 MetRS-N binding domain tRNA-synt_1 PF00133.22 EDO16041.1 - 2.6e-10 39.2 1.8 0.00052 18.4 0.0 2.9 1 1 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1e PF01406.19 EDO16041.1 - 0.049 13.0 0.0 0.26 10.6 0.0 2.1 3 0 0 3 3 3 0 tRNA synthetases class I (C) catalytic domain Anticodon_1 PF08264.13 EDO16041.1 - 0.073 13.0 0.5 0.37 10.7 0.0 2.4 3 0 0 3 3 3 0 Anticodon-binding domain of tRNA Pkinase PF00069.25 EDO16042.1 - 6.4e-45 153.6 0.5 4.3e-36 124.6 0.1 2.5 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EDO16042.1 - 6.1e-22 78.1 0.1 5.7e-19 68.4 0.0 2.9 3 0 0 3 3 3 2 Protein tyrosine kinase Pkinase_fungal PF17667.1 EDO16042.1 - 0.00075 18.4 0.2 0.0014 17.5 0.2 1.3 1 0 0 1 1 1 1 Fungal protein kinase GTP_cyclohydroI PF01227.22 EDO16043.1 - 1.5e-74 249.3 0.2 1.8e-74 249.1 0.2 1.1 1 0 0 1 1 1 1 GTP cyclohydrolase I QueF PF14489.6 EDO16043.1 - 0.00017 21.6 0.0 0.00043 20.4 0.0 1.7 1 0 0 1 1 1 1 QueF-like protein Got1 PF04178.12 EDO16044.1 - 6.9e-13 49.0 9.6 7.9e-13 48.8 9.6 1.1 1 0 0 1 1 1 1 Got1/Sft2-like family ATP1G1_PLM_MAT8 PF02038.16 EDO16044.1 - 0.5 9.8 6.9 4.7 6.7 0.9 2.5 2 0 0 2 2 2 0 ATP1G1/PLM/MAT8 family YtpI PF14007.6 EDO16044.1 - 6.8 6.9 14.4 13 6.0 0.4 2.5 1 1 2 3 3 3 0 YtpI-like protein Amidase PF01425.21 EDO16045.1 - 9.6e-125 417.1 0.0 1.2e-124 416.8 0.0 1.0 1 0 0 1 1 1 1 Amidase MDM31_MDM32 PF08118.11 EDO16046.1 - 2.2e-213 709.7 6.4 2.5e-213 709.5 6.4 1.0 1 0 0 1 1 1 1 Yeast mitochondrial distribution and morphology (MDM) proteins Nbs1_C PF08599.10 EDO16047.1 - 0.057 13.6 1.3 0.057 13.6 1.3 2.2 2 0 0 2 2 2 0 DNA damage repair protein Nbs1 RNA_pol_A_bac PF01000.26 EDO16047.1 - 0.15 12.4 2.7 0.36 11.2 1.3 2.4 3 1 0 3 3 3 0 RNA polymerase Rpb3/RpoA insert domain LIN37 PF15306.6 EDO16047.1 - 0.43 10.8 10.7 0.83 9.9 10.7 1.4 1 0 0 1 1 1 0 LIN37 Presenilin PF01080.17 EDO16047.1 - 1.1 8.0 11.5 1.9 7.2 11.5 1.3 1 0 0 1 1 1 0 Presenilin Chorein_N PF12624.7 EDO16047.1 - 1.1 9.4 10.4 0.82 9.8 3.4 2.5 2 0 0 2 2 2 0 N-terminal region of Chorein or VPS13 IBN_N PF03810.19 EDO16048.1 - 4.8e-19 68.0 0.0 1.2e-16 60.4 0.0 3.6 3 0 0 3 3 3 2 Importin-beta N-terminal domain Utp12 PF04003.12 EDO16049.1 - 3e-07 30.7 0.5 5.1e-07 30.0 0.5 1.4 1 0 0 1 1 1 1 Dip2/Utp12 Family TMF_TATA_bd PF12325.8 EDO16050.1 - 7.8e-31 106.7 21.1 7.8e-31 106.7 21.1 5.9 2 1 4 6 6 6 1 TATA element modulatory factor 1 TATA binding TMF_DNA_bd PF12329.8 EDO16050.1 - 1.1e-16 60.6 8.5 1.1e-16 60.6 8.5 9.4 5 3 5 10 10 10 2 TATA element modulatory factor 1 DNA binding Lebercilin PF15619.6 EDO16050.1 - 0.026 14.2 82.4 0.065 12.9 15.0 4.7 2 1 1 4 4 4 0 Ciliary protein causing Leber congenital amaurosis disease ATG16 PF08614.11 EDO16050.1 - 3.4 7.8 75.8 0.25 11.6 17.2 4.5 3 1 1 4 4 4 0 Autophagy protein 16 (ATG16) Mito_carr PF00153.27 EDO16051.1 - 1.7e-15 56.7 0.7 9.6e-13 47.9 0.1 2.8 3 0 0 3 3 3 2 Mitochondrial carrier protein Pro_isomerase PF00160.21 EDO16052.1 - 3e-41 141.3 0.0 4.6e-41 140.7 0.0 1.3 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TPR_2 PF07719.17 EDO16052.1 - 3.6e-10 39.2 9.3 1.1e-05 25.2 2.2 3.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.28 EDO16052.1 - 1.3e-09 37.4 15.3 1.3e-07 31.1 3.4 3.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 EDO16052.1 - 5.3e-07 29.3 9.6 0.0013 18.7 0.8 3.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 EDO16052.1 - 7.3e-05 23.0 1.4 0.12 12.7 0.5 3.1 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.6 EDO16052.1 - 7.7e-05 22.3 8.2 0.0062 16.2 0.5 3.5 3 1 1 4 4 4 3 TPR repeat TPR_16 PF13432.6 EDO16052.1 - 0.0014 19.2 0.2 0.073 13.7 0.1 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.6 EDO16052.1 - 0.0055 17.3 2.0 0.51 11.1 0.3 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_10 PF13374.6 EDO16052.1 - 0.37 10.7 2.3 1.7 8.6 0.6 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat MIT PF04212.18 EDO16052.1 - 1.2 9.3 4.4 1.3 9.2 0.1 2.5 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain Rav1p_C PF12234.8 EDO16053.1 - 1.3e-255 849.7 3.0 4.3e-255 848.1 0.4 2.1 2 0 0 2 2 2 2 RAVE protein 1 C terminal Pet191_N PF10203.9 EDO16054.1 - 1.5e-24 86.1 4.3 2.2e-24 85.5 4.3 1.3 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein PET191 CHCH PF06747.13 EDO16054.1 - 0.12 12.5 4.8 0.26 11.5 0.4 2.7 3 0 0 3 3 3 0 CHCH domain CX9C PF16860.5 EDO16054.1 - 0.16 12.0 6.1 0.98 9.5 0.5 3.1 2 1 1 3 3 3 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, SNF2_N PF00176.23 EDO16055.1 - 4.7e-73 245.9 0.1 8.6e-73 245.1 0.1 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EDO16055.1 - 1.3e-21 77.0 0.0 8.3e-21 74.4 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDO16055.1 - 0.00017 21.6 0.0 0.00017 21.6 0.0 4.0 3 2 0 3 3 3 1 Type III restriction enzyme, res subunit DUF4164 PF13747.6 EDO16055.1 - 0.31 11.4 8.1 1 9.7 8.1 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4164) DUF2235 PF09994.9 EDO16056.1 - 8.2e-78 261.7 0.0 1.6e-77 260.7 0.0 1.5 1 0 0 1 1 1 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) HECT PF00632.25 EDO16057.1 - 1.4e-83 280.9 2.5 4.2e-83 279.4 1.4 2.1 2 0 0 2 2 2 1 HECT-domain (ubiquitin-transferase) Lig_C PF18330.1 EDO16057.1 - 0.029 14.4 2.6 0.93 9.5 0.1 2.8 3 0 0 3 3 3 0 Ligase Pab1020 C-terminal region Holin_BhlA PF10960.8 EDO16057.1 - 0.064 13.2 0.1 0.19 11.7 0.1 1.8 1 0 0 1 1 1 0 BhlA holin family Ribosomal_L7Ae PF01248.26 EDO16058.1 - 1e-26 92.4 0.1 1.3e-26 92.2 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family PELOTA_1 PF15608.6 EDO16058.1 - 0.0043 16.9 0.0 0.0059 16.5 0.0 1.3 1 0 0 1 1 1 1 PELOTA RNA binding domain RNase_P_pop3 PF08228.11 EDO16058.1 - 0.015 15.4 0.0 0.017 15.2 0.0 1.1 1 0 0 1 1 1 0 RNase P subunit Pop3 Voltage_CLC PF00654.20 EDO16059.1 - 2.8e-77 260.4 25.9 2.8e-77 260.4 25.9 1.5 2 0 0 2 2 2 1 Voltage gated chloride channel CBS PF00571.28 EDO16059.1 - 1.2e-11 44.8 0.0 3.4e-05 24.2 0.0 2.7 2 0 0 2 2 2 2 CBS domain ATP-synt_C PF00137.21 EDO16060.1 - 5.5e-35 119.5 31.9 2.3e-22 79.1 13.6 2.1 2 0 0 2 2 2 2 ATP synthase subunit C CDC27 PF09507.10 EDO16061.1 - 9.6e-08 31.8 35.4 9.6e-08 31.8 35.4 1.5 2 0 0 2 2 2 1 DNA polymerase subunit Cdc27 DUF4407 PF14362.6 EDO16061.1 - 0.23 10.8 13.8 0.33 10.3 13.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) UCH PF00443.29 EDO16062.1 - 2.4e-48 164.9 1.7 2.4e-48 164.9 1.7 3.3 3 1 0 3 3 3 1 Ubiquitin carboxyl-terminal hydrolase RPT PF13446.6 EDO16062.1 - 7.2e-25 86.7 16.4 1.1e-12 47.7 0.4 4.6 6 0 0 6 6 6 3 A repeated domain in UCH-protein UCH_1 PF13423.6 EDO16062.1 - 0.0061 16.2 1.0 0.0061 16.2 1.0 3.8 3 1 0 3 3 3 2 Ubiquitin carboxyl-terminal hydrolase Sec23_helical PF04815.15 EDO16062.1 - 0.15 11.9 0.8 1.1 9.1 0.1 2.7 2 0 0 2 2 2 0 Sec23/Sec24 helical domain GPP34 PF05719.11 EDO16063.1 - 8.9e-65 218.5 0.0 1e-64 218.3 0.0 1.1 1 0 0 1 1 1 1 Golgi phosphoprotein 3 (GPP34) YCII PF03795.14 EDO16064.1 - 1.7e-08 34.7 0.0 2e-08 34.5 0.0 1.0 1 0 0 1 1 1 1 YCII-related domain YCII PF03795.14 EDO16065.1 - 1.8e-06 28.3 0.0 2.2e-06 28.0 0.0 1.1 1 0 0 1 1 1 1 YCII-related domain FHA PF00498.26 EDO16066.1 - 0.00016 22.0 0.6 0.00053 20.3 0.1 2.2 2 0 0 2 2 2 1 FHA domain FHA_2 PF17913.1 EDO16066.1 - 0.00043 20.5 0.2 0.00043 20.5 0.2 2.7 3 0 0 3 3 3 1 FHA domain TLD PF07534.16 EDO16067.1 - 1.8e-27 96.2 0.1 1.9e-26 92.9 0.1 2.2 2 0 0 2 2 2 1 TLD NUC153 PF08159.12 EDO16068.1 - 2.4e-13 49.6 3.8 2.4e-13 49.6 3.8 2.9 3 0 0 3 3 3 2 NUC153 domain RNA_pol_Rpb1_5 PF04998.17 EDO16069.1 - 1.9e-83 280.0 0.2 2.7e-83 279.5 0.2 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_1 PF04997.12 EDO16069.1 - 1.6e-81 274.1 0.0 4.8e-81 272.5 0.0 1.8 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_2 PF00623.20 EDO16069.1 - 6.1e-76 254.3 0.1 1.5e-75 252.9 0.0 1.8 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.18 EDO16069.1 - 3.2e-39 134.4 0.0 8.7e-39 133.0 0.0 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.17 EDO16069.1 - 7.3e-31 106.3 0.0 2.4e-30 104.7 0.0 2.0 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 Peptidase_M18 PF02127.15 EDO16070.1 - 2.2e-181 603.4 0.0 2.4e-181 603.2 0.0 1.0 1 0 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) Peptidase_M42 PF05343.14 EDO16070.1 - 7.9e-08 31.7 0.0 0.00013 21.1 0.0 2.2 2 0 0 2 2 2 2 M42 glutamyl aminopeptidase WD40 PF00400.32 EDO16071.1 - 1.5e-26 92.1 11.2 1.6e-05 25.6 0.1 6.3 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDO16071.1 - 3.6e-08 33.6 0.1 0.072 13.4 0.0 4.5 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain EMP24_GP25L PF01105.24 EDO16071.1 - 0.016 15.2 0.7 0.038 13.9 0.7 1.7 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD Ge1_WD40 PF16529.5 EDO16071.1 - 1.1 8.1 6.5 0.19 10.6 1.3 2.5 3 2 1 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein GATA PF00320.27 EDO16072.1 - 9.8e-15 53.9 3.0 1.8e-14 53.0 3.0 1.5 1 0 0 1 1 1 1 GATA zinc finger TF_Zn_Ribbon PF08271.12 EDO16072.1 - 0.0071 15.8 0.3 0.016 14.7 0.3 1.6 1 0 0 1 1 1 1 TFIIB zinc-binding PHD PF00628.29 EDO16073.1 - 4e-10 39.4 9.2 9.3e-10 38.2 9.2 1.7 1 0 0 1 1 1 1 PHD-finger SET PF00856.28 EDO16073.1 - 6.2e-06 26.7 0.4 6.2e-06 26.7 0.4 2.6 1 1 1 2 2 2 1 SET domain PHD_2 PF13831.6 EDO16073.1 - 0.0047 16.4 4.2 0.01 15.4 4.2 1.5 1 0 0 1 1 1 1 PHD-finger zf-CW PF07496.15 EDO16073.1 - 0.77 9.8 6.2 0.35 10.9 3.1 2.2 2 0 0 2 2 2 0 CW-type Zinc Finger DEAD PF00270.29 EDO16074.1 - 3.7e-40 137.6 0.1 6.8e-40 136.7 0.1 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDO16074.1 - 1.3e-18 67.4 0.0 6.5e-18 65.1 0.0 2.1 1 1 0 2 2 2 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 EDO16074.1 - 2.2e-17 63.0 0.1 5e-17 61.9 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 EDO16074.1 - 3.9e-06 27.0 0.0 1.2e-05 25.4 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Gal11_ABD1 PF18535.1 EDO16074.1 - 0.0088 16.1 0.8 0.019 15.0 0.1 1.9 2 0 0 2 2 2 1 Gal11 activator-binding domain (ABD1) AAA_22 PF13401.6 EDO16074.1 - 0.11 12.8 1.8 1 9.6 0.6 2.9 2 1 0 2 2 2 0 AAA domain IF-2B PF01008.17 EDO16075.1 - 3.2e-71 239.8 0.0 3.7e-71 239.6 0.0 1.0 1 0 0 1 1 1 1 Initiation factor 2 subunit family DeoRC PF00455.22 EDO16075.1 - 0.038 13.9 0.0 10 6.0 0.0 2.4 2 0 0 2 2 2 0 DeoR C terminal sensor domain PTPLA PF04387.14 EDO16076.1 - 1.1e-51 174.9 6.3 1.1e-51 174.9 6.3 1.4 2 0 0 2 2 2 1 Protein tyrosine phosphatase-like protein, PTPLA BRCT PF00533.26 EDO16077.1 - 2.9e-17 62.8 13.5 2.7e-07 30.9 0.1 5.1 4 1 0 4 4 4 3 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 EDO16077.1 - 8.9e-12 45.3 4.7 0.0007 20.0 0.0 3.8 3 0 0 3 3 3 3 BRCT domain, a BRCA1 C-terminus domain PTCB-BRCT PF12738.7 EDO16077.1 - 1.4e-10 41.0 0.5 4.8e-06 26.4 0.0 4.3 4 1 0 4 4 4 3 twin BRCT domain Zn_clus PF00172.18 EDO16078.1 - 1.2e-10 41.3 10.3 2.3e-10 40.4 10.3 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain OTCace PF00185.24 EDO16079.1 - 5.2e-49 166.3 0.8 7.6e-49 165.8 0.8 1.2 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain OTCace_N PF02729.21 EDO16079.1 - 8.5e-42 142.7 0.0 1.3e-41 142.1 0.0 1.3 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain BTB PF00651.31 EDO16079.1 - 0.078 13.2 0.1 0.53 10.5 0.0 2.2 2 0 0 2 2 2 0 BTB/POZ domain Vps51 PF08700.11 EDO16080.1 - 1.9e-11 43.9 2.8 1.9e-11 43.9 2.8 1.8 2 0 0 2 2 2 1 Vps51/Vps67 Hrs_helical PF12210.8 EDO16080.1 - 0.071 13.7 0.6 0.071 13.7 0.6 2.2 2 1 0 2 2 2 0 Hepatocyte growth factor-regulated tyrosine kinase substrate EF-hand_4 PF12763.7 EDO16081.1 - 0.00021 21.2 0.2 0.00097 19.1 0.2 2.3 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand Ras PF00071.22 EDO16082.1 - 1.8e-56 190.2 0.4 2.1e-56 190.0 0.4 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EDO16082.1 - 3.1e-36 124.2 0.1 4.7e-36 123.6 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EDO16082.1 - 9.9e-15 54.4 0.1 1.3e-14 54.0 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EDO16082.1 - 1.8e-06 27.5 0.2 2.2e-06 27.2 0.2 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EDO16082.1 - 1.8e-05 24.8 0.0 3.5e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EDO16082.1 - 2.6e-05 24.2 0.1 0.099 12.5 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 EDO16082.1 - 4e-05 23.2 0.0 6.8e-05 22.5 0.0 1.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_16 PF13191.6 EDO16082.1 - 0.0076 16.7 0.0 0.013 15.9 0.0 1.4 1 1 0 1 1 1 1 AAA ATPase domain TniB PF05621.11 EDO16082.1 - 0.023 14.1 0.0 0.044 13.2 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein G-alpha PF00503.20 EDO16082.1 - 0.061 12.5 0.8 1.8 7.6 0.0 2.6 1 1 1 2 2 2 0 G-protein alpha subunit Septin PF00735.18 EDO16082.1 - 0.087 12.1 0.0 0.17 11.1 0.0 1.5 1 0 0 1 1 1 0 Septin KH_1 PF00013.29 EDO16083.1 - 9e-68 224.0 37.1 2e-15 56.3 2.1 12.1 12 0 0 12 12 12 10 KH domain KH_2 PF07650.17 EDO16083.1 - 2.2e-09 37.0 14.8 1.4e-05 24.8 0.4 7.0 7 0 0 7 7 7 3 KH domain KH_4 PF13083.6 EDO16083.1 - 0.00037 20.3 0.9 0.72 9.8 0.0 5.2 4 0 0 4 4 4 1 KH domain DUF4056 PF13265.6 EDO16083.1 - 0.15 11.3 0.2 0.32 10.3 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4056) CAP PF00188.26 EDO16084.1 - 4.2e-18 66.4 5.7 4.2e-18 66.4 5.7 1.9 2 0 0 2 2 2 1 Cysteine-rich secretory protein family Hamartin PF04388.12 EDO16084.1 - 0.58 8.8 5.6 0.64 8.6 5.6 1.0 1 0 0 1 1 1 0 Hamartin protein TFIIA PF03153.13 EDO16084.1 - 5 7.0 11.1 6.3 6.7 11.1 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Cytokin_check_N PF10407.9 EDO16086.1 - 2e-28 98.1 5.7 2e-28 98.1 5.7 3.0 3 0 0 3 3 3 1 Cdc14 phosphatase binding protein N-terminus SOGA PF11365.8 EDO16087.1 - 1.8 9.7 11.3 0.17 13.1 0.7 2.5 3 0 0 3 3 3 0 Protein SOGA zf-H2C2_2 PF13465.6 EDO16089.1 - 8.1e-06 26.0 8.7 7e-05 23.1 4.4 2.7 2 0 0 2 2 2 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 EDO16089.1 - 0.0029 18.3 13.3 0.12 13.3 3.4 2.9 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.26 EDO16089.1 - 0.0045 17.4 13.3 0.091 13.3 4.2 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type DUF3343 PF11823.8 EDO16089.1 - 0.19 11.2 0.1 0.83 9.2 0.1 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3343) ENTH PF01417.20 EDO16090.1 - 1.4e-45 154.4 0.4 1.4e-45 154.4 0.4 2.1 3 0 0 3 3 3 1 ENTH domain ANTH PF07651.16 EDO16090.1 - 0.00055 19.0 0.0 0.00086 18.4 0.0 1.3 1 0 0 1 1 1 1 ANTH domain VHS PF00790.19 EDO16090.1 - 0.031 14.1 0.1 0.057 13.3 0.1 1.4 1 0 0 1 1 1 0 VHS domain Zn_clus PF00172.18 EDO16091.1 - 0.005 16.9 8.1 0.011 15.9 8.1 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain HMG-CoA_red PF00368.18 EDO16092.1 - 3.6e-140 467.2 0.8 5.1e-140 466.6 0.8 1.2 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A reductase HPIH PF13323.6 EDO16092.1 - 8.2e-45 152.5 1.8 2.2e-44 151.1 1.8 1.8 1 0 0 1 1 1 1 N-terminal domain with HPIH motif Sterol-sensing PF12349.8 EDO16092.1 - 2.6e-07 30.6 10.2 2.7e-07 30.6 7.6 2.3 2 0 0 2 2 2 1 Sterol-sensing domain of SREBP cleavage-activation Ribosomal_L6e PF01159.19 EDO16093.1 - 2.5e-37 127.8 3.8 3.4e-37 127.4 3.8 1.2 1 0 0 1 1 1 1 Ribosomal protein L6e C2 PF00168.30 EDO16094.1 - 1.9e-62 208.0 0.4 2.7e-19 69.4 0.0 5.6 5 0 0 5 5 5 5 C2 domain Dor1 PF04124.12 EDO16095.1 - 2.3e-35 121.9 6.6 1.7e-34 119.0 6.6 2.1 1 1 0 1 1 1 1 Dor1-like family ANAPC3 PF12895.7 EDO16095.1 - 0.05 13.8 0.1 1 9.6 0.0 2.7 1 1 1 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 LBP_M PF17385.2 EDO16096.1 - 0.012 15.2 0.4 0.053 13.0 0.4 1.9 1 1 0 1 1 1 0 Lacto-N-biose phosphorylase central domain COPIIcoated_ERV PF07970.12 EDO16097.1 - 1.5e-33 116.5 0.0 2.4e-33 115.9 0.0 1.2 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 EDO16097.1 - 2.2e-24 85.6 0.0 4.2e-24 84.7 0.0 1.5 1 0 0 1 1 1 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) UBA_6 PF18039.1 EDO16097.1 - 0.12 12.4 0.0 0.34 10.9 0.0 1.8 1 0 0 1 1 1 0 UBA-like domain SUR7 PF06687.12 EDO16098.1 - 5.2e-08 32.8 3.8 8.2e-08 32.1 3.8 1.3 1 0 0 1 1 1 1 SUR7/PalI family Orf78 PF06024.12 EDO16098.1 - 0.26 11.6 2.7 0.37 11.1 0.8 2.3 1 1 1 2 2 2 0 Orf78 (ac78) DUF2231 PF09990.9 EDO16098.1 - 0.35 11.3 3.0 8.8 6.8 0.1 2.4 2 0 0 2 2 2 0 Predicted membrane protein (DUF2231) MLANA PF14991.6 EDO16098.1 - 0.44 10.8 0.0 0.44 10.8 0.0 1.9 2 0 0 2 2 2 0 Protein melan-A AAA_lid_10 PF17872.1 EDO16099.1 - 2.3e-39 133.5 2.9 2.6e-39 133.4 0.1 2.6 2 0 0 2 2 2 1 AAA lid domain AAA PF00004.29 EDO16099.1 - 6.7e-20 71.9 0.1 4.8e-19 69.1 0.0 2.4 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EDO16099.1 - 3.3e-08 34.1 0.0 6.4e-07 29.9 0.0 2.8 3 0 0 3 3 3 1 AAA ATPase domain BAH PF01426.18 EDO16099.1 - 2.4e-07 30.6 0.1 6.1e-07 29.3 0.1 1.7 1 0 0 1 1 1 1 BAH domain AAA_22 PF13401.6 EDO16099.1 - 4.9e-06 26.9 0.0 3.4e-05 24.1 0.0 2.4 2 0 0 2 2 2 1 AAA domain ATPase_2 PF01637.18 EDO16099.1 - 0.00019 21.4 0.1 0.00019 21.4 0.1 4.1 4 1 0 4 4 4 1 ATPase domain predominantly from Archaea AAA_18 PF13238.6 EDO16099.1 - 0.0075 16.8 0.4 0.53 10.8 0.0 3.3 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 EDO16099.1 - 0.016 15.6 0.3 0.065 13.6 0.0 2.1 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 EDO16099.1 - 0.037 14.0 0.0 0.095 12.6 0.0 1.6 1 1 0 1 1 1 0 NACHT domain RNA_helicase PF00910.22 EDO16099.1 - 0.051 14.0 0.0 0.73 10.3 0.0 2.9 2 0 0 2 2 2 0 RNA helicase AAA_11 PF13086.6 EDO16099.1 - 0.14 11.9 12.9 0.69 9.6 0.0 2.9 3 0 0 3 3 3 0 AAA domain Ribosomal_S3Ae PF01015.18 EDO16100.1 - 8.8e-87 289.9 5.5 1e-86 289.7 5.5 1.0 1 0 0 1 1 1 1 Ribosomal S3Ae family Abhydro_lipase PF04083.16 EDO16100.1 - 0.017 14.7 0.0 0.064 12.8 0.0 2.0 2 0 0 2 2 2 0 Partial alpha/beta-hydrolase lipase region PIF1 PF05970.14 EDO16101.1 - 1.3e-74 251.6 1.7 5.3e-55 187.1 0.4 2.3 1 1 1 2 2 2 2 PIF1-like helicase AAA_30 PF13604.6 EDO16101.1 - 1.9e-18 66.9 0.0 3.2e-18 66.2 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EDO16101.1 - 3.3e-09 37.2 0.0 7.1e-09 36.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EDO16101.1 - 1.3e-05 25.5 0.0 4.5e-05 23.7 0.0 1.9 1 0 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 EDO16101.1 - 0.0013 18.6 0.1 0.43 10.3 0.1 2.8 2 1 0 2 2 2 1 Viral (Superfamily 1) RNA helicase Herpes_Helicase PF02689.14 EDO16101.1 - 0.003 15.6 0.1 0.022 12.7 0.0 2.0 2 0 0 2 2 2 1 Helicase RNA_helicase PF00910.22 EDO16101.1 - 0.0032 17.8 0.1 0.03 14.7 0.0 2.7 2 0 0 2 2 2 1 RNA helicase AAA_7 PF12775.7 EDO16101.1 - 0.0041 16.6 0.0 0.0095 15.5 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_32 PF13654.6 EDO16101.1 - 0.0067 15.3 0.4 0.015 14.1 0.1 1.7 2 0 0 2 2 2 1 AAA domain UvrD_C_2 PF13538.6 EDO16101.1 - 0.012 15.5 0.0 0.025 14.4 0.0 1.6 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain AAA_5 PF07728.14 EDO16101.1 - 0.015 15.3 0.0 0.045 13.7 0.0 1.9 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA PF00004.29 EDO16101.1 - 0.026 14.9 0.0 0.11 12.9 0.0 2.1 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) partial_CstF PF15861.5 EDO16101.1 - 0.043 13.6 0.1 0.18 11.6 0.1 2.2 1 0 0 1 1 1 0 Partial cleavage stimulation factor domain T2SSE PF00437.20 EDO16101.1 - 0.048 12.7 0.0 0.085 11.9 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein Helicase_RecD PF05127.14 EDO16101.1 - 0.051 13.4 0.1 0.23 11.3 0.1 2.1 1 1 0 1 1 1 0 Helicase TrwB_AAD_bind PF10412.9 EDO16101.1 - 0.084 11.8 0.1 0.15 10.9 0.1 1.3 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain Mg_chelatase PF01078.21 EDO16101.1 - 0.11 11.9 0.0 0.25 10.7 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI PhoH PF02562.16 EDO16101.1 - 0.11 11.9 0.3 0.65 9.4 0.0 2.3 2 0 0 2 2 2 0 PhoH-like protein AAA_16 PF13191.6 EDO16101.1 - 0.16 12.3 0.1 0.37 11.2 0.1 1.5 1 0 0 1 1 1 0 AAA ATPase domain DUF104 PF01954.16 EDO16101.1 - 0.18 12.3 2.0 0.73 10.3 0.1 3.0 2 0 0 2 2 2 0 Protein of unknown function DUF104 DUF2075 PF09848.9 EDO16101.1 - 2.6 7.2 8.0 0.11 11.7 0.2 2.8 4 1 0 4 4 4 0 Uncharacterized conserved protein (DUF2075) OGG_N PF07934.12 EDO16102.1 - 2.2e-21 76.2 0.2 1.2e-20 73.8 0.1 2.1 2 0 0 2 2 2 1 8-oxoguanine DNA glycosylase, N-terminal domain HhH-GPD PF00730.25 EDO16102.1 - 2.9e-20 72.7 0.0 4.9e-20 72.0 0.0 1.4 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein MRP-L47 PF06984.13 EDO16103.1 - 2.8e-24 85.1 0.9 6.1e-24 84.0 0.9 1.6 1 0 0 1 1 1 1 Mitochondrial 39-S ribosomal protein L47 (MRP-L47) DUF883 PF05957.13 EDO16103.1 - 0.059 14.0 1.3 0.2 12.3 0.1 2.2 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF883) Phage_GPO PF05929.11 EDO16103.1 - 0.78 9.3 5.0 0.55 9.8 1.2 2.0 2 0 0 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase LSM PF01423.22 EDO16104.1 - 1.2e-18 66.6 0.3 1.3e-18 66.4 0.3 1.1 1 0 0 1 1 1 1 LSM domain DUF150_C PF17384.2 EDO16104.1 - 0.0048 17.0 0.0 0.016 15.3 0.0 1.7 1 1 1 2 2 2 1 RimP C-terminal SH3 domain Patatin PF01734.22 EDO16105.1 - 6.2e-19 69.0 0.4 1.6e-11 44.8 0.4 2.5 2 0 0 2 2 2 2 Patatin-like phospholipase cNMP_binding PF00027.29 EDO16105.1 - 3.1e-16 59.2 0.0 4.7e-15 55.4 0.0 2.7 3 0 0 3 3 3 1 Cyclic nucleotide-binding domain cNMP_binding PF00027.29 EDO16106.1 - 2.7e-05 24.1 0.0 4.1 7.5 0.0 3.7 4 0 0 4 4 4 3 Cyclic nucleotide-binding domain Hid1 PF12722.7 EDO16107.1 - 5.6e-61 206.7 62.3 8.4e-36 123.5 8.7 4.6 2 1 2 4 4 4 2 High-temperature-induced dauer-formation protein WGG PF10273.9 EDO16108.1 - 1.5e-27 96.1 0.9 2.2e-27 95.5 0.2 1.7 2 0 0 2 2 2 1 Pre-rRNA-processing protein TSR2 Metallophos PF00149.28 EDO16109.1 - 1.7e-35 123.4 0.1 3.3e-35 122.4 0.1 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase IMPDH PF00478.25 EDO16110.1 - 9.3e-124 412.9 4.9 1.1e-123 412.7 4.9 1.0 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain CBS PF00571.28 EDO16110.1 - 1.9e-14 53.8 0.0 6.1e-06 26.6 0.0 2.5 2 0 0 2 2 2 2 CBS domain NMO PF03060.15 EDO16110.1 - 4.1e-07 29.7 6.0 0.0016 17.9 4.3 2.9 2 1 1 3 3 3 2 Nitronate monooxygenase FMN_dh PF01070.18 EDO16110.1 - 1.8e-06 27.2 1.8 4.5e-06 25.9 1.8 1.6 1 1 0 1 1 1 1 FMN-dependent dehydrogenase His_biosynth PF00977.21 EDO16110.1 - 0.0033 16.9 0.6 0.014 14.9 0.6 1.9 1 1 0 1 1 1 1 Histidine biosynthesis protein DUF1899 PF08953.11 EDO16111.1 - 1.1e-32 111.6 0.9 2.2e-32 110.7 0.9 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1899) WD40_4 PF16300.5 EDO16111.1 - 9.1e-20 70.3 0.2 2.2e-19 69.1 0.2 1.6 1 0 0 1 1 1 1 Type of WD40 repeat WD40 PF00400.32 EDO16111.1 - 4.5e-17 62.1 3.2 9.1e-05 23.2 0.0 5.4 5 0 0 5 5 5 3 WD domain, G-beta repeat Nup160 PF11715.8 EDO16111.1 - 1.4e-08 33.9 0.3 7.1e-05 21.7 0.1 2.2 1 1 1 2 2 2 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 EDO16111.1 - 3.7e-05 23.9 0.1 0.0072 16.6 0.2 3.6 2 1 2 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EDO16111.1 - 0.00099 19.0 0.1 0.15 11.9 0.0 2.7 2 0 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 EDO16111.1 - 0.0024 16.9 0.0 0.65 8.9 0.0 2.5 1 1 2 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein TMF_DNA_bd PF12329.8 EDO16111.1 - 5.9 7.0 9.8 0.56 10.3 3.0 2.3 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding zf-C3HC4 PF00097.25 EDO16112.1 - 1.2e-05 25.1 9.4 3.2e-05 23.7 9.4 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EDO16112.1 - 3e-05 23.9 8.8 8.4e-05 22.4 8.8 1.8 1 1 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EDO16112.1 - 3.1e-05 23.9 9.5 7.4e-05 22.7 9.5 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.6 EDO16112.1 - 3.9e-05 23.9 9.0 9.2e-05 22.7 9.0 1.7 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 EDO16112.1 - 0.0012 18.7 9.6 0.0058 16.5 9.6 2.1 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EDO16112.1 - 0.035 13.9 12.0 0.023 14.5 6.6 2.4 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EDO16112.1 - 0.16 12.2 11.1 0.061 13.5 7.5 2.1 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 EDO16112.1 - 0.19 11.6 14.2 2.2 8.2 0.1 3.0 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 CNH PF00780.22 EDO16113.1 - 1.4e-12 47.8 2.1 3.3e-12 46.6 2.1 1.6 1 1 0 1 1 1 1 CNH domain RhoGEF PF00621.20 EDO16113.1 - 5.5e-10 39.8 1.6 6.8e-10 39.5 0.1 2.0 2 0 0 2 2 2 1 RhoGEF domain PH_5 PF15405.6 EDO16113.1 - 1.5e-06 28.3 3.5 9.9e-05 22.5 0.3 3.5 2 1 0 2 2 2 1 Pleckstrin homology domain CSM2 PF16834.5 EDO16113.1 - 0.031 13.9 0.1 0.09 12.4 0.1 1.7 1 0 0 1 1 1 0 Shu complex component Csm2, DNA-binding PH PF00169.29 EDO16113.1 - 0.076 13.5 1.1 0.27 11.7 0.1 2.5 2 0 0 2 2 2 0 PH domain HSF_DNA-bind PF00447.17 EDO16113.1 - 0.19 12.4 2.1 0.35 11.5 0.3 2.4 2 0 0 2 2 2 0 HSF-type DNA-binding LRR_4 PF12799.7 EDO16114.1 - 4.3e-31 106.4 89.3 1.9e-08 34.5 3.7 7.4 1 1 10 11 11 11 11 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EDO16114.1 - 9.9e-24 82.9 38.2 1.4e-11 44.0 1.5 6.3 4 1 2 6 6 6 6 Leucine rich repeat LRR_9 PF14580.6 EDO16114.1 - 1.6e-17 63.5 25.7 3.4e-07 29.9 0.7 4.4 1 1 3 4 4 4 3 Leucine-rich repeat LRR_6 PF13516.6 EDO16114.1 - 0.00029 20.7 18.1 9.2 6.6 0.1 7.2 5 1 1 6 6 6 1 Leucine Rich repeat LRR_1 PF00560.33 EDO16114.1 - 0.0011 19.2 35.6 0.64 10.8 0.1 9.7 9 2 0 9 9 9 3 Leucine Rich Repeat LRR_5 PF13306.6 EDO16114.1 - 0.024 14.6 1.5 0.024 14.6 1.5 3.3 1 1 4 5 5 5 0 BspA type Leucine rich repeat region (6 copies) DUF4897 PF16238.5 EDO16114.1 - 0.1 12.4 2.1 0.17 11.7 0.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4897) LRR_2 PF07723.13 EDO16114.1 - 0.11 13.2 0.6 21 6.0 0.0 4.3 4 0 0 4 4 4 0 Leucine Rich Repeat Latarcin PF10279.9 EDO16114.1 - 0.24 11.8 3.4 51 4.4 3.4 3.8 1 1 0 1 1 1 0 Latarcin precursor Amidohydro_2 PF04909.14 EDO16115.1 - 2e-06 27.8 0.0 8.5e-06 25.8 0.0 1.9 1 1 1 2 2 2 1 Amidohydrolase DUF3627 PF12299.8 EDO16115.1 - 0.085 13.0 0.3 0.22 11.6 0.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3627) HATPase_c_2 PF13581.6 EDO16115.1 - 0.18 11.7 0.0 0.32 11.0 0.0 1.3 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain Mo25 PF08569.11 EDO16116.1 - 1.8e-07 30.8 0.0 2e-07 30.7 0.0 1.0 1 0 0 1 1 1 1 Mo25-like Mtr2 PF10429.9 EDO16117.1 - 9.5e-71 237.0 0.1 1.1e-70 236.8 0.1 1.0 1 0 0 1 1 1 1 Nuclear pore RNA shuttling protein Mtr2 Pribosyl_synth PF14572.6 EDO16118.1 - 1.2e-38 133.0 0.4 1.5e-29 103.4 0.1 2.3 2 0 0 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran_N PF13793.6 EDO16118.1 - 1.1e-37 128.5 0.0 3.1e-37 127.1 0.0 1.8 1 0 0 1 1 1 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyltran PF00156.27 EDO16118.1 - 2.6e-06 27.1 0.0 0.018 14.6 0.0 2.4 2 0 0 2 2 2 2 Phosphoribosyl transferase domain DUF4050 PF13259.6 EDO16119.1 - 2.4e-09 37.8 0.6 2.4e-09 37.8 0.6 2.7 1 1 2 3 3 3 2 Protein of unknown function (DUF4050) Ribosomal_L7Ae PF01248.26 EDO16120.1 - 2e-23 81.9 0.3 3.2e-23 81.3 0.3 1.3 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family RNase_P_pop3 PF08228.11 EDO16120.1 - 0.00089 19.3 0.1 0.0022 18.1 0.1 1.8 1 1 0 1 1 1 1 RNase P subunit Pop3 AMPK1_CBM PF16561.5 EDO16120.1 - 0.07 13.3 0.0 0.13 12.4 0.0 1.4 1 0 0 1 1 1 0 Glycogen recognition site of AMP-activated protein kinase FGGY_C PF02782.16 EDO16121.1 - 3.4e-74 248.9 0.3 5.2e-74 248.3 0.3 1.3 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.21 EDO16121.1 - 2.2e-46 158.4 0.1 1.3e-37 129.7 0.0 3.0 2 1 0 2 2 2 2 FGGY family of carbohydrate kinases, N-terminal domain Autophagy_act_C PF03987.15 EDO16122.1 - 3e-09 37.3 0.6 7.8e-09 36.0 0.6 1.8 1 1 0 1 1 1 1 Autophagocytosis associated protein, active-site domain Fer2_3 PF13085.6 EDO16123.1 - 2.7e-33 114.2 0.1 4.2e-33 113.6 0.1 1.3 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Fer4_17 PF13534.6 EDO16123.1 - 1.9e-09 37.9 6.9 1.9e-09 37.9 6.9 2.1 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_8 PF13183.6 EDO16123.1 - 1.4e-08 35.1 7.3 1.4e-08 35.1 7.3 2.5 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_10 PF13237.6 EDO16123.1 - 3.1e-07 30.4 3.1 3.1e-07 30.4 3.1 2.2 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer2 PF00111.27 EDO16123.1 - 0.00024 21.0 3.5 0.011 15.7 0.8 2.4 2 0 0 2 2 2 2 2Fe-2S iron-sulfur cluster binding domain Fer4_7 PF12838.7 EDO16123.1 - 0.0015 19.1 5.5 0.0015 19.1 5.5 2.8 2 2 0 2 2 2 1 4Fe-4S dicluster domain Fer4_9 PF13187.6 EDO16123.1 - 0.0076 16.4 7.1 0.0076 16.4 7.1 2.4 2 1 0 2 2 2 1 4Fe-4S dicluster domain SF3a60_bindingd PF12108.8 EDO16123.1 - 0.062 13.2 0.2 0.12 12.3 0.2 1.5 1 0 0 1 1 1 0 Splicing factor SF3a60 binding domain Ecm29 PF13001.7 EDO16124.1 - 4.6e-156 520.4 22.3 9.4e-154 512.8 2.7 4.3 4 0 0 4 4 4 4 Proteasome stabiliser HEAT PF02985.22 EDO16124.1 - 9.7e-11 41.0 10.9 0.077 13.3 0.0 9.9 11 0 0 11 11 11 3 HEAT repeat Vac14_Fab1_bd PF12755.7 EDO16124.1 - 1.3e-06 28.9 1.1 0.024 15.2 0.0 5.7 4 1 1 5 5 5 2 Vacuolar 14 Fab1-binding region CLASP_N PF12348.8 EDO16124.1 - 0.0034 17.0 7.1 1.5 8.3 0.1 4.9 5 0 0 5 5 5 2 CLASP N terminal Antimicrobial_4 PF08024.11 EDO16124.1 - 0.33 11.1 1.5 1.2 9.3 1.5 1.9 1 0 0 1 1 1 0 Ant antimicrobial peptide ubiquitin PF00240.23 EDO16125.1 - 9.5e-234 755.8 41.8 7.9e-33 112.0 0.6 7.0 7 0 0 7 7 7 7 Ubiquitin family Rad60-SLD PF11976.8 EDO16125.1 - 3.2e-109 356.9 42.8 4.8e-15 55.1 0.7 7.0 7 0 0 7 7 7 7 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EDO16125.1 - 1.8e-37 127.7 23.2 0.00099 19.5 0.1 9.2 7 7 0 7 7 7 7 Ubiquitin-like domain TBK1_ULD PF18396.1 EDO16125.1 - 1.3e-26 92.4 11.0 0.06 13.3 0.0 7.2 7 0 0 7 7 7 7 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_5 PF18037.1 EDO16125.1 - 3.3e-24 85.1 19.8 0.068 13.5 0.1 7.1 7 0 0 7 7 7 7 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 EDO16125.1 - 1.3e-22 79.9 10.4 0.29 11.3 0.0 8.1 7 0 0 7 7 7 7 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 EDO16125.1 - 5.4e-21 75.1 6.9 0.73 10.4 0.0 7.2 1 1 4 7 7 7 7 DUF2407 ubiquitin-like domain Methyltrans_RNA PF04452.14 EDO16125.1 - 2.5e-11 43.4 4.8 4.2 6.6 0.0 6.1 6 0 0 6 6 6 6 RNA methyltransferase DUF2870 PF11069.8 EDO16125.1 - 4.8e-10 39.7 0.0 60 4.1 0.0 7.5 7 0 0 7 7 7 0 Protein of unknown function (DUF2870) DUF3861 PF12977.7 EDO16125.1 - 1.8e-08 34.4 10.7 29 4.9 0.0 7.2 7 0 0 7 7 7 0 Domain of Unknown Function with PDB structure (DUF3861) Ubiquitin_4 PF18036.1 EDO16125.1 - 2.2e-08 34.1 48.0 34 4.6 0.2 13.8 14 0 0 14 14 14 0 Ubiquitin-like domain Big_7 PF17957.1 EDO16125.1 - 4.1e-08 33.9 2.9 1.1e+02 3.7 0.0 7.0 7 0 0 7 7 7 0 Bacterial Ig domain ACT_5 PF13710.6 EDO16125.1 - 5.4e-08 32.6 13.7 20 5.1 0.0 7.3 7 0 0 7 7 7 0 ACT domain UDP-g_GGTase PF06427.11 EDO16125.1 - 2.6e-07 30.7 13.8 16 5.7 0.0 6.7 7 0 0 7 7 7 0 UDP-glucose:Glycoprotein Glucosyltransferase DUF969 PF06149.12 EDO16125.1 - 2.7e-07 30.3 0.1 51 3.2 0.0 6.6 7 0 0 7 7 7 0 Protein of unknown function (DUF969) DUF493 PF04359.14 EDO16125.1 - 1e-05 26.0 0.3 2.8e+02 2.2 0.0 6.7 7 0 0 7 7 7 0 Protein of unknown function (DUF493) ORF11CD3 PF10549.9 EDO16125.1 - 1.2e-05 25.3 0.0 1.8e+02 2.3 0.0 6.9 7 0 0 7 7 7 0 ORF11CD3 domain YcgR_2 PF12945.7 EDO16125.1 - 0.00015 21.9 16.8 58 3.9 0.1 7.2 7 0 0 7 7 7 0 Flagellar protein YcgR ACT_4 PF13291.6 EDO16125.1 - 0.00079 20.0 6.5 2.8e+02 2.2 0.0 6.9 7 0 0 7 7 7 0 ACT domain Baculo_p48 PF04878.13 EDO16125.1 - 0.0017 17.4 0.0 1.4e+02 1.2 0.0 5.4 6 0 0 6 6 6 0 Baculovirus P48 protein Myosin_N PF02736.19 EDO16125.1 - 0.39 10.6 14.7 2.1e+02 1.9 0.0 7.9 7 0 0 7 7 7 0 Myosin N-terminal SH3-like domain ProRS-C_2 PF09181.10 EDO16125.1 - 0.42 10.8 16.1 2.1e+02 2.2 0.1 6.8 7 0 0 7 7 7 0 Prolyl-tRNA synthetase, C-terminal HAMP_N3 PF18575.1 EDO16125.1 - 0.59 9.7 7.6 3.8e+02 0.8 0.0 6.1 7 0 0 7 7 7 0 HAMP N-terminal domain 3 Tash_PEST PF07708.11 EDO16125.1 - 0.65 10.2 53.5 12 6.2 1.4 7.3 7 0 0 7 7 7 0 Tash protein PEST motif CorA PF01544.18 EDO16125.1 - 6 6.1 6.5 5.2e+02 -0.3 0.0 5.3 7 0 0 7 7 7 0 CorA-like Mg2+ transporter protein CAF-1_p150 PF11600.8 EDO16126.1 - 0.0017 18.0 37.0 0.0017 18.0 37.0 4.0 3 1 1 4 4 4 1 Chromatin assembly factor 1 complex p150 subunit, N-terminal MDM10 PF12519.8 EDO16127.1 - 2e-135 452.3 20.6 2.3e-135 452.1 20.6 1.0 1 0 0 1 1 1 1 Mitochondrial distribution and morphology protein 10 RRP7 PF12923.7 EDO16127.1 - 0.038 14.1 0.6 0.077 13.1 0.6 1.4 1 0 0 1 1 1 0 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain Spo7 PF03907.13 EDO16128.1 - 1.2e-72 244.0 7.6 1.5e-72 243.7 7.6 1.1 1 0 0 1 1 1 1 Spo7-like protein DUF5090 PF17009.5 EDO16128.1 - 1.5 8.8 8.2 1.9 8.4 7.6 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF5090) WD40 PF00400.32 EDO16129.1 - 3.2e-35 119.6 28.2 2.1e-06 28.3 0.5 8.4 7 1 0 7 7 7 6 WD domain, G-beta repeat F-box-like PF12937.7 EDO16129.1 - 1e-14 54.2 2.6 2e-14 53.2 2.6 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EDO16129.1 - 2.2e-11 43.3 1.7 4.7e-11 42.3 1.7 1.6 1 0 0 1 1 1 1 F-box domain Nup160 PF11715.8 EDO16129.1 - 6.1e-11 41.7 7.0 0.0052 15.5 0.1 5.7 4 2 2 6 6 6 4 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 EDO16129.1 - 1.4e-06 28.5 0.3 2.9 8.2 0.0 5.4 2 2 3 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EDO16129.1 - 0.00028 20.3 1.2 0.31 10.3 0.0 3.4 2 1 2 4 4 4 1 WD40-like domain F-box_4 PF15966.5 EDO16129.1 - 0.0053 16.6 0.1 0.016 15.1 0.1 1.8 1 0 0 1 1 1 1 F-box PRANC PF09372.10 EDO16129.1 - 0.05 13.9 0.4 0.05 13.9 0.4 2.6 2 1 0 2 2 2 0 PRANC domain CBM_21 PF03370.13 EDO16130.1 - 1.5e-30 105.6 3.4 1.5e-30 105.6 3.4 1.9 2 0 0 2 2 2 1 Carbohydrate/starch-binding module (family 21) CBM53 PF16760.5 EDO16130.1 - 1.6e-10 41.4 3.4 3.2e-10 40.5 3.4 1.5 1 0 0 1 1 1 1 Starch/carbohydrate-binding module (family 53) Mito_carr PF00153.27 EDO16131.1 - 4.8e-46 154.6 3.2 1.3e-16 60.2 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein ArfGap PF01412.18 EDO16132.1 - 2.6e-37 127.5 0.3 2.6e-37 127.5 0.3 1.9 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf AA_kinase PF00696.28 EDO16133.1 - 7.5e-39 133.8 0.0 1.6e-38 132.7 0.0 1.6 1 0 0 1 1 1 1 Amino acid kinase family ACT PF01842.25 EDO16133.1 - 5.4e-13 48.5 0.4 1.3e-05 24.8 0.1 3.1 3 0 0 3 3 3 2 ACT domain ACT_7 PF13840.6 EDO16133.1 - 3.3e-09 36.4 1.5 1.6e-06 27.8 0.3 2.5 2 0 0 2 2 2 2 ACT domain FAD_binding_6 PF00970.24 EDO16134.1 - 1.5e-31 108.6 0.0 2.4e-31 108.0 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.21 EDO16134.1 - 4.7e-28 98.0 0.0 7.5e-28 97.4 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.12 EDO16134.1 - 4.4e-06 26.9 0.0 8e-05 22.8 0.0 2.2 2 0 0 2 2 2 1 Ferric reductase NAD binding domain Cupin_8 PF13621.6 EDO16135.1 - 6.2e-07 29.4 2.5 7.5e-06 25.8 2.5 2.5 1 1 0 1 1 1 1 Cupin-like domain PHD PF00628.29 EDO16135.1 - 1.2e-05 25.1 5.9 2.8e-05 23.9 5.9 1.7 1 1 0 1 1 1 1 PHD-finger JHD PF17811.1 EDO16135.1 - 5.2e-05 23.7 0.5 0.00015 22.3 0.0 1.9 2 0 0 2 2 2 1 Jumonji helical domain BRX_N PF13713.6 EDO16135.1 - 0.0065 16.2 0.8 0.013 15.2 0.8 1.5 1 0 0 1 1 1 1 Transcription factor BRX N-terminal domain JmjC PF02373.22 EDO16135.1 - 0.0068 16.8 1.1 0.9 10.0 0.0 3.2 2 1 0 2 2 2 1 JmjC domain, hydroxylase Cupin_4 PF08007.12 EDO16135.1 - 0.027 13.9 0.0 0.077 12.4 0.0 1.8 2 0 0 2 2 2 0 Cupin superfamily protein Cupin_1 PF00190.22 EDO16135.1 - 0.086 12.4 0.0 0.15 11.7 0.0 1.3 1 0 0 1 1 1 0 Cupin BAR_2 PF10455.9 EDO16136.1 - 2.2e-86 289.6 20.1 3.5e-86 288.9 14.6 2.2 2 1 0 2 2 2 1 Bin/amphiphysin/Rvs domain for vesicular trafficking BAR PF03114.18 EDO16136.1 - 6.4e-15 55.5 12.7 5.8e-14 52.3 12.0 2.2 1 1 0 1 1 1 1 BAR domain BAR_3 PF16746.5 EDO16136.1 - 9e-05 22.3 6.6 9e-05 22.3 6.6 2.3 2 1 0 2 2 2 1 BAR domain of APPL family LKAAEAR PF15478.6 EDO16136.1 - 0.018 15.3 0.8 0.018 15.3 0.8 1.9 2 0 0 2 2 2 0 Family of unknown function with LKAAEAR motif HSBP1 PF06825.12 EDO16136.1 - 0.045 13.6 0.1 0.2 11.6 0.1 2.1 1 0 0 1 1 1 0 Heat shock factor binding protein 1 Apolipoprotein PF01442.18 EDO16136.1 - 0.13 12.2 11.4 0.13 12.1 0.3 2.7 2 1 0 2 2 2 0 Apolipoprotein A1/A4/E domain Lectin_N PF03954.14 EDO16136.1 - 0.95 9.2 5.8 11 5.7 0.7 2.7 2 0 0 2 2 2 0 Hepatic lectin, N-terminal domain Syntaxin_2 PF14523.6 EDO16136.1 - 1 9.8 17.1 0.065 13.6 1.4 3.8 2 1 1 3 3 3 0 Syntaxin-like protein Ofd1_CTDD PF10637.9 EDO16137.1 - 3e-94 315.1 1.6 5.3e-90 301.2 1.3 2.4 2 0 0 2 2 2 2 Oxoglutarate and iron-dependent oxygenase degradation C-term 2OG-FeII_Oxy_4 PF13661.6 EDO16137.1 - 1.5e-26 92.9 0.0 4.6e-26 91.3 0.0 1.9 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_3 PF13640.6 EDO16137.1 - 1.3e-14 54.9 0.0 2.8e-14 53.8 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.20 EDO16137.1 - 0.015 15.8 0.0 0.039 14.4 0.0 1.8 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily Complex1_LYR PF05347.15 EDO16138.1 - 1.3e-17 63.6 1.2 1.6e-17 63.3 1.2 1.1 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 EDO16138.1 - 0.00019 22.1 0.7 0.00021 22.0 0.7 1.1 1 0 0 1 1 1 1 Complex1_LYR-like DnaJ-X PF14308.6 EDO16139.1 - 2.1e-59 200.5 9.4 2.1e-59 200.5 9.4 1.5 2 0 0 2 2 2 1 X-domain of DnaJ-containing DnaJ PF00226.31 EDO16139.1 - 2.8e-26 91.4 0.9 1.1e-25 89.5 0.3 2.4 2 0 0 2 2 2 1 DnaJ domain PEPCK_N PF17297.2 EDO16139.1 - 0.0068 16.0 0.1 0.011 15.3 0.1 1.3 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase N-terminal domain Ima1_N PF09779.9 EDO16139.1 - 0.37 11.6 3.4 1.4 9.7 0.1 2.5 3 0 0 3 3 3 0 Ima1 N-terminal domain Metallophos PF00149.28 EDO16140.1 - 5e-05 23.9 10.6 0.00011 22.8 10.6 1.6 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase YWFCY PF14293.6 EDO16140.1 - 0.11 12.8 0.3 0.42 11.0 0.3 2.0 1 0 0 1 1 1 0 YWFCY protein AAA PF00004.29 EDO16141.1 - 4.2e-39 134.0 0.0 1.2e-38 132.5 0.0 1.9 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.10 EDO16141.1 - 2.5e-10 40.2 1.8 7.3e-07 29.1 0.0 4.5 4 0 0 4 4 4 1 Vps4 C terminal oligomerisation domain AAA_lid_3 PF17862.1 EDO16141.1 - 3.8e-07 29.8 0.0 8.1e-07 28.8 0.0 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_2 PF07724.14 EDO16141.1 - 2.3e-05 24.6 0.1 8.3e-05 22.8 0.0 2.0 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 EDO16141.1 - 5e-05 23.1 0.0 0.00015 21.6 0.0 1.7 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EDO16141.1 - 0.00012 22.4 4.1 0.0011 19.3 0.2 3.8 4 1 0 4 4 4 1 AAA domain AAA_5 PF07728.14 EDO16141.1 - 0.0014 18.6 0.0 0.0063 16.5 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EDO16141.1 - 0.0014 19.0 0.1 0.008 16.6 0.1 2.0 1 1 1 2 2 2 1 AAA ATPase domain TIP49 PF06068.13 EDO16141.1 - 0.0018 17.6 0.0 0.0033 16.7 0.0 1.3 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_14 PF13173.6 EDO16141.1 - 0.0037 17.3 0.7 0.08 13.0 0.0 3.0 3 0 0 3 3 3 1 AAA domain Mg_chelatase PF01078.21 EDO16141.1 - 0.0047 16.3 0.1 0.011 15.1 0.1 1.6 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 EDO16141.1 - 0.0084 15.8 0.0 0.016 14.9 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein DUF815 PF05673.13 EDO16141.1 - 0.0087 15.2 0.0 0.016 14.4 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_25 PF13481.6 EDO16141.1 - 0.012 15.2 0.1 0.38 10.3 0.0 2.6 1 1 0 2 2 2 0 AAA domain AAA_18 PF13238.6 EDO16141.1 - 0.014 16.0 0.1 0.069 13.7 0.0 2.3 2 1 0 2 2 1 0 AAA domain ATPase_2 PF01637.18 EDO16141.1 - 0.022 14.7 0.0 12 5.7 0.0 3.0 1 1 1 2 2 2 0 ATPase domain predominantly from Archaea AAA_33 PF13671.6 EDO16141.1 - 0.028 14.6 0.0 0.086 13.0 0.0 1.9 2 0 0 2 2 1 0 AAA domain TniB PF05621.11 EDO16141.1 - 0.048 13.1 0.1 5.3 6.4 0.0 3.3 2 1 1 3 3 3 0 Bacterial TniB protein AAA_24 PF13479.6 EDO16141.1 - 0.059 13.1 0.1 0.4 10.4 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 EDO16141.1 - 0.16 12.2 0.6 0.71 10.1 0.1 2.2 2 0 0 2 2 2 0 AAA domain PhoH PF02562.16 EDO16141.1 - 0.19 11.2 0.0 0.42 10.0 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein NOT2_3_5 PF04153.18 EDO16142.1 - 2.6e-18 66.4 0.6 5.2e-18 65.4 0.6 1.5 1 0 0 1 1 1 1 NOT2 / NOT3 / NOT5 family Not3 PF04065.15 EDO16143.1 - 2.9e-81 272.3 28.9 3.8e-81 271.9 28.9 1.2 1 0 0 1 1 1 1 Not1 N-terminal domain, CCR4-Not complex component Syntaxin_2 PF14523.6 EDO16143.1 - 0.0022 18.3 2.5 0.0022 18.3 2.5 3.2 3 1 0 3 3 3 1 Syntaxin-like protein DehI PF10778.9 EDO16143.1 - 0.21 11.7 2.1 14 5.8 0.1 3.0 2 1 1 3 3 3 0 Halocarboxylic acid dehydrogenase DehI Use1 PF09753.9 EDO16143.1 - 0.72 9.5 18.5 0.9 9.2 18.0 1.4 1 1 0 1 1 1 0 Membrane fusion protein Use1 DUF1192 PF06698.11 EDO16143.1 - 1.3 9.2 9.2 0.34 11.0 1.0 3.7 4 0 0 4 4 4 0 Protein of unknown function (DUF1192) DUF4140 PF13600.6 EDO16143.1 - 5.9 7.4 9.2 17 5.9 0.1 3.1 2 1 1 3 3 3 0 N-terminal domain of unknown function (DUF4140) Pex14_N PF04695.13 EDO16144.1 - 0.0035 18.0 1.1 0.0081 16.8 1.1 1.5 1 0 0 1 1 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region DEAD_assoc PF08494.11 EDO16144.1 - 0.061 13.1 0.0 2.7 7.7 0.0 2.6 2 0 0 2 2 2 0 DEAD/H associated MSC PF09402.10 EDO16144.1 - 0.42 10.0 6.9 4.1 6.8 0.2 2.5 2 0 0 2 2 2 0 Man1-Src1p-C-terminal domain Orf78 PF06024.12 EDO16144.1 - 2.6 8.4 7.9 5.2 7.4 0.2 3.2 3 0 0 3 3 3 0 Orf78 (ac78) Roughex PF06020.11 EDO16144.1 - 4 6.4 5.3 6.5 5.7 5.3 1.2 1 0 0 1 1 1 0 Drosophila roughex protein DUF4834 PF16118.5 EDO16144.1 - 9.9 7.2 9.9 3.2 8.8 0.9 3.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) bZIP_1 PF00170.21 EDO16146.1 - 5.8e-15 55.1 4.2 1.4e-14 53.9 4.2 1.7 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 EDO16146.1 - 3.5e-06 27.0 4.7 3.5e-06 27.0 4.7 2.1 2 0 0 2 2 2 1 Basic region leucine zipper bZIP_Maf PF03131.17 EDO16146.1 - 0.034 14.7 1.2 0.034 14.7 1.2 4.0 4 0 0 4 4 4 0 bZIP Maf transcription factor fn3_PAP PF17808.1 EDO16147.1 - 0.15 12.1 0.8 0.44 10.7 0.2 2.0 2 0 0 2 2 2 0 Fn3-like domain from Purple Acid Phosphatase Erg28 PF03694.13 EDO16148.1 - 5.8e-45 152.2 1.3 7.6e-45 151.8 1.3 1.2 1 0 0 1 1 1 1 Erg28 like protein MtN3_slv PF03083.16 EDO16148.1 - 0.0031 17.5 0.9 0.0097 15.9 0.2 1.9 1 1 1 2 2 2 1 Sugar efflux transporter for intercellular exchange cNMP_binding PF00027.29 EDO16149.1 - 3.2e-40 136.1 0.1 1.4e-20 73.1 0.0 2.4 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain RIIa PF02197.17 EDO16149.1 - 1.1e-06 28.2 0.2 3.1e-06 26.8 0.2 1.8 1 0 0 1 1 1 1 Regulatory subunit of type II PKA R-subunit ATP-synt_DE_N PF02823.16 EDO16149.1 - 0.23 11.4 0.5 1.8 8.5 0.1 2.2 2 0 0 2 2 2 0 ATP synthase, Delta/Epsilon chain, beta-sandwich domain SWIRM PF04433.17 EDO16150.1 - 1.7e-28 98.8 0.8 7.4e-28 96.7 0.8 2.2 1 0 0 1 1 1 1 SWIRM domain Myb_DNA-binding PF00249.31 EDO16150.1 - 4.5e-09 36.4 0.0 1e-08 35.2 0.0 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain ZZ PF00569.17 EDO16150.1 - 3.1e-08 33.3 2.1 5.1e-08 32.6 2.1 1.3 1 0 0 1 1 1 1 Zinc finger, ZZ type Myb_DNA-bind_6 PF13921.6 EDO16150.1 - 4.4e-07 30.1 2.1 1.1e-06 28.8 0.1 2.8 4 0 0 4 4 4 1 Myb-like DNA-binding domain SWIRM-assoc_1 PF16495.5 EDO16150.1 - 6.2e-06 26.1 5.8 6.3e-06 26.1 2.1 2.5 2 0 0 2 2 2 1 SWIRM-associated region 1 PDCD9 PF07147.12 EDO16150.1 - 0.0098 15.2 4.6 0.019 14.2 4.6 1.4 1 0 0 1 1 1 1 Mitochondrial 28S ribosomal protein S30 (PDCD9) Elf1 PF05129.13 EDO16150.1 - 0.01 15.8 0.5 0.024 14.7 0.5 1.6 1 0 0 1 1 1 0 Transcription elongation factor Elf1 like zf-UBR PF02207.20 EDO16150.1 - 0.017 15.3 1.0 0.031 14.4 1.0 1.4 1 0 0 1 1 1 0 Putative zinc finger in N-recognin (UBR box) Zn_ribbon_2 PF12674.7 EDO16150.1 - 0.072 13.7 1.0 0.54 11.0 0.1 2.9 2 0 0 2 2 2 0 Putative zinc ribbon domain zf-CCHC_2 PF13696.6 EDO16150.1 - 0.63 9.9 4.6 3.4 7.6 0.7 2.3 2 0 0 2 2 2 0 Zinc knuckle Zip PF02535.22 EDO16151.1 - 1.7e-60 205.0 8.2 2.4e-60 204.6 8.2 1.2 1 0 0 1 1 1 1 ZIP Zinc transporter CPP1-like PF11833.8 EDO16151.1 - 8 6.1 8.8 1.1 8.9 0.3 3.0 2 1 1 3 3 3 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like AMPK1_CBM PF16561.5 EDO16152.1 - 0.00012 22.3 0.8 0.00028 21.0 0.1 1.9 2 0 0 2 2 2 1 Glycogen recognition site of AMP-activated protein kinase YedD PF13987.6 EDO16152.1 - 0.079 12.8 0.1 0.37 10.6 0.0 1.9 1 1 1 2 2 2 0 YedD-like protein STAG PF08514.11 EDO16153.1 - 9e-26 90.0 3.2 9e-26 90.0 3.2 3.6 4 0 0 4 4 4 1 STAG domain HEAT PF02985.22 EDO16153.1 - 0.0086 16.3 0.0 2.3 8.7 0.0 3.7 3 0 0 3 3 3 1 HEAT repeat Ipi1_N PF12333.8 EDO16153.1 - 0.042 14.5 3.7 0.44 11.2 0.1 4.0 4 0 0 4 4 4 0 Rix1 complex component involved in 60S ribosome maturation DUF2857 PF11198.8 EDO16153.1 - 0.098 12.4 0.7 4.2 7.1 0.1 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF2857) Flu_NS2 PF00601.19 EDO16153.1 - 0.9 9.9 11.6 0.056 13.7 1.8 3.7 4 0 0 4 4 4 0 Influenza non-structural protein (NS2) DUF4407 PF14362.6 EDO16153.1 - 5.7 6.2 6.7 0.77 9.0 0.9 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) MMgT PF10270.9 EDO16154.1 - 1.6e-13 50.9 0.2 1.7e-13 50.7 0.2 1.0 1 0 0 1 1 1 1 Membrane magnesium transporter Glyco_hydro_63 PF03200.16 EDO16155.1 - 1.4e-173 578.2 4.2 1.3e-172 575.0 4.2 2.0 1 1 0 1 1 1 1 Glycosyl hydrolase family 63 C-terminal domain Glyco_hydro_63N PF16923.5 EDO16155.1 - 1.1e-62 212.2 0.0 2e-62 211.3 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 63 N-terminal domain GDE_C PF06202.14 EDO16155.1 - 3.2e-05 23.1 0.1 0.00011 21.3 0.1 1.9 1 1 0 1 1 1 1 Amylo-alpha-1,6-glucosidase FlaE PF07559.14 EDO16155.1 - 0.0096 16.5 0.1 0.032 14.8 0.1 1.9 1 1 0 1 1 1 1 Flagellar basal body protein FlaE DUF3841 PF12952.7 EDO16155.1 - 0.48 10.2 7.0 5.7 6.7 0.2 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF3841) Macoilin PF09726.9 EDO16156.1 - 5.5 5.4 19.6 7.2 5.0 19.6 1.1 1 0 0 1 1 1 0 Macoilin family DUF4637 PF15470.6 EDO16156.1 - 7.6 6.2 5.8 13 5.4 5.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) SPX PF03105.19 EDO16156.1 - 8.6 6.2 15.3 12 5.6 15.3 1.2 1 0 0 1 1 1 0 SPX domain rve PF00665.26 EDO16157.1 - 4.9e-15 55.8 0.0 7.1e-15 55.2 0.0 1.1 1 0 0 1 1 1 1 Integrase core domain DUF5084 PF16894.5 EDO16158.1 - 0.2 12.1 1.5 8.7 6.8 0.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF5084) Ribosomal_L7Ae PF01248.26 EDO16159.1 - 8.3e-24 83.2 0.0 9.9e-24 82.9 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Ribosomal_L24e PF01246.20 EDO16160.1 - 5.1e-30 103.5 0.1 5.1e-30 103.5 0.1 2.1 2 1 0 2 2 2 1 Ribosomal protein L24e DUF775 PF05603.12 EDO16160.1 - 0.17 11.4 2.0 0.21 11.1 2.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF775) UNC-79 PF14776.6 EDO16160.1 - 0.19 10.4 1.7 0.23 10.2 1.7 1.0 1 0 0 1 1 1 0 Cation-channel complex subunit UNC-79 DUF1279 PF06916.13 EDO16161.1 - 6.1e-23 81.2 0.0 1.4e-22 80.0 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1279) YpzG PF14139.6 EDO16161.1 - 0.06 13.5 0.0 0.17 12.1 0.0 1.7 1 0 0 1 1 1 0 YpzG-like protein TMEM126 PF07114.11 EDO16163.1 - 0.065 12.6 0.0 0.15 11.5 0.0 1.6 1 0 0 1 1 1 0 Transmembrane protein 126 Gly_transf_sug PF04488.15 EDO16164.1 - 1.1e-14 54.8 0.1 3.8e-14 53.1 0.1 1.9 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif Ras PF00071.22 EDO16165.1 - 1.8e-49 167.5 0.1 2.6e-49 166.9 0.1 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EDO16165.1 - 2.8e-17 63.0 0.0 7.2e-17 61.7 0.0 1.7 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EDO16165.1 - 6.3e-08 32.3 0.1 9.1e-08 31.7 0.1 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EDO16165.1 - 0.00041 20.0 0.9 0.00071 19.2 0.1 1.8 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EDO16165.1 - 0.0032 17.4 1.5 2.2 8.2 0.1 2.8 3 0 0 3 3 3 2 RsgA GTPase SRP-alpha_N PF04086.13 EDO16165.1 - 0.75 9.7 14.4 1.1 9.1 14.4 1.2 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal PALP PF00291.25 EDO16166.1 - 1.5e-58 198.6 0.0 1.9e-58 198.2 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme CBS PF00571.28 EDO16166.1 - 8.4e-19 67.8 0.1 1.1e-11 45.0 0.0 2.7 2 0 0 2 2 2 2 CBS domain ComZ PF10815.8 EDO16167.1 - 0.0042 17.1 0.3 0.0076 16.2 0.3 1.5 1 0 0 1 1 1 1 ComZ Flg_hook PF02120.16 EDO16167.1 - 0.085 12.8 0.4 0.21 11.5 0.1 1.9 2 0 0 2 2 2 0 Flagellar hook-length control protein FliK TFIIS_M PF07500.14 EDO16168.1 - 7.1e-21 74.8 1.9 7.1e-21 74.8 1.9 2.2 2 0 0 2 2 2 1 Transcription factor S-II (TFIIS), central domain TFIIS_C PF01096.18 EDO16168.1 - 3.4e-17 62.0 6.4 3.4e-17 62.0 6.4 2.0 2 0 0 2 2 2 1 Transcription factor S-II (TFIIS) Med26 PF08711.11 EDO16168.1 - 2.3e-10 40.3 2.8 5.2e-10 39.2 2.8 1.7 1 0 0 1 1 1 1 TFIIS helical bundle-like domain HypA PF01155.19 EDO16168.1 - 0.0026 17.8 0.9 0.0026 17.8 0.9 2.1 2 0 0 2 2 2 1 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DUF1670 PF07900.11 EDO16168.1 - 0.0096 15.3 0.4 0.021 14.2 0.4 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1670) ALIX_LYPXL_bnd PF13949.6 EDO16168.1 - 0.061 12.6 5.3 1.2 8.4 1.2 2.3 2 0 0 2 2 2 0 ALIX V-shaped domain binding to HIV Xpo1 PF08389.12 EDO16168.1 - 0.24 11.5 1.3 1.9 8.5 0.8 2.1 2 0 0 2 2 2 0 Exportin 1-like protein Ribosomal_L37ae PF01780.19 EDO16168.1 - 3 8.0 6.7 20 5.4 0.3 3.1 2 1 0 2 2 2 0 Ribosomal L37ae protein family RRM_1 PF00076.22 EDO16169.1 - 2.3e-20 72.2 0.0 4.3e-20 71.3 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CSTF_C PF14304.6 EDO16169.1 - 2.1e-09 36.8 1.4 4.7e-09 35.7 1.4 1.6 1 0 0 1 1 1 1 Transcription termination and cleavage factor C-terminal CSTF2_hinge PF14327.6 EDO16169.1 - 2.9e-08 34.1 0.3 2.9e-08 34.1 0.3 1.9 2 0 0 2 2 2 1 Hinge domain of cleavage stimulation factor subunit 2 Med30 PF11315.8 EDO16169.1 - 0.052 13.8 2.0 0.077 13.2 2.0 1.4 1 0 0 1 1 1 0 Mediator complex subunit 30 RRM_occluded PF16842.5 EDO16169.1 - 0.062 13.2 0.0 0.12 12.3 0.0 1.5 1 0 0 1 1 1 0 Occluded RNA-recognition motif PEMT PF04191.13 EDO16170.1 - 3.2e-57 191.4 14.6 6.4e-35 119.8 1.3 3.4 3 1 1 4 4 4 2 Phospholipid methyltransferase SKICH PF17751.1 EDO16170.1 - 0.0032 18.0 0.2 6.1 7.5 0.0 2.9 2 0 0 2 2 2 2 SKICH domain HECW_N PF16562.5 EDO16170.1 - 0.097 12.5 0.1 0.24 11.2 0.1 1.6 1 0 0 1 1 1 0 N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2 RNase_PH PF01138.21 EDO16171.1 - 1.5e-07 32.0 0.1 2e-07 31.6 0.1 1.2 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 Arrestin_N PF00339.29 EDO16172.1 - 1.9e-18 67.0 0.0 5.6e-18 65.4 0.0 1.9 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 EDO16172.1 - 1.4e-09 38.5 0.7 1.4e-09 38.5 0.7 3.4 3 1 0 3 3 3 2 Arrestin (or S-antigen), C-terminal domain RRM_1 PF00076.22 EDO16173.1 - 4.3e-42 141.8 0.0 6.6e-20 70.7 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EDO16173.1 - 0.0026 17.8 0.0 2 8.6 0.0 2.7 2 1 0 2 2 2 2 RNA recognition motif RRM_5 PF13893.6 EDO16173.1 - 0.0083 15.7 0.0 3.8 7.1 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EDO16173.1 - 0.067 13.2 0.0 12 6.0 0.0 2.3 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif DbpA PF03880.15 EDO16173.1 - 0.082 12.9 0.0 3.9 7.5 0.0 2.3 2 0 0 2 2 2 0 DbpA RNA binding domain Cep57_CLD_2 PF14197.6 EDO16175.1 - 0.018 15.1 4.9 0.042 13.9 4.9 1.7 1 0 0 1 1 1 0 Centrosome localisation domain of PPC89 BST2 PF16716.5 EDO16175.1 - 7.3 7.3 9.1 0.18 12.4 2.2 1.9 3 0 0 3 3 3 0 Bone marrow stromal antigen 2 Glyco_tran_28_C PF04101.16 EDO16176.1 - 1.9e-26 93.0 0.1 2.9e-25 89.2 0.1 1.9 1 1 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain MIF4G PF02854.19 EDO16177.1 - 3.5e-43 147.7 0.5 7.4e-43 146.7 0.5 1.6 1 0 0 1 1 1 1 MIF4G domain eIF_4G1 PF12152.8 EDO16177.1 - 1.2e-24 86.2 1.1 1.2e-24 86.2 1.1 2.3 2 0 0 2 2 2 1 Eukaryotic translation initiation factor 4G1 TYW3 PF02676.14 EDO16178.1 - 1.5e-66 223.8 0.0 2e-66 223.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase TYW3 Gtr1_RagA PF04670.12 EDO16179.1 - 4.4e-67 225.8 0.8 6.3e-67 225.3 0.8 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Arf PF00025.21 EDO16179.1 - 0.0015 18.0 0.0 0.0036 16.8 0.0 1.7 1 1 0 1 1 1 1 ADP-ribosylation factor family AAA_14 PF13173.6 EDO16179.1 - 0.09 12.8 0.0 0.22 11.6 0.0 1.8 1 0 0 1 1 1 0 AAA domain AsnC_trans_reg PF01037.21 EDO16179.1 - 0.096 12.7 0.0 0.27 11.2 0.0 1.7 1 0 0 1 1 1 0 Lrp/AsnC ligand binding domain Aconitase PF00330.20 EDO16181.1 - 3.4e-152 507.7 0.0 4.3e-152 507.3 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 EDO16181.1 - 4.2e-45 153.3 0.0 7.5e-45 152.5 0.0 1.4 1 0 0 1 1 1 1 Aconitase C-terminal domain Polysacc_deac_1 PF01522.21 EDO16182.1 - 3.6e-25 88.3 0.0 5.6e-25 87.6 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide deacetylase GRIP PF01465.20 EDO16183.1 - 9.7e-14 51.0 0.2 2.3e-13 49.8 0.2 1.7 1 0 0 1 1 1 1 GRIP domain ATG16 PF08614.11 EDO16183.1 - 0.00037 20.8 149.6 0.029 14.6 19.8 8.3 1 1 7 8 8 8 5 Autophagy protein 16 (ATG16) Tho2 PF11262.8 EDO16183.1 - 0.0046 16.2 10.0 0.0046 16.2 10.0 9.3 1 1 8 9 9 9 1 Transcription factor/nuclear export subunit protein 2 GvpK PF05121.12 EDO16183.1 - 0.01 15.8 1.2 0.01 15.8 1.2 6.8 7 3 1 8 8 8 0 Gas vesicle protein K CENP-F_leu_zip PF10473.9 EDO16183.1 - 1.4 9.0 174.2 0.026 14.6 20.9 9.3 2 2 7 9 9 9 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 RasGEF PF00617.19 EDO16184.1 - 8e-55 185.8 1.0 8e-55 185.8 1.0 2.8 3 0 0 3 3 3 1 RasGEF domain RasGEF_N PF00618.20 EDO16184.1 - 4.1e-07 30.2 0.4 4.1e-07 30.2 0.4 4.3 3 1 0 3 3 3 1 RasGEF N-terminal motif SH3_1 PF00018.28 EDO16184.1 - 6.8e-06 25.6 0.6 2.1e-05 24.0 0.2 2.0 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 EDO16184.1 - 8.7e-05 22.3 0.1 0.00019 21.3 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EDO16184.1 - 0.0015 18.1 0.1 0.0051 16.5 0.1 1.8 1 0 0 1 1 1 1 Variant SH3 domain tRNA-synt_2 PF00152.20 EDO16185.1 - 1.1e-45 156.1 2.6 1.9e-45 155.3 2.6 1.3 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 EDO16185.1 - 2.1e-08 34.0 0.1 5.4e-08 32.7 0.1 1.8 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain SPC25 PF06703.11 EDO16186.1 - 7.9e-41 139.5 3.3 9e-41 139.4 3.3 1.0 1 0 0 1 1 1 1 Microsomal signal peptidase 25 kDa subunit (SPC25) adh_short PF00106.25 EDO16187.1 - 1.8e-26 92.8 0.1 2.3e-26 92.5 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EDO16187.1 - 1.2e-14 54.5 0.0 1.4e-14 54.2 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EDO16187.1 - 2.5e-05 24.3 0.2 0.00059 19.8 0.2 2.1 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 EDO16187.1 - 0.0029 17.1 0.0 0.2 11.1 0.0 2.1 2 0 0 2 2 2 2 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EDO16187.1 - 0.03 13.3 0.4 0.046 12.7 0.4 1.4 1 1 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family PfaD_N PF18328.1 EDO16187.1 - 0.14 12.1 0.0 0.31 11.0 0.0 1.5 1 0 0 1 1 1 0 Fatty acid synthase subunit PfaD N-terminal domain FMN_dh PF01070.18 EDO16188.1 - 3.1e-118 394.8 0.0 3.8e-118 394.5 0.0 1.1 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Cyt-b5 PF00173.28 EDO16188.1 - 1.3e-18 66.9 0.0 3.2e-18 65.6 0.0 1.7 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Glu_synthase PF01645.17 EDO16188.1 - 1.8e-07 30.6 0.0 3.7e-07 29.6 0.0 1.4 1 0 0 1 1 1 1 Conserved region in glutamate synthase IMPDH PF00478.25 EDO16188.1 - 0.0059 15.7 0.1 0.0059 15.7 0.1 2.9 3 1 1 4 4 4 1 IMP dehydrogenase / GMP reductase domain NMO PF03060.15 EDO16188.1 - 0.013 14.9 0.2 0.031 13.7 0.2 1.7 1 1 0 1 1 1 0 Nitronate monooxygenase ThiG PF05690.14 EDO16188.1 - 0.11 11.8 0.0 2.7 7.2 0.0 2.2 2 0 0 2 2 2 0 Thiazole biosynthesis protein ThiG Dus PF01207.17 EDO16188.1 - 0.12 11.5 0.0 3.2 6.7 0.0 2.3 2 0 0 2 2 2 0 Dihydrouridine synthase (Dus) His_biosynth PF00977.21 EDO16188.1 - 0.14 11.6 0.3 16 4.8 0.0 2.5 2 1 0 2 2 2 0 Histidine biosynthesis protein DUF3755 PF12579.8 EDO16188.1 - 7.1 6.4 6.1 1.1 8.9 0.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3755) Citrate_synt PF00285.21 EDO16189.1 - 5.9e-101 338.1 0.0 7.3e-101 337.8 0.0 1.1 1 0 0 1 1 1 1 Citrate synthase, C-terminal domain SCP2_2 PF13530.6 EDO16189.1 - 0.15 12.5 0.0 0.27 11.6 0.0 1.4 1 0 0 1 1 1 0 Sterol carrier protein domain Pkinase PF00069.25 EDO16190.1 - 1.2e-50 172.3 0.0 2.1e-50 171.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO16190.1 - 4.8e-27 94.9 0.0 7.2e-27 94.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EDO16190.1 - 0.0034 17.3 0.0 0.014 15.3 0.0 1.8 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.6 EDO16190.1 - 0.02 14.2 0.0 0.3 10.4 0.0 2.2 2 0 0 2 2 2 0 Kinase-like Haspin_kinase PF12330.8 EDO16190.1 - 0.031 13.2 0.7 0.097 11.6 0.0 1.8 1 1 1 2 2 2 0 Haspin like kinase domain RIO1 PF01163.22 EDO16190.1 - 0.037 13.6 0.2 0.086 12.4 0.0 1.6 2 0 0 2 2 2 0 RIO1 family Kdo PF06293.14 EDO16190.1 - 0.046 13.1 0.0 0.075 12.4 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 EDO16190.1 - 0.048 13.2 0.0 0.1 12.2 0.0 1.5 1 0 0 1 1 1 0 Choline/ethanolamine kinase BAR PF03114.18 EDO16191.1 - 9.8e-56 189.1 2.6 1.1e-55 188.8 2.6 1.0 1 0 0 1 1 1 1 BAR domain DUF1496 PF07383.12 EDO16191.1 - 0.0058 16.2 0.7 0.014 15.0 0.7 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1496) MgtE_N PF03448.17 EDO16191.1 - 0.054 14.1 0.2 0.42 11.2 0.0 2.5 3 0 0 3 3 3 0 MgtE intracellular N domain PRD PF00874.20 EDO16191.1 - 0.1 12.9 0.5 0.67 10.3 0.0 2.3 2 0 0 2 2 2 0 PRD domain Seryl_tRNA_N PF02403.22 EDO16191.1 - 0.14 12.4 2.9 2.3 8.5 0.5 2.5 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain DUF4164 PF13747.6 EDO16191.1 - 0.19 12.0 1.9 0.23 11.8 0.5 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4164) BRE1 PF08647.11 EDO16191.1 - 7.9 6.6 10.7 17 5.5 3.8 2.4 2 0 0 2 2 2 0 BRE1 E3 ubiquitin ligase Gpr1_Fun34_YaaH PF01184.19 EDO16192.1 - 2.5e-91 304.9 22.1 2.9e-91 304.7 22.1 1.0 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family RNA_pol_Rpc34 PF05158.12 EDO16193.1 - 2e-117 392.3 3.4 2.3e-117 392.1 3.4 1.0 1 0 0 1 1 1 1 RNA polymerase Rpc34 subunit Rrf2 PF02082.20 EDO16193.1 - 0.037 14.4 1.2 0.063 13.6 0.2 2.0 2 0 0 2 2 2 0 Transcriptional regulator HTH_3 PF01381.22 EDO16193.1 - 0.052 13.6 0.4 0.16 12.1 0.2 1.9 2 0 0 2 2 2 0 Helix-turn-helix Pox_polyA_pol_C PF12629.7 EDO16193.1 - 0.19 11.5 3.8 0.078 12.8 0.4 1.9 2 1 0 2 2 2 0 Poxvirus poly(A) polymerase C-terminal domain B-block_TFIIIC PF04182.12 EDO16193.1 - 0.3 11.3 2.5 1.8 8.8 0.2 2.4 1 1 1 2 2 2 0 B-block binding subunit of TFIIIC HAD PF12710.7 EDO16194.1 - 1.5e-05 25.5 0.0 0.00057 20.3 0.0 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Swi5 PF07061.11 EDO16194.1 - 0.073 13.2 0.0 0.13 12.3 0.0 1.4 1 0 0 1 1 1 0 Swi5 TPR_14 PF13428.6 EDO16195.1 - 2.4e-07 31.0 0.0 0.47 11.4 0.0 5.2 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 EDO16195.1 - 5.9e-07 29.9 0.2 0.052 14.1 0.1 4.1 2 1 2 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 EDO16195.1 - 1.2e-06 28.2 5.7 0.033 14.4 0.0 4.6 5 0 0 5 5 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 EDO16195.1 - 2.3e-05 24.1 6.4 0.0093 16.0 0.0 5.3 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_1 PF00515.28 EDO16195.1 - 7.6e-05 22.4 1.6 0.52 10.2 0.0 5.0 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_12 PF13424.6 EDO16195.1 - 9.2e-05 22.7 6.0 0.24 11.7 0.0 5.3 5 1 0 5 5 5 1 Tetratricopeptide repeat TPR_16 PF13432.6 EDO16195.1 - 0.0012 19.4 1.2 3.3 8.4 0.0 4.2 4 1 1 5 5 4 1 Tetratricopeptide repeat TPR_17 PF13431.6 EDO16195.1 - 0.0043 17.3 1.4 2.1 8.9 0.0 4.1 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_11 PF13414.6 EDO16195.1 - 0.0061 16.2 0.0 4 7.2 0.0 3.8 2 1 1 3 3 3 1 TPR repeat RPN7 PF10602.9 EDO16195.1 - 0.047 13.4 0.9 1.2 8.8 0.1 3.1 3 0 0 3 3 3 0 26S proteasome subunit RPN7 ANAPC3 PF12895.7 EDO16195.1 - 0.079 13.2 5.0 4.9 7.4 0.1 3.8 3 1 0 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 EDO16195.1 - 0.087 12.9 0.9 41 4.5 0.1 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat Pex14_N PF04695.13 EDO16196.1 - 0.2 12.3 7.8 0.32 11.6 7.8 1.3 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Zip PF02535.22 EDO16196.1 - 6.8 5.8 7.2 9.5 5.3 7.2 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter 60KD_IMP PF02096.20 EDO16196.1 - 8.3 6.3 15.3 0.51 10.2 0.4 2.2 2 0 0 2 2 2 0 60Kd inner membrane protein Spt20 PF12090.8 EDO16196.1 - 8.9 5.8 23.8 26 4.3 0.1 2.5 2 0 0 2 2 2 0 Spt20 family ATP11 PF06644.11 EDO16197.1 - 4.1e-92 308.8 0.5 4.9e-92 308.6 0.5 1.0 1 0 0 1 1 1 1 ATP11 protein zf-rbx1 PF12678.7 EDO16198.1 - 6.5e-24 84.0 13.9 1e-23 83.3 13.9 1.3 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 EDO16198.1 - 3e-17 62.4 9.8 3.8e-17 62.1 9.8 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_2 PF13639.6 EDO16198.1 - 4.3e-06 27.0 14.3 0.00022 21.5 14.3 2.3 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 EDO16198.1 - 0.0006 19.6 12.7 0.0039 17.0 12.7 2.1 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EDO16198.1 - 0.00066 19.5 4.0 0.00066 19.5 4.0 2.6 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EDO16198.1 - 0.002 17.8 1.0 0.002 17.8 1.0 2.6 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4_4 PF15227.6 EDO16198.1 - 0.13 12.5 7.7 0.18 12.0 0.4 2.4 2 1 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.6 EDO16198.1 - 0.3 11.0 10.9 0.89 9.5 4.6 2.5 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) FANCL_C PF11793.8 EDO16198.1 - 0.69 10.1 9.7 3.1 8.0 9.9 2.0 1 1 1 2 2 2 0 FANCL C-terminal domain zf-RING_5 PF14634.6 EDO16198.1 - 1.1 9.3 11.5 5.8 7.0 11.5 2.3 1 1 1 2 2 2 0 zinc-RING finger domain Zn_ribbon_17 PF17120.5 EDO16198.1 - 1.5 8.5 14.7 0.16 11.6 5.1 2.3 1 1 1 2 2 2 0 Zinc-ribbon, C4HC2 type zf-RING-like PF08746.11 EDO16198.1 - 2 8.8 12.2 28 5.1 12.2 2.3 1 1 0 1 1 1 0 RING-like domain zf-RING_UBOX PF13445.6 EDO16198.1 - 3 7.9 10.4 11 6.2 10.1 2.1 1 1 0 1 1 1 0 RING-type zinc-finger Med7 PF05983.11 EDO16199.1 - 1.2e-28 100.6 1.4 1.3e-28 100.4 1.4 1.0 1 0 0 1 1 1 1 MED7 protein CREPT PF16566.5 EDO16199.1 - 0.05 13.8 0.6 0.067 13.4 0.6 1.3 1 1 0 1 1 1 0 Cell-cycle alteration and expression-elevated protein in tumour DUF4665 PF15679.5 EDO16199.1 - 0.08 13.6 0.9 13 6.4 0.1 2.0 1 1 0 2 2 2 0 Domain of unknown function (DUF4665) WD40 PF00400.32 EDO16200.1 - 1.5e-30 104.8 12.2 8e-06 26.5 0.6 7.1 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDO16200.1 - 8.3e-16 58.1 0.2 0.083 13.2 0.0 6.0 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EDO16200.1 - 0.002 17.2 1.1 3.4 6.6 0.0 4.3 1 1 3 5 5 5 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Frtz PF11768.8 EDO16200.1 - 0.0025 16.2 0.0 0.076 11.3 0.0 2.3 1 1 1 2 2 2 2 WD repeat-containing and planar cell polarity effector protein Fritz MFS_1 PF07690.16 EDO16201.1 - 7.7e-18 64.5 34.0 4.7e-16 58.7 15.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EDO16202.1 - 3.5e-123 411.8 31.7 5.3e-123 411.2 31.7 1.3 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDO16202.1 - 1.2e-23 83.7 34.5 1.7e-19 69.9 24.0 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF1213 PF06740.12 EDO16202.1 - 1.5 9.4 3.1 1.1 9.9 0.5 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1213) IF4E PF01652.18 EDO16203.1 - 1.1e-52 178.1 0.3 1.4e-52 177.7 0.3 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E Na_Ca_ex PF01699.24 EDO16204.1 - 1e-18 67.7 34.6 8.7e-15 55.0 14.9 4.0 5 0 0 5 5 5 2 Sodium/calcium exchanger protein YccF PF03733.13 EDO16204.1 - 2.6e-07 31.3 7.9 2.6e-07 31.3 7.9 5.4 6 0 0 6 6 6 1 Inner membrane component domain PsbX PF06596.11 EDO16204.1 - 1.4 9.0 4.5 7.9 6.6 4.5 2.4 1 0 0 1 1 1 0 Photosystem II reaction centre X protein (PsbX) Aminotran_3 PF00202.21 EDO16205.1 - 5.3e-129 430.4 0.0 6.6e-129 430.1 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_5 PF00266.19 EDO16205.1 - 0.028 13.4 0.0 0.049 12.6 0.0 1.4 1 1 0 1 1 1 0 Aminotransferase class-V LCM PF04072.14 EDO16206.1 - 6.1e-21 75.2 0.0 1.3e-20 74.1 0.0 1.6 1 0 0 1 1 1 1 Leucine carboxyl methyltransferase Kelch_4 PF13418.6 EDO16206.1 - 2.6e-18 65.7 3.1 1.2e-09 38.0 0.0 5.9 6 0 0 6 6 6 3 Galactose oxidase, central domain Kelch_6 PF13964.6 EDO16206.1 - 5e-09 36.1 3.5 0.0056 16.9 0.0 5.8 5 1 1 6 6 6 2 Kelch motif Kelch_5 PF13854.6 EDO16206.1 - 1.3e-08 34.6 0.0 0.029 14.3 0.0 5.4 5 0 0 5 5 5 2 Kelch motif Kelch_3 PF13415.6 EDO16206.1 - 1.4e-05 25.2 0.0 0.35 11.2 0.0 4.0 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_1 PF01344.25 EDO16206.1 - 0.00048 19.7 6.2 0.069 12.7 0.0 4.4 4 1 0 4 4 4 2 Kelch motif Kelch_2 PF07646.15 EDO16206.1 - 0.00066 19.5 1.8 0.041 13.9 0.0 4.3 5 0 0 5 5 5 1 Kelch motif Syja_N PF02383.18 EDO16207.1 - 5.2e-75 252.7 0.2 8.9e-75 252.0 0.2 1.4 1 0 0 1 1 1 1 SacI homology domain KH_6 PF15985.5 EDO16208.1 - 1.4e-14 54.1 0.0 2.4e-14 53.4 0.0 1.4 1 0 0 1 1 1 1 KH domain Rrp40_N PF18311.1 EDO16208.1 - 1.7e-10 40.7 0.0 2.9e-10 39.9 0.0 1.4 1 0 0 1 1 1 1 Exosome complex exonuclease Rrp40 N-terminal domain E1_UFD PF09358.10 EDO16208.1 - 0.0012 19.4 0.0 0.0029 18.2 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin fold domain DHHC PF01529.20 EDO16209.1 - 8.9e-36 122.9 16.4 8.9e-36 122.9 16.4 2.3 2 1 0 2 2 2 1 DHHC palmitoyltransferase Flocculin_t3 PF13928.6 EDO16210.1 - 0.00036 21.0 8.3 0.00036 21.0 8.3 13.1 6 4 2 8 8 8 4 Flocculin type 3 repeat FTP PF07504.13 EDO16210.1 - 0.11 12.3 7.1 9.6 6.1 0.0 5.0 5 0 0 5 5 5 0 Fungalysin/Thermolysin Propeptide Motif AAA PF00004.29 EDO16211.1 - 5.5e-56 188.6 0.0 2.6e-44 150.9 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EDO16211.1 - 1.1e-08 34.7 0.0 9.3e-07 28.6 0.0 2.8 3 0 0 3 3 2 1 AAA+ lid domain AAA_16 PF13191.6 EDO16211.1 - 1.3e-05 25.7 0.0 0.05 14.0 0.0 3.5 3 0 0 3 3 3 1 AAA ATPase domain RNA_helicase PF00910.22 EDO16211.1 - 0.00027 21.3 0.0 0.019 15.4 0.0 3.0 3 0 0 3 3 2 1 RNA helicase RuvB_N PF05496.12 EDO16211.1 - 0.00028 20.7 0.0 0.00089 19.0 0.0 1.9 2 0 0 2 2 1 1 Holliday junction DNA helicase RuvB P-loop domain Parvo_NS1 PF01057.17 EDO16211.1 - 0.00028 20.1 0.0 0.0011 18.2 0.0 1.9 2 0 0 2 2 2 1 Parvovirus non-structural protein NS1 AAA_2 PF07724.14 EDO16211.1 - 0.00035 20.7 0.0 0.0088 16.2 0.0 2.9 3 1 0 3 3 2 1 AAA domain (Cdc48 subfamily) ATPase PF06745.13 EDO16211.1 - 0.0013 18.2 0.2 0.034 13.5 0.0 2.5 2 0 0 2 2 2 1 KaiC AAA_7 PF12775.7 EDO16211.1 - 0.0018 17.8 0.1 0.0091 15.5 0.0 2.2 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_18 PF13238.6 EDO16211.1 - 0.0018 18.8 0.8 0.46 11.0 0.0 3.3 3 0 0 3 3 2 1 AAA domain AAA_22 PF13401.6 EDO16211.1 - 0.0056 17.0 0.3 0.21 11.9 0.0 3.2 2 1 1 3 3 3 1 AAA domain AAA_5 PF07728.14 EDO16211.1 - 0.0068 16.4 0.0 0.045 13.7 0.0 2.5 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) TIP49 PF06068.13 EDO16211.1 - 0.0076 15.5 0.2 0.039 13.1 0.0 2.2 2 0 0 2 2 2 1 TIP49 P-loop domain AAA_28 PF13521.6 EDO16211.1 - 0.017 15.4 0.1 0.79 9.9 0.0 2.3 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 EDO16211.1 - 0.018 14.7 0.0 0.038 13.7 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein Mg_chelatase PF01078.21 EDO16211.1 - 0.021 14.2 0.3 0.052 12.9 0.1 1.7 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI PPV_E1_C PF00519.17 EDO16211.1 - 0.033 13.0 0.4 1.7 7.4 0.0 2.6 3 0 0 3 3 3 0 Papillomavirus helicase AAA_33 PF13671.6 EDO16211.1 - 0.036 14.2 0.0 0.98 9.6 0.0 2.5 2 0 0 2 2 2 0 AAA domain TsaE PF02367.17 EDO16211.1 - 0.052 13.5 0.0 0.36 10.8 0.0 2.1 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_14 PF13173.6 EDO16211.1 - 0.065 13.3 0.0 0.61 10.1 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 EDO16211.1 - 0.07 12.9 0.1 1 9.0 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 EDO16211.1 - 0.079 12.5 0.9 1.4 8.4 0.0 2.7 2 1 1 3 3 3 0 AAA domain PhoH PF02562.16 EDO16211.1 - 0.092 12.2 0.0 0.19 11.2 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein Vps4_C PF09336.10 EDO16211.1 - 0.096 12.7 0.1 0.43 10.6 0.1 2.2 1 0 0 1 1 1 0 Vps4 C terminal oligomerisation domain Plk4_PB1 PF18190.1 EDO16211.1 - 1.5 9.0 4.2 3.8 7.7 0.4 3.1 3 0 0 3 3 3 0 Polo-like Kinase 4 Polo Box 1 TPR_2 PF07719.17 EDO16212.1 - 8.4e-30 100.5 40.0 6.8e-05 22.7 0.0 13.2 14 1 1 15 15 14 10 Tetratricopeptide repeat TPR_1 PF00515.28 EDO16212.1 - 1.8e-27 93.9 43.5 5e-07 29.3 0.0 13.4 13 1 1 14 14 14 8 Tetratricopeptide repeat TPR_12 PF13424.6 EDO16212.1 - 5.5e-27 93.9 18.5 6e-08 32.9 0.3 10.3 11 1 0 11 11 11 6 Tetratricopeptide repeat TPR_16 PF13432.6 EDO16212.1 - 1.7e-18 67.0 0.0 0.0056 17.3 0.0 8.1 8 1 1 9 9 9 4 Tetratricopeptide repeat TPR_14 PF13428.6 EDO16212.1 - 1.2e-15 56.8 5.8 0.027 15.3 0.0 10.6 9 2 4 13 13 11 3 Tetratricopeptide repeat TPR_19 PF14559.6 EDO16212.1 - 5.1e-15 55.7 13.5 0.097 13.2 0.2 10.1 9 1 2 11 11 11 6 Tetratricopeptide repeat TPR_8 PF13181.6 EDO16212.1 - 4.9e-14 51.3 44.1 0.0021 18.1 0.0 13.1 15 0 0 15 15 14 4 Tetratricopeptide repeat TPR_17 PF13431.6 EDO16212.1 - 3.6e-12 45.7 14.4 1.1 9.8 0.0 11.0 11 1 1 12 12 11 2 Tetratricopeptide repeat TPR_7 PF13176.6 EDO16212.1 - 1.6e-10 40.2 15.4 4 7.7 0.0 10.5 10 1 0 10 10 10 3 Tetratricopeptide repeat ANAPC3 PF12895.7 EDO16212.1 - 9.2e-06 25.8 29.5 0.00024 21.2 0.2 8.3 6 3 1 8 8 8 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.6 EDO16212.1 - 1.1e-05 25.0 24.0 0.017 14.8 0.0 8.8 9 2 2 11 11 11 3 TPR repeat TPR_10 PF13374.6 EDO16212.1 - 0.00011 22.0 26.0 1.3 9.0 0.0 10.1 12 0 0 12 12 12 2 Tetratricopeptide repeat TPR_6 PF13174.6 EDO16212.1 - 0.00054 20.4 28.0 6.1 7.7 0.0 12.5 15 0 0 15 15 13 1 Tetratricopeptide repeat PPR PF01535.20 EDO16212.1 - 0.023 14.9 0.9 6.5 7.2 0.0 5.0 5 0 0 5 5 5 0 PPR repeat Fis1_TPR_C PF14853.6 EDO16212.1 - 0.028 14.5 8.3 9.5 6.4 0.0 6.1 7 0 0 7 7 7 0 Fis1 C-terminal tetratricopeptide repeat Aromatic_hydrox PF11723.8 EDO16212.1 - 0.15 11.5 1.1 0.4 10.1 1.1 1.7 1 0 0 1 1 1 0 Homotrimeric ring hydroxylase DCP1 PF06058.13 EDO16213.1 - 5.5e-26 90.8 0.3 2.9e-25 88.5 0.3 2.1 1 1 0 1 1 1 1 Dcp1-like decapping family DUF2185 PF09951.9 EDO16213.1 - 0.046 13.6 0.0 0.091 12.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2185) Kelch_1 PF01344.25 EDO16213.1 - 0.074 12.7 0.4 0.22 11.2 0.4 1.8 1 1 0 1 1 1 0 Kelch motif DUF3445 PF11927.8 EDO16213.1 - 0.1 12.2 0.0 0.15 11.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3445) Glyoxalase PF00903.25 EDO16213.1 - 0.15 12.3 0.0 0.25 11.5 0.0 1.6 1 1 0 1 1 1 0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily GFO_IDH_MocA PF01408.22 EDO16214.1 - 3.5e-23 82.7 0.0 7.1e-23 81.7 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 EDO16214.1 - 4.5e-09 36.3 0.0 9.5e-09 35.3 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain NAD_binding_3 PF03447.16 EDO16214.1 - 0.001 19.7 0.0 0.0021 18.7 0.0 1.5 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain HSP70 PF00012.20 EDO16215.1 - 5.9e-229 761.2 9.9 6.6e-229 761.1 9.9 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EDO16215.1 - 1.2e-16 60.5 1.2 3e-15 55.9 0.5 2.2 2 0 0 2 2 2 2 MreB/Mbl protein FGGY_C PF02782.16 EDO16215.1 - 0.0004 20.2 0.0 0.00083 19.1 0.0 1.5 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FtsA PF14450.6 EDO16215.1 - 2 8.9 9.4 5.2 7.5 0.1 3.7 3 3 0 3 3 3 0 Cell division protein FtsA KH_1 PF00013.29 EDO16216.1 - 4.9e-11 42.3 0.3 9.2e-11 41.4 0.3 1.5 1 0 0 1 1 1 1 KH domain KH_2 PF07650.17 EDO16216.1 - 4.8e-05 23.1 0.1 0.0001 22.1 0.1 1.5 1 0 0 1 1 1 1 KH domain FUSC_2 PF13515.6 EDO16217.1 - 2.5e-07 30.8 26.5 4.5e-07 30.0 7.0 2.5 2 0 0 2 2 2 2 Fusaric acid resistance protein-like ArAE_2 PF10334.9 EDO16217.1 - 9.5e-06 25.6 0.5 0.0011 18.9 0.0 3.2 3 0 0 3 3 3 1 Aromatic acid exporter family member 2 ArAE_2_N PF10337.9 EDO16217.1 - 1.3e-05 24.5 15.8 0.00072 18.7 5.0 2.5 1 1 1 2 2 2 2 Putative ER transporter, 6TM, N-terminal DUF1664 PF07889.12 EDO16217.1 - 0.015 15.3 0.2 0.062 13.3 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Mrx7 PF10906.8 EDO16218.1 - 2.7e-30 104.4 0.9 3.1e-30 104.2 0.9 1.1 1 0 0 1 1 1 1 MIOREX complex component 7 VID27_N PF17748.1 EDO16219.1 - 1.6e-36 125.7 2.7 2.1e-36 125.4 2.7 1.1 1 0 0 1 1 1 1 VID27 N-terminal region LIM_bind PF01803.16 EDO16220.1 - 2.1e-61 207.6 0.0 2.1e-61 207.6 0.0 5.4 3 1 2 5 5 5 1 LIM-domain binding protein RabGAP-TBC PF00566.18 EDO16221.1 - 3.8e-31 108.4 23.8 4.9e-30 104.8 9.9 3.0 2 1 0 3 3 3 2 Rab-GTPase-TBC domain PH_RBD PF12068.8 EDO16221.1 - 0.00028 20.4 0.3 0.00064 19.2 0.3 1.6 1 0 0 1 1 1 1 Rab-binding domain (RBD) YfkD PF14167.6 EDO16221.1 - 0.012 14.8 0.2 0.46 9.6 0.0 2.2 2 0 0 2 2 2 0 YfkD-like protein MgsA_C PF12002.8 EDO16222.1 - 2.1e-53 180.7 0.4 5.2e-53 179.4 0.4 1.6 1 0 0 1 1 1 1 MgsA AAA+ ATPase C terminal AAA_assoc_2 PF16193.5 EDO16222.1 - 1.3e-20 73.5 0.1 4e-20 71.9 0.1 1.8 1 0 0 1 1 1 1 AAA C-terminal domain AAA PF00004.29 EDO16222.1 - 3.9e-17 62.9 0.5 2.7e-16 60.2 0.0 2.2 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 EDO16222.1 - 3.2e-14 53.0 0.0 6.2e-14 52.0 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EDO16222.1 - 1.1e-09 38.9 0.5 8.4e-06 26.3 0.0 2.5 1 1 1 2 2 2 2 AAA ATPase domain AAA_14 PF13173.6 EDO16222.1 - 1.5e-08 34.8 0.0 3.1e-08 33.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 EDO16222.1 - 4.2e-07 30.0 0.0 9.2e-07 28.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 EDO16222.1 - 4.3e-06 26.5 0.0 4.3e-05 23.3 0.0 2.1 1 1 0 1 1 1 1 Sigma-54 interaction domain DUF815 PF05673.13 EDO16222.1 - 4.9e-06 25.9 0.0 8.9e-06 25.0 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_22 PF13401.6 EDO16222.1 - 1e-05 25.8 0.9 0.002 18.4 0.1 2.7 1 1 1 2 2 2 1 AAA domain IstB_IS21 PF01695.17 EDO16222.1 - 7.9e-05 22.5 0.0 0.00013 21.7 0.0 1.3 1 0 0 1 1 1 1 IstB-like ATP binding protein Mg_chelatase PF01078.21 EDO16222.1 - 0.0001 21.8 0.2 0.18 11.1 0.0 2.4 1 1 1 2 2 2 2 Magnesium chelatase, subunit ChlI Bac_DnaA PF00308.18 EDO16222.1 - 0.00011 22.2 0.0 0.00033 20.6 0.0 1.8 2 0 0 2 2 2 1 Bacterial dnaA protein AAA_18 PF13238.6 EDO16222.1 - 0.00019 22.0 0.1 0.0018 18.8 0.0 2.5 3 0 0 3 3 2 1 AAA domain Sigma54_activ_2 PF14532.6 EDO16222.1 - 0.00071 19.7 0.0 0.0015 18.6 0.0 1.5 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_19 PF13245.6 EDO16222.1 - 0.00089 19.6 0.7 0.88 9.9 0.1 2.4 1 1 1 2 2 2 2 AAA domain AAA_7 PF12775.7 EDO16222.1 - 0.0011 18.5 0.4 0.0022 17.5 0.0 1.6 2 0 0 2 2 1 1 P-loop containing dynein motor region AAA_30 PF13604.6 EDO16222.1 - 0.0022 17.7 0.0 0.006 16.3 0.0 1.7 1 1 0 1 1 1 1 AAA domain ResIII PF04851.15 EDO16222.1 - 0.0037 17.3 1.1 0.35 10.8 0.8 2.5 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit AAA_2 PF07724.14 EDO16222.1 - 0.0049 17.0 0.1 0.015 15.4 0.0 1.8 2 0 0 2 2 1 1 AAA domain (Cdc48 subfamily) ABC_tran PF00005.27 EDO16222.1 - 0.006 17.1 0.1 0.018 15.5 0.1 2.1 1 1 0 1 1 1 1 ABC transporter TIP49 PF06068.13 EDO16222.1 - 0.0068 15.7 0.1 0.037 13.3 0.0 1.9 2 1 1 3 3 3 1 TIP49 P-loop domain TniB PF05621.11 EDO16222.1 - 0.0071 15.8 0.1 0.11 11.9 0.0 2.4 1 1 1 2 2 2 1 Bacterial TniB protein zf_UBZ PF18439.1 EDO16222.1 - 0.0078 15.8 0.1 0.018 14.7 0.1 1.6 1 0 0 1 1 1 1 Ubiquitin-Binding Zinc Finger AAA_3 PF07726.11 EDO16222.1 - 0.0087 15.9 0.0 0.049 13.5 0.0 2.1 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) RNF220 PF15926.5 EDO16222.1 - 0.012 15.3 0.3 0.022 14.4 0.3 1.5 1 0 0 1 1 1 0 E3 ubiquitin-protein ligase RNF220 AAA_24 PF13479.6 EDO16222.1 - 0.017 14.8 0.0 0.041 13.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain Roc PF08477.13 EDO16222.1 - 0.021 15.1 0.2 0.44 10.8 0.0 2.4 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase RNA_helicase PF00910.22 EDO16222.1 - 0.022 15.1 0.6 0.072 13.5 0.0 2.2 3 0 0 3 3 1 0 RNA helicase RsgA_GTPase PF03193.16 EDO16222.1 - 0.03 14.2 0.1 0.28 11.1 0.0 2.3 2 0 0 2 2 2 0 RsgA GTPase KAP_NTPase PF07693.14 EDO16222.1 - 0.037 13.3 0.9 1.9 7.6 0.2 2.4 1 1 1 2 2 2 0 KAP family P-loop domain PRP21_like_P PF12230.8 EDO16222.1 - 0.037 13.9 0.2 0.075 12.9 0.2 1.5 1 0 0 1 1 1 0 Pre-mRNA splicing factor PRP21 like protein AAA_33 PF13671.6 EDO16222.1 - 0.039 14.1 0.0 0.12 12.6 0.0 1.8 1 0 0 1 1 1 0 AAA domain KTI12 PF08433.10 EDO16222.1 - 0.039 13.4 1.3 0.15 11.5 0.0 2.5 3 0 0 3 3 3 0 Chromatin associated protein KTI12 AAA_28 PF13521.6 EDO16222.1 - 0.053 13.8 0.0 0.1 12.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 EDO16222.1 - 0.056 13.4 3.1 0.35 10.7 1.0 2.5 2 1 1 3 3 2 0 ATPase domain predominantly from Archaea SRPRB PF09439.10 EDO16222.1 - 0.062 12.7 0.0 0.3 10.5 0.0 2.1 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit NB-ARC PF00931.22 EDO16222.1 - 0.094 11.9 0.0 0.23 10.6 0.0 1.7 1 0 0 1 1 1 0 NB-ARC domain MMR_HSR1 PF01926.23 EDO16222.1 - 0.095 12.8 0.2 0.31 11.1 0.0 2.0 2 0 0 2 2 1 0 50S ribosome-binding GTPase XAF1_C PF18608.1 EDO16222.1 - 0.1 12.2 0.1 0.32 10.6 0.1 1.8 1 0 0 1 1 1 0 XIAP-associated factor 1 C-terminal domain Glyco_transf_22 PF03901.17 EDO16223.1 - 2.4e-87 293.9 27.2 3.2e-87 293.5 27.2 1.1 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family Ras PF00071.22 EDO16225.1 - 4.1e-33 114.3 0.1 5.8e-33 113.8 0.1 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EDO16225.1 - 1.8e-06 28.2 0.0 3.4e-06 27.3 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase DAD PF02109.16 EDO16226.1 - 8.6e-38 129.0 7.5 1.2e-37 128.5 7.5 1.2 1 0 0 1 1 1 1 DAD family PalH PF08733.10 EDO16226.1 - 0.0061 15.6 4.1 0.0066 15.5 4.1 1.1 1 0 0 1 1 1 1 PalH/RIM21 DUF2207 PF09972.9 EDO16226.1 - 0.074 11.8 1.8 0.084 11.6 1.8 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Y_phosphatase2 PF03162.13 EDO16227.1 - 5.6e-56 188.7 0.0 8e-56 188.1 0.0 1.1 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.6 EDO16227.1 - 2.8e-05 24.2 0.0 8.8e-05 22.6 0.0 1.7 1 1 0 1 1 1 1 Tyrosine phosphatase family Serglycin PF04360.12 EDO16227.1 - 0.025 14.5 3.2 0.04 13.9 3.2 1.3 1 0 0 1 1 1 0 Serglycin DSPc PF00782.20 EDO16227.1 - 0.04 13.7 0.0 0.085 12.7 0.0 1.6 2 0 0 2 2 2 0 Dual specificity phosphatase, catalytic domain Pes-10 PF07149.11 EDO16227.1 - 2.6 7.0 11.0 3.2 6.7 11.0 1.2 1 0 0 1 1 1 0 Pes-10 DUF2457 PF10446.9 EDO16227.1 - 4.1 6.4 18.9 5.3 6.1 18.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Mpp10 PF04006.12 EDO16227.1 - 4.8 5.5 13.7 6.7 5.0 13.7 1.1 1 0 0 1 1 1 0 Mpp10 protein NOA36 PF06524.12 EDO16227.1 - 8 5.7 19.2 11 5.2 19.2 1.2 1 0 0 1 1 1 0 NOA36 protein Cwf_Cwc_15 PF04889.12 EDO16227.1 - 8.2 6.1 15.8 11 5.7 15.8 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein ApoO PF09769.9 EDO16228.1 - 3.1e-05 23.9 0.0 0.087 12.8 0.0 3.3 2 1 1 3 3 3 3 Apolipoprotein O Aa_trans PF01490.18 EDO16229.1 - 2.2e-99 333.0 33.4 2.7e-99 332.7 33.4 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein bZIP_2 PF07716.15 EDO16230.1 - 6.3e-05 23.0 3.0 6.3e-05 23.0 3.0 2.0 2 0 0 2 2 2 1 Basic region leucine zipper PspB PF06667.12 EDO16230.1 - 0.33 11.0 1.1 0.91 9.6 1.1 1.7 1 0 0 1 1 1 0 Phage shock protein B TSC22 PF01166.18 EDO16230.1 - 5 7.5 8.1 1 9.8 1.5 3.3 2 1 1 3 3 3 0 TSC-22/dip/bun family RGS PF00615.19 EDO16231.1 - 1.4e-06 28.5 2.9 2.3e-06 27.8 2.9 1.3 1 0 0 1 1 1 1 Regulator of G protein signaling domain KinB_sensor PF16767.5 EDO16231.1 - 0.032 14.7 0.2 0.065 13.7 0.1 1.5 2 0 0 2 2 2 0 Sensor domain of alginate biosynthesis sensor protein KinB HMGL-like PF00682.19 EDO16232.1 - 1.1e-90 303.7 0.0 1.5e-90 303.3 0.0 1.2 1 0 0 1 1 1 1 HMGL-like LeuA_dimer PF08502.10 EDO16232.1 - 4.9e-26 91.2 0.2 1.2e-25 90.0 0.2 1.7 1 0 0 1 1 1 1 LeuA allosteric (dimerisation) domain Syja_N PF02383.18 EDO16233.1 - 7.7e-73 245.6 0.1 1.5e-72 244.6 0.1 1.5 1 0 0 1 1 1 1 SacI homology domain Exo_endo_phos PF03372.23 EDO16233.1 - 3.6e-11 43.0 0.1 6.5e-11 42.2 0.1 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family 5_3_exonuc PF01367.20 EDO16233.1 - 0.11 13.1 0.1 1.4 9.5 0.0 2.5 2 0 0 2 2 2 0 5'-3' exonuclease, C-terminal SAM fold YEATS PF03366.16 EDO16234.1 - 2.5e-36 123.5 0.5 3.9e-36 122.9 0.5 1.3 1 0 0 1 1 1 1 YEATS family TFIIIC_sub6 PF10419.9 EDO16235.1 - 9.1e-23 80.0 6.0 2.4e-22 78.6 6.0 1.7 1 1 0 1 1 1 1 TFIIIC subunit triple barrel domain His_Phos_1 PF00300.22 EDO16235.1 - 2.2e-15 56.9 0.0 7.4e-15 55.2 0.0 1.9 2 0 0 2 2 1 1 Histidine phosphatase superfamily (branch 1) CPSF100_C PF13299.6 EDO16235.1 - 0.11 12.6 4.2 0.23 11.6 4.2 1.5 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal BT1 PF03092.16 EDO16235.1 - 0.35 9.0 0.0 0.35 9.0 0.0 1.9 2 0 0 2 2 2 0 BT1 family DUF3464 PF11947.8 EDO16235.1 - 0.64 9.8 4.2 1.1 9.0 4.2 1.4 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 TRAP_alpha PF03896.16 EDO16235.1 - 1.4 8.0 8.1 2.9 7.0 8.1 1.4 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit RPN2_C PF18004.1 EDO16235.1 - 2.6 8.0 10.9 5.2 7.0 10.9 1.5 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Zip PF02535.22 EDO16235.1 - 2.8 7.1 3.7 4.2 6.5 3.7 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 EDO16235.1 - 5.7 5.6 4.5 7 5.3 4.5 1.2 1 0 0 1 1 1 0 Presenilin PBP1_TM PF14812.6 EDO16235.1 - 7.6 7.0 15.1 2.6 8.5 10.9 2.1 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DNA_pol_phi PF04931.13 EDO16235.1 - 9.7 4.1 18.6 15 3.5 18.6 1.2 1 0 0 1 1 1 0 DNA polymerase phi Maf PF02545.14 EDO16236.1 - 3.7e-38 131.0 0.0 4.4e-38 130.7 0.0 1.0 1 0 0 1 1 1 1 Maf-like protein DUF5494 PF17598.2 EDO16236.1 - 0.028 14.5 0.2 1.6 8.9 0.0 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5494) Cyt-b5 PF00173.28 EDO16237.1 - 2.6e-26 91.6 0.0 3.4e-26 91.2 0.0 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain TGBp3 PF02495.17 EDO16237.1 - 0.24 11.1 1.1 6.1 6.6 0.0 2.3 2 0 0 2 2 2 0 Triple gene block 3 zf-C2H2 PF00096.26 EDO16238.1 - 4e-16 58.5 18.7 4.1e-06 26.9 1.4 3.5 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EDO16238.1 - 3e-11 43.2 20.4 5.3e-08 32.9 1.8 3.8 4 0 0 4 4 4 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 EDO16238.1 - 8.4e-09 35.5 15.8 0.00038 21.1 1.1 3.6 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_6 PF13912.6 EDO16238.1 - 3.9e-05 23.5 14.2 0.0023 17.9 1.2 3.1 3 0 0 3 3 3 2 C2H2-type zinc finger zf-met PF12874.7 EDO16238.1 - 0.0085 16.5 10.9 0.029 14.7 0.7 3.6 3 0 0 3 3 3 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EDO16238.1 - 0.016 15.5 13.0 0.039 14.2 0.7 3.4 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-C2H2_aberr PF17017.5 EDO16238.1 - 0.017 15.3 3.8 0.019 15.1 0.8 2.5 2 0 0 2 2 2 0 Aberrant zinc-finger PyrI_C PF02748.15 EDO16238.1 - 0.045 13.7 2.4 0.98 9.4 0.2 2.8 2 0 0 2 2 2 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-CHCC PF10276.9 EDO16238.1 - 0.12 12.5 0.4 0.12 12.5 0.4 2.2 2 0 0 2 2 2 0 Zinc-finger domain C1_4 PF07975.12 EDO16238.1 - 0.52 10.6 3.0 1.1 9.5 0.8 2.5 2 0 0 2 2 2 0 TFIIH C1-like domain zf-Di19 PF05605.12 EDO16238.1 - 0.86 9.9 4.9 1.8 8.9 4.9 1.6 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding Endonuclease_7 PF02945.15 EDO16238.1 - 2 8.4 6.9 7.7 6.5 6.9 2.0 1 1 0 1 1 1 0 Recombination endonuclease VII zf-BED PF02892.15 EDO16238.1 - 2.9 8.0 11.6 7.8 6.6 3.0 3.2 2 1 1 3 3 3 0 BED zinc finger zf_ZIC PF18366.1 EDO16238.1 - 3.8 7.7 5.3 27 5.0 0.4 3.0 2 1 1 3 3 3 0 Zic proteins zinc finger domain zf-H2C2_5 PF13909.6 EDO16238.1 - 7.8 6.4 9.6 7.7 6.4 2.6 2.7 2 0 0 2 2 2 0 C2H2-type zinc-finger domain FYVE PF01363.21 EDO16238.1 - 8.9 6.5 7.7 42 4.4 7.7 2.1 1 1 0 1 1 1 0 FYVE zinc finger DUF2417 PF10329.9 EDO16240.1 - 6.1e-71 238.6 9.6 7.8e-71 238.2 9.6 1.1 1 0 0 1 1 1 1 Region of unknown function (DUF2417) Abhydrolase_1 PF00561.20 EDO16240.1 - 1.5e-08 34.6 0.2 5.3e-08 32.8 0.2 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EDO16240.1 - 3.6e-06 27.7 0.0 6.2e-06 27.0 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family FHA PF00498.26 EDO16241.1 - 2.7e-15 56.4 0.0 8.4e-15 54.9 0.0 1.9 1 0 0 1 1 1 1 FHA domain zf-RING_11 PF17123.5 EDO16241.1 - 4.8e-11 42.2 10.9 8.3e-11 41.4 10.9 1.4 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_2 PF13639.6 EDO16241.1 - 1.9e-07 31.3 11.3 3.2e-07 30.6 11.3 1.4 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 EDO16241.1 - 0.00057 20.1 7.9 0.0015 18.8 7.9 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 EDO16241.1 - 0.0011 19.0 5.0 0.002 18.1 5.0 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Yop-YscD_cpl PF16697.5 EDO16241.1 - 0.0012 19.2 0.0 0.0038 17.5 0.0 1.9 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain zf-C3HC4 PF00097.25 EDO16241.1 - 0.0014 18.4 10.7 0.0029 17.4 10.7 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EDO16241.1 - 0.0085 16.0 8.3 0.014 15.3 8.3 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 EDO16241.1 - 0.012 15.5 10.7 0.02 14.8 10.7 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Sec_GG PF07549.14 EDO16241.1 - 0.11 12.0 0.2 0.2 11.2 0.2 1.4 1 0 0 1 1 1 0 SecD/SecF GG Motif zf-RING_UBOX PF13445.6 EDO16241.1 - 0.32 11.0 9.2 0.7 10.0 9.2 1.6 1 0 0 1 1 1 0 RING-type zinc-finger Malate_synthase PF01274.22 EDO16242.1 - 1.1e-215 716.9 0.0 1.3e-215 716.6 0.0 1.0 1 0 0 1 1 1 1 Malate synthase MTCP1 PF08991.10 EDO16243.1 - 8.2e-07 29.2 3.7 1.2e-06 28.6 3.7 1.3 1 0 0 1 1 1 1 Mature-T-Cell Proliferation I type CHCH PF06747.13 EDO16243.1 - 8.5e-06 25.8 8.7 1.4e-05 25.1 8.7 1.4 1 0 0 1 1 1 1 CHCH domain Pet191_N PF10203.9 EDO16243.1 - 0.018 15.3 4.6 0.028 14.7 4.6 1.4 1 0 0 1 1 1 0 Cytochrome c oxidase assembly protein PET191 Ribosomal_L35p PF01632.19 EDO16244.1 - 4.2e-12 46.4 7.9 5.5e-12 46.0 7.9 1.1 1 0 0 1 1 1 1 Ribosomal protein L35 DSPc PF00782.20 EDO16245.1 - 2e-10 40.6 1.1 4.5e-10 39.5 0.1 2.2 2 1 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EDO16245.1 - 3.8e-05 23.4 1.1 6.3e-05 22.7 0.0 1.9 2 1 1 3 3 3 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 EDO16245.1 - 0.028 14.5 0.0 0.079 13.1 0.0 1.7 1 0 0 1 1 1 0 Inositol hexakisphosphate Y_phosphatase3 PF13350.6 EDO16245.1 - 0.058 13.4 0.0 0.099 12.6 0.0 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family Init_tRNA_PT PF04179.12 EDO16245.1 - 0.095 13.0 0.4 0.47 10.8 0.0 2.2 2 0 0 2 2 2 0 Rit1 DUSP-like domain FeS_assembly_P PF01883.19 EDO16246.1 - 7.7e-08 32.4 0.1 1.4e-07 31.5 0.1 1.4 1 0 0 1 1 1 1 Iron-sulfur cluster assembly protein Tom22 PF04281.13 EDO16247.1 - 2.1e-38 131.3 0.3 2.3e-38 131.1 0.3 1.0 1 0 0 1 1 1 1 Mitochondrial import receptor subunit Tom22 SPEG_u2 PF16650.5 EDO16247.1 - 0.059 13.6 0.2 0.13 12.5 0.2 1.5 1 0 0 1 1 1 0 Unstructured region on SPEG complex protein ADH_zinc_N PF00107.26 EDO16248.1 - 3.2e-13 49.8 0.0 5.9e-13 48.9 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EDO16248.1 - 4.8e-05 23.2 0.1 0.0013 18.5 0.1 2.3 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 EDO16248.1 - 0.0013 19.7 0.0 0.0029 18.6 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase FKBP_C PF00254.28 EDO16250.1 - 5.6e-33 113.1 0.0 6.6e-33 112.9 0.0 1.1 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase Pro_racemase PF05544.11 EDO16250.1 - 0.047 12.7 0.0 0.056 12.5 0.0 1.0 1 0 0 1 1 1 0 Proline racemase Eaf7 PF07904.13 EDO16251.1 - 3.8e-36 123.7 3.7 3.8e-36 123.7 3.7 4.9 5 2 0 5 5 5 1 Chromatin modification-related protein EAF7 ASFV_J13L PF05568.11 EDO16251.1 - 0.015 15.1 0.4 4.5 7.0 0.1 2.6 1 1 1 2 2 2 0 African swine fever virus J13L protein S4 PF01479.25 EDO16252.1 - 2.3e-17 62.4 0.0 5.9e-17 61.1 0.0 1.8 1 0 0 1 1 1 1 S4 domain S4_2 PF13275.6 EDO16252.1 - 0.042 13.7 0.0 0.083 12.7 0.0 1.4 1 0 0 1 1 1 0 S4 domain GN3L_Grn1 PF08701.11 EDO16252.1 - 0.14 12.3 2.7 0.5 10.5 2.7 1.9 1 0 0 1 1 1 0 GNL3L/Grn1 putative GTPase CAP_N PF01213.19 EDO16253.1 - 1.4e-111 373.0 4.7 1.4e-111 373.0 4.7 1.6 1 1 1 2 2 2 1 Adenylate cyclase associated (CAP) N terminal CAP_C PF08603.11 EDO16253.1 - 7.3e-61 204.4 1.4 7.3e-61 204.4 1.4 1.7 2 0 0 2 2 2 1 Adenylate cyclase associated (CAP) C terminal TBCC PF07986.12 EDO16253.1 - 0.19 11.4 1.3 0.4 10.4 1.3 1.5 1 0 0 1 1 1 0 Tubulin binding cofactor C Ribosomal_60s PF00428.19 EDO16253.1 - 2.1 9.0 6.9 7.1 7.3 1.4 2.7 1 1 1 2 2 2 0 60s Acidic ribosomal protein AtuA PF07287.11 EDO16254.1 - 0.066 11.9 0.0 0.11 11.2 0.0 1.3 1 0 0 1 1 1 0 Acyclic terpene utilisation family protein AtuA baeRF_family12 PF18856.1 EDO16254.1 - 0.098 13.2 1.5 0.41 11.2 0.1 2.2 1 1 1 2 2 2 0 Bacterial archaeo-eukaryotic release factor family 12 SF3b10 PF07189.11 EDO16255.1 - 1.5e-30 105.1 0.8 1.8e-30 104.9 0.8 1.0 1 0 0 1 1 1 1 Splicing factor 3B subunit 10 (SF3b10) C2 PF00168.30 EDO16256.1 - 9.8e-07 29.0 0.0 2e-06 28.0 0.0 1.5 1 0 0 1 1 1 1 C2 domain DUF4674 PF15719.5 EDO16256.1 - 0.19 11.7 1.7 0.36 10.8 1.7 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4674) XH PF03469.14 EDO16257.1 - 0.087 12.7 0.2 0.46 10.4 0.2 2.0 2 0 0 2 2 2 0 XH domain PGA2 PF07543.12 EDO16258.1 - 1.5e-11 44.4 11.9 5.8e-07 29.6 0.5 2.3 1 1 1 2 2 2 2 Protein trafficking PGA2 DUF927 PF06048.11 EDO16258.1 - 0.038 13.6 0.3 0.045 13.3 0.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF927) Gam PF06064.11 EDO16258.1 - 0.13 12.5 2.1 0.15 12.3 0.5 1.8 1 1 1 2 2 2 0 Host-nuclease inhibitor protein Gam DivIC PF04977.15 EDO16258.1 - 0.44 10.4 6.9 1.4 8.7 1.2 2.1 2 0 0 2 2 2 0 Septum formation initiator MscS_TM PF12794.7 EDO16258.1 - 1.9 7.3 6.0 6.5 5.5 6.0 1.8 1 1 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 TMEM247 PF15444.6 EDO16258.1 - 2.6 8.0 5.4 0.49 10.4 1.5 1.7 1 1 0 1 1 1 0 Transmembrane protein 247 SUIM_assoc PF16619.5 EDO16258.1 - 5.7 7.1 12.1 2.8 8.1 4.6 2.1 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 DUF5355 PF17306.2 EDO16259.1 - 4.1e-102 341.6 11.8 6e-102 341.1 11.8 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF5355) BRO1 PF03097.18 EDO16259.1 - 0.031 13.1 0.0 0.064 12.0 0.0 1.5 1 0 0 1 1 1 0 BRO1-like domain Acyltransferase PF01553.21 EDO16260.1 - 0.00074 19.1 0.0 0.0054 16.4 0.0 2.1 1 1 0 1 1 1 1 Acyltransferase Acyltransferase PF01553.21 EDO16261.1 - 2.3e-14 53.2 0.1 7.4e-14 51.5 0.0 1.8 2 0 0 2 2 2 1 Acyltransferase Kinesin PF00225.23 EDO16262.1 - 2.1e-101 339.2 4.1 2.1e-101 339.2 4.1 1.9 2 1 1 3 3 3 1 Kinesin motor domain Microtub_bd PF16796.5 EDO16262.1 - 2.5e-56 189.7 0.2 2.5e-56 189.7 0.2 3.3 3 1 0 3 3 3 1 Microtubule binding NPV_P10 PF05531.12 EDO16262.1 - 0.011 16.2 3.1 0.011 16.2 3.1 5.2 4 1 2 6 6 6 0 Nucleopolyhedrovirus P10 protein DUF836 PF05768.14 EDO16262.1 - 0.078 13.4 3.9 8.5 6.9 0.3 3.1 2 1 0 2 2 2 0 Glutaredoxin-like domain (DUF836) Fez1 PF06818.15 EDO16262.1 - 0.64 10.4 45.6 0.085 13.3 25.5 3.3 2 1 1 3 3 3 0 Fez1 Spc7 PF08317.11 EDO16262.1 - 1.4 7.7 48.9 0.21 10.4 16.0 3.2 1 1 2 3 3 3 0 Spc7 kinetochore protein DUF1664 PF07889.12 EDO16262.1 - 1.7 8.7 23.8 1.2 9.2 6.2 4.6 2 1 2 4 4 4 0 Protein of unknown function (DUF1664) Rrp15p PF07890.12 EDO16263.1 - 2.8e-28 98.9 14.7 2.8e-28 98.9 14.7 1.8 2 1 0 2 2 2 1 Rrp15p Glyco_hydro_63 PF03200.16 EDO16263.1 - 0.009 14.8 1.4 0.012 14.4 1.4 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 63 C-terminal domain Amdase PF17645.1 EDO16263.1 - 0.1 12.2 0.0 0.15 11.7 0.0 1.2 1 0 0 1 1 1 0 Arylmalonate decarboxylase DUF2018 PF09442.10 EDO16263.1 - 0.7 10.9 6.1 1.3 10.0 0.2 2.9 2 1 1 3 3 3 0 Domain of unknown function (DUF2018) Ndc1_Nup PF09531.10 EDO16263.1 - 0.87 8.2 2.4 1 8.0 2.4 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup ESP PF16590.5 EDO16263.1 - 1.8 8.9 5.3 0.51 10.6 0.2 2.2 2 1 0 2 2 2 0 Exocrine gland-secreting peptide Metallophos PF00149.28 EDO16264.1 - 3.5e-35 122.4 0.2 5.9e-35 121.6 0.2 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase PPP5 PF08321.12 EDO16264.1 - 1.2e-19 70.4 0.0 9.2e-19 67.5 0.0 2.2 2 0 0 2 2 2 1 PPP5 TPR repeat region TPR_1 PF00515.28 EDO16264.1 - 9.3e-16 56.9 5.2 8.1e-08 31.8 0.1 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 EDO16264.1 - 2e-14 52.4 1.1 5.6e-06 26.1 0.0 3.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 EDO16264.1 - 4.8e-12 45.3 7.8 3.9e-09 36.0 0.2 3.6 4 0 0 4 4 4 2 TPR repeat TPR_8 PF13181.6 EDO16264.1 - 2.5e-07 30.4 3.8 0.0017 18.4 0.1 3.7 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_9 PF13371.6 EDO16264.1 - 2.8e-07 30.6 0.0 0.0063 16.6 0.0 2.5 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.6 EDO16264.1 - 3.8e-07 30.0 3.0 0.00016 21.8 0.3 3.9 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_19 PF14559.6 EDO16264.1 - 0.00024 21.5 0.5 0.0026 18.2 0.5 2.5 2 1 1 3 3 2 1 Tetratricopeptide repeat TPR_7 PF13176.6 EDO16264.1 - 0.00035 20.4 0.1 0.0042 17.0 0.0 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.6 EDO16264.1 - 0.00038 21.1 0.0 0.11 13.2 0.0 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 EDO16264.1 - 0.0045 17.7 0.1 1.1 10.2 0.0 3.4 1 1 2 3 3 3 1 Tetratricopeptide repeat DUF3880 PF12996.7 EDO16264.1 - 0.019 15.0 0.1 0.079 13.0 0.0 2.1 2 0 0 2 2 2 0 DUF based on E. rectale Gene description (DUF3880) TPR_12 PF13424.6 EDO16264.1 - 0.02 15.2 0.4 1.8 8.9 0.0 2.4 1 1 1 2 2 2 0 Tetratricopeptide repeat MIT PF04212.18 EDO16264.1 - 0.02 14.9 1.2 0.039 14.0 0.2 2.0 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain Fis1_TPR_C PF14853.6 EDO16264.1 - 0.051 13.7 1.5 34 4.6 0.0 3.7 2 1 1 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat Sel1 PF08238.12 EDO16264.1 - 0.12 13.1 0.0 0.51 11.1 0.0 2.2 1 0 0 1 1 1 0 Sel1 repeat ANAPC3 PF12895.7 EDO16264.1 - 0.12 12.6 2.1 0.68 10.2 2.0 2.2 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 ATP-synt_DE_N PF02823.16 EDO16265.1 - 5e-11 42.3 0.0 6.9e-11 41.9 0.0 1.3 1 0 0 1 1 1 1 ATP synthase, Delta/Epsilon chain, beta-sandwich domain SET PF00856.28 EDO16266.1 - 1.4e-10 41.8 0.2 1.7e-08 35.0 0.0 2.9 2 1 0 2 2 2 1 SET domain ORC_WH_C PF18137.1 EDO16266.1 - 0.072 13.2 1.4 0.16 12.1 1.4 1.5 1 0 0 1 1 1 0 Origin recognition complex winged helix C-terminal Ribosomal_L4 PF00573.22 EDO16267.1 - 5.3e-44 150.2 2.2 8.6e-44 149.5 2.2 1.3 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family Ribos_L4_asso_C PF14374.6 EDO16267.1 - 3.5e-31 107.1 3.1 6.2e-30 103.1 0.9 2.5 2 0 0 2 2 2 2 60S ribosomal protein L4 C-terminal domain Sld5 PF05916.11 EDO16268.1 - 3.5e-11 43.5 1.3 5.7e-11 42.8 1.3 1.4 1 0 0 1 1 1 1 GINS complex protein PIF1 PF05970.14 EDO16268.1 - 0.00042 19.6 0.2 0.015 14.4 0.0 2.0 1 1 1 2 2 2 2 PIF1-like helicase Occludin_ELL PF07303.13 EDO16268.1 - 0.063 14.0 1.4 0.063 14.0 1.4 2.1 2 1 0 2 2 2 0 Occludin homology domain DASH_Dad3 PF08656.10 EDO16268.1 - 0.81 9.8 0.0 0.81 9.8 0.0 3.3 3 1 0 3 3 3 0 DASH complex subunit Dad3 Wap1 PF16997.5 EDO16269.1 - 3e-126 421.6 31.5 4.8e-126 420.9 31.5 1.3 1 0 0 1 1 1 1 Wap1 domain Swi5 PF07061.11 EDO16269.1 - 0.051 13.7 2.1 0.098 12.7 0.3 2.4 2 0 0 2 2 2 0 Swi5 RusA PF05866.11 EDO16269.1 - 0.068 13.7 1.0 0.14 12.7 0.2 1.9 2 0 0 2 2 2 0 Endodeoxyribonuclease RusA Glyco_hydro_42C PF08533.10 EDO16269.1 - 0.28 10.9 1.0 0.96 9.2 1.0 1.9 1 1 0 1 1 1 0 Beta-galactosidase C-terminal domain PNP_phzG_C PF10590.9 EDO16270.1 - 1e-20 73.5 2.5 2.3e-20 72.4 2.5 1.6 1 0 0 1 1 1 1 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region Putative_PNPOx PF01243.20 EDO16270.1 - 1.1e-11 44.7 0.0 1.6e-11 44.2 0.0 1.2 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase KdpC PF02669.15 EDO16270.1 - 0.05 13.4 0.0 0.093 12.6 0.0 1.4 1 0 0 1 1 1 0 K+-transporting ATPase, c chain Pyridox_oxase_2 PF12766.7 EDO16270.1 - 0.071 13.7 0.1 0.13 12.9 0.1 1.6 1 1 0 1 1 1 0 Pyridoxamine 5'-phosphate oxidase Prefoldin PF02996.17 EDO16271.1 - 2.1e-37 127.7 2.0 4e-37 126.8 2.0 1.5 1 0 0 1 1 1 1 Prefoldin subunit Pox_A_type_inc PF04508.12 EDO16271.1 - 0.0016 18.2 0.1 0.0055 16.5 0.1 1.9 1 0 0 1 1 1 1 Viral A-type inclusion protein repeat SOGA PF11365.8 EDO16271.1 - 0.005 17.9 4.4 0.19 12.9 0.7 2.5 2 1 0 2 2 2 1 Protein SOGA SNAD4 PF18750.1 EDO16271.1 - 0.015 15.4 0.2 0.14 12.3 0.1 2.2 2 0 0 2 2 2 0 Secreted Novel AID/APOBEC-like Deaminase 4 TMPIT PF07851.13 EDO16271.1 - 0.02 14.1 0.9 0.02 14.1 0.9 1.8 2 0 0 2 2 2 0 TMPIT-like protein CENP-F_leu_zip PF10473.9 EDO16271.1 - 0.11 12.5 9.7 0.39 10.7 0.6 2.3 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 RRP36 PF06102.12 EDO16271.1 - 0.86 9.5 7.0 0.91 9.5 0.6 2.1 2 0 0 2 2 2 0 rRNA biogenesis protein RRP36 BST2 PF16716.5 EDO16271.1 - 1.2 9.8 6.4 5 7.8 0.8 2.3 2 0 0 2 2 2 0 Bone marrow stromal antigen 2 zf-C4H2 PF10146.9 EDO16271.1 - 1.5 9.1 6.8 3.1 8.0 6.7 1.6 1 1 0 1 1 1 0 Zinc finger-containing protein Prefoldin_2 PF01920.20 EDO16271.1 - 2.4 8.2 11.1 4.7 7.2 0.2 3.0 1 1 3 4 4 4 0 Prefoldin subunit XhlA PF10779.9 EDO16271.1 - 4 7.7 7.1 8.6 6.6 0.8 2.5 2 0 0 2 2 2 0 Haemolysin XhlA UPF0242 PF06785.11 EDO16271.1 - 4.1 7.5 12.0 0.3 11.2 1.1 2.4 1 1 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus PHB_acc PF05233.13 EDO16273.1 - 0.028 14.4 0.0 10 6.3 0.0 2.6 2 0 0 2 2 2 0 PHB accumulation regulatory domain Mitoc_mL59 PF18126.1 EDO16274.1 - 5.6e-28 97.8 0.7 5.6e-28 97.8 0.7 1.6 1 1 0 1 1 1 1 Mitochondrial ribosomal protein mL59 PRP38 PF03371.15 EDO16275.1 - 6.9e-49 166.0 3.6 8.2e-49 165.8 3.6 1.0 1 0 0 1 1 1 1 PRP38 family Smg4_UPF3 PF03467.15 EDO16276.1 - 4.9e-25 88.5 28.9 4.9e-25 88.5 28.9 3.2 2 1 0 2 2 2 1 Smg-4/UPF3 family DUF1517 PF07466.11 EDO16276.1 - 2.6 8.2 12.1 6.8 6.8 12.1 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1517) PCI PF01399.27 EDO16277.1 - 1.4e-05 25.5 0.1 4.4e-05 23.9 0.1 1.8 1 0 0 1 1 1 1 PCI domain Metallophos PF00149.28 EDO16278.1 - 2.9e-38 132.4 0.1 3.8e-38 132.1 0.1 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 EDO16278.1 - 0.0033 17.8 0.6 0.0071 16.8 0.6 1.5 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain Glyco_hydro_65N PF03636.15 EDO16278.1 - 0.12 12.0 0.0 0.18 11.4 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 65, N-terminal domain E1_DerP2_DerF2 PF02221.15 EDO16279.1 - 1.6e-29 103.1 0.1 1.8e-29 102.9 0.1 1.0 1 0 0 1 1 1 1 ML domain DUF4625 PF15418.6 EDO16279.1 - 0.047 13.9 0.0 0.096 12.9 0.0 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4625) RPAP2_Rtr1 PF04181.13 EDO16280.1 - 1.3e-17 63.9 0.9 2.6e-17 62.9 0.4 1.8 2 0 0 2 2 2 1 Rtr1/RPAP2 family SpoVIF PF14069.6 EDO16280.1 - 0.09 12.6 0.1 7.1 6.5 0.1 2.3 2 0 0 2 2 2 0 Stage VI sporulation protein F CNOT1_CAF1_bind PF16415.5 EDO16280.1 - 0.14 11.5 0.1 0.48 9.8 0.0 1.7 2 0 0 2 2 2 0 CCR4-NOT transcription complex subunit 1 CAF1-binding domain Ribosomal_S13_N PF08069.12 EDO16282.1 - 9.1e-21 73.7 0.0 1.7e-20 72.8 0.0 1.5 1 0 0 1 1 1 1 Ribosomal S13/S15 N-terminal domain Ribosomal_S15 PF00312.22 EDO16282.1 - 4.1e-15 55.8 0.5 7.4e-15 54.9 0.2 1.5 2 0 0 2 2 2 1 Ribosomal protein S15 Cofilin_ADF PF00241.20 EDO16283.1 - 2.2e-16 59.7 0.1 3.2e-16 59.2 0.1 1.2 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein GDI PF00996.18 EDO16284.1 - 8.6e-224 742.9 0.5 9.8e-224 742.7 0.5 1.0 1 0 0 1 1 1 1 GDP dissociation inhibitor NAD_binding_8 PF13450.6 EDO16284.1 - 0.056 13.7 0.0 0.16 12.2 0.0 1.8 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain LSM PF01423.22 EDO16285.1 - 2.1e-19 68.9 0.2 2.6e-19 68.7 0.2 1.1 1 0 0 1 1 1 1 LSM domain Hfq PF17209.3 EDO16285.1 - 0.031 13.9 0.0 0.051 13.2 0.0 1.3 1 0 0 1 1 1 0 Hfq protein Aha1_N PF09229.11 EDO16286.1 - 6.5e-31 107.4 1.3 9.3e-31 106.9 1.3 1.2 1 0 0 1 1 1 1 Activator of Hsp90 ATPase, N-terminal DUF2457 PF10446.9 EDO16286.1 - 0.82 8.7 5.4 1 8.4 5.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Sugar_tr PF00083.24 EDO16287.1 - 2.9e-133 445.0 26.9 3.5e-133 444.8 26.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDO16287.1 - 2e-31 109.2 31.6 7e-31 107.4 26.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 EDO16287.1 - 1.9e-06 26.6 2.4 1.9e-06 26.6 2.4 1.8 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) MFS_3 PF05977.13 EDO16287.1 - 0.0013 17.2 0.5 0.0013 17.2 0.5 1.5 2 0 0 2 2 2 1 Transmembrane secretion effector DUF2530 PF10745.9 EDO16287.1 - 4.8 7.5 6.6 1.9 8.8 1.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2530) HlyIII PF03006.20 EDO16289.1 - 1.8e-49 168.5 21.7 2.3e-49 168.2 21.7 1.1 1 0 0 1 1 1 1 Haemolysin-III related CDC45 PF02724.14 EDO16290.1 - 0.029 12.7 2.9 0.04 12.2 2.9 1.1 1 0 0 1 1 1 0 CDC45-like protein PTPRCAP PF15713.5 EDO16290.1 - 0.1 12.9 5.2 0.21 11.9 5.2 1.5 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated Nop14 PF04147.12 EDO16290.1 - 1.7 6.7 9.1 2.5 6.2 9.1 1.1 1 0 0 1 1 1 0 Nop14-like family SLD5_C PF16922.5 EDO16291.1 - 2.7e-20 72.3 2.5 3.8e-20 71.8 0.2 2.2 2 0 0 2 2 2 1 DNA replication complex GINS protein SLD5 C-terminus Sld5 PF05916.11 EDO16291.1 - 3.1e-11 43.7 0.1 6.9e-11 42.6 0.1 1.6 1 0 0 1 1 1 1 GINS complex protein Methyltransf_23 PF13489.6 EDO16292.1 - 1.1e-23 83.9 0.0 1.7e-23 83.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EDO16292.1 - 9e-18 64.7 0.0 1.7e-17 63.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDO16292.1 - 9.8e-18 64.4 0.0 1.4e-17 63.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EDO16292.1 - 7.5e-17 61.9 0.0 1.3e-16 61.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDO16292.1 - 5.1e-16 59.2 0.0 9.1e-16 58.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 EDO16292.1 - 3.3e-11 43.0 0.0 4.5e-11 42.6 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase PrmA PF06325.13 EDO16292.1 - 3.8e-08 33.1 0.0 5.9e-08 32.4 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) NodS PF05401.11 EDO16292.1 - 1.5e-07 31.2 0.0 2.5e-07 30.5 0.0 1.3 1 0 0 1 1 1 1 Nodulation protein S (NodS) PCMT PF01135.19 EDO16292.1 - 6.5e-07 29.3 0.0 1.4e-05 25.0 0.0 2.2 2 0 0 2 2 2 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) DREV PF05219.12 EDO16292.1 - 7.5e-07 28.5 0.0 1.2e-06 27.8 0.0 1.3 1 0 0 1 1 1 1 DREV methyltransferase RrnaAD PF00398.20 EDO16292.1 - 1.3e-06 27.7 0.1 2e-06 27.1 0.1 1.2 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase MTS PF05175.14 EDO16292.1 - 6.5e-06 25.8 0.0 1.2e-05 24.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Ubie_methyltran PF01209.18 EDO16292.1 - 3.8e-05 23.1 0.0 5.6e-05 22.6 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_18 PF12847.7 EDO16292.1 - 0.00031 20.7 0.0 0.00055 19.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 EDO16292.1 - 0.0013 18.7 0.0 0.0022 18.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Spermine_synth PF01564.17 EDO16292.1 - 0.013 14.9 0.0 0.026 14.0 0.0 1.5 1 0 0 1 1 1 0 Spermine/spermidine synthase domain CheR PF01739.18 EDO16292.1 - 0.017 14.6 0.0 3.1 7.2 0.0 2.5 1 1 1 2 2 2 0 CheR methyltransferase, SAM binding domain Methyltransf_9 PF08003.11 EDO16292.1 - 0.031 13.2 0.0 0.05 12.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) MetW PF07021.12 EDO16292.1 - 0.034 13.7 0.0 0.061 12.9 0.0 1.4 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW Methyltransf_3 PF01596.17 EDO16292.1 - 0.058 12.5 0.0 0.091 11.9 0.0 1.3 1 0 0 1 1 1 0 O-methyltransferase Methyltransf_2 PF00891.18 EDO16292.1 - 0.065 12.5 0.0 0.13 11.6 0.0 1.4 1 0 0 1 1 1 0 O-methyltransferase domain Methyltransf_4 PF02390.17 EDO16292.1 - 0.067 12.7 0.0 0.59 9.6 0.0 2.1 2 0 0 2 2 2 0 Putative methyltransferase Methyltransf_10 PF05971.12 EDO16292.1 - 0.098 12.0 0.0 0.15 11.3 0.0 1.2 1 0 0 1 1 1 0 RNA methyltransferase AviRa PF11599.8 EDO16292.1 - 0.16 11.4 0.0 0.27 10.7 0.0 1.3 1 0 0 1 1 1 0 RRNA methyltransferase AviRa YL1 PF05764.13 EDO16293.1 - 4.7e-38 131.7 79.7 2.5e-30 106.4 37.3 4.2 2 2 2 4 4 4 2 YL1 nuclear protein YL1_C PF08265.11 EDO16293.1 - 6.4e-13 48.2 0.5 1e-12 47.5 0.5 1.4 1 0 0 1 1 1 1 YL1 nuclear protein C-terminal domain UvrD-helicase PF00580.21 EDO16295.1 - 9.1e-30 104.2 1.5 2.4e-14 53.6 0.0 2.8 2 2 1 3 3 3 2 UvrD/REP helicase N-terminal domain AAA_19 PF13245.6 EDO16295.1 - 9.9e-26 90.8 0.0 2.5e-25 89.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain UvrD_C PF13361.6 EDO16295.1 - 9.5e-24 84.4 1.1 9.5e-24 84.4 1.1 1.7 2 0 0 2 2 2 1 UvrD-like helicase C-terminal domain AAA_11 PF13086.6 EDO16295.1 - 5.6e-08 32.9 0.0 1.4e-07 31.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 EDO16295.1 - 4.7e-05 23.2 0.0 0.23 11.1 0.0 3.2 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase ResIII PF04851.15 EDO16295.1 - 0.0054 16.7 0.3 0.02 14.9 0.1 2.3 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 EDO16295.1 - 0.012 15.4 0.0 0.12 12.1 0.0 2.2 2 0 0 2 2 2 0 AAA domain UvrD_C_2 PF13538.6 EDO16295.1 - 0.015 15.1 0.0 0.029 14.2 0.0 1.4 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain Vps52 PF04129.12 EDO16296.1 - 3.2e-144 481.5 20.2 4e-144 481.1 20.2 1.0 1 0 0 1 1 1 1 Vps52 / Sac2 family Spectrin PF00435.21 EDO16296.1 - 0.06 13.8 0.3 0.24 11.9 0.1 2.2 2 0 0 2 2 2 0 Spectrin repeat HalX PF08663.10 EDO16296.1 - 0.072 13.4 0.7 13 6.2 0.1 2.7 2 0 0 2 2 2 0 HalX domain tRNA_m1G_MT PF01746.21 EDO16297.1 - 1.5e-27 96.6 1.7 1.6e-27 96.5 0.2 1.7 2 0 0 2 2 2 1 tRNA (Guanine-1)-methyltransferase VSG_B PF13206.6 EDO16297.1 - 0.029 13.6 2.6 0.037 13.3 2.6 1.2 1 0 0 1 1 1 0 Trypanosomal VSG domain Vma12 PF11712.8 EDO16297.1 - 0.2 11.7 1.3 0.34 11.0 1.3 1.3 1 0 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase AAA_lid_2 PF17863.1 EDO16298.1 - 0.21 11.4 0.0 0.23 11.3 0.0 1.1 1 0 0 1 1 1 0 AAA lid domain ZapB PF06005.12 EDO16299.1 - 0.01 16.3 6.3 0.01 16.3 6.3 4.6 4 1 0 4 4 4 0 Cell division protein ZapB MutS_V PF00488.21 EDO16300.1 - 9.1e-85 283.4 0.3 2e-84 282.3 0.3 1.6 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 EDO16300.1 - 1.7e-33 116.5 3.1 1.7e-33 116.5 3.1 2.6 2 0 0 2 2 2 1 MutS domain III MutS_II PF05188.17 EDO16300.1 - 6.8e-20 71.7 0.1 6.8e-20 71.7 0.1 2.7 4 0 0 4 4 4 1 MutS domain II MutS_IV PF05190.18 EDO16300.1 - 6.6e-18 64.8 0.8 6.6e-18 64.8 0.8 3.0 2 0 0 2 2 2 1 MutS family domain IV MutS_I PF01624.20 EDO16300.1 - 3.1e-10 40.3 0.2 2.8e-09 37.2 0.0 2.4 2 0 0 2 2 2 1 MutS domain I AAA_27 PF13514.6 EDO16300.1 - 0.03 13.9 0.7 0.094 12.3 0.0 2.0 2 0 0 2 2 2 0 AAA domain Cas_DxTHG PF09455.10 EDO16300.1 - 2.1 7.9 17.1 2.9 7.4 2.4 3.0 2 1 0 2 2 2 0 CRISPR-associated (Cas) DxTHG family Suc_Fer-like PF06999.12 EDO16301.1 - 8.2e-49 166.1 0.0 1e-48 165.8 0.0 1.1 1 0 0 1 1 1 1 Sucrase/ferredoxin-like zf-PARP PF00645.18 EDO16301.1 - 0.01 16.7 0.4 0.021 15.6 0.4 1.5 1 0 0 1 1 1 0 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region RibD_C PF01872.17 EDO16302.1 - 1.8e-38 132.4 0.0 2e-38 132.2 0.0 1.0 1 0 0 1 1 1 1 RibD C-terminal domain RSN1_7TM PF02714.15 EDO16303.1 - 3.4e-84 282.4 25.8 6.1e-84 281.6 25.8 1.4 1 0 0 1 1 1 1 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 EDO16303.1 - 9.7e-40 135.9 3.5 9.7e-40 135.9 3.5 3.1 3 0 0 3 3 3 1 Late exocytosis, associated with Golgi transport PHM7_ext PF12621.8 EDO16303.1 - 3.5e-25 88.0 0.0 8.9e-25 86.7 0.0 1.7 1 0 0 1 1 1 1 Extracellular tail, of 10TM putative phosphate transporter PHM7_cyt PF14703.6 EDO16303.1 - 1.3e-14 54.8 0.2 2.8e-14 53.8 0.2 1.6 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter ZZ PF00569.17 EDO16304.1 - 3.7e-08 33.0 9.5 9.3e-08 31.8 9.5 1.7 1 0 0 1 1 1 1 Zinc finger, ZZ type C1_2 PF03107.16 EDO16304.1 - 0.017 15.4 5.8 0.036 14.4 5.8 1.5 1 0 0 1 1 1 0 C1 domain DUF753 PF05444.12 EDO16304.1 - 0.023 14.7 11.1 0.035 14.1 11.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF753) DUF3795 PF12675.7 EDO16304.1 - 0.25 11.8 9.8 0.5 10.8 9.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3795) RasGAP PF00616.19 EDO16305.1 - 1.4e-24 87.0 3.5 1.1e-16 61.2 0.5 3.5 2 1 1 3 3 3 2 GTPase-activator protein for Ras-like GTPase RNase_T PF00929.24 EDO16306.1 - 8.9e-19 68.6 0.6 4.3e-18 66.4 0.0 2.1 2 0 0 2 2 2 1 Exonuclease DNA_pol_A_exo1 PF01612.20 EDO16306.1 - 7.1e-05 22.6 0.0 0.0002 21.1 0.0 1.8 1 1 0 1 1 1 1 3'-5' exonuclease TetR_C_25 PF17933.1 EDO16306.1 - 0.15 12.4 0.0 0.53 10.6 0.0 1.9 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain CRIM PF16978.5 EDO16307.1 - 3.3e-38 131.0 2.0 7e-35 120.2 0.1 2.8 2 0 0 2 2 2 2 SAPK-interacting protein 1 (Sin1), middle CRIM domain SIN1_PH PF16979.5 EDO16307.1 - 6e-32 110.2 5.8 2.1e-31 108.4 0.7 3.7 3 0 0 3 3 3 1 SAPK-interacting protein 1 (Sin1), Pleckstrin-homology RBD PF02196.15 EDO16307.1 - 0.017 15.1 0.0 0.065 13.3 0.0 2.0 1 0 0 1 1 1 0 Raf-like Ras-binding domain Brix PF04427.18 EDO16308.1 - 1.8e-40 139.1 0.3 2.6e-40 138.6 0.3 1.2 1 0 0 1 1 1 1 Brix domain Haem_degrading PF03928.14 EDO16309.1 - 7.2e-26 90.6 0.0 8.7e-26 90.3 0.0 1.1 1 0 0 1 1 1 1 Haem-degrading DUF5482 PF17579.2 EDO16309.1 - 0.072 13.0 0.0 0.14 12.0 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5482) RT_RNaseH PF17917.1 EDO16313.1 - 2.1e-13 50.4 0.0 3.6e-13 49.7 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 EDO16313.1 - 2.2e-12 46.9 0.0 3.7e-12 46.1 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase GFO_IDH_MocA PF01408.22 EDO16315.1 - 2e-08 35.1 0.0 2.9e-08 34.5 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 EDO16315.1 - 0.05 13.6 0.0 0.11 12.5 0.0 1.6 1 0 0 1 1 1 0 Oxidoreductase family, C-terminal alpha/beta domain Hit1_C PF18268.1 EDO16316.1 - 3.4e-40 136.1 2.5 3.4e-40 136.1 2.5 1.5 2 0 0 2 2 2 1 Hit1 C-terminal zf-HIT PF04438.16 EDO16316.1 - 2.4e-11 43.3 12.1 4.5e-11 42.4 12.1 1.5 1 0 0 1 1 1 1 HIT zinc finger YL1_C PF08265.11 EDO16316.1 - 0.0034 17.1 0.0 0.0068 16.1 0.0 1.5 1 0 0 1 1 1 1 YL1 nuclear protein C-terminal domain zf-Mss51 PF13824.6 EDO16316.1 - 0.042 13.9 3.3 0.079 13.1 3.3 1.6 1 0 0 1 1 1 0 Zinc-finger of mitochondrial splicing suppressor 51 zf-MYND PF01753.18 EDO16316.1 - 0.083 13.0 9.1 0.16 12.1 9.1 1.5 1 0 0 1 1 1 0 MYND finger zf-C6H2 PF15801.5 EDO16316.1 - 0.24 11.7 8.1 0.64 10.4 8.1 1.7 1 0 0 1 1 1 0 zf-MYND-like zinc finger, mRNA-binding PolC_DP2 PF03833.13 EDO16316.1 - 0.32 8.8 4.2 0.32 8.8 4.2 1.1 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 MMS1_N PF10433.9 EDO16317.1 - 1.3e-73 248.3 3.2 1.3e-73 248.3 3.2 2.4 3 1 1 4 4 4 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.15 EDO16317.1 - 2.9e-50 171.4 1.2 1.1e-49 169.5 0.2 2.2 2 0 0 2 2 2 1 CPSF A subunit region TPX2 PF06886.11 EDO16317.1 - 2.3 8.5 6.5 6.7 7.0 6.5 1.8 1 0 0 1 1 1 0 Targeting protein for Xklp2 (TPX2) Myc_N PF01056.18 EDO16317.1 - 5.9 6.7 9.3 29 4.4 4.9 2.3 2 0 0 2 2 2 0 Myc amino-terminal region KCH PF16944.5 EDO16318.1 - 2.7e-95 318.9 23.9 2.7e-95 318.9 23.9 1.5 2 0 0 2 2 2 1 Fungal potassium channel Ly49 PF08391.10 EDO16319.1 - 0.044 14.1 0.7 0.044 14.1 0.7 3.1 2 1 0 3 3 3 0 Ly49-like protein, N-terminal region Sedlin_N PF04628.13 EDO16320.1 - 1.2e-13 51.3 1.4 1.5e-13 51.0 1.4 1.1 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region FAD_binding_2 PF00890.24 EDO16321.1 - 2.1e-69 234.6 0.0 2.4e-69 234.5 0.0 1.0 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 EDO16321.1 - 6.4e-08 32.2 2.7 9.9e-06 25.0 1.2 2.6 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EDO16321.1 - 2.4e-07 30.7 0.1 7.9e-05 22.4 0.0 2.3 1 1 0 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EDO16321.1 - 1e-05 25.7 0.0 2.7e-05 24.3 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 EDO16321.1 - 0.00011 21.6 0.7 0.015 14.6 0.0 2.3 2 0 0 2 2 2 2 Thi4 family Lycopene_cycl PF05834.12 EDO16321.1 - 0.0023 17.0 0.0 1.4 7.9 0.0 2.3 2 0 0 2 2 2 2 Lycopene cyclase protein MCRA PF06100.11 EDO16321.1 - 0.0038 16.1 0.2 0.31 9.8 0.0 2.1 2 0 0 2 2 2 2 MCRA family FAD_oxidored PF12831.7 EDO16321.1 - 0.0041 16.5 0.3 0.012 14.9 0.3 1.7 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 EDO16321.1 - 0.041 13.9 0.6 1.1 9.3 0.6 2.6 1 1 0 1 1 1 0 FAD-NAD(P)-binding FAD_binding_3 PF01494.19 EDO16321.1 - 0.098 11.9 0.9 0.13 11.4 0.2 1.6 2 0 0 2 2 2 0 FAD binding domain HI0933_like PF03486.14 EDO16321.1 - 0.31 9.7 4.3 0.98 8.0 0.8 2.6 2 1 0 2 2 2 0 HI0933-like protein GIDA PF01134.22 EDO16321.1 - 3.3 6.7 5.5 0.89 8.6 1.0 2.3 3 1 0 3 3 3 0 Glucose inhibited division protein A Beta_elim_lyase PF01212.21 EDO16322.1 - 8.2e-77 258.3 0.0 1e-76 258.1 0.0 1.1 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_1_2 PF00155.21 EDO16322.1 - 0.00036 19.8 0.0 0.00046 19.5 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II YL1_C PF08265.11 EDO16323.1 - 1.8e-12 46.8 0.2 3.6e-12 45.8 0.2 1.5 1 0 0 1 1 1 1 YL1 nuclear protein C-terminal domain Nramp PF01566.18 EDO16324.1 - 1.4e-87 294.0 12.8 4.4e-49 167.4 4.1 2.2 2 0 0 2 2 2 2 Natural resistance-associated macrophage protein fn3 PF00041.21 EDO16325.1 - 0.013 15.8 2.6 4.1 7.8 1.3 3.0 2 0 0 2 2 2 0 Fibronectin type III domain Phage_lysis PF03245.13 EDO16325.1 - 1.1 9.4 4.8 0.53 10.4 1.5 2.3 2 0 0 2 2 2 0 Bacteriophage Rz lysis protein Med9 PF07544.13 EDO16325.1 - 1.5 8.9 11.5 2.5 8.3 7.1 3.2 1 1 1 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 FAP206 PF12018.8 EDO16325.1 - 1.9 7.9 13.8 0.082 12.4 7.0 2.2 2 0 0 2 2 2 0 Domain of unknown function GDA1_CD39 PF01150.17 EDO16326.1 - 1.9e-117 392.5 0.0 2.3e-117 392.3 0.0 1.0 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family NAD_kinase PF01513.21 EDO16327.1 - 3.6e-88 295.5 0.0 4.6e-88 295.2 0.0 1.1 1 0 0 1 1 1 1 ATP-NAD kinase DAGK_cat PF00781.24 EDO16327.1 - 0.019 14.6 0.0 0.046 13.3 0.0 1.6 1 0 0 1 1 1 0 Diacylglycerol kinase catalytic domain Glyco_hydro_16 PF00722.21 EDO16328.1 - 1.5e-44 151.6 6.7 3.6e-44 150.3 6.7 1.6 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 ATP_synth_reg PF14960.6 EDO16328.1 - 0.53 9.8 2.3 5.4 6.6 0.2 2.4 2 0 0 2 2 2 0 ATP synthase regulation Chitin_bind_1 PF00187.19 EDO16328.1 - 2.4 8.7 11.3 5.6 7.5 11.3 1.6 1 0 0 1 1 1 0 Chitin recognition protein Cytochrom_C PF00034.21 EDO16329.1 - 7.2e-11 43.1 0.1 1.4e-10 42.2 0.1 1.4 1 1 0 1 1 1 1 Cytochrome c Cytochrome_CBB3 PF13442.6 EDO16329.1 - 3.4e-07 30.5 1.6 2.4e-06 27.8 1.6 1.9 1 1 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C550 PF14495.6 EDO16329.1 - 0.084 12.6 0.2 0.22 11.2 0.1 1.7 2 0 0 2 2 2 0 Cytochrome c-550 domain CCP_MauG PF03150.14 EDO16329.1 - 0.14 12.8 0.0 0.15 12.7 0.0 1.1 1 0 0 1 1 1 0 Di-haem cytochrome c peroxidase TusA PF01206.17 EDO16331.1 - 0.16 11.8 0.0 17 5.3 0.0 2.5 2 0 0 2 2 2 0 Sulfurtransferase TusA eIF-5a PF01287.20 EDO16332.1 - 1.7e-29 101.7 0.7 2.4e-29 101.2 0.7 1.2 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold EFP_N PF08207.12 EDO16332.1 - 0.00092 19.2 0.0 0.0014 18.6 0.0 1.3 1 0 0 1 1 1 1 Elongation factor P (EF-P) KOW-like domain NifU_N PF01592.16 EDO16333.1 - 1.4e-56 190.1 0.1 1.8e-56 189.8 0.1 1.1 1 0 0 1 1 1 1 NifU-like N terminal domain TSCPD PF12637.7 EDO16333.1 - 0.018 15.2 0.1 0.034 14.4 0.1 1.4 1 0 0 1 1 1 0 TSCPD domain RNA_pol_Rpb8 PF03870.15 EDO16334.1 - 8.3e-46 155.6 0.0 9.2e-46 155.5 0.0 1.0 1 0 0 1 1 1 1 RNA polymerase Rpb8 RNA_pol_RpbG PF16992.5 EDO16334.1 - 0.00051 20.1 0.4 0.3 11.1 0.1 2.0 2 0 0 2 2 2 2 DNA-directed RNA polymerase, subunit G TcpA PF05946.12 EDO16334.1 - 0.067 13.3 0.1 0.094 12.8 0.1 1.2 1 0 0 1 1 1 0 Toxin-coregulated pilus subunit TcpA DUF2407_C PF13373.6 EDO16335.1 - 1.2e-43 148.7 1.1 1.9e-43 148.0 1.1 1.3 1 0 0 1 1 1 1 DUF2407 C-terminal domain DUF2407 PF10302.9 EDO16335.1 - 6.1e-16 58.9 1.7 3.6e-14 53.2 1.7 2.4 1 1 0 1 1 1 1 DUF2407 ubiquitin-like domain Lant_dehydr_N PF04738.13 EDO16335.1 - 0.21 9.6 0.0 0.36 8.9 0.0 1.3 1 0 0 1 1 1 0 Lantibiotic dehydratase, N terminus Zn_clus PF00172.18 EDO16336.1 - 0.00015 21.8 8.5 0.00035 20.6 8.5 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CtaG_Cox11 PF04442.14 EDO16337.1 - 2.2e-60 203.0 0.0 3.6e-60 202.4 0.0 1.3 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein CtaG/Cox11 DUF733 PF05306.11 EDO16338.1 - 0.043 14.1 0.0 0.17 12.2 0.0 1.8 1 1 0 2 2 2 0 Protein of unknown function (DUF733) RFC1 PF08519.12 EDO16339.1 - 2.6e-58 196.6 1.0 7e-58 195.2 0.1 2.1 2 0 0 2 2 2 1 Replication factor RFC1 C terminal domain AAA PF00004.29 EDO16339.1 - 2.9e-13 50.4 0.1 1.2e-12 48.4 0.0 2.1 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) BRCT PF00533.26 EDO16339.1 - 7.7e-12 45.4 0.0 3.7e-11 43.3 0.0 2.3 2 0 0 2 2 1 1 BRCA1 C Terminus (BRCT) domain Rad17 PF03215.15 EDO16339.1 - 6.8e-06 26.1 0.0 2.2e-05 24.4 0.0 2.0 1 1 0 1 1 1 1 Rad17 P-loop domain RuvB_N PF05496.12 EDO16339.1 - 3e-05 23.8 0.5 7.2e-05 22.6 0.0 1.8 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EDO16339.1 - 0.0001 22.6 0.0 0.0004 20.7 0.0 2.0 1 0 0 1 1 1 1 AAA domain AAA_assoc_2 PF16193.5 EDO16339.1 - 0.0006 20.1 0.0 0.0021 18.4 0.0 1.9 1 0 0 1 1 1 1 AAA C-terminal domain AAA_16 PF13191.6 EDO16339.1 - 0.00063 20.2 0.0 0.0032 17.8 0.0 2.2 1 1 0 1 1 1 1 AAA ATPase domain AAA_18 PF13238.6 EDO16339.1 - 0.00092 19.8 0.0 0.0034 17.9 0.0 2.0 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EDO16339.1 - 0.0012 19.1 0.0 0.0036 17.5 0.0 1.8 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 EDO16339.1 - 0.0021 18.4 0.0 0.0073 16.7 0.0 2.1 1 1 0 1 1 1 1 RNA helicase AAA_17 PF13207.6 EDO16339.1 - 0.0029 18.0 4.5 0.0046 17.4 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_14 PF13173.6 EDO16339.1 - 0.0043 17.1 0.0 0.014 15.5 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.6 EDO16339.1 - 0.027 14.2 0.0 0.098 12.4 0.0 2.0 1 0 0 1 1 1 0 AAA domain PTCB-BRCT PF12738.7 EDO16339.1 - 0.047 13.7 0.0 0.16 12.0 0.0 2.0 1 0 0 1 1 1 0 twin BRCT domain Tfb2 PF03849.14 EDO16339.1 - 0.066 12.2 0.0 0.15 11.0 0.0 1.5 1 0 0 1 1 1 0 Transcription factor Tfb2 ANAPC4 PF12896.7 EDO16339.1 - 0.096 12.2 0.1 0.23 10.9 0.1 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 4 AAA_5 PF07728.14 EDO16339.1 - 0.11 12.4 0.0 0.27 11.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) NACHT PF05729.12 EDO16339.1 - 0.13 12.1 0.0 0.35 10.8 0.0 1.8 1 1 0 1 1 1 0 NACHT domain Spc7 PF08317.11 EDO16340.1 - 1.2e-07 31.0 54.6 0.00066 18.7 20.8 2.5 1 1 1 2 2 2 2 Spc7 kinetochore protein GRAB PF10375.9 EDO16340.1 - 2.5e-07 30.3 1.1 6.9e-07 28.9 1.1 1.8 1 0 0 1 1 1 1 GRIP-related Arf-binding domain Golgin_A5 PF09787.9 EDO16340.1 - 9.9e-07 28.5 55.2 0.0049 16.4 21.7 3.3 1 1 3 4 4 4 3 Golgin subfamily A member 5 APG6_N PF17675.1 EDO16340.1 - 1e-05 26.1 62.2 0.012 16.2 28.8 4.3 2 1 2 4 4 4 3 Apg6 coiled-coil region HIP1_clath_bdg PF16515.5 EDO16340.1 - 0.0049 17.4 61.4 0.2 12.3 6.9 6.2 2 2 4 6 6 6 3 Clathrin-binding domain of Huntingtin-interacting protein 1 PKcGMP_CC PF16808.5 EDO16340.1 - 0.0058 16.5 9.1 0.6 10.0 1.0 4.4 3 0 0 3 3 3 2 Coiled-coil N-terminus of cGMP-dependent protein kinase ATG16 PF08614.11 EDO16340.1 - 0.0063 16.8 18.9 0.0063 16.8 18.9 3.7 1 1 2 3 3 3 1 Autophagy protein 16 (ATG16) GAS PF13851.6 EDO16340.1 - 0.0081 15.5 61.5 0.037 13.4 25.7 4.2 1 1 3 4 4 4 2 Growth-arrest specific micro-tubule binding CENP-F_leu_zip PF10473.9 EDO16340.1 - 0.0085 16.1 27.2 0.0085 16.1 27.2 5.0 2 1 3 5 5 4 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 HsbA PF12296.8 EDO16340.1 - 0.0088 16.5 6.9 0.025 15.0 2.2 3.1 2 1 0 3 3 3 1 Hydrophobic surface binding protein A DUF1664 PF07889.12 EDO16340.1 - 0.012 15.7 5.3 0.012 15.7 5.3 4.4 2 2 2 4 4 4 0 Protein of unknown function (DUF1664) Lebercilin PF15619.6 EDO16340.1 - 0.017 14.8 60.6 1 9.0 32.1 4.0 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease TMF_DNA_bd PF12329.8 EDO16340.1 - 0.022 14.7 18.3 0.022 14.7 18.3 5.8 4 1 2 6 6 6 0 TATA element modulatory factor 1 DNA binding PRKG1_interact PF15898.5 EDO16340.1 - 0.034 15.1 13.7 0.034 15.1 13.7 4.9 1 1 2 3 3 3 0 cGMP-dependent protein kinase interacting domain LPD11 PF18824.1 EDO16340.1 - 0.037 14.1 4.0 0.047 13.8 0.9 2.7 2 0 0 2 2 2 0 Large polyvalent protein-associated domain 11 DUF1018 PF06252.12 EDO16340.1 - 0.038 15.0 1.0 0.038 15.0 1.0 3.2 2 1 0 3 3 2 0 Protein of unknown function (DUF1018) TMF_TATA_bd PF12325.8 EDO16340.1 - 0.053 13.7 53.9 0.2 11.9 15.3 4.3 1 1 2 3 3 3 0 TATA element modulatory factor 1 TATA binding BLOC1_2 PF10046.9 EDO16340.1 - 0.095 13.0 48.0 0.45 10.8 13.4 5.1 2 1 2 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Filament PF00038.21 EDO16340.1 - 0.1 12.2 49.8 0.72 9.4 22.3 2.9 1 1 1 2 2 2 0 Intermediate filament protein TACC_C PF05010.14 EDO16340.1 - 0.14 11.9 49.0 0.023 14.5 22.4 3.6 1 1 2 3 3 3 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal DUF2353 PF09789.9 EDO16340.1 - 0.21 10.9 49.5 0.025 13.9 15.4 3.0 2 1 1 3 3 3 0 Uncharacterized coiled-coil protein (DUF2353) DUF3584 PF12128.8 EDO16340.1 - 0.27 8.7 44.0 0.22 9.0 14.2 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) FPP PF05911.11 EDO16340.1 - 0.46 8.6 59.4 0.6 8.2 31.7 2.5 1 1 1 2 2 2 0 Filament-like plant protein, long coiled-coil DUF4407 PF14362.6 EDO16340.1 - 0.48 9.7 34.3 0.035 13.5 15.0 3.2 1 1 2 3 3 3 0 Domain of unknown function (DUF4407) TPR_MLP1_2 PF07926.12 EDO16340.1 - 0.57 10.3 58.4 0.096 12.8 23.8 4.7 1 1 2 4 4 4 0 TPR/MLP1/MLP2-like protein ADIP PF11559.8 EDO16340.1 - 0.96 9.5 52.7 0.44 10.6 16.8 4.4 1 1 3 4 4 4 0 Afadin- and alpha -actinin-Binding FUSC PF04632.12 EDO16340.1 - 1 7.8 5.6 3.2 6.2 4.8 1.8 1 1 1 2 2 2 0 Fusaric acid resistance protein family Laminin_II PF06009.12 EDO16340.1 - 1.8 8.6 42.9 1.1 9.3 10.9 4.6 1 1 3 4 4 4 0 Laminin Domain II Cnn_1N PF07989.11 EDO16340.1 - 2.2 8.5 51.9 3.7 7.8 6.8 6.6 1 1 3 4 4 4 0 Centrosomin N-terminal motif 1 HMMR_N PF15905.5 EDO16340.1 - 2.4 7.5 61.4 0.021 14.3 26.2 3.6 1 1 3 4 4 4 0 Hyaluronan mediated motility receptor N-terminal DUF4164 PF13747.6 EDO16340.1 - 2.6 8.4 34.4 0.45 10.8 5.6 4.9 1 1 3 5 5 5 0 Domain of unknown function (DUF4164) COMP PF11598.8 EDO16340.1 - 3.1 8.3 8.7 1.2 9.6 1.5 3.3 3 0 0 3 3 2 0 Cartilage oligomeric matrix protein DUF812 PF05667.11 EDO16340.1 - 6.3 5.6 53.1 2.7e+03 -3.1 50.9 3.0 1 1 0 1 1 1 0 Protein of unknown function (DUF812) KASH_CCD PF14662.6 EDO16340.1 - 8.5 6.2 61.8 4.3 7.1 27.0 3.8 1 1 2 4 4 4 0 Coiled-coil region of CCDC155 or KASH YqeY PF09424.10 EDO16341.1 - 4.4e-21 75.4 1.8 5.4e-21 75.2 1.8 1.1 1 0 0 1 1 1 1 Yqey-like protein CUTL PF16557.5 EDO16341.1 - 0.00035 20.7 0.3 0.027 14.7 0.1 2.5 2 0 0 2 2 2 1 CUT1-like DNA-binding domain of SATB MitMem_reg PF13012.6 EDO16341.1 - 0.012 16.0 0.2 0.016 15.6 0.2 1.4 1 0 0 1 1 1 0 Maintenance of mitochondrial structure and function PBP1_TM PF14812.6 EDO16342.1 - 0.042 14.2 0.8 0.042 14.2 0.8 2.0 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal NOA36 PF06524.12 EDO16342.1 - 9.1 5.5 7.5 15 4.8 7.5 1.2 1 0 0 1 1 1 0 NOA36 protein Asp PF00026.23 EDO16343.1 - 6.2e-23 81.7 0.1 1.5e-21 77.2 0.0 2.8 2 1 0 2 2 2 1 Eukaryotic aspartyl protease Sec23_trunk PF04811.15 EDO16344.1 - 6.6e-57 192.9 0.3 8.9e-57 192.4 0.3 1.2 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain zf-Sec23_Sec24 PF04810.15 EDO16344.1 - 3.2e-12 46.3 5.2 8e-12 45.0 5.2 1.8 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger VWA_2 PF13519.6 EDO16344.1 - 0.012 16.3 0.0 0.041 14.5 0.0 1.9 1 1 1 2 2 2 0 von Willebrand factor type A domain Sec23_helical PF04815.15 EDO16345.1 - 2.1e-22 78.9 0.5 4.3e-22 77.9 0.5 1.6 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Sec23_BS PF08033.12 EDO16345.1 - 6.6e-10 39.6 0.0 1.4e-09 38.6 0.0 1.6 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain Gelsolin PF00626.22 EDO16345.1 - 9.3e-05 22.3 0.0 0.00018 21.4 0.0 1.5 1 0 0 1 1 1 1 Gelsolin repeat Pal1 PF08316.11 EDO16346.1 - 2.3e-51 174.1 1.8 2.3e-51 174.1 1.8 3.5 3 1 0 3 3 3 1 Pal1 cell morphology protein TMEM174 PF15029.6 EDO16346.1 - 3 7.5 5.2 7.4 6.2 5.2 1.7 1 0 0 1 1 1 0 Transmembrane protein 174 RR_TM4-6 PF06459.12 EDO16346.1 - 9.6 5.9 8.6 29 4.3 8.6 1.8 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Sod_Fe_C PF02777.18 EDO16347.1 - 2.9e-12 46.7 0.2 4e-05 23.7 0.2 2.4 1 1 1 2 2 2 2 Iron/manganese superoxide dismutases, C-terminal domain Sugar_tr PF00083.24 EDO16348.1 - 9.7e-162 538.9 29.6 1.1e-161 538.7 29.6 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDO16348.1 - 6.7e-26 91.0 30.4 3.4e-22 78.9 18.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily tRNA-synt_1d PF00750.19 EDO16349.1 - 1.6e-123 412.1 5.9 2.1e-123 411.7 5.9 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (R) DALR_1 PF05746.15 EDO16349.1 - 1.6e-29 102.5 2.4 5.7e-29 100.7 0.2 2.6 3 0 0 3 3 3 1 DALR anticodon binding domain Arg_tRNA_synt_N PF03485.16 EDO16349.1 - 2.7e-10 40.7 0.0 9e-10 39.0 0.0 2.0 1 0 0 1 1 1 1 Arginyl tRNA synthetase N terminal domain Clat_adaptor_s PF01217.20 EDO16350.1 - 9.7e-56 187.7 1.6 1.2e-55 187.4 1.6 1.1 1 0 0 1 1 1 1 Clathrin adaptor complex small chain SPO22 PF08631.10 EDO16350.1 - 0.079 12.4 0.1 0.11 11.9 0.1 1.4 1 1 0 1 1 1 0 Meiosis protein SPO22/ZIP4 like zf-RRN7 PF11781.8 EDO16351.1 - 8.6e-10 38.1 0.6 1.6e-09 37.2 0.6 1.5 1 0 0 1 1 1 1 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 SpoVIF PF14069.6 EDO16352.1 - 0.018 14.8 6.1 0.15 11.9 0.1 3.0 2 1 1 3 3 3 0 Stage VI sporulation protein F FixH PF05751.11 EDO16352.1 - 0.12 12.3 0.1 0.17 11.9 0.1 1.2 1 0 0 1 1 1 0 FixH DUF2838 PF10998.8 EDO16353.1 - 3.3e-41 140.0 15.3 3.3e-41 140.0 15.3 2.7 3 0 0 3 3 3 1 Protein of unknown function (DUF2838) DivIC PF04977.15 EDO16353.1 - 0.0049 16.6 0.5 0.015 15.1 0.5 1.8 1 0 0 1 1 1 1 Septum formation initiator Fungal_TACC PF12709.7 EDO16353.1 - 0.066 13.7 3.0 0.15 12.5 3.0 1.5 1 0 0 1 1 1 0 Fungal Transforming acidic coiled-coil (TACC) proteins PPR_2 PF13041.6 EDO16354.1 - 4.9e-15 55.5 0.4 1.9e-09 37.5 0.1 2.9 2 0 0 2 2 2 2 PPR repeat family PPR PF01535.20 EDO16354.1 - 1e-07 31.7 0.4 3.1e-05 23.9 0.0 3.0 2 0 0 2 2 2 1 PPR repeat PPR_long PF17177.4 EDO16354.1 - 2.4e-07 30.4 0.0 0.00029 20.3 0.0 2.5 1 1 1 2 2 2 2 Pentacotripeptide-repeat region of PRORP PPR_3 PF13812.6 EDO16354.1 - 5.1e-07 29.7 0.0 0.0016 18.5 0.0 3.0 1 1 1 2 2 2 2 Pentatricopeptide repeat domain DUF4375 PF14300.6 EDO16354.1 - 7.4 6.9 7.4 15 5.9 0.0 3.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4375) Cgr1 PF03879.14 EDO16355.1 - 8.2e-34 116.2 31.9 9.5e-34 116.0 31.9 1.0 1 0 0 1 1 1 1 Cgr1 family DUF2048 PF09752.9 EDO16355.1 - 0.028 13.5 4.3 0.032 13.3 4.3 1.1 1 0 0 1 1 1 0 Abhydrolase domain containing 18 UPF0242 PF06785.11 EDO16355.1 - 2.1 8.4 14.6 2.7 8.0 14.6 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus HIM1 PF08732.10 EDO16356.1 - 5.3e-59 198.5 2.2 8.4e-59 197.9 2.2 1.3 1 0 0 1 1 1 1 HIM1 CENP-O PF09496.10 EDO16357.1 - 2.9e-12 47.0 0.1 2.9e-12 47.0 0.1 2.5 2 2 0 2 2 2 1 Cenp-O kinetochore centromere component DivIC PF04977.15 EDO16357.1 - 0.035 13.9 1.2 0.13 12.1 1.2 2.0 1 0 0 1 1 1 0 Septum formation initiator DUF4349 PF14257.6 EDO16357.1 - 0.047 13.1 0.5 0.085 12.3 0.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4349) Nop10p PF04135.12 EDO16358.1 - 4.6e-22 77.8 0.3 5.1e-22 77.7 0.3 1.0 1 0 0 1 1 1 1 Nucleolar RNA-binding protein, Nop10p family Asparaginase PF00710.20 EDO16359.1 - 1.2e-55 188.0 0.0 1.9e-55 187.4 0.0 1.3 1 0 0 1 1 1 1 Asparaginase, N-terminal Asparaginase_C PF17763.1 EDO16359.1 - 1.6e-17 63.7 0.0 3.1e-17 62.8 0.0 1.5 1 0 0 1 1 1 1 Glutaminase/Asparaginase C-terminal domain Ribosomal_L19 PF01245.20 EDO16359.1 - 0.035 14.1 0.0 8.2 6.4 0.0 3.0 3 0 0 3 3 3 0 Ribosomal protein L19 FAD_binding_1 PF00667.20 EDO16360.1 - 5.9e-73 245.1 0.0 8.5e-73 244.6 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 EDO16360.1 - 9.7e-29 100.4 0.4 1.8e-28 99.6 0.4 1.5 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.21 EDO16360.1 - 1.6e-21 77.0 0.0 3.5e-21 75.9 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain HAD_2 PF13419.6 EDO16361.1 - 1.8e-15 57.5 0.0 3e-15 56.7 0.0 1.4 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EDO16361.1 - 8.7e-06 26.2 0.0 0.00026 21.3 0.0 2.3 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EDO16361.1 - 0.014 15.4 0.1 0.025 14.6 0.1 1.4 1 0 0 1 1 1 0 HAD-hyrolase-like HAD PF12710.7 EDO16361.1 - 0.026 14.9 0.0 0.042 14.2 0.0 1.3 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase RNase_PH PF01138.21 EDO16362.1 - 6.5e-21 75.2 0.0 1.1e-20 74.5 0.0 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 EDO16362.1 - 4.1e-17 62.0 0.3 8.3e-17 61.0 0.1 1.7 2 0 0 2 2 2 1 3' exoribonuclease family, domain 2 RNase_H2-Ydr279 PF09468.10 EDO16363.1 - 1.1e-18 68.0 0.8 1.1e-18 68.0 0.8 1.7 2 0 0 2 2 2 1 Ydr279p protein family (RNase H2 complex component) wHTH domain Ydr279_N PF17745.1 EDO16363.1 - 1.9e-11 44.0 0.3 6.1e-11 42.4 0.1 1.9 2 0 0 2 2 2 1 Ydr279p protein triple barrel domain MqsR_toxin PF15723.5 EDO16363.1 - 0.062 13.7 0.1 0.22 11.9 0.1 1.9 1 0 0 1 1 1 0 Motility quorum-sensing regulator, toxin of MqsA Inositol_P PF00459.25 EDO16365.1 - 3.7e-64 216.9 0.0 4.1e-64 216.7 0.0 1.0 1 0 0 1 1 1 1 Inositol monophosphatase family MFS_1 PF07690.16 EDO16366.1 - 1.5e-38 132.7 30.5 1.5e-38 132.7 30.5 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EDO16366.1 - 1.5e-05 24.1 20.5 1.5e-05 24.1 20.5 3.1 2 1 1 3 3 3 1 Sugar (and other) transporter DUF2254 PF10011.9 EDO16366.1 - 0.92 8.3 4.4 1.2 7.9 0.1 2.6 3 0 0 3 3 3 0 Predicted membrane protein (DUF2254) FSH1 PF03959.13 EDO16367.1 - 3.7e-65 219.6 0.0 4.1e-65 219.4 0.0 1.0 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_2 PF02230.16 EDO16367.1 - 0.00018 21.4 0.2 0.13 12.1 0.1 2.6 2 1 0 2 2 2 2 Phospholipase/Carboxylesterase Nramp PF01566.18 EDO16368.1 - 6.9e-94 314.8 11.3 1.3e-93 313.9 11.3 1.4 1 1 0 1 1 1 1 Natural resistance-associated macrophage protein ESSS PF10183.9 EDO16368.1 - 0.6 10.4 0.0 0.6 10.4 0.0 2.3 3 0 0 3 3 3 0 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) COX5A PF02284.16 EDO16369.1 - 7e-38 128.8 1.8 9.6e-38 128.3 1.8 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase subunit Va PAF-AH_p_II PF03403.13 EDO16369.1 - 0.088 11.3 0.1 0.13 10.8 0.1 1.2 1 0 0 1 1 1 0 Platelet-activating factor acetylhydrolase, isoform II Ribosomal_S4 PF00163.19 EDO16369.1 - 0.19 12.7 0.7 0.87 10.6 0.0 2.1 2 1 0 2 2 2 0 Ribosomal protein S4/S9 N-terminal domain Elf1 PF05129.13 EDO16370.1 - 1.3e-30 105.3 2.3 1.6e-30 104.9 2.3 1.1 1 0 0 1 1 1 1 Transcription elongation factor Elf1 like IMUP PF15761.5 EDO16370.1 - 0.017 15.8 1.6 0.029 15.1 1.6 1.4 1 0 0 1 1 1 0 Immortalisation up-regulated protein Ribosomal_L37ae PF01780.19 EDO16370.1 - 0.15 12.2 1.2 0.25 11.4 1.2 1.3 1 0 0 1 1 1 0 Ribosomal L37ae protein family Ribosomal_L1 PF00687.21 EDO16371.1 - 5.8e-39 133.9 5.2 9.2e-39 133.3 5.2 1.3 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family MatE PF01554.18 EDO16372.1 - 4.6e-66 221.4 34.7 2.9e-38 131.0 9.7 2.6 3 0 0 3 3 3 2 MatE PhzC-PhzF PF02567.16 EDO16373.1 - 6.3e-63 212.9 0.0 7e-63 212.7 0.0 1.0 1 0 0 1 1 1 1 Phenazine biosynthesis-like protein Pro_racemase PF05544.11 EDO16373.1 - 0.031 13.3 0.0 0.47 9.4 0.0 2.1 2 0 0 2 2 2 0 Proline racemase DAP_epimerase PF01678.19 EDO16373.1 - 0.15 12.2 0.0 9.5 6.4 0.0 2.5 2 1 0 2 2 2 0 Diaminopimelate epimerase DPPIV_N PF00930.21 EDO16374.1 - 1.5e-99 333.1 4.9 2.4e-99 332.5 4.9 1.3 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.21 EDO16374.1 - 2.6e-54 183.9 1.1 4.5e-54 183.1 1.1 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_6 PF12697.7 EDO16374.1 - 3e-05 24.7 0.0 0.0026 18.4 0.0 2.3 1 1 1 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EDO16374.1 - 0.0081 15.8 0.3 0.026 14.2 0.3 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_2 PF02230.16 EDO16374.1 - 0.069 12.9 0.1 11 5.7 0.0 2.5 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase DLH PF01738.18 EDO16374.1 - 0.091 12.3 0.0 0.46 10.0 0.0 2.0 1 1 0 1 1 1 0 Dienelactone hydrolase family Abhydrolase_3 PF07859.13 EDO16374.1 - 0.13 12.1 0.0 0.23 11.3 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold RPN1_RPN2_N PF17781.1 EDO16375.1 - 1.9e-111 372.4 0.9 3.5e-111 371.5 0.9 1.4 1 0 0 1 1 1 1 RPN1/RPN2 N-terminal domain RPN1_C PF18051.1 EDO16375.1 - 3.2e-29 100.7 0.1 6.8e-29 99.7 0.1 1.6 1 0 0 1 1 1 1 26S proteasome non-ATPase regulatory subunit RPN1 C-terminal PC_rep PF01851.22 EDO16375.1 - 2.2e-23 81.4 26.6 1.6e-07 31.4 0.1 9.8 11 0 0 11 11 11 5 Proteasome/cyclosome repeat HEAT_2 PF13646.6 EDO16375.1 - 0.00025 21.4 0.0 1.9 8.9 0.0 4.1 4 1 1 5 5 5 2 HEAT repeats Myosin_head PF00063.21 EDO16376.1 - 1.2e-237 790.5 30.2 1.2e-237 790.5 30.2 4.0 4 1 0 5 5 5 1 Myosin head (motor domain) AAA_16 PF13191.6 EDO16376.1 - 0.027 14.8 0.0 0.32 11.4 0.0 2.9 1 0 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 EDO16376.1 - 0.26 11.6 0.0 0.26 11.6 0.0 4.1 4 0 0 4 4 4 0 AAA domain Pox_A_type_inc PF04508.12 EDO16376.1 - 8.9 6.4 8.0 61 3.7 0.1 4.5 3 0 0 3 3 3 0 Viral A-type inclusion protein repeat Ras PF00071.22 EDO16377.1 - 7.7e-09 35.4 0.7 5.3e-05 22.9 0.2 2.5 2 0 0 2 2 2 2 Ras family SRPRB PF09439.10 EDO16377.1 - 0.00011 21.7 0.3 0.022 14.2 0.0 2.3 1 1 0 2 2 2 2 Signal recognition particle receptor beta subunit Roc PF08477.13 EDO16377.1 - 0.0027 17.9 0.1 0.035 14.3 0.0 2.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase AAA_16 PF13191.6 EDO16377.1 - 0.035 14.5 0.0 0.059 13.8 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain MMR_HSR1 PF01926.23 EDO16377.1 - 0.089 12.9 0.1 0.18 11.9 0.1 1.7 1 1 0 1 1 1 0 50S ribosome-binding GTPase ANAPC1 PF12859.7 EDO16379.1 - 9.3e-06 26.2 0.3 3.6e-05 24.3 0.3 2.2 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 1 PC_rep PF01851.22 EDO16379.1 - 0.23 12.0 6.8 49 4.6 0.3 5.2 5 0 0 5 5 5 0 Proteasome/cyclosome repeat PS_Dcarbxylase PF02666.15 EDO16380.1 - 9.8e-69 230.9 0.0 1.5e-68 230.3 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase dCMP_cyt_deam_1 PF00383.23 EDO16381.1 - 1.8e-27 95.1 1.4 2.6e-27 94.6 1.4 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 EDO16381.1 - 6.2e-16 58.4 0.7 1.5e-15 57.1 0.1 1.8 2 0 0 2 2 2 1 MafB19-like deaminase APOBEC4_like PF18774.1 EDO16381.1 - 0.029 14.3 0.1 0.062 13.2 0.1 1.5 1 0 0 1 1 1 0 APOBEC4-like -AID/APOBEC-deaminase TPPII PF12580.8 EDO16381.1 - 0.034 13.6 0.3 0.058 12.9 0.3 1.3 1 0 0 1 1 1 0 Tripeptidyl peptidase II Rep_fac_C PF08542.11 EDO16381.1 - 0.058 13.8 0.1 0.13 12.7 0.1 1.5 1 0 0 1 1 1 0 Replication factor C C-terminal domain SNAD4 PF18750.1 EDO16381.1 - 0.14 12.3 0.4 0.31 11.2 0.4 1.6 1 0 0 1 1 1 0 Secreted Novel AID/APOBEC-like Deaminase 4 FAA_hydrolase PF01557.18 EDO16382.1 - 1.6e-46 158.7 0.0 2e-46 158.4 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family DNA_RNApol_7kD PF03604.13 EDO16383.1 - 1e-16 60.2 1.7 1.4e-16 59.9 1.7 1.2 1 0 0 1 1 1 1 DNA directed RNA polymerase, 7 kDa subunit zf_UBZ PF18439.1 EDO16383.1 - 0.004 16.7 0.8 1.5 8.5 0.1 2.2 2 0 0 2 2 2 2 Ubiquitin-Binding Zinc Finger DZR PF12773.7 EDO16383.1 - 0.0065 16.5 0.4 0.0089 16.0 0.4 1.3 1 0 0 1 1 1 1 Double zinc ribbon TFIIS_C PF01096.18 EDO16383.1 - 0.011 15.6 0.7 3.9 7.4 0.1 2.3 2 0 0 2 2 2 0 Transcription factor S-II (TFIIS) HypA PF01155.19 EDO16383.1 - 0.014 15.4 0.2 0.015 15.3 0.2 1.1 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zinc-ribbons_6 PF07191.12 EDO16383.1 - 0.019 14.9 0.4 0.025 14.6 0.4 1.3 1 0 0 1 1 1 0 zinc-ribbons MCM_OB PF17207.3 EDO16383.1 - 0.028 14.3 0.2 0.03 14.2 0.2 1.1 1 0 0 1 1 1 0 MCM OB domain zinc_ribbon_10 PF10058.9 EDO16383.1 - 0.064 13.0 0.2 0.62 9.8 0.0 2.0 2 0 0 2 2 2 0 Predicted integral membrane zinc-ribbon metal-binding protein Ribosomal_L40e PF01020.17 EDO16383.1 - 0.067 13.1 2.2 0.094 12.6 2.2 1.3 1 0 0 1 1 1 0 Ribosomal L40e family DUF2197 PF09963.9 EDO16383.1 - 0.073 13.3 1.9 5.5 7.3 0.1 2.2 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2197) Zn_ribbon_SprT PF17283.2 EDO16383.1 - 0.092 12.7 2.3 0.14 12.1 1.7 1.6 1 1 2 3 3 3 0 SprT-like zinc ribbon domain DUF4428 PF14471.6 EDO16383.1 - 0.095 12.6 1.5 1.5 8.8 0.1 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4428) FYDLN_acid PF09538.10 EDO16383.1 - 0.13 13.0 0.2 0.14 12.9 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) Zn-ribbon_8 PF09723.10 EDO16383.1 - 0.22 11.6 3.2 0.81 9.9 3.1 1.9 1 1 2 3 3 3 0 Zinc ribbon domain Zn_ribbon_recom PF13408.6 EDO16383.1 - 0.26 11.9 2.9 3.7 8.1 0.6 2.1 1 1 1 2 2 2 0 Recombinase zinc beta ribbon domain Rubredoxin_2 PF18073.1 EDO16383.1 - 0.52 10.1 2.7 9.7 6.0 0.3 2.2 2 0 0 2 2 2 0 Rubredoxin metal binding domain Ribosomal_L44 PF00935.19 EDO16383.1 - 1.4 9.4 5.0 13 6.3 0.7 2.1 1 1 1 2 2 2 0 Ribosomal protein L44 Molydop_binding PF01568.21 EDO16386.1 - 0.0071 16.4 0.3 0.018 15.1 0.3 1.6 1 0 0 1 1 1 1 Molydopterin dinucleotide binding domain GTP_EFTU PF00009.27 EDO16388.1 - 1.2e-58 197.9 0.0 2.6e-58 196.8 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_C PF00679.24 EDO16388.1 - 6.7e-14 51.7 0.0 2.6e-13 49.8 0.0 2.1 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 EDO16388.1 - 8.6e-10 38.9 0.0 3.5e-09 36.9 0.0 2.0 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_II PF14492.6 EDO16388.1 - 1.3e-08 34.8 0.0 3.1e-08 33.6 0.0 1.6 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_IV PF03764.18 EDO16388.1 - 0.00031 20.5 0.0 0.00091 19.0 0.0 1.8 1 0 0 1 1 1 1 Elongation factor G, domain IV MMR_HSR1 PF01926.23 EDO16388.1 - 0.0065 16.5 0.0 0.021 14.9 0.0 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase TFB6 PF17110.5 EDO16388.1 - 0.54 10.0 7.1 1.4 8.6 7.1 1.7 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH TRAP_alpha PF03896.16 EDO16388.1 - 2.2 7.4 8.6 4.9 6.3 8.6 1.5 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit RPN2_C PF18004.1 EDO16388.1 - 4.2 7.3 9.9 0.24 11.3 2.8 2.3 2 0 0 2 2 2 0 26S proteasome regulatory subunit RPN2 C-terminal domain IBR PF01485.21 EDO16389.1 - 0.032 14.5 4.8 0.057 13.7 0.8 2.1 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain Chs7 PF12271.8 EDO16390.1 - 1.5e-113 378.9 19.8 1.7e-113 378.7 19.8 1.0 1 0 0 1 1 1 1 Chitin synthase export chaperone IncD PF17628.2 EDO16390.1 - 1.8 8.3 5.0 5.9 6.7 3.1 2.3 2 0 0 2 2 2 0 Inclusion membrane protein D Ribosomal_L44 PF00935.19 EDO16391.1 - 7.1e-36 122.5 11.5 1.1e-35 122.0 11.5 1.3 1 0 0 1 1 1 1 Ribosomal protein L44 Far-17a_AIG1 PF04750.14 EDO16392.1 - 5.8e-15 55.1 7.1 7.4e-15 54.8 7.1 1.1 1 0 0 1 1 1 1 FAR-17a/AIG1-like protein SIR2 PF02146.17 EDO16393.1 - 1.1e-28 100.3 0.0 2e-28 99.5 0.0 1.4 1 1 0 1 1 1 1 Sir2 family TIP49 PF06068.13 EDO16394.1 - 2.6e-169 563.0 0.4 3.2e-169 562.7 0.4 1.1 1 0 0 1 1 1 1 TIP49 P-loop domain TIP49_C PF17856.1 EDO16394.1 - 7.8e-22 77.2 0.3 2e-21 75.9 0.3 1.8 1 0 0 1 1 1 1 TIP49 AAA-lid domain AAA PF00004.29 EDO16394.1 - 1.5e-08 35.1 0.3 8.5e-05 23.0 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 EDO16394.1 - 1.8e-07 31.0 0.5 7.3e-05 22.6 0.0 2.6 3 0 0 3 3 3 2 Holliday junction DNA helicase RuvB P-loop domain AAA_28 PF13521.6 EDO16394.1 - 0.0012 19.1 0.0 0.0025 18.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EDO16394.1 - 0.0029 17.9 0.9 3 8.2 0.0 2.5 2 0 0 2 2 2 2 AAA domain DnaB_C PF03796.15 EDO16394.1 - 0.014 14.7 0.0 0.03 13.6 0.0 1.5 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain Mg_chelatase PF01078.21 EDO16394.1 - 0.02 14.3 0.1 4 6.8 0.0 2.3 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_16 PF13191.6 EDO16394.1 - 0.031 14.6 0.1 0.15 12.5 0.1 2.2 1 1 0 1 1 1 0 AAA ATPase domain AAA_5 PF07728.14 EDO16394.1 - 0.041 13.9 0.5 1.4 8.9 0.0 2.6 3 0 0 3 3 2 0 AAA domain (dynein-related subfamily) CPT PF07931.12 EDO16394.1 - 0.044 13.6 0.0 0.11 12.4 0.0 1.7 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein Zeta_toxin PF06414.12 EDO16394.1 - 0.054 12.8 0.1 0.18 11.1 0.1 1.8 2 0 0 2 2 2 0 Zeta toxin Sigma54_activat PF00158.26 EDO16394.1 - 0.13 12.0 0.0 14 5.3 0.0 2.5 2 0 0 2 2 2 0 Sigma-54 interaction domain Sec1 PF00995.23 EDO16395.1 - 1.1e-121 408.0 9.5 1.2e-121 407.8 9.5 1.0 1 0 0 1 1 1 1 Sec1 family ubiquitin PF00240.23 EDO16397.1 - 1.6e-34 117.5 0.5 3e-34 116.6 0.5 1.5 1 0 0 1 1 1 1 Ubiquitin family Ribosomal_S27 PF01599.19 EDO16397.1 - 8.9e-24 83.4 2.6 8.9e-24 83.4 2.6 1.8 2 0 0 2 2 2 1 Ribosomal protein S27a Rad60-SLD PF11976.8 EDO16397.1 - 7.1e-16 57.8 0.6 7.1e-16 57.8 0.6 1.9 2 1 1 3 3 3 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EDO16397.1 - 2.4e-05 24.7 0.3 0.00013 22.4 0.1 2.2 2 1 0 2 2 2 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 EDO16397.1 - 0.00093 19.3 0.5 0.0023 18.0 0.5 1.7 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_5 PF18037.1 EDO16397.1 - 0.0058 17.0 0.7 0.012 16.0 0.0 1.7 1 1 1 2 2 2 1 Ubiquitin-like domain TBK1_ULD PF18396.1 EDO16397.1 - 0.0063 16.4 0.0 0.0099 15.8 0.0 1.3 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain DUF2407 PF10302.9 EDO16397.1 - 0.013 16.0 0.6 0.018 15.6 0.6 1.3 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain Ubiquitin_4 PF18036.1 EDO16397.1 - 0.016 15.2 1.1 5.4 7.1 0.2 2.5 2 0 0 2 2 2 0 Ubiquitin-like domain Metallophos PF00149.28 EDO16398.1 - 4.1e-13 50.3 2.1 6.1e-13 49.7 2.1 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Nipped-B_C PF12830.7 EDO16399.1 - 1.3e-40 139.4 1.0 1.3e-40 139.4 1.0 3.6 4 0 0 4 4 4 1 Sister chromatid cohesion C-terminus Cohesin_HEAT PF12765.7 EDO16399.1 - 1.7e-14 53.8 4.3 1.4e-13 50.9 3.0 2.9 2 0 0 2 2 2 1 HEAT repeat associated with sister chromatid cohesion HEAT PF02985.22 EDO16399.1 - 2.8e-05 24.0 0.4 4.8 7.7 0.0 5.9 5 0 0 5 5 5 1 HEAT repeat IBN_N PF03810.19 EDO16399.1 - 0.093 12.7 0.9 4.9 7.2 0.3 4.0 3 0 0 3 3 3 0 Importin-beta N-terminal domain DUF4670 PF15709.5 EDO16399.1 - 0.23 10.7 0.1 0.39 10.0 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4670) PseudoU_synth_2 PF00849.22 EDO16400.1 - 1.3e-17 64.4 0.0 6.4e-16 58.9 0.0 2.2 1 1 0 1 1 1 1 RNA pseudouridylate synthase PXA PF02194.15 EDO16401.1 - 1e-13 51.7 7.6 2.9e-12 46.9 3.2 3.2 2 1 0 2 2 2 2 PXA domain UQ_con PF00179.26 EDO16402.1 - 2.7e-44 150.2 0.1 4.1e-44 149.6 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UBA_3 PF09288.10 EDO16402.1 - 2e-25 88.3 0.6 3.3e-25 87.6 0.6 1.4 1 0 0 1 1 1 1 Fungal ubiquitin-associated domain Calsarcin PF05556.11 EDO16402.1 - 0.0059 16.2 0.0 0.01 15.4 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-binding protein (Calsarcin) Ada3 PF10198.9 EDO16403.1 - 7e-43 145.9 1.1 1.6e-42 144.8 1.1 1.6 1 0 0 1 1 1 1 Histone acetyltransferases subunit 3 DinB PF05163.12 EDO16404.1 - 0.0043 17.0 1.5 0.0056 16.6 1.5 1.1 1 0 0 1 1 1 1 DinB family RP-C_C PF11800.8 EDO16404.1 - 0.1 12.7 9.4 0.13 12.3 9.4 1.2 1 0 0 1 1 1 0 Replication protein C C-terminal region Polyoma_coat2 PF00761.20 EDO16404.1 - 0.83 9.3 2.6 0.94 9.1 1.7 1.5 1 1 1 2 2 2 0 Polyomavirus coat protein FancD2 PF14631.6 EDO16404.1 - 0.91 6.8 8.6 1.1 6.6 8.6 1.0 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease ALMT PF11744.8 EDO16404.1 - 1.1 8.0 8.3 1.4 7.7 8.3 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter V_ATPase_I PF01496.19 EDO16404.1 - 6.4 4.6 9.1 7 4.4 9.1 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family MRP-S28 PF10213.9 EDO16405.1 - 1.9e-50 170.5 4.2 3.8e-50 169.5 4.2 1.5 1 0 0 1 1 1 1 Mitochondrial ribosomal subunit protein PfkB PF00294.24 EDO16406.1 - 2.6e-07 30.3 0.0 3.9e-07 29.7 0.0 1.2 1 0 0 1 1 1 1 pfkB family carbohydrate kinase TENA_THI-4 PF03070.16 EDO16407.1 - 5.3e-09 36.2 2.9 8e-09 35.6 2.9 1.3 1 0 0 1 1 1 1 TENA/THI-4/PQQC family LCD1 PF09798.9 EDO16407.1 - 0.045 12.3 0.4 0.064 11.8 0.4 1.1 1 0 0 1 1 1 0 DNA damage checkpoint protein LSM PF01423.22 EDO16408.1 - 3.3e-09 36.3 0.2 4.7e-09 35.8 0.2 1.3 1 0 0 1 1 1 1 LSM domain DUF4976 PF16347.5 EDO16409.1 - 0.0012 19.0 0.4 0.0013 19.0 0.4 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4976) DUF2026 PF09641.10 EDO16409.1 - 0.014 15.1 0.1 0.017 14.8 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2026) UQ_con PF00179.26 EDO16410.1 - 8.7e-40 135.6 0.1 1.2e-39 135.2 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Epimerase PF01370.21 EDO16411.1 - 3.5e-18 65.9 0.1 4.5e-18 65.6 0.1 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EDO16411.1 - 9.7e-17 60.9 0.2 1.3e-16 60.5 0.2 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 EDO16411.1 - 6.8e-12 45.4 0.5 1.2e-11 44.6 0.5 1.7 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 EDO16411.1 - 3.7e-10 39.4 0.4 9.4e-09 34.8 0.4 2.1 1 1 0 1 1 1 1 Male sterility protein NAD_binding_10 PF13460.6 EDO16411.1 - 1.3e-07 31.7 0.0 3.8e-07 30.2 0.0 1.8 2 0 0 2 2 2 1 NAD(P)H-binding KR PF08659.10 EDO16411.1 - 2.2e-06 27.7 0.0 3.6e-06 27.0 0.0 1.4 1 0 0 1 1 1 1 KR domain NmrA PF05368.13 EDO16411.1 - 1.1e-05 25.1 0.0 0.00042 19.9 0.0 2.2 2 0 0 2 2 2 1 NmrA-like family adh_short PF00106.25 EDO16411.1 - 1.2e-05 24.8 0.2 3.2e-05 23.5 0.0 1.9 2 0 0 2 2 2 1 short chain dehydrogenase Polysacc_synt_2 PF02719.15 EDO16411.1 - 3.5e-05 23.1 0.5 6e-05 22.3 0.5 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 EDO16411.1 - 0.0045 16.1 0.0 0.0085 15.2 0.0 1.5 1 0 0 1 1 1 1 RmlD substrate binding domain Semialdhyde_dh PF01118.24 EDO16411.1 - 0.031 14.7 0.0 0.082 13.3 0.0 1.7 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain Shikimate_DH PF01488.20 EDO16411.1 - 0.094 12.8 0.6 0.4 10.7 0.2 2.1 1 1 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase LRR_6 PF13516.6 EDO16412.1 - 2e-08 33.7 14.2 1.2 9.4 0.0 7.4 8 0 0 8 8 8 5 Leucine Rich repeat LRR_4 PF12799.7 EDO16412.1 - 5.5e-08 33.0 20.9 0.037 14.5 0.4 7.1 4 2 3 8 8 8 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EDO16412.1 - 6.1e-07 29.1 6.2 6.1 7.8 0.1 6.4 6 0 0 6 6 6 2 Leucine Rich Repeat LRR_8 PF13855.6 EDO16412.1 - 0.002 17.9 18.9 0.34 10.7 0.2 6.1 6 1 0 6 6 6 2 Leucine rich repeat Acyltransf_C PF16076.5 EDO16413.1 - 2.1e-06 27.7 0.1 6.1e-06 26.2 0.1 1.7 1 0 0 1 1 1 1 Acyltransferase C-terminus Acyltransferase PF01553.21 EDO16413.1 - 0.0063 16.1 0.2 0.024 14.3 0.2 1.9 1 1 1 2 2 2 1 Acyltransferase CybS PF05328.12 EDO16414.1 - 8.5e-51 171.1 0.0 1e-50 170.9 0.0 1.1 1 0 0 1 1 1 1 CybS, succinate dehydrogenase cytochrome B small subunit Membr_traf_MHD PF10540.9 EDO16415.1 - 9.3e-39 133.0 0.1 9.3e-39 133.0 0.1 3.3 4 0 0 4 4 4 1 Munc13 (mammalian uncoordinated) homology domain C2 PF00168.30 EDO16415.1 - 4e-10 39.9 0.0 1.1e-09 38.5 0.0 1.7 1 0 0 1 1 1 1 C2 domain DnaB_2 PF07261.11 EDO16415.1 - 0.0082 15.9 0.0 0.23 11.2 0.0 3.4 2 0 0 2 2 2 1 Replication initiation and membrane attachment Radical_SAM_C PF16199.5 EDO16415.1 - 0.15 12.1 0.9 6.7 6.8 0.1 3.3 3 0 0 3 3 3 0 Radical_SAM C-terminal domain SWIB PF02201.18 EDO16416.1 - 5.3e-26 90.3 0.2 8.6e-26 89.6 0.2 1.3 1 0 0 1 1 1 1 SWIB/MDM2 domain DEK_C PF08766.11 EDO16417.1 - 9.2e-11 41.5 0.1 2e-10 40.4 0.1 1.6 1 0 0 1 1 1 1 DEK C terminal domain Band_3_cyto PF07565.13 EDO16417.1 - 0.33 10.7 4.5 0.43 10.4 4.5 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain RhoGEF PF00621.20 EDO16418.1 - 2.8e-09 37.5 8.3 2.8e-09 37.5 8.3 2.2 2 1 0 2 2 2 1 RhoGEF domain CHU_C PF13585.6 EDO16418.1 - 0.017 15.2 0.4 5.4 7.1 0.1 2.9 2 0 0 2 2 2 0 C-terminal domain of CHU protein family VPS11_C PF12451.8 EDO16419.1 - 1.1e-11 44.8 0.3 1.1e-11 44.8 0.3 2.4 2 0 0 2 2 2 1 Vacuolar protein sorting protein 11 C terminal zf-C3H2C3 PF17122.5 EDO16419.1 - 0.00026 21.0 7.8 0.00077 19.4 7.8 1.9 1 1 0 1 1 1 1 Zinc-finger zf-C3HC4_2 PF13923.6 EDO16419.1 - 0.024 14.5 8.4 0.07 13.0 8.4 1.9 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) TPR_MalT PF17874.1 EDO16419.1 - 0.053 12.9 0.1 0.13 11.6 0.1 1.6 1 0 0 1 1 1 0 MalT-like TPR region zf-RING_UBOX PF13445.6 EDO16419.1 - 0.054 13.5 4.9 0.18 11.9 4.9 2.0 1 0 0 1 1 1 0 RING-type zinc-finger zf-C3HC4_4 PF15227.6 EDO16419.1 - 0.058 13.6 8.2 0.19 11.9 8.2 2.0 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-ANAPC11 PF12861.7 EDO16419.1 - 0.067 13.2 2.3 0.15 12.1 2.3 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_2 PF13639.6 EDO16419.1 - 0.25 11.7 7.8 0.49 10.8 7.8 1.5 1 0 0 1 1 1 0 Ring finger domain zf-RING_5 PF14634.6 EDO16419.1 - 0.26 11.3 8.0 0.68 9.9 8.0 1.8 1 0 0 1 1 1 0 zinc-RING finger domain zf-rbx1 PF12678.7 EDO16419.1 - 0.27 11.5 5.8 0.61 10.4 5.8 1.6 1 0 0 1 1 1 0 RING-H2 zinc finger domain AAA_12 PF13087.6 EDO16419.1 - 0.51 9.9 5.2 0.16 11.5 0.5 2.6 3 0 0 3 3 3 0 AAA domain zf-RING_11 PF17123.5 EDO16419.1 - 1.1 9.1 5.4 2.8 7.8 5.4 1.8 1 0 0 1 1 1 0 RING-like zinc finger Zn_ribbon_17 PF17120.5 EDO16419.1 - 1.7 8.3 5.4 3.2 7.5 5.4 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type PHD PF00628.29 EDO16419.1 - 2.4 8.1 13.0 0.24 11.3 7.8 2.1 2 0 0 2 2 2 0 PHD-finger zf-C3HC4 PF00097.25 EDO16419.1 - 3.4 7.6 9.3 9.1 6.2 9.3 1.8 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) P5-ATPase PF12409.8 EDO16420.1 - 2.1e-34 118.3 0.2 8.3e-34 116.4 0.2 2.1 1 0 0 1 1 1 1 P5-type ATPase cation transporter E1-E2_ATPase PF00122.20 EDO16420.1 - 1.6e-30 105.9 0.9 3.3e-30 105.0 0.1 2.0 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 EDO16420.1 - 3.5e-13 50.3 0.0 6.1e-05 23.4 0.0 3.3 3 0 0 3 3 3 3 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EDO16420.1 - 1.5e-06 28.2 0.0 4.7e-06 26.6 0.0 1.8 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 EDO16420.1 - 0.0013 18.4 0.1 0.005 16.5 0.1 2.0 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 EDO16420.1 - 0.13 12.0 0.0 7.3 6.2 0.0 3.0 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase SNARE_assoc PF09335.11 EDO16421.1 - 1.1e-14 54.9 7.7 1.1e-14 54.9 7.7 2.5 2 1 0 3 3 3 1 SNARE associated Golgi protein TctB PF07331.11 EDO16421.1 - 9.7e-05 22.7 6.5 9.7e-05 22.7 6.5 2.2 2 0 0 2 2 2 1 Tripartite tricarboxylate transporter TctB family DUF4234 PF14018.6 EDO16421.1 - 0.026 14.7 0.1 0.026 14.7 0.1 2.9 2 1 0 2 2 2 0 Domain of unknown function (DUF4234) DUF3382 PF11862.8 EDO16421.1 - 0.29 11.4 6.7 0.24 11.7 1.7 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF3382) DUF2754 PF10953.8 EDO16421.1 - 1.2 9.4 3.8 2.3 8.5 0.9 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF2754) Bac_export_2 PF01312.19 EDO16421.1 - 4.2 6.5 7.7 0.5 9.5 1.4 1.9 1 1 1 2 2 2 0 FlhB HrpN YscU SpaS Family DUF2207 PF09972.9 EDO16421.1 - 5 5.8 11.2 2.7 6.7 7.1 2.2 2 1 0 2 2 2 0 Predicted membrane protein (DUF2207) DUF4231 PF14015.6 EDO16421.1 - 5.4 7.5 5.6 7.1 7.1 0.1 3.0 2 1 0 2 2 2 0 Protein of unknown function (DUF4231) Kin17_mid PF10357.9 EDO16422.1 - 1.1e-44 151.4 7.5 1.1e-44 151.4 7.5 2.0 2 0 0 2 2 2 1 Domain of Kin17 curved DNA-binding protein zf-C2H2_jaz PF12171.8 EDO16422.1 - 4.9e-06 26.7 5.8 4.9e-06 26.7 5.8 2.7 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EDO16422.1 - 2.7e-05 24.4 1.9 2.7e-05 24.4 1.9 2.4 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 EDO16422.1 - 0.0041 17.4 0.6 0.0041 17.4 0.6 3.3 3 1 1 4 4 4 1 C2H2 type zinc-finger (2 copies) Herpes_IE1 PF07340.11 EDO16422.1 - 0.043 12.7 3.1 0.059 12.3 3.1 1.2 1 0 0 1 1 1 0 Cytomegalovirus IE1 protein zf-C2H2_4 PF13894.6 EDO16422.1 - 3.5 8.7 5.7 0.58 11.1 1.1 2.3 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2 PF00096.26 EDO16422.1 - 8.5 7.1 7.5 0.98 10.0 2.5 2.1 2 0 0 2 2 2 0 Zinc finger, C2H2 type RICTOR_N PF14664.6 EDO16423.1 - 2.1e-95 319.9 13.7 4.2e-95 318.9 13.7 1.5 1 0 0 1 1 1 1 Rapamycin-insensitive companion of mTOR, N-term RICTOR_V PF14668.6 EDO16423.1 - 1.7e-27 95.4 3.3 8.3e-27 93.2 0.3 3.9 5 0 0 5 5 5 1 Rapamycin-insensitive companion of mTOR, domain 5 RasGEF_N_2 PF14663.6 EDO16423.1 - 9.5e-27 93.5 1.8 8.6e-26 90.5 1.8 2.9 1 0 0 1 1 1 1 Rapamycin-insensitive companion of mTOR RasGEF_N domain RICTOR_M PF14666.6 EDO16423.1 - 1.1e-26 92.5 12.5 3.2e-26 91.1 0.2 5.9 6 0 0 6 6 6 1 Rapamycin-insensitive companion of mTOR, middle domain HEAT PF02985.22 EDO16423.1 - 0.029 14.6 0.2 7.2 7.2 0.0 3.7 3 0 0 3 3 3 0 HEAT repeat Arm PF00514.23 EDO16423.1 - 0.24 11.5 0.6 51 4.1 0.1 3.4 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat BST2 PF16716.5 EDO16423.1 - 0.59 10.8 7.3 2.5 8.8 7.3 2.2 1 0 0 1 1 1 0 Bone marrow stromal antigen 2 SOGA PF11365.8 EDO16423.1 - 2 9.6 6.1 10 7.3 6.1 2.2 1 0 0 1 1 1 0 Protein SOGA Tup_N PF08581.10 EDO16423.1 - 2.4 8.5 8.5 17 5.8 2.0 3.3 1 1 1 2 2 2 0 Tup N-terminal IES5 PF17335.2 EDO16424.1 - 1.9e-27 95.8 8.5 9.4e-17 61.3 2.8 2.1 1 1 1 2 2 2 2 Ino80 complex subunit 5 HALZ PF02183.18 EDO16424.1 - 0.045 14.0 0.3 0.045 14.0 0.3 2.6 3 0 0 3 3 3 0 Homeobox associated leucine zipper DUF2358 PF10184.9 EDO16424.1 - 0.072 13.4 1.9 0.097 13.0 1.4 1.4 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2358) Vhr1 PF04001.13 EDO16424.1 - 0.09 13.1 0.9 0.13 12.5 0.3 1.6 2 1 0 2 2 2 0 Transcription factor Vhr1 Dimer_Tnp_hAT PF05699.14 EDO16425.1 - 0.0041 16.9 0.1 0.02 14.6 0.1 2.2 2 0 0 2 2 2 1 hAT family C-terminal dimerisation region CcmF_C PF16327.5 EDO16425.1 - 0.21 10.9 0.0 0.33 10.2 0.0 1.2 1 0 0 1 1 1 0 Cytochrome c-type biogenesis protein CcmF C-terminal Meth_synt_2 PF01717.18 EDO16426.1 - 4.9e-146 486.1 0.0 2.4e-143 477.3 0.0 2.3 2 0 0 2 2 2 2 Cobalamin-independent synthase, Catalytic domain Meth_synt_1 PF08267.12 EDO16426.1 - 1.6e-120 402.4 0.0 3.6e-113 378.2 0.0 2.4 3 0 0 3 3 3 2 Cobalamin-independent synthase, N-terminal domain SEP PF08059.13 EDO16427.1 - 8.3e-22 77.6 0.8 1.6e-21 76.6 0.2 1.9 2 0 0 2 2 2 1 SEP domain UBX PF00789.20 EDO16427.1 - 2.6e-14 53.2 0.0 4.4e-14 52.4 0.0 1.4 1 0 0 1 1 1 1 UBX domain UBA_4 PF14555.6 EDO16427.1 - 6.9e-10 38.6 0.4 1.6e-09 37.5 0.4 1.6 1 0 0 1 1 1 1 UBA-like domain Chorismate_bind PF00425.18 EDO16428.1 - 1.7e-88 296.5 0.0 8.2e-88 294.3 0.0 1.8 2 0 0 2 2 2 1 chorismate binding enzyme Anth_synt_I_N PF04715.13 EDO16428.1 - 2.4e-31 108.8 0.0 2.2e-29 102.5 0.0 3.3 4 0 0 4 4 4 1 Anthranilate synthase component I, N terminal region POR PF01558.18 EDO16428.1 - 0.034 14.2 0.0 0.083 12.9 0.0 1.6 1 0 0 1 1 1 0 Pyruvate ferredoxin/flavodoxin oxidoreductase PP2C PF00481.21 EDO16429.1 - 2.2e-79 266.7 0.1 3.4e-79 266.1 0.1 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C MOZ_SAS PF01853.18 EDO16430.1 - 1.3e-72 243.2 0.6 2.5e-72 242.3 0.6 1.5 1 0 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 EDO16430.1 - 1.2e-19 69.6 8.8 3.1e-19 68.3 8.8 1.7 1 0 0 1 1 1 1 MYST family zinc finger domain Acetyltransf_7 PF13508.7 EDO16430.1 - 0.015 15.7 0.0 0.033 14.6 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain RRM_1 PF00076.22 EDO16431.1 - 1.4e-08 34.4 0.1 3.8e-08 33.0 0.1 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Sec61_beta PF03911.16 EDO16432.1 - 1.3e-17 63.5 0.7 1.6e-17 63.2 0.7 1.1 1 0 0 1 1 1 1 Sec61beta family tRNA-synt_2b PF00587.25 EDO16433.1 - 4.4e-37 127.8 0.0 7.9e-37 126.9 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 EDO16433.1 - 0.0067 16.6 0.0 0.015 15.5 0.0 1.5 1 0 0 1 1 1 1 Anticodon binding domain zf-H2C2_2 PF13465.6 EDO16433.1 - 0.022 15.2 2.2 0.054 13.9 2.2 1.6 1 0 0 1 1 1 0 Zinc-finger double domain zf-C2HC_2 PF13913.6 EDO16433.1 - 0.041 13.8 0.5 0.092 12.7 0.5 1.6 1 0 0 1 1 1 0 zinc-finger of a C2HC-type Peroxin-13_N PF04088.13 EDO16435.1 - 9.1e-48 162.2 1.8 1.4e-47 161.6 1.8 1.2 1 0 0 1 1 1 1 Peroxin 13, N-terminal region SH3_9 PF14604.6 EDO16435.1 - 5.8e-10 38.9 0.1 1.2e-09 37.9 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EDO16435.1 - 1.1e-09 37.7 0.1 2.2e-09 36.8 0.1 1.5 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 EDO16435.1 - 3.5e-08 33.0 0.0 7.8e-08 31.9 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_3 PF08239.11 EDO16435.1 - 0.00042 20.5 0.4 0.00089 19.5 0.4 1.5 1 0 0 1 1 1 1 Bacterial SH3 domain Abhydrolase_1 PF00561.20 EDO16436.1 - 1.2e-17 64.4 0.0 1.6e-17 64.0 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EDO16436.1 - 2.8e-17 64.1 0.0 4.1e-17 63.5 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EDO16436.1 - 1.3e-09 37.7 0.0 9.1e-08 31.7 0.0 2.1 1 1 1 2 2 2 1 Serine aminopeptidase, S33 Thioesterase PF00975.20 EDO16436.1 - 0.0033 17.6 0.1 0.034 14.3 0.1 2.4 1 1 0 1 1 1 1 Thioesterase domain LIDHydrolase PF10230.9 EDO16436.1 - 0.0054 16.3 0.0 0.0098 15.5 0.0 1.4 1 1 0 1 1 1 1 Lipid-droplet associated hydrolase DUF2974 PF11187.8 EDO16436.1 - 0.028 14.0 0.0 0.049 13.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) Lipase_3 PF01764.25 EDO16436.1 - 0.14 12.0 0.0 0.27 11.1 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) Flavokinase PF01687.17 EDO16437.1 - 2.6e-10 40.6 0.0 3.1e-10 40.3 0.0 1.2 1 0 0 1 1 1 1 Riboflavin kinase GLE1 PF07817.13 EDO16438.1 - 1.3e-86 289.9 0.1 1.3e-86 289.9 0.1 1.6 2 0 0 2 2 2 1 GLE1-like protein Caldesmon PF02029.15 EDO16438.1 - 0.0015 17.4 31.6 0.0028 16.5 31.6 1.4 1 0 0 1 1 1 1 Caldesmon MAP7 PF05672.11 EDO16438.1 - 0.0031 17.2 49.1 0.0031 17.2 49.1 1.7 2 0 0 2 2 2 1 MAP7 (E-MAP-115) family Neur_chan_memb PF02932.16 EDO16438.1 - 0.074 13.1 7.4 0.11 12.5 7.4 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region V_ATPase_I PF01496.19 EDO16438.1 - 2.5 5.9 14.3 4.2 5.2 14.3 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family YscJ_FliF_C PF08345.11 EDO16438.1 - 6.5 7.1 12.5 14 6.0 12.5 1.6 1 0 0 1 1 1 0 Flagellar M-ring protein C-terminal DUF5401 PF17380.2 EDO16438.1 - 8.2 4.4 38.5 12 3.9 38.5 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5401) CDC45 PF02724.14 EDO16438.1 - 8.6 4.5 25.2 14 3.8 25.2 1.3 1 0 0 1 1 1 0 CDC45-like protein Ribosomal_L5_C PF00673.21 EDO16439.1 - 6.7e-28 96.7 0.0 5e-27 93.9 0.0 2.3 3 0 0 3 3 3 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.19 EDO16439.1 - 4.2e-14 52.6 0.0 1e-13 51.4 0.0 1.6 1 0 0 1 1 1 1 Ribosomal protein L5 PH_17 PF18012.1 EDO16441.1 - 0.0078 15.9 0.0 0.015 15.0 0.0 1.4 1 0 0 1 1 1 1 PH domain KH_8 PF17903.1 EDO16441.1 - 6.5 6.9 7.7 10 6.3 0.2 3.3 3 0 0 3 3 3 0 Krr1 KH1 domain Ribosomal_L7Ae PF01248.26 EDO16442.1 - 1.8e-26 91.7 0.2 2.9e-26 91.1 0.2 1.3 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family COMPASS-Shg1 PF05205.12 EDO16443.1 - 1.3e-23 83.6 4.8 1.6e-23 83.3 4.8 1.1 1 0 0 1 1 1 1 COMPASS (Complex proteins associated with Set1p) component shg1 COMMD1_N PF17221.3 EDO16443.1 - 0.037 14.3 1.4 0.27 11.5 0.3 2.2 1 1 0 2 2 2 0 COMMD1 N-terminal domain RCC_reductase PF06405.11 EDO16444.1 - 0.025 13.8 0.6 0.059 12.6 0.2 1.7 2 0 0 2 2 2 0 Red chlorophyll catabolite reductase (RCC reductase) Tup_N PF08581.10 EDO16444.1 - 1.3 9.4 5.5 3.8 7.9 0.3 3.3 3 0 0 3 3 3 0 Tup N-terminal RhoGAP PF00620.27 EDO16445.1 - 2.1e-40 138.1 0.1 6.5e-39 133.2 0.0 2.5 2 0 0 2 2 2 1 RhoGAP domain FCH PF00611.23 EDO16445.1 - 0.00022 21.4 3.5 0.00075 19.7 3.5 2.0 1 1 0 1 1 1 1 Fes/CIP4, and EFC/F-BAR homology domain AIM5 PF17050.5 EDO16446.1 - 2.3e-05 25.1 0.0 3e-05 24.7 0.0 1.3 1 0 0 1 1 1 1 Altered inheritance of mitochondria 5 P53_TAD PF08563.11 EDO16446.1 - 0.11 12.0 1.6 0.14 11.6 0.3 1.8 2 0 0 2 2 2 0 P53 transactivation motif Ras PF00071.22 EDO16447.1 - 3.5e-38 130.7 0.1 7e-38 129.8 0.1 1.5 1 1 0 1 1 1 1 Ras family Roc PF08477.13 EDO16447.1 - 1.2e-28 99.7 0.1 4.5e-28 97.9 0.1 1.8 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EDO16447.1 - 9.5e-15 54.5 0.2 5.5e-14 52.0 0.2 1.9 1 1 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EDO16447.1 - 6.9e-07 29.0 0.0 5e-06 26.2 0.0 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EDO16447.1 - 1.6e-06 28.2 0.1 2.5e-06 27.6 0.1 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EDO16447.1 - 5.9e-05 22.5 0.0 8.4e-05 22.0 0.0 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 EDO16447.1 - 0.0045 16.5 0.7 0.043 13.3 0.1 2.5 2 1 0 2 2 2 1 Signal recognition particle receptor beta subunit RsgA_GTPase PF03193.16 EDO16447.1 - 0.0099 15.8 0.0 1.2 9.0 0.0 2.2 2 0 0 2 2 2 1 RsgA GTPase MnmE_helical PF12631.7 EDO16447.1 - 0.033 14.4 0.0 0.046 13.9 0.0 1.2 1 0 0 1 1 1 0 MnmE helical domain UBX PF00789.20 EDO16448.1 - 1.1e-17 64.0 0.2 2.6e-17 62.8 0.2 1.6 1 0 0 1 1 1 1 UBX domain DUF4160 PF13711.6 EDO16448.1 - 0.11 12.8 1.0 8.2 6.8 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4160) Snf7 PF03357.21 EDO16449.1 - 3.4e-11 43.0 18.2 4.8e-11 42.6 17.2 1.7 1 1 1 2 2 2 1 Snf7 APG6_N PF17675.1 EDO16449.1 - 0.048 14.2 14.4 4.3 7.9 0.1 2.3 2 0 0 2 2 2 0 Apg6 coiled-coil region USP8_interact PF08941.10 EDO16449.1 - 0.41 10.4 4.0 1.4 8.7 4.0 2.0 1 1 0 1 1 1 0 USP8 interacting CREPT PF16566.5 EDO16449.1 - 2.2 8.4 13.4 0.044 14.0 2.6 2.3 1 1 0 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour Vps26 PF03643.15 EDO16450.1 - 4.5e-110 367.0 0.4 5.6e-110 366.7 0.4 1.1 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 Arrestin_N PF00339.29 EDO16450.1 - 8.8e-05 22.6 0.4 0.0011 19.0 0.3 2.5 2 1 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 EDO16450.1 - 0.00054 20.4 0.1 0.003 18.0 0.0 2.1 2 0 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain Rgp1 PF08737.10 EDO16450.1 - 0.0015 17.8 4.2 0.18 10.9 1.0 2.4 1 1 0 2 2 2 2 Rgp1 Tim54 PF11711.8 EDO16451.1 - 3.6e-128 427.5 0.1 4.2e-128 427.3 0.1 1.0 1 0 0 1 1 1 1 Inner membrane protein import complex subunit Tim54 Lysine_decarbox PF03641.14 EDO16452.1 - 2.4e-42 144.1 0.0 3.2e-42 143.8 0.0 1.1 1 0 0 1 1 1 1 Possible lysine decarboxylase LDcluster4 PF18306.1 EDO16452.1 - 2.2e-12 46.8 0.1 3.7e-12 46.1 0.1 1.4 1 1 0 1 1 1 1 SLOG cluster4 family LSDAT_prok PF18171.1 EDO16452.1 - 0.011 15.0 0.0 0.015 14.5 0.0 1.3 1 0 0 1 1 1 0 SLOG in TRPM, prokaryote Methyltransf_16 PF10294.9 EDO16453.1 - 2e-21 76.5 1.2 2.9e-21 76.0 0.1 1.7 2 0 0 2 2 2 1 Lysine methyltransferase Methyltransf_23 PF13489.6 EDO16453.1 - 0.0026 17.6 0.0 0.0058 16.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDO16453.1 - 0.067 13.0 0.2 0.22 11.3 0.0 2.0 2 2 0 2 2 2 0 Methyltransferase domain Pkinase PF00069.25 EDO16454.1 - 2.6e-33 115.5 0.0 1.2e-32 113.3 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO16454.1 - 8.3e-18 64.6 0.0 1.2e-16 60.8 0.0 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDO16454.1 - 0.033 13.5 0.0 0.15 11.4 0.0 1.9 1 1 0 1 1 1 0 Kinase-like Kdo PF06293.14 EDO16454.1 - 0.059 12.7 0.0 0.1 11.9 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family HbrB PF08539.11 EDO16455.1 - 1.3e-36 126.1 1.1 1.3e-36 126.1 1.1 2.0 2 1 0 2 2 2 1 HbrB-like CLN3 PF02487.17 EDO16456.1 - 2e-149 498.0 16.7 2.2e-149 497.8 16.7 1.0 1 0 0 1 1 1 1 CLN3 protein DUF1674 PF07896.12 EDO16457.1 - 2.3e-19 69.6 0.4 2.3e-19 69.6 0.4 1.8 2 1 0 2 2 2 1 Protein of unknown function (DUF1674) Phage_gp53 PF11246.8 EDO16457.1 - 0.036 13.8 0.0 0.046 13.4 0.0 1.1 1 0 0 1 1 1 0 Base plate wedge protein 53 DSPc PF00782.20 EDO16458.1 - 9.9e-27 93.4 3.5 2.7e-22 79.0 0.3 3.8 3 1 1 4 4 4 3 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EDO16458.1 - 3.3e-05 23.6 0.1 9.2e-05 22.1 0.1 1.7 2 0 0 2 2 2 1 Protein-tyrosine phosphatase CDKN3 PF05706.12 EDO16458.1 - 0.00074 19.2 2.1 0.0014 18.4 0.2 2.4 3 0 0 3 3 3 1 Cyclin-dependent kinase inhibitor 3 (CDKN3) Init_tRNA_PT PF04179.12 EDO16458.1 - 0.12 12.6 0.1 0.12 12.6 0.1 1.9 2 0 0 2 2 2 0 Rit1 DUSP-like domain Paf1 PF03985.13 EDO16459.1 - 2.9e-103 346.1 15.7 2.9e-103 346.1 15.7 1.7 1 1 1 2 2 2 1 Paf1 Esterase PF00756.20 EDO16460.1 - 1.1e-59 202.2 0.0 1.2e-59 202.0 0.0 1.0 1 0 0 1 1 1 1 Putative esterase Hydrolase_4 PF12146.8 EDO16460.1 - 0.067 12.4 0.0 0.089 12.0 0.0 1.2 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 EDO16460.1 - 0.086 12.3 0.0 0.13 11.7 0.0 1.3 1 0 0 1 1 1 0 Prolyl oligopeptidase family Chlorophyllase2 PF12740.7 EDO16460.1 - 0.12 11.3 0.0 0.17 10.7 0.0 1.4 1 0 0 1 1 1 0 Chlorophyllase enzyme Lipase_3 PF01764.25 EDO16460.1 - 0.16 11.8 0.0 0.27 11.1 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) WD40 PF00400.32 EDO16461.1 - 2.7e-13 50.1 1.3 0.00053 20.8 0.0 5.4 5 0 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDO16461.1 - 2.3e-07 31.0 0.0 0.13 12.5 0.0 4.4 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain zf-CCHC PF00098.23 EDO16462.1 - 1.1e-07 31.6 2.4 2.2e-07 30.6 2.4 1.5 1 0 0 1 1 1 1 Zinc knuckle Retrotrans_gag PF03732.17 EDO16462.1 - 0.00029 21.0 0.0 0.00053 20.2 0.0 1.4 1 0 0 1 1 1 1 Retrotransposon gag protein zf-CCHC_3 PF13917.6 EDO16462.1 - 0.015 15.3 1.8 0.031 14.2 1.8 1.6 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_4 PF14392.6 EDO16462.1 - 0.018 14.8 0.7 0.043 13.6 0.7 1.6 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_5 PF14787.6 EDO16462.1 - 0.039 13.6 1.8 0.081 12.6 1.8 1.5 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger Peptidase_A2B PF12384.8 EDO16463.1 - 5.3e-21 74.9 0.0 8e-21 74.4 0.0 1.2 1 0 0 1 1 1 1 Ty3 transposon peptidase gag-asp_proteas PF13975.6 EDO16463.1 - 0.00071 20.1 0.0 0.0011 19.4 0.0 1.3 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 EDO16463.1 - 0.0013 19.3 0.0 0.0023 18.5 0.0 1.4 1 0 0 1 1 1 1 Aspartyl protease DUF1758 PF05585.12 EDO16463.1 - 0.01 15.7 0.0 0.014 15.2 0.0 1.2 1 0 0 1 1 1 1 Putative peptidase (DUF1758) Asp_protease PF09668.10 EDO16463.1 - 0.047 13.5 0.0 0.064 13.0 0.0 1.2 1 0 0 1 1 1 0 Aspartyl protease rve PF00665.26 EDO16464.1 - 6.6e-13 48.9 0.0 9.6e-13 48.4 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain gag_pre-integrs PF13976.6 EDO16464.1 - 0.003 17.4 0.1 0.0058 16.5 0.1 1.5 1 0 0 1 1 1 1 GAG-pre-integrase domain RVT_2 PF07727.14 EDO16466.1 - 1.2e-30 107.0 0.1 1.6e-30 106.6 0.1 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) EntA_Immun PF08951.10 EDO16466.1 - 0.24 11.8 2.0 0.28 11.6 0.2 2.0 2 0 0 2 2 2 0 Enterocin A Immunity RVT_2 PF07727.14 EDO16467.1 - 1e-13 51.5 0.1 1.2e-13 51.3 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Peptidase_C5 PF00770.18 EDO16467.1 - 0.017 14.8 0.2 0.023 14.4 0.2 1.3 1 0 0 1 1 1 0 Adenovirus endoprotease RRM_1 PF00076.22 EDO16468.1 - 2e-09 37.1 0.6 1.9e-05 24.4 0.1 2.8 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 EDO16468.1 - 0.077 13.1 0.4 19 5.4 0.0 2.9 2 1 0 2 2 2 0 Limkain b1 Adaptin_N PF01602.20 EDO16469.1 - 4.7e-118 395.0 15.4 5.7e-118 394.7 15.4 1.1 1 0 0 1 1 1 1 Adaptin N terminal region COP-gamma_platf PF08752.10 EDO16469.1 - 1.3e-49 168.3 1.0 1.3e-49 168.3 1.0 2.3 2 0 0 2 2 2 1 Coatomer gamma subunit appendage platform subdomain Coatomer_g_Cpla PF16381.5 EDO16469.1 - 7.1e-30 103.5 0.0 1.7e-29 102.3 0.0 1.7 1 0 0 1 1 1 1 Coatomer subunit gamma-1 C-terminal appendage platform HEAT_2 PF13646.6 EDO16469.1 - 1.3e-10 41.6 0.2 1.6e-06 28.4 0.0 3.9 3 2 1 4 4 4 2 HEAT repeats Cnd1 PF12717.7 EDO16469.1 - 3.9e-05 23.7 12.2 0.0023 18.0 0.2 4.3 3 1 3 6 6 6 2 non-SMC mitotic condensation complex subunit 1 ThiF PF00899.21 EDO16469.1 - 0.021 14.2 0.0 0.038 13.3 0.0 1.3 1 0 0 1 1 1 0 ThiF family HEAT PF02985.22 EDO16469.1 - 0.057 13.7 3.1 4.2 7.9 0.0 4.7 6 0 0 6 6 6 0 HEAT repeat HEAT_EZ PF13513.6 EDO16469.1 - 0.11 13.0 0.0 0.8 10.3 0.0 2.5 2 0 0 2 2 2 0 HEAT-like repeat Rcd1 PF04078.13 EDO16470.1 - 1.6e-113 378.3 5.3 1.9e-113 378.0 5.3 1.0 1 0 0 1 1 1 1 Cell differentiation family, Rcd1-like DUF4974 PF16344.5 EDO16470.1 - 0.16 12.0 0.0 0.65 10.0 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4974) AAA PF00004.29 EDO16471.1 - 3.6e-17 63.0 0.0 9.7e-17 61.6 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.6 EDO16471.1 - 5.3e-16 58.8 2.0 2.9e-11 43.4 0.1 3.2 2 2 1 3 3 3 2 DNA polymerase III, delta subunit Rep_fac_C PF08542.11 EDO16471.1 - 3e-12 46.8 0.3 3e-12 46.8 0.3 2.4 3 0 0 3 3 2 1 Replication factor C C-terminal domain Rad17 PF03215.15 EDO16471.1 - 2.1e-07 31.0 0.0 9.6e-07 28.9 0.0 2.1 1 1 0 1 1 1 1 Rad17 P-loop domain AAA_assoc_2 PF16193.5 EDO16471.1 - 2.8e-07 30.8 0.4 9.4e-07 29.1 0.4 2.1 1 1 0 1 1 1 1 AAA C-terminal domain RuvB_N PF05496.12 EDO16471.1 - 2.1e-06 27.6 0.0 6.1e-06 26.1 0.0 2.0 2 2 0 2 2 1 1 Holliday junction DNA helicase RuvB P-loop domain ResIII PF04851.15 EDO16471.1 - 7e-06 26.2 0.0 0.0028 17.7 0.0 2.5 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit AAA_11 PF13086.6 EDO16471.1 - 7.8e-06 25.9 0.0 1.2e-05 25.3 0.0 1.4 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EDO16471.1 - 1.6e-05 25.4 0.0 2.6e-05 24.7 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain DUF815 PF05673.13 EDO16471.1 - 1.9e-05 24.0 0.0 3.7e-05 23.0 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_30 PF13604.6 EDO16471.1 - 2.5e-05 24.1 0.0 0.0015 18.3 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_14 PF13173.6 EDO16471.1 - 2.7e-05 24.2 0.2 0.00017 21.6 0.1 2.2 1 1 1 2 2 2 1 AAA domain AAA_22 PF13401.6 EDO16471.1 - 2.7e-05 24.4 1.2 0.26 11.5 0.1 3.1 2 1 1 3 3 3 2 AAA domain AAA_5 PF07728.14 EDO16471.1 - 0.0001 22.3 0.1 0.0021 18.1 0.0 2.8 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_24 PF13479.6 EDO16471.1 - 0.00035 20.3 0.0 0.00065 19.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_7 PF12775.7 EDO16471.1 - 0.0008 19.0 0.0 0.002 17.6 0.0 1.7 1 0 0 1 1 1 1 P-loop containing dynein motor region DEAD PF00270.29 EDO16471.1 - 0.001 18.9 0.2 0.0057 16.4 0.2 2.1 1 1 0 1 1 1 1 DEAD/DEAH box helicase IstB_IS21 PF01695.17 EDO16471.1 - 0.0011 18.7 0.0 0.0028 17.4 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein DNA_pol3_delta PF06144.13 EDO16471.1 - 0.0015 18.4 0.2 0.0015 18.4 0.2 1.8 2 1 1 3 3 2 1 DNA polymerase III, delta subunit UvrD-helicase PF00580.21 EDO16471.1 - 0.0033 17.0 0.6 0.12 11.9 0.4 2.2 2 1 0 2 2 2 1 UvrD/REP helicase N-terminal domain PARP_reg PF02877.14 EDO16471.1 - 0.0047 17.0 0.6 0.0089 16.1 0.6 1.4 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase, regulatory domain TIP49 PF06068.13 EDO16471.1 - 0.0048 16.2 0.0 0.0099 15.1 0.0 1.6 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_18 PF13238.6 EDO16471.1 - 0.0053 17.3 0.3 0.044 14.3 0.0 2.3 1 1 0 2 2 2 1 AAA domain AAA_19 PF13245.6 EDO16471.1 - 0.011 16.1 1.6 0.34 11.2 0.1 2.8 2 2 1 3 3 3 0 AAA domain AAA_3 PF07726.11 EDO16471.1 - 0.014 15.2 0.0 0.03 14.2 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.21 EDO16471.1 - 0.018 14.5 0.0 0.11 11.9 0.0 2.1 1 1 1 2 2 2 0 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 EDO16471.1 - 0.018 15.4 0.0 0.043 14.2 0.0 1.8 1 1 0 1 1 1 0 RNA helicase SNF2_N PF00176.23 EDO16471.1 - 0.019 13.7 0.2 0.047 12.4 0.1 1.8 2 1 0 2 2 2 0 SNF2 family N-terminal domain Viral_helicase1 PF01443.18 EDO16471.1 - 0.019 14.7 0.0 0.031 14.0 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase ATPase_2 PF01637.18 EDO16471.1 - 0.024 14.6 1.0 0.035 14.0 0.1 1.7 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea AAA_28 PF13521.6 EDO16471.1 - 0.03 14.6 0.0 0.058 13.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain Methyltransf_31 PF13847.6 EDO16471.1 - 0.044 13.6 0.9 0.19 11.5 0.2 2.2 1 1 1 3 3 3 0 Methyltransferase domain TniB PF05621.11 EDO16471.1 - 0.063 12.7 0.1 1.5 8.2 0.0 2.4 1 1 1 2 2 2 0 Bacterial TniB protein DUF2075 PF09848.9 EDO16471.1 - 0.07 12.4 0.2 0.39 9.9 0.1 2.0 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_25 PF13481.6 EDO16471.1 - 0.071 12.7 0.1 1.7 8.2 0.0 2.4 1 1 1 2 2 2 0 AAA domain AAA_33 PF13671.6 EDO16471.1 - 0.081 13.1 0.0 0.22 11.7 0.0 1.8 1 1 0 1 1 1 0 AAA domain Mid1 PF12929.7 EDO16472.1 - 9e-121 404.0 12.7 1.1e-120 403.8 12.7 1.0 1 0 0 1 1 1 1 Stretch-activated Ca2+-permeable channel component Fz PF01392.22 EDO16472.1 - 0.0083 16.7 4.7 0.27 11.9 3.8 2.8 2 1 0 2 2 2 1 Fz domain Erf4 PF10256.9 EDO16473.1 - 2.6e-32 111.3 0.0 3.8e-32 110.8 0.0 1.3 1 0 0 1 1 1 1 Golgin subfamily A member 7/ERF4 family DUF1894 PF08979.11 EDO16473.1 - 0.011 16.1 0.0 0.027 14.8 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1894) Get5_bdg PF16843.5 EDO16474.1 - 4.5e-31 106.1 1.1 1.6e-30 104.4 0.8 2.1 2 0 0 2 2 2 1 Binding domain to Get4 on Get5, Golgi to ER traffic protein Get5_C PF18514.1 EDO16474.1 - 3.4e-20 71.4 1.3 3.4e-20 71.4 1.3 1.9 2 0 0 2 2 2 1 Get5 C-terminal domain ubiquitin PF00240.23 EDO16474.1 - 3.4e-09 36.3 0.5 7.4e-09 35.2 0.5 1.6 1 0 0 1 1 1 1 Ubiquitin family Blt1 PF12754.7 EDO16474.1 - 1.3e-05 25.6 2.7 0.0002 21.7 0.6 2.1 1 1 1 2 2 2 1 Blt1 N-terminal domain Rad60-SLD_2 PF13881.6 EDO16474.1 - 0.00018 21.6 0.5 0.00034 20.7 0.5 1.5 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like RabGAP-TBC PF00566.18 EDO16475.1 - 3e-42 144.7 10.5 3e-42 144.7 10.5 3.3 2 1 0 2 2 2 1 Rab-GTPase-TBC domain PalH PF08733.10 EDO16476.1 - 4.6e-81 272.4 19.3 5.6e-81 272.1 19.3 1.1 1 0 0 1 1 1 1 PalH/RIM21 Pet20 PF08692.10 EDO16477.1 - 9.5e-27 94.3 4.9 1.3e-26 93.9 0.0 3.0 4 0 0 4 4 4 1 Mitochondrial protein Pet20 DUF2536 PF10750.9 EDO16477.1 - 8.6 6.3 7.5 4.2 7.3 1.3 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF2536) Pkinase PF00069.25 EDO16478.1 - 1e-64 218.5 0.4 1.5e-63 214.6 0.4 2.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO16478.1 - 1.4e-50 172.1 0.1 2.4e-50 171.2 0.1 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.28 EDO16478.1 - 8.2e-24 83.7 0.2 3.5e-23 81.7 0.2 2.2 1 0 0 1 1 1 1 P21-Rho-binding domain PH PF00169.29 EDO16478.1 - 1.1e-07 32.3 3.4 1.2e-07 32.2 1.1 2.3 2 1 0 2 2 2 1 PH domain Pkinase_fungal PF17667.1 EDO16478.1 - 5e-06 25.5 0.0 5e-06 25.5 0.0 2.2 3 1 0 3 3 3 1 Fungal protein kinase Kinase-like PF14531.6 EDO16478.1 - 0.00019 20.9 0.0 0.00032 20.1 0.0 1.4 1 0 0 1 1 1 1 Kinase-like PH_11 PF15413.6 EDO16478.1 - 0.00027 21.3 0.8 0.00027 21.3 0.8 2.3 2 0 0 2 2 2 1 Pleckstrin homology domain APH PF01636.23 EDO16478.1 - 0.11 12.4 0.1 0.28 11.1 0.1 1.6 1 1 1 2 2 2 0 Phosphotransferase enzyme family Pkinase PF00069.25 EDO16479.1 - 4.5e-69 232.8 2.2 7.5e-67 225.5 2.2 2.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO16479.1 - 5.8e-40 137.2 0.5 5.1e-38 130.8 0.0 2.5 1 1 0 2 2 2 1 Protein tyrosine kinase KA1 PF02149.19 EDO16479.1 - 4.5e-18 64.8 0.0 9.1e-18 63.8 0.0 1.6 1 0 0 1 1 1 1 Kinase associated domain 1 Kinase-like PF14531.6 EDO16479.1 - 6.8e-09 35.5 1.2 2.9e-08 33.4 0.0 2.2 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 EDO16479.1 - 1.3e-05 24.7 0.2 4.4e-05 22.9 0.2 1.8 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EDO16479.1 - 0.0016 17.3 0.0 0.0016 17.3 0.0 3.9 3 1 0 3 3 3 1 Fungal protein kinase APH PF01636.23 EDO16479.1 - 0.0058 16.6 0.1 0.059 13.3 0.1 2.1 1 1 1 2 2 2 1 Phosphotransferase enzyme family HLH PF00010.26 EDO16480.1 - 0.036 14.0 0.3 0.08 12.9 0.3 1.6 1 0 0 1 1 1 0 Helix-loop-helix DNA-binding domain ketoacyl-synt PF00109.26 EDO16481.1 - 1.6e-53 181.9 0.0 2.3e-53 181.4 0.0 1.2 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 EDO16481.1 - 2.6e-29 101.6 0.3 4.5e-29 100.8 0.3 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Thiolase_N PF00108.23 EDO16481.1 - 0.0015 17.9 0.1 0.0031 16.9 0.1 1.4 1 0 0 1 1 1 1 Thiolase, N-terminal domain Tho1_MOS11_C PF18592.1 EDO16482.1 - 1.5e-26 92.0 3.7 1.5e-26 92.0 3.7 1.9 2 0 0 2 2 2 1 Tho1/MOS11 C-terminal domain SAP PF02037.27 EDO16482.1 - 3.5e-13 48.9 0.6 8.1e-13 47.8 0.6 1.7 1 0 0 1 1 1 1 SAP domain DUF4205 PF13898.6 EDO16482.1 - 0.84 8.5 6.4 0.037 13.0 0.9 1.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4205) SOBP PF15279.6 EDO16482.1 - 6.5 7.3 8.1 7.7 7.0 8.1 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein Vhr1 PF04001.13 EDO16484.1 - 1e-45 153.9 4.0 2.4e-45 152.7 4.0 1.7 1 0 0 1 1 1 1 Transcription factor Vhr1 Glyco_transf_15 PF01793.16 EDO16485.1 - 6.7e-134 446.2 9.7 1.1e-133 445.5 9.7 1.3 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase TPR_1 PF00515.28 EDO16486.1 - 2.9e-11 42.7 10.5 1.2e-05 24.9 1.1 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 EDO16486.1 - 1.2e-08 34.4 5.4 0.0093 16.0 0.4 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EDO16486.1 - 0.00075 19.7 3.5 0.0016 18.6 3.5 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.6 EDO16486.1 - 0.0012 18.5 0.5 1.5 8.6 0.2 2.6 2 0 0 2 2 2 2 TPR repeat TPR_17 PF13431.6 EDO16486.1 - 0.0029 17.9 1.5 0.19 12.2 0.0 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 EDO16486.1 - 0.011 16.0 0.7 0.72 10.2 0.0 2.5 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 EDO16486.1 - 0.023 15.5 0.0 2.4 9.2 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.6 EDO16486.1 - 0.052 14.1 0.3 4.6 7.8 0.0 2.4 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_16 PF13432.6 EDO16486.1 - 0.076 13.7 0.1 0.16 12.6 0.1 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_8 PF13181.6 EDO16486.1 - 0.16 12.2 5.3 4 7.9 0.4 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EDO16486.1 - 0.38 10.9 4.4 14 5.8 0.2 3.2 2 1 1 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat INCENP_ARK-bind PF03941.15 EDO16487.1 - 7.5e-17 61.0 1.9 1.8e-16 59.8 1.9 1.7 1 0 0 1 1 1 1 Inner centromere protein, ARK binding region T4BSS_DotI_IcmL PF11393.8 EDO16487.1 - 0.082 12.4 0.2 0.15 11.5 0.2 1.4 1 0 0 1 1 1 0 Type-IV b secretion system, inner-membrane complex component MAD PF05557.13 EDO16489.1 - 0.0014 17.1 0.2 0.0022 16.5 0.2 1.2 1 0 0 1 1 1 1 Mitotic checkpoint protein LRR_6 PF13516.6 EDO16489.1 - 0.012 15.6 14.3 0.028 14.5 0.0 5.3 6 0 0 6 6 6 0 Leucine Rich repeat F-box-like PF12937.7 EDO16489.1 - 0.015 15.2 0.2 0.068 13.1 0.0 2.3 2 1 0 2 2 2 0 F-box-like TraH PF06122.11 EDO16489.1 - 0.019 14.3 0.1 0.031 13.6 0.1 1.3 1 0 0 1 1 1 0 Conjugative relaxosome accessory transposon protein DUF1524 PF07510.11 EDO16489.1 - 0.028 14.3 3.6 0.47 10.3 3.6 2.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1524) Recep_L_domain PF01030.24 EDO16489.1 - 0.1 12.7 0.1 0.1 12.7 0.1 3.0 3 1 0 3 3 3 0 Receptor L domain LRR_4 PF12799.7 EDO16489.1 - 0.15 12.5 0.0 0.15 12.5 0.0 6.1 4 1 3 8 8 8 0 Leucine Rich repeats (2 copies) adh_short PF00106.25 EDO16490.1 - 1.7e-35 122.3 0.1 2.2e-35 121.9 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EDO16490.1 - 1.9e-20 73.4 0.0 2.5e-20 73.1 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EDO16490.1 - 1.7e-08 34.6 0.0 3.6e-08 33.5 0.0 1.6 1 1 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 EDO16490.1 - 0.02 14.1 0.3 0.039 13.1 0.3 1.5 1 1 0 1 1 1 0 Polysaccharide biosynthesis protein Sacchrp_dh_NADP PF03435.18 EDO16490.1 - 0.055 13.7 0.0 0.15 12.3 0.0 1.8 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain T_Ag_DNA_bind PF02217.16 EDO16490.1 - 0.098 13.3 0.2 0.4 11.3 0.0 2.2 2 0 0 2 2 2 0 Origin of replication binding protein Pkinase PF00069.25 EDO16491.1 - 1.5e-72 244.2 0.0 1.7e-72 244.0 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO16491.1 - 3.5e-32 111.7 0.0 4.3e-32 111.4 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDO16491.1 - 3.8e-05 23.1 0.0 6.7e-05 22.4 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 EDO16491.1 - 0.0021 17.1 0.0 0.015 14.3 0.0 2.0 1 1 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 EDO16491.1 - 0.0026 17.7 0.4 0.055 13.4 0.2 2.1 1 1 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 EDO16491.1 - 0.01 15.2 0.1 0.034 13.5 0.1 1.9 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF2401 PF10287.9 EDO16492.1 - 3.7e-94 314.6 1.2 3.7e-94 314.6 1.2 2.2 2 0 0 2 2 1 1 Putative TOS1-like glycosyl hydrolase (DUF2401) DUF2403 PF10290.9 EDO16492.1 - 1.3e-28 99.2 0.1 1.3e-28 99.2 0.1 2.1 2 0 0 2 2 1 1 Glycine-rich protein domain (DUF2403) GREB1 PF15782.5 EDO16492.1 - 0.14 9.3 7.2 0.16 9.0 7.2 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Menin PF05053.13 EDO16492.1 - 0.21 9.9 14.0 0.28 9.5 14.0 1.1 1 0 0 1 1 1 0 Menin Apt1 PF10351.9 EDO16492.1 - 0.27 10.0 8.0 0.34 9.7 8.0 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Macoilin PF09726.9 EDO16492.1 - 1.8 7.0 14.9 2.4 6.6 14.9 1.1 1 0 0 1 1 1 0 Macoilin family PI3K_1B_p101 PF10486.9 EDO16492.1 - 1.8 6.2 7.3 2.5 5.7 7.3 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit MMU163 PF17119.5 EDO16492.1 - 2 7.5 5.1 3.7 6.6 5.1 1.4 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis SR-25 PF10500.9 EDO16492.1 - 4.1 6.9 23.5 0.73 9.4 19.7 1.6 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein TMEM151 PF14857.6 EDO16492.1 - 4.7 6.0 6.9 6.3 5.6 6.9 1.1 1 0 0 1 1 1 0 TMEM151 family Presenilin PF01080.17 EDO16492.1 - 5.6 5.6 8.4 7.6 5.2 8.4 1.1 1 0 0 1 1 1 0 Presenilin ABC2_membrane PF01061.24 EDO16493.1 - 7.5e-68 228.1 52.3 7.3e-38 130.1 14.1 2.8 3 0 0 3 3 3 2 ABC-2 type transporter ABC_tran PF00005.27 EDO16493.1 - 1.3e-36 126.2 0.0 9.6e-18 65.0 0.0 2.6 2 0 0 2 2 2 2 ABC transporter PDR_CDR PF06422.12 EDO16493.1 - 3.8e-30 103.6 6.4 3.5e-26 90.9 0.0 2.9 2 0 0 2 2 2 2 CDR ABC transporter ABC_trans_N PF14510.6 EDO16493.1 - 7e-10 39.4 0.0 1.6e-09 38.2 0.0 1.6 1 0 0 1 1 1 1 ABC-transporter N-terminal RsgA_GTPase PF03193.16 EDO16493.1 - 3.5e-07 30.3 0.0 8.4e-05 22.5 0.0 2.5 2 0 0 2 2 2 1 RsgA GTPase AAA_16 PF13191.6 EDO16493.1 - 9.8e-06 26.0 0.0 0.0042 17.5 0.0 2.6 2 0 0 2 2 2 1 AAA ATPase domain SMC_N PF02463.19 EDO16493.1 - 0.00017 21.1 0.0 1.4 8.3 0.0 3.2 3 0 0 3 3 3 2 RecF/RecN/SMC N terminal domain ABC2_membrane_3 PF12698.7 EDO16493.1 - 0.00031 20.0 8.9 0.00031 20.0 8.9 3.3 3 0 0 3 3 3 1 ABC-2 family transporter protein MMR_HSR1 PF01926.23 EDO16493.1 - 0.00055 20.0 0.2 0.63 10.1 0.1 2.5 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_22 PF13401.6 EDO16493.1 - 0.00059 20.1 0.1 0.084 13.1 0.0 2.9 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 EDO16493.1 - 0.00069 19.3 0.2 0.098 12.4 0.1 2.6 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_18 PF13238.6 EDO16493.1 - 0.0044 17.6 0.0 0.077 13.5 0.0 2.6 2 0 0 2 2 2 1 AAA domain cobW PF02492.19 EDO16493.1 - 0.0053 16.4 0.2 0.06 12.9 0.1 2.2 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_25 PF13481.6 EDO16493.1 - 0.0071 15.9 0.0 0.29 10.7 0.0 2.3 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.12 EDO16493.1 - 0.0082 15.4 0.0 1.2 8.4 0.0 2.5 2 0 0 2 2 2 1 Zeta toxin AAA_30 PF13604.6 EDO16493.1 - 0.0091 15.7 0.4 0.85 9.3 0.1 2.3 2 0 0 2 2 2 1 AAA domain AAA_21 PF13304.6 EDO16493.1 - 0.0091 15.8 0.0 5.6 6.7 0.0 2.4 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system NACHT PF05729.12 EDO16493.1 - 0.0097 15.8 0.0 0.12 12.3 0.0 2.4 2 0 0 2 2 2 1 NACHT domain NTPase_1 PF03266.15 EDO16493.1 - 0.018 15.0 0.0 14 5.6 0.0 3.4 3 0 0 3 3 3 0 NTPase Ploopntkinase3 PF18751.1 EDO16493.1 - 0.06 13.2 0.1 8.1 6.3 0.0 2.6 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 TsaE PF02367.17 EDO16493.1 - 0.072 13.1 0.5 0.2 11.7 0.1 1.9 2 0 0 2 2 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_33 PF13671.6 EDO16493.1 - 0.082 13.1 0.0 1.3 9.2 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.6 EDO16493.1 - 0.094 13.2 0.0 0.49 10.9 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 EDO16493.1 - 0.1 12.3 0.1 2.1 8.0 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_17 PF13207.6 EDO16493.1 - 0.15 12.5 0.1 0.57 10.6 0.0 2.0 2 0 0 2 2 2 0 AAA domain SbcCD_C PF13558.6 EDO16493.1 - 0.15 12.3 0.1 25 5.2 0.0 3.4 3 0 0 3 3 3 0 Putative exonuclease SbcCD, C subunit DUF4079 PF13301.6 EDO16493.1 - 1.9 8.6 4.9 7.9 6.6 4.9 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF4079) Exo5 PF09810.9 EDO16494.1 - 4.8e-69 233.6 0.0 6.1e-69 233.3 0.0 1.1 1 0 0 1 1 1 1 Exonuclease V - a 5' deoxyribonuclease PDDEXK_1 PF12705.7 EDO16494.1 - 0.083 12.8 2.5 2.3 8.1 2.5 2.7 1 1 0 1 1 1 0 PD-(D/E)XK nuclease superfamily Glutaredoxin PF00462.24 EDO16495.1 - 8.7e-18 64.3 0.0 1.3e-17 63.8 0.0 1.3 1 0 0 1 1 1 1 Glutaredoxin DDDD PF10161.9 EDO16495.1 - 0.086 12.6 0.0 0.15 11.9 0.0 1.4 1 0 0 1 1 1 0 Putative mitochondrial precursor protein Raptor_N PF14538.6 EDO16496.1 - 8e-67 223.8 0.9 5.7e-65 217.8 0.0 2.7 2 0 0 2 2 2 1 Raptor N-terminal CASPase like domain HEAT PF02985.22 EDO16496.1 - 2.4e-05 24.2 0.0 0.027 14.7 0.0 4.3 4 0 0 4 4 4 1 HEAT repeat ANAPC4_WD40 PF12894.7 EDO16496.1 - 6.3e-05 23.2 0.3 0.39 11.1 0.1 4.0 2 2 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Cnd1 PF12717.7 EDO16496.1 - 0.00054 20.0 1.9 0.044 13.8 1.0 3.0 1 1 2 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EDO16496.1 - 0.0076 16.6 0.0 0.12 12.8 0.0 2.8 2 0 0 2 2 2 1 HEAT repeats V-ATPase_H_C PF11698.8 EDO16496.1 - 0.023 14.8 0.2 0.14 12.3 0.0 2.5 2 0 0 2 2 2 0 V-ATPase subunit H CTNNB1_binding PF08347.11 EDO16496.1 - 0.03 14.5 0.3 0.03 14.5 0.3 2.4 3 0 0 3 3 3 0 N-terminal CTNNB1 binding RTP1_C1 PF10363.9 EDO16496.1 - 0.036 14.3 0.7 0.14 12.4 0.7 2.1 1 0 0 1 1 1 0 Required for nuclear transport of RNA pol II C-terminus 1 WD40 PF00400.32 EDO16496.1 - 0.038 14.9 8.7 2.4 9.2 0.0 5.7 5 1 1 6 6 6 0 WD domain, G-beta repeat DUF725 PF05267.12 EDO16496.1 - 0.12 12.4 7.2 0.07 13.1 4.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF725) SLATT_6 PF18169.1 EDO16496.1 - 1.9 8.0 4.8 1.9 8.0 1.4 2.7 3 0 0 3 3 3 0 SMODS and SLOG-associating 2TM effector domain 6 Exonuc_VII_L PF02601.15 EDO16496.1 - 3.1 7.3 11.6 0.2 11.2 3.3 2.4 2 0 0 2 2 2 0 Exonuclease VII, large subunit Not3 PF04065.15 EDO16496.1 - 6.3 6.1 15.8 0.88 9.0 8.7 2.3 2 0 0 2 2 2 0 Not1 N-terminal domain, CCR4-Not complex component Elong_Iki1 PF10483.9 EDO16497.1 - 7.2e-74 249.0 2.0 8.2e-74 248.8 2.0 1.0 1 0 0 1 1 1 1 Elongator subunit Iki1 DUF1869 PF08956.10 EDO16497.1 - 0.042 13.8 0.1 1.5 8.8 0.3 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF1869) Gpi16 PF04113.14 EDO16498.1 - 4.3e-33 114.6 0.1 5.8e-33 114.2 0.1 1.0 1 0 0 1 1 1 1 Gpi16 subunit, GPI transamidase component GRDP-like PF07173.12 EDO16498.1 - 0.096 13.3 1.1 0.29 11.8 0.2 2.0 2 0 0 2 2 2 0 Glycine-rich domain-containing protein-like DEAD PF00270.29 EDO16499.1 - 1.4e-47 161.8 0.8 2.6e-47 160.9 0.0 1.9 3 0 0 3 3 3 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDO16499.1 - 2.4e-25 89.0 0.1 1.6e-24 86.4 0.0 2.3 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 EDO16499.1 - 1.1e-18 67.2 0.2 2.3e-18 66.1 0.2 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 EDO16499.1 - 5.4e-06 26.5 0.0 1e-05 25.6 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 EDO16499.1 - 8.3e-05 21.9 0.0 0.00023 20.5 0.0 1.7 2 0 0 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase SecA_DEAD PF07517.14 EDO16499.1 - 0.0047 16.3 0.0 0.012 15.0 0.0 1.5 1 1 0 1 1 1 1 SecA DEAD-like domain AAA_30 PF13604.6 EDO16499.1 - 0.067 12.9 0.0 0.83 9.3 0.0 2.3 1 1 0 1 1 1 0 AAA domain AAA_22 PF13401.6 EDO16499.1 - 0.16 12.2 1.1 0.68 10.2 1.1 2.2 1 1 0 1 1 1 0 AAA domain PhoD PF09423.10 EDO16500.1 - 0.00025 20.2 0.1 0.97 8.4 0.0 3.0 3 0 0 3 3 3 3 PhoD-like phosphatase Pkinase PF00069.25 EDO16501.1 - 6.1e-50 170.0 1.7 1.3e-41 142.7 0.1 3.2 3 0 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 EDO16501.1 - 2.1e-24 86.2 0.1 8.3e-22 77.7 0.0 3.1 3 0 0 3 3 3 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EDO16501.1 - 0.00095 18.0 0.1 0.00095 18.0 0.1 2.1 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 EDO16501.1 - 0.031 13.6 0.1 7.4 5.8 0.0 2.2 2 0 0 2 2 2 0 Kinase-like DnaJ_CXXCXGXG PF00684.19 EDO16502.1 - 2.6e-05 24.5 4.8 0.082 13.3 0.3 2.3 2 0 0 2 2 2 2 DnaJ central domain DZR PF12773.7 EDO16502.1 - 0.023 14.7 3.0 0.48 10.5 0.5 2.5 2 0 0 2 2 2 0 Double zinc ribbon Anti-TRAP PF15777.5 EDO16502.1 - 0.05 13.6 0.6 0.05 13.6 0.6 2.7 2 2 1 3 3 3 0 Tryptophan RNA-binding attenuator protein inhibitory protein HypA PF01155.19 EDO16502.1 - 0.16 12.0 2.2 5.4 7.1 0.6 2.2 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA TMEM51 PF15345.6 EDO16502.1 - 1.6 8.5 6.3 0.66 9.8 3.1 1.8 2 0 0 2 2 2 0 Transmembrane protein 51 zf-RING_5 PF14634.6 EDO16502.1 - 3.5 7.7 6.9 21 5.2 2.6 2.7 2 1 1 3 3 3 0 zinc-RING finger domain AAA PF00004.29 EDO16503.1 - 5.5e-49 166.0 2.5 1.4e-42 145.2 0.0 3.9 4 0 0 4 4 4 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EDO16503.1 - 7.3e-10 38.5 0.1 4.9e-09 35.8 0.0 2.3 2 0 0 2 2 2 1 AAA+ lid domain AAA_2 PF07724.14 EDO16503.1 - 3.3e-06 27.3 0.0 5.7e-05 23.3 0.0 2.6 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 EDO16503.1 - 4.6e-05 23.9 0.1 0.00032 21.1 0.0 2.4 2 1 0 2 2 2 1 AAA ATPase domain AAA_5 PF07728.14 EDO16503.1 - 5e-05 23.3 0.0 0.00015 21.8 0.0 1.8 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.17 EDO16503.1 - 5.9e-05 22.9 0.0 0.00014 21.6 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein Bromodomain PF00439.25 EDO16503.1 - 0.0003 20.8 0.0 0.0015 18.6 0.0 2.2 1 0 0 1 1 1 1 Bromodomain Sigma54_activ_2 PF14532.6 EDO16503.1 - 0.00076 19.6 0.3 0.64 10.1 0.0 3.0 3 0 0 3 3 3 1 Sigma-54 interaction domain ResIII PF04851.15 EDO16503.1 - 0.0011 19.0 0.1 0.0067 16.4 0.0 2.4 2 0 0 2 2 1 1 Type III restriction enzyme, res subunit Sigma54_activat PF00158.26 EDO16503.1 - 0.009 15.7 0.0 1.3 8.7 0.0 3.1 2 1 0 2 2 2 1 Sigma-54 interaction domain TIP49 PF06068.13 EDO16503.1 - 0.011 14.9 0.0 0.034 13.3 0.0 1.7 2 0 0 2 2 2 0 TIP49 P-loop domain AAA_25 PF13481.6 EDO16503.1 - 0.017 14.7 0.0 0.046 13.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 EDO16503.1 - 0.022 14.9 0.0 0.086 13.0 0.0 2.1 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.6 EDO16503.1 - 0.024 14.6 0.0 0.11 12.5 0.0 2.2 2 0 0 2 2 1 0 AAA domain RNA_helicase PF00910.22 EDO16503.1 - 0.025 15.0 0.2 0.14 12.6 0.0 2.4 3 0 0 3 3 1 0 RNA helicase AAA_22 PF13401.6 EDO16503.1 - 0.046 14.0 1.6 0.32 11.2 0.2 2.9 2 1 0 2 2 1 0 AAA domain AAA_18 PF13238.6 EDO16503.1 - 0.049 14.2 0.3 0.35 11.4 0.0 2.8 2 0 0 2 2 1 0 AAA domain Mg_chelatase PF01078.21 EDO16503.1 - 0.05 13.0 0.1 0.17 11.3 0.1 1.8 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI RuvB_N PF05496.12 EDO16503.1 - 0.053 13.3 0.0 0.14 11.9 0.0 1.7 1 1 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain NTP_transf_6 PF06042.11 EDO16503.1 - 0.07 13.0 0.2 0.23 11.3 0.2 1.8 1 1 0 1 1 1 0 Nucleotidyltransferase ABC_tran PF00005.27 EDO16503.1 - 0.075 13.5 2.4 0.27 11.8 0.0 3.0 3 0 0 3 3 3 0 ABC transporter AAA_3 PF07726.11 EDO16503.1 - 0.087 12.7 0.0 0.25 11.2 0.0 1.8 2 0 0 2 2 1 0 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 EDO16503.1 - 0.091 12.3 0.0 0.43 10.1 0.0 2.1 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_30 PF13604.6 EDO16503.1 - 0.16 11.7 0.0 0.44 10.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.6 EDO16503.1 - 0.63 9.8 0.0 0.63 9.8 0.0 3.4 3 1 0 3 3 2 0 AAA domain Efg1 PF10153.9 EDO16504.1 - 2.3e-33 114.9 13.0 2.3e-33 114.9 13.0 1.9 2 1 0 2 2 2 1 rRNA-processing protein Efg1 VanY PF02557.17 EDO16504.1 - 0.032 14.0 0.5 1.6 8.5 0.1 2.5 1 1 1 2 2 2 0 D-alanyl-D-alanine carboxypeptidase DUF3591 PF12157.8 EDO16505.1 - 2.9e-167 556.8 0.5 4.7e-167 556.1 0.5 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3591) zf-CCHC_6 PF15288.6 EDO16505.1 - 8.7e-06 25.5 0.7 1.9e-05 24.4 0.7 1.5 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC PF00098.23 EDO16505.1 - 0.13 12.4 1.7 0.14 12.3 0.4 1.8 2 0 0 2 2 2 0 Zinc knuckle CitF PF04223.12 EDO16505.1 - 0.15 10.9 0.0 0.26 10.1 0.0 1.3 1 0 0 1 1 1 0 Citrate lyase, alpha subunit (CitF) UCMA PF17085.5 EDO16505.1 - 4.4 7.3 7.3 0.84 9.7 0.1 3.4 3 0 0 3 3 3 0 Unique cartilage matrix associated protein RNase_T PF00929.24 EDO16506.1 - 4e-08 34.0 0.0 1.1e-07 32.6 0.0 1.8 1 0 0 1 1 1 1 Exonuclease ABC_membrane PF00664.23 EDO16507.1 - 2e-41 142.5 15.7 2.5e-41 142.1 15.7 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 EDO16507.1 - 5.9e-35 120.8 0.0 1.3e-34 119.6 0.0 1.6 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 EDO16507.1 - 1.5e-07 31.1 0.3 0.00033 20.1 0.0 2.4 1 1 1 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EDO16507.1 - 0.00047 19.9 0.4 0.0031 17.2 0.1 2.3 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_16 PF13191.6 EDO16507.1 - 0.0022 18.4 0.0 0.0055 17.1 0.0 1.9 1 1 0 1 1 1 1 AAA ATPase domain AAA_21 PF13304.6 EDO16507.1 - 0.0048 16.8 0.1 0.024 14.4 0.1 2.0 1 1 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 EDO16507.1 - 0.0048 17.2 0.0 0.024 14.9 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 EDO16507.1 - 0.012 16.1 0.0 0.092 13.2 0.0 2.2 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Gtr1_RagA PF04670.12 EDO16507.1 - 0.023 14.1 0.0 0.044 13.1 0.0 1.5 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region AAA_24 PF13479.6 EDO16507.1 - 0.029 14.1 0.0 0.05 13.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 EDO16507.1 - 0.039 13.7 0.0 0.14 11.9 0.0 1.9 3 0 0 3 3 3 0 AAA domain ABC_ATPase PF09818.9 EDO16507.1 - 0.063 12.1 0.0 1.3 7.7 0.0 2.3 2 0 0 2 2 2 0 Predicted ATPase of the ABC class AAA_25 PF13481.6 EDO16507.1 - 0.081 12.5 0.1 0.37 10.3 0.0 1.9 2 0 0 2 2 2 0 AAA domain ACTL7A_N PF16840.5 EDO16507.1 - 0.089 12.9 0.7 0.18 11.9 0.7 1.4 1 0 0 1 1 1 0 Actin-like protein 7A N-terminus SbcCD_C PF13558.6 EDO16507.1 - 0.2 11.9 0.3 1.5 9.1 0.3 2.3 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_23 PF13476.6 EDO16507.1 - 0.29 11.6 7.1 0.63 10.5 0.1 2.8 2 1 0 2 2 2 0 AAA domain RNA12 PF10443.9 EDO16508.1 - 4.2e-170 566.3 2.7 4.2e-170 566.3 2.7 1.8 2 0 0 2 2 2 1 RNA12 protein RRM_1 PF00076.22 EDO16508.1 - 8.8e-06 25.5 0.0 2.3e-05 24.1 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) ATPase_2 PF01637.18 EDO16508.1 - 6.4e-05 23.0 2.7 0.00042 20.3 1.0 2.8 1 1 1 2 2 2 1 ATPase domain predominantly from Archaea AAA_14 PF13173.6 EDO16508.1 - 0.033 14.2 1.4 0.084 12.9 0.0 2.5 3 0 0 3 3 3 0 AAA domain Cytochrom_B559a PF00284.20 EDO16508.1 - 0.16 11.7 0.0 0.41 10.4 0.0 1.7 1 0 0 1 1 1 0 Lumenal portion of Cytochrome b559, alpha (gene psbE) subunit Cnd1 PF12717.7 EDO16508.1 - 0.25 11.4 1.7 0.8 9.7 1.7 1.9 1 1 1 2 2 2 0 non-SMC mitotic condensation complex subunit 1 USP7_C2 PF14533.6 EDO16509.1 - 7.6e-61 205.4 6.6 5.3e-58 196.1 5.0 2.8 2 0 0 2 2 2 2 Ubiquitin-specific protease C-terminal UCH PF00443.29 EDO16509.1 - 4.6e-45 154.1 1.6 9.2e-45 153.1 1.6 1.5 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase USP7_ICP0_bdg PF12436.8 EDO16509.1 - 2.4e-34 118.7 4.3 2.6e-32 112.1 0.4 2.8 3 0 0 3 3 3 2 ICP0-binding domain of Ubiquitin-specific protease 7 UCH_1 PF13423.6 EDO16509.1 - 1.5e-20 74.0 0.1 1.7e-19 70.6 0.1 2.2 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase MATH PF00917.26 EDO16509.1 - 7e-05 23.0 0.8 0.00025 21.2 0.1 2.4 2 0 0 2 2 2 1 MATH domain UN_NPL4 PF11543.8 EDO16509.1 - 0.00066 20.1 1.5 0.46 11.0 0.2 4.6 5 1 0 5 5 5 1 Nuclear pore localisation protein NPL4 Glyco_hydro_17 PF00332.18 EDO16510.1 - 1.9e-08 34.3 10.8 2.4e-08 34.0 3.6 3.0 2 1 0 2 2 2 1 Glycosyl hydrolases family 17 DUF5423 PF17461.2 EDO16510.1 - 0.15 10.9 9.8 0.23 10.3 9.8 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5423) Mucin PF01456.17 EDO16510.1 - 1.6 8.7 19.1 3.6 7.6 19.1 1.6 1 0 0 1 1 1 0 Mucin-like glycoprotein Importin_rep_6 PF18829.1 EDO16511.1 - 2.5e-47 159.5 2.0 2.5e-47 159.5 2.0 3.8 3 0 0 3 3 3 1 Importin repeat 6 Importin_rep_4 PF18808.1 EDO16511.1 - 3.1e-31 107.5 1.2 3.1e-31 107.5 1.2 3.9 4 1 1 5 5 3 1 Importin repeat Importin_rep_5 PF18816.1 EDO16511.1 - 2.2e-26 91.9 0.7 5.5e-25 87.4 0.0 2.9 2 0 0 2 2 2 1 Importin repeat HEAT_EZ PF13513.6 EDO16511.1 - 5.3e-22 77.9 8.0 1.5e-11 44.5 0.0 8.4 8 1 1 9 9 9 3 HEAT-like repeat HEAT_2 PF13646.6 EDO16511.1 - 4.9e-17 62.1 1.2 1e-05 25.8 0.0 7.0 5 1 2 7 7 6 4 HEAT repeats HEAT PF02985.22 EDO16511.1 - 4.7e-15 54.4 8.4 0.0036 17.4 0.0 10.3 11 0 0 11 11 10 1 HEAT repeat RIX1 PF08167.12 EDO16511.1 - 1.4e-09 38.0 5.9 6e-06 26.1 1.2 4.8 4 1 1 5 5 5 2 rRNA processing/ribosome biogenesis Adaptin_N PF01602.20 EDO16511.1 - 3.8e-07 29.0 3.3 0.091 11.3 0.0 4.4 3 1 1 4 4 4 2 Adaptin N terminal region Cnd1 PF12717.7 EDO16511.1 - 1.1e-06 28.8 3.9 0.71 9.9 0.0 5.9 3 2 3 6 6 6 1 non-SMC mitotic condensation complex subunit 1 MMS19_C PF12460.8 EDO16511.1 - 1.1e-06 28.1 17.8 0.0016 17.6 6.0 4.8 3 2 1 4 4 4 3 RNAPII transcription regulator C-terminal Vac14_Fab1_bd PF12755.7 EDO16511.1 - 5.3e-06 27.0 0.3 0.29 11.7 0.0 5.9 5 1 3 8 8 6 1 Vacuolar 14 Fab1-binding region CLASP_N PF12348.8 EDO16511.1 - 2.6e-05 23.9 0.7 0.0083 15.7 0.2 4.4 4 1 0 4 4 4 1 CLASP N terminal DUF3385 PF11865.8 EDO16511.1 - 0.00011 22.2 6.8 0.01 15.8 0.3 5.7 4 3 1 6 6 6 1 Domain of unknown function (DUF3385) Arm PF00514.23 EDO16511.1 - 0.00018 21.4 12.2 1.1 9.4 0.1 6.7 9 0 0 9 9 8 2 Armadillo/beta-catenin-like repeat RTP1_C1 PF10363.9 EDO16511.1 - 0.00035 20.7 1.4 8.3 6.6 0.1 5.5 5 0 0 5 5 5 1 Required for nuclear transport of RNA pol II C-terminus 1 IFRD PF05004.13 EDO16511.1 - 0.00039 19.6 8.4 0.0049 16.0 0.6 3.8 4 0 0 4 4 4 1 Interferon-related developmental regulator (IFRD) DNA_alkylation PF08713.11 EDO16511.1 - 0.0025 17.5 0.0 0.04 13.6 0.0 2.9 3 0 0 3 3 3 1 DNA alkylation repair enzyme V-ATPase_H_N PF03224.14 EDO16511.1 - 0.017 14.4 5.5 0.076 12.3 0.9 3.2 3 0 0 3 3 3 0 V-ATPase subunit H eIF-3c_N PF05470.12 EDO16512.1 - 4.3e-158 527.3 19.7 4.6e-124 414.9 5.5 2.4 1 1 1 2 2 2 2 Eukaryotic translation initiation factor 3 subunit 8 N-terminus PCI PF01399.27 EDO16512.1 - 5.4e-11 42.9 2.5 2.8e-10 40.6 0.3 3.2 2 1 0 2 2 2 1 PCI domain Ribosomal_L27_C PF18471.1 EDO16512.1 - 0.0019 17.7 2.9 0.0019 17.7 2.9 2.8 3 0 0 3 3 3 1 Ribosomal L27 protein C-terminal domain IPP-2 PF04979.14 EDO16513.1 - 4.5e-22 79.2 17.6 4.5e-22 79.2 17.6 2.0 2 0 0 2 2 2 1 Protein phosphatase inhibitor 2 (IPP-2) PEHE PF15275.6 EDO16513.1 - 5 7.8 14.2 0.23 12.1 7.7 2.0 2 1 0 2 2 2 0 PEHE domain SURF4 PF02077.15 EDO16514.1 - 1.2e-102 343.2 14.1 1.3e-102 343.0 14.1 1.0 1 0 0 1 1 1 1 SURF4 family OST3_OST6 PF04756.13 EDO16515.1 - 2.4e-10 40.3 0.0 2.9e-10 40.0 0.0 1.1 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin PF00085.20 EDO16515.1 - 0.00063 19.7 0.0 0.00093 19.2 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin DUF3336 PF11815.8 EDO16516.1 - 1.1e-26 93.2 0.1 2.1e-26 92.3 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3336) Patatin PF01734.22 EDO16516.1 - 1.1e-07 32.2 0.0 1.9e-07 31.5 0.0 1.5 1 0 0 1 1 1 1 Patatin-like phospholipase MFS_1 PF07690.16 EDO16517.1 - 5.5e-09 35.4 37.3 3.5e-08 32.7 31.8 2.4 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EDO16517.1 - 5.7e-07 28.7 6.1 5.7e-07 28.7 6.1 2.6 3 0 0 3 3 3 2 Sugar (and other) transporter UPF0730 PF15827.5 EDO16517.1 - 0.071 12.9 0.1 0.14 11.9 0.1 1.4 1 0 0 1 1 1 0 UPF0730 unknown protein family adh_short PF00106.25 EDO16518.1 - 2.2e-20 72.9 0.2 5.7e-20 71.6 0.1 1.6 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 EDO16518.1 - 1.8e-11 44.1 0.0 2.8e-11 43.4 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EDO16518.1 - 4.5e-10 39.7 0.0 6.7e-10 39.2 0.0 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EDO16518.1 - 0.0015 18.1 0.0 0.002 17.6 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EDO16518.1 - 0.048 13.1 0.0 0.059 12.8 0.0 1.3 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase ADH_zinc_N PF00107.26 EDO16518.1 - 0.096 12.7 0.0 0.17 11.8 0.0 1.4 1 0 0 1 1 1 0 Zinc-binding dehydrogenase Ntox30 PF15532.6 EDO16519.1 - 0.15 12.5 0.8 32 5.0 0.0 3.3 3 0 0 3 3 3 0 Bacterial toxin 30 DUF3796 PF12676.7 EDO16520.1 - 1.2 9.6 8.0 3.4 8.1 1.7 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3796) dsrm PF00035.26 EDO16521.1 - 1.4e-07 32.2 0.0 2.7e-07 31.2 0.0 1.5 1 0 0 1 1 1 1 Double-stranded RNA binding motif Ribonuclease_3 PF00636.26 EDO16521.1 - 1.2e-05 25.9 0.2 9e-05 23.0 0.0 2.4 2 1 0 2 2 2 1 Ribonuclease III domain Pex2_Pex12 PF04757.14 EDO16523.1 - 3e-42 144.7 14.4 3.7e-42 144.4 14.4 1.1 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-C3HC4_3 PF13920.6 EDO16523.1 - 7.9e-07 28.8 3.0 1.3e-06 28.2 3.0 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EDO16523.1 - 1.7e-05 24.5 4.6 2.7e-05 23.9 4.6 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EDO16523.1 - 0.0045 17.1 6.6 0.0078 16.3 6.6 1.4 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.25 EDO16523.1 - 0.042 13.7 4.3 0.072 13.0 4.3 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EDO16523.1 - 0.17 11.9 7.1 0.34 11.0 7.1 1.5 1 0 0 1 1 1 0 RING-type zinc-finger zf-RING_2 PF13639.6 EDO16523.1 - 0.23 11.8 3.7 0.41 11.0 3.7 1.4 1 0 0 1 1 1 0 Ring finger domain F_bP_aldolase PF01116.20 EDO16524.1 - 1.4e-89 300.3 0.0 1.6e-89 300.1 0.0 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-II DUF89 PF01937.19 EDO16525.1 - 9.1e-110 366.9 6.1 1e-109 366.7 6.1 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF89 DWNN PF08783.11 EDO16526.1 - 3e-31 107.5 1.4 9.7e-30 102.7 0.1 2.5 2 0 0 2 2 2 1 DWNN domain U-box PF04564.15 EDO16526.1 - 1.5e-07 31.5 0.0 5.1e-07 29.8 0.0 2.0 1 0 0 1 1 1 1 U-box domain zf-CCHC_2 PF13696.6 EDO16526.1 - 1.2e-06 28.2 6.1 2.4e-06 27.2 6.1 1.6 1 0 0 1 1 1 1 Zinc knuckle zf-Nse PF11789.8 EDO16526.1 - 4.2e-06 26.5 0.5 1.1e-05 25.1 0.5 1.7 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-CCHC PF00098.23 EDO16526.1 - 0.0041 17.1 2.7 0.0079 16.2 2.7 1.4 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_5 PF14787.6 EDO16526.1 - 0.042 13.6 0.5 0.097 12.4 0.5 1.6 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger zf-CCHC_3 PF13917.6 EDO16526.1 - 0.1 12.6 0.1 0.2 11.7 0.1 1.5 1 0 0 1 1 1 0 Zinc knuckle zf-DNL PF05180.12 EDO16526.1 - 0.28 11.2 1.8 0.28 11.2 0.2 1.8 2 0 0 2 2 2 0 DNL zinc finger zf-C3HC4_2 PF13923.6 EDO16526.1 - 1.1 9.1 5.0 0.18 11.7 0.5 1.9 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Rubredoxin PF00301.20 EDO16526.1 - 1.3 9.1 6.0 3.1 7.9 0.0 3.2 4 0 0 4 4 4 0 Rubredoxin TFIIA_gamma_C PF02751.14 EDO16527.1 - 2.1e-22 79.0 0.3 3.5e-22 78.3 0.3 1.4 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit TFIIA_gamma_N PF02268.16 EDO16527.1 - 7.4e-22 77.1 0.1 1.1e-21 76.5 0.1 1.3 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit, helical domain TAP42 PF04177.12 EDO16528.1 - 1.2e-82 277.6 17.0 1.4e-82 277.4 17.0 1.0 1 0 0 1 1 1 1 TAP42-like family TCTP PF00838.17 EDO16529.1 - 2.2e-71 239.5 0.4 2.5e-71 239.4 0.4 1.0 1 0 0 1 1 1 1 Translationally controlled tumour protein adh_short PF00106.25 EDO16530.1 - 1.5e-28 99.6 0.0 2.4e-21 76.1 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EDO16530.1 - 8e-14 51.7 0.0 1.8e-11 44.1 0.0 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase NYD-SP28_assoc PF14775.6 EDO16530.1 - 0.0029 17.7 0.2 0.25 11.5 0.0 2.9 3 0 0 3 3 3 1 Sperm tail C-terminal domain Epimerase PF01370.21 EDO16530.1 - 0.15 11.5 0.0 0.29 10.5 0.0 1.5 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family WYL_3 PF18488.1 EDO16530.1 - 0.15 12.4 1.5 0.35 11.3 0.0 2.4 3 0 0 3 3 3 0 WYL domain UPF0203 PF05254.12 EDO16531.1 - 9.4e-28 96.3 4.4 1.1e-27 96.0 4.4 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0203) UCR_hinge PF02320.16 EDO16531.1 - 0.0031 17.7 2.7 0.0052 17.0 2.7 1.4 1 1 0 1 1 1 1 Ubiquinol-cytochrome C reductase hinge protein Cmc1 PF08583.10 EDO16531.1 - 0.007 16.4 2.9 0.047 13.7 1.4 2.1 1 1 1 2 2 2 1 Cytochrome c oxidase biogenesis protein Cmc1 like CX9C PF16860.5 EDO16531.1 - 0.033 14.2 1.4 0.49 10.5 0.2 2.1 2 0 0 2 2 2 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, DUF3128 PF11326.8 EDO16531.1 - 0.06 13.7 2.3 0.8 10.1 2.3 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF3128) COX17 PF05051.13 EDO16531.1 - 0.07 13.5 0.9 0.2 12.1 0.9 1.6 1 1 0 1 1 1 0 Cytochrome C oxidase copper chaperone (COX17) Pet191_N PF10203.9 EDO16531.1 - 0.11 12.8 3.1 6.8 7.1 0.2 2.1 1 1 1 2 2 2 0 Cytochrome c oxidase assembly protein PET191 DASH_Ask1 PF08655.10 EDO16532.1 - 2.3e-28 97.9 0.3 4e-28 97.1 0.3 1.4 1 0 0 1 1 1 1 DASH complex subunit Ask1 Frag1 PF10277.9 EDO16533.1 - 3.1e-84 281.9 24.5 3.7e-84 281.6 24.5 1.0 1 0 0 1 1 1 1 Frag1/DRAM/Sfk1 family FCH PF00611.23 EDO16534.1 - 3.5e-12 46.4 0.0 2.3e-11 43.8 0.0 2.5 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain SH3_2 PF07653.17 EDO16534.1 - 0.0012 18.5 0.0 0.0025 17.5 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EDO16534.1 - 0.0036 16.9 0.0 0.0072 15.9 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EDO16534.1 - 0.015 15.2 0.0 0.03 14.2 0.0 1.5 1 0 0 1 1 1 0 Variant SH3 domain SNCAIP_SNCA_bd PF16700.5 EDO16534.1 - 0.14 11.9 0.9 0.33 10.7 0.2 2.0 2 0 0 2 2 2 0 Synphilin-1 alpha-Synuclein-binding domain DUF4407 PF14362.6 EDO16534.1 - 2.9 7.1 9.8 1.1 8.5 6.7 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) TPR_MLP1_2 PF07926.12 EDO16534.1 - 5.5 7.1 12.9 3 7.9 5.9 2.8 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein HCMV_UL139 PF12507.8 EDO16534.1 - 7.8 6.9 7.5 64 3.9 0.2 4.2 4 1 0 5 5 5 0 Human Cytomegalovirus UL139 protein Cyt-b5 PF00173.28 EDO16535.1 - 2.8e-13 49.8 0.0 3.8e-13 49.4 0.0 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain TFR_dimer PF04253.15 EDO16536.1 - 1.8e-28 99.1 0.3 3.4e-28 98.2 0.3 1.5 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain Peptidase_M28 PF04389.17 EDO16536.1 - 4.5e-05 23.2 0.0 9.2e-05 22.2 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M28 PIGA PF08288.12 EDO16537.1 - 5.7e-43 145.4 0.2 1.8e-42 143.8 0.2 1.9 1 0 0 1 1 1 1 PIGA (GPI anchor biosynthesis) Glyco_transf_4 PF13439.6 EDO16537.1 - 4.5e-33 114.7 0.2 1.1e-32 113.4 0.2 1.7 2 0 0 2 2 2 1 Glycosyltransferase Family 4 Glycos_transf_1 PF00534.20 EDO16537.1 - 3.8e-26 91.6 0.0 6.8e-26 90.8 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 EDO16537.1 - 2.7e-21 76.4 0.0 5.5e-21 75.4 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 EDO16537.1 - 1.7e-14 54.5 0.0 3e-14 53.8 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_trans_4_2 PF13477.6 EDO16537.1 - 9.1e-06 25.7 0.1 3.7e-05 23.8 0.0 1.9 2 0 0 2 2 2 1 Glycosyl transferase 4-like Glyco_trans_1_2 PF13524.6 EDO16537.1 - 0.0018 18.6 0.0 0.0041 17.5 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferases group 1 Asparaginase_C PF17763.1 EDO16537.1 - 0.12 12.6 0.1 40 4.5 0.0 2.9 3 0 0 3 3 3 0 Glutaminase/Asparaginase C-terminal domain EF-hand_1 PF00036.32 EDO16538.1 - 6.5e-26 87.9 14.3 1.1e-07 30.8 1.7 4.2 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 EDO16538.1 - 8.3e-26 90.2 11.4 7.4e-15 55.2 2.7 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EDO16538.1 - 2e-21 74.0 11.5 1.3e-06 27.8 0.1 4.3 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 EDO16538.1 - 1.4e-17 63.3 11.1 4.4e-11 42.5 0.8 4.0 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.6 EDO16538.1 - 1.6e-12 46.3 9.8 0.00055 19.3 0.0 4.1 4 0 0 4 4 4 3 EF hand EF-hand_9 PF14658.6 EDO16538.1 - 6.5e-08 32.8 0.8 0.0092 16.3 0.1 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 EDO16538.1 - 2.5e-06 27.4 2.9 0.0018 18.2 0.0 2.6 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 EDO16538.1 - 0.0011 19.2 0.2 0.25 11.7 0.0 2.1 2 0 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region DUF1296 PF06972.11 EDO16538.1 - 0.024 14.8 0.3 8.2 6.6 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1296) Caleosin PF05042.13 EDO16538.1 - 0.04 13.9 1.1 1.7 8.5 0.0 3.2 1 1 3 4 4 4 0 Caleosin related protein PhetRS_B1 PF18262.1 EDO16538.1 - 0.046 13.9 0.6 0.12 12.6 0.6 1.8 1 0 0 1 1 1 0 Phe-tRNA synthetase beta subunit B1 domain EF-hand_14 PF17959.1 EDO16538.1 - 0.077 13.3 0.6 0.83 10.0 0.1 2.1 2 0 0 2 2 2 0 EF-hand domain SUB1_ProdP9 PF18213.1 EDO16538.1 - 0.084 12.7 0.2 0.18 11.7 0.2 1.6 1 0 0 1 1 1 0 SUB1 protease Prodomain ProdP9 FliX PF10768.9 EDO16538.1 - 0.44 11.1 2.2 0.24 11.9 0.3 1.6 2 0 0 2 2 1 0 Class II flagellar assembly regulator VCBS PF13517.6 EDO16538.1 - 0.5 11.0 5.2 1.3 9.7 0.0 2.7 3 1 0 3 3 3 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella HIT PF01230.23 EDO16540.1 - 1.1e-18 67.7 0.6 9.5e-18 64.7 0.4 2.0 2 0 0 2 2 2 1 HIT domain zf-C2HE PF16278.5 EDO16540.1 - 7.3e-17 61.6 1.3 1.9e-16 60.2 1.3 1.7 1 0 0 1 1 1 1 C2HE / C2H2 / C2HC zinc-binding finger DcpS_C PF11969.8 EDO16540.1 - 3.2e-15 56.6 8.3 1.3e-14 54.7 8.3 1.8 1 1 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding zf-C2H2_4 PF13894.6 EDO16540.1 - 0.015 16.1 1.7 0.015 16.1 1.7 3.4 4 2 1 5 5 5 0 C2H2-type zinc finger zf-BED PF02892.15 EDO16540.1 - 0.017 15.1 0.1 0.045 13.8 0.1 1.7 1 0 0 1 1 1 0 BED zinc finger zf-C2H2 PF00096.26 EDO16540.1 - 3.6 8.2 8.3 0.27 11.8 0.6 3.1 3 0 0 3 3 3 0 Zinc finger, C2H2 type AAA PF00004.29 EDO16541.1 - 1.5e-42 145.1 0.0 2.8e-42 144.3 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EDO16541.1 - 3.4e-08 33.1 0.5 8.9e-08 31.8 0.0 2.0 2 0 0 2 2 2 1 AAA+ lid domain Prot_ATP_ID_OB PF16450.5 EDO16541.1 - 6.6e-08 32.4 0.9 9e-08 32.0 0.1 1.7 2 0 0 2 2 1 1 Proteasomal ATPase OB C-terminal domain AAA_16 PF13191.6 EDO16541.1 - 3.2e-07 30.9 0.0 8.8e-05 22.9 0.0 2.5 1 1 1 2 2 2 1 AAA ATPase domain AAA_5 PF07728.14 EDO16541.1 - 9.3e-07 28.9 1.0 4.1e-05 23.6 0.2 3.1 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 EDO16541.1 - 2.1e-05 24.7 0.0 8.2e-05 22.8 0.0 2.0 2 0 0 2 2 1 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 EDO16541.1 - 5.4e-05 23.0 0.0 0.00014 21.7 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain TsaE PF02367.17 EDO16541.1 - 0.00017 21.6 0.0 0.00032 20.7 0.0 1.4 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_22 PF13401.6 EDO16541.1 - 0.002 18.4 0.2 0.031 14.6 0.1 2.3 1 1 1 2 2 2 1 AAA domain TIP49 PF06068.13 EDO16541.1 - 0.0021 17.3 0.1 0.0049 16.1 0.1 1.6 1 0 0 1 1 1 1 TIP49 P-loop domain RNA_helicase PF00910.22 EDO16541.1 - 0.0023 18.3 0.0 0.0049 17.2 0.0 1.6 1 0 0 1 1 1 1 RNA helicase Mg_chelatase PF01078.21 EDO16541.1 - 0.0063 15.9 0.1 0.012 15.0 0.1 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_33 PF13671.6 EDO16541.1 - 0.0086 16.2 0.1 0.023 14.9 0.0 1.8 2 0 0 2 2 1 1 AAA domain AAA_18 PF13238.6 EDO16541.1 - 0.0088 16.6 0.0 0.032 14.8 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.6 EDO16541.1 - 0.013 15.2 0.0 0.037 13.7 0.0 1.8 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 EDO16541.1 - 0.014 15.2 0.0 0.03 14.1 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein Prot_ATP_OB_N PF17758.1 EDO16541.1 - 0.019 14.6 0.1 0.063 12.9 0.0 1.8 2 0 0 2 2 2 0 Proteasomal ATPase OB N-terminal domain AAA_28 PF13521.6 EDO16541.1 - 0.023 15.0 0.2 0.066 13.5 0.0 1.9 2 0 0 2 2 2 0 AAA domain Phage_GP20 PF06810.11 EDO16541.1 - 0.046 13.5 5.9 1.2 8.9 6.0 2.4 2 0 0 2 2 2 0 Phage minor structural protein GP20 AAA_7 PF12775.7 EDO16541.1 - 0.046 13.2 0.0 0.13 11.8 0.0 1.7 1 1 0 1 1 1 0 P-loop containing dynein motor region AAA_14 PF13173.6 EDO16541.1 - 0.05 13.6 0.0 0.14 12.2 0.0 1.7 2 0 0 2 2 1 0 AAA domain AAA_25 PF13481.6 EDO16541.1 - 0.051 13.1 0.6 0.19 11.3 0.1 2.1 2 0 0 2 2 2 0 AAA domain Fib_alpha PF08702.10 EDO16541.1 - 0.068 13.4 1.0 0.17 12.1 1.0 1.7 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family Parvo_NS1 PF01057.17 EDO16541.1 - 0.079 12.0 0.1 0.16 11.0 0.1 1.4 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 PhoH PF02562.16 EDO16541.1 - 0.099 12.1 1.9 0.12 11.8 0.2 1.9 2 0 0 2 2 2 0 PhoH-like protein ATPase PF06745.13 EDO16541.1 - 0.1 11.9 2.8 0.1 11.9 0.0 2.3 3 0 0 3 3 3 0 KaiC AAA_3 PF07726.11 EDO16541.1 - 0.1 12.4 0.0 0.23 11.3 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 EDO16541.1 - 0.16 11.8 0.1 0.5 10.3 0.0 1.8 2 0 0 2 2 2 0 NACHT domain AAA_11 PF13086.6 EDO16541.1 - 0.17 11.7 2.0 0.94 9.2 0.0 2.2 2 0 0 2 2 2 0 AAA domain Hexapep PF00132.24 EDO16542.1 - 1.9e-07 30.5 1.7 0.00097 18.8 0.2 3.5 1 1 2 3 3 3 3 Bacterial transferase hexapeptide (six repeats) Fucokinase PF07959.12 EDO16542.1 - 1.9e-05 23.8 1.5 5.2e-05 22.4 1.3 1.6 1 1 0 1 1 1 1 L-fucokinase NTP_transf_3 PF12804.7 EDO16542.1 - 4.1e-05 24.0 0.0 7.5e-05 23.1 0.0 1.5 1 1 0 1 1 1 1 MobA-like NTP transferase domain DUF4954 PF16314.5 EDO16542.1 - 0.00022 19.5 0.3 0.00051 18.3 0.3 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF4954) Tox-GHH PF15636.6 EDO16542.1 - 0.039 13.9 0.0 0.12 12.4 0.0 1.8 1 0 0 1 1 1 0 GHH signature containing HNH/Endo VII superfamily nuclease toxin Hexapep_2 PF14602.6 EDO16542.1 - 0.14 11.9 3.6 0.36 10.6 1.3 2.5 2 0 0 2 2 2 0 Hexapeptide repeat of succinyl-transferase UbiA PF01040.18 EDO16543.1 - 1.5e-48 165.3 7.8 2.8e-48 164.4 7.8 1.3 1 0 0 1 1 1 1 UbiA prenyltransferase family MitMem_reg PF13012.6 EDO16544.1 - 7.6e-34 116.5 0.3 1.6e-33 115.5 0.3 1.6 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function JAB PF01398.21 EDO16544.1 - 4.3e-30 104.1 1.0 6.9e-30 103.5 0.0 1.8 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease KilA-N PF04383.13 EDO16544.1 - 0.76 9.7 0.0 0.76 9.7 0.0 2.3 2 0 0 2 2 2 0 KilA-N domain ATP_bind_1 PF03029.17 EDO16545.1 - 1.1e-80 271.0 0.1 1.5e-80 270.5 0.1 1.2 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein AAA_17 PF13207.6 EDO16545.1 - 0.0042 17.5 2.1 0.3 11.5 0.1 2.3 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 EDO16545.1 - 0.0054 17.3 0.7 0.28 11.7 0.1 2.7 2 1 0 2 2 2 1 AAA domain MeaB PF03308.16 EDO16545.1 - 0.026 13.5 0.1 0.059 12.3 0.0 1.5 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB CLP1_P PF16575.5 EDO16545.1 - 0.042 13.7 0.0 0.071 12.9 0.0 1.4 1 0 0 1 1 1 0 mRNA cleavage and polyadenylation factor CLP1 P-loop RNA_helicase PF00910.22 EDO16545.1 - 0.054 13.9 0.0 0.13 12.6 0.0 1.7 1 0 0 1 1 1 0 RNA helicase AAA_22 PF13401.6 EDO16545.1 - 0.06 13.6 0.0 0.13 12.5 0.0 1.8 1 1 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 EDO16545.1 - 0.077 13.1 0.0 0.96 9.6 0.0 2.4 1 1 0 1 1 1 0 50S ribosome-binding GTPase Glutaredoxin PF00462.24 EDO16545.1 - 0.17 12.1 0.3 0.75 10.1 0.3 2.1 1 0 0 1 1 1 0 Glutaredoxin CdiI_2 PF18593.1 EDO16546.1 - 0.18 12.5 0.1 0.44 11.2 0.1 1.6 1 0 0 1 1 1 0 CdiI immunity protein TBCA PF02970.16 EDO16547.1 - 6.8e-24 84.0 7.0 8.2e-24 83.8 7.0 1.2 1 0 0 1 1 1 1 Tubulin binding cofactor A DUF1400 PF07176.11 EDO16547.1 - 0.016 15.5 1.1 3.2 8.0 0.5 2.1 1 1 1 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF1400) NusB PF01029.18 EDO16547.1 - 0.12 12.6 1.6 0.15 12.3 1.6 1.1 1 0 0 1 1 1 0 NusB family Phage_sheath_1C PF17482.2 EDO16547.1 - 0.14 12.1 1.4 10 6.1 0.1 2.1 1 1 0 2 2 2 0 Phage tail sheath C-terminal domain FapA PF03961.13 EDO16547.1 - 0.39 9.3 4.5 0.42 9.2 4.5 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A Pkinase PF00069.25 EDO16549.1 - 3.8e-43 147.8 0.3 6.7e-43 147.0 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO16549.1 - 2.4e-21 76.2 0.0 3.5e-21 75.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EDO16549.1 - 0.0015 18.5 0.0 0.0026 17.7 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.22 EDO16549.1 - 0.013 15.1 0.0 0.027 14.1 0.0 1.5 1 0 0 1 1 1 0 RIO1 family Kinase-like PF14531.6 EDO16549.1 - 0.014 14.7 0.1 0.074 12.4 0.0 2.0 2 1 1 3 3 3 0 Kinase-like V_ATPase_I PF01496.19 EDO16550.1 - 0 1022.0 3.5 0 1021.6 3.5 1.1 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family GIT_CC PF16559.5 EDO16550.1 - 0.17 11.8 2.3 0.19 11.6 0.3 2.1 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor THP2 PF09432.10 EDO16550.1 - 0.59 10.2 6.7 0.61 10.1 1.6 2.8 2 1 0 2 2 2 0 Tho complex subunit THP2 7TM_GPCR_Srt PF10321.9 EDO16550.1 - 1 8.3 16.7 0.024 13.6 0.6 3.2 3 0 0 3 3 3 0 Serpentine type 7TM GPCR chemoreceptor Srt GHMP_kinases_N PF00288.26 EDO16551.1 - 1.2e-18 67.1 0.8 2.3e-18 66.2 0.8 1.5 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 EDO16551.1 - 2.9e-06 27.5 0.0 8.8e-06 26.0 0.0 1.8 1 0 0 1 1 1 1 GHMP kinases C terminal GalKase_gal_bdg PF10509.9 EDO16551.1 - 0.16 11.5 0.0 0.34 10.5 0.0 1.4 1 0 0 1 1 1 0 Galactokinase galactose-binding signature Mtc PF03820.17 EDO16552.1 - 8.2e-124 412.7 0.6 9.2e-124 412.5 0.6 1.0 1 0 0 1 1 1 1 Tricarboxylate carrier GTP_EFTU_D4 PF14578.6 EDO16552.1 - 0.078 12.9 0.2 15 5.6 0.0 2.5 2 0 0 2 2 2 0 Elongation factor Tu domain 4 WD40 PF00400.32 EDO16553.1 - 5.5e-27 93.5 13.1 7.8e-07 29.7 0.1 6.9 7 0 0 7 7 7 5 WD domain, G-beta repeat NLE PF08154.12 EDO16553.1 - 2.3e-22 79.3 0.2 5.6e-22 78.0 0.1 1.8 2 0 0 2 2 2 1 NLE (NUC135) domain Nup160 PF11715.8 EDO16553.1 - 6.1e-08 31.8 3.3 0.0025 16.5 0.2 3.1 3 1 0 3 3 3 2 Nucleoporin Nup120/160 WD40_like PF17005.5 EDO16553.1 - 0.0051 16.2 1.0 0.1 11.9 1.0 3.1 1 1 0 1 1 1 1 WD40-like domain ANAPC4_WD40 PF12894.7 EDO16553.1 - 0.017 15.4 0.1 0.088 13.1 0.0 2.3 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain FAM117 PF15388.6 EDO16553.1 - 0.15 11.4 0.0 0.36 10.2 0.0 1.6 1 1 0 1 1 1 0 Protein Family FAM117 Abhydrolase_1 PF00561.20 EDO16554.1 - 1.1e-13 51.4 0.1 1.3e-12 47.9 0.1 2.1 2 0 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EDO16554.1 - 8.3e-07 28.5 0.0 1.6e-06 27.6 0.0 1.5 2 0 0 2 2 2 1 Serine aminopeptidase, S33 DUF915 PF06028.11 EDO16554.1 - 0.00027 20.3 0.0 0.00063 19.2 0.0 1.6 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF915) Lipase_3 PF01764.25 EDO16554.1 - 0.004 17.0 0.0 0.0074 16.1 0.0 1.4 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_6 PF12697.7 EDO16554.1 - 0.013 16.1 0.0 0.019 15.6 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family Cutinase PF01083.22 EDO16554.1 - 0.037 14.0 0.0 0.061 13.3 0.0 1.3 1 0 0 1 1 1 0 Cutinase Tubulin_3 PF14881.6 EDO16555.1 - 6.9e-29 100.8 0.1 1.4e-28 99.8 0.1 1.5 1 0 0 1 1 1 1 Tubulin domain Misat_Tub_SegII PF10644.9 EDO16555.1 - 3e-19 69.5 0.5 6.8e-19 68.3 0.5 1.6 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin PF00091.25 EDO16555.1 - 4.2e-05 23.8 0.0 0.13 12.4 0.0 2.4 2 0 0 2 2 2 2 Tubulin/FtsZ family, GTPase domain Arm_3 PF16186.5 EDO16555.1 - 3.2 7.4 8.4 3.7 7.2 0.0 4.0 4 0 0 4 4 4 0 Atypical Arm repeat IPPT PF01715.17 EDO16556.1 - 3.2e-66 223.4 1.1 6.3e-66 222.5 1.1 1.4 1 0 0 1 1 1 1 IPP transferase AAA_33 PF13671.6 EDO16556.1 - 3.5e-05 24.0 0.0 0.00035 20.8 0.0 2.6 3 0 0 3 3 3 1 AAA domain AAA_18 PF13238.6 EDO16556.1 - 0.00017 22.1 2.1 0.0029 18.2 0.1 2.9 3 1 0 3 3 3 1 AAA domain IPT PF01745.16 EDO16556.1 - 0.00021 20.8 0.1 0.0022 17.4 0.0 2.6 2 1 1 3 3 3 1 Isopentenyl transferase AAA_25 PF13481.6 EDO16556.1 - 0.017 14.7 0.1 0.034 13.7 0.1 1.4 1 0 0 1 1 1 0 AAA domain SKI PF01202.22 EDO16556.1 - 0.021 15.0 0.4 11 6.1 0.0 3.1 3 0 0 3 3 3 0 Shikimate kinase Hydin_ADK PF17213.3 EDO16556.1 - 0.031 14.6 0.0 0.37 11.0 0.0 2.3 2 0 0 2 2 2 0 Hydin Adenylate kinase-like domain RsgA_GTPase PF03193.16 EDO16556.1 - 0.04 13.8 1.1 0.31 10.9 1.1 2.3 1 1 0 1 1 1 0 RsgA GTPase DnaB_C PF03796.15 EDO16556.1 - 0.055 12.8 0.0 0.11 11.8 0.0 1.5 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain CbiA PF01656.23 EDO16556.1 - 0.07 13.2 0.7 0.13 12.3 0.6 1.7 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_7 PF12775.7 EDO16556.1 - 0.079 12.5 0.3 0.17 11.4 0.3 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region RNA_helicase PF00910.22 EDO16556.1 - 0.092 13.1 0.0 0.29 11.5 0.0 1.9 1 0 0 1 1 1 0 RNA helicase ABC_tran PF00005.27 EDO16556.1 - 1.2 9.6 3.6 1.3 9.5 2.0 2.1 2 1 0 2 2 2 0 ABC transporter PUF PF00806.19 EDO16557.1 - 0.0002 20.9 0.3 0.0002 20.9 0.3 2.9 3 0 0 3 3 3 1 Pumilio-family RNA binding repeat Rtt106_N PF18215.1 EDO16557.1 - 0.045 13.5 0.0 0.15 11.8 0.0 1.9 1 0 0 1 1 1 0 Histone chaperone Rtt106 N-terminal domain PGG PF13962.6 EDO16557.1 - 0.28 11.0 1.8 1.8 8.4 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function DnaJ PF00226.31 EDO16558.1 - 1.2e-27 95.7 1.9 1.9e-27 95.1 1.9 1.3 1 0 0 1 1 1 1 DnaJ domain DnaJ_C PF01556.18 EDO16558.1 - 6.3e-22 78.3 0.1 8.1e-22 77.9 0.1 1.1 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.19 EDO16558.1 - 5.2e-15 55.6 17.0 9.1e-15 54.8 17.0 1.4 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 EDO16558.1 - 2.4e-07 30.6 8.4 0.00023 21.0 1.5 2.3 2 0 0 2 2 2 2 Tryptophan RNA-binding attenuator protein inhibitory protein HypA PF01155.19 EDO16558.1 - 0.069 13.2 11.9 0.76 9.8 3.0 2.3 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Lar_restr_allev PF14354.6 EDO16558.1 - 2.8 8.4 9.6 1.8 9.0 4.4 2.9 2 1 0 2 2 2 0 Restriction alleviation protein Lar Glyco_hydro_72 PF03198.14 EDO16559.1 - 2.2e-126 421.4 4.3 8.5e-126 419.5 4.4 1.7 2 0 0 2 2 2 1 Glucanosyltransferase Glyco_hydro_2_C PF02836.17 EDO16559.1 - 1.6e-07 30.7 0.1 2.6e-07 30.0 0.1 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Cellulase PF00150.18 EDO16559.1 - 0.029 13.8 0.1 0.12 11.8 0.1 2.0 1 1 0 1 1 1 0 Cellulase (glycosyl hydrolase family 5) Pkinase PF00069.25 EDO16560.1 - 6.4e-43 147.0 4.7 5.2e-21 75.2 3.1 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EDO16560.1 - 9.4e-14 51.3 3.5 3.7e-09 36.3 1.4 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase YchF-GTPase_C PF06071.13 EDO16560.1 - 0.0041 17.3 0.6 0.0098 16.1 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF933) Pox_ser-thr_kin PF05445.11 EDO16560.1 - 0.041 12.9 0.4 0.08 11.9 0.2 1.5 1 1 0 1 1 1 0 Poxvirus serine/threonine protein kinase HEM4 PF02602.15 EDO16561.1 - 6e-46 156.7 0.0 6.8e-46 156.5 0.0 1.0 1 0 0 1 1 1 1 Uroporphyrinogen-III synthase HemD TRAPPC10 PF12584.8 EDO16562.1 - 1.5e-12 47.5 0.1 1.4e-11 44.3 0.0 2.1 2 0 0 2 2 2 1 Trafficking protein particle complex subunit 10, TRAPPC10 Gryzun-like PF12742.7 EDO16562.1 - 6.3e-05 22.9 0.1 0.00047 20.1 0.0 2.4 2 0 0 2 2 2 1 Gryzun, putative Golgi trafficking Foie-gras_1 PF11817.8 EDO16562.1 - 0.0073 15.9 0.0 0.014 15.0 0.0 1.3 1 0 0 1 1 1 1 Foie gras liver health family 1 DUF3119 PF11317.8 EDO16562.1 - 0.026 14.8 1.4 0.089 13.1 1.4 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3119) TPR_12 PF13424.6 EDO16562.1 - 0.13 12.6 0.0 0.25 11.7 0.0 1.4 1 0 0 1 1 1 0 Tetratricopeptide repeat PPC PF04151.15 EDO16562.1 - 0.34 12.1 2.0 1.6 9.9 0.4 2.9 2 0 0 2 2 2 0 Bacterial pre-peptidase C-terminal domain GHMP_kinases_N PF00288.26 EDO16564.1 - 2.1e-15 56.7 0.6 5.4e-15 55.4 0.6 1.7 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 EDO16564.1 - 0.00033 21.0 0.0 0.00077 19.8 0.0 1.6 1 0 0 1 1 1 1 GHMP kinases C terminal VP9 PF09625.10 EDO16564.1 - 0.015 15.4 0.1 3.5 7.9 0.0 2.6 2 0 0 2 2 2 0 VP9 protein FSH1 PF03959.13 EDO16565.1 - 3.5e-60 203.3 0.0 3.9e-60 203.1 0.0 1.0 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_2 PF02230.16 EDO16565.1 - 8.9e-05 22.4 0.0 0.0011 18.9 0.0 2.2 2 1 0 2 2 2 1 Phospholipase/Carboxylesterase UCH PF00443.29 EDO16566.1 - 1.3e-51 175.6 3.1 1.7e-51 175.2 3.1 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EDO16566.1 - 4.9e-18 65.8 5.5 1.7e-16 60.8 5.5 2.3 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 EDO16566.1 - 2.3e-12 47.1 10.7 2.3e-12 47.1 10.7 2.8 3 0 0 3 3 3 1 Zn-finger in ubiquitin-hydrolases and other protein Cytochrom_c3_2 PF14537.6 EDO16566.1 - 0.053 14.0 0.3 0.053 14.0 0.3 3.5 4 0 0 4 4 4 0 Cytochrome c3 Rhodanese PF00581.20 EDO16567.1 - 1.1e-12 48.4 0.0 1.4e-12 48.1 0.0 1.1 1 0 0 1 1 1 1 Rhodanese-like domain DUF1400 PF07176.11 EDO16567.1 - 0.11 12.8 0.0 0.16 12.2 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF1400) RRP36 PF06102.12 EDO16568.1 - 2.5e-40 138.2 24.3 2.5e-40 138.2 24.3 2.2 2 0 0 2 2 2 1 rRNA biogenesis protein RRP36 MRP_L53 PF10780.9 EDO16569.1 - 2.2e-19 69.3 0.1 3.1e-19 68.9 0.1 1.2 1 0 0 1 1 1 1 39S ribosomal protein L53/MRP-L53 DUF1441 PF07278.11 EDO16569.1 - 0.049 13.6 0.1 0.052 13.5 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1441) Thioredoxin PF00085.20 EDO16570.1 - 2.1e-21 75.9 0.2 5.4e-21 74.5 0.0 1.8 2 0 0 2 2 2 1 Thioredoxin Thioredoxin_2 PF13098.6 EDO16570.1 - 6.6e-05 23.3 1.0 0.00048 20.5 0.1 2.6 2 1 0 2 2 2 1 Thioredoxin-like domain OST3_OST6 PF04756.13 EDO16570.1 - 0.00011 21.7 0.1 0.00021 20.7 0.0 1.5 2 0 0 2 2 2 1 OST3 / OST6 family, transporter family Thioredoxin_7 PF13899.6 EDO16570.1 - 0.0058 16.8 0.0 0.014 15.5 0.0 1.7 1 0 0 1 1 1 1 Thioredoxin-like TraF PF13728.6 EDO16570.1 - 0.011 15.6 0.0 0.02 14.7 0.0 1.4 1 0 0 1 1 1 0 F plasmid transfer operon protein Thioredoxin_8 PF13905.6 EDO16570.1 - 0.022 15.1 0.3 2.4 8.6 0.0 3.0 2 1 1 3 3 3 0 Thioredoxin-like Glutaredoxin PF00462.24 EDO16570.1 - 0.027 14.7 0.1 0.093 13.0 0.1 2.0 1 0 0 1 1 1 0 Glutaredoxin PriC PF07445.12 EDO16571.1 - 0.02 14.9 5.7 0.049 13.5 5.7 1.6 1 0 0 1 1 1 0 Primosomal replication protein priC DUF3848 PF12959.7 EDO16571.1 - 0.066 13.3 3.0 0.52 10.4 0.8 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF3848) Thump_like PF18096.1 EDO16571.1 - 0.13 12.2 0.0 0.32 11.0 0.0 1.6 1 0 0 1 1 1 0 THUMP domain-like DALR_1 PF05746.15 EDO16571.1 - 0.14 12.4 1.0 0.3 11.3 0.3 1.9 2 0 0 2 2 2 0 DALR anticodon binding domain P4Ha_N PF08336.11 EDO16571.1 - 1.9 8.5 11.7 0.14 12.2 5.6 2.3 2 1 0 2 2 2 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region SET PF00856.28 EDO16572.1 - 0.0016 18.9 0.0 0.0026 18.1 0.0 1.5 1 0 0 1 1 1 1 SET domain BPL_LplA_LipB PF03099.19 EDO16573.1 - 6.4e-19 68.2 0.1 9.8e-19 67.6 0.1 1.3 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family FHA PF00498.26 EDO16574.1 - 1.3e-18 67.0 0.2 4.3e-17 62.2 0.1 2.7 2 0 0 2 2 2 1 FHA domain Yop-YscD_cpl PF16697.5 EDO16574.1 - 1.8e-05 25.0 0.3 6.1e-05 23.3 0.0 1.9 2 0 0 2 2 2 1 Inner membrane component of T3SS, cytoplasmic domain ARGLU PF15346.6 EDO16574.1 - 0.016 15.1 12.9 0.035 14.0 12.9 1.5 1 0 0 1 1 1 0 Arginine and glutamate-rich 1 Exonuc_VII_L PF02601.15 EDO16574.1 - 0.91 9.0 9.4 1.9 8.0 9.4 1.6 1 0 0 1 1 1 0 Exonuclease VII, large subunit Ax_dynein_light PF10211.9 EDO16574.1 - 1.6 8.6 15.2 2 8.3 13.9 1.7 2 0 0 2 2 2 0 Axonemal dynein light chain Mit_KHE1 PF10173.9 EDO16574.1 - 3 7.9 9.4 2.1 8.4 0.1 2.3 2 0 0 2 2 2 0 Mitochondrial K+-H+ exchange-related DUF4407 PF14362.6 EDO16574.1 - 3.9 6.8 6.4 6.2 6.1 6.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DASH_Spc19 PF08287.11 EDO16575.1 - 2.8e-34 118.3 12.5 3.5e-34 118.0 12.5 1.1 1 0 0 1 1 1 1 Spc19 SlyX PF04102.12 EDO16575.1 - 0.00054 20.5 6.1 0.2 12.3 0.0 3.3 3 0 0 3 3 3 2 SlyX FapA PF03961.13 EDO16575.1 - 0.0051 15.5 4.4 0.0063 15.2 4.4 1.2 1 0 0 1 1 1 1 Flagellar Assembly Protein A AAA_23 PF13476.6 EDO16575.1 - 0.01 16.3 5.8 0.013 16.0 5.8 1.1 1 0 0 1 1 1 0 AAA domain GIT_CC PF16559.5 EDO16575.1 - 0.018 14.9 15.8 0.4 10.6 0.2 3.7 3 1 0 3 3 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor Phage_GP20 PF06810.11 EDO16575.1 - 0.033 14.0 9.0 0.7 9.7 1.3 3.1 2 1 1 3 3 3 0 Phage minor structural protein GP20 FlaC_arch PF05377.11 EDO16575.1 - 0.035 14.5 8.8 0.63 10.5 0.2 3.5 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) HTH_Crp_2 PF13545.6 EDO16575.1 - 0.037 14.0 0.8 0.17 11.9 0.2 2.3 2 1 0 2 2 2 0 Crp-like helix-turn-helix domain APG6_N PF17675.1 EDO16575.1 - 0.34 11.4 15.2 0.35 11.4 11.3 2.3 1 1 1 2 2 2 0 Apg6 coiled-coil region DUF4140 PF13600.6 EDO16575.1 - 0.45 11.0 8.3 1.1 9.7 1.6 2.8 2 1 1 3 3 3 0 N-terminal domain of unknown function (DUF4140) DUF4763 PF15960.5 EDO16575.1 - 1.8 7.8 9.7 1.1 8.5 7.1 1.8 1 1 0 2 2 2 0 Domain of unknown function (DUF4763) ZapB PF06005.12 EDO16575.1 - 2 8.9 16.5 5.2e+03 -2.0 16.5 2.8 1 1 0 1 1 1 0 Cell division protein ZapB Prefoldin_2 PF01920.20 EDO16575.1 - 2.7 8.0 12.1 16 5.5 0.9 3.1 3 0 0 3 3 3 0 Prefoldin subunit Val_tRNA-synt_C PF10458.9 EDO16575.1 - 4.5 7.6 12.5 1.7 9.0 0.4 2.8 3 0 0 3 3 2 0 Valyl tRNA synthetase tRNA binding arm DASH_Dad2 PF08654.10 EDO16575.1 - 6.1 7.3 13.3 2.5 8.6 2.8 3.0 2 1 1 3 3 3 0 DASH complex subunit Dad2 Rogdi_lz PF10259.9 EDO16576.1 - 1.8e-61 208.0 3.1 2e-61 207.8 3.1 1.0 1 0 0 1 1 1 1 Rogdi leucine zipper containing protein HSP9_HSP12 PF04119.12 EDO16576.1 - 0.15 12.5 0.2 0.35 11.3 0.2 1.5 1 0 0 1 1 1 0 Heat shock protein 9/12 Coq4 PF05019.13 EDO16577.1 - 2.4e-96 321.3 0.0 3.2e-96 320.9 0.0 1.2 1 0 0 1 1 1 1 Coenzyme Q (ubiquinone) biosynthesis protein Coq4 Aminotran_3 PF00202.21 EDO16578.1 - 7.8e-102 340.9 0.0 8.9e-102 340.8 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III ATP-synt_F PF01990.17 EDO16579.1 - 3.9e-32 110.4 0.3 4.7e-32 110.2 0.3 1.1 1 0 0 1 1 1 1 ATP synthase (F/14-kDa) subunit DXP_synthase_N PF13292.6 EDO16579.1 - 0.022 14.0 0.1 0.023 13.9 0.1 1.1 1 0 0 1 1 1 0 1-deoxy-D-xylulose-5-phosphate synthase DUF2956 PF11169.8 EDO16580.1 - 0.028 14.6 1.7 0.028 14.6 1.7 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2956) DUF2681 PF10883.8 EDO16580.1 - 0.065 13.6 5.3 0.15 12.5 5.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2681) Cpn60_TCP1 PF00118.24 EDO16581.1 - 0.063 11.9 0.4 0.074 11.7 0.4 1.1 1 0 0 1 1 1 0 TCP-1/cpn60 chaperonin family PH PF00169.29 EDO16582.1 - 2.6e-05 24.7 0.1 0.00033 21.1 0.0 3.2 2 0 0 2 2 2 1 PH domain PUF PF00806.19 EDO16583.1 - 3e-28 95.9 1.6 5.6e-05 22.6 0.0 6.5 6 0 0 6 6 6 5 Pumilio-family RNA binding repeat RRM_1 PF00076.22 EDO16583.1 - 3.4e-05 23.6 0.0 8.8e-05 22.2 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) eIF-5_eIF-2B PF01873.17 EDO16584.1 - 9.1e-38 128.7 0.0 1.7e-37 127.8 0.0 1.5 1 0 0 1 1 1 1 Domain found in IF2B/IF5 W2 PF02020.18 EDO16584.1 - 9.9e-20 70.5 0.0 9.9e-20 70.5 0.0 2.9 4 0 0 4 4 4 1 eIF4-gamma/eIF5/eIF2-epsilon DUF2387 PF09526.10 EDO16584.1 - 0.13 12.4 0.6 0.32 11.2 0.1 1.9 2 0 0 2 2 2 0 Probable metal-binding protein (DUF2387) Zn-ribbon_8 PF09723.10 EDO16584.1 - 0.14 12.3 0.9 0.41 10.8 0.9 1.7 1 0 0 1 1 1 0 Zinc ribbon domain TPR_8 PF13181.6 EDO16585.1 - 8.3e-09 35.0 0.9 2.9e-07 30.2 0.0 3.1 3 0 0 3 3 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 EDO16585.1 - 4.6e-08 32.6 0.1 1.8e-07 30.8 0.1 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 EDO16585.1 - 2.3e-07 30.3 0.3 7.5e-07 28.7 0.0 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.6 EDO16585.1 - 0.0027 17.6 0.0 0.01 15.8 0.0 2.0 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_16 PF13432.6 EDO16585.1 - 0.0029 18.2 0.0 0.16 12.6 0.0 2.0 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.6 EDO16585.1 - 0.0063 17.0 0.0 0.022 15.3 0.0 1.9 2 0 0 2 2 2 1 Tetratricopeptide repeat DHNA PF04038.12 EDO16585.1 - 0.01 16.3 1.4 3.4 8.2 0.1 3.2 3 0 0 3 3 3 0 Dihydroneopterin aldolase TPR_17 PF13431.6 EDO16585.1 - 0.02 15.3 0.0 4.8 7.8 0.0 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.6 EDO16585.1 - 0.025 14.3 0.0 0.06 13.0 0.0 1.7 1 0 0 1 1 1 0 TPR repeat TPR_6 PF13174.6 EDO16585.1 - 0.04 14.6 0.0 0.21 12.3 0.0 2.2 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_12 PF13424.6 EDO16585.1 - 0.052 13.8 0.0 0.15 12.4 0.0 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat Gemini_AL3 PF01407.17 EDO16585.1 - 0.063 13.1 0.7 0.41 10.5 0.2 2.3 2 0 0 2 2 2 0 Geminivirus AL3 protein TPR_10 PF13374.6 EDO16585.1 - 0.15 12.0 0.0 0.67 9.9 0.0 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 EDO16585.1 - 0.16 12.8 0.0 0.44 11.5 0.0 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat TIP41 PF04176.13 EDO16586.1 - 4.9e-64 215.0 1.3 6.8e-64 214.5 1.3 1.2 1 0 0 1 1 1 1 TIP41-like family Evr1_Alr PF04777.13 EDO16587.1 - 3.9e-25 88.2 0.1 5.8e-25 87.7 0.1 1.3 1 0 0 1 1 1 1 Erv1 / Alr family APOBEC1 PF18769.1 EDO16587.1 - 0.017 15.3 0.0 0.03 14.6 0.0 1.4 1 0 0 1 1 1 0 APOBEC1 XOO_2897-deam PF14440.6 EDO16587.1 - 0.14 12.2 0.0 0.28 11.3 0.0 1.4 1 0 0 1 1 1 0 Xanthomonas XOO_2897-like deaminase Gln-synt_C PF00120.24 EDO16589.1 - 3.5e-22 78.9 0.0 4.4e-17 62.1 0.0 2.1 2 0 0 2 2 2 2 Glutamine synthetase, catalytic domain Gln-synt_N PF03951.19 EDO16589.1 - 2.7e-14 52.6 0.0 4.9e-14 51.8 0.0 1.4 1 0 0 1 1 1 1 Glutamine synthetase, beta-Grasp domain Actin PF00022.19 EDO16590.1 - 5.1e-45 153.8 0.7 5.6e-35 120.7 0.1 2.2 2 0 0 2 2 2 2 Actin MreB_Mbl PF06723.13 EDO16590.1 - 0.00026 19.9 0.0 0.061 12.1 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein NuA4 PF09340.10 EDO16591.1 - 4.5e-22 77.7 0.9 7e-22 77.1 0.9 1.3 1 0 0 1 1 1 1 Histone acetyltransferase subunit NuA4 YabA PF06156.13 EDO16591.1 - 0.0096 16.5 0.7 0.014 16.0 0.7 1.3 1 0 0 1 1 1 1 Initiation control protein YabA DUF4686 PF15742.5 EDO16591.1 - 0.01 15.0 4.7 0.013 14.6 4.7 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4686) DUF4298 PF14131.6 EDO16591.1 - 0.02 14.8 2.8 0.03 14.3 2.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4298) HlyD_2 PF12700.7 EDO16591.1 - 0.05 12.4 4.6 0.052 12.3 4.6 1.0 1 0 0 1 1 1 0 HlyD family secretion protein Mod_r PF07200.13 EDO16591.1 - 0.069 13.3 7.0 0.091 12.9 7.0 1.2 1 0 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein AIM24 PF01987.17 EDO16592.1 - 2e-39 135.5 0.0 3.4e-39 134.7 0.0 1.4 1 0 0 1 1 1 1 Mitochondrial biogenesis AIM24 tRNA-synt_His PF13393.6 EDO16593.1 - 6.2e-38 130.8 0.0 5.1e-37 127.8 0.0 2.0 1 1 0 1 1 1 1 Histidyl-tRNA synthetase HGTP_anticodon PF03129.20 EDO16593.1 - 9.9e-15 54.5 0.0 1.9e-14 53.6 0.0 1.5 1 0 0 1 1 1 1 Anticodon binding domain HGTP_anticodon2 PF12745.7 EDO16593.1 - 0.00022 20.8 0.2 0.0007 19.2 0.0 1.8 2 0 0 2 2 2 1 Anticodon binding domain of tRNAs tRNA-synt_2 PF00152.20 EDO16593.1 - 0.041 13.0 0.0 0.12 11.4 0.0 1.8 2 0 0 2 2 2 0 tRNA synthetases class II (D, K and N) OGG_N PF07934.12 EDO16593.1 - 0.14 12.2 0.0 0.4 10.8 0.0 1.9 1 1 0 1 1 1 0 8-oxoguanine DNA glycosylase, N-terminal domain Ribosomal_60s PF00428.19 EDO16593.1 - 1.1 9.9 8.1 4.5 7.9 1.2 3.4 3 0 0 3 3 3 0 60s Acidic ribosomal protein IDO PF01231.18 EDO16594.1 - 2.1e-133 445.3 0.0 1.1e-131 439.6 0.0 2.0 1 1 0 1 1 1 1 Indoleamine 2,3-dioxygenase zf-C2HCIx2C PF10782.9 EDO16594.1 - 0.14 12.1 0.0 0.31 11.0 0.0 1.5 1 0 0 1 1 1 0 Zinc-finger Cid2 PF09774.9 EDO16595.1 - 3.3e-41 141.4 2.2 4.3e-41 141.0 2.2 1.1 1 0 0 1 1 1 1 Caffeine-induced death protein 2 Pkinase PF00069.25 EDO16596.1 - 1.2e-59 201.8 0.0 3.1e-59 200.5 0.0 1.7 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO16596.1 - 5.8e-35 120.8 0.0 1.2e-34 119.8 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase HR1 PF02185.16 EDO16596.1 - 4.9e-20 71.4 25.6 1.2e-12 47.7 7.5 2.9 3 0 0 3 3 3 2 Hr1 repeat C1_1 PF00130.22 EDO16596.1 - 6.4e-18 64.4 35.1 6e-11 42.1 14.6 2.4 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) Pkinase_C PF00433.24 EDO16596.1 - 1.4e-12 48.1 3.6 5.9e-12 46.1 3.6 2.2 1 0 0 1 1 1 1 Protein kinase C terminal domain C2 PF00168.30 EDO16596.1 - 0.00063 20.0 0.1 0.0019 18.5 0.1 1.8 1 0 0 1 1 1 1 C2 domain Kinase-like PF14531.6 EDO16596.1 - 0.00085 18.7 4.3 0.0015 17.9 0.0 3.0 3 1 1 4 4 4 1 Kinase-like TPPII_N PF12583.8 EDO16596.1 - 0.15 12.7 0.3 1.3 9.6 0.1 2.4 2 0 0 2 2 2 0 Tripeptidyl peptidase II N terminal zf-RING_9 PF13901.6 EDO16596.1 - 0.47 10.4 32.8 0.25 11.3 6.6 3.8 3 0 0 3 3 3 0 Putative zinc-RING and/or ribbon Uds1 PF15456.6 EDO16596.1 - 1.6 8.9 13.7 0.19 11.9 1.3 3.0 3 0 0 3 3 3 0 Up-regulated During Septation zinc_ribbon_16 PF17034.5 EDO16597.1 - 1.6e-27 96.1 9.5 8.6e-27 93.8 9.5 2.2 1 1 0 1 1 1 1 Zinc-ribbon like family Zn_ribbon_17 PF17120.5 EDO16597.1 - 9.1e-06 25.2 7.5 9.1e-06 25.2 7.5 2.0 2 0 0 2 2 2 1 Zinc-ribbon, C4HC2 type zf-RING_2 PF13639.6 EDO16597.1 - 5.4 7.4 11.0 4.3 7.8 3.2 3.5 3 0 0 3 3 3 0 Ring finger domain zf-HC5HC2H_2 PF13832.6 EDO16598.1 - 5.1e-32 110.3 17.8 5.2e-31 107.1 11.7 2.8 2 0 0 2 2 2 2 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 EDO16598.1 - 4.2e-27 94.2 9.6 4.2e-27 94.2 9.6 3.6 2 1 1 3 3 3 1 PHD-like zinc-binding domain EPL1 PF10513.9 EDO16598.1 - 1e-13 51.9 3.1 1e-13 51.9 3.1 1.9 2 0 0 2 2 2 1 Enhancer of polycomb-like PHD_2 PF13831.6 EDO16598.1 - 3e-13 49.1 2.7 3e-13 49.1 2.7 2.9 2 0 0 2 2 2 1 PHD-finger PHD PF00628.29 EDO16598.1 - 1.2e-10 41.1 4.9 1.2e-10 41.1 4.9 2.9 3 0 0 3 3 3 2 PHD-finger C1_1 PF00130.22 EDO16598.1 - 0.0012 18.7 0.6 0.0012 18.7 0.6 2.9 3 0 0 3 3 3 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Prok-RING_1 PF14446.6 EDO16598.1 - 0.0012 18.7 22.7 0.0023 17.8 2.9 2.8 3 0 0 3 3 3 2 Prokaryotic RING finger family 1 zf-PHD-like PF15446.6 EDO16598.1 - 0.01 15.4 5.1 0.01 15.4 5.1 2.6 2 0 0 2 2 2 0 PHD/FYVE-zinc-finger like domain C1_2 PF03107.16 EDO16598.1 - 0.84 10.0 24.1 0.33 11.3 3.3 3.5 3 0 0 3 3 3 0 C1 domain zf-RING-like PF08746.11 EDO16598.1 - 7.9 6.9 26.0 0.19 12.0 8.7 3.7 3 1 0 3 3 3 0 RING-like domain Arrestin_C PF02752.22 EDO16599.1 - 2e-09 38.0 2.9 1.8e-06 28.5 0.0 4.1 2 2 0 2 2 2 2 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 EDO16599.1 - 0.061 13.4 0.0 1.8 8.6 0.0 2.6 2 0 0 2 2 2 0 Arrestin (or S-antigen), N-terminal domain Pro_isomerase PF00160.21 EDO16600.1 - 1.2e-47 162.2 0.0 1.4e-47 161.9 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Thioredoxin_3 PF13192.6 EDO16600.1 - 0.16 12.1 0.0 0.27 11.3 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin domain Sybindin PF04099.12 EDO16601.1 - 3.1e-19 69.3 0.5 3.6e-19 69.1 0.5 1.2 1 0 0 1 1 1 1 Sybindin-like family Sedlin_N PF04628.13 EDO16601.1 - 0.0018 18.4 0.3 0.0022 18.1 0.3 1.2 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region LptD PF04453.14 EDO16601.1 - 0.0025 17.1 0.4 0.0031 16.8 0.4 1.2 1 0 0 1 1 1 1 LPS transport system D HMG-CoA_red PF00368.18 EDO16602.1 - 9.7e-142 472.3 0.7 1.3e-141 471.9 0.7 1.2 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A reductase HPIH PF13323.6 EDO16602.1 - 2e-44 151.2 3.1 5e-44 149.9 3.1 1.7 1 0 0 1 1 1 1 N-terminal domain with HPIH motif Sterol-sensing PF12349.8 EDO16602.1 - 4e-06 26.8 5.7 4e-06 26.8 5.7 2.0 2 0 0 2 2 2 1 Sterol-sensing domain of SREBP cleavage-activation Col_cuticle_N PF01484.17 EDO16602.1 - 0.5 10.5 4.4 2.2 8.4 1.4 3.3 3 0 0 3 3 3 0 Nematode cuticle collagen N-terminal domain Piwi PF02171.17 EDO16603.1 - 4.5e-64 216.6 0.7 4.5e-64 216.6 0.7 2.3 3 0 0 3 3 3 1 Piwi domain AGO_N PF18236.1 EDO16603.1 - 6.4e-57 191.1 0.0 6.4e-57 191.1 0.0 3.7 2 1 1 3 3 3 1 Argonaute N domain Ago_N_1 PF18351.1 EDO16603.1 - 1.8e-46 156.5 0.4 1.8e-46 156.5 0.4 3.2 3 0 0 3 3 3 1 Fungal Argonaute N-terminal domain PAZ PF02170.22 EDO16603.1 - 0.00028 20.7 0.0 0.00094 19.0 0.0 1.9 1 0 0 1 1 1 1 PAZ domain Macoilin PF09726.9 EDO16603.1 - 0.23 10.0 28.7 0.39 9.2 28.7 1.3 1 0 0 1 1 1 0 Macoilin family SOG2 PF10428.9 EDO16603.1 - 3.8 6.6 28.0 7.3 5.7 28.0 1.4 1 0 0 1 1 1 0 RAM signalling pathway protein Ribosomal_L6e PF01159.19 EDO16604.1 - 4.8e-37 126.9 3.4 6.6e-37 126.4 3.4 1.2 1 0 0 1 1 1 1 Ribosomal protein L6e vATP-synt_AC39 PF01992.16 EDO16605.1 - 5.8e-106 354.8 2.7 6.6e-106 354.6 2.7 1.0 1 0 0 1 1 1 1 ATP synthase (C/AC39) subunit Cyt-b5 PF00173.28 EDO16606.1 - 1.4e-08 34.8 0.0 2e-08 34.2 0.0 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain BAR PF03114.18 EDO16607.1 - 1.8e-10 40.9 6.2 5e-10 39.4 6.2 1.7 1 1 0 1 1 1 1 BAR domain Atg14 PF10186.9 EDO16607.1 - 0.0032 16.6 3.3 0.0052 15.9 1.6 1.9 2 0 0 2 2 2 1 Vacuolar sorting 38 and autophagy-related subunit 14 Val_tRNA-synt_C PF10458.9 EDO16607.1 - 0.72 10.2 4.6 13 6.2 1.9 2.4 2 0 0 2 2 2 0 Valyl tRNA synthetase tRNA binding arm EF-hand_14 PF17959.1 EDO16607.1 - 2.6 8.4 6.0 9.4 6.7 1.0 2.7 3 0 0 3 3 3 0 EF-hand domain Dak1 PF02733.17 EDO16608.1 - 3.1e-107 358.1 0.3 4.4e-107 357.6 0.3 1.1 1 0 0 1 1 1 1 Dak1 domain Dak2 PF02734.17 EDO16608.1 - 2.5e-48 164.3 1.3 4.2e-48 163.5 0.7 1.7 2 0 0 2 2 2 1 DAK2 domain Rtt106 PF08512.12 EDO16609.1 - 2.1e-29 101.8 0.1 1.2e-25 89.7 0.0 3.3 3 0 0 3 3 3 1 Histone chaperone Rttp106-like SSrecog PF03531.14 EDO16609.1 - 5e-29 100.0 0.1 5e-29 100.0 0.1 4.1 5 0 0 5 5 5 1 Structure-specific recognition protein (SSRP1) POB3_N PF17292.2 EDO16609.1 - 2.5e-28 98.3 0.5 5.8e-25 87.5 0.1 2.9 3 0 0 3 3 3 2 POB3-like N-terminal PH domain TfuA PF07812.12 EDO16609.1 - 0.087 12.6 0.0 0.26 11.0 0.0 1.7 1 0 0 1 1 1 0 TfuA-like protein IBR PF01485.21 EDO16610.1 - 1.4e-12 47.7 29.6 2.5e-08 34.0 3.7 4.0 3 1 0 3 3 3 2 IBR domain, a half RING-finger domain zf-RING_2 PF13639.6 EDO16610.1 - 0.004 17.5 8.1 0.004 17.5 8.1 4.9 3 2 2 5 5 5 2 Ring finger domain SUR7 PF06687.12 EDO16611.1 - 0.06 13.0 13.5 0.49 10.0 13.5 2.3 1 1 0 1 1 1 0 SUR7/PalI family BAH PF01426.18 EDO16612.1 - 4e-13 49.3 1.3 1e-12 48.0 1.3 1.8 1 0 0 1 1 1 1 BAH domain AAA_lid_10 PF17872.1 EDO16612.1 - 4.3e-05 23.6 7.4 0.00013 22.1 0.1 3.6 3 0 0 3 3 3 1 AAA lid domain TniB PF05621.11 EDO16612.1 - 0.00076 18.9 0.0 0.0017 17.8 0.0 1.5 1 0 0 1 1 1 1 Bacterial TniB protein AAA_22 PF13401.6 EDO16612.1 - 0.0092 16.3 0.0 0.034 14.4 0.0 1.9 1 0 0 1 1 1 1 AAA domain OPA3 PF07047.12 EDO16612.1 - 0.021 14.6 0.0 0.097 12.4 0.0 2.2 2 0 0 2 2 2 0 Optic atrophy 3 protein (OPA3) AAA_16 PF13191.6 EDO16612.1 - 0.14 12.6 0.0 0.37 11.2 0.0 1.8 1 0 0 1 1 1 0 AAA ATPase domain Ras PF00071.22 EDO16613.1 - 5.2e-31 107.4 0.2 6.3e-31 107.2 0.2 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EDO16613.1 - 9.5e-22 77.5 0.1 2.4e-21 76.2 0.0 1.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 EDO16613.1 - 3.8e-06 26.4 0.6 4.8e-06 26.1 0.6 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Arf PF00025.21 EDO16613.1 - 2.5e-05 23.8 0.1 3.4e-05 23.4 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family DLIC PF05783.11 EDO16613.1 - 0.0016 17.3 0.0 0.26 10.1 0.0 2.1 2 0 0 2 2 2 2 Dynein light intermediate chain (DLIC) MMR_HSR1 PF01926.23 EDO16613.1 - 0.0065 16.5 0.1 0.012 15.7 0.1 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_7 PF12775.7 EDO16613.1 - 0.0099 15.4 1.6 0.021 14.4 0.1 1.9 2 0 0 2 2 2 1 P-loop containing dynein motor region Phage_endo_I PF05367.11 EDO16614.1 - 0.013 15.1 0.6 0.034 13.8 0.0 2.0 2 0 0 2 2 2 0 Phage endonuclease I IL2 PF00715.17 EDO16614.1 - 0.026 14.5 3.3 2.8 7.9 0.1 2.7 1 1 1 2 2 2 0 Interleukin 2 Sec39 PF08314.11 EDO16615.1 - 3.5e-119 399.4 19.3 1.6e-118 397.3 19.3 1.8 1 1 0 1 1 1 1 Secretory pathway protein Sec39 RAC_head PF16717.5 EDO16615.1 - 0.023 15.7 0.0 0.1 13.6 0.0 2.1 1 0 0 1 1 1 0 Ribosome-associated complex head domain PIF1 PF05970.14 EDO16616.1 - 3.1e-61 207.6 10.5 2.8e-60 204.4 1.7 3.0 2 1 0 2 2 2 1 PIF1-like helicase AAA_30 PF13604.6 EDO16616.1 - 2.9e-23 82.6 0.0 4.4e-23 82.0 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EDO16616.1 - 2.3e-11 44.2 0.0 4.7e-11 43.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain DUF2075 PF09848.9 EDO16616.1 - 8e-06 25.3 0.0 1.7e-05 24.3 0.0 1.5 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_22 PF13401.6 EDO16616.1 - 6.4e-05 23.3 0.3 0.00031 21.0 0.3 2.1 1 1 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 EDO16616.1 - 0.00025 20.5 0.1 0.0006 19.3 0.1 1.6 1 1 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA PF00004.29 EDO16616.1 - 0.0059 17.0 0.1 0.024 15.0 0.0 2.1 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) DEAD PF00270.29 EDO16616.1 - 0.0083 15.9 0.1 5.4 6.7 0.0 2.5 2 0 0 2 2 2 2 DEAD/DEAH box helicase FtsK_SpoIIIE PF01580.18 EDO16616.1 - 0.0089 15.4 0.1 0.03 13.7 0.0 1.8 2 0 0 2 2 2 1 FtsK/SpoIIIE family AAA_7 PF12775.7 EDO16616.1 - 0.015 14.9 0.0 0.032 13.7 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_24 PF13479.6 EDO16616.1 - 0.029 14.1 0.2 0.22 11.2 0.0 2.2 2 0 0 2 2 2 0 AAA domain T2SSE PF00437.20 EDO16616.1 - 0.036 13.1 0.0 0.068 12.2 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein PhoH PF02562.16 EDO16616.1 - 0.072 12.5 0.0 0.17 11.3 0.0 1.6 1 0 0 1 1 1 0 PhoH-like protein Helicase_RecD PF05127.14 EDO16616.1 - 0.088 12.7 0.3 1.3 8.9 0.3 2.5 1 1 0 1 1 1 0 Helicase AAA_29 PF13555.6 EDO16616.1 - 0.1 12.3 0.0 0.26 11.0 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_tran PF00005.27 EDO16616.1 - 0.11 13.0 0.8 0.74 10.3 0.1 2.4 2 0 0 2 2 2 0 ABC transporter UvrD_C_2 PF13538.6 EDO16616.1 - 0.17 11.7 0.2 0.79 9.6 0.2 2.1 1 1 0 1 1 1 0 UvrD-like helicase C-terminal domain Aminotran_3 PF00202.21 EDO16617.1 - 2.8e-121 405.0 0.0 3.2e-121 404.8 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Beta_elim_lyase PF01212.21 EDO16617.1 - 0.009 15.3 0.0 0.02 14.2 0.0 1.5 1 1 0 1 1 1 1 Beta-eliminating lyase OAM_dimer PF16554.5 EDO16617.1 - 0.12 12.8 0.0 0.29 11.6 0.0 1.6 2 0 0 2 2 2 0 Dimerisation domain of d-ornithine 4,5-aminomutase RNR_inhib PF08591.10 EDO16618.1 - 0.00046 21.4 0.3 0.00095 20.4 0.3 1.6 1 1 0 1 1 1 1 Ribonucleotide reductase inhibitor G_path_suppress PF15991.5 EDO16618.1 - 0.079 13.1 2.7 0.081 13.0 2.3 1.2 1 1 0 1 1 1 0 G-protein pathway suppressor RepA_C PF04796.12 EDO16619.1 - 2 8.4 5.2 0.66 10.0 1.5 2.1 2 0 0 2 2 2 0 Plasmid encoded RepA protein Myb_DNA-bind_5 PF13873.6 EDO16619.1 - 2.4 8.3 12.5 0.36 10.9 0.9 4.1 4 0 0 4 4 4 0 Myb/SANT-like DNA-binding domain SEN1_N PF12726.7 EDO16620.1 - 1.7e-212 707.8 17.3 2.7e-212 707.1 17.3 1.3 1 0 0 1 1 1 1 SEN1 N terminal AAA_11 PF13086.6 EDO16620.1 - 2.3e-72 243.9 0.2 2.3e-72 243.9 0.2 4.3 3 1 0 3 3 3 1 AAA domain AAA_12 PF13087.6 EDO16620.1 - 1.1e-59 201.4 0.0 1.1e-59 201.4 0.0 3.0 3 0 0 3 3 3 1 AAA domain AAA_30 PF13604.6 EDO16620.1 - 7e-09 35.7 0.0 0.00026 20.8 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.6 EDO16620.1 - 2.1e-08 34.6 0.0 1.4e-07 32.0 0.0 2.4 1 1 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 EDO16620.1 - 6e-06 26.2 0.0 0.051 13.3 0.0 3.7 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase ResIII PF04851.15 EDO16620.1 - 1.1 9.2 0.0 1.1 9.2 0.0 4.4 5 0 0 5 5 5 0 Type III restriction enzyme, res subunit Histone_H2A_C PF16211.5 EDO16622.1 - 3.8e-21 74.5 1.1 6.1e-21 73.9 1.1 1.4 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.24 EDO16622.1 - 8.8e-17 61.7 0.0 1.2e-16 61.3 0.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EDO16622.1 - 7.8e-06 26.1 0.0 1.2e-05 25.5 0.0 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone LcrG PF07216.12 EDO16622.1 - 0.041 13.8 0.0 0.065 13.2 0.0 1.4 1 0 0 1 1 1 0 LcrG protein Histone PF00125.24 EDO16623.1 - 1.3e-19 70.9 1.2 1.6e-19 70.5 1.2 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EDO16623.1 - 1.1e-06 28.9 0.1 2.1e-06 27.9 0.1 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.13 EDO16623.1 - 0.0013 19.2 0.0 0.0022 18.5 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A YscO-like PF16789.5 EDO16623.1 - 0.05 13.6 0.2 0.056 13.5 0.2 1.1 1 0 0 1 1 1 0 YscO-like protein CENP-W PF15510.6 EDO16623.1 - 0.083 13.1 0.0 0.12 12.6 0.0 1.2 1 0 0 1 1 1 0 CENP-W protein VIT1 PF01988.19 EDO16624.1 - 6.2e-60 202.7 0.0 7.5e-60 202.5 0.0 1.1 1 0 0 1 1 1 1 VIT family T3RM_EcoP15I_C PF18273.1 EDO16624.1 - 0.031 14.6 0.2 0.11 12.8 0.0 2.0 2 0 0 2 2 2 0 Type III R-M EcoP15I C-terminal domain CsgG PF03783.14 EDO16624.1 - 0.22 10.8 0.2 0.37 10.0 0.2 1.3 1 0 0 1 1 1 0 Curli production assembly/transport component CsgG Rsa3 PF14615.6 EDO16625.1 - 7e-20 70.3 0.6 1.2e-19 69.6 0.6 1.4 1 0 0 1 1 1 1 Ribosome-assembly protein 3 Peptidase_S8_N PF16361.5 EDO16625.1 - 0.043 14.3 1.7 0.1 13.1 1.7 1.7 1 1 0 1 1 1 0 N-terminal of Subtilase family DTHCT PF08070.11 EDO16625.1 - 0.22 12.3 9.3 0.34 11.7 9.3 1.5 1 1 0 1 1 1 0 DTHCT (NUC029) region XRN_M PF17846.1 EDO16625.1 - 0.61 9.0 6.3 0.7 8.8 6.3 1.0 1 0 0 1 1 1 0 Xrn1 helical domain Ferlin_C PF16165.5 EDO16625.1 - 0.77 9.7 4.0 1.1 9.2 4.0 1.3 1 0 0 1 1 1 0 Ferlin C-terminus CRF1 PF10380.9 EDO16626.1 - 1.6e-33 115.4 3.8 1.6e-33 115.4 3.8 5.8 5 2 0 6 6 6 1 Transcription factor CRF1 PRKCSH-like PF12999.7 EDO16627.1 - 1.7e-41 142.0 3.7 1.7e-41 142.0 3.7 2.5 3 1 0 3 3 3 1 Glucosidase II beta subunit-like PRKCSH_1 PF13015.6 EDO16627.1 - 7e-19 68.0 4.4 7e-18 64.8 4.4 2.6 1 1 0 1 1 1 1 Glucosidase II beta subunit-like protein NUDE_C PF04880.13 EDO16627.1 - 0.007 16.9 0.6 0.012 16.1 0.6 1.4 1 0 0 1 1 1 1 NUDE protein, C-terminal conserved region SlyX PF04102.12 EDO16627.1 - 0.26 11.9 4.1 6.7 7.4 0.6 2.9 2 0 0 2 2 2 0 SlyX ADIP PF11559.8 EDO16627.1 - 0.86 9.7 10.9 0.16 12.1 0.7 2.7 3 0 0 3 3 3 0 Afadin- and alpha -actinin-Binding Fez1 PF06818.15 EDO16627.1 - 1 9.8 11.9 3.1 8.2 2.5 2.3 2 0 0 2 2 2 0 Fez1 TPR_MLP1_2 PF07926.12 EDO16627.1 - 1.6 8.8 10.8 3.7 7.6 2.9 2.6 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein DivIC PF04977.15 EDO16627.1 - 2.1 8.2 8.6 3.4 7.5 0.7 2.7 2 0 0 2 2 2 0 Septum formation initiator Fib_alpha PF08702.10 EDO16627.1 - 2.1 8.5 19.3 1.6 8.9 1.1 4.2 3 1 1 4 4 4 0 Fibrinogen alpha/beta chain family LRR_4 PF12799.7 EDO16627.1 - 2.2 8.8 8.8 11 6.6 0.3 3.8 4 0 0 4 4 4 0 Leucine Rich repeats (2 copies) PRKG1_interact PF15898.5 EDO16627.1 - 2.5 9.0 8.3 9.8 7.1 1.8 3.0 2 0 0 2 2 2 0 cGMP-dependent protein kinase interacting domain F-box-like PF12937.7 EDO16628.1 - 2.2e-07 30.7 0.2 4e-07 29.8 0.2 1.4 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EDO16628.1 - 2.1e-05 24.3 0.5 5.2e-05 23.0 0.5 1.7 1 0 0 1 1 1 1 F-box domain F-box_4 PF15966.5 EDO16628.1 - 0.0018 18.2 0.1 0.005 16.7 0.1 1.7 1 0 0 1 1 1 1 F-box Septin PF00735.18 EDO16630.1 - 1.2e-67 228.2 0.2 2.2e-67 227.3 0.2 1.4 1 0 0 1 1 1 1 Septin Dynamin_N PF00350.23 EDO16630.1 - 0.0002 21.5 0.8 0.0016 18.5 0.0 2.4 2 0 0 2 2 2 1 Dynamin family RsgA_GTPase PF03193.16 EDO16630.1 - 0.00029 20.8 0.2 0.038 13.9 0.0 2.5 2 0 0 2 2 2 1 RsgA GTPase G-alpha PF00503.20 EDO16630.1 - 0.0026 17.0 0.4 0.017 14.3 0.2 1.9 1 1 0 2 2 2 1 G-protein alpha subunit ABC_tran PF00005.27 EDO16630.1 - 0.022 15.3 0.2 0.066 13.7 0.0 1.9 2 0 0 2 2 2 0 ABC transporter MMR_HSR1 PF01926.23 EDO16630.1 - 0.023 14.8 0.1 0.056 13.5 0.1 1.8 1 1 0 1 1 1 0 50S ribosome-binding GTPase AIG1 PF04548.16 EDO16630.1 - 0.044 13.1 0.0 0.095 12.0 0.0 1.5 1 0 0 1 1 1 0 AIG1 family AAA_33 PF13671.6 EDO16630.1 - 0.058 13.6 0.1 0.11 12.6 0.1 1.5 1 1 0 1 1 1 0 AAA domain FtsK_SpoIIIE PF01580.18 EDO16630.1 - 0.062 12.6 0.1 0.16 11.3 0.1 1.6 1 0 0 1 1 1 0 FtsK/SpoIIIE family Mg_chelatase PF01078.21 EDO16630.1 - 0.066 12.6 0.0 0.14 11.5 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI TRAF_BIRC3_bd PF16673.5 EDO16630.1 - 0.12 12.2 0.7 0.34 10.7 0.7 1.7 1 0 0 1 1 1 0 TNF receptor-associated factor BIRC3 binding domain AAA_16 PF13191.6 EDO16630.1 - 0.12 12.8 0.0 0.2 12.0 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain IL13 PF03487.13 EDO16631.1 - 0.026 14.3 0.1 0.11 12.3 0.1 2.1 1 0 0 1 1 1 0 Interleukin-13 Rad9_Rad53_bind PF08605.10 EDO16632.1 - 9.5e-40 135.8 0.1 1.9e-39 134.8 0.1 1.6 1 0 0 1 1 1 1 Fungal Rad9-like Rad53-binding BRCT PF00533.26 EDO16632.1 - 2.7e-09 37.3 1.6 9e-08 32.4 0.2 3.5 2 1 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 EDO16632.1 - 4e-05 23.9 0.4 0.00024 21.5 0.4 2.4 1 1 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain RTT107_BRCT_5 PF16770.5 EDO16632.1 - 0.00068 19.5 0.1 0.0025 17.7 0.1 2.0 1 0 0 1 1 1 1 Regulator of Ty1 transposition protein 107 BRCT domain zf-C2H2 PF00096.26 EDO16633.1 - 1.8e-08 34.3 13.0 4.9e-05 23.5 1.7 3.3 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EDO16633.1 - 4.2e-06 26.9 9.2 3.7e-05 24.0 5.9 2.6 2 0 0 2 2 2 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 EDO16633.1 - 3.6e-05 24.2 12.0 0.012 16.4 1.5 3.1 2 0 0 2 2 2 2 C2H2-type zinc finger zf-met PF12874.7 EDO16633.1 - 0.025 15.0 4.3 3.6 8.1 0.4 2.9 2 0 0 2 2 2 0 Zinc-finger of C2H2 type Aha1_N PF09229.11 EDO16634.1 - 3.1e-36 124.6 0.6 3.1e-36 124.6 0.6 2.1 3 0 0 3 3 3 1 Activator of Hsp90 ATPase, N-terminal AHSA1 PF08327.11 EDO16634.1 - 4.2e-12 46.4 0.1 9.3e-12 45.3 0.1 1.6 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein Fungal_trans_2 PF11951.8 EDO16635.1 - 1.4e-11 43.9 1.4 3.6e-11 42.5 1.4 1.7 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDO16635.1 - 8.4e-08 32.2 12.7 1.3e-07 31.6 12.7 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Ras PF00071.22 EDO16636.1 - 9.9e-51 171.6 0.0 1.1e-50 171.3 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EDO16636.1 - 1.7e-18 67.0 0.0 2.4e-18 66.5 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EDO16636.1 - 3.9e-07 29.7 0.0 5.2e-07 29.3 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Thymidylate_kin PF02223.17 EDO16637.1 - 1.9e-38 132.0 0.0 2.3e-38 131.7 0.0 1.1 1 0 0 1 1 1 1 Thymidylate kinase AAA_18 PF13238.6 EDO16637.1 - 0.0062 17.1 0.1 0.01 16.4 0.0 1.5 1 1 0 1 1 1 1 AAA domain CPT PF07931.12 EDO16637.1 - 0.0083 16.0 0.0 0.011 15.5 0.0 1.3 1 0 0 1 1 1 1 Chloramphenicol phosphotransferase-like protein AAA_33 PF13671.6 EDO16637.1 - 0.015 15.4 0.0 0.025 14.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain Pkinase PF00069.25 EDO16638.1 - 8.7e-37 126.9 0.0 1.6e-36 126.0 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO16638.1 - 2.8e-15 56.3 0.0 4.6e-15 55.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDO16638.1 - 0.0018 17.6 0.0 0.0069 15.7 0.0 1.9 2 0 0 2 2 2 1 Kinase-like DpaA_N PF16924.5 EDO16638.1 - 0.14 12.3 0.0 0.33 11.1 0.0 1.6 1 0 0 1 1 1 0 Dipicolinate synthase subunit A N-terminal domain NAD_binding_1 PF00175.21 EDO16639.1 - 4.5e-25 88.4 0.0 6.3e-25 87.9 0.0 1.2 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 EDO16639.1 - 5.6e-21 74.7 0.0 9.8e-21 74.0 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 EDO16639.1 - 1.9e-10 41.1 0.0 1.9e-07 31.3 0.0 2.5 1 1 1 2 2 2 2 Ferric reductase NAD binding domain SID PF11778.8 EDO16640.1 - 8.3e-55 184.6 6.8 8.3e-55 184.6 6.8 4.2 3 1 1 4 4 4 1 Septation initiation SlyX PF04102.12 EDO16640.1 - 0.00036 21.1 56.5 0.054 14.1 0.6 11.0 6 3 6 12 12 12 4 SlyX ZapB PF06005.12 EDO16640.1 - 0.0061 17.0 3.8 0.0061 17.0 3.8 10.5 5 3 4 10 10 10 2 Cell division protein ZapB Fez1 PF06818.15 EDO16640.1 - 0.012 16.1 1.5 0.012 16.1 1.5 7.4 1 1 6 7 7 7 0 Fez1 PKcGMP_CC PF16808.5 EDO16640.1 - 0.019 14.8 45.5 2.2 8.2 2.7 10.4 6 2 4 10 10 10 0 Coiled-coil N-terminus of cGMP-dependent protein kinase HrpB7 PF09486.10 EDO16640.1 - 1.2 9.5 20.2 0.36 11.2 0.8 6.0 4 3 3 7 7 7 0 Bacterial type III secretion protein (HrpB7) DUF641 PF04859.12 EDO16640.1 - 1.6 9.1 71.5 0.58 10.5 1.9 9.3 3 3 6 9 9 9 0 Plant protein of unknown function (DUF641) DnaJ PF00226.31 EDO16641.1 - 4.1e-23 81.3 0.3 1.3e-22 79.6 0.3 2.0 1 0 0 1 1 1 1 DnaJ domain zf-C2H2_jaz PF12171.8 EDO16641.1 - 1.9e-10 40.8 11.4 1.9e-09 37.5 3.0 3.6 3 0 0 3 3 3 1 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 EDO16641.1 - 2.6e-07 30.9 3.0 0.0068 17.2 0.5 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.26 EDO16641.1 - 1.2e-06 28.7 5.5 0.0043 17.4 1.0 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_2 PF12756.7 EDO16641.1 - 2.2e-06 27.9 7.2 0.0049 17.2 1.9 3.1 3 0 0 3 3 3 2 C2H2 type zinc-finger (2 copies) zf-met PF12874.7 EDO16641.1 - 3.3e-06 27.3 2.5 3.3e-06 27.3 2.5 2.8 3 0 0 3 3 3 1 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 EDO16641.1 - 0.0013 18.7 7.6 0.17 12.0 1.3 2.6 2 0 0 2 2 2 2 C2H2-type zinc finger zf-LYAR PF08790.11 EDO16641.1 - 0.0069 16.3 0.6 0.019 14.8 0.6 1.8 1 0 0 1 1 1 1 LYAR-type C2HC zinc finger zf-H2C2_2 PF13465.6 EDO16641.1 - 0.86 10.2 2.7 0.83 10.2 0.2 2.3 2 0 0 2 2 2 0 Zinc-finger double domain zf-C2H2_3rep PF18868.1 EDO16641.1 - 1.1 9.9 8.4 1.9 9.2 0.2 3.3 3 2 1 4 4 4 0 Zinc finger C2H2-type, 3 repeats GST_C PF00043.25 EDO16642.1 - 1.6e-23 82.7 0.0 1.6e-23 82.7 0.0 2.4 2 1 0 2 2 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EDO16642.1 - 4.5e-19 68.6 0.0 1.2e-18 67.2 0.0 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 EDO16642.1 - 7.4e-09 35.9 0.0 2.3e-08 34.3 0.0 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EDO16642.1 - 4.2e-08 33.4 0.0 1e-07 32.2 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EDO16642.1 - 2.3e-05 24.5 1.2 7.1e-05 22.9 0.0 2.3 2 1 0 2 2 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EDO16642.1 - 0.0014 18.6 0.0 0.0027 17.7 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain DDHD PF02862.17 EDO16642.1 - 0.0027 17.9 9.5 0.0043 17.2 9.5 1.4 1 0 0 1 1 1 1 DDHD domain PepSY_TM PF03929.16 EDO16642.1 - 0.028 14.1 1.1 0.036 13.7 1.1 1.3 1 0 0 1 1 1 0 PepSY-associated TM region DUF4746 PF15928.5 EDO16642.1 - 0.04 13.3 12.9 0.072 12.5 12.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) TFIIA PF03153.13 EDO16642.1 - 0.07 13.1 50.9 0.091 12.8 50.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF3408 PF11888.8 EDO16642.1 - 0.16 12.1 17.0 0.39 10.9 17.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) Suf PF05843.14 EDO16642.1 - 0.33 10.9 25.2 0.5 10.3 25.2 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Lin-8 PF03353.15 EDO16642.1 - 0.37 10.3 23.1 0.53 9.8 23.1 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist GREB1 PF15782.5 EDO16642.1 - 0.56 7.3 21.6 0.59 7.2 21.6 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Membralin PF09746.9 EDO16642.1 - 0.8 8.7 12.9 1.4 7.9 12.9 1.4 1 0 0 1 1 1 0 Tumour-associated protein Tho2 PF11262.8 EDO16642.1 - 1.1 8.4 15.2 1.6 7.8 15.2 1.2 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 DUF4407 PF14362.6 EDO16642.1 - 1.1 8.5 14.9 1.6 8.0 14.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Ureide_permease PF07168.11 EDO16642.1 - 1.5 7.5 5.7 2.1 7.0 5.7 1.3 1 0 0 1 1 1 0 Ureide permease RR_TM4-6 PF06459.12 EDO16642.1 - 1.6 8.5 17.5 2.2 8.0 17.5 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Presenilin PF01080.17 EDO16642.1 - 1.9 7.1 21.2 2.7 6.7 21.2 1.2 1 0 0 1 1 1 0 Presenilin FAM176 PF14851.6 EDO16642.1 - 2.3 7.9 9.7 3 7.5 8.8 1.6 2 0 0 2 2 1 0 FAM176 family PA26 PF04636.13 EDO16642.1 - 2.4 7.0 17.1 3.5 6.4 17.1 1.2 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Peptidase_S49_N PF08496.10 EDO16642.1 - 2.5 8.2 14.1 5.9 6.9 14.1 1.6 1 0 0 1 1 1 0 Peptidase family S49 N-terminal CLN3 PF02487.17 EDO16642.1 - 3.4 6.6 10.7 4.9 6.1 10.7 1.3 1 0 0 1 1 1 0 CLN3 protein CCSAP PF15748.5 EDO16642.1 - 3.7 7.7 21.9 5.5 7.1 21.9 1.2 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Zip PF02535.22 EDO16642.1 - 3.8 6.6 8.1 5 6.2 8.1 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter SprA-related PF12118.8 EDO16642.1 - 4.1 6.4 34.5 6.1 5.9 34.5 1.2 1 0 0 1 1 1 0 SprA-related family Med15 PF09606.10 EDO16642.1 - 4.5 5.8 43.5 8 5.0 43.5 1.3 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Connexin PF00029.19 EDO16642.1 - 4.5 6.9 10.6 7.2 6.3 10.6 1.3 1 0 0 1 1 1 0 Connexin PAT1 PF09770.9 EDO16642.1 - 5.9 5.0 35.0 7.5 4.7 35.0 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 CobT PF06213.12 EDO16642.1 - 7.2 5.9 27.2 18 4.6 23.1 2.1 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT YjbH PF06082.11 EDO16642.1 - 9.4 4.9 19.1 13 4.4 19.1 1.1 1 0 0 1 1 1 0 Exopolysaccharide biosynthesis protein YbjH Elongin_A PF06881.11 EDO16643.1 - 2.7e-15 56.8 5.2 2.7e-15 56.8 5.2 3.3 3 1 0 3 3 3 1 RNA polymerase II transcription factor SIII (Elongin) subunit A Globin PF00042.22 EDO16644.1 - 2.7e-05 24.7 0.0 7.6e-05 23.2 0.0 1.9 1 0 0 1 1 1 1 Globin Mem_trans PF03547.18 EDO16644.1 - 0.03 12.7 0.4 0.056 11.8 0.4 1.4 1 0 0 1 1 1 0 Membrane transport protein RhoGAP PF00620.27 EDO16645.1 - 3e-38 131.0 2.5 7.4e-38 129.8 0.4 2.7 2 0 0 2 2 2 1 RhoGAP domain LIM PF00412.22 EDO16645.1 - 1.3e-27 95.8 47.0 1.6e-12 47.4 5.4 4.5 4 0 0 4 4 4 4 LIM domain Fcf1 PF04900.12 EDO16645.1 - 0.019 15.3 0.1 0.13 12.6 0.1 2.5 1 0 0 1 1 1 0 Fcf1 ATG2_CAD PF13329.6 EDO16646.1 - 9.5e-32 109.9 0.9 9.5e-32 109.9 0.9 4.1 4 0 0 4 4 4 1 Autophagy-related protein 2 CAD motif ATG_C PF09333.11 EDO16646.1 - 9.9e-30 102.8 0.1 2.4e-29 101.5 0.1 1.7 1 0 0 1 1 1 1 Autophagy-related protein C terminal domain Epimerase PF01370.21 EDO16647.1 - 1.3e-18 67.4 0.0 1.7e-18 67.0 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EDO16647.1 - 6.4e-13 48.3 0.1 9e-13 47.9 0.1 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 EDO16647.1 - 3.5e-10 39.5 0.1 7.3e-09 35.2 0.1 2.0 1 1 0 1 1 1 1 Male sterility protein GDP_Man_Dehyd PF16363.5 EDO16647.1 - 5.2e-07 29.4 0.0 1.8e-06 27.6 0.0 1.7 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 EDO16647.1 - 1.5e-06 28.3 0.0 2.3e-06 27.6 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding KR PF08659.10 EDO16647.1 - 1.2e-05 25.3 0.0 2.8e-05 24.1 0.0 1.6 2 0 0 2 2 2 1 KR domain NmrA PF05368.13 EDO16647.1 - 4.1e-05 23.3 0.0 0.00054 19.6 0.0 2.2 2 0 0 2 2 2 1 NmrA-like family adh_short PF00106.25 EDO16647.1 - 8.1e-05 22.2 0.3 0.0011 18.5 0.0 2.3 1 1 0 2 2 2 1 short chain dehydrogenase Polysacc_synt_2 PF02719.15 EDO16647.1 - 9.1e-05 21.7 0.1 0.00017 20.9 0.1 1.4 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Shikimate_DH PF01488.20 EDO16647.1 - 0.011 15.8 0.0 0.022 14.8 0.0 1.6 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase adh_short_C2 PF13561.6 EDO16647.1 - 0.027 14.0 0.0 0.23 11.0 0.0 2.0 1 1 1 2 2 2 0 Enoyl-(Acyl carrier protein) reductase F420_oxidored PF03807.17 EDO16647.1 - 0.039 14.5 0.0 0.093 13.3 0.0 1.6 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Semialdhyde_dh PF01118.24 EDO16647.1 - 0.044 14.2 0.0 0.095 13.1 0.0 1.6 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain Glu_dehyd_C PF16912.5 EDO16647.1 - 0.1 12.1 0.1 6.8 6.1 0.0 2.2 1 1 1 2 2 2 0 Glucose dehydrogenase C-terminus PTR2 PF00854.21 EDO16648.1 - 4.9e-102 341.7 15.2 1.1e-101 340.6 13.5 2.1 1 1 0 1 1 1 1 POT family ADH_N PF08240.12 EDO16650.1 - 3.9e-25 87.9 6.7 6.8e-25 87.1 6.7 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EDO16650.1 - 7.7e-17 61.5 0.0 1.4e-16 60.6 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 EDO16650.1 - 7.6e-07 28.7 0.4 1.7e-06 27.5 0.3 1.5 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.21 EDO16650.1 - 0.0001 21.7 0.0 0.00022 20.6 0.0 1.5 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain DUF364 PF04016.12 EDO16650.1 - 0.00075 19.1 0.0 0.0014 18.2 0.0 1.3 1 0 0 1 1 1 1 Putative heavy-metal chelation NAD_binding_2 PF03446.15 EDO16650.1 - 0.014 15.6 0.1 0.021 15.0 0.1 1.3 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase Fer4_10 PF13237.6 EDO16650.1 - 0.063 13.4 3.1 1.8 8.7 0.3 2.4 2 0 0 2 2 2 0 4Fe-4S dicluster domain ApbA PF02558.16 EDO16650.1 - 0.066 12.9 0.0 0.1 12.2 0.0 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Hexapep_2 PF14602.6 EDO16650.1 - 0.081 12.7 2.9 0.072 12.9 1.2 1.9 2 0 0 2 2 2 0 Hexapeptide repeat of succinyl-transferase Epimerase PF01370.21 EDO16650.1 - 0.19 11.2 0.0 0.27 10.7 0.0 1.2 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family RseC_MucC PF04246.12 EDO16650.1 - 1.8 8.5 4.5 4.2 7.3 4.5 1.6 1 0 0 1 1 1 0 Positive regulator of sigma(E), RseC/MucC Flocculin PF00624.18 EDO16651.1 - 5.9e-130 423.3 751.4 1.6e-11 44.3 11.4 114.6 40 2 74 114 114 114 32 Flocculin repeat CBF PF03914.17 EDO16654.1 - 1.5e-48 165.1 0.4 1.5e-48 165.1 0.4 3.5 3 1 0 3 3 3 1 CBF/Mak21 family FliO PF04347.13 EDO16654.1 - 0.055 13.8 0.1 0.4 11.0 0.1 2.5 2 0 0 2 2 2 0 Flagellar biosynthesis protein, FliO UQ_con PF00179.26 EDO16655.1 - 2.6e-52 176.2 0.0 2.9e-52 176.0 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 EDO16655.1 - 0.0011 19.2 0.0 0.0016 18.7 0.0 1.2 1 0 0 1 1 1 1 RWD domain Prok-E2_B PF14461.6 EDO16655.1 - 0.0032 17.2 0.0 0.004 16.8 0.0 1.1 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.13 EDO16655.1 - 0.019 14.8 0.0 0.03 14.2 0.0 1.3 1 0 0 1 1 1 0 UEV domain Bromodomain PF00439.25 EDO16656.1 - 7.8e-15 54.7 0.5 2.9e-14 52.9 0.5 2.1 1 0 0 1 1 1 1 Bromodomain Bromo_TP PF07524.13 EDO16656.1 - 7.7e-07 29.0 0.0 2.8e-05 24.0 0.0 2.5 2 0 0 2 2 2 1 Bromodomain associated Yos9_DD PF17880.1 EDO16657.1 - 9.4e-49 164.8 1.0 3.2e-48 163.0 0.6 2.2 2 0 0 2 2 2 1 Yos9 dimerzation domain PRKCSH PF07915.13 EDO16657.1 - 2.5e-11 44.4 0.8 2.5e-11 44.4 0.8 3.1 3 0 0 3 3 3 1 Glucosidase II beta subunit-like protein AAA PF00004.29 EDO16659.1 - 2.9e-52 176.6 0.0 2.4e-38 131.6 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EDO16659.1 - 3.9e-10 39.4 0.0 8.7e-10 38.3 0.0 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_22 PF13401.6 EDO16659.1 - 1.5e-09 38.3 0.1 0.00095 19.5 0.0 3.1 2 2 1 3 3 3 2 AAA domain AAA_16 PF13191.6 EDO16659.1 - 4e-09 37.1 0.0 0.0015 19.0 0.0 2.6 2 1 0 2 2 2 2 AAA ATPase domain TIP49 PF06068.13 EDO16659.1 - 1.1e-07 31.5 0.1 0.0072 15.6 0.0 2.4 2 1 0 2 2 2 2 TIP49 P-loop domain CDC48_2 PF02933.17 EDO16659.1 - 2e-07 30.7 1.1 6.9e-07 29.0 0.2 2.2 2 0 0 2 2 2 1 Cell division protein 48 (CDC48), domain 2 Mg_chelatase PF01078.21 EDO16659.1 - 8.1e-07 28.6 0.0 0.0019 17.6 0.0 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_33 PF13671.6 EDO16659.1 - 1.5e-06 28.4 0.0 0.024 14.8 0.0 2.8 3 0 0 3 3 2 2 AAA domain AAA_5 PF07728.14 EDO16659.1 - 3.9e-06 26.9 0.0 0.0026 17.7 0.0 2.8 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) PhoH PF02562.16 EDO16659.1 - 5e-06 26.1 0.0 0.0056 16.2 0.0 2.4 2 0 0 2 2 2 2 PhoH-like protein RuvB_N PF05496.12 EDO16659.1 - 6.5e-06 26.0 0.4 0.068 12.9 0.1 3.1 3 0 0 3 3 3 2 Holliday junction DNA helicase RuvB P-loop domain CDC48_N PF02359.18 EDO16659.1 - 9e-06 25.8 0.0 4.2e-05 23.7 0.0 2.2 2 0 0 2 2 1 1 Cell division protein 48 (CDC48), N-terminal domain AAA_24 PF13479.6 EDO16659.1 - 1.4e-05 24.9 0.1 0.091 12.5 0.0 3.0 2 1 0 2 2 2 2 AAA domain ABC_tran PF00005.27 EDO16659.1 - 1.6e-05 25.4 0.2 0.034 14.6 0.1 2.7 2 0 0 2 2 2 1 ABC transporter AAA_2 PF07724.14 EDO16659.1 - 1.9e-05 24.9 0.0 0.0018 18.4 0.0 2.6 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) IstB_IS21 PF01695.17 EDO16659.1 - 2e-05 24.4 0.0 0.25 11.1 0.0 2.5 2 0 0 2 2 2 2 IstB-like ATP binding protein NB-ARC PF00931.22 EDO16659.1 - 2.2e-05 23.8 0.0 0.018 14.2 0.0 2.5 2 0 0 2 2 2 2 NB-ARC domain NACHT PF05729.12 EDO16659.1 - 2.9e-05 24.0 2.8 0.032 14.1 0.0 3.6 4 1 0 4 4 3 1 NACHT domain RNA_helicase PF00910.22 EDO16659.1 - 4e-05 24.0 0.0 0.13 12.7 0.0 2.9 3 0 0 3 3 2 2 RNA helicase Sigma54_activat PF00158.26 EDO16659.1 - 8.4e-05 22.3 0.0 0.22 11.2 0.0 2.4 2 0 0 2 2 2 2 Sigma-54 interaction domain TsaE PF02367.17 EDO16659.1 - 8.6e-05 22.5 0.0 0.52 10.3 0.0 2.7 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_23 PF13476.6 EDO16659.1 - 0.00023 21.7 2.4 0.32 11.5 0.0 2.7 2 1 0 2 2 2 2 AAA domain ResIII PF04851.15 EDO16659.1 - 0.00029 20.9 0.0 1.1 9.2 0.0 2.6 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit Bac_DnaA PF00308.18 EDO16659.1 - 0.00031 20.7 0.0 0.11 12.3 0.0 2.9 3 0 0 3 3 3 1 Bacterial dnaA protein DUF2075 PF09848.9 EDO16659.1 - 0.00036 19.9 0.0 0.63 9.2 0.0 2.4 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2075) AAA_30 PF13604.6 EDO16659.1 - 0.00038 20.2 0.0 0.83 9.3 0.0 2.3 2 0 0 2 2 2 2 AAA domain AAA_7 PF12775.7 EDO16659.1 - 0.00044 19.8 0.0 0.078 12.5 0.0 2.4 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_18 PF13238.6 EDO16659.1 - 0.00046 20.7 0.1 0.46 11.0 0.0 2.9 3 0 0 3 3 2 1 AAA domain AAA_11 PF13086.6 EDO16659.1 - 0.001 18.9 0.0 0.53 10.0 0.0 2.5 2 0 0 2 2 2 1 AAA domain TniB PF05621.11 EDO16659.1 - 0.0025 17.3 0.1 3.6 7.0 0.1 3.2 2 1 0 2 2 2 1 Bacterial TniB protein ATPase PF06745.13 EDO16659.1 - 0.004 16.5 1.3 0.28 10.5 0.1 2.9 2 1 1 3 3 3 1 KaiC ATPase_2 PF01637.18 EDO16659.1 - 0.0041 17.1 0.2 2 8.3 0.0 3.2 2 1 1 3 3 3 1 ATPase domain predominantly from Archaea Parvo_NS1 PF01057.17 EDO16659.1 - 0.0064 15.6 0.0 3.1 6.8 0.0 2.3 2 0 0 2 2 2 1 Parvovirus non-structural protein NS1 AAA_19 PF13245.6 EDO16659.1 - 0.0085 16.4 0.0 1.2 9.5 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.6 EDO16659.1 - 0.0088 15.6 0.4 4.7 6.7 0.0 2.9 3 0 0 3 3 3 0 AAA domain DEAD PF00270.29 EDO16659.1 - 0.01 15.6 0.4 13 5.5 0.0 3.8 3 1 1 4 4 4 0 DEAD/DEAH box helicase T2SSE PF00437.20 EDO16659.1 - 0.018 14.1 0.0 3.3 6.7 0.0 2.6 3 0 0 3 3 2 0 Type II/IV secretion system protein AAA_3 PF07726.11 EDO16659.1 - 0.023 14.6 0.0 0.27 11.1 0.0 2.3 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.6 EDO16659.1 - 0.023 14.5 0.3 1.7 8.5 0.0 2.5 2 0 0 2 2 2 0 P-loop containing region of AAA domain Cytidylate_kin PF02224.18 EDO16659.1 - 0.027 14.2 0.1 1.6 8.4 0.0 2.4 2 0 0 2 2 2 0 Cytidylate kinase AAA_28 PF13521.6 EDO16659.1 - 0.032 14.5 0.0 5.6 7.2 0.0 2.4 2 0 0 2 2 2 0 AAA domain Rad17 PF03215.15 EDO16659.1 - 0.062 13.2 0.1 21 5.0 0.0 3.0 2 1 0 2 2 2 0 Rad17 P-loop domain IPT PF01745.16 EDO16659.1 - 0.07 12.5 0.1 0.57 9.5 0.0 2.2 2 0 0 2 2 2 0 Isopentenyl transferase Vps4_C PF09336.10 EDO16659.1 - 0.14 12.1 0.0 0.33 11.0 0.0 1.6 1 0 0 1 1 1 0 Vps4 C terminal oligomerisation domain Zeta_toxin PF06414.12 EDO16659.1 - 0.15 11.3 0.1 4.9 6.4 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin Sigma54_activ_2 PF14532.6 EDO16659.1 - 0.15 12.1 0.0 34 4.5 0.0 2.8 2 0 0 2 2 2 0 Sigma-54 interaction domain Recep_L_domain PF01030.24 EDO16660.1 - 6.6e-08 32.7 7.4 0.14 12.3 1.2 4.8 1 1 3 4 4 4 3 Receptor L domain LRR_9 PF14580.6 EDO16660.1 - 0.00073 19.1 0.6 0.002 17.7 0.6 1.8 1 0 0 1 1 1 1 Leucine-rich repeat Pepsin-I3 PF06394.13 EDO16660.1 - 0.023 14.9 0.0 0.068 13.4 0.0 1.9 1 1 0 1 1 1 0 Pepsin inhibitor-3-like repeated domain Ima1_N PF09779.9 EDO16660.1 - 0.43 11.4 2.1 0.8 10.6 2.1 1.4 1 0 0 1 1 1 0 Ima1 N-terminal domain DUF3617 PF12276.8 EDO16660.1 - 1.5 9.1 6.6 3.1 8.1 6.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3617) zf-C2H2 PF00096.26 EDO16661.1 - 6.1e-11 42.2 12.6 4.6e-06 26.8 2.7 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EDO16661.1 - 1.1e-07 31.9 11.0 3.5e-06 27.2 0.5 2.9 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 EDO16661.1 - 3.3e-07 30.6 10.6 0.0003 21.4 1.8 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger zf-met PF12874.7 EDO16661.1 - 8.4e-05 22.8 6.8 0.00039 20.7 1.1 3.0 2 0 0 2 2 2 1 Zinc-finger of C2H2 type DUF4452 PF14618.6 EDO16661.1 - 0.0028 17.6 8.8 0.0065 16.4 8.8 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4452) zf-C2H2_2 PF12756.7 EDO16661.1 - 0.039 14.3 0.2 0.039 14.3 0.2 2.5 2 1 1 3 3 3 0 C2H2 type zinc-finger (2 copies) ARS2 PF04959.13 EDO16661.1 - 0.083 13.3 0.0 0.23 11.8 0.0 1.7 2 0 0 2 2 2 0 Arsenite-resistance protein 2 zf-C2H2_jaz PF12171.8 EDO16661.1 - 0.13 12.6 0.3 0.13 12.6 0.3 2.5 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.12 EDO16661.1 - 0.24 11.7 1.8 24 5.3 0.2 2.5 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_8 PF15909.5 EDO16661.1 - 0.36 11.2 8.5 0.16 12.3 2.9 2.9 2 1 0 2 2 2 0 C2H2-type zinc ribbon SR-25 PF10500.9 EDO16661.1 - 0.48 10.0 8.0 0.91 9.1 8.0 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein zf-C2H2_6 PF13912.6 EDO16661.1 - 2.2 8.4 5.5 0.44 10.6 1.4 2.0 3 0 0 3 3 3 0 C2H2-type zinc finger DUF3399 PF11879.8 EDO16661.1 - 4.7 7.6 8.2 2 8.8 3.2 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF3399) Peptidase_M28 PF04389.17 EDO16662.1 - 3.1e-36 124.9 0.0 4.8e-36 124.3 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M42 PF05343.14 EDO16662.1 - 0.0027 16.8 0.0 0.0092 15.0 0.0 1.8 2 0 0 2 2 2 1 M42 glutamyl aminopeptidase Peptidase_M20 PF01546.28 EDO16662.1 - 0.011 15.4 0.0 0.013 15.2 0.0 1.3 1 0 0 1 1 1 0 Peptidase family M20/M25/M40 bVLRF1 PF18826.1 EDO16663.1 - 4.5e-58 195.4 0.1 1e-57 194.2 0.1 1.6 1 0 0 1 1 1 1 bacteroidetes VLRF1 release factor Ank_5 PF13857.6 EDO16663.1 - 2.6e-05 24.4 0.0 0.00021 21.5 0.0 2.2 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.30 EDO16663.1 - 0.071 13.6 0.0 0.2 12.2 0.0 1.8 1 0 0 1 1 1 0 Ankyrin repeat Ank_2 PF12796.7 EDO16663.1 - 0.083 13.5 0.0 0.17 12.5 0.0 1.5 1 0 0 1 1 1 0 Ankyrin repeats (3 copies) FHA_2 PF17913.1 EDO16663.1 - 0.11 12.7 0.9 0.3 11.4 0.1 2.2 2 0 0 2 2 2 0 FHA domain Alg14 PF08660.11 EDO16664.1 - 4.5e-54 183.0 0.1 6.7e-54 182.5 0.1 1.3 1 0 0 1 1 1 1 Oligosaccharide biosynthesis protein Alg14 like DUF2976 PF11190.8 EDO16664.1 - 0.5 10.2 2.6 8.8 6.2 0.0 2.9 3 1 0 3 3 3 0 Protein of unknown function (DUF2976) His_Phos_1 PF00300.22 EDO16665.1 - 4.8e-14 52.5 0.0 6.3e-14 52.1 0.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) His_Phos_1 PF00300.22 EDO16666.1 - 3.4e-10 39.9 0.0 4.3e-06 26.5 0.0 2.1 2 0 0 2 2 2 2 Histidine phosphatase superfamily (branch 1) Thioredoxin_8 PF13905.6 EDO16667.1 - 0.027 14.8 0.1 0.098 13.0 0.1 2.1 1 1 0 1 1 1 0 Thioredoxin-like Thioredoxin PF00085.20 EDO16667.1 - 0.13 12.3 0.0 0.21 11.6 0.0 1.5 1 1 0 1 1 1 0 Thioredoxin AA_permease PF00324.21 EDO16668.1 - 2.3e-123 412.3 40.5 2.8e-123 412.0 40.5 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EDO16668.1 - 2.9e-34 118.7 41.7 3.4e-34 118.4 41.7 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EDO16669.1 - 3.1e-122 408.6 37.9 4e-122 408.2 37.9 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EDO16669.1 - 4e-30 105.0 38.1 5e-30 104.7 38.1 1.1 1 0 0 1 1 1 1 Amino acid permease DUF4147 PF13660.6 EDO16669.1 - 0.055 13.0 0.1 0.1 12.2 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4147) Pet100 PF09803.9 EDO16669.1 - 0.1 13.2 0.5 0.25 11.9 0.5 1.7 1 0 0 1 1 1 0 Pet100 Coprogen_oxidas PF01218.18 EDO16670.1 - 1.8e-128 427.4 0.2 2.1e-128 427.2 0.2 1.0 1 0 0 1 1 1 1 Coproporphyrinogen III oxidase zf-C2H2 PF00096.26 EDO16671.1 - 0.00016 21.9 14.9 0.0021 18.4 1.1 3.0 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EDO16671.1 - 0.00061 20.1 3.2 0.00061 20.1 3.2 3.2 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 EDO16671.1 - 0.0013 19.4 11.9 0.044 14.6 0.7 2.9 2 0 0 2 2 2 2 C2H2-type zinc finger zf-met PF12874.7 EDO16671.1 - 0.024 15.0 5.3 0.15 12.5 0.2 3.1 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-RING_2 PF13639.6 EDO16672.1 - 1.6e-10 41.2 11.7 2.6e-10 40.4 11.7 1.4 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 EDO16672.1 - 3.6e-08 33.6 10.3 7.7e-08 32.5 10.3 1.6 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 EDO16672.1 - 6.8e-06 26.1 4.6 1.1e-05 25.4 4.6 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.6 EDO16672.1 - 1e-05 25.5 8.5 1e-05 25.4 6.7 1.9 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.25 EDO16672.1 - 1.2e-05 25.1 12.7 2.1e-05 24.3 12.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EDO16672.1 - 3.9e-05 23.4 9.8 7.7e-05 22.5 9.8 1.5 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EDO16672.1 - 0.00032 20.5 12.7 0.00073 19.3 12.7 1.6 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EDO16672.1 - 0.005 16.8 10.1 0.0088 16.0 10.1 1.4 1 0 0 1 1 1 1 zinc-RING finger domain FANCL_C PF11793.8 EDO16672.1 - 0.0069 16.5 9.0 0.16 12.2 9.0 2.2 1 1 0 1 1 1 1 FANCL C-terminal domain zf-RING_11 PF17123.5 EDO16672.1 - 0.0092 15.7 7.1 0.0092 15.7 7.1 2.1 2 0 0 2 2 2 1 RING-like zinc finger Prok-RING_4 PF14447.6 EDO16672.1 - 0.13 12.1 10.4 0.38 10.6 10.4 1.8 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 UPF0547 PF10571.9 EDO16672.1 - 1.8 8.7 9.9 11 6.2 0.1 2.8 2 1 0 2 2 2 0 Uncharacterised protein family UPF0547 E1-E2_ATPase PF00122.20 EDO16673.1 - 6.8e-37 126.7 20.8 1.1e-32 113.1 0.1 3.6 4 0 0 4 4 4 2 E1-E2 ATPase Cation_ATPase_C PF00689.21 EDO16673.1 - 9.8e-30 103.6 2.0 9.8e-30 103.6 2.0 2.7 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 EDO16673.1 - 9.3e-21 75.1 0.0 1.3e-16 61.5 0.0 2.5 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EDO16673.1 - 9.5e-21 73.7 0.0 1.9e-20 72.7 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 EDO16673.1 - 1.9e-11 43.5 0.1 6.4e-11 41.8 0.0 2.1 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 EDO16673.1 - 0.00022 21.1 0.5 0.0032 17.2 0.8 2.4 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase tRNA-synt_2 PF00152.20 EDO16674.1 - 2.7e-75 253.4 0.2 3.7e-75 252.9 0.2 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 EDO16674.1 - 1.1e-12 47.8 0.7 5.1e-12 45.6 0.4 2.1 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 EDO16674.1 - 5.3e-07 29.4 0.0 0.0037 16.8 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) DnaJ PF00226.31 EDO16674.1 - 0.082 13.0 0.0 1.1 9.4 0.0 2.5 2 0 0 2 2 2 0 DnaJ domain Pkinase PF00069.25 EDO16675.1 - 9.1e-36 123.6 0.1 1.9e-35 122.5 0.1 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO16675.1 - 2.8e-21 76.0 0.0 4.2e-21 75.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EDO16675.1 - 0.0081 16.1 0.0 0.5 10.2 0.0 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family MAS20 PF02064.15 EDO16675.1 - 0.26 11.4 1.9 0.91 9.6 1.9 2.0 1 0 0 1 1 1 0 MAS20 protein import receptor Wtap PF17098.5 EDO16677.1 - 2.2e-08 34.2 12.5 1.6e-07 31.4 8.1 2.2 1 1 1 2 2 2 2 WTAP/Mum2p family YchF-GTPase_C PF06071.13 EDO16678.1 - 1.5e-30 105.2 0.1 3.5e-30 104.0 0.1 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF933) MMR_HSR1 PF01926.23 EDO16678.1 - 1.4e-17 63.8 0.0 4.6e-17 62.1 0.0 1.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase TGS PF02824.21 EDO16678.1 - 1.1e-06 28.6 0.0 2.1e-06 27.7 0.0 1.4 1 0 0 1 1 1 1 TGS domain FeoB_N PF02421.18 EDO16678.1 - 0.0018 17.8 0.0 0.004 16.7 0.0 1.6 1 0 0 1 1 1 1 Ferrous iron transport protein B OTU PF02338.19 EDO16679.1 - 2.8e-24 86.0 0.1 2.8e-24 86.0 0.1 2.0 3 0 0 3 3 3 1 OTU-like cysteine protease NifT PF06988.11 EDO16679.1 - 0.33 10.8 1.7 0.49 10.2 0.2 1.9 2 0 0 2 2 2 0 NifT/FixU protein DUF2521 PF10730.9 EDO16679.1 - 0.64 10.0 4.5 2.3 8.3 0.7 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF2521) CHCH PF06747.13 EDO16680.1 - 5e-08 32.9 4.1 9.4e-08 32.0 4.1 1.5 1 0 0 1 1 1 1 CHCH domain GCK PF07802.11 EDO16680.1 - 0.053 13.9 4.9 0.1 13.0 4.9 1.5 1 0 0 1 1 1 0 GCK domain G-patch PF01585.23 EDO16681.1 - 2.3e-13 49.8 2.6 4.1e-13 49.0 2.6 1.4 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 EDO16681.1 - 4e-06 26.8 0.3 8.8e-06 25.7 0.3 1.6 1 0 0 1 1 1 1 G-patch domain DUF4484 PF14831.6 EDO16681.1 - 0.02 14.9 0.8 0.045 13.8 0.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4484) Phage_min_cap2 PF06152.11 EDO16681.1 - 0.063 12.2 1.6 0.12 11.2 1.6 1.4 1 0 0 1 1 1 0 Phage minor capsid protein 2 APG17 PF04108.12 EDO16682.1 - 1.9e-92 310.4 10.2 2.2e-92 310.2 10.2 1.0 1 0 0 1 1 1 1 Autophagy protein Apg17 Baculo_PEP_C PF04513.12 EDO16682.1 - 0.0017 18.4 0.2 0.0017 18.4 0.2 3.6 2 1 2 4 4 4 1 Baculovirus polyhedron envelope protein, PEP, C terminus DUF4795 PF16043.5 EDO16682.1 - 0.0018 17.9 5.5 0.0096 15.5 2.4 2.5 1 1 1 2 2 2 1 Domain of unknown function (DUF4795) MutS_III PF05192.18 EDO16682.1 - 0.047 13.9 7.7 0.023 15.0 1.5 2.4 1 1 1 2 2 2 0 MutS domain III NPV_P10 PF05531.12 EDO16682.1 - 0.063 13.8 5.7 5 7.7 0.2 4.0 3 1 0 3 3 3 0 Nucleopolyhedrovirus P10 protein LOH1CR12 PF10158.9 EDO16682.1 - 1.5 8.8 4.7 6.8 6.7 0.2 3.4 3 2 1 4 4 4 0 Tumour suppressor protein UPF0113_N PF17833.1 EDO16682.1 - 7.9 7.1 8.3 1.4 9.5 0.8 3.2 3 0 0 3 3 3 0 UPF0113 Pre-PUA domain tRNA-synt_2b PF00587.25 EDO16683.1 - 2.2e-45 154.8 0.0 3.3e-45 154.2 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 EDO16683.1 - 1.4e-14 54.0 0.0 2.5e-14 53.2 0.0 1.4 1 0 0 1 1 1 1 Anticodon binding domain RuBisCO_small PF00101.20 EDO16683.1 - 0.27 11.3 1.4 0.66 10.0 0.1 2.1 2 0 0 2 2 2 0 Ribulose bisphosphate carboxylase, small chain PP-binding PF00550.25 EDO16684.1 - 8.5e-13 48.5 0.1 1.1e-12 48.1 0.1 1.2 1 0 0 1 1 1 1 Phosphopantetheine attachment site PP-binding_2 PF14573.6 EDO16684.1 - 6.2e-07 29.6 0.5 7.6e-07 29.3 0.5 1.3 1 0 0 1 1 1 1 Acyl-carrier DOCK_N PF16172.5 EDO16685.1 - 1.2e-06 27.8 0.1 0.00044 19.3 0.0 2.0 2 0 0 2 2 2 2 DOCK N-terminus Proteasom_Rpn13 PF04683.13 EDO16686.1 - 2e-20 73.1 0.0 3.1e-20 72.5 0.0 1.3 1 0 0 1 1 1 1 Proteasome complex subunit Rpn13 ubiquitin receptor FAM176 PF14851.6 EDO16686.1 - 5.7 6.6 7.0 8.3 6.1 7.0 1.3 1 0 0 1 1 1 0 FAM176 family Cwf_Cwc_15 PF04889.12 EDO16686.1 - 7.2 6.3 13.3 9.7 5.8 13.3 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Diphthamide_syn PF01866.17 EDO16687.1 - 1.8e-66 224.6 0.3 3e-66 223.9 0.3 1.4 1 0 0 1 1 1 1 Putative diphthamide synthesis protein DUF1509 PF07420.11 EDO16687.1 - 0.065 12.2 0.0 0.11 11.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1509) EF-hand_1 PF00036.32 EDO16688.1 - 8.1e-25 84.5 12.4 1.2e-05 24.5 0.5 4.3 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 EDO16688.1 - 4.7e-22 78.2 7.7 1.6e-13 50.9 1.2 2.7 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EDO16688.1 - 2.9e-20 70.4 6.3 0.00015 21.4 0.2 4.4 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 EDO16688.1 - 1.4e-16 59.1 13.3 0.00054 19.3 0.2 4.5 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 EDO16688.1 - 1.8e-10 40.5 10.8 0.052 13.4 0.1 4.3 4 0 0 4 4 4 4 EF-hand domain pair EF-hand_4 PF12763.7 EDO16688.1 - 1.7e-06 27.9 10.7 0.026 14.5 0.3 4.0 1 1 3 4 4 4 3 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 EDO16688.1 - 4.9e-06 26.8 0.1 0.14 12.5 0.0 2.4 2 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.6 EDO16688.1 - 0.00022 21.5 0.1 1.6 9.1 0.0 3.0 2 1 1 3 3 3 2 EF-hand domain DUF2205 PF10224.9 EDO16689.1 - 1.3e-08 34.7 3.4 1.4e-08 34.6 3.4 1.1 1 0 0 1 1 1 1 Short coiled-coil protein RBD-FIP PF09457.10 EDO16689.1 - 0.01 15.7 1.7 0.01 15.7 1.7 1.9 1 1 1 2 2 2 0 FIP domain RasGAP_C PF03836.15 EDO16689.1 - 0.036 14.2 2.7 0.049 13.8 2.7 1.1 1 0 0 1 1 1 0 RasGAP C-terminus Serinc PF03348.15 EDO16690.1 - 1.6e-138 462.3 17.1 1.9e-138 462.0 17.1 1.0 1 0 0 1 1 1 1 Serine incorporator (Serinc) TMEM173 PF15009.6 EDO16690.1 - 2.2 7.4 8.3 0.2 10.8 3.2 1.8 2 0 0 2 2 2 0 Transmembrane protein 173 Rad51 PF08423.11 EDO16691.1 - 1.1e-113 378.8 0.0 1.4e-113 378.4 0.0 1.1 1 0 0 1 1 1 1 Rad51 RecA PF00154.21 EDO16691.1 - 1.6e-10 40.9 0.1 2.2e-10 40.4 0.1 1.2 1 0 0 1 1 1 1 recA bacterial DNA recombination protein ATPase PF06745.13 EDO16691.1 - 1.9e-07 30.7 0.1 4.9e-07 29.3 0.1 1.8 1 1 0 1 1 1 1 KaiC AAA_25 PF13481.6 EDO16691.1 - 5.4e-07 29.4 0.0 7.7e-07 28.9 0.0 1.2 1 0 0 1 1 1 1 AAA domain HHH_5 PF14520.6 EDO16691.1 - 8.3e-05 23.1 0.8 0.00022 21.8 0.3 1.9 2 0 0 2 2 2 1 Helix-hairpin-helix domain PAXNEB PF05625.11 EDO16691.1 - 0.094 11.8 0.1 0.21 10.7 0.1 1.5 2 0 0 2 2 2 0 PAXNEB protein RNA_pol_A_CTD PF03118.15 EDO16691.1 - 0.1 12.4 0.3 0.26 11.1 0.3 1.7 1 0 0 1 1 1 0 Bacterial RNA polymerase, alpha chain C terminal domain PH_4 PF15404.6 EDO16692.1 - 9.7e-63 211.3 0.2 9.7e-63 211.3 0.2 1.9 2 0 0 2 2 2 1 Pleckstrin homology domain Spo7_2_N PF15407.6 EDO16692.1 - 1.8e-19 69.1 1.2 2.9e-19 68.5 0.0 2.1 2 0 0 2 2 2 1 Sporulation protein family 7 PH_13 PF16652.5 EDO16692.1 - 0.64 9.8 4.7 6.6 6.5 0.1 3.3 3 0 0 3 3 3 0 Pleckstrin homology domain E1_dh PF00676.20 EDO16693.1 - 2.5e-121 404.3 0.0 3e-121 404.0 0.0 1.0 1 0 0 1 1 1 1 Dehydrogenase E1 component DXP_synthase_N PF13292.6 EDO16693.1 - 0.033 13.4 0.0 0.051 12.8 0.0 1.2 1 0 0 1 1 1 0 1-deoxy-D-xylulose-5-phosphate synthase COPI_assoc PF08507.10 EDO16694.1 - 2.7e-25 88.9 10.0 3e-25 88.8 10.0 1.0 1 0 0 1 1 1 1 COPI associated protein 14-3-3 PF00244.20 EDO16695.1 - 1.6e-99 331.9 3.2 1.8e-99 331.7 3.2 1.0 1 0 0 1 1 1 1 14-3-3 protein MitMem_reg PF13012.6 EDO16695.1 - 0.024 15.0 1.2 0.051 14.0 1.2 1.8 1 1 0 1 1 1 0 Maintenance of mitochondrial structure and function FlaF PF07309.11 EDO16695.1 - 0.028 14.5 0.4 0.062 13.3 0.4 1.6 1 0 0 1 1 1 0 Flagellar protein FlaF MCM6_C PF18263.1 EDO16695.1 - 0.92 9.8 6.9 0.71 10.1 0.7 2.4 2 0 0 2 2 2 0 MCM6 C-terminal winged-helix domain tRNA-synt_2 PF00152.20 EDO16696.1 - 2.7e-64 217.2 0.0 3.8e-64 216.8 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 EDO16696.1 - 1.7e-06 27.9 0.0 3.5e-06 26.9 0.0 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 EDO16696.1 - 2.1e-05 24.1 0.1 0.0031 17.0 0.0 2.4 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) RNase_HII PF01351.18 EDO16697.1 - 4.5e-65 219.2 0.0 5.7e-65 218.9 0.0 1.1 1 0 0 1 1 1 1 Ribonuclease HII DUF1138 PF06592.13 EDO16697.1 - 0.1 12.7 0.0 0.32 11.1 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1138) Tom7 PF08038.12 EDO16698.1 - 4.9e-21 74.1 0.3 6e-21 73.8 0.3 1.1 1 0 0 1 1 1 1 TOM7 family Ribosomal_L13 PF00572.18 EDO16699.1 - 3.9e-11 43.3 1.2 1.9e-09 37.8 0.1 2.5 2 1 0 2 2 2 1 Ribosomal protein L13 CSM2 PF16834.5 EDO16700.1 - 2.4e-75 252.6 6.3 2.8e-75 252.4 6.3 1.0 1 0 0 1 1 1 1 Shu complex component Csm2, DNA-binding COX7B PF05392.11 EDO16700.1 - 0.0041 16.8 0.0 0.0073 16.0 0.0 1.4 1 0 0 1 1 1 1 Cytochrome C oxidase chain VIIB Forkhead PF00250.18 EDO16701.1 - 7.8e-34 115.8 0.4 2.9e-33 114.0 0.4 2.1 1 0 0 1 1 1 1 Forkhead domain FHA PF00498.26 EDO16701.1 - 4.1e-11 43.1 0.1 1.3e-10 41.5 0.1 1.9 1 0 0 1 1 1 1 FHA domain MOR2-PAG1_N PF14222.6 EDO16702.1 - 4.8e-177 590.3 5.0 4.8e-177 590.3 5.0 2.1 2 0 0 2 2 2 1 Cell morphogenesis N-terminal MOR2-PAG1_C PF14225.6 EDO16702.1 - 2.2e-90 302.9 0.8 1.1e-89 300.6 1.1 2.2 2 0 0 2 2 2 1 Cell morphogenesis C-terminal MOR2-PAG1_mid PF14228.6 EDO16702.1 - 2.2e-21 75.3 19.9 3.2e-09 35.1 1.1 3.8 2 2 1 3 3 3 3 Cell morphogenesis central region RPAP3_C PF13877.6 EDO16702.1 - 0.49 11.0 10.5 28 5.4 0.1 5.1 4 0 0 4 4 4 0 Potential Monad-binding region of RPAP3 Ribosomal_L6 PF00347.23 EDO16703.1 - 4.1e-15 56.2 0.4 4.8e-15 56.0 0.4 1.1 1 0 0 1 1 1 1 Ribosomal protein L6 YfhD PF14151.6 EDO16703.1 - 0.11 12.7 0.0 0.34 11.1 0.0 1.8 2 0 0 2 2 2 0 YfhD-like protein SUN PF03856.13 EDO16704.1 - 2.1e-97 325.4 17.1 2.1e-97 325.4 17.1 1.9 2 0 0 2 2 1 1 Beta-glucosidase (SUN family) DDHD PF02862.17 EDO16704.1 - 0.0032 17.7 4.3 0.0043 17.2 4.3 1.3 1 0 0 1 1 1 1 DDHD domain PAP1 PF08601.10 EDO16704.1 - 0.033 13.9 27.1 0.052 13.3 27.1 1.3 1 0 0 1 1 1 0 Transcription factor PAP1 AF-4 PF05110.13 EDO16704.1 - 0.043 11.9 19.1 0.067 11.3 19.1 1.3 1 0 0 1 1 1 0 AF-4 proto-oncoprotein PAT1 PF09770.9 EDO16704.1 - 0.07 11.4 15.3 0.096 11.0 15.3 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Macoilin PF09726.9 EDO16704.1 - 0.083 11.4 16.6 0.1 11.1 16.6 1.1 1 0 0 1 1 1 0 Macoilin family SPX PF03105.19 EDO16704.1 - 0.094 12.6 11.5 0.12 12.3 11.5 1.1 1 0 0 1 1 1 0 SPX domain SLC12 PF03522.15 EDO16704.1 - 0.18 10.8 10.5 0.16 10.9 9.6 1.4 2 0 0 2 2 1 0 Solute carrier family 12 RR_TM4-6 PF06459.12 EDO16704.1 - 0.18 11.6 12.1 0.24 11.2 12.1 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 TFIIA PF03153.13 EDO16704.1 - 0.33 10.9 28.7 0.44 10.5 28.7 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Apt1 PF10351.9 EDO16704.1 - 0.44 9.4 12.5 0.56 9.0 12.5 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain DUF853 PF05872.12 EDO16704.1 - 0.45 9.0 9.1 0.61 8.6 9.1 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) DUF2052 PF09747.9 EDO16704.1 - 0.66 10.1 8.8 0.97 9.5 8.8 1.3 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Zip PF02535.22 EDO16704.1 - 0.72 9.0 3.8 0.93 8.6 3.8 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter SR-25 PF10500.9 EDO16704.1 - 0.81 9.2 20.5 1.3 8.6 20.5 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF572 PF04502.13 EDO16704.1 - 0.87 9.1 18.2 1.3 8.6 18.2 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) Dehydrin PF00257.19 EDO16704.1 - 1.1 9.8 22.4 3.2 8.3 22.4 1.8 1 0 0 1 1 1 0 Dehydrin GREB1 PF15782.5 EDO16704.1 - 1.3 6.1 22.3 1.6 5.7 22.3 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Presenilin PF01080.17 EDO16704.1 - 1.3 7.7 18.7 1.8 7.3 18.7 1.1 1 0 0 1 1 1 0 Presenilin SAPS PF04499.15 EDO16704.1 - 1.7 7.3 10.1 2.2 7.0 10.1 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein API5 PF05918.11 EDO16704.1 - 1.9 7.2 11.2 2.6 6.8 11.2 1.2 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) Band_3_cyto PF07565.13 EDO16704.1 - 2 8.1 8.5 3.4 7.4 8.5 1.4 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Otopetrin PF03189.13 EDO16704.1 - 2.1 7.1 5.6 2.7 6.7 5.6 1.2 1 0 0 1 1 1 0 Otopetrin Coilin_N PF15862.5 EDO16704.1 - 2.2 8.1 10.6 4.5 7.1 10.6 1.6 1 0 0 1 1 1 0 Coilin N-terminus CSG2 PF16965.5 EDO16704.1 - 2.7 6.9 6.3 3.5 6.5 6.3 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator Hydin_ADK PF17213.3 EDO16704.1 - 3.5 7.9 17.6 5.6 7.2 17.6 1.4 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain CPSF100_C PF13299.6 EDO16704.1 - 3.7 7.7 12.9 6 7.0 12.9 1.3 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Lin-8 PF03353.15 EDO16704.1 - 5.6 6.4 16.9 7.9 5.9 16.9 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Hid1 PF12722.7 EDO16704.1 - 5.7 4.9 16.4 7.5 4.5 16.4 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Plasmodium_Vir PF05795.11 EDO16704.1 - 6.6 6.0 12.0 9.8 5.5 12.0 1.2 1 0 0 1 1 1 0 Plasmodium vivax Vir protein PPP4R2 PF09184.11 EDO16704.1 - 6.9 6.2 15.5 9.9 5.7 15.5 1.2 1 0 0 1 1 1 0 PPP4R2 Sporozoite_P67 PF05642.11 EDO16704.1 - 7 4.6 20.7 11 4.0 20.7 1.3 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Membralin PF09746.9 EDO16704.1 - 7.2 5.5 7.3 12 4.8 7.3 1.3 1 0 0 1 1 1 0 Tumour-associated protein SOG2 PF10428.9 EDO16704.1 - 7.5 5.6 24.8 9.9 5.2 24.8 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein Neur_chan_memb PF02932.16 EDO16704.1 - 7.9 6.5 9.4 12 5.9 9.4 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Peptidase_S64 PF08192.11 EDO16704.1 - 7.9 4.8 17.8 11 4.4 17.8 1.1 1 0 0 1 1 1 0 Peptidase family S64 Tim54 PF11711.8 EDO16704.1 - 8 5.1 12.7 12 4.6 12.7 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF1387 PF07139.11 EDO16704.1 - 8 6.1 16.1 11 5.7 16.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) DUF913 PF06025.12 EDO16704.1 - 8.2 5.3 11.3 11 4.9 11.3 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) NST1 PF13945.6 EDO16704.1 - 8.6 6.4 18.0 15 5.6 18.0 1.3 1 0 0 1 1 1 0 Salt tolerance down-regulator PP_M1 PF03012.14 EDO16704.1 - 9.1 5.7 10.4 17 4.8 10.4 1.5 1 0 0 1 1 1 0 Phosphoprotein DUF4603 PF15376.6 EDO16704.1 - 9.2 3.5 23.3 2.4 5.5 20.4 1.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4603) DUF2087 PF09860.9 EDO16705.1 - 0.13 12.5 0.0 0.31 11.2 0.0 1.7 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2087) Menin PF05053.13 EDO16705.1 - 6.9 4.9 9.7 9.4 4.5 9.7 1.2 1 0 0 1 1 1 0 Menin MFS_1 PF07690.16 EDO16706.1 - 4.2e-41 141.1 27.6 1.1e-39 136.4 14.4 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EDO16706.1 - 5.3e-12 45.4 25.1 3e-10 39.6 16.5 2.5 2 1 1 3 3 3 2 Sugar (and other) transporter TRI12 PF06609.13 EDO16706.1 - 0.00062 18.3 6.0 0.0011 17.5 6.0 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Fer2_2 PF01799.20 EDO16706.1 - 0.1 12.6 0.3 0.23 11.5 0.3 1.5 1 0 0 1 1 1 0 [2Fe-2S] binding domain Gly-zipper_OmpA PF13436.6 EDO16706.1 - 0.18 11.6 1.9 0.42 10.4 1.9 1.6 1 0 0 1 1 1 0 Glycine-zipper domain Gly-zipper_Omp PF13488.6 EDO16706.1 - 0.21 11.6 4.1 0.43 10.6 4.1 1.5 1 0 0 1 1 1 0 Glycine zipper MFS_1_like PF12832.7 EDO16706.1 - 3.6 6.4 13.2 2.1 7.1 9.4 2.2 1 1 0 1 1 1 0 MFS_1 like family DnaJ_C PF01556.18 EDO16707.1 - 2.4e-38 131.5 0.5 3.3e-38 131.1 0.5 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 EDO16707.1 - 1e-25 89.6 0.5 1.6e-25 89.0 0.5 1.3 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 EDO16707.1 - 2.8e-15 56.4 18.3 2.8e-15 56.4 18.3 1.7 2 0 0 2 2 2 1 DnaJ central domain Anti-TRAP PF15777.5 EDO16707.1 - 0.037 14.0 2.4 0.037 14.0 2.4 2.7 2 1 1 3 3 3 0 Tryptophan RNA-binding attenuator protein inhibitory protein HypA PF01155.19 EDO16707.1 - 0.37 10.8 10.3 1.9 8.5 1.4 2.5 1 1 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Cytochrome_C7 PF14522.6 EDO16707.1 - 3.1 7.9 6.6 1.7 8.7 3.6 2.1 1 1 1 2 2 2 0 Cytochrome c7 and related cytochrome c MTS PF05175.14 EDO16708.1 - 1.3e-07 31.4 0.0 2.3e-07 30.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.6 EDO16708.1 - 0.00071 20.2 0.0 0.0016 19.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain AviRa PF11599.8 EDO16708.1 - 0.0019 17.7 0.1 0.0038 16.7 0.1 1.4 1 0 0 1 1 1 1 RRNA methyltransferase AviRa N6_Mtase PF02384.16 EDO16708.1 - 0.005 16.1 0.1 0.0071 15.7 0.1 1.2 1 0 0 1 1 1 1 N-6 DNA Methylase Methyltransf_32 PF13679.6 EDO16708.1 - 0.013 15.5 0.0 0.022 14.8 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.6 EDO16708.1 - 0.014 15.2 0.1 0.019 14.7 0.1 1.3 1 0 0 1 1 1 0 Methyltransferase domain TctC PF03401.14 EDO16708.1 - 0.1 11.6 0.0 0.15 11.1 0.0 1.2 1 0 0 1 1 1 0 Tripartite tricarboxylate transporter family receptor Gcd10p PF04189.13 EDO16709.1 - 2.3e-105 352.0 4.6 3.1e-105 351.6 4.6 1.2 1 0 0 1 1 1 1 Gcd10p family Iwr1 PF08574.10 EDO16709.1 - 0.46 11.5 3.8 1.3 10.0 3.8 1.7 1 0 0 1 1 1 0 Transcription factor Iwr1 Methyltr_RsmB-F PF01189.17 EDO16710.1 - 4.2e-81 271.4 0.1 1.1e-80 270.0 0.0 1.8 2 0 0 2 2 2 1 16S rRNA methyltransferase RsmB/F Methyltr_RsmF_N PF17125.5 EDO16710.1 - 2.1e-08 34.5 0.0 8.6e-08 32.6 0.0 2.1 1 0 0 1 1 1 1 N-terminal domain of 16S rRNA methyltransferase RsmF FtsJ PF01728.19 EDO16710.1 - 0.017 15.3 0.0 0.036 14.2 0.0 1.5 1 0 0 1 1 1 0 FtsJ-like methyltransferase Bradykinin PF06753.12 EDO16710.1 - 0.71 9.6 2.1 1.5 8.6 2.1 1.5 1 0 0 1 1 1 0 Bradykinin DDHD PF02862.17 EDO16710.1 - 4.9 7.3 11.4 1.6 8.8 7.9 2.1 2 0 0 2 2 2 0 DDHD domain NPR3 PF03666.13 EDO16710.1 - 5.8 5.6 20.7 9.4 4.9 20.7 1.4 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 BAF1_ABF1 PF04684.13 EDO16710.1 - 7.3 5.5 28.8 13 4.7 28.8 1.3 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Actin PF00022.19 EDO16711.1 - 1.1e-47 162.5 0.0 3.4e-26 91.8 0.0 2.7 2 2 1 3 3 3 2 Actin Caldesmon PF02029.15 EDO16711.1 - 0.012 14.4 37.1 0.023 13.5 37.1 1.4 1 0 0 1 1 1 0 Caldesmon Peptidase_M60 PF13402.6 EDO16711.1 - 0.018 14.6 1.0 0.042 13.4 1.0 1.6 1 0 0 1 1 1 0 Peptidase M60, enhancin and enhancin-like Y_phosphatase2 PF03162.13 EDO16713.1 - 3.9e-52 176.1 0.0 4.6e-52 175.9 0.0 1.0 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.6 EDO16713.1 - 9.9e-06 25.7 0.0 1.2e-05 25.4 0.0 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family Porin_3 PF01459.22 EDO16714.1 - 7.7e-67 225.6 11.6 8.6e-67 225.4 11.6 1.0 1 0 0 1 1 1 1 Eukaryotic porin DASH_Dad4 PF08650.10 EDO16714.1 - 0.25 11.3 1.2 0.79 9.7 0.1 2.5 3 0 0 3 3 3 0 DASH complex subunit Dad4 COG5 PF10392.9 EDO16715.1 - 1.8e-32 112.3 8.0 1.8e-32 112.3 8.0 3.1 2 1 1 3 3 3 1 Golgi transport complex subunit 5 DUF2011 PF09428.10 EDO16716.1 - 2.4e-20 72.6 0.1 4.9e-20 71.6 0.1 1.6 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF2011) Flu_B_M2 PF04772.12 EDO16716.1 - 0.13 12.5 0.6 0.26 11.5 0.1 1.7 1 1 0 1 1 1 0 Influenza B matrix protein 2 (BM2) LicD PF04991.13 EDO16716.1 - 3.6 7.7 11.6 1.1 9.3 8.3 1.7 2 0 0 2 2 2 0 LicD family FctA PF12892.7 EDO16716.1 - 4.8 8.0 11.1 1.4 9.8 7.7 1.8 1 1 0 1 1 1 0 Spy0128-like isopeptide containing domain Sec23_trunk PF04811.15 EDO16717.1 - 5.1e-72 242.3 0.1 2e-71 240.4 0.0 2.0 2 0 0 2 2 2 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.15 EDO16717.1 - 1e-21 76.7 0.1 2.7e-21 75.3 0.1 1.8 1 0 0 1 1 1 1 Sec23/Sec24 helical domain zf-Sec23_Sec24 PF04810.15 EDO16717.1 - 1.2e-16 60.5 3.7 2.5e-16 59.4 3.7 1.6 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Sec23_BS PF08033.12 EDO16717.1 - 1.1e-15 58.1 0.1 1.1e-15 58.1 0.1 2.3 3 0 0 3 3 3 1 Sec23/Sec24 beta-sandwich domain Gelsolin PF00626.22 EDO16717.1 - 8.2e-09 35.2 0.0 2.5e-08 33.7 0.0 1.9 1 0 0 1 1 1 1 Gelsolin repeat Metallopep PF12044.8 EDO16718.1 - 1.4e-178 593.9 0.0 2e-178 593.4 0.0 1.2 1 0 0 1 1 1 1 Putative peptidase family Jacalin PF01419.17 EDO16718.1 - 8e-05 22.6 0.0 0.00016 21.6 0.0 1.5 1 0 0 1 1 1 1 Jacalin-like lectin domain Reprolysin_5 PF13688.6 EDO16718.1 - 0.013 15.7 0.0 0.02 15.1 0.0 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12 Reprolysin_3 PF13582.6 EDO16718.1 - 0.013 16.0 0.2 0.053 14.0 0.1 2.0 2 0 0 2 2 2 0 Metallo-peptidase family M12B Reprolysin-like Peptidase_M10 PF00413.24 EDO16718.1 - 0.034 14.0 0.1 0.064 13.1 0.1 1.6 1 1 0 1 1 1 0 Matrixin 6PF2K PF01591.18 EDO16719.1 - 1.6e-77 259.8 0.1 1.6e-77 259.8 0.1 2.6 3 0 0 3 3 3 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 EDO16719.1 - 1.9e-33 115.8 0.0 7.9e-28 97.5 0.0 2.2 2 0 0 2 2 2 2 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.6 EDO16719.1 - 3.3e-07 30.6 0.0 6.8e-07 29.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EDO16719.1 - 0.00021 21.8 0.2 0.00071 20.1 0.0 2.0 2 0 0 2 2 2 1 AAA domain APS_kinase PF01583.20 EDO16719.1 - 0.0015 18.5 0.0 0.0032 17.4 0.0 1.5 1 0 0 1 1 1 1 Adenylylsulphate kinase KTI12 PF08433.10 EDO16719.1 - 0.0035 16.8 0.0 0.0089 15.5 0.0 1.7 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_17 PF13207.6 EDO16719.1 - 0.018 15.5 0.0 0.055 13.9 0.0 1.9 1 0 0 1 1 1 0 AAA domain Pox_A28 PF04584.14 EDO16719.1 - 0.15 12.3 1.3 0.38 11.0 0.0 2.3 2 0 0 2 2 2 0 Poxvirus A28 family DUF2722 PF10846.8 EDO16720.1 - 1.5e-67 228.6 29.1 1.4e-63 215.5 29.1 3.9 1 1 0 1 1 1 1 Protein of unknown function (DUF2722) SHQ1 PF04925.15 EDO16721.1 - 1.9e-71 239.3 1.1 3.2e-71 238.5 1.1 1.4 1 0 0 1 1 1 1 SHQ1 protein Diphthamide_syn PF01866.17 EDO16722.1 - 1e-114 383.1 0.1 1.2e-114 382.8 0.1 1.1 1 0 0 1 1 1 1 Putative diphthamide synthesis protein Ada3 PF10198.9 EDO16723.1 - 6.9 6.8 8.8 13 5.9 2.4 2.6 2 0 0 2 2 2 0 Histone acetyltransferases subunit 3 Pro_CA PF00484.19 EDO16724.1 - 7.4e-36 123.8 0.1 9.9e-36 123.4 0.1 1.2 1 0 0 1 1 1 1 Carbonic anhydrase Complex1_LYR_2 PF13233.6 EDO16725.1 - 4.9e-16 59.2 3.5 1.8e-15 57.4 3.5 1.8 1 1 0 1 1 1 1 Complex1_LYR-like DUF2431 PF10354.9 EDO16726.1 - 6.4e-54 182.7 0.2 3.2e-53 180.4 0.2 2.0 1 1 0 1 1 1 1 Domain of unknown function (DUF2431) Band_3_cyto PF07565.13 EDO16726.1 - 0.01 15.7 0.4 0.01 15.7 0.4 1.6 2 0 0 2 2 2 0 Band 3 cytoplasmic domain PIG-H PF10181.9 EDO16727.1 - 1.4e-19 69.7 0.7 2.5e-19 68.9 0.7 1.4 1 0 0 1 1 1 1 GPI-GlcNAc transferase complex, PIG-H component Myb_DNA-bind_7 PF15963.5 EDO16728.1 - 2.4e-27 94.7 0.1 2.4e-27 94.7 0.1 3.7 3 1 2 5 5 5 1 Myb DNA-binding like Myb_DNA-binding PF00249.31 EDO16728.1 - 1.5e-10 41.1 0.0 4.5e-10 39.5 0.0 1.8 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EDO16728.1 - 0.00055 20.1 1.1 0.0032 17.7 0.2 2.6 2 0 0 2 2 2 1 Myb-like DNA-binding domain WD40 PF00400.32 EDO16729.1 - 1.3e-07 32.1 1.9 0.016 16.0 0.2 3.8 4 0 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDO16729.1 - 0.00052 20.3 0.2 2.5 8.5 0.0 3.4 2 1 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Pkinase PF00069.25 EDO16730.1 - 2.6e-39 135.2 1.5 1.1e-38 133.1 0.0 2.2 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO16730.1 - 1.3e-27 96.7 1.1 1.9e-27 96.2 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase DUF2968 PF11180.8 EDO16730.1 - 0.55 9.8 18.6 1.2 8.7 18.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2968) MCU PF04678.13 EDO16730.1 - 1.2 9.2 3.7 3.5 7.7 3.7 1.7 1 0 0 1 1 1 0 Mitochondrial calcium uniporter DUF702 PF05142.12 EDO16730.1 - 4.3 7.8 7.9 0.61 10.5 3.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF702) DivIC PF04977.15 EDO16730.1 - 8.2 6.3 12.5 28 4.6 12.5 1.9 1 0 0 1 1 1 0 Septum formation initiator Arb2 PF09757.9 EDO16731.1 - 2.1e-77 259.7 0.3 2.4e-77 259.6 0.3 1.0 1 0 0 1 1 1 1 Arb2 domain V-set_CD47 PF08204.11 EDO16731.1 - 0.013 15.5 2.6 0.64 10.0 0.1 2.2 2 0 0 2 2 2 0 CD47 immunoglobulin-like domain Hist_deacetyl PF00850.19 EDO16732.1 - 5.1e-69 233.1 0.0 6.1e-69 232.8 0.0 1.1 1 0 0 1 1 1 1 Histone deacetylase domain Methyltr_RsmB-F PF01189.17 EDO16733.1 - 2.5e-21 76.3 0.0 2.3e-13 50.2 0.0 2.4 2 1 0 2 2 2 2 16S rRNA methyltransferase RsmB/F Methyltransf_15 PF09445.10 EDO16733.1 - 0.00088 18.9 0.3 0.018 14.6 0.1 2.3 2 0 0 2 2 2 1 RNA cap guanine-N2 methyltransferase zf-P11 PF03854.14 EDO16733.1 - 0.078 12.7 0.2 0.21 11.3 0.2 1.7 1 0 0 1 1 1 0 P-11 zinc finger Met_10 PF02475.16 EDO16733.1 - 0.085 12.6 0.0 0.16 11.7 0.0 1.6 1 0 0 1 1 1 0 Met-10+ like-protein Iso_dh PF00180.20 EDO16734.1 - 6.1e-107 357.8 0.0 7.4e-107 357.5 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase PMEI PF04043.15 EDO16734.1 - 0.12 12.7 0.1 0.22 11.8 0.1 1.4 1 0 0 1 1 1 0 Plant invertase/pectin methylesterase inhibitor MRP-S25 PF13741.6 EDO16735.1 - 3.4e-97 324.5 2.1 3.9e-97 324.3 2.1 1.0 1 0 0 1 1 1 1 Mitochondrial ribosomal protein S25 MRP-S23 PF10484.9 EDO16735.1 - 6.8e-06 26.4 1.1 0.0046 17.2 0.0 2.9 2 1 1 3 3 3 2 Mitochondrial ribosomal protein S23 DUF1242 PF06842.12 EDO16736.1 - 1.4e-15 56.8 0.1 1.8e-15 56.4 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1242) ICE2 PF08426.10 EDO16737.1 - 1.2e-152 508.8 27.8 1.4e-152 508.6 27.8 1.0 1 0 0 1 1 1 1 ICE2 Cyclin_N PF00134.23 EDO16738.1 - 4.3e-16 58.8 0.2 3.4e-15 55.9 0.1 2.2 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C_2 PF16899.5 EDO16738.1 - 0.0014 19.0 0.1 0.0026 18.1 0.1 1.5 1 0 0 1 1 1 1 Cyclin C-terminal domain Cyclin_C PF02984.19 EDO16738.1 - 0.054 13.6 3.3 0.56 10.3 0.0 3.1 3 0 0 3 3 3 0 Cyclin, C-terminal domain Aa_trans PF01490.18 EDO16739.1 - 1.4e-106 356.6 26.2 1.8e-106 356.3 26.2 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Y_phosphatase2 PF03162.13 EDO16740.1 - 6.1e-65 217.8 0.0 8.1e-65 217.4 0.0 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.6 EDO16740.1 - 9.2e-07 29.1 0.0 2.1e-06 27.9 0.0 1.4 1 1 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.20 EDO16740.1 - 0.0012 18.7 0.0 0.0023 17.7 0.0 1.6 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EDO16740.1 - 0.003 17.2 0.0 0.0049 16.5 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Histone PF00125.24 EDO16741.1 - 3.1e-49 166.7 3.4 3.4e-49 166.5 3.4 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.6 EDO16741.1 - 2e-06 28.1 0.0 3e-06 27.5 0.0 1.2 1 0 0 1 1 1 1 CENP-S protein PAF PF15715.5 EDO16741.1 - 5.5e-05 23.8 1.3 6.9e-05 23.5 1.3 1.2 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CENP-T_C PF15511.6 EDO16741.1 - 0.00011 22.3 0.8 0.00015 21.9 0.1 1.6 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold CBFD_NFYB_HMF PF00808.23 EDO16741.1 - 0.0018 18.5 0.9 0.0023 18.2 0.1 1.6 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 EDO16741.1 - 0.035 14.2 0.2 0.058 13.5 0.0 1.5 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit CENP-T_C PF15511.6 EDO16742.1 - 1.9e-09 37.6 0.1 2.2e-09 37.4 0.1 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold Histone PF00125.24 EDO16742.1 - 2.1e-05 24.9 0.1 2.5e-05 24.7 0.1 1.2 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TAF PF02969.17 EDO16742.1 - 3e-05 24.1 0.1 4.2e-05 23.6 0.1 1.3 1 0 0 1 1 1 1 TATA box binding protein associated factor (TAF) CBFD_NFYB_HMF PF00808.23 EDO16742.1 - 3.6e-05 24.0 0.1 6.1e-05 23.2 0.0 1.5 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-S PF15630.6 EDO16742.1 - 0.00017 21.9 0.1 0.00023 21.5 0.1 1.4 1 1 0 1 1 1 1 CENP-S protein TFIID-31kDa PF02291.15 EDO16742.1 - 0.0029 17.7 0.0 0.0035 17.4 0.0 1.1 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 EDO16742.1 - 0.0067 16.4 0.0 0.0096 15.9 0.0 1.2 1 0 0 1 1 1 1 Bromodomain associated TFIID_20kDa PF03847.13 EDO16742.1 - 0.043 14.3 0.0 0.072 13.6 0.0 1.4 1 0 0 1 1 1 0 Transcription initiation factor TFIID subunit A Met_10 PF02475.16 EDO16743.1 - 4.7e-12 46.1 0.1 1.8e-11 44.1 0.0 1.8 2 0 0 2 2 2 1 Met-10+ like-protein Cons_hypoth95 PF03602.15 EDO16743.1 - 1.6e-05 24.6 0.0 2.8e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 Conserved hypothetical protein 95 MTS PF05175.14 EDO16743.1 - 0.0012 18.5 0.0 0.0022 17.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain tRNA_U5-meth_tr PF05958.11 EDO16743.1 - 0.07 12.1 0.0 0.11 11.4 0.0 1.2 1 0 0 1 1 1 0 tRNA (Uracil-5-)-methyltransferase zf-H2C2_2 PF13465.6 EDO16744.1 - 4.8e-14 52.1 14.1 1.9e-07 31.2 1.8 3.7 3 1 0 3 3 3 3 Zinc-finger double domain zf-C2H2 PF00096.26 EDO16744.1 - 1.8e-12 47.0 13.8 8.7e-07 29.1 1.7 3.6 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EDO16744.1 - 4.8e-09 36.3 12.0 0.00081 20.0 1.1 3.6 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_6 PF13912.6 EDO16744.1 - 3.3e-07 30.2 8.9 0.0006 19.7 0.2 3.5 3 0 0 3 3 3 3 C2H2-type zinc finger zf-met PF12874.7 EDO16744.1 - 0.00015 22.0 3.4 0.0013 19.0 0.3 2.9 3 0 0 3 3 3 1 Zinc-finger of C2H2 type zf_UBZ PF18439.1 EDO16744.1 - 0.00056 19.4 2.1 0.015 14.9 0.4 2.7 3 0 0 3 3 3 1 Ubiquitin-Binding Zinc Finger Zn_ribbon_recom PF13408.6 EDO16744.1 - 0.0014 19.1 2.7 0.0014 19.1 2.7 2.2 2 0 0 2 2 2 1 Recombinase zinc beta ribbon domain TFIIA PF03153.13 EDO16744.1 - 0.0047 17.0 25.3 0.0066 16.5 11.9 2.3 2 0 0 2 2 2 2 Transcription factor IIA, alpha/beta subunit zf-C2H2_jaz PF12171.8 EDO16744.1 - 0.01 16.1 0.3 0.01 16.1 0.3 4.0 5 0 0 5 5 3 0 Zinc-finger double-stranded RNA-binding Zn_Tnp_IS1595 PF12760.7 EDO16744.1 - 0.36 10.8 3.3 0.84 9.7 3.3 1.6 1 0 0 1 1 1 0 Transposase zinc-ribbon domain zf-LYAR PF08790.11 EDO16744.1 - 0.68 9.9 5.9 0.68 9.9 0.7 3.2 3 0 0 3 3 3 0 LYAR-type C2HC zinc finger Zn-ribbon_8 PF09723.10 EDO16744.1 - 0.93 9.7 3.8 7.2 6.8 2.7 2.5 1 1 2 3 3 3 0 Zinc ribbon domain FYVE PF01363.21 EDO16744.1 - 1.2 9.4 5.4 3.2 7.9 5.4 1.7 1 0 0 1 1 1 0 FYVE zinc finger zf-AN1 PF01428.16 EDO16744.1 - 5.1 7.3 8.1 2.3 8.5 2.6 2.3 2 0 0 2 2 2 0 AN1-like Zinc finger C1_4 PF07975.12 EDO16744.1 - 9.9 6.5 10.0 0.46 10.7 2.8 2.6 2 1 1 3 3 2 0 TFIIH C1-like domain Bac_surface_Ag PF01103.23 EDO16745.1 - 1.2e-45 156.4 10.8 1.7e-45 156.0 10.8 1.2 1 0 0 1 1 1 1 Surface antigen ShlB PF03865.13 EDO16745.1 - 0.0086 15.6 0.8 0.21 11.0 0.0 2.5 2 0 0 2 2 2 1 Haemolysin secretion/activation protein ShlB/FhaC/HecB DUF3984 PF13136.6 EDO16745.1 - 0.22 10.9 0.0 0.4 10.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3984) DFP PF04127.15 EDO16746.1 - 1.5e-14 54.2 0.0 3.2e-06 27.1 0.0 3.0 2 1 0 2 2 2 2 DNA / pantothenate metabolism flavoprotein UCH PF00443.29 EDO16747.1 - 2e-46 158.6 0.6 3.4e-46 157.8 0.6 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EDO16747.1 - 0.00015 21.4 10.7 0.078 12.6 10.7 3.5 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UPF0565 PF10561.9 EDO16747.1 - 0.026 13.8 3.7 0.044 13.0 3.7 1.4 1 0 0 1 1 1 0 Uncharacterised protein family UPF0565 SRF-TF PF00319.18 EDO16747.1 - 0.17 11.4 5.4 0.85 9.2 2.3 2.5 2 0 0 2 2 2 0 SRF-type transcription factor (DNA-binding and dimerisation domain) OAD_gamma PF04277.13 EDO16748.1 - 0.094 13.3 1.2 0.16 12.6 1.2 1.5 1 1 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain BRE1 PF08647.11 EDO16748.1 - 0.25 11.4 9.5 0.62 10.2 1.2 2.2 2 0 0 2 2 2 0 BRE1 E3 ubiquitin ligase TFIIS_M PF07500.14 EDO16748.1 - 0.86 10.1 9.6 3.8 8.0 9.6 1.9 1 1 0 1 1 1 0 Transcription factor S-II (TFIIS), central domain ETRAMP PF09716.10 EDO16748.1 - 8.4 6.5 10.3 28 4.8 10.3 1.9 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) DS PF01916.17 EDO16753.1 - 0.033 13.5 0.0 0.045 13.0 0.0 1.1 1 0 0 1 1 1 0 Deoxyhypusine synthase DnaJ PF00226.31 EDO16754.1 - 1.4e-24 86.0 1.0 2.8e-24 85.0 1.0 1.5 1 0 0 1 1 1 1 DnaJ domain SPOB_a PF14689.6 EDO16754.1 - 0.027 14.2 0.0 0.053 13.2 0.0 1.4 1 0 0 1 1 1 0 Sensor_kinase_SpoOB-type, alpha-helical domain Nse4_C PF08743.10 EDO16755.1 - 2.8e-28 98.0 1.5 2.8e-28 98.0 1.5 2.3 3 0 0 3 3 3 1 Nse4 C-terminal Nse4-Nse3_bdg PF15412.6 EDO16755.1 - 1.1e-17 63.9 0.9 2.2e-17 62.9 0.9 1.6 1 0 0 1 1 1 1 Binding domain of Nse4/EID3 to Nse3-MAGE DUF1712 PF08217.11 EDO16756.1 - 2.2e-223 743.2 38.0 2.6e-223 743.0 38.0 1.0 1 0 0 1 1 1 1 Fungal domain of unknown function (DUF1712) AA_permease PF00324.21 EDO16757.1 - 5.5e-129 430.9 29.1 6.2e-129 430.7 29.1 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EDO16757.1 - 7.7e-24 84.3 32.9 1e-23 83.9 32.9 1.1 1 0 0 1 1 1 1 Amino acid permease PRMT5_TIM PF17285.2 EDO16758.1 - 2.5e-76 256.3 3.1 2.5e-76 256.3 3.1 1.9 2 0 0 2 2 2 1 PRMT5 TIM barrel domain PRMT5_C PF17286.2 EDO16758.1 - 2.1e-65 219.9 0.6 4.3e-65 218.9 0.6 1.5 1 0 0 1 1 1 1 PRMT5 oligomerisation domain PRMT5 PF05185.16 EDO16758.1 - 3.5e-59 199.5 0.0 6.3e-59 198.7 0.0 1.4 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase PI3_PI4_kinase PF00454.27 EDO16759.1 - 2e-52 178.5 0.6 7e-52 176.7 0.1 2.2 2 0 0 2 2 2 1 Phosphatidylinositol 3- and 4-kinase UME PF08064.13 EDO16759.1 - 3.7e-26 91.0 1.7 8.5e-25 86.6 0.7 3.7 2 0 0 2 2 2 1 UME (NUC010) domain FATC PF02260.20 EDO16759.1 - 7.3e-14 51.3 0.2 1.6e-13 50.2 0.2 1.6 1 0 0 1 1 1 1 FATC domain FAT PF02259.23 EDO16759.1 - 1.5e-06 27.6 2.7 6.2e-06 25.7 2.7 2.1 1 0 0 1 1 1 1 FAT domain Acp26Ab PF05777.12 EDO16759.1 - 0.12 13.0 0.3 1.1 10.0 0.0 2.8 2 0 0 2 2 2 0 Drosophila accessory gland-specific peptide 26Ab (Acp26Ab) TPR_14 PF13428.6 EDO16759.1 - 0.15 13.0 0.0 0.63 11.0 0.0 2.1 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_19 PF14559.6 EDO16759.1 - 0.16 12.5 0.1 0.54 10.8 0.1 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat Vac14_Fab1_bd PF12755.7 EDO16759.1 - 2.7 8.6 7.7 39 4.9 0.0 5.3 6 0 0 6 6 6 0 Vacuolar 14 Fab1-binding region TPR_11 PF13414.6 EDO16759.1 - 4.5 7.0 5.1 1.9 8.2 0.2 2.5 2 0 0 2 2 2 0 TPR repeat Pyridox_oxase_2 PF12766.7 EDO16761.1 - 2.7e-32 111.3 0.0 5.2e-32 110.4 0.0 1.5 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase fn3_2 PF16893.5 EDO16762.1 - 5.1e-38 129.1 0.6 9.9e-38 128.2 0.6 1.5 1 0 0 1 1 1 1 Fibronectin type III domain CHS5_N PF16892.5 EDO16762.1 - 2.9e-23 81.6 0.1 4.6e-23 80.9 0.1 1.3 1 0 0 1 1 1 1 Chitin biosynthesis protein CHS5 N-terminus BRCT PF00533.26 EDO16762.1 - 1.6e-08 34.8 0.0 5.8e-08 33.0 0.0 2.0 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain fn3 PF00041.21 EDO16762.1 - 0.0025 18.1 0.1 0.01 16.2 0.1 2.0 1 0 0 1 1 1 1 Fibronectin type III domain PTCB-BRCT PF12738.7 EDO16762.1 - 0.038 13.9 0.0 0.096 12.6 0.0 1.8 1 0 0 1 1 1 0 twin BRCT domain Transcrip_reg PF01709.20 EDO16763.1 - 8e-78 261.2 4.9 9.1e-78 261.0 4.9 1.0 1 0 0 1 1 1 1 Transcriptional regulator CENP-B_N PF04218.13 EDO16763.1 - 0.049 13.3 0.0 0.11 12.1 0.0 1.5 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain HTH_57 PF18679.1 EDO16763.1 - 0.1 12.9 3.2 6 7.2 0.2 3.1 3 0 0 3 3 3 0 ThcOx helix turn helix domain DUF3656 PF12392.8 EDO16763.1 - 0.1 13.2 3.4 0.11 13.1 0.5 2.3 3 0 0 3 3 3 0 Collagenase Mid2 PF04478.12 EDO16764.1 - 4.6e-49 166.1 0.8 1.9e-48 164.0 0.6 2.3 1 1 0 1 1 1 1 Mid2 like cell wall stress sensor ADH_N PF08240.12 EDO16765.1 - 6.2e-24 84.0 5.9 1.1e-23 83.1 5.9 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EDO16765.1 - 1.2e-15 57.7 0.0 1.9e-15 57.0 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 EDO16765.1 - 2.5e-06 27.0 0.1 4.7e-06 26.1 0.1 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.21 EDO16765.1 - 0.0004 19.7 0.0 0.00063 19.1 0.0 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain DUF364 PF04016.12 EDO16765.1 - 0.17 11.5 0.0 0.32 10.6 0.0 1.4 1 0 0 1 1 1 0 Putative heavy-metal chelation RseC_MucC PF04246.12 EDO16765.1 - 0.8 9.7 3.9 1.8 8.5 3.9 1.6 1 0 0 1 1 1 0 Positive regulator of sigma(E), RseC/MucC Thg1 PF04446.12 EDO16766.1 - 3.1e-50 169.4 1.4 4.6e-50 168.8 1.4 1.3 1 0 0 1 1 1 1 tRNAHis guanylyltransferase Thg1C PF14413.6 EDO16766.1 - 1.4e-37 128.6 1.4 2.1e-37 128.0 0.5 1.7 2 0 0 2 2 2 1 Thg1 C terminal domain Ribosomal_S25 PF03297.15 EDO16767.1 - 6.9e-39 132.1 8.6 7.7e-39 132.0 8.6 1.0 1 0 0 1 1 1 1 S25 ribosomal protein FtsK_gamma PF09397.10 EDO16767.1 - 0.00061 19.5 0.1 0.00092 19.0 0.1 1.3 1 0 0 1 1 1 1 Ftsk gamma domain HTH_CodY PF08222.11 EDO16767.1 - 0.025 14.1 0.3 0.037 13.6 0.3 1.3 1 0 0 1 1 1 0 CodY helix-turn-helix domain EAP30 PF04157.16 EDO16767.1 - 0.033 13.5 0.0 0.041 13.2 0.0 1.1 1 0 0 1 1 1 0 EAP30/Vps36 family HTH_DeoR PF08220.12 EDO16767.1 - 0.089 12.6 0.0 0.14 12.0 0.0 1.3 1 0 0 1 1 1 0 DeoR-like helix-turn-helix domain HTH_24 PF13412.6 EDO16767.1 - 0.12 12.0 0.1 0.17 11.5 0.1 1.3 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding DUF747 PF05346.11 EDO16768.1 - 7.9e-83 278.5 18.5 1.5e-82 277.7 18.5 1.4 1 0 0 1 1 1 1 Eukaryotic membrane protein family COX15-CtaA PF02628.15 EDO16769.1 - 1e-114 383.0 5.3 1.2e-114 382.7 5.3 1.0 1 0 0 1 1 1 1 Cytochrome oxidase assembly protein DUF3624 PF12292.8 EDO16769.1 - 0.11 12.9 0.9 0.6 10.6 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3624) Asp_protease PF09668.10 EDO16770.1 - 9.7e-51 170.7 0.1 1.6e-50 170.0 0.1 1.4 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 EDO16770.1 - 6.9e-20 71.4 0.1 1.7e-19 70.1 0.1 1.7 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 EDO16770.1 - 9e-10 39.1 0.1 2.5e-09 37.6 0.1 1.8 1 0 0 1 1 1 1 Aspartyl protease UBA PF00627.31 EDO16770.1 - 7.7e-08 32.1 0.0 2.2e-07 30.6 0.0 1.8 2 0 0 2 2 2 1 UBA/TS-N domain RVP PF00077.20 EDO16770.1 - 1e-05 25.8 0.1 4e-05 23.9 0.0 2.0 2 0 0 2 2 2 1 Retroviral aspartyl protease RVP_2 PF08284.11 EDO16770.1 - 0.01 15.6 0.0 0.022 14.5 0.0 1.5 1 0 0 1 1 1 0 Retroviral aspartyl protease UN_NPL4 PF11543.8 EDO16770.1 - 0.016 15.7 0.1 0.035 14.6 0.1 1.5 1 0 0 1 1 1 0 Nuclear pore localisation protein NPL4 Con-6 PF10346.9 EDO16770.1 - 0.8 9.8 2.5 1.9 8.6 2.5 1.6 1 0 0 1 1 1 0 Conidiation protein 6 Y_phosphatase2 PF03162.13 EDO16771.1 - 4.1e-46 156.6 1.2 5.2e-46 156.2 1.2 1.1 1 0 0 1 1 1 1 Tyrosine phosphatase family Phage_RpbA PF10789.9 EDO16772.1 - 0.074 13.1 0.3 0.089 12.9 0.3 1.1 1 0 0 1 1 1 0 Phage RNA polymerase binding, RpbA LSM PF01423.22 EDO16773.1 - 2.5e-20 71.9 0.2 2.8e-20 71.7 0.2 1.1 1 0 0 1 1 1 1 LSM domain BPL_C PF02237.17 EDO16773.1 - 0.0052 16.7 0.0 0.0073 16.2 0.0 1.4 1 0 0 1 1 1 1 Biotin protein ligase C terminal domain Ins_allergen_rp PF06757.13 EDO16773.1 - 0.16 11.9 0.0 0.22 11.4 0.0 1.3 1 0 0 1 1 1 0 Insect allergen related repeat, nitrile-specifier detoxification DUF768 PF05589.11 EDO16774.1 - 0.048 13.7 0.1 1 9.4 0.0 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF768) I_LWEQ PF01608.17 EDO16774.1 - 2.4 8.4 14.6 0.94 9.7 4.4 3.3 1 1 1 2 2 2 0 I/LWEQ domain Fasciclin PF02469.22 EDO16775.1 - 0.0019 18.4 0.0 0.0038 17.5 0.0 1.5 1 1 0 1 1 1 1 Fasciclin domain HLH PF00010.26 EDO16776.1 - 3.6e-17 62.0 1.3 7.3e-17 61.1 1.3 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Limkain-b1 PF11608.8 EDO16777.1 - 0.23 11.6 2.0 0.34 11.0 0.4 2.1 2 0 0 2 2 2 0 Limkain b1 XPG_N PF00752.17 EDO16778.1 - 1.3e-28 99.4 0.0 3.9e-28 97.9 0.0 1.8 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.18 EDO16778.1 - 1.4e-21 76.7 0.0 3.3e-21 75.4 0.0 1.7 1 0 0 1 1 1 1 XPG I-region 5_3_exonuc PF01367.20 EDO16778.1 - 0.00024 21.7 0.0 0.00085 19.9 0.0 1.9 1 0 0 1 1 1 1 5'-3' exonuclease, C-terminal SAM fold XPG_I_2 PF12813.7 EDO16778.1 - 0.0096 15.4 0.1 0.019 14.4 0.1 1.4 1 0 0 1 1 1 1 XPG domain containing HHH_2 PF12826.7 EDO16778.1 - 0.049 13.7 0.0 1.4 9.0 0.0 2.9 3 0 0 3 3 3 0 Helix-hairpin-helix motif Ank_2 PF12796.7 EDO16779.1 - 6e-29 100.5 0.6 8.3e-14 52.0 0.5 3.1 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) DHHC PF01529.20 EDO16779.1 - 6.6e-27 94.2 4.6 6.6e-27 94.2 4.6 2.7 2 1 0 2 2 2 1 DHHC palmitoyltransferase Ank_5 PF13857.6 EDO16779.1 - 4.5e-23 81.0 1.5 9.9e-09 35.3 0.1 4.6 2 2 2 4 4 4 4 Ankyrin repeats (many copies) Ank_4 PF13637.6 EDO16779.1 - 1.1e-21 76.8 0.9 3.7e-06 27.4 0.0 5.2 2 2 3 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EDO16779.1 - 2.9e-19 67.1 1.6 0.0027 18.1 0.0 6.5 6 0 0 6 6 6 4 Ankyrin repeat Ank PF00023.30 EDO16779.1 - 8.4e-19 67.1 2.9 3e-05 24.2 0.0 6.2 7 0 0 7 7 7 4 Ankyrin repeat TMCO5 PF14992.6 EDO16779.1 - 0.56 9.7 3.8 12 5.3 0.7 2.3 2 0 0 2 2 2 0 TMCO5 family UNC45-central PF11701.8 EDO16780.1 - 8e-29 100.6 2.0 8e-29 100.6 2.0 2.6 2 0 0 2 2 2 1 Myosin-binding striated muscle assembly central Pex2_Pex12 PF04757.14 EDO16781.1 - 7.6e-37 127.1 4.3 1.2e-36 126.4 4.3 1.3 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-RING_2 PF13639.6 EDO16781.1 - 4.1e-09 36.6 13.5 7.8e-09 35.7 13.5 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 EDO16781.1 - 8.1e-08 32.0 13.8 1.4e-07 31.3 13.8 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EDO16781.1 - 8.2e-08 32.0 12.0 1.6e-07 31.1 12.0 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EDO16781.1 - 1.1e-07 31.5 12.1 2.3e-07 30.6 12.1 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EDO16781.1 - 3.6e-06 26.9 5.5 3.6e-06 26.9 5.5 2.2 2 1 1 3 3 2 1 RING-type zinc-finger Prok-RING_4 PF14447.6 EDO16781.1 - 3.1e-05 23.7 14.9 5.5e-05 22.9 14.9 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 EDO16781.1 - 5.6e-05 23.0 8.1 0.00014 21.7 8.1 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-rbx1 PF12678.7 EDO16781.1 - 0.00019 21.6 12.6 0.00064 20.0 12.6 1.9 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_4 PF15227.6 EDO16781.1 - 0.0003 20.9 13.0 0.0003 20.9 13.0 1.7 2 0 0 2 2 1 1 zinc finger of C3HC4-type, RING Arb1 PF09692.10 EDO16781.1 - 0.098 11.8 0.0 3 6.9 0.0 2.1 2 0 0 2 2 2 0 Argonaute siRNA chaperone (ARC) complex subunit Arb1 DUF2705 PF10920.8 EDO16781.1 - 0.1 11.9 1.3 16 4.7 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF2705) zf-ANAPC11 PF12861.7 EDO16781.1 - 0.3 11.2 8.9 0.12 12.4 6.4 1.6 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_10 PF16685.5 EDO16781.1 - 3 8.0 12.3 2 8.6 10.1 1.9 2 0 0 2 2 1 0 zinc RING finger of MSL2 zf-RING_11 PF17123.5 EDO16781.1 - 4.1 7.2 11.3 0.11 12.3 4.5 2.0 2 0 0 2 2 2 0 RING-like zinc finger zf-C3HC4_3 PF13920.6 EDO16782.1 - 1.3e-07 31.4 8.1 1.3e-07 31.4 8.1 4.4 4 1 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) Strabismus PF06638.11 EDO16782.1 - 0.0036 16.0 0.1 0.0059 15.3 0.1 1.2 1 0 0 1 1 1 1 Strabismus protein zf-C3HC4_2 PF13923.6 EDO16782.1 - 0.0039 17.0 9.8 0.0039 17.0 9.8 3.5 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) Ima1_N PF09779.9 EDO16782.1 - 0.01 16.7 7.8 0.01 16.7 7.8 3.6 3 2 1 4 4 4 0 Ima1 N-terminal domain zf-C3HC4 PF00097.25 EDO16782.1 - 0.019 14.8 11.3 0.019 14.8 11.3 3.8 3 1 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) zf-Di19 PF05605.12 EDO16782.1 - 2.5 8.5 22.5 0.23 11.8 0.9 4.7 4 1 0 4 4 4 0 Drought induced 19 protein (Di19), zinc-binding zf-RING_2 PF13639.6 EDO16782.1 - 8.9 6.7 27.6 0.047 14.0 10.3 3.9 4 1 1 5 5 5 0 Ring finger domain Syntaxin_2 PF14523.6 EDO16783.1 - 1.9e-19 69.9 4.2 1.9e-19 69.9 4.2 2.5 2 1 0 2 2 2 1 Syntaxin-like protein SNARE PF05739.19 EDO16783.1 - 1.5e-12 47.3 0.4 1.5e-12 47.3 0.4 2.6 3 1 0 3 3 3 1 SNARE domain Use1 PF09753.9 EDO16783.1 - 2.5e-06 27.4 5.8 3.3e-06 27.0 5.8 1.1 1 0 0 1 1 1 1 Membrane fusion protein Use1 Syntaxin PF00804.25 EDO16783.1 - 0.00026 20.8 10.2 0.00056 19.6 10.2 1.6 1 1 0 1 1 1 1 Syntaxin FAM76 PF16046.5 EDO16783.1 - 0.25 10.7 7.5 0.036 13.4 2.9 1.7 1 1 1 2 2 2 0 FAM76 protein WD40 PF00400.32 EDO16784.1 - 2.9e-37 126.0 21.2 1e-07 32.5 0.0 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDO16784.1 - 7.1e-14 51.9 7.9 0.03 14.6 0.0 5.4 3 3 2 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Coatomer_WDAD PF04053.14 EDO16784.1 - 0.018 14.1 7.8 0.21 10.6 1.2 2.5 2 1 1 3 3 3 0 Coatomer WD associated region BING4CT PF08149.11 EDO16784.1 - 0.045 13.6 0.0 12 5.8 0.0 2.3 2 0 0 2 2 2 0 BING4CT (NUC141) domain IKI3 PF04762.12 EDO16784.1 - 0.45 8.5 4.7 3.1 5.7 1.7 2.4 2 1 0 2 2 2 0 IKI3 family FAD_binding_6 PF00970.24 EDO16785.1 - 1.5e-05 25.2 0.0 8.8e-05 22.8 0.0 2.3 1 1 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.21 EDO16785.1 - 0.023 15.3 0.0 0.06 14.0 0.0 1.8 1 1 0 1 1 1 0 Oxidoreductase NAD-binding domain tRNA-synt_1b PF00579.25 EDO16786.1 - 7.8e-75 251.9 0.0 1e-74 251.5 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) Hira PF07569.11 EDO16787.1 - 1.1e-87 293.4 7.3 1.6e-86 289.6 0.0 3.5 5 0 0 5 5 5 2 TUP1-like enhancer of split Cnl2_NKP2 PF09447.10 EDO16787.1 - 0.061 13.5 0.1 2.1 8.6 0.0 2.6 2 0 0 2 2 2 0 Cnl2/NKP2 family protein WD40 PF00400.32 EDO16787.1 - 0.15 13.0 0.6 28 5.8 0.0 3.9 4 0 0 4 4 4 0 WD domain, G-beta repeat CK_II_beta PF01214.18 EDO16788.1 - 4.4e-72 241.7 0.1 5.2e-72 241.5 0.1 1.0 1 0 0 1 1 1 1 Casein kinase II regulatory subunit DUF713 PF05218.14 EDO16788.1 - 0.0082 15.9 0.2 0.013 15.3 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF713) CxC5 PF18718.1 EDO16788.1 - 0.12 12.5 0.0 0.22 11.6 0.0 1.4 1 0 0 1 1 1 0 CxC5 like cysteine cluster associated with KDZ transposases E1-E2_ATPase PF00122.20 EDO16789.1 - 2.7e-47 160.6 0.1 2.7e-47 160.6 0.1 2.4 4 0 0 4 4 4 1 E1-E2 ATPase Hydrolase PF00702.26 EDO16789.1 - 1.9e-32 113.3 0.0 3.3e-32 112.5 0.0 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HMA PF00403.26 EDO16789.1 - 8.3e-25 87.0 10.7 1.2e-13 51.2 1.6 3.7 3 0 0 3 3 3 2 Heavy-metal-associated domain Hydrolase_3 PF08282.12 EDO16789.1 - 1.6e-06 28.0 1.2 6.6e-05 22.8 0.1 3.0 3 0 0 3 3 3 1 haloacid dehalogenase-like hydrolase Poly_export PF02563.16 EDO16789.1 - 0.094 12.9 0.2 2.1 8.6 0.0 2.8 3 0 0 3 3 3 0 Polysaccharide biosynthesis/export protein Spore_YhcN_YlaJ PF09580.10 EDO16789.1 - 0.13 12.4 4.2 2.8 8.0 0.3 2.7 2 0 0 2 2 2 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) HTH_10 PF04967.12 EDO16789.1 - 0.14 12.0 0.0 0.51 10.2 0.0 2.0 1 0 0 1 1 1 0 HTH DNA binding domain HAGH_C PF16123.5 EDO16790.1 - 7.3e-15 55.3 0.2 1.7e-14 54.1 0.1 1.7 2 0 0 2 2 2 1 Hydroxyacylglutathione hydrolase C-terminus Lactamase_B PF00753.27 EDO16790.1 - 5.1e-11 42.9 0.0 1e-10 42.0 0.0 1.5 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EDO16790.1 - 3.2e-05 23.6 0.2 6.3e-05 22.6 0.2 1.6 1 1 0 1 1 1 1 Beta-lactamase superfamily domain CUE PF02845.16 EDO16791.1 - 1.6e-11 43.7 0.0 3.7e-11 42.5 0.0 1.7 1 0 0 1 1 1 1 CUE domain BTB_2 PF02214.22 EDO16792.1 - 0.0057 17.0 0.1 0.018 15.4 0.0 1.8 2 0 0 2 2 2 1 BTB/POZ domain Tom6 PF17112.5 EDO16793.1 - 2.7e-27 94.0 0.3 3.6e-27 93.6 0.3 1.2 1 0 0 1 1 1 1 Mitochondrial import receptor subunit Tom6, fungal Pmp3 PF01679.17 EDO16794.1 - 6.2e-14 51.9 8.5 7.3e-14 51.7 8.5 1.1 1 0 0 1 1 1 1 Proteolipid membrane potential modulator DUF3533 PF12051.8 EDO16795.1 - 5.6e-139 463.3 17.3 6.6e-139 463.0 17.3 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3533) PDR_CDR PF06422.12 EDO16795.1 - 0.088 12.7 0.1 0.088 12.7 0.1 2.7 3 0 0 3 3 3 0 CDR ABC transporter DUF3533 PF12051.8 EDO16796.1 - 4.2e-138 460.4 20.5 5.8e-138 459.9 20.5 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3533) STD1 PF17235.2 EDO16797.1 - 5.8e-69 231.8 5.7 5.8e-69 231.8 5.7 2.0 2 1 0 2 2 2 1 STD1/MTH1 PI3K_1B_p101 PF10486.9 EDO16797.1 - 0.086 10.6 6.8 0.0058 14.5 1.2 1.7 2 0 0 2 2 2 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit RTA1 PF04479.13 EDO16798.1 - 2e-69 233.3 10.3 2.8e-69 232.9 10.3 1.2 1 0 0 1 1 1 1 RTA1 like protein TP_methylase PF00590.20 EDO16799.1 - 5.3e-39 134.4 0.0 6.9e-39 134.0 0.0 1.1 1 0 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases Sirohm_synth_M PF14824.6 EDO16799.1 - 1.2e-08 34.2 0.0 2.7e-08 33.1 0.0 1.6 1 0 0 1 1 1 1 Sirohaem biosynthesis protein central Sirohm_synth_C PF14823.6 EDO16799.1 - 0.011 15.4 0.1 2.2 7.9 0.0 2.5 2 0 0 2 2 2 0 Sirohaem biosynthesis protein C-terminal NAD_binding_7 PF13241.6 EDO16799.1 - 0.022 15.2 0.0 0.043 14.2 0.0 1.5 1 0 0 1 1 1 0 Putative NAD(P)-binding Cytochrome-c551 PF10643.9 EDO16799.1 - 0.043 13.4 0.0 0.07 12.7 0.0 1.3 1 0 0 1 1 1 0 Photosystem P840 reaction-centre cytochrome c-551 Ribosomal_S4e PF00900.20 EDO16800.1 - 7e-40 134.8 1.7 1.8e-38 130.3 0.8 2.2 2 0 0 2 2 2 1 Ribosomal family S4e 40S_S4_C PF16121.5 EDO16800.1 - 2.2e-26 91.2 0.1 4.6e-26 90.2 0.1 1.6 1 0 0 1 1 1 1 40S ribosomal protein S4 C-terminus KOW PF00467.29 EDO16800.1 - 2.7e-06 27.1 1.8 2.7e-06 27.1 1.8 3.4 5 0 0 5 5 5 1 KOW motif S4 PF01479.25 EDO16800.1 - 5.6e-05 22.8 0.0 0.00015 21.4 0.0 1.8 1 0 0 1 1 1 1 S4 domain Sipho_tail PF05709.11 EDO16800.1 - 0.023 14.1 0.1 0.043 13.2 0.1 1.6 1 1 0 1 1 1 0 Phage tail protein dCache_2 PF08269.11 EDO16800.1 - 0.1 11.8 0.0 0.2 10.8 0.0 1.6 1 1 0 1 1 1 0 Cache domain MnmE_helical PF12631.7 EDO16801.1 - 4.3e-41 141.4 3.0 5.9e-41 140.9 3.0 1.2 1 0 0 1 1 1 1 MnmE helical domain TrmE_N PF10396.9 EDO16801.1 - 6.8e-36 123.1 0.0 1.6e-35 121.9 0.0 1.7 1 0 0 1 1 1 1 GTP-binding protein TrmE N-terminus MMR_HSR1 PF01926.23 EDO16801.1 - 1.2e-20 73.7 0.5 3.8e-20 72.1 0.5 1.9 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EDO16801.1 - 7.7e-11 41.8 1.9 1.5e-10 40.8 1.9 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 EDO16801.1 - 1.8e-07 31.3 1.9 0.0035 17.3 0.4 2.4 2 0 0 2 2 2 2 RsgA GTPase Ras PF00071.22 EDO16801.1 - 0.0014 18.3 0.4 0.0094 15.6 0.1 2.5 2 1 0 2 2 2 1 Ras family Dynamin_N PF00350.23 EDO16801.1 - 0.003 17.7 4.9 0.011 15.7 0.1 3.2 3 0 0 3 3 3 1 Dynamin family Arf PF00025.21 EDO16801.1 - 0.003 17.0 2.0 0.052 13.0 2.0 2.3 1 1 0 1 1 1 1 ADP-ribosylation factor family BLI1 PF17324.2 EDO16802.1 - 2.9e-50 169.6 6.4 3.3e-50 169.4 6.4 1.0 1 0 0 1 1 1 1 BLOC-1 interactor 1 DUF2347 PF09804.9 EDO16803.1 - 7.3e-90 301.4 0.5 1e-89 300.9 0.5 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2347) Avl9 PF09794.9 EDO16803.1 - 3e-09 36.1 0.6 3.8e-07 29.2 0.0 2.8 2 1 0 3 3 3 2 Transport protein Avl9 DUF4484 PF14831.6 EDO16803.1 - 1.2e-08 35.3 0.7 2.1e-05 24.7 0.0 2.5 1 1 1 2 2 2 2 Domain of unknown function (DUF4484) SPA PF08616.10 EDO16803.1 - 0.0011 18.9 0.1 0.003 17.5 0.1 1.7 1 0 0 1 1 1 1 Stabilization of polarity axis Afi1 PF07792.12 EDO16803.1 - 0.13 12.7 1.2 0.63 10.5 0.1 2.5 2 1 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Glyco_hydro_76 PF03663.14 EDO16804.1 - 9e-158 525.6 26.2 1e-157 525.4 26.2 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 Glyco_hydro_88 PF07470.13 EDO16804.1 - 0.01 14.9 1.0 0.01 14.9 1.0 2.9 2 1 1 3 3 3 0 Glycosyl Hydrolase Family 88 UQ_con PF00179.26 EDO16805.1 - 2.4e-48 163.3 0.0 2.7e-48 163.2 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Copper-fist PF00649.18 EDO16806.1 - 2.7e-19 68.4 2.3 6.3e-19 67.2 2.3 1.7 1 0 0 1 1 1 1 Copper fist DNA binding domain Polo_box_3 PF18544.1 EDO16806.1 - 0.14 12.8 0.3 1.4 9.6 0.4 2.4 2 0 0 2 2 2 0 Polo box domain DNA_primase_lrg PF04104.14 EDO16807.1 - 1.2e-88 297.0 1.4 1.8e-88 296.4 1.4 1.3 1 0 0 1 1 1 1 Eukaryotic and archaeal DNA primase, large subunit Hid1 PF12722.7 EDO16808.1 - 2.4 6.2 20.0 1.3 7.0 13.6 2.0 2 0 0 2 2 2 0 High-temperature-induced dauer-formation protein Macoilin PF09726.9 EDO16808.1 - 2.7 6.5 35.7 2.3 6.7 31.1 2.1 2 0 0 2 2 2 0 Macoilin family Neur_chan_memb PF02932.16 EDO16808.1 - 6.9 6.7 15.0 13 5.8 8.2 2.4 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region p450 PF00067.22 EDO16809.1 - 2.1e-53 181.7 0.0 2.7e-53 181.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 AbiGi PF10899.8 EDO16809.1 - 0.022 14.6 0.1 0.04 13.8 0.1 1.3 1 0 0 1 1 1 0 Putative abortive phage resistance protein AbiGi, antitoxin Snf7 PF03357.21 EDO16811.1 - 5.1e-33 114.1 18.9 5.1e-33 114.1 18.9 1.5 1 1 0 1 1 1 1 Snf7 PAS_7 PF12860.7 EDO16811.1 - 0.001 19.2 2.8 0.16 12.1 0.2 2.9 1 1 2 3 3 3 2 PAS fold AAA_15 PF13175.6 EDO16811.1 - 0.029 14.1 8.8 0.05 13.3 8.8 1.3 1 1 0 1 1 1 0 AAA ATPase domain DUF4208 PF13907.6 EDO16811.1 - 0.12 12.8 6.6 0.34 11.4 0.5 3.5 1 1 2 4 4 4 0 Domain of unknown function (DUF4208) Eno-Rase_FAD_bd PF07055.12 EDO16811.1 - 0.16 12.4 3.1 0.34 11.4 2.2 2.1 1 1 1 2 2 2 0 Enoyl reductase FAD binding domain Mod_r PF07200.13 EDO16811.1 - 2.3 8.3 12.6 3.6 7.7 12.1 1.7 1 1 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein YtxH PF12732.7 EDO16811.1 - 2.6 8.6 7.2 0.95 10.0 0.6 2.9 3 0 0 3 3 3 0 YtxH-like protein Prominin PF05478.11 EDO16811.1 - 6.1 4.7 12.6 2.9 5.7 3.0 1.8 1 1 1 2 2 2 0 Prominin PhoU PF01895.19 EDO16811.1 - 7.2 7.1 10.9 0.17 12.4 1.1 2.8 3 1 0 3 3 3 0 PhoU domain Adap_comp_sub PF00928.21 EDO16812.1 - 9.2e-68 228.5 6.9 1.4e-67 227.9 6.9 1.3 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Pterin_4a PF01329.19 EDO16813.1 - 4.9e-23 81.1 0.0 5.9e-23 80.9 0.0 1.1 1 0 0 1 1 1 1 Pterin 4 alpha carbinolamine dehydratase Toxin_trans PF07952.12 EDO16813.1 - 0.095 11.8 0.0 0.1 11.6 0.0 1.1 1 0 0 1 1 1 0 Clostridium neurotoxin, Translocation domain Lung_7-TM_R PF06814.13 EDO16814.1 - 1.5e-82 277.2 25.6 1.9e-82 276.9 25.6 1.1 1 0 0 1 1 1 1 Lung seven transmembrane receptor TMCCDC2 PF15844.5 EDO16814.1 - 5 7.0 7.0 6 6.8 1.8 2.5 2 1 0 2 2 2 0 Transmembrane and coiled-coil domain-containing protein 2 Actin PF00022.19 EDO16815.1 - 1.9e-90 303.4 0.0 4.7e-53 180.3 0.0 2.0 1 1 1 2 2 2 2 Actin MreB_Mbl PF06723.13 EDO16815.1 - 4.7e-05 22.4 0.0 0.055 12.3 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein FtsA PF14450.6 EDO16815.1 - 0.0021 18.5 0.0 0.0055 17.1 0.0 1.7 1 1 0 1 1 1 1 Cell division protein FtsA TFIIS_C PF01096.18 EDO16816.1 - 1.2e-16 60.2 1.6 1.2e-16 60.2 1.6 2.7 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) RNA_POL_M_15KD PF02150.16 EDO16816.1 - 1.6e-13 50.2 7.9 9.9e-11 41.3 0.5 3.0 2 1 0 2 2 2 2 RNA polymerases M/15 Kd subunit DZR PF12773.7 EDO16816.1 - 8.6e-05 22.5 7.3 0.054 13.5 0.2 2.7 2 1 0 2 2 2 2 Double zinc ribbon zf-H2C2_2 PF13465.6 EDO16816.1 - 0.00073 19.9 4.4 0.037 14.5 0.1 3.4 3 0 0 3 3 3 1 Zinc-finger double domain zf-TFIIB PF13453.6 EDO16816.1 - 0.0019 17.5 3.5 0.0076 15.6 0.9 2.4 2 0 0 2 2 2 1 Transcription factor zinc-finger zinc_ribbon_4 PF13717.6 EDO16816.1 - 0.0065 16.4 9.1 4.7 7.2 0.1 3.5 3 0 0 3 3 3 2 zinc-ribbon domain Zn_Tnp_IS1595 PF12760.7 EDO16816.1 - 0.0071 16.3 5.7 0.38 10.8 3.2 2.8 2 1 0 2 2 2 1 Transposase zinc-ribbon domain DpnI PF06044.12 EDO16816.1 - 0.0092 15.6 2.7 1.1 8.9 0.1 2.1 2 0 0 2 2 2 2 Dam-replacing family zf-CSL PF05207.13 EDO16816.1 - 0.012 15.3 0.2 0.012 15.3 0.2 2.1 2 1 0 2 2 1 0 CSL zinc finger C1_1 PF00130.22 EDO16816.1 - 0.023 14.6 1.7 0.96 9.4 0.1 2.4 2 1 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) TackOD1 PF18551.1 EDO16816.1 - 0.05 13.3 6.8 0.32 10.7 0.2 2.8 1 1 2 3 3 3 0 Thaumarchaeal output domain 1 DUF2072 PF09845.9 EDO16816.1 - 0.085 13.1 0.1 0.085 13.1 0.1 2.2 1 1 2 3 3 3 0 Zn-ribbon containing protein Zn_Tnp_IS1 PF03811.13 EDO16816.1 - 0.1 12.4 1.7 27 4.6 0.0 3.2 3 0 0 3 3 3 0 InsA N-terminal domain PADR1 PF08063.12 EDO16816.1 - 0.12 12.2 6.0 1.5 8.7 0.1 3.6 4 0 0 4 4 4 0 PADR1 (NUC008) domain HypA PF01155.19 EDO16816.1 - 0.14 12.1 7.3 7.1 6.7 0.3 2.7 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zinc-ribbons_6 PF07191.12 EDO16816.1 - 0.15 12.0 9.8 1.1 9.3 1.2 3.0 3 0 0 3 3 3 0 zinc-ribbons Stc1 PF12898.7 EDO16816.1 - 0.17 12.5 8.0 0.23 12.0 0.8 2.4 1 1 1 2 2 2 0 Stc1 domain CpXC PF14353.6 EDO16816.1 - 0.2 11.7 0.1 0.2 11.7 0.1 3.0 1 1 2 3 3 3 0 CpXC protein TF_Zn_Ribbon PF08271.12 EDO16816.1 - 0.3 10.6 11.8 0.7 9.4 3.3 3.1 2 2 0 2 2 2 0 TFIIB zinc-binding Zn_Tnp_IS91 PF14319.6 EDO16816.1 - 0.58 10.2 6.1 5.5 7.1 1.6 2.7 1 1 1 2 2 2 0 Transposase zinc-binding domain zf-RanBP PF00641.18 EDO16816.1 - 0.64 9.4 8.6 3.6 7.0 0.0 3.5 3 0 0 3 3 3 0 Zn-finger in Ran binding protein and others zf-C2HE PF16278.5 EDO16816.1 - 0.86 10.1 0.0 0.86 10.1 0.0 2.7 3 1 0 3 3 2 0 C2HE / C2H2 / C2HC zinc-binding finger Baculo_LEF5_C PF11792.8 EDO16816.1 - 0.89 9.3 3.9 1.5 8.5 0.0 2.7 3 0 0 3 3 2 0 Baculoviridae late expression factor 5 C-terminal domain zinc_ribbon_2 PF13240.6 EDO16816.1 - 1.1 9.0 14.6 1.3 8.8 2.1 4.1 3 2 1 4 4 4 0 zinc-ribbon domain Ribosomal_S27e PF01667.17 EDO16816.1 - 1.1 9.0 6.9 6 6.7 0.1 3.4 3 1 1 4 4 4 0 Ribosomal protein S27 Ogr_Delta PF04606.12 EDO16816.1 - 1.3 9.0 7.4 3.1 7.9 4.3 2.5 2 1 0 2 2 2 0 Ogr/Delta-like zinc finger OrfB_Zn_ribbon PF07282.11 EDO16816.1 - 1.4 8.9 6.8 15 5.6 0.2 2.7 2 1 0 2 2 2 0 Putative transposase DNA-binding domain Nudix_N_2 PF14803.6 EDO16816.1 - 1.6 8.7 8.3 5.2 7.1 1.0 3.7 3 1 0 3 3 3 0 Nudix N-terminal Nop10p PF04135.12 EDO16816.1 - 2.1 8.4 5.8 0.52 10.4 0.8 2.5 2 1 1 3 3 2 0 Nucleolar RNA-binding protein, Nop10p family Zn-ribbon_8 PF09723.10 EDO16816.1 - 2.7 8.2 13.3 5.3 7.2 0.7 3.4 2 2 1 3 3 3 0 Zinc ribbon domain zinc_ribbon_9 PF14369.6 EDO16816.1 - 3.3 8.0 7.4 35 4.8 0.0 3.6 3 1 0 3 3 3 0 zinc-ribbon zf-ribbon_3 PF13248.6 EDO16816.1 - 3.7 7.1 12.4 1.8 8.1 0.6 4.0 4 0 0 4 4 4 0 zinc-ribbon domain A2L_zn_ribbon PF08792.10 EDO16816.1 - 6.6 6.6 13.1 18 5.2 0.2 4.0 4 0 0 4 4 4 0 A2L zinc ribbon domain zf_UBZ PF18439.1 EDO16816.1 - 6.7 6.4 12.3 15 5.3 0.2 4.1 4 0 0 4 4 4 0 Ubiquitin-Binding Zinc Finger zf-C2H2_4 PF13894.6 EDO16816.1 - 8.5 7.5 12.7 30 5.8 0.2 3.8 4 0 0 4 4 3 0 C2H2-type zinc finger VP_N-CPKC PF11475.8 EDO16816.1 - 9.6 6.2 8.3 7 6.7 0.2 3.1 3 0 0 3 3 3 0 Virion protein N terminal domain CN_hydrolase PF00795.22 EDO16817.1 - 5.6e-18 65.2 0.0 1.1e-16 61.0 0.0 2.1 2 0 0 2 2 2 2 Carbon-nitrogen hydrolase LicD PF04991.13 EDO16818.1 - 5.6e-56 190.2 2.2 5.6e-56 190.2 2.2 4.9 3 1 1 4 4 4 1 LicD family Asp-B-Hydro_N PF05279.11 EDO16818.1 - 0.23 11.5 52.2 0.47 10.5 52.2 1.5 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Pkinase PF00069.25 EDO16819.1 - 2.2e-37 128.9 0.0 4.3e-37 127.9 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO16819.1 - 7.2e-16 58.2 0.0 1.2e-15 57.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDO16819.1 - 1.7e-05 24.3 0.0 5.9e-05 22.5 0.0 1.8 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 EDO16819.1 - 0.0012 18.2 0.0 0.0022 17.4 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 EDO16819.1 - 0.0017 18.0 0.1 0.3 10.7 0.0 2.5 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 YrbL-PhoP_reg PF10707.9 EDO16819.1 - 0.011 15.3 0.1 0.058 12.9 0.1 2.0 1 1 0 1 1 1 0 PhoP regulatory network protein YrbL Pkinase_fungal PF17667.1 EDO16819.1 - 0.03 13.1 0.0 0.03 13.1 0.0 2.3 3 0 0 3 3 3 0 Fungal protein kinase APH PF01636.23 EDO16819.1 - 0.12 12.3 0.1 0.2 11.5 0.1 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family AAA PF00004.29 EDO16820.1 - 8.3e-52 175.1 0.1 2.1e-42 144.6 0.0 3.3 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) PEX-1N PF09262.11 EDO16820.1 - 7.3e-23 80.8 1.5 1.5e-22 79.8 0.0 2.4 3 0 0 3 3 1 1 Peroxisome biogenesis factor 1, N-terminal AAA_16 PF13191.6 EDO16820.1 - 3.3e-12 47.1 0.0 2.2e-05 24.9 0.0 3.5 2 1 1 3 3 3 2 AAA ATPase domain AAA_14 PF13173.6 EDO16820.1 - 4.1e-08 33.3 0.5 0.00059 19.9 0.0 3.6 3 0 0 3 3 3 2 AAA domain AAA_lid_3 PF17862.1 EDO16820.1 - 5.4e-08 32.5 0.1 3.2e-06 26.8 0.0 3.1 3 0 0 3 3 3 1 AAA+ lid domain AAA_22 PF13401.6 EDO16820.1 - 1.3e-06 28.7 2.1 0.0084 16.4 0.0 3.8 3 2 1 4 4 4 2 AAA domain NACHT PF05729.12 EDO16820.1 - 3.2e-06 27.2 0.2 0.02 14.8 0.0 3.1 3 0 0 3 3 3 2 NACHT domain AAA_18 PF13238.6 EDO16820.1 - 5.5e-06 27.0 1.5 0.14 12.7 0.0 3.5 4 0 0 4 4 2 2 AAA domain AAA_33 PF13671.6 EDO16820.1 - 1.7e-05 25.0 0.0 0.14 12.3 0.0 3.1 3 0 0 3 3 2 2 AAA domain TsaE PF02367.17 EDO16820.1 - 5.3e-05 23.2 0.0 0.063 13.3 0.0 2.7 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE IstB_IS21 PF01695.17 EDO16820.1 - 0.00021 21.1 0.0 1.5 8.6 0.0 3.4 3 0 0 3 3 3 1 IstB-like ATP binding protein AAA_24 PF13479.6 EDO16820.1 - 0.00036 20.3 0.0 0.13 12.0 0.0 2.8 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 EDO16820.1 - 0.00043 20.7 0.0 1.7 9.1 0.0 3.0 2 0 0 2 2 2 2 RNA helicase AAA_5 PF07728.14 EDO16820.1 - 0.00048 20.1 0.0 0.93 9.5 0.0 3.0 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 EDO16820.1 - 0.00066 19.8 0.0 0.018 15.2 0.0 2.8 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) Viral_helicase1 PF01443.18 EDO16820.1 - 0.001 18.9 0.0 0.55 9.9 0.0 2.7 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase Sigma54_activat PF00158.26 EDO16820.1 - 0.0013 18.4 0.0 1.4 8.6 0.0 3.0 2 0 0 2 2 2 1 Sigma-54 interaction domain NB-ARC PF00931.22 EDO16820.1 - 0.0016 17.7 0.0 1.7 7.8 0.0 2.8 2 0 0 2 2 2 2 NB-ARC domain Bac_DnaA PF00308.18 EDO16820.1 - 0.0026 17.6 0.0 2.2 8.1 0.0 3.5 3 0 0 3 3 3 1 Bacterial dnaA protein RuvB_N PF05496.12 EDO16820.1 - 0.0031 17.3 0.0 0.11 12.2 0.0 2.7 3 0 0 3 3 2 1 Holliday junction DNA helicase RuvB P-loop domain RsgA_GTPase PF03193.16 EDO16820.1 - 0.0038 17.2 0.3 0.03 14.2 0.1 2.6 2 0 0 2 2 2 1 RsgA GTPase TIP49 PF06068.13 EDO16820.1 - 0.0043 16.3 1.0 0.23 10.6 0.0 3.1 2 1 1 3 3 3 1 TIP49 P-loop domain AAA_17 PF13207.6 EDO16820.1 - 0.0074 16.7 0.1 7.5 7.0 0.0 3.1 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 EDO16820.1 - 0.0088 16.3 0.0 4.5 7.5 0.0 2.4 2 0 0 2 2 2 1 AAA domain DUF2075 PF09848.9 EDO16820.1 - 0.012 14.9 1.7 5 6.3 0.0 3.6 4 0 0 4 4 3 0 Uncharacterized conserved protein (DUF2075) NTPase_1 PF03266.15 EDO16820.1 - 0.024 14.6 0.0 0.34 10.8 0.0 2.4 2 0 0 2 2 2 0 NTPase Cytidylate_kin2 PF13189.6 EDO16820.1 - 0.028 14.5 0.2 0.094 12.8 0.0 2.0 2 0 0 2 2 1 0 Cytidylate kinase-like family Vps4_C PF09336.10 EDO16820.1 - 0.035 14.1 0.2 0.17 11.9 0.1 2.2 2 0 0 2 2 1 0 Vps4 C terminal oligomerisation domain AAA_30 PF13604.6 EDO16820.1 - 0.042 13.6 0.0 1.7 8.4 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_3 PF07726.11 EDO16820.1 - 0.062 13.2 0.0 11 5.9 0.0 2.6 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.12 EDO16820.1 - 0.075 12.3 0.0 11 5.2 0.0 2.5 2 0 0 2 2 2 0 Zeta toxin AAA_25 PF13481.6 EDO16820.1 - 0.076 12.6 0.0 2.5 7.6 0.0 2.7 3 0 0 3 3 3 0 AAA domain PRK PF00485.18 EDO16820.1 - 0.079 12.7 2.7 2.9 7.6 0.0 3.3 5 0 0 5 5 3 0 Phosphoribulokinase / Uridine kinase family Mg_chelatase PF01078.21 EDO16820.1 - 0.1 11.9 0.0 3.8 6.8 0.0 2.4 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI SRP54 PF00448.22 EDO16820.1 - 0.12 12.0 0.0 1.8 8.1 0.0 2.4 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_19 PF13245.6 EDO16820.1 - 0.14 12.5 0.0 1.5 9.1 0.0 2.4 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.27 EDO16820.1 - 0.4 11.2 0.1 0.4 11.2 0.1 4.7 5 2 0 5 5 3 0 ABC transporter Rieske PF00355.26 EDO16821.1 - 1.3e-11 44.3 0.0 2.2e-11 43.5 0.0 1.4 1 1 0 1 1 1 1 Rieske [2Fe-2S] domain UCR_TM PF02921.14 EDO16821.1 - 3.4e-07 30.6 1.2 3.4e-07 30.6 1.2 1.6 2 0 0 2 2 2 1 Ubiquinol cytochrome reductase transmembrane region Sec7 PF01369.20 EDO16822.1 - 1.2e-67 227.2 0.6 2.8e-67 226.0 0.6 1.7 1 0 0 1 1 1 1 Sec7 domain Sec7_N PF12783.7 EDO16822.1 - 1.9e-15 57.1 0.5 1.9e-15 57.1 0.5 4.4 4 1 0 4 4 4 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DCB PF16213.5 EDO16822.1 - 3.6e-05 23.5 3.1 3.6e-05 23.5 3.1 3.1 3 0 0 3 3 3 1 Dimerisation and cyclophilin-binding domain of Mon2 HC2 PF07382.11 EDO16822.1 - 1.6 8.8 7.3 2.5 8.1 7.3 1.2 1 0 0 1 1 1 0 Histone H1-like nucleoprotein HC2 OMPdecase PF00215.24 EDO16823.1 - 1.5e-77 260.2 0.0 1.7e-77 260.0 0.0 1.0 1 0 0 1 1 1 1 Orotidine 5'-phosphate decarboxylase / HUMPS family zf-Tim10_DDP PF02953.15 EDO16824.1 - 5.6e-21 74.0 7.7 7.5e-21 73.6 7.7 1.3 1 0 0 1 1 1 1 Tim10/DDP family zinc finger Phasin_2 PF09361.10 EDO16824.1 - 0.016 15.4 0.1 0.14 12.4 0.0 2.0 1 1 1 2 2 2 0 Phasin protein DUF1178 PF06676.11 EDO16824.1 - 0.019 15.4 0.4 0.025 15.0 0.4 1.2 1 1 0 1 1 1 0 Protein of unknown function (DUF1178) Tam41_Mmp37 PF09139.11 EDO16824.1 - 0.035 13.6 0.6 0.037 13.5 0.6 1.0 1 0 0 1 1 1 0 Phosphatidate cytidylyltransferase, mitochondrial Hormone_recep PF00104.30 EDO16824.1 - 0.054 13.1 3.3 0.059 12.9 3.3 1.1 1 0 0 1 1 1 0 Ligand-binding domain of nuclear hormone receptor tRNA-synt_2 PF00152.20 EDO16825.1 - 5.9e-75 252.2 0.0 7.5e-75 251.9 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 EDO16825.1 - 3.1e-09 36.7 0.1 6.7e-09 35.6 0.1 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 EDO16825.1 - 0.05 13.1 0.0 2.2 7.7 0.0 2.2 2 0 0 2 2 2 0 tRNA synthetases class II core domain (F) zf-Nse PF11789.8 EDO16826.1 - 5.2e-16 58.2 0.2 1.3e-15 56.9 0.2 1.7 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_UBOX PF13445.6 EDO16826.1 - 0.001 19.1 0.1 0.003 17.5 0.1 1.9 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 EDO16826.1 - 0.001 18.9 0.3 0.004 17.0 0.0 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) U-box PF04564.15 EDO16826.1 - 0.006 16.7 0.1 0.036 14.2 0.1 2.2 2 0 0 2 2 2 1 U-box domain zf-MIZ PF02891.20 EDO16826.1 - 0.045 13.5 0.2 0.14 11.9 0.0 2.0 2 0 0 2 2 2 0 MIZ/SP-RING zinc finger zf-RING_2 PF13639.6 EDO16826.1 - 0.053 13.9 0.2 0.21 12.0 0.2 2.1 1 0 0 1 1 1 0 Ring finger domain Diphthamide_syn PF01866.17 EDO16827.1 - 0.024 14.1 0.1 0.034 13.6 0.1 1.2 1 0 0 1 1 1 0 Putative diphthamide synthesis protein Phosphodiest PF01663.22 EDO16828.1 - 1.9e-85 287.6 0.5 2.9e-85 287.0 0.5 1.3 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 EDO16828.1 - 0.00037 20.0 2.8 0.00062 19.3 0.1 2.4 2 0 0 2 2 2 1 Sulfatase SDA1 PF05285.12 EDO16828.1 - 0.01 15.3 15.0 0.016 14.7 15.0 1.3 1 0 0 1 1 1 0 SDA1 CDC45 PF02724.14 EDO16828.1 - 0.024 12.9 11.0 0.036 12.4 11.0 1.1 1 0 0 1 1 1 0 CDC45-like protein Nop14 PF04147.12 EDO16828.1 - 0.11 10.7 20.7 0.16 10.1 20.7 1.1 1 0 0 1 1 1 0 Nop14-like family BSP_II PF05432.11 EDO16828.1 - 0.17 11.6 30.5 0.28 10.8 30.5 1.2 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) RR_TM4-6 PF06459.12 EDO16828.1 - 0.18 11.6 10.3 0.31 10.8 10.3 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Neur_chan_memb PF02932.16 EDO16828.1 - 0.24 11.4 2.9 0.4 10.7 2.9 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Tim54 PF11711.8 EDO16828.1 - 1.1 8.0 11.2 1.6 7.4 11.2 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DNA_pol_phi PF04931.13 EDO16828.1 - 5.6 4.9 14.2 11 4.0 14.2 1.4 1 0 0 1 1 1 0 DNA polymerase phi CSG2 PF16965.5 EDO16828.1 - 6.4 5.6 5.8 38 3.1 6.2 2.0 3 0 0 3 3 3 0 Ceramide synthase regulator Zip PF02535.22 EDO16828.1 - 6.7 5.8 9.3 11 5.1 9.3 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Spt20 PF12090.8 EDO16828.1 - 7 6.2 23.6 13 5.3 23.6 1.4 1 0 0 1 1 1 0 Spt20 family Trypan_PARP PF05887.11 EDO16828.1 - 7.5 6.5 8.9 13 5.7 8.9 1.3 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Presenilin PF01080.17 EDO16828.1 - 9.1 4.9 18.7 14 4.3 18.7 1.2 1 0 0 1 1 1 0 Presenilin Ras PF00071.22 EDO16829.1 - 8.4e-38 129.5 0.1 1.4e-37 128.8 0.1 1.3 1 1 0 1 1 1 1 Ras family Roc PF08477.13 EDO16829.1 - 4.9e-14 52.6 0.0 7.5e-14 52.0 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU PF00009.27 EDO16829.1 - 2.8e-07 30.3 0.1 3.4e-07 30.0 0.1 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Arf PF00025.21 EDO16829.1 - 4.5e-07 29.5 0.1 5.7e-07 29.1 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EDO16829.1 - 0.00087 19.4 0.0 0.0015 18.6 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase YjeF_N PF03853.15 EDO16830.1 - 1.9e-38 132.1 0.0 2.9e-38 131.4 0.0 1.3 1 0 0 1 1 1 1 YjeF-related protein N-terminus FDF PF09532.10 EDO16830.1 - 1.5e-09 38.7 12.1 1.5e-09 38.7 12.1 2.0 2 0 0 2 2 2 1 FDF domain RXT2_N PF08595.11 EDO16830.1 - 1.8 8.6 9.0 3.4 7.7 8.6 1.6 1 1 0 1 1 1 0 RXT2-like, N-terminal DNA_pol_phi PF04931.13 EDO16830.1 - 2.2 6.3 11.5 3.2 5.8 11.5 1.1 1 0 0 1 1 1 0 DNA polymerase phi Arm PF00514.23 EDO16831.1 - 6.5e-72 235.6 28.6 7.7e-12 44.8 0.0 11.1 11 1 1 12 12 12 8 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 EDO16831.1 - 3.7e-22 78.4 12.4 5.5e-05 23.6 0.1 8.7 7 2 2 9 9 9 5 HEAT-like repeat HEAT_2 PF13646.6 EDO16831.1 - 2e-17 63.3 6.5 0.00044 20.6 0.0 7.6 4 2 4 8 8 8 5 HEAT repeats HEAT PF02985.22 EDO16831.1 - 5.2e-12 44.9 25.5 0.094 13.0 0.3 9.8 11 0 0 11 11 10 4 HEAT repeat Adaptin_N PF01602.20 EDO16831.1 - 6.1e-12 44.9 8.0 4.4e-07 28.8 0.5 2.8 1 1 2 3 3 3 3 Adaptin N terminal region KAP PF05804.12 EDO16831.1 - 3.8e-11 41.9 1.1 1.5e-09 36.6 0.1 2.4 1 1 1 2 2 2 2 Kinesin-associated protein (KAP) Arm_2 PF04826.13 EDO16831.1 - 5.9e-10 39.0 8.9 1.2e-06 28.2 2.0 3.1 2 1 0 3 3 3 2 Armadillo-like V-ATPase_H_C PF11698.8 EDO16831.1 - 1.8e-06 28.0 2.7 0.089 12.9 0.0 5.2 2 1 5 7 7 7 2 V-ATPase subunit H DUF3361 PF11841.8 EDO16831.1 - 9.2e-06 25.7 4.8 0.04 13.8 0.1 4.3 2 1 1 4 4 4 1 Domain of unknown function (DUF3361) Cnd1 PF12717.7 EDO16831.1 - 6e-05 23.1 9.5 0.2 11.7 0.1 5.3 2 1 3 6 6 6 3 non-SMC mitotic condensation complex subunit 1 Tti2 PF10521.9 EDO16831.1 - 0.00012 21.8 0.1 0.02 14.4 0.0 3.1 3 0 0 3 3 3 1 Tti2 family Vac14_Fab1_bd PF12755.7 EDO16831.1 - 0.0002 21.9 0.2 1.8 9.2 0.0 3.6 3 1 0 3 3 2 2 Vacuolar 14 Fab1-binding region UNC45-central PF11701.8 EDO16831.1 - 0.036 14.0 6.3 5.8 6.9 0.1 3.7 2 1 2 4 4 4 0 Myosin-binding striated muscle assembly central Proteasom_PSMB PF10508.9 EDO16831.1 - 0.038 12.5 2.9 8.8 4.7 0.1 3.2 2 2 1 3 3 3 0 Proteasome non-ATPase 26S subunit RasGEF_N_2 PF14663.6 EDO16831.1 - 0.057 13.8 1.7 36 4.8 0.1 4.3 4 0 0 4 4 4 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain RIF5_SNase_1 PF18187.1 EDO16831.1 - 0.082 12.7 0.0 0.18 11.5 0.0 1.5 1 0 0 1 1 1 0 TbRIF5 SNase domain 1 zf-C3HC4_4 PF15227.6 EDO16831.1 - 7.4 6.8 6.4 1.8 8.8 0.1 2.9 3 0 0 3 3 3 0 zinc finger of C3HC4-type, RING CUE PF02845.16 EDO16832.1 - 8.9e-09 34.9 0.2 0.014 15.1 0.0 3.4 3 0 0 3 3 3 2 CUE domain Smr PF01713.21 EDO16832.1 - 0.0005 20.4 0.0 0.0012 19.2 0.0 1.6 1 0 0 1 1 1 1 Smr domain Big_6 PF17936.1 EDO16832.1 - 0.24 11.7 0.6 0.54 10.6 0.6 1.5 1 0 0 1 1 1 0 Bacterial Ig domain HECT PF00632.25 EDO16833.1 - 3.4e-73 246.8 0.5 7.6e-73 245.7 0.5 1.6 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Upf2 PF04050.14 EDO16833.1 - 0.012 16.3 0.4 0.031 15.0 0.4 1.6 1 0 0 1 1 1 0 Up-frameshift suppressor 2 DUF410 PF04190.13 EDO16833.1 - 0.014 15.2 0.1 0.045 13.6 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF410) RL10P_insert PF17777.1 EDO16834.1 - 6.7e-19 67.7 0.0 1.1e-18 66.9 0.0 1.4 1 0 0 1 1 1 1 Insertion domain in 60S ribosomal protein L10P Ribosomal_L10 PF00466.20 EDO16834.1 - 1.7e-17 63.4 0.0 3.1e-17 62.6 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L10 TRAM_LAG1_CLN8 PF03798.16 EDO16835.1 - 1.2e-40 139.4 24.7 1.2e-40 139.4 24.7 2.5 2 1 1 3 3 3 1 TLC domain TRAM1 PF08390.11 EDO16835.1 - 1.8e-20 72.3 3.2 1.8e-20 72.3 3.2 2.0 2 0 0 2 2 2 1 TRAM1-like protein DUF4834 PF16118.5 EDO16835.1 - 0.4 11.7 4.5 4.2 8.4 0.0 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) Herpes_LMP1 PF05297.11 EDO16835.1 - 4.6 6.3 6.7 9.9 5.2 6.7 1.6 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) VHS PF00790.19 EDO16836.1 - 1.4e-32 112.4 2.6 2e-32 112.0 1.9 1.7 2 0 0 2 2 2 1 VHS domain SH3_1 PF00018.28 EDO16836.1 - 1.9e-15 56.2 0.0 3.5e-15 55.3 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 EDO16836.1 - 4.2e-12 45.5 0.0 8.3e-12 44.6 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 EDO16836.1 - 1.6e-11 43.8 0.0 3.1e-11 42.9 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain GAT PF03127.14 EDO16836.1 - 3.3e-07 30.5 2.7 3.7e-07 30.4 0.7 2.3 2 0 0 2 2 2 1 GAT domain Hrs_helical PF12210.8 EDO16836.1 - 0.0029 18.1 0.9 0.0074 16.8 0.3 2.0 2 0 0 2 2 2 1 Hepatocyte growth factor-regulated tyrosine kinase substrate UIM PF02809.20 EDO16836.1 - 0.022 14.7 0.7 0.022 14.7 0.7 2.1 2 0 0 2 2 2 0 Ubiquitin interaction motif NHase_beta PF02211.15 EDO16836.1 - 0.38 10.8 4.7 0.081 12.9 0.7 1.8 2 0 0 2 2 2 0 Nitrile hydratase beta subunit Suf PF05843.14 EDO16836.1 - 0.81 9.6 27.5 1.5 8.7 10.9 2.3 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) F-actin_cap_A PF01267.17 EDO16837.1 - 1.9e-78 263.6 3.6 2.1e-78 263.4 3.6 1.0 1 0 0 1 1 1 1 F-actin capping protein alpha subunit DUF5344 PF17279.2 EDO16837.1 - 0.023 15.3 0.9 0.083 13.5 0.3 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5344) MapZ_EC1 PF18041.1 EDO16838.1 - 0.011 16.0 0.2 0.014 15.6 0.2 1.1 1 0 0 1 1 1 0 MapZ extracellular domain 1 DUF2207 PF09972.9 EDO16838.1 - 0.026 13.3 0.4 0.026 13.3 0.4 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) CK2S PF15011.6 EDO16838.1 - 0.06 13.2 0.3 0.11 12.4 0.3 1.4 1 1 0 1 1 1 0 Casein Kinase 2 substrate Synaptobrevin PF00957.21 EDO16838.1 - 0.06 13.1 2.5 0.19 11.5 2.1 1.9 1 1 1 2 2 2 0 Synaptobrevin Latarcin PF10279.9 EDO16838.1 - 0.083 13.3 0.9 0.25 11.8 0.9 1.8 1 1 0 1 1 1 0 Latarcin precursor Orf78 PF06024.12 EDO16838.1 - 0.089 13.1 0.1 0.11 12.8 0.1 1.1 1 0 0 1 1 1 0 Orf78 (ac78) Ribosomal_L14e PF01929.17 EDO16839.1 - 3.8e-32 110.6 1.2 6.4e-32 109.9 1.2 1.4 1 0 0 1 1 1 1 Ribosomal protein L14 KOW PF00467.29 EDO16839.1 - 0.00026 20.8 0.7 0.0006 19.7 0.7 1.6 1 0 0 1 1 1 1 KOW motif PAP2_3 PF14378.6 EDO16840.1 - 6.6e-25 87.9 10.2 6.6e-25 87.9 10.2 2.0 2 0 0 2 2 2 1 PAP2 superfamily PAP2 PF01569.21 EDO16840.1 - 2.2e-09 37.2 5.5 2.2e-09 37.2 5.5 2.5 2 1 1 3 3 3 1 PAP2 superfamily Dynamin_M PF01031.20 EDO16841.1 - 1.6e-99 332.7 1.0 2.5e-99 332.1 0.2 1.8 2 0 0 2 2 2 1 Dynamin central region Dynamin_N PF00350.23 EDO16841.1 - 1.8e-54 184.3 0.2 4.8e-54 182.9 0.2 1.8 1 0 0 1 1 1 1 Dynamin family GED PF02212.18 EDO16841.1 - 3.9e-29 100.6 4.0 9.8e-29 99.4 4.0 1.7 1 0 0 1 1 1 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.23 EDO16841.1 - 0.00041 20.4 0.4 0.0014 18.7 0.4 2.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase CHASE6_C PF17150.4 EDO16841.1 - 0.16 12.7 0.2 0.84 10.3 0.0 2.4 2 0 0 2 2 2 0 C-terminal domain of two-partite extracellular sensor domain PAP_central PF04928.17 EDO16842.1 - 9e-112 372.0 0.0 1.6e-111 371.2 0.0 1.4 1 0 0 1 1 1 1 Poly(A) polymerase central domain PAP_RNA-bind PF04926.15 EDO16842.1 - 6.6e-54 182.1 0.7 1.3e-53 181.2 0.7 1.5 1 0 0 1 1 1 1 Poly(A) polymerase predicted RNA binding domain NTP_transf_2 PF01909.23 EDO16842.1 - 6.4e-15 55.2 0.7 2.2e-14 53.5 0.1 2.2 2 0 0 2 2 2 1 Nucleotidyltransferase domain Polbeta PF18765.1 EDO16842.1 - 0.0024 17.9 0.1 0.012 15.7 0.0 2.3 2 0 0 2 2 2 1 Polymerase beta, Nucleotidyltransferase DUF4850 PF16142.5 EDO16842.1 - 0.072 12.6 0.0 0.15 11.5 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4850) JAB PF01398.21 EDO16843.1 - 4.9e-32 110.4 0.3 4.9e-32 110.4 0.3 2.0 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.6 EDO16843.1 - 6.4e-11 42.7 1.9 1.6e-10 41.4 1.9 1.7 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function Prok-JAB PF14464.6 EDO16843.1 - 2.7e-07 30.4 0.0 4.3e-07 29.7 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain UCH PF00443.29 EDO16844.1 - 2.3e-14 53.5 2.8 2.3e-14 53.5 1.7 1.5 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 EDO16844.1 - 8.3e-12 45.3 0.2 1.6e-11 44.4 0.2 1.5 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein UCH_1 PF13423.6 EDO16844.1 - 0.065 12.8 0.0 0.065 12.8 0.0 2.5 2 1 0 3 3 3 0 Ubiquitin carboxyl-terminal hydrolase Peptidase_M24 PF00557.24 EDO16845.1 - 7.3e-59 199.0 0.0 1e-58 198.5 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.16 EDO16845.1 - 2.9e-24 85.1 0.0 7.5e-24 83.8 0.0 1.7 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain DUF3793 PF12672.7 EDO16845.1 - 0.023 14.8 0.1 0.056 13.5 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3793) Ribonuc_red_sm PF00268.21 EDO16846.1 - 7.2e-72 242.2 2.8 9.2e-72 241.8 2.8 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, small chain MMR_HSR1_Xtn PF16897.5 EDO16847.1 - 1.6e-36 124.5 1.8 3.1e-36 123.6 1.8 1.5 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain MMR_HSR1 PF01926.23 EDO16847.1 - 2.5e-21 75.9 0.1 5.5e-21 74.8 0.1 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase TGS PF02824.21 EDO16847.1 - 2.9e-20 72.1 0.0 6.3e-20 71.0 0.0 1.6 1 0 0 1 1 1 1 TGS domain FeoB_N PF02421.18 EDO16847.1 - 5.7e-13 48.7 0.0 9.4e-13 48.0 0.0 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 EDO16847.1 - 0.00013 22.1 0.6 0.059 13.4 0.0 2.4 1 1 1 2 2 2 2 Dynamin family AIG1 PF04548.16 EDO16847.1 - 0.00037 19.9 0.1 0.00064 19.1 0.1 1.4 1 0 0 1 1 1 1 AIG1 family SRPRB PF09439.10 EDO16847.1 - 0.001 18.5 1.2 0.0069 15.8 0.0 2.2 1 1 0 2 2 2 1 Signal recognition particle receptor beta subunit Roc PF08477.13 EDO16847.1 - 0.016 15.4 0.9 0.11 12.8 0.1 2.5 1 1 1 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase MCM PF00493.23 EDO16847.1 - 0.02 14.0 0.2 0.11 11.6 0.0 2.0 2 0 0 2 2 2 0 MCM P-loop domain Ras PF00071.22 EDO16847.1 - 0.093 12.3 0.4 1.4 8.5 0.0 2.2 2 0 0 2 2 2 0 Ras family AAA_16 PF13191.6 EDO16847.1 - 0.11 12.9 0.2 0.25 11.7 0.2 1.6 1 1 0 1 1 1 0 AAA ATPase domain RsgA_GTPase PF03193.16 EDO16847.1 - 0.17 11.8 1.2 1.5 8.7 0.1 2.8 2 1 1 3 3 3 0 RsgA GTPase Retrotrans_gag PF03732.17 EDO16848.1 - 3.7e-07 30.3 0.1 6.1e-07 29.6 0.1 1.3 1 0 0 1 1 1 1 Retrotransposon gag protein zf-CCHC PF00098.23 EDO16848.1 - 0.00044 20.2 3.0 0.00071 19.5 3.0 1.3 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_2 PF13696.6 EDO16848.1 - 0.0014 18.4 1.0 0.0023 17.7 1.0 1.4 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_5 PF14787.6 EDO16848.1 - 0.0031 17.2 1.6 0.0062 16.2 1.6 1.4 1 0 0 1 1 1 1 GAG-polyprotein viral zinc-finger Flocculin PF00624.18 EDO16849.1 - 1.9e-99 325.7 482.9 4.9e-10 39.5 18.2 72.7 34 3 38 72 72 72 25 Flocculin repeat DUF2000 PF09391.10 EDO16849.1 - 0.018 15.0 10.8 26 4.7 0.0 7.8 3 3 1 8 8 8 0 Protein of unknown function (DUF2000) Homoserine_dh PF00742.19 EDO16850.1 - 1.9e-51 174.4 0.0 2.4e-51 174.1 0.0 1.1 1 0 0 1 1 1 1 Homoserine dehydrogenase NAD_binding_3 PF03447.16 EDO16850.1 - 5.9e-23 81.7 0.0 1.1e-22 80.9 0.0 1.4 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain F420_oxidored PF03807.17 EDO16850.1 - 0.054 14.1 0.0 0.15 12.6 0.0 1.8 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent VWA_2 PF13519.6 EDO16851.1 - 2.9e-18 66.5 1.7 6.6e-18 65.3 0.1 2.3 3 0 0 3 3 3 1 von Willebrand factor type A domain Ssl1 PF04056.14 EDO16851.1 - 1.9e-07 31.1 1.0 2.9e-07 30.5 1.0 1.3 1 0 0 1 1 1 1 Ssl1-like VWA PF00092.28 EDO16851.1 - 3.2e-05 24.2 2.3 4.6e-05 23.7 2.3 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain Ku_N PF03731.15 EDO16851.1 - 0.00066 19.5 1.0 0.00066 19.5 1.0 2.1 3 0 0 3 3 3 1 Ku70/Ku80 N-terminal alpha/beta domain zf-Tim10_DDP PF02953.15 EDO16852.1 - 6.6e-09 35.3 0.1 6.7e-09 35.3 0.1 1.0 1 0 0 1 1 1 1 Tim10/DDP family zinc finger Rsd_AlgQ PF04353.13 EDO16853.1 - 0.0066 16.4 0.5 0.013 15.4 0.5 1.5 1 0 0 1 1 1 1 Regulator of RNA polymerase sigma(70) subunit, Rsd/AlgQ LMBR1 PF04791.16 EDO16853.1 - 0.23 10.3 0.7 0.26 10.1 0.7 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein RIX1 PF08167.12 EDO16854.1 - 5.5e-52 176.3 7.5 5.5e-52 176.3 7.5 2.0 2 0 0 2 2 2 1 rRNA processing/ribosome biogenesis Nebulin PF00880.18 EDO16854.1 - 0.034 14.1 0.5 0.09 12.7 0.5 1.8 1 0 0 1 1 1 0 Nebulin repeat ASXH PF13919.6 EDO16854.1 - 0.072 13.1 1.6 0.35 10.9 0.2 2.4 2 0 0 2 2 2 0 Asx homology domain Pet20 PF08692.10 EDO16854.1 - 0.27 11.9 2.4 1.5 9.6 0.0 3.0 3 0 0 3 3 3 0 Mitochondrial protein Pet20 DUF1827 PF08860.10 EDO16854.1 - 0.37 11.1 3.2 1.4 9.2 3.2 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF1827) DUF5365 PF17326.2 EDO16855.1 - 0.0015 19.0 1.7 0.0025 18.2 1.7 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF5365) PIP5K PF01504.18 EDO16856.1 - 1.6e-43 148.9 10.6 1.8e-36 125.8 2.4 3.5 2 1 1 3 3 3 2 Phosphatidylinositol-4-phosphate 5-Kinase Cpn60_TCP1 PF00118.24 EDO16856.1 - 1.5e-30 106.3 0.1 3.5e-30 105.1 0.1 1.5 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family FYVE PF01363.21 EDO16856.1 - 3.3e-17 62.4 9.7 3.3e-17 62.4 9.7 2.4 3 0 0 3 3 3 1 FYVE zinc finger zf-RING_2 PF13639.6 EDO16856.1 - 0.57 10.6 8.8 1.7 9.1 8.8 1.9 1 0 0 1 1 1 0 Ring finger domain IBR PF01485.21 EDO16856.1 - 1.4 9.2 10.5 0.33 11.2 5.9 2.3 2 0 0 2 2 2 0 IBR domain, a half RING-finger domain DZR PF12773.7 EDO16856.1 - 1.8 8.7 11.3 0.71 9.9 0.4 3.3 2 1 1 3 3 3 0 Double zinc ribbon C1_2 PF03107.16 EDO16856.1 - 7.5 7.0 9.2 4.8 7.6 6.6 2.1 2 0 0 2 2 2 0 C1 domain Peptidase_M28 PF04389.17 EDO16857.1 - 2.5e-28 99.1 0.0 3.5e-28 98.6 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M28 TIP120 PF08623.10 EDO16858.1 - 7.2e-06 25.9 0.3 7.2e-06 25.9 0.3 2.7 3 1 0 3 3 3 1 TATA-binding protein interacting (TIP20) GTP_EFTU PF00009.27 EDO16860.1 - 4.4e-29 101.4 10.1 2.1e-28 99.2 6.3 2.7 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain IF-2 PF11987.8 EDO16860.1 - 3.9e-26 91.2 1.1 1.2e-25 89.7 1.1 1.9 1 0 0 1 1 1 1 Translation-initiation factor 2 MMR_HSR1 PF01926.23 EDO16860.1 - 3.3e-08 33.6 0.6 1.1e-07 31.9 0.6 2.0 1 0 0 1 1 1 1 50S ribosome-binding GTPase IF2_N PF04760.15 EDO16860.1 - 3.7e-08 33.1 0.0 1e-07 31.6 0.0 1.9 1 0 0 1 1 1 1 Translation initiation factor IF-2, N-terminal region GTP_EFTU_D2 PF03144.25 EDO16860.1 - 5.5e-05 23.5 6.3 0.03 14.7 0.3 3.8 2 1 0 2 2 2 2 Elongation factor Tu domain 2 Ras PF00071.22 EDO16860.1 - 0.0027 17.3 0.1 0.0063 16.1 0.1 1.6 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EDO16860.1 - 0.0055 16.9 0.1 0.015 15.5 0.1 1.8 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 EDO16860.1 - 0.011 15.1 0.2 0.011 15.1 0.2 1.9 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit Dynamin_N PF00350.23 EDO16860.1 - 0.013 15.5 4.5 2.4 8.2 0.1 4.2 3 1 1 4 4 4 0 Dynamin family DUF4611 PF15387.6 EDO16860.1 - 0.034 14.4 3.4 0.53 10.5 1.7 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) PDCD2_C PF04194.13 EDO16861.1 - 4.6e-42 144.1 2.6 2.6e-40 138.4 0.0 3.0 3 0 0 3 3 3 2 Programmed cell death protein 2, C-terminal putative domain Menin PF05053.13 EDO16861.1 - 0.4 9.0 2.5 0.5 8.7 2.5 1.1 1 0 0 1 1 1 0 Menin Macoilin PF09726.9 EDO16862.1 - 0.16 10.5 13.4 0.2 10.2 13.4 1.1 1 0 0 1 1 1 0 Macoilin family BBP1_N PF15271.6 EDO16862.1 - 0.51 11.1 10.5 1.2 9.9 10.5 1.7 1 0 0 1 1 1 0 Spindle pole body component BBP1, Mps2-binding protein ubiquitin PF00240.23 EDO16863.1 - 1.5e-34 117.5 0.5 3e-34 116.6 0.5 1.5 1 0 0 1 1 1 1 Ubiquitin family Ribosomal_S27 PF01599.19 EDO16863.1 - 8.9e-24 83.4 2.6 8.9e-24 83.4 2.6 1.8 2 0 0 2 2 2 1 Ribosomal protein S27a Rad60-SLD PF11976.8 EDO16863.1 - 7.1e-16 57.8 0.6 7.1e-16 57.8 0.6 1.8 2 1 1 3 3 3 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EDO16863.1 - 2.4e-05 24.7 0.2 0.00013 22.4 0.1 2.1 2 1 0 2 2 2 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 EDO16863.1 - 0.0011 19.1 0.6 0.0027 17.8 0.6 1.7 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_5 PF18037.1 EDO16863.1 - 0.0051 17.2 0.7 0.012 16.0 0.0 1.8 1 1 1 2 2 2 1 Ubiquitin-like domain TBK1_ULD PF18396.1 EDO16863.1 - 0.0064 16.4 0.0 0.0099 15.8 0.0 1.3 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain DUF2407 PF10302.9 EDO16863.1 - 0.015 15.9 0.6 0.019 15.5 0.6 1.3 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain Ubiquitin_4 PF18036.1 EDO16863.1 - 0.017 15.2 1.1 5.4 7.1 0.2 2.5 2 0 0 2 2 2 0 Ubiquitin-like domain Thioredoxin PF00085.20 EDO16864.1 - 0.077 13.0 0.0 0.13 12.3 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin Sec10 PF07393.11 EDO16865.1 - 7.8e-189 629.5 32.3 1e-188 629.1 32.3 1.1 1 0 0 1 1 1 1 Exocyst complex component Sec10 SAS4 PF15460.6 EDO16866.1 - 1.9e-29 101.7 13.0 2.4e-29 101.4 7.0 2.9 2 0 0 2 2 2 1 Something about silencing, SAS, complex subunit 4 CNOT11 PF10155.9 EDO16866.1 - 0.064 13.4 0.1 0.14 12.3 0.1 1.5 1 0 0 1 1 1 0 CCR4-NOT transcription complex subunit 11 CybS PF05328.12 EDO16868.1 - 9e-50 167.8 0.0 1.1e-49 167.6 0.0 1.0 1 0 0 1 1 1 1 CybS, succinate dehydrogenase cytochrome B small subunit DUF3185 PF11381.8 EDO16868.1 - 0.12 12.5 0.0 0.2 11.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3185) Peptidase_M16 PF00675.20 EDO16869.1 - 1.4e-52 177.6 0.0 4.6e-52 176.0 0.1 1.9 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 EDO16869.1 - 4.9e-39 134.2 0.1 8.6e-35 120.4 0.0 3.1 3 0 0 3 3 3 2 Peptidase M16 inactive domain M16C_assoc PF08367.11 EDO16869.1 - 0.019 14.1 0.4 0.046 12.8 0.1 1.8 2 0 0 2 2 2 0 Peptidase M16C associated PcfK PF14058.6 EDO16869.1 - 0.04 14.2 0.0 0.084 13.1 0.0 1.5 1 0 0 1 1 1 0 PcfK-like protein DUF327 PF03885.13 EDO16869.1 - 0.098 12.6 1.7 0.24 11.4 1.7 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF327) HMG_box PF00505.19 EDO16870.1 - 7.7e-11 42.3 4.8 7.7e-11 42.3 4.8 2.1 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EDO16870.1 - 1.2e-07 32.2 3.5 1.2e-07 32.2 3.5 1.9 2 0 0 2 2 2 1 HMG-box domain Transketolase_N PF00456.21 EDO16870.1 - 0.012 14.6 0.7 0.018 14.0 0.7 1.2 1 0 0 1 1 1 0 Transketolase, thiamine diphosphate binding domain IPK PF03770.16 EDO16871.1 - 3.2e-57 193.6 0.2 5.5e-57 192.8 0.2 1.4 1 0 0 1 1 1 1 Inositol polyphosphate kinase HSP20 PF00011.21 EDO16872.1 - 7.8e-07 29.2 0.3 2.1e-06 27.8 0.0 1.8 2 0 0 2 2 2 1 Hsp20/alpha crystallin family Ceramidase PF05875.12 EDO16873.1 - 6.2e-91 304.5 20.7 7.2e-91 304.2 20.7 1.0 1 0 0 1 1 1 1 Ceramidase DUF4199 PF13858.6 EDO16873.1 - 0.0071 16.8 0.5 0.0071 16.8 0.5 2.6 2 1 1 3 3 3 1 Protein of unknown function (DUF4199) DUF3792 PF12670.7 EDO16873.1 - 3.7 7.7 15.3 0.046 13.9 5.1 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF3792) Radical_SAM_C PF16199.5 EDO16874.1 - 3.5e-32 110.2 0.0 7e-32 109.3 0.0 1.5 1 0 0 1 1 1 1 Radical_SAM C-terminal domain Radical_SAM PF04055.21 EDO16874.1 - 1.6e-19 70.9 0.2 5.4e-19 69.2 0.1 1.8 2 0 0 2 2 2 1 Radical SAM superfamily Acetyltransf_1 PF00583.25 EDO16874.1 - 2.3e-10 40.8 0.1 4.1e-10 39.9 0.1 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EDO16874.1 - 2.9e-06 27.2 0.1 9.4e-06 25.6 0.0 1.8 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EDO16874.1 - 0.011 16.1 0.1 0.023 15.1 0.1 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Sec16_C PF12931.7 EDO16875.1 - 2.6e-24 86.4 0.2 5.3e-24 85.4 0.2 1.5 1 0 0 1 1 1 1 Sec23-binding domain of Sec16 MBA1 PF07961.11 EDO16876.1 - 1.7e-97 325.1 3.7 2.1e-97 324.8 3.7 1.0 1 0 0 1 1 1 1 MBA1-like protein SRP72 PF08492.12 EDO16876.1 - 6.2 7.3 6.6 28 5.3 0.3 2.9 3 0 0 3 3 3 0 SRP72 RNA-binding domain BRO1 PF03097.18 EDO16877.1 - 8.5e-87 291.5 8.9 8.5e-87 291.5 8.9 1.8 2 0 0 2 2 2 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.6 EDO16877.1 - 1.2e-26 93.7 11.8 3.5e-26 92.2 11.5 2.0 1 1 0 1 1 1 1 ALIX V-shaped domain binding to HIV UPF0016 PF01169.19 EDO16878.1 - 7.2e-41 138.4 20.8 1.1e-20 73.7 6.5 2.3 2 0 0 2 2 2 2 Uncharacterized protein family UPF0016 Imm70 PF15601.6 EDO16878.1 - 0.011 15.3 0.0 0.02 14.5 0.0 1.3 1 0 0 1 1 1 0 Immunity protein 70 cwf18 PF08315.12 EDO16879.1 - 9.6e-06 26.3 8.5 1.3e-05 25.9 8.5 1.2 1 0 0 1 1 1 1 cwf18 pre-mRNA splicing factor DUF4661 PF15576.6 EDO16879.1 - 0.3 11.0 3.9 1.4 8.8 2.7 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4661) S4 PF01479.25 EDO16880.1 - 6.3e-13 48.2 0.2 6.3e-13 48.2 0.2 2.0 2 0 0 2 2 2 1 S4 domain Ribosomal_L21e PF01157.18 EDO16881.1 - 2.4e-48 162.2 5.9 2.4e-48 162.2 5.9 1.7 2 0 0 2 2 2 1 Ribosomal protein L21e LRS4 PF10422.9 EDO16881.1 - 0.0084 15.7 0.1 0.01 15.4 0.1 1.1 1 0 0 1 1 1 1 Monopolin complex subunit LRS4 SIMPL PF04402.14 EDO16881.1 - 0.013 15.9 0.1 0.017 15.6 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF541) Mito_carr PF00153.27 EDO16882.1 - 6.4e-75 247.2 3.6 9.4e-28 96.0 0.2 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Med8 PF10232.9 EDO16883.1 - 2.2e-15 56.9 0.4 2.5e-15 56.7 0.4 1.2 1 0 0 1 1 1 1 Mediator of RNA polymerase II transcription complex subunit 8 NPV_P10 PF05531.12 EDO16883.1 - 0.012 16.1 2.0 0.83 10.2 0.0 2.9 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein Mt_ATP-synt_B PF05405.14 EDO16884.1 - 5.1e-55 185.5 10.5 6.3e-55 185.2 10.5 1.1 1 0 0 1 1 1 1 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) DUF2605 PF10792.9 EDO16884.1 - 0.019 14.8 0.5 0.048 13.6 0.5 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2605) CAF1C_H4-bd PF12265.8 EDO16885.1 - 1.3e-17 63.8 1.3 5.2e-17 61.9 1.1 2.2 3 0 0 3 3 3 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 EDO16885.1 - 6.8e-16 58.4 14.4 0.0012 19.6 1.1 6.5 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDO16885.1 - 3.4e-10 40.1 1.1 0.02 15.2 0.0 4.9 3 2 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EDO16885.1 - 1.8e-06 28.0 0.3 0.00011 22.2 0.0 3.1 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 EDO16885.1 - 3.1e-05 22.8 0.2 4.8e-05 22.2 0.2 1.4 1 0 0 1 1 1 1 Nucleoporin Nup120/160 Coatomer_WDAD PF04053.14 EDO16885.1 - 0.0016 17.5 0.0 0.098 11.7 0.0 2.1 1 1 1 2 2 2 2 Coatomer WD associated region Itfg2 PF15907.5 EDO16885.1 - 0.0059 15.7 0.0 0.011 14.8 0.0 1.4 1 0 0 1 1 1 1 Integrin-alpha FG-GAP repeat-containing protein 2 BBS2_N PF14781.6 EDO16885.1 - 0.089 12.7 0.0 0.85 9.5 0.0 2.3 2 0 0 2 2 2 0 Ciliary BBSome complex subunit 2, N-terminal PGI PF00342.19 EDO16886.1 - 6.8e-243 806.6 1.9 7.8e-243 806.4 1.9 1.0 1 0 0 1 1 1 1 Phosphoglucose isomerase Lipoprotein_18 PF06804.11 EDO16886.1 - 0.082 11.9 0.0 0.17 10.9 0.0 1.5 1 0 0 1 1 1 0 NlpB/DapX lipoprotein DUF5315 PF17242.2 EDO16887.1 - 9.5e-27 92.6 1.2 2.7e-26 91.2 1.2 1.8 1 0 0 1 1 1 1 Disordered region of unknown function (DUF5315) COG5 PF10392.9 EDO16887.1 - 0.0032 17.6 0.1 0.0032 17.6 0.1 2.1 3 0 0 3 3 3 1 Golgi transport complex subunit 5 GTP_EFTU_D3 PF03143.17 EDO16887.1 - 0.074 13.4 0.4 0.14 12.4 0.2 1.8 2 0 0 2 2 2 0 Elongation factor Tu C-terminal domain DUF2018 PF09442.10 EDO16887.1 - 0.33 11.9 4.9 4.7 8.2 0.4 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF2018) Snapin_Pallidin PF14712.6 EDO16887.1 - 1.3 9.4 8.8 0.97 9.9 5.0 2.7 2 1 1 3 3 3 0 Snapin/Pallidin WD40 PF00400.32 EDO16888.1 - 2.1e-49 164.4 18.6 1.2e-08 35.5 0.9 6.6 6 0 0 6 6 6 6 WD domain, G-beta repeat TFIID_NTD2 PF04494.15 EDO16888.1 - 8.8e-41 139.2 2.8 2.2e-40 137.9 2.8 1.7 1 0 0 1 1 1 1 WD40 associated region in TFIID subunit, NTD2 domain ANAPC4_WD40 PF12894.7 EDO16888.1 - 4.4e-15 55.7 0.1 0.13 12.5 0.0 6.1 1 1 4 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain LisH PF08513.11 EDO16888.1 - 1.1e-07 31.5 0.1 2.5e-07 30.4 0.1 1.6 1 0 0 1 1 1 1 LisH Ge1_WD40 PF16529.5 EDO16888.1 - 3.1e-07 29.7 0.1 0.44 9.5 0.0 4.7 1 1 2 4 4 4 4 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 EDO16888.1 - 3.4e-07 30.4 4.5 0.00017 21.5 0.7 3.0 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 EDO16888.1 - 0.00018 21.0 0.4 7.3 5.8 0.0 3.9 3 1 1 4 4 4 3 WD40-like domain Cytochrom_D1 PF02239.16 EDO16888.1 - 0.037 12.5 0.1 0.12 10.9 0.0 1.9 2 0 0 2 2 2 0 Cytochrome D1 heme domain DUF3788 PF12663.7 EDO16889.1 - 0.091 12.7 0.3 0.21 11.6 0.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3788) UCH PF00443.29 EDO16890.1 - 5.9e-34 117.7 7.9 7.5e-34 117.4 7.9 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EDO16890.1 - 6.1e-07 29.3 10.2 1.6e-05 24.7 10.2 2.3 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Caenor_Her-1 PF09232.10 EDO16890.1 - 0.059 13.5 1.0 51 4.0 0.0 3.4 3 0 0 3 3 3 0 Caenorhabditis elegans Her-1 SH3_1 PF00018.28 EDO16891.1 - 2.5e-22 78.2 0.0 1.7e-10 40.4 0.0 2.8 3 0 0 3 3 3 2 SH3 domain SH3_9 PF14604.6 EDO16891.1 - 5.8e-17 61.3 0.1 4.4e-11 42.5 0.0 2.8 2 0 0 2 2 2 2 Variant SH3 domain PX PF00787.24 EDO16891.1 - 1.1e-15 57.6 0.0 2.2e-15 56.6 0.0 1.5 1 0 0 1 1 1 1 PX domain SH3_2 PF07653.17 EDO16891.1 - 1.7e-09 37.2 0.1 1.3e-07 31.2 0.0 3.1 3 0 0 3 3 3 1 Variant SH3 domain PB1 PF00564.24 EDO16891.1 - 0.056 13.4 0.0 0.13 12.3 0.0 1.6 1 0 0 1 1 1 0 PB1 domain VPS9 PF02204.18 EDO16893.1 - 4.2e-18 65.5 3.7 6.8e-18 64.8 2.7 1.9 2 0 0 2 2 2 1 Vacuolar sorting protein 9 (VPS9) domain Sigma70_r1_1 PF03979.14 EDO16893.1 - 0.041 14.0 1.4 5.5 7.1 0.0 2.7 2 0 0 2 2 2 0 Sigma-70 factor, region 1.1 ATP-synt_ab PF00006.25 EDO16896.1 - 6.8e-114 378.8 0.0 5.6e-113 375.8 0.0 2.5 1 1 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain Hom_end_hint PF05203.16 EDO16896.1 - 2.4e-83 279.6 0.2 4.3e-83 278.7 0.2 1.5 1 0 0 1 1 1 1 Hom_end-associated Hint ATP-synt_ab_Xtn PF16886.5 EDO16896.1 - 2.1e-47 159.9 0.0 4.7e-47 158.8 0.0 1.6 1 0 0 1 1 1 1 ATPsynthase alpha/beta subunit N-term extension Hom_end PF05204.14 EDO16896.1 - 8.7e-45 151.4 0.4 6e-33 113.3 0.1 2.6 2 0 0 2 2 2 2 Homing endonuclease ATP-synt_ab_N PF02874.23 EDO16896.1 - 4.3e-16 59.2 2.5 1.2e-15 57.7 2.5 1.9 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain LAGLIDADG_3 PF14528.6 EDO16896.1 - 1.4e-07 31.7 0.1 0.00035 20.8 0.0 2.6 2 0 0 2 2 2 2 LAGLIDADG-like domain Hint PF01079.20 EDO16896.1 - 0.00041 19.9 0.0 0.00098 18.7 0.0 1.6 1 0 0 1 1 1 1 Hint module Hint_2 PF13403.6 EDO16896.1 - 0.0017 18.7 0.0 0.0068 16.7 0.0 2.1 1 0 0 1 1 1 1 Hint domain LAGLIDADG_WhiA PF14527.6 EDO16896.1 - 0.038 14.1 0.0 0.24 11.5 0.0 2.3 2 0 0 2 2 2 0 WhiA LAGLIDADG-like domain Vint PF14623.6 EDO16896.1 - 0.11 12.3 0.0 0.38 10.6 0.0 1.9 2 0 0 2 2 2 0 Hint-domain WhiA_N PF10298.9 EDO16896.1 - 0.12 12.4 0.0 1.3 9.2 0.0 2.4 2 0 0 2 2 2 0 WhiA N-terminal LAGLIDADG-like domain SUB1_ProdP9 PF18213.1 EDO16896.1 - 0.17 11.7 1.2 0.67 9.8 0.3 2.3 2 0 0 2 2 2 0 SUB1 protease Prodomain ProdP9 Ribosomal_L41 PF05162.13 EDO16897.1 - 1.3e-11 44.3 26.2 1.4e-11 44.3 26.2 1.0 1 0 0 1 1 1 1 Ribosomal protein L41 IATP PF04568.12 EDO16899.1 - 5.5e-16 58.8 1.2 6.2e-16 58.6 1.2 1.1 1 0 0 1 1 1 1 Mitochondrial ATPase inhibitor, IATP Fib_alpha PF08702.10 EDO16899.1 - 0.0046 17.1 0.4 0.0047 17.1 0.4 1.2 1 0 0 1 1 1 1 Fibrinogen alpha/beta chain family TRAF_BIRC3_bd PF16673.5 EDO16899.1 - 0.012 15.3 3.1 0.019 14.7 3.1 1.4 1 0 0 1 1 1 0 TNF receptor-associated factor BIRC3 binding domain DUF4140 PF13600.6 EDO16899.1 - 0.14 12.6 1.7 0.17 12.3 1.7 1.2 1 0 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) DivIC PF04977.15 EDO16899.1 - 0.84 9.4 7.2 1.1 9.1 6.9 1.4 1 1 0 1 1 1 0 Septum formation initiator Cyclin_N PF00134.23 EDO16902.1 - 6.5e-16 58.2 0.0 1e-15 57.6 0.0 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.11 EDO16902.1 - 2.5e-05 24.7 0.0 2.5e-05 24.7 0.0 2.2 2 1 0 2 2 2 1 Cyclin AAA PF00004.29 EDO16903.1 - 1.4e-99 329.6 0.0 1.7e-48 164.4 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EDO16903.1 - 2.3e-25 88.1 6.0 1.8e-13 50.0 1.3 2.8 2 0 0 2 2 2 2 AAA+ lid domain CDC48_N PF02359.18 EDO16903.1 - 8e-18 64.4 0.4 2.1e-17 63.1 0.4 1.8 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), N-terminal domain AAA_2 PF07724.14 EDO16903.1 - 2.2e-15 57.2 0.0 3.1e-07 30.7 0.0 2.8 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 EDO16903.1 - 6.6e-14 52.0 0.0 1.2e-05 25.2 0.0 2.9 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EDO16903.1 - 8.3e-13 49.1 0.1 0.00017 22.0 0.2 4.5 2 2 0 2 2 2 2 AAA ATPase domain AAA_33 PF13671.6 EDO16903.1 - 1.6e-11 44.5 0.0 1.1e-05 25.7 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_5 PF07728.14 EDO16903.1 - 1.8e-11 44.2 3.2 7.6e-06 26.0 0.1 3.9 3 2 0 3 3 2 2 AAA domain (dynein-related subfamily) CDC48_2 PF02933.17 EDO16903.1 - 3.9e-09 36.2 0.0 1e-08 34.8 0.0 1.8 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), domain 2 TIP49 PF06068.13 EDO16903.1 - 5e-09 35.8 1.1 0.0016 17.8 0.0 2.6 3 0 0 3 3 2 2 TIP49 P-loop domain AAA_22 PF13401.6 EDO16903.1 - 1.1e-08 35.5 1.3 0.069 13.4 0.0 4.2 2 2 1 3 3 3 2 AAA domain RNA_helicase PF00910.22 EDO16903.1 - 1.2e-07 32.1 0.0 0.0053 17.1 0.0 3.0 2 0 0 2 2 2 2 RNA helicase AAA_14 PF13173.6 EDO16903.1 - 2e-07 31.1 0.0 0.025 14.6 0.0 3.3 3 0 0 3 3 3 2 AAA domain Vps4_C PF09336.10 EDO16903.1 - 3.3e-07 30.2 0.7 3.8e-05 23.6 0.1 3.3 3 1 1 4 4 2 1 Vps4 C terminal oligomerisation domain Mg_chelatase PF01078.21 EDO16903.1 - 4.9e-07 29.4 0.5 0.036 13.4 0.0 2.6 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 EDO16903.1 - 8.8e-07 28.8 0.0 0.031 14.0 0.0 2.9 2 1 0 2 2 2 2 IstB-like ATP binding protein AAA_18 PF13238.6 EDO16903.1 - 2.3e-06 28.2 0.0 0.074 13.6 0.0 2.8 2 0 0 2 2 2 2 AAA domain ABC_tran PF00005.27 EDO16903.1 - 3e-06 27.8 0.1 0.089 13.3 0.0 4.2 3 1 0 3 3 3 1 ABC transporter ATPase PF06745.13 EDO16903.1 - 3.4e-06 26.6 4.0 0.28 10.5 0.0 4.3 4 1 0 5 5 4 2 KaiC AAA_25 PF13481.6 EDO16903.1 - 6.1e-06 25.9 8.5 0.65 9.5 0.1 4.6 2 2 2 4 4 4 2 AAA domain AAA_7 PF12775.7 EDO16903.1 - 7.1e-06 25.7 0.1 0.067 12.7 0.0 2.7 2 1 0 2 2 2 2 P-loop containing dynein motor region AAA_24 PF13479.6 EDO16903.1 - 7.5e-06 25.8 0.0 0.086 12.6 0.0 3.0 2 1 0 2 2 2 2 AAA domain Sigma54_activat PF00158.26 EDO16903.1 - 1.3e-05 24.9 0.1 0.2 11.3 0.0 3.6 3 1 0 3 3 3 2 Sigma-54 interaction domain Parvo_NS1 PF01057.17 EDO16903.1 - 2.6e-05 23.4 0.1 0.13 11.3 0.0 2.5 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 PhoH PF02562.16 EDO16903.1 - 5.1e-05 22.8 0.5 0.18 11.2 0.1 2.4 2 0 0 2 2 2 2 PhoH-like protein AAA_28 PF13521.6 EDO16903.1 - 5.2e-05 23.6 0.0 0.5 10.6 0.0 2.7 2 0 0 2 2 2 2 AAA domain Bac_DnaA PF00308.18 EDO16903.1 - 5.2e-05 23.2 0.0 0.15 11.9 0.0 3.1 3 0 0 3 3 3 1 Bacterial dnaA protein AAA_3 PF07726.11 EDO16903.1 - 7.2e-05 22.7 0.0 0.48 10.3 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.6 EDO16903.1 - 7.6e-05 23.2 0.0 0.55 10.7 0.0 3.1 2 1 0 2 2 2 2 AAA domain DUF815 PF05673.13 EDO16903.1 - 8.6e-05 21.8 0.0 0.09 11.9 0.0 2.8 2 0 0 2 2 2 2 Protein of unknown function (DUF815) TsaE PF02367.17 EDO16903.1 - 0.00033 20.7 0.0 0.64 10.0 0.0 2.4 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE ResIII PF04851.15 EDO16903.1 - 0.00039 20.5 0.0 0.15 12.0 0.0 2.5 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DUF2075 PF09848.9 EDO16903.1 - 0.00056 19.3 0.0 0.87 8.8 0.0 2.4 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2075) NACHT PF05729.12 EDO16903.1 - 0.00087 19.2 0.2 2.2 8.2 0.0 3.6 4 0 0 4 4 4 1 NACHT domain AAA_11 PF13086.6 EDO16903.1 - 0.0016 18.3 5.6 0.97 9.2 0.0 3.1 2 1 0 2 2 2 1 AAA domain AAA_30 PF13604.6 EDO16903.1 - 0.0019 18.0 0.6 2.4 7.8 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.6 EDO16903.1 - 0.0032 17.8 0.4 3.2 8.1 0.0 3.1 2 1 1 3 3 2 1 AAA domain ATPase_2 PF01637.18 EDO16903.1 - 0.0084 16.1 3.3 2.6 7.9 0.1 3.9 3 2 1 4 4 3 1 ATPase domain predominantly from Archaea Mrr_cat PF04471.12 EDO16903.1 - 0.0094 16.0 0.0 7.2 6.7 0.0 2.9 2 0 0 2 2 2 0 Restriction endonuclease Zeta_toxin PF06414.12 EDO16903.1 - 0.012 14.9 0.0 6.5 6.0 0.0 3.1 3 0 0 3 3 2 0 Zeta toxin Sigma54_activ_2 PF14532.6 EDO16903.1 - 0.014 15.5 0.0 1.8 8.6 0.0 2.6 2 0 0 2 2 2 0 Sigma-54 interaction domain IPT PF01745.16 EDO16903.1 - 0.017 14.6 0.1 2.2 7.6 0.0 2.3 2 0 0 2 2 2 0 Isopentenyl transferase NTPase_1 PF03266.15 EDO16903.1 - 0.021 14.8 1.0 8 6.3 0.0 4.3 4 0 0 4 4 4 0 NTPase NB-ARC PF00931.22 EDO16903.1 - 0.022 13.9 0.0 4.7 6.3 0.0 2.5 2 0 0 2 2 2 0 NB-ARC domain Zot PF05707.12 EDO16903.1 - 0.04 13.5 0.1 2.7 7.6 0.0 3.2 2 2 0 2 2 2 0 Zonular occludens toxin (Zot) Cytidylate_kin PF02224.18 EDO16903.1 - 0.043 13.5 0.1 7.4 6.2 0.0 2.9 2 0 0 2 2 2 0 Cytidylate kinase KAP_NTPase PF07693.14 EDO16903.1 - 0.048 12.9 0.2 2.1 7.5 0.0 2.8 2 2 1 3 3 3 0 KAP family P-loop domain AAA_6 PF12774.7 EDO16903.1 - 0.08 11.9 0.2 5.5 5.9 0.0 2.7 3 0 0 3 3 2 0 Hydrolytic ATP binding site of dynein motor region UFD1 PF03152.14 EDO16903.1 - 0.1 12.1 0.0 0.27 10.7 0.0 1.7 1 1 0 1 1 1 0 Ubiquitin fusion degradation protein UFD1 eIF-1a PF01176.19 EDO16903.1 - 0.1 12.4 0.7 1 9.2 0.2 2.6 1 1 1 2 2 2 0 Translation initiation factor 1A / IF-1 HIT PF01230.23 EDO16904.1 - 1.2e-24 86.9 0.1 1.5e-24 86.5 0.1 1.1 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.8 EDO16904.1 - 8.6e-12 45.6 0.0 1.3e-11 45.0 0.0 1.3 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding CwfJ_C_1 PF04677.15 EDO16904.1 - 0.00081 19.2 0.0 0.0011 18.8 0.0 1.2 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 Aldo_ket_red PF00248.21 EDO16905.1 - 7.4e-43 146.8 0.0 1.8e-42 145.6 0.0 1.5 1 1 0 1 1 1 1 Aldo/keto reductase family UPF0029 PF01205.19 EDO16906.1 - 7e-31 106.7 0.0 1.4e-30 105.7 0.0 1.4 1 1 0 1 1 1 1 Uncharacterized protein family UPF0029 Branch PF02485.21 EDO16906.1 - 0.028 13.9 0.1 0.042 13.4 0.1 1.3 1 0 0 1 1 1 0 Core-2/I-Branching enzyme Pmp3 PF01679.17 EDO16907.1 - 1.2e-21 76.6 8.1 1.6e-21 76.2 8.1 1.2 1 0 0 1 1 1 1 Proteolipid membrane potential modulator Cyclin_N PF00134.23 EDO16908.1 - 1.9e-20 72.9 0.1 3.3e-20 72.1 0.1 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.11 EDO16908.1 - 1.3e-09 38.7 0.3 5.6e-09 36.6 0.0 1.9 2 0 0 2 2 2 1 Cyclin TruB_N PF01509.18 EDO16909.1 - 6.8e-42 143.3 1.5 1.6e-38 132.4 0.0 3.3 2 1 0 3 3 3 2 TruB family pseudouridylate synthase (N terminal domain) TruB_C_2 PF16198.5 EDO16909.1 - 0.0014 18.8 0.0 0.0042 17.2 0.0 1.9 1 0 0 1 1 1 1 tRNA pseudouridylate synthase B C-terminal domain PEPcase_2 PF14010.6 EDO16909.1 - 0.0073 14.9 1.4 0.0077 14.8 0.1 1.6 2 0 0 2 2 2 1 Phosphoenolpyruvate carboxylase DUF2540 PF10802.8 EDO16909.1 - 0.049 13.7 0.1 0.24 11.5 0.1 2.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2540) RabGAP-TBC PF00566.18 EDO16910.1 - 1.9e-40 138.8 2.6 9.6e-40 136.5 2.6 2.2 1 1 0 1 1 1 1 Rab-GTPase-TBC domain YlzJ PF14035.6 EDO16910.1 - 0.11 12.7 0.0 0.42 10.9 0.0 2.0 2 0 0 2 2 2 0 YlzJ-like protein DCB PF16213.5 EDO16911.1 - 7.1e-48 162.6 4.9 7.1e-48 162.6 4.9 3.3 3 0 0 3 3 3 1 Dimerisation and cyclophilin-binding domain of Mon2 Sec7_N PF12783.7 EDO16911.1 - 5.4e-31 107.6 4.7 5.4e-31 107.6 4.7 4.5 4 1 0 4 4 4 1 Guanine nucleotide exchange factor in Golgi transport N-terminal Mon2_C PF16206.5 EDO16911.1 - 1.2e-17 63.3 5.0 1.2e-13 50.2 0.1 3.9 4 0 0 4 4 4 3 C-terminal region of Mon2 protein Mrx7 PF10906.8 EDO16911.1 - 0.24 11.7 1.6 3.3 8.0 0.1 3.1 3 0 0 3 3 3 0 MIOREX complex component 7 RF-1 PF00472.20 EDO16912.1 - 1.6e-18 66.7 0.3 2.6e-18 66.0 0.3 1.3 1 0 0 1 1 1 1 RF-1 domain NTP_transf_2 PF01909.23 EDO16913.1 - 1.9e-18 66.5 0.1 1.9e-18 66.5 0.1 2.7 3 0 0 3 3 3 1 Nucleotidyltransferase domain PAP_assoc PF03828.19 EDO16913.1 - 1.1e-16 60.8 0.2 4.2e-16 58.9 0.2 2.1 1 0 0 1 1 1 1 Cid1 family poly A polymerase Polbeta PF18765.1 EDO16913.1 - 0.0038 17.3 0.0 0.0038 17.3 0.0 3.4 3 0 0 3 3 3 1 Polymerase beta, Nucleotidyltransferase GCR1_C PF12550.8 EDO16914.1 - 1.3e-23 83.1 0.4 2.5e-23 82.2 0.4 1.5 1 0 0 1 1 1 1 Transcriptional activator of glycolytic enzymes Redoxin PF08534.10 EDO16918.1 - 2.8e-29 101.7 0.0 3.1e-29 101.6 0.0 1.0 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 EDO16918.1 - 4e-07 30.0 0.0 4.7e-07 29.8 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family Ribosomal_L18 PF17135.4 EDO16919.1 - 1.7e-86 288.4 2.3 2e-86 288.2 2.3 1.0 1 0 0 1 1 1 1 Ribosomal protein 60S L18 and 50S L18e Ribosomal_L27A PF00828.19 EDO16919.1 - 0.006 17.3 0.4 0.015 16.0 0.4 1.8 1 1 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A Sigma_reg_N PF13800.6 EDO16919.1 - 0.12 12.7 0.6 0.23 11.8 0.6 1.3 1 0 0 1 1 1 0 Sigma factor regulator N-terminal Nudc_N PF14050.6 EDO16919.1 - 0.14 12.2 0.0 0.36 10.9 0.0 1.6 1 0 0 1 1 1 0 N-terminal conserved domain of Nudc. Ldh_1_C PF02866.18 EDO16920.1 - 3e-40 137.9 0.0 5e-40 137.2 0.0 1.4 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.23 EDO16920.1 - 2.2e-39 134.7 0.2 3.8e-39 134.0 0.2 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ribosomal_L23eN PF03939.13 EDO16921.1 - 1.4e-20 73.2 9.7 3.1e-20 72.1 9.7 1.6 1 0 0 1 1 1 1 Ribosomal protein L23, N-terminal domain Ribosomal_L23 PF00276.20 EDO16921.1 - 1.2e-17 64.0 1.5 1.2e-17 64.0 1.5 2.6 2 2 0 2 2 2 1 Ribosomal protein L23 UPF0220 PF05255.11 EDO16922.1 - 1.3e-72 242.8 1.8 1.5e-72 242.6 1.8 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0220) PrgI PF12666.7 EDO16922.1 - 0.62 10.8 2.9 2.1 9.1 0.1 2.2 2 0 0 2 2 2 0 PrgI family protein Caskin-Pro-rich PF16907.5 EDO16923.1 - 0.48 11.0 5.9 2 9.0 5.9 2.1 1 1 0 1 1 1 0 Proline rich region of Caskin proteins Glyco_hydro_72 PF03198.14 EDO16924.1 - 1.7e-132 441.5 2.4 2.2e-132 441.1 2.4 1.1 1 0 0 1 1 1 1 Glucanosyltransferase DNA_pol3_a_NII PF11490.8 EDO16924.1 - 0.039 13.9 0.6 0.1 12.5 0.1 1.9 2 0 0 2 2 2 0 DNA polymerase III polC-type N-terminus II EOS1 PF12326.8 EDO16925.1 - 7e-62 208.4 7.2 7e-62 208.4 7.2 3.1 2 1 1 3 3 3 2 N-glycosylation protein Zip PF02535.22 EDO16925.1 - 7.1 5.7 9.3 5.6 6.1 0.0 2.6 2 1 0 2 2 2 0 ZIP Zinc transporter MutL_C PF08676.11 EDO16926.1 - 6e-24 84.5 0.0 1.2e-23 83.5 0.0 1.5 1 0 0 1 1 1 1 MutL C terminal dimerisation domain DNA_mis_repair PF01119.19 EDO16926.1 - 6.1e-23 80.8 0.9 1.8e-22 79.2 0.1 2.1 2 0 0 2 2 2 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.6 EDO16926.1 - 3.7e-11 43.0 0.6 1.8e-10 40.8 0.2 2.3 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 EDO16926.1 - 2.3e-06 28.1 0.1 7.9e-06 26.4 0.1 2.0 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HORMA PF02301.18 EDO16927.1 - 8e-09 35.4 2.4 2.3e-08 33.9 2.4 1.8 1 1 0 1 1 1 1 HORMA domain Mito_carr PF00153.27 EDO16928.1 - 2.5e-62 206.8 5.7 7.1e-21 73.9 0.0 3.4 3 0 0 3 3 3 3 Mitochondrial carrier protein EF-hand_7 PF13499.6 EDO16928.1 - 2.7e-13 50.2 5.6 3.6e-09 36.9 1.2 3.2 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 EDO16928.1 - 3.1e-13 48.5 3.7 0.00028 20.6 0.1 4.7 4 0 0 4 4 4 3 EF-hand domain EF-hand_1 PF00036.32 EDO16928.1 - 4e-11 41.6 9.1 8.5e-05 21.8 0.4 4.6 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.6 EDO16928.1 - 2.9e-07 30.2 5.9 0.043 13.7 0.2 3.6 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 EDO16928.1 - 1.4e-06 27.5 2.7 9e-05 21.8 0.7 3.9 4 0 0 4 4 4 2 EF hand SPARC_Ca_bdg PF10591.9 EDO16928.1 - 0.022 15.0 11.5 0.76 10.1 0.5 3.3 1 1 2 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region LTXXQ PF07813.12 EDO16928.1 - 0.1 13.3 0.0 0.17 12.6 0.0 1.3 1 0 0 1 1 1 0 LTXXQ motif family protein 4HBT PF03061.22 EDO16929.1 - 0.00055 20.2 0.1 1.7 9.1 0.0 2.4 2 0 0 2 2 2 2 Thioesterase superfamily SKG6 PF08693.10 EDO16930.1 - 8.2e-12 44.3 0.7 2e-11 43.1 0.7 1.6 1 0 0 1 1 1 1 Transmembrane alpha-helix domain He_PIG PF05345.12 EDO16930.1 - 1.3e-10 41.2 11.2 6.4e-05 23.1 0.0 4.4 5 0 0 5 5 5 2 Putative Ig domain Mid2 PF04478.12 EDO16930.1 - 0.00021 21.1 1.1 0.00051 19.9 0.5 1.9 1 1 0 1 1 1 1 Mid2 like cell wall stress sensor EVI2A PF05399.11 EDO16930.1 - 0.00034 20.3 2.4 0.00087 18.9 2.4 1.7 1 0 0 1 1 1 1 Ectropic viral integration site 2A protein (EVI2A) DUF4448 PF14610.6 EDO16930.1 - 0.0043 16.9 0.1 0.011 15.5 0.1 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF4448) TMEM154 PF15102.6 EDO16930.1 - 0.014 15.3 1.8 0.014 15.3 1.8 2.1 2 0 0 2 2 2 0 TMEM154 protein family Adeno_E3_CR2 PF02439.15 EDO16930.1 - 0.02 14.6 0.3 0.033 14.0 0.3 1.3 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 RIFIN PF02009.16 EDO16930.1 - 0.067 13.1 0.0 0.11 12.4 0.0 1.3 1 0 0 1 1 1 0 Rifin EssA PF10661.9 EDO16930.1 - 0.12 12.2 4.8 0.43 10.4 0.5 2.7 2 0 0 2 2 2 0 WXG100 protein secretion system (Wss), protein EssA MGC-24 PF05283.11 EDO16930.1 - 0.14 12.6 6.6 0.39 11.2 6.6 1.8 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin Herpes_pp85 PF04637.12 EDO16930.1 - 0.57 8.5 11.3 0.85 8.0 11.3 1.2 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) Cpn60_TCP1 PF00118.24 EDO16931.1 - 1.1e-148 495.9 10.1 1.3e-148 495.7 10.1 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Dak2 PF02734.17 EDO16931.1 - 0.033 14.1 0.8 3.7 7.4 0.1 2.4 2 0 0 2 2 2 0 DAK2 domain CRM1_repeat PF18777.1 EDO16931.1 - 0.15 11.6 0.0 0.34 10.5 0.0 1.6 1 0 0 1 1 1 0 Chromosome region maintenance or exportin repeat Snapin_Pallidin PF14712.6 EDO16932.1 - 4.4e-06 27.0 2.2 5.5e-06 26.7 2.2 1.1 1 0 0 1 1 1 1 Snapin/Pallidin Fzo_mitofusin PF04799.13 EDO16932.1 - 0.018 14.6 0.5 0.023 14.2 0.5 1.2 1 0 0 1 1 1 0 fzo-like conserved region DASH_Dam1 PF08653.10 EDO16932.1 - 0.36 10.6 1.4 10 6.0 0.0 2.6 1 1 1 2 2 2 0 DASH complex subunit Dam1 DFRP_C PF16543.5 EDO16933.1 - 7.1e-25 87.3 6.7 7.1e-25 87.3 6.7 3.5 4 0 0 4 4 4 1 DRG Family Regulatory Proteins, Tma46 Torus PF16131.5 EDO16933.1 - 4.1e-05 24.2 10.6 0.00075 20.2 1.3 3.4 2 1 1 3 3 3 2 Torus domain zf-CCCH_4 PF18044.1 EDO16933.1 - 0.00054 19.7 6.5 0.063 13.1 0.5 3.4 3 0 0 3 3 3 2 CCCH-type zinc finger zf_CCCH_4 PF18345.1 EDO16933.1 - 0.00073 19.5 2.7 0.00073 19.5 2.7 3.1 3 0 0 3 3 3 2 Zinc finger domain zf-CCCH PF00642.24 EDO16933.1 - 0.00096 19.0 0.1 0.00096 19.0 0.1 2.6 3 0 0 3 3 3 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_3 PF15663.5 EDO16933.1 - 0.17 12.1 3.3 2.4 8.4 0.3 2.7 1 1 1 2 2 2 0 Zinc-finger containing family zf-CCCH_2 PF14608.6 EDO16933.1 - 0.57 10.7 13.0 1.2 9.7 2.5 2.8 2 1 0 2 2 2 0 RNA-binding, Nab2-type zinc finger DUF2183 PF09949.9 EDO16934.1 - 7.9e-31 106.3 2.2 1.5e-30 105.5 0.1 2.3 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2183) LNS2 PF08235.13 EDO16934.1 - 0.0088 15.5 0.0 0.015 14.7 0.0 1.3 1 0 0 1 1 1 1 LNS2 (Lipin/Ned1/Smp2) Mem_trans PF03547.18 EDO16935.1 - 1.3e-29 102.8 0.0 8.1e-29 100.2 0.0 1.9 1 1 0 1 1 1 1 Membrane transport protein AMP-binding PF00501.28 EDO16936.1 - 8.2e-42 143.3 0.0 6.5e-18 64.5 0.0 5.1 5 0 0 5 5 5 5 AMP-binding enzyme DMAP_binding PF06464.11 EDO16936.1 - 2.9e-16 60.3 1.5 2.9e-16 60.3 1.5 3.5 2 1 1 3 3 3 1 DMAP1-binding Domain Arf PF00025.21 EDO16937.1 - 1.1e-71 239.9 0.2 1.3e-71 239.7 0.2 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EDO16937.1 - 5e-16 59.0 0.1 7e-16 58.5 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EDO16937.1 - 3.7e-14 52.6 0.0 4.5e-14 52.4 0.0 1.1 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 EDO16937.1 - 4e-14 52.4 0.0 5e-14 52.1 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 EDO16937.1 - 2.4e-13 50.0 1.8 7.1e-09 35.3 0.2 2.2 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.12 EDO16937.1 - 4.6e-10 39.3 0.0 5.6e-10 39.0 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EDO16937.1 - 4.9e-06 26.6 0.0 7.6e-06 26.0 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.18 EDO16937.1 - 0.11 11.7 0.1 0.23 10.8 0.1 1.4 1 0 0 1 1 1 0 6-phosphofructo-2-kinase Rib_5-P_isom_A PF06026.14 EDO16938.1 - 1.3e-57 194.1 0.0 1.7e-57 193.8 0.0 1.1 1 0 0 1 1 1 1 Ribose 5-phosphate isomerase A (phosphoriboisomerase A) DeoRC PF00455.22 EDO16938.1 - 0.003 17.5 0.0 1.6 8.6 0.0 2.4 3 0 0 3 3 3 2 DeoR C terminal sensor domain Gal_mutarotas_2 PF13802.6 EDO16938.1 - 0.012 15.9 0.1 0.027 14.8 0.0 1.6 2 0 0 2 2 2 0 Galactose mutarotase-like Ribosomal_S7e PF01251.18 EDO16939.1 - 2.8e-81 271.7 1.9 3.1e-81 271.5 1.9 1.0 1 0 0 1 1 1 1 Ribosomal protein S7e DUF692 PF05114.13 EDO16939.1 - 0.085 12.0 0.0 0.17 11.1 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF692) DUF2345 PF10106.9 EDO16939.1 - 0.086 12.7 0.0 0.49 10.2 0.0 2.0 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2345) Glyco_transf_15 PF01793.16 EDO16941.1 - 1.5e-126 422.0 15.2 1.8e-126 421.8 15.2 1.0 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase Glyco_transf_15 PF01793.16 EDO16942.1 - 8.2e-126 419.6 16.9 1.1e-125 419.3 16.9 1.0 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase CKS PF01111.19 EDO16942.1 - 0.098 12.9 1.0 0.36 11.1 1.0 1.9 1 0 0 1 1 1 0 Cyclin-dependent kinase regulatory subunit Mito_carr PF00153.27 EDO16943.1 - 5.7e-52 173.6 5.5 1.1e-19 70.2 0.1 3.5 3 1 0 3 3 3 3 Mitochondrial carrier protein Pentaxin PF00354.17 EDO16943.1 - 0.12 12.1 0.0 0.2 11.3 0.0 1.2 1 0 0 1 1 1 0 Pentaxin family DUF3090 PF11290.8 EDO16943.1 - 0.19 11.5 0.0 0.52 10.1 0.0 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3090) GIT_SHD PF08518.11 EDO16944.1 - 3.3e-22 77.8 5.7 1.5e-11 43.7 0.7 2.7 2 0 0 2 2 2 2 Spa2 homology domain (SHD) of GIT HSP70 PF00012.20 EDO16945.1 - 5.2e-261 867.1 10.7 5.9e-261 866.9 10.7 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EDO16945.1 - 3.9e-16 58.8 0.0 6e-15 54.9 0.0 2.2 2 0 0 2 2 2 1 MreB/Mbl protein DDR PF08841.10 EDO16945.1 - 0.0019 17.3 0.4 0.014 14.4 0.2 2.2 2 0 0 2 2 2 1 Diol dehydratase reactivase ATPase-like domain FGGY_C PF02782.16 EDO16945.1 - 0.003 17.3 0.0 0.012 15.3 0.0 2.0 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain TMCO5 PF14992.6 EDO16945.1 - 1.7 8.1 6.7 3 7.4 6.7 1.3 1 0 0 1 1 1 0 TMCO5 family AMPK1_CBM PF16561.5 EDO16946.1 - 4.3e-13 49.3 0.4 8.3e-13 48.4 0.4 1.4 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase RRM_1 PF00076.22 EDO16947.1 - 4.4e-27 93.7 0.4 7e-19 67.4 0.0 3.6 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EDO16947.1 - 0.00078 19.4 0.0 0.0016 18.4 0.0 1.5 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif FAM150 PF15129.6 EDO16947.1 - 0.0013 18.9 1.0 0.0041 17.3 0.8 2.0 1 1 0 1 1 1 1 FAM150 family RRM_7 PF16367.5 EDO16947.1 - 0.011 15.8 0.0 1.4 9.1 0.0 3.0 2 1 0 2 2 2 0 RNA recognition motif RPA43_OB PF17875.1 EDO16947.1 - 0.11 13.1 3.3 0.32 11.6 3.3 1.7 1 0 0 1 1 1 0 RPA43 OB domain in RNA Pol I Seryl_tRNA_N PF02403.22 EDO16947.1 - 3.2 8.0 14.1 0.2 11.9 7.9 2.3 2 1 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Syndecan PF01034.20 EDO16948.1 - 0.0013 18.6 0.0 0.0028 17.5 0.0 1.5 1 0 0 1 1 1 1 Syndecan domain Glycophorin_A PF01102.18 EDO16948.1 - 0.0033 17.7 0.0 0.0079 16.4 0.0 1.6 1 0 0 1 1 1 1 Glycophorin A PTP_tm PF18861.1 EDO16948.1 - 0.048 13.7 0.0 0.092 12.7 0.0 1.5 1 0 0 1 1 1 0 Transmembrane domain of protein tyrosine phosphatase, receptor type J PIRT PF15099.6 EDO16948.1 - 0.048 13.2 0.0 0.11 12.1 0.0 1.6 1 0 0 1 1 1 0 Phosphoinositide-interacting protein family CCSMST1 PF15013.6 EDO16948.1 - 0.058 13.6 0.0 0.14 12.4 0.0 1.7 1 0 0 1 1 1 0 CCSMST1 family Orf78 PF06024.12 EDO16948.1 - 0.28 11.5 1.7 0.41 11.0 0.0 2.1 2 1 0 2 2 2 0 Orf78 (ac78) Ras PF00071.22 EDO16949.1 - 7.3e-46 155.7 1.4 1.2e-45 155.0 0.0 1.8 2 0 0 2 2 2 1 Ras family Roc PF08477.13 EDO16949.1 - 8.9e-22 77.6 0.0 4.2e-21 75.4 0.0 2.1 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EDO16949.1 - 5e-05 22.8 0.0 8.5e-05 22.1 0.0 1.4 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EDO16949.1 - 0.00053 19.6 0.1 0.003 17.1 0.0 2.3 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EDO16949.1 - 0.0034 17.5 0.0 0.0056 16.8 0.0 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EDO16949.1 - 0.048 13.6 2.3 0.52 10.2 0.3 2.8 1 1 1 2 2 2 0 RsgA GTPase AAA_16 PF13191.6 EDO16949.1 - 0.17 12.3 0.0 0.25 11.7 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain RRM_1 PF00076.22 EDO16950.1 - 1.1e-05 25.1 0.0 2.1e-05 24.2 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EDO16950.1 - 0.02 15.0 0.0 0.059 13.5 0.0 1.7 1 1 0 1 1 1 0 RNA recognition motif Pkinase PF00069.25 EDO16951.1 - 3.3e-50 170.9 0.2 8e-50 169.6 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO16951.1 - 1.6e-24 86.6 0.0 2.2e-24 86.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EDO16951.1 - 0.00063 18.8 0.3 0.0014 17.6 0.2 1.5 1 1 0 1 1 1 1 Haspin like kinase domain FTA2 PF13095.6 EDO16951.1 - 0.0016 18.1 1.0 1.4 8.5 0.1 2.2 1 1 1 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 EDO16951.1 - 0.025 14.5 0.1 0.052 13.5 0.1 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kinase-like PF14531.6 EDO16951.1 - 0.1 11.9 0.0 0.19 11.0 0.0 1.4 1 0 0 1 1 1 0 Kinase-like ELFV_dehydrog PF00208.21 EDO16952.1 - 1.6e-60 204.8 0.0 3.3e-60 203.8 0.0 1.5 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Bac_GDH PF05088.12 EDO16952.1 - 1.8e-13 49.0 1.8 9.5e-10 36.7 0.3 2.1 2 0 0 2 2 2 2 Bacterial NAD-glutamate dehydrogenase ELFV_dehydrog_N PF02812.18 EDO16952.1 - 0.023 14.6 0.0 0.053 13.4 0.0 1.6 1 0 0 1 1 1 0 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain JAB PF01398.21 EDO16953.1 - 7.7e-27 93.6 0.3 1.7e-26 92.5 0.3 1.6 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Prok-JAB PF14464.6 EDO16953.1 - 7.3e-05 22.5 0.0 0.00013 21.7 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain Arm PF00514.23 EDO16955.1 - 1.1e-87 285.7 14.5 1e-12 47.6 0.2 8.5 8 0 0 8 8 8 8 Armadillo/beta-catenin-like repeat IBB PF01749.20 EDO16955.1 - 5.8e-29 100.4 3.6 2e-28 98.7 3.6 2.0 1 0 0 1 1 1 1 Importin beta binding domain Arm_3 PF16186.5 EDO16955.1 - 1e-20 73.0 2.9 7.1e-20 70.3 3.8 2.0 2 0 0 2 2 2 1 Atypical Arm repeat HEAT_EZ PF13513.6 EDO16955.1 - 1.8e-19 69.8 0.2 8.2e-05 23.0 0.0 6.7 4 2 3 7 7 7 6 HEAT-like repeat HEAT_2 PF13646.6 EDO16955.1 - 1.8e-14 53.8 0.4 0.0031 17.9 0.0 5.3 2 1 3 5 5 5 4 HEAT repeats HEAT PF02985.22 EDO16955.1 - 1.8e-10 40.1 0.0 2.3 8.7 0.0 6.8 7 0 0 7 7 7 2 HEAT repeat Arm_2 PF04826.13 EDO16955.1 - 2.3e-06 27.3 2.2 0.31 10.5 0.0 4.5 3 2 1 4 4 4 2 Armadillo-like V-ATPase_H_C PF11698.8 EDO16955.1 - 2.5e-06 27.6 0.6 0.19 11.9 0.0 4.4 3 2 2 5 5 5 3 V-ATPase subunit H Adaptin_N PF01602.20 EDO16955.1 - 1.5e-05 23.7 0.1 5e-05 22.0 0.1 2.0 1 1 0 1 1 1 1 Adaptin N terminal region RICTOR_V PF14668.6 EDO16955.1 - 0.00023 21.3 4.9 2.8 8.2 0.0 5.4 6 1 0 6 6 5 2 Rapamycin-insensitive companion of mTOR, domain 5 Atx10homo_assoc PF09759.9 EDO16955.1 - 0.00086 19.3 0.2 2.5 8.2 0.0 4.4 4 1 0 4 4 4 1 Spinocerebellar ataxia type 10 protein domain Cnd1 PF12717.7 EDO16955.1 - 0.017 15.2 1.3 0.75 9.8 0.0 3.0 2 1 0 3 3 3 0 non-SMC mitotic condensation complex subunit 1 MARVEL PF01284.23 EDO16956.1 - 1.1e-24 87.1 5.1 1.5e-24 86.7 5.1 1.1 1 0 0 1 1 1 1 Membrane-associating domain DUF2755 PF10954.8 EDO16956.1 - 0.049 13.6 0.6 0.32 10.9 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2755) GATase_4 PF13230.6 EDO16957.1 - 4.8e-15 55.2 0.0 2.6e-13 49.5 0.0 2.1 2 0 0 2 2 2 2 Glutamine amidotransferases class-II GATase_6 PF13522.6 EDO16957.1 - 1e-10 41.9 0.0 1.9e-10 41.1 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.6 EDO16957.1 - 0.023 14.6 0.0 0.1 12.5 0.0 1.9 2 0 0 2 2 2 0 Glutamine amidotransferase domain Tyr_Deacylase PF02580.16 EDO16958.1 - 1e-50 172.0 0.0 1.1e-50 171.8 0.0 1.0 1 0 0 1 1 1 1 D-Tyr-tRNA(Tyr) deacylase DUF2167 PF09935.9 EDO16958.1 - 0.013 14.7 0.0 0.016 14.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2167) PolyA_pol PF01743.20 EDO16959.1 - 0.037 14.5 2.5 0.17 12.3 0.4 2.8 2 0 0 2 2 2 0 Poly A polymerase head domain COX6B PF02297.17 EDO16960.1 - 1.1e-20 73.6 4.7 1.3e-20 73.4 4.7 1.1 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb CX9C PF16860.5 EDO16960.1 - 0.031 14.3 1.4 0.052 13.6 1.4 1.3 1 0 0 1 1 1 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, APOBEC_C PF05240.14 EDO16960.1 - 0.068 13.1 0.3 0.087 12.8 0.3 1.3 1 0 0 1 1 1 0 APOBEC-like C-terminal domain RIC1 PF07064.13 EDO16961.1 - 1.3e-21 77.2 0.4 3.4e-21 75.8 0.4 1.7 1 1 0 1 1 1 1 RIC1 CAF1C_H4-bd PF12265.8 EDO16962.1 - 6.6e-16 58.3 0.2 2.4e-15 56.5 0.1 2.1 2 0 0 2 2 2 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 EDO16962.1 - 1.2e-11 45.0 5.4 0.0008 20.2 0.0 5.4 6 0 0 6 6 6 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDO16962.1 - 1.4e-06 28.5 2.0 0.076 13.3 0.1 3.3 2 1 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain NFACT-R_1 PF05670.13 EDO16963.1 - 1.6e-32 112.4 0.2 3.8e-32 111.2 0.0 1.6 2 0 0 2 2 2 1 NFACT protein RNA binding domain Trp_dioxygenase PF03301.13 EDO16963.1 - 0.41 9.9 5.4 0.62 9.3 2.0 2.0 2 0 0 2 2 2 0 Tryptophan 2,3-dioxygenase DUF1682 PF07946.14 EDO16963.1 - 1.8 7.7 10.0 2.4 7.3 10.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) VSP PF03302.13 EDO16964.1 - 0.57 9.0 1.8 0.77 8.5 1.8 1.1 1 0 0 1 1 1 0 Giardia variant-specific surface protein SRP1_TIP1 PF00660.17 EDO16965.1 - 1.2e-11 44.6 1.6 2.2e-11 43.7 0.8 1.9 1 1 0 1 1 1 1 Seripauperin and TIP1 family SprA-related PF12118.8 EDO16965.1 - 7.1 5.7 14.7 13 4.8 14.7 1.3 1 0 0 1 1 1 0 SprA-related family CLTH PF10607.9 EDO16967.1 - 1.9e-27 96.0 12.8 1.9e-27 96.0 12.8 2.8 2 1 1 3 3 3 1 CTLH/CRA C-terminal to LisH motif domain GATA PF00320.27 EDO16968.1 - 2.1e-16 59.2 2.6 3.6e-16 58.5 2.6 1.4 1 0 0 1 1 1 1 GATA zinc finger T4_baseplate PF12322.8 EDO16968.1 - 0.047 13.2 0.8 0.43 10.0 0.1 2.2 2 0 0 2 2 2 0 T4 bacteriophage base plate protein Arf PF00025.21 EDO16969.1 - 9.1e-33 113.2 0.0 1.2e-32 112.8 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EDO16969.1 - 6.2e-09 36.1 0.0 9.9e-09 35.4 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EDO16969.1 - 1.6e-08 34.3 0.0 2.5e-08 33.7 0.0 1.4 1 1 0 1 1 1 1 Ras family G-alpha PF00503.20 EDO16969.1 - 2e-07 30.5 0.0 0.0074 15.5 0.0 2.1 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.12 EDO16969.1 - 2.6e-06 26.9 0.0 3.8e-06 26.4 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EDO16969.1 - 7.2e-05 22.8 0.1 0.00011 22.2 0.1 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EDO16969.1 - 0.00048 19.7 0.0 0.052 13.1 0.0 2.2 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 EDO16969.1 - 0.0024 17.3 0.0 0.0033 16.9 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit FeoB_N PF02421.18 EDO16969.1 - 0.028 13.9 0.1 0.67 9.5 0.0 2.3 2 0 0 2 2 2 0 Ferrous iron transport protein B Ldh_1_N PF00056.23 EDO16970.1 - 3.4e-40 137.4 0.2 6.9e-40 136.4 0.1 1.6 2 0 0 2 2 2 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.18 EDO16970.1 - 3.1e-32 111.8 0.0 7.8e-32 110.5 0.0 1.7 1 1 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain 3Beta_HSD PF01073.19 EDO16970.1 - 0.0016 17.5 0.0 0.0041 16.2 0.0 1.6 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family Semialdhyde_dh PF01118.24 EDO16970.1 - 0.054 13.9 0.0 0.13 12.7 0.0 1.7 1 1 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain Pkinase PF00069.25 EDO16971.1 - 1.5e-64 217.9 0.1 2e-64 217.5 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO16971.1 - 7.4e-26 91.0 0.0 1.1e-25 90.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EDO16971.1 - 0.038 13.9 0.1 0.23 11.3 0.2 1.8 1 1 0 2 2 2 0 Phosphotransferase enzyme family RICTOR_M PF14666.6 EDO16971.1 - 0.4 10.5 3.6 1.5 8.7 0.8 2.8 2 2 0 2 2 2 0 Rapamycin-insensitive companion of mTOR, middle domain UPF0370 PF13980.6 EDO16972.1 - 0.046 13.8 1.2 6.6 6.9 0.0 3.0 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0370) zf-C3HC4_3 PF13920.6 EDO16972.1 - 0.055 13.3 7.8 0.2 11.5 4.6 2.2 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) UIM PF02809.20 EDO16972.1 - 0.062 13.2 2.6 0.081 12.9 0.7 2.3 2 0 0 2 2 2 0 Ubiquitin interaction motif Ribosomal_L13e PF01294.18 EDO16973.1 - 7.2e-68 228.0 4.4 1.2e-67 227.3 4.4 1.3 1 0 0 1 1 1 1 Ribosomal protein L13e Ribosomal_S9 PF00380.19 EDO16974.1 - 1.8e-32 112.4 0.1 2e-32 112.3 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S9/S16 DEAD PF00270.29 EDO16975.1 - 1.1e-34 119.7 0.2 2e-34 118.9 0.0 1.5 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDO16975.1 - 9.7e-28 96.7 0.1 2.4e-25 89.0 0.3 2.5 2 0 0 2 2 2 2 Helicase conserved C-terminal domain ResIII PF04851.15 EDO16975.1 - 2.9e-08 33.9 0.0 6.6e-08 32.7 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HTH_psq PF05225.16 EDO16976.1 - 0.003 17.2 0.0 0.0072 16.0 0.0 1.6 1 0 0 1 1 1 1 helix-turn-helix, Psq domain PH_BEACH PF14844.6 EDO16976.1 - 0.067 13.3 0.3 10 6.3 0.0 2.9 2 0 0 2 2 2 0 PH domain associated with Beige/BEACH HTH_7 PF02796.15 EDO16976.1 - 0.13 12.3 0.0 0.55 10.4 0.0 2.0 2 0 0 2 2 2 0 Helix-turn-helix domain of resolvase HTH_Tnp_Tc5 PF03221.16 EDO16976.1 - 0.19 11.8 2.5 0.5 10.4 0.4 2.8 3 1 0 3 3 3 0 Tc5 transposase DNA-binding domain NUC153 PF08159.12 EDO16977.1 - 7.8e-12 44.8 3.7 1.7e-11 43.7 3.7 1.6 1 0 0 1 1 1 1 NUC153 domain ANAPC4_WD40 PF12894.7 EDO16977.1 - 0.035 14.4 0.0 1.1 9.7 0.0 2.7 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EDO16977.1 - 0.061 14.2 3.2 39 5.4 0.1 4.1 4 0 0 4 4 4 0 WD domain, G-beta repeat LptF_LptG PF03739.14 EDO16977.1 - 1.7 7.4 6.5 2.9 6.6 6.5 1.3 1 0 0 1 1 1 0 Lipopolysaccharide export system permease LptF/LptG Isochorismatase PF00857.20 EDO16978.1 - 1.2e-20 74.4 0.0 1.7e-20 73.9 0.0 1.1 1 0 0 1 1 1 1 Isochorismatase family tRNA_bind PF01588.20 EDO16979.1 - 9.7e-20 70.5 0.2 1.5e-19 69.9 0.2 1.2 1 0 0 1 1 1 1 Putative tRNA binding domain PITH PF06201.13 EDO16980.1 - 2.1e-36 125.5 1.1 2.5e-36 125.2 1.1 1.1 1 0 0 1 1 1 1 PITH domain CSTF2_hinge PF14327.6 EDO16981.1 - 1.8e-23 82.8 0.9 1.8e-23 82.8 0.9 2.9 3 0 0 3 3 3 1 Hinge domain of cleavage stimulation factor subunit 2 CSTF_C PF14304.6 EDO16981.1 - 4.3e-07 29.4 5.0 4.3e-07 29.4 5.0 3.0 3 0 0 3 3 3 1 Transcription termination and cleavage factor C-terminal PEMT PF04191.13 EDO16982.1 - 1.2e-61 205.6 9.0 8.7e-36 122.5 1.7 2.8 2 0 0 2 2 2 2 Phospholipid methyltransferase HECW_N PF16562.5 EDO16982.1 - 0.013 15.3 0.1 0.028 14.2 0.1 1.5 1 0 0 1 1 1 0 N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2 AAA PF00004.29 EDO16984.1 - 3.1e-43 147.3 0.0 6.1e-43 146.4 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EDO16984.1 - 3e-14 52.5 0.4 9e-14 51.0 0.0 2.1 3 0 0 3 3 1 1 AAA+ lid domain Prot_ATP_ID_OB PF16450.5 EDO16984.1 - 1.4e-08 34.6 1.4 3.1e-08 33.4 1.4 1.7 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_2 PF07724.14 EDO16984.1 - 8.3e-07 29.3 0.0 2e-06 28.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 EDO16984.1 - 1.9e-06 28.0 0.0 1.2e-05 25.3 0.0 2.4 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EDO16984.1 - 2.2e-05 24.9 0.0 0.00031 21.2 0.0 2.4 1 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 EDO16984.1 - 3.3e-05 24.2 0.2 0.0059 16.9 0.2 2.5 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.12 EDO16984.1 - 9.8e-05 22.1 0.0 0.00022 21.0 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 EDO16984.1 - 0.0012 19.4 0.3 0.022 15.3 0.0 2.8 3 1 0 3 3 3 1 AAA domain IstB_IS21 PF01695.17 EDO16984.1 - 0.0014 18.4 0.0 0.0027 17.4 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_33 PF13671.6 EDO16984.1 - 0.0022 18.1 0.0 0.0049 17.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.6 EDO16984.1 - 0.0041 17.4 0.0 0.0086 16.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_3 PF07726.11 EDO16984.1 - 0.0066 16.3 0.0 0.019 14.8 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.21 EDO16984.1 - 0.01 15.3 0.2 0.028 13.8 0.0 1.7 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI TIP49 PF06068.13 EDO16984.1 - 0.011 14.9 0.0 0.028 13.6 0.0 1.6 1 1 0 1 1 1 0 TIP49 P-loop domain AAA_14 PF13173.6 EDO16984.1 - 0.016 15.2 0.0 0.036 14.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 EDO16984.1 - 0.017 15.1 0.0 0.039 14.0 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE DUF2072 PF09845.9 EDO16984.1 - 0.017 15.3 0.4 0.035 14.4 0.4 1.5 1 0 0 1 1 1 0 Zn-ribbon containing protein PhoH PF02562.16 EDO16984.1 - 0.019 14.5 0.0 0.076 12.5 0.0 1.9 2 0 0 2 2 2 0 PhoH-like protein AAA_24 PF13479.6 EDO16984.1 - 0.028 14.1 0.0 0.19 11.4 0.0 2.1 2 0 0 2 2 2 0 AAA domain Sigma54_activat PF00158.26 EDO16984.1 - 0.032 13.9 0.0 0.17 11.6 0.0 2.2 3 0 0 3 3 3 0 Sigma-54 interaction domain RNA_helicase PF00910.22 EDO16984.1 - 0.038 14.4 0.0 0.092 13.1 0.0 1.7 1 1 0 1 1 1 0 RNA helicase AAA_19 PF13245.6 EDO16984.1 - 0.043 14.2 0.1 0.65 10.3 0.1 2.3 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 EDO16984.1 - 0.047 13.3 0.0 0.14 11.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 EDO16984.1 - 0.085 12.4 0.0 0.15 11.6 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region DUF815 PF05673.13 EDO16984.1 - 0.086 12.0 0.0 0.18 10.9 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Zeta_toxin PF06414.12 EDO16984.1 - 0.1 11.9 0.0 0.25 10.6 0.0 1.7 1 0 0 1 1 1 0 Zeta toxin Parvo_NS1 PF01057.17 EDO16984.1 - 0.11 11.6 0.0 0.18 10.9 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_30 PF13604.6 EDO16984.1 - 0.13 12.0 0.0 0.33 10.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 EDO16984.1 - 0.17 11.8 0.0 0.43 10.5 0.0 1.7 2 0 0 2 2 2 0 NACHT domain ATG16 PF08614.11 EDO16984.1 - 0.34 11.1 2.8 0.56 10.4 2.8 1.3 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) MIF4G PF02854.19 EDO16985.1 - 2e-48 164.9 0.2 3.6e-48 164.0 0.2 1.5 1 0 0 1 1 1 1 MIF4G domain eIF_4G1 PF12152.8 EDO16985.1 - 1e-25 89.7 0.7 3.3e-25 88.0 0.7 2.0 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 4G1 Cys_Met_Meta_PP PF01053.20 EDO16986.1 - 4e-146 486.4 0.0 4.5e-146 486.3 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 EDO16986.1 - 8.3e-12 44.7 0.1 1.2e-11 44.2 0.1 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.21 EDO16986.1 - 2.3e-10 40.2 0.0 3.5e-10 39.6 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 EDO16986.1 - 1.1e-09 38.1 0.0 2.2e-09 37.1 0.0 1.4 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Beta_elim_lyase PF01212.21 EDO16986.1 - 4.2e-05 23.0 0.0 7.8e-05 22.1 0.0 1.4 1 0 0 1 1 1 1 Beta-eliminating lyase Asparaginase_C PF17763.1 EDO16986.1 - 0.0017 18.6 0.0 0.0041 17.3 0.0 1.6 1 0 0 1 1 1 1 Glutaminase/Asparaginase C-terminal domain Met_gamma_lyase PF06838.11 EDO16986.1 - 0.011 14.2 0.5 0.021 13.4 0.5 1.3 1 1 0 1 1 1 0 Methionine gamma-lyase GDC-P PF02347.16 EDO16986.1 - 0.11 11.4 0.0 0.16 10.7 0.0 1.2 1 0 0 1 1 1 0 Glycine cleavage system P-protein ABC_membrane PF00664.23 EDO16987.1 - 5.4e-59 200.1 57.6 5.2e-31 108.3 14.4 3.2 3 0 0 3 3 3 2 ABC transporter transmembrane region ABC_tran PF00005.27 EDO16987.1 - 1e-51 175.0 0.3 2.5e-29 102.5 0.3 2.7 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EDO16987.1 - 2.6e-07 30.3 15.8 0.00072 19.1 0.8 4.3 3 2 0 3 3 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EDO16987.1 - 3.2e-07 30.0 0.1 0.016 14.9 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_21 PF13304.6 EDO16987.1 - 4.1e-07 30.1 3.4 0.039 13.8 0.0 4.1 3 1 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system MMR_HSR1 PF01926.23 EDO16987.1 - 6.3e-06 26.3 0.4 0.075 13.1 0.1 3.0 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_22 PF13401.6 EDO16987.1 - 1e-05 25.8 1.5 0.019 15.2 0.0 3.1 2 1 0 2 2 2 2 AAA domain AAA_16 PF13191.6 EDO16987.1 - 0.0002 21.8 0.2 0.77 10.1 0.0 2.5 2 0 0 2 2 2 2 AAA ATPase domain T2SSE PF00437.20 EDO16987.1 - 0.00021 20.4 0.2 0.12 11.5 0.0 2.4 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_23 PF13476.6 EDO16987.1 - 0.0011 19.5 16.2 0.13 12.8 7.9 3.5 2 2 0 2 2 2 2 AAA domain NB-ARC PF00931.22 EDO16987.1 - 0.0011 18.2 1.4 1.7 7.8 0.0 3.3 4 0 0 4 4 3 2 NB-ARC domain AAA_30 PF13604.6 EDO16987.1 - 0.0015 18.3 0.8 0.56 9.9 0.0 2.6 3 0 0 3 3 2 1 AAA domain RsgA_GTPase PF03193.16 EDO16987.1 - 0.0025 17.7 0.0 4 7.3 0.0 2.8 2 0 0 2 2 2 2 RsgA GTPase TsaE PF02367.17 EDO16987.1 - 0.004 17.2 0.1 0.65 10.0 0.0 2.5 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE TrwB_AAD_bind PF10412.9 EDO16987.1 - 0.0068 15.4 0.1 1.6 7.6 0.0 2.2 2 0 0 2 2 2 1 Type IV secretion-system coupling protein DNA-binding domain CbiA PF01656.23 EDO16987.1 - 0.013 15.6 1.4 1.4 9.0 0.0 3.7 4 0 0 4 4 4 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_18 PF13238.6 EDO16987.1 - 0.02 15.4 0.1 9.7 6.7 0.0 3.5 3 0 0 3 3 3 0 AAA domain AAA_33 PF13671.6 EDO16987.1 - 0.021 15.0 0.1 1.1 9.4 0.1 2.7 2 0 0 2 2 2 0 AAA domain GTP_EFTU PF00009.27 EDO16987.1 - 0.033 13.7 0.1 11 5.5 0.0 2.9 3 0 0 3 3 3 0 Elongation factor Tu GTP binding domain cobW PF02492.19 EDO16987.1 - 0.041 13.5 8.0 0.066 12.8 0.1 3.4 3 0 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain MobB PF03205.14 EDO16987.1 - 0.045 13.7 2.0 2.8 7.9 0.1 2.6 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B Zeta_toxin PF06414.12 EDO16987.1 - 0.078 12.3 0.1 8.9 5.5 0.0 2.4 2 0 0 2 2 2 0 Zeta toxin AAA_7 PF12775.7 EDO16987.1 - 0.078 12.5 0.1 5 6.6 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region ATP_bind_1 PF03029.17 EDO16987.1 - 0.1 12.4 0.3 17 5.1 0.1 2.4 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_25 PF13481.6 EDO16987.1 - 0.11 12.1 0.0 17 4.9 0.0 2.4 2 0 0 2 2 2 0 AAA domain FtsK_SpoIIIE PF01580.18 EDO16987.1 - 0.12 11.7 0.1 4.6 6.5 0.0 2.2 2 0 0 2 2 2 0 FtsK/SpoIIIE family MeaB PF03308.16 EDO16987.1 - 0.15 11.0 0.0 0.42 9.6 0.0 1.7 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB ABC_ATPase PF09818.9 EDO16987.1 - 0.18 10.6 3.6 0.54 9.0 0.0 2.7 3 0 0 3 3 3 0 Predicted ATPase of the ABC class NACHT PF05729.12 EDO16987.1 - 0.18 11.7 2.1 0.95 9.4 0.2 2.4 2 0 0 2 2 2 0 NACHT domain PduV-EutP PF10662.9 EDO16987.1 - 0.2 11.4 1.4 9.5 6.0 0.1 2.6 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Dynamin_N PF00350.23 EDO16987.1 - 0.23 11.5 4.2 24 4.9 0.0 3.6 3 0 0 3 3 3 0 Dynamin family SAM_4 PF18017.1 EDO16987.1 - 0.26 11.3 2.8 1.2 9.1 0.2 3.4 3 1 1 4 4 4 0 SAM domain (Sterile alpha motif) AAA PF00004.29 EDO16987.1 - 0.32 11.4 3.8 3 8.3 0.3 3.7 3 1 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 EDO16987.1 - 0.52 10.0 2.9 10 5.8 1.1 2.7 2 1 0 2 2 2 0 AAA domain DEAD PF00270.29 EDO16987.1 - 0.53 10.0 4.3 2.4 7.9 0.2 3.3 3 1 0 3 3 3 0 DEAD/DEAH box helicase IstB_IS21 PF01695.17 EDO16987.1 - 0.98 9.1 3.8 2.9 7.6 0.0 3.0 4 0 0 4 4 2 0 IstB-like ATP binding protein Mak16 PF04874.14 EDO16987.1 - 1 10.0 5.7 4.3 8.0 5.7 2.0 1 0 0 1 1 1 0 Mak16 protein C-terminal region NTPase_1 PF03266.15 EDO16987.1 - 2.1 8.2 5.4 18 5.2 0.2 3.0 3 0 0 3 3 2 0 NTPase Peptidase_S10 PF00450.22 EDO16988.1 - 1.1e-101 341.3 0.3 1.5e-101 340.9 0.3 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase Nop14 PF04147.12 EDO16988.1 - 0.43 8.7 46.0 0.7 8.0 46.0 1.2 1 0 0 1 1 1 0 Nop14-like family Zip PF02535.22 EDO16988.1 - 1.7 7.8 5.6 5.8 6.0 5.8 1.8 2 0 0 2 2 2 0 ZIP Zinc transporter Presenilin PF01080.17 EDO16988.1 - 5.8 5.6 5.7 9.8 4.8 5.7 1.3 1 0 0 1 1 1 0 Presenilin UPF0113_N PF17833.1 EDO16989.1 - 5.7e-30 103.7 0.1 9e-30 103.1 0.1 1.3 1 0 0 1 1 1 1 UPF0113 Pre-PUA domain UPF0113 PF03657.13 EDO16989.1 - 5.1e-25 87.5 0.0 1.2e-24 86.3 0.0 1.7 1 0 0 1 1 1 1 UPF0113 PUA domain PUA PF01472.20 EDO16989.1 - 0.12 12.3 0.0 0.18 11.8 0.0 1.3 1 0 0 1 1 1 0 PUA domain SRP72 PF08492.12 EDO16990.1 - 9.4e-11 42.0 4.5 9.4e-11 42.0 4.5 2.5 2 0 0 2 2 2 1 SRP72 RNA-binding domain TPR_12 PF13424.6 EDO16990.1 - 1.9e-07 31.3 1.9 0.03 14.6 0.1 3.7 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 EDO16990.1 - 1e-05 25.3 2.9 3.3 8.1 0.0 4.7 5 0 0 5 5 5 3 Tetratricopeptide repeat SRP_TPR_like PF17004.5 EDO16990.1 - 7.2e-05 22.8 3.8 7.2e-05 22.8 3.8 3.3 1 1 1 2 2 2 1 Putative TPR-like repeat TPR_19 PF14559.6 EDO16990.1 - 0.0019 18.7 5.7 0.41 11.2 0.2 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.6 EDO16990.1 - 0.0031 17.4 0.1 6.7 7.0 0.0 4.4 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.6 EDO16990.1 - 0.011 16.3 2.1 95 4.0 0.1 5.4 5 0 0 5 5 5 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EDO16990.1 - 0.017 15.4 10.9 2.2 8.6 0.7 5.2 4 2 1 5 5 5 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_1 PF00515.28 EDO16990.1 - 0.019 14.8 1.1 34 4.5 0.1 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat PPR PF01535.20 EDO16990.1 - 0.031 14.5 0.0 39 4.8 0.0 4.0 4 0 0 4 4 4 0 PPR repeat Sgf11_N PF18519.1 EDO16990.1 - 0.052 13.1 0.0 0.23 11.1 0.0 2.2 1 0 0 1 1 1 0 SAGA-associated factor 11 N-terminal domain TPR_8 PF13181.6 EDO16990.1 - 0.22 11.9 0.1 0.22 11.9 0.1 4.9 6 0 0 6 6 5 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EDO16990.1 - 1.2 9.2 6.2 15 5.8 0.0 4.3 5 0 0 5 5 5 0 Fis1 C-terminal tetratricopeptide repeat Pkinase PF00069.25 EDO16991.1 - 5.3e-76 255.5 0.2 7.5e-76 255.0 0.2 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO16991.1 - 9.8e-47 159.4 0.0 1.3e-46 159.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDO16991.1 - 0.00014 21.3 0.0 0.00023 20.6 0.0 1.5 1 1 0 1 1 1 1 Kinase-like RIO1 PF01163.22 EDO16991.1 - 0.00035 20.2 0.4 0.0012 18.4 0.3 1.8 1 1 1 2 2 2 1 RIO1 family Haspin_kinase PF12330.8 EDO16991.1 - 0.016 14.1 0.2 0.016 14.1 0.2 1.8 2 0 0 2 2 2 0 Haspin like kinase domain Kdo PF06293.14 EDO16991.1 - 0.063 12.6 0.0 0.11 11.9 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 EDO16991.1 - 0.079 12.6 1.0 0.17 11.5 0.9 1.7 1 1 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 TFB6 PF17110.5 EDO16992.1 - 1.3e-31 109.7 0.0 3.5e-30 105.0 0.0 2.5 2 1 1 3 3 3 2 Subunit 11 of the general transcription factor TFIIH Pkinase PF00069.25 EDO16993.1 - 2e-06 27.4 0.0 2.6e-06 27.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain HLH PF00010.26 EDO16994.1 - 1.7e-20 72.7 0.1 4.5e-20 71.3 0.1 1.8 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain MMR_HSR1_Xtn PF16897.5 EDO16995.1 - 2.6e-38 130.3 0.0 5.1e-38 129.3 0.0 1.5 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain TGS PF02824.21 EDO16995.1 - 1.4e-22 79.5 0.0 2.4e-22 78.7 0.0 1.4 1 0 0 1 1 1 1 TGS domain MMR_HSR1 PF01926.23 EDO16995.1 - 1.8e-19 69.9 0.0 3.9e-19 68.8 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EDO16995.1 - 7.1e-09 35.4 0.1 1.8e-08 34.0 0.0 1.7 2 0 0 2 2 2 1 Ferrous iron transport protein B Dynamin_N PF00350.23 EDO16995.1 - 0.0071 16.4 0.3 5.5 7.0 0.0 2.4 1 1 1 2 2 2 2 Dynamin family MeaB PF03308.16 EDO16995.1 - 0.012 14.6 0.2 0.025 13.6 0.2 1.5 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_22 PF13401.6 EDO16995.1 - 0.017 15.4 0.1 10 6.4 0.0 2.6 3 0 0 3 3 3 0 AAA domain Arf PF00025.21 EDO16995.1 - 0.14 11.6 0.1 2.4 7.6 0.0 2.2 2 0 0 2 2 2 0 ADP-ribosylation factor family Mis12 PF05859.12 EDO16996.1 - 1.5e-42 144.9 2.9 1.5e-42 144.9 2.9 1.9 2 0 0 2 2 2 1 Mis12 protein WHEP-TRS PF00458.20 EDO16996.1 - 0.12 12.5 1.5 0.61 10.3 0.7 2.4 2 0 0 2 2 2 0 WHEP-TRS domain UQ_con PF00179.26 EDO16997.1 - 4.2e-48 162.6 0.0 4.8e-48 162.4 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EDO16997.1 - 0.00068 19.3 0.0 0.00088 19.0 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.13 EDO16997.1 - 0.0018 18.1 0.2 0.0032 17.3 0.2 1.4 1 1 0 1 1 1 1 UEV domain RWD PF05773.22 EDO16997.1 - 0.0018 18.5 0.1 0.0028 17.9 0.1 1.5 1 1 0 1 1 1 1 RWD domain AA_permease PF00324.21 EDO16998.1 - 1.5e-127 426.2 36.6 1.8e-127 425.8 36.6 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EDO16998.1 - 2.6e-31 108.9 35.2 3.3e-31 108.6 35.2 1.1 1 0 0 1 1 1 1 Amino acid permease TFIIS_C PF01096.18 EDO16999.1 - 3e-21 75.0 1.6 3e-21 75.0 1.6 2.5 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) RNA_POL_M_15KD PF02150.16 EDO16999.1 - 5.6e-14 51.7 4.3 1.3e-13 50.5 1.3 2.3 2 0 0 2 2 2 1 RNA polymerases M/15 Kd subunit Zn_Tnp_IS1595 PF12760.7 EDO16999.1 - 0.04 13.9 3.6 1.9 8.6 0.3 2.5 2 1 0 2 2 2 0 Transposase zinc-ribbon domain Elf1 PF05129.13 EDO16999.1 - 0.061 13.4 2.5 0.93 9.6 0.1 2.4 2 1 0 2 2 2 0 Transcription elongation factor Elf1 like zf-piccolo PF05715.13 EDO16999.1 - 0.23 11.7 0.6 0.23 11.7 0.6 2.8 3 0 0 3 3 3 0 Piccolo Zn-finger Baculo_LEF5_C PF11792.8 EDO16999.1 - 0.28 10.9 0.1 0.28 10.9 0.1 2.4 3 0 0 3 3 3 0 Baculoviridae late expression factor 5 C-terminal domain IBR PF01485.21 EDO16999.1 - 0.44 10.8 8.7 4 7.7 0.2 2.8 2 1 0 2 2 2 0 IBR domain, a half RING-finger domain PhnA_Zn_Ribbon PF08274.12 EDO16999.1 - 0.65 10.0 8.0 1.6 8.8 0.3 3.0 3 0 0 3 3 3 0 PhnA Zinc-Ribbon zf-C2H2 PF00096.26 EDO17000.1 - 2.1e-07 31.0 12.6 2.7e-05 24.4 3.4 2.5 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EDO17000.1 - 6.8e-05 23.1 16.3 0.00022 21.5 2.2 3.1 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_11 PF16622.5 EDO17000.1 - 0.00028 20.6 1.2 0.00063 19.4 1.2 1.5 1 0 0 1 1 1 1 zinc-finger C2H2-type zf-C2H2_4 PF13894.6 EDO17000.1 - 0.0044 17.7 9.7 0.077 13.9 1.9 2.6 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_3rep PF18868.1 EDO17000.1 - 0.015 16.0 3.1 0.016 15.9 1.8 2.0 1 1 0 1 1 1 0 Zinc finger C2H2-type, 3 repeats zf-Dof PF02701.15 EDO17000.1 - 0.019 15.1 0.4 0.054 13.6 0.4 1.8 1 0 0 1 1 1 0 Dof domain, zinc finger zf-C2H2_8 PF15909.5 EDO17000.1 - 0.036 14.4 3.4 3.7 7.9 0.0 2.6 1 1 1 2 2 2 0 C2H2-type zinc ribbon Zn_Tnp_IS1595 PF12760.7 EDO17000.1 - 0.078 13.0 0.7 0.078 13.0 0.7 1.8 2 0 0 2 2 2 0 Transposase zinc-ribbon domain zf-met PF12874.7 EDO17000.1 - 0.24 11.8 6.2 0.36 11.3 0.4 3.0 2 1 0 2 2 2 0 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EDO17000.1 - 0.84 10.0 0.1 0.84 10.0 0.1 3.3 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding TFIIA PF03153.13 EDO17000.1 - 1.4 8.9 10.6 1.5 8.7 10.6 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit zf-C2H2_6 PF13912.6 EDO17000.1 - 1.8 8.7 6.3 0.27 11.3 1.3 2.2 2 1 0 2 2 2 0 C2H2-type zinc finger ComA PF02679.15 EDO17001.1 - 0.0041 16.6 0.0 0.0068 15.9 0.0 1.3 1 0 0 1 1 1 1 (2R)-phospho-3-sulfolactate synthase (ComA) Spermine_synth PF01564.17 EDO17002.1 - 1.9e-74 249.2 0.0 2.6e-74 248.7 0.0 1.2 1 0 0 1 1 1 1 Spermine/spermidine synthase domain Spermine_synt_N PF17284.2 EDO17002.1 - 1.7e-26 91.8 0.1 3e-26 91.1 0.1 1.4 1 0 0 1 1 1 1 Spermidine synthase tetramerisation domain Methyltransf_25 PF13649.6 EDO17002.1 - 0.0004 21.0 0.0 0.00071 20.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EDO17002.1 - 0.0044 17.7 0.1 0.017 15.9 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain DUF43 PF01861.16 EDO17002.1 - 0.031 13.5 0.0 0.052 12.8 0.0 1.3 1 0 0 1 1 1 0 Branched-chain polyamine synthase A C-terminal domain Methyltransf_18 PF12847.7 EDO17002.1 - 0.075 13.0 0.0 0.13 12.1 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Glycos_transf_1 PF00534.20 EDO17003.1 - 1.7e-11 43.9 0.0 3.1e-11 43.1 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 EDO17003.1 - 6.9e-07 29.8 0.0 7.4e-06 26.4 0.0 2.1 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 EDO17003.1 - 2.7e-06 27.5 0.0 3.9e-06 27.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_1_2 PF13524.6 EDO17003.1 - 0.00093 19.5 0.0 0.0017 18.7 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 DarA_N PF18788.1 EDO17004.1 - 0.012 15.6 0.2 0.025 14.7 0.1 1.6 2 0 0 2 2 2 0 Defence against restriction A N-terminal CENP-L PF13092.6 EDO17004.1 - 0.047 13.9 0.2 0.22 11.8 0.2 2.1 1 1 0 1 1 1 0 Kinetochore complex Sim4 subunit Fta1 Fe-S_biosyn PF01521.20 EDO17005.1 - 9.1e-12 45.2 0.4 3.9e-05 23.8 0.1 2.4 1 1 1 2 2 2 2 Iron-sulphur cluster biosynthesis ThiF PF00899.21 EDO17006.1 - 4.5e-53 180.1 0.1 5.9e-53 179.7 0.1 1.0 1 0 0 1 1 1 1 ThiF family TrkA_N PF02254.18 EDO17006.1 - 0.0021 18.3 0.5 1.2 9.4 0.0 2.4 2 0 0 2 2 2 2 TrkA-N domain PglD_N PF17836.1 EDO17006.1 - 0.017 15.7 1.4 0.075 13.7 0.1 2.6 3 0 0 3 3 3 0 PglD N-terminal domain Sacchrp_dh_NADP PF03435.18 EDO17006.1 - 0.038 14.3 0.0 0.13 12.5 0.0 1.9 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain Pho88 PF10032.9 EDO17007.1 - 2.8e-81 271.1 1.2 3.2e-81 271.0 1.2 1.0 1 0 0 1 1 1 1 Phosphate transport (Pho88) Glucos_trans_II PF14264.6 EDO17007.1 - 0.0023 17.3 1.6 0.0028 17.1 1.6 1.1 1 0 0 1 1 1 1 Glucosyl transferase GtrII Vac_ImportDeg PF09783.9 EDO17008.1 - 2.6e-57 193.2 1.4 3.5e-57 192.7 1.4 1.2 1 0 0 1 1 1 1 Vacuolar import and degradation protein UPF0139 PF03669.13 EDO17009.1 - 2.1e-07 30.7 0.2 4.2e-07 29.7 0.2 1.4 1 1 0 1 1 1 1 Uncharacterised protein family (UPF0139) dCMP_cyt_deam_1 PF00383.23 EDO17010.1 - 2.9e-21 75.2 0.0 3.8e-21 74.8 0.0 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 EDO17010.1 - 3.8e-18 65.6 0.0 5e-18 65.2 0.0 1.1 1 0 0 1 1 1 1 MafB19-like deaminase SNAD4 PF18750.1 EDO17010.1 - 0.00042 20.4 0.0 0.00066 19.8 0.0 1.3 1 0 0 1 1 1 1 Secreted Novel AID/APOBEC-like Deaminase 4 Bd3614-deam PF14439.6 EDO17010.1 - 0.0014 18.7 0.2 0.0066 16.5 0.1 2.0 1 1 1 2 2 2 1 Bd3614-like deaminase NAD1 PF18778.1 EDO17010.1 - 0.0037 17.4 0.0 0.023 14.8 0.0 1.9 2 0 0 2 2 2 1 Novel AID APOBEC clade 1 APOBEC2 PF18772.1 EDO17010.1 - 0.0084 16.2 0.0 0.043 13.9 0.0 1.8 2 0 0 2 2 2 1 APOBEC2 NAD2 PF18782.1 EDO17010.1 - 0.043 13.9 0.0 0.14 12.3 0.0 1.7 2 0 0 2 2 2 0 Novel AID APOBEC clade 2 Inv-AAD PF18785.1 EDO17010.1 - 0.058 13.3 0.6 0.22 11.4 0.6 2.1 1 1 0 1 1 1 0 Invertebrate-AID/APOBEC-deaminase APOBEC4_like PF18774.1 EDO17010.1 - 0.13 12.2 0.0 0.16 11.9 0.0 1.3 1 0 0 1 1 1 0 APOBEC4-like -AID/APOBEC-deaminase XOO_2897-deam PF14440.6 EDO17010.1 - 0.21 11.7 0.0 0.31 11.2 0.0 1.3 1 0 0 1 1 1 0 Xanthomonas XOO_2897-like deaminase Mito_carr PF00153.27 EDO17011.1 - 1.1e-56 188.7 3.8 2.1e-21 75.7 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein FOXP-CC PF16159.5 EDO17012.1 - 0.027 15.1 3.2 0.082 13.6 0.1 2.4 1 1 1 2 2 2 0 FOXP coiled-coil domain zf-C2H2_jaz PF12171.8 EDO17012.1 - 0.83 10.0 12.6 0.87 10.0 0.6 3.5 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 EDO17012.1 - 1.8 9.6 12.4 2 9.5 0.3 3.6 3 1 0 3 3 3 0 C2H2-type zinc finger Tfb4 PF03850.14 EDO17013.1 - 0.0092 15.5 0.0 0.011 15.3 0.0 1.1 1 0 0 1 1 1 1 Transcription factor Tfb4 WD40 PF00400.32 EDO17014.1 - 1.2e-17 63.9 13.0 0.0007 20.4 0.0 6.3 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDO17014.1 - 3.9e-16 59.1 4.5 0.00045 20.5 0.0 6.3 1 1 6 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain LisH PF08513.11 EDO17014.1 - 1.4e-08 34.4 0.1 2.4e-08 33.6 0.1 1.4 1 0 0 1 1 1 1 LisH WD40_like PF17005.5 EDO17014.1 - 8.2e-08 31.9 0.5 0.00015 21.3 0.1 3.4 1 1 1 3 3 3 1 WD40-like domain BBS2_Mid PF14783.6 EDO17014.1 - 7.5e-06 25.9 0.2 0.24 11.5 0.0 4.3 2 2 1 4 4 4 1 Ciliary BBSome complex subunit 2, middle region RAB3GAP2_N PF14655.6 EDO17014.1 - 6.4e-05 22.4 0.1 0.0017 17.7 0.0 2.3 2 0 0 2 2 2 1 Rab3 GTPase-activating protein regulatory subunit N-terminus eIF2A PF08662.11 EDO17014.1 - 0.00011 22.1 1.4 0.084 12.7 0.2 3.3 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Vps16_N PF04841.13 EDO17014.1 - 0.0039 16.0 0.1 0.064 12.0 0.0 2.5 2 1 1 3 3 3 1 Vps16, N-terminal region Lactamase_B_5 PF14597.6 EDO17014.1 - 0.037 13.5 0.0 0.073 12.6 0.0 1.4 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily Exo84_C PF16528.5 EDO17015.1 - 2.1e-70 236.7 3.5 2.1e-70 236.7 3.5 2.1 2 0 0 2 2 2 1 Exocyst component 84 C-terminal Vps51 PF08700.11 EDO17015.1 - 3e-09 36.8 0.8 3e-09 36.8 0.8 3.2 3 0 0 3 3 3 1 Vps51/Vps67 COG2 PF06148.11 EDO17015.1 - 0.011 15.9 9.3 0.011 15.8 1.2 2.9 2 1 1 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 BAF PF02961.14 EDO17015.1 - 0.019 15.4 0.2 0.09 13.2 0.2 2.2 1 0 0 1 1 1 0 Barrier to autointegration factor Pkinase PF00069.25 EDO17016.1 - 8.6e-23 81.0 2.1 5.2e-13 49.0 1.1 2.9 1 1 1 2 2 2 2 Protein kinase domain HEAT PF02985.22 EDO17016.1 - 2e-08 33.8 2.7 0.31 11.4 0.0 6.5 7 0 0 7 7 7 2 HEAT repeat Pkinase_Tyr PF07714.17 EDO17016.1 - 8.1e-08 31.9 0.3 9.8e-05 21.8 0.0 2.5 2 0 0 2 2 2 2 Protein tyrosine kinase HEAT_2 PF13646.6 EDO17016.1 - 0.0003 21.1 0.0 0.0081 16.5 0.0 3.0 3 1 0 3 3 3 1 HEAT repeats DDHD PF02862.17 EDO17016.1 - 0.0019 18.4 0.6 0.012 15.8 0.5 2.3 2 0 0 2 2 2 1 DDHD domain EPL1 PF10513.9 EDO17016.1 - 0.002 18.5 4.3 0.0076 16.6 4.3 2.1 1 0 0 1 1 1 1 Enhancer of polycomb-like DUF4834 PF16118.5 EDO17016.1 - 0.0078 17.2 3.4 0.065 14.2 2.8 2.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4834) TFIIA PF03153.13 EDO17016.1 - 0.013 15.5 23.9 0.022 14.8 23.9 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit RR_TM4-6 PF06459.12 EDO17016.1 - 0.08 12.8 8.5 0.15 11.9 8.5 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 TERB2 PF15101.6 EDO17016.1 - 0.22 11.6 11.1 0.53 10.3 11.1 1.6 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Neur_chan_memb PF02932.16 EDO17016.1 - 0.22 11.5 2.9 0.44 10.6 2.9 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Pex14_N PF04695.13 EDO17016.1 - 0.82 10.3 20.8 1.6 9.4 20.8 1.4 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF4175 PF13779.6 EDO17016.1 - 1.2 6.9 26.4 1.8 6.4 26.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Gti1_Pac2 PF09729.9 EDO17016.1 - 1.7 8.7 8.6 5.1 7.2 8.6 1.8 1 0 0 1 1 1 0 Gti1/Pac2 family RP-C_C PF11800.8 EDO17016.1 - 2.6 8.1 9.3 4.7 7.3 9.3 1.3 1 0 0 1 1 1 0 Replication protein C C-terminal region EIIBC-GUT_N PF03612.14 EDO17016.1 - 2.7 7.7 8.0 7 6.4 8.0 1.6 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Endostatin PF06482.11 EDO17016.1 - 3.1 7.2 11.1 19 4.6 11.8 1.8 2 0 0 2 2 2 0 Collagenase NC10 and Endostatin DUF4638 PF15472.6 EDO17016.1 - 3.6 7.2 8.5 15 5.2 6.3 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4638) Roughex PF06020.11 EDO17016.1 - 5.1 6.1 9.8 9.4 5.2 9.8 1.3 1 0 0 1 1 1 0 Drosophila roughex protein 4HBT_2 PF13279.6 EDO17017.1 - 2.2e-08 34.6 0.0 3.4e-08 34.0 0.0 1.3 1 0 0 1 1 1 1 Thioesterase-like superfamily HMG_box PF00505.19 EDO17018.1 - 1.6e-25 89.3 0.6 2.5e-25 88.7 0.6 1.3 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EDO17018.1 - 1.7e-17 63.8 0.8 2.4e-17 63.3 0.8 1.2 1 0 0 1 1 1 1 HMG-box domain Ccdc124 PF06244.12 EDO17018.1 - 0.0013 19.3 0.9 0.0032 18.0 0.0 1.8 1 1 1 2 2 2 1 Coiled-coil domain-containing protein 124 /Oxs1 CHDNT PF08073.12 EDO17018.1 - 0.0029 17.5 0.0 0.0047 16.9 0.0 1.3 1 0 0 1 1 1 1 CHDNT (NUC034) domain YABBY PF04690.13 EDO17018.1 - 0.0097 16.5 1.2 0.011 16.4 0.6 1.4 1 1 1 2 2 2 1 YABBY protein Acetyltransf_1 PF00583.25 EDO17019.1 - 2.2e-19 69.8 0.0 2.6e-19 69.6 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EDO17019.1 - 1.8e-12 47.5 0.0 2.4e-12 47.1 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EDO17019.1 - 9.4e-11 41.7 0.0 1.3e-10 41.3 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EDO17019.1 - 1.4e-09 37.8 0.1 2.3e-09 37.1 0.1 1.2 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_3 PF13302.7 EDO17019.1 - 0.00016 22.3 0.0 0.0002 22.1 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EDO17019.1 - 0.0004 20.4 0.0 0.00088 19.4 0.0 1.6 1 1 1 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 EDO17019.1 - 0.0053 16.9 0.2 0.0062 16.7 0.2 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_15 PF17013.5 EDO17019.1 - 0.0068 15.9 0.5 0.021 14.3 0.5 1.8 1 1 0 1 1 1 1 Putative acetyl-transferase DUF444 PF04285.12 EDO17019.1 - 0.02 14.0 0.0 0.025 13.7 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF444) Acetyltransf_8 PF13523.6 EDO17019.1 - 0.031 14.0 0.0 0.043 13.5 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Ku PF02735.16 EDO17019.1 - 0.047 13.4 0.0 0.058 13.1 0.0 1.1 1 0 0 1 1 1 0 Ku70/Ku80 beta-barrel domain Acetyltransf_CG PF14542.6 EDO17019.1 - 0.11 12.6 0.0 0.2 11.8 0.0 1.4 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase ATG11 PF10377.9 EDO17020.1 - 4e-41 140.1 0.1 4e-41 140.1 0.1 4.2 4 0 0 4 4 4 1 Autophagy-related protein 11 ZapB PF06005.12 EDO17020.1 - 0.00025 21.4 6.3 0.00025 21.4 6.3 6.6 7 3 0 7 7 7 2 Cell division protein ZapB Adaptin_N PF01602.20 EDO17021.1 - 3.2e-107 359.3 28.4 4e-107 358.9 28.4 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptin_C PF02296.16 EDO17021.1 - 4.7e-08 33.2 0.0 1.2e-07 31.9 0.0 1.7 1 0 0 1 1 1 1 Alpha adaptin AP2, C-terminal domain Alpha_adaptinC2 PF02883.20 EDO17021.1 - 6.8e-05 23.1 1.7 0.00029 21.1 1.7 2.1 1 0 0 1 1 1 1 Adaptin C-terminal domain zinc_ribbon_15 PF17032.5 EDO17023.1 - 2.4e-05 25.0 1.4 3.5e-05 24.5 1.4 1.4 1 1 0 1 1 1 1 zinc-ribbon family Rubredoxin PF00301.20 EDO17023.1 - 0.0017 18.4 4.4 0.056 13.5 0.4 2.5 2 0 0 2 2 2 2 Rubredoxin zf-RING_5 PF14634.6 EDO17023.1 - 0.038 14.0 0.1 0.074 13.0 0.1 1.5 1 0 0 1 1 1 0 zinc-RING finger domain DUF4872 PF16169.5 EDO17023.1 - 0.083 12.6 0.1 0.11 12.3 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4872) Cys_rich_KTR PF14205.6 EDO17023.1 - 0.12 12.2 1.2 0.81 9.5 0.2 2.2 2 0 0 2 2 2 0 Cysteine-rich KTR zinc_ribbon_4 PF13717.6 EDO17023.1 - 0.2 11.6 2.6 2.5 8.1 0.1 2.3 2 0 0 2 2 2 0 zinc-ribbon domain Androgen_recep PF02166.16 EDO17023.1 - 5.7 5.7 9.3 6.5 5.5 9.3 1.1 1 0 0 1 1 1 0 Androgen receptor Spt20 PF12090.8 EDO17023.1 - 6.4 6.3 13.3 8.4 5.9 13.3 1.1 1 0 0 1 1 1 0 Spt20 family Ribosomal_L19e PF01280.20 EDO17024.1 - 2.5e-59 199.5 10.3 2.5e-59 199.5 10.3 1.5 2 0 0 2 2 2 1 Ribosomal protein L19e TilS PF09179.11 EDO17024.1 - 0.32 11.5 7.0 82 3.8 7.8 3.1 2 1 0 2 2 2 0 TilS substrate binding domain TEA PF01285.18 EDO17025.1 - 8.6e-24 83.4 0.5 2.3e-23 82.0 0.2 1.9 2 0 0 2 2 2 1 TEA/ATTS domain PRKCSH PF07915.13 EDO17026.1 - 2.5e-11 44.4 0.9 7.7e-11 42.8 0.9 1.9 1 0 0 1 1 1 1 Glucosidase II beta subunit-like protein Yos9_DD PF17880.1 EDO17026.1 - 2.5e-10 40.5 0.7 9.5e-10 38.7 0.7 2.0 1 1 0 1 1 1 1 Yos9 dimerzation domain PRKCSH_1 PF13015.6 EDO17026.1 - 0.0003 20.5 2.3 0.00052 19.7 1.4 1.9 1 1 1 2 2 2 1 Glucosidase II beta subunit-like protein GIY-YIG PF01541.24 EDO17026.1 - 0.058 13.7 0.3 0.15 12.4 0.3 1.7 1 0 0 1 1 1 0 GIY-YIG catalytic domain PCI PF01399.27 EDO17027.1 - 9.5e-06 26.1 4.5 2.1e-05 25.0 0.1 3.1 2 1 0 2 2 2 1 PCI domain Helicase_C PF00271.31 EDO17027.1 - 0.019 15.3 0.7 0.48 10.8 0.1 2.8 2 1 0 2 2 2 0 Helicase conserved C-terminal domain UQ_con PF00179.26 EDO17028.1 - 2.1e-44 150.6 0.1 3.3e-44 149.9 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EDO17028.1 - 0.003 17.2 0.0 0.011 15.5 0.0 1.8 1 1 0 1 1 1 1 Prokaryotic E2 family B AMNp_N PF10423.9 EDO17028.1 - 0.065 12.9 0.2 0.12 12.1 0.1 1.4 1 1 0 1 1 1 0 Bacterial AMP nucleoside phosphorylase N-terminus DUF2990 PF11693.8 EDO17028.1 - 0.57 10.4 2.3 6.7 6.9 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2990) SLM4 PF16818.5 EDO17029.1 - 3.2e-66 222.2 2.5 3.6e-66 222.1 2.5 1.0 1 0 0 1 1 1 1 Protein SLM4 Dfp1_Him1_M PF08630.10 EDO17030.1 - 2.9e-41 140.7 0.1 2.9e-41 140.7 0.1 3.1 4 0 0 4 4 4 1 Dfp1/Him1, central region zf-DBF PF07535.12 EDO17030.1 - 4.5e-21 74.7 0.7 9e-21 73.7 0.7 1.5 1 0 0 1 1 1 1 DBF zinc finger zf-C2H2 PF00096.26 EDO17031.1 - 1.6e-11 44.0 7.2 4.9e-06 26.7 0.9 3.1 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EDO17031.1 - 5.1e-07 29.8 12.1 1.3e-05 25.4 0.4 3.2 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 EDO17031.1 - 4e-05 24.1 6.5 0.0078 17.0 0.6 2.9 2 0 0 2 2 2 2 C2H2-type zinc finger zf-met PF12874.7 EDO17031.1 - 0.00064 20.0 8.3 0.0011 19.3 0.4 3.0 3 0 0 3 3 3 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EDO17031.1 - 0.025 14.9 4.0 0.048 14.0 0.1 2.9 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding Zn_ribbon_SprT PF17283.2 EDO17031.1 - 0.034 14.0 0.7 0.034 14.0 0.7 1.8 2 0 0 2 2 2 0 SprT-like zinc ribbon domain zf-C2H2_6 PF13912.6 EDO17031.1 - 0.038 14.0 0.5 0.038 14.0 0.5 2.0 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_8 PF15909.5 EDO17031.1 - 0.23 11.8 7.4 0.85 10.0 0.3 2.6 1 1 1 2 2 2 0 C2H2-type zinc ribbon RXT2_N PF08595.11 EDO17032.1 - 0.042 13.9 0.3 0.11 12.6 0.3 1.6 1 0 0 1 1 1 0 RXT2-like, N-terminal DbpA PF03880.15 EDO17032.1 - 0.14 12.2 0.0 3.4 7.7 0.0 2.5 2 0 0 2 2 2 0 DbpA RNA binding domain DUF2457 PF10446.9 EDO17032.1 - 0.15 11.2 4.7 0.22 10.6 4.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) CENP-B_dimeris PF09026.10 EDO17032.1 - 1.2 9.6 10.6 2.6 8.5 10.6 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Cwf_Cwc_15 PF04889.12 EDO17032.1 - 5.4 6.7 8.7 8.1 6.1 8.7 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Septin PF00735.18 EDO17033.1 - 5.7e-112 373.6 1.1 9.8e-112 372.8 1.1 1.3 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 EDO17033.1 - 1.9e-07 31.2 0.1 4.4e-07 30.0 0.1 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EDO17033.1 - 1e-05 25.5 5.1 5.9e-05 23.0 0.0 3.2 3 0 0 3 3 3 1 RsgA GTPase GTP_EFTU PF00009.27 EDO17033.1 - 4.3e-05 23.2 2.0 0.0012 18.4 0.1 2.7 2 2 0 2 2 2 1 Elongation factor Tu GTP binding domain AAA_22 PF13401.6 EDO17033.1 - 0.00023 21.5 0.0 0.00058 20.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain Roc PF08477.13 EDO17033.1 - 0.0038 17.4 0.4 0.012 15.8 0.0 2.1 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase AAA_24 PF13479.6 EDO17033.1 - 0.0042 16.8 0.2 0.012 15.3 0.2 1.7 1 1 0 1 1 1 1 AAA domain IIGP PF05049.13 EDO17033.1 - 0.0045 16.1 0.0 0.0099 15.0 0.0 1.6 1 0 0 1 1 1 1 Interferon-inducible GTPase (IIGP) Dynamin_N PF00350.23 EDO17033.1 - 0.0056 16.8 4.8 1.6 8.8 0.0 3.3 2 1 1 3 3 3 1 Dynamin family Gtr1_RagA PF04670.12 EDO17033.1 - 0.0096 15.3 0.1 0.12 11.8 0.0 2.3 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region KAP_NTPase PF07693.14 EDO17033.1 - 0.0097 15.2 0.0 0.025 13.8 0.0 1.9 1 1 1 2 2 2 1 KAP family P-loop domain AIG1 PF04548.16 EDO17033.1 - 0.013 14.8 0.1 0.013 14.8 0.1 2.0 2 0 0 2 2 2 0 AIG1 family AAA_7 PF12775.7 EDO17033.1 - 0.015 14.8 0.0 0.029 13.9 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region RNA_helicase PF00910.22 EDO17033.1 - 0.022 15.1 0.0 0.053 13.9 0.0 1.7 1 0 0 1 1 1 0 RNA helicase Pox_A32 PF04665.12 EDO17033.1 - 0.023 14.1 0.7 0.035 13.6 0.0 1.6 2 0 0 2 2 2 0 Poxvirus A32 protein FtsK_SpoIIIE PF01580.18 EDO17033.1 - 0.032 13.6 0.0 0.063 12.6 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family Sigma54_activat PF00158.26 EDO17033.1 - 0.033 13.9 0.0 0.069 12.9 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain DUF3987 PF13148.6 EDO17033.1 - 0.041 12.9 0.0 1 8.3 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3987) NACHT PF05729.12 EDO17033.1 - 0.081 12.8 0.0 0.2 11.6 0.0 1.7 1 0 0 1 1 1 0 NACHT domain AAA_16 PF13191.6 EDO17033.1 - 0.11 12.8 0.0 0.29 11.5 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain ABC_tran PF00005.27 EDO17033.1 - 0.14 12.7 0.2 0.14 12.7 0.2 2.1 2 1 0 2 2 2 0 ABC transporter AAA_33 PF13671.6 EDO17033.1 - 0.14 12.3 0.4 0.49 10.6 0.0 2.0 2 0 0 2 2 2 0 AAA domain PduV-EutP PF10662.9 EDO17033.1 - 0.25 11.1 1.5 0.74 9.6 0.2 2.4 2 1 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Pyr_redox_2 PF07992.14 EDO17034.1 - 9.3e-50 169.5 0.1 1.1e-49 169.3 0.1 1.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EDO17034.1 - 4e-19 69.0 0.8 2.4e-16 60.0 0.1 3.1 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EDO17034.1 - 9.5e-16 57.9 0.0 1.1e-14 54.4 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EDO17034.1 - 0.00047 19.3 3.6 1.5 7.8 0.1 4.3 3 1 1 5 5 5 2 Glucose inhibited division protein A NAD_binding_7 PF13241.6 EDO17034.1 - 0.0021 18.5 0.0 0.11 13.0 0.0 2.4 2 1 0 2 2 2 1 Putative NAD(P)-binding NAD_binding_8 PF13450.6 EDO17034.1 - 0.0033 17.6 0.0 0.26 11.5 0.0 2.5 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.6 EDO17034.1 - 0.0056 15.9 0.0 0.62 9.1 0.0 3.0 2 1 1 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) FAD_binding_2 PF00890.24 EDO17034.1 - 0.025 13.7 0.4 1.1 8.3 0.1 2.7 2 2 1 3 3 3 0 FAD binding domain Thi4 PF01946.17 EDO17034.1 - 0.035 13.3 0.0 0.15 11.3 0.0 1.9 2 0 0 2 2 2 0 Thi4 family HI0933_like PF03486.14 EDO17034.1 - 0.043 12.5 0.1 8.6 4.9 0.0 2.8 2 1 0 3 3 3 0 HI0933-like protein FAD_binding_3 PF01494.19 EDO17034.1 - 0.049 12.9 0.0 8.2 5.6 0.0 2.2 2 0 0 2 2 2 0 FAD binding domain PX PF00787.24 EDO17035.1 - 3.2e-15 56.1 0.0 4.1e-15 55.8 0.0 1.2 1 0 0 1 1 1 1 PX domain DNA_ligase_A_M PF01068.21 EDO17035.1 - 0.034 13.8 0.0 0.042 13.5 0.0 1.1 1 0 0 1 1 1 0 ATP dependent DNA ligase domain PQ-loop PF04193.14 EDO17036.1 - 6.8e-36 121.8 11.0 3.6e-18 65.1 0.4 2.6 3 0 0 3 3 3 2 PQ loop repeat MtN3_slv PF03083.16 EDO17036.1 - 0.00053 20.0 4.6 0.19 11.8 0.1 3.4 2 1 1 3 3 3 3 Sugar efflux transporter for intercellular exchange ER_lumen_recept PF00810.18 EDO17036.1 - 0.0095 16.8 5.4 0.026 15.3 0.0 2.9 2 1 0 2 2 2 1 ER lumen protein retaining receptor SBE2 PF17076.5 EDO17037.1 - 0 1449.6 28.9 0 1449.5 28.9 1.0 1 0 0 1 1 1 1 SBE2, cell-wall formation PGP_phosphatase PF09419.10 EDO17038.1 - 3e-70 235.2 0.0 3.4e-70 235.0 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial PGP phosphatase Hydrolase_like PF13242.6 EDO17038.1 - 2e-05 24.6 0.0 3.2e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 HAD-hyrolase-like YEATS PF03366.16 EDO17039.1 - 1.9e-20 72.6 0.1 3.3e-20 71.9 0.1 1.4 1 0 0 1 1 1 1 YEATS family BET PF17035.5 EDO17039.1 - 1.5e-05 25.0 0.3 2.6e-05 24.3 0.3 1.4 1 0 0 1 1 1 1 Bromodomain extra-terminal - transcription regulation YEATS PF03366.16 EDO17040.1 - 3.5e-17 62.2 0.2 1.2e-16 60.5 0.0 2.0 2 0 0 2 2 2 1 YEATS family TRF PF08558.10 EDO17041.1 - 1.3e-70 237.7 12.0 1.8e-70 237.2 12.0 1.2 1 0 0 1 1 1 1 Telomere repeat binding factor (TRF) Myb_DNA-binding PF00249.31 EDO17041.1 - 1.7e-07 31.3 0.3 3.7e-07 30.2 0.3 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EDO17041.1 - 0.015 15.5 0.1 0.059 13.6 0.1 2.1 1 0 0 1 1 1 0 Myb-like DNA-binding domain RnlB_antitoxin PF15933.5 EDO17041.1 - 0.079 13.3 2.4 0.57 10.5 0.0 3.3 2 1 0 2 2 2 0 Antitoxin to bacterial toxin RNase LS or RnlA IBN_N PF03810.19 EDO17042.1 - 2.4e-14 53.0 0.8 8.5e-14 51.2 0.8 2.1 1 0 0 1 1 1 1 Importin-beta N-terminal domain Xpo1 PF08389.12 EDO17042.1 - 0.00052 20.1 9.1 0.13 12.3 0.8 4.6 4 1 0 4 4 4 2 Exportin 1-like protein Spc29 PF17082.5 EDO17043.1 - 2.3e-22 80.1 17.2 5.2e-22 78.9 17.2 1.6 1 1 0 1 1 1 1 Spindle Pole Component 29 DUF4113 PF13438.6 EDO17043.1 - 0.12 12.5 0.2 5.7 7.1 0.1 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4113) Filament PF00038.21 EDO17043.1 - 0.16 11.5 6.8 0.18 11.3 1.6 2.3 2 0 0 2 2 2 0 Intermediate filament protein DUF745 PF05335.13 EDO17043.1 - 0.37 10.5 1.3 2.2 8.0 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF745) FapA PF03961.13 EDO17043.1 - 1.1 7.7 4.7 5.4 5.5 0.3 2.1 2 0 0 2 2 2 0 Flagellar Assembly Protein A Edc3_linker PF16598.5 EDO17043.1 - 5.8 7.7 9.9 2.9 8.6 7.0 2.0 2 0 0 2 2 2 0 Linker region of enhancer of mRNA-decapping protein 3 Ribonuclease_T2 PF00445.18 EDO17044.1 - 8.9e-43 146.6 0.2 1.5e-42 145.9 0.2 1.3 1 0 0 1 1 1 1 Ribonuclease T2 family aGPT-Pplase1 PF18723.1 EDO17044.1 - 0.0081 15.6 0.6 0.025 14.0 0.1 1.8 2 0 0 2 2 2 1 alpha-glutamyl/putrescinyl thymine pyrophosphorylase clade 1 Sec61_beta PF03911.16 EDO17045.1 - 1.3e-15 57.1 1.1 1.5e-15 56.9 1.1 1.1 1 0 0 1 1 1 1 Sec61beta family Fe_hyd_SSU PF02256.17 EDO17045.1 - 0.055 13.6 0.1 0.071 13.2 0.1 1.1 1 0 0 1 1 1 0 Iron hydrogenase small subunit PALP PF00291.25 EDO17046.1 - 3.7e-78 262.9 0.1 5.5e-78 262.4 0.1 1.2 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Thr_dehydrat_C PF00585.18 EDO17046.1 - 2.7e-42 142.5 0.1 1.9e-28 98.0 0.0 2.6 2 0 0 2 2 2 2 C-terminal regulatory domain of Threonine dehydratase MMR1 PF08505.10 EDO17047.1 - 1.4e-81 274.6 24.5 1.4e-81 274.6 24.5 2.4 2 0 0 2 2 2 1 Mitochondrial Myo2 receptor-related protein Cob_adeno_trans PF01923.18 EDO17047.1 - 5.8 7.0 7.2 15 5.7 0.1 3.3 1 1 2 3 3 3 0 Cobalamin adenosyltransferase Peroxin-13_N PF04088.13 EDO17048.1 - 3e-47 160.5 0.8 4.6e-47 159.9 0.8 1.2 1 0 0 1 1 1 1 Peroxin 13, N-terminal region SH3_2 PF07653.17 EDO17048.1 - 2.9e-09 36.5 0.0 6.1e-09 35.4 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EDO17048.1 - 2.3e-08 33.5 0.0 4.6e-08 32.6 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EDO17048.1 - 1e-06 28.5 0.0 2.2e-06 27.4 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_3 PF08239.11 EDO17048.1 - 0.00025 21.2 0.1 0.00044 20.5 0.1 1.3 1 0 0 1 1 1 1 Bacterial SH3 domain SH3_10 PF17902.1 EDO17048.1 - 0.038 14.0 0.0 0.093 12.8 0.0 1.7 1 0 0 1 1 1 0 SH3 domain RlmM_FDX PF18125.1 EDO17048.1 - 0.17 12.4 0.1 0.35 11.4 0.1 1.5 1 0 0 1 1 1 0 RlmM ferredoxin-like domain FAD-oxidase_C PF02913.19 EDO17049.1 - 1.2e-61 208.5 0.1 6.5e-60 202.9 0.1 2.1 2 0 0 2 2 2 2 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 EDO17049.1 - 3.9e-34 117.4 0.0 7.1e-34 116.5 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain DUF3602 PF12223.8 EDO17050.1 - 0.00077 20.0 1.4 0.00077 20.0 1.4 2.1 2 1 0 2 2 2 1 Protein of unknown function (DUF3602) DUF1633 PF07794.11 EDO17050.1 - 0.16 10.1 3.3 0.19 9.9 3.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1633) GATase_2 PF00310.21 EDO17051.1 - 4.2e-169 562.7 0.0 6.8e-169 562.0 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferases class-II Glu_synthase PF01645.17 EDO17051.1 - 9.7e-153 508.6 0.0 1.7e-152 507.8 0.0 1.4 1 0 0 1 1 1 1 Conserved region in glutamate synthase Glu_syn_central PF04898.14 EDO17051.1 - 2.7e-113 378.1 0.0 5e-110 367.4 0.0 2.5 2 0 0 2 2 2 2 Glutamate synthase central domain GXGXG PF01493.19 EDO17051.1 - 2.3e-70 236.0 2.6 4.4e-70 235.2 2.6 1.5 1 0 0 1 1 1 1 GXGXG motif Pyr_redox_2 PF07992.14 EDO17051.1 - 2.7e-23 82.6 0.3 3.3e-22 79.1 0.3 2.4 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Fer4_20 PF14691.6 EDO17051.1 - 3.1e-23 81.7 0.1 5.9e-23 80.8 0.1 1.5 1 0 0 1 1 1 1 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster NAD_binding_8 PF13450.6 EDO17051.1 - 5.8e-09 36.1 0.0 1.6e-08 34.7 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 EDO17051.1 - 2.4e-08 34.4 0.2 3.5e-05 24.3 0.1 3.3 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EDO17051.1 - 3.1e-06 26.7 4.9 0.0015 17.9 0.1 3.2 2 1 1 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 EDO17051.1 - 4.6e-06 26.2 0.0 1.2e-05 24.8 0.0 1.7 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase HI0933_like PF03486.14 EDO17051.1 - 2.9e-05 23.0 1.2 5.7e-05 22.0 0.1 2.0 2 0 0 2 2 2 1 HI0933-like protein DAO PF01266.24 EDO17051.1 - 0.00033 20.4 0.2 0.00098 18.8 0.1 1.8 2 0 0 2 2 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EDO17051.1 - 0.00034 19.8 0.1 0.00063 18.9 0.1 1.4 1 0 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.7 EDO17051.1 - 0.0013 18.2 1.5 0.0021 17.5 0.1 1.9 1 1 1 2 2 2 1 FAD dependent oxidoreductase NAD_binding_7 PF13241.6 EDO17051.1 - 0.0055 17.1 0.2 3 8.3 0.0 3.1 3 0 0 3 3 2 1 Putative NAD(P)-binding Thi4 PF01946.17 EDO17051.1 - 0.0064 15.8 0.0 0.02 14.1 0.0 1.8 1 0 0 1 1 1 1 Thi4 family FAD_binding_3 PF01494.19 EDO17051.1 - 0.011 15.0 0.0 0.021 14.1 0.0 1.4 1 0 0 1 1 1 0 FAD binding domain NAD_Gly3P_dh_N PF01210.23 EDO17051.1 - 0.02 14.8 0.0 0.065 13.2 0.0 1.9 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus GIDA PF01134.22 EDO17051.1 - 0.022 13.9 1.6 0.12 11.5 0.0 2.5 3 0 0 3 3 3 0 Glucose inhibited division protein A F420_oxidored PF03807.17 EDO17051.1 - 0.034 14.7 0.0 0.64 10.6 0.0 2.9 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent GATase_6 PF13522.6 EDO17051.1 - 0.036 14.3 0.0 0.14 12.3 0.0 2.0 1 0 0 1 1 1 0 Glutamine amidotransferase domain 2-Hacid_dh_C PF02826.19 EDO17051.1 - 0.052 12.9 0.0 3.5 6.9 0.0 2.5 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ApbA PF02558.16 EDO17051.1 - 0.065 12.9 0.1 0.24 11.0 0.1 2.0 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA AlaDh_PNT_C PF01262.21 EDO17051.1 - 0.066 12.5 0.0 10 5.3 0.0 2.4 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain IlvN PF07991.12 EDO17051.1 - 0.074 12.6 0.9 0.88 9.1 0.0 2.8 3 0 0 3 3 3 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain FMN_dh PF01070.18 EDO17051.1 - 0.12 11.4 0.6 0.54 9.2 0.7 1.9 2 0 0 2 2 2 0 FMN-dependent dehydrogenase Lycopene_cycl PF05834.12 EDO17051.1 - 0.13 11.3 0.1 0.25 10.4 0.1 1.4 1 0 0 1 1 1 0 Lycopene cyclase protein 3HCDH_N PF02737.18 EDO17051.1 - 0.17 11.8 0.1 0.43 10.4 0.1 1.8 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain SCF PF02404.15 EDO17051.1 - 0.19 11.0 1.4 0.42 9.9 1.4 1.5 1 0 0 1 1 1 0 Stem cell factor AdoHcyase_NAD PF00670.21 EDO17051.1 - 1.8 8.6 9.2 23 5.0 0.8 3.9 4 1 1 5 5 3 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain PRELI PF04707.14 EDO17052.1 - 2.9e-43 147.4 0.3 3.4e-43 147.2 0.3 1.0 1 0 0 1 1 1 1 PRELI-like family NMT_C PF02799.15 EDO17054.1 - 1e-78 263.7 0.7 1.4e-78 263.2 0.7 1.2 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain NMT PF01233.19 EDO17054.1 - 1.2e-73 246.3 0.5 2.1e-73 245.4 0.1 1.7 2 0 0 2 2 2 1 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain Acetyltransf_9 PF13527.7 EDO17054.1 - 0.0015 18.6 0.0 0.02 15.0 0.0 2.2 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EDO17054.1 - 0.022 15.0 0.0 0.049 13.9 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family WD40 PF00400.32 EDO17055.1 - 2.2e-05 25.1 9.6 0.0064 17.3 1.1 5.3 6 0 0 6 6 6 1 WD domain, G-beta repeat Nup160 PF11715.8 EDO17055.1 - 4.2e-05 22.4 2.0 0.0016 17.2 0.7 2.3 1 1 1 2 2 2 2 Nucleoporin Nup120/160 PQQ_3 PF13570.6 EDO17055.1 - 0.023 15.2 0.1 0.18 12.3 0.0 2.6 4 0 0 4 4 4 0 PQQ-like domain Frankia_peptide PF14407.6 EDO17055.1 - 0.05 13.6 1.9 0.11 12.4 0.7 2.1 2 0 0 2 2 2 0 Ribosomally synthesized peptide prototyped by Frankia Franean1_4349. SUKH_6 PF14568.6 EDO17055.1 - 0.084 13.3 0.0 0.084 13.3 0.0 2.6 3 1 0 3 3 3 0 SMI1-KNR4 cell-wall Kelch_5 PF13854.6 EDO17055.1 - 0.18 11.8 0.5 24 5.1 0.0 3.0 2 0 0 2 2 2 0 Kelch motif Nop PF01798.18 EDO17057.1 - 2e-84 282.6 0.1 2e-84 282.6 0.1 1.7 2 0 0 2 2 2 1 snoRNA binding domain, fibrillarin NOP5NT PF08156.13 EDO17057.1 - 6.9e-20 71.2 0.3 6.9e-20 71.2 0.3 2.4 2 0 0 2 2 2 1 NOP5NT (NUC127) domain MCM_bind PF09739.9 EDO17057.1 - 0.1 11.1 16.2 0.14 10.6 16.2 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor RNA_polI_A34 PF08208.11 EDO17057.1 - 0.2 11.7 45.9 0.32 11.1 45.9 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 GAGA_bind PF06217.12 EDO17057.1 - 0.73 10.1 15.9 1.2 9.4 15.9 1.3 1 0 0 1 1 1 0 GAGA binding protein-like family RRN3 PF05327.11 EDO17057.1 - 0.95 7.9 9.9 1.3 7.5 9.9 1.3 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 RR_TM4-6 PF06459.12 EDO17057.1 - 1.2 8.9 23.2 1.8 8.3 23.2 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 POC1 PF10450.9 EDO17058.1 - 5.5e-156 517.5 2.0 6.2e-156 517.3 2.0 1.0 1 0 0 1 1 1 1 POC1 chaperone Prefoldin_2 PF01920.20 EDO17059.1 - 1.3e-26 92.6 9.5 1.5e-26 92.4 9.5 1.0 1 0 0 1 1 1 1 Prefoldin subunit Sec2p PF06428.11 EDO17059.1 - 0.0048 16.8 7.0 0.023 14.6 0.6 2.2 2 0 0 2 2 2 1 GDP/GTP exchange factor Sec2p Med4 PF10018.9 EDO17059.1 - 0.014 15.0 0.7 0.014 15.0 0.7 1.9 2 0 0 2 2 2 0 Vitamin-D-receptor interacting Mediator subunit 4 DUF4201 PF13870.6 EDO17059.1 - 0.034 13.9 1.3 0.034 13.9 1.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4201) Uso1_p115_C PF04871.13 EDO17059.1 - 0.072 13.5 7.0 2.2 8.6 0.6 2.0 2 0 0 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region MetOD2 PF18548.1 EDO17059.1 - 0.091 12.9 3.6 0.097 12.8 2.7 1.6 1 1 0 1 1 1 0 Metanogen output domain 2 Spc24 PF08286.11 EDO17059.1 - 0.099 12.9 8.4 1.7 8.9 1.4 2.1 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 DUF641 PF04859.12 EDO17059.1 - 0.11 12.8 6.4 0.5 10.7 6.4 1.9 1 1 0 1 1 1 0 Plant protein of unknown function (DUF641) DUF5082 PF16888.5 EDO17059.1 - 0.2 11.9 6.4 1.3 9.3 6.4 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF5082) Bcr-Abl_Oligo PF09036.10 EDO17059.1 - 0.27 11.2 7.0 0.55 10.3 1.2 2.2 2 0 0 2 2 2 0 Bcr-Abl oncoprotein oligomerisation domain YojJ PF10372.9 EDO17059.1 - 0.32 11.1 4.0 3.6 7.7 0.4 2.5 2 1 0 2 2 2 0 Bacterial membrane-spanning protein N-terminus ATG16 PF08614.11 EDO17059.1 - 0.33 11.1 7.2 1.4 9.1 0.8 2.0 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) CC2-LZ PF16516.5 EDO17059.1 - 0.36 11.2 7.1 0.2 12.1 0.6 2.4 2 1 0 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator UPF0242 PF06785.11 EDO17059.1 - 0.7 10.0 8.9 0.85 9.7 8.9 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Med9 PF07544.13 EDO17059.1 - 0.83 9.8 7.3 0.23 11.6 1.4 2.1 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 Prefoldin PF02996.17 EDO17059.1 - 0.92 9.4 9.1 0.22 11.5 1.9 2.1 1 1 0 2 2 2 0 Prefoldin subunit FmiP_Thoc5 PF09766.9 EDO17059.1 - 0.97 8.7 9.0 1.4 8.2 7.3 1.8 1 1 1 2 2 2 0 Fms-interacting protein/Thoc5 ABC_tran_CTD PF16326.5 EDO17059.1 - 1.1 9.6 10.8 1.3 9.3 2.6 2.8 2 1 0 2 2 2 0 ABC transporter C-terminal domain eIF-4B PF06273.11 EDO17059.1 - 1.3 8.0 5.1 1.7 7.6 5.1 1.1 1 0 0 1 1 1 0 Plant specific eukaryotic initiation factor 4B OmpH PF03938.14 EDO17059.1 - 1.5 9.2 10.5 1.1e+02 3.1 10.8 2.1 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) DMPK_coil PF08826.10 EDO17059.1 - 1.6 8.9 9.8 0.23 11.6 2.1 2.4 2 1 0 2 2 2 0 DMPK coiled coil domain like NuA4 PF09340.10 EDO17059.1 - 1.7 8.6 6.1 6.4 6.7 0.7 2.2 1 1 1 2 2 2 0 Histone acetyltransferase subunit NuA4 FlaC_arch PF05377.11 EDO17059.1 - 8.7 6.8 9.7 3.1 8.3 1.7 2.5 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) COQ9 PF08511.11 EDO17060.1 - 5.2e-22 77.4 0.2 9.8e-22 76.5 0.2 1.5 1 0 0 1 1 1 1 COQ9 Dis3l2_C_term PF17877.1 EDO17060.1 - 0.057 13.8 0.0 0.1 12.9 0.0 1.4 1 0 0 1 1 1 0 DIS3-like exonuclease 2 C terminal ADH_N PF08240.12 EDO17061.1 - 5.6e-24 84.1 2.9 5.6e-24 84.1 2.9 1.9 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EDO17061.1 - 4.1e-21 75.3 0.1 1e-20 74.0 0.1 1.7 1 0 0 1 1 1 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 EDO17061.1 - 5.4e-05 22.6 0.1 9.1e-05 21.9 0.1 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.21 EDO17061.1 - 0.00069 19.0 0.5 0.0012 18.1 0.5 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Sacchrp_dh_NADP PF03435.18 EDO17061.1 - 0.0032 17.7 0.0 0.0072 16.6 0.0 1.6 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain UDPG_MGDP_dh_N PF03721.14 EDO17061.1 - 0.014 15.0 0.1 0.025 14.2 0.1 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain TrkA_N PF02254.18 EDO17061.1 - 0.015 15.5 0.0 0.034 14.4 0.0 1.6 1 0 0 1 1 1 0 TrkA-N domain ADH_zinc_N_2 PF13602.6 EDO17061.1 - 0.045 14.8 0.0 0.092 13.8 0.0 1.5 1 0 0 1 1 1 0 Zinc-binding dehydrogenase HycI PF01750.18 EDO17061.1 - 0.053 13.3 0.0 0.092 12.6 0.0 1.3 1 0 0 1 1 1 0 Hydrogenase maturation protease NAD_binding_7 PF13241.6 EDO17061.1 - 0.071 13.6 0.1 0.14 12.6 0.1 1.5 1 0 0 1 1 1 0 Putative NAD(P)-binding zf-RanBP PF00641.18 EDO17062.1 - 3.1e-20 71.2 10.4 2.2e-11 42.9 1.4 2.8 2 0 0 2 2 2 2 Zn-finger in Ran binding protein and others RRM_1 PF00076.22 EDO17062.1 - 4.6e-09 36.0 0.0 0.00013 21.7 0.0 2.8 1 1 1 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) KI67R PF08065.12 EDO17062.1 - 0.22 12.1 2.2 0.89 10.1 0.3 2.8 2 1 1 3 3 3 0 KI67R (NUC007) repeat NCD3G PF07562.14 EDO17062.1 - 8 6.5 8.0 16 5.6 0.6 2.5 2 0 0 2 2 2 0 Nine Cysteines Domain of family 3 GPCR DZR PF12773.7 EDO17062.1 - 9.2 6.4 8.2 27 4.9 1.5 2.5 2 0 0 2 2 2 0 Double zinc ribbon AAA_18 PF13238.6 EDO17063.1 - 2.9e-31 108.7 0.3 5e-31 107.9 0.1 1.5 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.6 EDO17063.1 - 9.1e-07 29.4 0.0 4.1e-06 27.3 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EDO17063.1 - 0.00015 22.0 0.0 0.00042 20.6 0.0 1.8 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 EDO17063.1 - 0.00024 21.4 0.1 0.00076 19.8 0.0 1.8 2 0 0 2 2 2 1 RNA helicase AAA_16 PF13191.6 EDO17063.1 - 0.00027 21.4 0.0 0.00046 20.6 0.0 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_28 PF13521.6 EDO17063.1 - 0.00036 20.8 0.0 0.0016 18.7 0.0 2.0 2 1 0 2 2 2 1 AAA domain Rad17 PF03215.15 EDO17063.1 - 0.00044 20.2 0.0 0.00085 19.3 0.0 1.5 1 0 0 1 1 1 1 Rad17 P-loop domain Thymidylate_kin PF02223.17 EDO17063.1 - 0.0011 18.6 0.1 0.86 9.2 0.0 2.2 2 0 0 2 2 2 2 Thymidylate kinase ADK PF00406.22 EDO17063.1 - 0.0031 17.6 0.1 0.54 10.4 0.0 2.3 2 1 0 2 2 2 1 Adenylate kinase AAA PF00004.29 EDO17063.1 - 0.0095 16.4 0.0 0.018 15.5 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ABC_tran PF00005.27 EDO17063.1 - 0.012 16.1 0.4 0.088 13.3 0.4 2.0 1 1 0 1 1 1 0 ABC transporter KTI12 PF08433.10 EDO17063.1 - 0.016 14.7 0.0 0.049 13.1 0.0 1.7 2 0 0 2 2 2 0 Chromatin associated protein KTI12 AAA_14 PF13173.6 EDO17063.1 - 0.017 15.1 0.0 0.051 13.6 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.14 EDO17063.1 - 0.021 14.8 0.0 0.034 14.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) NTPase_1 PF03266.15 EDO17063.1 - 0.021 14.7 0.0 0.064 13.2 0.0 1.8 2 1 0 2 2 2 0 NTPase AAA_33 PF13671.6 EDO17063.1 - 0.027 14.6 0.1 1.5 9.0 0.1 2.5 1 1 0 1 1 1 0 AAA domain Viral_helicase1 PF01443.18 EDO17063.1 - 0.029 14.1 0.0 0.043 13.5 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase DUF4420 PF14390.6 EDO17063.1 - 0.036 13.3 0.1 0.051 12.8 0.1 1.2 1 0 0 1 1 1 0 Putative PD-(D/E)XK family member, (DUF4420) Zeta_toxin PF06414.12 EDO17063.1 - 0.086 12.1 0.0 0.17 11.2 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin Mg_chelatase PF01078.21 EDO17063.1 - 0.09 12.1 0.0 0.13 11.6 0.0 1.2 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_29 PF13555.6 EDO17063.1 - 0.16 11.8 0.0 0.36 10.6 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain NOT2_3_5 PF04153.18 EDO17064.1 - 2.2e-30 105.4 1.3 3e-30 105.0 1.3 1.2 1 0 0 1 1 1 1 NOT2 / NOT3 / NOT5 family zf-Mss51 PF13824.6 EDO17065.1 - 1.1e-15 57.5 1.7 1.9e-15 56.7 1.7 1.4 1 0 0 1 1 1 1 Zinc-finger of mitochondrial splicing suppressor 51 YL1_C PF08265.11 EDO17065.1 - 0.056 13.2 0.1 0.12 12.2 0.1 1.6 1 0 0 1 1 1 0 YL1 nuclear protein C-terminal domain Heme_oxygenase PF01126.20 EDO17066.1 - 8.8e-14 51.8 0.8 7.8e-13 48.7 0.8 2.1 1 1 0 1 1 1 1 Heme oxygenase CENP-X PF09415.10 EDO17067.1 - 2.4e-23 82.2 1.8 2.7e-23 82.1 1.8 1.0 1 0 0 1 1 1 1 CENP-S associating Centromere protein X CBFD_NFYB_HMF PF00808.23 EDO17067.1 - 0.036 14.3 0.0 0.09 13.1 0.0 1.7 1 1 1 2 2 2 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Sel1 PF08238.12 EDO17068.1 - 4.4e-19 68.5 12.0 0.0013 19.3 0.0 7.0 7 0 0 7 7 7 4 Sel1 repeat TPR_1 PF00515.28 EDO17068.1 - 2.8e-08 33.2 3.6 0.036 13.9 0.0 4.9 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 EDO17068.1 - 5.8e-05 22.9 7.0 0.29 11.4 0.1 5.5 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 EDO17068.1 - 0.00023 21.1 2.5 2.4 8.6 0.1 5.0 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 EDO17068.1 - 0.00031 21.3 0.2 0.00031 21.3 0.2 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.6 EDO17068.1 - 0.00071 19.2 6.1 0.0015 18.2 0.1 4.4 4 1 0 4 4 4 1 TPR repeat TPR_6 PF13174.6 EDO17068.1 - 0.0028 18.2 11.6 0.62 10.8 0.1 5.8 5 1 0 5 5 5 1 Tetratricopeptide repeat TPR_12 PF13424.6 EDO17068.1 - 0.0031 17.8 5.7 1.2 9.4 0.0 5.0 5 1 1 6 6 6 3 Tetratricopeptide repeat TPR_7 PF13176.6 EDO17068.1 - 0.0047 16.9 6.8 0.66 10.1 0.0 5.5 6 0 0 6 6 6 1 Tetratricopeptide repeat Guanylate_cyc PF00211.20 EDO17068.1 - 0.17 11.5 0.0 0.3 10.7 0.0 1.3 1 0 0 1 1 1 0 Adenylate and Guanylate cyclase catalytic domain WD40 PF00400.32 EDO17069.1 - 3.3e-19 68.9 19.6 0.00013 22.7 0.3 6.6 6 1 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDO17069.1 - 1e-06 28.9 6.0 0.049 13.9 0.1 4.8 2 2 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain TFIIIC_delta PF12657.7 EDO17069.1 - 0.034 14.1 4.3 0.16 11.9 4.3 2.2 1 1 0 1 1 1 0 Transcription factor IIIC subunit delta N-term DUF4822 PF16103.5 EDO17069.1 - 0.045 14.0 0.1 0.087 13.1 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4822) PNP_UDP_1 PF01048.20 EDO17070.1 - 2.3e-46 157.9 0.0 2.8e-46 157.7 0.0 1.1 1 0 0 1 1 1 1 Phosphorylase superfamily Pkinase PF00069.25 EDO17071.1 - 6e-69 232.3 0.0 1e-68 231.6 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO17071.1 - 4.1e-40 137.7 0.0 7.4e-40 136.9 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EDO17071.1 - 3.8e-08 32.7 6.9 3.8e-08 32.7 6.9 2.0 2 1 0 2 2 2 1 Haspin like kinase domain Kinase-like PF14531.6 EDO17071.1 - 0.00022 20.6 0.0 0.00045 19.6 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EDO17071.1 - 0.00052 18.9 0.0 0.00052 18.9 0.0 2.0 3 0 0 3 3 3 1 Fungal protein kinase WD40 PF00400.32 EDO17073.1 - 3e-09 37.3 5.1 0.017 16.0 0.0 5.4 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDO17073.1 - 0.0016 18.7 0.0 5.9 7.3 0.0 3.3 2 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain CBS PF00571.28 EDO17074.1 - 8.2e-21 74.2 1.3 2.9e-05 24.4 0.0 5.3 5 0 0 5 5 5 5 CBS domain NAD_binding_7 PF13241.6 EDO17075.1 - 3e-25 88.7 0.0 5.9e-25 87.7 0.0 1.5 1 0 0 1 1 1 1 Putative NAD(P)-binding Sirohm_synth_C PF14823.6 EDO17075.1 - 4.9e-18 64.5 0.2 9.6e-18 63.6 0.2 1.5 1 0 0 1 1 1 1 Sirohaem biosynthesis protein C-terminal Sirohm_synth_M PF14824.6 EDO17075.1 - 9.8e-11 40.9 0.1 1.6e-10 40.2 0.1 1.4 1 0 0 1 1 1 1 Sirohaem biosynthesis protein central Shikimate_DH PF01488.20 EDO17075.1 - 0.013 15.5 0.0 0.037 14.1 0.0 1.7 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase DUF1425 PF07233.12 EDO17075.1 - 0.051 13.5 0.0 0.099 12.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1425) RRM_1 PF00076.22 EDO17076.1 - 2.1e-44 149.2 0.0 3.2e-17 62.1 0.0 4.4 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EDO17076.1 - 2.8e-07 30.3 0.0 7.1e-06 25.8 0.0 2.6 2 0 0 2 2 2 1 Occluded RNA-recognition motif Nup35_RRM_2 PF14605.6 EDO17076.1 - 5.2e-06 26.4 0.0 2.3e-05 24.3 0.0 2.1 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.11 EDO17076.1 - 0.0011 19.0 0.0 0.019 15.0 0.0 2.8 3 0 0 3 3 3 1 RNA binding motif RRM_7 PF16367.5 EDO17076.1 - 0.0022 18.0 0.0 0.022 14.9 0.0 2.6 3 0 0 3 3 3 1 RNA recognition motif Cornichon PF03311.14 EDO17077.1 - 9.8e-47 158.3 11.0 1.1e-46 158.1 11.0 1.0 1 0 0 1 1 1 1 Cornichon protein Sm_multidrug_ex PF06695.11 EDO17077.1 - 0.098 13.3 0.9 0.17 12.5 0.9 1.4 1 0 0 1 1 1 0 Putative small multi-drug export protein HRI1 PF16815.5 EDO17078.1 - 5.1e-42 144.1 0.7 5.7e-42 144.0 0.7 1.0 1 0 0 1 1 1 1 Protein HRI1 Cellulase PF00150.18 EDO17079.1 - 2.2e-12 47.0 0.6 7.3e-12 45.3 0.1 1.9 2 0 0 2 2 2 1 Cellulase (glycosyl hydrolase family 5) DUF1708 PF08101.11 EDO17080.1 - 2.2e-143 478.5 15.8 2.2e-143 478.5 15.8 2.6 2 1 0 2 2 2 1 Domain of unknown function (DUF1708) DUF5501 PF17605.2 EDO17080.1 - 6.6 7.2 7.6 2.6 8.5 0.8 2.9 2 0 0 2 2 2 0 Family of unknown function (DUF5501) TAL_FSA PF00923.19 EDO17081.1 - 8.9e-98 327.2 0.1 1.1e-97 326.9 0.1 1.0 1 0 0 1 1 1 1 Transaldolase/Fructose-6-phosphate aldolase tRNA_deacylase PF04414.12 EDO17082.1 - 0.064 12.8 0.2 0.42 10.1 0.0 2.1 2 0 0 2 2 2 0 D-aminoacyl-tRNA deacylase SNF2_N PF00176.23 EDO17083.1 - 9.9e-63 212.0 0.1 1.7e-62 211.2 0.1 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Cdh1_DBD_1 PF18196.1 EDO17083.1 - 4.6e-44 149.6 2.4 4.6e-44 149.6 2.4 3.4 3 1 1 4 4 4 1 Chromodomain helicase DNA-binding domain 1 DUF4208 PF13907.6 EDO17083.1 - 2.9e-28 98.2 1.1 2.9e-28 98.2 1.1 3.4 4 0 0 4 4 4 1 Domain of unknown function (DUF4208) Chromo PF00385.24 EDO17083.1 - 3.8e-22 77.9 1.8 1.3e-13 50.6 0.1 3.2 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain Helicase_C PF00271.31 EDO17083.1 - 7.5e-20 71.3 0.0 2.4e-19 69.7 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDO17083.1 - 3.3e-08 33.7 0.0 3.3e-08 33.7 0.0 2.8 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit Myb_DNA-binding PF00249.31 EDO17083.1 - 0.00019 21.6 0.5 0.00089 19.4 0.1 2.4 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EDO17083.1 - 0.024 14.9 0.3 0.12 12.6 0.0 2.4 2 0 0 2 2 2 0 Myb-like DNA-binding domain SLIDE PF09111.10 EDO17083.1 - 0.074 13.1 0.0 0.074 13.1 0.0 3.0 3 1 1 4 4 4 0 SLIDE ChaC PF04752.12 EDO17084.1 - 4.3e-56 189.8 0.0 5.2e-56 189.5 0.0 1.1 1 0 0 1 1 1 1 ChaC-like protein Rad4 PF03835.15 EDO17085.1 - 8.6e-33 113.1 2.7 8.6e-33 113.1 2.7 2.4 2 0 0 2 2 2 1 Rad4 transglutaminase-like domain BHD_3 PF10405.9 EDO17085.1 - 5e-22 78.1 0.7 9.7e-22 77.2 0.7 1.5 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 3 BHD_1 PF10403.9 EDO17085.1 - 3.7e-17 61.9 0.0 9e-17 60.7 0.0 1.7 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 1 Transglut_core PF01841.19 EDO17085.1 - 0.00029 21.3 0.1 0.0011 19.4 0.0 2.1 2 0 0 2 2 2 1 Transglutaminase-like superfamily BHD_2 PF10404.9 EDO17085.1 - 0.00087 20.2 1.3 0.00087 20.2 1.3 4.5 5 1 0 5 5 5 1 Rad4 beta-hairpin domain 2 SPT2 PF08243.11 EDO17086.1 - 8.1e-28 97.2 31.8 1.5e-27 96.3 30.8 2.0 1 1 0 1 1 1 1 SPT2 chromatin protein SPX PF03105.19 EDO17087.1 - 1.3e-07 32.0 0.5 1.3e-07 32.0 0.5 4.1 2 2 2 4 4 4 2 SPX domain PGAP1 PF07819.13 EDO17087.1 - 0.026 14.3 0.1 0.076 12.7 0.1 1.7 1 0 0 1 1 1 0 PGAP1-like protein DUF2408 PF10303.9 EDO17087.1 - 1.7 9.2 7.8 1.5 9.4 4.5 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF2408) Hydrolase PF00702.26 EDO17088.1 - 1.5e-06 28.7 0.0 2.2e-06 28.1 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EDO17088.1 - 6.7e-06 26.1 0.0 1.6e-05 24.9 0.0 1.6 1 0 0 1 1 1 1 HAD-hyrolase-like DNA_mis_repair PF01119.19 EDO17089.1 - 7.6e-13 48.2 0.3 1.9e-12 46.9 0.3 1.7 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.6 EDO17089.1 - 1.9e-12 47.1 0.4 7.6e-12 45.2 0.4 2.0 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 EDO17089.1 - 9.4e-08 32.6 0.4 2.2e-07 31.4 0.4 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF4129 PF13559.6 EDO17091.1 - 0.099 12.9 0.0 0.22 11.8 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4129) MIF4G_like PF09088.11 EDO17092.1 - 1e-54 185.2 1.3 3.4e-54 183.5 0.8 2.0 2 0 0 2 2 2 1 MIF4G like MIF4G_like_2 PF09090.11 EDO17092.1 - 1.9e-53 181.7 3.3 4.8e-45 154.1 1.4 2.7 3 0 0 3 3 3 2 MIF4G like MIF4G PF02854.19 EDO17092.1 - 7.3e-13 48.6 6.4 7.3e-13 48.6 6.4 2.6 2 2 1 3 3 3 1 MIF4G domain HDOD PF08668.12 EDO17092.1 - 0.034 13.6 0.0 0.072 12.6 0.0 1.5 1 0 0 1 1 1 0 HDOD domain DUF4029 PF13221.6 EDO17092.1 - 2.1 9.1 6.6 7.1 7.4 1.0 3.0 2 1 0 2 2 2 0 Protein of unknown function (DUF4029) zf-C3HC4_3 PF13920.6 EDO17094.1 - 4.7e-09 36.0 11.7 9.3e-09 35.0 11.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Amidase_6 PF12671.7 EDO17094.1 - 0.034 14.3 0.4 0.22 11.6 0.0 2.2 2 0 0 2 2 2 0 Putative amidase domain Prok-RING_4 PF14447.6 EDO17094.1 - 0.25 11.2 12.1 0.53 10.2 12.1 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 TFIIA PF03153.13 EDO17094.1 - 0.45 10.5 7.6 0.74 9.8 7.6 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit BUD22 PF09073.10 EDO17094.1 - 3.6 6.8 8.2 5.3 6.3 8.2 1.2 1 0 0 1 1 1 0 BUD22 SDA1 PF05285.12 EDO17094.1 - 7.3 5.9 10.8 9.8 5.5 10.8 1.2 1 0 0 1 1 1 0 SDA1 Tom22 PF04281.13 EDO17094.1 - 9.8 6.0 9.3 0.88 9.4 4.4 1.8 2 0 0 2 2 2 0 Mitochondrial import receptor subunit Tom22 AICARFT_IMPCHas PF01808.18 EDO17095.1 - 9.2e-93 310.9 0.0 1.4e-92 310.3 0.0 1.3 1 0 0 1 1 1 1 AICARFT/IMPCHase bienzyme MGS PF02142.22 EDO17095.1 - 1.9e-24 85.7 0.6 3.7e-24 84.7 0.0 1.8 2 0 0 2 2 2 1 MGS-like domain Ribosomal_L15e PF00827.17 EDO17096.1 - 7.7e-89 296.5 13.0 9.5e-89 296.2 13.0 1.0 1 0 0 1 1 1 1 Ribosomal L15 Aminotran_1_2 PF00155.21 EDO17098.1 - 2.9e-76 257.0 0.0 3.3e-76 256.8 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II NAR2 PF16974.5 EDO17098.1 - 0.02 14.3 0.0 0.043 13.2 0.0 1.4 1 0 0 1 1 1 0 High-affinity nitrate transporter accessory Ribosomal_L5_C PF00673.21 EDO17099.1 - 4.6e-22 78.0 0.0 6.7e-22 77.5 0.0 1.3 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.19 EDO17099.1 - 2.1e-19 69.6 0.1 5e-19 68.4 0.0 1.7 2 0 0 2 2 2 1 Ribosomal protein L5 HTH_ABP1_N PF18107.1 EDO17099.1 - 0.074 12.8 0.0 0.15 11.8 0.0 1.5 1 0 0 1 1 1 0 Fission yeast centromere protein N-terminal domain BCAS2 PF05700.11 EDO17100.1 - 1.1e-06 28.5 7.9 4.6e-06 26.5 7.9 1.8 1 1 0 1 1 1 1 Breast carcinoma amplified sequence 2 (BCAS2) DUF5452 PF17533.2 EDO17100.1 - 1.7e-05 25.0 5.8 2.4e-05 24.5 5.8 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF5452) DUF4149 PF13664.6 EDO17102.1 - 3.4e-20 72.3 1.2 3.4e-20 72.3 1.2 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4149) MAS20 PF02064.15 EDO17103.1 - 3e-39 134.1 0.1 4e-39 133.7 0.1 1.1 1 0 0 1 1 1 1 MAS20 protein import receptor SLX9 PF15341.6 EDO17104.1 - 9.2e-23 81.1 14.8 9.2e-23 81.1 14.8 1.6 2 0 0 2 2 2 1 Ribosome biogenesis protein SLX9 DUF3818 PF12825.7 EDO17105.1 - 1.1e-109 366.5 8.0 4.4e-109 364.6 8.0 2.1 1 0 0 1 1 1 1 Domain of unknown function in PX-proteins (DUF3818) PXB PF12828.7 EDO17105.1 - 6e-37 126.5 4.7 1.5e-36 125.3 4.4 1.9 2 0 0 2 2 2 1 PX-associated PX PF00787.24 EDO17105.1 - 9.7e-10 38.4 2.6 3.1e-09 36.8 0.3 3.0 3 0 0 3 3 3 1 PX domain Homeodomain PF00046.29 EDO17105.1 - 0.26 11.2 2.4 14 5.6 0.1 3.0 2 0 0 2 2 2 0 Homeodomain MAGE_N PF12440.8 EDO17105.1 - 0.51 11.0 3.0 1.5 9.5 3.0 1.7 1 0 0 1 1 1 0 Melanoma associated antigen family N terminal PALP PF00291.25 EDO17107.1 - 3.6e-62 210.4 0.0 4.2e-62 210.2 0.0 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme CTP_transf_like PF01467.26 EDO17108.1 - 5.1e-32 111.0 0.0 8.3e-32 110.3 0.0 1.3 1 0 0 1 1 1 1 Cytidylyltransferase-like AvrM_N PF18247.1 EDO17108.1 - 0.11 12.5 0.0 0.38 10.7 0.0 1.9 2 0 0 2 2 2 0 Flax-rust effector AvrM N-terminal domain DUF4112 PF13430.6 EDO17109.1 - 7.2e-29 100.1 0.3 1e-28 99.6 0.3 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4112) Hid1 PF12722.7 EDO17109.1 - 2.6 6.0 20.1 4 5.5 20.1 1.3 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Pex24p PF06398.11 EDO17110.1 - 2.4e-96 322.9 10.0 3.5e-96 322.4 10.0 1.2 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin zf-CCCH PF00642.24 EDO17111.1 - 1.2e-09 37.8 3.2 1.2e-09 37.8 3.2 1.7 2 0 0 2 2 2 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-C3HC4_3 PF13920.6 EDO17111.1 - 2.2e-09 37.0 6.5 4.6e-09 36.0 6.5 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EDO17111.1 - 3.2e-08 33.3 9.8 7.4e-08 32.1 9.8 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EDO17111.1 - 5.4e-07 29.4 6.3 1e-06 28.5 6.3 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 EDO17111.1 - 8e-07 28.9 10.7 1.5e-06 28.1 10.7 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf_CCCH_4 PF18345.1 EDO17111.1 - 3.6e-06 26.8 5.6 1.1e-05 25.3 5.6 1.9 1 0 0 1 1 1 1 Zinc finger domain zf-C3HC4 PF00097.25 EDO17111.1 - 4.2e-06 26.5 10.9 8.7e-06 25.5 10.9 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EDO17111.1 - 5.2e-06 26.7 8.7 1.1e-05 25.7 8.7 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 EDO17111.1 - 6.9e-06 26.0 8.2 1.6e-05 24.8 8.2 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-CCCH_4 PF18044.1 EDO17111.1 - 0.00048 19.9 1.8 0.00048 19.9 1.8 1.8 2 0 0 2 2 1 1 CCCH-type zinc finger zf-RING_10 PF16685.5 EDO17111.1 - 0.0013 18.9 6.8 0.0015 18.6 5.3 1.9 2 0 0 2 2 2 1 zinc RING finger of MSL2 zf-C3HC4_4 PF15227.6 EDO17111.1 - 0.0025 17.9 8.0 0.0025 17.9 8.0 1.8 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-rbx1 PF12678.7 EDO17111.1 - 0.012 15.9 3.5 0.03 14.6 3.5 1.7 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_6 PF14835.6 EDO17111.1 - 0.02 14.8 4.4 0.045 13.6 4.4 1.5 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-P11 PF03854.14 EDO17111.1 - 0.22 11.2 7.7 0.57 9.9 7.7 1.6 1 1 0 1 1 1 0 P-11 zinc finger zf-RING_11 PF17123.5 EDO17111.1 - 6 6.7 9.2 4.2 7.2 5.5 2.4 2 0 0 2 2 2 0 RING-like zinc finger Mus7 PF09462.10 EDO17112.1 - 4.4e-14 52.3 8.6 4.4e-14 52.3 8.6 2.7 2 1 1 3 3 3 2 Mus7/MMS22 family MOR2-PAG1_C PF14225.6 EDO17112.1 - 0.019 14.8 2.1 0.29 11.0 0.4 2.4 2 0 0 2 2 2 0 Cell morphogenesis C-terminal dCMP_cyt_deam_1 PF00383.23 EDO17113.1 - 6.7e-09 35.5 0.0 1.1e-08 34.9 0.0 1.3 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 EDO17113.1 - 3e-05 23.8 1.0 5.2e-05 23.0 1.0 1.6 1 1 0 1 1 1 1 MafB19-like deaminase EF1_GNE PF00736.19 EDO17114.1 - 2.1e-32 111.1 1.5 2.1e-32 111.1 1.5 1.7 2 0 0 2 2 2 1 EF-1 guanine nucleotide exchange domain EF-1_beta_acid PF10587.9 EDO17114.1 - 5.4e-12 45.9 2.4 5.4e-12 45.9 2.4 3.1 4 0 0 4 4 4 1 Eukaryotic elongation factor 1 beta central acidic region HEPN_SAV_6107 PF18726.1 EDO17114.1 - 0.017 15.6 0.1 0.034 14.7 0.1 1.5 1 0 0 1 1 1 0 SAV_6107-like HEPN GST_C_2 PF13410.6 EDO17114.1 - 0.029 14.4 0.1 0.37 10.8 0.0 2.4 1 1 1 2 2 2 0 Glutathione S-transferase, C-terminal domain DNA_pol3_a_NII PF11490.8 EDO17114.1 - 0.35 10.8 2.4 0.44 10.4 0.1 2.1 2 0 0 2 2 2 0 DNA polymerase III polC-type N-terminus II B-block_TFIIIC PF04182.12 EDO17115.1 - 8.6e-19 67.5 1.5 5e-18 65.0 0.2 2.9 2 0 0 2 2 2 1 B-block binding subunit of TFIIIC PCI PF01399.27 EDO17115.1 - 0.02 15.4 3.7 1.1 9.8 0.3 3.6 2 1 1 3 3 3 0 PCI domain 3Beta_HSD PF01073.19 EDO17116.1 - 1.3e-88 296.7 0.0 1.6e-88 296.4 0.0 1.0 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 EDO17116.1 - 3e-27 95.6 0.0 3.9e-27 95.3 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EDO17116.1 - 8e-16 58.3 0.0 2.3e-15 56.8 0.0 1.7 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 EDO17116.1 - 8.9e-12 44.7 0.0 4.8e-10 39.0 0.0 2.4 1 1 0 1 1 1 1 Male sterility protein NAD_binding_10 PF13460.6 EDO17116.1 - 2.8e-11 43.6 0.0 3.9e-11 43.2 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding RmlD_sub_bind PF04321.17 EDO17116.1 - 1.3e-10 40.9 0.0 1.8e-10 40.4 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 EDO17116.1 - 2e-08 33.8 0.0 3.6e-08 32.9 0.0 1.4 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NmrA PF05368.13 EDO17116.1 - 0.00039 20.1 0.0 0.00058 19.5 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family KR PF08659.10 EDO17116.1 - 0.016 15.2 0.0 0.088 12.7 0.0 2.0 1 1 0 1 1 1 0 KR domain AP_endonuc_2 PF01261.24 EDO17116.1 - 0.024 14.1 0.0 0.037 13.5 0.0 1.2 1 0 0 1 1 1 0 Xylose isomerase-like TIM barrel Rep_fac-A_C PF08646.10 EDO17117.1 - 2e-58 196.3 4.4 6.7e-56 188.1 0.9 3.0 3 0 0 3 3 3 2 Replication factor-A C terminal domain REPA_OB_2 PF16900.5 EDO17117.1 - 8.9e-35 118.5 2.0 5.8e-31 106.3 0.0 4.1 4 0 0 4 4 4 2 Replication protein A OB domain tRNA_anti-codon PF01336.25 EDO17117.1 - 2.5e-18 65.8 0.2 5.3e-08 32.7 0.0 4.4 4 0 0 4 4 4 4 OB-fold nucleic acid binding domain CDC24_OB3 PF17244.2 EDO17117.1 - 8.7e-10 38.7 0.1 2.9e-06 27.2 0.0 3.7 3 1 0 3 3 3 1 Cell division control protein 24, OB domain 3 Rep-A_N PF04057.12 EDO17117.1 - 1.2e-05 25.3 0.1 4.6e-05 23.4 0.0 2.1 2 0 0 2 2 2 1 Replication factor-A protein 1, N-terminal domain DUF223 PF02721.14 EDO17117.1 - 0.063 13.6 0.3 0.61 10.4 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function DUF223 TPP1 PF10341.9 EDO17117.1 - 0.086 12.8 0.0 0.29 11.1 0.0 1.9 1 0 0 1 1 1 0 Shelterin complex subunit, TPP1/ACD DUF4539 PF15072.6 EDO17117.1 - 0.14 12.2 0.0 1.9 8.6 0.0 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4539) E1-E2_ATPase PF00122.20 EDO17118.1 - 4.8e-48 163.1 6.0 1.7e-47 161.3 5.2 2.3 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 EDO17118.1 - 9.2e-19 68.6 0.2 2.4e-18 67.2 0.2 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EDO17118.1 - 9.9e-11 41.2 0.0 2.4e-10 39.9 0.0 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 EDO17118.1 - 0.0021 17.9 0.1 0.0043 16.8 0.1 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EDO17118.1 - 0.013 15.5 0.0 0.025 14.7 0.0 1.4 1 0 0 1 1 1 0 Cation transport ATPase (P-type) O-antigen_lig PF13425.6 EDO17118.1 - 0.098 11.4 5.0 0.2 10.4 5.0 1.4 1 0 0 1 1 1 0 O-antigen ligase like membrane protein SH3_1 PF00018.28 EDO17119.1 - 1.9e-38 129.8 5.7 1e-14 53.9 0.1 4.3 4 0 0 4 4 4 3 SH3 domain SH3_9 PF14604.6 EDO17119.1 - 3.8e-33 113.1 9.9 6.5e-13 48.3 0.2 4.4 5 0 0 5 5 5 3 Variant SH3 domain SHD1 PF03983.12 EDO17119.1 - 5.3e-32 109.5 0.1 9.9e-32 108.6 0.1 1.5 1 0 0 1 1 1 1 SLA1 homology domain 1, SHD1 SH3_2 PF07653.17 EDO17119.1 - 6.1e-29 99.5 0.3 7.3e-10 38.4 0.1 4.7 4 0 0 4 4 4 3 Variant SH3 domain SAM_4 PF18017.1 EDO17119.1 - 4.3e-06 26.6 0.0 9.2e-06 25.5 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 EDO17119.1 - 0.044 14.2 0.0 0.093 13.2 0.0 1.5 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) RNA_pol_Rpb5_C PF01191.19 EDO17119.1 - 0.13 12.1 0.2 3.2 7.7 0.0 2.4 2 0 0 2 2 2 0 RNA polymerase Rpb5, C-terminal domain Aconitase PF00330.20 EDO17120.1 - 2.1e-161 538.0 0.1 2.5e-161 537.8 0.1 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 EDO17120.1 - 2.1e-45 154.2 0.0 4.1e-45 153.3 0.0 1.5 1 0 0 1 1 1 1 Aconitase C-terminal domain HSCB_C PF07743.13 EDO17121.1 - 2.4e-19 69.6 7.5 1.2e-17 64.2 3.3 2.3 2 0 0 2 2 2 2 HSCB C-terminal oligomerisation domain DnaJ PF00226.31 EDO17121.1 - 1.8e-08 34.4 0.6 1.8e-08 34.4 0.6 2.0 2 0 0 2 2 2 1 DnaJ domain DUF1664 PF07889.12 EDO17121.1 - 0.52 10.4 3.1 0.98 9.5 2.4 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Cortex-I_coil PF09304.10 EDO17121.1 - 1.4 9.1 8.5 0.5 10.6 4.0 2.1 1 1 1 2 2 2 0 Cortexillin I, coiled coil CK_II_beta PF01214.18 EDO17122.1 - 4e-70 235.3 0.4 5.8e-70 234.8 0.4 1.2 1 0 0 1 1 1 1 Casein kinase II regulatory subunit DUF2117 PF09890.9 EDO17122.1 - 0.039 13.4 0.2 0.056 12.9 0.2 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2117) DUF1894 PF08979.11 EDO17122.1 - 0.079 13.3 0.0 0.16 12.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1894) CHD5 PF04420.14 EDO17123.1 - 7.5e-47 159.1 0.6 7.5e-47 159.1 0.6 1.6 2 0 0 2 2 2 1 CHD5-like protein CENP-H PF05837.12 EDO17123.1 - 0.0015 18.9 3.7 0.0015 18.9 3.7 1.9 2 0 0 2 2 2 1 Centromere protein H (CENP-H) LPP PF04728.13 EDO17123.1 - 0.37 11.2 2.7 0.66 10.4 0.5 2.2 2 0 0 2 2 2 0 Lipoprotein leucine-zipper Allexi_40kDa PF05549.11 EDO17123.1 - 0.45 10.0 3.3 0.2 11.2 1.2 1.4 2 0 0 2 2 2 0 Allexivirus 40kDa protein FlaC_arch PF05377.11 EDO17123.1 - 1.6 9.2 7.4 2 8.9 0.1 3.1 3 1 1 4 4 4 0 Flagella accessory protein C (FlaC) STT3 PF02516.14 EDO17125.1 - 8.9e-151 503.1 49.1 1.2e-147 492.8 46.6 2.1 2 0 0 2 2 2 2 Oligosaccharyl transferase STT3 subunit FYVE PF01363.21 EDO17126.1 - 3.5e-15 55.9 6.1 7.7e-15 54.8 6.1 1.6 1 0 0 1 1 1 1 FYVE zinc finger Acyltransferase PF01553.21 EDO17127.1 - 4.1e-10 39.4 0.0 3.9e-09 36.2 0.0 2.3 1 1 0 1 1 1 1 Acyltransferase CitMHS PF03600.16 EDO17127.1 - 0.55 9.4 5.7 0.24 10.6 2.5 1.8 2 0 0 2 2 2 0 Citrate transporter Med3 PF11593.8 EDO17129.1 - 9.7e-49 166.6 136.1 3.9e-40 138.3 78.5 3.0 1 1 1 2 2 2 2 Mediator complex subunit 3 fungal Collagen PF01391.18 EDO17129.1 - 0.1 12.4 2.7 0.27 11.0 2.7 1.7 1 0 0 1 1 1 0 Collagen triple helix repeat (20 copies) Trp_syntA PF00290.20 EDO17130.1 - 9.6e-98 326.2 0.1 1.4e-97 325.6 0.1 1.2 1 0 0 1 1 1 1 Tryptophan synthase alpha chain PALP PF00291.25 EDO17130.1 - 2.3e-48 165.1 1.0 4e-48 164.3 1.0 1.4 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Pkinase PF00069.25 EDO17131.1 - 2.9e-45 154.7 0.1 1.6e-43 149.0 0.0 2.6 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO17131.1 - 2.4e-20 72.9 0.0 5e-20 71.9 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDO17131.1 - 0.041 13.2 0.0 0.12 11.7 0.0 1.5 1 1 0 1 1 1 0 Kinase-like CPP1-like PF11833.8 EDO17131.1 - 0.12 12.0 1.1 0.25 11.0 1.1 1.5 1 0 0 1 1 1 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like DBB PF14545.6 EDO17131.1 - 0.12 12.3 1.5 0.84 9.6 0.0 2.6 2 0 0 2 2 2 0 Dof, BCAP, and BANK (DBB) motif, APH PF01636.23 EDO17131.1 - 0.14 12.1 0.0 0.32 10.9 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family TFR_dimer PF04253.15 EDO17132.1 - 6.1e-31 107.0 0.0 1.2e-30 106.1 0.0 1.5 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain Peptidase_M28 PF04389.17 EDO17132.1 - 7.1e-05 22.6 0.0 0.00026 20.8 0.0 1.9 2 0 0 2 2 2 1 Peptidase family M28 DnaJ PF00226.31 EDO17134.1 - 2.1e-18 66.2 1.1 8.6e-18 64.2 1.1 2.1 1 0 0 1 1 1 1 DnaJ domain Sec63 PF02889.16 EDO17134.1 - 2.7e-05 23.5 0.0 0.00015 21.0 0.0 2.1 1 1 1 2 2 2 1 Sec63 Brl domain Val_tRNA-synt_C PF10458.9 EDO17134.1 - 0.0062 16.8 0.2 0.0062 16.8 0.2 1.9 2 0 0 2 2 2 1 Valyl tRNA synthetase tRNA binding arm Sporozoite_P67 PF05642.11 EDO17134.1 - 0.037 12.1 3.2 0.069 11.2 3.2 1.4 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Nop14 PF04147.12 EDO17134.1 - 1.4 7.0 18.7 2.4 6.3 18.7 1.3 1 0 0 1 1 1 0 Nop14-like family Acetyltransf_1 PF00583.25 EDO17135.1 - 8.1e-15 55.1 0.0 1e-14 54.8 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EDO17135.1 - 2.7e-10 40.3 0.0 3.4e-10 39.9 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EDO17135.1 - 4.1e-10 40.0 0.1 5.9e-10 39.4 0.1 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EDO17135.1 - 1.1e-05 25.3 0.0 1.8e-05 24.6 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_4 PF13420.7 EDO17135.1 - 0.0012 19.0 0.4 0.0016 18.6 0.4 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_15 PF17013.5 EDO17135.1 - 0.023 14.2 1.0 0.025 14.0 1.0 1.2 1 0 0 1 1 1 0 Putative acetyl-transferase Ras_bdg_2 PF14847.6 EDO17136.1 - 0.12 12.7 7.8 0.33 11.3 0.6 3.5 2 1 1 3 3 3 0 Ras-binding domain of Byr2 zf-CRD PF17979.1 EDO17136.1 - 0.22 11.6 2.2 0.2 11.8 0.3 1.9 2 1 0 2 2 2 0 Cysteine rich domain with multizinc binding regions Tma16 PF11176.8 EDO17137.1 - 7.2e-49 165.4 7.5 9.2e-49 165.1 7.5 1.1 1 0 0 1 1 1 1 Translation machinery-associated protein 16 adh_short PF00106.25 EDO17140.1 - 7.8e-25 87.5 0.1 4.1e-12 46.0 0.0 3.1 2 1 1 3 3 3 3 short chain dehydrogenase adh_short_C2 PF13561.6 EDO17140.1 - 1.3e-17 64.1 0.0 8.7e-12 45.1 0.0 3.0 2 1 1 3 3 3 3 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EDO17140.1 - 0.00024 21.0 0.0 0.00048 20.1 0.0 1.4 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EDO17140.1 - 0.00098 18.7 0.0 0.0016 18.0 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3HCDH_N PF02737.18 EDO17140.1 - 0.0059 16.5 0.0 0.0091 15.9 0.0 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DUF1776 PF08643.10 EDO17140.1 - 0.014 14.7 0.6 0.21 10.9 0.6 2.2 1 1 0 1 1 1 0 Fungal family of unknown function (DUF1776) GDP_Man_Dehyd PF16363.5 EDO17140.1 - 0.015 14.8 0.6 0.057 12.8 0.6 1.8 1 1 0 1 1 1 0 GDP-mannose 4,6 dehydratase G6PD_N PF00479.22 EDO17140.1 - 0.049 14.3 0.1 0.068 13.8 0.1 1.2 1 0 0 1 1 1 0 Glucose-6-phosphate dehydrogenase, NAD binding domain E2F_CC-MB PF16421.5 EDO17140.1 - 0.19 12.1 1.1 0.46 10.9 0.8 1.8 2 1 0 2 2 2 0 E2F transcription factor CC-MB domain tRNA-synt_1 PF00133.22 EDO17141.1 - 3.1e-40 138.0 0.0 3.1e-31 108.3 0.0 2.8 2 1 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 EDO17141.1 - 8.7e-18 64.2 0.7 1.1e-09 37.6 0.0 3.6 3 0 0 3 3 3 3 tRNA synthetases class I (M) Anticodon_1 PF08264.13 EDO17141.1 - 2.2e-12 47.2 0.1 2.2e-12 47.2 0.1 1.9 2 0 0 2 2 2 1 Anticodon-binding domain of tRNA tRNA-synt_1e PF01406.19 EDO17141.1 - 1.1e-06 28.2 1.7 1.2e-06 28.1 0.0 1.9 2 0 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain Pet20 PF08692.10 EDO17142.1 - 3.1e-13 50.5 2.4 3e-06 28.0 0.1 2.7 2 1 1 3 3 3 2 Mitochondrial protein Pet20 AAA_assoc PF14363.6 EDO17143.1 - 0.41 11.0 2.7 3 8.3 0.7 2.9 1 1 1 2 2 2 0 Domain associated at C-terminal with AAA Glutaredoxin PF00462.24 EDO17144.1 - 0.006 16.8 0.0 0.022 15.0 0.0 1.9 2 0 0 2 2 2 1 Glutaredoxin Asp PF00026.23 EDO17145.1 - 5.9e-103 344.6 0.0 7.2e-103 344.3 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EDO17145.1 - 1.2e-15 58.3 1.1 4.9e-14 53.0 1.1 2.4 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal TAXi_C PF14541.6 EDO17145.1 - 0.0015 18.4 0.0 0.0096 15.7 0.0 2.1 1 1 0 1 1 1 1 Xylanase inhibitor C-terminal gag-asp_proteas PF13975.6 EDO17145.1 - 0.018 15.6 0.0 10 6.8 0.0 2.7 2 1 0 2 2 2 0 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 EDO17145.1 - 0.04 14.6 0.0 9 7.0 0.0 2.9 2 1 0 2 2 2 0 Aspartyl protease Pkinase PF00069.25 EDO17146.1 - 8.9e-78 261.3 0.0 1.7e-77 260.4 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO17146.1 - 1.2e-35 123.0 0.0 2.3e-35 122.1 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase FHA PF00498.26 EDO17146.1 - 8.1e-28 96.6 2.1 8.1e-15 54.9 0.0 3.1 3 0 0 3 3 3 2 FHA domain Yop-YscD_cpl PF16697.5 EDO17146.1 - 1.7e-10 41.0 0.0 1.1e-06 28.8 0.0 2.7 2 0 0 2 2 2 2 Inner membrane component of T3SS, cytoplasmic domain Kinase-like PF14531.6 EDO17146.1 - 2.1e-09 37.1 0.3 6.6e-09 35.5 0.0 2.0 3 0 0 3 3 3 1 Kinase-like APH PF01636.23 EDO17146.1 - 4.8e-06 26.7 0.0 0.015 15.2 0.0 2.5 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 EDO17146.1 - 4.8e-05 22.8 0.0 9.6e-05 21.8 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family FHA_2 PF17913.1 EDO17146.1 - 0.0034 17.6 0.5 5.4 7.3 0.0 3.5 3 0 0 3 3 3 1 FHA domain RIO1 PF01163.22 EDO17146.1 - 0.022 14.3 0.0 0.058 13.0 0.0 1.7 1 0 0 1 1 1 0 RIO1 family DUF1179 PF06678.11 EDO17146.1 - 0.48 10.4 2.7 1 9.4 2.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1179) WD40 PF00400.32 EDO17147.1 - 7.9e-35 118.3 14.8 1.6e-06 28.8 0.4 7.6 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDO17147.1 - 7.6e-07 29.3 0.2 0.27 11.6 0.0 4.0 2 2 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain BBS2_Mid PF14783.6 EDO17147.1 - 0.0089 16.1 0.0 13 5.9 0.0 3.9 4 0 0 4 4 4 1 Ciliary BBSome complex subunit 2, middle region Nup160 PF11715.8 EDO17147.1 - 0.023 13.4 1.3 4.8 5.7 0.0 3.0 1 1 2 3 3 3 0 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 EDO17147.1 - 0.025 13.4 0.1 8.1 5.1 0.0 3.0 1 1 1 2 2 2 0 Nup133 N terminal like Mur_ligase_M PF08245.12 EDO17148.1 - 1.7e-06 28.2 1.2 0.0017 18.4 0.0 3.5 2 1 1 3 3 3 2 Mur ligase middle domain Mur_ligase_C PF02875.21 EDO17148.1 - 0.011 16.0 0.0 0.032 14.5 0.0 1.8 2 0 0 2 2 2 0 Mur ligase family, glutamate ligase domain DicB PF05358.11 EDO17148.1 - 0.12 12.6 0.0 0.37 11.0 0.0 1.9 1 0 0 1 1 1 0 DicB protein Pkinase PF00069.25 EDO17149.1 - 1.2e-67 228.1 0.0 2.3e-67 227.1 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO17149.1 - 2.9e-39 134.9 0.0 4.7e-39 134.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDO17149.1 - 7e-07 28.8 0.0 1.7e-06 27.6 0.0 1.6 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 EDO17149.1 - 0.095 12.6 0.0 0.15 11.9 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family SGT1 PF07093.11 EDO17150.1 - 4.7e-11 41.8 0.9 4.7e-11 41.8 0.9 2.3 2 0 0 2 2 2 1 SGT1 protein DUF4604 PF15377.6 EDO17151.1 - 0.5 10.8 28.6 0.71 10.3 28.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) PBP1_TM PF14812.6 EDO17151.1 - 5.2 7.5 10.9 2.3 8.6 7.9 2.0 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal BUD22 PF09073.10 EDO17151.1 - 8.1 5.7 36.3 9.8 5.4 36.3 1.1 1 0 0 1 1 1 0 BUD22 ACPS PF01648.20 EDO17152.1 - 1.5e-14 54.1 0.0 2.3e-14 53.5 0.0 1.3 1 0 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily Tax PF02959.16 EDO17152.1 - 0.075 12.5 0.0 0.11 12.0 0.0 1.3 1 0 0 1 1 1 0 HTLV Tax DUF1749 PF08538.10 EDO17153.1 - 2.5e-93 312.4 0.1 3e-93 312.2 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1749) Hydrolase_4 PF12146.8 EDO17153.1 - 1.3e-08 34.4 0.0 1.1e-07 31.4 0.0 2.1 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EDO17153.1 - 0.00067 19.4 0.0 0.0056 16.4 0.0 2.1 2 0 0 2 2 2 1 alpha/beta hydrolase fold Chlorophyllase2 PF12740.7 EDO17153.1 - 0.0032 16.4 0.0 0.0051 15.7 0.0 1.2 1 0 0 1 1 1 1 Chlorophyllase enzyme LIDHydrolase PF10230.9 EDO17153.1 - 0.0069 16.0 0.1 0.033 13.7 0.0 1.9 2 0 0 2 2 2 1 Lipid-droplet associated hydrolase Peptidase_S9 PF00326.21 EDO17153.1 - 0.0098 15.4 0.0 0.13 11.7 0.0 2.6 2 1 1 3 3 3 1 Prolyl oligopeptidase family DUF915 PF06028.11 EDO17153.1 - 0.027 13.8 0.0 0.037 13.4 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF915) Chlorophyllase PF07224.11 EDO17153.1 - 0.053 12.5 0.0 0.096 11.7 0.0 1.3 1 0 0 1 1 1 0 Chlorophyllase Abhydrolase_6 PF12697.7 EDO17153.1 - 0.058 14.0 0.0 0.074 13.6 0.0 1.3 1 1 0 1 1 1 0 Alpha/beta hydrolase family GT-D PF08759.11 EDO17154.1 - 0.017 14.8 0.5 1.1 8.9 0.4 2.3 2 0 0 2 2 2 0 Glycosyltransferase GT-D fold Oxysterol_BP PF01237.18 EDO17155.1 - 3.1e-55 187.5 4.0 6.7e-53 179.9 4.0 2.1 1 1 0 1 1 1 1 Oxysterol-binding protein DUF5061 PF16587.5 EDO17155.1 - 0.12 12.4 0.0 0.36 10.9 0.0 1.8 2 0 0 2 2 2 0 17 kDa common-antigen outer membrane protein DHFR_1 PF00186.19 EDO17156.1 - 8.2e-29 100.4 0.0 1.2e-28 99.8 0.0 1.3 1 0 0 1 1 1 1 Dihydrofolate reductase POC3_POC4 PF10448.9 EDO17157.1 - 1.6e-34 118.9 1.9 1.9e-34 118.8 1.9 1.0 1 0 0 1 1 1 1 20S proteasome chaperone assembly proteins 3 and 4 PAC4 PF16093.5 EDO17157.1 - 4.9e-05 23.4 0.0 9.8e-05 22.5 0.0 1.5 1 1 0 1 1 1 1 Proteasome assembly chaperone 4 Ribosomal_L35Ae PF01247.18 EDO17158.1 - 2.2e-42 143.1 0.9 2.4e-42 143.0 0.9 1.0 1 0 0 1 1 1 1 Ribosomal protein L35Ae RimM PF01782.18 EDO17158.1 - 0.0018 18.5 0.0 0.7 10.1 0.0 2.2 2 0 0 2 2 2 2 RimM N-terminal domain Pkinase PF00069.25 EDO17159.1 - 2.5e-66 223.8 0.0 4.6e-66 222.9 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO17159.1 - 3.2e-40 138.0 0.0 5.5e-40 137.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDO17159.1 - 3.1e-08 33.3 0.0 5.8e-08 32.4 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 EDO17159.1 - 0.0021 17.5 0.1 0.033 13.5 0.3 2.6 2 1 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EDO17159.1 - 0.0089 16.0 0.1 0.022 14.7 0.2 1.5 1 1 0 1 1 1 1 Phosphotransferase enzyme family GrpE PF01025.19 EDO17160.1 - 6.6e-49 165.8 7.5 8.5e-49 165.4 7.5 1.1 1 0 0 1 1 1 1 GrpE Uds1 PF15456.6 EDO17160.1 - 0.00031 20.9 0.6 0.00049 20.3 0.6 1.3 1 0 0 1 1 1 1 Up-regulated During Septation PKcGMP_CC PF16808.5 EDO17160.1 - 0.0026 17.6 3.1 0.0063 16.3 3.1 1.6 1 0 0 1 1 1 1 Coiled-coil N-terminus of cGMP-dependent protein kinase TACC_C PF05010.14 EDO17160.1 - 0.0028 17.5 9.3 0.37 10.6 0.2 2.1 2 0 0 2 2 2 2 Transforming acidic coiled-coil-containing protein (TACC), C-terminal OmpH PF03938.14 EDO17160.1 - 0.0075 16.6 5.8 0.012 15.9 5.8 1.3 1 0 0 1 1 1 1 Outer membrane protein (OmpH-like) Nup54 PF13874.6 EDO17160.1 - 0.015 15.4 1.0 0.022 14.9 1.0 1.2 1 0 0 1 1 1 0 Nucleoporin complex subunit 54 IZUMO PF15005.6 EDO17160.1 - 0.1 13.1 2.7 0.17 12.4 2.7 1.3 1 0 0 1 1 1 0 Izumo sperm-egg fusion, Ig domain-associated Syntaxin_2 PF14523.6 EDO17160.1 - 0.16 12.4 8.2 0.37 11.2 8.2 1.6 1 1 0 1 1 1 0 Syntaxin-like protein Pkinase PF00069.25 EDO17161.1 - 9e-72 241.6 0.0 1.2e-71 241.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO17161.1 - 3.8e-36 124.7 0.0 7.3e-36 123.8 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDO17161.1 - 1.7e-08 34.2 0.0 2.9e-08 33.4 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EDO17161.1 - 0.00071 18.5 0.0 0.0013 17.6 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase FTA2 PF13095.6 EDO17161.1 - 0.0014 18.2 0.1 1.1 8.9 0.0 2.3 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 EDO17161.1 - 0.0046 16.3 0.0 0.0074 15.7 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EDO17161.1 - 0.016 15.1 0.0 0.074 13.0 0.0 1.8 1 1 1 2 2 2 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EDO17161.1 - 0.039 12.9 0.0 0.08 11.9 0.0 1.5 1 0 0 1 1 1 0 Haspin like kinase domain Seadorna_VP7 PF07387.11 EDO17161.1 - 0.085 11.9 0.0 0.13 11.3 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 F_actin_cap_B PF01115.17 EDO17161.1 - 0.16 11.5 0.9 0.33 10.5 0.9 1.4 1 0 0 1 1 1 0 F-actin capping protein, beta subunit Synuclein PF01387.17 EDO17162.1 - 0.0045 17.2 0.5 0.015 15.5 0.5 1.9 1 0 0 1 1 1 1 Synuclein NifU_N PF01592.16 EDO17163.1 - 2e-46 157.3 0.4 2.2e-46 157.1 0.4 1.0 1 0 0 1 1 1 1 NifU-like N terminal domain Mito_carr PF00153.27 EDO17164.1 - 8.3e-69 227.6 1.5 5e-26 90.5 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Tim17 PF02466.19 EDO17164.1 - 0.0087 16.4 2.6 0.01 16.2 0.6 2.4 2 1 0 2 2 2 1 Tim17/Tim22/Tim23/Pmp24 family Ribosomal_L5e PF17144.4 EDO17167.1 - 1.3e-83 278.9 0.0 2.2e-83 278.2 0.0 1.4 1 0 0 1 1 1 1 Ribosomal large subunit proteins 60S L5, and 50S L18 Ribosomal_L18_c PF14204.6 EDO17167.1 - 3.2e-30 104.9 0.6 3.2e-30 104.9 0.6 1.8 2 0 0 2 2 2 1 Ribosomal L18 C-terminal region Ribosomal_L18p PF00861.22 EDO17167.1 - 0.0062 16.9 0.3 0.02 15.3 0.0 1.8 2 0 0 2 2 2 1 Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast NAC PF01849.18 EDO17167.1 - 0.046 13.7 0.0 0.088 12.8 0.0 1.4 1 0 0 1 1 1 0 NAC domain Thr_synth_N PF14821.6 EDO17167.1 - 0.078 13.2 0.1 1 9.6 0.0 2.5 2 0 0 2 2 2 0 Threonine synthase N terminus Phage_holin_3_3 PF16083.5 EDO17167.1 - 0.18 12.0 0.0 2.6 8.2 0.0 2.3 2 0 0 2 2 2 0 LydA holin phage, holin superfamily III DPPIV_N PF00930.21 EDO17168.1 - 1.3e-87 293.8 4.6 2e-87 293.2 4.6 1.3 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.21 EDO17168.1 - 1.6e-53 181.4 0.9 2.4e-53 180.8 0.9 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 EDO17168.1 - 0.00044 19.6 0.0 0.21 10.8 0.0 2.2 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Esterase PF00756.20 EDO17168.1 - 0.00096 18.9 0.0 0.0017 18.0 0.0 1.3 1 0 0 1 1 1 1 Putative esterase PAF-AH_p_II PF03403.13 EDO17168.1 - 0.007 14.9 0.0 0.015 13.8 0.0 1.5 2 0 0 2 2 2 1 Platelet-activating factor acetylhydrolase, isoform II Abhydrolase_2 PF02230.16 EDO17168.1 - 0.031 14.1 0.1 1.9 8.3 0.1 2.4 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase ISN1 PF06437.11 EDO17168.1 - 0.044 12.7 0.0 0.078 11.9 0.0 1.3 1 0 0 1 1 1 0 IMP-specific 5'-nucleotidase Abhydrolase_1 PF00561.20 EDO17168.1 - 0.045 13.4 0.0 0.26 10.9 0.0 2.2 1 1 1 2 2 2 0 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EDO17168.1 - 0.11 13.1 0.0 0.76 10.3 0.0 1.9 1 1 1 2 2 2 0 Alpha/beta hydrolase family Peptidase_S15 PF02129.18 EDO17168.1 - 0.6 9.7 7.1 0.12 11.9 0.5 2.6 2 1 1 3 3 3 0 X-Pro dipeptidyl-peptidase (S15 family) YEATS PF03366.16 EDO17170.1 - 5.4e-19 67.9 0.0 8.5e-19 67.3 0.0 1.3 1 0 0 1 1 1 1 YEATS family BET PF17035.5 EDO17170.1 - 4.1e-07 30.1 0.1 7.8e-07 29.2 0.1 1.4 1 0 0 1 1 1 1 Bromodomain extra-terminal - transcription regulation WD40 PF00400.32 EDO17171.1 - 6.6e-31 105.9 18.6 3.9e-05 24.3 0.2 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDO17171.1 - 4e-11 43.0 0.2 0.034 14.4 0.1 5.2 3 2 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EDO17171.1 - 3.4e-05 23.3 0.2 0.037 13.3 0.0 2.4 2 0 0 2 2 2 2 WD40-like domain Nup160 PF11715.8 EDO17171.1 - 0.00075 18.3 2.8 0.0029 16.3 0.4 2.3 2 0 0 2 2 2 1 Nucleoporin Nup120/160 Myotub-related PF06602.14 EDO17171.1 - 0.013 14.5 1.7 0.12 11.3 1.1 2.1 2 0 0 2 2 2 0 Myotubularin-like phosphatase domain Nup88 PF10168.9 EDO17171.1 - 0.31 8.8 3.4 0.31 8.8 1.8 1.7 1 1 1 2 2 2 0 Nuclear pore component TRF PF08558.10 EDO17172.1 - 2.1e-63 214.1 6.0 3.7e-63 213.3 6.0 1.4 1 0 0 1 1 1 1 Telomere repeat binding factor (TRF) Myb_DNA-binding PF00249.31 EDO17172.1 - 4.6e-09 36.3 0.2 3.9e-08 33.3 0.3 2.3 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EDO17172.1 - 6.4e-05 23.1 0.1 0.00025 21.2 0.1 2.1 1 0 0 1 1 1 1 Myb-like DNA-binding domain Linker_histone PF00538.19 EDO17173.1 - 6.5e-42 141.8 1.5 2.6e-21 75.8 0.2 3.7 3 1 1 4 4 4 2 linker histone H1 and H5 family Forkhead PF00250.18 EDO17173.1 - 0.0055 16.9 0.4 0.14 12.4 0.1 2.5 2 0 0 2 2 2 1 Forkhead domain Mucin PF01456.17 EDO17173.1 - 0.049 13.6 20.0 0.082 12.9 20.0 1.3 1 0 0 1 1 1 0 Mucin-like glycoprotein DUF1911 PF08929.10 EDO17173.1 - 0.084 13.7 0.2 3.7 8.4 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1911) Dicty_REP PF05086.12 EDO17173.1 - 0.31 9.0 14.6 0.39 8.6 14.6 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Ndc1_Nup PF09531.10 EDO17173.1 - 0.31 9.7 10.9 0.4 9.3 10.9 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Peptidase_C39_2 PF13529.6 EDO17173.1 - 0.33 11.5 0.1 0.33 11.5 0.1 2.6 2 1 1 3 3 3 0 Peptidase_C39 like family Macoilin PF09726.9 EDO17173.1 - 0.72 8.3 11.1 0.74 8.3 11.1 1.1 1 0 0 1 1 1 0 Macoilin family AJAP1_PANP_C PF15298.6 EDO17173.1 - 3 8.0 13.2 5 7.3 13.2 1.3 1 0 0 1 1 1 0 AJAP1/PANP C-terminus Dynamin_N PF00350.23 EDO17174.1 - 2e-42 145.1 0.3 2e-42 145.1 0.3 3.1 4 0 0 4 4 4 1 Dynamin family MMR_HSR1 PF01926.23 EDO17174.1 - 0.00011 22.3 2.4 0.00034 20.7 0.1 2.9 2 1 0 2 2 2 1 50S ribosome-binding GTPase Dynamin_M PF01031.20 EDO17174.1 - 0.0064 15.7 0.0 0.0064 15.7 0.0 4.1 3 1 0 3 3 3 1 Dynamin central region DUF575 PF04746.12 EDO17174.1 - 0.01 16.1 0.2 0.026 14.8 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF575) Roc PF08477.13 EDO17174.1 - 0.038 14.2 0.0 0.18 12.1 0.0 2.2 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_16 PF13191.6 EDO17174.1 - 0.061 13.7 0.1 0.29 11.5 0.0 2.1 2 1 0 2 2 2 0 AAA ATPase domain RNA_pol_N PF01194.17 EDO17175.1 - 2.1e-29 101.6 0.5 2.4e-29 101.4 0.5 1.0 1 0 0 1 1 1 1 RNA polymerases N / 8 kDa subunit WD40 PF00400.32 EDO17176.1 - 1.7e-05 25.5 5.3 0.0096 16.8 0.1 5.0 5 0 0 5 5 5 2 WD domain, G-beta repeat Ge1_WD40 PF16529.5 EDO17176.1 - 0.0022 17.0 0.2 1 8.2 0.0 3.0 3 0 0 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein NAPRTase PF04095.16 EDO17177.1 - 6.4e-77 258.4 0.1 8.6e-77 258.0 0.1 1.2 1 0 0 1 1 1 1 Nicotinate phosphoribosyltransferase (NAPRTase) family NAPRTase_N PF17767.1 EDO17177.1 - 1.8e-33 115.6 0.9 3.6e-33 114.6 0.9 1.5 1 0 0 1 1 1 1 Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain Y_phosphatase PF00102.27 EDO17178.1 - 5.4e-63 212.7 2.0 1.4e-62 211.3 2.0 1.8 1 1 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 EDO17178.1 - 0.00087 19.1 0.1 0.0064 16.3 0.0 2.6 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 EDO17178.1 - 0.0035 17.4 0.5 0.038 14.0 0.2 2.4 1 1 1 2 2 2 1 Tyrosine phosphatase family Noc2 PF03715.13 EDO17179.1 - 1.3e-121 405.5 9.3 1.3e-121 405.5 9.3 2.4 2 0 0 2 2 2 1 Noc2p family Nop14 PF04147.12 EDO17179.1 - 0.013 13.8 0.2 0.013 13.8 0.2 3.4 2 1 1 3 3 3 0 Nop14-like family DEAD PF00270.29 EDO17180.1 - 9.3e-48 162.3 0.0 3.4e-47 160.5 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDO17180.1 - 7.6e-32 110.0 0.0 1.4e-31 109.1 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDO17180.1 - 0.001 19.1 0.0 0.002 18.2 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 EDO17180.1 - 0.027 13.7 0.0 0.042 13.0 0.0 1.2 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase CMS1 PF14617.6 EDO17180.1 - 0.11 11.8 0.1 0.32 10.3 0.0 1.6 2 0 0 2 2 2 0 U3-containing 90S pre-ribosomal complex subunit Mit_ribos_Mrp51 PF11709.8 EDO17181.1 - 1.1e-55 189.8 7.1 7.3e-54 183.7 7.1 2.8 1 1 0 1 1 1 1 Mitochondrial ribosomal protein subunit SpoU_methylase PF00588.19 EDO17182.1 - 1.2e-23 83.9 0.1 3.9e-22 78.9 0.0 2.7 2 1 0 2 2 2 1 SpoU rRNA Methylase family SpoU_sub_bind PF08032.12 EDO17182.1 - 3.2e-14 52.9 0.0 5.8e-14 52.1 0.0 1.4 1 0 0 1 1 1 1 RNA 2'-O ribose methyltransferase substrate binding FapA PF03961.13 EDO17183.1 - 0.0051 15.5 16.3 0.0051 15.5 16.3 3.8 2 1 1 3 3 3 1 Flagellar Assembly Protein A Baculo_PEP_C PF04513.12 EDO17183.1 - 0.043 13.8 29.7 1.3 9.0 2.5 5.4 2 1 2 5 5 5 0 Baculovirus polyhedron envelope protein, PEP, C terminus WD40_alt PF14077.6 EDO17183.1 - 0.07 13.0 9.3 17 5.3 0.4 4.8 5 0 0 5 5 5 0 Alternative WD40 repeat motif MtrG PF04210.13 EDO17183.1 - 2.1 8.2 7.9 24 4.9 0.2 4.5 4 0 0 4 4 4 0 Tetrahydromethanopterin S-methyltransferase, subunit G Peptidase_C14 PF00656.22 EDO17184.1 - 6.6e-63 212.9 0.3 8.5e-63 212.6 0.3 1.1 1 0 0 1 1 1 1 Caspase domain FAM176 PF14851.6 EDO17184.1 - 0.15 11.7 0.0 0.25 11.0 0.0 1.3 1 0 0 1 1 1 0 FAM176 family FHA PF00498.26 EDO17185.1 - 7.9e-13 48.6 1.4 9.6e-13 48.3 0.3 1.8 2 0 0 2 2 1 1 FHA domain zf-RING_2 PF13639.6 EDO17185.1 - 3.6e-07 30.4 8.8 6.3e-07 29.6 8.8 1.4 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 EDO17185.1 - 1.6e-06 27.7 9.9 3.2e-06 26.8 9.9 1.5 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_3 PF13920.6 EDO17185.1 - 0.003 17.4 3.7 0.005 16.7 3.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EDO17185.1 - 0.0035 17.2 9.4 0.0063 16.4 9.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 EDO17185.1 - 0.0058 16.7 5.1 0.018 15.1 5.1 1.8 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.7 EDO17185.1 - 0.012 15.9 6.7 0.027 14.8 6.7 1.6 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_5 PF14634.6 EDO17185.1 - 0.016 15.2 7.3 0.027 14.4 7.3 1.4 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4_2 PF13923.6 EDO17185.1 - 0.026 14.4 8.4 0.049 13.5 8.4 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Yop-YscD_cpl PF16697.5 EDO17185.1 - 0.097 13.0 0.0 0.18 12.2 0.0 1.4 1 0 0 1 1 1 0 Inner membrane component of T3SS, cytoplasmic domain zf-RING_UBOX PF13445.6 EDO17185.1 - 2.1 8.4 7.8 4.4 7.4 7.8 1.6 1 0 0 1 1 1 0 RING-type zinc-finger SH3_9 PF14604.6 EDO17186.1 - 5.5e-24 83.8 0.1 5.3e-13 48.6 0.0 2.5 2 0 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.28 EDO17186.1 - 1.3e-22 79.2 0.2 1.4e-12 47.0 0.1 2.8 2 0 0 2 2 2 2 SH3 domain FCH PF00611.23 EDO17186.1 - 5.5e-17 61.8 0.1 5.5e-17 61.8 0.1 2.3 3 0 0 3 3 3 1 Fes/CIP4, and EFC/F-BAR homology domain SH3_2 PF07653.17 EDO17186.1 - 1.2e-14 53.7 0.0 2.2e-09 36.9 0.0 2.6 2 0 0 2 2 2 2 Variant SH3 domain SH3_10 PF17902.1 EDO17186.1 - 0.001 19.1 0.0 0.028 14.5 0.0 2.8 2 0 0 2 2 2 1 SH3 domain TRAPP PF04051.16 EDO17187.1 - 2.8e-31 108.2 0.0 3.7e-31 107.8 0.0 1.1 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component zf-H2C2_2 PF13465.6 EDO17188.1 - 6.1e-21 73.8 24.6 2.6e-08 33.9 0.9 4.8 5 0 0 5 5 4 4 Zinc-finger double domain zf-C2H2 PF00096.26 EDO17188.1 - 3.8e-20 71.2 30.5 2.1e-05 24.7 0.9 4.9 5 0 0 5 5 4 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EDO17188.1 - 3e-10 40.0 32.1 0.0022 18.7 0.6 5.3 6 0 0 6 6 5 4 C2H2-type zinc finger zf-Di19 PF05605.12 EDO17188.1 - 0.0011 19.2 6.9 0.021 15.1 0.3 2.6 2 0 0 2 2 2 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_jaz PF12171.8 EDO17188.1 - 0.0014 18.9 14.6 0.35 11.2 0.2 4.7 4 0 0 4 4 4 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EDO17188.1 - 0.0037 17.6 20.8 0.015 15.6 0.3 5.4 5 0 0 5 5 5 1 Zinc-finger of C2H2 type HNH PF01844.23 EDO17188.1 - 0.26 11.5 10.9 25 5.2 0.6 4.4 4 0 0 4 4 4 0 HNH endonuclease DZR PF12773.7 EDO17188.1 - 0.66 10.1 3.8 4 7.5 3.3 2.3 1 1 1 2 2 2 0 Double zinc ribbon PyrI_C PF02748.15 EDO17188.1 - 0.71 9.8 6.1 5.8 6.9 0.2 3.4 3 0 0 3 3 3 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2H2_6 PF13912.6 EDO17188.1 - 0.71 9.9 25.8 0.042 13.9 1.1 4.9 4 0 0 4 4 4 0 C2H2-type zinc finger DUF2256 PF10013.9 EDO17188.1 - 0.91 9.7 3.2 20 5.4 0.0 3.2 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2256) zf-LYAR PF08790.11 EDO17188.1 - 1.2 9.1 4.6 47 4.0 0.1 3.5 3 0 0 3 3 3 0 LYAR-type C2HC zinc finger Zn-ribbon_8 PF09723.10 EDO17188.1 - 2.4 8.3 9.6 0.64 10.2 1.9 3.3 3 1 0 3 3 3 0 Zinc ribbon domain zf-C2H2_11 PF16622.5 EDO17188.1 - 7.9 6.3 12.2 2.7 7.8 0.6 3.2 3 0 0 3 3 3 0 zinc-finger C2H2-type zf-CHCC PF10276.9 EDO17188.1 - 8.9 6.5 13.3 10 6.3 2.5 3.2 3 0 0 3 3 3 0 Zinc-finger domain gag_pre-integrs PF13976.6 EDO17189.1 - 0.0017 18.2 0.4 0.0032 17.3 0.4 1.5 1 0 0 1 1 1 1 GAG-pre-integrase domain Retrotran_gag_2 PF14223.6 EDO17190.1 - 0.019 14.6 0.1 0.035 13.8 0.1 1.4 1 0 0 1 1 1 0 gag-polypeptide of LTR copia-type WhiA_N PF10298.9 EDO17190.1 - 0.053 13.6 0.0 2.4 8.3 0.0 2.5 2 0 0 2 2 2 0 WhiA N-terminal LAGLIDADG-like domain RVT_1 PF00078.27 EDO17191.1 - 2.5e-15 56.6 0.1 4.8e-14 52.4 0.1 2.5 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 EDO17191.1 - 1.7e-14 53.7 0.0 5.5e-14 52.0 0.0 1.9 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 EDO17191.1 - 2.7e-14 53.3 0.0 8.3e-14 51.8 0.0 1.9 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 EDO17191.1 - 1e-13 51.5 0.0 2.1e-13 50.5 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain MLVIN_C PF18697.1 EDO17191.1 - 0.024 14.7 0.4 0.074 13.1 0.4 1.8 1 0 0 1 1 1 0 Murine leukemia virus (MLV) integrase (IN) C-terminal domain Minor_capsid_2 PF11114.8 EDO17191.1 - 0.13 12.3 0.9 0.38 10.8 0.1 2.0 2 0 0 2 2 2 0 Minor capsid protein Baculo_PEP_C PF04513.12 EDO17192.1 - 0.03 14.4 4.0 0.39 10.8 4.1 2.3 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Vps51 PF08700.11 EDO17192.1 - 0.095 12.8 3.1 0.17 12.0 0.5 2.6 2 0 0 2 2 2 0 Vps51/Vps67 CpxA_peri PF16527.5 EDO17192.1 - 0.35 11.2 2.0 9 6.7 0.4 2.4 1 1 1 2 2 2 0 Two-component sensor protein CpxA, periplasmic domain APG6_N PF17675.1 EDO17192.1 - 0.77 10.3 7.1 1.6 9.3 7.1 1.5 1 0 0 1 1 1 0 Apg6 coiled-coil region Pox_A3L PF05288.11 EDO17192.1 - 4.6 7.3 7.2 20 5.2 0.3 3.0 3 0 0 3 3 3 0 Poxvirus A3L Protein NPV_P10 PF05531.12 EDO17192.1 - 4.6 7.8 5.9 77 3.8 3.1 3.6 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein DcpS_C PF11969.8 EDO17194.1 - 1.5e-34 118.8 0.8 3.8e-34 117.6 0.8 1.6 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding DcpS PF05652.12 EDO17194.1 - 4e-27 95.1 0.1 7.1e-27 94.3 0.1 1.4 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme (DcpS) N-terminal HIT PF01230.23 EDO17194.1 - 0.0011 19.7 0.7 0.0033 18.1 0.1 2.2 3 0 0 3 3 3 1 HIT domain MBOAT PF03062.19 EDO17195.1 - 2.5e-52 178.4 19.5 2.5e-52 178.4 19.5 1.9 1 1 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family Ferrochelatase PF00762.19 EDO17196.1 - 1.6e-95 319.8 0.0 1.9e-95 319.6 0.0 1.0 1 0 0 1 1 1 1 Ferrochelatase Abhydrolase_1 PF00561.20 EDO17197.1 - 4.5e-20 72.4 0.1 5.9e-20 72.0 0.1 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EDO17197.1 - 9e-12 46.1 0.0 1.8e-11 45.1 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EDO17197.1 - 7.7e-08 31.9 0.0 1.7e-07 30.8 0.0 1.6 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Ser_hydrolase PF06821.13 EDO17197.1 - 0.0006 19.7 0.0 0.0012 18.7 0.0 1.4 1 0 0 1 1 1 1 Serine hydrolase Abhydrolase_2 PF02230.16 EDO17197.1 - 0.016 15.1 0.0 0.054 13.3 0.0 1.8 2 1 0 2 2 2 0 Phospholipase/Carboxylesterase Peptidase_S9 PF00326.21 EDO17197.1 - 0.016 14.7 0.0 0.19 11.1 0.0 2.2 2 0 0 2 2 2 0 Prolyl oligopeptidase family BPL_LplA_LipB PF03099.19 EDO17198.1 - 3.3e-05 23.8 0.2 0.00098 19.0 0.2 2.6 2 1 0 2 2 2 1 Biotin/lipoate A/B protein ligase family UPF0086 PF01868.16 EDO17199.1 - 1.7e-23 82.3 0.0 3.3e-23 81.4 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function UPF0086 RhoGAP PF00620.27 EDO17201.1 - 2.9e-34 118.1 1.1 8.1e-34 116.7 0.1 2.4 2 0 0 2 2 2 1 RhoGAP domain FCH PF00611.23 EDO17201.1 - 2.1e-06 27.9 4.1 3.3e-06 27.3 1.9 2.5 2 1 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain Med15_fungi PF05397.12 EDO17201.1 - 2.6 8.4 5.9 1.1 9.5 0.3 3.2 3 0 0 3 3 3 0 Mediator complex subunit 15 Methyltransf_PK PF05891.12 EDO17202.1 - 2.4e-93 311.7 0.0 2.7e-93 311.5 0.0 1.0 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Methyltransf_25 PF13649.6 EDO17202.1 - 8.3e-07 29.6 0.0 1.4e-06 28.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EDO17202.1 - 1.3e-05 25.1 0.0 2.4e-05 24.2 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EDO17202.1 - 0.0016 19.1 0.0 0.0031 18.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Bin3 PF06859.12 EDO17202.1 - 0.025 15.2 0.0 0.044 14.4 0.0 1.4 1 0 0 1 1 1 0 Bicoid-interacting protein 3 (Bin3) Methyltransf_2 PF00891.18 EDO17202.1 - 0.051 12.9 0.0 0.085 12.1 0.0 1.3 1 0 0 1 1 1 0 O-methyltransferase domain Rif1_N PF12231.8 EDO17203.1 - 5.7e-43 147.3 17.8 5.7e-43 147.3 17.8 2.1 2 0 0 2 2 2 1 Rap1-interacting factor 1 N terminal Pkinase PF00069.25 EDO17204.1 - 6.4e-56 189.6 0.0 8.3e-56 189.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO17204.1 - 1.5e-29 103.1 0.0 2e-29 102.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDO17204.1 - 1.3e-07 31.3 0.0 2.5e-07 30.3 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EDO17204.1 - 1.7e-05 23.8 0.0 2.8e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 EDO17204.1 - 0.0067 15.4 0.0 0.013 14.5 0.0 1.4 1 0 0 1 1 1 1 Haspin like kinase domain Seadorna_VP7 PF07387.11 EDO17204.1 - 0.0069 15.5 0.0 0.079 12.0 0.0 2.1 2 0 0 2 2 2 1 Seadornavirus VP7 Kdo PF06293.14 EDO17204.1 - 0.024 14.0 0.0 0.11 11.8 0.0 1.9 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family UBX PF00789.20 EDO17205.1 - 3e-18 65.8 0.0 1.3e-17 63.8 0.0 2.1 2 0 0 2 2 2 1 UBX domain HSM3_N PF18795.1 EDO17206.1 - 2.1e-75 253.2 17.3 3.5e-75 252.5 17.3 1.3 1 0 0 1 1 1 1 DNA mismatch repair protein HSM3, N terminal domain HSM3_C PF18794.1 EDO17206.1 - 9.6e-67 224.0 1.6 1.8e-66 223.1 1.6 1.5 1 0 0 1 1 1 1 DNA mismatch repair protein HSM3, C terminal domain rRNA_proc-arch PF13234.6 EDO17207.1 - 1e-83 281.4 2.3 2.2e-83 280.3 2.3 1.6 1 0 0 1 1 1 1 rRNA-processing arch domain DSHCT PF08148.12 EDO17207.1 - 1.1e-53 181.3 0.6 2.3e-53 180.2 0.6 1.6 1 0 0 1 1 1 1 DSHCT (NUC185) domain DEAD PF00270.29 EDO17207.1 - 4.6e-19 68.8 0.0 1.8e-17 63.7 0.0 2.9 2 1 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDO17207.1 - 3.3e-06 27.4 0.0 3.2e-05 24.2 0.0 2.5 1 1 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDO17207.1 - 0.0016 18.4 0.0 0.0056 16.7 0.0 1.9 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit DUF5335 PF17269.2 EDO17207.1 - 0.027 14.3 0.1 0.088 12.7 0.1 1.9 1 0 0 1 1 1 0 Family of unknown function (DUF5335) AAA_22 PF13401.6 EDO17207.1 - 0.042 14.1 0.0 0.14 12.4 0.0 2.0 1 0 0 1 1 1 0 AAA domain T2SSE PF00437.20 EDO17207.1 - 0.093 11.8 0.0 0.26 10.3 0.0 1.7 2 0 0 2 2 2 0 Type II/IV secretion system protein DUF4315 PF14193.6 EDO17207.1 - 0.16 12.0 3.0 1.5 8.9 1.8 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4315) zf-C2H2 PF00096.26 EDO17209.1 - 2.6e-24 84.3 48.4 1.4e-05 25.2 2.2 9.3 8 0 0 8 8 8 7 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EDO17209.1 - 1.5e-19 69.4 45.5 1.4e-07 31.6 0.5 7.2 8 0 0 8 8 6 4 Zinc-finger double domain Zap1_zf2 PF18217.1 EDO17209.1 - 8.3e-14 51.3 7.6 8.3e-14 51.3 7.6 4.6 4 0 0 4 4 3 1 Zap1 zinc finger 2 zf-met PF12874.7 EDO17209.1 - 6.3e-11 42.3 21.8 0.00059 20.1 1.2 5.4 4 0 0 4 4 4 3 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EDO17209.1 - 1.6e-07 31.4 29.5 8.1e-05 22.8 1.2 5.9 6 1 1 7 7 7 3 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 EDO17209.1 - 2.1e-07 31.2 15.6 0.00081 20.0 0.9 10.4 12 0 0 12 12 8 5 C2H2-type zinc finger zf-C2H2_6 PF13912.6 EDO17209.1 - 1.6e-06 27.9 11.5 2.3e-05 24.3 1.1 6.2 5 1 1 6 6 5 2 C2H2-type zinc finger zf_Hakai PF18408.1 EDO17209.1 - 0.00013 21.6 0.2 0.024 14.3 0.0 3.9 3 0 0 3 3 3 1 C2H2 Hakai zinc finger domain zf-C2H2_8 PF15909.5 EDO17209.1 - 0.00026 21.2 29.4 0.0005 20.3 3.3 4.9 3 2 3 6 6 6 3 C2H2-type zinc ribbon zf-C2H2_11 PF16622.5 EDO17209.1 - 0.00028 20.6 18.1 0.074 12.8 0.5 5.5 5 0 0 5 5 5 2 zinc-finger C2H2-type FOXP-CC PF16159.5 EDO17209.1 - 0.0052 17.4 42.5 0.017 15.7 1.5 8.4 6 3 3 9 9 9 3 FOXP coiled-coil domain Zn-ribbon_8 PF09723.10 EDO17209.1 - 0.035 14.2 19.3 0.49 10.6 0.1 5.2 4 1 1 5 5 5 0 Zinc ribbon domain zf-C2HC_2 PF13913.6 EDO17209.1 - 0.1 12.5 14.6 5.7 7.0 0.2 4.8 4 0 0 4 4 4 0 zinc-finger of a C2HC-type zf-MYST PF17772.1 EDO17209.1 - 0.52 10.0 10.3 1.3 8.7 3.8 3.6 3 1 0 3 3 3 0 MYST family zinc finger domain LIM PF00412.22 EDO17209.1 - 2.7 8.3 18.4 1.1 9.6 2.5 4.6 3 0 0 3 3 3 0 LIM domain Aminotran_1_2 PF00155.21 EDO17210.1 - 9.9e-83 278.3 0.0 1.2e-82 278.1 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 EDO17210.1 - 0.00093 18.6 0.0 0.0018 17.7 0.0 1.4 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_5 PF00266.19 EDO17210.1 - 0.00097 18.2 0.1 0.0033 16.4 0.1 1.8 1 1 0 1 1 1 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 EDO17210.1 - 0.0033 16.0 0.2 0.0076 14.8 0.2 1.6 1 1 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_3 PF00202.21 EDO17210.1 - 0.016 13.9 0.0 0.032 12.9 0.0 1.5 1 0 0 1 1 1 0 Aminotransferase class-III Sod_Fe_C PF02777.18 EDO17210.1 - 0.052 13.7 0.2 3.3 7.9 0.0 2.4 1 1 1 2 2 2 0 Iron/manganese superoxide dismutases, C-terminal domain DUF2240 PF09999.9 EDO17210.1 - 0.14 11.8 0.0 0.36 10.4 0.0 1.7 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2240) DUF5044 PF16447.5 EDO17211.1 - 0.031 14.1 0.0 0.062 13.1 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5044) DUF2431 PF10354.9 EDO17211.1 - 0.088 13.1 0.6 0.33 11.2 0.0 2.3 3 0 0 3 3 3 0 Domain of unknown function (DUF2431) FliT PF05400.13 EDO17211.1 - 1.3 9.9 6.9 0.22 12.4 1.3 2.5 1 1 2 3 3 3 0 Flagellar protein FliT Glutaredoxin2_C PF04399.13 EDO17211.1 - 5.4 6.9 7.3 26 4.7 0.2 3.3 1 1 2 3 3 3 0 Glutaredoxin 2, C terminal domain Ribosomal_L37 PF08561.10 EDO17212.1 - 9.7e-23 81.0 8.9 3.5e-18 66.3 0.2 2.1 1 1 1 2 2 2 2 Mitochondrial ribosomal protein L37 Phosphodiest PF01663.22 EDO17213.1 - 2.2e-13 50.6 0.5 9.6e-10 38.6 0.0 2.1 2 0 0 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase Metalloenzyme PF01676.18 EDO17213.1 - 7.2e-06 25.6 0.0 1.3e-05 24.7 0.0 1.3 1 0 0 1 1 1 1 Metalloenzyme superfamily Sulfatase PF00884.23 EDO17213.1 - 0.0002 20.9 0.1 0.00051 19.5 0.1 1.8 1 1 0 1 1 1 1 Sulfatase COQ9 PF08511.11 EDO17213.1 - 0.029 14.1 0.7 0.47 10.3 0.0 2.8 3 0 0 3 3 3 0 COQ9 zf-C2H2_2 PF12756.7 EDO17214.1 - 5.2e-34 116.6 7.4 2.1e-31 108.3 5.5 2.7 2 0 0 2 2 2 2 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.8 EDO17214.1 - 0.00053 20.2 3.5 0.14 12.5 0.2 3.1 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EDO17214.1 - 0.0073 16.7 0.7 0.0073 16.7 0.7 2.8 3 0 0 3 3 3 1 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 EDO17214.1 - 0.023 14.7 0.1 0.023 14.7 0.1 2.9 3 0 0 3 3 3 0 C2H2-type zinc finger DUF1460 PF07313.12 EDO17214.1 - 0.046 13.1 0.5 0.089 12.2 0.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1460) zf_UBZ PF18439.1 EDO17214.1 - 0.084 12.5 0.1 0.2 11.3 0.1 1.6 1 0 0 1 1 1 0 Ubiquitin-Binding Zinc Finger zf-C2H2_4 PF13894.6 EDO17214.1 - 0.16 12.8 8.9 1.1 10.2 0.0 3.9 3 1 1 4 4 4 0 C2H2-type zinc finger DUF3761 PF12587.8 EDO17214.1 - 0.23 11.9 0.8 0.84 10.1 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3761) zf-C2H2 PF00096.26 EDO17214.1 - 0.41 11.2 11.4 0.46 11.0 0.1 3.4 3 0 0 3 3 3 0 Zinc finger, C2H2 type adh_short PF00106.25 EDO17215.1 - 3e-20 72.5 0.0 6.8e-11 42.0 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase KR PF08659.10 EDO17215.1 - 5.2e-12 46.0 0.0 7.4e-12 45.5 0.0 1.2 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.6 EDO17215.1 - 5.1e-07 29.5 0.0 1.8e-05 24.4 0.0 2.0 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase Polysacc_synt_2 PF02719.15 EDO17215.1 - 0.021 14.0 0.0 0.031 13.4 0.0 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein A_deaminase PF00962.22 EDO17216.1 - 5.2e-88 295.5 0.0 5.9e-88 295.3 0.0 1.0 1 0 0 1 1 1 1 Adenosine/AMP deaminase TPR_1 PF00515.28 EDO17216.1 - 0.02 14.7 0.1 0.044 13.6 0.1 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat Aminotran_1_2 PF00155.21 EDO17217.1 - 2.7e-15 56.4 0.0 4.5e-15 55.7 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 EDO17217.1 - 0.0031 16.9 0.1 0.0045 16.3 0.1 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase ABC_tran PF00005.27 EDO17219.1 - 1.6e-17 64.3 0.0 3.7e-17 63.1 0.0 1.6 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 EDO17219.1 - 5.9e-08 32.9 0.2 0.0075 16.1 0.0 2.4 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EDO17219.1 - 2.1e-05 24.1 0.0 0.035 13.5 0.0 2.2 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EDO17219.1 - 0.0049 16.6 0.0 0.011 15.4 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain DUF3584 PF12128.8 EDO17219.1 - 0.012 13.2 0.1 0.015 12.8 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) AAA_18 PF13238.6 EDO17219.1 - 0.018 15.6 0.2 0.17 12.4 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 EDO17219.1 - 0.041 14.2 0.4 0.1 12.9 0.1 1.7 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.6 EDO17219.1 - 0.056 13.9 0.0 0.12 12.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 EDO17219.1 - 0.067 13.3 0.0 0.14 12.2 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase Dynamin_N PF00350.23 EDO17219.1 - 0.075 13.1 0.0 0.24 11.4 0.0 1.8 2 0 0 2 2 2 0 Dynamin family RsgA_GTPase PF03193.16 EDO17219.1 - 0.091 12.7 0.0 0.17 11.8 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase MutS_V PF00488.21 EDO17219.1 - 0.15 12.0 0.0 8 6.4 0.0 2.3 2 0 0 2 2 2 0 MutS domain V AAA_28 PF13521.6 EDO17219.1 - 0.22 11.7 0.1 0.38 11.0 0.1 1.4 1 0 0 1 1 1 0 AAA domain FA_hydroxylase PF04116.13 EDO17220.1 - 5.5e-21 75.3 18.3 5.5e-21 75.3 18.3 2.2 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily Pkinase PF00069.25 EDO17221.1 - 3.1e-32 112.0 3.3 8.3e-32 110.6 3.3 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO17221.1 - 1.5e-17 63.8 0.1 2.2e-17 63.2 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EDO17221.1 - 0.0048 15.7 0.3 0.0075 15.1 0.3 1.3 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EDO17221.1 - 0.0053 16.7 0.1 0.016 15.2 0.1 1.7 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 EDO17221.1 - 0.099 12.0 0.3 0.18 11.1 0.3 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Glyco_hydro_47 PF01532.20 EDO17222.1 - 4.2e-71 240.2 0.8 7.7e-71 239.3 0.8 1.4 1 1 0 1 1 1 1 Glycosyl hydrolase family 47 Glyco_hydro_76 PF03663.14 EDO17222.1 - 0.0011 18.6 0.0 1.5 8.3 0.0 2.5 2 0 0 2 2 2 2 Glycosyl hydrolase family 76 SHMT PF00464.19 EDO17223.1 - 2.6e-204 678.3 0.0 3e-204 678.1 0.0 1.0 1 0 0 1 1 1 1 Serine hydroxymethyltransferase Beta_elim_lyase PF01212.21 EDO17223.1 - 6e-05 22.5 0.0 0.0001 21.7 0.0 1.4 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_1_2 PF00155.21 EDO17223.1 - 0.00037 19.8 0.0 0.0016 17.7 0.0 1.9 1 1 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 EDO17223.1 - 0.042 12.8 0.0 0.059 12.3 0.0 1.1 1 0 0 1 1 1 0 Aminotransferase class-V DUF4456 PF14644.6 EDO17223.1 - 0.13 11.9 0.5 0.25 11.0 0.1 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4456) Aminotran_5 PF00266.19 EDO17224.1 - 1.9e-24 86.3 0.0 2.7e-24 85.8 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-V B12-binding PF02310.19 EDO17224.1 - 0.0043 17.1 0.0 0.012 15.6 0.0 1.7 1 0 0 1 1 1 1 B12 binding domain Met_gamma_lyase PF06838.11 EDO17224.1 - 0.013 14.0 0.2 0.024 13.2 0.2 1.5 1 1 0 1 1 1 0 Methionine gamma-lyase bZIP_2 PF07716.15 EDO17225.1 - 0.00028 20.9 7.2 0.00028 20.9 7.2 1.7 1 1 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.21 EDO17225.1 - 0.00034 20.6 7.8 0.00034 20.6 7.8 2.0 2 0 0 2 2 2 1 bZIP transcription factor RNase_T PF00929.24 EDO17226.1 - 3.8e-32 112.1 0.1 5.7e-32 111.5 0.1 1.3 1 0 0 1 1 1 1 Exonuclease HEPN_AbiA_CTD PF18732.1 EDO17226.1 - 0.019 14.9 0.1 0.086 12.8 0.1 2.1 2 0 0 2 2 2 0 HEPN like, Abia C-terminal domain DUF1741 PF08427.10 EDO17226.1 - 0.021 14.5 2.9 0.028 14.1 1.3 1.8 1 1 0 2 2 2 0 Domain of unknown function (DUF1741) PAS_9 PF13426.7 EDO17227.1 - 0.076 13.3 0.2 1.6 9.0 0.0 2.3 2 0 0 2 2 2 0 PAS domain Pkinase PF00069.25 EDO17228.1 - 3.3e-61 206.9 0.1 1.1e-37 129.9 0.2 2.4 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EDO17228.1 - 1.3e-26 93.4 0.5 3.5e-20 72.4 0.1 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Response_reg PF00072.24 EDO17228.1 - 2.5e-05 24.4 0.0 5.8e-05 23.2 0.0 1.7 1 0 0 1 1 1 1 Response regulator receiver domain Kinase-like PF14531.6 EDO17228.1 - 5.5e-05 22.6 0.8 0.0076 15.6 0.0 2.9 3 0 0 3 3 3 1 Kinase-like APH PF01636.23 EDO17228.1 - 0.0018 18.3 0.0 0.34 10.8 0.3 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 EDO17228.1 - 0.0046 16.3 0.0 0.0086 15.4 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 EDO17228.1 - 0.014 15.0 0.2 0.041 13.5 0.2 1.7 1 1 0 1 1 1 0 RIO1 family Haspin_kinase PF12330.8 EDO17228.1 - 0.2 10.5 6.9 0.077 11.9 0.1 3.0 2 1 0 2 2 2 0 Haspin like kinase domain tRNA_synthFbeta PF17759.1 EDO17229.1 - 2e-41 141.8 0.0 3.9e-41 140.9 0.0 1.5 2 0 0 2 2 2 1 Phenylalanyl tRNA synthetase beta chain CLM domain PhetRS_B1 PF18262.1 EDO17229.1 - 2.3e-31 107.8 0.8 1.9e-29 101.7 0.4 2.5 2 0 0 2 2 2 1 Phe-tRNA synthetase beta subunit B1 domain B3_4 PF03483.17 EDO17229.1 - 5.2e-27 94.6 0.0 1.1e-26 93.6 0.0 1.6 1 0 0 1 1 1 1 B3/4 domain B5 PF03484.15 EDO17229.1 - 1.2e-18 67.2 0.0 1.2e-16 60.7 0.0 2.7 2 0 0 2 2 2 1 tRNA synthetase B5 domain Herpes_V23 PF01802.17 EDO17229.1 - 0.013 15.0 0.0 0.021 14.3 0.0 1.3 1 0 0 1 1 1 0 Herpesvirus VP23 like capsid protein DUF1512 PF07431.12 EDO17229.1 - 0.06 12.3 0.2 0.099 11.6 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1512) DUF4868 PF16162.5 EDO17229.1 - 0.07 13.1 0.9 0.15 12.0 0.3 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4868) eIF-1a PF01176.19 EDO17229.1 - 0.1 12.4 0.0 0.26 11.1 0.0 1.6 1 0 0 1 1 1 0 Translation initiation factor 1A / IF-1 DUF726 PF05277.12 EDO17230.1 - 6.9e-140 465.8 1.1 1.1e-139 465.1 1.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF726) Ribosomal_L22e PF01776.17 EDO17231.1 - 2.7e-39 133.9 0.6 3.2e-39 133.7 0.6 1.0 1 0 0 1 1 1 1 Ribosomal L22e protein family Mob1_phocein PF03637.17 EDO17232.1 - 4.1e-65 218.9 1.5 4.1e-65 218.9 1.5 1.7 2 0 0 2 2 2 1 Mob1/phocein family Peptidase_S64 PF08192.11 EDO17232.1 - 0.019 13.5 5.1 0.03 12.8 5.1 1.2 1 0 0 1 1 1 0 Peptidase family S64 Nha1_C PF08619.10 EDO17232.1 - 0.051 12.8 8.8 0.067 12.4 8.8 1.0 1 0 0 1 1 1 0 Alkali metal cation/H+ antiporter Nha1 C terminus Spt20 PF12090.8 EDO17232.1 - 4 7.0 23.8 6.3 6.3 23.8 1.3 1 0 0 1 1 1 0 Spt20 family Presenilin PF01080.17 EDO17232.1 - 9.8 4.8 9.9 14 4.3 9.9 1.2 1 0 0 1 1 1 0 Presenilin IF2_N PF04760.15 EDO17233.1 - 0.14 12.0 1.3 15 5.5 0.1 3.4 3 0 0 3 3 3 0 Translation initiation factor IF-2, N-terminal region Tubulin PF00091.25 EDO17234.1 - 1.1e-67 228.1 0.0 1.9e-67 227.3 0.0 1.4 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EDO17234.1 - 1.1e-41 141.9 0.0 2e-41 141.1 0.0 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 EDO17234.1 - 0.0021 17.8 0.0 0.0037 17.0 0.0 1.4 1 0 0 1 1 1 1 Tubulin domain Tubulin_2 PF13809.6 EDO17234.1 - 0.0058 15.9 0.0 0.011 14.9 0.0 1.4 1 0 0 1 1 1 1 Tubulin like Misat_Tub_SegII PF10644.9 EDO17234.1 - 0.025 14.9 0.0 0.064 13.6 0.0 1.7 1 0 0 1 1 1 0 Misato Segment II tubulin-like domain Histone PF00125.24 EDO17235.1 - 1.1e-15 58.2 0.0 1.3e-15 57.9 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Histone_H2A_C PF16211.5 EDO17235.1 - 1.6e-13 50.1 1.0 3e-13 49.3 1.0 1.4 1 0 0 1 1 1 1 C-terminus of histone H2A CBFD_NFYB_HMF PF00808.23 EDO17235.1 - 0.0074 16.6 0.0 0.01 16.1 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone zf-RING_2 PF13639.6 EDO17236.1 - 4.5e-09 36.5 3.0 4.5e-09 36.5 3.0 2.2 2 0 0 2 2 2 1 Ring finger domain zf-rbx1 PF12678.7 EDO17236.1 - 1.3e-07 31.8 3.7 3.1e-07 30.6 3.7 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 EDO17236.1 - 3.3e-06 27.0 3.5 8.9e-06 25.6 3.5 1.7 1 1 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EDO17236.1 - 3.3e-05 23.8 2.7 0.00011 22.2 2.7 2.0 1 1 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 EDO17236.1 - 7.3e-05 22.6 1.6 7.3e-05 22.6 1.6 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EDO17236.1 - 7.9e-05 22.4 1.9 7.9e-05 22.4 1.9 1.6 2 0 0 2 2 1 1 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.25 EDO17236.1 - 0.00025 20.8 7.8 0.00095 19.0 7.8 2.0 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EDO17236.1 - 0.00034 20.4 4.1 0.00034 20.4 4.1 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 EDO17236.1 - 0.0012 18.4 0.3 0.0026 17.4 0.3 1.5 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-ANAPC11 PF12861.7 EDO17236.1 - 0.015 15.3 0.9 0.035 14.2 0.9 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_4 PF15227.6 EDO17236.1 - 0.029 14.5 1.8 0.029 14.5 1.8 2.0 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING Cid2 PF09774.9 EDO17236.1 - 0.052 14.0 3.4 0.14 12.6 3.4 1.7 1 0 0 1 1 1 0 Caffeine-induced death protein 2 AzlD PF05437.12 EDO17236.1 - 0.14 12.4 3.3 0.13 12.5 1.6 1.9 1 1 0 1 1 1 0 Branched-chain amino acid transport protein (AzlD) TFIIA PF03153.13 EDO17236.1 - 0.15 12.1 14.5 0.33 10.9 9.4 2.6 3 0 0 3 3 3 0 Transcription factor IIA, alpha/beta subunit zf-RING-like PF08746.11 EDO17236.1 - 0.2 12.0 1.6 0.38 11.1 1.6 1.4 1 0 0 1 1 1 0 RING-like domain zf-RING_4 PF14570.6 EDO17236.1 - 0.36 10.7 2.4 0.81 9.5 0.8 2.2 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain zf-P11 PF03854.14 EDO17236.1 - 0.64 9.7 6.5 0.11 12.1 2.4 1.9 2 0 0 2 2 1 0 P-11 zinc finger CTU2 PF10288.9 EDO17236.1 - 1.1 9.5 12.3 16 5.8 12.0 2.8 1 1 0 1 1 1 0 Cytoplasmic tRNA 2-thiolation protein 2 zf-RVT PF13966.6 EDO17236.1 - 2.4 8.9 6.6 0.55 11.0 0.3 2.9 3 0 0 3 3 3 0 zinc-binding in reverse transcriptase zf-RING_11 PF17123.5 EDO17236.1 - 5.7 6.8 9.6 0.1 12.3 0.6 2.5 3 0 0 3 3 2 0 RING-like zinc finger RINGv PF12906.7 EDO17236.1 - 9 6.5 8.0 0.46 10.6 2.3 1.8 2 0 0 2 2 1 0 RING-variant domain CDP-OH_P_transf PF01066.21 EDO17239.1 - 7e-11 42.7 0.3 7e-11 42.7 0.3 1.8 2 0 0 2 2 2 1 CDP-alcohol phosphatidyltransferase ACOX PF01756.19 EDO17240.1 - 3.6e-44 150.5 0.0 9e-44 149.2 0.0 1.7 1 0 0 1 1 1 1 Acyl-CoA oxidase Acyl-CoA_dh_M PF02770.19 EDO17240.1 - 6e-21 74.5 0.0 1.1e-20 73.6 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_ox_N PF14749.6 EDO17240.1 - 1.5e-12 48.1 0.0 4.1e-12 46.7 0.0 1.7 1 0 0 1 1 1 1 Acyl-coenzyme A oxidase N-terminal Acyl-CoA_dh_1 PF00441.24 EDO17240.1 - 0.00037 20.7 0.0 0.002 18.4 0.0 2.1 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain F_actin_bind PF08919.10 EDO17240.1 - 0.05 13.7 1.2 24 5.0 0.1 3.4 4 0 0 4 4 4 0 F-actin binding zf-CCHC PF00098.23 EDO17241.1 - 7.6e-12 44.7 40.7 4.3e-05 23.4 4.0 5.3 5 0 0 5 5 5 3 Zinc knuckle zf-CCHC_2 PF13696.6 EDO17241.1 - 0.00076 19.3 1.6 0.00076 19.3 1.6 5.3 5 0 0 5 5 5 3 Zinc knuckle zf-C2H2_10 PF16588.5 EDO17241.1 - 0.0036 17.0 2.5 0.0036 17.0 2.5 4.6 3 1 1 4 4 4 1 C2H2 zinc-finger zf-CCHC_4 PF14392.6 EDO17241.1 - 0.77 9.6 32.0 0.83 9.4 1.7 5.2 4 1 1 5 5 5 0 Zinc knuckle Sec7 PF01369.20 EDO17243.1 - 1.1e-30 106.6 1.7 2.2e-30 105.7 1.7 1.5 1 0 0 1 1 1 1 Sec7 domain PHF5 PF03660.14 EDO17244.1 - 6.9e-51 170.8 12.8 7.7e-51 170.7 12.8 1.0 1 0 0 1 1 1 1 PHF5-like protein RecR PF02132.15 EDO17244.1 - 0.11 12.1 0.8 0.11 12.1 0.8 3.3 3 1 0 3 3 3 0 RecR protein COPI_C PF06957.11 EDO17244.1 - 1.9 7.2 3.4 2.4 6.8 3.4 1.1 1 0 0 1 1 1 0 Coatomer (COPI) alpha subunit C-terminus PolC_DP2 PF03833.13 EDO17244.1 - 4.9 4.9 8.4 5.1 4.8 8.4 1.1 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 zf-RING_2 PF13639.6 EDO17245.1 - 6.2e-09 36.1 30.9 2e-08 34.4 11.6 2.3 2 0 0 2 2 2 2 Ring finger domain zf-RING_UBOX PF13445.6 EDO17245.1 - 1.6e-07 31.3 7.6 1.6e-07 31.3 7.6 2.1 2 1 0 2 2 1 1 RING-type zinc-finger zf-RING_11 PF17123.5 EDO17245.1 - 5.6e-07 29.2 10.9 5.6e-07 29.2 10.9 2.9 2 1 0 2 2 1 1 RING-like zinc finger zf-RING_5 PF14634.6 EDO17245.1 - 1.3e-05 25.1 10.2 1.3e-05 25.1 10.2 2.7 2 1 0 2 2 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 EDO17245.1 - 1.3e-05 25.0 11.0 1.3e-05 25.0 11.0 2.7 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EDO17245.1 - 1.3e-05 24.9 10.7 1.3e-05 24.9 10.7 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EDO17245.1 - 0.0016 18.7 12.3 0.0016 18.7 12.3 3.3 3 1 0 3 3 3 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 EDO17245.1 - 0.0072 16.4 13.6 0.0084 16.1 3.5 2.6 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-HC5HC2H_2 PF13832.6 EDO17245.1 - 0.025 14.7 16.0 0.027 14.6 3.3 2.6 2 0 0 2 2 2 0 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 EDO17245.1 - 0.082 13.2 22.5 0.19 12.0 6.9 3.1 2 2 1 3 3 3 0 PHD-like zinc-binding domain PHD PF00628.29 EDO17245.1 - 0.44 10.5 30.3 0.32 10.9 12.6 2.5 2 0 0 2 2 2 0 PHD-finger Zn_ribbon_17 PF17120.5 EDO17245.1 - 1.9 8.2 23.1 0.096 12.3 7.8 2.5 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type Zf_RING PF16744.5 EDO17245.1 - 6.7 6.9 20.2 0.15 12.2 4.0 2.8 3 0 0 3 3 3 0 KIAA1045 RING finger Cofilin_ADF PF00241.20 EDO17246.1 - 9e-25 86.8 2.9 2e-11 43.7 0.2 2.4 2 1 0 2 2 2 2 Cofilin/tropomyosin-type actin-binding protein Plasmid_parti PF01672.16 EDO17246.1 - 0.12 13.0 0.6 0.51 11.0 0.1 2.3 2 0 0 2 2 2 0 Putative plasmid partition protein PH PF00169.29 EDO17247.1 - 1.1e-06 29.0 0.1 7.3e-06 26.5 0.1 2.4 1 1 0 1 1 1 1 PH domain MMM1 PF10296.9 EDO17247.1 - 3.7e-06 26.2 0.4 3.7e-06 26.2 0.4 2.3 2 1 0 2 2 2 1 Maintenance of mitochondrial morphology protein 1 PH_11 PF15413.6 EDO17247.1 - 0.00021 21.6 0.0 0.00021 21.6 0.0 3.0 3 2 0 3 3 3 1 Pleckstrin homology domain CKS PF01111.19 EDO17248.1 - 2.8e-33 114.0 0.1 4.2e-33 113.4 0.1 1.3 1 0 0 1 1 1 1 Cyclin-dependent kinase regulatory subunit DIL PF01843.19 EDO17249.1 - 1e-13 51.4 9.2 6.6e-07 29.6 0.2 3.2 4 0 0 4 4 4 2 DIL domain Na_trans_assoc PF06512.13 EDO17249.1 - 0.0003 21.1 0.1 0.0016 18.7 0.1 2.2 1 1 0 1 1 1 1 Sodium ion transport-associated DIMCO_N PF16844.5 EDO17249.1 - 0.19 12.1 0.3 0.63 10.4 0.0 2.0 2 0 0 2 2 2 0 Dinitrogenase iron-molybdenum cofactor, N-terminal SRP54 PF00448.22 EDO17250.1 - 3.5e-79 265.0 4.7 1.3e-78 263.1 0.5 2.7 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain SRP_SPB PF02978.19 EDO17250.1 - 1.4e-28 99.5 10.1 1.4e-28 99.5 10.1 4.4 4 0 0 4 4 4 1 Signal peptide binding domain SRP54_N PF02881.19 EDO17250.1 - 4.4e-14 52.4 3.5 4.4e-14 52.4 3.5 2.1 2 0 0 2 2 2 1 SRP54-type protein, helical bundle domain cobW PF02492.19 EDO17250.1 - 8.5e-06 25.5 2.9 0.00019 21.1 1.1 3.5 3 1 0 3 3 3 1 CobW/HypB/UreG, nucleotide-binding domain AAA_33 PF13671.6 EDO17250.1 - 2.3e-05 24.6 0.0 9e-05 22.7 0.0 2.0 2 0 0 2 2 2 1 AAA domain SRPRB PF09439.10 EDO17250.1 - 2.8e-05 23.6 2.5 0.9 8.9 0.1 3.9 3 1 0 3 3 3 2 Signal recognition particle receptor beta subunit AAA_17 PF13207.6 EDO17250.1 - 4.4e-05 23.9 1.3 0.00018 21.9 0.1 2.6 2 0 0 2 2 2 1 AAA domain CbiA PF01656.23 EDO17250.1 - 0.00016 21.7 0.0 0.00049 20.2 0.0 2.2 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain MeaB PF03308.16 EDO17250.1 - 0.0015 17.6 0.1 0.015 14.3 0.0 2.8 1 1 1 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB MobB PF03205.14 EDO17250.1 - 0.0017 18.2 0.3 0.0057 16.6 0.0 2.0 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B Zeta_toxin PF06414.12 EDO17250.1 - 0.003 16.9 1.4 0.0054 16.0 0.1 2.1 3 0 0 3 3 3 1 Zeta toxin AAA_16 PF13191.6 EDO17250.1 - 0.0038 17.6 0.0 0.014 15.7 0.0 1.9 1 1 1 2 2 2 1 AAA ATPase domain AAA_30 PF13604.6 EDO17250.1 - 0.0069 16.1 0.0 0.021 14.5 0.0 1.9 1 0 0 1 1 1 1 AAA domain MipZ PF09140.11 EDO17250.1 - 0.01 15.2 0.1 0.43 9.8 0.1 2.6 1 1 0 1 1 1 0 ATPase MipZ ATP_bind_1 PF03029.17 EDO17250.1 - 0.012 15.4 0.3 0.051 13.3 0.1 2.2 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_18 PF13238.6 EDO17250.1 - 0.013 16.0 0.5 0.15 12.6 0.0 2.9 3 0 0 3 3 3 0 AAA domain AAA_22 PF13401.6 EDO17250.1 - 0.021 15.1 0.4 0.11 12.7 0.4 2.5 1 1 0 1 1 1 0 AAA domain APS_kinase PF01583.20 EDO17250.1 - 0.023 14.6 0.0 0.053 13.4 0.0 1.6 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA_24 PF13479.6 EDO17250.1 - 0.041 13.6 2.5 0.07 12.9 0.0 2.4 2 1 1 3 3 3 0 AAA domain AAA_31 PF13614.6 EDO17250.1 - 0.11 12.4 0.1 0.11 12.4 0.1 3.3 2 1 1 4 4 4 0 AAA domain MMR_HSR1 PF01926.23 EDO17250.1 - 0.16 12.1 2.0 0.7 10.0 0.1 3.0 3 1 0 3 3 3 0 50S ribosome-binding GTPase AAA_28 PF13521.6 EDO17250.1 - 0.16 12.2 0.1 0.54 10.5 0.0 1.9 2 0 0 2 2 2 0 AAA domain NTPase_1 PF03266.15 EDO17250.1 - 1.3 8.9 7.0 0.58 10.1 0.2 2.7 2 1 1 3 3 2 0 NTPase AAA PF00004.29 EDO17250.1 - 1.3 9.4 9.5 0.28 11.6 1.4 3.7 3 1 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) TFIIB PF00382.19 EDO17251.1 - 1.9e-42 143.2 2.6 3.7e-27 94.2 1.0 2.3 2 0 0 2 2 2 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.12 EDO17251.1 - 1.1e-12 47.3 0.9 2e-12 46.4 0.9 1.5 1 0 0 1 1 1 1 TFIIB zinc-binding zf-ribbon_3 PF13248.6 EDO17251.1 - 0.12 11.8 0.5 3.1 7.3 0.0 2.5 2 0 0 2 2 2 0 zinc-ribbon domain RecO_N PF11967.8 EDO17251.1 - 0.16 12.0 0.1 0.34 10.9 0.1 1.5 1 0 0 1 1 1 0 Recombination protein O N terminal PH PF00169.29 EDO17252.1 - 8.4e-07 29.5 12.2 7e-06 26.5 0.1 3.5 2 1 0 2 2 2 2 PH domain PH_11 PF15413.6 EDO17252.1 - 7.1 7.1 13.7 6.1 7.3 3.1 3.7 2 2 1 3 3 3 0 Pleckstrin homology domain WD40 PF00400.32 EDO17253.1 - 0.58 11.1 3.2 8 7.5 0.1 3.9 4 0 0 4 4 4 0 WD domain, G-beta repeat MMR_HSR1 PF01926.23 EDO17254.1 - 0.0019 18.2 0.3 0.07 13.2 0.3 2.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_28 PF13521.6 EDO17254.1 - 0.01 16.1 1.5 0.014 15.7 0.0 1.9 2 0 0 2 2 2 0 AAA domain Arf PF00025.21 EDO17254.1 - 0.011 15.2 0.2 0.026 14.0 0.0 1.7 2 0 0 2 2 2 0 ADP-ribosylation factor family Ras PF00071.22 EDO17254.1 - 0.037 13.6 0.0 0.63 9.6 0.0 2.3 2 0 0 2 2 2 0 Ras family Dynamin_N PF00350.23 EDO17254.1 - 2 8.5 5.3 7.9 6.5 2.7 2.7 2 1 0 2 2 2 0 Dynamin family ATP-synt_ab PF00006.25 EDO17255.1 - 2.1e-66 223.6 0.0 3e-66 223.1 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 EDO17255.1 - 5.4e-16 58.9 1.1 1.1e-15 57.9 1.1 1.5 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain HAS-barrel PF09378.10 EDO17255.1 - 0.061 13.5 0.6 0.18 12.0 0.4 1.9 2 0 0 2 2 2 0 HAS barrel domain HGTP_anticodon PF03129.20 EDO17256.1 - 5.8e-19 68.0 0.1 1.6e-18 66.7 0.1 1.8 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_2b PF00587.25 EDO17256.1 - 1.2e-07 31.9 0.1 3.4e-07 30.4 0.1 1.9 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Ribosomal_L20 PF00453.18 EDO17257.1 - 0.093 12.8 0.2 0.26 11.4 0.1 1.9 1 1 1 2 2 2 0 Ribosomal protein L20 SOR PF07682.11 EDO17257.1 - 0.11 11.4 0.1 0.11 11.3 0.1 1.1 1 0 0 1 1 1 0 Sulphur oxygenase reductase GTP_EFTU PF00009.27 EDO17258.1 - 1e-54 185.1 0.0 1.5e-54 184.5 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 EDO17258.1 - 6.3e-40 136.0 0.0 1.3e-39 135.0 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 EDO17258.1 - 6.5e-14 52.1 1.4 6.5e-14 52.1 1.4 2.2 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EDO17258.1 - 0.00023 21.2 0.1 0.0052 16.9 0.1 2.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D4 PF14578.6 EDO17258.1 - 1.1 9.3 6.1 0.088 12.7 0.5 2.1 3 0 0 3 3 3 0 Elongation factor Tu domain 4 Mad3_BUB1_I PF08311.12 EDO17260.1 - 1.5e-39 134.8 1.6 3.8e-39 133.5 1.6 1.7 1 0 0 1 1 1 1 Mad3/BUB1 homology region 1 Mad3_BUB1_II PF08171.11 EDO17260.1 - 7.2e-28 96.6 2.7 8.3e-27 93.2 0.3 3.1 2 0 0 2 2 2 1 Mad3/BUB1 homology region 2 Pkinase PF00069.25 EDO17260.1 - 1.3e-18 67.3 0.0 2.7e-18 66.3 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Mad3_BUB1_I_2 PF17014.5 EDO17260.1 - 7e-05 22.9 5.4 7e-05 22.9 5.4 2.5 2 0 0 2 2 2 1 Putative Mad3/BUB1 like region 1 protein Pkinase_Tyr PF07714.17 EDO17260.1 - 0.006 15.9 0.0 0.013 14.8 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDO17260.1 - 0.037 13.3 0.0 0.065 12.5 0.0 1.3 1 0 0 1 1 1 0 Kinase-like YojJ PF10372.9 EDO17260.1 - 0.046 13.8 3.9 0.91 9.7 0.1 3.5 3 0 0 3 3 3 0 Bacterial membrane-spanning protein N-terminus Trs65 PF12735.7 EDO17262.1 - 2.7e-29 102.6 14.4 3.6e-28 98.9 10.9 3.3 1 1 0 1 1 1 1 TRAPP trafficking subunit Trs65 Pox_A31 PF05771.11 EDO17262.1 - 0.00075 19.5 0.3 0.0084 16.1 0.0 2.5 2 0 0 2 2 2 1 Poxvirus A31 protein LRR_4 PF12799.7 EDO17262.1 - 3.4 8.2 9.9 8.1 7.0 0.3 4.4 3 1 0 3 3 3 0 Leucine Rich repeats (2 copies) Clathrin_lg_ch PF01086.17 EDO17263.1 - 7.8e-42 143.9 12.1 8.5e-42 143.8 12.1 1.0 1 0 0 1 1 1 1 Clathrin light chain Phosducin PF02114.16 EDO17263.1 - 0.037 13.0 6.9 0.066 12.1 6.9 1.5 1 1 0 1 1 1 0 Phosducin DUF4065 PF13274.6 EDO17263.1 - 1.2 10.1 8.1 1.2 10.0 3.8 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF4065) SH3_1 PF00018.28 EDO17265.1 - 1.1e-06 28.2 0.0 3.6e-06 26.5 0.0 2.0 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EDO17265.1 - 8.6e-06 25.5 0.1 2.7e-05 23.9 0.0 2.0 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.17 EDO17265.1 - 1.6e-05 24.5 0.1 4.5e-05 23.0 0.0 1.8 2 0 0 2 2 2 1 Variant SH3 domain PS_Dcarbxylase PF02666.15 EDO17267.1 - 2e-52 177.7 0.0 3.6e-52 176.8 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase C2 PF00168.30 EDO17267.1 - 9.5e-18 64.4 1.1 2.6e-12 46.9 0.1 2.9 3 0 0 3 3 3 2 C2 domain DNA_pol_E_B PF04042.16 EDO17268.1 - 2.1e-38 131.8 0.1 2.1e-38 131.8 0.1 1.5 2 0 0 2 2 2 1 DNA polymerase alpha/epsilon subunit B DNA_pol_D_N PF18018.1 EDO17268.1 - 1.1e-35 122.6 0.0 2.7e-35 121.3 0.0 1.7 2 0 0 2 2 2 1 DNA polymerase delta subunit OB-fold domain DUF3914 PF13053.6 EDO17268.1 - 0.012 15.9 0.1 0.027 14.8 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3914) Myb_DNA-bind_6 PF13921.6 EDO17268.1 - 0.12 12.6 1.1 0.51 10.6 0.4 2.2 2 0 0 2 2 2 0 Myb-like DNA-binding domain tRNA-synt_1g PF09334.11 EDO17269.1 - 1.8e-89 300.3 2.0 1.9e-87 293.6 2.0 2.2 1 1 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 EDO17269.1 - 8.6e-23 80.4 0.9 1.3e-10 40.2 0.0 4.0 2 1 1 3 3 3 3 tRNA synthetases class I (I, L, M and V) tRNA-synt_1e PF01406.19 EDO17269.1 - 1.3e-07 31.2 0.1 0.00036 20.0 0.0 2.4 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain tRNA-synt_1f PF01921.18 EDO17269.1 - 0.0042 16.0 0.0 0.0099 14.8 0.0 1.6 1 0 0 1 1 1 1 tRNA synthetases class I (K) InvH PF04741.12 EDO17269.1 - 0.11 12.4 0.1 0.3 11.0 0.1 1.7 1 0 0 1 1 1 0 InvH outer membrane lipoprotein Yip1 PF04893.17 EDO17270.1 - 3.9e-12 46.2 13.4 6e-12 45.6 13.4 1.3 1 0 0 1 1 1 1 Yip1 domain Cyclin_N PF00134.23 EDO17271.1 - 1.6e-23 82.9 1.1 3.4e-23 81.8 1.1 1.6 1 0 0 1 1 1 1 Cyclin, N-terminal domain ETF_QO PF05187.13 EDO17273.1 - 1.7e-44 150.2 0.3 3.4e-44 149.2 0.3 1.5 1 0 0 1 1 1 1 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S DAO PF01266.24 EDO17273.1 - 2.5e-09 37.2 2.2 2.3e-05 24.2 1.5 2.4 2 0 0 2 2 2 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EDO17273.1 - 3e-09 36.5 1.1 0.0002 20.6 1.2 2.1 2 0 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.6 EDO17273.1 - 6.7e-09 35.9 0.1 2.9e-08 33.8 0.1 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 EDO17273.1 - 9.3e-08 31.6 0.0 0.00017 20.9 0.1 2.2 2 0 0 2 2 2 2 Thi4 family Pyr_redox_2 PF07992.14 EDO17273.1 - 1.5e-06 27.7 0.1 7.1e-05 22.2 0.0 2.2 1 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 EDO17273.1 - 5.8e-05 22.5 0.4 0.00026 20.4 0.4 1.9 1 1 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 EDO17273.1 - 0.00013 20.8 0.9 0.00098 17.9 0.6 2.0 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox_3 PF13738.6 EDO17273.1 - 0.00014 21.3 0.4 0.00035 19.9 0.4 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EDO17273.1 - 0.00018 21.0 0.1 0.00028 20.4 0.1 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 EDO17273.1 - 0.0015 18.6 0.3 0.0029 17.6 0.3 1.4 1 0 0 1 1 1 1 FAD-NAD(P)-binding Pyr_redox PF00070.27 EDO17273.1 - 0.0032 18.0 0.6 3.4 8.3 0.0 2.8 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 EDO17273.1 - 0.013 14.3 0.9 0.05 12.5 0.2 2.0 2 0 0 2 2 2 0 Tryptophan halogenase Lycopene_cycl PF05834.12 EDO17273.1 - 0.018 14.1 0.5 0.026 13.6 0.5 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein Amino_oxidase PF01593.24 EDO17273.1 - 0.058 12.7 0.0 0.19 10.9 0.1 1.8 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase Fer4_7 PF12838.7 EDO17273.1 - 0.099 13.2 0.4 0.21 12.2 0.4 1.5 1 0 0 1 1 1 0 4Fe-4S dicluster domain Fer4_2 PF12797.7 EDO17273.1 - 0.13 12.5 0.6 0.31 11.2 0.6 1.7 1 0 0 1 1 1 0 4Fe-4S binding domain COPIIcoated_ERV PF07970.12 EDO17274.1 - 2.9e-78 262.7 0.3 3.6e-78 262.4 0.3 1.1 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 EDO17274.1 - 1.4e-26 92.7 0.0 2.5e-26 91.9 0.0 1.5 1 0 0 1 1 1 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) PX PF00787.24 EDO17275.1 - 2.1e-23 82.5 0.1 2.7e-23 82.1 0.1 1.2 1 0 0 1 1 1 1 PX domain Histone PF00125.24 EDO17276.1 - 7.7e-23 81.3 0.0 9.5e-23 81.0 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EDO17276.1 - 4e-21 75.1 1.5 6.9e-21 74.3 1.5 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-X PF09415.10 EDO17276.1 - 0.015 15.6 0.2 0.035 14.4 0.2 1.6 1 0 0 1 1 1 0 CENP-S associating Centromere protein X TAFII28 PF04719.14 EDO17276.1 - 0.016 15.3 0.1 0.025 14.7 0.1 1.3 1 0 0 1 1 1 0 hTAFII28-like protein conserved region TAF PF02969.17 EDO17276.1 - 0.034 14.3 0.7 0.059 13.6 0.7 1.5 1 0 0 1 1 1 0 TATA box binding protein associated factor (TAF) DUF3791 PF12668.7 EDO17276.1 - 0.058 13.5 0.0 0.11 12.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3791) DUF3453 PF11935.8 EDO17277.1 - 3.1e-59 200.3 3.0 7.5e-59 199.1 3.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF3453) GCV_H PF01597.19 EDO17278.1 - 7.2e-45 151.8 0.3 8.6e-45 151.6 0.3 1.1 1 0 0 1 1 1 1 Glycine cleavage H-protein Biotin_lipoyl PF00364.22 EDO17278.1 - 0.02 14.7 0.1 0.099 12.5 0.1 1.9 2 0 0 2 2 2 0 Biotin-requiring enzyme eIF2A PF08662.11 EDO17279.1 - 5e-25 88.5 0.9 1.3e-22 80.7 0.5 3.6 2 1 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A RRM_1 PF00076.22 EDO17279.1 - 2.1e-05 24.2 0.1 4.7e-05 23.1 0.1 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) IKI3 PF04762.12 EDO17279.1 - 0.0043 15.1 0.2 0.012 13.6 0.2 1.7 1 1 1 2 2 2 1 IKI3 family Coatomer_WDAD PF04053.14 EDO17279.1 - 0.011 14.8 0.1 0.53 9.3 0.0 2.6 1 1 1 2 2 2 0 Coatomer WD associated region Proteasome PF00227.26 EDO17280.1 - 2.2e-50 170.8 0.0 2.9e-50 170.4 0.0 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EDO17280.1 - 5.7e-12 45.1 0.0 5.7e-12 45.1 0.0 2.1 3 0 0 3 3 3 1 Proteasome subunit A N-terminal signature DLH PF01738.18 EDO17281.1 - 6.8e-34 117.3 0.1 7.8e-34 117.1 0.1 1.0 1 0 0 1 1 1 1 Dienelactone hydrolase family BAAT_C PF08840.11 EDO17281.1 - 0.07 13.0 0.1 0.16 11.9 0.1 1.6 1 1 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal Hydrolase_4 PF12146.8 EDO17281.1 - 0.14 11.4 0.0 3.9 6.7 0.0 2.3 2 1 0 2 2 2 0 Serine aminopeptidase, S33 Zn_clus PF00172.18 EDO17282.1 - 1.5e-10 41.1 11.8 2.5e-10 40.3 11.8 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain AdoHcyase PF05221.17 EDO17282.1 - 0.051 12.7 0.2 0.1 11.7 0.2 1.4 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase Ctr PF04145.15 EDO17282.1 - 0.14 12.8 0.1 0.14 12.8 0.1 2.1 2 0 0 2 2 2 0 Ctr copper transporter family DUF4834 PF16118.5 EDO17282.1 - 5.4 8.0 7.0 1.2 10.1 0.5 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) AMP-binding PF00501.28 EDO17283.1 - 6.3e-89 298.5 0.0 7.6e-89 298.2 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EDO17283.1 - 3.1e-22 79.3 1.6 9.5e-22 77.8 0.1 2.5 3 0 0 3 3 3 1 AMP-binding enzyme C-terminal domain ACAS_N PF16177.5 EDO17283.1 - 9e-16 57.5 0.9 2.3e-15 56.2 0.9 1.8 1 0 0 1 1 1 1 Acetyl-coenzyme A synthetase N-terminus Ribosomal_L7Ae PF01248.26 EDO17284.1 - 5.9e-22 77.2 0.8 7.4e-22 76.9 0.8 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Kelch_3 PF13415.6 EDO17285.1 - 3.6e-07 30.3 0.5 0.01 16.1 0.0 5.3 7 0 0 7 7 7 2 Galactose oxidase, central domain Kelch_6 PF13964.6 EDO17285.1 - 1.7e-05 24.9 6.4 4 7.9 0.1 5.7 6 0 0 6 6 6 3 Kelch motif Kelch_4 PF13418.6 EDO17285.1 - 3.3e-05 23.8 7.2 0.027 14.5 0.1 5.1 5 0 0 5 5 5 1 Galactose oxidase, central domain Kelch_5 PF13854.6 EDO17285.1 - 0.00012 22.0 12.2 0.26 11.3 0.1 5.2 6 0 0 6 6 6 2 Kelch motif Kelch_1 PF01344.25 EDO17285.1 - 0.0009 18.8 2.4 2.1 8.0 0.0 3.9 3 0 0 3 3 3 2 Kelch motif LRR_9 PF14580.6 EDO17287.1 - 0.065 12.7 23.1 0.27 10.7 4.3 3.9 1 1 1 3 3 3 0 Leucine-rich repeat DUF3458 PF11940.8 EDO17287.1 - 0.12 12.8 0.5 0.36 11.3 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3458) Ig-like fold LRR_6 PF13516.6 EDO17287.1 - 0.34 11.1 17.4 3 8.1 0.1 6.5 7 0 0 7 7 7 0 Leucine Rich repeat LRR_8 PF13855.6 EDO17287.1 - 0.43 10.4 38.5 1.3 8.8 0.4 6.8 2 1 6 8 8 8 0 Leucine rich repeat LRR_4 PF12799.7 EDO17287.1 - 2.2 8.8 67.2 0.043 14.3 3.9 8.9 6 1 4 11 11 11 0 Leucine Rich repeats (2 copies) Aldedh PF00171.22 EDO17288.1 - 9e-179 594.8 0.7 1e-178 594.6 0.7 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.11 EDO17288.1 - 0.036 13.5 0.0 2.8 7.3 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1487) Calreticulin PF00262.18 EDO17289.1 - 2.5e-123 411.6 13.1 3.2e-123 411.2 13.1 1.1 1 0 0 1 1 1 1 Calreticulin family ELFV_dehydrog PF00208.21 EDO17290.1 - 1.6e-82 276.9 3.3 1.9e-82 276.7 3.3 1.1 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase ELFV_dehydrog_N PF02812.18 EDO17290.1 - 2.4e-47 160.1 0.0 4.5e-47 159.2 0.0 1.5 1 0 0 1 1 1 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain AbiJ_NTD4 PF18863.1 EDO17290.1 - 0.14 12.6 0.1 0.26 11.8 0.1 1.4 1 0 0 1 1 1 0 AbiJ N-terminal domain 4 Flavodoxin_2 PF02525.17 EDO17291.1 - 3.3e-54 183.6 0.0 4e-54 183.3 0.0 1.0 1 0 0 1 1 1 1 Flavodoxin-like fold FMN_red PF03358.15 EDO17291.1 - 1.4e-13 50.9 0.0 3.3e-13 49.7 0.0 1.6 1 1 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_4 PF12682.7 EDO17291.1 - 0.034 13.9 0.1 0.067 12.9 0.1 1.5 1 0 0 1 1 1 0 Flavodoxin Fungal_trans_2 PF11951.8 EDO17292.1 - 2.4e-94 316.3 1.3 3.6e-94 315.7 1.3 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDO17292.1 - 7.6e-11 41.9 7.4 1.4e-10 41.1 7.4 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PQ-loop PF04193.14 EDO17293.1 - 7.6e-19 67.2 2.4 7.6e-19 67.2 2.4 3.0 3 0 0 3 3 3 1 PQ loop repeat GT87 PF09594.10 EDO17293.1 - 0.01 15.6 6.4 0.013 15.2 1.9 2.1 2 0 0 2 2 2 0 Glycosyltransferase family 87 Bestrophin PF01062.21 EDO17293.1 - 3 7.1 7.9 0.084 12.3 0.6 2.0 2 1 1 3 3 3 0 Bestrophin, RFP-TM, chloride channel DUF5325 PF17259.2 EDO17293.1 - 5.3 7.0 8.7 7.8 6.5 1.0 2.8 3 0 0 3 3 3 0 Family of unknown function (DUF5325) DUF805 PF05656.14 EDO17293.1 - 8.4 6.9 9.4 1.4e+03 -0.3 9.4 2.4 1 1 0 1 1 1 0 Protein of unknown function (DUF805) GCP_N_terminal PF17681.1 EDO17294.1 - 1.5e-38 133.1 1.2 1.5e-38 133.1 1.2 2.2 2 0 0 2 2 2 1 Gamma tubulin complex component N-terminal GCP_C_terminal PF04130.13 EDO17294.1 - 1.7e-13 50.7 8.2 1.7e-13 50.7 8.2 1.9 2 0 0 2 2 2 1 Gamma tubulin complex component C-terminal Proteasome PF00227.26 EDO17295.1 - 4.1e-55 186.2 0.1 5.4e-55 185.8 0.1 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EDO17295.1 - 2e-12 46.6 0.0 5.3e-12 45.2 0.0 1.8 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Bromodomain PF00439.25 EDO17296.1 - 5.4e-27 93.7 2.3 1.3e-26 92.5 2.3 1.7 1 0 0 1 1 1 1 Bromodomain Acetyltransf_1 PF00583.25 EDO17296.1 - 7.4e-09 35.9 0.0 1.6e-08 34.7 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EDO17296.1 - 3e-06 27.2 0.0 6.8e-06 26.0 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EDO17296.1 - 0.00085 19.7 0.1 0.0017 18.8 0.1 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain NMD3 PF04981.13 EDO17297.1 - 1.1e-82 277.1 1.7 1.7e-82 276.5 1.7 1.3 1 0 0 1 1 1 1 NMD3 family HypA PF01155.19 EDO17297.1 - 0.49 10.4 5.1 11 6.0 1.6 2.6 2 1 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DZR PF12773.7 EDO17297.1 - 0.56 10.3 6.9 11 6.2 6.9 2.6 1 1 0 1 1 1 0 Double zinc ribbon Hist_rich_Ca-bd PF10529.9 EDO17297.1 - 2.5 8.4 6.4 6.8 7.1 6.4 1.7 1 0 0 1 1 1 0 Histidine-rich Calcium-binding repeat region DEAD PF00270.29 EDO17298.1 - 1.7e-43 148.4 0.1 3.9e-43 147.2 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDO17298.1 - 1.4e-31 109.1 0.1 7.6e-31 106.7 0.1 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDO17298.1 - 0.0026 17.8 0.2 0.01 15.8 0.0 2.1 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit Gcd10p PF04189.13 EDO17299.1 - 0.0048 16.1 0.5 0.0055 15.9 0.5 1.2 1 0 0 1 1 1 1 Gcd10p family RRM_1 PF00076.22 EDO17300.1 - 5.6e-30 103.0 0.2 1.4e-11 44.0 0.0 4.9 5 0 0 5 5 5 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNA_bind PF08675.11 EDO17300.1 - 0.0065 16.5 0.2 0.69 10.0 0.0 3.5 3 0 0 3 3 3 1 RNA binding domain RRM_7 PF16367.5 EDO17300.1 - 0.082 13.0 0.6 43 4.3 0.0 3.7 4 0 0 4 4 4 0 RNA recognition motif HSF_DNA-bind PF00447.17 EDO17301.1 - 4.6e-23 81.7 0.5 9.9e-23 80.6 0.5 1.6 1 0 0 1 1 1 1 HSF-type DNA-binding Mito_carr PF00153.27 EDO17302.1 - 3.4e-57 190.4 3.9 7.8e-20 70.6 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein NBP1 PF08537.10 EDO17303.1 - 0.022 14.2 1.3 0.028 13.9 1.3 1.1 1 0 0 1 1 1 0 Fungal Nap binding protein NBP1 TPP_enzyme_N PF02776.18 EDO17304.1 - 1.4e-24 86.7 0.0 2.3e-24 85.9 0.0 1.3 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.22 EDO17304.1 - 4.2e-17 62.2 0.0 1e-16 60.9 0.0 1.6 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.21 EDO17304.1 - 1.9e-15 57.0 0.0 4.1e-15 55.9 0.0 1.6 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain Complex1_LYR PF05347.15 EDO17305.1 - 1.5e-13 50.6 0.0 2e-13 50.2 0.0 1.2 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 EDO17305.1 - 0.0068 17.1 0.1 0.0079 16.9 0.1 1.2 1 0 0 1 1 1 1 Complex1_LYR-like RhoGAP PF00620.27 EDO17306.1 - 1.8e-39 135.0 0.4 4.2e-39 133.8 0.4 1.6 1 0 0 1 1 1 1 RhoGAP domain LIM PF00412.22 EDO17306.1 - 6.5e-15 55.1 31.4 5.7e-09 36.1 10.4 2.5 2 0 0 2 2 2 2 LIM domain APG6_N PF17675.1 EDO17306.1 - 0.062 13.8 1.2 0.22 12.0 1.2 2.0 1 0 0 1 1 1 0 Apg6 coiled-coil region LSM PF01423.22 EDO17307.1 - 7e-17 60.9 0.0 8.1e-17 60.7 0.0 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EDO17307.1 - 0.00062 19.9 0.0 0.00073 19.6 0.0 1.2 1 0 0 1 1 1 1 Ataxin 2 SM domain LSM14 PF12701.7 EDO17307.1 - 0.00096 19.2 0.0 0.0012 18.9 0.0 1.2 1 0 0 1 1 1 1 Scd6-like Sm domain Hfq PF17209.3 EDO17307.1 - 0.13 11.9 0.0 0.2 11.3 0.0 1.3 1 0 0 1 1 1 0 Hfq protein Pyr_redox_2 PF07992.14 EDO17308.1 - 2.4e-08 33.6 0.0 5e-06 26.0 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EDO17308.1 - 2.2e-05 24.6 0.0 5.2e-05 23.4 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 EDO17308.1 - 0.00082 19.4 0.0 0.0036 17.3 0.0 2.1 2 0 0 2 2 2 1 FAD-NAD(P)-binding DAO PF01266.24 EDO17308.1 - 0.02 14.5 0.0 0.029 14.0 0.0 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase Shikimate_DH PF01488.20 EDO17308.1 - 0.033 14.3 0.0 16 5.5 0.0 3.3 3 0 0 3 3 3 0 Shikimate / quinate 5-dehydrogenase NAD_binding_7 PF13241.6 EDO17308.1 - 0.094 13.2 0.0 5.2 7.6 0.0 2.6 2 1 0 2 2 2 0 Putative NAD(P)-binding Lipase_GDSL_2 PF13472.6 EDO17309.1 - 4.5e-19 69.5 0.0 7e-19 68.9 0.0 1.3 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 EDO17309.1 - 3.5e-09 36.9 0.0 2.1e-08 34.4 0.0 2.1 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase DUF1574 PF07611.11 EDO17309.1 - 0.066 12.5 0.2 0.12 11.7 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1574) AP_endonuc_2 PF01261.24 EDO17309.1 - 0.19 11.1 0.0 0.26 10.7 0.0 1.2 1 0 0 1 1 1 0 Xylose isomerase-like TIM barrel BCS1_N PF08740.11 EDO17310.1 - 3.4e-44 151.1 0.0 4.7e-44 150.6 0.0 1.2 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.29 EDO17310.1 - 6.4e-23 81.6 0.0 1.1e-22 80.8 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 EDO17310.1 - 0.00069 19.4 0.0 0.0013 18.5 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EDO17310.1 - 0.00093 19.6 0.0 0.0034 17.8 0.0 1.8 1 1 0 1 1 1 1 AAA ATPase domain DUF815 PF05673.13 EDO17310.1 - 0.0013 18.0 0.0 0.0024 17.1 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_18 PF13238.6 EDO17310.1 - 0.0021 18.6 0.0 0.0053 17.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_7 PF12775.7 EDO17310.1 - 0.003 17.1 0.0 0.0071 15.9 0.0 1.6 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_33 PF13671.6 EDO17310.1 - 0.0034 17.6 0.0 0.0064 16.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain NACHT PF05729.12 EDO17310.1 - 0.0034 17.3 0.0 0.31 10.9 0.0 3.1 2 1 1 3 3 3 1 NACHT domain AAA_5 PF07728.14 EDO17310.1 - 0.0038 17.2 0.0 0.019 14.9 0.0 2.1 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) ABC_tran PF00005.27 EDO17310.1 - 0.0063 17.0 0.0 0.014 15.9 0.0 1.5 1 0 0 1 1 1 1 ABC transporter AAA_24 PF13479.6 EDO17310.1 - 0.01 15.6 0.0 0.032 14.0 0.0 1.8 2 0 0 2 2 2 0 AAA domain Rad17 PF03215.15 EDO17310.1 - 0.019 14.9 0.0 0.45 10.4 0.0 2.4 1 1 1 2 2 2 0 Rad17 P-loop domain RNA_helicase PF00910.22 EDO17310.1 - 0.025 14.9 0.0 0.066 13.6 0.0 1.8 1 0 0 1 1 1 0 RNA helicase AAA_29 PF13555.6 EDO17310.1 - 0.029 14.1 0.0 0.064 13.0 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_21 PF13304.6 EDO17310.1 - 0.03 14.1 0.0 0.069 12.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 EDO17310.1 - 0.047 14.0 0.0 0.12 12.6 0.0 1.7 1 1 0 1 1 1 0 AAA domain ATPase PF06745.13 EDO17310.1 - 0.048 13.0 0.0 0.088 12.1 0.0 1.4 1 0 0 1 1 1 0 KaiC RcnB PF11776.8 EDO17310.1 - 0.066 13.3 0.0 0.18 11.9 0.0 1.6 1 0 0 1 1 1 0 Nickel/cobalt transporter regulator TsaE PF02367.17 EDO17310.1 - 0.1 12.6 0.0 0.33 11.0 0.0 1.8 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_11 PF13086.6 EDO17310.1 - 0.11 12.3 0.0 0.17 11.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain Gram_pos_anchor PF00746.21 EDO17310.1 - 0.12 12.3 0.7 0.36 10.8 0.7 1.7 1 0 0 1 1 1 0 LPXTG cell wall anchor motif ATPase_2 PF01637.18 EDO17310.1 - 0.13 12.1 0.0 0.26 11.2 0.0 1.5 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_17 PF13207.6 EDO17310.1 - 0.19 12.2 0.0 0.42 11.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain DUF3439 PF11921.8 EDO17311.1 - 3.2 7.7 7.8 0.15 12.1 0.5 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF3439) YTH PF04146.15 EDO17312.1 - 2.3e-34 118.7 0.1 4.8e-34 117.7 0.1 1.5 1 0 0 1 1 1 1 YT521-B-like domain DUF4452 PF14618.6 EDO17312.1 - 0.17 11.8 2.7 0.28 11.0 2.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4452) COQ7 PF03232.13 EDO17313.1 - 5e-74 247.7 0.0 6.1e-74 247.5 0.0 1.1 1 0 0 1 1 1 1 Ubiquinone biosynthesis protein COQ7 EF-hand_1 PF00036.32 EDO17314.1 - 3.4e-26 88.8 6.8 1e-07 31.0 0.6 4.3 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.6 EDO17314.1 - 2.8e-24 85.4 7.0 9.6e-18 64.4 0.5 3.0 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EDO17314.1 - 1.1e-22 78.0 5.6 2.8e-06 26.8 0.1 4.7 5 0 0 5 5 5 3 EF-hand domain EF-hand_5 PF13202.6 EDO17314.1 - 3.9e-19 67.2 3.0 4e-05 22.9 0.2 3.8 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.6 EDO17314.1 - 1.9e-18 66.0 8.2 6.3e-09 35.6 0.1 3.8 2 1 2 4 4 4 3 EF-hand domain pair EF-hand_4 PF12763.7 EDO17314.1 - 4.1e-05 23.5 5.2 0.45 10.5 0.1 3.4 1 1 2 3 3 3 3 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 EDO17314.1 - 0.00066 20.0 1.7 0.13 12.6 0.3 3.3 1 1 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.6 EDO17314.1 - 0.00069 19.9 0.4 0.013 15.8 0.1 2.4 2 1 0 2 2 2 1 EF-hand domain S10_plectin PF03501.15 EDO17314.1 - 0.025 14.6 0.0 0.044 13.8 0.0 1.4 1 0 0 1 1 1 0 Plectin/S10 domain EF-hand_2 PF09068.11 EDO17314.1 - 0.1 12.8 0.0 12 6.1 0.0 2.2 2 0 0 2 2 2 0 EF hand UCH PF00443.29 EDO17315.1 - 4e-54 183.8 2.2 8.6e-54 182.7 2.2 1.6 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase RPT PF13446.6 EDO17315.1 - 1.6e-46 156.0 12.9 1.3e-16 60.2 0.2 5.1 4 0 0 4 4 4 4 A repeated domain in UCH-protein UCH_1 PF13423.6 EDO17315.1 - 0.00025 20.8 1.2 0.00025 20.8 1.2 3.0 3 1 0 3 3 3 1 Ubiquitin carboxyl-terminal hydrolase GIT_CC PF16559.5 EDO17315.1 - 0.14 12.0 1.1 1.8 8.5 0.0 2.9 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor GPP34 PF05719.11 EDO17316.1 - 4.8e-55 186.8 0.0 5.6e-55 186.5 0.0 1.0 1 0 0 1 1 1 1 Golgi phosphoprotein 3 (GPP34) Glyco_hydro_18 PF00704.28 EDO17317.1 - 1.2e-68 232.1 7.0 1.5e-68 231.8 7.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 RNA_pol_3_Rpc31 PF11705.8 EDO17317.1 - 0.019 15.2 9.1 0.032 14.5 9.1 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 CENP-B_dimeris PF09026.10 EDO17317.1 - 0.2 12.1 12.8 0.53 10.7 12.8 1.7 1 0 0 1 1 1 0 Centromere protein B dimerisation domain NOA36 PF06524.12 EDO17317.1 - 0.47 9.7 15.1 0.81 9.0 15.1 1.3 1 0 0 1 1 1 0 NOA36 protein RXT2_N PF08595.11 EDO17317.1 - 0.7 9.9 5.9 1.4 9.0 5.9 1.4 1 0 0 1 1 1 0 RXT2-like, N-terminal CDC45 PF02724.14 EDO17317.1 - 0.84 7.8 4.7 1.3 7.3 4.7 1.2 1 0 0 1 1 1 0 CDC45-like protein FAM176 PF14851.6 EDO17317.1 - 1.1 8.9 3.3 3.3 7.4 3.3 1.7 1 0 0 1 1 1 0 FAM176 family Cwf_Cwc_15 PF04889.12 EDO17317.1 - 2.7 7.7 12.5 5 6.8 12.5 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DUF2457 PF10446.9 EDO17317.1 - 5.2 6.1 14.8 7.8 5.5 14.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) DUF4611 PF15387.6 EDO17317.1 - 7.5 6.8 10.2 16 5.8 10.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) DNA_pol_phi PF04931.13 EDO17317.1 - 9.4 4.2 12.3 16 3.4 12.3 1.3 1 0 0 1 1 1 0 DNA polymerase phi Leo1 PF04004.13 EDO17318.1 - 2.4e-45 154.4 0.0 2.4e-45 154.4 0.0 2.6 3 0 0 3 3 3 1 Leo1-like protein Profilin PF00235.19 EDO17319.1 - 1e-45 155.1 0.1 1.1e-45 155.0 0.1 1.0 1 0 0 1 1 1 1 Profilin Aldo_ket_red PF00248.21 EDO17321.1 - 5.1e-44 150.6 0.0 4.7e-42 144.2 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family Kei1 PF08552.11 EDO17322.1 - 8.9e-37 126.8 17.8 1.3e-30 106.7 9.8 2.1 1 1 1 2 2 2 2 Inositolphosphorylceramide synthase subunit Kei1 RIO1 PF01163.22 EDO17323.1 - 2.3e-70 236.0 0.4 2.3e-70 236.0 0.4 2.6 3 1 0 3 3 3 1 RIO1 family APH PF01636.23 EDO17323.1 - 0.11 12.5 0.0 5.5 6.8 0.0 2.2 2 0 0 2 2 2 0 Phosphotransferase enzyme family CobT PF06213.12 EDO17323.1 - 2.5 7.4 26.7 4.6 6.6 26.7 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT RR_TM4-6 PF06459.12 EDO17323.1 - 4.3 7.1 16.4 9.1 6.0 16.4 1.5 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CDC45 PF02724.14 EDO17323.1 - 5.6 5.1 34.5 0.22 9.8 28.9 1.4 2 0 0 2 2 2 0 CDC45-like protein BUD22 PF09073.10 EDO17323.1 - 8.4 5.6 34.8 0.7 9.2 29.8 1.7 2 0 0 2 2 2 0 BUD22 Nop14 PF04147.12 EDO17323.1 - 9.9 4.2 38.8 0.16 10.2 32.1 1.4 2 0 0 2 2 2 0 Nop14-like family WD40 PF00400.32 EDO17324.1 - 4.3e-30 103.3 5.7 2.6e-05 24.9 0.0 6.5 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDO17324.1 - 1.3e-11 44.6 0.0 0.02 15.2 0.0 4.4 2 1 1 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EDO17324.1 - 0.023 13.7 0.0 0.28 10.1 0.0 2.3 2 0 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein bMG1 PF17970.1 EDO17324.1 - 0.065 13.3 0.0 0.13 12.3 0.0 1.4 1 0 0 1 1 1 0 Bacterial Alpha-2-macroglobulin MG1 domain PD40 PF07676.12 EDO17324.1 - 0.068 13.1 0.3 0.75 9.8 0.0 2.6 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat AAA PF00004.29 EDO17325.1 - 4.7e-41 140.3 0.2 1.2e-40 139.0 0.0 1.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 EDO17325.1 - 1.7e-19 69.5 0.2 3.5e-19 68.5 0.2 1.6 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_lid_3 PF17862.1 EDO17325.1 - 1.2e-08 34.6 0.0 3e-08 33.3 0.0 1.7 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 EDO17325.1 - 1.4e-05 25.6 0.1 0.014 15.8 0.0 2.5 1 1 1 2 2 2 2 AAA ATPase domain AAA_2 PF07724.14 EDO17325.1 - 4.6e-05 23.6 0.5 0.00022 21.4 0.0 2.3 3 1 0 3 3 3 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 EDO17325.1 - 6.8e-05 22.9 0.1 0.00036 20.6 0.1 2.2 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 EDO17325.1 - 0.00075 19.3 0.0 0.0019 18.0 0.0 1.7 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EDO17325.1 - 0.00083 19.6 0.2 0.078 13.3 0.0 2.6 1 1 1 2 2 2 1 AAA domain AAA_33 PF13671.6 EDO17325.1 - 0.0063 16.7 0.1 0.024 14.8 0.0 2.1 2 0 0 2 2 2 1 AAA domain DUF1192 PF06698.11 EDO17325.1 - 0.0072 16.4 0.7 0.019 15.0 0.7 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1192) PhoH PF02562.16 EDO17325.1 - 0.0085 15.6 0.2 0.054 12.9 0.1 2.1 2 0 0 2 2 2 1 PhoH-like protein Mg_chelatase PF01078.21 EDO17325.1 - 0.016 14.6 0.1 0.043 13.2 0.1 1.7 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI DUF815 PF05673.13 EDO17325.1 - 0.016 14.4 0.0 0.032 13.4 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF815) IstB_IS21 PF01695.17 EDO17325.1 - 0.02 14.6 0.2 0.061 13.1 0.0 1.9 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_11 PF13086.6 EDO17325.1 - 0.025 14.4 0.5 0.28 10.9 0.0 2.2 2 0 0 2 2 2 0 AAA domain ThylakoidFormat PF11264.8 EDO17325.1 - 0.043 13.5 2.9 0.086 12.5 2.9 1.5 1 0 0 1 1 1 0 Thylakoid formation protein AAA_7 PF12775.7 EDO17325.1 - 0.045 13.3 0.0 0.12 11.9 0.0 1.6 1 1 0 1 1 1 0 P-loop containing dynein motor region AAA_19 PF13245.6 EDO17325.1 - 0.049 14.0 0.2 0.16 12.3 0.0 2.0 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.27 EDO17325.1 - 0.11 13.0 0.4 20 5.7 0.0 2.7 2 0 0 2 2 2 0 ABC transporter AAA_24 PF13479.6 EDO17325.1 - 0.13 12.0 0.8 0.31 10.7 0.1 2.2 2 1 0 2 2 2 0 AAA domain JIP_LZII PF16471.5 EDO17325.1 - 0.29 11.3 4.7 0.86 9.8 4.7 1.8 1 0 0 1 1 1 0 JNK-interacting protein leucine zipper II TolA_bind_tri PF16331.5 EDO17325.1 - 0.92 9.6 8.7 1.5 9.0 6.3 2.4 2 0 0 2 2 2 0 TolA binding protein trimerisation Fez1 PF06818.15 EDO17325.1 - 1.8 9.0 7.3 1.1 9.7 3.4 2.2 2 1 0 2 2 2 0 Fez1 Abhydrolase_1 PF00561.20 EDO17327.1 - 2.4e-19 70.0 0.0 3.5e-19 69.4 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EDO17327.1 - 3.3e-07 31.1 0.0 7.5e-07 30.0 0.0 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EDO17327.1 - 2.7e-05 23.6 0.0 4.8e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Thioesterase PF00975.20 EDO17327.1 - 0.0044 17.2 0.0 0.0082 16.3 0.0 1.4 1 0 0 1 1 1 1 Thioesterase domain FSH1 PF03959.13 EDO17327.1 - 0.011 15.4 0.0 21 4.7 0.0 3.1 2 1 0 3 3 3 0 Serine hydrolase (FSH1) BAAT_C PF08840.11 EDO17327.1 - 0.13 12.2 0.0 0.26 11.2 0.0 1.5 1 0 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal Orf78 PF06024.12 EDO17328.1 - 0.0029 17.9 0.0 0.028 14.7 0.0 2.8 1 0 0 1 1 1 1 Orf78 (ac78) RIFIN PF02009.16 EDO17328.1 - 1.4 8.8 0.0 1.4 8.8 0.0 5.1 2 1 4 6 6 6 0 Rifin PWI PF01480.17 EDO17329.1 - 0.0019 18.4 1.4 0.0073 16.6 1.0 2.3 2 0 0 2 2 2 1 PWI domain PBP1_TM PF14812.6 EDO17329.1 - 0.032 14.6 2.5 0.13 12.7 2.5 2.0 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Ribosomal_60s PF00428.19 EDO17329.1 - 0.29 11.7 5.0 0.65 10.6 4.2 2.1 2 0 0 2 2 2 0 60s Acidic ribosomal protein HABP4_PAI-RBP1 PF04774.15 EDO17330.1 - 0.0039 18.0 0.2 0.0051 17.7 0.2 1.3 1 0 0 1 1 1 1 Hyaluronan / mRNA binding family CTP_transf_like PF01467.26 EDO17331.1 - 1.5e-25 90.1 0.2 7.1e-22 78.2 0.0 2.2 2 0 0 2 2 2 2 Cytidylyltransferase-like FAD_syn PF06574.12 EDO17331.1 - 0.02 14.8 0.1 3.5 7.5 0.0 2.5 2 0 0 2 2 2 0 FAD synthetase Tctex-1 PF03645.13 EDO17331.1 - 0.052 13.8 0.3 1.9 8.8 0.1 2.6 2 1 0 2 2 2 0 Tctex-1 family Prp18 PF02840.15 EDO17332.1 - 9.4e-29 100.3 0.7 9.4e-29 100.3 0.7 2.0 2 1 0 2 2 2 1 Prp18 domain UPF0147 PF03685.13 EDO17332.1 - 0.034 14.2 0.6 0.034 14.2 0.6 2.2 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0147) TFIIF_beta_N PF17683.1 EDO17333.1 - 2.3e-35 122.2 10.8 1.2e-34 119.9 10.8 2.1 1 1 0 1 1 1 1 TFIIF, beta subunit N-terminus TFIIF_beta PF02270.15 EDO17333.1 - 2e-27 95.1 0.7 4.5e-27 94.0 0.7 1.6 1 0 0 1 1 1 1 TFIIF, beta subunit HTH domain Adeno_E1B_19K PF01691.16 EDO17333.1 - 0.1 12.1 0.0 0.22 11.0 0.0 1.5 1 0 0 1 1 1 0 Adenovirus E1B 19K protein / small t-antigen UPF0242 PF06785.11 EDO17333.1 - 1.7 8.7 13.4 0.82 9.8 9.0 2.4 2 1 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Ribosomal_L38e PF01781.18 EDO17334.1 - 1.2e-26 92.5 2.3 1.4e-26 92.4 2.3 1.0 1 0 0 1 1 1 1 Ribosomal L38e protein family Pex24p PF06398.11 EDO17335.1 - 5.4e-41 140.8 9.4 7.9e-41 140.2 9.4 1.3 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin Cullin PF00888.22 EDO17336.1 - 1.3e-125 420.4 38.8 1.8e-125 420.0 38.8 1.2 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 EDO17336.1 - 3.1e-12 46.3 2.7 3.1e-12 46.3 2.7 3.0 3 0 0 3 3 3 1 Cullin protein neddylation domain DUF2935 PF11155.8 EDO17336.1 - 0.043 14.1 3.0 12 6.2 0.0 4.1 3 2 0 3 3 3 0 Domain of unknown function (DUF2935) SANT_DAMP1_like PF16282.5 EDO17337.1 - 1.2e-25 89.5 4.8 2.4e-20 72.5 1.0 3.0 2 0 0 2 2 2 2 SANT/Myb-like domain of DAMP1 TFIIA PF03153.13 EDO17337.1 - 0.0037 17.3 23.3 0.0037 17.3 23.3 2.1 2 1 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit AIP3 PF03915.13 EDO17338.1 - 1.9e-131 438.9 16.5 1.9e-131 438.9 16.5 2.8 2 1 1 3 3 3 1 Actin interacting protein 3 HSBP1 PF06825.12 EDO17338.1 - 0.051 13.4 2.7 0.11 12.4 0.2 2.8 3 0 0 3 3 3 0 Heat shock factor binding protein 1 MerR_2 PF13591.6 EDO17338.1 - 0.71 9.8 4.4 46 4.0 0.1 4.2 3 0 0 3 3 3 0 MerR HTH family regulatory protein Telomerase_RBD PF12009.8 EDO17339.1 - 1.8e-30 105.8 3.2 6.4e-30 104.0 3.2 2.1 1 0 0 1 1 1 1 Telomerase ribonucleoprotein complex - RNA binding domain RVT_1 PF00078.27 EDO17339.1 - 5.9e-08 32.5 7.9 4.6e-06 26.3 0.2 3.6 4 0 0 4 4 4 2 Reverse transcriptase (RNA-dependent DNA polymerase) Cnl2_NKP2 PF09447.10 EDO17340.1 - 0.00061 19.9 0.2 0.0021 18.2 0.0 2.0 1 1 0 1 1 1 1 Cnl2/NKP2 family protein Jnk-SapK_ap_N PF09744.9 EDO17340.1 - 0.044 14.0 3.4 0.067 13.4 3.4 1.4 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 Cep57_MT_bd PF06657.13 EDO17340.1 - 0.063 13.7 1.8 1.5 9.3 0.1 2.5 2 1 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 Prominin PF05478.11 EDO17340.1 - 0.095 10.6 4.6 0.099 10.6 4.6 1.1 1 0 0 1 1 1 0 Prominin Fe-S_assembly PF04384.13 EDO17340.1 - 0.11 13.2 1.2 0.19 12.3 0.2 2.0 2 0 0 2 2 2 0 Iron-sulphur cluster assembly OrsD PF12013.8 EDO17340.1 - 0.15 12.6 1.1 2.9 8.3 0.4 2.3 1 1 1 2 2 2 0 Orsellinic acid/F9775 biosynthesis cluster protein D SNF5 PF04855.12 EDO17341.1 - 2.5e-46 158.4 1.8 1.4e-27 97.1 0.0 3.2 2 2 1 3 3 3 2 SNF5 / SMARCB1 / INI1 EF1_GNE PF00736.19 EDO17342.1 - 1.2e-31 108.7 1.4 1.2e-31 108.7 1.4 1.7 2 0 0 2 2 2 1 EF-1 guanine nucleotide exchange domain EF-1_beta_acid PF10587.9 EDO17342.1 - 1.1e-12 48.2 4.1 1.1e-12 48.2 4.1 2.8 4 0 0 4 4 4 1 Eukaryotic elongation factor 1 beta central acidic region Vps8 PF12816.7 EDO17343.1 - 3.6e-54 183.3 9.8 1.3e-52 178.2 3.1 2.7 2 0 0 2 2 2 2 Golgi CORVET complex core vacuolar protein 8 zf-RING_2 PF13639.6 EDO17343.1 - 0.0062 16.8 2.0 0.0062 16.8 2.0 2.2 2 0 0 2 2 2 1 Ring finger domain zf-RING_UBOX PF13445.6 EDO17343.1 - 0.0064 16.5 2.7 0.023 14.7 2.7 1.9 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 EDO17343.1 - 0.025 14.4 8.0 0.082 12.8 8.0 2.0 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EDO17343.1 - 0.03 14.1 2.6 0.088 12.6 2.6 1.8 1 0 0 1 1 1 0 RING-like zinc finger WD40 PF00400.32 EDO17343.1 - 0.043 14.7 2.2 0.45 11.5 0.2 3.7 3 0 0 3 3 2 0 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDO17343.1 - 0.11 12.9 0.4 3.8 7.9 0.0 3.2 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain Imm6 PF14434.6 EDO17343.1 - 1.6 8.7 8.5 1.1 9.2 0.2 4.4 4 1 1 5 5 5 0 Immunity protein Imm6 zf-RING_5 PF14634.6 EDO17343.1 - 2.6 8.1 10.5 15 5.6 10.7 2.2 1 1 1 2 2 2 0 zinc-RING finger domain zf-rbx1 PF12678.7 EDO17343.1 - 2.9 8.3 9.4 2.3 8.6 6.4 2.5 2 0 0 2 2 2 0 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 EDO17343.1 - 5 7.0 11.1 0.066 13.1 3.3 2.0 2 0 0 2 2 1 0 Zinc finger, C3HC4 type (RING finger) PHD PF00628.29 EDO17343.1 - 8.3 6.4 8.4 0.66 9.9 2.1 2.2 2 0 0 2 2 2 0 PHD-finger N6-adenineMlase PF10237.9 EDO17344.1 - 1e-56 191.1 0.3 1.9e-56 190.3 0.3 1.4 1 0 0 1 1 1 1 Probable N6-adenine methyltransferase Mac PF12464.8 EDO17344.1 - 0.0098 16.1 0.8 0.023 14.9 0.8 1.6 1 0 0 1 1 1 1 Maltose acetyltransferase Adap_comp_sub PF00928.21 EDO17345.1 - 2.3e-89 299.3 1.6 3.4e-89 298.7 1.6 1.3 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 EDO17345.1 - 3e-06 27.2 1.9 4.6e-06 26.6 1.3 1.6 1 1 0 1 1 1 1 Clathrin adaptor complex small chain muHD PF10291.9 EDO17345.1 - 0.001 18.6 0.2 0.011 15.2 0.0 2.3 3 0 0 3 3 3 1 Muniscin C-terminal mu homology domain AhpC-TSA PF00578.21 EDO17346.1 - 7.8e-28 96.9 0.3 2.4e-27 95.3 0.0 1.7 2 0 0 2 2 2 1 AhpC/TSA family Redoxin PF08534.10 EDO17346.1 - 6.4e-18 64.9 0.0 1.2e-17 63.9 0.0 1.5 2 0 0 2 2 2 1 Redoxin AhpC-TSA_2 PF13911.6 EDO17346.1 - 0.032 14.4 0.0 0.051 13.7 0.0 1.3 1 0 0 1 1 1 0 AhpC/TSA antioxidant enzyme DUF1644 PF07800.12 EDO17346.1 - 0.11 12.6 1.6 0.18 11.9 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1644) Amino_oxidase PF01593.24 EDO17347.1 - 1.2e-14 54.5 0.0 1.4e-14 54.3 0.0 1.1 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EDO17347.1 - 1e-12 48.1 0.0 2.8e-12 46.7 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 EDO17347.1 - 0.00024 20.4 0.0 0.0005 19.4 0.0 1.4 1 0 0 1 1 1 1 Thi4 family Pyr_redox_2 PF07992.14 EDO17347.1 - 0.00026 20.3 0.0 0.023 13.9 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EDO17347.1 - 0.00026 21.0 0.0 0.087 12.8 0.0 2.4 2 0 0 2 2 2 2 FAD-NAD(P)-binding DAO PF01266.24 EDO17347.1 - 0.00031 20.4 0.0 0.0045 16.6 0.0 2.0 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 EDO17347.1 - 0.00048 20.6 0.1 0.064 13.8 0.0 2.9 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EDO17347.1 - 0.021 14.0 0.2 12 4.9 0.0 3.0 3 0 0 3 3 3 0 L-lysine 6-monooxygenase (NADPH-requiring) Mqo PF06039.15 EDO17347.1 - 0.033 12.7 0.1 0.21 10.1 0.0 2.2 2 0 0 2 2 2 0 Malate:quinone oxidoreductase (Mqo) HMG_box PF00505.19 EDO17348.1 - 1.1e-13 51.3 5.2 8.7e-13 48.5 5.2 2.4 1 1 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EDO17348.1 - 0.00018 22.0 0.7 0.00079 20.0 0.7 2.0 1 1 0 1 1 1 1 HMG-box domain Macoilin PF09726.9 EDO17348.1 - 9.6 4.6 11.7 18 3.7 11.7 1.4 1 1 0 1 1 1 0 Macoilin family Proteasome PF00227.26 EDO17349.1 - 1.2e-44 152.1 0.0 1.4e-44 151.9 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EDO17349.1 - 6.6e-12 44.9 0.1 1.3e-11 43.9 0.1 1.5 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature PikAIV_N PF18605.1 EDO17349.1 - 0.053 13.1 0.0 0.14 11.7 0.0 1.7 1 0 0 1 1 1 0 Narbonolide/10-deoxymethynolide synthase PikA4 N-terminal domain ELP6 PF09807.9 EDO17350.1 - 0.029 13.8 0.0 0.039 13.4 0.0 1.2 1 0 0 1 1 1 0 Elongation complex protein 6 RAC_head PF16717.5 EDO17351.1 - 4.7e-22 78.8 6.5 4.7e-22 78.8 6.5 3.2 2 1 0 2 2 2 1 Ribosome-associated complex head domain DnaJ PF00226.31 EDO17351.1 - 1.8e-15 56.8 0.1 5.6e-15 55.2 0.1 1.9 1 0 0 1 1 1 1 DnaJ domain BAF1_ABF1 PF04684.13 EDO17351.1 - 0.3 10.1 17.3 0.45 9.5 17.3 1.2 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor DEPP PF15343.6 EDO17351.1 - 1.1 9.4 9.3 2.5 8.1 9.3 1.6 1 0 0 1 1 1 0 Decidual protein induced by progesterone family Methyltrn_RNA_3 PF02598.17 EDO17352.1 - 1.3e-84 284.1 0.0 1.6e-84 283.8 0.0 1.0 1 0 0 1 1 1 1 Putative RNA methyltransferase MurJ PF03023.14 EDO17352.1 - 0.14 10.7 0.0 0.2 10.2 0.0 1.1 1 0 0 1 1 1 0 Lipid II flippase MurJ Glyco_hydro_17 PF00332.18 EDO17353.1 - 4.2e-94 315.6 1.4 5e-94 315.4 1.4 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 17 ABC_membrane PF00664.23 EDO17354.1 - 3.4e-81 272.9 38.5 4.9e-46 157.6 14.4 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EDO17354.1 - 1.7e-49 167.8 6.6 8.2e-31 107.3 0.2 3.5 3 1 0 3 3 2 2 ABC transporter SMC_N PF02463.19 EDO17354.1 - 7.4e-10 38.6 6.0 0.00021 20.8 0.9 4.5 1 1 2 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EDO17354.1 - 2.1e-08 33.8 1.4 0.00054 19.6 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_21 PF13304.6 EDO17354.1 - 2.4e-07 30.8 9.9 0.011 15.6 0.0 4.7 4 1 1 5 5 5 3 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 EDO17354.1 - 9.9e-06 25.6 1.3 0.039 13.9 0.4 2.7 2 0 0 2 2 2 2 RsgA GTPase AAA_18 PF13238.6 EDO17354.1 - 2.3e-05 25.0 2.8 0.2 12.2 0.0 3.5 3 0 0 3 3 2 2 AAA domain T2SSE PF00437.20 EDO17354.1 - 3.4e-05 23.0 0.0 0.011 14.8 0.0 2.4 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_30 PF13604.6 EDO17354.1 - 7.2e-05 22.6 1.0 0.16 11.7 0.1 3.1 3 0 0 3 3 3 2 AAA domain MMR_HSR1 PF01926.23 EDO17354.1 - 0.0001 22.4 1.1 0.12 12.4 0.1 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_16 PF13191.6 EDO17354.1 - 0.0001 22.7 0.3 0.11 12.9 0.1 2.7 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 EDO17354.1 - 0.00069 19.9 6.8 0.67 10.2 0.1 3.5 3 1 0 3 3 2 2 AAA domain AAA_7 PF12775.7 EDO17354.1 - 0.0012 18.4 0.6 1.2 8.6 0.1 2.5 2 0 0 2 2 2 2 P-loop containing dynein motor region cobW PF02492.19 EDO17354.1 - 0.0039 16.8 0.8 0.3 10.7 0.1 2.6 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain NTPase_1 PF03266.15 EDO17354.1 - 0.0043 17.0 1.1 1.6 8.6 0.2 2.8 2 0 0 2 2 2 1 NTPase AAA_27 PF13514.6 EDO17354.1 - 0.0088 15.7 0.6 0.37 10.3 0.1 2.5 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.12 EDO17354.1 - 0.0092 15.3 0.1 0.95 8.7 0.0 2.6 2 0 0 2 2 2 1 Zeta toxin IstB_IS21 PF01695.17 EDO17354.1 - 0.011 15.4 0.3 4.1 7.1 0.0 3.2 3 0 0 3 3 3 0 IstB-like ATP binding protein ATP_bind_1 PF03029.17 EDO17354.1 - 0.012 15.4 1.4 7.5 6.3 0.1 3.4 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein Sigma54_activat PF00158.26 EDO17354.1 - 0.012 15.3 0.2 4.5 6.9 0.0 2.9 3 0 0 3 3 3 0 Sigma-54 interaction domain Dynamin_N PF00350.23 EDO17354.1 - 0.013 15.5 4.5 13 5.8 0.0 4.0 4 0 0 4 4 4 0 Dynamin family ATP-synt_ab PF00006.25 EDO17354.1 - 0.013 15.1 0.0 2 8.0 0.0 2.3 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_28 PF13521.6 EDO17354.1 - 0.016 15.5 0.9 0.61 10.3 0.1 3.1 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.14 EDO17354.1 - 0.025 14.6 1.5 8.9 6.3 0.1 4.0 5 0 0 5 5 4 0 AAA domain (dynein-related subfamily) AAA PF00004.29 EDO17354.1 - 0.035 14.5 0.7 1.4 9.3 0.1 3.2 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) TsaE PF02367.17 EDO17354.1 - 0.048 13.7 0.3 2 8.4 0.1 2.6 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE TRAPP PF04051.16 EDO17354.1 - 0.056 13.2 0.1 0.12 12.1 0.1 1.5 1 0 0 1 1 1 0 Transport protein particle (TRAPP) component AAA_25 PF13481.6 EDO17354.1 - 0.13 11.9 0.1 7.3 6.1 0.0 2.6 3 0 0 3 3 2 0 AAA domain Mg_chelatase PF01078.21 EDO17354.1 - 0.14 11.6 1.4 9.1 5.6 0.2 2.4 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI APS_kinase PF01583.20 EDO17354.1 - 0.14 12.0 0.3 7.8 6.4 0.0 2.4 2 0 0 2 2 2 0 Adenylylsulphate kinase DUF87 PF01935.17 EDO17354.1 - 0.15 12.1 0.1 0.15 12.1 0.1 2.7 4 0 0 4 4 2 0 Helicase HerA, central domain RNA_helicase PF00910.22 EDO17354.1 - 0.16 12.4 2.5 23 5.4 0.0 3.6 4 0 0 4 4 2 0 RNA helicase PduV-EutP PF10662.9 EDO17354.1 - 0.18 11.5 3.4 4.1 7.2 0.1 3.4 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation MeaB PF03308.16 EDO17354.1 - 0.24 10.3 0.6 0.56 9.1 0.0 1.8 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_23 PF13476.6 EDO17354.1 - 0.48 10.9 33.0 0.12 12.9 0.4 4.7 4 1 0 4 4 3 0 AAA domain dNK PF01712.19 EDO17354.1 - 2.5 7.9 6.0 2.3 8.0 0.2 2.9 3 0 0 3 3 2 0 Deoxynucleoside kinase PRK PF00485.18 EDO17354.1 - 2.9 7.6 5.5 3.6 7.3 0.1 2.8 3 0 0 3 3 2 0 Phosphoribulokinase / Uridine kinase family AAA_11 PF13086.6 EDO17354.1 - 3.3 7.4 9.7 1.8 8.3 0.0 3.8 4 0 0 4 4 4 0 AAA domain AAA_19 PF13245.6 EDO17354.1 - 5.8 7.2 5.1 1.6 9.0 0.1 2.6 4 0 0 4 4 2 0 AAA domain Dus PF01207.17 EDO17355.1 - 3.1e-56 190.7 0.1 1.8e-55 188.2 0.0 2.1 1 1 1 2 2 2 2 Dihydrouridine synthase (Dus) PRK PF00485.18 EDO17356.1 - 1.1e-66 224.3 0.0 1.7e-66 223.7 0.0 1.3 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family UPRTase PF14681.6 EDO17356.1 - 7.1e-38 130.1 0.1 1e-37 129.6 0.1 1.2 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase AAA_18 PF13238.6 EDO17356.1 - 7.7e-05 23.2 0.0 0.00024 21.6 0.0 1.9 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 EDO17356.1 - 0.0027 17.0 0.0 0.0052 16.1 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin CPT PF07931.12 EDO17356.1 - 0.0029 17.5 0.0 0.0054 16.6 0.0 1.3 1 0 0 1 1 1 1 Chloramphenicol phosphotransferase-like protein AAA_17 PF13207.6 EDO17356.1 - 0.0065 16.9 0.0 4.1 7.8 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_33 PF13671.6 EDO17356.1 - 0.07 13.3 0.0 0.13 12.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain Cytidylate_kin PF02224.18 EDO17356.1 - 0.12 12.1 1.0 14 5.4 0.0 2.9 2 1 1 3 3 3 0 Cytidylate kinase OB_NTP_bind PF07717.16 EDO17357.1 - 6e-16 58.6 0.1 1.9e-15 57.0 0.1 1.9 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.23 EDO17357.1 - 7.9e-16 58.3 0.0 2e-15 57.0 0.0 1.7 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.31 EDO17357.1 - 1.6e-15 57.4 0.0 5.7e-15 55.6 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 EDO17357.1 - 1.5e-08 34.7 6.0 6.5e-08 32.5 0.2 3.5 3 0 0 3 3 3 1 DEAD/DEAH box helicase AAA_22 PF13401.6 EDO17357.1 - 5.4e-06 26.7 1.5 2.6e-05 24.5 0.1 2.5 2 0 0 2 2 2 1 AAA domain T2SSE PF00437.20 EDO17357.1 - 0.00045 19.4 0.1 0.0014 17.7 0.1 1.8 1 1 0 2 2 2 1 Type II/IV secretion system protein AAA_30 PF13604.6 EDO17357.1 - 0.00059 19.6 0.0 0.0015 18.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EDO17357.1 - 0.0012 19.2 3.2 0.0099 16.2 0.2 2.9 3 0 0 3 3 3 1 AAA domain Flavi_DEAD PF07652.14 EDO17357.1 - 0.0056 16.7 0.0 0.011 15.8 0.0 1.4 1 0 0 1 1 1 1 Flavivirus DEAD domain ABC_tran PF00005.27 EDO17357.1 - 0.023 15.2 0.6 0.19 12.3 0.0 2.7 2 0 0 2 2 2 0 ABC transporter PhoH PF02562.16 EDO17357.1 - 0.047 13.2 0.0 0.13 11.7 0.0 1.7 1 0 0 1 1 1 0 PhoH-like protein ATPase PF06745.13 EDO17357.1 - 0.26 10.6 2.4 0.24 10.7 0.1 2.1 2 1 0 2 2 2 0 KaiC ResIII PF04851.15 EDO17357.1 - 0.81 9.7 5.3 4.7 7.2 0.1 3.3 2 1 0 3 3 3 0 Type III restriction enzyme, res subunit AAA_14 PF13173.6 EDO17357.1 - 1.8 8.6 12.5 0.61 10.1 0.1 4.4 3 2 0 3 3 3 0 AAA domain Glyoxalase PF00903.25 EDO17358.1 - 3.7e-32 111.2 0.0 5.7e-19 68.6 0.0 2.2 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 EDO17358.1 - 5.3e-11 42.8 0.0 3.5e-06 27.3 0.0 3.4 2 2 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_6 PF18029.1 EDO17358.1 - 3.6e-06 27.7 0.0 0.0014 19.3 0.0 2.9 2 2 0 2 2 2 1 Glyoxalase-like domain Glyoxalase_2 PF12681.7 EDO17358.1 - 0.00022 21.1 0.3 4.2 7.3 0.0 4.0 4 0 0 4 4 4 2 Glyoxalase-like domain CppA_N PF14506.6 EDO17358.1 - 0.00042 20.4 0.1 0.13 12.3 0.0 2.4 2 0 0 2 2 2 2 CppA N-terminal Glyoxalase_3 PF13468.6 EDO17358.1 - 0.0008 19.6 0.0 0.17 12.0 0.0 2.9 2 2 0 2 2 2 1 Glyoxalase-like domain PFK PF00365.20 EDO17359.1 - 2.2e-175 581.7 1.4 4.9e-98 327.9 0.3 2.2 2 0 0 2 2 2 2 Phosphofructokinase UVR PF02151.19 EDO17359.1 - 0.16 11.8 0.1 0.48 10.3 0.1 1.8 1 0 0 1 1 1 0 UvrB/uvrC motif Porin_3 PF01459.22 EDO17360.1 - 1.6e-87 293.4 0.2 1.9e-87 293.2 0.2 1.0 1 0 0 1 1 1 1 Eukaryotic porin ERG2_Sigma1R PF04622.12 EDO17361.1 - 2.4e-91 304.7 0.8 2.8e-91 304.5 0.8 1.0 1 0 0 1 1 1 1 ERG2 and Sigma1 receptor like protein Autophagy_N PF03986.13 EDO17362.1 - 2.7e-41 140.7 0.9 4.7e-41 139.9 0.0 1.9 2 1 0 2 2 2 1 Autophagocytosis associated protein (Atg3), N-terminal domain Autophagy_C PF10381.9 EDO17362.1 - 1.1e-14 53.6 0.6 2.2e-14 52.7 0.6 1.6 1 0 0 1 1 1 1 Autophagocytosis associated protein C-terminal Autophagy_act_C PF03987.15 EDO17362.1 - 1.5e-13 51.1 0.0 3.1e-13 50.1 0.0 1.6 1 0 0 1 1 1 1 Autophagocytosis associated protein, active-site domain Cyclin_N PF00134.23 EDO17363.1 - 2e-34 118.1 0.0 4.4e-34 117.0 0.0 1.6 1 0 0 1 1 1 1 Cyclin, N-terminal domain Ribosomal_L36e PF01158.18 EDO17365.1 - 7e-36 122.4 3.8 7.8e-36 122.2 3.8 1.0 1 0 0 1 1 1 1 Ribosomal protein L36e HHH_2 PF12826.7 EDO17365.1 - 0.084 13.0 0.1 0.16 12.1 0.1 1.4 1 0 0 1 1 1 0 Helix-hairpin-helix motif Ribosomal_L28 PF00830.19 EDO17366.1 - 3e-19 69.0 2.0 3e-19 69.0 2.0 1.9 2 0 0 2 2 2 1 Ribosomal L28 family Helicase_Sgs1 PF11408.8 EDO17367.1 - 2.8e-37 126.6 0.1 7.1e-37 125.3 0.1 1.8 1 0 0 1 1 1 1 Sgs1 RecQ helicase RQC PF09382.10 EDO17367.1 - 5.1e-27 93.9 1.5 9.1e-27 93.1 0.3 2.1 2 0 0 2 2 2 1 RQC domain Helicase_C PF00271.31 EDO17367.1 - 2.8e-24 85.6 0.3 1e-17 64.5 0.0 3.5 2 0 0 2 2 2 2 Helicase conserved C-terminal domain DEAD PF00270.29 EDO17367.1 - 1.6e-22 80.1 0.1 1e-21 77.5 0.0 2.5 2 0 0 2 2 2 1 DEAD/DEAH box helicase RecQ_Zn_bind PF16124.5 EDO17367.1 - 7.6e-17 61.8 7.3 4.9e-16 59.2 7.3 2.6 1 0 0 1 1 1 1 RecQ zinc-binding ResIII PF04851.15 EDO17367.1 - 0.00016 21.7 0.0 0.00016 21.7 0.0 3.3 4 0 0 4 4 4 1 Type III restriction enzyme, res subunit AAA_34 PF13872.6 EDO17367.1 - 0.0062 15.5 0.1 0.063 12.1 0.1 2.2 2 0 0 2 2 2 1 P-loop containing NTP hydrolase pore-1 WD40 PF00400.32 EDO17368.1 - 4.3e-12 46.3 11.7 0.00011 22.9 0.2 5.0 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDO17368.1 - 0.0017 18.6 3.3 14 6.1 0.0 4.6 4 1 0 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Rhomboid PF01694.22 EDO17369.1 - 3.5e-18 66.0 15.0 3.5e-18 66.0 15.0 1.5 2 0 0 2 2 2 1 Rhomboid family DUF2975 PF11188.8 EDO17369.1 - 1.5 8.7 12.9 0.75 9.7 10.1 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF2975) DUF2075 PF09848.9 EDO17370.1 - 2.4e-112 375.8 0.0 3e-112 375.5 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_22 PF13401.6 EDO17370.1 - 1.1e-09 38.7 0.0 3.3e-09 37.1 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA PF00004.29 EDO17370.1 - 6.2e-05 23.4 0.0 0.00014 22.3 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 EDO17370.1 - 0.00026 20.7 0.0 0.0011 18.7 0.0 1.9 1 1 0 1 1 1 1 AAA domain TniB PF05621.11 EDO17370.1 - 0.0018 17.7 0.1 0.0062 16.0 0.1 1.9 1 1 0 1 1 1 1 Bacterial TniB protein ResIII PF04851.15 EDO17370.1 - 0.0019 18.2 0.1 1.3 9.0 0.0 2.4 1 1 1 2 2 2 2 Type III restriction enzyme, res subunit AAA_16 PF13191.6 EDO17370.1 - 0.0029 18.0 0.0 0.011 16.1 0.0 2.0 1 1 0 1 1 1 1 AAA ATPase domain AAA_14 PF13173.6 EDO17370.1 - 0.0029 17.6 0.3 0.0098 15.9 0.3 1.9 1 1 0 1 1 1 1 AAA domain DAP3 PF10236.9 EDO17370.1 - 0.0097 15.1 0.1 0.35 10.0 0.0 2.1 2 0 0 2 2 2 1 Mitochondrial ribosomal death-associated protein 3 T2SSE PF00437.20 EDO17370.1 - 0.014 14.5 0.0 0.021 13.9 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein PIF1 PF05970.14 EDO17370.1 - 0.016 14.4 0.1 0.099 11.8 0.0 2.2 2 1 0 2 2 2 0 PIF1-like helicase NTPase_1 PF03266.15 EDO17370.1 - 0.026 14.4 0.4 1.8 8.4 0.0 3.2 3 0 0 3 3 3 0 NTPase Zeta_toxin PF06414.12 EDO17370.1 - 0.059 12.7 0.0 0.13 11.6 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin FtsK_SpoIIIE PF01580.18 EDO17370.1 - 0.065 12.6 0.0 0.22 10.9 0.0 1.8 2 0 0 2 2 2 0 FtsK/SpoIIIE family Adeno_IVa2 PF02456.15 EDO17370.1 - 0.088 11.6 0.0 0.15 10.9 0.0 1.3 1 0 0 1 1 1 0 Adenovirus IVa2 protein AAA_18 PF13238.6 EDO17370.1 - 0.16 12.5 1.3 8.9 6.9 0.0 3.2 4 0 0 4 4 4 0 AAA domain ABC_tran PF00005.27 EDO17370.1 - 0.17 12.4 0.6 0.41 11.1 0.1 2.0 2 1 0 2 2 2 0 ABC transporter MMR_HSR1 PF01926.23 EDO17370.1 - 0.2 11.8 0.6 0.81 9.8 0.3 2.3 2 1 0 2 2 2 0 50S ribosome-binding GTPase UAA PF08449.11 EDO17371.1 - 2.4e-34 118.9 16.3 2.9e-34 118.7 16.3 1.1 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.20 EDO17371.1 - 6.6e-07 29.6 12.1 6.6e-07 29.6 12.1 2.9 3 1 0 3 3 3 2 EamA-like transporter family TPT PF03151.16 EDO17371.1 - 7.9e-07 28.7 11.6 0.0003 20.2 7.1 2.2 2 0 0 2 2 2 2 Triose-phosphate Transporter family DUF4500 PF14937.6 EDO17371.1 - 0.31 11.1 0.0 0.31 11.1 0.0 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4500) SRP68 PF16969.5 EDO17372.1 - 1.2e-62 212.8 14.4 1.9e-62 212.1 14.4 1.3 1 0 0 1 1 1 1 RNA-binding signal recognition particle 68 AF0941-like PF14591.6 EDO17372.1 - 0.00089 19.8 0.6 0.00089 19.8 0.6 3.3 3 0 0 3 3 3 1 AF0941-like RINGv PF12906.7 EDO17373.1 - 0.0012 18.9 7.1 0.0026 17.9 7.1 1.5 1 0 0 1 1 1 1 RING-variant domain zf-RING_2 PF13639.6 EDO17373.1 - 0.39 11.1 14.3 0.046 14.1 7.5 2.4 2 0 0 2 2 2 0 Ring finger domain FANCL_C PF11793.8 EDO17373.1 - 7.1 6.9 10.9 13 6.1 6.4 2.4 2 0 0 2 2 2 0 FANCL C-terminal domain RasGAP_C PF03836.15 EDO17374.1 - 5.5e-26 91.3 1.3 5.5e-26 91.3 1.3 2.9 3 0 0 3 3 3 1 RasGAP C-terminus IQ PF00612.27 EDO17374.1 - 3e-16 57.6 19.3 0.0035 17.0 0.9 10.1 10 0 0 10 10 10 5 IQ calmodulin-binding motif RasGAP PF00616.19 EDO17374.1 - 2.6e-15 56.7 4.0 2.6e-15 56.7 4.0 2.4 2 0 0 2 2 2 1 GTPase-activator protein for Ras-like GTPase CH PF00307.31 EDO17374.1 - 8.2e-11 42.1 0.3 3.7e-10 39.9 0.0 2.4 3 0 0 3 3 3 1 Calponin homology (CH) domain Glu-tRNAGln PF02686.15 EDO17374.1 - 0.068 13.5 4.4 7.6 6.9 0.3 3.8 3 0 0 3 3 3 0 Glu-tRNAGln amidotransferase C subunit DivIC PF04977.15 EDO17374.1 - 1 9.2 12.6 1.4 8.7 0.6 3.8 5 0 0 5 5 5 0 Septum formation initiator APC_N_CC PF16689.5 EDO17375.1 - 0.046 13.8 0.1 0.15 12.2 0.1 2.0 1 1 0 1 1 1 0 Coiled-coil N-terminus of APC, dimerisation domain Aida_N PF08910.10 EDO17375.1 - 0.072 13.5 0.7 0.13 12.7 0.7 1.5 1 0 0 1 1 1 0 Aida N-terminus CAP_C PF08603.11 EDO17375.1 - 1.6 8.3 9.3 11 5.7 0.6 3.1 2 1 1 3 3 3 0 Adenylate cyclase associated (CAP) C terminal TIP49 PF06068.13 EDO17376.1 - 1.5e-156 521.0 2.1 2e-156 520.6 2.1 1.1 1 0 0 1 1 1 1 TIP49 P-loop domain TIP49_C PF17856.1 EDO17376.1 - 2.6e-22 78.7 1.1 9.1e-22 77.0 0.9 2.1 2 0 0 2 2 2 1 TIP49 AAA-lid domain AAA PF00004.29 EDO17376.1 - 1.5e-08 35.2 0.6 7.2e-05 23.2 0.1 2.8 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 EDO17376.1 - 9.6e-08 31.9 0.5 0.0012 18.6 0.0 2.7 3 0 0 3 3 3 2 Holliday junction DNA helicase RuvB P-loop domain DnaB_C PF03796.15 EDO17376.1 - 2.6e-05 23.7 0.2 6.4e-05 22.4 0.2 1.6 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain AAA_16 PF13191.6 EDO17376.1 - 0.00013 22.4 0.2 0.00054 20.4 0.2 2.0 1 1 0 1 1 1 1 AAA ATPase domain AAA_19 PF13245.6 EDO17376.1 - 0.00071 19.9 0.2 0.0042 17.4 0.2 2.2 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EDO17376.1 - 0.00098 19.4 0.1 0.13 12.5 0.0 2.4 1 1 1 2 2 2 1 AAA domain Mg_chelatase PF01078.21 EDO17376.1 - 0.0047 16.3 1.6 0.074 12.4 0.2 2.5 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 EDO17376.1 - 0.0058 16.6 0.1 0.92 9.5 0.0 2.7 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_25 PF13481.6 EDO17376.1 - 0.0088 15.6 0.1 0.02 14.5 0.1 1.5 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EDO17376.1 - 0.012 16.1 0.1 0.047 14.2 0.0 2.1 3 0 0 3 3 2 0 AAA domain AAA_28 PF13521.6 EDO17376.1 - 0.015 15.6 0.0 0.042 14.1 0.0 1.8 1 0 0 1 1 1 0 AAA domain TFX_C PF14601.6 EDO17376.1 - 0.023 14.6 0.1 0.067 13.2 0.1 1.8 1 0 0 1 1 1 0 DNA_binding protein, TFX, C-term Sigma54_activat PF00158.26 EDO17376.1 - 0.055 13.2 0.2 9.1 5.9 0.0 2.8 3 0 0 3 3 3 0 Sigma-54 interaction domain AAA_33 PF13671.6 EDO17376.1 - 0.1 12.7 0.0 0.28 11.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 EDO17376.1 - 0.23 10.9 1.2 0.57 9.7 0.0 2.1 3 0 0 3 3 3 0 P-loop containing dynein motor region ATP-synt_C PF00137.21 EDO17377.1 - 1.1e-30 105.8 32.5 1.6e-16 60.4 9.1 2.1 2 0 0 2 2 2 2 ATP synthase subunit C Mis14 PF08641.12 EDO17378.1 - 1.7e-16 60.7 4.1 2e-16 60.5 2.5 1.9 2 0 0 2 2 2 1 Kinetochore protein Mis14 like BLOC1_2 PF10046.9 EDO17378.1 - 0.22 11.9 3.2 1.4 9.2 1.3 2.7 2 1 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF4407 PF14362.6 EDO17378.1 - 0.24 10.7 5.6 0.25 10.6 4.9 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) TPR_MLP1_2 PF07926.12 EDO17378.1 - 0.39 10.8 6.6 0.82 9.7 0.1 2.7 2 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein FTA4 PF13093.6 EDO17378.1 - 2.4 8.0 8.3 9.7 6.0 8.3 2.1 1 1 0 1 1 1 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 zf-H2C2_2 PF13465.6 EDO17379.1 - 1.9e-08 34.4 2.0 1.9e-08 34.4 2.0 3.0 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2 PF00096.26 EDO17379.1 - 6.9e-08 32.5 13.4 4.8e-05 23.6 1.2 3.0 3 0 0 3 3 3 2 Zinc finger, C2H2 type Mucin PF01456.17 EDO17379.1 - 0.0025 17.8 12.1 0.0025 17.8 12.1 2.1 2 1 0 2 2 2 1 Mucin-like glycoprotein zf-C2H2_8 PF15909.5 EDO17379.1 - 0.0052 17.1 2.7 0.0052 17.1 2.7 1.8 2 0 0 2 2 2 1 C2H2-type zinc ribbon zf-C2H2_4 PF13894.6 EDO17379.1 - 0.019 15.8 12.9 0.076 13.9 2.3 2.8 3 0 0 3 3 3 0 C2H2-type zinc finger zf-MYST PF17772.1 EDO17379.1 - 0.027 14.1 0.4 0.027 14.1 0.4 2.0 2 1 0 2 2 2 0 MYST family zinc finger domain zf-met PF12874.7 EDO17379.1 - 0.064 13.7 0.7 0.064 13.7 0.7 2.5 2 1 0 2 2 2 0 Zinc-finger of C2H2 type MutS_IV PF05190.18 EDO17379.1 - 0.11 12.9 1.0 0.2 12.1 1.0 1.4 1 0 0 1 1 1 0 MutS family domain IV zf-C2H2_3rep PF18868.1 EDO17379.1 - 0.48 11.1 8.2 0.69 10.6 7.1 1.8 1 1 0 1 1 1 0 Zinc finger C2H2-type, 3 repeats zf-C2H2_6 PF13912.6 EDO17379.1 - 2.1 8.4 7.0 0.15 12.1 1.5 1.9 2 0 0 2 2 2 0 C2H2-type zinc finger Mito_carr PF00153.27 EDO17381.1 - 1.4e-49 166.0 5.8 2.9e-18 65.6 0.2 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Biotin_lipoyl PF00364.22 EDO17382.1 - 4.8e-20 71.2 0.6 9.8e-20 70.2 0.6 1.6 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.17 EDO17382.1 - 0.00062 20.0 0.2 0.0016 18.8 0.2 1.7 1 0 0 1 1 1 1 e3 binding domain Biotin_lipoyl_2 PF13533.6 EDO17382.1 - 0.048 13.5 1.7 1.3 8.9 0.0 3.0 2 1 1 3 3 3 0 Biotin-lipoyl like ATP-sulfurylase PF01747.17 EDO17383.1 - 2.2e-86 288.8 0.0 3e-86 288.3 0.0 1.1 1 0 0 1 1 1 1 ATP-sulfurylase PUA_2 PF14306.6 EDO17383.1 - 2e-47 160.8 0.0 3.1e-47 160.2 0.0 1.3 1 0 0 1 1 1 1 PUA-like domain Cytotoxic PF09000.10 EDO17383.1 - 0.055 13.8 0.0 0.12 12.7 0.0 1.5 1 0 0 1 1 1 0 Cytotoxic Gp_dh_C PF02800.20 EDO17384.1 - 1.4e-72 242.5 0.1 2.1e-72 241.9 0.1 1.3 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.24 EDO17384.1 - 4.1e-40 136.2 0.2 1e-39 135.0 0.2 1.7 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain DapB_N PF01113.20 EDO17384.1 - 0.0027 17.8 0.1 0.0088 16.2 0.1 2.0 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus OsmC PF02566.19 EDO17384.1 - 0.12 12.9 0.0 1.4 9.5 0.0 2.3 2 0 0 2 2 2 0 OsmC-like protein Memo PF01875.17 EDO17385.1 - 4.6e-86 288.3 0.0 6.3e-86 287.9 0.0 1.2 1 0 0 1 1 1 1 Memo-like protein Glyco_hydro_16 PF00722.21 EDO17386.1 - 8.8e-47 158.9 0.2 8.8e-47 158.9 0.2 2.1 2 1 0 2 2 2 1 Glycosyl hydrolases family 16 SOG2 PF10428.9 EDO17386.1 - 2.3 7.3 25.5 3.1 6.9 25.5 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein FAM196 PF15265.6 EDO17386.1 - 9.9 5.5 14.9 14 5.1 14.9 1.1 1 0 0 1 1 1 0 FAM196 family RNA_pol_Rpb4 PF03874.16 EDO17387.1 - 3e-35 121.2 9.0 3.6e-35 121.0 9.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb4 DUF4100 PF13352.6 EDO17387.1 - 0.026 14.3 4.0 0.037 13.8 4.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4100) Branch PF02485.21 EDO17387.1 - 0.029 13.9 0.6 0.038 13.5 0.6 1.2 1 0 0 1 1 1 0 Core-2/I-Branching enzyme VraX PF17412.2 EDO17387.1 - 0.14 11.8 2.9 17 5.2 0.1 3.3 3 0 0 3 3 3 0 Family of unknown function VTC PF09359.10 EDO17388.1 - 3e-99 331.9 0.1 5.1e-99 331.1 0.1 1.4 1 0 0 1 1 1 1 VTC domain SPX PF03105.19 EDO17388.1 - 9.5e-11 42.2 13.9 1.7e-05 24.9 2.0 3.8 3 1 1 4 4 4 3 SPX domain DUF202 PF02656.15 EDO17388.1 - 2.3e-09 37.6 5.3 4.8e-09 36.5 5.3 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF202) LXG PF04740.12 EDO17388.1 - 0.082 12.6 1.5 5.1 6.7 0.1 2.4 1 1 0 2 2 2 0 LXG domain of WXG superfamily Bax1-I PF01027.20 EDO17388.1 - 0.2 11.5 5.5 0.31 10.8 5.5 1.2 1 0 0 1 1 1 0 Inhibitor of apoptosis-promoting Bax1 Cpn60_TCP1 PF00118.24 EDO17389.1 - 2.4e-162 541.0 5.1 2.7e-162 540.8 5.1 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Sad1_UNC PF07738.13 EDO17390.1 - 2.4e-08 34.0 0.3 5.1e-06 26.5 0.3 2.7 1 1 0 1 1 1 1 Sad1 / UNC-like C-terminal Baculo_PEP_C PF04513.12 EDO17390.1 - 0.0063 16.6 1.9 0.0063 16.6 1.9 2.8 2 1 0 2 2 2 1 Baculovirus polyhedron envelope protein, PEP, C terminus SDA1 PF05285.12 EDO17390.1 - 2.4 7.5 13.3 3.7 6.9 13.3 1.3 1 0 0 1 1 1 0 SDA1 IZUMO PF15005.6 EDO17390.1 - 6.8 7.2 6.9 45 4.5 0.0 3.5 3 0 0 3 3 3 0 Izumo sperm-egg fusion, Ig domain-associated Bot1p PF12298.8 EDO17391.1 - 5.9e-64 215.4 0.2 7.9e-64 215.0 0.2 1.1 1 0 0 1 1 1 1 Eukaryotic mitochondrial regulator protein SH3_2 PF07653.17 EDO17392.1 - 6.5e-09 35.3 0.0 1.8e-08 33.9 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EDO17392.1 - 1.2e-07 31.2 0.3 1.2e-07 31.2 0.3 2.1 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 EDO17392.1 - 2.3e-06 27.4 1.3 4.7e-06 26.3 0.2 2.1 2 0 0 2 2 2 1 Variant SH3 domain PseudoU_synth_2 PF00849.22 EDO17393.1 - 3e-27 95.6 0.0 4.7e-27 95.0 0.0 1.3 1 0 0 1 1 1 1 RNA pseudouridylate synthase LUC7 PF03194.15 EDO17393.1 - 0.084 12.5 0.1 0.15 11.7 0.1 1.3 1 0 0 1 1 1 0 LUC7 N_terminus TFA2_Winged_2 PF18121.1 EDO17395.1 - 2.1e-21 75.4 1.2 3.9e-21 74.5 0.1 2.1 2 0 0 2 2 2 1 TFA2 Winged helix domain 2 TFIIE_beta PF02186.15 EDO17395.1 - 8.6e-17 61.2 0.5 2.2e-16 59.9 0.5 1.8 1 0 0 1 1 1 1 TFIIE beta subunit core domain PgdA_N PF18627.1 EDO17395.1 - 0.0022 17.7 1.2 0.0046 16.6 1.0 1.5 1 1 0 1 1 1 1 Peptidoglycan GlcNAc deacetylase N-terminal domain CRAL_TRIO PF00650.20 EDO17396.1 - 1.1e-27 96.7 0.4 2.2e-27 95.7 0.1 1.6 2 0 0 2 2 2 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 EDO17396.1 - 0.00023 21.3 0.3 0.00057 20.0 0.3 1.7 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain INTS5_N PF14837.6 EDO17396.1 - 0.021 14.4 0.1 0.27 10.8 0.0 2.0 2 0 0 2 2 2 0 Integrator complex subunit 5 N-terminus B_solenoid_dext PF18841.1 EDO17396.1 - 0.086 13.2 0.1 0.29 11.5 0.1 1.9 1 0 0 1 1 1 0 Beta solenoid repeat from Dextranase Pkinase PF00069.25 EDO17397.1 - 8.2e-49 166.3 0.3 4.5e-48 163.9 0.3 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO17397.1 - 2.8e-20 72.7 0.0 5e-20 71.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EDO17397.1 - 0.049 13.5 0.0 0.1 12.5 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family RNA_pol_Rpb4 PF03874.16 EDO17398.1 - 3.7e-35 120.9 13.4 5.7e-34 117.1 13.4 2.2 1 1 0 1 1 1 1 RNA polymerase Rpb4 DUF913 PF06025.12 EDO17398.1 - 0.018 14.0 3.3 0.025 13.6 3.3 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Rtf2 PF04641.12 EDO17398.1 - 0.7 9.2 9.7 0.99 8.7 9.7 1.2 1 0 0 1 1 1 0 Rtf2 RING-finger SLC12 PF03522.15 EDO17398.1 - 0.94 8.4 10.5 1.2 8.1 10.5 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Glyco_transf_15 PF01793.16 EDO17399.1 - 6.1e-102 341.2 16.6 7.2e-102 341.0 16.6 1.1 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase Holin_BhlA PF10960.8 EDO17399.1 - 0.078 13.0 0.4 0.18 11.8 0.4 1.5 1 0 0 1 1 1 0 BhlA holin family Ribosomal_L1 PF00687.21 EDO17400.1 - 1.3e-42 145.8 3.9 1.6e-42 145.6 3.9 1.0 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family RNA_pol_Rpb1_6 PF04992.14 EDO17400.1 - 0.07 12.9 0.1 0.2 11.4 0.1 1.8 1 1 0 1 1 1 0 RNA polymerase Rpb1, domain 6 DEAD PF00270.29 EDO17401.1 - 1.3e-43 148.8 2.0 1.6e-43 148.5 0.4 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDO17401.1 - 5.8e-31 107.1 0.2 1.7e-30 105.7 0.1 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDO17401.1 - 1.2e-08 35.2 0.0 2.5e-08 34.1 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 EDO17401.1 - 0.0014 19.0 0.1 0.014 15.8 0.1 2.1 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 EDO17401.1 - 0.0026 17.5 0.1 0.004 16.9 0.1 1.3 1 0 0 1 1 1 1 AAA domain UTP25 PF06862.12 EDO17401.1 - 0.0047 15.8 0.2 1.8 7.2 0.0 2.3 2 0 0 2 2 2 2 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 CMS1 PF14617.6 EDO17401.1 - 0.069 12.5 0.0 0.16 11.2 0.0 1.6 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit Ribosomal_S21e PF01249.18 EDO17402.1 - 1e-38 131.3 0.1 1.1e-38 131.2 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S21e VCH_CASS14 PF18315.1 EDO17402.1 - 0.067 13.2 0.0 0.18 11.9 0.0 1.6 1 1 1 2 2 2 0 Integron cassette protein VCH_CASS1 chain Ras PF00071.22 EDO17403.1 - 7.5e-27 93.9 0.0 1.6e-26 92.8 0.0 1.5 2 0 0 2 2 2 1 Ras family Roc PF08477.13 EDO17403.1 - 6.2e-17 61.9 0.0 1.2e-16 61.0 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 EDO17403.1 - 0.008 16.2 0.0 0.019 15.1 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase Arf PF00025.21 EDO17403.1 - 0.016 14.7 0.0 0.035 13.6 0.0 1.6 1 0 0 1 1 1 0 ADP-ribosylation factor family DNA_pol3_a_NI PF14480.6 EDO17403.1 - 0.017 15.1 0.6 0.048 13.6 0.6 1.8 1 0 0 1 1 1 0 DNA polymerase III polC-type N-terminus I ATPase_2 PF01637.18 EDO17403.1 - 0.021 14.7 1.2 0.039 13.8 0.0 1.9 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea PAP2 PF01569.21 EDO17404.1 - 9.9e-18 64.2 4.2 9.9e-18 64.2 4.2 1.9 1 1 1 2 2 2 1 PAP2 superfamily PAP2_3 PF14378.6 EDO17404.1 - 0.039 13.6 7.0 0.1 12.2 7.0 1.8 1 1 0 1 1 1 0 PAP2 superfamily NAD_Gly3P_dh_N PF01210.23 EDO17406.1 - 3.5e-52 176.5 0.1 5.4e-52 175.9 0.1 1.3 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_Gly3P_dh_C PF07479.14 EDO17406.1 - 2.1e-40 138.3 0.1 3.5e-40 137.6 0.1 1.3 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus F420_oxidored PF03807.17 EDO17406.1 - 0.017 15.7 0.0 11 6.7 0.0 2.4 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent Arginosuc_synth PF00764.19 EDO17407.1 - 6.7e-164 545.8 0.0 7.7e-164 545.6 0.0 1.0 1 0 0 1 1 1 1 Arginosuccinate synthase QueC PF06508.13 EDO17407.1 - 3.1e-05 23.6 0.0 6e-05 22.6 0.0 1.4 1 0 0 1 1 1 1 Queuosine biosynthesis protein QueC tRNA_Me_trans PF03054.16 EDO17407.1 - 0.00038 19.3 0.0 0.00059 18.7 0.0 1.3 1 0 0 1 1 1 1 tRNA methyl transferase Asn_synthase PF00733.21 EDO17407.1 - 0.044 13.4 0.0 0.061 13.0 0.0 1.2 1 0 0 1 1 1 0 Asparagine synthase zf-C2H2_4 PF13894.6 EDO17408.1 - 0.0065 17.2 5.4 2.9 9.0 0.0 3.3 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2 PF00096.26 EDO17408.1 - 0.018 15.5 13.5 0.063 13.8 0.2 3.5 3 1 0 3 3 3 0 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EDO17408.1 - 0.044 14.2 1.5 2.5 8.7 0.1 2.6 2 0 0 2 2 2 0 Zinc-finger double domain zf-C2H2_6 PF13912.6 EDO17408.1 - 0.27 11.3 4.4 20 5.3 0.2 3.3 3 0 0 3 3 3 0 C2H2-type zinc finger Oxysterol_BP PF01237.18 EDO17409.1 - 5.6e-129 430.2 0.3 9.1e-129 429.5 0.3 1.3 1 0 0 1 1 1 1 Oxysterol-binding protein Ank_5 PF13857.6 EDO17409.1 - 7.4e-11 42.1 0.5 0.00021 21.5 0.1 3.2 3 0 0 3 3 3 2 Ankyrin repeats (many copies) PH PF00169.29 EDO17409.1 - 2.7e-10 40.7 0.1 7.5e-10 39.3 0.1 1.8 1 0 0 1 1 1 1 PH domain Ank_4 PF13637.6 EDO17409.1 - 4e-10 40.0 0.0 0.00018 22.0 0.0 3.0 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EDO17409.1 - 4.4e-09 35.8 0.0 0.0059 17.0 0.0 3.5 3 0 0 3 3 3 2 Ankyrin repeat Ank_2 PF12796.7 EDO17409.1 - 1.2e-08 35.5 0.0 0.0022 18.6 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) PH_8 PF15409.6 EDO17409.1 - 1.3e-07 31.8 0.1 3.1e-07 30.6 0.1 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain Ank PF00023.30 EDO17409.1 - 4.8e-07 29.9 0.0 0.0024 18.3 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeat PH_11 PF15413.6 EDO17409.1 - 0.0064 16.9 3.7 0.0081 16.6 0.6 2.8 2 1 0 2 2 2 1 Pleckstrin homology domain Pkinase PF00069.25 EDO17410.1 - 3.2e-77 259.5 0.1 7.4e-77 258.3 0.1 1.7 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO17410.1 - 9.4e-55 185.7 0.0 1.7e-54 184.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDO17410.1 - 4.2e-05 23.0 0.4 0.0027 17.1 0.0 2.6 3 0 0 3 3 3 1 Kinase-like Pkinase_fungal PF17667.1 EDO17410.1 - 0.0054 15.6 0.0 0.015 14.1 0.0 1.7 2 0 0 2 2 2 1 Fungal protein kinase BLOC1_2 PF10046.9 EDO17410.1 - 0.13 12.5 1.1 29 5.1 0.1 2.9 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Pkinase PF00069.25 EDO17411.1 - 2.6e-53 181.1 0.5 1.6e-52 178.5 0.5 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO17411.1 - 1.7e-32 112.8 0.0 7.2e-32 110.7 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EDO17411.1 - 0.0023 16.8 0.0 0.0051 15.6 0.0 1.5 2 0 0 2 2 2 1 Fungal protein kinase SAICAR_synt PF01259.18 EDO17412.1 - 6.4e-102 340.5 0.2 7.9e-102 340.2 0.2 1.1 1 0 0 1 1 1 1 SAICAR synthetase UPF0086 PF01868.16 EDO17412.1 - 0.0011 18.9 0.1 0.14 12.1 0.0 2.5 2 0 0 2 2 2 2 Domain of unknown function UPF0086 EMP24_GP25L PF01105.24 EDO17413.1 - 1.3e-27 96.9 4.4 1.3e-27 96.9 4.4 1.9 2 0 0 2 2 2 1 emp24/gp25L/p24 family/GOLD ATP-synt_8 PF00895.20 EDO17413.1 - 1.8 9.1 5.4 0.87 10.1 0.7 2.4 2 0 0 2 2 2 0 ATP synthase protein 8 RNA_pol_I_TF PF04090.12 EDO17415.1 - 2e-69 233.1 5.7 3.9e-69 232.1 5.7 1.5 1 0 0 1 1 1 1 RNA polymerase I specific initiation factor Spt5_N PF11942.8 EDO17415.1 - 0.045 14.7 6.0 0.045 14.7 6.0 2.1 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal HsdM_N PF12161.8 EDO17415.1 - 0.3 11.7 0.0 0.3 11.7 0.0 2.9 2 2 0 2 2 2 0 HsdM N-terminal domain BLOC1S3 PF15753.5 EDO17415.1 - 2.3 8.3 7.9 0.35 11.0 3.4 1.8 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex 1 subunit 3 RPA43_OB PF17875.1 EDO17415.1 - 5.6 7.6 8.8 11 6.7 8.8 1.4 1 0 0 1 1 1 0 RPA43 OB domain in RNA Pol I PLA2_B PF01735.18 EDO17416.1 - 2.5e-225 748.5 5.4 3.1e-225 748.2 5.4 1.1 1 0 0 1 1 1 1 Lysophospholipase catalytic domain TAF4 PF05236.14 EDO17417.1 - 1.4e-58 198.8 3.2 1.4e-58 198.8 3.2 2.7 2 1 0 2 2 2 1 Transcription initiation factor TFIID component TAF4 family RTC PF01137.21 EDO17418.1 - 1.1e-44 152.3 0.0 1.3e-44 152.1 0.0 1.0 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase RTC_insert PF05189.13 EDO17418.1 - 6.1e-32 110.2 0.0 9.3e-32 109.6 0.0 1.3 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase (RTC), insert domain PX PF00787.24 EDO17419.1 - 2.7e-21 75.7 0.6 1.1e-20 73.8 0.6 2.0 1 0 0 1 1 1 1 PX domain CRAL_TRIO_N PF03765.15 EDO17419.1 - 0.07 13.3 0.0 0.2 11.9 0.0 1.8 1 0 0 1 1 1 0 CRAL/TRIO, N-terminal domain CREPT PF16566.5 EDO17419.1 - 0.1 12.8 0.3 0.5 10.5 0.1 2.1 2 0 0 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour DHR10 PF18595.1 EDO17419.1 - 0.15 12.1 0.0 5.8 7.0 0.0 2.5 2 0 0 2 2 2 0 Designed helical repeat protein 10 domain DUF4618 PF15397.6 EDO17419.1 - 0.41 10.0 5.3 4.9 6.5 0.0 3.4 2 1 2 4 4 4 0 Domain of unknown function (DUF4618) Polyketide_cyc PF03364.20 EDO17420.1 - 1.1e-17 64.4 0.0 1.5e-17 64.0 0.0 1.1 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport DUF2228 PF10228.9 EDO17420.1 - 0.054 13.2 0.1 0.071 12.8 0.1 1.1 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2228) DUF2076 PF09849.9 EDO17421.1 - 5.6e-07 29.9 13.3 6.7e-07 29.6 13.3 1.2 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2076) CHCH PF06747.13 EDO17421.1 - 2.7e-05 24.2 4.4 4.4e-05 23.5 4.4 1.4 1 0 0 1 1 1 1 CHCH domain RskA PF10099.9 EDO17421.1 - 0.0011 19.3 2.4 0.0014 19.0 2.4 1.1 1 0 0 1 1 1 1 Anti-sigma-K factor rskA RSF PF14876.6 EDO17421.1 - 0.077 12.0 5.5 0.57 9.1 0.8 2.1 1 1 1 2 2 2 0 Respiratory growth transcriptional regulator MSA-2c PF12238.8 EDO17421.1 - 0.78 9.7 7.3 1.4 8.8 7.3 1.5 1 0 0 1 1 1 0 Merozoite surface antigen 2c LapA_dom PF06305.11 EDO17422.1 - 0.0018 18.1 0.3 0.0027 17.5 0.3 1.3 1 0 0 1 1 1 1 Lipopolysaccharide assembly protein A domain Topoisom_I PF01028.20 EDO17423.1 - 4.1e-98 327.3 1.2 4.1e-98 327.3 1.2 2.3 2 1 1 3 3 3 1 Eukaryotic DNA topoisomerase I, catalytic core Topoisom_I_N PF02919.15 EDO17423.1 - 2.1e-93 311.7 0.6 2.1e-93 311.7 0.6 3.0 3 1 0 3 3 3 1 Eukaryotic DNA topoisomerase I, DNA binding fragment Topo_C_assoc PF14370.6 EDO17423.1 - 3.9e-33 113.2 0.4 1.3e-32 111.6 0.4 2.0 1 0 0 1 1 1 1 C-terminal topoisomerase domain Pkinase PF00069.25 EDO17424.1 - 4.5e-76 255.7 0.0 6.9e-76 255.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO17424.1 - 8.5e-41 139.9 0.0 1.3e-40 139.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase POLO_box PF00659.18 EDO17424.1 - 3.8e-26 91.1 0.0 2.1e-13 50.3 0.0 2.8 2 0 0 2 2 2 2 POLO box duplicated region Kinase-like PF14531.6 EDO17424.1 - 3.8e-08 33.0 0.0 3.1e-06 26.7 0.0 2.2 2 0 0 2 2 2 2 Kinase-like SH3_3 PF08239.11 EDO17424.1 - 0.0019 18.5 0.1 0.0041 17.4 0.1 1.5 1 0 0 1 1 1 1 Bacterial SH3 domain Kdo PF06293.14 EDO17424.1 - 0.0099 15.2 0.0 0.025 14.0 0.0 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 EDO17424.1 - 0.035 13.0 0.8 0.1 11.5 0.1 1.8 1 1 0 1 1 1 0 Haspin like kinase domain RNA_pol_L_2 PF13656.6 EDO17425.1 - 4.5e-26 90.4 0.1 7e-26 89.8 0.1 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.24 EDO17425.1 - 1.2e-09 37.5 0.0 2.2e-09 36.6 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Thymidylate_kin PF02223.17 EDO17425.1 - 0.086 12.5 0.0 0.11 12.2 0.0 1.1 1 0 0 1 1 1 0 Thymidylate kinase Sin3a_C PF16879.5 EDO17426.1 - 1.2e-77 261.4 3.8 1.2e-77 261.4 3.8 3.9 4 0 0 4 4 4 1 C-terminal domain of Sin3a protein PAH PF02671.21 EDO17426.1 - 1.7e-45 152.9 12.5 1.5e-17 63.5 2.0 4.2 3 0 0 3 3 3 3 Paired amphipathic helix repeat Sin3_corepress PF08295.12 EDO17426.1 - 3.4e-43 145.7 1.8 4.9e-43 145.2 0.2 2.3 2 0 0 2 2 2 1 Sin3 family co-repressor DHHC PF01529.20 EDO17427.1 - 1.8e-32 112.2 12.7 1.8e-32 112.2 12.7 2.0 2 0 0 2 2 2 1 DHHC palmitoyltransferase Ribo_biogen_C PF04034.13 EDO17428.1 - 3.1e-51 172.4 0.0 4.9e-51 171.7 0.0 1.3 1 0 0 1 1 1 1 Ribosome biogenesis protein, C-terminal RLI PF04068.15 EDO17428.1 - 2.9e-15 55.8 0.2 5.8e-15 54.8 0.2 1.6 1 0 0 1 1 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI VPS9 PF02204.18 EDO17429.1 - 2e-12 47.3 1.5 3.7e-12 46.4 0.3 2.2 2 0 0 2 2 2 1 Vacuolar sorting protein 9 (VPS9) domain Ank_5 PF13857.6 EDO17429.1 - 0.016 15.5 0.1 1.1 9.7 0.0 3.4 3 0 0 3 3 3 0 Ankyrin repeats (many copies) SGTA_dimer PF16546.5 EDO17430.1 - 1.8e-24 85.3 1.2 1.8e-24 85.3 1.2 1.9 2 0 0 2 2 2 1 Homodimerisation domain of SGTA TPR_1 PF00515.28 EDO17430.1 - 9.8e-18 63.2 8.6 7.8e-08 31.8 0.3 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 EDO17430.1 - 5.8e-16 57.2 9.5 0.00012 21.9 0.2 4.4 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.6 EDO17430.1 - 1.2e-11 44.1 10.7 2.1e-05 24.1 0.5 3.5 1 1 2 3 3 3 3 TPR repeat TPR_17 PF13431.6 EDO17430.1 - 2e-07 30.9 1.0 0.003 17.8 0.2 3.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 EDO17430.1 - 1.4e-06 28.5 4.4 0.057 13.7 0.0 3.3 2 2 1 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 EDO17430.1 - 1.9e-06 27.6 15.6 0.00048 20.1 0.3 4.5 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 EDO17430.1 - 2e-06 28.3 2.5 0.01 16.4 0.5 2.8 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 EDO17430.1 - 1.2e-05 25.7 0.4 1.3 10.0 0.0 3.7 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 EDO17430.1 - 6.5e-05 23.4 3.4 0.013 15.9 0.3 3.2 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 EDO17430.1 - 0.00044 20.0 5.0 0.19 11.6 0.2 3.5 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_6 PF13174.6 EDO17430.1 - 0.00052 20.5 6.0 0.24 12.1 0.1 4.0 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 EDO17430.1 - 0.0025 17.7 4.7 19 5.6 0.1 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat BTAD PF03704.17 EDO17430.1 - 0.0078 16.6 2.9 0.0096 16.4 0.3 2.4 2 1 0 2 2 2 1 Bacterial transcriptional activator domain HRDC PF00570.23 EDO17430.1 - 0.044 13.8 0.3 0.33 11.0 0.1 2.2 2 0 0 2 2 2 0 HRDC domain STI1 PF17830.1 EDO17430.1 - 0.12 12.4 15.0 7.6 6.6 12.0 2.9 1 1 1 2 2 2 0 STI1 domain ANAPC3 PF12895.7 EDO17430.1 - 0.14 12.4 3.3 1.4 9.2 2.8 2.5 1 1 1 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 PEP-utilisers_N PF05524.13 EDO17430.1 - 0.14 12.3 4.8 2.5 8.3 4.9 3.1 2 1 0 2 2 2 0 PEP-utilising enzyme, N-terminal GerD PF17898.1 EDO17430.1 - 0.15 12.1 6.9 1.1 9.2 6.2 2.5 1 1 0 1 1 1 0 Spore germination GerD central core domain Fis1_TPR_C PF14853.6 EDO17430.1 - 0.25 11.4 1.0 40 4.4 0.1 3.0 2 0 0 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat MIT PF04212.18 EDO17430.1 - 8.6 6.5 14.5 3.8 7.7 0.3 4.1 2 2 1 3 3 3 0 MIT (microtubule interacting and transport) domain Alg6_Alg8 PF03155.15 EDO17431.1 - 5.9e-146 487.2 26.8 7.4e-146 486.9 26.8 1.0 1 0 0 1 1 1 1 ALG6, ALG8 glycosyltransferase family Ras PF00071.22 EDO17432.1 - 3.1e-57 192.7 0.5 3.7e-57 192.5 0.5 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EDO17432.1 - 2.7e-34 118.0 0.1 4.2e-34 117.3 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EDO17432.1 - 2.1e-15 56.6 0.1 2.5e-15 56.4 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EDO17432.1 - 1.6e-08 34.2 0.2 1.8e-08 34.0 0.2 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EDO17432.1 - 3.7e-07 29.9 0.4 2.4e-05 24.0 0.4 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EDO17432.1 - 9.5e-07 28.9 0.1 3.8e-06 26.9 0.0 1.8 1 1 1 2 2 2 1 50S ribosome-binding GTPase SRPRB PF09439.10 EDO17432.1 - 2.7e-06 27.0 0.2 3.7e-06 26.5 0.2 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit RsgA_GTPase PF03193.16 EDO17432.1 - 0.00012 22.0 0.3 0.041 13.8 0.0 2.4 1 1 2 3 3 3 1 RsgA GTPase ATP_bind_1 PF03029.17 EDO17432.1 - 0.00015 21.6 0.6 0.0038 17.0 0.1 2.1 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein AAA_22 PF13401.6 EDO17432.1 - 0.0029 17.9 0.0 0.0064 16.8 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EDO17432.1 - 0.0057 17.1 0.5 0.016 15.6 0.5 1.9 1 1 0 1 1 1 1 AAA ATPase domain PduV-EutP PF10662.9 EDO17432.1 - 0.017 14.9 0.2 0.15 11.8 0.0 2.2 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation TniB PF05621.11 EDO17432.1 - 0.023 14.1 0.0 0.038 13.4 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein cobW PF02492.19 EDO17432.1 - 0.024 14.3 0.1 0.1 12.2 0.0 1.9 1 1 1 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain NACHT PF05729.12 EDO17432.1 - 0.026 14.4 0.0 0.049 13.5 0.0 1.5 1 0 0 1 1 1 0 NACHT domain AAA_7 PF12775.7 EDO17432.1 - 0.029 13.9 0.1 0.044 13.3 0.1 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region NTPase_1 PF03266.15 EDO17432.1 - 0.032 14.2 0.1 0.14 12.1 0.0 1.9 2 0 0 2 2 2 0 NTPase Septin PF00735.18 EDO17432.1 - 0.033 13.5 0.2 0.16 11.3 0.0 1.9 2 0 0 2 2 2 0 Septin AAA_33 PF13671.6 EDO17432.1 - 0.044 13.9 0.0 0.096 12.8 0.0 1.6 1 1 1 2 2 2 0 AAA domain AAA_24 PF13479.6 EDO17432.1 - 0.045 13.5 0.2 0.14 11.8 0.0 1.9 2 1 0 2 2 2 0 AAA domain ATPase_2 PF01637.18 EDO17432.1 - 0.11 12.4 0.4 0.67 9.8 0.0 2.0 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea DNA_pol_A_exo1 PF01612.20 EDO17433.1 - 7.6e-48 162.5 1.6 1.4e-47 161.7 0.7 2.0 2 0 0 2 2 2 1 3'-5' exonuclease PMC2NT PF08066.12 EDO17433.1 - 3.7e-22 78.8 2.2 3.7e-22 78.8 2.2 2.8 3 1 1 4 4 4 1 PMC2NT (NUC016) domain HRDC PF00570.23 EDO17433.1 - 8.9e-12 44.8 0.0 2.3e-11 43.5 0.0 1.7 1 0 0 1 1 1 1 HRDC domain VPS13 PF16908.5 EDO17433.1 - 0.067 13.0 2.7 0.076 12.8 0.7 2.1 2 0 0 2 2 2 0 Vacuolar sorting-associated protein 13, N-terminal Cyclin PF08613.11 EDO17434.1 - 7e-36 124.0 2.1 7e-36 124.0 2.1 2.2 2 2 0 2 2 2 1 Cyclin Cyclin_N PF00134.23 EDO17434.1 - 1.8e-05 24.5 0.0 0.00038 20.2 0.1 2.3 2 0 0 2 2 2 1 Cyclin, N-terminal domain RT_RNaseH PF17917.1 EDO17436.1 - 2.1e-13 50.5 0.0 3.6e-13 49.7 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 EDO17436.1 - 2.2e-12 46.9 0.0 3.7e-12 46.1 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_2 PF07727.14 EDO17438.1 - 7.8e-32 110.8 0.4 2.1e-31 109.4 0.3 1.7 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 EDO17438.1 - 5.4e-20 71.8 0.1 2.7e-18 66.3 0.0 2.4 2 0 0 2 2 2 1 Integrase core domain gag_pre-integrs PF13976.6 EDO17438.1 - 9.6e-05 22.2 0.1 0.00027 20.8 0.1 1.8 1 0 0 1 1 1 1 GAG-pre-integrase domain rve_3 PF13683.6 EDO17438.1 - 0.032 14.0 0.0 0.15 11.9 0.0 2.2 2 0 0 2 2 2 0 Integrase core domain Cpn60_TCP1 PF00118.24 EDO17439.1 - 3.9e-85 286.3 8.4 1.1e-84 284.8 8.4 1.6 1 1 0 1 1 1 1 TCP-1/cpn60 chaperonin family DAGK_cat PF00781.24 EDO17440.1 - 5.3e-25 87.5 0.0 8.1e-25 86.9 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain Menin PF05053.13 EDO17440.1 - 0.0033 15.9 12.2 0.0045 15.4 12.2 1.1 1 0 0 1 1 1 1 Menin GREB1 PF15782.5 EDO17440.1 - 0.06 10.5 4.5 0.078 10.1 4.5 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DUF2457 PF10446.9 EDO17440.1 - 0.065 12.4 3.3 0.096 11.8 3.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Lin-8 PF03353.15 EDO17440.1 - 0.088 12.4 9.0 0.14 11.6 9.0 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist PAP1 PF08601.10 EDO17440.1 - 0.1 12.3 17.6 0.15 11.7 17.6 1.2 1 0 0 1 1 1 0 Transcription factor PAP1 ALMT PF11744.8 EDO17440.1 - 0.26 10.1 4.7 0.37 9.6 4.7 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Gti1_Pac2 PF09729.9 EDO17440.1 - 0.3 11.2 8.0 0.52 10.4 8.0 1.3 1 0 0 1 1 1 0 Gti1/Pac2 family Macoilin PF09726.9 EDO17440.1 - 0.62 8.6 12.7 0.78 8.2 12.7 1.1 1 0 0 1 1 1 0 Macoilin family CSG2 PF16965.5 EDO17440.1 - 0.75 8.7 3.8 1.1 8.1 3.8 1.2 1 0 0 1 1 1 0 Ceramide synthase regulator EPL1 PF10513.9 EDO17440.1 - 2.4 8.5 15.9 5.3 7.4 15.9 1.5 1 0 0 1 1 1 0 Enhancer of polycomb-like SR-25 PF10500.9 EDO17440.1 - 6.2 6.4 17.6 11 5.5 17.6 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein tRNA-synt_1c PF00749.21 EDO17441.1 - 1.5e-112 375.5 0.0 2.6e-112 374.8 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA_synt_1c_R1 PF04558.15 EDO17441.1 - 1.3e-51 174.8 0.8 2.2e-51 174.1 0.8 1.4 1 0 0 1 1 1 1 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1 tRNA-synt_1c_C PF03950.18 EDO17441.1 - 1.4e-35 122.7 0.1 4.1e-34 118.0 0.0 2.4 1 1 1 2 2 2 1 tRNA synthetases class I (E and Q), anti-codon binding domain tRNA_synt_1c_R2 PF04557.15 EDO17441.1 - 2.4e-15 57.2 3.6 2.4e-15 57.2 3.6 1.8 2 0 0 2 2 2 1 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 TetR_N PF00440.23 EDO17441.1 - 0.069 13.0 0.0 3.5 7.5 0.0 2.6 2 0 0 2 2 2 0 Bacterial regulatory proteins, tetR family Red1 PF07964.11 EDO17442.1 - 4.8e-253 841.8 67.0 5.5e-253 841.6 67.0 1.0 1 0 0 1 1 1 1 Rec10 / Red1 Ribosomal_S28e PF01200.18 EDO17443.1 - 4.4e-32 109.9 2.4 4.8e-32 109.7 2.4 1.0 1 0 0 1 1 1 1 Ribosomal protein S28e PIN_4 PF13638.6 EDO17444.1 - 2.1e-33 115.4 0.1 3.8e-33 114.6 0.1 1.5 1 0 0 1 1 1 1 PIN domain PIN_9 PF18477.1 EDO17444.1 - 0.0012 19.2 0.1 0.59 10.5 0.0 2.6 2 1 1 3 3 3 2 PIN like domain PIN_12 PF16289.5 EDO17444.1 - 0.1 13.1 6.3 0.32 11.5 0.0 3.8 2 2 2 4 4 4 0 PIN domain RHD3 PF05879.12 EDO17445.1 - 5.4e-236 785.3 24.2 6.9e-236 785.0 24.2 1.1 1 0 0 1 1 1 1 Root hair defective 3 GTP-binding protein (RHD3) MMR_HSR1 PF01926.23 EDO17445.1 - 0.00041 20.4 0.0 0.0012 18.9 0.0 1.9 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 EDO17445.1 - 0.00085 19.4 0.0 0.00085 19.4 0.0 2.5 3 0 0 3 3 3 1 Dynamin family ABC_tran PF00005.27 EDO17445.1 - 0.12 12.9 0.1 0.47 11.0 0.0 2.1 2 0 0 2 2 2 0 ABC transporter DUF410 PF04190.13 EDO17446.1 - 1.7e-83 280.3 1.1 2.1e-83 280.0 1.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF410) NUDIX PF00293.28 EDO17447.1 - 2.6e-16 59.9 0.2 3.3e-16 59.5 0.2 1.2 1 0 0 1 1 1 1 NUDIX domain GalP_UDP_transf PF01087.22 EDO17448.1 - 1e-68 231.4 0.3 3.2e-68 229.8 0.2 1.7 2 0 0 2 2 2 1 Galactose-1-phosphate uridyl transferase, N-terminal domain GalP_UDP_tr_C PF02744.17 EDO17448.1 - 2.2e-66 222.7 0.7 3.5e-66 222.0 0.1 1.6 2 0 0 2 2 2 1 Galactose-1-phosphate uridyl transferase, C-terminal domain DUF3721 PF12518.8 EDO17448.1 - 0.37 10.7 1.6 0.89 9.5 1.6 1.6 1 0 0 1 1 1 0 Protein of unknown function GalKase_gal_bdg PF10509.9 EDO17449.1 - 2.7e-21 74.9 0.0 5.4e-21 73.9 0.0 1.5 1 0 0 1 1 1 1 Galactokinase galactose-binding signature GHMP_kinases_N PF00288.26 EDO17449.1 - 2.5e-16 59.7 0.3 5.1e-16 58.7 0.3 1.6 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 EDO17449.1 - 1e-12 48.3 0.0 2.2e-12 47.2 0.0 1.5 1 0 0 1 1 1 1 GHMP kinases C terminal HTH_23 PF13384.6 EDO17449.1 - 0.025 14.4 0.1 0.11 12.3 0.0 2.0 2 0 0 2 2 2 0 Homeodomain-like domain LicD PF04991.13 EDO17449.1 - 0.074 13.2 0.0 0.15 12.2 0.0 1.5 1 0 0 1 1 1 0 LicD family Sigma70_r4 PF04545.16 EDO17449.1 - 0.12 12.0 0.0 0.28 10.7 0.0 1.6 1 0 0 1 1 1 0 Sigma-70, region 4 DUF1748 PF08520.10 EDO17449.1 - 0.13 12.2 0.0 0.34 10.8 0.0 1.7 1 0 0 1 1 1 0 Fungal protein of unknown function (DUF1748) Sigma70_ECF PF07638.11 EDO17449.1 - 0.16 11.8 0.0 0.37 10.7 0.0 1.5 1 0 0 1 1 1 0 ECF sigma factor HTH_11 PF08279.12 EDO17449.1 - 0.17 11.8 0.0 0.59 10.1 0.0 1.9 2 0 0 2 2 2 0 HTH domain ABC2_membrane PF01061.24 EDO17450.1 - 1.1e-59 201.5 65.9 4.4e-34 117.8 20.6 3.1 3 0 0 3 3 3 2 ABC-2 type transporter ABC_tran PF00005.27 EDO17450.1 - 4.6e-38 130.8 0.3 1.7e-17 64.2 0.0 3.1 3 0 0 3 3 3 2 ABC transporter PDR_CDR PF06422.12 EDO17450.1 - 9.1e-33 112.0 8.3 2.7e-27 94.5 0.0 3.6 3 0 0 3 3 3 2 CDR ABC transporter RsgA_GTPase PF03193.16 EDO17450.1 - 4.6e-07 29.9 1.1 0.00012 22.0 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase AAA_16 PF13191.6 EDO17450.1 - 5.5e-05 23.6 1.0 0.011 16.1 0.0 2.8 2 1 0 2 2 2 1 AAA ATPase domain AAA_29 PF13555.6 EDO17450.1 - 0.00016 21.3 0.3 0.2 11.4 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_22 PF13401.6 EDO17450.1 - 0.00019 21.7 0.6 0.01 16.1 0.1 2.8 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 EDO17450.1 - 0.00043 20.3 0.4 0.24 11.5 0.0 2.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase SMC_N PF02463.19 EDO17450.1 - 0.00074 19.0 0.0 0.5 9.8 0.0 3.2 3 0 0 3 3 3 1 RecF/RecN/SMC N terminal domain cobW PF02492.19 EDO17450.1 - 0.00084 19.0 2.1 0.0039 16.8 0.1 2.2 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_21 PF13304.6 EDO17450.1 - 0.0012 18.7 0.5 1.1 9.0 0.0 2.5 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system Septin PF00735.18 EDO17450.1 - 0.015 14.6 0.2 0.077 12.3 0.1 2.1 2 0 0 2 2 2 0 Septin AAA_33 PF13671.6 EDO17450.1 - 0.016 15.4 0.6 0.14 12.3 0.0 2.4 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 EDO17450.1 - 0.025 14.5 1.3 0.36 10.7 0.2 2.5 2 0 0 2 2 2 0 NACHT domain AAA_30 PF13604.6 EDO17450.1 - 0.027 14.2 0.6 2.4 7.8 0.1 2.3 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 EDO17450.1 - 0.033 14.7 0.2 1.5 9.4 0.0 2.5 2 0 0 2 2 2 0 AAA domain NTPase_1 PF03266.15 EDO17450.1 - 0.059 13.3 0.8 22 4.9 0.0 3.1 3 0 0 3 3 3 0 NTPase FtsK_SpoIIIE PF01580.18 EDO17450.1 - 0.06 12.7 1.4 17 4.6 0.1 3.2 3 0 0 3 3 3 0 FtsK/SpoIIIE family AAA_23 PF13476.6 EDO17450.1 - 0.075 13.5 0.4 0.39 11.2 0.1 2.3 2 0 0 2 2 1 0 AAA domain AAA_24 PF13479.6 EDO17450.1 - 0.076 12.7 0.7 0.67 9.7 0.1 2.5 3 0 0 3 3 3 0 AAA domain AAA_25 PF13481.6 EDO17450.1 - 0.081 12.5 0.6 0.15 11.7 0.1 1.6 2 0 0 2 2 1 0 AAA domain RNA_helicase PF00910.22 EDO17450.1 - 0.091 13.2 0.1 7.8 6.9 0.0 2.9 2 0 0 2 2 2 0 RNA helicase ABC_ATPase PF09818.9 EDO17450.1 - 0.14 10.9 0.2 0.24 10.1 0.2 1.3 1 0 0 1 1 1 0 Predicted ATPase of the ABC class T2SSE PF00437.20 EDO17450.1 - 0.15 11.1 1.5 1.6 7.7 0.1 2.2 2 0 0 2 2 2 0 Type II/IV secretion system protein TsaE PF02367.17 EDO17450.1 - 0.15 12.0 0.6 0.42 10.6 0.1 1.9 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE NB-ARC PF00931.22 EDO17450.1 - 0.2 10.8 0.3 14 4.8 0.0 2.4 2 0 0 2 2 2 0 NB-ARC domain AAA_28 PF13521.6 EDO17450.1 - 0.21 11.8 1.2 0.44 10.8 0.2 2.0 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.6 EDO17450.1 - 0.35 11.2 1.0 28 5.0 0.0 2.7 3 0 0 3 3 3 0 AAA domain Zeta_toxin PF06414.12 EDO17450.1 - 0.72 9.1 1.9 7.7 5.7 0.0 2.5 3 0 0 3 3 3 0 Zeta toxin Macro PF01661.21 EDO17451.1 - 3.6e-26 91.5 0.0 8e-26 90.4 0.0 1.5 1 1 0 1 1 1 1 Macro domain Chitin_synth_2 PF03142.15 EDO17452.1 - 4.1e-285 946.4 0.2 4.1e-285 946.4 0.2 1.8 2 0 0 2 2 2 1 Chitin synthase Glyco_tranf_2_3 PF13641.6 EDO17452.1 - 9.7e-12 45.3 0.0 5.5e-10 39.5 0.0 2.9 2 1 1 3 3 3 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.6 EDO17452.1 - 3.7e-10 40.1 9.4 2.6e-09 37.3 9.4 2.4 1 1 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_transf_21 PF13506.6 EDO17452.1 - 0.0018 17.8 0.0 0.0061 16.0 0.0 1.8 2 0 0 2 2 2 1 Glycosyl transferase family 21 Glycos_transf_2 PF00535.26 EDO17452.1 - 0.012 15.4 0.0 0.14 11.9 0.0 2.3 2 0 0 2 2 2 0 Glycosyl transferase family 2 Cyt-b5 PF00173.28 EDO17452.1 - 0.13 12.4 0.0 7.8 6.7 0.0 2.7 2 1 0 2 2 2 0 Cytochrome b5-like Heme/Steroid binding domain SCO1-SenC PF02630.14 EDO17453.1 - 4.8e-45 152.8 0.0 1.3e-44 151.4 0.0 1.7 2 0 0 2 2 2 1 SCO1/SenC CSG2 PF16965.5 EDO17454.1 - 5.9e-160 532.6 22.2 2.9e-139 464.5 13.4 2.0 1 1 1 2 2 2 2 Ceramide synthase regulator Pkinase PF00069.25 EDO17455.1 - 1.1e-62 211.8 0.3 8.2e-61 205.7 0.2 2.4 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO17455.1 - 1.5e-32 112.9 0.0 2.7e-31 108.8 0.0 2.3 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDO17455.1 - 0.00027 20.4 0.1 0.0083 15.5 0.0 2.3 2 1 0 2 2 2 1 Kinase-like Pkinase_C PF00433.24 EDO17455.1 - 0.00042 21.0 0.1 0.0011 19.6 0.1 1.8 1 0 0 1 1 1 1 Protein kinase C terminal domain CTP_transf_1 PF01148.20 EDO17456.1 - 7.3e-79 265.3 19.8 9.7e-79 264.9 19.8 1.2 1 0 0 1 1 1 1 Cytidylyltransferase family Methyltransf_25 PF13649.6 EDO17457.1 - 1.5e-11 44.8 0.0 4.2e-11 43.4 0.0 1.8 2 0 0 2 2 1 1 Methyltransferase domain PrmA PF06325.13 EDO17457.1 - 3.1e-11 43.2 0.0 5e-11 42.5 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_31 PF13847.6 EDO17457.1 - 6.2e-10 39.1 0.0 1.1e-09 38.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EDO17457.1 - 1.2e-08 35.4 0.0 2.9e-08 34.2 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EDO17457.1 - 1.4e-07 31.5 0.0 1.7e-07 31.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_9 PF08003.11 EDO17457.1 - 1e-06 27.9 0.1 1.5e-06 27.4 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) CMAS PF02353.20 EDO17457.1 - 1.4e-05 24.5 0.0 2e-05 24.0 0.0 1.3 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase MTS PF05175.14 EDO17457.1 - 5.6e-05 22.8 0.0 9.6e-05 22.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_18 PF12847.7 EDO17457.1 - 7.4e-05 22.7 0.0 0.00013 22.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EDO17457.1 - 0.00011 22.8 0.0 0.00025 21.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.19 EDO17457.1 - 0.0014 18.8 0.0 0.0045 17.1 0.0 1.8 2 0 0 2 2 2 1 FtsJ-like methyltransferase Methyltransf_16 PF10294.9 EDO17457.1 - 0.0023 17.7 0.0 0.0038 17.0 0.0 1.3 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_2 PF00891.18 EDO17457.1 - 0.004 16.5 0.0 0.0065 15.8 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_32 PF13679.6 EDO17457.1 - 0.0063 16.5 0.0 0.014 15.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 EDO17457.1 - 0.011 15.5 0.0 0.017 14.9 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Ubie_methyltran PF01209.18 EDO17457.1 - 0.013 14.8 0.2 0.025 13.9 0.2 1.5 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family PRMT5 PF05185.16 EDO17457.1 - 0.024 14.5 0.0 0.047 13.5 0.0 1.5 1 0 0 1 1 1 0 PRMT5 arginine-N-methyltransferase Methyltransf_4 PF02390.17 EDO17457.1 - 0.093 12.2 0.7 0.17 11.4 0.0 1.7 2 0 0 2 2 2 0 Putative methyltransferase DOT1 PF08123.13 EDO17457.1 - 0.099 12.2 0.0 0.16 11.4 0.0 1.4 1 0 0 1 1 1 0 Histone methylation protein DOT1 Cons_hypoth95 PF03602.15 EDO17457.1 - 0.15 11.7 0.0 0.25 11.0 0.0 1.3 1 0 0 1 1 1 0 Conserved hypothetical protein 95 DASH_Dad1 PF08649.10 EDO17458.1 - 1.8e-23 82.5 0.2 2.6e-23 81.9 0.2 1.3 1 0 0 1 1 1 1 DASH complex subunit Dad1 IPK PF03770.16 EDO17459.1 - 3.6e-47 160.8 1.1 5.1e-47 160.3 0.0 1.9 2 0 0 2 2 2 1 Inositol polyphosphate kinase Fig1 PF12351.8 EDO17460.1 - 6.1e-60 202.4 5.2 6.1e-60 202.4 5.2 1.9 2 0 0 2 2 2 1 Ca2+ regulator and membrane fusion protein Fig1 DUF749 PF05370.11 EDO17460.1 - 0.075 13.1 0.0 0.18 11.9 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF749) ASFV_J13L PF05568.11 EDO17460.1 - 0.88 9.3 4.0 6.1 6.6 0.0 2.3 2 0 0 2 2 2 0 African swine fever virus J13L protein Viral_Beta_CD PF04530.12 EDO17460.1 - 1.8 8.8 5.4 1.4 9.3 0.8 2.6 3 0 0 3 3 3 0 Viral Beta C/D like family Endomucin PF07010.12 EDO17460.1 - 1.9 8.4 8.6 2.9 7.8 4.6 2.2 2 0 0 2 2 2 0 Endomucin DUF3328 PF11807.8 EDO17460.1 - 9.8 5.9 9.1 10 5.8 0.1 3.1 2 1 0 3 3 3 0 Domain of unknown function (DUF3328) Acyltransferase PF01553.21 EDO17461.1 - 7.3e-30 103.3 0.0 1.2e-29 102.6 0.0 1.4 1 0 0 1 1 1 1 Acyltransferase Acyltransf_C PF16076.5 EDO17461.1 - 3.6e-16 59.0 0.3 7.6e-16 58.0 0.3 1.5 1 0 0 1 1 1 1 Acyltransferase C-terminus Voltage_CLC PF00654.20 EDO17461.1 - 0.12 11.6 0.8 0.18 11.0 0.8 1.2 1 0 0 1 1 1 0 Voltage gated chloride channel BP28CT PF08146.12 EDO17462.1 - 0.12 12.3 0.6 8.3 6.2 0.0 2.8 3 0 0 3 3 3 0 BP28CT (NUC211) domain tRNA-synt_2b PF00587.25 EDO17463.1 - 5.4e-34 117.7 0.1 9.5e-34 116.9 0.1 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.22 EDO17463.1 - 3.8e-23 81.8 10.5 3.8e-23 81.8 10.5 1.7 2 0 0 2 2 2 1 Seryl-tRNA synthetase N-terminal domain GCR1_C PF12550.8 EDO17463.1 - 1 9.7 4.8 1.4 9.3 1.4 2.5 2 0 0 2 2 2 0 Transcriptional activator of glycolytic enzymes DJ-1_PfpI PF01965.24 EDO17465.1 - 3.4e-08 33.5 0.0 1.7e-07 31.2 0.0 2.0 1 1 0 1 1 1 1 DJ-1/PfpI family ThiJ_like PF17124.5 EDO17465.1 - 0.0011 18.8 0.2 0.0093 15.7 0.1 2.0 2 0 0 2 2 2 1 ThiJ/PfpI family-like Latrotoxin_C PF15658.6 EDO17465.1 - 0.12 12.2 0.0 2.2 8.0 0.0 2.1 2 0 0 2 2 2 0 Latrotoxin C-terminal domain Homeodomain PF00046.29 EDO17466.1 - 3.2e-14 52.5 0.9 5.3e-14 51.8 0.9 1.4 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EDO17466.1 - 1.1e-06 28.5 0.2 2.2e-06 27.4 0.1 1.6 2 0 0 2 2 2 1 Homeobox KN domain Homez PF11569.8 EDO17466.1 - 0.0021 17.5 0.0 0.0041 16.6 0.0 1.4 1 0 0 1 1 1 1 Homeodomain leucine-zipper encoding, Homez DUF5100 PF17029.5 EDO17466.1 - 0.039 13.8 0.1 0.048 13.5 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5100) GLEYA PF10528.9 EDO17467.1 - 1.3e-21 76.8 0.6 1.2e-20 73.8 0.6 3.0 1 0 0 1 1 1 1 GLEYA domain Plasmodium_HRP PF05403.11 EDO17467.1 - 4.3e-12 46.3 0.0 1 9.1 0.0 7.3 7 0 0 7 7 7 5 Plasmodium histidine-rich protein (HRPII/III) Flocculin PF00624.18 EDO17469.1 - 1.5e-10 41.1 22.1 1.5e-10 41.1 22.1 12.0 9 3 0 10 10 10 1 Flocculin repeat AWS PF17907.1 EDO17469.1 - 7.3 6.7 19.6 74 3.5 0.3 5.2 5 0 0 5 5 5 0 AWS domain Rdx PF10262.9 EDO17470.1 - 8.9e-27 93.1 0.0 1.2e-26 92.7 0.0 1.2 1 0 0 1 1 1 1 Rdx family USP8_dimer PF08969.11 EDO17471.1 - 9.3e-06 25.8 1.8 1.7e-05 25.0 1.3 1.7 1 1 0 1 1 1 1 USP8 dimerisation domain VASt PF16016.5 EDO17472.1 - 1.9e-35 122.5 0.8 4.9e-35 121.2 0.8 1.7 1 0 0 1 1 1 1 VAD1 Analog of StAR-related lipid transfer domain GRAM PF02893.20 EDO17472.1 - 2.5e-26 91.8 0.1 9.3e-26 90.0 0.0 2.0 2 0 0 2 2 2 1 GRAM domain Lzipper-MIP1 PF14389.6 EDO17472.1 - 0.026 14.8 0.9 0.27 11.6 1.2 2.2 2 0 0 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 Syntaxin_2 PF14523.6 EDO17472.1 - 0.058 13.8 0.3 0.43 11.0 0.2 2.4 2 0 0 2 2 2 0 Syntaxin-like protein Med14 PF08638.11 EDO17473.1 - 8.1e-58 195.0 0.6 1.7e-57 194.0 0.6 1.6 1 0 0 1 1 1 1 Mediator complex subunit MED14 ADH_N PF08240.12 EDO17474.1 - 3.6e-27 94.4 6.2 5e-27 93.9 0.2 3.0 3 0 0 3 3 3 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EDO17474.1 - 1.3e-25 89.9 0.0 2.7e-25 88.8 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 EDO17474.1 - 1.7e-08 34.2 0.2 2.7e-08 33.5 0.2 1.3 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus ADH_zinc_N_2 PF13602.6 EDO17474.1 - 0.00051 21.1 0.0 0.0012 19.9 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase UDPG_MGDP_dh_N PF03721.14 EDO17474.1 - 0.01 15.4 0.1 0.016 14.8 0.1 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain AlaDh_PNT_C PF01262.21 EDO17474.1 - 0.05 12.9 0.7 0.099 11.9 0.7 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain 2-Hacid_dh_C PF02826.19 EDO17474.1 - 0.13 11.6 0.1 0.24 10.7 0.1 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Cu-oxidase_2 PF07731.14 EDO17475.1 - 3.1e-44 150.0 7.5 3.4e-41 140.2 0.8 2.9 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase_3 PF07732.15 EDO17475.1 - 1.4e-35 121.8 3.0 8.4e-32 109.7 0.1 3.5 4 0 0 4 4 4 2 Multicopper oxidase Cu-oxidase PF00394.22 EDO17475.1 - 2.7e-35 121.8 0.5 1.6e-32 112.8 0.0 3.6 4 0 0 4 4 4 1 Multicopper oxidase Cupredoxin_1 PF13473.6 EDO17475.1 - 0.0016 18.5 0.0 1.5 8.9 0.0 3.7 3 1 1 4 4 4 1 Cupredoxin-like domain rRNA_processing PF08524.11 EDO17476.1 - 3.5e-40 137.4 26.8 4e-40 137.3 26.8 1.0 1 0 0 1 1 1 1 rRNA processing PPR_2 PF13041.6 EDO17477.1 - 4.7e-14 52.3 11.9 0.00031 20.9 0.0 9.1 6 2 5 11 11 11 3 PPR repeat family PPR_long PF17177.4 EDO17477.1 - 5.5e-11 42.2 0.6 7.6e-07 28.7 0.0 3.2 3 1 0 4 4 4 2 Pentacotripeptide-repeat region of PRORP PPR PF01535.20 EDO17477.1 - 4.5e-10 39.1 11.5 2.4 8.6 0.1 9.5 10 0 0 10 10 10 3 PPR repeat PPR_3 PF13812.6 EDO17477.1 - 2.8e-06 27.3 5.2 1.7 8.8 0.1 5.2 4 1 0 4 4 4 3 Pentatricopeptide repeat domain PPR_1 PF12854.7 EDO17477.1 - 0.089 12.5 1.3 9.6 6.0 0.0 4.2 4 0 0 4 4 4 0 PPR repeat RIH_assoc PF08454.11 EDO17477.1 - 8.3 6.3 7.4 4.2 7.3 0.2 3.9 3 2 0 3 3 3 0 RyR and IP3R Homology associated Actin PF00022.19 EDO17478.1 - 5.2e-151 502.9 0.0 1.5e-150 501.4 0.0 1.6 1 1 0 1 1 1 1 Actin Ntox50 PF15542.6 EDO17479.1 - 0.14 13.0 0.4 8.2 7.3 0.0 2.4 2 0 0 2 2 2 0 Bacterial toxin 50 Methyltransf_34 PF11312.8 EDO17480.1 - 4.9e-92 308.4 0.7 6.3e-92 308.1 0.7 1.1 1 0 0 1 1 1 1 Putative SAM-dependent methyltransferase LuxS PF02664.15 EDO17480.1 - 0.1 12.3 0.0 0.27 10.9 0.0 1.7 1 0 0 1 1 1 0 S-Ribosylhomocysteinase (LuxS) DUF726 PF05277.12 EDO17481.1 - 4.7e-97 325.0 3.3 7.3e-97 324.4 3.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF726) OppC_N PF12911.7 EDO17481.1 - 0.18 11.8 0.0 1.9 8.5 0.0 2.3 2 0 0 2 2 2 0 N-terminal TM domain of oligopeptide transport permease C EMC3_TMCO1 PF01956.16 EDO17481.1 - 2.8 7.6 5.5 0.9 9.3 0.3 2.5 2 1 1 3 3 3 0 Integral membrane protein EMC3/TMCO1-like bZIP_2 PF07716.15 EDO17482.1 - 4.3e-06 26.7 9.5 9.3e-06 25.6 9.5 1.5 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.21 EDO17482.1 - 0.00015 21.8 12.0 0.00015 21.8 12.0 1.7 2 0 0 2 2 2 1 bZIP transcription factor SHMT PF00464.19 EDO17483.1 - 1.3e-207 689.2 0.0 1.4e-207 689.0 0.0 1.0 1 0 0 1 1 1 1 Serine hydroxymethyltransferase Aminotran_1_2 PF00155.21 EDO17483.1 - 4.4e-06 26.1 0.0 8.3e-06 25.2 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 EDO17483.1 - 0.0014 17.6 0.0 0.002 17.1 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 EDO17483.1 - 0.0059 15.9 0.0 0.0089 15.3 0.0 1.4 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.17 EDO17483.1 - 0.16 11.2 0.0 0.29 10.4 0.0 1.3 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family FA_hydroxylase PF04116.13 EDO17484.1 - 4.6e-22 78.8 18.1 4.6e-22 78.8 18.1 2.3 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily STE2 PF02116.15 EDO17485.1 - 2.1e-86 289.7 18.5 2.5e-86 289.5 18.5 1.0 1 0 0 1 1 1 1 Fungal pheromone mating factor STE2 GPCR OSTMP1 PF09777.9 EDO17485.1 - 0.093 12.1 0.8 0.27 10.6 0.0 2.0 1 1 1 2 2 2 0 Osteopetrosis-associated transmembrane protein 1 precursor PGAP1 PF07819.13 EDO17486.1 - 2.7e-96 321.7 0.0 4.3e-96 321.1 0.0 1.3 1 0 0 1 1 1 1 PGAP1-like protein Abhydrolase_5 PF12695.7 EDO17486.1 - 0.0092 15.8 0.0 0.017 14.9 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Palm_thioest PF02089.15 EDO17486.1 - 0.011 15.6 0.0 0.018 14.9 0.0 1.3 1 0 0 1 1 1 0 Palmitoyl protein thioesterase Abhydrolase_6 PF12697.7 EDO17486.1 - 0.017 15.7 0.0 0.029 15.0 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family DUF2974 PF11187.8 EDO17486.1 - 0.05 13.2 0.0 0.18 11.3 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2974) Lipase_3 PF01764.25 EDO17486.1 - 0.057 13.3 0.0 0.11 12.3 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) Abhydrolase_1 PF00561.20 EDO17486.1 - 0.13 11.9 0.0 0.35 10.5 0.0 1.6 1 0 0 1 1 1 0 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EDO17486.1 - 0.14 11.4 0.0 0.23 10.7 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Abhydrolase_3 PF07859.13 EDO17486.1 - 0.16 11.8 0.0 0.29 10.9 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold DUF3835 PF12927.7 EDO17487.1 - 6.9e-17 62.1 0.2 6.9e-17 62.1 0.2 7.3 6 2 1 7 7 7 2 Domain of unknown function (DUF3835) Prefoldin PF02996.17 EDO17487.1 - 6.7e-09 35.7 0.0 6.7e-09 35.7 0.0 3.4 3 0 0 3 3 3 1 Prefoldin subunit NADH-u_ox-rdase PF10785.9 EDO17488.1 - 0.11 13.2 0.0 0.24 12.1 0.0 1.5 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase complex I, 21 kDa subunit ApbA_C PF08546.11 EDO17488.1 - 0.15 12.3 0.0 3.6 7.8 0.0 2.7 3 0 0 3 3 3 0 Ketopantoate reductase PanE/ApbA C terminal GATA PF00320.27 EDO17490.1 - 1.6e-17 62.8 2.3 3.1e-17 61.9 2.3 1.5 1 0 0 1 1 1 1 GATA zinc finger DUF1752 PF08550.10 EDO17490.1 - 6.9e-07 29.0 1.5 6.9e-07 29.0 1.5 3.0 3 0 0 3 3 3 1 Fungal protein of unknown function (DUF1752) WDCP PF15390.6 EDO17490.1 - 1.7 6.9 17.1 2.7 6.3 17.1 1.3 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family DUF2781 PF10914.8 EDO17491.1 - 3.1e-42 144.5 6.2 3.7e-42 144.2 6.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2781) HSP9_HSP12 PF04119.12 EDO17492.1 - 4.2e-05 23.8 5.3 0.00035 20.9 1.2 2.4 1 1 1 2 2 2 2 Heat shock protein 9/12 Inhibitor_I34 PF10466.9 EDO17492.1 - 0.0086 16.7 2.2 0.014 16.0 0.0 2.1 1 1 1 2 2 2 1 Saccharopepsin inhibitor I34 DUF1664 PF07889.12 EDO17492.1 - 0.05 13.7 0.4 0.085 12.9 0.4 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) DUF3552 PF12072.8 EDO17492.1 - 0.088 12.2 1.3 0.1 12.0 1.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) WD40 PF00400.32 EDO17494.1 - 1.5e-36 123.7 14.6 1.9e-06 28.5 0.1 7.6 7 0 0 7 7 7 5 WD domain, G-beta repeat CDC4_D PF16856.5 EDO17494.1 - 4.1e-21 74.6 0.2 7.6e-21 73.7 0.2 1.5 1 0 0 1 1 1 1 Cell division control protein 4 dimerisation domain F-box-like PF12937.7 EDO17494.1 - 8.1e-11 41.6 0.9 2e-10 40.4 0.9 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EDO17494.1 - 2.4e-09 36.8 1.0 5.4e-09 35.7 1.0 1.6 1 0 0 1 1 1 1 F-box domain ANAPC4_WD40 PF12894.7 EDO17494.1 - 0.00039 20.7 0.9 0.78 10.1 0.0 4.6 4 2 2 6 6 6 1 Anaphase-promoting complex subunit 4 WD40 domain PRANC PF09372.10 EDO17494.1 - 0.0024 18.1 0.4 0.007 16.7 0.4 1.8 1 0 0 1 1 1 1 PRANC domain Nucleoporin_N PF08801.11 EDO17494.1 - 0.018 13.8 1.7 5.2 5.7 0.1 3.3 2 1 1 3 3 3 0 Nup133 N terminal like JmjC PF02373.22 EDO17494.1 - 0.067 13.6 0.0 0.19 12.1 0.0 1.8 1 0 0 1 1 1 0 JmjC domain, hydroxylase BLM10_mid PF16507.5 EDO17495.1 - 6.9e-159 529.9 20.0 1.3e-158 528.9 20.0 1.5 1 0 0 1 1 1 1 Proteasome-substrate-size regulator, mid region BLM10_N PF16547.5 EDO17495.1 - 8.4e-30 102.9 0.0 2.8e-29 101.2 0.0 2.0 1 0 0 1 1 1 1 Proteasome-substrate-size regulator, N-terminal DUF3437 PF11919.8 EDO17495.1 - 9.2e-25 86.4 0.0 5.2e-24 84.0 0.0 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF3437) DUF424 PF04242.13 EDO17495.1 - 0.035 14.4 2.6 0.12 12.7 0.5 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF424) VTC PF09359.10 EDO17496.1 - 1.2e-95 320.1 0.8 1.2e-95 320.1 0.8 2.5 3 0 0 3 3 3 1 VTC domain SPX PF03105.19 EDO17496.1 - 8.2e-13 49.0 22.1 0.00072 19.6 0.1 4.3 3 1 1 4 4 4 4 SPX domain DUF202 PF02656.15 EDO17496.1 - 2.1e-11 44.1 1.2 3.2e-11 43.5 0.5 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF202) PET122 PF05476.11 EDO17496.1 - 0.15 11.3 3.9 0.21 10.9 1.6 2.2 2 0 0 2 2 2 0 PET122 DUF572 PF04502.13 EDO17496.1 - 0.36 10.4 16.2 0.0099 15.5 8.3 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF572) Peptidase_C48 PF02902.19 EDO17497.1 - 5.1e-35 121.3 0.4 8.3e-35 120.6 0.4 1.3 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain MutS_V PF00488.21 EDO17498.1 - 6.3e-51 173.1 0.2 1.3e-50 172.0 0.2 1.6 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 EDO17498.1 - 1.9e-28 100.0 5.6 1.9e-28 100.0 5.6 2.2 2 0 0 2 2 2 1 MutS domain III MutS_II PF05188.17 EDO17498.1 - 6.5e-07 29.7 0.4 4.2e-06 27.1 0.1 2.6 2 0 0 2 2 2 1 MutS domain II MutS_IV PF05190.18 EDO17498.1 - 1.6e-05 25.1 0.6 1.6e-05 25.1 0.6 3.3 3 0 0 3 3 3 1 MutS family domain IV Melibiase PF02065.18 EDO17498.1 - 0.013 14.5 1.2 0.023 13.7 1.2 1.3 1 0 0 1 1 1 0 Melibiase NFACT-C PF11923.8 EDO17499.1 - 3.7e-32 110.4 0.4 3.7e-32 110.4 0.4 4.3 4 1 1 5 5 5 1 NFACT protein C-terminal domain NFACT-R_1 PF05670.13 EDO17499.1 - 4.1e-17 62.8 0.0 1.5e-16 61.0 0.0 2.1 1 0 0 1 1 1 1 NFACT protein RNA binding domain FbpA PF05833.11 EDO17499.1 - 4.3e-17 62.0 35.8 4.3e-17 62.0 35.8 3.4 2 1 0 2 2 2 1 Fibronectin-binding protein A N-terminus (FbpA) MIT_C PF16565.5 EDO17499.1 - 0.069 13.1 0.1 0.069 13.1 0.1 2.7 2 0 0 2 2 2 0 Phospholipase D-like domain at C-terminus of MIT Clat_adaptor_s PF01217.20 EDO17500.1 - 8.3e-16 58.2 0.2 1.2e-15 57.6 0.2 1.2 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Glyco_transf_25 PF01755.17 EDO17500.1 - 0.039 13.8 0.3 0.07 13.0 0.3 1.4 1 0 0 1 1 1 0 Glycosyltransferase family 25 (LPS biosynthesis protein) Bromo_TP PF07524.13 EDO17501.1 - 7.7e-06 25.8 0.1 1.6e-05 24.8 0.1 1.5 1 0 0 1 1 1 1 Bromodomain associated Acyltransf_C PF16076.5 EDO17501.1 - 0.02 15.0 2.0 5.2 7.2 0.1 3.4 2 1 1 3 3 3 0 Acyltransferase C-terminus TFIID-31kDa PF02291.15 EDO17501.1 - 0.02 15.0 0.7 0.078 13.0 0.1 2.1 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit NUC173 PF08161.12 EDO17502.1 - 5.3e-75 251.6 0.5 1.9e-71 239.9 0.2 3.8 3 0 0 3 3 3 2 NUC173 domain HEAT PF02985.22 EDO17502.1 - 1.9e-05 24.5 1.8 0.14 12.5 0.0 5.4 5 0 0 5 5 5 1 HEAT repeat HEAT_2 PF13646.6 EDO17502.1 - 0.0053 17.1 0.1 4.5 7.7 0.0 3.8 3 1 0 3 3 3 1 HEAT repeats Vac14_Fab1_bd PF12755.7 EDO17502.1 - 0.061 13.9 3.1 2.6 8.7 0.0 4.4 5 0 0 5 5 5 0 Vacuolar 14 Fab1-binding region Nipped-B_C PF12830.7 EDO17502.1 - 0.085 12.8 1.9 4.9 7.0 0.1 3.2 3 0 0 3 3 3 0 Sister chromatid cohesion C-terminus UME PF08064.13 EDO17502.1 - 1.6 8.7 11.4 1.4 8.9 0.1 4.7 5 1 0 5 5 5 0 UME (NUC010) domain CLASP_N PF12348.8 EDO17502.1 - 7.7 6.0 13.3 1.4 8.5 1.3 4.4 4 1 0 6 6 6 0 CLASP N terminal Ribosomal_S16 PF00886.19 EDO17503.1 - 6.4e-25 87.0 0.0 8.4e-25 86.6 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein S16 PDR_assoc PF08370.11 EDO17503.1 - 0.069 12.9 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 Plant PDR ABC transporter associated ThiF PF00899.21 EDO17505.1 - 0.039 13.3 0.0 6 6.1 0.0 2.5 2 0 0 2 2 2 0 ThiF family DEAD PF00270.29 EDO17506.1 - 7.8e-40 136.5 0.1 3.7e-39 134.3 0.1 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDO17506.1 - 1.1e-23 83.7 0.1 1.5e-22 80.0 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 EDO17506.1 - 7.2e-16 58.2 0.2 1.5e-15 57.1 0.2 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 EDO17506.1 - 9.3e-07 29.0 0.0 9.3e-07 29.0 0.0 2.1 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 EDO17506.1 - 0.0062 15.8 0.0 0.0062 15.8 0.0 2.1 2 0 0 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase CMS1 PF14617.6 EDO17506.1 - 0.046 13.0 0.0 0.046 13.0 0.0 2.5 2 0 0 2 2 2 0 U3-containing 90S pre-ribosomal complex subunit PseudoU_synth_1 PF01416.20 EDO17507.1 - 6.7e-34 116.6 0.0 2.4e-30 105.2 0.0 2.6 2 1 0 2 2 2 2 tRNA pseudouridine synthase Hat1_N PF10394.9 EDO17508.1 - 1.2e-41 142.7 3.9 2.3e-41 141.7 3.9 1.5 1 0 0 1 1 1 1 Histone acetyl transferase HAT1 N-terminus Acetyltransf_1 PF00583.25 EDO17508.1 - 4.5e-06 26.9 0.0 2.4e-05 24.5 0.0 2.1 1 1 1 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EDO17508.1 - 0.023 14.6 0.0 0.081 12.9 0.0 1.9 1 1 1 2 2 2 0 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EDO17508.1 - 0.041 14.3 0.0 0.09 13.2 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain NfI_DNAbd_pre-N PF10524.9 EDO17508.1 - 0.05 13.5 0.3 0.14 12.1 0.3 1.8 1 0 0 1 1 1 0 Nuclear factor I protein pre-N-terminus DUF276 PF03434.13 EDO17510.1 - 0.0052 16.0 0.7 0.0085 15.3 0.7 1.3 1 0 0 1 1 1 1 DUF276 DUF2863 PF11062.8 EDO17510.1 - 0.12 10.8 0.2 0.18 10.2 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2863) Nic96 PF04097.14 EDO17511.1 - 6.3e-41 140.5 8.4 7.1e-41 140.4 8.4 1.0 1 0 0 1 1 1 1 Nup93/Nic96 GCIP PF13324.6 EDO17511.1 - 0.0085 15.7 3.9 0.018 14.6 0.9 1.9 1 1 1 2 2 2 1 Grap2 and cyclin-D-interacting Alpha-E PF04168.12 EDO17511.1 - 0.013 15.4 0.6 0.02 14.7 0.6 1.3 1 1 0 1 1 1 0 A predicted alpha-helical domain with a conserved ER motif. DUF2150 PF09920.9 EDO17511.1 - 0.13 12.2 1.9 0.38 10.7 1.9 1.7 1 1 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2150) PPI_Ypi1 PF07491.11 EDO17512.1 - 7.2e-07 28.9 15.5 7.2e-07 28.9 15.5 2.5 2 2 0 2 2 2 1 Protein phosphatase inhibitor Dehydrin PF00257.19 EDO17512.1 - 0.19 12.3 8.4 0.32 11.5 8.4 1.5 1 1 0 1 1 1 0 Dehydrin Cyto_heme_lyase PF01265.17 EDO17513.1 - 2.1e-63 214.6 3.6 1.1e-62 212.2 3.6 1.8 1 1 0 1 1 1 1 Cytochrome c/c1 heme lyase SRR PF07709.11 EDO17514.1 - 0.15 12.5 0.9 4.9 8.0 0.5 3.3 2 0 0 2 2 2 0 Seven Residue Repeat DUF166 PF02593.14 EDO17515.1 - 0.046 13.3 0.5 0.071 12.6 0.5 1.3 1 0 0 1 1 1 0 Domain of unknown function RPA_interact_M PF14767.6 EDO17515.1 - 0.22 12.1 3.1 0.86 10.2 3.1 2.0 1 0 0 1 1 1 0 Replication protein A interacting middle Fib_alpha PF08702.10 EDO17515.1 - 6.8 6.9 18.7 2.4 8.3 0.9 2.5 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family DEAD PF00270.29 EDO17516.1 - 1.4e-34 119.4 0.2 2.5e-34 118.6 0.0 1.5 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDO17516.1 - 2.5e-27 95.4 0.1 1.7e-25 89.5 0.3 2.6 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDO17516.1 - 3.6e-08 33.6 0.0 7.4e-08 32.6 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Pyr_redox_2 PF07992.14 EDO17517.1 - 2.2e-47 161.7 0.0 2.8e-47 161.4 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EDO17517.1 - 2.5e-08 34.3 0.0 5.2e-07 30.1 0.0 2.9 3 1 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EDO17517.1 - 0.004 16.5 0.1 1.1 8.5 0.0 2.7 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EDO17517.1 - 0.012 14.8 0.0 0.021 14.0 0.0 1.3 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) DLH PF01738.18 EDO17518.1 - 3.3e-25 88.9 0.0 4.4e-25 88.5 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family Peptidase_S9 PF00326.21 EDO17518.1 - 5.7e-05 22.7 0.2 0.0011 18.5 0.0 2.3 3 0 0 3 3 3 1 Prolyl oligopeptidase family LIDHydrolase PF10230.9 EDO17518.1 - 0.015 14.8 0.0 0.022 14.3 0.0 1.2 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase Chlorophyllase2 PF12740.7 EDO17518.1 - 0.041 12.8 0.0 0.056 12.3 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase enzyme Chlorophyllase PF07224.11 EDO17518.1 - 0.045 12.8 0.0 0.057 12.4 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase BAAT_C PF08840.11 EDO17518.1 - 0.17 11.8 0.0 0.23 11.3 0.0 1.2 1 0 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal adh_short PF00106.25 EDO17519.1 - 3.4e-10 39.7 0.0 3.7e-08 33.1 0.1 2.3 2 0 0 2 2 2 2 short chain dehydrogenase KR PF08659.10 EDO17519.1 - 0.0029 17.6 1.1 0.017 15.1 1.1 1.9 1 1 0 1 1 1 1 KR domain adh_short_C2 PF13561.6 EDO17519.1 - 0.0046 16.5 0.0 0.019 14.5 0.0 1.8 1 1 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 EDO17519.1 - 0.024 14.1 0.0 0.037 13.5 0.0 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family 3HCDH_N PF02737.18 EDO17519.1 - 0.099 12.5 0.2 0.17 11.7 0.2 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain CRC_subunit PF08624.10 EDO17520.1 - 1.8e-47 161.2 0.0 8.3e-47 159.0 0.0 2.0 2 0 0 2 2 2 1 Chromatin remodelling complex Rsc7/Swp82 subunit Hap4_Hap_bind PF10297.9 EDO17521.1 - 4.6e-09 36.1 6.3 9.5e-09 35.1 6.3 1.5 1 0 0 1 1 1 1 Minimal binding motif of Hap4 for binding to Hap2/3/5 DUF4587 PF15248.6 EDO17521.1 - 1.4 9.8 6.1 3.3 8.6 6.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4587) Glyco_hydro_38N PF01074.22 EDO17522.1 - 4e-80 269.3 0.4 6.8e-80 268.5 0.4 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 N-terminal domain Glyco_hydro_38C PF07748.13 EDO17522.1 - 1e-54 185.9 0.2 2.2e-54 184.8 0.1 1.7 2 0 0 2 2 2 1 Glycosyl hydrolases family 38 C-terminal domain Alpha-mann_mid PF09261.11 EDO17522.1 - 6.5e-21 74.3 0.0 1.6e-20 73.1 0.0 1.7 1 0 0 1 1 1 1 Alpha mannosidase middle domain Glyco_hydro38C2 PF17677.1 EDO17522.1 - 6e-09 35.9 0.0 2.7e-08 33.8 0.0 2.1 1 1 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal beta sandwich domain Prenyltrans PF00432.21 EDO17523.1 - 1.4e-28 98.3 0.2 3.5e-07 29.8 0.1 4.9 5 0 0 5 5 5 4 Prenyltransferase and squalene oxidase repeat Pex14_N PF04695.13 EDO17524.1 - 3.8e-29 102.4 4.7 3.8e-29 102.4 4.7 3.5 3 1 0 3 3 3 1 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF1664 PF07889.12 EDO17524.1 - 0.00036 20.5 1.6 0.00088 19.3 1.1 1.9 1 1 0 1 1 1 1 Protein of unknown function (DUF1664) Baculo_PEP_C PF04513.12 EDO17524.1 - 0.00039 20.5 3.6 0.00089 19.3 3.6 1.6 1 0 0 1 1 1 1 Baculovirus polyhedron envelope protein, PEP, C terminus ATG16 PF08614.11 EDO17524.1 - 0.0039 17.4 6.5 0.016 15.4 6.5 2.0 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) Spc7 PF08317.11 EDO17524.1 - 0.021 13.7 13.3 0.041 12.8 13.3 1.4 1 0 0 1 1 1 0 Spc7 kinetochore protein Prominin PF05478.11 EDO17524.1 - 0.041 11.8 2.4 0.049 11.6 2.4 1.1 1 0 0 1 1 1 0 Prominin RsbRD_N PF14361.6 EDO17524.1 - 0.057 14.1 0.5 0.2 12.3 0.5 2.0 1 0 0 1 1 1 0 RsbT co-antagonist protein rsbRD N-terminal domain APG6_N PF17675.1 EDO17524.1 - 0.058 13.9 16.3 2.1 8.9 16.3 2.7 1 1 0 1 1 1 0 Apg6 coiled-coil region MbeD_MobD PF04899.12 EDO17524.1 - 0.072 13.2 1.9 0.19 11.9 1.9 1.7 1 0 0 1 1 1 0 MbeD/MobD like DUF4200 PF13863.6 EDO17524.1 - 0.079 13.4 9.6 0.27 11.6 9.6 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) THOC7 PF05615.13 EDO17524.1 - 0.1 12.9 9.9 0.16 12.2 8.5 2.0 1 1 1 2 2 2 0 Tho complex subunit 7 DUF948 PF06103.11 EDO17524.1 - 0.16 12.2 3.2 1.9 8.8 0.5 2.6 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) Nup88 PF10168.9 EDO17524.1 - 0.16 9.7 8.1 0.24 9.2 8.1 1.2 1 0 0 1 1 1 0 Nuclear pore component PI3K_P85_iSH2 PF16454.5 EDO17524.1 - 0.21 11.2 11.7 0.75 9.4 8.0 2.9 2 1 0 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain FlgN PF05130.12 EDO17524.1 - 0.28 11.7 8.8 0.63 10.6 8.8 1.5 1 0 0 1 1 1 0 FlgN protein V_ATPase_I PF01496.19 EDO17524.1 - 0.38 8.6 6.8 0.47 8.3 6.8 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF892 PF05974.12 EDO17524.1 - 0.39 10.7 6.9 2.5 8.1 3.3 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF892) TMPIT PF07851.13 EDO17524.1 - 0.39 9.9 7.0 0.63 9.2 7.0 1.4 1 0 0 1 1 1 0 TMPIT-like protein Golgin_A5 PF09787.9 EDO17524.1 - 0.41 10.1 15.3 0.08 12.4 11.5 1.7 2 0 0 2 2 2 0 Golgin subfamily A member 5 COG2 PF06148.11 EDO17524.1 - 0.42 10.7 5.9 4.7 7.3 3.5 2.5 1 1 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Plasmid_RAQPRD PF09686.10 EDO17524.1 - 0.47 10.7 3.4 16 5.8 0.0 3.4 1 1 2 3 3 3 0 Plasmid protein of unknown function (Plasmid_RAQPRD) DUF1043 PF06295.12 EDO17524.1 - 0.82 9.7 9.9 4.5 7.3 9.2 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1043) KxDL PF10241.9 EDO17524.1 - 1.1 9.6 8.8 6.6 7.1 2.5 3.0 1 1 2 3 3 3 0 Uncharacterized conserved protein NPV_P10 PF05531.12 EDO17524.1 - 1.2 9.6 6.7 2.6 8.6 1.5 2.8 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein UPF0184 PF03670.13 EDO17524.1 - 2 8.9 7.0 19 5.7 5.4 2.9 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0184) V-SNARE PF05008.15 EDO17524.1 - 2.3 8.6 10.3 2.6 8.5 5.0 3.1 1 1 2 3 3 3 0 Vesicle transport v-SNARE protein N-terminus CCDC-167 PF15188.6 EDO17524.1 - 2.8 8.3 12.4 1.4 9.3 2.0 3.0 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 167 EMP24_GP25L PF01105.24 EDO17524.1 - 3.5 7.5 9.7 1.4 8.8 5.0 2.2 1 1 1 2 2 2 0 emp24/gp25L/p24 family/GOLD DUF4164 PF13747.6 EDO17524.1 - 3.6 7.9 10.7 0.89 9.9 0.2 2.8 2 1 1 3 3 2 0 Domain of unknown function (DUF4164) Prefoldin_2 PF01920.20 EDO17524.1 - 5.2 7.1 17.1 5.1 7.1 7.5 3.3 1 1 1 2 2 2 0 Prefoldin subunit FlaC_arch PF05377.11 EDO17524.1 - 5.6 7.4 13.5 1.9 8.9 2.5 4.7 2 1 3 5 5 5 0 Flagella accessory protein C (FlaC) Syntaxin-6_N PF09177.11 EDO17524.1 - 6 7.5 16.6 9.1 6.9 8.9 3.6 3 1 1 4 4 4 0 Syntaxin 6, N-terminal GTP-bdg_M PF16360.5 EDO17524.1 - 6 7.5 5.8 21 5.8 1.2 2.9 1 1 1 2 2 2 0 GTP-binding GTPase Middle Region Med5 PF08689.10 EDO17525.1 - 0 1470.7 60.3 0 1470.5 60.3 1.0 1 0 0 1 1 1 1 Mediator complex subunit Med5 SNF2_N PF00176.23 EDO17526.1 - 8.4e-67 225.4 1.0 8.4e-67 225.4 1.0 2.8 3 0 0 3 3 3 1 SNF2 family N-terminal domain DBINO PF13892.6 EDO17526.1 - 4.5e-45 153.3 19.5 4.5e-45 153.3 19.5 5.7 6 0 0 6 6 6 1 DNA-binding domain Helicase_C PF00271.31 EDO17526.1 - 2.5e-17 63.2 0.1 1.9e-16 60.4 0.0 2.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain RHH_4 PF13467.6 EDO17526.1 - 0.048 13.5 0.0 0.13 12.1 0.0 1.7 1 0 0 1 1 1 0 Ribbon-helix-helix domain SH3_9 PF14604.6 EDO17527.1 - 4.7e-05 23.2 0.1 0.00012 21.8 0.1 1.8 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EDO17527.1 - 0.0016 18.0 0.1 0.0016 18.0 0.1 2.7 3 0 0 3 3 3 1 SH3 domain Transglut_core PF01841.19 EDO17527.1 - 0.013 16.0 0.0 0.026 14.9 0.0 1.5 1 0 0 1 1 1 0 Transglutaminase-like superfamily Iwr1 PF08574.10 EDO17528.1 - 1.2e-13 51.9 13.5 1.2e-13 51.9 13.5 3.8 2 1 1 3 3 3 1 Transcription factor Iwr1 adh_short PF00106.25 EDO17529.1 - 2.5e-41 141.3 0.0 3.5e-41 140.8 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EDO17529.1 - 1.3e-26 93.6 0.0 2.6e-26 92.6 0.0 1.5 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EDO17529.1 - 3.5e-11 43.3 0.0 1.9e-10 41.0 0.0 1.9 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 EDO17529.1 - 0.00017 21.1 0.0 0.00027 20.5 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RNase_PH PF01138.21 EDO17530.1 - 1.2e-11 45.3 0.2 1.6e-11 44.8 0.2 1.2 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 EDO17530.1 - 0.068 13.2 0.0 0.17 12.0 0.0 1.7 1 0 0 1 1 1 0 3' exoribonuclease family, domain 2 EMP24_GP25L PF01105.24 EDO17531.1 - 1.7e-08 34.7 1.6 2.3e-08 34.2 1.6 1.2 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD BLOC1_2 PF10046.9 EDO17532.1 - 0.005 17.1 1.0 3.2 8.1 0.3 2.4 2 1 0 2 2 2 2 Biogenesis of lysosome-related organelles complex-1 subunit 2 FAM184 PF15665.5 EDO17532.1 - 0.015 15.1 0.1 0.018 14.8 0.1 1.1 1 0 0 1 1 1 0 Family with sequence similarity 184, A and B Spc7 PF08317.11 EDO17532.1 - 0.018 13.9 1.1 0.024 13.5 1.1 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF4635 PF15466.6 EDO17532.1 - 0.032 13.7 0.2 0.061 12.8 0.0 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4635) betaPIX_CC PF16523.5 EDO17532.1 - 0.037 13.8 3.7 2.2 8.1 0.5 2.4 1 1 1 2 2 2 0 betaPIX coiled coil DUF676 PF05057.14 EDO17533.1 - 2.2e-58 197.3 0.1 4.1e-58 196.5 0.1 1.4 1 0 0 1 1 1 1 Putative serine esterase (DUF676) LCAT PF02450.15 EDO17533.1 - 0.0052 16.0 0.0 0.0099 15.1 0.0 1.4 1 0 0 1 1 1 1 Lecithin:cholesterol acyltransferase Lipase_3 PF01764.25 EDO17533.1 - 0.019 14.8 0.0 0.041 13.7 0.0 1.5 1 0 0 1 1 1 0 Lipase (class 3) PGAP1 PF07819.13 EDO17533.1 - 0.029 14.1 0.0 0.074 12.7 0.0 1.7 1 0 0 1 1 1 0 PGAP1-like protein Abhydrolase_5 PF12695.7 EDO17533.1 - 0.046 13.5 0.0 0.13 12.0 0.0 1.7 2 0 0 2 2 2 0 Alpha/beta hydrolase family PCRF PF03462.18 EDO17534.1 - 4.1e-53 180.1 0.3 1.3e-51 175.2 0.0 2.2 2 0 0 2 2 2 1 PCRF domain RF-1 PF00472.20 EDO17534.1 - 3.9e-38 130.0 2.7 9.2e-38 128.8 2.7 1.6 1 0 0 1 1 1 1 RF-1 domain Pkinase PF00069.25 EDO17535.1 - 6.1e-74 248.7 0.0 7.1e-74 248.5 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO17535.1 - 3.7e-30 105.1 0.0 5.4e-30 104.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDO17535.1 - 0.00072 19.0 0.0 0.0015 17.9 0.0 1.6 1 1 0 1 1 1 1 Kinase-like APH PF01636.23 EDO17535.1 - 0.0058 16.6 0.1 0.0094 15.9 0.1 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EDO17535.1 - 0.075 12.0 0.0 0.28 10.1 0.0 1.8 1 1 0 1 1 1 0 Haspin like kinase domain TPR_2 PF07719.17 EDO17536.1 - 1.8e-07 30.8 3.6 0.0039 17.2 0.0 4.4 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_8 PF13181.6 EDO17536.1 - 0.00053 20.0 2.2 0.95 9.8 0.0 4.2 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_12 PF13424.6 EDO17536.1 - 0.00087 19.5 0.0 0.0033 17.7 0.0 2.0 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_7 PF13176.6 EDO17536.1 - 0.0074 16.2 0.1 8.9 6.6 0.0 3.1 2 0 0 2 2 2 2 Tetratricopeptide repeat RNA_pol_A_CTD PF03118.15 EDO17536.1 - 0.016 15.0 0.0 0.14 11.9 0.0 2.4 2 0 0 2 2 2 0 Bacterial RNA polymerase, alpha chain C terminal domain TPR_1 PF00515.28 EDO17536.1 - 0.031 14.1 5.1 1.7 8.6 0.0 4.2 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_14 PF13428.6 EDO17536.1 - 0.19 12.6 0.0 6.2 7.9 0.0 2.7 1 1 1 2 2 2 0 Tetratricopeptide repeat Glyco_transf_22 PF03901.17 EDO17537.1 - 1.3e-103 347.5 35.7 1.6e-103 347.1 35.7 1.0 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family HECT PF00632.25 EDO17538.1 - 2.5e-88 296.5 0.8 5.7e-88 295.3 0.8 1.6 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Aldedh PF00171.22 EDO17539.1 - 5.2e-148 493.4 0.0 5.9e-148 493.2 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.14 EDO17539.1 - 0.11 11.5 0.0 7.3 5.5 0.0 2.2 2 0 0 2 2 2 0 Acyl-CoA reductase (LuxC) SHE3 PF17078.5 EDO17540.1 - 3.5e-84 282.1 39.0 3.5e-84 282.1 39.0 1.9 2 0 0 2 2 2 1 SWI5-dependent HO expression protein 3 Tup_N PF08581.10 EDO17540.1 - 0.003 17.8 10.8 0.003 17.8 10.8 3.2 2 1 1 3 3 3 1 Tup N-terminal DUF948 PF06103.11 EDO17540.1 - 0.0069 16.6 0.7 0.0069 16.6 0.7 3.3 2 1 1 3 3 3 1 Bacterial protein of unknown function (DUF948) DUF3584 PF12128.8 EDO17540.1 - 0.0084 13.7 23.3 0.011 13.3 23.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) Spc7 PF08317.11 EDO17540.1 - 0.15 10.9 31.0 0.077 11.9 17.0 2.3 1 1 1 2 2 2 0 Spc7 kinetochore protein Spectrin PF00435.21 EDO17540.1 - 0.43 11.1 18.9 0.51 10.9 2.2 3.0 1 1 2 3 3 3 0 Spectrin repeat Filament PF00038.21 EDO17540.1 - 0.86 9.1 35.3 4.5 6.8 35.2 2.1 1 1 0 1 1 1 0 Intermediate filament protein DUF3450 PF11932.8 EDO17540.1 - 0.88 8.8 26.0 0.18 11.1 6.0 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF3450) CREPT PF16566.5 EDO17540.1 - 1.2 9.3 18.7 3.1 8.0 6.1 3.1 1 1 1 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour Jnk-SapK_ap_N PF09744.9 EDO17540.1 - 3 8.1 37.0 0.1 12.9 16.3 3.4 2 1 1 3 3 3 0 JNK_SAPK-associated protein-1 AI-2E_transport PF01594.16 EDO17540.1 - 4.6 6.3 7.2 2.3 7.3 1.8 2.3 2 0 0 2 2 2 0 AI-2E family transporter DUF4164 PF13747.6 EDO17540.1 - 4.6 7.6 15.7 0.55 10.5 6.4 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF4164) COMMD1_N PF17221.3 EDO17540.1 - 6.1 7.2 9.2 4.2 7.7 1.8 2.5 1 1 1 2 2 2 0 COMMD1 N-terminal domain Atg14 PF10186.9 EDO17541.1 - 1.7e-25 89.8 11.8 3.5e-25 88.8 11.8 1.5 1 1 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 DUF2853 PF11015.8 EDO17541.1 - 0.033 14.9 0.1 0.033 14.9 0.1 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF2853) DUF848 PF05852.11 EDO17541.1 - 0.13 12.3 4.6 0.26 11.4 4.6 1.4 1 0 0 1 1 1 0 Gammaherpesvirus protein of unknown function (DUF848) IZUMO PF15005.6 EDO17541.1 - 1.2 9.6 7.3 1.7 9.2 3.2 2.5 1 1 1 2 2 2 0 Izumo sperm-egg fusion, Ig domain-associated zf-C4pol PF14260.6 EDO17541.1 - 2 8.9 6.9 0.39 11.2 0.8 2.6 2 1 0 2 2 2 0 C4-type zinc-finger of DNA polymerase delta AA_permease PF00324.21 EDO17543.1 - 3.9e-122 408.3 42.8 4.5e-122 408.1 42.8 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EDO17543.1 - 9.6e-33 113.6 45.3 1.2e-32 113.3 45.3 1.1 1 0 0 1 1 1 1 Amino acid permease UCH PF00443.29 EDO17544.1 - 8.1e-50 169.7 3.8 1e-49 169.3 3.8 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EDO17544.1 - 1.7e-13 50.9 11.4 2.7e-12 46.9 11.4 2.1 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase ubiquitin PF00240.23 EDO17544.1 - 5.3e-06 26.1 0.1 2.5e-05 23.9 0.0 2.3 2 0 0 2 2 2 1 Ubiquitin family GSHPx PF00255.19 EDO17545.1 - 2.2e-45 152.7 0.2 3e-45 152.2 0.2 1.2 1 0 0 1 1 1 1 Glutathione peroxidase Redoxin PF08534.10 EDO17545.1 - 1.8e-05 24.5 0.0 5.6e-05 22.9 0.0 1.8 1 1 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 EDO17545.1 - 0.0025 17.7 0.1 0.0093 15.9 0.1 2.0 1 1 0 1 1 1 1 AhpC/TSA family WD40 PF00400.32 EDO17546.1 - 5.5e-22 77.6 11.9 0.00026 21.7 0.1 5.6 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDO17546.1 - 9.1e-13 48.3 0.5 0.0062 16.8 0.0 4.1 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EDO17546.1 - 9.6e-05 21.5 0.5 4.2 6.2 0.0 4.4 2 1 2 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein YmzC PF14157.6 EDO17546.1 - 0.0011 19.0 0.0 4.9 7.3 0.0 3.8 4 0 0 4 4 4 2 YmzC-like protein Glycos_transf_4 PF00953.21 EDO17547.1 - 4.7e-31 107.9 10.3 4.7e-31 107.9 10.3 2.2 3 0 0 3 3 3 1 Glycosyl transferase family 4 DUF3413 PF11893.8 EDO17547.1 - 0.5 9.5 10.4 0.023 13.9 3.9 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3413) Sugar_tr PF00083.24 EDO17548.1 - 5.7e-96 322.1 25.1 7.7e-96 321.7 25.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDO17548.1 - 5.1e-33 114.5 44.9 7.6e-31 107.3 24.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Oxidored_q2 PF00420.24 EDO17548.1 - 9.2 6.0 14.5 10 5.8 5.8 3.5 3 0 0 3 3 3 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L Zn_clus PF00172.18 EDO17549.1 - 5.2e-09 36.1 9.6 5.2e-09 36.1 9.6 1.9 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MVP_shoulder PF11978.8 EDO17549.1 - 0.012 15.6 1.3 0.038 14.0 0.2 2.2 2 0 0 2 2 2 0 Shoulder domain DEAD PF00270.29 EDO17551.1 - 5.7e-48 163.0 0.5 1.7e-47 161.5 0.2 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDO17551.1 - 1.6e-22 79.9 0.2 5.7e-21 74.9 0.0 3.3 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDO17551.1 - 6.1e-08 32.8 0.0 6.1e-08 32.8 0.0 3.9 4 1 0 4 4 4 1 Type III restriction enzyme, res subunit Pox_MCEL PF03291.16 EDO17552.1 - 5.4e-101 338.0 0.2 7.6e-101 337.5 0.2 1.2 1 0 0 1 1 1 1 mRNA capping enzyme Methyltransf_25 PF13649.6 EDO17552.1 - 5.4e-11 43.0 0.0 1.2e-10 41.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EDO17552.1 - 9.9e-09 35.8 0.0 5.8e-08 33.4 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EDO17552.1 - 3.2e-08 34.1 0.0 1.2e-07 32.3 0.0 2.0 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 EDO17552.1 - 2.6e-06 27.4 0.0 5e-06 26.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDO17552.1 - 4.1e-06 26.7 0.1 8.3e-06 25.7 0.1 1.7 1 1 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 EDO17552.1 - 0.031 13.6 1.2 0.068 12.4 0.0 1.9 2 0 0 2 2 2 0 Mycolic acid cyclopropane synthetase Methyltransf_4 PF02390.17 EDO17552.1 - 0.033 13.6 0.6 0.063 12.7 0.0 1.7 2 0 0 2 2 2 0 Putative methyltransferase TPMT PF05724.11 EDO17552.1 - 0.056 13.1 0.0 0.11 12.1 0.0 1.5 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) NNMT_PNMT_TEMT PF01234.17 EDO17552.1 - 0.061 12.5 0.0 0.15 11.2 0.0 1.6 1 0 0 1 1 1 0 NNMT/PNMT/TEMT family MetW PF07021.12 EDO17552.1 - 0.12 12.0 0.0 0.24 11.0 0.0 1.4 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW AA_permease PF00324.21 EDO17553.1 - 1.3e-45 155.9 37.6 1.8e-45 155.5 37.6 1.1 1 0 0 1 1 1 1 Amino acid permease SLC12 PF03522.15 EDO17553.1 - 9.4e-18 64.4 4.2 3.3e-08 33.0 0.0 3.3 3 0 0 3 3 3 3 Solute carrier family 12 FIIND PF13553.6 EDO17554.1 - 0.052 12.9 0.1 0.1 12.0 0.1 1.4 1 0 0 1 1 1 0 Function to find KH_1 PF00013.29 EDO17555.1 - 7.8e-38 128.1 3.9 1.3e-12 47.3 0.2 3.4 3 0 0 3 3 3 3 KH domain KH_2 PF07650.17 EDO17555.1 - 1.2e-08 34.6 0.2 0.21 11.4 0.0 3.5 3 0 0 3 3 3 3 KH domain KH_4 PF13083.6 EDO17555.1 - 2.4e-06 27.3 0.1 0.036 13.9 0.0 3.4 3 0 0 3 3 3 2 KH domain KH_5 PF13184.6 EDO17555.1 - 0.0094 16.0 2.0 4.5 7.4 0.3 3.5 3 0 0 3 3 3 2 NusA-like KH domain ABC1 PF03109.16 EDO17556.1 - 8e-38 129.3 0.0 1.8e-37 128.1 0.0 1.6 1 0 0 1 1 1 1 ABC1 family Pkinase PF00069.25 EDO17556.1 - 0.054 12.9 0.0 0.12 11.8 0.0 1.5 1 0 0 1 1 1 0 Protein kinase domain OB_NTP_bind PF07717.16 EDO17557.1 - 3.3e-23 81.8 0.0 1.3e-22 79.9 0.0 2.1 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.23 EDO17557.1 - 5.7e-22 78.0 0.0 1.3e-21 76.9 0.0 1.6 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.31 EDO17557.1 - 3.9e-12 46.5 0.0 1.1e-11 45.0 0.0 1.8 2 0 0 2 2 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 EDO17557.1 - 6.9e-11 42.2 0.4 1.2e-10 41.5 0.4 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 EDO17557.1 - 5.6e-07 29.9 0.3 1.4e-06 28.6 0.1 1.8 2 0 0 2 2 2 1 AAA domain SRP54 PF00448.22 EDO17557.1 - 1.2e-05 25.1 0.3 3.1e-05 23.7 0.3 1.6 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain AAA_19 PF13245.6 EDO17557.1 - 7.9e-05 23.0 0.2 0.00016 22.1 0.2 1.4 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EDO17557.1 - 0.00019 21.2 0.0 0.00033 20.4 0.0 1.3 1 0 0 1 1 1 1 AAA domain Flavi_DEAD PF07652.14 EDO17557.1 - 0.00024 21.1 0.2 0.00044 20.2 0.2 1.4 1 0 0 1 1 1 1 Flavivirus DEAD domain ResIII PF04851.15 EDO17557.1 - 0.0022 18.0 0.2 0.67 9.9 0.0 2.4 1 1 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_23 PF13476.6 EDO17557.1 - 0.0036 17.8 0.1 0.022 15.2 0.0 2.1 2 0 0 2 2 2 1 AAA domain DUF2075 PF09848.9 EDO17557.1 - 0.027 13.7 0.0 0.039 13.2 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_7 PF12775.7 EDO17557.1 - 0.027 14.0 0.1 0.091 12.3 0.0 1.9 2 0 0 2 2 2 0 P-loop containing dynein motor region T2SSE PF00437.20 EDO17557.1 - 0.12 11.4 0.0 0.25 10.4 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_33 PF13671.6 EDO17557.1 - 0.18 12.0 0.3 0.89 9.7 0.1 2.3 2 1 0 2 2 2 0 AAA domain Nab2 PF11517.8 EDO17558.1 - 7.1e-48 161.1 4.5 1.1e-47 160.5 4.5 1.3 1 0 0 1 1 1 1 Nuclear abundant poly(A) RNA-bind protein 2 (Nab2) zf-CCCH_2 PF14608.6 EDO17558.1 - 2.3e-17 62.7 73.5 5.4e-06 26.7 4.3 7.1 7 0 0 7 7 7 5 RNA-binding, Nab2-type zinc finger Nab2p_Zf1 PF18260.1 EDO17558.1 - 4.4e-16 58.5 9.9 4.4e-16 58.5 9.9 3.3 3 0 0 3 3 3 1 Nuclear polyadenylated RNA-binding 2 protein CCCH zinc finger 1 TFIIA PF03153.13 EDO17558.1 - 0.00087 19.4 14.9 0.0014 18.7 14.9 1.3 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit FAP PF07174.11 EDO17558.1 - 0.0023 17.4 13.8 0.0023 17.4 13.8 1.9 3 0 0 3 3 3 1 Fibronectin-attachment protein (FAP) DUF2508 PF10704.9 EDO17558.1 - 0.02 15.0 0.4 0.045 13.9 0.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2508) Nucleo_P87 PF07267.11 EDO17558.1 - 0.022 13.6 7.2 0.037 12.9 7.2 1.3 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 FAM70 PF14967.6 EDO17558.1 - 1.3 8.5 5.6 2.8 7.3 5.6 1.5 1 0 0 1 1 1 0 FAM70 protein Amelogenin PF02948.15 EDO17558.1 - 1.6 9.3 27.9 0.067 13.8 18.6 2.8 3 0 0 3 3 3 0 Amelogenin LcrG PF07216.12 EDO17558.1 - 2 8.4 6.4 19 5.2 1.9 2.6 2 0 0 2 2 2 0 LcrG protein Ribosomal_S5 PF00333.20 EDO17559.1 - 2.8e-26 91.3 2.2 1.9e-25 88.6 1.5 2.3 2 0 0 2 2 2 1 Ribosomal protein S5, N-terminal domain Ribosomal_S5_C PF03719.15 EDO17559.1 - 4.8e-23 80.4 0.0 8.3e-23 79.6 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain FoP_duplication PF13865.6 EDO17559.1 - 4.3 7.9 12.3 0.48 11.0 8.1 1.6 2 0 0 2 2 2 0 C-terminal duplication domain of Friend of PRMT1 Zip PF02535.22 EDO17560.1 - 4.2 6.5 16.4 0.78 8.9 2.1 2.3 2 1 0 2 2 2 0 ZIP Zinc transporter Glyco_hydro_31 PF01055.26 EDO17561.1 - 1.8e-123 413.0 0.6 2.6e-123 412.5 0.0 1.6 2 0 0 2 2 2 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.6 EDO17561.1 - 9.9e-26 89.9 1.8 4.7e-25 87.7 0.2 3.0 3 0 0 3 3 3 1 Galactose mutarotase-like DUF5110 PF17137.4 EDO17561.1 - 6.3e-08 32.8 0.2 2.7e-07 30.7 0.2 2.1 1 0 0 1 1 1 1 Domain of unknown function (DUF5110) DUF5341 PF17276.2 EDO17561.1 - 0.1 12.8 3.3 0.08 13.1 0.4 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5341) Tyr-DNA_phospho PF06087.12 EDO17562.1 - 8.3e-102 341.2 3.1 9.9e-102 341.0 3.1 1.1 1 0 0 1 1 1 1 Tyrosyl-DNA phosphodiesterase AMP-binding PF00501.28 EDO17563.1 - 9.2e-72 241.9 0.0 1.2e-71 241.6 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EDO17563.1 - 2.1e-16 60.7 0.1 1.6e-15 57.8 0.0 2.4 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain Transket_pyr PF02779.24 EDO17564.1 - 1.6e-47 161.5 0.0 3.3e-47 160.4 0.0 1.5 2 0 0 2 2 2 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 EDO17564.1 - 3.6e-38 130.2 0.0 6.8e-38 129.3 0.0 1.5 1 0 0 1 1 1 1 Transketolase, C-terminal domain RRG8 PF17068.5 EDO17564.1 - 0.14 11.5 0.1 0.25 10.7 0.1 1.3 1 0 0 1 1 1 0 Required for respiratory growth protein 8 mitochondrial CPSase_L_D2 PF02786.17 EDO17566.1 - 5.2e-83 277.7 0.4 9.1e-83 276.9 0.4 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain PYC_OADA PF02436.18 EDO17566.1 - 3.8e-67 225.9 0.0 6.2e-67 225.2 0.0 1.4 1 0 0 1 1 1 1 Conserved carboxylase domain Biotin_carb_N PF00289.22 EDO17566.1 - 1.1e-36 125.7 0.0 2.7e-36 124.5 0.0 1.7 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 EDO17566.1 - 8.5e-32 109.5 0.0 1.6e-30 105.4 0.0 2.6 2 0 0 2 2 2 1 Biotin carboxylase C-terminal domain HMGL-like PF00682.19 EDO17566.1 - 6.4e-27 94.8 0.3 1.4e-26 93.6 0.3 1.5 1 0 0 1 1 1 1 HMGL-like Biotin_lipoyl PF00364.22 EDO17566.1 - 8.7e-19 67.1 3.0 8.7e-19 67.1 3.0 3.0 2 0 0 2 2 2 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.6 EDO17566.1 - 6.8e-09 35.4 2.7 0.00027 20.7 0.1 2.8 1 1 1 2 2 2 2 Biotin-lipoyl like ATP-grasp PF02222.22 EDO17566.1 - 1e-06 28.4 0.1 2.1e-06 27.4 0.1 1.4 1 0 0 1 1 1 1 ATP-grasp domain Dala_Dala_lig_C PF07478.13 EDO17566.1 - 4.6e-06 26.3 0.0 9e-06 25.4 0.0 1.4 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp_3 PF02655.14 EDO17566.1 - 2e-05 24.7 0.0 4.4e-05 23.6 0.0 1.6 1 0 0 1 1 1 1 ATP-grasp domain RimK PF08443.11 EDO17566.1 - 0.00052 19.7 0.0 0.0015 18.2 0.0 1.8 1 1 0 1 1 1 1 RimK-like ATP-grasp domain HlyD_D23 PF16576.5 EDO17566.1 - 0.0013 18.0 1.0 0.029 13.6 0.2 2.8 2 1 1 3 3 3 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion ATPgrasp_ST PF14397.6 EDO17566.1 - 0.0017 17.7 0.0 0.0035 16.6 0.0 1.5 1 0 0 1 1 1 1 Sugar-transfer associated ATP-grasp HlyD_3 PF13437.6 EDO17566.1 - 0.025 15.3 1.3 0.55 11.0 0.3 3.5 3 1 1 4 4 3 0 HlyD family secretion protein RnfC_N PF13375.6 EDO17566.1 - 0.92 9.5 4.2 2.3 8.2 1.3 2.9 3 1 1 4 4 3 0 RnfC Barrel sandwich hybrid domain APG12 PF04110.13 EDO17567.1 - 8.8e-32 109.4 0.2 1.3e-31 108.8 0.2 1.3 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 Mst1_SARAH PF11629.8 EDO17567.1 - 0.07 13.2 0.1 0.17 12.0 0.1 1.6 1 0 0 1 1 1 0 C terminal SARAH domain of Mst1 Kinetochor_Ybp2 PF08568.10 EDO17568.1 - 9.2e-167 556.3 21.4 1e-166 556.1 21.4 1.0 1 0 0 1 1 1 1 Uncharacterised protein family, YAP/Alf4/glomulin HTH_19 PF12844.7 EDO17568.1 - 0.0099 15.9 0.2 0.043 13.8 0.2 2.2 1 0 0 1 1 1 1 Helix-turn-helix domain HUN PF08729.10 EDO17569.1 - 1.1e-07 31.7 0.1 1.1e-07 31.7 0.1 2.6 1 1 1 2 2 2 1 HPC2 and ubinuclein domain PP2C PF00481.21 EDO17570.1 - 2e-51 175.1 0.1 3.5e-51 174.3 0.1 1.4 1 0 0 1 1 1 1 Protein phosphatase 2C LRR_8 PF13855.6 EDO17570.1 - 1e-42 143.7 74.0 1.9e-09 37.2 4.6 9.8 5 3 4 9 9 9 8 Leucine rich repeat LRR_4 PF12799.7 EDO17570.1 - 1.7e-32 110.9 102.0 1.3e-06 28.6 5.9 13.6 9 2 4 14 14 13 10 Leucine Rich repeats (2 copies) Guanylate_cyc PF00211.20 EDO17570.1 - 1.6e-27 96.3 0.0 3.7e-27 95.1 0.0 1.5 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain LRR_9 PF14580.6 EDO17570.1 - 3e-06 26.8 30.4 0.00046 19.7 6.3 4.6 2 1 2 4 4 4 3 Leucine-rich repeat LRR_1 PF00560.33 EDO17570.1 - 6.1e-05 23.0 62.2 0.78 10.5 0.7 16.5 14 4 1 15 15 15 3 Leucine Rich Repeat LRR_5 PF13306.6 EDO17570.1 - 0.0001 22.3 21.0 0.00011 22.2 0.3 4.0 3 1 0 3 3 3 2 BspA type Leucine rich repeat region (6 copies) Ad_cyc_g-alpha PF08509.11 EDO17570.1 - 0.00054 19.6 0.1 0.0018 18.0 0.1 1.9 1 0 0 1 1 1 1 Adenylate cyclase G-alpha binding domain PP2C_2 PF13672.6 EDO17570.1 - 0.03 13.9 0.0 0.062 12.9 0.0 1.4 1 0 0 1 1 1 0 Protein phosphatase 2C LRR_6 PF13516.6 EDO17570.1 - 0.16 12.1 57.8 2.1 8.6 0.3 14.2 16 0 0 16 16 16 0 Leucine Rich repeat LRR_2 PF07723.13 EDO17570.1 - 0.3 11.8 4.3 56 4.6 0.2 4.7 4 1 1 5 5 5 0 Leucine Rich Repeat SYS1 PF09801.9 EDO17571.1 - 1.5e-50 171.1 12.3 1.8e-50 170.8 12.3 1.1 1 0 0 1 1 1 1 Integral membrane protein S linking to the trans Golgi network DEAD PF00270.29 EDO17572.1 - 1.8e-47 161.4 0.3 3.8e-47 160.3 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDO17572.1 - 6.1e-30 103.8 0.3 1.4e-28 99.5 0.0 3.3 4 0 0 4 4 4 1 Helicase conserved C-terminal domain BSP_II PF05432.11 EDO17572.1 - 0.0012 18.6 32.1 0.0012 18.6 32.1 2.3 2 0 0 2 2 2 1 Bone sialoprotein II (BSP-II) AAA_22 PF13401.6 EDO17572.1 - 0.14 12.4 0.5 0.42 10.9 0.0 2.0 2 0 0 2 2 2 0 AAA domain COX16 PF14138.6 EDO17573.1 - 6.7e-30 103.4 0.2 6.7e-30 103.4 0.2 1.4 2 0 0 2 2 2 1 Cytochrome c oxidase assembly protein COX16 MFS_1 PF07690.16 EDO17573.1 - 0.063 12.2 0.0 0.077 11.9 0.0 1.0 1 0 0 1 1 1 0 Major Facilitator Superfamily ORC_WH_C PF18137.1 EDO17574.1 - 9.7e-21 74.3 0.2 9.7e-21 74.3 0.2 2.1 2 1 0 2 2 2 1 Origin recognition complex winged helix C-terminal Proteasome PF00227.26 EDO17575.1 - 6.3e-49 166.0 0.9 7.2e-49 165.9 0.9 1.0 1 0 0 1 1 1 1 Proteasome subunit HAT_KAT11 PF08214.11 EDO17576.1 - 5.7e-111 371.2 3.1 6.7e-111 371.0 3.1 1.0 1 0 0 1 1 1 1 Histone acetylation protein Ribosomal_L34 PF00468.17 EDO17576.1 - 0.088 12.8 0.7 0.2 11.6 0.7 1.5 1 0 0 1 1 1 0 Ribosomal protein L34 Fasciclin PF02469.22 EDO17577.1 - 5.4e-18 65.4 10.8 3.9e-05 23.9 1.1 6.7 5 3 0 5 5 5 5 Fasciclin domain Rax2 PF12768.7 EDO17577.1 - 0.0064 16.0 1.2 0.058 12.8 0.0 2.9 3 0 0 3 3 3 1 Cortical protein marker for cell polarity Aa_trans PF01490.18 EDO17578.1 - 4.9e-82 275.8 25.6 6e-82 275.5 25.6 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Ribosomal_S17_N PF16205.5 EDO17580.1 - 1.1e-32 112.2 1.0 2.4e-32 111.1 1.0 1.6 1 0 0 1 1 1 1 Ribosomal_S17 N-terminal Ribosomal_S17 PF00366.20 EDO17580.1 - 4.5e-27 93.9 3.0 4.5e-27 93.9 3.0 1.7 2 0 0 2 2 2 1 Ribosomal protein S17 Myb_DNA-binding PF00249.31 EDO17581.1 - 2.1e-18 66.2 22.1 5.9e-11 42.4 0.7 4.2 3 1 0 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EDO17581.1 - 8.6e-16 57.9 15.3 1.1e-13 51.2 1.8 3.5 3 0 0 3 3 3 2 Myb-like DNA-binding domain Microtub_bd PF16796.5 EDO17581.1 - 0.0003 20.7 0.5 0.0003 20.7 0.5 2.4 2 1 1 3 3 3 1 Microtubule binding Trp_oprn_chp PF09534.10 EDO17581.1 - 0.067 13.0 0.1 0.23 11.2 0.1 1.9 1 0 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Myb_DNA-bind_4 PF13837.6 EDO17581.1 - 8.8 6.8 24.7 0.21 12.0 10.7 4.3 4 2 0 4 4 4 0 Myb/SANT-like DNA-binding domain Vps54 PF07928.12 EDO17582.1 - 2.9 8.3 7.4 3.7 8.0 2.0 3.3 2 1 0 2 2 2 0 Vps54-like protein DUF1752 PF08550.10 EDO17583.1 - 1.6e-12 47.0 3.0 3.4e-12 46.0 3.0 1.6 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) DUF5428 PF17493.2 EDO17583.1 - 0.038 14.4 0.0 0.54 10.7 0.0 2.8 3 0 0 3 3 3 0 Family of unknown function (DUF5428) WD40 PF00400.32 EDO17584.1 - 8.1e-13 48.6 1.1 0.0043 17.9 0.1 4.9 5 0 0 5 5 5 4 WD domain, G-beta repeat CX9C PF16860.5 EDO17585.1 - 4e-26 90.7 12.3 4.1e-17 61.9 3.1 2.1 2 0 0 2 2 2 2 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, CHCH PF06747.13 EDO17585.1 - 1.6e-09 37.6 8.1 4.1e-05 23.6 1.2 2.2 2 0 0 2 2 2 2 CHCH domain UPF0203 PF05254.12 EDO17585.1 - 0.0001 22.5 7.4 0.012 15.8 1.0 3.5 1 1 2 3 3 3 2 Uncharacterised protein family (UPF0203) Cmc1 PF08583.10 EDO17585.1 - 0.00012 22.1 9.1 0.0078 16.2 1.9 2.2 1 1 1 2 2 2 2 Cytochrome c oxidase biogenesis protein Cmc1 like GCK PF07802.11 EDO17585.1 - 0.0015 18.9 4.6 0.2 12.1 0.1 2.3 1 1 2 3 3 3 3 GCK domain COX6B PF02297.17 EDO17585.1 - 0.027 14.7 7.8 0.1 12.8 4.7 2.1 1 1 1 2 2 2 0 Cytochrome oxidase c subunit VIb NDUF_B7 PF05676.13 EDO17585.1 - 0.038 13.7 7.6 0.75 9.6 0.6 3.2 1 1 2 3 3 3 0 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) Pet191_N PF10203.9 EDO17585.1 - 0.044 14.1 10.8 0.77 10.1 6.1 3.0 1 1 1 2 2 2 0 Cytochrome c oxidase assembly protein PET191 DB PF01682.19 EDO17585.1 - 0.18 12.1 9.0 4.6 7.6 9.0 2.1 1 1 1 2 2 2 0 DB module UCR_hinge PF02320.16 EDO17585.1 - 0.33 11.2 7.3 19 5.6 0.1 3.2 1 1 1 2 2 2 0 Ubiquinol-cytochrome C reductase hinge protein COX17 PF05051.13 EDO17585.1 - 0.48 10.8 8.0 7.7 7.0 1.8 3.3 1 1 3 4 4 4 0 Cytochrome C oxidase copper chaperone (COX17) FMN_red PF03358.15 EDO17586.1 - 9.5e-13 48.2 0.0 1.3e-12 47.7 0.0 1.1 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 EDO17586.1 - 2.4e-05 24.2 0.0 3.1e-05 23.8 0.0 1.2 1 0 0 1 1 1 1 Flavodoxin-like fold Flavodoxin_5 PF12724.7 EDO17586.1 - 0.021 15.0 0.0 0.03 14.6 0.0 1.2 1 0 0 1 1 1 0 Flavodoxin domain SGL PF08450.12 EDO17587.1 - 1.4e-44 152.6 0.2 2e-44 152.0 0.2 1.2 1 0 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region Coatomer_WDAD PF04053.14 EDO17587.1 - 0.017 14.2 0.4 0.074 12.1 0.2 1.8 1 1 0 2 2 2 0 Coatomer WD associated region PQQ PF01011.21 EDO17587.1 - 0.025 14.5 0.1 0.23 11.5 0.0 2.7 2 0 0 2 2 2 0 PQQ enzyme repeat MRJP PF03022.16 EDO17587.1 - 0.06 12.7 0.1 1 8.7 0.0 2.2 2 0 0 2 2 2 0 Major royal jelly protein Bac_rhodopsin PF01036.18 EDO17588.1 - 1.7e-44 152.0 18.4 2.1e-44 151.8 18.4 1.0 1 0 0 1 1 1 1 Bacteriorhodopsin-like protein DUF1772 PF08592.11 EDO17588.1 - 0.31 11.3 7.8 0.77 10.1 0.2 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF1772) Fungal_trans_2 PF11951.8 EDO17589.1 - 2.6e-21 75.9 1.4 5.6e-21 74.8 1.4 1.5 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDO17589.1 - 4.1e-06 26.8 12.7 4.1e-06 26.8 12.7 1.9 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain hnRNP_Q_AcD PF18360.1 EDO17589.1 - 0.13 12.2 0.3 5.6 7.0 0.0 2.7 2 0 0 2 2 2 0 Heterogeneous nuclear ribonucleoprotein Q acidic domain PRP1_N PF06424.12 EDO17590.1 - 1.6e-22 80.5 15.6 3.2e-21 76.3 10.6 2.8 2 1 0 2 2 2 1 PRP1 splicing factor, N-terminal TPR_19 PF14559.6 EDO17590.1 - 3e-17 62.9 0.0 0.017 15.6 0.0 6.7 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_14 PF13428.6 EDO17590.1 - 8.3e-14 51.1 0.2 1.4 9.9 0.0 8.3 6 2 2 8 8 8 3 Tetratricopeptide repeat TPR_16 PF13432.6 EDO17590.1 - 1.2e-07 32.2 0.0 0.19 12.4 0.0 4.7 5 0 0 5 5 5 2 Tetratricopeptide repeat ChAPs PF09295.10 EDO17590.1 - 1.4e-07 30.9 7.6 0.00065 18.8 1.6 3.2 3 0 0 3 3 3 2 ChAPs (Chs5p-Arf1p-binding proteins) ANAPC3 PF12895.7 EDO17590.1 - 0.00032 20.9 0.8 0.0022 18.2 0.0 2.7 3 0 0 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 EDO17590.1 - 0.00084 19.4 1.4 0.14 12.4 0.0 4.4 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_17 PF13431.6 EDO17590.1 - 0.001 19.3 4.4 7 7.3 0.0 5.8 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_2 PF07719.17 EDO17590.1 - 0.0017 18.3 0.9 45 4.5 0.0 6.0 7 0 0 7 7 7 0 Tetratricopeptide repeat NARP1 PF12569.8 EDO17590.1 - 0.0038 16.2 0.1 0.71 8.7 0.0 3.3 2 1 0 3 3 3 1 NMDA receptor-regulated protein 1 Suf PF05843.14 EDO17590.1 - 0.012 15.6 1.3 0.012 15.6 1.3 3.1 5 0 0 5 5 5 0 Suppressor of forked protein (Suf) Blt1 PF12754.7 EDO17590.1 - 0.04 14.2 2.3 4.9 7.5 0.1 2.4 2 0 0 2 2 2 0 Blt1 N-terminal domain Cellulase PF00150.18 EDO17591.1 - 5.8e-10 39.1 4.6 1e-09 38.3 4.6 1.3 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) RNaseH_like PF04308.12 EDO17592.1 - 4.1 7.3 8.4 0.43 10.5 1.6 2.5 2 1 1 3 3 3 0 Ribonuclease H-like PIP5K PF01504.18 EDO17594.1 - 4.2e-88 295.1 5.0 4.2e-88 295.1 5.0 2.1 2 1 1 3 3 3 1 Phosphatidylinositol-4-phosphate 5-Kinase Pre-PUA PF17832.1 EDO17594.1 - 0.28 11.9 3.4 1.7 9.4 1.3 3.0 3 0 0 3 3 3 0 Pre-PUA-like domain TBCA PF02970.16 EDO17594.1 - 4.1 7.8 6.9 1.2 9.5 3.4 1.9 2 0 0 2 2 2 0 Tubulin binding cofactor A Zn_clus PF00172.18 EDO17595.1 - 7.7e-09 35.5 9.3 1.7e-08 34.4 9.3 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Transp_cyt_pur PF02133.15 EDO17596.1 - 7.8e-73 245.7 40.1 1e-72 245.3 40.1 1.1 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Clat_adaptor_s PF01217.20 EDO17597.1 - 5.3e-56 188.5 4.6 6.1e-56 188.3 4.6 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain MRG PF05712.13 EDO17597.1 - 0.1 11.9 0.1 0.11 11.8 0.1 1.2 1 0 0 1 1 1 0 MRG TP_methylase PF00590.20 EDO17598.1 - 2.4e-25 89.7 0.0 3.5e-25 89.2 0.0 1.2 1 0 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases DUF4434 PF14488.6 EDO17598.1 - 0.14 12.1 0.0 0.28 11.2 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4434) ABC1 PF03109.16 EDO17600.1 - 3e-33 114.5 0.0 5.4e-33 113.7 0.0 1.4 1 0 0 1 1 1 1 ABC1 family RIO1 PF01163.22 EDO17600.1 - 6e-05 22.7 0.1 0.0011 18.6 0.0 2.7 3 0 0 3 3 3 1 RIO1 family Pkinase PF00069.25 EDO17600.1 - 0.041 13.2 0.0 0.19 11.1 0.0 1.9 2 0 0 2 2 2 0 Protein kinase domain OCD_Mu_crystall PF02423.15 EDO17601.1 - 3.3e-09 36.1 0.0 0.0013 17.7 0.0 2.1 2 0 0 2 2 2 2 Ornithine cyclodeaminase/mu-crystallin family Zn_clus PF00172.18 EDO17602.1 - 2.9e-08 33.7 8.6 6.1e-08 32.7 8.6 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EDO17602.1 - 6.4e-06 25.4 2.4 1.7e-05 24.0 2.4 1.8 1 0 0 1 1 1 1 Fungal specific transcription factor domain Pirin PF02678.16 EDO17603.1 - 1.5e-27 95.7 0.1 6.8e-26 90.4 0.1 2.2 2 0 0 2 2 2 1 Pirin Pirin_C PF05726.13 EDO17603.1 - 3.2e-15 56.3 0.0 1.5e-14 54.2 0.0 1.9 2 0 0 2 2 2 1 Pirin C-terminal cupin domain Cupin_2 PF07883.11 EDO17603.1 - 4e-06 26.5 1.3 1.9e-05 24.3 0.5 2.1 2 0 0 2 2 2 1 Cupin domain E1-E2_ATPase PF00122.20 EDO17605.1 - 1.5e-18 66.9 0.0 3.3e-18 65.9 0.0 1.6 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.26 EDO17605.1 - 3.1e-17 63.5 0.0 3.3e-09 37.4 0.0 2.4 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EDO17605.1 - 9.3e-07 28.9 0.0 2.8e-06 27.3 0.0 1.8 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 EDO17605.1 - 0.0032 17.2 3.0 0.0081 15.9 0.4 2.8 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 EDO17605.1 - 0.15 11.5 0.0 0.3 10.6 0.0 1.4 1 0 0 1 1 1 0 Sucrose-6F-phosphate phosphohydrolase HSP70 PF00012.20 EDO17606.1 - 6.1e-267 886.7 15.5 7e-267 886.5 15.5 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EDO17606.1 - 5.2e-15 55.1 4.2 3.6e-13 49.0 1.3 2.4 2 0 0 2 2 2 2 MreB/Mbl protein FGGY_C PF02782.16 EDO17606.1 - 0.00058 19.6 0.0 0.0019 18.0 0.0 1.9 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain DUF5321 PF17254.2 EDO17606.1 - 0.0079 15.6 0.9 0.0079 15.6 0.9 2.7 2 1 1 3 3 3 1 Family of unknown function (DUF5321) Syntaxin_2 PF14523.6 EDO17606.1 - 0.34 11.3 6.9 1.8 9.0 6.9 2.2 1 1 0 1 1 1 0 Syntaxin-like protein FtsA PF14450.6 EDO17606.1 - 0.5 10.8 11.4 1.5 9.2 0.9 4.1 3 2 0 3 3 3 0 Cell division protein FtsA YlbD_coat PF14071.6 EDO17606.1 - 0.53 10.5 5.6 0.86 9.9 4.6 1.8 1 1 0 1 1 1 0 Putative coat protein DUF16 PF01519.16 EDO17606.1 - 1.4 9.5 7.2 4.2 7.9 7.2 1.9 1 0 0 1 1 1 0 Protein of unknown function DUF16 Raco_middle PF17651.1 EDO17606.1 - 9 5.9 7.6 40 3.8 0.0 3.7 4 0 0 4 4 4 0 RACo middle region Vps55 PF04133.14 EDO17607.1 - 3e-42 143.3 8.0 3.5e-42 143.1 8.0 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting 55 DUF1269 PF06897.12 EDO17608.1 - 0.15 12.3 0.2 0.37 11.1 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1269) EMP24_GP25L PF01105.24 EDO17609.1 - 9.9e-51 172.3 0.8 1.1e-50 172.1 0.8 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD WD40 PF00400.32 EDO17610.1 - 8e-11 42.3 3.9 7.1e-05 23.5 0.6 5.1 5 0 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDO17610.1 - 7.5e-06 26.2 0.4 0.01 16.1 0.0 4.2 1 1 3 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EDO17610.1 - 3.6e-05 23.7 2.8 0.0022 17.9 0.0 3.2 3 1 0 3 3 3 1 Eukaryotic translation initiation factor eIF2A Cytochrom_D1 PF02239.16 EDO17610.1 - 0.034 12.7 0.0 0.12 10.9 0.0 1.8 1 1 0 1 1 1 0 Cytochrome D1 heme domain WD40 PF00400.32 EDO17611.1 - 8e-20 70.8 8.3 0.00027 21.7 0.3 5.8 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDO17611.1 - 1.6e-14 53.9 5.2 1.6e-08 34.7 0.1 3.7 3 1 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EDO17611.1 - 4.3e-06 26.7 0.3 0.0017 18.3 0.1 3.0 2 1 1 3 3 3 3 Eukaryotic translation initiation factor eIF2A Zn_clus PF00172.18 EDO17612.1 - 1.2e-05 25.3 6.4 1.2e-05 25.3 6.4 1.6 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EDO17612.1 - 3.7e-05 22.9 1.7 8.6e-05 21.7 1.7 1.7 1 0 0 1 1 1 1 Fungal specific transcription factor domain COG5 PF10392.9 EDO17613.1 - 0.0012 19.0 2.6 0.11 12.7 0.1 3.2 2 1 1 3 3 3 1 Golgi transport complex subunit 5 CENP-F_leu_zip PF10473.9 EDO17613.1 - 0.0021 18.1 0.2 0.006 16.6 0.0 1.7 2 0 0 2 2 2 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 CompInhib_SCIN PF11546.8 EDO17613.1 - 0.058 13.4 1.6 7.6 6.6 0.1 2.6 2 1 0 2 2 2 0 Staphylococcal complement inhibitor SCIN BLOC1_2 PF10046.9 EDO17613.1 - 0.34 11.2 3.3 1.7 9.0 0.1 3.3 3 1 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 ING PF12998.7 EDO17613.1 - 1.1 9.9 5.6 96 3.6 4.5 3.1 2 1 0 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding Cation_ATPase_C PF00689.21 EDO17614.1 - 2.4e-42 144.7 7.8 2.4e-42 144.7 7.8 2.9 4 0 0 4 4 4 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 EDO17614.1 - 4.9e-33 114.2 0.7 4.9e-33 114.2 0.7 4.0 4 1 0 4 4 4 1 E1-E2 ATPase Cation_ATPase PF13246.6 EDO17614.1 - 2e-21 75.8 0.0 4.2e-21 74.8 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 EDO17614.1 - 3e-16 60.4 0.0 2.3e-12 47.7 0.0 2.9 3 0 0 3 3 3 2 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EDO17614.1 - 2.6e-14 52.7 0.0 7.9e-14 51.1 0.0 1.9 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 EDO17614.1 - 0.00018 21.3 0.3 0.0027 17.5 0.3 2.6 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Glucos_trans_II PF14264.6 EDO17614.1 - 0.53 9.6 8.8 1.3 8.3 3.6 2.9 2 0 0 2 2 2 0 Glucosyl transferase GtrII DUF2207 PF09972.9 EDO17614.1 - 1.6 7.4 7.0 0.52 9.0 0.5 2.8 3 0 0 3 3 3 0 Predicted membrane protein (DUF2207) tRNA_int_endo PF01974.17 EDO17615.1 - 1.3e-09 38.0 0.0 2.7e-09 36.9 0.0 1.5 1 0 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain UPF0730 PF15827.5 EDO17615.1 - 0.15 11.8 0.7 0.39 10.5 0.7 1.7 1 0 0 1 1 1 0 UPF0730 unknown protein family PUF PF00806.19 EDO17616.1 - 1.7e-65 213.2 9.8 2.4e-09 36.4 0.2 8.5 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat CPL PF08144.11 EDO17616.1 - 0.019 15.3 0.9 9.4 6.6 0.1 3.8 1 1 2 4 4 4 0 CPL (NUC119) domain LIDHydrolase PF10230.9 EDO17616.1 - 0.086 12.4 0.0 0.15 11.5 0.0 1.3 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase SopA PF13981.6 EDO17616.1 - 0.13 12.7 0.0 0.43 11.0 0.0 1.8 1 0 0 1 1 1 0 SopA-like central domain Fungal_trans PF04082.18 EDO17617.1 - 2.1e-22 79.5 10.1 2.1e-22 79.5 10.1 2.6 3 0 0 3 3 3 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDO17617.1 - 1.4e-07 31.5 11.1 3.2e-07 30.4 11.1 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF2313 PF10076.9 EDO17617.1 - 0.21 11.5 1.2 2.7 7.8 0.1 3.0 2 2 0 3 3 3 0 Uncharacterised protein conserved in bacteria (DUF2313) ERG4_ERG24 PF01222.17 EDO17618.1 - 2.2e-176 586.9 30.5 2.5e-176 586.7 30.5 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family Rsc14 PF08586.10 EDO17619.1 - 1.8e-41 141.0 2.4 1.9e-41 140.9 0.7 1.7 2 0 0 2 2 2 1 RSC complex, Rsc14/Ldb7 subunit Proteasome PF00227.26 EDO17620.1 - 4e-42 143.9 0.0 6.6e-42 143.1 0.0 1.3 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EDO17620.1 - 1.9e-15 56.2 0.1 3.9e-15 55.2 0.1 1.5 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature DUF962 PF06127.11 EDO17621.1 - 2.5e-24 85.2 5.1 8e-24 83.6 5.1 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF962) SfLAP PF11139.8 EDO17622.1 - 0.015 14.8 0.0 0.024 14.1 0.0 1.2 1 0 0 1 1 1 0 Sap, sulfolipid-1-addressing protein OGG_N PF07934.12 EDO17622.1 - 5.7 7.1 7.9 5.6 7.1 2.8 2.3 2 0 0 2 2 2 0 8-oxoguanine DNA glycosylase, N-terminal domain PMP1_2 PF08114.11 EDO17623.1 - 2.8e-26 91.0 4.6 3e-26 90.9 4.6 1.0 1 0 0 1 1 1 1 ATPase proteolipid family RELT PF12606.8 EDO17623.1 - 0.017 14.1 0.7 0.02 13.9 0.7 1.2 1 0 0 1 1 1 0 Tumour necrosis factor receptor superfamily member 19 LapA_dom PF06305.11 EDO17623.1 - 0.19 11.6 1.4 0.21 11.4 1.4 1.0 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain TPP_enzyme_N PF02776.18 EDO17624.1 - 8.2e-34 116.7 0.0 1.4e-33 116.0 0.0 1.4 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.22 EDO17624.1 - 6.2e-22 77.8 0.0 1.2e-21 76.9 0.0 1.4 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.21 EDO17624.1 - 6.3e-22 78.0 0.0 4.6e-21 75.2 0.0 2.3 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain DUF4940 PF16298.5 EDO17624.1 - 0.027 14.2 0.2 0.21 11.2 0.2 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4940) DUF1863 PF08937.11 EDO17624.1 - 0.047 14.0 1.8 2.7 8.3 0.7 3.0 3 0 0 3 3 3 0 MTH538 TIR-like domain (DUF1863) 14-3-3 PF00244.20 EDO17625.1 - 3.1e-105 350.6 4.7 3.6e-105 350.4 4.7 1.0 1 0 0 1 1 1 1 14-3-3 protein FlaF PF07309.11 EDO17625.1 - 0.0092 16.0 0.2 0.021 14.8 0.2 1.6 1 0 0 1 1 1 1 Flagellar protein FlaF FRG PF08867.11 EDO17625.1 - 0.089 13.8 0.3 0.31 12.0 0.2 2.0 1 1 1 2 2 2 0 FRG domain COPI_assoc PF08507.10 EDO17626.1 - 1.9e-41 141.1 10.9 2.2e-41 141.0 10.9 1.0 1 0 0 1 1 1 1 COPI associated protein Peptidase_M24 PF00557.24 EDO17627.1 - 9.7e-07 28.7 0.0 1.9e-06 27.8 0.0 1.5 1 0 0 1 1 1 1 Metallopeptidase family M24 TEA PF01285.18 EDO17627.1 - 0.11 12.6 0.0 0.26 11.4 0.0 1.6 1 0 0 1 1 1 0 TEA/ATTS domain Ste5_C PF12194.8 EDO17628.1 - 1.7e-83 279.2 0.1 3.7e-83 278.2 0.1 1.5 1 0 0 1 1 1 1 Protein kinase Fus3-binding zf-RING_2 PF13639.6 EDO17628.1 - 0.00059 20.1 4.4 0.0013 19.0 4.4 1.7 1 0 0 1 1 1 1 Ring finger domain Zn_ribbon_17 PF17120.5 EDO17628.1 - 0.00093 18.8 1.4 0.0021 17.7 1.4 1.6 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-RING_UBOX PF13445.6 EDO17628.1 - 0.0021 18.0 0.5 0.0054 16.7 0.5 1.7 1 0 0 1 1 1 1 RING-type zinc-finger PH_10 PF15411.6 EDO17628.1 - 0.0033 17.7 0.0 0.0033 17.7 0.0 2.7 3 0 0 3 3 3 1 Pleckstrin homology domain zf-C3HC4_2 PF13923.6 EDO17628.1 - 0.0054 16.6 0.4 0.015 15.1 0.4 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EDO17628.1 - 0.017 14.9 1.1 0.037 13.8 1.1 1.6 1 0 0 1 1 1 0 RING-like zinc finger PHD PF00628.29 EDO17628.1 - 0.047 13.6 2.8 0.13 12.2 2.8 1.8 1 0 0 1 1 1 0 PHD-finger zf-RING_5 PF14634.6 EDO17628.1 - 0.24 11.4 4.8 0.58 10.2 4.8 1.7 1 1 0 1 1 1 0 zinc-RING finger domain zf-C3HC4 PF00097.25 EDO17628.1 - 0.54 10.2 3.5 0.82 9.6 2.7 1.8 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Candida_ALS_N PF11766.8 EDO17629.1 - 3e-66 223.2 4.7 6.1e-66 222.2 4.7 1.5 1 0 0 1 1 1 1 Cell-wall agglutinin N-terminal ligand-sugar binding Flocculin PF00624.18 EDO17629.1 - 8.8e-17 61.1 63.4 8.1e-09 35.6 24.7 3.4 3 0 0 3 3 3 2 Flocculin repeat Ssl1 PF04056.14 EDO17630.1 - 7.5e-87 290.1 0.0 1.1e-86 289.6 0.0 1.2 1 0 0 1 1 1 1 Ssl1-like C1_4 PF07975.12 EDO17630.1 - 1.5e-25 89.1 10.0 1.5e-25 89.1 10.0 2.8 2 0 0 2 2 2 1 TFIIH C1-like domain VWA_2 PF13519.6 EDO17630.1 - 9.9e-15 55.1 0.0 2.4e-14 53.9 0.0 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 EDO17630.1 - 1.6e-05 25.2 0.0 2.9e-05 24.4 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain IBR PF01485.21 EDO17630.1 - 0.015 15.5 6.3 0.015 15.5 6.3 2.9 2 0 0 2 2 2 0 IBR domain, a half RING-finger domain zf-HIT PF04438.16 EDO17630.1 - 1.4 8.8 20.5 0.56 10.1 6.1 3.4 3 0 0 3 3 3 0 HIT zinc finger PTPRCAP PF15713.5 EDO17630.1 - 1.6 9.0 6.1 2.4 8.4 6.1 1.2 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated DZR PF12773.7 EDO17630.1 - 6.6 6.8 22.0 1.4 9.0 6.9 3.4 2 1 0 2 2 2 0 Double zinc ribbon MFS_1 PF07690.16 EDO17631.1 - 2e-27 96.1 22.5 4.9e-27 94.8 22.0 1.7 1 1 1 2 2 2 1 Major Facilitator Superfamily Response_reg PF00072.24 EDO17632.1 - 1.3e-20 73.6 0.0 1.1e-13 51.3 0.0 2.5 1 1 1 2 2 2 2 Response regulator receiver domain SMC_Nse1 PF07574.13 EDO17633.1 - 2.3e-54 184.2 0.0 3.2e-54 183.8 0.0 1.2 1 0 0 1 1 1 1 Nse1 non-SMC component of SMC5-6 complex zf-RING-like PF08746.11 EDO17633.1 - 2.9e-13 49.9 13.2 5.9e-13 48.9 13.2 1.5 1 0 0 1 1 1 1 RING-like domain XPA_N PF01286.18 EDO17633.1 - 0.37 10.9 3.6 0.54 10.3 0.0 2.8 3 0 0 3 3 3 0 XPA protein N-terminal Pam16 PF03656.13 EDO17634.1 - 1.4e-05 25.1 0.0 1.9e-05 24.7 0.0 1.3 1 0 0 1 1 1 1 Pam16 DnaJ PF00226.31 EDO17634.1 - 0.0017 18.4 0.1 0.003 17.7 0.1 1.4 1 0 0 1 1 1 1 DnaJ domain Proteasome PF00227.26 EDO17634.1 - 0.098 12.1 0.1 0.18 11.3 0.0 1.4 1 1 0 1 1 1 0 Proteasome subunit Ribosomal_L24e PF01246.20 EDO17635.1 - 1.1e-32 112.0 3.7 1.1e-32 112.0 3.7 1.9 2 0 0 2 2 2 1 Ribosomal protein L24e TFIIF_alpha PF05793.12 EDO17635.1 - 0.75 8.3 17.1 1 7.9 17.1 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Na_trans_assoc PF06512.13 EDO17635.1 - 0.94 9.7 9.6 1.5 9.1 9.6 1.3 1 1 0 1 1 1 0 Sodium ion transport-associated Ten1 PF12658.7 EDO17636.1 - 8.5e-21 74.1 0.0 1e-20 73.9 0.0 1.1 1 0 0 1 1 1 1 Telomere capping, CST complex subunit Peripla_BP_1 PF00532.21 EDO17637.1 - 0.15 11.4 0.0 0.24 10.8 0.0 1.2 1 0 0 1 1 1 0 Periplasmic binding proteins and sugar binding domain of LacI family Secretin_N_2 PF07655.13 EDO17637.1 - 9.4 6.9 14.4 1.7 9.2 6.1 2.6 3 0 0 3 3 3 0 Secretin N-terminal domain HSP70 PF00012.20 EDO17638.1 - 2.9e-263 874.5 12.6 3.3e-263 874.3 12.6 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EDO17638.1 - 1.1e-18 67.1 1.8 2.5e-17 62.7 0.4 2.2 2 0 0 2 2 2 1 MreB/Mbl protein FtsA PF14450.6 EDO17638.1 - 0.0011 19.4 3.6 1.1 9.7 0.1 3.6 3 2 0 3 3 3 2 Cell division protein FtsA BcrAD_BadFG PF01869.20 EDO17638.1 - 0.011 15.3 0.5 0.13 11.7 0.5 2.2 1 1 0 1 1 1 0 BadF/BadG/BcrA/BcrD ATPase family Hydantoinase_A PF01968.18 EDO17638.1 - 0.016 14.5 2.1 0.64 9.2 0.0 3.2 2 1 0 3 3 3 0 Hydantoinase/oxoprolinase Radial_spoke_3 PF06098.11 EDO17638.1 - 0.066 12.5 0.5 0.12 11.6 0.5 1.4 1 0 0 1 1 1 0 Radial spoke protein 3 Kri1 PF05178.12 EDO17638.1 - 0.15 12.7 13.8 0.026 15.1 8.8 2.3 2 0 0 2 2 2 0 KRI1-like family Spore_GerAC PF05504.11 EDO17638.1 - 0.29 11.3 0.1 0.29 11.3 0.1 3.4 4 0 0 4 4 4 0 Spore germination B3/ GerAC like, C-terminal DUF5300 PF17224.3 EDO17638.1 - 2.4 8.5 5.8 8 6.8 0.1 3.6 4 0 0 4 4 4 0 Domain of unknown function (DUF5300) FHA PF00498.26 EDO17639.1 - 2.1e-15 56.8 0.0 3.6e-15 56.1 0.0 1.5 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 EDO17639.1 - 0.0023 18.2 0.2 0.0059 16.9 0.1 1.6 2 0 0 2 2 2 1 Inner membrane component of T3SS, cytoplasmic domain DEAD PF00270.29 EDO17640.1 - 6.6e-46 156.3 0.1 2.9e-45 154.2 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDO17640.1 - 5.8e-26 91.0 0.0 1.8e-25 89.4 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 EDO17640.1 - 5e-20 71.5 0.0 1.1e-19 70.4 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 EDO17640.1 - 4.9e-06 26.6 0.0 4.9e-06 26.6 0.0 2.7 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit Vpu PF00558.19 EDO17640.1 - 0.41 10.5 2.0 1.5 8.6 2.0 1.9 1 0 0 1 1 1 0 Vpu protein ABC_tran_CTD PF16326.5 EDO17640.1 - 8.8 6.7 12.5 0.93 9.8 0.0 3.5 3 0 0 3 3 3 0 ABC transporter C-terminal domain Cyclin_N PF00134.23 EDO17641.1 - 7.3e-11 41.9 5.0 7.3e-11 41.9 5.0 1.9 2 1 1 3 3 3 1 Cyclin, N-terminal domain PPTA PF01239.22 EDO17642.1 - 7.6e-38 127.2 21.6 2.7e-08 33.3 0.2 6.6 6 0 0 6 6 6 5 Protein prenyltransferase alpha subunit repeat HORMA PF02301.18 EDO17643.1 - 5.9e-23 81.6 0.1 1.1e-22 80.6 0.1 1.4 1 1 0 1 1 1 1 HORMA domain bacHORMA_2 PF18173.1 EDO17643.1 - 0.011 15.6 0.3 0.035 14.0 0.0 1.8 2 1 0 2 2 2 0 Bacterial HORMA domain 2 ATG13 PF10033.9 EDO17643.1 - 0.025 14.3 0.0 0.036 13.8 0.0 1.3 1 0 0 1 1 1 0 Autophagy-related protein 13 DUF5415 PF17436.2 EDO17643.1 - 0.042 13.9 0.2 0.23 11.6 0.1 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5415) DUF2959 PF11172.8 EDO17643.1 - 0.066 13.4 0.1 0.096 12.8 0.1 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF2959) Vps53_N PF04100.12 EDO17644.1 - 9.6e-87 291.4 14.8 1.6e-86 290.6 14.8 1.4 1 0 0 1 1 1 1 Vps53-like, N-terminal VPS53_C PF16854.5 EDO17644.1 - 1.3e-82 276.6 9.9 3.3e-82 275.3 9.9 1.7 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 53 C-terminus Pkinase PF00069.25 EDO17645.1 - 1.6e-69 234.3 0.0 2.1e-69 233.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO17645.1 - 2.9e-36 125.1 0.0 4e-36 124.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase FHA PF00498.26 EDO17645.1 - 2.1e-16 60.0 0.6 6.1e-16 58.5 0.6 1.9 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 EDO17645.1 - 4.2e-07 30.2 0.0 1.2e-06 28.7 0.0 1.8 1 1 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain Pkinase_fungal PF17667.1 EDO17645.1 - 9.2e-05 21.4 0.0 0.00012 21.0 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EDO17645.1 - 0.00059 19.3 0.1 0.00088 18.7 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EDO17645.1 - 0.0067 15.8 0.3 2.6 7.3 0.0 2.9 3 0 0 3 3 3 2 Kinase-like DNA_pol_B PF00136.21 EDO17646.1 - 5.5e-143 477.0 0.9 7.5e-143 476.6 0.9 1.2 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 EDO17646.1 - 2.6e-86 289.8 0.8 5.4e-86 288.8 0.8 1.6 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.6 EDO17646.1 - 8.8e-18 64.5 6.6 8.8e-18 64.5 6.6 1.9 2 0 0 2 2 2 1 C4-type zinc-finger of DNA polymerase delta DNA_pol_B_2 PF03175.13 EDO17646.1 - 8.3e-06 24.9 0.4 0.00067 18.6 0.1 2.3 2 0 0 2 2 2 2 DNA polymerase type B, organellar and viral DNA_pol_B_exo2 PF10108.9 EDO17646.1 - 0.00047 19.9 0.0 0.00086 19.0 0.0 1.4 1 0 0 1 1 1 1 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB AMPKBI PF04739.15 EDO17647.1 - 1.4e-16 60.5 0.6 1.4e-16 60.5 0.6 2.7 2 0 0 2 2 2 1 5'-AMP-activated protein kinase beta subunit, interaction domain AMPK1_CBM PF16561.5 EDO17647.1 - 9.2e-09 35.4 2.0 1.7e-08 34.5 0.0 2.4 2 0 0 2 2 2 1 Glycogen recognition site of AMP-activated protein kinase PAP1 PF08601.10 EDO17648.1 - 1.2e-16 61.4 2.4 1.2e-16 61.4 2.4 3.9 1 1 1 3 3 3 1 Transcription factor PAP1 bZIP_1 PF00170.21 EDO17648.1 - 1.4e-05 25.0 15.2 1.4e-05 25.0 15.2 2.6 2 1 0 2 2 2 1 bZIP transcription factor ACCA PF03255.14 EDO17648.1 - 0.0039 17.1 3.0 0.012 15.5 3.0 1.8 1 0 0 1 1 1 1 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit bZIP_Maf PF03131.17 EDO17648.1 - 1.3 9.6 13.2 0.1 13.1 7.8 2.1 2 0 0 2 2 2 0 bZIP Maf transcription factor bZIP_2 PF07716.15 EDO17648.1 - 2.2 8.4 23.7 0.035 14.2 15.3 2.4 2 1 1 3 3 3 0 Basic region leucine zipper DUF16 PF01519.16 EDO17648.1 - 4.1 8.0 11.2 0.51 10.9 6.2 2.1 2 0 0 2 2 2 0 Protein of unknown function DUF16 Sterol_MT_C PF08498.10 EDO17649.1 - 1.1e-26 92.9 0.7 1.8e-26 92.2 0.7 1.3 1 0 0 1 1 1 1 Sterol methyltransferase C-terminal Methyltransf_11 PF08241.12 EDO17649.1 - 2.5e-18 66.5 0.0 5e-18 65.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDO17649.1 - 4.1e-16 59.5 0.0 8.2e-16 58.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDO17649.1 - 2.6e-15 56.5 0.0 4.9e-15 55.6 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 EDO17649.1 - 5.8e-12 45.5 0.2 8.1e-12 45.0 0.2 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_23 PF13489.6 EDO17649.1 - 4.2e-11 43.0 0.0 6.1e-11 42.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EDO17649.1 - 2e-10 41.3 0.1 5.8e-10 39.8 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.18 EDO17649.1 - 1.8e-07 30.8 0.0 2.9e-07 30.1 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_15 PF09445.10 EDO17649.1 - 1.6e-05 24.5 0.1 2.6e-05 23.9 0.1 1.3 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase PCMT PF01135.19 EDO17649.1 - 0.0045 16.8 0.0 0.008 15.9 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_4 PF02390.17 EDO17649.1 - 0.03 13.8 0.0 0.074 12.5 0.0 1.7 1 0 0 1 1 1 0 Putative methyltransferase Methyltransf_32 PF13679.6 EDO17649.1 - 0.11 12.5 0.1 0.28 11.2 0.0 1.7 2 0 0 2 2 2 0 Methyltransferase domain Sugar_tr PF00083.24 EDO17650.1 - 5.1e-28 98.1 31.9 5.1e-17 61.9 10.0 2.0 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 EDO17650.1 - 1.5e-15 57.0 45.3 3.2e-09 36.2 18.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Kinesin PF00225.23 EDO17651.1 - 6.9e-98 327.6 9.6 9.3e-98 327.2 9.6 1.1 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EDO17651.1 - 2.9e-26 92.2 0.6 9.2e-26 90.6 0.6 1.9 1 0 0 1 1 1 1 Microtubule binding AAA_22 PF13401.6 EDO17651.1 - 0.095 13.0 0.2 2.3 8.5 0.0 2.7 2 1 1 3 3 3 0 AAA domain CttA_N PF18244.1 EDO17651.1 - 0.15 12.5 1.9 0.35 11.3 0.0 2.5 3 0 0 3 3 3 0 Cellulose-binding protein CttA N-terminal domain Dynein_light PF01221.18 EDO17652.1 - 8.7e-32 109.3 0.0 9.6e-32 109.2 0.0 1.0 1 0 0 1 1 1 1 Dynein light chain type 1 PX PF00787.24 EDO17653.1 - 9.8e-16 57.7 0.7 5.4e-15 55.4 0.0 2.4 2 0 0 2 2 2 1 PX domain HofP PF10748.9 EDO17653.1 - 0.13 11.8 0.6 0.27 10.8 0.6 1.4 1 0 0 1 1 1 0 DNA utilization proteins HofP Cep57_MT_bd PF06657.13 EDO17653.1 - 0.46 11.0 12.0 1.9 9.0 0.1 3.6 4 0 0 4 4 4 0 Centrosome microtubule-binding domain of Cep57 YhdB PF14148.6 EDO17653.1 - 1.2 9.3 4.3 67 3.7 0.0 3.9 4 0 0 4 4 4 0 YhdB-like protein DDHD PF02862.17 EDO17653.1 - 5 7.2 12.0 11 6.1 5.5 2.3 2 0 0 2 2 2 0 DDHD domain Enkurin PF13864.6 EDO17653.1 - 5.9 7.4 16.1 0.32 11.4 3.2 3.7 2 1 0 2 2 2 0 Calmodulin-binding Abhydrolase_3 PF07859.13 EDO17654.1 - 3.4e-06 27.1 0.0 4.8e-06 26.6 0.0 1.4 1 1 0 1 1 1 1 alpha/beta hydrolase fold LIDHydrolase PF10230.9 EDO17654.1 - 0.018 14.6 0.1 0.032 13.8 0.1 1.4 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase DUF915 PF06028.11 EDO17654.1 - 0.03 13.6 1.0 0.049 13.0 1.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF915) Hydrolase_4 PF12146.8 EDO17654.1 - 0.048 12.9 0.0 0.1 11.8 0.0 1.6 1 1 1 2 2 2 0 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EDO17654.1 - 0.072 12.7 0.0 0.17 11.5 0.0 1.6 2 0 0 2 2 2 0 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EDO17654.1 - 0.14 12.7 0.0 0.33 11.5 0.0 1.7 1 1 0 1 1 1 0 Alpha/beta hydrolase family eIF3g PF12353.8 EDO17655.1 - 1.3e-32 112.8 0.1 1.5e-32 112.6 0.1 1.0 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit G Rad33 PF08730.10 EDO17656.1 - 3.6e-13 49.8 6.8 4.4e-08 33.3 0.6 2.1 1 1 1 2 2 2 2 Rad33 EMP24_GP25L PF01105.24 EDO17657.1 - 4.7e-41 140.7 0.1 5.4e-41 140.5 0.1 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Takusan PF04822.13 EDO17657.1 - 0.077 12.9 0.8 0.13 12.1 0.8 1.4 1 0 0 1 1 1 0 Takusan M16C_assoc PF08367.11 EDO17658.1 - 7.7e-75 251.2 0.3 1.3e-74 250.5 0.3 1.4 1 0 0 1 1 1 1 Peptidase M16C associated Peptidase_M16_C PF05193.21 EDO17658.1 - 8.9e-28 97.5 0.0 2.2e-21 76.7 0.0 2.8 2 0 0 2 2 2 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 EDO17658.1 - 1.8e-06 28.0 0.2 8.8e-06 25.8 0.0 2.1 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) UBX PF00789.20 EDO17659.1 - 2.8e-13 49.9 0.1 2.4e-10 40.5 0.0 3.3 2 1 0 2 2 2 2 UBX domain UBA_4 PF14555.6 EDO17659.1 - 5.2e-09 35.8 0.0 9.5e-09 34.9 0.0 1.4 1 0 0 1 1 1 1 UBA-like domain DUF5401 PF17380.2 EDO17659.1 - 2.6 6.0 14.8 3.6 5.5 14.8 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5401) CSRNP_N PF16019.5 EDO17659.1 - 9 6.1 7.9 19 5.1 7.9 1.5 1 0 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus PIG-S PF10510.9 EDO17660.1 - 8.6e-122 407.6 8.7 9.7e-122 407.4 8.7 1.0 1 0 0 1 1 1 1 Phosphatidylinositol-glycan biosynthesis class S protein MCM_lid PF17855.1 EDO17660.1 - 0.049 14.1 0.2 0.22 12.0 0.1 2.1 2 0 0 2 2 2 0 MCM AAA-lid domain TAFII28 PF04719.14 EDO17661.1 - 2.8e-28 97.8 0.4 1.6e-24 85.8 0.3 2.4 2 0 0 2 2 2 2 hTAFII28-like protein conserved region PBP1_TM PF14812.6 EDO17661.1 - 0.73 10.2 5.7 0.76 10.2 2.8 2.2 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal PIG-P PF08510.12 EDO17662.1 - 1.6e-31 108.7 2.5 1.9e-31 108.5 2.5 1.1 1 0 0 1 1 1 1 PIG-P DUF2208 PF09973.9 EDO17662.1 - 0.059 13.0 0.1 0.069 12.8 0.1 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2208) DUF2842 PF11003.8 EDO17662.1 - 0.73 10.1 7.6 11 6.3 7.6 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF2842) TMEM247 PF15444.6 EDO17662.1 - 3.3 7.7 4.3 17 5.4 0.2 2.2 2 0 0 2 2 2 0 Transmembrane protein 247 EamA PF00892.20 EDO17664.1 - 7.7e-14 52.0 40.4 1.7e-08 34.7 5.2 3.1 3 0 0 3 3 3 3 EamA-like transporter family DUF3955 PF13127.6 EDO17664.1 - 0.0024 17.6 6.1 0.0024 17.6 6.1 4.4 5 0 0 5 5 5 1 Protein of unknown function (DUF3955) OST3_OST6 PF04756.13 EDO17665.1 - 9.2e-71 238.6 7.6 1.1e-70 238.3 7.6 1.0 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Phage_holin_Dp1 PF16938.5 EDO17665.1 - 0.023 14.9 0.0 0.09 13.0 0.0 2.1 1 0 0 1 1 1 0 Putative phage holin Dp-1 Thioredoxin PF00085.20 EDO17665.1 - 0.06 13.3 0.0 0.11 12.5 0.0 1.5 1 0 0 1 1 1 0 Thioredoxin LRS4 PF10422.9 EDO17666.1 - 1.2e-27 97.1 16.2 1.2e-27 97.1 16.2 1.6 1 1 0 1 1 1 1 Monopolin complex subunit LRS4 V_ATPase_I PF01496.19 EDO17666.1 - 0.15 10.0 5.8 0.17 9.7 5.8 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Sec20 PF03908.13 EDO17666.1 - 0.18 11.7 5.0 0.59 10.1 5.0 1.9 1 0 0 1 1 1 0 Sec20 DUF3573 PF12097.8 EDO17666.1 - 0.35 9.7 9.1 0.65 8.8 9.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) FlxA PF14282.6 EDO17666.1 - 0.58 10.2 18.9 6.3 6.9 17.1 2.4 2 0 0 2 2 2 0 FlxA-like protein ALMT PF11744.8 EDO17666.1 - 0.86 8.4 4.0 1 8.1 4.0 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter TMPIT PF07851.13 EDO17666.1 - 3.3 6.9 6.4 4.9 6.3 6.4 1.3 1 0 0 1 1 1 0 TMPIT-like protein DGF-1_C PF11040.8 EDO17667.1 - 0.063 13.3 2.4 0.17 11.9 2.4 1.7 1 0 0 1 1 1 0 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus UDG PF03167.19 EDO17668.1 - 1.6e-22 80.1 0.0 2.5e-22 79.5 0.0 1.2 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily DOT1 PF08123.13 EDO17669.1 - 3.6e-89 297.7 0.1 9e-89 296.4 0.1 1.7 1 0 0 1 1 1 1 Histone methylation protein DOT1 CMAS PF02353.20 EDO17669.1 - 0.04 13.2 0.0 0.08 12.2 0.0 1.4 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Pribosyltran PF00156.27 EDO17670.1 - 1.6e-17 63.5 0.0 2e-17 63.2 0.0 1.1 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 EDO17670.1 - 0.0016 17.9 0.0 0.0024 17.3 0.0 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Med13_N PF11597.8 EDO17671.1 - 7.2e-64 216.1 8.4 1.3e-63 215.3 8.4 1.5 1 0 0 1 1 1 1 Mediator complex subunit 13 N-terminal Med13_C PF06333.12 EDO17671.1 - 9.9e-24 84.2 1.3 9.7e-16 57.9 0.0 3.1 2 1 1 3 3 3 2 Mediator complex subunit 13 C-terminal domain BUD22 PF09073.10 EDO17671.1 - 0.57 9.5 20.5 1.1 8.5 20.5 1.4 1 0 0 1 1 1 0 BUD22 CDC45 PF02724.14 EDO17671.1 - 3.2 5.9 15.6 5.1 5.3 15.6 1.2 1 0 0 1 1 1 0 CDC45-like protein DUF676 PF05057.14 EDO17672.1 - 3e-47 161.0 0.0 4.7e-47 160.3 0.0 1.2 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Lipase_3 PF01764.25 EDO17672.1 - 8.1e-06 25.7 0.0 1.6e-05 24.8 0.0 1.4 1 0 0 1 1 1 1 Lipase (class 3) DUF915 PF06028.11 EDO17672.1 - 0.00058 19.3 0.0 0.0011 18.4 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF915) ECM11 PF15463.6 EDO17673.1 - 1.2e-27 97.1 0.6 1.2e-27 97.1 0.6 2.2 3 0 0 3 3 3 1 Extracellular mutant protein 11 CREPT PF16566.5 EDO17673.1 - 0.0014 18.8 0.0 0.0048 17.1 0.0 1.9 1 0 0 1 1 1 1 Cell-cycle alteration and expression-elevated protein in tumour DUF948 PF06103.11 EDO17673.1 - 0.12 12.7 0.0 0.28 11.5 0.0 1.6 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) Ribosomal_L4 PF00573.22 EDO17674.1 - 4.6e-43 147.2 0.0 6.2e-43 146.7 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family DUF1729 PF08354.10 EDO17674.1 - 0.045 12.7 0.0 0.066 12.1 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1729) Homeodomain PF00046.29 EDO17675.1 - 1.4e-16 60.1 7.8 3.5e-16 58.8 7.8 1.7 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EDO17675.1 - 0.014 15.3 6.4 0.047 13.6 2.9 3.2 2 1 0 2 2 2 0 Homeobox KN domain CHDCT2 PF08074.11 EDO17675.1 - 1.7 8.8 8.7 0.17 12.1 1.2 2.3 2 0 0 2 2 2 0 CHDCT2 (NUC038) domain AhpC-TSA PF00578.21 EDO17676.1 - 2e-33 114.9 0.0 3.8e-33 114.0 0.0 1.4 2 0 0 2 2 2 1 AhpC/TSA family Redoxin PF08534.10 EDO17676.1 - 5.5e-17 61.8 0.1 1.2e-16 60.8 0.0 1.5 2 0 0 2 2 2 1 Redoxin 1-cysPrx_C PF10417.9 EDO17676.1 - 1e-10 41.3 0.4 2.7e-10 39.9 0.2 1.9 2 0 0 2 2 2 1 C-terminal domain of 1-Cys peroxiredoxin SCO1-SenC PF02630.14 EDO17676.1 - 0.021 14.7 0.1 0.043 13.7 0.1 1.5 1 0 0 1 1 1 0 SCO1/SenC Rad60-SLD PF11976.8 EDO17677.1 - 0.036 13.9 1.0 0.11 12.3 0.0 2.5 3 0 0 3 3 3 0 Ubiquitin-2 like Rad60 SUMO-like Ndc1_Nup PF09531.10 EDO17678.1 - 1.3e-107 361.1 19.1 2.2e-107 360.3 19.1 1.4 1 1 0 1 1 1 1 Nucleoporin protein Ndc1-Nup Phi-29_GP16_7 PF06720.11 EDO17678.1 - 0.096 12.5 0.4 0.68 9.8 0.2 2.1 2 0 0 2 2 2 0 Bacteriophage phi-29 early protein GP16.7 A_deaminase PF00962.22 EDO17679.1 - 2.6e-128 428.0 0.1 4.3e-128 427.3 0.1 1.4 1 0 0 1 1 1 1 Adenosine/AMP deaminase Ricin_B_lectin PF00652.22 EDO17679.1 - 0.017 15.4 2.6 0.63 10.3 0.7 2.4 2 0 0 2 2 2 0 Ricin-type beta-trefoil lectin domain DHHC PF01529.20 EDO17680.1 - 8.7e-27 93.9 8.8 8.7e-27 93.9 8.8 2.2 2 0 0 2 2 2 1 DHHC palmitoyltransferase TssC PF17541.2 EDO17680.1 - 0.039 12.8 0.1 0.056 12.3 0.1 1.1 1 0 0 1 1 1 0 Type VI secretion system, TssC, VipB Sigma70_ner PF04546.13 EDO17681.1 - 0.46 10.3 6.2 1.7 8.5 6.2 1.9 1 0 0 1 1 1 0 Sigma-70, non-essential region Redoxin PF08534.10 EDO17682.1 - 7.9e-30 103.5 0.1 9.2e-30 103.3 0.1 1.0 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 EDO17682.1 - 1.3e-05 25.1 0.0 1.7e-05 24.7 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family TPT PF03151.16 EDO17683.1 - 6e-14 52.1 20.8 4.6e-07 29.5 9.7 2.1 2 0 0 2 2 2 2 Triose-phosphate Transporter family UAA PF08449.11 EDO17683.1 - 3e-08 33.2 3.5 3e-08 33.2 3.5 2.5 2 1 0 2 2 2 1 UAA transporter family PUNUT PF16913.5 EDO17683.1 - 6.6e-08 32.1 3.6 6.6e-08 32.1 3.6 2.1 2 0 0 2 2 2 2 Purine nucleobase transmembrane transport EamA PF00892.20 EDO17683.1 - 6.9e-06 26.3 32.2 0.00068 19.8 10.1 3.8 3 1 0 3 3 3 2 EamA-like transporter family SLC35F PF06027.12 EDO17683.1 - 0.00025 20.7 0.7 0.00025 20.7 0.7 1.9 2 1 0 2 2 2 1 Solute carrier family 35 TMEM234 PF10639.9 EDO17683.1 - 0.00052 20.0 8.3 0.094 12.8 0.8 2.7 2 0 0 2 2 2 2 Putative transmembrane family 234 DUF485 PF04341.12 EDO17683.1 - 0.075 13.0 9.3 0.15 12.0 0.9 3.6 3 0 0 3 3 3 0 Protein of unknown function, DUF485 Herpes_LMP1 PF05297.11 EDO17683.1 - 0.12 11.6 0.4 0.23 10.6 0.4 1.4 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) p450 PF00067.22 EDO17684.1 - 3.5e-106 355.7 0.0 4.1e-106 355.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 YhcG_C PF06250.11 EDO17685.1 - 0.08 12.8 0.1 0.16 11.8 0.1 1.5 1 0 0 1 1 1 0 YhcG PDDEXK nuclease domain Sod_Fe_C PF02777.18 EDO17686.1 - 6.9e-31 106.4 0.8 1e-30 105.9 0.2 1.6 2 0 0 2 2 2 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.22 EDO17686.1 - 9.1e-24 83.8 0.4 1.7e-23 82.9 0.4 1.5 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain Med20 PF08612.11 EDO17687.1 - 5.1e-48 163.4 0.0 5.6e-48 163.2 0.0 1.0 1 0 0 1 1 1 1 TATA-binding related factor (TRF) of subunit 20 of Mediator complex DUF2791 PF10923.8 EDO17687.1 - 0.01 14.7 0.0 0.015 14.2 0.0 1.2 1 0 0 1 1 1 0 P-loop Domain of unknown function (DUF2791) Cucumo_coat PF00760.18 EDO17687.1 - 0.1 12.3 0.1 0.28 10.8 0.0 1.7 2 0 0 2 2 2 0 Cucumovirus coat protein CTD_bind PF04818.13 EDO17688.1 - 8.8e-16 58.5 0.7 8.8e-16 58.5 0.7 2.3 2 0 0 2 2 2 1 RNA polymerase II-binding domain. 6PGD PF00393.19 EDO17688.1 - 0.0038 16.7 0.4 0.0062 16.0 0.4 1.3 1 0 0 1 1 1 1 6-phosphogluconate dehydrogenase, C-terminal domain CTK3 PF12243.8 EDO17688.1 - 0.0049 16.9 0.7 0.0049 16.9 0.7 2.1 2 0 0 2 2 2 1 CTD kinase subunit gamma CTK3 DUF2457 PF10446.9 EDO17688.1 - 1.6 7.8 26.1 2.5 7.2 26.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Aldedh PF00171.22 EDO17689.1 - 2.8e-126 421.8 0.0 3.3e-126 421.5 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family RRF PF01765.19 EDO17690.1 - 5.8e-40 136.9 4.7 7.8e-40 136.5 4.7 1.2 1 0 0 1 1 1 1 Ribosome recycling factor Brr6_like_C_C PF10104.9 EDO17691.1 - 1e-28 99.8 4.2 1.5e-28 99.2 4.2 1.3 1 0 0 1 1 1 1 Di-sulfide bridge nucleocytoplasmic transport domain DUF2614 PF11023.8 EDO17691.1 - 0.39 10.8 2.0 6.4 6.9 0.1 2.7 3 0 0 3 3 3 0 Zinc-ribbon containing domain Pyridoxal_deC PF00282.19 EDO17692.1 - 2e-21 76.1 0.0 3.5e-21 75.4 0.0 1.4 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.19 EDO17692.1 - 3.5e-06 26.2 0.0 2.3e-05 23.5 0.0 1.9 1 1 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 EDO17692.1 - 1.8e-05 24.2 0.0 3.4e-05 23.3 0.0 1.4 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family HDA2-3 PF11496.8 EDO17693.1 - 3.6e-69 233.1 11.7 3.6e-69 233.1 11.7 2.0 2 1 0 2 2 2 1 Class II histone deacetylase complex subunits 2 and 3 YabA PF06156.13 EDO17693.1 - 0.3 11.7 12.3 0.24 12.1 3.1 3.1 2 0 0 2 2 2 0 Initiation control protein YabA Fez1 PF06818.15 EDO17693.1 - 1.6 9.2 16.9 1.9 8.9 13.6 2.3 1 1 1 2 2 2 0 Fez1 Exonuc_VII_L PF02601.15 EDO17693.1 - 1.6 8.2 5.9 3.6 7.1 5.9 1.7 1 0 0 1 1 1 0 Exonuclease VII, large subunit Sec23_trunk PF04811.15 EDO17694.1 - 5.3e-13 49.1 0.4 2.1e-12 47.2 0.1 1.9 1 1 1 2 2 2 1 Sec23/Sec24 trunk domain Mhr1 PF12829.7 EDO17695.1 - 3.4e-26 91.2 0.9 5.9e-26 90.4 0.9 1.4 1 0 0 1 1 1 1 Transcriptional regulation of mitochondrial recombination OSCP PF00213.18 EDO17696.1 - 9e-47 159.4 2.2 1e-46 159.2 2.2 1.0 1 0 0 1 1 1 1 ATP synthase delta (OSCP) subunit AATF-Che1 PF13339.6 EDO17697.1 - 1.5e-24 87.2 7.0 1.5e-24 87.2 7.0 3.6 3 1 0 3 3 3 1 Apoptosis antagonizing transcription factor TRAUB PF08164.12 EDO17697.1 - 3.5e-24 85.1 0.1 3.5e-24 85.1 0.1 3.4 2 1 1 3 3 3 1 Apoptosis-antagonizing transcription factor, C-terminal Pkinase PF00069.25 EDO17698.1 - 3.1e-56 190.7 0.0 3.6e-56 190.4 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO17698.1 - 2.1e-31 109.1 0.0 2.6e-31 108.9 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EDO17698.1 - 0.00033 19.7 0.1 0.0005 19.1 0.1 1.3 1 1 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 EDO17698.1 - 0.014 14.7 0.0 0.023 14.1 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family WD40 PF00400.32 EDO17698.1 - 0.017 16.0 0.1 0.13 13.2 0.0 2.5 3 0 0 3 3 3 0 WD domain, G-beta repeat APH PF01636.23 EDO17698.1 - 0.036 14.0 0.1 0.082 12.8 0.1 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family PIF1 PF05970.14 EDO17699.1 - 5.3e-52 177.2 6.8 1.8e-43 149.1 0.1 2.7 2 1 0 3 3 3 2 PIF1-like helicase AAA_30 PF13604.6 EDO17699.1 - 6.2e-23 81.5 0.0 1.5e-22 80.3 0.0 1.6 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 EDO17699.1 - 1.8e-08 34.9 0.0 4.3e-08 33.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EDO17699.1 - 1.7e-06 28.4 0.1 1.1e-05 25.7 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_7 PF12775.7 EDO17699.1 - 0.00017 21.1 0.1 0.00069 19.2 0.1 2.0 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_5 PF07728.14 EDO17699.1 - 0.0012 18.8 0.3 0.013 15.5 0.0 2.8 3 0 0 3 3 3 1 AAA domain (dynein-related subfamily) SH3_13 PF18335.1 EDO17699.1 - 0.0024 17.7 0.0 0.0088 15.9 0.0 2.0 1 0 0 1 1 1 1 ATP-dependent RecD-like DNA helicase SH3 domain AAA_16 PF13191.6 EDO17699.1 - 0.0033 17.8 0.5 0.57 10.5 0.4 3.2 2 1 0 2 2 2 1 AAA ATPase domain PhoH PF02562.16 EDO17699.1 - 0.006 16.1 0.2 0.057 12.9 0.0 2.6 2 1 1 3 3 3 1 PhoH-like protein AAA PF00004.29 EDO17699.1 - 0.0092 16.4 2.8 0.039 14.4 0.0 2.8 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) T2SSE PF00437.20 EDO17699.1 - 0.0095 15.0 0.1 0.027 13.6 0.1 1.7 1 0 0 1 1 1 1 Type II/IV secretion system protein UvrD_C_2 PF13538.6 EDO17699.1 - 0.017 15.0 0.3 0.11 12.3 0.3 2.4 1 1 0 1 1 1 0 UvrD-like helicase C-terminal domain Helicase_RecD PF05127.14 EDO17699.1 - 0.074 12.9 0.6 1.3 8.8 0.2 2.9 2 1 0 2 2 2 0 Helicase Mg_chelatase PF01078.21 EDO17699.1 - 0.11 11.8 0.1 0.32 10.3 0.0 1.7 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI Calcipressin PF04847.12 EDO17700.1 - 1e-22 80.8 0.3 2.3e-22 79.6 0.3 1.6 1 1 0 1 1 1 1 Calcipressin Peptidase_M1 PF01433.20 EDO17701.1 - 3e-88 295.0 6.2 6.9e-88 293.8 6.2 1.7 1 0 0 1 1 1 1 Peptidase family M1 domain ERAP1_C PF11838.8 EDO17701.1 - 5.2e-81 272.6 2.6 8.6e-80 268.6 0.3 2.6 3 0 0 3 3 3 2 ERAP1-like C-terminal domain Peptidase_M1_N PF17900.1 EDO17701.1 - 5.1e-53 180.0 2.1 1.1e-52 178.9 2.1 1.6 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain HEAT_2 PF13646.6 EDO17701.1 - 0.019 15.3 0.0 6 7.3 0.0 2.5 2 0 0 2 2 2 0 HEAT repeats HAD_2 PF13419.6 EDO17702.1 - 1.9e-17 63.9 0.0 3.3e-17 63.1 0.0 1.4 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EDO17702.1 - 2.6e-06 27.9 0.0 0.0011 19.3 0.0 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase DUF155 PF02582.14 EDO17703.1 - 3.5e-44 151.0 0.2 7.2e-44 150.0 0.2 1.5 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 Inositol_P PF00459.25 EDO17704.1 - 1.5e-67 228.0 0.0 1.7e-67 227.8 0.0 1.0 1 0 0 1 1 1 1 Inositol monophosphatase family EXS PF03124.14 EDO17705.1 - 3.2e-73 246.9 32.0 5e-73 246.3 32.0 1.3 1 0 0 1 1 1 1 EXS family SPX PF03105.19 EDO17705.1 - 3.7e-31 109.4 1.1 1.3e-19 71.4 0.1 2.4 1 1 1 2 2 2 2 SPX domain DUF2207 PF09972.9 EDO17705.1 - 1.4 7.6 7.7 9.5 4.8 4.8 2.4 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) PhoLip_ATPase_C PF16212.5 EDO17706.1 - 2.9e-50 171.4 19.5 2.9e-50 171.4 19.5 1.9 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EDO17706.1 - 3.7e-16 58.6 3.2 3.7e-16 58.6 3.2 2.6 2 0 0 2 2 2 1 Phospholipid-translocating ATPase N-terminal E1-E2_ATPase PF00122.20 EDO17706.1 - 2.7e-14 53.1 1.1 5.8e-14 52.0 0.1 2.1 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 EDO17706.1 - 7.5e-12 46.0 0.0 9.6e-08 32.6 0.0 2.7 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EDO17706.1 - 4.8e-09 36.2 0.0 6.3e-08 32.6 0.0 2.3 2 0 0 2 2 2 1 Cation transport ATPase (P-type) B-block_TFIIIC PF04182.12 EDO17706.1 - 0.013 15.7 0.1 0.16 12.1 0.0 2.6 2 0 0 2 2 2 0 B-block binding subunit of TFIIIC Hydrolase_3 PF08282.12 EDO17706.1 - 0.037 13.8 0.0 0.037 13.8 0.0 3.4 3 1 0 3 3 3 0 haloacid dehalogenase-like hydrolase Transp_cyt_pur PF02133.15 EDO17707.1 - 1.1e-84 284.8 36.1 1.3e-84 284.6 36.1 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Ribosomal_L34e PF01199.18 EDO17708.1 - 2.1e-40 136.9 5.4 2.1e-40 136.9 5.4 1.8 2 0 0 2 2 2 1 Ribosomal protein L34e Ribonuc_L-PSP PF01042.21 EDO17709.1 - 9.9e-41 138.6 0.6 1.1e-40 138.4 0.6 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP Cyclin PF08613.11 EDO17710.1 - 3.1e-41 141.4 2.7 2.5e-25 89.7 0.7 3.1 2 1 1 3 3 3 2 Cyclin Zip PF02535.22 EDO17710.1 - 0.016 14.5 0.5 0.018 14.3 0.5 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Apc15p PF05841.11 EDO17710.1 - 0.063 14.1 12.7 0.11 13.2 12.7 1.4 1 0 0 1 1 1 0 Apc15p protein NPR3 PF03666.13 EDO17710.1 - 0.083 11.7 5.7 0.1 11.4 5.7 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Macoilin PF09726.9 EDO17710.1 - 0.094 11.3 7.1 0.1 11.2 7.1 1.1 1 0 0 1 1 1 0 Macoilin family RP-C_C PF11800.8 EDO17710.1 - 0.16 12.0 0.6 0.22 11.6 0.6 1.2 1 0 0 1 1 1 0 Replication protein C C-terminal region Presenilin PF01080.17 EDO17710.1 - 0.66 8.7 6.4 0.86 8.3 6.4 1.1 1 0 0 1 1 1 0 Presenilin PNISR PF15996.5 EDO17710.1 - 6.3 7.0 8.0 9 6.5 8.0 1.1 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR DUF2547 PF10818.8 EDO17710.1 - 8.5 7.4 6.5 4.9 8.2 3.0 2.3 2 1 1 3 3 3 0 Protein of unknown function (DUF2547) DUF2841 PF11001.8 EDO17711.1 - 1.1e-35 122.3 2.8 2e-35 121.5 2.8 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2841) Fungal_trans PF04082.18 EDO17712.1 - 1.6e-38 132.3 5.3 3e-38 131.4 5.3 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDO17712.1 - 6.2e-09 35.8 10.8 1.2e-08 34.9 10.8 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DHHC PF01529.20 EDO17713.1 - 2.8e-27 95.4 12.4 2.8e-27 95.4 12.4 2.5 2 0 0 2 2 2 2 DHHC palmitoyltransferase DHQ_synthase PF01761.20 EDO17714.1 - 1.6e-69 234.0 0.2 2.5e-69 233.4 0.2 1.3 1 0 0 1 1 1 1 3-dehydroquinate synthase Fe-ADH_2 PF13685.6 EDO17714.1 - 2.1e-06 27.6 0.0 2.8e-06 27.2 0.0 1.2 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH PF00465.19 EDO17714.1 - 0.033 13.0 0.0 0.08 11.7 0.0 1.6 1 1 0 1 1 1 0 Iron-containing alcohol dehydrogenase Zn_ribbon_17 PF17120.5 EDO17715.1 - 3.5e-18 65.0 15.2 8.1e-18 63.8 15.2 1.7 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type RWD PF05773.22 EDO17715.1 - 4.5e-06 26.9 0.1 2.1e-05 24.8 0.0 2.2 2 0 0 2 2 2 1 RWD domain WD40 PF00400.32 EDO17715.1 - 8.7e-06 26.4 24.1 0.00012 22.8 0.1 6.2 6 0 0 6 6 6 3 WD domain, G-beta repeat zf-RING_2 PF13639.6 EDO17715.1 - 0.0053 17.1 12.0 0.015 15.6 12.0 1.8 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 EDO17715.1 - 0.0078 16.5 10.9 0.02 15.2 10.9 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 EDO17715.1 - 0.088 12.7 11.2 0.2 11.5 11.2 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zinc_ribbon_16 PF17034.5 EDO17715.1 - 0.1 12.8 10.7 0.37 11.0 10.7 2.0 1 0 0 1 1 1 0 Zinc-ribbon like family zf-C3HC4 PF00097.25 EDO17715.1 - 5.4 7.0 12.6 15 5.5 12.6 1.8 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) adh_short PF00106.25 EDO17716.1 - 2.4e-11 43.4 0.0 1.2e-10 41.1 0.0 2.1 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EDO17716.1 - 0.017 14.7 0.0 0.062 12.8 0.0 1.9 2 1 0 2 2 2 0 Enoyl-(Acyl carrier protein) reductase TMEM135_C_rich PF15982.5 EDO17716.1 - 0.12 12.9 1.1 0.34 11.5 0.6 1.9 1 1 1 2 2 2 0 N-terminal cysteine-rich region of Transmembrane protein 135 ANAPC9 PF12856.7 EDO17717.1 - 1.6e-19 70.2 0.2 1.6e-19 70.2 0.2 1.9 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 9 RGI1 PF10843.8 EDO17717.1 - 0.012 15.3 0.6 0.021 14.5 0.6 1.4 1 0 0 1 1 1 0 Respiratory growth induced protein 1 CDC45 PF02724.14 EDO17718.1 - 6.1e-217 721.9 2.7 6.9e-217 721.7 2.7 1.0 1 0 0 1 1 1 1 CDC45-like protein YL1 PF05764.13 EDO17718.1 - 0.00075 19.7 18.5 0.0029 17.8 13.5 2.1 2 0 0 2 2 2 1 YL1 nuclear protein Nrf1_DNA-bind PF10491.9 EDO17718.1 - 0.1 12.3 0.0 0.18 11.5 0.0 1.3 1 0 0 1 1 1 0 NLS-binding and DNA-binding and dimerisation domains of Nrf1 MMR_HSR1_C PF08438.10 EDO17718.1 - 0.12 12.9 0.1 0.38 11.3 0.1 1.9 1 0 0 1 1 1 0 GTPase of unknown function C-terminal Nop14 PF04147.12 EDO17718.1 - 1.8 6.6 28.5 0.8 7.8 21.6 2.1 2 0 0 2 2 2 0 Nop14-like family RRN3 PF05327.11 EDO17718.1 - 8.5 4.8 19.8 1.1 7.7 12.2 2.2 2 0 0 2 2 2 0 RNA polymerase I specific transcription initiation factor RRN3 CHORD PF04968.12 EDO17720.1 - 0.0011 19.6 4.6 0.0021 18.7 4.6 1.5 1 0 0 1 1 1 1 CHORD Mononeg_mRNAcap PF14318.6 EDO17720.1 - 0.14 11.4 2.4 8.7 5.5 0.0 2.1 1 1 1 2 2 2 0 Mononegavirales mRNA-capping region V NARG2_C PF10505.9 EDO17720.1 - 0.14 11.6 0.8 0.24 10.9 0.8 1.3 1 0 0 1 1 1 0 NMDA receptor-regulated gene protein 2 C-terminus FIN1 PF17300.2 EDO17721.1 - 7.3e-82 274.5 12.2 8.5e-82 274.3 12.2 1.0 1 0 0 1 1 1 1 Filaments in between nuclei protein-1 Imm9 PF15587.6 EDO17721.1 - 0.069 12.8 0.1 0.13 11.9 0.1 1.4 1 0 0 1 1 1 0 Immunity protein 9 BTB_2 PF02214.22 EDO17722.1 - 3.8e-09 36.8 0.3 2.8e-05 24.4 0.0 2.8 2 1 0 2 2 2 2 BTB/POZ domain ABC_membrane PF00664.23 EDO17723.1 - 1.4e-90 303.7 36.0 8.9e-47 160.0 14.7 3.0 3 0 0 3 3 3 2 ABC transporter transmembrane region ABC_tran PF00005.27 EDO17723.1 - 7.7e-50 169.0 0.2 5.8e-31 107.8 0.2 2.8 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EDO17723.1 - 9.9e-12 44.8 4.7 1.3e-06 28.0 1.0 3.9 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 EDO17723.1 - 9.1e-06 25.7 0.4 0.092 12.8 0.1 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_29 PF13555.6 EDO17723.1 - 0.00015 21.4 0.3 0.87 9.4 0.0 2.8 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 EDO17723.1 - 0.002 18.5 0.1 0.48 10.8 0.0 2.5 2 0 0 2 2 2 1 AAA ATPase domain UPF0093 PF03653.13 EDO17723.1 - 0.0026 18.0 0.8 0.011 16.0 0.8 2.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0093) RsgA_GTPase PF03193.16 EDO17723.1 - 0.0027 17.6 0.1 1.6 8.6 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase IstB_IS21 PF01695.17 EDO17723.1 - 0.017 14.9 0.2 4.9 6.8 0.0 3.4 3 0 0 3 3 3 0 IstB-like ATP binding protein AAA_21 PF13304.6 EDO17723.1 - 0.021 14.6 2.8 2.2 8.0 0.1 2.9 2 1 0 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system Dynamin_N PF00350.23 EDO17723.1 - 0.026 14.6 0.8 0.79 9.8 0.0 2.6 2 0 0 2 2 2 0 Dynamin family AAA_22 PF13401.6 EDO17723.1 - 0.028 14.7 0.6 15 5.8 0.0 3.1 3 1 0 3 3 2 0 AAA domain DUF87 PF01935.17 EDO17723.1 - 0.034 14.3 6.8 0.36 10.9 0.1 3.4 3 0 0 3 3 3 0 Helicase HerA, central domain AAA_25 PF13481.6 EDO17723.1 - 0.049 13.2 0.6 3.2 7.3 0.0 2.9 3 0 0 3 3 3 0 AAA domain AAA_7 PF12775.7 EDO17723.1 - 0.05 13.1 0.1 4.7 6.7 0.0 2.5 2 0 0 2 2 2 0 P-loop containing dynein motor region Roc PF08477.13 EDO17723.1 - 0.16 12.2 1.4 21 5.4 0.0 3.0 3 0 0 3 3 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_30 PF13604.6 EDO17723.1 - 0.23 11.1 1.2 12 5.5 0.3 2.8 2 1 0 2 2 2 0 AAA domain AAA_15 PF13175.6 EDO17723.1 - 0.67 9.6 9.9 1.7 8.2 0.3 3.3 3 1 0 3 3 3 0 AAA ATPase domain AAA_23 PF13476.6 EDO17723.1 - 4.7 7.6 13.7 0.77 10.2 0.1 3.4 4 0 0 4 4 3 0 AAA domain AIG1 PF04548.16 EDO17723.1 - 8 5.7 9.8 0.46 9.8 0.1 3.0 3 0 0 3 3 3 0 AIG1 family Metallophos PF00149.28 EDO17724.1 - 1.4e-37 130.2 0.0 2.4e-37 129.4 0.0 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 EDO17724.1 - 2.3e-16 60.0 0.0 4.9e-16 58.9 0.0 1.6 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain UCH_1 PF13423.6 EDO17725.1 - 3.8e-64 217.3 9.3 6.9e-64 216.4 9.3 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase RNase_T PF00929.24 EDO17725.1 - 2.7e-23 83.3 0.0 5.7e-23 82.3 0.0 1.6 1 0 0 1 1 1 1 Exonuclease UCH PF00443.29 EDO17725.1 - 2.1e-08 34.0 6.0 2.1e-08 34.0 6.0 2.4 3 0 0 3 3 3 1 Ubiquitin carboxyl-terminal hydrolase ANAPC4_WD40 PF12894.7 EDO17725.1 - 0.038 14.3 0.0 0.16 12.3 0.0 2.0 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin2 PF04096.14 EDO17726.1 - 2.8e-47 160.5 0.0 7.7e-47 159.1 0.0 1.8 1 0 0 1 1 1 1 Nucleoporin autopeptidase Nup96 PF12110.8 EDO17726.1 - 5.7e-34 117.6 0.0 2e-31 109.2 0.0 2.4 1 1 0 1 1 1 1 Nuclear protein 96 Nucleoporin_FG PF13634.6 EDO17726.1 - 3e-16 60.0 81.7 1.5e-14 54.6 28.0 4.7 2 1 2 4 4 4 3 Nucleoporin FG repeat region TBP-binding PF09247.11 EDO17726.1 - 8.5 6.7 7.0 5.6 7.3 0.0 4.2 4 0 0 4 4 4 0 TATA box-binding protein binding MF_alpha_N PF05436.11 EDO17727.1 - 1.3e-34 118.0 0.2 2.7e-34 116.9 0.2 1.6 1 0 0 1 1 1 1 Mating factor alpha precursor N-terminus MF_alpha PF04648.12 EDO17727.1 - 3.5e-25 87.2 45.0 5.3e-06 26.5 5.3 4.4 4 0 0 4 4 4 4 Yeast mating factor alpha hormone BHD_1 PF10403.9 EDO17727.1 - 0.0055 16.5 0.2 30 4.6 0.0 3.3 3 0 0 3 3 3 3 Rad4 beta-hairpin domain 1 SH3_9 PF14604.6 EDO17727.1 - 0.025 14.4 0.0 92 3.0 0.0 3.9 4 0 0 4 4 4 0 Variant SH3 domain CinA_KH PF18146.1 EDO17728.1 - 1.4 9.1 5.0 21 5.3 0.1 3.7 4 0 0 4 4 4 0 Damage-inducible protein CinA KH domain ApoO PF09769.9 EDO17728.1 - 3.7 7.5 20.3 11 6.0 1.1 5.7 2 2 3 5 5 5 0 Apolipoprotein O COA2 PF17051.5 EDO17729.1 - 2.8e-16 59.4 0.3 2.9e-16 59.3 0.3 1.0 1 0 0 1 1 1 1 Cytochrome C oxidase assembly factor 2 RRM_1 PF00076.22 EDO17730.1 - 2.9e-10 39.8 0.2 7.4e-10 38.5 0.2 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FHA PF00498.26 EDO17731.1 - 2.2e-05 24.7 0.6 6.5e-05 23.2 0.1 2.2 1 1 0 1 1 1 1 FHA domain EloA-BP1 PF15870.5 EDO17732.1 - 0.02 15.2 6.8 0.041 14.1 6.8 1.5 1 1 0 1 1 1 0 ElonginA binding-protein 1 DUF359 PF04019.12 EDO17732.1 - 0.16 11.6 1.1 0.26 10.9 1.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF359) Macoilin PF09726.9 EDO17732.1 - 1.3 7.5 8.3 1.2 7.6 8.3 1.0 1 0 0 1 1 1 0 Macoilin family Synthase_beta PF11421.8 EDO17732.1 - 9 7.1 13.3 7.1 7.4 4.5 2.5 1 1 1 2 2 2 0 ATP synthase F1 beta subunit MPC PF03650.13 EDO17733.1 - 9.1e-42 141.7 0.1 1.1e-41 141.4 0.1 1.0 1 0 0 1 1 1 1 Mitochondrial pyruvate carriers TLD PF07534.16 EDO17734.1 - 7.5e-27 94.3 0.0 3e-26 92.3 0.0 1.9 1 1 0 1 1 1 1 TLD DEAD PF00270.29 EDO17735.1 - 2.8e-53 180.3 0.0 2.2e-52 177.4 0.0 2.3 2 1 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDO17735.1 - 4.8e-36 123.5 0.3 3.5e-30 104.6 0.1 3.3 2 1 1 3 3 3 2 Helicase conserved C-terminal domain ERCC3_RAD25_C PF16203.5 EDO17735.1 - 0.00036 19.8 0.1 0.00036 19.8 0.1 2.3 2 0 0 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase UTP25 PF06862.12 EDO17735.1 - 0.0053 15.6 0.2 0.0053 15.6 0.2 3.1 3 1 1 4 4 3 1 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 CMS1 PF14617.6 EDO17735.1 - 0.011 15.1 0.0 0.011 15.1 0.0 2.9 2 1 0 2 2 1 0 U3-containing 90S pre-ribosomal complex subunit AAA_30 PF13604.6 EDO17735.1 - 0.023 14.4 0.0 0.26 11.0 0.0 2.3 2 0 0 2 2 2 0 AAA domain DotA PF11388.8 EDO17735.1 - 0.028 14.6 0.1 0.079 13.2 0.1 1.8 1 0 0 1 1 1 0 Phagosome trafficking protein DotA Prismane PF03063.20 EDO17735.1 - 0.17 10.5 6.0 0.044 12.5 2.5 1.7 2 0 0 2 2 2 0 Prismane/CO dehydrogenase family DDRGK PF09756.9 EDO17735.1 - 0.17 11.4 22.7 0.44 10.1 22.7 1.7 1 0 0 1 1 1 0 DDRGK domain Rhodanese PF00581.20 EDO17735.1 - 0.28 11.7 0.0 0.28 11.7 0.0 2.4 2 0 0 2 2 2 0 Rhodanese-like domain Zip PF02535.22 EDO17735.1 - 0.3 10.2 3.5 0.39 9.9 3.5 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter GREB1 PF15782.5 EDO17735.1 - 1.3 6.0 5.4 9.5 3.2 0.0 2.0 2 0 0 2 2 2 0 Gene regulated by oestrogen in breast cancer AP3D1 PF06375.11 EDO17735.1 - 2.9 8.1 29.1 7.9 6.7 29.1 1.7 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 Vfa1 PF08432.10 EDO17735.1 - 3.5 7.9 25.4 8.5 6.7 25.4 1.7 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 AA_permease_2 PF13520.6 EDO17736.1 - 2.2e-51 175.0 44.3 2.7e-51 174.8 44.3 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EDO17736.1 - 8.9e-22 77.3 36.0 1.2e-21 76.9 36.0 1.0 1 0 0 1 1 1 1 Amino acid permease Ribosomal_S17 PF00366.20 EDO17736.1 - 0.087 12.9 0.0 0.18 11.9 0.0 1.5 1 0 0 1 1 1 0 Ribosomal protein S17 Ribosomal_L30 PF00327.20 EDO17737.1 - 8.5e-19 67.2 1.6 1.8e-18 66.1 1.6 1.6 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e Ribosomal_L30_N PF08079.12 EDO17737.1 - 3.9e-13 49.5 6.4 6.8e-13 48.7 6.4 1.4 1 0 0 1 1 1 1 Ribosomal L30 N-terminal domain DUF1771 PF08590.10 EDO17738.1 - 2.3e-17 63.1 3.7 3.1e-17 62.7 3.7 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1771) CD225 PF04505.12 EDO17738.1 - 0.027 14.6 0.4 0.04 14.1 0.4 1.2 1 0 0 1 1 1 0 Interferon-induced transmembrane protein Rnk_N PF14760.6 EDO17738.1 - 0.11 13.1 0.0 0.2 12.1 0.0 1.5 1 0 0 1 1 1 0 Rnk N-terminus Seryl_tRNA_N PF02403.22 EDO17738.1 - 0.11 12.7 1.8 0.13 12.5 1.8 1.1 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain MPS2 PF17060.5 EDO17739.1 - 7.7e-67 226.1 9.7 9.4e-67 225.9 9.7 1.0 1 0 0 1 1 1 1 Monopolar spindle protein 2 DUF2634 PF10934.8 EDO17739.1 - 0.019 15.0 0.8 4.7 7.4 0.1 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF2634) SlyX PF04102.12 EDO17739.1 - 0.23 12.1 2.2 1.8 9.2 0.1 2.3 2 0 0 2 2 2 0 SlyX FAM76 PF16046.5 EDO17739.1 - 1.9 7.7 4.6 2.1 7.6 3.4 1.6 1 1 1 2 2 2 0 FAM76 protein HSF_DNA-bind PF00447.17 EDO17740.1 - 4.6e-30 104.1 1.3 9.3e-30 103.1 1.3 1.5 1 0 0 1 1 1 1 HSF-type DNA-binding AFT PF08731.11 EDO17742.1 - 2.7e-40 137.2 4.9 2.7e-40 137.2 4.9 3.2 2 2 0 2 2 2 1 Transcription factor AFT DBD_Tnp_Mut PF03108.15 EDO17742.1 - 0.0037 17.2 0.4 3.6 7.6 0.0 2.7 2 0 0 2 2 2 2 MuDR family transposase RNA_POL_M_15KD PF02150.16 EDO17743.1 - 4.7e-17 61.6 4.1 4.7e-17 61.6 4.1 2.9 3 0 0 3 3 3 1 RNA polymerases M/15 Kd subunit TFIIS_C PF01096.18 EDO17743.1 - 2.5e-14 52.8 15.2 1.4e-13 50.5 2.5 3.1 3 0 0 3 3 3 2 Transcription factor S-II (TFIIS) DUF2387 PF09526.10 EDO17743.1 - 0.0028 17.8 4.2 0.47 10.6 0.6 2.4 2 1 0 2 2 2 2 Probable metal-binding protein (DUF2387) DZR PF12773.7 EDO17743.1 - 0.018 15.0 6.5 1.4 9.0 0.4 2.5 2 1 0 2 2 2 0 Double zinc ribbon zf-UBP PF02148.19 EDO17743.1 - 0.033 14.5 3.9 0.39 11.1 0.4 2.3 2 0 0 2 2 2 0 Zn-finger in ubiquitin-hydrolases and other protein Zn_Tnp_IS1595 PF12760.7 EDO17743.1 - 0.13 12.3 10.0 1.1 9.3 2.4 2.6 2 1 0 2 2 2 0 Transposase zinc-ribbon domain Cytochrom_c3_2 PF14537.6 EDO17743.1 - 1.3 9.6 6.0 0.35 11.3 0.6 2.1 2 1 0 2 2 2 0 Cytochrome c3 Lar_restr_allev PF14354.6 EDO17743.1 - 2 8.9 6.8 0.42 11.0 0.3 2.5 2 1 0 2 2 2 0 Restriction alleviation protein Lar Rubredoxin PF00301.20 EDO17743.1 - 2.1 8.4 5.6 39 4.4 0.2 3.3 4 0 0 4 4 4 0 Rubredoxin Cytochrome_C7 PF14522.6 EDO17743.1 - 2.9 7.9 7.3 34 4.5 7.3 2.6 1 1 0 1 1 1 0 Cytochrome c7 and related cytochrome c Nudix_N_2 PF14803.6 EDO17743.1 - 5.2 7.1 11.0 7.8 6.5 1.5 3.4 3 1 0 3 3 3 0 Nudix N-terminal Pkinase PF00069.25 EDO17744.1 - 6.6e-74 248.6 0.3 8.7e-74 248.2 0.0 1.3 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO17744.1 - 9.3e-40 136.5 0.0 1.3e-39 136.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDO17744.1 - 6.8e-07 28.9 0.1 2.1e-06 27.3 0.0 1.9 1 1 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 EDO17744.1 - 0.00082 18.4 3.8 0.0014 17.6 3.8 1.3 1 0 0 1 1 1 1 Haspin like kinase domain Seadorna_VP7 PF07387.11 EDO17744.1 - 0.066 12.3 0.0 0.13 11.2 0.0 1.4 1 0 0 1 1 1 0 Seadornavirus VP7 APH PF01636.23 EDO17744.1 - 0.17 11.8 0.0 0.44 10.4 0.0 1.6 1 1 0 1 1 1 0 Phosphotransferase enzyme family Pkinase PF00069.25 EDO17745.1 - 5.3e-17 62.0 0.0 1.3e-16 60.7 0.0 1.7 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO17745.1 - 2.9e-10 39.9 0.0 6e-10 38.8 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EDO17745.1 - 2.2e-08 33.3 0.1 2.2e-08 33.3 0.1 2.5 2 1 0 2 2 2 1 Fungal protein kinase Roughex PF06020.11 EDO17745.1 - 0.013 14.6 7.5 0.022 13.9 7.5 1.3 1 0 0 1 1 1 0 Drosophila roughex protein APH PF01636.23 EDO17745.1 - 0.036 14.0 0.0 0.072 13.0 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family JAB PF01398.21 EDO17746.1 - 4.9e-32 110.4 0.3 4.9e-32 110.4 0.3 1.9 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.6 EDO17746.1 - 2.9e-11 43.8 1.5 7e-11 42.5 1.5 1.7 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function Prok-JAB PF14464.6 EDO17746.1 - 2.7e-07 30.4 0.0 4.3e-07 29.7 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain UPF0172 PF03665.13 EDO17746.1 - 0.04 14.0 1.3 0.097 12.7 0.0 2.1 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0172) Peptidase_M24 PF00557.24 EDO17747.1 - 3.7e-59 199.9 0.0 4.7e-59 199.6 0.0 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.16 EDO17747.1 - 3.7e-24 84.8 0.0 9.5e-24 83.5 0.0 1.7 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain DUF3793 PF12672.7 EDO17747.1 - 0.0036 17.4 0.1 0.0083 16.2 0.1 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF3793) PGM_PMM_I PF02878.16 EDO17748.1 - 3.4e-34 117.5 0.1 5.1e-34 117.0 0.1 1.3 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_III PF02880.16 EDO17748.1 - 1.6e-25 89.5 0.0 2.8e-25 88.7 0.0 1.4 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.16 EDO17748.1 - 5.7e-11 43.0 0.0 1.3e-10 41.8 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.20 EDO17748.1 - 6.7e-06 26.2 0.0 1.4e-05 25.1 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain Fer4_12 PF13353.6 EDO17748.1 - 0.11 12.7 0.1 0.65 10.3 0.0 2.1 2 0 0 2 2 2 0 4Fe-4S single cluster domain RRN3 PF05327.11 EDO17749.1 - 4.8e-184 613.0 11.8 5.6e-184 612.8 11.8 1.0 1 0 0 1 1 1 1 RNA polymerase I specific transcription initiation factor RRN3 DUF1319 PF07028.11 EDO17749.1 - 0.049 13.9 1.0 2.9 8.2 0.2 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1319) Nop14 PF04147.12 EDO17749.1 - 0.26 9.5 13.6 0.36 9.0 12.9 1.5 1 1 1 2 2 2 0 Nop14-like family DUF1539 PF07560.11 EDO17749.1 - 0.27 11.3 5.9 0.12 12.4 0.4 3.3 4 1 0 4 4 4 0 Domain of Unknown Function (DUF1539) DUF4404 PF14357.6 EDO17749.1 - 2.5 8.8 6.3 3 8.5 4.5 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4404) SRP9-21 PF05486.12 EDO17750.1 - 1.4e-15 57.5 0.3 1.4e-15 57.5 0.3 3.2 3 1 0 3 3 3 1 Signal recognition particle 9 kDa protein (SRP9) LAM_C PF12544.8 EDO17750.1 - 0.33 11.1 5.3 0.48 10.6 5.3 1.5 1 1 0 1 1 1 0 Lysine-2,3-aminomutase WD40 PF00400.32 EDO17751.1 - 7.5e-20 70.9 16.3 9.7e-06 26.2 0.2 7.0 7 0 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDO17751.1 - 1.7e-07 31.4 0.1 0.39 11.0 0.0 4.6 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EDO17751.1 - 0.00044 19.3 0.0 0.0047 15.9 0.0 2.6 4 0 0 4 4 4 1 WD40 region of Ge1, enhancer of mRNA-decapping protein TF_Zn_Ribbon PF08271.12 EDO17751.1 - 0.32 10.6 1.9 0.9 9.1 1.9 1.9 1 1 0 1 1 1 0 TFIIB zinc-binding DUF4808 PF16066.5 EDO17751.1 - 4.3 7.9 12.3 7.4 7.2 0.9 3.6 4 0 0 4 4 4 0 Domain of unknown function (DUF4808) zf-RRN7 PF11781.8 EDO17751.1 - 5.6 6.7 5.6 10 5.9 0.8 2.5 2 0 0 2 2 2 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 Prenyltransf PF01255.19 EDO17752.1 - 2.8e-58 197.1 0.1 3.7e-58 196.7 0.1 1.1 1 0 0 1 1 1 1 Putative undecaprenyl diphosphate synthase SHP PF03579.13 EDO17752.1 - 0.0011 18.8 0.2 0.0011 18.8 0.2 2.1 2 0 0 2 2 2 1 Small hydrophobic protein zf-MYND PF01753.18 EDO17753.1 - 3.2e-07 30.3 19.4 7.7e-07 29.1 19.4 1.7 1 1 0 1 1 1 1 MYND finger Arm PF00514.23 EDO17753.1 - 0.067 13.3 0.0 21 5.3 0.0 2.7 2 0 0 2 2 2 0 Armadillo/beta-catenin-like repeat Aldose_epim PF01263.20 EDO17755.1 - 5e-48 164.0 0.2 5.8e-48 163.7 0.2 1.0 1 0 0 1 1 1 1 Aldose 1-epimerase DUF5505 PF17610.2 EDO17755.1 - 0.1 12.6 0.1 0.17 11.9 0.1 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5505) Pkinase PF00069.25 EDO17756.1 - 4.1e-44 150.9 0.0 6.7e-44 150.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO17756.1 - 4.3e-23 81.9 0.0 2.2e-22 79.6 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EDO17756.1 - 0.008 15.6 0.0 0.016 14.5 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EDO17756.1 - 0.089 12.1 0.0 0.14 11.5 0.0 1.2 1 0 0 1 1 1 0 Kinase-like AP_endonuc_2 PF01261.24 EDO17757.1 - 3.9e-34 117.9 0.0 6e-34 117.3 0.0 1.3 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel GlutR_dimer PF00745.20 EDO17757.1 - 0.068 13.6 2.1 0.58 10.6 2.1 2.2 2 0 0 2 2 2 0 Glutamyl-tRNAGlu reductase, dimerisation domain HTH_51 PF18558.1 EDO17757.1 - 0.15 11.9 0.2 0.52 10.2 0.1 2.0 2 0 0 2 2 2 0 Helix-turn-helix domain XPG_N PF00752.17 EDO17758.1 - 1.9e-39 134.2 0.0 3.4e-39 133.4 0.0 1.5 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.18 EDO17758.1 - 5.1e-28 97.3 1.3 6.4e-28 96.9 0.0 1.8 2 0 0 2 2 2 1 XPG I-region 5_3_exonuc PF01367.20 EDO17758.1 - 8.2e-08 32.8 1.7 2.2e-06 28.2 0.0 2.8 3 0 0 3 3 3 1 5'-3' exonuclease, C-terminal SAM fold HHH_5 PF14520.6 EDO17758.1 - 0.0002 21.9 0.0 0.00099 19.7 0.0 2.2 1 0 0 1 1 1 1 Helix-hairpin-helix domain 5_3_exonuc_N PF02739.16 EDO17758.1 - 0.0058 16.5 0.1 0.018 15.0 0.1 1.8 1 1 0 1 1 1 1 5'-3' exonuclease, N-terminal resolvase-like domain HHH_2 PF12826.7 EDO17758.1 - 0.014 15.5 0.0 0.036 14.2 0.0 1.7 1 0 0 1 1 1 0 Helix-hairpin-helix motif Transposase_20 PF02371.16 EDO17758.1 - 0.022 15.0 0.1 0.28 11.5 0.0 2.4 2 0 0 2 2 2 0 Transposase IS116/IS110/IS902 family HIGH_NTase1 PF05636.11 EDO17759.1 - 0.0047 16.2 0.2 0.008 15.4 0.2 1.4 1 0 0 1 1 1 1 HIGH Nucleotidyl Transferase DUF2428 PF10350.9 EDO17760.1 - 1.3e-50 172.2 0.3 2.6e-50 171.2 0.3 1.5 1 0 0 1 1 1 1 Putative death-receptor fusion protein (DUF2428) HEAT PF02985.22 EDO17760.1 - 3.9e-05 23.5 0.2 0.54 10.7 0.0 4.9 4 0 0 4 4 4 1 HEAT repeat HEAT_2 PF13646.6 EDO17760.1 - 0.019 15.3 0.0 0.38 11.2 0.0 3.1 2 1 1 3 3 3 0 HEAT repeats SAP30_Sin3_bdg PF13867.6 EDO17761.1 - 3.4e-09 36.9 0.1 7.7e-05 22.9 0.0 2.4 2 0 0 2 2 2 2 Sin3 binding region of histone deacetylase complex subunit SAP30 DNA_pol3_a_NII PF11490.8 EDO17761.1 - 0.026 14.4 1.0 0.13 12.2 0.8 2.0 2 0 0 2 2 2 0 DNA polymerase III polC-type N-terminus II HAD_SAK_1 PF10307.9 EDO17762.1 - 2.2e-62 210.5 5.0 3.6e-62 209.8 5.0 1.4 1 0 0 1 1 1 1 HAD domain family 1 in Swiss Army Knife RNA repair proteins Fur_reg_FbpB PF13040.6 EDO17762.1 - 0.046 13.3 0.9 0.21 11.2 0.9 2.2 1 0 0 1 1 1 0 Fur-regulated basic protein B Nup188 PF10487.9 EDO17763.1 - 9.7e-248 824.7 56.8 9.7e-248 824.7 56.8 1.7 2 0 0 2 2 2 1 Nucleoporin subcomplex protein binding to Pom34 Nup188_C PF18378.1 EDO17763.1 - 6.2e-15 54.9 6.9 6.2e-15 54.9 6.9 2.1 2 0 0 2 2 2 1 Nuclear pore protein NUP188 C-terminal domain RRN9 PF10680.9 EDO17764.1 - 2.3e-14 53.4 0.2 8e-14 51.7 0.2 2.0 1 0 0 1 1 1 1 RNA polymerase I specific transcription initiation factor TPR_22 PF18833.1 EDO17764.1 - 0.088 13.0 1.9 0.18 11.9 0.1 2.5 2 1 0 2 2 2 0 Tetratricopeptide repeat Caveolin PF01146.17 EDO17764.1 - 0.14 12.1 0.1 0.26 11.3 0.1 1.4 1 0 0 1 1 1 0 Caveolin DUF2951 PF11166.8 EDO17764.1 - 4.7 7.5 11.6 39 4.6 4.2 3.8 3 1 1 4 4 4 0 Protein of unknown function (DUF2951) SRP19 PF01922.17 EDO17765.1 - 2.4e-30 105.3 0.1 8e-30 103.6 0.0 1.8 2 0 0 2 2 2 1 SRP19 protein FA_hydroxylase PF04116.13 EDO17766.1 - 8.7e-14 52.0 17.3 8.7e-14 52.0 17.3 1.9 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily Cyt-b5 PF00173.28 EDO17766.1 - 9.4e-10 38.5 1.7 1.2e-08 35.0 0.1 3.0 3 0 0 3 3 3 1 Cytochrome b5-like Heme/Steroid binding domain Anth_synt_I_N PF04715.13 EDO17766.1 - 0.01 16.1 0.1 0.024 14.9 0.1 1.5 1 0 0 1 1 1 0 Anthranilate synthase component I, N terminal region Zds_C PF08632.10 EDO17767.1 - 1.5e-28 98.2 1.7 2.9e-28 97.4 1.7 1.5 1 0 0 1 1 1 1 Activator of mitotic machinery Cdc14 phosphatase activation C-term Ubie_methyltran PF01209.18 EDO17768.1 - 8.7e-100 332.8 0.2 1.1e-99 332.6 0.2 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.6 EDO17768.1 - 3e-12 47.1 0.0 5.7e-12 46.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDO17768.1 - 1.3e-10 41.2 0.0 1.9e-10 40.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EDO17768.1 - 1.7e-10 41.4 0.0 3.8e-10 40.3 0.0 1.6 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EDO17768.1 - 3e-09 37.5 0.0 6e-09 36.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EDO17768.1 - 4.3e-06 26.7 0.0 6.4e-06 26.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain FAM104 PF15434.6 EDO17768.1 - 0.0029 18.1 2.8 0.0063 17.1 2.8 1.5 1 0 0 1 1 1 1 Family 104 Methyltransf_8 PF05148.15 EDO17768.1 - 0.008 16.0 0.0 0.32 10.8 0.0 2.3 1 1 1 2 2 2 1 Hypothetical methyltransferase Methyltransf_28 PF02636.17 EDO17768.1 - 0.0093 15.6 0.0 0.016 14.8 0.0 1.4 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase SR-25 PF10500.9 EDO17768.1 - 0.24 11.0 9.7 0.34 10.5 9.7 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF755 PF05501.11 EDO17768.1 - 4.9 7.4 15.6 8.2 6.7 15.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF755) Bul1_N PF04425.12 EDO17769.1 - 8e-172 572.0 5.2 8e-172 572.0 5.2 2.8 2 2 3 5 5 5 1 Bul1 N terminus Bul1_C PF04426.12 EDO17769.1 - 2.2e-115 384.8 14.8 2.2e-115 384.8 14.8 2.7 4 0 0 4 4 4 1 Bul1 C terminus DpnI_C PF17726.1 EDO17769.1 - 0.075 13.2 0.4 0.27 11.4 0.4 1.9 1 0 0 1 1 1 0 Dam-replacing HTH domain DUF2545 PF10810.8 EDO17769.1 - 0.15 12.2 0.0 0.3 11.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2545) CTK3_C PF12350.8 EDO17770.1 - 2e-17 63.1 2.2 2e-17 63.1 2.2 1.9 2 0 0 2 2 2 1 CTD kinase subunit gamma CTK3 C-terminus CTK3 PF12243.8 EDO17770.1 - 3.9e-06 26.9 0.6 0.0011 19.0 0.6 2.6 1 1 0 1 1 1 1 CTD kinase subunit gamma CTK3 Anp1 PF03452.14 EDO17772.1 - 5.7e-122 406.2 0.0 8.1e-122 405.7 0.0 1.2 1 0 0 1 1 1 1 Anp1 MFS_1 PF07690.16 EDO17773.1 - 1.2e-38 133.0 50.0 1.7e-37 129.2 50.0 2.5 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EDO17773.1 - 2.2e-05 23.5 3.0 2.2e-05 23.5 3.0 3.2 1 1 1 3 3 3 2 Sugar (and other) transporter FeoB_associated PF12669.7 EDO17773.1 - 1 9.8 0.0 1 9.8 0.0 3.7 3 0 0 3 3 3 0 FeoB-associated Cys-rich membrane protein Pyr_redox_2 PF07992.14 EDO17774.1 - 3.8e-48 164.2 0.0 4.8e-48 163.9 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EDO17774.1 - 3.8e-11 43.4 0.1 1.6e-08 35.0 0.2 3.2 2 2 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EDO17774.1 - 3.6e-06 26.4 0.8 0.23 10.7 0.1 3.3 3 0 0 3 3 3 3 Pyridine nucleotide-disulphide oxidoreductase DUF1451 PF07295.11 EDO17774.1 - 0.017 15.1 0.0 0.032 14.3 0.0 1.3 1 0 0 1 1 1 0 Zinc-ribbon containing domain Mesothelin PF06060.12 EDO17774.1 - 0.12 10.5 0.0 0.19 9.9 0.0 1.2 1 0 0 1 1 1 0 Pre-pro-megakaryocyte potentiating factor precursor (Mesothelin) Gtr1_RagA PF04670.12 EDO17775.1 - 8.3e-92 306.7 4.2 1.2e-91 306.2 4.2 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Ras PF00071.22 EDO17775.1 - 3e-09 36.7 0.5 1.1e-08 34.8 0.1 1.9 2 0 0 2 2 2 1 Ras family Roc PF08477.13 EDO17775.1 - 1.9e-08 34.6 0.4 4.9e-08 33.2 0.1 1.9 2 1 1 3 3 3 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EDO17775.1 - 8.6e-08 31.8 1.0 1.4e-07 31.2 0.1 1.8 2 0 0 2 2 2 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EDO17775.1 - 1.5e-07 31.5 0.1 4.1e-07 30.1 0.0 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase ABC_tran PF00005.27 EDO17775.1 - 0.0017 18.9 0.8 0.029 14.9 0.1 2.4 2 1 0 2 2 2 1 ABC transporter Guanylate_kin PF00625.21 EDO17775.1 - 0.0041 16.8 2.4 0.027 14.1 0.5 2.8 2 2 0 2 2 2 1 Guanylate kinase Runt PF00853.19 EDO17775.1 - 0.0048 16.4 1.6 0.16 11.6 0.1 2.8 3 0 0 3 3 3 1 Runt domain Fer2_3 PF13085.6 EDO17775.1 - 0.022 14.8 1.1 4.4 7.3 1.1 2.4 1 1 0 1 1 1 0 2Fe-2S iron-sulfur cluster binding domain DUF815 PF05673.13 EDO17775.1 - 0.044 13.0 0.0 0.099 11.8 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_29 PF13555.6 EDO17775.1 - 0.044 13.5 0.6 0.13 12.0 0.5 1.8 2 0 0 2 2 2 0 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EDO17775.1 - 0.1 12.5 4.5 1.1 9.1 0.1 2.9 3 0 0 3 3 3 0 RsgA GTPase TBCC_N PF16752.5 EDO17775.1 - 5.5 7.5 7.5 7.4 7.1 0.7 3.1 2 1 0 2 2 2 0 Tubulin-specific chaperone C N-terminal domain SQS_PSY PF00494.19 EDO17776.1 - 7.7e-40 137.1 0.0 9.4e-40 136.8 0.0 1.1 1 0 0 1 1 1 1 Squalene/phytoene synthase Sugar_tr PF00083.24 EDO17777.1 - 2.4e-44 152.0 16.2 2.9e-44 151.7 16.2 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDO17777.1 - 9.5e-26 90.5 28.9 2.1e-21 76.2 15.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily BRI3BP PF14965.6 EDO17777.1 - 0.78 9.2 3.0 0.62 9.6 0.8 1.9 2 0 0 2 2 2 0 Negative regulator of p53/TP53 Tubulin PF00091.25 EDO17778.1 - 7.4e-67 225.4 0.0 1.2e-66 224.7 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EDO17778.1 - 2e-50 170.1 0.4 3.2e-50 169.5 0.4 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain MSP PF01716.18 EDO17778.1 - 0.12 11.5 0.1 0.2 10.8 0.1 1.3 1 0 0 1 1 1 0 Manganese-stabilising protein / photosystem II polypeptide HMG_CoA_synt_C PF08540.10 EDO17779.1 - 4.5e-108 361.1 3.8 5.5e-108 360.8 3.8 1.1 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase C terminal HMG_CoA_synt_N PF01154.17 EDO17779.1 - 1.3e-94 315.0 0.3 1.9e-94 314.4 0.3 1.2 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase N terminal RPM2 PF08579.11 EDO17780.1 - 6.9e-40 136.2 7.0 6.9e-40 136.2 7.0 5.8 6 2 1 7 7 7 1 Mitochondrial ribonuclease P subunit (RPM2) PA28_alpha PF02251.18 EDO17780.1 - 0.083 12.9 0.0 0.083 12.9 0.0 3.3 4 0 0 4 4 4 0 Proteasome activator pa28 alpha subunit Ish1 PF10281.9 EDO17782.1 - 3.3e-38 129.7 24.2 1.6e-09 37.9 1.7 6.0 5 0 0 5 5 5 5 Putative stress-responsive nuclear envelope protein SAP PF02037.27 EDO17782.1 - 0.00072 19.2 0.0 0.56 10.0 0.0 3.7 4 0 0 4 4 4 1 SAP domain Slx4 PF09494.10 EDO17782.1 - 0.0099 15.8 0.2 40 4.3 0.1 4.9 4 1 0 4 4 4 0 Slx4 endonuclease Sep15_SelM PF08806.11 EDO17782.1 - 0.02 15.0 3.9 9.8 6.4 0.0 4.1 4 1 0 4 4 4 0 Sep15/SelM redox domain SAM_2 PF07647.17 EDO17782.1 - 0.03 14.4 2.9 37 4.5 0.1 4.6 4 0 0 4 4 4 0 SAM domain (Sterile alpha motif) SAP30_Sin3_bdg PF13867.6 EDO17782.1 - 0.03 14.7 0.1 3.3 8.1 0.0 3.2 3 0 0 3 3 3 0 Sin3 binding region of histone deacetylase complex subunit SAP30 GP52 PF17468.2 EDO17782.1 - 0.045 13.9 0.8 59 3.9 0.0 4.4 4 0 0 4 4 4 0 Phage gene product 52 DUF1192 PF06698.11 EDO17782.1 - 0.093 12.8 1.2 48 4.1 0.0 4.0 5 0 0 5 5 5 0 Protein of unknown function (DUF1192) Ish1 PF10281.9 EDO17783.1 - 2.2e-22 79.0 25.0 9.8e-06 25.8 1.2 6.5 6 0 0 6 6 6 5 Putative stress-responsive nuclear envelope protein Herpes_ori_bp PF02399.15 EDO17783.1 - 0.06 11.4 2.8 2.7 5.9 0.1 2.1 2 0 0 2 2 2 0 Origin of replication binding protein YdaT_toxin PF06254.11 EDO17783.1 - 0.12 12.9 0.2 23 5.7 0.0 2.6 2 0 0 2 2 2 0 Putative bacterial toxin ydaT Endonuc-dimeris PF09124.10 EDO17783.1 - 0.99 9.6 0.0 0.99 9.6 0.0 2.7 3 0 0 3 3 3 0 T4 recombination endonuclease VII, dimerisation Elf1 PF05129.13 EDO17784.1 - 0.16 12.1 3.3 2.3 8.3 0.4 2.8 3 0 0 3 3 3 0 Transcription elongation factor Elf1 like DUF2663 PF10864.8 EDO17785.1 - 0.24 11.8 7.1 0.18 12.2 0.4 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2663) SHR3_chaperone PF08229.11 EDO17785.1 - 0.97 8.4 6.5 1.4 7.9 4.8 1.9 2 0 0 2 2 2 0 ER membrane protein SH3 CrgA PF06781.12 EDO17785.1 - 5.7 7.1 7.0 12 6.0 0.2 2.8 3 0 0 3 3 3 0 Cell division protein CrgA Ribosomal_S25 PF03297.15 EDO17786.1 - 6.9e-39 132.1 8.6 7.7e-39 132.0 8.6 1.0 1 0 0 1 1 1 1 S25 ribosomal protein FtsK_gamma PF09397.10 EDO17786.1 - 0.00061 19.5 0.1 0.00092 19.0 0.1 1.3 1 0 0 1 1 1 1 Ftsk gamma domain HTH_CodY PF08222.11 EDO17786.1 - 0.025 14.1 0.3 0.037 13.6 0.3 1.3 1 0 0 1 1 1 0 CodY helix-turn-helix domain EAP30 PF04157.16 EDO17786.1 - 0.033 13.5 0.0 0.041 13.2 0.0 1.1 1 0 0 1 1 1 0 EAP30/Vps36 family HTH_DeoR PF08220.12 EDO17786.1 - 0.089 12.6 0.0 0.14 12.0 0.0 1.3 1 0 0 1 1 1 0 DeoR-like helix-turn-helix domain HTH_24 PF13412.6 EDO17786.1 - 0.12 12.0 0.1 0.17 11.5 0.1 1.3 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding Copper-fist PF00649.18 EDO17787.1 - 1.2e-21 75.9 0.6 2.2e-21 75.0 0.6 1.5 1 0 0 1 1 1 1 Copper fist DNA binding domain zinc-ribbons_6 PF07191.12 EDO17787.1 - 0.076 13.0 0.4 0.14 12.1 0.4 1.5 1 0 0 1 1 1 0 zinc-ribbons SNF2_N PF00176.23 EDO17788.1 - 1.9e-56 191.3 0.0 2.9e-56 190.7 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Rad54_N PF08658.10 EDO17788.1 - 1.1e-40 139.8 3.8 1.1e-40 139.8 3.8 3.1 3 0 0 3 3 3 1 Rad54 N terminal Helicase_C PF00271.31 EDO17788.1 - 3.8e-17 62.6 0.0 9.5e-17 61.4 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDO17788.1 - 1.2e-07 31.9 0.0 8.5e-07 29.1 0.0 2.4 2 1 1 3 3 3 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 EDO17788.1 - 4.8e-05 22.7 0.0 4.8e-05 22.7 0.0 3.6 4 1 0 4 4 4 1 Class II histone deacetylase complex subunits 2 and 3 PIEZO PF15917.5 EDO17788.1 - 2.2 7.7 13.1 3.6 7.0 3.0 2.3 2 0 0 2 2 2 0 Piezo RNA_pol_Rpc4 PF05132.14 EDO17788.1 - 5.6 7.4 9.4 1.6 9.1 1.6 2.3 2 0 0 2 2 2 0 RNA polymerase III RPC4 RP-C_C PF11800.8 EDO17788.1 - 9.9 6.2 6.8 2.1 8.4 0.4 2.2 2 0 0 2 2 2 0 Replication protein C C-terminal region dCMP_cyt_deam_1 PF00383.23 EDO17789.1 - 2.4e-13 49.8 0.2 4e-13 49.1 0.2 1.3 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region dCMP_cyt_deam_2 PF08211.12 EDO17789.1 - 4.9e-09 36.5 0.0 1e-07 32.2 0.0 2.1 2 0 0 2 2 2 1 Cytidine and deoxycytidylate deaminase zinc-binding region LmjF365940-deam PF14421.6 EDO17789.1 - 3.8e-06 26.7 0.4 0.0031 17.2 0.1 2.1 1 1 1 2 2 2 2 A distinct subfamily of CDD/CDA-like deaminases Zn_clus PF00172.18 EDO17790.1 - 0.00034 20.7 6.4 0.0023 18.0 1.3 2.5 2 0 0 2 2 2 2 Fungal Zn(2)-Cys(6) binuclear cluster domain Sua5_yciO_yrdC PF01300.18 EDO17792.1 - 1.7e-46 157.9 0.0 2.8e-46 157.2 0.0 1.3 1 0 0 1 1 1 1 Telomere recombination SUA5 PF03481.13 EDO17792.1 - 1.2e-30 106.8 0.0 1.7e-30 106.3 0.0 1.3 1 0 0 1 1 1 1 Putative GTP-binding controlling metal-binding Mucin15 PF15672.5 EDO17792.1 - 0.047 13.2 2.3 2.9 7.3 0.1 2.2 2 0 0 2 2 2 0 Cell-membrane associated Mucin15 E1-E2_ATPase PF00122.20 EDO17793.1 - 3.2e-49 166.9 0.0 3.2e-49 166.9 0.0 2.3 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 EDO17793.1 - 7.7e-47 159.4 2.8 7.7e-47 159.4 2.8 2.3 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 EDO17793.1 - 3.7e-21 76.4 0.6 2e-20 74.0 0.6 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EDO17793.1 - 1.4e-17 63.5 0.1 2.9e-17 62.5 0.1 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 EDO17793.1 - 2.2e-13 49.7 0.0 5.5e-13 48.4 0.0 1.7 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 EDO17793.1 - 0.0012 18.7 6.0 0.0033 17.2 0.5 2.8 3 0 0 3 3 3 1 haloacid dehalogenase-like hydrolase RseC_MucC PF04246.12 EDO17793.1 - 0.14 12.1 0.0 0.52 10.3 0.0 1.9 1 0 0 1 1 1 0 Positive regulator of sigma(E), RseC/MucC DUF3784 PF12650.7 EDO17793.1 - 1.5 9.0 8.6 11 6.4 0.8 3.6 3 0 0 3 3 3 0 Domain of unknown function (DUF3784) SPC12 PF06645.13 EDO17793.1 - 2.7 8.2 5.2 0.98 9.5 0.9 2.6 2 0 0 2 2 2 0 Microsomal signal peptidase 12 kDa subunit (SPC12) RNA_pol_Rpb2_6 PF00562.28 EDO17794.1 - 6.1e-115 384.4 0.0 1.4e-114 383.2 0.0 1.6 1 1 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 EDO17794.1 - 1.8e-44 151.7 0.1 2.6e-44 151.2 0.1 1.2 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_2 PF04561.14 EDO17794.1 - 4.4e-37 127.6 0.0 9.4e-37 126.5 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_3 PF04565.16 EDO17794.1 - 2.6e-28 98.0 0.0 1.5e-27 95.5 0.0 2.4 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpa2_4 PF06883.12 EDO17794.1 - 8.9e-24 83.3 0.0 1.8e-23 82.3 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase I, Rpa2 specific domain RNA_pol_Rpb2_7 PF04560.20 EDO17794.1 - 8.1e-16 58.2 0.0 2.7e-14 53.3 0.0 2.6 1 1 0 1 1 1 1 RNA polymerase Rpb2, domain 7 B12D PF06522.11 EDO17795.1 - 0.0014 18.4 0.0 0.0017 18.1 0.0 1.2 1 0 0 1 1 1 1 NADH-ubiquinone reductase complex 1 MLRQ subunit Mito_carr PF00153.27 EDO17796.1 - 2.2e-67 223.0 0.6 4e-22 77.9 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF3792 PF12670.7 EDO17796.1 - 0.38 10.9 4.3 9.3 6.5 0.2 3.4 2 2 2 4 4 4 0 Protein of unknown function (DUF3792) zf-C2H2 PF00096.26 EDO17797.1 - 1.3e-08 34.8 10.9 0.00013 22.2 0.8 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EDO17797.1 - 8e-06 26.0 0.4 8e-06 26.0 0.4 3.0 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 EDO17797.1 - 1.5e-05 25.4 10.4 0.0043 17.8 0.9 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger PI3K_1B_p101 PF10486.9 EDO17797.1 - 0.002 16.0 12.4 0.0025 15.7 12.4 1.1 1 0 0 1 1 1 1 Phosphoinositide 3-kinase gamma adapter protein p101 subunit zf-met PF12874.7 EDO17797.1 - 0.013 15.8 1.5 0.013 15.8 1.5 3.1 3 0 0 3 3 3 0 Zinc-finger of C2H2 type DUF2284 PF10050.9 EDO17797.1 - 0.039 13.7 0.9 0.064 13.0 0.3 1.7 1 1 0 1 1 1 0 Predicted metal-binding protein (DUF2284) Fer4_16 PF13484.6 EDO17797.1 - 0.37 11.8 4.9 0.55 11.2 0.2 2.9 2 0 0 2 2 2 0 4Fe-4S double cluster binding domain zf-C2H2_jaz PF12171.8 EDO17797.1 - 0.75 10.2 12.6 0.67 10.3 0.8 3.2 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding Macoilin PF09726.9 EDO17797.1 - 0.95 7.9 23.6 1.1 7.7 23.6 1.2 1 0 0 1 1 1 0 Macoilin family XRN_N PF03159.18 EDO17798.1 - 7.7e-96 320.2 0.2 7.7e-96 320.2 0.2 2.2 3 0 0 3 3 3 1 XRN 5'-3' exonuclease N-terminus XRN_M PF17846.1 EDO17798.1 - 3.1e-77 260.4 22.5 2.9e-59 201.2 0.5 3.8 3 0 0 3 3 3 2 Xrn1 helical domain XRN1_D1 PF18332.1 EDO17798.1 - 2.5e-64 216.6 0.8 2.5e-64 216.6 0.8 2.5 3 0 0 3 3 3 1 Exoribonuclease Xrn1 D1 domain XRN1_D2_D3 PF18334.1 EDO17798.1 - 2.9e-29 101.1 1.9 4.2e-29 100.6 0.0 2.4 2 0 0 2 2 2 1 Exoribonuclease Xrn1 D2/D3 domain Xrn1_D3 PF18194.1 EDO17798.1 - 7.1e-23 80.5 0.7 1.9e-22 79.1 0.7 1.8 1 0 0 1 1 1 1 Exoribonuclease 1 Domain-3 SH3_12 PF18129.1 EDO17798.1 - 3.5e-20 71.9 0.3 7.2e-20 70.9 0.3 1.6 1 0 0 1 1 1 1 Xrn1 SH3-like domain Bud13 PF09736.9 EDO17799.1 - 1e-23 84.3 12.6 1e-23 84.3 12.6 3.3 2 2 0 2 2 2 1 Pre-mRNA-splicing factor of RES complex IRK_C PF17655.1 EDO17801.1 - 0.011 15.4 0.2 0.043 13.4 0.0 1.9 2 0 0 2 2 2 0 Inward rectifier potassium channel C-terminal domain PUF PF00806.19 EDO17802.1 - 4e-50 164.8 29.1 1.9e-06 27.2 0.5 8.8 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat Ribosomal_S8e PF01201.22 EDO17803.1 - 3.7e-46 156.7 0.0 6.5e-46 155.9 0.0 1.3 1 1 0 1 1 1 1 Ribosomal protein S8e DUF3746 PF12562.8 EDO17803.1 - 0.12 12.3 0.2 0.28 11.1 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3746) Sas10_Utp3 PF04000.15 EDO17804.1 - 8e-13 48.8 1.4 8e-13 48.8 1.4 2.4 2 1 1 3 3 3 1 Sas10/Utp3/C1D family CDV3 PF15359.6 EDO17804.1 - 0.064 13.7 10.0 0.14 12.6 9.3 1.9 1 1 0 1 1 1 0 Carnitine deficiency-associated protein 3 Hid1 PF12722.7 EDO17804.1 - 0.78 7.8 10.7 1.2 7.1 10.7 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein NOA36 PF06524.12 EDO17804.1 - 0.97 8.7 14.3 2.2 7.5 14.3 1.5 1 0 0 1 1 1 0 NOA36 protein Vfa1 PF08432.10 EDO17805.1 - 1.1e-38 133.4 12.2 1.3e-38 133.2 12.2 1.0 1 0 0 1 1 1 1 AAA-ATPase Vps4-associated protein 1 Atg14 PF10186.9 EDO17805.1 - 0.014 14.5 7.2 0.017 14.3 7.2 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF4326 PF14216.6 EDO17805.1 - 0.067 13.9 1.7 4.4 8.1 1.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4326) DUF664 PF04978.12 EDO17805.1 - 0.09 13.2 0.4 0.15 12.4 0.3 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF664) CRA PF06589.11 EDO17805.1 - 0.1 12.7 16.7 0.069 13.3 15.1 1.5 1 1 0 1 1 1 0 Circumsporozoite-related antigen (CRA) DUF4407 PF14362.6 EDO17805.1 - 0.64 9.3 5.9 0.85 8.9 5.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) LMBR1 PF04791.16 EDO17805.1 - 0.68 8.8 10.8 0.82 8.5 10.8 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein GLTSCR1 PF15249.6 EDO17805.1 - 1.1 9.7 8.6 2.4 8.6 8.6 1.6 1 0 0 1 1 1 0 Conserved region of unknown function on GLTSCR protein Mis14 PF08641.12 EDO17805.1 - 1.3 9.3 15.8 0.25 11.6 10.0 2.4 2 1 0 2 2 2 0 Kinetochore protein Mis14 like FapA PF03961.13 EDO17805.1 - 3.2 6.2 12.2 4.1 5.9 12.2 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A DUF3450 PF11932.8 EDO17805.1 - 9.5 5.4 15.1 1.6 8.0 11.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) DUF3543 PF12063.8 EDO17806.1 - 1.3e-85 286.8 5.5 1.3e-85 286.8 5.5 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF3543) Pkinase PF00069.25 EDO17806.1 - 2.3e-56 191.1 0.6 2.1e-54 184.7 0.1 2.7 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EDO17806.1 - 3e-42 144.7 0.0 7.2e-42 143.5 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase UN_NPL4 PF11543.8 EDO17806.1 - 0.073 13.6 0.6 0.63 10.6 0.1 3.0 3 0 0 3 3 3 0 Nuclear pore localisation protein NPL4 MIT PF04212.18 EDO17806.1 - 0.13 12.3 2.4 35 4.5 0.0 3.9 2 2 0 2 2 2 0 MIT (microtubule interacting and transport) domain ArfGap PF01412.18 EDO17807.1 - 2.8e-30 104.8 0.0 2.8e-30 104.8 0.0 2.8 3 0 0 3 3 3 1 Putative GTPase activating protein for Arf DUF987 PF06174.11 EDO17807.1 - 0.0092 15.9 0.3 0.35 10.8 0.1 2.7 2 0 0 2 2 2 1 Protein of unknown function (DUF987) Med15 PF09606.10 EDO17807.1 - 1.3 7.6 65.7 1.7 7.2 65.7 1.2 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal LMBR1 PF04791.16 EDO17807.1 - 2 7.2 4.6 2.1 7.1 4.6 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein Mnd1 PF03962.15 EDO17808.1 - 3e-20 72.2 0.4 3e-20 72.2 0.4 2.4 3 0 0 3 3 3 1 Mnd1 HTH domain LZ3wCH PF18517.1 EDO17808.1 - 9e-06 25.7 0.3 9e-06 25.7 0.3 2.6 3 1 0 3 3 3 1 Leucine zipper with capping helix domain DUF2408 PF10303.9 EDO17808.1 - 0.64 10.6 9.0 3.3 8.3 0.4 2.2 1 1 0 2 2 2 0 Protein of unknown function (DUF2408) Pre-PUA PF17832.1 EDO17808.1 - 7.4 7.3 8.9 2.3 9.0 1.7 3.0 1 1 1 3 3 3 0 Pre-PUA-like domain 2-Hacid_dh_C PF02826.19 EDO17809.1 - 3.9e-30 104.5 0.0 6.3e-30 103.8 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EDO17809.1 - 1.2e-06 28.3 0.0 2.1e-05 24.2 0.0 2.5 2 1 0 3 3 3 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain ApbA PF02558.16 EDO17809.1 - 0.16 11.6 0.0 0.46 10.1 0.0 1.7 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA Transp_cyt_pur PF02133.15 EDO17810.1 - 5.5e-16 58.4 24.2 5.5e-16 58.4 24.2 1.8 2 0 0 2 2 2 1 Permease for cytosine/purines, uracil, thiamine, allantoin Nramp PF01566.18 EDO17810.1 - 0.13 11.2 21.0 0.33 9.9 10.0 2.4 2 0 0 2 2 2 0 Natural resistance-associated macrophage protein Macro_2 PF14519.6 EDO17812.1 - 9.1e-149 494.3 0.1 1e-148 494.2 0.1 1.0 1 0 0 1 1 1 1 Macro-like domain Macro PF01661.21 EDO17812.1 - 0.0014 18.7 0.0 0.0023 18.0 0.0 1.4 1 0 0 1 1 1 1 Macro domain Ribophorin_II PF05817.14 EDO17813.1 - 9.4e-17 60.8 1.3 1.2e-16 60.5 1.3 1.2 1 0 0 1 1 1 1 Oligosaccharyltransferase subunit Ribophorin II DUF5455 PF17537.2 EDO17813.1 - 0.11 12.9 0.5 0.11 12.9 0.5 2.2 1 1 1 2 2 2 0 Family of unknown function (DUF5455) ETRAMP PF09716.10 EDO17813.1 - 0.27 11.3 0.1 0.27 11.3 0.1 2.5 3 0 0 3 3 3 0 Malarial early transcribed membrane protein (ETRAMP) Peptidase_S24 PF00717.23 EDO17814.1 - 9e-05 22.4 0.1 0.00068 19.5 0.0 2.4 2 2 0 2 2 2 1 Peptidase S24-like Peptidase_S26 PF10502.9 EDO17814.1 - 0.0022 17.8 0.0 0.0083 15.9 0.0 1.9 1 1 0 1 1 1 1 Signal peptidase, peptidase S26 adh_short PF00106.25 EDO17815.1 - 3.9e-08 33.0 0.0 5.6e-08 32.5 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase LUC7 PF03194.15 EDO17816.1 - 1.7e-54 185.1 4.2 2.1e-54 184.8 4.2 1.1 1 0 0 1 1 1 1 LUC7 N_terminus Seryl_tRNA_N PF02403.22 EDO17816.1 - 1.4 9.1 8.0 0.66 10.2 0.2 2.9 2 1 1 3 3 3 0 Seryl-tRNA synthetase N-terminal domain Nup35_RRM PF05172.13 EDO17817.1 - 2.7e-36 123.6 0.0 5.9e-36 122.5 0.0 1.5 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif Nup35_RRM_2 PF14605.6 EDO17817.1 - 0.019 15.0 0.0 0.052 13.6 0.0 1.8 1 1 0 1 1 1 0 Nup53/35/40-type RNA recognition motif Prenyltrans PF00432.21 EDO17818.1 - 2.4e-44 148.8 11.3 1.2e-13 50.5 0.2 6.7 6 1 1 7 7 7 5 Prenyltransferase and squalene oxidase repeat SQHop_cyclase_C PF13243.6 EDO17818.1 - 0.0053 15.9 0.0 0.42 9.7 0.0 2.2 1 1 1 2 2 2 2 Squalene-hopene cyclase C-terminal domain Crl PF07417.12 EDO17818.1 - 0.015 15.3 0.0 0.033 14.2 0.0 1.5 1 0 0 1 1 1 0 Sigma factor-binding transcriptional regulator Crl GCIP PF13324.6 EDO17818.1 - 0.072 12.7 2.7 0.18 11.4 2.7 1.6 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting SRP14 PF02290.15 EDO17819.1 - 4.7e-27 94.2 0.1 7.2e-27 93.6 0.1 1.3 1 0 0 1 1 1 1 Signal recognition particle 14kD protein MFS_1 PF07690.16 EDO17820.1 - 7.5e-14 51.4 15.6 1.7e-13 50.2 15.4 1.7 1 1 0 1 1 1 1 Major Facilitator Superfamily Nodulin-like PF06813.13 EDO17820.1 - 6.3e-12 45.5 5.1 6.3e-12 45.5 5.1 1.9 2 0 0 2 2 2 1 Nodulin-like PMT PF02366.18 EDO17821.1 - 4.9e-83 278.5 21.3 4.9e-83 278.5 21.3 1.9 2 0 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 EDO17821.1 - 4e-59 199.6 24.6 4e-59 199.6 24.6 2.4 2 1 0 2 2 2 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 EDO17821.1 - 2.6e-44 151.3 0.5 4.2e-44 150.6 0.5 1.3 1 0 0 1 1 1 1 MIR domain 2OG-Fe_Oxy_2 PF10014.9 EDO17822.1 - 0.052 13.3 0.0 0.078 12.8 0.0 1.3 1 0 0 1 1 1 0 2OG-Fe dioxygenase Ribosomal_S8 PF00410.19 EDO17823.1 - 4.2e-15 55.8 0.0 2.7e-14 53.2 0.0 1.8 1 1 0 1 1 1 1 Ribosomal protein S8 ATG16 PF08614.11 EDO17824.1 - 1.4e-11 45.0 12.8 2.9e-11 44.0 11.7 1.8 2 0 0 2 2 2 1 Autophagy protein 16 (ATG16) Fez1 PF06818.15 EDO17824.1 - 0.0013 19.2 4.5 0.0015 19.1 4.5 1.1 1 0 0 1 1 1 1 Fez1 HAP1_N PF04849.13 EDO17824.1 - 0.0016 17.7 6.9 0.002 17.4 6.9 1.2 1 0 0 1 1 1 1 HAP1 N-terminal conserved region Herpes_BLRF2 PF05812.12 EDO17824.1 - 0.033 14.3 1.2 0.063 13.4 1.2 1.5 1 0 0 1 1 1 0 Herpesvirus BLRF2 protein NUDE_C PF04880.13 EDO17824.1 - 0.04 14.4 11.2 0.047 14.2 11.2 1.1 1 0 0 1 1 1 0 NUDE protein, C-terminal conserved region LIG3_BRCT PF16759.5 EDO17824.1 - 0.047 14.0 0.0 0.077 13.3 0.0 1.4 1 0 0 1 1 1 0 DNA ligase 3 BRCT domain KLRAQ PF10205.9 EDO17824.1 - 0.07 13.4 6.1 0.12 12.6 6.1 1.4 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein zf-CRD PF17979.1 EDO17824.1 - 0.073 13.2 1.4 0.08 13.0 1.4 1.3 1 1 0 1 1 1 0 Cysteine rich domain with multizinc binding regions TolA_bind_tri PF16331.5 EDO17824.1 - 0.14 12.3 7.1 0.36 10.9 7.1 1.7 1 1 0 1 1 1 0 TolA binding protein trimerisation V_ATPase_I PF01496.19 EDO17824.1 - 0.3 8.9 3.6 0.31 8.9 3.6 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family HIP1_clath_bdg PF16515.5 EDO17824.1 - 0.44 11.2 7.1 0.079 13.6 1.0 2.0 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 SlyX PF04102.12 EDO17824.1 - 0.55 10.9 4.4 1.5 9.5 4.4 1.8 1 1 0 1 1 1 0 SlyX UDPGP PF01704.18 EDO17826.1 - 4.9e-47 160.5 0.0 6.5e-47 160.1 0.0 1.1 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase NTP_transferase PF00483.23 EDO17826.1 - 0.13 11.8 0.0 0.25 10.9 0.0 1.5 1 0 0 1 1 1 0 Nucleotidyl transferase Vezatin PF12632.7 EDO17827.1 - 3.8e-06 26.5 19.9 9.2e-06 25.2 19.9 1.6 1 0 0 1 1 1 1 Mysoin-binding motif of peroxisomes LisH PF08513.11 EDO17828.1 - 1.4e-05 24.8 1.5 2.9e-05 23.9 1.5 1.5 1 0 0 1 1 1 1 LisH LNS2 PF08235.13 EDO17829.1 - 1.4e-95 319.1 0.0 2.7e-95 318.1 0.0 1.5 1 1 0 1 1 1 1 LNS2 (Lipin/Ned1/Smp2) Lipin_N PF04571.14 EDO17829.1 - 1.4e-43 147.0 0.0 5.9e-43 145.0 0.0 2.1 2 0 0 2 2 2 1 lipin, N-terminal conserved region Mito_carr PF00153.27 EDO17830.1 - 1.3e-65 217.3 4.1 5e-23 80.8 0.1 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 EDO17830.1 - 0.017 14.3 0.4 2.8 7.0 0.1 2.3 2 0 0 2 2 2 0 Gammaproteobacterial serine protease DUF3823 PF12866.7 EDO17830.1 - 0.15 12.4 3.1 1.9 8.8 0.3 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF3823) N-terminal domain Peptidase_M22 PF00814.25 EDO17831.1 - 2.4e-69 234.1 0.0 2.7e-69 233.9 0.0 1.0 1 0 0 1 1 1 1 Glycoprotease family Mlh1_C PF16413.5 EDO17832.1 - 3.2e-84 282.5 2.6 5.7e-84 281.7 2.6 1.4 1 0 0 1 1 1 1 DNA mismatch repair protein Mlh1 C-terminus DNA_mis_repair PF01119.19 EDO17832.1 - 5.6e-28 97.0 3.4 1.5e-27 95.6 0.3 2.9 3 0 0 3 3 3 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.6 EDO17832.1 - 9e-12 45.0 1.4 1.6e-11 44.2 0.1 2.1 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 EDO17832.1 - 1.3e-06 28.9 0.0 5.4e-06 26.9 0.0 2.0 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Cep3 PF16846.5 EDO17833.1 - 1.4e-203 677.0 29.8 1.6e-203 676.8 29.8 1.0 1 0 0 1 1 1 1 Centromere DNA-binding protein complex CBF3 subunit B Zn_clus PF00172.18 EDO17833.1 - 1.9e-06 27.9 8.3 3.2e-06 27.2 8.3 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Bcr-Abl_Oligo PF09036.10 EDO17833.1 - 0.039 14.0 0.0 0.11 12.6 0.0 1.7 1 0 0 1 1 1 0 Bcr-Abl oncoprotein oligomerisation domain Homeodomain PF00046.29 EDO17834.1 - 1.1e-16 60.3 2.5 2e-16 59.5 2.5 1.4 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EDO17834.1 - 0.0021 17.9 0.2 0.0053 16.6 0.2 1.7 1 0 0 1 1 1 1 Homeobox KN domain SPRY PF00622.28 EDO17835.1 - 1.3e-11 44.7 0.0 2.8e-11 43.6 0.0 1.6 1 0 0 1 1 1 1 SPRY domain DUF4083 PF13314.6 EDO17835.1 - 2.1 8.4 7.3 3.7 7.6 7.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4083) RINT1_TIP1 PF04437.13 EDO17836.1 - 2.3e-69 234.6 30.8 2.3e-69 234.6 30.8 1.9 2 0 0 2 2 2 1 RINT-1 / TIP-1 family DUF3496 PF12001.8 EDO17836.1 - 8.7 6.8 9.3 0.51 10.7 0.2 3.3 4 0 0 4 4 4 0 Domain of unknown function (DUF3496) ORF6C PF10552.9 EDO17836.1 - 9.1 6.4 14.5 0.034 14.2 2.9 2.9 3 0 0 3 3 3 0 ORF6C domain SpoU_methylase PF00588.19 EDO17837.1 - 3.3e-26 92.2 0.0 9.3e-26 90.7 0.0 1.8 2 0 0 2 2 2 1 SpoU rRNA Methylase family PX PF00787.24 EDO17838.1 - 1.6e-23 82.8 0.3 1.5e-22 79.7 0.0 2.3 2 0 0 2 2 2 1 PX domain Vps5 PF09325.10 EDO17838.1 - 8.4e-05 22.2 25.3 9.3e-05 22.1 0.8 2.7 4 0 0 4 4 4 2 Vps5 C terminal like Dynein_C PF18199.1 EDO17838.1 - 0.03 13.5 1.7 0.065 12.4 1.7 1.5 1 0 0 1 1 1 0 Dynein heavy chain C-terminal domain Baculo_PEP_C PF04513.12 EDO17838.1 - 1.5 8.9 6.8 0.78 9.8 0.2 3.6 4 0 0 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus Nup84_Nup100 PF04121.13 EDO17839.1 - 8.1e-185 616.0 13.5 9.5e-185 615.8 13.5 1.0 1 0 0 1 1 1 1 Nuclear pore protein 84 / 107 TNFR_16_TM PF18422.1 EDO17839.1 - 0.067 13.2 1.0 7.2 6.7 0.2 2.4 2 0 0 2 2 2 0 Tumor necrosis factor receptor member 16 trans-membrane domain Chorismate_synt PF01264.21 EDO17840.1 - 3.2e-140 466.5 0.0 3.6e-140 466.3 0.0 1.0 1 0 0 1 1 1 1 Chorismate synthase GrpE PF01025.19 EDO17840.1 - 0.13 11.9 0.0 0.23 11.1 0.0 1.3 1 0 0 1 1 1 0 GrpE ACPS PF01648.20 EDO17841.1 - 1.9e-15 57.0 0.0 7.4e-15 55.1 0.0 1.8 2 0 0 2 2 2 1 4'-phosphopantetheinyl transferase superfamily Mito_carr PF00153.27 EDO17842.1 - 1e-52 176.0 4.3 8.2e-19 67.3 0.1 3.4 3 1 0 3 3 3 3 Mitochondrial carrier protein Frataxin_Cyay PF01491.16 EDO17843.1 - 2.7e-37 127.2 0.0 4.7e-37 126.4 0.0 1.3 1 0 0 1 1 1 1 Frataxin-like domain Helo_like_N PF17111.5 EDO17843.1 - 0.17 11.2 0.0 0.29 10.5 0.0 1.3 1 0 0 1 1 1 0 Fungal N-terminal domain of STAND proteins RRM_1 PF00076.22 EDO17844.1 - 1.6e-53 178.4 1.9 9.4e-19 67.0 0.2 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EDO17844.1 - 1e-08 34.9 0.0 0.012 15.4 0.0 3.0 3 0 0 3 3 3 2 Occluded RNA-recognition motif RRM_5 PF13893.6 EDO17844.1 - 5.8e-07 29.1 0.0 0.0013 18.3 0.0 2.8 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EDO17844.1 - 0.00027 21.0 1.2 0.43 10.7 0.1 3.8 3 2 0 4 4 4 2 RNA recognition motif Nup35_RRM_2 PF14605.6 EDO17844.1 - 0.004 17.1 0.1 0.1 12.6 0.0 2.6 3 0 0 3 3 3 1 Nup53/35/40-type RNA recognition motif Sds3 PF08598.11 EDO17845.1 - 4.8e-75 252.3 19.9 8.7e-75 251.5 19.9 1.4 1 1 0 1 1 1 1 Sds3-like DUF484 PF04340.12 EDO17845.1 - 0.061 13.0 2.7 0.11 12.2 2.7 1.5 1 1 0 1 1 1 0 Protein of unknown function, DUF484 Tim44 PF04280.15 EDO17845.1 - 0.08 13.0 0.3 0.16 12.0 0.3 1.5 1 0 0 1 1 1 0 Tim44-like domain Menin PF05053.13 EDO17845.1 - 3.6 5.8 9.2 5 5.4 9.2 1.3 1 0 0 1 1 1 0 Menin CENP-T_C PF15511.6 EDO17846.1 - 1.9e-09 37.6 0.1 2.2e-09 37.4 0.1 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold Histone PF00125.24 EDO17846.1 - 2.1e-05 24.9 0.1 2.5e-05 24.7 0.1 1.2 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TAF PF02969.17 EDO17846.1 - 3e-05 24.1 0.1 4.2e-05 23.6 0.1 1.3 1 0 0 1 1 1 1 TATA box binding protein associated factor (TAF) CBFD_NFYB_HMF PF00808.23 EDO17846.1 - 3.6e-05 24.0 0.1 6.1e-05 23.2 0.0 1.5 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-S PF15630.6 EDO17846.1 - 0.00017 21.9 0.1 0.00023 21.5 0.1 1.4 1 1 0 1 1 1 1 CENP-S protein TFIID-31kDa PF02291.15 EDO17846.1 - 0.0029 17.7 0.0 0.0035 17.4 0.0 1.1 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 EDO17846.1 - 0.0067 16.4 0.0 0.0096 15.9 0.0 1.2 1 0 0 1 1 1 1 Bromodomain associated TFIID_20kDa PF03847.13 EDO17846.1 - 0.043 14.3 0.0 0.072 13.6 0.0 1.4 1 0 0 1 1 1 0 Transcription initiation factor TFIID subunit A Histone PF00125.24 EDO17847.1 - 3.1e-49 166.7 3.4 3.4e-49 166.5 3.4 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.6 EDO17847.1 - 2e-06 28.1 0.0 3e-06 27.5 0.0 1.2 1 0 0 1 1 1 1 CENP-S protein PAF PF15715.5 EDO17847.1 - 5.5e-05 23.8 1.3 6.9e-05 23.5 1.3 1.2 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CENP-T_C PF15511.6 EDO17847.1 - 0.00011 22.3 0.8 0.00015 21.9 0.1 1.6 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold CBFD_NFYB_HMF PF00808.23 EDO17847.1 - 0.0018 18.5 0.9 0.0023 18.2 0.1 1.6 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 EDO17847.1 - 0.035 14.2 0.2 0.058 13.5 0.0 1.5 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit Aim19 PF10315.9 EDO17848.1 - 2.1e-36 124.7 1.2 2.5e-36 124.5 1.2 1.1 1 0 0 1 1 1 1 Altered inheritance of mitochondria protein 19 Tau95 PF09734.9 EDO17849.1 - 1.2e-36 126.6 0.4 1.2e-36 126.6 0.4 1.7 2 0 0 2 2 2 1 RNA polymerase III transcription factor (TF)IIIC subunit HTH domain Tau95_N PF17682.1 EDO17849.1 - 5.9e-23 81.5 0.1 1.3e-22 80.4 0.1 1.6 1 0 0 1 1 1 1 Tau95 Triple barrel domain Cwf_Cwc_15 PF04889.12 EDO17849.1 - 0.27 11.0 8.1 0.45 10.2 8.1 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein SSP160 PF06933.11 EDO17849.1 - 2.4 6.2 5.2 3.5 5.7 5.2 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 SDA1 PF05285.12 EDO17849.1 - 5.9 6.2 12.3 9.5 5.5 12.3 1.2 1 0 0 1 1 1 0 SDA1 Presenilin PF01080.17 EDO17849.1 - 7.3 5.2 5.6 12 4.6 5.6 1.2 1 0 0 1 1 1 0 Presenilin PP2C PF00481.21 EDO17850.1 - 2.7e-66 223.9 0.6 4.8e-61 206.6 0.2 2.4 1 1 1 2 2 2 2 Protein phosphatase 2C Glyco_transf_20 PF00982.21 EDO17851.1 - 6.4e-203 674.7 0.1 7.2e-203 674.5 0.1 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 20 Glyco_transf_5 PF08323.11 EDO17851.1 - 0.0013 18.5 0.1 0.0027 17.5 0.1 1.6 1 0 0 1 1 1 1 Starch synthase catalytic domain Glycos_transf_1 PF00534.20 EDO17851.1 - 0.0038 16.8 0.8 0.18 11.4 0.2 3.1 2 1 0 2 2 2 1 Glycosyl transferases group 1 RNB PF00773.19 EDO17852.1 - 3.2e-96 322.5 0.0 5.1e-96 321.8 0.0 1.3 1 0 0 1 1 1 1 RNB domain Rrp44_CSD1 PF17216.3 EDO17852.1 - 6.1e-64 214.2 0.4 2.6e-63 212.1 0.1 2.2 2 0 0 2 2 2 1 Rrp44-like cold shock domain Rrp44_S1 PF17215.3 EDO17852.1 - 7.3e-29 99.6 1.3 7.3e-29 99.6 1.3 2.2 2 0 0 2 2 2 1 S1 domain OB_Dis3 PF17849.1 EDO17852.1 - 4.1e-17 62.0 0.0 1.1e-16 60.6 0.0 1.8 1 0 0 1 1 1 1 Dis3-like cold-shock domain 2 (CSD2) PIN_4 PF13638.6 EDO17852.1 - 4.8e-15 56.0 0.6 1.1e-14 54.8 0.6 1.7 1 0 0 1 1 1 1 PIN domain CSD2 PF17876.1 EDO17852.1 - 5.3e-05 23.3 0.0 0.0062 16.7 0.0 3.0 2 0 0 2 2 2 1 Cold shock domain Dis3l2_C_term PF17877.1 EDO17852.1 - 0.014 15.7 0.2 0.014 15.7 0.2 1.9 2 0 0 2 2 2 0 DIS3-like exonuclease 2 C terminal OB_RNB PF08206.11 EDO17852.1 - 0.048 13.4 0.0 0.14 11.8 0.0 1.8 1 0 0 1 1 1 0 Ribonuclease B OB domain PIN_12 PF16289.5 EDO17852.1 - 0.06 13.8 4.8 1.4 9.4 1.9 3.5 2 1 0 2 2 2 0 PIN domain ABC_tran PF00005.27 EDO17853.1 - 3.4e-47 160.4 1.6 2.8e-22 79.7 0.0 3.4 3 0 0 3 3 2 2 ABC transporter ABC_tran_Xtn PF12848.7 EDO17853.1 - 2e-19 69.4 10.7 2e-19 69.4 10.7 3.0 3 0 0 3 3 1 1 ABC transporter AAA_21 PF13304.6 EDO17853.1 - 4.2e-15 56.3 13.2 0.00027 20.8 0.0 5.5 3 1 2 5 5 5 3 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EDO17853.1 - 2.5e-10 40.2 0.2 0.0035 16.8 0.2 3.7 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 EDO17853.1 - 7e-07 29.8 0.2 0.064 13.6 0.0 2.7 2 0 0 2 2 2 2 AAA ATPase domain AAA_28 PF13521.6 EDO17853.1 - 2.1e-06 28.1 2.3 0.078 13.2 0.0 3.3 3 1 0 3 3 2 2 AAA domain AAA_23 PF13476.6 EDO17853.1 - 2.2e-06 28.3 28.2 0.16 12.4 0.0 5.2 5 0 0 5 5 5 2 AAA domain RsgA_GTPase PF03193.16 EDO17853.1 - 2.6e-06 27.4 0.0 0.074 13.0 0.0 2.8 2 0 0 2 2 2 2 RsgA GTPase AAA_22 PF13401.6 EDO17853.1 - 5.7e-06 26.6 1.2 0.2 11.9 0.1 3.5 3 1 0 3 3 3 2 AAA domain NACHT PF05729.12 EDO17853.1 - 6.9e-06 26.1 0.0 0.045 13.7 0.0 2.6 2 0 0 2 2 2 2 NACHT domain AAA PF00004.29 EDO17853.1 - 7.6e-06 26.4 0.1 0.07 13.6 0.0 3.5 3 1 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 EDO17853.1 - 1.5e-05 25.0 0.1 0.44 10.6 0.0 3.6 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.6 EDO17853.1 - 1.8e-05 25.3 1.7 0.14 12.7 0.1 3.4 3 0 0 3 3 2 2 AAA domain AAA_29 PF13555.6 EDO17853.1 - 1.9e-05 24.3 3.1 0.12 12.1 0.0 3.0 3 0 0 3 3 2 2 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 EDO17853.1 - 4.1e-05 23.6 0.7 0.12 12.4 0.1 3.2 2 1 0 2 2 2 2 50S ribosome-binding GTPase ATP-synt_ab PF00006.25 EDO17853.1 - 0.00025 20.8 0.0 0.078 12.6 0.0 2.3 2 0 0 2 2 2 1 ATP synthase alpha/beta family, nucleotide-binding domain AAA_33 PF13671.6 EDO17853.1 - 0.00026 21.2 1.3 0.23 11.6 0.0 3.1 3 1 0 3 3 2 1 AAA domain PduV-EutP PF10662.9 EDO17853.1 - 0.00028 20.6 2.4 0.32 10.7 0.1 3.7 4 0 0 4 4 4 1 Ethanolamine utilisation - propanediol utilisation AAA_24 PF13479.6 EDO17853.1 - 0.0004 20.2 0.0 0.93 9.2 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_30 PF13604.6 EDO17853.1 - 0.00056 19.7 0.0 0.19 11.4 0.0 3.3 4 0 0 4 4 3 1 AAA domain RNA_helicase PF00910.22 EDO17853.1 - 0.00057 20.2 2.3 1 9.8 0.0 3.8 4 0 0 4 4 3 1 RNA helicase NB-ARC PF00931.22 EDO17853.1 - 0.00059 19.1 0.0 0.56 9.3 0.0 2.8 2 1 0 2 2 2 1 NB-ARC domain Roc PF08477.13 EDO17853.1 - 0.0011 19.2 0.0 1.8 8.8 0.0 2.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase AAA_5 PF07728.14 EDO17853.1 - 0.0015 18.5 0.2 2.3 8.2 0.0 2.9 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_15 PF13175.6 EDO17853.1 - 0.0017 18.1 28.8 0.065 12.9 0.0 4.8 3 1 1 4 4 4 1 AAA ATPase domain ATPase_2 PF01637.18 EDO17853.1 - 0.002 18.1 5.1 0.17 11.8 0.0 3.1 3 0 0 3 3 2 1 ATPase domain predominantly from Archaea Dynamin_N PF00350.23 EDO17853.1 - 0.0025 17.9 2.8 0.11 12.5 0.0 3.6 4 0 0 4 4 3 1 Dynamin family AAA_7 PF12775.7 EDO17853.1 - 0.0026 17.3 0.0 0.56 9.7 0.0 2.4 2 0 0 2 2 2 1 P-loop containing dynein motor region TsaE PF02367.17 EDO17853.1 - 0.0043 17.0 0.0 0.62 10.1 0.0 2.7 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE Zeta_toxin PF06414.12 EDO17853.1 - 0.0054 16.0 0.0 1.7 7.9 0.0 2.8 2 0 0 2 2 2 1 Zeta toxin Septin PF00735.18 EDO17853.1 - 0.0079 15.5 0.1 2.2 7.5 0.0 2.6 2 0 0 2 2 2 1 Septin MeaB PF03308.16 EDO17853.1 - 0.0091 15.0 0.5 1.9 7.4 0.0 3.1 2 1 1 3 3 3 1 Methylmalonyl Co-A mutase-associated GTPase MeaB SbcCD_C PF13558.6 EDO17853.1 - 0.0097 16.1 0.3 7.7 6.8 0.0 3.4 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit DUF815 PF05673.13 EDO17853.1 - 0.0099 15.1 0.4 5.5 6.1 0.0 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF815) MobB PF03205.14 EDO17853.1 - 0.014 15.3 0.0 0.33 10.9 0.0 2.5 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B NTPase_1 PF03266.15 EDO17853.1 - 0.015 15.2 0.0 1.7 8.5 0.0 2.6 2 0 0 2 2 2 0 NTPase Pox_A32 PF04665.12 EDO17853.1 - 0.015 14.8 1.3 0.73 9.2 0.0 3.1 3 0 0 3 3 3 0 Poxvirus A32 protein G-alpha PF00503.20 EDO17853.1 - 0.015 14.4 4.6 0.89 8.6 0.0 3.0 3 0 0 3 3 3 0 G-protein alpha subunit AAA_25 PF13481.6 EDO17853.1 - 0.017 14.7 0.0 1.5 8.4 0.0 2.5 2 0 0 2 2 2 0 AAA domain FeoB_N PF02421.18 EDO17853.1 - 0.021 14.3 0.0 6.7 6.2 0.0 2.6 2 0 0 2 2 2 0 Ferrous iron transport protein B SRP54 PF00448.22 EDO17853.1 - 0.033 13.8 0.0 2.1 7.9 0.0 2.7 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain cobW PF02492.19 EDO17853.1 - 0.033 13.8 0.1 4.3 6.9 0.1 2.6 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain TrwB_AAD_bind PF10412.9 EDO17853.1 - 0.049 12.5 0.1 0.21 10.4 0.0 1.9 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain TraF_2 PF13729.6 EDO17853.1 - 0.072 12.5 1.2 0.26 10.6 0.0 2.1 2 0 0 2 2 2 0 F plasmid transfer operon, TraF, protein Ras PF00071.22 EDO17853.1 - 0.11 12.0 1.7 9.1 5.9 0.0 3.3 4 0 0 4 4 4 0 Ras family AAA_19 PF13245.6 EDO17853.1 - 0.16 12.3 0.3 1.1 9.6 0.0 2.6 3 0 0 3 3 1 0 AAA domain DUF2813 PF11398.8 EDO17853.1 - 0.17 11.1 7.5 0.4 9.9 0.0 3.9 3 1 1 4 4 4 0 Protein of unknown function (DUF2813) CENP-O PF09496.10 EDO17853.1 - 0.47 10.4 7.9 0.4 10.6 2.3 2.8 3 0 0 3 3 3 0 Cenp-O kinetochore centromere component AAA_17 PF13207.6 EDO17853.1 - 0.78 10.2 6.0 17 5.8 0.1 3.6 3 1 0 3 3 3 0 AAA domain DUF87 PF01935.17 EDO17853.1 - 1.3 9.0 0.0 1.3 9.0 0.0 5.0 5 1 1 6 6 5 0 Helicase HerA, central domain MCU PF04678.13 EDO17853.1 - 6.3 6.9 8.8 2.1 8.4 0.1 3.2 3 0 0 3 3 3 0 Mitochondrial calcium uniporter PRELI PF04707.14 EDO17854.1 - 2.8e-57 192.9 0.2 4.6e-57 192.2 0.2 1.3 1 0 0 1 1 1 1 PRELI-like family CBM49 PF09478.10 EDO17854.1 - 0.0022 18.3 0.4 0.0074 16.6 0.2 2.0 2 0 0 2 2 2 1 Carbohydrate binding domain CBM49 Bunya_RdRp PF04196.12 EDO17854.1 - 0.0039 15.7 0.2 0.0041 15.5 0.2 1.1 1 0 0 1 1 1 1 Bunyavirus RNA dependent RNA polymerase Cortex-I_coil PF09304.10 EDO17854.1 - 0.016 15.4 0.2 0.028 14.6 0.2 1.4 1 0 0 1 1 1 0 Cortexillin I, coiled coil DHHC PF01529.20 EDO17855.1 - 0.047 13.8 0.2 0.081 13.0 0.2 1.4 1 0 0 1 1 1 0 DHHC palmitoyltransferase Catalase PF00199.19 EDO17855.1 - 0.054 12.6 0.5 0.66 9.0 0.1 2.0 2 0 0 2 2 2 0 Catalase Peptidase_M24 PF00557.24 EDO17857.1 - 5.6e-53 179.7 0.1 7.5e-53 179.3 0.1 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 zf-C6H2 PF15801.5 EDO17857.1 - 2.7e-16 59.6 6.7 2.7e-16 59.6 6.7 1.9 2 0 0 2 2 2 1 zf-MYND-like zinc finger, mRNA-binding ATP-cone PF03477.16 EDO17857.1 - 0.037 14.6 0.1 12 6.5 0.0 2.4 2 0 0 2 2 2 0 ATP cone domain zf-MYND PF01753.18 EDO17857.1 - 2.3 8.4 12.9 0.12 12.5 4.7 2.8 3 0 0 3 3 3 0 MYND finger Cpn60_TCP1 PF00118.24 EDO17858.1 - 5.6e-157 523.3 2.6 6.3e-157 523.1 2.6 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family zf-CCCH PF00642.24 EDO17859.1 - 9e-08 31.8 2.2 2e-07 30.7 2.2 1.7 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 EDO17859.1 - 4.8e-07 29.6 9.9 1.1e-06 28.5 9.9 1.7 1 0 0 1 1 1 1 Zinc finger domain zf-CCCH_4 PF18044.1 EDO17859.1 - 7.9e-06 25.6 4.2 1.6e-05 24.6 4.2 1.6 1 0 0 1 1 1 1 CCCH-type zinc finger Torus PF16131.5 EDO17859.1 - 0.00034 21.3 0.7 0.00074 20.2 0.7 1.5 1 0 0 1 1 1 1 Torus domain zf-CCCH_2 PF14608.6 EDO17859.1 - 0.21 12.1 7.4 0.51 10.9 7.4 1.7 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger Arv1 PF04161.13 EDO17860.1 - 6.2e-63 212.7 7.2 8.9e-63 212.2 7.2 1.2 1 0 0 1 1 1 1 Arv1-like family PI3Ka PF00613.20 EDO17861.1 - 1.9e-70 236.0 3.6 3.3e-70 235.3 3.6 1.3 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3_PI4_kinase PF00454.27 EDO17861.1 - 2e-53 181.8 0.7 2.6e-50 171.6 0.1 3.0 2 1 0 2 2 2 1 Phosphatidylinositol 3- and 4-kinase PI3K_C2 PF00792.24 EDO17861.1 - 1.6e-23 83.2 0.3 3.8e-23 82.0 0.3 1.7 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 AMMECR1 PF01871.17 EDO17862.1 - 4.1e-38 130.6 0.0 5.1e-38 130.3 0.0 1.1 1 0 0 1 1 1 1 AMMECR1 Topo_Zn_Ribbon PF08272.11 EDO17862.1 - 0.033 13.8 0.1 0.091 12.4 0.1 1.7 1 0 0 1 1 1 0 Topoisomerase I zinc-ribbon-like DUF971 PF06155.12 EDO17862.1 - 0.14 12.8 0.1 0.33 11.6 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF971) adh_short PF00106.25 EDO17863.1 - 2.1e-51 174.2 0.0 2.7e-51 173.8 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EDO17863.1 - 1.7e-33 116.2 0.0 2.1e-33 115.9 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EDO17863.1 - 1.9e-12 47.4 0.0 2.6e-12 47.0 0.0 1.1 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 EDO17863.1 - 0.0015 17.9 0.0 0.0022 17.4 0.0 1.2 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) Polysacc_synt_2 PF02719.15 EDO17863.1 - 0.0049 16.1 0.1 0.0071 15.5 0.1 1.3 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein Epimerase PF01370.21 EDO17863.1 - 0.0065 16.0 0.1 0.031 13.7 0.0 2.2 2 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family Sacchrp_dh_NADP PF03435.18 EDO17863.1 - 0.014 15.7 0.0 0.025 14.8 0.0 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Eno-Rase_NADH_b PF12242.8 EDO17863.1 - 0.096 12.5 0.1 0.24 11.2 0.1 1.6 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Ribosomal_S19 PF00203.21 EDO17863.1 - 0.14 12.0 0.1 0.39 10.6 0.1 1.8 1 1 1 2 2 2 0 Ribosomal protein S19 SNF2_N PF00176.23 EDO17864.1 - 2.6e-71 240.2 0.4 5.9e-71 239.0 0.4 1.6 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EDO17864.1 - 1.5e-19 70.4 0.3 2.6e-18 66.4 0.0 2.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Bromodomain PF00439.25 EDO17864.1 - 5.7e-13 48.8 1.1 1.9e-12 47.1 1.1 1.9 1 0 0 1 1 1 1 Bromodomain SnAC PF14619.6 EDO17864.1 - 8.2e-11 42.4 0.8 8.2e-11 42.4 0.8 4.3 3 1 1 4 4 4 1 Snf2-ATP coupling, chromatin remodelling complex ResIII PF04851.15 EDO17864.1 - 6e-07 29.6 0.0 6e-07 29.6 0.0 3.7 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit QLQ PF08880.11 EDO17864.1 - 2.2e-05 24.1 0.2 8.6e-05 22.2 0.2 2.1 1 0 0 1 1 1 1 QLQ HSA PF07529.13 EDO17864.1 - 0.00018 21.7 5.4 0.00018 21.7 5.4 4.2 3 1 1 4 4 4 2 HSA TAFII55_N PF04658.13 EDO17865.1 - 4.3e-51 172.8 0.1 4.3e-51 172.8 0.1 3.5 3 1 0 3 3 3 1 TAFII55 protein conserved region RrnaAD PF00398.20 EDO17866.1 - 4.3e-55 186.6 0.1 5e-55 186.4 0.1 1.0 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Sigma_reg_N PF13800.6 EDO17867.1 - 8 6.8 12.2 0.72 10.2 6.5 2.3 2 0 0 2 2 2 0 Sigma factor regulator N-terminal Phage_Gp23 PF10669.9 EDO17867.1 - 8.6 6.7 9.1 25 5.2 2.5 2.7 2 0 0 2 2 2 0 Protein gp23 (Bacteriophage A118) S1 PF00575.23 EDO17868.1 - 3.1e-52 174.8 25.8 1.8e-09 37.8 0.0 12.1 11 1 0 12 12 12 8 S1 RNA binding domain TPR_19 PF14559.6 EDO17868.1 - 2.5e-07 31.1 0.0 0.34 11.5 0.0 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat Suf PF05843.14 EDO17868.1 - 3.9e-07 30.4 3.9 1.9e-06 28.1 2.2 4.3 3 1 2 5 5 5 3 Suppressor of forked protein (Suf) TPR_14 PF13428.6 EDO17868.1 - 2.8e-05 24.6 0.1 1.8 9.6 0.0 4.5 4 1 1 5 5 5 1 Tetratricopeptide repeat Mad3_BUB1_I PF08311.12 EDO17868.1 - 0.00047 20.1 3.4 0.11 12.5 0.6 2.7 2 0 0 2 2 2 2 Mad3/BUB1 homology region 1 TPR_16 PF13432.6 EDO17868.1 - 0.00089 19.9 0.0 4.7 8.0 0.0 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat OapA PF04225.12 EDO17868.1 - 0.002 18.2 1.2 0.26 11.4 0.0 3.9 2 1 1 3 3 3 1 Opacity-associated protein A LysM-like domain RNase_II_C_S1 PF18614.1 EDO17868.1 - 0.077 13.0 0.1 5 7.1 0.0 2.8 2 0 0 2 2 2 0 RNase II-type exonuclease C-terminal S1 domain RNA_pol_Rbc25 PF08292.12 EDO17868.1 - 2 8.7 14.1 4.1 7.6 0.0 6.6 7 0 0 7 7 7 0 RNA polymerase III subunit Rpc25 Zip PF02535.22 EDO17869.1 - 4.4e-41 141.2 12.1 1.6e-26 93.3 3.8 2.7 1 1 0 2 2 2 2 ZIP Zinc transporter TPR_2 PF07719.17 EDO17870.1 - 7.5e-11 41.3 1.1 0.00068 19.6 0.1 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 EDO17870.1 - 3.9e-10 39.1 2.7 0.00033 20.4 0.1 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 EDO17870.1 - 8.4e-07 28.7 4.3 0.0025 17.9 0.2 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 EDO17870.1 - 1.6e-06 28.3 0.0 0.12 12.7 0.0 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 EDO17870.1 - 9.8e-06 25.3 0.5 1.2 9.3 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat F-box-like PF12937.7 EDO17870.1 - 9.7e-05 22.2 0.0 0.00019 21.3 0.0 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EDO17870.1 - 0.00048 19.9 1.0 0.002 18.0 0.1 2.5 2 0 0 2 2 2 1 F-box domain TPR_11 PF13414.6 EDO17870.1 - 0.0034 17.0 0.5 0.46 10.2 0.0 2.7 2 1 0 2 2 2 1 TPR repeat TPR_10 PF13374.6 EDO17870.1 - 0.022 14.6 0.0 3.4 7.7 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat MIT PF04212.18 EDO17870.1 - 0.026 14.6 0.2 1.4 9.0 0.0 2.7 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain TPR_14 PF13428.6 EDO17870.1 - 0.06 14.2 0.0 20 6.4 0.0 3.0 2 1 1 3 3 3 0 Tetratricopeptide repeat PPR PF01535.20 EDO17870.1 - 0.15 12.4 0.2 0.78 10.1 0.0 2.4 2 0 0 2 2 2 0 PPR repeat Flavoprotein PF02441.19 EDO17870.1 - 0.15 11.8 0.0 0.33 10.7 0.0 1.6 1 0 0 1 1 1 0 Flavoprotein TPR_6 PF13174.6 EDO17870.1 - 0.32 11.7 1.1 5.2 7.9 0.0 2.9 3 0 0 3 3 2 0 Tetratricopeptide repeat ENTH PF01417.20 EDO17870.1 - 0.41 10.7 3.7 0.22 11.6 0.2 2.4 3 0 0 3 3 3 0 ENTH domain DUF3336 PF11815.8 EDO17871.1 - 6.1e-36 123.2 6.2 6.1e-36 123.2 6.2 2.4 3 0 0 3 3 3 1 Domain of unknown function (DUF3336) Patatin PF01734.22 EDO17871.1 - 9.8e-27 94.5 0.0 1.8e-26 93.6 0.0 1.4 1 0 0 1 1 1 1 Patatin-like phospholipase LIM PF00412.22 EDO17872.1 - 4.2e-15 55.7 21.8 6.9e-10 39.0 8.9 2.4 2 0 0 2 2 2 2 LIM domain Whi5 PF08528.11 EDO17873.1 - 5.1e-11 41.9 0.3 1.4e-10 40.6 0.3 1.8 1 0 0 1 1 1 1 Whi5 like Abhydrolase_6 PF12697.7 EDO17874.1 - 1.2e-17 65.3 0.0 1.5e-17 65.0 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Esterase PF00756.20 EDO17874.1 - 2.1e-05 24.3 0.0 0.0018 17.9 0.0 2.2 2 0 0 2 2 2 2 Putative esterase Hydrolase_4 PF12146.8 EDO17874.1 - 6e-05 22.4 0.0 0.00021 20.6 0.0 1.9 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EDO17874.1 - 6.4e-05 22.7 0.1 0.00027 20.7 0.1 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold PGAP1 PF07819.13 EDO17874.1 - 0.042 13.6 0.1 0.11 12.2 0.1 1.9 1 1 0 1 1 1 0 PGAP1-like protein Kinesin_assoc PF16183.5 EDO17874.1 - 0.068 13.3 0.0 3 8.0 0.0 2.2 2 0 0 2 2 2 0 Kinesin-associated ERCC3_RAD25_C PF16203.5 EDO17875.1 - 1.5e-123 410.8 0.5 1.5e-123 410.8 0.5 2.0 2 0 0 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase Helicase_C_3 PF13625.6 EDO17875.1 - 3.8e-36 124.0 0.0 9e-36 122.8 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDO17875.1 - 1.3e-16 61.1 0.1 5e-16 59.2 0.0 2.1 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EDO17875.1 - 8.8e-12 45.4 0.1 8.8e-12 45.4 0.1 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain SNF2_N PF00176.23 EDO17875.1 - 1.7e-09 36.9 0.1 2.5e-09 36.3 0.1 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain DEAD PF00270.29 EDO17875.1 - 3.9e-05 23.5 0.0 9.4e-05 22.2 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase SBP_bac_6 PF13343.6 EDO17875.1 - 0.035 13.5 0.0 0.09 12.2 0.0 1.6 1 0 0 1 1 1 0 Bacterial extracellular solute-binding protein Nbs1_C PF08599.10 EDO17875.1 - 0.28 11.3 0.0 0.28 11.3 0.0 2.5 3 0 0 3 3 3 0 DNA damage repair protein Nbs1 Med3 PF11593.8 EDO17875.1 - 0.35 10.0 11.6 0.013 14.7 5.5 1.6 2 0 0 2 2 2 0 Mediator complex subunit 3 fungal PGA2 PF07543.12 EDO17875.1 - 0.63 10.0 5.4 0.89 9.5 3.7 2.1 2 0 0 2 2 2 0 Protein trafficking PGA2 Pantoate_ligase PF02569.15 EDO17876.1 - 5.5e-94 314.3 0.0 6.2e-94 314.1 0.0 1.0 1 0 0 1 1 1 1 Pantoate-beta-alanine ligase FAD_syn PF06574.12 EDO17876.1 - 0.025 14.5 0.0 0.054 13.4 0.0 1.5 1 0 0 1 1 1 0 FAD synthetase HATPase_c PF02518.26 EDO17877.1 - 1.4e-28 99.6 0.5 2.6e-21 76.2 0.0 2.6 1 1 1 2 2 2 2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 EDO17877.1 - 1.4e-25 89.7 0.4 3.5e-25 88.3 0.4 1.8 1 0 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.25 EDO17877.1 - 4.5e-13 49.0 0.4 1.6e-12 47.2 0.2 2.1 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain FAM76 PF16046.5 EDO17877.1 - 1.6 8.0 4.6 3.9 6.8 4.6 1.6 1 0 0 1 1 1 0 FAM76 protein ubiquitin PF00240.23 EDO17878.1 - 3.7e-34 116.3 0.6 4.9e-34 115.9 0.6 1.2 1 0 0 1 1 1 1 Ubiquitin family Ribosomal_L40e PF01020.17 EDO17878.1 - 9.2e-31 105.5 11.4 1.4e-30 104.9 11.4 1.3 1 0 0 1 1 1 1 Ribosomal L40e family Rad60-SLD PF11976.8 EDO17878.1 - 3e-16 59.0 0.7 3e-16 59.0 0.7 1.5 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EDO17878.1 - 2e-05 24.9 0.1 7.4e-05 23.1 0.1 1.8 1 1 0 1 1 1 1 Ubiquitin-like domain Ubiquitin_5 PF18037.1 EDO17878.1 - 0.0037 17.6 0.0 0.0055 17.0 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-like domain TBK1_ULD PF18396.1 EDO17878.1 - 0.0039 17.1 0.0 0.0051 16.7 0.0 1.3 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain Rad60-SLD_2 PF13881.6 EDO17878.1 - 0.0057 16.7 0.0 0.012 15.7 0.0 1.6 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_4 PF18036.1 EDO17878.1 - 0.014 15.4 1.0 4.2 7.5 0.2 2.2 2 0 0 2 2 2 0 Ubiquitin-like domain DUF2407 PF10302.9 EDO17878.1 - 0.026 15.1 0.1 0.032 14.8 0.1 1.3 1 1 0 1 1 1 0 DUF2407 ubiquitin-like domain Sde2_N_Ubi PF13019.6 EDO17878.1 - 0.08 12.8 0.0 0.11 12.3 0.0 1.2 1 0 0 1 1 1 0 Silencing defective 2 N-terminal ubiquitin domain ADIP PF11559.8 EDO17879.1 - 0.0013 18.8 14.4 0.0013 18.8 14.4 13.4 3 3 11 15 15 15 3 Afadin- and alpha -actinin-Binding Golgin_A5 PF09787.9 EDO17879.1 - 0.0041 16.6 15.9 0.0041 16.6 15.9 8.8 2 2 4 8 8 8 1 Golgin subfamily A member 5 Rootletin PF15035.6 EDO17879.1 - 0.0061 16.6 7.4 0.0061 16.6 7.4 11.0 1 1 7 8 8 8 1 Ciliary rootlet component, centrosome cohesion zf-primase PF09329.11 EDO17880.1 - 4e-14 52.1 0.2 7.4e-14 51.3 0.2 1.5 1 0 0 1 1 1 1 Primase zinc finger DUF5088 PF17008.5 EDO17880.1 - 0.012 15.4 0.2 0.034 13.9 0.2 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF5088) tRNA_anti-codon PF01336.25 EDO17880.1 - 0.034 14.1 0.1 0.073 13.1 0.1 1.5 1 0 0 1 1 1 0 OB-fold nucleic acid binding domain Nsp1_C PF05064.13 EDO17880.1 - 0.33 10.8 5.2 0.093 12.5 1.3 2.1 2 0 0 2 2 2 0 Nsp1-like C-terminal region Pcc1 PF09341.10 EDO17881.1 - 2.4e-21 75.6 0.0 2.7e-21 75.5 0.0 1.0 1 0 0 1 1 1 1 Transcription factor Pcc1 PIN_4 PF13638.6 EDO17882.1 - 6.9e-13 49.0 0.3 6.9e-13 49.0 0.3 2.1 2 0 0 2 2 2 1 PIN domain Acetyltransf_11 PF13720.6 EDO17882.1 - 0.13 12.8 0.0 0.55 10.7 0.0 2.1 1 0 0 1 1 1 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 PEPCK_ATP PF01293.20 EDO17884.1 - 2.3e-216 718.9 0.0 2.7e-216 718.7 0.0 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase AAA_33 PF13671.6 EDO17884.1 - 0.054 13.6 0.0 0.084 13.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EDO17884.1 - 0.23 11.8 0.0 0.36 11.2 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain DNA_pol_phi PF04931.13 EDO17885.1 - 0.058 11.5 21.5 0.08 11.0 21.5 1.1 1 0 0 1 1 1 0 DNA polymerase phi Pox_Ag35 PF03286.14 EDO17885.1 - 0.12 12.1 10.7 0.26 11.1 10.7 1.5 1 0 0 1 1 1 0 Pox virus Ag35 surface protein RNA_pol_3_Rpc31 PF11705.8 EDO17885.1 - 0.14 12.4 17.9 0.24 11.6 17.9 1.4 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 Nop14 PF04147.12 EDO17885.1 - 0.19 9.9 16.5 0.23 9.7 16.5 1.1 1 0 0 1 1 1 0 Nop14-like family Vfa1 PF08432.10 EDO17885.1 - 0.22 11.9 5.0 0.37 11.1 5.0 1.5 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 DUF2722 PF10846.8 EDO17885.1 - 0.37 9.7 10.8 0.63 8.9 10.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) FAM176 PF14851.6 EDO17885.1 - 0.53 9.9 10.5 1.2 8.8 10.5 1.6 1 0 0 1 1 1 0 FAM176 family FYDLN_acid PF09538.10 EDO17885.1 - 0.73 10.5 14.9 1.6 9.4 14.9 1.6 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) Usp PF00582.26 EDO17885.1 - 0.74 10.3 3.2 11 6.5 0.0 2.3 2 0 0 2 2 2 0 Universal stress protein family RPN2_C PF18004.1 EDO17885.1 - 1.4 8.8 7.9 2.4 8.0 7.9 1.3 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain PPP4R2 PF09184.11 EDO17885.1 - 1.8 8.1 17.0 3.3 7.2 17.0 1.4 1 0 0 1 1 1 0 PPP4R2 NOA36 PF06524.12 EDO17885.1 - 2.7 7.2 17.5 4.5 6.5 17.5 1.3 1 0 0 1 1 1 0 NOA36 protein PBP_sp32 PF07222.12 EDO17885.1 - 3 7.2 7.5 5.3 6.4 7.5 1.3 1 0 0 1 1 1 0 Proacrosin binding protein sp32 RRN3 PF05327.11 EDO17885.1 - 4.1 5.8 11.5 6.4 5.2 11.5 1.3 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 DAO PF01266.24 EDO17886.1 - 4e-52 178.0 0.0 4.8e-51 174.4 0.0 2.0 1 1 0 1 1 1 1 FAD dependent oxidoreductase DAO_C PF16901.5 EDO17886.1 - 6.7e-42 142.3 0.1 1.4e-41 141.3 0.1 1.6 1 0 0 1 1 1 1 C-terminal domain of alpha-glycerophosphate oxidase FAD_binding_2 PF00890.24 EDO17886.1 - 1.5e-14 54.0 0.6 4.8e-14 52.3 0.6 1.7 1 1 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.7 EDO17886.1 - 4.5e-11 42.8 0.7 7e-07 28.9 0.2 2.4 2 0 0 2 2 2 2 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 EDO17886.1 - 7e-06 25.5 0.1 0.034 13.4 0.1 2.2 2 0 0 2 2 2 2 FAD binding domain Pyr_redox_2 PF07992.14 EDO17886.1 - 1e-05 24.9 5.0 0.00021 20.6 4.3 2.5 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EDO17886.1 - 2.4e-05 23.6 2.3 0.0013 17.9 0.3 2.2 2 0 0 2 2 2 2 Glucose inhibited division protein A HI0933_like PF03486.14 EDO17886.1 - 3e-05 22.9 0.2 5.5e-05 22.0 0.2 1.4 1 0 0 1 1 1 1 HI0933-like protein NAD_binding_8 PF13450.6 EDO17886.1 - 0.00023 21.3 2.0 0.00031 20.9 0.6 2.1 2 0 0 2 2 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 EDO17886.1 - 0.00046 19.5 0.3 0.029 13.6 0.1 2.3 2 0 0 2 2 2 1 Thi4 family Pyr_redox_3 PF13738.6 EDO17886.1 - 0.0017 17.7 1.4 0.0076 15.5 0.2 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 EDO17886.1 - 0.015 14.6 0.0 0.049 12.9 0.0 1.8 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox PF00070.27 EDO17886.1 - 0.016 15.8 0.9 0.13 12.9 0.2 2.4 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.18 EDO17886.1 - 0.62 9.9 6.6 0.13 12.2 1.3 2.6 3 1 0 3 3 3 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DUF1748 PF08520.10 EDO17887.1 - 1.3e-27 95.5 0.0 1.4e-27 95.4 0.0 1.0 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1748) Coa1 PF08695.10 EDO17888.1 - 5.5e-41 139.0 0.0 1e-40 138.1 0.0 1.4 2 0 0 2 2 2 1 Cytochrome oxidase complex assembly protein 1 DUF1827 PF08860.10 EDO17889.1 - 0.051 13.8 0.8 0.16 12.2 0.8 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF1827) CENP-B_dimeris PF09026.10 EDO17889.1 - 0.85 10.0 11.6 1.7 9.1 2.0 2.5 2 0 0 2 2 2 0 Centromere protein B dimerisation domain DUF3835 PF12927.7 EDO17889.1 - 2.8 8.8 7.0 0.76 10.7 1.6 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3835) Ribosomal_L18A PF01775.17 EDO17891.1 - 7.8e-44 148.6 3.3 1.1e-43 148.2 3.3 1.2 1 0 0 1 1 1 1 Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A Nop PF01798.18 EDO17893.1 - 1.6e-82 276.4 0.2 1.6e-82 276.4 0.2 2.1 2 0 0 2 2 2 1 snoRNA binding domain, fibrillarin NOP5NT PF08156.13 EDO17893.1 - 2.7e-19 69.3 2.1 2.7e-19 69.3 2.1 2.5 2 1 0 2 2 2 1 NOP5NT (NUC127) domain Aldolase PF01081.19 EDO17893.1 - 0.12 11.7 0.0 0.31 10.4 0.0 1.7 1 1 0 1 1 1 0 KDPG and KHG aldolase DUF4604 PF15377.6 EDO17893.1 - 0.25 11.7 48.1 0.016 15.7 42.9 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4604) RR_TM4-6 PF06459.12 EDO17893.1 - 2.1 8.1 30.4 1.7 8.4 28.6 1.9 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 DUF382 PF04037.13 EDO17894.1 - 1e-51 174.4 0.5 2.6e-51 173.1 0.0 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF382) PSP PF04046.16 EDO17894.1 - 8.7e-23 79.9 0.8 1.6e-22 79.1 0.8 1.4 1 0 0 1 1 1 1 PSP MS_channel PF00924.18 EDO17894.1 - 0.28 10.7 0.7 0.56 9.7 0.7 1.4 1 0 0 1 1 1 0 Mechanosensitive ion channel SOAR PF16533.5 EDO17894.1 - 0.52 10.3 0.1 0.52 10.3 0.1 3.0 3 1 1 4 4 4 0 STIM1 Orai1-activating region SLIDE PF09111.10 EDO17895.1 - 3.4e-37 127.0 11.2 2.4e-36 124.2 4.0 2.6 2 0 0 2 2 2 2 SLIDE HAND PF09110.11 EDO17895.1 - 1.3e-34 119.3 11.8 1.3e-34 119.3 11.8 2.7 2 1 1 3 3 3 1 HAND Di19_C PF14571.6 EDO17895.1 - 1.8 9.2 5.4 0.98 10.0 2.1 2.3 2 0 0 2 2 2 0 Stress-induced protein Di19, C-terminal Occludin_ELL PF07303.13 EDO17895.1 - 6.2 7.6 15.9 2.7 8.8 2.1 3.1 2 1 1 3 3 3 0 Occludin homology domain DUF1690 PF07956.11 EDO17895.1 - 7.2 7.0 12.0 0.45 10.9 4.4 2.5 3 0 0 3 3 3 0 Protein of Unknown function (DUF1690) SNF2_N PF00176.23 EDO17896.1 - 8e-76 255.0 0.6 1.5e-75 254.1 0.6 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EDO17896.1 - 5.5e-22 78.2 0.1 9e-20 71.1 0.0 3.2 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDO17896.1 - 5.1e-14 52.6 4.5 8.7e-14 51.9 0.0 3.1 3 1 0 3 3 3 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EDO17896.1 - 1.6e-06 28.0 0.1 6.7e-06 26.0 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase HDA2-3 PF11496.8 EDO17896.1 - 1.3e-05 24.5 0.2 8.4e-05 21.9 0.1 2.4 1 1 1 2 2 2 1 Class II histone deacetylase complex subunits 2 and 3 ERCC3_RAD25_C PF16203.5 EDO17896.1 - 0.011 14.9 0.2 0.011 14.9 0.2 1.9 2 0 0 2 2 2 0 ERCC3/RAD25/XPB C-terminal helicase AAA_14 PF13173.6 EDO17896.1 - 0.017 15.2 0.1 0.094 12.8 0.1 2.3 1 0 0 1 1 1 0 AAA domain Rhodanese PF00581.20 EDO17896.1 - 0.081 13.4 0.1 0.37 11.3 0.0 2.2 2 0 0 2 2 2 0 Rhodanese-like domain CPSase_sm_chain PF00988.22 EDO17897.1 - 6.8e-46 155.3 0.0 1.2e-45 154.4 0.0 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain GATase PF00117.28 EDO17897.1 - 2.8e-45 154.4 0.0 4.1e-45 153.9 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 EDO17897.1 - 1.4e-05 25.0 0.6 0.00037 20.3 0.1 2.8 2 1 0 2 2 2 1 Peptidase C26 DJ-1_PfpI PF01965.24 EDO17897.1 - 0.0054 16.5 0.0 0.0094 15.8 0.0 1.3 1 0 0 1 1 1 1 DJ-1/PfpI family RET_CLD3 PF17812.1 EDO17897.1 - 0.095 13.0 0.0 0.36 11.1 0.0 1.9 1 0 0 1 1 1 0 RET Cadherin like domain 3 DUF4473 PF14747.6 EDO17897.1 - 0.14 12.7 0.1 0.31 11.6 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4473) RGS PF00615.19 EDO17898.1 - 0.00051 20.3 0.3 0.021 15.1 0.0 2.6 2 0 0 2 2 2 2 Regulator of G protein signaling domain ChAPs PF09295.10 EDO17899.1 - 2.4e-165 550.3 2.2 3.1e-165 550.0 2.2 1.1 1 0 0 1 1 1 1 ChAPs (Chs5p-Arf1p-binding proteins) TPR_2 PF07719.17 EDO17899.1 - 0.006 16.6 0.1 0.62 10.3 0.0 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.6 EDO17899.1 - 0.025 15.2 0.0 1.1e+02 3.8 0.0 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EDO17899.1 - 0.21 11.8 1.4 27 5.1 0.0 2.9 3 0 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TFIID-31kDa PF02291.15 EDO17900.1 - 5e-48 162.2 0.0 1.2e-47 161.0 0.0 1.5 1 1 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Fip1 PF05182.13 EDO17901.1 - 3.7e-21 74.3 0.5 3.7e-21 74.3 0.5 2.0 2 0 0 2 2 2 1 Fip1 motif Serglycin PF04360.12 EDO17901.1 - 2.6 8.0 10.2 0.11 12.5 4.0 1.9 2 0 0 2 2 2 0 Serglycin PUF PF00806.19 EDO17904.1 - 4.3e-29 98.5 2.8 0.00024 20.6 0.0 6.8 6 0 0 6 6 6 5 Pumilio-family RNA binding repeat RRM_1 PF00076.22 EDO17904.1 - 6.1e-06 26.0 0.0 1.6e-05 24.6 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) F-box-like PF12937.7 EDO17905.1 - 6.6e-07 29.1 0.8 1.9e-06 27.6 0.8 1.9 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EDO17905.1 - 2.1e-05 24.2 0.3 7.9e-05 22.4 0.3 2.0 1 0 0 1 1 1 1 F-box domain G-gamma PF00631.22 EDO17906.1 - 7.3e-24 83.6 0.2 9.3e-24 83.2 0.2 1.1 1 0 0 1 1 1 1 GGL domain PCI PF01399.27 EDO17907.1 - 2e-09 37.9 0.3 2.4e-08 34.4 0.3 2.5 1 1 0 1 1 1 1 PCI domain V-ATPase_H_N PF03224.14 EDO17909.1 - 4.8e-68 229.8 10.2 4.8e-68 229.8 10.2 1.9 2 0 0 2 2 2 1 V-ATPase subunit H V-ATPase_H_C PF11698.8 EDO17909.1 - 7.7e-39 132.4 1.1 7.7e-39 132.4 1.1 2.9 3 1 0 3 3 3 1 V-ATPase subunit H Arm PF00514.23 EDO17909.1 - 0.078 13.0 0.0 6 7.1 0.0 3.3 2 0 0 2 2 2 0 Armadillo/beta-catenin-like repeat Lgl_C PF08596.10 EDO17910.1 - 2e-137 458.1 0.5 3.2e-137 457.4 0.5 1.3 1 0 0 1 1 1 1 Lethal giant larvae(Lgl) like, C-terminal ANAPC4_WD40 PF12894.7 EDO17910.1 - 1.8e-07 31.3 0.2 0.45 10.8 0.0 6.5 5 2 2 7 7 7 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EDO17910.1 - 0.00023 21.9 0.4 1 10.4 0.0 4.3 4 0 0 4 4 4 1 WD domain, G-beta repeat Proteasome PF00227.26 EDO17910.1 - 0.014 14.8 0.0 0.037 13.5 0.0 1.6 1 0 0 1 1 1 0 Proteasome subunit WD40_like PF17005.5 EDO17910.1 - 0.025 13.9 0.1 0.054 12.8 0.1 1.5 1 0 0 1 1 1 0 WD40-like domain Nucleoporin_N PF08801.11 EDO17910.1 - 0.096 11.4 2.8 5.9 5.5 0.1 2.8 3 0 0 3 3 3 0 Nup133 N terminal like HLH PF00010.26 EDO17911.1 - 3.7e-16 58.8 0.5 7.5e-16 57.8 0.5 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Got1 PF04178.12 EDO17912.1 - 1.1e-31 109.5 17.0 2e-31 108.7 17.0 1.4 1 0 0 1 1 1 1 Got1/Sft2-like family DUF2207 PF09972.9 EDO17912.1 - 0.54 9.0 6.1 2.7 6.7 5.9 1.9 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) Arrestin_C PF02752.22 EDO17913.1 - 2.7e-10 40.8 3.9 4.8e-09 36.8 1.0 3.7 2 1 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain Glyco_hydro_16 PF00722.21 EDO17915.1 - 5.8e-46 156.2 1.0 5.8e-46 156.2 1.0 1.9 2 1 0 2 2 2 1 Glycosyl hydrolases family 16 AA_permease PF00324.21 EDO17916.1 - 9e-137 456.5 36.3 1.1e-136 456.3 36.3 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EDO17916.1 - 9.7e-38 130.1 38.1 1.2e-37 129.8 38.1 1.0 1 0 0 1 1 1 1 Amino acid permease Bacteriocin_IIc PF10439.9 EDO17916.1 - 2.3 8.4 9.4 9.3 6.5 4.0 2.9 2 0 0 2 2 2 0 Bacteriocin class II with double-glycine leader peptide EIF_2_alpha PF07541.12 EDO17917.1 - 1.7e-38 131.3 0.2 3.2e-38 130.4 0.2 1.5 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 2 alpha subunit S1 PF00575.23 EDO17917.1 - 2.7e-15 56.5 1.4 6.7e-15 55.2 1.4 1.7 1 0 0 1 1 1 1 S1 RNA binding domain RcsC PF09456.10 EDO17917.1 - 0.13 12.3 0.0 0.79 9.8 0.0 2.2 2 0 0 2 2 2 0 RcsC Alpha-Beta-Loop (ABL) FGGY_N PF00370.21 EDO17918.1 - 7.7e-19 68.2 0.0 6.4e-10 39.0 0.0 2.4 2 0 0 2 2 2 2 FGGY family of carbohydrate kinases, N-terminal domain FGGY_C PF02782.16 EDO17918.1 - 2.6e-13 50.2 0.0 1e-11 45.0 0.0 2.8 2 1 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain SPC12 PF06645.13 EDO17919.1 - 2.9e-22 78.5 1.4 3.3e-22 78.3 1.4 1.0 1 0 0 1 1 1 1 Microsomal signal peptidase 12 kDa subunit (SPC12) TMEM100 PF16311.5 EDO17919.1 - 0.14 11.7 0.5 0.22 11.1 0.5 1.3 1 1 0 1 1 1 0 Transmembrane protein 100 Deltameth_res PF16020.5 EDO17919.1 - 0.3 11.0 2.3 0.3 11.0 0.6 1.8 1 1 1 2 2 2 0 Deltamethrin resistance DUF3102 PF11300.8 EDO17920.1 - 0.013 15.7 0.7 0.039 14.2 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3102) DUF5572 PF17733.1 EDO17921.1 - 8.4e-11 41.5 0.3 1.5e-10 40.8 0.3 1.4 1 0 0 1 1 1 1 Family of unknown function (DUF5572) Mannosyl_trans PF05007.13 EDO17922.1 - 2.1e-80 270.3 32.1 2.1e-80 270.3 32.1 2.4 2 2 0 3 3 3 1 Mannosyltransferase (PIG-M) PIG-U PF06728.13 EDO17922.1 - 1.9e-08 33.8 44.0 2.7e-08 33.3 44.0 1.2 1 0 0 1 1 1 1 GPI transamidase subunit PIG-U GT87 PF09594.10 EDO17922.1 - 0.00046 20.0 2.0 0.00046 20.0 2.0 2.2 1 1 1 2 2 2 1 Glycosyltransferase family 87 RNase_PH PF01138.21 EDO17923.1 - 2.5e-27 96.0 0.1 3.8e-27 95.4 0.1 1.3 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 EDO17923.1 - 7.9e-05 22.6 0.5 0.00038 20.4 0.1 2.1 2 0 0 2 2 2 1 3' exoribonuclease family, domain 2 CTP_transf_like PF01467.26 EDO17924.1 - 1.2e-33 116.4 0.0 2e-33 115.6 0.0 1.4 1 0 0 1 1 1 1 Cytidylyltransferase-like Trefoil PF00088.18 EDO17924.1 - 0.039 13.8 0.1 0.073 13.0 0.1 1.4 1 0 0 1 1 1 0 Trefoil (P-type) domain RXT2_N PF08595.11 EDO17924.1 - 5.5 7.0 16.8 0.97 9.4 8.2 2.9 3 0 0 3 3 3 0 RXT2-like, N-terminal Rotamase PF00639.21 EDO17925.1 - 8.2e-26 90.8 0.2 1.1e-25 90.5 0.2 1.1 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_3 PF13616.6 EDO17925.1 - 2.1e-19 70.2 0.0 2.7e-19 69.8 0.0 1.1 1 0 0 1 1 1 1 PPIC-type PPIASE domain WW PF00397.26 EDO17925.1 - 2.4e-09 37.1 0.8 3.7e-09 36.5 0.8 1.3 1 0 0 1 1 1 1 WW domain Rotamase_2 PF13145.6 EDO17925.1 - 2.6e-06 28.3 0.0 4.7e-06 27.4 0.0 1.5 1 1 0 1 1 1 1 PPIC-type PPIASE domain LSM PF01423.22 EDO17926.1 - 8.4e-12 44.6 0.1 1.4e-11 43.9 0.1 1.4 1 0 0 1 1 1 1 LSM domain DUF4362 PF14275.6 EDO17926.1 - 0.1 12.9 0.1 0.28 11.5 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4362) ETF PF01012.21 EDO17927.1 - 5.2e-36 124.2 0.0 6.4e-36 123.9 0.0 1.1 1 0 0 1 1 1 1 Electron transfer flavoprotein domain Thioredoxin PF00085.20 EDO17928.1 - 6.9e-16 58.1 0.0 7.6e-16 58.0 0.0 1.0 1 0 0 1 1 1 1 Thioredoxin Phosducin PF02114.16 EDO17928.1 - 0.0051 15.8 0.0 0.0057 15.6 0.0 1.0 1 0 0 1 1 1 1 Phosducin DIM1 PF02966.16 EDO17928.1 - 0.022 14.6 0.1 0.023 14.5 0.1 1.1 1 0 0 1 1 1 0 Mitosis protein DIM1 RRM_5 PF13893.6 EDO17929.1 - 0.035 13.7 0.0 0.09 12.4 0.0 1.6 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) APG6_N PF17675.1 EDO17930.1 - 0.014 16.0 12.3 0.014 16.0 12.3 2.2 2 0 0 2 2 2 0 Apg6 coiled-coil region HEAT_2 PF13646.6 EDO17930.1 - 0.071 13.5 0.0 23 5.5 0.0 3.9 3 1 1 4 4 4 0 HEAT repeats Med9 PF07544.13 EDO17930.1 - 0.19 11.9 13.2 2.1 8.5 8.9 3.8 3 0 0 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 DUF3450 PF11932.8 EDO17930.1 - 0.31 10.3 12.8 1 8.6 12.8 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) DUF1599 PF07659.11 EDO17930.1 - 1.1 9.8 3.6 44 4.6 0.0 4.0 4 0 0 4 4 4 0 Nucleotide modification associated domain 1 CENP-F_leu_zip PF10473.9 EDO17930.1 - 3.6 7.6 25.5 0.11 12.6 13.0 3.8 3 1 1 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Ipi1_N PF12333.8 EDO17930.1 - 9.6 6.9 8.0 12 6.6 0.0 4.2 4 0 0 4 4 4 0 Rix1 complex component involved in 60S ribosome maturation Thioredoxin PF00085.20 EDO17931.1 - 9.4e-31 105.9 0.3 1.1e-30 105.7 0.3 1.0 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 EDO17931.1 - 7.3e-09 36.1 0.3 3.7e-08 33.8 0.3 1.8 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 EDO17931.1 - 2.3e-06 27.8 0.1 1.9e-05 24.9 0.1 1.9 1 1 0 1 1 1 1 Thioredoxin-like Thioredoxin_9 PF14595.6 EDO17931.1 - 1.8e-05 24.5 0.0 2.1e-05 24.3 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Redoxin PF08534.10 EDO17931.1 - 6.9e-05 22.6 0.8 0.0098 15.6 0.1 2.0 1 1 1 2 2 2 2 Redoxin DIM1 PF02966.16 EDO17931.1 - 8.6e-05 22.3 0.1 0.0001 22.1 0.1 1.1 1 0 0 1 1 1 1 Mitosis protein DIM1 AhpC-TSA PF00578.21 EDO17931.1 - 0.00025 21.0 0.3 0.00053 19.9 0.3 1.6 1 1 0 1 1 1 1 AhpC/TSA family OST3_OST6 PF04756.13 EDO17931.1 - 0.00069 19.1 0.0 0.00075 18.9 0.0 1.1 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_7 PF13899.6 EDO17931.1 - 0.0043 17.2 0.2 0.0072 16.5 0.2 1.4 1 1 0 1 1 1 1 Thioredoxin-like TraF PF13728.6 EDO17931.1 - 0.0084 16.0 0.1 0.01 15.7 0.1 1.1 1 0 0 1 1 1 1 F plasmid transfer operon protein HyaE PF07449.11 EDO17931.1 - 0.041 13.8 0.0 0.067 13.2 0.0 1.3 1 0 0 1 1 1 0 Hydrogenase-1 expression protein HyaE TPP_enzyme_N PF02776.18 EDO17932.1 - 5.4e-31 107.5 0.1 8.6e-31 106.8 0.1 1.3 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.22 EDO17932.1 - 8.3e-28 96.8 0.0 3.9e-27 94.6 0.0 2.0 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.21 EDO17932.1 - 2.2e-14 53.5 0.0 3.7e-14 52.8 0.0 1.4 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain AATase PF07247.12 EDO17933.1 - 6e-57 193.3 9.7 3.3e-56 190.9 9.7 1.8 1 1 0 1 1 1 1 Alcohol acetyltransferase Ferric_reduct PF01794.19 EDO17934.1 - 5.4e-22 78.2 11.0 5.4e-22 78.2 11.0 2.4 2 0 0 2 2 2 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.12 EDO17934.1 - 0.0055 16.8 0.0 0.015 15.4 0.0 1.7 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_6 PF08030.12 EDO17934.1 - 0.014 15.5 0.0 0.093 12.9 0.0 2.3 1 1 0 1 1 1 0 Ferric reductase NAD binding domain Ribosomal_S2 PF00318.20 EDO17935.1 - 5e-23 81.5 0.1 4.6e-13 48.9 0.0 2.6 2 1 1 3 3 3 2 Ribosomal protein S2 40S_SA_C PF16122.5 EDO17935.1 - 0.004 18.5 10.1 0.0074 17.6 10.1 1.5 1 0 0 1 1 1 1 40S ribosomal protein SA C-terminus MRP-S33 PF08293.11 EDO17936.1 - 4.5e-32 110.1 0.1 7.2e-32 109.5 0.1 1.3 1 0 0 1 1 1 1 Mitochondrial ribosomal subunit S27 Ion_trans PF00520.31 EDO17937.1 - 5.7e-33 114.2 33.3 3.7e-31 108.2 17.1 3.0 2 1 0 2 2 2 2 Ion transport protein DUF957 PF06117.11 EDO17937.1 - 2.1 8.0 6.7 0.15 11.6 1.0 2.1 2 0 0 2 2 2 0 Enterobacterial protein of unknown function (DUF957) Ion_trans PF00520.31 EDO17938.1 - 7.9e-45 153.0 57.4 2.9e-28 98.8 20.1 3.2 3 0 0 3 3 3 3 Ion transport protein CRM1_C PF08767.11 EDO17939.1 - 8.3e-103 343.9 18.8 8.3e-103 343.9 18.8 3.0 3 1 1 4 4 4 1 CRM1 C terminal Xpo1 PF08389.12 EDO17939.1 - 4.8e-24 85.1 4.2 4.8e-24 85.1 4.2 3.3 2 0 0 2 2 2 1 Exportin 1-like protein CRM1_repeat_2 PF18784.1 EDO17939.1 - 6.6e-21 73.7 1.5 2.2e-20 72.1 1.5 2.0 1 0 0 1 1 1 1 CRM1 / Exportin repeat 2 CRM1_repeat_3 PF18787.1 EDO17939.1 - 2.6e-16 59.4 0.8 1.4e-15 57.1 0.1 2.8 2 0 0 2 2 2 1 CRM1 / Exportin repeat 3 IBN_N PF03810.19 EDO17939.1 - 1.5e-12 47.3 0.0 6.3e-12 45.2 0.0 2.2 1 0 0 1 1 1 1 Importin-beta N-terminal domain CRM1_repeat PF18777.1 EDO17939.1 - 1.3e-07 31.0 3.1 1.5e-07 30.8 0.2 2.7 3 0 0 3 3 3 1 Chromosome region maintenance or exportin repeat SKG6 PF08693.10 EDO17940.1 - 6.2e-15 54.3 2.4 6.2e-15 54.3 2.4 2.0 2 0 0 2 2 2 1 Transmembrane alpha-helix domain DUF4448 PF14610.6 EDO17940.1 - 0.00022 21.0 2.1 0.00082 19.2 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF4448) TMEM154 PF15102.6 EDO17940.1 - 0.00027 20.9 3.4 0.00042 20.2 0.1 2.6 2 0 0 2 2 2 1 TMEM154 protein family Mid2 PF04478.12 EDO17940.1 - 0.00039 20.3 0.2 0.0016 18.3 0.2 2.0 1 0 0 1 1 1 1 Mid2 like cell wall stress sensor Rax2 PF12768.7 EDO17940.1 - 0.0014 18.2 0.0 0.0047 16.4 0.0 1.9 1 0 0 1 1 1 1 Cortical protein marker for cell polarity Adeno_E3_CR2 PF02439.15 EDO17940.1 - 0.0032 17.2 0.2 0.0064 16.2 0.2 1.5 1 0 0 1 1 1 1 Adenovirus E3 region protein CR2 EphA2_TM PF14575.6 EDO17940.1 - 0.0059 17.5 0.0 0.13 13.2 0.0 2.7 2 0 0 2 2 2 1 Ephrin type-A receptor 2 transmembrane domain Syndecan PF01034.20 EDO17940.1 - 0.014 15.3 0.1 0.033 14.1 0.1 1.5 1 0 0 1 1 1 0 Syndecan domain Orf78 PF06024.12 EDO17940.1 - 0.017 15.4 0.0 0.076 13.3 0.0 2.2 2 0 0 2 2 1 0 Orf78 (ac78) Amnionless PF14828.6 EDO17940.1 - 0.02 13.7 0.0 0.043 12.7 0.0 1.5 1 0 0 1 1 1 0 Amnionless Herpes_gE PF02480.16 EDO17940.1 - 0.051 12.3 0.0 0.086 11.6 0.0 1.4 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E TMEM65 PF10507.9 EDO17940.1 - 0.11 12.5 0.1 4.3 7.3 0.0 2.6 2 0 0 2 2 2 0 Transmembrane protein 65 TMEM51 PF15345.6 EDO17940.1 - 0.18 11.6 4.5 0.036 13.9 0.5 2.0 2 1 0 2 2 2 0 Transmembrane protein 51 Glycophorin_A PF01102.18 EDO17940.1 - 0.2 11.9 0.1 0.2 11.9 0.1 2.3 3 0 0 3 3 3 0 Glycophorin A DUF2973 PF11189.8 EDO17940.1 - 0.46 10.6 2.1 0.94 9.6 0.0 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF2973) SMI1_KNR4 PF09346.10 EDO17941.1 - 3.2e-32 111.7 0.0 3.2e-32 111.7 0.0 3.2 3 1 1 4 4 4 1 SMI1 / KNR4 family (SUKH-1) Ank_2 PF12796.7 EDO17942.1 - 3.6e-31 107.6 0.0 8.6e-15 55.1 0.0 3.8 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EDO17942.1 - 1.9e-24 85.7 0.3 3.4e-09 37.1 0.0 5.1 1 1 5 6 6 6 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EDO17942.1 - 2.1e-21 73.7 0.2 0.041 14.4 0.0 7.2 7 0 0 7 7 7 5 Ankyrin repeat Ank_5 PF13857.6 EDO17942.1 - 1.2e-20 73.3 0.1 0.0019 18.5 0.1 5.8 2 2 2 5 5 5 5 Ankyrin repeats (many copies) Ank PF00023.30 EDO17942.1 - 5.2e-20 70.9 0.0 0.0042 17.5 0.0 6.9 6 0 0 6 6 6 6 Ankyrin repeat SPX PF03105.19 EDO17942.1 - 6.4e-20 72.4 15.1 1.5e-07 31.7 2.3 3.4 1 1 2 3 3 3 3 SPX domain ERM PF00769.19 EDO17942.1 - 8.9 6.0 11.7 0.17 11.7 3.7 2.0 3 0 0 3 3 3 0 Ezrin/radixin/moesin family HATPase_c_4 PF13749.6 EDO17943.1 - 0.041 14.0 0.0 0.1 12.7 0.0 1.6 2 0 0 2 2 2 0 Putative ATP-dependent DNA helicase recG C-terminal Kelch_3 PF13415.6 EDO17944.1 - 5.6e-31 106.2 0.1 1.8e-05 24.9 0.0 5.9 5 0 0 5 5 5 5 Galactose oxidase, central domain Kelch_4 PF13418.6 EDO17944.1 - 1.2e-27 95.7 12.2 6.8e-06 26.0 0.2 6.8 5 2 1 6 6 6 6 Galactose oxidase, central domain Kelch_5 PF13854.6 EDO17944.1 - 6.1e-26 89.9 3.2 0.00046 20.1 0.0 6.2 6 0 0 6 6 6 5 Kelch motif Kelch_6 PF13964.6 EDO17944.1 - 7.6e-22 76.8 4.6 2.2e-05 24.6 0.1 6.7 5 1 1 6 6 6 5 Kelch motif Kelch_1 PF01344.25 EDO17944.1 - 1.2e-17 63.2 0.2 0.00056 19.4 0.1 5.5 5 0 0 5 5 5 5 Kelch motif Kelch_2 PF07646.15 EDO17944.1 - 7e-12 44.8 4.4 0.54 10.3 0.1 6.1 6 1 0 6 6 6 5 Kelch motif Seadorna_VP6 PF07407.11 EDO17944.1 - 3.8 6.4 6.6 1.9 7.3 4.0 1.7 1 1 0 1 1 1 0 Seadornavirus VP6 protein MPC PF03650.13 EDO17945.1 - 1e-48 164.0 0.1 1.2e-48 163.8 0.1 1.0 1 0 0 1 1 1 1 Mitochondrial pyruvate carriers RNase_T PF00929.24 EDO17945.1 - 0.11 13.1 0.0 0.13 12.8 0.0 1.1 1 0 0 1 1 1 0 Exonuclease SDA1 PF05285.12 EDO17946.1 - 3.2e-81 273.5 47.7 5.7e-81 272.6 38.9 3.1 2 1 0 2 2 2 1 SDA1 NUC130_3NT PF08158.12 EDO17946.1 - 1.1e-21 76.9 1.5 2.4e-21 75.8 0.1 2.3 2 0 0 2 2 2 1 NUC130/3NT domain AGS_C PF18134.1 EDO17946.1 - 0.014 15.4 0.2 0.014 15.4 0.2 2.4 3 0 0 3 3 3 0 Adenylyl/Guanylyl and SMODS C-terminal sensor domain TIM21 PF08294.11 EDO17946.1 - 0.64 9.9 3.6 0.45 10.4 0.1 2.3 2 0 0 2 2 2 0 TIM21 TFIIB PF00382.19 EDO17947.1 - 5e-57 189.9 0.9 1.2e-28 98.9 0.1 2.6 2 0 0 2 2 2 2 Transcription factor TFIIB repeat BRF1 PF07741.13 EDO17947.1 - 1.9e-30 105.1 6.1 1.9e-30 105.1 6.1 2.7 2 1 0 2 2 2 1 Brf1-like TBP-binding domain TF_Zn_Ribbon PF08271.12 EDO17947.1 - 8.8e-10 37.9 3.2 1.8e-09 37.0 3.2 1.6 1 0 0 1 1 1 1 TFIIB zinc-binding Cyclin_N PF00134.23 EDO17947.1 - 0.00046 19.9 0.2 0.15 11.8 0.1 2.5 2 0 0 2 2 2 2 Cyclin, N-terminal domain RNA_polI_A14 PF08203.11 EDO17947.1 - 0.087 13.6 3.3 0.71 10.6 0.1 3.1 2 0 0 2 2 2 0 Yeast RNA polymerase I subunit RPA14 Fibrillarin PF01269.17 EDO17948.1 - 4.3e-107 356.4 0.0 5.5e-107 356.1 0.0 1.0 1 0 0 1 1 1 1 Fibrillarin GCD14 PF08704.10 EDO17948.1 - 1.3e-05 25.0 0.1 2.3e-05 24.2 0.1 1.3 1 1 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit FtsJ PF01728.19 EDO17948.1 - 0.0059 16.7 0.0 0.0075 16.4 0.0 1.2 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltr_RsmB-F PF01189.17 EDO17948.1 - 0.063 12.9 0.0 0.18 11.4 0.0 1.7 2 0 0 2 2 2 0 16S rRNA methyltransferase RsmB/F PCMT PF01135.19 EDO17948.1 - 0.099 12.4 0.0 0.16 11.7 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Steroid_dh PF02544.16 EDO17949.1 - 1.5e-32 112.7 11.1 1.5e-32 112.7 11.1 1.6 2 0 0 2 2 2 1 3-oxo-5-alpha-steroid 4-dehydrogenase Pkinase PF00069.25 EDO17950.1 - 4.8e-39 134.3 0.0 7.7e-22 77.9 0.0 3.0 2 2 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EDO17950.1 - 6.4e-15 55.1 0.0 3e-09 36.5 0.0 3.2 3 0 0 3 3 3 2 Protein tyrosine kinase Kinase-like PF14531.6 EDO17950.1 - 0.0077 15.6 0.0 2.7 7.2 0.0 2.3 2 0 0 2 2 2 2 Kinase-like FTA2 PF13095.6 EDO17950.1 - 0.015 14.9 0.0 0.29 10.7 0.0 2.2 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 EDO17950.1 - 0.029 14.3 0.0 0.049 13.5 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family HEAT PF02985.22 EDO17951.1 - 4.4e-22 76.3 4.1 0.00082 19.4 0.0 7.8 8 0 0 8 8 8 4 HEAT repeat HEAT_EZ PF13513.6 EDO17951.1 - 1.7e-19 69.9 1.3 2.4e-11 43.9 0.0 7.9 7 1 1 8 8 8 1 HEAT-like repeat HEAT_2 PF13646.6 EDO17951.1 - 1.4e-12 47.8 0.0 0.00026 21.3 0.0 6.5 6 1 1 7 7 7 3 HEAT repeats Cnd1 PF12717.7 EDO17951.1 - 1.1e-08 35.3 2.7 0.011 15.8 0.0 4.2 4 0 0 4 4 4 3 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 EDO17951.1 - 2.5e-07 29.6 6.8 0.006 15.2 0.0 4.7 3 2 0 4 4 4 2 Adaptin N terminal region IBN_N PF03810.19 EDO17951.1 - 2.5e-05 24.1 6.0 0.00052 19.9 0.3 4.5 3 1 0 3 3 3 1 Importin-beta N-terminal domain Vac14_Fab1_bd PF12755.7 EDO17951.1 - 7e-05 23.4 0.0 0.37 11.4 0.0 4.6 4 1 1 5 5 5 1 Vacuolar 14 Fab1-binding region Beta_helix_2 PF18835.1 EDO17951.1 - 0.16 11.7 0.2 0.44 10.3 0.2 1.7 1 0 0 1 1 1 0 Beta helix repeat of Inulin fructotransferase SH3_1 PF00018.28 EDO17952.1 - 4.5e-10 39.0 0.8 4.7e-09 35.7 0.0 2.7 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 EDO17952.1 - 0.016 15.0 0.0 0.048 13.5 0.0 1.9 1 0 0 1 1 1 0 Variant SH3 domain Orthopox_F14 PF06076.12 EDO17953.1 - 0.18 12.1 3.1 0.39 11.0 0.2 2.8 2 0 0 2 2 2 0 Orthopoxvirus F14 protein CHASE6_C PF17150.4 EDO17953.1 - 9.5 7.0 9.4 3.2 8.5 0.0 3.7 4 0 0 4 4 4 0 C-terminal domain of two-partite extracellular sensor domain Med2 PF11214.8 EDO17954.1 - 6.5e-35 119.3 8.6 6.5e-35 119.3 8.6 4.5 3 1 1 4 4 4 1 Mediator complex subunit 2 Utp14 PF04615.13 EDO17954.1 - 0.82 8.2 35.4 1.1 7.8 35.4 1.1 1 0 0 1 1 1 0 Utp14 protein DUF572 PF04502.13 EDO17954.1 - 1.7 8.2 33.4 2.9 7.4 33.4 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF572) PP2C PF00481.21 EDO17955.1 - 8e-74 248.5 0.1 3.4e-73 246.5 0.1 1.7 1 1 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 EDO17955.1 - 0.00043 20.2 0.2 0.0022 17.9 0.2 2.0 1 1 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) AAA PF00004.29 EDO17956.1 - 1.8e-40 138.4 0.0 3.1e-40 137.7 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EDO17956.1 - 2.4e-11 43.3 0.2 4.6e-11 42.3 0.2 1.5 1 0 0 1 1 1 1 AAA+ lid domain Prot_ATP_ID_OB PF16450.5 EDO17956.1 - 7.2e-10 38.7 0.0 1.4e-09 37.8 0.0 1.5 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_2 PF07724.14 EDO17956.1 - 7e-06 26.3 0.0 2e-05 24.7 0.0 1.7 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) DUF815 PF05673.13 EDO17956.1 - 1.7e-05 24.1 0.0 2.9e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_22 PF13401.6 EDO17956.1 - 2e-05 24.9 0.2 0.017 15.4 0.1 2.6 1 1 1 2 2 2 2 AAA domain AAA_5 PF07728.14 EDO17956.1 - 7.6e-05 22.7 0.0 0.00038 20.5 0.0 2.2 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EDO17956.1 - 0.00021 21.7 0.1 0.0022 18.4 0.1 2.2 1 1 0 1 1 1 1 AAA ATPase domain RuvB_N PF05496.12 EDO17956.1 - 0.0008 19.2 0.0 0.0018 18.1 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_28 PF13521.6 EDO17956.1 - 0.0036 17.6 0.0 0.0077 16.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EDO17956.1 - 0.0078 16.8 0.0 0.025 15.1 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_14 PF13173.6 EDO17956.1 - 0.011 15.8 0.0 0.024 14.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 EDO17956.1 - 0.013 15.7 0.0 0.031 14.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_3 PF07726.11 EDO17956.1 - 0.016 15.1 0.0 0.039 13.8 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) IstB_IS21 PF01695.17 EDO17956.1 - 0.018 14.8 0.0 0.036 13.8 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein TIP49 PF06068.13 EDO17956.1 - 0.025 13.8 0.1 0.053 12.7 0.1 1.5 1 1 0 1 1 1 0 TIP49 P-loop domain NTPase_1 PF03266.15 EDO17956.1 - 0.027 14.4 0.1 0.26 11.2 0.0 2.4 2 0 0 2 2 2 0 NTPase ATPase PF06745.13 EDO17956.1 - 0.038 13.3 0.1 0.47 9.7 0.1 2.2 1 1 1 2 2 2 0 KaiC RNA_helicase PF00910.22 EDO17956.1 - 0.045 14.1 0.0 0.1 13.0 0.0 1.7 1 0 0 1 1 1 0 RNA helicase AAA_25 PF13481.6 EDO17956.1 - 0.053 13.1 1.4 0.46 10.0 0.4 2.4 1 1 1 2 2 2 0 AAA domain Mg_chelatase PF01078.21 EDO17956.1 - 0.056 12.8 0.1 0.11 11.8 0.1 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI NACHT PF05729.12 EDO17956.1 - 0.092 12.7 0.1 0.59 10.0 0.1 2.1 1 1 1 2 2 2 0 NACHT domain Zeta_toxin PF06414.12 EDO17956.1 - 0.097 11.9 0.1 0.18 11.1 0.1 1.3 1 0 0 1 1 1 0 Zeta toxin ABC_tran PF00005.27 EDO17956.1 - 0.16 12.5 1.0 1.4 9.4 1.0 2.4 1 1 0 1 1 1 0 ABC transporter AAA_24 PF13479.6 EDO17956.1 - 0.24 11.1 2.3 0.28 10.9 0.3 2.3 2 1 0 2 2 2 0 AAA domain Pkinase PF00069.25 EDO17957.1 - 3.9e-63 213.3 0.2 8.1e-63 212.3 0.2 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO17957.1 - 3e-32 111.9 0.0 5.5e-32 111.1 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDO17957.1 - 1.1e-06 28.1 0.0 4.1e-05 23.1 0.0 2.5 2 0 0 2 2 2 1 Kinase-like FTA2 PF13095.6 EDO17957.1 - 6.2e-05 22.7 1.2 0.19 11.3 0.3 2.9 2 1 0 3 3 3 2 Kinetochore Sim4 complex subunit FTA2 Haspin_kinase PF12330.8 EDO17957.1 - 0.00031 19.8 0.1 0.00031 19.8 0.1 1.7 2 0 0 2 2 2 1 Haspin like kinase domain Pkinase_fungal PF17667.1 EDO17957.1 - 0.0033 16.3 0.0 0.0033 16.3 0.0 2.1 3 0 0 3 3 3 1 Fungal protein kinase Kdo PF06293.14 EDO17957.1 - 0.023 14.0 0.0 0.043 13.2 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EDO17957.1 - 0.11 12.4 0.0 0.21 11.4 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family PTS_2-RNA PF01885.16 EDO17959.1 - 7.8e-58 195.5 2.4 9.9e-58 195.2 2.4 1.1 1 0 0 1 1 1 1 RNA 2'-phosphotransferase, Tpt1 / KptA family CPL PF08144.11 EDO17961.1 - 1.1e-51 175.0 1.0 2.4e-47 160.9 0.0 4.7 3 2 2 5 5 5 1 CPL (NUC119) domain PUF PF00806.19 EDO17961.1 - 4.1e-08 32.5 2.9 0.27 11.0 0.0 5.5 6 0 0 6 6 6 3 Pumilio-family RNA binding repeat DUF4253 PF14062.6 EDO17961.1 - 0.051 13.7 0.0 0.12 12.6 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4253) RepA_C PF04796.12 EDO17961.1 - 0.11 12.5 0.0 0.28 11.2 0.0 1.6 1 0 0 1 1 1 0 Plasmid encoded RepA protein RRN3 PF05327.11 EDO17961.1 - 0.18 10.3 12.1 0.36 9.3 8.4 2.5 2 0 0 2 2 2 0 RNA polymerase I specific transcription initiation factor RRN3 SAC3 PF12209.8 EDO17961.1 - 1.1 9.4 7.8 7.7 6.8 0.1 5.1 3 1 2 5 5 5 0 Leucine permease transcriptional regulator helical domain CDC45 PF02724.14 EDO17961.1 - 2.4 6.3 17.7 3.9 5.7 17.7 1.3 1 0 0 1 1 1 0 CDC45-like protein SDA1 PF05285.12 EDO17961.1 - 5.6 6.3 31.6 9.8 5.5 31.6 1.3 1 0 0 1 1 1 0 SDA1 Sec20 PF03908.13 EDO17962.1 - 1.1e-28 99.0 2.6 1.1e-28 99.0 2.6 3.0 3 0 0 3 3 3 1 Sec20 ORC_WH_C PF18137.1 EDO17962.1 - 0.013 15.5 0.1 0.19 11.8 0.0 2.5 3 0 0 3 3 3 0 Origin recognition complex winged helix C-terminal CxC4 PF18717.1 EDO17962.1 - 0.051 13.4 1.6 0.094 12.6 0.1 2.0 2 0 0 2 2 2 0 CxC4 like cysteine cluster associated with KDZ transposases NeuB PF03102.14 EDO17963.1 - 0.078 12.4 0.1 3.7 6.9 0.0 2.3 2 1 0 2 2 2 0 NeuB family RNase_P_pop3 PF08228.11 EDO17964.1 - 1.6e-47 161.5 0.9 2e-47 161.2 0.9 1.1 1 0 0 1 1 1 1 RNase P subunit Pop3 WSC PF01822.19 EDO17965.1 - 3.2e-13 49.7 11.8 3.2e-13 49.7 11.8 2.2 2 0 0 2 2 2 1 WSC domain Adeno_E3_CR2 PF02439.15 EDO17965.1 - 2e-05 24.2 1.1 4.6e-05 23.1 1.1 1.5 1 0 0 1 1 1 1 Adenovirus E3 region protein CR2 SKG6 PF08693.10 EDO17965.1 - 7.6e-05 22.0 3.5 7.6e-05 22.0 3.5 2.5 3 0 0 3 3 1 1 Transmembrane alpha-helix domain Glycophorin_A PF01102.18 EDO17965.1 - 0.0027 17.9 0.3 0.0027 17.9 0.3 3.1 3 1 1 4 4 4 1 Glycophorin A EphA2_TM PF14575.6 EDO17965.1 - 0.012 16.5 0.0 0.096 13.6 0.0 2.5 3 0 0 3 3 3 0 Ephrin type-A receptor 2 transmembrane domain Syndecan PF01034.20 EDO17965.1 - 0.02 14.8 0.0 0.039 13.9 0.0 1.4 1 0 0 1 1 1 0 Syndecan domain DUF4448 PF14610.6 EDO17965.1 - 0.024 14.4 0.1 0.058 13.2 0.1 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF4448) Amnionless PF14828.6 EDO17965.1 - 0.028 13.2 1.6 0.074 11.9 1.3 1.8 1 1 1 2 2 2 0 Amnionless Stevor PF17410.2 EDO17965.1 - 0.071 12.6 3.4 0.11 12.0 2.9 1.6 1 1 0 1 1 1 0 Subtelomeric Variable Open Reading frame Yip1 PF04893.17 EDO17965.1 - 0.092 12.5 0.2 0.092 12.5 0.2 1.7 2 0 0 2 2 2 0 Yip1 domain DUF2755 PF10954.8 EDO17965.1 - 0.22 11.5 0.8 0.58 10.1 0.5 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2755) DUF2681 PF10883.8 EDO17965.1 - 0.23 11.9 0.0 0.51 10.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2681) RIFIN PF02009.16 EDO17965.1 - 0.32 10.8 4.5 0.71 9.7 4.5 1.5 1 1 0 1 1 1 0 Rifin Striatin PF08232.12 EDO17965.1 - 1.3 9.6 3.5 2.6 8.6 3.5 1.6 1 0 0 1 1 1 0 Striatin family PTP_tm PF18861.1 EDO17965.1 - 1.7 8.6 8.1 0.078 13.0 2.0 1.8 2 0 0 2 2 2 0 Transmembrane domain of protein tyrosine phosphatase, receptor type J rve PF00665.26 EDO17966.1 - 3.8e-12 46.4 0.2 9.2e-12 45.2 0.0 1.7 2 0 0 2 2 2 1 Integrase core domain rve_3 PF13683.6 EDO17966.1 - 0.0038 17.0 0.0 0.0085 15.9 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain DUF4306 PF14154.6 EDO17966.1 - 0.12 12.5 0.1 0.29 11.3 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4306) DUF1751 PF08551.10 EDO17967.1 - 3.5e-29 101.3 0.6 3.5e-29 101.3 0.6 2.5 3 0 0 3 3 3 1 Eukaryotic integral membrane protein (DUF1751) Rhomboid PF01694.22 EDO17967.1 - 0.025 14.6 6.1 0.086 12.8 6.1 1.9 1 1 0 1 1 1 0 Rhomboid family HLH PF00010.26 EDO17968.1 - 0.0023 17.8 1.4 0.0035 17.3 0.2 1.8 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain DUF3683 PF12447.8 EDO17968.1 - 0.016 15.3 0.9 0.37 10.9 0.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3683) DUF2299 PF10061.9 EDO17968.1 - 0.057 13.2 0.7 0.085 12.6 0.6 1.3 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2299) Oxidored_FMN PF00724.20 EDO17969.1 - 7.5e-138 459.5 0.0 8.7e-138 459.2 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family TPR_7 PF13176.6 EDO17970.1 - 0.00012 21.9 1.3 0.027 14.5 0.1 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 EDO17970.1 - 0.00012 22.3 1.8 0.002 18.4 0.0 2.7 3 0 0 3 3 3 1 Tetratricopeptide repeat GCIP PF13324.6 EDO17970.1 - 0.0024 17.5 3.1 0.0024 17.5 3.1 2.6 2 1 0 2 2 2 1 Grap2 and cyclin-D-interacting TPR_1 PF00515.28 EDO17970.1 - 0.0041 16.9 3.3 0.17 11.7 0.1 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 EDO17970.1 - 0.0045 17.0 2.0 0.16 12.2 0.0 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat HIP1_clath_bdg PF16515.5 EDO17970.1 - 0.02 15.5 1.2 0.02 15.5 1.2 3.3 3 0 0 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 TPR_8 PF13181.6 EDO17970.1 - 0.093 13.0 0.2 0.093 13.0 0.2 3.5 4 0 0 4 4 4 0 Tetratricopeptide repeat HBM PF16591.5 EDO17970.1 - 0.14 11.6 2.3 0.29 10.5 0.4 2.3 2 1 0 2 2 2 0 Helical bimodular sensor domain CDC45 PF02724.14 EDO17970.1 - 1.6 7.0 12.4 2.6 6.2 12.4 1.4 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 EDO17970.1 - 1.8 7.2 3.7 2.4 6.8 3.7 1.2 1 0 0 1 1 1 0 Presenilin UPF0121 PF03661.13 EDO17971.1 - 7.8e-29 100.8 13.0 1e-28 100.4 13.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0121) HSP70 PF00012.20 EDO17972.1 - 2.8e-261 868.0 11.1 3.2e-261 867.8 11.1 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EDO17972.1 - 5.5e-16 58.3 0.9 5.8e-15 54.9 0.0 2.3 3 0 0 3 3 3 1 MreB/Mbl protein FGGY_C PF02782.16 EDO17972.1 - 0.0038 17.0 0.0 0.014 15.2 0.0 2.0 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain DDR PF08841.10 EDO17972.1 - 0.0068 15.4 0.4 0.055 12.5 0.2 2.2 2 0 0 2 2 2 1 Diol dehydratase reactivase ATPase-like domain DDE_Tnp_ISL3 PF01610.17 EDO17972.1 - 0.17 11.6 4.0 0.34 10.6 0.4 2.6 2 1 0 2 2 2 0 Transposase DUF1451 PF07295.11 EDO17972.1 - 0.56 10.2 3.3 1.4 9.0 3.3 1.6 1 0 0 1 1 1 0 Zinc-ribbon containing domain Prominin PF05478.11 EDO17972.1 - 0.58 8.1 2.9 1.3 6.9 1.3 1.8 2 0 0 2 2 2 0 Prominin TMCO5 PF14992.6 EDO17972.1 - 1.3 8.5 8.4 2.7 7.5 8.4 1.4 1 0 0 1 1 1 0 TMCO5 family PMBR PF09373.10 EDO17972.1 - 1.5 9.1 0.0 1.5 9.1 0.0 2.8 4 0 0 4 4 4 0 Pseudomurein-binding repeat Tim17 PF02466.19 EDO17974.1 - 6.4e-40 136.0 1.5 7.8e-40 135.7 1.5 1.1 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family CbtA PF09490.10 EDO17974.1 - 0.063 13.0 0.1 3.4 7.4 0.0 2.1 2 0 0 2 2 2 0 Probable cobalt transporter subunit (CbtA) Serine_protease PF18405.1 EDO17974.1 - 0.11 11.7 0.0 0.16 11.1 0.0 1.2 1 0 0 1 1 1 0 Gammaproteobacterial serine protease Orf78 PF06024.12 EDO17975.1 - 4.1 7.7 5.9 0.81 10.0 0.3 2.7 3 0 0 3 3 3 0 Orf78 (ac78) DUF3600 PF12207.8 EDO17976.1 - 0.14 12.1 1.2 8.2 6.3 0.3 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF3600) YkuD_2 PF13645.6 EDO17976.1 - 8.4 5.8 12.6 11 5.4 1.8 2.7 1 1 3 4 4 4 0 L,D-transpeptidase catalytic domain Chitin_synth_1 PF01644.17 EDO17977.1 - 1.2e-70 236.7 0.5 2.1e-70 235.9 0.5 1.4 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_1N PF08407.11 EDO17977.1 - 1.4e-26 92.2 0.1 3.7e-26 90.9 0.1 1.8 1 0 0 1 1 1 1 Chitin synthase N-terminal Chitin_synth_2 PF03142.15 EDO17977.1 - 2.4e-19 69.4 9.9 1e-13 50.8 0.1 2.7 3 0 0 3 3 3 2 Chitin synthase Glyco_trans_2_3 PF13632.6 EDO17977.1 - 1.1e-10 41.7 0.7 1.1e-10 41.7 0.7 2.1 3 1 0 3 3 3 1 Glycosyl transferase family group 2 RTC4 PF14474.6 EDO17977.1 - 0.0016 18.6 0.0 0.0052 17.0 0.0 1.8 1 0 0 1 1 1 1 RTC4-like domain Glyco_tranf_2_3 PF13641.6 EDO17977.1 - 0.0047 16.8 0.0 0.0099 15.8 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 EDO17977.1 - 0.018 14.9 0.0 6.1 6.6 0.0 2.7 2 0 0 2 2 2 0 Glycosyl transferase family 2 CDC13_N PF16853.5 EDO17978.1 - 1.1e-61 208.0 8.8 1.1e-61 208.0 8.8 3.2 3 1 0 3 3 3 1 Cell division control protein 13 N-terminus Cdc13_OB2 PF18691.1 EDO17978.1 - 4.2e-43 145.9 1.1 4.2e-43 145.9 1.1 2.7 2 0 0 2 2 2 1 Cell division control protein 13, OB2 domain POT1 PF02765.17 EDO17978.1 - 4.7e-19 68.6 3.6 4.9e-19 68.6 0.6 2.6 2 0 0 2 2 2 1 Telomeric single stranded DNA binding POT1/CDC13 Cdc13_OB4_dimer PF18233.1 EDO17978.1 - 3e-11 43.5 4.3 3e-11 43.5 4.3 1.9 2 0 0 2 2 2 1 Cdc13 OB4 dimerization domain SUR7 PF06687.12 EDO17979.1 - 4.8e-36 124.4 8.8 6.5e-36 124.0 8.8 1.2 1 0 0 1 1 1 1 SUR7/PalI family DUF2768 PF10966.8 EDO17979.1 - 0.025 15.0 1.9 0.025 15.0 1.9 2.9 4 0 0 4 4 4 0 Protein of unknown function (DUF2768) RRM_1 PF00076.22 EDO17981.1 - 4.2e-20 71.3 0.0 5e-16 58.3 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF2828 PF11443.8 EDO17981.1 - 0.24 9.5 13.6 0.38 8.8 13.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) eIF-3_zeta PF05091.12 EDO17981.1 - 1.3 7.9 23.5 0.024 13.6 16.4 1.7 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) RR_TM4-6 PF06459.12 EDO17981.1 - 2 8.2 24.9 0.041 13.7 16.7 2.1 3 0 0 3 3 3 0 Ryanodine Receptor TM 4-6 NARP1 PF12569.8 EDO17981.1 - 3.4 6.5 17.5 5.1 5.9 17.5 1.2 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 LMBR1 PF04791.16 EDO17981.1 - 7.7 5.3 9.0 11 4.7 9.0 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein Septin PF00735.18 EDO17982.1 - 1.7e-72 244.1 9.4 3.9e-72 242.9 3.4 2.6 2 1 0 2 2 2 1 Septin NB-ARC PF00931.22 EDO17982.1 - 0.0014 17.9 0.8 0.0072 15.5 0.0 2.1 2 0 0 2 2 2 1 NB-ARC domain AAA_24 PF13479.6 EDO17982.1 - 0.0057 16.4 0.0 0.092 12.5 0.0 2.3 2 0 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 EDO17982.1 - 0.0077 16.2 0.2 0.14 12.1 0.0 2.5 2 0 0 2 2 2 1 RsgA GTPase AAA_22 PF13401.6 EDO17982.1 - 0.0089 16.3 1.0 0.03 14.6 0.0 2.4 3 1 0 3 3 3 1 AAA domain AIG1 PF04548.16 EDO17982.1 - 0.0097 15.2 0.2 0.0097 15.2 0.2 2.3 2 0 0 2 2 2 1 AIG1 family AAA_33 PF13671.6 EDO17982.1 - 0.016 15.4 0.0 0.043 14.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 EDO17982.1 - 0.031 14.3 0.5 0.15 12.2 0.5 2.3 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_18 PF13238.6 EDO17982.1 - 0.033 14.7 3.2 0.036 14.6 0.1 2.6 2 2 0 2 2 2 0 AAA domain DUF5395 PF17373.2 EDO17982.1 - 0.038 14.6 0.1 1.5 9.5 0.1 2.8 2 0 0 2 2 2 0 Family of unknown function (DUF5395) RNA_helicase PF00910.22 EDO17982.1 - 0.046 14.1 0.0 0.28 11.6 0.0 2.3 2 0 0 2 2 2 0 RNA helicase Pox_A32 PF04665.12 EDO17982.1 - 0.05 13.1 0.0 0.11 12.0 0.0 1.5 1 0 0 1 1 1 0 Poxvirus A32 protein Synaptobrevin PF00957.21 EDO17982.1 - 0.066 13.0 1.4 0.28 11.0 1.4 2.1 1 0 0 1 1 1 0 Synaptobrevin Roc PF08477.13 EDO17982.1 - 0.083 13.1 0.0 0.21 11.8 0.0 1.7 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_7 PF12775.7 EDO17982.1 - 0.09 12.3 0.1 0.2 11.2 0.1 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA PF00004.29 EDO17982.1 - 0.098 13.1 0.3 0.4 11.1 0.0 2.2 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Bap31_Bap29_C PF18035.1 EDO17983.1 - 0.062 13.3 3.0 0.35 10.9 0.9 2.3 1 1 1 2 2 2 0 Bap31/Bap29 cytoplasmic coiled-coil domain DUF5102 PF17104.5 EDO17983.1 - 0.23 11.5 3.1 0.4 10.7 3.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5102) adh_short_C2 PF13561.6 EDO17984.1 - 7.3e-43 146.8 0.0 8.4e-43 146.6 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EDO17984.1 - 2.8e-32 111.8 0.1 3.7e-32 111.4 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EDO17984.1 - 2.1e-07 31.0 0.3 1.5e-06 28.3 0.0 2.1 3 0 0 3 3 3 1 KR domain Epimerase PF01370.21 EDO17984.1 - 0.066 12.7 0.0 0.099 12.1 0.0 1.2 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Hom_end_hint PF05203.16 EDO17985.1 - 1.4e-49 169.1 0.0 1.7e-49 168.8 0.0 1.0 1 0 0 1 1 1 1 Hom_end-associated Hint Hom_end PF05204.14 EDO17985.1 - 9.2e-45 151.3 0.0 6.7e-37 126.0 0.0 2.5 2 0 0 2 2 2 2 Homing endonuclease LAGLIDADG_3 PF14528.6 EDO17985.1 - 4.5e-11 42.9 0.0 3e-06 27.5 0.0 2.6 2 0 0 2 2 2 2 LAGLIDADG-like domain HSP70 PF00012.20 EDO17986.1 - 5.9e-229 761.2 9.9 6.6e-229 761.1 9.9 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EDO17986.1 - 1.2e-16 60.5 1.2 3e-15 55.9 0.5 2.2 2 0 0 2 2 2 2 MreB/Mbl protein FGGY_C PF02782.16 EDO17986.1 - 0.0004 20.2 0.0 0.00083 19.1 0.0 1.5 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FtsA PF14450.6 EDO17986.1 - 2 8.9 9.4 5.2 7.5 0.1 3.7 3 3 0 3 3 3 0 Cell division protein FtsA Y_phosphatase PF00102.27 EDO17987.1 - 9.3e-54 182.5 1.6 2.5e-53 181.1 1.6 1.7 1 1 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 EDO17987.1 - 0.00018 21.3 0.0 0.00035 20.4 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 EDO17987.1 - 0.11 12.5 0.0 0.22 11.4 0.0 1.6 1 1 0 1 1 1 0 Tyrosine phosphatase family Ost4 PF10215.9 EDO17988.1 - 3.4e-13 49.2 6.5 3.8e-13 49.0 6.5 1.0 1 0 0 1 1 1 1 Oligosaccaryltransferase VID27 PF08553.10 EDO17989.1 - 3.9e-143 476.8 1.2 6.1e-143 476.2 1.2 1.3 1 0 0 1 1 1 1 VID27 C-terminal WD40-like domain VID27_PH PF17747.1 EDO17989.1 - 4.1e-23 81.7 5.9 9.2e-23 80.6 5.9 1.6 1 0 0 1 1 1 1 VID27 PH-like domain NTPase_P4 PF11602.8 EDO17989.1 - 0.076 12.2 0.0 0.18 11.0 0.0 1.6 1 0 0 1 1 1 0 ATPase P4 of dsRNA bacteriophage phi-12 Neugrin PF06413.11 EDO17990.1 - 6.5e-07 29.6 2.3 1.1e-06 28.8 2.3 1.5 1 1 0 1 1 1 1 Neugrin HTH_11 PF08279.12 EDO17990.1 - 0.0062 16.5 0.0 0.018 15.0 0.0 1.8 1 0 0 1 1 1 1 HTH domain Sigma70_r4 PF04545.16 EDO17990.1 - 0.02 14.4 0.0 0.047 13.2 0.0 1.7 1 0 0 1 1 1 0 Sigma-70, region 4 HTH_3 PF01381.22 EDO17990.1 - 0.03 14.4 0.0 0.077 13.1 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix DUF438 PF04282.13 EDO17990.1 - 0.1 12.5 0.5 0.42 10.6 0.1 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF438) RED_C PF07807.11 EDO17990.1 - 0.29 11.6 2.6 0.86 10.1 0.1 2.4 2 0 0 2 2 2 0 RED-like protein C-terminal region Seryl_tRNA_N PF02403.22 EDO17990.1 - 0.64 10.3 9.2 0.41 10.9 3.0 2.7 2 1 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain PAPA-1 PF04795.12 EDO17992.1 - 8.1e-22 77.8 4.8 8.1e-22 77.8 4.8 3.6 3 1 0 3 3 3 1 PAPA-1-like conserved region DUF966 PF06136.13 EDO17992.1 - 1.1 8.9 23.0 1.6 8.4 23.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF966) Atg14 PF10186.9 EDO17992.1 - 3.2 6.8 8.9 4.9 6.2 8.9 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Rap1-DNA-bind PF09197.10 EDO17993.1 - 3.5e-47 159.5 13.6 5.2e-45 152.5 0.5 3.4 2 1 0 2 2 2 2 Rap1, DNA-binding Rap1_C PF11626.8 EDO17993.1 - 1.5e-24 85.9 0.0 5.4e-23 80.9 0.0 3.4 4 0 0 4 4 4 1 TRF2-interacting telomeric protein/Rap1 - C terminal domain BRCT_2 PF16589.5 EDO17993.1 - 1.7e-19 70.0 2.4 2.9e-19 69.2 0.5 2.5 3 0 0 3 3 3 1 BRCT domain, a BRCA1 C-terminus domain Myb_DNA-binding PF00249.31 EDO17993.1 - 4.4e-15 55.6 0.0 1.9e-11 43.9 0.0 3.9 4 0 0 4 4 4 1 Myb-like DNA-binding domain Myb_DNA-bind_2 PF08914.11 EDO17993.1 - 4.3e-09 36.4 0.3 6.2e-05 23.1 0.0 2.7 2 0 0 2 2 2 2 Rap1 Myb domain BRCT PF00533.26 EDO17993.1 - 0.015 15.7 2.0 0.059 13.8 0.1 3.0 3 0 0 3 3 3 0 BRCA1 C Terminus (BRCT) domain Myb_DNA-bind_6 PF13921.6 EDO17993.1 - 0.045 14.0 1.4 0.34 11.2 0.0 3.1 4 0 0 4 4 4 0 Myb-like DNA-binding domain SLIDE PF09111.10 EDO17993.1 - 0.051 13.6 0.2 0.051 13.6 0.2 3.0 4 0 0 4 4 4 0 SLIDE Hpt PF01627.23 EDO17994.1 - 1.8e-11 44.1 0.1 2.8e-11 43.5 0.1 1.4 1 1 0 1 1 1 1 Hpt domain Hydrolase_6 PF13344.6 EDO17995.1 - 1.6e-26 92.4 0.0 3e-26 91.5 0.0 1.5 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EDO17995.1 - 3.4e-16 59.1 0.0 5.5e-16 58.4 0.0 1.3 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.26 EDO17995.1 - 6.2e-16 59.3 0.0 1e-15 58.6 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 EDO17995.1 - 5.6e-07 29.8 0.1 0.0017 18.4 0.0 2.4 2 1 0 2 2 2 2 Haloacid dehalogenase-like hydrolase Adenylsucc_synt PF00709.21 EDO17996.1 - 1.2e-177 591.0 0.0 1.4e-177 590.8 0.0 1.0 1 0 0 1 1 1 1 Adenylosuccinate synthetase POP1 PF06978.11 EDO17997.1 - 7.6e-74 248.1 10.3 7.6e-74 248.1 10.3 2.1 2 0 0 2 2 2 1 Ribonucleases P/MRP protein subunit POP1 POPLD PF08170.12 EDO17997.1 - 3.8e-34 116.9 1.0 1.1e-33 115.5 1.0 1.8 1 0 0 1 1 1 1 POPLD (NUC188) domain GCV_T_C PF08669.11 EDO17997.1 - 0.015 15.2 0.0 0.03 14.2 0.0 1.4 1 0 0 1 1 1 0 Glycine cleavage T-protein C-terminal barrel domain Amidohydro_1 PF01979.20 EDO17999.1 - 6.2e-80 269.1 0.0 7.3e-80 268.9 0.0 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 EDO17999.1 - 3.8e-07 29.9 0.1 0.0001 21.9 0.0 2.1 2 0 0 2 2 2 2 Amidohydrolase family Ssu72 PF04722.13 EDO18000.1 - 1.5e-82 275.8 0.1 1.7e-82 275.6 0.1 1.0 1 0 0 1 1 1 1 Ssu72-like protein NYN_YacP PF05991.11 EDO18000.1 - 0.036 14.0 0.0 0.051 13.5 0.0 1.4 1 0 0 1 1 1 0 YacP-like NYN domain HLH PF00010.26 EDO18001.1 - 3.6e-13 49.3 3.8 7e-13 48.3 3.8 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Macoilin PF09726.9 EDO18001.1 - 0.91 8.0 33.5 1.4 7.4 33.5 1.3 1 1 0 1 1 1 0 Macoilin family LicD PF04991.13 EDO18002.1 - 6.8e-55 186.7 1.7 6.8e-55 186.7 1.7 2.3 2 0 0 2 2 2 1 LicD family DPPIV_rep PF18811.1 EDO18002.1 - 0.062 13.3 0.5 23 5.1 0.1 3.3 2 0 0 2 2 2 0 Dipeptidyl peptidase IV (DPP IV) low complexity region Cpn60_TCP1 PF00118.24 EDO18003.1 - 5.9e-150 500.1 3.1 6.8e-150 499.9 3.1 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family DUF3437 PF11919.8 EDO18004.1 - 0.074 13.0 0.0 0.19 11.7 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3437) DUF2777 PF10949.8 EDO18004.1 - 0.12 12.0 0.8 0.33 10.6 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2777) DUF4895 PF16236.5 EDO18005.1 - 0.026 14.3 4.8 0.073 12.8 0.0 3.0 2 1 1 3 3 3 0 Domain of unknown function (DUF4895) HEAT_2 PF13646.6 EDO18006.1 - 2e-31 108.2 1.2 4.1e-16 59.2 0.0 3.0 2 1 1 3 3 3 2 HEAT repeats HEAT_PBS PF03130.16 EDO18006.1 - 1.1e-16 59.7 0.1 0.0023 18.4 0.0 6.1 6 0 0 6 6 6 3 PBS lyase HEAT-like repeat HEAT PF02985.22 EDO18006.1 - 5.4e-10 38.7 0.5 0.27 11.6 0.0 5.3 5 0 0 5 5 5 3 HEAT repeat HEAT_EZ PF13513.6 EDO18006.1 - 0.00054 20.4 3.0 1.7 9.3 0.1 4.5 3 2 1 4 4 4 2 HEAT-like repeat Arm PF00514.23 EDO18006.1 - 0.0014 18.6 0.1 0.062 13.4 0.0 2.9 3 0 0 3 3 3 1 Armadillo/beta-catenin-like repeat PEMT PF04191.13 EDO18007.1 - 1.3e-35 122.0 2.4 1.3e-35 122.0 2.4 1.8 2 0 0 2 2 2 1 Phospholipid methyltransferase Phage_tail_NK PF16532.5 EDO18007.1 - 0.064 12.9 0.3 0.1 12.2 0.3 1.3 1 0 0 1 1 1 0 Sf6-type phage tail needle knob or tip of some Caudovirales ThiF PF00899.21 EDO18008.1 - 6.4e-111 369.5 0.0 1.7e-77 260.1 0.0 2.3 2 0 0 2 2 2 2 ThiF family UBA_e1_thiolCys PF10585.9 EDO18008.1 - 4e-88 295.6 0.1 5.9e-88 295.0 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin-activating enzyme active site E1_UFD PF09358.10 EDO18008.1 - 2.2e-33 114.8 0.1 6.4e-33 113.3 0.1 1.9 1 0 0 1 1 1 1 Ubiquitin fold domain E1_FCCH PF16190.5 EDO18008.1 - 1.3e-24 86.1 0.1 3.6e-24 84.8 0.1 1.8 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 FCCH domain E1_4HB PF16191.5 EDO18008.1 - 1.5e-22 79.6 0.7 4.7e-22 78.0 0.7 2.0 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 four-helix bundle Mog1 PF04603.12 EDO18009.1 - 4.7e-41 140.4 0.1 5.7e-41 140.1 0.1 1.1 1 0 0 1 1 1 1 Ran-interacting Mog1 protein Thr_dehydrat_C PF00585.18 EDO18009.1 - 0.066 13.0 0.0 0.11 12.3 0.0 1.4 1 0 0 1 1 1 0 C-terminal regulatory domain of Threonine dehydratase Gly_transf_sug PF04488.15 EDO18010.1 - 1.4e-10 41.7 0.1 4.2e-10 40.1 0.1 1.8 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif SlyX PF04102.12 EDO18010.1 - 0.009 16.6 2.9 0.017 15.7 1.5 2.0 2 0 0 2 2 2 1 SlyX Flavodoxin_3 PF12641.7 EDO18010.1 - 0.055 13.2 0.0 0.097 12.4 0.0 1.4 1 0 0 1 1 1 0 Flavodoxin domain TRAF_BIRC3_bd PF16673.5 EDO18010.1 - 0.84 9.5 7.2 0.23 11.2 0.5 2.4 1 1 1 2 2 2 0 TNF receptor-associated factor BIRC3 binding domain Syja_N PF02383.18 EDO18011.1 - 2.4e-82 276.9 0.7 3.5e-82 276.3 0.7 1.2 1 0 0 1 1 1 1 SacI homology domain GA-like PF17573.2 EDO18011.1 - 0.083 12.8 0.3 15 5.6 0.0 2.5 2 0 0 2 2 2 0 GA-like domain PFU PF09070.11 EDO18012.1 - 1.5e-40 138.0 0.1 3.4e-40 136.8 0.1 1.6 1 0 0 1 1 1 1 PFU (PLAA family ubiquitin binding) PUL PF08324.11 EDO18012.1 - 2.8e-40 138.3 0.5 3.7e-40 137.9 0.5 1.2 1 0 0 1 1 1 1 PUL domain WD40 PF00400.32 EDO18012.1 - 3.7e-29 100.3 21.8 4.6e-07 30.4 0.1 7.6 8 0 0 8 8 8 6 WD domain, G-beta repeat BBS2_Mid PF14783.6 EDO18012.1 - 1.9e-05 24.6 1.0 0.28 11.2 0.1 4.2 4 1 1 5 5 5 2 Ciliary BBSome complex subunit 2, middle region ANAPC4_WD40 PF12894.7 EDO18012.1 - 0.00016 21.9 0.9 0.079 13.3 0.1 3.5 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EDO18012.1 - 0.076 11.7 2.2 1.8 7.1 0.1 2.7 2 1 1 3 3 3 0 Nucleoporin Nup120/160 Hydantoinase_B PF02538.14 EDO18013.1 - 2.2e-200 666.5 0.0 2.7e-200 666.2 0.0 1.1 1 0 0 1 1 1 1 Hydantoinase B/oxoprolinase Hydantoinase_A PF01968.18 EDO18013.1 - 3.1e-101 338.5 0.0 7.4e-101 337.2 0.0 1.7 2 0 0 2 2 2 1 Hydantoinase/oxoprolinase Hydant_A_N PF05378.13 EDO18013.1 - 3e-58 196.5 0.0 1.8e-56 190.6 0.0 2.5 2 0 0 2 2 2 1 Hydantoinase/oxoprolinase N-terminal region Flocculin PF00624.18 EDO18014.1 - 1.3e-230 745.4 659.0 2.1e-11 43.8 12.7 30.4 30 1 0 30 30 30 27 Flocculin repeat Endothelin PF00322.17 EDO18014.1 - 4.9e-06 26.0 0.0 2.3e+02 1.5 0.0 8.6 8 0 0 8 8 8 0 Endothelin family Ribonuclease_T2 PF00445.18 EDO18014.1 - 0.074 13.3 0.7 0.25 11.5 0.7 1.9 1 0 0 1 1 1 0 Ribonuclease T2 family ComC PF03047.14 EDO18014.1 - 0.09 12.6 0.3 0.27 11.1 0.3 1.8 1 0 0 1 1 1 0 COMC family DUF2011 PF09428.10 EDO18014.1 - 0.8 10.0 50.7 16 5.8 0.3 11.4 9 8 3 12 12 12 0 Fungal protein of unknown function (DUF2011) RB_B PF01857.20 EDO18015.1 - 0.0057 16.7 0.1 15 5.6 0.0 7.1 7 4 0 7 7 7 1 Retinoblastoma-associated protein B domain TPT PF03151.16 EDO18017.1 - 9.4e-25 87.5 16.3 2.4e-22 79.7 16.3 2.6 1 1 0 1 1 1 1 Triose-phosphate Transporter family UAA PF08449.11 EDO18017.1 - 0.00018 20.8 14.2 0.018 14.3 3.1 2.1 2 0 0 2 2 2 2 UAA transporter family DUF4395 PF14340.6 EDO18017.1 - 0.009 16.4 1.6 1.5 9.2 0.3 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF4395) EamA PF00892.20 EDO18017.1 - 0.82 9.8 23.4 8.5 6.5 14.7 3.0 2 1 0 2 2 2 0 EamA-like transporter family DUF2583 PF10762.9 EDO18017.1 - 4.5 7.8 6.3 2.3 8.7 1.2 2.7 3 1 0 3 3 3 0 Protein of unknown function (DUF2583) Mito_carr PF00153.27 EDO18018.1 - 2e-30 104.5 5.7 2.7e-12 46.5 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein MFS_1 PF07690.16 EDO18019.1 - 2.8e-26 92.3 43.3 5.3e-19 68.4 22.0 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EDO18019.1 - 1.3e-06 27.6 33.6 0.0012 17.7 20.6 2.9 1 1 1 2 2 2 2 Sugar (and other) transporter DUF2034 PF10356.9 EDO18020.1 - 1.6e-52 177.7 0.3 1.9e-52 177.4 0.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2034) Mrr_cat PF04471.12 EDO18020.1 - 9.5e-05 22.4 0.0 0.022 14.8 0.0 2.4 2 0 0 2 2 2 2 Restriction endonuclease Cauli_AT PF03233.13 EDO18021.1 - 0.053 13.5 1.9 0.056 13.4 1.9 1.0 1 0 0 1 1 1 0 Aphid transmission protein ORF6N PF10543.9 EDO18021.1 - 0.065 13.4 0.1 0.086 13.1 0.1 1.1 1 0 0 1 1 1 0 ORF6N domain RNase_3_N PF18497.1 EDO18022.1 - 5.1e-45 152.1 3.3 5.1e-45 152.1 3.3 1.9 2 0 0 2 2 2 1 Ribonuclease III N-terminal domain Ribonuclease_3 PF00636.26 EDO18022.1 - 1e-16 61.4 0.0 3.8e-16 59.6 0.0 2.0 1 0 0 1 1 1 1 Ribonuclease III domain Ribonucleas_3_3 PF14622.6 EDO18022.1 - 7.6e-13 48.7 0.0 1.5e-12 47.8 0.0 1.5 1 0 0 1 1 1 1 Ribonuclease-III-like dsrm PF00035.26 EDO18022.1 - 2.2e-05 25.0 0.0 7.2e-05 23.4 0.0 1.9 2 0 0 2 2 2 1 Double-stranded RNA binding motif Mustang PF15682.5 EDO18022.1 - 0.061 13.4 0.0 0.3 11.2 0.0 2.2 2 0 0 2 2 2 0 Musculoskeletal, temporally activated-embryonic nuclear protein 1 Phage_int_SAM_3 PF14659.6 EDO18022.1 - 0.2 11.9 2.3 1.7 9.0 0.0 3.6 3 1 0 3 3 3 0 Phage integrase, N-terminal SAM-like domain RCC1 PF00415.18 EDO18023.1 - 1.7e-22 79.8 1.4 1.6e-11 44.6 0.0 4.9 4 0 0 4 4 4 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EDO18023.1 - 1.9e-15 56.2 1.6 6.5e-06 25.8 0.0 3.7 3 0 0 3 3 3 3 Regulator of chromosome condensation (RCC1) repeat BTB PF00651.31 EDO18023.1 - 1.8e-09 37.8 0.8 1.4e-07 31.7 0.0 3.3 3 0 0 3 3 3 1 BTB/POZ domain CAC1F_C PF16885.5 EDO18023.1 - 0.94 9.1 7.8 2 8.0 7.8 1.5 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term Flocculin PF00624.18 EDO18024.1 - 1.7e-68 226.6 356.0 4.9e-11 42.7 13.9 19.8 19 2 0 19 19 19 16 Flocculin repeat ATP-synt_ab PF00006.25 EDO18025.1 - 8.9e-71 237.9 0.0 1.3e-70 237.4 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.27 EDO18025.1 - 3.1e-46 156.8 0.7 5.2e-46 156.1 0.7 1.4 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.23 EDO18025.1 - 2.9e-16 59.8 1.7 8e-16 58.3 1.7 1.8 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain Tex_N PF09371.10 EDO18025.1 - 0.11 12.1 0.0 0.3 10.7 0.0 1.7 1 0 0 1 1 1 0 Tex-like protein N-terminal domain Cyclin_C_2 PF16899.5 EDO18026.1 - 3e-29 101.4 0.3 9.1e-29 99.9 0.1 1.9 2 0 0 2 2 2 1 Cyclin C-terminal domain Cyclin_N PF00134.23 EDO18026.1 - 4.6e-10 39.3 2.0 1.6e-09 37.6 0.7 2.2 2 0 0 2 2 2 1 Cyclin, N-terminal domain TFIIB PF00382.19 EDO18026.1 - 0.027 14.5 0.0 0.15 12.1 0.0 2.1 2 0 0 2 2 2 0 Transcription factor TFIIB repeat Peptidase_M41 PF01434.18 EDO18027.1 - 3.7e-57 193.3 0.1 6.1e-57 192.6 0.1 1.3 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 EDO18027.1 - 6.9e-39 133.3 0.0 2e-38 131.8 0.0 1.9 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EDO18027.1 - 8e-11 41.6 0.0 2.1e-10 40.2 0.0 1.7 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 EDO18027.1 - 0.00012 22.5 0.1 0.00043 20.7 0.1 1.9 1 1 0 1 1 1 1 AAA ATPase domain TIP49 PF06068.13 EDO18027.1 - 0.00015 21.1 0.0 0.00032 20.0 0.0 1.5 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_22 PF13401.6 EDO18027.1 - 0.00053 20.3 1.0 0.045 14.0 0.1 2.8 3 0 0 3 3 2 1 AAA domain RuvB_N PF05496.12 EDO18027.1 - 0.0006 19.6 0.0 0.0027 17.5 0.0 2.0 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 EDO18027.1 - 0.0019 18.2 0.0 0.0065 16.5 0.0 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.17 EDO18027.1 - 0.026 14.2 0.0 0.05 13.3 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein ATPase PF06745.13 EDO18027.1 - 0.029 13.7 0.2 0.21 10.9 0.1 2.4 2 0 0 2 2 2 0 KaiC AAA_2 PF07724.14 EDO18027.1 - 0.035 14.2 0.0 0.11 12.7 0.0 1.9 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) AAA_14 PF13173.6 EDO18027.1 - 0.036 14.1 0.0 0.13 12.3 0.0 2.0 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 EDO18027.1 - 0.04 14.4 0.0 0.11 13.0 0.0 1.8 1 0 0 1 1 1 0 AAA domain DUF2075 PF09848.9 EDO18027.1 - 0.067 12.4 0.3 0.13 11.5 0.0 1.6 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) Mg_chelatase PF01078.21 EDO18027.1 - 0.097 12.0 0.2 0.2 11.0 0.2 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_24 PF13479.6 EDO18027.1 - 0.098 12.4 0.0 0.23 11.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 EDO18027.1 - 0.099 12.1 0.4 0.41 10.1 0.3 2.0 2 0 0 2 2 2 0 PhoH-like protein AAA_28 PF13521.6 EDO18027.1 - 0.11 12.7 0.1 0.29 11.4 0.1 1.7 1 0 0 1 1 1 0 AAA domain FAD_binding_3 PF01494.19 EDO18028.1 - 5.1e-18 65.4 0.0 1.9e-17 63.5 0.0 1.8 1 1 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 EDO18028.1 - 2.5e-05 24.4 0.0 6e-05 23.2 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EDO18028.1 - 5.5e-05 22.9 0.0 0.00038 20.1 0.0 2.0 2 0 0 2 2 2 1 FAD dependent oxidoreductase ApbA PF02558.16 EDO18028.1 - 0.00065 19.4 0.0 0.0012 18.5 0.0 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA Pyr_redox_2 PF07992.14 EDO18028.1 - 0.00098 18.4 0.0 0.0013 18.0 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EDO18028.1 - 0.00099 19.6 0.1 0.006 17.1 0.0 2.3 3 0 0 3 3 2 1 Pyridine nucleotide-disulphide oxidoreductase SE PF08491.10 EDO18028.1 - 0.0021 17.1 0.0 0.0068 15.5 0.0 1.8 2 0 0 2 2 2 1 Squalene epoxidase UDPG_MGDP_dh_N PF03721.14 EDO18028.1 - 0.0085 15.7 0.0 0.014 14.9 0.0 1.3 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 3HCDH_N PF02737.18 EDO18028.1 - 0.019 14.9 0.0 0.032 14.1 0.0 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Glu_dehyd_C PF16912.5 EDO18028.1 - 0.21 11.1 0.0 0.34 10.3 0.0 1.4 1 0 0 1 1 1 0 Glucose dehydrogenase C-terminus GIDA PF01134.22 EDO18028.1 - 0.23 10.5 0.0 0.34 9.9 0.0 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A Cnd2 PF05786.14 EDO18029.1 - 1.5e-129 433.9 42.3 2.4e-129 433.3 42.3 1.2 1 0 0 1 1 1 1 Condensin complex subunit 2 CNDH2_N PF06278.11 EDO18029.1 - 0.00051 20.2 2.4 0.0058 16.8 0.0 3.3 2 0 0 2 2 2 1 Condensin II complex subunit CAP-H2 or CNDH2, N-terminal DTHCT PF08070.11 EDO18029.1 - 4 8.2 12.5 0.82 10.4 4.8 2.9 2 0 0 2 2 2 0 DTHCT (NUC029) region Rox3 PF08633.10 EDO18030.1 - 1.2e-36 127.0 1.2 1.5e-36 126.7 1.2 1.1 1 0 0 1 1 1 1 Rox3 mediator complex subunit Motile_Sperm PF00635.26 EDO18031.1 - 1.3e-19 70.0 0.0 2e-19 69.4 0.0 1.3 1 0 0 1 1 1 1 MSP (Major sperm protein) domain TMEM131_like PF12371.8 EDO18031.1 - 1.2e-05 25.5 0.1 2.3e-05 24.6 0.1 1.4 1 0 0 1 1 1 1 Transmembrane protein 131-like ASH PF15780.5 EDO18031.1 - 0.014 15.6 1.3 0.045 14.0 0.3 2.0 2 0 0 2 2 2 0 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin DUF2117 PF09890.9 EDO18031.1 - 0.1 12.0 0.1 4 6.8 0.0 2.2 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2117) Peptidase_M24 PF00557.24 EDO18032.1 - 8.3e-42 143.2 0.0 9.9e-42 143.0 0.0 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 Ribosomal_S21 PF01165.20 EDO18033.1 - 2.3e-12 46.4 0.5 3.9e-12 45.7 0.5 1.4 1 0 0 1 1 1 1 Ribosomal protein S21 PCEMA1 PF07418.11 EDO18033.1 - 0.022 14.3 0.0 0.026 14.1 0.0 1.0 1 0 0 1 1 1 0 Acidic phosphoprotein precursor PCEMA1 Aa_trans PF01490.18 EDO18034.1 - 1.9e-112 375.9 24.3 2.4e-112 375.7 24.3 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 EDO18034.1 - 2.8e-07 29.9 16.9 2.8e-07 29.9 16.9 1.7 2 0 0 2 2 2 1 Tryptophan/tyrosine permease family SH3_1 PF00018.28 EDO18035.1 - 2.6e-10 39.8 0.2 4.7e-10 38.9 0.2 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EDO18035.1 - 2e-08 34.0 0.1 3.7e-08 33.1 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EDO18035.1 - 6.2e-06 25.8 0.0 1.4e-05 24.7 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain TctB PF07331.11 EDO18035.1 - 0.026 14.8 3.2 0.038 14.2 3.2 1.2 1 0 0 1 1 1 0 Tripartite tricarboxylate transporter TctB family PI3_PI4_kinase PF00454.27 EDO18036.1 - 1.5e-61 208.4 0.2 1.5e-60 205.1 0.0 3.0 4 0 0 4 4 4 1 Phosphatidylinositol 3- and 4-kinase TAN PF11640.8 EDO18036.1 - 6.1e-24 84.9 3.2 6.1e-24 84.9 3.2 3.7 3 0 0 3 3 3 1 Telomere-length maintenance and DNA damage repair FATC PF02260.20 EDO18036.1 - 1.2e-09 37.9 0.0 2.7e-09 36.7 0.0 1.7 1 0 0 1 1 1 1 FATC domain ERp29 PF07749.12 EDO18036.1 - 4 8.4 9.3 12 6.9 0.1 3.6 3 0 0 3 3 3 0 Endoplasmic reticulum protein ERp29, C-terminal domain Ribosomal_L14 PF00238.19 EDO18037.1 - 1.3e-32 112.5 0.0 1.5e-32 112.2 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e zf-C3HC4 PF00097.25 EDO18038.1 - 3e-09 36.6 6.2 4.5e-09 36.0 6.2 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EDO18038.1 - 5.4e-09 35.8 4.7 8.1e-09 35.2 4.7 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EDO18038.1 - 4.2e-08 33.0 6.0 6.4e-08 32.4 6.0 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EDO18038.1 - 2.8e-07 30.4 4.7 5.4e-07 29.5 4.7 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.6 EDO18038.1 - 2.3e-06 27.8 6.4 3.6e-06 27.2 6.4 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EDO18038.1 - 9.2e-06 25.4 6.4 1.9e-05 24.4 6.5 1.6 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EDO18038.1 - 9.7e-06 25.4 5.7 3.1e-05 23.7 5.9 1.8 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 EDO18038.1 - 0.0024 18.0 8.0 0.0044 17.1 8.0 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_11 PF17123.5 EDO18038.1 - 0.046 13.5 2.0 0.16 11.7 2.0 2.0 1 1 0 1 1 1 0 RING-like zinc finger DUF2616 PF11077.8 EDO18038.1 - 0.052 13.3 0.4 0.066 12.9 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2616) YceD PF02620.17 EDO18038.1 - 4.2 7.5 10.5 1.8 8.7 6.1 2.2 2 1 0 2 2 2 0 Large ribosomal RNA subunit accumulation protein YceD NT-C2 PF10358.9 EDO18040.1 - 1.2e-36 125.7 2.7 1.7e-36 125.1 2.7 1.3 1 0 0 1 1 1 1 N-terminal C2 in EEIG1 and EHBP1 proteins PH PF00169.29 EDO18041.1 - 4.9e-21 75.2 0.2 2.3e-19 69.9 0.0 2.7 2 0 0 2 2 2 1 PH domain SH3_1 PF00018.28 EDO18041.1 - 1.6e-13 50.0 0.2 3.4e-13 49.0 0.2 1.6 1 0 0 1 1 1 1 SH3 domain SAM_2 PF07647.17 EDO18041.1 - 4e-13 49.3 0.1 8.4e-13 48.2 0.1 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SH3_9 PF14604.6 EDO18041.1 - 7.2e-10 38.6 0.1 1.4e-09 37.7 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SAM_1 PF00536.30 EDO18041.1 - 1.7e-05 25.2 0.1 3.2e-05 24.3 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PH_11 PF15413.6 EDO18041.1 - 9.6e-05 22.8 0.1 0.0012 19.2 0.0 3.1 2 1 0 2 2 2 1 Pleckstrin homology domain PH_8 PF15409.6 EDO18041.1 - 0.00046 20.4 0.0 0.042 14.1 0.0 2.8 2 0 0 2 2 2 1 Pleckstrin homology domain SH3_2 PF07653.17 EDO18041.1 - 0.0023 17.5 0.0 0.0046 16.6 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain BORCS8 PF10167.9 EDO18041.1 - 0.62 10.0 6.1 2.1 8.3 0.5 3.3 3 0 0 3 3 3 0 BLOC-1-related complex sub-unit 8 EMP70 PF02990.16 EDO18042.1 - 3.2e-101 339.6 20.8 4.2e-101 339.2 20.8 1.1 1 0 0 1 1 1 1 Endomembrane protein 70 LSM PF01423.22 EDO18043.1 - 7.5e-16 57.6 0.1 1.2e-15 57.0 0.1 1.3 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EDO18043.1 - 1.6e-06 28.1 0.0 3.7e-06 27.0 0.0 1.6 1 0 0 1 1 1 1 Ataxin 2 SM domain Hfq PF17209.3 EDO18043.1 - 0.21 11.2 0.7 0.32 10.7 0.0 1.6 2 0 0 2 2 2 0 Hfq protein Ank_4 PF13637.6 EDO18044.1 - 1.1e-06 29.0 4.6 0.0013 19.2 0.6 3.0 2 1 0 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 EDO18044.1 - 3.3e-06 27.6 4.4 0.026 15.1 1.1 2.9 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) KilA-N PF04383.13 EDO18044.1 - 2.7e-05 24.0 0.6 2.7e-05 24.0 0.6 4.5 3 2 0 3 3 3 1 KilA-N domain Ank_5 PF13857.6 EDO18044.1 - 0.00019 21.7 0.3 0.00019 21.7 0.3 3.5 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Ank PF00023.30 EDO18044.1 - 0.0069 16.8 3.2 1.7 9.3 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeat SOAR PF16533.5 EDO18044.1 - 0.018 15.0 11.0 2.1 8.4 6.1 3.1 2 0 0 2 2 2 0 STIM1 Orai1-activating region Ank_3 PF13606.6 EDO18044.1 - 0.033 14.7 3.4 11 7.0 0.2 3.4 3 0 0 3 3 3 0 Ankyrin repeat SelP_N PF04592.14 EDO18044.1 - 0.93 8.8 15.0 2.8 7.3 15.0 1.7 1 0 0 1 1 1 0 Selenoprotein P, N terminal region ALG3 PF05208.13 EDO18045.1 - 8.4e-127 423.5 26.2 1e-126 423.2 26.2 1.0 1 0 0 1 1 1 1 ALG3 protein LisH PF08513.11 EDO18046.1 - 1.1e-05 25.2 0.2 2e-05 24.4 0.2 1.4 1 0 0 1 1 1 1 LisH WD40 PF00400.32 EDO18047.1 - 3.3e-20 72.0 12.1 2.2e-05 25.1 0.6 4.7 4 0 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDO18047.1 - 1.1e-07 32.1 0.0 0.099 13.0 0.0 4.4 2 2 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EDO18047.1 - 0.00068 19.1 0.0 0.001 18.5 0.0 1.3 1 0 0 1 1 1 1 WD40-like domain Nup160 PF11715.8 EDO18047.1 - 0.00083 18.1 2.6 0.2 10.3 0.2 2.8 3 0 0 3 3 3 2 Nucleoporin Nup120/160 eIF2A PF08662.11 EDO18047.1 - 0.011 15.7 0.0 8.6 6.2 0.0 3.4 2 1 1 3 3 3 0 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 EDO18047.1 - 0.045 12.7 0.3 0.26 10.2 0.0 2.3 2 2 2 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein GatB_N PF02934.15 EDO18048.1 - 1.7e-92 309.7 0.0 2.2e-92 309.3 0.0 1.1 1 0 0 1 1 1 1 GatB/GatE catalytic domain GatB_Yqey PF02637.18 EDO18048.1 - 1.8e-28 99.3 0.8 2.9e-28 98.6 0.8 1.3 1 0 0 1 1 1 1 GatB domain SpoVIF PF14069.6 EDO18048.1 - 0.24 11.2 1.8 1.7 8.5 0.0 2.8 3 0 0 3 3 3 0 Stage VI sporulation protein F Nucleoporin_N PF08801.11 EDO18049.1 - 4.2e-140 467.3 18.5 8.8e-140 466.3 15.4 2.2 2 0 0 2 2 2 1 Nup133 N terminal like Nucleoporin_C PF03177.14 EDO18049.1 - 4.8e-129 431.8 4.3 3.6e-128 428.9 4.3 2.0 1 1 0 1 1 1 1 Non-repetitive/WGA-negative nucleoporin C-terminal Med2 PF11214.8 EDO18049.1 - 0.64 10.2 3.5 6 7.1 0.0 3.6 3 0 0 3 3 3 0 Mediator complex subunit 2 HSP70 PF00012.20 EDO18050.1 - 2.8e-258 858.1 7.8 3.1e-258 857.9 7.8 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EDO18050.1 - 1e-16 60.7 0.1 1.3e-15 57.1 0.0 2.0 2 0 0 2 2 2 1 MreB/Mbl protein FGGY_C PF02782.16 EDO18050.1 - 0.00086 19.1 0.0 0.0017 18.1 0.0 1.5 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain DDR PF08841.10 EDO18050.1 - 0.012 14.6 0.5 0.29 10.1 0.2 2.2 2 0 0 2 2 2 0 Diol dehydratase reactivase ATPase-like domain Hydantoinase_A PF01968.18 EDO18050.1 - 0.039 13.2 1.7 0.15 11.3 0.1 2.6 2 1 0 2 2 2 0 Hydantoinase/oxoprolinase Golgin_A5 PF09787.9 EDO18050.1 - 0.12 11.8 3.4 0.22 11.0 1.2 2.0 2 0 0 2 2 2 0 Golgin subfamily A member 5 RRN3 PF05327.11 EDO18050.1 - 0.7 8.4 3.3 1.1 7.7 3.3 1.3 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Ribosomal_S8e PF01201.22 EDO18051.1 - 6.4e-56 188.3 3.2 7.6e-56 188.1 3.2 1.1 1 0 0 1 1 1 1 Ribosomal protein S8e zf-CSL PF05207.13 EDO18052.1 - 6.8e-22 77.0 0.6 8.8e-22 76.6 0.6 1.2 1 0 0 1 1 1 1 CSL zinc finger Zn-ribbon_8 PF09723.10 EDO18052.1 - 0.0048 17.0 0.3 0.0082 16.2 0.3 1.4 1 0 0 1 1 1 1 Zinc ribbon domain ATPase-cat_bd PF12156.8 EDO18052.1 - 0.11 13.2 0.0 0.15 12.8 0.0 1.3 1 0 0 1 1 1 0 Putative metal-binding domain of cation transport ATPase Prok-RING_1 PF14446.6 EDO18052.1 - 0.41 10.6 3.1 0.83 9.6 3.1 1.5 1 1 0 1 1 1 0 Prokaryotic RING finger family 1 UQ_con PF00179.26 EDO18053.1 - 8.8e-21 74.0 0.2 1.4e-20 73.4 0.2 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RXT2_N PF08595.11 EDO18053.1 - 0.0039 17.2 2.3 0.0059 16.6 2.3 1.3 1 0 0 1 1 1 1 RXT2-like, N-terminal Prok-E2_B PF14461.6 EDO18053.1 - 0.066 12.9 0.0 0.18 11.5 0.0 1.7 1 1 1 2 2 2 0 Prokaryotic E2 family B RWD PF05773.22 EDO18053.1 - 0.087 13.1 0.2 0.087 13.1 0.2 2.1 1 1 1 2 2 2 0 RWD domain Pribosyltran_N PF13793.6 EDO18054.1 - 3e-44 149.7 0.4 5.5e-42 142.4 0.1 2.3 2 0 0 2 2 2 2 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.6 EDO18054.1 - 1.5e-35 122.9 1.7 1e-29 103.8 0.4 2.4 1 1 1 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.27 EDO18054.1 - 7.2e-17 61.4 1.0 1.9e-16 60.0 0.6 1.9 2 0 0 2 2 2 1 Phosphoribosyl transferase domain UPRTase PF14681.6 EDO18054.1 - 0.0019 17.7 0.2 0.0038 16.7 0.1 1.6 2 0 0 2 2 2 1 Uracil phosphoribosyltransferase DUF2007 PF09413.10 EDO18054.1 - 0.067 13.4 0.0 0.14 12.3 0.0 1.5 1 0 0 1 1 1 0 Putative prokaryotic signal transducing protein UCH PF00443.29 EDO18055.1 - 5.3e-63 212.9 0.0 1.9e-62 211.1 0.0 1.8 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EDO18055.1 - 3.9e-23 82.5 2.6 1.2e-17 64.5 0.2 2.3 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase Adap_comp_sub PF00928.21 EDO18057.1 - 3.2e-78 262.7 1.2 4.6e-78 262.2 1.2 1.2 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Pribosyl_synth PF14572.6 EDO18058.1 - 3.3e-41 141.4 0.1 5.5e-41 140.6 0.1 1.4 1 0 0 1 1 1 1 Phosphoribosyl synthetase-associated domain Pribosyltran_N PF13793.6 EDO18058.1 - 1.6e-36 124.8 0.0 1.8e-35 121.4 0.0 2.3 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyltran PF00156.27 EDO18058.1 - 2.2e-12 46.8 1.4 1.6e-11 44.0 1.4 2.1 1 1 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 EDO18058.1 - 0.016 14.6 0.1 0.029 13.8 0.1 1.3 1 0 0 1 1 1 0 Uracil phosphoribosyltransferase PNP_UDP_1 PF01048.20 EDO18058.1 - 0.18 11.1 0.0 0.31 10.3 0.0 1.4 1 0 0 1 1 1 0 Phosphorylase superfamily Pkinase PF00069.25 EDO18059.1 - 3.3e-46 157.8 0.0 6.5e-46 156.8 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO18059.1 - 6.7e-18 64.9 0.0 1.1e-17 64.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase FTA2 PF13095.6 EDO18059.1 - 0.00029 20.6 4.1 0.22 11.1 0.0 3.4 2 1 1 3 3 3 2 Kinetochore Sim4 complex subunit FTA2 NicO PF03824.16 EDO18059.1 - 2.4 7.4 8.9 3.7 6.8 8.9 1.2 1 0 0 1 1 1 0 High-affinity nickel-transport protein DUF3450 PF11932.8 EDO18059.1 - 9.6 5.4 11.3 14 4.8 11.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) DUF21 PF01595.20 EDO18060.1 - 8.4e-35 120.0 0.7 6.5e-34 117.2 0.5 2.0 2 0 0 2 2 2 1 Cyclin M transmembrane N-terminal domain CBS PF00571.28 EDO18060.1 - 0.0012 19.2 0.0 2 8.9 0.0 2.7 2 0 0 2 2 2 2 CBS domain NAD_Gly3P_dh_N PF01210.23 EDO18061.1 - 8.1e-51 172.1 0.0 1.4e-50 171.3 0.0 1.3 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_Gly3P_dh_C PF07479.14 EDO18061.1 - 1.2e-40 139.1 0.9 4.1e-40 137.3 0.3 2.0 2 0 0 2 2 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus F420_oxidored PF03807.17 EDO18061.1 - 0.0071 16.9 0.0 2.2 8.9 0.0 2.7 2 0 0 2 2 2 2 NADP oxidoreductase coenzyme F420-dependent PDH PF02153.17 EDO18061.1 - 0.043 12.8 0.0 7.4 5.5 0.0 2.2 2 0 0 2 2 2 0 Prephenate dehydrogenase Peptidase_M49 PF03571.15 EDO18062.1 - 2.1e-232 772.4 0.1 3.5e-232 771.7 0.1 1.3 1 0 0 1 1 1 1 Peptidase family M49 His_Phos_1 PF00300.22 EDO18063.1 - 6.6e-33 114.0 0.0 2.2e-14 53.6 0.0 3.1 1 1 2 3 3 3 3 Histidine phosphatase superfamily (branch 1) Tma16 PF11176.8 EDO18063.1 - 0.015 15.2 0.0 0.026 14.4 0.0 1.4 1 0 0 1 1 1 0 Translation machinery-associated protein 16 Phos_pyr_kin PF08543.12 EDO18064.1 - 1.5e-80 270.1 1.3 2.3e-80 269.5 1.3 1.2 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase TENA_THI-4 PF03070.16 EDO18064.1 - 2e-54 184.6 0.5 2.8e-54 184.1 0.5 1.2 1 0 0 1 1 1 1 TENA/THI-4/PQQC family PfkB PF00294.24 EDO18064.1 - 6.6e-06 25.6 0.0 1.1e-05 24.9 0.0 1.3 1 0 0 1 1 1 1 pfkB family carbohydrate kinase HK PF02110.15 EDO18064.1 - 0.029 13.8 0.6 0.27 10.6 0.6 2.1 1 1 0 1 1 1 0 Hydroxyethylthiazole kinase family Oxysterol_BP PF01237.18 EDO18065.1 - 1.3e-134 448.8 0.9 2.5e-134 447.8 0.9 1.5 1 0 0 1 1 1 1 Oxysterol-binding protein Ank_5 PF13857.6 EDO18065.1 - 1.2e-15 57.4 0.6 1.7e-06 28.2 0.0 3.4 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 EDO18065.1 - 1.1e-11 45.1 0.1 1.3e-07 32.1 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) PH PF00169.29 EDO18065.1 - 5.7e-10 39.7 0.6 5.7e-10 39.7 0.6 2.5 2 0 0 2 2 2 1 PH domain Ank_3 PF13606.6 EDO18065.1 - 9.9e-10 37.8 0.0 0.0078 16.6 0.0 4.0 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.6 EDO18065.1 - 1.4e-09 38.3 0.1 0.0012 19.4 0.1 3.1 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 EDO18065.1 - 9.3e-09 35.3 0.3 0.00055 20.3 0.1 3.7 3 0 0 3 3 3 2 Ankyrin repeat PH_8 PF15409.6 EDO18065.1 - 5.9e-08 32.9 1.2 2e-07 31.2 1.2 2.0 1 0 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.6 EDO18065.1 - 7.4 7.1 15.4 0.074 13.5 4.8 3.3 3 1 0 3 3 3 0 Pleckstrin homology domain Carn_acyltransf PF00755.20 EDO18066.1 - 1.4e-198 661.3 2.0 1.6e-198 661.1 2.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase zf-rbx1 PF12678.7 EDO18066.1 - 0.78 10.1 5.1 0.4 11.0 2.4 1.9 2 0 0 2 2 2 0 RING-H2 zinc finger domain Rad21_Rec8_N PF04825.13 EDO18067.1 - 2.8e-24 85.4 0.1 6.7e-24 84.2 0.1 1.7 1 0 0 1 1 1 1 N terminus of Rad21 / Rec8 like protein Rad21_Rec8 PF04824.16 EDO18067.1 - 1.2e-10 40.5 0.0 3e-10 39.2 0.0 1.7 1 0 0 1 1 1 1 Conserved region of Rad21 / Rec8 like protein DUF3209 PF11483.8 EDO18067.1 - 1.1 9.7 4.4 1.2 9.6 2.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3209) MIEAP PF16026.5 EDO18068.1 - 0.038 14.2 0.8 4.5 7.4 0.1 2.3 2 0 0 2 2 2 0 Mitochondria-eating protein HMG_box PF00505.19 EDO18070.1 - 2.3e-16 60.0 5.4 3.4e-16 59.4 1.5 2.7 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EDO18070.1 - 3.6e-14 53.1 2.6 6.1e-14 52.4 1.5 2.1 1 1 0 1 1 1 1 HMG-box domain FTCD_C PF04961.12 EDO18070.1 - 0.14 11.9 2.7 0.34 10.7 2.7 1.7 1 0 0 1 1 1 0 Formiminotransferase-cyclodeaminase Hid1 PF12722.7 EDO18070.1 - 9.6 4.2 18.4 12 3.9 18.4 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF155 PF02582.14 EDO18071.1 - 1.7e-57 194.3 1.6 2.5e-57 193.8 1.6 1.2 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 UPF0449 PF15136.6 EDO18071.1 - 0.021 15.3 0.0 0.058 13.9 0.0 1.8 1 0 0 1 1 1 0 Uncharacterised protein family UPF0449 Thiamine_BP PF01910.17 EDO18072.1 - 3.7e-23 81.3 0.0 4e-23 81.1 0.0 1.0 1 0 0 1 1 1 1 Thiamine-binding protein SGS PF05002.15 EDO18072.1 - 0.19 11.9 0.0 0.26 11.4 0.0 1.2 1 0 0 1 1 1 0 SGS domain Trehalase PF01204.18 EDO18073.1 - 6.3e-191 635.7 0.1 8e-191 635.3 0.1 1.1 1 0 0 1 1 1 1 Trehalase Trehalase_Ca-bi PF07492.11 EDO18073.1 - 1.1e-15 57.0 0.4 2.1e-15 56.1 0.4 1.5 1 0 0 1 1 1 1 Neutral trehalase Ca2+ binding domain Ran_BP1 PF00638.18 EDO18074.1 - 3.1e-55 185.7 1.0 4.4e-55 185.2 1.0 1.2 1 0 0 1 1 1 1 RanBP1 domain WH1 PF00568.23 EDO18074.1 - 2.1e-05 24.4 0.5 0.00021 21.2 0.5 2.1 1 1 0 1 1 1 1 WH1 domain VID27_PH PF17747.1 EDO18074.1 - 0.079 13.2 0.0 0.23 11.8 0.0 1.8 1 1 0 1 1 1 0 VID27 PH-like domain Mannosyl_trans2 PF04188.13 EDO18075.1 - 2e-96 324.0 45.6 2.2e-72 244.8 34.2 2.0 1 1 1 2 2 2 2 Mannosyltransferase (PIG-V) RCR PF12273.8 EDO18076.1 - 6.8e-30 104.2 0.7 1.5e-29 103.1 0.6 1.7 1 1 0 1 1 1 1 Chitin synthesis regulation, resistance to Congo red Comm PF15957.5 EDO18076.1 - 0.13 12.6 0.2 0.73 10.2 0.0 2.0 2 0 0 2 2 2 0 Commissureless DUF4834 PF16118.5 EDO18076.1 - 0.35 11.9 2.2 34 5.5 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Aldedh PF00171.22 EDO18077.1 - 1.1e-156 522.0 0.0 1.2e-156 521.9 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.11 EDO18077.1 - 0.14 11.5 0.0 0.24 10.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1487) Maf1 PF09174.10 EDO18078.1 - 1.1e-46 159.1 9.8 3.4e-44 151.1 9.8 2.3 1 1 0 1 1 1 1 Maf1 regulator Tcp11 PF05794.13 EDO18079.1 - 1.6e-113 380.2 1.2 1.9e-113 379.9 1.2 1.1 1 0 0 1 1 1 1 T-complex protein 11 PHAT PF09246.10 EDO18079.1 - 0.13 12.1 0.0 0.33 10.8 0.0 1.7 1 0 0 1 1 1 0 PHAT PRAI PF00697.22 EDO18080.1 - 9.2e-60 201.8 0.0 1.2e-59 201.4 0.0 1.2 1 0 0 1 1 1 1 N-(5'phosphoribosyl)anthranilate (PRA) isomerase zf-ANAPC11 PF12861.7 EDO18081.1 - 1.9e-42 143.2 6.8 2.9e-42 142.6 6.8 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.7 EDO18081.1 - 1.7e-21 76.3 10.4 1.7e-21 76.3 10.4 1.9 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 EDO18081.1 - 8.8e-07 29.2 17.1 1.3e-05 25.5 17.1 2.7 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EDO18081.1 - 0.0003 20.6 4.1 0.0003 20.6 4.1 2.5 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 EDO18081.1 - 0.0023 17.5 4.9 0.0023 17.5 4.9 1.9 2 1 0 2 2 2 1 Zinc-ribbon, C4HC2 type zf-C3HC4 PF00097.25 EDO18081.1 - 0.0026 17.6 12.5 0.013 15.4 12.5 2.2 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EDO18081.1 - 0.0076 16.3 10.5 0.037 14.0 6.9 2.5 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_5 PF14634.6 EDO18081.1 - 0.013 15.5 13.2 0.19 11.7 14.0 2.6 1 1 1 2 2 2 0 zinc-RING finger domain zf-RING_4 PF14570.6 EDO18081.1 - 0.018 14.8 1.2 0.018 14.8 1.2 3.1 2 1 0 2 2 2 0 RING/Ubox like zinc-binding domain FANCL_C PF11793.8 EDO18081.1 - 0.023 14.8 13.4 0.18 12.0 13.4 2.6 1 1 0 1 1 1 0 FANCL C-terminal domain DUF919 PF06034.11 EDO18081.1 - 0.025 14.4 0.0 0.04 13.8 0.0 1.3 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF919) zf-C3HC4_4 PF15227.6 EDO18081.1 - 0.031 14.4 2.7 0.031 14.4 2.7 2.8 2 2 1 3 3 3 0 zinc finger of C3HC4-type, RING zf-RING_11 PF17123.5 EDO18081.1 - 0.16 11.8 10.2 1.8 8.4 10.2 2.4 1 1 0 1 1 1 0 RING-like zinc finger zf-HIT PF04438.16 EDO18081.1 - 0.24 11.3 7.2 0.18 11.7 3.3 2.2 2 0 0 2 2 2 0 HIT zinc finger zf-C3HC4_3 PF13920.6 EDO18081.1 - 0.27 11.1 12.8 4.5 7.2 8.6 2.4 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-HC5HC2H_2 PF13832.6 EDO18081.1 - 0.51 10.5 7.6 0.27 11.4 4.8 1.9 1 1 1 2 2 2 0 PHD-zinc-finger like domain Zn-C2H2_12 PF18112.1 EDO18081.1 - 1.6 9.3 0.0 1.6 9.3 0.0 3.7 3 1 0 3 3 3 0 Autophagy receptor zinc finger-C2H2 domain zf-RING-like PF08746.11 EDO18081.1 - 9.1 6.7 12.8 49 4.3 11.2 2.5 1 1 1 2 2 2 0 RING-like domain Glutaredoxin PF00462.24 EDO18082.1 - 4.1e-11 42.9 0.0 7.7e-11 42.0 0.0 1.5 1 0 0 1 1 1 1 Glutaredoxin GST_N_3 PF13417.6 EDO18082.1 - 0.00026 21.3 0.0 0.00052 20.4 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Thioredoxin_3 PF13192.6 EDO18082.1 - 0.0022 18.0 0.0 0.022 14.8 0.0 2.4 2 0 0 2 2 2 1 Thioredoxin domain DUF836 PF05768.14 EDO18082.1 - 0.0056 17.1 0.1 0.02 15.3 0.0 2.0 2 0 0 2 2 2 1 Glutaredoxin-like domain (DUF836) Thioredoxin_2 PF13098.6 EDO18082.1 - 0.031 14.7 0.0 0.079 13.4 0.0 1.7 1 0 0 1 1 1 0 Thioredoxin-like domain Thioredoxin PF00085.20 EDO18082.1 - 0.032 14.2 0.1 0.08 12.9 0.0 1.8 1 1 0 1 1 1 0 Thioredoxin Thioredoxin_7 PF13899.6 EDO18082.1 - 0.11 12.7 0.1 0.34 11.1 0.0 1.8 1 1 1 2 2 2 0 Thioredoxin-like Thioredoxin_4 PF13462.6 EDO18082.1 - 0.32 11.2 4.1 7.8 6.6 0.0 2.7 2 1 1 3 3 3 0 Thioredoxin Mannosyl_trans3 PF11051.8 EDO18083.1 - 5e-83 278.6 0.0 8.8e-83 277.8 0.0 1.4 1 0 0 1 1 1 1 Mannosyltransferase putative Shufflon_N PF04917.12 EDO18083.1 - 0.027 14.0 0.1 0.041 13.3 0.1 1.2 1 0 0 1 1 1 0 Bacterial shufflon protein, N-terminal constant region Myc_N PF01056.18 EDO18083.1 - 0.029 14.3 0.3 0.047 13.6 0.3 1.2 1 0 0 1 1 1 0 Myc amino-terminal region Opi1 PF08618.10 EDO18083.1 - 0.15 11.3 0.3 0.26 10.5 0.3 1.3 1 0 0 1 1 1 0 Transcription factor Opi1 BNIP2 PF12496.8 EDO18083.1 - 3.9 7.9 9.5 0.94 9.9 4.0 2.5 3 0 0 3 3 3 0 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 Flocculin PF00624.18 EDO18083.1 - 4.7 7.5 8.9 11 6.4 8.9 1.5 1 0 0 1 1 1 0 Flocculin repeat NPR2 PF06218.11 EDO18085.1 - 5.5e-130 434.0 8.5 5.5e-130 434.0 8.5 1.7 2 0 0 2 2 2 1 Nitrogen permease regulator 2 ORC_WH_C PF18137.1 EDO18085.1 - 4.7 7.3 8.5 2 8.5 0.0 3.0 3 0 0 3 3 3 0 Origin recognition complex winged helix C-terminal Kinesin PF00225.23 EDO18086.1 - 5.5e-67 226.1 4.4 7.6e-38 130.3 2.3 4.0 3 1 0 4 4 4 2 Kinesin motor domain Microtub_bd PF16796.5 EDO18086.1 - 8.7e-20 71.2 0.0 8.7e-20 71.2 0.0 3.4 2 1 0 3 3 3 1 Microtubule binding AAA_16 PF13191.6 EDO18086.1 - 0.071 13.5 0.0 2.7 8.4 0.0 2.9 2 0 0 2 2 2 0 AAA ATPase domain Fcf1 PF04900.12 EDO18087.1 - 1.4e-36 124.9 0.9 2.6e-36 124.0 0.9 1.5 1 0 0 1 1 1 1 Fcf1 CDC45 PF02724.14 EDO18087.1 - 0.24 9.7 9.4 0.32 9.2 9.4 1.2 1 0 0 1 1 1 0 CDC45-like protein RR_TM4-6 PF06459.12 EDO18087.1 - 9.3 6.0 13.3 14 5.4 13.3 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Peptidase_S8 PF00082.22 EDO18088.1 - 8.1e-31 107.4 10.1 1.9e-30 106.1 10.0 1.5 1 1 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 EDO18088.1 - 8e-08 32.8 0.0 1.9e-07 31.7 0.0 1.7 1 0 0 1 1 1 1 Peptidase inhibitor I9 Lyase_1 PF00206.20 EDO18089.1 - 6.7e-117 390.3 0.1 9e-117 389.9 0.1 1.2 1 0 0 1 1 1 1 Lyase FumaraseC_C PF10415.9 EDO18089.1 - 5e-25 87.7 0.1 1.4e-24 86.2 0.1 1.8 1 0 0 1 1 1 1 Fumarase C C-terminus Kelch_4 PF13418.6 EDO18090.1 - 5.1e-30 103.2 9.0 1.3e-06 28.3 0.1 6.9 6 2 0 6 6 6 5 Galactose oxidase, central domain Kelch_3 PF13415.6 EDO18090.1 - 2.9e-29 100.8 4.3 9.1e-09 35.4 0.0 6.6 7 0 0 7 7 7 3 Galactose oxidase, central domain DUF4110 PF13422.6 EDO18090.1 - 5.3e-27 93.7 0.0 5.3e-27 93.7 0.0 4.0 4 0 0 4 4 4 1 Domain of unknown function (DUF4110) Kelch_6 PF13964.6 EDO18090.1 - 1.7e-14 53.5 12.1 0.0019 18.4 0.2 6.3 5 1 1 6 6 6 5 Kelch motif Kelch_1 PF01344.25 EDO18090.1 - 6e-11 41.7 7.6 0.021 14.4 0.1 5.4 5 0 0 5 5 5 3 Kelch motif Kelch_5 PF13854.6 EDO18090.1 - 6.3e-11 42.0 4.9 0.13 12.3 0.0 5.8 6 0 0 6 6 6 4 Kelch motif Kelch_2 PF07646.15 EDO18090.1 - 4.8e-05 23.2 12.9 0.19 11.7 0.0 6.0 6 0 0 6 6 6 2 Kelch motif Stealth_CR4 PF17103.5 EDO18090.1 - 0.43 10.5 5.1 0.46 10.4 0.1 3.0 2 0 0 2 2 2 0 Stealth protein CR4, conserved region 4 CAF1C_H4-bd PF12265.8 EDO18091.1 - 1.4e-21 76.5 0.5 5.8e-21 74.5 0.1 2.1 2 0 0 2 2 2 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 EDO18091.1 - 1e-16 61.0 6.6 6.9e-06 26.7 0.0 5.7 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDO18091.1 - 0.0017 18.6 0.1 13 6.2 0.0 3.5 1 1 2 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain DNA_pol_phi PF04931.13 EDO18093.1 - 8.8e-222 738.4 36.4 1.2e-221 738.0 36.4 1.2 1 0 0 1 1 1 1 DNA polymerase phi Dynein_AAA_lid PF17852.1 EDO18093.1 - 0.11 12.6 0.8 3.8 7.6 0.0 3.5 3 0 0 3 3 3 0 Dynein heavy chain AAA lid domain His_Phos_1 PF00300.22 EDO18093.1 - 0.19 11.4 0.4 0.37 10.5 0.4 1.4 1 0 0 1 1 1 0 Histidine phosphatase superfamily (branch 1) BUD22 PF09073.10 EDO18093.1 - 8.2 5.6 37.8 20 4.4 37.8 1.6 1 0 0 1 1 1 0 BUD22 DUF3784 PF12650.7 EDO18094.1 - 0.0092 16.2 3.1 0.031 14.4 3.1 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF3784) ATP-synt_Eps PF04627.13 EDO18095.1 - 5.6e-20 71.1 1.1 6.4e-20 70.9 1.1 1.0 1 0 0 1 1 1 1 Mitochondrial ATP synthase epsilon chain ABC_membrane PF00664.23 EDO18096.1 - 9.3e-58 196.0 6.5 1.3e-57 195.5 6.5 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 EDO18096.1 - 2.7e-34 118.6 0.6 1.1e-33 116.7 0.0 2.4 2 0 0 2 2 2 1 ABC transporter SMC_N PF02463.19 EDO18096.1 - 4.9e-05 22.9 0.0 0.0006 19.3 0.0 2.6 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain IstB_IS21 PF01695.17 EDO18096.1 - 0.00062 19.6 0.0 0.031 14.0 0.0 2.9 2 1 1 3 3 3 1 IstB-like ATP binding protein AAA_16 PF13191.6 EDO18096.1 - 0.0022 18.4 1.0 0.015 15.7 0.0 2.8 2 1 0 2 2 2 1 AAA ATPase domain AAA_29 PF13555.6 EDO18096.1 - 0.0035 17.1 0.0 0.012 15.3 0.0 1.9 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA PF00004.29 EDO18096.1 - 0.012 16.0 0.0 0.12 12.8 0.0 2.5 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EDO18096.1 - 0.014 15.7 1.4 0.12 12.6 0.1 2.9 2 1 0 2 2 2 0 AAA domain DUF2073 PF09846.9 EDO18096.1 - 0.016 15.1 0.2 1.3 8.9 0.0 3.4 4 0 0 4 4 4 0 Uncharacterized protein conserved in archaea (DUF2073) RsgA_GTPase PF03193.16 EDO18096.1 - 0.02 14.8 0.2 0.066 13.1 0.0 1.9 2 0 0 2 2 2 0 RsgA GTPase AAA_5 PF07728.14 EDO18096.1 - 0.026 14.5 0.0 0.15 12.0 0.0 2.4 3 0 0 3 3 2 0 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 EDO18096.1 - 0.072 12.6 0.0 0.25 10.8 0.0 1.9 2 0 0 2 2 2 0 P-loop containing dynein motor region NOGCT PF08155.11 EDO18096.1 - 0.075 13.0 0.0 0.23 11.5 0.0 1.8 1 0 0 1 1 1 0 NOGCT (NUC087) domain Sigma54_activat PF00158.26 EDO18096.1 - 0.081 12.6 0.0 0.34 10.6 0.0 2.0 2 0 0 2 2 2 0 Sigma-54 interaction domain Sigma54_activ_2 PF14532.6 EDO18096.1 - 0.09 12.9 1.1 2.1 8.5 0.0 2.9 3 0 0 3 3 3 0 Sigma-54 interaction domain PAPA-1 PF04795.12 EDO18096.1 - 7.2 7.5 9.5 13 6.7 3.0 2.4 2 0 0 2 2 2 0 PAPA-1-like conserved region AAA_23 PF13476.6 EDO18096.1 - 8.3 6.9 13.5 0.57 10.7 0.1 3.2 4 0 0 4 4 4 0 AAA domain CFC PF09443.10 EDO18099.1 - 0.019 14.8 4.3 0.019 14.8 4.3 2.0 1 1 1 2 2 2 0 Cripto_Frl-1_Cryptic (CFC) Synapsin_N PF10581.9 EDO18099.1 - 0.073 13.0 0.3 0.16 11.9 0.3 1.7 1 0 0 1 1 1 0 Synapsin N-terminal Retrotrans_gag PF03732.17 EDO18100.1 - 1.1e-07 32.0 0.0 2.2e-07 31.1 0.0 1.5 1 0 0 1 1 1 1 Retrotransposon gag protein DUF4939 PF16297.5 EDO18100.1 - 1.3e-05 25.0 0.0 3.4e-05 23.7 0.0 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4939) zf-CCHC PF00098.23 EDO18100.1 - 8.8e-05 22.4 2.5 8.8e-05 22.4 2.5 1.8 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC_6 PF15288.6 EDO18100.1 - 0.05 13.4 2.0 0.095 12.6 2.0 1.4 1 0 0 1 1 1 0 Zinc knuckle RVT_1 PF00078.27 EDO18101.1 - 9.6e-38 129.9 0.3 1.7e-37 129.1 0.3 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 EDO18101.1 - 1.3e-27 95.7 0.0 2.7e-27 94.7 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 EDO18101.1 - 1e-25 90.1 0.0 2e-25 89.1 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 EDO18101.1 - 2.9e-16 59.3 0.8 6.2e-16 58.3 0.1 2.0 2 0 0 2 2 2 1 Integrase zinc binding domain rve PF00665.26 EDO18101.1 - 3.4e-13 49.8 0.0 8.8e-13 48.5 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 EDO18101.1 - 0.016 15.4 0.0 0.052 13.8 0.0 2.0 1 0 0 1 1 1 0 H2C2 zinc finger KdpC PF02669.15 EDO18102.1 - 0.17 11.7 0.0 0.21 11.4 0.0 1.2 1 0 0 1 1 1 0 K+-transporting ATPase, c chain RT_RNaseH_2 PF17919.1 EDO18103.1 - 1.8e-21 76.0 0.1 1.3e-20 73.2 0.1 2.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 EDO18103.1 - 3.5e-21 75.5 0.0 2.3e-20 72.8 0.0 2.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 EDO18103.1 - 1.9e-17 63.5 0.2 4.1e-16 59.2 0.2 2.7 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 EDO18103.1 - 2e-12 47.3 0.0 1.2e-11 44.8 0.0 2.4 2 0 0 2 2 2 1 Integrase core domain RVT_3 PF13456.6 EDO18103.1 - 0.0037 17.1 0.0 0.014 15.2 0.0 2.0 1 0 0 1 1 1 1 Reverse transcriptase-like MLVIN_C PF18697.1 EDO18103.1 - 0.036 14.1 0.6 0.17 12.0 0.1 2.5 3 0 0 3 3 3 0 Murine leukemia virus (MLV) integrase (IN) C-terminal domain Asp_protease PF09668.10 EDO18103.1 - 0.061 13.1 0.0 0.14 12.0 0.0 1.6 1 0 0 1 1 1 0 Aspartyl protease DUF4854 PF16146.5 EDO18104.1 - 0.097 13.0 2.2 1.7 9.1 0.2 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4854) PPR PF01535.20 EDO18105.1 - 0.18 12.2 0.6 2.1 8.8 0.0 3.0 4 0 0 4 4 4 0 PPR repeat Pkinase PF00069.25 EDO18106.1 - 1.2e-72 244.5 0.3 2.5e-71 240.1 0.0 2.2 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO18106.1 - 6.7e-51 173.1 0.0 1e-50 172.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EDO18106.1 - 3.7e-06 26.0 1.8 1.1e-05 24.4 0.0 2.5 3 0 0 3 3 3 1 Fungal protein kinase Kinase-like PF14531.6 EDO18106.1 - 0.00021 20.7 0.1 0.0012 18.3 0.0 2.0 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 EDO18106.1 - 0.023 14.6 0.0 14 5.5 0.0 2.8 2 1 1 3 3 3 0 Phosphotransferase enzyme family Kdo PF06293.14 EDO18106.1 - 0.091 12.1 0.0 2.7 7.3 0.0 2.3 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 EDO18106.1 - 0.2 11.2 0.3 4.2 6.9 0.0 2.3 1 1 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 SBE2 PF17076.5 EDO18107.1 - 8.9e-197 656.0 53.5 3.2e-188 627.7 33.4 2.0 1 1 0 2 2 2 2 SBE2, cell-wall formation DUF4240 PF14024.6 EDO18107.1 - 0.0068 16.6 0.0 0.016 15.4 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF4240) TRCF PF03461.15 EDO18107.1 - 0.096 13.1 0.1 0.23 11.8 0.1 1.6 1 0 0 1 1 1 0 TRCF domain DUF960 PF06124.11 EDO18107.1 - 0.56 10.9 9.0 3.1 8.5 0.5 3.3 3 0 0 3 3 3 0 Staphylococcal protein of unknown function (DUF960) PQ-loop PF04193.14 EDO18108.1 - 1.2e-32 111.4 13.0 4.9e-17 61.5 1.7 2.6 2 0 0 2 2 2 2 PQ loop repeat ER_lumen_recept PF00810.18 EDO18108.1 - 0.0043 17.9 0.9 0.0043 17.9 0.9 3.1 1 1 2 3 3 3 1 ER lumen protein retaining receptor MtN3_slv PF03083.16 EDO18108.1 - 0.3 11.2 13.8 0.093 12.8 0.7 3.7 2 2 1 3 3 3 0 Sugar efflux transporter for intercellular exchange Pyr_redox_2 PF07992.14 EDO18109.1 - 8.1e-52 176.3 0.1 9.3e-52 176.1 0.1 1.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EDO18109.1 - 1.6e-18 67.0 0.1 2e-16 60.3 0.0 2.8 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EDO18109.1 - 1.6e-18 67.0 0.2 2.2e-17 63.3 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EDO18109.1 - 0.00042 19.5 5.3 1.3 8.0 0.1 4.4 2 2 1 5 5 5 2 Glucose inhibited division protein A NAD_binding_7 PF13241.6 EDO18109.1 - 0.00086 19.7 0.0 0.059 13.8 0.0 2.4 2 1 0 2 2 2 1 Putative NAD(P)-binding NAD_binding_8 PF13450.6 EDO18109.1 - 0.0013 18.9 0.0 0.27 11.5 0.0 2.4 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 EDO18109.1 - 0.02 13.6 0.1 6.1 5.4 0.0 3.1 3 1 1 4 4 4 0 HI0933-like protein FAD_binding_2 PF00890.24 EDO18109.1 - 0.02 14.0 0.4 3.1 6.8 0.1 2.6 2 1 1 3 3 3 0 FAD binding domain K_oxygenase PF13434.6 EDO18109.1 - 0.027 13.6 0.0 1.2 8.2 0.0 3.0 2 1 1 3 3 3 0 L-lysine 6-monooxygenase (NADPH-requiring) FAD_binding_3 PF01494.19 EDO18109.1 - 0.064 12.5 0.0 5.4 6.2 0.0 2.2 2 0 0 2 2 2 0 FAD binding domain Thi4 PF01946.17 EDO18109.1 - 0.069 12.4 0.1 0.24 10.6 0.0 1.9 2 0 0 2 2 2 0 Thi4 family Glycos_transf_3 PF00591.21 EDO18110.1 - 1.5e-78 263.9 0.0 2.1e-78 263.5 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family, a/b domain Glycos_trans_3N PF02885.17 EDO18110.1 - 4.6e-13 48.8 0.0 8.6e-13 47.9 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family, helical bundle domain Spc110_C PF18520.1 EDO18111.1 - 3.9e-28 96.8 5.1 3.9e-28 96.8 5.1 3.4 3 0 0 3 3 3 1 Spindle pole body component 110 C-terminal domain HMMR_N PF15905.5 EDO18111.1 - 2.4e-05 24.0 27.5 2.4e-05 24.0 27.5 5.5 1 1 4 5 5 5 1 Hyaluronan mediated motility receptor N-terminal ATG16 PF08614.11 EDO18111.1 - 4.5e-05 23.8 10.9 4.5e-05 23.8 10.9 8.0 3 2 2 7 7 7 2 Autophagy protein 16 (ATG16) Atg14 PF10186.9 EDO18111.1 - 0.00024 20.3 12.8 0.00024 20.3 12.8 5.9 1 1 4 6 6 6 1 Vacuolar sorting 38 and autophagy-related subunit 14 Lebercilin PF15619.6 EDO18111.1 - 0.0003 20.5 19.9 0.0003 20.5 19.9 6.4 1 1 4 5 5 5 1 Ciliary protein causing Leber congenital amaurosis disease NPV_P10 PF05531.12 EDO18111.1 - 0.01 16.3 2.3 0.01 16.3 2.3 9.3 3 2 4 7 7 7 0 Nucleopolyhedrovirus P10 protein SAB PF04382.13 EDO18111.1 - 4.8 7.3 11.0 18 5.5 0.5 3.7 2 0 0 2 2 2 0 SAB domain BORCS6 PF10157.9 EDO18112.1 - 0.005 17.1 1.4 0.012 15.9 1.5 1.4 1 1 1 2 2 2 1 BLOC-1-related complex sub-unit 6 UPF0184 PF03670.13 EDO18112.1 - 0.84 10.1 5.3 0.76 10.2 0.1 2.3 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0184) VHS PF00790.19 EDO18113.1 - 3.9e-47 159.7 0.3 2.4e-46 157.1 0.0 2.3 2 1 0 2 2 2 1 VHS domain Alpha_adaptinC2 PF02883.20 EDO18113.1 - 3.8e-22 78.7 1.6 3.8e-22 78.7 1.6 1.8 2 0 0 2 2 2 1 Adaptin C-terminal domain GAT PF03127.14 EDO18113.1 - 1.8e-21 76.2 4.0 7.6e-21 74.2 4.0 2.2 1 0 0 1 1 1 1 GAT domain GGA_N-GAT PF18308.1 EDO18113.1 - 1e-05 25.1 2.8 2.3e-05 23.9 0.3 2.6 2 0 0 2 2 2 1 GGA N-GAT domain Latarcin PF10279.9 EDO18113.1 - 0.06 13.8 4.2 0.17 12.3 4.2 1.8 1 0 0 1 1 1 0 Latarcin precursor NTP_transf_8 PF12281.8 EDO18113.1 - 0.37 10.8 3.0 24 4.8 0.0 3.0 3 0 0 3 3 3 0 Nucleotidyltransferase Fib_alpha PF08702.10 EDO18113.1 - 2.5 8.3 5.4 6.4 7.0 5.4 1.7 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family HSA PF07529.13 EDO18114.1 - 1.8e-13 50.6 0.0 1.8e-13 50.6 0.0 3.6 3 0 0 3 3 3 1 HSA Myb_DNA-bind_6 PF13921.6 EDO18114.1 - 8.2e-09 35.6 0.4 4e-08 33.4 0.4 2.3 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 EDO18114.1 - 0.019 15.1 0.1 0.06 13.6 0.1 1.9 1 0 0 1 1 1 0 Myb-like DNA-binding domain PepSY_TM PF03929.16 EDO18114.1 - 7.5 6.1 8.3 13 5.3 8.3 1.3 1 0 0 1 1 1 0 PepSY-associated TM region BCIP PF13862.6 EDO18115.1 - 8.2e-46 156.4 0.9 1.2e-45 155.8 0.9 1.3 1 0 0 1 1 1 1 p21-C-terminal region-binding protein EMP24_GP25L PF01105.24 EDO18116.1 - 3.9e-33 114.9 1.6 4.7e-33 114.6 1.6 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD ThiF PF00899.21 EDO18117.1 - 1e-60 205.2 0.0 1.4e-60 204.7 0.0 1.1 1 0 0 1 1 1 1 ThiF family Rhodanese PF00581.20 EDO18117.1 - 7.2e-12 45.8 0.1 1.9e-11 44.4 0.1 1.7 2 0 0 2 2 2 1 Rhodanese-like domain Shikimate_DH PF01488.20 EDO18117.1 - 0.021 14.9 0.0 0.045 13.8 0.0 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Mto2_bdg PF12808.7 EDO18117.1 - 0.39 11.0 2.2 0.87 9.9 2.2 1.6 1 0 0 1 1 1 0 Micro-tubular organiser Mto1 C-term Mto2-binding region AT_hook PF02178.19 EDO18118.1 - 0.013 15.3 2.5 0.035 14.0 2.5 1.8 1 0 0 1 1 1 0 AT hook motif Cys_Met_Meta_PP PF01053.20 EDO18119.1 - 4.2e-68 229.6 0.0 1.3e-67 228.0 0.0 1.6 1 1 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 EDO18119.1 - 2.8e-07 29.8 0.0 4.5e-07 29.1 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.21 EDO18119.1 - 0.013 14.7 0.0 0.017 14.3 0.0 1.5 1 1 0 1 1 1 0 Aminotransferase class I and II FBD PF08387.10 EDO18119.1 - 0.091 12.7 0.3 0.45 10.4 0.1 2.2 2 0 0 2 2 2 0 FBD Lectin_leg-like PF03388.13 EDO18120.1 - 1.1e-10 41.2 0.1 4.1e-06 26.3 0.0 2.4 2 0 0 2 2 2 2 Legume-like lectin family PET10 PF17316.2 EDO18122.1 - 2.4e-105 351.6 11.1 3.6e-105 351.0 11.1 1.2 1 0 0 1 1 1 1 Petite colonies protein 10 NAP PF00956.18 EDO18123.1 - 2.6e-86 289.1 12.7 2.6e-86 289.1 12.7 2.3 3 0 0 3 3 3 1 Nucleosome assembly protein (NAP) Secretin_N_2 PF07655.13 EDO18123.1 - 0.15 12.6 3.8 0.4 11.2 3.8 1.6 1 0 0 1 1 1 0 Secretin N-terminal domain PPP4R2 PF09184.11 EDO18123.1 - 0.53 9.8 30.8 1.8 8.0 11.5 2.2 2 0 0 2 2 2 0 PPP4R2 Alb1 PF09135.11 EDO18124.1 - 2e-22 80.1 9.4 2e-22 80.1 9.4 1.4 2 0 0 2 2 2 1 Alb1 RGI1 PF10843.8 EDO18124.1 - 0.04 13.6 0.3 0.066 12.9 0.3 1.4 1 0 0 1 1 1 0 Respiratory growth induced protein 1 ALC PF17527.2 EDO18124.1 - 0.21 11.2 3.5 5.9 6.5 0.9 2.2 2 0 0 2 2 2 0 Phage ALC protein DUF5564 PF17719.1 EDO18124.1 - 3.3 7.9 9.6 0.67 10.1 2.1 2.4 2 1 0 2 2 2 0 Family of unknown function (DUF5564) DUF5427 PF10310.9 EDO18125.1 - 4.1e-116 388.7 32.9 4.8e-116 388.5 32.9 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5427) DDHD PF02862.17 EDO18125.1 - 0.15 12.2 0.1 0.15 12.2 0.1 3.7 1 1 1 2 2 2 0 DDHD domain LSM PF01423.22 EDO18126.1 - 8.9e-15 54.1 0.2 1.4e-14 53.5 0.2 1.3 1 0 0 1 1 1 1 LSM domain PUF PF00806.19 EDO18126.1 - 0.1 12.3 0.1 0.24 11.2 0.1 1.6 1 0 0 1 1 1 0 Pumilio-family RNA binding repeat GCD14 PF08704.10 EDO18127.1 - 1.2e-77 261.0 0.0 1.8e-76 257.1 0.0 2.0 1 1 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit GCD14_N PF14801.6 EDO18127.1 - 2.4e-05 24.1 0.0 7e-05 22.6 0.0 1.9 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit N-term Gcd10p PF04189.13 EDO18127.1 - 0.013 14.6 0.0 0.02 14.0 0.0 1.4 1 0 0 1 1 1 0 Gcd10p family RrnaAD PF00398.20 EDO18127.1 - 0.042 12.9 0.0 0.084 11.9 0.0 1.5 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase DUF3748 PF12566.8 EDO18127.1 - 0.14 12.1 0.0 0.24 11.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3748) Pkinase PF00069.25 EDO18128.1 - 3.2e-60 203.7 0.0 4.5e-60 203.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO18128.1 - 1.8e-36 125.8 0.0 2.6e-36 125.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDO18128.1 - 2.6e-05 23.7 0.0 5.2e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EDO18128.1 - 0.18 10.5 1.8 0.29 9.9 0.0 2.0 2 0 0 2 2 2 0 Fungal protein kinase TrkH PF02386.16 EDO18129.1 - 1e-161 538.8 8.5 1e-161 538.8 8.5 2.5 3 0 0 3 3 3 2 Cation transport protein Snf7 PF03357.21 EDO18130.1 - 7.2e-10 38.7 20.6 7.2e-10 38.7 20.6 1.3 1 1 0 1 1 1 1 Snf7 FAM117 PF15388.6 EDO18130.1 - 0.037 13.5 3.2 0.04 13.4 3.2 1.2 1 0 0 1 1 1 0 Protein Family FAM117 hDGE_amylase PF14701.6 EDO18130.1 - 0.38 9.8 7.0 0.44 9.6 7.0 1.2 1 0 0 1 1 1 0 Glycogen debranching enzyme, glucanotransferase domain CPSase_L_D3 PF02787.19 EDO18130.1 - 1.1 9.6 7.7 1.8 8.9 2.9 2.2 1 1 1 2 2 2 0 Carbamoyl-phosphate synthetase large chain, oligomerisation domain DUF948 PF06103.11 EDO18130.1 - 1.6 9.1 10.2 13 6.1 3.1 3.1 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) LMBR1 PF04791.16 EDO18130.1 - 3.1 6.6 7.8 3.1 6.6 7.8 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein GrpE PF01025.19 EDO18130.1 - 4.7 6.8 15.0 0.6 9.8 10.3 1.8 1 1 1 2 2 2 0 GrpE Fzo_mitofusin PF04799.13 EDO18130.1 - 6.4 6.3 13.9 2.8 7.5 5.4 2.3 1 1 1 2 2 2 0 fzo-like conserved region Cpn60_TCP1 PF00118.24 EDO18131.1 - 2.2e-156 521.3 6.1 2.5e-156 521.1 6.1 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Pyr_redox_2 PF07992.14 EDO18131.1 - 0.018 14.3 0.4 0.12 11.6 0.1 2.0 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Herpes_U59 PF04529.12 EDO18131.1 - 0.13 11.3 0.0 0.2 10.7 0.0 1.2 1 0 0 1 1 1 0 Herpesvirus U59 protein WD40 PF00400.32 EDO18132.1 - 5.8e-27 93.4 16.6 6.9e-06 26.7 1.4 7.2 7 0 0 7 7 7 6 WD domain, G-beta repeat Nup160 PF11715.8 EDO18132.1 - 1.3e-07 30.7 13.2 0.00015 20.5 0.3 5.0 1 1 4 5 5 5 4 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 EDO18132.1 - 0.00018 21.7 3.2 0.072 13.4 0.0 4.6 5 1 2 7 7 7 1 Anaphase-promoting complex subunit 4 WD40 domain Caf4 PF11615.8 EDO18132.1 - 0.00033 20.5 1.3 0.14 12.2 0.0 3.2 3 0 0 3 3 3 2 CCR4-associated factor 4 Mdv1 PF11542.8 EDO18132.1 - 0.0013 18.7 0.4 0.0041 17.0 0.4 1.9 1 0 0 1 1 1 1 Mitochondrial division protein 1 DASH_Spc34 PF08657.10 EDO18133.1 - 1.7e-78 264.0 10.0 1.9e-78 263.8 10.0 1.0 1 0 0 1 1 1 1 DASH complex subunit Spc34 Occludin_ELL PF07303.13 EDO18133.1 - 0.015 16.0 5.0 0.015 16.0 5.0 2.0 2 0 0 2 2 2 0 Occludin homology domain PaaX_C PF08223.11 EDO18133.1 - 0.078 13.3 0.2 0.19 12.0 0.2 1.7 1 0 0 1 1 1 0 PaaX-like protein C-terminal domain VAPB_antitox PF02697.14 EDO18133.1 - 0.11 13.3 8.7 7.4 7.4 0.1 4.1 4 1 0 4 4 4 0 Putative antitoxin Med9 PF07544.13 EDO18133.1 - 0.96 9.6 8.9 0.82 9.8 6.6 2.2 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 Peptidase_M22 PF00814.25 EDO18134.1 - 7.1e-85 285.0 0.0 8.6e-85 284.7 0.0 1.0 1 0 0 1 1 1 1 Glycoprotease family Carbam_trans_N PF02543.15 EDO18134.1 - 0.02 14.6 0.1 0.027 14.1 0.1 1.2 1 0 0 1 1 1 0 Carbamoyltransferase N-terminus HECT PF00632.25 EDO18135.1 - 2.3e-94 316.3 0.0 3.2e-94 315.9 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) WW PF00397.26 EDO18135.1 - 4e-34 116.4 22.8 4.2e-12 45.9 1.3 4.1 4 0 0 4 4 4 3 WW domain C2 PF00168.30 EDO18135.1 - 9.5e-19 67.6 0.0 2.7e-18 66.2 0.0 1.8 1 0 0 1 1 1 1 C2 domain CDC27 PF09507.10 EDO18135.1 - 0.22 10.9 8.8 0.32 10.4 8.8 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 DUF572 PF04502.13 EDO18135.1 - 0.83 9.2 6.5 1.3 8.6 6.5 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF572) Macoilin PF09726.9 EDO18135.1 - 6.3 5.2 11.3 9.4 4.6 11.3 1.2 1 0 0 1 1 1 0 Macoilin family zf-C2H2 PF00096.26 EDO18136.1 - 7.2e-12 45.1 17.9 4e-06 27.0 3.2 3.0 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 EDO18136.1 - 2e-08 34.3 10.5 0.00022 21.4 1.1 2.8 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 EDO18136.1 - 2e-08 34.3 16.7 0.00046 20.8 2.3 3.0 3 0 0 3 3 3 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EDO18136.1 - 3.7e-08 33.4 13.6 4.7e-06 26.8 4.2 3.5 3 0 0 3 3 3 2 Zinc-finger double domain zf-met PF12874.7 EDO18136.1 - 6.5e-06 26.4 8.4 0.012 15.9 0.3 2.8 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-H2C2_5 PF13909.6 EDO18136.1 - 0.0021 17.8 6.9 0.61 9.9 2.1 2.7 2 0 0 2 2 2 2 C2H2-type zinc-finger domain zf-Di19 PF05605.12 EDO18136.1 - 0.0029 17.9 5.4 0.0052 17.1 5.4 1.4 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_6 PF13912.6 EDO18136.1 - 0.028 14.4 2.0 0.028 14.4 2.0 2.4 2 0 0 2 2 2 0 C2H2-type zinc finger PyrI_C PF02748.15 EDO18136.1 - 0.18 11.7 1.1 13 5.8 0.1 2.6 2 0 0 2 2 2 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-BED PF02892.15 EDO18136.1 - 0.32 11.1 11.3 1.4 9.0 5.1 2.7 1 1 1 2 2 2 0 BED zinc finger zf_C2H2_ZHX PF18387.1 EDO18136.1 - 0.45 10.2 5.1 1.5 8.5 3.7 2.3 1 1 1 2 2 2 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-C2HE PF16278.5 EDO18136.1 - 0.53 10.8 10.9 1.7 9.1 2.1 2.7 1 1 1 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2HC_2 PF13913.6 EDO18136.1 - 2.3 8.2 10.3 0.8 9.7 3.2 2.3 2 0 0 2 2 2 0 zinc-finger of a C2HC-type zf-C2H2_2 PF12756.7 EDO18136.1 - 5.8 7.3 12.8 5.8 7.3 2.0 3.2 2 1 1 3 3 3 0 C2H2 type zinc-finger (2 copies) Kelch_6 PF13964.6 EDO18137.1 - 2.7e-13 49.7 0.5 7.6e-08 32.4 0.0 5.1 6 0 0 6 6 6 2 Kelch motif Kelch_4 PF13418.6 EDO18137.1 - 2.7e-10 40.1 2.6 0.00051 20.0 0.0 5.7 6 0 0 6 6 6 3 Galactose oxidase, central domain Kelch_1 PF01344.25 EDO18137.1 - 7.6e-10 38.2 2.7 0.0056 16.2 0.0 4.9 6 0 0 6 6 6 2 Kelch motif Kelch_2 PF07646.15 EDO18137.1 - 2.4e-08 33.6 0.2 0.0016 18.3 0.0 3.7 3 0 0 3 3 3 2 Kelch motif Kelch_5 PF13854.6 EDO18137.1 - 4.6e-05 23.3 0.0 0.0019 18.1 0.0 3.1 3 0 0 3 3 3 1 Kelch motif Kelch_3 PF13415.6 EDO18137.1 - 0.00032 20.9 2.5 3.2 8.2 0.0 6.3 6 1 0 6 6 6 1 Galactose oxidase, central domain Yip1 PF04893.17 EDO18138.1 - 8.9e-11 41.8 9.5 1.2e-10 41.4 9.5 1.3 1 0 0 1 1 1 1 Yip1 domain W2 PF02020.18 EDO18139.1 - 6.6e-15 55.0 6.1 2.1e-14 53.4 6.1 1.9 1 0 0 1 1 1 1 eIF4-gamma/eIF5/eIF2-epsilon NTP_transferase PF00483.23 EDO18139.1 - 8.3e-10 38.6 0.0 2e-09 37.4 0.0 1.6 1 0 0 1 1 1 1 Nucleotidyl transferase Hexapep PF00132.24 EDO18139.1 - 4.8e-09 35.6 23.5 0.00098 18.8 1.2 3.7 1 1 2 3 3 3 3 Bacterial transferase hexapeptide (six repeats) DUF4954 PF16314.5 EDO18139.1 - 4.6e-06 25.1 1.7 4.6e-06 25.1 1.7 2.1 1 1 1 2 2 2 2 Domain of unknown function (DUF4954) Fucokinase PF07959.12 EDO18139.1 - 8.9e-05 21.6 7.8 0.0032 16.5 7.7 2.2 1 1 0 1 1 1 1 L-fucokinase NTP_transf_3 PF12804.7 EDO18139.1 - 0.0024 18.3 0.0 0.0042 17.5 0.0 1.3 1 0 0 1 1 1 1 MobA-like NTP transferase domain Cpn60_TCP1 PF00118.24 EDO18140.1 - 4.9e-153 510.3 15.3 5.6e-153 510.1 15.3 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Fungal_trans_2 PF11951.8 EDO18141.1 - 2.1e-09 36.7 0.1 2.1e-09 36.7 0.1 1.9 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDO18141.1 - 3e-06 27.3 13.9 5e-06 26.5 13.9 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Nop14 PF04147.12 EDO18141.1 - 0.092 11.0 12.2 0.16 10.1 12.2 1.3 1 0 0 1 1 1 0 Nop14-like family DUF5523 PF17661.1 EDO18141.1 - 0.76 9.4 14.5 1.6 8.3 14.5 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5523) CNDH2_C PF16858.5 EDO18141.1 - 1.6 8.5 11.8 3.6 7.4 11.8 1.5 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term CDC45 PF02724.14 EDO18141.1 - 2.6 6.2 15.6 0.015 13.7 6.8 1.7 2 0 0 2 2 2 0 CDC45-like protein DUF2052 PF09747.9 EDO18141.1 - 4.8 7.2 16.5 13 5.9 16.5 1.6 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) DUF1840 PF08895.11 EDO18141.1 - 6.6 7.1 8.2 2.2 8.6 4.9 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1840) Astro_capsid_p PF12226.8 EDO18141.1 - 8.3 5.5 11.5 16 4.5 11.5 1.4 1 0 0 1 1 1 0 Turkey astrovirus capsid protein Svf1_C PF17187.4 EDO18142.1 - 4.1e-42 143.8 4.2 1.4e-41 142.1 4.2 1.8 1 1 0 1 1 1 1 Svf1-like C-terminal lipocalin-like domain Svf1 PF08622.10 EDO18142.1 - 1.5e-38 132.4 0.1 3e-38 131.5 0.0 1.6 2 0 0 2 2 2 1 Svf1-like N-terminal lipocalin domain IMUP PF15761.5 EDO18144.1 - 0.019 15.6 8.0 0.032 14.9 8.0 1.4 1 0 0 1 1 1 0 Immortalisation up-regulated protein DUF4539 PF15072.6 EDO18144.1 - 0.11 12.5 0.0 0.16 12.0 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4539) NPR3 PF03666.13 EDO18144.1 - 0.6 8.8 9.4 0.64 8.8 9.4 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Pap_E4 PF02711.14 EDO18144.1 - 0.74 10.8 3.6 1.4 9.9 3.6 1.5 1 0 0 1 1 1 0 E4 protein SR-25 PF10500.9 EDO18144.1 - 1 8.9 21.5 1.2 8.6 21.4 1.3 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein Zip PF02535.22 EDO18144.1 - 1.4 8.0 4.0 1.4 8.0 4.0 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter DUF3827 PF12877.7 EDO18144.1 - 7.4 4.8 15.7 9.4 4.5 15.7 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF3827) Presenilin PF01080.17 EDO18144.1 - 8.1 5.1 8.3 7.6 5.2 8.3 1.1 1 0 0 1 1 1 0 Presenilin Histone PF00125.24 EDO18145.1 - 9e-20 71.4 2.8 1.2e-19 71.0 2.8 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EDO18145.1 - 1.1e-06 28.9 0.1 2.2e-06 27.9 0.1 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.13 EDO18145.1 - 0.0013 19.2 0.0 0.0023 18.4 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A YscO-like PF16789.5 EDO18145.1 - 0.029 14.4 0.1 0.034 14.2 0.1 1.1 1 0 0 1 1 1 0 YscO-like protein CENP-W PF15510.6 EDO18145.1 - 0.037 14.2 0.0 0.055 13.7 0.0 1.2 1 0 0 1 1 1 0 CENP-W protein Histone_H2A_C PF16211.5 EDO18146.1 - 3.7e-21 74.6 1.1 6.1e-21 73.9 1.1 1.4 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.24 EDO18146.1 - 1.1e-17 64.6 0.0 1.6e-17 64.1 0.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EDO18146.1 - 7.7e-06 26.1 0.0 1.2e-05 25.5 0.0 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone LcrG PF07216.12 EDO18146.1 - 0.043 13.7 0.0 0.065 13.2 0.0 1.4 1 0 0 1 1 1 0 LcrG protein ADK PF00406.22 EDO18147.1 - 4.2e-60 202.2 0.0 4.9e-60 202.0 0.0 1.0 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 EDO18147.1 - 7.4e-24 84.7 0.1 1.4e-23 83.8 0.0 1.5 2 0 0 2 2 2 1 AAA domain ADK_lid PF05191.14 EDO18147.1 - 4.8e-18 64.8 0.1 2e-17 62.9 0.0 2.1 3 0 0 3 3 3 1 Adenylate kinase, active site lid AAA_33 PF13671.6 EDO18147.1 - 1.7e-08 34.7 0.0 6e-08 33.0 0.0 1.7 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 EDO18147.1 - 1.4e-05 25.7 0.0 2.8e-05 24.7 0.0 1.5 2 0 0 2 2 2 1 AAA domain Hydin_ADK PF17213.3 EDO18147.1 - 0.0077 16.5 0.0 0.026 14.8 0.0 1.8 1 1 1 2 2 2 1 Hydin Adenylate kinase-like domain Cytidylate_kin PF02224.18 EDO18147.1 - 0.012 15.3 0.0 0.018 14.8 0.0 1.3 1 0 0 1 1 1 0 Cytidylate kinase AAA PF00004.29 EDO18147.1 - 0.17 12.3 0.1 0.31 11.5 0.1 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) DUF3767 PF12597.8 EDO18148.1 - 8e-39 131.5 0.1 1.2e-38 131.0 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3767) YrhK PF14145.6 EDO18148.1 - 5.2e-05 23.0 0.9 7.9e-05 22.4 0.9 1.2 1 0 0 1 1 1 1 YrhK-like protein Aminotran_1_2 PF00155.21 EDO18149.1 - 3e-73 247.1 0.0 3.7e-73 246.8 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 EDO18149.1 - 2.5e-07 29.6 0.0 4.3e-07 28.8 0.0 1.3 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Preseq_ALAS PF09029.10 EDO18149.1 - 7.4e-05 23.2 0.4 0.00022 21.7 0.4 1.8 1 0 0 1 1 1 1 5-aminolevulinate synthase presequence Aminotran_5 PF00266.19 EDO18149.1 - 0.00035 19.6 0.1 0.0014 17.6 0.1 1.9 2 0 0 2 2 2 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 EDO18149.1 - 0.001 18.4 0.0 0.002 17.5 0.0 1.3 1 1 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.17 EDO18149.1 - 0.056 12.7 0.7 0.3 10.4 0.7 2.0 1 1 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family Aconitase PF00330.20 EDO18150.1 - 4.9e-113 378.6 0.1 4.3e-112 375.5 0.1 2.0 1 1 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 EDO18150.1 - 5.3e-32 110.9 0.0 1.3e-31 109.6 0.0 1.6 1 0 0 1 1 1 1 Aconitase C-terminal domain Porphobil_deam PF01379.20 EDO18151.1 - 4.2e-75 251.7 0.0 5.9e-75 251.3 0.0 1.2 1 0 0 1 1 1 1 Porphobilinogen deaminase, dipyromethane cofactor binding domain Porphobil_deamC PF03900.15 EDO18151.1 - 2.7e-24 85.3 0.9 5.1e-24 84.5 0.9 1.5 1 0 0 1 1 1 1 Porphobilinogen deaminase, C-terminal domain Suf PF05843.14 EDO18152.1 - 0.35 10.8 6.5 0.59 10.1 1.6 2.5 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) Na_Ca_ex PF01699.24 EDO18153.1 - 1.8e-44 151.3 39.9 5.2e-29 101.2 9.4 3.2 3 0 0 3 3 3 2 Sodium/calcium exchanger protein Insulin_TMD PF17870.1 EDO18153.1 - 2.9 8.0 8.6 37 4.5 0.1 4.2 2 1 1 3 3 3 0 Insulin receptor trans-membrane segment Adaptin_N PF01602.20 EDO18154.1 - 5.4e-106 355.2 10.5 5.4e-106 355.2 10.5 1.9 2 0 0 2 2 2 1 Adaptin N terminal region Coatomer_b_Cpla PF14806.6 EDO18154.1 - 2.8e-53 179.3 0.0 7.8e-53 177.8 0.0 1.9 1 0 0 1 1 1 1 Coatomer beta subunit appendage platform Coatamer_beta_C PF07718.12 EDO18154.1 - 4.8e-53 178.8 1.4 4.8e-53 178.8 1.4 2.5 2 0 0 2 2 2 1 Coatomer beta C-terminal region HEAT_2 PF13646.6 EDO18154.1 - 1.2e-06 28.8 4.4 3.1 8.3 0.0 5.7 3 1 3 6 6 6 4 HEAT repeats Cnd1 PF12717.7 EDO18154.1 - 3.8e-06 27.1 14.0 0.00014 21.9 0.8 4.9 3 1 2 5 5 5 1 non-SMC mitotic condensation complex subunit 1 AP4E_app_platf PF14807.6 EDO18154.1 - 0.085 13.2 0.6 1.2 9.5 0.0 3.1 2 1 0 3 3 3 0 Adaptin AP4 complex epsilon appendage platform HEAT PF02985.22 EDO18154.1 - 0.097 13.0 1.5 19 5.9 0.0 4.4 4 0 0 4 4 4 0 HEAT repeat Vac14_Fab1_bd PF12755.7 EDO18154.1 - 0.19 12.3 2.7 0.42 11.2 0.1 2.9 3 0 0 3 3 3 0 Vacuolar 14 Fab1-binding region DUF3361 PF11841.8 EDO18154.1 - 3.3 7.6 10.9 0.43 10.5 1.8 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF3361) HAUS6_N PF14661.6 EDO18154.1 - 7.3 6.1 7.8 1.3 8.5 0.0 3.0 3 0 0 3 3 3 0 HAUS augmin-like complex subunit 6 N-terminus Ribosomal_L7Ae PF01248.26 EDO18155.1 - 3.1e-26 90.9 0.2 5.1e-26 90.3 0.2 1.3 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Torus PF16131.5 EDO18156.1 - 4.3e-34 117.5 2.9 3.2e-33 114.7 0.0 2.4 2 0 0 2 2 2 1 Torus domain RRM_1 PF00076.22 EDO18156.1 - 5e-06 26.2 0.1 1.2e-05 25.0 0.1 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCCH_4 PF18044.1 EDO18156.1 - 0.47 10.3 7.9 0.94 9.4 7.9 1.5 1 0 0 1 1 1 0 CCCH-type zinc finger zf-CCCH_2 PF14608.6 EDO18156.1 - 0.91 10.1 4.6 2.9 8.5 4.6 1.9 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger Neur_chan_memb PF02932.16 EDO18156.1 - 9.3 6.2 6.0 14 5.6 6.0 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region TPR_1 PF00515.28 EDO18157.1 - 3.8e-21 73.9 8.0 5.7e-06 25.9 0.1 5.9 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_2 PF07719.17 EDO18157.1 - 2.9e-20 70.7 6.4 3.6e-05 23.5 0.1 5.9 6 0 0 6 6 5 5 Tetratricopeptide repeat TPR_11 PF13414.6 EDO18157.1 - 2.9e-20 71.7 2.3 3.5e-06 26.6 0.1 5.1 3 1 1 4 4 4 4 TPR repeat TPR_8 PF13181.6 EDO18157.1 - 2.9e-16 58.2 5.2 0.0014 18.7 0.0 5.7 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_14 PF13428.6 EDO18157.1 - 6.3e-15 54.6 1.1 0.0087 16.8 0.0 5.6 3 2 3 6 6 5 4 Tetratricopeptide repeat TPR_17 PF13431.6 EDO18157.1 - 7e-14 51.1 7.6 0.0027 18.0 0.1 5.5 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_16 PF13432.6 EDO18157.1 - 4.3e-13 49.7 0.4 0.00039 21.0 0.1 3.7 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 EDO18157.1 - 1.8e-12 47.6 3.9 0.025 15.1 0.1 4.6 3 1 1 4 4 4 4 Tetratricopeptide repeat TPR_9 PF13371.6 EDO18157.1 - 4.2e-08 33.2 0.0 0.004 17.3 0.0 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_20 PF14561.6 EDO18157.1 - 7.8e-08 32.6 3.2 0.15 12.4 0.0 4.7 3 2 3 6 6 6 3 Tetratricopeptide repeat TPR_6 PF13174.6 EDO18157.1 - 6.3e-07 29.6 0.1 8.1 7.3 0.0 5.6 5 0 0 5 5 5 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EDO18157.1 - 9.8e-05 22.5 3.7 0.012 15.8 1.2 3.3 2 1 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.6 EDO18157.1 - 0.00011 22.5 5.5 0.29 11.4 0.4 4.0 2 1 1 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.6 EDO18157.1 - 0.00011 22.0 0.1 5.2 7.3 0.0 4.2 4 0 0 4 4 4 1 Tetratricopeptide repeat BTAD PF03704.17 EDO18157.1 - 0.0034 17.8 0.1 0.085 13.3 0.0 2.8 2 1 1 3 3 3 1 Bacterial transcriptional activator domain Fis1_TPR_C PF14853.6 EDO18157.1 - 0.032 14.3 1.2 1.1 9.3 0.2 3.0 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat MIT PF04212.18 EDO18157.1 - 0.11 12.5 6.6 3.5 7.8 0.1 4.3 4 0 0 4 4 4 0 MIT (microtubule interacting and transport) domain Glyco_transf_34 PF05637.12 EDO18158.1 - 4.4e-75 252.5 0.0 7.3e-75 251.7 0.0 1.3 1 0 0 1 1 1 1 galactosyl transferase GMA12/MNN10 family Nucleotid_trans PF03407.16 EDO18158.1 - 0.021 14.8 0.0 0.035 14.1 0.0 1.4 1 0 0 1 1 1 0 Nucleotide-diphospho-sugar transferase ARID PF01388.21 EDO18159.1 - 7e-16 58.7 0.1 7e-16 58.7 0.1 4.0 3 1 0 3 3 3 1 ARID/BRIGHT DNA binding domain Pkinase PF00069.25 EDO18160.1 - 4.1e-52 177.2 0.4 3.2e-45 154.5 0.1 2.2 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EDO18160.1 - 9.5e-26 90.6 0.0 7e-23 81.2 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 EDO18160.1 - 5.7e-11 42.3 0.0 5e-10 39.2 0.0 2.0 1 1 0 1 1 1 1 Kinase-like FTA2 PF13095.6 EDO18160.1 - 1.5e-05 24.7 0.2 0.1 12.2 0.1 2.3 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 EDO18160.1 - 0.0012 18.8 0.0 0.0019 18.2 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 EDO18160.1 - 0.058 12.8 0.2 0.096 12.0 0.2 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APS_kinase PF01583.20 EDO18161.1 - 4.8e-07 29.8 0.0 5.6e-07 29.6 0.0 1.1 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_18 PF13238.6 EDO18161.1 - 5.3e-07 30.3 0.3 1.6e-06 28.7 0.1 1.9 2 1 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EDO18161.1 - 5.9e-05 23.3 0.0 7e-05 23.0 0.0 1.1 1 0 0 1 1 1 1 AAA domain SKI PF01202.22 EDO18161.1 - 0.00012 22.2 0.0 0.00017 21.8 0.0 1.3 1 0 0 1 1 1 1 Shikimate kinase Zeta_toxin PF06414.12 EDO18161.1 - 0.0097 15.2 0.0 0.015 14.6 0.0 1.3 1 0 0 1 1 1 1 Zeta toxin AAA_16 PF13191.6 EDO18161.1 - 0.021 15.2 0.0 0.03 14.7 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain CPT PF07931.12 EDO18161.1 - 0.024 14.5 0.0 0.037 13.9 0.0 1.6 1 1 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein AAA PF00004.29 EDO18161.1 - 0.026 15.0 0.1 0.044 14.2 0.1 1.5 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) ABC_tran PF00005.27 EDO18161.1 - 0.047 14.2 0.1 0.053 14.0 0.1 1.3 1 1 0 1 1 1 0 ABC transporter NACHT PF05729.12 EDO18161.1 - 0.061 13.2 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 NACHT domain AAA_30 PF13604.6 EDO18161.1 - 0.1 12.3 0.1 0.16 11.7 0.1 1.2 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.6 EDO18161.1 - 0.14 12.5 0.1 0.23 11.8 0.1 1.3 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 EDO18161.1 - 0.15 11.8 0.1 0.27 10.9 0.1 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain SUV3_C PF12513.8 EDO18162.1 - 2.6e-15 56.0 0.9 7e-15 54.7 0.9 1.8 1 0 0 1 1 1 1 Mitochondrial degradasome RNA helicase subunit C terminal Helicase_C PF00271.31 EDO18162.1 - 4.3e-14 52.8 0.1 1.6e-13 51.0 0.1 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF4904 PF16247.5 EDO18163.1 - 0.015 15.1 0.3 0.029 14.2 0.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4904) F-box-like PF12937.7 EDO18163.1 - 0.14 12.1 0.1 0.3 11.0 0.1 1.6 1 0 0 1 1 1 0 F-box-like zf-C2H2_4 PF13894.6 EDO18165.1 - 2.9e-08 33.9 4.1 0.0016 19.1 0.1 2.4 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.26 EDO18165.1 - 2.7e-07 30.7 6.5 0.0024 18.3 0.1 2.4 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 EDO18165.1 - 0.0033 17.7 1.5 0.72 10.2 0.2 2.4 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 EDO18165.1 - 0.023 14.7 2.9 0.56 10.3 0.1 2.4 2 0 0 2 2 2 0 C2H2-type zinc finger zinc_ribbon_15 PF17032.5 EDO18165.1 - 0.051 14.3 0.8 0.1 13.4 0.8 1.5 1 0 0 1 1 1 0 zinc-ribbon family zf-C2HE PF16278.5 EDO18165.1 - 0.054 13.9 5.0 1.6 9.3 0.8 2.5 1 1 1 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_11 PF16622.5 EDO18165.1 - 0.11 12.3 3.9 0.14 12.0 0.0 2.8 3 0 0 3 3 3 0 zinc-finger C2H2-type C1_1 PF00130.22 EDO18165.1 - 0.14 12.1 1.8 11 6.0 0.1 2.3 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-LYAR PF08790.11 EDO18165.1 - 0.16 11.9 1.5 5.5 7.0 0.2 2.3 2 0 0 2 2 2 0 LYAR-type C2HC zinc finger zf-C2H2_3 PF13878.6 EDO18165.1 - 0.95 9.3 4.5 0.38 10.6 0.6 2.2 1 1 1 2 2 2 0 zinc-finger of acetyl-transferase ESCO Herpes_capsid PF06112.11 EDO18165.1 - 1.5 8.9 7.7 2.5 8.2 7.7 1.3 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein zf-H2C2_2 PF13465.6 EDO18165.1 - 4.7 7.8 8.8 17 6.1 2.0 3.4 3 1 0 3 3 3 0 Zinc-finger double domain tRNA-synt_1 PF00133.22 EDO18167.1 - 1.2e-146 489.5 0.7 1.7e-146 489.0 0.7 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 EDO18167.1 - 2.4e-22 79.2 0.2 1.6e-14 53.5 0.1 3.6 3 0 0 3 3 3 3 tRNA synthetases class I (M) Anticodon_1 PF08264.13 EDO18167.1 - 1.8e-21 76.7 1.6 4e-21 75.5 1.6 1.6 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA SAS4 PF15460.6 EDO18167.1 - 0.025 14.7 0.0 0.11 12.6 0.0 2.1 1 0 0 1 1 1 0 Something about silencing, SAS, complex subunit 4 Epsilon_antitox PF08998.11 EDO18167.1 - 0.045 14.0 0.8 0.98 9.7 0.4 2.8 2 0 0 2 2 2 0 Bacterial epsilon antitoxin tRNA-synt_1_2 PF13603.6 EDO18167.1 - 0.066 12.7 0.0 0.14 11.7 0.0 1.5 1 0 0 1 1 1 0 Leucyl-tRNA synthetase, Domain 2 zf-FPG_IleRS PF06827.14 EDO18167.1 - 6 6.8 6.7 18 5.3 6.7 1.9 1 1 0 1 1 1 0 Zinc finger found in FPG and IleRS Pkinase PF00069.25 EDO18168.1 - 9.6e-59 198.9 0.4 1.1e-57 195.4 0.1 2.1 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO18168.1 - 2.4e-26 92.6 0.3 7.5e-26 91.0 0.2 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EDO18168.1 - 0.0025 16.8 0.1 0.0044 16.0 0.1 1.5 1 0 0 1 1 1 1 Haspin like kinase domain Imm7 PF15585.6 EDO18168.1 - 0.029 14.6 0.1 0.059 13.7 0.1 1.4 1 0 0 1 1 1 0 Immunity protein 7 Kinase-like PF14531.6 EDO18168.1 - 0.077 12.3 0.0 0.13 11.6 0.0 1.3 1 0 0 1 1 1 0 Kinase-like APH PF01636.23 EDO18168.1 - 0.085 12.8 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family CENP-N PF05238.13 EDO18169.1 - 2e-116 389.7 0.1 2.3e-116 389.5 0.1 1.0 1 0 0 1 1 1 1 Kinetochore protein CHL4 like Anp1 PF03452.14 EDO18170.1 - 3.5e-107 357.7 0.0 4.2e-107 357.5 0.0 1.1 1 0 0 1 1 1 1 Anp1 Glycos_transf_2 PF00535.26 EDO18170.1 - 0.0038 17.0 0.0 0.007 16.2 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Alk_phosphatase PF00245.20 EDO18171.1 - 2.2e-119 399.1 0.0 2.6e-119 398.9 0.0 1.0 1 0 0 1 1 1 1 Alkaline phosphatase Metalloenzyme PF01676.18 EDO18171.1 - 0.0052 16.2 0.0 0.0093 15.4 0.0 1.4 1 0 0 1 1 1 1 Metalloenzyme superfamily Vpu PF00558.19 EDO18172.1 - 0.016 14.9 0.3 0.016 14.9 0.3 2.8 2 1 1 3 3 3 0 Vpu protein Med3 PF11593.8 EDO18172.1 - 0.061 12.5 3.7 0.22 10.6 1.1 2.1 2 0 0 2 2 2 0 Mediator complex subunit 3 fungal Sec3_C_2 PF15278.6 EDO18172.1 - 5.8 7.3 10.7 1.2 9.5 0.2 3.7 1 1 2 4 4 4 0 Sec3 exocyst complex subunit Gpr1_Fun34_YaaH PF01184.19 EDO18173.1 - 4.7e-76 255.0 18.4 5.7e-76 254.7 18.4 1.0 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family DUF4179 PF13786.6 EDO18173.1 - 0.0079 16.6 1.0 0.022 15.2 1.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4179) HAD_2 PF13419.6 EDO18174.1 - 5.9e-22 78.6 0.7 5.5e-20 72.2 0.7 2.3 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EDO18174.1 - 1.2e-16 61.6 0.0 2.3e-12 47.6 0.0 2.1 1 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EDO18174.1 - 7.1e-10 38.8 0.0 1.4e-09 37.8 0.0 1.5 2 0 0 2 2 2 1 HAD-hyrolase-like PGP_phosphatase PF09419.10 EDO18174.1 - 4.6e-05 23.1 0.0 0.0093 15.6 0.0 2.3 2 0 0 2 2 2 2 Mitochondrial PGP phosphatase HAD PF12710.7 EDO18174.1 - 0.0071 16.8 0.0 0.029 14.8 0.0 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 EDO18174.1 - 0.037 13.8 0.0 8.7 6.0 0.0 3.0 3 0 0 3 3 3 0 haloacid dehalogenase-like hydrolase S6PP PF05116.13 EDO18174.1 - 0.068 12.7 0.0 0.14 11.6 0.0 1.5 1 0 0 1 1 1 0 Sucrose-6F-phosphate phosphohydrolase GTP_EFTU PF00009.27 EDO18175.1 - 9.1e-67 224.4 0.2 1.3e-66 223.9 0.2 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 EDO18175.1 - 3e-33 114.2 0.0 1.4e-32 112.0 0.0 2.1 2 0 0 2 2 2 1 Elongation factor G, domain IV EFG_C PF00679.24 EDO18175.1 - 7.4e-22 77.2 0.0 2.7e-21 75.4 0.0 2.0 2 0 0 2 2 2 1 Elongation factor G C-terminus EFG_II PF14492.6 EDO18175.1 - 2.3e-13 50.1 0.0 7.4e-13 48.4 0.0 1.9 1 0 0 1 1 1 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.25 EDO18175.1 - 4.4e-12 46.2 0.0 1.5e-11 44.5 0.0 2.0 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EDO18175.1 - 0.00031 20.8 0.2 0.00061 19.8 0.2 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase Sugar_tr PF00083.24 EDO18176.1 - 6.3e-101 338.5 23.3 9.5e-55 186.2 8.3 2.0 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 EDO18176.1 - 1.2e-25 90.2 37.9 2.2e-21 76.2 15.1 2.4 2 1 0 2 2 2 2 Major Facilitator Superfamily Phage_holin_3_2 PF04550.12 EDO18176.1 - 6.4 7.4 11.0 0.42 11.2 2.7 3.0 3 1 1 4 4 4 0 Phage holin family 2 RhoGAP PF00620.27 EDO18177.1 - 1.2e-30 106.4 0.6 1.9e-19 70.0 0.0 2.6 2 0 0 2 2 2 2 RhoGAP domain ThiF PF00899.21 EDO18178.1 - 2.1e-67 227.0 0.0 2.8e-67 226.6 0.0 1.1 1 0 0 1 1 1 1 ThiF family UBA_e1_thiolCys PF10585.9 EDO18178.1 - 4.8e-06 26.7 13.8 0.001 19.1 0.3 2.8 2 1 1 3 3 3 2 Ubiquitin-activating enzyme active site UAE_UbL PF14732.6 EDO18178.1 - 0.0073 16.9 1.3 0.035 14.7 1.3 2.2 1 0 0 1 1 1 1 Ubiquitin/SUMO-activating enzyme ubiquitin-like domain NAD_binding_7 PF13241.6 EDO18178.1 - 0.042 14.3 0.0 0.24 11.9 0.0 2.3 1 0 0 1 1 1 0 Putative NAD(P)-binding Iso_dh PF00180.20 EDO18179.1 - 2e-103 346.2 0.0 2.2e-103 346.1 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase UBA PF00627.31 EDO18180.1 - 1.8e-08 34.1 0.9 3e-08 33.4 0.1 1.8 2 0 0 2 2 2 1 UBA/TS-N domain UBA_4 PF14555.6 EDO18180.1 - 0.00028 20.7 0.0 0.00071 19.3 0.0 1.6 1 0 0 1 1 1 1 UBA-like domain Actin PF00022.19 EDO18181.1 - 8.7e-28 97.1 0.0 4.7e-19 68.3 0.0 3.6 3 1 0 3 3 3 3 Actin Actin_micro PF17003.5 EDO18181.1 - 2e-12 47.0 1.4 2.7e-05 23.5 0.0 2.7 3 0 0 3 3 3 2 Putative actin-like family MreB_Mbl PF06723.13 EDO18181.1 - 1.6e-05 23.9 0.0 0.0008 18.3 0.0 2.3 2 0 0 2 2 2 2 MreB/Mbl protein FtsA PF14450.6 EDO18181.1 - 0.04 14.4 0.5 0.13 12.7 0.1 2.3 2 1 0 2 2 2 0 Cell division protein FtsA TPK_catalytic PF04263.16 EDO18182.1 - 2.9e-30 104.8 0.3 6.8e-30 103.6 0.3 1.6 1 1 0 1 1 1 1 Thiamin pyrophosphokinase, catalytic domain TPK_B1_binding PF04265.14 EDO18182.1 - 3.8e-11 42.5 0.2 8.5e-11 41.4 0.2 1.6 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, vitamin B1 binding domain TFIID-18kDa PF02269.16 EDO18183.1 - 1.7e-36 124.1 0.5 1.1e-35 121.5 0.2 2.3 2 0 0 2 2 2 1 Transcription initiation factor IID, 18kD subunit FAM193_C PF15914.5 EDO18183.1 - 0.53 10.1 6.4 0.15 11.8 2.3 2.2 2 0 0 2 2 2 0 FAM193 family C-terminal KH_8 PF17903.1 EDO18184.1 - 1.9e-06 27.9 0.0 3.7e-06 26.9 0.0 1.4 1 0 0 1 1 1 1 Krr1 KH1 domain KH_1 PF00013.29 EDO18184.1 - 0.066 13.0 0.3 0.14 12.0 0.3 1.5 1 0 0 1 1 1 0 KH domain MDM31_MDM32 PF08118.11 EDO18185.1 - 2.4e-99 333.4 25.9 2.6e-88 297.0 15.1 4.1 2 1 1 3 3 3 3 Yeast mitochondrial distribution and morphology (MDM) proteins G-patch_2 PF12656.7 EDO18186.1 - 1.8e-20 72.8 3.0 2.9e-20 72.1 0.1 2.5 3 0 0 3 3 3 1 G-patch domain She9_MDM33 PF05546.11 EDO18187.1 - 1.2e-79 266.8 14.1 1.2e-79 266.8 14.1 2.1 2 0 0 2 2 2 1 She9 / Mdm33 family PAS_9 PF13426.7 EDO18187.1 - 0.013 15.8 0.6 0.49 10.7 0.1 2.7 1 1 1 2 2 2 0 PAS domain FUSC PF04632.12 EDO18187.1 - 0.99 7.9 3.6 0.24 9.9 0.3 1.6 2 0 0 2 2 2 0 Fusaric acid resistance protein family DUF5320 PF17253.2 EDO18187.1 - 4.5 8.4 9.5 16 6.7 0.0 3.9 4 0 0 4 4 4 0 Family of unknown function (DUF5320) AAA PF00004.29 EDO18188.1 - 3.2e-46 157.0 0.0 9.4e-46 155.5 0.0 1.8 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 EDO18188.1 - 7.4e-09 35.4 0.1 5.8e-08 32.6 0.0 2.4 2 0 0 2 2 2 1 Proteasomal ATPase OB C-terminal domain AAA_2 PF07724.14 EDO18188.1 - 3.6e-08 33.7 0.0 7.5e-08 32.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 EDO18188.1 - 5.5e-08 32.9 0.1 2e-07 31.1 0.1 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EDO18188.1 - 1.1e-07 32.5 0.0 2.1e-05 25.0 0.0 3.2 2 1 0 3 3 3 1 AAA ATPase domain AAA_22 PF13401.6 EDO18188.1 - 1.6e-05 25.2 0.9 0.0024 18.1 0.0 2.8 1 1 1 2 2 2 1 AAA domain AAA_lid_3 PF17862.1 EDO18188.1 - 5.9e-05 22.8 0.2 0.00013 21.7 0.2 1.6 1 0 0 1 1 1 1 AAA+ lid domain DUF815 PF05673.13 EDO18188.1 - 6.5e-05 22.2 0.0 0.00011 21.4 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF815) RuvB_N PF05496.12 EDO18188.1 - 0.00025 20.8 0.0 0.00072 19.3 0.0 1.8 2 0 0 2 2 1 1 Holliday junction DNA helicase RuvB P-loop domain NTPase_1 PF03266.15 EDO18188.1 - 0.0003 20.7 0.2 0.0015 18.5 0.0 2.2 3 0 0 3 3 3 1 NTPase AAA_14 PF13173.6 EDO18188.1 - 0.0011 19.0 0.0 0.0035 17.4 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 EDO18188.1 - 0.0014 19.2 0.0 0.0062 17.1 0.0 2.1 2 0 0 2 2 2 1 AAA domain TsaE PF02367.17 EDO18188.1 - 0.0014 18.6 0.0 0.0026 17.8 0.0 1.4 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_30 PF13604.6 EDO18188.1 - 0.0018 18.0 0.0 0.0045 16.7 0.0 1.8 1 1 0 1 1 1 1 AAA domain TIP49 PF06068.13 EDO18188.1 - 0.0023 17.2 0.0 0.0054 16.0 0.0 1.5 1 1 0 1 1 1 1 TIP49 P-loop domain AAA_7 PF12775.7 EDO18188.1 - 0.0024 17.4 0.0 0.021 14.3 0.0 2.1 2 0 0 2 2 2 1 P-loop containing dynein motor region RNA_helicase PF00910.22 EDO18188.1 - 0.0025 18.2 0.0 0.0049 17.2 0.0 1.5 1 0 0 1 1 1 1 RNA helicase AAA_3 PF07726.11 EDO18188.1 - 0.0026 17.6 0.0 0.0075 16.1 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) TniB PF05621.11 EDO18188.1 - 0.0049 16.3 0.0 0.37 10.2 0.0 2.5 2 0 0 2 2 2 1 Bacterial TniB protein AAA_33 PF13671.6 EDO18188.1 - 0.0062 16.7 0.0 0.014 15.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 EDO18188.1 - 0.0066 15.8 0.0 0.018 14.4 0.0 1.7 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.26 EDO18188.1 - 0.0081 15.9 0.0 0.16 11.6 0.0 2.4 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_24 PF13479.6 EDO18188.1 - 0.0086 15.8 0.0 0.016 14.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.6 EDO18188.1 - 0.013 15.7 0.0 0.031 14.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 EDO18188.1 - 0.014 15.3 0.1 0.11 12.4 0.0 2.2 1 1 0 2 2 2 0 NACHT domain ATPase_2 PF01637.18 EDO18188.1 - 0.021 14.7 0.1 0.32 10.9 0.0 2.4 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea AAA_11 PF13086.6 EDO18188.1 - 0.029 14.1 0.1 0.069 12.9 0.0 1.7 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 EDO18188.1 - 0.032 13.9 0.0 0.082 12.6 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein ABC_tran PF00005.27 EDO18188.1 - 0.1 13.1 0.3 0.43 11.1 0.0 2.3 2 1 0 2 2 2 0 ABC transporter Zeta_toxin PF06414.12 EDO18188.1 - 0.11 11.8 0.0 0.21 10.8 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_25 PF13481.6 EDO18188.1 - 0.11 12.0 1.0 0.47 10.0 0.1 2.2 2 1 0 3 3 3 0 AAA domain AAA_19 PF13245.6 EDO18188.1 - 0.13 12.6 0.1 0.38 11.1 0.0 1.8 2 0 0 2 2 1 0 AAA domain DnaB_C PF03796.15 EDO18188.1 - 0.51 9.6 2.6 3.6 6.8 0.2 2.7 2 1 1 3 3 3 0 DnaB-like helicase C terminal domain DUF1640 PF07798.11 EDO18189.1 - 5.3e-24 85.2 4.6 7.5e-24 84.7 4.6 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1640) PAS_12 PF18095.1 EDO18189.1 - 0.0093 15.6 0.4 0.017 14.7 0.4 1.5 1 0 0 1 1 1 1 UPF0242 C-terminal PAS-like domain MSC PF09402.10 EDO18189.1 - 1 8.8 3.8 1.4 8.3 3.8 1.1 1 0 0 1 1 1 0 Man1-Src1p-C-terminal domain ECH_1 PF00378.20 EDO18190.1 - 7.3e-18 64.8 0.0 9.3e-18 64.4 0.0 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EDO18190.1 - 9.8e-12 45.0 0.0 1.3e-11 44.7 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Init_tRNA_PT PF04179.12 EDO18190.1 - 0.094 13.0 0.0 0.16 12.3 0.0 1.4 1 0 0 1 1 1 0 Rit1 DUSP-like domain WH1 PF00568.23 EDO18191.1 - 5.6e-33 113.2 0.0 7.6e-33 112.8 0.0 1.2 1 0 0 1 1 1 1 WH1 domain WH2 PF02205.20 EDO18191.1 - 2.5e-05 23.9 1.2 5.4e-05 22.9 1.2 1.6 1 0 0 1 1 1 1 WH2 motif CAP_N PF01213.19 EDO18191.1 - 0.0012 18.4 0.7 0.0012 18.4 0.7 9.5 1 1 3 4 4 4 1 Adenylate cyclase associated (CAP) N terminal GCIP PF13324.6 EDO18192.1 - 5e-39 134.5 7.9 6.6e-39 134.1 7.9 1.1 1 0 0 1 1 1 1 Grap2 and cyclin-D-interacting Goodbye PF17109.5 EDO18192.1 - 0.13 12.7 1.8 0.54 10.7 0.4 2.8 2 1 1 3 3 3 0 fungal STAND N-terminal Goodbye domain STN1_2 PF09170.10 EDO18192.1 - 0.99 9.6 5.0 2.4 8.4 5.0 1.6 1 0 0 1 1 1 0 CST, Suppressor of cdc thirteen homolog, complex subunit STN1 DUF4473 PF14747.6 EDO18192.1 - 0.99 10.0 4.2 11 6.6 0.3 3.7 4 0 0 4 4 4 0 Domain of unknown function (DUF4473) Ribosomal_S30 PF04758.14 EDO18193.1 - 1.2e-29 102.3 6.0 1.3e-29 102.2 6.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S30 Aminotran_5 PF00266.19 EDO18194.1 - 4.8e-41 140.9 0.0 6.4e-41 140.5 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Hus1 PF04005.12 EDO18195.1 - 1.7e-19 70.0 7.4 1.4e-17 63.7 7.4 2.2 1 1 0 1 1 1 1 Hus1-like protein RmlD_sub_bind PF04321.17 EDO18196.1 - 0.00043 19.5 0.0 0.021 13.9 0.0 2.2 2 0 0 2 2 2 2 RmlD substrate binding domain Epimerase PF01370.21 EDO18196.1 - 0.00051 19.6 0.0 0.0031 17.0 0.0 1.9 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EDO18196.1 - 0.00058 19.0 0.0 0.0068 15.4 0.0 2.1 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 EDO18196.1 - 0.0035 17.3 0.0 0.045 13.6 0.0 2.2 2 0 0 2 2 2 1 NAD(P)H-binding adh_short PF00106.25 EDO18196.1 - 0.017 14.6 0.0 0.28 10.6 0.0 2.5 2 1 0 2 2 2 0 short chain dehydrogenase TPR_1 PF00515.28 EDO18197.1 - 4.2e-07 29.5 0.4 0.00099 18.8 0.0 2.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 EDO18197.1 - 3.7e-05 23.5 0.2 0.032 14.4 0.0 2.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 EDO18197.1 - 0.0068 16.5 1.1 0.48 10.8 0.0 2.8 3 0 0 3 3 3 1 Tetratricopeptide repeat CdiI_3 PF18616.1 EDO18197.1 - 0.029 14.2 1.2 0.056 13.3 1.2 1.5 1 0 0 1 1 1 0 CDI immunity proteins BORCS7 PF16088.5 EDO18197.1 - 0.057 13.7 1.0 0.11 12.8 1.0 1.5 1 0 0 1 1 1 0 BLOC-1-related complex sub-unit 7 Nucleoporin_FG2 PF15967.5 EDO18198.1 - 0.2 10.1 2.2 0.26 9.8 2.2 1.1 1 0 0 1 1 1 0 Nucleoporin FG repeated region DUF641 PF04859.12 EDO18198.1 - 5.8 7.3 9.0 18 5.7 2.9 2.6 1 1 0 2 2 2 0 Plant protein of unknown function (DUF641) zf-C2H2 PF00096.26 EDO18199.1 - 6.8e-06 26.2 14.3 0.0024 18.2 0.7 4.0 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EDO18199.1 - 0.096 13.6 17.0 0.3 12.0 0.7 4.0 3 1 0 3 3 3 0 C2H2-type zinc finger zf-C2H2_2 PF12756.7 EDO18199.1 - 0.12 12.7 0.0 0.12 12.7 0.0 3.6 4 0 0 4 4 4 0 C2H2 type zinc-finger (2 copies) zf-C2H2_aberr PF17017.5 EDO18199.1 - 0.16 12.1 7.6 1.2 9.2 1.2 2.8 1 1 1 2 2 2 0 Aberrant zinc-finger zf-C2H2_11 PF16622.5 EDO18199.1 - 0.48 10.2 5.3 5.9 6.7 0.1 3.1 3 0 0 3 3 3 0 zinc-finger C2H2-type zf-H2C2_2 PF13465.6 EDO18199.1 - 1.7 9.2 17.4 1.6 9.3 0.8 4.5 4 1 0 4 4 4 0 Zinc-finger double domain IlvN PF07991.12 EDO18200.1 - 3.4e-45 153.6 0.0 4.8e-45 153.1 0.0 1.2 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain IlvC PF01450.19 EDO18200.1 - 8e-41 139.7 0.1 3e-40 137.8 0.0 2.0 3 0 0 3 3 3 1 Acetohydroxy acid isomeroreductase, catalytic domain DUF4079 PF13301.6 EDO18202.1 - 0.043 14.0 0.0 0.14 12.3 0.0 1.8 2 1 0 2 2 2 0 Protein of unknown function (DUF4079) MMU163 PF17119.5 EDO18203.1 - 1.6e-07 30.8 0.2 8.8e-07 28.3 0.2 1.9 1 1 0 1 1 1 1 Mitochondrial protein up-regulated during meiosis OS-D PF03392.13 EDO18203.1 - 0.0092 16.0 0.8 0.027 14.5 0.6 2.0 1 1 0 1 1 1 1 Insect pheromone-binding family, A10/OS-D DUF1508 PF07411.12 EDO18203.1 - 0.19 11.6 1.5 4.7 7.1 0.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1508) eIF2A PF08662.11 EDO18204.1 - 1.9e-78 262.8 0.1 5.8e-78 261.2 0.0 1.8 2 0 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A WD40 PF00400.32 EDO18204.1 - 1.4e-05 25.7 1.0 2.3 9.2 0.0 5.0 4 1 1 5 5 5 2 WD domain, G-beta repeat HPS3_N PF14761.6 EDO18204.1 - 0.088 12.3 0.0 0.19 11.3 0.0 1.5 1 0 0 1 1 1 0 Hermansky-Pudlak syndrome 3 EMP70 PF02990.16 EDO18205.1 - 4.7e-191 636.0 14.8 6.6e-191 635.5 14.8 1.2 1 0 0 1 1 1 1 Endomembrane protein 70 Actin PF00022.19 EDO18206.1 - 1.2e-56 192.1 0.0 1e-55 189.1 0.0 1.9 1 1 0 1 1 1 1 Actin Gaa1 PF04114.14 EDO18207.1 - 4e-118 395.6 10.0 5e-118 395.2 10.0 1.1 1 0 0 1 1 1 1 Gaa1-like, GPI transamidase component Aminotran_1_2 PF00155.21 EDO18209.1 - 1.9e-35 122.7 0.0 2.7e-35 122.2 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II DnaJ_C PF01556.18 EDO18210.1 - 2e-29 102.6 0.1 3.6e-29 101.8 0.1 1.4 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 EDO18210.1 - 4.5e-24 84.3 3.8 1.1e-23 83.2 3.8 1.7 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 EDO18210.1 - 5.1e-12 46.0 19.5 2.5e-10 40.5 10.2 1.7 1 1 1 2 2 2 2 DnaJ central domain Anti-TRAP PF15777.5 EDO18210.1 - 6.9 6.7 13.4 9.1 6.3 1.4 3.1 3 1 0 3 3 3 0 Tryptophan RNA-binding attenuator protein inhibitory protein Securin PF04856.13 EDO18211.1 - 1.6e-27 97.0 17.5 2.2e-27 96.6 17.5 1.1 1 0 0 1 1 1 1 Securin sister-chromatid separation inhibitor Ribosomal_L34 PF00468.17 EDO18212.1 - 3.7e-20 71.6 5.0 3.7e-20 71.6 5.0 1.4 1 1 0 1 1 1 1 Ribosomal protein L34 RbcS PF12338.8 EDO18212.1 - 0.0086 16.3 1.4 0.015 15.5 1.4 1.4 1 0 0 1 1 1 1 Ribulose-1,5-bisphosphate carboxylase small subunit Sulfate_transp PF00916.20 EDO18213.1 - 4.9e-124 413.9 14.4 6.1e-124 413.6 14.4 1.1 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 EDO18213.1 - 8e-05 22.3 0.0 0.00018 21.1 0.0 1.5 1 0 0 1 1 1 1 STAS domain STAS_2 PF13466.6 EDO18213.1 - 0.0031 17.8 0.0 0.0059 16.9 0.0 1.4 1 0 0 1 1 1 1 STAS domain MFS_MOT1 PF16983.5 EDO18213.1 - 0.56 10.6 7.3 0.049 14.0 0.8 2.5 2 0 0 2 2 2 0 Molybdate transporter of MFS superfamily MFS_1 PF07690.16 EDO18214.1 - 1.7e-48 165.4 39.7 1.7e-48 165.4 39.7 1.9 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EDO18214.1 - 3.4e-18 65.7 6.5 3.4e-18 65.7 6.5 3.5 4 0 0 4 4 4 1 Sugar (and other) transporter TRI12 PF06609.13 EDO18214.1 - 9.5e-07 27.6 14.6 9.5e-07 27.6 14.6 1.6 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Zip PF02535.22 EDO18214.1 - 0.029 13.6 0.3 0.029 13.6 0.3 2.9 3 1 1 4 4 4 0 ZIP Zinc transporter TRM PF02005.16 EDO18215.1 - 9.6e-144 479.2 0.0 1.2e-143 478.8 0.0 1.0 1 0 0 1 1 1 1 N2,N2-dimethylguanosine tRNA methyltransferase Met_10 PF02475.16 EDO18215.1 - 3.6e-05 23.6 0.6 6.4e-05 22.8 0.1 1.7 2 0 0 2 2 2 1 Met-10+ like-protein FliH PF02108.16 EDO18215.1 - 0.042 13.9 0.0 0.078 13.0 0.0 1.4 1 0 0 1 1 1 0 Flagellar assembly protein FliH PrmA PF06325.13 EDO18215.1 - 0.17 11.3 0.2 0.27 10.6 0.2 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Rubredoxin_2 PF18073.1 EDO18215.1 - 0.27 11.0 3.3 0.55 10.0 3.3 1.5 1 0 0 1 1 1 0 Rubredoxin metal binding domain CBFD_NFYB_HMF PF00808.23 EDO18216.1 - 0.00052 20.3 0.1 0.0011 19.2 0.1 1.7 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CCDC53 PF10152.9 EDO18216.1 - 0.013 16.0 4.5 0.021 15.2 4.5 1.4 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex MPM1 PF17234.2 EDO18216.1 - 0.58 10.4 8.3 0.47 10.7 6.5 1.7 2 0 0 2 2 2 0 Mitochondrial peculiar membrane protein 1 Nyv1_N PF09426.10 EDO18217.1 - 5.8e-59 198.0 0.3 1.1e-58 197.2 0.3 1.4 1 0 0 1 1 1 1 Vacuolar R-SNARE Nyv1 N terminal Synaptobrevin PF00957.21 EDO18217.1 - 9.1e-29 99.1 2.4 1.4e-28 98.5 2.4 1.3 1 0 0 1 1 1 1 Synaptobrevin Retrotrans_gag PF03732.17 EDO18217.1 - 0.12 12.6 0.7 0.27 11.5 0.3 1.7 1 1 0 1 1 1 0 Retrotransposon gag protein F-box-like PF12937.7 EDO18218.1 - 5.3e-05 23.0 0.1 0.0001 22.1 0.1 1.4 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EDO18218.1 - 0.00098 18.9 0.3 0.0023 17.8 0.3 1.5 1 0 0 1 1 1 1 F-box domain TPR_1 PF00515.28 EDO18218.1 - 0.014 15.2 0.1 0.034 14.0 0.1 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat MIT PF04212.18 EDO18218.1 - 0.014 15.4 0.6 0.035 14.2 0.6 1.7 1 0 0 1 1 1 0 MIT (microtubule interacting and transport) domain TPR_7 PF13176.6 EDO18218.1 - 0.11 12.6 0.0 0.29 11.2 0.0 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat Abhydrolase_1 PF00561.20 EDO18219.1 - 2.5e-20 73.2 0.0 2.6e-15 56.8 0.0 2.2 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EDO18219.1 - 2.3e-12 48.0 0.0 3.7e-12 47.3 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EDO18219.1 - 5e-10 39.0 0.0 1.7e-08 34.0 0.0 2.7 2 1 0 2 2 2 1 Serine aminopeptidase, S33 DUF915 PF06028.11 EDO18219.1 - 2.9e-06 26.8 0.1 0.00038 19.9 0.1 2.3 2 0 0 2 2 2 1 Alpha/beta hydrolase of unknown function (DUF915) LIDHydrolase PF10230.9 EDO18219.1 - 4.5e-05 23.1 0.0 0.00017 21.2 0.0 1.8 2 0 0 2 2 2 1 Lipid-droplet associated hydrolase Esterase PF00756.20 EDO18219.1 - 0.0013 18.4 0.0 0.0027 17.4 0.0 1.5 1 0 0 1 1 1 1 Putative esterase DUF676 PF05057.14 EDO18219.1 - 0.0044 16.6 0.0 0.0096 15.5 0.0 1.5 1 0 0 1 1 1 1 Putative serine esterase (DUF676) BAAT_C PF08840.11 EDO18219.1 - 0.0052 16.7 0.0 0.062 13.2 0.0 2.2 2 0 0 2 2 2 1 BAAT / Acyl-CoA thioester hydrolase C terminal Ndr PF03096.14 EDO18219.1 - 0.0062 15.3 0.0 0.015 14.1 0.0 1.5 1 0 0 1 1 1 1 Ndr family Ser_hydrolase PF06821.13 EDO18219.1 - 0.0066 16.3 0.0 0.013 15.3 0.0 1.5 1 0 0 1 1 1 1 Serine hydrolase Abhydrolase_3 PF07859.13 EDO18219.1 - 0.013 15.4 0.0 0.17 11.7 0.0 2.1 2 0 0 2 2 2 0 alpha/beta hydrolase fold Abhydrolase_5 PF12695.7 EDO18219.1 - 0.014 15.2 0.0 0.41 10.4 0.0 2.3 2 0 0 2 2 2 0 Alpha/beta hydrolase family PGAP1 PF07819.13 EDO18219.1 - 0.014 15.2 0.0 0.024 14.4 0.0 1.4 1 0 0 1 1 1 0 PGAP1-like protein Thioesterase PF00975.20 EDO18219.1 - 0.015 15.4 0.0 0.72 9.9 0.0 2.5 3 0 0 3 3 3 0 Thioesterase domain Chlorophyllase2 PF12740.7 EDO18219.1 - 0.048 12.6 0.0 0.09 11.7 0.0 1.4 1 0 0 1 1 1 0 Chlorophyllase enzyme BUD22 PF09073.10 EDO18220.1 - 0.094 12.0 14.3 0.11 11.8 14.3 1.0 1 0 0 1 1 1 0 BUD22 CLN3 PF02487.17 EDO18220.1 - 0.15 11.1 0.4 0.18 10.8 0.4 1.1 1 0 0 1 1 1 0 CLN3 protein Nop14 PF04147.12 EDO18220.1 - 0.52 8.5 23.7 0.59 8.3 23.7 1.0 1 0 0 1 1 1 0 Nop14-like family Zip PF02535.22 EDO18220.1 - 0.57 9.3 1.2 0.61 9.2 1.2 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter NUT PF12881.7 EDO18220.1 - 3.4 6.0 6.2 4 5.7 6.2 1.1 1 0 0 1 1 1 0 NUT protein Tub_N PF16322.5 EDO18220.1 - 6.8 7.0 14.8 9.3 6.6 14.8 1.2 1 0 0 1 1 1 0 Tubby N-terminal CH PF00307.31 EDO18221.1 - 9.1e-82 270.4 0.2 1.8e-20 73.1 0.0 4.2 4 0 0 4 4 4 4 Calponin homology (CH) domain EF-hand_7 PF13499.6 EDO18221.1 - 1.4e-05 25.5 1.6 4.8e-05 23.7 0.2 2.6 3 0 0 3 3 3 1 EF-hand domain pair CAMSAP_CH PF11971.8 EDO18221.1 - 3.3e-05 23.6 0.0 10 6.1 0.0 4.4 4 0 0 4 4 4 2 CAMSAP CH domain CH_2 PF06294.11 EDO18221.1 - 0.0031 17.6 0.0 7.9 6.7 0.0 3.9 4 0 0 4 4 4 1 CH-like domain in sperm protein EF-hand_1 PF00036.32 EDO18221.1 - 0.071 12.7 0.5 4.4 7.1 0.0 3.0 3 0 0 3 3 3 0 EF hand EF-hand_6 PF13405.6 EDO18221.1 - 0.13 12.2 0.2 22 5.3 0.0 3.3 3 0 0 3 3 3 0 EF-hand domain tRNA_int_endo PF01974.17 EDO18222.1 - 3.6e-27 94.3 0.3 9.8e-27 92.9 0.3 1.7 1 0 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain tRNA_int_endo_N PF02778.14 EDO18222.1 - 0.048 13.3 0.1 2 8.1 0.1 2.5 2 0 0 2 2 2 0 tRNA intron endonuclease, N-terminal domain tRNA_int_end_N2 PF12928.7 EDO18222.1 - 0.14 12.4 0.1 0.53 10.5 0.0 2.0 2 0 0 2 2 2 0 tRNA-splicing endonuclease subunit sen54 N-term F-box-like PF12937.7 EDO18223.1 - 0.00036 20.3 0.1 0.00085 19.2 0.1 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EDO18223.1 - 0.0015 18.3 0.0 0.0043 16.9 0.0 1.7 1 0 0 1 1 1 1 F-box domain DUF3760 PF12586.8 EDO18223.1 - 0.016 15.4 1.3 0.059 13.6 1.3 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3760) Flocculin_t3 PF13928.6 EDO18224.1 - 2.4e-13 50.4 22.9 2.4e-13 50.4 22.9 3.2 3 1 0 3 3 3 1 Flocculin type 3 repeat Pkinase PF00069.25 EDO18225.1 - 1.5e-66 224.5 0.0 2.3e-66 223.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO18225.1 - 1.3e-30 106.5 0.0 2.2e-30 105.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EDO18225.1 - 2.3e-06 26.8 0.0 3e-06 26.4 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 EDO18225.1 - 0.00013 21.4 0.1 0.00054 19.4 0.1 1.9 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EDO18225.1 - 0.00058 19.9 0.3 0.0023 17.9 0.0 2.0 2 1 1 3 3 3 1 Phosphotransferase enzyme family FTA2 PF13095.6 EDO18225.1 - 0.033 13.8 0.0 0.056 13.1 0.0 1.4 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Kinase-like PF14531.6 EDO18225.1 - 0.036 13.4 0.0 0.33 10.2 0.0 2.1 2 0 0 2 2 2 0 Kinase-like RIO1 PF01163.22 EDO18225.1 - 0.054 13.1 0.0 0.11 12.1 0.0 1.5 1 0 0 1 1 1 0 RIO1 family DUF3235 PF11574.8 EDO18225.1 - 0.2 12.5 7.0 0.36 11.7 7.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3235) Chorion_3 PF05387.11 EDO18225.1 - 0.68 9.5 3.2 1.1 8.9 3.2 1.2 1 0 0 1 1 1 0 Chorion family 3 Rgp1 PF08737.10 EDO18226.1 - 1.7e-112 376.7 6.6 1.7e-112 376.7 6.6 2.0 2 0 0 2 2 2 1 Rgp1 Arrestin_C PF02752.22 EDO18226.1 - 2.2e-05 24.9 0.6 0.034 14.6 0.2 3.6 3 0 0 3 3 3 1 Arrestin (or S-antigen), C-terminal domain AA_kinase PF00696.28 EDO18226.1 - 0.067 12.8 0.0 0.2 11.2 0.0 1.7 2 0 0 2 2 2 0 Amino acid kinase family TINF2_N PF14973.6 EDO18226.1 - 0.47 10.8 3.3 0.3 11.4 0.2 2.0 2 0 0 2 2 2 0 TERF1-interacting nuclear factor 2 N-terminus Dopey_N PF04118.14 EDO18228.1 - 2.8e-110 368.3 5.6 4.4e-110 367.6 0.6 3.3 2 1 0 2 2 2 1 Dopey, N-terminal GRIP PF01465.20 EDO18228.1 - 0.1 12.5 1.0 0.41 10.6 0.5 2.4 2 0 0 2 2 2 0 GRIP domain Abhydrolase_2 PF02230.16 EDO18229.1 - 1.1e-61 208.4 0.0 1.4e-61 208.1 0.0 1.0 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase FSH1 PF03959.13 EDO18229.1 - 2.5e-07 30.6 0.0 6.1e-07 29.3 0.0 1.7 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Hydrolase_4 PF12146.8 EDO18229.1 - 1.9e-06 27.4 0.0 0.011 15.0 0.0 3.0 2 1 1 3 3 3 2 Serine aminopeptidase, S33 DLH PF01738.18 EDO18229.1 - 0.00053 19.6 0.0 0.001 18.6 0.0 1.4 2 0 0 2 2 2 1 Dienelactone hydrolase family Abhydrolase_6 PF12697.7 EDO18229.1 - 0.0024 18.5 0.0 0.0028 18.3 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EDO18229.1 - 0.0038 16.9 0.7 0.035 13.7 0.7 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_3 PF07859.13 EDO18229.1 - 0.036 13.9 0.0 0.055 13.3 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold Ribosomal_L12_N PF16320.5 EDO18229.1 - 0.37 10.5 0.1 0.37 10.5 0.1 1.6 2 0 0 2 2 2 0 Ribosomal protein L7/L12 dimerisation domain Mod_r PF07200.13 EDO18230.1 - 2.4e-21 76.4 15.2 2.8e-21 76.2 15.2 1.1 1 0 0 1 1 1 1 Modifier of rudimentary (Mod(r)) protein Retrotrans_gag PF03732.17 EDO18230.1 - 0.00028 21.1 6.2 0.11 12.8 0.8 3.3 1 1 2 3 3 3 2 Retrotransposon gag protein Enkurin PF13864.6 EDO18230.1 - 0.015 15.7 8.8 0.79 10.2 1.6 2.6 1 1 1 2 2 2 0 Calmodulin-binding Occludin_ELL PF07303.13 EDO18230.1 - 0.022 15.5 3.7 0.022 15.5 3.7 2.1 1 1 1 2 2 2 0 Occludin homology domain KNOX2 PF03791.13 EDO18230.1 - 0.031 13.8 0.2 0.25 10.9 0.0 2.5 2 1 0 2 2 2 0 KNOX2 domain GAS PF13851.6 EDO18230.1 - 0.032 13.6 13.1 0.037 13.4 10.0 1.7 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding DHR10 PF18595.1 EDO18230.1 - 0.036 14.1 11.2 0.41 10.7 2.1 2.2 2 0 0 2 2 2 0 Designed helical repeat protein 10 domain TACC_C PF05010.14 EDO18230.1 - 0.086 12.6 12.5 1.6 8.5 1.1 2.2 1 1 1 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal APG6_N PF17675.1 EDO18230.1 - 0.095 13.2 12.3 0.045 14.3 2.3 2.2 2 0 0 2 2 2 0 Apg6 coiled-coil region FapA PF03961.13 EDO18230.1 - 0.11 11.0 6.1 0.14 10.7 6.1 1.3 1 0 0 1 1 1 0 Flagellar Assembly Protein A DASH_Dad2 PF08654.10 EDO18230.1 - 0.14 12.6 2.1 0.35 11.3 0.4 2.1 1 1 0 2 2 2 0 DASH complex subunit Dad2 DASH_Dad3 PF08656.10 EDO18230.1 - 0.16 12.1 3.1 0.23 11.6 0.9 2.2 2 0 0 2 2 2 0 DASH complex subunit Dad3 BLOC1_2 PF10046.9 EDO18230.1 - 0.21 11.9 10.2 0.099 13.0 3.0 2.5 2 1 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 SpoOE-like PF09388.10 EDO18230.1 - 0.29 11.1 4.1 6.6 6.7 0.2 3.1 2 1 1 3 3 3 0 Spo0E like sporulation regulatory protein TMPIT PF07851.13 EDO18230.1 - 0.41 9.9 5.3 0.54 9.4 5.3 1.2 1 0 0 1 1 1 0 TMPIT-like protein LOH1CR12 PF10158.9 EDO18230.1 - 0.48 10.4 3.9 1.7 8.7 0.2 2.4 2 1 1 3 3 3 0 Tumour suppressor protein Fzo_mitofusin PF04799.13 EDO18230.1 - 0.74 9.3 6.9 2.1 7.8 2.2 2.2 1 1 1 2 2 2 0 fzo-like conserved region ABC_tran_CTD PF16326.5 EDO18230.1 - 0.78 10.0 10.0 0.14 12.4 2.1 2.5 2 2 0 2 2 2 0 ABC transporter C-terminal domain Syntaxin-6_N PF09177.11 EDO18230.1 - 1 9.9 6.6 6.8 7.3 0.4 2.7 1 1 1 2 2 2 0 Syntaxin 6, N-terminal DUF4795 PF16043.5 EDO18230.1 - 1 8.9 10.1 4 7.0 10.1 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4795) Csm1_N PF18504.1 EDO18230.1 - 1.1 9.7 7.2 1.2 9.5 1.0 2.6 2 1 0 2 2 2 0 Csm1 N-terminal domain CREPT PF16566.5 EDO18230.1 - 1.2 9.3 7.3 0.35 11.0 1.5 2.1 1 1 1 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour DUF4298 PF14131.6 EDO18230.1 - 1.5 8.9 12.4 0.25 11.3 4.2 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF4298) zf-C4H2 PF10146.9 EDO18230.1 - 2 8.7 8.6 3.1 8.0 8.6 1.3 1 0 0 1 1 1 0 Zinc finger-containing protein DivIC PF04977.15 EDO18230.1 - 4.9 7.0 9.6 1.6 8.5 0.7 3.1 3 0 0 3 3 3 0 Septum formation initiator Seryl_tRNA_N PF02403.22 EDO18230.1 - 6.7 7.0 10.4 3.1 8.1 1.3 2.5 1 1 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Rho_Binding PF08912.11 EDO18230.1 - 7.6 7.4 14.3 0.4 11.5 2.8 2.5 3 0 0 3 3 2 0 Rho Binding Asp PF00026.23 EDO18231.1 - 6.2e-74 249.2 6.5 6.2e-74 249.2 6.5 1.8 2 0 0 2 2 2 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EDO18231.1 - 2e-10 41.2 3.6 2e-10 41.2 3.6 2.6 2 0 0 2 2 2 1 Xylanase inhibitor N-terminal gag-asp_proteas PF13975.6 EDO18231.1 - 0.036 14.6 0.5 1.4e+02 3.2 0.0 4.3 4 0 0 4 4 4 0 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 EDO18231.1 - 0.092 13.4 1.3 28 5.5 0.1 3.9 3 0 0 3 3 3 0 Aspartyl protease GATase PF00117.28 EDO18232.1 - 8e-12 45.3 0.0 1.3e-11 44.7 0.0 1.4 1 1 0 1 1 1 1 Glutamine amidotransferase class-I TFIID_20kDa PF03847.13 EDO18233.1 - 4.1e-32 110.5 0.4 4.1e-32 110.5 0.4 2.3 3 0 0 3 3 3 1 Transcription initiation factor TFIID subunit A Zip PF02535.22 EDO18234.1 - 1.3e-80 271.2 3.7 1.4e-79 267.7 3.7 1.9 1 1 0 1 1 1 1 ZIP Zinc transporter UNC-50 PF05216.13 EDO18234.1 - 0.0021 17.7 1.9 0.0021 17.7 1.9 2.3 2 1 0 2 2 2 1 UNC-50 family dCMP_cyt_deam_1 PF00383.23 EDO18235.1 - 2.4e-22 78.7 0.0 3.4e-22 78.2 0.0 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 EDO18235.1 - 9.1e-17 61.1 0.0 1.3e-16 60.6 0.0 1.2 1 0 0 1 1 1 1 MafB19-like deaminase APOBEC_N PF08210.11 EDO18235.1 - 0.00017 21.5 0.0 0.00027 20.9 0.0 1.2 1 0 0 1 1 1 1 APOBEC-like N-terminal domain APOBEC3 PF18771.1 EDO18235.1 - 0.00035 20.7 0.0 0.00065 19.8 0.0 1.4 1 0 0 1 1 1 1 APOBEC3 SNAD4 PF18750.1 EDO18235.1 - 0.00036 20.6 0.0 0.00062 19.9 0.0 1.3 1 0 0 1 1 1 1 Secreted Novel AID/APOBEC-like Deaminase 4 NAD1 PF18778.1 EDO18235.1 - 0.0019 18.3 0.0 0.0032 17.6 0.0 1.3 1 0 0 1 1 1 1 Novel AID APOBEC clade 1 APOBEC2 PF18772.1 EDO18235.1 - 0.0025 17.9 0.0 0.0038 17.3 0.0 1.2 1 0 0 1 1 1 1 APOBEC2 Bd3614-deam PF14439.6 EDO18235.1 - 0.0037 17.4 0.4 0.47 10.5 0.4 2.3 1 1 0 1 1 1 1 Bd3614-like deaminase APOBEC4_like PF18774.1 EDO18235.1 - 0.011 15.7 0.0 0.024 14.6 0.0 1.6 1 0 0 1 1 1 0 APOBEC4-like -AID/APOBEC-deaminase Inv-AAD PF18785.1 EDO18235.1 - 0.014 15.3 0.0 0.025 14.4 0.0 1.4 1 0 0 1 1 1 0 Invertebrate-AID/APOBEC-deaminase NAD2 PF18782.1 EDO18235.1 - 0.069 13.3 0.0 0.11 12.6 0.0 1.2 1 0 0 1 1 1 0 Novel AID APOBEC clade 2 Toxin-deaminase PF14424.6 EDO18235.1 - 0.072 13.2 0.0 0.13 12.4 0.0 1.3 1 0 0 1 1 1 0 The BURPS668_1122 family of deaminases DUF1979 PF09322.10 EDO18235.1 - 0.23 11.4 1.6 0.39 10.6 0.2 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1979) FAD_binding_2 PF00890.24 EDO18236.1 - 9.3e-125 417.0 2.2 1.2e-124 416.6 2.2 1.1 1 0 0 1 1 1 1 FAD binding domain Succ_DH_flav_C PF02910.20 EDO18236.1 - 4.7e-45 152.7 1.4 7.3e-45 152.1 1.4 1.3 1 0 0 1 1 1 1 Fumarate reductase flavoprotein C-term Pyr_redox_2 PF07992.14 EDO18236.1 - 3.2e-07 29.9 0.2 0.00014 21.2 0.1 3.1 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EDO18236.1 - 1.2e-06 27.9 3.0 0.0083 15.3 2.8 2.3 2 0 0 2 2 2 2 Glucose inhibited division protein A Thi4 PF01946.17 EDO18236.1 - 0.00012 21.4 0.2 0.0062 15.8 0.1 2.5 2 0 0 2 2 2 1 Thi4 family FAD_binding_3 PF01494.19 EDO18236.1 - 0.0036 16.6 0.1 0.0071 15.6 0.1 1.5 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 EDO18236.1 - 0.0089 15.7 2.6 0.051 13.2 2.6 2.1 1 1 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.14 EDO18236.1 - 0.051 12.3 0.5 0.37 9.4 0.2 2.3 3 0 0 3 3 3 0 HI0933-like protein Pyr_redox_3 PF13738.6 EDO18236.1 - 0.66 9.2 2.2 4.1 6.6 0.8 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_1 PF00175.21 EDO18237.1 - 7.2e-29 100.6 0.0 1e-28 100.1 0.0 1.2 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 EDO18237.1 - 4.3e-27 94.4 0.0 7.2e-27 93.7 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 EDO18237.1 - 6.1e-09 36.2 0.0 4.8e-07 30.0 0.0 2.2 1 1 1 2 2 2 2 Ferric reductase NAD binding domain Carb_kinase PF01256.17 EDO18238.1 - 1.8e-63 214.2 0.0 4.2e-63 213.1 0.0 1.5 1 1 0 1 1 1 1 Carbohydrate kinase Phos_pyr_kin PF08543.12 EDO18238.1 - 4.6e-05 22.9 0.0 7.4e-05 22.2 0.0 1.2 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase His_Phos_1 PF00300.22 EDO18239.1 - 6.6e-39 133.6 0.1 1.7e-30 106.1 0.1 2.0 1 1 1 2 2 2 2 Histidine phosphatase superfamily (branch 1) Tnp_22_dsRBD PF17490.2 EDO18239.1 - 0.12 12.4 0.0 0.29 11.2 0.0 1.6 1 0 0 1 1 1 0 L1 transposable element dsRBD-like domain RabGAP-TBC PF00566.18 EDO18240.1 - 4.4e-17 62.5 11.0 4.4e-17 62.5 11.0 1.8 1 1 0 1 1 1 1 Rab-GTPase-TBC domain DUF2423 PF10338.9 EDO18240.1 - 0.33 11.2 2.7 0.66 10.2 2.2 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF2423) LRR_1 PF00560.33 EDO18241.1 - 0.35 11.6 2.4 14 6.7 0.1 4.3 3 0 0 3 3 3 0 Leucine Rich Repeat eIF3_subunit PF08597.10 EDO18241.1 - 7.3 6.4 8.9 0.066 13.1 0.3 2.0 3 0 0 3 3 3 0 Translation initiation factor eIF3 subunit Nsp1_C PF05064.13 EDO18242.1 - 1.7e-40 137.5 6.1 1.7e-40 137.5 6.1 1.9 1 1 1 2 2 2 1 Nsp1-like C-terminal region Baculo_p24 PF05073.12 EDO18242.1 - 0.011 15.5 3.8 0.021 14.6 3.8 1.5 1 0 0 1 1 1 0 Baculovirus P24 capsid protein DNA_primase_lrg PF04104.14 EDO18242.1 - 0.038 13.4 0.5 0.061 12.7 0.5 1.3 1 0 0 1 1 1 0 Eukaryotic and archaeal DNA primase, large subunit STAT_alpha PF01017.20 EDO18242.1 - 0.053 13.4 5.8 0.11 12.4 5.8 1.4 1 0 0 1 1 1 0 STAT protein, all-alpha domain APG6_N PF17675.1 EDO18242.1 - 0.18 12.3 15.8 0.35 11.4 15.8 1.5 1 0 0 1 1 1 0 Apg6 coiled-coil region Caudo_TAP PF02413.17 EDO18242.1 - 0.27 11.4 6.6 0.63 10.2 6.2 1.9 1 1 0 1 1 1 0 Caudovirales tail fibre assembly protein, lambda gpK Laminin_II PF06009.12 EDO18242.1 - 0.58 10.2 15.4 0.85 9.6 8.9 2.8 1 1 2 3 3 3 0 Laminin Domain II CorA PF01544.18 EDO18242.1 - 0.65 9.3 4.9 1 8.6 4.9 1.3 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein Exonuc_VII_L PF02601.15 EDO18242.1 - 1.6 8.2 10.6 4 6.9 10.6 1.6 1 1 0 1 1 1 0 Exonuclease VII, large subunit PRP9_N PF16958.5 EDO18242.1 - 2.7 8.0 9.1 6 6.9 8.6 1.9 1 1 0 1 1 1 0 Pre-mRNA-splicing factor PRP9 N-terminus Syntaxin-6_N PF09177.11 EDO18242.1 - 4 8.1 9.5 23 5.6 1.2 2.7 1 1 1 2 2 2 0 Syntaxin 6, N-terminal DUF87 PF01935.17 EDO18242.1 - 4.5 7.3 9.8 29 4.6 9.8 2.0 1 1 0 1 1 1 0 Helicase HerA, central domain DUF1664 PF07889.12 EDO18242.1 - 7.9 6.5 7.0 9.5 6.3 1.7 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) FapA PF03961.13 EDO18242.1 - 8.8 4.8 12.1 5.1 5.6 2.3 1.9 1 1 1 2 2 2 0 Flagellar Assembly Protein A Nup192 PF11894.8 EDO18243.1 - 0 1677.5 83.0 0 1677.4 83.0 1.0 1 0 0 1 1 1 1 Nuclear pore complex scaffold, nucleoporins 186/192/205 TPR_10 PF13374.6 EDO18243.1 - 0.23 11.4 0.1 0.58 10.1 0.1 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat SAM_decarbox PF01536.16 EDO18244.1 - 7.4e-121 403.5 6.2 8.6e-121 403.3 6.2 1.0 1 0 0 1 1 1 1 Adenosylmethionine decarboxylase EamA PF00892.20 EDO18246.1 - 2.8e-26 92.3 34.4 2.8e-15 56.7 9.0 2.2 2 0 0 2 2 2 2 EamA-like transporter family TPT PF03151.16 EDO18246.1 - 0.00079 18.9 3.6 0.00079 18.9 3.6 2.0 2 0 0 2 2 2 1 Triose-phosphate Transporter family GFD1 PF17331.2 EDO18247.1 - 1.2e-07 31.6 10.9 1.2e-07 31.6 10.9 3.4 3 0 0 3 3 3 2 GFD1 mRNA transport factor Rota_VP2 PF05087.12 EDO18247.1 - 4.5 5.3 14.4 5.3 5.0 14.4 1.0 1 0 0 1 1 1 0 Rotavirus VP2 protein ApbA PF02558.16 EDO18248.1 - 1.6e-30 105.7 0.0 2.3e-30 105.2 0.0 1.2 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA ApbA_C PF08546.11 EDO18248.1 - 5.6e-23 81.5 0.0 9e-23 80.8 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal F420_oxidored PF03807.17 EDO18248.1 - 0.0011 19.4 0.0 0.002 18.6 0.0 1.5 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_Gly3P_dh_N PF01210.23 EDO18248.1 - 0.0068 16.4 0.0 0.012 15.6 0.0 1.4 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus BBS2_C PF14782.6 EDO18248.1 - 0.0088 14.8 0.3 0.013 14.3 0.3 1.1 1 0 0 1 1 1 1 Ciliary BBSome complex subunit 2, C-terminal Sacchrp_dh_NADP PF03435.18 EDO18248.1 - 0.12 12.6 0.0 0.24 11.7 0.0 1.6 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain AA_permease PF00324.21 EDO18249.1 - 2.3e-154 514.5 34.3 2.9e-154 514.2 34.3 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EDO18249.1 - 4.7e-41 141.0 36.4 5.9e-41 140.7 36.4 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EDO18250.1 - 1.4e-151 505.4 45.2 1.7e-151 505.1 45.2 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EDO18250.1 - 6.1e-40 137.3 46.0 7.7e-40 137.0 46.0 1.0 1 0 0 1 1 1 1 Amino acid permease DUF4781 PF16013.5 EDO18250.1 - 0.24 10.2 1.2 0.43 9.3 1.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4781) KdpC PF02669.15 EDO18251.1 - 0.22 11.3 0.0 0.27 11.1 0.0 1.3 1 1 0 1 1 1 0 K+-transporting ATPase, c chain 6PF2K PF01591.18 EDO18252.1 - 1.4e-48 165.1 4.9 2.4e-48 164.4 4.9 1.3 1 0 0 1 1 1 1 6-phosphofructo-2-kinase AAA_33 PF13671.6 EDO18252.1 - 7.8e-05 22.9 0.0 0.00015 22.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain KTI12 PF08433.10 EDO18252.1 - 0.00031 20.3 0.1 0.00031 20.3 0.1 2.6 3 1 0 3 3 3 1 Chromatin associated protein KTI12 WRW PF10206.9 EDO18252.1 - 0.00059 20.2 0.8 0.0014 18.9 0.8 1.7 1 0 0 1 1 1 1 Mitochondrial F1F0-ATP synthase, subunit f AAA_18 PF13238.6 EDO18252.1 - 0.0045 17.5 1.8 0.03 14.9 0.0 2.6 3 1 0 3 3 3 1 AAA domain AAA_17 PF13207.6 EDO18252.1 - 0.22 12.0 0.0 0.38 11.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain PDT PF00800.18 EDO18253.1 - 2.3e-50 171.0 0.8 3e-50 170.6 0.8 1.1 1 0 0 1 1 1 1 Prephenate dehydratase DUF5014 PF16406.5 EDO18253.1 - 0.0042 17.3 0.0 0.014 15.7 0.0 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF5014) ACT_4 PF13291.6 EDO18253.1 - 0.036 14.7 0.3 1.2 9.7 0.0 2.7 2 1 0 2 2 2 0 ACT domain Rotamase_3 PF13616.6 EDO18254.1 - 0.014 15.9 0.2 0.042 14.4 0.2 1.9 1 0 0 1 1 1 0 PPIC-type PPIASE domain HTH_57 PF18679.1 EDO18254.1 - 0.32 11.3 1.4 1.2 9.4 0.0 2.5 3 0 0 3 3 3 0 ThcOx helix turn helix domain DUF1752 PF08550.10 EDO18255.1 - 6.1e-08 32.4 0.6 2.4e-07 30.5 0.6 2.2 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) Brix PF04427.18 EDO18256.1 - 3.8e-28 98.9 0.1 4.9e-28 98.6 0.1 1.1 1 0 0 1 1 1 1 Brix domain PsaF PF17550.2 EDO18257.1 - 0.06 12.8 0.4 0.14 11.7 0.4 1.5 1 0 0 1 1 1 0 Family of unknown function Nup96 PF12110.8 EDO18257.1 - 0.28 10.3 1.6 0.43 9.6 1.6 1.3 1 0 0 1 1 1 0 Nuclear protein 96 2-oxoacid_dh PF00198.23 EDO18258.1 - 1.7e-77 260.0 0.5 2.5e-77 259.5 0.5 1.2 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 EDO18258.1 - 1.4e-17 63.3 0.1 3.2e-17 62.1 0.1 1.7 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.17 EDO18258.1 - 5.3e-14 52.3 0.2 5.3e-14 52.3 0.2 2.1 2 0 0 2 2 2 1 e3 binding domain ATPgrasp_TupA PF14305.6 EDO18258.1 - 0.038 13.7 0.1 0.07 12.9 0.1 1.3 1 0 0 1 1 1 0 TupA-like ATPgrasp FliX PF10768.9 EDO18258.1 - 0.09 13.3 0.2 5.6 7.5 0.0 2.3 2 0 0 2 2 2 0 Class II flagellar assembly regulator DUF3614 PF12267.8 EDO18258.1 - 0.19 12.2 3.0 0.35 11.4 0.1 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF3614) Blt1 PF12754.7 EDO18258.1 - 0.22 11.8 6.1 0.17 12.2 0.8 2.4 2 0 0 2 2 2 0 Blt1 N-terminal domain dbPDZ_assoc PF16610.5 EDO18258.1 - 7.7 6.8 10.2 0.89 9.8 5.2 2.1 2 0 0 2 2 2 0 Unstructured region between two PDZ domains on Dlg5 Mito_carr PF00153.27 EDO18259.1 - 5.2e-60 199.4 6.9 1.4e-22 79.4 0.9 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Ribosomal_L13 PF00572.18 EDO18260.1 - 3.9e-11 43.3 1.2 1.9e-09 37.8 0.1 2.5 2 1 0 2 2 2 1 Ribosomal protein L13 Forkhead PF00250.18 EDO18261.1 - 9.9e-33 112.3 7.3 1.1e-32 112.2 0.4 3.4 3 0 0 3 3 3 1 Forkhead domain FHA PF00498.26 EDO18261.1 - 2.4e-10 40.6 0.2 1.2e-09 38.4 0.1 2.4 2 0 0 2 2 2 1 FHA domain Linker_histone PF00538.19 EDO18261.1 - 0.00029 21.1 0.5 0.0014 19.0 0.2 2.3 2 0 0 2 2 2 1 linker histone H1 and H5 family Rotamase_3 PF13616.6 EDO18261.1 - 0.052 14.1 0.2 0.21 12.1 0.0 2.1 2 0 0 2 2 2 0 PPIC-type PPIASE domain Fungal_trans PF04082.18 EDO18262.1 - 1.6e-26 92.9 5.4 1.6e-26 92.9 5.4 3.5 2 1 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDO18262.1 - 3.2e-11 43.1 12.3 5.6e-11 42.4 12.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MMS19_C PF12460.8 EDO18263.1 - 1.9e-83 281.0 14.3 1.9e-83 281.0 14.3 3.6 4 1 0 5 5 5 1 RNAPII transcription regulator C-terminal MMS19_N PF14500.6 EDO18263.1 - 6.6e-81 271.7 5.2 6.7e-78 261.9 0.2 4.3 4 1 0 4 4 4 2 Dos2-interacting transcription regulator of RNA-Pol-II RTP1_C1 PF10363.9 EDO18263.1 - 0.0027 17.9 1.2 0.015 15.5 0.1 3.0 2 0 0 2 2 2 1 Required for nuclear transport of RNA pol II C-terminus 1 HEAT_EZ PF13513.6 EDO18263.1 - 0.0051 17.3 0.7 23 5.6 0.0 5.0 6 0 0 6 6 5 0 HEAT-like repeat Vac14_Fab1_bd PF12755.7 EDO18263.1 - 0.0059 17.2 0.3 0.15 12.7 0.0 3.5 3 1 0 3 3 2 1 Vacuolar 14 Fab1-binding region NUDIX_2 PF13869.6 EDO18263.1 - 0.009 15.6 0.0 0.024 14.2 0.0 1.7 1 0 0 1 1 1 1 Nucleotide hydrolase HEAT_2 PF13646.6 EDO18263.1 - 0.0092 16.3 0.0 0.13 12.7 0.0 3.0 3 1 0 3 3 3 1 HEAT repeats DUF4325 PF14213.6 EDO18263.1 - 0.016 14.9 0.5 3 7.6 0.0 3.7 3 0 0 3 3 3 0 STAS-like domain of unknown function (DUF4325) Condensin2nSMC PF12422.8 EDO18263.1 - 0.017 15.3 0.9 0.094 12.9 0.2 2.8 2 0 0 2 2 2 0 Condensin II non structural maintenance of chromosomes subunit HEAT PF02985.22 EDO18263.1 - 0.028 14.7 5.8 18 5.9 0.0 5.7 5 0 0 5 5 5 0 HEAT repeat ParcG PF10274.9 EDO18263.1 - 0.04 14.0 5.4 0.15 12.2 0.9 3.6 3 1 0 3 3 3 0 Parkin co-regulated protein Ipi1_N PF12333.8 EDO18263.1 - 0.062 13.9 0.2 1.9 9.1 0.0 3.4 3 1 1 4 4 3 0 Rix1 complex component involved in 60S ribosome maturation Toxin_28 PF08115.11 EDO18263.1 - 0.072 13.0 0.2 0.17 11.8 0.2 1.6 1 0 0 1 1 1 0 SFI toxin family DUF1258 PF06869.12 EDO18263.1 - 0.088 12.3 0.4 0.17 11.3 0.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1258) Tti2 PF10521.9 EDO18263.1 - 0.2 11.1 12.6 0.2 11.2 0.2 4.1 4 2 3 7 7 7 0 Tti2 family RRT14 PF17075.5 EDO18264.1 - 9.8e-61 205.3 30.5 1.2e-60 205.1 30.5 1.0 1 0 0 1 1 1 1 Regular of rDNA transcription protein 14 SNF2_N PF00176.23 EDO18266.1 - 1.7e-76 257.2 0.7 4.6e-76 255.8 0.7 1.7 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EDO18266.1 - 1.4e-22 80.1 0.5 2.4e-19 69.7 0.0 3.6 3 0 0 3 3 3 2 Helicase conserved C-terminal domain Bromodomain PF00439.25 EDO18266.1 - 2e-20 72.6 0.1 7.1e-20 70.9 0.1 2.1 1 0 0 1 1 1 1 Bromodomain ResIII PF04851.15 EDO18266.1 - 1e-10 41.9 0.0 1e-10 41.9 0.0 3.1 2 1 1 3 3 3 1 Type III restriction enzyme, res subunit SnAC PF14619.6 EDO18266.1 - 2.6e-08 34.3 5.8 3.3e-08 34.0 0.2 4.2 2 1 1 3 3 3 1 Snf2-ATP coupling, chromatin remodelling complex HSA PF07529.13 EDO18266.1 - 9.6e-07 29.0 7.5 9.6e-07 29.0 7.5 2.9 3 0 0 3 3 3 1 HSA Transket_pyr PF02779.24 EDO18267.1 - 2.2e-65 219.7 0.0 3.6e-65 219.0 0.0 1.4 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain E1_dh PF00676.20 EDO18267.1 - 1.1e-59 201.9 0.0 1.6e-59 201.4 0.0 1.2 1 0 0 1 1 1 1 Dehydrogenase E1 component OxoGdeHyase_C PF16870.5 EDO18267.1 - 1e-50 171.4 0.0 1.6e-50 170.7 0.0 1.3 1 0 0 1 1 1 1 2-oxoglutarate dehydrogenase C-terminal 2-oxogl_dehyd_N PF16078.5 EDO18267.1 - 2.9e-17 62.0 2.1 2.9e-17 62.0 2.1 2.0 2 0 0 2 2 2 1 2-oxoglutarate dehydrogenase N-terminus adh_short PF00106.25 EDO18268.1 - 2.9e-47 160.7 0.0 3.8e-47 160.3 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EDO18268.1 - 3.3e-31 108.6 0.0 4.1e-31 108.3 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EDO18268.1 - 5e-09 36.3 0.0 7.5e-09 35.8 0.0 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EDO18268.1 - 1.5e-05 24.6 0.0 4.4e-05 23.0 0.0 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 EDO18268.1 - 0.0018 17.4 0.0 0.0028 16.8 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain DUF1776 PF08643.10 EDO18268.1 - 0.0037 16.7 0.0 0.1 11.9 0.0 2.4 2 1 0 2 2 2 1 Fungal family of unknown function (DUF1776) RPAP1_N PF08621.10 EDO18268.1 - 0.059 13.1 1.1 0.13 12.0 1.1 1.6 1 0 0 1 1 1 0 RPAP1-like, N-terminal GDP_Man_Dehyd PF16363.5 EDO18268.1 - 0.065 12.6 0.0 0.24 10.8 0.0 1.8 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 EDO18268.1 - 0.16 11.9 0.0 0.24 11.2 0.0 1.3 1 0 0 1 1 1 0 NAD(P)H-binding Mem_trans PF03547.18 EDO18269.1 - 0.6 8.4 3.5 0.75 8.1 3.5 1.3 1 0 0 1 1 1 0 Membrane transport protein MFS_1 PF07690.16 EDO18270.1 - 6.5e-40 137.1 17.7 6.5e-40 137.1 17.7 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EDO18270.1 - 1.4e-13 50.6 6.3 1.4e-13 50.6 6.3 2.7 3 0 0 3 3 3 1 Sugar (and other) transporter TRI12 PF06609.13 EDO18270.1 - 0.00022 19.8 3.6 0.00033 19.2 3.6 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) PMT_4TMC PF16192.5 EDO18270.1 - 0.022 14.3 1.2 0.097 12.2 1.2 2.2 1 1 0 1 1 1 0 C-terminal four TMM region of protein-O-mannosyltransferase MFS_3 PF05977.13 EDO18270.1 - 0.062 11.7 3.9 0.11 10.8 3.9 1.4 1 0 0 1 1 1 0 Transmembrane secretion effector DUF2333 PF10095.9 EDO18270.1 - 0.13 11.3 0.0 0.26 10.3 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2333) Ras PF00071.22 EDO18271.1 - 3.3e-59 199.1 0.0 3.9e-59 198.9 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EDO18271.1 - 4.9e-23 81.6 0.0 7.6e-23 81.0 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EDO18271.1 - 4.1e-10 39.4 0.0 5.8e-10 38.9 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 EDO18271.1 - 0.00034 20.1 0.0 0.00055 19.4 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 EDO18271.1 - 0.00082 19.4 0.0 0.0026 17.8 0.0 1.9 1 1 1 2 2 2 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EDO18271.1 - 0.0022 17.4 0.0 0.0032 16.9 0.0 1.4 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region G-alpha PF00503.20 EDO18271.1 - 0.0035 16.6 0.0 0.012 14.8 0.0 1.3 1 1 0 1 1 1 1 G-protein alpha subunit RsgA_GTPase PF03193.16 EDO18271.1 - 0.022 14.6 0.1 4.8 7.0 0.0 2.3 2 0 0 2 2 2 0 RsgA GTPase AAA_15 PF13175.6 EDO18271.1 - 0.023 14.4 0.3 0.039 13.7 0.3 1.3 1 1 0 1 1 1 0 AAA ATPase domain ABC_tran PF00005.27 EDO18271.1 - 0.062 13.8 0.0 0.1 13.1 0.0 1.5 1 1 0 1 1 1 0 ABC transporter Insulin_TMD PF17870.1 EDO18272.1 - 0.0014 18.7 0.0 0.0029 17.6 0.0 1.5 1 0 0 1 1 1 1 Insulin receptor trans-membrane segment SdrD_B PF17210.3 EDO18272.1 - 0.031 14.5 0.1 0.082 13.1 0.1 1.7 1 0 0 1 1 1 0 SdrD B-like domain TMEM154 PF15102.6 EDO18272.1 - 0.046 13.6 1.1 0.081 12.8 0.0 1.9 2 0 0 2 2 2 0 TMEM154 protein family TRP PF06011.12 EDO18272.1 - 0.12 11.1 0.0 0.15 10.8 0.0 1.1 1 0 0 1 1 1 0 Transient receptor potential (TRP) ion channel Aminotran_1_2 PF00155.21 EDO18273.1 - 1.3e-62 212.0 0.0 1.5e-62 211.9 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II NUP214 PF16755.5 EDO18274.1 - 7.7e-165 548.4 8.6 7.7e-165 548.4 8.6 2.5 2 0 0 2 2 2 1 Nucleoporin or Nuclear pore complex subunit NUP214=Nup159 S_100 PF01023.19 EDO18274.1 - 0.073 12.8 0.2 0.18 11.6 0.2 1.7 1 0 0 1 1 1 0 S-100/ICaBP type calcium binding domain Vac7 PF12751.7 EDO18275.1 - 5.6e-26 91.9 11.0 2e-17 63.7 0.0 3.9 4 1 1 5 5 5 2 Vacuolar segregation subunit 7 DSPc PF00782.20 EDO18276.1 - 1.4e-34 118.7 0.1 3.1e-34 117.7 0.1 1.6 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 EDO18276.1 - 0.013 15.6 0.0 0.023 14.8 0.0 1.4 1 0 0 1 1 1 0 Inositol hexakisphosphate Y_phosphatase PF00102.27 EDO18276.1 - 0.024 14.2 0.0 0.044 13.4 0.0 1.4 1 0 0 1 1 1 0 Protein-tyrosine phosphatase Ank_2 PF12796.7 EDO18277.1 - 6e-37 126.1 5.9 8.9e-18 64.7 0.8 3.5 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EDO18277.1 - 1.5e-30 104.9 1.4 1.8e-08 34.5 0.0 3.9 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 EDO18277.1 - 1.6e-27 95.5 0.0 1.1e-08 35.4 0.0 5.2 4 1 1 5 5 5 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EDO18277.1 - 2.6e-23 79.6 0.0 5.8e-05 23.2 0.2 6.2 6 0 0 6 6 6 4 Ankyrin repeat Ank PF00023.30 EDO18277.1 - 4e-22 77.6 3.4 2.3e-05 24.6 0.4 5.3 5 0 0 5 5 5 3 Ankyrin repeat DUF249 PF03158.13 EDO18277.1 - 0.015 15.0 0.0 0.58 9.8 0.0 2.3 2 0 0 2 2 2 0 Multigene family 530 protein COX4 PF02936.14 EDO18278.1 - 3.3e-30 104.9 0.2 3.7e-30 104.8 0.2 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit IV DUF3042 PF11240.8 EDO18278.1 - 0.68 10.0 2.4 1.3 9.1 2.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3042) Sec23_trunk PF04811.15 EDO18280.1 - 4e-61 206.7 0.6 1.1e-60 205.3 0.1 1.9 2 0 0 2 2 2 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.15 EDO18280.1 - 2.5e-19 69.0 0.4 6.4e-19 67.7 0.4 1.8 1 0 0 1 1 1 1 Sec23/Sec24 helical domain zf-Sec23_Sec24 PF04810.15 EDO18280.1 - 7.2e-15 54.8 8.0 1.4e-14 53.9 8.0 1.5 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Sec23_BS PF08033.12 EDO18280.1 - 9.2e-15 55.2 0.2 1.7e-14 54.3 0.2 1.5 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain Gelsolin PF00626.22 EDO18280.1 - 5.9e-07 29.3 0.0 1.3e-06 28.2 0.0 1.6 1 0 0 1 1 1 1 Gelsolin repeat Swi6_N PF18530.1 EDO18280.1 - 0.17 12.0 0.0 0.42 10.8 0.0 1.6 1 0 0 1 1 1 0 Swi6 N-terminal domain Metallopep PF12044.8 EDO18281.1 - 2.1e-172 573.5 0.0 2.6e-172 573.3 0.0 1.1 1 0 0 1 1 1 1 Putative peptidase family Jacalin PF01419.17 EDO18281.1 - 4.6e-08 33.1 0.0 1.2e-07 31.8 0.0 1.8 1 1 0 1 1 1 1 Jacalin-like lectin domain Peptidase_M66 PF10462.9 EDO18281.1 - 0.026 13.5 0.1 0.05 12.6 0.1 1.4 1 0 0 1 1 1 0 Peptidase M66 Reprolysin_3 PF13582.6 EDO18281.1 - 0.031 14.8 0.1 0.068 13.7 0.1 1.6 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.6 EDO18281.1 - 0.052 13.7 0.1 0.085 13.0 0.1 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12 6PF2K PF01591.18 EDO18282.1 - 4.4e-78 261.6 0.1 7.8e-78 260.8 0.1 1.4 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 EDO18282.1 - 1.1e-34 119.8 0.0 4.9e-29 101.4 0.0 2.3 2 0 0 2 2 2 2 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.6 EDO18282.1 - 3.2e-05 24.1 0.0 7e-05 23.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EDO18282.1 - 0.00065 20.3 0.0 0.0016 18.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.6 EDO18282.1 - 0.0049 17.3 0.0 0.043 14.2 0.0 2.5 2 0 0 2 2 2 1 AAA domain KTI12 PF08433.10 EDO18282.1 - 0.0075 15.8 0.0 0.014 14.8 0.0 1.4 1 0 0 1 1 1 1 Chromatin associated protein KTI12 APS_kinase PF01583.20 EDO18282.1 - 0.0081 16.1 0.0 0.017 15.0 0.0 1.5 1 0 0 1 1 1 1 Adenylylsulphate kinase Pox_A28 PF04584.14 EDO18282.1 - 0.011 15.9 0.0 0.027 14.7 0.0 1.6 1 0 0 1 1 1 0 Poxvirus A28 family Arb2 PF09757.9 EDO18283.1 - 2.1e-87 292.5 0.0 2.8e-87 292.1 0.0 1.2 1 0 0 1 1 1 1 Arb2 domain Hist_deacetyl PF00850.19 EDO18283.1 - 4.5e-86 289.1 0.0 9.3e-86 288.1 0.0 1.5 2 0 0 2 2 2 1 Histone deacetylase domain Peptidase_G2 PF11962.8 EDO18283.1 - 0.019 14.4 1.4 0.057 12.8 0.1 2.0 2 0 0 2 2 2 0 Peptidase_G2, IMC autoproteolytic cleavage domain Pkinase PF00069.25 EDO18284.1 - 7.7e-40 136.9 0.1 1.2e-39 136.3 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO18284.1 - 7e-31 107.4 0.0 1.1e-30 106.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EDO18284.1 - 3.7e-05 23.2 0.0 7.1e-05 22.3 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EDO18284.1 - 0.00017 21.6 0.0 0.099 12.6 0.0 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kinase-like PF14531.6 EDO18284.1 - 0.00081 18.8 0.0 0.0015 17.9 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Fructosamin_kin PF03881.14 EDO18284.1 - 0.11 11.6 0.0 0.46 9.6 0.0 1.9 1 1 1 2 2 2 0 Fructosamine kinase CLTH PF10607.9 EDO18285.1 - 4.1e-31 107.9 1.9 4.1e-31 107.9 1.9 2.2 2 0 0 2 2 2 1 CTLH/CRA C-terminal to LisH motif domain U-box PF04564.15 EDO18285.1 - 0.0017 18.5 0.1 0.011 15.9 0.0 2.4 2 0 0 2 2 2 1 U-box domain Beach PF02138.18 EDO18285.1 - 0.024 14.0 1.5 0.037 13.4 0.4 1.9 2 0 0 2 2 2 0 Beige/BEACH domain Rad50_zn_hook PF04423.14 EDO18285.1 - 0.57 10.1 0.0 0.57 10.1 0.0 3.0 3 1 1 4 4 4 0 Rad50 zinc hook motif Iso_dh PF00180.20 EDO18286.1 - 1.6e-74 251.1 0.2 2e-74 250.8 0.2 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase PDEase_I_N PF08499.12 EDO18287.1 - 0.032 14.1 0.8 0.62 9.9 0.1 3.3 3 0 0 3 3 3 0 3'5'-cyclic nucleotide phosphodiesterase N-terminal Mem_trans PF03547.18 EDO18287.1 - 1.7 6.9 7.2 2.7 6.3 7.2 1.4 1 0 0 1 1 1 0 Membrane transport protein COG6 PF06419.11 EDO18288.1 - 7.1e-150 500.2 25.9 7.1e-150 500.2 25.9 1.6 2 0 0 2 2 2 1 Conserved oligomeric complex COG6 zf-AD PF07776.15 EDO18288.1 - 0.014 15.7 0.1 0.2 11.9 0.0 2.9 2 0 0 2 2 2 0 Zinc-finger associated domain (zf-AD) DUF2722 PF10846.8 EDO18289.1 - 4.1e-67 227.2 22.2 1.4e-64 218.8 22.2 2.5 1 1 0 1 1 1 1 Protein of unknown function (DUF2722) Tox-PL-2 PF15643.6 EDO18289.1 - 0.28 11.3 2.8 13 6.0 0.1 2.8 3 0 0 3 3 3 0 Papain fold toxin 2 PRA1 PF03208.19 EDO18290.1 - 8.9e-41 138.9 0.5 1.1e-40 138.5 0.5 1.1 1 0 0 1 1 1 1 PRA1 family protein DUF2207 PF09972.9 EDO18290.1 - 0.026 13.3 0.5 0.032 13.0 0.5 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Peptidase_M1 PF01433.20 EDO18291.1 - 3e-50 170.8 0.7 5.8e-50 169.9 0.7 1.5 1 0 0 1 1 1 1 Peptidase family M1 domain Leuk-A4-hydro_C PF09127.11 EDO18291.1 - 3.5e-36 123.7 1.2 7.2e-36 122.7 0.4 2.0 2 0 0 2 2 2 1 Leukotriene A4 hydrolase, C-terminal Peptidase_M1_N PF17900.1 EDO18291.1 - 1.8e-33 116.3 0.2 3.9e-33 115.2 0.2 1.5 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain Peptidase_MA_2 PF13485.6 EDO18291.1 - 0.02 14.6 0.7 0.16 11.6 0.7 2.1 1 1 1 2 2 2 0 Peptidase MA superfamily UBA_6 PF18039.1 EDO18291.1 - 0.2 11.6 0.2 0.74 9.8 0.0 2.0 2 0 0 2 2 2 0 UBA-like domain Peptidase_M61 PF05299.12 EDO18291.1 - 0.21 12.0 1.3 4.3 7.8 1.3 2.4 1 1 0 1 1 1 0 M61 glycyl aminopeptidase PH PF00169.29 EDO18292.1 - 7e-11 42.6 0.6 1.6e-10 41.4 0.6 1.7 1 0 0 1 1 1 1 PH domain ALG11_N PF15924.5 EDO18293.1 - 3.1e-80 269.2 1.3 5.8e-80 268.3 1.3 1.5 1 0 0 1 1 1 1 ALG11 mannosyltransferase N-terminus Glycos_transf_1 PF00534.20 EDO18293.1 - 2.2e-13 50.1 0.0 4.4e-13 49.1 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 EDO18293.1 - 0.0014 19.0 0.0 0.0026 18.2 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 EDO18293.1 - 0.0018 18.3 0.0 0.0031 17.5 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase Family 4 SpoVAD PF07451.11 EDO18293.1 - 0.13 10.9 0.0 0.27 9.9 0.0 1.4 1 0 0 1 1 1 0 Stage V sporulation protein AD (SpoVAD) R3H PF01424.22 EDO18294.1 - 1.5e-20 72.9 0.1 1e-19 70.2 0.0 2.3 2 0 0 2 2 2 1 R3H domain zf-NF-X1 PF01422.17 EDO18294.1 - 1.3e-10 41.1 56.3 7.6e-06 25.9 14.4 11.7 10 1 0 10 10 10 4 NF-X1 type zinc finger Latrotoxin_C PF15658.6 EDO18294.1 - 0.18 11.5 0.2 0.42 10.4 0.2 1.6 1 0 0 1 1 1 0 Latrotoxin C-terminal domain UTP25 PF06862.12 EDO18295.1 - 1.2e-201 670.6 16.5 1.2e-201 670.6 16.5 1.7 2 0 0 2 2 2 1 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 DEAD PF00270.29 EDO18295.1 - 3.6e-06 26.9 0.6 0.04 13.7 0.0 2.7 3 0 0 3 3 3 2 DEAD/DEAH box helicase Helicase_C PF00271.31 EDO18295.1 - 0.0019 18.5 0.7 0.32 11.3 0.1 3.2 2 1 1 3 3 3 1 Helicase conserved C-terminal domain Ribosomal_L31 PF01197.18 EDO18296.1 - 0.0057 16.9 0.1 0.015 15.5 0.0 1.7 2 0 0 2 2 2 1 Ribosomal protein L31 DIM1 PF02966.16 EDO18297.1 - 3.3e-68 227.5 0.7 3.8e-68 227.4 0.7 1.0 1 0 0 1 1 1 1 Mitosis protein DIM1 Thioredoxin PF00085.20 EDO18297.1 - 2.8e-05 24.1 0.1 3.7e-05 23.7 0.1 1.2 1 0 0 1 1 1 1 Thioredoxin DUF3192 PF11399.8 EDO18297.1 - 0.09 12.7 0.1 0.12 12.3 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3192) HGTP_anticodon PF03129.20 EDO18298.1 - 3.8e-21 75.0 0.8 1.9e-20 72.8 0.1 2.6 2 0 0 2 2 2 1 Anticodon binding domain tRNA-synt_2b PF00587.25 EDO18298.1 - 6.6e-07 29.5 0.0 3.5e-06 27.1 0.0 2.0 2 1 0 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) RRM_1 PF00076.22 EDO18299.1 - 9.5e-14 51.0 0.1 3.7e-08 33.1 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) VIT1 PF01988.19 EDO18299.1 - 0.62 9.9 1.8 2.2 8.1 1.5 1.8 1 1 1 2 2 2 0 VIT family GTP_EFTU PF00009.27 EDO18300.1 - 2.5e-54 183.8 0.0 3.6e-54 183.3 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 EDO18300.1 - 4.3e-40 136.5 0.0 9e-40 135.5 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 EDO18300.1 - 6.5e-14 52.1 1.4 6.5e-14 52.1 1.4 2.2 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EDO18300.1 - 0.00022 21.3 0.1 0.0061 16.6 0.1 2.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D4 PF14578.6 EDO18300.1 - 0.56 10.1 5.1 0.088 12.7 0.5 2.0 3 0 0 3 3 3 0 Elongation factor Tu domain 4 CIMR PF00878.18 EDO18302.1 - 1.3e-07 31.7 1.3 3.9e-05 23.7 0.1 3.2 2 1 1 3 3 3 1 Cation-independent mannose-6-phosphate receptor repeat PRKCSH_1 PF13015.6 EDO18302.1 - 4.8e-05 23.1 0.1 8.4e-05 22.3 0.1 1.3 1 0 0 1 1 1 1 Glucosidase II beta subunit-like protein Man-6-P_recep PF02157.15 EDO18302.1 - 0.00052 19.2 0.1 0.00073 18.7 0.1 1.2 1 0 0 1 1 1 1 Mannose-6-phosphate receptor Herpes_capsid PF06112.11 EDO18303.1 - 2.8 8.0 7.2 3.1 7.8 7.2 1.0 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein HHH_6 PF14579.6 EDO18304.1 - 0.08 13.2 0.0 0.14 12.4 0.0 1.4 1 0 0 1 1 1 0 Helix-hairpin-helix motif DUF3074 PF11274.8 EDO18305.1 - 7.7e-27 94.5 0.1 1e-26 94.1 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3074) Transketolase_N PF00456.21 EDO18306.1 - 1.3e-150 501.1 0.0 1.7e-150 500.6 0.0 1.2 1 0 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain Transket_pyr PF02779.24 EDO18306.1 - 5.5e-45 153.2 0.0 8.8e-45 152.5 0.0 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 EDO18306.1 - 5.9e-15 55.2 0.0 1.2e-14 54.3 0.0 1.6 1 0 0 1 1 1 1 Transketolase, C-terminal domain DXP_synthase_N PF13292.6 EDO18306.1 - 6.9e-05 22.2 0.0 0.00015 21.1 0.0 1.5 1 1 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase TPP_enzyme_C PF02775.21 EDO18306.1 - 0.029 14.2 0.1 0.13 12.1 0.1 2.1 1 1 0 1 1 1 0 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain DUF4923 PF16270.5 EDO18306.1 - 0.17 11.7 0.0 0.92 9.3 0.0 2.0 2 0 0 2 2 2 0 Lipocalin-like domain (DUF4923) LMWPc PF01451.21 EDO18307.1 - 8.8e-47 159.1 0.0 1e-46 158.9 0.0 1.0 1 0 0 1 1 1 1 Low molecular weight phosphotyrosine protein phosphatase Ammonium_transp PF00909.21 EDO18308.1 - 5.9e-126 420.4 27.8 6.7e-126 420.2 27.8 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family Prefoldin_2 PF01920.20 EDO18310.1 - 5.4e-21 74.5 9.1 6.5e-21 74.3 9.1 1.1 1 0 0 1 1 1 1 Prefoldin subunit WXG100 PF06013.12 EDO18310.1 - 0.082 13.1 0.4 0.17 12.2 0.0 1.6 2 0 0 2 2 2 0 Proteins of 100 residues with WXG DUF4065 PF13274.6 EDO18311.1 - 0.032 15.1 0.4 0.05 14.5 0.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4065) PDGF_N PF04692.13 EDO18311.1 - 2.6 8.9 8.4 4.8 8.0 0.6 2.3 2 0 0 2 2 2 0 Platelet-derived growth factor, N terminal region zf-AN1 PF01428.16 EDO18312.1 - 4.4e-10 39.5 14.3 7.9e-10 38.7 14.3 1.3 1 0 0 1 1 1 1 AN1-like Zinc finger CBM39 PF15886.5 EDO18312.1 - 0.3 11.0 2.6 0.36 10.8 0.2 2.3 2 2 0 2 2 2 0 Carbohydrate binding domain (family 32) WLM PF08325.10 EDO18313.1 - 1.1e-60 205.0 0.2 1.3e-60 204.8 0.2 1.1 1 0 0 1 1 1 1 WLM domain DUF45 PF01863.17 EDO18313.1 - 0.064 13.3 0.0 0.13 12.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function DUF45 INSIG PF07281.12 EDO18314.1 - 6.7e-18 65.1 9.8 1e-16 61.2 4.6 3.2 1 1 1 2 2 2 2 Insulin-induced protein (INSIG) Endosulfine PF04667.17 EDO18315.1 - 2.1e-32 111.1 0.3 2.9e-32 110.6 0.3 1.2 1 0 0 1 1 1 1 cAMP-regulated phosphoprotein/endosulfine conserved region Peptidase_M14 PF00246.24 EDO18316.1 - 3.7e-71 240.3 0.2 4.5e-71 240.0 0.2 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase DUF5136 PF17199.4 EDO18317.1 - 0.15 11.7 1.8 0.39 10.4 1.8 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF5136) Macoilin PF09726.9 EDO18317.1 - 1 7.8 4.8 1.3 7.4 4.8 1.1 1 0 0 1 1 1 0 Macoilin family MFA1_2 PF17317.2 EDO18319.1 - 1.7e-21 75.7 1.2 1.8e-21 75.6 1.2 1.0 1 0 0 1 1 1 1 Mating hormone A-factor 1&2 LOR PF04525.12 EDO18319.1 - 0.034 13.7 0.0 0.034 13.7 0.0 1.0 1 0 0 1 1 1 0 LURP-one-related MFA1_2 PF17317.2 EDO18320.1 - 1e-21 76.4 1.2 1.1e-21 76.3 1.2 1.0 1 0 0 1 1 1 1 Mating hormone A-factor 1&2 LOR PF04525.12 EDO18320.1 - 0.064 12.8 0.0 0.064 12.8 0.0 1.0 1 0 0 1 1 1 0 LURP-one-related MFA1_2 PF17317.2 EDO18321.1 - 1.7e-21 75.7 1.2 1.8e-21 75.6 1.2 1.0 1 0 0 1 1 1 1 Mating hormone A-factor 1&2 LOR PF04525.12 EDO18321.1 - 0.034 13.7 0.0 0.034 13.7 0.0 1.0 1 0 0 1 1 1 0 LURP-one-related UPRTase PF14681.6 EDO18322.1 - 9.1e-77 257.2 0.0 1.2e-76 256.8 0.0 1.0 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Pribosyltran PF00156.27 EDO18322.1 - 0.055 13.0 0.0 0.067 12.7 0.0 1.2 1 0 0 1 1 1 0 Phosphoribosyl transferase domain Flu_C_NS1 PF03506.13 EDO18322.1 - 0.18 11.8 0.1 0.3 11.0 0.1 1.3 1 0 0 1 1 1 0 Influenza C non-structural protein (NS1) Tom5 PF10642.9 EDO18323.1 - 1.3e-22 79.5 0.2 1.5e-22 79.4 0.2 1.0 1 0 0 1 1 1 1 Mitochondrial import receptor subunit or translocase Med26 PF08711.11 EDO18324.1 - 1.6e-12 47.3 0.2 1.4e-11 44.2 0.0 2.6 2 0 0 2 2 2 1 TFIIS helical bundle-like domain PP2C_C PF07830.13 EDO18324.1 - 0.19 12.2 3.8 1.6 9.3 0.0 3.0 2 1 0 2 2 2 0 Protein serine/threonine phosphatase 2C, C-terminal domain Phasin PF05597.11 EDO18324.1 - 2.8 8.0 8.2 0.19 11.7 2.5 2.1 2 0 0 2 2 2 0 Poly(hydroxyalcanoate) granule associated protein (phasin) Ribosom_S12_S23 PF00164.25 EDO18325.1 - 3.3e-51 171.7 0.3 4.2e-51 171.4 0.3 1.1 1 0 0 1 1 1 1 Ribosomal protein S12/S23 CNH PF00780.22 EDO18326.1 - 2.9e-05 23.8 0.7 0.016 14.8 0.0 2.3 2 0 0 2 2 2 2 CNH domain WD40 PF00400.32 EDO18326.1 - 0.22 12.5 1.2 2.2e+02 3.0 0.0 4.0 4 0 0 4 4 4 0 WD domain, G-beta repeat Acetyltransf_1 PF00583.25 EDO18327.1 - 4e-09 36.7 0.0 5.3e-09 36.3 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.10 EDO18327.1 - 2.1e-05 24.4 0.0 3.7e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_7 PF13508.7 EDO18327.1 - 0.00015 22.1 0.0 0.00022 21.6 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EDO18327.1 - 0.00015 21.7 0.0 0.00024 21.0 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 EDO18327.1 - 0.02 15.0 0.1 0.028 14.6 0.1 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain LSM14 PF12701.7 EDO18328.1 - 5.2e-25 87.3 0.0 9.5e-25 86.5 0.0 1.4 1 0 0 1 1 1 1 Scd6-like Sm domain FDF PF09532.10 EDO18328.1 - 1e-05 26.4 14.5 1e-05 26.4 14.5 3.6 2 1 0 2 2 2 1 FDF domain TFIIA PF03153.13 EDO18328.1 - 0.00061 19.9 18.7 0.00068 19.8 18.7 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit SpoIIIAH PF12685.7 EDO18328.1 - 0.0088 15.9 15.8 0.013 15.4 15.8 1.2 1 0 0 1 1 1 1 SpoIIIAH-like protein SM-ATX PF14438.6 EDO18328.1 - 0.092 12.9 0.0 0.21 11.7 0.0 1.7 1 0 0 1 1 1 0 Ataxin 2 SM domain PRP38_assoc PF12871.7 EDO18328.1 - 2.8 8.6 13.1 0.82 10.3 2.3 2.3 2 0 0 2 2 2 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term CDC45 PF02724.14 EDO18328.1 - 3.3 5.9 12.1 4.4 5.5 12.1 1.1 1 0 0 1 1 1 0 CDC45-like protein SelP_N PF04592.14 EDO18328.1 - 3.3 7.0 23.2 1 8.7 20.5 1.5 1 1 1 2 2 2 0 Selenoprotein P, N terminal region PAT1 PF09770.9 EDO18328.1 - 4.4 5.4 22.2 5.4 5.2 22.2 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Neur_chan_memb PF02932.16 EDO18328.1 - 5.9 6.9 10.2 8.1 6.4 10.2 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Aldo_ket_red PF00248.21 EDO18329.1 - 1.6e-48 165.4 0.0 1.9e-48 165.2 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family MTS PF05175.14 EDO18329.1 - 0.14 11.6 0.0 0.23 11.0 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain DUF4344 PF14247.6 EDO18330.1 - 0.052 13.2 0.1 0.094 12.4 0.1 1.3 1 0 0 1 1 1 0 Putative metallopeptidase TruD PF01142.18 EDO18331.1 - 7.3e-74 249.1 1.4 1.7e-68 231.4 0.1 3.2 2 1 0 2 2 2 2 tRNA pseudouridine synthase D (TruD) NifW PF03206.14 EDO18331.1 - 0.2 12.2 1.7 0.89 10.1 0.5 2.5 2 0 0 2 2 2 0 Nitrogen fixation protein NifW MOZ_SAS PF01853.18 EDO18332.1 - 8.7e-82 273.1 0.1 1.4e-81 272.5 0.1 1.3 1 0 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 EDO18332.1 - 1.4e-21 75.8 0.3 3.5e-21 74.5 0.3 1.7 1 0 0 1 1 1 1 MYST family zinc finger domain Tudor-knot PF11717.8 EDO18332.1 - 2.4e-21 75.4 0.1 4.8e-21 74.4 0.1 1.5 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Acetyltransf_1 PF00583.25 EDO18332.1 - 0.00082 19.6 0.0 0.0082 16.4 0.0 2.3 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EDO18332.1 - 0.0021 18.4 0.0 0.005 17.2 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain PTPA PF03095.15 EDO18333.1 - 5.8e-115 383.9 1.7 6.7e-115 383.7 1.7 1.0 1 0 0 1 1 1 1 Phosphotyrosyl phosphate activator (PTPA) protein F_actin_bind PF08919.10 EDO18333.1 - 0.16 12.1 0.5 0.36 10.9 0.1 1.7 2 0 0 2 2 2 0 F-actin binding DAGAT PF03982.13 EDO18334.1 - 5.5e-76 255.3 2.5 2.2e-68 230.4 0.1 2.1 2 0 0 2 2 2 2 Diacylglycerol acyltransferase PqiA PF04403.13 EDO18334.1 - 0.023 14.6 0.7 0.045 13.6 0.7 1.4 1 0 0 1 1 1 0 Paraquat-inducible protein A Asp PF00026.23 EDO18335.1 - 8.3e-107 357.2 0.3 1e-106 356.9 0.3 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EDO18335.1 - 8.5e-14 52.2 0.5 3.6e-12 46.9 0.5 2.4 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal gag-asp_proteas PF13975.6 EDO18335.1 - 0.014 16.0 0.0 1.2 9.8 0.0 2.5 2 0 0 2 2 2 0 gag-polyprotein putative aspartyl protease Kinesin PF00225.23 EDO18336.1 - 1.1e-103 346.7 1.3 2.1e-103 345.8 1.3 1.5 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EDO18336.1 - 6.1e-23 81.4 0.1 6.1e-23 81.4 0.1 2.5 3 0 0 3 3 3 1 Microtubule binding FlgN PF05130.12 EDO18336.1 - 4.1 7.9 11.7 0.17 12.4 0.4 3.3 2 1 1 3 3 3 0 FlgN protein Methyltransf_15 PF09445.10 EDO18337.1 - 7.7e-61 204.5 0.0 1.1e-60 204.0 0.0 1.2 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_25 PF13649.6 EDO18337.1 - 0.00036 21.2 0.0 0.00073 20.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDO18337.1 - 0.0035 17.2 0.0 0.0073 16.1 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain MethyltransfD12 PF02086.15 EDO18337.1 - 0.0044 16.7 0.1 0.0044 16.7 0.1 2.1 3 0 0 3 3 3 1 D12 class N6 adenine-specific DNA methyltransferase UPF0020 PF01170.18 EDO18337.1 - 0.071 12.8 0.0 0.85 9.3 0.0 2.2 1 1 0 1 1 1 0 Putative RNA methylase family UPF0020 Methyltransf_23 PF13489.6 EDO18337.1 - 0.072 12.9 0.0 0.18 11.6 0.0 1.7 1 1 0 1 1 1 0 Methyltransferase domain Pet20 PF08692.10 EDO18338.1 - 1.1e-15 58.5 8.5 6.6e-07 30.1 0.1 3.5 3 1 1 4 4 4 2 Mitochondrial protein Pet20 SPAR_C PF11881.8 EDO18338.1 - 0.016 15.1 1.1 0.016 15.1 1.1 2.0 2 0 0 2 2 2 0 C-terminal domain of SPAR protein STIMATE PF12400.8 EDO18339.1 - 3.6e-43 147.1 6.2 3.6e-43 147.1 6.2 1.8 2 0 0 2 2 2 1 STIMATE family DUF2208 PF09973.9 EDO18339.1 - 0.03 13.9 0.6 0.043 13.4 0.6 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2208) TRI5 PF06330.11 EDO18339.1 - 0.037 12.9 0.1 0.056 12.3 0.1 1.2 1 0 0 1 1 1 0 Trichodiene synthase (TRI5) YbbR PF07949.12 EDO18340.1 - 0.084 13.2 2.4 0.67 10.3 2.1 2.4 1 1 0 1 1 1 0 YbbR-like protein HATPase_c_3 PF13589.6 EDO18341.1 - 9.6e-12 44.9 0.1 2.3e-11 43.6 0.1 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 EDO18341.1 - 9.1e-07 29.4 0.1 2e-06 28.3 0.1 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase MutL_C PF08676.11 EDO18341.1 - 0.0017 18.1 0.0 0.011 15.5 0.0 2.2 2 0 0 2 2 2 1 MutL C terminal dimerisation domain DNA_mis_repair PF01119.19 EDO18341.1 - 0.034 13.8 0.3 0.088 12.5 0.3 1.8 1 1 0 1 1 1 0 DNA mismatch repair protein, C-terminal domain ANAPC5 PF12862.7 EDO18342.1 - 3.4e-28 97.6 1.5 3.4e-28 97.6 1.5 3.4 4 1 0 4 4 4 1 Anaphase-promoting complex subunit 5 CLP1_P PF16575.5 EDO18343.1 - 1.1e-28 100.3 0.0 1.7e-28 99.7 0.0 1.3 1 0 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop Clp1 PF06807.14 EDO18343.1 - 2.7e-25 89.1 0.0 4.7e-25 88.3 0.0 1.4 1 0 0 1 1 1 1 Pre-mRNA cleavage complex II protein Clp1 CLP1_N PF16573.5 EDO18343.1 - 2.8e-23 81.9 0.2 5.4e-23 81.0 0.2 1.5 1 0 0 1 1 1 1 N-terminal beta-sandwich domain of polyadenylation factor PduV-EutP PF10662.9 EDO18343.1 - 0.0008 19.2 0.0 0.0028 17.4 0.0 1.9 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation MMR_HSR1 PF01926.23 EDO18343.1 - 0.0012 19.0 0.1 0.0091 16.1 0.1 2.2 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_7 PF12775.7 EDO18343.1 - 0.011 15.2 0.0 0.02 14.4 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region Roc PF08477.13 EDO18343.1 - 0.039 14.2 0.0 0.13 12.4 0.0 1.9 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_24 PF13479.6 EDO18343.1 - 0.054 13.2 0.1 0.12 12.1 0.0 1.6 2 0 0 2 2 2 0 AAA domain ATP-synt_ab PF00006.25 EDO18343.1 - 0.19 11.3 0.1 1.1 8.8 0.0 1.9 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain Rhodanese PF00581.20 EDO18344.1 - 1.7e-14 54.2 0.0 1e-06 29.2 0.0 2.2 2 0 0 2 2 2 2 Rhodanese-like domain Atg29_N PF18388.1 EDO18345.1 - 3e-17 62.2 1.6 3.4e-16 58.8 0.2 2.6 2 0 0 2 2 2 1 Atg29 N-terminal domain DUF4640 PF15480.6 EDO18345.1 - 0.0008 19.2 7.1 0.01 15.6 6.2 2.4 1 1 1 2 2 2 1 Domain of unknown function (DUF4640) DNA_pol_B PF00136.21 EDO18346.1 - 1.9e-105 353.2 1.2 1.9e-105 353.2 1.2 2.3 2 0 0 2 2 2 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 EDO18346.1 - 9.7e-17 61.1 5.7 4.8e-08 32.5 0.3 2.7 2 0 0 2 2 2 2 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.6 EDO18346.1 - 1.5e-11 44.6 10.5 4.5e-11 43.1 10.5 1.9 1 0 0 1 1 1 1 C4-type zinc-finger of DNA polymerase delta RRM_9 PF18444.1 EDO18347.1 - 6.6e-30 102.8 0.2 1.3e-29 101.8 0.2 1.5 1 0 0 1 1 1 1 RNA recognition motif TAP_C PF03943.13 EDO18347.1 - 9.2e-13 47.6 0.1 2.8e-12 46.1 0.1 1.9 1 0 0 1 1 1 1 TAP C-terminal domain LRR_9 PF14580.6 EDO18347.1 - 8.1e-09 35.2 2.2 2.5e-08 33.6 2.2 1.7 1 1 1 2 2 2 1 Leucine-rich repeat LRR_4 PF12799.7 EDO18347.1 - 3.8e-05 24.0 16.7 0.00077 19.8 4.9 3.1 1 1 1 2 2 2 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EDO18347.1 - 0.019 14.7 2.9 0.019 14.7 2.9 2.2 2 0 0 2 2 2 0 Leucine rich repeat NTF2 PF02136.20 EDO18347.1 - 0.028 15.0 1.6 0.52 10.9 2.0 2.8 2 1 0 2 2 2 0 Nuclear transport factor 2 (NTF2) domain Hexose_dehydrat PF03559.14 EDO18347.1 - 0.11 11.8 0.0 0.22 10.9 0.0 1.4 1 0 0 1 1 1 0 NDP-hexose 2,3-dehydratase Peptidase_S24 PF00717.23 EDO18348.1 - 1e-08 35.0 0.1 4.3e-08 33.0 0.1 2.0 1 1 0 1 1 1 1 Peptidase S24-like Peptidase_S26 PF10502.9 EDO18348.1 - 0.00058 19.7 0.0 0.0024 17.6 0.0 1.8 1 1 1 2 2 2 1 Signal peptidase, peptidase S26 Rhodanese PF00581.20 EDO18349.1 - 1.8e-10 41.3 0.2 1.1e-09 38.8 0.0 2.4 2 0 0 2 2 2 1 Rhodanese-like domain Mucin PF01456.17 EDO18349.1 - 0.6 10.1 3.9 0.17 11.9 0.4 1.8 2 0 0 2 2 2 0 Mucin-like glycoprotein zf-C2H2 PF00096.26 EDO18350.1 - 2.3e-13 49.8 13.6 1.8e-06 28.1 3.4 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EDO18350.1 - 2.7e-09 37.1 12.4 9e-05 23.0 2.1 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EDO18350.1 - 1.5e-07 31.5 19.4 5.6e-07 29.7 5.0 3.3 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_jaz PF12171.8 EDO18350.1 - 1.6e-06 28.3 11.7 0.00034 20.8 4.7 2.5 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-BED PF02892.15 EDO18350.1 - 3.9e-06 26.8 5.3 0.0056 16.7 0.5 2.8 2 0 0 2 2 2 2 BED zinc finger zf-C2H2_6 PF13912.6 EDO18350.1 - 0.0018 18.2 4.5 0.0018 18.2 4.5 2.4 2 0 0 2 2 2 1 C2H2-type zinc finger zf-met PF12874.7 EDO18350.1 - 0.0044 17.4 6.0 0.42 11.1 1.5 2.6 2 0 0 2 2 2 2 Zinc-finger of C2H2 type AD PF09793.9 EDO18350.1 - 0.011 15.9 1.4 0.021 14.9 1.4 1.5 1 0 0 1 1 1 0 Anticodon-binding domain zf-C2HE PF16278.5 EDO18350.1 - 0.015 15.7 9.8 0.77 10.3 0.8 2.9 1 1 1 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger zf-H2C2_5 PF13909.6 EDO18350.1 - 0.03 14.1 13.3 0.11 12.3 4.0 2.7 2 0 0 2 2 2 0 C2H2-type zinc-finger domain GAGA PF09237.11 EDO18350.1 - 0.039 13.8 2.3 0.49 10.3 0.5 2.4 1 1 1 2 2 2 0 GAGA factor zf-C2H2_2 PF12756.7 EDO18350.1 - 0.054 13.8 9.0 1.5 9.2 1.6 3.1 2 1 1 3 3 3 0 C2H2 type zinc-finger (2 copies) zf-Di19 PF05605.12 EDO18350.1 - 0.11 12.8 3.7 0.22 11.8 3.7 1.5 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding PyrI_C PF02748.15 EDO18350.1 - 0.25 11.3 3.2 1 9.3 3.2 2.1 1 1 1 2 2 2 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-AN1 PF01428.16 EDO18350.1 - 0.26 11.5 3.4 11 6.3 0.4 2.3 2 0 0 2 2 2 0 AN1-like Zinc finger zf-C2H2_8 PF15909.5 EDO18350.1 - 0.31 11.4 4.7 3.1 8.2 1.8 2.7 2 0 0 2 2 2 0 C2H2-type zinc ribbon DUF629 PF04780.12 EDO18350.1 - 3 6.3 10.9 2.5 6.5 0.6 3.4 2 1 1 3 3 3 0 Protein of unknown function (DUF629) zf-LYAR PF08790.11 EDO18350.1 - 3.1 7.8 4.8 3.7 7.5 0.3 2.7 2 0 0 2 2 2 0 LYAR-type C2HC zinc finger LPAM_1 PF08139.12 EDO18351.1 - 0.16 12.6 0.9 0.23 12.0 0.9 1.3 1 0 0 1 1 1 0 Prokaryotic membrane lipoprotein lipid attachment site Tcp10_C PF07202.13 EDO18351.1 - 0.24 11.4 3.8 0.46 10.4 3.8 1.5 1 0 0 1 1 1 0 T-complex protein 10 C-terminus SOG2 PF10428.9 EDO18351.1 - 0.94 8.6 20.9 1.4 8.0 20.9 1.3 1 0 0 1 1 1 0 RAM signalling pathway protein MIIP PF15734.5 EDO18351.1 - 5 6.5 15.6 6.8 6.1 15.6 1.3 1 0 0 1 1 1 0 Migration and invasion-inhibitory PAT1 PF09770.9 EDO18351.1 - 8.6 4.5 41.6 11 4.1 41.6 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 SOBP PF15279.6 EDO18351.1 - 9.7 6.7 24.4 15 6.1 24.4 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein Aldo_ket_red PF00248.21 EDO18352.1 - 1.7e-60 204.8 0.0 2.1e-60 204.4 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family NDK PF00334.19 EDO18353.1 - 5.3e-55 185.1 0.0 6e-55 184.9 0.0 1.0 1 0 0 1 1 1 1 Nucleoside diphosphate kinase DUF4588 PF15251.6 EDO18354.1 - 4.5e-09 36.5 0.4 1.8e-08 34.5 0.4 1.9 1 1 0 1 1 1 1 Domain of unknown function (DUF4588) 6PF2K PF01591.18 EDO18354.1 - 0.0001 21.7 1.5 0.00012 21.5 0.7 1.5 1 1 0 1 1 1 1 6-phosphofructo-2-kinase SUR7 PF06687.12 EDO18355.1 - 1e-37 129.8 9.8 1.3e-37 129.5 9.8 1.1 1 0 0 1 1 1 1 SUR7/PalI family Gsf2 PF11055.8 EDO18356.1 - 1.3e-162 540.8 0.1 1.6e-162 540.6 0.1 1.0 1 0 0 1 1 1 1 Glucose signalling factor 2 Tmemb_9 PF05434.11 EDO18357.1 - 0.85 9.5 4.2 0.33 10.8 0.6 2.2 2 0 0 2 2 2 0 TMEM9 MukF_C PF17193.4 EDO18358.1 - 0.015 15.5 0.1 1.1 9.4 0.0 2.6 2 0 0 2 2 2 0 MukF C-terminal domain Herpes_UL92 PF03048.14 EDO18358.1 - 0.094 12.5 3.4 7 6.4 1.4 2.7 2 0 0 2 2 2 0 UL92 family LRR_6 PF13516.6 EDO18359.1 - 0.006 16.6 9.5 2.4 8.4 0.0 6.2 6 0 0 6 6 6 2 Leucine Rich repeat LRR_4 PF12799.7 EDO18359.1 - 0.078 13.4 0.2 0.078 13.4 0.2 6.9 6 4 1 8 8 8 0 Leucine Rich repeats (2 copies) LAP1C PF05609.12 EDO18359.1 - 0.11 11.5 9.7 0.15 11.1 9.7 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) FRG2 PF15315.6 EDO18359.1 - 0.26 11.5 14.5 0.44 10.7 14.5 1.4 1 0 0 1 1 1 0 Facioscapulohumeral muscular dystrophy candidate 2 DUF4404 PF14357.6 EDO18359.1 - 8.2 7.1 8.0 8.4 7.1 0.2 3.1 2 1 1 3 3 3 0 Domain of unknown function (DUF4404) hDGE_amylase PF14701.6 EDO18360.1 - 3.7e-176 586.5 0.5 7e-176 585.6 0.5 1.5 1 0 0 1 1 1 1 Glycogen debranching enzyme, glucanotransferase domain GDE_C PF06202.14 EDO18360.1 - 2.6e-130 434.8 0.0 3.9e-130 434.2 0.0 1.3 1 0 0 1 1 1 1 Amylo-alpha-1,6-glucosidase hGDE_central PF14702.6 EDO18360.1 - 7.1e-81 271.6 0.1 1.9e-80 270.2 0.0 1.8 2 0 0 2 2 2 1 Central domain of human glycogen debranching enzyme hGDE_N PF14699.6 EDO18360.1 - 5.5e-24 84.1 0.2 1.1e-22 79.9 0.1 2.6 2 0 0 2 2 2 1 N-terminal domain from the human glycogen debranching enzyme Alpha-amylase PF00128.24 EDO18360.1 - 0.00035 20.2 0.1 0.0011 18.6 0.1 1.8 2 0 0 2 2 2 1 Alpha amylase, catalytic domain Glycos_transf_2 PF00535.26 EDO18361.1 - 7.1e-31 107.3 0.0 1e-30 106.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 EDO18361.1 - 2.2e-06 27.7 0.0 3e-06 27.3 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 EDO18361.1 - 0.0052 16.3 0.0 0.0074 15.8 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 LSM PF01423.22 EDO18362.1 - 5e-19 67.7 0.2 5.7e-19 67.6 0.2 1.1 1 0 0 1 1 1 1 LSM domain Sec23_trunk PF04811.15 EDO18363.1 - 1.2e-73 247.7 0.0 1.7e-73 247.2 0.0 1.2 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_BS PF08033.12 EDO18363.1 - 1.3e-29 102.8 0.7 3.5e-29 101.4 0.7 1.8 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain Sec23_helical PF04815.15 EDO18363.1 - 1.1e-25 89.4 0.0 2.4e-25 88.3 0.0 1.6 1 0 0 1 1 1 1 Sec23/Sec24 helical domain zf-Sec23_Sec24 PF04810.15 EDO18363.1 - 1e-12 47.8 8.8 2.3e-12 46.7 8.8 1.6 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 EDO18363.1 - 6.4e-11 42.0 0.0 1.2e-10 41.1 0.0 1.5 1 0 0 1 1 1 1 Gelsolin repeat Vps36-NZF-N PF16988.5 EDO18363.1 - 0.00064 19.1 2.2 0.0019 17.5 2.2 1.7 1 0 0 1 1 1 1 Vacuolar protein sorting 36 NZF-N zinc-finger domain tRNA-synt_1g PF09334.11 EDO18363.1 - 0.11 11.2 0.2 0.25 10.1 0.1 1.5 2 0 0 2 2 2 0 tRNA synthetases class I (M) zf-MIZ PF02891.20 EDO18363.1 - 0.12 12.1 1.5 0.27 11.0 1.5 1.6 1 0 0 1 1 1 0 MIZ/SP-RING zinc finger HDA2-3 PF11496.8 EDO18364.1 - 2.8e-92 309.0 3.6 2.8e-92 309.0 3.6 3.1 3 1 0 3 3 3 1 Class II histone deacetylase complex subunits 2 and 3 DUF812 PF05667.11 EDO18364.1 - 1.9e-05 23.8 23.5 2.6e-05 23.3 23.5 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF812) GvpL_GvpF PF06386.11 EDO18364.1 - 0.79 9.6 6.6 1.4 8.8 6.6 1.4 1 0 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF DUF948 PF06103.11 EDO18364.1 - 1.9 8.8 4.2 2.7 8.3 0.7 2.8 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) DUF724 PF05266.14 EDO18364.1 - 3.2 7.6 29.7 1.3 8.8 11.3 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF724) Baculo_PEP_C PF04513.12 EDO18364.1 - 5.7 7.0 13.2 0.14 12.2 4.2 2.7 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus PspA_IM30 PF04012.12 EDO18364.1 - 8.6 5.9 20.4 12 5.4 11.0 2.5 1 1 2 3 3 3 0 PspA/IM30 family WD40 PF00400.32 EDO18365.1 - 5.1e-14 52.5 9.8 3e-08 34.2 2.3 3.2 3 0 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDO18365.1 - 0.075 13.3 0.3 0.17 12.2 0.3 1.6 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EDO18366.1 - 5.5e-21 74.5 10.0 4.1e-05 24.2 0.2 5.3 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDO18366.1 - 7.2e-12 45.4 0.2 0.0037 17.5 0.0 4.4 2 1 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EDO18366.1 - 0.00035 20.5 0.1 0.0056 16.6 0.0 2.3 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 EDO18366.1 - 0.015 14.7 0.1 4.9 6.4 0.0 2.4 2 0 0 2 2 2 0 WD40-like domain Prenyltrans PF00432.21 EDO18367.1 - 2.7e-61 203.0 4.3 4.7e-13 48.6 0.0 6.1 6 0 0 6 6 6 5 Prenyltransferase and squalene oxidase repeat SQHop_cyclase_C PF13243.6 EDO18367.1 - 9e-06 25.0 0.0 0.00019 20.7 0.0 2.5 2 1 1 3 3 3 1 Squalene-hopene cyclase C-terminal domain SQHop_cyclase_N PF13249.6 EDO18367.1 - 0.0023 17.1 0.0 5.3 6.0 0.0 3.9 1 1 2 5 5 5 2 Squalene-hopene cyclase N-terminal domain DNA_pol_E_B PF04042.16 EDO18368.1 - 4.9e-55 186.1 0.3 8.5e-55 185.4 0.3 1.4 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B NBP1 PF08537.10 EDO18369.1 - 7.6e-133 443.1 17.6 8.6e-133 442.9 17.6 1.0 1 0 0 1 1 1 1 Fungal Nap binding protein NBP1 SOGA PF11365.8 EDO18369.1 - 0.7 11.1 7.2 4.5 8.5 3.8 3.0 1 1 1 2 2 2 0 Protein SOGA AAA PF00004.29 EDO18370.1 - 8e-44 149.3 0.0 1.4e-43 148.4 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.10 EDO18370.1 - 4.3e-31 106.7 0.2 1.9e-30 104.7 0.3 2.1 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain MIT PF04212.18 EDO18370.1 - 2.6e-23 81.9 2.4 6.8e-23 80.5 2.4 1.8 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain AAA_lid_3 PF17862.1 EDO18370.1 - 1.3e-06 28.1 0.1 2.6e-05 23.9 0.0 2.9 3 0 0 3 3 2 1 AAA+ lid domain AAA_16 PF13191.6 EDO18370.1 - 5.4e-06 26.9 0.2 7.6e-05 23.1 0.1 2.6 2 1 0 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 EDO18370.1 - 6.3e-06 26.0 0.0 1.1e-05 25.2 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EDO18370.1 - 2e-05 24.9 0.1 0.012 15.9 0.0 2.6 1 1 1 2 2 2 1 AAA domain AAA_5 PF07728.14 EDO18370.1 - 2.1e-05 24.5 0.0 9.4e-05 22.4 0.0 2.2 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) DUF815 PF05673.13 EDO18370.1 - 3.5e-05 23.1 0.0 0.00066 18.9 0.0 2.5 1 1 1 2 2 2 1 Protein of unknown function (DUF815) IstB_IS21 PF01695.17 EDO18370.1 - 6.7e-05 22.7 0.0 0.00015 21.5 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_14 PF13173.6 EDO18370.1 - 0.0001 22.4 0.0 0.00036 20.6 0.0 1.9 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 EDO18370.1 - 0.00011 22.6 0.3 0.009 16.4 0.0 3.2 4 0 0 4 4 3 1 RNA helicase AAA_2 PF07724.14 EDO18370.1 - 0.00026 21.2 0.1 0.0017 18.5 0.0 2.2 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) TIP49 PF06068.13 EDO18370.1 - 0.00026 20.3 0.0 0.00048 19.4 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_18 PF13238.6 EDO18370.1 - 0.00055 20.5 0.4 0.002 18.7 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EDO18370.1 - 0.0013 18.9 0.1 0.005 17.0 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.6 EDO18370.1 - 0.0019 18.6 0.3 0.03 14.8 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.6 EDO18370.1 - 0.0033 17.2 0.6 0.0094 15.7 0.0 2.0 3 0 0 3 3 2 1 AAA domain AAA_25 PF13481.6 EDO18370.1 - 0.015 14.8 0.1 0.41 10.2 0.1 2.3 1 1 0 2 2 2 0 AAA domain AAA_7 PF12775.7 EDO18370.1 - 0.033 13.7 0.0 0.091 12.3 0.0 1.7 1 1 0 1 1 1 0 P-loop containing dynein motor region ATPase PF06745.13 EDO18370.1 - 0.033 13.5 0.1 5.4 6.3 0.0 2.3 1 1 1 2 2 2 0 KaiC Torsin PF06309.11 EDO18370.1 - 0.035 14.2 0.0 0.071 13.2 0.0 1.5 1 0 0 1 1 1 0 Torsin Mg_chelatase PF01078.21 EDO18370.1 - 0.037 13.4 0.0 0.082 12.3 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Zeta_toxin PF06414.12 EDO18370.1 - 0.038 13.3 0.2 1.1 8.5 0.1 2.8 1 1 2 3 3 3 0 Zeta toxin NACHT PF05729.12 EDO18370.1 - 0.061 13.2 0.0 0.69 9.8 0.0 2.2 1 1 1 2 2 2 0 NACHT domain PhoH PF02562.16 EDO18370.1 - 0.074 12.5 0.1 0.16 11.4 0.1 1.5 1 0 0 1 1 1 0 PhoH-like protein Parvo_NS1 PF01057.17 EDO18370.1 - 0.079 12.0 0.0 0.17 11.0 0.0 1.5 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 ABC_tran PF00005.27 EDO18370.1 - 0.083 13.4 0.4 1.2 9.6 0.0 2.6 2 1 0 2 2 2 0 ABC transporter Sigma54_activat PF00158.26 EDO18370.1 - 0.089 12.5 0.0 0.31 10.7 0.0 2.0 1 1 0 1 1 1 0 Sigma-54 interaction domain AAA_11 PF13086.6 EDO18370.1 - 0.18 11.6 1.7 3.8 7.2 0.0 2.3 2 0 0 2 2 2 0 AAA domain ATPase_2 PF01637.18 EDO18370.1 - 0.2 11.5 1.9 2.3 8.1 0.0 2.9 2 1 1 3 3 3 0 ATPase domain predominantly from Archaea Putative_PNPOx PF01243.20 EDO18371.1 - 1.6e-17 63.4 0.0 1e-16 60.9 0.0 2.1 3 0 0 3 3 3 1 Pyridoxamine 5'-phosphate oxidase Pyrid_ox_like PF16242.5 EDO18371.1 - 0.058 13.0 0.1 0.38 10.3 0.0 2.1 2 0 0 2 2 2 0 Pyridoxamine 5'-phosphate oxidase like Pyridox_ox_2 PF12900.7 EDO18371.1 - 0.058 13.4 0.0 2.8 7.9 0.0 2.2 2 0 0 2 2 2 0 Pyridoxamine 5'-phosphate oxidase ABC_membrane PF00664.23 EDO18373.1 - 0.012 15.2 0.5 0.015 15.0 0.5 1.0 1 0 0 1 1 1 0 ABC transporter transmembrane region DUF2206 PF09971.9 EDO18373.1 - 0.079 11.7 0.0 0.083 11.6 0.0 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2206) ANAPC4_WD40 PF12894.7 EDO18374.1 - 2.8e-06 27.5 0.9 0.056 13.7 0.1 3.8 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EDO18374.1 - 0.001 19.9 0.7 0.72 10.8 0.0 4.4 4 0 0 4 4 4 1 WD domain, G-beta repeat PQQ_3 PF13570.6 EDO18374.1 - 0.076 13.5 0.1 48 4.6 0.0 3.7 4 0 0 4 4 4 0 PQQ-like domain PQQ PF01011.21 EDO18374.1 - 0.12 12.4 1.5 30 4.8 0.4 3.6 3 0 0 3 3 3 0 PQQ enzyme repeat Secretin_N_2 PF07655.13 EDO18374.1 - 7.6 7.2 14.0 9.8 6.8 11.3 2.7 2 0 0 2 2 2 0 Secretin N-terminal domain Ribosomal_S14 PF00253.21 EDO18375.1 - 8.2e-20 70.3 0.2 1.3e-19 69.7 0.2 1.3 1 0 0 1 1 1 1 Ribosomal protein S14p/S29e Ras PF00071.22 EDO18376.1 - 1.3e-53 180.9 0.0 1.5e-53 180.7 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EDO18376.1 - 5.4e-21 75.0 0.0 8.7e-21 74.4 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EDO18376.1 - 1.2e-07 31.4 0.0 1.7e-07 30.8 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EDO18376.1 - 0.00015 21.3 0.1 0.00041 19.9 0.0 1.6 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EDO18376.1 - 0.017 14.5 0.0 0.022 14.1 0.0 1.3 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region Ras PF00071.22 EDO18377.1 - 2e-55 186.8 0.0 2.4e-55 186.6 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EDO18377.1 - 3.1e-21 75.8 0.0 5.3e-21 75.1 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EDO18377.1 - 6e-07 29.1 0.0 8.1e-07 28.6 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EDO18377.1 - 0.073 12.4 0.0 0.096 12.0 0.0 1.3 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region Fmp27 PF10344.9 EDO18378.1 - 2.4e-206 687.7 40.9 4.3e-206 686.9 40.9 1.4 1 0 0 1 1 1 1 Mitochondrial protein from FMP27 Fmp27_WPPW PF10359.9 EDO18378.1 - 5.4e-108 361.9 11.0 1e-107 361.0 11.0 1.5 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain Apt1 PF10351.9 EDO18378.1 - 4.5e-74 250.0 17.2 2.5e-53 181.7 9.9 3.2 2 1 1 3 3 3 2 Golgi-body localisation protein domain Fmp27_GFWDK PF10347.9 EDO18378.1 - 5.9e-60 201.9 1.9 3.9e-59 199.2 0.2 2.6 2 0 0 2 2 2 1 RNA pol II promoter Fmp27 protein domain DUF2405 PF10293.9 EDO18378.1 - 5.7e-52 175.7 1.8 5.7e-52 175.7 1.8 3.3 3 0 0 3 3 3 1 Domain of unknown function (DUF2405) Fmp27_SW PF10305.9 EDO18378.1 - 8.9e-31 106.7 0.3 5.5e-30 104.1 0.0 2.7 2 0 0 2 2 2 1 RNA pol II promoter Fmp27 protein domain Ribosomal_S6 PF01250.17 EDO18378.1 - 2.2 8.6 4.3 7.7 6.9 0.1 3.0 3 0 0 3 3 3 0 Ribosomal protein S6 RRM_1 PF00076.22 EDO18379.1 - 1.6e-06 27.8 0.0 2.9e-06 27.0 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Pkinase PF00069.25 EDO18380.1 - 3e-74 249.7 0.0 6e-74 248.7 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO18380.1 - 2.5e-28 99.1 0.1 4.4e-27 95.0 0.1 2.3 1 1 0 1 1 1 1 Protein tyrosine kinase VitD-bind_III PF09164.10 EDO18380.1 - 0.039 13.9 0.1 0.16 12.0 0.1 2.1 1 0 0 1 1 1 0 Vitamin D binding protein, domain III RGS PF00615.19 EDO18381.1 - 6.7e-17 61.8 0.3 4.1e-11 43.2 0.2 2.6 2 0 0 2 2 2 2 Regulator of G protein signaling domain DEP PF00610.21 EDO18381.1 - 8.6e-12 44.9 0.0 2.9e-11 43.3 0.0 2.0 2 0 0 2 2 2 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) eIF2_C PF09173.11 EDO18382.1 - 1.7e-34 117.9 0.5 4.2e-34 116.7 0.5 1.7 1 0 0 1 1 1 1 Initiation factor eIF2 gamma, C terminal GTP_EFTU PF00009.27 EDO18382.1 - 3.7e-23 82.1 0.3 3.5e-22 78.9 0.3 2.2 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 EDO18382.1 - 1.7e-08 34.8 0.3 5.7e-08 33.0 0.3 2.0 1 0 0 1 1 1 1 Elongation factor Tu domain 2 RsgA_GTPase PF03193.16 EDO18382.1 - 0.00033 20.6 0.1 0.082 12.8 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 EDO18382.1 - 0.0027 17.8 0.0 0.0054 16.8 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase MMR_HSR1_Xtn PF16897.5 EDO18382.1 - 0.039 14.0 0.1 0.1 12.6 0.1 1.6 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain Carn_acyltransf PF00755.20 EDO18383.1 - 5.1e-117 392.0 0.2 9.4e-117 391.1 0.0 1.5 2 0 0 2 2 2 1 Choline/Carnitine o-acyltransferase Ribosomal_S7 PF00177.21 EDO18384.1 - 5.2e-37 126.8 1.9 8e-37 126.2 1.9 1.2 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e DUF5591 PF17884.1 EDO18384.1 - 0.007 16.2 0.0 0.011 15.6 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF5591) ATP-synt_ab PF00006.25 EDO18385.1 - 5.7e-62 209.1 0.0 8.3e-62 208.6 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 EDO18385.1 - 3.9e-22 78.6 1.5 3.9e-22 78.6 1.5 2.1 2 0 0 2 2 2 1 ATP synthase alpha/beta family, beta-barrel domain ATPase PF06745.13 EDO18385.1 - 0.0044 16.4 0.2 0.0074 15.6 0.2 1.4 1 0 0 1 1 1 1 KaiC NB-ARC PF00931.22 EDO18385.1 - 0.01 15.0 0.6 0.078 12.1 0.1 2.0 2 0 0 2 2 2 0 NB-ARC domain NACHT PF05729.12 EDO18385.1 - 0.034 14.1 0.2 0.12 12.3 0.0 1.9 2 0 0 2 2 2 0 NACHT domain RsgA_GTPase PF03193.16 EDO18385.1 - 0.041 13.8 0.0 0.099 12.5 0.0 1.6 1 0 0 1 1 1 0 RsgA GTPase T3SS_ATPase_C PF18269.1 EDO18385.1 - 0.045 13.6 0.7 0.3 11.0 0.7 2.2 1 1 0 1 1 1 0 T3SS EscN ATPase C-terminal domain AAA PF00004.29 EDO18385.1 - 0.075 13.5 0.1 0.77 10.2 0.0 2.4 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EDO18385.1 - 0.093 13.1 0.7 0.29 11.5 0.2 2.1 2 1 0 2 2 2 0 AAA ATPase domain RNA_helicase PF00910.22 EDO18385.1 - 0.13 12.6 0.0 0.27 11.6 0.0 1.5 1 0 0 1 1 1 0 RNA helicase AAA_19 PF13245.6 EDO18385.1 - 0.19 12.0 1.6 0.47 10.8 0.1 2.2 3 0 0 3 3 3 0 AAA domain TsaE PF02367.17 EDO18385.1 - 0.19 11.7 0.2 0.51 10.3 0.1 1.7 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Pox_A32 PF04665.12 EDO18385.1 - 0.25 10.8 0.1 0.5 9.8 0.1 1.4 1 0 0 1 1 1 0 Poxvirus A32 protein P5CR_dimer PF14748.6 EDO18386.1 - 6.1e-33 113.2 0.3 1.2e-32 112.2 0.3 1.5 1 0 0 1 1 1 1 Pyrroline-5-carboxylate reductase dimerisation F420_oxidored PF03807.17 EDO18386.1 - 1.4e-11 44.9 0.3 3.7e-11 43.5 0.3 1.8 1 1 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Med17 PF10156.9 EDO18387.1 - 5.2e-178 592.5 17.0 6.3e-178 592.2 17.0 1.1 1 0 0 1 1 1 1 Subunit 17 of Mediator complex PfkB PF00294.24 EDO18388.1 - 5.2e-72 242.7 1.6 6.4e-72 242.4 1.6 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Phos_pyr_kin PF08543.12 EDO18388.1 - 5.2e-05 22.8 0.0 8.5e-05 22.0 0.0 1.2 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase G-alpha PF00503.20 EDO18389.1 - 5.8e-101 338.2 10.1 5.8e-101 338.2 10.1 2.0 1 1 0 2 2 2 1 G-protein alpha subunit Arf PF00025.21 EDO18389.1 - 5.7e-13 48.7 4.8 1.2e-09 37.9 0.1 3.1 3 0 0 3 3 3 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EDO18389.1 - 0.00011 21.7 1.5 0.025 14.0 0.3 2.9 2 1 1 3 3 3 2 Gtr1/RagA G protein conserved region Roc PF08477.13 EDO18389.1 - 0.00017 21.8 4.9 0.56 10.4 0.0 3.7 3 0 0 3 3 3 2 Ras of Complex, Roc, domain of DAPkinase FtsK_SpoIIIE PF01580.18 EDO18389.1 - 0.006 16.0 0.1 0.014 14.8 0.1 1.5 1 0 0 1 1 1 1 FtsK/SpoIIIE family SMP_C2CD2L PF18696.1 EDO18389.1 - 0.082 12.7 0.0 0.54 10.1 0.0 2.2 2 0 0 2 2 2 0 Synaptotagmin-like, mitochondrial and lipid-binding domain Ras PF00071.22 EDO18389.1 - 0.15 11.7 3.3 19 4.8 0.0 3.6 3 1 0 3 3 3 0 Ras family SNAP PF14938.6 EDO18390.1 - 8e-110 366.7 10.8 9.1e-110 366.5 10.8 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP Foie-gras_1 PF11817.8 EDO18390.1 - 3.4e-05 23.6 0.1 5.8e-05 22.8 0.1 1.5 1 0 0 1 1 1 1 Foie gras liver health family 1 DUF2225 PF09986.9 EDO18390.1 - 0.00099 18.9 7.1 0.42 10.3 3.9 3.0 1 1 1 2 2 2 2 Uncharacterized protein conserved in bacteria (DUF2225) TPR_6 PF13174.6 EDO18390.1 - 0.0018 18.8 9.7 4.4 8.2 0.2 5.2 4 1 1 5 5 5 2 Tetratricopeptide repeat Spatacsin_C PF14649.6 EDO18390.1 - 0.15 11.1 6.7 0.19 10.8 2.9 2.4 1 1 0 2 2 2 0 Spatacsin C-terminus Yippee-Mis18 PF03226.14 EDO18391.1 - 3e-15 56.3 3.7 4e-15 55.9 3.7 1.2 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly DUF2757 PF10955.8 EDO18391.1 - 0.39 11.0 0.3 0.39 11.0 0.3 2.6 3 1 0 3 3 3 0 Protein of unknown function (DUF2757) Myotub-related PF06602.14 EDO18392.1 - 1.7e-138 461.4 6.1 2.2e-138 461.0 6.1 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain GRAM PF02893.20 EDO18392.1 - 5.2e-05 23.1 0.0 0.00019 21.3 0.0 2.0 1 0 0 1 1 1 1 GRAM domain Y_phosphatase3 PF13350.6 EDO18392.1 - 0.11 12.5 0.0 0.19 11.6 0.0 1.4 1 0 0 1 1 1 0 Tyrosine phosphatase family CMD PF02627.20 EDO18393.1 - 1.9e-06 27.8 0.0 4.8e-06 26.5 0.0 1.6 2 0 0 2 2 2 1 Carboxymuconolactone decarboxylase family EF-hand_4 PF12763.7 EDO18394.1 - 3e-34 117.1 3.5 5.7e-10 39.1 0.0 4.4 4 0 0 4 4 4 3 Cytoskeletal-regulatory complex EF hand UBA PF00627.31 EDO18394.1 - 1.3e-09 37.8 0.0 3.1e-09 36.6 0.0 1.7 1 0 0 1 1 1 1 UBA/TS-N domain EF-hand_1 PF00036.32 EDO18394.1 - 4.9e-08 32.0 0.2 0.0098 15.4 0.0 3.9 4 0 0 4 4 4 2 EF hand EF-hand_6 PF13405.6 EDO18394.1 - 3.6e-07 29.6 0.0 0.25 11.4 0.0 4.2 4 0 0 4 4 4 2 EF-hand domain EF-hand_7 PF13499.6 EDO18394.1 - 6.7e-06 26.5 1.3 0.24 11.9 0.0 4.7 4 0 0 4 4 4 1 EF-hand domain pair UBA_4 PF14555.6 EDO18394.1 - 0.033 14.0 0.0 0.08 12.8 0.0 1.7 1 0 0 1 1 1 0 UBA-like domain EF-hand_5 PF13202.6 EDO18394.1 - 0.035 13.6 0.0 4.7 6.9 0.0 2.8 2 0 0 2 2 2 0 EF hand CUE PF02845.16 EDO18394.1 - 0.044 13.5 0.1 0.67 9.7 0.0 2.7 2 0 0 2 2 2 0 CUE domain VanZ PF04892.12 EDO18395.1 - 1e-08 35.8 0.2 1.9e-08 35.0 0.2 1.4 1 1 0 1 1 1 1 VanZ like family Ribosomal_S7 PF00177.21 EDO18396.1 - 4e-36 123.9 0.1 7.1e-36 123.1 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e PPP4R2 PF09184.11 EDO18397.1 - 1.8e-66 224.7 15.4 1.8e-66 224.7 15.4 2.3 1 1 1 2 2 2 1 PPP4R2 Peptidase_M16_C PF05193.21 EDO18398.1 - 5.4e-20 72.2 0.1 1.2e-19 71.0 0.1 1.6 1 0 0 1 1 1 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 EDO18398.1 - 6.6e-16 58.6 0.8 1.2e-15 57.8 0.8 1.5 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Astro_capsid_p PF12226.8 EDO18399.1 - 6.9 5.7 12.5 9.2 5.3 12.5 1.2 1 0 0 1 1 1 0 Turkey astrovirus capsid protein Peptidase_M20 PF01546.28 EDO18400.1 - 4.7e-27 95.0 0.0 7.3e-27 94.4 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 EDO18400.1 - 5.7e-15 55.2 0.0 1.5e-14 53.8 0.0 1.7 2 0 0 2 2 2 1 Peptidase dimerisation domain VWA_N PF08399.11 EDO18400.1 - 0.12 12.8 0.0 0.28 11.7 0.0 1.6 1 0 0 1 1 1 0 VWA N-terminal Transp_cyt_pur PF02133.15 EDO18401.1 - 8.1e-131 436.8 24.0 9.7e-131 436.6 24.0 1.1 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Sod_Cu PF00080.20 EDO18402.1 - 3.7e-42 143.9 3.5 4.1e-42 143.7 3.5 1.0 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) CTP_synth_N PF06418.14 EDO18403.1 - 2.7e-125 417.0 0.9 3.5e-125 416.6 0.9 1.2 1 0 0 1 1 1 1 CTP synthase N-terminus GATase PF00117.28 EDO18403.1 - 3.3e-58 196.6 0.0 5.1e-58 196.0 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 EDO18403.1 - 0.0029 17.4 0.0 0.01 15.6 0.0 1.9 1 1 0 1 1 1 1 Peptidase C26 Scramblase PF03803.15 EDO18404.1 - 4.9e-69 232.0 0.1 1.1e-66 224.3 0.1 2.0 1 1 0 1 1 1 1 Scramblase SAC3_GANP PF03399.16 EDO18405.1 - 3.4e-24 85.7 12.6 2.5e-22 79.6 12.6 2.3 1 1 0 1 1 1 1 SAC3/GANP family CSN8_PSD8_EIF3K PF10075.9 EDO18405.1 - 2.3e-09 37.4 4.1 4.1e-09 36.6 2.3 2.1 2 0 0 2 2 2 1 CSN8/PSMD8/EIF3K family PCI PF01399.27 EDO18405.1 - 0.0002 21.9 1.2 0.0002 21.9 1.2 2.5 2 1 0 2 2 2 1 PCI domain Tho1_MOS11_C PF18592.1 EDO18405.1 - 0.01 15.6 0.1 0.027 14.3 0.1 1.7 1 0 0 1 1 1 0 Tho1/MOS11 C-terminal domain COX5A PF02284.16 EDO18405.1 - 0.45 10.6 6.2 0.12 12.4 0.4 2.9 4 0 0 4 4 4 0 Cytochrome c oxidase subunit Va PX PF00787.24 EDO18406.1 - 0.00021 21.3 1.3 0.00045 20.2 0.2 2.1 2 0 0 2 2 2 1 PX domain ZapA PF05164.13 EDO18406.1 - 0.049 14.1 0.0 0.12 12.9 0.0 1.6 1 0 0 1 1 1 0 Cell division protein ZapA Aldo_ket_red PF00248.21 EDO18407.1 - 7.1e-45 153.5 0.0 1.1e-42 146.3 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family DUF645 PF04875.12 EDO18407.1 - 0.066 13.3 0.0 0.12 12.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF645 DUF4817 PF16087.5 EDO18407.1 - 0.074 12.9 0.0 0.14 12.0 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain (DUF4817) Mito_carr PF00153.27 EDO18408.1 - 6.5e-71 234.3 8.1 9.9e-24 83.1 0.0 3.5 3 1 0 3 3 3 3 Mitochondrial carrier protein Ysc84 PF04366.12 EDO18408.1 - 0.0022 17.7 0.9 0.004 16.9 0.9 1.4 1 0 0 1 1 1 1 Las17-binding protein actin regulator PGM_PMM_I PF02878.16 EDO18410.1 - 6.3e-17 61.6 0.0 1.7e-09 37.5 0.0 2.6 1 1 1 2 2 2 2 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_IV PF00408.20 EDO18410.1 - 2.9e-11 43.4 0.1 9.3e-11 41.8 0.1 1.9 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain PGM_PMM_II PF02879.16 EDO18410.1 - 0.0029 18.2 0.0 0.014 16.0 0.0 2.2 1 1 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II Mitochondr_Som1 PF11093.8 EDO18411.1 - 2.4e-14 53.1 0.9 3.1e-14 52.7 0.9 1.2 1 0 0 1 1 1 1 Mitochondrial export protein Som1 Colipase-like PF15083.6 EDO18411.1 - 0.028 14.5 0.7 0.033 14.3 0.7 1.1 1 0 0 1 1 1 0 Colipase-like Lyase_1 PF00206.20 EDO18412.1 - 3e-116 388.2 0.1 3.8e-116 387.8 0.1 1.1 1 0 0 1 1 1 1 Lyase FumaraseC_C PF10415.9 EDO18412.1 - 1.8e-25 89.1 0.1 1.6e-24 86.1 0.0 2.3 2 0 0 2 2 2 1 Fumarase C C-terminus Peptidase_S8 PF00082.22 EDO18413.1 - 1.1e-31 110.2 7.4 1.1e-31 110.2 7.4 3.2 2 2 0 2 2 2 1 Subtilase family Inhibitor_I9 PF05922.16 EDO18413.1 - 3.3e-09 37.3 0.5 1.1e-08 35.6 0.5 2.0 1 0 0 1 1 1 1 Peptidase inhibitor I9 NFACT-C PF11923.8 EDO18413.1 - 0.05 13.5 0.5 0.26 11.2 0.4 2.2 2 0 0 2 2 2 0 NFACT protein C-terminal domain Collagen PF01391.18 EDO18413.1 - 0.14 11.9 17.5 21 5.0 17.5 2.6 1 1 0 1 1 1 0 Collagen triple helix repeat (20 copies) RRN3 PF05327.11 EDO18413.1 - 0.15 10.6 5.2 0.28 9.7 5.2 1.4 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Kinesin PF00225.23 EDO18414.1 - 5.3e-94 314.9 18.9 2.3e-61 207.6 8.1 3.8 4 1 0 4 4 4 2 Kinesin motor domain Microtub_bd PF16796.5 EDO18414.1 - 3.4e-21 75.7 0.0 3.4e-21 75.7 0.0 3.1 3 0 0 3 3 3 1 Microtubule binding DNA_ligase_A_M PF01068.21 EDO18415.1 - 2.3e-45 154.8 0.0 6e-45 153.4 0.0 1.8 1 0 0 1 1 1 1 ATP dependent DNA ligase domain BRCT_2 PF16589.5 EDO18415.1 - 1.3e-30 105.6 0.1 1e-16 61.1 0.0 2.8 2 0 0 2 2 2 2 BRCT domain, a BRCA1 C-terminus domain DNA_ligase_A_N PF04675.14 EDO18415.1 - 1.4e-26 93.8 0.1 2.6e-26 93.0 0.1 1.4 1 0 0 1 1 1 1 DNA ligase N terminus BRCT PF00533.26 EDO18415.1 - 6.5e-12 45.7 2.0 6.7e-05 23.2 0.0 3.3 2 1 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain RNA_ligase PF09414.10 EDO18415.1 - 3.2e-08 34.1 0.0 9e-08 32.6 0.0 1.8 1 0 0 1 1 1 1 RNA ligase mRNA_cap_enzyme PF01331.19 EDO18415.1 - 0.044 13.6 0.3 2.6 7.8 0.1 2.9 1 1 1 2 2 2 0 mRNA capping enzyme, catalytic domain DNA_ligase_A_C PF04679.15 EDO18415.1 - 0.084 13.5 0.0 0.19 12.4 0.0 1.6 1 0 0 1 1 1 0 ATP dependent DNA ligase C terminal region LIG3_BRCT PF16759.5 EDO18415.1 - 0.12 12.7 0.1 30 5.0 0.0 3.0 2 1 0 2 2 2 0 DNA ligase 3 BRCT domain DUF4507 PF14964.6 EDO18415.1 - 0.14 11.0 0.0 0.24 10.3 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4507) SGTA_dimer PF16546.5 EDO18416.1 - 1.8e-20 72.5 1.2 1.8e-20 72.5 1.2 2.1 2 0 0 2 2 2 1 Homodimerisation domain of SGTA TPR_1 PF00515.28 EDO18416.1 - 5.7e-18 63.9 10.1 8.2e-06 25.4 0.4 4.4 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_2 PF07719.17 EDO18416.1 - 6.8e-18 63.3 1.3 6.5e-05 22.7 0.1 4.8 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_11 PF13414.6 EDO18416.1 - 9.8e-13 47.6 6.7 2.9e-07 30.0 0.7 3.7 3 1 1 4 4 3 2 TPR repeat TPR_8 PF13181.6 EDO18416.1 - 4e-08 32.8 7.1 0.068 13.4 0.1 4.9 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_17 PF13431.6 EDO18416.1 - 2.7e-07 30.5 1.7 0.019 15.3 0.1 3.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 EDO18416.1 - 3.1e-05 24.2 1.1 0.63 10.4 0.1 3.1 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_19 PF14559.6 EDO18416.1 - 0.0011 19.4 0.6 0.16 12.5 0.2 3.0 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 EDO18416.1 - 0.0013 19.4 0.0 2.1 9.4 0.0 3.4 3 1 0 4 4 2 1 Tetratricopeptide repeat TPR_16 PF13432.6 EDO18416.1 - 0.0015 19.1 0.0 8.5 7.1 0.1 3.1 2 1 1 4 4 4 1 Tetratricopeptide repeat TPR_15 PF13429.6 EDO18416.1 - 0.024 13.9 0.4 0.065 12.4 0.3 1.5 1 1 0 1 1 1 0 Tetratricopeptide repeat TPR_7 PF13176.6 EDO18416.1 - 0.031 14.3 0.1 0.92 9.7 0.0 2.8 2 1 0 2 2 2 0 Tetratricopeptide repeat ChAPs PF09295.10 EDO18416.1 - 0.056 12.4 2.7 0.073 12.1 1.6 1.7 1 1 1 2 2 2 0 ChAPs (Chs5p-Arf1p-binding proteins) TPR_18 PF13512.6 EDO18416.1 - 0.094 12.8 5.2 0.031 14.4 2.2 1.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 EDO18416.1 - 0.18 12.5 4.6 13 6.7 0.0 3.6 5 0 0 5 5 3 0 Tetratricopeptide repeat ComX PF05952.12 EDO18416.1 - 0.31 11.0 3.7 7.4 6.6 0.0 3.6 4 0 0 4 4 4 0 Bacillus competence pheromone ComX KIP1 PF07765.12 EDO18416.1 - 0.46 10.6 3.7 8.1 6.6 0.2 3.5 3 1 0 3 3 3 0 KIP1-like protein HlyIII PF03006.20 EDO18417.1 - 5.8e-56 189.7 17.8 7.1e-56 189.4 17.8 1.1 1 0 0 1 1 1 1 Haemolysin-III related DUF613 PF04764.12 EDO18417.1 - 0.078 13.1 0.1 0.12 12.5 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF613) Pkinase PF00069.25 EDO18418.1 - 2.4e-53 181.2 0.4 5.9e-53 179.9 0.1 1.9 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO18418.1 - 7.4e-23 81.1 0.0 1.8e-22 79.9 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase FTA2 PF13095.6 EDO18418.1 - 9.1e-05 22.2 0.8 0.5 10.0 0.1 3.3 3 0 0 3 3 3 2 Kinetochore Sim4 complex subunit FTA2 RIO1 PF01163.22 EDO18418.1 - 0.036 13.7 0.6 0.088 12.4 0.6 1.7 1 0 0 1 1 1 0 RIO1 family DEAD PF00270.29 EDO18419.1 - 3.4e-51 173.5 0.1 1.8e-49 167.9 0.0 2.3 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDO18419.1 - 4.1e-25 88.3 0.6 5.6e-23 81.4 0.0 3.1 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DBP10CT PF08147.12 EDO18419.1 - 3.3e-18 65.7 5.9 3.3e-18 65.7 5.9 3.2 3 0 0 3 3 3 1 DBP10CT (NUC160) domain Inositol_P PF00459.25 EDO18420.1 - 4e-53 180.7 0.1 5.1e-52 177.1 0.1 1.9 1 1 0 1 1 1 1 Inositol monophosphatase family Git3 PF11710.8 EDO18421.1 - 2.5e-78 262.5 15.7 5.5e-78 261.4 15.7 1.6 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 GPR_Gpa2_C PF11970.8 EDO18421.1 - 7.1e-33 112.5 3.3 2.3e-32 110.9 3.3 2.0 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 C-term Inv-AAD PF18785.1 EDO18422.1 - 1.2e-35 122.1 0.0 2.3e-35 121.3 0.0 1.4 1 0 0 1 1 1 1 Invertebrate-AID/APOBEC-deaminase PseudoU_synth_2 PF00849.22 EDO18422.1 - 5.4e-32 111.1 0.5 9.8e-32 110.2 0.1 1.7 2 0 0 2 2 2 1 RNA pseudouridylate synthase dCMP_cyt_deam_1 PF00383.23 EDO18422.1 - 7.3e-17 61.1 0.0 1.4e-16 60.2 0.0 1.5 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 EDO18422.1 - 5e-05 23.1 0.0 9.2e-05 22.2 0.0 1.4 1 0 0 1 1 1 1 MafB19-like deaminase NARP1 PF12569.8 EDO18423.1 - 1.2e-114 384.0 29.3 2.4e-83 280.8 7.7 3.2 3 0 0 3 3 3 2 NMDA receptor-regulated protein 1 TPR_2 PF07719.17 EDO18423.1 - 8.5e-17 59.9 2.9 0.0014 18.6 0.0 8.2 9 0 0 9 9 7 3 Tetratricopeptide repeat TPR_16 PF13432.6 EDO18423.1 - 8.8e-13 48.7 0.0 0.061 14.0 0.0 5.7 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_19 PF14559.6 EDO18423.1 - 5.2e-12 46.1 1.3 0.049 14.1 0.0 5.9 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_14 PF13428.6 EDO18423.1 - 1.1e-11 44.4 0.0 0.038 14.8 0.0 7.3 6 1 1 7 7 7 2 Tetratricopeptide repeat TPR_8 PF13181.6 EDO18423.1 - 5.1e-09 35.7 9.2 0.00098 19.2 0.1 7.3 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_11 PF13414.6 EDO18423.1 - 3.1e-07 30.0 0.4 0.0015 18.2 0.1 4.5 5 0 0 5 5 5 1 TPR repeat TPR_12 PF13424.6 EDO18423.1 - 1.7e-06 28.2 0.2 0.95 9.8 0.0 5.8 7 1 1 8 8 5 2 Tetratricopeptide repeat TPR_1 PF00515.28 EDO18423.1 - 6.1e-06 25.8 11.3 0.018 14.9 0.0 6.1 8 0 0 8 8 7 2 Tetratricopeptide repeat TPR_17 PF13431.6 EDO18423.1 - 7.3e-06 26.0 0.6 3.7 8.1 0.0 6.2 7 0 0 7 7 6 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EDO18423.1 - 3.1e-05 24.0 3.4 0.12 12.5 0.1 4.1 4 0 0 4 4 4 2 Fis1 C-terminal tetratricopeptide repeat ANAPC3 PF12895.7 EDO18423.1 - 5.6e-05 23.3 13.0 0.039 14.2 0.1 6.0 6 1 1 7 7 7 2 Anaphase-promoting complex, cyclosome, subunit 3 HrpB1_HrpK PF09613.10 EDO18423.1 - 0.00088 18.9 0.0 0.41 10.3 0.0 3.4 3 0 0 3 3 3 1 Bacterial type III secretion protein (HrpB1_HrpK) TPR_7 PF13176.6 EDO18423.1 - 0.0022 17.9 0.0 2 8.6 0.0 4.5 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_6 PF13174.6 EDO18423.1 - 0.044 14.4 8.0 0.56 11.0 0.0 5.3 6 0 0 6 6 5 0 Tetratricopeptide repeat NPAT_C PF15712.5 EDO18423.1 - 2 7.0 6.8 3.4 6.2 6.8 1.2 1 0 0 1 1 1 0 NPAT C terminus Bud13 PF09736.9 EDO18423.1 - 3.1 8.2 14.2 0.2 12.1 8.6 1.9 2 0 0 2 2 1 0 Pre-mRNA-splicing factor of RES complex PDCD2_C PF04194.13 EDO18423.1 - 5 7.1 11.4 10 6.2 4.8 2.5 2 0 0 2 2 2 0 Programmed cell death protein 2, C-terminal putative domain SRP_TPR_like PF17004.5 EDO18423.1 - 7.5 6.6 14.2 0.44 10.6 0.3 4.8 4 2 0 5 5 5 0 Putative TPR-like repeat HLH PF00010.26 EDO18424.1 - 6.6e-15 54.8 0.0 1.1e-14 54.2 0.0 1.3 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain SIR2 PF02146.17 EDO18425.1 - 2.7e-67 226.1 0.0 7.3e-67 224.7 0.0 1.7 2 0 0 2 2 2 1 Sir2 family DUF592 PF04574.13 EDO18425.1 - 2.3e-63 212.6 3.1 4.6e-63 211.6 3.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF592) TPP_enzyme_M PF00205.22 EDO18425.1 - 0.0029 17.4 0.0 0.52 10.0 0.0 2.4 2 0 0 2 2 2 2 Thiamine pyrophosphate enzyme, central domain SF3A2 PF16835.5 EDO18426.1 - 6.6e-24 84.1 1.6 8.4e-24 83.8 0.1 1.8 2 0 0 2 2 2 1 Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11) zf-met PF12874.7 EDO18426.1 - 1.6e-06 28.3 1.9 1.6e-06 28.3 1.9 2.5 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 EDO18426.1 - 0.022 15.1 0.9 0.022 15.1 0.9 2.3 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-U1 PF06220.12 EDO18426.1 - 0.082 12.7 0.1 0.18 11.6 0.1 1.6 1 0 0 1 1 1 0 U1 zinc finger Fer4_17 PF13534.6 EDO18426.1 - 0.36 11.4 3.3 0.23 12.0 1.0 1.8 2 0 0 2 2 2 0 4Fe-4S dicluster domain OrsD PF12013.8 EDO18426.1 - 3.4 8.1 5.6 0.38 11.2 0.2 2.2 2 1 1 3 3 3 0 Orsellinic acid/F9775 biosynthesis cluster protein D Nuf2 PF03800.14 EDO18427.1 - 2.3e-41 141.1 0.0 2.3e-41 141.1 0.0 3.3 2 1 0 3 3 3 1 Nuf2 family DHR10 PF18595.1 EDO18427.1 - 0.0028 17.7 18.8 0.0028 17.7 18.8 4.6 3 1 2 5 5 5 2 Designed helical repeat protein 10 domain PI_PP_I PF18363.1 EDO18427.1 - 7.7 6.8 9.6 3.5 7.9 1.8 3.3 1 1 1 3 3 3 0 Phosphoinositide phosphatase insertion domain PAPS_reduct PF01507.19 EDO18430.1 - 5.7e-31 107.9 0.0 7.8e-31 107.4 0.0 1.2 1 0 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family CHCH PF06747.13 EDO18431.1 - 4.3e-05 23.5 0.3 5.9e-05 23.1 0.3 1.2 1 0 0 1 1 1 1 CHCH domain Cmc1 PF08583.10 EDO18431.1 - 0.0011 18.9 0.9 0.0013 18.7 0.9 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like CX9C PF16860.5 EDO18431.1 - 0.27 11.3 2.1 0.42 10.7 2.1 1.4 1 0 0 1 1 1 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, Sdh5 PF03937.16 EDO18432.1 - 6.8e-27 93.2 0.7 1e-26 92.6 0.7 1.3 1 0 0 1 1 1 1 Flavinator of succinate dehydrogenase HhH-GPD PF00730.25 EDO18433.1 - 3.4e-10 40.3 0.0 1.8e-09 38.0 0.0 1.9 2 0 0 2 2 2 1 HhH-GPD superfamily base excision DNA repair protein Jacalin PF01419.17 EDO18433.1 - 0.049 13.6 0.2 2.7 7.9 0.0 2.3 2 0 0 2 2 2 0 Jacalin-like lectin domain BLYB PF05289.11 EDO18433.1 - 0.35 11.1 2.9 0.89 9.8 0.1 2.8 3 0 0 3 3 3 0 Borrelia hemolysin accessory protein BSD PF03909.17 EDO18434.1 - 1.4e-14 53.8 0.1 1.4e-14 53.8 0.1 3.1 3 0 0 3 3 3 1 BSD domain DUF4604 PF15377.6 EDO18434.1 - 0.016 15.6 22.6 0.016 15.6 22.6 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4604) MCPVI PF02993.14 EDO18434.1 - 0.17 11.7 0.0 0.17 11.7 0.0 2.9 2 1 1 3 3 3 0 Minor capsid protein VI DUF1890 PF09001.11 EDO18434.1 - 0.51 10.7 0.0 0.51 10.7 0.0 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF1890) PGA_cap PF09587.10 EDO18434.1 - 1.3 8.4 9.0 5.7 6.3 4.0 2.5 2 1 0 2 2 2 0 Bacterial capsule synthesis protein PGA_cap UCH PF00443.29 EDO18435.1 - 2.7e-63 213.8 0.4 7.2e-63 212.5 0.4 1.7 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EDO18435.1 - 1.3e-22 80.8 0.8 2.9e-22 79.7 0.8 1.6 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Rhodanese PF00581.20 EDO18435.1 - 2.4e-08 34.4 0.0 5.8e-08 33.2 0.0 1.7 1 0 0 1 1 1 1 Rhodanese-like domain zf-MIZ PF02891.20 EDO18435.1 - 0.011 15.5 0.6 0.029 14.1 0.6 1.7 1 0 0 1 1 1 0 MIZ/SP-RING zinc finger TcdB_N PF12918.7 EDO18435.1 - 0.07 13.4 3.1 6.1 7.2 0.0 3.1 3 0 0 3 3 3 0 TcdB toxin N-terminal helical domain RNA_pol_Rpb1_4 PF05000.17 EDO18435.1 - 0.079 12.9 0.3 0.29 11.1 0.3 2.0 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 4 Acetyltransf_1 PF00583.25 EDO18436.1 - 3.7e-19 69.1 0.0 5e-19 68.7 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EDO18436.1 - 7.2e-13 48.6 0.0 9.5e-13 48.2 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EDO18436.1 - 2.9e-06 27.6 0.0 4.2e-06 27.1 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EDO18436.1 - 0.0087 16.0 0.0 0.016 15.2 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_15 PF17013.5 EDO18436.1 - 0.031 13.7 0.0 0.053 13.0 0.0 1.5 2 0 0 2 2 2 0 Putative acetyl-transferase Acetyltransf_8 PF13523.6 EDO18436.1 - 0.038 13.7 0.0 0.072 12.8 0.0 1.4 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 EDO18436.1 - 0.092 12.9 0.0 0.13 12.4 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain FTR1 PF03239.14 EDO18437.1 - 8.8e-99 330.5 7.1 1.3e-98 330.0 7.1 1.2 1 0 0 1 1 1 1 Iron permease FTR1 family DSRB PF10781.9 EDO18437.1 - 0.076 12.7 0.0 0.19 11.4 0.0 1.6 1 0 0 1 1 1 0 Dextransucrase DSRB GWT1 PF06423.12 EDO18437.1 - 0.094 12.8 0.1 0.73 10.0 0.0 2.3 2 0 0 2 2 2 0 GWT1 Rop PF01815.16 EDO18437.1 - 0.15 11.9 0.3 0.32 10.9 0.3 1.5 1 0 0 1 1 1 0 Rop protein PAP2_3 PF14378.6 EDO18438.1 - 1.2e-12 47.9 13.9 1.8e-11 44.1 2.0 2.7 3 0 0 3 3 3 2 PAP2 superfamily PAP2 PF01569.21 EDO18438.1 - 1.9e-06 27.7 15.7 1.9e-05 24.5 0.6 3.7 4 1 1 5 5 5 2 PAP2 superfamily SpoIIM PF01944.17 EDO18438.1 - 0.12 12.4 7.5 0.35 10.9 7.5 1.8 1 0 0 1 1 1 0 Stage II sporulation protein M DUF5325 PF17259.2 EDO18438.1 - 0.22 11.4 1.4 0.93 9.4 0.1 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5325) Phospholamban PF04272.14 EDO18438.1 - 6.4 6.3 7.3 1.3 8.6 0.4 2.7 2 0 0 2 2 2 0 Phospholamban Glyco_transf_20 PF00982.21 EDO18440.1 - 1.1e-138 462.8 6.8 1.8e-138 462.2 6.8 1.4 1 1 0 1 1 1 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.16 EDO18440.1 - 8.9e-81 270.4 0.0 1.4e-80 269.8 0.0 1.3 1 0 0 1 1 1 1 Trehalose-phosphatase Cohesin_load PF10345.9 EDO18441.1 - 1.2e-162 542.5 34.9 1.4e-162 542.3 34.9 1.0 1 0 0 1 1 1 1 Cohesin loading factor Hormone_3 PF00159.18 EDO18441.1 - 0.23 11.6 2.6 0.71 10.0 0.2 2.7 2 0 0 2 2 2 0 Pancreatic hormone peptide TBP PF00352.21 EDO18442.1 - 2.4e-68 226.1 0.1 7.3e-33 112.4 0.1 2.3 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) DUF3378 PF11858.8 EDO18442.1 - 2.2e-05 24.5 0.1 0.25 11.5 0.0 2.7 2 1 1 3 3 3 2 Domain of unknown function (DUF3378) DUF4295 PF14128.6 EDO18442.1 - 0.037 13.8 0.2 0.28 11.0 0.0 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4295) Metallophos PF00149.28 EDO18443.1 - 2.3e-38 132.7 0.2 2.9e-38 132.4 0.2 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EDO18443.1 - 0.013 15.7 0.0 0.019 15.2 0.0 1.3 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain 8TM_micro PF17028.5 EDO18443.1 - 0.081 12.6 0.1 0.1 12.3 0.1 1.2 1 0 0 1 1 1 0 8TM Microsporidial transmembrane domain ATPase PF06745.13 EDO18444.1 - 1e-08 34.9 0.1 3.9e-08 32.9 0.1 2.0 1 1 0 1 1 1 1 KaiC Rad51 PF08423.11 EDO18444.1 - 1.3e-07 31.2 0.0 4.2e-07 29.5 0.0 1.8 1 1 0 1 1 1 1 Rad51 ATPase_2 PF01637.18 EDO18444.1 - 9.3e-05 22.4 2.0 0.00031 20.7 0.5 2.1 2 0 0 2 2 2 1 ATPase domain predominantly from Archaea AAA_22 PF13401.6 EDO18444.1 - 0.00015 22.1 0.0 0.00039 20.7 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EDO18444.1 - 0.0022 18.4 0.0 0.0056 17.1 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain DnaB_C PF03796.15 EDO18444.1 - 0.0023 17.3 0.0 0.027 13.8 0.0 2.4 2 1 0 2 2 2 1 DnaB-like helicase C terminal domain AAA_24 PF13479.6 EDO18444.1 - 0.005 16.6 0.0 0.015 15.0 0.0 1.8 1 0 0 1 1 1 1 AAA domain RecA PF00154.21 EDO18444.1 - 0.0057 16.2 0.0 0.011 15.2 0.0 1.5 1 0 0 1 1 1 1 recA bacterial DNA recombination protein T2SSE PF00437.20 EDO18444.1 - 0.0068 15.5 0.2 0.47 9.5 0.1 2.2 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_25 PF13481.6 EDO18444.1 - 0.013 15.1 0.0 0.031 13.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.22 EDO18444.1 - 0.013 14.7 0.0 0.034 13.3 0.0 1.7 2 1 0 2 2 2 0 NB-ARC domain AAA PF00004.29 EDO18444.1 - 0.035 14.5 0.5 0.098 13.1 0.0 2.1 3 1 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) AAA_11 PF13086.6 EDO18444.1 - 0.046 13.5 0.6 0.56 9.9 0.0 2.2 2 0 0 2 2 2 0 AAA domain Aminotran_1_2 PF00155.21 EDO18445.1 - 6.1e-18 65.1 0.0 8.6e-18 64.6 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_MocR PF12897.7 EDO18445.1 - 0.00049 19.0 0.0 0.00069 18.5 0.0 1.4 1 1 0 1 1 1 1 Alanine-glyoxylate amino-transferase DUF2334 PF10096.9 EDO18445.1 - 0.12 12.0 0.5 0.26 10.9 0.1 1.6 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2334) UPF0160 PF03690.13 EDO18446.1 - 4.1e-131 437.3 0.0 4.6e-131 437.2 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0160) Pet100 PF09803.9 EDO18447.1 - 5.1e-10 39.7 0.1 7.9e-10 39.1 0.1 1.3 1 0 0 1 1 1 1 Pet100 ATPase_gene1 PF09527.10 EDO18447.1 - 0.025 14.7 0.1 0.036 14.2 0.1 1.1 1 0 0 1 1 1 0 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter Sec34 PF04136.15 EDO18448.1 - 7.1e-43 146.1 7.7 7.1e-43 146.1 7.7 3.7 4 0 0 4 4 4 1 Sec34-like family BLOC1_2 PF10046.9 EDO18448.1 - 0.69 10.3 11.7 0.22 11.8 3.3 3.5 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Syntaxin_2 PF14523.6 EDO18448.1 - 0.76 10.2 8.8 0.1 13.0 0.7 3.6 5 0 0 5 5 5 0 Syntaxin-like protein Occludin_ELL PF07303.13 EDO18448.1 - 1 10.1 11.2 0.25 12.1 1.3 4.2 3 1 1 4 4 4 0 Occludin homology domain DDE_1 PF03184.19 EDO18449.1 - 1.3e-61 207.3 2.9 2.8e-61 206.2 2.9 1.6 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EDO18449.1 - 2.3e-13 50.0 0.1 6.6e-13 48.5 0.1 1.8 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_ABP1_N PF18107.1 EDO18449.1 - 0.0041 16.8 0.4 0.012 15.4 0.1 2.0 2 0 0 2 2 2 1 Fission yeast centromere protein N-terminal domain Stn1 PF10451.9 EDO18450.1 - 9.1e-101 336.1 2.5 1.4e-100 335.5 2.5 1.2 1 0 0 1 1 1 1 Telomere regulation protein Stn1 Stn1_C PF12659.7 EDO18450.1 - 3.1e-30 104.6 5.8 6e-30 103.7 5.8 1.5 1 0 0 1 1 1 1 Telomere capping C-terminal wHTH Sex_peptide PF08138.11 EDO18450.1 - 0.011 15.8 0.2 0.027 14.6 0.2 1.6 1 0 0 1 1 1 0 Sex peptide (SP) family DUF2183 PF09949.9 EDO18450.1 - 0.026 14.9 0.8 0.076 13.4 0.2 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2183) Methyltransf_8 PF05148.15 EDO18451.1 - 4.2e-65 219.7 2.4 1.5e-62 211.4 0.2 2.8 1 1 1 2 2 2 2 Hypothetical methyltransferase Methyltransf_11 PF08241.12 EDO18451.1 - 3.9e-07 30.6 0.0 9.1e-07 29.4 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDO18451.1 - 2.6e-05 24.8 0.0 9e-05 23.1 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDO18451.1 - 0.00031 20.6 0.2 0.0021 17.9 0.2 2.2 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EDO18451.1 - 0.015 14.9 0.0 0.19 11.3 0.0 2.1 1 1 0 1 1 1 0 Methyltransferase small domain Methyltransf_32 PF13679.6 EDO18451.1 - 0.22 11.5 0.0 0.22 11.5 0.0 2.3 3 0 0 3 3 3 0 Methyltransferase domain Slu7 PF11708.8 EDO18452.1 - 5.2e-17 62.5 15.5 5.3e-14 52.6 1.9 2.7 3 0 0 3 3 3 2 Pre-mRNA splicing Prp18-interacting factor DUF3772 PF12607.8 EDO18452.1 - 0.16 11.8 0.6 0.36 10.6 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3772) PQ-loop PF04193.14 EDO18453.1 - 5.2e-20 71.0 9.4 6.4e-17 61.1 3.1 2.7 2 0 0 2 2 2 2 PQ loop repeat ABC_tran PF00005.27 EDO18454.1 - 3.4e-34 118.3 0.0 2.1e-16 60.7 0.0 2.5 2 1 0 2 2 2 2 ABC transporter RLI PF04068.15 EDO18454.1 - 7.4e-14 51.3 4.8 1.8e-13 50.0 4.8 1.7 1 0 0 1 1 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI AAA_21 PF13304.6 EDO18454.1 - 4.2e-10 39.9 7.7 0.057 13.2 0.1 4.2 2 2 2 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EDO18454.1 - 1.3e-07 31.3 3.5 0.022 14.2 0.3 3.9 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain Fer4 PF00037.27 EDO18454.1 - 3.4e-07 29.8 3.5 3.4e-07 29.8 3.5 2.6 3 0 0 3 3 3 1 4Fe-4S binding domain AAA_16 PF13191.6 EDO18454.1 - 3.7e-06 27.4 0.0 0.0057 17.1 0.0 2.4 2 0 0 2 2 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 EDO18454.1 - 7.3e-06 26.0 0.0 0.07 13.0 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase AAA PF00004.29 EDO18454.1 - 1e-05 26.0 0.0 0.041 14.3 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_15 PF13175.6 EDO18454.1 - 1.1e-05 25.4 0.1 0.21 11.3 0.0 3.2 3 0 0 3 3 3 2 AAA ATPase domain AAA_22 PF13401.6 EDO18454.1 - 8.6e-05 22.8 0.0 0.025 14.8 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 EDO18454.1 - 0.00015 21.4 0.7 0.44 10.3 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain Rad17 PF03215.15 EDO18454.1 - 0.00023 21.2 0.1 0.35 10.8 0.1 2.8 2 1 1 3 3 3 1 Rad17 P-loop domain Fer4_6 PF12837.7 EDO18454.1 - 0.00049 20.1 13.2 0.00077 19.4 3.1 2.5 2 0 0 2 2 2 1 4Fe-4S binding domain Fer4_21 PF14697.6 EDO18454.1 - 0.0007 19.7 12.0 0.0018 18.4 12.0 1.7 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_7 PF12838.7 EDO18454.1 - 0.001 19.6 7.3 0.0011 19.5 0.3 2.5 2 0 0 2 2 2 1 4Fe-4S dicluster domain AAA_30 PF13604.6 EDO18454.1 - 0.0011 18.7 0.2 0.086 12.5 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_23 PF13476.6 EDO18454.1 - 0.0012 19.3 2.5 0.041 14.4 0.0 2.5 2 1 0 2 2 2 1 AAA domain AAA_28 PF13521.6 EDO18454.1 - 0.0026 18.0 0.1 1.4 9.1 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EDO18454.1 - 0.0035 17.5 0.0 1.9 8.7 0.0 2.5 2 0 0 2 2 2 1 AAA domain Fer4_10 PF13237.6 EDO18454.1 - 0.0042 17.2 1.2 0.0042 17.2 1.2 2.4 1 1 1 2 2 2 1 4Fe-4S dicluster domain Fer4_9 PF13187.6 EDO18454.1 - 0.0047 17.1 10.4 0.011 15.9 10.4 1.6 1 1 0 1 1 1 1 4Fe-4S dicluster domain RNA_helicase PF00910.22 EDO18454.1 - 0.0047 17.3 0.0 1.8 9.0 0.0 2.9 3 0 0 3 3 2 1 RNA helicase AAA_24 PF13479.6 EDO18454.1 - 0.0048 16.7 1.0 0.72 9.5 0.0 2.3 2 0 0 2 2 2 1 AAA domain Fer4_2 PF12797.7 EDO18454.1 - 0.0056 16.7 0.8 0.0056 16.7 0.8 2.5 2 0 0 2 2 2 1 4Fe-4S binding domain NACHT PF05729.12 EDO18454.1 - 0.009 15.9 1.5 0.66 9.9 0.0 2.4 2 0 0 2 2 2 1 NACHT domain NB-ARC PF00931.22 EDO18454.1 - 0.0093 15.2 0.1 2.2 7.4 0.0 2.3 2 0 0 2 2 2 1 NB-ARC domain Fer4_16 PF13484.6 EDO18454.1 - 0.015 16.2 0.2 0.015 16.2 0.2 2.6 2 0 0 2 2 2 0 4Fe-4S double cluster binding domain SRP54 PF00448.22 EDO18454.1 - 0.02 14.5 3.2 0.68 9.5 0.1 2.2 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_5 PF07728.14 EDO18454.1 - 0.023 14.7 1.1 0.22 11.5 0.0 2.5 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) TsaE PF02367.17 EDO18454.1 - 0.026 14.5 0.0 0.71 9.9 0.0 2.3 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_18 PF13238.6 EDO18454.1 - 0.026 15.1 0.0 11 6.6 0.0 2.8 2 0 0 2 2 2 0 AAA domain TniB PF05621.11 EDO18454.1 - 0.029 13.8 0.1 8.7 5.7 0.0 3.1 3 0 0 3 3 3 0 Bacterial TniB protein MMR_HSR1 PF01926.23 EDO18454.1 - 0.036 14.1 0.3 6.4 6.9 0.0 2.5 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_7 PF12775.7 EDO18454.1 - 0.041 13.4 0.2 0.46 10.0 0.0 2.2 2 0 0 2 2 2 0 P-loop containing dynein motor region Fer4_17 PF13534.6 EDO18454.1 - 0.05 14.2 0.1 0.05 14.2 0.1 2.4 2 0 0 2 2 2 0 4Fe-4S dicluster domain SbcCD_C PF13558.6 EDO18454.1 - 0.071 13.4 0.1 29 5.0 0.0 3.0 2 2 0 2 2 2 0 Putative exonuclease SbcCD, C subunit AAA_14 PF13173.6 EDO18454.1 - 0.075 13.1 0.0 14 5.8 0.0 2.8 2 0 0 2 2 2 0 AAA domain DLIC PF05783.11 EDO18454.1 - 0.12 11.2 0.0 0.25 10.1 0.0 1.4 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) VirE PF05272.11 EDO18454.1 - 0.14 11.9 0.0 6.1 6.5 0.0 2.4 2 0 0 2 2 2 0 Virulence-associated protein E AAA_13 PF13166.6 EDO18454.1 - 0.15 10.6 0.2 0.55 8.8 0.0 1.9 2 0 0 2 2 2 0 AAA domain Fer4_8 PF13183.6 EDO18454.1 - 0.17 12.4 0.1 0.17 12.4 0.1 2.4 2 0 0 2 2 2 0 4Fe-4S dicluster domain Fer4_4 PF12800.7 EDO18454.1 - 0.66 10.6 14.6 0.32 11.6 2.7 2.5 2 0 0 2 2 2 0 4Fe-4S binding domain RRM_1 PF00076.22 EDO18455.1 - 4.2e-85 279.6 6.5 3.9e-21 74.6 0.8 4.6 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP PF00658.18 EDO18455.1 - 5.4e-18 64.9 1.1 1.7e-17 63.3 0.1 2.4 3 0 0 3 3 3 1 Poly-adenylate binding protein, unique domain RRM_5 PF13893.6 EDO18455.1 - 4.5e-08 32.7 0.0 0.32 10.6 0.0 3.8 1 1 2 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EDO18455.1 - 4.2e-07 30.0 2.4 0.088 12.9 0.0 5.2 4 4 0 4 4 4 1 RNA recognition motif Nup35_RRM_2 PF14605.6 EDO18455.1 - 2.5e-05 24.2 1.6 0.26 11.3 0.1 3.5 3 0 0 3 3 3 2 Nup53/35/40-type RNA recognition motif DUF4523 PF15023.6 EDO18455.1 - 4.4e-05 23.4 0.0 1.8 8.4 0.0 3.5 2 2 1 3 3 3 2 Protein of unknown function (DUF4523) RRM_3 PF08777.11 EDO18455.1 - 4.4e-05 23.5 10.2 0.55 10.3 2.8 4.8 4 1 1 5 5 5 2 RNA binding motif RRM_occluded PF16842.5 EDO18455.1 - 0.00016 21.5 0.0 0.028 14.3 0.0 3.5 4 0 0 4 4 4 1 Occluded RNA-recognition motif OB_RNB PF08206.11 EDO18455.1 - 0.022 14.4 2.1 7.6 6.3 0.0 3.7 3 0 0 3 3 3 0 Ribonuclease B OB domain BBE PF08031.12 EDO18455.1 - 0.062 13.4 0.3 8.2 6.6 0.1 2.6 2 0 0 2 2 2 0 Berberine and berberine like Nefa_Nip30_N PF10187.9 EDO18455.1 - 0.074 13.4 0.3 0.074 13.4 0.3 3.5 4 0 0 4 4 3 0 N-terminal domain of NEFA-interacting nuclear protein NIP30 YflT PF11181.8 EDO18455.1 - 0.24 11.9 11.8 0.19 12.2 1.4 3.5 3 1 1 4 4 4 0 Heat induced stress protein YflT Neur_chan_memb PF02932.16 EDO18457.1 - 0.35 10.9 12.4 1.2 9.1 6.5 2.2 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region BPS1 PF05633.11 EDO18457.1 - 2.1 7.3 4.8 3.4 6.6 3.8 1.8 1 1 0 1 1 1 0 Protein BYPASS1-related JmjC PF02373.22 EDO18458.1 - 5.1e-07 30.1 0.4 4.8e-06 27.0 0.0 2.7 2 0 0 2 2 2 1 JmjC domain, hydroxylase zf-H2C2_2 PF13465.6 EDO18458.1 - 1.6e-06 28.3 6.7 1.6e-06 28.3 6.7 2.3 2 0 0 2 2 2 1 Zinc-finger double domain zf-C2H2 PF00096.26 EDO18458.1 - 3.6e-05 24.0 15.4 0.0085 16.5 2.6 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_6 PF13912.6 EDO18458.1 - 6e-05 22.9 12.2 0.00017 21.5 5.0 2.5 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2H2_4 PF13894.6 EDO18458.1 - 0.00031 21.3 17.1 0.066 14.1 4.9 3.1 3 0 0 3 3 2 2 C2H2-type zinc finger Zn-ribbon_8 PF09723.10 EDO18458.1 - 0.0044 17.1 3.3 0.0096 16.0 3.3 1.6 1 0 0 1 1 1 1 Zinc ribbon domain HypA PF01155.19 EDO18458.1 - 0.063 13.3 0.6 0.13 12.3 0.6 1.4 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-C2H2_8 PF15909.5 EDO18458.1 - 0.069 13.5 2.4 0.21 11.9 2.4 1.9 1 0 0 1 1 1 0 C2H2-type zinc ribbon zf_UBZ PF18439.1 EDO18458.1 - 0.27 10.8 3.6 9.1 6.0 0.3 2.6 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger DZR PF12773.7 EDO18458.1 - 0.28 11.3 1.1 0.65 10.1 1.1 1.7 1 0 0 1 1 1 0 Double zinc ribbon zf-C2H2_jaz PF12171.8 EDO18458.1 - 0.28 11.5 11.2 0.26 11.6 5.2 2.5 1 1 1 2 2 2 0 Zinc-finger double-stranded RNA-binding zinc_ribbon_15 PF17032.5 EDO18458.1 - 0.62 10.9 2.8 2.4 9.0 1.7 2.2 2 0 0 2 2 2 0 zinc-ribbon family zf-C2H2_11 PF16622.5 EDO18458.1 - 0.7 9.7 8.7 0.14 11.9 3.7 2.4 2 0 0 2 2 2 0 zinc-finger C2H2-type zf-met PF12874.7 EDO18458.1 - 2.8 8.4 7.4 12 6.5 0.5 2.8 2 0 0 2 2 2 0 Zinc-finger of C2H2 type LIM PF00412.22 EDO18458.1 - 3 8.1 5.1 37 4.6 0.4 2.2 1 1 1 2 2 2 0 LIM domain zinc_ribbon_5 PF13719.6 EDO18458.1 - 3.5 7.5 4.4 0.87 9.4 1.0 1.8 2 0 0 2 2 1 0 zinc-ribbon domain ADK PF00406.22 EDO18459.1 - 2.4e-41 141.3 0.0 2.9e-41 141.1 0.0 1.0 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 EDO18459.1 - 9.1e-19 68.2 0.0 1.5e-18 67.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain ADK_lid PF05191.14 EDO18459.1 - 1e-13 51.0 0.1 1.7e-13 50.3 0.1 1.4 1 0 0 1 1 1 1 Adenylate kinase, active site lid AAA_18 PF13238.6 EDO18459.1 - 0.00013 22.6 0.0 0.00024 21.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 EDO18459.1 - 0.014 14.8 0.1 0.023 14.1 0.1 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_33 PF13671.6 EDO18459.1 - 0.017 15.3 0.5 0.16 12.1 0.1 2.3 2 1 0 2 2 2 0 AAA domain DEAD_2 PF06733.15 EDO18460.1 - 3.8e-57 192.7 3.2 7e-57 191.9 3.2 1.5 1 0 0 1 1 1 1 DEAD_2 HBB PF06777.11 EDO18460.1 - 3.7e-45 153.9 4.1 2.6e-41 141.4 1.6 2.6 2 0 0 2 2 2 2 Helical and beta-bridge domain Helicase_C_2 PF13307.6 EDO18460.1 - 1.5e-44 152.2 0.0 5.3e-44 150.4 0.0 2.0 2 0 0 2 2 2 1 Helicase C-terminal domain ResIII PF04851.15 EDO18460.1 - 0.0009 19.3 0.1 0.035 14.1 0.1 2.5 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit Methyltransf_25 PF13649.6 EDO18461.1 - 2.5e-12 47.4 0.0 4.4e-12 46.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EDO18461.1 - 4.2e-12 46.6 0.0 6.9e-12 45.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDO18461.1 - 6.2e-12 45.6 0.0 9.8e-12 44.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EDO18461.1 - 1.9e-10 41.4 0.1 2e-09 38.1 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 EDO18461.1 - 1.8e-07 31.2 0.0 2.3e-07 30.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 EDO18461.1 - 6.6e-05 22.3 0.1 0.00012 21.4 0.1 1.6 1 1 0 1 1 1 1 Mycolic acid cyclopropane synthetase Ubie_methyltran PF01209.18 EDO18461.1 - 0.00013 21.4 0.0 0.0002 20.8 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family NodS PF05401.11 EDO18461.1 - 0.011 15.3 0.0 0.017 14.7 0.0 1.2 1 0 0 1 1 1 0 Nodulation protein S (NodS) MTS PF05175.14 EDO18461.1 - 0.014 15.0 0.0 0.023 14.3 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain PCMT PF01135.19 EDO18461.1 - 0.015 15.1 0.0 0.025 14.3 0.0 1.4 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Pox_MCEL PF03291.16 EDO18461.1 - 0.015 14.4 0.7 0.025 13.7 0.1 1.6 2 0 0 2 2 2 0 mRNA capping enzyme Rsm22 PF09243.10 EDO18461.1 - 0.024 13.9 0.0 0.036 13.3 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial small ribosomal subunit Rsm22 Methyltransf_4 PF02390.17 EDO18461.1 - 0.028 13.9 0.0 0.049 13.1 0.0 1.4 1 0 0 1 1 1 0 Putative methyltransferase Methyltransf_9 PF08003.11 EDO18461.1 - 0.074 12.0 0.1 0.62 8.9 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1698) Rrn6 PF10214.9 EDO18462.1 - 4.6e-141 472.1 31.0 4.6e-141 472.1 31.0 1.8 2 1 0 2 2 2 1 RNA polymerase I-specific transcription-initiation factor Formyl_trans_N PF00551.19 EDO18463.1 - 3.8e-30 105.0 0.0 5.6e-30 104.4 0.0 1.2 1 0 0 1 1 1 1 Formyl transferase Formyl_trans_C PF02911.18 EDO18463.1 - 0.00035 20.8 0.0 0.00066 19.9 0.0 1.5 1 0 0 1 1 1 1 Formyl transferase, C-terminal domain Haspin_kinase PF12330.8 EDO18464.1 - 4e-93 312.3 15.9 7.5e-93 311.4 15.9 1.4 1 0 0 1 1 1 1 Haspin like kinase domain Pkinase_Tyr PF07714.17 EDO18464.1 - 0.013 14.8 0.0 0.023 14.0 0.0 1.3 1 0 0 1 1 1 0 Protein tyrosine kinase ATE_C PF04377.15 EDO18465.1 - 5.9e-41 140.2 0.6 1.2e-40 139.2 0.6 1.5 1 0 0 1 1 1 1 Arginine-tRNA-protein transferase, C terminus ATE_N PF04376.13 EDO18465.1 - 4.2e-24 84.7 2.8 1e-23 83.5 2.8 1.7 1 0 0 1 1 1 1 Arginine-tRNA-protein transferase, N terminus Inhibitor_I67 PF11405.8 EDO18465.1 - 0.13 12.6 2.7 14 6.0 0.0 2.9 2 0 0 2 2 2 0 Bromelain inhibitor VI UME PF08064.13 EDO18466.1 - 0.0033 17.3 0.0 1.4 8.8 0.0 4.2 3 0 0 3 3 3 2 UME (NUC010) domain WD40 PF00400.32 EDO18467.1 - 4.8e-34 115.8 15.6 1.4e-08 35.2 0.1 8.3 8 0 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDO18467.1 - 4e-14 52.7 0.0 0.64 10.4 0.0 6.0 4 1 2 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain HIRA_B PF09453.10 EDO18467.1 - 2.2e-10 40.1 3.4 2.4e-10 40.0 0.2 2.5 2 0 0 2 2 2 1 HIRA B motif Hira PF07569.11 EDO18467.1 - 5.6e-07 29.5 0.0 1.3e-06 28.3 0.0 1.7 1 0 0 1 1 1 1 TUP1-like enhancer of split PD40 PF07676.12 EDO18467.1 - 1.9e-06 27.7 0.3 1.5 8.9 0.0 5.3 6 0 0 6 6 6 2 WD40-like Beta Propeller Repeat Ge1_WD40 PF16529.5 EDO18467.1 - 0.00051 19.1 0.0 0.27 10.1 0.0 3.0 2 1 1 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nbas_N PF15492.6 EDO18467.1 - 0.012 15.0 0.0 0.047 13.0 0.0 2.1 2 0 0 2 2 2 0 Neuroblastoma-amplified sequence, N terminal SBD PF17882.1 EDO18467.1 - 0.098 12.5 0.0 0.22 11.3 0.0 1.6 1 0 0 1 1 1 0 OAA-family lectin sugar binding domain Reg_prop PF07494.11 EDO18467.1 - 0.23 11.8 1.4 9.2 6.9 0.0 4.0 4 0 0 4 4 4 0 Two component regulator propeller nsp7 PF08716.10 EDO18468.1 - 0.28 11.8 3.4 1.1 9.9 0.1 2.7 2 1 1 3 3 3 0 nsp7 replicase DUF3432 PF11914.8 EDO18469.1 - 0.00053 20.2 20.4 0.00053 20.2 20.4 3.3 2 1 1 3 3 3 2 Domain of unknown function (DUF3432) 4F5 PF04419.14 EDO18470.1 - 3.5e-10 40.6 12.8 3.5e-10 40.6 12.8 2.2 2 0 0 2 2 2 1 4F5 protein family WD40 PF00400.32 EDO18471.1 - 6.9e-22 77.3 2.6 2.6e-05 24.9 0.2 6.3 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDO18471.1 - 1.5e-08 34.8 0.1 0.00032 20.9 0.1 3.9 3 2 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EDO18471.1 - 6.7e-05 22.8 0.2 0.37 10.6 0.1 3.0 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A SGL PF08450.12 EDO18471.1 - 0.0034 17.0 0.1 0.0097 15.5 0.0 1.8 2 0 0 2 2 2 1 SMP-30/Gluconolactonase/LRE-like region Coatomer_WDAD PF04053.14 EDO18471.1 - 0.0077 15.3 0.3 0.035 13.2 0.1 1.9 2 0 0 2 2 2 1 Coatomer WD associated region PQQ PF01011.21 EDO18471.1 - 0.062 13.2 0.2 0.84 9.7 0.0 2.7 3 0 0 3 3 3 0 PQQ enzyme repeat COPI_C PF06957.11 EDO18471.1 - 0.084 11.6 0.0 0.12 11.1 0.0 1.1 1 0 0 1 1 1 0 Coatomer (COPI) alpha subunit C-terminus T5orf172 PF10544.9 EDO18472.1 - 1.4e-09 38.4 0.2 1.4e-07 32.0 0.2 2.3 1 1 0 1 1 1 1 T5orf172 domain MUG113 PF13455.6 EDO18472.1 - 5e-07 30.3 0.1 6.8e-06 26.7 0.1 2.2 1 1 0 1 1 1 1 Meiotically up-regulated gene 113 Laminin_B PF00052.18 EDO18472.1 - 0.12 12.3 0.0 0.22 11.4 0.0 1.4 1 0 0 1 1 1 0 Laminin B (Domain IV) Osw5 PF17062.5 EDO18474.1 - 4.8e-30 103.4 12.7 7.3e-30 102.9 12.7 1.3 1 0 0 1 1 1 1 Outer spore wall 5 ADH_zinc_N_2 PF13602.6 EDO18475.1 - 1.8e-15 58.1 0.0 4.5e-15 56.9 0.0 1.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EDO18475.1 - 1.3e-05 25.0 0.1 2.8e-05 24.0 0.1 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EDO18475.1 - 1.5e-05 25.0 0.0 4.1e-05 23.6 0.0 1.8 2 0 0 2 2 2 1 Zinc-binding dehydrogenase DUF2855 PF11017.8 EDO18475.1 - 0.004 17.0 0.0 0.0055 16.5 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2855) DUF2418 PF10332.9 EDO18476.1 - 5.4e-28 97.4 1.3 5.4e-28 97.4 1.3 2.3 3 0 0 3 3 3 1 Protein of unknown function (DUF2418) UBX PF00789.20 EDO18478.1 - 9.1e-18 64.2 0.0 1.7e-17 63.4 0.0 1.5 1 0 0 1 1 1 1 UBX domain PMT PF02366.18 EDO18479.1 - 6.5e-80 268.2 18.0 1.3e-79 267.3 18.0 1.4 1 0 0 1 1 1 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 EDO18479.1 - 4e-57 193.0 17.7 4e-57 193.0 17.7 2.1 2 1 0 2 2 2 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 EDO18479.1 - 4.1e-45 153.9 0.3 4.1e-45 153.9 0.3 2.0 2 0 0 2 2 1 1 MIR domain S_100 PF01023.19 EDO18479.1 - 2.3e-06 27.2 0.0 0.84 9.4 0.0 3.7 3 0 0 3 3 3 3 S-100/ICaBP type calcium binding domain ICAT PF06384.11 EDO18479.1 - 0.00037 20.7 0.0 18 5.7 0.0 4.1 4 0 0 4 4 4 0 Beta-catenin-interacting protein ICAT PMT_2 PF13231.6 EDO18479.1 - 0.00051 20.3 17.5 0.00051 20.3 17.5 3.5 3 1 1 4 4 3 1 Dolichyl-phosphate-mannose-protein mannosyltransferase Pex14_N PF04695.13 EDO18479.1 - 0.002 18.8 60.9 0.019 15.6 16.1 4.9 5 0 0 5 5 5 3 Peroxisomal membrane anchor protein (Pex14p) conserved region HTH_21 PF13276.6 EDO18479.1 - 0.0045 17.1 2.9 44 4.3 0.0 4.7 5 0 0 5 5 5 0 HTH-like domain zf-CCHC_5 PF14787.6 EDO18479.1 - 0.0075 16.0 0.1 58 3.5 0.0 4.2 4 0 0 4 4 4 0 GAG-polyprotein viral zinc-finger Intron_maturas2 PF01348.21 EDO18479.1 - 0.12 12.3 0.0 64 3.5 0.0 3.3 3 0 0 3 3 3 0 Type II intron maturase Transport_MerF PF11431.8 EDO18479.1 - 0.14 12.1 0.6 0.4 10.6 0.6 1.7 1 0 0 1 1 1 0 Membrane transport protein MerF DUF3662 PF12401.8 EDO18479.1 - 0.36 11.2 3.9 84 3.6 0.0 3.9 4 0 0 4 4 4 0 Protein of unknown function (DUF2662) Acp26Ab PF05777.12 EDO18479.1 - 0.38 11.4 3.4 57 4.5 0.1 3.7 3 0 0 3 3 3 0 Drosophila accessory gland-specific peptide 26Ab (Acp26Ab) FtsQ PF03799.15 EDO18479.1 - 3.1 8.6 4.8 1.5e+02 3.2 0.1 4.3 4 1 1 5 5 5 0 Cell division protein FtsQ RPN6_N PF18055.1 EDO18480.1 - 1.8e-35 121.8 3.4 1.8e-35 121.8 3.4 3.0 3 1 0 3 3 3 1 26S proteasome regulatory subunit RPN6 N-terminal domain PCI PF01399.27 EDO18480.1 - 1.8e-17 63.8 0.1 1.8e-17 63.8 0.1 2.6 4 1 0 4 4 4 1 PCI domain RPN6_C_helix PF18503.1 EDO18480.1 - 6.2e-10 38.6 1.6 1.9e-09 37.1 0.7 2.4 2 0 0 2 2 2 1 26S proteasome subunit RPN6 C-terminal helix domain TPR_12 PF13424.6 EDO18480.1 - 0.00018 21.8 2.8 0.014 15.7 0.3 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_15 PF13429.6 EDO18480.1 - 0.0042 16.3 2.7 0.0063 15.8 0.6 2.0 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.6 EDO18480.1 - 0.014 16.0 0.2 0.6 10.8 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat DDRGK PF09756.9 EDO18480.1 - 0.06 12.9 2.1 0.07 12.7 0.1 2.2 2 1 1 3 3 3 0 DDRGK domain GNVR PF13807.6 EDO18480.1 - 0.25 11.3 0.9 1.7 8.7 0.3 2.5 2 0 0 2 2 2 0 G-rich domain on putative tyrosine kinase PNK3P PF08645.11 EDO18481.1 - 5.2e-44 149.8 0.2 6e-44 149.6 0.2 1.0 1 0 0 1 1 1 1 Polynucleotide kinase 3 phosphatase dCache_2 PF08269.11 EDO18481.1 - 0.032 13.4 0.1 0.19 10.8 0.0 2.0 1 1 1 2 2 2 0 Cache domain Cytochrome_P460 PF16694.5 EDO18481.1 - 0.038 14.3 0.1 3.7 7.9 0.0 2.4 2 0 0 2 2 2 0 Cytochrome P460 Fe_dep_repress PF01325.19 EDO18481.1 - 0.082 13.1 0.2 6.4 7.1 0.2 2.3 2 0 0 2 2 2 0 Iron dependent repressor, N-terminal DNA binding domain zf-met PF12874.7 EDO18482.1 - 1.7e-07 31.4 2.4 3.4e-07 30.4 2.4 1.5 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EDO18482.1 - 4.4e-06 26.8 3.4 1.1e-05 25.6 3.4 1.7 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-C2H2_3 PF13878.6 EDO18482.1 - 0.026 14.4 1.0 0.87 9.5 0.2 2.4 2 0 0 2 2 2 0 zinc-finger of acetyl-transferase ESCO zf-C2H2_4 PF13894.6 EDO18482.1 - 0.034 15.0 0.8 0.081 13.8 0.8 1.7 1 0 0 1 1 1 0 C2H2-type zinc finger zf-C2H2_2 PF12756.7 EDO18482.1 - 0.042 14.2 0.3 0.071 13.4 0.3 1.4 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) zf-C2H2 PF00096.26 EDO18482.1 - 0.057 13.9 2.2 0.11 13.0 2.2 1.5 1 0 0 1 1 1 0 Zinc finger, C2H2 type SNRNP27 PF08648.12 EDO18482.1 - 0.21 11.7 1.2 13 5.9 0.1 2.4 2 0 0 2 2 2 0 U4/U6.U5 small nuclear ribonucleoproteins DUF848 PF05852.11 EDO18483.1 - 0.013 15.6 9.9 0.013 15.6 9.9 2.8 1 1 2 3 3 3 0 Gammaherpesvirus protein of unknown function (DUF848) DUF1664 PF07889.12 EDO18483.1 - 0.014 15.4 8.7 0.014 15.4 8.7 2.8 2 1 0 3 3 3 0 Protein of unknown function (DUF1664) SlyX PF04102.12 EDO18483.1 - 0.043 14.4 4.9 0.043 14.4 4.9 4.4 3 2 1 4 4 4 0 SlyX Spc29 PF17082.5 EDO18483.1 - 8 6.2 23.9 0.35 10.7 16.6 2.4 2 1 0 2 2 2 0 Spindle Pole Component 29 ArsA_ATPase PF02374.15 EDO18484.1 - 1.3e-116 389.1 0.0 1.5e-116 388.9 0.0 1.0 1 0 0 1 1 1 1 Anion-transporting ATPase AAA_31 PF13614.6 EDO18484.1 - 7.4e-11 42.3 0.5 8.9e-10 38.8 0.0 2.5 2 1 0 2 2 2 1 AAA domain CbiA PF01656.23 EDO18484.1 - 3.4e-08 33.6 0.0 8.3e-08 32.3 0.0 1.7 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain Fer4_NifH PF00142.18 EDO18484.1 - 0.0018 17.8 0.0 0.0035 16.8 0.0 1.4 1 0 0 1 1 1 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family ParA PF10609.9 EDO18484.1 - 0.003 17.1 1.2 0.013 15.0 0.5 2.3 2 1 1 3 3 3 1 NUBPL iron-transfer P-loop NTPase SRP54 PF00448.22 EDO18484.1 - 0.03 13.9 0.0 0.65 9.6 0.0 2.4 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_25 PF13481.6 EDO18484.1 - 0.038 13.6 0.0 0.078 12.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 EDO18484.1 - 0.063 13.0 0.2 0.66 9.7 0.0 2.5 2 1 0 2 2 2 0 AAA domain NACHT PF05729.12 EDO18484.1 - 0.066 13.1 0.1 0.28 11.1 0.0 1.9 2 0 0 2 2 2 0 NACHT domain PhoH PF02562.16 EDO18484.1 - 0.15 11.5 0.0 0.3 10.5 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein Cpn60_TCP1 PF00118.24 EDO18485.1 - 2.3e-153 511.4 5.9 2.6e-153 511.2 5.9 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Nitro_FeMo-Co PF02579.17 EDO18485.1 - 0.0086 16.4 0.0 0.13 12.6 0.0 2.6 2 0 0 2 2 2 1 Dinitrogenase iron-molybdenum cofactor PUF PF00806.19 EDO18486.1 - 5.1e-31 104.6 6.5 3.9e-05 23.1 0.0 8.3 8 0 0 8 8 8 7 Pumilio-family RNA binding repeat FANCI_S1-cap PF14674.6 EDO18486.1 - 0.052 13.6 0.8 0.35 11.0 0.0 2.6 2 0 0 2 2 2 0 FANCI solenoid 1 cap TetR_C_8 PF14278.6 EDO18486.1 - 2 8.6 7.4 7 6.8 0.4 4.3 4 0 0 4 4 4 0 Transcriptional regulator C-terminal region DUF3294 PF07957.11 EDO18487.1 - 5.5e-93 310.6 3.6 6.1e-93 310.4 3.6 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3294) LTV PF04180.14 EDO18488.1 - 2.7e-109 366.4 37.3 3.3e-109 366.1 37.3 1.0 1 0 0 1 1 1 1 Low temperature viability protein Chordopox_A33R PF05966.12 EDO18488.1 - 0.056 12.7 0.0 1.8 7.8 0.0 2.3 2 0 0 2 2 2 0 Chordopoxvirus A33R protein RNA_pol_Rbc25 PF08292.12 EDO18489.1 - 7.6e-52 174.9 0.3 1e-51 174.5 0.3 1.2 1 0 0 1 1 1 1 RNA polymerase III subunit Rpc25 SHS2_Rpb7-N PF03876.17 EDO18489.1 - 2.7e-20 72.5 0.0 4.1e-20 71.9 0.0 1.3 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 S1 PF00575.23 EDO18489.1 - 0.004 17.5 0.0 0.0086 16.4 0.0 1.6 1 1 0 1 1 1 1 S1 RNA binding domain AAA PF00004.29 EDO18490.1 - 3.2e-40 137.6 0.0 6.3e-40 136.7 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EDO18490.1 - 1e-06 28.4 0.0 2.8e-06 27.0 0.0 1.7 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 EDO18490.1 - 6.3e-05 23.0 0.0 0.00021 21.3 0.0 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EDO18490.1 - 8.6e-05 22.8 0.0 0.003 17.8 0.0 2.3 1 1 1 2 2 2 1 AAA domain AAA_16 PF13191.6 EDO18490.1 - 0.00019 21.8 0.1 0.0036 17.7 0.0 2.3 1 1 1 2 2 2 1 AAA ATPase domain AAA_2 PF07724.14 EDO18490.1 - 0.00036 20.7 0.0 0.00081 19.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) DUF815 PF05673.13 EDO18490.1 - 0.00091 18.5 0.0 0.0016 17.7 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) RuvB_N PF05496.12 EDO18490.1 - 0.0049 16.6 0.0 0.0091 15.8 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_28 PF13521.6 EDO18490.1 - 0.013 15.7 0.0 0.023 15.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 EDO18490.1 - 0.022 15.3 0.1 0.079 13.5 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 EDO18490.1 - 0.029 14.1 0.1 0.091 12.5 0.0 1.9 2 1 0 2 2 2 0 AAA domain AAA_33 PF13671.6 EDO18490.1 - 0.03 14.5 0.0 0.057 13.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EDO18490.1 - 0.039 14.3 0.0 0.087 13.2 0.0 1.6 1 0 0 1 1 1 0 RNA helicase AAA_7 PF12775.7 EDO18490.1 - 0.039 13.5 0.0 0.091 12.3 0.0 1.6 1 1 0 1 1 1 0 P-loop containing dynein motor region TIP49 PF06068.13 EDO18490.1 - 0.044 13.0 0.0 0.1 11.8 0.0 1.5 2 0 0 2 2 2 0 TIP49 P-loop domain ATPase_2 PF01637.18 EDO18490.1 - 0.048 13.6 0.6 5.7 6.8 0.0 2.6 2 1 1 3 3 3 0 ATPase domain predominantly from Archaea AAA_3 PF07726.11 EDO18490.1 - 0.049 13.5 0.0 0.092 12.6 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.21 EDO18490.1 - 0.056 12.8 0.0 0.13 11.6 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 EDO18490.1 - 0.11 12.3 0.0 0.21 11.3 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein Aa_trans PF01490.18 EDO18491.1 - 2.1e-93 313.2 35.4 2.6e-93 313.0 35.4 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 EDO18491.1 - 0.0003 20.0 12.0 0.0003 20.0 12.0 2.6 2 1 1 3 3 3 1 Tryptophan/tyrosine permease family DBR1 PF05011.13 EDO18492.1 - 1.1e-09 38.8 0.0 2.2e-09 37.9 0.0 1.5 1 0 0 1 1 1 1 Lariat debranching enzyme, C-terminal domain Metallophos PF00149.28 EDO18492.1 - 1.6e-09 38.6 2.1 1.6e-09 38.6 2.1 1.7 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase DPM2 PF07297.12 EDO18494.1 - 2.6e-10 40.5 8.7 2.7e-10 40.4 8.7 1.0 1 0 0 1 1 1 1 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) PIG-P PF08510.12 EDO18494.1 - 0.04 13.8 8.4 0.043 13.7 8.4 1.0 1 0 0 1 1 1 0 PIG-P SRPRB PF09439.10 EDO18495.1 - 3.5e-62 209.0 1.9 4.6e-62 208.7 1.9 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Arf PF00025.21 EDO18495.1 - 1.8e-09 37.3 0.1 2.8e-09 36.7 0.1 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EDO18495.1 - 1.4e-07 31.6 0.0 2.5e-07 30.7 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EDO18495.1 - 2.3e-05 24.0 0.1 6.6e-05 22.5 0.0 1.8 1 1 1 2 2 2 1 Ferrous iron transport protein B ATPase_2 PF01637.18 EDO18495.1 - 0.00058 19.8 0.4 0.041 13.8 0.4 2.3 1 1 0 1 1 1 1 ATPase domain predominantly from Archaea TPM_phosphatase PF04536.14 EDO18495.1 - 0.0047 17.1 0.1 0.0086 16.2 0.1 1.5 1 1 0 1 1 1 1 TPM domain ATP_bind_1 PF03029.17 EDO18495.1 - 0.025 14.4 1.0 0.062 13.1 0.4 1.8 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein MobB PF03205.14 EDO18495.1 - 0.046 13.6 0.2 2.5 8.0 0.0 2.3 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B Rsm22 PF09243.10 EDO18496.1 - 9.1e-26 90.7 0.3 5.9e-10 38.9 0.0 4.1 3 1 0 3 3 3 3 Mitochondrial small ribosomal subunit Rsm22 Ribosomal_S27e PF01667.17 EDO18497.1 - 3e-30 103.7 2.8 3.9e-30 103.3 2.8 1.2 1 0 0 1 1 1 1 Ribosomal protein S27 IBR PF01485.21 EDO18497.1 - 0.0098 16.1 0.8 0.011 15.9 0.8 1.2 1 0 0 1 1 1 1 IBR domain, a half RING-finger domain TF_Zn_Ribbon PF08271.12 EDO18497.1 - 0.023 14.2 4.2 0.034 13.6 4.2 1.2 1 0 0 1 1 1 0 TFIIB zinc-binding zf-ACC PF17848.1 EDO18497.1 - 3.4 7.8 6.4 19 5.5 0.2 2.2 2 0 0 2 2 2 0 Acetyl-coA carboxylase zinc finger domain Peptidase_M16_C PF05193.21 EDO18498.1 - 3.9e-47 160.6 0.0 2e-45 155.1 0.0 2.3 2 0 0 2 2 2 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 EDO18498.1 - 1e-41 142.4 0.0 4.1e-41 140.4 0.0 1.9 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) GHMP_kinases_N PF00288.26 EDO18499.1 - 3.9e-10 39.8 0.0 7.3e-10 38.9 0.0 1.5 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 EDO18499.1 - 9.2e-05 22.7 0.0 0.00024 21.4 0.0 1.7 1 0 0 1 1 1 1 GHMP kinases C terminal ATP-synt_C PF00137.21 EDO18500.1 - 4.4e-28 97.4 33.2 6.5e-17 61.6 13.4 2.9 3 0 0 3 3 3 2 ATP synthase subunit C DUF3671 PF12420.8 EDO18500.1 - 1.6 8.8 7.9 0.58 10.3 0.3 3.0 3 0 0 3 3 3 0 Protein of unknown function BP28CT PF08146.12 EDO18501.1 - 6.3e-36 123.6 6.0 1.1e-35 122.8 3.5 3.0 2 0 0 2 2 2 1 BP28CT (NUC211) domain U3snoRNP10 PF12397.8 EDO18501.1 - 1.3e-18 67.4 4.2 1.3e-18 67.4 4.2 4.5 4 0 0 4 4 4 1 U3 small nucleolar RNA-associated protein 10 HEAT_2 PF13646.6 EDO18501.1 - 2.6e-07 30.9 0.1 0.23 11.9 0.0 5.5 5 0 0 5 5 5 2 HEAT repeats HEAT PF02985.22 EDO18501.1 - 0.0045 17.1 0.4 1.7 9.1 0.1 4.0 3 0 0 3 3 3 1 HEAT repeat UME PF08064.13 EDO18501.1 - 0.043 13.7 0.2 2.1 8.3 0.0 4.0 3 0 0 3 3 3 0 UME (NUC010) domain UNC-50 PF05216.13 EDO18502.1 - 6.3e-90 300.6 24.4 7e-90 300.4 24.4 1.0 1 0 0 1 1 1 1 UNC-50 family Mito_carr PF00153.27 EDO18503.1 - 3.7e-58 193.5 2.8 6.1e-20 71.0 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 EDO18503.1 - 0.044 12.9 0.1 0.11 11.6 0.0 1.7 2 1 0 2 2 2 0 Gammaproteobacterial serine protease PAP2 PF01569.21 EDO18504.1 - 8.7e-17 61.2 1.5 2.1e-16 59.9 1.5 1.6 1 0 0 1 1 1 1 PAP2 superfamily PAP2_3 PF14378.6 EDO18504.1 - 0.0046 16.7 1.3 0.012 15.3 1.3 1.7 1 0 0 1 1 1 1 PAP2 superfamily Fer4_5 PF12801.7 EDO18504.1 - 0.042 13.8 0.9 0.19 11.7 0.9 2.1 1 0 0 1 1 1 0 4Fe-4S binding domain tRNA_U5-meth_tr PF05958.11 EDO18505.1 - 1.4e-21 76.9 0.1 1.4e-20 73.7 0.1 2.1 1 1 0 1 1 1 1 tRNA (Uracil-5-)-methyltransferase TRAM PF01938.20 EDO18505.1 - 7.1e-11 41.9 0.1 1.3e-10 41.1 0.1 1.5 1 0 0 1 1 1 1 TRAM domain Methyltransf_31 PF13847.6 EDO18505.1 - 7.1e-09 35.6 0.0 1.6e-08 34.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDO18505.1 - 2.4e-06 28.2 0.0 5.8e-06 26.9 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 EDO18505.1 - 1.2e-05 24.9 0.0 2.5e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_15 PF09445.10 EDO18505.1 - 3.2e-05 23.6 0.1 9.6e-05 22.0 0.1 1.8 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Cons_hypoth95 PF03602.15 EDO18505.1 - 7.6e-05 22.4 0.1 0.00022 20.9 0.0 1.8 2 0 0 2 2 2 1 Conserved hypothetical protein 95 Ubie_methyltran PF01209.18 EDO18505.1 - 0.00013 21.4 0.1 0.003 16.9 0.0 2.2 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family MTS PF05175.14 EDO18505.1 - 0.0016 18.0 0.0 0.0036 16.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_11 PF08241.12 EDO18505.1 - 0.0051 17.4 0.0 0.011 16.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 EDO18505.1 - 0.011 15.2 0.1 0.09 12.2 0.0 2.2 2 0 0 2 2 2 0 Putative methyltransferase Ribosomal_S21e PF01249.18 EDO18506.1 - 5.3e-34 116.2 0.1 5.9e-34 116.0 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S21e VCH_CASS14 PF18315.1 EDO18506.1 - 0.059 13.4 0.0 0.14 12.3 0.0 1.6 1 1 1 2 2 2 0 Integron cassette protein VCH_CASS1 chain Glyco_transf_8 PF01501.20 EDO18507.1 - 1.3e-28 100.2 0.6 3e-28 99.1 0.6 1.6 1 0 0 1 1 1 1 Glycosyl transferase family 8 Glyco_transf_15 PF01793.16 EDO18508.1 - 5.7e-105 351.2 15.8 7.2e-105 350.8 15.8 1.1 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase Pkinase PF00069.25 EDO18509.1 - 2e-49 168.3 2.1 5.8e-49 166.8 0.2 2.3 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO18509.1 - 9.6e-20 70.9 0.0 2.2e-19 69.8 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EDO18509.1 - 0.002 18.1 0.0 0.0041 17.1 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.22 EDO18509.1 - 0.0069 16.0 0.0 0.021 14.5 0.0 1.7 1 0 0 1 1 1 1 RIO1 family YrbL-PhoP_reg PF10707.9 EDO18509.1 - 0.27 10.7 2.2 0.38 10.3 0.0 2.2 2 0 0 2 2 2 0 PhoP regulatory network protein YrbL Tim17 PF02466.19 EDO18510.1 - 1.6e-30 105.7 7.4 2.1e-30 105.4 7.4 1.1 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family DUF87 PF01935.17 EDO18511.1 - 0.055 13.6 1.8 0.14 12.2 1.8 1.6 1 0 0 1 1 1 0 Helicase HerA, central domain ECD PF18432.1 EDO18511.1 - 0.093 12.7 0.2 0.43 10.6 0.0 2.2 2 0 0 2 2 2 0 Extracellular Cadherin domain HIM1 PF08732.10 EDO18511.1 - 0.098 12.2 0.1 0.21 11.1 0.1 1.6 1 0 0 1 1 1 0 HIM1 EF-G-binding_N PF07299.11 EDO18512.1 - 0.5 10.9 6.0 2.2 8.8 0.1 3.7 4 0 0 4 4 4 0 Elongation factor G-binding protein, N-terminal HrcA PF01628.21 EDO18512.1 - 0.63 9.9 6.0 0.28 11.1 1.9 2.2 2 0 0 2 2 2 0 HrcA protein C terminal domain RNA_polI_A34 PF08208.11 EDO18513.1 - 3.1e-26 92.7 15.3 4.3e-26 92.3 15.3 1.2 1 0 0 1 1 1 1 DNA-directed RNA polymerase I subunit RPA34.5 Las1 PF04031.13 EDO18514.1 - 6.2e-50 169.3 0.8 1.5e-49 168.0 0.3 2.0 2 0 0 2 2 2 1 Las1-like Sdh5 PF03937.16 EDO18514.1 - 0.011 15.7 1.0 4.8 7.2 0.0 2.8 2 0 0 2 2 2 0 Flavinator of succinate dehydrogenase MitMem_reg PF13012.6 EDO18514.1 - 0.16 12.4 0.1 0.16 12.4 0.1 2.8 2 1 1 3 3 3 0 Maintenance of mitochondrial structure and function ATP-synt_F6 PF05511.11 EDO18514.1 - 0.69 10.4 3.8 3 8.3 1.0 2.9 3 0 0 3 3 3 0 Mitochondrial ATP synthase coupling factor 6 Zn_clus PF00172.18 EDO18515.1 - 5.6e-08 32.8 10.5 1.2e-07 31.8 10.5 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EDO18515.1 - 0.0076 15.3 0.3 0.02 14.0 0.1 1.8 2 0 0 2 2 2 1 Fungal specific transcription factor domain NAD_binding_5 PF07994.12 EDO18516.1 - 6.4e-141 469.4 0.1 7.3e-141 469.2 0.1 1.0 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase Inos-1-P_synth PF01658.17 EDO18516.1 - 3.5e-42 143.1 0.6 6.9e-42 142.1 0.6 1.5 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase DUF1706 PF08020.11 EDO18516.1 - 0.021 14.8 0.2 0.034 14.1 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1706) Phi29_Phage_SSB PF17427.2 EDO18516.1 - 0.027 14.7 0.1 0.059 13.6 0.1 1.5 1 0 0 1 1 1 0 Phage Single-stranded DNA-binding protein Vps35 PF03635.17 EDO18517.1 - 3.2e-199 664.0 40.1 3.7e-199 663.8 40.1 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 35 6PF2K PF01591.18 EDO18518.1 - 5.9e-83 277.6 2.1 8.1e-83 277.1 2.1 1.2 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 EDO18518.1 - 1.2e-37 129.5 0.0 1.7e-37 129.0 0.0 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.6 EDO18518.1 - 6.4e-06 26.4 0.0 1.7e-05 25.0 0.0 1.7 1 1 0 1 1 1 1 AAA domain PH_10 PF15411.6 EDO18519.1 - 0.026 14.8 0.0 0.083 13.2 0.0 1.9 1 0 0 1 1 1 0 Pleckstrin homology domain zf-RING_2 PF13639.6 EDO18519.1 - 0.056 13.8 10.2 0.12 12.7 10.2 1.6 1 0 0 1 1 1 0 Ring finger domain PIR PF00399.19 EDO18520.1 - 1.1e-10 40.7 16.7 1.4e-08 34.1 5.3 3.7 5 0 0 5 5 5 2 Yeast PIR protein repeat PIR PF00399.19 EDO18521.1 - 2.4e-83 272.2 146.6 9.6e-09 34.6 7.6 10.6 10 0 0 10 10 10 10 Yeast PIR protein repeat DUF4097 PF13349.6 EDO18521.1 - 7.2 5.9 32.0 2.6e+03 -2.5 32.0 2.2 1 1 0 1 1 1 0 Putative adhesin FAM24 PF15193.6 EDO18522.1 - 0.0061 17.3 1.0 0.015 16.0 1.0 1.7 1 1 0 1 1 1 1 FAM24 family DnaJ PF00226.31 EDO18523.1 - 7e-17 61.3 0.6 7e-17 61.3 0.6 2.5 3 0 0 3 3 3 1 DnaJ domain MFS_1 PF07690.16 EDO18524.1 - 2.4e-22 79.3 14.4 2.4e-22 79.3 14.4 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily Ac76 PF05814.11 EDO18524.1 - 0.016 15.2 1.3 0.14 12.2 0.0 3.2 2 1 0 2 2 2 0 Orf76 (Ac76) Pkinase PF00069.25 EDO18525.1 - 1.2e-41 142.8 0.0 3.1e-41 141.5 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO18525.1 - 4.7e-19 68.7 0.0 9.3e-19 67.7 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EDO18525.1 - 0.028 13.8 0.1 0.051 12.9 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EDO18525.1 - 0.089 12.1 0.0 0.15 11.4 0.0 1.3 1 0 0 1 1 1 0 Kinase-like APH PF01636.23 EDO18525.1 - 0.18 11.7 0.1 0.3 11.0 0.1 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase PF00069.25 EDO18526.1 - 1.7e-37 129.2 0.1 1.6e-25 90.0 0.4 2.4 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EDO18526.1 - 1.8e-21 76.6 0.1 1.2e-17 64.0 0.1 2.4 2 1 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 EDO18526.1 - 0.029 13.7 0.0 3 7.1 0.0 2.3 2 0 0 2 2 2 0 Kinase-like Calycin_like PF13944.6 EDO18526.1 - 0.13 12.5 0.4 1.8 8.9 0.0 2.3 2 0 0 2 2 2 0 Calycin-like beta-barrel domain APH PF01636.23 EDO18526.1 - 0.15 12.0 0.0 0.24 11.3 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Ebp2 PF05890.12 EDO18527.1 - 7.8e-89 297.8 25.9 7.8e-89 297.8 25.9 3.0 1 1 2 3 3 3 1 Eukaryotic rRNA processing protein EBP2 GTP_EFTU PF00009.27 EDO18528.1 - 1.1e-35 122.9 0.0 1.7e-35 122.3 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_C PF00679.24 EDO18528.1 - 2e-17 63.0 0.0 5.6e-17 61.6 0.0 1.8 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_IV PF03764.18 EDO18528.1 - 1.7e-11 44.0 0.0 3.5e-11 42.9 0.0 1.5 1 0 0 1 1 1 1 Elongation factor G, domain IV EFTUD2 PF16004.5 EDO18528.1 - 4.6e-09 36.9 7.0 0.00069 20.2 1.4 2.4 1 1 1 2 2 2 2 116 kDa U5 small nuclear ribonucleoprotein component N-terminus EFG_II PF14492.6 EDO18528.1 - 2.4e-07 30.7 0.0 4.9e-07 29.7 0.0 1.6 1 0 0 1 1 1 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.25 EDO18528.1 - 8.8e-05 22.8 0.0 0.00027 21.3 0.0 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EDO18528.1 - 0.0088 16.1 0.6 0.021 14.9 0.2 1.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase SRPRB PF09439.10 EDO18528.1 - 0.0092 15.4 0.2 0.15 11.5 0.2 2.4 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 EDO18528.1 - 0.013 15.2 0.3 0.31 10.6 0.3 2.5 1 1 0 1 1 1 0 Ras family Roc PF08477.13 EDO18528.1 - 0.021 15.1 0.1 1.4 9.1 0.1 2.5 1 1 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase DUF3440 PF11922.8 EDO18528.1 - 0.11 12.2 0.0 0.28 10.9 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3440) FtsK_SpoIIIE PF01580.18 EDO18528.1 - 0.21 10.9 0.0 0.49 9.7 0.0 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family Zip PF02535.22 EDO18529.1 - 3.6e-24 85.6 11.3 7.9e-23 81.2 11.3 2.1 1 1 0 1 1 1 1 ZIP Zinc transporter DUF3899 PF13038.6 EDO18529.1 - 0.0092 16.5 0.0 0.53 10.8 0.0 3.1 2 0 0 2 2 2 1 Domain of unknown function (DUF3899) DUF1761 PF08570.10 EDO18529.1 - 0.02 15.1 2.0 0.029 14.6 0.4 2.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1761) DUF3937 PF13073.6 EDO18529.1 - 0.11 12.6 0.3 4.2 7.6 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3937) SRI PF08236.11 EDO18530.1 - 9.5e-26 89.8 5.4 9.5e-26 89.8 5.4 2.5 2 0 0 2 2 2 1 SRI (Set2 Rpb1 interacting) domain SET PF00856.28 EDO18530.1 - 7.4e-19 68.7 0.8 7.4e-19 68.7 0.8 4.5 3 2 0 3 3 3 1 SET domain WW_1 PF18507.1 EDO18530.1 - 3.9e-18 64.8 1.7 7.8e-18 63.8 1.7 1.5 1 0 0 1 1 1 1 WW domain AWS PF17907.1 EDO18530.1 - 2.8e-14 52.9 10.3 2.8e-14 52.9 10.3 1.9 2 0 0 2 2 2 1 AWS domain Mem_trans PF03547.18 EDO18531.1 - 0.12 10.8 0.6 0.16 10.3 0.6 1.2 1 0 0 1 1 1 0 Membrane transport protein DUF2401 PF10287.9 EDO18532.1 - 1.6e-81 273.2 1.3 2.2e-81 272.8 1.3 1.2 1 0 0 1 1 1 1 Putative TOS1-like glycosyl hydrolase (DUF2401) DUF2403 PF10290.9 EDO18532.1 - 7.5e-23 80.7 0.1 1.5e-22 79.8 0.1 1.5 1 0 0 1 1 1 1 Glycine-rich protein domain (DUF2403) STE3 PF02076.15 EDO18533.1 - 1.5e-86 290.2 20.8 1.8e-86 290.0 20.8 1.1 1 0 0 1 1 1 1 Pheromone A receptor KRE9 PF05390.11 EDO18534.1 - 1.2e-45 154.4 9.2 1.2e-45 154.4 9.2 1.8 2 0 0 2 2 2 1 Yeast cell wall synthesis protein KRE9/KNH1 GPI-anchored PF10342.9 EDO18534.1 - 5.8e-08 33.4 1.0 5.8e-08 33.4 1.0 2.7 2 1 1 3 3 3 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family Arylsulfotran_N PF17425.2 EDO18534.1 - 0.0034 17.4 0.6 0.0034 17.4 0.6 2.3 2 1 0 2 2 2 1 Arylsulfotransferase Ig-like domain Herpes_UL36 PF03586.13 EDO18534.1 - 0.037 13.3 0.3 0.052 12.8 0.3 1.1 1 0 0 1 1 1 0 Herpesvirus UL36 tegument protein SWIRM PF04433.17 EDO18535.1 - 7e-29 100.0 0.2 2.1e-28 98.5 0.2 1.9 1 0 0 1 1 1 1 SWIRM domain SWIRM-assoc_1 PF16495.5 EDO18535.1 - 9e-23 80.1 5.6 2.6e-22 78.6 5.6 1.9 1 0 0 1 1 1 1 SWIRM-associated region 1 Myb_DNA-binding PF00249.31 EDO18535.1 - 2.1e-11 43.8 0.1 5.1e-11 42.6 0.1 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EDO18535.1 - 6.5e-07 29.5 0.2 2.6e-06 27.6 0.0 2.2 2 0 0 2 2 2 1 Myb-like DNA-binding domain DUF3781 PF12636.7 EDO18535.1 - 3.8 7.4 5.2 2.2 8.2 0.4 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF3781) ATP12 PF07542.11 EDO18536.1 - 3.1e-33 114.6 0.0 6.6e-33 113.5 0.0 1.6 2 0 0 2 2 2 1 ATP12 chaperone protein Gon7 PF08738.10 EDO18538.1 - 1.1e-42 144.5 1.0 1.3e-42 144.2 1.0 1.1 1 0 0 1 1 1 1 Gon7 family FAM76 PF16046.5 EDO18538.1 - 0.017 14.5 0.3 0.018 14.4 0.3 1.0 1 0 0 1 1 1 0 FAM76 protein COG2 PF06148.11 EDO18538.1 - 0.022 14.9 0.3 0.031 14.4 0.3 1.2 1 0 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 NUC153 PF08159.12 EDO18538.1 - 0.032 14.0 0.0 0.057 13.2 0.0 1.5 1 0 0 1 1 1 0 NUC153 domain muHD PF10291.9 EDO18539.1 - 3.4e-77 259.4 0.3 5.2e-77 258.9 0.3 1.3 1 0 0 1 1 1 1 Muniscin C-terminal mu homology domain FCH PF00611.23 EDO18540.1 - 0.001 19.3 0.7 0.0018 18.5 0.7 1.4 1 0 0 1 1 1 1 Fes/CIP4, and EFC/F-BAR homology domain Pkinase PF00069.25 EDO18541.1 - 7.3e-48 163.2 0.0 1.4e-47 162.3 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO18541.1 - 6.1e-29 101.1 0.0 1.1e-28 100.2 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase DUF4299 PF14132.6 EDO18541.1 - 3.5e-05 23.4 1.7 6.5e-05 22.5 1.7 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4299) Kinase-like PF14531.6 EDO18541.1 - 0.028 13.8 0.0 2.8 7.2 0.0 2.3 2 0 0 2 2 2 0 Kinase-like TetR_C_8 PF14278.6 EDO18541.1 - 0.074 13.2 0.5 0.3 11.2 0.5 2.1 1 0 0 1 1 1 0 Transcriptional regulator C-terminal region Ribosomal_L39 PF00832.20 EDO18542.1 - 1.3e-22 79.1 12.9 1.5e-22 78.9 12.9 1.1 1 0 0 1 1 1 1 Ribosomal L39 protein Ribosomal_S8 PF00410.19 EDO18543.1 - 1.1e-23 83.6 0.1 1.8e-23 82.9 0.1 1.4 1 1 0 1 1 1 1 Ribosomal protein S8 Ribosomal_S11 PF00411.19 EDO18544.1 - 1.1e-30 106.2 1.6 1.3e-30 106.0 1.6 1.1 1 0 0 1 1 1 1 Ribosomal protein S11 Myb_DNA-binding PF00249.31 EDO18545.1 - 1.6e-17 63.4 0.0 5.6e-08 32.9 0.0 2.6 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EDO18545.1 - 1.4e-07 31.7 2.6 0.023 15.0 0.1 3.7 3 0 0 3 3 3 2 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 EDO18545.1 - 0.044 13.7 0.1 0.044 13.7 0.1 3.9 4 0 0 4 4 4 0 Myb DNA-binding like ELO PF01151.18 EDO18546.1 - 1.7e-62 211.2 27.6 2.1e-62 210.9 27.6 1.1 1 0 0 1 1 1 1 GNS1/SUR4 family RNase_PH PF01138.21 EDO18547.1 - 4.1e-22 79.1 0.0 1e-21 77.8 0.0 1.7 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 PfkB PF00294.24 EDO18548.1 - 8.6e-44 150.0 6.4 5.8e-43 147.3 6.4 2.0 1 1 0 1 1 1 1 pfkB family carbohydrate kinase MoCF_biosynth PF00994.24 EDO18548.1 - 0.0012 18.6 0.0 0.0024 17.5 0.0 1.5 1 0 0 1 1 1 1 Probable molybdopterin binding domain Phos_pyr_kin PF08543.12 EDO18548.1 - 0.019 14.3 0.2 0.045 13.1 0.2 1.7 1 1 0 1 1 1 0 Phosphomethylpyrimidine kinase TPK_catalytic PF04263.16 EDO18548.1 - 0.066 13.3 0.8 0.37 10.8 0.1 2.2 2 0 0 2 2 2 0 Thiamin pyrophosphokinase, catalytic domain UCH PF00443.29 EDO18549.1 - 1.4e-76 257.4 1.8 1.4e-76 257.4 1.8 1.8 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EDO18549.1 - 8.1e-16 58.5 5.2 2.9e-07 30.4 0.3 2.8 2 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase DUSP PF06337.12 EDO18549.1 - 3.7e-06 27.5 3.6 1.3e-05 25.7 1.5 3.0 2 0 0 2 2 2 1 DUSP domain USP7_C2 PF14533.6 EDO18549.1 - 0.00023 20.9 0.1 0.00023 20.9 0.1 2.6 3 0 0 3 3 3 1 Ubiquitin-specific protease C-terminal SPX PF03105.19 EDO18550.1 - 2e-47 162.9 30.0 2e-47 162.9 30.0 1.6 2 0 0 2 2 2 1 SPX domain CitMHS PF03600.16 EDO18550.1 - 1.2e-20 74.0 59.8 3.7e-19 69.1 30.1 2.4 2 1 1 3 3 3 2 Citrate transporter Na_sulph_symp PF00939.19 EDO18550.1 - 6e-19 68.4 38.1 8.3e-19 68.0 38.1 1.1 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region Aconitase PF00330.20 EDO18551.1 - 4.4e-145 484.2 0.0 5.5e-145 483.9 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 EDO18551.1 - 2e-42 144.6 0.0 3.5e-42 143.8 0.0 1.4 1 0 0 1 1 1 1 Aconitase C-terminal domain DUF521 PF04412.13 EDO18551.1 - 0.19 10.4 0.0 0.35 9.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF521) RasGEF PF00617.19 EDO18552.1 - 6e-42 143.8 8.2 1.1e-41 143.0 4.2 2.8 2 0 0 2 2 2 1 RasGEF domain RasGEF_N PF00618.20 EDO18552.1 - 1.7e-12 47.5 1.2 1.7e-12 47.5 1.2 3.2 3 0 0 3 3 3 1 RasGEF N-terminal motif SH3_1 PF00018.28 EDO18552.1 - 0.0013 18.2 0.1 0.0028 17.2 0.1 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EDO18552.1 - 0.081 12.8 0.0 0.22 11.4 0.0 1.7 1 0 0 1 1 1 0 Variant SH3 domain CRAL_TRIO_2 PF13716.6 EDO18553.1 - 4.7e-31 107.8 0.5 1.3e-30 106.4 0.5 1.7 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain RhoGAP PF00620.27 EDO18553.1 - 5.2e-10 39.3 1.5 2.1e-09 37.4 0.1 2.7 2 1 0 2 2 2 1 RhoGAP domain Mucin_bdg PF03272.13 EDO18553.1 - 0.085 12.9 0.5 0.2 11.7 0.5 1.6 1 0 0 1 1 1 0 Putative mucin or carbohydrate-binding module LRRFIP PF09738.9 EDO18554.1 - 0.0091 15.5 1.4 0.011 15.2 1.4 1.1 1 0 0 1 1 1 1 LRRFIP family FlxA PF14282.6 EDO18554.1 - 0.064 13.2 1.9 0.12 12.4 1.9 1.4 1 1 0 1 1 1 0 FlxA-like protein DUF4110 PF13422.6 EDO18554.1 - 0.12 12.5 0.1 0.9 9.6 0.1 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4110) Mito_fiss_reg PF05308.11 EDO18554.1 - 0.35 10.9 3.8 4.8 7.2 0.6 2.2 1 1 1 2 2 2 0 Mitochondrial fission regulator DUF5344 PF17279.2 EDO18554.1 - 0.43 11.2 4.7 8.6 7.0 1.5 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5344) HAUS-augmin3 PF14932.6 EDO18555.1 - 0.018 14.7 6.8 0.019 14.6 6.8 1.0 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 DUF5630 PF18632.1 EDO18555.1 - 0.021 14.2 0.9 0.049 12.9 0.9 1.6 1 1 0 1 1 1 0 Family of unknown function (DUF5630) TEX13 PF15186.6 EDO18555.1 - 0.044 13.5 2.6 0.052 13.2 2.6 1.1 1 0 0 1 1 1 0 Testis-expressed sequence 13 protein family SKA2 PF16740.5 EDO18555.1 - 0.046 13.5 6.1 0.048 13.4 6.1 1.0 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 2 PKI PF02827.16 EDO18555.1 - 0.59 10.4 4.2 0.44 10.8 0.8 1.9 1 1 1 2 2 2 0 cAMP-dependent protein kinase inhibitor PRP21_like_P PF12230.8 EDO18556.1 - 7.7e-59 199.2 18.1 7.7e-59 199.2 18.1 1.4 2 0 0 2 2 2 1 Pre-mRNA splicing factor PRP21 like protein Surp PF01805.20 EDO18556.1 - 2.4e-16 59.5 2.6 1.1e-08 34.9 0.2 2.6 2 0 0 2 2 2 2 Surp module DUF2800 PF10926.8 EDO18556.1 - 0.016 14.5 4.0 0.023 14.0 4.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2800) SpoOE-like PF09388.10 EDO18556.1 - 0.051 13.5 0.5 6.4 6.8 0.0 3.5 3 0 0 3 3 3 0 Spo0E like sporulation regulatory protein Sec31 PF11549.8 EDO18557.1 - 5.3e-24 83.9 2.0 5.3e-24 83.9 2.0 2.3 2 0 0 2 2 2 1 Protein transport protein SEC31 SRA1 PF07304.11 EDO18557.1 - 7.3e-05 22.6 3.9 0.00017 21.4 0.0 3.2 3 0 0 3 3 3 1 Steroid receptor RNA activator (SRA1) Sec16_C PF12931.7 EDO18557.1 - 0.00067 19.4 2.9 0.0015 18.2 1.5 2.2 2 0 0 2 2 2 1 Sec23-binding domain of Sec16 Prp18 PF02840.15 EDO18557.1 - 0.001 19.1 1.0 0.001 19.1 1.0 2.8 3 1 0 3 3 3 1 Prp18 domain WD40 PF00400.32 EDO18557.1 - 0.049 14.5 15.1 0.7 10.9 0.1 5.4 4 1 0 4 4 4 0 WD domain, G-beta repeat MmlI PF09448.10 EDO18557.1 - 0.061 13.8 0.0 0.13 12.7 0.0 1.5 1 0 0 1 1 1 0 Methylmuconolactone methyl-isomerase Pro_isomerase PF00160.21 EDO18558.1 - 1.5e-44 152.0 0.2 2.8e-44 151.2 0.1 1.6 2 0 0 2 2 2 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TPR_1 PF00515.28 EDO18558.1 - 0.00018 21.1 2.3 0.00039 20.1 0.1 2.8 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_2 PF07719.17 EDO18558.1 - 0.00019 21.3 0.6 0.0062 16.6 0.1 2.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 EDO18558.1 - 0.0072 16.5 0.4 0.035 14.3 0.1 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.6 EDO18558.1 - 0.0098 16.5 0.1 0.041 14.5 0.1 2.1 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_9 PF13371.6 EDO18558.1 - 0.053 13.7 0.4 0.092 12.9 0.4 1.3 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_16 PF13432.6 EDO18558.1 - 0.079 13.6 0.1 0.22 12.2 0.2 1.7 2 0 0 2 2 2 0 Tetratricopeptide repeat Coatomer_WDAD PF04053.14 EDO18559.1 - 1.3e-129 433.1 3.5 2.4e-129 432.3 3.5 1.4 1 0 0 1 1 1 1 Coatomer WD associated region COPI_C PF06957.11 EDO18559.1 - 7.2e-84 281.9 0.0 1e-83 281.4 0.0 1.1 1 0 0 1 1 1 1 Coatomer (COPI) alpha subunit C-terminus WD40 PF00400.32 EDO18559.1 - 9.4e-40 133.9 14.8 9.3e-08 32.6 0.1 7.6 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDO18559.1 - 2e-12 47.2 0.4 0.0031 17.8 0.0 6.8 5 2 1 7 7 7 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EDO18559.1 - 2.7e-07 29.6 6.7 0.046 12.4 0.1 4.6 3 1 2 5 5 5 3 Nucleoporin Nup120/160 eIF2A PF08662.11 EDO18559.1 - 5.3e-05 23.2 0.1 1.9 8.4 0.0 4.1 3 1 1 4 4 4 2 Eukaryotic translation initiation factor eIF2A ENTH PF01417.20 EDO18559.1 - 0.058 13.4 0.9 0.18 11.8 0.6 1.9 1 1 0 1 1 1 0 ENTH domain DEAD PF00270.29 EDO18560.1 - 2e-45 154.7 0.1 3.2e-45 154.0 0.1 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDO18560.1 - 2.4e-30 105.2 1.8 1.2e-28 99.6 0.5 2.6 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDO18560.1 - 6.1e-06 26.3 0.0 1.4e-05 25.2 0.0 1.6 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Phage_integrase PF00589.22 EDO18560.1 - 0.12 12.1 0.1 0.29 10.9 0.1 1.6 1 0 0 1 1 1 0 Phage integrase family WD40 PF00400.32 EDO18561.1 - 8.8e-20 70.7 13.9 9e-05 23.2 0.1 6.7 6 1 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDO18561.1 - 6e-08 32.9 4.3 0.0085 16.4 0.3 4.0 2 2 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Sel1 PF08238.12 EDO18562.1 - 6.6e-26 90.2 17.1 1.6e-06 28.6 0.6 8.7 9 0 0 9 9 9 5 Sel1 repeat TPR_12 PF13424.6 EDO18562.1 - 0.0012 19.1 0.7 5.1 7.5 0.4 4.6 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.6 EDO18562.1 - 0.0017 18.8 1.9 0.075 13.7 0.1 4.7 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_16 PF13432.6 EDO18562.1 - 0.006 17.2 3.9 0.65 10.7 0.0 4.5 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_1 PF00515.28 EDO18562.1 - 0.0069 16.2 23.8 0.24 11.3 0.2 7.4 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_2 PF07719.17 EDO18562.1 - 0.014 15.5 19.8 0.46 10.7 0.0 7.5 9 0 0 9 9 9 0 Tetratricopeptide repeat TPR_7 PF13176.6 EDO18562.1 - 0.026 14.5 7.3 2.9 8.1 0.0 6.0 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_19 PF14559.6 EDO18562.1 - 0.027 15.0 5.5 10 6.7 0.0 4.5 4 0 0 4 4 4 0 Tetratricopeptide repeat GlgS PF08971.11 EDO18562.1 - 0.12 12.4 0.4 2.5 8.2 0.0 3.0 3 0 0 3 3 3 0 Glycogen synthesis protein ENTH PF01417.20 EDO18563.1 - 1.3e-43 148.0 0.1 1.3e-43 148.0 0.1 2.0 2 0 0 2 2 2 1 ENTH domain DNA_ligase_A_M PF01068.21 EDO18564.1 - 8.3e-64 215.0 0.3 1.3e-63 214.3 0.3 1.3 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 EDO18564.1 - 1.6e-47 162.0 0.1 4.3e-47 160.6 0.1 1.8 2 0 0 2 2 2 1 DNA ligase N terminus DNA_ligase_A_C PF04679.15 EDO18564.1 - 1.8e-24 86.2 0.0 5.4e-24 84.7 0.0 1.9 2 0 0 2 2 2 1 ATP dependent DNA ligase C terminal region RNA_ligase PF09414.10 EDO18564.1 - 5.4e-06 26.8 0.2 1.4e-05 25.5 0.3 1.7 2 0 0 2 2 2 1 RNA ligase DNA_ligase_OB_2 PF14743.6 EDO18564.1 - 0.012 15.6 1.1 3.2 7.8 0.1 2.5 2 0 0 2 2 2 0 DNA ligase OB-like domain EF-hand_like PF09279.11 EDO18564.1 - 0.28 11.7 4.0 5.1 7.7 0.0 4.4 6 0 0 6 6 6 0 Phosphoinositide-specific phospholipase C, efhand-like Pox_Ag35 PF03286.14 EDO18565.1 - 0.0018 18.1 0.0 0.0018 18.1 0.0 1.8 2 0 0 2 2 2 1 Pox virus Ag35 surface protein Response_reg PF00072.24 EDO18566.1 - 6e-27 94.0 1.3 1.8e-26 92.5 1.3 1.9 1 0 0 1 1 1 1 Response regulator receiver domain HATPase_c PF02518.26 EDO18566.1 - 8.5e-27 93.9 0.1 9.7e-20 71.2 0.0 2.8 2 0 0 2 2 2 2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 EDO18566.1 - 1e-13 51.1 1.5 2.1e-13 50.1 0.1 2.3 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain HAMP PF00672.25 EDO18566.1 - 0.0017 18.7 0.0 0.4 11.1 0.0 2.5 2 0 0 2 2 2 2 HAMP domain YabA PF06156.13 EDO18567.1 - 0.011 16.3 3.5 0.011 16.3 3.5 10.2 4 3 5 10 10 10 0 Initiation control protein YabA GIIM PF08388.11 EDO18567.1 - 3.9 7.6 5.0 2.8 8.0 0.1 3.4 3 0 0 3 3 3 0 Group II intron, maturase-specific domain Herpes_UL33 PF03581.13 EDO18567.1 - 5.3 7.5 7.6 5.2 7.5 0.1 4.4 5 1 0 5 5 5 0 Herpesvirus UL33-like protein MbeD_MobD PF04899.12 EDO18567.1 - 9.8 6.4 14.0 14 5.9 1.1 5.7 5 0 0 5 5 5 0 MbeD/MobD like PTPA PF03095.15 EDO18568.1 - 8.7e-106 353.7 0.0 1e-105 353.5 0.0 1.0 1 0 0 1 1 1 1 Phosphotyrosyl phosphate activator (PTPA) protein UCH PF00443.29 EDO18569.1 - 7.5e-52 176.4 2.2 8.5e-52 176.2 2.2 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EDO18569.1 - 1.6e-17 64.1 2.4 3.7e-17 62.9 2.4 1.6 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase CW_binding_1 PF01473.20 EDO18569.1 - 0.015 15.6 1.1 0.054 13.8 1.1 2.0 1 0 0 1 1 1 0 Putative cell wall binding repeat Ribosomal_L37e PF01907.19 EDO18569.1 - 0.063 13.4 1.2 1.1 9.4 0.0 2.5 2 0 0 2 2 2 0 Ribosomal protein L37e Nudix_N_2 PF14803.6 EDO18569.1 - 0.1 12.5 1.1 5.5 7.0 0.1 2.6 2 0 0 2 2 2 0 Nudix N-terminal Rubredoxin_2 PF18073.1 EDO18569.1 - 1.1 9.0 6.2 11 5.9 0.6 2.4 2 0 0 2 2 2 0 Rubredoxin metal binding domain RNA_POL_M_15KD PF02150.16 EDO18569.1 - 8.2 6.4 6.5 0.94 9.4 0.7 2.4 3 0 0 3 3 3 0 RNA polymerases M/15 Kd subunit DUF2009 PF09418.10 EDO18571.1 - 3.1e-207 689.1 1.9 4e-207 688.7 1.9 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2009) zf-B_box PF00643.24 EDO18571.1 - 0.0013 18.9 8.1 0.0023 18.1 8.1 1.4 1 0 0 1 1 1 1 B-box zinc finger CEBP_ZZ PF16366.5 EDO18571.1 - 0.01 16.0 6.1 0.026 14.8 6.1 1.6 1 0 0 1 1 1 0 Cytoplasmic polyadenylation element-binding protein ZZ domain IBR PF01485.21 EDO18571.1 - 0.047 13.9 4.5 0.13 12.5 4.5 1.7 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain YqbF PF14553.6 EDO18571.1 - 0.092 12.6 0.3 0.27 11.1 0.3 1.7 1 0 0 1 1 1 0 YqbF, hypothetical protein domain Lipoprotein_Ltp PF07553.11 EDO18571.1 - 0.24 11.7 1.8 6.7 7.1 0.3 2.8 2 0 0 2 2 2 0 Host cell surface-exposed lipoprotein Fer4_6 PF12837.7 EDO18571.1 - 1.2 9.3 10.0 4.1 7.7 10.0 2.0 1 0 0 1 1 1 0 4Fe-4S binding domain LSM PF01423.22 EDO18572.1 - 1.2e-16 60.2 0.1 1.6e-16 59.8 0.1 1.2 1 0 0 1 1 1 1 LSM domain CAP_GLY PF01302.25 EDO18573.1 - 2e-20 72.6 0.5 3.2e-20 71.9 0.5 1.3 1 0 0 1 1 1 1 CAP-Gly domain Ubiquitin_2 PF14560.6 EDO18573.1 - 1.9e-06 28.2 0.0 3.2e-06 27.5 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-like domain RNA_pol_3_Rpc31 PF11705.8 EDO18574.1 - 4.2e-53 180.9 10.2 5.2e-53 180.6 10.2 1.1 1 0 0 1 1 1 1 DNA-directed RNA polymerase III subunit Rpc31 CNDH2_C PF16858.5 EDO18574.1 - 0.0076 16.2 2.8 0.01 15.8 2.8 1.1 1 0 0 1 1 1 1 Condensin II complex subunit CAP-H2 or CNDH2, C-term THOC2_N PF16134.5 EDO18575.1 - 2.9e-162 541.6 14.5 2.9e-162 541.6 14.5 1.7 2 0 0 2 2 2 1 THO complex subunit 2 N-terminus Tho2 PF11262.8 EDO18575.1 - 1.3e-36 126.3 9.4 3.8e-28 98.5 5.1 4.8 6 0 0 6 6 6 2 Transcription factor/nuclear export subunit protein 2 Thoc2 PF11732.8 EDO18575.1 - 2.6e-22 78.7 0.2 1.1e-21 76.7 0.2 2.2 1 0 0 1 1 1 1 Transcription- and export-related complex subunit PIR PF00399.19 EDO18576.1 - 5.7e-16 57.6 13.8 3.1e-08 33.0 5.6 3.0 2 0 0 2 2 2 2 Yeast PIR protein repeat Nefa_Nip30_N PF10187.9 EDO18577.1 - 5.4e-09 36.4 18.0 1.1e-08 35.4 18.0 1.5 1 0 0 1 1 1 1 N-terminal domain of NEFA-interacting nuclear protein NIP30 NDT80_PhoG PF05224.12 EDO18578.1 - 9.7e-66 221.5 1.3 9.7e-66 221.5 1.3 2.7 4 0 0 4 4 4 1 NDT80 / PhoG like DNA-binding family GNAT_acetyltr_2 PF13718.6 EDO18579.1 - 1.4e-99 332.1 0.0 4.4e-99 330.5 0.0 1.9 1 0 0 1 1 1 1 GNAT acetyltransferase 2 tRNA_bind_2 PF13725.6 EDO18579.1 - 2e-92 309.2 5.9 3.9e-92 308.2 5.9 1.5 1 0 0 1 1 1 1 Possible tRNA binding domain Helicase_RecD PF05127.14 EDO18579.1 - 9.1e-66 221.1 0.0 3.5e-65 219.2 0.0 2.0 2 0 0 2 2 2 1 Helicase DUF1726 PF08351.11 EDO18579.1 - 4.7e-34 116.2 0.1 1.5e-33 114.6 0.1 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF1726) AAA_22 PF13401.6 EDO18579.1 - 0.006 16.9 0.0 0.24 11.7 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 EDO18579.1 - 0.0075 16.6 0.1 0.056 13.8 0.0 2.5 3 0 0 3 3 3 1 AAA domain DEAD PF00270.29 EDO18579.1 - 0.01 15.6 0.0 0.022 14.5 0.0 1.5 1 0 0 1 1 1 0 DEAD/DEAH box helicase CDP-OH_P_transf PF01066.21 EDO18580.1 - 3.9e-15 56.4 0.4 3.9e-15 56.4 0.4 3.1 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase AD PF09793.9 EDO18582.1 - 5.1e-24 84.2 0.0 7.5e-24 83.7 0.0 1.3 1 0 0 1 1 1 1 Anticodon-binding domain Peptidase_C25_C PF03785.14 EDO18582.1 - 0.037 13.9 0.1 0.14 12.0 0.0 1.9 2 0 0 2 2 2 0 Peptidase family C25, C terminal ig-like domain Gp138_N PF18352.1 EDO18582.1 - 0.083 13.0 0.0 0.15 12.1 0.0 1.4 1 0 0 1 1 1 0 Phage protein Gp138 N-terminal domain STN PF07660.14 EDO18582.1 - 0.12 12.2 0.2 0.12 12.2 0.2 2.0 3 0 0 3 3 3 0 Secretin and TonB N terminus short domain N1221 PF07923.13 EDO18583.1 - 5.8e-68 229.2 1.7 1e-67 228.3 1.7 1.4 1 0 0 1 1 1 1 N1221-like protein DUF3402 PF11882.8 EDO18583.1 - 1.4e-55 189.3 16.6 1.7e-22 80.2 0.1 3.6 2 1 2 4 4 4 3 Domain of unknown function (DUF3402) GCP_N_terminal PF17681.1 EDO18584.1 - 1.4e-39 136.5 3.4 1.4e-39 136.5 3.4 2.4 3 0 0 3 3 3 1 Gamma tubulin complex component N-terminal GCP_C_terminal PF04130.13 EDO18584.1 - 2.7e-32 112.5 8.2 2.7e-32 112.5 8.2 1.9 2 0 0 2 2 2 1 Gamma tubulin complex component C-terminal Erf4 PF10256.9 EDO18584.1 - 0.076 13.1 0.3 0.076 13.1 0.3 3.3 4 0 0 4 4 4 0 Golgin subfamily A member 7/ERF4 family DUF3412 PF11892.8 EDO18584.1 - 0.081 13.0 1.9 0.14 12.3 0.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3412) MFS_1 PF07690.16 EDO18585.1 - 1.5e-24 86.6 45.9 1e-14 54.3 28.7 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EDO18585.1 - 5.5e-08 32.1 20.8 4.7e-07 29.0 3.7 2.2 2 0 0 2 2 2 2 Sugar (and other) transporter Gar1 PF04410.14 EDO18586.1 - 1e-40 139.1 2.5 1e-40 139.1 2.5 3.2 5 0 0 5 5 5 1 Gar1/Naf1 RNA binding region DUF1835 PF08874.10 EDO18586.1 - 0.43 10.8 0.0 0.43 10.8 0.0 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF1835) DUF2870 PF11069.8 EDO18586.1 - 3.4 8.1 11.5 0.24 11.8 3.5 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2870) MutS_V PF00488.21 EDO18587.1 - 4.2e-66 222.6 0.0 8.6e-66 221.6 0.0 1.5 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 EDO18587.1 - 8.7e-35 120.7 1.4 2.5e-34 119.2 1.4 1.8 1 0 0 1 1 1 1 MutS domain III MutS_I PF01624.20 EDO18587.1 - 1e-25 90.1 0.0 3.1e-25 88.6 0.0 1.9 2 0 0 2 2 2 1 MutS domain I MutS_II PF05188.17 EDO18587.1 - 8.9e-09 35.7 0.2 5.7e-08 33.1 0.1 2.5 2 0 0 2 2 2 1 MutS domain II Vps4_C PF09336.10 EDO18587.1 - 0.071 13.1 0.0 0.31 11.1 0.0 2.1 2 0 0 2 2 2 0 Vps4 C terminal oligomerisation domain N-SET PF11764.8 EDO18588.1 - 9.4e-51 172.3 3.9 9.4e-51 172.3 3.9 2.9 3 0 0 3 3 3 1 COMPASS (Complex proteins associated with Set1p) component N SET_assoc PF11767.8 EDO18588.1 - 3.4e-20 71.4 0.1 7.8e-20 70.3 0.1 1.6 1 0 0 1 1 1 1 Histone lysine methyltransferase SET associated SET PF00856.28 EDO18588.1 - 3.3e-17 63.4 0.2 3.3e-17 63.4 0.2 3.7 2 2 0 2 2 2 1 SET domain RRM_1 PF00076.22 EDO18588.1 - 0.019 14.8 0.0 0.072 12.9 0.0 2.0 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) ORC6 PF05460.13 EDO18589.1 - 7.7e-120 400.4 6.4 9e-120 400.2 6.4 1.0 1 0 0 1 1 1 1 Origin recognition complex subunit 6 (ORC6) CDC45 PF02724.14 EDO18589.1 - 0.0072 14.7 1.5 0.0083 14.5 1.5 1.2 1 0 0 1 1 1 1 CDC45-like protein DUF1980 PF09323.10 EDO18589.1 - 2.3 8.1 6.3 0.24 11.3 0.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1980) PDZ_1 PF12812.7 EDO18590.1 - 8.7e-53 176.3 0.2 5.2e-37 125.7 0.0 3.3 3 0 0 3 3 3 2 PDZ-like domain Trypsin_2 PF13365.6 EDO18590.1 - 1.6e-25 90.7 0.0 1.1e-21 78.3 0.1 2.4 2 0 0 2 2 2 2 Trypsin-like peptidase domain PDZ_2 PF13180.6 EDO18590.1 - 5e-13 49.2 3.9 0.00022 21.5 0.3 5.0 5 0 0 5 5 5 3 PDZ domain PDZ_6 PF17820.1 EDO18590.1 - 2.6e-12 46.4 1.8 1.7e-05 24.6 0.1 4.5 5 0 0 5 5 5 2 PDZ domain PDZ PF00595.24 EDO18590.1 - 5.3e-10 39.5 0.2 3.4e-05 24.1 0.0 2.9 2 0 0 2 2 2 2 PDZ domain Tricorn_PDZ PF14685.6 EDO18590.1 - 1.7e-05 24.7 0.3 0.42 10.6 0.0 3.3 4 0 0 4 4 4 2 Tricorn protease PDZ domain Trypsin PF00089.26 EDO18590.1 - 0.00015 21.7 0.0 0.00048 20.0 0.0 1.9 2 1 0 2 2 2 1 Trypsin DUF31 PF01732.16 EDO18590.1 - 0.012 15.2 0.1 0.023 14.2 0.1 1.4 1 0 0 1 1 1 0 Putative peptidase (DUF31) Peptidase_S7 PF00949.21 EDO18590.1 - 0.023 14.5 0.1 0.08 12.8 0.1 1.9 2 0 0 2 2 2 0 Peptidase S7, Flavivirus NS3 serine protease Peptidase_S46 PF10459.9 EDO18590.1 - 0.078 11.6 0.3 0.17 10.5 0.0 1.6 2 0 0 2 2 2 0 Peptidase S46 GP44 PF17510.2 EDO18590.1 - 0.17 12.2 1.1 2.9 8.2 0.0 3.0 3 0 0 3 3 3 0 Gene product 44 TPR_1 PF00515.28 EDO18591.1 - 9.4e-22 75.9 20.3 3.9e-05 23.3 0.1 9.6 10 0 0 10 10 10 4 Tetratricopeptide repeat TPR_2 PF07719.17 EDO18591.1 - 1.2e-17 62.5 25.8 0.00017 21.4 0.1 10.4 11 0 0 11 11 11 4 Tetratricopeptide repeat TPR_8 PF13181.6 EDO18591.1 - 1.7e-13 49.6 24.3 0.0026 17.8 0.1 9.3 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_11 PF13414.6 EDO18591.1 - 2.5e-12 46.3 20.4 0.0071 16.0 0.8 7.6 6 2 1 7 7 7 5 TPR repeat TPR_19 PF14559.6 EDO18591.1 - 5.8e-11 42.7 22.3 0.007 16.9 1.5 6.8 6 1 1 7 7 6 4 Tetratricopeptide repeat TPR_12 PF13424.6 EDO18591.1 - 1.1e-10 41.6 8.9 0.041 14.2 0.3 7.7 6 1 1 7 7 7 3 Tetratricopeptide repeat TPR_16 PF13432.6 EDO18591.1 - 1.2e-10 41.8 9.8 0.045 14.4 0.0 6.1 6 1 1 7 7 5 4 Tetratricopeptide repeat TPR_14 PF13428.6 EDO18591.1 - 1.3e-10 41.1 6.4 0.91 10.5 0.1 8.5 7 2 2 9 9 9 1 Tetratricopeptide repeat TPR_9 PF13371.6 EDO18591.1 - 1.2e-06 28.5 0.0 0.36 11.0 0.0 3.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 EDO18591.1 - 1.8e-06 27.9 15.6 0.002 18.4 0.0 7.3 8 0 0 8 8 7 2 Tetratricopeptide repeat TPR_7 PF13176.6 EDO18591.1 - 2.5e-06 27.1 13.3 2.2 8.5 0.1 6.8 6 1 0 6 6 6 3 Tetratricopeptide repeat ANAPC3 PF12895.7 EDO18591.1 - 3.3e-06 27.2 15.7 0.0046 17.2 0.4 5.1 5 0 0 5 5 5 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_MalT PF17874.1 EDO18591.1 - 5.1e-05 22.8 0.4 0.024 14.0 0.9 3.0 2 1 1 3 3 3 1 MalT-like TPR region TPR_21 PF09976.9 EDO18591.1 - 5.7e-05 22.9 15.1 0.016 15.0 2.3 4.5 4 0 0 4 4 4 3 Tetratricopeptide repeat-like domain Exonuc_VII_S PF02609.16 EDO18591.1 - 0.002 18.1 1.4 0.017 15.1 1.4 2.7 1 0 0 1 1 1 1 Exonuclease VII small subunit OSCP PF00213.18 EDO18591.1 - 0.019 15.1 0.3 0.019 15.1 0.3 2.7 2 1 0 2 2 2 0 ATP synthase delta (OSCP) subunit AP3D1 PF06375.11 EDO18591.1 - 0.025 14.8 5.7 0.087 13.1 5.7 2.0 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 O-antigen_lig PF13425.6 EDO18591.1 - 0.27 10.0 2.4 0.47 9.2 2.4 1.3 1 0 0 1 1 1 0 O-antigen ligase like membrane protein PPR PF01535.20 EDO18591.1 - 0.32 11.3 3.5 1e+02 3.5 0.0 5.1 5 0 0 5 5 5 0 PPR repeat SpoIIIAH PF12685.7 EDO18591.1 - 2 8.2 15.6 0.045 13.6 7.6 2.3 2 0 0 2 2 2 0 SpoIIIAH-like protein TPR_10 PF13374.6 EDO18591.1 - 2.2 8.3 5.9 28 4.8 0.1 4.7 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_6 PF13174.6 EDO18591.1 - 4.1 8.2 20.2 8 7.3 0.0 7.2 8 0 0 8 8 7 0 Tetratricopeptide repeat CTU2 PF10288.9 EDO18592.1 - 3.6e-23 82.0 1.1 1.2e-22 80.3 1.1 2.0 1 0 0 1 1 1 1 Cytoplasmic tRNA 2-thiolation protein 2 DUF1904 PF08921.11 EDO18592.1 - 0.049 14.0 0.2 0.13 12.6 0.2 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF1904) DCP2 PF05026.13 EDO18593.1 - 1.6e-25 89.2 0.5 4.3e-25 87.8 0.5 1.8 1 0 0 1 1 1 1 Dcp2, box A domain NUDIX PF00293.28 EDO18593.1 - 5.7e-13 49.0 0.0 1.1e-12 48.1 0.0 1.5 1 0 0 1 1 1 1 NUDIX domain RhoGAP PF00620.27 EDO18594.1 - 6.5e-38 129.9 0.1 2.5e-37 128.0 0.1 2.1 1 0 0 1 1 1 1 RhoGAP domain PH PF00169.29 EDO18594.1 - 1.1e-11 45.2 0.1 7.1e-11 42.6 0.1 2.6 1 0 0 1 1 1 1 PH domain PX PF00787.24 EDO18594.1 - 3.6e-05 23.7 0.7 0.00012 22.0 0.7 1.9 1 0 0 1 1 1 1 PX domain VGPC1_C PF16799.5 EDO18594.1 - 0.071 13.1 0.2 0.23 11.5 0.2 1.9 1 0 0 1 1 1 0 C-terminal membrane-localisation domain of ion-channel, VCN1 DUF2796 PF10986.8 EDO18594.1 - 2.2 8.2 5.9 3.6 7.5 3.8 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2796) PA28_alpha PF02251.18 EDO18594.1 - 4.5 7.4 7.4 44 4.2 0.1 3.6 3 0 0 3 3 3 0 Proteasome activator pa28 alpha subunit TFIIA PF03153.13 EDO18595.1 - 5.8e-41 141.9 40.2 3.1e-23 83.4 34.4 2.2 1 1 1 2 2 2 2 Transcription factor IIA, alpha/beta subunit PEX11 PF05648.14 EDO18596.1 - 2.2e-07 30.6 2.3 9.7e-06 25.2 1.0 2.5 2 0 0 2 2 2 2 Peroxisomal biogenesis factor 11 (PEX11) Arginase PF00491.21 EDO18597.1 - 1.5e-75 254.3 0.0 1.8e-75 254.1 0.0 1.0 1 0 0 1 1 1 1 Arginase family GDPD PF03009.17 EDO18598.1 - 1.4e-82 277.3 0.1 1.4e-82 277.3 0.1 1.9 2 0 0 2 2 2 1 Glycerophosphoryl diester phosphodiesterase family Ank_2 PF12796.7 EDO18598.1 - 5e-20 71.9 0.0 7.2e-12 45.7 0.0 3.9 2 1 2 4 4 4 3 Ankyrin repeats (3 copies) SPX PF03105.19 EDO18598.1 - 1.7e-16 61.2 32.5 4.6e-10 40.0 2.4 4.4 3 1 2 5 5 5 3 SPX domain Ank_5 PF13857.6 EDO18598.1 - 4.1e-12 46.1 0.0 0.012 15.9 0.0 4.8 2 1 3 5 5 5 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EDO18598.1 - 4.4e-10 38.9 0.0 0.59 10.9 0.0 6.0 5 0 0 5 5 5 3 Ankyrin repeat Ank_4 PF13637.6 EDO18598.1 - 8.5e-10 39.0 0.1 0.0001 22.8 0.0 4.3 4 0 0 4 4 4 2 Ankyrin repeats (many copies) Ank PF00023.30 EDO18598.1 - 1.5e-08 34.7 0.0 0.55 10.8 0.0 4.0 3 0 0 3 3 3 3 Ankyrin repeat ABC1 PF03109.16 EDO18599.1 - 3.7e-19 69.0 0.0 8.6e-19 67.9 0.0 1.5 1 0 0 1 1 1 1 ABC1 family EBV-NA3 PF05009.12 EDO18600.1 - 0.066 12.7 0.2 0.092 12.3 0.2 1.2 1 0 0 1 1 1 0 Epstein-Barr virus nuclear antigen 3 (EBNA-3) PDH PF02153.17 EDO18601.1 - 6.9e-13 48.2 0.0 9.9e-13 47.7 0.0 1.3 1 0 0 1 1 1 1 Prephenate dehydrogenase NAD_binding_2 PF03446.15 EDO18601.1 - 4.7e-05 23.6 0.0 8.5e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase 2-Hacid_dh_C PF02826.19 EDO18601.1 - 6.1e-05 22.4 0.0 0.00012 21.5 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain F420_oxidored PF03807.17 EDO18601.1 - 0.00011 22.8 0.0 0.00022 21.7 0.0 1.6 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent 3HCDH_N PF02737.18 EDO18601.1 - 0.0026 17.7 0.0 0.0043 17.0 0.0 1.5 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ApbA PF02558.16 EDO18601.1 - 0.004 16.8 0.0 0.01 15.5 0.0 1.7 2 0 0 2 2 2 1 Ketopantoate reductase PanE/ApbA UDPG_MGDP_dh_N PF03721.14 EDO18601.1 - 0.01 15.4 0.0 0.018 14.6 0.0 1.5 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Shikimate_DH PF01488.20 EDO18601.1 - 0.075 13.1 0.0 0.21 11.7 0.0 1.7 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase TrkA_N PF02254.18 EDO18601.1 - 0.078 13.2 0.0 0.25 11.6 0.0 1.9 1 0 0 1 1 1 0 TrkA-N domain NAD_binding_7 PF13241.6 EDO18601.1 - 0.099 13.1 0.0 0.29 11.6 0.0 1.8 2 0 0 2 2 2 0 Putative NAD(P)-binding IlvN PF07991.12 EDO18601.1 - 0.14 11.7 0.0 0.24 10.9 0.0 1.3 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain MRP-S26 PF14943.6 EDO18602.1 - 0.086 12.8 5.2 0.034 14.1 2.2 1.7 2 0 0 2 2 2 0 Mitochondrial ribosome subunit S26 Pex24p PF06398.11 EDO18603.1 - 7.7e-42 143.6 17.4 9.9e-42 143.2 17.4 1.1 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin HSP70 PF00012.20 EDO18604.1 - 1.4e-184 614.7 13.0 4.3e-184 613.1 13.0 1.7 1 1 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EDO18604.1 - 4.1e-10 39.0 0.1 8.6e-10 37.9 0.1 1.4 1 0 0 1 1 1 1 MreB/Mbl protein FtsA PF14450.6 EDO18604.1 - 0.0017 18.7 4.9 0.0044 17.4 0.5 3.4 3 2 0 3 3 3 1 Cell division protein FtsA Peptidase_M22 PF00814.25 EDO18604.1 - 0.015 15.0 0.2 8.8 5.9 0.0 3.3 3 0 0 3 3 3 0 Glycoprotease family Ketoacyl-synt_C PF02801.22 EDO18604.1 - 0.039 14.0 0.0 0.1 12.6 0.0 1.8 1 0 0 1 1 1 0 Beta-ketoacyl synthase, C-terminal domain GYF PF02213.16 EDO18605.1 - 6.1e-15 54.6 0.1 1.4e-14 53.5 0.1 1.6 1 0 0 1 1 1 1 GYF domain UMP1 PF05348.11 EDO18606.1 - 2.2e-44 150.5 0.2 2.6e-44 150.2 0.2 1.1 1 0 0 1 1 1 1 Proteasome maturation factor UMP1 WD40 PF00400.32 EDO18607.1 - 6.2e-23 80.7 17.7 1.5e-05 25.7 0.2 7.0 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDO18607.1 - 1.9e-19 69.7 0.2 2.5e-06 27.7 0.0 5.9 2 1 4 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EDO18607.1 - 6.4e-06 25.1 0.5 0.16 10.6 0.0 3.1 1 1 2 3 3 3 2 Nucleoporin Nup120/160 Coatomer_WDAD PF04053.14 EDO18607.1 - 0.00021 20.5 0.2 0.0012 17.9 0.0 2.2 3 1 0 3 3 3 1 Coatomer WD associated region eIF2A PF08662.11 EDO18607.1 - 0.00033 20.6 0.1 1 9.2 0.0 4.0 3 1 1 4 4 4 1 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 EDO18607.1 - 0.0028 16.7 3.5 2 7.3 0.1 4.2 2 1 3 5 5 5 2 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 EDO18607.1 - 0.016 15.1 0.0 1.3 9.1 0.0 2.6 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat tRNA-synt_2 PF00152.20 EDO18608.1 - 4.5e-101 338.1 0.1 5.5e-101 337.8 0.1 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 EDO18608.1 - 0.00089 19.2 0.8 0.0019 18.1 0.8 1.6 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 EDO18608.1 - 0.0066 16.0 0.7 0.022 14.2 0.1 2.2 2 1 1 3 3 3 1 tRNA synthetases class II core domain (F) tRNA-synt_2b PF00587.25 EDO18608.1 - 0.095 12.7 0.0 0.15 12.1 0.0 1.3 1 0 0 1 1 1 0 tRNA synthetase class II core domain (G, H, P, S and T) PAXNEB PF05625.11 EDO18609.1 - 2.4e-95 319.8 1.3 2.9e-95 319.6 1.3 1.1 1 0 0 1 1 1 1 PAXNEB protein Pam17 PF08566.10 EDO18610.1 - 0.034 14.0 0.0 0.046 13.6 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial import protein Pam17 DUF4795 PF16043.5 EDO18610.1 - 0.25 10.9 6.5 4.5 6.8 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4795) Lebercilin PF15619.6 EDO18610.1 - 0.57 9.8 12.3 0.5 10.0 1.8 2.2 2 0 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease Romo1 PF10247.9 EDO18611.1 - 1.1e-28 99.4 6.3 1.4e-28 99.1 6.3 1.1 1 0 0 1 1 1 1 Reactive mitochondrial oxygen species modulator 1 CYSTM PF12734.7 EDO18611.1 - 0.1 12.9 0.2 0.2 12.0 0.2 1.5 1 0 0 1 1 1 0 Cysteine-rich TM module stress tolerance Abhydrolase_1 PF00561.20 EDO18612.1 - 6.8e-16 58.7 0.0 1.4e-15 57.7 0.0 1.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EDO18612.1 - 9.6e-07 28.3 0.0 6.6e-06 25.6 0.0 2.0 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EDO18612.1 - 0.0081 16.8 0.0 0.014 16.1 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF915 PF06028.11 EDO18612.1 - 0.044 13.1 0.0 0.14 11.5 0.0 1.7 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF915) Sec62 PF03839.16 EDO18613.1 - 3.1e-75 252.4 0.2 3.1e-75 252.4 0.2 1.3 2 0 0 2 2 2 1 Translocation protein Sec62 Claudin_3 PF06653.11 EDO18613.1 - 0.084 12.8 1.8 0.14 12.1 1.8 1.3 1 0 0 1 1 1 0 Tight junction protein, Claudin-like DUF3949 PF13133.6 EDO18613.1 - 0.25 11.8 3.9 1.4 9.4 1.5 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3949) MFS_1 PF07690.16 EDO18614.1 - 6e-54 183.3 17.6 6e-54 183.3 17.6 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EDO18614.1 - 7.7e-21 74.5 0.9 7.7e-21 74.5 0.9 3.0 3 0 0 3 3 3 2 Sugar (and other) transporter Pyr_redox_2 PF07992.14 EDO18615.1 - 4e-62 210.1 0.7 7.2e-62 209.3 0.3 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 EDO18615.1 - 1.3e-32 112.4 0.4 8.9e-31 106.4 0.1 2.9 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 EDO18615.1 - 5.7e-18 65.3 11.3 1.2e-17 64.2 2.6 3.1 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EDO18615.1 - 1.1e-15 57.7 3.7 2.2e-12 46.8 0.3 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EDO18615.1 - 1.1e-07 30.9 7.6 0.014 14.1 0.1 4.0 3 1 1 4 4 4 2 HI0933-like protein K_oxygenase PF13434.6 EDO18615.1 - 4.2e-06 26.1 0.0 7e-06 25.4 0.0 1.3 1 0 0 1 1 1 1 L-lysine 6-monooxygenase (NADPH-requiring) FAD_oxidored PF12831.7 EDO18615.1 - 8.4e-06 25.4 0.0 3.4e-05 23.4 0.0 1.8 2 0 0 2 2 2 1 FAD dependent oxidoreductase GIDA PF01134.22 EDO18615.1 - 2e-05 23.9 2.9 0.0001 21.5 0.5 2.6 2 0 0 2 2 2 1 Glucose inhibited division protein A AlaDh_PNT_C PF01262.21 EDO18615.1 - 0.0035 16.7 3.5 0.37 10.1 0.2 2.3 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_7 PF13241.6 EDO18615.1 - 0.015 15.7 0.1 13 6.3 0.0 2.8 3 0 0 3 3 3 0 Putative NAD(P)-binding DAO PF01266.24 EDO18615.1 - 0.13 11.8 0.0 0.13 11.8 0.0 3.1 2 1 0 3 3 3 0 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 EDO18615.1 - 0.17 11.1 3.6 3.4 6.8 0.1 2.3 2 0 0 2 2 2 0 FAD binding domain FAD_binding_2 PF00890.24 EDO18615.1 - 0.48 9.4 4.8 1.1 8.2 2.3 2.6 3 0 0 3 3 3 0 FAD binding domain UDPG_MGDP_dh_N PF03721.14 EDO18615.1 - 1.2 8.7 3.8 4.2 6.9 3.4 2.1 2 1 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Ribosomal_S6e PF01092.19 EDO18616.1 - 2.7e-56 188.9 0.2 5.5e-56 187.9 0.2 1.5 1 0 0 1 1 1 1 Ribosomal protein S6e SRF-TF PF00319.18 EDO18617.1 - 9.4e-20 69.9 0.0 1.8e-19 69.0 0.0 1.5 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) CytochromB561_N PF09786.9 EDO18618.1 - 0.27 10.2 12.1 0.29 10.1 12.1 1.1 1 0 0 1 1 1 0 Cytochrome B561, N terminal Plasmodium_Vir PF05795.11 EDO18618.1 - 0.3 10.4 5.7 0.35 10.3 5.7 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein SOG2 PF10428.9 EDO18618.1 - 0.37 9.9 20.2 0.39 9.9 20.2 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein Apt1 PF10351.9 EDO18618.1 - 0.42 9.4 7.8 0.48 9.2 7.8 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Macoilin PF09726.9 EDO18618.1 - 9.8 4.6 10.9 12 4.3 10.9 1.0 1 0 0 1 1 1 0 Macoilin family Ceramidase PF05875.12 EDO18619.1 - 1.6e-89 299.8 14.1 1.9e-89 299.6 14.1 1.0 1 0 0 1 1 1 1 Ceramidase HlyIII PF03006.20 EDO18619.1 - 0.00036 20.3 12.3 0.032 13.9 12.3 2.1 1 1 0 1 1 1 1 Haemolysin-III related DUF2975 PF11188.8 EDO18619.1 - 0.02 14.8 0.3 0.02 14.8 0.3 2.8 3 2 1 4 4 4 0 Protein of unknown function (DUF2975) ECF_trnsprt PF12822.7 EDO18619.1 - 0.029 14.5 14.1 0.13 12.3 0.7 2.4 2 1 0 2 2 2 0 ECF transporter, substrate-specific component DUF4181 PF13789.6 EDO18619.1 - 0.063 13.6 0.1 0.063 13.6 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4181) CD20 PF04103.15 EDO18619.1 - 0.12 12.5 4.4 0.14 12.3 1.8 2.1 2 0 0 2 2 2 0 CD20-like family MerC PF03203.14 EDO18619.1 - 0.16 12.4 10.0 1.3 9.5 4.7 2.3 2 0 0 2 2 2 0 MerC mercury resistance protein FeoB_associated PF12669.7 EDO18619.1 - 0.79 10.2 3.6 2.9 8.4 0.1 3.1 3 0 0 3 3 3 0 FeoB-associated Cys-rich membrane protein Sec16_C PF12931.7 EDO18620.1 - 2.1e-74 250.9 0.0 3.8e-74 250.1 0.0 1.5 1 0 0 1 1 1 1 Sec23-binding domain of Sec16 Sec16 PF12932.7 EDO18620.1 - 1.7e-06 28.6 0.0 1.5e-05 25.5 0.0 2.8 1 0 0 1 1 1 1 Vesicle coat trafficking protein Sec16 mid-region Nup96 PF12110.8 EDO18620.1 - 0.072 12.2 0.0 0.16 11.1 0.0 1.5 1 0 0 1 1 1 0 Nuclear protein 96 tRNA_int_end_N2 PF12928.7 EDO18621.1 - 1.8e-14 53.6 0.0 3.3e-14 52.8 0.0 1.4 1 0 0 1 1 1 1 tRNA-splicing endonuclease subunit sen54 N-term AAA PF00004.29 EDO18622.1 - 1.2e-32 113.1 0.0 3e-32 111.8 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EDO18622.1 - 1.2e-06 28.9 0.1 4.5e-06 27.0 0.1 2.1 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EDO18622.1 - 2.7e-06 27.9 0.0 1.5e-05 25.5 0.0 2.1 1 1 0 1 1 1 1 AAA ATPase domain Rad17 PF03215.15 EDO18622.1 - 4.3e-05 23.5 0.4 0.00021 21.3 0.0 2.6 2 1 1 3 3 2 1 Rad17 P-loop domain AAA_18 PF13238.6 EDO18622.1 - 0.0001 22.8 0.0 0.0004 20.9 0.0 2.1 2 0 0 2 2 1 1 AAA domain AAA_11 PF13086.6 EDO18622.1 - 0.00013 21.8 0.0 0.00079 19.3 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EDO18622.1 - 0.00021 21.5 0.0 0.00046 20.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain ATPase_2 PF01637.18 EDO18622.1 - 0.00021 21.3 2.7 0.00054 19.9 1.3 2.3 1 1 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_14 PF13173.6 EDO18622.1 - 0.00041 20.4 0.1 0.0014 18.6 0.1 2.0 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EDO18622.1 - 0.00044 20.6 0.2 0.0057 17.0 0.0 2.5 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 EDO18622.1 - 0.0013 19.1 0.0 0.0052 17.2 0.0 2.1 1 0 0 1 1 1 1 RNA helicase AAA_30 PF13604.6 EDO18622.1 - 0.0031 17.3 0.0 0.0054 16.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain DUF2075 PF09848.9 EDO18622.1 - 0.0061 15.9 0.0 0.0094 15.2 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_23 PF13476.6 EDO18622.1 - 0.0064 17.0 2.0 0.017 15.6 1.4 2.2 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.6 EDO18622.1 - 0.0074 16.7 0.0 0.017 15.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_7 PF12775.7 EDO18622.1 - 0.0096 15.4 0.0 0.027 14.0 0.0 1.7 1 0 0 1 1 1 1 P-loop containing dynein motor region RuvB_N PF05496.12 EDO18622.1 - 0.01 15.6 0.0 0.022 14.5 0.0 1.5 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain Cytidylate_kin PF02224.18 EDO18622.1 - 0.011 15.5 0.0 0.024 14.4 0.0 1.5 1 0 0 1 1 1 0 Cytidylate kinase T2SSE PF00437.20 EDO18622.1 - 0.014 14.5 0.0 0.025 13.6 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein TsaE PF02367.17 EDO18622.1 - 0.015 15.3 0.0 0.03 14.3 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_5 PF07728.14 EDO18622.1 - 0.016 15.2 0.2 0.2 11.7 0.0 2.4 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) NTPase_1 PF03266.15 EDO18622.1 - 0.017 15.1 0.2 0.049 13.5 0.1 1.8 2 0 0 2 2 1 0 NTPase Sigma54_activ_2 PF14532.6 EDO18622.1 - 0.03 14.4 0.1 0.18 11.9 0.1 2.3 1 1 0 1 1 1 0 Sigma-54 interaction domain Viral_helicase1 PF01443.18 EDO18622.1 - 0.032 14.0 0.0 0.065 13.0 0.0 1.7 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase RsgA_GTPase PF03193.16 EDO18622.1 - 0.033 14.1 0.0 0.089 12.7 0.0 1.7 1 0 0 1 1 1 0 RsgA GTPase NB-ARC PF00931.22 EDO18622.1 - 0.039 13.1 0.0 0.16 11.1 0.0 1.9 2 0 0 2 2 2 0 NB-ARC domain AAA_25 PF13481.6 EDO18622.1 - 0.054 13.1 0.0 0.088 12.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_2 PF07724.14 EDO18622.1 - 0.057 13.5 0.0 0.2 11.7 0.0 2.0 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) NACHT PF05729.12 EDO18622.1 - 0.06 13.3 0.9 0.19 11.7 0.9 2.0 1 1 0 1 1 1 0 NACHT domain ADK PF00406.22 EDO18622.1 - 0.077 13.1 0.1 0.25 11.4 0.1 1.9 2 0 0 2 2 1 0 Adenylate kinase Mg_chelatase PF01078.21 EDO18622.1 - 0.086 12.2 0.0 0.16 11.3 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_24 PF13479.6 EDO18622.1 - 0.09 12.5 0.0 0.19 11.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 EDO18622.1 - 0.1 13.1 2.5 0.25 11.9 0.0 2.6 3 1 0 3 3 2 0 ABC transporter IstB_IS21 PF01695.17 EDO18622.1 - 0.14 11.9 0.0 0.36 10.5 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_28 PF13521.6 EDO18622.1 - 0.15 12.3 0.1 0.3 11.3 0.1 1.5 1 0 0 1 1 1 0 AAA domain DUF3535 PF12054.8 EDO18623.1 - 1.6e-114 383.5 0.0 1.6e-114 383.5 0.0 3.2 5 0 0 5 5 5 1 Domain of unknown function (DUF3535) SNF2_N PF00176.23 EDO18623.1 - 2.3e-70 237.0 0.1 6e-70 235.7 0.1 1.6 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EDO18623.1 - 1.8e-18 66.9 0.0 8.3e-18 64.8 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HEAT PF02985.22 EDO18623.1 - 1.3e-17 62.3 0.7 0.049 13.9 0.0 8.0 7 0 0 7 7 7 3 HEAT repeat HEAT_EZ PF13513.6 EDO18623.1 - 5.4e-07 30.0 2.7 0.12 12.9 0.1 6.5 7 0 0 7 7 7 2 HEAT-like repeat HEAT_2 PF13646.6 EDO18623.1 - 8e-06 26.2 1.8 0.83 10.1 0.0 5.4 6 1 0 6 6 6 2 HEAT repeats TAF6_C PF07571.13 EDO18623.1 - 2.2e-05 24.7 0.6 2.4 8.6 0.0 5.3 4 1 1 5 5 5 2 TAF6 C-terminal HEAT repeat domain Vac14_Fab1_bd PF12755.7 EDO18623.1 - 6e-05 23.6 0.0 3.5 8.3 0.0 5.1 4 0 0 4 4 4 1 Vacuolar 14 Fab1-binding region ERCC3_RAD25_C PF16203.5 EDO18623.1 - 0.0055 16.0 0.0 0.038 13.2 0.0 2.3 2 0 0 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase GUN4_N PF16416.5 EDO18623.1 - 0.042 13.8 0.3 0.62 10.1 0.0 2.8 2 0 0 2 2 2 0 ARM-like repeat domain, GUN4-N terminal S4 PF01479.25 EDO18624.1 - 6.3e-13 48.2 0.2 6.3e-13 48.2 0.2 2.0 2 0 0 2 2 2 1 S4 domain Ribosomal_L21e PF01157.18 EDO18625.1 - 2.4e-48 162.2 5.9 2.4e-48 162.2 5.9 1.7 2 0 0 2 2 2 1 Ribosomal protein L21e LRS4 PF10422.9 EDO18625.1 - 0.0084 15.7 0.1 0.01 15.4 0.1 1.1 1 0 0 1 1 1 1 Monopolin complex subunit LRS4 SIMPL PF04402.14 EDO18625.1 - 0.013 15.9 0.1 0.017 15.6 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF541) NpwBP PF12622.7 EDO18626.1 - 4.6e-07 30.5 0.0 4.6e-07 30.5 0.0 2.0 2 1 0 2 2 2 1 mRNA biogenesis factor GPI2 PF06432.11 EDO18627.1 - 2.4e-59 201.1 21.6 2.7e-59 200.9 21.6 1.1 1 0 0 1 1 1 1 Phosphatidylinositol N-acetylglucosaminyltransferase FUSC PF04632.12 EDO18627.1 - 0.04 12.5 0.1 0.055 12.0 0.1 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family WD40 PF00400.32 EDO18628.1 - 4.2e-50 166.6 17.4 5.7e-09 36.5 1.7 6.6 6 0 0 6 6 6 6 WD domain, G-beta repeat TFIID_NTD2 PF04494.15 EDO18628.1 - 1.9e-20 73.4 1.4 4.2e-20 72.3 1.4 1.7 1 0 0 1 1 1 1 WD40 associated region in TFIID subunit, NTD2 domain ANAPC4_WD40 PF12894.7 EDO18628.1 - 1.7e-16 60.3 0.1 0.031 14.6 0.0 5.5 2 1 3 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EDO18628.1 - 0.0041 16.1 2.1 0.43 9.5 0.0 4.0 1 1 4 5 5 5 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 EDO18628.1 - 0.0071 14.9 0.1 0.013 14.0 0.1 1.5 1 0 0 1 1 1 1 Cytochrome D1 heme domain TFIIA PF03153.13 EDO18628.1 - 0.012 15.7 24.0 0.012 15.6 22.7 1.7 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit nos_propeller PF18764.1 EDO18628.1 - 0.041 13.8 0.1 2.1 8.3 0.0 3.2 3 0 0 3 3 3 0 Nitrous oxide reductase propeller repeat Nup96 PF12110.8 EDO18628.1 - 0.058 12.5 0.5 0.12 11.5 0.5 1.4 1 0 0 1 1 1 0 Nuclear protein 96 PRCC PF10253.9 EDO18628.1 - 0.11 13.2 28.5 0.17 12.7 15.3 2.4 2 0 0 2 2 2 0 Mitotic checkpoint regulator, MAD2B-interacting GCR1_C PF12550.8 EDO18629.1 - 3.5e-22 78.5 0.4 1e-21 77.0 0.4 1.9 1 0 0 1 1 1 1 Transcriptional activator of glycolytic enzymes SKA2 PF16740.5 EDO18629.1 - 0.015 15.0 1.5 0.015 15.0 1.5 2.0 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 2 TetR_C_17 PF17922.1 EDO18629.1 - 0.054 13.6 0.1 6.6 6.9 0.0 3.1 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain AAA PF00004.29 EDO18630.1 - 3.8e-40 137.4 0.0 7e-39 133.3 0.0 2.6 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EDO18630.1 - 3.9e-09 36.2 0.0 9.9e-09 34.9 0.0 1.7 1 0 0 1 1 1 1 AAA+ lid domain Vps4_C PF09336.10 EDO18630.1 - 4.1e-07 29.9 0.0 3.2e-05 23.8 0.0 3.0 3 0 0 3 3 3 1 Vps4 C terminal oligomerisation domain RuvB_N PF05496.12 EDO18630.1 - 4.9e-05 23.1 0.0 0.00013 21.8 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EDO18630.1 - 9.2e-05 22.7 0.2 0.0086 16.4 0.2 2.8 1 1 0 1 1 1 1 AAA domain AAA_2 PF07724.14 EDO18630.1 - 0.00011 22.4 0.1 0.00089 19.4 0.0 2.6 3 0 0 3 3 3 1 AAA domain (Cdc48 subfamily) TIP49 PF06068.13 EDO18630.1 - 0.00068 18.9 0.0 0.00068 18.9 0.0 2.2 2 0 0 2 2 2 1 TIP49 P-loop domain AAA_5 PF07728.14 EDO18630.1 - 0.00097 19.1 0.0 0.0055 16.7 0.0 2.3 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.17 EDO18630.1 - 0.0019 18.0 0.0 0.014 15.1 0.0 2.3 2 0 0 2 2 2 1 IstB-like ATP binding protein TniB PF05621.11 EDO18630.1 - 0.002 17.6 0.0 1.8 7.9 0.0 2.6 1 1 0 2 2 2 2 Bacterial TniB protein AAA_16 PF13191.6 EDO18630.1 - 0.0071 16.7 0.1 0.13 12.6 0.1 2.4 1 1 1 2 2 2 1 AAA ATPase domain Mg_chelatase PF01078.21 EDO18630.1 - 0.011 15.1 0.1 0.011 15.1 0.1 2.2 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI AAA_14 PF13173.6 EDO18630.1 - 0.016 15.2 0.0 0.016 15.2 0.0 3.2 4 0 0 4 4 4 0 AAA domain AAA_7 PF12775.7 EDO18630.1 - 0.056 12.9 0.0 0.13 11.8 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_25 PF13481.6 EDO18630.1 - 0.075 12.6 0.0 0.58 9.7 0.0 2.2 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 EDO18630.1 - 0.095 13.1 0.1 1.8 9.0 0.0 3.0 3 0 0 3 3 3 0 RNA helicase AAA_18 PF13238.6 EDO18630.1 - 0.12 12.9 0.1 0.12 12.9 0.1 3.2 3 2 0 3 3 2 0 AAA domain NACHT PF05729.12 EDO18630.1 - 0.14 12.0 1.6 5.9 6.8 0.0 3.2 2 1 1 3 3 3 0 NACHT domain AAA_17 PF13207.6 EDO18630.1 - 1 9.7 0.0 1 9.7 0.0 3.5 4 1 1 5 5 5 0 AAA domain Glyco_transf_15 PF01793.16 EDO18631.1 - 2e-107 359.2 8.6 2.5e-107 358.9 8.6 1.1 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase DUF2627 PF11118.8 EDO18631.1 - 0.12 12.9 0.7 0.23 12.1 0.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2627) Iso_dh PF00180.20 EDO18632.1 - 2.3e-124 415.1 0.0 2.6e-124 414.9 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Aminotran_5 PF00266.19 EDO18633.1 - 2.6e-101 339.2 0.0 3.5e-101 338.9 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 EDO18633.1 - 4.9e-09 35.9 0.4 8.9e-09 35.0 0.4 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_1_2 PF00155.21 EDO18633.1 - 2.7e-08 33.4 0.0 6.3e-08 32.2 0.0 1.6 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 EDO18633.1 - 2.8e-06 26.9 0.1 1.8e-05 24.3 0.1 2.1 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Pyridoxal_deC PF00282.19 EDO18633.1 - 0.0004 19.2 0.1 0.00077 18.3 0.1 1.4 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Cys_Met_Meta_PP PF01053.20 EDO18633.1 - 0.0013 17.4 0.2 0.0021 16.6 0.2 1.3 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme 4_1_CTD PF05902.13 EDO18633.1 - 1.1 9.3 3.4 0.6 10.2 0.8 1.8 2 0 0 2 2 2 0 4.1 protein C-terminal domain (CTD) Mito_carr PF00153.27 EDO18634.1 - 1.8e-51 172.0 4.0 1.2e-19 70.0 0.1 4.1 3 1 1 4 4 4 4 Mitochondrial carrier protein Dcc1 PF09724.9 EDO18635.1 - 3.9e-79 266.4 0.0 4.5e-79 266.2 0.0 1.0 1 0 0 1 1 1 1 Sister chromatid cohesion protein Dcc1 DEK_C PF08766.11 EDO18635.1 - 0.0022 17.8 0.1 0.0052 16.7 0.1 1.6 1 0 0 1 1 1 1 DEK C terminal domain DUF3507 PF12015.8 EDO18636.1 - 2.5e-70 235.9 3.8 2.5e-70 235.9 3.8 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF3507) DUF2015 PF09435.10 EDO18637.1 - 4e-33 113.6 0.4 4.7e-33 113.4 0.4 1.0 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF2015) DUF4479 PF14794.6 EDO18637.1 - 0.024 14.5 0.1 0.056 13.3 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4479) DUF1325 PF07039.11 EDO18638.1 - 2.5e-37 127.9 0.0 4.7e-37 127.0 0.0 1.5 1 0 0 1 1 1 1 SGF29 tudor-like domain Tudor_3 PF18115.1 EDO18638.1 - 4e-05 23.4 0.0 7.5e-05 22.5 0.0 1.4 1 0 0 1 1 1 1 DNA repair protein Crb2 Tudor domain Agenet PF05641.12 EDO18638.1 - 5.7e-05 23.5 0.1 0.024 15.1 0.0 2.6 2 0 0 2 2 2 2 Agenet domain DUF4537 PF15057.6 EDO18638.1 - 0.0071 16.4 0.0 0.015 15.3 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4537) PilZ PF07238.14 EDO18638.1 - 0.0092 16.3 0.0 0.036 14.4 0.0 2.0 1 1 0 1 1 1 1 PilZ domain Asp-B-Hydro_N PF05279.11 EDO18638.1 - 0.029 14.4 2.0 0.043 13.9 2.0 1.2 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Iso_dh PF00180.20 EDO18639.1 - 1.8e-69 234.6 0.0 2e-69 234.4 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase DUF2543 PF10820.8 EDO18639.1 - 0.13 12.5 0.4 1.2 9.4 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2543) UPF0052 PF01933.18 EDO18640.1 - 3.3e-59 200.5 0.0 3.9e-59 200.3 0.0 1.1 1 0 0 1 1 1 1 Uncharacterised protein family UPF0052 ABC_tran PF00005.27 EDO18641.1 - 6.8e-46 156.2 0.0 1.3e-22 80.8 0.0 4.5 3 2 0 3 3 2 2 ABC transporter 4HB PF17947.1 EDO18641.1 - 9.6e-28 96.1 0.2 5e-27 93.8 0.2 2.4 1 0 0 1 1 1 1 Four helical bundle domain AAA_21 PF13304.6 EDO18641.1 - 2.6e-17 63.6 0.7 0.0042 16.9 0.0 5.1 5 0 0 5 5 5 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EDO18641.1 - 2.9e-16 59.6 0.1 3.4e-06 26.6 0.0 4.0 2 2 1 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 EDO18641.1 - 1.4e-09 38.7 6.0 0.00033 21.2 0.0 3.4 4 0 0 4 4 3 2 AAA domain AAA_29 PF13555.6 EDO18641.1 - 1.8e-08 34.0 0.0 0.0061 16.3 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EDO18641.1 - 9.2e-08 32.2 0.0 0.0013 18.7 0.0 2.7 3 0 0 3 3 2 2 RsgA GTPase MMR_HSR1 PF01926.23 EDO18641.1 - 1.9e-07 31.2 0.1 0.0029 17.7 0.0 3.0 3 0 0 3 3 2 2 50S ribosome-binding GTPase AAA_22 PF13401.6 EDO18641.1 - 2e-07 31.3 0.1 0.023 15.0 0.0 4.1 4 1 0 4 4 4 2 AAA domain AAA_28 PF13521.6 EDO18641.1 - 4.9e-07 30.1 0.0 0.021 15.1 0.0 2.5 2 0 0 2 2 2 2 AAA domain Dynamin_N PF00350.23 EDO18641.1 - 1.2e-06 28.7 0.0 4e-05 23.7 0.0 2.8 2 0 0 2 2 2 1 Dynamin family HEAT PF02985.22 EDO18641.1 - 3.3e-06 26.9 0.2 0.024 14.9 0.1 4.6 4 0 0 4 4 3 1 HEAT repeat AAA_18 PF13238.6 EDO18641.1 - 9.6e-06 26.2 0.0 0.24 12.0 0.0 3.1 2 0 0 2 2 2 2 AAA domain RNA_helicase PF00910.22 EDO18641.1 - 9.8e-06 25.9 0.0 0.14 12.6 0.0 2.9 2 0 0 2 2 2 2 RNA helicase AAA PF00004.29 EDO18641.1 - 2.3e-05 24.8 0.0 0.64 10.4 0.0 4.0 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) MeaB PF03308.16 EDO18641.1 - 2.3e-05 23.5 0.1 0.14 11.1 0.0 2.4 2 0 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_33 PF13671.6 EDO18641.1 - 0.00018 21.7 0.0 0.64 10.2 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 EDO18641.1 - 0.00018 21.9 0.0 0.31 11.4 0.0 3.2 3 0 0 3 3 3 1 AAA ATPase domain AAA_27 PF13514.6 EDO18641.1 - 0.00027 20.6 0.0 0.24 11.0 0.0 2.5 2 0 0 2 2 2 1 AAA domain ParcG PF10274.9 EDO18641.1 - 0.00079 19.6 0.2 0.39 10.8 0.1 2.5 2 0 0 2 2 2 1 Parkin co-regulated protein DUF87 PF01935.17 EDO18641.1 - 0.00081 19.5 2.2 0.46 10.5 0.0 4.1 4 0 0 4 4 3 1 Helicase HerA, central domain MMS19_C PF12460.8 EDO18641.1 - 0.0009 18.5 0.7 0.77 8.8 0.1 2.5 2 0 0 2 2 2 2 RNAPII transcription regulator C-terminal AAA_30 PF13604.6 EDO18641.1 - 0.0013 18.5 0.0 2.3 7.9 0.0 3.2 3 0 0 3 3 3 1 AAA domain NACHT PF05729.12 EDO18641.1 - 0.0014 18.5 0.0 0.55 10.1 0.0 2.7 3 0 0 3 3 2 1 NACHT domain Vac14_Fab1_bd PF12755.7 EDO18641.1 - 0.0015 19.1 0.0 0.084 13.5 0.0 2.9 2 1 0 3 3 2 1 Vacuolar 14 Fab1-binding region AAA_24 PF13479.6 EDO18641.1 - 0.0015 18.3 0.0 1.3 8.7 0.0 3.3 4 0 0 4 4 3 1 AAA domain PduV-EutP PF10662.9 EDO18641.1 - 0.0015 18.3 0.0 0.29 10.8 0.0 3.0 3 0 0 3 3 2 1 Ethanolamine utilisation - propanediol utilisation HEAT_2 PF13646.6 EDO18641.1 - 0.0017 18.7 0.1 1.4 9.4 0.0 3.1 2 1 1 3 3 2 1 HEAT repeats HEAT_EZ PF13513.6 EDO18641.1 - 0.0023 18.4 0.2 3.6 8.2 0.0 4.5 5 0 0 5 5 3 0 HEAT-like repeat AAA_14 PF13173.6 EDO18641.1 - 0.0027 17.8 0.0 5 7.2 0.0 3.3 3 0 0 3 3 2 0 AAA domain CLASP_N PF12348.8 EDO18641.1 - 0.0033 17.0 0.2 0.033 13.7 0.2 2.3 1 1 1 2 2 2 1 CLASP N terminal Rad17 PF03215.15 EDO18641.1 - 0.0052 16.7 0.0 4.8 7.0 0.0 2.8 2 0 0 2 2 2 0 Rad17 P-loop domain ATPase_2 PF01637.18 EDO18641.1 - 0.0068 16.3 0.2 9.9 6.0 0.0 3.4 3 0 0 3 3 3 0 ATPase domain predominantly from Archaea SbcCD_C PF13558.6 EDO18641.1 - 0.007 16.6 0.0 0.79 10.0 0.0 3.0 2 1 0 2 2 2 1 Putative exonuclease SbcCD, C subunit IstB_IS21 PF01695.17 EDO18641.1 - 0.0085 15.8 0.2 7 6.3 0.1 3.4 2 1 1 3 3 3 0 IstB-like ATP binding protein cobW PF02492.19 EDO18641.1 - 0.0094 15.5 0.0 4.3 6.9 0.0 2.8 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_13 PF13166.6 EDO18641.1 - 0.011 14.4 3.4 2 6.9 0.0 3.6 3 1 0 4 4 4 0 AAA domain CLP1_P PF16575.5 EDO18641.1 - 0.012 15.4 0.0 1.5 8.6 0.0 3.0 2 0 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop Ploopntkinase3 PF18751.1 EDO18641.1 - 0.019 14.9 0.0 4.4 7.2 0.0 2.6 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 Roc PF08477.13 EDO18641.1 - 0.02 15.1 0.0 11 6.2 0.0 2.7 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_7 PF12775.7 EDO18641.1 - 0.021 14.3 0.1 4.8 6.6 0.0 2.7 3 0 0 3 3 2 0 P-loop containing dynein motor region UME PF08064.13 EDO18641.1 - 0.029 14.3 0.4 0.098 12.6 0.4 1.9 1 0 0 1 1 1 0 UME (NUC010) domain T2SSE PF00437.20 EDO18641.1 - 0.03 13.4 0.0 0.43 9.6 0.0 2.4 2 0 0 2 2 2 0 Type II/IV secretion system protein Cytidylate_kin PF02224.18 EDO18641.1 - 0.031 14.0 0.0 9.1 5.9 0.0 2.4 2 0 0 2 2 2 0 Cytidylate kinase NTPase_1 PF03266.15 EDO18641.1 - 0.038 13.9 0.1 14 5.5 0.0 2.9 3 0 0 3 3 2 0 NTPase AAA_15 PF13175.6 EDO18641.1 - 0.046 13.4 11.9 0.53 9.9 0.0 4.4 7 0 0 7 7 4 0 AAA ATPase domain RE_HindVP PF09519.10 EDO18641.1 - 0.051 12.6 0.3 0.091 11.8 0.3 1.3 1 0 0 1 1 1 0 HindVP restriction endonuclease Septin PF00735.18 EDO18641.1 - 0.051 12.8 0.0 2.5 7.3 0.0 2.5 2 0 0 2 2 2 0 Septin ATP_bind_1 PF03029.17 EDO18641.1 - 0.055 13.3 0.1 8 6.2 0.0 2.7 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein CRM1_C PF08767.11 EDO18641.1 - 0.06 12.5 0.0 0.13 11.4 0.0 1.5 1 0 0 1 1 1 0 CRM1 C terminal G-alpha PF00503.20 EDO18641.1 - 0.065 12.4 0.0 6.3 5.9 0.0 2.6 2 0 0 2 2 2 0 G-protein alpha subunit MutS_V PF00488.21 EDO18641.1 - 0.093 12.7 0.1 6.4 6.8 0.1 2.6 2 0 0 2 2 2 0 MutS domain V TsaE PF02367.17 EDO18641.1 - 0.093 12.7 0.1 6.6 6.7 0.0 2.4 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE MukB PF04310.12 EDO18641.1 - 0.15 11.9 0.1 14 5.4 0.0 2.5 2 0 0 2 2 2 0 MukB N-terminal YmgB PF10798.8 EDO18641.1 - 0.17 11.7 0.4 20 5.1 0.0 2.7 2 0 0 2 2 2 0 Biofilm development protein YmgB/AriR SNF2_N PF00176.23 EDO18642.1 - 3.6e-44 150.9 0.2 7.4e-44 149.9 0.2 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain zf-C3HC4_2 PF13923.6 EDO18642.1 - 5.6e-12 45.3 9.3 1.1e-11 44.4 9.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EDO18642.1 - 1.4e-10 41.3 11.2 2e-10 40.8 9.8 2.1 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_3 PF13920.6 EDO18642.1 - 5.2e-10 39.0 6.8 1.1e-09 38.0 6.8 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EDO18642.1 - 8.9e-09 35.1 11.5 2e-08 33.9 11.5 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EDO18642.1 - 3.8e-08 33.1 6.5 7.1e-08 32.2 6.5 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 EDO18642.1 - 1.1e-06 28.5 7.4 2.6e-06 27.3 7.4 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-rbx1 PF12678.7 EDO18642.1 - 6.6e-06 26.3 10.6 2.7e-05 24.4 10.6 2.1 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 EDO18642.1 - 9e-05 22.4 10.6 0.00021 21.1 10.6 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 EDO18642.1 - 0.00023 21.2 10.0 0.00054 20.1 10.0 1.7 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_10 PF16685.5 EDO18642.1 - 0.0076 16.4 3.5 0.0076 16.4 3.5 2.2 2 0 0 2 2 1 1 zinc RING finger of MSL2 zf-ANAPC11 PF12861.7 EDO18642.1 - 0.013 15.5 2.1 0.043 13.9 2.1 1.9 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Helicase_C PF00271.31 EDO18642.1 - 0.057 13.8 0.0 0.057 13.8 0.0 3.0 3 0 0 3 3 2 0 Helicase conserved C-terminal domain zf-P11 PF03854.14 EDO18642.1 - 0.13 11.9 12.3 0.035 13.8 8.4 2.0 2 0 0 2 2 1 0 P-11 zinc finger zf-RING_11 PF17123.5 EDO18642.1 - 0.28 11.0 7.1 0.85 9.4 7.1 2.0 1 0 0 1 1 1 0 RING-like zinc finger zf-Nse PF11789.8 EDO18642.1 - 0.29 11.0 4.3 0.82 9.5 4.3 1.7 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit DUF3020 PF11223.8 EDO18642.1 - 0.44 11.1 7.1 2.5 8.7 7.1 2.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3020) Zn_ribbon_17 PF17120.5 EDO18642.1 - 0.71 9.5 5.0 1.5 8.5 5.0 1.5 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-RING_4 PF14570.6 EDO18642.1 - 1.3 8.8 7.9 4.8 7.0 7.9 2.0 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING_6 PF14835.6 EDO18642.1 - 2.4 8.1 5.6 1.2 9.1 2.8 2.0 2 0 0 2 2 2 0 zf-RING of BARD1-type protein Retrotrans_gag PF03732.17 EDO18643.1 - 7.1e-07 29.4 0.0 1.3e-06 28.6 0.0 1.5 1 0 0 1 1 1 1 Retrotransposon gag protein zf-CCHC PF00098.23 EDO18643.1 - 0.00037 20.4 2.5 0.0006 19.8 2.5 1.3 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_5 PF14787.6 EDO18643.1 - 0.0043 16.7 1.3 0.0078 15.9 1.3 1.4 1 0 0 1 1 1 1 GAG-polyprotein viral zinc-finger zf-CCHC_2 PF13696.6 EDO18643.1 - 0.015 15.1 0.6 0.024 14.5 0.6 1.3 1 0 0 1 1 1 0 Zinc knuckle Rab15_effector PF15208.6 EDO18643.1 - 0.054 12.8 0.0 0.1 11.9 0.0 1.4 1 0 0 1 1 1 0 Rab15 effector RVT_1 PF00078.27 EDO18644.1 - 2e-34 119.1 0.1 3.5e-34 118.2 0.1 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 EDO18644.1 - 1.8e-27 95.3 0.0 3.6e-27 94.3 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Peptidase_A2B PF12384.8 EDO18644.1 - 5.5e-25 87.9 1.1 1.3e-24 86.7 1.1 1.6 1 0 0 1 1 1 1 Ty3 transposon peptidase RT_RNaseH PF17917.1 EDO18644.1 - 6.6e-25 87.4 0.0 1.6e-24 86.2 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 EDO18644.1 - 9.6e-18 64.0 2.7 2.7e-17 62.6 2.7 1.8 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 EDO18644.1 - 8.6e-13 48.5 0.0 2.1e-12 47.3 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Asp_protease_2 PF13650.6 EDO18644.1 - 3.6e-06 27.5 0.0 8.5e-06 26.3 0.0 1.7 1 0 0 1 1 1 1 Aspartyl protease RVP_2 PF08284.11 EDO18644.1 - 7e-06 25.8 0.0 1.5e-05 24.8 0.0 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease gag-asp_proteas PF13975.6 EDO18644.1 - 3.4e-05 24.3 0.0 7.2e-05 23.3 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease DUF1758 PF05585.12 EDO18644.1 - 0.0003 20.6 0.0 0.00073 19.3 0.0 1.6 1 0 0 1 1 1 1 Putative peptidase (DUF1758) zf-H2C2 PF09337.10 EDO18644.1 - 0.0065 16.7 0.4 0.032 14.4 0.1 2.4 3 0 0 3 3 3 1 H2C2 zinc finger Peptidase_A3 PF02160.15 EDO18644.1 - 0.011 15.2 0.1 0.024 14.1 0.1 1.4 1 0 0 1 1 1 0 Cauliflower mosaic virus peptidase (A3) RVP PF00077.20 EDO18644.1 - 0.055 13.8 0.1 0.49 10.7 0.0 2.4 2 0 0 2 2 2 0 Retroviral aspartyl protease zf-Di19 PF05605.12 EDO18645.1 - 0.0045 17.2 0.1 0.0058 16.9 0.1 1.2 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding zf-met PF12874.7 EDO18645.1 - 0.012 15.9 0.1 0.018 15.5 0.1 1.2 1 0 0 1 1 1 0 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.6 EDO18645.1 - 0.028 15.3 0.7 0.038 14.8 0.7 1.3 1 0 0 1 1 1 0 C2H2-type zinc finger zf-C2H2_9 PF16293.5 EDO18645.1 - 0.031 14.1 0.1 0.045 13.6 0.1 1.3 1 0 0 1 1 1 0 C2H2 type zinc-finger (1 copy) zf-C2H2 PF00096.26 EDO18645.1 - 0.11 13.0 0.9 0.16 12.5 0.9 1.3 1 0 0 1 1 1 0 Zinc finger, C2H2 type WD40 PF00400.32 EDO18646.1 - 4.5e-07 30.4 22.6 0.65 11.0 0.1 8.8 8 1 1 9 9 9 4 WD domain, G-beta repeat WD40_like PF17005.5 EDO18646.1 - 2.3e-06 27.1 3.9 0.0017 17.8 0.7 4.2 3 1 1 4 4 4 2 WD40-like domain ANAPC4_WD40 PF12894.7 EDO18646.1 - 1.2e-05 25.5 6.1 0.41 11.0 0.1 6.4 3 2 4 7 7 7 2 Anaphase-promoting complex subunit 4 WD40 domain MMS1_N PF10433.9 EDO18646.1 - 0.0077 14.9 6.3 0.056 12.1 0.1 3.6 2 2 2 4 4 4 2 Mono-functional DNA-alkylating methyl methanesulfonate N-term HPS3_N PF14761.6 EDO18646.1 - 0.088 12.3 0.9 10 5.6 0.2 2.9 3 0 0 3 3 3 0 Hermansky-Pudlak syndrome 3 LAG1-DNAbind PF09271.11 EDO18646.1 - 0.15 12.7 0.6 2.1 9.0 0.0 2.6 3 0 0 3 3 3 0 LAG1, DNA binding Cnd3 PF12719.7 EDO18647.1 - 2.7e-88 296.0 5.7 4e-87 292.1 4.1 3.0 2 1 0 2 2 2 1 Nuclear condensing complex subunits, C-term domain HEAT PF02985.22 EDO18647.1 - 5e-11 41.9 0.7 0.34 11.3 0.0 5.8 5 0 0 5 5 5 3 HEAT repeat HEAT_2 PF13646.6 EDO18647.1 - 5.1e-07 30.0 0.7 0.01 16.2 0.3 3.2 3 0 0 3 3 3 2 HEAT repeats HEAT_EZ PF13513.6 EDO18647.1 - 0.0008 19.9 0.0 70 4.1 0.0 5.2 7 0 0 7 7 7 0 HEAT-like repeat Cnd1 PF12717.7 EDO18647.1 - 0.0046 17.0 0.1 0.0046 17.0 0.1 4.4 4 1 0 5 5 5 1 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 EDO18647.1 - 0.12 13.0 2.7 1.4 9.5 0.2 3.9 4 0 0 4 4 4 0 Vacuolar 14 Fab1-binding region VHS PF00790.19 EDO18647.1 - 0.99 9.3 9.5 11 5.9 0.0 5.0 5 1 1 6 6 6 0 VHS domain Swi5 PF07061.11 EDO18648.1 - 2.9e-19 68.9 0.1 3.1e-19 68.8 0.1 1.0 1 0 0 1 1 1 1 Swi5 VASt PF16016.5 EDO18649.1 - 1.6e-73 246.2 1.2 2.3e-36 125.5 0.1 2.6 2 0 0 2 2 2 2 VAD1 Analog of StAR-related lipid transfer domain GRAM PF02893.20 EDO18649.1 - 8.4e-29 99.8 0.1 1.9e-28 98.6 0.1 1.7 1 0 0 1 1 1 1 GRAM domain Skp1 PF01466.19 EDO18650.1 - 1.3e-24 86.0 0.1 1.3e-24 86.0 0.1 2.5 2 0 0 2 2 2 1 Skp1 family, dimerisation domain Skp1_POZ PF03931.15 EDO18650.1 - 2.8e-14 53.0 0.2 1.9e-06 27.9 0.1 2.5 2 0 0 2 2 2 2 Skp1 family, tetramerisation domain DNA_pol_phi PF04931.13 EDO18650.1 - 4.6 5.2 11.5 5.9 4.9 11.5 1.1 1 0 0 1 1 1 0 DNA polymerase phi Peroxin-3 PF04882.12 EDO18651.1 - 8.4e-104 348.2 17.1 4.6e-103 345.7 17.1 1.8 1 1 0 1 1 1 1 Peroxin-3 Thioredoxin_7 PF13899.6 EDO18652.1 - 2.5e-24 85.3 0.0 4.9e-24 84.3 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin-like UBX PF00789.20 EDO18652.1 - 3.3e-16 59.3 0.0 7.2e-16 58.2 0.0 1.6 1 0 0 1 1 1 1 UBX domain UBA_4 PF14555.6 EDO18652.1 - 1e-13 50.9 0.0 1e-13 50.9 0.0 1.8 2 0 0 2 2 2 1 UBA-like domain C2-set PF05790.15 EDO18652.1 - 0.017 15.3 0.6 0.036 14.3 0.6 1.6 1 0 0 1 1 1 0 Immunoglobulin C2-set domain SAM35 PF10806.8 EDO18653.1 - 9.5e-42 142.3 1.0 5.8e-41 139.7 0.0 2.3 2 0 0 2 2 2 1 SAM35, subunit of SAM coomplex GST_C_6 PF17171.4 EDO18653.1 - 0.0057 16.4 0.1 0.018 14.8 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain STE PF02200.16 EDO18654.1 - 8e-59 196.8 2.6 1.3e-58 196.2 2.6 1.3 1 0 0 1 1 1 1 STE like transcription factor Tcf25 PF04910.14 EDO18655.1 - 1.3e-80 271.1 1.2 1.3e-80 271.1 1.2 2.0 2 0 0 2 2 2 1 Transcriptional repressor TCF25 US30 PF17624.2 EDO18655.1 - 0.13 11.3 0.0 0.22 10.5 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function Rtf2 PF04641.12 EDO18655.1 - 8.3 5.7 18.6 5.1 6.4 16.8 1.4 1 1 0 1 1 1 0 Rtf2 RING-finger Ipi1_N PF12333.8 EDO18656.1 - 4.6e-27 94.6 0.2 1.1e-25 90.2 0.1 2.7 2 0 0 2 2 2 1 Rix1 complex component involved in 60S ribosome maturation Pox_polyA_pol PF03296.13 EDO18656.1 - 0.05 13.5 0.1 0.11 12.4 0.1 1.6 1 0 0 1 1 1 0 Poxvirus poly(A) polymerase nucleotidyltransferase domain SNF2_N PF00176.23 EDO18657.1 - 4.2e-65 219.8 0.3 8.6e-65 218.7 0.3 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EDO18657.1 - 2e-18 66.7 0.0 3.1e-17 62.9 0.0 2.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HSA PF07529.13 EDO18657.1 - 1.7e-17 63.5 10.2 1.7e-17 63.5 10.2 2.7 1 1 1 2 2 2 1 HSA ResIII PF04851.15 EDO18657.1 - 4.1e-12 46.4 0.0 4.1e-12 46.4 0.0 3.9 4 1 0 4 4 4 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EDO18657.1 - 1.3e-06 28.3 0.1 6.9e-06 25.9 0.0 2.4 2 0 0 2 2 2 1 DEAD/DEAH box helicase SBDS PF01172.18 EDO18658.1 - 2.2e-15 56.5 0.3 2.5e-15 56.3 0.3 1.0 1 0 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein Gar1 PF04410.14 EDO18659.1 - 1.1e-39 135.6 0.0 1.4e-39 135.4 0.0 1.0 1 0 0 1 1 1 1 Gar1/Naf1 RNA binding region Ribosomal_S15 PF00312.22 EDO18660.1 - 1e-28 99.4 0.2 3.4e-28 97.7 0.2 1.9 1 0 0 1 1 1 1 Ribosomal protein S15 ING PF12998.7 EDO18661.1 - 2.4e-19 69.8 7.4 4e-19 69.1 7.4 1.4 1 0 0 1 1 1 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.29 EDO18661.1 - 2.7e-06 27.2 8.0 2.7e-06 27.2 8.0 1.7 2 0 0 2 2 2 1 PHD-finger zf-HC5HC2H PF13771.6 EDO18661.1 - 0.0061 16.8 0.2 0.019 15.2 0.2 1.8 1 0 0 1 1 1 1 PHD-like zinc-binding domain CCDC53 PF10152.9 EDO18661.1 - 0.027 14.9 1.1 0.05 14.0 1.1 1.5 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex Fcf1 PF04900.12 EDO18662.1 - 3.7e-34 117.1 0.8 5.4e-34 116.5 0.2 1.5 2 0 0 2 2 2 1 Fcf1 PIN_9 PF18477.1 EDO18662.1 - 2.2e-14 53.7 0.0 4.1e-14 52.9 0.0 1.4 1 0 0 1 1 1 1 PIN like domain Imm-NTF2 PF15655.6 EDO18662.1 - 0.025 14.9 0.0 0.051 13.9 0.0 1.5 1 0 0 1 1 1 0 NTF2 fold immunity protein Rpp20 PF12328.8 EDO18665.1 - 0.029 14.3 1.8 0.058 13.4 1.8 1.5 1 0 0 1 1 1 0 Rpp20 subunit of nuclear RNase MRP and P Rpr2 PF04032.16 EDO18665.1 - 0.06 13.6 0.2 0.22 11.8 0.2 2.0 1 0 0 1 1 1 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain bZIP_1 PF00170.21 EDO18667.1 - 1.3e-05 25.2 17.7 2.7e-05 24.2 17.7 1.5 1 0 0 1 1 1 1 bZIP transcription factor Glutaredoxin2_C PF04399.13 EDO18667.1 - 0.26 11.1 3.0 0.71 9.7 3.0 1.7 1 0 0 1 1 1 0 Glutaredoxin 2, C terminal domain CENP-X PF09415.10 EDO18667.1 - 0.32 11.3 3.8 0.37 11.1 2.4 1.8 2 0 0 2 2 2 0 CENP-S associating Centromere protein X bZIP_2 PF07716.15 EDO18667.1 - 0.4 10.8 16.3 0.91 9.7 16.3 1.6 1 0 0 1 1 1 0 Basic region leucine zipper IATP PF04568.12 EDO18667.1 - 6 7.4 7.7 12 6.3 7.7 1.5 1 0 0 1 1 1 0 Mitochondrial ATPase inhibitor, IATP CENP-C_C PF11699.8 EDO18668.1 - 7.5e-28 96.6 1.8 1.6e-27 95.6 1.8 1.6 1 0 0 1 1 1 1 Mif2/CENP-C like Mif2_N PF15624.6 EDO18668.1 - 5e-06 27.3 0.2 5e-06 27.3 0.2 3.8 3 1 1 4 4 4 1 Kinetochore CENP-C fungal homologue, Mif2, N-terminal Cupin_2 PF07883.11 EDO18668.1 - 1.7e-05 24.5 0.0 3.3e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 Cupin domain RTP PF02334.16 EDO18668.1 - 0.12 13.1 0.9 0.37 11.4 0.9 1.8 1 0 0 1 1 1 0 Replication terminator protein MannoseP_isomer PF01050.18 EDO18668.1 - 0.12 12.3 0.0 0.25 11.2 0.0 1.5 1 0 0 1 1 1 0 Mannose-6-phosphate isomerase AT_hook PF02178.19 EDO18668.1 - 0.53 10.3 6.4 1.6 8.8 6.4 1.9 1 0 0 1 1 1 0 AT hook motif Pkinase PF00069.25 EDO18669.1 - 1.3e-71 241.1 0.0 3e-71 239.9 0.0 1.7 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO18669.1 - 7.4e-47 159.8 0.0 1.4e-46 158.9 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.28 EDO18669.1 - 2.3e-23 82.3 0.5 1.1e-22 80.1 0.0 2.5 2 0 0 2 2 2 1 P21-Rho-binding domain Kinase-like PF14531.6 EDO18669.1 - 1.3e-05 24.7 0.0 2.4e-05 23.8 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EDO18669.1 - 6.9e-05 21.8 0.6 0.00025 20.0 0.0 2.2 2 0 0 2 2 2 1 Fungal protein kinase TPR_20 PF14561.6 EDO18669.1 - 0.18 12.2 0.0 1.7 9.0 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat APH PF01636.23 EDO18669.1 - 0.21 11.5 0.0 1.4 8.8 0.0 2.0 1 1 1 2 2 2 0 Phosphotransferase enzyme family HGTP_anticodon2 PF12745.7 EDO18670.1 - 1.7e-88 296.6 2.8 1.7e-88 296.6 2.8 3.5 4 0 0 4 4 4 1 Anticodon binding domain of tRNAs Pkinase PF00069.25 EDO18670.1 - 5.2e-70 235.8 2.1 7.6e-41 140.2 0.1 4.1 3 1 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.17 EDO18670.1 - 1e-33 116.7 0.2 2.6e-19 69.5 0.0 3.5 3 0 0 3 3 3 3 Protein tyrosine kinase RWD PF05773.22 EDO18670.1 - 1.2e-14 54.5 2.1 5.5e-14 52.5 2.1 2.3 1 0 0 1 1 1 1 RWD domain tRNA-synt_His PF13393.6 EDO18670.1 - 2.5e-12 46.7 0.0 6e-12 45.5 0.0 1.6 2 0 0 2 2 2 1 Histidyl-tRNA synthetase Kinase-like PF14531.6 EDO18670.1 - 0.0027 17.1 0.0 0.21 10.9 0.0 2.6 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 EDO18670.1 - 0.011 15.6 0.1 0.033 14.1 0.0 1.7 2 0 0 2 2 2 0 Phosphotransferase enzyme family FTA2 PF13095.6 EDO18670.1 - 0.17 11.4 10.7 0.53 9.9 0.2 4.1 5 0 0 5 5 5 0 Kinetochore Sim4 complex subunit FTA2 PAP2 PF01569.21 EDO18671.1 - 2.9e-23 82.1 1.5 5.1e-23 81.4 0.9 1.8 1 1 0 1 1 1 1 PAP2 superfamily PAP2_3 PF14378.6 EDO18671.1 - 0.019 14.7 8.0 0.19 11.4 8.0 2.2 1 1 0 1 1 1 0 PAP2 superfamily UPF0154 PF03672.13 EDO18671.1 - 0.25 11.4 0.4 0.69 10.0 0.1 1.8 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0154) MerC PF03203.14 EDO18671.1 - 2.1 8.8 6.0 1.4 9.4 2.1 2.5 1 1 2 3 3 3 0 MerC mercury resistance protein 7TMR-DISM_7TM PF07695.11 EDO18671.1 - 3.1 7.6 17.5 0.16 11.8 6.0 2.5 3 0 0 3 3 3 0 7TM diverse intracellular signalling DUF4064 PF13273.6 EDO18671.1 - 7.5 6.9 7.5 0.73 10.2 0.8 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF4064) ATG16 PF08614.11 EDO18672.1 - 0.0039 17.4 12.8 0.0039 17.4 12.8 5.8 1 1 3 5 5 5 2 Autophagy protein 16 (ATG16) COMP PF11598.8 EDO18672.1 - 0.0042 17.5 1.9 1.2 9.7 0.0 3.8 3 0 0 3 3 3 1 Cartilage oligomeric matrix protein TTc_toxin_rep PF18807.1 EDO18672.1 - 0.074 12.9 0.3 0.25 11.2 0.3 1.9 1 0 0 1 1 1 0 Tripartite Tc toxins repeat TAF6_C PF07571.13 EDO18672.1 - 0.54 10.6 5.0 0.7 10.3 0.1 3.7 4 0 0 4 4 4 0 TAF6 C-terminal HEAT repeat domain Fe-S_assembly PF04384.13 EDO18672.1 - 8.9 7.0 8.7 5.1 7.8 0.1 4.8 6 0 0 6 6 6 0 Iron-sulphur cluster assembly DUF836 PF05768.14 EDO18673.1 - 3.1e-16 59.5 0.6 4.6e-16 59.0 0.6 1.3 1 0 0 1 1 1 1 Glutaredoxin-like domain (DUF836) Glutaredoxin PF00462.24 EDO18673.1 - 0.028 14.6 0.5 0.047 13.9 0.5 1.5 1 1 0 1 1 1 0 Glutaredoxin HisG PF01634.18 EDO18674.1 - 1.8e-54 184.1 0.7 2.4e-54 183.6 0.7 1.2 1 0 0 1 1 1 1 ATP phosphoribosyltransferase HisG_C PF08029.11 EDO18674.1 - 1e-23 83.3 0.0 2e-23 82.3 0.0 1.5 1 0 0 1 1 1 1 HisG, C-terminal domain NMT1 PF09084.11 EDO18674.1 - 0.0032 17.4 0.3 0.0049 16.8 0.3 1.3 1 0 0 1 1 1 1 NMT1/THI5 like FUN14 PF04930.15 EDO18675.1 - 2.7e-05 24.5 2.5 4.3e-05 23.8 2.5 1.5 1 1 0 1 1 1 1 FUN14 family UCH PF00443.29 EDO18676.1 - 3.2e-48 164.5 5.3 7.5e-48 163.3 5.3 1.7 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Peptidase_C98 PF15499.6 EDO18676.1 - 0.032 13.7 1.5 0.52 9.8 0.1 2.5 2 0 0 2 2 2 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase CBM9_2 PF16011.5 EDO18677.1 - 0.057 13.1 0.7 2.2 7.9 0.1 2.2 1 1 1 2 2 2 0 Carbohydrate-binding family 9 SWIM PF04434.17 EDO18677.1 - 0.84 9.4 0.1 0.84 9.4 0.1 2.2 2 0 0 2 2 2 0 SWIM zinc finger PET122 PF05476.11 EDO18678.1 - 7.3e-114 379.4 4.8 9.4e-114 379.1 4.8 1.1 1 0 0 1 1 1 1 PET122 DUF2603 PF10788.9 EDO18678.1 - 0.08 13.0 0.4 2 8.4 0.2 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF2603) 60KD_IMP PF02096.20 EDO18679.1 - 3.1e-18 66.2 0.3 3.1e-18 66.2 0.3 2.1 2 0 0 2 2 2 1 60Kd inner membrane protein RhoGAP PF00620.27 EDO18680.1 - 2.5e-40 137.8 0.5 3.9e-38 130.7 0.0 3.1 2 0 0 2 2 2 1 RhoGAP domain RasGEF_N PF00618.20 EDO18680.1 - 2.5e-16 59.8 2.8 2.5e-16 59.8 2.8 5.2 6 0 0 6 6 6 1 RasGEF N-terminal motif RasGEF PF00617.19 EDO18680.1 - 4.7e-12 46.5 1.9 4.7e-12 46.5 1.9 4.7 4 0 0 4 4 4 1 RasGEF domain PH PF00169.29 EDO18680.1 - 8.1e-06 26.3 4.9 0.0015 19.0 0.0 3.4 3 0 0 3 3 3 2 PH domain PH_9 PF15410.6 EDO18680.1 - 0.014 15.8 0.4 0.19 12.1 0.0 2.7 2 0 0 2 2 2 0 Pleckstrin homology domain Tfb5 PF06331.12 EDO18681.1 - 6e-26 90.2 0.2 6.9e-26 90.0 0.2 1.0 1 0 0 1 1 1 1 Transcription factor TFIIH complex subunit Tfb5 YokU PF14122.6 EDO18681.1 - 0.028 14.4 0.1 0.03 14.3 0.1 1.2 1 0 0 1 1 1 0 YokU-like protein, putative antitoxin Melibiase PF02065.18 EDO18681.1 - 0.079 11.9 0.2 0.082 11.8 0.2 1.0 1 0 0 1 1 1 0 Melibiase NDUF_B5 PF09781.9 EDO18681.1 - 0.082 12.5 0.1 0.13 11.8 0.1 1.4 1 1 0 1 1 1 0 NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit Clathrin PF00637.20 EDO18682.1 - 1.7e-29 102.5 2.6 1.7e-29 102.5 2.6 3.9 3 1 0 3 3 3 1 Region in Clathrin and VPS TPR_17 PF13431.6 EDO18682.1 - 0.00077 19.7 0.6 0.0045 17.3 0.0 2.7 3 0 0 3 3 3 1 Tetratricopeptide repeat Vps39_1 PF10366.9 EDO18682.1 - 0.0013 19.0 5.0 0.0018 18.5 0.2 3.2 3 0 0 3 3 3 1 Vacuolar sorting protein 39 domain 1 DDE_1 PF03184.19 EDO18683.1 - 1e-61 207.6 2.7 1.2e-61 207.4 1.5 1.8 2 0 0 2 2 2 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EDO18683.1 - 1.7e-10 40.8 0.6 1.7e-10 40.8 0.6 2.1 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain HTH_ABP1_N PF18107.1 EDO18683.1 - 0.0004 20.1 0.0 0.0004 20.1 0.0 2.7 3 0 0 3 3 3 1 Fission yeast centromere protein N-terminal domain WASH_WAHD PF11945.8 EDO18683.1 - 0.0035 16.9 1.9 0.0094 15.5 1.9 1.7 1 0 0 1 1 1 1 WAHD domain of WASH complex DUF846 PF05832.12 EDO18684.1 - 9.4e-47 158.5 6.5 1.2e-46 158.2 6.5 1.1 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF846) SGS PF05002.15 EDO18685.1 - 0.024 14.8 7.8 0.76 9.9 0.2 3.8 3 1 0 3 3 3 0 SGS domain Mt_ATP-synt_B PF05405.14 EDO18685.1 - 0.039 13.6 1.5 0.28 10.8 0.6 2.5 1 1 1 2 2 2 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) SSF PF00474.17 EDO18686.1 - 6.6e-07 28.5 32.3 2e-06 26.9 32.3 1.7 1 1 0 1 1 1 1 Sodium:solute symporter family CBFD_NFYB_HMF PF00808.23 EDO18687.1 - 7.2e-11 42.2 0.1 1e-10 41.8 0.1 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone SecE PF00584.20 EDO18688.1 - 5.6e-13 48.6 0.1 6.3e-13 48.4 0.1 1.1 1 0 0 1 1 1 1 SecE/Sec61-gamma subunits of protein translocation complex Coiled-coil_56 PF09813.9 EDO18688.1 - 0.039 14.0 0.0 0.043 13.9 0.0 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 56 CBFD_NFYB_HMF PF00808.23 EDO18689.1 - 7.9e-05 22.9 0.0 0.00011 22.4 0.0 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone SecE PF00584.20 EDO18690.1 - 5.6e-13 48.6 0.1 6.3e-13 48.4 0.1 1.1 1 0 0 1 1 1 1 SecE/Sec61-gamma subunits of protein translocation complex Coiled-coil_56 PF09813.9 EDO18690.1 - 0.037 14.1 0.0 0.043 13.9 0.0 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 56 Nop52 PF05997.12 EDO18691.1 - 3.4e-71 239.5 8.2 4.1e-71 239.2 8.2 1.1 1 0 0 1 1 1 1 Nucleolar protein,Nop52 TAN PF11640.8 EDO18691.1 - 0.0014 18.8 0.5 0.011 15.9 0.2 2.4 2 1 0 2 2 2 1 Telomere-length maintenance and DNA damage repair Retrotran_gag_2 PF14223.6 EDO18693.1 - 0.097 12.3 0.0 0.17 11.5 0.0 1.3 1 0 0 1 1 1 0 gag-polypeptide of LTR copia-type Helicase_C PF00271.31 EDO18694.1 - 5.4e-16 58.9 1.4 2.6e-15 56.7 0.1 2.6 2 0 0 2 2 2 1 Helicase conserved C-terminal domain OB_NTP_bind PF07717.16 EDO18694.1 - 9.1e-16 58.0 0.6 2.4e-15 56.7 0.0 2.1 2 0 0 2 2 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold RWD PF05773.22 EDO18694.1 - 1e-13 51.5 3.0 8.2e-13 48.7 3.0 2.7 1 1 0 1 1 1 1 RWD domain DEAD PF00270.29 EDO18694.1 - 3.6e-12 46.4 0.3 1.2e-11 44.7 0.3 1.9 1 0 0 1 1 1 1 DEAD/DEAH box helicase HA2 PF04408.23 EDO18694.1 - 1.9e-06 28.1 0.0 1.9e-06 28.1 0.0 3.2 3 0 0 3 3 3 1 Helicase associated domain (HA2) AAA_19 PF13245.6 EDO18694.1 - 4.2e-05 23.9 0.1 0.00034 21.0 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 EDO18694.1 - 0.0013 18.4 0.0 0.0028 17.4 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_22 PF13401.6 EDO18694.1 - 0.0034 17.7 0.1 0.022 15.0 0.0 2.5 2 0 0 2 2 1 1 AAA domain T2SSE PF00437.20 EDO18694.1 - 0.0055 15.8 0.2 0.013 14.6 0.0 1.6 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_23 PF13476.6 EDO18694.1 - 0.0073 16.8 0.2 0.0073 16.8 0.2 4.6 3 3 2 5 5 4 1 AAA domain ATPase PF06745.13 EDO18694.1 - 0.008 15.5 0.1 0.056 12.8 0.0 2.5 3 0 0 3 3 3 1 KaiC PhoH PF02562.16 EDO18694.1 - 0.014 14.9 0.0 0.05 13.0 0.0 2.0 1 1 0 1 1 1 0 PhoH-like protein FtsK_SpoIIIE PF01580.18 EDO18694.1 - 0.046 13.1 0.0 0.14 11.4 0.0 1.8 2 0 0 2 2 2 0 FtsK/SpoIIIE family ResIII PF04851.15 EDO18694.1 - 0.08 12.9 0.0 0.08 12.9 0.0 3.2 3 1 0 3 3 3 0 Type III restriction enzyme, res subunit AAA_30 PF13604.6 EDO18694.1 - 0.12 12.0 0.0 0.22 11.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 EDO18694.1 - 1.6 9.3 6.0 2.1 8.9 0.1 3.4 3 0 0 3 3 2 0 AAA domain CDC73_C PF05179.14 EDO18695.1 - 1.3e-55 187.4 4.4 1.3e-55 187.4 4.4 1.6 2 0 0 2 2 2 1 RNA pol II accessory factor, Cdc73 family, C-terminal Vps36_ESCRT-II PF11605.8 EDO18696.1 - 1.3e-32 111.8 0.1 4.1e-32 110.2 0.1 1.9 1 0 0 1 1 1 1 Vacuolar protein sorting protein 36 Vps36 Vps36-NZF-N PF16988.5 EDO18696.1 - 9.2e-24 82.6 4.2 9.2e-24 82.6 4.2 3.0 2 1 0 2 2 2 1 Vacuolar protein sorting 36 NZF-N zinc-finger domain EAP30 PF04157.16 EDO18696.1 - 1.5e-18 67.0 0.1 2.3e-18 66.3 0.1 1.3 1 0 0 1 1 1 1 EAP30/Vps36 family GRAM PF02893.20 EDO18696.1 - 8.5e-05 22.4 0.2 0.00058 19.7 0.0 2.3 2 1 0 2 2 2 1 GRAM domain zf-Sec23_Sec24 PF04810.15 EDO18696.1 - 0.013 15.5 0.1 0.013 15.5 0.1 3.1 3 0 0 3 3 3 0 Sec23/Sec24 zinc finger bPH_3 PF14470.6 EDO18696.1 - 0.019 15.3 0.1 0.079 13.3 0.0 2.1 2 0 0 2 2 2 0 Bacterial PH domain zf-RanBP PF00641.18 EDO18696.1 - 0.087 12.2 10.7 0.043 13.1 1.5 3.2 3 0 0 3 3 3 0 Zn-finger in Ran binding protein and others DZR PF12773.7 EDO18696.1 - 0.35 10.9 9.0 0.7 10.0 2.2 2.4 1 1 1 2 2 2 0 Double zinc ribbon HIPIP PF01355.17 EDO18696.1 - 0.94 9.9 3.2 0.87 10.0 0.6 2.4 1 1 1 2 2 2 0 High potential iron-sulfur protein zinc_ribbon_15 PF17032.5 EDO18696.1 - 7.7 7.4 11.8 4.9 8.0 9.2 2.2 2 1 0 2 2 2 0 zinc-ribbon family ABC_membrane_2 PF06472.15 EDO18697.1 - 4.7e-64 216.4 9.3 1.1e-41 143.0 0.3 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region 2 ABC_tran PF00005.27 EDO18697.1 - 6.1e-19 68.9 0.7 6.1e-17 62.4 0.0 2.7 2 0 0 2 2 2 1 ABC transporter AAA_21 PF13304.6 EDO18697.1 - 0.00035 20.5 0.2 0.00035 20.5 0.2 3.7 4 1 0 4 4 4 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EDO18697.1 - 0.02 14.6 0.0 0.083 12.6 0.0 2.0 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_22 PF13401.6 EDO18697.1 - 0.05 13.9 0.0 0.21 11.9 0.0 2.0 2 0 0 2 2 2 0 AAA domain SUR7 PF06687.12 EDO18698.1 - 1.4e-40 139.3 9.6 1.7e-40 139.0 9.6 1.0 1 0 0 1 1 1 1 SUR7/PalI family DUF2663 PF10864.8 EDO18698.1 - 0.018 15.4 1.0 0.12 12.8 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2663) Claudin_2 PF13903.6 EDO18698.1 - 0.22 11.2 13.8 0.047 13.5 8.3 2.3 2 1 0 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction DUF2207 PF09972.9 EDO18698.1 - 0.53 9.0 5.9 0.2 10.4 2.9 1.6 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) MIG-14_Wnt-bd PF06664.12 EDO18698.1 - 2.3 7.4 15.4 0.42 9.8 9.9 2.1 2 0 0 2 2 2 0 Wnt-binding factor required for Wnt secretion DUF4191 PF13829.6 EDO18698.1 - 6.6 6.0 4.8 6.2 6.1 3.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4191) MgtE PF01769.16 EDO18698.1 - 9.4 6.6 11.9 0.26 11.6 4.2 2.3 2 1 1 3 3 3 0 Divalent cation transporter SUR7 PF06687.12 EDO18699.1 - 3.5e-09 36.6 27.1 3.2e-07 30.2 12.1 3.3 2 2 0 2 2 2 2 SUR7/PalI family GATA PF00320.27 EDO18700.1 - 9.6e-09 34.7 8.6 2.8e-08 33.2 8.6 1.9 1 0 0 1 1 1 1 GATA zinc finger RE_NgoBV PF09564.10 EDO18700.1 - 0.092 12.2 0.1 0.16 11.4 0.1 1.3 1 0 0 1 1 1 0 NgoBV restriction endonuclease Orn_Arg_deC_N PF02784.16 EDO18701.1 - 1.3e-78 263.8 0.0 1.8e-78 263.3 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.22 EDO18701.1 - 5e-19 68.4 0.0 6.6e-19 68.0 0.0 1.4 1 1 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain Voldacs PF03517.13 EDO18702.1 - 1.2e-23 83.8 0.3 1.7e-23 83.2 0.3 1.3 1 0 0 1 1 1 1 Regulator of volume decrease after cellular swelling DUF1729 PF08354.10 EDO18703.1 - 1.5e-158 527.4 0.0 2.1e-158 526.8 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1729) Acyl_transf_1 PF00698.21 EDO18703.1 - 1.3e-101 340.3 0.0 1e-100 337.3 0.0 2.3 2 0 0 2 2 2 1 Acyl transferase domain FAS_meander PF17951.1 EDO18703.1 - 7e-43 145.9 0.1 3.2e-42 143.8 0.0 2.1 1 1 1 2 2 2 1 Fatty acid synthase meander beta sheet domain MaoC_dehydratas PF01575.19 EDO18703.1 - 1.5e-35 121.4 0.0 3e-35 120.5 0.0 1.5 1 0 0 1 1 1 1 MaoC like domain SAT PF16073.5 EDO18703.1 - 1.6e-35 123.0 0.0 1.7e-34 119.6 0.0 2.3 2 0 0 2 2 2 1 Starter unit:ACP transacylase in aflatoxin biosynthesis FAS_N PF17828.1 EDO18703.1 - 6.3e-32 110.3 0.6 8.5e-31 106.6 0.6 2.5 1 1 0 1 1 1 1 N-terminal domain in fatty acid synthase subunit beta MaoC_dehydrat_N PF13452.6 EDO18703.1 - 4.8e-15 55.9 0.0 1.1e-14 54.7 0.0 1.6 1 0 0 1 1 1 1 N-terminal half of MaoC dehydratase NMO PF03060.15 EDO18703.1 - 0.0047 16.4 0.0 0.05 13.0 0.0 2.6 1 1 0 1 1 1 1 Nitronate monooxygenase SRR1 PF07985.12 EDO18704.1 - 2.5e-16 59.4 0.1 4.4e-16 58.7 0.1 1.4 1 0 0 1 1 1 1 SRR1 Pribosyltran_N PF13793.6 EDO18705.1 - 1.5e-39 134.5 0.0 4.4e-39 133.0 0.0 1.8 1 0 0 1 1 1 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.6 EDO18705.1 - 8.2e-39 133.5 0.7 1.3e-30 106.9 0.2 2.2 2 0 0 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.27 EDO18705.1 - 2.6e-07 30.3 0.1 0.00042 19.9 0.0 2.2 2 0 0 2 2 2 2 Phosphoribosyl transferase domain UPRTase PF14681.6 EDO18705.1 - 0.04 13.4 0.1 0.076 12.4 0.1 1.5 1 0 0 1 1 1 0 Uracil phosphoribosyltransferase Ppx-GppA PF02541.16 EDO18705.1 - 0.12 11.8 0.0 0.21 11.0 0.0 1.4 1 0 0 1 1 1 0 Ppx/GppA phosphatase family Sirohm_synth_M PF14824.6 EDO18705.1 - 0.15 11.6 0.0 0.8 9.2 0.0 2.2 2 0 0 2 2 2 0 Sirohaem biosynthesis protein central His_Phos_2 PF00328.22 EDO18706.1 - 8.9e-134 446.6 0.2 1.3e-133 446.0 0.2 1.3 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) PPIP5K2_N PF18086.1 EDO18706.1 - 6.7e-38 128.7 0.0 2e-37 127.2 0.0 1.8 1 0 0 1 1 1 1 Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain RimK PF08443.11 EDO18706.1 - 1.8e-09 37.5 0.0 6.5e-09 35.7 0.0 1.9 2 0 0 2 2 2 1 RimK-like ATP-grasp domain ATP-grasp_3 PF02655.14 EDO18706.1 - 0.022 14.8 0.3 0.17 11.9 0.0 2.4 2 1 0 2 2 2 0 ATP-grasp domain Utp21 PF04192.12 EDO18707.1 - 2.8e-73 246.3 0.6 4.3e-73 245.7 0.6 1.2 1 0 0 1 1 1 1 Utp21 specific WD40 associated putative domain ANAPC4_WD40 PF12894.7 EDO18707.1 - 1.3e-19 70.3 0.2 5.1e-06 26.7 0.0 5.6 3 2 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EDO18707.1 - 4.9e-13 49.3 17.1 1.2e-06 29.1 0.3 7.8 8 0 0 8 8 8 2 WD domain, G-beta repeat eIF2A PF08662.11 EDO18707.1 - 2e-06 27.8 1.5 0.032 14.1 0.0 4.4 2 2 1 4 4 4 2 Eukaryotic translation initiation factor eIF2A PQQ_2 PF13360.6 EDO18707.1 - 5.3e-05 22.9 0.0 0.00072 19.2 0.0 2.7 2 1 0 2 2 2 1 PQQ-like domain CPSF_A PF03178.15 EDO18707.1 - 0.0008 18.8 0.2 0.094 12.0 0.0 2.9 3 0 0 3 3 3 1 CPSF A subunit region Cytochrom_D1 PF02239.16 EDO18707.1 - 0.0035 15.9 0.0 0.012 14.1 0.0 1.8 2 0 0 2 2 2 1 Cytochrome D1 heme domain PQQ_3 PF13570.6 EDO18707.1 - 0.017 15.6 0.2 2.1 8.9 0.0 3.6 3 0 0 3 3 3 0 PQQ-like domain Frtz PF11768.8 EDO18707.1 - 0.067 11.5 0.0 0.17 10.1 0.0 1.6 1 0 0 1 1 1 0 WD repeat-containing and planar cell polarity effector protein Fritz Vps39_1 PF10366.9 EDO18708.1 - 9.3e-30 103.1 2.9 9.3e-30 103.1 2.9 3.7 3 0 0 3 3 3 1 Vacuolar sorting protein 39 domain 1 Vps39_2 PF10367.9 EDO18708.1 - 9.2e-14 51.8 0.2 9.2e-14 51.8 0.2 2.7 3 0 0 3 3 3 1 Vacuolar sorting protein 39 domain 2 Clathrin PF00637.20 EDO18708.1 - 0.00023 21.1 18.6 0.025 14.5 0.6 4.9 3 2 2 5 5 5 2 Region in Clathrin and VPS TerY_C PF15616.6 EDO18708.1 - 0.1 12.7 0.4 0.4 10.8 0.1 2.1 2 0 0 2 2 2 0 TerY-C metal binding domain HEPN_Apea PF18739.1 EDO18708.1 - 0.16 12.4 6.2 0.11 12.9 1.1 3.4 2 0 0 2 2 2 0 Apea-like HEPN Zn-C2H2_12 PF18112.1 EDO18708.1 - 0.58 10.7 2.4 3.4 8.2 0.8 2.8 2 0 0 2 2 2 0 Autophagy receptor zinc finger-C2H2 domain Imm3 PF14425.6 EDO18708.1 - 1.8 8.6 7.0 18 5.4 0.5 3.6 3 1 0 3 3 3 0 Immunity protein Imm3 F-box-like_2 PF13013.6 EDO18708.1 - 2.2 8.3 5.1 82 3.2 0.1 4.0 4 0 0 4 4 4 0 F-box-like domain Rxt3 PF08642.10 EDO18710.1 - 1.7e-26 93.4 0.0 2.3e-25 89.8 0.0 2.3 2 0 0 2 2 2 1 Histone deacetylation protein Rxt3 Ribosomal_L31e PF01198.19 EDO18711.1 - 1.5e-38 130.9 0.7 1.8e-38 130.6 0.7 1.1 1 0 0 1 1 1 1 Ribosomal protein L31e Dus PF01207.17 EDO18712.1 - 5.8e-84 281.8 0.0 7.1e-84 281.5 0.0 1.0 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) ComA PF02679.15 EDO18712.1 - 0.046 13.2 0.0 0.094 12.2 0.0 1.5 1 0 0 1 1 1 0 (2R)-phospho-3-sulfolactate synthase (ComA) BRE1 PF08647.11 EDO18713.1 - 1.2e-27 95.8 17.5 1.2e-27 95.8 17.5 7.1 4 1 3 7 7 6 1 BRE1 E3 ubiquitin ligase zf-C3HC4_3 PF13920.6 EDO18713.1 - 6.1e-07 29.2 10.1 1.1e-06 28.4 10.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EDO18713.1 - 1.2e-06 28.3 9.8 2.2e-06 27.4 9.8 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 EDO18713.1 - 2.2e-05 24.2 11.5 4.2e-05 23.3 11.5 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EDO18713.1 - 3.9e-05 23.5 12.8 7.8e-05 22.6 12.8 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 EDO18713.1 - 6.3e-05 22.8 12.8 0.00014 21.7 12.8 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EDO18713.1 - 0.0023 18.2 11.7 0.0054 17.0 11.7 1.7 1 0 0 1 1 1 1 Ring finger domain zf-C2H2 PF00096.26 EDO18713.1 - 0.0091 16.4 0.2 0.0091 16.4 0.2 3.1 3 0 0 3 3 2 1 Zinc finger, C2H2 type bZIP_1 PF00170.21 EDO18713.1 - 0.014 15.5 1.2 0.014 15.5 1.2 9.4 7 2 3 10 10 9 0 bZIP transcription factor zf-C2H2_jaz PF12171.8 EDO18713.1 - 0.06 13.6 1.9 1.5 9.2 0.1 3.0 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-RING_UBOX PF13445.6 EDO18713.1 - 0.095 12.7 10.8 0.21 11.7 10.8 1.6 1 0 0 1 1 1 0 RING-type zinc-finger zf-C2H2_4 PF13894.6 EDO18713.1 - 0.23 12.4 0.2 0.23 12.4 0.2 3.2 3 0 0 3 3 2 0 C2H2-type zinc finger zf-RING_6 PF14835.6 EDO18713.1 - 0.75 9.7 5.6 1.6 8.7 5.6 1.5 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-RING_4 PF14570.6 EDO18713.1 - 8.8 6.2 9.5 20 5.1 9.5 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-C2H2_aberr PF17017.5 EDO18714.1 - 3.4e-06 27.3 8.8 0.0011 19.1 0.0 3.6 3 1 0 3 3 3 2 Aberrant zinc-finger zf-C2H2_4 PF13894.6 EDO18714.1 - 0.0002 21.9 12.8 0.041 14.7 0.6 3.9 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2 PF00096.26 EDO18714.1 - 0.0016 18.8 19.5 0.014 15.8 1.1 3.9 4 0 0 4 4 4 2 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 EDO18714.1 - 0.0062 16.8 5.3 2.3 8.6 0.1 3.3 2 1 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EDO18714.1 - 0.027 14.8 1.2 2.5 8.6 0.1 3.0 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-C2HE PF16278.5 EDO18714.1 - 0.15 12.5 2.8 0.2 12.1 1.1 2.1 1 1 0 1 1 1 0 C2HE / C2H2 / C2HC zinc-binding finger zf-H2C2_2 PF13465.6 EDO18714.1 - 0.29 11.6 17.8 0.15 12.5 1.1 3.5 3 0 0 3 3 3 0 Zinc-finger double domain Bap31 PF05529.12 EDO18715.1 - 7.4e-39 132.7 3.2 9.2e-39 132.4 3.2 1.1 1 0 0 1 1 1 1 Bap31/Bap29 transmembrane region RIC3 PF15361.6 EDO18715.1 - 0.13 12.6 1.0 0.22 11.9 1.0 1.2 1 0 0 1 1 1 0 Resistance to inhibitors of cholinesterase homologue 3 Bromodomain PF00439.25 EDO18716.1 - 1e-41 140.9 3.5 3.6e-21 75.0 0.3 2.6 2 0 0 2 2 2 2 Bromodomain BET PF17035.5 EDO18716.1 - 1.1e-19 70.3 1.4 3.7e-19 68.6 1.4 2.0 1 0 0 1 1 1 1 Bromodomain extra-terminal - transcription regulation DUF4094 PF13334.6 EDO18716.1 - 0.25 11.8 0.1 0.25 11.8 0.1 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4094) DSHCT PF08148.12 EDO18717.1 - 1.9e-49 167.5 0.2 4e-49 166.4 0.2 1.5 1 0 0 1 1 1 1 DSHCT (NUC185) domain Ski2_N PF17911.1 EDO18717.1 - 1.6e-36 125.1 0.1 4.1e-36 123.8 0.1 1.7 1 0 0 1 1 1 1 Ski2 N-terminal region DEAD PF00270.29 EDO18717.1 - 4.7e-21 75.3 0.0 1.1e-20 74.1 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase rRNA_proc-arch PF13234.6 EDO18717.1 - 3.4e-16 60.0 1.3 3.4e-16 60.0 1.3 2.4 2 0 0 2 2 2 1 rRNA-processing arch domain Helicase_C PF00271.31 EDO18717.1 - 3.1e-08 33.9 0.0 1.8e-07 31.5 0.0 2.4 1 1 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDO18717.1 - 1.1e-06 28.8 0.5 3.9e-06 27.0 0.1 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DUF3502 PF12010.8 EDO18717.1 - 0.035 14.8 0.1 0.15 12.7 0.1 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3502) DUF3053 PF11254.8 EDO18717.1 - 0.078 12.6 0.1 0.63 9.6 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3053) Pox_RNA_Pol_19 PF05320.12 EDO18717.1 - 0.23 11.4 4.8 0.24 11.4 0.0 3.1 3 0 0 3 3 3 0 Poxvirus DNA-directed RNA polymerase 19 kDa subunit HPS3_N PF14761.6 EDO18718.1 - 0.025 14.1 0.6 0.2 11.1 0.5 2.0 1 1 0 1 1 1 0 Hermansky-Pudlak syndrome 3 CAP_assoc_N PF14504.6 EDO18718.1 - 0.025 14.3 0.6 0.04 13.7 0.6 1.3 1 0 0 1 1 1 0 CAP-associated N-terminal COX7C PF02935.16 EDO18720.1 - 9.9e-24 83.4 1.1 2.3e-23 82.2 1.1 1.7 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIIc Iso_dh PF00180.20 EDO18721.1 - 2.9e-68 230.6 0.0 3.5e-68 230.3 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase ATP-synt_10 PF05176.14 EDO18722.1 - 5.6e-95 317.4 1.9 6.4e-95 317.2 1.9 1.0 1 0 0 1 1 1 1 ATP10 protein Arrestin_N PF00339.29 EDO18723.1 - 2.3e-06 27.7 0.0 1.6e-05 25.0 0.0 2.4 2 0 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain CFEM PF05730.11 EDO18724.1 - 7.9e-09 35.5 15.0 2e-08 34.2 15.0 1.7 1 0 0 1 1 1 1 CFEM domain SOG2 PF10428.9 EDO18724.1 - 0.71 9.0 38.6 0.87 8.7 38.6 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein Plasmodium_Vir PF05795.11 EDO18724.1 - 3.8 6.8 17.6 5.8 6.2 17.6 1.3 1 0 0 1 1 1 0 Plasmodium vivax Vir protein GREB1 PF15782.5 EDO18724.1 - 5.4 4.0 24.5 6 3.8 24.5 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer CytB6-F_Fe-S PF08802.10 EDO18725.1 - 0.061 13.4 0.2 0.098 12.7 0.2 1.3 1 0 0 1 1 1 0 Cytochrome B6-F complex Fe-S subunit Peptidase_M16_M PF16187.5 EDO18726.1 - 1.5e-85 286.9 3.6 1.5e-85 286.9 3.6 2.0 2 0 0 2 2 2 1 Middle or third domain of peptidase_M16 Peptidase_M16 PF00675.20 EDO18726.1 - 8.5e-40 136.2 0.3 3e-39 134.4 0.4 1.9 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 EDO18726.1 - 8.3e-31 107.4 2.3 7.5e-17 61.9 0.0 3.0 3 0 0 3 3 3 2 Peptidase M16 inactive domain SAS-6_N PF16531.5 EDO18726.1 - 0.18 12.4 4.0 2 9.0 0.5 3.8 2 1 0 2 2 2 0 Centriolar protein SAS N-terminal Ribosomal_S14 PF00253.21 EDO18727.1 - 6.1e-15 54.7 3.6 6.7e-15 54.6 3.6 1.0 1 0 0 1 1 1 1 Ribosomal protein S14p/S29e zf-C2H2_2 PF12756.7 EDO18728.1 - 2e-30 105.1 7.4 3.8e-29 101.0 0.7 2.7 3 0 0 3 3 3 2 C2H2 type zinc-finger (2 copies) Vac14_Fig4_bd PF11916.8 EDO18729.1 - 8.1e-68 227.6 5.3 8.1e-68 227.6 5.3 1.8 2 0 0 2 2 2 1 Vacuolar protein 14 C-terminal Fig4p binding Vac14_Fab1_bd PF12755.7 EDO18729.1 - 5e-49 164.9 1.4 4.3e-38 129.8 0.0 4.9 5 0 0 5 5 5 3 Vacuolar 14 Fab1-binding region HEAT PF02985.22 EDO18729.1 - 5.1e-11 41.9 0.2 0.0013 18.8 0.0 6.7 7 0 0 7 7 7 2 HEAT repeat CLASP_N PF12348.8 EDO18729.1 - 5e-08 32.8 1.1 0.0039 16.8 0.4 4.5 3 1 1 4 4 4 2 CLASP N terminal HEAT_EZ PF13513.6 EDO18729.1 - 2e-07 31.4 0.2 0.22 12.1 0.1 6.3 7 0 0 7 7 6 1 HEAT-like repeat HEAT_2 PF13646.6 EDO18729.1 - 2.5e-05 24.6 0.0 0.58 10.6 0.0 4.6 5 0 0 5 5 4 1 HEAT repeats Cnd1 PF12717.7 EDO18729.1 - 0.00046 20.3 10.0 0.53 10.3 0.8 4.5 4 1 1 5 5 5 2 non-SMC mitotic condensation complex subunit 1 Rep_fac_C PF08542.11 EDO18729.1 - 0.01 16.2 0.7 40 4.7 0.0 4.5 3 1 0 4 4 4 0 Replication factor C C-terminal domain Sigma70_r2 PF04542.14 EDO18729.1 - 0.015 15.0 0.0 8.8 6.2 0.2 2.5 2 0 0 2 2 2 0 Sigma-70 region 2 DUF3361 PF11841.8 EDO18729.1 - 0.046 13.7 0.1 0.31 11.0 0.0 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF3361) DUF4815 PF16075.5 EDO18729.1 - 0.1 10.9 0.0 0.18 10.0 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4815) Arm PF00514.23 EDO18729.1 - 0.4 10.8 4.6 3.7 7.7 0.0 4.5 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat SWC7 PF17330.2 EDO18730.1 - 1.7e-40 137.1 1.7 2e-40 136.8 1.7 1.1 1 0 0 1 1 1 1 SWR1 chromatin-remodelling complex, sub-unit Swc7 Rad52_Rad22 PF04098.15 EDO18731.1 - 3.2e-18 66.1 0.2 3.8e-18 65.9 0.2 1.1 1 0 0 1 1 1 1 Rad52/22 family double-strand break repair protein tRNA-synt_1 PF00133.22 EDO18732.1 - 1.1e-54 185.8 0.0 3.9e-19 68.4 0.1 6.0 2 1 3 5 5 5 5 tRNA synthetases class I (I, L, M and V) tRNA-synt_1_2 PF13603.6 EDO18732.1 - 1.4e-38 132.3 0.0 2.5e-38 131.5 0.0 1.5 1 0 0 1 1 1 1 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1g PF09334.11 EDO18732.1 - 1.8e-30 106.0 0.6 2.9e-21 75.7 0.0 5.1 4 1 1 5 5 5 4 tRNA synthetases class I (M) tRNA-synt_1e PF01406.19 EDO18732.1 - 0.00048 19.6 0.0 0.025 14.0 0.0 2.3 2 0 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1d PF00750.19 EDO18732.1 - 0.015 14.3 0.0 0.023 13.6 0.0 1.2 1 0 0 1 1 1 0 tRNA synthetases class I (R) zf-ribbon_3 PF13248.6 EDO18732.1 - 0.59 9.6 3.2 4.9 6.7 0.2 2.4 2 0 0 2 2 2 0 zinc-ribbon domain adh_short PF00106.25 EDO18734.1 - 1.3e-17 63.9 0.0 2.4e-17 63.0 0.0 1.4 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EDO18734.1 - 9e-09 35.2 0.0 1.5e-08 34.5 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EDO18734.1 - 2.8e-08 33.9 0.0 4.1e-08 33.3 0.0 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EDO18734.1 - 0.0019 17.7 0.0 0.0026 17.3 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EDO18734.1 - 0.13 11.7 0.0 0.21 11.0 0.0 1.3 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Gaa1 PF04114.14 EDO18735.1 - 0.033 13.2 0.3 0.039 13.0 0.3 1.0 1 0 0 1 1 1 0 Gaa1-like, GPI transamidase component CAF1 PF04857.20 EDO18736.1 - 5.1e-14 52.2 3.0 1.5e-08 34.2 0.0 2.1 1 1 1 2 2 2 2 CAF1 family ribonuclease SUIM_assoc PF16619.5 EDO18736.1 - 0.15 12.1 0.0 0.15 12.1 0.0 2.6 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 NTF2 PF02136.20 EDO18737.1 - 1.3e-21 77.4 1.4 3.9e-21 75.8 0.1 2.3 2 0 0 2 2 2 1 Nuclear transport factor 2 (NTF2) domain RRM_1 PF00076.22 EDO18737.1 - 0.03 14.1 0.1 0.08 12.8 0.1 1.7 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Y_phosphatase2 PF03162.13 EDO18738.1 - 2e-37 128.3 2.1 5e-36 123.8 2.1 2.4 1 1 0 1 1 1 1 Tyrosine phosphatase family Sacchrp_dh_C PF16653.5 EDO18739.1 - 1.2e-93 314.1 0.0 1.7e-93 313.6 0.0 1.2 1 0 0 1 1 1 1 Saccharopine dehydrogenase C-terminal domain Sacchrp_dh_NADP PF03435.18 EDO18739.1 - 2.1e-24 86.2 0.2 3.2e-24 85.7 0.2 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Shikimate_DH PF01488.20 EDO18739.1 - 9.5e-08 32.2 0.1 2.1e-07 31.1 0.1 1.6 1 1 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase NAD_binding_10 PF13460.6 EDO18739.1 - 3.2e-07 30.4 0.0 4.9e-07 29.8 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding 3Beta_HSD PF01073.19 EDO18739.1 - 0.016 14.2 0.0 0.024 13.6 0.0 1.3 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family ZNRF_3_ecto PF18212.1 EDO18739.1 - 0.12 12.4 0.0 0.21 11.6 0.0 1.3 1 0 0 1 1 1 0 ZNRF-3 Ectodomain IlvN PF07991.12 EDO18739.1 - 0.2 11.2 0.1 0.59 9.7 0.0 1.8 2 0 0 2 2 2 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain Mso1_Sec1_bdg PF14475.6 EDO18740.1 - 8e-17 60.6 0.0 1.6e-16 59.6 0.0 1.5 1 0 0 1 1 1 1 Sec1-binding region of Mso1 CDC50 PF03381.15 EDO18741.1 - 1.5e-88 297.0 0.9 1.8e-88 296.7 0.9 1.1 1 0 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family TMIE PF16038.5 EDO18741.1 - 0.061 13.2 0.0 8.9 6.2 0.0 2.5 2 0 0 2 2 2 0 TMIE protein Not1 PF04054.15 EDO18742.1 - 2.5e-73 247.1 7.2 9.1e-73 245.3 7.2 2.0 1 0 0 1 1 1 1 CCR4-Not complex component, Not1 CNOT1_CAF1_bind PF16415.5 EDO18742.1 - 5.2e-66 222.2 8.6 5.2e-66 222.2 8.6 3.9 3 0 0 3 3 3 1 CCR4-NOT transcription complex subunit 1 CAF1-binding domain CNOT1_HEAT_N PF16419.5 EDO18742.1 - 2.5e-57 194.2 8.7 2.5e-57 194.2 8.7 4.4 5 1 0 5 5 5 1 CCR4-NOT transcription complex subunit 1 HEAT repeat CNOT1_TTP_bind PF16417.5 EDO18742.1 - 1e-29 103.1 8.8 1e-29 103.1 8.8 2.5 2 0 0 2 2 2 1 CCR4-NOT transcription complex subunit 1 TTP binding domain DUF3819 PF12842.7 EDO18742.1 - 0.059 13.3 1.3 0.27 11.2 0.0 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF3819) Pkinase PF00069.25 EDO18743.1 - 3.4e-79 265.9 0.1 8.1e-79 264.7 0.1 1.7 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO18743.1 - 1.2e-33 116.5 0.1 4.5e-32 111.3 0.1 2.4 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDO18743.1 - 1.8e-08 34.0 0.2 3.2e-05 23.4 0.0 2.6 1 1 1 2 2 2 2 Kinase-like APH PF01636.23 EDO18743.1 - 0.088 12.7 0.0 9.6 6.0 0.0 2.2 1 1 1 2 2 2 0 Phosphotransferase enzyme family Trm112p PF03966.16 EDO18744.1 - 1.1e-17 64.4 0.0 1.5e-17 64.0 0.0 1.2 1 0 0 1 1 1 1 Trm112p-like protein Arc_PepC PF06819.11 EDO18744.1 - 0.16 12.1 0.0 0.21 11.7 0.0 1.2 1 0 0 1 1 1 0 Archaeal Peptidase A24 C-terminal Domain HA2 PF04408.23 EDO18745.1 - 0.3 11.4 0.0 0.3 11.4 0.0 2.5 3 0 0 3 3 3 0 Helicase associated domain (HA2) DUF866 PF05907.13 EDO18746.1 - 2.1e-45 154.4 6.3 3e-45 153.9 6.3 1.2 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF866) zinc_ribbon_6 PF14599.6 EDO18746.1 - 0.026 14.5 3.9 0.25 11.4 0.2 2.7 2 1 1 3 3 3 0 Zinc-ribbon Flocculin_t3 PF13928.6 EDO18747.1 - 3.3e-19 69.1 109.3 3.5e-07 30.6 15.3 19.8 9 3 4 13 13 13 5 Flocculin type 3 repeat zf_PR_Knuckle PF18445.1 EDO18747.1 - 0.71 9.7 16.0 23 4.9 0.2 5.7 5 0 0 5 5 5 0 PR zinc knuckle motif zf-LYAR PF08790.11 EDO18748.1 - 2.4e-13 49.7 9.2 5.4e-13 48.6 9.2 1.6 1 0 0 1 1 1 1 LYAR-type C2HC zinc finger Spt20 PF12090.8 EDO18748.1 - 0.0039 16.8 17.6 0.0049 16.5 17.6 1.2 1 0 0 1 1 1 1 Spt20 family DUF3306 PF11748.8 EDO18748.1 - 0.092 13.6 8.7 0.12 13.2 8.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3306) DUF4809 PF16067.5 EDO18748.1 - 0.13 12.5 3.4 0.23 11.7 3.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4809) DUF2201_N PF13203.6 EDO18748.1 - 0.22 11.1 6.2 0.24 11.0 6.2 1.1 1 0 0 1 1 1 0 Putative metallopeptidase domain PPL5 PF18168.1 EDO18748.1 - 0.24 10.7 7.2 0.3 10.3 7.2 1.2 1 0 0 1 1 1 0 Prim-pol family 5 XPA_N PF01286.18 EDO18748.1 - 0.26 11.4 4.0 6.2 7.0 0.2 2.4 2 0 0 2 2 2 0 XPA protein N-terminal zf-C2H2_4 PF13894.6 EDO18748.1 - 0.3 12.0 7.4 1.2 10.2 0.4 2.5 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2 PF00096.26 EDO18748.1 - 0.61 10.7 6.7 2 9.0 1.7 2.5 1 1 1 2 2 2 0 Zinc finger, C2H2 type FTZ PF03867.14 EDO18748.1 - 0.63 9.5 14.1 0.82 9.2 14.1 1.1 1 0 0 1 1 1 0 Fushi tarazu (FTZ), N-terminal region Presenilin PF01080.17 EDO18748.1 - 0.94 8.2 11.1 1 8.1 11.1 1.1 1 0 0 1 1 1 0 Presenilin DUF3573 PF12097.8 EDO18748.1 - 1.4 7.7 5.2 1.7 7.4 5.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) CDC45 PF02724.14 EDO18748.1 - 2 6.6 12.9 2.3 6.4 12.9 1.0 1 0 0 1 1 1 0 CDC45-like protein Band_3_cyto PF07565.13 EDO18748.1 - 3.1 7.5 9.1 4.7 6.9 9.1 1.3 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Hid1 PF12722.7 EDO18748.1 - 3.9 5.5 9.8 3.9 5.5 9.8 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Neur_chan_memb PF02932.16 EDO18748.1 - 6.8 6.7 11.6 8.3 6.4 11.6 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF4175 PF13779.6 EDO18748.1 - 7.1 4.4 16.1 8.2 4.2 16.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) SID-1_RNA_chan PF13965.6 EDO18748.1 - 9.7 4.5 6.8 10 4.4 6.8 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Csm1_N PF18504.1 EDO18749.1 - 1.3e-22 79.9 6.9 1.3e-22 79.9 6.9 1.9 2 0 0 2 2 2 1 Csm1 N-terminal domain Csm1 PF12539.8 EDO18749.1 - 1.1e-21 77.3 0.3 4.5e-21 75.3 0.0 2.0 2 1 0 2 2 2 1 Chromosome segregation protein Csm1/Pcs1 Lebercilin PF15619.6 EDO18749.1 - 0.00019 21.2 2.0 0.00019 21.2 2.0 1.7 2 0 0 2 2 2 1 Ciliary protein causing Leber congenital amaurosis disease Spc29 PF17082.5 EDO18749.1 - 0.0018 18.2 1.5 0.0023 17.8 1.5 1.3 1 0 0 1 1 1 1 Spindle Pole Component 29 DUF16 PF01519.16 EDO18749.1 - 0.016 15.7 2.5 0.016 15.7 2.5 2.1 2 1 0 2 2 2 0 Protein of unknown function DUF16 Cluap1 PF10234.9 EDO18749.1 - 0.016 14.6 4.0 0.13 11.7 2.3 2.1 2 0 0 2 2 2 0 Clusterin-associated protein-1 COG2 PF06148.11 EDO18749.1 - 0.02 15.0 1.8 0.023 14.8 0.6 1.7 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 CEP209_CC5 PF16574.5 EDO18749.1 - 0.02 15.1 1.6 0.02 15.1 1.6 2.0 2 0 0 2 2 2 0 Coiled-coil region of centrosome protein CE290 Fez1 PF06818.15 EDO18749.1 - 0.033 14.7 4.3 0.053 14.0 4.4 1.4 1 1 0 1 1 1 0 Fez1 DUF1664 PF07889.12 EDO18749.1 - 0.19 11.7 2.9 0.4 10.7 2.9 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) DUF720 PF05302.11 EDO18749.1 - 1.3 8.8 5.6 0.24 11.2 0.8 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF720) TMF_DNA_bd PF12329.8 EDO18749.1 - 3 7.9 16.1 0.072 13.1 8.9 2.0 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding WD40 PF00400.32 EDO18750.1 - 1.4e-49 165.0 16.4 1.3e-08 35.3 0.0 7.5 7 0 0 7 7 7 7 WD domain, G-beta repeat Tup_N PF08581.10 EDO18750.1 - 2e-29 101.7 12.8 2e-29 101.7 12.8 1.8 2 0 0 2 2 2 1 Tup N-terminal ANAPC4_WD40 PF12894.7 EDO18750.1 - 3.3e-15 56.2 0.0 2.7e-05 24.4 0.0 5.4 3 1 3 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EDO18750.1 - 1.2e-05 24.2 0.7 0.65 8.6 0.0 4.1 3 1 2 5 5 5 2 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 EDO18750.1 - 0.00042 19.4 0.0 0.74 8.7 0.0 3.8 2 1 1 4 4 4 1 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 EDO18750.1 - 0.0011 18.3 0.0 0.74 9.1 0.0 3.4 2 1 2 4 4 4 2 WD40-like domain Atg14 PF10186.9 EDO18750.1 - 0.17 11.0 12.3 0.29 10.2 12.3 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 RE_HindIII PF09518.10 EDO18750.1 - 1.1 8.4 7.2 1.8 7.7 7.2 1.3 1 0 0 1 1 1 0 HindIII restriction endonuclease CCDC-167 PF15188.6 EDO18750.1 - 3.3 8.1 7.1 10 6.5 7.1 1.8 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 167 MDD_C PF18376.1 EDO18751.1 - 1.5e-69 233.5 0.0 2.2e-69 233.0 0.0 1.2 1 0 0 1 1 1 1 Mevalonate 5-diphosphate decarboxylase C-terminal domain GHMP_kinases_N PF00288.26 EDO18751.1 - 2.6e-10 40.4 0.9 8.1e-10 38.8 0.9 1.9 2 0 0 2 2 2 1 GHMP kinases N terminal domain DUF1819 PF08849.11 EDO18751.1 - 0.12 12.2 1.1 0.47 10.2 0.1 2.5 2 1 1 3 3 3 0 Putative inner membrane protein (DUF1819) UbiA PF01040.18 EDO18752.1 - 2.6e-45 154.7 13.6 3.6e-45 154.2 13.6 1.1 1 0 0 1 1 1 1 UbiA prenyltransferase family Sof1 PF04158.14 EDO18753.1 - 0.043 14.1 1.5 0.083 13.2 1.5 1.4 1 0 0 1 1 1 0 Sof1-like domain Med12 PF09497.10 EDO18755.1 - 2.2e-22 79.1 0.3 5.8e-22 77.8 0.3 1.8 1 0 0 1 1 1 1 Transcription mediator complex subunit Med12 CAF1-p150_C2 PF15539.6 EDO18755.1 - 0.14 11.6 0.0 0.26 10.7 0.0 1.3 1 0 0 1 1 1 0 CAF1 complex subunit p150, region binding to CAF1-p60 at C-term DEAD PF00270.29 EDO18756.1 - 3.8e-47 160.3 0.3 6.7e-47 159.5 0.3 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDO18756.1 - 2.3e-21 76.2 3.1 2.8e-21 75.9 0.3 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDO18756.1 - 3.3e-11 43.5 0.2 3.3e-11 43.5 0.2 2.4 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit Flavi_DEAD PF07652.14 EDO18756.1 - 9.7e-05 22.4 0.1 0.044 13.7 0.0 2.7 1 1 1 2 2 2 2 Flavivirus DEAD domain AAA_22 PF13401.6 EDO18756.1 - 0.0016 18.7 0.5 0.0056 17.0 0.5 1.9 1 1 0 1 1 1 1 AAA domain DUF3530 PF12048.8 EDO18756.1 - 1.2 8.4 6.2 21 4.4 5.5 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3530) BUD22 PF09073.10 EDO18756.1 - 4.8 6.4 27.4 9.1 5.5 27.4 1.4 1 0 0 1 1 1 0 BUD22 Nop14 PF04147.12 EDO18756.1 - 5.8 5.0 24.0 11 4.1 24.0 1.4 1 0 0 1 1 1 0 Nop14-like family UvrD-helicase PF00580.21 EDO18756.1 - 7.3 6.0 14.2 0.2 11.2 1.8 2.5 2 1 0 2 2 2 0 UvrD/REP helicase N-terminal domain CDC45 PF02724.14 EDO18756.1 - 9.6 4.4 16.9 15 3.7 16.9 1.3 1 0 0 1 1 1 0 CDC45-like protein Ribosomal_S19 PF00203.21 EDO18757.1 - 2.6e-24 84.9 0.0 3.1e-24 84.6 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S19 PP2C PF00481.21 EDO18758.1 - 1.6e-31 109.9 0.0 1.6e-28 100.1 0.0 2.4 2 0 0 2 2 2 2 Protein phosphatase 2C PP2C_2 PF13672.6 EDO18758.1 - 0.016 14.9 0.0 0.029 14.0 0.0 1.4 1 0 0 1 1 1 0 Protein phosphatase 2C SpoIIE PF07228.12 EDO18758.1 - 0.17 11.8 0.0 0.27 11.1 0.0 1.3 1 0 0 1 1 1 0 Stage II sporulation protein E (SpoIIE) Ribosom_S12_S23 PF00164.25 EDO18759.1 - 1.2e-32 111.8 0.4 2.1e-32 111.1 0.4 1.3 1 0 0 1 1 1 1 Ribosomal protein S12/S23 PAT1 PF09770.9 EDO18760.1 - 9.2e-95 318.7 62.1 3.3e-48 164.7 62.7 3.5 1 1 1 2 2 2 2 Topoisomerase II-associated protein PAT1 DUF3215 PF11503.8 EDO18762.1 - 1e-30 105.4 0.6 1.1e-30 105.2 0.6 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3215) LodA_N PF17990.1 EDO18762.1 - 0.12 12.2 0.1 0.14 12.1 0.1 1.0 1 0 0 1 1 1 0 L-Lysine epsilon oxidase N-terminal Imm61 PF15598.6 EDO18762.1 - 0.18 11.7 0.0 0.25 11.2 0.0 1.3 1 1 0 1 1 1 0 Immunity protein 61 LMBR1 PF04791.16 EDO18763.1 - 1e-24 87.4 35.8 1.6e-24 86.8 35.8 1.2 1 0 0 1 1 1 1 LMBR1-like membrane protein Glucosamine_iso PF01182.20 EDO18764.1 - 6.3e-53 180.0 0.0 1.3e-52 178.9 0.0 1.4 2 0 0 2 2 2 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase Chorismate_bind PF00425.18 EDO18765.1 - 1.2e-66 225.0 0.0 1.9e-66 224.3 0.0 1.3 1 0 0 1 1 1 1 chorismate binding enzyme GATase PF00117.28 EDO18765.1 - 2.5e-26 92.6 0.0 4.1e-26 91.9 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Anth_synt_I_N PF04715.13 EDO18765.1 - 2.1e-18 66.9 0.2 1.1e-17 64.5 0.0 2.3 2 0 0 2 2 2 1 Anthranilate synthase component I, N terminal region Peptidase_C26 PF07722.13 EDO18765.1 - 1.5e-07 31.4 0.0 2.8e-07 30.5 0.0 1.4 1 0 0 1 1 1 1 Peptidase C26 Pkinase PF00069.25 EDO18766.1 - 4.3e-62 209.9 0.0 1.1e-61 208.6 0.0 1.7 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO18766.1 - 3.6e-34 118.2 0.1 3e-26 92.3 0.1 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 EDO18766.1 - 0.00036 20.0 0.1 0.0041 16.5 0.0 2.2 2 0 0 2 2 2 1 Kinase-like Seadorna_VP7 PF07387.11 EDO18766.1 - 0.0074 15.4 0.0 0.026 13.6 0.0 1.9 1 0 0 1 1 1 1 Seadornavirus VP7 Pkinase_fungal PF17667.1 EDO18766.1 - 0.088 11.6 0.0 0.088 11.6 0.0 1.7 2 0 0 2 2 2 0 Fungal protein kinase APH PF01636.23 EDO18766.1 - 0.19 11.6 0.0 0.37 10.7 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family WD40 PF00400.32 EDO18767.1 - 3.7e-60 198.5 37.6 1.7e-11 44.4 0.1 9.0 8 1 0 8 8 8 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDO18767.1 - 5.1e-20 71.6 7.2 7e-06 26.3 0.1 5.6 2 2 3 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain NLE PF08154.12 EDO18767.1 - 1e-09 38.8 0.0 1.9e-09 37.9 0.0 1.5 1 0 0 1 1 1 1 NLE (NUC135) domain eIF2A PF08662.11 EDO18767.1 - 4.3e-08 33.3 3.5 0.00038 20.4 0.0 3.8 2 2 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 EDO18767.1 - 6.7e-06 25.0 10.1 0.063 11.9 0.0 5.7 4 2 2 6 6 6 2 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 EDO18767.1 - 1.2e-05 24.5 0.4 0.3 10.0 0.1 4.0 2 2 1 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nbas_N PF15492.6 EDO18767.1 - 0.0039 16.6 1.6 0.71 9.2 0.1 3.1 2 1 1 3 3 3 1 Neuroblastoma-amplified sequence, N terminal Frtz PF11768.8 EDO18767.1 - 0.006 15.0 0.0 0.27 9.5 0.0 2.8 3 0 0 3 3 3 1 WD repeat-containing and planar cell polarity effector protein Fritz WD40_like PF17005.5 EDO18767.1 - 0.0068 15.8 0.0 2.5 7.3 0.0 3.7 4 1 0 4 4 4 1 WD40-like domain PD40 PF07676.12 EDO18767.1 - 0.011 15.6 0.1 10 6.2 0.0 3.3 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 EDO18767.1 - 0.014 13.9 0.1 0.97 7.9 0.0 3.1 3 1 0 3 3 3 0 Cytochrome D1 heme domain PALB2_WD40 PF16756.5 EDO18767.1 - 0.45 9.4 6.7 0.44 9.4 0.4 3.2 3 1 1 4 4 4 0 Partner and localizer of BRCA2 WD40 domain Glyco_transf_22 PF03901.17 EDO18768.1 - 3.1e-26 92.6 24.5 4.4e-26 92.1 24.5 1.2 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family Pro_isomerase PF00160.21 EDO18769.1 - 1.5e-28 100.1 0.0 2.4e-28 99.4 0.0 1.3 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Lipase_3 PF01764.25 EDO18770.1 - 1.3e-08 34.8 0.0 2.5e-08 33.9 0.0 1.4 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_6 PF12697.7 EDO18770.1 - 0.011 16.4 0.0 0.019 15.6 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family UPF0227 PF05728.12 EDO18770.1 - 0.015 15.3 0.0 0.028 14.4 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0227) Hydrolase_4 PF12146.8 EDO18770.1 - 0.064 12.5 0.0 0.13 11.5 0.0 1.4 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Neuropep_like PF15161.6 EDO18770.1 - 0.099 12.3 0.0 0.22 11.2 0.0 1.5 1 0 0 1 1 1 0 Neuropeptide-like Phos_pyr_kin PF08543.12 EDO18771.1 - 1.3e-08 34.5 0.0 1.9e-08 34.0 0.0 1.3 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase Forkhead PF00250.18 EDO18772.1 - 2.9e-35 120.4 0.1 1.1e-34 118.5 0.1 2.1 1 0 0 1 1 1 1 Forkhead domain G10 PF01125.17 EDO18773.1 - 4.5e-60 201.7 12.1 5.2e-60 201.5 12.1 1.0 1 0 0 1 1 1 1 G10 protein Histone_HNS PF00816.21 EDO18773.1 - 0.065 14.1 0.3 0.096 13.5 0.3 1.3 1 0 0 1 1 1 0 H-NS histone family Stap_Strp_tox_C PF02876.17 EDO18773.1 - 0.069 13.5 1.6 0.11 12.8 1.6 1.3 1 0 0 1 1 1 0 Staphylococcal/Streptococcal toxin, beta-grasp domain ANTH PF07651.16 EDO18774.1 - 4.8e-59 199.6 0.2 4.8e-59 199.6 0.2 2.0 2 0 0 2 2 2 1 ANTH domain SPT16 PF08644.11 EDO18774.1 - 0.015 15.4 2.8 0.029 14.5 2.8 1.4 1 0 0 1 1 1 0 FACT complex subunit (SPT16/CDC68) Bap31_Bap29_C PF18035.1 EDO18774.1 - 0.042 13.9 0.8 0.087 12.8 0.8 1.5 1 0 0 1 1 1 0 Bap31/Bap29 cytoplasmic coiled-coil domain Exonuc_VII_L PF02601.15 EDO18774.1 - 0.05 13.2 5.2 0.091 12.3 5.2 1.5 1 0 0 1 1 1 0 Exonuclease VII, large subunit eIF3_subunit PF08597.10 EDO18774.1 - 0.058 13.3 1.9 0.1 12.5 1.9 1.3 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit OmpH PF03938.14 EDO18774.1 - 0.18 12.1 7.6 0.42 11.0 7.6 1.6 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) TMF_DNA_bd PF12329.8 EDO18774.1 - 0.47 10.5 8.7 1.1 9.3 8.7 1.6 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding CheD PF03975.13 EDO18774.1 - 0.9 9.7 17.3 8.4 6.5 0.5 5.6 1 1 5 6 6 6 0 CheD chemotactic sensory transduction FliJ PF02050.16 EDO18774.1 - 1.3 9.3 12.0 0.34 11.1 8.3 1.9 2 0 0 2 2 2 0 Flagellar FliJ protein DUF3552 PF12072.8 EDO18774.1 - 2.5 7.5 7.7 4.3 6.7 7.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) VASt PF16016.5 EDO18775.1 - 1.4e-15 58.0 2.1 3.3e-15 56.8 2.1 1.6 1 0 0 1 1 1 1 VAD1 Analog of StAR-related lipid transfer domain PH PF00169.29 EDO18775.1 - 8.4e-10 39.1 1.4 3.6e-09 37.1 1.4 2.1 1 0 0 1 1 1 1 PH domain BAR_3 PF16746.5 EDO18775.1 - 0.0013 18.5 0.7 1.8 8.2 0.1 2.9 2 0 0 2 2 2 2 BAR domain of APPL family TPR_1 PF00515.28 EDO18776.1 - 1.6e-10 40.3 0.2 1.1e-07 31.4 0.2 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 EDO18776.1 - 2e-10 40.0 0.0 2e-06 27.5 0.0 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 EDO18776.1 - 9.6e-08 31.7 3.3 6.8e-06 25.9 0.1 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 EDO18776.1 - 1.7e-06 27.6 0.8 1.8e-05 24.3 0.3 2.6 1 1 1 2 2 2 1 TPR repeat TPR_12 PF13424.6 EDO18776.1 - 7.1e-06 26.2 0.2 0.022 15.1 0.0 2.2 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.6 EDO18776.1 - 3.5e-05 23.5 0.1 0.0011 18.9 0.0 2.8 3 0 0 3 3 3 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EDO18776.1 - 4.7e-05 23.5 0.4 0.00079 19.6 0.1 2.1 1 1 1 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 Fis1_TPR_C PF14853.6 EDO18776.1 - 6.2e-05 23.0 0.5 0.0072 16.4 0.1 2.4 2 0 0 2 2 2 1 Fis1 C-terminal tetratricopeptide repeat TPR_6 PF13174.6 EDO18776.1 - 0.00034 21.0 0.3 0.25 12.1 0.0 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.6 EDO18776.1 - 0.00044 20.4 1.1 0.023 15.1 0.0 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 EDO18776.1 - 0.0014 19.1 0.0 0.0019 18.7 0.0 1.3 1 0 0 1 1 1 1 Tetratricopeptide repeat DUF3856 PF12968.7 EDO18776.1 - 0.0079 16.3 0.0 0.061 13.4 0.0 2.1 1 1 0 1 1 1 1 Domain of Unknown Function (DUF3856) MIT PF04212.18 EDO18776.1 - 0.0099 15.9 2.1 0.35 10.9 0.1 2.2 2 0 0 2 2 2 1 MIT (microtubule interacting and transport) domain DUF5113 PF17140.4 EDO18776.1 - 0.041 13.7 4.9 0.44 10.3 4.9 2.3 1 1 0 1 1 1 0 Domain of unknown function (DUF5113) Toprim_N PF08275.11 EDO18776.1 - 0.052 13.6 0.3 0.095 12.8 0.2 1.6 1 1 0 1 1 1 0 DNA primase catalytic core, N-terminal domain TPR_10 PF13374.6 EDO18776.1 - 0.057 13.3 0.0 0.21 11.5 0.0 1.9 2 0 0 2 2 2 0 Tetratricopeptide repeat UPF0029 PF01205.19 EDO18777.1 - 2.7e-33 114.4 0.0 4.1e-33 113.8 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized protein family UPF0029 RWD PF05773.22 EDO18777.1 - 3.4e-07 30.6 1.5 9e-07 29.2 1.5 1.7 1 1 0 1 1 1 1 RWD domain WHAMM-JMY_N PF15920.5 EDO18777.1 - 0.096 12.6 0.0 0.18 11.7 0.0 1.5 1 0 0 1 1 1 0 N-terminal of Junction-mediating and WASP homolog-associated MPP6 PF10175.9 EDO18778.1 - 3e-27 95.7 12.8 3.4e-27 95.5 12.8 1.0 1 0 0 1 1 1 1 M-phase phosphoprotein 6 DUF4710 PF15828.5 EDO18778.1 - 3.1 8.0 9.1 5.3 7.2 7.4 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4710) WD40 PF00400.32 EDO18779.1 - 3.6e-46 154.2 15.1 4.4e-09 36.8 0.1 12.7 13 0 0 13 13 13 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDO18779.1 - 7.7e-34 115.9 0.0 4.9e-05 23.6 0.0 9.6 3 2 8 11 11 11 8 Anaphase-promoting complex subunit 4 WD40 domain Utp12 PF04003.12 EDO18779.1 - 3.9e-23 81.8 0.1 6.5e-23 81.1 0.1 1.4 1 0 0 1 1 1 1 Dip2/Utp12 Family Ge1_WD40 PF16529.5 EDO18779.1 - 2e-07 30.3 3.5 0.17 10.8 0.0 6.4 4 3 3 7 7 7 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nbas_N PF15492.6 EDO18779.1 - 6.9e-05 22.3 0.6 0.63 9.3 0.0 4.3 3 2 0 4 4 4 2 Neuroblastoma-amplified sequence, N terminal PQQ_2 PF13360.6 EDO18779.1 - 0.002 17.7 0.6 0.2 11.2 0.2 3.3 1 1 0 2 2 2 1 PQQ-like domain SGL PF08450.12 EDO18779.1 - 0.0024 17.5 0.1 3.6 7.1 0.1 4.3 3 2 0 3 3 3 1 SMP-30/Gluconolactonase/LRE-like region WD40_3 PF15911.5 EDO18779.1 - 0.0081 16.1 0.0 0.037 14.0 0.0 2.2 1 0 0 1 1 1 1 WD domain, G-beta repeat PALB2_WD40 PF16756.5 EDO18779.1 - 0.015 14.2 0.1 2.5 6.9 0.1 2.5 2 0 0 2 2 2 0 Partner and localizer of BRCA2 WD40 domain Frtz PF11768.8 EDO18779.1 - 0.069 11.5 0.0 8.6 4.5 0.0 3.0 2 1 1 3 3 3 0 WD repeat-containing and planar cell polarity effector protein Fritz Cytochrom_D1 PF02239.16 EDO18779.1 - 0.097 11.2 0.0 15 4.0 0.0 3.3 4 0 0 4 4 4 0 Cytochrome D1 heme domain RAB3GAP2_N PF14655.6 EDO18779.1 - 0.12 11.6 0.1 12 5.0 0.0 3.0 3 1 0 3 3 3 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Proteasome_A_N PF10584.9 EDO18779.1 - 0.17 11.6 0.3 5.4 6.8 0.1 3.0 2 0 0 2 2 2 0 Proteasome subunit A N-terminal signature NOA36 PF06524.12 EDO18779.1 - 1.9 7.7 5.6 0.17 11.2 0.8 1.6 2 0 0 2 2 2 0 NOA36 protein Nop25 PF09805.9 EDO18779.1 - 4.8 7.6 6.9 0.48 10.9 2.4 1.6 2 0 0 2 2 1 0 Nucleolar protein 12 (25kDa) Atx10homo_assoc PF09759.9 EDO18780.1 - 8.4e-39 131.6 1.0 8.4e-39 131.6 1.0 2.5 3 0 0 3 3 3 1 Spinocerebellar ataxia type 10 protein domain SWIB PF02201.18 EDO18781.1 - 0.028 14.3 0.1 0.17 11.8 0.1 2.3 2 0 0 2 2 2 0 SWIB/MDM2 domain Gal4_dimer PF03902.13 EDO18782.1 - 0.018 15.2 0.7 0.032 14.4 0.7 1.4 1 0 0 1 1 1 0 Gal4-like dimerisation domain Ank_5 PF13857.6 EDO18783.1 - 3.3e-16 59.1 0.2 7.1e-11 42.1 0.0 3.2 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 EDO18783.1 - 5.4e-09 36.5 0.1 0.092 13.4 0.0 2.3 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EDO18783.1 - 1.4e-08 35.1 0.1 2.5e-05 24.8 0.1 2.8 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EDO18783.1 - 3.6e-06 26.9 0.1 0.0024 18.2 0.0 3.6 3 0 0 3 3 3 1 Ankyrin repeat Ank PF00023.30 EDO18783.1 - 3.4e-05 24.1 0.1 0.039 14.4 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeat Ribosomal_L19 PF01245.20 EDO18784.1 - 6.5e-09 35.7 0.2 1.2e-08 34.8 0.2 1.4 1 0 0 1 1 1 1 Ribosomal protein L19 HIG_1_N PF04588.13 EDO18785.1 - 0.00012 22.2 0.2 0.00022 21.4 0.2 1.4 1 0 0 1 1 1 1 Hypoxia induced protein conserved region Peptidase_S8 PF00082.22 EDO18786.1 - 3.2e-28 98.8 19.0 1.4e-27 96.7 19.0 2.1 1 1 0 1 1 1 1 Subtilase family CNDH2_C PF16858.5 EDO18786.1 - 0.09 12.6 0.5 0.13 12.1 0.5 1.2 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term Inhibitor_I9 PF05922.16 EDO18786.1 - 0.09 13.5 0.0 0.22 12.2 0.0 1.6 1 0 0 1 1 1 0 Peptidase inhibitor I9 Nop14 PF04147.12 EDO18786.1 - 0.13 10.4 9.3 0.2 9.8 9.3 1.2 1 0 0 1 1 1 0 Nop14-like family DNA_pol_phi PF04931.13 EDO18786.1 - 0.15 10.2 19.7 0.25 9.4 19.7 1.3 1 0 0 1 1 1 0 DNA polymerase phi RXT2_N PF08595.11 EDO18786.1 - 0.16 12.0 11.3 13 5.8 8.6 3.3 3 0 0 3 3 3 0 RXT2-like, N-terminal IFT57 PF10498.9 EDO18786.1 - 0.45 9.4 3.5 0.75 8.7 3.5 1.3 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 CDC45 PF02724.14 EDO18786.1 - 0.51 8.6 7.6 0.95 7.7 7.6 1.4 1 0 0 1 1 1 0 CDC45-like protein TFB6 PF17110.5 EDO18786.1 - 1.6 8.4 4.4 3.3 7.4 4.4 1.4 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH BUD22 PF09073.10 EDO18786.1 - 1.9 7.7 8.3 3.3 7.0 8.3 1.3 1 0 0 1 1 1 0 BUD22 DUF4637 PF15470.6 EDO18786.1 - 3.4 7.4 5.0 8.4 6.1 5.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) Sigma70_ner PF04546.13 EDO18786.1 - 6.4 6.6 12.8 0.69 9.8 7.9 1.8 2 0 0 2 2 2 0 Sigma-70, non-essential region CobT PF06213.12 EDO18786.1 - 7 6.0 9.8 12 5.1 9.8 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT SDA1 PF05285.12 EDO18786.1 - 7.5 5.9 14.4 14 5.0 14.4 1.3 1 0 0 1 1 1 0 SDA1 RNA_pol_3_Rpc31 PF11705.8 EDO18786.1 - 7.8 6.7 20.7 0.084 13.1 12.6 1.7 2 0 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 DUF2722 PF10846.8 EDO18786.1 - 8.5 5.2 7.0 12 4.7 7.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) TRAP_alpha PF03896.16 EDO18786.1 - 9.1 5.4 8.9 20 4.2 8.9 1.5 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit G-patch PF01585.23 EDO18787.1 - 1.3e-09 37.8 0.1 3.5e-09 36.4 0.1 1.8 1 0 0 1 1 1 1 G-patch domain MDM1 PF15501.6 EDO18787.1 - 0.022 14.0 29.0 0.028 13.6 29.0 1.1 1 0 0 1 1 1 0 Nuclear protein MDM1 RR_TM4-6 PF06459.12 EDO18787.1 - 0.14 12.0 28.3 0.24 11.2 28.3 1.5 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 GREB1 PF15782.5 EDO18787.1 - 0.16 9.1 14.1 0.17 9.0 14.1 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer CDC45 PF02724.14 EDO18787.1 - 0.26 9.5 31.9 0.34 9.1 31.9 1.1 1 0 0 1 1 1 0 CDC45-like protein SLC12 PF03522.15 EDO18787.1 - 0.53 9.2 25.5 0.65 9.0 25.5 1.2 1 0 0 1 1 1 0 Solute carrier family 12 Rgp1 PF08737.10 EDO18787.1 - 1.2 8.3 17.1 1.4 8.0 17.1 1.2 1 0 0 1 1 1 0 Rgp1 Neur_chan_memb PF02932.16 EDO18787.1 - 1.8 8.6 12.7 2.5 8.1 12.7 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region ALMT PF11744.8 EDO18787.1 - 3.5 6.4 18.8 4.7 5.9 18.8 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Hid1 PF12722.7 EDO18787.1 - 3.8 5.5 25.7 5.1 5.1 25.7 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein SAPS PF04499.15 EDO18787.1 - 3.9 6.1 23.2 4.8 5.8 23.2 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Glyco_hydro_72 PF03198.14 EDO18788.1 - 7e-144 478.9 11.9 7e-144 478.9 11.9 1.4 2 0 0 2 2 2 1 Glucanosyltransferase X8 PF07983.13 EDO18788.1 - 1.1e-27 96.5 7.4 4.1e-27 94.7 7.4 2.1 1 0 0 1 1 1 1 X8 domain Glyco_hydro_2_C PF02836.17 EDO18788.1 - 8.6e-06 25.1 2.0 2.1e-05 23.8 2.0 1.6 1 1 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Ribosomal_L7Ae PF01248.26 EDO18788.1 - 0.14 11.9 0.1 0.35 10.6 0.1 1.6 1 0 0 1 1 1 0 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family CDK2AP PF09806.9 EDO18788.1 - 3.5 7.6 12.5 9.4 6.2 12.5 1.8 1 0 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein Apt1 PF10351.9 EDO18788.1 - 4.3 6.1 10.5 6 5.6 10.5 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain DUF4614 PF15391.6 EDO18788.1 - 9.8 6.1 15.5 26 4.8 15.5 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) Glucan_synthase PF02364.15 EDO18789.1 - 0 1371.8 11.2 0 1371.8 11.2 1.7 2 0 0 2 2 2 1 1,3-beta-glucan synthase component FKS1_dom1 PF14288.6 EDO18789.1 - 3.2e-43 147.1 3.4 2.5e-42 144.2 3.4 2.5 1 1 0 1 1 1 1 1,3-beta-glucan synthase subunit FKS1, domain-1 Glyco_hydro_17 PF00332.18 EDO18791.1 - 3.3e-09 36.8 0.7 3.3e-09 36.8 0.7 2.0 2 1 0 2 2 2 1 Glycosyl hydrolases family 17 DUF3295 PF11702.8 EDO18791.1 - 0.046 13.1 6.6 0.06 12.7 6.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3295) TFIIA PF03153.13 EDO18791.1 - 0.14 12.1 14.2 0.19 11.7 14.2 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit FAM60A PF15396.6 EDO18791.1 - 0.21 11.6 1.1 0.31 11.0 1.1 1.2 1 0 0 1 1 1 0 Protein Family FAM60A MA3 PF02847.17 EDO18792.1 - 1.6e-19 70.0 1.0 1.4e-18 67.0 0.0 2.7 2 1 1 3 3 3 1 MA3 domain MIF4G PF02854.19 EDO18792.1 - 6.4e-06 25.9 7.6 1.8e-05 24.5 2.2 2.9 2 1 0 2 2 2 1 MIF4G domain APG6_N PF17675.1 EDO18792.1 - 0.0077 16.8 2.2 0.02 15.4 2.2 1.7 1 0 0 1 1 1 1 Apg6 coiled-coil region ParcG PF10274.9 EDO18792.1 - 0.08 13.1 0.7 0.19 11.8 0.7 1.5 1 0 0 1 1 1 0 Parkin co-regulated protein 4HB_MCP_1 PF12729.7 EDO18792.1 - 3.9 7.0 10.0 1.1 8.8 3.1 2.8 3 0 0 3 3 3 0 Four helix bundle sensory module for signal transduction CTP_transf_like PF01467.26 EDO18793.1 - 2.6e-10 40.7 0.0 3.8e-10 40.1 0.0 1.3 1 0 0 1 1 1 1 Cytidylyltransferase-like GATase_6 PF13522.6 EDO18794.1 - 2.5e-14 53.6 0.0 6.3e-14 52.3 0.0 1.7 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.6 EDO18794.1 - 8.6e-11 41.8 0.0 2.2e-10 40.5 0.0 1.8 1 0 0 1 1 1 1 Glutamine amidotransferase domain Pribosyltran PF00156.27 EDO18794.1 - 6.3e-09 35.5 0.0 1.3e-08 34.5 0.0 1.5 1 0 0 1 1 1 1 Phosphoribosyl transferase domain GATase_4 PF13230.6 EDO18794.1 - 4.6e-05 22.5 0.0 8e-05 21.7 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferases class-II Rtt102p PF09510.10 EDO18795.1 - 7.2e-48 162.1 0.7 7.2e-48 162.1 0.7 2.0 2 0 0 2 2 2 1 Rtt102p-like transcription regulator protein OPT PF03169.15 EDO18796.1 - 0.012 14.3 0.0 0.016 13.9 0.0 1.0 1 0 0 1 1 1 0 OPT oligopeptide transporter protein Peptidase_S10 PF00450.22 EDO18797.1 - 1.8e-128 429.6 4.4 2.1e-128 429.3 4.4 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase DUF2406 PF10295.9 EDO18798.1 - 4.1e-28 97.8 1.4 4.9e-28 97.6 0.5 1.6 2 0 0 2 2 2 1 Uncharacterised protein (DUF2406) Ribosomal_L6e_N PF03868.15 EDO18798.1 - 0.022 15.0 1.0 0.039 14.2 1.0 1.4 1 0 0 1 1 1 0 Ribosomal protein L6, N-terminal domain Sec63 PF02889.16 EDO18799.1 - 5.9e-124 412.3 1.4 1e-80 270.6 0.0 2.7 2 0 0 2 2 2 2 Sec63 Brl domain DEAD PF00270.29 EDO18799.1 - 1.4e-50 171.5 1.4 4.6e-26 91.6 1.0 3.6 4 0 0 4 4 4 2 DEAD/DEAH box helicase ResIII PF04851.15 EDO18799.1 - 5.2e-31 108.0 0.2 2.6e-14 53.6 0.0 2.8 3 0 0 3 3 3 2 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EDO18799.1 - 5e-19 68.7 0.5 1.1e-07 32.1 0.0 4.0 3 1 0 3 3 3 2 Helicase conserved C-terminal domain AAA_22 PF13401.6 EDO18799.1 - 6.8e-07 29.6 5.5 0.0083 16.4 0.1 4.6 3 1 0 3 3 3 2 AAA domain AAA PF00004.29 EDO18799.1 - 4.8e-06 27.0 1.4 0.22 11.9 0.0 4.4 3 1 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.6 EDO18799.1 - 4.3e-05 23.9 0.3 0.011 16.0 0.3 2.9 2 0 0 2 2 2 1 AAA domain PhoH PF02562.16 EDO18799.1 - 0.00023 20.7 0.1 0.053 13.0 0.0 2.9 3 0 0 3 3 3 1 PhoH-like protein IstB_IS21 PF01695.17 EDO18799.1 - 0.0026 17.5 0.1 2 8.1 0.0 3.9 4 0 0 4 4 4 1 IstB-like ATP binding protein AAA_11 PF13086.6 EDO18799.1 - 0.02 14.7 0.0 0.47 10.2 0.0 3.0 3 1 1 4 4 4 0 AAA domain Helicase_PWI PF18149.1 EDO18799.1 - 0.029 14.6 0.0 0.11 12.7 0.0 2.0 1 0 0 1 1 1 0 N-terminal helicase PWI domain MotA_ExbB PF01618.16 EDO18799.1 - 0.08 12.7 0.0 0.24 11.1 0.0 1.8 1 0 0 1 1 1 0 MotA/TolQ/ExbB proton channel family TniB PF05621.11 EDO18799.1 - 0.67 9.3 3.2 23 4.3 0.1 3.8 4 0 0 4 4 4 0 Bacterial TniB protein NAC PF01849.18 EDO18800.1 - 1e-21 76.6 0.3 2.3e-21 75.5 0.3 1.6 1 0 0 1 1 1 1 NAC domain UBA_4 PF14555.6 EDO18800.1 - 0.082 12.7 0.0 0.19 11.6 0.0 1.6 1 0 0 1 1 1 0 UBA-like domain Ribosomal_L30 PF00327.20 EDO18800.1 - 0.11 12.4 0.2 0.28 11.1 0.2 1.6 1 0 0 1 1 1 0 Ribosomal protein L30p/L7e FlaC_arch PF05377.11 EDO18800.1 - 0.12 12.8 1.9 0.16 12.3 0.5 1.9 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) DUF4665 PF15679.5 EDO18800.1 - 7.5 7.2 10.6 0.3 11.7 0.6 2.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4665) zinc_ribbon_10 PF10058.9 EDO18801.1 - 4.5e-12 45.5 0.2 7.9e-12 44.7 0.2 1.4 1 0 0 1 1 1 1 Predicted integral membrane zinc-ribbon metal-binding protein Zn_Tnp_IS1595 PF12760.7 EDO18801.1 - 0.0023 17.9 1.3 0.0044 17.0 1.3 1.4 1 0 0 1 1 1 1 Transposase zinc-ribbon domain zf-H2C2_2 PF13465.6 EDO18801.1 - 0.016 15.6 3.7 0.63 10.6 0.3 2.4 2 0 0 2 2 2 0 Zinc-finger double domain zf-C4H2 PF10146.9 EDO18801.1 - 0.018 15.4 2.2 0.061 13.6 0.4 2.1 2 0 0 2 2 2 0 Zinc finger-containing protein Zn-ribbon_8 PF09723.10 EDO18801.1 - 0.018 15.1 1.9 0.046 13.8 1.8 1.7 1 1 0 1 1 1 0 Zinc ribbon domain zinc_ribbon_4 PF13717.6 EDO18801.1 - 0.027 14.4 2.2 0.085 12.8 2.2 1.8 1 1 0 1 1 1 0 zinc-ribbon domain zf_UBZ PF18439.1 EDO18801.1 - 0.038 13.6 2.0 3.6 7.3 0.2 2.4 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger NBP1 PF08537.10 EDO18801.1 - 0.039 13.4 9.2 0.28 10.6 7.9 2.0 2 0 0 2 2 2 0 Fungal Nap binding protein NBP1 DUF2757 PF10955.8 EDO18801.1 - 0.042 14.1 0.7 0.32 11.3 0.0 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2757) Desulfoferrod_N PF06397.12 EDO18801.1 - 0.094 12.4 0.2 0.24 11.1 0.2 1.6 1 0 0 1 1 1 0 Desulfoferrodoxin, N-terminal domain zf-ribbon_3 PF13248.6 EDO18801.1 - 0.14 11.7 4.6 0.18 11.2 0.2 2.3 2 0 0 2 2 2 0 zinc-ribbon domain HypA PF01155.19 EDO18801.1 - 0.14 12.1 0.1 0.3 11.1 0.1 1.5 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DUF3797 PF12677.7 EDO18801.1 - 0.15 12.0 2.4 0.39 10.7 0.5 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3797) zf-HIT PF04438.16 EDO18801.1 - 0.19 11.6 3.0 1.1 9.2 0.4 2.2 2 0 0 2 2 2 0 HIT zinc finger YhfH PF14149.6 EDO18801.1 - 0.28 11.2 2.3 0.29 11.1 0.3 2.0 2 0 0 2 2 2 0 YhfH-like protein zf-Mss51 PF13824.6 EDO18801.1 - 0.45 10.6 4.1 0.89 9.7 0.9 2.8 3 0 0 3 3 2 0 Zinc-finger of mitochondrial splicing suppressor 51 zf-C2H2 PF00096.26 EDO18801.1 - 0.86 10.2 4.5 65 4.3 0.6 3.3 3 0 0 3 3 3 0 Zinc finger, C2H2 type TF_Zn_Ribbon PF08271.12 EDO18801.1 - 2.8 7.5 7.8 1.4 8.5 4.2 2.4 2 1 0 2 2 2 0 TFIIB zinc-binding zinc_ribbon_2 PF13240.6 EDO18801.1 - 3.2 7.6 7.0 1.1 9.1 0.7 2.5 2 0 0 2 2 2 0 zinc-ribbon domain HIP1_clath_bdg PF16515.5 EDO18801.1 - 7.5 7.2 8.6 5.2 7.7 5.1 2.0 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 zf-ACC PF17848.1 EDO18801.1 - 8.3 6.6 9.3 2 8.5 0.2 2.7 2 0 0 2 2 2 0 Acetyl-coA carboxylase zinc finger domain Ctf8 PF09696.10 EDO18802.1 - 8.8e-22 78.0 0.4 1.4e-15 57.9 0.0 2.1 1 1 1 2 2 2 2 Ctf8 Glyco_hydro_47 PF01532.20 EDO18803.1 - 9.7e-144 479.7 0.6 1.1e-143 479.5 0.6 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Cys_Met_Meta_PP PF01053.20 EDO18804.1 - 5.6e-25 87.7 0.0 1.5e-24 86.2 0.0 1.6 2 0 0 2 2 2 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 EDO18804.1 - 1.2e-05 24.6 0.0 2.3e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II Methyltransf_16 PF10294.9 EDO18805.1 - 6.3e-22 78.1 0.3 1.1e-21 77.3 0.3 1.4 1 0 0 1 1 1 1 Lysine methyltransferase MTS PF05175.14 EDO18805.1 - 0.0073 15.9 0.0 0.013 15.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_12 PF08242.12 EDO18805.1 - 0.025 15.3 0.1 0.054 14.2 0.1 1.6 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.6 EDO18805.1 - 0.039 13.8 0.0 0.06 13.2 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_25 PF13649.6 EDO18805.1 - 0.12 13.1 0.0 0.24 12.1 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Zn_clus PF00172.18 EDO18806.1 - 4.9e-07 29.8 10.9 1.2e-06 28.6 10.9 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Septin PF00735.18 EDO18807.1 - 2.4e-106 355.2 0.7 2.8e-106 354.9 0.7 1.0 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 EDO18807.1 - 4.7e-10 39.5 0.1 1.1e-09 38.3 0.1 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EDO18807.1 - 1.4e-08 34.5 0.5 2.4e-06 27.2 0.2 2.2 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EDO18807.1 - 2e-07 31.1 0.4 1.8e-06 28.0 0.2 2.1 2 0 0 2 2 2 1 RsgA GTPase AIG1 PF04548.16 EDO18807.1 - 1.3e-05 24.6 0.2 3.4e-05 23.3 0.2 1.7 1 1 0 1 1 1 1 AIG1 family Dynamin_N PF00350.23 EDO18807.1 - 3.5e-05 23.9 0.4 0.056 13.5 0.3 2.4 1 1 1 2 2 2 2 Dynamin family NB-ARC PF00931.22 EDO18807.1 - 0.0006 19.1 0.1 0.0012 18.1 0.1 1.4 1 0 0 1 1 1 1 NB-ARC domain ABC_tran PF00005.27 EDO18807.1 - 0.00073 20.1 0.4 0.0017 18.9 0.1 1.7 1 1 0 1 1 1 1 ABC transporter AAA_16 PF13191.6 EDO18807.1 - 0.00091 19.6 0.0 0.0018 18.7 0.0 1.7 1 1 0 1 1 1 1 AAA ATPase domain FtsK_SpoIIIE PF01580.18 EDO18807.1 - 0.0022 17.4 0.1 0.0037 16.7 0.1 1.3 1 0 0 1 1 1 1 FtsK/SpoIIIE family AAA_22 PF13401.6 EDO18807.1 - 0.0047 17.2 0.1 0.011 16.0 0.1 1.9 1 1 0 1 1 1 1 AAA domain AAA_24 PF13479.6 EDO18807.1 - 0.033 13.9 0.1 0.092 12.5 0.1 1.8 1 1 0 1 1 1 0 AAA domain AAA_29 PF13555.6 EDO18807.1 - 0.034 13.9 0.0 0.067 12.9 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Roc PF08477.13 EDO18807.1 - 0.044 14.0 0.0 0.097 12.9 0.0 1.6 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_33 PF13671.6 EDO18807.1 - 0.059 13.5 0.3 0.13 12.5 0.3 1.7 1 1 0 1 1 1 0 AAA domain IIGP PF05049.13 EDO18807.1 - 0.062 12.3 0.3 0.21 10.6 0.1 1.8 1 1 1 2 2 2 0 Interferon-inducible GTPase (IIGP) T2SSE PF00437.20 EDO18807.1 - 0.1 11.6 0.1 0.16 11.0 0.1 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein PduV-EutP PF10662.9 EDO18807.1 - 0.11 12.3 0.2 1.7 8.4 0.1 2.5 2 1 0 2 2 1 0 Ethanolamine utilisation - propanediol utilisation FeoB_N PF02421.18 EDO18807.1 - 0.11 12.0 0.2 0.3 10.6 0.2 1.7 1 1 0 1 1 1 0 Ferrous iron transport protein B FMN_red PF03358.15 EDO18808.1 - 9.6e-07 28.7 0.1 3.7e-06 26.8 0.0 1.8 2 0 0 2 2 2 1 NADPH-dependent FMN reductase Flavodoxin_1 PF00258.25 EDO18808.1 - 0.00059 20.1 0.5 0.0051 17.0 0.0 2.6 2 2 0 2 2 2 1 Flavodoxin Flavodoxin_5 PF12724.7 EDO18808.1 - 0.011 16.0 0.0 0.22 11.7 0.0 2.2 1 1 1 2 2 2 0 Flavodoxin domain ATP_synt_H PF05493.13 EDO18810.1 - 2.6e-20 72.6 6.0 3.2e-20 72.3 6.0 1.1 1 0 0 1 1 1 1 ATP synthase subunit H SCAMP PF04144.13 EDO18810.1 - 0.0085 16.4 2.5 0.0093 16.3 2.5 1.0 1 0 0 1 1 1 1 SCAMP family Git3 PF11710.8 EDO18810.1 - 0.01 15.6 1.0 0.011 15.5 1.0 1.1 1 0 0 1 1 1 0 G protein-coupled glucose receptor regulating Gpa2 DUF5592 PF17332.2 EDO18810.1 - 0.14 12.7 1.7 0.29 11.7 1.8 1.6 1 1 0 1 1 1 0 Family of unknown function (DUF5592) YfhO PF09586.10 EDO18810.1 - 0.16 10.2 2.3 0.16 10.1 2.3 1.0 1 0 0 1 1 1 0 Bacterial membrane protein YfhO DUF4131 PF13567.6 EDO18810.1 - 0.21 11.2 2.0 0.22 11.2 2.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) Lipase_3 PF01764.25 EDO18811.1 - 2.7e-37 127.8 0.0 4.5e-37 127.1 0.0 1.4 1 0 0 1 1 1 1 Lipase (class 3) DUF2974 PF11187.8 EDO18811.1 - 0.00094 18.8 0.0 0.39 10.2 0.0 2.5 3 0 0 3 3 3 2 Protein of unknown function (DUF2974) Esterase PF00756.20 EDO18811.1 - 0.0038 16.9 0.0 0.0063 16.2 0.0 1.3 1 0 0 1 1 1 1 Putative esterase Abhydrolase_5 PF12695.7 EDO18811.1 - 0.0057 16.4 0.0 0.013 15.3 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.7 EDO18811.1 - 0.011 16.4 0.0 0.016 15.8 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EDO18811.1 - 0.15 11.3 0.0 0.43 9.8 0.0 1.7 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Nnf1 PF03980.14 EDO18812.1 - 1.2e-27 96.4 5.5 2.1e-27 95.7 5.5 1.4 1 0 0 1 1 1 1 Nnf1 DUF1664 PF07889.12 EDO18812.1 - 0.016 15.3 2.9 0.03 14.4 0.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Prefoldin PF02996.17 EDO18812.1 - 0.04 13.8 5.5 0.072 13.0 1.8 2.6 2 1 0 2 2 2 0 Prefoldin subunit Spc29 PF17082.5 EDO18812.1 - 0.05 13.4 3.0 0.086 12.7 3.0 1.6 1 1 0 1 1 1 0 Spindle Pole Component 29 THOC7 PF05615.13 EDO18812.1 - 0.069 13.4 8.0 1.4 9.2 2.1 2.3 2 0 0 2 2 2 0 Tho complex subunit 7 DUF4298 PF14131.6 EDO18812.1 - 0.077 13.0 0.2 0.077 13.0 0.2 2.0 2 1 0 2 2 2 0 Domain of unknown function (DUF4298) Peptidase_C93 PF06035.11 EDO18812.1 - 0.11 12.3 2.2 0.22 11.3 0.1 2.3 2 1 0 2 2 2 0 Bacterial transglutaminase-like cysteine proteinase BTLCP Ta0938 PF11494.8 EDO18812.1 - 0.2 12.0 1.0 0.44 10.8 0.1 2.0 2 1 0 2 2 2 0 Ta0938 APP_E2 PF12925.7 EDO18812.1 - 0.61 9.8 4.7 0.29 10.8 0.7 2.0 2 0 0 2 2 2 0 E2 domain of amyloid precursor protein DUF4404 PF14357.6 EDO18812.1 - 0.7 10.6 7.0 0.081 13.6 2.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4404) YlqD PF11068.8 EDO18812.1 - 0.75 10.2 8.5 0.92 9.9 7.6 1.7 1 1 0 1 1 1 0 YlqD protein DUF16 PF01519.16 EDO18812.1 - 0.98 9.9 9.8 4.3 7.9 9.7 2.1 1 1 0 1 1 1 0 Protein of unknown function DUF16 LRRFIP PF09738.9 EDO18812.1 - 1.6 8.2 9.0 2.2 7.7 9.0 1.3 1 1 0 1 1 1 0 LRRFIP family Snapin_Pallidin PF14712.6 EDO18812.1 - 2.6 8.5 8.0 2.3 8.7 1.7 2.6 2 1 0 2 2 2 0 Snapin/Pallidin SlyX PF04102.12 EDO18812.1 - 3.4 8.3 11.4 1.9 9.2 4.0 3.1 2 1 1 3 3 3 0 SlyX bZIP_1 PF00170.21 EDO18812.1 - 4.7 7.4 10.2 0.51 10.5 5.4 1.8 2 0 0 2 2 2 0 bZIP transcription factor Cauli_AT PF03233.13 EDO18812.1 - 8.6 6.3 7.5 5.3 6.9 1.8 2.2 1 1 1 2 2 2 0 Aphid transmission protein EF-hand_4 PF12763.7 EDO18813.1 - 2e-23 82.3 2.8 1.1e-10 41.4 0.0 3.2 3 0 0 3 3 3 2 Cytoskeletal-regulatory complex EF hand UBA PF00627.31 EDO18813.1 - 1.5e-09 37.6 0.0 4e-09 36.2 0.0 1.8 1 0 0 1 1 1 1 UBA/TS-N domain EF-hand_1 PF00036.32 EDO18813.1 - 1.8e-05 23.9 1.7 0.0035 16.8 0.0 3.5 3 0 0 3 3 3 1 EF hand EF-hand_6 PF13405.6 EDO18813.1 - 2.1e-05 24.1 0.2 0.044 13.7 0.0 3.4 3 0 0 3 3 3 2 EF-hand domain UBA_4 PF14555.6 EDO18813.1 - 0.00011 21.9 0.3 0.00011 21.9 0.3 2.0 2 0 0 2 2 2 1 UBA-like domain EF-hand_7 PF13499.6 EDO18813.1 - 0.18 12.2 9.3 0.29 11.6 0.0 4.1 3 1 2 5 5 5 0 EF-hand domain pair MbeD_MobD PF04899.12 EDO18813.1 - 3.7 7.8 10.6 0.42 10.8 2.5 2.9 2 0 0 2 2 2 0 MbeD/MobD like Peptidase_M20 PF01546.28 EDO18815.1 - 1e-27 97.2 0.0 3e-27 95.7 0.0 1.8 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 EDO18815.1 - 6.4e-13 48.6 0.0 1.5e-12 47.4 0.0 1.6 1 1 0 1 1 1 1 Peptidase dimerisation domain Beta_elim_lyase PF01212.21 EDO18815.1 - 0.046 13.0 0.1 0.083 12.1 0.1 1.3 1 0 0 1 1 1 0 Beta-eliminating lyase Proteasome PF00227.26 EDO18816.1 - 1.3e-35 122.6 0.0 7.9e-35 120.1 0.0 1.9 1 1 0 1 1 1 1 Proteasome subunit Ribosomal_L13 PF00572.18 EDO18816.1 - 0.17 12.2 0.0 9.7 6.5 0.0 2.3 2 0 0 2 2 2 0 Ribosomal protein L13 ER_lumen_recept PF00810.18 EDO18817.1 - 9.8e-47 159.5 14.7 9.8e-47 159.5 14.7 1.5 2 0 0 2 2 2 1 ER lumen protein retaining receptor Sod_Cu PF00080.20 EDO18819.1 - 7.8e-45 152.5 4.3 9.3e-45 152.3 4.3 1.0 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) CTP_synth_N PF06418.14 EDO18820.1 - 4.9e-124 412.9 0.5 7e-124 412.4 0.5 1.2 1 0 0 1 1 1 1 CTP synthase N-terminus GATase PF00117.28 EDO18820.1 - 8.7e-58 195.2 0.0 1.4e-57 194.6 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 EDO18820.1 - 0.011 15.5 0.1 0.14 11.9 0.1 2.4 1 1 0 1 1 1 0 Peptidase C26 RVT_connect PF06815.13 EDO18820.1 - 0.29 11.4 1.9 1.5 9.1 0.2 2.3 2 0 0 2 2 2 0 Reverse transcriptase connection domain Tweety PF04906.13 EDO18821.1 - 0.067 11.8 1.6 0.11 11.2 1.6 1.3 1 0 0 1 1 1 0 Tweety DUF2274 PF10038.9 EDO18821.1 - 0.071 13.6 0.2 0.17 12.3 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2274) Nup54 PF13874.6 EDO18821.1 - 0.38 10.9 8.5 0.052 13.7 1.5 2.1 2 0 0 2 2 2 0 Nucleoporin complex subunit 54 MetOD2 PF18548.1 EDO18821.1 - 3.5 7.8 8.7 3.4 7.8 0.5 2.8 2 2 1 3 3 3 0 Metanogen output domain 2 PCRF PF03462.18 EDO18821.1 - 4.8 7.0 8.2 0.92 9.3 4.5 1.6 2 0 0 2 2 2 0 PCRF domain FliD_N PF02465.18 EDO18821.1 - 8.1 7.2 9.6 11 6.7 6.2 2.2 1 1 1 2 2 2 0 Flagellar hook-associated protein 2 N-terminus DUF3496 PF12001.8 EDO18821.1 - 8.6 6.8 17.0 4.4 7.7 9.0 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF3496) ESCRT-II PF05871.12 EDO18822.1 - 7.6e-44 149.4 1.1 9e-44 149.1 1.1 1.1 1 0 0 1 1 1 1 ESCRT-II complex subunit Sod_Fe_C PF02777.18 EDO18823.1 - 3.1e-15 56.2 1.1 1.3e-08 34.9 0.3 2.3 1 1 0 2 2 2 2 Iron/manganese superoxide dismutases, C-terminal domain Peptidase_C12 PF01088.21 EDO18824.1 - 4.7e-44 150.7 0.0 5.6e-44 150.4 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 PX PF00787.24 EDO18825.1 - 3.4e-08 33.4 1.4 6.1e-08 32.6 0.1 2.0 2 0 0 2 2 2 1 PX domain DUF2674 PF10879.8 EDO18825.1 - 0.13 11.8 0.1 0.64 9.6 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2674) Ribosomal_L37ae PF01780.19 EDO18826.1 - 2.6e-39 133.2 9.8 2.9e-39 133.0 9.8 1.0 1 0 0 1 1 1 1 Ribosomal L37ae protein family zf-RING_13 PF17977.1 EDO18826.1 - 0.00077 19.6 3.1 0.0011 19.1 3.1 1.2 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain CarbpepA_inh PF02977.15 EDO18826.1 - 0.0026 17.5 4.1 0.0045 16.8 1.1 2.1 1 1 1 2 2 2 1 Carboxypeptidase A inhibitor Rep_fac-A_C PF08646.10 EDO18826.1 - 0.015 15.0 0.2 0.018 14.8 0.2 1.2 1 0 0 1 1 1 0 Replication factor-A C terminal domain Zn_Tnp_IS1595 PF12760.7 EDO18826.1 - 0.02 14.8 3.6 0.036 14.1 3.6 1.4 1 0 0 1 1 1 0 Transposase zinc-ribbon domain C1_2 PF03107.16 EDO18826.1 - 0.03 14.7 1.9 4.3 7.7 0.1 2.1 1 1 1 2 2 2 0 C1 domain zf-H2C2_2 PF13465.6 EDO18826.1 - 0.036 14.5 0.6 1 9.9 0.1 2.3 2 0 0 2 2 2 0 Zinc-finger double domain Elf1 PF05129.13 EDO18826.1 - 0.05 13.6 1.3 0.1 12.7 1.3 1.6 1 1 0 1 1 1 0 Transcription elongation factor Elf1 like DUF2175 PF09943.9 EDO18826.1 - 0.071 13.4 0.4 3.3 8.1 0.0 2.3 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2175) zf-BED PF02892.15 EDO18826.1 - 0.11 12.5 4.0 2.4 8.3 0.2 2.2 1 1 1 2 2 2 0 BED zinc finger ZirS_C PF16583.5 EDO18826.1 - 0.16 11.5 0.0 0.2 11.3 0.0 1.2 1 0 0 1 1 1 0 Zinc-regulated secreted antivirulence protein C-terminal domain zf-C4_ClpX PF06689.13 EDO18826.1 - 3.4 7.6 5.4 11 6.0 5.5 2.0 1 1 0 1 1 1 0 ClpX C4-type zinc finger MBF1 PF08523.10 EDO18827.1 - 3.5e-23 81.9 2.0 3.5e-23 81.9 2.0 1.8 2 1 0 2 2 2 1 Multiprotein bridging factor 1 HTH_3 PF01381.22 EDO18827.1 - 3.7e-14 52.5 0.3 6.4e-14 51.7 0.3 1.3 1 0 0 1 1 1 1 Helix-turn-helix HTH_31 PF13560.6 EDO18827.1 - 0.00015 22.0 0.0 0.00029 21.1 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_19 PF12844.7 EDO18827.1 - 0.0016 18.4 0.1 0.0024 17.8 0.1 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain TRAP-gamma PF07074.12 EDO18827.1 - 0.37 10.3 0.7 0.5 9.9 0.7 1.2 1 0 0 1 1 1 0 Translocon-associated protein, gamma subunit (TRAP-gamma) Cauli_VI PF01693.16 EDO18828.1 - 3.3e-32 110.5 5.9 1.7e-18 66.6 2.5 2.7 2 0 0 2 2 2 2 Caulimovirus viroplasmin RNase_H PF00075.24 EDO18828.1 - 1.1e-29 103.5 1.4 2e-29 102.6 1.4 1.5 1 0 0 1 1 1 1 RNase H SWIB PF02201.18 EDO18829.1 - 3.9e-30 103.5 0.3 9.4e-30 102.3 0.3 1.7 1 0 0 1 1 1 1 SWIB/MDM2 domain DEK_C PF08766.11 EDO18829.1 - 5.5e-11 42.2 1.2 1.8e-09 37.4 0.1 3.3 3 0 0 3 3 3 1 DEK C terminal domain RRS1 PF04939.12 EDO18830.1 - 8e-60 201.4 1.1 9.3e-60 201.2 1.1 1.0 1 0 0 1 1 1 1 Ribosome biogenesis regulatory protein (RRS1) S10_plectin PF03501.15 EDO18831.1 - 1e-42 144.1 0.5 1.2e-42 143.9 0.5 1.0 1 0 0 1 1 1 1 Plectin/S10 domain tRNA-synt_1c_C PF03950.18 EDO18831.1 - 0.026 14.4 0.0 0.029 14.3 0.0 1.1 1 0 0 1 1 1 0 tRNA synthetases class I (E and Q), anti-codon binding domain MsyB PF13984.6 EDO18831.1 - 0.072 13.4 0.0 0.092 13.1 0.0 1.2 1 0 0 1 1 1 0 MsyB protein PadR PF03551.14 EDO18831.1 - 0.1 12.6 0.2 0.1 12.6 0.2 1.7 2 0 0 2 2 2 0 Transcriptional regulator PadR-like family ADH_N_2 PF16884.5 EDO18832.1 - 2.1e-20 72.6 0.0 3.4e-20 72.0 0.0 1.4 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase ADH_zinc_N PF00107.26 EDO18832.1 - 2.6e-15 56.6 0.0 3.9e-15 56.0 0.0 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EDO18832.1 - 0.033 15.2 0.0 0.073 14.1 0.0 1.6 1 0 0 1 1 1 0 Zinc-binding dehydrogenase CRC_subunit PF08624.10 EDO18833.1 - 4.3e-40 137.3 0.0 9.9e-40 136.1 0.0 1.6 1 0 0 1 1 1 1 Chromatin remodelling complex Rsc7/Swp82 subunit Lectin_leg-like PF03388.13 EDO18834.1 - 7.7e-49 166.1 0.0 1.1e-48 165.6 0.0 1.2 1 0 0 1 1 1 1 Legume-like lectin family Bact_lectin PF18483.1 EDO18834.1 - 0.04 13.9 0.1 0.37 10.8 0.0 2.5 1 1 1 2 2 2 0 Bacterial lectin PliI PF16743.5 EDO18834.1 - 0.059 13.1 0.0 0.1 12.3 0.0 1.3 1 0 0 1 1 1 0 Periplasmic lysozyme inhibitor of I-type lysozyme Tropomyosin_1 PF12718.7 EDO18834.1 - 0.62 10.2 6.0 1 9.5 6.0 1.4 1 0 0 1 1 1 0 Tropomyosin like DEP PF00610.21 EDO18836.1 - 1.3e-10 41.2 0.1 3.7e-10 39.7 0.1 1.8 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) RhoGAP PF00620.27 EDO18836.1 - 1.3e-09 38.1 5.9 1.7e-09 37.7 0.5 3.2 2 1 0 2 2 2 1 RhoGAP domain FCH PF00611.23 EDO18836.1 - 1.4e-08 34.9 0.0 3.6e-07 30.4 0.0 3.0 2 1 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain V-SNARE_C PF12352.8 EDO18838.1 - 1.8e-06 28.1 4.7 1.8e-06 28.1 4.7 1.8 2 0 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.13 EDO18838.1 - 2.6e-05 24.0 0.5 2.6e-05 24.0 0.5 2.1 3 0 0 3 3 3 1 Sec20 DUF4407 PF14362.6 EDO18838.1 - 7.1e-05 22.3 0.8 0.00013 21.5 0.8 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4407) Use1 PF09753.9 EDO18838.1 - 0.042 13.6 12.4 1.2 8.8 12.4 2.2 1 1 0 1 1 1 0 Membrane fusion protein Use1 MRP-L46 PF11788.8 EDO18838.1 - 0.047 14.4 2.0 0.81 10.4 1.4 2.5 2 1 0 2 2 2 0 39S mitochondrial ribosomal protein L46 DinB PF05163.12 EDO18838.1 - 0.052 13.5 0.3 0.12 12.3 0.3 1.6 1 0 0 1 1 1 0 DinB family CNDH2_M PF16869.5 EDO18838.1 - 0.13 13.0 2.5 0.25 12.0 2.5 1.4 1 0 0 1 1 1 0 PF16858 FapA PF03961.13 EDO18838.1 - 0.79 8.3 8.1 3.5 6.1 0.2 2.2 2 0 0 2 2 2 0 Flagellar Assembly Protein A DUF573 PF04504.14 EDO18838.1 - 0.94 10.2 7.2 1.2 9.9 3.6 2.6 2 1 0 2 2 2 0 Protein of unknown function, DUF573 LMBR1 PF04791.16 EDO18838.1 - 2 7.3 8.8 2.2 7.1 3.5 2.2 2 0 0 2 2 2 0 LMBR1-like membrane protein GrpE PF01025.19 EDO18838.1 - 4.3 7.0 9.9 1.4 8.6 1.9 2.8 2 1 1 3 3 3 0 GrpE DivIC PF04977.15 EDO18838.1 - 7 6.5 9.3 2.4 8.0 0.2 3.5 4 0 0 4 4 4 0 Septum formation initiator DUF4337 PF14235.6 EDO18838.1 - 9.1 6.4 13.3 0.37 10.9 2.6 3.0 2 2 1 3 3 3 0 Domain of unknown function (DUF4337) RCC1 PF00415.18 EDO18839.1 - 4.8e-21 75.1 0.8 1.7e-05 25.3 0.0 5.3 5 0 0 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EDO18839.1 - 3.1e-13 49.1 14.7 7.2e-09 35.2 0.3 5.2 6 0 0 6 6 6 3 Regulator of chromosome condensation (RCC1) repeat DUF1640 PF07798.11 EDO18840.1 - 2.2e-54 184.1 7.6 2.5e-54 183.9 7.6 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1640) FTA4 PF13093.6 EDO18840.1 - 0.0064 16.4 5.3 0.0077 16.1 5.3 1.1 1 0 0 1 1 1 1 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 DUF1732 PF08340.11 EDO18840.1 - 0.0089 16.0 5.4 0.0089 16.0 5.4 1.9 1 1 1 2 2 2 1 Domain of unknown function (DUF1732) T2SSM PF04612.12 EDO18840.1 - 0.012 15.6 0.2 0.028 14.5 0.0 1.7 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein M FliD_N PF02465.18 EDO18840.1 - 0.099 13.4 1.3 0.21 12.3 1.2 1.8 1 1 0 1 1 1 0 Flagellar hook-associated protein 2 N-terminus DUF501 PF04417.12 EDO18840.1 - 0.13 12.1 0.3 0.21 11.4 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF501) Uso1_p115_C PF04871.13 EDO18840.1 - 0.2 12.0 4.1 0.28 11.5 3.2 1.7 1 1 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region GreA_GreB_N PF03449.15 EDO18840.1 - 0.42 10.8 4.9 1.2 9.3 4.9 1.9 1 1 0 1 1 1 0 Transcription elongation factor, N-terminal HalX PF08663.10 EDO18840.1 - 0.51 10.7 5.2 0.27 11.6 1.9 2.2 1 1 2 3 3 3 0 HalX domain Fib_alpha PF08702.10 EDO18840.1 - 1.7 8.8 11.4 2 8.6 5.5 2.1 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Phage_lysis PF03245.13 EDO18840.1 - 3.7 7.7 9.8 1.5 9.0 1.4 2.3 1 1 1 2 2 2 0 Bacteriophage Rz lysis protein PMM PF03332.13 EDO18841.1 - 1.8e-112 374.5 0.5 2.1e-112 374.3 0.5 1.0 1 0 0 1 1 1 1 Eukaryotic phosphomannomutase Hydrolase_3 PF08282.12 EDO18841.1 - 5.8e-06 26.2 0.1 7.3e-05 22.6 0.0 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase TMPIT PF07851.13 EDO18841.1 - 0.036 13.3 0.1 0.05 12.9 0.1 1.2 1 0 0 1 1 1 0 TMPIT-like protein DUF600 PF04634.12 EDO18841.1 - 0.11 12.6 0.4 0.68 10.0 0.0 2.3 2 1 1 3 3 3 0 Protein of unknown function, DUF600 Hydrolase PF00702.26 EDO18841.1 - 0.13 12.6 0.0 0.21 11.8 0.0 1.6 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase Ribosomal_L16 PF00252.18 EDO18842.1 - 5.3e-42 143.0 0.1 6.5e-42 142.7 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e zf-C2H2_jaz PF12171.8 EDO18843.1 - 6.5e-10 39.0 5.4 6.5e-10 39.0 5.4 1.6 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 EDO18843.1 - 0.00059 20.1 0.5 0.00099 19.4 0.5 1.5 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) zf-C2HE PF16278.5 EDO18843.1 - 0.11 13.0 5.3 2.4 8.7 3.1 3.0 2 1 0 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_4 PF13894.6 EDO18843.1 - 0.3 12.1 2.3 0.59 11.1 1.2 2.1 2 0 0 2 2 2 0 C2H2-type zinc finger zf-met PF12874.7 EDO18843.1 - 2.5 8.6 7.0 3.1 8.3 4.7 2.3 3 0 0 3 3 3 0 Zinc-finger of C2H2 type OTU PF02338.19 EDO18844.1 - 1.3e-06 29.0 0.1 2.3e-06 28.1 0.1 1.4 1 0 0 1 1 1 1 OTU-like cysteine protease DUF5517 PF17639.2 EDO18844.1 - 0.13 12.5 0.6 0.4 11.0 0.4 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5517) zf-BED PF02892.15 EDO18844.1 - 0.17 11.9 0.3 0.44 10.6 0.3 1.7 1 0 0 1 1 1 0 BED zinc finger VASt PF16016.5 EDO18845.1 - 1.5e-37 129.4 0.7 3.1e-37 128.4 0.7 1.6 1 0 0 1 1 1 1 VAD1 Analog of StAR-related lipid transfer domain GRAM PF02893.20 EDO18845.1 - 3e-11 43.2 0.5 3e-11 43.2 0.5 2.0 2 0 0 2 2 2 1 GRAM domain CagY_I PF14585.6 EDO18845.1 - 0.028 14.5 0.9 0.19 11.8 0.1 2.6 2 0 0 2 2 2 0 CagY type 1 repeat GTP_EFTU PF00009.27 EDO18846.1 - 3.7e-62 209.3 0.4 9.5e-62 208.0 0.4 1.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 EDO18846.1 - 3.4e-37 126.9 0.0 8.1e-37 125.7 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_II PF14492.6 EDO18846.1 - 6.5e-31 106.3 0.0 1.4e-30 105.1 0.0 1.6 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.24 EDO18846.1 - 1.2e-24 86.2 0.0 3e-24 84.9 0.0 1.8 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 EDO18846.1 - 4e-13 49.5 2.1 7.2e-13 48.7 0.3 2.4 2 0 0 2 2 2 1 Elongation factor Tu domain 2 RF3_C PF16658.5 EDO18846.1 - 3e-06 27.1 0.0 8.5e-06 25.6 0.0 1.7 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain AvrPtoB_bdg PF16847.5 EDO18846.1 - 0.0037 17.7 0.0 0.44 11.1 0.0 2.6 2 0 0 2 2 2 1 Avirulence AvrPtoB, BAK1-binding domain MMR_HSR1 PF01926.23 EDO18846.1 - 0.0072 16.4 0.1 0.023 14.8 0.0 1.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase FAM167 PF11652.8 EDO18846.1 - 0.087 13.3 0.1 0.67 10.5 0.0 2.3 2 0 0 2 2 2 0 FAM167 SPC22 PF04573.12 EDO18847.1 - 5.9e-56 188.6 1.8 7.5e-56 188.3 1.8 1.1 1 0 0 1 1 1 1 Signal peptidase subunit Sugar_tr PF00083.24 EDO18848.1 - 1.2e-57 195.8 25.2 1.3e-57 195.6 25.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDO18848.1 - 3.9e-21 75.4 35.4 2.9e-19 69.2 25.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 EDO18848.1 - 0.0016 17.4 9.9 0.0058 15.5 5.7 2.5 2 0 0 2 2 2 2 MFS_1 like family Actin PF00022.19 EDO18849.1 - 8.1e-08 31.3 0.0 8.1e-08 31.3 0.0 1.0 1 0 0 1 1 1 1 Actin Actin PF00022.19 EDO18850.1 - 4.2e-106 355.0 0.0 1.4e-105 353.2 0.0 1.7 1 1 0 1 1 1 1 Actin GerD PF17898.1 EDO18850.1 - 0.18 11.7 0.8 0.28 11.1 0.1 1.6 2 0 0 2 2 2 0 Spore germination GerD central core domain TMEM208_SND2 PF05620.11 EDO18851.1 - 1.2e-49 168.3 0.3 1.4e-49 168.1 0.3 1.0 1 0 0 1 1 1 1 SRP-independent targeting protein 2/TMEM208 Ras PF00071.22 EDO18852.1 - 1.1e-64 217.0 0.5 1.3e-64 216.7 0.5 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EDO18852.1 - 4.6e-36 123.7 0.2 7.3e-36 123.0 0.2 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EDO18852.1 - 6.9e-17 61.5 0.2 9e-17 61.1 0.2 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EDO18852.1 - 2.8e-06 26.9 0.8 4.8e-06 26.1 0.8 1.4 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EDO18852.1 - 1.3e-05 24.9 0.2 3.6e-05 23.4 0.1 1.7 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EDO18852.1 - 0.00017 21.7 0.1 0.00032 20.8 0.1 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EDO18852.1 - 0.0022 17.9 0.9 0.11 12.4 0.1 2.2 1 1 1 2 2 2 1 RsgA GTPase SRPRB PF09439.10 EDO18852.1 - 0.0022 17.4 0.3 0.0035 16.8 0.1 1.5 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit AAA_7 PF12775.7 EDO18852.1 - 0.033 13.7 0.2 0.23 10.9 0.0 2.1 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_5 PF07728.14 EDO18852.1 - 0.054 13.5 0.0 0.085 12.9 0.0 1.6 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EDO18852.1 - 0.067 13.6 0.0 0.11 12.9 0.0 1.6 1 1 0 1 1 1 0 AAA ATPase domain FeoB_N PF02421.18 EDO18852.1 - 0.076 12.5 0.2 0.4 10.2 0.2 2.0 1 1 0 1 1 1 0 Ferrous iron transport protein B AAA_29 PF13555.6 EDO18852.1 - 0.088 12.6 0.0 0.22 11.3 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA PF00004.29 EDO18852.1 - 0.1 13.0 0.1 1.2 9.5 0.0 2.3 1 1 1 2 2 2 0 ATPase family associated with various cellular activities (AAA) ABC_tran PF00005.27 EDO18852.1 - 0.11 13.0 1.3 0.4 11.2 1.3 2.0 1 1 0 1 1 1 0 ABC transporter PLA2_B PF01735.18 EDO18854.1 - 1.3e-185 617.5 2.6 1.8e-185 617.1 2.6 1.2 1 0 0 1 1 1 1 Lysophospholipase catalytic domain EarP PF10093.9 EDO18854.1 - 0.089 11.9 0.1 0.16 11.0 0.1 1.3 1 0 0 1 1 1 0 Elongation-Factor P (EF-P) rhamnosyltransferase EarP Apt1 PF10351.9 EDO18854.1 - 5.1 5.8 7.3 8.1 5.2 7.3 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain DUF4674 PF15719.5 EDO18854.1 - 9.9 6.2 8.6 16 5.4 8.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4674) PX PF00787.24 EDO18855.1 - 1.1e-18 67.2 1.3 3.8e-18 65.5 0.1 2.4 3 0 0 3 3 3 1 PX domain Latarcin PF10279.9 EDO18855.1 - 0.048 14.1 0.1 0.048 14.1 0.1 2.9 3 1 0 3 3 3 0 Latarcin precursor MMM1 PF10296.9 EDO18856.1 - 4e-11 42.6 0.1 1.3e-10 40.8 0.1 1.9 1 1 0 1 1 1 1 Maintenance of mitochondrial morphology protein 1 Pkinase PF00069.25 EDO18857.1 - 1e-75 254.5 0.1 1.7e-75 253.8 0.1 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO18857.1 - 4.3e-42 144.2 0.0 7.8e-42 143.3 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase POLO_box PF00659.18 EDO18857.1 - 1.2e-23 83.0 0.3 6.9e-14 51.8 0.1 3.0 2 0 0 2 2 2 2 POLO box duplicated region Kinase-like PF14531.6 EDO18857.1 - 2.4e-09 36.9 0.0 3.8e-08 33.0 0.0 2.3 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 EDO18857.1 - 0.014 14.7 0.0 0.045 13.1 0.0 1.8 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Plk4_PB2 PF18409.1 EDO18857.1 - 0.24 12.1 4.5 9.6 6.9 0.1 3.8 4 1 0 4 4 4 0 Polo-like Kinase 4 Polo Box 2 Chitin_synth_1 PF01644.17 EDO18858.1 - 2.5e-69 232.4 0.7 2.5e-69 232.4 0.7 1.8 2 0 0 2 2 2 1 Chitin synthase Chitin_synth_1N PF08407.11 EDO18858.1 - 7.7e-26 89.8 0.1 2e-25 88.5 0.1 1.8 1 0 0 1 1 1 1 Chitin synthase N-terminal Chitin_synth_2 PF03142.15 EDO18858.1 - 3.6e-21 75.4 10.3 4.6e-15 55.2 0.0 2.8 3 0 0 3 3 3 2 Chitin synthase Glyco_trans_2_3 PF13632.6 EDO18858.1 - 2e-10 40.9 0.7 2e-10 40.9 0.7 2.4 3 1 0 3 3 3 1 Glycosyl transferase family group 2 Glycos_transf_2 PF00535.26 EDO18858.1 - 0.005 16.7 0.0 3.5 7.4 0.0 3.1 3 0 0 3 3 3 2 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 EDO18858.1 - 0.025 14.4 0.0 0.057 13.3 0.0 1.6 1 0 0 1 1 1 0 Glycosyltransferase like family 2 Nramp PF01566.18 EDO18859.1 - 1.3e-95 320.4 15.5 1.8e-95 320.0 15.5 1.1 1 0 0 1 1 1 1 Natural resistance-associated macrophage protein Bromodomain PF00439.25 EDO18860.1 - 1.2e-12 47.7 0.8 4.4e-12 45.9 0.8 2.0 1 0 0 1 1 1 1 Bromodomain SpoIIIAH PF12685.7 EDO18860.1 - 4 7.2 13.1 0.09 12.6 5.6 1.9 2 0 0 2 2 2 0 SpoIIIAH-like protein HA2 PF04408.23 EDO18861.1 - 1.9e-28 98.9 0.0 1.9e-28 98.9 0.0 3.3 4 0 0 4 4 4 1 Helicase associated domain (HA2) Helicase_C PF00271.31 EDO18861.1 - 2e-13 50.6 4.5 2.3e-11 44.0 0.0 4.0 4 0 0 4 4 4 1 Helicase conserved C-terminal domain OB_NTP_bind PF07717.16 EDO18861.1 - 4.2e-11 43.0 0.0 9.1e-11 42.0 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold DEAD PF00270.29 EDO18861.1 - 1e-08 35.1 0.0 3.2e-08 33.5 0.0 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 EDO18861.1 - 3e-06 27.6 0.2 1.3e-05 25.5 0.0 2.1 3 0 0 3 3 3 1 AAA domain AAA_19 PF13245.6 EDO18861.1 - 0.0017 18.7 0.0 0.0056 17.0 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EDO18861.1 - 0.0032 17.2 0.0 0.0078 15.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain ATPase PF06745.13 EDO18861.1 - 0.0059 16.0 1.6 0.018 14.4 0.0 2.6 3 0 0 3 3 3 1 KaiC HTH_37 PF13744.6 EDO18861.1 - 0.014 15.4 1.7 0.14 12.1 0.2 3.0 2 0 0 2 2 2 0 Helix-turn-helix domain PhoH PF02562.16 EDO18861.1 - 0.033 13.6 0.0 0.086 12.3 0.0 1.6 1 0 0 1 1 1 0 PhoH-like protein T2SSE PF00437.20 EDO18861.1 - 0.043 12.9 0.0 0.078 12.0 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein MOZ_SAS PF01853.18 EDO18862.1 - 7.7e-55 185.3 1.3 1.2e-54 184.7 0.6 1.5 2 0 0 2 2 2 1 MOZ/SAS family zf-MYST PF17772.1 EDO18862.1 - 1.2e-06 28.0 6.3 0.00058 19.4 3.3 2.5 2 0 0 2 2 2 2 MYST family zinc finger domain Acetyltransf_7 PF13508.7 EDO18862.1 - 0.036 14.5 0.0 0.075 13.5 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain SNF2_N PF00176.23 EDO18863.1 - 3.9e-62 210.0 0.0 6.1e-62 209.4 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain HIRAN PF08797.11 EDO18863.1 - 3.3e-16 59.0 0.0 7.5e-16 57.8 0.0 1.7 1 0 0 1 1 1 1 HIRAN domain Helicase_C PF00271.31 EDO18863.1 - 1.3e-14 54.5 0.1 5.9e-14 52.3 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain zf-RING_2 PF13639.6 EDO18863.1 - 1e-08 35.4 11.3 1.9e-08 34.5 11.3 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 EDO18863.1 - 7.5e-08 32.1 9.5 1.3e-07 31.4 9.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EDO18863.1 - 4.2e-06 26.5 13.3 9.1e-06 25.5 13.3 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EDO18863.1 - 6.7e-06 26.0 12.7 1.2e-05 25.1 12.7 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EDO18863.1 - 1.3e-05 25.1 9.6 2.7e-05 24.1 9.6 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-ANAPC11 PF12861.7 EDO18863.1 - 5.2e-05 23.2 4.2 9.9e-05 22.3 4.2 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.6 EDO18863.1 - 0.00074 19.3 11.7 0.0052 16.6 11.7 2.1 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 EDO18863.1 - 0.011 15.5 11.4 0.028 14.3 11.4 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EDO18863.1 - 0.053 13.8 8.0 0.12 12.7 8.0 1.6 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_4 PF14570.6 EDO18863.1 - 0.21 11.4 11.6 0.47 10.3 11.6 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-C3HC4_4 PF15227.6 EDO18863.1 - 0.71 10.1 11.8 1.9 8.7 11.8 1.8 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_11 PF17123.5 EDO18863.1 - 0.78 9.5 9.7 1.9 8.3 9.7 1.7 1 0 0 1 1 1 0 RING-like zinc finger Zn_ribbon_17 PF17120.5 EDO18863.1 - 1.9 8.2 6.0 3.7 7.2 6.0 1.5 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-C3HC4_5 PF17121.5 EDO18863.1 - 6 6.8 8.5 19 5.3 8.5 1.9 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) RNase_P_p30 PF01876.16 EDO18864.1 - 4e-75 252.0 0.1 4.8e-75 251.7 0.1 1.1 1 0 0 1 1 1 1 RNase P subunit p30 PMT PF02366.18 EDO18866.1 - 4.8e-15 55.8 23.8 1.3e-14 54.4 23.8 1.7 1 1 0 1 1 1 1 Dolichyl-phosphate-mannose-protein mannosyltransferase MIR PF02815.19 EDO18866.1 - 1.6e-13 50.9 1.8 5.5e-13 49.2 1.0 2.2 1 1 2 3 3 3 2 MIR domain Ins145_P3_rec PF08709.11 EDO18866.1 - 0.035 13.3 0.6 5.7 6.1 0.1 2.4 1 1 0 2 2 2 0 Inositol 1,4,5-trisphosphate/ryanodine receptor DUF5481 PF17578.2 EDO18866.1 - 0.039 14.3 0.0 0.25 11.8 0.0 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5481) LRR_5 PF13306.6 EDO18867.1 - 0.0046 16.9 0.8 0.22 11.5 0.0 3.1 2 2 0 2 2 2 1 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 EDO18867.1 - 0.99 9.9 4.4 32 5.1 0.2 4.8 5 2 0 5 5 5 0 Leucine Rich repeats (2 copies) IGR PF09597.10 EDO18868.1 - 2.4e-21 75.6 0.9 3.6e-21 75.0 0.9 1.3 1 0 0 1 1 1 1 IGR protein motif zf_C2H2_10 PF18414.1 EDO18868.1 - 0.16 11.5 0.0 0.24 10.9 0.0 1.2 1 0 0 1 1 1 0 C2H2 type zinc-finger Med6 PF04934.14 EDO18869.1 - 4.8e-51 172.0 15.5 2.6e-49 166.4 15.5 2.3 1 1 0 1 1 1 1 MED6 mediator sub complex component PIP5K PF01504.18 EDO18869.1 - 0.0033 16.7 2.7 0.0033 16.7 2.7 1.5 2 0 0 2 2 2 1 Phosphatidylinositol-4-phosphate 5-Kinase CoA_trans PF01144.23 EDO18869.1 - 0.084 12.3 0.0 0.13 11.7 0.0 1.2 1 0 0 1 1 1 0 Coenzyme A transferase Pex14_N PF04695.13 EDO18869.1 - 0.58 10.8 19.3 0.072 13.8 10.8 2.3 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Suf PF05843.14 EDO18869.1 - 0.95 9.4 16.1 0.45 10.5 9.6 2.1 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) DUF4512 PF14975.6 EDO18869.1 - 1.9 9.3 7.5 0.32 11.8 0.8 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4512) CobT PF06213.12 EDO18869.1 - 4.1 6.7 13.5 6.6 6.0 13.5 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Androgen_recep PF02166.16 EDO18869.1 - 4.1 6.1 25.2 7.1 5.4 25.2 1.3 1 0 0 1 1 1 0 Androgen receptor Pro_isomerase PF00160.21 EDO18870.1 - 3.3e-46 157.5 0.0 4e-46 157.2 0.0 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Pro_isomerase PF00160.21 EDO18871.1 - 1.9e-48 164.7 0.2 2.3e-48 164.5 0.2 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Zn_clus PF00172.18 EDO18872.1 - 5.2e-08 32.9 7.6 9e-08 32.1 7.6 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain AIM24 PF01987.17 EDO18873.1 - 6.6e-13 48.9 0.0 9.3e-13 48.4 0.0 1.5 1 1 0 1 1 1 1 Mitochondrial biogenesis AIM24 PIG-F PF06699.11 EDO18874.1 - 9.4e-25 87.8 19.3 1.9e-23 83.5 19.3 2.0 1 1 0 1 1 1 1 GPI biosynthesis protein family Pig-F TauE PF01925.19 EDO18874.1 - 0.13 11.8 10.3 1.7 8.2 10.1 2.1 1 1 0 1 1 1 0 Sulfite exporter TauE/SafE CPSF_A PF03178.15 EDO18875.1 - 2.6e-91 306.3 0.1 9.8e-91 304.4 0.1 2.1 1 0 0 1 1 1 1 CPSF A subunit region HPS3_N PF14761.6 EDO18875.1 - 0.00012 21.7 1.0 0.84 9.1 0.0 4.1 4 0 0 4 4 4 2 Hermansky-Pudlak syndrome 3 AA_kinase PF00696.28 EDO18876.1 - 1.1e-34 120.2 0.3 1.6e-34 119.6 0.3 1.3 1 0 0 1 1 1 1 Amino acid kinase family PUA PF01472.20 EDO18876.1 - 1.9e-20 72.6 0.2 4.9e-20 71.3 0.0 1.8 2 0 0 2 2 2 1 PUA domain OSCP PF00213.18 EDO18877.1 - 9.8e-12 45.3 0.1 1.1e-11 45.1 0.1 1.0 1 0 0 1 1 1 1 ATP synthase delta (OSCP) subunit Spo0A_C PF08769.11 EDO18877.1 - 0.04 14.0 0.0 0.061 13.4 0.0 1.4 1 1 0 1 1 1 0 Sporulation initiation factor Spo0A C terminal DUF1487 PF07368.11 EDO18877.1 - 0.047 13.1 0.0 0.047 13.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1487) FA_hydroxylase PF04116.13 EDO18878.1 - 1.7e-25 89.9 17.8 1e-24 87.4 10.9 2.1 2 0 0 2 2 2 2 Fatty acid hydroxylase superfamily Brr6_like_C_C PF10104.9 EDO18879.1 - 2e-42 144.1 5.5 3.8e-42 143.2 5.5 1.4 1 0 0 1 1 1 1 Di-sulfide bridge nucleocytoplasmic transport domain TMEM239 PF15841.5 EDO18879.1 - 0.057 13.3 0.3 0.12 12.3 0.0 1.6 2 0 0 2 2 2 0 Transmembrane protein 239 family Aldedh PF00171.22 EDO18880.1 - 2.7e-95 319.6 0.0 3.8e-95 319.1 0.0 1.1 1 0 0 1 1 1 1 Aldehyde dehydrogenase family RNB PF00773.19 EDO18881.1 - 1.3e-54 185.7 1.0 1.3e-54 185.7 1.0 2.0 3 0 0 3 3 3 1 RNB domain Dis3l2_C_term PF17877.1 EDO18881.1 - 3.1e-22 78.7 0.0 1.2e-21 76.8 0.0 2.2 1 0 0 1 1 1 1 DIS3-like exonuclease 2 C terminal OB_Dis3 PF17849.1 EDO18881.1 - 6.4e-22 77.4 0.2 2.3e-21 75.6 0.1 2.1 2 0 0 2 2 2 1 Dis3-like cold-shock domain 2 (CSD2) CSD2 PF17876.1 EDO18881.1 - 3.4e-07 30.3 0.0 0.00013 22.1 0.0 3.3 3 0 0 3 3 3 1 Cold shock domain Rrp44_CSD1 PF17216.3 EDO18881.1 - 0.00048 19.9 0.1 0.0019 18.0 0.1 2.0 1 0 0 1 1 1 1 Rrp44-like cold shock domain OB_RNB PF08206.11 EDO18881.1 - 0.00095 18.8 0.1 0.56 9.9 0.0 2.6 2 0 0 2 2 2 2 Ribonuclease B OB domain Tape_meas_lam_C PF09718.10 EDO18881.1 - 1.9 8.7 3.7 0.59 10.3 0.1 2.1 2 0 0 2 2 2 0 Lambda phage tail tape-measure protein (Tape_meas_lam_C) SseC PF04888.12 EDO18881.1 - 1.9 8.0 5.0 3.7 7.0 5.0 1.4 1 0 0 1 1 1 0 Secretion system effector C (SseC) like family Aldedh PF00171.22 EDO18882.1 - 4.7e-112 374.9 0.0 5.4e-112 374.6 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family V-ATPase_G PF03179.15 EDO18883.1 - 9.2e-30 103.3 8.3 1e-29 103.1 8.3 1.0 1 0 0 1 1 1 1 Vacuolar (H+)-ATPase G subunit ATP-synt_B PF00430.18 EDO18883.1 - 0.0039 17.3 10.5 0.014 15.5 10.5 1.7 1 1 0 1 1 1 1 ATP synthase B/B' CF(0) RE_AlwI PF09491.10 EDO18883.1 - 0.0094 14.8 0.6 0.01 14.7 0.6 1.2 1 0 0 1 1 1 1 AlwI restriction endonuclease V-ATPase_G_2 PF16999.5 EDO18883.1 - 0.011 16.2 6.6 0.016 15.6 6.6 1.3 1 0 0 1 1 1 0 Vacuolar (H+)-ATPase G subunit RR_TM4-6 PF06459.12 EDO18883.1 - 0.024 14.5 3.6 0.028 14.3 3.6 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF3552 PF12072.8 EDO18883.1 - 0.08 12.4 11.8 0.07 12.5 8.8 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF3552) HSCB_C PF07743.13 EDO18883.1 - 0.19 12.2 5.1 1.1 9.8 5.1 2.0 1 1 0 1 1 1 0 HSCB C-terminal oligomerisation domain zf-HIT PF04438.16 EDO18884.1 - 4e-08 33.0 13.6 7.9e-08 32.0 13.6 1.5 1 0 0 1 1 1 1 HIT zinc finger FAM110_C PF14160.6 EDO18884.1 - 5.2 8.2 9.7 23 6.1 0.3 2.7 2 0 0 2 2 2 0 Centrosome-associated C terminus SRX PF09201.10 EDO18885.1 - 3e-65 218.6 6.0 7.9e-65 217.2 6.0 1.8 1 0 0 1 1 1 1 SRX, signal recognition particle receptor alpha subunit SRP54 PF00448.22 EDO18885.1 - 5.1e-47 160.0 0.3 2.6e-44 151.2 0.3 2.5 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain SRP-alpha_N PF04086.13 EDO18885.1 - 2.9e-08 34.0 4.5 1.3e-07 31.8 4.4 2.0 2 0 0 2 2 2 1 Signal recognition particle, alpha subunit, N-terminal SRP54_N PF02881.19 EDO18885.1 - 1.5e-07 31.6 2.1 7.1e-07 29.4 0.3 2.9 2 1 1 3 3 3 1 SRP54-type protein, helical bundle domain MeaB PF03308.16 EDO18885.1 - 0.00031 19.8 0.0 0.00088 18.3 0.0 1.9 1 1 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB ArsA_ATPase PF02374.15 EDO18885.1 - 0.00046 19.5 2.3 0.095 11.9 0.0 3.4 3 0 0 3 3 3 1 Anion-transporting ATPase AAA_31 PF13614.6 EDO18885.1 - 0.00049 20.1 0.5 0.0086 16.0 0.5 2.8 1 1 0 1 1 1 1 AAA domain CbiA PF01656.23 EDO18885.1 - 0.0016 18.5 0.0 0.0056 16.7 0.0 2.0 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain Fer4_NifH PF00142.18 EDO18885.1 - 0.017 14.6 0.0 0.031 13.7 0.0 1.5 1 0 0 1 1 1 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family AAA_30 PF13604.6 EDO18885.1 - 0.039 13.7 0.0 0.081 12.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 EDO18885.1 - 0.1 12.7 0.2 0.85 9.8 0.0 2.6 3 0 0 3 3 3 0 AAA domain UBN_AB PF14075.6 EDO18885.1 - 7.4 6.2 9.7 0.95 9.1 2.8 2.6 2 2 0 2 2 2 0 Ubinuclein conserved middle domain DUF87 PF01935.17 EDO18885.1 - 9.9 6.2 10.4 1.2 9.2 0.3 3.5 4 0 0 4 4 4 0 Helicase HerA, central domain DEAD PF00270.29 EDO18886.1 - 1.9e-24 86.4 0.0 3.8e-24 85.4 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase DUF1998 PF09369.10 EDO18886.1 - 1.2e-20 74.0 0.1 3.8e-20 72.4 0.1 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF1998) Helicase_C PF00271.31 EDO18886.1 - 1e-14 54.8 0.7 1.3e-12 48.1 0.1 2.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDO18886.1 - 1.6e-09 38.0 0.1 3.3e-09 37.0 0.1 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CDT1 PF08839.11 EDO18886.1 - 7.5e-07 29.6 0.5 1.8e-06 28.4 0.5 1.6 1 0 0 1 1 1 1 DNA replication factor CDT1 like Terminase_GpA PF05876.12 EDO18886.1 - 0.14 10.7 0.0 0.24 9.9 0.0 1.3 1 0 0 1 1 1 0 Phage terminase large subunit (GpA) Acetyltransf_1 PF00583.25 EDO18888.1 - 4.8e-14 52.6 0.0 6.8e-14 52.1 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EDO18888.1 - 5.7e-08 32.8 0.0 7.8e-08 32.3 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EDO18888.1 - 6.6e-06 26.0 0.0 1.1e-05 25.3 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_7 PF13508.7 EDO18888.1 - 0.00014 22.2 0.0 0.00024 21.5 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_15 PF17013.5 EDO18888.1 - 0.001 18.6 1.0 0.0033 16.9 0.1 1.8 1 1 0 2 2 2 1 Putative acetyl-transferase Acetyltransf_9 PF13527.7 EDO18888.1 - 0.0061 16.6 0.0 0.01 15.9 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Cytokin_check_N PF10407.9 EDO18888.1 - 0.019 14.9 1.3 1.5 8.8 0.0 3.2 3 0 0 3 3 3 0 Cdc14 phosphatase binding protein N-terminus Acetyltransf_CG PF14542.6 EDO18888.1 - 0.064 13.4 0.0 0.2 11.8 0.0 1.8 1 1 0 1 1 1 0 GCN5-related N-acetyl-transferase Metallophos_2 PF12850.7 EDO18889.1 - 5.8e-09 36.4 0.0 9.7e-09 35.6 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Coilin_N PF15862.5 EDO18889.1 - 0.00022 21.1 3.5 0.00031 20.6 3.5 1.4 1 0 0 1 1 1 1 Coilin N-terminus GAGA_bind PF06217.12 EDO18889.1 - 0.00045 20.6 3.2 0.00054 20.3 3.2 1.1 1 0 0 1 1 1 1 GAGA binding protein-like family NST1 PF13945.6 EDO18889.1 - 0.076 13.1 20.0 0.11 12.6 20.0 1.2 1 0 0 1 1 1 0 Salt tolerance down-regulator Neur_chan_memb PF02932.16 EDO18889.1 - 0.14 12.2 0.6 0.16 12.0 0.6 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region FAM60A PF15396.6 EDO18889.1 - 0.37 10.8 9.2 0.5 10.3 9.2 1.2 1 0 0 1 1 1 0 Protein Family FAM60A SLC12 PF03522.15 EDO18889.1 - 0.42 9.6 10.3 0.58 9.1 10.3 1.2 1 0 0 1 1 1 0 Solute carrier family 12 DDHD PF02862.17 EDO18889.1 - 0.69 10.0 5.8 0.94 9.6 5.8 1.2 1 0 0 1 1 1 0 DDHD domain Peptidase_U57 PF05582.12 EDO18889.1 - 0.69 9.1 6.9 1 8.5 6.9 1.2 1 0 0 1 1 1 0 YabG peptidase U57 Membralin PF09746.9 EDO18889.1 - 1.2 8.1 6.8 1.6 7.7 6.8 1.1 1 0 0 1 1 1 0 Tumour-associated protein Presenilin PF01080.17 EDO18889.1 - 1.7 7.3 13.8 2.1 7.0 13.8 1.1 1 0 0 1 1 1 0 Presenilin CPSF100_C PF13299.6 EDO18889.1 - 3.4 7.8 12.7 5.9 7.0 12.7 1.4 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal XRN_M PF17846.1 EDO18889.1 - 5.6 5.8 11.6 7.7 5.4 11.6 1.2 1 0 0 1 1 1 0 Xrn1 helical domain SAPS PF04499.15 EDO18889.1 - 6.1 5.5 17.2 8 5.1 17.2 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Vfa1 PF08432.10 EDO18889.1 - 6.3 7.1 21.6 10 6.4 21.6 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Rtf2 PF04641.12 EDO18889.1 - 6.9 5.9 20.6 9.7 5.5 20.6 1.2 1 0 0 1 1 1 0 Rtf2 RING-finger DUF3807 PF12720.7 EDO18889.1 - 8 6.7 20.4 11 6.2 20.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) RNA_polI_A34 PF08208.11 EDO18889.1 - 8.3 6.4 23.8 14 5.7 23.8 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 tRNA-synt_2b PF00587.25 EDO18890.1 - 1.8e-23 83.4 0.0 3.1e-23 82.7 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.22 EDO18890.1 - 6.4e-05 23.1 2.8 0.00012 22.3 2.8 1.5 1 0 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain LOH1CR12 PF10158.9 EDO18890.1 - 0.036 14.1 0.6 0.11 12.6 0.6 1.8 1 1 0 1 1 1 0 Tumour suppressor protein DUF1978 PF09321.10 EDO18890.1 - 0.054 12.8 0.7 0.11 11.8 0.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1978) Med10 PF09748.9 EDO18890.1 - 0.18 11.8 3.5 4.1 7.4 0.0 3.1 2 1 0 2 2 2 0 Transcription factor subunit Med10 of Mediator complex DAO PF01266.24 EDO18891.1 - 1.7e-68 231.8 0.0 2e-68 231.6 0.0 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EDO18891.1 - 5e-06 26.7 0.1 1.3e-05 25.3 0.1 1.7 1 1 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EDO18891.1 - 0.00037 19.8 0.0 0.12 11.6 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 EDO18891.1 - 0.00039 19.4 0.1 0.079 11.8 0.3 2.1 2 0 0 2 2 2 2 Tryptophan halogenase MCRA PF06100.11 EDO18891.1 - 0.00056 18.8 0.0 0.00094 18.1 0.0 1.3 1 0 0 1 1 1 1 MCRA family CENP-B_dimeris PF09026.10 EDO18891.1 - 0.0084 16.5 3.1 0.017 15.5 3.1 1.4 1 0 0 1 1 1 1 Centromere protein B dimerisation domain NAD_binding_9 PF13454.6 EDO18891.1 - 0.013 15.5 0.1 0.026 14.5 0.1 1.4 1 0 0 1 1 1 0 FAD-NAD(P)-binding Thi4 PF01946.17 EDO18891.1 - 0.025 13.8 0.4 0.046 13.0 0.4 1.4 1 0 0 1 1 1 0 Thi4 family Cwf_Cwc_15 PF04889.12 EDO18891.1 - 0.067 12.9 8.4 0.11 12.2 8.4 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DUF3246 PF11596.8 EDO18891.1 - 1.3 8.4 5.4 3.2 7.1 5.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3246) PBP1_TM PF14812.6 EDO18891.1 - 1.7 9.0 10.4 3.3 8.2 10.4 1.4 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal NOA36 PF06524.12 EDO18891.1 - 5.3 6.3 11.6 7.9 5.7 11.6 1.1 1 0 0 1 1 1 0 NOA36 protein p450 PF00067.22 EDO18892.1 - 2.2e-91 306.9 0.1 2.5e-91 306.7 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF3641 PF12345.8 EDO18892.1 - 0.019 15.0 0.2 0.21 11.6 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3641) DUF3020 PF11223.8 EDO18893.1 - 8.3e-25 87.1 35.4 2.6e-17 63.1 11.3 8.2 8 1 0 8 8 8 2 Protein of unknown function (DUF3020) DUF3755 PF12579.8 EDO18893.1 - 3.7 7.3 6.8 17 5.2 1.1 3.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3755) DUF1284 PF06935.11 EDO18893.1 - 3.7 8.0 5.5 1.6 9.2 0.9 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1284) zf-C2H2 PF00096.26 EDO18894.1 - 0.00012 22.3 12.5 0.0003 21.1 2.6 3.7 3 0 0 3 3 3 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EDO18894.1 - 0.0025 18.5 10.9 0.019 15.8 1.2 3.8 3 0 0 3 3 3 1 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EDO18894.1 - 0.0026 18.1 1.4 0.0026 18.1 1.4 3.6 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2HE PF16278.5 EDO18894.1 - 0.031 14.7 4.7 4.2 7.9 0.0 3.8 3 0 0 3 3 3 0 C2HE / C2H2 / C2HC zinc-binding finger PyrI_C PF02748.15 EDO18894.1 - 0.061 13.2 0.6 0.17 11.8 0.0 2.1 2 0 0 2 2 2 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain PriA_CRR PF18319.1 EDO18894.1 - 0.31 11.1 0.1 0.31 11.1 0.1 2.3 3 0 0 3 3 3 0 PriA DNA helicase Cys-rich region (CRR) domain Rep_fac-A_C PF08646.10 EDO18894.1 - 0.53 10.0 2.7 0.36 10.6 0.2 1.9 2 0 0 2 2 2 0 Replication factor-A C terminal domain C1_1 PF00130.22 EDO18894.1 - 4 7.4 6.4 1.1 9.1 0.7 2.4 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) TPT PF03151.16 EDO18895.1 - 4.7e-14 52.4 18.1 5.2e-08 32.6 7.1 2.3 1 1 0 2 2 2 2 Triose-phosphate Transporter family UAA PF08449.11 EDO18895.1 - 1.2e-10 41.2 3.5 1.2e-10 41.2 3.5 2.2 2 0 0 2 2 2 1 UAA transporter family EamA PF00892.20 EDO18895.1 - 3.2e-05 24.1 30.7 0.00032 20.9 6.8 4.1 4 1 0 4 4 4 2 EamA-like transporter family DUF1201 PF06716.11 EDO18895.1 - 0.019 15.0 1.2 0.056 13.5 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1201) MRP-L28 PF09812.9 EDO18896.1 - 4.7e-35 121.1 1.5 5.7e-35 120.8 1.5 1.0 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L28 Nkap_C PF06047.11 EDO18896.1 - 0.1 12.7 0.4 0.18 11.9 0.4 1.4 1 1 0 1 1 1 0 NF-kappa-B-activating protein C-terminal domain CGI-121 PF08617.10 EDO18897.1 - 1.7e-37 129.0 0.2 2.1e-37 128.7 0.2 1.0 1 0 0 1 1 1 1 Kinase binding protein CGI-121 MAT1 PF06391.13 EDO18898.1 - 1.3e-65 221.1 21.3 1.7e-65 220.7 21.3 1.1 1 0 0 1 1 1 1 CDK-activating kinase assembly factor MAT1 zf-C3HC4_5 PF17121.5 EDO18898.1 - 1.5e-26 92.0 8.2 3e-26 91.1 8.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EDO18898.1 - 0.00029 20.6 4.5 0.00058 19.7 4.5 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EDO18898.1 - 0.0015 18.8 6.8 0.0027 18.0 6.8 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 EDO18898.1 - 0.0015 18.3 2.8 0.0045 16.8 2.8 1.8 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EDO18898.1 - 0.0064 16.3 6.1 0.011 15.5 6.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) FliS PF02561.14 EDO18898.1 - 0.0082 16.4 1.6 0.0082 16.4 1.6 2.2 1 1 1 2 2 2 1 Flagellar protein FliS zf-RING_UBOX PF13445.6 EDO18898.1 - 0.041 13.9 6.6 0.084 12.9 6.6 1.5 1 0 0 1 1 1 0 RING-type zinc-finger Spectrin PF00435.21 EDO18898.1 - 0.053 14.0 9.4 0.079 13.5 7.9 2.1 1 1 0 1 1 1 0 Spectrin repeat zf-RING_5 PF14634.6 EDO18898.1 - 0.079 12.9 7.1 0.21 11.6 7.1 1.7 1 1 0 1 1 1 0 zinc-RING finger domain 3HCDH_N PF02737.18 EDO18898.1 - 0.14 12.0 2.9 0.24 11.2 2.9 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain zf-RING_4 PF14570.6 EDO18898.1 - 0.59 10.0 7.2 1.6 8.6 7.2 1.7 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain UPF0122 PF04297.14 EDO18898.1 - 1.8 8.8 12.1 0.77 10.0 6.8 2.7 1 1 2 3 3 3 0 Putative helix-turn-helix protein, YlxM / p13 like A_deaminase PF00962.22 EDO18899.1 - 2.1e-130 434.8 0.1 3.7e-130 434.0 0.1 1.4 1 0 0 1 1 1 1 Adenosine/AMP deaminase MSC PF09402.10 EDO18900.1 - 6.1e-84 282.3 2.7 6.1e-84 282.3 2.7 1.9 2 0 0 2 2 2 1 Man1-Src1p-C-terminal domain HeH PF12949.7 EDO18900.1 - 3.6e-14 52.2 0.3 1.3e-13 50.4 0.3 2.1 1 0 0 1 1 1 1 HeH/LEM domain Raptor_N PF14538.6 EDO18900.1 - 0.0088 16.0 0.1 0.05 13.6 0.0 2.3 2 0 0 2 2 2 1 Raptor N-terminal CASPase like domain Sec62 PF03839.16 EDO18900.1 - 7.8 5.9 13.3 2.8e+02 0.9 13.3 2.5 1 1 0 1 1 1 0 Translocation protein Sec62 HECT PF00632.25 EDO18901.1 - 4.7e-90 302.2 0.2 4.7e-90 302.2 0.2 3.0 4 0 0 4 4 4 1 HECT-domain (ubiquitin-transferase) DUF908 PF06012.12 EDO18901.1 - 6.6e-60 203.4 9.2 8e-60 203.1 5.9 2.8 2 1 0 2 2 2 1 Domain of Unknown Function (DUF908) DUF913 PF06025.12 EDO18901.1 - 1.6e-53 182.0 0.0 1.6e-53 182.0 0.0 3.3 4 0 0 4 4 4 1 Domain of Unknown Function (DUF913) UBM PF14377.6 EDO18901.1 - 1.2e-15 56.3 9.9 4.6e-10 38.6 0.5 3.2 3 0 0 3 3 3 2 Ubiquitin binding region Rad52_Rad22 PF04098.15 EDO18902.1 - 3.3e-56 189.5 0.0 6.1e-56 188.6 0.0 1.4 1 0 0 1 1 1 1 Rad52/22 family double-strand break repair protein Ndc1_Nup PF09531.10 EDO18903.1 - 4.9e-103 345.9 11.6 7.3e-103 345.3 11.6 1.3 1 0 0 1 1 1 1 Nucleoporin protein Ndc1-Nup Na_H_Exchanger PF00999.21 EDO18904.1 - 4.9e-71 239.5 34.6 6.1e-71 239.2 34.6 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family Holin_2-3 PF13272.6 EDO18904.1 - 0.048 14.0 0.0 0.16 12.3 0.0 1.8 1 0 0 1 1 1 0 Putative 2/3 transmembrane domain holin Guanylate_kin PF00625.21 EDO18905.1 - 3.8e-65 219.0 0.0 4.2e-65 218.9 0.0 1.0 1 0 0 1 1 1 1 Guanylate kinase AAA_16 PF13191.6 EDO18905.1 - 5.6e-06 26.9 0.6 5.6e-05 23.6 0.6 2.2 1 1 0 1 1 1 1 AAA ATPase domain MMR_HSR1 PF01926.23 EDO18905.1 - 5.7e-06 26.4 0.1 4.5e-05 23.5 0.1 2.1 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_33 PF13671.6 EDO18905.1 - 4.3e-05 23.7 0.0 0.00018 21.7 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EDO18905.1 - 5.6e-05 23.4 0.0 0.00034 20.9 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.6 EDO18905.1 - 0.00019 21.2 0.2 0.0029 17.4 0.2 2.1 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EDO18905.1 - 0.00032 21.3 0.0 0.00068 20.2 0.0 1.8 1 1 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 EDO18905.1 - 0.00069 20.0 0.0 0.0017 18.7 0.0 1.7 1 1 0 1 1 1 1 RNA helicase AAA_29 PF13555.6 EDO18905.1 - 0.001 18.8 0.3 0.022 14.5 0.1 2.4 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_28 PF13521.6 EDO18905.1 - 0.0012 19.1 0.1 0.0023 18.2 0.1 1.4 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 EDO18905.1 - 0.0013 19.1 0.3 0.0094 16.4 0.3 2.2 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ABC_tran PF00005.27 EDO18905.1 - 0.0018 18.8 0.0 0.0033 17.9 0.0 1.5 1 0 0 1 1 1 1 ABC transporter Rad17 PF03215.15 EDO18905.1 - 0.0018 18.2 0.0 0.0042 17.0 0.0 1.5 1 1 0 1 1 1 1 Rad17 P-loop domain AAA_14 PF13173.6 EDO18905.1 - 0.0028 17.7 0.0 0.0091 16.0 0.0 2.0 2 2 0 2 2 2 1 AAA domain NACHT PF05729.12 EDO18905.1 - 0.0029 17.5 0.0 0.013 15.4 0.0 1.9 2 0 0 2 2 2 1 NACHT domain RsgA_GTPase PF03193.16 EDO18905.1 - 0.0041 17.1 0.0 0.0076 16.2 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_30 PF13604.6 EDO18905.1 - 0.011 15.4 0.0 0.028 14.2 0.0 1.6 2 0 0 2 2 2 0 AAA domain T2SSE PF00437.20 EDO18905.1 - 0.012 14.7 0.1 0.034 13.2 0.0 1.7 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_7 PF12775.7 EDO18905.1 - 0.019 14.5 0.0 0.042 13.4 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region DUF2075 PF09848.9 EDO18905.1 - 0.023 13.9 0.0 0.11 11.7 0.0 1.9 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) NTPase_1 PF03266.15 EDO18905.1 - 0.027 14.4 0.1 0.05 13.5 0.0 1.5 2 0 0 2 2 1 0 NTPase AAA_19 PF13245.6 EDO18905.1 - 0.044 14.1 0.0 0.84 10.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.14 EDO18905.1 - 0.069 13.1 0.0 0.5 10.4 0.0 2.1 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) ATPase_2 PF01637.18 EDO18905.1 - 0.074 12.9 0.0 0.2 11.5 0.0 1.7 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea AAA_2 PF07724.14 EDO18905.1 - 0.082 13.0 0.0 0.86 9.7 0.0 2.0 2 0 0 2 2 2 0 AAA domain (Cdc48 subfamily) cobW PF02492.19 EDO18905.1 - 0.083 12.5 0.1 0.21 11.2 0.0 1.6 2 0 0 2 2 1 0 CobW/HypB/UreG, nucleotide-binding domain Viral_helicase1 PF01443.18 EDO18905.1 - 0.084 12.6 0.1 0.29 10.8 0.1 1.8 1 1 1 2 2 2 0 Viral (Superfamily 1) RNA helicase Adeno_IVa2 PF02456.15 EDO18905.1 - 0.085 11.6 0.0 0.13 11.0 0.0 1.2 1 0 0 1 1 1 0 Adenovirus IVa2 protein KAP_NTPase PF07693.14 EDO18905.1 - 0.11 11.6 0.0 0.17 11.1 0.0 1.4 1 1 0 1 1 1 0 KAP family P-loop domain Cytidylate_kin PF02224.18 EDO18905.1 - 0.12 12.1 0.0 0.2 11.3 0.0 1.4 1 0 0 1 1 1 0 Cytidylate kinase AAA_23 PF13476.6 EDO18905.1 - 0.15 12.5 1.2 0.23 11.9 0.5 1.7 1 1 0 2 2 1 0 AAA domain dNK PF01712.19 EDO18905.1 - 0.15 11.9 0.2 0.59 9.9 0.0 2.0 2 1 0 2 2 2 0 Deoxynucleoside kinase HIG_1_N PF04588.13 EDO18906.1 - 7.8e-17 61.2 1.4 1.2e-16 60.7 1.4 1.3 1 0 0 1 1 1 1 Hypoxia induced protein conserved region DUF2570 PF10828.8 EDO18906.1 - 0.002 17.9 5.5 0.002 17.9 5.5 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF2570) Ureide_permease PF07168.11 EDO18906.1 - 0.0021 16.9 0.9 0.0027 16.5 0.9 1.1 1 0 0 1 1 1 1 Ureide permease Hormone_1 PF00103.20 EDO18906.1 - 0.12 12.1 5.6 0.17 11.6 5.6 1.2 1 0 0 1 1 1 0 Somatotropin hormone family ATP19 PF11022.8 EDO18906.1 - 0.16 12.4 1.0 3 8.3 1.0 2.4 1 1 0 1 1 1 0 ATP synthase subunit K AAA_23 PF13476.6 EDO18906.1 - 0.45 11.0 8.6 0.52 10.8 8.6 1.2 1 0 0 1 1 1 0 AAA domain ubiquitin PF00240.23 EDO18907.1 - 0.00019 21.1 0.1 0.00078 19.2 0.1 2.1 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 EDO18907.1 - 0.022 14.6 0.2 2.7 7.9 0.1 3.1 2 0 0 2 2 2 0 Ubiquitin-2 like Rad60 SUMO-like Amastin PF07344.11 EDO18907.1 - 0.046 13.6 0.2 0.081 12.8 0.2 1.3 1 0 0 1 1 1 0 Amastin surface glycoprotein PRP38 PF03371.15 EDO18907.1 - 0.079 12.8 0.4 0.22 11.4 0.1 2.0 2 0 0 2 2 2 0 PRP38 family AhpC-TSA PF00578.21 EDO18908.1 - 4e-32 110.7 0.0 6.5e-32 110.1 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 EDO18908.1 - 1.2e-17 64.0 0.1 2.3e-17 63.1 0.0 1.4 2 0 0 2 2 2 1 Redoxin 1-cysPrx_C PF10417.9 EDO18908.1 - 4.7e-10 39.1 0.1 9.4e-10 38.2 0.1 1.5 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin SCO1-SenC PF02630.14 EDO18908.1 - 0.094 12.6 0.1 0.23 11.4 0.1 1.6 2 0 0 2 2 2 0 SCO1/SenC Homeodomain PF00046.29 EDO18909.1 - 6e-14 51.6 1.6 1.5e-13 50.4 1.6 1.7 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EDO18909.1 - 0.032 14.1 1.8 0.27 11.1 1.8 2.4 1 1 0 1 1 1 0 Homeobox KN domain Ribosomal_S13 PF00416.22 EDO18910.1 - 3e-57 192.5 1.9 3.4e-57 192.3 1.9 1.0 1 0 0 1 1 1 1 Ribosomal protein S13/S18 FbpA PF05833.11 EDO18910.1 - 0.0047 15.7 0.0 0.0054 15.5 0.0 1.2 1 0 0 1 1 1 1 Fibronectin-binding protein A N-terminus (FbpA) DUF2746 PF10874.8 EDO18910.1 - 0.092 13.2 0.0 0.16 12.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2746) HHH_6 PF14579.6 EDO18910.1 - 0.11 12.8 0.1 0.62 10.3 0.1 2.2 1 1 1 2 2 2 0 Helix-hairpin-helix motif U3_assoc_6 PF08640.11 EDO18911.1 - 3.5e-32 110.3 4.5 3.2e-30 104.0 1.1 3.0 2 1 0 2 2 2 2 U3 small nucleolar RNA-associated protein 6 NRDE-2 PF08424.10 EDO18911.1 - 0.00029 20.1 4.1 0.0078 15.4 0.9 2.5 1 1 1 2 2 2 2 NRDE-2, necessary for RNA interference Suf PF05843.14 EDO18911.1 - 0.001 19.2 6.3 0.018 15.0 3.1 3.4 2 1 0 2 2 2 1 Suppressor of forked protein (Suf) TPR_14 PF13428.6 EDO18911.1 - 0.0025 18.5 0.0 1.6 9.8 0.0 3.2 1 1 2 3 3 3 1 Tetratricopeptide repeat ZZ PF00569.17 EDO18912.1 - 6.6e-16 57.8 7.8 1.1e-15 57.1 7.8 1.4 1 0 0 1 1 1 1 Zinc finger, ZZ type SWIRM PF04433.17 EDO18912.1 - 4e-10 39.9 0.2 6.4e-09 36.0 0.0 2.5 2 0 0 2 2 2 1 SWIRM domain Myb_DNA-binding PF00249.31 EDO18912.1 - 6.5e-08 32.6 0.0 1.9e-07 31.1 0.0 1.9 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EDO18912.1 - 0.0045 17.2 0.0 0.012 15.8 0.0 1.8 1 0 0 1 1 1 1 Myb-like DNA-binding domain Ribosomal_S17e PF00833.18 EDO18913.1 - 7.3e-57 190.6 0.3 8.6e-57 190.3 0.3 1.1 1 0 0 1 1 1 1 Ribosomal S17 Nse5 PF08691.10 EDO18914.1 - 1.1e-177 591.8 36.9 1.4e-177 591.5 36.9 1.0 1 0 0 1 1 1 1 DNA repair proteins Nse5 and Nse6 LAP1C PF05609.12 EDO18914.1 - 0.056 12.5 0.0 0.087 11.9 0.0 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Metallophos PF00149.28 EDO18915.1 - 6.2e-36 124.8 0.7 1.1e-35 123.9 0.1 1.8 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 EDO18915.1 - 4.7e-18 65.4 0.2 1e-17 64.2 0.2 1.7 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain POPLD PF08170.12 EDO18915.1 - 0.9 9.9 2.7 7.7 6.9 0.1 2.7 1 1 1 2 2 2 0 POPLD (NUC188) domain LCM PF04072.14 EDO18916.1 - 1e-23 84.3 0.0 1.5e-23 83.8 0.0 1.3 1 0 0 1 1 1 1 Leucine carboxyl methyltransferase PIG-S PF10510.9 EDO18917.1 - 2.7e-119 399.3 6.5 3.4e-119 399.0 6.5 1.0 1 0 0 1 1 1 1 Phosphatidylinositol-glycan biosynthesis class S protein Methyltransf_11 PF08241.12 EDO18918.1 - 5e-12 46.3 0.0 1.1e-11 45.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDO18918.1 - 1.4e-09 38.6 0.0 3.1e-09 37.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDO18918.1 - 2.6e-05 24.1 0.2 5.3e-05 23.0 0.2 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EDO18918.1 - 6.3e-05 23.6 0.2 0.00043 21.0 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 EDO18918.1 - 8.2e-05 22.5 0.0 0.00019 21.3 0.0 1.5 1 1 1 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.18 EDO18918.1 - 0.0055 16.1 0.0 0.024 14.0 0.0 1.9 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family HA1 PF18239.1 EDO18918.1 - 0.011 15.6 0.0 0.022 14.6 0.0 1.5 1 0 0 1 1 1 0 Hemagglutinin I PDDEXK_1 PF12705.7 EDO18918.1 - 0.022 14.7 1.3 0.046 13.6 1.0 1.6 1 1 0 1 1 1 0 PD-(D/E)XK nuclease superfamily RRM_1 PF00076.22 EDO18919.1 - 2.5e-29 100.9 0.5 1e-17 63.7 0.2 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EDO18919.1 - 0.0022 17.8 0.0 0.0058 16.5 0.0 1.6 2 0 0 2 2 2 1 Occluded RNA-recognition motif RRM_5 PF13893.6 EDO18919.1 - 0.01 15.4 0.0 0.018 14.6 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EDO18919.1 - 0.078 13.1 0.0 0.81 9.8 0.0 2.2 1 1 0 1 1 1 0 RNA recognition motif EMP24_GP25L PF01105.24 EDO18920.1 - 1.4e-39 135.9 1.7 2.1e-39 135.3 0.0 1.8 1 1 1 2 2 2 1 emp24/gp25L/p24 family/GOLD Takusan PF04822.13 EDO18920.1 - 0.059 13.3 0.7 0.12 12.2 0.7 1.5 1 0 0 1 1 1 0 Takusan Ribosomal_L33 PF00471.20 EDO18921.1 - 0.0021 18.4 0.1 0.0058 17.0 0.1 1.8 1 1 0 1 1 1 1 Ribosomal protein L33 eIF3g PF12353.8 EDO18922.1 - 8.6e-43 145.7 2.8 1.4e-42 145.0 2.8 1.3 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit G RRM_1 PF00076.22 EDO18922.1 - 3e-13 49.4 0.0 6.4e-13 48.3 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCCH_6 PF18585.1 EDO18922.1 - 0.2 11.5 0.5 0.47 10.4 0.1 1.8 2 0 0 2 2 2 0 Chromatin remodeling factor Mit1 C-terminal Zn finger 2 Rpn9_C PF18261.1 EDO18923.1 - 1.1e-18 66.5 3.9 2.3e-18 65.4 3.9 1.6 1 0 0 1 1 1 1 Rpn9 C-terminal helix PCI PF01399.27 EDO18923.1 - 5.6e-14 52.5 1.1 5.6e-14 52.5 1.1 2.3 2 0 0 2 2 2 1 PCI domain CSN8_PSD8_EIF3K PF10075.9 EDO18923.1 - 0.025 14.6 1.0 0.07 13.1 1.0 1.8 1 0 0 1 1 1 0 CSN8/PSMD8/EIF3K family PAS_9 PF13426.7 EDO18923.1 - 0.045 14.0 0.1 0.2 11.9 0.0 2.1 2 0 0 2 2 2 0 PAS domain PAP1 PF08601.10 EDO18924.1 - 2.9e-16 60.2 6.3 2.9e-16 60.2 6.3 4.2 2 1 1 3 3 3 1 Transcription factor PAP1 bZIP_1 PF00170.21 EDO18924.1 - 2.7e-06 27.4 12.6 4.2e-06 26.8 11.8 1.7 1 1 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 EDO18924.1 - 0.0003 20.8 9.3 0.00057 19.9 9.3 1.5 1 0 0 1 1 1 1 Basic region leucine zipper SLIDE PF09111.10 EDO18924.1 - 0.089 12.8 4.3 0.22 11.6 4.3 1.6 1 0 0 1 1 1 0 SLIDE bZIP_Maf PF03131.17 EDO18924.1 - 0.44 11.1 8.9 0.87 10.1 8.9 1.5 1 0 0 1 1 1 0 bZIP Maf transcription factor HrpJ PF07201.11 EDO18924.1 - 3.1 8.1 9.1 5.3 7.3 9.1 1.2 1 0 0 1 1 1 0 HrpJ-like domain AMPKBI PF04739.15 EDO18925.1 - 8.4e-18 64.4 0.1 4e-17 62.2 0.1 2.2 1 0 0 1 1 1 1 5'-AMP-activated protein kinase beta subunit, interaction domain AMPK1_CBM PF16561.5 EDO18925.1 - 3.2e-05 24.1 0.0 9.6e-05 22.5 0.0 1.8 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase zf-C2H2 PF00096.26 EDO18927.1 - 7.1e-08 32.5 12.0 0.0013 19.1 2.3 3.3 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EDO18927.1 - 4.9e-06 26.7 8.2 0.00025 21.3 5.1 2.6 2 0 0 2 2 2 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 EDO18927.1 - 0.00026 21.6 11.3 0.041 14.7 1.5 3.5 3 0 0 3 3 3 2 C2H2-type zinc finger zf-TRAF PF02176.18 EDO18927.1 - 0.76 10.5 3.3 1.5 9.6 3.3 1.4 1 0 0 1 1 1 0 TRAF-type zinc finger TFR_dimer PF04253.15 EDO18928.1 - 1.1e-16 61.0 0.0 2.2e-16 60.1 0.0 1.5 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain Peptidase_M28 PF04389.17 EDO18928.1 - 8.5e-11 41.9 0.0 1.3e-10 41.3 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.22 EDO18928.1 - 0.00011 22.1 0.0 0.00024 21.1 0.0 1.5 1 0 0 1 1 1 1 PA domain Adaptin_N PF01602.20 EDO18929.1 - 3e-110 369.2 16.5 3.8e-110 368.9 16.5 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptinC2 PF02883.20 EDO18929.1 - 1.2e-08 35.2 0.0 2.6e-08 34.2 0.0 1.6 1 0 0 1 1 1 1 Adaptin C-terminal domain HEAT PF02985.22 EDO18929.1 - 0.054 13.8 0.0 28 5.3 0.0 4.0 3 0 0 3 3 3 0 HEAT repeat bZIP_1 PF00170.21 EDO18930.1 - 2.4e-06 27.5 8.2 2.4e-06 27.5 8.2 2.6 2 1 0 2 2 2 1 bZIP transcription factor HALZ PF02183.18 EDO18930.1 - 0.0016 18.6 1.9 0.0016 18.6 1.9 1.9 2 0 0 2 2 2 1 Homeobox associated leucine zipper bZIP_2 PF07716.15 EDO18930.1 - 0.015 15.4 6.9 0.015 15.4 6.9 3.0 2 1 1 3 3 3 0 Basic region leucine zipper Hap4_Hap_bind PF10297.9 EDO18930.1 - 0.018 15.1 4.8 0.044 13.9 4.8 1.6 1 0 0 1 1 1 0 Minimal binding motif of Hap4 for binding to Hap2/3/5 MbeD_MobD PF04899.12 EDO18930.1 - 0.023 14.8 0.5 0.05 13.7 0.1 1.7 1 1 0 1 1 1 0 MbeD/MobD like bZIP_Maf PF03131.17 EDO18930.1 - 0.042 14.4 3.1 0.16 12.5 3.1 2.0 1 0 0 1 1 1 0 bZIP Maf transcription factor SlyX PF04102.12 EDO18930.1 - 0.092 13.4 0.0 0.2 12.3 0.0 1.5 1 0 0 1 1 1 0 SlyX YabA PF06156.13 EDO18930.1 - 0.24 12.1 4.4 0.31 11.7 2.2 2.4 2 1 0 2 2 2 0 Initiation control protein YabA Yip1 PF04893.17 EDO18931.1 - 0.016 14.9 3.2 0.022 14.5 3.2 1.2 1 0 0 1 1 1 0 Yip1 domain PIG-Y PF15159.6 EDO18931.1 - 3.4 8.7 9.1 2.3 9.2 4.9 2.2 2 0 0 2 2 2 0 Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y DUF2417 PF10329.9 EDO18931.1 - 8.1 5.8 27.6 4.1 6.7 13.9 2.1 1 1 1 2 2 2 0 Region of unknown function (DUF2417) Rpr2 PF04032.16 EDO18932.1 - 9.1e-13 48.3 1.6 1.5e-12 47.6 1.6 1.3 1 0 0 1 1 1 1 RNAse P Rpr2/Rpp21/SNM1 subunit domain Proteasome PF00227.26 EDO18933.1 - 1e-55 188.2 0.0 1.3e-55 187.8 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EDO18933.1 - 2.3e-13 49.5 0.2 5.9e-13 48.2 0.1 1.8 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature MATalpha_HMGbox PF04769.12 EDO18934.1 - 1.3e-13 50.7 0.2 1.3e-13 50.7 0.2 1.5 2 0 0 2 2 2 1 Mating-type protein MAT alpha 1 HMG-box Homeodomain PF00046.29 EDO18935.1 - 4.4e-07 29.6 0.6 1e-06 28.5 0.6 1.6 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EDO18935.1 - 3.9e-06 26.7 0.1 8.8e-06 25.5 0.1 1.7 1 0 0 1 1 1 1 Homeobox KN domain PALP PF00291.25 EDO18936.1 - 5e-64 216.5 0.0 5.8e-64 216.3 0.0 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Peripla_BP_4 PF13407.6 EDO18936.1 - 0.028 14.0 0.4 0.061 12.9 0.1 1.6 2 0 0 2 2 2 0 Periplasmic binding protein domain Vac17 PF17321.2 EDO18937.1 - 5.5e-146 487.5 46.7 6.2e-146 487.3 46.7 1.0 1 0 0 1 1 1 1 Vacuole-related protein 17 YlqD PF11068.8 EDO18937.1 - 0.33 11.3 0.0 0.33 11.3 0.0 2.6 2 1 1 3 3 3 0 YlqD protein MRC1 PF09444.10 EDO18938.1 - 3.2e-37 128.3 16.6 3.2e-37 128.3 16.6 6.6 3 1 5 8 8 8 1 MRC1-like domain KH_8 PF17903.1 EDO18939.1 - 3.9e-32 110.2 0.1 8.8e-32 109.0 0.1 1.6 1 0 0 1 1 1 1 Krr1 KH1 domain KH_1 PF00013.29 EDO18939.1 - 0.019 14.8 0.0 0.07 13.0 0.0 2.0 2 0 0 2 2 2 0 KH domain HTH_19 PF12844.7 EDO18940.1 - 0.024 14.7 0.3 0.024 14.7 0.3 2.0 2 0 0 2 2 2 0 Helix-turn-helix domain DUF543 PF04418.12 EDO18941.1 - 2e-32 111.0 0.1 2.4e-32 110.7 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF543) Peptidase_M3 PF01432.20 EDO18942.1 - 5.1e-146 487.5 1.1 7.3e-146 487.0 1.1 1.2 1 0 0 1 1 1 1 Peptidase family M3 MT-A70 PF05063.14 EDO18945.1 - 1.2e-11 44.9 0.1 1.7e-11 44.3 0.1 1.3 1 0 0 1 1 1 1 MT-A70 Spb1_C PF07780.12 EDO18946.1 - 1.1e-84 283.3 21.4 1.1e-84 283.3 21.4 3.2 3 0 0 3 3 3 1 Spb1 C-terminal domain FtsJ PF01728.19 EDO18946.1 - 6.1e-55 186.1 0.1 1.4e-54 184.9 0.1 1.7 1 0 0 1 1 1 1 FtsJ-like methyltransferase DUF3381 PF11861.8 EDO18946.1 - 3.8e-45 153.6 19.7 3.8e-45 153.6 19.7 5.8 5 1 1 6 6 6 1 Domain of unknown function (DUF3381) Methyltransf_23 PF13489.6 EDO18946.1 - 0.1 12.4 0.0 0.23 11.3 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain PIG-X PF08320.12 EDO18947.1 - 2.2e-33 116.0 0.0 2.9e-33 115.6 0.0 1.2 1 0 0 1 1 1 1 PIG-X / PBN1 DUF3642 PF12182.8 EDO18947.1 - 0.74 10.1 3.3 26 5.2 0.2 3.4 2 1 2 4 4 4 0 Bacterial lipoprotein ALMT PF11744.8 EDO18948.1 - 1.9 7.3 10.5 3.9 6.2 10.5 1.6 1 0 0 1 1 1 0 Aluminium activated malate transporter ATP_transf PF09830.9 EDO18949.1 - 1.9e-20 72.7 0.0 3.7e-20 71.8 0.0 1.5 1 0 0 1 1 1 1 ATP adenylyltransferase DUF4931 PF16285.5 EDO18949.1 - 5.5e-05 22.6 0.0 0.00011 21.7 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4931) Fumble PF03630.14 EDO18950.1 - 2.8e-125 417.9 4.1 3.8e-124 414.2 4.1 1.9 1 1 0 1 1 1 1 Fumble BOF PF04076.13 EDO18950.1 - 0.0055 16.7 0.0 1.9 8.6 0.0 2.4 2 0 0 2 2 2 2 Bacterial OB fold (BOF) protein Kre28 PF17097.5 EDO18951.1 - 5e-145 483.1 38.8 5.6e-145 482.9 38.8 1.0 1 0 0 1 1 1 1 Spindle pole body component Seryl_tRNA_N PF02403.22 EDO18951.1 - 0.25 11.6 23.5 0.037 14.2 5.1 4.1 3 1 1 4 4 4 0 Seryl-tRNA synthetase N-terminal domain Spc7 PF08317.11 EDO18951.1 - 7.8 5.3 27.2 0.33 9.8 7.8 3.4 2 1 1 3 3 3 0 Spc7 kinetochore protein EamA PF00892.20 EDO18952.1 - 5.2e-28 97.9 29.7 2.3e-17 63.4 5.8 2.2 2 0 0 2 2 2 2 EamA-like transporter family TPT PF03151.16 EDO18952.1 - 0.0034 16.8 2.5 0.0034 16.8 2.5 1.9 2 0 0 2 2 2 1 Triose-phosphate Transporter family RPAP1_C PF08620.10 EDO18953.1 - 9.2e-29 99.4 0.1 1.9e-28 98.3 0.1 1.6 1 0 0 1 1 1 1 RPAP1-like, C-terminal RPAP1_N PF08621.10 EDO18953.1 - 2.2e-15 56.2 8.0 2.2e-15 56.2 8.0 2.4 2 0 0 2 2 2 1 RPAP1-like, N-terminal CtIP_N PF10482.9 EDO18953.1 - 0.0045 17.0 2.2 0.012 15.6 2.2 1.7 1 0 0 1 1 1 1 Tumour-suppressor protein CtIP N-terminal domain DUF3347 PF11827.8 EDO18953.1 - 0.57 10.4 6.6 2.9 8.0 2.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3347) Pkinase PF00069.25 EDO18954.1 - 3.8e-65 219.9 0.0 5.5e-65 219.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO18954.1 - 1.6e-45 155.4 0.0 2.5e-45 154.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDO18954.1 - 4.6e-06 26.1 0.0 7.2e-05 22.2 0.0 2.1 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 EDO18954.1 - 1.2e-05 24.3 0.1 4.9e-05 22.3 0.0 1.8 2 0 0 2 2 2 1 Fungal protein kinase Recep_L_domain PF01030.24 EDO18955.1 - 2.3e-11 43.8 10.7 0.00096 19.3 0.1 4.5 2 1 1 4 4 4 3 Receptor L domain LRR_4 PF12799.7 EDO18955.1 - 4.9e-05 23.6 5.8 0.0072 16.7 1.2 4.0 3 1 0 3 3 3 2 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EDO18955.1 - 0.078 12.5 5.2 0.068 12.7 1.5 2.7 3 1 1 4 4 4 0 Leucine-rich repeat LRR_5 PF13306.6 EDO18955.1 - 0.73 9.8 10.6 0.67 9.9 0.1 3.4 2 1 0 3 3 3 0 BspA type Leucine rich repeat region (6 copies) Zn_clus PF00172.18 EDO18956.1 - 0.0002 21.4 5.5 0.00036 20.6 5.5 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain ApoA-II PF04711.13 EDO18956.1 - 0.087 13.0 0.0 0.33 11.1 0.0 2.0 1 0 0 1 1 1 0 Apolipoprotein A-II (ApoA-II) CTP_transf_like PF01467.26 EDO18957.1 - 1.4e-09 38.3 0.0 2.3e-09 37.6 0.0 1.4 1 1 0 1 1 1 1 Cytidylyltransferase-like ATP-sulfurylase PF01747.17 EDO18957.1 - 0.012 15.1 0.0 0.17 11.3 0.0 2.1 2 0 0 2 2 2 0 ATP-sulfurylase EMC1_C PF07774.13 EDO18958.1 - 2e-65 220.5 0.1 3.2e-65 219.8 0.1 1.3 1 0 0 1 1 1 1 ER membrane protein complex subunit 1, C-terminal ANAPC4_WD40 PF12894.7 EDO18958.1 - 0.0019 18.5 0.0 0.23 11.8 0.1 3.2 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.6 EDO18958.1 - 0.0049 16.5 0.0 0.012 15.2 0.0 1.6 2 0 0 2 2 2 1 PQQ-like domain PQQ PF01011.21 EDO18958.1 - 0.018 14.9 0.0 0.047 13.6 0.0 1.7 1 0 0 1 1 1 0 PQQ enzyme repeat ComGG PF14173.6 EDO18958.1 - 0.079 13.4 0.2 3.6 8.0 0.2 2.7 2 0 0 2 2 2 0 ComG operon protein 7 BspA_v PF18220.1 EDO18958.1 - 0.23 11.5 3.2 0.19 11.8 0.3 2.3 3 0 0 3 3 3 0 Adhesin BspA variable domain Mgr1 PF08602.10 EDO18959.1 - 1.3e-180 600.4 2.4 2.2e-180 599.6 2.4 1.4 1 0 0 1 1 1 1 Mgr1-like, i-AAA protease complex subunit DUF3943 PF13084.6 EDO18959.1 - 0.15 11.9 0.1 0.31 10.9 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3943) Thioredoxin PF00085.20 EDO18960.1 - 5.5e-28 97.0 1.1 7e-18 64.5 0.0 3.8 3 1 0 3 3 3 3 Thioredoxin Thioredoxin_6 PF13848.6 EDO18960.1 - 3.5e-20 72.7 17.4 1e-15 58.2 9.1 3.4 3 0 0 3 3 3 3 Thioredoxin-like domain Glyco_hydro38C2 PF17677.1 EDO18960.1 - 0.12 12.5 0.0 0.41 10.8 0.0 1.9 1 0 0 1 1 1 0 Glycosyl hydrolases family 38 C-terminal beta sandwich domain ORC_WH_C PF18137.1 EDO18960.1 - 0.78 9.8 8.2 1.5 8.8 8.2 1.5 1 0 0 1 1 1 0 Origin recognition complex winged helix C-terminal GRASP55_65 PF04495.14 EDO18961.1 - 1.3e-39 135.7 0.1 1.6e-37 128.9 0.0 2.2 1 1 1 2 2 2 2 GRASP55/65 PDZ-like domain SUIM_assoc PF16619.5 EDO18961.1 - 0.078 13.0 0.4 0.078 13.0 0.4 2.9 3 0 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 DAZAP2 PF11029.8 EDO18961.1 - 0.47 11.4 8.6 0.93 10.4 8.6 1.4 1 0 0 1 1 1 0 DAZ associated protein 2 (DAZAP2) Hexokinase_2 PF03727.16 EDO18962.1 - 2.2e-77 259.7 0.0 3.1e-77 259.3 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 EDO18962.1 - 1.3e-69 234.1 0.0 2.1e-69 233.5 0.0 1.3 1 0 0 1 1 1 1 Hexokinase T3SS_needle_E PF08988.10 EDO18962.1 - 0.13 12.5 0.1 0.28 11.4 0.1 1.5 1 0 0 1 1 1 0 Type III secretion system, cytoplasmic E component of needle RecG_N PF17190.4 EDO18962.1 - 0.28 11.9 2.0 0.73 10.6 0.1 2.7 4 0 0 4 4 4 0 RecG N-terminal helical domain WD40 PF00400.32 EDO18963.1 - 1.5e-17 63.6 3.5 0.013 16.3 0.0 6.2 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDO18963.1 - 1.9e-08 34.4 0.0 0.27 11.6 0.0 5.4 3 3 3 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EDO18963.1 - 0.004 17.1 0.1 0.22 11.4 0.0 3.3 4 0 0 4 4 4 1 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 EDO18963.1 - 0.021 14.8 0.2 3.4 7.7 0.0 3.1 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat SBP56 PF05694.11 EDO18963.1 - 0.054 12.3 0.1 0.097 11.5 0.1 1.3 1 0 0 1 1 1 0 56kDa selenium binding protein (SBP56) DUF5617 PF18493.1 EDO18963.1 - 0.28 11.3 1.9 20 5.4 0.3 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF5617) La PF05383.17 EDO18964.1 - 2.5e-17 62.6 0.3 8e-17 61.0 0.1 2.0 2 0 0 2 2 2 1 La domain Hid1 PF12722.7 EDO18964.1 - 0.26 9.4 18.6 0.45 8.6 18.6 1.3 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein CDC45 PF02724.14 EDO18964.1 - 5.4 5.2 21.5 9.2 4.4 21.5 1.4 1 0 0 1 1 1 0 CDC45-like protein DNA_pol_A_exo1 PF01612.20 EDO18965.1 - 0.014 15.1 0.0 0.071 12.8 0.0 2.2 1 1 0 1 1 1 0 3'-5' exonuclease UxaE PF16257.5 EDO18965.1 - 0.053 12.2 0.3 0.093 11.4 0.3 1.3 1 0 0 1 1 1 0 tagaturonate epimerase Glutaredoxin PF00462.24 EDO18966.1 - 6.1e-13 48.8 0.0 8.6e-13 48.3 0.0 1.2 1 0 0 1 1 1 1 Glutaredoxin Thioredoxin_7 PF13899.6 EDO18966.1 - 0.06 13.5 0.0 0.091 13.0 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin-like GAT PF03127.14 EDO18967.1 - 3e-05 24.3 1.0 0.014 15.7 0.0 3.1 3 0 0 3 3 3 2 GAT domain Pes-10 PF07149.11 EDO18967.1 - 0.026 13.6 6.5 0.05 12.7 0.3 2.1 2 0 0 2 2 2 0 Pes-10 RRM_Rrp7 PF17799.1 EDO18968.1 - 5.2e-39 133.6 4.1 5.2e-39 133.6 4.1 1.7 2 0 0 2 2 2 1 Rrp7 RRM-like N-terminal domain RRP7 PF12923.7 EDO18968.1 - 1.1e-24 86.8 8.9 1.1e-24 86.8 8.9 2.3 2 0 0 2 2 2 1 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain Lipin_mid PF16876.5 EDO18968.1 - 0.0039 17.3 0.1 0.014 15.5 0.1 2.0 1 0 0 1 1 1 1 Lipin/Ned1/Smp2 multi-domain protein middle domain Adenyl_cycl_N PF12633.7 EDO18968.1 - 0.0095 15.9 0.1 0.054 13.4 0.2 2.0 2 0 0 2 2 2 1 Adenylate cyclase NT domain DUF5093 PF17011.5 EDO18968.1 - 0.011 16.0 0.2 0.011 16.0 0.2 3.7 3 2 1 4 4 4 0 Domain of unknown function (DUF5093) DUF4279 PF14106.6 EDO18968.1 - 0.092 12.9 1.1 2.8 8.2 0.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4279) HisKA_2 PF07568.12 EDO18968.1 - 0.13 12.3 0.6 0.45 10.6 0.0 2.1 2 0 0 2 2 2 0 Histidine kinase ATP-synt_G PF04718.15 EDO18968.1 - 0.18 12.7 1.8 0.42 11.5 0.0 2.3 2 0 0 2 2 2 0 Mitochondrial ATP synthase g subunit Csm1_N PF18504.1 EDO18968.1 - 1.7 9.0 7.5 0.62 10.4 2.6 2.6 3 0 0 3 3 3 0 Csm1 N-terminal domain Complex1_LYR_2 PF13233.6 EDO18969.1 - 9.1e-21 74.4 0.9 1.2e-20 74.0 0.3 1.6 2 1 0 2 2 2 1 Complex1_LYR-like Complex1_LYR PF05347.15 EDO18969.1 - 2.1e-12 46.9 0.1 6.3e-12 45.4 0.0 1.8 2 0 0 2 2 2 1 Complex 1 protein (LYR family) DUF4028 PF13220.6 EDO18969.1 - 0.029 14.2 0.9 0.058 13.2 0.2 2.0 2 1 0 2 2 2 0 Protein of unknown function (DUF4028) Histidinol_dh PF00815.20 EDO18970.1 - 5.9e-162 539.4 2.9 5.9e-162 539.4 2.9 1.6 2 0 0 2 2 2 1 Histidinol dehydrogenase PRA-CH PF01502.18 EDO18970.1 - 1.1e-26 92.4 0.1 2.3e-26 91.4 0.1 1.5 1 0 0 1 1 1 1 Phosphoribosyl-AMP cyclohydrolase PRA-PH PF01503.17 EDO18970.1 - 3.1e-15 56.4 0.7 6.2e-15 55.4 0.7 1.6 1 0 0 1 1 1 1 Phosphoribosyl-ATP pyrophosphohydrolase SUKH_6 PF14568.6 EDO18970.1 - 0.065 13.7 0.2 0.44 11.0 0.1 2.3 2 0 0 2 2 2 0 SMI1-KNR4 cell-wall ATP-cone PF03477.16 EDO18970.1 - 0.52 10.9 2.3 0.98 10.0 0.0 2.7 3 0 0 3 3 3 0 ATP cone domain CAP_GLY PF01302.25 EDO18971.1 - 2.1e-15 56.5 0.2 4.6e-15 55.4 0.2 1.6 1 0 0 1 1 1 1 CAP-Gly domain CLIP1_ZNF PF16641.5 EDO18971.1 - 0.0015 18.4 0.3 0.0023 17.7 0.3 1.3 1 0 0 1 1 1 1 CLIP1 zinc knuckle DUF2564 PF10819.8 EDO18971.1 - 0.025 15.0 3.5 0.025 15.0 3.5 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF2564) TPR_2 PF07719.17 EDO18973.1 - 0.0028 17.7 0.0 0.018 15.1 0.0 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 EDO18973.1 - 0.04 14.1 0.0 0.31 11.3 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_16 PF13432.6 EDO18973.1 - 0.13 12.9 0.1 0.25 12.0 0.1 1.4 1 0 0 1 1 1 0 Tetratricopeptide repeat Rad60-SLD PF11976.8 EDO18974.1 - 6.5e-20 70.7 0.2 8e-20 70.5 0.2 1.1 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 EDO18974.1 - 1.5e-13 50.3 0.0 1.8e-13 50.1 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin family Pkinase PF00069.25 EDO18975.1 - 2.1e-73 246.9 0.0 5.9e-73 245.5 0.0 1.8 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO18975.1 - 7.7e-38 130.2 0.0 2.8e-37 128.4 0.0 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase Fungal_KA1 PF16797.5 EDO18975.1 - 1.3e-29 102.3 3.8 2.8e-29 101.2 2.0 2.3 2 0 0 2 2 2 1 Fungal kinase associated-1 domain Kinase-like PF14531.6 EDO18975.1 - 3.1e-05 23.4 0.0 8e-05 22.1 0.0 1.7 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 EDO18975.1 - 6.1 6.7 4.9 0.65 9.9 0.1 1.7 2 0 0 2 2 2 0 Phosphotransferase enzyme family Ank_5 PF13857.6 EDO18976.1 - 1.6e-13 50.6 0.4 9.4e-07 29.0 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 EDO18976.1 - 1.5e-10 41.5 0.1 0.00016 22.2 0.0 2.7 1 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EDO18976.1 - 3.7e-10 40.1 0.1 0.00031 21.2 0.0 3.4 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EDO18976.1 - 6.3e-10 38.4 0.2 5e-05 23.4 0.0 4.1 5 0 0 5 5 3 2 Ankyrin repeat Ank PF00023.30 EDO18976.1 - 9.5e-08 32.2 0.3 4.3e-05 23.8 0.1 2.8 2 0 0 2 2 2 1 Ankyrin repeat Nup54 PF13874.6 EDO18976.1 - 0.0046 17.1 10.8 0.39 10.8 5.2 2.3 2 0 0 2 2 2 2 Nucleoporin complex subunit 54 HIP1_clath_bdg PF16515.5 EDO18976.1 - 0.028 15.0 17.2 0.041 14.5 8.3 2.5 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 GldM_N PF12081.8 EDO18976.1 - 0.11 12.5 9.8 0.21 11.7 9.8 1.4 1 0 0 1 1 1 0 GldM N-terminal domain Atg14 PF10186.9 EDO18976.1 - 0.51 9.4 15.2 0.15 11.1 4.3 2.2 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 WXG100 PF06013.12 EDO18976.1 - 0.69 10.2 6.0 7.3 6.9 0.0 3.5 2 1 1 3 3 3 0 Proteins of 100 residues with WXG TetR_C_13 PF16925.5 EDO18976.1 - 0.84 9.6 3.5 0.83 9.6 1.3 2.1 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain YlbD_coat PF14071.6 EDO18976.1 - 1.1 9.5 9.7 1.4 9.2 0.5 3.2 1 1 2 3 3 3 0 Putative coat protein GAS PF13851.6 EDO18976.1 - 1.5 8.1 23.8 0.38 10.1 5.3 2.3 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding MerR-DNA-bind PF09278.11 EDO18976.1 - 2.7 8.6 11.2 6.6 7.4 1.8 3.1 2 1 1 3 3 3 0 MerR, DNA binding Med9 PF07544.13 EDO18976.1 - 2.8 8.1 16.9 0.51 10.5 6.2 2.5 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 KxDL PF10241.9 EDO18976.1 - 4.8 7.5 8.3 3.5 8.0 0.5 2.5 2 0 0 2 2 2 0 Uncharacterized conserved protein Spc7 PF08317.11 EDO18976.1 - 6.7 5.5 23.8 1.1 8.1 13.1 2.2 1 1 1 2 2 2 0 Spc7 kinetochore protein Homeodomain PF00046.29 EDO18977.1 - 3.2e-14 52.5 0.9 5.3e-14 51.8 0.9 1.4 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EDO18977.1 - 1.1e-06 28.5 0.2 2.2e-06 27.4 0.1 1.6 2 0 0 2 2 2 1 Homeobox KN domain Homez PF11569.8 EDO18977.1 - 0.0021 17.5 0.0 0.0041 16.6 0.0 1.4 1 0 0 1 1 1 1 Homeodomain leucine-zipper encoding, Homez DUF5100 PF17029.5 EDO18977.1 - 0.039 13.8 0.1 0.048 13.5 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5100) Sec10 PF07393.11 EDO18978.1 - 2.5e-52 178.3 20.3 4.8e-52 177.4 20.3 1.5 1 1 0 1 1 1 1 Exocyst complex component Sec10 RNase_PH PF01138.21 EDO18979.1 - 3e-29 102.2 0.0 8.8e-29 100.7 0.0 1.8 1 1 0 1 1 1 1 3' exoribonuclease family, domain 1 ELO PF01151.18 EDO18980.1 - 1.9e-59 201.2 26.9 2.7e-59 200.7 26.9 1.1 1 0 0 1 1 1 1 GNS1/SUR4 family AAA PF00004.29 EDO18981.1 - 1.4e-10 41.7 0.1 7.5e-10 39.4 0.1 2.2 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Cdc6_C PF09079.11 EDO18981.1 - 1.9e-08 34.2 0.2 5.1e-08 32.8 0.2 1.8 1 0 0 1 1 1 1 CDC6, C terminal winged helix domain AAA_22 PF13401.6 EDO18981.1 - 6.1e-08 33.0 0.0 2.2e-07 31.2 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EDO18981.1 - 3e-06 27.7 0.0 1.2e-05 25.8 0.0 2.0 1 1 0 1 1 1 1 AAA ATPase domain AAA_11 PF13086.6 EDO18981.1 - 0.0043 16.9 1.2 0.0089 15.8 0.9 1.9 1 1 0 1 1 1 1 AAA domain AAA_14 PF13173.6 EDO18981.1 - 0.0063 16.5 0.1 0.49 10.4 0.0 2.7 1 1 1 2 2 2 1 AAA domain AAA_19 PF13245.6 EDO18981.1 - 0.0069 16.7 0.8 0.029 14.7 0.0 2.4 3 1 0 3 3 3 1 AAA domain NACHT PF05729.12 EDO18981.1 - 0.0077 16.2 0.0 3.7 7.5 0.0 2.5 2 0 0 2 2 2 2 NACHT domain RNA_helicase PF00910.22 EDO18981.1 - 0.024 15.0 0.2 0.6 10.5 0.0 2.8 3 0 0 3 3 3 0 RNA helicase ATPase_2 PF01637.18 EDO18981.1 - 0.035 14.0 0.1 0.11 12.3 0.0 2.0 2 1 0 2 2 2 0 ATPase domain predominantly from Archaea T2SSE PF00437.20 EDO18981.1 - 0.089 11.8 0.1 0.17 11.0 0.1 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_5 PF07728.14 EDO18981.1 - 0.11 12.5 0.0 8.2 6.4 0.0 2.7 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) TPT PF03151.16 EDO18982.1 - 4.4e-34 118.2 16.5 2.2e-32 112.6 16.5 2.2 1 1 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 EDO18982.1 - 0.021 15.0 39.4 0.043 14.0 12.8 4.3 3 2 2 5 5 5 0 EamA-like transporter family Beach PF02138.18 EDO18983.1 - 4.6e-118 393.6 0.1 1.1e-117 392.3 0.1 1.7 1 0 0 1 1 1 1 Beige/BEACH domain PH_BEACH PF14844.6 EDO18983.1 - 2.3e-11 43.6 0.4 9e-11 41.8 0.0 2.4 2 0 0 2 2 2 1 PH domain associated with Beige/BEACH Atx10homo_assoc PF09759.9 EDO18983.1 - 0.062 13.3 0.2 0.3 11.2 0.2 2.3 1 0 0 1 1 1 0 Spinocerebellar ataxia type 10 protein domain Arm_3 PF16186.5 EDO18983.1 - 0.13 11.8 4.8 4.8 6.8 0.3 3.3 2 0 0 2 2 2 0 Atypical Arm repeat DUF2996 PF11210.8 EDO18983.1 - 0.71 10.3 6.9 0.32 11.4 0.1 3.6 3 1 1 4 4 4 0 Protein of unknown function (DUF2996) SOP4 PF17081.5 EDO18984.1 - 1.2e-93 312.4 0.8 1.4e-93 312.2 0.8 1.0 1 0 0 1 1 1 1 Suppressor of PMA 1-7 protein Ribosomal_S11 PF00411.19 EDO18985.1 - 7.6e-46 155.1 2.0 9.2e-46 154.8 2.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S11 BKACE PF05853.12 EDO18985.1 - 0.072 12.4 0.3 0.087 12.1 0.3 1.1 1 0 0 1 1 1 0 beta-keto acid cleavage enzyme Mannosyl_trans3 PF11051.8 EDO18986.1 - 2.2e-80 269.9 0.0 3.8e-80 269.2 0.0 1.4 1 0 0 1 1 1 1 Mannosyltransferase putative muHD PF10291.9 EDO18987.1 - 2.8e-79 266.3 0.0 5.9e-79 265.2 0.0 1.6 1 0 0 1 1 1 1 Muniscin C-terminal mu homology domain DUF4806 PF16064.5 EDO18987.1 - 0.026 14.8 0.2 0.093 13.0 0.2 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4806) FCH PF00611.23 EDO18987.1 - 0.086 13.1 0.3 0.23 11.8 0.3 1.7 1 0 0 1 1 1 0 Fes/CIP4, and EFC/F-BAR homology domain SSB PF00436.25 EDO18989.1 - 6.2e-21 74.4 0.1 7.5e-21 74.1 0.1 1.1 1 0 0 1 1 1 1 Single-strand binding protein family CHU_C PF13585.6 EDO18989.1 - 0.031 14.3 1.0 0.12 12.4 0.4 1.9 1 1 1 2 2 2 0 C-terminal domain of CHU protein family MFS_1 PF07690.16 EDO18990.1 - 6e-27 94.5 18.7 8.3e-27 94.0 18.7 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF3792 PF12670.7 EDO18990.1 - 9.7e-06 25.7 4.2 0.00014 22.0 1.8 2.9 3 0 0 3 3 3 1 Protein of unknown function (DUF3792) MFS_4 PF06779.14 EDO18990.1 - 4.7e-05 22.8 7.5 4.8e-05 22.8 0.2 2.1 2 0 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB Glyco_transf_34 PF05637.12 EDO18991.1 - 9.2e-49 166.3 0.1 1.3e-48 165.9 0.1 1.2 1 0 0 1 1 1 1 galactosyl transferase GMA12/MNN10 family Prefoldin_2 PF01920.20 EDO18992.1 - 1.6e-12 47.3 8.7 1.8e-12 47.2 8.7 1.1 1 0 0 1 1 1 1 Prefoldin subunit NPV_P10 PF05531.12 EDO18992.1 - 0.014 15.9 6.2 0.78 10.2 1.9 2.1 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein PRKG1_interact PF15898.5 EDO18992.1 - 0.021 15.7 2.7 0.032 15.1 2.7 1.2 1 0 0 1 1 1 0 cGMP-dependent protein kinase interacting domain HlyD_2 PF12700.7 EDO18992.1 - 0.03 13.1 5.1 0.033 13.0 5.1 1.0 1 0 0 1 1 1 0 HlyD family secretion protein Seryl_tRNA_N PF02403.22 EDO18992.1 - 0.26 11.5 4.6 0.91 9.8 4.1 1.9 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain DUF3450 PF11932.8 EDO18992.1 - 0.39 10.0 7.6 0.38 10.0 0.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) Prominin PF05478.11 EDO18992.1 - 0.47 8.3 5.4 0.49 8.3 5.4 1.0 1 0 0 1 1 1 0 Prominin YabA PF06156.13 EDO18992.1 - 0.82 10.3 5.6 3.8 8.2 0.1 2.1 1 1 0 2 2 2 0 Initiation control protein YabA TMF_TATA_bd PF12325.8 EDO18992.1 - 4.6 7.5 11.0 4.9 7.4 2.7 2.4 2 1 0 3 3 3 0 TATA element modulatory factor 1 TATA binding ATG27 PF09451.10 EDO18993.1 - 2.5e-45 155.4 0.0 3e-45 155.1 0.0 1.0 1 0 0 1 1 1 1 Autophagy-related protein 27 Phage_holin_2_2 PF10746.9 EDO18993.1 - 0.15 11.8 4.0 0.26 11.0 1.0 2.5 3 0 0 3 3 3 0 Phage holin T7 family, holin superfamily II FixP_N PF14715.6 EDO18993.1 - 2.7 7.8 7.9 6 6.7 7.9 1.5 1 0 0 1 1 1 0 N-terminal domain of cytochrome oxidase-cbb3, FixP Ribosomal_L22 PF00237.19 EDO18994.1 - 1.5e-38 131.2 2.2 3.4e-38 130.0 0.1 1.9 2 0 0 2 2 2 1 Ribosomal protein L22p/L17e CASP_C PF08172.12 EDO18995.1 - 3.2e-60 203.6 3.0 3.2e-60 203.6 3.0 4.5 4 1 1 5 5 5 1 CASP C terminal Lipoprotein_20 PF13942.6 EDO18995.1 - 0.011 15.7 3.1 0.011 15.7 3.1 5.5 4 2 3 7 7 7 0 YfhG lipoprotein NPV_P10 PF05531.12 EDO18995.1 - 0.036 14.5 0.7 0.036 14.5 0.7 6.2 4 2 2 7 7 7 0 Nucleopolyhedrovirus P10 protein DUF3251 PF11622.8 EDO18995.1 - 0.18 11.4 5.3 7.1 6.2 0.0 4.0 3 1 1 4 4 4 0 Protein of unknown function (DUF3251) DASH_Dam1 PF08653.10 EDO18995.1 - 0.25 11.2 10.8 0.24 11.2 0.4 4.4 4 0 0 4 4 4 0 DASH complex subunit Dam1 Rep_fac-A_3 PF08661.11 EDO18996.1 - 1.4e-26 92.8 0.0 1.6e-26 92.7 0.0 1.0 1 0 0 1 1 1 1 Replication factor A protein 3 Lon_2 PF13337.6 EDO18996.1 - 0.15 10.6 0.0 0.17 10.4 0.0 1.2 1 0 0 1 1 1 0 Putative ATP-dependent Lon protease DUF2401 PF10287.9 EDO18997.1 - 3.3e-80 269.0 3.0 4.8e-80 268.4 3.0 1.2 1 0 0 1 1 1 1 Putative TOS1-like glycosyl hydrolase (DUF2401) DUF2403 PF10290.9 EDO18997.1 - 1.4e-23 83.1 0.1 3.2e-23 81.9 0.1 1.7 1 0 0 1 1 1 1 Glycine-rich protein domain (DUF2403) Longin_2 PF18639.1 EDO18998.1 - 1.9e-65 219.7 0.2 1.9e-65 219.7 0.2 2.0 2 0 0 2 2 2 1 Yeast longin domain AA_permease PF00324.21 EDO18999.1 - 5.3e-81 272.6 47.5 7e-81 272.2 47.5 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EDO18999.1 - 4.9e-38 131.1 51.6 6.5e-38 130.7 51.6 1.0 1 0 0 1 1 1 1 Amino acid permease MMPL PF03176.15 EDO18999.1 - 2.8 6.8 5.1 0.64 8.9 1.1 1.9 2 0 0 2 2 2 0 MMPL family DUF423 PF04241.15 EDO18999.1 - 6.5 7.0 8.1 8.3 6.7 0.4 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF423) polyprenyl_synt PF00348.17 EDO19000.1 - 3.6e-99 331.0 0.1 4.3e-99 330.7 0.1 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase DIT1_PvcA PF05141.12 EDO19000.1 - 0.047 13.2 0.1 0.089 12.2 0.1 1.5 2 0 0 2 2 2 0 Pyoverdine/dityrosine biosynthesis protein UcrQ PF02939.16 EDO19001.1 - 5e-33 112.9 0.9 5.8e-33 112.7 0.9 1.1 1 0 0 1 1 1 1 UcrQ family Cyt_b-c1_8 PF10890.8 EDO19001.1 - 0.0058 17.0 0.1 0.0077 16.6 0.1 1.3 1 0 0 1 1 1 1 Cytochrome b-c1 complex subunit 8 Ribosomal_L14 PF00238.19 EDO19002.1 - 8.2e-41 138.9 2.6 9.2e-41 138.8 2.6 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e L51_S25_CI-B8 PF05047.16 EDO19003.1 - 6.8e-14 51.5 0.4 6.8e-14 51.5 0.4 1.9 3 0 0 3 3 3 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain DUF3458 PF11940.8 EDO19003.1 - 0.056 13.9 0.0 0.088 13.3 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3458) Ig-like fold Peripla_BP_7 PF18610.1 EDO19003.1 - 0.076 13.2 0.1 0.83 9.8 0.0 2.1 1 1 1 2 2 2 0 Periplasmic binding protein domain Pkinase PF00069.25 EDO19004.1 - 8e-72 241.8 0.0 1.1e-71 241.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO19004.1 - 1.4e-39 136.0 0.0 1.9e-39 135.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDO19004.1 - 0.0035 16.7 0.0 0.0074 15.6 0.0 1.5 1 1 0 1 1 1 1 Kinase-like FTA2 PF13095.6 EDO19004.1 - 0.0056 16.3 0.0 0.22 11.1 0.0 2.2 2 0 0 2 2 2 1 Kinetochore Sim4 complex subunit FTA2 Haspin_kinase PF12330.8 EDO19004.1 - 0.021 13.8 0.0 0.032 13.2 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain APH PF01636.23 EDO19004.1 - 0.075 12.9 0.0 0.17 11.8 0.0 1.5 1 1 0 1 1 1 0 Phosphotransferase enzyme family PIR PF00399.19 EDO19005.1 - 2.6e-21 74.6 24.1 2e-07 30.4 3.2 3.6 3 0 0 3 3 3 3 Yeast PIR protein repeat PIR PF00399.19 EDO19006.1 - 1.8e-50 167.5 87.7 1.1e-08 34.4 5.7 7.1 6 0 0 6 6 6 6 Yeast PIR protein repeat PP2C_2 PF13672.6 EDO19006.1 - 0.019 14.6 19.1 11 5.6 0.2 4.5 1 1 2 3 3 3 0 Protein phosphatase 2C TFIIA PF03153.13 EDO19006.1 - 1.9 8.4 17.2 2.2 8.2 17.2 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Macoilin PF09726.9 EDO19006.1 - 4 5.9 10.8 4.9 5.6 10.8 1.1 1 0 0 1 1 1 0 Macoilin family Pirin_C PF05726.13 EDO19006.1 - 4.2 7.8 5.4 22 5.5 0.3 2.9 1 1 2 3 3 3 0 Pirin C-terminal cupin domain PIR PF00399.19 EDO19007.1 - 2.4e-48 160.7 78.4 4.4e-09 35.7 2.8 6.8 6 0 0 6 6 6 6 Yeast PIR protein repeat DUF374 PF04028.13 EDO19007.1 - 0.027 14.0 4.0 12 5.5 0.4 4.7 1 1 4 5 5 5 0 Domain of unknown function (DUF374) TFIIA PF03153.13 EDO19007.1 - 0.72 9.8 15.1 0.86 9.5 15.1 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Hamartin PF04388.12 EDO19007.1 - 0.99 8.0 14.8 1.2 7.7 14.8 1.0 1 0 0 1 1 1 0 Hamartin protein Vps35 PF03635.17 EDO19008.1 - 1.2e-215 718.4 44.9 1.8e-215 717.7 44.9 1.2 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 35 peroxidase PF00141.23 EDO19009.1 - 5.1e-40 137.6 0.0 9.7e-40 136.7 0.0 1.5 1 1 0 1 1 1 1 Peroxidase Pam17 PF08566.10 EDO19010.1 - 7.1e-68 227.6 0.1 8.5e-68 227.4 0.1 1.0 1 0 0 1 1 1 1 Mitochondrial import protein Pam17 BPD_transp_2 PF02653.16 EDO19010.1 - 0.012 14.8 0.0 0.016 14.4 0.0 1.1 1 0 0 1 1 1 0 Branched-chain amino acid transport system / permease component Pmp3 PF01679.17 EDO19011.1 - 2.1e-16 59.8 5.4 2.8e-16 59.5 5.4 1.1 1 0 0 1 1 1 1 Proteolipid membrane potential modulator F-box-like PF12937.7 EDO19012.1 - 7.7e-08 32.1 0.6 2.4e-07 30.5 0.6 1.9 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EDO19012.1 - 7.5e-05 22.5 2.4 0.00012 21.9 0.4 2.5 2 0 0 2 2 2 1 F-box domain Ribonuc_red_sm PF00268.21 EDO19013.1 - 9.6e-82 274.6 6.0 1.2e-81 274.2 6.0 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, small chain zf-TRAF PF02176.18 EDO19013.1 - 0.005 17.5 0.1 0.0098 16.6 0.1 1.4 1 0 0 1 1 1 1 TRAF-type zinc finger Ribonuc_red_sm PF00268.21 EDO19014.1 - 1.7e-115 385.3 2.6 2.2e-115 384.9 2.6 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, small chain DUF4744 PF15918.5 EDO19014.1 - 0.11 13.3 0.1 0.32 11.9 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4744) Cep57_CLD_2 PF14197.6 EDO19014.1 - 0.13 12.4 4.4 0.26 11.4 4.4 1.5 1 0 0 1 1 1 0 Centrosome localisation domain of PPC89 MFS_1 PF07690.16 EDO19015.1 - 1.5e-35 122.8 27.8 1.5e-35 122.8 27.8 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 EDO19015.1 - 2.3e-05 23.0 2.9 2.3e-05 23.0 2.9 1.5 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 EDO19015.1 - 0.00018 20.5 27.5 0.0006 18.8 27.6 1.8 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_4 PF06779.14 EDO19015.1 - 0.00094 18.6 2.1 0.00094 18.6 2.1 1.7 2 0 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB Speriolin_C PF15059.6 EDO19016.1 - 0.0033 17.5 5.0 0.0054 16.9 2.3 2.4 2 1 0 2 2 2 1 Speriolin C-terminus CTV_P23 PF04808.12 EDO19016.1 - 0.024 14.2 0.6 0.04 13.5 0.6 1.4 1 0 0 1 1 1 0 Citrus tristeza virus (CTV) P23 protein CRISPR_Cas2 PF09827.9 EDO19016.1 - 0.073 13.3 2.0 0.55 10.5 0.4 2.8 2 1 0 2 2 2 0 CRISPR associated protein Cas2 LsmAD PF06741.13 EDO19017.1 - 1.3e-30 105.7 0.4 1.3e-30 105.7 0.4 3.9 3 1 1 4 4 4 1 LsmAD domain SM-ATX PF14438.6 EDO19017.1 - 1.3e-13 50.9 0.1 5.1e-13 49.0 0.1 2.1 1 0 0 1 1 1 1 Ataxin 2 SM domain LSM14 PF12701.7 EDO19017.1 - 0.0072 16.4 0.3 0.016 15.3 0.3 1.6 1 0 0 1 1 1 1 Scd6-like Sm domain NESP55 PF06390.12 EDO19017.1 - 2.4 7.7 17.7 7 6.2 17.7 1.9 1 0 0 1 1 1 0 Neuroendocrine-specific golgi protein P55 (NESP55) Trypan_PARP PF05887.11 EDO19017.1 - 4.6 7.2 10.5 3 7.8 8.3 1.9 1 1 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) AATase PF07247.12 EDO19018.1 - 3.7e-174 580.0 8.1 4.2e-174 579.8 8.1 1.0 1 0 0 1 1 1 1 Alcohol acetyltransferase SE PF08491.10 EDO19019.1 - 3.7e-116 387.0 0.0 4.8e-116 386.6 0.0 1.1 1 0 0 1 1 1 1 Squalene epoxidase FAD_binding_3 PF01494.19 EDO19019.1 - 1.6e-12 47.3 0.0 2.6e-12 46.7 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 EDO19019.1 - 1.4e-06 28.2 0.1 3.8e-05 23.4 0.1 2.2 2 1 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EDO19019.1 - 0.00092 19.4 0.1 0.0018 18.5 0.1 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 EDO19019.1 - 0.0011 19.5 0.9 0.0019 18.7 0.1 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EDO19019.1 - 0.0013 17.9 0.7 0.0051 15.9 0.5 1.8 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_2 PF07992.14 EDO19019.1 - 0.0029 16.9 0.2 0.0074 15.5 0.0 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.18 EDO19019.1 - 0.011 15.6 0.1 0.019 14.8 0.1 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain FAD_oxidored PF12831.7 EDO19019.1 - 0.013 14.9 1.4 0.015 14.7 0.5 1.5 2 0 0 2 2 2 0 FAD dependent oxidoreductase Shikimate_DH PF01488.20 EDO19019.1 - 0.013 15.6 0.0 0.023 14.7 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Thi4 PF01946.17 EDO19019.1 - 0.017 14.4 0.0 0.034 13.4 0.0 1.4 1 0 0 1 1 1 0 Thi4 family GDI PF00996.18 EDO19019.1 - 0.045 12.3 0.0 0.09 11.3 0.0 1.4 1 0 0 1 1 1 0 GDP dissociation inhibitor ApbA PF02558.16 EDO19019.1 - 0.07 12.8 0.0 0.13 11.9 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA UDPG_MGDP_dh_N PF03721.14 EDO19019.1 - 0.12 11.9 0.1 0.42 10.2 0.1 1.8 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain GIDA PF01134.22 EDO19019.1 - 0.13 11.3 0.3 0.48 9.4 0.1 1.8 2 0 0 2 2 2 0 Glucose inhibited division protein A HI0933_like PF03486.14 EDO19019.1 - 0.23 10.1 0.2 0.56 8.8 0.0 1.6 2 0 0 2 2 2 0 HI0933-like protein CBP4 PF07960.11 EDO19020.1 - 8.3e-57 190.6 5.5 9.7e-57 190.4 5.5 1.0 1 0 0 1 1 1 1 CBP4 DUF600 PF04634.12 EDO19020.1 - 0.0052 16.8 0.3 0.032 14.3 0.0 1.9 1 1 1 2 2 2 1 Protein of unknown function, DUF600 DUF4574 PF15141.6 EDO19020.1 - 0.0078 16.1 6.1 0.0084 16.0 0.1 2.4 1 1 2 3 3 3 1 Ubiquinol-cytochrome-c reductase complex assembly factor 3 LAMTOR PF15454.6 EDO19020.1 - 0.18 12.5 0.7 0.18 12.5 0.7 2.2 2 0 0 2 2 2 0 Late endosomal/lysosomal adaptor and MAPK and MTOR activator DUF4407 PF14362.6 EDO19020.1 - 1.3 8.4 6.1 1.5 8.1 6.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) UCR_UQCRX_QCR9 PF05365.12 EDO19021.1 - 3.2e-25 87.8 1.2 3.6e-25 87.6 1.2 1.0 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like zf-UBR PF02207.20 EDO19022.1 - 2.5e-17 62.8 12.9 2.5e-17 62.8 12.9 2.6 2 0 0 2 2 2 1 Putative zinc finger in N-recognin (UBR box) ClpS PF02617.17 EDO19022.1 - 0.00071 19.3 0.0 0.0021 17.8 0.0 1.8 1 0 0 1 1 1 1 ATP-dependent Clp protease adaptor protein ClpS zf-RING_2 PF13639.6 EDO19022.1 - 0.0039 17.5 0.9 0.0039 17.5 0.9 3.6 3 0 0 3 3 3 1 Ring finger domain zf-rbx1 PF12678.7 EDO19022.1 - 0.027 14.8 0.1 0.027 14.8 0.1 2.5 3 0 0 3 3 3 0 RING-H2 zinc finger domain Vps39_2 PF10367.9 EDO19022.1 - 0.059 13.8 0.6 0.43 11.0 0.6 2.6 1 0 0 1 1 1 0 Vacuolar sorting protein 39 domain 2 zf-C3HC4_2 PF13923.6 EDO19022.1 - 0.35 10.7 4.6 0.82 9.6 1.3 3.2 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) HlyIII PF03006.20 EDO19023.1 - 3.1e-61 206.9 17.0 4e-61 206.6 17.0 1.1 1 0 0 1 1 1 1 Haemolysin-III related SBDS PF01172.18 EDO19024.1 - 1.4e-34 118.0 2.0 2.4e-34 117.3 2.0 1.4 1 0 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein SBDS_C PF09377.10 EDO19024.1 - 4.1e-29 101.0 1.5 4.1e-29 101.0 1.5 1.7 2 0 0 2 2 2 1 SBDS protein C-terminal domain POC3_POC4 PF10448.9 EDO19025.1 - 3.9e-46 156.6 3.0 4.4e-46 156.5 3.0 1.0 1 0 0 1 1 1 1 20S proteasome chaperone assembly proteins 3 and 4 Abhydro_lipase PF04083.16 EDO19026.1 - 2.4e-16 59.1 0.0 4.4e-16 58.2 0.0 1.5 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region Abhydrolase_1 PF00561.20 EDO19026.1 - 1.2e-09 38.2 0.1 2.4e-09 37.2 0.1 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EDO19026.1 - 4.4e-06 26.1 0.0 1e-05 24.9 0.0 1.6 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EDO19026.1 - 0.0048 17.5 0.0 0.0069 17.0 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Sof1 PF04158.14 EDO19027.1 - 4e-29 100.7 16.4 4e-29 100.7 16.4 2.5 2 0 0 2 2 2 1 Sof1-like domain WD40 PF00400.32 EDO19027.1 - 8.4e-27 92.9 6.9 1.8e-06 28.6 0.0 6.3 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDO19027.1 - 1.5e-07 31.6 0.6 0.084 13.2 0.0 5.4 2 2 4 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EDO19027.1 - 3.9e-07 29.4 1.4 0.0028 16.7 0.0 3.5 2 1 2 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein BBS2_Mid PF14783.6 EDO19027.1 - 0.011 15.8 0.5 0.29 11.2 0.0 3.2 3 2 1 4 4 4 0 Ciliary BBSome complex subunit 2, middle region NIF PF03031.18 EDO19028.1 - 3.6e-53 179.5 0.1 3.6e-53 179.5 0.1 1.7 2 0 0 2 2 2 1 NLI interacting factor-like phosphatase UPF0258 PF06789.12 EDO19028.1 - 0.0043 17.2 0.1 0.0043 17.2 0.1 2.7 2 0 0 2 2 2 1 Uncharacterised protein family (UPF0258) NPCC PF08058.11 EDO19029.1 - 2.7e-34 118.0 3.3 5.1e-34 117.1 3.3 1.5 1 0 0 1 1 1 1 Nuclear pore complex component PNP_UDP_1 PF01048.20 EDO19030.1 - 4.1e-32 111.3 0.0 5.9e-32 110.8 0.0 1.3 1 0 0 1 1 1 1 Phosphorylase superfamily COX17 PF05051.13 EDO19031.1 - 5.8e-21 74.6 7.8 7.1e-21 74.3 7.8 1.1 1 0 0 1 1 1 1 Cytochrome C oxidase copper chaperone (COX17) CHCH PF06747.13 EDO19031.1 - 0.0017 18.5 3.7 0.0028 17.8 3.7 1.5 1 0 0 1 1 1 1 CHCH domain Cmc1 PF08583.10 EDO19031.1 - 0.013 15.6 7.9 0.043 13.8 0.2 2.1 1 1 1 2 2 2 0 Cytochrome c oxidase biogenesis protein Cmc1 like PH_12 PF16457.5 EDO19032.1 - 4e-09 37.1 6.1 0.0014 19.2 0.0 3.7 3 1 1 4 4 4 2 Pleckstrin homology domain MMM1 PF10296.9 EDO19033.1 - 1.4e-140 468.1 1.8 1.7e-140 467.8 1.8 1.1 1 0 0 1 1 1 1 Maintenance of mitochondrial morphology protein 1 Ribophorin_I PF04597.14 EDO19034.1 - 3.9e-122 408.6 5.5 4.4e-122 408.5 5.5 1.0 1 0 0 1 1 1 1 Ribophorin I Sfi1_C PF10638.9 EDO19035.1 - 1.9e-37 128.2 2.0 1.9e-37 128.2 2.0 3.5 5 0 0 5 5 5 1 Spindle body associated protein C-terminus Sfi1 PF08457.10 EDO19035.1 - 1.4e-25 89.9 58.4 3e-22 78.9 39.9 3.9 1 1 0 2 2 2 2 Sfi1 spindle body protein Proteasome PF00227.26 EDO19036.1 - 2.4e-49 167.4 0.9 2.8e-49 167.2 0.9 1.0 1 0 0 1 1 1 1 Proteasome subunit Dynamin_M PF01031.20 EDO19037.1 - 2.6e-107 358.3 1.2 7.6e-107 356.8 0.0 2.1 2 0 0 2 2 2 1 Dynamin central region Dynamin_N PF00350.23 EDO19037.1 - 2.1e-56 190.6 0.2 1.3e-54 184.8 0.0 3.3 2 1 0 2 2 2 1 Dynamin family GED PF02212.18 EDO19037.1 - 5.5e-29 100.2 4.4 1.7e-28 98.6 4.4 1.9 1 0 0 1 1 1 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.23 EDO19037.1 - 8.8e-05 22.6 0.6 0.11 12.6 0.2 2.8 2 0 0 2 2 2 2 50S ribosome-binding GTPase SLAIN PF15301.6 EDO19037.1 - 0.75 9.0 4.8 0.18 11.0 1.1 1.7 2 0 0 2 2 2 0 SLAIN motif-containing family AAA_21 PF13304.6 EDO19037.1 - 0.78 9.5 7.6 0.11 12.3 3.2 1.9 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system SH3_1 PF00018.28 EDO19038.1 - 1.5e-13 50.1 0.0 3.4e-13 49.0 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EDO19038.1 - 1.6e-10 40.7 0.1 5.4e-10 39.0 0.1 2.0 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EDO19038.1 - 3.7e-07 29.7 0.0 6.8e-07 28.9 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain DUF3246 PF11596.8 EDO19038.1 - 8.6 5.7 11.9 29 4.0 8.2 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3246) Cwf_Cwc_15 PF04889.12 EDO19039.1 - 7.4e-23 81.6 33.6 1.3e-13 51.2 27.2 2.8 1 1 1 2 2 2 2 Cwf15/Cwc15 cell cycle control protein HABP4_PAI-RBP1 PF04774.15 EDO19039.1 - 0.02 15.7 8.4 0.038 14.8 8.4 1.5 1 0 0 1 1 1 0 Hyaluronan / mRNA binding family Astro_capsid_p PF12226.8 EDO19039.1 - 0.11 11.6 9.1 0.14 11.3 9.1 1.1 1 0 0 1 1 1 0 Turkey astrovirus capsid protein FAM220 PF15487.6 EDO19039.1 - 0.19 11.4 3.7 0.34 10.5 3.7 1.4 1 0 0 1 1 1 0 FAM220 family RNA_pol_3_Rpc31 PF11705.8 EDO19039.1 - 0.44 10.8 17.5 0.073 13.3 13.6 1.6 2 0 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 NOA36 PF06524.12 EDO19039.1 - 0.45 9.8 17.8 0.041 13.2 13.1 1.5 2 0 0 2 2 2 0 NOA36 protein DNA_pol_phi PF04931.13 EDO19039.1 - 2.1 6.3 16.4 2.6 6.0 16.4 1.2 1 0 0 1 1 1 0 DNA polymerase phi YL1 PF05764.13 EDO19039.1 - 2.4 8.2 22.7 1.2 9.2 20.5 1.5 1 1 0 1 1 1 0 YL1 nuclear protein TRAP_alpha PF03896.16 EDO19039.1 - 3.8 6.6 7.0 5 6.2 7.0 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit CDC45 PF02724.14 EDO19039.1 - 9.2 4.4 12.7 9.7 4.3 12.7 1.1 1 0 0 1 1 1 0 CDC45-like protein Rho_GDI PF02115.17 EDO19041.1 - 2.3e-59 200.5 0.7 2.7e-59 200.2 0.7 1.0 1 0 0 1 1 1 1 RHO protein GDP dissociation inhibitor Metallophos PF00149.28 EDO19042.1 - 1e-33 117.6 0.4 1.8e-33 116.8 0.4 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Mit_KHE1 PF10173.9 EDO19043.1 - 6.4e-45 153.6 4.0 1.8e-44 152.2 4.0 1.6 1 1 0 1 1 1 1 Mitochondrial K+-H+ exchange-related BPS1 PF05633.11 EDO19043.1 - 0.021 13.9 0.0 0.037 13.0 0.0 1.4 1 0 0 1 1 1 0 Protein BYPASS1-related MARVEL PF01284.23 EDO19044.1 - 0.03 14.3 1.4 0.066 13.2 1.4 1.5 1 1 0 1 1 1 0 Membrane-associating domain Cullin PF00888.22 EDO19045.1 - 2.9e-52 178.2 9.0 3.5e-52 177.9 9.0 1.0 1 0 0 1 1 1 1 Cullin family Cullin PF00888.22 EDO19046.1 - 5.2e-91 306.1 2.8 7.3e-91 305.7 0.1 1.9 2 0 0 2 2 2 1 Cullin family Cullin_Nedd8 PF10557.9 EDO19046.1 - 1.3e-23 82.8 4.0 2.3e-23 82.0 1.6 2.5 2 0 0 2 2 2 1 Cullin protein neddylation domain SH3BP5 PF05276.14 EDO19046.1 - 0.013 15.3 2.2 0.024 14.5 2.2 1.3 1 0 0 1 1 1 0 SH3 domain-binding protein 5 (SH3BP5) Penicillinase_R PF03965.16 EDO19046.1 - 0.033 14.5 0.1 0.13 12.7 0.0 2.1 2 0 0 2 2 2 0 Penicillinase repressor Rpn3_C PF08375.11 EDO19046.1 - 0.12 12.8 0.0 0.33 11.4 0.0 1.8 1 0 0 1 1 1 0 Proteasome regulatory subunit C-terminal WAC_Acf1_DNA_bd PF10537.9 EDO19046.1 - 0.28 11.7 1.9 1.1 9.8 0.4 2.6 2 1 1 3 3 3 0 ATP-utilising chromatin assembly and remodelling N-terminal HMGL-like PF00682.19 EDO19047.1 - 1.6e-85 286.8 0.1 2.4e-85 286.3 0.1 1.3 1 0 0 1 1 1 1 HMGL-like Ribosomal_60s PF00428.19 EDO19048.1 - 2.3e-24 85.8 11.2 2.7e-24 85.6 11.2 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein Sigma70_ner PF04546.13 EDO19048.1 - 0.088 12.7 0.3 0.1 12.4 0.3 1.1 1 0 0 1 1 1 0 Sigma-70, non-essential region Na_Ca_ex PF01699.24 EDO19049.1 - 6.1e-47 159.4 36.2 3.6e-24 85.4 11.1 2.2 2 0 0 2 2 2 2 Sodium/calcium exchanger protein YWFCY PF14293.6 EDO19049.1 - 0.4 11.0 0.1 0.4 11.0 0.1 2.4 3 0 0 3 3 3 0 YWFCY protein Tad PF13400.6 EDO19049.1 - 5.2 7.5 8.2 0.45 10.9 0.3 3.4 3 0 0 3 3 3 0 Putative Flp pilus-assembly TadE/G-like Cyclin_N PF00134.23 EDO19050.1 - 2.3e-14 53.2 0.0 4.6e-14 52.3 0.0 1.5 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.11 EDO19050.1 - 3.4e-05 24.3 0.1 3.4e-05 24.3 0.1 2.3 2 1 0 2 2 2 1 Cyclin AAA PF00004.29 EDO19051.1 - 1.1e-97 323.6 0.0 5.7e-48 162.7 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EDO19051.1 - 6.8e-26 89.8 6.1 7.7e-14 51.2 1.3 2.7 2 0 0 2 2 2 2 AAA+ lid domain CDC48_N PF02359.18 EDO19051.1 - 7.3e-19 67.7 0.5 2.3e-18 66.2 0.5 1.9 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), N-terminal domain RuvB_N PF05496.12 EDO19051.1 - 6.8e-14 51.9 0.0 1.2e-05 25.1 0.0 2.8 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 EDO19051.1 - 2e-13 50.8 0.0 3.2e-07 30.6 0.0 2.8 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 EDO19051.1 - 4.6e-13 49.9 0.1 0.00012 22.5 0.0 4.6 3 2 0 3 3 2 2 AAA ATPase domain AAA_5 PF07728.14 EDO19051.1 - 3.9e-12 46.3 0.5 7.8e-06 25.9 0.1 3.8 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 EDO19051.1 - 2.4e-11 44.0 0.0 1.3e-05 25.4 0.0 2.9 2 0 0 2 2 2 2 AAA domain TIP49 PF06068.13 EDO19051.1 - 3.3e-09 36.4 0.0 0.0016 17.7 0.0 2.4 2 0 0 2 2 2 2 TIP49 P-loop domain CDC48_2 PF02933.17 EDO19051.1 - 4.2e-09 36.1 0.0 1e-08 34.8 0.0 1.7 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), domain 2 AAA_22 PF13401.6 EDO19051.1 - 1.3e-08 35.2 0.8 0.072 13.4 0.1 4.0 2 2 1 3 3 3 2 AAA domain RNA_helicase PF00910.22 EDO19051.1 - 2.5e-07 31.0 0.0 0.013 15.9 0.0 3.1 2 0 0 2 2 2 2 RNA helicase Mg_chelatase PF01078.21 EDO19051.1 - 4.8e-07 29.4 0.5 0.037 13.4 0.0 2.7 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_14 PF13173.6 EDO19051.1 - 7.2e-07 29.3 0.0 0.025 14.6 0.0 2.6 2 0 0 2 2 2 2 AAA domain Vps4_C PF09336.10 EDO19051.1 - 8.4e-07 28.9 2.2 2.6e-05 24.1 0.3 3.1 3 0 0 3 3 2 1 Vps4 C terminal oligomerisation domain IstB_IS21 PF01695.17 EDO19051.1 - 1e-06 28.6 0.0 0.031 14.0 0.0 2.8 2 0 0 2 2 2 2 IstB-like ATP binding protein ATPase PF06745.13 EDO19051.1 - 2e-06 27.3 0.9 0.48 9.7 0.1 3.5 2 1 0 3 3 3 2 KaiC AAA_24 PF13479.6 EDO19051.1 - 5.2e-06 26.3 0.1 0.088 12.5 0.0 3.2 3 1 0 3 3 3 2 AAA domain AAA_18 PF13238.6 EDO19051.1 - 6.2e-06 26.8 0.0 0.21 12.1 0.0 2.9 2 0 0 2 2 2 2 AAA domain AAA_7 PF12775.7 EDO19051.1 - 7.6e-06 25.5 0.1 0.069 12.6 0.0 2.7 2 1 0 2 2 2 2 P-loop containing dynein motor region ABC_tran PF00005.27 EDO19051.1 - 7.9e-06 26.4 0.0 0.056 14.0 0.0 3.9 3 1 0 3 3 3 1 ABC transporter Sigma54_activat PF00158.26 EDO19051.1 - 1.8e-05 24.5 0.1 0.21 11.3 0.0 3.4 3 1 0 3 3 2 2 Sigma-54 interaction domain AAA_25 PF13481.6 EDO19051.1 - 2.8e-05 23.8 5.1 0.12 12.0 0.4 4.1 2 2 1 3 3 3 1 AAA domain Parvo_NS1 PF01057.17 EDO19051.1 - 3.2e-05 23.2 0.1 0.13 11.3 0.0 2.3 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 PhoH PF02562.16 EDO19051.1 - 5.4e-05 22.8 0.5 0.19 11.2 0.1 2.4 2 0 0 2 2 2 2 PhoH-like protein AAA_28 PF13521.6 EDO19051.1 - 6.1e-05 23.3 0.0 0.56 10.4 0.0 2.6 2 0 0 2 2 2 2 AAA domain Bac_DnaA PF00308.18 EDO19051.1 - 8.5e-05 22.5 0.0 0.3 10.9 0.0 3.2 3 0 0 3 3 3 1 Bacterial dnaA protein AAA_11 PF13086.6 EDO19051.1 - 9.2e-05 22.3 0.7 0.99 9.1 0.0 3.1 3 0 0 3 3 3 2 AAA domain AAA_3 PF07726.11 EDO19051.1 - 0.00016 21.5 0.0 0.75 9.7 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) DUF815 PF05673.13 EDO19051.1 - 0.00019 20.7 0.0 0.19 10.9 0.0 2.7 2 0 0 2 2 2 2 Protein of unknown function (DUF815) AAA_17 PF13207.6 EDO19051.1 - 0.00021 21.7 1.4 0.56 10.6 0.0 3.4 4 0 0 4 4 2 2 AAA domain TsaE PF02367.17 EDO19051.1 - 0.00033 20.7 0.0 0.63 10.0 0.0 2.4 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE ResIII PF04851.15 EDO19051.1 - 0.00052 20.1 0.0 0.15 12.0 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DUF2075 PF09848.9 EDO19051.1 - 0.00066 19.0 0.0 1 8.5 0.0 2.4 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2075) ATPase_2 PF01637.18 EDO19051.1 - 0.0013 18.7 0.2 2.8 7.8 0.0 3.8 2 1 0 2 2 2 1 ATPase domain predominantly from Archaea AAA_30 PF13604.6 EDO19051.1 - 0.0013 18.4 0.2 2.2 8.0 0.0 2.6 2 0 0 2 2 2 2 AAA domain NACHT PF05729.12 EDO19051.1 - 0.0015 18.5 0.1 2.2 8.2 0.0 3.2 3 0 0 3 3 3 1 NACHT domain AAA_19 PF13245.6 EDO19051.1 - 0.003 17.9 0.5 3.1 8.1 0.0 3.2 2 1 1 3 3 2 1 AAA domain Sigma54_activ_2 PF14532.6 EDO19051.1 - 0.014 15.5 0.0 1.9 8.6 0.0 2.6 2 0 0 2 2 2 0 Sigma-54 interaction domain IPT PF01745.16 EDO19051.1 - 0.017 14.5 0.1 2.2 7.6 0.0 2.3 2 0 0 2 2 2 0 Isopentenyl transferase Zeta_toxin PF06414.12 EDO19051.1 - 0.019 14.3 0.0 6.6 6.0 0.0 2.8 2 0 0 2 2 2 0 Zeta toxin eIF-1a PF01176.19 EDO19051.1 - 0.024 14.5 1.1 0.2 11.5 0.4 2.6 1 1 1 2 2 2 0 Translation initiation factor 1A / IF-1 NB-ARC PF00931.22 EDO19051.1 - 0.029 13.5 0.0 4.9 6.2 0.0 2.3 2 0 0 2 2 2 0 NB-ARC domain UFD1 PF03152.14 EDO19051.1 - 0.034 13.6 0.0 0.12 11.9 0.0 1.8 1 1 1 2 2 2 0 Ubiquitin fusion degradation protein UFD1 Zot PF05707.12 EDO19051.1 - 0.045 13.4 0.0 2.7 7.6 0.0 3.1 2 1 0 2 2 2 0 Zonular occludens toxin (Zot) KAP_NTPase PF07693.14 EDO19051.1 - 0.048 12.9 0.2 2.1 7.5 0.0 2.8 2 2 1 3 3 3 0 KAP family P-loop domain Cytidylate_kin PF02224.18 EDO19051.1 - 0.054 13.2 0.0 7.8 6.2 0.0 2.7 2 0 0 2 2 2 0 Cytidylate kinase NTPase_1 PF03266.15 EDO19051.1 - 0.082 12.8 3.8 7.4 6.5 0.0 4.5 5 0 0 5 5 5 0 NTPase AAA_6 PF12774.7 EDO19051.1 - 0.12 11.3 0.4 5.5 5.8 0.0 2.5 3 0 0 3 3 2 0 Hydrolytic ATP binding site of dynein motor region Arf PF00025.21 EDO19052.1 - 3.4e-78 261.1 0.0 3.9e-78 260.9 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EDO19052.1 - 1.4e-14 54.3 0.1 1.9e-14 53.9 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EDO19052.1 - 3.5e-14 52.7 0.0 3.7e-14 52.6 0.0 1.1 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 EDO19052.1 - 7.4e-14 51.6 0.0 8.9e-14 51.3 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 EDO19052.1 - 5.5e-12 45.5 1.0 4.1e-08 32.8 0.2 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.12 EDO19052.1 - 1.4e-09 37.7 0.0 1.7e-09 37.4 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EDO19052.1 - 1.9e-05 24.7 0.0 3e-05 24.1 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRP54 PF00448.22 EDO19052.1 - 0.0081 15.8 0.2 0.015 14.9 0.2 1.4 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain ABC_tran PF00005.27 EDO19052.1 - 0.039 14.5 0.1 0.072 13.6 0.1 1.5 1 1 0 1 1 1 0 ABC transporter AAA_33 PF13671.6 EDO19052.1 - 0.041 14.1 0.6 0.1 12.8 0.6 1.9 1 1 0 1 1 1 0 AAA domain 6PF2K PF01591.18 EDO19052.1 - 0.051 12.9 0.2 0.074 12.3 0.1 1.5 1 1 0 1 1 1 0 6-phosphofructo-2-kinase cobW PF02492.19 EDO19052.1 - 0.053 13.1 0.1 7.5 6.1 0.2 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain GTP_EFTU PF00009.27 EDO19052.1 - 0.056 13.0 0.1 0.16 11.5 0.0 1.6 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EDO19052.1 - 0.061 13.2 0.1 8.9 6.2 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase AAA_18 PF13238.6 EDO19052.1 - 0.09 13.3 0.1 0.14 12.7 0.1 1.4 1 1 0 1 1 1 0 AAA domain NACHT PF05729.12 EDO19052.1 - 0.15 12.0 0.4 14 5.6 0.0 2.1 2 0 0 2 2 2 0 NACHT domain DUF5099 PF17025.5 EDO19053.1 - 0.092 13.2 0.0 0.2 12.1 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF5099) RNase_H2_suC PF08615.11 EDO19054.1 - 1.3e-16 61.0 0.0 1.6e-16 60.8 0.0 1.1 1 0 0 1 1 1 1 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) NCE101 PF11654.8 EDO19055.1 - 5.5e-20 70.8 0.1 6.3e-20 70.6 0.1 1.0 1 0 0 1 1 1 1 Non-classical export protein 1 DUF3730 PF12530.8 EDO19056.1 - 0.00088 18.9 0.3 0.015 14.9 0.0 2.9 2 0 0 2 2 2 1 Protein of unknown function (DUF3730) CTD_bind PF04818.13 EDO19056.1 - 0.014 16.2 4.7 0.02 15.7 0.6 3.5 3 0 0 3 3 3 0 RNA polymerase II-binding domain. Endonuclease_NS PF01223.23 EDO19057.1 - 3.6e-53 180.7 0.0 4.5e-53 180.4 0.0 1.1 1 0 0 1 1 1 1 DNA/RNA non-specific endonuclease DUF1414 PF07208.11 EDO19058.1 - 0.15 12.1 0.3 15 5.6 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1414) Utp13 PF08625.11 EDO19059.1 - 0.11 12.4 0.0 0.11 12.4 0.0 3.6 3 2 1 4 4 4 0 Utp13 specific WD40 associated domain Pex2_Pex12 PF04757.14 EDO19060.1 - 2.4e-18 66.6 15.7 3.6e-18 66.0 15.7 1.2 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region Mito_carr PF00153.27 EDO19061.1 - 7.9e-56 186.0 0.1 3.8e-19 68.4 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein SUI1 PF01253.22 EDO19062.1 - 8.3e-27 93.5 0.8 1.1e-26 93.1 0.8 1.2 1 0 0 1 1 1 1 Translation initiation factor SUI1 Bromo_TP_like PF17027.5 EDO19062.1 - 0.041 14.0 0.2 0.14 12.3 0.0 1.8 2 0 0 2 2 2 0 Histone-fold protein Cir_N PF10197.9 EDO19063.1 - 1.1e-10 41.4 8.7 2.4e-10 40.4 8.7 1.6 1 0 0 1 1 1 1 N-terminal domain of CBF1 interacting co-repressor CIR CWC25 PF12542.8 EDO19063.1 - 1.3e-07 32.5 3.0 1.3e-07 32.5 3.0 2.1 1 1 1 2 2 2 1 Pre-mRNA splicing factor NAP PF00956.18 EDO19064.1 - 4.1e-09 36.0 13.0 1.3e-08 34.4 13.0 1.7 1 1 0 1 1 1 1 Nucleosome assembly protein (NAP) Vpu PF00558.19 EDO19064.1 - 2.5 7.9 8.5 3.8 7.3 0.1 2.5 2 0 0 2 2 2 0 Vpu protein tRNA-synt_1e PF01406.19 EDO19065.1 - 3.6e-142 473.1 4.7 3.6e-142 473.1 4.7 1.9 2 1 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.11 EDO19065.1 - 2.2e-05 23.4 0.2 2.2e-05 23.4 0.2 3.0 3 0 0 3 3 3 2 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 EDO19065.1 - 0.00033 19.1 0.0 0.00033 19.1 0.0 2.1 2 0 0 2 2 2 1 tRNA synthetases class I (I, L, M and V) tRNA-synt_1c PF00749.21 EDO19065.1 - 0.044 12.7 0.0 0.044 12.7 0.0 2.4 2 0 0 2 2 2 0 tRNA synthetases class I (E and Q), catalytic domain LCAT PF02450.15 EDO19066.1 - 1.7e-10 40.6 0.0 2.9e-10 39.9 0.0 1.3 1 0 0 1 1 1 1 Lecithin:cholesterol acyltransferase PGAP1 PF07819.13 EDO19066.1 - 1e-06 28.7 0.0 2.7e-06 27.3 0.0 1.7 1 0 0 1 1 1 1 PGAP1-like protein Hydrolase_4 PF12146.8 EDO19066.1 - 4e-05 23.0 0.0 6.6e-05 22.3 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 DUF900 PF05990.12 EDO19066.1 - 0.00017 21.2 0.0 0.00049 19.7 0.0 1.7 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF900) Abhydrolase_6 PF12697.7 EDO19066.1 - 0.00054 20.6 0.0 0.00096 19.8 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.7 EDO19066.1 - 0.0013 18.6 0.0 0.0027 17.5 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EDO19066.1 - 0.0024 17.6 0.0 0.0042 16.8 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Ser_hydrolase PF06821.13 EDO19066.1 - 0.013 15.3 0.0 0.023 14.6 0.0 1.3 1 0 0 1 1 1 0 Serine hydrolase Palm_thioest PF02089.15 EDO19066.1 - 0.023 14.5 0.0 0.043 13.6 0.0 1.4 1 0 0 1 1 1 0 Palmitoyl protein thioesterase Abhydrolase_8 PF06259.12 EDO19066.1 - 0.042 13.5 0.0 0.09 12.4 0.0 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase zf-CSL PF05207.13 EDO19067.1 - 2.8e-18 65.4 0.6 4.4e-18 64.8 0.6 1.3 1 0 0 1 1 1 1 CSL zinc finger DnaJ PF00226.31 EDO19067.1 - 8.9e-14 51.4 0.1 1.5e-13 50.7 0.1 1.4 1 0 0 1 1 1 1 DnaJ domain zinc_ribbon_4 PF13717.6 EDO19067.1 - 0.098 12.6 0.4 11 6.0 0.0 2.4 2 0 0 2 2 2 0 zinc-ribbon domain RNA_pol_I_A49 PF06870.12 EDO19068.1 - 5.9e-125 417.1 0.1 6.8e-125 416.9 0.1 1.0 1 0 0 1 1 1 1 A49-like RNA polymerase I associated factor AAA_23 PF13476.6 EDO19069.1 - 7.6e-37 127.8 2.9 7.6e-37 127.8 2.9 8.1 3 2 5 8 8 4 1 AAA domain Rad50_zn_hook PF04423.14 EDO19069.1 - 2.6e-17 62.4 1.2 2.6e-17 62.4 1.2 8.1 8 0 0 8 8 8 1 Rad50 zinc hook motif AAA_21 PF13304.6 EDO19069.1 - 3.4e-10 40.2 3.9 8e-07 29.2 0.9 4.9 5 1 1 6 6 6 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 EDO19069.1 - 1e-07 32.1 29.3 1e-07 32.1 29.3 6.2 1 1 2 3 3 2 1 AAA ATPase domain SMC_N PF02463.19 EDO19069.1 - 1.7e-07 30.9 0.1 1.7e-07 30.9 0.1 3.6 2 1 0 2 2 1 1 RecF/RecN/SMC N terminal domain SbcCD_C PF13558.6 EDO19069.1 - 2.7e-06 27.5 0.0 8e-06 26.0 0.0 1.8 1 0 0 1 1 1 1 Putative exonuclease SbcCD, C subunit AAA_29 PF13555.6 EDO19069.1 - 0.00035 20.2 0.0 0.0011 18.7 0.0 1.8 1 0 0 1 1 1 1 P-loop containing region of AAA domain ADIP PF11559.8 EDO19069.1 - 0.0022 18.1 4.5 0.0022 18.1 4.5 11.0 6 4 5 11 11 9 1 Afadin- and alpha -actinin-Binding MscS_porin PF12795.7 EDO19069.1 - 0.0044 16.6 0.7 0.0044 16.6 0.7 8.6 2 2 5 8 8 6 2 Mechanosensitive ion channel porin domain TPR_MLP1_2 PF07926.12 EDO19069.1 - 0.0069 16.5 5.8 0.0069 16.5 5.8 10.5 3 3 5 9 9 9 1 TPR/MLP1/MLP2-like protein AAA_13 PF13166.6 EDO19069.1 - 0.0096 14.6 131.0 0.0098 14.6 0.0 7.6 3 1 3 7 7 7 3 AAA domain Occludin_ELL PF07303.13 EDO19069.1 - 0.095 13.4 0.2 0.095 13.4 0.2 10.5 5 3 5 10 10 9 0 Occludin homology domain AAA_16 PF13191.6 EDO19069.1 - 0.16 12.4 0.0 0.16 12.4 0.0 3.2 3 1 0 3 3 2 0 AAA ATPase domain DDE_Tnp_1 PF01609.21 EDO19069.1 - 4.6 6.8 9.4 0.87 9.2 3.3 2.6 2 0 0 2 2 2 0 Transposase DDE domain RT_RNaseH PF17917.1 EDO19070.1 - 1.7e-17 63.6 0.0 5.4e-17 62.0 0.0 1.9 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 EDO19070.1 - 6e-16 58.3 0.0 1.5e-15 57.0 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 EDO19070.1 - 1.1e-14 54.7 0.0 2.8e-14 53.3 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain MLVIN_C PF18697.1 EDO19070.1 - 0.0051 16.9 0.2 0.023 14.8 0.1 2.1 2 0 0 2 2 2 1 Murine leukemia virus (MLV) integrase (IN) C-terminal domain Minor_capsid_2 PF11114.8 EDO19070.1 - 0.042 13.9 0.1 0.11 12.5 0.1 1.8 1 1 1 2 2 2 0 Minor capsid protein Integrase_Zn PF02022.19 EDO19070.1 - 2.4 8.2 5.7 5.1 7.1 0.5 2.5 2 0 0 2 2 2 0 Integrase Zinc binding domain DUF3811 PF11656.8 EDO19070.1 - 5 7.6 6.9 9.6 6.7 4.4 2.6 2 1 1 3 3 3 0 YjbD family (DUF3811) Dynamitin PF04912.14 EDO19071.1 - 0.031 13.6 11.6 0.051 12.9 11.6 1.2 1 0 0 1 1 1 0 Dynamitin DUF484 PF04340.12 EDO19071.1 - 0.041 13.6 2.6 0.067 12.9 2.6 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF484 XhlA PF10779.9 EDO19071.1 - 0.1 12.8 17.5 0.16 12.2 0.2 3.4 2 1 2 4 4 4 0 Haemolysin XhlA Glyco_transf_8C PF08437.10 EDO19071.1 - 0.18 11.9 0.0 0.92 9.6 0.0 2.2 2 0 0 2 2 2 0 Glycosyl transferase family 8 C-terminal SecD-TM1 PF13721.6 EDO19071.1 - 4.1 7.9 4.7 7.7 7.0 0.5 2.5 1 1 1 2 2 2 0 SecD export protein N-terminal TM region RRM_1 PF00076.22 EDO19072.1 - 1.2e-05 25.0 0.0 2.4e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CTD_bind PF04818.13 EDO19072.1 - 0.00041 21.1 0.0 0.0011 19.7 0.0 1.8 1 0 0 1 1 1 1 RNA polymerase II-binding domain. RRM_7 PF16367.5 EDO19072.1 - 0.0083 16.2 0.0 0.033 14.3 0.0 2.0 2 0 0 2 2 2 1 RNA recognition motif CTK3 PF12243.8 EDO19072.1 - 0.11 12.5 0.0 0.3 11.1 0.0 1.8 1 0 0 1 1 1 0 CTD kinase subunit gamma CTK3 Hepatitis_core PF00906.20 EDO19072.1 - 1.1 8.8 11.8 4.8 6.7 11.7 2.1 2 0 0 2 2 2 0 Hepatitis core antigen MRP-L46 PF11788.8 EDO19073.1 - 2.8e-39 134.5 0.0 4.4e-39 133.9 0.0 1.3 1 0 0 1 1 1 1 39S mitochondrial ribosomal protein L46 ANAPC4_WD40 PF12894.7 EDO19074.1 - 2.1e-16 60.0 0.5 0.0022 18.2 0.1 5.9 1 1 5 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EDO19074.1 - 2.3e-11 44.1 10.4 5.7e-05 23.8 0.0 6.5 7 0 0 7 7 7 4 WD domain, G-beta repeat Cytochrom_D1 PF02239.16 EDO19074.1 - 0.0043 15.6 0.1 0.42 9.1 0.1 2.8 3 0 0 3 3 3 2 Cytochrome D1 heme domain Ge1_WD40 PF16529.5 EDO19074.1 - 0.009 15.0 0.9 0.15 10.9 0.0 2.6 2 1 0 2 2 2 1 WD40 region of Ge1, enhancer of mRNA-decapping protein RTC4 PF14474.6 EDO19075.1 - 1.3e-33 115.7 0.0 3.1e-33 114.5 0.0 1.6 1 0 0 1 1 1 1 RTC4-like domain DUF5582 PF17819.1 EDO19075.1 - 0.21 12.0 0.1 0.21 12.0 0.1 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF5582) zf-CCHC PF00098.23 EDO19076.1 - 2.1e-52 173.0 55.1 7e-09 35.4 1.8 7.1 7 0 0 7 7 7 7 Zinc knuckle zf-CCHC_4 PF14392.6 EDO19076.1 - 3.3e-16 58.7 41.3 0.0065 16.2 0.8 7.1 6 1 1 7 7 7 7 Zinc knuckle zf-CCHC_3 PF13917.6 EDO19076.1 - 1.5e-06 28.1 50.8 0.18 11.8 1.4 7.1 2 2 5 7 7 7 6 Zinc knuckle zf-CCHC_5 PF14787.6 EDO19076.1 - 0.00014 21.5 35.9 2.5 7.9 0.3 7.1 4 3 3 7 7 7 7 GAG-polyprotein viral zinc-finger zf-CCHC_6 PF15288.6 EDO19076.1 - 0.039 13.8 2.0 0.039 13.8 2.0 6.8 7 0 0 7 7 7 0 Zinc knuckle zf-CCHC_2 PF13696.6 EDO19076.1 - 0.068 13.0 1.1 0.068 13.0 1.1 7.0 7 0 0 7 7 7 0 Zinc knuckle zf-C2H2_10 PF16588.5 EDO19076.1 - 1.4 8.7 40.4 0.38 10.5 0.4 6.4 6 0 0 6 6 6 0 C2H2 zinc-finger TRAF6_Z2 PF18048.1 EDO19076.1 - 6.9 6.9 16.9 50 4.1 0.2 5.3 4 2 0 4 4 4 0 TNF receptor-associated factor 6 zinc finger 2 Pterin_bind PF00809.22 EDO19077.1 - 4.5e-55 187.0 0.0 9.2e-55 186.0 0.0 1.5 1 0 0 1 1 1 1 Pterin binding enzyme FolB PF02152.18 EDO19077.1 - 4.2e-41 140.0 0.1 1.1e-21 77.4 0.5 2.6 2 0 0 2 2 2 2 Dihydroneopterin aldolase HPPK PF01288.20 EDO19077.1 - 7e-34 116.7 0.0 1.7e-33 115.4 0.0 1.7 1 0 0 1 1 1 1 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) FAD_binding_3 PF01494.19 EDO19078.1 - 2.4e-18 66.5 1.6 2.2e-12 46.9 0.0 3.1 2 1 0 2 2 2 2 FAD binding domain Lycopene_cycl PF05834.12 EDO19078.1 - 7.5e-05 21.9 0.1 0.0043 16.2 0.3 2.6 3 0 0 3 3 3 1 Lycopene cyclase protein Pyr_redox_2 PF07992.14 EDO19078.1 - 0.0023 17.2 0.1 0.013 14.8 0.1 1.8 1 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EDO19078.1 - 0.0097 15.2 0.1 0.018 14.3 0.1 1.4 1 0 0 1 1 1 1 Thi4 family NAD_binding_8 PF13450.6 EDO19078.1 - 0.023 14.9 0.2 0.049 13.9 0.2 1.5 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain SE PF08491.10 EDO19078.1 - 0.031 13.3 0.0 0.049 12.7 0.0 1.2 1 0 0 1 1 1 0 Squalene epoxidase FAD_binding_2 PF00890.24 EDO19078.1 - 0.042 12.9 0.8 0.062 12.4 0.8 1.2 1 0 0 1 1 1 0 FAD binding domain Pyr_redox_3 PF13738.6 EDO19078.1 - 0.06 12.6 0.0 0.14 11.4 0.0 1.6 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 EDO19078.1 - 0.14 11.0 0.1 1.1 8.1 0.2 2.1 2 0 0 2 2 2 0 Tryptophan halogenase DAO PF01266.24 EDO19078.1 - 0.16 11.5 0.3 0.31 10.6 0.3 1.4 1 0 0 1 1 1 0 FAD dependent oxidoreductase FAD_oxidored PF12831.7 EDO19078.1 - 0.17 11.2 0.6 0.27 10.5 0.6 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase HI0933_like PF03486.14 EDO19078.1 - 0.18 10.5 0.4 0.25 10.0 0.4 1.2 1 0 0 1 1 1 0 HI0933-like protein RRM_1 PF00076.22 EDO19079.1 - 9.1e-15 54.2 0.0 3e-14 52.6 0.0 1.9 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Pro_isomerase PF00160.21 EDO19079.1 - 4.4e-09 36.8 0.0 6.4e-09 36.3 0.0 1.2 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD DUF676 PF05057.14 EDO19080.1 - 8.1e-07 28.8 0.2 1.7e-06 27.7 0.0 1.6 2 0 0 2 2 2 1 Putative serine esterase (DUF676) Palm_thioest PF02089.15 EDO19080.1 - 1.5e-06 28.3 0.0 4.9e-06 26.6 0.0 1.8 1 1 0 1 1 1 1 Palmitoyl protein thioesterase PGAP1 PF07819.13 EDO19080.1 - 0.00048 19.9 0.0 0.0013 18.5 0.0 1.7 1 1 0 1 1 1 1 PGAP1-like protein Abhydrolase_1 PF00561.20 EDO19080.1 - 0.00051 19.8 0.0 0.0075 15.9 0.0 2.3 2 1 0 2 2 2 1 alpha/beta hydrolase fold DUF915 PF06028.11 EDO19080.1 - 0.0015 17.9 0.0 0.0092 15.3 0.0 2.2 3 0 0 3 3 3 1 Alpha/beta hydrolase of unknown function (DUF915) DUF3989 PF13150.6 EDO19080.1 - 0.015 15.0 0.0 0.031 14.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3989) Peripla_BP_4 PF13407.6 EDO19080.1 - 0.14 11.7 0.0 0.33 10.5 0.0 1.5 2 0 0 2 2 2 0 Periplasmic binding protein domain DUF5314 PF17241.2 EDO19081.1 - 2.3e-49 167.7 0.3 2.8e-49 167.5 0.3 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5314) KH_dom-like PF14714.6 EDO19081.1 - 0.028 14.7 0.0 0.046 14.0 0.0 1.4 1 0 0 1 1 1 0 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal PTB PF08416.13 EDO19081.1 - 0.14 12.4 0.2 0.32 11.2 0.0 1.7 2 0 0 2 2 2 0 Phosphotyrosine-binding domain Dsl1_N PF11988.8 EDO19082.1 - 6.6e-128 426.6 29.2 6.6e-128 426.6 29.2 1.6 2 0 0 2 2 2 1 Retrograde transport protein Dsl1 N terminal Dsl1_C PF11989.8 EDO19082.1 - 1.2e-93 312.2 9.8 1.2e-93 312.2 9.8 2.6 2 0 0 2 2 2 1 Retrograde transport protein Dsl1 C terminal DUF771 PF05595.11 EDO19082.1 - 0.6 10.1 6.8 6.1 6.9 0.1 4.1 4 0 0 4 4 4 0 Domain of unknown function (DUF771) HMA PF00403.26 EDO19083.1 - 1.1e-10 41.8 0.2 1.3e-10 41.6 0.2 1.1 1 0 0 1 1 1 1 Heavy-metal-associated domain Yae1_N PF09811.9 EDO19084.1 - 2.8e-14 52.5 3.4 2.8e-14 52.5 3.4 1.5 2 0 0 2 2 2 1 Essential protein Yae1, N terminal GYF PF02213.16 EDO19085.1 - 4.3e-08 32.7 2.1 8.1e-08 31.8 2.1 1.5 1 0 0 1 1 1 1 GYF domain ORC5_C PF14630.6 EDO19086.1 - 3.8e-61 207.1 0.1 4.9e-61 206.7 0.1 1.1 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 5 C-terminus AAA_16 PF13191.6 EDO19086.1 - 3.2e-09 37.4 0.0 5.7e-09 36.6 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EDO19086.1 - 9.2e-09 35.7 0.0 1.9e-08 34.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain ResIII PF04851.15 EDO19086.1 - 1.5e-05 25.1 0.0 0.00012 22.1 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit CRAL_TRIO_2 PF13716.6 EDO19086.1 - 0.00012 22.2 0.7 0.00065 19.9 0.1 2.2 2 0 0 2 2 2 1 Divergent CRAL/TRIO domain TniB PF05621.11 EDO19086.1 - 0.0061 16.0 0.0 0.012 15.0 0.0 1.5 1 1 0 1 1 1 1 Bacterial TniB protein NB-ARC PF00931.22 EDO19086.1 - 0.0098 15.1 0.0 0.016 14.4 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain KAP_NTPase PF07693.14 EDO19086.1 - 0.012 14.8 1.9 1.6 7.9 0.5 2.4 1 1 1 2 2 2 0 KAP family P-loop domain AAA_14 PF13173.6 EDO19086.1 - 0.032 14.2 1.3 0.37 10.8 1.3 2.4 1 1 0 1 1 1 0 AAA domain AAA_24 PF13479.6 EDO19086.1 - 0.035 13.8 0.1 0.26 11.0 0.0 2.3 2 0 0 2 2 2 0 AAA domain Microtub_bd PF16796.5 EDO19086.1 - 0.051 13.5 0.0 1 9.3 0.0 2.6 2 0 0 2 2 2 0 Microtubule binding AAA_7 PF12775.7 EDO19086.1 - 0.058 12.9 0.0 0.13 11.8 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region NACHT PF05729.12 EDO19086.1 - 0.16 11.9 5.9 1.5 8.7 5.9 2.2 1 1 0 1 1 1 0 NACHT domain CCER1 PF15482.6 EDO19086.1 - 0.21 11.5 0.0 0.36 10.7 0.0 1.3 1 0 0 1 1 1 0 Coiled-coil domain-containing glutamate-rich protein family 1 DUF1744 PF08490.12 EDO19087.1 - 9.6e-139 462.4 8.1 1.5e-138 461.7 8.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1744) DNA_pol_B_exo1 PF03104.19 EDO19087.1 - 2.1e-78 263.8 4.0 2.1e-78 263.8 4.0 2.7 2 1 0 2 2 2 1 DNA polymerase family B, exonuclease domain DNA_pol_B PF00136.21 EDO19087.1 - 6.5e-18 64.7 6.3 2.8e-14 52.7 1.5 4.1 3 1 0 3 3 3 2 DNA polymerase family B DNA_pol_B_exo2 PF10108.9 EDO19087.1 - 1.6e-06 27.9 1.2 1.4e-05 24.9 1.2 2.4 1 1 0 1 1 1 1 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB RNase_H_2 PF13482.6 EDO19087.1 - 0.00031 20.8 1.6 0.0012 18.9 0.0 2.9 3 0 0 3 3 3 1 RNase_H superfamily zf-CHY PF05495.12 EDO19087.1 - 0.17 12.4 11.0 0.55 10.7 11.0 1.9 1 0 0 1 1 1 0 CHY zinc finger TRAF6_Z2 PF18048.1 EDO19087.1 - 0.39 10.8 1.1 1 9.5 1.1 1.7 1 0 0 1 1 1 0 TNF receptor-associated factor 6 zinc finger 2 zf_UBZ PF18439.1 EDO19087.1 - 3.2 7.4 4.7 1.1 8.9 0.2 2.5 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger YIF1 PF03878.15 EDO19088.1 - 2.3e-78 263.0 10.5 2.3e-78 263.0 10.5 1.3 2 0 0 2 2 2 1 YIF1 Yip1 PF04893.17 EDO19088.1 - 0.15 11.8 13.4 0.1 12.3 11.2 1.9 1 1 1 2 2 2 0 Yip1 domain DnaJ PF00226.31 EDO19089.1 - 4.2e-16 58.8 0.2 1.2e-15 57.3 0.2 1.9 1 0 0 1 1 1 1 DnaJ domain Fur_reg_FbpA PF13076.6 EDO19089.1 - 0.0096 15.6 0.9 0.2 11.4 0.0 2.8 2 0 0 2 2 2 1 Fur-regulated basic protein A KaiA PF07688.12 EDO19089.1 - 1.5 8.9 6.0 0.99 9.6 0.1 3.1 2 2 2 4 4 4 0 KaiA C-terminal domain CRAL_TRIO PF00650.20 EDO19090.1 - 4.6e-41 140.2 0.0 6.8e-41 139.6 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 EDO19090.1 - 3.2e-16 59.2 2.5 6.5e-16 58.3 2.5 1.5 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.6 EDO19090.1 - 0.099 12.8 0.0 0.17 12.0 0.0 1.4 1 0 0 1 1 1 0 Divergent CRAL/TRIO domain SPRY PF00622.28 EDO19090.1 - 0.12 12.5 0.0 0.18 11.9 0.0 1.3 1 0 0 1 1 1 0 SPRY domain ArAE_2_N PF10337.9 EDO19091.1 - 6.4e-55 187.0 0.6 6.4e-55 187.0 0.6 3.6 2 2 1 3 3 3 1 Putative ER transporter, 6TM, N-terminal FUSC_2 PF13515.6 EDO19091.1 - 1.1e-14 54.6 13.2 1.1e-14 54.6 13.2 2.6 2 1 0 2 2 2 1 Fusaric acid resistance protein-like ALMT PF11744.8 EDO19091.1 - 1.9e-05 23.7 7.5 3.6e-05 22.8 4.1 2.2 2 0 0 2 2 2 1 Aluminium activated malate transporter ArAE_2 PF10334.9 EDO19091.1 - 0.00022 21.1 0.0 0.00041 20.2 0.0 1.3 1 0 0 1 1 1 1 Aromatic acid exporter family member 2 UFD1 PF03152.14 EDO19092.1 - 6.6e-69 230.8 0.0 8.7e-69 230.4 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 DUF1232 PF06803.12 EDO19092.1 - 0.074 12.9 0.0 0.12 12.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1232) TPR_17 PF13431.6 EDO19093.1 - 4.1e-13 48.7 8.4 0.026 14.9 0.0 6.8 8 0 0 8 8 7 3 Tetratricopeptide repeat TPR_2 PF07719.17 EDO19093.1 - 4.8e-13 48.1 19.4 2.8 8.3 0.1 10.2 10 0 0 10 10 10 3 Tetratricopeptide repeat TPR_16 PF13432.6 EDO19093.1 - 3.8e-09 37.0 4.2 0.0034 18.0 0.0 6.4 6 1 0 6 6 6 1 Tetratricopeptide repeat TPR_1 PF00515.28 EDO19093.1 - 3.9e-09 35.9 20.4 0.58 10.1 0.1 8.8 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_19 PF14559.6 EDO19093.1 - 3.9e-08 33.7 8.8 0.0047 17.4 0.0 6.1 6 1 1 7 7 7 2 Tetratricopeptide repeat TPR_12 PF13424.6 EDO19093.1 - 5.1e-08 33.1 12.8 0.21 11.9 0.0 6.4 6 1 1 7 7 7 3 Tetratricopeptide repeat TPR_9 PF13371.6 EDO19093.1 - 1e-07 31.9 0.1 0.029 14.5 0.1 5.2 3 1 2 5 5 5 3 Tetratricopeptide repeat TPR_11 PF13414.6 EDO19093.1 - 6.4e-07 28.9 12.0 0.079 12.7 0.0 5.2 4 1 2 6 6 6 3 TPR repeat TPR_6 PF13174.6 EDO19093.1 - 2.6e-06 27.7 8.7 0.94 10.3 0.0 7.1 8 0 0 8 8 7 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EDO19093.1 - 7.3e-06 26.1 4.5 0.067 13.4 0.1 4.8 3 2 1 5 5 5 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.6 EDO19093.1 - 1.2e-05 25.7 7.3 3 8.9 0.0 7.3 6 2 3 9 9 8 1 Tetratricopeptide repeat TPR_20 PF14561.6 EDO19093.1 - 1.3e-05 25.5 0.0 1.6 9.1 0.0 4.8 3 2 2 5 5 5 2 Tetratricopeptide repeat TPR_8 PF13181.6 EDO19093.1 - 1.3e-05 25.0 19.7 0.51 10.7 0.0 8.3 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_15 PF13429.6 EDO19093.1 - 0.00017 20.9 1.4 1.6 7.9 0.0 3.7 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_10 PF13374.6 EDO19093.1 - 0.0004 20.2 9.7 0.00062 19.6 0.2 4.8 5 0 0 5 5 5 1 Tetratricopeptide repeat Alkyl_sulf_dimr PF14863.6 EDO19093.1 - 0.024 15.1 0.0 5.5 7.5 0.0 3.1 2 0 0 2 2 2 0 Alkyl sulfatase dimerisation TPR_7 PF13176.6 EDO19093.1 - 0.059 13.4 11.4 52 4.2 0.1 6.2 6 0 0 6 6 6 0 Tetratricopeptide repeat DUF3273 PF11677.8 EDO19093.1 - 0.1 11.9 0.1 0.2 10.9 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3273) GAGA_bind PF06217.12 EDO19093.1 - 0.31 11.3 9.5 0.73 10.1 1.6 2.6 3 0 0 3 3 2 0 GAGA binding protein-like family ANAPC5 PF12862.7 EDO19093.1 - 0.91 9.6 6.3 2.8 8.1 0.0 3.6 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 5 PEX11 PF05648.14 EDO19093.1 - 4.3 6.7 8.4 2.6 7.4 0.2 3.5 3 0 0 3 3 3 0 Peroxisomal biogenesis factor 11 (PEX11) Ist1 PF03398.14 EDO19094.1 - 3.8e-57 192.8 1.5 5.2e-57 192.4 1.5 1.2 1 0 0 1 1 1 1 Regulator of Vps4 activity in the MVB pathway Complex1_51K PF01512.17 EDO19094.1 - 0.087 12.7 0.6 0.15 11.9 0.6 1.3 1 0 0 1 1 1 0 Respiratory-chain NADH dehydrogenase 51 Kd subunit HTH_psq PF05225.16 EDO19094.1 - 0.17 11.6 0.0 0.53 10.1 0.0 1.8 2 0 0 2 2 2 0 helix-turn-helix, Psq domain Tam41_Mmp37 PF09139.11 EDO19095.1 - 3.2e-92 309.4 8.6 4.5e-85 285.9 2.4 2.0 1 1 1 2 2 2 2 Phosphatidate cytidylyltransferase, mitochondrial PI3_PI4_kinase PF00454.27 EDO19096.1 - 4.7e-30 105.2 0.0 5.5e-29 101.7 0.0 2.5 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase Pik1 PF11522.8 EDO19096.1 - 1.8e-21 75.8 0.0 5.2e-21 74.3 0.0 1.9 1 0 0 1 1 1 1 Yeast phosphatidylinositol-4-OH kinase Pik1 PI3Ka PF00613.20 EDO19096.1 - 7e-07 28.8 1.0 1.8e-06 27.5 1.0 1.7 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) DUF4135 PF13575.6 EDO19096.1 - 0.079 12.3 0.0 0.14 11.4 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4135) AA_permease PF00324.21 EDO19097.1 - 1.1e-138 462.9 47.8 1.2e-138 462.7 47.8 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EDO19097.1 - 2.4e-32 112.3 52.5 3.3e-32 111.9 52.5 1.2 1 0 0 1 1 1 1 Amino acid permease RhodobacterPufX PF11511.8 EDO19097.1 - 0.0006 19.4 0.9 0.056 13.1 0.2 2.9 2 0 0 2 2 2 2 Intrinsic membrane protein PufX AA_permease PF00324.21 EDO19098.1 - 6.4e-139 463.6 51.6 7.3e-139 463.4 51.6 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EDO19098.1 - 5.6e-29 101.2 56.3 8e-29 100.7 56.3 1.2 1 0 0 1 1 1 1 Amino acid permease Sec2p PF06428.11 EDO19099.1 - 3.2e-26 91.1 11.5 3.2e-26 91.1 11.5 4.3 4 0 0 4 4 4 1 GDP/GTP exchange factor Sec2p TIMELESS PF04821.14 EDO19100.1 - 2.7e-91 305.7 7.8 2.7e-91 305.7 7.8 3.0 4 0 0 4 4 4 2 Timeless protein Peptidase_S8 PF00082.22 EDO19101.1 - 8.6e-13 48.2 8.5 2.3e-12 46.8 8.5 1.7 1 1 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 EDO19101.1 - 0.007 17.0 0.0 0.018 15.7 0.0 1.7 1 0 0 1 1 1 1 Peptidase inhibitor I9 Sad1_UNC PF07738.13 EDO19102.1 - 4.9e-32 110.7 0.1 1e-31 109.6 0.1 1.6 1 0 0 1 1 1 1 Sad1 / UNC-like C-terminal KRAP_IP3R_bind PF14722.6 EDO19102.1 - 0.003 17.3 2.6 0.01 15.6 0.0 2.8 2 1 1 3 3 3 1 Ki-ras-induced actin-interacting protein-IP3R-interacting domain F5_F8_type_C PF00754.25 EDO19102.1 - 0.017 15.3 0.1 0.064 13.4 0.0 2.0 2 0 0 2 2 2 0 F5/8 type C domain Peptidase_M1 PF01433.20 EDO19103.1 - 9.8e-06 25.3 0.0 5.1e-05 22.9 0.0 2.1 2 0 0 2 2 2 1 Peptidase family M1 domain Peptidase_M1_N PF17900.1 EDO19103.1 - 0.00078 19.7 4.0 0.24 11.6 0.1 3.4 1 1 2 3 3 3 2 Peptidase M1 N-terminal domain BUD22 PF09073.10 EDO19103.1 - 0.49 9.7 27.5 1.3 8.3 27.5 1.7 1 0 0 1 1 1 0 BUD22 2-Hacid_dh_C PF02826.19 EDO19104.1 - 1.4e-57 194.0 0.0 2.3e-57 193.2 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EDO19104.1 - 1.3e-14 54.0 0.0 1.8e-14 53.6 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 EDO19104.1 - 1.7e-06 28.3 0.0 3.9e-06 27.1 0.0 1.6 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase IlvN PF07991.12 EDO19104.1 - 5.5e-05 22.8 0.0 0.00018 21.1 0.0 1.9 2 0 0 2 2 2 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain Shikimate_DH PF01488.20 EDO19104.1 - 0.022 14.8 0.0 0.078 13.0 0.0 1.9 2 1 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase F420_oxidored PF03807.17 EDO19104.1 - 0.05 14.2 0.0 0.15 12.7 0.0 1.9 1 1 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent ThiF PF00899.21 EDO19104.1 - 0.15 11.4 0.2 0.69 9.2 0.1 2.0 2 0 0 2 2 2 0 ThiF family TMEM192 PF14802.6 EDO19105.1 - 0.041 13.0 0.3 0.054 12.6 0.3 1.2 1 0 0 1 1 1 0 TMEM192 family Per1 PF04080.13 EDO19106.1 - 3.5e-83 279.3 20.3 4.7e-83 278.9 20.3 1.1 1 0 0 1 1 1 1 Per1-like family HTH_23 PF13384.6 EDO19106.1 - 0.059 13.2 0.1 0.26 11.2 0.0 2.0 2 0 0 2 2 2 0 Homeodomain-like domain DUF3611 PF12263.8 EDO19106.1 - 0.17 11.7 2.9 0.5 10.2 0.5 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3611) Got1 PF04178.12 EDO19106.1 - 1.3 9.5 8.4 0.7 10.3 3.9 2.5 2 0 0 2 2 2 0 Got1/Sft2-like family Spindle_Spc25 PF08234.12 EDO19107.1 - 9.4e-18 64.2 0.4 3.5e-17 62.4 0.0 2.1 2 0 0 2 2 2 1 Chromosome segregation protein Spc25 Spc7 PF08317.11 EDO19107.1 - 6.3e-05 22.0 20.0 9.6e-05 21.4 20.0 1.2 1 0 0 1 1 1 1 Spc7 kinetochore protein DUF2316 PF10078.9 EDO19107.1 - 0.0093 16.2 3.2 0.0093 16.2 3.2 2.0 1 1 1 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2316) Lyase_1 PF00206.20 EDO19107.1 - 0.0098 15.3 5.2 0.014 14.8 5.2 1.2 1 0 0 1 1 1 1 Lyase APG6_N PF17675.1 EDO19107.1 - 0.024 15.2 7.3 0.024 15.2 7.3 2.3 1 1 1 2 2 2 0 Apg6 coiled-coil region T3SSipB PF16535.5 EDO19107.1 - 0.036 14.6 5.1 0.06 13.8 5.1 1.4 1 0 0 1 1 1 0 Type III cell invasion protein SipB AAA_13 PF13166.6 EDO19107.1 - 0.039 12.6 14.3 0.054 12.2 14.3 1.1 1 0 0 1 1 1 0 AAA domain Glyco_hydro_106 PF17132.4 EDO19107.1 - 0.069 11.4 2.2 0.086 11.1 2.2 1.2 1 0 0 1 1 1 0 alpha-L-rhamnosidase CENP-F_leu_zip PF10473.9 EDO19107.1 - 0.088 12.8 29.3 0.23 11.5 27.0 2.6 2 1 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 GAS PF13851.6 EDO19107.1 - 0.097 12.0 25.1 0.29 10.5 25.1 1.9 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding DUF3450 PF11932.8 EDO19107.1 - 0.14 11.5 15.5 0.26 10.6 15.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) V_ATPase_I PF01496.19 EDO19107.1 - 0.24 9.3 8.7 0.26 9.2 8.7 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family PI3K_P85_iSH2 PF16454.5 EDO19107.1 - 0.24 11.0 21.0 0.45 10.1 14.2 2.6 1 1 1 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain Zw10 PF06248.13 EDO19107.1 - 0.24 9.9 14.5 0.34 9.4 14.5 1.2 1 0 0 1 1 1 0 Centromere/kinetochore Zw10 Lipoprotein_7 PF01540.16 EDO19107.1 - 0.32 10.2 14.2 0.74 9.0 13.6 1.8 1 1 1 2 2 2 0 Adhesin lipoprotein Fmp27_WPPW PF10359.9 EDO19107.1 - 0.35 9.7 21.8 0.29 9.9 9.8 2.1 1 1 1 2 2 2 0 RNA pol II promoter Fmp27 protein domain Sec34 PF04136.15 EDO19107.1 - 0.45 10.4 14.5 0.22 11.4 11.7 1.9 2 1 0 2 2 2 0 Sec34-like family DUF4407 PF14362.6 EDO19107.1 - 0.79 9.0 8.8 1.1 8.5 8.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) TPR_MLP1_2 PF07926.12 EDO19107.1 - 0.81 9.8 22.9 0.4 10.7 1.7 2.8 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein DUF2009 PF09418.10 EDO19107.1 - 0.89 8.6 9.2 1.2 8.1 9.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2009) LMBR1 PF04791.16 EDO19107.1 - 0.91 8.3 9.1 1.1 8.1 9.1 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF745 PF05335.13 EDO19107.1 - 1.5 8.6 9.3 3.1 7.5 9.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF745) Csm1_N PF18504.1 EDO19107.1 - 1.7 9.0 21.1 1.3 9.5 8.2 2.8 1 1 1 2 2 2 0 Csm1 N-terminal domain Atg14 PF10186.9 EDO19107.1 - 2.1 7.4 19.8 3.8 6.5 19.8 1.7 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Nsp1_C PF05064.13 EDO19107.1 - 2.2 8.1 17.1 3.1 7.7 7.2 2.6 1 1 1 2 2 2 0 Nsp1-like C-terminal region Seryl_tRNA_N PF02403.22 EDO19107.1 - 2.3 8.5 18.1 2.4 8.5 16.4 1.9 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain ALMT PF11744.8 EDO19107.1 - 2.8 6.7 11.3 3.7 6.3 11.3 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter GBP_C PF02841.14 EDO19107.1 - 2.8 7.2 22.7 7.4 5.9 22.7 1.6 1 1 0 1 1 1 0 Guanylate-binding protein, C-terminal domain TMPIT PF07851.13 EDO19107.1 - 2.9 7.0 17.7 2.3 7.4 15.9 1.7 2 1 0 2 2 2 0 TMPIT-like protein ADIP PF11559.8 EDO19107.1 - 3.8 7.6 21.6 18 5.4 21.6 2.0 1 1 0 1 1 1 0 Afadin- and alpha -actinin-Binding DUF4467 PF14729.6 EDO19107.1 - 4.5 7.7 10.6 0.76 10.2 0.6 2.3 2 0 0 2 2 2 0 Domain of unknown function with cystatin-like fold (DUF4467) Synaptobrevin PF00957.21 EDO19107.1 - 5 7.0 12.4 0.18 11.6 4.0 2.3 1 1 1 2 2 2 0 Synaptobrevin Exonuc_VII_L PF02601.15 EDO19107.1 - 5.2 6.5 16.2 6.6 6.2 16.2 1.3 1 1 0 1 1 1 0 Exonuclease VII, large subunit DUF848 PF05852.11 EDO19107.1 - 6.3 6.9 17.3 20 5.3 7.3 2.6 1 1 1 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) TLE_N PF03920.15 EDO19107.1 - 8.2 6.5 17.1 1.3 9.1 1.8 3.1 1 1 1 2 2 2 0 Groucho/TLE N-terminal Q-rich domain Exo_endo_phos PF03372.23 EDO19108.1 - 1.8e-16 60.4 0.0 2.4e-16 60.0 0.0 1.1 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DUF4231 PF14015.6 EDO19108.1 - 0.0017 18.8 2.8 0.0042 17.5 2.8 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF4231) DUF2207 PF09972.9 EDO19108.1 - 0.13 11.0 0.3 0.18 10.5 0.3 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Glyco_transf_28 PF03033.20 EDO19109.1 - 9.1e-33 113.2 0.1 4e-32 111.1 0.0 2.2 2 0 0 2 2 2 1 Glycosyltransferase family 28 N-terminal domain GRAM PF02893.20 EDO19109.1 - 1.3e-22 79.9 0.4 2.9e-16 59.3 0.0 3.5 2 1 0 2 2 2 2 GRAM domain UDPGT PF00201.18 EDO19109.1 - 5.5e-13 48.5 0.0 1.5e-12 47.1 0.0 1.6 1 1 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase PH PF00169.29 EDO19109.1 - 3.6e-07 30.6 0.1 2.7e-06 27.8 0.2 2.5 2 0 0 2 2 2 1 PH domain PH_11 PF15413.6 EDO19109.1 - 0.051 14.0 2.6 0.22 11.9 0.2 3.0 2 1 0 2 2 2 0 Pleckstrin homology domain AAA_assoc_2 PF16193.5 EDO19109.1 - 0.072 13.4 0.0 0.22 11.9 0.0 1.8 1 0 0 1 1 1 0 AAA C-terminal domain Abhydrolase_1 PF00561.20 EDO19110.1 - 1.3e-67 228.2 0.1 1.9e-67 227.6 0.1 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EDO19110.1 - 1.9e-05 25.3 0.0 3e-05 24.8 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EDO19110.1 - 0.12 11.7 0.0 0.26 10.5 0.0 1.5 1 0 0 1 1 1 0 Serine aminopeptidase, S33 ABC_membrane PF00664.23 EDO19111.1 - 3.5e-61 207.3 2.2 4.5e-61 206.9 2.2 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 EDO19111.1 - 1.5e-31 109.7 0.0 4.3e-30 105.0 0.0 2.5 2 0 0 2 2 2 1 ABC transporter SMC_N PF02463.19 EDO19111.1 - 2.2e-07 30.5 1.3 2.2e-05 24.0 0.1 2.4 1 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain ABC_ATPase PF09818.9 EDO19111.1 - 0.00054 18.9 0.0 0.00079 18.3 0.0 1.2 1 0 0 1 1 1 1 Predicted ATPase of the ABC class AAA_18 PF13238.6 EDO19111.1 - 0.0013 19.3 0.0 0.029 14.9 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EDO19111.1 - 0.0018 18.7 0.0 0.013 15.9 0.0 2.3 2 1 0 2 2 2 1 AAA ATPase domain AAA_29 PF13555.6 EDO19111.1 - 0.0021 17.7 0.0 0.0063 16.2 0.0 1.8 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_33 PF13671.6 EDO19111.1 - 0.0064 16.6 0.4 0.073 13.2 0.0 2.6 3 0 0 3 3 3 1 AAA domain AAA_21 PF13304.6 EDO19111.1 - 0.015 15.1 0.4 0.12 12.1 0.0 2.5 2 1 1 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 EDO19111.1 - 0.02 15.1 0.1 0.17 12.1 0.1 2.4 1 1 0 1 1 1 0 AAA domain AAA PF00004.29 EDO19111.1 - 0.033 14.6 0.0 0.49 10.8 0.0 2.4 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) DUF1461 PF07314.11 EDO19111.1 - 0.039 13.9 0.0 0.089 12.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1461) AAA_5 PF07728.14 EDO19111.1 - 0.052 13.6 0.0 0.18 11.8 0.0 2.0 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_30 PF13604.6 EDO19111.1 - 0.073 12.8 0.0 9.3 5.9 0.0 3.0 3 0 0 3 3 3 0 AAA domain DEAD PF00270.29 EDO19111.1 - 0.078 12.7 0.0 13 5.5 0.0 2.4 2 0 0 2 2 2 0 DEAD/DEAH box helicase RsgA_GTPase PF03193.16 EDO19111.1 - 0.079 12.9 0.5 0.26 11.2 0.0 2.1 2 0 0 2 2 1 0 RsgA GTPase AAA_7 PF12775.7 EDO19111.1 - 0.09 12.3 0.0 0.21 11.1 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region IstB_IS21 PF01695.17 EDO19111.1 - 0.095 12.4 0.1 9.5 5.9 0.0 2.5 2 0 0 2 2 2 0 IstB-like ATP binding protein PH PF00169.29 EDO19112.1 - 3.4e-06 27.5 0.2 0.00016 22.2 0.0 2.5 2 0 0 2 2 2 1 PH domain EMG1 PF03587.14 EDO19113.1 - 2e-78 262.6 0.0 2.3e-78 262.3 0.0 1.0 1 0 0 1 1 1 1 EMG1/NEP1 methyltransferase LCD1 PF09798.9 EDO19114.1 - 5.1e-205 682.6 46.2 5.8e-205 682.4 46.2 1.0 1 0 0 1 1 1 1 DNA damage checkpoint protein DUF3439 PF11921.8 EDO19114.1 - 0.29 11.1 3.6 0.6 10.1 3.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Asp-B-Hydro_N PF05279.11 EDO19114.1 - 0.35 10.9 6.8 0.78 9.8 6.8 1.5 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region DivIC PF04977.15 EDO19114.1 - 2 8.3 12.1 0.49 10.2 2.0 2.8 2 0 0 2 2 2 0 Septum formation initiator Ribosomal_L37e PF01907.19 EDO19115.1 - 3.4e-28 97.6 11.4 5.3e-28 96.9 11.4 1.3 1 0 0 1 1 1 1 Ribosomal protein L37e DZR PF12773.7 EDO19115.1 - 0.0048 16.9 1.7 0.0068 16.4 1.7 1.2 1 0 0 1 1 1 1 Double zinc ribbon SelR PF01641.18 EDO19115.1 - 0.024 14.7 0.8 0.031 14.4 0.8 1.3 1 1 0 1 1 1 0 SelR domain zf-RING_5 PF14634.6 EDO19115.1 - 0.033 14.1 3.3 0.049 13.6 3.3 1.2 1 0 0 1 1 1 0 zinc-RING finger domain DUF1258 PF06869.12 EDO19115.1 - 0.28 10.6 4.7 0.18 11.3 3.1 1.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1258) zinc_ribbon_2 PF13240.6 EDO19115.1 - 0.64 9.8 5.5 9.2 6.1 1.1 2.3 2 0 0 2 2 2 0 zinc-ribbon domain GATA PF00320.27 EDO19115.1 - 0.85 9.3 9.1 0.73 9.5 1.1 2.5 2 1 1 3 3 3 0 GATA zinc finger FHA PF00498.26 EDO19116.1 - 4.5e-07 30.1 0.0 1.7e-06 28.3 0.0 2.0 1 0 0 1 1 1 1 FHA domain DUF963 PF06131.11 EDO19116.1 - 0.7 9.4 4.3 0.39 10.2 1.4 2.2 2 0 0 2 2 2 0 Schizosaccharomyces pombe repeat of unknown function (DUF963) Vta1_C PF18097.1 EDO19117.1 - 7.2e-15 54.4 0.2 1.3e-14 53.6 0.2 1.4 1 0 0 1 1 1 1 Vta1 C-terminal domain Vta1 PF04652.16 EDO19117.1 - 3.3e-11 43.3 0.2 1.1e-10 41.6 0.0 2.0 2 0 0 2 2 2 1 Vta1 like GET2 PF08690.10 EDO19117.1 - 0.44 10.2 9.2 0.63 9.7 9.2 1.3 1 0 0 1 1 1 0 GET complex subunit GET2 PA26 PF04636.13 EDO19117.1 - 0.9 8.4 4.7 1.3 7.8 4.7 1.3 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) S-AdoMet_synt_C PF02773.16 EDO19118.1 - 6.9e-65 217.2 0.0 1.3e-64 216.3 0.0 1.5 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, C-terminal domain S-AdoMet_synt_N PF00438.20 EDO19118.1 - 6e-46 155.2 0.1 1.2e-45 154.2 0.1 1.5 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, N-terminal domain S-AdoMet_synt_M PF02772.16 EDO19118.1 - 9.7e-46 154.9 0.0 2e-45 153.9 0.0 1.5 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, central domain AdoMet_Synthase PF01941.19 EDO19118.1 - 0.038 12.8 0.3 0.15 10.8 0.2 1.9 1 1 1 2 2 2 0 S-adenosylmethionine synthetase (AdoMet synthetase) PAP2 PF01569.21 EDO19119.1 - 3.4e-28 98.1 1.2 3.6e-28 98.0 0.2 1.6 2 0 0 2 2 2 1 PAP2 superfamily PAP2_3 PF14378.6 EDO19119.1 - 3e-05 23.8 0.0 6.8e-05 22.6 0.0 1.6 1 0 0 1 1 1 1 PAP2 superfamily PAP2_C PF14360.6 EDO19119.1 - 0.0013 19.2 5.4 0.0013 19.2 5.4 2.6 4 0 0 4 4 4 1 PAP2 superfamily C-terminal TMEM190 PF15431.6 EDO19119.1 - 2.6 8.2 5.4 10 6.3 0.0 2.9 3 1 0 3 3 3 0 Transmembrane protein 190 FUSC_2 PF13515.6 EDO19119.1 - 3.9 7.6 7.9 0.84 9.8 2.7 2.2 2 0 0 2 2 2 0 Fusaric acid resistance protein-like PBP PF01161.20 EDO19120.1 - 6.2e-22 78.3 0.1 8.4e-22 77.9 0.1 1.2 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein PSP1 PF04468.12 EDO19121.1 - 2e-41 140.1 0.7 2e-41 140.1 0.7 3.3 4 0 0 4 4 4 1 PSP1 C-terminal conserved region Cu-oxidase_2 PF07731.14 EDO19122.1 - 1.7e-29 102.3 1.6 3.5e-27 94.8 0.5 3.0 3 0 0 3 3 3 2 Multicopper oxidase Cu-oxidase_3 PF07732.15 EDO19122.1 - 7.2e-24 84.1 8.8 5.6e-21 74.8 1.9 4.4 4 1 0 4 4 4 2 Multicopper oxidase Cu-oxidase PF00394.22 EDO19122.1 - 3.4e-22 79.3 0.1 3.6e-20 72.7 0.1 3.1 2 1 1 3 3 3 1 Multicopper oxidase HVSL PF09749.9 EDO19122.1 - 0.015 14.8 0.2 0.051 13.1 0.0 1.8 2 0 0 2 2 2 0 Uncharacterised conserved protein Oxidored_FMN PF00724.20 EDO19123.1 - 1.7e-49 169.0 0.0 3.6e-49 167.9 0.0 1.4 1 1 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Dus PF01207.17 EDO19123.1 - 0.0035 16.5 0.0 0.0079 15.3 0.0 1.5 1 1 0 1 1 1 1 Dihydrouridine synthase (Dus) UPF0236 PF06782.11 EDO19123.1 - 0.036 12.7 0.0 0.054 12.1 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0236) RsbU_N PF08673.10 EDO19123.1 - 0.099 12.7 0.1 9.5 6.4 0.0 2.5 2 0 0 2 2 2 0 Phosphoserine phosphatase RsbU, N-terminal domain AA_permease PF00324.21 EDO19124.1 - 2.1e-133 445.4 29.7 2.4e-133 445.2 29.7 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EDO19124.1 - 8.6e-38 130.3 30.6 1e-37 130.0 30.6 1.0 1 0 0 1 1 1 1 Amino acid permease Nitroreductase PF00881.24 EDO19125.1 - 3.1e-07 30.6 0.0 3.6e-07 30.4 0.0 1.1 1 0 0 1 1 1 1 Nitroreductase family Nitroreductase PF00881.24 EDO19126.1 - 8e-07 29.3 0.0 9.8e-07 29.0 0.0 1.1 1 0 0 1 1 1 1 Nitroreductase family RRM_3 PF08777.11 EDO19126.1 - 0.19 11.8 0.0 0.43 10.6 0.0 1.6 2 0 0 2 2 2 0 RNA binding motif SKG6 PF08693.10 EDO19127.1 - 3.4e-06 26.4 0.0 6.4e-06 25.5 0.0 1.5 1 0 0 1 1 1 1 Transmembrane alpha-helix domain DUF4448 PF14610.6 EDO19127.1 - 5.1e-05 23.1 0.3 0.00013 21.8 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF4448) SH3_9 PF14604.6 EDO19127.1 - 0.00036 20.3 0.0 0.00069 19.4 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EDO19127.1 - 0.0026 17.3 0.0 0.0054 16.3 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 EDO19127.1 - 0.074 12.8 0.1 0.17 11.6 0.1 1.6 1 0 0 1 1 1 0 Variant SH3 domain SAM_Ste50p PF09235.10 EDO19128.1 - 4.1e-24 84.6 1.4 8.6e-24 83.6 1.4 1.6 1 0 0 1 1 1 1 Ste50p, sterile alpha motif RA PF00788.23 EDO19128.1 - 1.5e-14 54.3 0.7 9e-14 51.9 0.1 2.4 3 0 0 3 3 3 1 Ras association (RalGDS/AF-6) domain SAM_1 PF00536.30 EDO19128.1 - 0.034 14.6 0.0 0.088 13.3 0.0 1.7 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 EDO19128.1 - 0.046 13.7 0.1 0.097 12.6 0.1 1.5 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain DUF3128 PF11326.8 EDO19129.1 - 2.7e-27 95.0 3.2 3e-27 94.8 3.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3128) SelR PF01641.18 EDO19130.1 - 4.6e-48 162.3 1.6 5.2e-48 162.1 1.6 1.0 1 0 0 1 1 1 1 SelR domain Yippee-Mis18 PF03226.14 EDO19130.1 - 0.00028 21.1 0.3 0.00045 20.4 0.3 1.3 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly zinc_ribbon_10 PF10058.9 EDO19130.1 - 0.0075 16.0 3.0 0.72 9.6 0.3 2.5 2 0 0 2 2 2 2 Predicted integral membrane zinc-ribbon metal-binding protein HNH_5 PF14279.6 EDO19130.1 - 0.011 15.6 1.1 0.25 11.2 0.1 2.4 2 0 0 2 2 2 0 HNH endonuclease zf-H2C2_2 PF13465.6 EDO19130.1 - 0.012 16.0 5.3 0.32 11.5 0.9 2.4 2 0 0 2 2 2 0 Zinc-finger double domain GFA PF04828.14 EDO19130.1 - 0.17 12.3 3.7 3.3 8.1 0.3 2.2 1 1 1 2 2 2 0 Glutathione-dependent formaldehyde-activating enzyme Tnp_zf-ribbon_2 PF13842.6 EDO19130.1 - 0.72 10.7 7.1 2.6 8.9 0.3 2.6 2 1 0 2 2 2 0 DDE_Tnp_1-like zinc-ribbon Endonuclease_7 PF02945.15 EDO19130.1 - 0.77 9.7 6.2 5.4 7.0 6.2 2.0 1 1 0 1 1 1 0 Recombination endonuclease VII Ribosomal_L37e PF01907.19 EDO19130.1 - 0.91 9.7 7.0 0.24 11.6 0.4 2.3 2 0 0 2 2 2 0 Ribosomal protein L37e Glutaredoxin PF00462.24 EDO19131.1 - 2e-12 47.2 0.0 3.7e-12 46.3 0.0 1.5 1 0 0 1 1 1 1 Glutaredoxin Thioredoxin_3 PF13192.6 EDO19131.1 - 0.0069 16.4 0.0 0.011 15.7 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin domain Ribosomal_L5 PF00281.19 EDO19131.1 - 0.044 14.1 0.2 8.8 6.8 0.0 2.3 2 0 0 2 2 2 0 Ribosomal protein L5 Thioredoxin_2 PF13098.6 EDO19131.1 - 0.06 13.8 0.1 0.1 13.1 0.1 1.4 1 1 0 1 1 1 0 Thioredoxin-like domain REJ PF02010.15 EDO19131.1 - 0.068 12.0 0.0 0.078 11.8 0.0 1.1 1 0 0 1 1 1 0 REJ domain Thioredoxin_4 PF13462.6 EDO19131.1 - 0.085 13.0 0.2 0.15 12.2 0.2 1.4 1 1 0 1 1 1 0 Thioredoxin USP7_ICP0_bdg PF12436.8 EDO19131.1 - 0.15 11.4 0.0 0.18 11.1 0.0 1.2 1 0 0 1 1 1 0 ICP0-binding domain of Ubiquitin-specific protease 7 La PF05383.17 EDO19133.1 - 5.4e-19 68.0 0.2 5.4e-18 64.8 0.0 2.4 2 0 0 2 2 2 1 La domain AXH PF08517.12 EDO19133.1 - 0.0089 16.6 0.0 0.0089 16.6 0.0 2.3 2 2 0 2 2 2 1 Ataxin-1 and HBP1 module (AXH) Presenilin PF01080.17 EDO19133.1 - 3.5 6.3 9.9 4.5 5.9 9.9 1.2 1 0 0 1 1 1 0 Presenilin ATG22 PF11700.8 EDO19134.1 - 1.1e-163 545.3 26.7 1.3e-163 545.1 26.7 1.0 1 0 0 1 1 1 1 Vacuole effluxer Atg22 like MFS_1 PF07690.16 EDO19134.1 - 9.5e-10 37.9 33.1 2e-06 27.0 4.9 3.3 1 1 1 3 3 3 3 Major Facilitator Superfamily Hexokinase_2 PF03727.16 EDO19135.1 - 1.7e-77 260.1 0.0 2.5e-77 259.6 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 EDO19135.1 - 3.3e-72 242.6 0.0 9.6e-72 241.1 0.0 1.7 2 0 0 2 2 2 1 Hexokinase RecG_N PF17190.4 EDO19135.1 - 0.32 11.7 2.1 1.7 9.4 0.1 3.0 3 0 0 3 3 3 0 RecG N-terminal helical domain Thioredoxin PF00085.20 EDO19136.1 - 8.8e-58 192.7 1.7 4.4e-32 110.1 0.2 3.5 3 0 0 3 3 3 2 Thioredoxin Thioredoxin_6 PF13848.6 EDO19136.1 - 2.4e-28 99.3 8.3 8.3e-24 84.5 4.4 2.9 2 1 1 3 3 3 2 Thioredoxin-like domain OST3_OST6 PF04756.13 EDO19136.1 - 9.8e-11 41.5 0.2 0.0001 21.8 0.0 3.2 2 1 1 3 3 3 2 OST3 / OST6 family, transporter family Thioredoxin_7 PF13899.6 EDO19136.1 - 1.7e-07 31.3 0.1 0.0078 16.4 0.0 2.8 2 0 0 2 2 2 2 Thioredoxin-like Thioredoxin_2 PF13098.6 EDO19136.1 - 2.3e-07 31.2 2.7 0.00021 21.7 0.1 3.6 3 1 0 3 3 3 2 Thioredoxin-like domain Thioredoxin_8 PF13905.6 EDO19136.1 - 2.2e-05 24.7 3.5 0.22 11.9 0.0 4.3 4 1 0 4 4 4 2 Thioredoxin-like AhpC-TSA PF00578.21 EDO19136.1 - 0.00062 19.7 0.1 0.096 12.6 0.1 3.0 3 0 0 3 3 3 1 AhpC/TSA family Redoxin PF08534.10 EDO19136.1 - 0.0025 17.5 0.0 1.6 8.4 0.0 2.5 2 0 0 2 2 2 2 Redoxin FKBP_C PF00254.28 EDO19137.1 - 6.1e-32 109.8 0.0 7.7e-32 109.5 0.0 1.1 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase Pmp3 PF01679.17 EDO19138.1 - 1.3e-17 63.7 8.5 1.5e-17 63.5 8.5 1.1 1 0 0 1 1 1 1 Proteolipid membrane potential modulator ATP_transf PF09830.9 EDO19139.1 - 1.4e-20 73.2 0.0 2.4e-20 72.4 0.0 1.4 1 0 0 1 1 1 1 ATP adenylyltransferase DUF4931 PF16285.5 EDO19139.1 - 1.1e-05 24.9 0.1 0.00011 21.6 0.0 2.1 1 1 1 2 2 2 1 Domain of unknown function (DUF4931) DUF4922 PF16269.5 EDO19139.1 - 0.0093 15.7 0.0 0.017 14.9 0.0 1.7 1 1 0 1 1 1 1 Domain of unknown function (DUF4922) UCR_14kD PF02271.16 EDO19140.1 - 6.3e-38 128.8 0.1 7.3e-38 128.6 0.1 1.0 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase complex 14kD subunit Aldo_ket_red PF00248.21 EDO19141.1 - 2.9e-63 213.8 0.1 3.3e-63 213.6 0.1 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Ras PF00071.22 EDO19141.1 - 0.053 13.1 0.0 0.11 12.1 0.0 1.5 1 0 0 1 1 1 0 Ras family Flocculin PF00624.18 EDO19142.1 - 3.6e-148 481.6 1463.3 2.1e-11 43.9 12.5 62.0 44 1 18 62 62 62 32 Flocculin repeat Helicase_C PF00271.31 EDO19144.1 - 4.8e-17 62.3 1.9 7.8e-17 61.6 0.5 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 EDO19144.1 - 5.7e-07 29.5 0.1 1.2e-05 25.1 0.0 2.7 2 1 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.15 EDO19144.1 - 0.0074 16.3 2.4 0.049 13.6 0.0 2.9 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit Terminase_6 PF03237.15 EDO19144.1 - 0.036 13.7 0.1 0.12 12.0 0.1 1.9 2 0 0 2 2 2 0 Terminase-like family SF3a60_bindingd PF12108.8 EDO19144.1 - 0.099 12.5 0.0 0.28 11.1 0.0 1.8 1 0 0 1 1 1 0 Splicing factor SF3a60 binding domain PQ-loop PF04193.14 EDO19146.1 - 2.6e-06 27.1 3.2 2.6e-06 27.1 3.2 3.7 4 1 1 5 5 5 2 PQ loop repeat Rer1 PF03248.13 EDO19147.1 - 3.5e-73 244.9 7.4 4.1e-73 244.7 7.4 1.0 1 0 0 1 1 1 1 Rer1 family DUF4131 PF13567.6 EDO19147.1 - 0.47 10.1 4.0 8.4 6.0 0.5 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) eRF1_2 PF03464.15 EDO19148.1 - 1.6e-27 96.4 0.2 2.8e-27 95.6 0.2 1.4 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.15 EDO19148.1 - 1.6e-26 93.0 0.1 4.2e-26 91.6 0.1 1.8 1 0 0 1 1 1 1 eRF1 domain 3 eRF1_1 PF03463.15 EDO19148.1 - 9.1e-22 77.4 0.3 1.4e-21 76.8 0.3 1.3 1 0 0 1 1 1 1 eRF1 domain 1 DUF4912 PF16258.5 EDO19148.1 - 0.02 15.1 0.0 0.043 14.0 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4912) Peptidase_C16 PF01831.17 EDO19148.1 - 0.046 13.5 0.0 0.51 10.0 0.0 2.2 2 0 0 2 2 2 0 Peptidase C16 family Ribosomal_L32p PF01783.23 EDO19150.1 - 6e-13 48.8 6.1 1e-12 48.1 6.1 1.4 1 0 0 1 1 1 1 Ribosomal L32p protein family zf-ribbon_3 PF13248.6 EDO19150.1 - 0.27 10.7 4.8 0.72 9.3 4.8 1.7 1 1 0 1 1 1 0 zinc-ribbon domain FMN_red PF03358.15 EDO19151.1 - 3.1e-07 30.3 0.0 4.8e-07 29.6 0.0 1.3 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_1 PF00258.25 EDO19151.1 - 5.4e-06 26.7 0.0 9.4e-06 25.9 0.0 1.4 1 0 0 1 1 1 1 Flavodoxin Flavodoxin_5 PF12724.7 EDO19151.1 - 0.018 15.3 0.1 20 5.4 0.0 3.0 2 1 1 3 3 3 0 Flavodoxin domain Flavodoxin_2 PF02525.17 EDO19151.1 - 0.019 14.7 0.0 0.029 14.1 0.0 1.3 1 0 0 1 1 1 0 Flavodoxin-like fold Rad21_Rec8_N PF04825.13 EDO19153.1 - 2e-14 53.7 0.1 7.1e-14 51.9 0.1 1.9 1 0 0 1 1 1 1 N terminus of Rad21 / Rec8 like protein HGAL PF15666.5 EDO19153.1 - 0.13 12.4 1.4 0.2 11.8 0.2 2.0 2 0 0 2 2 2 0 Germinal center-associated lymphoma APOBEC4_like PF18774.1 EDO19154.1 - 0.32 10.9 7.2 0.48 10.4 7.2 1.4 1 0 0 1 1 1 0 APOBEC4-like -AID/APOBEC-deaminase NAD2 PF18782.1 EDO19154.1 - 0.35 10.9 12.8 0.24 11.5 4.3 2.2 1 1 1 2 2 2 0 Novel AID APOBEC clade 2 APOBEC2 PF18772.1 EDO19154.1 - 0.39 10.8 16.9 5.7 6.9 16.9 2.1 1 1 0 1 1 1 0 APOBEC2 NAD1 PF18778.1 EDO19154.1 - 2.7 8.1 17.1 3.1 7.9 11.8 2.1 1 1 1 2 2 2 0 Novel AID APOBEC clade 1 SNAD4 PF18750.1 EDO19154.1 - 5.4 7.2 14.0 19 5.4 14.0 1.9 1 1 0 1 1 1 0 Secreted Novel AID/APOBEC-like Deaminase 4 rve PF00665.26 EDO19155.1 - 7.3e-07 29.4 0.0 9.4e-07 29.0 0.0 1.1 1 0 0 1 1 1 1 Integrase core domain Pkinase PF00069.25 EDO19156.1 - 1.9e-50 171.7 0.0 3.8e-50 170.7 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO19156.1 - 5.4e-27 94.7 0.0 8e-27 94.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDO19156.1 - 0.02 14.2 0.0 0.039 13.3 0.0 1.4 1 0 0 1 1 1 0 Kinase-like Kdo PF06293.14 EDO19156.1 - 0.04 13.3 0.0 0.085 12.2 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EDO19156.1 - 0.11 12.4 0.0 0.18 11.7 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family BAR PF03114.18 EDO19157.1 - 7.8e-36 123.9 2.9 8.8e-36 123.7 2.9 1.0 1 0 0 1 1 1 1 BAR domain CREPT PF16566.5 EDO19157.1 - 0.00041 20.5 0.4 0.00061 20.0 0.4 1.3 1 0 0 1 1 1 1 Cell-cycle alteration and expression-elevated protein in tumour BAR_3 PF16746.5 EDO19157.1 - 0.0024 17.6 0.5 0.0032 17.2 0.5 1.1 1 0 0 1 1 1 1 BAR domain of APPL family AIP3 PF03915.13 EDO19157.1 - 0.0068 15.5 0.1 0.0073 15.4 0.1 1.1 1 0 0 1 1 1 1 Actin interacting protein 3 DUF4164 PF13747.6 EDO19157.1 - 0.012 15.9 2.3 0.015 15.6 0.8 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4164) CENP-F_leu_zip PF10473.9 EDO19157.1 - 0.023 14.7 0.1 0.037 14.1 0.1 1.3 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Jnk-SapK_ap_N PF09744.9 EDO19157.1 - 0.04 14.1 3.0 0.068 13.4 3.0 1.3 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 BRE1 PF08647.11 EDO19157.1 - 0.079 13.0 3.2 0.16 12.1 3.2 1.5 1 0 0 1 1 1 0 BRE1 E3 ubiquitin ligase Fib_alpha PF08702.10 EDO19157.1 - 0.11 12.7 0.3 0.22 11.7 0.1 1.5 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family DUF5339 PF17274.2 EDO19157.1 - 2.2 9.2 5.2 64 4.5 4.7 2.9 2 1 0 2 2 2 0 Family of unknown function (DUF5339) ABC2_membrane PF01061.24 EDO19159.1 - 4.2e-37 127.6 18.0 4.2e-37 127.6 18.0 1.7 2 0 0 2 2 2 1 ABC-2 type transporter ABC_tran PF00005.27 EDO19159.1 - 2.2e-27 96.2 0.2 6.5e-27 94.7 0.0 1.8 2 0 0 2 2 2 1 ABC transporter Rad17 PF03215.15 EDO19159.1 - 0.0016 18.4 0.0 0.0043 17.0 0.0 1.7 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_21 PF13304.6 EDO19159.1 - 0.003 17.4 0.8 0.89 9.3 0.3 2.5 1 1 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 EDO19159.1 - 0.0036 17.2 1.1 0.0058 16.5 0.1 1.8 2 0 0 2 2 2 1 RsgA GTPase AAA_29 PF13555.6 EDO19159.1 - 0.013 15.3 1.6 0.035 13.9 0.3 2.3 3 0 0 3 3 3 0 P-loop containing region of AAA domain AAA_16 PF13191.6 EDO19159.1 - 0.054 13.9 0.1 0.12 12.7 0.1 1.6 1 1 0 1 1 1 0 AAA ATPase domain AAA_24 PF13479.6 EDO19159.1 - 0.085 12.6 0.0 0.16 11.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 EDO19159.1 - 0.088 13.0 0.8 0.16 12.2 0.8 1.4 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 EDO19159.1 - 0.11 13.0 0.2 0.11 13.0 0.2 1.8 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 EDO19159.1 - 0.15 12.3 0.4 0.55 10.5 0.2 2.0 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 EDO19159.1 - 0.21 11.1 0.0 0.46 10.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain ABC_ATPase PF09818.9 EDO19159.1 - 0.22 10.3 0.0 0.34 9.6 0.0 1.2 1 0 0 1 1 1 0 Predicted ATPase of the ABC class Laminin_EGF PF00053.24 EDO19159.1 - 0.9 9.7 28.2 0.068 13.3 6.3 3.6 3 0 0 3 3 3 0 Laminin EGF domain PGK PF00162.19 EDO19160.1 - 6.7e-150 499.2 0.2 7.5e-150 499.1 0.2 1.0 1 0 0 1 1 1 1 Phosphoglycerate kinase DNA_pol_B_thumb PF14791.6 EDO19161.1 - 5.3e-18 64.9 0.2 5.3e-18 64.9 0.2 2.3 2 1 0 2 2 1 1 DNA polymerase beta thumb HHH_8 PF14716.6 EDO19161.1 - 7.3e-17 61.5 0.0 3.7e-16 59.2 0.1 2.1 2 0 0 2 2 2 1 Helix-hairpin-helix domain DNA_pol_B_palm PF14792.6 EDO19161.1 - 3.9e-11 43.2 0.0 5.3e-10 39.5 0.0 2.4 1 1 0 1 1 1 1 DNA polymerase beta palm DNA_pol_lambd_f PF10391.9 EDO19161.1 - 1.3e-10 40.9 0.0 1e-09 38.1 0.0 2.5 3 0 0 3 3 2 1 Fingers domain of DNA polymerase lambda Trypan_PARP PF05887.11 EDO19161.1 - 5.6e-06 26.4 8.9 9.3e-06 25.7 8.9 1.2 1 0 0 1 1 1 1 Procyclic acidic repetitive protein (PARP) CDC45 PF02724.14 EDO19161.1 - 0.00063 18.2 7.4 0.00086 17.7 7.4 1.1 1 0 0 1 1 1 1 CDC45-like protein DDHD PF02862.17 EDO19161.1 - 0.002 18.3 1.8 0.0032 17.7 1.8 1.4 1 0 0 1 1 1 1 DDHD domain Cdd1 PF11731.8 EDO19161.1 - 0.011 15.9 0.0 2.1 8.6 0.0 2.7 1 1 0 2 2 2 0 Pathogenicity locus HHH_5 PF14520.6 EDO19161.1 - 0.021 15.4 0.0 0.08 13.6 0.0 2.0 1 0 0 1 1 1 0 Helix-hairpin-helix domain SID-1_RNA_chan PF13965.6 EDO19161.1 - 0.021 13.2 3.1 0.029 12.8 3.1 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Nop14 PF04147.12 EDO19161.1 - 0.042 12.1 20.9 0.074 11.3 20.9 1.3 1 0 0 1 1 1 0 Nop14-like family Vfa1 PF08432.10 EDO19161.1 - 0.085 13.2 9.8 0.15 12.3 9.8 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 RR_TM4-6 PF06459.12 EDO19161.1 - 0.1 12.4 9.0 0.17 11.7 9.0 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 NPR3 PF03666.13 EDO19161.1 - 0.17 10.6 10.6 0.3 9.8 10.6 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 BEX PF04538.12 EDO19161.1 - 0.28 11.8 13.2 0.53 10.9 13.2 1.3 1 0 0 1 1 1 0 Brain expressed X-linked like family BUD22 PF09073.10 EDO19161.1 - 0.44 9.8 19.5 0.68 9.2 19.5 1.2 1 0 0 1 1 1 0 BUD22 GNAT_acetyltr_2 PF13718.6 EDO19161.1 - 0.8 9.1 5.8 2.3 7.6 0.0 2.4 2 0 0 2 2 2 0 GNAT acetyltransferase 2 NOA36 PF06524.12 EDO19161.1 - 1 8.6 11.8 6.5 6.0 9.3 2.2 2 0 0 2 2 2 0 NOA36 protein Smg8_Smg9 PF10220.9 EDO19161.1 - 1.4 7.1 10.1 2 6.6 10.1 1.1 1 0 0 1 1 1 0 Smg8_Smg9 Zip PF02535.22 EDO19161.1 - 1.7 7.8 6.1 2.3 7.3 6.1 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter RP-C_C PF11800.8 EDO19161.1 - 2.2 8.4 7.9 5.1 7.1 7.9 1.6 1 0 0 1 1 1 0 Replication protein C C-terminal region SDA1 PF05285.12 EDO19161.1 - 3.3 7.1 21.5 5.6 6.3 21.5 1.3 1 0 0 1 1 1 0 SDA1 Dsh_C PF12316.8 EDO19161.1 - 5.1 7.4 13.0 2.1 8.7 10.3 1.6 2 0 0 2 2 2 0 Segment polarity protein dishevelled (Dsh) C terminal GEMIN8 PF15348.6 EDO19161.1 - 5.9 7.1 16.2 11 6.3 16.2 1.3 1 0 0 1 1 1 0 Gemini of Cajal bodies-associated protein 8 Podoplanin PF05808.11 EDO19161.1 - 7 6.7 7.6 11 6.0 7.6 1.3 1 0 0 1 1 1 0 Podoplanin DNA_pol_phi PF04931.13 EDO19161.1 - 8.2 4.4 23.7 8.1 4.4 22.1 1.6 2 0 0 2 2 2 0 DNA polymerase phi Presenilin PF01080.17 EDO19161.1 - 9.5 4.9 13.9 14 4.3 13.9 1.1 1 0 0 1 1 1 0 Presenilin zf-H2C2_2 PF13465.6 EDO19162.1 - 1.7e-07 31.3 18.7 1e-05 25.7 5.0 3.7 4 0 0 4 4 4 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 EDO19162.1 - 1.8e-05 25.2 12.6 0.0055 17.4 3.4 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.26 EDO19162.1 - 1.8e-05 24.9 17.0 0.0035 17.7 3.8 3.0 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-met PF12874.7 EDO19162.1 - 0.08 13.4 0.6 0.08 13.4 0.6 3.4 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf-C2HC_2 PF13913.6 EDO19162.1 - 1.7 8.7 4.9 15 5.7 0.2 3.0 3 0 0 3 3 3 0 zinc-finger of a C2HC-type zf-C2H2_jaz PF12171.8 EDO19162.1 - 9.3 6.7 8.5 3.2 8.2 0.2 3.3 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding ATP_bind_3 PF01171.20 EDO19163.1 - 2.5e-18 66.5 0.0 4.2e-18 65.8 0.0 1.4 1 0 0 1 1 1 1 PP-loop family zn-ribbon_14 PF16503.5 EDO19163.1 - 5.1e-17 61.1 5.3 5.1e-17 61.1 5.3 3.4 3 0 0 3 3 3 1 Zinc-ribbon tRNA_Me_trans PF03054.16 EDO19163.1 - 0.0063 15.3 0.0 0.01 14.6 0.0 1.3 1 0 0 1 1 1 1 tRNA methyl transferase WASH-7_C PF14746.6 EDO19163.1 - 0.049 13.3 0.1 0.51 10.0 0.0 2.1 2 0 0 2 2 2 0 WASH complex subunit 7, C-terminal TF_Zn_Ribbon PF08271.12 EDO19163.1 - 1.9 8.1 7.4 9 5.9 0.1 3.4 3 0 0 3 3 3 0 TFIIB zinc-binding PX PF00787.24 EDO19164.1 - 4.2e-13 49.3 0.3 8.4e-13 48.3 0.3 1.5 1 0 0 1 1 1 1 PX domain DUF16 PF01519.16 EDO19164.1 - 5.5 7.5 12.1 0.65 10.5 6.3 2.3 1 1 1 2 2 2 0 Protein of unknown function DUF16 WD40 PF00400.32 EDO19165.1 - 2.8e-11 43.8 13.3 1.1e-05 26.1 0.5 5.3 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDO19165.1 - 6.2e-09 36.1 0.0 0.00044 20.5 0.0 2.9 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EDO19165.1 - 0.0074 15.0 0.0 0.016 13.9 0.0 1.6 2 0 0 2 2 2 1 Nucleoporin Nup120/160 BBS2_Mid PF14783.6 EDO19165.1 - 0.018 15.1 0.1 0.85 9.7 0.0 3.1 3 0 0 3 3 3 0 Ciliary BBSome complex subunit 2, middle region DUF5364 PF17322.2 EDO19167.1 - 2.4e-60 204.0 18.7 2.7e-60 203.8 18.7 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5364) Flagellin_N PF00669.20 EDO19167.1 - 0.062 13.4 0.3 0.095 12.8 0.3 1.3 1 0 0 1 1 1 0 Bacterial flagellin N-terminal helical region Importin_rep_6 PF18829.1 EDO19167.1 - 0.17 12.0 2.1 0.33 11.1 2.0 1.6 1 1 0 1 1 1 0 Importin repeat 6 MMR1 PF08505.10 EDO19168.1 - 0.0023 18.3 16.5 0.0023 18.3 16.5 2.5 2 1 0 2 2 2 1 Mitochondrial Myo2 receptor-related protein ABC_tran PF00005.27 EDO19169.1 - 1.6e-50 171.2 0.0 8.1e-25 87.9 0.0 2.6 2 0 0 2 2 2 2 ABC transporter ABC_tran_Xtn PF12848.7 EDO19169.1 - 3e-22 78.5 1.4 3e-22 78.5 1.4 2.9 3 0 0 3 3 2 1 ABC transporter AAA_21 PF13304.6 EDO19169.1 - 5.9e-21 75.6 0.6 6.8e-07 29.4 0.0 4.4 3 1 0 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EDO19169.1 - 2.7e-10 40.1 1.7 0.057 12.8 0.1 4.8 3 1 1 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 EDO19169.1 - 1.6e-08 34.7 0.0 0.005 16.6 0.0 3.5 2 1 1 3 3 3 2 AAA ATPase domain RsgA_GTPase PF03193.16 EDO19169.1 - 4.5e-08 33.2 0.3 7.8e-05 22.6 0.0 2.9 3 0 0 3 3 3 1 RsgA GTPase AAA_29 PF13555.6 EDO19169.1 - 2.1e-07 30.6 0.0 0.011 15.5 0.0 2.4 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_23 PF13476.6 EDO19169.1 - 3.9e-07 30.8 7.8 0.027 15.0 0.0 4.1 4 0 0 4 4 3 2 AAA domain AAA_22 PF13401.6 EDO19169.1 - 4.2e-07 30.3 0.0 0.012 15.9 0.0 2.7 2 0 0 2 2 2 2 AAA domain MMR_HSR1 PF01926.23 EDO19169.1 - 8.1e-07 29.1 0.0 0.0025 17.9 0.0 3.0 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA PF00004.29 EDO19169.1 - 4.3e-06 27.2 0.0 0.032 14.6 0.0 3.1 2 1 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 EDO19169.1 - 5.5e-06 26.6 0.0 0.033 14.3 0.0 2.9 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.6 EDO19169.1 - 6.5e-06 26.7 0.0 0.017 15.7 0.0 3.0 3 0 0 3 3 2 1 AAA domain NACHT PF05729.12 EDO19169.1 - 1.2e-05 25.2 1.1 0.14 12.1 0.0 2.9 3 0 0 3 3 2 2 NACHT domain AAA_28 PF13521.6 EDO19169.1 - 1.5e-05 25.3 0.0 0.073 13.3 0.0 2.5 2 0 0 2 2 2 2 AAA domain RNA_helicase PF00910.22 EDO19169.1 - 1.6e-05 25.2 0.0 0.16 12.4 0.0 2.8 2 0 0 2 2 2 2 RNA helicase AAA_16 PF13191.6 EDO19169.1 - 1.7e-05 25.2 0.0 0.04 14.3 0.0 2.7 2 0 0 2 2 2 2 AAA ATPase domain AAA_24 PF13479.6 EDO19169.1 - 0.00015 21.5 0.1 0.31 10.8 0.0 3.1 3 0 0 3 3 3 2 AAA domain Rad17 PF03215.15 EDO19169.1 - 0.00029 20.8 0.0 0.65 9.9 0.0 2.6 2 0 0 2 2 2 2 Rad17 P-loop domain AAA_14 PF13173.6 EDO19169.1 - 0.00038 20.5 0.0 1.1 9.4 0.0 2.9 2 0 0 2 2 2 2 AAA domain MCM PF00493.23 EDO19169.1 - 0.0013 17.9 0.0 0.75 8.8 0.0 2.5 2 0 0 2 2 2 1 MCM P-loop domain TsaE PF02367.17 EDO19169.1 - 0.0026 17.8 0.5 0.6 10.1 0.0 3.0 2 1 1 3 3 3 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE NB-ARC PF00931.22 EDO19169.1 - 0.0033 16.6 0.0 0.43 9.7 0.0 3.2 3 0 0 3 3 3 1 NB-ARC domain Dynamin_N PF00350.23 EDO19169.1 - 0.0034 17.5 1.3 2.9 7.9 0.0 3.8 2 1 0 3 3 3 1 Dynamin family Roc PF08477.13 EDO19169.1 - 0.0034 17.6 0.0 1.4 9.2 0.0 2.7 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase AAA_5 PF07728.14 EDO19169.1 - 0.0035 17.3 0.1 2.6 8.0 0.1 2.7 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) VirE PF05272.11 EDO19169.1 - 0.005 16.6 0.0 1 9.1 0.0 3.0 3 0 0 3 3 3 1 Virulence-associated protein E MeaB PF03308.16 EDO19169.1 - 0.006 15.6 0.1 1 8.2 0.0 2.6 3 0 0 3 3 3 1 Methylmalonyl Co-A mutase-associated GTPase MeaB DUF815 PF05673.13 EDO19169.1 - 0.0062 15.7 0.7 2.2 7.4 0.0 3.0 4 0 0 4 4 2 1 Protein of unknown function (DUF815) AAA_25 PF13481.6 EDO19169.1 - 0.0077 15.8 0.0 2.2 7.8 0.0 3.4 3 1 0 3 3 3 1 AAA domain AAA_7 PF12775.7 EDO19169.1 - 0.011 15.3 0.1 1.1 8.8 0.0 2.7 3 0 0 3 3 2 0 P-loop containing dynein motor region AAA_27 PF13514.6 EDO19169.1 - 0.012 15.3 0.4 3.5 7.2 0.0 2.8 3 0 0 3 3 2 0 AAA domain AAA_30 PF13604.6 EDO19169.1 - 0.014 15.1 0.4 0.79 9.4 0.2 3.1 2 1 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 EDO19169.1 - 0.016 14.9 0.0 0.44 10.2 0.0 2.7 3 0 0 3 3 2 0 IstB-like ATP binding protein G-alpha PF00503.20 EDO19169.1 - 0.017 14.3 1.2 3.4 6.7 0.0 2.8 2 2 1 3 3 3 0 G-protein alpha subunit T2SSE PF00437.20 EDO19169.1 - 0.027 13.5 0.0 0.83 8.7 0.0 2.4 2 1 0 2 2 2 0 Type II/IV secretion system protein NTPase_1 PF03266.15 EDO19169.1 - 0.03 14.2 0.1 0.72 9.7 0.0 2.5 2 0 0 2 2 2 0 NTPase FeoB_N PF02421.18 EDO19169.1 - 0.031 13.8 0.0 1.1 8.8 0.0 2.5 2 0 0 2 2 2 0 Ferrous iron transport protein B DUF87 PF01935.17 EDO19169.1 - 0.034 14.2 1.4 15 5.6 0.0 3.5 3 1 1 4 4 4 0 Helicase HerA, central domain dNK PF01712.19 EDO19169.1 - 0.039 13.8 0.0 5.4 6.8 0.0 2.5 2 0 0 2 2 2 0 Deoxynucleoside kinase PduV-EutP PF10662.9 EDO19169.1 - 0.067 12.9 0.1 17 5.1 0.0 3.0 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation ATPase_2 PF01637.18 EDO19169.1 - 0.076 12.9 0.1 19 5.1 0.0 2.9 3 0 0 3 3 3 0 ATPase domain predominantly from Archaea DUF2813 PF11398.8 EDO19169.1 - 0.086 12.1 0.3 4.3 6.5 0.0 2.6 3 0 0 3 3 2 0 Protein of unknown function (DUF2813) RuvB_N PF05496.12 EDO19169.1 - 0.087 12.6 0.1 0.49 10.1 0.0 2.3 2 0 0 2 2 1 0 Holliday junction DNA helicase RuvB P-loop domain Septin PF00735.18 EDO19169.1 - 0.089 12.1 0.0 9.1 5.5 0.0 2.4 2 0 0 2 2 2 0 Septin AAA_17 PF13207.6 EDO19169.1 - 0.11 12.9 1.6 33 4.9 0.0 3.7 4 0 0 4 4 3 0 AAA domain SRP54 PF00448.22 EDO19169.1 - 0.12 11.9 0.7 3.4 7.3 0.0 3.0 3 0 0 3 3 3 0 SRP54-type protein, GTPase domain CLP1_P PF16575.5 EDO19169.1 - 0.13 12.0 1.0 33 4.2 0.0 3.5 3 0 0 3 3 3 0 mRNA cleavage and polyadenylation factor CLP1 P-loop Hydrolase PF00702.26 EDO19170.1 - 7.6e-08 32.9 0.0 2.8e-06 27.8 0.0 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 EDO19170.1 - 8e-07 29.3 0.0 1.9e-06 28.1 0.0 1.7 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Pneumo_NS1 PF03438.13 EDO19170.1 - 0.024 14.8 0.4 0.64 10.2 0.0 2.7 3 0 0 3 3 3 0 Pneumovirus NS1 protein HAD PF12710.7 EDO19170.1 - 0.19 12.1 0.0 0.26 11.7 0.0 1.2 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase EamA PF00892.20 EDO19171.1 - 5.4e-07 29.9 26.9 0.0015 18.7 13.8 2.1 2 0 0 2 2 2 2 EamA-like transporter family DUF1751 PF08551.10 EDO19171.1 - 0.28 11.8 0.1 0.28 11.8 0.1 3.5 2 2 0 3 3 3 0 Eukaryotic integral membrane protein (DUF1751) Multi_Drug_Res PF00893.19 EDO19171.1 - 5.8 7.6 18.4 0.05 14.3 4.3 3.2 4 0 0 4 4 4 0 Small Multidrug Resistance protein SUI1 PF01253.22 EDO19172.1 - 1.7e-21 76.5 2.8 1.8e-21 76.4 1.7 1.6 1 1 0 1 1 1 1 Translation initiation factor SUI1 TPR_2 PF07719.17 EDO19173.1 - 0.00036 20.4 3.3 9.2 6.7 0.1 5.6 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_19 PF14559.6 EDO19173.1 - 0.0035 17.8 0.1 6.1 7.4 0.0 4.1 3 1 0 4 4 4 1 Tetratricopeptide repeat TPR_14 PF13428.6 EDO19173.1 - 0.0046 17.7 1.3 0.098 13.5 0.0 3.7 4 0 0 4 4 4 1 Tetratricopeptide repeat DUF4186 PF13811.6 EDO19173.1 - 0.11 12.5 0.1 0.47 10.5 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4186) Thi4 PF01946.17 EDO19174.1 - 8.1e-109 362.3 0.4 9.7e-109 362.1 0.4 1.1 1 0 0 1 1 1 1 Thi4 family DAO PF01266.24 EDO19174.1 - 3.1e-06 27.0 2.7 3.4e-06 26.9 0.8 1.8 1 1 1 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EDO19174.1 - 8.6e-06 25.9 0.1 2.3e-05 24.5 0.1 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 EDO19174.1 - 4.6e-05 22.7 2.2 0.0012 18.0 0.8 2.3 2 0 0 2 2 2 1 FAD binding domain NAD_binding_9 PF13454.6 EDO19174.1 - 8.8e-05 22.5 0.1 0.00094 19.2 0.1 2.3 2 0 0 2 2 2 1 FAD-NAD(P)-binding Lycopene_cycl PF05834.12 EDO19174.1 - 0.0011 18.0 0.4 0.0019 17.4 0.4 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein Pyr_redox_2 PF07992.14 EDO19174.1 - 0.0014 17.9 0.2 0.0026 17.1 0.0 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EDO19174.1 - 0.0039 16.6 1.1 0.0065 15.9 1.1 1.4 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 EDO19174.1 - 0.0053 16.1 0.1 0.013 14.8 0.0 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EDO19174.1 - 0.0067 15.2 0.5 0.017 13.8 0.6 1.6 2 0 0 2 2 2 1 HI0933-like protein GIDA PF01134.22 EDO19174.1 - 0.042 12.9 0.1 0.097 11.7 0.1 1.6 2 0 0 2 2 2 0 Glucose inhibited division protein A K_oxygenase PF13434.6 EDO19174.1 - 0.2 10.8 0.0 0.32 10.1 0.0 1.2 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) PMT PF02366.18 EDO19175.1 - 4.3e-92 308.1 24.0 4.3e-92 308.1 24.0 2.3 2 0 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 EDO19175.1 - 1.5e-54 184.6 17.8 1.5e-54 184.6 17.8 2.6 2 1 0 2 2 2 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 EDO19175.1 - 3e-23 82.6 0.7 6.6e-23 81.5 0.7 1.4 1 0 0 1 1 1 1 MIR domain WD40 PF00400.32 EDO19176.1 - 5.6e-36 121.9 11.4 7.9e-07 29.7 0.0 11.2 12 0 0 12 12 12 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDO19176.1 - 1.1e-11 44.9 3.8 0.11 12.9 0.0 7.4 6 2 2 8 8 8 2 Anaphase-promoting complex subunit 4 WD40 domain BBS2_Mid PF14783.6 EDO19176.1 - 3.6e-06 27.0 0.0 3.6 7.7 0.0 5.6 7 0 0 7 7 7 2 Ciliary BBSome complex subunit 2, middle region YmzC PF14157.6 EDO19176.1 - 0.077 13.1 0.5 36 4.5 0.1 3.6 3 0 0 3 3 3 0 YmzC-like protein ILVD_EDD PF00920.21 EDO19177.1 - 7.1e-212 704.6 0.1 8.1e-212 704.4 0.1 1.0 1 0 0 1 1 1 1 Dehydratase family Rhodanese PF00581.20 EDO19178.1 - 3.6e-12 46.7 0.1 4.4e-12 46.5 0.1 1.1 1 0 0 1 1 1 1 Rhodanese-like domain DUF5065 PF16723.5 EDO19178.1 - 0.0074 16.4 0.0 0.0098 16.0 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF5065) FTHFS PF01268.19 EDO19179.1 - 6.4e-251 833.4 0.1 8.9e-251 832.9 0.1 1.2 1 0 0 1 1 1 1 Formate--tetrahydrofolate ligase THF_DHG_CYH_C PF02882.19 EDO19179.1 - 4.1e-61 205.0 0.1 4.1e-61 205.0 0.1 1.8 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH PF00763.23 EDO19179.1 - 4.5e-38 130.1 0.7 1.1e-37 128.8 0.7 1.8 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain DUF1859 PF08948.10 EDO19179.1 - 0.0053 16.7 0.0 3.1 7.8 0.0 2.5 2 0 0 2 2 2 2 Domain of unknown function (DUF1859) AdoHcyase_NAD PF00670.21 EDO19179.1 - 0.052 13.6 0.2 4.1 7.4 0.2 2.7 2 1 0 2 2 2 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain CbiA PF01656.23 EDO19179.1 - 0.1 12.7 0.2 0.65 10.1 0.1 2.1 2 0 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain GTP_EFTU PF00009.27 EDO19179.1 - 0.15 11.6 0.5 0.34 10.4 0.0 1.8 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain Acyl_CoA_thio PF02551.15 EDO19180.1 - 3.1e-39 133.8 2.0 1e-29 103.0 0.4 3.2 2 1 0 2 2 2 2 Acyl-CoA thioesterase 4HBT_3 PF13622.6 EDO19180.1 - 2.5e-35 122.9 0.0 3.6e-35 122.4 0.0 1.2 1 0 0 1 1 1 1 Thioesterase-like superfamily DUF285 PF03382.14 EDO19180.1 - 0.045 13.5 0.0 0.072 12.8 0.0 1.3 1 0 0 1 1 1 0 Mycoplasma protein of unknown function, DUF285 Zeta_toxin PF06414.12 EDO19181.1 - 0.0088 15.3 0.0 0.014 14.7 0.0 1.2 1 0 0 1 1 1 1 Zeta toxin AAA_14 PF13173.6 EDO19181.1 - 0.061 13.4 0.0 0.12 12.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EDO19181.1 - 0.094 13.1 0.0 0.16 12.4 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain SRP54 PF00448.22 EDO19181.1 - 0.17 11.5 0.0 0.24 11.0 0.0 1.2 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain Mer2 PF09074.10 EDO19182.1 - 5e-72 241.8 11.2 5e-72 241.8 11.2 1.5 2 0 0 2 2 2 1 Mer2 Mitofilin PF09731.9 EDO19182.1 - 0.07 12.0 5.1 0.089 11.6 5.1 1.2 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Baculo_PEP_C PF04513.12 EDO19182.1 - 0.09 12.8 6.8 0.51 10.4 0.7 2.5 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus ApoLp-III PF07464.11 EDO19182.1 - 0.15 12.1 8.5 2 8.5 1.8 2.9 1 1 1 2 2 2 0 Apolipophorin-III precursor (apoLp-III) Fzo_mitofusin PF04799.13 EDO19182.1 - 0.2 11.2 5.3 0.13 11.8 0.7 2.6 2 1 1 3 3 3 0 fzo-like conserved region DUF16 PF01519.16 EDO19182.1 - 1.4 9.4 13.1 0.27 11.8 4.8 3.0 3 1 1 4 4 4 0 Protein of unknown function DUF16 Cortex-I_coil PF09304.10 EDO19182.1 - 2.1 8.6 11.9 20 5.5 2.5 4.2 1 1 2 3 3 3 0 Cortexillin I, coiled coil DUF1664 PF07889.12 EDO19182.1 - 5.7 7.0 11.6 0.76 9.8 3.4 3.0 3 1 0 3 3 3 0 Protein of unknown function (DUF1664) Aldolase_II PF00596.21 EDO19183.1 - 4.6e-44 150.6 0.0 5.5e-44 150.3 0.0 1.1 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain 3-HAO PF06052.12 EDO19184.1 - 6.7e-65 217.3 0.0 7.7e-65 217.1 0.0 1.0 1 0 0 1 1 1 1 3-hydroxyanthranilic acid dioxygenase Cupin_2 PF07883.11 EDO19184.1 - 0.0001 22.0 0.0 0.00017 21.2 0.0 1.4 1 0 0 1 1 1 1 Cupin domain zf-ACC PF17848.1 EDO19184.1 - 0.0018 18.3 2.5 0.17 12.0 0.1 2.3 2 0 0 2 2 2 2 Acetyl-coA carboxylase zinc finger domain zf-ribbon_3 PF13248.6 EDO19184.1 - 0.0044 16.4 1.6 0.15 11.5 0.2 2.4 2 0 0 2 2 2 1 zinc-ribbon domain ADK_lid PF05191.14 EDO19184.1 - 0.18 11.8 1.0 13 5.9 0.0 2.7 2 0 0 2 2 2 0 Adenylate kinase, active site lid DZR PF12773.7 EDO19184.1 - 0.33 11.0 2.3 3.2 7.8 2.3 2.2 1 1 0 1 1 1 0 Double zinc ribbon zf-RanBP PF00641.18 EDO19184.1 - 1.2 8.5 4.2 16 4.9 0.4 2.3 2 0 0 2 2 2 0 Zn-finger in Ran binding protein and others Mvb12 PF09452.10 EDO19185.1 - 1e-33 115.6 0.0 1.2e-33 115.4 0.0 1.0 1 0 0 1 1 1 1 ESCRT-I subunit Mvb12 Poty_coat PF00767.18 EDO19185.1 - 0.017 14.7 0.0 0.034 13.7 0.0 1.5 1 1 1 2 2 2 0 Potyvirus coat protein UPF0203 PF05254.12 EDO19185.1 - 0.15 12.3 3.8 0.3 11.4 0.5 2.1 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0203) HAD PF12710.7 EDO19186.1 - 3.9e-13 50.2 0.0 6.3e-13 49.5 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EDO19186.1 - 1.8e-12 48.0 0.1 1.5e-11 45.0 0.0 2.2 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 EDO19186.1 - 2.2e-08 34.2 1.5 9.8e-08 32.0 0.2 2.1 1 1 1 2 2 2 1 haloacid dehalogenase-like hydrolase Put_Phosphatase PF06888.12 EDO19186.1 - 0.0016 17.9 0.9 0.0037 16.7 0.9 1.6 1 1 0 1 1 1 1 Putative Phosphatase HAD_2 PF13419.6 EDO19186.1 - 0.0057 16.8 1.1 2.3 8.2 0.0 2.3 2 0 0 2 2 2 2 Haloacid dehalogenase-like hydrolase S6PP PF05116.13 EDO19186.1 - 0.14 11.7 0.4 1.1 8.7 0.0 2.0 2 0 0 2 2 2 0 Sucrose-6F-phosphate phosphohydrolase MMR_HSR1_C PF08438.10 EDO19187.1 - 8.3e-36 123.0 0.0 1.6e-35 122.1 0.0 1.5 1 0 0 1 1 1 1 GTPase of unknown function C-terminal MMR_HSR1 PF01926.23 EDO19187.1 - 3.2e-20 72.3 0.0 7e-20 71.2 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EDO19187.1 - 6.6e-06 25.7 0.1 2.9e-05 23.6 0.0 2.0 2 0 0 2 2 2 1 Ferrous iron transport protein B FtsK_SpoIIIE PF01580.18 EDO19187.1 - 0.014 14.7 0.5 0.97 8.7 0.2 2.2 2 0 0 2 2 2 0 FtsK/SpoIIIE family GTP_EFTU PF00009.27 EDO19187.1 - 0.017 14.7 0.1 4.1 6.9 0.0 2.5 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 EDO19187.1 - 0.017 15.2 0.2 0.1 12.7 0.1 2.3 3 0 0 3 3 3 0 Dynamin family KTI12 PF08433.10 EDO19187.1 - 0.079 12.4 0.0 0.18 11.2 0.0 1.5 1 0 0 1 1 1 0 Chromatin associated protein KTI12 AAA_24 PF13479.6 EDO19187.1 - 0.12 12.1 0.2 6 6.5 0.0 2.7 3 0 0 3 3 3 0 AAA domain Ploopntkinase3 PF18751.1 EDO19187.1 - 0.14 12.0 0.0 0.37 10.7 0.0 1.6 1 0 0 1 1 1 0 P-loop Nucleotide Kinase3 zf-ZPR1 PF03367.13 EDO19188.1 - 5e-116 384.0 3.5 2.8e-58 196.3 0.3 2.3 2 0 0 2 2 2 2 ZPR1 zinc-finger domain HypA PF01155.19 EDO19188.1 - 0.00069 19.6 3.4 0.12 12.4 0.6 2.4 2 0 0 2 2 2 2 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Cytochrom_C_2 PF01322.20 EDO19188.1 - 0.16 12.9 2.7 27 5.7 0.1 4.1 4 0 0 4 4 4 0 Cytochrome C' zinc_ribbon_4 PF13717.6 EDO19188.1 - 1.8 8.5 6.8 3.2 7.8 0.1 3.4 3 0 0 3 3 3 0 zinc-ribbon domain zinc-ribbons_6 PF07191.12 EDO19188.1 - 2.5 8.1 6.1 2.1 8.4 0.8 2.6 2 1 0 2 2 2 0 zinc-ribbons zinc_ribbon_2 PF13240.6 EDO19188.1 - 9.8 6.0 16.0 28 4.6 0.6 4.4 4 0 0 4 4 4 0 zinc-ribbon domain Ribosomal_S2 PF00318.20 EDO19189.1 - 8.9e-23 80.7 0.0 4.6e-13 48.9 0.0 2.2 1 1 1 2 2 2 2 Ribosomal protein S2 40S_SA_C PF16122.5 EDO19189.1 - 0.0022 19.3 8.9 0.004 18.5 8.9 1.5 1 0 0 1 1 1 1 40S ribosomal protein SA C-terminus Gpi1 PF05024.15 EDO19190.1 - 7.8e-65 218.5 18.3 1.4e-64 217.6 18.3 1.5 1 0 0 1 1 1 1 N-acetylglucosaminyl transferase component (Gpi1) Ion_trans PF00520.31 EDO19191.1 - 5.4e-99 330.4 118.3 2.1e-32 112.3 5.7 5.2 5 0 0 5 5 5 5 Ion transport protein GPHH PF16905.5 EDO19191.1 - 0.1 12.4 0.0 0.24 11.2 0.0 1.6 1 0 0 1 1 1 0 Voltage-dependent L-type calcium channel, IQ-associated CRM1_C PF08767.11 EDO19192.1 - 9.5e-134 445.6 6.0 9.5e-134 445.6 6.0 3.3 3 1 1 4 4 4 1 CRM1 C terminal Xpo1 PF08389.12 EDO19192.1 - 6e-38 130.2 5.5 6e-38 130.2 5.5 4.4 5 0 0 5 5 5 1 Exportin 1-like protein CRM1_repeat_2 PF18784.1 EDO19192.1 - 2.7e-32 110.2 1.4 7.8e-32 108.7 1.4 1.9 1 0 0 1 1 1 1 CRM1 / Exportin repeat 2 CRM1_repeat_3 PF18787.1 EDO19192.1 - 7.8e-30 102.7 0.7 1.9e-28 98.3 0.4 3.4 2 0 0 2 2 2 1 CRM1 / Exportin repeat 3 CRM1_repeat PF18777.1 EDO19192.1 - 4.2e-17 61.3 0.7 4.2e-17 61.3 0.7 2.4 3 0 0 3 3 3 1 Chromosome region maintenance or exportin repeat IBN_N PF03810.19 EDO19192.1 - 1.6e-15 56.8 0.6 1.1e-14 54.0 0.1 2.9 2 0 0 2 2 2 1 Importin-beta N-terminal domain DUF3385 PF11865.8 EDO19192.1 - 0.047 13.6 5.3 0.17 11.8 0.0 3.7 4 0 0 4 4 4 0 Domain of unknown function (DUF3385) SopA PF13981.6 EDO19192.1 - 0.063 13.7 0.6 0.27 11.7 0.6 2.1 1 0 0 1 1 1 0 SopA-like central domain Caud_tail_N PF16838.5 EDO19192.1 - 0.12 12.8 2.8 0.14 12.6 0.1 2.4 2 0 0 2 2 2 0 Caudoviral major tail protein N-terminus Ribosomal_L3 PF00297.22 EDO19193.1 - 6.7e-17 61.5 1.4 1.3e-13 50.7 0.3 2.2 1 1 1 2 2 2 2 Ribosomal protein L3 V-set PF07686.17 EDO19193.1 - 0.19 11.9 0.0 0.36 11.0 0.0 1.5 1 0 0 1 1 1 0 Immunoglobulin V-set domain Ribosomal_L6 PF00347.23 EDO19194.1 - 1.2e-24 86.8 1.0 1.3e-12 48.2 1.4 2.3 2 0 0 2 2 2 2 Ribosomal protein L6 S4 PF01479.25 EDO19195.1 - 1.9e-12 46.7 0.0 1.3e-11 44.0 0.0 2.1 2 0 0 2 2 2 1 S4 domain Ribosomal_S4 PF00163.19 EDO19195.1 - 4.3e-12 46.8 0.8 6.3e-12 46.2 0.8 1.4 1 0 0 1 1 1 1 Ribosomal protein S4/S9 N-terminal domain Herpes_LAMP2 PF06126.11 EDO19195.1 - 0.0079 14.9 0.0 0.0089 14.7 0.0 1.1 1 0 0 1 1 1 1 Herpesvirus Latent membrane protein 2 Pox_A_type_inc PF04508.12 EDO19195.1 - 0.052 13.4 0.2 0.88 9.5 0.0 2.5 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat Baculo_gp41 PF04700.12 EDO19195.1 - 0.057 13.2 0.1 0.084 12.6 0.1 1.3 1 0 0 1 1 1 0 Structural glycoprotein p40/gp41 conserved region SKG6 PF08693.10 EDO19196.1 - 6.2e-14 51.1 3.0 1.1e-13 50.3 3.0 1.4 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Coiled PF05710.12 EDO19196.1 - 0.0042 17.9 0.9 0.0042 17.9 0.9 2.2 2 0 0 2 2 2 1 Coiled coil DUF4448 PF14610.6 EDO19196.1 - 0.052 13.3 0.0 0.052 13.3 0.0 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF4448) PH PF00169.29 EDO19197.1 - 0.012 16.1 0.4 2.4 8.7 0.1 2.3 2 0 0 2 2 2 0 PH domain AGS_C PF18134.1 EDO19197.1 - 0.12 12.4 1.6 1.2 9.2 0.2 2.5 2 1 1 3 3 3 0 Adenylyl/Guanylyl and SMODS C-terminal sensor domain WD40 PF00400.32 EDO19198.1 - 0.00062 20.5 0.0 6.6 7.8 0.0 3.9 3 0 0 3 3 3 2 WD domain, G-beta repeat Ge1_WD40 PF16529.5 EDO19198.1 - 0.0085 15.1 0.5 2.3 7.1 0.0 3.1 2 1 0 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Pex24p PF06398.11 EDO19199.1 - 5.6e-80 269.1 1.0 8.3e-80 268.5 1.0 1.2 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin PRT_C PF08372.10 EDO19199.1 - 0.013 15.2 2.0 0.33 10.7 0.3 2.3 2 0 0 2 2 2 0 Plant phosphoribosyltransferase C-terminal Reticulon PF02453.17 EDO19199.1 - 0.48 10.4 4.3 1.6 8.6 4.4 1.9 1 1 0 1 1 1 0 Reticulon Lectin_C PF00059.21 EDO19200.1 - 3.4e-05 24.5 6.6 0.0041 17.8 2.9 3.0 3 0 0 3 3 3 2 Lectin C-type domain DIE2_ALG10 PF04922.12 EDO19201.1 - 1.5e-113 380.1 33.9 1.5e-113 380.1 33.9 1.5 1 1 1 2 2 2 1 DIE2/ALG10 family Spo12 PF05032.12 EDO19202.1 - 3.9e-16 58.7 1.3 8.4e-16 57.6 1.3 1.6 1 0 0 1 1 1 1 Spo12 family DOMON PF03351.17 EDO19202.1 - 0.043 14.0 0.1 0.089 13.0 0.1 1.6 1 0 0 1 1 1 0 DOMON domain Band_7 PF01145.25 EDO19203.1 - 1.8e-22 80.2 1.5 1.8e-22 80.2 1.5 1.5 2 0 0 2 2 2 1 SPFH domain / Band 7 family Methyltransf_5 PF01795.19 EDO19203.1 - 0.033 13.7 0.7 0.051 13.1 0.7 1.3 1 0 0 1 1 1 0 MraW methylase family DUF3416 PF11896.8 EDO19203.1 - 0.15 12.3 1.3 0.54 10.5 0.7 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF3416) Ank_2 PF12796.7 EDO19204.1 - 1.8e-35 121.3 0.0 7.1e-15 55.4 0.0 3.2 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EDO19204.1 - 7.1e-35 118.6 0.4 1.1e-09 38.3 0.0 5.1 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Ank_4 PF13637.6 EDO19204.1 - 1.1e-33 115.1 1.2 3.9e-13 49.6 0.0 4.2 2 2 2 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EDO19204.1 - 9.6e-31 102.4 0.1 6.9e-05 22.9 0.0 6.0 6 0 0 6 6 6 5 Ankyrin repeat Ank PF00023.30 EDO19204.1 - 8.2e-27 92.5 0.6 2.2e-06 27.8 0.0 5.4 5 0 0 5 5 5 5 Ankyrin repeat RTT107_BRCT_6 PF16771.5 EDO19205.1 - 3e-38 130.5 2.7 2.9e-37 127.3 0.3 3.4 2 0 0 2 2 2 1 Regulator of Ty1 transposition protein 107 BRCT domain RTT107_BRCT_5 PF16770.5 EDO19205.1 - 2e-24 85.4 0.1 2.7e-22 78.5 0.0 4.0 4 0 0 4 4 4 1 Regulator of Ty1 transposition protein 107 BRCT domain BRCT PF00533.26 EDO19205.1 - 1.3e-14 54.3 11.5 0.00011 22.5 0.0 5.9 5 1 0 5 5 5 3 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 EDO19205.1 - 2.6e-13 49.7 0.8 1.6e-07 31.2 0.0 3.6 3 0 0 3 3 3 2 twin BRCT domain BRCT_2 PF16589.5 EDO19205.1 - 2.7e-13 50.1 1.0 0.00021 21.6 0.0 5.4 3 1 1 4 4 4 3 BRCT domain, a BRCA1 C-terminus domain LIG3_BRCT PF16759.5 EDO19205.1 - 0.0046 17.2 0.0 0.25 11.7 0.0 3.4 3 0 0 3 3 3 1 DNA ligase 3 BRCT domain Globin PF00042.22 EDO19206.1 - 1.2e-08 35.5 0.1 1.2e-07 32.2 0.0 2.5 3 0 0 3 3 3 1 Globin NAD_binding_1 PF00175.21 EDO19206.1 - 1.3e-06 29.0 0.0 2.9e-06 27.9 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Protoglobin PF11563.8 EDO19206.1 - 0.015 15.2 0.1 0.04 13.8 0.1 1.8 1 1 0 1 1 1 0 Protoglobin NAD_binding_6 PF08030.12 EDO19206.1 - 0.21 11.7 0.6 1.1 9.4 0.6 2.1 1 1 1 2 2 2 0 Ferric reductase NAD binding domain ApoO PF09769.9 EDO19207.1 - 5e-27 94.4 0.0 7e-27 94.0 0.0 1.2 1 0 0 1 1 1 1 Apolipoprotein O REC104 PF17378.2 EDO19210.1 - 0.00017 21.4 0.2 0.00017 21.4 0.2 2.7 2 1 0 3 3 3 1 Meiotic recombination protein REC104 Propeptide_C25 PF08126.11 EDO19210.1 - 0.014 14.5 0.7 0.023 13.8 0.7 1.2 1 0 0 1 1 1 0 Propeptide_C25 Kelch_3 PF13415.6 EDO19211.1 - 1.5e-28 98.5 2.1 1.7e-05 25.0 0.1 5.8 5 0 0 5 5 5 5 Galactose oxidase, central domain Kelch_4 PF13418.6 EDO19211.1 - 2.9e-26 91.2 11.7 1.2e-05 25.2 0.4 6.7 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_5 PF13854.6 EDO19211.1 - 4.2e-26 90.5 8.7 5.9e-06 26.1 0.1 6.5 6 0 0 6 6 6 4 Kelch motif Kelch_6 PF13964.6 EDO19211.1 - 6.5e-26 89.7 11.2 8.3e-08 32.3 0.2 6.5 5 1 1 6 6 6 5 Kelch motif Kelch_1 PF01344.25 EDO19211.1 - 3.2e-19 68.3 2.0 3e-05 23.5 0.0 5.6 6 0 0 6 6 6 4 Kelch motif Kelch_2 PF07646.15 EDO19211.1 - 2.5e-13 49.4 8.7 0.17 11.9 0.0 6.9 6 1 0 6 6 6 4 Kelch motif TPR_MLP1_2 PF07926.12 EDO19211.1 - 0.0027 17.7 10.5 0.0027 17.7 10.5 5.8 4 2 0 5 5 5 1 TPR/MLP1/MLP2-like protein TDA11 PF17084.5 EDO19212.1 - 2.2e-273 907.2 39.0 2.6e-273 907.0 39.0 1.0 1 0 0 1 1 1 1 Topoisomerase I damage affected protein 11 IL32 PF15225.6 EDO19212.1 - 0.029 14.7 0.0 0.073 13.4 0.0 1.7 1 0 0 1 1 1 0 Interleukin 32 PFK PF00365.20 EDO19214.1 - 2.4e-185 614.5 0.7 1.2e-103 346.4 0.1 2.2 2 0 0 2 2 2 2 Phosphofructokinase Pfk_N PF18468.1 EDO19214.1 - 2.6e-26 91.9 0.0 6.9e-26 90.5 0.0 1.8 1 0 0 1 1 1 1 Phosphofructokinase N-terminal domain yeast Ribosomal_S11 PF00411.19 EDO19214.1 - 0.039 14.4 0.0 0.14 12.6 0.0 2.0 1 0 0 1 1 1 0 Ribosomal protein S11 DAGK_cat PF00781.24 EDO19214.1 - 0.072 12.7 0.2 0.62 9.7 0.1 2.6 2 0 0 2 2 2 0 Diacylglycerol kinase catalytic domain DAP_epimerase PF01678.19 EDO19214.1 - 0.088 13.0 0.0 1.5 9.0 0.0 2.4 2 0 0 2 2 2 0 Diaminopimelate epimerase OCC1 PF15506.6 EDO19214.1 - 0.12 12.5 0.0 0.53 10.4 0.0 2.1 2 0 0 2 2 2 0 OCC1 family ATP-grasp_2 PF08442.10 EDO19215.1 - 6.5e-68 228.3 0.4 9.9e-68 227.7 0.4 1.3 1 0 0 1 1 1 1 ATP-grasp domain Ligase_CoA PF00549.19 EDO19215.1 - 9.5e-21 74.2 0.1 2e-20 73.1 0.1 1.6 1 0 0 1 1 1 1 CoA-ligase CPDase PF07823.11 EDO19217.1 - 4.9e-66 222.2 0.0 5.8e-66 222.0 0.0 1.1 1 0 0 1 1 1 1 Cyclic phosphodiesterase-like protein 2_5_RNA_ligase2 PF13563.6 EDO19217.1 - 0.00018 21.5 0.0 0.0024 17.8 0.0 2.0 1 1 1 2 2 2 2 2'-5' RNA ligase superfamily Glucosamine_iso PF01182.20 EDO19218.1 - 4.8e-62 209.8 0.0 5.4e-62 209.6 0.0 1.0 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase HSF_DNA-bind PF00447.17 EDO19219.1 - 4.6e-23 81.6 2.6 1e-22 80.5 2.6 1.6 1 0 0 1 1 1 1 HSF-type DNA-binding Ets PF00178.22 EDO19219.1 - 0.057 13.9 0.1 0.13 12.7 0.1 1.6 1 0 0 1 1 1 0 Ets-domain SLATT_5 PF18160.1 EDO19219.1 - 0.082 12.2 1.0 11 5.2 0.4 2.3 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain family 5 Dna2 PF08696.11 EDO19220.1 - 5.5e-59 199.4 0.9 5.5e-59 199.4 0.9 2.1 2 0 0 2 2 1 1 DNA replication factor Dna2 AAA_12 PF13087.6 EDO19220.1 - 1.3e-48 165.3 0.5 2.7e-48 164.2 0.5 1.6 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 EDO19220.1 - 1.4e-34 120.1 11.3 9.1e-19 68.3 0.0 3.6 2 2 1 3 3 2 2 AAA domain AAA_30 PF13604.6 EDO19220.1 - 3.6e-13 49.6 0.0 7.4e-13 48.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EDO19220.1 - 1.5e-11 44.9 0.0 3.6e-11 43.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 EDO19220.1 - 1.4e-06 28.2 0.1 0.043 13.5 0.0 3.7 3 0 0 3 3 3 1 Viral (Superfamily 1) RNA helicase PDDEXK_1 PF12705.7 EDO19220.1 - 2.6e-06 27.6 0.0 6.1e-06 26.3 0.0 1.7 1 0 0 1 1 1 1 PD-(D/E)XK nuclease superfamily Helicase_RecD PF05127.14 EDO19220.1 - 0.00056 19.8 0.0 0.0013 18.6 0.0 1.6 1 0 0 1 1 1 1 Helicase Csa1 PF06023.12 EDO19220.1 - 0.00063 19.2 0.1 0.0014 18.1 0.1 1.5 1 0 0 1 1 1 1 CRISPR-associated exonuclease Csa1 Cas_Cas4 PF01930.17 EDO19220.1 - 0.0018 18.4 0.2 0.08 13.0 0.0 3.2 3 0 0 3 3 3 1 Domain of unknown function DUF83 SRP54 PF00448.22 EDO19220.1 - 0.0061 16.2 0.0 0.024 14.3 0.0 2.0 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain AAA_33 PF13671.6 EDO19220.1 - 0.0061 16.7 0.0 0.79 9.9 0.0 3.1 3 0 0 3 3 3 1 AAA domain ResIII PF04851.15 EDO19220.1 - 0.0066 16.5 0.2 0.0066 16.5 0.2 3.0 3 1 0 3 3 3 1 Type III restriction enzyme, res subunit AAA_5 PF07728.14 EDO19220.1 - 0.016 15.2 0.0 0.065 13.2 0.1 2.0 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) UvrD-helicase PF00580.21 EDO19220.1 - 0.018 14.6 0.1 0.018 14.6 0.1 2.9 2 2 0 2 2 1 0 UvrD/REP helicase N-terminal domain AAA_16 PF13191.6 EDO19220.1 - 0.034 14.5 0.0 0.09 13.2 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain AAA PF00004.29 EDO19220.1 - 0.058 13.8 0.0 0.25 11.8 0.0 2.2 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 EDO19220.1 - 0.11 12.2 0.1 0.72 9.6 0.0 2.2 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain AAA_29 PF13555.6 EDO19220.1 - 0.12 12.2 0.0 0.29 10.9 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_18 PF13238.6 EDO19220.1 - 0.12 12.9 2.4 0.16 12.5 0.0 2.5 2 1 0 2 2 1 0 AAA domain ABC_tran PF00005.27 EDO19220.1 - 0.14 12.6 1.3 1.2 9.6 0.0 2.8 2 0 0 2 2 2 0 ABC transporter AAA_14 PF13173.6 EDO19220.1 - 1 9.4 6.5 0.24 11.4 0.1 3.3 3 1 1 4 4 3 0 AAA domain PROCN PF08083.11 EDO19221.1 - 8.6e-221 732.8 14.4 1.3e-220 732.2 14.4 1.3 1 0 0 1 1 1 1 PROCN (NUC071) domain PRP8_domainIV PF12134.8 EDO19221.1 - 7.5e-123 408.5 1.4 1.8e-122 407.3 1.4 1.7 1 0 0 1 1 1 1 PRP8 domain IV core U6-snRNA_bdg PF10596.9 EDO19221.1 - 8.1e-84 279.4 1.7 8.1e-84 279.4 1.7 2.3 2 0 0 2 2 2 1 U6-snRNA interacting domain of PrP8 PRO8NT PF08082.11 EDO19221.1 - 1.3e-81 271.9 3.8 2.8e-81 270.8 3.8 1.6 1 0 0 1 1 1 1 PRO8NT (NUC069), PrP8 N-terminal domain U5_2-snRNA_bdg PF10597.9 EDO19221.1 - 3.6e-70 234.3 0.0 9.3e-70 232.9 0.0 1.8 1 0 0 1 1 1 1 U5-snRNA binding site 2 of PrP8 RRM_4 PF10598.9 EDO19221.1 - 2.5e-45 152.7 0.3 6.5e-45 151.4 0.3 1.8 1 0 0 1 1 1 1 RNA recognition motif of the spliceosomal PrP8 PROCT PF08084.11 EDO19221.1 - 1.3e-44 151.1 0.1 3.3e-44 149.7 0.1 1.8 1 0 0 1 1 1 1 PROCT (NUC072) domain JAB PF01398.21 EDO19221.1 - 0.003 17.5 0.1 0.057 13.4 0.0 2.8 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Endonuclease_NS PF01223.23 EDO19221.1 - 0.026 14.4 4.0 0.73 9.6 0.6 2.8 2 0 0 2 2 2 0 DNA/RNA non-specific endonuclease ANAPC8 PF04049.13 EDO19222.1 - 2.5e-37 128.0 0.2 7.1e-37 126.6 0.0 1.9 2 0 0 2 2 2 1 Anaphase promoting complex subunit 8 / Cdc23 TPR_1 PF00515.28 EDO19222.1 - 6.5e-21 73.2 27.2 4.7e-06 26.2 0.0 8.5 9 0 0 9 9 9 4 Tetratricopeptide repeat TPR_8 PF13181.6 EDO19222.1 - 1.2e-20 71.9 28.2 4e-05 23.5 0.0 9.8 10 2 1 11 11 10 5 Tetratricopeptide repeat TPR_2 PF07719.17 EDO19222.1 - 2.2e-19 68.0 24.6 0.0042 17.1 0.0 9.1 9 1 0 9 9 9 5 Tetratricopeptide repeat TPR_14 PF13428.6 EDO19222.1 - 2.9e-15 55.7 9.3 0.00058 20.5 0.0 6.3 6 1 1 7 7 6 3 Tetratricopeptide repeat TPR_11 PF13414.6 EDO19222.1 - 2.7e-13 49.4 5.1 4.7e-09 35.8 0.1 4.7 3 2 2 5 5 5 3 TPR repeat TPR_16 PF13432.6 EDO19222.1 - 2e-11 44.4 4.0 1.1e-06 29.1 0.0 4.7 4 1 0 5 5 4 2 Tetratricopeptide repeat TPR_17 PF13431.6 EDO19222.1 - 2.5e-08 33.7 14.7 0.0044 17.3 0.0 6.8 7 0 0 7 7 6 2 Tetratricopeptide repeat TPR_12 PF13424.6 EDO19222.1 - 3.4e-07 30.5 16.8 0.0024 18.1 0.7 5.4 4 2 0 5 5 5 2 Tetratricopeptide repeat ChAPs PF09295.10 EDO19222.1 - 1e-06 28.0 0.3 5.8e-05 22.3 0.0 2.2 1 1 1 2 2 2 1 ChAPs (Chs5p-Arf1p-binding proteins) TPR_7 PF13176.6 EDO19222.1 - 1.3e-06 28.0 8.6 0.038 14.0 0.1 5.1 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 EDO19222.1 - 1.3e-05 25.6 6.3 0.39 11.3 0.0 5.7 5 1 1 6 6 5 2 Tetratricopeptide repeat RPN7 PF10602.9 EDO19222.1 - 3.7e-05 23.5 7.1 8.1e-05 22.4 0.9 3.2 4 0 0 4 4 4 1 26S proteasome subunit RPN7 TPR_15 PF13429.6 EDO19222.1 - 8e-05 22.0 4.2 0.36 10.0 0.1 3.7 1 1 1 2 2 2 2 Tetratricopeptide repeat BTAD PF03704.17 EDO19222.1 - 0.0009 19.7 0.2 0.004 17.6 0.1 2.0 1 1 1 2 2 2 1 Bacterial transcriptional activator domain TPR_9 PF13371.6 EDO19222.1 - 0.0011 19.1 0.2 1.5 9.1 0.0 2.9 1 1 2 3 3 3 3 Tetratricopeptide repeat ANAPC3 PF12895.7 EDO19222.1 - 0.0067 16.6 23.6 0.15 12.3 0.3 6.0 3 1 4 8 8 8 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_10 PF13374.6 EDO19222.1 - 0.14 12.1 8.2 2.8 7.9 0.1 5.2 5 0 0 5 5 5 0 Tetratricopeptide repeat DUF1765 PF08578.10 EDO19222.1 - 0.25 11.8 4.8 3.6 8.1 1.3 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1765) TPR_6 PF13174.6 EDO19222.1 - 1.4 9.7 18.0 42 5.1 0.0 7.7 8 1 0 8 8 8 0 Tetratricopeptide repeat MIT PF04212.18 EDO19222.1 - 3.8 7.6 7.0 22 5.2 0.0 4.3 4 0 0 4 4 4 0 MIT (microtubule interacting and transport) domain THP2 PF09432.10 EDO19223.1 - 6.7e-50 168.5 6.2 6.7e-50 168.5 6.2 1.9 2 0 0 2 2 2 1 Tho complex subunit THP2 GTP1_OBG PF01018.22 EDO19224.1 - 4.3e-37 127.1 1.1 3e-27 95.1 1.4 2.2 2 0 0 2 2 2 2 GTP1/OBG MMR_HSR1 PF01926.23 EDO19224.1 - 2.9e-22 78.9 0.0 4.9e-22 78.2 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EDO19224.1 - 2.6e-10 40.1 0.0 4e-10 39.4 0.0 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B Arf PF00025.21 EDO19224.1 - 3.9e-09 36.2 0.0 8.5e-09 35.1 0.0 1.5 1 1 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 EDO19224.1 - 0.00037 20.1 0.0 0.0012 18.4 0.0 1.9 1 1 0 1 1 1 1 Ras family GTP_EFTU PF00009.27 EDO19224.1 - 0.0034 16.9 0.0 0.15 11.6 0.0 2.3 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 EDO19224.1 - 0.041 13.9 0.1 4.9 7.2 0.1 2.4 1 1 1 2 2 2 0 Dynamin family SRPRB PF09439.10 EDO19224.1 - 0.047 13.1 0.5 8.7 5.7 0.2 2.2 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit MeaB PF03308.16 EDO19224.1 - 0.053 12.5 0.1 1.5 7.7 0.0 2.1 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AIG1 PF04548.16 EDO19224.1 - 0.053 12.8 0.0 0.088 12.1 0.0 1.3 1 0 0 1 1 1 0 AIG1 family RsgA_GTPase PF03193.16 EDO19224.1 - 0.13 12.2 0.1 11 5.9 0.0 2.3 2 0 0 2 2 2 0 RsgA GTPase MMR_HSR1_Xtn PF16897.5 EDO19224.1 - 0.18 11.9 0.4 0.44 10.6 0.4 1.6 1 1 0 1 1 1 0 C-terminal region of MMR_HSR1 domain NOP19 PF10863.8 EDO19225.1 - 1.5e-54 183.7 8.6 2.5e-54 182.9 8.6 1.3 1 0 0 1 1 1 1 Nucleolar protein 19 DUF4661 PF15576.6 EDO19225.1 - 0.096 12.6 3.5 0.27 11.1 2.8 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4661) Carbpep_Y_N PF05388.11 EDO19225.1 - 1.3 9.5 7.8 0.29 11.7 0.4 2.8 2 1 1 3 3 3 0 Carboxypeptidase Y pro-peptide ThiF PF00899.21 EDO19226.1 - 1.9e-46 158.4 0.0 3.2e-46 157.7 0.0 1.2 1 0 0 1 1 1 1 ThiF family ATG7_N PF16420.5 EDO19226.1 - 4.2e-46 158.0 9.3 6.9e-46 157.3 9.3 1.4 1 0 0 1 1 1 1 Ubiquitin-like modifier-activating enzyme ATG7 N-terminus Shikimate_DH PF01488.20 EDO19226.1 - 0.01 15.9 0.0 0.066 13.3 0.0 2.1 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase Toprim PF01751.22 EDO19226.1 - 0.068 13.4 0.1 0.34 11.1 0.1 2.1 2 0 0 2 2 2 0 Toprim domain ApbA PF02558.16 EDO19226.1 - 0.11 12.2 0.0 0.2 11.3 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA 2-Hacid_dh_C PF02826.19 EDO19226.1 - 0.17 11.2 0.0 1.7 8.0 0.0 2.1 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Enolase_C PF00113.22 EDO19227.1 - 4.3e-150 498.9 0.0 6.5e-150 498.3 0.0 1.2 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.16 EDO19227.1 - 5.4e-59 198.1 0.5 8.6e-59 197.4 0.5 1.3 1 0 0 1 1 1 1 Enolase, N-terminal domain MR_MLE_C PF13378.6 EDO19227.1 - 4.7e-07 29.6 0.0 8.5e-07 28.8 0.0 1.4 1 0 0 1 1 1 1 Enolase C-terminal domain-like MAAL_C PF07476.11 EDO19227.1 - 0.018 14.2 0.3 0.055 12.6 0.1 1.8 2 0 0 2 2 2 0 Methylaspartate ammonia-lyase C-terminus Transposon_TraM PF12508.8 EDO19227.1 - 0.13 12.0 0.1 0.22 11.2 0.1 1.3 1 0 0 1 1 1 0 Conjugative transposon, TraM Peptidase_M16 PF00675.20 EDO19228.1 - 1.4e-30 106.3 0.0 2.7e-30 105.3 0.0 1.5 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_M PF16187.5 EDO19228.1 - 1.3e-15 57.5 0.2 2.1e-15 56.8 0.2 1.4 1 0 0 1 1 1 1 Middle or third domain of peptidase_M16 Peptidase_M16_C PF05193.21 EDO19228.1 - 2.2e-09 37.6 0.1 0.0056 16.7 0.1 3.8 4 0 0 4 4 4 2 Peptidase M16 inactive domain DUF2378 PF09536.10 EDO19228.1 - 0.18 11.7 0.0 0.32 10.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2378) Acetyltransf_7 PF13508.7 EDO19229.1 - 0.00071 19.9 0.0 0.002 18.5 0.0 1.8 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EDO19229.1 - 0.0011 19.2 0.0 0.007 16.6 0.0 2.1 2 1 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_9 PF13527.7 EDO19229.1 - 0.002 18.2 0.0 0.0084 16.2 0.0 2.0 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EDO19229.1 - 0.0093 15.9 0.0 0.021 14.8 0.0 1.6 1 0 0 1 1 1 1 FR47-like protein LMSTEN PF07988.12 EDO19229.1 - 0.016 14.7 0.2 0.12 11.9 0.0 2.3 2 0 0 2 2 2 0 LMSTEN motif SURF1 PF02104.15 EDO19230.1 - 3.3e-43 148.0 0.1 4.5e-43 147.5 0.1 1.1 1 0 0 1 1 1 1 SURF1 family DUF5634 PF18681.1 EDO19230.1 - 0.045 14.1 0.0 0.09 13.2 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5634) DASH_Dam1 PF08653.10 EDO19231.1 - 1.2e-24 85.9 0.1 2.5e-24 84.8 0.1 1.6 1 0 0 1 1 1 1 DASH complex subunit Dam1 MRFAP1 PF15155.6 EDO19231.1 - 0.04 14.4 0.6 0.26 11.8 0.4 2.2 2 0 0 2 2 2 0 MORF4 family-associated protein1 Phage_pRha PF09669.10 EDO19231.1 - 0.39 11.3 1.8 0.87 10.2 0.1 2.4 2 1 0 2 2 2 0 Phage regulatory protein Rha (Phage_pRha) Ctr PF04145.15 EDO19232.1 - 9.9e-20 71.7 1.6 9.9e-20 71.7 1.6 2.2 3 0 0 3 3 3 1 Ctr copper transporter family Comm PF15957.5 EDO19232.1 - 0.093 13.1 0.3 2.9 8.3 0.0 2.5 2 0 0 2 2 2 0 Commissureless SH2_2 PF14633.6 EDO19233.1 - 7.1e-68 228.2 1.4 7.1e-68 228.2 1.4 2.1 2 0 0 2 2 2 1 SH2 domain YqgF PF14639.6 EDO19233.1 - 1.3e-62 210.0 0.0 5.9e-62 207.9 0.0 2.2 1 0 0 1 1 1 1 Holliday-junction resolvase-like of SPT6 HHH_7 PF14635.6 EDO19233.1 - 5.4e-43 145.6 0.1 1.5e-42 144.2 0.1 1.8 1 0 0 1 1 1 1 Helix-hairpin-helix motif HTH_44 PF14641.6 EDO19233.1 - 8.9e-36 122.8 1.7 4.4e-35 120.6 1.7 2.3 1 0 0 1 1 1 1 Helix-turn-helix DNA-binding domain of SPT6 SPT6_acidic PF14632.6 EDO19233.1 - 3.2e-20 72.5 20.6 3.2e-20 72.5 20.6 6.4 5 2 2 7 7 7 1 Acidic N-terminal SPT6 SH2 PF00017.24 EDO19233.1 - 1.4e-12 47.5 0.0 5.8e-12 45.5 0.0 2.2 1 0 0 1 1 1 1 SH2 domain HHH_9 PF17674.1 EDO19233.1 - 0.00025 21.9 3.3 0.0016 19.3 1.5 3.5 2 1 0 2 2 2 1 HHH domain Tex_YqgF PF16921.5 EDO19233.1 - 0.11 12.9 0.0 0.27 11.7 0.0 1.6 1 0 0 1 1 1 0 Tex protein YqgF-like domain LETM1 PF07766.13 EDO19234.1 - 2.4e-93 312.3 2.3 3.9e-93 311.7 2.3 1.3 1 0 0 1 1 1 1 LETM1-like protein Mito_carr PF00153.27 EDO19235.1 - 3.7e-55 183.8 4.8 3.9e-19 68.4 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein BTB PF00651.31 EDO19235.1 - 0.044 14.0 0.1 0.64 10.3 0.0 2.3 2 0 0 2 2 2 0 BTB/POZ domain Ribosom_S12_S23 PF00164.25 EDO19236.1 - 3.3e-51 171.7 0.3 4.2e-51 171.4 0.3 1.1 1 0 0 1 1 1 1 Ribosomal protein S12/S23 Nup54 PF13874.6 EDO19237.1 - 4e-35 121.0 4.5 4e-35 121.0 4.5 2.6 2 0 0 2 2 2 1 Nucleoporin complex subunit 54 Nucleoporin_FG PF13634.6 EDO19237.1 - 2.6e-16 60.2 135.1 6.7e-10 39.7 35.4 5.4 1 1 4 5 5 5 3 Nucleoporin FG repeat region TFIIA PF03153.13 EDO19237.1 - 0.013 15.6 26.6 0.005 16.9 15.4 2.4 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit DUF807 PF05660.11 EDO19237.1 - 0.021 14.8 0.1 0.042 13.8 0.1 1.4 1 0 0 1 1 1 0 Coxiella burnetii protein of unknown function (DUF807) COG2 PF06148.11 EDO19238.1 - 1.1e-06 28.8 10.7 1.3e-06 28.5 8.3 2.2 1 1 1 2 2 2 1 COG (conserved oligomeric Golgi) complex component, COG2 Copine PF07002.16 EDO19238.1 - 0.012 15.1 0.0 0.028 13.9 0.0 1.5 1 0 0 1 1 1 0 Copine DHDPS PF00701.22 EDO19238.1 - 0.019 13.7 0.0 0.031 13.0 0.0 1.3 1 0 0 1 1 1 0 Dihydrodipicolinate synthetase family Syntaxin_2 PF14523.6 EDO19238.1 - 0.027 14.8 8.5 0.12 12.7 2.1 3.3 1 1 1 3 3 3 0 Syntaxin-like protein NusB PF01029.18 EDO19238.1 - 0.027 14.7 1.0 0.051 13.8 0.9 1.6 1 1 0 1 1 1 0 NusB family SesA PF17107.5 EDO19238.1 - 0.042 14.0 0.7 0.12 12.5 0.3 1.9 2 0 0 2 2 2 0 N-terminal domain on NACHT_NTPase and P-loop NTPases LOH1CR12 PF10158.9 EDO19238.1 - 0.07 13.1 2.9 0.82 9.7 0.6 2.7 1 1 2 3 3 3 0 Tumour suppressor protein DUF445 PF04286.12 EDO19238.1 - 0.084 12.7 1.8 0.11 12.3 1.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF445) COX5A PF02284.16 EDO19238.1 - 0.085 12.9 0.8 0.41 10.7 0.1 2.2 1 1 1 2 2 2 0 Cytochrome c oxidase subunit Va Nse4-Nse3_bdg PF15412.6 EDO19238.1 - 0.1 12.7 3.6 5.3 7.2 0.1 3.3 3 1 0 3 3 3 0 Binding domain of Nse4/EID3 to Nse3-MAGE DUF4208 PF13907.6 EDO19238.1 - 0.12 12.8 0.6 0.27 11.7 0.6 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4208) Spectrin PF00435.21 EDO19238.1 - 0.14 12.7 3.0 1.7 9.2 2.1 2.6 1 1 1 2 2 2 0 Spectrin repeat AATF-Che1 PF13339.6 EDO19238.1 - 0.28 11.9 1.8 13 6.5 1.8 2.5 1 1 0 1 1 1 0 Apoptosis antagonizing transcription factor Sec5 PF15469.6 EDO19238.1 - 0.4 10.5 5.5 0.63 9.8 3.4 2.3 1 1 1 2 2 2 0 Exocyst complex component Sec5 DUF948 PF06103.11 EDO19238.1 - 0.59 10.4 3.6 9.5 6.6 0.5 3.2 2 1 0 3 3 3 0 Bacterial protein of unknown function (DUF948) Occludin_ELL PF07303.13 EDO19238.1 - 1.3 9.8 4.1 5.4 7.8 2.5 2.6 1 1 3 4 4 4 0 Occludin homology domain Mcl1_mid PF12341.8 EDO19239.1 - 7e-88 294.8 0.0 1.8e-87 293.5 0.0 1.7 1 0 0 1 1 1 1 Minichromosome loss protein, Mcl1, middle region ANAPC4_WD40 PF12894.7 EDO19239.1 - 0.00017 21.8 0.5 3.6 7.9 0.1 4.5 3 1 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EDO19239.1 - 0.00068 19.1 0.3 0.57 9.5 0.0 2.5 2 1 0 2 2 2 2 WD40-like domain WD40 PF00400.32 EDO19240.1 - 6e-16 58.6 2.9 4.9e-05 24.0 0.0 5.5 5 0 0 5 5 5 4 WD domain, G-beta repeat WD40_like PF17005.5 EDO19240.1 - 0.077 12.3 1.0 0.8 9.0 0.0 2.8 4 0 0 4 4 4 0 WD40-like domain ANAPC4_WD40 PF12894.7 EDO19240.1 - 0.093 13.0 0.0 1.1 9.6 0.0 2.4 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain Ammonium_transp PF00909.21 EDO19241.1 - 1.2e-119 399.6 23.1 1.4e-119 399.4 23.1 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family Phage_holin_2_1 PF04971.12 EDO19241.1 - 0.085 12.9 2.0 0.65 10.0 0.3 3.1 2 0 0 2 2 2 0 Bacteriophage P21 holin S Slp PF03843.13 EDO19241.1 - 0.13 11.7 0.0 0.21 11.0 0.0 1.2 1 0 0 1 1 1 0 Outer membrane lipoprotein Slp family DUF4791 PF16039.5 EDO19241.1 - 0.54 9.8 2.9 0.28 10.7 0.3 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4791) Stevor PF17410.2 EDO19242.1 - 0.0032 17.1 2.3 0.0043 16.6 2.3 1.2 1 0 0 1 1 1 1 Subtelomeric Variable Open Reading frame Orf78 PF06024.12 EDO19242.1 - 0.019 15.2 0.3 0.019 15.2 0.3 1.6 2 0 0 2 2 2 0 Orf78 (ac78) SLC3A2_N PF16028.5 EDO19242.1 - 2.3 7.8 4.1 6 6.5 4.1 1.6 1 0 0 1 1 1 0 Solute carrier family 3 member 2 N-terminus Kinesin PF00225.23 EDO19243.1 - 8.3e-91 304.4 3.5 8.3e-91 304.4 3.5 2.5 2 1 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 EDO19243.1 - 2.1e-51 173.8 0.2 2.1e-51 173.8 0.2 3.6 2 1 2 4 4 4 1 Microtubule binding DERM PF14704.6 EDO19243.1 - 0.0058 17.1 1.2 0.015 15.8 1.2 1.7 1 0 0 1 1 1 1 Dermatopontin Abi_C PF14355.6 EDO19243.1 - 3 8.0 5.1 3.1 8.0 0.1 3.3 3 0 0 3 3 3 0 Abortive infection C-terminus PWWP PF00855.17 EDO19244.1 - 3.1e-06 27.5 0.2 3.1e-06 27.5 0.2 1.0 1 0 0 1 1 1 1 PWWP domain PWWP PF00855.17 EDO19245.1 - 9.8e-05 22.7 0.1 0.00057 20.2 0.0 2.2 2 0 0 2 2 2 1 PWWP domain ThiF PF00899.21 EDO19246.1 - 3.4e-28 98.6 0.0 4.8e-28 98.2 0.0 1.2 1 0 0 1 1 1 1 ThiF family Sec23_trunk PF04811.15 EDO19247.1 - 1.6e-71 240.7 0.0 2.2e-71 240.3 0.0 1.2 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_BS PF08033.12 EDO19247.1 - 3.2e-30 104.7 0.2 8e-30 103.4 0.2 1.7 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain Sec23_helical PF04815.15 EDO19247.1 - 1.4e-26 92.3 0.0 3.4e-26 91.0 0.0 1.7 1 0 0 1 1 1 1 Sec23/Sec24 helical domain zf-Sec23_Sec24 PF04810.15 EDO19247.1 - 7.6e-12 45.1 9.0 7.6e-12 45.1 9.0 2.0 2 0 0 2 2 2 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 EDO19247.1 - 1.4e-11 44.1 0.0 2.7e-11 43.2 0.0 1.5 1 0 0 1 1 1 1 Gelsolin repeat Vps36-NZF-N PF16988.5 EDO19247.1 - 0.00047 19.5 2.1 0.0012 18.2 2.1 1.6 1 0 0 1 1 1 1 Vacuolar protein sorting 36 NZF-N zinc-finger domain tRNA-synt_1g PF09334.11 EDO19247.1 - 0.049 12.4 0.1 0.084 11.6 0.1 1.3 1 0 0 1 1 1 0 tRNA synthetases class I (M) zf-MIZ PF02891.20 EDO19247.1 - 0.12 12.1 2.1 0.26 11.1 2.1 1.5 1 0 0 1 1 1 0 MIZ/SP-RING zinc finger PIG-U PF06728.13 EDO19248.1 - 1.4e-101 340.3 49.0 1.7e-101 340.0 49.0 1.1 1 0 0 1 1 1 1 GPI transamidase subunit PIG-U zf-C2H2 PF00096.26 EDO19249.1 - 4.1e-29 99.4 61.0 0.0014 19.0 0.5 9.3 9 0 0 9 9 9 9 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EDO19249.1 - 6.3e-22 76.4 61.2 0.006 17.3 4.1 9.2 9 0 0 9 9 9 9 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EDO19249.1 - 8.8e-16 57.5 50.2 8.9e-05 22.7 1.0 9.5 9 0 0 9 9 9 6 Zinc-finger double domain zf-C2H2_jaz PF12171.8 EDO19249.1 - 2.4e-09 37.2 33.5 0.037 14.3 0.1 7.8 8 0 0 8 8 8 5 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EDO19249.1 - 6.9e-06 26.3 32.1 0.005 17.2 0.2 8.2 8 0 0 8 8 8 2 Zinc-finger of C2H2 type zf-C2H2_8 PF15909.5 EDO19249.1 - 0.0027 18.0 24.6 0.19 12.1 3.2 5.1 2 1 3 5 5 5 2 C2H2-type zinc ribbon CpXC PF14353.6 EDO19249.1 - 0.028 14.5 0.2 0.028 14.5 0.2 4.1 3 2 2 5 5 5 0 CpXC protein zf-C2H2_6 PF13912.6 EDO19249.1 - 0.2 11.7 0.1 0.2 11.7 0.1 7.3 9 0 0 9 9 9 0 C2H2-type zinc finger Ogr_Delta PF04606.12 EDO19249.1 - 1.3 9.0 7.8 26 4.9 0.1 4.1 3 0 0 3 3 3 0 Ogr/Delta-like zinc finger FOXP-CC PF16159.5 EDO19249.1 - 2.9 8.6 23.1 14 6.4 1.1 5.8 3 2 3 6 6 6 0 FOXP coiled-coil domain RNA_pol_Rpb6 PF01192.22 EDO19250.1 - 3.3e-17 62.2 0.1 4.7e-17 61.6 0.1 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb6 EF-hand_6 PF13405.6 EDO19251.1 - 2.5e-10 39.4 2.4 1.1e-06 28.1 1.0 3.3 3 1 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.6 EDO19251.1 - 7e-09 36.0 1.4 5.6e-08 33.1 1.4 2.4 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 EDO19251.1 - 2.1e-08 33.1 2.8 4.6e-06 25.8 0.5 3.7 3 0 0 3 3 3 1 EF hand EF-hand_5 PF13202.6 EDO19251.1 - 1.2e-06 27.7 5.7 6.3e-06 25.4 0.7 3.4 4 0 0 4 4 4 1 EF hand EF-hand_8 PF13833.6 EDO19251.1 - 0.0066 16.3 5.2 0.012 15.5 0.1 3.1 3 1 0 3 3 3 1 EF-hand domain pair DUF1456 PF07308.13 EDO19251.1 - 0.2 12.0 0.8 4.7 7.6 0.3 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF1456) TPR_22 PF18833.1 EDO19252.1 - 1e-41 141.0 0.6 3.4e-41 139.3 0.6 2.0 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_19 PF14559.6 EDO19252.1 - 1.5e-23 83.1 0.0 5e-06 26.9 0.0 8.6 6 3 2 8 8 8 6 Tetratricopeptide repeat TPR_2 PF07719.17 EDO19252.1 - 8.1e-23 78.6 5.1 0.00014 21.7 0.0 12.4 14 0 0 14 14 12 3 Tetratricopeptide repeat TPR_1 PF00515.28 EDO19252.1 - 1.9e-20 71.8 0.8 0.00012 21.8 0.0 11.3 12 0 0 12 12 11 3 Tetratricopeptide repeat TPR_11 PF13414.6 EDO19252.1 - 2.6e-20 71.8 0.0 0.00017 21.2 0.0 7.2 6 1 1 7 7 6 5 TPR repeat TPR_14 PF13428.6 EDO19252.1 - 9e-17 60.4 0.1 0.0085 16.8 0.0 10.2 7 3 5 12 12 11 2 Tetratricopeptide repeat TPR_17 PF13431.6 EDO19252.1 - 4.5e-16 58.0 2.5 0.023 15.0 0.0 8.6 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_16 PF13432.6 EDO19252.1 - 4.6e-14 52.8 0.0 0.0024 18.5 0.0 7.0 5 3 2 7 7 6 2 Tetratricopeptide repeat TPR_12 PF13424.6 EDO19252.1 - 7e-14 51.9 5.2 0.18 12.1 0.1 9.1 9 2 2 11 11 10 5 Tetratricopeptide repeat TPR_8 PF13181.6 EDO19252.1 - 4.7e-12 45.1 24.3 4.5e-06 26.5 0.0 10.9 13 2 0 13 13 10 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EDO19252.1 - 1.1e-10 41.6 6.7 0.00037 20.7 0.0 6.2 6 0 0 6 6 6 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 EDO19252.1 - 1.9e-10 40.7 0.2 0.3 11.8 0.0 8.7 10 0 0 10 10 8 1 Tetratricopeptide repeat TPR_7 PF13176.6 EDO19252.1 - 6.2e-10 38.4 0.8 0.25 11.4 0.0 8.7 9 0 0 9 9 9 1 Tetratricopeptide repeat Alkyl_sulf_dimr PF14863.6 EDO19252.1 - 3e-05 24.5 0.4 0.21 12.1 0.1 3.6 3 0 0 3 3 3 2 Alkyl sulfatase dimerisation TPR_10 PF13374.6 EDO19252.1 - 0.00018 21.2 0.2 7.6 6.6 0.1 5.4 7 0 0 7 7 7 1 Tetratricopeptide repeat DUF627 PF04781.12 EDO19252.1 - 0.00033 20.6 3.3 4.6 7.3 0.0 4.8 4 1 1 5 5 5 1 Protein of unknown function (DUF627) HrpB1_HrpK PF09613.10 EDO19252.1 - 0.0043 16.7 0.0 8.9 6.0 0.0 3.6 3 0 0 3 3 3 0 Bacterial type III secretion protein (HrpB1_HrpK) NARP1 PF12569.8 EDO19252.1 - 0.015 14.2 8.4 0.47 9.3 0.0 4.0 4 1 1 5 5 5 0 NMDA receptor-regulated protein 1 TPR_9 PF13371.6 EDO19252.1 - 0.028 14.6 0.1 0.2 11.8 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_4 PF07721.14 EDO19252.1 - 0.21 12.3 0.0 87 4.2 0.0 4.0 5 0 0 5 5 4 0 Tetratricopeptide repeat MIT PF04212.18 EDO19252.1 - 9.9 6.3 9.3 18 5.5 0.2 5.4 7 0 0 7 7 6 0 MIT (microtubule interacting and transport) domain TPR_2 PF07719.17 EDO19253.1 - 0.00039 20.3 0.1 0.0043 17.1 0.0 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 EDO19253.1 - 0.00071 19.8 0.1 0.062 13.6 0.0 2.2 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 EDO19253.1 - 0.0083 16.3 0.1 2.3 8.6 0.0 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 EDO19253.1 - 0.026 14.3 0.1 0.2 11.6 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat RNA_pol_Rpc82 PF05645.13 EDO19254.1 - 2.5e-71 240.5 1.0 3.2e-71 240.1 0.4 1.5 2 0 0 2 2 2 1 RNA polymerase III subunit RPC82 HTH_9 PF08221.11 EDO19254.1 - 2.6e-23 81.9 2.2 7.6e-18 64.4 0.1 3.6 3 0 0 3 3 3 2 RNA polymerase III subunit RPC82 helix-turn-helix domain TFIIE_alpha PF02002.17 EDO19254.1 - 2.3e-07 30.6 2.0 0.0037 17.1 0.1 3.0 2 1 0 2 2 2 2 TFIIE alpha subunit Rio2_N PF09202.11 EDO19254.1 - 0.56 10.5 3.9 2.2 8.5 0.2 3.2 3 0 0 3 3 3 0 Rio2, N-terminal TSC22 PF01166.18 EDO19254.1 - 0.65 10.4 3.1 0.65 10.4 0.3 2.4 2 0 0 2 2 2 0 TSC-22/dip/bun family Peptidase_M16 PF00675.20 EDO19255.1 - 3.7e-23 82.1 0.0 6.7e-23 81.3 0.0 1.4 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 EDO19255.1 - 5.5e-08 33.0 0.4 5.2e-07 29.9 0.2 2.5 2 1 0 2 2 2 1 Peptidase M16 inactive domain FAD_binding_6 PF00970.24 EDO19255.1 - 0.052 13.9 0.2 0.22 11.9 0.2 2.1 1 1 0 1 1 1 0 Oxidoreductase FAD-binding domain zf-H2C2_2 PF13465.6 EDO19256.1 - 2.3e-05 24.6 6.1 2.3e-05 24.6 6.1 4.2 5 0 0 5 5 5 1 Zinc-finger double domain zf-C2H2 PF00096.26 EDO19256.1 - 0.00032 21.0 17.1 0.00073 19.9 1.9 3.0 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-met PF12874.7 EDO19256.1 - 0.0012 19.2 6.2 0.017 15.5 0.3 2.8 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.6 EDO19256.1 - 0.0097 16.7 1.1 0.0097 16.7 1.1 3.3 3 0 0 3 3 3 2 C2H2-type zinc finger Flocculin PF00624.18 EDO19257.1 - 1.6e-206 668.3 950.3 6e-13 48.8 30.5 26.2 26 0 0 26 26 26 25 Flocculin repeat GLEYA PF10528.9 EDO19257.1 - 2e-24 85.8 0.4 1.4e-21 76.7 0.4 6.3 1 0 0 1 1 1 1 GLEYA domain PA14 PF07691.12 EDO19257.1 - 1.1e-16 60.9 0.0 1.1e-16 60.9 0.0 9.9 10 6 8 18 18 18 1 PA14 domain Secapin PF17521.2 EDO19257.1 - 7.7e-11 41.6 29.8 1.2e+02 2.6 0.0 18.6 21 0 0 21 21 21 0 Honey bee peptides DndE PF08870.11 EDO19257.1 - 0.0042 17.3 0.0 1.2e+02 3.0 0.0 8.6 23 1 1 24 24 24 0 DNA sulphur modification protein DndE DUF5314 PF17241.2 EDO19258.1 - 2.4e-71 239.5 0.5 2.8e-71 239.3 0.5 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5314) ICL PF00463.21 EDO19259.1 - 8.1e-277 918.9 0.6 9.3e-277 918.7 0.6 1.0 1 0 0 1 1 1 1 Isocitrate lyase family PEP_mutase PF13714.6 EDO19259.1 - 7.2e-10 38.7 0.0 1.2e-09 38.0 0.0 1.3 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase Terpene_synth_C PF03936.16 EDO19259.1 - 0.12 11.7 0.8 0.27 10.5 0.8 1.5 1 0 0 1 1 1 0 Terpene synthase family, metal binding domain Atg31 PF09795.9 EDO19260.1 - 3.4e-53 179.8 5.2 4e-53 179.6 5.2 1.0 1 0 0 1 1 1 1 Autophagy-related protein 31 DEAD PF00270.29 EDO19261.1 - 1.9e-42 145.0 1.6 3.4e-42 144.2 1.6 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDO19261.1 - 1.5e-32 112.2 0.3 6.7e-31 106.9 0.0 3.0 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDO19261.1 - 4.4e-06 26.8 0.1 9.4e-06 25.7 0.0 1.5 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 EDO19261.1 - 4.4e-05 23.3 0.1 8.9e-05 22.3 0.1 1.5 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EDO19261.1 - 0.00021 21.6 0.2 0.0009 19.6 0.1 1.9 2 0 0 2 2 2 1 AAA domain Helicase_RecD PF05127.14 EDO19261.1 - 0.006 16.4 0.0 0.014 15.3 0.0 1.5 1 0 0 1 1 1 1 Helicase AAA_22 PF13401.6 EDO19261.1 - 0.0071 16.6 0.6 0.022 15.0 0.6 1.8 1 1 0 1 1 1 1 AAA domain CMS1 PF14617.6 EDO19261.1 - 0.017 14.5 0.0 0.059 12.7 0.0 1.8 2 0 0 2 2 2 0 U3-containing 90S pre-ribosomal complex subunit Flavi_DEAD PF07652.14 EDO19261.1 - 0.021 14.8 0.0 0.09 12.8 0.0 2.0 1 1 0 1 1 1 0 Flavivirus DEAD domain UvrD-helicase PF00580.21 EDO19261.1 - 0.046 13.2 0.1 0.056 13.0 0.1 1.2 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain TniB PF05621.11 EDO19261.1 - 0.097 12.1 0.0 0.2 11.1 0.0 1.5 1 0 0 1 1 1 0 Bacterial TniB protein PhoH PF02562.16 EDO19261.1 - 0.11 12.0 5.1 0.24 10.8 3.3 2.4 2 1 0 2 2 2 0 PhoH-like protein PRK PF00485.18 EDO19262.1 - 6.7e-10 39.0 0.2 8.7e-09 35.4 0.0 2.0 1 1 1 2 2 2 1 Phosphoribulokinase / Uridine kinase family DUF3073 PF11273.8 EDO19262.1 - 0.14 12.9 0.1 0.27 12.0 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3073) CbiG_N PF11760.8 EDO19262.1 - 0.15 12.1 0.0 0.28 11.2 0.0 1.4 1 0 0 1 1 1 0 Cobalamin synthesis G N-terminal GCV_T PF01571.21 EDO19263.1 - 4.5e-86 288.4 0.0 5.5e-86 288.1 0.0 1.1 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain GCV_T_C PF08669.11 EDO19263.1 - 5.6e-11 42.2 0.0 1.4e-10 40.9 0.0 1.7 1 0 0 1 1 1 1 Glycine cleavage T-protein C-terminal barrel domain Av_adeno_fibre PF06536.11 EDO19263.1 - 0.032 14.1 0.1 0.075 12.9 0.1 1.6 1 0 0 1 1 1 0 Avian adenovirus fibre, N-terminal Acyltransferase PF01553.21 EDO19264.1 - 5.5e-27 94.0 0.0 9.2e-27 93.3 0.0 1.4 1 0 0 1 1 1 1 Acyltransferase Acyltransf_C PF16076.5 EDO19264.1 - 2.3e-13 50.0 1.4 3.5e-13 49.4 0.1 2.0 2 0 0 2 2 2 1 Acyltransferase C-terminus AMP-binding PF00501.28 EDO19265.1 - 2.1e-53 181.5 0.0 2.8e-53 181.0 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EDO19265.1 - 0.018 16.0 0.0 0.036 15.0 0.0 1.5 1 0 0 1 1 1 0 AMP-binding enzyme C-terminal domain ATP-synt PF00231.19 EDO19266.1 - 1.4e-71 241.5 8.5 1.6e-71 241.3 8.5 1.0 1 0 0 1 1 1 1 ATP synthase GAPT PF11770.8 EDO19267.1 - 0.0071 16.2 0.5 0.012 15.5 0.5 1.2 1 0 0 1 1 1 1 GRB2-binding adapter (GAPT) CRCB PF02537.15 EDO19268.1 - 4.5e-27 94.2 17.7 4.9e-17 62.0 3.9 2.5 3 0 0 3 3 3 2 CrcB-like protein, Camphor Resistance (CrcB) Bac_rhodopsin PF01036.18 EDO19268.1 - 0.0025 17.4 0.9 0.0049 16.5 0.4 1.7 1 1 0 1 1 1 1 Bacteriorhodopsin-like protein Rcd1 PF04078.13 EDO19268.1 - 0.078 12.3 0.0 0.13 11.5 0.0 1.3 1 0 0 1 1 1 0 Cell differentiation family, Rcd1-like GWT1 PF06423.12 EDO19268.1 - 0.71 10.0 6.9 4.6 7.4 6.0 2.7 1 1 0 1 1 1 0 GWT1 NatB_MDM20 PF09797.9 EDO19270.1 - 1.1e-40 139.8 9.2 1.2e-39 136.4 9.2 2.2 1 1 0 1 1 1 1 N-acetyltransferase B complex (NatB) non catalytic subunit Hormone_2 PF00123.20 EDO19270.1 - 4.7 7.2 5.9 21 5.1 0.0 3.8 4 0 0 4 4 4 0 Peptide hormone ATP19 PF11022.8 EDO19271.1 - 7.6e-24 83.9 0.1 8.5e-24 83.7 0.1 1.0 1 0 0 1 1 1 1 ATP synthase subunit K Peptidase_S10 PF00450.22 EDO19272.1 - 3.1e-122 409.0 0.1 3.9e-122 408.7 0.1 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase MSG PF02349.15 EDO19272.1 - 1.1 9.5 3.9 2 8.7 3.9 1.5 1 1 0 1 1 1 0 Major surface glycoprotein RasGAP PF00616.19 EDO19273.1 - 5.7e-16 58.9 4.8 3.7e-15 56.2 1.7 4.3 3 1 1 4 4 4 2 GTPase-activator protein for Ras-like GTPase Bmt2 PF11968.8 EDO19274.1 - 7.6e-85 284.2 0.2 1e-84 283.8 0.2 1.2 1 0 0 1 1 1 1 25S rRNA (adenine(2142)-N(1))-methyltransferase, Bmt2 Med18 PF09637.10 EDO19274.1 - 0.037 13.9 0.0 0.05 13.4 0.0 1.3 1 1 0 1 1 1 0 Med18 protein DEAD PF00270.29 EDO19275.1 - 6.8e-42 143.2 0.0 1.7e-41 141.9 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDO19275.1 - 3.9e-29 101.2 0.6 5e-27 94.4 0.1 3.3 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDO19275.1 - 1e-07 32.2 0.9 4.3e-07 30.1 0.0 2.5 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit TniB PF05621.11 EDO19275.1 - 0.036 13.5 0.2 8.5 5.7 0.0 2.7 2 0 0 2 2 2 0 Bacterial TniB protein eRF1_2 PF03464.15 EDO19276.1 - 2.7e-45 153.9 0.2 5.1e-45 153.0 0.2 1.5 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.15 EDO19276.1 - 3.4e-37 127.4 0.4 7.1e-37 126.3 0.4 1.6 1 0 0 1 1 1 1 eRF1 domain 3 eRF1_1 PF03463.15 EDO19276.1 - 7.2e-21 74.5 0.0 1.3e-20 73.7 0.0 1.5 1 0 0 1 1 1 1 eRF1 domain 1 acVLRF1 PF18859.1 EDO19276.1 - 2.6e-10 40.7 0.1 4.1e-10 40.1 0.1 1.3 1 0 0 1 1 1 1 Actinobacteria/chloroflexi VLRF1 release factor baeRF_family10 PF18854.1 EDO19276.1 - 1.1e-08 35.5 0.1 2.1e-08 34.5 0.1 1.5 2 0 0 2 2 2 1 Bacterial archaeo-eukaryotic release factor family 10 Tnp_DNA_bind PF14706.6 EDO19276.1 - 0.12 12.3 0.0 0.22 11.4 0.0 1.5 1 0 0 1 1 1 0 Transposase DNA-binding PTSIIB_sorb PF03830.15 EDO19276.1 - 0.3 11.3 1.9 0.83 9.9 0.1 2.4 3 0 0 3 3 3 0 PTS system sorbose subfamily IIB component ADH_N PF08240.12 EDO19277.1 - 2.8e-27 94.7 0.3 8.5e-27 93.2 0.3 1.8 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EDO19277.1 - 5e-23 81.5 1.4 8.6e-23 80.7 1.4 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EDO19277.1 - 3.8e-05 24.8 0.0 7.3e-05 23.8 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Ribosomal_S9 PF00380.19 EDO19278.1 - 5.5e-41 139.9 0.0 9e-41 139.2 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S9/S16 NfrA_C PF13283.6 EDO19278.1 - 0.12 11.9 0.0 1 8.8 0.0 2.1 2 0 0 2 2 2 0 Bacteriophage N adsorption protein A C-term CENP-S PF15630.6 EDO19279.1 - 2.7e-25 88.5 0.0 3.4e-25 88.2 0.0 1.1 1 0 0 1 1 1 1 CENP-S protein CENP-T_C PF15511.6 EDO19279.1 - 2.5e-07 30.8 0.1 4.2e-07 30.1 0.1 1.4 1 1 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold Histone PF00125.24 EDO19279.1 - 0.037 14.4 0.0 0.04 14.3 0.0 1.2 1 0 0 1 1 1 0 Core histone H2A/H2B/H3/H4 DUF3337 PF11816.8 EDO19280.1 - 5.1e-29 101.3 5.9 7.2e-29 100.9 3.5 2.3 2 1 0 2 2 2 1 Domain of unknown function (DUF3337) WD40 PF00400.32 EDO19280.1 - 4.2e-07 30.6 13.2 0.019 15.8 0.1 5.6 5 0 0 5 5 5 2 WD domain, G-beta repeat RAWUL PF16207.5 EDO19280.1 - 0.00018 22.1 0.2 0.011 16.4 0.1 2.9 2 0 0 2 2 2 1 RAWUL domain RING finger- and WD40-associated ubiquitin-like Ge1_WD40 PF16529.5 EDO19280.1 - 0.0048 15.9 0.1 1.3 7.9 0.0 2.4 1 1 1 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein RNR_inhib PF08591.10 EDO19280.1 - 0.45 11.8 3.3 0.56 11.5 0.7 2.5 2 0 0 2 2 2 0 Ribonucleotide reductase inhibitor RNA_pol_Rpb5_C PF01191.19 EDO19281.1 - 5.5e-32 109.5 1.3 8.9e-32 108.8 0.4 1.8 2 0 0 2 2 2 1 RNA polymerase Rpb5, C-terminal domain RNA_pol_Rpb5_N PF03871.14 EDO19281.1 - 5.9e-30 103.7 0.6 1.1e-29 102.9 0.6 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb5, N-terminal domain Sof1 PF04158.14 EDO19281.1 - 0.021 15.1 0.5 0.042 14.1 0.5 1.4 1 0 0 1 1 1 0 Sof1-like domain Mrr_cat PF04471.12 EDO19281.1 - 0.059 13.4 0.0 0.12 12.4 0.0 1.4 1 0 0 1 1 1 0 Restriction endonuclease SH3_2 PF07653.17 EDO19281.1 - 0.084 12.6 0.0 0.31 10.8 0.0 2.0 2 0 0 2 2 2 0 Variant SH3 domain MFAP1 PF06991.11 EDO19282.1 - 0.0029 17.5 13.9 0.0029 17.5 13.9 2.1 2 0 0 2 2 2 1 Microfibril-associated/Pre-mRNA processing Thioredoxin PF00085.20 EDO19283.1 - 8.7e-15 54.6 0.1 3.3e-14 52.7 0.0 1.9 2 0 0 2 2 2 1 Thioredoxin Thioredoxin_8 PF13905.6 EDO19283.1 - 0.017 15.5 1.4 0.035 14.4 0.1 2.3 2 1 0 2 2 2 0 Thioredoxin-like Thioredoxin_2 PF13098.6 EDO19283.1 - 0.11 13.0 0.0 0.32 11.5 0.0 1.8 1 0 0 1 1 1 0 Thioredoxin-like domain OST3_OST6 PF04756.13 EDO19283.1 - 0.19 11.0 0.8 0.75 9.1 0.0 1.9 1 1 1 2 2 2 0 OST3 / OST6 family, transporter family Aldose_epim PF01263.20 EDO19284.1 - 1.7e-75 254.1 0.4 2.3e-75 253.7 0.4 1.1 1 0 0 1 1 1 1 Aldose 1-epimerase GDP_Man_Dehyd PF16363.5 EDO19284.1 - 2.4e-56 191.5 0.0 3.4e-56 191.0 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 EDO19284.1 - 7.8e-55 185.9 0.0 1.2e-54 185.3 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 EDO19284.1 - 2.1e-18 66.5 0.0 1.5e-16 60.4 0.0 2.2 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.19 EDO19284.1 - 8.1e-16 57.8 0.0 4.3e-15 55.5 0.0 1.9 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 EDO19284.1 - 3.6e-10 39.4 0.0 6.2e-10 38.6 0.0 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain KR PF08659.10 EDO19284.1 - 6.1e-09 36.0 0.0 1.1e-08 35.2 0.0 1.3 1 0 0 1 1 1 1 KR domain adh_short PF00106.25 EDO19284.1 - 6.5e-08 32.3 0.0 1.1e-07 31.6 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase NAD_binding_4 PF07993.12 EDO19284.1 - 2e-06 27.2 0.0 0.00084 18.6 0.0 2.3 2 0 0 2 2 2 2 Male sterility protein NAD_binding_10 PF13460.6 EDO19284.1 - 5.3e-05 23.2 0.0 0.00011 22.2 0.0 1.5 1 0 0 1 1 1 1 NAD(P)H-binding Sacchrp_dh_NADP PF03435.18 EDO19284.1 - 0.027 14.7 0.0 0.094 13.0 0.0 1.9 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain NmrA PF05368.13 EDO19284.1 - 0.028 14.0 0.1 0.078 12.5 0.0 1.8 2 0 0 2 2 2 0 NmrA-like family GalKase_gal_bdg PF10509.9 EDO19285.1 - 1.8e-20 72.2 0.0 3.3e-20 71.4 0.0 1.5 1 0 0 1 1 1 1 Galactokinase galactose-binding signature GHMP_kinases_C PF08544.13 EDO19285.1 - 4.1e-10 39.9 0.1 9.3e-10 38.7 0.1 1.6 1 0 0 1 1 1 1 GHMP kinases C terminal GHMP_kinases_N PF00288.26 EDO19285.1 - 3.5e-09 36.8 0.4 8.7e-09 35.5 0.4 1.7 1 0 0 1 1 1 1 GHMP kinases N terminal domain Sigma70_r4 PF04545.16 EDO19285.1 - 0.035 13.6 0.1 0.083 12.4 0.0 1.7 2 0 0 2 2 2 0 Sigma-70, region 4 HTH_17 PF12728.7 EDO19285.1 - 0.054 13.7 0.0 0.16 12.2 0.0 1.8 1 0 0 1 1 1 0 Helix-turn-helix domain ABC2_membrane PF01061.24 EDO19286.1 - 3.4e-65 219.4 50.8 1.4e-39 135.7 13.6 2.3 2 0 0 2 2 2 2 ABC-2 type transporter ABC_tran PF00005.27 EDO19286.1 - 7.6e-36 123.7 0.0 3.4e-17 63.2 0.0 3.0 3 0 0 3 3 3 2 ABC transporter PDR_CDR PF06422.12 EDO19286.1 - 1.8e-34 117.5 6.5 1.3e-30 105.2 0.1 3.5 2 0 0 2 2 2 2 CDR ABC transporter ABC2_membrane_3 PF12698.7 EDO19286.1 - 7.3e-10 38.5 11.4 7.3e-10 38.5 11.4 3.0 2 1 0 2 2 2 1 ABC-2 family transporter protein ABC_trans_N PF14510.6 EDO19286.1 - 5.6e-09 36.5 0.0 2.6e-08 34.4 0.0 2.2 2 0 0 2 2 1 1 ABC-transporter N-terminal RsgA_GTPase PF03193.16 EDO19286.1 - 5.2e-06 26.5 0.0 0.00086 19.3 0.0 2.5 2 0 0 2 2 2 1 RsgA GTPase AAA_21 PF13304.6 EDO19286.1 - 3.4e-05 23.8 0.0 0.033 14.0 0.0 2.4 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 EDO19286.1 - 0.00011 22.6 0.2 0.0046 17.3 0.0 2.7 2 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 EDO19286.1 - 0.0029 17.9 0.0 0.02 15.2 0.0 2.4 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 EDO19286.1 - 0.0042 17.2 0.2 0.11 12.6 0.0 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase SMC_N PF02463.19 EDO19286.1 - 0.0057 16.1 0.0 0.73 9.2 0.0 3.1 3 0 0 3 3 3 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EDO19286.1 - 0.014 15.1 0.1 0.22 11.3 0.1 2.4 2 0 0 2 2 2 0 P-loop containing region of AAA domain cobW PF02492.19 EDO19286.1 - 0.016 14.8 0.1 0.044 13.4 0.1 1.7 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_25 PF13481.6 EDO19286.1 - 0.028 14.0 0.0 0.1 12.2 0.0 1.9 2 0 0 2 2 1 0 AAA domain AAA_18 PF13238.6 EDO19286.1 - 0.036 14.6 0.0 0.16 12.5 0.0 2.2 2 0 0 2 2 1 0 AAA domain AAA_23 PF13476.6 EDO19286.1 - 0.055 14.0 0.4 0.38 11.2 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 EDO19286.1 - 0.071 13.4 0.1 0.26 11.5 0.0 2.1 2 0 0 2 2 1 0 AAA domain AAA_30 PF13604.6 EDO19286.1 - 0.088 12.5 0.2 1.5 8.5 0.0 2.5 3 0 0 3 3 3 0 AAA domain Dynamin_N PF00350.23 EDO19286.1 - 0.091 12.8 1.0 0.4 10.7 0.0 2.3 2 0 0 2 2 2 0 Dynamin family ABC_ATPase PF09818.9 EDO19286.1 - 0.11 11.3 0.1 0.2 10.4 0.1 1.3 1 0 0 1 1 1 0 Predicted ATPase of the ABC class AAA_24 PF13479.6 EDO19286.1 - 0.11 12.2 0.0 0.45 10.2 0.0 2.0 1 0 0 1 1 1 0 AAA domain TMEM18 PF14770.6 EDO19286.1 - 0.12 12.3 3.5 1.8 8.6 0.6 2.7 2 0 0 2 2 2 0 Transmembrane protein 18 NACHT PF05729.12 EDO19286.1 - 0.22 11.4 0.5 0.5 10.3 0.1 1.8 2 0 0 2 2 2 0 NACHT domain DUF3340 PF11818.8 EDO19286.1 - 0.23 11.6 2.9 0.77 9.9 2.4 2.0 2 0 0 2 2 2 0 C-terminal domain of tail specific protease (DUF3340) DUF5314 PF17241.2 EDO19288.1 - 1.6e-57 194.4 0.1 1.9e-57 194.1 0.1 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5314) Transp_cyt_pur PF02133.15 EDO19289.1 - 7.2e-174 578.7 35.2 8.4e-174 578.5 35.2 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Chitin_synth_2 PF03142.15 EDO19290.1 - 2.9e-269 894.1 0.2 4.5e-269 893.4 0.2 1.1 1 0 0 1 1 1 1 Chitin synthase Glyco_tranf_2_3 PF13641.6 EDO19290.1 - 1.5e-11 44.6 0.0 4.6e-09 36.5 0.0 2.5 2 0 0 2 2 2 2 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.6 EDO19290.1 - 5.1e-11 42.9 7.3 3.1e-10 40.3 7.3 2.4 1 1 0 1 1 1 1 Glycosyl transferase family group 2 Glycos_transf_2 PF00535.26 EDO19290.1 - 0.00058 19.7 0.0 0.25 11.2 0.0 3.4 1 1 2 3 3 3 1 Glycosyl transferase family 2 Glyco_transf_21 PF13506.6 EDO19290.1 - 0.00096 18.7 0.1 0.0026 17.3 0.0 1.6 2 0 0 2 2 2 1 Glycosyl transferase family 21 CemA PF03040.14 EDO19290.1 - 0.086 12.8 0.4 0.17 11.8 0.4 1.5 1 0 0 1 1 1 0 CemA family DUF2681 PF10883.8 EDO19290.1 - 0.17 12.3 1.9 0.2 12.1 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) Chitin_synth_1 PF01644.17 EDO19291.1 - 9.4e-70 233.8 0.4 1.5e-69 233.1 0.4 1.4 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_2 PF03142.15 EDO19291.1 - 1.5e-23 83.2 4.8 1e-17 64.0 0.0 3.1 2 1 0 3 3 3 2 Chitin synthase Chitin_synth_1N PF08407.11 EDO19291.1 - 8.9e-20 70.4 0.1 2.8e-19 68.8 0.1 1.9 1 0 0 1 1 1 1 Chitin synthase N-terminal Glyco_trans_2_3 PF13632.6 EDO19291.1 - 4.7e-10 39.7 0.2 4.7e-10 39.7 0.2 2.7 4 0 0 4 4 4 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 EDO19291.1 - 0.00016 21.7 0.0 0.00072 19.5 0.0 1.9 2 0 0 2 2 2 1 Glycosyltransferase like family 2 YchF-GTPase_C PF06071.13 EDO19292.1 - 1.7e-37 127.5 0.4 7.6e-37 125.4 0.1 2.3 2 1 1 3 3 3 1 Protein of unknown function (DUF933) MMR_HSR1 PF01926.23 EDO19292.1 - 9.1e-17 61.2 0.0 2.1e-16 60.0 0.0 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase TGS PF02824.21 EDO19292.1 - 0.00041 20.3 0.0 0.0011 19.0 0.0 1.7 1 0 0 1 1 1 1 TGS domain FeoB_N PF02421.18 EDO19292.1 - 0.0091 15.5 0.0 0.019 14.5 0.0 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B Cupin_2 PF07883.11 EDO19292.1 - 0.084 12.6 0.0 0.18 11.5 0.0 1.5 1 0 0 1 1 1 0 Cupin domain PhaC_N PF07167.13 EDO19292.1 - 0.15 11.7 0.0 0.33 10.6 0.0 1.6 1 0 0 1 1 1 0 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus AAA_23 PF13476.6 EDO19292.1 - 3.4 8.1 5.8 31 5.0 5.9 2.2 1 1 0 1 1 1 0 AAA domain ADH_zinc_N PF00107.26 EDO19293.1 - 3.9e-08 33.3 0.0 6.4e-08 32.6 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase DUF4974 PF16344.5 EDO19293.1 - 0.13 12.3 0.1 0.34 11.0 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4974) DRIM PF07539.12 EDO19294.1 - 5.2e-160 533.8 5.1 5.2e-160 533.8 5.1 4.4 5 0 0 5 5 5 1 Down-regulated in metastasis UNC45-central PF11701.8 EDO19294.1 - 0.00056 19.9 1.8 0.012 15.6 0.1 4.1 4 0 0 4 4 4 1 Myosin-binding striated muscle assembly central V-ATPase_H_C PF11698.8 EDO19294.1 - 0.028 14.5 4.3 0.31 11.2 0.1 5.0 4 0 0 4 4 4 0 V-ATPase subunit H HEAT_2 PF13646.6 EDO19294.1 - 0.11 12.9 0.0 8.2 6.9 0.0 3.8 3 0 0 3 3 3 0 HEAT repeats Erf4 PF10256.9 EDO19294.1 - 1.5 9.0 4.8 3.2 7.9 0.0 4.2 5 0 0 5 5 5 0 Golgin subfamily A member 7/ERF4 family Thiamine_BP PF01910.17 EDO19295.1 - 5.7e-29 99.9 0.1 6.4e-29 99.7 0.1 1.0 1 0 0 1 1 1 1 Thiamine-binding protein WD40_3 PF15911.5 EDO19295.1 - 0.06 13.3 0.0 0.11 12.5 0.0 1.4 1 0 0 1 1 1 0 WD domain, G-beta repeat Trehalase PF01204.18 EDO19296.1 - 1.8e-189 630.9 0.1 2.1e-189 630.6 0.1 1.0 1 0 0 1 1 1 1 Trehalase Trehalase_Ca-bi PF07492.11 EDO19296.1 - 1.2e-16 60.1 0.9 2.1e-16 59.3 0.9 1.4 1 0 0 1 1 1 1 Neutral trehalase Ca2+ binding domain W_rich_C PF07483.11 EDO19296.1 - 0.028 14.6 0.0 1.4 9.1 0.0 2.5 2 0 0 2 2 2 0 Tryptophan-rich Synechocystis species C-terminal domain Prenyltransf PF01255.19 EDO19297.1 - 1.2e-73 247.4 0.0 1.4e-73 247.1 0.0 1.1 1 0 0 1 1 1 1 Putative undecaprenyl diphosphate synthase polyprenyl_synt PF00348.17 EDO19298.1 - 3.3e-69 232.8 0.0 1.1e-67 227.8 0.0 2.7 1 1 0 1 1 1 1 Polyprenyl synthetase HEPPP_synt_1 PF07307.11 EDO19298.1 - 0.16 11.6 0.0 0.29 10.7 0.0 1.3 1 0 0 1 1 1 0 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1 RCR PF12273.8 EDO19299.1 - 4.8e-27 95.0 0.1 6.5e-27 94.5 0.1 1.1 1 0 0 1 1 1 1 Chitin synthesis regulation, resistance to Congo red TMEM132D_C PF15706.5 EDO19299.1 - 0.052 13.3 0.0 0.095 12.5 0.0 1.5 1 0 0 1 1 1 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term SLC3A2_N PF16028.5 EDO19299.1 - 0.08 12.5 1.0 0.13 11.8 1.0 1.3 1 0 0 1 1 1 0 Solute carrier family 3 member 2 N-terminus Rad51 PF08423.11 EDO19300.1 - 1.6e-44 152.1 0.0 5e-37 127.6 0.0 2.5 2 1 0 2 2 2 2 Rad51 RecA PF00154.21 EDO19300.1 - 1.3e-07 31.4 0.5 7.4e-07 28.9 0.5 2.0 1 1 0 1 1 1 1 recA bacterial DNA recombination protein AAA_25 PF13481.6 EDO19300.1 - 3.1e-05 23.6 0.0 8.8e-05 22.2 0.0 1.7 2 0 0 2 2 2 1 AAA domain ATPase PF06745.13 EDO19300.1 - 0.00013 21.4 3.5 0.0012 18.3 3.5 2.3 1 1 0 1 1 1 1 KaiC NUP214 PF16755.5 EDO19300.1 - 0.00077 18.8 1.0 0.0013 18.1 1.0 1.3 1 0 0 1 1 1 1 Nucleoporin or Nuclear pore complex subunit NUP214=Nup159 AAA_24 PF13479.6 EDO19300.1 - 0.033 13.9 0.2 0.18 11.5 0.0 2.1 2 0 0 2 2 2 0 AAA domain Herpes_TAF50 PF03326.13 EDO19300.1 - 0.11 11.1 0.0 0.15 10.7 0.0 1.1 1 0 0 1 1 1 0 Herpesvirus transcription activation factor (transactivator) Sel1 PF08238.12 EDO19301.1 - 2.3e-08 34.4 3.9 5.6e-05 23.7 0.1 3.5 3 0 0 3 3 3 3 Sel1 repeat KLRAQ PF10205.9 EDO19301.1 - 0.0031 17.7 2.9 0.0031 17.7 2.9 2.5 3 0 0 3 3 3 1 Predicted coiled-coil domain-containing protein EF-G-binding_N PF07299.11 EDO19301.1 - 3.8 8.1 6.6 8.1 7.0 5.0 2.3 2 0 0 2 2 2 0 Elongation factor G-binding protein, N-terminal CENP-T_C PF15511.6 EDO19302.1 - 1.9e-09 37.6 0.1 2.2e-09 37.4 0.1 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold Histone PF00125.24 EDO19302.1 - 2.1e-05 24.9 0.1 2.5e-05 24.7 0.1 1.2 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TAF PF02969.17 EDO19302.1 - 3e-05 24.1 0.1 4.2e-05 23.6 0.1 1.3 1 0 0 1 1 1 1 TATA box binding protein associated factor (TAF) CBFD_NFYB_HMF PF00808.23 EDO19302.1 - 3.6e-05 24.0 0.1 6.1e-05 23.2 0.0 1.5 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-S PF15630.6 EDO19302.1 - 0.00017 21.9 0.1 0.00023 21.5 0.1 1.4 1 1 0 1 1 1 1 CENP-S protein TFIID-31kDa PF02291.15 EDO19302.1 - 0.0029 17.7 0.0 0.0035 17.4 0.0 1.1 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 EDO19302.1 - 0.0067 16.4 0.0 0.0096 15.9 0.0 1.2 1 0 0 1 1 1 1 Bromodomain associated TFIID_20kDa PF03847.13 EDO19302.1 - 0.043 14.3 0.0 0.072 13.6 0.0 1.4 1 0 0 1 1 1 0 Transcription initiation factor TFIID subunit A Histone PF00125.24 EDO19303.1 - 3.1e-49 166.7 3.4 3.4e-49 166.5 3.4 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.6 EDO19303.1 - 2e-06 28.1 0.0 3e-06 27.5 0.0 1.2 1 0 0 1 1 1 1 CENP-S protein PAF PF15715.5 EDO19303.1 - 5.5e-05 23.8 1.3 6.9e-05 23.5 1.3 1.2 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CENP-T_C PF15511.6 EDO19303.1 - 0.00011 22.3 0.8 0.00015 21.9 0.1 1.6 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold CBFD_NFYB_HMF PF00808.23 EDO19303.1 - 0.0018 18.5 0.9 0.0023 18.2 0.1 1.6 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 EDO19303.1 - 0.035 14.2 0.2 0.058 13.5 0.0 1.5 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit Pyrophosphatase PF00719.19 EDO19304.1 - 1.3e-58 197.4 0.5 1.7e-58 196.9 0.5 1.2 1 0 0 1 1 1 1 Inorganic pyrophosphatase Mannosyl_trans3 PF11051.8 EDO19305.1 - 2.9e-83 279.4 0.9 4.9e-83 278.7 0.0 1.9 2 0 0 2 2 2 1 Mannosyltransferase putative Presenilin PF01080.17 EDO19305.1 - 0.58 8.9 7.9 0.9 8.2 7.9 1.3 1 0 0 1 1 1 0 Presenilin Zip PF02535.22 EDO19305.1 - 0.61 9.3 2.7 0.81 8.8 2.7 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Macoilin PF09726.9 EDO19305.1 - 0.62 8.5 10.7 0.81 8.2 10.7 1.1 1 0 0 1 1 1 0 Macoilin family Tim54 PF11711.8 EDO19305.1 - 2.3 6.9 8.5 4.1 6.1 8.5 1.3 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF2076 PF09849.9 EDO19305.1 - 3.6 7.6 15.1 5.8 6.9 15.1 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) ASD2 PF08687.11 EDO19305.1 - 6 6.3 9.1 9.7 5.6 9.1 1.2 1 0 0 1 1 1 0 Apx/Shroom domain ASD2 CYSTM PF12734.7 EDO19306.1 - 0.22 11.9 74.4 1.8e+04 -23.0 74.4 4.8 1 1 0 1 1 1 0 Cysteine-rich TM module stress tolerance Pex14_N PF04695.13 EDO19306.1 - 0.22 12.1 15.7 0.25 12.0 15.7 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region zf-C3HC4 PF00097.25 EDO19307.1 - 0.00073 19.4 1.3 0.0019 18.0 1.3 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EDO19307.1 - 0.0023 17.7 0.1 0.0067 16.2 0.1 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EDO19307.1 - 0.0041 17.2 0.1 0.013 15.6 0.1 1.8 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.6 EDO19307.1 - 0.009 16.0 1.2 0.03 14.3 1.2 1.9 1 1 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 EDO19307.1 - 0.0099 15.8 6.1 0.028 14.4 6.1 1.8 1 1 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 EDO19307.1 - 0.22 11.4 2.0 0.22 11.4 0.3 1.9 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 IBR PF01485.21 EDO19307.1 - 1.3 9.3 5.3 2.2 8.6 1.8 2.5 2 0 0 2 2 2 0 IBR domain, a half RING-finger domain Use1 PF09753.9 EDO19308.1 - 6.8e-10 39.1 0.8 1.3e-09 38.1 0.8 1.5 1 1 0 1 1 1 1 Membrane fusion protein Use1 SRP54_N PF02881.19 EDO19308.1 - 0.0053 16.9 2.6 0.68 10.2 0.0 2.9 3 0 0 3 3 3 2 SRP54-type protein, helical bundle domain Bacillus_HBL PF05791.11 EDO19308.1 - 0.056 13.3 0.7 0.056 13.3 0.7 2.1 2 0 0 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) F-protein PF00469.20 EDO19308.1 - 0.52 9.9 4.9 0.6 9.7 0.4 2.1 1 1 1 2 2 2 0 Negative factor, (F-Protein) or Nef SVM_signal PF12113.8 EDO19308.1 - 1.4 8.9 4.5 1.3 9.0 1.6 2.4 2 0 0 2 2 2 0 SVM protein signal sequence Bystin PF05291.11 EDO19309.1 - 1.5e-123 411.8 0.0 2.1e-123 411.3 0.0 1.1 1 0 0 1 1 1 1 Bystin Arrestin_N PF00339.29 EDO19310.1 - 0.0005 20.2 3.3 0.00069 19.7 0.3 2.4 2 0 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain Homeobox_KN PF05920.11 EDO19311.1 - 9.5e-20 70.2 2.6 1.4e-19 69.7 1.4 2.0 2 0 0 2 2 2 1 Homeobox KN domain Homeodomain PF00046.29 EDO19311.1 - 1.4e-06 28.0 3.4 1.6e-06 27.9 0.7 2.2 2 0 0 2 2 2 1 Homeodomain Viral_env_E26 PF11050.8 EDO19311.1 - 0.012 15.0 0.8 0.027 13.9 0.8 1.5 1 0 0 1 1 1 0 Virus envelope protein E26 Avl9 PF09794.9 EDO19312.1 - 4.3e-152 506.2 1.7 4.3e-152 506.2 1.7 1.7 2 0 0 2 2 2 1 Transport protein Avl9 SPA PF08616.10 EDO19312.1 - 3e-06 27.2 4.3 0.071 13.1 0.2 3.2 2 1 0 3 3 3 2 Stabilization of polarity axis DENN PF02141.21 EDO19312.1 - 0.0077 16.2 0.6 0.46 10.4 0.6 2.5 1 1 0 1 1 1 1 DENN (AEX-3) domain efThoc1 PF11957.8 EDO19313.1 - 2e-112 376.4 26.5 2e-112 376.4 26.5 2.0 2 0 0 2 2 2 1 THO complex subunit 1 transcription elongation factor Lactamase_B_6 PF16661.5 EDO19314.1 - 8.6e-78 260.2 0.1 1.8e-77 259.2 0.1 1.6 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain CPSF100_C PF13299.6 EDO19314.1 - 1.1e-20 74.5 8.5 6.8e-20 71.9 0.8 4.0 4 1 0 4 4 4 1 Cleavage and polyadenylation factor 2 C-terminal DUF4588 PF15251.6 EDO19314.1 - 0.023 14.5 0.2 0.045 13.5 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4588) SF1-HH PF16275.5 EDO19315.1 - 6.1e-42 142.5 1.2 6.1e-42 142.5 1.2 3.1 3 0 0 3 3 3 1 Splicing factor 1 helix-hairpin domain zf-CCHC PF00098.23 EDO19315.1 - 2.1e-07 30.7 11.3 0.0019 18.2 1.3 2.4 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_3 PF13917.6 EDO19315.1 - 2.5e-07 30.6 10.4 0.00042 20.2 1.5 2.7 1 1 1 2 2 2 2 Zinc knuckle KH_1 PF00013.29 EDO19315.1 - 2.9e-06 27.0 0.0 6.2e-06 25.9 0.0 1.5 1 0 0 1 1 1 1 KH domain zf-CCHC_5 PF14787.6 EDO19315.1 - 0.0076 15.9 4.3 0.032 14.0 0.1 2.5 2 0 0 2 2 2 1 GAG-polyprotein viral zinc-finger zf-CCHC_4 PF14392.6 EDO19315.1 - 0.055 13.2 6.8 2.3 8.0 0.3 2.4 2 0 0 2 2 2 0 Zinc knuckle Collagen PF01391.18 EDO19315.1 - 0.27 11.0 3.1 0.76 9.6 3.1 1.8 1 0 0 1 1 1 0 Collagen triple helix repeat (20 copies) Prim_Zn_Ribbon PF08273.12 EDO19315.1 - 0.7 10.2 3.7 1.4 9.2 3.7 1.5 1 0 0 1 1 1 0 Zinc-binding domain of primase-helicase zf-CCHC_6 PF15288.6 EDO19315.1 - 0.75 9.7 5.7 1.2 9.0 0.2 2.5 1 1 1 2 2 2 0 Zinc knuckle TPR_14 PF13428.6 EDO19316.1 - 7.1e-19 66.9 0.0 0.12 13.3 0.0 9.8 7 2 3 10 10 10 4 Tetratricopeptide repeat HAT PF02184.16 EDO19316.1 - 6.8e-15 54.7 25.9 0.017 15.1 0.1 8.9 8 0 0 8 8 8 5 HAT (Half-A-TPR) repeat TPR_19 PF14559.6 EDO19316.1 - 4.2e-11 43.2 0.0 0.0033 17.9 0.0 6.4 8 0 0 8 8 8 2 Tetratricopeptide repeat Suf PF05843.14 EDO19316.1 - 3.4e-06 27.3 17.6 0.031 14.3 0.8 6.9 2 1 3 5 5 5 2 Suppressor of forked protein (Suf) TPR_17 PF13431.6 EDO19316.1 - 2.7e-05 24.2 0.7 0.019 15.3 0.0 5.1 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_9 PF13371.6 EDO19316.1 - 0.0005 20.2 1.3 0.039 14.1 0.0 3.8 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_15 PF13429.6 EDO19316.1 - 0.00074 18.8 0.1 2 7.5 0.0 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat Mad3_BUB1_I PF08311.12 EDO19316.1 - 0.0015 18.5 11.6 0.027 14.5 2.9 5.2 6 0 0 6 6 6 1 Mad3/BUB1 homology region 1 TPR_2 PF07719.17 EDO19316.1 - 0.0026 17.8 3.4 31 5.0 0.0 6.5 8 0 0 8 8 8 0 Tetratricopeptide repeat U3_assoc_6 PF08640.11 EDO19316.1 - 0.0039 17.2 9.2 0.034 14.2 0.7 4.7 3 2 2 5 5 5 1 U3 small nucleolar RNA-associated protein 6 ubiquitin PF00240.23 EDO19317.1 - 2.1e-24 85.1 1.7 2.3e-24 84.9 1.7 1.0 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 EDO19317.1 - 1e-15 57.3 0.8 1.1e-15 57.2 0.8 1.0 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EDO19317.1 - 0.0004 20.8 0.2 0.0012 19.2 0.2 1.7 1 1 0 1 1 1 1 Ubiquitin-like domain TBK1_ULD PF18396.1 EDO19317.1 - 0.0011 18.9 0.0 0.0012 18.7 0.0 1.1 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_4 PF18036.1 EDO19317.1 - 0.14 12.2 0.4 3.8 7.6 0.1 2.0 1 1 1 2 2 2 0 Ubiquitin-like domain MTS PF05175.14 EDO19318.1 - 7.4e-06 25.6 0.0 1.4e-05 24.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_23 PF13489.6 EDO19318.1 - 0.00054 19.8 0.0 0.02 14.7 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 EDO19318.1 - 0.00089 18.7 0.1 0.0025 17.3 0.0 1.6 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_31 PF13847.6 EDO19318.1 - 0.0015 18.3 0.0 0.0022 17.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EDO19318.1 - 0.0063 17.2 0.0 0.048 14.4 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain OpuAC PF04069.12 EDO19318.1 - 0.14 11.7 0.0 0.26 10.8 0.0 1.4 1 0 0 1 1 1 0 Substrate binding domain of ABC-type glycine betaine transport system Dopey_N PF04118.14 EDO19319.1 - 1.5e-109 365.8 1.5 1.5e-109 365.8 1.5 4.0 4 0 0 4 4 4 1 Dopey, N-terminal WD40 PF00400.32 EDO19320.1 - 1.2e-17 63.9 12.3 0.00061 20.5 0.2 6.4 6 0 0 6 6 6 4 WD domain, G-beta repeat zf-RING_2 PF13639.6 EDO19321.1 - 5.1e-10 39.5 4.9 1.1e-08 35.3 2.7 2.3 2 0 0 2 2 2 1 Ring finger domain zf-rbx1 PF12678.7 EDO19321.1 - 3.2e-07 30.5 3.0 7.4e-07 29.4 1.3 2.2 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 EDO19321.1 - 3e-05 24.0 4.1 8.2e-05 22.6 0.7 2.5 2 0 0 2 2 2 1 RING-type zinc-finger Prok-RING_4 PF14447.6 EDO19321.1 - 3.7e-05 23.5 2.3 3.7e-05 23.5 2.3 1.6 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 EDO19321.1 - 4.6e-05 23.2 2.6 4.6e-05 23.2 2.6 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EDO19321.1 - 0.00038 20.3 3.6 0.00039 20.2 1.7 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EDO19321.1 - 0.00047 20.3 2.0 0.00047 20.3 2.0 1.7 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.6 EDO19321.1 - 0.00066 19.5 1.5 0.00066 19.5 1.5 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EDO19321.1 - 0.0015 18.4 2.6 0.0035 17.3 0.9 2.1 2 0 0 2 2 2 1 zinc-RING finger domain zf-ANAPC11 PF12861.7 EDO19321.1 - 0.011 15.7 1.7 0.033 14.2 0.9 1.9 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger Cullin_binding PF03556.15 EDO19322.1 - 2.4e-25 89.3 3.2 2.4e-25 89.3 3.2 1.8 2 1 0 2 2 2 1 Cullin binding UBA_4 PF14555.6 EDO19322.1 - 5.3e-12 45.4 0.0 1.4e-11 44.0 0.0 1.6 1 0 0 1 1 1 1 UBA-like domain TAP_C PF03943.13 EDO19322.1 - 0.025 14.2 0.1 0.048 13.3 0.1 1.5 1 0 0 1 1 1 0 TAP C-terminal domain TCTP PF00838.17 EDO19322.1 - 0.035 14.5 0.1 0.066 13.6 0.1 1.4 1 0 0 1 1 1 0 Translationally controlled tumour protein WD40 PF00400.32 EDO19323.1 - 5.4e-51 169.4 29.0 3.6e-05 24.5 0.4 11.4 11 0 0 11 11 11 9 WD domain, G-beta repeat Utp12 PF04003.12 EDO19323.1 - 2.3e-19 69.7 0.7 4.4e-19 68.8 0.7 1.5 1 0 0 1 1 1 1 Dip2/Utp12 Family ANAPC4_WD40 PF12894.7 EDO19323.1 - 8.3e-16 58.1 3.8 0.0013 19.0 0.0 7.5 2 2 4 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EDO19323.1 - 1.8e-09 36.8 7.3 0.051 12.2 0.1 6.0 4 3 2 6 6 6 4 Nucleoporin Nup120/160 WD40_like PF17005.5 EDO19323.1 - 5.6e-09 35.8 5.5 0.00026 20.4 0.2 4.6 4 2 1 5 5 5 3 WD40-like domain Ge1_WD40 PF16529.5 EDO19323.1 - 0.00053 19.0 3.1 4.5 6.1 0.0 5.8 4 3 5 9 9 9 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Hira PF07569.11 EDO19323.1 - 0.00055 19.7 1.6 1.1 8.9 0.0 4.6 5 0 0 5 5 5 1 TUP1-like enhancer of split Frtz PF11768.8 EDO19323.1 - 0.00088 17.7 0.0 0.63 8.3 0.0 2.6 2 0 0 2 2 2 2 WD repeat-containing and planar cell polarity effector protein Fritz PALB2_WD40 PF16756.5 EDO19323.1 - 0.0099 14.8 10.2 0.37 9.7 0.1 4.9 4 2 2 6 6 6 1 Partner and localizer of BRCA2 WD40 domain Cas_Csy4 PF09618.10 EDO19323.1 - 0.013 15.6 1.5 0.025 14.8 1.5 1.4 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Csy4) eIF2A PF08662.11 EDO19323.1 - 0.022 14.7 0.2 9.2 6.1 0.0 4.1 3 1 0 3 3 3 0 Eukaryotic translation initiation factor eIF2A ELYS-bb PF16687.5 EDO19323.1 - 0.025 13.2 0.0 0.21 10.1 0.0 2.3 2 0 0 2 2 2 0 beta-propeller of ELYS nucleoporin Pex14_N PF04695.13 EDO19323.1 - 0.097 13.3 0.3 0.2 12.3 0.3 1.5 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Ets PF00178.22 EDO19323.1 - 1.4 9.4 5.5 0.32 11.5 1.1 2.2 2 0 0 2 2 2 0 Ets-domain zf-C2H2 PF00096.26 EDO19324.1 - 2.1e-10 40.5 18.2 0.00035 20.9 2.3 3.9 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EDO19324.1 - 6.2e-06 26.6 11.0 0.11 13.4 0.8 3.7 3 0 0 3 3 3 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EDO19324.1 - 2.2e-05 24.7 13.6 0.0021 18.4 0.1 3.5 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_6 PF13912.6 EDO19324.1 - 0.0021 18.0 4.3 4.2 7.5 0.0 3.4 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EDO19324.1 - 0.0099 16.1 7.1 3.1 8.2 0.3 3.5 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding AT_hook PF02178.19 EDO19324.1 - 0.088 12.7 4.9 0.27 11.2 4.9 1.9 1 0 0 1 1 1 0 AT hook motif zf-TRAF PF02176.18 EDO19324.1 - 0.1 13.3 4.1 0.072 13.8 2.3 1.7 1 1 0 1 1 1 0 TRAF-type zinc finger zf_ZIC PF18366.1 EDO19324.1 - 0.2 11.8 2.6 16 5.7 0.1 3.2 2 1 1 3 3 3 0 Zic proteins zinc finger domain zf-C2H2_8 PF15909.5 EDO19324.1 - 0.27 11.6 2.8 0.81 10.0 2.7 1.8 1 1 0 1 1 1 0 C2H2-type zinc ribbon zf-met PF12874.7 EDO19324.1 - 0.48 10.9 2.1 22 5.6 0.2 3.1 3 0 0 3 3 3 0 Zinc-finger of C2H2 type HVSL PF09749.9 EDO19325.1 - 6.2e-39 133.9 1.6 7.9e-39 133.5 1.6 1.1 1 0 0 1 1 1 1 Uncharacterised conserved protein NAD2 PF18782.1 EDO19325.1 - 0.097 12.8 0.1 0.21 11.7 0.1 1.6 2 0 0 2 2 2 0 Novel AID APOBEC clade 2 Choline_kinase PF01633.20 EDO19326.1 - 5.6e-64 215.6 0.0 8e-64 215.1 0.0 1.2 1 0 0 1 1 1 1 Choline/ethanolamine kinase Choline_kin_N PF04428.14 EDO19326.1 - 9.2e-17 60.5 0.0 2.5e-16 59.1 0.0 1.7 1 0 0 1 1 1 1 Choline kinase N terminus APH PF01636.23 EDO19326.1 - 1.3e-06 28.5 0.0 0.0015 18.5 0.0 2.5 2 1 0 2 2 2 2 Phosphotransferase enzyme family Slx4 PF09494.10 EDO19327.1 - 3.9e-14 52.3 0.1 1.2e-13 50.8 0.1 1.9 1 0 0 1 1 1 1 Slx4 endonuclease IFT81_CH PF18383.1 EDO19327.1 - 0.035 14.4 0.9 0.13 12.5 0.1 2.4 2 0 0 2 2 2 0 Intraflagellar transport 81 calponin homology domain DUF4351 PF14261.6 EDO19327.1 - 0.064 13.3 1.0 22 5.2 0.0 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4351) GAT PF03127.14 EDO19327.1 - 0.35 11.2 3.5 0.37 11.1 1.0 2.4 2 0 0 2 2 2 0 GAT domain DUF668 PF05003.12 EDO19327.1 - 0.66 10.5 3.1 1.4 9.5 0.1 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF668) Peptidase_M28 PF04389.17 EDO19328.1 - 4.5e-20 72.2 0.0 7e-20 71.6 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M28 TFR_dimer PF04253.15 EDO19328.1 - 1.8e-14 53.9 0.0 3.4e-14 53.0 0.0 1.4 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain PA PF02225.22 EDO19328.1 - 4e-10 39.6 0.0 9.8e-10 38.3 0.0 1.6 1 0 0 1 1 1 1 PA domain Peptidase_M20 PF01546.28 EDO19328.1 - 0.019 14.7 0.0 0.036 13.7 0.0 1.4 1 0 0 1 1 1 0 Peptidase family M20/M25/M40 Nicastrin PF05450.15 EDO19328.1 - 0.21 11.1 0.0 0.37 10.2 0.0 1.3 1 0 0 1 1 1 0 Nicastrin COX6C PF02937.15 EDO19328.1 - 0.42 10.8 1.2 25 5.1 0.6 2.6 2 0 0 2 2 2 0 Cytochrome c oxidase subunit VIc RWD PF05773.22 EDO19329.1 - 7.9e-25 87.4 2.3 7.9e-25 87.4 2.3 1.8 2 1 0 2 2 2 1 RWD domain DFRP_C PF16543.5 EDO19329.1 - 9.1e-05 22.9 3.9 9.1e-05 22.9 3.9 3.0 2 1 1 3 3 3 1 DRG Family Regulatory Proteins, Tma46 UEV PF05743.13 EDO19329.1 - 0.0013 18.5 0.0 0.0023 17.8 0.0 1.4 1 0 0 1 1 1 1 UEV domain TssO PF17561.2 EDO19329.1 - 0.95 9.6 5.5 4.8 7.3 5.5 2.1 1 1 0 1 1 1 0 Type VI secretion system, TssO ENTH PF01417.20 EDO19330.1 - 8.8e-35 119.5 0.4 1.8e-34 118.5 0.4 1.5 1 0 0 1 1 1 1 ENTH domain PGA2 PF07543.12 EDO19330.1 - 7.9 6.5 15.2 0.87 9.6 5.4 2.7 3 0 0 3 3 3 0 Protein trafficking PGA2 RNA_polI_A14 PF08203.11 EDO19331.1 - 6.5e-26 90.9 0.2 6.5e-26 90.9 0.2 2.0 2 0 0 2 2 2 1 Yeast RNA polymerase I subunit RPA14 SKA1 PF07160.12 EDO19331.1 - 0.22 11.3 2.0 0.35 10.7 1.9 1.3 1 1 0 1 1 1 0 Spindle and kinetochore-associated protein 1 AATF-Che1 PF13339.6 EDO19331.1 - 0.52 11.0 3.7 0.85 10.3 3.8 1.5 1 1 0 1 1 1 0 Apoptosis antagonizing transcription factor Tape_meas_lam_C PF09718.10 EDO19331.1 - 2.1 8.6 5.1 20 5.4 0.8 2.6 2 1 0 2 2 2 0 Lambda phage tail tape-measure protein (Tape_meas_lam_C) SAC3_GANP PF03399.16 EDO19332.1 - 1.7e-102 342.7 0.1 2.5e-101 338.9 0.0 2.1 2 0 0 2 2 2 1 SAC3/GANP family SAC3 PF12209.8 EDO19332.1 - 6.8e-21 74.2 1.5 1.8e-20 72.8 1.5 1.8 1 0 0 1 1 1 1 Leucine permease transcriptional regulator helical domain rve_3 PF13683.6 EDO19332.1 - 0.16 11.8 2.8 0.78 9.6 0.1 3.5 4 0 0 4 4 4 0 Integrase core domain DUF5640 PF18692.1 EDO19333.1 - 0.026 14.5 0.7 1.1 9.4 0.2 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5640) KID PF02524.14 EDO19333.1 - 0.064 13.3 0.6 0.27 11.5 0.6 2.1 1 0 0 1 1 1 0 KID repeat ING PF12998.7 EDO19333.1 - 0.095 13.3 2.6 0.32 11.6 1.4 2.2 2 0 0 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding Na_H_Exchanger PF00999.21 EDO19334.1 - 4e-86 289.2 26.0 4.9e-86 288.9 26.0 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family Nha1_C PF08619.10 EDO19334.1 - 3.8e-75 253.9 25.6 2.2e-64 218.4 12.6 2.0 1 1 1 2 2 2 2 Alkali metal cation/H+ antiporter Nha1 C terminus TPR_19 PF14559.6 EDO19335.1 - 9.8e-05 22.8 0.6 0.065 13.8 0.0 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 EDO19335.1 - 0.00051 20.0 4.3 1.6 9.1 0.0 5.0 5 0 0 5 5 5 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EDO19335.1 - 0.002 18.3 1.4 1.5 9.1 0.0 3.4 3 0 0 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 EDO19335.1 - 0.011 15.9 0.2 4.1 7.8 0.0 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat SpoVIF PF14069.6 EDO19335.1 - 0.13 12.0 0.6 0.35 10.7 0.1 2.0 2 0 0 2 2 2 0 Stage VI sporulation protein F TPR_1 PF00515.28 EDO19335.1 - 0.17 11.7 5.0 33 4.5 0.0 4.4 5 0 0 5 5 5 0 Tetratricopeptide repeat SLS PF14611.6 EDO19336.1 - 3.5e-44 151.3 1.9 4.1e-44 151.0 0.3 1.9 2 0 0 2 2 2 1 Mitochondrial inner-membrane-bound regulator OEP PF02321.18 EDO19336.1 - 0.009 15.8 0.0 0.02 14.7 0.0 1.5 1 0 0 1 1 1 1 Outer membrane efflux protein FTO_NTD PF12933.7 EDO19337.1 - 0.17 11.1 2.4 0.34 10.1 2.4 1.4 1 0 0 1 1 1 0 FTO catalytic domain Pro_dh PF01619.18 EDO19338.1 - 1.6e-60 205.1 0.0 2.1e-60 204.8 0.0 1.1 1 0 0 1 1 1 1 Proline dehydrogenase Diphthami_syn_2 PF01902.17 EDO19339.1 - 5.8e-33 114.2 0.0 1.9e-32 112.6 0.0 1.9 2 1 0 2 2 2 1 Diphthamide synthase Ribonuc_L-PSP PF01042.21 EDO19339.1 - 1.1e-19 70.6 0.0 1.2e-12 47.9 0.0 2.4 2 0 0 2 2 2 2 Endoribonuclease L-PSP Sec1 PF00995.23 EDO19341.1 - 1.3e-91 308.7 2.3 1.3e-91 308.7 2.3 2.0 2 0 0 2 2 2 1 Sec1 family ABC2_membrane_3 PF12698.7 EDO19341.1 - 0.12 11.5 2.1 0.67 9.0 1.5 2.1 2 0 0 2 2 2 0 ABC-2 family transporter protein Spt20 PF12090.8 EDO19341.1 - 0.24 11.0 24.9 0.56 9.8 24.9 1.6 1 0 0 1 1 1 0 Spt20 family CLN3 PF02487.17 EDO19341.1 - 0.43 9.6 1.1 0.65 9.0 1.1 1.3 1 0 0 1 1 1 0 CLN3 protein Neur_chan_memb PF02932.16 EDO19341.1 - 0.8 9.7 3.5 1.3 9.0 3.5 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region CPSF100_C PF13299.6 EDO19341.1 - 4 7.6 7.0 9.2 6.4 7.0 1.6 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Glyco_hydro81C PF17652.1 EDO19342.1 - 3.7e-79 266.5 8.4 3.7e-79 266.5 8.4 1.5 2 0 0 2 2 2 1 Glycosyl hydrolase family 81 C-terminal domain Glyco_hydro_81 PF03639.13 EDO19342.1 - 4.9e-70 236.2 0.3 9.2e-70 235.3 0.1 1.5 2 0 0 2 2 2 1 Glycosyl hydrolase family 81 N-terminal domain WD40 PF00400.32 EDO19343.1 - 0.00051 20.8 1.6 0.33 11.9 1.7 3.7 3 0 0 3 3 3 1 WD domain, G-beta repeat MMS1_N PF10433.9 EDO19343.1 - 0.0089 14.7 1.6 0.69 8.5 0.0 2.3 2 0 0 2 2 2 2 Mono-functional DNA-alkylating methyl methanesulfonate N-term Lactonase PF10282.9 EDO19343.1 - 0.12 11.6 0.0 0.49 9.6 0.0 1.9 2 0 0 2 2 2 0 Lactonase, 7-bladed beta-propeller LSM PF01423.22 EDO19344.1 - 2.3e-15 56.0 0.3 2.7e-15 55.8 0.3 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EDO19344.1 - 0.039 14.1 0.1 0.064 13.4 0.1 1.4 1 0 0 1 1 1 0 Ataxin 2 SM domain LSM14 PF12701.7 EDO19344.1 - 0.068 13.3 0.0 0.1 12.7 0.0 1.2 1 0 0 1 1 1 0 Scd6-like Sm domain DUF3019 PF11456.8 EDO19344.1 - 0.21 12.1 0.0 0.25 11.9 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3019) Pep3_Vps18 PF05131.14 EDO19345.1 - 1.4e-38 132.1 0.1 3.7e-38 130.7 0.1 1.8 1 0 0 1 1 1 1 Pep3/Vps18/deep orange family Clathrin PF00637.20 EDO19345.1 - 1.7e-09 37.7 3.6 1.7e-09 37.7 3.6 4.1 3 1 0 3 3 3 1 Region in Clathrin and VPS Vps39_2 PF10367.9 EDO19345.1 - 4.2e-05 23.9 0.2 4.2e-05 23.9 0.2 2.8 3 0 0 3 3 3 1 Vacuolar sorting protein 39 domain 2 zf-RING_5 PF14634.6 EDO19345.1 - 0.0011 18.9 8.0 0.0064 16.4 8.0 2.3 1 1 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EDO19345.1 - 0.0011 18.9 0.8 0.0038 17.2 0.8 1.9 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 EDO19345.1 - 0.008 16.0 5.7 0.0099 15.7 1.6 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EDO19345.1 - 0.027 14.2 4.6 0.079 12.7 4.6 1.8 1 0 0 1 1 1 0 RING-like zinc finger zf-C3HC4 PF00097.25 EDO19345.1 - 0.037 13.9 4.7 0.028 14.3 1.3 2.3 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) RNA_pol_Rpb1_7 PF04990.12 EDO19345.1 - 0.13 12.2 4.2 0.73 9.8 1.0 3.1 3 0 0 3 3 3 0 RNA polymerase Rpb1, domain 7 zf-RING_2 PF13639.6 EDO19345.1 - 0.49 10.8 8.8 3.9 7.9 8.8 2.4 1 1 0 1 1 1 0 Ring finger domain zf-rbx1 PF12678.7 EDO19345.1 - 0.74 10.1 4.4 0.5 10.7 0.9 2.3 2 0 0 2 2 2 0 RING-H2 zinc finger domain DUF2415 PF10313.9 EDO19346.1 - 5.3e-22 77.5 0.6 1.3e-21 76.2 0.2 2.0 2 0 0 2 2 2 1 Uncharacterised protein domain (DUF2415) Stb3 PF10330.9 EDO19347.1 - 3.5e-27 94.3 0.0 6.5e-27 93.4 0.0 1.4 1 0 0 1 1 1 1 Putative Sin3 binding protein Stm1_N PF09598.10 EDO19348.1 - 1.9e-08 35.1 3.7 1.9e-08 35.1 3.7 3.7 3 1 1 4 4 4 1 Stm1 HABP4_PAI-RBP1 PF04774.15 EDO19348.1 - 0.0005 20.9 7.0 0.0005 20.9 7.0 2.2 1 1 1 2 2 2 1 Hyaluronan / mRNA binding family FAM176 PF14851.6 EDO19348.1 - 2.1 8.0 5.0 2.7 7.6 4.3 1.5 1 1 0 1 1 1 0 FAM176 family NUDIX PF00293.28 EDO19349.1 - 3.5e-13 49.7 0.0 5.7e-13 49.1 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain Sec7 PF01369.20 EDO19350.1 - 1.2e-70 237.0 0.2 1.2e-70 237.0 0.2 2.5 2 0 0 2 2 2 1 Sec7 domain Sec7_N PF12783.7 EDO19350.1 - 2.6e-44 150.9 0.3 2.6e-44 150.9 0.3 4.3 5 0 0 5 5 5 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DUF1981 PF09324.10 EDO19350.1 - 3.7e-29 100.4 16.7 1e-28 99.0 0.7 6.3 7 0 0 7 7 7 1 Domain of unknown function (DUF1981) DCB PF16213.5 EDO19350.1 - 8.2e-14 51.7 6.1 2.3e-13 50.2 1.4 3.7 3 0 0 3 3 3 1 Dimerisation and cyclophilin-binding domain of Mon2 Nop14 PF04147.12 EDO19350.1 - 3.7e-06 25.5 49.1 3.7e-06 25.5 49.1 3.0 3 0 0 3 3 3 1 Nop14-like family SDA1 PF05285.12 EDO19350.1 - 0.002 17.6 55.0 0.002 17.6 55.0 2.6 3 0 0 3 3 3 1 SDA1 rve_2 PF13333.6 EDO19350.1 - 0.049 13.8 0.0 2.3 8.4 0.0 2.9 2 0 0 2 2 2 0 Integrase core domain DUF3584 PF12128.8 EDO19351.1 - 0.0016 16.0 24.8 0.002 15.7 24.8 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) HtaA PF04213.13 EDO19351.1 - 0.14 12.6 0.4 0.52 10.8 0.2 2.0 1 1 1 2 2 2 0 Htaa MCM_OB PF17207.3 EDO19352.1 - 9 6.2 11.0 19 5.1 11.0 1.5 1 0 0 1 1 1 0 MCM OB domain rve PF00665.26 EDO19353.1 - 5.3e-15 55.7 0.0 7.6e-15 55.2 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain DDE_3 PF13358.6 EDO19353.1 - 0.046 13.5 0.0 0.066 13.0 0.0 1.2 1 0 0 1 1 1 0 DDE superfamily endonuclease NAD_binding_5 PF07994.12 EDO19354.1 - 0.056 12.8 1.8 0.069 12.5 1.8 1.1 1 0 0 1 1 1 0 Myo-inositol-1-phosphate synthase Xpo1 PF08389.12 EDO19354.1 - 0.072 13.2 0.9 0.098 12.7 0.9 1.2 1 0 0 1 1 1 0 Exportin 1-like protein DUF4359 PF14271.6 EDO19354.1 - 0.12 13.2 1.0 0.24 12.2 1.0 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4359) Sp38 PF07354.12 EDO19354.1 - 0.54 9.7 2.9 0.47 9.9 1.9 1.4 2 0 0 2 2 2 0 Zona-pellucida-binding protein (Sp38) GTP_EFTU PF00009.27 EDO19355.1 - 4.9e-45 153.5 0.0 1.3e-44 152.0 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 EDO19355.1 - 7.4e-34 116.4 0.6 2.2e-33 114.9 0.6 1.9 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 EDO19355.1 - 6.6e-08 32.8 0.5 1.8e-07 31.5 0.5 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EDO19355.1 - 0.00088 19.3 0.1 0.0073 16.4 0.1 2.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase AbiJ_NTD3 PF18860.1 EDO19355.1 - 0.05 13.1 0.0 0.11 12.1 0.0 1.4 1 0 0 1 1 1 0 AbiJ N-terminal domain 3 Peptidase_U32_C PF16325.5 EDO19355.1 - 0.12 12.7 0.5 0.37 11.1 0.1 2.0 2 0 0 2 2 2 0 Peptidase family U32 C-terminal domain Ribosomal_L31e PF01198.19 EDO19356.1 - 1.1e-38 131.3 0.7 1.4e-38 131.0 0.7 1.1 1 0 0 1 1 1 1 Ribosomal protein L31e DUF1765 PF08578.10 EDO19357.1 - 3.2e-21 76.1 10.3 3.2e-21 76.1 10.3 3.6 4 1 0 4 4 4 1 Protein of unknown function (DUF1765) Imm26 PF15428.6 EDO19357.1 - 0.071 13.3 1.2 0.32 11.2 0.7 2.4 2 0 0 2 2 2 0 Immunity protein 26 TPK_catalytic PF04263.16 EDO19358.1 - 0.16 12.0 0.1 0.28 11.3 0.1 1.4 1 0 0 1 1 1 0 Thiamin pyrophosphokinase, catalytic domain TFIIA PF03153.13 EDO19359.1 - 4.5e-06 26.9 34.7 6.7e-06 26.3 34.7 1.3 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit zf-C2H2 PF00096.26 EDO19359.1 - 1.9e-05 24.8 17.6 0.015 15.7 1.3 4.3 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EDO19359.1 - 2.9e-05 24.5 14.6 0.037 14.9 0.6 4.4 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_aberr PF17017.5 EDO19359.1 - 0.0067 16.6 0.3 0.0067 16.6 0.3 3.6 4 0 0 4 4 4 2 Aberrant zinc-finger zf-H2C2_2 PF13465.6 EDO19359.1 - 0.018 15.5 18.3 0.097 13.1 1.1 4.2 3 0 0 3 3 3 0 Zinc-finger double domain Suf PF05843.14 EDO19359.1 - 0.96 9.4 15.3 2 8.3 15.3 1.5 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DNA_pol_phi PF04931.13 EDO19359.1 - 1.6 6.7 15.4 3 5.8 15.4 1.4 1 0 0 1 1 1 0 DNA polymerase phi LMBR1 PF04791.16 EDO19359.1 - 8.7 5.1 7.5 15 4.4 7.5 1.4 1 0 0 1 1 1 0 LMBR1-like membrane protein Zn_clus PF00172.18 EDO19360.1 - 2e-09 37.4 14.3 3.3e-09 36.7 14.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain UDPGP PF01704.18 EDO19361.1 - 7.8e-187 621.0 0.0 1.9e-186 619.7 0.0 1.5 2 0 0 2 2 2 1 UTP--glucose-1-phosphate uridylyltransferase zf-rbx1 PF12678.7 EDO19362.1 - 5e-09 36.3 3.4 9.2e-09 35.5 3.4 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 EDO19362.1 - 8.5e-09 35.6 6.4 2.5e-08 34.1 6.4 1.8 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EDO19362.1 - 2.6e-07 30.3 2.3 2.6e-07 30.3 2.3 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EDO19362.1 - 5.6e-07 29.4 2.3 1e-06 28.6 2.3 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 EDO19362.1 - 2.7e-06 27.1 4.3 5.4e-06 26.2 4.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EDO19362.1 - 5.3e-06 26.1 4.0 0.00078 19.1 0.5 2.8 2 0 0 2 2 2 2 RING-like zinc finger zf-RING_UBOX PF13445.6 EDO19362.1 - 3.2e-05 23.9 2.4 8e-05 22.6 2.4 1.8 1 0 0 1 1 1 1 RING-type zinc-finger zf-ANAPC11 PF12861.7 EDO19362.1 - 0.0012 18.8 1.7 0.003 17.6 1.7 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.6 EDO19362.1 - 0.002 18.0 3.8 0.0048 16.7 3.9 1.6 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 EDO19362.1 - 0.0021 17.9 5.8 0.011 15.6 5.8 2.0 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 EDO19362.1 - 0.0044 16.6 1.9 0.0044 16.6 1.9 1.9 2 0 0 2 2 2 1 Zinc-ribbon, C4HC2 type zf-C3H2C3 PF17122.5 EDO19362.1 - 0.071 13.2 1.0 0.2 11.8 1.0 1.8 1 0 0 1 1 1 0 Zinc-finger FANCL_C PF11793.8 EDO19362.1 - 0.073 13.3 5.3 0.32 11.2 5.3 2.1 1 1 0 1 1 1 0 FANCL C-terminal domain zf-RING_6 PF14835.6 EDO19362.1 - 0.28 11.1 0.9 0.6 10.0 0.2 1.8 1 1 1 2 2 2 0 zf-RING of BARD1-type protein DUF2971 PF11185.8 EDO19362.1 - 1.6 10.0 7.0 1.5 10.0 1.1 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF2971) BRAP2 PF07576.12 EDO19363.1 - 6e-30 103.4 1.2 1.6e-29 102.1 0.9 1.9 2 0 0 2 2 1 1 BRCA1-associated protein 2 zf-UBP PF02148.19 EDO19363.1 - 4.6e-22 78.1 7.0 1.3e-21 76.6 7.0 1.8 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein zf-RING_2 PF13639.6 EDO19363.1 - 2.7e-09 37.2 10.1 2.7e-09 37.2 10.1 2.5 2 0 0 2 2 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EDO19363.1 - 4.9e-08 32.7 10.3 4.9e-08 32.7 10.3 2.2 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EDO19363.1 - 4.2e-06 26.4 3.9 4.2e-06 26.4 3.9 2.5 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4 PF00097.25 EDO19363.1 - 1.1e-05 25.2 9.4 1.1e-05 25.2 9.4 2.0 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EDO19363.1 - 1.1e-05 25.4 4.9 1.1e-05 25.4 4.9 2.2 2 1 0 2 2 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 EDO19363.1 - 2.8e-05 23.9 6.2 2.8e-05 23.9 6.2 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EDO19363.1 - 5e-05 23.5 7.1 5e-05 23.5 7.1 2.3 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 EDO19363.1 - 5.1e-05 23.1 8.2 5.1e-05 23.1 8.2 2.5 3 0 0 3 3 2 1 zinc-RING finger domain Cep57_MT_bd PF06657.13 EDO19363.1 - 0.0013 19.1 11.0 0.023 15.1 3.9 2.6 1 1 1 2 2 2 2 Centrosome microtubule-binding domain of Cep57 Prok-RING_4 PF14447.6 EDO19363.1 - 0.0062 16.4 11.4 0.0062 16.4 11.4 3.2 2 2 1 3 3 3 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 EDO19363.1 - 0.01 15.9 4.2 0.01 15.9 4.2 2.1 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger RRM_2 PF04059.12 EDO19363.1 - 0.013 15.7 0.3 0.053 13.7 0.3 2.0 2 0 0 2 2 2 0 RNA recognition motif 2 DUF1664 PF07889.12 EDO19363.1 - 0.017 15.2 6.4 0.048 13.7 6.4 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Baculo_PEP_C PF04513.12 EDO19363.1 - 0.025 14.6 5.1 0.049 13.7 5.1 1.4 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus HALZ PF02183.18 EDO19363.1 - 0.035 14.3 0.6 0.035 14.3 0.6 4.0 4 0 0 4 4 4 0 Homeobox associated leucine zipper zf-RING_4 PF14570.6 EDO19363.1 - 0.045 13.5 8.0 0.12 12.2 8.0 1.7 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain DUF4407 PF14362.6 EDO19363.1 - 0.051 12.9 5.8 0.077 12.3 5.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF4600 PF15372.6 EDO19363.1 - 0.14 12.5 13.1 4 7.9 8.0 2.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4600) UPF0242 PF06785.11 EDO19363.1 - 0.35 10.9 13.9 0.83 9.7 13.9 1.6 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus KLRAQ PF10205.9 EDO19363.1 - 0.63 10.3 12.1 0.55 10.5 9.6 2.2 1 1 1 2 2 2 0 Predicted coiled-coil domain-containing protein Gmx_para_CXXCG PF09535.10 EDO19363.1 - 0.73 9.1 2.5 1.3 8.2 2.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (Gmx_para_CXXCG) OmpH PF03938.14 EDO19363.1 - 0.99 9.7 11.1 1.9 8.8 11.1 1.4 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) FlaC_arch PF05377.11 EDO19363.1 - 1.2 9.6 7.5 2.1 8.8 0.7 3.1 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) Exonuc_VII_L PF02601.15 EDO19363.1 - 1.5 8.3 7.0 2.2 7.7 7.0 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Form_Nir_trans PF01226.17 EDO19364.1 - 6.6e-60 202.4 20.9 8.1e-60 202.1 20.9 1.1 1 0 0 1 1 1 1 Formate/nitrite transporter Cnd1 PF12717.7 EDO19365.1 - 1.6e-05 25.0 4.3 1.6e-05 25.0 4.3 4.9 5 2 0 5 5 5 1 non-SMC mitotic condensation complex subunit 1 PHD PF00628.29 EDO19366.1 - 4.4e-15 55.3 19.6 4.9e-11 42.3 7.2 3.1 2 1 1 3 3 3 2 PHD-finger zf-HC5HC2H PF13771.6 EDO19366.1 - 0.0016 18.6 0.6 0.0016 18.6 0.6 2.6 2 0 0 2 2 2 1 PHD-like zinc-binding domain PHD_4 PF16866.5 EDO19366.1 - 0.013 15.6 1.7 0.013 15.6 1.7 2.9 2 0 0 2 2 2 0 PHD-finger C1_1 PF00130.22 EDO19366.1 - 0.021 14.7 10.0 0.23 11.4 0.5 2.5 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) PHD_2 PF13831.6 EDO19366.1 - 1.2 8.8 10.5 1.5 8.4 0.3 3.2 3 0 0 3 3 3 0 PHD-finger dsDNA_bind PF01984.20 EDO19367.1 - 4.5e-24 84.9 0.0 6.3e-24 84.4 0.0 1.2 1 0 0 1 1 1 1 Double-stranded DNA-binding domain HemS PF05171.12 EDO19367.1 - 0.094 12.7 0.0 0.13 12.2 0.0 1.2 1 0 0 1 1 1 0 Haemin-degrading HemS.ChuX domain DNA_pol_phi PF04931.13 EDO19367.1 - 0.13 10.4 3.0 0.16 10.0 3.0 1.2 1 0 0 1 1 1 0 DNA polymerase phi GDC-P PF02347.16 EDO19368.1 - 3.1e-193 642.5 0.0 3.4e-182 606.1 0.0 2.7 2 1 0 2 2 2 2 Glycine cleavage system P-protein Cys_Met_Meta_PP PF01053.20 EDO19368.1 - 4.6e-05 22.1 0.1 0.0046 15.5 0.0 3.0 3 0 0 3 3 3 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 EDO19368.1 - 8.1e-05 21.7 0.0 0.00021 20.4 0.1 1.6 2 0 0 2 2 2 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 EDO19368.1 - 0.038 13.3 0.0 0.063 12.5 0.0 1.3 1 0 0 1 1 1 0 Beta-eliminating lyase Ribosomal_S17 PF00366.20 EDO19369.1 - 3.2e-23 81.6 1.2 4.6e-23 81.1 0.2 1.8 2 0 0 2 2 2 1 Ribosomal protein S17 Rhomboid PF01694.22 EDO19370.1 - 1.1e-19 70.9 11.3 1.1e-19 70.9 11.3 1.4 2 0 0 2 2 2 1 Rhomboid family DUF5408 PF17402.2 EDO19370.1 - 3.4 7.6 4.5 14 5.6 0.7 2.6 2 0 0 2 2 2 0 Family of unknown function (DUF5408) DUF2070 PF09843.9 EDO19370.1 - 5.8 5.1 10.5 8.7 4.5 10.5 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) HSP90 PF00183.18 EDO19371.1 - 1.1e-218 727.4 36.8 1.4e-218 727.1 36.8 1.1 1 0 0 1 1 1 1 Hsp90 protein HATPase_c PF02518.26 EDO19371.1 - 1.7e-14 54.3 0.0 3.2e-14 53.4 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 EDO19371.1 - 2.2e-09 37.2 0.0 6.6e-09 35.7 0.0 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase RTP1_C1 PF10363.9 EDO19372.1 - 1.3e-30 105.9 0.8 1.3e-29 102.6 0.5 3.0 2 0 0 2 2 2 1 Required for nuclear transport of RNA pol II C-terminus 1 RTP1_C2 PF10304.9 EDO19372.1 - 4.3e-06 26.3 0.1 1.2e-05 24.9 0.1 1.8 1 0 0 1 1 1 1 Required for nuclear transport of RNA pol II C-terminus 2 HEAT_2 PF13646.6 EDO19372.1 - 0.1 13.0 0.0 0.89 10.0 0.0 2.4 2 0 0 2 2 2 0 HEAT repeats PMC2NT PF08066.12 EDO19372.1 - 3 8.6 10.0 0.62 10.8 4.4 2.9 2 1 1 3 3 3 0 PMC2NT (NUC016) domain AATF-Che1 PF13339.6 EDO19372.1 - 3.7 8.2 7.5 9.6 6.9 3.3 2.8 1 1 1 2 2 2 0 Apoptosis antagonizing transcription factor Ank_2 PF12796.7 EDO19373.1 - 3.6e-22 78.7 3.0 2.5e-14 53.6 0.4 2.1 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EDO19373.1 - 1.6e-16 60.2 1.6 1e-09 38.4 0.1 2.3 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 EDO19373.1 - 1e-12 48.3 0.1 2e-12 47.4 0.1 1.5 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EDO19373.1 - 1.4e-12 46.6 0.1 1.1e-05 25.4 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeat Ank PF00023.30 EDO19373.1 - 2.8e-11 43.3 0.1 6e-06 26.5 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeat Pkinase PF00069.25 EDO19375.1 - 6.3e-23 81.5 2.7 2e-18 66.7 0.5 2.4 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EDO19375.1 - 3.3e-17 62.6 0.5 1.2e-12 47.7 0.1 2.7 2 1 1 3 3 3 2 Protein tyrosine kinase Kinase-like PF14531.6 EDO19375.1 - 0.082 12.2 0.0 0.14 11.5 0.0 1.3 1 0 0 1 1 1 0 Kinase-like AceK PF06315.11 EDO19375.1 - 0.094 11.2 0.0 0.14 10.6 0.0 1.2 1 0 0 1 1 1 0 Isocitrate dehydrogenase kinase/phosphatase (AceK) SPC12 PF06645.13 EDO19376.1 - 0.28 11.3 3.1 0.15 12.1 0.8 1.7 2 0 0 2 2 2 0 Microsomal signal peptidase 12 kDa subunit (SPC12) Prominin PF05478.11 EDO19376.1 - 6.6 4.5 11.4 8.7 4.2 11.4 1.1 1 0 0 1 1 1 0 Prominin Syntaxin PF00804.25 EDO19377.1 - 3.2e-19 69.4 16.5 3.2e-19 69.4 16.5 2.6 1 1 1 2 2 2 1 Syntaxin SNARE PF05739.19 EDO19377.1 - 4.7e-12 45.7 6.5 2.1e-11 43.7 6.5 2.2 1 1 0 1 1 1 1 SNARE domain Synaptobrevin PF00957.21 EDO19377.1 - 0.0043 16.8 2.7 0.0043 16.8 2.7 2.6 2 1 0 2 2 2 1 Synaptobrevin SKA1 PF07160.12 EDO19377.1 - 0.014 15.3 3.5 0.014 15.3 3.5 2.2 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 1 DUF948 PF06103.11 EDO19377.1 - 0.031 14.5 3.6 0.031 14.5 3.6 3.0 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF948) Chordopox_A33R PF05966.12 EDO19377.1 - 0.079 12.2 0.4 3 7.1 0.1 2.3 2 0 0 2 2 2 0 Chordopoxvirus A33R protein PBP1_TM PF14812.6 EDO19377.1 - 0.15 12.4 0.0 0.15 12.4 0.0 2.4 3 1 1 4 4 4 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF745 PF05335.13 EDO19377.1 - 2.4 7.8 20.1 0.17 11.6 14.3 1.9 2 1 0 2 2 2 0 Protein of unknown function (DUF745) ACCA PF03255.14 EDO19377.1 - 3.5 7.5 9.1 0.83 9.5 1.6 2.5 2 1 0 2 2 2 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit Fas_alpha_ACP PF18325.1 EDO19378.1 - 2.2e-72 242.7 0.0 5.3e-72 241.5 0.0 1.7 1 0 0 1 1 1 1 Fatty acid synthase subunit alpha Acyl carrier domain FAS_I_H PF18314.1 EDO19378.1 - 1.5e-66 223.9 0.1 5e-66 222.2 0.1 2.0 1 0 0 1 1 1 1 Fatty acid synthase type I helical domain ketoacyl-synt PF00109.26 EDO19378.1 - 2.4e-19 69.9 0.1 5.4e-19 68.8 0.1 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain ACPS PF01648.20 EDO19378.1 - 5.1e-16 58.8 0.1 1.4e-15 57.4 0.1 1.8 1 0 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily Ketoacyl-synt_C PF02801.22 EDO19378.1 - 1.5e-13 50.8 0.0 4.3e-13 49.3 0.0 1.8 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain SPG4 PF17325.2 EDO19378.1 - 0.0097 17.0 0.2 0.074 14.2 0.0 2.5 2 0 0 2 2 2 1 Stationary phase protein 4 KR PF08659.10 EDO19378.1 - 0.013 15.4 0.0 0.038 13.9 0.0 1.8 1 0 0 1 1 1 0 KR domain zf-C2H2 PF00096.26 EDO19379.1 - 9.4e-10 38.4 9.1 0.00016 22.0 1.1 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EDO19379.1 - 3.6e-09 36.7 3.4 3.6e-09 36.7 3.4 2.4 2 0 0 2 2 2 1 Zinc-finger double domain zf-C2HE PF16278.5 EDO19379.1 - 0.00037 20.9 1.9 0.00077 19.9 1.9 1.5 1 0 0 1 1 1 1 C2HE / C2H2 / C2HC zinc-binding finger zf-H2C2_5 PF13909.6 EDO19379.1 - 0.003 17.3 2.4 1.2 8.9 0.0 2.6 2 0 0 2 2 2 2 C2H2-type zinc-finger domain zf-C2H2_4 PF13894.6 EDO19379.1 - 0.018 15.8 1.8 0.018 15.8 1.8 2.7 3 0 0 3 3 3 0 C2H2-type zinc finger zf-met PF12874.7 EDO19379.1 - 0.047 14.1 0.5 0.16 12.4 0.5 1.9 1 0 0 1 1 1 0 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 EDO19379.1 - 0.11 12.5 0.8 0.11 12.5 0.8 2.3 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_3rep PF18868.1 EDO19379.1 - 0.11 13.2 4.0 0.37 11.5 1.1 2.3 1 1 1 2 2 2 0 Zinc finger C2H2-type, 3 repeats GAGA PF09237.11 EDO19379.1 - 0.15 11.9 0.9 0.31 10.9 0.9 1.5 1 0 0 1 1 1 0 GAGA factor TFIIA PF03153.13 EDO19379.1 - 2.3 8.1 9.4 2.9 7.8 9.4 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit mRNA_triPase PF02940.15 EDO19381.1 - 1.2e-66 224.6 1.5 1.2e-66 224.6 1.5 2.1 3 0 0 3 3 3 1 mRNA capping enzyme, beta chain ABC_tran PF00005.27 EDO19383.1 - 1.8e-48 164.6 4.0 1.7e-25 90.1 0.0 4.5 3 2 0 3 3 3 2 ABC transporter SMC_N PF02463.19 EDO19383.1 - 7.4e-14 51.7 0.0 0.00033 20.2 0.0 3.7 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EDO19383.1 - 2e-13 50.9 4.8 0.0057 16.5 0.1 5.3 5 1 0 5 5 5 3 AAA domain, putative AbiEii toxin, Type IV TA system Chromo PF00385.24 EDO19383.1 - 2.6e-10 40.0 2.7 7.8e-10 38.5 2.7 1.9 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain AAA_23 PF13476.6 EDO19383.1 - 1e-08 35.9 1.3 0.0013 19.2 0.0 3.6 3 0 0 3 3 3 2 AAA domain MMR_HSR1 PF01926.23 EDO19383.1 - 6.1e-07 29.5 0.0 0.0095 16.0 0.0 3.1 3 0 0 3 3 2 2 50S ribosome-binding GTPase AAA_29 PF13555.6 EDO19383.1 - 7.2e-07 28.9 0.2 0.013 15.2 0.1 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EDO19383.1 - 1.5e-06 28.2 0.0 0.016 15.1 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase AAA_22 PF13401.6 EDO19383.1 - 2.1e-05 24.8 0.1 0.31 11.3 0.0 3.1 2 0 0 2 2 2 2 AAA domain AAA_28 PF13521.6 EDO19383.1 - 0.00035 20.9 0.0 0.29 11.4 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 EDO19383.1 - 0.00035 21.1 0.1 0.47 11.0 0.0 3.0 2 0 0 2 2 2 1 AAA domain DUF87 PF01935.17 EDO19383.1 - 0.0004 20.6 4.6 0.029 14.4 0.1 3.5 4 0 0 4 4 4 1 Helicase HerA, central domain AAA_16 PF13191.6 EDO19383.1 - 0.00041 20.8 0.9 0.19 12.1 0.0 3.2 3 0 0 3 3 3 1 AAA ATPase domain RNA_helicase PF00910.22 EDO19383.1 - 0.00041 20.7 0.1 1.6 9.1 0.0 3.0 2 0 0 2 2 2 2 RNA helicase AAA_30 PF13604.6 EDO19383.1 - 0.00055 19.7 0.1 1.8 8.2 0.0 3.8 4 1 0 4 4 3 1 AAA domain MeaB PF03308.16 EDO19383.1 - 0.0007 18.7 0.2 0.89 8.5 0.0 2.4 2 0 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB NACHT PF05729.12 EDO19383.1 - 0.00086 19.3 0.1 0.67 9.8 0.0 2.7 2 0 0 2 2 2 1 NACHT domain AAA_15 PF13175.6 EDO19383.1 - 0.0025 17.6 4.4 0.34 10.6 0.0 3.7 4 0 0 4 4 4 1 AAA ATPase domain AAA_33 PF13671.6 EDO19383.1 - 0.0037 17.4 0.0 4.6 7.4 0.0 2.9 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 EDO19383.1 - 0.0045 17.4 0.0 7.1 7.1 0.0 3.1 3 0 0 3 3 2 0 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 EDO19383.1 - 0.0069 16.4 0.0 3.2 7.8 0.0 3.2 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.6 EDO19383.1 - 0.013 15.3 0.4 1.5 8.5 0.1 3.0 3 0 0 3 3 3 0 AAA domain AAA_27 PF13514.6 EDO19383.1 - 0.013 15.1 0.1 5.8 6.4 0.0 2.5 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.22 EDO19383.1 - 0.014 14.6 0.1 0.63 9.2 0.0 2.5 2 0 0 2 2 2 0 NB-ARC domain AAA_13 PF13166.6 EDO19383.1 - 0.014 14.1 5.2 1.9 7.0 0.0 3.2 3 0 0 3 3 3 0 AAA domain PRK PF00485.18 EDO19383.1 - 0.021 14.6 0.0 36 4.0 0.0 4.2 4 0 0 4 4 4 0 Phosphoribulokinase / Uridine kinase family NTPase_1 PF03266.15 EDO19383.1 - 0.023 14.6 0.1 4.5 7.1 0.1 3.0 3 0 0 3 3 3 0 NTPase Dynamin_N PF00350.23 EDO19383.1 - 0.029 14.4 0.1 2.5 8.2 0.0 3.2 2 1 0 2 2 2 0 Dynamin family Roc PF08477.13 EDO19383.1 - 0.031 14.5 0.0 8.8 6.6 0.0 2.7 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase DUF815 PF05673.13 EDO19383.1 - 0.05 12.8 0.2 2.7 7.1 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF815) CLP1_P PF16575.5 EDO19383.1 - 0.073 12.9 0.1 7.4 6.3 0.0 2.8 2 0 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop TsaE PF02367.17 EDO19383.1 - 0.073 13.1 0.2 17 5.4 0.1 2.5 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE cobW PF02492.19 EDO19383.1 - 0.085 12.4 0.2 29 4.2 0.0 3.4 4 0 0 4 4 4 0 CobW/HypB/UreG, nucleotide-binding domain Thymidylate_kin PF02223.17 EDO19383.1 - 0.14 11.8 0.5 1.2 8.8 0.0 2.6 3 0 0 3 3 2 0 Thymidylate kinase Rad17 PF03215.15 EDO19383.1 - 0.39 10.6 0.0 0.39 10.6 0.0 2.7 3 0 0 3 3 2 0 Rad17 P-loop domain MoCF_biosynth PF00994.24 EDO19384.1 - 5.6e-33 113.6 0.0 8.7e-33 113.0 0.0 1.3 1 0 0 1 1 1 1 Probable molybdopterin binding domain GCR1_C PF12550.8 EDO19385.1 - 3.8e-22 78.4 1.1 3.8e-22 78.4 1.1 1.9 2 0 0 2 2 2 1 Transcriptional activator of glycolytic enzymes DUF1515 PF07439.11 EDO19385.1 - 0.018 15.1 0.1 0.043 13.9 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1515) UPF0061 PF02696.14 EDO19386.1 - 1.8e-160 534.7 1.2 2.4e-160 534.4 1.2 1.0 1 0 0 1 1 1 1 Uncharacterized ACR, YdiU/UPF0061 family TRP PF06011.12 EDO19387.1 - 1.2e-102 343.8 37.0 1.5e-102 343.6 37.0 1.1 1 0 0 1 1 1 1 Transient receptor potential (TRP) ion channel TRP_N PF14558.6 EDO19387.1 - 1.8e-36 125.6 0.5 5.7e-36 123.9 0.7 1.8 2 0 0 2 2 2 1 ML-like domain E1_DerP2_DerF2 PF02221.15 EDO19387.1 - 0.011 16.2 0.1 0.022 15.2 0.1 1.5 1 0 0 1 1 1 0 ML domain BNR_6 PF15899.5 EDO19388.1 - 0.0044 16.9 0.1 0.015 15.3 0.1 2.0 1 0 0 1 1 1 1 BNR-Asp box repeat Coatomer_WDAD PF04053.14 EDO19389.1 - 2.9e-169 563.8 0.6 3.7e-169 563.5 0.6 1.1 1 0 0 1 1 1 1 Coatomer WD associated region WD40 PF00400.32 EDO19389.1 - 1.4e-17 63.7 2.1 1.7e-06 28.6 0.0 5.6 6 0 0 6 6 6 3 WD domain, G-beta repeat TPR_2 PF07719.17 EDO19389.1 - 0.00032 20.6 2.2 0.72 10.1 0.1 3.8 3 1 1 4 4 4 2 Tetratricopeptide repeat Nup160 PF11715.8 EDO19389.1 - 0.00076 18.2 1.2 0.48 9.0 0.1 3.3 1 1 2 3 3 3 3 Nucleoporin Nup120/160 TPR_1 PF00515.28 EDO19389.1 - 0.00078 19.2 0.3 1.9 8.4 0.1 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 EDO19389.1 - 0.0045 17.1 1.2 1.7 9.0 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat NAD_synthase PF02540.17 EDO19389.1 - 0.02 14.0 0.0 0.033 13.3 0.0 1.3 1 0 0 1 1 1 0 NAD synthase FtsJ PF01728.19 EDO19390.1 - 5.3e-51 173.2 0.0 6.5e-51 172.9 0.0 1.1 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_23 PF13489.6 EDO19390.1 - 0.0017 18.2 0.0 0.0079 16.0 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDO19390.1 - 0.0041 16.9 0.0 2.6 7.8 0.0 2.4 2 0 0 2 2 2 2 Methyltransferase domain TetR_C_8 PF14278.6 EDO19390.1 - 0.22 11.7 1.8 1 9.5 0.1 2.5 2 1 1 3 3 3 0 Transcriptional regulator C-terminal region Ribosomal_L1 PF00687.21 EDO19391.1 - 3.4e-41 141.2 1.1 4.1e-41 141.0 1.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family Arf PF00025.21 EDO19392.1 - 2.5e-66 222.4 0.0 2.9e-66 222.3 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 EDO19392.1 - 2.8e-09 36.8 0.0 3.5e-09 36.4 0.0 1.2 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 EDO19392.1 - 3e-09 36.5 0.6 3.8e-06 26.3 0.1 2.5 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.10 EDO19392.1 - 2.8e-08 33.4 0.0 3.6e-08 33.0 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.13 EDO19392.1 - 4.7e-07 30.1 0.0 1.4e-06 28.6 0.0 1.7 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 EDO19392.1 - 4.9e-06 26.6 0.0 6.7e-06 26.2 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EDO19392.1 - 3.3e-05 23.3 0.0 3.9e-05 23.1 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EDO19392.1 - 0.00081 19.0 0.1 0.012 15.2 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain PduV-EutP PF10662.9 EDO19392.1 - 0.11 12.3 0.0 0.45 10.3 0.0 1.9 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation RIBIOP_C PF04950.12 EDO19393.1 - 5.5e-86 288.6 0.0 5.5e-86 288.6 0.0 2.5 2 1 0 2 2 1 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal AARP2CN PF08142.12 EDO19393.1 - 4.8e-29 100.3 0.0 2.5e-28 98.0 0.0 2.4 1 0 0 1 1 1 1 AARP2CN (NUC121) domain GTP_EFTU PF00009.27 EDO19393.1 - 1.5e-05 24.6 1.6 0.0029 17.2 0.0 3.0 2 1 1 3 3 2 1 Elongation factor Tu GTP binding domain AAA_16 PF13191.6 EDO19393.1 - 2.1e-05 25.0 0.0 7.1e-05 23.3 0.0 1.8 2 0 0 2 2 2 1 AAA ATPase domain AAA PF00004.29 EDO19393.1 - 4.2e-05 24.0 0.0 0.00014 22.3 0.0 2.0 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 EDO19393.1 - 8.7e-05 22.7 0.0 0.0007 19.8 0.0 2.5 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EDO19393.1 - 0.00015 22.0 0.0 0.00053 20.3 0.0 1.9 1 0 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.23 EDO19393.1 - 0.0031 17.6 0.3 0.013 15.6 0.1 2.3 2 1 0 2 2 1 1 50S ribosome-binding GTPase AAA_19 PF13245.6 EDO19393.1 - 0.0043 17.4 0.0 0.011 16.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 EDO19393.1 - 0.0048 17.3 0.0 0.017 15.5 0.0 2.0 1 0 0 1 1 1 1 RNA helicase AAA_11 PF13086.6 EDO19393.1 - 0.0066 16.3 0.1 0.0066 16.3 0.1 3.8 3 1 0 3 3 2 1 AAA domain NACHT PF05729.12 EDO19393.1 - 0.0069 16.3 0.0 0.012 15.5 0.0 1.4 1 0 0 1 1 1 1 NACHT domain ABC_tran PF00005.27 EDO19393.1 - 0.009 16.5 4.6 0.0094 16.5 0.0 2.8 2 0 0 2 2 2 1 ABC transporter AAA_30 PF13604.6 EDO19393.1 - 0.01 15.5 0.0 0.022 14.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 EDO19393.1 - 0.013 15.7 0.0 0.037 14.3 0.0 1.8 1 0 0 1 1 1 0 AAA domain cobW PF02492.19 EDO19393.1 - 0.014 14.9 0.2 0.032 13.8 0.2 1.5 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain MobB PF03205.14 EDO19393.1 - 0.022 14.6 0.3 0.076 12.9 0.1 2.0 2 0 0 2 2 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_18 PF13238.6 EDO19393.1 - 0.027 15.0 0.1 0.027 15.0 0.1 3.4 4 0 0 4 4 2 0 AAA domain AAA_5 PF07728.14 EDO19393.1 - 0.028 14.4 0.0 0.072 13.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 EDO19393.1 - 0.028 13.9 1.9 0.036 13.6 0.1 2.1 2 0 0 2 2 2 0 P-loop containing dynein motor region NTPase_1 PF03266.15 EDO19393.1 - 0.036 14.0 0.3 0.073 13.0 0.3 1.5 1 0 0 1 1 1 0 NTPase AAA_25 PF13481.6 EDO19393.1 - 0.073 12.6 0.0 0.21 11.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain PduV-EutP PF10662.9 EDO19393.1 - 0.081 12.7 0.0 1.8 8.3 0.0 2.5 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation WAC_Acf1_DNA_bd PF10537.9 EDO19394.1 - 9.9e-35 119.1 0.9 9.9e-35 119.1 0.9 2.4 2 0 0 2 2 2 1 ATP-utilising chromatin assembly and remodelling N-terminal WSD PF15613.6 EDO19394.1 - 3.5e-10 40.3 0.2 3.5e-10 40.3 0.2 3.9 3 1 0 3 3 3 1 Williams-Beuren syndrome DDT (WSD), D-TOX E motif DDT PF02791.17 EDO19394.1 - 1.7e-09 37.8 0.1 1.4e-08 34.9 0.0 2.4 2 0 0 2 2 2 1 DDT domain WHIM1 PF15612.6 EDO19394.1 - 4.1e-06 26.2 0.1 1.2e-05 24.7 0.1 1.8 1 0 0 1 1 1 1 WSTF, HB1, Itc1p, MBD9 motif 1 Ubiq_cyt_C_chap PF03981.12 EDO19395.1 - 1.9e-39 135.0 0.1 3.2e-39 134.2 0.1 1.3 1 0 0 1 1 1 1 Ubiquinol-cytochrome C chaperone HK PF02110.15 EDO19396.1 - 2.5e-84 282.5 0.2 3.9e-84 281.9 0.2 1.3 1 0 0 1 1 1 1 Hydroxyethylthiazole kinase family TMP-TENI PF02581.17 EDO19396.1 - 1.7e-55 187.1 0.0 2.7e-55 186.5 0.0 1.3 1 0 0 1 1 1 1 Thiamine monophosphate synthase LRR_9 PF14580.6 EDO19397.1 - 7e-20 71.2 0.6 1.3e-19 70.4 0.6 1.4 1 0 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.7 EDO19397.1 - 2.1e-05 24.7 11.9 0.0025 18.2 3.6 3.7 2 2 1 3 3 3 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EDO19397.1 - 0.00098 18.8 8.1 0.03 14.1 2.1 3.1 2 1 1 3 3 3 2 Leucine rich repeat LRR_6 PF13516.6 EDO19397.1 - 3.4 8.0 6.8 31 5.0 0.2 3.7 4 0 0 4 4 4 0 Leucine Rich repeat zf-HC5HC2H_2 PF13832.6 EDO19398.1 - 4.1e-15 55.9 2.7 4.1e-15 55.9 2.7 4.9 4 1 1 5 5 5 3 PHD-zinc-finger like domain BAH PF01426.18 EDO19398.1 - 1.9e-14 53.5 0.1 1.9e-14 53.5 0.1 3.1 4 0 0 4 4 4 1 BAH domain PHD PF00628.29 EDO19398.1 - 3.3e-11 42.9 52.3 1.1e-07 31.6 4.1 5.3 6 0 0 6 6 6 3 PHD-finger PHD_2 PF13831.6 EDO19398.1 - 7.3e-08 31.8 23.9 1.5e-07 30.9 1.7 4.8 4 0 0 4 4 4 2 PHD-finger zf-HC5HC2H PF13771.6 EDO19398.1 - 8e-08 32.4 1.7 8e-08 32.4 1.7 5.7 5 1 1 6 6 6 2 PHD-like zinc-binding domain C1_1 PF00130.22 EDO19398.1 - 0.1 12.5 43.4 0.039 13.8 0.7 6.1 6 0 0 6 6 6 0 Phorbol esters/diacylglycerol binding domain (C1 domain) DNA_RNApol_7kD PF03604.13 EDO19398.1 - 6 6.6 10.5 4.6 7.0 0.7 3.6 2 0 0 2 2 2 0 DNA directed RNA polymerase, 7 kDa subunit DEAD PF00270.29 EDO19399.1 - 1.5e-33 116.0 0.0 3.2e-33 115.0 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDO19399.1 - 6.4e-16 58.7 1.2 4e-14 52.9 0.1 3.2 2 1 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDO19399.1 - 8.6e-09 35.6 0.1 1.8e-08 34.6 0.1 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit SNF2_N PF00176.23 EDO19399.1 - 4.1e-06 25.8 0.0 6.6e-06 25.1 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain DUF87 PF01935.17 EDO19399.1 - 0.018 15.1 3.9 1.3 9.0 0.0 3.5 4 0 0 4 4 4 0 Helicase HerA, central domain AAA_22 PF13401.6 EDO19399.1 - 0.023 15.0 0.4 0.21 11.9 0.4 2.3 1 1 0 1 1 1 0 AAA domain UvrD_C PF13361.6 EDO19399.1 - 0.096 12.0 3.3 4.3 6.6 0.3 2.2 1 1 1 2 2 2 0 UvrD-like helicase C-terminal domain SET PF00856.28 EDO19400.1 - 1.1e-06 29.1 0.1 1.1e-06 29.1 0.1 1.8 2 1 0 2 2 2 1 SET domain YscO PF07321.12 EDO19400.1 - 0.2 11.6 0.1 0.36 10.8 0.1 1.3 1 0 0 1 1 1 0 Type III secretion protein YscO Radical_SAM PF04055.21 EDO19401.1 - 1.9e-21 77.1 0.0 4.3e-21 76.0 0.0 1.7 1 0 0 1 1 1 1 Radical SAM superfamily Wyosine_form PF08608.12 EDO19401.1 - 4.6e-21 74.9 0.0 1.5e-20 73.3 0.0 1.9 2 0 0 2 2 2 1 Wyosine base formation Flavodoxin_1 PF00258.25 EDO19401.1 - 3.1e-17 63.1 0.0 9.5e-17 61.5 0.0 1.9 1 1 0 1 1 1 1 Flavodoxin DUF3916 PF13079.6 EDO19401.1 - 0.039 13.8 0.0 0.099 12.5 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3916) Mucin15 PF15672.5 EDO19401.1 - 0.076 12.5 0.1 0.12 11.8 0.1 1.2 1 0 0 1 1 1 0 Cell-membrane associated Mucin15 Glycos_transf_1 PF00534.20 EDO19402.1 - 2.2e-36 125.0 0.1 3.1e-36 124.5 0.1 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 EDO19402.1 - 1.9e-14 54.0 0.0 2.8e-14 53.5 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_1_4 PF13692.6 EDO19402.1 - 1.3e-11 45.0 0.0 3.4e-11 43.7 0.0 1.7 1 1 0 1 1 1 1 Glycosyl transferases group 1 ALG11_N PF15924.5 EDO19402.1 - 0.084 12.9 0.6 9.1 6.3 0.6 2.9 1 1 0 1 1 1 0 ALG11 mannosyltransferase N-terminus SCA7 PF08313.12 EDO19403.1 - 8.8e-30 102.4 0.4 3.1e-29 100.7 0.4 2.0 1 0 0 1 1 1 1 SCA7, zinc-binding domain zf_C2H2_13 PF18508.1 EDO19403.1 - 1.5e-21 75.7 3.7 1.5e-21 75.7 3.7 1.8 2 0 0 2 2 2 1 Zinc finger domain Vps36-NZF-N PF16988.5 EDO19403.1 - 0.031 13.7 1.1 0.2 11.1 1.1 2.5 1 0 0 1 1 1 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain DUF4261 PF14080.6 EDO19403.1 - 0.036 14.2 0.0 1.3 9.1 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4261) Med15 PF09606.10 EDO19403.1 - 6.9 5.2 64.6 4 6.0 5.6 2.2 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal GDPD PF03009.17 EDO19404.1 - 8.8e-35 120.7 0.6 2e-34 119.5 0.6 1.5 1 1 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family 30K_MP_C_Ter PF11330.8 EDO19404.1 - 0.073 12.4 0.1 0.12 11.7 0.1 1.2 1 0 0 1 1 1 0 C-Terminal of 30K viral movement proteins NUDIX PF00293.28 EDO19405.1 - 7e-13 48.8 0.0 1.1e-12 48.2 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain zf-NADH-PPase PF09297.11 EDO19405.1 - 2.1e-05 24.1 0.3 5.5e-05 22.7 0.3 1.7 1 0 0 1 1 1 1 NADH pyrophosphatase zinc ribbon domain NUDIX-like PF09296.11 EDO19405.1 - 0.00036 21.1 0.0 0.0006 20.4 0.0 1.4 1 0 0 1 1 1 1 NADH pyrophosphatase-like rudimentary NUDIX domain gpUL132 PF11359.8 EDO19405.1 - 0.02 14.4 0.0 0.045 13.3 0.0 1.5 1 0 0 1 1 1 0 Glycoprotein UL132 IBR PF01485.21 EDO19405.1 - 0.1 12.8 0.4 0.1 12.8 0.4 2.1 2 0 0 2 2 2 0 IBR domain, a half RING-finger domain Pkinase PF00069.25 EDO19406.1 - 1.5e-23 83.5 0.0 2.5e-23 82.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO19406.1 - 9e-14 51.4 0.0 1.4e-13 50.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EDO19406.1 - 8.8e-09 34.6 0.0 8.8e-09 34.6 0.0 1.6 2 0 0 2 2 2 1 Fungal protein kinase Ribosomal_L12 PF00542.19 EDO19407.1 - 1.1e-21 76.9 10.7 1.9e-21 76.2 6.3 2.3 2 0 0 2 2 2 1 Ribosomal protein L7/L12 C-terminal domain Ribosomal_L12_N PF16320.5 EDO19407.1 - 4.7e-15 55.0 6.0 4.7e-15 55.0 6.0 3.3 3 0 0 3 3 3 2 Ribosomal protein L7/L12 dimerisation domain Ribosomal_60s PF00428.19 EDO19407.1 - 0.027 15.1 8.9 0.027 15.1 8.9 2.9 1 1 1 3 3 3 0 60s Acidic ribosomal protein KxDL PF10241.9 EDO19408.1 - 9e-23 80.4 2.9 1.5e-22 79.7 2.9 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein Adaptin_N PF01602.20 EDO19409.1 - 3.5e-115 385.5 12.7 4.3e-115 385.2 12.7 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 EDO19409.1 - 6.9e-11 42.4 0.3 6.9e-11 42.4 0.3 2.9 3 0 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EDO19409.1 - 2.8e-05 24.4 0.2 0.018 15.4 0.0 3.9 2 1 3 5 5 5 1 HEAT repeats Cnd3 PF12719.7 EDO19409.1 - 0.0027 17.0 1.8 0.51 9.5 0.1 3.2 3 0 0 3 3 3 1 Nuclear condensing complex subunits, C-term domain Vac14_Fab1_bd PF12755.7 EDO19409.1 - 0.0042 17.6 1.7 0.13 12.9 0.3 3.6 3 0 0 3 3 3 1 Vacuolar 14 Fab1-binding region RTP1_C1 PF10363.9 EDO19409.1 - 0.051 13.8 0.2 3.2 8.0 0.1 3.2 3 0 0 3 3 3 0 Required for nuclear transport of RNA pol II C-terminus 1 HEAT PF02985.22 EDO19409.1 - 0.094 13.0 1.3 73 4.0 0.0 4.8 5 0 0 5 5 5 0 HEAT repeat Yae1_N PF09811.9 EDO19409.1 - 0.15 11.8 0.3 0.34 10.6 0.3 1.6 1 0 0 1 1 1 0 Essential protein Yae1, N terminal Rad9 PF04139.13 EDO19410.1 - 2.1e-08 33.9 6.2 1.5e-06 27.9 6.2 2.5 1 1 0 1 1 1 1 Rad9 NUFIP1 PF10453.9 EDO19411.1 - 5.1e-19 67.9 0.7 5.1e-19 67.9 0.7 3.1 3 0 0 3 3 3 1 Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1) SpoIISA_toxin PF14171.6 EDO19411.1 - 3.9 7.1 8.7 0.061 13.0 1.2 1.8 2 0 0 2 2 2 0 Toxin SpoIISA, type II toxin-antitoxin system DUF4934 PF16288.5 EDO19411.1 - 7.8 6.5 7.7 19 5.2 0.2 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4934) UPF0524 PF15823.5 EDO19411.1 - 9.5 5.5 9.5 97 2.2 9.4 2.2 1 1 0 1 1 1 0 UPF0524 of C3orf70 MINDY_DUB PF04424.13 EDO19412.1 - 1.2e-30 105.9 0.2 3.1e-30 104.6 0.1 1.7 2 0 0 2 2 2 1 MINDY deubiquitinase Transglut_i_TM PF14400.6 EDO19412.1 - 0.0001 22.4 1.1 0.00016 21.8 1.1 1.3 1 0 0 1 1 1 1 Inactive transglutaminase fused to 7 transmembrane helices Nab1 PF04902.12 EDO19412.1 - 0.0037 17.7 2.0 0.0066 16.9 2.0 1.3 1 0 0 1 1 1 1 Conserved region in Nab1 Molybdopterin PF00384.22 EDO19413.1 - 0.024 13.6 0.1 0.036 13.0 0.1 1.2 1 0 0 1 1 1 0 Molybdopterin oxidoreductase Ibs_toxin PF13956.6 EDO19413.1 - 0.32 11.1 1.7 0.64 10.1 1.7 1.4 1 0 0 1 1 1 0 Toxin Ibs, type I toxin-antitoxin system Pkinase PF00069.25 EDO19414.1 - 2.6e-23 82.7 0.1 4.9e-23 81.8 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO19414.1 - 9e-14 51.4 0.0 1.6e-13 50.5 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase EF-G-binding_N PF07299.11 EDO19414.1 - 0.031 14.8 1.1 0.4 11.2 0.0 3.2 3 0 0 3 3 3 0 Elongation factor G-binding protein, N-terminal MBOAT PF03062.19 EDO19415.1 - 2.3e-70 237.7 17.1 2.3e-70 237.7 17.1 1.5 1 1 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family SNase PF00565.17 EDO19416.1 - 4.9e-25 88.1 0.0 7.7e-25 87.5 0.0 1.3 1 0 0 1 1 1 1 Staphylococcal nuclease homologue DUF3149 PF11346.8 EDO19416.1 - 0.13 11.9 0.0 0.34 10.6 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3149) MAD PF05557.13 EDO19417.1 - 8.6e-23 80.6 89.2 5.4e-21 74.6 89.2 2.6 1 1 0 1 1 1 1 Mitotic checkpoint protein Phage_GP20 PF06810.11 EDO19417.1 - 0.0097 15.7 5.4 0.0097 15.7 5.4 6.4 3 2 1 4 4 4 1 Phage minor structural protein GP20 HALZ PF02183.18 EDO19417.1 - 2.2 8.6 0.0 2.2 8.6 0.0 9.1 7 2 0 7 7 7 0 Homeobox associated leucine zipper UQ_con PF00179.26 EDO19418.1 - 1.6e-16 60.2 0.1 1.8e-16 60.0 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 EDO19418.1 - 0.0016 18.7 0.0 0.0018 18.5 0.0 1.2 1 0 0 1 1 1 1 RWD domain NAD_kinase PF01513.21 EDO19419.1 - 7.9e-54 182.8 0.0 1e-53 182.4 0.0 1.1 1 0 0 1 1 1 1 ATP-NAD kinase DAGK_cat PF00781.24 EDO19419.1 - 0.0073 15.9 0.0 0.013 15.1 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain Viral_DNA_bp PF00747.17 EDO19419.1 - 0.14 9.2 0.1 0.23 8.6 0.1 1.2 1 0 0 1 1 1 0 ssDNA binding protein MF_alpha PF04648.12 EDO19420.1 - 2.4e-38 128.9 37.8 3.2e-07 30.4 1.7 5.3 5 0 0 5 5 5 5 Yeast mating factor alpha hormone MF_alpha_N PF05436.11 EDO19420.1 - 7.7e-32 109.1 3.8 1.2e-31 108.5 3.8 1.3 1 0 0 1 1 1 1 Mating factor alpha precursor N-terminus WW_1 PF18507.1 EDO19420.1 - 0.00018 21.1 0.2 84 3.0 0.0 5.2 5 0 0 5 5 5 0 WW domain Sld5 PF05916.11 EDO19420.1 - 0.03 14.8 2.0 1.1 9.8 0.6 3.0 1 1 1 2 2 2 0 GINS complex protein CG-1 PF03859.16 EDO19420.1 - 0.054 13.3 2.9 9.4 6.1 0.2 3.1 2 1 1 3 3 3 0 CG-1 domain TFIIIC_sub6 PF10419.9 EDO19420.1 - 0.061 13.2 0.0 5.2 7.0 0.0 3.2 1 1 1 2 2 2 0 TFIIIC subunit triple barrel domain Vac_ImportDeg PF09783.9 EDO19420.1 - 0.19 11.5 6.8 1.7 8.5 0.2 2.9 1 1 1 2 2 2 0 Vacuolar import and degradation protein Cu_amine_oxidN2 PF02727.16 EDO19420.1 - 3.6 7.9 10.2 68 3.8 0.1 4.7 2 1 4 6 6 6 0 Copper amine oxidase, N2 domain AMPK1_CBM PF16561.5 EDO19421.1 - 2.4e-06 27.7 0.5 5e-06 26.6 0.5 1.5 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase DUF5484 PF17583.2 EDO19421.1 - 0.56 9.9 4.9 0.19 11.4 0.8 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5484) TAF1D PF15333.6 EDO19421.1 - 6.4 6.5 11.0 0.21 11.3 1.5 2.6 2 1 1 3 3 3 0 TATA box-binding protein-associated factor 1D RRM_1 PF00076.22 EDO19422.1 - 8.2e-25 86.4 0.8 2e-08 34.0 0.1 4.8 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EDO19422.1 - 4.9e-13 48.7 0.1 0.05 13.5 0.0 4.5 4 0 0 4 4 4 4 Occluded RNA-recognition motif RRM_5 PF13893.6 EDO19422.1 - 1e-05 25.1 0.2 0.035 13.7 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 EDO19422.1 - 0.21 11.6 0.3 0.57 10.3 0.0 1.8 2 0 0 2 2 2 0 RNA binding motif ParA PF10609.9 EDO19424.1 - 1.8e-92 309.3 0.0 2.1e-92 309.0 0.0 1.0 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 EDO19424.1 - 9.9e-08 32.1 0.0 6.9e-07 29.4 0.0 2.2 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 EDO19424.1 - 8.1e-07 29.1 0.5 2.2e-05 24.5 0.5 2.2 1 1 0 1 1 1 1 AAA domain ArsA_ATPase PF02374.15 EDO19424.1 - 0.00019 20.7 0.6 0.006 15.8 0.1 2.7 2 1 1 3 3 3 1 Anion-transporting ATPase MipZ PF09140.11 EDO19424.1 - 0.00033 20.0 0.0 0.00053 19.4 0.0 1.3 1 1 0 1 1 1 1 ATPase MipZ RsgA_GTPase PF03193.16 EDO19424.1 - 0.0085 16.0 0.0 0.018 15.0 0.0 1.5 1 0 0 1 1 1 1 RsgA GTPase TF_Zn_Ribbon PF08271.12 EDO19424.1 - 0.022 14.3 0.5 0.046 13.2 0.5 1.6 1 0 0 1 1 1 0 TFIIB zinc-binding CBP_BcsQ PF06564.12 EDO19424.1 - 0.046 13.2 0.1 0.093 12.2 0.1 1.6 1 1 0 1 1 1 0 Cellulose biosynthesis protein BcsQ AAA_25 PF13481.6 EDO19424.1 - 0.056 13.0 0.0 0.089 12.4 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_15 PF13175.6 EDO19424.1 - 0.087 12.5 0.0 0.11 12.2 0.0 1.1 1 0 0 1 1 1 0 AAA ATPase domain TsaE PF02367.17 EDO19424.1 - 0.2 11.6 0.0 0.37 10.8 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Spc7 PF08317.11 EDO19425.1 - 1.2e-70 237.9 19.0 1.2e-70 237.9 19.0 2.4 2 0 0 2 2 2 1 Spc7 kinetochore protein Spc7_C2 PF15577.6 EDO19425.1 - 1e-09 38.3 0.7 2.6e-09 37.0 0.7 1.7 1 0 0 1 1 1 1 Spc7_C2 RhoGEF67_u1 PF16615.5 EDO19425.1 - 0.059 13.9 0.1 0.42 11.2 0.1 2.5 1 0 0 1 1 1 0 Unstructured region one on RhoGEF 6 and 7 BLOC1_2 PF10046.9 EDO19425.1 - 1.2 9.5 13.1 4.8 7.6 2.8 3.5 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 TPR_MLP1_2 PF07926.12 EDO19425.1 - 1.4 9.0 12.8 14 5.7 11.5 2.9 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein Tup_N PF08581.10 EDO19425.1 - 3.6 8.0 18.1 0.043 14.1 5.5 3.5 2 1 1 3 3 3 0 Tup N-terminal DUF1664 PF07889.12 EDO19425.1 - 5.2 7.1 17.1 2.9 7.9 3.3 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) DUF4047 PF13256.6 EDO19425.1 - 7.2 6.8 9.6 1.3 9.3 2.6 3.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4047) Ribosomal_L36 PF00444.18 EDO19426.1 - 1.8e-19 69.6 10.3 2.6e-19 69.1 10.3 1.2 1 0 0 1 1 1 1 Ribosomal protein L36 Crust_neurohorm PF01147.17 EDO19426.1 - 0.056 13.3 1.2 0.089 12.6 1.2 1.3 1 0 0 1 1 1 0 Crustacean CHH/MIH/GIH neurohormone family WD40 PF00400.32 EDO19427.1 - 2.4e-18 66.2 19.0 1.1e-06 29.2 0.3 8.4 9 0 0 9 9 9 4 WD domain, G-beta repeat YmzC PF14157.6 EDO19427.1 - 0.075 13.1 0.0 1.4 9.0 0.0 2.6 2 0 0 2 2 2 0 YmzC-like protein DUF4388 PF14332.6 EDO19427.1 - 0.18 12.1 0.0 0.45 10.8 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4388) DUF2222 PF09984.9 EDO19427.1 - 0.19 11.6 0.1 0.4 10.5 0.1 1.4 1 0 0 1 1 1 0 Uncharacterised signal transduction histidine kinase domain (DUF2222) TCO89 PF10452.9 EDO19428.1 - 1e-263 876.8 56.8 1.4e-263 876.3 56.8 1.2 1 0 0 1 1 1 1 TORC1 subunit TCO89 Sec1 PF00995.23 EDO19429.1 - 2.1e-119 400.3 17.5 2.4e-119 400.2 17.5 1.0 1 0 0 1 1 1 1 Sec1 family tRNA_NucTran2_2 PF13735.6 EDO19429.1 - 1.1 9.2 4.4 8.6 6.3 0.0 3.6 4 1 1 5 5 5 0 tRNA nucleotidyltransferase domain 2 putative PHD PF00628.29 EDO19430.1 - 2.6e-11 43.2 6.7 4.8e-11 42.4 6.7 1.5 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 EDO19430.1 - 0.12 11.9 5.5 0.2 11.2 5.5 1.4 1 0 0 1 1 1 0 PHD-finger RT_RNaseH_2 PF17919.1 EDO19431.1 - 4.5e-10 39.5 0.0 5.7e-10 39.1 0.0 1.1 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 EDO19431.1 - 1.1e-05 25.6 0.0 1.5e-05 25.2 0.0 1.2 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RRM_1 PF00076.22 EDO19432.1 - 3.5e-15 55.6 0.0 5.5e-15 54.9 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DAHP_synth_1 PF00793.20 EDO19433.1 - 2.1e-109 364.7 0.0 2.5e-109 364.4 0.0 1.0 1 0 0 1 1 1 1 DAHP synthetase I family RCC1 PF00415.18 EDO19434.1 - 1.2e-62 208.3 0.0 8.4e-10 39.1 0.0 7.3 7 0 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EDO19434.1 - 1.9e-38 129.5 18.4 7.2e-08 32.0 0.0 7.3 7 0 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat MMR_HSR1 PF01926.23 EDO19435.1 - 1.1e-16 60.9 0.3 1.3e-14 54.2 0.0 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EDO19435.1 - 7.2e-08 32.1 0.2 5.6e-06 26.0 0.0 2.3 2 0 0 2 2 2 2 Ferrous iron transport protein B RsgA_GTPase PF03193.16 EDO19435.1 - 5.7e-06 26.3 0.9 0.0059 16.5 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase Dynamin_N PF00350.23 EDO19435.1 - 0.0024 18.0 1.6 0.041 13.9 0.5 3.0 2 1 0 2 2 2 1 Dynamin family AIG1 PF04548.16 EDO19435.1 - 0.004 16.5 0.1 0.0091 15.3 0.1 1.6 1 0 0 1 1 1 1 AIG1 family Beach PF02138.18 EDO19436.1 - 0.12 11.7 0.0 0.2 11.0 0.0 1.3 1 0 0 1 1 1 0 Beige/BEACH domain SNF2_N PF00176.23 EDO19437.1 - 1.3e-71 241.1 1.5 5.6e-71 239.1 1.5 1.9 1 1 0 1 1 1 1 SNF2 family N-terminal domain SLIDE PF09111.10 EDO19437.1 - 2.8e-39 133.7 0.9 2.8e-39 133.7 0.9 4.2 4 0 0 4 4 4 1 SLIDE HAND PF09110.11 EDO19437.1 - 3.4e-30 105.0 1.9 3.4e-30 105.0 1.9 4.5 4 0 0 4 4 4 1 HAND Helicase_C PF00271.31 EDO19437.1 - 1.3e-19 70.5 0.0 6.6e-19 68.3 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDO19437.1 - 1.7e-08 34.7 0.0 1.7e-08 34.7 0.0 3.9 5 0 0 5 5 5 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EDO19437.1 - 0.00037 20.3 0.0 0.001 18.9 0.0 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_14 PF13173.6 EDO19437.1 - 0.055 13.5 0.6 0.28 11.2 0.1 2.6 2 0 0 2 2 2 0 AAA domain GSHPx PF00255.19 EDO19438.1 - 3.3e-49 165.0 0.2 4.4e-49 164.6 0.2 1.1 1 0 0 1 1 1 1 Glutathione peroxidase AhpC-TSA PF00578.21 EDO19438.1 - 5.4e-05 23.1 0.0 0.00028 20.8 0.0 2.0 1 1 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 EDO19438.1 - 0.0015 18.3 0.0 0.003 17.3 0.0 1.7 1 1 0 1 1 1 1 Redoxin Img2 PF05046.14 EDO19438.1 - 0.15 12.4 0.0 2.5 8.5 0.0 2.2 2 0 0 2 2 2 0 Mitochondrial large subunit ribosomal protein (Img2) HD_3 PF13023.6 EDO19439.1 - 6.9e-37 126.9 0.3 9.6e-37 126.4 0.3 1.2 1 0 0 1 1 1 1 HD domain HD_2 PF12917.7 EDO19439.1 - 1.4e-09 38.0 0.3 1.8e-09 37.6 0.3 1.2 1 0 0 1 1 1 1 HD containing hydrolase-like enzyme HD PF01966.22 EDO19439.1 - 1.8e-06 28.2 0.1 2.8e-06 27.5 0.1 1.3 1 0 0 1 1 1 1 HD domain Ribosomal_L27A PF00828.19 EDO19440.1 - 2.1e-22 80.2 0.2 3e-22 79.6 0.0 1.3 1 1 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A tRNA_bind PF01588.20 EDO19441.1 - 3.3e-28 97.6 0.0 6.1e-28 96.8 0.0 1.5 1 0 0 1 1 1 1 Putative tRNA binding domain DUF913 PF06025.12 EDO19441.1 - 0.18 10.7 1.6 0.26 10.2 1.6 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) SAPS PF04499.15 EDO19441.1 - 0.23 10.2 4.8 0.32 9.7 4.8 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Sigma70_ner PF04546.13 EDO19441.1 - 1.3 8.9 14.1 0.12 12.2 9.5 1.6 2 0 0 2 2 2 0 Sigma-70, non-essential region RR_TM4-6 PF06459.12 EDO19441.1 - 1.5 8.6 10.7 2.6 7.8 10.7 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Presenilin PF01080.17 EDO19441.1 - 4 6.1 5.6 6.1 5.5 5.6 1.2 1 0 0 1 1 1 0 Presenilin TAF4 PF05236.14 EDO19441.1 - 5 6.8 14.1 7.5 6.2 14.1 1.2 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family NARP1 PF12569.8 EDO19441.1 - 8.6 5.1 17.2 14 4.4 17.2 1.2 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 EF-hand_7 PF13499.6 EDO19442.1 - 1.6e-10 41.3 1.9 1.3e-08 35.2 0.7 2.2 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_9 PF14658.6 EDO19442.1 - 6.5e-10 39.2 0.1 0.0013 19.0 0.0 2.5 2 1 1 3 3 3 2 EF-hand domain EF-hand_8 PF13833.6 EDO19442.1 - 3.1e-09 36.6 0.2 9.1e-08 31.8 0.2 2.7 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_1 PF00036.32 EDO19442.1 - 4.9e-08 32.0 7.6 0.00016 21.0 0.1 3.8 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 EDO19442.1 - 9.8e-08 31.3 5.6 0.00015 21.4 0.1 3.9 4 1 1 5 5 5 2 EF-hand domain TFIID_30kDa PF03540.13 EDO19442.1 - 0.038 13.9 0.4 1.2 9.2 0.0 2.4 2 0 0 2 2 2 0 Transcription initiation factor TFIID 23-30kDa subunit LisH_2 PF16045.5 EDO19442.1 - 0.11 11.5 0.0 0.2 10.7 0.0 1.3 1 0 0 1 1 1 0 LisH CUE PF02845.16 EDO19445.1 - 1.8e-07 30.7 0.7 4.6e-07 29.4 0.7 1.8 1 0 0 1 1 1 1 CUE domain WD40 PF00400.32 EDO19446.1 - 1.2e-10 41.7 12.0 0.0027 18.5 0.5 6.4 7 0 0 7 7 7 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDO19446.1 - 1.4e-09 38.2 0.8 0.026 14.8 0.0 5.3 4 2 1 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EDO19446.1 - 0.0076 16.1 0.1 0.29 11.0 0.0 2.5 2 0 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A Hira PF07569.11 EDO19446.1 - 0.013 15.3 0.0 0.025 14.3 0.0 1.4 1 0 0 1 1 1 0 TUP1-like enhancer of split DUF5074 PF16819.5 EDO19446.1 - 0.087 12.9 0.2 0.39 10.8 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF5074) DASH_Dad3 PF08656.10 EDO19447.1 - 2e-27 95.1 1.4 2.3e-27 94.9 1.4 1.0 1 0 0 1 1 1 1 DASH complex subunit Dad3 BLOC1_2 PF10046.9 EDO19447.1 - 0.032 14.5 0.1 0.048 14.0 0.1 1.2 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 TAF6_C PF07571.13 EDO19448.1 - 1.3e-29 102.3 0.0 3e-29 101.2 0.0 1.6 1 0 0 1 1 1 1 TAF6 C-terminal HEAT repeat domain TAF PF02969.17 EDO19448.1 - 2.6e-28 98.0 0.2 5.6e-28 96.9 0.2 1.6 1 0 0 1 1 1 1 TATA box binding protein associated factor (TAF) Histone PF00125.24 EDO19448.1 - 0.0015 18.9 0.7 0.041 14.3 0.1 2.3 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 TFIID-31kDa PF02291.15 EDO19448.1 - 0.0051 16.9 0.0 0.014 15.5 0.0 1.7 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit DUF348 PF03990.14 EDO19448.1 - 0.012 15.3 0.0 0.047 13.4 0.0 2.0 1 0 0 1 1 1 0 G5-linked-Ubiquitin-like domain CENP-S PF15630.6 EDO19448.1 - 0.024 15.0 0.9 5.3 7.5 0.0 2.9 3 0 0 3 3 3 0 CENP-S protein TAF4 PF05236.14 EDO19448.1 - 0.034 13.9 0.0 0.063 13.0 0.0 1.4 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family CBFD_NFYB_HMF PF00808.23 EDO19448.1 - 0.037 14.3 0.2 0.12 12.7 0.1 2.0 2 0 0 2 2 2 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Tantalus PF15386.6 EDO19448.1 - 0.072 13.2 0.2 0.23 11.6 0.2 1.8 1 0 0 1 1 1 0 Drosophila Tantalus-like LZ3wCH PF18517.1 EDO19448.1 - 0.08 13.1 0.0 0.32 11.1 0.0 2.0 2 0 0 2 2 2 0 Leucine zipper with capping helix domain SLD3 PF08639.10 EDO19449.1 - 1e-44 153.3 28.9 6.1e-32 111.1 22.3 2.1 1 1 0 2 2 2 2 DNA replication regulator SLD3 Sld3_N PF18523.1 EDO19449.1 - 6.1e-19 68.2 1.3 2.3e-18 66.4 1.3 2.0 1 0 0 1 1 1 1 Sld3 N-terminal domain BCNT PF07572.12 EDO19450.1 - 2.1e-24 85.4 0.2 2.1e-24 85.4 0.2 2.6 3 0 0 3 3 3 1 Bucentaur or craniofacial development OPT PF03169.15 EDO19451.1 - 2.2e-152 508.9 22.2 2.5e-152 508.7 22.2 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein DUF4235 PF14019.6 EDO19451.1 - 0.22 11.6 4.4 0.69 10.0 0.2 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF4235) Claudin_2 PF13903.6 EDO19451.1 - 5.1 6.8 8.5 0.91 9.2 0.4 3.1 3 0 0 3 3 3 0 PMP-22/EMP/MP20/Claudin tight junction CBS PF00571.28 EDO19452.1 - 5e-26 90.9 3.1 2.3e-10 40.7 0.0 4.4 4 0 0 4 4 4 4 CBS domain HTH_9 PF08221.11 EDO19452.1 - 0.28 11.3 1.5 3.2 7.9 0.1 3.1 4 0 0 4 4 4 0 RNA polymerase III subunit RPC82 helix-turn-helix domain ANAPC4_WD40 PF12894.7 EDO19453.1 - 5.6e-14 52.2 4.2 3.4e-05 24.1 0.1 4.5 2 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EDO19453.1 - 1.7e-13 50.7 10.0 0.00025 21.8 0.2 5.5 5 0 0 5 5 5 4 WD domain, G-beta repeat Ge1_WD40 PF16529.5 EDO19453.1 - 1.1e-08 34.4 0.1 6.2e-05 22.1 0.0 3.7 2 1 2 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein YlbE PF14003.6 EDO19454.1 - 0.011 16.1 0.0 0.026 15.0 0.0 1.7 1 0 0 1 1 1 0 YlbE-like protein Imm3 PF14425.6 EDO19454.1 - 0.043 13.9 0.2 0.22 11.6 0.1 2.2 2 0 0 2 2 2 0 Immunity protein Imm3 Aminotran_1_2 PF00155.21 EDO19455.1 - 3e-68 230.6 0.0 3.6e-68 230.4 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 EDO19455.1 - 0.0009 18.3 0.0 0.0014 17.6 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V OKR_DC_1 PF01276.20 EDO19455.1 - 0.12 11.1 0.0 0.18 10.5 0.0 1.1 1 0 0 1 1 1 0 Orn/Lys/Arg decarboxylase, major domain ABC_tran PF00005.27 EDO19456.1 - 5.1e-26 91.8 0.1 2e-15 57.5 0.0 3.0 3 0 0 3 3 3 2 ABC transporter AAA_21 PF13304.6 EDO19456.1 - 8.1e-06 25.9 5.9 0.037 13.8 0.1 3.1 2 2 1 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system SbcCD_C PF13558.6 EDO19456.1 - 6.3e-05 23.1 0.2 0.013 15.7 0.0 2.8 3 0 0 3 3 3 1 Putative exonuclease SbcCD, C subunit AAA_29 PF13555.6 EDO19456.1 - 0.0032 17.2 0.1 0.0082 15.9 0.1 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_23 PF13476.6 EDO19456.1 - 0.016 15.7 1.0 0.039 14.5 1.0 1.8 1 1 0 1 1 1 0 AAA domain AAA_22 PF13401.6 EDO19456.1 - 0.029 14.6 0.3 1.9 8.7 0.1 3.0 2 1 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 EDO19456.1 - 0.03 14.4 0.0 0.066 13.3 0.0 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase SMC_N PF02463.19 EDO19456.1 - 0.11 11.9 0.1 0.28 10.6 0.1 1.7 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain GDI PF00996.18 EDO19457.1 - 7.9e-224 743.0 0.6 1e-223 742.7 0.6 1.0 1 0 0 1 1 1 1 GDP dissociation inhibitor NAD_binding_8 PF13450.6 EDO19457.1 - 0.0076 16.5 0.1 0.015 15.5 0.1 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain zf-C2H2_10 PF16588.5 EDO19458.1 - 7.1e-15 54.4 3.4 1.1e-14 53.8 3.4 1.3 1 0 0 1 1 1 1 C2H2 zinc-finger zf-CCHC PF00098.23 EDO19458.1 - 0.017 15.2 1.0 0.024 14.7 1.0 1.2 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_4 PF14392.6 EDO19458.1 - 0.048 13.4 1.1 0.048 13.4 1.1 1.7 2 0 0 2 2 2 0 Zinc knuckle PHD_4 PF16866.5 EDO19458.1 - 0.057 13.5 0.4 0.12 12.5 0.4 1.5 1 0 0 1 1 1 0 PHD-finger DUF1542 PF07564.11 EDO19458.1 - 1.6 8.9 15.0 0.78 9.9 2.7 2.5 2 1 0 2 2 2 0 Domain of Unknown Function (DUF1542) UAF_Rrn10 PF05234.11 EDO19459.1 - 2.1e-45 153.9 0.1 2.4e-45 153.6 0.1 1.1 1 0 0 1 1 1 1 UAF complex subunit Rrn10 Methyltr_RsmB-F PF01189.17 EDO19460.1 - 2.2e-41 141.7 0.1 9.7e-41 139.6 0.1 2.0 1 1 0 1 1 1 1 16S rRNA methyltransferase RsmB/F FtsJ PF01728.19 EDO19460.1 - 0.00023 21.3 0.2 0.00059 20.0 0.0 1.7 2 0 0 2 2 2 1 FtsJ-like methyltransferase ERF PF04404.12 EDO19460.1 - 0.0079 16.1 0.8 0.023 14.6 0.8 1.8 1 0 0 1 1 1 1 ERF superfamily LicD PF04991.13 EDO19460.1 - 0.13 12.4 0.7 0.31 11.2 0.2 1.8 2 0 0 2 2 2 0 LicD family CBFD_NFYB_HMF PF00808.23 EDO19461.1 - 1.3e-24 86.2 0.0 2.1e-24 85.6 0.0 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EDO19461.1 - 0.00012 22.4 0.0 0.00016 22.1 0.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Pax7 PF12360.8 EDO19461.1 - 0.012 15.8 1.2 0.021 15.0 1.2 1.4 1 0 0 1 1 1 0 Paired box protein 7 TFIID_20kDa PF03847.13 EDO19461.1 - 0.029 14.9 0.2 0.2 12.2 0.0 2.3 3 0 0 3 3 3 0 Transcription initiation factor TFIID subunit A PAN_3 PF08277.12 EDO19461.1 - 0.036 13.9 0.3 0.061 13.1 0.3 1.3 1 0 0 1 1 1 0 PAN-like domain CENP-T_C PF15511.6 EDO19461.1 - 0.042 14.0 0.0 0.079 13.1 0.0 1.6 1 1 0 1 1 1 0 Centromere kinetochore component CENP-T histone fold Pkinase PF00069.25 EDO19462.1 - 2.1e-69 233.8 0.0 2.7e-69 233.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO19462.1 - 3e-32 111.9 0.0 4e-32 111.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EDO19462.1 - 0.00017 20.7 2.3 0.00044 19.3 2.3 1.6 1 1 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 EDO19462.1 - 0.001 18.4 0.0 0.0016 17.8 0.0 1.3 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.22 EDO19462.1 - 0.0013 18.4 0.1 0.002 17.8 0.1 1.2 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.14 EDO19462.1 - 0.008 15.6 0.1 0.012 15.0 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 EDO19462.1 - 0.082 12.5 0.2 0.16 11.6 0.1 1.6 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 EDO19462.1 - 0.14 12.1 0.1 0.28 11.1 0.1 1.4 1 1 0 1 1 1 0 Phosphotransferase enzyme family AcetylCoA_hydro PF02550.15 EDO19463.1 - 3.1e-66 223.2 0.0 6.1e-66 222.2 0.0 1.5 1 0 0 1 1 1 1 Acetyl-CoA hydrolase/transferase N-terminal domain AcetylCoA_hyd_C PF13336.6 EDO19463.1 - 3e-42 144.1 0.0 4.4e-42 143.6 0.0 1.2 1 0 0 1 1 1 1 Acetyl-CoA hydrolase/transferase C-terminal domain CitF PF04223.12 EDO19463.1 - 0.0038 16.2 0.3 0.0072 15.3 0.2 1.4 1 1 0 1 1 1 1 Citrate lyase, alpha subunit (CitF) CoA_trans PF01144.23 EDO19463.1 - 0.014 14.8 0.0 0.15 11.4 0.0 2.2 2 0 0 2 2 2 0 Coenzyme A transferase DNA_topoisoIV PF00521.20 EDO19464.1 - 5.1e-120 401.2 0.2 5.1e-120 401.2 0.2 2.4 3 1 0 3 3 3 1 DNA gyrase/topoisomerase IV, subunit A TOPRIM_C PF16898.5 EDO19464.1 - 1.3e-48 164.5 0.8 1.3e-48 164.5 0.8 3.5 4 0 0 4 4 4 1 C-terminal associated domain of TOPRIM DNA_gyraseB PF00204.25 EDO19464.1 - 1.5e-27 96.2 6.1 3.2e-27 95.1 6.1 1.6 1 0 0 1 1 1 1 DNA gyrase B HATPase_c PF02518.26 EDO19464.1 - 5.7e-13 49.4 0.0 2.4e-12 47.3 0.0 2.1 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Toprim PF01751.22 EDO19464.1 - 6.8e-08 32.7 0.0 3.5e-07 30.4 0.0 2.3 1 0 0 1 1 1 1 Toprim domain OST3_OST6 PF04756.13 EDO19465.1 - 4.3e-80 269.2 3.5 5.8e-80 268.8 3.5 1.1 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family YbjM PF11045.8 EDO19465.1 - 0.028 14.6 0.1 0.028 14.6 0.1 2.6 2 1 1 3 3 3 0 Putative inner membrane protein of Enterobacteriaceae XPG_N PF00752.17 EDO19466.1 - 2.1e-21 76.3 0.0 3.8e-21 75.5 0.0 1.4 1 0 0 1 1 1 1 XPG N-terminal domain MKT1_N PF12247.8 EDO19466.1 - 1.4e-20 73.4 0.1 8.3e-20 70.9 0.0 2.4 2 0 0 2 2 2 1 Temperature dependent protein affecting M2 dsRNA replication XPG_I PF00867.18 EDO19466.1 - 0.016 15.5 0.6 0.04 14.3 0.0 2.0 2 1 0 2 2 2 0 XPG I-region MKT1_C PF12246.8 EDO19467.1 - 9.6e-53 178.9 5.7 1.2e-52 178.6 5.7 1.1 1 0 0 1 1 1 1 Temperature dependent protein affecting M2 dsRNA replication EF-hand_4 PF12763.7 EDO19468.1 - 3.8e-51 171.4 8.6 3.8e-49 165.0 2.9 2.9 3 1 0 3 3 3 2 Cytoskeletal-regulatory complex EF hand End3 PF12761.7 EDO19468.1 - 1.5e-36 126.4 9.5 8.6e-36 124.0 9.5 2.0 1 1 0 1 1 1 1 Actin cytoskeleton-regulatory complex protein END3 EF-hand_1 PF00036.32 EDO19468.1 - 0.0082 15.6 2.0 0.022 14.3 2.0 1.8 1 0 0 1 1 1 1 EF hand SKA1 PF07160.12 EDO19468.1 - 0.099 12.5 8.0 0.78 9.5 1.8 2.8 2 1 1 3 3 3 0 Spindle and kinetochore-associated protein 1 DUF4140 PF13600.6 EDO19468.1 - 0.43 11.1 4.8 1 9.9 0.5 2.6 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) Spc24 PF08286.11 EDO19468.1 - 2.1 8.6 8.7 1.7 8.9 1.0 2.9 3 0 0 3 3 3 0 Spc24 subunit of Ndc80 Syntaxin-6_N PF09177.11 EDO19468.1 - 5 7.7 8.8 2.2 8.9 0.8 2.8 1 1 1 2 2 2 0 Syntaxin 6, N-terminal Ribosomal_S13 PF00416.22 EDO19469.1 - 3.6e-17 63.0 0.0 3.5e-15 56.5 0.0 2.0 1 1 0 1 1 1 1 Ribosomal protein S13/S18 Tropomyosin_1 PF12718.7 EDO19470.1 - 2.5e-52 176.8 42.2 2.9e-52 176.6 42.2 1.0 1 0 0 1 1 1 1 Tropomyosin like CENP-F_leu_zip PF10473.9 EDO19470.1 - 1.7e-07 31.3 41.4 9.5e-07 28.9 8.2 2.4 1 1 1 2 2 2 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Tropomyosin PF00261.20 EDO19470.1 - 5.3e-07 29.3 37.1 0.0014 18.1 15.2 2.0 1 1 1 2 2 2 2 Tropomyosin Laminin_II PF06009.12 EDO19470.1 - 6.2e-05 23.0 25.0 0.00094 19.2 11.5 2.5 1 1 1 2 2 2 2 Laminin Domain II KLRAQ PF10205.9 EDO19470.1 - 0.00011 22.4 30.7 0.0022 18.2 13.9 2.1 1 1 1 2 2 2 2 Predicted coiled-coil domain-containing protein GAS PF13851.6 EDO19470.1 - 0.00019 20.9 38.8 0.31 10.4 37.7 2.5 1 1 0 1 1 1 1 Growth-arrest specific micro-tubule binding TMF_DNA_bd PF12329.8 EDO19470.1 - 0.0016 18.4 45.5 0.0033 17.4 18.8 3.5 1 1 2 3 3 3 1 TATA element modulatory factor 1 DNA binding CLZ PF16526.5 EDO19470.1 - 0.0016 18.7 31.6 0.15 12.4 1.6 4.0 1 1 3 4 4 4 3 C-terminal leucine zipper domain of cyclic nucleotide-gated channels ADIP PF11559.8 EDO19470.1 - 0.0027 17.8 34.0 0.19 11.8 13.1 2.3 1 1 1 2 2 2 2 Afadin- and alpha -actinin-Binding DHR10 PF18595.1 EDO19470.1 - 0.0031 17.6 36.1 0.016 15.3 15.5 2.4 1 1 1 2 2 2 1 Designed helical repeat protein 10 domain Spc7 PF08317.11 EDO19470.1 - 0.0031 16.4 37.7 0.0058 15.5 14.6 2.1 1 1 1 2 2 2 1 Spc7 kinetochore protein Fez1 PF06818.15 EDO19470.1 - 0.0068 16.9 29.5 0.0085 16.6 29.5 1.2 1 0 0 1 1 1 1 Fez1 IFT57 PF10498.9 EDO19470.1 - 0.0069 15.4 12.7 0.0069 15.4 12.7 2.3 1 1 1 2 2 2 1 Intra-flagellar transport protein 57 FlaC_arch PF05377.11 EDO19470.1 - 0.0092 16.4 30.6 0.11 12.9 0.1 5.0 1 1 3 4 4 3 3 Flagella accessory protein C (FlaC) Taxilin PF09728.9 EDO19470.1 - 0.012 14.8 37.6 0.019 14.1 14.3 2.9 1 1 0 2 2 2 0 Myosin-like coiled-coil protein MbeD_MobD PF04899.12 EDO19470.1 - 0.016 15.3 11.2 0.026 14.6 2.0 2.8 2 1 1 3 3 3 0 MbeD/MobD like ATG16 PF08614.11 EDO19470.1 - 0.018 15.3 36.9 0.29 11.4 16.5 2.0 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) DUF724 PF05266.14 EDO19470.1 - 0.033 14.0 28.6 0.49 10.2 11.5 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF724) DUF3450 PF11932.8 EDO19470.1 - 0.035 13.4 32.0 0.083 12.2 14.4 2.5 1 1 2 3 3 3 0 Protein of unknown function (DUF3450) ERM PF00769.19 EDO19470.1 - 0.035 13.9 37.2 0.37 10.6 34.9 2.0 1 1 0 1 1 1 0 Ezrin/radixin/moesin family ZapB PF06005.12 EDO19470.1 - 0.041 14.3 46.3 7.6 7.1 3.5 3.8 1 1 0 2 2 1 0 Cell division protein ZapB DUF4200 PF13863.6 EDO19470.1 - 0.044 14.2 39.6 0.061 13.7 17.9 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) DUF1664 PF07889.12 EDO19470.1 - 0.045 13.8 19.2 0.78 9.8 5.9 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) CENP-K PF11802.8 EDO19470.1 - 0.052 13.1 32.9 0.028 14.0 11.5 2.0 1 1 1 2 2 2 0 Centromere-associated protein K DUF2353 PF09789.9 EDO19470.1 - 0.054 12.8 28.8 0.072 12.4 28.8 1.2 1 0 0 1 1 1 0 Uncharacterized coiled-coil protein (DUF2353) bZIP_2 PF07716.15 EDO19470.1 - 0.055 13.6 2.9 0.055 13.6 2.9 4.8 2 2 3 5 5 5 0 Basic region leucine zipper BLOC1_2 PF10046.9 EDO19470.1 - 0.068 13.5 30.4 0.45 10.8 10.9 3.5 1 1 2 3 3 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 KELK PF15796.5 EDO19470.1 - 0.071 13.6 2.7 0.071 13.6 2.7 4.0 1 1 3 4 4 4 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase Atg14 PF10186.9 EDO19470.1 - 0.087 11.9 30.0 0.047 12.8 10.5 2.0 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 Cep57_MT_bd PF06657.13 EDO19470.1 - 0.093 13.2 1.4 0.093 13.2 1.4 3.9 1 1 3 4 4 4 0 Centrosome microtubule-binding domain of Cep57 APG6_N PF17675.1 EDO19470.1 - 0.11 13.1 46.1 0.58 10.7 19.9 2.1 1 1 1 2 2 2 0 Apg6 coiled-coil region Mod_r PF07200.13 EDO19470.1 - 0.13 12.3 37.6 1.2 9.2 14.8 2.5 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein Ax_dynein_light PF10211.9 EDO19470.1 - 0.14 12.1 38.1 0.44 10.5 4.6 3.3 1 1 3 4 4 4 0 Axonemal dynein light chain TPR_MLP1_2 PF07926.12 EDO19470.1 - 0.16 12.1 41.6 1.4 8.9 16.2 3.2 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein DUF4472 PF14739.6 EDO19470.1 - 0.16 12.7 29.3 0.69 10.7 9.3 2.5 1 1 2 3 3 3 0 Domain of unknown function (DUF4472) Sec34 PF04136.15 EDO19470.1 - 0.17 11.8 25.7 1.2 9.1 13.1 2.2 1 1 1 2 2 2 0 Sec34-like family HOOK PF05622.12 EDO19470.1 - 0.19 9.9 34.9 0.24 9.5 34.9 1.2 1 0 0 1 1 1 0 HOOK protein EzrA PF06160.12 EDO19470.1 - 0.19 9.9 34.8 0.38 8.9 13.7 2.1 1 1 1 2 2 2 0 Septation ring formation regulator, EzrA Fzo_mitofusin PF04799.13 EDO19470.1 - 0.23 11.0 21.3 0.15 11.6 5.9 2.6 1 1 1 2 2 2 0 fzo-like conserved region AAA_13 PF13166.6 EDO19470.1 - 0.31 9.6 31.2 0.014 14.1 11.6 2.0 1 1 1 2 2 2 0 AAA domain bZIP_1 PF00170.21 EDO19470.1 - 0.31 11.2 40.3 0.68 10.1 1.4 4.5 2 1 2 4 4 4 0 bZIP transcription factor Jnk-SapK_ap_N PF09744.9 EDO19470.1 - 0.35 11.1 39.9 0.21 11.8 24.5 2.2 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 FPP PF05911.11 EDO19470.1 - 0.36 8.9 37.5 0.16 10.2 17.9 2.0 1 1 1 2 2 2 0 Filament-like plant protein, long coiled-coil KASH_CCD PF14662.6 EDO19470.1 - 0.45 10.3 41.3 0.16 11.8 18.5 2.2 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 or KASH DUF5082 PF16888.5 EDO19470.1 - 0.45 10.8 27.4 0.81 10.0 5.8 2.7 1 1 2 3 3 3 0 Domain of unknown function (DUF5082) OmpH PF03938.14 EDO19470.1 - 0.46 10.8 35.8 0.3 11.4 14.4 2.3 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) CC2-LZ PF16516.5 EDO19470.1 - 0.5 10.8 28.7 0.46 10.9 18.8 2.4 1 1 1 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator Rho_Binding PF08912.11 EDO19470.1 - 0.6 11.0 44.2 0.87 10.5 11.5 3.9 1 1 2 3 3 3 0 Rho Binding DivIC PF04977.15 EDO19470.1 - 0.62 9.9 38.3 0.042 13.6 10.5 4.2 1 1 3 4 4 4 0 Septum formation initiator Lebercilin PF15619.6 EDO19470.1 - 0.62 9.7 36.4 12 5.5 36.2 2.1 1 1 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease DUF3584 PF12128.8 EDO19470.1 - 0.68 7.4 31.6 0.76 7.2 31.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) LRRFIP PF09738.9 EDO19470.1 - 0.78 9.2 31.9 1 8.8 31.9 1.1 1 0 0 1 1 1 0 LRRFIP family FTO_CTD PF12934.7 EDO19470.1 - 0.78 9.5 12.9 0.12 12.2 6.6 2.1 1 1 1 2 2 2 0 FTO C-terminal domain NPV_P10 PF05531.12 EDO19470.1 - 0.93 10.0 16.8 4.9 7.7 0.3 3.7 1 1 2 3 3 3 0 Nucleopolyhedrovirus P10 protein Uso1_p115_C PF04871.13 EDO19470.1 - 0.96 9.8 40.9 1.4 9.3 17.0 2.3 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region Phage_tail_NK PF16532.5 EDO19470.1 - 1.1 8.9 3.0 6.7 6.3 0.2 2.1 2 0 0 2 2 2 0 Sf6-type phage tail needle knob or tip of some Caudovirales DUF4407 PF14362.6 EDO19470.1 - 1.1 8.5 23.5 2.2 7.5 23.5 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) DUF4201 PF13870.6 EDO19470.1 - 1.2 8.9 35.1 10 5.8 35.1 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4201) Sec2p PF06428.11 EDO19470.1 - 1.6 8.7 37.4 0.26 11.3 18.6 3.6 1 1 2 3 3 3 0 GDP/GTP exchange factor Sec2p HAUS6_N PF14661.6 EDO19470.1 - 1.8 8.1 25.5 0.3 10.6 8.5 2.0 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus Phage_GP20 PF06810.11 EDO19470.1 - 1.9 8.3 34.4 6.7 6.5 24.3 2.7 1 1 1 2 2 2 0 Phage minor structural protein GP20 Spc24 PF08286.11 EDO19470.1 - 2.1 8.6 37.7 4.6 7.5 5.8 4.0 1 1 3 4 4 4 0 Spc24 subunit of Ndc80 Fungal_TACC PF12709.7 EDO19470.1 - 2.8 8.4 35.8 1.3 9.5 3.4 4.2 1 1 3 4 4 4 0 Fungal Transforming acidic coiled-coil (TACC) proteins T3SSipB PF16535.5 EDO19470.1 - 3.3 8.2 19.3 18 5.8 11.6 2.7 1 1 0 2 2 2 0 Type III cell invasion protein SipB Lectin_N PF03954.14 EDO19470.1 - 4.3 7.1 19.6 3 7.6 7.5 3.0 1 1 2 3 3 3 0 Hepatic lectin, N-terminal domain PI3K_P85_iSH2 PF16454.5 EDO19470.1 - 4.5 6.8 32.7 5.4 6.6 27.4 2.5 1 1 1 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain Acetyltransf_11 PF13720.6 EDO19470.1 - 4.8 7.7 7.3 3.8 8.1 1.1 2.6 1 1 1 2 2 2 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 Cnn_1N PF07989.11 EDO19470.1 - 4.9 7.4 37.4 20 5.4 5.5 3.4 1 1 2 3 3 3 0 Centrosomin N-terminal motif 1 DUF3552 PF12072.8 EDO19470.1 - 5.5 6.4 38.4 3.8 6.9 16.2 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF3552) LPP PF04728.13 EDO19470.1 - 5.6 7.4 14.4 3.4 8.1 3.3 4.0 1 1 2 3 3 3 0 Lipoprotein leucine-zipper DUF4795 PF16043.5 EDO19470.1 - 6.1 6.4 32.9 19 4.8 32.9 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4795) LprI PF07007.12 EDO19470.1 - 6.3 7.5 14.9 0.42 11.3 4.3 2.5 1 1 0 2 2 2 0 Lysozyme inhibitor LprI HemX PF04375.14 EDO19470.1 - 6.9 5.8 26.4 6.4 6.0 12.5 2.2 1 1 1 2 2 2 0 HemX, putative uroporphyrinogen-III C-methyltransferase RmuC PF02646.16 EDO19470.1 - 7 5.7 25.0 2.5 7.1 9.7 3.1 1 1 2 3 3 3 0 RmuC family Prefoldin_2 PF01920.20 EDO19470.1 - 7.2 6.6 42.6 2.2 8.3 6.9 4.2 1 1 2 3 3 3 0 Prefoldin subunit DUF4446 PF14584.6 EDO19470.1 - 8 6.4 23.3 1.4 8.9 6.9 3.0 1 1 2 3 3 3 0 Protein of unknown function (DUF4446) Exonuc_VII_S PF02609.16 EDO19470.1 - 8.2 6.6 23.1 2.7 8.1 0.3 4.8 4 1 0 4 4 4 0 Exonuclease VII small subunit FliD_C PF07195.12 EDO19470.1 - 8.3 5.7 25.3 1.7 8.0 0.7 3.1 1 1 2 3 3 3 0 Flagellar hook-associated protein 2 C-terminus TMPIT PF07851.13 EDO19470.1 - 9.6 5.3 28.2 4.4 6.4 10.5 2.0 1 1 1 2 2 2 0 TMPIT-like protein TMF_TATA_bd PF12325.8 EDO19470.1 - 9.7 6.5 35.8 5.2 7.3 1.6 3.0 1 1 1 2 2 1 0 TATA element modulatory factor 1 TATA binding CEP209_CC5 PF16574.5 EDO19470.1 - 9.8 6.4 32.9 0.63 10.2 12.0 2.6 1 1 1 2 2 2 0 Coiled-coil region of centrosome protein CE290 Peptidase_M1 PF01433.20 EDO19471.1 - 1.2e-55 188.4 2.9 1.2e-55 188.4 2.9 2.4 2 0 0 2 2 2 1 Peptidase family M1 domain Peptidase_M1_N PF17900.1 EDO19471.1 - 5.7e-34 117.9 4.4 3.1e-33 115.6 1.5 2.4 2 0 0 2 2 2 1 Peptidase M1 N-terminal domain ERAP1_C PF11838.8 EDO19471.1 - 1.1e-20 74.4 0.0 1.9e-20 73.7 0.0 1.2 1 0 0 1 1 1 1 ERAP1-like C-terminal domain Aminopep PF10023.9 EDO19471.1 - 0.042 13.2 0.3 0.1 11.9 0.1 1.7 2 0 0 2 2 2 0 Putative aminopeptidase KH_8 PF17903.1 EDO19471.1 - 0.068 13.3 0.4 0.28 11.3 0.4 2.0 1 0 0 1 1 1 0 Krr1 KH1 domain DnaJ_C PF01556.18 EDO19472.1 - 9.7e-27 93.9 0.1 1.4e-26 93.3 0.1 1.3 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 EDO19472.1 - 3.8e-24 84.6 3.6 7.5e-24 83.6 3.6 1.5 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 EDO19472.1 - 3.2e-12 46.6 14.5 5.7e-12 45.8 14.5 1.4 1 0 0 1 1 1 1 DnaJ central domain UPF0223 PF05256.12 EDO19472.1 - 0.78 10.1 4.7 0.59 10.5 2.6 1.8 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0223) Anti-TRAP PF15777.5 EDO19472.1 - 0.92 9.5 8.4 0.23 11.4 0.9 2.6 1 1 2 3 3 3 0 Tryptophan RNA-binding attenuator protein inhibitory protein SET_assoc PF11767.8 EDO19473.1 - 0.096 12.3 0.1 0.76 9.5 0.0 2.3 3 0 0 3 3 3 0 Histone lysine methyltransferase SET associated Cytokin_check_N PF10407.9 EDO19474.1 - 6.5e-32 109.3 4.4 2e-31 107.7 4.4 1.9 1 0 0 1 1 1 1 Cdc14 phosphatase binding protein N-terminus Alpha-amylase PF00128.24 EDO19474.1 - 0.46 10.0 0.0 0.46 10.0 0.0 2.8 3 0 0 3 3 3 0 Alpha amylase, catalytic domain SMC_N PF02463.19 EDO19475.1 - 1.4e-51 175.0 59.6 3e-50 170.7 59.6 3.6 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 EDO19475.1 - 2.2e-29 102.1 0.0 8.4e-29 100.3 0.0 2.1 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_23 PF13476.6 EDO19475.1 - 4.3e-19 69.8 6.6 4.3e-19 69.8 6.6 7.1 3 2 2 6 6 6 1 AAA domain AAA_21 PF13304.6 EDO19475.1 - 7.2e-14 52.3 16.8 1.2e-07 31.8 7.6 4.0 3 2 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 EDO19475.1 - 1.1e-05 25.3 104.6 1.2e-05 25.2 42.7 4.8 2 2 2 4 4 4 2 AAA ATPase domain DUF4795 PF16043.5 EDO19475.1 - 0.00065 19.4 10.8 0.00065 19.4 10.8 6.7 2 2 4 6 6 6 1 Domain of unknown function (DUF4795) BLOC1_2 PF10046.9 EDO19475.1 - 0.005 17.1 3.9 0.005 17.1 3.9 10.2 5 3 6 11 11 11 3 Biogenesis of lysosome-related organelles complex-1 subunit 2 AAA_29 PF13555.6 EDO19475.1 - 0.0088 15.8 0.0 0.019 14.7 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain CENP-F_leu_zip PF10473.9 EDO19475.1 - 2.1 8.4 128.6 0.92 9.5 18.6 7.8 3 3 3 7 7 7 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Mem_trans PF03547.18 EDO19476.1 - 1.3e-66 224.6 11.9 1.5e-65 221.1 11.9 1.9 1 1 0 1 1 1 1 Membrane transport protein DUF2542 PF10808.8 EDO19476.1 - 3.1 8.3 7.7 1.2 9.6 1.0 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF2542) FixS PF03597.15 EDO19476.1 - 3.5 7.4 6.8 13 5.6 0.6 3.4 2 0 0 2 2 2 0 Cytochrome oxidase maturation protein cbb3-type Methyltransf_11 PF08241.12 EDO19477.1 - 2.2e-13 50.7 0.0 1.2e-12 48.2 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDO19477.1 - 1.7e-12 47.9 0.0 4.3e-11 43.4 0.0 2.5 2 0 0 2 2 2 1 Methyltransferase domain WBS_methylT PF12589.8 EDO19477.1 - 1.8e-12 47.8 5.6 3.5e-12 46.9 5.6 1.5 1 0 0 1 1 1 1 Methyltransferase involved in Williams-Beuren syndrome Methyltransf_12 PF08242.12 EDO19477.1 - 1e-06 29.4 0.0 5.7e-06 27.0 0.0 2.2 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDO19477.1 - 9.8e-06 25.4 0.0 4.2e-05 23.4 0.0 1.9 1 1 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 EDO19477.1 - 9e-05 22.4 0.0 0.00013 21.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 EDO19477.1 - 0.00048 19.5 0.0 0.013 14.8 0.0 2.5 2 1 0 2 2 2 1 Mycolic acid cyclopropane synthetase AdoMet_MTase PF07757.13 EDO19477.1 - 0.0043 17.4 0.0 0.0097 16.2 0.0 1.6 1 0 0 1 1 1 1 Predicted AdoMet-dependent methyltransferase PCMT PF01135.19 EDO19477.1 - 0.0051 16.6 0.0 0.013 15.3 0.0 1.7 2 0 0 2 2 2 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MetW PF07021.12 EDO19477.1 - 0.0062 16.1 0.0 0.011 15.4 0.0 1.3 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW PrmA PF06325.13 EDO19477.1 - 0.011 15.1 0.1 0.024 14.0 0.0 1.6 2 0 0 2 2 2 0 Ribosomal protein L11 methyltransferase (PrmA) N6_N4_Mtase PF01555.18 EDO19477.1 - 0.063 13.0 0.3 0.54 9.9 0.0 2.1 2 1 0 2 2 2 0 DNA methylase Methyltransf_32 PF13679.6 EDO19477.1 - 0.093 12.7 0.0 0.39 10.7 0.0 1.9 2 0 0 2 2 2 0 Methyltransferase domain GidB PF02527.15 EDO19477.1 - 0.14 11.5 0.0 0.28 10.5 0.0 1.4 1 0 0 1 1 1 0 rRNA small subunit methyltransferase G Peptidase_S8 PF00082.22 EDO19478.1 - 3.7e-29 101.9 0.7 1.4e-28 100.1 0.7 1.7 1 1 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 EDO19478.1 - 0.016 15.9 0.0 0.029 15.0 0.0 1.4 1 0 0 1 1 1 0 Peptidase inhibitor I9 Imm48 PF15574.6 EDO19478.1 - 0.094 12.5 0.1 12 5.7 0.0 2.6 2 0 0 2 2 2 0 Immunity protein 48 Tim17 PF02466.19 EDO19479.1 - 1.9e-24 86.2 3.3 2.6e-24 85.7 3.3 1.2 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family ACC_central PF08326.12 EDO19481.1 - 3.2e-260 865.4 0.0 4.2e-260 865.0 0.0 1.2 1 0 0 1 1 1 1 Acetyl-CoA carboxylase, central region Carboxyl_trans PF01039.22 EDO19481.1 - 3.5e-189 629.5 0.0 4.6e-189 629.1 0.0 1.2 1 0 0 1 1 1 1 Carboxyl transferase domain CPSase_L_D2 PF02786.17 EDO19481.1 - 1.7e-49 168.2 0.0 3.5e-49 167.2 0.0 1.5 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.22 EDO19481.1 - 7.6e-30 103.7 0.1 2.1e-29 102.3 0.1 1.8 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 EDO19481.1 - 8e-21 74.2 0.0 4.3e-20 71.8 0.0 2.4 2 0 0 2 2 2 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.22 EDO19481.1 - 2.3e-18 65.8 0.2 7.2e-18 64.2 0.2 2.0 1 0 0 1 1 1 1 Biotin-requiring enzyme ABC_tran_CTD PF16326.5 EDO19481.1 - 0.0035 17.6 0.9 0.012 15.9 0.9 1.9 1 0 0 1 1 1 1 ABC transporter C-terminal domain ATP-grasp_3 PF02655.14 EDO19481.1 - 0.0055 16.8 0.0 0.025 14.6 0.0 2.2 1 0 0 1 1 1 1 ATP-grasp domain Dala_Dala_lig_C PF07478.13 EDO19481.1 - 0.006 16.1 0.1 0.022 14.3 0.0 2.0 2 0 0 2 2 2 1 D-ala D-ala ligase C-terminus ATPgrasp_Ter PF15632.6 EDO19481.1 - 0.072 12.8 0.0 0.17 11.6 0.0 1.6 1 0 0 1 1 1 0 ATP-grasp in the biosynthetic pathway with Ter operon DUF4667 PF15700.5 EDO19482.1 - 2.6e-31 109.6 18.3 5e-25 89.0 17.0 2.8 1 1 1 2 2 2 2 Domain of unknown function (DUF4667) DUF2572 PF10833.8 EDO19482.1 - 0.037 13.8 0.5 0.044 13.5 0.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2572) ANAPC9 PF12856.7 EDO19482.1 - 4.3 7.5 10.8 0.42 10.8 5.1 1.9 1 1 0 2 2 2 0 Anaphase-promoting complex subunit 9 SPX PF03105.19 EDO19483.1 - 6.1e-37 128.4 11.8 7.9e-21 75.4 0.3 2.6 2 1 1 3 3 3 2 SPX domain Na_sulph_symp PF00939.19 EDO19483.1 - 1e-26 94.1 42.4 1.5e-26 93.5 42.4 1.1 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.16 EDO19483.1 - 8.4e-26 90.9 55.4 2.7e-22 79.3 31.0 2.2 1 1 1 2 2 2 2 Citrate transporter PFK PF00365.20 EDO19484.1 - 2e-179 595.0 2.1 8.3e-99 330.5 0.5 2.2 2 0 0 2 2 2 2 Phosphofructokinase UVR PF02151.19 EDO19484.1 - 0.072 12.9 0.5 0.16 11.8 0.5 1.6 1 0 0 1 1 1 0 UvrB/uvrC motif DAGK_cat PF00781.24 EDO19484.1 - 0.16 11.6 0.2 0.84 9.3 0.1 2.2 2 0 0 2 2 2 0 Diacylglycerol kinase catalytic domain Inp1 PF12634.7 EDO19485.1 - 4.1e-36 124.0 0.4 4.1e-36 124.0 0.4 2.5 2 1 0 2 2 2 1 Inheritance of peroxisomes protein 1 Med9 PF07544.13 EDO19486.1 - 3e-26 91.3 0.7 3e-26 91.3 0.7 1.8 2 0 0 2 2 2 1 RNA polymerase II transcription mediator complex subunit 9 Cortex-I_coil PF09304.10 EDO19486.1 - 0.41 10.9 5.3 0.1 12.8 1.8 1.7 2 0 0 2 2 2 0 Cortexillin I, coiled coil Whi5 PF08528.11 EDO19487.1 - 3.1e-10 39.4 0.1 6e-10 38.5 0.1 1.5 1 0 0 1 1 1 1 Whi5 like XPA_C PF05181.12 EDO19488.1 - 1.3e-21 76.3 0.2 3e-21 75.1 0.2 1.6 1 0 0 1 1 1 1 XPA protein C-terminus XPA_N PF01286.18 EDO19488.1 - 0.0042 17.1 1.0 0.0042 17.1 1.0 2.4 3 0 0 3 3 3 1 XPA protein N-terminal GA-like PF17573.2 EDO19488.1 - 0.095 12.6 0.2 0.2 11.6 0.2 1.5 1 0 0 1 1 1 0 GA-like domain VHS PF00790.19 EDO19489.1 - 9e-35 119.6 0.4 9e-35 119.6 0.4 2.0 2 0 0 2 2 2 1 VHS domain FYVE PF01363.21 EDO19489.1 - 2.5e-19 69.2 2.9 5.9e-19 68.0 2.9 1.6 1 0 0 1 1 1 1 FYVE zinc finger UIM PF02809.20 EDO19489.1 - 1.1e-06 28.1 6.4 0.0036 17.1 2.7 3.0 2 0 0 2 2 2 2 Ubiquitin interaction motif GAT PF03127.14 EDO19489.1 - 0.0038 17.5 1.8 0.0038 17.5 1.8 2.7 3 0 0 3 3 3 1 GAT domain FYVE_2 PF02318.16 EDO19489.1 - 0.01 16.1 1.2 0.01 16.1 1.2 2.4 2 0 0 2 2 2 0 FYVE-type zinc finger OAD_gamma PF04277.13 EDO19489.1 - 1.8 9.2 3.9 13 6.5 3.9 2.4 1 1 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain zf-AN1 PF01428.16 EDO19489.1 - 2.1 8.6 13.6 0.08 13.1 7.5 1.7 2 0 0 2 2 2 0 AN1-like Zinc finger DUF778 PF05608.12 EDO19489.1 - 2.7 8.3 7.5 14 6.0 0.1 3.3 3 1 0 3 3 3 0 Protein of unknown function (DUF778) Rot1 PF10681.9 EDO19490.1 - 1.7e-94 315.2 0.0 1.9e-94 315.0 0.0 1.0 1 0 0 1 1 1 1 Chaperone for protein-folding within the ER, fungal Cyclin_N PF00134.23 EDO19491.1 - 3.5e-39 133.5 0.0 7.2e-39 132.4 0.0 1.6 1 0 0 1 1 1 1 Cyclin, N-terminal domain CHASE6_C PF17150.4 EDO19491.1 - 0.044 14.5 3.0 4.8 7.9 0.3 3.0 3 0 0 3 3 3 0 C-terminal domain of two-partite extracellular sensor domain Phage_prot_Gp6 PF05133.14 EDO19492.1 - 0.0065 15.6 0.3 0.0088 15.2 0.3 1.1 1 0 0 1 1 1 1 Phage portal protein, SPP1 Gp6-like BBP1_C PF15272.6 EDO19493.1 - 7.6e-66 221.6 35.6 1.3e-65 220.8 35.6 1.4 1 0 0 1 1 1 1 Spindle pole body component BBP1, C-terminal BBP1_N PF15271.6 EDO19493.1 - 3.7e-54 183.7 1.1 3.7e-54 183.7 1.1 2.7 2 1 0 2 2 2 1 Spindle pole body component BBP1, Mps2-binding protein HisKA_2 PF07568.12 EDO19493.1 - 0.019 15.1 0.7 0.019 15.1 0.7 2.0 2 0 0 2 2 2 0 Histidine kinase PKcGMP_CC PF16808.5 EDO19493.1 - 0.39 10.6 12.8 1.6 8.6 0.2 4.0 5 0 0 5 5 5 0 Coiled-coil N-terminus of cGMP-dependent protein kinase DUF1465 PF07323.12 EDO19493.1 - 0.4 10.5 6.0 0.39 10.5 2.9 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1465) HSBP1 PF06825.12 EDO19493.1 - 1.2 9.1 7.0 3.4 7.6 0.4 3.1 3 0 0 3 3 3 0 Heat shock factor binding protein 1 DUF4407 PF14362.6 EDO19493.1 - 1.3 8.3 8.1 2 7.7 8.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Ead_Ea22 PF13935.6 EDO19493.1 - 1.5 9.5 8.8 7.7 7.2 8.8 2.1 1 1 0 1 1 1 0 Ead/Ea22-like protein SAGA-Tad1 PF12767.7 EDO19494.1 - 6e-75 252.0 0.0 1e-74 251.3 0.0 1.4 1 0 0 1 1 1 1 Transcriptional regulator of RNA polII, SAGA, subunit TAF4 PF05236.14 EDO19494.1 - 0.002 18.0 0.0 0.004 17.0 0.0 1.5 1 0 0 1 1 1 1 Transcription initiation factor TFIID component TAF4 family TFIID_30kDa PF03540.13 EDO19494.1 - 0.065 13.2 0.0 0.15 12.0 0.0 1.6 1 0 0 1 1 1 0 Transcription initiation factor TFIID 23-30kDa subunit TFIID_20kDa PF03847.13 EDO19494.1 - 0.11 13.0 0.1 0.23 12.0 0.1 1.5 1 0 0 1 1 1 0 Transcription initiation factor TFIID subunit A Microtub_bd PF16796.5 EDO19495.1 - 1.8e-29 102.6 0.2 1.8e-29 102.6 0.2 3.9 2 1 3 5 5 5 1 Microtubule binding Fer2 PF00111.27 EDO19496.1 - 9.1e-14 51.2 0.4 1.3e-13 50.7 0.4 1.2 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain V-SNARE_C PF12352.8 EDO19497.1 - 3.5e-20 72.0 3.7 3.5e-20 72.0 3.7 1.9 2 0 0 2 2 1 1 Snare region anchored in the vesicle membrane C-terminus V-SNARE PF05008.15 EDO19497.1 - 1.3e-18 67.2 3.5 1.3e-18 67.2 3.5 2.4 3 0 0 3 3 3 1 Vesicle transport v-SNARE protein N-terminus Sec20 PF03908.13 EDO19497.1 - 0.00026 20.9 0.7 0.00026 20.9 0.7 2.1 2 0 0 2 2 2 1 Sec20 Myotub-related PF06602.14 EDO19497.1 - 0.024 13.6 0.6 0.028 13.4 0.6 1.1 1 0 0 1 1 1 0 Myotubularin-like phosphatase domain LMBR1 PF04791.16 EDO19497.1 - 0.032 13.1 1.0 0.039 12.9 1.0 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein Fusion_gly PF00523.18 EDO19497.1 - 0.056 11.7 0.4 0.18 10.0 0.1 1.9 2 0 0 2 2 2 0 Fusion glycoprotein F0 DUF948 PF06103.11 EDO19497.1 - 0.17 12.2 0.2 0.17 12.2 0.2 2.8 3 1 0 3 3 2 0 Bacterial protein of unknown function (DUF948) Use1 PF09753.9 EDO19497.1 - 0.24 11.1 8.6 2.7 7.7 8.6 2.2 1 1 0 1 1 1 0 Membrane fusion protein Use1 Rogdi_lz PF10259.9 EDO19497.1 - 0.45 9.9 4.3 6 6.2 0.4 2.1 2 0 0 2 2 2 0 Rogdi leucine zipper containing protein YqjK PF13997.6 EDO19497.1 - 0.64 10.3 0.0 0.64 10.3 0.0 3.3 3 0 0 3 3 3 0 YqjK-like protein Nsp1_C PF05064.13 EDO19497.1 - 1.5 8.6 9.9 0.043 13.6 2.2 2.4 3 1 0 3 3 3 0 Nsp1-like C-terminal region Glyco_hydro_63 PF03200.16 EDO19498.1 - 2.5e-05 23.2 12.8 0.00095 18.0 0.5 5.0 5 1 0 5 5 5 2 Glycosyl hydrolase family 63 C-terminal domain DUF2207 PF09972.9 EDO19498.1 - 0.0063 15.3 0.1 0.0063 15.3 0.1 1.6 2 0 0 2 2 2 1 Predicted membrane protein (DUF2207) Ribosomal_L36e PF01158.18 EDO19500.1 - 7e-36 122.4 3.8 7.8e-36 122.2 3.8 1.0 1 0 0 1 1 1 1 Ribosomal protein L36e HHH_2 PF12826.7 EDO19500.1 - 0.085 13.0 0.1 0.16 12.1 0.1 1.4 1 0 0 1 1 1 0 Helix-hairpin-helix motif RabGAP-TBC PF00566.18 EDO19501.1 - 2.9e-48 164.4 0.6 2.9e-48 164.4 0.6 3.4 4 0 0 4 4 4 1 Rab-GTPase-TBC domain Pox_A_type_inc PF04508.12 EDO19501.1 - 0.75 9.7 3.7 37 4.4 0.1 3.8 3 0 0 3 3 3 0 Viral A-type inclusion protein repeat bZIP_2 PF07716.15 EDO19501.1 - 2.8 8.1 13.3 0.82 9.8 1.5 3.3 2 0 0 2 2 2 0 Basic region leucine zipper Helicase_Sgs1 PF11408.8 EDO19502.1 - 8.2e-35 118.7 1.1 2.4e-34 117.2 1.1 1.9 1 0 0 1 1 1 1 Sgs1 RecQ helicase RQC PF09382.10 EDO19502.1 - 2.2e-27 95.1 0.0 4.3e-27 94.2 0.0 1.5 1 0 0 1 1 1 1 RQC domain Helicase_C PF00271.31 EDO19502.1 - 1.3e-20 73.8 6.0 2.2e-17 63.4 0.0 4.0 5 0 0 5 5 5 2 Helicase conserved C-terminal domain DEAD PF00270.29 EDO19502.1 - 2e-20 73.3 0.0 4.8e-20 72.0 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase RecQ_Zn_bind PF16124.5 EDO19502.1 - 8.7e-16 58.4 8.2 3.2e-15 56.6 8.2 2.1 1 0 0 1 1 1 1 RecQ zinc-binding ResIII PF04851.15 EDO19502.1 - 2.1e-06 27.8 1.3 1.2e-05 25.4 0.0 2.9 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit Trypan_PARP PF05887.11 EDO19502.1 - 0.00018 21.5 13.2 0.00018 21.5 13.2 2.7 2 0 0 2 2 2 1 Procyclic acidic repetitive protein (PARP) HRDC PF00570.23 EDO19502.1 - 0.054 13.5 0.0 0.13 12.3 0.0 1.6 1 0 0 1 1 1 0 HRDC domain Rhodanese PF00581.20 EDO19502.1 - 0.081 13.5 0.6 4.3 7.9 0.0 3.2 3 0 0 3 3 3 0 Rhodanese-like domain Neisseria_TspB PF05616.13 EDO19502.1 - 3.1 6.2 26.0 6.3 5.1 26.0 1.4 1 0 0 1 1 1 0 Neisseria meningitidis TspB protein HMG_box PF00505.19 EDO19503.1 - 2.9e-28 98.1 5.9 2.2e-17 63.2 0.6 2.1 2 0 0 2 2 2 2 HMG (high mobility group) box HMG_box_2 PF09011.10 EDO19503.1 - 5.1e-16 59.0 3.2 6.6e-09 36.2 0.1 2.2 2 0 0 2 2 2 2 HMG-box domain MlaC PF05494.12 EDO19503.1 - 0.0093 15.7 0.0 1.1 9.0 0.0 2.2 2 0 0 2 2 2 2 MlaC protein Arg_decarbox_C PF17944.1 EDO19503.1 - 0.032 14.8 0.9 6 7.5 0.0 2.5 2 0 0 2 2 2 0 Arginine decarboxylase C-terminal helical extension Catalase-rel PF06628.12 EDO19503.1 - 0.075 13.3 0.2 13 6.1 0.0 2.3 2 0 0 2 2 2 0 Catalase-related immune-responsive CHDNT PF08073.12 EDO19503.1 - 0.092 12.7 0.0 1.2 9.2 0.0 2.4 2 0 0 2 2 2 0 CHDNT (NUC034) domain zf-C2H2 PF00096.26 EDO19504.1 - 3.9e-06 27.0 13.8 1.7e-05 25.0 3.9 2.9 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EDO19504.1 - 0.00027 21.5 14.2 0.0032 18.2 4.2 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger zf-Di19 PF05605.12 EDO19504.1 - 0.0016 18.7 3.2 0.0057 16.9 3.2 1.9 1 1 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_2 PF12756.7 EDO19504.1 - 0.075 13.4 6.6 1.3 9.4 0.8 2.8 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.8 EDO19504.1 - 0.13 12.6 1.5 0.34 11.3 1.5 1.8 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding zf-C2H2_aberr PF17017.5 EDO19504.1 - 0.96 9.6 6.7 0.16 12.1 1.2 2.4 2 1 0 2 2 2 0 Aberrant zinc-finger zf-H2C2_2 PF13465.6 EDO19504.1 - 1.2 9.7 10.5 1.3 9.6 1.1 3.2 3 0 0 3 3 3 0 Zinc-finger double domain zf-C2H2_6 PF13912.6 EDO19504.1 - 6.6 6.9 6.7 0.28 11.2 0.7 1.9 2 0 0 2 2 2 0 C2H2-type zinc finger zf-BED PF02892.15 EDO19504.1 - 9.5 6.3 12.2 3.2e+02 1.4 12.2 2.9 1 1 0 1 1 1 0 BED zinc finger Acetyltransf_1 PF00583.25 EDO19505.1 - 0.00088 19.5 0.0 0.0014 18.9 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EDO19505.1 - 0.04 14.4 0.0 0.07 13.6 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EDO19505.1 - 0.16 11.9 0.0 0.3 11.0 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain zf-C2H2 PF00096.26 EDO19506.1 - 1.6e-11 44.0 7.9 3.1e-05 24.2 0.9 3.0 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EDO19506.1 - 3.2e-06 27.5 7.0 0.0064 17.2 1.1 3.1 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EDO19506.1 - 0.00015 22.0 12.7 0.033 14.6 0.8 3.6 3 0 0 3 3 3 2 Zinc-finger double domain zf-met PF12874.7 EDO19506.1 - 0.0044 17.4 4.0 0.14 12.5 0.6 3.0 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.5 EDO19506.1 - 0.56 10.0 4.6 0.93 9.3 2.0 2.6 2 0 0 2 2 2 0 zinc-finger C2H2-type zf-C2H2_8 PF15909.5 EDO19506.1 - 1.4 9.2 6.5 0.18 12.1 1.1 2.3 3 0 0 3 3 3 0 C2H2-type zinc ribbon Malic_M PF03949.15 EDO19507.1 - 4e-86 288.5 0.0 5.5e-86 288.0 0.0 1.2 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.19 EDO19507.1 - 5.3e-64 215.4 0.0 9.2e-64 214.6 0.0 1.4 1 0 0 1 1 1 1 Malic enzyme, N-terminal domain Shikimate_DH PF01488.20 EDO19507.1 - 0.0094 16.0 0.2 1.4 9.0 0.0 3.4 4 0 0 4 4 4 1 Shikimate / quinate 5-dehydrogenase ThiF PF00899.21 EDO19508.1 - 6.7e-44 150.1 0.0 1e-43 149.5 0.0 1.1 1 0 0 1 1 1 1 ThiF family Shikimate_DH PF01488.20 EDO19508.1 - 0.00028 21.0 0.1 0.00053 20.1 0.1 1.6 1 1 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Sacchrp_dh_NADP PF03435.18 EDO19508.1 - 0.0072 16.6 0.7 0.022 15.0 0.7 1.9 1 1 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain TrkA_N PF02254.18 EDO19508.1 - 0.0087 16.3 0.0 0.02 15.1 0.0 1.6 1 0 0 1 1 1 1 TrkA-N domain UDPG_MGDP_dh_N PF03721.14 EDO19508.1 - 0.025 14.1 0.2 0.052 13.1 0.2 1.5 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain ApbA PF02558.16 EDO19508.1 - 0.055 13.1 0.0 0.1 12.3 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA NAD_binding_7 PF13241.6 EDO19508.1 - 0.083 13.3 0.0 0.21 12.0 0.0 1.7 1 0 0 1 1 1 0 Putative NAD(P)-binding DUF2370 PF10176.9 EDO19509.1 - 1.1e-67 228.0 0.0 1.1e-67 228.0 0.0 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF2370) DUF2015 PF09435.10 EDO19509.1 - 2.3 8.1 6.9 4.1 7.3 6.3 1.8 1 1 0 1 1 1 0 Fungal protein of unknown function (DUF2015) Adap_comp_sub PF00928.21 EDO19511.1 - 1.4e-32 113.2 7.1 1.1e-31 110.2 7.1 2.4 1 1 0 1 1 1 1 Adaptor complexes medium subunit family Cwf_Cwc_15 PF04889.12 EDO19511.1 - 2.4 7.8 19.0 1.6 8.4 16.9 1.7 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein DUF1754 PF08555.10 EDO19511.1 - 3.1 8.7 7.8 8.3 7.3 7.8 1.6 1 0 0 1 1 1 0 Eukaryotic family of unknown function (DUF1754) NOA36 PF06524.12 EDO19511.1 - 5.2 6.3 22.1 7.9 5.7 22.1 1.2 1 0 0 1 1 1 0 NOA36 protein SDA1 PF05285.12 EDO19511.1 - 6.2 6.1 12.1 10 5.4 12.1 1.2 1 0 0 1 1 1 0 SDA1 QCR10 PF09796.9 EDO19512.1 - 7.5e-25 86.8 0.1 9.5e-25 86.4 0.1 1.1 1 0 0 1 1 1 1 Ubiquinol-cytochrome-c reductase complex subunit (QCR10) RhodobacterPufX PF11511.8 EDO19512.1 - 0.041 13.5 0.1 0.42 10.2 0.0 2.0 2 0 0 2 2 2 0 Intrinsic membrane protein PufX PPP4R2 PF09184.11 EDO19513.1 - 0.0013 18.4 18.0 0.0013 18.4 18.0 3.8 2 2 2 4 4 4 1 PPP4R2 APS_kinase PF01583.20 EDO19514.1 - 9.5e-74 246.5 0.0 1.1e-73 246.3 0.0 1.0 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_33 PF13671.6 EDO19514.1 - 8e-07 29.3 0.0 1.3e-06 28.6 0.0 1.4 1 1 0 1 1 1 1 AAA domain KTI12 PF08433.10 EDO19514.1 - 0.00032 20.2 0.0 0.00038 20.0 0.0 1.1 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_18 PF13238.6 EDO19514.1 - 0.00041 20.9 0.0 0.00062 20.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 EDO19514.1 - 0.0017 18.1 0.0 0.0029 17.3 0.0 1.3 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.6 EDO19514.1 - 0.024 15.0 0.0 0.028 14.8 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain G-alpha PF00503.20 EDO19514.1 - 0.04 13.1 0.2 0.084 12.0 0.1 1.4 1 1 0 1 1 1 0 G-protein alpha subunit ABC_tran PF00005.27 EDO19514.1 - 0.042 14.4 0.0 0.057 13.9 0.0 1.2 1 0 0 1 1 1 0 ABC transporter CPT PF07931.12 EDO19514.1 - 0.086 12.7 0.5 0.4 10.5 0.5 2.1 1 1 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein CbiA PF01656.23 EDO19514.1 - 0.12 12.5 0.0 0.16 12.0 0.0 1.2 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain Zeta_toxin PF06414.12 EDO19514.1 - 0.15 11.3 0.0 0.24 10.6 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin Snf7 PF03357.21 EDO19515.1 - 1e-30 106.6 27.0 1.6e-30 106.0 25.5 1.8 1 1 1 2 2 2 1 Snf7 Ist1 PF03398.14 EDO19515.1 - 1.8e-07 31.2 9.2 2.8e-07 30.6 9.2 1.3 1 0 0 1 1 1 1 Regulator of Vps4 activity in the MVB pathway Uds1 PF15456.6 EDO19515.1 - 0.032 14.4 0.3 0.032 14.4 0.3 2.3 2 0 0 2 2 2 0 Up-regulated During Septation Hpt PF01627.23 EDO19515.1 - 0.037 14.3 0.5 0.037 14.3 0.5 2.1 2 1 0 2 2 2 0 Hpt domain Clathrin_H_link PF13838.6 EDO19515.1 - 0.062 13.2 0.3 0.15 12.0 0.3 1.7 1 0 0 1 1 1 0 Clathrin-H-link Remorin_C PF03763.13 EDO19515.1 - 4.6 7.2 11.3 1.5 8.8 7.5 2.0 1 1 1 2 2 2 0 Remorin, C-terminal region DUF87 PF01935.17 EDO19515.1 - 6.2 6.8 11.4 1.2 9.2 0.7 2.1 1 1 1 2 2 2 0 Helicase HerA, central domain YlqD PF11068.8 EDO19515.1 - 7.3 7.0 23.4 3.1 8.2 11.3 2.5 1 1 1 2 2 2 0 YlqD protein Ribosomal_S6 PF01250.17 EDO19516.1 - 2.1e-26 92.0 0.0 2.7e-26 91.6 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein S6 PAP2_3 PF14378.6 EDO19517.1 - 5e-25 88.3 11.8 5e-25 88.3 11.8 2.2 2 0 0 2 2 2 1 PAP2 superfamily PAP2 PF01569.21 EDO19517.1 - 1.4e-10 41.0 7.0 1.4e-10 41.0 7.0 2.4 2 1 0 2 2 2 1 PAP2 superfamily TRAM_LAG1_CLN8 PF03798.16 EDO19518.1 - 3.9e-41 141.0 27.4 3.9e-41 141.0 27.4 2.3 2 1 0 2 2 2 1 TLC domain TRAM1 PF08390.11 EDO19518.1 - 5.3e-19 67.6 1.2 1.6e-18 66.1 1.2 1.9 1 0 0 1 1 1 1 TRAM1-like protein Fimbrial_CS1 PF04449.12 EDO19518.1 - 0.056 13.6 1.0 1.2 9.3 0.1 2.4 1 1 0 2 2 2 0 CS1 type fimbrial major subunit Ribosomal_S2 PF00318.20 EDO19519.1 - 5.7e-69 231.6 0.0 2.7e-68 229.4 0.0 1.9 1 1 0 1 1 1 1 Ribosomal protein S2 DUF1599 PF07659.11 EDO19520.1 - 0.0045 17.4 3.3 0.0059 17.0 0.1 2.5 2 1 1 3 3 3 1 Nucleotide modification associated domain 1 DUF5598 PF18127.1 EDO19520.1 - 0.029 14.8 0.1 0.044 14.2 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5598) Cwf_Cwc_15 PF04889.12 EDO19520.1 - 0.5 10.1 4.5 0.69 9.6 4.5 1.4 1 1 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein RL10P_insert PF17777.1 EDO19521.1 - 1.1e-19 70.2 0.0 1.7e-19 69.5 0.0 1.4 1 0 0 1 1 1 1 Insertion domain in 60S ribosomal protein L10P Ribosomal_L10 PF00466.20 EDO19521.1 - 4.9e-17 61.9 0.0 7.8e-17 61.3 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L10 Pkinase PF00069.25 EDO19522.1 - 7e-66 222.3 2.7 1.2e-65 221.5 1.3 2.0 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO19522.1 - 1.5e-32 112.9 0.3 3.6e-32 111.7 0.3 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EDO19522.1 - 9.3e-08 31.4 2.7 9.3e-08 31.4 2.7 2.9 2 1 2 4 4 4 1 Haspin like kinase domain Kinase-like PF14531.6 EDO19522.1 - 2.8e-07 30.1 0.0 6.8e-07 28.9 0.0 1.6 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 EDO19522.1 - 0.026 14.4 0.0 0.042 13.8 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family RIO1 PF01163.22 EDO19522.1 - 0.034 13.8 0.1 0.1 12.2 0.1 1.8 1 0 0 1 1 1 0 RIO1 family Kdo PF06293.14 EDO19522.1 - 0.043 13.2 0.2 0.073 12.4 0.2 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EDO19522.1 - 0.07 11.9 0.1 0.07 11.9 0.1 2.3 3 0 0 3 3 3 0 Fungal protein kinase FTA2 PF13095.6 EDO19522.1 - 0.28 10.8 1.6 4.7 6.8 0.1 2.5 1 1 1 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 DAO PF01266.24 EDO19523.1 - 3.8e-67 227.4 0.0 6.2e-67 226.7 0.0 1.3 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EDO19523.1 - 5.5e-07 29.7 0.0 2.5e-06 27.6 0.0 2.1 1 1 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Trp_halogenase PF04820.14 EDO19523.1 - 0.00018 20.5 0.2 0.0045 15.9 0.2 2.0 2 0 0 2 2 2 1 Tryptophan halogenase Thi4 PF01946.17 EDO19523.1 - 0.0007 18.9 0.1 0.0016 17.7 0.1 1.5 2 0 0 2 2 2 1 Thi4 family MCRA PF06100.11 EDO19523.1 - 0.019 13.8 0.1 0.029 13.2 0.1 1.3 1 0 0 1 1 1 0 MCRA family Pyr_redox_2 PF07992.14 EDO19523.1 - 0.039 13.2 0.0 0.12 11.6 0.0 1.8 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EDO19523.1 - 0.085 12.9 0.1 0.23 11.4 0.0 1.7 2 0 0 2 2 2 0 FAD-NAD(P)-binding Pyr_redox PF00070.27 EDO19523.1 - 0.18 12.4 0.0 0.47 11.1 0.0 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Use1 PF09753.9 EDO19524.1 - 3e-07 30.4 4.2 3.7e-07 30.1 4.2 1.1 1 0 0 1 1 1 1 Membrane fusion protein Use1 SNARE PF05739.19 EDO19524.1 - 8.7e-05 22.4 0.3 8.7e-05 22.4 0.3 2.5 3 0 0 3 3 2 1 SNARE domain Sec20 PF03908.13 EDO19524.1 - 0.00027 20.8 2.3 0.02 14.8 0.1 2.5 2 1 0 2 2 2 1 Sec20 Prominin PF05478.11 EDO19524.1 - 0.0024 15.9 5.5 0.003 15.6 5.5 1.1 1 0 0 1 1 1 1 Prominin Syntaxin_2 PF14523.6 EDO19524.1 - 0.023 15.1 8.0 2 8.8 3.5 2.4 2 1 0 2 2 2 0 Syntaxin-like protein THOC7 PF05615.13 EDO19524.1 - 0.029 14.7 0.8 0.029 14.7 0.8 2.7 2 1 0 2 2 2 0 Tho complex subunit 7 Focal_AT PF03623.13 EDO19524.1 - 0.031 14.3 0.5 0.061 13.3 0.2 1.7 2 0 0 2 2 2 0 Focal adhesion targeting region V-SNARE_C PF12352.8 EDO19524.1 - 0.063 13.6 3.6 0.2 11.9 0.8 2.3 2 0 0 2 2 2 0 Snare region anchored in the vesicle membrane C-terminus Aminopep PF10023.9 EDO19524.1 - 0.063 12.6 1.8 0.088 12.2 1.8 1.3 1 0 0 1 1 1 0 Putative aminopeptidase NPV_P10 PF05531.12 EDO19524.1 - 0.08 13.4 4.2 0.24 11.9 0.1 3.0 1 1 3 4 4 4 0 Nucleopolyhedrovirus P10 protein DUF1043 PF06295.12 EDO19524.1 - 0.1 12.6 2.7 0.57 10.2 0.1 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF1043) Lipase_GDSL PF00657.22 EDO19524.1 - 0.11 12.5 1.6 0.17 11.8 1.6 1.3 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase Syntaxin-6_N PF09177.11 EDO19524.1 - 0.12 12.9 8.9 0.67 10.5 4.5 2.9 1 1 1 2 2 2 0 Syntaxin 6, N-terminal PhaP_Bmeg PF09602.10 EDO19524.1 - 0.15 12.0 10.4 0.043 13.7 3.4 2.3 1 1 1 2 2 2 0 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) DUF1664 PF07889.12 EDO19524.1 - 0.15 12.1 8.3 1.3 9.1 0.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Laminin_II PF06009.12 EDO19524.1 - 0.29 11.2 7.2 11 6.1 3.8 2.7 1 1 0 2 2 2 0 Laminin Domain II PARP_reg PF02877.14 EDO19524.1 - 0.29 11.2 4.9 0.25 11.4 0.5 2.3 1 1 1 2 2 2 0 Poly(ADP-ribose) polymerase, regulatory domain DUF745 PF05335.13 EDO19524.1 - 0.37 10.5 2.6 4.8 6.9 0.3 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF745) RmuC PF02646.16 EDO19524.1 - 0.4 9.8 8.2 0.49 9.5 0.2 2.6 2 1 0 2 2 2 0 RmuC family Seryl_tRNA_N PF02403.22 EDO19524.1 - 0.46 10.7 11.0 0.59 10.4 4.1 2.7 2 1 1 3 3 3 0 Seryl-tRNA synthetase N-terminal domain Spc7 PF08317.11 EDO19524.1 - 0.58 9.0 15.5 0.44 9.4 6.6 2.1 1 1 0 2 2 2 0 Spc7 kinetochore protein DUF643 PF04867.12 EDO19524.1 - 0.63 10.7 5.9 0.58 10.8 2.2 2.3 1 1 0 2 2 2 0 Protein of unknown function (DUF643) Med9 PF07544.13 EDO19524.1 - 0.64 10.1 12.0 0.55 10.4 0.6 3.4 2 1 1 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 Occludin_ELL PF07303.13 EDO19524.1 - 0.86 10.4 10.5 8.8 7.1 2.5 2.8 2 1 1 3 3 3 0 Occludin homology domain DUF2650 PF10853.8 EDO19524.1 - 1.1 9.0 3.6 1.8 8.4 3.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2650) DUF148 PF02520.17 EDO19524.1 - 1.6 8.9 7.2 1.2 9.3 2.6 2.6 2 1 1 3 3 3 0 Domain of unknown function DUF148 TMPIT PF07851.13 EDO19524.1 - 1.8 7.8 7.3 4.7 6.4 2.8 2.1 1 1 1 2 2 2 0 TMPIT-like protein FlaC_arch PF05377.11 EDO19524.1 - 3.2 8.2 14.7 0.86 10.0 1.5 4.1 4 1 1 5 5 5 0 Flagella accessory protein C (FlaC) eIF3_N PF09440.10 EDO19524.1 - 3.2 8.2 6.7 3.1 8.2 2.2 2.1 2 0 0 2 2 2 0 eIF3 subunit 6 N terminal domain DUF5446 PF17522.2 EDO19524.1 - 3.7 7.8 14.6 5.2 7.3 5.6 3.5 3 1 1 4 4 3 0 Family of unknown function (DUF5446) YabA PF06156.13 EDO19524.1 - 4.4 8.0 10.0 9.5 6.9 0.4 2.6 1 1 1 2 2 2 0 Initiation control protein YabA ATG16 PF08614.11 EDO19524.1 - 5.1 7.3 14.3 3.4 7.8 5.5 2.6 1 1 0 2 2 2 0 Autophagy protein 16 (ATG16) Dpy-30 PF05186.13 EDO19525.1 - 3.8e-15 55.3 0.1 5.4e-15 54.8 0.1 1.2 1 0 0 1 1 1 1 Dpy-30 motif Mito_carr PF00153.27 EDO19526.1 - 3.9e-09 36.3 0.0 0.00048 20.0 0.0 3.6 3 1 0 3 3 3 2 Mitochondrial carrier protein Gon7 PF08738.10 EDO19527.1 - 0.0052 16.8 0.6 0.016 15.3 0.6 1.8 1 0 0 1 1 1 1 Gon7 family YvbH_ext PF11724.8 EDO19527.1 - 0.049 13.9 0.1 1.1 9.6 0.0 2.6 2 0 0 2 2 2 0 YvbH-like oligomerisation region BLOC1_2 PF10046.9 EDO19527.1 - 0.37 11.1 19.3 0.58 10.5 1.6 3.7 2 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DHR10 PF18595.1 EDO19527.1 - 0.41 10.7 9.0 3 7.9 7.9 2.7 1 1 1 2 2 2 0 Designed helical repeat protein 10 domain CHD5 PF04420.14 EDO19527.1 - 1 9.2 3.8 7.8 6.3 0.4 2.4 2 0 0 2 2 2 0 CHD5-like protein XhlA PF10779.9 EDO19527.1 - 2.7 8.3 9.1 0.17 12.1 1.6 2.9 2 2 0 2 2 2 0 Haemolysin XhlA DUF1664 PF07889.12 EDO19527.1 - 4.7 7.3 9.7 3.3 7.7 1.9 3.4 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) Ribosomal_L27e PF01777.18 EDO19528.1 - 2e-35 121.0 8.3 2.9e-35 120.5 8.3 1.2 1 0 0 1 1 1 1 Ribosomal L27e protein family KOW PF00467.29 EDO19528.1 - 0.00031 20.6 0.9 0.00057 19.8 0.9 1.4 1 0 0 1 1 1 1 KOW motif TRAPP PF04051.16 EDO19529.1 - 2.4e-41 140.9 0.0 3.3e-41 140.4 0.0 1.2 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component FSA_C PF10479.9 EDO19530.1 - 1.9 6.6 10.6 3.1 5.8 10.6 1.3 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus DUF3439 PF11921.8 EDO19530.1 - 2.1 8.3 8.6 5.4 7.0 8.6 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) DDHD PF02862.17 EDO19531.1 - 7.1e-39 134.3 3.0 2.1e-24 86.9 0.3 3.1 2 1 1 3 3 3 2 DDHD domain LCAT PF02450.15 EDO19531.1 - 0.00014 21.2 0.9 0.001 18.3 0.0 2.4 3 0 0 3 3 3 1 Lecithin:cholesterol acyltransferase PGAP1 PF07819.13 EDO19531.1 - 0.0017 18.1 0.0 0.0042 16.8 0.0 1.6 1 0 0 1 1 1 1 PGAP1-like protein LIDHydrolase PF10230.9 EDO19531.1 - 0.0093 15.5 0.0 0.019 14.5 0.0 1.4 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase FAST_2 PF08368.12 EDO19531.1 - 0.019 15.8 0.4 0.18 12.6 0.1 2.7 2 1 1 3 3 3 0 FAST kinase-like protein, subdomain 2 WWE PF02825.20 EDO19531.1 - 0.032 14.8 0.7 0.1 13.2 0.0 2.2 3 0 0 3 3 3 0 WWE domain TSC22 PF01166.18 EDO19531.1 - 0.059 13.7 3.7 0.2 12.0 0.1 2.9 3 0 0 3 3 3 0 TSC-22/dip/bun family Palm_thioest PF02089.15 EDO19531.1 - 0.061 13.2 0.0 0.26 11.1 0.0 1.9 2 0 0 2 2 2 0 Palmitoyl protein thioesterase Hydrolase_4 PF12146.8 EDO19531.1 - 0.11 11.7 0.0 1.1 8.4 0.0 2.1 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Corona_nucleoca PF00937.18 EDO19532.1 - 0.00011 21.4 1.2 0.00011 21.4 1.2 2.3 2 0 0 2 2 2 1 Coronavirus nucleocapsid protein DUF2963 PF11178.8 EDO19532.1 - 0.064 13.0 1.9 0.35 10.6 1.1 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2963) Pkinase PF00069.25 EDO19533.1 - 2.9e-75 253.1 0.1 4.3e-75 252.5 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain AdenylateSensor PF16579.5 EDO19533.1 - 8.7e-56 187.4 0.1 2.2e-55 186.1 0.1 1.7 1 0 0 1 1 1 1 Adenylate sensor of SNF1-like protein kinase Pkinase_Tyr PF07714.17 EDO19533.1 - 3.4e-38 131.4 0.0 4.9e-38 130.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase UBA_2 PF08587.11 EDO19533.1 - 3.7e-19 68.5 0.8 3.7e-19 68.5 0.8 2.2 2 0 0 2 2 2 1 Ubiquitin associated domain (UBA) Kinase-like PF14531.6 EDO19533.1 - 1.7e-10 40.7 0.0 4e-10 39.5 0.0 1.6 1 1 0 1 1 1 1 Kinase-like RIO1 PF01163.22 EDO19533.1 - 5.2e-05 22.9 0.7 0.0001 22.0 0.7 1.4 1 0 0 1 1 1 1 RIO1 family YukC PF10140.9 EDO19533.1 - 0.00055 18.9 1.1 0.00085 18.3 1.1 1.2 1 0 0 1 1 1 1 WXG100 protein secretion system (Wss), protein YukC Kdo PF06293.14 EDO19533.1 - 0.0022 17.4 0.2 0.0037 16.6 0.2 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EDO19533.1 - 0.0029 17.6 0.1 0.21 11.5 0.1 2.3 1 1 1 2 2 2 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EDO19533.1 - 0.0086 15.1 1.3 0.0086 15.1 1.3 2.0 2 1 0 2 2 2 1 Haspin like kinase domain Pex24p PF06398.11 EDO19534.1 - 9.4e-84 281.5 6.8 1.1e-83 281.2 6.8 1.1 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin Rabaptin PF03528.15 EDO19534.1 - 0.031 13.0 2.0 0.048 12.4 2.0 1.2 1 0 0 1 1 1 0 Rabaptin WD40_like PF17005.5 EDO19535.1 - 4.2e-08 32.9 2.1 3.6e-05 23.3 0.3 2.2 1 1 1 2 2 2 2 WD40-like domain WD40 PF00400.32 EDO19535.1 - 2e-05 25.2 9.3 0.012 16.4 0.2 5.5 6 0 0 6 6 6 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDO19535.1 - 0.001 19.3 0.3 3.3 8.1 0.0 4.8 1 1 5 6 6 6 1 Anaphase-promoting complex subunit 4 WD40 domain NikR_C PF08753.11 EDO19535.1 - 0.024 14.8 0.1 0.048 13.8 0.1 1.4 1 0 0 1 1 1 0 NikR C terminal nickel binding domain PQQ PF01011.21 EDO19535.1 - 0.071 13.1 0.4 3.2 7.8 0.0 3.4 5 0 0 5 5 5 0 PQQ enzyme repeat SET PF00856.28 EDO19536.1 - 5.1e-18 66.0 0.0 1.1e-17 64.9 0.0 1.6 2 0 0 2 2 2 1 SET domain DUF1374 PF07118.11 EDO19536.1 - 0.023 15.2 1.0 5 7.7 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1374) TPR_1 PF00515.28 EDO19537.1 - 5.2e-43 143.2 18.6 2.5e-07 30.2 0.0 9.6 9 0 0 9 9 9 6 Tetratricopeptide repeat STI1 PF17830.1 EDO19537.1 - 2.6e-36 123.4 16.9 2e-18 66.1 5.2 2.9 2 0 0 2 2 2 2 STI1 domain TPR_2 PF07719.17 EDO19537.1 - 5.7e-34 113.5 20.4 0.00016 21.6 0.1 9.3 9 0 0 9 9 9 8 Tetratricopeptide repeat TPR_12 PF13424.6 EDO19537.1 - 1.7e-21 76.2 3.8 4.3e-07 30.1 0.0 6.5 4 2 2 6 6 6 3 Tetratricopeptide repeat TPR_11 PF13414.6 EDO19537.1 - 2e-19 69.0 17.4 0.00094 18.8 0.0 7.9 7 1 0 7 7 7 5 TPR repeat TPR_8 PF13181.6 EDO19537.1 - 3.6e-18 64.2 13.8 0.00099 19.1 0.1 8.3 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_16 PF13432.6 EDO19537.1 - 4.2e-18 65.7 2.8 3.8e-05 24.2 0.0 6.6 5 1 1 6 6 6 4 Tetratricopeptide repeat TPR_19 PF14559.6 EDO19537.1 - 9.6e-15 54.9 11.4 0.0015 19.0 0.1 7.3 5 2 2 7 7 7 4 Tetratricopeptide repeat TPR_14 PF13428.6 EDO19537.1 - 2.7e-14 52.6 6.2 1.1 10.3 0.1 8.5 4 2 4 8 8 8 3 Tetratricopeptide repeat TPR_7 PF13176.6 EDO19537.1 - 6.7e-13 47.7 7.5 0.0002 21.2 0.0 6.8 8 0 0 8 8 6 2 Tetratricopeptide repeat TPR_17 PF13431.6 EDO19537.1 - 2.5e-10 40.0 2.6 0.21 12.1 0.0 7.1 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_10 PF13374.6 EDO19537.1 - 2.6e-08 33.5 1.6 0.17 11.8 0.1 7.1 8 0 0 8 8 8 1 Tetratricopeptide repeat TPR_9 PF13371.6 EDO19537.1 - 1.8e-06 28.0 0.1 0.0017 18.5 0.0 4.1 4 1 0 4 4 3 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EDO19537.1 - 2.4e-05 24.5 10.1 0.19 12.0 0.2 4.7 2 1 3 5 5 5 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 EDO19537.1 - 4.5e-05 23.8 16.0 4.2 8.2 0.0 7.7 9 0 0 9 9 7 1 Tetratricopeptide repeat DUF3808 PF10300.9 EDO19537.1 - 0.00018 20.4 0.1 0.00018 20.4 0.1 2.6 2 1 0 2 2 2 1 Protein of unknown function (DUF3808) PPR PF01535.20 EDO19537.1 - 0.045 14.0 4.7 16 6.0 0.0 5.5 6 0 0 6 6 6 0 PPR repeat DnaI_N PF07319.11 EDO19537.1 - 0.051 14.2 12.0 5.2 7.8 0.2 5.0 4 1 0 5 5 5 0 Primosomal protein DnaI N-terminus DUF5113 PF17140.4 EDO19537.1 - 0.098 12.5 4.7 0.3 10.9 0.1 3.5 2 1 1 4 4 4 0 Domain of unknown function (DUF5113) TcdB_N PF12918.7 EDO19537.1 - 0.11 12.9 0.7 0.79 10.0 0.2 2.7 2 1 0 2 2 2 0 TcdB toxin N-terminal helical domain PPR_2 PF13041.6 EDO19537.1 - 0.27 11.5 1.7 33 4.8 0.0 4.1 4 0 0 4 4 4 0 PPR repeat family XPC-binding PF09280.11 EDO19537.1 - 0.53 10.1 8.9 0.16 11.7 2.9 2.8 2 1 0 2 2 2 0 XPC-binding domain MAS20 PF02064.15 EDO19537.1 - 1.8 8.7 0.0 1.8 8.7 0.0 4.6 4 1 1 5 5 4 0 MAS20 protein import receptor AAA_2 PF07724.14 EDO19538.1 - 3.3e-51 173.8 0.1 3.6e-49 167.2 0.0 2.7 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_lid_9 PF17871.1 EDO19538.1 - 2.9e-35 120.3 7.7 4.1e-35 119.8 1.1 2.8 2 0 0 2 2 2 1 AAA lid domain ClpB_D2-small PF10431.9 EDO19538.1 - 5.9e-25 87.1 0.3 2.2e-24 85.3 0.3 2.1 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA PF00004.29 EDO19538.1 - 5.5e-21 75.4 0.1 1.3e-10 41.8 0.0 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 EDO19538.1 - 1.3e-15 57.6 0.2 8.7e-12 45.2 0.0 3.4 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EDO19538.1 - 6.1e-10 39.7 1.0 0.00047 20.6 0.1 3.5 2 2 2 4 4 3 2 AAA ATPase domain TniB PF05621.11 EDO19538.1 - 1e-06 28.3 0.1 0.00083 18.8 0.0 3.9 3 1 0 3 3 3 1 Bacterial TniB protein Sigma54_activat PF00158.26 EDO19538.1 - 1.2e-06 28.4 0.0 5.5e-05 22.9 0.0 2.5 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_14 PF13173.6 EDO19538.1 - 1.9e-06 27.9 0.0 0.015 15.3 0.0 3.0 2 1 0 2 2 2 2 AAA domain AAA_22 PF13401.6 EDO19538.1 - 5.2e-06 26.8 0.2 0.2 11.9 0.1 3.4 2 2 0 2 2 2 2 AAA domain IstB_IS21 PF01695.17 EDO19538.1 - 9.8e-06 25.4 0.1 0.066 12.9 0.0 2.8 3 0 0 3 3 3 2 IstB-like ATP binding protein AAA_7 PF12775.7 EDO19538.1 - 3e-05 23.6 0.2 0.048 13.2 0.0 2.9 2 1 0 2 2 2 2 P-loop containing dynein motor region ATPase_2 PF01637.18 EDO19538.1 - 3.3e-05 23.9 7.5 0.22 11.4 0.0 4.4 3 2 1 5 5 5 2 ATPase domain predominantly from Archaea RsgA_GTPase PF03193.16 EDO19538.1 - 5.3e-05 23.2 0.0 0.044 13.7 0.0 2.9 2 0 0 2 2 2 1 RsgA GTPase AAA_18 PF13238.6 EDO19538.1 - 0.00013 22.5 4.9 0.26 11.8 0.0 4.1 4 1 0 4 4 3 2 AAA domain ABC_tran PF00005.27 EDO19538.1 - 0.00041 20.9 3.4 0.24 11.9 0.0 3.5 3 1 0 3 3 3 1 ABC transporter TsaE PF02367.17 EDO19538.1 - 0.00045 20.2 0.0 1.5 8.8 0.0 2.6 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE NACHT PF05729.12 EDO19538.1 - 0.00046 20.1 0.0 0.17 11.8 0.0 2.5 2 0 0 2 2 2 1 NACHT domain Roc PF08477.13 EDO19538.1 - 0.00058 20.1 0.0 1.2 9.3 0.0 2.7 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase AAA_29 PF13555.6 EDO19538.1 - 0.00063 19.4 0.0 0.14 11.9 0.0 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain RNA_helicase PF00910.22 EDO19538.1 - 0.00087 19.7 0.0 1.5 9.2 0.0 3.0 2 0 0 2 2 2 1 RNA helicase AAA_28 PF13521.6 EDO19538.1 - 0.00089 19.5 0.0 0.47 10.7 0.0 2.8 2 0 0 2 2 2 1 AAA domain PduV-EutP PF10662.9 EDO19538.1 - 0.00097 18.9 0.0 0.41 10.4 0.0 2.6 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation AAA_30 PF13604.6 EDO19538.1 - 0.001 18.8 0.0 1.5 8.5 0.0 3.1 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 EDO19538.1 - 0.0031 17.9 0.2 3.5 8.0 0.1 3.6 2 2 1 3 3 3 1 AAA domain AAA_6 PF12774.7 EDO19538.1 - 0.0044 16.0 0.1 0.19 10.7 0.0 2.8 3 0 0 3 3 3 1 Hydrolytic ATP binding site of dynein motor region AAA_25 PF13481.6 EDO19538.1 - 0.0048 16.5 0.1 0.22 11.0 0.0 2.9 3 0 0 3 3 3 1 AAA domain Mg_chelatase PF01078.21 EDO19538.1 - 0.0063 15.9 0.1 0.76 9.1 0.0 2.9 2 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI DUF815 PF05673.13 EDO19538.1 - 0.0077 15.4 0.7 0.79 8.8 0.2 3.1 2 2 0 2 2 2 1 Protein of unknown function (DUF815) ResIII PF04851.15 EDO19538.1 - 0.0084 16.1 0.1 1.5 8.8 0.0 3.7 4 0 0 4 4 4 1 Type III restriction enzyme, res subunit Zeta_toxin PF06414.12 EDO19538.1 - 0.0097 15.2 0.0 0.15 11.4 0.0 2.6 2 0 0 2 2 2 1 Zeta toxin AAA_24 PF13479.6 EDO19538.1 - 0.011 15.4 0.4 7.4 6.2 0.0 3.1 3 0 0 3 3 3 0 AAA domain SRP54 PF00448.22 EDO19538.1 - 0.011 15.3 0.0 2.1 7.9 0.0 2.7 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain MMR_HSR1 PF01926.23 EDO19538.1 - 0.02 15.0 0.5 3.6 7.7 0.1 3.8 3 1 0 3 3 3 0 50S ribosome-binding GTPase AAA_21 PF13304.6 EDO19538.1 - 0.025 14.4 5.6 0.61 9.8 0.1 3.9 3 1 1 4 4 4 0 AAA domain, putative AbiEii toxin, Type IV TA system Torsin PF06309.11 EDO19538.1 - 0.039 14.1 0.0 0.087 12.9 0.0 1.5 1 0 0 1 1 1 0 Torsin T2SSE PF00437.20 EDO19538.1 - 0.044 12.8 2.6 0.14 11.2 1.3 2.5 2 1 0 2 2 2 0 Type II/IV secretion system protein AAA_33 PF13671.6 EDO19538.1 - 0.048 13.8 0.0 8.1 6.6 0.0 2.9 2 0 0 2 2 2 0 AAA domain PhoH PF02562.16 EDO19538.1 - 0.055 12.9 0.0 2.9 7.3 0.0 2.7 2 0 0 2 2 2 0 PhoH-like protein LacI PF00356.21 EDO19538.1 - 0.092 12.6 0.0 4.6 7.1 0.0 2.8 2 0 0 2 2 2 0 Bacterial regulatory proteins, lacI family ATP_bind_1 PF03029.17 EDO19538.1 - 0.1 12.4 0.0 14 5.3 0.0 2.5 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_3 PF07726.11 EDO19538.1 - 0.1 12.5 0.0 1.9 8.3 0.0 2.8 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Ribosomal_L3 PF00297.22 EDO19539.1 - 7.6e-190 630.6 10.9 8.6e-190 630.4 10.9 1.0 1 0 0 1 1 1 1 Ribosomal protein L3 PHD PF00628.29 EDO19540.1 - 8.1e-05 22.4 7.4 0.00015 21.6 7.4 1.5 1 0 0 1 1 1 1 PHD-finger zf-HC5HC2H PF13771.6 EDO19540.1 - 0.031 14.5 1.1 0.031 14.5 1.1 2.3 1 1 1 2 2 2 0 PHD-like zinc-binding domain Alg6_Alg8 PF03155.15 EDO19541.1 - 1.7e-168 561.6 40.8 2e-168 561.4 40.8 1.0 1 0 0 1 1 1 1 ALG6, ALG8 glycosyltransferase family Vps5 PF09325.10 EDO19542.1 - 6.9e-44 150.2 7.3 1e-43 149.6 7.3 1.2 1 0 0 1 1 1 1 Vps5 C terminal like PX PF00787.24 EDO19542.1 - 1.1e-23 83.4 0.0 2.9e-23 82.0 0.0 1.7 1 0 0 1 1 1 1 PX domain RabGAP-TBC PF00566.18 EDO19543.1 - 6.3e-52 176.3 1.2 6.3e-52 176.3 1.2 1.9 2 0 0 2 2 2 1 Rab-GTPase-TBC domain Brix PF04427.18 EDO19544.1 - 4.8e-39 134.5 1.5 6.9e-39 134.0 1.5 1.2 1 0 0 1 1 1 1 Brix domain DUF1086 PF06461.11 EDO19544.1 - 0.054 13.3 0.7 0.12 12.3 0.3 1.8 1 1 1 2 2 2 0 Domain of Unknown Function (DUF1086) Nucleoporin_N PF08801.11 EDO19545.1 - 3.7e-73 246.7 14.0 3.7e-73 246.7 14.0 1.8 2 0 0 2 2 2 1 Nup133 N terminal like Nucleoporin_C PF03177.14 EDO19545.1 - 1.1e-19 70.6 8.8 1.1e-19 70.6 8.8 2.0 2 0 0 2 2 2 1 Non-repetitive/WGA-negative nucleoporin C-terminal DASH_Dad2 PF08654.10 EDO19546.1 - 4.1e-29 100.9 0.6 4.6e-29 100.8 0.6 1.0 1 0 0 1 1 1 1 DASH complex subunit Dad2 DASH_Duo1 PF08651.10 EDO19546.1 - 0.00033 20.4 2.2 0.00046 19.9 2.2 1.2 1 0 0 1 1 1 1 DASH complex subunit Duo1 Rogdi_lz PF10259.9 EDO19546.1 - 0.001 18.6 0.2 0.0012 18.4 0.2 1.0 1 0 0 1 1 1 1 Rogdi leucine zipper containing protein FPP PF05911.11 EDO19546.1 - 0.007 14.6 0.1 0.0077 14.5 0.1 1.0 1 0 0 1 1 1 1 Filament-like plant protein, long coiled-coil YtzH PF14165.6 EDO19546.1 - 0.011 16.2 1.8 0.013 15.9 1.8 1.1 1 0 0 1 1 1 0 YtzH-like protein BORCS7 PF16088.5 EDO19546.1 - 0.058 13.7 3.4 4.8 7.5 0.5 2.1 1 1 1 2 2 2 0 BLOC-1-related complex sub-unit 7 DUF948 PF06103.11 EDO19546.1 - 0.058 13.6 0.6 0.073 13.3 0.6 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) Shugoshin_N PF07558.11 EDO19547.1 - 1.7e-13 50.2 5.7 1.7e-13 50.2 5.7 2.4 2 0 0 2 2 2 1 Shugoshin N-terminal coiled-coil region Shugoshin_C PF07557.11 EDO19547.1 - 2.4e-08 33.6 4.6 5.5e-08 32.5 4.6 1.7 1 0 0 1 1 1 1 Shugoshin C terminus CDC45 PF02724.14 EDO19547.1 - 0.0043 15.4 12.3 0.0052 15.2 12.3 1.2 1 0 0 1 1 1 1 CDC45-like protein CHZ PF09649.10 EDO19547.1 - 0.068 12.7 0.4 0.39 10.2 0.1 2.5 2 0 0 2 2 2 0 Histone chaperone domain CHZ HNF-1A_C PF04813.12 EDO19547.1 - 0.075 13.8 2.6 0.37 11.6 2.6 2.2 1 0 0 1 1 1 0 Hepatocyte nuclear factor 1 (HNF-1), alpha isoform C terminus Trypan_PARP PF05887.11 EDO19547.1 - 0.16 12.0 15.7 0.4 10.7 15.7 1.7 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) SID-1_RNA_chan PF13965.6 EDO19547.1 - 0.25 9.7 7.5 0.38 9.1 7.5 1.4 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 TEX19 PF15553.6 EDO19547.1 - 6.4 6.7 11.9 15 5.5 11.9 1.6 1 0 0 1 1 1 0 Testis-expressed protein 19 Connexin PF00029.19 EDO19547.1 - 8 6.1 12.7 18 5.0 12.7 1.6 1 0 0 1 1 1 0 Connexin Thymidylat_synt PF00303.19 EDO19548.1 - 1.1e-115 385.4 0.0 1.3e-115 385.2 0.0 1.0 1 0 0 1 1 1 1 Thymidylate synthase Syntaxin-18_N PF10496.9 EDO19549.1 - 7.7e-14 51.7 0.4 7.7e-14 51.7 0.4 2.6 3 1 0 3 3 3 1 SNARE-complex protein Syntaxin-18 N-terminus SNARE PF05739.19 EDO19549.1 - 1.2e-05 25.2 0.4 7.3e-05 22.7 0.2 2.5 2 0 0 2 2 2 1 SNARE domain GP24_25 PF17388.2 EDO19549.1 - 0.18 11.8 8.8 0.11 12.4 1.2 2.3 2 0 0 2 2 2 0 Tail assembly gene products 24 & 25 Spore_III_AB PF09548.10 EDO19549.1 - 1.7 8.7 13.1 1.7 8.7 8.7 2.9 2 1 0 2 2 2 0 Stage III sporulation protein AB (spore_III_AB) Sec20 PF03908.13 EDO19549.1 - 1.7 8.6 18.3 0.15 12.0 0.8 4.3 2 2 3 5 5 5 0 Sec20 Snapin_Pallidin PF14712.6 EDO19549.1 - 1.9 8.9 25.8 0.31 11.5 6.9 4.2 3 1 1 4 4 4 0 Snapin/Pallidin Peptidase_M41 PF01434.18 EDO19549.1 - 3.8 7.3 13.3 4.4 7.1 1.9 2.5 2 0 0 2 2 2 0 Peptidase family M41 DUF4358 PF14270.6 EDO19549.1 - 5.9 7.2 11.6 0.53 10.6 1.0 3.4 2 1 1 3 3 3 0 Domain of unknown function (DUF4358) MRP-L20 PF12824.7 EDO19551.1 - 7.4e-52 175.8 2.3 8.7e-52 175.6 2.3 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal protein subunit L20 Nup88 PF10168.9 EDO19551.1 - 0.029 12.2 0.6 0.037 11.9 0.6 1.1 1 0 0 1 1 1 0 Nuclear pore component HA2 PF04408.23 EDO19552.1 - 9.8e-21 74.1 0.0 3.1e-20 72.4 0.0 1.9 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 EDO19552.1 - 8.7e-18 64.5 0.0 2.7e-17 62.9 0.0 1.9 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 EDO19552.1 - 9.8e-13 48.4 0.3 7.6e-12 45.6 0.1 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 EDO19552.1 - 1.3e-05 25.0 0.1 6.2e-05 22.8 0.1 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase AAA_22 PF13401.6 EDO19552.1 - 2.2e-05 24.8 0.0 0.00011 22.5 0.0 2.2 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 EDO19552.1 - 0.0026 16.9 0.0 0.0047 16.0 0.0 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_30 PF13604.6 EDO19552.1 - 0.014 15.1 0.0 0.028 14.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain SRP54 PF00448.22 EDO19552.1 - 0.014 15.0 0.1 0.053 13.2 0.0 1.9 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain DUF2075 PF09848.9 EDO19552.1 - 0.022 14.0 0.0 0.043 13.1 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_19 PF13245.6 EDO19552.1 - 0.027 14.8 0.0 0.062 13.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 EDO19552.1 - 0.028 13.9 0.0 0.079 12.4 0.0 1.7 1 0 0 1 1 1 0 PhoH-like protein AAA_33 PF13671.6 EDO19552.1 - 0.032 14.4 0.1 0.28 11.3 0.0 2.6 2 1 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 EDO19552.1 - 0.041 13.6 0.2 2.2 8.0 0.0 2.3 1 1 1 2 2 2 0 IstB-like ATP binding protein Reprolysin PF01421.19 EDO19552.1 - 0.064 13.2 0.2 0.18 11.7 0.0 1.8 2 0 0 2 2 2 0 Reprolysin (M12B) family zinc metalloprotease AAA_16 PF13191.6 EDO19552.1 - 0.15 12.4 0.0 0.33 11.3 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain Peptidase_M48 PF01435.18 EDO19553.1 - 9.9e-30 103.8 0.0 2.4e-29 102.5 0.0 1.6 1 1 0 1 1 1 1 Peptidase family M48 MtaB PF12176.8 EDO19554.1 - 0.045 12.5 0.0 0.045 12.5 0.0 1.0 1 0 0 1 1 1 0 Methanol-cobalamin methyltransferase B subunit Proteasome PF00227.26 EDO19555.1 - 4.5e-41 140.4 0.0 5.4e-41 140.2 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit Sec7 PF01369.20 EDO19556.1 - 2.6e-15 56.6 0.0 5.7e-15 55.5 0.0 1.5 1 0 0 1 1 1 1 Sec7 domain PH_9 PF15410.6 EDO19556.1 - 0.043 14.2 0.3 0.15 12.4 0.1 2.0 2 0 0 2 2 2 0 Pleckstrin homology domain T2SSG PF08334.11 EDO19556.1 - 0.11 12.5 0.0 0.28 11.3 0.0 1.6 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein G Rad51 PF08423.11 EDO19557.1 - 2.6e-128 426.7 0.0 3.2e-128 426.4 0.0 1.1 1 0 0 1 1 1 1 Rad51 RecA PF00154.21 EDO19557.1 - 3.4e-12 46.4 0.0 5.1e-12 45.8 0.0 1.2 1 0 0 1 1 1 1 recA bacterial DNA recombination protein AAA_25 PF13481.6 EDO19557.1 - 1.3e-09 37.9 0.0 2e-09 37.3 0.0 1.2 1 0 0 1 1 1 1 AAA domain HHH_5 PF14520.6 EDO19557.1 - 1.4e-07 32.0 0.1 2.7e-07 31.1 0.1 1.4 1 0 0 1 1 1 1 Helix-hairpin-helix domain ATPase PF06745.13 EDO19557.1 - 1.3e-05 24.7 0.0 2.5e-05 23.7 0.0 1.5 1 1 0 1 1 1 1 KaiC DnaB_C PF03796.15 EDO19557.1 - 0.005 16.2 0.1 0.013 14.8 0.0 1.6 2 0 0 2 2 2 1 DnaB-like helicase C terminal domain AAA_24 PF13479.6 EDO19557.1 - 0.083 12.6 0.0 0.18 11.5 0.0 1.5 1 1 0 1 1 1 0 AAA domain Sel1 PF08238.12 EDO19558.1 - 1.9e-38 130.0 17.6 2.1e-07 31.4 1.0 7.3 7 0 0 7 7 7 7 Sel1 repeat DUF5532 PF17673.1 EDO19558.1 - 0.042 13.9 0.6 2 8.5 0.2 2.6 2 0 0 2 2 2 0 Family of unknown function (DUF5532) TPR_6 PF13174.6 EDO19558.1 - 5.1 8.0 6.4 30 5.5 0.1 4.4 4 1 1 5 5 5 0 Tetratricopeptide repeat Fungal_trans PF04082.18 EDO19559.1 - 3.3e-17 62.4 4.3 3.3e-17 62.4 4.3 2.3 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDO19559.1 - 8e-09 35.5 9.5 1.4e-08 34.7 9.5 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain UCH PF00443.29 EDO19560.1 - 1.2e-59 201.9 21.2 9.3e-59 199.0 21.2 2.4 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EDO19560.1 - 1.1e-16 61.3 30.4 7e-14 52.1 30.4 2.9 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase YnfE PF17452.2 EDO19560.1 - 0.022 15.0 1.4 0.11 12.8 0.5 2.5 2 0 0 2 2 2 0 Uncharacterized YnfE-like TetR_C_19 PF17924.1 EDO19560.1 - 0.037 14.6 0.7 0.037 14.6 0.7 4.1 4 1 1 5 5 5 0 Tetracyclin repressor-like, C-terminal domain ADH_zinc_N_2 PF13602.6 EDO19561.1 - 2.3e-13 51.4 0.0 4.3e-13 50.5 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EDO19561.1 - 9.9e-05 22.2 0.0 0.0002 21.2 0.0 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EDO19561.1 - 0.038 14.0 0.1 1 9.3 0.0 2.8 2 1 1 3 3 3 0 Zinc-binding dehydrogenase Ribosomal_S8e PF01201.22 EDO19562.1 - 7.7e-56 188.1 3.0 8.9e-56 187.8 3.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S8e AAR2 PF05282.11 EDO19563.1 - 5.7e-32 111.5 4.9 9.1e-32 110.8 4.9 1.2 1 0 0 1 1 1 1 AAR2 protein HSP70 PF00012.20 EDO19564.1 - 4.4e-261 867.3 10.0 5e-261 867.1 10.0 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EDO19564.1 - 2.8e-16 59.2 0.0 3.2e-15 55.8 0.0 2.0 2 0 0 2 2 2 1 MreB/Mbl protein FGGY_C PF02782.16 EDO19564.1 - 0.0019 18.0 0.0 0.0037 17.0 0.0 1.6 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain DDR PF08841.10 EDO19564.1 - 0.018 14.1 0.6 0.12 11.3 0.2 2.1 2 0 0 2 2 2 0 Diol dehydratase reactivase ATPase-like domain BcrAD_BadFG PF01869.20 EDO19564.1 - 0.031 13.8 0.0 3.8 6.9 0.0 2.4 2 0 0 2 2 2 0 BadF/BadG/BcrA/BcrD ATPase family Hydantoinase_A PF01968.18 EDO19564.1 - 0.032 13.5 0.2 0.1 11.9 0.2 1.9 1 0 0 1 1 1 0 Hydantoinase/oxoprolinase OTCace_N PF02729.21 EDO19564.1 - 0.16 11.9 0.8 0.47 10.5 0.8 1.7 1 0 0 1 1 1 0 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain SWI-SNF_Ssr4 PF08549.10 EDO19564.1 - 0.65 8.6 7.5 0.83 8.2 0.1 2.1 2 0 0 2 2 2 0 Fungal domain of unknown function (DUF1750) Golgin_A5 PF09787.9 EDO19564.1 - 3.4 7.1 9.7 6.8 6.1 6.1 2.1 2 0 0 2 2 2 0 Golgin subfamily A member 5 tRNA-synt_1 PF00133.22 EDO19565.1 - 3.8e-244 811.5 0.6 4.1e-243 808.1 0.2 2.1 2 0 0 2 2 2 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 EDO19565.1 - 1.2e-25 90.2 0.1 3.8e-25 88.6 0.0 1.9 2 0 0 2 2 2 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 EDO19565.1 - 6.3e-17 61.4 0.4 8.7e-06 24.7 0.2 3.7 3 1 0 3 3 3 3 tRNA synthetases class I (M) tRNA-synt_1e PF01406.19 EDO19565.1 - 0.0002 20.8 0.0 0.00061 19.2 0.0 1.8 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain Atg8 PF02991.16 EDO19567.1 - 1.2e-50 170.0 0.1 1.3e-50 169.9 0.1 1.0 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like APG12 PF04110.13 EDO19567.1 - 1.4e-06 28.6 0.0 1.9e-06 28.2 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 MAM1 PF10434.9 EDO19568.1 - 9.7e-102 340.1 13.7 1.3e-101 339.8 13.7 1.1 1 0 0 1 1 1 1 Monopolin complex protein MAM1 DUF5349 PF17298.2 EDO19569.1 - 4.2e-37 128.8 116.0 3.7e-22 79.6 94.2 2.2 1 1 1 2 2 2 2 Family of unknown function (DUF5349) WD40 PF00400.32 EDO19570.1 - 6.1e-19 68.0 11.0 5.6e-05 23.8 0.8 5.6 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDO19570.1 - 1.1e-08 35.3 0.2 0.0083 16.4 0.0 4.8 3 2 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EDO19570.1 - 0.00021 20.1 0.2 0.31 9.6 0.0 2.3 2 0 0 2 2 2 2 Nucleoporin Nup120/160 eIF2A PF08662.11 EDO19570.1 - 0.0012 18.8 0.1 2 8.3 0.0 3.7 2 1 1 4 4 4 2 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 EDO19570.1 - 0.016 14.6 0.0 0.043 13.1 0.0 1.7 2 1 0 2 2 2 0 WD40-like domain BBS1 PF14779.6 EDO19570.1 - 0.17 11.3 0.0 0.27 10.7 0.0 1.2 1 0 0 1 1 1 0 Ciliary BBSome complex subunit 1 HEAT_EZ PF13513.6 EDO19571.1 - 2.6e-17 62.9 0.2 0.0054 17.2 0.0 8.6 8 0 0 8 8 8 2 HEAT-like repeat IBN_N PF03810.19 EDO19571.1 - 2.1e-14 53.2 8.6 1.5e-12 47.2 0.4 5.3 4 1 1 5 5 5 1 Importin-beta N-terminal domain HEAT PF02985.22 EDO19571.1 - 3.7e-09 36.1 4.4 0.24 11.8 0.0 7.8 10 0 0 10 10 9 2 HEAT repeat HEAT_2 PF13646.6 EDO19571.1 - 2e-08 34.5 0.9 11 6.6 0.0 7.0 7 2 2 9 9 8 2 HEAT repeats CLASP_N PF12348.8 EDO19571.1 - 1.6e-05 24.6 1.5 1.9 8.0 0.0 5.9 6 1 1 7 7 7 1 CLASP N terminal Cnd1 PF12717.7 EDO19571.1 - 0.00013 22.0 6.6 0.69 9.9 0.1 5.4 5 0 0 5 5 5 1 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 EDO19571.1 - 0.00031 21.3 6.7 16 6.2 0.0 7.2 6 2 4 10 10 10 0 Vacuolar 14 Fab1-binding region RIX1 PF08167.12 EDO19571.1 - 0.0014 18.4 3.2 0.27 10.9 0.0 4.8 6 0 0 6 6 6 1 rRNA processing/ribosome biogenesis PAD_M PF08527.10 EDO19571.1 - 0.014 15.1 0.2 0.048 13.3 0.1 1.9 2 0 0 2 2 2 0 Protein-arginine deiminase (PAD) middle domain G-alpha PF00503.20 EDO19571.1 - 0.02 14.1 0.6 0.05 12.8 0.1 2.0 2 0 0 2 2 2 0 G-protein alpha subunit DUF2950 PF11453.8 EDO19571.1 - 0.027 13.7 0.0 0.065 12.4 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2950) Arm PF00514.23 EDO19571.1 - 0.12 12.4 4.7 7.8 6.7 0.0 5.0 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat Xpo1 PF08389.12 EDO19571.1 - 0.14 12.2 10.3 1.3 9.1 0.2 5.4 6 1 0 6 6 6 0 Exportin 1-like protein DUF3385 PF11865.8 EDO19571.1 - 0.95 9.4 12.6 7.2 6.5 0.0 6.5 5 3 2 7 7 7 0 Domain of unknown function (DUF3385) Ank_2 PF12796.7 EDO19572.1 - 2.7e-09 37.5 0.9 0.0056 17.2 0.0 3.1 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EDO19572.1 - 2.8e-07 30.9 1.7 3.4e-05 24.3 0.1 3.1 2 1 0 2 2 2 1 Ankyrin repeats (many copies) KilA-N PF04383.13 EDO19572.1 - 8.4e-07 28.8 0.9 8.4e-07 28.8 0.9 4.3 4 2 0 4 4 4 1 KilA-N domain Ank_5 PF13857.6 EDO19572.1 - 5.8e-06 26.5 1.3 0.026 14.9 0.2 3.0 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EDO19572.1 - 7.6e-06 25.9 3.1 0.014 15.9 0.1 3.8 3 0 0 3 3 3 2 Ankyrin repeat Ank PF00023.30 EDO19572.1 - 0.00026 21.3 11.5 0.056 13.9 0.3 3.8 5 0 0 5 5 5 2 Ankyrin repeat TPR_2 PF07719.17 EDO19573.1 - 2.7e-39 130.1 10.7 3.8e-08 32.8 0.1 8.8 9 0 0 9 9 9 6 Tetratricopeptide repeat TPR_1 PF00515.28 EDO19573.1 - 2.7e-33 112.4 16.9 4.2e-09 35.9 0.3 8.4 9 0 0 9 9 8 6 Tetratricopeptide repeat TPR_8 PF13181.6 EDO19573.1 - 4e-29 98.4 13.8 0.00023 21.2 0.2 8.5 9 0 0 9 9 8 6 Tetratricopeptide repeat ANAPC3 PF12895.7 EDO19573.1 - 1.5e-28 98.8 25.6 4.4e-16 58.9 1.0 4.6 4 0 0 4 4 4 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.6 EDO19573.1 - 4e-24 84.0 11.0 0.00016 21.3 0.1 7.5 4 2 3 7 7 7 5 TPR repeat TPR_14 PF13428.6 EDO19573.1 - 1.1e-20 72.6 0.1 0.00058 20.5 0.1 6.9 3 2 3 6 6 6 4 Tetratricopeptide repeat TPR_16 PF13432.6 EDO19573.1 - 5e-20 71.9 0.2 1.3e-07 32.1 0.0 4.6 4 1 1 5 5 4 2 Tetratricopeptide repeat TPR_12 PF13424.6 EDO19573.1 - 7.9e-16 58.1 9.9 0.0002 21.6 0.1 6.5 5 2 3 8 8 7 4 Tetratricopeptide repeat TPR_17 PF13431.6 EDO19573.1 - 2.2e-15 55.8 24.8 1.9e-05 24.7 0.6 8.5 9 0 0 9 9 8 4 Tetratricopeptide repeat TPR_19 PF14559.6 EDO19573.1 - 5e-15 55.8 1.9 0.00048 20.6 0.0 4.6 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_7 PF13176.6 EDO19573.1 - 4.9e-11 41.8 2.9 0.72 10.0 0.1 7.0 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_9 PF13371.6 EDO19573.1 - 6.4e-11 42.2 0.0 3e-06 27.3 0.1 3.9 2 2 2 4 4 4 3 Tetratricopeptide repeat TPR_6 PF13174.6 EDO19573.1 - 5.9e-09 36.0 8.5 0.05 14.3 0.0 7.1 9 0 0 9 9 7 2 Tetratricopeptide repeat TPR_15 PF13429.6 EDO19573.1 - 2e-06 27.2 0.0 0.03 13.5 0.0 3.5 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 EDO19573.1 - 7.1e-05 22.6 6.8 2.3 8.2 0.1 5.9 6 0 0 6 6 6 1 Tetratricopeptide repeat DUF3856 PF12968.7 EDO19573.1 - 0.0065 16.5 0.4 15 5.6 0.1 4.2 2 1 2 4 4 4 0 Domain of Unknown Function (DUF3856) TPR_20 PF14561.6 EDO19573.1 - 0.062 13.6 0.1 36 4.8 0.0 3.3 3 1 0 3 3 2 0 Tetratricopeptide repeat SRP_TPR_like PF17004.5 EDO19573.1 - 0.078 13.0 6.7 0.063 13.3 0.6 3.5 2 2 0 2 2 2 0 Putative TPR-like repeat HrpB1_HrpK PF09613.10 EDO19573.1 - 0.085 12.5 0.0 26 4.5 0.0 3.1 2 1 1 3 3 3 0 Bacterial type III secretion protein (HrpB1_HrpK) TPR_MalT PF17874.1 EDO19573.1 - 0.1 12.0 0.2 0.81 9.0 0.2 2.2 1 1 0 1 1 1 0 MalT-like TPR region BTAD PF03704.17 EDO19573.1 - 0.13 12.7 0.5 10 6.6 0.0 2.7 1 1 1 2 2 2 0 Bacterial transcriptional activator domain TPR_3 PF07720.12 EDO19573.1 - 0.26 11.3 17.0 3.8 7.6 0.1 5.3 5 0 0 5 5 5 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EDO19573.1 - 1.3 9.2 13.2 18 5.5 0.1 5.8 6 1 1 7 7 6 0 Fis1 C-terminal tetratricopeptide repeat PH PF00169.29 EDO19574.1 - 1.1e-19 70.9 0.0 5.3e-19 68.7 0.0 2.2 2 0 0 2 2 2 1 PH domain SAM_2 PF07647.17 EDO19574.1 - 6e-12 45.5 0.1 1.1e-11 44.7 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SH3_1 PF00018.28 EDO19574.1 - 8.9e-12 44.4 0.2 2.2e-11 43.2 0.2 1.7 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EDO19574.1 - 2.9e-09 36.6 0.2 5.5e-09 35.7 0.2 1.5 1 0 0 1 1 1 1 Variant SH3 domain SAM_1 PF00536.30 EDO19574.1 - 0.00076 19.9 0.0 0.0014 19.0 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PH_8 PF15409.6 EDO19574.1 - 0.0021 18.3 0.0 0.069 13.4 0.0 2.6 2 0 0 2 2 2 1 Pleckstrin homology domain SH3_2 PF07653.17 EDO19574.1 - 0.0072 16.0 0.1 0.015 14.9 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain PH_11 PF15413.6 EDO19574.1 - 0.013 16.0 0.1 0.013 16.0 0.1 4.1 3 1 0 3 3 3 0 Pleckstrin homology domain NT-C2 PF10358.9 EDO19575.1 - 5.8e-47 159.1 0.0 8.6e-47 158.5 0.0 1.3 1 0 0 1 1 1 1 N-terminal C2 in EEIG1 and EHBP1 proteins Motile_Sperm PF00635.26 EDO19576.1 - 6e-26 90.4 0.3 1.5e-25 89.2 0.0 1.8 2 0 0 2 2 2 1 MSP (Major sperm protein) domain TMEM131_like PF12371.8 EDO19576.1 - 0.0012 19.1 0.2 0.0022 18.2 0.2 1.4 1 0 0 1 1 1 1 Transmembrane protein 131-like PapD-like PF14874.6 EDO19576.1 - 0.033 14.3 0.1 0.064 13.4 0.1 1.4 1 0 0 1 1 1 0 Flagellar-associated PapD-like PhnG PF06754.12 EDO19576.1 - 0.091 12.7 0.2 0.23 11.4 0.0 1.7 2 0 0 2 2 2 0 Phosphonate metabolism protein PhnG Ribosomal_L32e PF01655.18 EDO19577.1 - 2.4e-46 156.6 1.7 2.8e-46 156.4 1.7 1.0 1 0 0 1 1 1 1 Ribosomal protein L32 ArfGap PF01412.18 EDO19578.1 - 8.4e-34 116.2 0.3 8.4e-34 116.2 0.3 2.5 3 0 0 3 3 3 1 Putative GTPase activating protein for Arf Flu_B_M2 PF04772.12 EDO19578.1 - 0.18 12.0 0.0 0.47 10.7 0.0 1.6 1 1 0 1 1 1 0 Influenza B matrix protein 2 (BM2) 4HBT PF03061.22 EDO19579.1 - 2.9e-06 27.5 0.0 5.9e-06 26.6 0.0 1.5 1 0 0 1 1 1 1 Thioesterase superfamily AAA PF00004.29 EDO19580.1 - 1e-17 64.8 0.1 3e-17 63.3 0.0 1.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EDO19580.1 - 2.8e-05 24.6 0.3 0.00022 21.7 0.0 2.2 2 0 0 2 2 2 1 AAA ATPase domain TIP49 PF06068.13 EDO19580.1 - 0.00026 20.3 0.0 0.00039 19.8 0.0 1.2 1 0 0 1 1 1 1 TIP49 P-loop domain RuvB_N PF05496.12 EDO19580.1 - 0.0035 17.1 0.0 0.0062 16.3 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 EDO19580.1 - 0.0074 16.3 0.0 0.014 15.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.17 EDO19580.1 - 0.015 15.0 0.1 0.031 14.0 0.1 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_22 PF13401.6 EDO19580.1 - 0.021 15.1 0.5 0.06 13.6 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 EDO19580.1 - 0.023 14.9 0.1 0.17 12.1 0.0 2.2 2 0 0 2 2 2 0 AAA domain Mg_chelatase PF01078.21 EDO19580.1 - 0.032 13.6 0.2 0.058 12.8 0.2 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI TsaE PF02367.17 EDO19580.1 - 0.039 13.9 0.0 0.093 12.7 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_18 PF13238.6 EDO19580.1 - 0.043 14.4 0.3 0.17 12.4 0.0 2.1 2 0 0 2 2 2 0 AAA domain PhoH PF02562.16 EDO19580.1 - 0.11 11.9 0.2 0.22 10.9 0.2 1.4 1 0 0 1 1 1 0 PhoH-like protein ATPase PF06745.13 EDO19580.1 - 0.14 11.4 0.0 0.25 10.6 0.0 1.4 1 0 0 1 1 1 0 KaiC Sigma54_activat PF00158.26 EDO19580.1 - 0.17 11.6 0.1 0.46 10.2 0.0 1.7 2 0 0 2 2 2 0 Sigma-54 interaction domain Bud13 PF09736.9 EDO19580.1 - 0.34 11.3 2.8 0.52 10.7 2.8 1.2 1 0 0 1 1 1 0 Pre-mRNA-splicing factor of RES complex Peptidase_M41 PF01434.18 EDO19581.1 - 1.1e-61 208.1 0.8 1.8e-61 207.4 0.8 1.4 1 0 0 1 1 1 1 Peptidase family M41 AAA_lid_3 PF17862.1 EDO19581.1 - 2.5e-07 30.4 0.1 1e-06 28.5 0.0 2.1 2 0 0 2 2 2 1 AAA+ lid domain ATP-synt_ab PF00006.25 EDO19582.1 - 8.7e-71 237.9 0.0 1.3e-70 237.4 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.27 EDO19582.1 - 6e-47 159.1 1.0 1e-46 158.3 1.0 1.4 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.23 EDO19582.1 - 3e-16 59.7 1.7 8e-16 58.3 1.7 1.7 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain Tex_N PF09371.10 EDO19582.1 - 0.082 12.6 0.1 0.23 11.1 0.0 1.7 2 0 0 2 2 2 0 Tex-like protein N-terminal domain Arrestin_C PF02752.22 EDO19583.1 - 2.3e-23 83.1 1.2 1.3e-22 80.7 0.2 2.5 2 0 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 EDO19583.1 - 1.4e-08 35.0 0.0 6.4e-07 29.5 0.0 2.7 1 1 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain LDB19 PF13002.7 EDO19583.1 - 0.00037 20.3 0.0 0.00076 19.2 0.0 1.5 1 0 0 1 1 1 1 Arrestin_N terminal like DAO PF01266.24 EDO19584.1 - 1.3e-21 77.6 0.0 1.6e-21 77.3 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase Trp_halogenase PF04820.14 EDO19584.1 - 0.0083 15.0 0.0 0.021 13.7 0.0 1.6 2 0 0 2 2 2 1 Tryptophan halogenase NitrOD1 PF18549.1 EDO19584.1 - 0.069 13.1 0.2 0.14 12.1 0.2 1.4 1 0 0 1 1 1 0 Nitrosopumilus output domain 1 Pyr_redox_2 PF07992.14 EDO19584.1 - 0.16 11.2 0.0 0.23 10.7 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Oxidored_FMN PF00724.20 EDO19585.1 - 6.3e-137 456.4 0.0 7.3e-137 456.2 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Cation_ATPase_N PF00690.26 EDO19585.1 - 0.17 11.6 0.1 0.76 9.5 0.0 2.1 2 0 0 2 2 2 0 Cation transporter/ATPase, N-terminus RRM_1 PF00076.22 EDO19586.1 - 3.2e-27 94.2 8.4 4.4e-10 39.2 0.0 4.5 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EDO19586.1 - 2e-06 27.4 1.9 0.024 14.3 0.2 2.9 2 1 1 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 EDO19586.1 - 0.014 15.4 0.3 0.22 11.6 0.0 3.0 4 0 0 4 4 4 0 RNA binding motif RNA_bind PF08675.11 EDO19586.1 - 0.045 13.8 0.0 11 6.1 0.0 3.2 3 0 0 3 3 3 0 RNA binding domain RRM_7 PF16367.5 EDO19586.1 - 0.065 13.4 0.1 39 4.5 0.0 4.0 4 1 0 4 4 4 0 RNA recognition motif Nup35_RRM_2 PF14605.6 EDO19586.1 - 0.15 12.0 0.1 0.54 10.3 0.1 1.9 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif DUF5474 PF17568.2 EDO19586.1 - 0.89 9.7 4.6 1.1 9.4 0.3 3.0 3 0 0 3 3 3 0 Family of unknown function (DUF5474) DUF1776 PF08643.10 EDO19587.1 - 2.3e-52 178.2 1.3 3.3e-52 177.7 1.3 1.1 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) Lyase_1 PF00206.20 EDO19588.1 - 7.1e-97 324.5 0.0 3.6e-96 322.2 0.0 1.9 2 0 0 2 2 2 1 Lyase ASL_C2 PF14698.6 EDO19588.1 - 1.9e-22 79.8 0.0 3.8e-22 78.8 0.0 1.5 1 0 0 1 1 1 1 Argininosuccinate lyase C-terminal BBE PF08031.12 EDO19588.1 - 0.35 11.0 1.9 34 4.6 0.0 3.1 3 0 0 3 3 3 0 Berberine and berberine like tRNA-synt_2 PF00152.20 EDO19589.1 - 9.7e-90 300.8 0.0 1.4e-89 300.3 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 EDO19589.1 - 6.5e-12 45.3 0.2 1.4e-11 44.2 0.2 1.6 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain PHP PF02811.19 EDO19590.1 - 1.7e-09 38.2 3.2 6.3e-09 36.3 3.2 1.9 1 1 0 1 1 1 1 PHP domain Enterotoxin_b PF01376.18 EDO19590.1 - 0.08 13.1 0.1 3.9 7.7 0.0 2.5 2 0 0 2 2 2 0 Heat-labile enterotoxin beta chain Fmp27_WPPW PF10359.9 EDO19591.1 - 8.5e-128 427.2 3.8 8.5e-128 427.2 3.8 1.9 2 0 0 2 2 2 1 RNA pol II promoter Fmp27 protein domain Apt1 PF10351.9 EDO19591.1 - 1.4e-96 324.3 14.4 6.4e-96 322.1 11.8 2.8 2 1 0 2 2 2 1 Golgi-body localisation protein domain Fmp27_GFWDK PF10347.9 EDO19591.1 - 1e-51 175.2 0.0 4.6e-51 173.0 0.0 2.3 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain DUF2405 PF10293.9 EDO19591.1 - 9e-44 149.1 3.0 4.7e-43 146.8 3.0 2.4 1 0 0 1 1 1 1 Domain of unknown function (DUF2405) Fmp27_SW PF10305.9 EDO19591.1 - 1.2e-18 67.7 0.2 8e-18 65.1 0.0 2.7 2 0 0 2 2 2 1 RNA pol II promoter Fmp27 protein domain RecJ_OB PF17768.1 EDO19591.1 - 0.048 13.9 0.1 0.16 12.2 0.1 1.9 1 0 0 1 1 1 0 RecJ OB domain RRG8 PF17068.5 EDO19593.1 - 2.8e-42 145.0 2.0 3.2e-42 144.8 2.0 1.0 1 0 0 1 1 1 1 Required for respiratory growth protein 8 mitochondrial PH PF00169.29 EDO19594.1 - 0.027 15.0 0.1 0.27 11.8 0.0 2.4 2 1 0 2 2 2 0 PH domain Mito_carr PF00153.27 EDO19595.1 - 7.4e-58 192.5 5.6 4.2e-18 65.1 0.0 3.1 2 1 1 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 EDO19595.1 - 0.0053 15.9 3.0 0.63 9.1 0.8 2.7 1 1 1 3 3 3 2 Gammaproteobacterial serine protease Tim17 PF02466.19 EDO19595.1 - 0.31 11.4 6.3 4.4 7.7 0.6 3.7 1 1 2 4 4 4 0 Tim17/Tim22/Tim23/Pmp24 family tRNA-synt_1 PF00133.22 EDO19596.1 - 2.4e-233 775.8 0.3 3.1e-232 772.1 0.3 2.2 1 1 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 EDO19596.1 - 4.9e-32 111.0 1.9 1.6e-31 109.4 1.9 1.9 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 EDO19596.1 - 1.1e-12 47.4 0.3 3.4e-06 26.1 0.0 4.1 3 1 0 3 3 3 3 tRNA synthetases class I (M) tRNA-synt_1_2 PF13603.6 EDO19596.1 - 9.5e-07 28.5 0.0 9.5e-07 28.5 0.0 3.4 3 1 1 4 4 3 2 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1e PF01406.19 EDO19596.1 - 0.00082 18.8 2.6 1.1 8.6 0.0 4.0 4 1 0 4 4 4 2 tRNA synthetases class I (C) catalytic domain Val_tRNA-synt_C PF10458.9 EDO19596.1 - 0.0016 18.6 8.2 0.0016 18.6 8.2 3.2 3 0 0 3 3 3 1 Valyl tRNA synthetase tRNA binding arm MICSWaP PF17018.5 EDO19596.1 - 0.15 11.6 4.3 0.29 10.7 4.3 1.4 1 0 0 1 1 1 0 Spore wall protein Borrelia_P83 PF05262.11 EDO19596.1 - 0.17 10.4 16.4 0.032 12.7 6.3 2.3 2 0 0 2 2 2 0 Borrelia P83/100 protein DUF3450 PF11932.8 EDO19596.1 - 0.55 9.5 8.5 9.2 5.5 4.6 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) Vfa1 PF08432.10 EDO19596.1 - 5.4 7.3 20.3 4.1 7.7 5.1 2.6 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 DASH_Spc19 PF08287.11 EDO19596.1 - 9.2 6.1 16.5 9.8 6.0 5.6 2.4 2 0 0 2 2 2 0 Spc19 RRM_1 PF00076.22 EDO19597.1 - 2e-69 229.4 11.0 1.2e-17 63.5 0.1 6.5 6 0 0 6 6 6 6 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EDO19597.1 - 7.5e-08 32.1 0.1 0.029 14.2 0.0 4.3 4 0 0 4 4 4 2 Occluded RNA-recognition motif RRM_5 PF13893.6 EDO19597.1 - 3e-07 30.1 0.0 0.00014 21.4 0.0 3.4 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EDO19597.1 - 0.00022 21.3 0.2 11 6.3 0.0 4.6 4 0 0 4 4 4 1 RNA recognition motif Nup35_RRM_2 PF14605.6 EDO19597.1 - 0.00062 19.7 0.0 10 6.2 0.0 4.5 5 0 0 5 5 5 1 Nup53/35/40-type RNA recognition motif SET_assoc PF11767.8 EDO19597.1 - 0.066 12.9 0.0 22 4.8 0.0 3.4 3 0 0 3 3 3 0 Histone lysine methyltransferase SET associated ClpS PF02617.17 EDO19597.1 - 0.11 12.3 0.1 0.34 10.7 0.1 1.8 1 0 0 1 1 1 0 ATP-dependent Clp protease adaptor protein ClpS DUF1699 PF08004.11 EDO19597.1 - 0.18 11.5 1.4 3.4 7.4 0.0 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF1699) CwfJ_C_1 PF04677.15 EDO19598.1 - 2.1e-33 114.8 2.2 3.4e-33 114.1 0.6 2.0 2 0 0 2 2 2 1 Protein similar to CwfJ C-terminus 1 CwfJ_C_2 PF04676.14 EDO19598.1 - 1e-13 52.0 2.7 1e-13 52.0 2.7 2.2 2 0 0 2 2 2 1 Protein similar to CwfJ C-terminus 2 PLA2_B PF01735.18 EDO19598.1 - 0.024 13.1 5.9 0.83 8.0 1.0 2.4 2 0 0 2 2 2 0 Lysophospholipase catalytic domain Pkinase PF00069.25 EDO19599.1 - 1.3e-55 188.6 0.0 5.4e-55 186.6 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO19599.1 - 7e-28 97.6 0.1 1.1e-19 70.7 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase_C PF00433.24 EDO19599.1 - 4.9e-06 27.1 3.6 0.0003 21.4 1.2 2.7 2 0 0 2 2 2 1 Protein kinase C terminal domain Haspin_kinase PF12330.8 EDO19599.1 - 0.0012 17.9 0.2 0.003 16.6 0.2 1.5 1 1 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 EDO19599.1 - 0.006 16.0 0.0 0.011 15.1 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EDO19599.1 - 0.012 14.9 0.0 0.052 12.9 0.0 2.0 2 0 0 2 2 2 0 Kinase-like APH PF01636.23 EDO19599.1 - 0.077 12.9 0.0 0.59 10.0 0.0 2.2 2 1 1 3 3 3 0 Phosphotransferase enzyme family Nop PF01798.18 EDO19600.1 - 5.9e-62 209.2 1.0 1.1e-61 208.2 1.0 1.5 1 0 0 1 1 1 1 snoRNA binding domain, fibrillarin Prp31_C PF09785.9 EDO19600.1 - 7.4e-27 94.7 3.4 1.4e-26 93.7 3.4 1.4 1 0 0 1 1 1 1 Prp31 C terminal domain FAM110_C PF14160.6 EDO19600.1 - 0.05 14.7 0.2 0.16 13.0 0.2 1.9 1 0 0 1 1 1 0 Centrosome-associated C terminus RNA_pol_A_bac PF01000.26 EDO19601.1 - 2e-30 105.4 0.0 4.1e-30 104.4 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 EDO19601.1 - 9e-21 73.1 0.0 1.6e-20 72.3 0.0 1.4 1 1 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Lipoprotein_20 PF13942.6 EDO19603.1 - 0.0059 16.6 1.2 0.0059 16.6 1.2 3.7 1 1 2 3 3 3 1 YfhG lipoprotein TEX12 PF15219.6 EDO19603.1 - 0.34 11.3 15.6 0.44 10.9 3.1 3.8 3 0 0 3 3 3 0 Testis-expressed 12 Sulfatase_C PF14707.6 EDO19603.1 - 3.1 8.6 6.5 5.5 7.7 1.3 2.6 2 0 0 2 2 2 0 C-terminal region of aryl-sulfatase DUF3095 PF11294.8 EDO19603.1 - 5.6 5.9 7.5 11 5.0 7.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3095) zf-CCCH PF00642.24 EDO19604.1 - 6.9e-17 60.9 24.5 0.001 18.9 0.4 5.4 5 0 0 5 5 5 5 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 EDO19604.1 - 5e-15 55.0 29.6 3.2e-06 27.0 2.9 5.4 5 0 0 5 5 5 5 Zinc finger domain Torus PF16131.5 EDO19604.1 - 8.5e-11 42.5 23.0 0.002 18.8 0.4 5.2 1 1 4 5 5 5 4 Torus domain zf-CCCH_3 PF15663.5 EDO19604.1 - 2.5e-05 24.5 6.3 2.5e-05 24.5 6.3 2.4 1 1 1 2 2 2 2 Zinc-finger containing family zf-CCCH_4 PF18044.1 EDO19604.1 - 0.00012 21.7 25.1 0.00047 19.9 0.5 4.6 5 0 0 5 5 5 3 CCCH-type zinc finger DUF4905 PF16248.5 EDO19604.1 - 0.12 12.3 0.0 0.21 11.5 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4905) Nab2p_Zf1 PF18260.1 EDO19604.1 - 0.13 12.2 0.2 0.13 12.2 0.2 4.1 4 0 0 4 4 4 0 Nuclear polyadenylated RNA-binding 2 protein CCCH zinc finger 1 Forkhead PF00250.18 EDO19605.1 - 3.6e-25 88.0 0.1 1e-24 86.5 0.1 1.9 1 0 0 1 1 1 1 Forkhead domain FHA PF00498.26 EDO19605.1 - 2.3e-12 47.1 0.5 7.1e-12 45.5 0.5 1.9 1 0 0 1 1 1 1 FHA domain Proteasome PF00227.26 EDO19606.1 - 3.7e-47 160.3 0.1 4.5e-47 160.0 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit DUF4359 PF14271.6 EDO19607.1 - 0.035 14.9 0.1 0.046 14.5 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4359) Sdh_cyt PF01127.22 EDO19609.1 - 1.5e-20 73.5 3.2 1.9e-20 73.1 3.2 1.1 1 0 0 1 1 1 1 Succinate dehydrogenase/Fumarate reductase transmembrane subunit Pkinase PF00069.25 EDO19610.1 - 1e-72 244.7 0.0 1.6e-72 244.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO19610.1 - 3.7e-33 114.9 0.0 6.2e-33 114.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EDO19610.1 - 3e-07 29.7 0.1 9.2e-07 28.1 0.1 1.7 1 1 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 EDO19610.1 - 6.3e-06 25.7 0.0 2.8e-05 23.6 0.0 1.9 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 EDO19610.1 - 0.0053 16.1 0.4 0.055 12.8 0.4 2.2 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.11 EDO19610.1 - 0.045 12.8 0.2 0.082 12.0 0.2 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 Pkinase_fungal PF17667.1 EDO19610.1 - 0.053 12.3 2.6 0.09 11.5 0.0 2.0 2 0 0 2 2 2 0 Fungal protein kinase APH PF01636.23 EDO19610.1 - 0.098 12.6 0.9 0.25 11.2 0.2 1.9 2 0 0 2 2 2 0 Phosphotransferase enzyme family Imm64 PF15600.6 EDO19610.1 - 0.14 11.8 0.1 0.28 10.9 0.1 1.4 1 0 0 1 1 1 0 Immunity protein 64 Spt20 PF12090.8 EDO19610.1 - 0.17 11.4 11.7 0.35 10.5 11.7 1.5 1 0 0 1 1 1 0 Spt20 family DASH_Hsk3 PF08227.11 EDO19611.1 - 6e-19 68.1 3.5 7.8e-19 67.8 3.5 1.2 1 0 0 1 1 1 1 DASH complex subunit Hsk3 like Spc24 PF08286.11 EDO19612.1 - 3e-22 78.9 1.4 2.5e-21 75.9 0.0 2.4 1 1 1 2 2 2 1 Spc24 subunit of Ndc80 DUF1664 PF07889.12 EDO19612.1 - 0.24 11.5 4.0 2 8.4 0.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Adaptin_N PF01602.20 EDO19613.1 - 8e-127 424.0 19.6 1e-126 423.6 19.6 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 EDO19613.1 - 9.9e-55 185.0 6.3 9.9e-55 185.0 6.3 3.5 4 1 0 4 4 4 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EDO19613.1 - 3.6e-12 46.5 0.1 3.2e-06 27.5 0.0 5.4 4 1 1 6 6 6 2 HEAT repeats HEAT PF02985.22 EDO19613.1 - 3.7e-09 36.1 2.1 0.026 14.8 0.0 5.2 5 0 0 5 5 5 3 HEAT repeat Arm PF00514.23 EDO19613.1 - 0.00021 21.2 1.4 0.0024 17.9 0.4 3.4 3 0 0 3 3 3 1 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 EDO19613.1 - 0.00098 19.6 0.1 1.3 9.6 0.0 3.5 3 0 0 3 3 3 1 HEAT-like repeat RTP1_C1 PF10363.9 EDO19613.1 - 0.033 14.4 7.9 1.3 9.2 0.1 5.1 2 2 3 5 5 5 0 Required for nuclear transport of RNA pol II C-terminus 1 Ssl1 PF04056.14 EDO19613.1 - 0.035 13.9 1.3 1.2 8.9 0.0 2.9 3 0 0 3 3 3 0 Ssl1-like Atx10homo_assoc PF09759.9 EDO19613.1 - 0.43 10.6 0.0 0.43 10.6 0.0 3.4 3 1 1 4 4 4 0 Spinocerebellar ataxia type 10 protein domain TPR_12 PF13424.6 EDO19614.1 - 0.014 15.7 0.9 8.4 6.8 0.1 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat SRAP PF02586.14 EDO19615.1 - 5e-69 232.2 0.2 6.1e-69 231.9 0.2 1.1 1 0 0 1 1 1 1 SOS response associated peptidase (SRAP) Toxin_8 PF07365.12 EDO19615.1 - 0.074 13.2 0.1 0.14 12.3 0.1 1.4 1 0 0 1 1 1 0 Alpha conotoxin precursor Dynamin_N PF00350.23 EDO19615.1 - 0.082 13.0 0.4 0.14 12.2 0.4 1.5 1 0 0 1 1 1 0 Dynamin family Med11 PF10280.9 EDO19616.1 - 8e-13 49.0 1.4 9.8e-13 48.7 1.4 1.3 1 1 0 1 1 1 1 Mediator complex protein ING PF12998.7 EDO19616.1 - 0.00091 19.8 1.3 0.0017 18.9 1.3 1.7 1 1 0 1 1 1 1 Inhibitor of growth proteins N-terminal histone-binding RPW8 PF05659.11 EDO19616.1 - 0.0057 16.3 1.3 0.0096 15.6 0.3 1.7 1 1 1 2 2 2 1 Arabidopsis broad-spectrum mildew resistance protein RPW8 Tup_N PF08581.10 EDO19616.1 - 0.0076 16.5 1.6 0.0076 16.5 0.4 1.6 2 0 0 2 2 2 1 Tup N-terminal CM_2 PF01817.21 EDO19616.1 - 0.012 16.0 0.0 0.058 13.7 0.0 1.9 1 1 0 2 2 2 0 Chorismate mutase type II Med29 PF11568.8 EDO19616.1 - 0.029 14.6 0.1 0.038 14.2 0.1 1.4 1 0 0 1 1 1 0 Mediator complex subunit 29 She2p PF11435.8 EDO19617.1 - 1.5e-86 289.3 14.7 1.9e-86 288.9 14.7 1.1 1 0 0 1 1 1 1 RNA binding protein She2p Myosin_head PF00063.21 EDO19618.1 - 1.9e-234 779.9 11.5 2.4e-234 779.6 11.5 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_TH1 PF06017.13 EDO19618.1 - 5.2e-49 166.5 2.9 1e-48 165.5 2.9 1.6 1 0 0 1 1 1 1 Unconventional myosin tail, actin- and lipid-binding SH3_1 PF00018.28 EDO19618.1 - 1.5e-11 43.7 0.0 2.9e-11 42.8 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EDO19618.1 - 1.5e-08 34.4 0.1 3.3e-08 33.2 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EDO19618.1 - 1.2e-07 31.2 0.0 3.2e-07 29.9 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain AAA_22 PF13401.6 EDO19618.1 - 0.033 14.5 0.0 0.13 12.6 0.0 2.0 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EDO19618.1 - 0.043 14.2 0.0 0.16 12.3 0.0 2.0 2 0 0 2 2 1 0 AAA ATPase domain NACHT PF05729.12 EDO19618.1 - 0.061 13.2 0.0 0.18 11.7 0.0 1.8 2 0 0 2 2 2 0 NACHT domain Sigma54_activat PF00158.26 EDO19618.1 - 0.062 13.0 0.0 0.14 11.8 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain RsgA_GTPase PF03193.16 EDO19618.1 - 0.071 13.0 0.1 0.16 11.9 0.1 1.5 1 0 0 1 1 1 0 RsgA GTPase RNA_helicase PF00910.22 EDO19618.1 - 0.091 13.2 0.0 0.4 11.1 0.0 2.2 1 0 0 1 1 1 0 RNA helicase Hpr_kinase_C PF07475.12 EDO19618.1 - 0.12 11.9 0.1 8.8 5.8 0.0 2.6 2 0 0 2 2 2 0 HPr Serine kinase C-terminal domain IQ PF00612.27 EDO19618.1 - 4.1 7.5 14.4 2.2 8.3 6.2 2.6 1 1 1 2 2 2 0 IQ calmodulin-binding motif His_Phos_1 PF00300.22 EDO19619.1 - 2.8e-08 33.7 0.0 6.1e-06 26.1 0.0 2.7 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) MraZ PF02381.18 EDO19619.1 - 0.089 12.8 0.2 1 9.4 0.0 2.2 2 0 0 2 2 2 0 MraZ protein, putative antitoxin-like Ku PF02735.16 EDO19620.1 - 1.2e-31 110.0 0.5 2e-31 109.3 0.5 1.3 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain Ku_N PF03731.15 EDO19620.1 - 1.9e-19 70.3 0.3 3.5e-19 69.4 0.3 1.5 1 0 0 1 1 1 1 Ku70/Ku80 N-terminal alpha/beta domain Psb28 PF03912.14 EDO19620.1 - 0.089 13.1 0.1 0.26 11.6 0.1 1.8 1 0 0 1 1 1 0 Psb28 protein PGM_PMM_I PF02878.16 EDO19621.1 - 1.1e-34 119.1 0.1 1.8e-34 118.4 0.1 1.4 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_III PF02880.16 EDO19621.1 - 1.7e-26 92.6 0.0 3.1e-26 91.8 0.0 1.4 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.16 EDO19621.1 - 1.9e-12 47.7 0.0 3.8e-12 46.7 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.20 EDO19621.1 - 2.7e-05 24.2 0.0 6.5e-05 23.0 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain Pkinase PF00069.25 EDO19622.1 - 7e-69 232.1 0.0 1e-68 231.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDO19622.1 - 7.4e-32 110.6 0.0 1.2e-31 110.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.24 EDO19622.1 - 3.5e-10 40.4 0.7 1.1e-09 38.9 0.7 1.9 1 0 0 1 1 1 1 Protein kinase C terminal domain Haspin_kinase PF12330.8 EDO19622.1 - 2.9e-06 26.5 0.1 4.3e-06 25.9 0.1 1.2 1 0 0 1 1 1 1 Haspin like kinase domain FTA2 PF13095.6 EDO19622.1 - 0.05 13.2 0.1 3.1 7.4 0.0 2.2 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 EDO19622.1 - 0.092 12.1 0.2 0.16 11.3 0.2 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EDO19622.1 - 0.14 11.5 0.0 0.3 10.3 0.0 1.6 2 0 0 2 2 2 0 Kinase-like SPRY PF00622.28 EDO19623.1 - 2.1e-12 47.2 0.0 4.7e-12 46.1 0.0 1.6 1 0 0 1 1 1 1 SPRY domain WD40 PF00400.32 EDO19624.1 - 1.7e-14 54.0 18.4 6.9e-05 23.5 0.1 6.8 7 1 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDO19624.1 - 0.0001 22.5 0.2 1.4 9.3 0.0 4.1 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EDO19624.1 - 0.0013 17.8 0.0 0.0026 16.8 0.0 1.5 1 0 0 1 1 1 1 WD40 region of Ge1, enhancer of mRNA-decapping protein zf-RRN7 PF11781.8 EDO19624.1 - 6.4 6.6 7.0 39 4.0 7.0 2.2 1 1 0 1 1 1 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 Mito_carr PF00153.27 EDO19625.1 - 3.9e-57 190.2 3.3 3.6e-21 74.9 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Vma12 PF11712.8 EDO19626.1 - 5.8e-38 130.1 0.9 8.1e-38 129.6 0.9 1.2 1 0 0 1 1 1 1 Endoplasmic reticulum-based factor for assembly of V-ATPase MCR_C PF04609.12 EDO19626.1 - 0.0023 17.1 0.5 0.0039 16.3 0.5 1.3 1 0 0 1 1 1 1 Methyl-coenzyme M reductase operon protein C TMEM100 PF16311.5 EDO19626.1 - 0.15 11.7 0.5 0.26 10.9 0.5 1.4 1 0 0 1 1 1 0 Transmembrane protein 100 Hydrolase_3 PF08282.12 EDO19626.1 - 0.61 9.8 5.0 0.8 9.4 5.0 1.2 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase Renin_r PF07850.14 EDO19626.1 - 1.4 9.6 6.6 0.57 10.8 1.5 2.3 1 1 1 2 2 2 0 Renin receptor-like protein Aldose_epim PF01263.20 EDO19627.1 - 1e-41 143.2 0.3 1.2e-41 143.0 0.3 1.0 1 0 0 1 1 1 1 Aldose 1-epimerase Glyco_hydro_72 PF03198.14 EDO19628.1 - 8.9e-146 485.1 6.9 1.2e-145 484.7 6.9 1.1 1 0 0 1 1 1 1 Glucanosyltransferase Cellulase PF00150.18 EDO19628.1 - 0.00043 19.8 0.3 0.0025 17.3 0.3 2.1 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_2_C PF02836.17 EDO19628.1 - 0.0013 17.9 0.1 0.0024 17.0 0.1 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Coilin_N PF15862.5 EDO19628.1 - 0.012 15.4 0.3 0.025 14.4 0.3 1.5 1 1 0 1 1 1 0 Coilin N-terminus SPX PF03105.19 EDO19628.1 - 0.1 12.5 16.5 0.15 12.0 16.5 1.2 1 0 0 1 1 1 0 SPX domain Nop14 PF04147.12 EDO19628.1 - 0.15 10.3 2.8 0.2 9.8 2.8 1.1 1 0 0 1 1 1 0 Nop14-like family Macoilin PF09726.9 EDO19628.1 - 0.22 10.0 20.3 0.29 9.6 20.3 1.1 1 0 0 1 1 1 0 Macoilin family GET2 PF08690.10 EDO19628.1 - 0.64 9.6 10.4 1.1 8.9 10.4 1.3 1 0 0 1 1 1 0 GET complex subunit GET2 BUD22 PF09073.10 EDO19628.1 - 0.78 9.0 15.7 1.1 8.5 15.7 1.2 1 0 0 1 1 1 0 BUD22 Sec3_C PF09763.9 EDO19628.1 - 0.79 8.0 6.2 1 7.7 6.2 1.1 1 0 0 1 1 1 0 Exocyst complex component Sec3 Apt1 PF10351.9 EDO19628.1 - 0.83 8.4 24.1 1.2 7.9 24.1 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Peroxin-3 PF04882.12 EDO19628.1 - 2.1 7.2 12.8 2.9 6.8 12.8 1.1 1 0 0 1 1 1 0 Peroxin-3 Tmemb_cc2 PF10267.9 EDO19628.1 - 2.6 7.1 9.1 3.6 6.6 9.1 1.2 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein SpoIIIAH PF12685.7 EDO19628.1 - 5.5 6.8 13.1 8.9 6.1 13.1 1.3 1 0 0 1 1 1 0 SpoIIIAH-like protein QWRF PF04484.12 EDO19628.1 - 6.2 6.5 18.0 9 5.9 18.0 1.2 1 0 0 1 1 1 0 QWRF family Presenilin PF01080.17 EDO19628.1 - 6.4 5.4 11.0 9.6 4.8 11.0 1.2 1 0 0 1 1 1 0 Presenilin HSD3 PF15244.6 EDO19628.1 - 7 6.0 18.6 11 5.5 18.6 1.2 1 0 0 1 1 1 0 Spermatogenesis-associated protein 7, or HSD3 ATP11 PF06644.11 EDO19628.1 - 9.1 6.0 7.1 14 5.4 7.1 1.2 1 0 0 1 1 1 0 ATP11 protein bZIP_1 PF00170.21 EDO19629.1 - 1.2e-05 25.3 4.3 1.2e-05 25.3 4.3 2.8 2 1 1 3 3 3 1 bZIP transcription factor bZIP_2 PF07716.15 EDO19629.1 - 0.0012 18.8 6.0 0.003 17.6 1.8 2.5 2 0 0 2 2 2 1 Basic region leucine zipper HAUS-augmin3 PF14932.6 EDO19629.1 - 0.053 13.1 5.5 0.091 12.3 5.5 1.3 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 Glutaredoxin2_C PF04399.13 EDO19629.1 - 0.056 13.3 1.0 0.12 12.2 1.0 1.5 1 0 0 1 1 1 0 Glutaredoxin 2, C terminal domain Uds1 PF15456.6 EDO19629.1 - 0.24 11.6 9.5 1.7 8.8 1.0 2.4 2 0 0 2 2 2 0 Up-regulated During Septation ZapB PF06005.12 EDO19629.1 - 0.33 11.4 7.8 0.94 10.0 7.8 1.8 1 1 0 1 1 1 0 Cell division protein ZapB DUF4094 PF13334.6 EDO19629.1 - 8.3 6.9 7.7 2.1 8.8 2.6 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4094) LETM1 PF07766.13 EDO19630.1 - 1.4e-99 332.8 4.9 1.4e-99 332.8 4.9 1.6 2 0 0 2 2 2 1 LETM1-like protein UCH PF00443.29 EDO19630.1 - 0.91 9.0 7.5 1.6 8.2 0.3 3.1 2 1 0 2 2 2 0 Ubiquitin carboxyl-terminal hydrolase ORC6 PF05460.13 EDO19630.1 - 1.9 7.7 14.7 3.6 6.8 14.7 1.4 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) DUF4047 PF13256.6 EDO19630.1 - 5.4 7.2 9.6 2.7 8.2 6.5 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4047) TOM13 PF08219.11 EDO19631.1 - 4.8e-24 84.1 0.1 5.1e-24 84.0 0.1 1.1 1 0 0 1 1 1 1 Outer membrane protein TOM13 DUF1635 PF07795.11 EDO19632.1 - 0.62 9.9 6.1 0.49 10.2 4.7 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1635) WBP-1 PF11669.8 EDO19632.1 - 0.83 10.3 3.8 1.9 9.1 0.2 2.5 1 1 1 2 2 2 0 WW domain-binding protein 1 Zip PF02535.22 EDO19632.1 - 2.9 7.0 7.7 6 6.0 7.7 1.5 1 1 0 1 1 1 0 ZIP Zinc transporter Macoilin PF09726.9 EDO19632.1 - 6.6 5.2 12.3 8.1 4.9 12.3 1.1 1 0 0 1 1 1 0 Macoilin family DUF5314 PF17241.2 EDO19635.1 - 7.9e-73 244.3 3.9 1.4e-72 243.5 3.9 1.4 1 0 0 1 1 1 1 Family of unknown function (DUF5314) rve PF00665.26 EDO19635.1 - 1.5e-15 57.5 0.0 3.3e-15 56.3 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain gag_pre-integrs PF13976.6 EDO19635.1 - 1.8e-15 56.6 0.0 6.9e-15 54.7 0.0 2.1 2 0 0 2 2 2 1 GAG-pre-integrase domain rve_3 PF13683.6 EDO19635.1 - 0.095 12.5 0.0 0.26 11.1 0.0 1.7 1 0 0 1 1 1 0 Integrase core domain FliG_C PF01706.16 EDO19635.1 - 0.11 12.6 0.1 0.79 9.9 0.1 2.1 2 0 0 2 2 2 0 FliG C-terminal domain Yae1_N PF09811.9 EDO19636.1 - 6.2e-14 51.4 0.0 2.1e-13 49.7 0.0 1.8 2 0 0 2 2 2 1 Essential protein Yae1, N terminal AAA PF00004.29 EDO19637.1 - 4.4e-16 59.5 0.1 1.5e-15 57.8 0.0 1.9 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Rep_fac_C PF08542.11 EDO19637.1 - 5.8e-15 55.5 0.0 1.7e-14 54.0 0.0 1.8 2 0 0 2 2 2 1 Replication factor C C-terminal domain DNA_pol3_delta2 PF13177.6 EDO19637.1 - 1.1e-12 48.1 0.0 2.2e-11 43.8 0.0 2.3 1 1 0 1 1 1 1 DNA polymerase III, delta subunit Rad17 PF03215.15 EDO19637.1 - 4.7e-09 36.4 0.0 1e-08 35.3 0.0 1.7 1 1 0 1 1 1 1 Rad17 P-loop domain AAA_assoc_2 PF16193.5 EDO19637.1 - 5.7e-06 26.6 0.1 1.5e-05 25.2 0.1 1.7 1 0 0 1 1 1 1 AAA C-terminal domain AAA_11 PF13086.6 EDO19637.1 - 6.2e-05 22.9 0.1 0.00014 21.7 0.1 1.8 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EDO19637.1 - 6.7e-05 23.2 0.1 0.001 19.4 0.1 2.5 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.12 EDO19637.1 - 8.8e-05 22.3 0.0 0.00024 20.9 0.0 1.7 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain Mg_chelatase PF01078.21 EDO19637.1 - 9.2e-05 21.9 0.0 0.0039 16.6 0.0 2.6 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI AAA_16 PF13191.6 EDO19637.1 - 0.00011 22.6 0.0 0.005 17.3 0.0 2.5 1 1 1 2 2 2 1 AAA ATPase domain TIP49_C PF17856.1 EDO19637.1 - 0.00016 21.7 0.4 0.00042 20.4 0.4 1.7 1 0 0 1 1 1 1 TIP49 AAA-lid domain ResIII PF04851.15 EDO19637.1 - 0.0017 18.4 0.1 0.028 14.4 0.0 2.6 2 2 1 3 3 3 1 Type III restriction enzyme, res subunit AAA_24 PF13479.6 EDO19637.1 - 0.0027 17.5 0.0 0.0077 16.0 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EDO19637.1 - 0.0054 17.1 0.0 0.028 14.7 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_23 PF13476.6 EDO19637.1 - 0.0099 16.4 0.1 0.023 15.2 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EDO19637.1 - 0.011 15.5 0.0 0.034 13.9 0.0 1.8 2 1 0 2 2 2 0 AAA domain DUF815 PF05673.13 EDO19637.1 - 0.011 14.9 0.0 0.02 14.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_7 PF12775.7 EDO19637.1 - 0.011 15.2 0.0 0.026 14.1 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region IFT20 PF14931.6 EDO19637.1 - 0.018 15.2 0.3 0.054 13.7 0.2 1.9 1 1 1 2 2 2 0 Intraflagellar transport complex B, subunit 20 DNA_pol3_delta PF06144.13 EDO19637.1 - 0.02 14.7 0.1 0.058 13.2 0.1 1.8 1 0 0 1 1 1 0 DNA polymerase III, delta subunit AAA_18 PF13238.6 EDO19637.1 - 0.022 15.3 0.8 0.37 11.3 0.0 2.7 1 1 1 2 2 2 0 AAA domain RNA_helicase PF00910.22 EDO19637.1 - 0.032 14.6 0.0 0.4 11.1 0.0 2.4 2 1 0 2 2 2 0 RNA helicase AAA_5 PF07728.14 EDO19637.1 - 0.042 13.8 0.2 0.34 10.9 0.2 2.2 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) DUF2075 PF09848.9 EDO19637.1 - 0.062 12.5 0.0 0.23 10.7 0.0 1.9 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) DEAD PF00270.29 EDO19637.1 - 0.11 12.3 0.2 1.4 8.7 0.0 2.6 1 1 2 3 3 3 0 DEAD/DEAH box helicase AAA_3 PF07726.11 EDO19637.1 - 0.13 12.2 0.0 1.1 9.1 0.0 2.2 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.6 EDO19637.1 - 0.13 12.5 0.0 0.23 11.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain Xpo1 PF08389.12 EDO19639.1 - 3.4e-37 127.8 6.8 3.6e-37 127.7 2.7 3.1 3 0 0 3 3 3 1 Exportin 1-like protein Ham1p_like PF01725.16 EDO19640.1 - 5.1e-53 179.8 0.1 5.7e-53 179.6 0.1 1.0 1 0 0 1 1 1 1 Ham1 family DUF1666 PF07891.12 EDO19640.1 - 0.11 12.2 0.6 0.26 10.9 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1666) PAC2 PF09754.9 EDO19641.1 - 2.2e-27 96.5 0.0 2.8e-27 96.1 0.0 1.1 1 0 0 1 1 1 1 PAC2 family ATP_bind_1 PF03029.17 EDO19642.1 - 1.6e-80 270.4 0.4 2.4e-80 269.8 0.4 1.2 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein GTP_EFTU PF00009.27 EDO19642.1 - 1.9e-08 34.1 0.3 4.3e-07 29.7 0.3 2.8 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_24 PF13479.6 EDO19642.1 - 7.2e-06 25.9 0.8 4.3e-05 23.3 0.0 2.2 2 1 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 EDO19642.1 - 9.8e-05 22.4 0.1 0.0037 17.3 0.0 2.7 2 1 0 2 2 2 1 50S ribosome-binding GTPase MeaB PF03308.16 EDO19642.1 - 0.00014 21.0 0.1 0.12 11.3 0.0 2.4 2 0 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB PduV-EutP PF10662.9 EDO19642.1 - 0.00036 20.3 0.2 0.012 15.3 0.0 2.5 2 1 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation SRP54 PF00448.22 EDO19642.1 - 0.00036 20.2 0.0 0.088 12.4 0.0 2.4 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain AAA_33 PF13671.6 EDO19642.1 - 0.0005 20.3 0.0 0.0012 19.0 0.0 1.6 1 1 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 EDO19642.1 - 0.00054 19.9 0.7 1.9 8.4 0.2 3.1 2 1 0 2 2 2 2 RsgA GTPase FeoB_N PF02421.18 EDO19642.1 - 0.0007 19.1 0.0 0.016 14.7 0.0 2.3 2 0 0 2 2 2 1 Ferrous iron transport protein B CLP1_P PF16575.5 EDO19642.1 - 0.00073 19.4 0.0 0.71 9.6 0.0 2.4 2 0 0 2 2 2 2 mRNA cleavage and polyadenylation factor CLP1 P-loop NACHT PF05729.12 EDO19642.1 - 0.0012 18.8 0.0 0.0024 17.8 0.0 1.5 1 0 0 1 1 1 1 NACHT domain AAA_18 PF13238.6 EDO19642.1 - 0.0013 19.3 0.3 0.0068 17.0 0.0 2.3 2 0 0 2 2 2 1 AAA domain cobW PF02492.19 EDO19642.1 - 0.0016 18.0 0.1 0.016 14.8 0.1 2.3 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain AAA_22 PF13401.6 EDO19642.1 - 0.0023 18.2 0.0 0.0097 16.2 0.0 2.1 3 0 0 3 3 2 1 AAA domain Roc PF08477.13 EDO19642.1 - 0.0055 16.9 0.1 0.7 10.1 0.0 2.8 2 1 1 3 3 3 1 Ras of Complex, Roc, domain of DAPkinase AAA_7 PF12775.7 EDO19642.1 - 0.0067 16.0 0.0 0.014 14.9 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_16 PF13191.6 EDO19642.1 - 0.0067 16.8 0.0 0.019 15.4 0.0 1.8 2 0 0 2 2 2 1 AAA ATPase domain AAA_30 PF13604.6 EDO19642.1 - 0.021 14.6 0.0 0.036 13.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.22 EDO19642.1 - 0.023 13.9 0.0 0.047 12.9 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain DUF87 PF01935.17 EDO19642.1 - 0.038 14.1 0.2 2.7 8.0 0.0 2.4 2 0 0 2 2 2 0 Helicase HerA, central domain AAA_31 PF13614.6 EDO19642.1 - 0.041 13.8 0.0 1.7 8.5 0.0 2.4 1 1 0 1 1 1 0 AAA domain Arf PF00025.21 EDO19642.1 - 0.047 13.1 0.0 3.4 7.1 0.0 2.6 2 1 0 2 2 2 0 ADP-ribosylation factor family SRPRB PF09439.10 EDO19642.1 - 0.061 12.7 4.7 0.42 10.0 0.0 2.8 3 0 0 3 3 3 0 Signal recognition particle receptor beta subunit NTPase_1 PF03266.15 EDO19642.1 - 0.071 13.0 0.1 0.52 10.2 0.1 2.1 1 1 0 1 1 1 0 NTPase MPM1 PF17234.2 EDO19642.1 - 0.083 13.1 2.1 0.12 12.6 2.1 1.3 1 0 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 Lipase_GDSL_3 PF14606.6 EDO19642.1 - 0.64 10.1 3.5 2 8.5 0.0 2.7 3 1 0 3 3 3 0 GDSL-like Lipase/Acylhydrolase family EMC3_TMCO1 PF01956.16 EDO19643.1 - 2.4e-56 190.1 1.0 3.6e-56 189.5 1.0 1.3 1 0 0 1 1 1 1 Integral membrane protein EMC3/TMCO1-like ABC_membrane PF00664.23 EDO19645.1 - 8.6e-98 327.3 28.7 5.9e-57 193.4 10.1 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EDO19645.1 - 2.5e-64 215.9 0.3 1.3e-33 116.4 0.0 2.6 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EDO19645.1 - 1.4e-11 44.3 7.6 0.0002 20.9 2.3 4.3 2 2 1 3 3 3 2 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 EDO19645.1 - 1.8e-09 37.7 0.1 0.0005 20.0 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase AAA_29 PF13555.6 EDO19645.1 - 3.8e-09 36.1 1.1 0.0018 18.0 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_22 PF13401.6 EDO19645.1 - 5.5e-08 33.2 2.5 0.0059 16.9 0.4 3.9 2 2 0 2 2 2 2 AAA domain Zeta_toxin PF06414.12 EDO19645.1 - 8.4e-08 31.7 0.1 0.007 15.7 0.0 3.2 3 0 0 3 3 3 2 Zeta toxin AAA_23 PF13476.6 EDO19645.1 - 3e-07 31.2 1.0 0.023 15.2 0.1 3.2 3 0 0 3 3 2 2 AAA domain AAA_16 PF13191.6 EDO19645.1 - 1.3e-06 28.9 0.0 0.088 13.2 0.0 3.0 2 0 0 2 2 2 2 AAA ATPase domain ABC_ATPase PF09818.9 EDO19645.1 - 1.9e-06 27.0 2.1 0.083 11.7 0.1 3.7 4 0 0 4 4 4 2 Predicted ATPase of the ABC class MMR_HSR1 PF01926.23 EDO19645.1 - 2e-06 27.8 0.4 0.069 13.2 0.0 3.0 2 1 0 2 2 2 2 50S ribosome-binding GTPase DUF87 PF01935.17 EDO19645.1 - 1.3e-05 25.5 0.4 0.03 14.4 0.0 3.1 3 0 0 3 3 2 2 Helicase HerA, central domain AAA_18 PF13238.6 EDO19645.1 - 1.9e-05 25.2 0.1 0.11 13.0 0.0 3.2 2 0 0 2 2 2 2 AAA domain AAA_15 PF13175.6 EDO19645.1 - 0.00018 21.4 12.6 0.0027 17.5 0.0 3.3 4 1 0 4 4 4 2 AAA ATPase domain AAA_30 PF13604.6 EDO19645.1 - 0.00028 20.7 0.2 0.81 9.4 0.1 3.3 2 1 0 2 2 2 1 AAA domain AAA_5 PF07728.14 EDO19645.1 - 0.00052 20.0 0.2 1.9 8.5 0.0 3.2 4 0 0 4 4 2 2 AAA domain (dynein-related subfamily) AAA_21 PF13304.6 EDO19645.1 - 0.00062 19.7 0.2 1.6 8.4 0.0 2.8 2 1 1 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_33 PF13671.6 EDO19645.1 - 0.00084 19.5 0.0 0.54 10.4 0.0 2.6 2 0 0 2 2 2 1 AAA domain DUF3987 PF13148.6 EDO19645.1 - 0.00086 18.4 0.0 0.28 10.2 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF3987) APS_kinase PF01583.20 EDO19645.1 - 0.00087 19.2 0.8 0.7 9.8 0.0 2.7 3 0 0 3 3 2 1 Adenylylsulphate kinase NB-ARC PF00931.22 EDO19645.1 - 0.00094 18.4 0.0 1.2 8.2 0.0 2.8 3 0 0 3 3 2 2 NB-ARC domain NACHT PF05729.12 EDO19645.1 - 0.00097 19.1 0.1 0.61 10.0 0.0 2.9 2 0 0 2 2 2 1 NACHT domain RNA_helicase PF00910.22 EDO19645.1 - 0.0012 19.2 0.0 3.6 8.0 0.0 2.8 2 0 0 2 2 2 2 RNA helicase Septin PF00735.18 EDO19645.1 - 0.0014 18.0 0.2 1.8 7.8 0.0 2.4 2 0 0 2 2 2 2 Septin ATP-synt_ab PF00006.25 EDO19645.1 - 0.0015 18.2 0.0 0.55 9.8 0.0 2.4 2 1 0 2 2 2 1 ATP synthase alpha/beta family, nucleotide-binding domain Ploopntkinase3 PF18751.1 EDO19645.1 - 0.0021 18.0 0.0 1.9 8.4 0.0 2.4 2 0 0 2 2 2 1 P-loop Nucleotide Kinase3 AAA_24 PF13479.6 EDO19645.1 - 0.0022 17.7 0.0 0.4 10.4 0.0 2.5 2 0 0 2 2 2 1 AAA domain DEAD PF00270.29 EDO19645.1 - 0.0028 17.4 4.8 0.71 9.6 0.0 4.0 3 2 0 3 3 3 1 DEAD/DEAH box helicase FtsK_SpoIIIE PF01580.18 EDO19645.1 - 0.0032 16.8 0.0 2.2 7.5 0.0 2.6 2 0 0 2 2 2 1 FtsK/SpoIIIE family AAA_13 PF13166.6 EDO19645.1 - 0.0053 15.5 0.1 0.027 13.1 0.1 2.1 2 0 0 2 2 2 1 AAA domain DUF815 PF05673.13 EDO19645.1 - 0.0067 15.6 0.4 3.3 6.8 0.0 2.7 3 0 0 3 3 2 1 Protein of unknown function (DUF815) ATPase PF06745.13 EDO19645.1 - 0.0077 15.6 2.1 1.9 7.8 0.1 3.0 3 0 0 3 3 3 1 KaiC AAA_7 PF12775.7 EDO19645.1 - 0.0092 15.5 0.0 4.1 6.9 0.0 2.6 2 0 0 2 2 2 0 P-loop containing dynein motor region G-alpha PF00503.20 EDO19645.1 - 0.0094 15.1 0.1 4.3 6.4 0.1 2.4 2 0 0 2 2 2 0 G-protein alpha subunit NTPase_1 PF03266.15 EDO19645.1 - 0.0098 15.8 0.1 5.5 6.9 0.0 3.4 3 0 0 3 3 3 0 NTPase Roc PF08477.13 EDO19645.1 - 0.013 15.7 0.3 7.6 6.8 0.0 3.6 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase T2SSE PF00437.20 EDO19645.1 - 0.013 14.5 0.0 3.9 6.5 0.0 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_14 PF13173.6 EDO19645.1 - 0.015 15.3 0.1 9.8 6.2 0.0 3.7 3 0 0 3 3 3 0 AAA domain Sigma54_activat PF00158.26 EDO19645.1 - 0.017 14.9 0.0 6.8 6.4 0.0 2.5 2 0 0 2 2 2 0 Sigma-54 interaction domain Pox_A32 PF04665.12 EDO19645.1 - 0.017 14.6 2.1 7.8 5.9 0.0 3.4 3 0 0 3 3 3 0 Poxvirus A32 protein AAA_25 PF13481.6 EDO19645.1 - 0.025 14.2 0.0 13 5.3 0.0 3.1 3 0 0 3 3 2 0 AAA domain cobW PF02492.19 EDO19645.1 - 0.039 13.5 0.8 7.3 6.1 0.1 3.2 3 0 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain Guanylate_kin PF00625.21 EDO19645.1 - 0.099 12.3 0.1 0.55 9.9 0.0 2.2 2 0 0 2 2 2 0 Guanylate kinase MobB PF03205.14 EDO19645.1 - 0.099 12.5 0.1 14 5.6 0.0 2.5 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B PRK PF00485.18 EDO19645.1 - 0.11 12.2 0.0 6 6.6 0.0 2.7 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family Gly_transf_sug PF04488.15 EDO19646.1 - 1.2e-13 51.5 0.0 4.6e-13 49.6 0.0 2.0 2 0 0 2 2 2 1 Glycosyltransferase sugar-binding region containing DXD motif DDE_Tnp_1_2 PF13586.6 EDO19646.1 - 0.036 14.4 0.5 0.073 13.5 0.5 1.4 1 0 0 1 1 1 0 Transposase DDE domain MgtE_N PF03448.17 EDO19646.1 - 0.091 13.4 0.1 0.23 12.1 0.1 1.7 1 0 0 1 1 1 0 MgtE intracellular N domain DUF1640 PF07798.11 EDO19646.1 - 4.5 7.3 10.0 0.37 10.8 4.5 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1640) Septin PF00735.18 EDO19647.1 - 3.4e-106 354.6 0.4 5.3e-106 354.0 0.0 1.5 2 0 0 2 2 2 1 Septin MMR_HSR1 PF01926.23 EDO19647.1 - 1.1e-06 28.8 0.0 2.6e-06 27.5 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase AIG1 PF04548.16 EDO19647.1 - 2.2e-05 23.9 0.0 5.1e-05 22.7 0.0 1.6 1 0 0 1 1 1 1 AIG1 family Dynamin_N PF00350.23 EDO19647.1 - 0.00017 21.7 5.3 0.0078 16.3 0.4 2.8 2 1 1 3 3 3 2 Dynamin family IIGP PF05049.13 EDO19647.1 - 0.0013 17.9 0.1 0.0025 17.0 0.1 1.4 1 0 0 1 1 1 1 Interferon-inducible GTPase (IIGP) RsgA_GTPase PF03193.16 EDO19647.1 - 0.003 17.5 7.2 0.0039 17.1 1.6 3.1 2 1 0 2 2 2 1 RsgA GTPase ABC_tran PF00005.27 EDO19647.1 - 0.039 14.5 0.1 0.11 13.0 0.0 1.8 2 0 0 2 2 2 0 ABC transporter IGPS PF00218.21 EDO19648.1 - 1.1e-88 296.7 0.1 1.4e-88 296.4 0.1 1.1 1 0 0 1 1 1 1 Indole-3-glycerol phosphate synthase GATase PF00117.28 EDO19648.1 - 3.5e-51 173.7 0.1 5.6e-51 173.0 0.1 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 EDO19648.1 - 1.9e-07 31.1 0.5 7.7e-07 29.1 0.5 1.9 1 1 0 1 1 1 1 Peptidase C26 QRPTase_C PF01729.19 EDO19648.1 - 0.00059 19.6 0.2 0.0035 17.1 0.1 2.3 3 0 0 3 3 3 1 Quinolinate phosphoribosyl transferase, C-terminal domain Peripla_BP_2 PF01497.18 EDO19648.1 - 0.0049 16.5 0.0 0.0096 15.5 0.0 1.4 1 0 0 1 1 1 1 Periplasmic binding protein Pneumovirus_M2 PF06436.11 EDO19648.1 - 0.0077 15.7 0.1 0.016 14.7 0.1 1.6 1 0 0 1 1 1 1 Pneumovirus matrix protein 2 (M2) BDM PF10684.9 EDO19648.1 - 0.13 12.6 0.1 0.37 11.2 0.1 1.7 1 0 0 1 1 1 0 Putative biofilm-dependent modulation protein FoP_duplication PF13865.6 EDO19649.1 - 3.3e-07 30.8 5.8 4.8e-07 30.2 5.8 1.3 1 0 0 1 1 1 1 C-terminal duplication domain of Friend of PRMT1 RRM_1 PF00076.22 EDO19649.1 - 0.0048 16.7 0.1 0.0079 16.0 0.1 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) OB_RNB PF08206.11 EDO19649.1 - 0.11 12.2 0.1 0.18 11.5 0.1 1.5 1 0 0 1 1 1 0 Ribonuclease B OB domain Mito_carr PF00153.27 EDO19650.1 - 1.1e-47 159.9 6.5 4e-18 65.1 0.2 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Flocculin PF00624.18 EDO19651.1 - 2.4e-122 399.0 345.3 2.6e-15 56.4 32.8 11.6 12 1 0 12 12 12 10 Flocculin repeat RnfC_N PF13375.6 EDO19651.1 - 0.14 12.1 8.6 1.2e+02 2.7 0.1 5.1 1 1 4 5 5 5 0 RnfC Barrel sandwich hybrid domain PBSX_XtrA PF17356.2 EDO19651.1 - 0.4 10.6 12.8 89 3.1 0.1 5.7 1 1 4 5 5 5 0 Phage-like element PBSX protein XtrA Flocculin PF00624.18 EDO19652.1 - 4.5e-17 62.0 61.2 3e-12 46.6 17.8 7.2 5 1 1 6 6 6 3 Flocculin repeat PilX_N PF14341.6 EDO19652.1 - 2.3 8.2 5.9 0.3 11.1 0.5 2.5 2 0 0 2 2 2 0 PilX N-terminal MFS_1 PF07690.16 EDO19653.1 - 1.4e-37 129.4 33.1 1.4e-37 129.4 33.1 1.7 1 1 1 2 2 2 1 Major Facilitator Superfamily OATP PF03137.20 EDO19653.1 - 3.4e-05 22.3 7.4 3.4e-05 22.3 7.4 2.4 1 1 1 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family TRI12 PF06609.13 EDO19653.1 - 0.00054 18.5 4.5 0.00088 17.8 4.5 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) # # Program: hmmscan # Version: 3.2.1 (June 2018) # Pipeline mode: SCAN # Query file: /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Vanderwaltozyma_polyspora_DSM70294-ASM15003v1/GCA_000150035.1_ASM15003v1_protein.faa # Target file: /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm # Option settings: /oak/stanford/groups/akundaje/marinovg/programs/hmmer-3.2.1/bin/hmmscan -o /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Vanderwaltozyma_polyspora_DSM70294-ASM15003v1/GCA_000150035.1_ASM15003v1_protein.PFam32-A --tblout /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Vanderwaltozyma_polyspora_DSM70294-ASM15003v1/GCA_000150035.1_ASM15003v1_protein.PFam32-A.tblout --cpu 20 /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Vanderwaltozyma_polyspora_DSM70294-ASM15003v1/GCA_000150035.1_ASM15003v1_protein.faa # Current dir: /oak/stanford/groups/akundaje/marinovg/genomes # Date: Mon Mar 25 07:28:56 2019 # [ok]