# --- full sequence ---- --- best 1 domain ---- --- domain number estimation ---- # target name accession query name accession E-value score bias E-value score bias exp reg clu ov env dom rep inc description of target #------------------- ---------- -------------------- ---------- --------- ------ ----- --------- ------ ----- --- --- --- --- --- --- --- --- --------------------- Aldedh PF00171.22 CCF47883.1 - 6.8e-15 54.5 0.0 7.9e-15 54.3 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family zf-CHY PF05495.12 CCF47883.1 - 0.0088 16.5 3.9 0.017 15.6 1.8 2.0 2 0 0 2 2 2 1 CHY zinc finger RVT_2 PF07727.14 CCF47884.1 - 2.1e-37 129.1 0.7 3.4e-37 128.4 0.7 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.27 CCF47885.1 - 3.4e-09 36.6 0.0 6.6e-09 35.6 0.0 1.5 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 CCF47886.1 - 1.1e-19 70.4 0.0 2.1e-19 69.4 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 CCF47886.1 - 1.7e-17 63.6 0.0 3.4e-17 62.6 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 CCF47886.1 - 1.7e-16 60.1 3.5 2.1e-16 59.8 0.8 2.3 2 0 0 2 2 2 1 Integrase zinc binding domain rve PF00665.26 CCF47886.1 - 1.1e-15 57.8 0.0 2.2e-15 56.9 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain Abhydrolase_1 PF00561.20 CCF47893.1 - 1.5e-21 77.2 0.0 2e-20 73.5 0.0 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CCF47893.1 - 1.4e-16 61.8 0.7 2.3e-15 57.8 0.1 2.8 2 1 0 2 2 2 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CCF47893.1 - 4.3e-16 58.9 0.0 7.1e-14 51.6 0.0 2.2 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Esterase PF00756.20 CCF47893.1 - 1.9e-06 27.7 0.0 3.7e-06 26.8 0.0 1.4 1 0 0 1 1 1 1 Putative esterase Abhydrolase_3 PF07859.13 CCF47893.1 - 9.9e-06 25.6 0.0 0.0078 16.1 0.0 2.3 2 0 0 2 2 2 2 alpha/beta hydrolase fold LIDHydrolase PF10230.9 CCF47893.1 - 0.00013 21.7 0.0 0.00028 20.6 0.0 1.5 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase Ser_hydrolase PF06821.13 CCF47893.1 - 0.00019 21.3 0.0 0.0005 20.0 0.0 1.7 1 0 0 1 1 1 1 Serine hydrolase BAAT_C PF08840.11 CCF47893.1 - 0.0003 20.8 0.0 0.43 10.5 0.0 2.4 2 0 0 2 2 2 2 BAAT / Acyl-CoA thioester hydrolase C terminal Peptidase_S9 PF00326.21 CCF47893.1 - 0.003 17.0 0.0 1 8.8 0.0 2.3 2 0 0 2 2 2 2 Prolyl oligopeptidase family Ndr PF03096.14 CCF47893.1 - 0.0066 15.2 0.0 0.012 14.3 0.0 1.3 1 0 0 1 1 1 1 Ndr family DUF915 PF06028.11 CCF47893.1 - 0.013 14.8 0.0 0.091 12.1 0.0 2.0 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF915) UPF0227 PF05728.12 CCF47893.1 - 0.04 13.8 0.0 0.07 13.1 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0227) Thioesterase PF00975.20 CCF47893.1 - 0.047 13.8 0.1 0.22 11.6 0.0 2.0 2 0 0 2 2 2 0 Thioesterase domain Abhydrolase_2 PF02230.16 CCF47893.1 - 0.064 13.0 0.0 3.9 7.2 0.0 2.6 3 0 0 3 3 3 0 Phospholipase/Carboxylesterase PGAP1 PF07819.13 CCF47893.1 - 0.16 11.6 0.0 0.27 10.9 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein Chlorophyllase2 PF12740.7 CCF47893.1 - 0.19 10.6 0.0 0.33 9.8 0.0 1.3 1 0 0 1 1 1 0 Chlorophyllase enzyme Phage_integrase PF00589.22 CCF47896.1 - 0.21 11.4 0.0 0.27 11.0 0.0 1.1 1 0 0 1 1 1 0 Phage integrase family HA2 PF04408.23 CCF47897.1 - 2.9e-17 62.9 2.2 9.9e-17 61.2 0.0 2.8 2 0 0 2 2 2 1 Helicase associated domain (HA2) Helicase_C PF00271.31 CCF47897.1 - 8.8e-15 55.0 0.0 2.3e-14 53.7 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 CCF47897.1 - 4e-11 43.0 0.0 8.1e-11 42.0 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase OB_NTP_bind PF07717.16 CCF47897.1 - 9e-11 42.0 0.2 1.8e-10 41.1 0.2 1.5 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold AAA_22 PF13401.6 CCF47897.1 - 1e-07 32.3 0.0 3.2e-07 30.7 0.0 1.8 1 0 0 1 1 1 1 AAA domain ATPase PF06745.13 CCF47897.1 - 0.019 14.3 0.0 0.051 12.9 0.0 1.7 1 0 0 1 1 1 0 KaiC AAA_23 PF13476.6 CCF47897.1 - 0.08 13.4 11.7 0.28 11.7 0.0 3.1 3 0 0 3 3 3 0 AAA domain ABC_tran PF00005.27 CCF47897.1 - 0.088 13.3 0.5 1.9 9.0 0.0 2.9 3 0 0 3 3 3 0 ABC transporter RuvA_C PF07499.13 CCF47897.1 - 2 8.9 5.2 1.8 9.1 0.2 3.3 3 0 0 3 3 3 0 RuvA, C-terminal domain P16-Arc PF04699.14 CCF47898.1 - 5.8e-47 159.9 0.0 6.5e-47 159.7 0.0 1.0 1 0 0 1 1 1 1 ARP2/3 complex 16 kDa subunit (p16-Arc) Utp12 PF04003.12 CCF47898.1 - 0.12 12.7 0.0 0.18 12.1 0.0 1.2 1 0 0 1 1 1 0 Dip2/Utp12 Family NST1 PF13945.6 CCF47900.1 - 1.5e-48 165.5 8.9 1.5e-48 165.5 8.9 6.7 4 3 1 5 5 5 1 Salt tolerance down-regulator SET PF00856.28 CCF47901.1 - 6.1e-15 56.0 0.0 6.2e-14 52.7 0.0 2.3 2 1 0 2 2 2 1 SET domain Urb2 PF10441.9 CCF47901.1 - 0.18 11.7 3.0 0.75 9.7 0.9 2.2 2 0 0 2 2 2 0 Urb2/Npa2 family RRM_1 PF00076.22 CCF47902.1 - 9.3e-14 51.0 0.0 1.4e-13 50.4 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 CCF47902.1 - 0.0061 16.5 0.0 0.011 15.7 0.0 1.5 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif SWIRM-assoc_2 PF16496.5 CCF47902.1 - 3.7 6.3 12.0 5.1 5.9 12.0 1.1 1 0 0 1 1 1 0 SWIRM-associated domain at the N-terminal rve PF00665.26 CCF47903.1 - 2.8e-08 34.0 0.5 4.6e-06 26.8 0.0 2.5 1 1 1 2 2 2 2 Integrase core domain gag_pre-integrs PF13976.6 CCF47903.1 - 3.1e-05 23.7 0.0 7.6e-05 22.5 0.0 1.7 1 0 0 1 1 1 1 GAG-pre-integrase domain NAD_Gly3P_dh_C PF07479.14 CCF47903.1 - 0.12 12.6 0.1 3.3 8.0 0.0 2.6 3 0 0 3 3 3 0 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus RVT_2 PF07727.14 CCF47904.1 - 5.4e-43 147.4 0.0 9.1e-43 146.6 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.27 CCF47905.1 - 1.1e-21 77.4 0.0 2.1e-21 76.5 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC PF00098.23 CCF47905.1 - 0.14 12.2 0.2 0.33 11.1 0.2 1.7 1 0 0 1 1 1 0 Zinc knuckle Adap_comp_sub PF00928.21 CCF47906.1 - 1.2e-23 83.8 0.0 1.7e-23 83.4 0.0 1.2 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 CCF47906.1 - 2.5e-05 24.3 0.0 4e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 Clathrin adaptor complex small chain COX5A PF02284.16 CCF47907.1 - 7.9e-42 141.5 0.2 9.8e-42 141.1 0.2 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit Va Nup35_RRM_2 PF14605.6 CCF47908.1 - 7.3e-09 35.5 0.0 0.0037 17.2 0.0 2.3 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif PWI PF01480.17 CCF47908.1 - 3.4e-08 33.7 0.0 5.8e-08 32.9 0.0 1.4 1 0 0 1 1 1 1 PWI domain RRM_1 PF00076.22 CCF47908.1 - 2.4e-07 30.5 0.1 0.029 14.2 0.0 2.8 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCCH PF00642.24 CCF47908.1 - 3.9e-06 26.6 4.2 6.9e-06 25.8 4.2 1.4 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) RRM_3 PF08777.11 CCF47908.1 - 0.0004 20.4 0.0 0.84 9.7 0.0 2.7 2 0 0 2 2 2 2 RNA binding motif zf_CCCH_4 PF18345.1 CCF47908.1 - 0.00044 20.2 6.0 0.00083 19.3 6.0 1.5 1 0 0 1 1 1 1 Zinc finger domain Torus PF16131.5 CCF47908.1 - 0.026 15.2 0.3 0.061 14.0 0.3 1.6 1 0 0 1 1 1 0 Torus domain zf-CCCH_4 PF18044.1 CCF47908.1 - 0.47 10.3 3.7 0.89 9.4 3.7 1.5 1 0 0 1 1 1 0 CCCH-type zinc finger Seryl_tRNA_N PF02403.22 CCF47908.1 - 0.73 10.1 13.8 0.062 13.5 7.2 2.2 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Ribosomal_L18A PF01775.17 CCF47909.1 - 1.3e-51 173.7 1.2 1.6e-51 173.4 1.2 1.1 1 0 0 1 1 1 1 Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A UQ_con PF00179.26 CCF47910.1 - 4.5e-34 117.1 0.0 5.8e-34 116.7 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme WD40 PF00400.32 CCF47912.1 - 2.5e-08 34.4 6.0 0.01 16.7 0.2 5.5 5 0 0 5 5 5 3 WD domain, G-beta repeat VHS PF00790.19 CCF47913.1 - 3.2e-16 59.5 0.1 5.5e-16 58.7 0.1 1.3 1 0 0 1 1 1 1 VHS domain IFRD PF05004.13 CCF47913.1 - 0.002 17.3 0.0 0.0044 16.2 0.0 1.5 1 0 0 1 1 1 1 Interferon-related developmental regulator (IFRD) MarR_2 PF12802.7 CCF47913.1 - 0.01 15.7 0.0 0.026 14.4 0.0 1.6 1 0 0 1 1 1 0 MarR family PBP1_TM PF14812.6 CCF47913.1 - 9.2 6.7 9.1 1.1 9.7 2.3 3.1 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Ras PF00071.22 CCF47914.1 - 3.5e-58 195.8 0.0 4.1e-58 195.6 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CCF47914.1 - 1.6e-35 121.9 0.0 2.4e-35 121.3 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CCF47914.1 - 3.1e-12 46.3 0.0 3.8e-12 46.0 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 CCF47914.1 - 1e-05 25.6 0.0 1.6e-05 25.0 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 CCF47914.1 - 2.5e-05 23.8 0.0 3.1e-05 23.4 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 CCF47914.1 - 3.5e-05 23.4 0.0 5.6e-05 22.8 0.0 1.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 CCF47914.1 - 0.0001 22.2 0.8 0.37 10.7 0.1 2.5 1 1 2 3 3 3 2 RsgA GTPase AAA_16 PF13191.6 CCF47914.1 - 0.0064 16.9 1.1 0.04 14.3 1.1 2.1 1 1 0 1 1 1 1 AAA ATPase domain TniB PF05621.11 CCF47914.1 - 0.042 13.3 0.0 0.095 12.1 0.0 1.7 2 0 0 2 2 2 0 Bacterial TniB protein AAA_22 PF13401.6 CCF47914.1 - 0.084 13.1 0.1 2 8.7 0.1 2.3 1 1 0 1 1 1 0 AAA domain SRPRB PF09439.10 CCF47914.1 - 0.13 11.7 0.1 0.34 10.3 0.1 1.7 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit RT_RNaseH_2 PF17919.1 CCF47916.1 - 1e-21 76.8 0.0 1.8e-21 76.1 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 CCF47916.1 - 6.7e-19 68.1 0.0 1e-18 67.6 0.0 1.2 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_2 PF07727.14 CCF47918.1 - 2.5e-26 92.8 0.0 4e-26 92.2 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) TPR_1 PF00515.28 CCF47919.1 - 1e-17 63.1 21.8 0.00078 19.2 0.1 10.9 13 0 0 13 13 13 5 Tetratricopeptide repeat TPR_2 PF07719.17 CCF47919.1 - 1.7e-17 62.1 42.3 0.0023 17.9 0.4 16.0 18 0 0 18 18 17 4 Tetratricopeptide repeat TPR_17 PF13431.6 CCF47919.1 - 4.4e-17 61.2 1.3 0.003 17.8 0.0 9.6 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_16 PF13432.6 CCF47919.1 - 5.9e-17 62.0 48.9 2.4e-05 24.9 1.7 12.7 9 3 5 14 14 14 4 Tetratricopeptide repeat TPR_8 PF13181.6 CCF47919.1 - 3.9e-13 48.5 25.1 0.18 12.1 0.1 12.3 14 0 0 14 14 13 4 Tetratricopeptide repeat TPR_14 PF13428.6 CCF47919.1 - 1.6e-11 44.0 60.4 0.00094 19.8 0.4 15.7 14 3 4 18 18 13 4 Tetratricopeptide repeat TPR_12 PF13424.6 CCF47919.1 - 2.3e-09 37.4 40.3 1.5e-05 25.2 0.0 9.9 10 0 0 10 10 9 3 Tetratricopeptide repeat TPR_19 PF14559.6 CCF47919.1 - 4.2e-08 33.6 33.8 0.51 10.9 3.9 10.6 10 1 2 12 12 12 4 Tetratricopeptide repeat TPR_11 PF13414.6 CCF47919.1 - 4.6e-06 26.2 11.6 0.25 11.1 0.1 7.8 7 1 0 7 7 7 1 TPR repeat TPR_9 PF13371.6 CCF47919.1 - 6.5e-06 26.2 15.0 1.5 9.0 0.0 7.4 9 0 0 9 9 6 3 Tetratricopeptide repeat TPR_6 PF13174.6 CCF47919.1 - 1.2e-05 25.6 24.2 0.43 11.3 0.3 11.3 13 0 0 13 13 11 1 Tetratricopeptide repeat ANAPC3 PF12895.7 CCF47919.1 - 5.8e-05 23.2 9.0 0.075 13.3 0.0 5.9 6 0 0 6 6 6 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 CCF47919.1 - 9.4e-05 22.2 17.0 1.1 9.5 0.0 8.0 9 0 0 9 9 7 2 Tetratricopeptide repeat TPR_22 PF18833.1 CCF47919.1 - 0.00026 21.1 0.2 0.0011 19.1 0.2 2.1 1 0 0 1 1 1 1 Tetratricopeptide repeat ChAPs PF09295.10 CCF47919.1 - 0.00066 18.8 0.2 0.047 12.7 0.0 3.0 3 0 0 3 3 3 1 ChAPs (Chs5p-Arf1p-binding proteins) NARP1 PF12569.8 CCF47919.1 - 0.0038 16.2 4.0 0.47 9.3 0.0 4.5 5 0 0 5 5 5 1 NMDA receptor-regulated protein 1 DUF760 PF05542.11 CCF47919.1 - 0.098 13.0 0.4 2.4 8.6 0.2 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF760) NopRA1 PF16201.5 CCF47919.1 - 0.78 9.3 4.7 0.6 9.7 1.5 2.5 2 1 0 3 3 3 0 Nucleolar pre-ribosomal-associated protein 1 TPR_10 PF13374.6 CCF47919.1 - 4.7 7.2 8.6 25 4.9 0.1 4.5 5 0 0 5 5 3 0 Tetratricopeptide repeat Apolipoprotein PF01442.18 CCF47920.1 - 2.7e-05 24.2 6.4 4.8e-05 23.3 6.4 1.3 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain Baculo_PEP_C PF04513.12 CCF47920.1 - 3.6e-05 23.8 7.5 0.0077 16.3 1.3 2.6 1 1 0 2 2 2 2 Baculovirus polyhedron envelope protein, PEP, C terminus Gp58 PF07902.11 CCF47920.1 - 0.0015 16.9 1.3 0.0022 16.4 1.3 1.1 1 0 0 1 1 1 1 gp58-like protein DHC PF09626.10 CCF47920.1 - 0.038 14.9 3.7 4.3 8.2 0.5 2.7 2 0 0 2 2 2 0 Dihaem cytochrome c Dor1 PF04124.12 CCF47920.1 - 0.058 12.1 1.2 0.093 11.4 1.2 1.3 1 0 0 1 1 1 0 Dor1-like family Collagen_mid PF15984.5 CCF47920.1 - 0.077 12.7 0.0 0.13 12.0 0.0 1.3 1 0 0 1 1 1 0 Bacterial collagen, middle region zf-AD PF07776.15 CCF47920.1 - 0.091 13.0 3.4 0.11 12.7 1.3 2.2 2 0 0 2 2 2 0 Zinc-finger associated domain (zf-AD) YusW PF14039.6 CCF47920.1 - 0.12 12.9 0.5 0.32 11.6 0.4 1.8 1 1 0 1 1 1 0 YusW-like protein MnmE_helical PF12631.7 CCF47920.1 - 0.14 12.3 4.7 0.31 11.2 4.7 1.5 1 1 0 1 1 1 0 MnmE helical domain DUF4455 PF14643.6 CCF47920.1 - 0.17 10.5 4.5 0.26 9.9 3.8 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4455) FlxA PF14282.6 CCF47920.1 - 0.27 11.2 8.9 0.26 11.3 5.1 2.3 1 1 1 2 2 2 0 FlxA-like protein Spc7 PF08317.11 CCF47920.1 - 0.33 9.8 5.3 0.33 9.8 3.7 1.7 1 1 1 2 2 2 0 Spc7 kinetochore protein Prominin PF05478.11 CCF47920.1 - 0.68 7.8 4.8 13 3.6 0.9 1.7 1 1 0 1 1 1 0 Prominin THOC7 PF05615.13 CCF47920.1 - 2.4 8.4 5.2 36 4.6 5.3 2.3 1 1 0 1 1 1 0 Tho complex subunit 7 Cep57_CLD_2 PF14197.6 CCF47920.1 - 2.5 8.3 4.8 9.5 6.4 1.2 2.9 2 1 1 3 3 3 0 Centrosome localisation domain of PPC89 DUF2205 PF10224.9 CCF47920.1 - 6.3 6.9 7.2 1.2 9.2 0.4 3.2 3 1 0 3 3 3 0 Short coiled-coil protein SUR7 PF06687.12 CCF47921.1 - 1.8e-25 89.8 7.8 2.5e-25 89.4 7.8 1.1 1 0 0 1 1 1 1 SUR7/PalI family MMPL PF03176.15 CCF47921.1 - 0.25 10.2 3.5 0.45 9.4 3.5 1.3 1 0 0 1 1 1 0 MMPL family ANTH PF07651.16 CCF47922.1 - 7.1e-75 251.5 0.3 7.1e-75 251.5 0.3 2.3 2 0 0 2 2 2 1 ANTH domain I_LWEQ PF01608.17 CCF47922.1 - 8.9e-55 185.1 9.8 8.9e-55 185.1 9.8 5.0 3 1 0 4 4 4 2 I/LWEQ domain ENTH PF01417.20 CCF47922.1 - 1.5e-06 28.3 0.5 1.5e-05 25.0 0.1 2.9 2 0 0 2 2 2 1 ENTH domain PCI PF01399.27 CCF47923.1 - 4.7e-19 68.8 0.0 7.3e-18 65.0 0.0 2.6 2 1 0 2 2 2 1 PCI domain RPN5_C PF18098.1 CCF47923.1 - 5.2e-13 48.8 0.8 1.3e-12 47.5 0.8 1.7 1 0 0 1 1 1 1 26S proteasome regulatory subunit RPN5 C-terminal domain TAF4 PF05236.14 CCF47923.1 - 0.015 15.1 12.5 0.029 14.1 12.5 1.5 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family DDHD PF02862.17 CCF47923.1 - 0.048 13.8 1.0 0.099 12.8 1.0 1.7 1 0 0 1 1 1 0 DDHD domain DUF4228 PF14009.6 CCF47923.1 - 0.085 13.2 2.4 0.18 12.2 2.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4228) CLN3 PF02487.17 CCF47923.1 - 0.099 11.7 1.8 0.16 11.0 1.8 1.2 1 0 0 1 1 1 0 CLN3 protein Vfa1 PF08432.10 CCF47923.1 - 0.27 11.6 13.6 0.74 10.1 13.6 1.7 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 PTPRCAP PF15713.5 CCF47923.1 - 0.67 10.2 11.9 1.4 9.2 11.9 1.5 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated RNA_pol_Rpc4 PF05132.14 CCF47923.1 - 1.5 9.2 6.8 3.8 7.9 6.8 1.6 1 0 0 1 1 1 0 RNA polymerase III RPC4 Presenilin PF01080.17 CCF47923.1 - 3.5 6.3 7.0 5.7 5.6 7.0 1.2 1 0 0 1 1 1 0 Presenilin Connexin PF00029.19 CCF47923.1 - 6 6.6 6.3 13 5.4 6.3 1.6 1 0 0 1 1 1 0 Connexin Pkinase PF00069.25 CCF47924.1 - 2.1e-27 96.2 0.0 2.8e-27 95.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF47924.1 - 5.3e-16 58.7 0.0 7e-16 58.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CCF47924.1 - 1.1e-09 37.6 0.1 1.7e-09 37.0 0.1 1.3 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 CCF47924.1 - 0.00047 20.2 0.0 0.0081 16.1 0.0 2.4 2 0 0 2 2 2 1 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.11 CCF47924.1 - 0.04 12.9 0.1 0.06 12.3 0.1 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Kdo PF06293.14 CCF47924.1 - 0.079 12.3 0.1 0.14 11.5 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF2183 PF09949.9 CCF47926.1 - 1.3e-23 83.2 0.0 6.2e-23 81.0 0.0 2.3 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2183) DUF1489 PF07370.11 CCF47926.1 - 0.13 12.0 0.8 11 5.7 0.0 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF1489) RVT_1 PF00078.27 CCF47928.1 - 1.7e-08 34.3 0.0 3.2e-08 33.4 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 CCF47928.1 - 2.6e-05 24.4 0.0 0.00012 22.3 0.0 1.9 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 CCF47928.1 - 0.0015 18.6 0.0 0.0086 16.1 0.0 2.1 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase SNARE PF05739.19 CCF47929.1 - 1e-15 57.4 0.1 2.1e-15 56.4 0.1 1.5 1 0 0 1 1 1 1 SNARE domain Syntaxin-5_N PF11416.8 CCF47929.1 - 8.5e-09 34.4 0.1 3.9e-08 32.3 0.0 2.1 2 0 0 2 2 2 1 Syntaxin-5 N-terminal, Sly1p-binding domain Syntaxin PF00804.25 CCF47929.1 - 1.9e-07 31.0 8.5 0.00056 19.6 1.1 2.3 2 0 0 2 2 2 2 Syntaxin Syntaxin-18_N PF10496.9 CCF47929.1 - 0.0019 18.4 2.3 0.002 18.3 0.3 2.2 2 0 0 2 2 2 1 SNARE-complex protein Syntaxin-18 N-terminus FlaC_arch PF05377.11 CCF47929.1 - 0.038 14.4 2.0 0.26 11.7 2.0 2.3 1 1 0 1 1 1 0 Flagella accessory protein C (FlaC) SlyX PF04102.12 CCF47929.1 - 0.19 12.3 5.0 0.46 11.1 0.4 2.8 2 1 1 3 3 3 0 SlyX DUF1664 PF07889.12 CCF47929.1 - 0.26 11.3 3.1 0.54 10.3 0.7 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Prominin PF05478.11 CCF47929.1 - 0.36 8.7 3.4 0.1 10.5 0.5 1.4 2 0 0 2 2 2 0 Prominin DUF16 PF01519.16 CCF47929.1 - 0.44 11.0 3.6 0.38 11.3 0.7 2.1 2 0 0 2 2 2 0 Protein of unknown function DUF16 BLOC1_2 PF10046.9 CCF47929.1 - 0.65 10.3 4.6 3.2 8.1 1.1 3.1 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Cor1 PF04803.12 CCF47929.1 - 0.94 9.7 5.9 2.9 8.1 1.8 2.3 2 0 0 2 2 2 0 Cor1/Xlr/Xmr conserved region DUF148 PF02520.17 CCF47929.1 - 1.4 9.0 7.7 0.43 10.7 1.3 2.8 2 1 1 3 3 3 0 Domain of unknown function DUF148 DNA_pol_B_thumb PF14791.6 CCF47930.1 - 4.5e-20 71.6 0.2 1.3e-19 70.1 0.1 1.9 2 0 0 2 2 2 1 DNA polymerase beta thumb DNA_pol_B_palm PF14792.6 CCF47930.1 - 1.6e-10 41.2 0.0 4.9e-10 39.6 0.0 1.8 2 0 0 2 2 2 1 DNA polymerase beta palm HHH_8 PF14716.6 CCF47930.1 - 3.4e-07 30.5 0.2 1.8e-06 28.2 0.2 2.2 1 1 0 1 1 1 1 Helix-hairpin-helix domain DNA_pol_lambd_f PF10391.9 CCF47930.1 - 0.00034 20.4 0.0 0.00077 19.2 0.0 1.6 1 0 0 1 1 1 1 Fingers domain of DNA polymerase lambda IMUP PF15761.5 CCF47930.1 - 1.8 9.3 11.5 3.7 8.3 11.5 1.5 1 0 0 1 1 1 0 Immortalisation up-regulated protein SR-25 PF10500.9 CCF47930.1 - 4.2 6.9 12.4 6.8 6.2 12.4 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Abhydrolase_6 PF12697.7 CCF47931.1 - 9.5e-05 23.1 0.0 0.00018 22.2 0.0 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.7 CCF47931.1 - 0.0085 15.9 0.4 0.42 10.4 0.0 2.6 2 0 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.16 CCF47931.1 - 0.027 14.3 0.0 0.33 10.7 0.0 2.3 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase Syndecan PF01034.20 CCF47931.1 - 1.8 8.5 5.5 5.1 7.1 0.0 2.4 2 0 0 2 2 2 0 Syndecan domain ABC_membrane PF00664.23 CCF47932.1 - 1.6e-39 136.2 6.8 2e-39 135.9 6.8 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 CCF47932.1 - 1.1e-35 123.1 0.0 2.2e-34 118.9 0.0 2.4 2 0 0 2 2 2 1 ABC transporter SMC_N PF02463.19 CCF47932.1 - 5.4e-06 26.0 0.1 0.00062 19.3 0.0 2.5 2 1 1 3 3 3 1 RecF/RecN/SMC N terminal domain AAA PF00004.29 CCF47932.1 - 0.001 19.5 0.0 0.011 16.2 0.0 2.2 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_21 PF13304.6 CCF47932.1 - 0.0052 16.6 0.1 0.08 12.7 0.0 2.2 1 1 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 CCF47932.1 - 0.0071 16.7 0.0 0.016 15.6 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 CCF47932.1 - 0.019 15.3 0.0 0.097 12.9 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 CCF47932.1 - 0.023 14.4 0.0 0.06 13.1 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_23 PF13476.6 CCF47932.1 - 0.057 13.9 0.0 0.12 12.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_15 PF13175.6 CCF47932.1 - 0.061 13.0 0.0 0.1 12.3 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain RsgA_GTPase PF03193.16 CCF47932.1 - 0.12 12.2 0.0 0.28 11.1 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase AAA_5 PF07728.14 CCF47932.1 - 0.13 12.3 0.0 0.76 9.8 0.0 2.2 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) Med13_C PF06333.12 CCF47932.1 - 0.13 11.5 0.7 0.22 10.8 0.7 1.4 1 0 0 1 1 1 0 Mediator complex subunit 13 C-terminal domain Archease PF01951.16 CCF47933.1 - 0.051 13.8 0.7 1.7 8.9 0.0 3.1 4 0 0 4 4 4 0 Archease protein family (MTH1598/TM1083) Aminotran_1_2 PF00155.21 CCF47934.1 - 4.9e-92 308.9 0.0 5.7e-92 308.7 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II M_domain PF12938.7 CCF47935.1 - 0.41 10.4 8.6 0.78 9.5 8.6 1.4 1 0 0 1 1 1 0 M domain of GW182 Retrotrans_gag PF03732.17 CCF47936.1 - 0.0059 16.9 0.4 0.0095 16.2 0.4 1.6 1 1 0 1 1 1 1 Retrotransposon gag protein Rsa3 PF14615.6 CCF47937.1 - 2.6e-11 42.9 0.0 2.6e-11 42.9 0.0 1.7 2 0 0 2 2 2 1 Ribosome-assembly protein 3 KI67R PF08065.12 CCF47937.1 - 0.03 14.9 2.7 0.03 14.9 2.7 3.3 1 1 2 3 3 3 0 KI67R (NUC007) repeat DUF3350 PF11830.8 CCF47937.1 - 0.099 13.0 0.4 0.099 13.0 0.4 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3350) RVT_2 PF07727.14 CCF47938.1 - 8.2e-12 45.3 0.0 1.6e-11 44.3 0.0 1.5 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 CCF47939.1 - 5.9e-08 32.9 0.0 1.1e-07 32.0 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain gag_pre-integrs PF13976.6 CCF47939.1 - 1.2e-05 25.1 3.0 1.2e-05 25.1 3.0 2.2 3 0 0 3 3 3 1 GAG-pre-integrase domain RVT_2 PF07727.14 CCF47940.1 - 3.2e-45 154.7 0.1 3.6e-45 154.5 0.1 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.27 CCF47940.1 - 0.0042 16.6 0.0 0.0071 15.9 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Hid1 PF12722.7 CCF47943.1 - 0.14 10.3 0.0 0.16 10.1 0.0 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Pox_A12 PF04651.13 CCF47944.1 - 0.0028 17.7 0.0 0.0033 17.5 0.0 1.2 1 0 0 1 1 1 1 Poxvirus A12 protein RVT_2 PF07727.14 CCF47948.1 - 4.5e-24 85.4 0.1 7.5e-24 84.7 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Crr6 PF08847.11 CCF47948.1 - 0.017 14.8 0.2 0.042 13.5 0.0 1.8 2 0 0 2 2 2 0 Chlororespiratory reduction 6 Retrotran_gag_2 PF14223.6 CCF47949.1 - 5.5e-11 42.3 0.2 2e-10 40.5 0.1 1.9 1 1 1 2 2 2 1 gag-polypeptide of LTR copia-type zf-CCHC PF00098.23 CCF47949.1 - 0.0063 16.5 2.7 0.013 15.6 1.8 2.0 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC_3 PF13917.6 CCF47949.1 - 0.063 13.2 2.3 0.16 12.0 2.3 1.6 1 0 0 1 1 1 0 Zinc knuckle Glycos_transf_N PF04413.16 CCF47949.1 - 0.13 11.9 0.0 11 5.6 0.0 2.5 2 0 0 2 2 2 0 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase) NTP_transf_3 PF12804.7 CCF47950.1 - 0.15 12.4 0.0 0.23 11.8 0.0 1.2 1 0 0 1 1 1 0 MobA-like NTP transferase domain Intein_splicing PF14890.6 CCF47950.1 - 0.59 10.1 2.2 6.5 6.7 0.1 2.0 1 1 1 2 2 2 0 Intein splicing domain GATA PF00320.27 CCF47951.1 - 7.5e-16 57.4 2.8 1.2e-15 56.7 2.8 1.4 1 0 0 1 1 1 1 GATA zinc finger Pdase_C33_assoc PF14756.6 CCF47951.1 - 0.02 14.8 0.0 0.02 14.8 0.0 1.7 2 0 0 2 2 2 0 Peptidase_C33-associated domain Macoilin PF09726.9 CCF47951.1 - 2.3 6.6 9.3 3.6 6.0 9.3 1.2 1 0 0 1 1 1 0 Macoilin family BAF1_ABF1 PF04684.13 CCF47951.1 - 7.1 5.6 13.7 11 4.9 13.7 1.3 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Peptidase_M43 PF05572.13 CCF47952.1 - 7.6e-17 61.6 0.6 1.1e-16 61.1 0.6 1.4 1 0 0 1 1 1 1 Pregnancy-associated plasma protein-A Reprolysin_5 PF13688.6 CCF47952.1 - 7.4e-07 29.5 2.9 7.9e-07 29.4 2.1 1.4 1 1 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.6 CCF47952.1 - 8.2e-06 26.3 0.4 2e-05 25.1 0.1 1.8 2 0 0 2 2 2 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M66 PF10462.9 CCF47952.1 - 0.023 13.7 1.2 0.042 12.8 0.2 1.8 2 0 0 2 2 2 0 Peptidase M66 Peptidase_M10 PF00413.24 CCF47952.1 - 0.035 13.9 0.0 0.052 13.4 0.0 1.3 1 0 0 1 1 1 0 Matrixin zf-CHCC PF10276.9 CCF47954.1 - 1.4e-17 63.4 1.1 2.1e-17 62.9 1.1 1.3 1 0 0 1 1 1 1 Zinc-finger domain zinc_ribbon_2 PF13240.6 CCF47954.1 - 0.029 14.1 0.2 0.053 13.3 0.2 1.3 1 0 0 1 1 1 0 zinc-ribbon domain OTU PF02338.19 CCF47958.1 - 1.5e-09 38.4 0.0 3.6e-09 37.2 0.0 1.6 1 1 0 1 1 1 1 OTU-like cysteine protease PAH PF02671.21 CCF47958.1 - 0.063 13.4 0.1 0.16 12.1 0.1 1.8 1 1 0 1 1 1 0 Paired amphipathic helix repeat LRV PF01816.17 CCF47958.1 - 0.19 12.2 0.3 0.43 11.1 0.3 1.6 1 0 0 1 1 1 0 Leucine rich repeat variant F_actin_cap_B PF01115.17 CCF47959.1 - 4.3e-89 298.2 0.0 5.1e-89 298.0 0.0 1.1 1 0 0 1 1 1 1 F-actin capping protein, beta subunit gag_pre-integrs PF13976.6 CCF47962.1 - 8.2e-08 32.0 0.1 1.4e-07 31.3 0.1 1.4 1 0 0 1 1 1 1 GAG-pre-integrase domain NinF PF05810.12 CCF47962.1 - 0.017 15.0 0.0 0.034 14.0 0.0 1.4 1 0 0 1 1 1 0 NinF protein TgMIC1 PF11476.8 CCF47962.1 - 0.065 13.0 0.0 0.1 12.3 0.0 1.3 1 0 0 1 1 1 0 Toxoplasma gondii micronemal protein 1 TgMIC1 DUF3584 PF12128.8 CCF47963.1 - 0.16 9.4 41.0 0.25 8.8 41.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) SHE3 PF17078.5 CCF47963.1 - 0.87 9.3 36.1 0.043 13.5 13.7 3.6 1 1 2 3 3 3 0 SWI5-dependent HO expression protein 3 Spc7 PF08317.11 CCF47963.1 - 4.2 6.2 47.3 2.4 7.0 26.2 2.5 1 1 1 2 2 2 0 Spc7 kinetochore protein Ras PF00071.22 CCF47966.1 - 1.1e-56 190.9 0.0 1.3e-56 190.7 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CCF47966.1 - 1.1e-30 106.3 0.0 1.7e-30 105.7 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CCF47966.1 - 2.8e-12 46.4 0.0 3.2e-12 46.3 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 CCF47966.1 - 3.3e-07 30.4 0.0 6.1e-07 29.5 0.0 1.4 2 0 0 2 2 2 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 CCF47966.1 - 0.00011 21.6 0.0 0.00018 20.9 0.0 1.3 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 CCF47966.1 - 0.00017 21.6 0.2 0.0042 17.0 0.1 2.3 1 1 0 2 2 2 1 RsgA GTPase GTP_EFTU PF00009.27 CCF47966.1 - 0.00029 20.4 0.0 0.011 15.3 0.0 2.2 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain PduV-EutP PF10662.9 CCF47966.1 - 0.0026 17.5 0.0 0.23 11.2 0.0 2.2 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation Septin PF00735.18 CCF47966.1 - 0.0062 15.9 0.1 0.076 12.3 0.0 2.2 2 0 0 2 2 2 1 Septin cobW PF02492.19 CCF47966.1 - 0.0074 15.9 0.0 0.021 14.4 0.0 1.7 1 1 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_16 PF13191.6 CCF47966.1 - 0.0081 16.6 0.1 0.02 15.3 0.1 1.9 1 1 0 1 1 1 1 AAA ATPase domain ATP_bind_1 PF03029.17 CCF47966.1 - 0.011 15.5 0.3 0.47 10.2 0.0 2.1 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein AAA_22 PF13401.6 CCF47966.1 - 0.012 15.9 0.0 0.026 14.8 0.0 1.6 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 CCF47966.1 - 0.016 14.9 0.0 0.042 13.6 0.0 1.7 2 0 0 2 2 2 0 AAA domain SRPRB PF09439.10 CCF47966.1 - 0.024 14.1 0.0 0.042 13.3 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_7 PF12775.7 CCF47966.1 - 0.035 13.6 0.0 0.056 13.0 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_5 PF07728.14 CCF47966.1 - 0.036 14.1 0.0 0.075 13.0 0.0 1.7 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) ATPase_2 PF01637.18 CCF47966.1 - 0.053 13.4 0.3 0.099 12.5 0.0 1.5 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea Glyco_hydro_75 PF07335.11 CCF47966.1 - 0.1 12.9 0.0 0.15 12.3 0.0 1.4 1 0 0 1 1 1 0 Fungal chitosanase of glycosyl hydrolase group 75 NACHT PF05729.12 CCF47966.1 - 0.11 12.4 0.0 0.18 11.7 0.0 1.3 1 0 0 1 1 1 0 NACHT domain TniB PF05621.11 CCF47966.1 - 0.16 11.3 0.0 0.25 10.7 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein RVT_2 PF07727.14 CCF47967.1 - 5.2e-27 95.1 0.0 5.8e-27 94.9 0.0 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) PDEase_I_N PF08499.12 CCF47968.1 - 0.045 13.6 0.2 0.13 12.1 0.2 1.7 1 0 0 1 1 1 0 3'5'-cyclic nucleotide phosphodiesterase N-terminal rve PF00665.26 CCF47969.1 - 0.00071 19.8 0.1 0.0011 19.1 0.1 1.3 1 0 0 1 1 1 1 Integrase core domain 2-oxoacid_dh PF00198.23 CCF47970.1 - 6.5e-77 258.1 0.2 8.6e-77 257.7 0.2 1.2 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 CCF47970.1 - 4e-21 74.6 1.4 7.3e-21 73.8 0.3 2.1 2 0 0 2 2 2 1 Biotin-requiring enzyme E3_binding PF02817.17 CCF47970.1 - 1e-15 57.8 0.2 2.5e-15 56.5 0.2 1.7 1 0 0 1 1 1 1 e3 binding domain SR-25 PF10500.9 CCF47970.1 - 0.0021 17.7 12.8 0.0021 17.7 12.8 2.1 2 0 0 2 2 2 1 Nuclear RNA-splicing-associated protein DUF755 PF05501.11 CCF47970.1 - 0.009 16.3 6.4 0.009 16.3 6.4 2.3 3 0 0 3 3 2 1 Domain of unknown function (DUF755) Presenilin PF01080.17 CCF47970.1 - 0.016 14.0 1.3 0.023 13.5 1.3 1.2 1 0 0 1 1 1 0 Presenilin GRA6 PF05084.13 CCF47970.1 - 0.039 13.9 3.7 0.076 13.0 3.7 1.4 1 0 0 1 1 1 0 Granule antigen protein (GRA6) Ndc1_Nup PF09531.10 CCF47970.1 - 0.055 12.2 3.2 0.1 11.3 3.2 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup RNA_pol_Rpc4 PF05132.14 CCF47970.1 - 0.097 13.1 2.9 0.28 11.6 2.9 1.7 1 0 0 1 1 1 0 RNA polymerase III RPC4 Apt1 PF10351.9 CCF47970.1 - 0.11 11.3 3.0 0.14 11.0 3.0 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain DUF4692 PF15763.5 CCF47970.1 - 0.27 11.7 6.5 0.67 10.4 6.5 1.6 1 0 0 1 1 1 0 Regulator of human erythroid cell expansion (RHEX) SspB PF04386.13 CCF47970.1 - 0.45 10.4 4.1 6.9 6.5 2.9 2.4 2 0 0 2 2 2 0 Stringent starvation protein B CCDC106 PF15794.5 CCF47970.1 - 1.1 8.9 6.2 2.1 8.0 6.2 1.4 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 MFS_1 PF07690.16 CCF47971.1 - 1.9e-14 53.3 27.2 4.3e-14 52.2 26.5 1.7 1 1 1 2 2 2 1 Major Facilitator Superfamily MFS_2 PF13347.6 CCF47971.1 - 6e-09 35.0 8.1 7.5e-09 34.6 8.1 1.2 1 0 0 1 1 1 1 MFS/sugar transport protein MFS_1_like PF12832.7 CCF47971.1 - 7.1e-05 21.8 9.7 9.4e-05 21.4 9.7 1.1 1 0 0 1 1 1 1 MFS_1 like family Sugar_tr PF00083.24 CCF47971.1 - 0.13 11.1 13.7 0.0092 14.9 7.6 1.7 1 1 1 2 2 2 0 Sugar (and other) transporter RVT_1 PF00078.27 CCF47973.1 - 3.1e-27 95.5 0.0 5.9e-27 94.6 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Usp PF00582.26 CCF47976.1 - 1e-22 81.2 0.7 1e-22 81.2 0.7 2.3 2 0 0 2 2 2 1 Universal stress protein family Vps51 PF08700.11 CCF47977.1 - 2.7e-16 59.4 0.1 4.8e-16 58.6 0.1 1.4 1 0 0 1 1 1 1 Vps51/Vps67 Dor1 PF04124.12 CCF47977.1 - 0.021 13.5 0.2 0.027 13.2 0.2 1.1 1 0 0 1 1 1 0 Dor1-like family COG5 PF10392.9 CCF47977.1 - 0.049 13.8 2.2 0.082 13.1 2.2 1.3 1 0 0 1 1 1 0 Golgi transport complex subunit 5 FlgN PF05130.12 CCF47977.1 - 0.24 11.9 1.0 0.54 10.8 0.2 1.8 2 0 0 2 2 2 0 FlgN protein Pribosyltran PF00156.27 CCF47978.1 - 0.00045 19.8 0.0 0.001 18.6 0.0 1.6 1 1 0 1 1 1 1 Phosphoribosyl transferase domain EC042_2821 PF18740.1 CCF47978.1 - 0.16 11.8 0.0 0.28 11.0 0.0 1.4 1 0 0 1 1 1 0 EC042_2821-lke REase 2OG-FeII_Oxy_2 PF13532.6 CCF47979.1 - 1.7e-09 38.2 0.0 2.9e-09 37.4 0.0 1.5 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily adh_short PF00106.25 CCF47980.1 - 8.3e-25 87.4 1.6 1.8e-20 73.2 1.1 2.9 1 1 2 3 3 3 2 short chain dehydrogenase adh_short_C2 PF13561.6 CCF47980.1 - 2.9e-16 59.8 0.1 4e-14 52.7 0.3 2.3 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF47980.1 - 7.1e-07 29.3 0.3 1.5e-06 28.2 0.3 1.5 1 1 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 CCF47980.1 - 7.5e-06 25.3 0.4 8.9e-06 25.0 0.4 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.12 CCF47980.1 - 5.8e-05 22.4 0.0 0.00016 20.9 0.0 1.6 1 1 0 1 1 1 1 Male sterility protein Epimerase PF01370.21 CCF47980.1 - 0.00022 20.8 0.1 0.031 13.7 0.0 2.1 2 0 0 2 2 2 2 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 CCF47980.1 - 0.0012 17.9 0.2 0.0017 17.4 0.2 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Semialdhyde_dh PF01118.24 CCF47980.1 - 0.054 13.9 0.0 0.1 13.0 0.0 1.5 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain ATP-synt_F PF01990.17 CCF47980.1 - 0.16 12.3 0.0 16 5.9 0.0 2.4 2 0 0 2 2 2 0 ATP synthase (F/14-kDa) subunit DUF3479 PF11965.8 CCF47980.1 - 0.16 12.1 0.0 11 6.1 0.0 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF3479) Sugar_tr PF00083.24 CCF47981.1 - 3.1e-72 243.9 11.6 3.7e-72 243.6 11.6 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF47981.1 - 1.9e-16 59.9 15.8 1.9e-16 59.9 15.8 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily OTU PF02338.19 CCF47982.1 - 1.6e-13 51.2 0.0 3.9e-13 50.0 0.0 1.6 2 0 0 2 2 2 1 OTU-like cysteine protease FmiP_Thoc5 PF09766.9 CCF47982.1 - 0.2 10.9 5.2 1.7 7.8 0.2 2.4 2 0 0 2 2 2 0 Fms-interacting protein/Thoc5 AT_hook PF02178.19 CCF47982.1 - 0.23 11.4 5.7 0.7 10.0 5.7 1.9 1 0 0 1 1 1 0 AT hook motif DUF1199 PF06712.11 CCF47982.1 - 0.54 10.3 3.9 2.4 8.3 3.9 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1199) DUF5560 PF17715.1 CCF47984.1 - 0.06 12.8 0.3 0.11 11.9 0.3 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5560) DUF2608 PF11019.8 CCF47986.1 - 0.047 13.2 2.5 0.062 12.8 1.1 1.8 2 1 0 2 2 2 0 Protein of unknown function (DUF2608) ArfGap PF01412.18 CCF47987.1 - 2e-34 118.2 0.3 4.4e-34 117.1 0.3 1.6 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf PH PF00169.29 CCF47987.1 - 1.8e-11 44.5 0.0 6.3e-11 42.7 0.0 2.0 2 0 0 2 2 2 1 PH domain BAR_3 PF16746.5 CCF47987.1 - 0.035 13.8 0.2 0.088 12.5 0.2 1.7 1 0 0 1 1 1 0 BAR domain of APPL family PH_9 PF15410.6 CCF47987.1 - 0.15 12.4 0.0 0.61 10.5 0.0 2.0 1 1 0 1 1 1 0 Pleckstrin homology domain tRNA-synt_1c PF00749.21 CCF47988.1 - 3.1e-79 266.1 0.0 4.3e-79 265.6 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain Rft-1 PF04506.13 CCF47989.1 - 2.8e-108 362.9 0.1 3.4e-108 362.6 0.1 1.0 1 0 0 1 1 1 1 Rft protein Rnf-Nqr PF02508.14 CCF47989.1 - 0.0059 16.6 0.6 0.023 14.7 0.6 2.1 1 0 0 1 1 1 1 Rnf-Nqr subunit, membrane protein Polysacc_synt_3 PF13440.6 CCF47989.1 - 0.0084 15.4 0.7 0.67 9.1 0.0 3.0 3 0 0 3 3 3 2 Polysaccharide biosynthesis protein THOC2_N PF16134.5 CCF47990.1 - 2.5e-185 617.8 0.0 4.7e-185 616.8 0.0 1.5 1 0 0 1 1 1 1 THO complex subunit 2 N-terminus Tho2 PF11262.8 CCF47990.1 - 2.8e-90 302.6 0.0 2.8e-90 302.6 0.0 2.1 2 0 0 2 2 2 1 Transcription factor/nuclear export subunit protein 2 Thoc2 PF11732.8 CCF47990.1 - 4.7e-31 106.7 0.1 1.9e-30 104.7 0.1 2.1 2 0 0 2 2 2 1 Transcription- and export-related complex subunit RhoGEF PF00621.20 CCF47991.1 - 2.5e-31 109.3 0.0 4.9e-31 108.4 0.0 1.5 1 0 0 1 1 1 1 RhoGEF domain Lge1 PF11488.8 CCF47991.1 - 0.12 12.5 2.7 1.5 9.1 0.3 2.7 2 0 0 2 2 2 0 Transcriptional regulatory protein LGE1 Chibby PF14645.6 CCF47991.1 - 0.35 11.3 11.0 1.8 9.0 0.8 3.5 2 1 1 3 3 3 0 Chibby family TEX12 PF15219.6 CCF47991.1 - 0.43 10.9 2.1 1 9.7 0.4 2.5 2 0 0 2 2 2 0 Testis-expressed 12 SOGA PF11365.8 CCF47991.1 - 1.2 10.3 14.4 5.4 8.2 0.9 4.3 4 1 1 5 5 5 0 Protein SOGA HALZ PF02183.18 CCF47991.1 - 1.6 9.0 6.2 0.3 11.3 1.0 2.3 2 0 0 2 2 2 0 Homeobox associated leucine zipper RRM_1 PF00076.22 CCF47992.1 - 5e-37 125.6 1.2 1.5e-18 66.4 0.1 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 CCF47992.1 - 7.6e-05 22.3 0.0 0.0017 18.0 0.0 2.3 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 CCF47992.1 - 0.00092 19.2 1.3 0.17 11.9 0.0 2.9 2 1 0 2 2 2 1 Limkain b1 RRM_7 PF16367.5 CCF47992.1 - 0.015 15.4 0.1 3.6 7.8 0.0 3.1 2 2 0 2 2 2 0 RNA recognition motif Herpes_DNAp_acc PF04929.12 CCF47992.1 - 0.94 8.4 11.5 1.7 7.5 11.5 1.5 1 0 0 1 1 1 0 Herpes DNA replication accessory factor GREB1 PF15782.5 CCF47992.1 - 1.9 5.5 6.7 2.2 5.3 6.7 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Draxin PF15550.6 CCF47992.1 - 2.5 7.9 17.2 1.1 9.1 14.8 1.4 1 1 0 1 1 1 0 Draxin PHM7_cyt PF14703.6 CCF47992.1 - 3.1 8.0 9.5 0.49 10.6 0.1 3.3 2 2 0 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter OB_RNB PF08206.11 CCF47992.1 - 8.3 6.2 7.0 2 8.2 0.1 3.3 4 0 0 4 4 4 0 Ribonuclease B OB domain LtrA PF06772.11 CCF47993.1 - 1.7e-17 63.7 22.0 1.7e-17 63.7 22.0 3.0 2 1 0 2 2 2 1 Bacterial low temperature requirement A protein (LtrA) EnY2 PF10163.9 CCF47994.1 - 8.1e-20 71.0 0.0 1.1e-19 70.6 0.0 1.2 1 0 0 1 1 1 1 Transcription factor e(y)2 zf-CCHC PF00098.23 CCF47995.1 - 0.0001 22.2 0.8 0.00023 21.1 0.8 1.6 1 0 0 1 1 1 1 Zinc knuckle Retrotran_gag_2 PF14223.6 CCF47995.1 - 0.00085 19.0 2.0 0.0016 18.1 2.0 1.6 1 1 0 1 1 1 1 gag-polypeptide of LTR copia-type FeS PF04060.13 CCF47996.1 - 0.047 13.3 0.1 0.12 12.1 0.1 1.6 1 0 0 1 1 1 0 Putative Fe-S cluster DUF1771 PF08590.10 CCF47998.1 - 1.2e-12 47.9 6.2 1.2e-12 47.9 6.2 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF1771) zf-CCCH PF00642.24 CCF47998.1 - 8.2e-05 22.4 11.9 0.01 15.7 2.1 2.3 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) HBS1_N PF08938.10 CCF47998.1 - 0.0016 18.7 0.7 0.0044 17.3 0.0 2.0 2 0 0 2 2 2 1 HBS1 N-terminus Smr PF01713.21 CCF47998.1 - 0.0059 16.9 0.0 0.013 15.8 0.0 1.6 1 0 0 1 1 1 1 Smr domain zf-CCCH_3 PF15663.5 CCF47998.1 - 0.0077 16.4 6.4 0.087 13.0 6.5 2.1 1 1 1 2 2 2 2 Zinc-finger containing family zf_CCCH_4 PF18345.1 CCF47998.1 - 0.0086 16.1 11.0 0.64 10.1 1.9 3.0 2 2 0 2 2 2 2 Zinc finger domain zf-CCCH_4 PF18044.1 CCF47998.1 - 0.042 13.7 17.9 0.059 13.2 4.4 3.1 2 2 0 2 2 2 0 CCCH-type zinc finger LUC7 PF03194.15 CCF47998.1 - 0.11 12.1 2.2 0.71 9.5 0.0 2.9 3 1 1 4 4 4 0 LUC7 N_terminus Phage_integrase PF00589.22 CCF48001.1 - 0.1 12.4 0.0 0.25 11.1 0.0 1.6 1 1 1 2 2 2 0 Phage integrase family Popeye PF04831.13 CCF48003.1 - 0.0039 17.4 0.5 0.023 14.9 0.1 2.1 2 0 0 2 2 2 1 Popeye protein conserved region Humanin PF15040.6 CCF48003.1 - 1.2 8.6 3.6 2.2 7.8 3.6 1.4 1 0 0 1 1 1 0 Humanin family CRA PF06589.11 CCF48004.1 - 0.38 10.9 4.6 0.51 10.4 4.6 1.2 1 0 0 1 1 1 0 Circumsporozoite-related antigen (CRA) RVT_1 PF00078.27 CCF48006.1 - 1.9e-07 30.8 0.0 3e-07 30.2 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Phage_integrase PF00589.22 CCF48006.1 - 0.053 13.3 0.2 0.15 11.8 0.0 1.8 2 0 0 2 2 2 0 Phage integrase family zf-C2H2 PF00096.26 CCF48007.1 - 3.7e-06 27.1 12.0 0.00033 20.9 1.6 3.9 4 0 0 4 4 4 2 Zinc finger, C2H2 type DUF3268 PF11672.8 CCF48007.1 - 0.058 13.7 0.4 0.098 13.0 0.4 1.3 1 0 0 1 1 1 0 zinc-finger-containing domain TRAP_alpha PF03896.16 CCF48007.1 - 0.11 11.6 4.3 0.19 10.9 4.3 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit zf-C2H2_4 PF13894.6 CCF48007.1 - 0.99 10.4 20.2 0.25 12.3 3.1 3.5 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2HC_2 PF13913.6 CCF48007.1 - 2.4 8.2 7.3 3.3 7.7 0.6 2.4 2 0 0 2 2 2 0 zinc-finger of a C2HC-type NIF3 PF01784.18 CCF48008.1 - 1.7e-62 211.3 0.0 2.1e-62 211.0 0.0 1.0 1 0 0 1 1 1 1 NIF3 (NGG1p interacting factor 3) COPIIcoated_ERV PF07970.12 CCF48009.1 - 5.4e-39 134.3 1.0 9.6e-39 133.5 0.6 1.6 1 1 1 2 2 2 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 CCF48009.1 - 7.7e-27 93.5 0.1 1.5e-26 92.6 0.1 1.5 1 0 0 1 1 1 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) S1FA PF04689.13 CCF48009.1 - 3.5 7.8 5.6 2.3 8.4 2.5 2.0 2 0 0 2 2 2 0 DNA binding protein S1FA RNA_pol_A_bac PF01000.26 CCF48010.1 - 5.3e-28 97.6 0.0 9.6e-28 96.8 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 CCF48010.1 - 1.6e-20 72.3 0.0 2.3e-20 71.8 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Peptidase_C65 PF10275.9 CCF48011.1 - 1e-74 251.1 0.0 1.3e-74 250.8 0.0 1.1 1 0 0 1 1 1 1 Peptidase C65 Otubain OTU PF02338.19 CCF48011.1 - 0.034 14.6 0.0 0.78 10.2 0.0 2.3 1 1 0 1 1 1 0 OTU-like cysteine protease TetR_C_1 PF02909.17 CCF48011.1 - 0.078 12.8 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain Fungal_trans PF04082.18 CCF48012.1 - 2.3e-13 49.8 0.4 5.1e-13 48.7 0.4 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF48012.1 - 4.3e-05 23.6 11.0 6.7e-05 22.9 11.0 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Pyr_redox_2 PF07992.14 CCF48013.1 - 2.3e-66 224.0 8.9 2.3e-66 224.0 8.9 1.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 CCF48013.1 - 8.3e-42 141.9 2.4 1e-41 141.6 0.3 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 CCF48013.1 - 1.1e-19 70.8 10.3 4.7e-17 62.3 2.7 3.4 4 0 0 4 4 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CCF48013.1 - 6.4e-12 45.3 9.0 1.1e-09 38.0 0.6 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 CCF48013.1 - 1.5e-11 44.4 0.6 1.5e-11 44.4 0.6 3.0 2 1 1 3 3 3 1 FAD dependent oxidoreductase GIDA PF01134.22 CCF48013.1 - 7.7e-09 35.1 12.1 5.5e-07 29.0 6.5 3.0 2 1 0 2 2 2 2 Glucose inhibited division protein A FAD_binding_2 PF00890.24 CCF48013.1 - 2e-07 30.5 3.2 2e-07 30.5 3.2 3.9 2 1 1 3 3 3 1 FAD binding domain HI0933_like PF03486.14 CCF48013.1 - 4.8e-07 28.8 14.2 0.00035 19.4 1.5 4.1 4 0 0 4 4 4 2 HI0933-like protein NAD_binding_8 PF13450.6 CCF48013.1 - 7.6e-07 29.3 4.8 0.0003 20.9 0.6 2.5 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain AlaDh_PNT_C PF01262.21 CCF48013.1 - 8.8e-07 28.4 4.2 0.011 15.0 0.4 2.7 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain Thi4 PF01946.17 CCF48013.1 - 7e-06 25.5 4.4 0.00064 19.0 0.3 2.5 2 0 0 2 2 2 2 Thi4 family FAD_binding_3 PF01494.19 CCF48013.1 - 9.1e-06 25.1 11.2 0.021 14.1 1.2 3.6 3 1 0 3 3 3 2 FAD binding domain K_oxygenase PF13434.6 CCF48013.1 - 2e-05 23.9 1.8 0.096 11.8 0.1 2.7 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) DAO PF01266.24 CCF48013.1 - 0.0024 17.5 16.4 0.13 11.8 0.3 4.1 3 1 0 4 4 4 2 FAD dependent oxidoreductase Mqo PF06039.15 CCF48013.1 - 0.022 13.3 3.0 0.033 12.8 0.3 2.1 1 1 1 2 2 2 0 Malate:quinone oxidoreductase (Mqo) CsgF PF10614.9 CCF48013.1 - 0.052 13.8 0.1 0.1 12.8 0.1 1.4 1 0 0 1 1 1 0 Type VIII secretion system (T8SS), CsgF protein Lycopene_cycl PF05834.12 CCF48013.1 - 2.2 7.3 7.1 0.76 8.8 0.8 2.9 3 1 0 3 3 3 0 Lycopene cyclase protein 3HCDH_N PF02737.18 CCF48013.1 - 3.2 7.6 8.8 0.15 11.9 1.1 2.6 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain GluRS_N PF18466.1 CCF48013.1 - 4.6 7.7 6.9 3 8.3 0.5 3.4 4 0 0 4 4 4 0 Glutamate--tRNA ligase N-terminal domain DUF3506 PF12014.8 CCF48014.1 - 8.5e-12 45.3 0.0 2.5e-11 43.8 0.0 1.7 1 1 0 1 1 1 1 Domain of unknown function (DUF3506) F-box-like PF12937.7 CCF48014.1 - 8.7e-10 38.3 0.1 2e-09 37.2 0.1 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 CCF48014.1 - 4e-05 23.4 0.0 0.00011 21.9 0.0 1.8 1 0 0 1 1 1 1 F-box domain F-box_4 PF15966.5 CCF48014.1 - 0.00021 21.2 0.0 0.00037 20.4 0.0 1.4 1 0 0 1 1 1 1 F-box Aa_trans PF01490.18 CCF48015.1 - 1.7e-21 76.4 35.2 2.2e-21 76.1 35.2 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein DUF2368 PF10166.9 CCF48015.1 - 0.02 14.5 1.4 0.033 13.8 0.0 1.9 2 0 0 2 2 2 0 Uncharacterised conserved protein (DUF2368) Myb_DNA-bind_4 PF13837.6 CCF48016.1 - 0.014 15.8 2.0 0.021 15.2 0.7 2.0 2 0 0 2 2 2 0 Myb/SANT-like DNA-binding domain MADF_DNA_bdg PF10545.9 CCF48016.1 - 0.98 9.8 4.0 0.84 10.0 0.7 2.5 2 0 0 2 2 2 0 Alcohol dehydrogenase transcription factor Myb/SANT-like 60KD_IMP PF02096.20 CCF48017.1 - 7.9e-25 87.7 0.4 1.2e-24 87.1 0.4 1.3 1 0 0 1 1 1 1 60Kd inner membrane protein Membr_traf_MHD PF10540.9 CCF48018.1 - 3.3e-16 59.8 1.5 5.5e-07 29.9 0.5 3.2 1 1 1 2 2 2 2 Munc13 (mammalian uncoordinated) homology domain C2 PF00168.30 CCF48018.1 - 8.5e-10 38.9 0.0 1.8e-09 37.8 0.0 1.6 1 0 0 1 1 1 1 C2 domain DUF810 PF05664.11 CCF48018.1 - 8.7e-06 24.6 1.6 2e-05 23.4 0.2 2.2 2 0 0 2 2 2 1 Plant family of unknown function (DUF810) zf-NPL4 PF05020.15 CCF48018.1 - 0.047 13.8 0.2 0.21 11.7 0.0 2.1 2 0 0 2 2 2 0 NPL4 family, putative zinc binding region ATP-synt_E PF05680.12 CCF48018.1 - 0.28 11.5 2.9 1.7 9.0 0.1 2.9 2 0 0 2 2 2 0 ATP synthase E chain FlgN PF05130.12 CCF48019.1 - 0.047 14.2 0.5 0.16 12.5 0.2 1.8 2 0 0 2 2 2 0 FlgN protein Mus7 PF09462.10 CCF48020.1 - 4.4e-180 600.6 0.0 6.4e-180 600.0 0.0 1.3 1 0 0 1 1 1 1 Mus7/MMS22 family Sod_Fe_C PF02777.18 CCF48021.1 - 5.6e-34 116.4 0.1 9.5e-34 115.6 0.1 1.4 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.22 CCF48021.1 - 3.2e-31 107.6 4.0 3.7e-31 107.4 2.7 1.7 2 0 0 2 2 2 1 Iron/manganese superoxide dismutases, alpha-hairpin domain Adaptin_binding PF10199.9 CCF48022.1 - 3e-26 92.4 0.8 1.1e-25 90.5 0.8 2.0 1 1 0 1 1 1 1 Alpha and gamma adaptin binding protein p34 Lyase_1 PF00206.20 CCF48023.1 - 3.2e-23 82.6 0.0 4.9e-23 82.0 0.0 1.2 1 0 0 1 1 1 1 Lyase ADSL_C PF10397.9 CCF48023.1 - 3e-16 59.7 0.1 6.8e-16 58.6 0.1 1.7 1 0 0 1 1 1 1 Adenylosuccinate lyase C-terminus Adaptin_N PF01602.20 CCF48024.1 - 7.7e-141 470.2 7.6 1e-140 469.8 7.6 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 CCF48024.1 - 2.9e-62 209.5 1.2 1.7e-58 197.3 0.1 2.7 2 0 0 2 2 2 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 CCF48024.1 - 4.6e-17 62.2 5.4 7.4e-06 26.3 0.1 6.1 3 2 3 6 6 6 5 HEAT repeats HEAT PF02985.22 CCF48024.1 - 5.8e-11 41.7 0.4 0.0045 17.1 0.0 6.0 5 0 0 5 5 5 3 HEAT repeat Cnd3 PF12719.7 CCF48024.1 - 0.00023 20.5 0.3 0.088 12.0 0.4 2.7 2 0 0 2 2 2 2 Nuclear condensing complex subunits, C-term domain CLASP_N PF12348.8 CCF48024.1 - 0.0014 18.2 0.1 1.6 8.2 0.0 3.0 3 0 0 3 3 3 2 CLASP N terminal HEAT_EZ PF13513.6 CCF48024.1 - 0.0037 17.7 6.8 0.61 10.6 0.0 6.5 8 2 1 9 9 9 1 HEAT-like repeat Sec7_N PF12783.7 CCF48024.1 - 0.022 14.7 1.3 0.12 12.3 0.6 2.5 2 1 0 2 2 2 0 Guanine nucleotide exchange factor in Golgi transport N-terminal UNC45-central PF11701.8 CCF48024.1 - 0.1 12.6 0.1 12 5.8 0.0 2.9 2 1 0 2 2 2 0 Myosin-binding striated muscle assembly central RrnaAD PF00398.20 CCF48025.1 - 2e-60 204.1 0.0 2.7e-60 203.7 0.0 1.1 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_25 PF13649.6 CCF48025.1 - 3.4e-06 27.7 0.0 6.2e-06 26.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF48025.1 - 0.00016 22.2 0.0 0.00031 21.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CCF48025.1 - 0.0018 17.8 0.0 0.0028 17.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain CMAS PF02353.20 CCF48025.1 - 0.002 17.5 0.0 0.017 14.5 0.0 1.9 2 0 0 2 2 2 1 Mycolic acid cyclopropane synthetase Methyltransf_12 PF08242.12 CCF48025.1 - 0.0036 18.0 0.0 0.0067 17.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_2 PF00891.18 CCF48025.1 - 0.0053 16.1 0.0 0.009 15.3 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_23 PF13489.6 CCF48025.1 - 0.0068 16.2 0.0 0.011 15.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_28 PF02636.17 CCF48025.1 - 0.013 15.1 0.0 0.03 13.9 0.0 1.6 1 1 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase PCMT PF01135.19 CCF48025.1 - 0.014 15.1 0.0 0.022 14.5 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) NodS PF05401.11 CCF48025.1 - 0.032 13.9 0.0 0.053 13.1 0.0 1.3 1 0 0 1 1 1 0 Nodulation protein S (NodS) Ubie_methyltran PF01209.18 CCF48025.1 - 0.081 12.3 0.0 0.19 11.0 0.0 1.5 2 0 0 2 2 2 0 ubiE/COQ5 methyltransferase family Metallophos PF00149.28 CCF48026.1 - 1.1e-35 124.0 0.1 1.8e-35 123.3 0.1 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Glyco_hydro_65N PF03636.15 CCF48026.1 - 0.008 15.8 0.0 0.013 15.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 65, N-terminal domain STPPase_N PF16891.5 CCF48026.1 - 0.068 13.6 0.0 0.16 12.4 0.0 1.6 1 0 0 1 1 1 0 Serine-threonine protein phosphatase N-terminal domain RNA_pol_Rpb2_6 PF00562.28 CCF48027.1 - 4.2e-127 424.4 0.0 6.9e-127 423.7 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 CCF48027.1 - 1.7e-60 204.0 0.1 2.5e-60 203.5 0.1 1.2 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_2 PF04561.14 CCF48027.1 - 2.6e-35 121.8 0.6 5.1e-35 120.8 0.6 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_7 PF04560.20 CCF48027.1 - 5.5e-30 103.6 0.1 1.3e-29 102.5 0.1 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_4 PF04566.13 CCF48027.1 - 5.7e-27 93.8 0.7 1.8e-26 92.2 0.7 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_3 PF04565.16 CCF48027.1 - 4.9e-20 71.5 0.0 1e-19 70.4 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_5 PF04567.17 CCF48027.1 - 3.2e-11 43.6 0.1 8.8e-11 42.2 0.1 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 DUF5500 PF17604.2 CCF48027.1 - 0.16 12.1 0.1 0.54 10.4 0.1 1.9 1 0 0 1 1 1 0 Family of unknown function (DUF5500) Zn_clus PF00172.18 CCF48028.1 - 8.3e-09 35.4 12.7 1.5e-08 34.6 12.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PSI_integrin PF17205.3 CCF48028.1 - 0.012 15.4 0.8 0.022 14.5 0.8 1.4 1 0 0 1 1 1 0 Integrin plexin domain PET122 PF05476.11 CCF48028.1 - 0.23 10.7 0.0 0.63 9.3 0.1 1.6 2 0 0 2 2 2 0 PET122 EMC1_C PF07774.13 CCF48029.1 - 3.3e-62 209.9 0.0 6.6e-62 209.0 0.0 1.5 1 0 0 1 1 1 1 ER membrane protein complex subunit 1, C-terminal PQQ_2 PF13360.6 CCF48029.1 - 3.4e-10 39.9 3.5 7.9e-06 25.6 0.6 4.1 3 1 1 4 4 4 3 PQQ-like domain PQQ PF01011.21 CCF48029.1 - 1.1e-05 25.1 0.0 0.58 10.2 0.1 4.6 4 0 0 4 4 4 2 PQQ enzyme repeat PQQ_3 PF13570.6 CCF48029.1 - 0.36 11.4 3.1 16 6.2 0.0 4.8 5 0 0 5 5 5 0 PQQ-like domain HLH PF00010.26 CCF48030.1 - 9.9e-14 51.0 0.2 2.1e-13 50.0 0.2 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain TolA_bind_tri PF16331.5 CCF48030.1 - 0.036 14.1 3.5 0.12 12.5 3.5 1.8 1 0 0 1 1 1 0 TolA binding protein trimerisation PLC-beta_C PF08703.10 CCF48030.1 - 0.07 13.1 2.5 0.14 12.1 2.5 1.5 1 0 0 1 1 1 0 PLC-beta C terminal DUF4423 PF14394.6 CCF48030.1 - 0.2 11.4 1.1 0.26 11.0 0.1 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4423) eIF-5a PF01287.20 CCF48032.1 - 4.5e-31 106.8 0.6 6.3e-31 106.3 0.6 1.2 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold EFP_N PF08207.12 CCF48032.1 - 0.053 13.5 0.0 0.082 13.0 0.0 1.3 1 0 0 1 1 1 0 Elongation factor P (EF-P) KOW-like domain Dus PF01207.17 CCF48034.1 - 1.6e-44 152.3 0.0 1e-24 87.3 0.0 3.0 3 0 0 3 3 3 3 Dihydrouridine synthase (Dus) ASF1_hist_chap PF04729.13 CCF48035.1 - 1.5e-69 232.9 0.1 1.7e-69 232.7 0.1 1.0 1 0 0 1 1 1 1 ASF1 like histone chaperone RhoGEF PF00621.20 CCF48039.1 - 1.3e-37 129.8 0.0 2e-37 129.2 0.0 1.3 1 0 0 1 1 1 1 RhoGEF domain FYVE PF01363.21 CCF48039.1 - 5.4e-18 64.9 10.4 1.3e-17 63.6 10.4 1.7 1 0 0 1 1 1 1 FYVE zinc finger PH PF00169.29 CCF48039.1 - 4.3e-06 27.2 0.0 9.6e-05 22.9 0.0 2.4 2 0 0 2 2 2 1 PH domain PH_13 PF16652.5 CCF48039.1 - 0.0035 17.2 0.0 0.028 14.2 0.0 2.2 2 0 0 2 2 2 1 Pleckstrin homology domain FYVE_2 PF02318.16 CCF48039.1 - 0.74 10.0 7.2 1.7 8.8 7.2 1.6 1 0 0 1 1 1 0 FYVE-type zinc finger Spt20 PF12090.8 CCF48040.1 - 0.22 11.1 5.4 0.31 10.6 5.4 1.2 1 0 0 1 1 1 0 Spt20 family DASH_Spc19 PF08287.11 CCF48040.1 - 1.7 8.5 6.8 2.3 8.1 0.0 2.6 2 0 0 2 2 2 0 Spc19 Presenilin PF01080.17 CCF48040.1 - 2.7 6.7 4.8 3.1 6.5 4.8 1.2 1 0 0 1 1 1 0 Presenilin TMEM214 PF10151.9 CCF48040.1 - 9.6 4.5 8.3 15 3.9 8.3 1.2 1 0 0 1 1 1 0 TMEM214, C-terminal, caspase 4 activator RRM_1 PF00076.22 CCF48041.1 - 2.4e-30 104.2 0.0 3.1e-15 55.7 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CCF48041.1 - 1.1e-11 44.7 0.0 0.0001 22.3 0.0 2.7 2 0 0 2 2 2 2 RNA recognition motif GAD-like PF08887.11 CCF48041.1 - 0.049 13.4 0.3 0.11 12.3 0.3 1.4 1 0 0 1 1 1 0 GAD-like domain Nup35_RRM_2 PF14605.6 CCF48041.1 - 0.14 12.2 0.0 3.5 7.7 0.0 2.3 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif AAA PF00004.29 CCF48042.1 - 2.5e-60 202.7 0.0 1e-44 152.1 0.0 3.1 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 CCF48042.1 - 7.8e-10 39.4 0.2 0.008 16.6 0.0 3.9 3 0 0 3 3 3 2 AAA ATPase domain AAA_lid_3 PF17862.1 CCF48042.1 - 1.1e-05 25.2 2.0 0.15 11.9 0.1 3.2 3 0 0 3 3 3 2 AAA+ lid domain AAA_5 PF07728.14 CCF48042.1 - 1.1e-05 25.4 0.1 0.03 14.3 0.0 3.3 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 CCF48042.1 - 1.2e-05 25.1 0.0 0.0051 16.6 0.0 2.9 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 CCF48042.1 - 1.9e-05 25.2 0.1 0.032 14.8 0.0 3.2 3 0 0 3 3 2 1 AAA domain TsaE PF02367.17 CCF48042.1 - 0.0001 22.3 0.0 0.24 11.4 0.0 2.4 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_22 PF13401.6 CCF48042.1 - 0.00038 20.7 0.4 0.037 14.3 0.1 3.4 2 1 1 3 3 3 1 AAA domain Vps4_C PF09336.10 CCF48042.1 - 0.0008 19.3 0.0 0.01 15.8 0.0 2.5 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain DUF815 PF05673.13 CCF48042.1 - 0.0013 18.0 0.0 1.7 7.7 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF815) AAA_14 PF13173.6 CCF48042.1 - 0.0014 18.7 0.0 0.58 10.2 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 CCF48042.1 - 0.0019 18.4 0.1 0.43 10.7 0.0 3.1 3 0 0 3 3 2 1 AAA domain Sigma54_activat PF00158.26 CCF48042.1 - 0.0024 17.6 0.0 1.6 8.4 0.0 2.6 2 0 0 2 2 2 1 Sigma-54 interaction domain SKI PF01202.22 CCF48042.1 - 0.0026 17.9 0.2 0.18 11.9 0.0 2.7 2 0 0 2 2 2 1 Shikimate kinase AAA_25 PF13481.6 CCF48042.1 - 0.0026 17.4 0.3 0.013 15.1 0.0 2.3 2 1 0 2 2 2 1 AAA domain ATPase PF06745.13 CCF48042.1 - 0.0027 17.1 0.0 0.0066 15.8 0.0 1.6 1 0 0 1 1 1 1 KaiC AAA_2 PF07724.14 CCF48042.1 - 0.004 17.3 0.0 0.019 15.1 0.0 2.2 2 1 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_28 PF13521.6 CCF48042.1 - 0.0042 17.4 0.9 0.57 10.4 0.0 3.2 3 0 0 3 3 2 1 AAA domain TIP49 PF06068.13 CCF48042.1 - 0.0042 16.3 0.0 0.039 13.1 0.0 2.4 2 0 0 2 2 2 1 TIP49 P-loop domain IstB_IS21 PF01695.17 CCF48042.1 - 0.0042 16.8 0.0 0.012 15.3 0.0 1.7 2 0 0 2 2 1 1 IstB-like ATP binding protein Sigma54_activ_2 PF14532.6 CCF48042.1 - 0.0044 17.1 0.0 1.2 9.2 0.0 2.8 2 0 0 2 2 2 1 Sigma-54 interaction domain RNA_helicase PF00910.22 CCF48042.1 - 0.0076 16.6 0.0 0.095 13.1 0.0 2.5 2 0 0 2 2 2 1 RNA helicase Parvo_NS1 PF01057.17 CCF48042.1 - 0.0098 15.0 0.0 0.018 14.2 0.0 1.3 1 0 0 1 1 1 1 Parvovirus non-structural protein NS1 Mg_chelatase PF01078.21 CCF48042.1 - 0.014 14.7 0.4 0.056 12.8 0.1 2.1 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI Rad17 PF03215.15 CCF48042.1 - 0.016 15.1 0.0 0.63 9.9 0.0 2.3 2 0 0 2 2 2 0 Rad17 P-loop domain AAA_7 PF12775.7 CCF48042.1 - 0.024 14.1 0.0 0.12 11.9 0.0 2.0 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_3 PF07726.11 CCF48042.1 - 0.039 13.8 0.0 0.79 9.6 0.0 2.8 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) CDC48_2 PF02933.17 CCF48042.1 - 0.04 13.7 0.1 0.1 12.4 0.1 1.7 1 0 0 1 1 1 0 Cell division protein 48 (CDC48), domain 2 NACHT PF05729.12 CCF48042.1 - 0.063 13.2 1.0 4.1 7.3 0.1 3.3 3 0 0 3 3 3 0 NACHT domain PhoH PF02562.16 CCF48042.1 - 0.077 12.4 0.0 0.16 11.4 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein AAA_24 PF13479.6 CCF48042.1 - 0.096 12.4 0.1 0.24 11.1 0.1 1.6 1 0 0 1 1 1 0 AAA domain PH_10 PF15411.6 CCF48043.1 - 8.6e-40 135.8 0.4 1.9e-39 134.7 0.4 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain RhoGEF PF00621.20 CCF48043.1 - 1.1e-39 136.5 0.1 1.1e-39 136.5 0.1 1.6 2 0 0 2 2 2 1 RhoGEF domain CDC24 PF06395.11 CCF48043.1 - 1.8e-34 117.8 0.0 3.6e-34 116.9 0.0 1.5 1 0 0 1 1 1 1 CDC24 Calponin PB1 PF00564.24 CCF48043.1 - 3.5e-09 36.5 0.2 7.6e-09 35.4 0.2 1.6 1 0 0 1 1 1 1 PB1 domain CH PF00307.31 CCF48043.1 - 0.004 17.3 0.5 0.026 14.7 0.0 2.2 2 0 0 2 2 2 1 Calponin homology (CH) domain PH PF00169.29 CCF48043.1 - 0.16 12.5 0.2 0.4 11.2 0.2 1.7 1 1 0 1 1 1 0 PH domain 4HB_MCP_1 PF12729.7 CCF48043.1 - 6.7 6.2 8.0 1.2 8.7 1.7 2.6 3 0 0 3 3 3 0 Four helix bundle sensory module for signal transduction zf-RanBP PF00641.18 CCF48044.1 - 0.0074 15.6 2.0 0.017 14.5 2.0 1.5 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others Arteri_nucleo PF01481.16 CCF48045.1 - 0.097 13.0 0.3 0.097 13.0 0.3 2.0 2 1 0 3 3 3 0 Arterivirus nucleocapsid protein VWA_2 PF13519.6 CCF48046.1 - 2.2e-26 92.6 0.1 8.9e-26 90.6 0.1 2.1 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA PF00092.28 CCF48046.1 - 1.1e-10 42.0 0.2 2.3e-10 41.0 0.2 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain Ssl1 PF04056.14 CCF48046.1 - 2e-09 37.6 0.0 3.3e-09 36.8 0.0 1.3 1 0 0 1 1 1 1 Ssl1-like UIM PF02809.20 CCF48046.1 - 2.7e-06 26.9 34.8 9.3e-05 22.1 4.0 4.7 5 0 0 5 5 5 3 Ubiquitin interaction motif RAP80_UIM PF18282.1 CCF48046.1 - 0.03 14.1 8.9 0.46 10.3 0.2 3.4 3 0 0 3 3 3 0 RAP80 N-terminal ubiquitin interaction motif CAF1 PF04857.20 CCF48047.1 - 1.5e-21 76.9 0.0 1.8e-10 40.5 0.0 2.4 2 1 0 2 2 2 2 CAF1 family ribonuclease UQ_con PF00179.26 CCF48048.1 - 6e-46 155.6 0.0 6.9e-46 155.4 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 CCF48048.1 - 0.009 15.7 0.0 0.014 15.1 0.0 1.3 1 1 0 1 1 1 1 Prokaryotic E2 family B ANAPC1 PF12859.7 CCF48049.1 - 1.2e-17 64.7 0.9 6.8e-17 62.2 0.1 2.8 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 1 APC1_C PF18122.1 CCF48049.1 - 1.2e-08 35.1 0.0 2.5e-08 34.0 0.0 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex sub unit 1 C-terminal domain PC_rep PF01851.22 CCF48049.1 - 3.8e-06 27.1 16.2 0.69 10.5 0.2 6.1 6 0 0 6 6 6 4 Proteasome/cyclosome repeat Thioredoxin PF00085.20 CCF48050.1 - 6.3e-60 199.6 0.7 4.2e-31 107.0 0.1 3.7 4 0 0 4 4 4 2 Thioredoxin Thioredoxin_6 PF13848.6 CCF48050.1 - 2.7e-36 125.2 2.0 3.6e-27 95.5 0.4 3.1 2 1 1 3 3 3 2 Thioredoxin-like domain Thioredoxin_2 PF13098.6 CCF48050.1 - 5.9e-10 39.6 0.3 0.0046 17.4 0.0 3.9 3 2 0 3 3 3 2 Thioredoxin-like domain Calsequestrin PF01216.17 CCF48050.1 - 1e-09 38.0 2.1 1.6e-09 37.3 2.1 1.2 1 0 0 1 1 1 1 Calsequestrin Thioredoxin_7 PF13899.6 CCF48050.1 - 8.4e-08 32.3 0.0 0.0017 18.5 0.0 3.0 2 0 0 2 2 2 2 Thioredoxin-like Thioredoxin_8 PF13905.6 CCF48050.1 - 4.3e-07 30.2 0.2 0.11 12.8 0.0 4.5 5 1 1 6 6 5 2 Thioredoxin-like OST3_OST6 PF04756.13 CCF48050.1 - 1.2e-05 24.8 0.4 0.035 13.5 0.0 2.6 3 0 0 3 3 3 2 OST3 / OST6 family, transporter family AhpC-TSA PF00578.21 CCF48050.1 - 1.8e-05 24.6 0.5 0.31 11.0 0.0 2.9 3 0 0 3 3 3 2 AhpC/TSA family Redoxin PF08534.10 CCF48050.1 - 0.0011 18.7 3.5 0.21 11.3 0.0 3.2 3 0 0 3 3 3 1 Redoxin TraF PF13728.6 CCF48050.1 - 0.0018 18.1 0.0 0.056 13.3 0.0 2.7 2 1 0 2 2 2 1 F plasmid transfer operon protein Thioredoxin_4 PF13462.6 CCF48050.1 - 0.0063 16.7 0.6 3.3 7.8 0.0 3.0 2 1 0 2 2 2 2 Thioredoxin Thioredoxin_3 PF13192.6 CCF48050.1 - 0.069 13.2 0.0 2.6 8.2 0.0 2.5 2 0 0 2 2 2 0 Thioredoxin domain LAT PF15234.6 CCF48050.1 - 0.1 12.3 0.1 8.3 6.1 0.0 2.3 2 0 0 2 2 2 0 Linker for activation of T-cells EF1G PF00647.19 CCF48051.1 - 1.3e-45 153.8 0.1 2.4e-45 153.0 0.1 1.5 1 0 0 1 1 1 1 Elongation factor 1 gamma, conserved domain GST_N PF02798.20 CCF48051.1 - 5e-15 55.6 0.0 1.6e-14 54.0 0.0 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 CCF48051.1 - 2e-11 43.9 0.0 6.4e-11 42.3 0.0 1.9 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 CCF48051.1 - 1.3e-08 34.7 0.0 5.1e-08 32.8 0.0 2.0 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 CCF48051.1 - 4.3e-07 30.1 0.1 2.3e-06 27.7 0.0 2.1 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 CCF48051.1 - 5e-07 30.0 0.0 1e-06 29.1 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 CCF48051.1 - 5.8e-05 23.3 0.0 0.00013 22.2 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain OAD_gamma PF04277.13 CCF48051.1 - 4.7 7.9 5.4 11 6.7 5.4 1.6 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain CPDase PF07823.11 CCF48052.1 - 1.2e-15 57.8 0.0 1.4e-15 57.5 0.0 1.1 1 0 0 1 1 1 1 Cyclic phosphodiesterase-like protein 2_5_RNA_ligase2 PF13563.6 CCF48052.1 - 0.002 18.1 0.0 0.0026 17.7 0.0 1.3 1 0 0 1 1 1 1 2'-5' RNA ligase superfamily Sde2_N_Ubi PF13019.6 CCF48052.1 - 0.086 12.7 0.2 0.14 12.0 0.2 1.3 1 0 0 1 1 1 0 Silencing defective 2 N-terminal ubiquitin domain ubiquitin PF00240.23 CCF48053.1 - 1.5e-34 117.6 0.5 1.9e-34 117.2 0.5 1.2 1 0 0 1 1 1 1 Ubiquitin family Ribosomal_L40e PF01020.17 CCF48053.1 - 2.4e-30 104.2 9.4 3.6e-30 103.6 9.4 1.3 1 0 0 1 1 1 1 Ribosomal L40e family Rad60-SLD PF11976.8 CCF48053.1 - 3.2e-16 58.9 0.6 4.5e-16 58.4 0.6 1.2 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 CCF48053.1 - 2.1e-05 24.9 0.1 7.7e-05 23.1 0.1 1.8 1 1 0 1 1 1 1 Ubiquitin-like domain TBK1_ULD PF18396.1 CCF48053.1 - 0.0049 16.8 0.0 0.0063 16.4 0.0 1.3 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_5 PF18037.1 CCF48053.1 - 0.0056 17.0 0.0 0.0084 16.4 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 CCF48053.1 - 0.008 16.3 0.0 0.019 15.0 0.0 1.6 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_4 PF18036.1 CCF48053.1 - 0.014 15.4 1.1 4 7.5 0.2 2.2 2 0 0 2 2 2 0 Ubiquitin-like domain DUF2407 PF10302.9 CCF48053.1 - 0.029 14.9 0.0 0.037 14.6 0.0 1.3 1 1 0 1 1 1 0 DUF2407 ubiquitin-like domain zf-C2H2_2 PF12756.7 CCF48054.1 - 6.2e-36 122.8 6.7 2.8e-28 98.2 0.1 3.4 2 1 1 3 3 3 2 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.8 CCF48054.1 - 1.3e-13 50.8 15.3 1.5e-09 37.9 3.5 5.0 4 1 0 4 4 4 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 CCF48054.1 - 5.5e-10 39.3 4.9 5e-09 36.3 2.5 2.7 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.6 CCF48054.1 - 2.1e-06 28.1 11.2 0.11 13.4 0.1 4.8 4 0 0 4 4 4 2 C2H2-type zinc finger zf-C2H2 PF00096.26 CCF48054.1 - 0.0018 18.6 16.4 0.16 12.5 0.6 4.4 4 1 0 4 4 4 2 Zinc finger, C2H2 type zf-DBF PF07535.12 CCF48054.1 - 0.017 15.2 3.9 0.024 14.7 0.8 2.7 2 0 0 2 2 2 0 DBF zinc finger AKAP95 PF04988.12 CCF48054.1 - 0.051 13.8 1.6 12 6.1 0.1 2.6 1 1 1 2 2 2 0 A-kinase anchoring protein 95 (AKAP95) zf-H2C2_2 PF13465.6 CCF48054.1 - 0.078 13.4 8.1 1.3 9.6 0.0 4.1 4 0 0 4 4 4 0 Zinc-finger double domain zf-C2H2_8 PF15909.5 CCF48054.1 - 0.08 13.2 1.0 0.2 11.9 1.0 1.7 1 0 0 1 1 1 0 C2H2-type zinc ribbon ARS2 PF04959.13 CCF48054.1 - 0.12 12.7 6.2 0.89 9.9 0.2 3.0 3 1 0 3 3 3 0 Arsenite-resistance protein 2 CAF1A PF12253.8 CCF48054.1 - 0.46 10.7 7.5 1.3 9.2 7.5 1.8 1 0 0 1 1 1 0 Chromatin assembly factor 1 subunit A HNH_5 PF14279.6 CCF48054.1 - 1.6 8.7 4.4 11 6.0 0.2 3.4 3 0 0 3 3 3 0 HNH endonuclease zf-LYAR PF08790.11 CCF48054.1 - 6.3 6.8 5.8 5.8 6.9 0.1 3.2 3 0 0 3 3 3 0 LYAR-type C2HC zinc finger DENN PF02141.21 CCF48055.1 - 0.056 13.4 2.3 0.88 9.5 0.2 2.4 2 0 0 2 2 2 0 DENN (AEX-3) domain Complex1_LYR PF05347.15 CCF48056.1 - 3.3e-06 27.1 0.3 5.6e-06 26.3 0.3 1.4 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 CCF48056.1 - 1.1e-05 26.1 0.0 1.5e-05 25.6 0.0 1.3 1 0 0 1 1 1 1 Complex1_LYR-like SUIM_assoc PF16619.5 CCF48056.1 - 0.011 15.7 0.1 0.043 13.9 0.1 1.8 1 1 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 PhoLip_ATPase_C PF16212.5 CCF48057.1 - 5.1e-51 173.8 20.6 5.1e-51 173.8 20.6 2.1 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 CCF48057.1 - 3.9e-19 68.1 3.0 9.2e-19 66.9 3.0 1.6 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.26 CCF48057.1 - 7.2e-13 49.3 1.8 1.4e-09 38.5 1.8 3.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 CCF48057.1 - 2.9e-08 33.7 0.0 6.8e-07 29.3 0.0 2.4 2 0 0 2 2 2 1 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.20 CCF48057.1 - 8.1e-08 32.0 13.0 0.00033 20.2 0.5 3.3 3 0 0 3 3 3 2 E1-E2 ATPase Hydrolase_3 PF08282.12 CCF48057.1 - 0.011 15.4 0.0 0.028 14.2 0.0 1.6 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase Peptidase_M3 PF01432.20 CCF48058.1 - 2.2e-117 393.1 0.0 3.1e-117 392.7 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M3 DUF4344 PF14247.6 CCF48058.1 - 0.28 10.8 1.3 34 4.0 1.2 2.7 3 0 0 3 3 3 0 Putative metallopeptidase rve PF00665.26 CCF48061.1 - 1.1e-10 41.7 0.0 1.8e-10 41.0 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain gag_pre-integrs PF13976.6 CCF48061.1 - 0.0042 16.9 0.0 0.012 15.5 0.0 1.8 1 0 0 1 1 1 1 GAG-pre-integrase domain rve_3 PF13683.6 CCF48061.1 - 0.0085 15.9 0.0 0.018 14.8 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 CCF48061.1 - 0.11 12.7 0.1 0.36 11.0 0.1 1.8 1 0 0 1 1 1 0 Integrase zinc binding domain MFS_1 PF07690.16 CCF48062.1 - 1.4e-28 99.9 45.2 1.4e-28 99.9 45.2 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily OATP PF03137.20 CCF48062.1 - 0.0028 16.0 8.9 0.052 11.8 3.1 3.6 2 2 2 4 4 4 2 Organic Anion Transporter Polypeptide (OATP) family Presenilin PF01080.17 CCF48062.1 - 0.12 11.1 0.8 4.1 6.1 0.0 2.5 2 0 0 2 2 2 0 Presenilin Tis11B_N PF04553.12 CCF48062.1 - 0.15 12.6 1.1 0.29 11.7 1.1 1.3 1 0 0 1 1 1 0 Tis11B like protein, N terminus Lipase_3 PF01764.25 CCF48063.1 - 3.2e-15 56.3 0.0 6e-15 55.3 0.0 1.4 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_6 PF12697.7 CCF48063.1 - 0.022 15.4 2.9 0.028 15.0 0.3 2.3 2 1 0 2 2 2 0 Alpha/beta hydrolase family Myb_DNA-bind_5 PF13873.6 CCF48064.1 - 0.00038 20.5 2.6 0.00084 19.4 2.6 1.5 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain DDE_Tnp_4 PF13359.6 CCF48065.1 - 4.4e-12 46.0 0.0 4.3e-11 42.7 0.0 2.1 2 0 0 2 2 2 1 DDE superfamily endonuclease ABC1 PF03109.16 CCF48066.1 - 2.4e-28 98.7 0.0 7.5e-28 97.1 0.0 1.8 2 0 0 2 2 2 1 ABC1 family Oxidored-like PF09791.9 CCF48066.1 - 5e-18 64.5 0.7 5e-18 64.5 0.7 2.1 2 0 0 2 2 2 1 Oxidoreductase-like protein, N-terminal Pkinase PF00069.25 CCF48066.1 - 0.14 11.5 0.0 0.24 10.7 0.0 1.3 1 0 0 1 1 1 0 Protein kinase domain DUF5522 PF17653.1 CCF48066.1 - 0.51 10.3 4.3 1.1 9.3 4.3 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5522) Mid1 PF12929.7 CCF48067.1 - 1e-72 245.7 1.8 1.3e-72 245.3 1.8 1.1 1 0 0 1 1 1 1 Stretch-activated Ca2+-permeable channel component DUF1180 PF06679.12 CCF48067.1 - 0.0015 18.9 0.2 0.0057 17.1 0.2 2.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1180) Fz PF01392.22 CCF48067.1 - 0.0074 16.9 6.1 0.011 16.4 1.4 2.7 3 0 0 3 3 3 1 Fz domain fn3 PF00041.21 CCF48067.1 - 0.035 14.4 0.2 0.42 11.0 0.0 2.4 2 0 0 2 2 2 0 Fibronectin type III domain Hep_59 PF07052.11 CCF48068.1 - 1.2e-24 87.1 0.3 2.6e-24 86.0 0.0 1.6 2 0 0 2 2 2 1 Hepatocellular carcinoma-associated antigen 59 BORCS6 PF10157.9 CCF48068.1 - 0.00055 20.2 0.3 0.0011 19.3 0.3 1.5 1 0 0 1 1 1 1 BLOC-1-related complex sub-unit 6 SR-25 PF10500.9 CCF48068.1 - 0.25 10.9 9.1 0.028 14.0 4.3 1.9 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein IMUP PF15761.5 CCF48068.1 - 9.7 6.9 11.2 12 6.6 9.3 2.1 1 1 1 2 2 2 0 Immortalisation up-regulated protein Glutaredoxin PF00462.24 CCF48069.1 - 1.4e-08 34.8 0.0 1.9e-08 34.4 0.0 1.1 1 0 0 1 1 1 1 Glutaredoxin GST_N_2 PF13409.6 CCF48069.1 - 0.0098 16.2 0.0 0.012 15.9 0.0 1.1 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 CCF48069.1 - 0.026 14.9 0.0 0.033 14.6 0.0 1.1 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain rve PF00665.26 CCF48070.1 - 1.9e-08 34.5 0.0 3.8e-08 33.5 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 CCF48070.1 - 0.00015 21.8 0.0 0.00037 20.6 0.0 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain Asp_protease_2 PF13650.6 CCF48071.1 - 0.04 14.6 0.0 0.1 13.3 0.0 1.6 1 0 0 1 1 1 0 Aspartyl protease gag-asp_proteas PF13975.6 CCF48071.1 - 0.094 13.3 0.0 0.35 11.5 0.0 2.1 1 1 0 1 1 1 0 gag-polyprotein putative aspartyl protease rve PF00665.26 CCF48075.1 - 0.0013 18.9 0.0 0.0021 18.2 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain RRM_1 PF00076.22 CCF48076.1 - 2.8e-16 59.1 0.3 4.4e-09 36.0 0.2 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 CCF48076.1 - 0.0011 18.6 0.0 0.087 12.4 0.0 2.3 1 1 1 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 CCF48076.1 - 0.03 14.3 0.1 0.56 10.3 0.0 2.2 2 0 0 2 2 2 0 RNA binding motif Nup35_RRM_2 PF14605.6 CCF48076.1 - 0.11 12.6 0.3 11 6.1 0.0 2.3 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif RVT_2 PF07727.14 CCF48078.1 - 8.1e-33 114.1 0.0 9.2e-33 113.9 0.0 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Arm-DNA-bind_4 PF14657.6 CCF48079.1 - 0.0043 16.8 0.5 0.0077 16.0 0.5 1.4 1 0 0 1 1 1 1 Arm DNA-binding domain Hfq PF17209.3 CCF48082.1 - 0.017 14.7 0.1 0.027 14.1 0.1 1.3 1 0 0 1 1 1 0 Hfq protein CX9C PF16860.5 CCF48086.1 - 5.5e-06 26.3 4.9 0.023 14.7 1.7 2.1 1 1 1 2 2 2 2 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, UPF0203 PF05254.12 CCF48086.1 - 0.0046 17.2 3.6 0.065 13.5 3.6 2.0 1 1 0 1 1 1 1 Uncharacterised protein family (UPF0203) CHCH PF06747.13 CCF48086.1 - 0.021 15.0 1.9 0.058 13.5 1.8 1.8 1 1 0 1 1 1 0 CHCH domain Abhydrolase_1 PF00561.20 CCF48087.1 - 3.8e-08 33.3 0.0 8.7e-07 28.8 0.0 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CCF48087.1 - 0.014 14.7 0.0 3.2 6.9 0.0 2.4 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Pan3_PK PF18101.1 CCF48088.1 - 4.9e-63 211.2 0.2 7.2e-63 210.7 0.2 1.2 1 0 0 1 1 1 1 Pan3 Pseudokinase domain Pkinase PF00069.25 CCF48088.1 - 0.14 11.5 0.0 0.29 10.5 0.0 1.4 1 0 0 1 1 1 0 Protein kinase domain zf-CCCH PF00642.24 CCF48088.1 - 0.38 10.7 2.4 1.2 9.1 2.4 2.0 1 1 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) SRI PF08236.11 CCF48089.1 - 1.6e-21 76.3 1.7 4.1e-21 75.0 1.7 1.8 1 0 0 1 1 1 1 SRI (Set2 Rpb1 interacting) domain SET PF00856.28 CCF48089.1 - 2e-20 73.8 0.1 2e-20 73.8 0.1 2.9 3 1 0 3 3 3 1 SET domain AWS PF17907.1 CCF48089.1 - 6.2e-12 45.3 4.4 6.2e-12 45.3 4.4 2.1 2 0 0 2 2 2 1 AWS domain RAB3GAP2_N PF14655.6 CCF48089.1 - 0.09 12.0 0.4 0.16 11.2 0.4 1.3 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus WD40 PF00400.32 CCF48090.1 - 1.1e-10 41.9 2.8 0.00034 21.3 0.0 4.8 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF48090.1 - 4.1e-10 39.8 0.0 0.14 12.5 0.0 4.3 2 2 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 CCF48090.1 - 0.028 14.3 0.7 12 6.0 0.0 3.1 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat Ge1_WD40 PF16529.5 CCF48090.1 - 0.042 12.8 0.2 0.29 10.0 0.0 2.4 3 0 0 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein MoCF_biosynth PF00994.24 CCF48090.1 - 0.073 12.7 0.0 0.14 11.8 0.0 1.4 1 0 0 1 1 1 0 Probable molybdopterin binding domain FA_desaturase PF00487.24 CCF48091.1 - 3.6e-26 92.5 20.6 3.6e-26 92.5 20.6 1.7 2 0 0 2 2 2 1 Fatty acid desaturase Cyt-b5 PF00173.28 CCF48091.1 - 1.2e-13 51.0 0.0 2.6e-13 49.9 0.0 1.6 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Amidohydro_3 PF07969.11 CCF48093.1 - 2.1e-75 255.0 0.4 3.1e-75 254.5 0.4 1.2 1 0 0 1 1 1 1 Amidohydrolase family Methyltransf_23 PF13489.6 CCF48093.1 - 5.2e-08 32.9 0.0 1e-07 32.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Amidohydro_1 PF01979.20 CCF48093.1 - 1.2e-06 28.1 0.0 1.1e-05 24.9 0.0 2.3 2 1 0 2 2 2 1 Amidohydrolase family Methyltransf_12 PF08242.12 CCF48093.1 - 2.2e-06 28.3 0.0 4.7e-06 27.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF48093.1 - 7.7e-06 26.5 0.0 1.7e-05 25.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF48093.1 - 8.5e-05 22.4 0.0 0.00058 19.7 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 CCF48093.1 - 0.00035 20.0 0.0 0.00068 19.0 0.0 1.4 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_11 PF08241.12 CCF48093.1 - 0.00058 20.5 0.0 0.0017 18.9 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CCF48093.1 - 0.019 14.5 0.0 0.043 13.4 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase small domain PCMT PF01135.19 CCF48093.1 - 0.071 12.9 0.0 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) RrnaAD PF00398.20 CCF48093.1 - 0.13 11.3 0.0 0.21 10.6 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase PCI PF01399.27 CCF48094.1 - 2.6e-10 40.7 0.0 6.3e-10 39.5 0.0 1.7 1 0 0 1 1 1 1 PCI domain Exonuc_V_gamma PF04257.14 CCF48094.1 - 0.029 12.6 0.1 0.056 11.7 0.1 1.4 1 0 0 1 1 1 0 Exodeoxyribonuclease V, gamma subunit Ras PF00071.22 CCF48095.1 - 2e-51 173.8 0.0 2.4e-51 173.6 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CCF48095.1 - 3.3e-23 82.2 0.0 6.7e-23 81.2 0.0 1.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CCF48095.1 - 3.6e-06 26.6 0.0 5.2e-06 26.0 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 CCF48095.1 - 0.0086 15.6 0.0 0.02 14.4 0.0 1.5 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain PduV-EutP PF10662.9 CCF48095.1 - 0.028 14.2 0.0 10 5.9 0.0 2.6 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation AAA_16 PF13191.6 CCF48095.1 - 0.037 14.4 0.1 0.097 13.0 0.1 2.0 1 1 0 1 1 1 0 AAA ATPase domain SRPRB PF09439.10 CCF48095.1 - 0.13 11.7 0.0 0.2 11.1 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit RNA_pol PF00940.19 CCF48096.1 - 1.8e-176 587.0 0.0 4.2e-176 585.8 0.0 1.6 2 0 0 2 2 2 1 DNA-dependent RNA polymerase RPOL_N PF14700.6 CCF48096.1 - 8.7e-96 321.2 2.0 8.7e-96 321.2 2.0 1.7 2 0 0 2 2 2 1 DNA-directed RNA polymerase N-terminal PPR_2 PF13041.6 CCF48096.1 - 0.0017 18.5 0.0 0.012 15.7 0.0 2.4 2 0 0 2 2 2 1 PPR repeat family SbcD_C PF12320.8 CCF48096.1 - 0.048 13.9 0.0 0.21 11.9 0.0 2.1 1 0 0 1 1 1 0 Type 5 capsule protein repressor C-terminal domain DNA_pol_B_palm PF14792.6 CCF48096.1 - 0.13 12.5 0.0 0.84 9.9 0.0 2.3 3 0 0 3 3 3 0 DNA polymerase beta palm TauD PF02668.16 CCF48097.1 - 4.1e-25 89.1 0.6 1.1e-24 87.7 0.6 1.7 1 1 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family Gp_dh_C PF02800.20 CCF48098.1 - 5.3e-72 240.6 0.0 7.6e-72 240.1 0.0 1.2 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.24 CCF48098.1 - 4.9e-38 129.5 0.2 9.7e-38 128.6 0.2 1.5 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain Chromo PF00385.24 CCF48100.1 - 8.1e-12 44.9 0.1 1.2e-11 44.4 0.1 1.2 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain WHAMM-JMY_N PF15920.5 CCF48101.1 - 0.23 11.3 3.0 3.4 7.6 0.1 2.7 3 0 0 3 3 3 0 N-terminal of Junction-mediating and WASP homolog-associated RVT_2 PF07727.14 CCF48103.1 - 1.6e-22 80.4 0.0 9.2e-22 77.9 0.0 1.8 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_2 PF07727.14 CCF48104.1 - 8.1e-31 107.5 0.0 1.1e-30 107.0 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.27 CCF48104.1 - 0.09 12.3 0.0 0.25 10.8 0.0 1.7 1 1 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) Dicty_REP PF05086.12 CCF48105.1 - 0.75 7.7 4.5 0.74 7.7 4.5 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein zf-CCHC PF00098.23 CCF48105.1 - 4.8 7.4 6.0 0.63 10.2 1.8 1.7 2 0 0 2 2 2 0 Zinc knuckle Pkinase PF00069.25 CCF48107.1 - 1.4e-73 247.5 0.1 1.4e-73 247.5 0.1 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF48107.1 - 5.9e-52 176.5 0.1 5.9e-52 176.5 0.1 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase PBD PF00786.28 CCF48107.1 - 9.3e-23 80.4 0.0 2.2e-22 79.1 0.0 1.7 1 0 0 1 1 1 1 P21-Rho-binding domain PH PF00169.29 CCF48107.1 - 5.7e-12 46.1 1.0 1.1e-11 45.1 1.0 1.5 1 0 0 1 1 1 1 PH domain Pkinase_fungal PF17667.1 CCF48107.1 - 1.2e-06 27.6 0.1 2.5e-06 26.5 0.1 1.6 1 1 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 CCF48107.1 - 2.7e-06 26.9 0.0 4.9e-06 26.1 0.0 1.4 1 0 0 1 1 1 1 Kinase-like PH_11 PF15413.6 CCF48107.1 - 0.0013 19.1 1.6 0.042 14.3 1.6 2.7 1 1 0 1 1 1 1 Pleckstrin homology domain Haspin_kinase PF12330.8 CCF48107.1 - 0.0032 16.5 0.0 0.0062 15.5 0.0 1.4 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 CCF48107.1 - 0.0089 16.0 0.0 0.031 14.2 0.0 1.7 1 1 1 2 2 2 1 Phosphotransferase enzyme family GW PF13457.6 CCF48107.1 - 0.11 13.1 0.0 0.37 11.4 0.0 1.9 1 0 0 1 1 1 0 GW (Gly-Tryp) dipeptide domain Sen15 PF09631.10 CCF48108.1 - 2.5e-11 43.8 0.0 4.6e-11 42.9 0.0 1.4 1 0 0 1 1 1 1 Sen15 protein Stealth_CR2 PF11380.8 CCF48110.1 - 4.9e-15 55.6 0.1 1.5e-08 34.8 0.1 3.9 4 0 0 4 4 4 2 Stealth protein CR2, conserved region 2 Stealth_CR4 PF17103.5 CCF48110.1 - 0.00023 21.0 0.0 0.00073 19.4 0.0 1.9 1 0 0 1 1 1 1 Stealth protein CR4, conserved region 4 Stealth_CR3 PF17102.5 CCF48110.1 - 0.0037 17.1 0.1 0.013 15.3 0.0 2.0 2 0 0 2 2 2 1 Stealth protein CR3, conserved region 3 EF-hand_1 PF00036.32 CCF48110.1 - 0.0071 15.8 0.0 0.021 14.4 0.0 1.8 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 CCF48110.1 - 0.012 15.5 0.0 0.039 13.9 0.0 1.9 1 0 0 1 1 1 0 EF-hand domain Stealth_CR1 PF17101.5 CCF48110.1 - 0.014 15.1 0.1 0.029 14.1 0.1 1.6 1 0 0 1 1 1 0 Stealth protein CR1, conserved region 1 Pkinase PF00069.25 CCF48111.1 - 2.1e-39 135.5 0.0 5.7e-38 130.8 0.0 2.4 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF48111.1 - 4.7e-24 85.1 0.0 1.1e-23 83.9 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCF48111.1 - 0.0011 18.4 0.0 0.002 17.5 0.0 1.4 1 0 0 1 1 1 1 Kinase-like DUF1682 PF07946.14 CCF48111.1 - 1.6 7.8 7.3 3.1 6.9 4.8 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1682) RPA_interact_C PF14768.6 CCF48114.1 - 0.0032 18.0 0.5 0.0054 17.3 0.5 1.3 1 0 0 1 1 1 1 Replication protein A interacting C-terminal zinc_ribbon_5 PF13719.6 CCF48114.1 - 0.14 11.9 0.2 1.9 8.3 0.0 2.2 2 0 0 2 2 2 0 zinc-ribbon domain RRM_1 PF00076.22 CCF48115.1 - 1.9e-22 78.8 0.0 2.7e-22 78.3 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CCF48115.1 - 0.0081 16.3 0.0 0.013 15.7 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif Glyoxal_oxid_N PF07250.11 CCF48116.1 - 3.5e-28 98.4 1.9 6.3e-22 77.9 2.0 4.9 2 2 1 3 3 3 1 Glyoxal oxidase N-terminus DUF1929 PF09118.11 CCF48116.1 - 2.3e-19 69.5 0.2 6e-19 68.1 0.2 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF1929) DUF444 PF04285.12 CCF48117.1 - 0.028 13.5 0.1 4.3 6.3 0.1 2.0 1 1 0 2 2 2 0 Protein of unknown function (DUF444) Ribosomal_L11_N PF03946.14 CCF48118.1 - 2.3e-24 85.0 0.1 3.7e-24 84.3 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Ribosomal_L11 PF00298.19 CCF48118.1 - 2.3e-17 63.3 0.2 4e-17 62.5 0.2 1.4 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain HnRNP_M PF11532.8 CCF48118.1 - 0.0087 16.3 0.8 0.015 15.5 0.8 1.3 1 0 0 1 1 1 1 Heterogeneous nuclear ribonucleoprotein M WD40 PF00400.32 CCF48119.1 - 4.6e-42 141.2 21.9 3.8e-08 33.8 0.1 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF48119.1 - 3.7e-10 40.0 0.6 0.025 14.9 0.0 4.8 1 1 3 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 CCF48119.1 - 1.2e-05 24.2 7.1 0.023 13.4 0.3 4.0 2 1 2 4 4 4 3 Nucleoporin Nup120/160 PD40 PF07676.12 CCF48119.1 - 0.012 15.5 1.3 22 5.1 0.0 4.6 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat JUPITER PF17054.5 CCF48119.1 - 0.17 11.3 0.0 0.22 10.9 0.0 1.1 1 0 0 1 1 1 0 Microtubule-Associated protein Jupiter Thymidylat_synt PF00303.19 CCF48120.1 - 3.9e-108 360.6 0.0 5.9e-108 360.0 0.0 1.3 1 0 0 1 1 1 1 Thymidylate synthase His_Phos_1 PF00300.22 CCF48120.1 - 1.2e-37 129.5 0.0 4e-37 127.8 0.0 1.8 2 0 0 2 2 2 1 Histidine phosphatase superfamily (branch 1) Sec23_trunk PF04811.15 CCF48121.1 - 1.5e-57 194.9 0.0 5.1e-57 193.2 0.0 1.8 1 1 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.15 CCF48121.1 - 1e-21 76.7 0.0 1.8e-21 75.9 0.0 1.4 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Sec23_BS PF08033.12 CCF48121.1 - 1.7e-19 70.3 0.0 3.9e-19 69.2 0.0 1.6 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.15 CCF48121.1 - 1.8e-14 53.5 2.3 3.6e-14 52.5 2.3 1.5 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 CCF48121.1 - 0.00044 20.1 0.0 0.0011 18.8 0.0 1.6 1 0 0 1 1 1 1 Gelsolin repeat FUSC PF04632.12 CCF48121.1 - 1.2 7.5 4.6 2.5 6.5 4.6 1.4 1 0 0 1 1 1 0 Fusaric acid resistance protein family peroxidase PF00141.23 CCF48122.1 - 2.2e-47 161.7 0.0 3.7e-47 160.9 0.0 1.4 1 0 0 1 1 1 1 Peroxidase COX_ARM PF06481.14 CCF48122.1 - 0.22 11.5 0.1 0.22 11.5 0.1 2.9 3 0 0 3 3 3 0 COX Aromatic Rich Motif IGPS PF00218.21 CCF48123.1 - 2.1e-91 305.6 0.0 7.8e-90 300.5 0.0 2.2 2 0 0 2 2 2 1 Indole-3-glycerol phosphate synthase PRAI PF00697.22 CCF48123.1 - 3.6e-47 160.7 0.0 6.9e-41 140.2 0.0 2.3 1 1 1 2 2 2 2 N-(5'phosphoribosyl)anthranilate (PRA) isomerase GATase PF00117.28 CCF48123.1 - 1.9e-41 141.9 0.0 3.3e-41 141.1 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 CCF48123.1 - 3.5e-05 23.6 0.2 0.00023 21.0 0.2 2.1 1 1 0 1 1 1 1 Peptidase C26 QRPTase_C PF01729.19 CCF48123.1 - 0.01 15.6 0.0 0.04 13.7 0.0 2.0 1 0 0 1 1 1 0 Quinolinate phosphoribosyl transferase, C-terminal domain NanE PF04131.14 CCF48123.1 - 0.012 14.8 0.1 4 6.6 0.0 2.8 2 0 0 2 2 2 0 Putative N-acetylmannosamine-6-phosphate epimerase HEAT PF02985.22 CCF48124.1 - 2.9e-21 73.7 15.1 0.00012 22.0 0.0 11.0 11 0 0 11 11 10 4 HEAT repeat HEAT_EZ PF13513.6 CCF48124.1 - 3.9e-14 52.8 18.9 2.6e-09 37.4 0.0 8.3 9 2 2 11 11 10 4 HEAT-like repeat HEAT_2 PF13646.6 CCF48124.1 - 1.2e-09 38.4 14.4 0.00096 19.5 0.0 6.6 4 2 5 9 9 8 6 HEAT repeats IBN_N PF03810.19 CCF48124.1 - 6.1e-09 35.7 2.6 6.2e-08 32.4 0.0 3.7 4 0 0 4 4 4 1 Importin-beta N-terminal domain Arm PF00514.23 CCF48124.1 - 3.8e-07 29.9 10.0 0.015 15.4 0.0 5.5 5 0 0 5 5 5 2 Armadillo/beta-catenin-like repeat Cnd1 PF12717.7 CCF48124.1 - 0.00015 21.9 0.0 0.0053 16.8 0.0 3.3 3 1 1 4 4 4 1 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 CCF48124.1 - 0.0031 16.2 0.2 0.31 9.6 0.0 3.6 2 2 0 3 3 3 1 Adaptin N terminal region TIP120 PF08623.10 CCF48124.1 - 0.015 15.1 0.3 1.1 9.1 0.0 3.0 3 0 0 3 3 3 0 TATA-binding protein interacting (TIP20) CLASP_N PF12348.8 CCF48124.1 - 0.045 13.3 0.1 48 3.4 0.0 4.0 4 1 1 5 5 5 0 CLASP N terminal HEAT_PBS PF03130.16 CCF48124.1 - 0.2 12.4 5.6 30 5.7 0.0 5.1 5 0 0 5 5 4 0 PBS lyase HEAT-like repeat Cnd3 PF12719.7 CCF48124.1 - 0.21 10.7 0.7 1.8 7.7 0.2 2.8 2 1 0 2 2 2 0 Nuclear condensing complex subunits, C-term domain RT_RNaseH_2 PF17919.1 CCF48126.1 - 0.0024 17.9 0.1 0.0091 16.0 0.1 2.0 3 0 0 3 3 3 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 CCF48126.1 - 0.0033 17.0 0.0 0.0053 16.3 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 CCF48127.1 - 3.1e-08 33.6 2.1 6.8e-08 32.5 2.1 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain D5_N PF08706.11 CCF48127.1 - 0.042 14.1 0.0 0.1 12.9 0.0 1.5 2 0 0 2 2 2 0 D5 N terminal like rve PF00665.26 CCF48127.1 - 0.091 13.0 0.0 0.2 11.8 0.0 1.6 1 0 0 1 1 1 0 Integrase core domain Laminin_G_3 PF13385.6 CCF48128.1 - 0.052 13.7 0.1 0.052 13.7 0.1 1.1 1 0 0 1 1 1 0 Concanavalin A-like lectin/glucanases superfamily rve PF00665.26 CCF48129.1 - 1e-06 28.9 0.0 1.3e-06 28.6 0.0 1.1 1 0 0 1 1 1 1 Integrase core domain SCAB-PH PF17684.1 CCF48129.1 - 0.14 12.4 0.0 0.25 11.6 0.0 1.4 1 1 0 1 1 1 0 PH domain of plant-specific actin-binding protein RVT_2 PF07727.14 CCF48132.1 - 1.9e-36 126.0 1.3 2.4e-36 125.6 1.3 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_2 PF07727.14 CCF48133.1 - 2.3e-46 158.4 0.3 9.8e-33 113.8 0.1 2.0 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_2 PF07727.14 CCF48135.1 - 0.0051 16.5 0.2 0.0072 16.0 0.2 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) PC4 PF02229.16 CCF48135.1 - 0.14 11.8 0.3 0.63 9.7 0.0 2.0 2 0 0 2 2 2 0 Transcriptional Coactivator p15 (PC4) Chromo PF00385.24 CCF48136.1 - 5.1e-11 42.3 0.2 1.3e-10 41.0 0.1 1.7 1 1 1 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain RVT_1 PF00078.27 CCF48138.1 - 7.3e-26 91.0 0.0 2.4e-25 89.4 0.0 1.8 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF4256 PF14066.6 CCF48138.1 - 0.018 14.8 0.1 0.032 13.9 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4256) Asp_protease_2 PF13650.6 CCF48138.1 - 0.037 14.7 0.0 0.082 13.6 0.0 1.6 1 0 0 1 1 1 0 Aspartyl protease gag-asp_proteas PF13975.6 CCF48138.1 - 0.14 12.7 0.0 0.43 11.2 0.0 1.8 2 0 0 2 2 2 0 gag-polyprotein putative aspartyl protease RT_RNaseH PF17917.1 CCF48139.1 - 4.4e-21 75.1 0.0 1.3e-20 73.6 0.0 1.9 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 CCF48139.1 - 1e-15 57.6 0.0 4.2e-09 36.4 0.0 3.0 3 0 0 3 3 3 2 RNase H-like domain found in reverse transcriptase rve_3 PF13683.6 CCF48139.1 - 7.1e-06 25.7 1.4 1.6e-05 24.6 0.1 2.2 2 0 0 2 2 2 1 Integrase core domain zf-CCHC PF00098.23 CCF48139.1 - 0.00016 21.6 1.7 0.00045 20.2 1.7 1.9 1 0 0 1 1 1 1 Zinc knuckle rve PF00665.26 CCF48139.1 - 0.00017 21.8 0.0 0.00039 20.6 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain WRNPLPNID PF15017.6 CCF48140.1 - 0.064 14.1 0.9 0.064 14.1 0.9 2.0 2 0 0 2 2 2 0 Putative WW-binding domain and destruction box SAM_DrpA PF18255.1 CCF48140.1 - 0.071 13.4 0.2 0.11 12.7 0.2 1.3 1 0 0 1 1 1 0 DNA processing protein A sterile alpha motif domain DUF883 PF05957.13 CCF48142.1 - 1.6e-05 25.4 28.4 0.092 13.4 5.4 4.0 1 1 3 4 4 4 4 Bacterial protein of unknown function (DUF883) YtxH PF12732.7 CCF48142.1 - 0.0024 18.4 28.3 2.9e+02 2.1 10.8 4.6 1 1 1 2 2 2 0 YtxH-like protein LEA_4 PF02987.16 CCF48142.1 - 0.0069 16.5 22.6 0.015 15.4 7.9 4.5 4 2 1 5 5 5 2 Late embryogenesis abundant protein Apolipoprotein PF01442.18 CCF48142.1 - 0.13 12.2 27.5 1.4 8.7 8.8 2.2 1 1 1 2 2 2 0 Apolipoprotein A1/A4/E domain Chlorosome_CsmC PF11098.8 CCF48142.1 - 0.21 11.6 22.7 0.071 13.1 7.8 3.5 1 1 2 3 3 3 0 Chlorosome envelope protein C DUF948 PF06103.11 CCF48142.1 - 0.22 11.8 15.1 22 5.4 5.8 4.6 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) ApoLp-III PF07464.11 CCF48142.1 - 1.1 9.3 28.9 6.9 6.8 6.0 3.6 1 1 1 2 2 2 0 Apolipophorin-III precursor (apoLp-III) Phage_Coat_Gp8 PF05371.12 CCF48142.1 - 3 7.7 0.0 3 7.7 0.0 4.2 4 1 1 5 5 5 0 Phage major coat protein, Gp8 REF PF05755.12 CCF48142.1 - 3.1 7.6 14.8 3.6 7.3 5.8 3.1 1 1 1 2 2 2 0 Rubber elongation factor protein (REF) HisKA_3 PF07730.13 CCF48142.1 - 5.5 7.6 17.7 8.2 7.0 0.1 4.6 1 1 3 4 4 4 0 Histidine kinase RRF PF01765.19 CCF48142.1 - 5.9 6.8 10.5 1.4 8.9 1.1 3.0 2 2 1 3 3 3 0 Ribosome recycling factor Phasin_2 PF09361.10 CCF48142.1 - 7 7.0 34.2 0.22 11.8 10.3 3.3 2 2 0 2 2 2 0 Phasin protein SOAR PF16533.5 CCF48142.1 - 9.3 6.3 9.1 3.5 7.6 0.1 3.2 1 1 3 4 4 4 0 STIM1 Orai1-activating region NYN PF01936.18 CCF48145.1 - 4.4e-27 95.4 0.0 9.4e-27 94.3 0.0 1.5 1 0 0 1 1 1 1 NYN domain NAPRTase_C PF17956.1 CCF48146.1 - 0.094 13.2 0.0 0.17 12.3 0.0 1.4 1 0 0 1 1 1 0 Nicotinate phosphoribosyltransferase C-terminal domain Alveol-reg_P311 PF11092.8 CCF48147.1 - 0.1 12.8 0.0 0.31 11.2 0.0 1.8 1 0 0 1 1 1 0 Neuronal protein 3.1 (p311) RVT_1 PF00078.27 CCF48148.1 - 5.7e-08 32.5 0.0 9.2e-08 31.9 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 CCF48148.1 - 7e-06 26.3 0.0 1.5e-05 25.2 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 CCF48148.1 - 2.3e-05 24.3 0.0 5.2e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase DUF4395 PF14340.6 CCF48148.1 - 1 9.7 6.8 1.1 9.6 0.6 2.9 2 1 0 3 3 3 0 Domain of unknown function (DUF4395) MTHFR PF02219.17 CCF48149.1 - 2.3e-111 371.7 0.0 3.4e-111 371.2 0.0 1.2 1 0 0 1 1 1 1 Methylenetetrahydrofolate reductase Skp1 PF01466.19 CCF48150.1 - 4.5e-29 100.3 0.3 7.7e-29 99.6 0.3 1.4 1 0 0 1 1 1 1 Skp1 family, dimerisation domain Skp1_POZ PF03931.15 CCF48150.1 - 2.1e-26 91.9 0.2 5.4e-26 90.5 0.1 1.8 2 0 0 2 2 2 1 Skp1 family, tetramerisation domain BTB PF00651.31 CCF48150.1 - 0.014 15.6 0.0 0.19 12.0 0.0 2.1 1 1 0 1 1 1 0 BTB/POZ domain Med12 PF09497.10 CCF48151.1 - 0.0038 17.5 0.0 0.0085 16.4 0.0 1.5 1 0 0 1 1 1 1 Transcription mediator complex subunit Med12 Paf1 PF03985.13 CCF48152.1 - 1.3e-51 176.0 17.5 1.5e-48 165.9 0.0 3.7 2 2 1 3 3 3 2 Paf1 4HBT PF03061.22 CCF48153.1 - 7.1e-06 26.3 0.0 1.4e-05 25.4 0.0 1.5 1 0 0 1 1 1 1 Thioesterase superfamily RT_RNaseH PF17917.1 CCF48155.1 - 1.1e-40 138.1 0.0 4.6e-40 136.1 0.0 1.9 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 CCF48155.1 - 4.1e-36 123.0 0.0 1.1e-35 121.6 0.0 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 CCF48155.1 - 3.7e-19 69.1 0.1 1e-18 67.7 0.0 1.8 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1118 PF06549.12 CCF48155.1 - 0.12 12.7 0.0 0.23 11.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1118) DUF3085 PF11284.8 CCF48155.1 - 0.14 12.5 0.0 0.6 10.5 0.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3085) PIP5K PF01504.18 CCF48156.1 - 3.6e-43 147.8 0.0 2.5e-34 118.8 0.1 2.8 1 1 1 2 2 2 2 Phosphatidylinositol-4-phosphate 5-Kinase Cpn60_TCP1 PF00118.24 CCF48156.1 - 6.4e-25 87.7 0.0 1.1e-24 87.0 0.0 1.2 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family FYVE PF01363.21 CCF48156.1 - 1.2e-15 57.3 10.8 3.8e-15 55.8 10.8 1.9 1 0 0 1 1 1 1 FYVE zinc finger IPPT PF01715.17 CCF48156.1 - 0.16 11.8 0.0 0.34 10.7 0.0 1.4 1 0 0 1 1 1 0 IPP transferase CENP-B_dimeris PF09026.10 CCF48156.1 - 1.1 9.7 7.4 3.7 8.0 7.4 1.9 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DNA_pol_phi PF04931.13 CCF48156.1 - 8.3 4.4 10.6 16 3.4 10.6 1.4 1 0 0 1 1 1 0 DNA polymerase phi Cpn60_TCP1 PF00118.24 CCF48157.1 - 1.8e-160 534.8 2.0 2.1e-160 534.6 2.0 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family PNTB_4TM PF12769.7 CCF48157.1 - 0.1 13.1 0.0 0.25 11.8 0.0 1.6 1 0 0 1 1 1 0 4TM region of pyridine nucleotide transhydrogenase, mitoch A_deaminase PF00962.22 CCF48158.1 - 3.4e-34 118.7 0.0 5.4e-34 118.0 0.0 1.3 1 0 0 1 1 1 1 Adenosine/AMP deaminase F-box-like PF12937.7 CCF48159.1 - 1.1e-08 34.9 0.0 2.7e-08 33.6 0.0 1.8 1 0 0 1 1 1 1 F-box-like LRR_6 PF13516.6 CCF48159.1 - 2.3e-08 33.4 6.7 0.9 9.8 0.1 7.1 8 0 0 8 8 8 2 Leucine Rich repeat LRR_4 PF12799.7 CCF48159.1 - 3.3e-06 27.3 7.7 1.9 9.0 0.4 5.8 5 1 2 7 7 7 3 Leucine Rich repeats (2 copies) F-box PF00646.33 CCF48159.1 - 0.0012 18.6 5.7 0.031 14.2 0.0 3.8 4 0 0 4 4 4 1 F-box domain LRR_1 PF00560.33 CCF48159.1 - 0.0098 16.3 8.0 45 5.2 0.0 6.0 5 1 0 5 5 5 0 Leucine Rich Repeat HAGH_C PF16123.5 CCF48160.1 - 4.1e-21 75.3 0.1 6.5e-21 74.6 0.1 1.3 1 0 0 1 1 1 1 Hydroxyacylglutathione hydrolase C-terminus Lactamase_B PF00753.27 CCF48160.1 - 2.8e-12 47.1 2.6 8e-12 45.6 2.6 1.7 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily BssS PF13991.6 CCF48161.1 - 0.19 11.9 0.6 19 5.4 0.4 2.5 2 0 0 2 2 2 0 BssS protein family Ribosomal_S7 PF00177.21 CCF48162.1 - 1.9e-37 128.2 1.4 2.5e-37 127.8 1.4 1.1 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e WD40 PF00400.32 CCF48163.1 - 3.9e-40 135.1 7.4 1.9e-06 28.5 0.0 8.7 8 0 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF48163.1 - 1.3e-17 63.9 0.0 3.2e-05 24.1 0.0 5.5 3 2 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain LisH PF08513.11 CCF48163.1 - 1.1e-05 25.2 0.2 1.9e-05 24.4 0.2 1.4 1 0 0 1 1 1 1 LisH eIF2A PF08662.11 CCF48163.1 - 0.0024 17.8 0.0 0.066 13.1 0.0 2.5 2 0 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 CCF48163.1 - 0.058 12.7 0.0 3.1 7.0 0.0 2.5 2 0 0 2 2 2 0 WD40-like domain Macoilin PF09726.9 CCF48163.1 - 6.4 5.2 32.0 0.031 12.9 22.7 1.7 3 0 0 3 3 3 0 Macoilin family LAP1C PF05609.12 CCF48163.1 - 9.7 5.1 25.5 20 4.1 25.5 1.4 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) CDC45 PF02724.14 CCF48165.1 - 0.012 13.9 10.2 0.013 13.9 10.2 1.0 1 0 0 1 1 1 0 CDC45-like protein LAP1C PF05609.12 CCF48165.1 - 0.018 14.2 10.5 0.02 14.0 10.5 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Raftlin PF15250.6 CCF48165.1 - 0.22 10.2 7.5 0.23 10.2 7.5 1.0 1 0 0 1 1 1 0 Raftlin Sin_N PF04801.13 CCF48165.1 - 0.58 9.3 11.8 0.69 9.1 11.8 1.1 1 0 0 1 1 1 0 Sin-like protein conserved region CCDC106 PF15794.5 CCF48165.1 - 0.66 9.6 12.0 0.85 9.3 12.0 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 Zip PF02535.22 CCF48165.1 - 0.92 8.7 6.7 1 8.5 6.7 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter XAP5 PF04921.14 CCF48165.1 - 1 9.1 11.7 1.4 8.7 11.7 1.3 1 0 0 1 1 1 0 XAP5, circadian clock regulator CDC27 PF09507.10 CCF48165.1 - 1.6 8.0 19.2 1.8 7.9 19.2 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 PRTP PF01366.18 CCF48165.1 - 1.6 6.7 5.6 3.4 5.6 5.4 1.6 1 1 0 1 1 1 0 Herpesvirus processing and transport protein Presenilin PF01080.17 CCF48165.1 - 2.1 7.0 11.6 2.3 6.9 11.6 1.1 1 0 0 1 1 1 0 Presenilin RR_TM4-6 PF06459.12 CCF48165.1 - 2.6 7.8 17.2 3.1 7.5 17.2 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Sec62 PF03839.16 CCF48165.1 - 2.7 7.5 6.7 3 7.3 6.7 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 DUF4407 PF14362.6 CCF48165.1 - 3 7.1 7.2 3.7 6.8 7.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) NPR3 PF03666.13 CCF48165.1 - 3.6 6.3 11.9 4.2 6.1 11.9 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 PGA2 PF07543.12 CCF48165.1 - 4.4 7.3 14.7 6.8 6.7 14.7 1.3 1 0 0 1 1 1 0 Protein trafficking PGA2 RPN2_C PF18004.1 CCF48165.1 - 4.8 7.1 14.8 7.3 6.5 14.8 1.3 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain DDRGK PF09756.9 CCF48165.1 - 5.2 6.6 17.7 6.6 6.3 17.7 1.1 1 0 0 1 1 1 0 DDRGK domain DUF913 PF06025.12 CCF48165.1 - 6.6 5.6 9.0 8.2 5.3 9.0 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) SLC12 PF03522.15 CCF48165.1 - 6.7 5.6 8.9 7.3 5.5 8.9 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Sporozoite_P67 PF05642.11 CCF48165.1 - 7 4.6 10.3 7.7 4.5 10.3 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Neur_chan_memb PF02932.16 CCF48165.1 - 7.1 6.6 6.9 8.9 6.3 6.9 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region MDFI PF15316.6 CCF48165.1 - 8.8 6.4 6.7 11 6.1 6.7 1.2 1 0 0 1 1 1 0 MyoD family inhibitor RVT_2 PF07727.14 CCF48169.1 - 2.3e-46 158.4 0.0 2.5e-46 158.3 0.0 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) FHA_2 PF17913.1 CCF48169.1 - 0.17 12.1 0.0 0.3 11.4 0.0 1.3 1 0 0 1 1 1 0 FHA domain PGC7_Stella PF15549.6 CCF48171.1 - 0.06 13.3 2.3 4.7 7.2 0.4 2.4 1 1 1 2 2 2 0 PGC7/Stella/Dppa3 domain rve PF00665.26 CCF48172.1 - 4.9e-12 46.1 0.2 6.4e-12 45.7 0.2 1.1 1 0 0 1 1 1 1 Integrase core domain Guanylin PF02058.15 CCF48172.1 - 0.061 13.8 0.0 0.49 10.9 0.0 2.0 2 0 0 2 2 2 0 Guanylin precursor DUF5614 PF18474.1 CCF48172.1 - 0.078 12.3 0.0 0.11 11.8 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5614) Phage_XkdX PF09693.10 CCF48173.1 - 0.039 14.0 0.0 0.085 12.9 0.0 1.5 1 0 0 1 1 1 0 Phage uncharacterised protein (Phage_XkdX) SNF2_N PF00176.23 CCF48174.1 - 3e-61 207.1 0.0 4.6e-61 206.5 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 CCF48174.1 - 1.7e-12 47.6 0.0 4.7e-12 46.2 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 CCF48174.1 - 2.7e-06 27.5 0.0 0.00067 19.7 0.0 2.6 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit zf-RING_5 PF14634.6 CCF48174.1 - 4.9e-05 23.2 0.5 4.9e-05 23.2 0.5 1.8 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4 PF00097.25 CCF48174.1 - 0.00028 20.7 0.6 0.00079 19.3 0.6 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 CCF48174.1 - 0.0012 18.6 0.7 0.0032 17.3 0.7 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 CCF48174.1 - 0.0036 17.6 1.7 0.0099 16.2 1.7 1.8 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 CCF48174.1 - 0.024 14.7 0.2 0.073 13.1 0.2 1.9 1 0 0 1 1 1 0 RING-type zinc-finger DZR PF12773.7 CCF48174.1 - 0.071 13.1 1.9 4 7.5 1.0 2.4 2 0 0 2 2 2 0 Double zinc ribbon zf-C3HC4_2 PF13923.6 CCF48174.1 - 0.087 12.7 6.6 0.33 10.9 6.6 2.0 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) PNP_UDP_1 PF01048.20 CCF48175.1 - 1.6e-36 125.7 0.0 1.9e-36 125.5 0.0 1.1 1 0 0 1 1 1 1 Phosphorylase superfamily MMR_HSR1 PF01926.23 CCF48176.1 - 5.3e-14 52.3 0.0 2.3e-13 50.2 0.0 2.0 2 0 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CCF48176.1 - 5e-07 29.8 0.0 0.0046 16.9 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase FeoB_N PF02421.18 CCF48176.1 - 9.2e-05 22.0 0.0 0.001 18.6 0.1 2.4 3 0 0 3 3 3 1 Ferrous iron transport protein B Dynamin_N PF00350.23 CCF48176.1 - 0.0039 17.2 0.1 0.02 15.0 0.2 2.1 2 0 0 2 2 2 1 Dynamin family Septin PF00735.18 CCF48176.1 - 0.1 11.9 0.0 0.84 8.9 0.0 2.1 2 0 0 2 2 2 0 Septin Metal_resist PF13801.6 CCF48176.1 - 0.12 12.6 0.8 20 5.4 0.2 2.8 2 0 0 2 2 2 0 Heavy-metal resistance NIF PF03031.18 CCF48177.1 - 2.2e-21 76.2 0.0 4.6e-21 75.2 0.0 1.5 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase GREB1 PF15782.5 CCF48177.1 - 0.85 6.7 12.4 1.6 5.8 12.4 1.3 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DPBB_1 PF03330.18 CCF48178.1 - 6.3e-05 23.2 0.1 0.00012 22.2 0.1 1.5 1 0 0 1 1 1 1 Lytic transglycolase SOG2 PF10428.9 CCF48178.1 - 0.0021 17.3 15.2 0.0023 17.2 15.2 1.2 1 0 0 1 1 1 1 RAM signalling pathway protein Apt1 PF10351.9 CCF48178.1 - 0.2 10.5 10.5 0.27 10.0 10.5 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain Hid1 PF12722.7 CCF48178.1 - 2.2 6.3 6.5 2.7 6.0 6.5 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Presenilin PF01080.17 CCF48178.1 - 2.9 6.6 8.7 4.5 5.9 8.7 1.2 1 0 0 1 1 1 0 Presenilin DUF4551 PF15087.6 CCF48178.1 - 3.3 6.4 6.2 4.5 6.0 6.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) RVT_2 PF07727.14 CCF48184.1 - 2.9e-14 53.3 0.0 3.1e-14 53.2 0.0 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP_2 PF08284.11 CCF48188.1 - 1.8e-05 24.5 0.0 2.9e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease_2 PF13650.6 CCF48188.1 - 0.0023 18.5 0.0 0.004 17.8 0.0 1.4 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 CCF48188.1 - 0.014 16.0 0.0 0.024 15.2 0.0 1.4 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease RVT_1 PF00078.27 CCF48188.1 - 0.065 12.7 0.0 0.091 12.3 0.0 1.2 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) RVP_2 PF08284.11 CCF48189.1 - 0.00027 20.7 0.0 0.00045 20.0 0.0 1.3 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease_2 PF13650.6 CCF48189.1 - 0.016 15.8 0.0 0.03 15.0 0.0 1.5 1 0 0 1 1 1 0 Aspartyl protease gag-asp_proteas PF13975.6 CCF48189.1 - 0.038 14.6 0.0 0.063 13.8 0.0 1.4 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease gag_pre-integrs PF13976.6 CCF48192.1 - 2.2e-05 24.2 1.2 4.1e-05 23.3 1.2 1.5 1 0 0 1 1 1 1 GAG-pre-integrase domain DUF713 PF05218.14 CCF48196.1 - 0.16 11.7 0.0 0.23 11.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF713) rve PF00665.26 CCF48198.1 - 3.3e-17 62.8 0.1 9.4e-17 61.3 0.1 1.8 1 0 0 1 1 1 1 Integrase core domain zf-C2H2_9 PF16293.5 CCF48199.1 - 0.0025 17.6 0.3 2.5 8.0 0.1 2.5 2 0 0 2 2 2 2 C2H2 type zinc-finger (1 copy) zf-C2H2_4 PF13894.6 CCF48199.1 - 0.084 13.8 2.8 1.6 9.7 0.3 2.9 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2 PF00096.26 CCF48199.1 - 0.86 10.2 3.7 4.5 7.9 0.5 3.0 2 0 0 2 2 2 0 Zinc finger, C2H2 type zinc_ribbon_4 PF13717.6 CCF48199.1 - 1.5 8.8 3.2 6.4 6.8 0.3 2.4 2 0 0 2 2 2 0 zinc-ribbon domain LSM PF01423.22 CCF48200.1 - 5.5e-18 64.4 0.0 9.6e-18 63.7 0.0 1.3 1 1 0 1 1 1 1 LSM domain HalX PF08663.10 CCF48200.1 - 0.064 13.6 0.3 0.097 13.0 0.3 1.2 1 0 0 1 1 1 0 HalX domain MFS_1 PF07690.16 CCF48201.1 - 1.3e-30 106.5 25.5 1.3e-30 106.5 25.5 1.7 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF48201.1 - 2e-13 50.0 17.5 1.7e-12 47.0 8.2 3.2 2 1 1 3 3 3 2 Sugar (and other) transporter OATP PF03137.20 CCF48201.1 - 0.00036 18.9 1.3 0.0011 17.4 1.3 1.9 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family Hydrolase_4 PF12146.8 CCF48203.1 - 1.2e-12 47.7 0.0 1.7e-08 34.1 0.0 2.1 2 0 0 2 2 2 2 Serine aminopeptidase, S33 AXE1 PF05448.12 CCF48203.1 - 2.3e-09 36.4 0.0 1.6e-07 30.3 0.0 2.3 2 1 0 2 2 2 1 Acetyl xylan esterase (AXE1) Abhydrolase_1 PF00561.20 CCF48203.1 - 6.5e-09 35.8 0.1 5e-07 29.6 0.1 2.1 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CCF48203.1 - 7.5e-08 33.2 0.1 9.5e-08 32.9 0.1 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S15 PF02129.18 CCF48203.1 - 1.5e-07 31.3 0.0 2e-07 30.9 0.0 1.1 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) Peptidase_S9 PF00326.21 CCF48203.1 - 2.7e-06 27.0 0.0 7.3e-06 25.6 0.0 1.7 1 0 0 1 1 1 1 Prolyl oligopeptidase family DLH PF01738.18 CCF48203.1 - 8.3e-06 25.5 0.0 0.00026 20.6 0.0 2.5 2 1 0 2 2 2 1 Dienelactone hydrolase family PAF-AH_p_II PF03403.13 CCF48203.1 - 1.1e-05 24.2 0.2 0.088 11.3 0.0 2.3 1 1 1 2 2 2 2 Platelet-activating factor acetylhydrolase, isoform II BAAT_C PF08840.11 CCF48203.1 - 2.3e-05 24.4 0.0 7.5e-05 22.8 0.0 1.7 2 0 0 2 2 2 1 BAAT / Acyl-CoA thioester hydrolase C terminal Abhydrolase_3 PF07859.13 CCF48203.1 - 0.0043 16.9 0.0 0.035 13.9 0.0 2.2 1 1 1 2 2 2 1 alpha/beta hydrolase fold DUF1100 PF06500.11 CCF48203.1 - 0.0063 15.4 0.0 0.0085 14.9 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1100) BRCT_2 PF16589.5 CCF48204.1 - 1.5e-24 86.2 0.0 0.006 17.0 0.0 6.4 6 0 0 6 6 6 5 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 CCF48204.1 - 2.7e-24 85.3 0.1 1.4e-10 41.4 0.0 6.8 6 1 0 6 6 6 4 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 CCF48204.1 - 2.8e-16 59.2 1.2 2.1e-14 53.2 0.3 3.8 5 0 0 5 5 5 1 twin BRCT domain RTT107_BRCT_5 PF16770.5 CCF48204.1 - 7.7e-14 51.4 0.1 7.1e-13 48.3 0.0 2.6 3 0 0 3 3 3 1 Regulator of Ty1 transposition protein 107 BRCT domain BRCT_3 PF18428.1 CCF48204.1 - 0.0035 17.4 0.3 0.66 10.1 0.1 3.3 3 0 0 3 3 3 1 BRCA1 C Terminus (BRCT) domain DUF2117 PF09890.9 CCF48204.1 - 0.078 12.4 0.0 0.16 11.4 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2117) RRM_1 PF00076.22 CCF48205.1 - 2.4e-13 49.7 0.0 3.9e-13 49.0 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FoP_duplication PF13865.6 CCF48205.1 - 3.4e-07 30.7 19.6 1.2e-06 28.9 8.2 2.4 2 0 0 2 2 2 2 C-terminal duplication domain of Friend of PRMT1 RRM_occluded PF16842.5 CCF48205.1 - 0.0019 18.0 0.0 0.004 17.0 0.0 1.5 1 0 0 1 1 1 1 Occluded RNA-recognition motif RSN1_7TM PF02714.15 CCF48206.1 - 7.4e-75 251.8 24.8 1.4e-74 250.9 24.8 1.4 1 0 0 1 1 1 1 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 CCF48206.1 - 3.3e-37 127.6 1.6 1.1e-36 125.9 1.6 2.0 1 0 0 1 1 1 1 Late exocytosis, associated with Golgi transport PHM7_cyt PF14703.6 CCF48206.1 - 1.9e-34 119.4 0.0 3.2e-34 118.7 0.0 1.4 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter Beach PF02138.18 CCF48207.1 - 2.7e-114 381.2 0.0 4.1e-114 380.6 0.0 1.3 1 0 0 1 1 1 1 Beige/BEACH domain WD40 PF00400.32 CCF48207.1 - 5e-09 36.7 3.3 0.019 15.8 0.6 5.0 4 0 0 4 4 4 3 WD domain, G-beta repeat PH_BEACH PF14844.6 CCF48207.1 - 4.1e-08 33.2 0.0 1.1e-07 31.8 0.0 1.7 1 0 0 1 1 1 1 PH domain associated with Beige/BEACH DUF4704 PF15787.5 CCF48207.1 - 0.00023 20.5 0.4 0.00023 20.5 0.4 3.5 4 0 0 4 4 4 1 Domain of unknown function (DUF4704) FYVE PF01363.21 CCF48207.1 - 0.00048 20.2 8.1 0.001 19.1 8.1 1.6 1 0 0 1 1 1 1 FYVE zinc finger DUF4800 PF16057.5 CCF48207.1 - 0.056 12.7 2.5 0.13 11.5 2.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4800) IBR PF01485.21 CCF48207.1 - 1.5 9.1 6.1 0.42 10.9 2.8 1.8 1 1 0 1 1 1 0 IBR domain, a half RING-finger domain Kre28 PF17097.5 CCF48207.1 - 4.4 6.1 5.8 0.84 8.5 1.9 1.6 2 0 0 2 2 2 0 Spindle pole body component zf-C3HC4_3 PF13920.6 CCF48207.1 - 4.6 7.2 5.6 8.5 6.3 5.6 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) HSP20 PF00011.21 CCF48208.1 - 6.9e-18 64.7 0.4 4.5e-13 49.2 0.4 2.1 1 1 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 CCF48208.1 - 2.2e-06 27.1 0.0 1.2e-05 24.8 0.0 2.1 1 1 0 1 1 1 1 HSP20-like domain found in ArsA GvpH PF05455.11 CCF48208.1 - 0.011 15.9 0.0 0.02 15.0 0.0 1.4 1 0 0 1 1 1 0 GvpH PI-PLC-C1 PF16670.5 CCF48209.1 - 0.0014 17.7 0.4 0.46 9.5 0.0 2.8 3 0 0 3 3 3 2 Phosphoinositide phospholipase C, Ca2+-dependent PI-PLC-X PF00388.19 CCF48209.1 - 0.068 12.8 0.1 0.14 11.7 0.1 1.5 1 0 0 1 1 1 0 Phosphatidylinositol-specific phospholipase C, X domain DUF5470 PF17564.2 CCF48209.1 - 0.51 10.6 8.9 2.3 8.5 8.9 2.2 1 0 0 1 1 1 0 Family of unknown function (DUF5470) RAP1 PF07218.11 CCF48209.1 - 1.9 6.7 4.4 2.5 6.3 4.4 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) BRO1 PF03097.18 CCF48210.1 - 2.3e-118 395.4 0.0 5.3e-118 394.2 0.0 1.6 2 0 0 2 2 2 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.6 CCF48210.1 - 4.8e-74 249.3 0.1 8.5e-74 248.5 0.1 1.4 1 0 0 1 1 1 1 ALIX V-shaped domain binding to HIV Spt20 PF12090.8 CCF48210.1 - 0.33 10.5 14.3 0.56 9.8 14.3 1.3 1 0 0 1 1 1 0 Spt20 family DUF908 PF06012.12 CCF48210.1 - 1.5 8.2 7.3 0.83 9.0 5.2 1.6 2 0 0 2 2 2 0 Domain of Unknown Function (DUF908) WGG PF10273.9 CCF48211.1 - 7.4e-22 77.8 0.0 1.2e-21 77.1 0.0 1.4 1 0 0 1 1 1 1 Pre-rRNA-processing protein TSR2 SNN_linker PF09050.10 CCF48212.1 - 3 7.7 6.6 9.6 6.1 0.7 3.2 3 0 0 3 3 3 0 Stannin unstructured linker Voltage_CLC PF00654.20 CCF48213.1 - 6.6e-90 301.9 26.3 6.6e-90 301.9 26.3 1.6 2 0 0 2 2 2 1 Voltage gated chloride channel CBS PF00571.28 CCF48213.1 - 0.095 13.2 0.0 0.36 11.3 0.0 2.0 2 0 0 2 2 2 0 CBS domain TspO_MBR PF03073.15 CCF48213.1 - 0.12 12.4 0.1 0.12 12.4 0.1 3.2 2 1 1 3 3 3 0 TspO/MBR family Ribophorin_II PF05817.14 CCF48213.1 - 4.1 5.8 4.1 6.3 5.2 4.1 1.1 1 0 0 1 1 1 0 Oligosaccharyltransferase subunit Ribophorin II DUF2754 PF10953.8 CCF48213.1 - 5.8 7.2 6.9 15 5.9 0.5 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF2754) DASH_Hsk3 PF08227.11 CCF48214.1 - 1.1e-14 54.5 1.1 1.4e-14 54.1 1.1 1.2 1 0 0 1 1 1 1 DASH complex subunit Hsk3 like LRR_8 PF13855.6 CCF48215.1 - 1.3e-08 34.4 5.4 3.4e-08 33.1 5.0 1.9 2 0 0 2 2 2 1 Leucine rich repeat LRR_4 PF12799.7 CCF48215.1 - 4.1e-05 23.8 8.2 0.00049 20.4 1.6 2.8 2 1 1 3 3 3 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 CCF48215.1 - 1.5 9.7 3.6 29 5.8 0.8 3.6 2 1 0 2 2 2 0 Leucine Rich Repeat UPRTase PF14681.6 CCF48216.1 - 7.7e-79 263.9 0.0 8.8e-79 263.8 0.0 1.0 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Pribosyltran PF00156.27 CCF48216.1 - 0.00027 20.5 0.0 0.00036 20.1 0.0 1.2 1 0 0 1 1 1 1 Phosphoribosyl transferase domain ESCRT-II PF05871.12 CCF48217.1 - 8.4e-47 158.9 0.1 1.2e-46 158.4 0.1 1.2 1 0 0 1 1 1 1 ESCRT-II complex subunit PAS_12 PF18095.1 CCF48217.1 - 0.042 13.5 0.2 0.11 12.1 0.1 1.6 1 1 0 2 2 2 0 UPF0242 C-terminal PAS-like domain Rxt3 PF08642.10 CCF48218.1 - 3.2e-23 82.9 0.0 3.2e-23 82.9 0.0 3.8 3 0 0 3 3 3 1 Histone deacetylation protein Rxt3 LCCL PF03815.19 CCF48218.1 - 0.085 13.0 0.0 1.3 9.1 0.0 2.3 2 0 0 2 2 2 0 LCCL domain DEAD PF00270.29 CCF48219.1 - 1.4e-36 125.9 0.1 2.6e-36 125.0 0.1 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CCF48219.1 - 1e-28 99.9 0.0 3.5e-28 98.2 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain YL1 PF05764.13 CCF48219.1 - 2.1e-05 24.8 1.6 4e-05 23.8 1.6 1.4 1 0 0 1 1 1 1 YL1 nuclear protein CDC45 PF02724.14 CCF48219.1 - 0.00032 19.2 2.3 0.00043 18.7 2.3 1.1 1 0 0 1 1 1 1 CDC45-like protein ResIII PF04851.15 CCF48219.1 - 0.00037 20.5 0.5 0.00099 19.1 0.0 2.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit zf-CCCH PF00642.24 CCF48220.1 - 6.1e-13 48.3 14.9 1.3e-06 28.2 2.8 2.4 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 CCF48220.1 - 0.0041 17.1 10.9 0.0085 16.1 3.3 2.6 2 0 0 2 2 2 2 Zinc finger domain RRM_1 PF00076.22 CCF48220.1 - 0.019 14.8 0.0 0.078 12.8 0.0 1.9 1 1 1 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCCH_3 PF15663.5 CCF48220.1 - 0.13 12.5 6.5 0.14 12.3 1.0 2.3 2 0 0 2 2 2 0 Zinc-finger containing family Y_phosphatase2 PF03162.13 CCF48221.1 - 1.6e-48 164.4 0.0 1.8e-48 164.2 0.0 1.0 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.6 CCF48221.1 - 0.00026 21.1 0.0 0.0013 18.7 0.0 1.9 1 1 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.20 CCF48221.1 - 0.0073 16.1 0.0 0.01 15.7 0.0 1.4 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 CCF48221.1 - 0.051 13.1 0.0 0.061 12.9 0.0 1.1 1 0 0 1 1 1 0 Protein-tyrosine phosphatase XPG_N PF00752.17 CCF48222.1 - 3.4e-29 101.3 0.0 6.2e-29 100.5 0.0 1.5 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.18 CCF48222.1 - 7.5e-26 90.3 0.0 1.9e-25 89.0 0.0 1.8 1 0 0 1 1 1 1 XPG I-region XPG_I_2 PF12813.7 CCF48222.1 - 0.0004 19.9 0.0 0.00099 18.6 0.0 1.7 1 1 0 1 1 1 1 XPG domain containing BID PF06393.11 CCF48222.1 - 0.18 11.3 1.0 1.3 8.6 0.1 2.6 2 0 0 2 2 2 0 BH3 interacting domain (BID) MFS_1 PF07690.16 CCF48223.1 - 1.4e-44 152.5 45.6 6.6e-43 147.0 48.2 1.9 2 0 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 CCF48223.1 - 1.2e-24 86.7 30.7 8.3e-24 83.9 31.7 1.6 1 1 1 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 CCF48223.1 - 7.9e-11 41.5 10.1 7.9e-11 41.5 10.1 3.1 3 0 0 3 3 3 2 Sugar (and other) transporter DUF5337 PF17272.2 CCF48223.1 - 0.027 14.3 1.0 0.027 14.3 1.0 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5337) NDUF_B12 PF08122.12 CCF48223.1 - 0.12 12.4 3.3 4 7.6 0.0 3.6 4 0 0 4 4 4 0 NADH-ubiquinone oxidoreductase B12 subunit family DUF2370 PF10176.9 CCF48223.1 - 0.36 10.4 2.8 0.22 11.1 0.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2370) Flp_Fap PF04964.14 CCF48223.1 - 0.96 9.3 4.6 0.31 10.9 0.2 2.5 2 0 0 2 2 2 0 Flp/Fap pilin component Sds3 PF08598.11 CCF48224.1 - 9e-12 45.5 0.0 2e-11 44.3 0.0 1.6 2 0 0 2 2 2 1 Sds3-like Baculo_PP31 PF05311.11 CCF48224.1 - 0.0018 17.8 1.2 0.0018 17.8 1.2 2.2 2 0 0 2 2 2 2 Baculovirus 33KDa late protein (PP31) Cullin PF00888.22 CCF48225.1 - 2.3e-199 664.0 1.1 6.4e-199 662.6 1.1 1.7 1 1 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 CCF48225.1 - 4e-30 103.6 1.3 2.1e-29 101.4 1.6 2.1 2 0 0 2 2 2 1 Cullin protein neddylation domain HTH_IclR PF09339.10 CCF48225.1 - 0.00097 18.9 0.1 0.0039 16.9 0.1 2.1 2 0 0 2 2 2 1 IclR helix-turn-helix domain MarR_2 PF12802.7 CCF48225.1 - 0.01 15.7 0.1 4 7.4 0.0 2.7 2 0 0 2 2 2 2 MarR family PAZ PF02170.22 CCF48225.1 - 0.065 13.0 0.1 31 4.4 0.0 3.3 3 0 0 3 3 3 0 PAZ domain TrmB PF01978.19 CCF48225.1 - 0.067 13.1 0.0 1.1 9.1 0.0 2.5 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB Phage_rep_O PF04492.13 CCF48225.1 - 0.086 13.4 1.6 12 6.6 0.0 3.7 3 1 1 4 4 4 0 Bacteriophage replication protein O DUF3658 PF12395.8 CCF48225.1 - 0.088 12.7 0.6 0.3 11.0 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function DDRGK PF09756.9 CCF48225.1 - 0.16 11.5 6.0 0.092 12.3 0.8 2.5 2 0 0 2 2 2 0 DDRGK domain Opi1 PF08618.10 CCF48226.1 - 2.9e-101 339.7 5.8 2.9e-101 339.7 5.8 3.2 3 1 0 3 3 3 1 Transcription factor Opi1 REF PF05755.12 CCF48226.1 - 0.0096 15.8 0.0 0.02 14.7 0.0 1.4 1 0 0 1 1 1 1 Rubber elongation factor protein (REF) Perilipin PF03036.16 CCF48226.1 - 0.14 11.2 1.9 0.26 10.3 0.0 2.3 3 0 0 3 3 3 0 Perilipin family Pkinase PF00069.25 CCF48227.1 - 8.9e-30 103.9 0.0 3.3e-19 69.3 0.0 2.4 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CCF48227.1 - 2.8e-14 53.0 0.0 1.2e-08 34.5 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 CCF48227.1 - 0.0069 15.7 0.0 0.031 13.6 0.0 1.8 2 0 0 2 2 2 1 Kinase-like Hydantoinase_A PF01968.18 CCF48228.1 - 1.4e-98 329.8 1.0 2.6e-98 328.9 0.2 1.8 2 0 0 2 2 2 1 Hydantoinase/oxoprolinase Hydant_A_N PF05378.13 CCF48228.1 - 2.1e-56 190.4 0.0 7.4e-54 182.1 0.0 2.8 2 0 0 2 2 2 2 Hydantoinase/oxoprolinase N-terminal region GPI PF06560.11 CCF48228.1 - 0.15 11.4 0.0 0.31 10.3 0.0 1.5 1 0 0 1 1 1 0 Glucose-6-phosphate isomerase (GPI) MKT1_C PF12246.8 CCF48229.1 - 6.2e-76 254.8 0.0 1.2e-75 253.9 0.0 1.5 2 0 0 2 2 2 1 Temperature dependent protein affecting M2 dsRNA replication MKT1_N PF12247.8 CCF48229.1 - 4.2e-24 84.7 0.0 9.2e-24 83.6 0.0 1.6 1 0 0 1 1 1 1 Temperature dependent protein affecting M2 dsRNA replication XPG_N PF00752.17 CCF48229.1 - 5.3e-05 23.6 0.0 0.00013 22.4 0.0 1.7 1 1 0 1 1 1 1 XPG N-terminal domain zf-C3HC4_3 PF13920.6 CCF48231.1 - 3e-09 36.6 5.5 7.3e-09 35.4 5.5 1.6 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CCF48231.1 - 1.3e-05 24.9 3.4 2.2e-05 24.2 3.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CCF48231.1 - 0.00069 19.9 5.4 0.0014 18.9 5.4 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 CCF48231.1 - 0.00092 19.1 3.3 0.0015 18.4 3.3 1.3 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 CCF48231.1 - 0.0021 17.9 5.6 0.019 14.8 5.6 2.1 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 CCF48231.1 - 0.0046 16.9 3.6 0.02 14.9 1.7 2.3 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 CCF48231.1 - 0.063 13.1 5.5 0.039 13.8 2.0 2.1 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) DUF455 PF04305.14 CCF48232.1 - 5.4e-99 330.7 0.1 8e-99 330.2 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF455) Rieske PF00355.26 CCF48232.1 - 7.5e-07 29.0 0.1 1.4e-06 28.2 0.1 1.4 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain VPS9 PF02204.18 CCF48233.1 - 2.4e-15 56.6 0.0 5e-15 55.6 0.0 1.4 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain UBM PF14377.6 CCF48234.1 - 0.013 14.9 0.2 0.039 13.4 0.2 1.9 1 0 0 1 1 1 0 Ubiquitin binding region GATA PF00320.27 CCF48234.1 - 0.3 10.7 2.8 4.2 7.0 0.3 2.9 2 0 0 2 2 2 0 GATA zinc finger MFS_1 PF07690.16 CCF48235.1 - 2.4e-19 69.5 45.1 1e-16 60.8 16.4 2.4 2 0 0 2 2 2 2 Major Facilitator Superfamily MFS_4 PF06779.14 CCF48235.1 - 1.5e-05 24.5 0.8 1.5e-05 24.5 0.8 1.7 2 0 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB DUF2370 PF10176.9 CCF48235.1 - 0.022 14.4 1.2 0.052 13.2 1.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) MFS_1_like PF12832.7 CCF48235.1 - 0.44 9.3 14.3 2.5 6.9 0.2 3.1 2 1 0 2 2 2 0 MFS_1 like family DNA_pol_phi PF04931.13 CCF48235.1 - 9 4.3 5.4 13 3.7 5.4 1.1 1 0 0 1 1 1 0 DNA polymerase phi MFS_1 PF07690.16 CCF48237.1 - 3.8e-36 124.7 30.3 3.8e-36 124.7 30.3 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily DUF4231 PF14015.6 CCF48237.1 - 0.8 10.2 3.4 1.2 9.6 0.2 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF4231) ABC2_membrane_2 PF12679.7 CCF48237.1 - 8.9 5.5 10.2 2 7.6 1.5 2.6 2 0 0 2 2 2 0 ABC-2 family transporter protein F-box PF00646.33 CCF48238.1 - 0.0029 17.4 0.0 0.0064 16.3 0.0 1.5 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 CCF48238.1 - 0.004 17.0 0.1 0.015 15.1 0.1 1.9 1 0 0 1 1 1 1 F-box-like EF-hand_1 PF00036.32 CCF48239.1 - 3.5e-41 135.7 12.8 6.1e-10 37.9 1.0 4.2 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 CCF48239.1 - 1.5e-34 118.3 3.0 5.4e-18 65.2 1.3 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 CCF48239.1 - 1.3e-30 102.7 8.1 1.3e-09 37.2 0.1 4.2 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 CCF48239.1 - 1.4e-30 104.9 12.2 7.7e-15 54.5 0.8 4.0 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.6 CCF48239.1 - 1e-25 88.0 10.2 2.1e-06 27.0 0.1 4.3 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.6 CCF48239.1 - 5.2e-15 55.5 0.2 1.7e-08 34.7 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 CCF48239.1 - 5.3e-10 39.2 1.3 6.6e-05 22.8 0.3 2.3 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 CCF48239.1 - 2.2e-08 34.4 0.0 0.0012 19.2 0.1 2.1 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region UPF0154 PF03672.13 CCF48239.1 - 8.6e-06 25.7 0.0 0.13 12.3 0.0 3.1 2 1 1 3 3 3 2 Uncharacterised protein family (UPF0154) EF-hand_11 PF08976.11 CCF48239.1 - 1.8e-05 25.5 0.0 0.005 17.7 0.0 2.0 1 1 1 2 2 2 1 EF-hand domain Dockerin_1 PF00404.18 CCF48239.1 - 0.00022 21.3 6.2 0.034 14.3 0.9 3.1 1 1 2 3 3 3 2 Dockerin type I domain EFhand_Ca_insen PF08726.10 CCF48239.1 - 0.00044 20.3 0.5 0.0022 18.1 0.1 2.2 2 1 0 2 2 2 1 Ca2+ insensitive EF hand DUF1103 PF06513.11 CCF48239.1 - 0.0012 18.5 1.2 0.0014 18.3 1.2 1.1 1 0 0 1 1 1 1 Repeat of unknown function (DUF1103) DUF3349 PF11829.8 CCF48239.1 - 0.0013 19.4 0.2 1.2 10.0 0.0 2.8 1 1 2 3 3 3 1 Protein of unknown function (DUF3349) DUF4497 PF14924.6 CCF48239.1 - 0.0013 19.1 0.0 0.65 10.5 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF4497) Caleosin PF05042.13 CCF48239.1 - 0.0015 18.5 0.7 0.47 10.3 0.0 3.3 1 1 3 4 4 4 1 Caleosin related protein Poly_export PF02563.16 CCF48239.1 - 0.0032 17.6 0.1 0.43 10.8 0.0 2.9 1 1 1 2 2 2 1 Polysaccharide biosynthesis/export protein SapB_1 PF05184.15 CCF48239.1 - 0.0067 16.4 1.3 7.6 6.7 0.0 3.7 4 0 0 4 4 4 0 Saposin-like type B, region 1 DUF5580 PF17743.1 CCF48239.1 - 0.017 13.7 0.0 0.017 13.7 0.0 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5580) TerB PF05099.13 CCF48239.1 - 0.021 14.8 0.1 1.7 8.6 0.0 2.3 1 1 1 2 2 2 0 Tellurite resistance protein TerB MotA_activ PF09114.10 CCF48239.1 - 0.026 14.7 0.2 0.51 10.5 0.1 2.2 2 1 0 2 2 2 0 Transcription factor MotA, activation domain SurA_N_2 PF13623.6 CCF48239.1 - 0.04 13.8 0.4 0.69 9.8 0.1 2.2 1 1 1 2 2 2 0 SurA N-terminal domain RNA_pol_Rpb4 PF03874.16 CCF48239.1 - 0.064 13.6 0.1 9.6 6.6 0.0 2.6 3 0 0 3 3 3 0 RNA polymerase Rpb4 dCache_2 PF08269.11 CCF48239.1 - 0.07 12.3 0.1 0.92 8.6 0.1 2.1 1 1 1 2 2 2 0 Cache domain Fe_hyd_lg_C PF02906.14 CCF48239.1 - 0.075 12.7 0.1 0.13 11.9 0.1 1.5 1 1 0 1 1 1 0 Iron only hydrogenase large subunit, C-terminal domain DUF1811 PF08838.10 CCF48239.1 - 0.077 13.2 0.0 22 5.4 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1811) Spore_III_AB PF09548.10 CCF48239.1 - 0.1 12.7 0.2 0.17 12.0 0.2 1.5 1 1 0 1 1 1 0 Stage III sporulation protein AB (spore_III_AB) EF-hand_14 PF17959.1 CCF48239.1 - 0.1 12.9 0.1 17 5.8 0.0 2.4 1 1 1 2 2 2 0 EF-hand domain RloB PF13707.6 CCF48239.1 - 0.25 11.5 1.3 1.5 9.0 0.1 2.1 1 1 1 2 2 2 0 RloB-like protein Mito_carr PF00153.27 CCF48240.1 - 5.3e-62 205.8 7.6 2.5e-21 75.4 0.1 3.5 3 1 0 3 3 3 3 Mitochondrial carrier protein WD40 PF00400.32 CCF48241.1 - 1.3e-24 85.9 14.4 8.1e-06 26.5 0.1 6.7 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF48241.1 - 1.2e-16 60.8 5.3 5.2e-07 29.9 0.4 4.4 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 CCF48241.1 - 1.1e-05 25.4 1.1 0.00026 20.9 0.3 2.3 1 1 1 2 2 2 1 Eukaryotic translation initiation factor eIF2A HPP PF04982.13 CCF48242.1 - 1.7e-30 105.7 8.9 3.1e-30 104.8 8.9 1.5 1 0 0 1 1 1 1 HPP family Glycos_transf_4 PF00953.21 CCF48242.1 - 0.039 13.9 0.4 0.039 13.9 0.4 1.9 2 0 0 2 2 2 0 Glycosyl transferase family 4 zf-C2H2_assoc PF16606.5 CCF48242.1 - 0.2 11.9 11.6 0.043 14.0 2.8 2.7 2 0 0 2 2 2 0 Unstructured conserved, between two C2H2-type zinc-fingers Fis1_TPR_C PF14853.6 CCF48243.1 - 2.4e-24 85.1 0.7 3.9e-24 84.5 0.7 1.3 1 0 0 1 1 1 1 Fis1 C-terminal tetratricopeptide repeat Fis1_TPR_N PF14852.6 CCF48243.1 - 1.7e-15 56.3 0.0 3.1e-15 55.5 0.0 1.4 1 0 0 1 1 1 1 Fis1 N-terminal tetratricopeptide repeat TPR_2 PF07719.17 CCF48243.1 - 0.00036 20.4 0.2 0.001 19.0 0.2 1.9 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_6 PF13174.6 CCF48243.1 - 0.0065 17.0 0.3 0.029 15.0 0.0 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.6 CCF48243.1 - 0.036 14.6 1.2 0.046 14.2 0.0 1.8 2 0 0 2 2 2 0 Tetratricopeptide repeat COPI_C PF06957.11 CCF48243.1 - 0.13 10.9 0.1 0.36 9.5 0.0 1.6 2 0 0 2 2 2 0 Coatomer (COPI) alpha subunit C-terminus PX PF00787.24 CCF48244.1 - 1.2e-21 76.8 0.2 3e-21 75.5 0.2 1.7 1 0 0 1 1 1 1 PX domain Vps5 PF09325.10 CCF48244.1 - 4.4e-08 33.0 4.1 7.8e-05 22.3 1.5 2.3 2 0 0 2 2 2 2 Vps5 C terminal like FliJ PF02050.16 CCF48244.1 - 0.023 14.9 0.9 0.86 9.8 0.0 2.4 2 0 0 2 2 2 0 Flagellar FliJ protein ABC_tran_CTD PF16326.5 CCF48244.1 - 0.025 14.8 0.4 0.85 9.9 0.1 2.7 2 0 0 2 2 2 0 ABC transporter C-terminal domain DUF1513 PF07433.11 CCF48244.1 - 0.034 13.2 0.2 0.33 10.0 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1513) EzrA PF06160.12 CCF48244.1 - 0.13 10.4 0.6 0.19 9.9 0.1 1.4 2 0 0 2 2 2 0 Septation ring formation regulator, EzrA MerR-DNA-bind PF09278.11 CCF48244.1 - 0.29 11.7 5.5 1.3 9.6 0.0 3.6 4 0 0 4 4 4 0 MerR, DNA binding NUDE_C PF04880.13 CCF48244.1 - 1.6 9.2 7.8 5.5 7.4 4.5 2.4 2 0 0 2 2 2 0 NUDE protein, C-terminal conserved region Clathrin PF00637.20 CCF48245.1 - 9.6e-205 670.7 37.8 9.6e-34 116.3 0.1 7.8 8 0 0 8 8 8 7 Region in Clathrin and VPS Clathrin_propel PF01394.20 CCF48245.1 - 1.5e-36 122.9 0.6 3.7e-08 33.3 0.1 6.6 6 0 0 6 6 6 6 Clathrin propeller repeat Clathrin_H_link PF13838.6 CCF48245.1 - 3.1e-32 110.3 1.3 1.7e-31 107.9 0.2 2.9 3 0 0 3 3 3 1 Clathrin-H-link Clathrin-link PF09268.10 CCF48245.1 - 1.1e-09 37.4 0.2 1.1e-09 37.4 0.2 2.5 2 0 0 2 2 2 1 Clathrin, heavy-chain linker TPR_14 PF13428.6 CCF48245.1 - 0.00088 19.9 12.8 8.1 7.6 0.2 9.0 9 1 0 9 9 9 1 Tetratricopeptide repeat Coatomer_WDAD PF04053.14 CCF48245.1 - 0.0058 15.7 12.6 0.2 10.6 0.1 5.0 6 0 0 6 6 6 2 Coatomer WD associated region TPR_1 PF00515.28 CCF48245.1 - 0.01 15.7 7.6 11 6.0 0.2 5.2 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_2 PF07719.17 CCF48245.1 - 0.016 15.3 10.4 3.3 8.0 0.1 6.1 5 0 0 5 5 5 0 Tetratricopeptide repeat Vps39_1 PF10366.9 CCF48245.1 - 0.035 14.4 8.0 4.4 7.6 0.0 5.5 5 1 0 5 5 5 0 Vacuolar sorting protein 39 domain 1 HNOBA PF07701.14 CCF48245.1 - 0.11 11.9 0.0 0.21 11.0 0.0 1.3 1 0 0 1 1 1 0 Heme NO binding associated AAA PF00004.29 CCF48246.1 - 4.5e-43 146.8 0.0 7.6e-43 146.1 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 CCF48246.1 - 1.1e-10 41.2 0.1 2.2e-10 40.1 0.1 1.5 1 0 0 1 1 1 1 AAA+ lid domain Prot_ATP_ID_OB PF16450.5 CCF48246.1 - 7.4e-10 38.6 0.1 1.5e-09 37.7 0.1 1.5 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_16 PF13191.6 CCF48246.1 - 4.1e-07 30.5 0.0 0.00018 21.9 0.1 2.8 2 1 0 3 3 3 1 AAA ATPase domain AAA_5 PF07728.14 CCF48246.1 - 8.1e-07 29.1 0.1 1.7e-05 24.8 0.1 2.6 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 CCF48246.1 - 8.7e-07 29.2 0.0 5.7e-06 26.6 0.0 2.1 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 CCF48246.1 - 7.8e-06 25.7 0.0 1.8e-05 24.5 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 CCF48246.1 - 0.00018 21.8 0.1 0.005 17.1 0.0 2.5 1 1 1 2 2 2 1 AAA domain DUF815 PF05673.13 CCF48246.1 - 0.0008 18.6 0.0 0.0021 17.3 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_18 PF13238.6 CCF48246.1 - 0.00081 19.9 0.3 0.007 16.9 0.0 2.6 3 1 0 3 3 3 1 AAA domain AAA_24 PF13479.6 CCF48246.1 - 0.0013 18.5 0.1 0.018 14.8 0.0 2.7 3 0 0 3 3 3 1 AAA domain AAA_7 PF12775.7 CCF48246.1 - 0.0016 18.0 0.0 0.0035 16.9 0.0 1.6 1 0 0 1 1 1 1 P-loop containing dynein motor region Mg_chelatase PF01078.21 CCF48246.1 - 0.003 17.0 0.0 0.006 16.0 0.0 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI TIP49 PF06068.13 CCF48246.1 - 0.0033 16.7 0.0 0.0066 15.7 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_14 PF13173.6 CCF48246.1 - 0.0053 16.8 0.1 0.015 15.4 0.0 1.7 2 0 0 2 2 1 1 AAA domain RNA_helicase PF00910.22 CCF48246.1 - 0.006 16.9 0.0 0.012 16.0 0.0 1.5 1 0 0 1 1 1 1 RNA helicase TsaE PF02367.17 CCF48246.1 - 0.0061 16.6 0.0 0.011 15.7 0.0 1.4 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_33 PF13671.6 CCF48246.1 - 0.0073 16.5 0.0 0.015 15.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 CCF48246.1 - 0.008 15.9 0.0 0.016 14.9 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein Sigma54_activat PF00158.26 CCF48246.1 - 0.0089 15.7 0.0 0.029 14.1 0.0 1.9 1 1 0 1 1 1 1 Sigma-54 interaction domain AAA_3 PF07726.11 CCF48246.1 - 0.014 15.2 0.0 0.029 14.2 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 CCF48246.1 - 0.029 14.1 0.0 0.07 12.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain ATPase PF06745.13 CCF48246.1 - 0.037 13.4 0.1 0.18 11.1 0.0 2.1 2 0 0 2 2 2 0 KaiC NACHT PF05729.12 CCF48246.1 - 0.039 13.9 0.0 0.093 12.6 0.0 1.6 1 0 0 1 1 1 0 NACHT domain GAS PF13851.6 CCF48246.1 - 0.045 13.1 2.4 0.08 12.3 2.4 1.3 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding AAA_28 PF13521.6 CCF48246.1 - 0.054 13.7 0.0 0.11 12.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 CCF48246.1 - 0.061 12.8 0.0 0.13 11.8 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein AAA_11 PF13086.6 CCF48246.1 - 0.062 13.1 0.3 0.34 10.7 0.0 2.1 2 0 0 2 2 2 0 AAA domain Parvo_NS1 PF01057.17 CCF48246.1 - 0.082 12.0 0.0 0.14 11.2 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 CPT PF07931.12 CCF48246.1 - 0.1 12.4 0.0 0.3 10.9 0.0 1.7 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein Prot_ATP_OB_N PF17758.1 CCF48246.1 - 0.12 12.1 0.0 0.25 11.0 0.0 1.5 1 0 0 1 1 1 0 Proteasomal ATPase OB N-terminal domain AAA_23 PF13476.6 CCF48246.1 - 0.13 12.7 4.0 13 6.3 3.3 2.4 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 CCF48246.1 - 0.16 11.6 0.1 0.35 10.4 0.1 1.5 1 0 0 1 1 1 0 AAA domain CENP-Q PF13094.6 CCF48246.1 - 0.19 12.0 2.1 1.6 8.9 0.6 2.5 3 0 0 3 3 2 0 CENP-Q, a CENPA-CAD centromere complex subunit TPR_1 PF00515.28 CCF48246.1 - 8.6 6.4 6.6 0.67 9.9 0.8 2.2 3 0 0 3 3 2 0 Tetratricopeptide repeat GPI-anchored PF10342.9 CCF48247.1 - 9.2e-07 29.5 0.2 1.8e-06 28.6 0.2 1.5 1 1 0 1 1 1 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family DUF4448 PF14610.6 CCF48247.1 - 0.095 12.5 0.0 0.11 12.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) CBM_5_12 PF02839.14 CCF48247.1 - 5.8 7.7 5.7 0.6 10.8 0.7 2.0 2 0 0 2 2 2 0 Carbohydrate binding domain PRP38_assoc PF12871.7 CCF48248.1 - 3.2 8.4 16.1 5.9 7.6 15.6 1.7 1 1 0 1 1 1 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term DUF3942 PF13078.6 CCF48249.1 - 0.1 12.9 4.3 0.65 10.3 0.1 3.5 2 2 2 4 4 4 0 Protein of unknown function (DUF3942) Zn_clus PF00172.18 CCF48250.1 - 4.1e-05 23.6 7.5 7.7e-05 22.7 7.5 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SOXp PF12336.8 CCF48250.1 - 0.78 10.8 4.3 73 4.5 1.3 3.8 3 0 0 3 3 3 0 SOX transcription factor Methyltransf_10 PF05971.12 CCF48251.1 - 3.8e-48 164.4 0.0 6.6e-48 163.6 0.0 1.3 1 0 0 1 1 1 1 RNA methyltransferase Methyltransf_12 PF08242.12 CCF48251.1 - 0.0036 18.0 0.0 0.047 14.4 0.0 2.6 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF48251.1 - 0.15 12.8 0.0 0.38 11.5 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain CENP-O PF09496.10 CCF48252.1 - 6.9e-32 111.2 0.0 1e-31 110.6 0.0 1.3 1 0 0 1 1 1 1 Cenp-O kinetochore centromere component Pkinase PF00069.25 CCF48254.1 - 2.7e-66 223.7 0.0 4.1e-66 223.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF48254.1 - 2.6e-34 118.7 0.0 4.3e-34 118.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Fungal_KA1 PF16797.5 CCF48254.1 - 0.0037 16.9 0.1 0.045 13.5 0.0 2.4 2 0 0 2 2 2 1 Fungal kinase associated-1 domain Kdo PF06293.14 CCF48254.1 - 0.006 16.0 0.0 0.011 15.1 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CCF48254.1 - 0.008 16.1 0.0 0.032 14.2 0.0 1.9 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.6 CCF48254.1 - 0.014 14.7 0.0 0.033 13.5 0.0 1.6 1 0 0 1 1 1 0 Kinase-like Choline_kinase PF01633.20 CCF48254.1 - 0.035 13.7 0.7 0.071 12.7 0.1 1.7 2 0 0 2 2 2 0 Choline/ethanolamine kinase RIO1 PF01163.22 CCF48254.1 - 0.13 11.8 0.0 0.37 10.4 0.0 1.6 1 1 0 1 1 1 0 RIO1 family Histone PF00125.24 CCF48255.1 - 4.7e-51 172.6 2.5 5.2e-51 172.4 2.5 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.6 CCF48255.1 - 1e-05 25.8 0.0 1.6e-05 25.2 0.0 1.2 1 0 0 1 1 1 1 CENP-S protein CENP-T_C PF15511.6 CCF48255.1 - 6.5e-05 23.0 0.5 9.9e-05 22.4 0.1 1.5 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold PAF PF15715.5 CCF48255.1 - 0.00045 20.8 1.6 0.00055 20.5 1.6 1.1 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CBFD_NFYB_HMF PF00808.23 CCF48255.1 - 0.0019 18.5 0.1 0.0036 17.6 0.1 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Bromo_TP PF07524.13 CCF48255.1 - 0.022 14.8 0.0 0.035 14.1 0.0 1.4 1 0 0 1 1 1 0 Bromodomain associated TFIID-31kDa PF02291.15 CCF48255.1 - 0.074 13.1 0.2 0.12 12.4 0.0 1.5 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit zinc_ribbon_10 PF10058.9 CCF48256.1 - 6.4e-18 64.2 0.2 1.1e-17 63.5 0.2 1.4 1 0 0 1 1 1 1 Predicted integral membrane zinc-ribbon metal-binding protein Mu-like_Com PF10122.9 CCF48256.1 - 0.0098 15.3 0.1 0.022 14.2 0.1 1.5 1 0 0 1 1 1 1 Mu-like prophage protein Com MSA-2c PF12238.8 CCF48256.1 - 0.02 14.9 0.8 0.02 14.9 0.8 1.9 2 0 0 2 2 2 0 Merozoite surface antigen 2c PknG_rubred PF16919.5 CCF48256.1 - 0.059 13.5 1.2 0.22 11.7 1.2 2.0 1 1 0 1 1 1 0 Protein kinase G rubredoxin domain UcrQ PF02939.16 CCF48257.1 - 4.1e-32 109.9 1.7 5.1e-32 109.6 1.7 1.1 1 0 0 1 1 1 1 UcrQ family Cyt_b-c1_8 PF10890.8 CCF48257.1 - 0.0096 16.3 0.1 0.014 15.8 0.1 1.4 1 0 0 1 1 1 1 Cytochrome b-c1 complex subunit 8 CNH PF00780.22 CCF48258.1 - 1.2e-80 271.1 0.0 1.8e-80 270.5 0.0 1.2 1 0 0 1 1 1 1 CNH domain PH_5 PF15405.6 CCF48258.1 - 8.2e-48 161.9 0.0 1.9e-47 160.8 0.0 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain RhoGEF PF00621.20 CCF48258.1 - 3.3e-37 128.5 0.2 6.2e-37 127.6 0.2 1.5 1 0 0 1 1 1 1 RhoGEF domain DEP PF00610.21 CCF48258.1 - 2.7e-14 52.9 0.0 5.3e-14 52.0 0.0 1.5 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) PH_13 PF16652.5 CCF48258.1 - 0.0027 17.5 0.5 0.014 15.2 0.1 2.3 2 1 0 2 2 2 1 Pleckstrin homology domain SGP PF17228.2 CCF48258.1 - 0.0098 16.7 12.8 0.0098 16.7 12.8 4.4 4 0 0 4 4 4 1 Sulphur globule protein GRP PF07172.11 CCF48258.1 - 5.2 7.8 21.3 13 6.6 21.3 1.6 1 0 0 1 1 1 0 Glycine rich protein family HIG_1_N PF04588.13 CCF48259.1 - 2.8e-07 30.7 0.8 5.2e-07 29.8 0.8 1.5 1 0 0 1 1 1 1 Hypoxia induced protein conserved region DUF3069 PF11269.8 CCF48260.1 - 0.11 12.7 0.5 1.4 9.2 0.1 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3069) ETC_C1_NDUFA5 PF04716.14 CCF48261.1 - 2.6e-17 62.4 5.6 3.1e-17 62.1 3.7 2.1 2 1 0 2 2 2 1 ETC complex I subunit conserved region Mu-like_Pro PF10123.9 CCF48261.1 - 0.008 15.8 1.7 0.0088 15.6 1.7 1.1 1 0 0 1 1 1 1 Mu-like prophage I protein T2SSM PF04612.12 CCF48261.1 - 0.034 14.2 7.1 0.076 13.1 5.2 2.0 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein M PspA_IM30 PF04012.12 CCF48261.1 - 0.039 13.5 8.4 0.053 13.1 8.4 1.2 1 0 0 1 1 1 0 PspA/IM30 family WW PF00397.26 CCF48262.1 - 1.6e-09 37.7 3.5 2.8e-09 36.9 3.5 1.4 1 0 0 1 1 1 1 WW domain DUF2076 PF09849.9 CCF48262.1 - 2 8.4 33.4 0.057 13.5 16.5 2.5 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2076) Sel1 PF08238.12 CCF48263.1 - 4.4e-45 151.1 23.5 1.9e-07 31.5 0.0 8.7 8 0 0 8 8 8 8 Sel1 repeat DAO PF01266.24 CCF48264.1 - 3.6e-36 125.5 0.0 7.7e-36 124.4 0.0 1.5 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CCF48264.1 - 7.8e-09 35.2 0.0 0.00089 18.6 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 CCF48264.1 - 1.6e-08 34.1 0.6 1.1e-05 24.7 0.1 2.2 2 0 0 2 2 2 2 FAD binding domain GIDA PF01134.22 CCF48264.1 - 3.9e-07 29.5 0.0 0.0044 16.2 0.0 2.2 2 0 0 2 2 2 2 Glucose inhibited division protein A Pyr_redox PF00070.27 CCF48264.1 - 1.8e-06 28.4 0.1 0.026 15.1 0.0 2.6 3 0 0 3 3 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CCF48264.1 - 6.9e-06 26.2 0.0 1.7e-05 24.9 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 CCF48264.1 - 3.1e-05 24.0 0.2 0.13 12.2 0.2 2.4 2 0 0 2 2 2 2 FAD-NAD(P)-binding HI0933_like PF03486.14 CCF48264.1 - 4.3e-05 22.4 0.0 0.011 14.5 0.0 2.8 3 0 0 3 3 3 1 HI0933-like protein 3HCDH_N PF02737.18 CCF48264.1 - 0.0017 18.3 0.0 0.0033 17.3 0.0 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain FAD_binding_3 PF01494.19 CCF48264.1 - 0.0027 17.0 0.0 0.054 12.7 0.0 2.4 3 0 0 3 3 3 1 FAD binding domain Trp_halogenase PF04820.14 CCF48264.1 - 0.0027 16.6 0.0 0.022 13.6 0.0 2.0 2 0 0 2 2 2 1 Tryptophan halogenase Thi4 PF01946.17 CCF48264.1 - 0.006 15.8 0.0 0.012 14.9 0.0 1.4 1 0 0 1 1 1 1 Thi4 family 2-Hacid_dh_C PF02826.19 CCF48264.1 - 0.0076 15.6 0.0 0.13 11.6 0.0 2.3 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.21 CCF48264.1 - 0.008 15.5 0.0 0.017 14.4 0.0 1.6 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox_3 PF13738.6 CCF48264.1 - 0.0089 15.3 0.0 0.97 8.6 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 CCF48264.1 - 0.01 14.9 0.1 0.3 10.1 0.0 2.1 2 0 0 2 2 2 0 Lycopene cyclase protein Amino_oxidase PF01593.24 CCF48264.1 - 0.027 13.8 0.1 0.086 12.1 0.0 1.8 3 0 0 3 3 3 0 Flavin containing amine oxidoreductase ApbA PF02558.16 CCF48264.1 - 0.062 12.9 0.0 0.13 12.0 0.0 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA HA2 PF04408.23 CCF48265.1 - 4.5e-25 88.0 1.4 9.5e-25 87.0 0.1 2.2 2 0 0 2 2 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 CCF48265.1 - 6.5e-20 71.3 0.0 1.4e-19 70.2 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 CCF48265.1 - 5.4e-14 52.5 0.0 1.3e-13 51.2 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain S1 PF00575.23 CCF48265.1 - 1e-07 32.2 0.1 2.1e-07 31.2 0.1 1.6 1 0 0 1 1 1 1 S1 RNA binding domain AAA_30 PF13604.6 CCF48265.1 - 6.6e-05 22.7 0.2 0.0015 18.2 0.0 2.4 2 0 0 2 2 2 1 AAA domain DEAD PF00270.29 CCF48265.1 - 0.00016 21.5 0.1 0.00016 21.5 0.1 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase AAA_22 PF13401.6 CCF48265.1 - 0.00042 20.6 0.0 0.0011 19.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 CCF48265.1 - 0.00063 18.9 0.0 0.002 17.3 0.0 1.8 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_19 PF13245.6 CCF48265.1 - 0.0041 17.5 0.3 0.014 15.7 0.1 2.0 2 0 0 2 2 2 1 AAA domain ABC_tran PF00005.27 CCF48265.1 - 0.0053 17.3 0.2 1 9.9 0.1 3.3 2 1 0 2 2 2 1 ABC transporter Microtub_bd PF16796.5 CCF48265.1 - 0.017 15.1 0.0 0.14 12.1 0.0 2.2 2 0 0 2 2 2 0 Microtubule binding Flavi_DEAD PF07652.14 CCF48265.1 - 0.044 13.7 0.0 0.093 12.7 0.0 1.5 1 0 0 1 1 1 0 Flavivirus DEAD domain PhoH PF02562.16 CCF48265.1 - 0.052 13.0 0.0 0.14 11.5 0.0 1.7 1 0 0 1 1 1 0 PhoH-like protein DAGAT PF03982.13 CCF48266.1 - 2.7e-105 351.5 0.0 3.4e-105 351.2 0.0 1.0 1 0 0 1 1 1 1 Diacylglycerol acyltransferase CS PF04969.16 CCF48267.1 - 0.00022 22.2 0.0 0.00048 21.1 0.0 1.6 2 0 0 2 2 2 1 CS domain Forkhead_N PF08430.12 CCF48267.1 - 6.5 7.4 18.5 11 6.6 18.5 1.3 1 0 0 1 1 1 0 Forkhead N-terminal region RRM_1 PF00076.22 CCF48268.1 - 6e-16 58.0 0.0 1.9e-15 56.4 0.0 2.0 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nop14 PF04147.12 CCF48268.1 - 0.00013 20.4 17.1 0.00013 20.4 17.1 1.8 2 0 0 2 2 2 1 Nop14-like family RL PF17797.1 CCF48268.1 - 0.0019 18.1 0.1 0.0046 16.9 0.1 1.6 1 0 0 1 1 1 1 RL domain RRM_5 PF13893.6 CCF48268.1 - 0.018 14.6 0.0 0.035 13.7 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF2782 PF11191.8 CCF48268.1 - 0.082 13.1 0.0 0.3 11.3 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2782) DUF4551 PF15087.6 CCF48268.1 - 0.65 8.8 7.2 0.92 8.3 7.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) RNA_pol_3_Rpc31 PF11705.8 CCF48268.1 - 1.2 9.4 29.2 0.14 12.4 22.8 2.2 2 0 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 GREB1 PF15782.5 CCF48268.1 - 5.5 4.0 12.1 7.2 3.6 12.1 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer NUDIX PF00293.28 CCF48269.1 - 1.5e-08 34.7 0.0 2.4e-08 34.1 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain DUF3218 PF11508.8 CCF48269.1 - 0.038 13.5 0.0 0.061 12.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3218) FAD_binding_3 PF01494.19 CCF48269.1 - 0.072 12.3 0.1 0.11 11.7 0.1 1.2 1 0 0 1 1 1 0 FAD binding domain Pro_isomerase PF00160.21 CCF48270.1 - 2.1e-35 122.3 0.0 5.1e-35 121.1 0.0 1.7 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Glyco_hydro_63 PF03200.16 CCF48271.1 - 4.3e-08 32.3 4.5 7e-06 25.1 0.1 4.5 4 1 0 4 4 4 2 Glycosyl hydrolase family 63 C-terminal domain Methyltransf_16 PF10294.9 CCF48272.1 - 5.7e-18 65.3 0.0 3.4e-08 33.4 0.0 2.1 1 1 1 2 2 2 2 Lysine methyltransferase RrnaAD PF00398.20 CCF48272.1 - 0.00099 18.3 0.0 0.0014 17.8 0.0 1.1 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase BIRC6 PF12356.8 CCF48272.1 - 0.031 13.7 0.0 0.048 13.1 0.0 1.3 1 0 0 1 1 1 0 Baculoviral IAP repeat-containing protein 6 PH PF00169.29 CCF48273.1 - 0.001 19.5 0.3 2.8 8.5 0.0 3.0 3 0 0 3 3 3 2 PH domain PH_9 PF15410.6 CCF48273.1 - 0.049 14.0 0.1 0.25 11.7 0.0 2.3 2 0 0 2 2 2 0 Pleckstrin homology domain NOA36 PF06524.12 CCF48273.1 - 0.46 9.8 3.8 0.81 9.0 3.8 1.3 1 0 0 1 1 1 0 NOA36 protein Pox_Ag35 PF03286.14 CCF48273.1 - 0.64 9.8 3.3 1.6 8.5 3.3 1.6 1 0 0 1 1 1 0 Pox virus Ag35 surface protein VHS PF00790.19 CCF48274.1 - 3.1e-32 111.3 1.1 3.5e-32 111.2 0.2 1.5 2 0 0 2 2 2 1 VHS domain SH3_1 PF00018.28 CCF48274.1 - 1.4e-15 56.6 0.0 2.6e-15 55.7 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 CCF48274.1 - 6.8e-14 51.5 0.1 1.4e-13 50.5 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 CCF48274.1 - 1.8e-11 43.5 0.1 3.1e-11 42.8 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain GAT PF03127.14 CCF48274.1 - 6.3e-09 36.0 0.9 1.6e-08 34.8 0.9 1.7 1 0 0 1 1 1 1 GAT domain Hrs_helical PF12210.8 CCF48274.1 - 0.00085 19.8 0.7 0.0021 18.5 0.7 1.6 1 0 0 1 1 1 1 Hepatocyte growth factor-regulated tyrosine kinase substrate UIM PF02809.20 CCF48274.1 - 0.0051 16.7 2.7 0.0051 16.7 2.7 2.4 2 0 0 2 2 2 1 Ubiquitin interaction motif Cyt-b5 PF00173.28 CCF48275.1 - 5.7e-19 68.0 0.0 9.1e-19 67.4 0.0 1.3 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain DASH_Spc34 PF08657.10 CCF48276.1 - 5.6e-05 23.1 2.6 9.3e-05 22.3 5.2 3.7 1 1 2 4 4 4 2 DASH complex subunit Spc34 A_deaminase PF00962.22 CCF48277.1 - 1.1e-120 402.9 0.1 1.6e-120 402.4 0.1 1.2 1 0 0 1 1 1 1 Adenosine/AMP deaminase Rep_fac_C PF08542.11 CCF48278.1 - 2e-22 79.4 0.1 4e-22 78.4 0.1 1.6 1 0 0 1 1 1 1 Replication factor C C-terminal domain AAA PF00004.29 CCF48278.1 - 1e-16 61.6 0.0 2.2e-16 60.5 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.6 CCF48278.1 - 2.1e-15 56.9 0.0 8.4e-11 41.9 0.0 2.3 1 1 1 2 2 2 2 DNA polymerase III, delta subunit Rad17 PF03215.15 CCF48278.1 - 2.4e-10 40.6 0.0 7.4e-10 39.0 0.0 1.8 1 1 0 1 1 1 1 Rad17 P-loop domain AAA_assoc_2 PF16193.5 CCF48278.1 - 1.1e-05 25.7 0.1 5e-05 23.6 0.0 2.3 2 0 0 2 2 2 1 AAA C-terminal domain AAA_24 PF13479.6 CCF48278.1 - 5.3e-05 23.0 0.0 0.00012 21.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.12 CCF48278.1 - 8.9e-05 22.3 0.0 0.00023 20.9 0.0 1.7 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_11 PF13086.6 CCF48278.1 - 0.00011 22.1 0.1 0.00085 19.2 0.0 2.1 1 1 1 2 2 2 1 AAA domain AAA_22 PF13401.6 CCF48278.1 - 0.00029 21.1 0.1 0.12 12.7 0.1 3.0 2 1 0 2 2 2 1 AAA domain AAA_30 PF13604.6 CCF48278.1 - 0.0004 20.2 0.0 0.0018 18.0 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 CCF48278.1 - 0.00046 20.6 0.0 0.0017 18.7 0.0 1.9 1 1 0 1 1 1 1 AAA ATPase domain DUF815 PF05673.13 CCF48278.1 - 0.00068 18.9 0.0 0.001 18.3 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_5 PF07728.14 CCF48278.1 - 0.00076 19.5 0.0 0.0038 17.2 0.0 2.2 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_14 PF13173.6 CCF48278.1 - 0.0023 18.0 0.0 0.0051 16.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain DNA_pol3_delta PF06144.13 CCF48278.1 - 0.0024 17.7 0.0 0.004 16.9 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase III, delta subunit AAA_7 PF12775.7 CCF48278.1 - 0.0057 16.2 0.0 0.012 15.1 0.0 1.6 1 0 0 1 1 1 1 P-loop containing dynein motor region WGG PF10273.9 CCF48278.1 - 0.007 17.0 0.0 0.46 11.2 0.0 2.4 2 0 0 2 2 2 1 Pre-rRNA-processing protein TSR2 ResIII PF04851.15 CCF48278.1 - 0.008 16.2 0.0 0.14 12.2 0.0 2.2 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit TniB PF05621.11 CCF48278.1 - 0.013 14.9 0.0 0.34 10.3 0.0 2.3 1 1 1 2 2 2 0 Bacterial TniB protein Mg_chelatase PF01078.21 CCF48278.1 - 0.028 13.8 0.0 0.16 11.3 0.0 2.0 1 1 1 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_19 PF13245.6 CCF48278.1 - 0.029 14.7 0.3 0.32 11.3 0.0 2.2 2 1 1 3 3 3 0 AAA domain IstB_IS21 PF01695.17 CCF48278.1 - 0.043 13.6 0.0 0.1 12.3 0.0 1.6 1 1 0 1 1 1 0 IstB-like ATP binding protein Viral_helicase1 PF01443.18 CCF48278.1 - 0.047 13.4 0.0 0.084 12.6 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_18 PF13238.6 CCF48278.1 - 0.05 14.2 0.0 2.6 8.6 0.0 2.3 2 0 0 2 2 2 0 AAA domain DEAD PF00270.29 CCF48278.1 - 0.051 13.3 0.1 0.38 10.5 0.0 2.2 1 1 1 2 2 2 0 DEAD/DEAH box helicase AAA_3 PF07726.11 CCF48278.1 - 0.059 13.2 0.0 0.16 11.8 0.0 1.7 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.6 CCF48278.1 - 0.069 12.7 0.0 0.19 11.3 0.0 1.8 1 1 0 1 1 1 0 AAA domain AAA_28 PF13521.6 CCF48278.1 - 0.12 12.6 0.0 0.23 11.7 0.0 1.6 1 1 0 1 1 1 0 AAA domain Nucleopor_Nup85 PF07575.13 CCF48279.1 - 9.6e-87 291.9 0.0 1.3e-51 175.9 0.0 2.4 2 1 0 2 2 2 2 Nup85 Nucleoporin zf-C2H2_jaz PF12171.8 CCF48280.1 - 4.6e-09 36.3 1.6 7.4e-09 35.7 1.6 1.4 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 CCF48280.1 - 0.0011 19.3 0.5 0.0011 19.3 0.5 1.5 1 1 0 1 1 1 1 C2H2 type zinc-finger (2 copies) zf-met PF12874.7 CCF48280.1 - 0.0012 19.2 1.0 0.0019 18.5 1.0 1.4 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2 PF00096.26 CCF48280.1 - 0.012 16.0 1.5 0.012 16.0 1.5 1.9 2 0 0 2 2 2 0 Zinc finger, C2H2 type DnaJ PF00226.31 CCF48280.1 - 0.052 13.7 0.4 0.1 12.7 0.4 1.5 1 0 0 1 1 1 0 DnaJ domain zf-C2H2_4 PF13894.6 CCF48280.1 - 0.087 13.7 0.6 0.087 13.7 0.6 1.8 2 0 0 2 2 2 0 C2H2-type zinc finger Ribosomal_L35Ae PF01247.18 CCF48281.1 - 1.1e-43 147.2 1.1 1.3e-43 147.1 1.1 1.0 1 0 0 1 1 1 1 Ribosomal protein L35Ae RimM PF01782.18 CCF48281.1 - 0.0075 16.5 0.0 0.66 10.2 0.0 2.2 2 0 0 2 2 2 2 RimM N-terminal domain DUF1746 PF08508.10 CCF48282.1 - 2.6e-23 82.5 9.7 3.6e-23 82.1 9.7 1.2 1 0 0 1 1 1 1 Fungal domain of unknown function (DUF1746) Scm3 PF10384.9 CCF48283.1 - 6.5e-17 61.0 0.6 1.8e-15 56.4 0.2 2.8 2 0 0 2 2 2 1 Centromere protein Scm3 DUF769 PF05590.11 CCF48283.1 - 0.089 12.2 0.0 0.15 11.5 0.0 1.3 1 0 0 1 1 1 0 Xylella fastidiosa protein of unknown function (DUF769) dsrm PF00035.26 CCF48284.1 - 1.8e-06 28.5 0.0 4e-06 27.4 0.0 1.5 1 0 0 1 1 1 1 Double-stranded RNA binding motif DND1_DSRM PF14709.7 CCF48284.1 - 0.034 14.4 0.0 0.071 13.4 0.0 1.5 1 0 0 1 1 1 0 double strand RNA binding domain from DEAD END PROTEIN 1 ACC_central PF08326.12 CCF48285.1 - 1.5e-214 714.4 0.0 2.2e-214 713.9 0.0 1.2 1 0 0 1 1 1 1 Acetyl-CoA carboxylase, central region Carboxyl_trans PF01039.22 CCF48285.1 - 3.2e-177 590.1 0.0 4.3e-177 589.7 0.0 1.2 1 0 0 1 1 1 1 Carboxyl transferase domain CPSase_L_D2 PF02786.17 CCF48285.1 - 3.1e-53 180.4 0.0 6e-53 179.5 0.0 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.22 CCF48285.1 - 1e-27 96.8 0.1 2.7e-27 95.5 0.1 1.8 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 CCF48285.1 - 3.2e-21 75.4 0.0 9.7e-20 70.7 0.0 2.8 3 0 0 3 3 2 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.22 CCF48285.1 - 1.3e-14 53.8 0.2 2.7e-14 52.7 0.2 1.6 1 0 0 1 1 1 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.6 CCF48285.1 - 3.2e-07 30.1 0.0 1.6e-06 27.9 0.0 2.2 1 0 0 1 1 1 1 Biotin-lipoyl like ATP-grasp PF02222.22 CCF48285.1 - 0.00017 21.2 0.0 0.0004 20.0 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain RimK PF08443.11 CCF48285.1 - 0.0027 17.3 0.0 0.0082 15.8 0.0 1.8 1 1 0 1 1 1 1 RimK-like ATP-grasp domain Dala_Dala_lig_C PF07478.13 CCF48285.1 - 0.016 14.7 0.0 0.061 12.8 0.0 2.0 2 0 0 2 2 2 0 D-ala D-ala ligase C-terminus RnfC_N PF13375.6 CCF48285.1 - 0.02 14.8 0.0 0.061 13.3 0.0 1.8 1 0 0 1 1 1 0 RnfC Barrel sandwich hybrid domain ATP-grasp_3 PF02655.14 CCF48285.1 - 0.026 14.6 0.0 0.081 13.0 0.0 1.8 1 0 0 1 1 1 0 ATP-grasp domain ERCC4 PF02732.15 CCF48286.1 - 8.5e-21 74.8 0.0 1.6e-20 73.9 0.0 1.5 1 0 0 1 1 1 1 ERCC4 domain HHH_8 PF14716.6 CCF48286.1 - 1.8e-05 25.0 0.1 0.00017 21.9 0.0 2.4 2 0 0 2 2 2 1 Helix-hairpin-helix domain Cytochrom_C1 PF02167.15 CCF48287.1 - 1.6e-97 325.5 0.0 2.1e-97 325.1 0.0 1.2 1 0 0 1 1 1 1 Cytochrome C1 family Cytochrome_CBB3 PF13442.6 CCF48287.1 - 0.0013 19.0 0.0 0.0026 18.0 0.0 1.6 1 0 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C PF00034.21 CCF48287.1 - 0.038 15.1 0.2 0.15 13.2 0.1 2.1 2 1 0 2 2 2 0 Cytochrome c Ribosomal_60s PF00428.19 CCF48288.1 - 1.4e-26 92.9 11.1 1.9e-26 92.4 11.1 1.2 1 0 0 1 1 1 1 60s Acidic ribosomal protein PSII PF00421.19 CCF48289.1 - 0.15 10.7 0.6 0.26 9.9 0.2 1.5 1 1 0 2 2 2 0 Photosystem II protein Ribosomal_S19 PF00203.21 CCF48290.1 - 2e-30 104.5 0.2 2.7e-30 104.1 0.2 1.2 1 0 0 1 1 1 1 Ribosomal protein S19 Ribosomal_L5e PF17144.4 CCF48291.1 - 2.3e-78 261.8 0.8 3.4e-78 261.3 0.0 1.6 2 0 0 2 2 2 1 Ribosomal large subunit proteins 60S L5, and 50S L18 Ribosomal_L18_c PF14204.6 CCF48291.1 - 8.2e-33 113.2 1.6 8.2e-33 113.2 1.6 2.1 2 1 1 3 3 3 1 Ribosomal L18 C-terminal region DUF5388 PF17363.2 CCF48291.1 - 0.062 13.5 0.0 0.5 10.6 0.0 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5388) Ribosomal_L15e PF00827.17 CCF48292.1 - 7.3e-89 296.6 12.1 8.3e-89 296.4 12.1 1.0 1 0 0 1 1 1 1 Ribosomal L15 UBA_6 PF18039.1 CCF48292.1 - 0.12 12.3 0.0 0.21 11.6 0.0 1.3 1 0 0 1 1 1 0 UBA-like domain TPP1 PF10341.9 CCF48293.1 - 4.4e-05 23.4 0.0 0.00013 21.9 0.0 1.8 1 0 0 1 1 1 1 Shelterin complex subunit, TPP1/ACD NESP55 PF06390.12 CCF48293.1 - 0.099 12.2 10.3 0.65 9.5 2.9 2.2 2 0 0 2 2 2 0 Neuroendocrine-specific golgi protein P55 (NESP55) Trypan_PARP PF05887.11 CCF48293.1 - 0.26 11.3 9.1 0.52 10.3 8.0 2.0 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) Keratin_2_head PF16208.5 CCF48293.1 - 0.28 11.3 16.3 0.15 12.2 11.5 2.3 2 0 0 2 2 2 0 Keratin type II head Rhomboid PF01694.22 CCF48294.1 - 0.0021 18.1 2.1 0.0021 18.1 2.1 1.7 2 0 0 2 2 2 1 Rhomboid family DER1 PF04511.15 CCF48294.1 - 0.012 15.6 5.4 0.019 14.9 5.4 1.2 1 0 0 1 1 1 0 Der1-like family UBA PF00627.31 CCF48294.1 - 0.044 13.7 0.0 0.46 10.4 0.0 2.3 2 0 0 2 2 2 0 UBA/TS-N domain DUF1751 PF08551.10 CCF48294.1 - 1.2 9.8 4.7 0.58 10.8 1.0 2.2 1 1 1 2 2 2 0 Eukaryotic integral membrane protein (DUF1751) EAP30 PF04157.16 CCF48295.1 - 1.3e-66 224.3 0.4 1.6e-66 224.0 0.4 1.1 1 0 0 1 1 1 1 EAP30/Vps36 family HDV_ag PF01517.18 CCF48295.1 - 0.095 12.5 0.0 0.32 10.7 0.0 1.7 2 0 0 2 2 2 0 Hepatitis delta virus delta antigen TB2_DP1_HVA22 PF03134.19 CCF48296.1 - 1.7e-25 88.7 10.6 2.7e-25 88.1 10.6 1.3 1 0 0 1 1 1 1 TB2/DP1, HVA22 family DUF2304 PF10066.9 CCF48296.1 - 0.19 11.9 3.2 0.31 11.3 3.2 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2304) Zn_clus PF00172.18 CCF48297.1 - 9e-07 28.9 6.1 0.0012 18.9 0.9 2.4 2 0 0 2 2 2 2 Fungal Zn(2)-Cys(6) binuclear cluster domain rve PF00665.26 CCF48298.1 - 1.3e-06 28.6 0.0 2.3e-06 27.8 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain gag_pre-integrs PF13976.6 CCF48298.1 - 0.00039 20.2 0.2 0.0018 18.1 0.1 2.3 1 1 0 1 1 1 1 GAG-pre-integrase domain rve_3 PF13683.6 CCF48298.1 - 0.11 12.3 0.0 0.25 11.1 0.0 1.6 1 0 0 1 1 1 0 Integrase core domain Glyco_hydro_11 PF00457.17 CCF48300.1 - 3.5e-55 186.4 16.5 4.1e-55 186.1 16.5 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 11 Uroplakin_II PF07353.12 CCF48300.1 - 0.0022 17.5 0.5 0.0034 16.9 0.5 1.3 1 0 0 1 1 1 1 Uroplakin II Foie-gras_1 PF11817.8 CCF48301.1 - 2.3e-26 93.0 0.0 3e-25 89.3 0.0 2.4 2 1 0 2 2 2 1 Foie gras liver health family 1 Gryzun PF07919.12 CCF48301.1 - 6.6e-06 25.2 0.2 2e-05 23.6 0.0 1.8 2 0 0 2 2 2 1 Gryzun, putative trafficking through Golgi TPR_12 PF13424.6 CCF48301.1 - 2 8.7 4.0 1.1 9.6 0.7 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat PRCC PF10253.9 CCF48302.1 - 1.3e-20 75.2 5.0 1.3e-20 75.2 5.0 4.1 2 2 0 2 2 2 1 Mitotic checkpoint regulator, MAD2B-interacting TMEM190 PF15431.6 CCF48302.1 - 0.15 12.2 0.0 0.28 11.3 0.0 1.4 1 0 0 1 1 1 0 Transmembrane protein 190 Peptidase_S10 PF00450.22 CCF48303.1 - 1.1e-103 347.9 0.0 1.3e-103 347.6 0.0 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase Varsurf_PPLC PF03490.13 CCF48303.1 - 0.062 13.3 0.1 0.14 12.1 0.1 1.6 1 0 0 1 1 1 0 Variant-surface-glycoprotein phospholipase C YL1_C PF08265.11 CCF48306.1 - 6.3e-15 54.6 0.2 6.3e-15 54.6 0.2 1.6 2 0 0 2 2 2 1 YL1 nuclear protein C-terminal domain Bcl-2_BAD PF10514.9 CCF48306.1 - 0.085 13.3 3.9 0.085 13.3 2.9 1.5 1 1 1 2 2 2 0 Pro-apoptotic Bcl-2 protein, BAD MAJIN PF15077.6 CCF48306.1 - 1.3 8.8 9.3 1.4 8.6 9.3 1.1 1 0 0 1 1 1 0 Membrane-anchored junction protein TraV PF09676.10 CCF48306.1 - 3.5 8.6 8.0 14 6.6 8.0 1.9 1 1 0 1 1 1 0 Type IV conjugative transfer system lipoprotein (TraV) DUF4746 PF15928.5 CCF48306.1 - 7.7 5.8 11.5 5.9 6.2 10.2 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4746) DNA_pol3_gamma3 PF12169.8 CCF48308.1 - 0.099 12.6 0.0 0.15 12.0 0.0 1.2 1 0 0 1 1 1 0 DNA polymerase III subunits gamma and tau domain III Adeno_E3_CR2 PF02439.15 CCF48309.1 - 0.28 11.0 0.1 0.49 10.2 0.1 1.4 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Prefoldin_2 PF01920.20 CCF48310.1 - 3.5e-24 84.8 7.7 4.8e-24 84.3 7.7 1.2 1 0 0 1 1 1 1 Prefoldin subunit PI3K_P85_iSH2 PF16454.5 CCF48310.1 - 0.00093 18.8 5.1 0.0079 15.8 5.0 2.0 1 1 0 1 1 1 1 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain Nsp1_C PF05064.13 CCF48310.1 - 0.022 14.6 0.8 0.022 14.6 0.8 2.2 2 1 0 2 2 2 0 Nsp1-like C-terminal region DUF4795 PF16043.5 CCF48310.1 - 0.037 13.6 6.6 0.099 12.2 1.4 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4795) DUF1955 PF09205.10 CCF48310.1 - 0.078 12.7 0.4 0.1 12.4 0.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1955) PKcGMP_CC PF16808.5 CCF48310.1 - 0.08 12.8 1.3 0.08 12.8 1.3 2.6 4 1 0 4 4 4 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Spc24 PF08286.11 CCF48310.1 - 0.081 13.2 9.8 27 5.1 9.6 2.2 1 1 0 1 1 1 0 Spc24 subunit of Ndc80 KfrA_N PF11740.8 CCF48310.1 - 0.092 13.4 1.2 0.13 13.0 1.2 1.3 1 1 0 1 1 1 0 Plasmid replication region DNA-binding N-term Prefoldin PF02996.17 CCF48310.1 - 0.13 12.2 5.9 0.19 11.6 2.6 2.1 1 1 1 2 2 2 0 Prefoldin subunit LRS4 PF10422.9 CCF48310.1 - 0.13 11.8 3.0 0.16 11.5 3.0 1.2 1 0 0 1 1 1 0 Monopolin complex subunit LRS4 YabA PF06156.13 CCF48310.1 - 0.47 11.1 0.2 0.47 11.1 0.2 2.1 1 1 1 2 2 2 0 Initiation control protein YabA FapA PF03961.13 CCF48310.1 - 0.56 8.8 4.4 0.69 8.5 4.4 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A bZIP_1 PF00170.21 CCF48310.1 - 0.74 10.0 4.8 1.5 9.0 1.8 2.4 2 0 0 2 2 2 0 bZIP transcription factor CCDC-167 PF15188.6 CCF48310.1 - 0.77 10.1 8.1 1.8 9.0 8.1 1.6 1 1 0 1 1 1 0 Coiled-coil domain-containing protein 167 Seryl_tRNA_N PF02403.22 CCF48310.1 - 0.77 10.0 6.3 0.15 12.3 1.0 2.0 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Glyco_trans_4_4 PF13579.6 CCF48311.1 - 2.1e-09 38.0 2.9 3.6e-09 37.2 1.6 2.0 2 0 0 2 2 2 1 Glycosyl transferase 4-like domain Glyco_transf_4 PF13439.6 CCF48311.1 - 2.3e-06 27.7 0.1 1e-05 25.6 0.7 1.7 2 0 0 2 2 2 1 Glycosyltransferase Family 4 Glyco_trans_1_4 PF13692.6 CCF48311.1 - 0.00043 20.7 0.0 0.0009 19.7 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.6 CCF48311.1 - 0.0093 16.3 0.0 0.019 15.3 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glycos_transf_1 PF00534.20 CCF48311.1 - 0.1 12.1 0.0 0.2 11.2 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferases group 1 RT_RNaseH_2 PF17919.1 CCF48315.1 - 3.3e-27 94.5 0.0 7.3e-27 93.3 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 CCF48315.1 - 2.8e-18 66.1 0.0 6.2e-18 65.0 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 CCF48315.1 - 7.3e-16 58.4 0.0 2e-15 57.0 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 CCF48315.1 - 0.055 13.3 2.4 0.077 12.8 0.1 2.3 2 0 0 2 2 2 0 Integrase core domain Retrotrans_gag PF03732.17 CCF48316.1 - 0.0023 18.1 0.1 0.0054 17.0 0.1 1.7 2 0 0 2 2 2 1 Retrotransposon gag protein zf-CCHC PF00098.23 CCF48316.1 - 0.014 15.4 0.9 0.014 15.4 0.9 1.8 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_5 PF14787.6 CCF48316.1 - 0.021 14.5 3.1 0.042 13.6 3.1 1.5 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger eIF3g PF12353.8 CCF48316.1 - 0.041 14.3 0.2 0.082 13.3 0.2 1.4 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit G zf-CCHC_2 PF13696.6 CCF48316.1 - 0.7 9.8 3.0 2.1 8.2 3.0 1.9 1 0 0 1 1 1 0 Zinc knuckle DUF1992 PF09350.10 CCF48317.1 - 1.9e-18 66.4 3.6 2.1e-18 66.2 0.2 2.8 4 0 0 4 4 4 1 Domain of unknown function (DUF1992) Dynein_light PF01221.18 CCF48318.1 - 4.1e-36 123.2 0.3 4.7e-36 123.0 0.3 1.0 1 0 0 1 1 1 1 Dynein light chain type 1 Suc_Fer-like PF06999.12 CCF48320.1 - 1.1e-23 84.1 0.0 2e-23 83.3 0.0 1.4 1 0 0 1 1 1 1 Sucrase/ferredoxin-like LIAS_N PF16881.5 CCF48320.1 - 1.4e-20 73.8 0.0 3.3e-20 72.5 0.0 1.7 1 0 0 1 1 1 1 N-terminal domain of lipoyl synthase of Radical_SAM family Radical_SAM PF04055.21 CCF48320.1 - 2.4e-10 41.0 0.0 4.3e-10 40.2 0.0 1.4 1 0 0 1 1 1 1 Radical SAM superfamily LRR_9 PF14580.6 CCF48322.1 - 1.2e-56 190.9 0.5 1.7e-56 190.5 0.5 1.1 1 0 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.7 CCF48322.1 - 6.8e-11 42.2 9.6 3e-07 30.6 7.1 3.3 1 1 4 5 5 5 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 CCF48322.1 - 8.1e-09 35.1 9.8 1e-08 34.8 6.7 2.5 3 0 0 3 3 3 1 Leucine rich repeat LRR_1 PF00560.33 CCF48322.1 - 2.6 8.9 11.1 20 6.3 0.9 4.6 4 2 0 4 4 4 0 Leucine Rich Repeat LRR_6 PF13516.6 CCF48322.1 - 4.2 7.7 11.9 15 6.0 0.0 4.6 6 0 0 6 6 6 0 Leucine Rich repeat MFS_1 PF07690.16 CCF48323.1 - 3.9e-18 65.5 41.6 3.9e-18 65.5 41.6 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily Hexapep_loop PF18776.1 CCF48323.1 - 0.12 12.0 0.5 0.26 10.9 0.5 1.5 1 0 0 1 1 1 0 Hexapeptide repeat including loop OATP PF03137.20 CCF48323.1 - 1.9 6.6 20.6 0.0073 14.6 8.0 2.8 1 1 2 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family CRAL_TRIO_2 PF13716.6 CCF48324.1 - 9.1e-32 110.1 0.0 1.6e-31 109.3 0.0 1.3 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain RhoGAP PF00620.27 CCF48324.1 - 3.6e-23 82.1 0.0 6.5e-23 81.2 0.0 1.4 1 0 0 1 1 1 1 RhoGAP domain AAA PF00004.29 CCF48325.1 - 1.6e-49 167.7 0.0 3.3e-41 140.8 0.0 2.9 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 CCF48325.1 - 1.3e-08 34.5 0.0 4.8e-08 32.7 0.0 2.0 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 CCF48325.1 - 9.5e-06 26.1 6.1 7.7e-05 23.1 0.0 4.3 4 1 0 4 4 4 1 AAA ATPase domain IstB_IS21 PF01695.17 CCF48325.1 - 3.9e-05 23.5 0.0 8.5e-05 22.4 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_2 PF07724.14 CCF48325.1 - 9.1e-05 22.6 0.9 0.00031 20.9 0.0 2.4 2 0 0 2 2 1 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 CCF48325.1 - 0.0012 18.8 0.0 0.014 15.4 0.0 2.9 3 1 0 3 3 3 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 CCF48325.1 - 0.0084 16.4 0.2 0.36 11.1 0.0 3.4 3 1 0 4 4 3 1 AAA domain AAA_18 PF13238.6 CCF48325.1 - 0.027 15.0 2.4 0.065 13.8 0.0 3.1 3 0 0 3 3 1 0 AAA domain AAA_33 PF13671.6 CCF48325.1 - 0.09 12.9 0.0 0.09 12.9 0.0 4.1 4 0 0 4 4 3 0 AAA domain Sigma54_activ_2 PF14532.6 CCF48325.1 - 0.092 12.9 0.0 0.74 9.9 0.0 2.3 2 0 0 2 2 2 0 Sigma-54 interaction domain TIP49 PF06068.13 CCF48325.1 - 0.1 11.8 0.0 0.19 10.9 0.0 1.3 1 0 0 1 1 1 0 TIP49 P-loop domain RNA_helicase PF00910.22 CCF48325.1 - 0.1 13.0 0.0 0.35 11.3 0.0 1.9 1 0 0 1 1 1 0 RNA helicase Bromodomain PF00439.25 CCF48325.1 - 0.11 12.6 0.1 0.29 11.2 0.1 1.7 1 0 0 1 1 1 0 Bromodomain AAA_7 PF12775.7 CCF48325.1 - 0.11 12.0 0.0 0.55 9.7 0.0 2.0 2 0 0 2 2 2 0 P-loop containing dynein motor region Herpes_LMP2 PF07415.11 CCF48325.1 - 0.51 9.1 4.9 1.2 7.8 4.9 1.6 1 0 0 1 1 1 0 Gammaherpesvirus latent membrane protein (LMP2) protein ABC_tran PF00005.27 CCF48325.1 - 1.1 9.8 0.0 1.1 9.8 0.0 3.4 3 1 1 4 4 2 0 ABC transporter WD40 PF00400.32 CCF48326.1 - 2e-43 145.5 19.3 9.5e-10 38.9 0.9 8.3 8 0 0 8 8 8 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF48326.1 - 8.4e-18 64.5 0.2 9.8e-05 22.6 0.0 6.5 4 3 2 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CCF48326.1 - 1.2e-05 24.5 0.3 0.26 10.2 0.0 3.9 4 1 2 6 6 6 2 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 CCF48326.1 - 0.11 12.4 0.0 8.5 6.2 0.0 2.5 2 0 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A FGGY_N PF00370.21 CCF48328.1 - 2.9e-72 243.2 0.7 4e-72 242.7 0.7 1.2 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain FGGY_C PF02782.16 CCF48328.1 - 4.5e-66 222.4 1.5 2.6e-65 219.9 0.7 2.1 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain TFIIS_C PF01096.18 CCF48329.1 - 3.1e-19 68.5 3.6 3.1e-19 68.5 3.6 2.7 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) RNA_POL_M_15KD PF02150.16 CCF48329.1 - 2.7e-10 39.9 1.8 2.7e-10 39.9 1.8 2.6 3 0 0 3 3 3 1 RNA polymerases M/15 Kd subunit Zn_Tnp_IS1595 PF12760.7 CCF48329.1 - 0.02 14.9 8.2 0.093 12.7 0.4 2.3 2 0 0 2 2 2 0 Transposase zinc-ribbon domain PH_17 PF18012.1 CCF48329.1 - 0.042 13.6 0.0 0.069 12.9 0.0 1.4 1 0 0 1 1 1 0 PH domain Lar_restr_allev PF14354.6 CCF48329.1 - 0.48 10.8 7.5 2.1 8.8 1.0 2.2 2 0 0 2 2 2 0 Restriction alleviation protein Lar Auto_anti-p27 PF06677.12 CCF48329.1 - 0.61 10.3 6.0 5 7.4 2.5 2.4 2 0 0 2 2 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) DUF1936 PF09151.10 CCF48329.1 - 2.6 8.0 0.1 2.6 8.0 0.1 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF1936) TANGO2 PF05742.12 CCF48330.1 - 1.7e-53 182.3 0.0 3.3e-53 181.3 0.0 1.5 1 1 0 1 1 1 1 Transport and Golgi organisation 2 Ribosomal_S19e PF01090.19 CCF48331.1 - 2.5e-56 189.2 0.0 2.9e-56 189.0 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S19e Astro_capsid_p PF12226.8 CCF48331.1 - 0.046 12.9 0.3 0.04 13.1 0.3 1.2 1 0 0 1 1 1 0 Turkey astrovirus capsid protein SDA1 PF05285.12 CCF48331.1 - 0.057 12.8 8.3 0.067 12.6 8.3 1.1 1 0 0 1 1 1 0 SDA1 RNA_pol_3_Rpc31 PF11705.8 CCF48331.1 - 0.071 13.4 9.1 0.079 13.2 9.1 1.1 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 NOA36 PF06524.12 CCF48331.1 - 0.51 9.6 11.0 0.61 9.4 11.0 1.1 1 0 0 1 1 1 0 NOA36 protein CDC45 PF02724.14 CCF48331.1 - 0.75 8.0 6.3 0.77 8.0 6.3 1.1 1 0 0 1 1 1 0 CDC45-like protein Ribosomal_60s PF00428.19 CCF48331.1 - 0.94 10.1 10.2 1.7 9.3 10.2 1.4 1 0 0 1 1 1 0 60s Acidic ribosomal protein AphA_like PF14557.6 CCF48332.1 - 0.026 14.3 0.7 0.063 13.0 0.7 1.7 1 0 0 1 1 1 0 Putative AphA-like transcriptional regulator HA2 PF04408.23 CCF48333.1 - 6.9e-23 81.0 0.0 6.9e-23 81.0 0.0 4.1 4 1 0 4 4 4 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 CCF48333.1 - 5.5e-12 45.9 0.0 1.9e-11 44.1 0.0 2.0 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 CCF48333.1 - 2e-11 44.2 1.1 1.3e-09 38.3 0.0 3.3 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DEAD PF00270.29 CCF48333.1 - 4e-06 26.7 0.2 8.8e-06 25.6 0.2 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 CCF48333.1 - 7e-05 23.1 0.1 0.00045 20.5 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 CCF48333.1 - 0.0013 19.1 0.3 0.013 15.9 0.1 2.3 2 0 0 2 2 2 1 AAA domain ATPase PF06745.13 CCF48333.1 - 0.0018 17.7 0.0 0.0061 15.9 0.0 1.8 2 0 0 2 2 2 1 KaiC FtsK_SpoIIIE PF01580.18 CCF48333.1 - 0.064 12.6 0.0 0.17 11.2 0.0 1.7 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_23 PF13476.6 CCF48333.1 - 0.091 13.2 0.0 0.091 13.2 0.0 4.4 5 1 0 5 5 5 0 AAA domain 4HBT PF03061.22 CCF48334.1 - 3.9e-11 43.2 0.1 7.8e-11 42.2 0.1 1.4 1 0 0 1 1 1 1 Thioesterase superfamily DUF4442 PF14539.6 CCF48334.1 - 0.064 13.4 0.0 0.092 12.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4442) DHDPS PF00701.22 CCF48335.1 - 2.4e-36 124.9 0.0 2.8e-36 124.7 0.0 1.0 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family ParA PF10609.9 CCF48336.1 - 6.4e-73 245.2 4.5 1.4e-39 136.0 0.0 2.9 2 1 0 2 2 2 2 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 CCF48336.1 - 1.9e-10 40.9 0.0 6.8e-10 39.1 0.0 2.0 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 CCF48336.1 - 5.5e-08 32.9 0.1 0.00011 22.2 0.0 2.1 2 0 0 2 2 2 2 AAA domain AAA_26 PF13500.6 CCF48336.1 - 4.4e-06 26.7 0.1 0.0008 19.3 0.0 2.1 2 0 0 2 2 2 2 AAA domain ArsA_ATPase PF02374.15 CCF48336.1 - 0.00013 21.3 2.8 0.00051 19.3 0.5 2.3 2 1 1 3 3 3 1 Anion-transporting ATPase Fer4_NifH PF00142.18 CCF48336.1 - 0.0041 16.6 0.1 0.055 12.9 0.1 2.1 2 0 0 2 2 2 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family MipZ PF09140.11 CCF48336.1 - 0.0063 15.8 0.1 0.015 14.6 0.0 1.6 2 0 0 2 2 2 1 ATPase MipZ AAA_25 PF13481.6 CCF48336.1 - 0.015 14.9 0.1 0.038 13.5 0.0 1.7 2 0 0 2 2 2 0 AAA domain CBP_BcsQ PF06564.12 CCF48336.1 - 0.037 13.5 0.1 1.7 8.0 0.1 2.1 2 0 0 2 2 2 0 Cellulose biosynthesis protein BcsQ DNA_ligase_A_M PF01068.21 CCF48337.1 - 3e-35 121.7 0.0 3.8e-23 82.2 0.0 4.4 4 0 0 4 4 4 4 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 CCF48337.1 - 1.7e-34 119.7 0.0 1.3e-32 113.5 0.0 2.7 3 0 0 3 3 3 1 DNA ligase N terminus DNA_ligase_A_C PF04679.15 CCF48337.1 - 5.3e-16 59.0 0.0 1.3e-15 57.8 0.0 1.7 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region RTP1_C2 PF10304.9 CCF48337.1 - 0.12 12.0 0.4 2 8.2 0.0 2.3 2 0 0 2 2 2 0 Required for nuclear transport of RNA pol II C-terminus 2 Pkinase PF00069.25 CCF48338.1 - 2.2e-36 125.6 0.0 3.8e-36 124.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF48338.1 - 3.9e-12 46.0 0.0 6.1e-12 45.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinetochor_Ybp2 PF08568.10 CCF48338.1 - 9e-08 31.1 0.1 4.1e-06 25.6 0.1 2.2 2 0 0 2 2 2 1 Uncharacterised protein family, YAP/Alf4/glomulin APH PF01636.23 CCF48338.1 - 1.7e-05 24.9 0.0 1.7e-05 24.9 0.0 2.4 2 0 0 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 CCF48338.1 - 0.0045 16.6 0.0 0.0087 15.7 0.0 1.4 1 0 0 1 1 1 1 Choline/ethanolamine kinase Kdo PF06293.14 CCF48338.1 - 0.057 12.8 0.0 0.15 11.4 0.0 1.6 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 CCF48338.1 - 0.32 9.7 0.9 1.2 7.9 0.9 2.0 1 1 0 1 1 1 0 Fungal protein kinase Esterase_phd PF10503.9 CCF48339.1 - 3.4e-13 49.6 0.4 1.1e-12 47.9 0.4 1.7 1 1 0 1 1 1 1 Esterase PHB depolymerase Peptidase_S9 PF00326.21 CCF48339.1 - 4e-09 36.3 0.7 6e-09 35.7 0.7 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_1 PF00561.20 CCF48339.1 - 0.003 17.3 1.2 0.0059 16.3 1.0 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CCF48339.1 - 0.0035 16.6 0.0 0.047 13.0 0.1 2.0 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 CCF48339.1 - 0.021 15.4 0.9 0.024 15.3 0.2 1.6 1 1 0 1 1 1 0 Alpha/beta hydrolase family DUF915 PF06028.11 CCF48339.1 - 0.19 11.0 0.2 0.32 10.3 0.2 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF915) Hydrolase_6 PF13344.6 CCF48341.1 - 1.6e-22 79.5 0.0 3.1e-22 78.6 0.0 1.5 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 CCF48341.1 - 1.6e-20 72.9 0.0 3.4e-20 71.9 0.0 1.6 1 0 0 1 1 1 1 HAD-hyrolase-like HAD_2 PF13419.6 CCF48341.1 - 0.02 15.0 0.0 0.71 9.9 0.0 2.5 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase DUF829 PF05705.14 CCF48342.1 - 1.2e-22 81.0 3.4 5.5e-17 62.5 0.0 3.7 4 1 0 4 4 4 2 Eukaryotic protein of unknown function (DUF829) Transglut_core3 PF13471.6 CCF48342.1 - 0.0097 15.8 0.1 0.053 13.4 0.1 2.3 1 0 0 1 1 1 1 Transglutaminase-like superfamily MFS_1 PF07690.16 CCF48343.1 - 1.1e-22 80.5 48.7 1.1e-22 80.5 48.7 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily RRM_1 PF00076.22 CCF48344.1 - 3e-32 110.2 0.0 4.3e-17 61.7 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 CCF48344.1 - 0.0014 18.6 0.1 0.27 11.3 0.0 2.3 2 0 0 2 2 2 2 Limkain b1 PHM7_cyt PF14703.6 CCF48344.1 - 0.0055 17.0 2.9 0.32 11.2 0.0 2.9 3 0 0 3 3 3 2 Cytosolic domain of 10TM putative phosphate transporter RRM_7 PF16367.5 CCF48344.1 - 0.0083 16.2 0.0 0.074 13.2 0.0 2.3 2 0 0 2 2 2 1 RNA recognition motif RRM_5 PF13893.6 CCF48344.1 - 0.0098 15.5 0.0 0.18 11.4 0.0 2.2 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) OB_RNB PF08206.11 CCF48344.1 - 0.012 15.3 0.2 0.28 10.9 0.1 2.3 2 0 0 2 2 2 0 Ribonuclease B OB domain Rab5ip PF07019.12 CCF48345.1 - 3.2e-16 59.7 5.0 7.6e-16 58.5 5.0 1.6 1 1 0 1 1 1 1 Rab5-interacting protein (Rab5ip) Shugoshin_C PF07557.11 CCF48346.1 - 3.1e-07 30.1 3.4 3.1e-07 30.1 3.4 3.5 3 0 0 3 3 3 1 Shugoshin C terminus Shugoshin_N PF07558.11 CCF48346.1 - 4.1e-06 26.6 1.6 8.6e-06 25.5 1.6 1.6 1 0 0 1 1 1 1 Shugoshin N-terminal coiled-coil region Actin PF00022.19 CCF48347.1 - 1.9e-34 119.0 0.0 1.5e-27 96.2 0.0 2.5 2 1 0 2 2 2 2 Actin MMS19_N PF14500.6 CCF48347.1 - 0.063 12.8 0.1 0.12 11.9 0.1 1.4 1 0 0 1 1 1 0 Dos2-interacting transcription regulator of RNA-Pol-II Band_7 PF01145.25 CCF48348.1 - 9.5e-22 77.9 0.3 9.5e-22 77.9 0.3 1.6 2 0 0 2 2 2 1 SPFH domain / Band 7 family Ribosomal_L1 PF00687.21 CCF48349.1 - 8.7e-48 162.8 2.8 1e-47 162.5 2.8 1.0 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family DNA_pol_lambd_f PF10391.9 CCF48349.1 - 0.065 13.1 0.1 7.5 6.5 0.0 2.5 2 0 0 2 2 2 0 Fingers domain of DNA polymerase lambda CN_hydrolase PF00795.22 CCF48350.1 - 4.6e-47 160.6 0.0 1.3e-46 159.1 0.0 1.6 1 1 0 1 1 1 1 Carbon-nitrogen hydrolase MFS_1 PF07690.16 CCF48351.1 - 1.1e-39 136.4 46.8 1.1e-27 97.0 20.7 2.3 2 0 0 2 2 2 2 Major Facilitator Superfamily MFS_1 PF07690.16 CCF48352.1 - 1.5e-18 66.9 26.3 1.5e-18 66.9 26.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily AA_permease PF00324.21 CCF48353.1 - 6.6e-115 384.4 45.0 7.9e-115 384.2 45.0 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 CCF48353.1 - 5.1e-30 104.6 49.0 6.4e-30 104.3 49.0 1.1 1 0 0 1 1 1 1 Amino acid permease DEAD PF00270.29 CCF48354.1 - 6.6e-19 68.3 0.0 4.6e-18 65.6 0.0 2.2 1 1 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CCF48354.1 - 8.4e-14 51.9 0.0 2.1e-11 44.1 0.0 2.5 2 0 0 2 2 2 2 Helicase conserved C-terminal domain RecQ_Zn_bind PF16124.5 CCF48354.1 - 2.6e-11 44.1 1.0 6.8e-11 42.7 1.0 1.8 1 0 0 1 1 1 1 RecQ zinc-binding ResIII PF04851.15 CCF48354.1 - 2.8e-05 24.2 0.0 8.3e-05 22.6 0.0 1.7 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit SecA_DEAD PF07517.14 CCF48354.1 - 0.015 14.6 0.0 0.023 14.0 0.0 1.2 1 0 0 1 1 1 0 SecA DEAD-like domain AMP-binding PF00501.28 CCF48355.1 - 0 1262.6 0.1 1.4e-72 244.7 0.0 6.3 6 0 0 6 6 6 6 AMP-binding enzyme Condensation PF00668.20 CCF48355.1 - 3.4e-138 461.2 0.0 3e-36 125.1 0.0 5.2 5 0 0 5 5 5 5 Condensation domain PP-binding PF00550.25 CCF48355.1 - 3.2e-69 229.2 8.6 5.6e-16 58.7 0.0 7.1 6 0 0 6 6 6 6 Phosphopantetheine attachment site AMP-binding_C PF13193.6 CCF48355.1 - 2.4e-23 82.9 0.9 0.00058 20.8 0.1 7.0 7 0 0 7 7 7 4 AMP-binding enzyme C-terminal domain Nitroreductase PF00881.24 CCF48355.1 - 0.076 13.1 0.0 18 5.3 0.0 3.4 3 0 0 3 3 3 0 Nitroreductase family AMP-binding PF00501.28 CCF48356.1 - 5.6e-73 245.9 0.0 7.7e-73 245.5 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme Condensation PF00668.20 CCF48356.1 - 4e-16 58.7 0.0 1.2e-15 57.2 0.0 1.7 2 0 0 2 2 2 1 Condensation domain PP-binding PF00550.25 CCF48356.1 - 4.6e-09 36.5 0.0 1.9e-08 34.5 0.0 2.1 1 0 0 1 1 1 1 Phosphopantetheine attachment site AMP-binding_C PF13193.6 CCF48356.1 - 1.9e-05 25.6 0.0 5.7e-05 24.0 0.0 1.9 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Neurensin PF14927.6 CCF48357.1 - 0.084 12.6 0.0 0.44 10.2 0.0 2.0 2 0 0 2 2 2 0 Neurensin Bac_export_2 PF01312.19 CCF48357.1 - 0.12 11.5 0.3 0.16 11.1 0.3 1.3 1 0 0 1 1 1 0 FlhB HrpN YscU SpaS Family DUF3112 PF11309.8 CCF48357.1 - 0.14 11.6 1.1 4.6 6.6 0.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3112) Thioesterase PF00975.20 CCF48360.1 - 1.9e-07 31.5 0.9 3.5e-05 24.0 0.3 2.4 2 1 0 2 2 2 2 Thioesterase domain Abhydrolase_6 PF12697.7 CCF48360.1 - 0.00086 20.0 0.0 0.00096 19.8 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family FMO-like PF00743.19 CCF48361.1 - 3.1e-12 45.7 0.0 3.1e-11 42.4 0.0 2.2 2 0 0 2 2 2 1 Flavin-binding monooxygenase-like NAD_binding_8 PF13450.6 CCF48361.1 - 1.2e-11 44.7 0.0 5.6e-11 42.5 0.0 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 CCF48361.1 - 2.1e-10 40.8 0.0 0.00033 20.7 0.0 3.3 3 0 0 3 3 3 3 FAD-NAD(P)-binding K_oxygenase PF13434.6 CCF48361.1 - 3.2e-10 39.7 0.0 2.7e-06 26.8 0.0 3.1 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.14 CCF48361.1 - 1.1e-06 28.1 0.0 0.00065 19.0 0.0 2.6 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CCF48361.1 - 1.8e-06 27.5 0.0 0.0079 15.5 0.0 3.5 2 1 1 3 3 3 3 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CCF48361.1 - 0.00013 21.7 0.1 0.0048 16.5 0.1 2.6 3 0 0 3 3 3 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 CCF48361.1 - 0.0027 18.2 0.0 0.013 16.1 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 CCF48361.1 - 0.0045 16.3 0.0 0.05 12.9 0.0 2.2 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase zn-ribbon_14 PF16503.5 CCF48361.1 - 0.018 14.5 0.3 0.12 11.9 0.2 2.2 2 0 0 2 2 2 0 Zinc-ribbon HI0933_like PF03486.14 CCF48361.1 - 0.25 10.0 0.2 0.94 8.1 0.1 1.8 2 0 0 2 2 2 0 HI0933-like protein FSH1 PF03959.13 CCF48362.1 - 4.6e-18 65.6 0.0 3.4e-14 53.0 0.0 2.1 2 0 0 2 2 2 2 Serine hydrolase (FSH1) Abhydrolase_2 PF02230.16 CCF48362.1 - 0.0092 15.8 0.3 0.11 12.3 0.3 2.2 1 1 0 1 1 1 1 Phospholipase/Carboxylesterase p450 PF00067.22 CCF48363.1 - 8.9e-64 215.9 0.0 1.4e-63 215.2 0.0 1.3 1 1 0 1 1 1 1 Cytochrome P450 Erf4 PF10256.9 CCF48364.1 - 4.1e-17 62.3 0.0 7.8e-16 58.2 0.0 2.5 2 0 0 2 2 2 1 Golgin subfamily A member 7/ERF4 family Pyridoxal_deC PF00282.19 CCF48365.1 - 2.2e-60 204.3 0.0 1.2e-57 195.3 0.0 2.0 1 1 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Beta_elim_lyase PF01212.21 CCF48365.1 - 3.6e-06 26.5 0.0 2e-05 24.0 0.0 2.0 2 0 0 2 2 2 1 Beta-eliminating lyase Aminotran_5 PF00266.19 CCF48365.1 - 0.0026 16.8 0.0 0.0039 16.2 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V DUF4799 PF16056.5 CCF48366.1 - 0.13 11.4 0.4 0.23 10.6 0.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4799) Aa_trans PF01490.18 CCF48367.1 - 1.7e-05 23.7 6.3 0.013 14.2 6.6 2.3 2 0 0 2 2 2 2 Transmembrane amino acid transporter protein zf-RING_2 PF13639.6 CCF48368.1 - 2.9e-08 33.9 13.4 5.6e-07 29.8 2.9 3.7 3 1 0 3 3 3 2 Ring finger domain zf-rbx1 PF12678.7 CCF48368.1 - 0.00024 21.3 12.5 0.00047 20.4 3.4 3.0 3 0 0 3 3 3 2 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 CCF48368.1 - 0.00079 19.4 5.5 0.063 13.3 1.7 2.9 2 0 0 2 2 2 2 RING-type zinc-finger zf-RING_5 PF14634.6 CCF48368.1 - 0.00099 19.0 11.1 0.0042 17.0 0.6 3.2 2 1 0 2 2 2 1 zinc-RING finger domain zf-ANAPC11 PF12861.7 CCF48368.1 - 0.0011 18.9 0.5 0.0011 18.9 0.5 2.8 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4 PF00097.25 CCF48368.1 - 0.0021 17.9 11.9 0.0085 16.0 1.1 3.0 3 0 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 CCF48368.1 - 0.014 15.2 0.4 0.014 15.2 0.4 3.1 4 0 0 4 4 4 0 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 CCF48368.1 - 0.055 13.2 3.4 5.2 6.9 0.1 3.3 3 0 0 3 3 3 0 RING-like zinc finger zf-4CXXC_R1 PF10497.9 CCF48368.1 - 0.13 12.5 5.9 3.7 7.8 0.5 2.9 3 0 0 3 3 3 0 Zinc-finger domain of monoamine-oxidase A repressor R1 zf-C3HC4_2 PF13923.6 CCF48368.1 - 1.3 8.9 18.5 0.32 10.9 0.5 3.8 4 0 0 4 4 4 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 CCF48368.1 - 2.9 7.8 13.6 0.46 10.4 2.2 3.5 3 1 0 3 3 3 0 Prokaryotic RING finger family 4 RINGv PF12906.7 CCF48368.1 - 2.9 8.1 8.6 0.21 11.7 2.7 2.2 2 0 0 2 2 2 0 RING-variant domain Zn_ribbon_17 PF17120.5 CCF48368.1 - 8.6 6.1 9.8 1.2 8.8 1.4 2.9 3 0 0 3 3 3 0 Zinc-ribbon, C4HC2 type zf-RING_4 PF14570.6 CCF48368.1 - 9.3 6.1 8.7 8.9 6.2 0.4 3.1 3 0 0 3 3 3 0 RING/Ubox like zinc-binding domain GILT PF03227.16 CCF48370.1 - 2.4e-13 50.3 0.5 4.7e-13 49.3 0.5 1.5 1 0 0 1 1 1 1 Gamma interferon inducible lysosomal thiol reductase (GILT) PglZ PF08665.12 CCF48370.1 - 0.14 12.2 0.2 0.28 11.3 0.2 1.4 1 0 0 1 1 1 0 PglZ domain 4HBT PF03061.22 CCF48371.1 - 6.8e-06 26.4 0.1 0.028 14.7 0.0 2.5 2 0 0 2 2 2 2 Thioesterase superfamily Pkinase PF00069.25 CCF48372.1 - 1.6e-56 191.6 0.0 2.9e-56 190.7 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain DUF3543 PF12063.8 CCF48372.1 - 2.1e-51 174.7 0.0 5.2e-51 173.4 0.0 1.7 1 1 0 1 1 1 1 Domain of unknown function (DUF3543) Pkinase_Tyr PF07714.17 CCF48372.1 - 4.4e-41 140.9 0.0 2.7e-40 138.3 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CCF48372.1 - 0.038 12.8 0.1 0.092 11.5 0.0 1.6 2 0 0 2 2 2 0 Fungal protein kinase WD40 PF00400.32 CCF48374.1 - 3.8e-27 94.0 20.2 9.9e-07 29.4 0.2 7.5 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF48374.1 - 9.2e-13 48.3 0.2 2.9e-05 24.3 0.0 4.7 2 1 3 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CCF48374.1 - 0.0001 21.4 0.6 0.88 8.5 0.0 4.1 1 1 4 5 5 5 2 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 CCF48374.1 - 0.0019 17.6 0.0 0.007 15.7 0.0 1.9 3 0 0 3 3 3 1 WD40-like domain Frtz PF11768.8 CCF48374.1 - 0.023 13.0 0.0 0.069 11.5 0.0 1.7 2 0 0 2 2 2 0 WD repeat-containing and planar cell polarity effector protein Fritz PQQ_3 PF13570.6 CCF48374.1 - 0.15 12.6 11.8 4.6 7.9 0.0 5.0 5 0 0 5 5 5 0 PQQ-like domain IKI3 PF04762.12 CCF48374.1 - 0.19 9.7 0.1 0.34 8.8 0.1 1.5 1 1 0 1 1 1 0 IKI3 family Lin-8 PF03353.15 CCF48374.1 - 4.8 6.6 9.4 7 6.1 9.4 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Roughex PF06020.11 CCF48374.1 - 9.6 5.2 10.4 14 4.7 10.4 1.1 1 0 0 1 1 1 0 Drosophila roughex protein MutS_V PF00488.21 CCF48375.1 - 1.3e-48 165.5 0.0 2.2e-48 164.8 0.0 1.3 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 CCF48375.1 - 2.7e-09 37.5 3.4 2.7e-09 37.5 3.4 2.5 2 0 0 2 2 2 1 MutS domain III MutS_IV PF05190.18 CCF48375.1 - 1.5e-06 28.4 0.1 3.1e-06 27.4 0.1 1.6 1 0 0 1 1 1 1 MutS family domain IV MutS_II PF05188.17 CCF48375.1 - 1.3e-05 25.5 0.2 4.3e-05 23.8 0.0 2.0 2 0 0 2 2 2 1 MutS domain II AAA_29 PF13555.6 CCF48375.1 - 0.016 14.9 0.0 0.041 13.6 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_23 PF13476.6 CCF48375.1 - 0.061 13.8 0.0 0.42 11.1 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_21 PF13304.6 CCF48375.1 - 0.062 13.1 0.0 15 5.2 0.0 2.5 1 1 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system MIF4G_like_2 PF09090.11 CCF48375.1 - 0.23 10.9 1.8 3.2 7.1 0.1 2.4 2 0 0 2 2 2 0 MIF4G like Ribosomal_L7Ae PF01248.26 CCF48376.1 - 1.2e-27 95.4 0.1 1.6e-27 95.1 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family PELOTA_1 PF15608.6 CCF48376.1 - 0.0021 17.9 0.0 0.0028 17.5 0.0 1.2 1 0 0 1 1 1 1 PELOTA RNA binding domain RNase_P_pop3 PF08228.11 CCF48376.1 - 0.0073 16.4 0.0 0.0086 16.1 0.0 1.1 1 0 0 1 1 1 1 RNase P subunit Pop3 DUF908 PF06012.12 CCF48377.1 - 0.43 9.9 4.5 0.64 9.4 4.5 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) Arrestin_N PF00339.29 CCF48378.1 - 0.2 11.7 0.0 0.46 10.5 0.0 1.5 1 0 0 1 1 1 0 Arrestin (or S-antigen), N-terminal domain UPF0203 PF05254.12 CCF48379.1 - 2.7e-18 66.0 2.0 2.2e-17 63.1 2.0 2.1 1 1 0 1 1 1 1 Uncharacterised protein family (UPF0203) UCR_hinge PF02320.16 CCF48379.1 - 0.057 13.6 0.2 3.4 8.0 0.0 2.3 2 0 0 2 2 2 0 Ubiquinol-cytochrome C reductase hinge protein 3Beta_HSD PF01073.19 CCF48380.1 - 1.7e-16 60.1 0.0 2.7e-16 59.4 0.0 1.4 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 CCF48380.1 - 1.4e-15 57.5 0.0 3.4e-15 56.2 0.0 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 CCF48380.1 - 6.5e-14 51.7 0.0 2e-12 46.9 0.0 2.1 1 1 0 1 1 1 1 Male sterility protein NAD_binding_10 PF13460.6 CCF48380.1 - 9.4e-11 41.9 0.0 1.6e-10 41.2 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 CCF48380.1 - 3e-09 36.8 0.0 4.8e-09 36.1 0.0 1.3 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NmrA PF05368.13 CCF48380.1 - 1e-06 28.5 0.0 1.7e-06 27.7 0.0 1.4 1 0 0 1 1 1 1 NmrA-like family adh_short PF00106.25 CCF48380.1 - 0.00018 21.1 0.0 0.001 18.5 0.0 2.0 2 0 0 2 2 2 1 short chain dehydrogenase Polysacc_synt_2 PF02719.15 CCF48380.1 - 0.0012 18.1 0.0 0.002 17.3 0.0 1.4 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein KR PF08659.10 CCF48380.1 - 0.01 15.8 0.1 0.06 13.3 0.1 2.0 1 1 0 1 1 1 0 KR domain Ldh_1_N PF00056.23 CCF48380.1 - 0.02 15.0 0.0 0.048 13.7 0.0 1.6 1 1 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain Sacchrp_dh_NADP PF03435.18 CCF48380.1 - 0.058 13.7 0.0 0.13 12.5 0.0 1.6 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain Ribonuc_red_sm PF00268.21 CCF48381.1 - 9.7e-117 389.4 1.4 1.2e-116 389.1 1.4 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, small chain Hydrolase_4 PF12146.8 CCF48382.1 - 1.8e-07 30.7 0.2 2.8e-06 26.8 0.2 2.1 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 CCF48382.1 - 8.8e-06 25.5 0.0 1.3e-05 25.0 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CCF48382.1 - 8.5e-05 23.3 0.0 0.00012 22.8 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Lipase_3 PF01764.25 CCF48382.1 - 0.0041 17.0 0.0 0.0075 16.1 0.0 1.5 1 1 0 1 1 1 1 Lipase (class 3) DUF900 PF05990.12 CCF48382.1 - 0.033 13.7 0.0 0.1 12.1 0.0 1.7 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF900) PGAP1 PF07819.13 CCF48382.1 - 0.047 13.4 0.0 0.074 12.8 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein Esterase PF00756.20 CCF48382.1 - 0.12 12.0 0.0 0.15 11.7 0.0 1.3 1 0 0 1 1 1 0 Putative esterase Cutinase PF01083.22 CCF48382.1 - 0.2 11.6 0.0 10 6.1 0.0 2.5 1 1 1 2 2 2 0 Cutinase Aldolase_II PF00596.21 CCF48383.1 - 8.2e-24 84.6 0.0 1.2e-23 84.0 0.0 1.2 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain DUF3533 PF12051.8 CCF48384.1 - 1.7e-93 313.6 19.9 2e-93 313.4 19.9 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3533) HemY_N PF07219.13 CCF48384.1 - 4.3 7.6 0.0 4.3 7.6 0.0 4.0 4 1 1 5 5 5 0 HemY protein N-terminus PRK PF00485.18 CCF48386.1 - 6.3e-10 39.1 0.0 9.3e-10 38.6 0.0 1.2 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family AAA_18 PF13238.6 CCF48386.1 - 0.0022 18.5 0.6 0.04 14.5 0.6 2.2 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 CCF48386.1 - 0.006 16.8 0.0 0.21 11.7 0.0 2.2 2 0 0 2 2 2 1 AAA domain ABC_tran PF00005.27 CCF48386.1 - 0.025 15.1 0.0 0.046 14.2 0.0 1.4 1 0 0 1 1 1 0 ABC transporter T2SSE PF00437.20 CCF48386.1 - 0.038 13.0 0.3 0.057 12.5 0.3 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_28 PF13521.6 CCF48386.1 - 0.11 12.8 0.0 0.24 11.6 0.0 1.8 1 0 0 1 1 1 0 AAA domain Arf PF00025.21 CCF48387.1 - 1.7e-66 223.0 0.0 1.9e-66 222.8 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 CCF48387.1 - 9.5e-11 41.4 0.1 3.9e-07 29.6 0.0 2.3 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.10 CCF48387.1 - 2.1e-09 37.1 0.0 2.7e-09 36.7 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.13 CCF48387.1 - 2.2e-08 34.3 0.0 5.4e-08 33.1 0.0 1.6 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 CCF48387.1 - 2.8e-08 33.5 0.0 3.1e-08 33.4 0.0 1.1 1 0 0 1 1 1 1 Ras family MMR_HSR1 PF01926.23 CCF48387.1 - 1.1e-07 31.9 0.0 1.8e-07 31.2 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 CCF48387.1 - 2e-05 24.1 0.0 2.2e-05 23.9 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 CCF48387.1 - 0.019 14.5 0.0 0.4 10.2 0.0 2.0 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain PduV-EutP PF10662.9 CCF48387.1 - 0.027 14.2 0.0 0.13 12.0 0.0 2.0 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation CENP-M PF11111.8 CCF48387.1 - 0.082 12.1 0.0 0.35 10.0 0.0 1.8 2 0 0 2 2 2 0 Centromere protein M (CENP-M) IF4E PF01652.18 CCF48388.1 - 5.5e-50 169.3 0.0 7.4e-50 168.8 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E TAF8_C PF10406.9 CCF48389.1 - 1.7e-05 25.3 5.6 0.0019 18.7 0.7 3.0 2 0 0 2 2 2 2 Transcription factor TFIID complex subunit 8 C-term Bromo_TP PF07524.13 CCF48389.1 - 1.8e-05 24.7 0.3 3.1e-05 23.9 0.3 1.4 1 0 0 1 1 1 1 Bromodomain associated Rhodanese PF00581.20 CCF48390.1 - 2.1e-07 31.4 0.0 2.8e-07 31.0 0.0 1.2 1 0 0 1 1 1 1 Rhodanese-like domain ECH_1 PF00378.20 CCF48391.1 - 3.5e-37 128.1 0.4 8e-37 126.9 0.4 1.6 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 CCF48391.1 - 2.7e-18 66.6 0.2 4.5e-18 65.8 0.2 1.4 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase dCache_3 PF14827.6 CCF48391.1 - 0.094 12.3 0.0 0.14 11.8 0.0 1.3 1 0 0 1 1 1 0 Double sensory domain of two-component sensor kinase UPF0444 PF15475.6 CCF48391.1 - 1.4 9.2 4.0 1.5 9.1 1.4 2.2 1 1 1 2 2 2 0 Transmembrane protein C12orf23, UPF0444 Trp_leader2 PF08056.11 CCF48392.1 - 0.15 12.0 0.2 5.9 7.0 0.0 2.2 2 0 0 2 2 2 0 Tryptophan operon leader peptide Antimicrobial12 PF08107.11 CCF48393.1 - 0.083 12.7 0.4 0.12 12.2 0.4 1.3 1 0 0 1 1 1 0 Pleurocidin family Pkinase PF00069.25 CCF48395.1 - 4.4e-56 190.2 0.0 1.7e-31 109.6 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CCF48395.1 - 5.1e-19 68.6 0.0 5.4e-17 61.9 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Elong_Iki1 PF10483.9 CCF48395.1 - 7.7e-16 58.4 0.1 1.8e-09 37.6 0.3 2.4 2 0 0 2 2 2 2 Elongator subunit Iki1 Kdo PF06293.14 CCF48395.1 - 0.00079 18.8 0.2 0.0015 17.9 0.2 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 CCF48395.1 - 0.074 12.0 0.1 0.12 11.3 0.1 1.3 1 0 0 1 1 1 0 Haspin like kinase domain bZIP_1 PF00170.21 CCF48396.1 - 2.5e-08 33.9 10.5 1.8e-07 31.2 10.6 2.1 1 1 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 CCF48396.1 - 1.3e-06 28.4 4.6 1.3e-06 28.4 4.6 1.7 1 1 1 2 2 2 1 Basic region leucine zipper RAC_head PF16717.5 CCF48396.1 - 0.0081 17.1 0.9 0.018 16.0 0.9 1.6 1 0 0 1 1 1 1 Ribosome-associated complex head domain YabA PF06156.13 CCF48396.1 - 0.012 16.2 0.3 0.029 15.0 0.3 1.6 1 0 0 1 1 1 0 Initiation control protein YabA bZIP_Maf PF03131.17 CCF48396.1 - 0.049 14.2 3.8 0.09 13.3 3.8 1.4 1 0 0 1 1 1 0 bZIP Maf transcription factor Herpes_BLRF2 PF05812.12 CCF48396.1 - 0.052 13.7 0.1 2 8.6 0.0 2.6 2 0 0 2 2 2 0 Herpesvirus BLRF2 protein ZapB PF06005.12 CCF48396.1 - 0.054 13.9 1.0 0.12 12.8 1.0 1.6 1 0 0 1 1 1 0 Cell division protein ZapB TSC22 PF01166.18 CCF48396.1 - 0.062 13.6 0.8 0.18 12.1 0.3 2.0 1 1 1 2 2 2 0 TSC-22/dip/bun family Spc7 PF08317.11 CCF48396.1 - 0.063 12.2 1.8 0.097 11.5 1.8 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein FlaC_arch PF05377.11 CCF48396.1 - 0.092 13.2 1.6 0.2 12.1 1.6 1.5 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) DUF16 PF01519.16 CCF48396.1 - 0.15 12.5 3.0 0.13 12.8 1.4 1.6 2 0 0 2 2 1 0 Protein of unknown function DUF16 SurA_N_2 PF13623.6 CCF48396.1 - 0.21 11.5 0.5 0.46 10.3 0.5 1.5 1 0 0 1 1 1 0 SurA N-terminal domain CASP_C PF08172.12 CCF48396.1 - 1.1 8.6 5.0 0.11 11.9 0.5 1.7 2 0 0 2 2 2 0 CASP C terminal Ribosomal_S20p PF01649.18 CCF48396.1 - 6.2 7.5 8.7 11 6.7 3.9 2.9 2 1 0 2 2 2 0 Ribosomal protein S20 SF1-HH PF16275.5 CCF48397.1 - 1.1e-38 132.0 1.3 2.4e-38 130.9 1.3 1.6 1 0 0 1 1 1 1 Splicing factor 1 helix-hairpin domain zf-CCHC PF00098.23 CCF48397.1 - 2.9e-11 42.9 11.5 9.2e-06 25.5 1.8 2.4 2 0 0 2 2 2 2 Zinc knuckle KH_1 PF00013.29 CCF48397.1 - 7.5e-07 28.9 0.3 1.4e-06 28.0 0.3 1.4 1 0 0 1 1 1 1 KH domain zf-CCHC_3 PF13917.6 CCF48397.1 - 1.2e-06 28.4 11.2 0.0004 20.3 3.0 2.6 1 1 1 2 2 2 2 Zinc knuckle DUF1897 PF09005.10 CCF48397.1 - 2e-06 27.2 14.0 0.00076 18.9 4.7 2.7 2 0 0 2 2 2 2 Domain of unknown function (DUF1897) zf-CCHC_2 PF13696.6 CCF48397.1 - 0.0009 19.0 11.4 0.081 12.8 3.0 2.6 2 0 0 2 2 2 2 Zinc knuckle Macoilin PF09726.9 CCF48397.1 - 0.32 9.5 3.1 0.51 8.8 3.1 1.2 1 0 0 1 1 1 0 Macoilin family zf-CCHC_6 PF15288.6 CCF48397.1 - 5.4 6.9 12.6 0.76 9.7 1.7 2.6 1 1 1 2 2 2 0 Zinc knuckle zf-Di19 PF05605.12 CCF48399.1 - 0.071 13.4 13.1 0.057 13.7 9.8 2.6 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding PRP21_like_P PF12230.8 CCF48399.1 - 0.72 9.7 2.5 0.45 10.4 0.4 1.6 2 0 0 2 2 2 0 Pre-mRNA splicing factor PRP21 like protein Syntaxin-6_N PF09177.11 CCF48401.1 - 6.3e-17 62.0 1.1 3.1e-16 59.7 0.1 2.2 2 1 0 2 2 2 1 Syntaxin 6, N-terminal Spc7 PF08317.11 CCF48401.1 - 0.05 12.5 2.3 0.29 10.0 0.9 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein SNARE PF05739.19 CCF48401.1 - 0.14 12.1 2.9 0.15 12.1 0.1 2.5 3 0 0 3 3 3 0 SNARE domain DUF4810 PF16068.5 CCF48401.1 - 0.18 12.4 0.2 0.72 10.4 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4810) Use1 PF09753.9 CCF48401.1 - 0.23 11.1 2.9 0.38 10.5 2.9 1.5 1 1 0 1 1 1 0 Membrane fusion protein Use1 DUF1664 PF07889.12 CCF48401.1 - 0.35 10.9 3.3 14 5.7 0.9 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) TFIID-31kDa PF02291.15 CCF48402.1 - 5.4e-45 152.4 0.0 6.9e-45 152.1 0.0 1.1 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 CCF48402.1 - 0.003 17.5 0.0 0.0059 16.6 0.0 1.4 1 0 0 1 1 1 1 Bromodomain associated Ribosomal_S14 PF00253.21 CCF48403.1 - 2.1e-23 81.8 0.9 8.3e-23 79.9 0.1 2.2 2 1 1 3 3 3 1 Ribosomal protein S14p/S29e QLQ PF08880.11 CCF48403.1 - 0.024 14.4 0.1 0.072 12.9 0.0 1.9 1 1 0 1 1 1 0 QLQ DUF3486 PF11985.8 CCF48403.1 - 0.033 14.6 0.0 0.045 14.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3486) SIP1 PF04938.12 CCF48404.1 - 1.9e-26 93.2 0.0 8.8e-26 91.0 0.0 1.8 1 1 0 1 1 1 1 Survival motor neuron (SMN) interacting protein 1 (SIP1) MFS_1 PF07690.16 CCF48405.1 - 5.2e-32 111.1 35.4 1.4e-29 103.2 15.3 2.2 2 0 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF48405.1 - 6.5e-17 61.5 3.7 6.5e-17 61.5 3.7 2.4 3 0 0 3 3 3 1 Sugar (and other) transporter MFS_4 PF06779.14 CCF48405.1 - 4.7e-05 22.9 1.1 4.7e-05 22.9 1.1 2.4 3 0 0 3 3 3 1 Uncharacterised MFS-type transporter YbfB TRI12 PF06609.13 CCF48405.1 - 0.003 16.1 1.3 0.0049 15.3 1.3 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) DUF2157 PF09925.9 CCF48405.1 - 0.031 14.1 10.2 0.47 10.2 0.7 3.4 3 0 0 3 3 3 0 Predicted membrane protein (DUF2157) Wzy_C PF04932.15 CCF48405.1 - 0.41 10.3 3.7 0.2 11.3 0.1 2.4 2 1 0 2 2 2 0 O-Antigen ligase COX15-CtaA PF02628.15 CCF48406.1 - 5.6e-88 295.1 15.7 4.2e-87 292.2 15.7 2.3 1 1 0 1 1 1 1 Cytochrome oxidase assembly protein Ecl1 PF12855.7 CCF48406.1 - 4 8.6 14.2 1.9 9.6 11.4 1.8 2 0 0 2 2 2 0 ECL1/2/3 zinc binding proteins Ribosomal_L19 PF01245.20 CCF48407.1 - 8e-16 58.0 0.1 1.4e-15 57.2 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L19 Not3 PF04065.15 CCF48408.1 - 8.8e-90 300.2 26.8 1.3e-89 299.6 26.8 1.3 1 0 0 1 1 1 1 Not1 N-terminal domain, CCR4-Not complex component NOT2_3_5 PF04153.18 CCF48408.1 - 5.7e-45 152.6 12.7 1.7e-44 151.1 12.7 1.9 1 0 0 1 1 1 1 NOT2 / NOT3 / NOT5 family DUF2373 PF10180.9 CCF48408.1 - 0.0064 16.3 3.7 0.016 15.1 3.7 1.6 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2373) MbeD_MobD PF04899.12 CCF48408.1 - 0.0098 16.0 1.4 0.7 10.0 0.0 2.7 2 0 0 2 2 2 1 MbeD/MobD like IL11 PF07400.11 CCF48408.1 - 0.018 14.7 1.9 0.039 13.6 1.9 1.6 1 0 0 1 1 1 0 Interleukin 11 Syntaxin_2 PF14523.6 CCF48408.1 - 0.41 11.0 12.4 0.17 12.3 5.4 3.1 3 0 0 3 3 3 0 Syntaxin-like protein DUF1419 PF07215.11 CCF48408.1 - 0.61 10.2 2.5 0.65 10.1 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1419) HR1 PF02185.16 CCF48408.1 - 3.6 7.8 17.3 0.13 12.3 4.8 3.1 3 0 0 3 3 3 0 Hr1 repeat LPP PF04728.13 CCF48408.1 - 6.3 7.3 7.8 1.2 9.6 0.3 3.6 3 0 0 3 3 3 0 Lipoprotein leucine-zipper Swi5 PF07061.11 CCF48408.1 - 8.5 6.5 8.7 22 5.2 0.3 3.1 2 0 0 2 2 2 0 Swi5 Ribonuclease_3 PF00636.26 CCF48410.1 - 1.8e-31 108.9 0.0 2.7e-15 56.9 0.0 2.8 2 0 0 2 2 2 2 Ribonuclease III domain Dicer_dimer PF03368.14 CCF48410.1 - 1.8e-18 66.5 0.1 5.2e-18 65.0 0.1 1.8 1 0 0 1 1 1 1 Dicer dimerisation domain Ribonucleas_3_3 PF14622.6 CCF48410.1 - 4.3e-16 59.3 0.0 4.1e-06 27.0 0.0 3.9 2 2 0 2 2 2 2 Ribonuclease-III-like Helicase_C PF00271.31 CCF48410.1 - 3.1e-13 50.0 0.0 7.3e-13 48.8 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 CCF48410.1 - 1.7e-09 37.7 0.0 4.6e-09 36.3 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 CCF48410.1 - 2.9e-07 30.7 0.0 8.6e-07 29.1 0.0 1.8 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit PAZ PF02170.22 CCF48410.1 - 0.016 15.0 0.0 0.034 14.0 0.0 1.5 1 0 0 1 1 1 0 PAZ domain DUF3439 PF11921.8 CCF48410.1 - 0.12 12.4 1.0 0.29 11.1 1.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) cwf21 PF08312.12 CCF48411.1 - 2.5e-15 56.3 12.2 2.5e-15 56.3 12.2 2.4 2 0 0 2 2 2 1 cwf21 domain C2 PF00168.30 CCF48412.1 - 1.2e-13 51.2 0.0 2.7e-10 40.5 0.0 2.3 2 0 0 2 2 2 2 C2 domain WLM PF08325.10 CCF48413.1 - 8.3e-30 104.3 0.1 1.6e-29 103.4 0.1 1.4 1 0 0 1 1 1 1 WLM domain ubiquitin PF00240.23 CCF48413.1 - 0.016 15.0 0.5 0.066 13.0 0.4 2.1 2 0 0 2 2 2 0 Ubiquitin family DUF45 PF01863.17 CCF48413.1 - 0.047 13.7 0.4 0.11 12.5 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function DUF45 Acyl-CoA_dh_1 PF00441.24 CCF48414.1 - 4.4e-26 91.9 4.3 6.7e-26 91.3 4.3 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 CCF48414.1 - 2e-18 66.4 0.0 4.3e-18 65.3 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 CCF48414.1 - 6.2e-11 42.9 0.0 1.3e-10 41.9 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 CCF48414.1 - 1.7e-10 41.3 4.7 2.9e-10 40.5 4.7 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain SLAC1 PF03595.17 CCF48415.1 - 7.9e-70 235.7 41.0 9.2e-70 235.4 41.0 1.0 1 0 0 1 1 1 1 Voltage-dependent anion channel HCV_NS2 PF01538.18 CCF48415.1 - 0.27 10.9 2.8 0.64 9.7 2.8 1.6 1 0 0 1 1 1 0 Hepatitis C virus non-structural protein NS2 MCM PF00493.23 CCF48416.1 - 5.6e-103 342.9 0.0 8.6e-103 342.2 0.0 1.2 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 CCF48416.1 - 3.3e-30 104.5 0.1 5.7e-30 103.8 0.1 1.3 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 CCF48416.1 - 2.5e-19 69.5 0.0 6.7e-19 68.1 0.0 1.8 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 CCF48416.1 - 9e-15 55.1 0.0 2.8e-14 53.6 0.0 1.9 1 0 0 1 1 1 1 MCM N-terminal domain AAA_5 PF07728.14 CCF48416.1 - 5.9e-08 32.8 0.0 3e-06 27.3 0.0 2.7 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 CCF48416.1 - 1.8e-07 30.7 0.1 1.8e-05 24.3 0.0 2.4 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 CCF48416.1 - 0.023 14.5 0.0 0.099 12.5 0.0 2.1 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_lid_2 PF17863.1 CCF48416.1 - 0.084 12.7 0.0 0.53 10.2 0.0 2.3 2 0 0 2 2 2 0 AAA lid domain DUF615 PF04751.14 CCF48416.1 - 0.11 12.5 0.4 0.35 10.9 0.4 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF615) HemN_C PF06969.16 CCF48416.1 - 0.15 12.2 0.2 1.4 9.0 0.2 2.5 2 0 0 2 2 2 0 HemN C-terminal domain Sigma54_activat PF00158.26 CCF48416.1 - 0.17 11.6 0.1 1.1 9.0 0.0 2.0 2 0 0 2 2 2 0 Sigma-54 interaction domain Ras PF00071.22 CCF48417.1 - 3.7e-43 146.9 0.1 5.9e-41 139.8 0.0 2.2 2 0 0 2 2 2 2 Ras family Roc PF08477.13 CCF48417.1 - 9.5e-32 109.7 0.1 2e-31 108.7 0.1 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CCF48417.1 - 2e-11 43.7 0.0 3.1e-11 43.0 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 CCF48417.1 - 3.6e-05 23.8 0.0 8e-05 22.7 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 CCF48417.1 - 0.0017 17.8 0.0 0.0049 16.3 0.0 1.8 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 CCF48417.1 - 0.011 15.0 0.0 0.022 14.1 0.0 1.4 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region AAA_16 PF13191.6 CCF48417.1 - 0.089 13.2 0.0 0.37 11.2 0.0 2.0 1 1 0 1 1 1 0 AAA ATPase domain RsgA_GTPase PF03193.16 CCF48417.1 - 0.14 12.0 0.0 0.31 10.9 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase AhpC-TSA PF00578.21 CCF48418.1 - 4.3e-31 107.4 0.0 5.6e-31 107.0 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 CCF48418.1 - 2.3e-11 43.6 0.0 2.9e-11 43.3 0.0 1.1 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.9 CCF48418.1 - 5.9e-10 38.8 0.0 1e-09 38.0 0.0 1.4 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin AhpC-TSA_2 PF13911.6 CCF48418.1 - 0.1 12.7 0.0 0.12 12.5 0.0 1.3 1 0 0 1 1 1 0 AhpC/TSA antioxidant enzyme AMMECR1 PF01871.17 CCF48419.1 - 3.4e-40 137.4 0.0 1.3e-39 135.5 0.0 1.8 1 1 0 1 1 1 1 AMMECR1 TspO_MBR PF03073.15 CCF48420.1 - 2.5e-45 153.8 10.7 2.9e-45 153.7 10.7 1.0 1 0 0 1 1 1 1 TspO/MBR family His_Phos_2 PF00328.22 CCF48421.1 - 3.5e-72 243.9 0.0 4.7e-72 243.4 0.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) PPIP5K2_N PF18086.1 CCF48421.1 - 2.6e-39 133.2 0.0 5.5e-39 132.2 0.0 1.6 1 0 0 1 1 1 1 Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain RimK PF08443.11 CCF48421.1 - 7.8e-07 28.9 0.0 1.5e-06 27.9 0.0 1.4 1 0 0 1 1 1 1 RimK-like ATP-grasp domain SBDS PF01172.18 CCF48423.1 - 1e-15 57.5 0.0 1.2e-15 57.3 0.0 1.1 1 0 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein Swi6_N PF18530.1 CCF48423.1 - 0.14 12.3 0.0 0.26 11.4 0.0 1.4 1 0 0 1 1 1 0 Swi6 N-terminal domain SNF5 PF04855.12 CCF48424.1 - 6.3e-66 222.6 1.7 2e-59 201.3 0.5 2.2 2 0 0 2 2 2 2 SNF5 / SMARCB1 / INI1 tRNA-synt_2 PF00152.20 CCF48425.1 - 8e-83 278.1 0.0 5.7e-82 275.3 0.0 1.9 1 1 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 CCF48425.1 - 2.6e-06 27.3 0.0 5e-06 26.4 0.0 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 CCF48425.1 - 0.026 14.0 0.0 1.1 8.7 0.0 2.9 3 0 0 3 3 3 0 tRNA synthetases class II core domain (F) LIM PF00412.22 CCF48426.1 - 4.6e-28 97.2 33.2 8.4e-14 51.5 2.2 5.0 4 1 0 4 4 4 4 LIM domain ATF7IP_BD PF16788.5 CCF48428.1 - 7 6.7 16.6 3.6 7.6 13.3 1.8 2 0 0 2 2 2 0 ATF-interacting protein binding domain ketoacyl-synt PF00109.26 CCF48429.1 - 2.4e-56 191.1 0.1 5.5e-56 190.0 0.1 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain PP-binding PF00550.25 CCF48429.1 - 5.7e-24 84.3 3.5 4e-12 46.3 0.2 2.7 2 0 0 2 2 2 2 Phosphopantetheine attachment site SAT PF16073.5 CCF48429.1 - 2.6e-19 69.9 1.8 1.1e-18 67.9 1.8 2.1 1 1 0 1 1 1 1 Starter unit:ACP transacylase in aflatoxin biosynthesis Thioesterase PF00975.20 CCF48429.1 - 1.5e-17 64.5 0.1 1.8e-15 57.7 0.0 3.2 3 0 0 3 3 3 1 Thioesterase domain Ketoacyl-synt_C PF02801.22 CCF48429.1 - 2.3e-13 50.2 0.2 6.2e-13 48.8 0.2 1.8 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Abhydrolase_6 PF12697.7 CCF48429.1 - 0.2 12.2 1.3 0.61 10.7 0.1 2.5 2 0 0 2 2 2 0 Alpha/beta hydrolase family zf-CCCH_6 PF18585.1 CCF48430.1 - 0.043 13.7 1.9 0.075 12.9 1.9 1.4 1 0 0 1 1 1 0 Chromatin remodeling factor Mit1 C-terminal Zn finger 2 DUF3263 PF11662.8 CCF48431.1 - 0.11 12.4 0.0 0.18 11.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3263) Zn_clus PF00172.18 CCF48432.1 - 0.0016 18.6 6.3 0.34 11.1 0.3 2.3 2 0 0 2 2 2 2 Fungal Zn(2)-Cys(6) binuclear cluster domain Dscam_C PF12355.8 CCF48432.1 - 0.31 12.0 6.4 2.6 9.0 6.4 2.7 1 0 0 1 1 1 0 Down syndrome cell adhesion molecule C terminal Ndc1_Nup PF09531.10 CCF48433.1 - 1.1e-74 252.2 9.8 1.4e-74 251.9 9.8 1.1 1 0 0 1 1 1 1 Nucleoporin protein Ndc1-Nup Sod_Fe_C PF02777.18 CCF48434.1 - 1.3e-20 73.5 0.1 1.8e-09 37.7 0.1 2.3 2 0 0 2 2 2 2 Iron/manganese superoxide dismutases, C-terminal domain ketoacyl-synt PF00109.26 CCF48435.1 - 5.5e-50 170.3 0.1 1e-49 169.4 0.1 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.21 CCF48435.1 - 5.2e-40 137.9 0.0 3e-39 135.4 0.0 2.1 2 0 0 2 2 2 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 CCF48435.1 - 1.4e-29 102.5 0.2 5e-29 100.7 0.2 2.0 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain Thioesterase PF00975.20 CCF48435.1 - 4.8e-23 82.5 0.1 1.9e-21 77.3 0.0 2.8 2 1 0 2 2 2 1 Thioesterase domain PS-DH PF14765.6 CCF48435.1 - 3.8e-18 65.8 0.0 7.8e-18 64.7 0.0 1.5 1 0 0 1 1 1 1 Polyketide synthase dehydratase Abhydrolase_6 PF12697.7 CCF48435.1 - 0.00026 21.7 0.3 0.75 10.4 0.0 2.8 2 0 0 2 2 2 2 Alpha/beta hydrolase family SAT PF16073.5 CCF48435.1 - 0.00055 19.7 0.6 0.1 12.3 0.1 3.4 3 0 0 3 3 3 1 Starter unit:ACP transacylase in aflatoxin biosynthesis Thiolase_N PF00108.23 CCF48435.1 - 0.028 13.8 0.1 0.028 13.8 0.1 1.8 2 0 0 2 2 2 0 Thiolase, N-terminal domain FSH1 PF03959.13 CCF48436.1 - 8.7e-19 68.0 0.0 1.7e-18 67.0 0.0 1.4 1 1 0 1 1 1 1 Serine hydrolase (FSH1) SNARE_assoc PF09335.11 CCF48437.1 - 2e-14 54.1 3.5 5.1e-14 52.8 3.5 1.7 1 0 0 1 1 1 1 SNARE associated Golgi protein DHC_N2 PF08393.13 CCF48437.1 - 0.2 10.7 0.0 0.3 10.2 0.0 1.1 1 0 0 1 1 1 0 Dynein heavy chain, N-terminal region 2 PI31_Prot_C PF08577.11 CCF48437.1 - 9.2 7.5 11.4 0.11 13.7 1.2 3.1 3 1 0 3 3 3 0 PI31 proteasome regulator UPF0160 PF03690.13 CCF48438.1 - 1.5e-128 428.9 0.0 1.9e-128 428.6 0.0 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0160) cobW PF02492.19 CCF48438.1 - 6.9e-35 120.2 0.0 1.1e-34 119.5 0.0 1.3 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain MeaB PF03308.16 CCF48438.1 - 0.0016 17.5 2.0 0.0079 15.2 2.0 1.9 1 1 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB Pox_A32 PF04665.12 CCF48438.1 - 0.0029 17.1 0.0 0.0048 16.4 0.0 1.2 1 0 0 1 1 1 1 Poxvirus A32 protein AAA_16 PF13191.6 CCF48438.1 - 0.015 15.7 0.1 0.051 14.0 0.0 1.9 2 0 0 2 2 2 0 AAA ATPase domain AAA_5 PF07728.14 CCF48438.1 - 0.021 14.8 0.0 0.067 13.2 0.0 1.8 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) MMR_HSR1 PF01926.23 CCF48438.1 - 0.022 14.9 0.0 0.074 13.1 0.0 2.0 1 1 0 1 1 1 0 50S ribosome-binding GTPase ABC_tran PF00005.27 CCF48438.1 - 0.025 15.1 0.0 0.052 14.1 0.0 1.5 1 0 0 1 1 1 0 ABC transporter NACHT PF05729.12 CCF48438.1 - 0.032 14.2 0.0 0.063 13.2 0.0 1.4 1 0 0 1 1 1 0 NACHT domain ATPase_2 PF01637.18 CCF48438.1 - 0.062 13.2 0.0 0.42 10.5 0.0 2.1 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea CbiA PF01656.23 CCF48438.1 - 0.08 13.0 0.0 0.29 11.2 0.0 1.9 2 0 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_22 PF13401.6 CCF48438.1 - 0.1 12.9 0.0 1.2 9.4 0.0 2.3 2 0 0 2 2 2 0 AAA domain KAP_NTPase PF07693.14 CCF48438.1 - 0.18 11.0 0.0 0.28 10.4 0.0 1.3 1 0 0 1 1 1 0 KAP family P-loop domain APH PF01636.23 CCF48439.1 - 1.3e-40 139.9 0.0 1.9e-40 139.3 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.20 CCF48439.1 - 6e-06 25.8 0.0 9.2e-06 25.2 0.0 1.2 1 0 0 1 1 1 1 Ecdysteroid kinase Choline_kinase PF01633.20 CCF48439.1 - 0.00023 20.8 0.0 0.00036 20.2 0.0 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase SLT_L PF14718.6 CCF48439.1 - 0.78 9.9 4.4 1.9 8.7 0.1 2.4 2 0 0 2 2 2 0 Soluble lytic murein transglycosylase L domain Aldedh PF00171.22 CCF48440.1 - 2.5e-75 253.8 0.0 3.3e-75 253.3 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family PhaP_Bmeg PF09602.10 CCF48440.1 - 0.2 11.5 0.1 0.35 10.8 0.1 1.3 1 0 0 1 1 1 0 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) BTB PF00651.31 CCF48441.1 - 2.2e-06 27.9 0.0 1.5e-05 25.1 0.0 2.1 2 0 0 2 2 2 1 BTB/POZ domain Acyltransferase PF01553.21 CCF48442.1 - 3.7e-32 110.8 0.0 5.5e-32 110.2 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase Glyco_hydro_3_C PF01915.22 CCF48443.1 - 4.4e-38 131.3 0.0 6.9e-38 130.7 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 CCF48443.1 - 9.3e-31 107.4 0.0 1.7e-30 106.5 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 CCF48443.1 - 7e-10 38.9 0.0 1.8e-09 37.6 0.0 1.8 1 0 0 1 1 1 1 Fibronectin type III-like domain Retrotran_gag_2 PF14223.6 CCF48444.1 - 0.00068 19.3 0.1 0.0015 18.2 0.1 1.6 1 0 0 1 1 1 1 gag-polypeptide of LTR copia-type RVT_2 PF07727.14 CCF48445.1 - 1e-32 113.7 0.0 1.6e-32 113.1 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) gag_pre-integrs PF13976.6 CCF48445.1 - 1.3e-06 28.2 0.1 3.2e-06 26.9 0.1 1.7 1 0 0 1 1 1 1 GAG-pre-integrase domain rve PF00665.26 CCF48445.1 - 5.1e-06 26.7 0.1 1.2e-05 25.5 0.1 1.6 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 CCF48445.1 - 0.18 11.9 1.0 2.4 8.3 0.0 2.5 2 0 0 2 2 2 0 Integrase zinc binding domain MoCF_biosynth PF00994.24 CCF48447.1 - 1.2e-13 51.0 0.1 4.4e-11 42.6 0.1 2.3 2 0 0 2 2 2 2 Probable molybdopterin binding domain AAA_2 PF07724.14 CCF48448.1 - 1.9e-47 161.5 0.3 8.7e-46 156.2 0.0 3.1 3 1 0 3 3 2 1 AAA domain (Cdc48 subfamily) AAA_lid_9 PF17871.1 CCF48448.1 - 6e-33 112.9 1.4 6e-33 112.9 1.4 3.4 2 1 1 3 3 2 1 AAA lid domain AAA PF00004.29 CCF48448.1 - 1.2e-25 90.4 0.0 7e-16 58.9 0.0 2.8 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) ClpB_D2-small PF10431.9 CCF48448.1 - 1.2e-17 63.8 0.7 4.3e-17 61.9 0.2 2.4 2 0 0 2 2 1 1 C-terminal, D2-small domain, of ClpB protein AAA_5 PF07728.14 CCF48448.1 - 2e-14 53.8 0.0 5.7e-09 36.1 0.0 3.3 3 1 0 3 3 2 2 AAA domain (dynein-related subfamily) Clp_N PF02861.20 CCF48448.1 - 2.5e-11 43.5 9.7 1.2e-05 25.4 0.8 4.2 4 0 0 4 4 3 2 Clp amino terminal domain, pathogenicity island component AAA_16 PF13191.6 CCF48448.1 - 1.7e-09 38.3 9.7 7.3e-05 23.2 0.0 5.3 4 3 0 5 5 4 2 AAA ATPase domain Sigma54_activat PF00158.26 CCF48448.1 - 4.2e-09 36.3 0.0 1.7e-07 31.1 0.0 2.5 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_22 PF13401.6 CCF48448.1 - 1e-06 29.1 0.2 0.041 14.2 0.0 4.5 2 2 0 2 2 2 1 AAA domain TniB PF05621.11 CCF48448.1 - 1.3e-06 28.0 0.0 0.0036 16.7 0.0 3.7 3 0 0 3 3 3 1 Bacterial TniB protein Zeta_toxin PF06414.12 CCF48448.1 - 5.7e-06 25.8 0.1 0.0032 16.8 0.0 3.1 3 0 0 3 3 2 1 Zeta toxin Mg_chelatase PF01078.21 CCF48448.1 - 4.1e-05 23.1 0.3 0.45 9.9 0.1 3.8 3 1 0 3 3 3 2 Magnesium chelatase, subunit ChlI AAA_33 PF13671.6 CCF48448.1 - 0.00014 22.1 0.1 0.83 9.8 0.0 3.4 3 0 0 3 3 2 2 AAA domain AAA_7 PF12775.7 CCF48448.1 - 0.00046 19.7 0.0 1.3 8.5 0.0 3.0 3 0 0 3 3 3 2 P-loop containing dynein motor region TsaE PF02367.17 CCF48448.1 - 0.0014 18.7 0.0 2.1 8.4 0.0 2.4 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE IstB_IS21 PF01695.17 CCF48448.1 - 0.0015 18.3 0.0 0.11 12.2 0.0 2.8 2 0 0 2 2 2 1 IstB-like ATP binding protein Torsin PF06309.11 CCF48448.1 - 0.0024 18.0 0.0 0.0073 16.4 0.0 1.8 1 0 0 1 1 1 1 Torsin RuvB_N PF05496.12 CCF48448.1 - 0.0024 17.6 0.0 4.3 7.1 0.0 3.3 3 0 0 3 3 3 1 Holliday junction DNA helicase RuvB P-loop domain RNA_helicase PF00910.22 CCF48448.1 - 0.0025 18.2 0.1 6 7.3 0.0 3.2 3 0 0 3 3 3 0 RNA helicase AAA_28 PF13521.6 CCF48448.1 - 0.0025 18.1 3.0 0.48 10.7 0.0 3.9 3 1 0 3 3 3 1 AAA domain NACHT PF05729.12 CCF48448.1 - 0.0027 17.6 0.0 2.8 7.8 0.0 2.8 2 0 0 2 2 2 1 NACHT domain AAA_19 PF13245.6 CCF48448.1 - 0.0031 17.8 0.0 0.13 12.6 0.0 3.1 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.6 CCF48448.1 - 0.0032 17.2 0.0 5.8 6.6 0.0 3.2 3 0 0 3 3 3 0 AAA domain TrwB_AAD_bind PF10412.9 CCF48448.1 - 0.0068 15.4 0.0 4.7 6.0 0.0 3.5 3 0 0 3 3 3 0 Type IV secretion-system coupling protein DNA-binding domain RsgA_GTPase PF03193.16 CCF48448.1 - 0.0077 16.1 0.3 1.9 8.4 0.0 3.0 3 0 0 3 3 2 1 RsgA GTPase ATPase_2 PF01637.18 CCF48448.1 - 0.0079 16.1 2.3 1.8 8.4 0.0 4.1 4 0 0 4 4 4 1 ATPase domain predominantly from Archaea AAA_18 PF13238.6 CCF48448.1 - 0.01 16.4 1.1 4.7 7.8 0.0 3.3 3 0 0 3 3 2 0 AAA domain Roc PF08477.13 CCF48448.1 - 0.011 16.0 0.0 2.6 8.3 0.0 2.8 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_29 PF13555.6 CCF48448.1 - 0.015 15.0 0.1 8.6 6.2 0.0 2.6 2 0 0 2 2 2 0 P-loop containing region of AAA domain EMP24_GP25L PF01105.24 CCF48448.1 - 0.017 15.1 1.9 0.036 14.0 1.9 1.5 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD DUF815 PF05673.13 CCF48448.1 - 0.023 13.9 0.0 0.8 8.8 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF815) cobW PF02492.19 CCF48448.1 - 0.032 13.8 0.1 6.8 6.2 0.0 3.1 3 0 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain ABC_tran PF00005.27 CCF48448.1 - 0.048 14.2 3.2 14 6.2 0.0 4.0 4 0 0 4 4 4 0 ABC transporter AAA_30 PF13604.6 CCF48448.1 - 0.052 13.3 1.4 1.3 8.7 0.0 3.5 3 1 0 3 3 3 0 AAA domain CbiA PF01656.23 CCF48448.1 - 0.072 13.2 0.0 3.7 7.6 0.0 3.1 2 0 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain ResIII PF04851.15 CCF48448.1 - 0.078 13.0 0.0 3.9 7.5 0.0 3.1 3 0 0 3 3 3 0 Type III restriction enzyme, res subunit AAA_3 PF07726.11 CCF48448.1 - 0.083 12.8 0.0 11 5.9 0.0 3.1 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Nre_N PF04894.12 CCF48448.1 - 0.17 11.7 0.5 0.36 10.6 0.5 1.4 1 0 0 1 1 1 0 Archaeal Nre, N-terminal Uds1 PF15456.6 CCF48448.1 - 1.7 8.8 10.8 2.7 8.2 8.7 2.5 2 0 0 2 2 1 0 Up-regulated During Septation DUF16 PF01519.16 CCF48448.1 - 2.6 8.6 8.9 4.3 7.9 4.1 3.7 3 1 0 3 3 2 0 Protein of unknown function DUF16 AAA_25 PF13481.6 CCF48448.1 - 6.1 6.4 7.9 3.9 7.0 0.0 3.4 4 0 0 4 4 3 0 AAA domain CDH-cyt PF16010.5 CCF48449.1 - 7.2e-10 38.8 4.2 1.4e-09 37.9 4.2 1.4 1 0 0 1 1 1 1 Cytochrome domain of cellobiose dehydrogenase Cytochrom_B561 PF03188.16 CCF48449.1 - 1.1e-09 38.6 11.4 1.1e-09 38.6 11.4 2.0 2 0 0 2 2 2 1 Eukaryotic cytochrome b561 DOMON PF03351.17 CCF48449.1 - 5.8e-05 23.3 0.2 9.3e-05 22.6 0.2 1.4 1 0 0 1 1 1 1 DOMON domain DUF4079 PF13301.6 CCF48449.1 - 0.00019 21.6 14.8 0.00032 20.8 12.0 2.7 2 1 0 2 2 2 1 Protein of unknown function (DUF4079) DUF2427 PF10348.9 CCF48449.1 - 0.0006 19.6 3.5 0.0006 19.6 3.5 2.2 3 0 0 3 3 3 1 Domain of unknown function (DUF2427) OpgC_C PF10129.9 CCF48449.1 - 0.054 12.4 11.9 0.12 11.2 11.9 1.6 1 0 0 1 1 1 0 OpgC protein Ndc1_Nup PF09531.10 CCF48449.1 - 0.081 11.6 3.3 0.16 10.6 3.3 1.5 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF973 PF06157.11 CCF48449.1 - 0.42 9.6 4.8 0.64 9.0 4.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF973) DUF420 PF04238.12 CCF48449.1 - 4.6 7.5 13.0 0.63 10.3 8.0 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF420) E1-E2_ATPase PF00122.20 CCF48450.1 - 5.9e-44 149.7 2.7 4.3e-43 146.9 0.5 2.4 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 CCF48450.1 - 9.1e-36 123.3 7.2 9.1e-36 123.3 7.2 3.2 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 CCF48450.1 - 1.1e-20 74.8 0.0 1.1e-09 38.9 0.0 3.3 2 1 1 3 3 3 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 CCF48450.1 - 3.1e-15 56.0 0.0 7.8e-15 54.7 0.0 1.7 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 CCF48450.1 - 4.2e-11 42.4 0.1 1.3e-10 40.8 0.0 2.0 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 CCF48450.1 - 0.00068 19.5 0.4 0.0013 18.6 0.4 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase DUF2207 PF09972.9 CCF48450.1 - 0.0018 17.1 0.7 0.51 9.0 0.1 2.5 2 0 0 2 2 2 2 Predicted membrane protein (DUF2207) HAD PF12710.7 CCF48450.1 - 0.064 13.6 0.0 4.5 7.6 0.0 2.8 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase AJAP1_PANP_C PF15298.6 CCF48450.1 - 0.099 12.8 0.0 0.19 11.9 0.0 1.4 1 0 0 1 1 1 0 AJAP1/PANP C-terminus DUF805 PF05656.14 CCF48450.1 - 0.14 12.5 0.1 0.14 12.5 0.1 3.5 3 1 0 3 3 2 0 Protein of unknown function (DUF805) COX15-CtaA PF02628.15 CCF48450.1 - 0.21 10.6 2.7 1.3 8.0 0.2 2.3 2 0 0 2 2 2 0 Cytochrome oxidase assembly protein DUF4181 PF13789.6 CCF48450.1 - 4.5 7.6 8.1 13 6.1 0.3 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4181) Glyco_hydro_79C PF16862.5 CCF48451.1 - 2.4e-18 66.9 2.9 3.8e-18 66.3 0.5 2.3 2 0 0 2 2 2 1 Glycosyl hydrolase family 79 C-terminal beta domain Orthoreo_P10 PF07204.11 CCF48451.1 - 0.023 14.7 0.2 0.057 13.4 0.2 1.6 1 0 0 1 1 1 0 Orthoreovirus membrane fusion protein p10 Herpes_gE PF02480.16 CCF48451.1 - 0.03 13.1 0.1 0.052 12.3 0.1 1.4 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E Shisa PF13908.6 CCF48451.1 - 0.03 14.6 0.7 0.16 12.2 0.0 2.1 1 1 1 2 2 2 0 Wnt and FGF inhibitory regulator Mid2 PF04478.12 CCF48451.1 - 0.091 12.6 0.0 0.18 11.6 0.0 1.4 1 0 0 1 1 1 0 Mid2 like cell wall stress sensor Rubella_E2 PF05749.11 CCF48451.1 - 9.4 5.6 12.7 0.61 9.5 2.2 2.5 3 0 0 3 3 3 0 Rubella membrane glycoprotein E2 RVT_2 PF07727.14 CCF48453.1 - 5.3e-45 153.9 0.2 7.5e-45 153.5 0.2 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) AAA_12 PF13087.6 CCF48454.1 - 1.8e-40 138.7 0.1 2.9e-40 138.0 0.1 1.3 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 CCF48454.1 - 7.6e-26 91.4 0.0 1.5e-25 90.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain zf-CCCH_4 PF18044.1 CCF48454.1 - 2.5e-12 46.3 16.3 3.2e-07 30.0 3.0 3.4 2 0 0 2 2 2 2 CCCH-type zinc finger AAA_19 PF13245.6 CCF48454.1 - 1.2e-11 45.2 0.0 4.1e-11 43.4 0.0 2.0 1 1 0 1 1 1 1 AAA domain zf-CCCH PF00642.24 CCF48454.1 - 2.9e-11 43.0 14.2 2.9e-06 27.0 3.0 3.0 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) AAA_30 PF13604.6 CCF48454.1 - 2e-08 34.2 0.1 0.00043 20.1 0.0 2.4 2 0 0 2 2 2 2 AAA domain zf_CCCH_4 PF18345.1 CCF48454.1 - 5.7e-08 32.6 21.2 3.3e-06 27.0 4.4 3.0 2 0 0 2 2 2 2 Zinc finger domain DUF2075 PF09848.9 CCF48454.1 - 2.4e-06 27.1 0.2 0.019 14.2 0.0 2.7 3 0 0 3 3 3 2 Uncharacterized conserved protein (DUF2075) Torus PF16131.5 CCF48454.1 - 1.4e-05 25.8 9.1 0.029 15.1 1.4 2.8 1 1 1 2 2 2 2 Torus domain Viral_helicase1 PF01443.18 CCF48454.1 - 7.6e-05 22.6 0.1 0.99 9.1 0.0 3.4 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase UvrD-helicase PF00580.21 CCF48454.1 - 0.0002 21.0 0.0 0.00056 19.5 0.0 1.8 1 1 0 1 1 1 1 UvrD/REP helicase N-terminal domain AAA_26 PF13500.6 CCF48454.1 - 0.07 12.9 0.1 0.16 11.8 0.1 1.5 1 0 0 1 1 1 0 AAA domain ResIII PF04851.15 CCF48454.1 - 0.087 12.8 0.0 0.22 11.5 0.0 1.6 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit DUF4372 PF14294.6 CCF48454.1 - 0.11 12.6 0.1 0.42 10.8 0.1 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4372) T2SSE PF00437.20 CCF48454.1 - 0.12 11.4 0.1 0.24 10.4 0.1 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein gag_pre-integrs PF13976.6 CCF48455.1 - 0.00016 21.4 1.8 0.0003 20.6 1.8 1.5 1 0 0 1 1 1 1 GAG-pre-integrase domain DUF3817 PF12823.7 CCF48455.1 - 0.14 13.0 0.4 0.26 12.1 0.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3817) zf-CCHC PF00098.23 CCF48456.1 - 0.17 12.1 3.0 0.44 10.7 3.0 1.8 1 0 0 1 1 1 0 Zinc knuckle rve PF00665.26 CCF48458.1 - 2.7e-11 43.7 0.0 6.4e-11 42.5 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain MiaE PF06175.11 CCF48458.1 - 0.045 13.3 0.2 0.089 12.4 0.2 1.4 1 0 0 1 1 1 0 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE) DUF1298 PF06974.13 CCF48458.1 - 0.049 13.6 0.0 0.19 11.7 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1298) Retrotran_gag_2 PF14223.6 CCF48458.1 - 0.057 13.1 0.0 0.17 11.6 0.0 1.8 1 0 0 1 1 1 0 gag-polypeptide of LTR copia-type zf-CRD PF17979.1 CCF48458.1 - 0.59 10.2 12.4 0.12 12.5 3.4 3.1 4 0 0 4 4 4 0 Cysteine rich domain with multizinc binding regions RVT_2 PF07727.14 CCF48459.1 - 3.9e-18 66.0 0.1 4.8e-18 65.7 0.1 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Iron_traffic PF04362.14 CCF48461.1 - 0.32 10.7 3.5 0.18 11.5 1.5 1.6 2 0 0 2 2 2 0 Bacterial Fe(2+) trafficking Abhydrolase_6 PF12697.7 CCF48462.1 - 0.00036 21.2 0.1 0.00059 20.5 0.1 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_3 PF07859.13 CCF48462.1 - 0.0017 18.2 0.1 0.0027 17.6 0.1 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold DUF1180 PF06679.12 CCF48462.1 - 0.069 13.6 0.4 0.069 13.6 0.4 1.8 2 1 1 3 3 3 0 Protein of unknown function (DUF1180) Hydrolase_4 PF12146.8 CCF48462.1 - 0.088 12.1 0.0 0.16 11.2 0.0 1.4 1 0 0 1 1 1 0 Serine aminopeptidase, S33 zf-Tim10_DDP PF02953.15 CCF48463.1 - 1.3e-19 69.6 3.8 1.3e-19 69.6 3.8 2.0 2 1 1 3 3 3 1 Tim10/DDP family zinc finger eIF-6 PF01912.18 CCF48464.1 - 4e-80 267.9 0.2 7.1e-80 267.1 0.2 1.4 1 1 1 2 2 2 1 eIF-6 family PRKCSH-like PF12999.7 CCF48465.1 - 4.5e-45 153.6 6.5 4.5e-45 153.6 6.5 1.9 1 1 1 2 2 2 1 Glucosidase II beta subunit-like PRKCSH_1 PF13015.6 CCF48465.1 - 1.2e-29 103.0 1.0 4.1e-29 101.3 0.3 2.0 2 0 0 2 2 2 1 Glucosidase II beta subunit-like protein PRKCSH PF07915.13 CCF48465.1 - 7.5e-10 39.7 2.4 7.5e-10 39.7 2.4 2.0 2 0 0 2 2 2 1 Glucosidase II beta subunit-like protein Effector_1 PF04518.12 CCF48465.1 - 0.069 12.2 4.2 0.12 11.4 4.2 1.3 1 0 0 1 1 1 0 Effector from type III secretion system Fmp27_WPPW PF10359.9 CCF48465.1 - 0.12 11.2 5.3 0.24 10.2 5.3 1.4 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain DUF5595 PF18077.1 CCF48465.1 - 0.32 11.1 2.9 0.45 10.6 0.2 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF5595) Ldl_recept_a PF00057.18 CCF48465.1 - 0.51 10.6 17.0 2.7 8.3 1.8 3.5 3 0 0 3 3 3 0 Low-density lipoprotein receptor domain class A PriC PF07445.12 CCF48465.1 - 0.76 9.7 12.5 0.3 11.0 8.6 2.1 2 0 0 2 2 2 0 Primosomal replication protein priC DUF1690 PF07956.11 CCF48465.1 - 9.4 6.7 9.9 13 6.2 0.2 2.5 2 0 0 2 2 2 0 Protein of Unknown function (DUF1690) Tctex-1 PF03645.13 CCF48466.1 - 0.00024 21.3 0.0 0.0004 20.6 0.0 1.3 1 0 0 1 1 1 1 Tctex-1 family RNA_Me_trans PF04252.13 CCF48467.1 - 1.4e-70 236.9 0.0 1.7e-70 236.7 0.0 1.1 1 0 0 1 1 1 1 Predicted SAM-dependent RNA methyltransferase GTP_cyclohydroI PF01227.22 CCF48468.1 - 8.8e-73 243.5 0.1 1.2e-72 243.1 0.1 1.1 1 0 0 1 1 1 1 GTP cyclohydrolase I QueF PF14489.6 CCF48468.1 - 0.002 18.3 0.0 0.0059 16.7 0.0 1.8 2 0 0 2 2 2 1 QueF-like protein HATPase_c_2 PF13581.6 CCF48468.1 - 0.019 14.9 0.1 0.052 13.5 0.1 1.8 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain BolA PF01722.18 CCF48469.1 - 1.2e-11 44.7 0.0 3.8e-11 43.1 0.0 1.8 1 1 0 1 1 1 1 BolA-like protein Ribosomal_S25 PF03297.15 CCF48470.1 - 4.8e-39 132.6 2.4 5.2e-39 132.5 2.4 1.0 1 0 0 1 1 1 1 S25 ribosomal protein HTH_24 PF13412.6 CCF48470.1 - 0.055 13.0 0.2 0.099 12.2 0.2 1.3 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding Mt_ATP-synt_D PF05873.12 CCF48471.1 - 3.2e-17 62.8 2.7 3.6e-17 62.6 2.7 1.0 1 0 0 1 1 1 1 ATP synthase D chain, mitochondrial (ATP5H) DivIC PF04977.15 CCF48471.1 - 0.015 15.0 4.3 0.34 10.7 0.4 2.4 2 0 0 2 2 2 0 Septum formation initiator T3SS_needle_E PF08988.10 CCF48471.1 - 0.03 14.5 4.2 3.6 7.8 0.8 2.4 2 0 0 2 2 2 0 Type III secretion system, cytoplasmic E component of needle RPW8 PF05659.11 CCF48471.1 - 0.035 13.8 1.5 0.36 10.5 0.5 2.3 2 1 0 2 2 2 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 Syntaxin PF00804.25 CCF48471.1 - 0.054 13.2 7.9 0.38 10.4 7.9 2.2 1 1 0 1 1 1 0 Syntaxin Peptidase_M17_N PF02789.17 CCF48471.1 - 0.06 13.2 2.0 0.062 13.2 0.2 1.9 2 0 0 2 2 2 0 Cytosol aminopeptidase family, N-terminal domain PDT PF00800.18 CCF48471.1 - 0.12 12.2 2.5 0.16 11.7 2.5 1.3 1 1 0 1 1 1 0 Prephenate dehydratase DUF948 PF06103.11 CCF48471.1 - 0.15 12.3 4.9 2.1 8.6 1.2 2.9 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) DUF2408 PF10303.9 CCF48471.1 - 0.16 12.5 6.3 1.9 9.1 6.3 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF2408) Prominin PF05478.11 CCF48471.1 - 0.17 9.8 2.0 0.2 9.6 2.0 1.1 1 0 0 1 1 1 0 Prominin CT_C_D PF02682.16 CCF48471.1 - 0.24 11.1 0.7 0.33 10.7 0.7 1.2 1 0 0 1 1 1 0 Carboxyltransferase domain, subdomain C and D Prefoldin_2 PF01920.20 CCF48471.1 - 0.35 10.9 9.6 4.5 7.3 9.6 2.2 1 1 0 1 1 1 0 Prefoldin subunit Rx_N PF18052.1 CCF48471.1 - 0.35 11.2 5.3 1.4 9.2 0.3 2.6 1 1 0 2 2 2 0 Rx N-terminal domain GAS PF13851.6 CCF48471.1 - 0.47 9.8 8.8 1.3 8.4 8.9 1.6 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding PRP1_N PF06424.12 CCF48471.1 - 0.57 10.6 6.0 9.4 6.6 5.9 2.2 1 1 1 2 2 2 0 PRP1 splicing factor, N-terminal TPR_MLP1_2 PF07926.12 CCF48471.1 - 0.88 9.6 10.7 2.5 8.2 1.4 2.2 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein DUF2203 PF09969.9 CCF48471.1 - 1.1 10.0 5.6 21 5.9 5.6 2.2 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) FlxA PF14282.6 CCF48471.1 - 1.1 9.2 13.8 3.8 7.5 2.0 2.2 1 1 0 2 2 2 0 FlxA-like protein THOC7 PF05615.13 CCF48471.1 - 1.3 9.4 8.6 1.2 9.4 1.3 2.1 1 1 1 2 2 2 0 Tho complex subunit 7 ZapB PF06005.12 CCF48471.1 - 1.7 9.2 7.1 34 5.0 7.1 2.2 1 1 0 1 1 1 0 Cell division protein ZapB Spc24 PF08286.11 CCF48471.1 - 2.2 8.6 6.8 5.2 7.4 1.5 2.2 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 DUF2570 PF10828.8 CCF48471.1 - 2.6 7.9 9.0 1.2 9.0 2.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2570) cNMP_binding PF00027.29 CCF48472.1 - 4.7e-37 125.9 0.7 5e-18 65.0 0.1 2.7 2 1 0 2 2 2 2 Cyclic nucleotide-binding domain RIIa PF02197.17 CCF48472.1 - 1.3e-16 59.9 0.2 2.7e-16 58.9 0.2 1.6 1 0 0 1 1 1 1 Regulatory subunit of type II PKA R-subunit Cupin_2 PF07883.11 CCF48472.1 - 0.067 12.9 0.5 2.9 7.7 0.1 2.6 2 0 0 2 2 2 0 Cupin domain SR-25 PF10500.9 CCF48472.1 - 0.62 9.6 4.2 1.1 8.8 4.2 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF5407 PF17401.2 CCF48473.1 - 0.17 12.1 0.1 0.28 11.5 0.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5407) Aft1_HRA PF11786.8 CCF48474.1 - 8.7e-28 96.5 10.4 8.7e-28 96.5 10.4 4.3 4 1 1 5 5 5 1 Aft1 HRA domain bZIP_1 PF00170.21 CCF48474.1 - 6.3e-10 39.0 8.7 1.2e-09 38.1 8.7 1.4 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 CCF48474.1 - 1.3e-06 28.4 9.1 3.3e-06 27.1 9.1 1.7 1 0 0 1 1 1 1 Basic region leucine zipper Aft1_OSA PF11785.8 CCF48474.1 - 0.00027 21.3 1.9 0.00027 21.3 1.9 3.5 2 0 0 2 2 2 1 Aft1 osmotic stress response (OSM) domain bZIP_Maf PF03131.17 CCF48474.1 - 0.00043 20.7 4.6 0.00043 20.7 4.6 1.9 2 0 0 2 2 2 1 bZIP Maf transcription factor TSC22 PF01166.18 CCF48474.1 - 0.036 14.4 0.1 0.13 12.6 0.1 1.9 1 0 0 1 1 1 0 TSC-22/dip/bun family HALZ PF02183.18 CCF48474.1 - 0.041 14.1 0.6 0.077 13.2 0.6 1.4 1 0 0 1 1 1 0 Homeobox associated leucine zipper Nnf1 PF03980.14 CCF48474.1 - 0.051 13.9 0.6 0.051 13.9 0.6 1.9 2 0 0 2 2 2 0 Nnf1 THOC7 PF05615.13 CCF48474.1 - 0.11 12.8 1.2 0.21 11.9 1.2 1.4 1 0 0 1 1 1 0 Tho complex subunit 7 Shugoshin_N PF07558.11 CCF48474.1 - 0.13 12.2 0.7 0.26 11.2 0.7 1.6 1 0 0 1 1 1 0 Shugoshin N-terminal coiled-coil region TAL_FSA PF00923.19 CCF48476.1 - 2.9e-32 112.2 0.0 4.5e-32 111.5 0.0 1.3 1 0 0 1 1 1 1 Transaldolase/Fructose-6-phosphate aldolase Cupin_2 PF07883.11 CCF48477.1 - 0.00011 21.8 1.5 0.078 12.7 0.0 3.5 4 0 0 4 4 4 2 Cupin domain Cupin_3 PF05899.12 CCF48477.1 - 0.0046 16.6 0.0 2.5 7.8 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF861) PMI_typeI PF01238.21 CCF48477.1 - 0.0092 15.2 0.0 0.014 14.6 0.0 1.2 1 0 0 1 1 1 1 Phosphomannose isomerase type I AraC_binding PF02311.19 CCF48477.1 - 0.019 14.9 0.6 7.1 6.5 0.0 2.7 3 0 0 3 3 3 0 AraC-like ligand binding domain Cupin_1 PF00190.22 CCF48477.1 - 0.02 14.5 0.0 0.075 12.6 0.0 1.9 2 0 0 2 2 2 0 Cupin HutD PF05962.11 CCF48477.1 - 0.047 13.7 0.1 0.085 12.8 0.1 1.4 1 0 0 1 1 1 0 HutD JmjC PF02373.22 CCF48477.1 - 0.2 12.1 0.0 0.33 11.4 0.0 1.3 1 0 0 1 1 1 0 JmjC domain, hydroxylase Hydrolase_4 PF12146.8 CCF48478.1 - 1.5e-11 44.1 0.5 4.3e-08 32.7 0.1 2.2 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 CCF48478.1 - 8.2e-08 32.0 3.8 8.8e-07 28.6 0.2 2.1 2 0 0 2 2 2 2 Prolyl oligopeptidase family Abhydrolase_1 PF00561.20 CCF48478.1 - 2.6e-07 30.6 1.7 9.5e-05 22.2 0.5 2.3 1 1 1 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CCF48478.1 - 7.6e-07 30.0 0.0 1.7e-06 28.8 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family DUF1749 PF08538.10 CCF48478.1 - 1.3e-05 24.5 0.1 0.00012 21.3 0.1 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF1749) FSH1 PF03959.13 CCF48478.1 - 0.0019 17.9 0.0 0.0058 16.3 0.0 1.8 1 1 1 2 2 2 1 Serine hydrolase (FSH1) Peptidase_S15 PF02129.18 CCF48478.1 - 0.0032 17.1 0.8 0.2 11.2 0.1 2.3 2 1 0 2 2 2 2 X-Pro dipeptidyl-peptidase (S15 family) Retrotran_gag_3 PF14244.6 CCF48480.1 - 0.063 13.1 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 gag-polypeptide of LTR copia-type DUF4219 PF13961.6 CCF48480.1 - 0.1 12.3 0.3 0.16 11.6 0.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4219) Chromo PF00385.24 CCF48482.1 - 5e-10 39.1 0.1 1.4e-09 37.7 0.1 1.8 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain rve PF00665.26 CCF48482.1 - 7.1e-10 39.1 0.0 1.2e-09 38.4 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 CCF48482.1 - 0.00053 20.0 0.7 0.0014 18.7 0.7 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain WRNPLPNID PF15017.6 CCF48484.1 - 0.0093 16.8 1.7 0.022 15.6 1.7 1.7 1 0 0 1 1 1 1 Putative WW-binding domain and destruction box gag_pre-integrs PF13976.6 CCF48485.1 - 1.5e-06 28.0 0.0 4.1e-06 26.6 0.0 1.9 1 0 0 1 1 1 1 GAG-pre-integrase domain DEAD_assoc PF08494.11 CCF48485.1 - 0.016 15.0 0.0 0.035 13.9 0.0 1.5 1 0 0 1 1 1 0 DEAD/H associated PIGA PF08288.12 CCF48486.1 - 2.7e-43 146.5 0.4 5.1e-43 145.6 0.4 1.5 1 0 0 1 1 1 1 PIGA (GPI anchor biosynthesis) Glyco_transf_4 PF13439.6 CCF48486.1 - 1.2e-27 97.0 0.6 2e-27 96.3 0.6 1.4 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glycos_transf_1 PF00534.20 CCF48486.1 - 4.3e-23 81.7 0.0 6.9e-23 81.0 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 CCF48486.1 - 4.9e-20 72.3 0.0 1.1e-19 71.2 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 CCF48486.1 - 3e-12 47.3 0.2 8.4e-12 45.8 0.0 1.9 2 0 0 2 2 2 1 Glycosyl transferase 4-like domain Glyco_trans_4_2 PF13477.6 CCF48486.1 - 1.6e-05 24.9 0.0 2.9e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase 4-like Glyco_trans_1_2 PF13524.6 CCF48486.1 - 0.015 15.7 0.0 0.06 13.8 0.0 2.0 2 0 0 2 2 2 0 Glycosyl transferases group 1 RRM_1 PF00076.22 CCF48487.1 - 1.5e-20 72.7 0.0 2.2e-20 72.2 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 CCF48487.1 - 0.0038 16.8 0.0 0.0055 16.3 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GRP PF07172.11 CCF48487.1 - 0.23 12.2 10.8 0.058 14.1 6.9 2.0 2 0 0 2 2 2 0 Glycine rich protein family DUF2428 PF10350.9 CCF48488.1 - 2.8e-68 230.2 0.9 5.9e-68 229.1 0.1 2.1 2 0 0 2 2 2 1 Putative death-receptor fusion protein (DUF2428) HEAT PF02985.22 CCF48488.1 - 0.0017 18.4 8.8 1.1 9.7 0.1 5.3 5 0 0 5 5 5 2 HEAT repeat HEAT_2 PF13646.6 CCF48488.1 - 5.2 7.5 12.2 0.57 10.6 0.3 4.8 4 1 0 4 4 4 0 HEAT repeats Yip1 PF04893.17 CCF48489.1 - 3.1e-08 33.5 11.0 5.8e-08 32.6 11.0 1.5 1 0 0 1 1 1 1 Yip1 domain DUF21 PF01595.20 CCF48490.1 - 4.1e-38 130.8 3.3 4.9e-38 130.6 0.6 2.0 2 0 0 2 2 2 1 Cyclin M transmembrane N-terminal domain CBS PF00571.28 CCF48490.1 - 4.4e-05 23.9 0.8 0.25 11.8 0.0 3.2 3 0 0 3 3 3 2 CBS domain DUF1772 PF08592.11 CCF48490.1 - 0.031 14.6 0.2 1 9.7 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1772) TRP PF06011.12 CCF48491.1 - 2.5e-62 211.0 16.6 3.8e-62 210.4 16.6 1.1 1 0 0 1 1 1 1 Transient receptor potential (TRP) ion channel TRP_N PF14558.6 CCF48491.1 - 9.2e-29 100.6 0.1 1.4e-28 100.0 0.1 1.3 1 0 0 1 1 1 1 ML-like domain OAD_gamma PF04277.13 CCF48491.1 - 1.9 9.1 7.1 2.7 8.7 2.8 2.8 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain GEMIN8 PF15348.6 CCF48493.1 - 0.0018 18.6 0.0 0.0079 16.5 0.0 2.1 1 1 0 1 1 1 1 Gemini of Cajal bodies-associated protein 8 DASH_Duo1 PF08651.10 CCF48494.1 - 3e-20 71.7 0.1 5.8e-20 70.8 0.1 1.5 1 0 0 1 1 1 1 DASH complex subunit Duo1 ABA_GPCR PF12430.8 CCF48495.1 - 1.2e-46 158.8 8.4 1.2e-46 158.8 8.4 1.9 2 0 0 2 2 2 1 Abscisic acid G-protein coupled receptor GPHR_N PF12537.8 CCF48495.1 - 2.3e-17 62.9 0.0 5.1e-16 58.5 0.0 2.5 2 0 0 2 2 2 1 The Golgi pH Regulator (GPHR) Family N-terminal TMF_DNA_bd PF12329.8 CCF48496.1 - 0.00087 19.2 4.0 0.00087 19.2 4.0 5.1 3 1 2 5 5 5 2 TATA element modulatory factor 1 DNA binding Chibby PF14645.6 CCF48496.1 - 0.0052 17.2 3.4 0.6 10.5 0.3 3.8 3 0 0 3 3 3 1 Chibby family JIP_LZII PF16471.5 CCF48496.1 - 0.0055 16.9 3.6 0.0055 16.9 3.6 5.0 5 0 0 5 5 5 1 JNK-interacting protein leucine zipper II ZapB PF06005.12 CCF48496.1 - 0.0072 16.7 0.6 0.0072 16.7 0.6 5.5 4 1 1 5 5 4 2 Cell division protein ZapB GIT_CC PF16559.5 CCF48496.1 - 0.016 15.1 13.8 0.031 14.1 1.0 4.0 4 0 0 4 4 4 0 GIT coiled-coil Rho guanine nucleotide exchange factor YabA PF06156.13 CCF48496.1 - 0.032 14.9 0.4 0.032 14.9 0.4 5.2 4 1 2 6 6 5 0 Initiation control protein YabA SKA2 PF16740.5 CCF48496.1 - 0.17 11.6 21.5 0.071 12.9 0.8 3.8 4 0 0 4 4 4 0 Spindle and kinetochore-associated protein 2 TrmB PF01978.19 CCF48496.1 - 0.18 11.7 1.4 11 6.0 0.5 2.8 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB DUF4094 PF13334.6 CCF48496.1 - 0.19 12.2 7.0 10 6.6 0.9 3.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4094) DASH_Dam1 PF08653.10 CCF48496.1 - 0.32 10.8 1.9 26 4.7 0.0 2.9 2 0 0 2 2 2 0 DASH complex subunit Dam1 DUF5082 PF16888.5 CCF48496.1 - 0.45 10.8 18.6 0.52 10.6 3.3 3.9 2 1 0 3 3 3 0 Domain of unknown function (DUF5082) DUF4201 PF13870.6 CCF48496.1 - 0.67 9.7 26.9 2.1 8.0 11.7 4.0 3 1 1 4 4 4 0 Domain of unknown function (DUF4201) Spectrin PF00435.21 CCF48496.1 - 0.72 10.4 21.7 3.8 8.0 1.0 4.8 4 1 1 5 5 5 0 Spectrin repeat DUF1664 PF07889.12 CCF48496.1 - 0.93 9.5 14.0 0.17 11.9 3.9 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) KASH_CCD PF14662.6 CCF48496.1 - 1.3 8.8 30.8 0.59 9.9 8.4 4.5 3 1 1 4 4 4 0 Coiled-coil region of CCDC155 or KASH CENP-H PF05837.12 CCF48496.1 - 2.3 8.6 26.3 0.18 12.2 1.1 4.9 3 1 1 4 4 4 0 Centromere protein H (CENP-H) Prp19 PF08606.11 CCF48496.1 - 5.1 7.2 9.1 1.6 8.8 0.1 3.5 3 0 0 3 3 3 0 Prp19/Pso4-like TMF_TATA_bd PF12325.8 CCF48496.1 - 9.8 6.4 38.3 2.3 8.5 0.5 4.7 3 1 1 4 4 4 0 TATA element modulatory factor 1 TATA binding DUF1749 PF08538.10 CCF48497.1 - 1.4e-61 208.3 0.0 1.7e-59 201.4 0.0 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF1749) Ser_hydrolase PF06821.13 CCF48497.1 - 6.9e-06 26.0 0.2 0.00016 21.6 0.0 2.1 2 0 0 2 2 2 1 Serine hydrolase Abhydrolase_6 PF12697.7 CCF48497.1 - 0.00026 21.7 0.2 0.00034 21.3 0.2 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Chlorophyllase2 PF12740.7 CCF48497.1 - 0.00069 18.6 0.0 0.0011 17.9 0.0 1.3 1 0 0 1 1 1 1 Chlorophyllase enzyme Peptidase_S9 PF00326.21 CCF48497.1 - 0.0045 16.5 0.1 1.2 8.5 0.1 2.2 2 0 0 2 2 2 2 Prolyl oligopeptidase family DUF900 PF05990.12 CCF48497.1 - 0.0071 15.9 0.0 0.011 15.3 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF900) LIDHydrolase PF10230.9 CCF48497.1 - 0.0082 15.7 0.0 0.93 9.0 0.0 2.1 2 0 0 2 2 2 1 Lipid-droplet associated hydrolase Hydrolase_4 PF12146.8 CCF48497.1 - 0.017 14.4 0.0 0.034 13.4 0.0 1.6 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 CCF48497.1 - 0.056 13.1 0.0 0.11 12.1 0.0 1.6 1 1 0 1 1 1 0 alpha/beta hydrolase fold Chlorophyllase PF07224.11 CCF48497.1 - 0.063 12.3 0.0 0.094 11.7 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase LCAT PF02450.15 CCF48497.1 - 0.14 11.3 0.0 0.22 10.7 0.0 1.2 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase CS PF04969.16 CCF48498.1 - 0.00081 20.4 0.0 0.021 15.9 0.0 2.7 1 1 0 1 1 1 1 CS domain CPSase_sm_chain PF00988.22 CCF48499.1 - 5.9e-43 145.8 0.0 9.1e-43 145.1 0.0 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain GATase PF00117.28 CCF48499.1 - 1.1e-38 132.9 0.0 1.7e-38 132.3 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 CCF48499.1 - 1.9e-06 27.8 0.6 4.5e-05 23.3 0.6 2.2 1 1 0 1 1 1 1 Peptidase C26 Peptidase_M22 PF00814.25 CCF48499.1 - 0.14 11.9 0.0 0.23 11.1 0.0 1.3 1 0 0 1 1 1 0 Glycoprotease family NAD_Gly3P_dh_C PF07479.14 CCF48500.1 - 7.4e-48 162.4 0.1 1.3e-47 161.7 0.1 1.4 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus NAD_Gly3P_dh_N PF01210.23 CCF48500.1 - 3e-47 160.5 0.1 6.1e-47 159.5 0.1 1.5 2 0 0 2 2 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus F420_oxidored PF03807.17 CCF48500.1 - 0.0023 18.5 0.2 0.04 14.5 0.2 2.5 1 1 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent PAS PF00989.25 CCF48500.1 - 0.084 12.9 0.0 0.35 10.9 0.0 2.0 2 0 0 2 2 2 0 PAS fold CASP_C PF08172.12 CCF48501.1 - 1.8e-80 270.0 0.2 1.8e-80 270.0 0.2 3.6 2 1 0 2 2 2 1 CASP C terminal ZapB PF06005.12 CCF48501.1 - 0.1 13.1 0.4 0.1 13.1 0.4 8.8 5 4 1 6 6 6 0 Cell division protein ZapB DUF720 PF05302.11 CCF48501.1 - 0.41 10.5 13.0 11 5.9 7.9 3.2 2 1 0 2 2 2 0 Protein of unknown function (DUF720) KLRAQ PF10205.9 CCF48501.1 - 0.46 10.8 0.0 0.46 10.8 0.0 6.4 5 3 1 6 6 6 0 Predicted coiled-coil domain-containing protein PKcGMP_CC PF16808.5 CCF48501.1 - 0.5 10.2 17.6 2.1 8.2 1.4 5.2 4 0 0 4 4 4 0 Coiled-coil N-terminus of cGMP-dependent protein kinase FlaC_arch PF05377.11 CCF48501.1 - 1.4 9.4 28.5 0.48 10.9 0.5 6.7 6 1 1 7 7 7 0 Flagella accessory protein C (FlaC) Hepatitis_core PF00906.20 CCF48502.1 - 0.073 12.6 1.0 0.47 10.0 0.6 2.1 2 0 0 2 2 2 0 Hepatitis core antigen Homeodomain PF00046.29 CCF48503.1 - 8.3e-16 57.6 2.0 8.3e-16 57.6 2.0 1.8 2 0 0 2 2 2 1 Homeodomain FSH1 PF03959.13 CCF48505.1 - 2.4e-59 200.6 0.0 4.2e-59 199.7 0.0 1.3 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Cyt-b5 PF00173.28 CCF48505.1 - 1.1e-09 38.3 0.6 1.9e-09 37.5 0.6 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Abhydrolase_2 PF02230.16 CCF48505.1 - 0.00044 20.1 0.2 0.0018 18.1 0.1 2.0 2 1 0 2 2 2 1 Phospholipase/Carboxylesterase DUF2048 PF09752.9 CCF48505.1 - 0.033 13.3 0.1 6 5.9 0.0 2.9 2 1 1 3 3 3 0 Abhydrolase domain containing 18 Abhydrolase_1 PF00561.20 CCF48505.1 - 0.051 13.2 0.0 0.76 9.4 0.0 2.2 2 0 0 2 2 2 0 alpha/beta hydrolase fold BAAT_C PF08840.11 CCF48505.1 - 0.13 12.2 0.0 0.31 10.9 0.0 1.5 1 0 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal LAG1-DNAbind PF09271.11 CCF48506.1 - 1.7e-46 158.6 0.7 1.3e-45 155.7 0.0 2.5 2 0 0 2 2 2 1 LAG1, DNA binding BTD PF09270.10 CCF48506.1 - 5e-19 69.0 0.0 1.6e-18 67.4 0.0 1.9 1 1 0 1 1 1 1 Beta-trefoil DNA-binding domain TIG PF01833.24 CCF48506.1 - 0.034 14.2 0.0 0.1 12.7 0.0 1.8 1 0 0 1 1 1 0 IPT/TIG domain PAS_3 PF08447.12 CCF48507.1 - 0.0004 20.6 0.0 0.0011 19.2 0.0 1.8 1 1 0 1 1 1 1 PAS fold Zn_clus PF00172.18 CCF48507.1 - 0.00099 19.2 9.1 0.00099 19.2 9.1 1.9 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PAS PF00989.25 CCF48507.1 - 0.017 15.1 0.0 0.042 13.9 0.0 1.6 1 0 0 1 1 1 0 PAS fold AT_hook PF02178.19 CCF48508.1 - 0.076 12.9 36.5 0.33 11.0 0.9 7.8 6 0 0 6 6 6 0 AT hook motif SPC22 PF04573.12 CCF48509.1 - 5.7e-50 169.1 0.5 6.6e-50 168.9 0.5 1.0 1 0 0 1 1 1 1 Signal peptidase subunit Med11 PF10280.9 CCF48510.1 - 1.6e-10 41.6 1.5 1.8e-10 41.4 0.6 1.6 1 1 0 1 1 1 1 Mediator complex protein SprA-related PF12118.8 CCF48510.1 - 0.011 14.9 2.9 0.02 14.1 2.9 1.4 1 0 0 1 1 1 0 SprA-related family CsgG PF03783.14 CCF48510.1 - 0.056 12.7 4.1 0.056 12.7 2.7 1.6 2 0 0 2 2 2 0 Curli production assembly/transport component CsgG ArfGap PF01412.18 CCF48511.1 - 1.8e-41 140.9 3.2 2.6e-41 140.4 3.2 1.2 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf Abhydrolase_3 PF07859.13 CCF48512.1 - 3.8e-32 111.9 0.0 4.2e-23 82.3 0.0 2.8 2 0 0 2 2 2 2 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 CCF48512.1 - 0.079 11.8 0.0 0.13 11.1 0.0 1.2 1 0 0 1 1 1 0 Steryl acetyl hydrolase FAD_binding_1 PF00667.20 CCF48513.1 - 2.9e-56 190.5 0.0 4.5e-56 189.9 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 CCF48513.1 - 1.5e-34 119.3 0.4 3.1e-34 118.2 0.4 1.6 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.21 CCF48513.1 - 9.8e-22 77.7 0.0 5e-21 75.4 0.0 2.1 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain SQS_PSY PF00494.19 CCF48514.1 - 2.6e-77 259.9 4.7 3.4e-77 259.5 4.7 1.2 1 0 0 1 1 1 1 Squalene/phytoene synthase DUF1765 PF08578.10 CCF48515.1 - 3.7e-27 95.3 1.5 7.6e-27 94.3 1.5 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1765) FtsX PF02687.21 CCF48516.1 - 0.057 13.9 0.1 0.057 13.9 0.1 3.5 2 2 0 2 2 2 0 FtsX-like permease family F5_F8_type_C PF00754.25 CCF48517.1 - 2.4e-07 30.9 0.1 3.2e-07 30.5 0.1 1.2 1 0 0 1 1 1 1 F5/8 type C domain Laminin_N PF00055.17 CCF48517.1 - 0.0019 17.8 0.0 0.0027 17.3 0.0 1.2 1 0 0 1 1 1 1 Laminin N-terminal (Domain VI) RNase_H PF00075.24 CCF48518.1 - 1.2e-36 126.0 0.0 2.3e-36 125.1 0.0 1.5 1 0 0 1 1 1 1 RNase H Cauli_VI PF01693.16 CCF48518.1 - 4.6e-19 68.5 4.4 8.7e-19 67.6 4.4 1.5 1 0 0 1 1 1 1 Caulimovirus viroplasmin Transketolase_N PF00456.21 CCF48518.1 - 0.079 11.9 0.2 0.12 11.3 0.2 1.3 1 0 0 1 1 1 0 Transketolase, thiamine diphosphate binding domain RVT_3 PF13456.6 CCF48518.1 - 0.11 12.3 0.0 0.62 9.9 0.0 2.2 3 0 0 3 3 3 0 Reverse transcriptase-like GPI-anchored PF10342.9 CCF48519.1 - 0.039 14.7 0.1 0.077 13.8 0.1 1.6 1 0 0 1 1 1 0 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family Trm112p PF03966.16 CCF48520.1 - 4e-18 65.7 0.5 8.7e-18 64.7 0.5 1.5 1 1 0 1 1 1 1 Trm112p-like protein zf-NADH-PPase PF09297.11 CCF48520.1 - 0.1 12.3 0.3 0.21 11.3 0.3 1.5 1 0 0 1 1 1 0 NADH pyrophosphatase zinc ribbon domain zinc_ribbon_4 PF13717.6 CCF48520.1 - 0.3 11.1 0.1 0.3 11.1 0.1 2.0 2 0 0 2 2 2 0 zinc-ribbon domain Vps26 PF03643.15 CCF48521.1 - 6.4e-131 435.4 4.4 7.3e-131 435.2 4.4 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 Arrestin_C PF02752.22 CCF48521.1 - 0.0026 18.2 0.4 0.12 12.9 0.1 2.5 2 1 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 CCF48521.1 - 0.0041 17.2 0.8 0.64 10.1 0.1 3.2 2 1 0 3 3 3 1 Arrestin (or S-antigen), N-terminal domain RAP1 PF07218.11 CCF48522.1 - 2.6 6.2 7.7 3.8 5.7 7.7 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) WD40 PF00400.32 CCF48523.1 - 5.1e-12 46.1 6.2 0.0001 23.0 0.1 4.5 5 0 0 5 5 5 3 WD domain, G-beta repeat Arena_nucleocap PF00843.17 CCF48523.1 - 0.048 12.6 0.0 4.4 6.1 0.0 2.2 2 0 0 2 2 2 0 Arenavirus nucleocapsid N-terminal domain Glyco_transf_22 PF03901.17 CCF48524.1 - 9.8e-73 245.7 0.0 1.3e-54 186.0 0.0 2.3 2 1 0 2 2 2 2 Alg9-like mannosyltransferase family Tfb2 PF03849.14 CCF48525.1 - 1.8e-143 477.8 0.0 2.2e-143 477.5 0.0 1.1 1 0 0 1 1 1 1 Transcription factor Tfb2 Tfb2_C PF18307.1 CCF48525.1 - 1.4e-25 89.5 1.2 4.8e-25 87.8 0.7 2.1 2 0 0 2 2 2 1 Transcription factor Tfb2 (p52) C-terminal domain Helicase_C_3 PF13625.6 CCF48525.1 - 0.00066 19.8 0.0 0.0035 17.5 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Diphthamide_syn PF01866.17 CCF48526.1 - 2.2e-84 283.5 0.1 1e-49 169.6 0.0 2.1 2 0 0 2 2 2 2 Putative diphthamide synthesis protein DUF3663 PF12404.8 CCF48526.1 - 0.057 13.5 0.0 0.2 11.7 0.0 1.9 1 0 0 1 1 1 0 Peptidase VIT1 PF01988.19 CCF48527.1 - 6.7e-66 222.2 5.2 1.5e-65 221.1 5.2 1.6 1 1 0 1 1 1 1 VIT family MRC1 PF09444.10 CCF48528.1 - 3e-31 108.9 26.2 3e-31 108.9 26.2 8.6 8 2 0 8 8 8 1 MRC1-like domain Pept_tRNA_hydro PF01195.19 CCF48529.1 - 3e-18 66.4 0.0 2.8e-17 63.2 0.0 2.6 1 1 0 1 1 1 1 Peptidyl-tRNA hydrolase Methyltransf_31 PF13847.6 CCF48529.1 - 1.5e-08 34.6 0.0 2.7e-08 33.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CCF48529.1 - 6.5e-07 29.1 0.0 1.3e-06 28.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.6 CCF48529.1 - 6.8e-05 23.5 0.0 0.00017 22.2 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain N6_Mtase PF02384.16 CCF48529.1 - 0.00012 21.5 0.0 0.00018 20.9 0.0 1.1 1 0 0 1 1 1 1 N-6 DNA Methylase PrmA PF06325.13 CCF48529.1 - 0.00025 20.6 0.1 0.00037 20.0 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Cons_hypoth95 PF03602.15 CCF48529.1 - 0.0096 15.6 0.0 0.02 14.6 0.0 1.4 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_11 PF08241.12 CCF48529.1 - 0.043 14.5 0.0 0.4 11.3 0.0 2.3 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_23 PF13489.6 CCF48529.1 - 0.09 12.6 0.0 0.17 11.7 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_10 PF05971.12 CCF48529.1 - 0.13 11.6 0.0 0.2 11.0 0.0 1.2 1 0 0 1 1 1 0 RNA methyltransferase Aldo_ket_red PF00248.21 CCF48530.1 - 2.4e-61 207.5 0.0 2.9e-61 207.3 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Mito_carr PF00153.27 CCF48532.1 - 3.3e-61 203.2 0.7 8.2e-20 70.5 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Rrp40_N PF18311.1 CCF48533.1 - 1.4e-09 37.7 1.1 3.9e-09 36.3 1.1 1.7 1 0 0 1 1 1 1 Exosome complex exonuclease Rrp40 N-terminal domain KH_6 PF15985.5 CCF48533.1 - 1.3e-08 35.1 0.1 2.3e-08 34.3 0.1 1.4 1 0 0 1 1 1 1 KH domain RAMP4 PF06624.12 CCF48534.1 - 1.5e-05 25.0 11.3 3.9e-05 23.6 5.7 2.4 2 1 0 2 2 2 2 Ribosome associated membrane protein RAMP4 ATG13 PF10033.9 CCF48535.1 - 2.1e-60 204.4 0.0 3.1e-60 203.8 0.0 1.3 1 0 0 1 1 1 1 Autophagy-related protein 13 YedD PF13987.6 CCF48536.1 - 0.058 13.2 0.0 0.14 12.0 0.0 1.7 1 0 0 1 1 1 0 YedD-like protein Pkinase PF00069.25 CCF48537.1 - 6.6e-51 173.2 0.0 1.8e-50 171.8 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF48537.1 - 1e-19 70.8 0.0 2.2e-19 69.8 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 CCF48537.1 - 0.0079 16.1 0.0 0.0079 16.1 0.0 2.4 2 0 0 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.22 CCF48537.1 - 0.016 14.8 0.2 0.039 13.5 0.2 1.6 1 0 0 1 1 1 0 RIO1 family FixO PF02433.15 CCF48537.1 - 5.2 6.5 7.4 17 4.8 7.4 1.8 1 0 0 1 1 1 0 Cytochrome C oxidase, mono-heme subunit/FixO PAC4 PF16093.5 CCF48538.1 - 0.23 11.7 10.1 1.3 9.3 10.1 2.4 1 1 0 1 1 1 0 Proteasome assembly chaperone 4 Ribosomal_S9 PF00380.19 CCF48539.1 - 1.7e-42 144.7 0.1 3e-42 144.0 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein S9/S16 RFX_DNA_binding PF02257.15 CCF48540.1 - 1.8e-23 82.9 0.0 5.1e-23 81.5 0.0 1.8 1 0 0 1 1 1 1 RFX DNA-binding domain Pox_D5 PF03288.16 CCF48540.1 - 0.0058 17.1 0.0 0.012 16.1 0.0 1.4 1 0 0 1 1 1 1 Poxvirus D5 protein-like Pox_RNA_Pol_19 PF05320.12 CCF48541.1 - 8.3 6.4 6.4 20 5.1 6.4 1.6 1 0 0 1 1 1 0 Poxvirus DNA-directed RNA polymerase 19 kDa subunit BPL_LplA_LipB PF03099.19 CCF48542.1 - 4.9e-05 23.2 0.0 0.00011 22.1 0.0 1.6 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family PPR_2 PF13041.6 CCF48542.1 - 0.17 12.1 0.0 0.64 10.3 0.0 2.0 2 0 0 2 2 2 0 PPR repeat family DEAD PF00270.29 CCF48543.1 - 3.6e-41 140.8 0.0 7e-41 139.9 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CCF48543.1 - 2.2e-19 69.9 0.0 7.2e-19 68.2 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CCF48543.1 - 2.9e-05 24.1 0.0 4.8e-05 23.4 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 CCF48543.1 - 0.024 14.9 0.4 0.58 10.4 0.0 2.8 3 0 0 3 3 3 0 AAA domain DUF2075 PF09848.9 CCF48543.1 - 0.056 12.7 0.0 0.083 12.1 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) DUF4106 PF13388.6 CCF48544.1 - 0.03 13.6 1.9 0.037 13.3 1.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4106) GWT1 PF06423.12 CCF48545.1 - 2e-38 131.9 0.1 5.8e-38 130.4 0.1 1.8 1 0 0 1 1 1 1 GWT1 FAM176 PF14851.6 CCF48545.1 - 0.05 13.3 0.2 0.05 13.3 0.2 1.8 2 0 0 2 2 2 0 FAM176 family FA_desaturase PF00487.24 CCF48545.1 - 0.24 11.2 11.8 0.62 9.8 3.1 2.7 2 0 0 2 2 2 0 Fatty acid desaturase Exo_endo_phos PF03372.23 CCF48546.1 - 4.2e-09 36.3 0.0 6.4e-09 35.7 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family IF-2B PF01008.17 CCF48548.1 - 3.8e-69 233.0 0.0 4.7e-69 232.7 0.0 1.1 1 0 0 1 1 1 1 Initiation factor 2 subunit family TFIID_20kDa PF03847.13 CCF48548.1 - 0.092 13.3 0.3 0.19 12.2 0.3 1.5 1 0 0 1 1 1 0 Transcription initiation factor TFIID subunit A Pkinase PF00069.25 CCF48549.1 - 4.1e-30 105.0 0.0 9.7e-25 87.4 0.0 3.5 3 1 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.17 CCF48549.1 - 2.1e-17 63.3 0.0 1.2e-14 54.3 0.0 2.4 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 CCF48549.1 - 6e-05 22.5 0.0 0.0001 21.7 0.0 1.3 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.22 CCF48549.1 - 0.072 12.7 0.0 0.12 12.0 0.0 1.2 1 0 0 1 1 1 0 RIO1 family PI3_PI4_kinase PF00454.27 CCF48550.1 - 2.7e-33 115.8 0.0 7.3e-33 114.4 0.0 1.7 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase CAP_GLY PF01302.25 CCF48551.1 - 3.7e-16 58.9 0.1 6.7e-16 58.1 0.1 1.4 1 0 0 1 1 1 1 CAP-Gly domain zf-CCHC_4 PF14392.6 CCF48551.1 - 0.11 12.2 4.0 5.5 6.8 0.3 2.4 2 0 0 2 2 2 0 Zinc knuckle Pkinase PF00069.25 CCF48552.1 - 5.1e-49 167.0 0.0 4.7e-48 163.9 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF48552.1 - 3e-29 102.1 0.0 7.7e-23 81.1 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase APH PF01636.23 CCF48552.1 - 0.017 15.0 0.2 0.56 10.1 0.0 2.4 1 1 1 2 2 2 0 Phosphotransferase enzyme family Cellulase PF00150.18 CCF48553.1 - 0.00019 21.0 0.2 0.076 12.4 0.1 2.2 2 0 0 2 2 2 2 Cellulase (glycosyl hydrolase family 5) Acyl_transf_3 PF01757.22 CCF48555.1 - 7.5e-37 127.2 26.8 7.5e-37 127.2 26.8 3.0 3 0 0 3 3 3 1 Acyltransferase family Glyco_trans_2_3 PF13632.6 CCF48555.1 - 5.6e-30 104.7 1.7 5.6e-30 104.7 1.7 3.6 4 0 0 4 4 4 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 CCF48555.1 - 4.8e-13 49.5 0.0 7.5e-13 48.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 CCF48555.1 - 0.072 12.6 0.4 0.94 8.9 0.1 2.7 2 1 0 2 2 2 0 Glycosyl transferase family 21 FAD_binding_3 PF01494.19 CCF48556.1 - 7.6e-20 71.5 0.1 7.4e-13 48.5 0.0 3.0 2 2 0 2 2 2 2 FAD binding domain Pyr_redox_2 PF07992.14 CCF48556.1 - 1.9e-06 27.3 0.2 5.2e-06 25.9 0.1 1.7 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CCF48556.1 - 1.1e-05 25.8 0.3 9.9e-05 22.8 0.0 2.8 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CCF48556.1 - 5.4e-05 23.4 0.1 0.00025 21.2 0.0 2.2 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CCF48556.1 - 0.00017 21.3 0.0 0.00039 20.1 0.0 1.6 1 0 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.14 CCF48556.1 - 0.00066 18.5 1.0 0.0026 16.5 0.0 2.5 2 0 0 2 2 2 1 HI0933-like protein GIDA PF01134.22 CCF48556.1 - 0.0025 17.0 0.0 0.005 16.0 0.0 1.5 1 0 0 1 1 1 1 Glucose inhibited division protein A 3HCDH_N PF02737.18 CCF48556.1 - 0.0027 17.6 0.1 0.014 15.3 0.0 2.3 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain SE PF08491.10 CCF48556.1 - 0.013 14.6 0.1 0.34 9.9 0.0 2.8 3 0 0 3 3 3 0 Squalene epoxidase DNA_ligase_A_N PF04675.14 CCF48556.1 - 0.039 14.3 0.8 0.11 12.8 0.8 1.7 1 0 0 1 1 1 0 DNA ligase N terminus Spc7 PF08317.11 CCF48556.1 - 0.053 12.4 3.2 0.11 11.4 3.2 1.4 1 0 0 1 1 1 0 Spc7 kinetochore protein UDPG_MGDP_dh_N PF03721.14 CCF48556.1 - 0.068 12.7 0.0 1.3 8.6 0.0 2.7 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain FAD_binding_2 PF00890.24 CCF48556.1 - 0.1 11.6 0.0 0.22 10.5 0.0 1.6 1 0 0 1 1 1 0 FAD binding domain ApbA PF02558.16 CCF48556.1 - 0.13 11.9 0.0 0.31 10.7 0.0 1.7 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA DUF1664 PF07889.12 CCF48556.1 - 0.99 9.5 3.1 2.4 8.2 3.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Glyco_hydro_45 PF02015.16 CCF48558.1 - 2e-103 344.8 12.9 3.4e-103 344.1 12.9 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 45 RNA_pol_Rpc34 PF05158.12 CCF48559.1 - 1.7e-76 257.8 7.3 1.3e-68 231.9 0.6 2.6 1 1 0 3 3 3 2 RNA polymerase Rpc34 subunit TrmB PF01978.19 CCF48559.1 - 0.022 14.6 0.1 0.073 13.0 0.1 1.9 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB B-block_TFIIIC PF04182.12 CCF48559.1 - 0.035 14.3 0.9 0.084 13.0 0.3 2.0 2 0 0 2 2 2 0 B-block binding subunit of TFIIIC SOG2 PF10428.9 CCF48559.1 - 1.6 7.8 26.9 3.2 6.8 26.9 1.5 1 0 0 1 1 1 0 RAM signalling pathway protein Peptidase_M20 PF01546.28 CCF48560.1 - 7.5e-25 87.9 0.0 1.2e-24 87.1 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 WD40 PF00400.32 CCF48560.1 - 1e-18 67.3 16.5 1.9e-05 25.3 0.0 6.8 7 0 0 7 7 7 5 WD domain, G-beta repeat M20_dimer PF07687.14 CCF48560.1 - 1.9e-09 37.4 0.0 3.8e-09 36.4 0.0 1.5 1 0 0 1 1 1 1 Peptidase dimerisation domain Nucleoporin_N PF08801.11 CCF48560.1 - 0.004 16.0 1.3 0.14 10.9 0.3 3.4 3 2 1 4 4 4 1 Nup133 N terminal like Pox_TAP PF03355.14 CCF48560.1 - 0.11 12.0 0.0 0.21 11.1 0.0 1.3 1 0 0 1 1 1 0 Viral Trans-Activator Protein Glyoxalase PF00903.25 CCF48561.1 - 4.7e-23 81.8 0.3 6.5e-23 81.3 0.3 1.2 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 CCF48561.1 - 2.8e-08 34.0 0.0 4.6e-08 33.3 0.0 1.4 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_2 PF12681.7 CCF48561.1 - 4.5e-06 26.6 1.0 7.1e-05 22.7 1.0 2.3 1 1 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_6 PF18029.1 CCF48561.1 - 5e-06 27.3 0.0 6.8e-06 26.8 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_3 PF13468.6 CCF48561.1 - 6.9e-06 26.3 0.0 0.011 15.8 0.0 2.1 1 1 1 2 2 2 2 Glyoxalase-like domain DUF1681 PF07933.14 CCF48561.1 - 0.081 12.6 0.1 0.13 12.0 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1681) Glycos_transf_2 PF00535.26 CCF48562.1 - 2.7e-29 102.1 0.0 3.5e-29 101.8 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 CCF48562.1 - 7.7e-08 32.5 0.0 1.2e-07 31.9 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 CCF48562.1 - 0.14 11.6 0.0 0.2 11.1 0.0 1.2 1 0 0 1 1 1 0 Glycosyltransferase like family 2 CLASP_N PF12348.8 CCF48563.1 - 1.3e-23 83.8 0.0 2.5e-07 30.5 0.0 5.3 4 1 1 5 5 5 4 CLASP N terminal HEAT PF02985.22 CCF48563.1 - 3e-15 55.0 18.5 0.024 14.9 0.0 9.0 9 0 0 9 9 9 4 HEAT repeat Cnd1 PF12717.7 CCF48563.1 - 4.5e-12 46.3 4.7 0.56 10.2 0.0 7.0 6 1 1 7 7 7 3 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 CCF48563.1 - 1.6e-07 31.6 13.1 0.23 11.8 0.0 7.3 6 2 2 8 8 8 2 HEAT repeats Vac14_Fab1_bd PF12755.7 CCF48563.1 - 0.0015 19.1 0.0 4.7 7.9 0.0 5.5 5 1 1 6 6 6 1 Vacuolar 14 Fab1-binding region Proteasom_PSMB PF10508.9 CCF48563.1 - 0.011 14.2 0.1 1.4 7.3 0.1 2.5 2 0 0 2 2 2 0 Proteasome non-ATPase 26S subunit IFRD PF05004.13 CCF48563.1 - 0.028 13.5 1.2 16 4.4 0.0 4.7 5 0 0 5 5 5 0 Interferon-related developmental regulator (IFRD) MMS19_N PF14500.6 CCF48563.1 - 0.035 13.7 0.1 12 5.4 0.1 4.3 3 1 1 4 4 4 0 Dos2-interacting transcription regulator of RNA-Pol-II TIP120 PF08623.10 CCF48563.1 - 0.13 12.0 0.5 18 5.0 0.0 3.7 2 1 1 3 3 3 0 TATA-binding protein interacting (TIP20) Arm PF00514.23 CCF48563.1 - 0.21 11.7 7.4 0.8 9.8 0.1 4.9 5 0 0 5 5 4 0 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 CCF48563.1 - 8.3 7.0 22.9 2.8 8.5 0.0 7.2 7 0 0 7 7 6 0 HEAT-like repeat NUDE_C PF04880.13 CCF48564.1 - 7.2e-14 52.6 10.5 7.2e-14 52.6 10.5 6.3 2 2 2 7 7 4 1 NUDE protein, C-terminal conserved region DUF2353 PF09789.9 CCF48564.1 - 8.7e-05 22.0 24.5 0.00037 20.0 12.6 2.2 1 1 1 2 2 2 2 Uncharacterized coiled-coil protein (DUF2353) HIP1_clath_bdg PF16515.5 CCF48564.1 - 0.00025 21.6 6.4 0.00025 21.6 6.4 3.5 1 1 2 3 3 3 1 Clathrin-binding domain of Huntingtin-interacting protein 1 Phage_GP20 PF06810.11 CCF48564.1 - 0.00057 19.7 6.5 0.00057 19.7 6.5 3.3 1 1 3 4 4 4 1 Phage minor structural protein GP20 ATG16 PF08614.11 CCF48564.1 - 0.0018 18.5 15.3 0.0018 18.5 15.3 3.9 2 1 1 3 3 3 2 Autophagy protein 16 (ATG16) DHR10 PF18595.1 CCF48564.1 - 0.0019 18.2 9.4 0.0019 18.2 9.4 3.5 2 1 0 3 3 3 1 Designed helical repeat protein 10 domain TPR_MLP1_2 PF07926.12 CCF48564.1 - 0.0023 18.0 30.1 0.0035 17.4 6.2 3.8 1 1 2 3 3 3 1 TPR/MLP1/MLP2-like protein Filament PF00038.21 CCF48564.1 - 0.0023 17.6 8.7 0.0023 17.6 8.7 2.4 1 1 1 2 2 2 1 Intermediate filament protein CENP-F_leu_zip PF10473.9 CCF48564.1 - 0.003 17.6 10.6 0.003 17.6 10.6 2.5 3 0 0 3 3 2 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 PRKG1_interact PF15898.5 CCF48564.1 - 0.017 16.0 26.7 0.092 13.7 13.7 3.1 2 1 0 2 2 2 0 cGMP-dependent protein kinase interacting domain DUF3584 PF12128.8 CCF48564.1 - 0.018 12.6 20.5 0.025 12.1 20.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) HOOK PF05622.12 CCF48564.1 - 0.026 12.7 24.8 0.062 11.4 24.9 1.4 1 1 0 1 1 1 0 HOOK protein ERM PF00769.19 CCF48564.1 - 0.029 14.2 31.5 0.34 10.7 10.4 2.3 1 1 1 2 2 2 0 Ezrin/radixin/moesin family Prefoldin_2 PF01920.20 CCF48564.1 - 0.031 14.2 23.9 5.5 7.0 14.0 4.3 2 1 2 4 4 4 0 Prefoldin subunit HTH_Tnp_1 PF01527.20 CCF48564.1 - 0.034 14.5 0.5 0.034 14.5 0.5 3.3 2 1 0 2 2 2 0 Transposase Latarcin PF10279.9 CCF48564.1 - 0.054 13.9 7.5 1.3 9.5 1.1 3.6 1 1 1 2 2 2 0 Latarcin precursor TACC_C PF05010.14 CCF48564.1 - 0.12 12.2 22.0 0.75 9.5 21.7 2.1 1 1 1 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal Syntaxin-6_N PF09177.11 CCF48564.1 - 0.13 12.8 23.1 0.16 12.5 6.9 3.9 1 1 2 3 3 3 0 Syntaxin 6, N-terminal Fez1 PF06818.15 CCF48564.1 - 0.4 11.1 26.2 0.62 10.5 13.8 2.4 1 1 1 2 2 2 0 Fez1 ZapB PF06005.12 CCF48564.1 - 0.44 11.0 30.4 0.083 13.3 8.9 4.2 2 1 2 4 4 4 0 Cell division protein ZapB Mating_N PF12731.7 CCF48564.1 - 0.6 10.2 5.1 0.82 9.8 0.4 2.9 1 1 1 2 2 2 0 Mating-type protein beta 1 Phlebovirus_NSM PF07246.11 CCF48564.1 - 0.61 9.4 10.8 1.4 8.3 2.8 2.4 1 1 1 2 2 2 0 Phlebovirus nonstructural protein NS-M YscO PF07321.12 CCF48564.1 - 0.74 9.8 18.5 0.36 10.8 6.5 2.6 1 1 1 2 2 2 0 Type III secretion protein YscO Baculo_PEP_C PF04513.12 CCF48564.1 - 0.97 9.5 5.3 0.78 9.8 0.6 2.3 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus SlyX PF04102.12 CCF48564.1 - 1.1 10.0 15.6 1.4 9.6 1.2 4.8 3 1 2 5 5 5 0 SlyX UPF0242 PF06785.11 CCF48564.1 - 1.2 9.2 26.2 0.08 13.0 12.8 2.4 1 1 2 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus DMPK_coil PF08826.10 CCF48564.1 - 1.2 9.3 22.6 0.24 11.6 2.0 3.7 3 0 0 3 3 3 0 DMPK coiled coil domain like Bacillus_HBL PF05791.11 CCF48564.1 - 1.3 8.8 8.2 0.11 12.4 3.2 1.7 2 0 0 2 2 1 0 Bacillus haemolytic enterotoxin (HBL) DUF5094 PF17015.5 CCF48564.1 - 1.5 8.9 20.5 0.38 10.8 6.1 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF5094) Rab5-bind PF09311.11 CCF48564.1 - 1.5 8.1 24.0 32 3.8 23.5 2.1 1 1 0 1 1 1 0 Rabaptin-like protein BLOC1_2 PF10046.9 CCF48564.1 - 1.7 9.0 19.8 0.63 10.4 3.5 3.5 2 1 2 4 4 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DivIC PF04977.15 CCF48564.1 - 1.7 8.4 17.0 0.55 10.0 0.3 3.8 3 1 1 4 4 3 0 Septum formation initiator NPV_P10 PF05531.12 CCF48564.1 - 1.8 9.1 7.0 58 4.3 3.7 3.2 1 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Golgin_A5 PF09787.9 CCF48564.1 - 2.4 7.5 26.4 0.42 10.0 12.5 2.3 1 1 1 2 2 2 0 Golgin subfamily A member 5 CCDC-167 PF15188.6 CCF48564.1 - 3.3 8.1 24.2 12 6.3 2.9 2.8 2 1 0 2 2 2 0 Coiled-coil domain-containing protein 167 Spc7 PF08317.11 CCF48564.1 - 3.4 6.5 29.0 3.3 6.5 17.7 2.7 2 1 1 3 3 3 0 Spc7 kinetochore protein WXG100 PF06013.12 CCF48564.1 - 4.4 7.6 10.0 15 5.9 0.2 4.0 3 1 1 4 4 3 0 Proteins of 100 residues with WXG COMP PF11598.8 CCF48564.1 - 5.1 7.7 7.3 0.46 11.0 1.3 2.3 3 0 0 3 3 1 0 Cartilage oligomeric matrix protein HALZ PF02183.18 CCF48564.1 - 5.6 7.3 9.1 0.76 10.1 1.3 2.8 2 1 0 2 2 2 0 Homeobox associated leucine zipper Atg14 PF10186.9 CCF48564.1 - 6.1 5.8 19.2 0.61 9.1 10.2 2.3 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 CENP-K PF11802.8 CCF48564.1 - 7.9 6.0 19.5 13 5.3 19.5 1.3 1 0 0 1 1 1 0 Centromere-associated protein K Fib_alpha PF08702.10 CCF48564.1 - 9.7 6.4 19.5 0.23 11.6 5.2 2.7 2 1 1 3 3 2 0 Fibrinogen alpha/beta chain family FAA_hydrolase PF01557.18 CCF48565.1 - 2.8e-50 171.0 0.0 3.6e-50 170.6 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family GST_N PF02798.20 CCF48566.1 - 4.3e-11 43.0 0.0 9e-11 42.0 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 CCF48566.1 - 1.1e-10 41.8 0.0 1.9e-10 41.0 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 CCF48566.1 - 5.4e-10 39.4 0.0 9.4e-10 38.6 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 CCF48566.1 - 2.1e-09 37.5 0.0 4.2e-09 36.6 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 CCF48566.1 - 1.3e-07 31.5 0.0 2.1e-07 30.9 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 CCF48566.1 - 5.3e-06 26.5 0.0 1.5e-05 25.1 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain OSCP PF00213.18 CCF48567.1 - 5.4e-37 127.6 0.2 6.3e-37 127.3 0.2 1.0 1 0 0 1 1 1 1 ATP synthase delta (OSCP) subunit Strep_SA_rep PF06696.11 CCF48567.1 - 0.043 13.8 0.1 0.16 12.0 0.1 2.0 1 0 0 1 1 1 0 Streptococcal surface antigen repeat RRF PF01765.19 CCF48567.1 - 0.079 12.9 0.1 1.2 9.1 0.0 2.3 1 1 1 2 2 2 0 Ribosome recycling factor eIF-3c_N PF05470.12 CCF48568.1 - 2.3e-180 600.9 17.7 2.3e-180 600.9 17.7 2.3 1 1 1 2 2 2 1 Eukaryotic translation initiation factor 3 subunit 8 N-terminus PCI PF01399.27 CCF48568.1 - 5.5e-13 49.3 0.0 1.9e-12 47.6 0.0 2.0 1 0 0 1 1 1 1 PCI domain DUF1289 PF06945.13 CCF48568.1 - 0.079 12.8 0.2 0.21 11.5 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1289) FeoC PF09012.10 CCF48568.1 - 0.1 12.7 0.7 0.38 10.8 0.0 2.3 2 0 0 2 2 2 0 FeoC like transcriptional regulator DUF2779 PF11074.8 CCF48568.1 - 0.3 11.5 6.0 8.9 6.8 0.1 3.7 3 1 1 4 4 4 0 Domain of unknown function(DUF2779) CDC45 PF02724.14 CCF48568.1 - 0.4 8.9 18.4 0.86 7.8 18.4 1.5 1 0 0 1 1 1 0 CDC45-like protein Mt_ATP-synt_B PF05405.14 CCF48568.1 - 1.2 8.8 7.7 6.8 6.3 0.7 3.7 3 0 0 3 3 3 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) DUF4363 PF14276.6 CCF48568.1 - 3 8.0 7.3 6 7.0 1.2 4.0 2 2 0 3 3 3 0 Domain of unknown function (DUF4363) DnaJ PF00226.31 CCF48569.1 - 6.3e-11 42.3 0.6 6.3e-11 42.3 0.6 2.0 2 0 0 2 2 2 1 DnaJ domain Pkinase PF00069.25 CCF48570.1 - 2.4e-08 33.7 0.0 4.5e-08 32.8 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain HEAT PF02985.22 CCF48570.1 - 5e-05 23.2 2.5 0.49 10.8 0.0 5.6 5 0 0 5 5 5 1 HEAT repeat Cnd1 PF12717.7 CCF48570.1 - 0.0043 17.1 0.1 0.048 13.7 0.0 2.2 1 1 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 Pkinase_Tyr PF07714.17 CCF48570.1 - 0.1 11.8 0.0 0.17 11.1 0.0 1.3 1 0 0 1 1 1 0 Protein tyrosine kinase Vac14_Fab1_bd PF12755.7 CCF48570.1 - 0.2 12.3 0.0 10 6.8 0.0 2.8 2 1 1 3 3 3 0 Vacuolar 14 Fab1-binding region Med14 PF08638.11 CCF48571.1 - 2.3e-54 183.7 0.1 5.2e-54 182.6 0.1 1.6 1 0 0 1 1 1 1 Mediator complex subunit MED14 MHYT PF03707.16 CCF48572.1 - 4.7e-16 58.7 17.5 5.2e-06 26.5 4.3 4.6 4 0 0 4 4 4 4 Bacterial signalling protein N terminal repeat LPAM_1 PF08139.12 CCF48572.1 - 0.26 11.8 1.5 0.45 11.1 0.1 2.2 2 0 0 2 2 2 0 Prokaryotic membrane lipoprotein lipid attachment site MSA-2c PF12238.8 CCF48572.1 - 5.7 6.9 7.2 13 5.7 7.2 1.5 1 0 0 1 1 1 0 Merozoite surface antigen 2c Pex16 PF08610.10 CCF48574.1 - 1.3e-121 405.7 0.0 1.7e-121 405.3 0.0 1.2 1 0 0 1 1 1 1 Peroxisomal membrane protein (Pex16) Pkinase PF00069.25 CCF48575.1 - 1.6e-59 201.5 0.0 2e-59 201.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF48575.1 - 2.4e-38 131.9 0.0 3.1e-38 131.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCF48575.1 - 0.0001 21.7 0.0 0.00018 20.9 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 CCF48575.1 - 0.02 13.9 0.0 0.036 13.0 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain Pkinase_fungal PF17667.1 CCF48575.1 - 0.045 12.5 0.0 0.07 11.9 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase APH PF01636.23 CCF48575.1 - 0.083 12.8 0.0 0.57 10.1 0.0 2.2 2 1 1 3 3 3 0 Phosphotransferase enzyme family Sporozoite_P67 PF05642.11 CCF48575.1 - 5.3 5.0 11.9 9.5 4.2 11.9 1.4 1 0 0 1 1 1 0 Sporozoite P67 surface antigen MmgE_PrpD PF03972.14 CCF48576.1 - 1.6e-149 498.2 0.0 2e-149 497.9 0.0 1.1 1 0 0 1 1 1 1 MmgE/PrpD family PALP PF00291.25 CCF48577.1 - 5.8e-69 232.7 0.0 7.5e-69 232.4 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme DUF3425 PF11905.8 CCF48578.1 - 1.1e-08 35.1 0.1 2.4e-08 34.0 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3425) bZIP_2 PF07716.15 CCF48578.1 - 0.042 13.9 2.4 0.073 13.2 2.4 1.3 1 0 0 1 1 1 0 Basic region leucine zipper PPR_3 PF13812.6 CCF48580.1 - 1.4e-16 60.3 0.4 7.5e-09 35.5 0.0 5.6 5 1 1 6 6 6 3 Pentatricopeptide repeat domain PPR_2 PF13041.6 CCF48580.1 - 4e-14 52.5 0.2 5.7e-06 26.4 0.0 5.3 5 1 1 6 6 6 2 PPR repeat family PPR PF01535.20 CCF48580.1 - 4.4e-07 29.7 0.1 2.7 8.4 0.0 5.9 7 0 0 7 7 7 2 PPR repeat PPR_long PF17177.4 CCF48580.1 - 4.7e-06 26.1 0.0 0.001 18.5 0.0 2.9 2 1 0 2 2 2 2 Pentacotripeptide-repeat region of PRORP PPR_1 PF12854.7 CCF48580.1 - 0.018 14.7 0.1 0.46 10.2 0.1 3.0 3 0 0 3 3 3 0 PPR repeat KH_1 PF00013.29 CCF48581.1 - 5.5e-90 295.2 34.4 4.6e-13 48.8 2.3 15.2 16 1 0 16 16 16 12 KH domain KH_2 PF07650.17 CCF48581.1 - 3.4e-18 65.2 24.6 0.013 15.3 1.0 10.3 10 1 1 11 11 11 5 KH domain KH_4 PF13083.6 CCF48581.1 - 2.9e-08 33.4 21.7 0.2 11.5 0.0 8.7 7 1 2 9 9 9 6 KH domain SLS PF14611.6 CCF48581.1 - 9.5e-08 32.1 20.4 0.0011 18.8 0.4 7.7 6 3 1 7 7 7 2 Mitochondrial inner-membrane-bound regulator KH_5 PF13184.6 CCF48581.1 - 0.0049 16.9 3.9 3.7 7.7 0.0 5.4 5 0 0 5 5 5 2 NusA-like KH domain DUF4112 PF13430.6 CCF48582.1 - 2.7e-31 107.9 1.5 7.4e-31 106.5 1.5 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4112) MFS_1 PF07690.16 CCF48582.1 - 1.5e-19 70.2 44.2 7.3e-14 51.4 24.3 2.8 2 1 1 3 3 3 2 Major Facilitator Superfamily OATP PF03137.20 CCF48582.1 - 0.0007 18.0 8.1 0.03 12.6 0.0 2.4 1 1 1 2 2 2 2 Organic Anion Transporter Polypeptide (OATP) family RT_RNaseH PF17917.1 CCF48585.1 - 0.11 12.8 0.0 0.21 11.9 0.0 1.4 1 0 0 1 1 1 0 RNase H-like domain found in reverse transcriptase KAR9 PF08580.10 CCF48586.1 - 8.3e-19 67.6 17.1 8.3e-19 67.6 17.1 4.3 3 1 1 4 4 4 1 Yeast cortical protein KAR9 GAS2 PF02187.17 CCF48586.1 - 0.00049 20.1 0.3 0.0015 18.5 0.2 1.8 2 0 0 2 2 2 1 Growth-Arrest-Specific Protein 2 Domain PilJ PF13675.6 CCF48586.1 - 0.0064 16.5 2.0 4 7.5 0.0 3.6 4 0 0 4 4 4 2 Type IV pili methyl-accepting chemotaxis transducer N-term Rootletin PF15035.6 CCF48586.1 - 0.099 12.7 1.9 1 9.4 0.2 2.4 2 0 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion Spectrin PF00435.21 CCF48586.1 - 0.26 11.8 4.3 6.3 7.3 0.1 3.3 3 0 0 3 3 3 0 Spectrin repeat Cnn_1N PF07989.11 CCF48586.1 - 0.35 11.0 4.0 11 6.2 0.0 2.9 3 0 0 3 3 3 0 Centrosomin N-terminal motif 1 Cep57_CLD_2 PF14197.6 CCF48586.1 - 1.1 9.3 11.2 12 6.1 0.2 4.0 3 0 0 3 3 3 0 Centrosome localisation domain of PPC89 HalX PF08663.10 CCF48586.1 - 3.2 8.1 7.8 0.35 11.2 0.2 2.9 3 0 0 3 3 3 0 HalX domain Ribosomal_L27 PF01016.19 CCF48587.1 - 5.6e-31 106.4 0.1 8.6e-31 105.8 0.1 1.3 1 0 0 1 1 1 1 Ribosomal L27 protein OEP PF02321.18 CCF48587.1 - 0.16 11.8 0.5 0.24 11.2 0.0 1.5 2 0 0 2 2 2 0 Outer membrane efflux protein Tim17 PF02466.19 CCF48588.1 - 1.6e-22 80.0 7.5 2.4e-22 79.4 7.5 1.2 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family Fungal_trans PF04082.18 CCF48589.1 - 1.2e-12 47.5 0.0 2e-12 46.7 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF48589.1 - 0.0002 21.4 11.1 0.00037 20.5 11.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Use1 PF09753.9 CCF48589.1 - 2.8 7.6 4.9 2.9 7.6 3.3 1.8 2 0 0 2 2 2 0 Membrane fusion protein Use1 PHF5 PF03660.14 CCF48590.1 - 1.6e-49 166.4 6.3 1.9e-49 166.2 6.3 1.0 1 0 0 1 1 1 1 PHF5-like protein C1_2 PF03107.16 CCF48590.1 - 0.051 13.9 12.7 0.65 10.4 2.7 2.4 1 1 1 2 2 2 0 C1 domain PolC_DP2 PF03833.13 CCF48590.1 - 0.093 10.6 3.6 0.097 10.5 3.6 1.0 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 DZR PF12773.7 CCF48590.1 - 0.26 11.3 9.8 1.5 8.9 1.1 2.4 1 1 1 2 2 2 0 Double zinc ribbon RecR PF02132.15 CCF48590.1 - 1.2 8.7 13.6 0.81 9.3 1.1 3.2 3 0 0 3 3 3 0 RecR protein zf-C3HC4_3 PF13920.6 CCF48590.1 - 2.1 8.3 13.1 3.3 7.6 5.0 3.2 2 1 1 3 3 3 0 Zinc finger, C3HC4 type (RING finger) TF_Zn_Ribbon PF08271.12 CCF48590.1 - 2.2 7.9 13.0 0.54 9.8 2.0 2.6 2 1 0 2 2 2 0 TFIIB zinc-binding zf-C6H2 PF15801.5 CCF48590.1 - 2.7 8.4 8.0 2.2 8.7 2.0 2.7 2 1 1 3 3 3 0 zf-MYND-like zinc finger, mRNA-binding DUF2039 PF10217.9 CCF48590.1 - 4.7 7.6 9.5 0.91 9.9 1.4 2.3 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2039) Prok-RING_1 PF14446.6 CCF48590.1 - 7.2 6.6 11.6 1.7 8.6 2.2 2.5 1 1 1 2 2 2 0 Prokaryotic RING finger family 1 PH_12 PF16457.5 CCF48591.1 - 9e-35 120.1 0.0 2e-34 119.0 0.0 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain ELMO_CED12 PF04727.13 CCF48591.1 - 1e-27 97.4 0.0 1.5e-27 96.8 0.0 1.3 1 0 0 1 1 1 1 ELMO/CED-12 family DUF3361 PF11841.8 CCF48591.1 - 6.3e-21 74.9 0.0 3.3e-20 72.6 0.0 2.2 2 1 0 2 2 2 1 Domain of unknown function (DUF3361) V-ATPase_H_N PF03224.14 CCF48591.1 - 0.061 12.6 0.2 0.64 9.3 0.0 2.1 2 0 0 2 2 2 0 V-ATPase subunit H Arm PF00514.23 CCF48591.1 - 0.16 12.1 1.4 25 5.1 0.2 3.7 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat Coq4 PF05019.13 CCF48592.1 - 1.7e-61 207.4 0.0 3.5e-50 170.4 0.0 2.1 1 1 1 2 2 2 2 Coenzyme Q (ubiquinone) biosynthesis protein Coq4 Glyco_transf_21 PF13506.6 CCF48593.1 - 3.1e-21 75.6 0.3 4.1e-08 32.9 0.0 3.4 3 0 0 3 3 3 3 Glycosyl transferase family 21 Glyco_tranf_2_3 PF13641.6 CCF48593.1 - 3.3e-08 33.7 0.8 1.9e-07 31.2 0.1 2.2 2 1 0 2 2 2 1 Glycosyltransferase like family 2 VIT_2 PF13757.6 CCF48593.1 - 0.19 11.7 0.2 1.1 9.2 0.0 2.2 2 0 0 2 2 2 0 Vault protein inter-alpha-trypsin domain Dscam_C PF12355.8 CCF48593.1 - 1.4 9.9 4.5 4.1 8.4 0.4 2.4 2 0 0 2 2 2 0 Down syndrome cell adhesion molecule C terminal Lyase_1 PF00206.20 CCF48594.1 - 1.1e-95 320.6 0.0 1.9e-95 319.9 0.0 1.3 1 0 0 1 1 1 1 Lyase ASL_C2 PF14698.6 CCF48594.1 - 1.3e-24 86.7 0.0 2.9e-24 85.6 0.0 1.6 1 0 0 1 1 1 1 Argininosuccinate lyase C-terminal Pinin_SDK_N PF04697.13 CCF48596.1 - 0.9 10.2 8.9 2.3 8.9 0.7 4.2 3 0 0 3 3 3 0 pinin/SDK conserved region Methyltransf_31 PF13847.6 CCF48597.1 - 8e-27 93.9 0.0 3.6e-25 88.5 0.0 2.7 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF48597.1 - 2e-22 79.7 0.0 4e-22 78.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF48597.1 - 6.6e-22 78.0 0.1 4.8e-21 75.3 0.0 2.3 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCF48597.1 - 3.9e-17 62.6 0.0 6e-17 62.0 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF48597.1 - 5.2e-16 59.2 0.0 9.9e-16 58.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CCF48597.1 - 5.8e-13 48.7 0.0 1e-12 47.9 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.14 CCF48597.1 - 2e-08 34.0 0.0 3.9e-08 33.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain PCMT PF01135.19 CCF48597.1 - 1e-06 28.7 0.0 1.4e-06 28.2 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_4 PF02390.17 CCF48597.1 - 4.3e-06 26.3 0.0 1.1e-05 25.0 0.0 1.7 1 1 0 1 1 1 1 Putative methyltransferase MetW PF07021.12 CCF48597.1 - 0.00043 19.9 0.0 0.008 15.8 0.0 2.1 1 1 0 1 1 1 1 Methionine biosynthesis protein MetW CMAS PF02353.20 CCF48597.1 - 0.00065 19.1 0.0 0.001 18.4 0.0 1.3 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase DREV PF05219.12 CCF48597.1 - 0.00086 18.5 0.0 0.0058 15.8 0.0 1.9 1 1 0 1 1 1 1 DREV methyltransferase Methyltransf_32 PF13679.6 CCF48597.1 - 0.0011 19.0 0.0 0.0018 18.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_9 PF08003.11 CCF48597.1 - 0.0012 17.9 0.0 0.0029 16.6 0.0 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF1698) CheR PF01739.18 CCF48597.1 - 0.0075 15.8 0.0 2.1 7.8 0.0 2.2 2 0 0 2 2 2 1 CheR methyltransferase, SAM binding domain Methyltransf_29 PF03141.16 CCF48597.1 - 0.0083 14.7 1.8 0.0098 14.5 0.0 1.9 2 1 0 2 2 2 1 Putative S-adenosyl-L-methionine-dependent methyltransferase FtsJ PF01728.19 CCF48597.1 - 0.0087 16.2 0.0 0.012 15.7 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_8 PF05148.15 CCF48597.1 - 0.009 15.9 0.0 0.22 11.4 0.0 2.1 2 0 0 2 2 2 1 Hypothetical methyltransferase NodS PF05401.11 CCF48597.1 - 0.022 14.4 0.0 0.048 13.3 0.0 1.6 1 1 0 1 1 1 0 Nodulation protein S (NodS) Methyltr_RsmB-F PF01189.17 CCF48597.1 - 0.055 13.1 0.0 0.089 12.4 0.0 1.3 1 0 0 1 1 1 0 16S rRNA methyltransferase RsmB/F RrnaAD PF00398.20 CCF48597.1 - 0.084 11.9 0.1 0.18 10.8 0.0 1.5 2 0 0 2 2 2 0 Ribosomal RNA adenine dimethylase Methyltransf_18 PF12847.7 CCF48597.1 - 0.19 11.6 0.0 0.36 10.8 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain DUF1772 PF08592.11 CCF48598.1 - 6.3e-24 84.9 3.3 7.8e-24 84.5 3.3 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1772) FMN_dh PF01070.18 CCF48602.1 - 1.5e-105 353.1 0.0 1.8e-105 352.8 0.0 1.0 1 0 0 1 1 1 1 FMN-dependent dehydrogenase IMPDH PF00478.25 CCF48602.1 - 0.00011 21.4 0.0 0.00019 20.6 0.0 1.3 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain Glu_synthase PF01645.17 CCF48602.1 - 0.00015 21.1 0.0 0.00025 20.3 0.0 1.2 1 0 0 1 1 1 1 Conserved region in glutamate synthase ThiG PF05690.14 CCF48602.1 - 0.0082 15.5 0.0 1.9 7.7 0.0 2.3 2 0 0 2 2 2 2 Thiazole biosynthesis protein ThiG Amidase PF01425.21 CCF48603.1 - 5.5e-105 351.9 1.3 1.4e-104 350.6 1.3 1.6 1 1 0 1 1 1 1 Amidase Response_reg PF00072.24 CCF48605.1 - 1.8e-16 60.3 0.0 3.2e-16 59.5 0.0 1.4 1 0 0 1 1 1 1 Response regulator receiver domain Tropomyosin_1 PF12718.7 CCF48606.1 - 1.5e-47 161.3 30.5 1.8e-47 161.1 30.5 1.0 1 0 0 1 1 1 1 Tropomyosin like Tropomyosin PF00261.20 CCF48606.1 - 1e-10 41.4 30.1 7.8e-06 25.4 9.0 2.9 1 1 2 3 3 3 3 Tropomyosin CENP-F_leu_zip PF10473.9 CCF48606.1 - 5.1e-06 26.5 30.5 5.2e-05 23.3 8.2 3.0 1 1 2 3 3 3 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF3450 PF11932.8 CCF48606.1 - 1.2e-05 24.8 24.3 0.00026 20.4 11.7 2.0 1 1 1 2 2 2 2 Protein of unknown function (DUF3450) GAS PF13851.6 CCF48606.1 - 0.00015 21.2 28.8 0.00044 19.7 28.8 1.7 1 1 0 1 1 1 1 Growth-arrest specific micro-tubule binding DUF1664 PF07889.12 CCF48606.1 - 0.00057 19.9 11.5 0.0011 19.0 3.3 2.3 1 1 1 2 2 2 1 Protein of unknown function (DUF1664) TMF_DNA_bd PF12329.8 CCF48606.1 - 0.00094 19.1 29.6 0.044 13.8 3.3 3.2 1 1 2 3 3 3 2 TATA element modulatory factor 1 DNA binding Uso1_p115_C PF04871.13 CCF48606.1 - 0.0015 18.9 13.9 0.0015 18.9 13.9 2.2 1 1 1 2 2 2 1 Uso1 / p115 like vesicle tethering protein, C terminal region FliD_C PF07195.12 CCF48606.1 - 0.0016 17.9 13.2 0.021 14.3 6.6 2.9 1 1 1 2 2 2 1 Flagellar hook-associated protein 2 C-terminus DHR10 PF18595.1 CCF48606.1 - 0.0027 17.7 34.3 0.029 14.4 10.7 3.0 1 1 2 3 3 3 2 Designed helical repeat protein 10 domain Jnk-SapK_ap_N PF09744.9 CCF48606.1 - 0.0029 17.9 32.3 0.0055 16.9 21.7 2.0 1 1 1 2 2 2 1 JNK_SAPK-associated protein-1 Csm1_N PF18504.1 CCF48606.1 - 0.0032 17.8 26.7 0.018 15.4 5.4 3.6 1 1 2 3 3 3 2 Csm1 N-terminal domain KELK PF15796.5 CCF48606.1 - 0.004 17.6 2.7 0.004 17.6 2.7 3.4 2 2 1 3 3 3 2 KELK-motif containing domain of MRCK Ser/Thr protein kinase Spc7 PF08317.11 CCF48606.1 - 0.0048 15.8 28.3 0.085 11.7 13.7 2.0 1 1 1 2 2 2 2 Spc7 kinetochore protein EzrA PF06160.12 CCF48606.1 - 0.0048 15.1 21.0 0.0049 15.1 10.3 2.1 1 1 1 2 2 2 1 Septation ring formation regulator, EzrA HOOK PF05622.12 CCF48606.1 - 0.0049 15.1 26.0 0.0061 14.8 26.0 1.0 1 0 0 1 1 1 1 HOOK protein HMMR_N PF15905.5 CCF48606.1 - 0.0049 16.4 25.1 0.0075 15.8 25.1 1.2 1 0 0 1 1 1 1 Hyaluronan mediated motility receptor N-terminal HrpB7 PF09486.10 CCF48606.1 - 0.0057 17.1 21.6 0.057 13.8 5.8 2.5 1 1 1 2 2 2 2 Bacterial type III secretion protein (HrpB7) FlxA PF14282.6 CCF48606.1 - 0.0068 16.4 2.4 0.0068 16.4 2.4 2.6 1 1 2 3 3 3 1 FlxA-like protein Phage_GP20 PF06810.11 CCF48606.1 - 0.0091 15.8 21.6 0.12 12.2 6.5 2.4 1 1 2 3 3 3 3 Phage minor structural protein GP20 TPR_MLP1_2 PF07926.12 CCF48606.1 - 0.0098 15.9 32.4 0.088 12.9 19.1 2.5 1 1 1 2 2 2 2 TPR/MLP1/MLP2-like protein ADIP PF11559.8 CCF48606.1 - 0.01 15.9 27.3 0.42 10.7 1.3 3.1 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding TRAF_BIRC3_bd PF16673.5 CCF48606.1 - 0.017 14.9 3.9 0.017 14.9 3.9 3.3 3 1 0 3 3 3 0 TNF receptor-associated factor BIRC3 binding domain Fib_alpha PF08702.10 CCF48606.1 - 0.018 15.3 12.6 0.67 10.1 3.7 2.6 1 1 0 2 2 2 0 Fibrinogen alpha/beta chain family ATG16 PF08614.11 CCF48606.1 - 0.021 15.1 31.2 0.13 12.5 17.1 2.2 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) ERM PF00769.19 CCF48606.1 - 0.03 14.1 31.0 0.0094 15.8 27.4 1.7 1 1 0 1 1 1 0 Ezrin/radixin/moesin family DUF3584 PF12128.8 CCF48606.1 - 0.042 11.4 25.7 0.034 11.7 12.2 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) DUF724 PF05266.14 CCF48606.1 - 0.056 13.3 22.9 0.074 12.9 7.6 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF724) FlaC_arch PF05377.11 CCF48606.1 - 0.061 13.7 15.9 2.1 8.8 1.0 4.4 2 2 2 4 4 4 0 Flagella accessory protein C (FlaC) DUF4200 PF13863.6 CCF48606.1 - 0.072 13.5 26.9 0.39 11.1 6.0 2.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) DUF4407 PF14362.6 CCF48606.1 - 0.092 12.1 20.5 1.4 8.2 20.5 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Laminin_II PF06009.12 CCF48606.1 - 0.098 12.7 16.0 0.05 13.6 5.6 2.2 1 1 1 2 2 2 0 Laminin Domain II DUF812 PF05667.11 CCF48606.1 - 0.1 11.5 25.8 0.45 9.3 14.3 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF812) DUF4201 PF13870.6 CCF48606.1 - 0.1 12.3 22.8 0.48 10.1 6.6 2.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4201) Lebercilin PF15619.6 CCF48606.1 - 0.1 12.2 29.7 5.6 6.6 16.8 2.4 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease Sec34 PF04136.15 CCF48606.1 - 0.1 12.5 13.8 0.056 13.3 3.7 2.3 1 1 1 2 2 2 0 Sec34-like family PI3K_P85_iSH2 PF16454.5 CCF48606.1 - 0.11 12.1 24.1 1 8.9 3.7 3.0 1 1 2 3 3 3 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain PsbQ PF05757.11 CCF48606.1 - 0.12 12.1 7.7 0.021 14.5 3.5 1.7 1 1 0 2 2 2 0 Oxygen evolving enhancer protein 3 (PsbQ) XhlA PF10779.9 CCF48606.1 - 0.12 12.6 23.1 2.9 8.2 2.5 4.1 1 1 3 4 4 4 0 Haemolysin XhlA KLRAQ PF10205.9 CCF48606.1 - 0.15 12.3 19.0 0.73 10.1 8.6 2.6 1 1 2 3 3 3 0 Predicted coiled-coil domain-containing protein KASH_CCD PF14662.6 CCF48606.1 - 0.15 11.8 27.1 0.41 10.4 10.4 2.1 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 or KASH APG6_N PF17675.1 CCF48606.1 - 0.18 12.3 37.1 0.086 13.4 21.2 2.1 1 1 1 2 2 2 0 Apg6 coiled-coil region DUF3552 PF12072.8 CCF48606.1 - 0.2 11.1 26.2 1.1 8.7 14.7 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF3552) Prefoldin_2 PF01920.20 CCF48606.1 - 0.2 11.6 25.8 0.3 11.1 2.4 3.8 1 1 2 3 3 3 0 Prefoldin subunit Fzo_mitofusin PF04799.13 CCF48606.1 - 0.21 11.1 12.8 0.036 13.6 4.8 2.3 1 1 1 2 2 2 0 fzo-like conserved region DUF4559 PF15112.6 CCF48606.1 - 0.24 11.0 13.6 0.93 9.1 2.2 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4559) Fez1 PF06818.15 CCF48606.1 - 0.24 11.8 25.4 1.7 9.1 25.4 1.9 1 1 0 1 1 1 0 Fez1 Uds1 PF15456.6 CCF48606.1 - 0.27 11.4 24.5 2.8 8.1 5.1 3.0 1 1 0 2 2 2 0 Up-regulated During Septation Leu_zip PF15294.6 CCF48606.1 - 0.28 10.6 21.8 0.094 12.2 5.3 2.1 1 1 1 2 2 2 0 Leucine zipper BRE1 PF08647.11 CCF48606.1 - 0.33 11.1 25.8 0.13 12.4 8.3 2.2 2 0 0 2 2 2 0 BRE1 E3 ubiquitin ligase Borrelia_P83 PF05262.11 CCF48606.1 - 0.41 9.1 22.3 0.46 8.9 22.3 1.0 1 0 0 1 1 1 0 Borrelia P83/100 protein GrpE PF01025.19 CCF48606.1 - 0.43 10.2 25.6 0.11 12.1 3.0 3.1 1 1 2 3 3 3 0 GrpE BLOC1_2 PF10046.9 CCF48606.1 - 0.47 10.8 17.9 0.82 10.0 7.2 3.1 1 1 2 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 TMF_TATA_bd PF12325.8 CCF48606.1 - 0.47 10.7 27.3 1.3 9.3 14.7 2.6 1 1 2 3 3 3 0 TATA element modulatory factor 1 TATA binding SlyX PF04102.12 CCF48606.1 - 0.48 11.1 19.5 1.7 9.3 1.8 3.7 1 1 3 4 4 3 0 SlyX PspA_IM30 PF04012.12 CCF48606.1 - 0.51 9.9 27.3 8.5 5.9 27.0 2.6 1 1 0 1 1 1 0 PspA/IM30 family YlqD PF11068.8 CCF48606.1 - 0.51 10.7 18.1 0.04 14.3 6.5 2.8 1 1 2 3 3 3 0 YlqD protein FPP PF05911.11 CCF48606.1 - 0.51 8.5 25.4 1.2 7.3 25.4 1.6 1 1 0 1 1 1 0 Filament-like plant protein, long coiled-coil NPV_P10 PF05531.12 CCF48606.1 - 0.68 10.4 9.8 1.9 9.0 1.1 3.4 1 1 3 4 4 4 0 Nucleopolyhedrovirus P10 protein TraF_2 PF13729.6 CCF48606.1 - 0.81 9.0 4.5 0.68 9.3 0.2 2.0 2 0 0 2 2 2 0 F plasmid transfer operon, TraF, protein TolA_bind_tri PF16331.5 CCF48606.1 - 0.81 9.8 16.9 1.1 9.4 1.7 3.4 1 1 2 3 3 3 0 TolA binding protein trimerisation CHDCT2 PF08074.11 CCF48606.1 - 0.82 9.8 11.4 0.2 11.8 5.4 2.0 1 1 1 2 2 2 0 CHDCT2 (NUC038) domain TMPIT PF07851.13 CCF48606.1 - 0.83 8.8 17.6 0.18 11.0 8.3 2.0 1 1 1 2 2 2 0 TMPIT-like protein OmpH PF03938.14 CCF48606.1 - 0.85 10.0 23.7 2.1 8.7 14.7 2.4 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) bZIP_1 PF00170.21 CCF48606.1 - 0.88 9.7 18.8 1.3 9.2 2.3 3.6 2 2 1 3 3 3 0 bZIP transcription factor IFT57 PF10498.9 CCF48606.1 - 0.95 8.4 18.3 6.3 5.7 9.6 2.4 1 1 1 2 2 2 0 Intra-flagellar transport protein 57 Med21 PF11221.8 CCF48606.1 - 1.1 9.5 22.0 0.69 10.2 12.8 2.6 1 1 1 2 2 2 0 Subunit 21 of Mediator complex AAA_13 PF13166.6 CCF48606.1 - 1.1 7.8 19.5 1.4 7.5 19.5 1.2 1 0 0 1 1 1 0 AAA domain UPF0242 PF06785.11 CCF48606.1 - 1.2 9.2 27.6 0.83 9.7 15.6 2.1 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Cep57_CLD_2 PF14197.6 CCF48606.1 - 1.3 9.2 29.3 2.1 8.5 11.7 3.4 2 1 1 3 3 3 0 Centrosome localisation domain of PPC89 DUF3287 PF11690.8 CCF48606.1 - 1.3 8.7 6.2 3.2 7.5 0.8 2.7 1 1 2 3 3 3 0 Protein of unknown function (DUF3287) Atg14 PF10186.9 CCF48606.1 - 1.5 7.8 22.0 0.3 10.1 6.9 2.0 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 Prominin PF05478.11 CCF48606.1 - 1.5 6.6 9.3 1.8 6.4 9.3 1.2 1 0 0 1 1 1 0 Prominin CTNNBL PF08216.11 CCF48606.1 - 1.6 9.0 9.4 0.21 11.8 3.6 2.3 1 1 2 3 3 2 0 Catenin-beta-like, Arm-motif containing nuclear DUF4472 PF14739.6 CCF48606.1 - 1.6 9.5 22.4 18 6.1 12.1 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4472) Tup_N PF08581.10 CCF48606.1 - 1.7 9.0 21.3 1.3 9.3 5.3 2.9 1 1 2 3 3 3 0 Tup N-terminal DUF16 PF01519.16 CCF48606.1 - 1.9 9.0 17.1 1.2e+04 -3.2 17.1 2.7 1 1 0 1 1 0 0 Protein of unknown function DUF16 CENP-K PF11802.8 CCF48606.1 - 2 7.9 19.6 0.14 11.7 8.3 2.1 1 1 1 2 2 2 0 Centromere-associated protein K HetR_C PF18460.1 CCF48606.1 - 2.1 8.3 7.1 0.64 10.0 0.9 2.9 2 2 3 5 5 3 0 Heterocyst differentiation regulator C-terminal Hood domain DUF641 PF04859.12 CCF48606.1 - 2.2 8.6 20.2 0.18 12.1 2.6 2.8 1 1 0 2 2 2 0 Plant protein of unknown function (DUF641) CLZ PF16526.5 CCF48606.1 - 2.3 8.6 24.9 7.8 6.9 5.7 3.5 1 1 2 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels YabA PF06156.13 CCF48606.1 - 2.3 8.9 18.3 9.6 6.9 5.9 2.4 1 1 1 2 2 2 0 Initiation control protein YabA CENP-H PF05837.12 CCF48606.1 - 2.6 8.5 24.0 1.5 9.2 9.0 2.2 1 1 0 2 2 2 0 Centromere protein H (CENP-H) WXG100 PF06013.12 CCF48606.1 - 2.6 8.3 12.1 21 5.4 1.2 3.6 2 1 2 4 4 4 0 Proteins of 100 residues with WXG HisKA_3 PF07730.13 CCF48606.1 - 3 8.4 15.1 17 6.0 3.8 3.9 1 1 2 3 3 3 0 Histidine kinase Cluap1 PF10234.9 CCF48606.1 - 3.1 7.1 22.0 2.3 7.5 8.0 2.1 1 1 1 2 2 2 0 Clusterin-associated protein-1 DUF919 PF06034.11 CCF48606.1 - 3.4 7.6 9.6 1.8 8.4 1.2 3.2 3 0 0 3 3 2 0 Nucleopolyhedrovirus protein of unknown function (DUF919) DegS PF05384.11 CCF48606.1 - 3.5 7.1 21.7 4.3 6.8 1.4 3.1 1 1 1 3 3 3 0 Sensor protein DegS T3SSipB PF16535.5 CCF48606.1 - 3.5 8.1 17.7 79 3.7 17.7 2.2 1 1 0 1 1 1 0 Type III cell invasion protein SipB Lectin_N PF03954.14 CCF48606.1 - 3.5 7.4 12.6 2.3 8.0 1.0 2.9 1 1 2 3 3 3 0 Hepatic lectin, N-terminal domain Exonuc_VII_L PF02601.15 CCF48606.1 - 3.7 7.0 17.0 6.8 6.2 17.0 1.5 1 1 0 1 1 1 0 Exonuclease VII, large subunit FAP206 PF12018.8 CCF48606.1 - 3.9 6.9 12.5 0.35 10.3 5.8 1.9 1 1 1 2 2 2 0 Domain of unknown function Prefoldin PF02996.17 CCF48606.1 - 4 7.4 23.3 1.3 8.9 3.0 4.0 1 1 2 4 4 4 0 Prefoldin subunit DUF948 PF06103.11 CCF48606.1 - 4.1 7.7 9.6 18 5.6 3.1 2.7 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Swi5 PF07061.11 CCF48606.1 - 4.2 7.5 21.4 1.8 8.7 1.0 3.9 1 1 2 3 3 3 0 Swi5 LPP PF04728.13 CCF48606.1 - 4.4 7.8 10.2 40 4.7 0.1 4.0 3 1 1 4 4 4 0 Lipoprotein leucine-zipper DUF4446 PF14584.6 CCF48606.1 - 4.9 7.1 13.5 4.4 7.3 2.3 2.8 1 1 2 3 3 3 0 Protein of unknown function (DUF4446) HemX PF04375.14 CCF48606.1 - 6.4 5.9 20.0 7 5.8 8.4 2.1 1 1 1 2 2 2 0 HemX, putative uroporphyrinogen-III C-methyltransferase GCN5L1 PF06320.13 CCF48606.1 - 6.8 6.9 17.6 0.66 10.1 9.4 2.1 1 1 1 2 2 2 0 GCN5-like protein 1 (GCN5L1) HIP1_clath_bdg PF16515.5 CCF48606.1 - 7.4 7.3 25.8 1.7 9.3 7.8 2.7 1 1 2 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 HAUS-augmin3 PF14932.6 CCF48606.1 - 7.7 6.0 26.2 1.6 8.2 14.3 2.0 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 3 Sec2p PF06428.11 CCF48606.1 - 8 6.5 25.2 6 6.9 7.0 3.5 1 1 2 3 3 3 0 GDP/GTP exchange factor Sec2p Spectrin PF00435.21 CCF48606.1 - 8.5 6.9 23.5 4.4 7.9 12.6 3.2 1 1 1 2 2 2 0 Spectrin repeat FAM76 PF16046.5 CCF48606.1 - 8.8 5.6 17.2 4.5 6.5 8.5 2.1 1 1 1 2 2 2 0 FAM76 protein bZIP_2 PF07716.15 CCF48606.1 - 9.5 6.4 21.2 2 8.6 3.7 4.0 2 2 0 3 3 3 0 Basic region leucine zipper Kinesin PF00225.23 CCF48607.1 - 2e-95 319.5 0.1 2e-95 319.5 0.1 1.7 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 CCF48607.1 - 2.7e-50 170.2 0.0 7.8e-50 168.7 0.0 1.9 1 0 0 1 1 1 1 Microtubule binding DMPK_coil PF08826.10 CCF48607.1 - 0.002 18.2 0.9 0.002 18.2 0.9 4.0 4 1 1 5 5 5 2 DMPK coiled coil domain like UpxZ PF06603.11 CCF48607.1 - 0.023 15.0 0.0 0.53 10.6 0.0 2.8 2 0 0 2 2 2 0 UpxZ family of transcription anti-terminator antagonists LPP PF04728.13 CCF48607.1 - 0.026 14.9 1.4 0.026 14.9 1.4 3.9 4 0 0 4 4 4 0 Lipoprotein leucine-zipper FAM76 PF16046.5 CCF48607.1 - 0.26 10.6 16.0 0.5 9.7 16.0 1.5 1 0 0 1 1 1 0 FAM76 protein Bac_DnaA PF00308.18 CCF48607.1 - 0.27 11.1 0.0 0.27 11.1 0.0 2.6 2 1 1 3 3 3 0 Bacterial dnaA protein AAA_22 PF13401.6 CCF48607.1 - 0.56 10.5 5.1 0.91 9.8 0.0 3.1 3 0 0 3 3 3 0 AAA domain DUF1664 PF07889.12 CCF48607.1 - 8 6.5 10.9 1.4 8.9 5.2 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) TRAUB PF08164.12 CCF48608.1 - 4.3e-26 91.2 3.0 8.2e-25 87.1 0.0 3.1 3 0 0 3 3 3 1 Apoptosis-antagonizing transcription factor, C-terminal AATF-Che1 PF13339.6 CCF48608.1 - 2.5e-22 80.1 0.8 2.5e-22 80.1 0.8 3.2 2 1 0 2 2 2 1 Apoptosis antagonizing transcription factor Nsp1_C PF05064.13 CCF48609.1 - 5.3e-29 100.4 0.0 9.5e-29 99.6 0.0 1.3 1 0 0 1 1 1 1 Nsp1-like C-terminal region MCU PF04678.13 CCF48610.1 - 0.075 13.1 1.5 0.16 12.0 1.5 1.5 1 0 0 1 1 1 0 Mitochondrial calcium uniporter Agarase_CBM PF17992.1 CCF48610.1 - 0.083 12.4 2.0 0.4 10.2 0.1 2.5 3 0 0 3 3 3 0 Agarase CBM like domain Ribosomal_L2_C PF03947.18 CCF48611.1 - 1.2e-51 174.2 6.3 4.5e-51 172.3 0.7 2.8 2 1 0 2 2 2 2 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 CCF48611.1 - 1.3e-25 89.2 0.7 3e-25 88.0 0.7 1.7 1 0 0 1 1 1 1 Ribosomal Proteins L2, RNA binding domain DnaJ PF00226.31 CCF48612.1 - 4.6e-20 71.5 0.7 1.2e-19 70.1 0.0 2.1 2 0 0 2 2 2 1 DnaJ domain NuDC PF16273.5 CCF48612.1 - 0.033 14.7 0.5 0.033 14.7 0.5 4.2 4 0 0 4 4 4 0 Nuclear distribution C domain Glyco_transf_22 PF03901.17 CCF48613.1 - 2.5e-36 125.8 21.0 1.4e-28 100.3 10.0 2.1 2 0 0 2 2 2 2 Alg9-like mannosyltransferase family VMA21 PF09446.10 CCF48613.1 - 0.037 14.1 0.6 0.16 12.1 0.6 2.2 1 0 0 1 1 1 0 VMA21-like domain FAM76 PF16046.5 CCF48615.1 - 0.31 10.3 1.2 0.4 10.0 1.2 1.1 1 0 0 1 1 1 0 FAM76 protein Apt1 PF10351.9 CCF48615.1 - 1.6 7.5 15.1 2.2 7.1 15.1 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain SOG2 PF10428.9 CCF48615.1 - 3.7 6.6 24.1 4.6 6.3 24.1 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein DUF4834 PF16118.5 CCF48615.1 - 8.5 7.4 7.5 4.7 8.3 0.8 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4834) TPR_1 PF00515.28 CCF48616.1 - 6.5e-09 35.2 3.4 0.00012 21.8 0.0 4.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 CCF48616.1 - 2.1e-08 33.7 10.9 1.3e-05 24.9 0.0 5.7 6 0 0 6 6 6 2 Tetratricopeptide repeat ANAPC3 PF12895.7 CCF48616.1 - 2.1e-06 27.9 0.8 8.2e-06 26.0 0.8 2.1 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 CCF48616.1 - 2.9e-06 27.7 1.6 0.031 14.8 0.0 6.1 5 1 1 6 6 6 1 Tetratricopeptide repeat TPR_17 PF13431.6 CCF48616.1 - 3.6e-06 27.0 0.2 0.46 11.0 0.0 4.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_9 PF13371.6 CCF48616.1 - 1.1e-05 25.5 1.0 0.0035 17.5 0.0 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 CCF48616.1 - 3e-05 23.9 2.1 0.0063 16.6 0.0 5.0 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_7 PF13176.6 CCF48616.1 - 6.3e-05 22.7 2.9 0.0078 16.2 0.0 4.9 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_16 PF13432.6 CCF48616.1 - 0.00026 21.6 0.0 0.00071 20.2 0.0 3.9 2 1 2 4 4 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 CCF48616.1 - 0.0025 17.5 0.0 0.52 10.0 0.0 3.6 2 1 1 3 3 3 1 TPR repeat CnrY PF17524.2 CCF48616.1 - 0.068 13.4 0.0 0.34 11.2 0.0 2.2 1 0 0 1 1 1 0 Anti-sigma factor CnrY SPO22 PF08631.10 CCF48616.1 - 0.073 12.5 0.5 2.6 7.4 0.0 2.8 2 0 0 2 2 2 0 Meiosis protein SPO22/ZIP4 like TPR_12 PF13424.6 CCF48616.1 - 0.13 12.6 9.1 1.3 9.3 0.1 4.3 5 1 1 6 6 5 0 Tetratricopeptide repeat TPR_14 PF13428.6 CCF48616.1 - 0.86 10.6 20.4 4.2 8.4 0.0 8.1 8 0 0 8 8 8 0 Tetratricopeptide repeat TPR_6 PF13174.6 CCF48616.1 - 1.8 9.3 6.8 11 6.9 0.0 4.6 5 0 0 5 5 3 0 Tetratricopeptide repeat DUF3835 PF12927.7 CCF48617.1 - 0.017 16.0 0.3 0.017 16.0 0.3 6.6 6 1 0 6 6 6 0 Domain of unknown function (DUF3835) HECT PF00632.25 CCF48618.1 - 1.8e-73 247.7 0.0 2.7e-73 247.2 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) DEAD PF00270.29 CCF48619.1 - 2.4e-48 164.2 0.0 4.2e-48 163.4 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CCF48619.1 - 4.6e-25 88.1 0.1 1.7e-24 86.3 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 CCF48619.1 - 8.2e-18 64.4 0.2 1.8e-17 63.3 0.2 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 CCF48619.1 - 7.1e-06 26.1 0.0 3.7e-05 23.8 0.0 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Rad21_Rec8_N PF04825.13 CCF48621.1 - 0.012 15.8 0.1 0.028 14.6 0.1 1.6 1 0 0 1 1 1 0 N terminus of Rad21 / Rec8 like protein Cupin_8 PF13621.6 CCF48622.1 - 7.1e-09 35.7 0.1 5e-08 33.0 0.0 2.3 1 1 1 2 2 2 1 Cupin-like domain JHD PF17811.1 CCF48622.1 - 1.4e-06 28.7 0.0 4.8e-06 27.0 0.0 1.9 1 0 0 1 1 1 1 Jumonji helical domain JmjC PF02373.22 CCF48622.1 - 3.5e-06 27.4 0.1 0.00013 22.4 0.1 2.7 1 1 0 1 1 1 1 JmjC domain, hydroxylase PHD PF00628.29 CCF48622.1 - 0.00024 20.9 14.5 0.00057 19.7 14.5 1.7 1 1 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 CCF48622.1 - 0.12 11.9 10.3 0.3 10.7 10.3 1.7 1 0 0 1 1 1 0 PHD-finger Ammonium_transp PF00909.21 CCF48623.1 - 2.1e-105 352.7 29.0 2.4e-105 352.5 29.0 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family DUF3464 PF11947.8 CCF48624.1 - 0.068 12.9 0.0 0.2 11.4 0.0 1.9 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 Kinesin PF00225.23 CCF48625.1 - 7.7e-96 320.9 0.0 1.1e-95 320.4 0.0 1.2 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 CCF48625.1 - 1.9e-19 70.1 0.0 4.6e-19 68.8 0.0 1.6 1 0 0 1 1 1 1 Microtubule binding TMF_DNA_bd PF12329.8 CCF48625.1 - 0.026 14.5 0.9 0.026 14.5 0.9 3.1 3 0 0 3 3 3 0 TATA element modulatory factor 1 DNA binding DUF4230 PF14014.6 CCF48625.1 - 0.039 14.2 0.5 0.094 13.0 0.5 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4230) Snapin_Pallidin PF14712.6 CCF48625.1 - 0.27 11.7 2.3 0.94 9.9 1.3 2.4 1 1 1 2 2 2 0 Snapin/Pallidin PKcGMP_CC PF16808.5 CCF48625.1 - 0.78 9.6 10.8 2.4 8.1 2.2 2.7 2 0 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase DUF2015 PF09435.10 CCF48626.1 - 7.7e-26 90.2 0.0 1.2e-25 89.5 0.0 1.3 1 1 0 1 1 1 1 Fungal protein of unknown function (DUF2015) DNA_pol_B PF00136.21 CCF48628.1 - 1.3e-117 393.3 0.0 1.9e-117 392.8 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase family B zf-DNA_Pol PF08996.10 CCF48628.1 - 1.8e-60 203.8 0.1 3.1e-60 203.1 0.1 1.4 1 0 0 1 1 1 1 DNA Polymerase alpha zinc finger DNA_pol_B_exo1 PF03104.19 CCF48628.1 - 1.2e-29 103.6 0.0 2.3e-29 102.6 0.0 1.5 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain DNA_pol_alpha_N PF12254.8 CCF48628.1 - 2.2e-20 72.5 3.0 2.2e-20 72.5 3.0 2.7 3 0 0 3 3 3 1 DNA polymerase alpha subunit p180 N terminal VWA_N2 PF16164.5 CCF48628.1 - 0.021 14.9 0.2 0.06 13.5 0.2 1.7 1 0 0 1 1 1 0 VWA N-terminal Mito_carr PF00153.27 CCF48629.1 - 4.9e-30 103.3 3.7 6.7e-16 58.0 0.3 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein PRKCSH PF07915.13 CCF48630.1 - 3.6e-14 53.5 0.2 1.4e-09 38.8 0.0 3.0 2 0 0 2 2 2 2 Glucosidase II beta subunit-like protein PRKCSH_1 PF13015.6 CCF48630.1 - 0.093 12.4 0.0 0.2 11.4 0.0 1.4 1 0 0 1 1 1 0 Glucosidase II beta subunit-like protein PX PF00787.24 CCF48631.1 - 4.8e-21 74.9 0.0 1.1e-20 73.7 0.0 1.6 1 0 0 1 1 1 1 PX domain Vps5 PF09325.10 CCF48631.1 - 0.00014 21.5 7.7 0.0073 15.9 1.1 2.3 2 0 0 2 2 2 2 Vps5 C terminal like MRP-S27 PF10037.9 CCF48631.1 - 0.037 12.9 1.1 0.75 8.6 0.1 2.3 2 0 0 2 2 2 0 Mitochondrial 28S ribosomal protein S27 Anillin PF08174.11 CCF48631.1 - 0.039 14.4 0.1 0.083 13.3 0.1 1.5 1 0 0 1 1 1 0 Cell division protein anillin MAP65_ASE1 PF03999.12 CCF48631.1 - 0.047 12.4 0.7 0.1 11.2 0.7 1.8 1 1 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) BAR_3_WASP_bdg PF10456.9 CCF48631.1 - 0.053 13.0 0.6 0.11 11.9 0.1 1.8 2 0 0 2 2 2 0 WASP-binding domain of Sorting nexin protein Spore_III_AB PF09548.10 CCF48631.1 - 1.8 8.7 6.5 3.3 7.8 0.1 3.2 3 1 1 4 4 4 0 Stage III sporulation protein AB (spore_III_AB) FAD_binding_4 PF01565.23 CCF48635.1 - 7.1e-22 77.6 0.3 1.3e-21 76.8 0.3 1.4 1 0 0 1 1 1 1 FAD binding domain Exo5 PF09810.9 CCF48637.1 - 9.3e-49 166.9 0.0 1.4e-41 143.2 0.0 2.6 1 1 1 2 2 2 2 Exonuclease V - a 5' deoxyribonuclease AP2 PF00847.20 CCF48637.1 - 2.1 8.7 7.6 11 6.3 0.1 2.8 2 0 0 2 2 2 0 AP2 domain GPI2 PF06432.11 CCF48638.1 - 4e-65 220.0 8.0 5.8e-65 219.5 8.0 1.2 1 0 0 1 1 1 1 Phosphatidylinositol N-acetylglucosaminyltransferase MPP6 PF10175.9 CCF48638.1 - 0.0079 16.7 2.8 0.051 14.1 2.6 2.2 1 1 0 1 1 1 1 M-phase phosphoprotein 6 MFS_1 PF07690.16 CCF48640.1 - 2.7e-28 98.9 23.0 8.6e-26 90.7 24.4 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily NAD_kinase PF01513.21 CCF48641.1 - 3.6e-55 187.2 0.0 5.9e-55 186.5 0.0 1.3 1 0 0 1 1 1 1 ATP-NAD kinase DAGK_cat PF00781.24 CCF48641.1 - 0.018 14.6 0.0 0.049 13.3 0.0 1.7 1 0 0 1 1 1 0 Diacylglycerol kinase catalytic domain Ccdc124 PF06244.12 CCF48642.1 - 2.2e-25 89.7 18.5 2.2e-25 89.7 18.5 2.4 2 1 0 2 2 2 1 Coiled-coil domain-containing protein 124 /Oxs1 DUF2852 PF11014.8 CCF48642.1 - 5.4 7.2 14.4 0.079 13.1 0.9 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF2852) Rhodanese PF00581.20 CCF48643.1 - 4.7e-16 59.2 0.0 7e-16 58.7 0.0 1.3 1 0 0 1 1 1 1 Rhodanese-like domain UQ_con PF00179.26 CCF48644.1 - 1.3e-46 157.8 0.0 1.4e-46 157.6 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 CCF48644.1 - 0.0014 18.4 0.0 0.0017 18.1 0.0 1.1 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 CCF48644.1 - 0.13 12.6 0.3 0.15 12.4 0.3 1.4 1 1 0 1 1 1 0 RWD domain Pkinase PF00069.25 CCF48645.1 - 9.6e-51 172.7 0.2 1.8e-50 171.7 0.2 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF48645.1 - 6.4e-21 74.8 0.0 1.2e-20 73.9 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Pox_ser-thr_kin PF05445.11 CCF48645.1 - 0.017 14.1 0.1 0.031 13.3 0.1 1.3 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Kdo PF06293.14 CCF48645.1 - 0.076 12.4 0.1 0.12 11.7 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF5344 PF17279.2 CCF48646.1 - 0.028 15.0 0.8 0.091 13.3 0.1 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5344) Med25_VWA PF11265.8 CCF48646.1 - 0.15 11.8 0.2 0.31 10.8 0.1 1.5 2 0 0 2 2 2 0 Mediator complex subunit 25 von Willebrand factor type A CLASP_N PF12348.8 CCF48647.1 - 7.3e-64 215.4 4.0 5.5e-29 101.4 0.0 4.6 4 1 1 5 5 5 4 CLASP N terminal HEAT PF02985.22 CCF48647.1 - 0.00025 21.0 2.2 0.66 10.4 0.1 4.7 5 0 0 5 5 5 2 HEAT repeat IFRD PF05004.13 CCF48647.1 - 0.0014 17.8 1.1 0.47 9.5 0.0 3.5 3 0 0 3 3 3 2 Interferon-related developmental regulator (IFRD) Cnd1 PF12717.7 CCF48647.1 - 0.11 12.6 0.2 10 6.2 0.0 3.4 3 0 0 3 3 3 0 non-SMC mitotic condensation complex subunit 1 Sin_N PF04801.13 CCF48647.1 - 1.1 8.3 7.0 2 7.5 7.0 1.3 1 0 0 1 1 1 0 Sin-like protein conserved region UPF0029 PF01205.19 CCF48648.1 - 1.1e-19 70.7 3.6 2.2e-19 69.7 0.0 3.3 3 1 0 3 3 3 1 Uncharacterized protein family UPF0029 Dimerisation PF08100.11 CCF48648.1 - 0.24 11.5 0.4 0.73 9.9 0.0 2.0 2 0 0 2 2 2 0 Dimerisation domain AAA PF00004.29 CCF48649.1 - 1.6e-40 138.5 0.0 3e-40 137.7 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 CCF48649.1 - 1.6e-21 76.0 0.1 3.4e-21 75.0 0.1 1.6 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_lid_3 PF17862.1 CCF48649.1 - 1.6e-10 40.6 0.1 4.2e-10 39.3 0.1 1.7 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 CCF48649.1 - 0.00021 21.7 0.3 0.051 14.0 0.0 2.4 1 1 1 2 2 2 1 AAA ATPase domain AAA_5 PF07728.14 CCF48649.1 - 0.00028 20.9 0.2 0.0037 17.3 0.2 2.6 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 CCF48649.1 - 0.00034 20.8 0.5 0.0044 17.1 0.0 2.7 2 1 0 2 2 2 1 AAA domain (Cdc48 subfamily) PhoH PF02562.16 CCF48649.1 - 0.00064 19.2 0.4 0.016 14.6 0.0 2.6 3 0 0 3 3 3 1 PhoH-like protein RuvB_N PF05496.12 CCF48649.1 - 0.0013 18.5 0.0 0.0032 17.2 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 CCF48649.1 - 0.0039 17.5 2.6 0.11 12.7 0.0 2.7 2 1 0 3 3 3 1 AAA domain AAA_33 PF13671.6 CCF48649.1 - 0.01 16.0 0.0 0.023 14.8 0.0 1.7 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 CCF48649.1 - 0.014 14.8 0.1 0.05 13.0 0.1 1.9 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_11 PF13086.6 CCF48649.1 - 0.015 15.1 0.2 0.27 11.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain DUF815 PF05673.13 CCF48649.1 - 0.032 13.4 0.0 0.058 12.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF815) CENP-F_leu_zip PF10473.9 CCF48649.1 - 0.041 13.9 1.4 0.1 12.6 1.4 1.7 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 AAA_14 PF13173.6 CCF48649.1 - 0.052 13.6 0.0 0.45 10.5 0.0 2.3 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 CCF48649.1 - 0.075 12.8 0.0 0.16 11.7 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_24 PF13479.6 CCF48649.1 - 0.12 12.0 0.1 0.32 10.7 0.1 1.8 1 1 0 1 1 1 0 AAA domain ATPase PF06745.13 CCF48649.1 - 0.13 11.6 0.3 0.39 10.0 0.0 2.0 2 0 0 2 2 2 0 KaiC RPN7 PF10602.9 CCF48650.1 - 3.4e-48 163.6 0.0 6.9e-48 162.6 0.0 1.5 1 0 0 1 1 1 1 26S proteasome subunit RPN7 PCI PF01399.27 CCF48650.1 - 8.6e-13 48.7 0.1 2.8e-12 47.1 0.0 1.9 2 0 0 2 2 2 1 PCI domain TPR_2 PF07719.17 CCF48650.1 - 0.00079 19.4 1.1 0.095 12.9 0.0 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 CCF48650.1 - 0.0077 16.5 0.8 0.11 12.8 0.0 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.6 CCF48650.1 - 0.031 14.8 0.2 1.5 9.3 0.3 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.6 CCF48650.1 - 0.043 13.8 0.1 1.4 9.1 0.0 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_4 PF07721.14 CCF48650.1 - 0.065 13.9 5.4 4.4 8.2 0.3 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_16 PF13432.6 CCF48650.1 - 0.11 13.2 5.4 1 10.1 0.0 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_1 PF00515.28 CCF48650.1 - 0.14 12.1 0.2 2.3 8.2 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat RNase_PH PF01138.21 CCF48651.1 - 8.8e-33 113.6 0.0 1.5e-32 112.9 0.0 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 MS_channel PF00924.18 CCF48652.1 - 3.5e-20 72.4 0.5 5.2e-20 71.9 0.5 1.2 1 0 0 1 1 1 1 Mechanosensitive ion channel EF-hand_1 PF00036.32 CCF48652.1 - 0.0003 20.1 0.2 0.00065 19.1 0.2 1.6 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 CCF48652.1 - 0.0007 19.3 0.1 0.002 17.9 0.1 1.8 1 0 0 1 1 1 1 EF-hand domain EF-hand_5 PF13202.6 CCF48652.1 - 0.0029 17.0 0.2 0.006 16.0 0.2 1.5 1 0 0 1 1 1 1 EF hand EF-hand_8 PF13833.6 CCF48652.1 - 0.038 13.8 0.1 0.086 12.7 0.1 1.5 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_7 PF13499.6 CCF48652.1 - 0.095 13.2 0.1 0.23 11.9 0.1 1.6 1 0 0 1 1 1 0 EF-hand domain pair Ino80_Iec3 PF14612.6 CCF48652.1 - 0.18 12.4 0.1 14 6.3 0.1 2.3 2 0 0 2 2 2 0 IEC3 subunit of the Ino80 complex, chromatin re-modelling TMIE PF16038.5 CCF48652.1 - 1.4 8.8 4.1 1.5 8.7 0.6 2.5 2 0 0 2 2 2 0 TMIE protein Cyclin_N PF00134.23 CCF48653.1 - 2.6e-08 33.6 0.1 5.3e-07 29.4 0.0 2.5 2 1 0 2 2 2 1 Cyclin, N-terminal domain TFIIB PF00382.19 CCF48653.1 - 0.008 16.2 0.0 0.41 10.7 0.0 2.8 2 1 0 2 2 2 1 Transcription factor TFIIB repeat Cyclin_C_2 PF16899.5 CCF48653.1 - 0.11 12.8 0.4 0.51 10.7 0.0 2.2 2 0 0 2 2 2 0 Cyclin C-terminal domain Bax1-I PF01027.20 CCF48654.1 - 1.4e-35 123.1 8.3 2.3e-35 122.3 8.3 1.3 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 HEAT_EZ PF13513.6 CCF48655.1 - 7.4e-29 99.8 10.6 6.3e-06 26.6 0.0 10.7 12 0 0 12 12 10 5 HEAT-like repeat HEAT_2 PF13646.6 CCF48655.1 - 1.2e-20 73.7 5.9 0.00054 20.3 0.0 8.5 7 2 2 9 9 8 6 HEAT repeats HEAT PF02985.22 CCF48655.1 - 3.7e-17 60.9 18.9 0.0057 16.8 0.1 11.6 14 0 0 14 14 11 3 HEAT repeat UME PF08064.13 CCF48655.1 - 9.2e-14 51.2 2.6 0.046 13.6 0.0 7.0 6 1 1 7 7 7 3 UME (NUC010) domain Cnd1 PF12717.7 CCF48655.1 - 4.2e-12 46.4 0.8 0.0064 16.6 0.0 5.5 4 1 0 4 4 4 2 non-SMC mitotic condensation complex subunit 1 MMS19_C PF12460.8 CCF48655.1 - 1.1e-10 41.2 0.2 0.096 11.8 0.2 6.8 6 3 1 7 7 7 2 RNAPII transcription regulator C-terminal Vac14_Fab1_bd PF12755.7 CCF48655.1 - 2.7e-09 37.5 0.0 0.014 16.0 0.0 5.9 7 0 0 7 7 6 2 Vacuolar 14 Fab1-binding region Adaptin_N PF01602.20 CCF48655.1 - 1.1e-08 34.1 2.3 0.018 13.6 0.0 4.2 3 1 0 3 3 3 3 Adaptin N terminal region IBN_N PF03810.19 CCF48655.1 - 1.5e-06 28.0 0.1 8.1e-06 25.7 0.0 2.4 2 0 0 2 2 2 1 Importin-beta N-terminal domain CLASP_N PF12348.8 CCF48655.1 - 1.1e-05 25.1 0.0 0.94 9.0 0.0 5.0 4 1 0 4 4 4 1 CLASP N terminal MMS19_N PF14500.6 CCF48655.1 - 1.6e-05 24.7 1.4 0.081 12.5 0.1 5.0 4 1 0 4 4 4 1 Dos2-interacting transcription regulator of RNA-Pol-II Xpo1 PF08389.12 CCF48655.1 - 2e-05 24.7 4.9 0.078 13.0 0.1 5.9 5 1 0 5 5 5 1 Exportin 1-like protein IFRD PF05004.13 CCF48655.1 - 2.9e-05 23.4 0.2 0.21 10.7 0.0 3.9 3 1 0 3 3 3 1 Interferon-related developmental regulator (IFRD) Cohesin_HEAT PF12765.7 CCF48655.1 - 0.00071 19.8 0.7 1.2 9.5 0.1 3.5 3 0 0 3 3 3 1 HEAT repeat associated with sister chromatid cohesion Ipi1_N PF12333.8 CCF48655.1 - 0.00082 19.9 0.8 4.7 7.9 0.0 5.0 4 1 1 5 5 5 1 Rix1 complex component involved in 60S ribosome maturation RTP1_C1 PF10363.9 CCF48655.1 - 0.0012 19.0 0.9 60 3.9 0.0 5.0 4 0 0 4 4 4 0 Required for nuclear transport of RNA pol II C-terminus 1 RIX1 PF08167.12 CCF48655.1 - 0.0019 18.0 0.5 6.2 6.5 0.0 4.7 4 2 0 4 4 4 1 rRNA processing/ribosome biogenesis BP28CT PF08146.12 CCF48655.1 - 0.0031 17.4 0.0 1.9 8.3 0.0 4.0 4 0 0 4 4 3 1 BP28CT (NUC211) domain CAS_CSE1 PF03378.15 CCF48655.1 - 0.0035 15.9 0.6 0.98 7.8 0.0 4.0 5 0 0 5 5 5 1 CAS/CSE protein, C-terminus DUF3385 PF11865.8 CCF48655.1 - 0.0044 16.9 7.9 98 2.8 0.0 7.4 8 1 0 8 8 8 0 Domain of unknown function (DUF3385) Cnd3 PF12719.7 CCF48655.1 - 0.024 13.9 7.9 0.88 8.7 0.8 5.0 4 3 1 5 5 5 0 Nuclear condensing complex subunits, C-term domain DUF3437 PF11919.8 CCF48655.1 - 0.035 14.0 2.4 0.95 9.4 0.1 4.5 6 0 0 6 6 5 0 Domain of unknown function (DUF3437) Dopey_N PF04118.14 CCF48655.1 - 0.04 13.0 0.0 4.6 6.3 0.0 3.2 2 1 1 3 3 3 0 Dopey, N-terminal DRIM PF07539.12 CCF48655.1 - 0.053 11.8 2.5 10 4.3 0.1 4.4 3 1 1 4 4 4 0 Down-regulated in metastasis F-box_5 PF18511.1 CCF48655.1 - 0.2 11.2 0.1 1.7 8.2 0.1 2.3 2 0 0 2 2 2 0 F-box EF-hand_6 PF13405.6 CCF48655.1 - 0.35 10.9 1.3 1.3 9.2 1.3 2.0 1 0 0 1 1 1 0 EF-hand domain Myosin_head PF00063.21 CCF48656.1 - 6e-262 870.8 0.3 1.5e-261 869.5 0.0 1.7 2 0 0 2 2 2 1 Myosin head (motor domain) DIL PF01843.19 CCF48656.1 - 2.4e-27 95.3 0.9 2.4e-27 95.3 0.9 3.1 4 0 0 4 4 4 1 DIL domain IQ PF00612.27 CCF48656.1 - 4.5e-17 60.2 35.6 8.4e-05 22.0 0.2 6.8 6 0 0 6 6 6 6 IQ calmodulin-binding motif CALCOCO1 PF07888.11 CCF48656.1 - 0.0073 15.2 20.1 0.013 14.4 20.1 1.2 1 0 0 1 1 1 1 Calcium binding and coiled-coil domain (CALCOCO1) like AAA_22 PF13401.6 CCF48656.1 - 0.012 15.9 0.0 0.042 14.1 0.0 2.0 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 CCF48656.1 - 0.22 11.9 1.4 0.89 9.9 0.0 2.6 2 1 0 2 2 2 0 AAA ATPase domain DUF848 PF05852.11 CCF48656.1 - 0.51 10.5 24.9 3.2 7.9 4.8 4.1 3 1 1 4 4 4 0 Gammaherpesvirus protein of unknown function (DUF848) Med9 PF07544.13 CCF48656.1 - 1.5 8.9 10.7 4 7.6 1.2 3.3 2 1 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 DUF1192 PF06698.11 CCF48656.1 - 2.2 8.4 12.8 0.1 12.6 2.7 3.5 4 0 0 4 4 4 0 Protein of unknown function (DUF1192) BLOC1_2 PF10046.9 CCF48656.1 - 6.7 7.1 10.6 1.2 9.5 2.1 3.0 1 1 2 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 NPV_P10 PF05531.12 CCF48656.1 - 6.7 7.2 8.2 17 5.9 0.3 3.6 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein YabA PF06156.13 CCF48656.1 - 8 7.2 9.8 4.7 7.9 1.8 2.9 2 0 0 2 2 2 0 Initiation control protein YabA ubiquitin PF00240.23 CCF48657.1 - 1.8e-69 229.4 4.6 4.6e-34 116.0 0.3 2.2 2 0 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.8 CCF48657.1 - 7.3e-33 112.2 5.7 4.9e-16 58.3 0.4 2.2 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 CCF48657.1 - 2.8e-12 46.9 0.9 0.00014 22.2 0.1 3.2 2 2 0 2 2 2 2 Ubiquitin-like domain zf-AN1 PF01428.16 CCF48657.1 - 3.9e-10 39.7 4.9 6.5e-10 39.0 4.9 1.3 1 0 0 1 1 1 1 AN1-like Zinc finger TBK1_ULD PF18396.1 CCF48657.1 - 9.2e-08 31.9 0.2 0.015 15.2 0.0 2.3 2 0 0 2 2 2 2 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_5 PF18037.1 CCF48657.1 - 1.9e-07 31.4 0.2 0.025 14.9 0.0 2.3 1 1 0 2 2 2 2 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 CCF48657.1 - 2.1e-07 31.0 0.2 0.029 14.4 0.0 2.8 2 2 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 CCF48657.1 - 8.1e-06 26.3 0.1 0.077 13.6 0.0 2.3 1 1 1 2 2 2 2 DUF2407 ubiquitin-like domain Sde2_N_Ubi PF13019.6 CCF48657.1 - 0.00066 19.5 0.0 0.66 9.8 0.0 2.3 1 1 1 2 2 2 2 Silencing defective 2 N-terminal ubiquitin domain Methyltrans_RNA PF04452.14 CCF48657.1 - 0.0026 17.1 0.3 0.63 9.3 0.0 2.6 2 1 1 3 3 3 2 RNA methyltransferase Ubiquitin_4 PF18036.1 CCF48657.1 - 0.0067 16.4 11.7 10 6.2 0.2 4.5 5 0 0 5 5 5 1 Ubiquitin-like domain DUF2870 PF11069.8 CCF48657.1 - 0.033 14.6 0.0 17 5.9 0.0 2.8 2 2 0 2 2 2 0 Protein of unknown function (DUF2870) DUF3861 PF12977.7 CCF48657.1 - 0.066 13.4 0.1 8.3 6.6 0.0 2.4 2 0 0 2 2 2 0 Domain of Unknown Function with PDB structure (DUF3861) TmoB PF06234.12 CCF48657.1 - 0.074 13.1 0.7 19 5.4 0.1 2.8 2 2 0 2 2 2 0 Toluene-4-monooxygenase system protein B (TmoB) FlgD_ig PF13860.6 CCF48657.1 - 0.14 12.0 0.9 17 5.4 0.1 2.4 2 0 0 2 2 2 0 FlgD Ig-like domain Big_7 PF17957.1 CCF48657.1 - 0.14 12.9 0.0 19 6.1 0.0 2.2 2 0 0 2 2 2 0 Bacterial Ig domain Tash_PEST PF07708.11 CCF48657.1 - 7.3 6.9 6.8 4.4 7.6 1.5 2.3 2 0 0 2 2 2 0 Tash protein PEST motif HsbA PF12296.8 CCF48658.1 - 8.2e-25 87.6 13.4 8.2e-25 87.6 13.4 1.7 1 1 1 2 2 2 1 Hydrophobic surface binding protein A FTA4 PF13093.6 CCF48658.1 - 0.079 12.8 0.0 0.086 12.7 0.0 1.2 1 0 0 1 1 1 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 NPV_P10 PF05531.12 CCF48658.1 - 0.56 10.7 7.9 9.7 6.7 4.5 3.0 1 1 2 3 3 3 0 Nucleopolyhedrovirus P10 protein SMC_Nse1 PF07574.13 CCF48659.1 - 1.9e-29 102.9 1.0 2.4e-28 99.4 1.0 2.2 1 1 0 1 1 1 1 Nse1 non-SMC component of SMC5-6 complex zf-RING-like PF08746.11 CCF48659.1 - 9.1e-06 25.9 7.0 2.9e-05 24.3 6.8 1.9 1 1 1 2 2 2 1 RING-like domain zf-HC5HC2H PF13771.6 CCF48659.1 - 0.0011 19.1 0.9 0.0021 18.3 0.9 1.6 1 0 0 1 1 1 1 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.6 CCF48659.1 - 0.0014 18.7 0.1 0.0029 17.8 0.1 1.5 1 0 0 1 1 1 1 PHD-zinc-finger like domain PHD PF00628.29 CCF48659.1 - 0.039 13.9 3.2 0.11 12.4 3.1 1.9 1 1 0 1 1 1 0 PHD-finger NOA36 PF06524.12 CCF48659.1 - 0.35 10.1 13.3 0.017 14.5 7.3 1.8 2 0 0 2 2 2 0 NOA36 protein FRG2 PF15315.6 CCF48659.1 - 3 8.0 14.5 7 6.8 14.5 1.6 1 0 0 1 1 1 0 Facioscapulohumeral muscular dystrophy candidate 2 DUF4820 PF16091.5 CCF48659.1 - 3.7 6.8 13.3 0.23 10.8 6.5 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4820) Sugar_tr PF00083.24 CCF48660.1 - 4.9e-82 276.2 16.9 5.8e-82 275.9 16.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF48660.1 - 1e-16 60.8 47.9 1.7e-15 56.8 17.4 2.4 1 1 0 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 CCF48660.1 - 0.084 11.1 11.8 0.053 11.8 0.5 3.1 2 1 0 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family Motilin_ghrelin PF04644.12 CCF48661.1 - 4 7.3 8.3 8 6.4 8.3 1.5 1 0 0 1 1 1 0 Motilin/ghrelin PfkB PF00294.24 CCF48662.1 - 2.2e-39 135.6 0.0 2.8e-39 135.2 0.0 1.1 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Aminotran_1_2 PF00155.21 CCF48663.1 - 3.4e-87 293.0 0.1 3.9e-87 292.8 0.1 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II efThoc1 PF11957.8 CCF48664.1 - 4e-92 309.4 1.7 6.6e-41 140.5 0.0 3.3 2 1 1 3 3 3 3 THO complex subunit 1 transcription elongation factor CobN-Mg_chel PF02514.16 CCF48664.1 - 0.013 13.3 1.6 0.019 12.7 1.6 1.1 1 0 0 1 1 1 0 CobN/Magnesium Chelatase RRM_1 PF00076.22 CCF48665.1 - 7.3e-06 25.7 0.3 1.3e-05 25.0 0.1 1.5 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RPN7 PF10602.9 CCF48666.1 - 1.1e-50 171.8 1.0 1.1e-50 171.8 1.0 1.7 2 0 0 2 2 2 1 26S proteasome subunit RPN7 PCI PF01399.27 CCF48666.1 - 1.5e-15 57.6 0.0 4.7e-15 56.0 0.0 1.9 1 0 0 1 1 1 1 PCI domain Pribosyltran PF00156.27 CCF48667.1 - 1.1e-16 60.8 0.1 1.4e-16 60.5 0.1 1.1 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 CCF48667.1 - 0.0038 16.7 0.0 0.0054 16.2 0.0 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase SHR3_chaperone PF08229.11 CCF48670.1 - 8.8e-45 152.0 0.0 1.1e-44 151.7 0.0 1.0 1 0 0 1 1 1 1 ER membrane protein SH3 SecG PF03840.14 CCF48670.1 - 0.039 14.0 0.1 0.099 12.7 0.1 1.7 1 0 0 1 1 1 0 Preprotein translocase SecG subunit COBRA PF04833.15 CCF48671.1 - 0.11 12.4 0.1 12 5.8 0.0 2.3 2 0 0 2 2 2 0 COBRA-like protein UQ_con PF00179.26 CCF48672.1 - 2.6e-21 75.7 0.0 2.9e-21 75.6 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 CCF48672.1 - 0.016 15.5 0.0 0.017 15.4 0.0 1.2 1 0 0 1 1 1 0 RWD domain An_peroxidase PF03098.15 CCF48673.1 - 3.1e-44 151.5 0.0 1.1e-29 103.5 0.0 3.3 1 1 1 2 2 2 2 Animal haem peroxidase DUF883 PF05957.13 CCF48673.1 - 0.012 16.2 3.2 0.031 14.9 3.2 1.6 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF883) p450 PF00067.22 CCF48673.1 - 0.019 13.7 0.1 0.056 12.2 0.0 1.8 2 0 0 2 2 2 0 Cytochrome P450 ApoLp-III PF07464.11 CCF48673.1 - 0.24 11.5 5.2 0.5 10.5 5.2 1.6 1 0 0 1 1 1 0 Apolipophorin-III precursor (apoLp-III) zf-HIT PF04438.16 CCF48674.1 - 7.1e-10 38.6 14.3 1.8e-09 37.3 9.3 2.5 2 0 0 2 2 2 1 HIT zinc finger zf-B_box PF00643.24 CCF48674.1 - 0.081 13.1 5.0 0.17 12.1 5.0 1.5 1 0 0 1 1 1 0 B-box zinc finger Get5_C PF18514.1 CCF48674.1 - 0.16 11.7 0.3 1.6 8.5 0.0 2.5 2 0 0 2 2 2 0 Get5 C-terminal domain Gar1 PF04410.14 CCF48675.1 - 5.1e-37 127.0 0.0 6.1e-37 126.8 0.0 1.0 1 0 0 1 1 1 1 Gar1/Naf1 RNA binding region OPT PF03169.15 CCF48676.1 - 1.3e-141 473.3 36.9 1.5e-141 473.1 36.9 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein PrgI PF12666.7 CCF48676.1 - 0.25 12.1 0.1 0.25 12.1 0.1 5.2 4 1 1 5 5 5 0 PrgI family protein DUF1453 PF07301.11 CCF48676.1 - 0.37 10.8 4.9 0.19 11.7 0.7 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF1453) TP2 PF01254.18 CCF48677.1 - 0.17 12.5 6.2 0.16 12.6 4.6 1.7 1 1 1 2 2 2 0 Nuclear transition protein 2 DnaJ PF00226.31 CCF48678.1 - 1.2e-22 79.7 0.2 1.8e-22 79.2 0.2 1.3 1 0 0 1 1 1 1 DnaJ domain SSF PF00474.17 CCF48679.1 - 1.2e-16 60.7 27.9 1.6e-16 60.2 27.9 1.2 1 0 0 1 1 1 1 Sodium:solute symporter family Actin PF00022.19 CCF48680.1 - 1.6e-21 76.4 0.0 3.8e-11 42.3 0.0 3.1 3 0 0 3 3 3 3 Actin Actin_micro PF17003.5 CCF48680.1 - 2e-05 23.9 0.0 0.2 10.8 0.0 2.4 2 0 0 2 2 2 2 Putative actin-like family TPR_14 PF13428.6 CCF48681.1 - 5.5e-05 23.7 0.1 7.8 7.6 0.0 4.0 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_19 PF14559.6 CCF48681.1 - 0.00091 19.7 3.9 0.11 13.0 0.1 3.4 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_6 PF13174.6 CCF48681.1 - 0.0013 19.2 0.1 1.8 9.4 0.0 4.2 4 0 0 4 4 4 1 Tetratricopeptide repeat Clat_adaptor_s PF01217.20 CCF48682.1 - 2.9e-56 189.4 2.4 3.2e-56 189.2 2.4 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain TPR_2 PF07719.17 CCF48683.1 - 6.1e-07 29.1 1.9 0.034 14.2 0.2 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 CCF48683.1 - 1.4e-05 24.7 1.1 0.18 11.6 0.1 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 CCF48683.1 - 0.0021 18.7 3.6 0.22 12.4 0.6 2.6 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_9 PF13371.6 CCF48683.1 - 0.025 14.7 1.8 1.1 9.5 0.1 2.7 1 1 2 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.6 CCF48683.1 - 0.031 14.5 0.2 1.3 9.5 0.0 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_12 PF13424.6 CCF48683.1 - 0.078 13.3 1.9 0.39 11.0 0.1 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_16 PF13432.6 CCF48683.1 - 0.095 13.4 2.9 0.87 10.3 0.3 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF3824 PF12868.7 CCF48683.1 - 0.29 11.8 0.0 0.29 11.8 0.0 2.2 2 0 0 2 2 2 0 Domain of unknwon function (DUF3824) NADH-u_ox-rdase PF10785.9 CCF48684.1 - 1.1e-31 109.4 0.3 1.4e-31 109.0 0.3 1.2 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase complex I, 21 kDa subunit NADH_u_ox_C PF12853.7 CCF48684.1 - 1.7e-11 44.0 0.0 2.8e-11 43.2 0.0 1.3 1 0 0 1 1 1 1 C-terminal of NADH-ubiquinone oxidoreductase 21 kDa subunit tRNA-synt_2 PF00152.20 CCF48685.1 - 4.2e-73 246.2 0.0 5.9e-73 245.7 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) Neugrin PF06413.11 CCF48685.1 - 2.3e-09 37.6 1.2 6.3e-09 36.2 1.2 1.8 1 0 0 1 1 1 1 Neugrin RsfS PF02410.15 CCF48685.1 - 2.8e-07 30.9 0.0 1.3e-06 28.7 0.1 2.2 2 0 0 2 2 2 1 Ribosomal silencing factor during starvation tRNA_anti-codon PF01336.25 CCF48685.1 - 1.4e-05 25.0 0.0 2.7e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain MRP-L20 PF12824.7 CCF48685.1 - 0.00067 19.8 0.1 0.0017 18.5 0.1 1.7 1 0 0 1 1 1 1 Mitochondrial ribosomal protein subunit L20 PseudoU_synth_1 PF01416.20 CCF48686.1 - 3.2e-23 82.3 0.0 7e-19 68.3 0.0 3.3 3 0 0 3 3 3 2 tRNA pseudouridine synthase Peptidase_C97 PF05903.14 CCF48687.1 - 1.4e-37 128.8 0.0 7.4e-37 126.5 0.0 2.0 2 0 0 2 2 2 1 PPPDE putative peptidase domain PUL PF08324.11 CCF48687.1 - 2.9e-31 108.7 5.1 4.2e-31 108.2 5.1 1.2 1 0 0 1 1 1 1 PUL domain Thioredoxin PF00085.20 CCF48687.1 - 9.3e-08 32.0 0.0 2.4e-07 30.7 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin OST3_OST6 PF04756.13 CCF48687.1 - 0.00014 21.4 0.0 0.00022 20.7 0.0 1.2 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family PITH PF06201.13 CCF48688.1 - 2.9e-32 112.0 0.0 5.3e-32 111.1 0.0 1.4 1 0 0 1 1 1 1 PITH domain Thioredoxin PF00085.20 CCF48688.1 - 4.4e-24 84.4 0.0 8.3e-24 83.5 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_9 PF14595.6 CCF48688.1 - 0.00021 21.1 0.0 0.00059 19.6 0.0 1.8 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 CCF48688.1 - 0.0004 20.8 0.1 0.0022 18.4 0.1 2.2 1 1 0 1 1 1 1 Thioredoxin-like domain OST3_OST6 PF04756.13 CCF48688.1 - 0.00044 19.7 0.0 0.00079 18.9 0.0 1.3 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_8 PF13905.6 CCF48688.1 - 0.0073 16.6 0.0 0.054 13.8 0.0 2.3 1 1 0 1 1 1 1 Thioredoxin-like Thioredoxin_7 PF13899.6 CCF48688.1 - 0.025 14.8 0.1 0.059 13.6 0.1 1.6 1 0 0 1 1 1 0 Thioredoxin-like HyaE PF07449.11 CCF48688.1 - 0.041 13.8 0.0 0.097 12.6 0.0 1.6 1 0 0 1 1 1 0 Hydrogenase-1 expression protein HyaE HLH PF00010.26 CCF48689.1 - 1.8e-08 34.2 1.7 4.8e-08 32.8 0.9 2.2 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain ASD2 PF08687.11 CCF48689.1 - 3.4 7.1 7.0 0.73 9.3 3.0 1.7 2 0 0 2 2 2 0 Apx/Shroom domain ASD2 RhoGAP PF00620.27 CCF48690.1 - 9.1e-48 161.9 0.0 1.6e-47 161.1 0.0 1.4 1 0 0 1 1 1 1 RhoGAP domain FCH PF00611.23 CCF48690.1 - 1.2e-13 51.1 1.7 3.1e-13 49.8 0.4 2.2 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain BAR PF03114.18 CCF48690.1 - 0.069 12.8 2.0 0.16 11.6 2.0 1.5 1 0 0 1 1 1 0 BAR domain PspA_IM30 PF04012.12 CCF48690.1 - 0.11 12.1 4.6 0.062 12.9 1.8 2.0 2 0 0 2 2 2 0 PspA/IM30 family CENP-H PF05837.12 CCF48690.1 - 0.14 12.6 1.0 0.44 11.0 1.0 1.8 1 0 0 1 1 1 0 Centromere protein H (CENP-H) Pkinase PF00069.25 CCF48691.1 - 1.2e-71 241.2 0.0 1.5e-71 240.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF48691.1 - 6.7e-47 160.0 0.0 9.8e-47 159.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.28 CCF48691.1 - 3.1e-23 81.9 0.1 8e-23 80.6 0.1 1.8 1 0 0 1 1 1 1 P21-Rho-binding domain Pkinase_fungal PF17667.1 CCF48691.1 - 1.5e-06 27.3 0.0 2.9e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 CCF48691.1 - 2.3e-05 23.9 0.0 3.8e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 CCF48691.1 - 0.0048 16.3 0.1 0.18 11.1 0.0 2.3 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family DSHCT PF08148.12 CCF48691.1 - 0.021 14.5 0.0 0.039 13.6 0.0 1.4 1 0 0 1 1 1 0 DSHCT (NUC185) domain APH PF01636.23 CCF48691.1 - 0.027 14.4 0.2 0.27 11.1 0.3 2.2 1 1 1 2 2 2 0 Phosphotransferase enzyme family Macoilin PF09726.9 CCF48691.1 - 0.089 11.3 5.1 0.16 10.5 5.1 1.3 1 0 0 1 1 1 0 Macoilin family DUF2810 PF10928.8 CCF48693.1 - 0.055 13.5 0.0 0.098 12.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2810) Trp_syntA PF00290.20 CCF48694.1 - 2.2e-88 295.5 0.3 3.9e-88 294.6 0.3 1.4 1 0 0 1 1 1 1 Tryptophan synthase alpha chain PALP PF00291.25 CCF48694.1 - 4.8e-48 164.1 0.2 1.2e-47 162.8 0.2 1.7 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme His_biosynth PF00977.21 CCF48694.1 - 0.0033 16.9 0.3 0.014 14.8 0.1 2.0 2 0 0 2 2 2 1 Histidine biosynthesis protein Rad9 PF04139.13 CCF48695.1 - 3.7e-46 157.6 0.0 4.5e-46 157.3 0.0 1.1 1 0 0 1 1 1 1 Rad9 RINGv PF12906.7 CCF48696.1 - 2.9e-14 52.9 9.2 5.1e-14 52.1 9.2 1.4 1 0 0 1 1 1 1 RING-variant domain zf-RING_2 PF13639.6 CCF48696.1 - 0.16 12.3 10.8 0.3 11.4 10.8 1.5 1 0 0 1 1 1 0 Ring finger domain zf-ANAPC11 PF12861.7 CCF48696.1 - 3.7 7.7 6.1 8.7 6.5 6.1 1.7 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger DEAD PF00270.29 CCF48697.1 - 4.4e-44 150.3 0.0 2e-43 148.2 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CCF48697.1 - 7.9e-27 93.8 0.0 7e-26 90.7 0.0 2.6 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 CCF48697.1 - 8.5e-05 22.6 0.0 0.00025 21.1 0.0 1.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit zf-CCHC PF00098.23 CCF48697.1 - 0.012 15.7 1.2 0.021 14.9 1.2 1.4 1 0 0 1 1 1 0 Zinc knuckle ERCC3_RAD25_C PF16203.5 CCF48697.1 - 0.013 14.7 0.1 0.03 13.5 0.1 1.5 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase zf-CCHC_4 PF14392.6 CCF48697.1 - 0.055 13.2 0.3 0.12 12.1 0.3 1.6 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_2 PF13696.6 CCF48697.1 - 0.081 12.8 2.5 0.19 11.6 2.5 1.6 1 0 0 1 1 1 0 Zinc knuckle Phage_endo_I PF05367.11 CCF48697.1 - 0.11 12.1 0.0 0.29 10.7 0.0 1.7 1 0 0 1 1 1 0 Phage endonuclease I ubiquitin PF00240.23 CCF48698.1 - 2.1e-34 117.1 0.5 3.4e-34 116.4 0.5 1.3 1 0 0 1 1 1 1 Ubiquitin family Ribosomal_S27 PF01599.19 CCF48698.1 - 5.9e-26 90.4 1.0 1.2e-25 89.4 1.0 1.5 1 0 0 1 1 1 1 Ribosomal protein S27a Rad60-SLD PF11976.8 CCF48698.1 - 3.9e-16 58.6 0.6 7.9e-16 57.7 0.6 1.5 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 CCF48698.1 - 3e-05 24.4 0.1 0.00014 22.2 0.1 2.0 1 1 0 1 1 1 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 CCF48698.1 - 0.0011 19.1 0.2 0.0025 17.9 0.2 1.6 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like IBR PF01485.21 CCF48698.1 - 0.0033 17.6 0.3 0.0055 16.9 0.3 1.4 1 0 0 1 1 1 1 IBR domain, a half RING-finger domain Ubiquitin_5 PF18037.1 CCF48698.1 - 0.0062 16.9 0.2 0.012 15.9 0.0 1.5 1 1 0 1 1 1 1 Ubiquitin-like domain TBK1_ULD PF18396.1 CCF48698.1 - 0.0073 16.2 0.0 0.011 15.7 0.0 1.3 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain DUF2407 PF10302.9 CCF48698.1 - 0.018 15.6 0.4 0.025 15.1 0.4 1.2 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain Ubiquitin_4 PF18036.1 CCF48698.1 - 0.024 14.7 1.1 5.9 7.0 0.2 2.3 2 0 0 2 2 2 0 Ubiquitin-like domain Med4 PF10018.9 CCF48699.1 - 9.2e-24 84.2 3.8 1.8e-23 83.2 3.8 1.5 1 0 0 1 1 1 1 Vitamin-D-receptor interacting Mediator subunit 4 APG6_N PF17675.1 CCF48699.1 - 3 8.4 10.7 0.33 11.5 5.7 2.0 2 0 0 2 2 2 0 Apg6 coiled-coil region G-patch PF01585.23 CCF48700.1 - 3e-05 23.8 0.1 3e-05 23.8 0.1 2.2 2 0 0 2 2 2 1 G-patch domain CDP-OH_P_transf PF01066.21 CCF48701.1 - 1.6e-13 51.2 0.7 4.2e-13 49.8 0.2 2.0 2 0 0 2 2 2 1 CDP-alcohol phosphatidyltransferase UCH_1 PF13423.6 CCF48702.1 - 5.6e-91 305.5 0.0 7.9e-91 305.0 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase RNase_T PF00929.24 CCF48702.1 - 2.7e-18 67.1 0.1 2.9e-17 63.7 0.0 2.5 3 0 0 3 3 3 1 Exonuclease WD40 PF00400.32 CCF48702.1 - 0.0026 18.6 0.1 0.11 13.4 0.0 3.3 3 0 0 3 3 3 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF48702.1 - 0.014 15.7 0.0 2 8.7 0.0 2.6 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain UCH PF00443.29 CCF48702.1 - 0.067 12.7 0.0 1.1 8.7 0.1 2.2 2 0 0 2 2 2 0 Ubiquitin carboxyl-terminal hydrolase zf-BED PF02892.15 CCF48702.1 - 0.14 12.2 0.2 0.65 10.1 0.0 2.2 2 0 0 2 2 2 0 BED zinc finger Fungal_trans PF04082.18 CCF48703.1 - 0.00083 18.5 0.0 0.0019 17.3 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain ODAPH PF15848.5 CCF48703.1 - 0.13 12.7 0.0 0.29 11.6 0.0 1.5 1 0 0 1 1 1 0 Odontogenesis associated phosphoprotein Q_salvage PF10343.9 CCF48704.1 - 2.6e-10 40.4 0.0 2.1e-06 27.5 0.0 2.2 2 0 0 2 2 2 2 Potential Queuosine, Q, salvage protein family RVT_2 PF07727.14 CCF48705.1 - 1.7e-44 152.3 0.0 5.1e-44 150.7 0.0 1.7 1 1 1 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 CCF48705.1 - 5.6e-09 36.2 0.1 1.2e-08 35.2 0.1 1.5 1 0 0 1 1 1 1 Integrase core domain Mitoc_mL59 PF18126.1 CCF48706.1 - 2.8e-24 85.9 9.0 6.6e-24 84.7 9.0 1.6 1 1 0 1 1 1 1 Mitochondrial ribosomal protein mL59 Tim44 PF04280.15 CCF48707.1 - 3e-30 105.3 0.0 6e-30 104.3 0.0 1.5 1 0 0 1 1 1 1 Tim44-like domain Pkinase PF00069.25 CCF48708.1 - 7.7e-52 176.2 0.0 1.1e-51 175.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF48708.1 - 1.7e-19 70.1 0.0 2.8e-19 69.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 CCF48708.1 - 0.0077 16.2 0.0 0.022 14.7 0.0 1.7 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.22 CCF48708.1 - 0.056 13.0 0.0 0.11 12.0 0.0 1.5 1 0 0 1 1 1 0 RIO1 family Choline_kinase PF01633.20 CCF48708.1 - 0.077 12.6 0.3 0.14 11.7 0.3 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase SUIM_assoc PF16619.5 CCF48708.1 - 0.25 11.4 12.2 0.0087 16.1 4.0 3.1 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 SAC3_GANP PF03399.16 CCF48710.1 - 3.6e-22 79.1 5.3 5.9e-20 71.8 5.3 2.2 1 1 0 1 1 1 1 SAC3/GANP family CSN8_PSD8_EIF3K PF10075.9 CCF48710.1 - 2.3e-05 24.4 1.8 2.8e-05 24.1 0.4 1.8 2 0 0 2 2 2 1 CSN8/PSMD8/EIF3K family COX5A PF02284.16 CCF48710.1 - 0.0038 17.2 0.0 0.012 15.6 0.0 1.8 1 0 0 1 1 1 1 Cytochrome c oxidase subunit Va DUF982 PF06169.12 CCF48710.1 - 0.018 15.1 0.2 9.5 6.3 0.1 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF982) BAG PF02179.16 CCF48711.1 - 3.8e-15 56.1 0.5 3.8e-15 56.1 0.5 1.5 2 0 0 2 2 2 1 BAG domain ubiquitin PF00240.23 CCF48711.1 - 9.5e-05 22.1 0.0 0.00021 21.0 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin family RHH_6 PF16762.5 CCF48711.1 - 0.012 16.2 0.8 0.033 14.8 0.8 1.7 1 0 0 1 1 1 0 Ribbon-helix-helix domain MGAT2 PF05060.14 CCF48711.1 - 0.059 12.4 0.1 0.099 11.7 0.1 1.3 1 0 0 1 1 1 0 N-acetylglucosaminyltransferase II (MGAT2) TarH PF02203.15 CCF48711.1 - 0.086 12.8 2.2 0.18 11.7 0.4 1.9 2 0 0 2 2 2 0 Tar ligand binding domain homologue PRR22 PF15776.5 CCF48711.1 - 0.2 11.0 0.2 0.3 10.4 0.2 1.2 1 0 0 1 1 1 0 Proline-rich protein family 22 GHMP_kinases_N PF00288.26 CCF48712.1 - 4.3e-11 42.9 0.0 1.2e-10 41.4 0.0 1.9 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 CCF48712.1 - 0.00013 22.2 0.0 0.00032 21.0 0.0 1.6 1 0 0 1 1 1 1 GHMP kinases C terminal WD40 PF00400.32 CCF48713.1 - 2.2e-11 44.1 13.6 0.072 14.0 0.0 7.5 8 1 0 8 8 8 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF48713.1 - 0.027 14.7 0.0 3.6 8.0 0.0 3.2 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain Hamartin PF04388.12 CCF48713.1 - 0.061 12.0 7.7 0.087 11.5 7.7 1.2 1 0 0 1 1 1 0 Hamartin protein Pol_alpha_B_N PF08418.10 CCF48713.1 - 0.4 10.6 2.5 0.94 9.4 2.5 1.6 1 0 0 1 1 1 0 DNA polymerase alpha subunit B N-terminal SR-25 PF10500.9 CCF48713.1 - 8.1 6.0 16.4 16 5.0 16.4 1.5 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein PRP38 PF03371.15 CCF48714.1 - 9.4e-55 185.2 0.0 1.2e-54 184.8 0.0 1.1 1 0 0 1 1 1 1 PRP38 family Ctr PF04145.15 CCF48715.1 - 1.7e-13 51.4 0.1 2.5e-13 50.9 0.1 1.3 1 0 0 1 1 1 1 Ctr copper transporter family HnRNPA1 PF11627.8 CCF48716.1 - 0.1 12.8 0.7 0.1 12.8 0.7 2.3 2 0 0 2 2 2 0 Nuclear factor hnRNPA1 AA_permease PF00324.21 CCF48717.1 - 6e-64 216.4 28.3 7.5e-64 216.1 28.3 1.1 1 0 0 1 1 1 1 Amino acid permease SLC12 PF03522.15 CCF48717.1 - 1.4e-17 63.9 6.0 1.8e-11 43.7 0.0 3.5 4 0 0 4 4 4 3 Solute carrier family 12 UPF0220 PF05255.11 CCF48717.1 - 0.08 12.5 0.3 0.59 9.7 1.2 2.0 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0220) Pkinase PF00069.25 CCF48718.1 - 1e-71 241.4 0.0 1.6e-71 240.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Abhydrolase_3 PF07859.13 CCF48718.1 - 4e-47 160.8 0.1 1.7e-46 158.7 0.0 2.1 2 0 0 2 2 2 1 alpha/beta hydrolase fold Pkinase_Tyr PF07714.17 CCF48718.1 - 1.9e-36 125.7 0.0 3e-36 125.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Say1_Mug180 PF10340.9 CCF48718.1 - 2e-12 46.7 0.0 6e-12 45.1 0.0 1.7 1 1 0 1 1 1 1 Steryl acetyl hydrolase YrbL-PhoP_reg PF10707.9 CCF48718.1 - 3.9e-05 23.3 0.0 8.2e-05 22.2 0.0 1.5 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL Kdo PF06293.14 CCF48718.1 - 0.0012 18.3 0.5 0.0025 17.2 0.1 1.7 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 CCF48718.1 - 0.025 13.9 0.0 0.26 10.6 0.0 2.2 2 0 0 2 2 2 0 Kinase-like RIO1 PF01163.22 CCF48718.1 - 0.14 11.7 0.7 0.28 10.8 0.1 1.7 2 0 0 2 2 2 0 RIO1 family Haspin_kinase PF12330.8 CCF48718.1 - 0.2 10.6 0.1 0.37 9.7 0.1 1.4 1 0 0 1 1 1 0 Haspin like kinase domain Pkinase_fungal PF17667.1 CCF48718.1 - 0.38 9.5 0.0 0.38 9.5 0.0 2.5 4 0 0 4 4 4 0 Fungal protein kinase ArAE_2_N PF10337.9 CCF48719.1 - 4.7e-63 213.9 5.6 8.5e-63 213.0 1.1 2.4 2 0 0 2 2 2 1 Putative ER transporter, 6TM, N-terminal ArAE_2 PF10334.9 CCF48719.1 - 1e-23 84.4 1.3 3.9e-13 49.8 0.0 3.7 4 0 0 4 4 4 2 Aromatic acid exporter family member 2 FUSC_2 PF13515.6 CCF48719.1 - 4.1e-07 30.2 19.6 4.1e-07 30.2 19.6 3.8 2 2 2 4 4 4 1 Fusaric acid resistance protein-like ALMT PF11744.8 CCF48719.1 - 0.0036 16.2 0.0 0.0089 14.9 0.0 1.6 1 0 0 1 1 1 1 Aluminium activated malate transporter DUF1736 PF08409.11 CCF48719.1 - 0.1 12.6 0.3 0.45 10.6 0.3 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1736) Translin PF01997.16 CCF48720.1 - 1.3e-59 201.6 0.3 1.8e-59 201.2 0.3 1.2 1 0 0 1 1 1 1 Translin family UNC45-central PF11701.8 CCF48723.1 - 9.1e-11 41.9 0.2 9.1e-11 41.9 0.2 3.2 2 1 1 3 3 3 1 Myosin-binding striated muscle assembly central RNA_pol_Rpb1_1 PF04997.12 CCF48724.1 - 1.3e-85 287.5 0.1 2.1e-85 286.8 0.1 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_5 PF04998.17 CCF48724.1 - 7.8e-83 278.0 0.7 1.1e-82 277.5 0.7 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 CCF48724.1 - 2.3e-72 242.6 0.0 4.2e-72 241.8 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.18 CCF48724.1 - 3e-37 128.0 0.0 8.7e-37 126.5 0.0 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.17 CCF48724.1 - 6.3e-31 106.5 0.0 1.5e-30 105.3 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 Tox-MPTase2 PF15638.6 CCF48724.1 - 0.02 14.6 0.0 0.066 12.9 0.0 1.8 1 0 0 1 1 1 0 Metallopeptidase toxin 2 DUF2225 PF09986.9 CCF48724.1 - 0.11 12.3 0.3 0.21 11.3 0.3 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2225) zinc_ribbon_15 PF17032.5 CCF48724.1 - 0.12 13.1 1.2 0.26 12.0 1.2 1.6 1 0 0 1 1 1 0 zinc-ribbon family zf-tcix PF14952.6 CCF48724.1 - 0.15 11.7 0.5 0.44 10.2 0.5 1.7 1 0 0 1 1 1 0 Putative treble-clef, zinc-finger, Zn-binding Spherulin4 PF12138.8 CCF48725.1 - 5.4e-74 248.8 2.4 6.9e-74 248.5 2.4 1.1 1 0 0 1 1 1 1 Spherulation-specific family 4 Sugar_tr PF00083.24 CCF48726.1 - 2e-72 244.5 28.3 8.1e-37 127.1 9.2 2.0 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 CCF48726.1 - 2e-11 43.5 36.0 2e-11 43.5 36.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Cyclase PF04199.13 CCF48727.1 - 6.7e-14 52.3 0.1 8.8e-14 51.9 0.1 1.2 1 0 0 1 1 1 1 Putative cyclase DUF4965 PF16335.5 CCF48728.1 - 2.5e-69 232.4 0.1 5.2e-69 231.4 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4965) DUF1793 PF08760.11 CCF48728.1 - 9e-63 211.7 0.1 2.1e-62 210.4 0.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1793) DUF5127 PF17168.4 CCF48728.1 - 2.3e-52 178.1 3.9 3.7e-52 177.3 3.9 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF5127) Glyco_hydr_116N PF12215.8 CCF48728.1 - 0.015 14.8 0.1 0.028 13.9 0.1 1.4 1 0 0 1 1 1 0 beta-glucosidase 2, glycosyl-hydrolase family 116 N-term DUF4964 PF16334.5 CCF48728.1 - 0.1 12.1 1.0 2.4 7.8 0.1 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4964) URO-D PF01208.17 CCF48729.1 - 2.6e-137 457.6 0.0 2.9e-137 457.4 0.0 1.0 1 0 0 1 1 1 1 Uroporphyrinogen decarboxylase (URO-D) HMG_box PF00505.19 CCF48730.1 - 3.5e-16 59.4 2.0 7.5e-16 58.3 2.0 1.6 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 CCF48730.1 - 9.5e-13 48.6 1.6 1.7e-12 47.7 1.6 1.4 1 0 0 1 1 1 1 HMG-box domain MCC-bdg_PDZ PF10506.9 CCF48730.1 - 0.013 15.5 0.1 0.027 14.5 0.1 1.5 1 0 0 1 1 1 0 PDZ domain of MCC-2 bdg protein for Usher syndrome CHDNT PF08073.12 CCF48730.1 - 0.017 15.1 0.1 0.078 13.0 0.0 2.0 2 0 0 2 2 2 0 CHDNT (NUC034) domain YABBY PF04690.13 CCF48730.1 - 0.084 13.4 3.8 0.045 14.3 1.1 2.2 1 1 1 2 2 2 0 YABBY protein zf-CCCH_4 PF18044.1 CCF48731.1 - 5.6e-06 26.0 7.7 8.6e-06 25.4 7.7 1.3 1 0 0 1 1 1 1 CCCH-type zinc finger zf_CCCH_4 PF18345.1 CCF48731.1 - 0.00031 20.7 8.2 0.0005 20.0 8.2 1.4 1 0 0 1 1 1 1 Zinc finger domain zf-CCCH_2 PF14608.6 CCF48731.1 - 0.0054 17.2 5.9 0.0082 16.6 5.9 1.3 1 0 0 1 1 1 1 RNA-binding, Nab2-type zinc finger zf-CCCH PF00642.24 CCF48731.1 - 0.0054 16.6 8.2 0.009 15.9 8.2 1.3 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Torus PF16131.5 CCF48731.1 - 0.012 16.3 0.7 0.012 16.3 0.7 2.6 3 0 0 3 3 3 0 Torus domain Med26 PF08711.11 CCF48731.1 - 0.084 12.9 0.1 0.21 11.7 0.1 1.7 1 0 0 1 1 1 0 TFIIS helical bundle-like domain zf-CCCH_3 PF15663.5 CCF48731.1 - 0.29 11.4 2.2 0.79 10.0 2.2 1.7 1 0 0 1 1 1 0 Zinc-finger containing family NTP_transf_6 PF06042.11 CCF48732.1 - 0.11 12.4 0.0 0.22 11.3 0.0 1.6 1 1 0 1 1 1 0 Nucleotidyltransferase DUF3461 PF11944.8 CCF48732.1 - 0.13 12.4 0.0 1.9 8.7 0.0 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF3461) Vfa1 PF08432.10 CCF48734.1 - 1.5e-32 113.4 0.0 2.7e-32 112.6 0.0 1.4 1 1 0 1 1 1 1 AAA-ATPase Vps4-associated protein 1 SLATT_1 PF18181.1 CCF48734.1 - 0.032 14.2 0.7 0.051 13.5 0.7 1.3 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain 1 XRN_M PF17846.1 CCF48735.1 - 5.5e-149 496.9 0.7 2.4e-105 353.1 0.1 2.5 1 1 1 2 2 2 2 Xrn1 helical domain XRN_N PF03159.18 CCF48735.1 - 2.4e-100 335.0 0.0 5.1e-100 333.9 0.0 1.6 1 0 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus zf-CCHC PF00098.23 CCF48735.1 - 0.00053 19.9 1.6 0.001 19.0 1.6 1.5 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_2 PF13696.6 CCF48735.1 - 0.028 14.2 0.9 0.053 13.4 0.9 1.4 1 0 0 1 1 1 0 Zinc knuckle PMI_typeI PF01238.21 CCF48737.1 - 5.4e-108 361.5 0.0 6.5e-108 361.3 0.0 1.0 1 0 0 1 1 1 1 Phosphomannose isomerase type I Cupin_2 PF07883.11 CCF48737.1 - 0.00057 19.5 0.1 0.22 11.3 0.1 2.5 2 0 0 2 2 2 2 Cupin domain Cupin_3 PF05899.12 CCF48737.1 - 0.039 13.6 0.2 0.095 12.4 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF861) Cupin_6 PF12852.7 CCF48737.1 - 0.089 12.5 0.0 0.63 9.7 0.0 2.1 2 0 0 2 2 2 0 Cupin DUF2834 PF11196.8 CCF48738.1 - 4.6e-10 39.7 17.2 0.00086 19.6 0.5 4.6 4 0 0 4 4 4 4 Protein of unknown function (DUF2834) Strabismus PF06638.11 CCF48738.1 - 0.16 10.6 0.5 0.35 9.5 0.5 1.5 1 0 0 1 1 1 0 Strabismus protein PVL_ORF50 PF07768.11 CCF48738.1 - 0.19 12.0 1.1 0.47 10.8 1.1 1.6 1 0 0 1 1 1 0 PVL ORF-50-like family CGI-121 PF08617.10 CCF48739.1 - 5e-50 169.8 0.0 7e-50 169.3 0.0 1.2 1 0 0 1 1 1 1 Kinase binding protein CGI-121 Alpha_Helical PF18489.1 CCF48739.1 - 0.11 12.7 0.0 0.18 12.0 0.0 1.4 1 0 0 1 1 1 0 Alpha helical domain NDUF_B7 PF05676.13 CCF48740.1 - 9.1e-29 99.0 3.4 1.1e-28 98.7 3.4 1.1 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) Cmc1 PF08583.10 CCF48740.1 - 0.001 19.0 1.9 0.001 19.0 1.9 1.6 1 1 1 2 2 2 1 Cytochrome c oxidase biogenesis protein Cmc1 like S36_mt PF10937.8 CCF48741.1 - 3.6e-11 44.7 1.1 4.3e-11 44.4 1.1 1.1 1 0 0 1 1 1 1 Ribosomal protein S36, mitochondrial P_C PF06640.11 CCF48741.1 - 0.051 13.7 0.1 0.063 13.4 0.1 1.1 1 0 0 1 1 1 0 P protein C-terminus DUF4211 PF13926.6 CCF48742.1 - 8.6e-09 35.6 0.7 7.3e-08 32.6 0.0 2.7 3 0 0 3 3 3 1 Domain of unknown function (DUF4211) DUF4778 PF16008.5 CCF48742.1 - 0.63 10.1 12.1 1.3 9.0 12.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4778) SR-25 PF10500.9 CCF48742.1 - 5.1 6.6 70.3 1.3 8.6 16.4 4.7 3 1 1 4 4 4 0 Nuclear RNA-splicing-associated protein SNARE PF05739.19 CCF48743.1 - 3.3e-11 43.0 0.6 3.3e-11 43.0 0.6 2.3 3 0 0 3 3 3 1 SNARE domain Syntaxin PF00804.25 CCF48743.1 - 0.00024 20.8 6.5 0.0012 18.5 0.1 2.2 2 0 0 2 2 2 2 Syntaxin PMT PF02366.18 CCF48744.1 - 4.4e-76 255.7 14.4 7.9e-76 254.9 14.4 1.4 1 0 0 1 1 1 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 CCF48744.1 - 8.4e-66 221.4 6.9 8.4e-66 221.4 6.9 2.2 3 0 0 3 3 3 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 CCF48744.1 - 1.1e-40 139.5 0.1 2.6e-40 138.3 0.1 1.6 1 0 0 1 1 1 1 MIR domain PMT_2 PF13231.6 CCF48744.1 - 0.00016 21.9 9.6 0.00016 21.9 9.6 3.4 3 0 0 3 3 3 1 Dolichyl-phosphate-mannose-protein mannosyltransferase Abhydro_lipase PF04083.16 CCF48745.1 - 1.5e-16 59.7 0.0 3.6e-16 58.5 0.0 1.7 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region Abhydrolase_1 PF00561.20 CCF48745.1 - 2.3e-09 37.3 0.1 6.4e-09 35.8 0.1 1.7 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CCF48745.1 - 0.00024 21.8 0.8 0.00045 20.9 0.8 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Sec63 PF02889.16 CCF48746.1 - 1.3e-19 70.4 0.0 4.9e-19 68.5 0.0 1.8 1 1 0 1 1 1 1 Sec63 Brl domain DnaJ PF00226.31 CCF48746.1 - 1.4e-14 54.0 0.3 3.4e-14 52.7 0.3 1.7 1 0 0 1 1 1 1 DnaJ domain PITH PF06201.13 CCF48747.1 - 8.5e-29 100.7 0.0 2.1e-28 99.5 0.0 1.7 2 0 0 2 2 2 1 PITH domain CENP-T_C PF15511.6 CCF48747.1 - 9.5e-11 41.8 0.6 3e-10 40.2 0.1 2.0 1 1 1 2 2 2 1 Centromere kinetochore component CENP-T histone fold MAM33 PF02330.16 CCF48750.1 - 6.1e-62 209.3 0.0 7.1e-62 209.1 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial glycoprotein DUF1889 PF08986.10 CCF48750.1 - 0.078 13.4 0.1 0.36 11.2 0.0 2.0 3 0 0 3 3 3 0 Domain of unknown function (DUF1889) RRM_1 PF00076.22 CCF48751.1 - 1.3e-13 50.5 0.0 3.7e-05 23.4 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SR-25 PF10500.9 CCF48751.1 - 0.0094 15.6 27.0 0.0094 15.6 27.0 3.5 4 1 0 4 4 4 2 Nuclear RNA-splicing-associated protein PI3K_1B_p101 PF10486.9 CCF48751.1 - 0.02 12.7 6.0 0.029 12.2 6.0 1.4 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit CSRNP_N PF16019.5 CCF48751.1 - 3.7 7.4 9.2 0.25 11.2 3.0 2.1 2 0 0 2 2 2 0 Cysteine/serine-rich nuclear protein N-terminus DUF3246 PF11596.8 CCF48751.1 - 4.8 6.5 16.8 0.039 13.4 3.7 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF3246) tRNA-synt_2b PF00587.25 CCF48752.1 - 5e-30 104.8 0.0 1.1e-29 103.7 0.0 1.6 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 CCF48752.1 - 0.0089 16.2 0.0 0.033 14.3 0.0 1.9 1 0 0 1 1 1 1 Anticodon binding domain Acyl-CoA_dh_1 PF00441.24 CCF48753.1 - 1.1e-42 145.8 6.9 1.2e-42 145.7 5.6 1.7 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 CCF48753.1 - 8.5e-27 94.1 0.8 3.2e-26 92.2 0.0 2.3 3 0 0 3 3 3 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 CCF48753.1 - 1.1e-22 80.0 0.1 2.4e-22 79.0 0.1 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 CCF48753.1 - 7.4e-21 74.8 2.5 1.8e-20 73.6 2.5 1.7 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Snf7 PF03357.21 CCF48753.1 - 0.0051 16.4 3.2 0.011 15.4 3.2 1.5 1 0 0 1 1 1 1 Snf7 Prefoldin_2 PF01920.20 CCF48753.1 - 0.035 14.1 0.8 2 8.4 0.3 2.4 2 0 0 2 2 2 0 Prefoldin subunit adh_short_C2 PF13561.6 CCF48754.1 - 1e-40 139.8 0.2 1.7e-39 135.8 0.0 2.0 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCF48754.1 - 4.5e-34 117.6 0.6 1.8e-28 99.3 0.1 2.1 2 0 0 2 2 2 2 short chain dehydrogenase KR PF08659.10 CCF48754.1 - 7.2e-05 22.8 0.1 0.00024 21.1 0.1 1.7 1 1 0 1 1 1 1 KR domain DSPn PF14671.6 CCF48755.1 - 3e-37 128.2 0.1 2.4e-35 122.0 0.1 2.3 2 0 0 2 2 2 1 Dual specificity protein phosphatase, N-terminal half DSPc PF00782.20 CCF48755.1 - 3.8e-13 49.4 0.1 9.4e-13 48.1 0.0 1.6 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 CCF48755.1 - 0.00013 21.6 0.0 0.00023 20.8 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 CCF48755.1 - 0.063 13.4 0.0 0.13 12.3 0.0 1.5 1 0 0 1 1 1 0 Inositol hexakisphosphate DUF4746 PF15928.5 CCF48755.1 - 0.36 10.2 1.7 0.5 9.7 0.7 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) ThiF PF00899.21 CCF48756.1 - 3.8e-102 340.8 0.0 1.8e-67 227.3 0.0 2.1 2 0 0 2 2 2 2 ThiF family UBA_e1_thiolCys PF10585.9 CCF48756.1 - 1.8e-89 300.0 0.5 2.9e-89 299.3 0.5 1.3 1 0 0 1 1 1 1 Ubiquitin-activating enzyme active site E1_FCCH PF16190.5 CCF48756.1 - 4.3e-32 110.1 0.2 1e-31 108.9 0.2 1.7 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 FCCH domain E1_UFD PF09358.10 CCF48756.1 - 9e-32 109.6 0.4 2e-31 108.5 0.4 1.7 1 0 0 1 1 1 1 Ubiquitin fold domain E1_4HB PF16191.5 CCF48756.1 - 8.5e-27 93.2 0.8 2.1e-26 91.9 0.8 1.7 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 four-helix bundle Shikimate_DH PF01488.20 CCF48756.1 - 0.0093 16.0 0.0 0.053 13.6 0.0 2.1 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase FeoB_Cyto PF17910.1 CCF48756.1 - 0.05 14.2 0.0 0.21 12.1 0.0 2.1 2 0 0 2 2 2 0 FeoB cytosolic helical domain 2-Hacid_dh_C PF02826.19 CCF48756.1 - 0.12 11.8 0.1 0.96 8.8 0.0 2.2 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain SnoaL_2 PF12680.7 CCF48757.1 - 0.14 12.8 0.0 2.8 8.6 0.0 2.5 2 0 0 2 2 2 0 SnoaL-like domain Glyco_hydro_18 PF00704.28 CCF48758.1 - 4.5e-59 200.7 0.8 5.4e-59 200.5 0.8 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 UPF0561 PF10573.9 CCF48758.1 - 0.63 10.2 4.0 0.76 9.9 1.5 2.1 2 0 0 2 2 2 0 Uncharacterised protein family UPF0561 Pap_E4 PF02711.14 CCF48758.1 - 1.4 10.0 4.6 12 6.9 5.8 1.9 2 0 0 2 2 2 0 E4 protein SR-25 PF10500.9 CCF48758.1 - 4.3 6.9 15.7 1.5 8.4 11.2 2.0 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein 2-Hacid_dh_C PF02826.19 CCF48759.1 - 6.8e-31 107.0 1.1 7.4e-31 106.9 0.3 1.5 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_7 PF13241.6 CCF48759.1 - 0.0063 16.9 0.1 0.018 15.5 0.1 1.8 1 1 0 1 1 1 1 Putative NAD(P)-binding AdoHcyase_NAD PF00670.21 CCF48759.1 - 0.012 15.7 0.9 0.055 13.5 0.9 2.0 1 1 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain DUF2325 PF10087.9 CCF48759.1 - 0.023 14.8 0.1 0.33 11.1 0.0 2.2 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2325) Shikimate_DH PF01488.20 CCF48759.1 - 0.046 13.8 0.1 0.084 12.9 0.1 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase PPR_2 PF13041.6 CCF48760.1 - 0.037 14.2 0.0 0.14 12.4 0.0 1.9 2 0 0 2 2 2 0 PPR repeat family V-SNARE PF05008.15 CCF48760.1 - 0.058 13.8 1.1 0.32 11.4 1.1 2.3 2 0 0 2 2 2 0 Vesicle transport v-SNARE protein N-terminus PPR_3 PF13812.6 CCF48760.1 - 0.085 13.0 0.0 0.95 9.6 0.0 2.4 2 0 0 2 2 2 0 Pentatricopeptide repeat domain ribosomal_L24 PF17136.4 CCF48761.1 - 0.00036 20.9 0.1 0.0013 19.1 0.0 2.0 2 0 0 2 2 2 1 Ribosomal proteins 50S L24/mitochondrial 39S L24 Planc_extracel PF07595.12 CCF48761.1 - 0.019 14.8 1.0 0.019 14.8 1.0 2.4 3 0 0 3 3 3 0 Planctomycete extracellular DUF2502 PF10697.9 CCF48761.1 - 0.046 14.1 2.4 0.19 12.1 2.4 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2502) ALG3 PF05208.13 CCF48763.1 - 8.4e-128 426.8 12.3 1.4e-127 426.0 12.3 1.4 1 0 0 1 1 1 1 ALG3 protein Gaa1 PF04114.14 CCF48763.1 - 2.6e-78 264.3 1.5 2.6e-78 264.3 1.5 2.9 2 1 0 2 2 2 1 Gaa1-like, GPI transamidase component TAF4 PF05236.14 CCF48764.1 - 1.4e-39 136.6 2.1 2.7e-39 135.6 2.1 1.5 1 1 0 1 1 1 1 Transcription initiation factor TFIID component TAF4 family DUF3886 PF13025.6 CCF48764.1 - 9.9 6.4 10.1 17 5.7 0.1 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF3886) Got1 PF04178.12 CCF48765.1 - 1.6e-18 67.2 13.6 1.6e-18 67.2 13.6 1.5 1 1 1 2 2 2 1 Got1/Sft2-like family LIM_bind PF01803.16 CCF48766.1 - 5.6e-45 153.8 0.0 5.6e-45 153.8 0.0 4.8 3 2 1 4 4 4 1 LIM-domain binding protein RVT_2 PF07727.14 CCF48767.1 - 5.5e-45 153.9 0.2 8.9e-45 153.2 0.2 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 CCF48767.1 - 5.3e-09 36.3 0.0 1.1e-08 35.3 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain DUF3546 PF12066.8 CCF48768.1 - 1.7e-14 53.9 5.4 3.8e-14 52.8 2.5 2.6 2 0 0 2 2 2 1 Domain of unknown function (DUF3546) ARS2 PF04959.13 CCF48768.1 - 1.2e-10 42.1 0.0 3e-10 40.8 0.0 1.7 1 0 0 1 1 1 1 Arsenite-resistance protein 2 NusG PF02357.19 CCF48768.1 - 0.039 14.5 0.0 0.16 12.5 0.0 1.9 2 0 0 2 2 2 0 Transcription termination factor nusG RRM_1 PF00076.22 CCF48768.1 - 0.053 13.4 0.0 0.22 11.4 0.0 2.1 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF1543 PF07566.12 CCF48768.1 - 0.055 13.2 0.2 0.26 11.1 0.2 2.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1543) MIF4G_like PF09088.11 CCF48769.1 - 3.4e-76 255.3 0.0 6.2e-76 254.4 0.0 1.4 1 0 0 1 1 1 1 MIF4G like MIF4G_like_2 PF09090.11 CCF48769.1 - 4e-66 223.2 0.5 8.1e-66 222.2 0.5 1.5 1 0 0 1 1 1 1 MIF4G like DUF5398 PF17376.2 CCF48769.1 - 0.45 11.2 3.7 9.7 6.9 0.2 3.3 3 0 0 3 3 3 0 Family of unknown function (DUF5398) Spt4 PF06093.13 CCF48770.1 - 1.4e-32 111.6 0.1 1.6e-32 111.5 0.1 1.0 1 0 0 1 1 1 1 Spt4/RpoE2 zinc finger Cyclin_N PF00134.23 CCF48771.1 - 2.3e-12 46.8 0.3 2.9e-11 43.2 0.1 2.2 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C_2 PF16899.5 CCF48771.1 - 0.11 12.9 0.0 0.25 11.7 0.0 1.6 1 0 0 1 1 1 0 Cyclin C-terminal domain CPBP PF02517.16 CCF48772.1 - 4.1e-14 52.7 8.2 4.1e-14 52.7 8.2 2.3 2 1 0 2 2 2 1 CPBP intramembrane metalloprotease AAA PF00004.29 CCF48773.1 - 0.077 13.4 0.1 0.23 11.9 0.1 1.9 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) NTPase_1 PF03266.15 CCF48773.1 - 0.12 12.3 0.3 15 5.4 0.1 2.4 2 0 0 2 2 2 0 NTPase GAGA_bind PF06217.12 CCF48773.1 - 4.5 7.5 8.9 0.46 10.7 1.4 2.6 3 0 0 3 3 3 0 GAGA binding protein-like family RICTOR_N PF14664.6 CCF48775.1 - 7.7e-103 344.3 0.6 1.2e-102 343.7 0.6 1.3 1 0 0 1 1 1 1 Rapamycin-insensitive companion of mTOR, N-term RICTOR_M PF14666.6 CCF48775.1 - 3.2e-40 136.1 1.5 4.9e-36 122.6 0.0 5.0 5 0 0 5 5 5 2 Rapamycin-insensitive companion of mTOR, middle domain RasGEF_N_2 PF14663.6 CCF48775.1 - 1.4e-33 115.5 2.0 1.7e-32 112.0 0.2 3.2 3 0 0 3 3 3 1 Rapamycin-insensitive companion of mTOR RasGEF_N domain RICTOR_V PF14668.6 CCF48775.1 - 6.5e-32 109.6 1.4 6.1e-29 100.1 0.1 4.6 5 0 0 5 5 5 1 Rapamycin-insensitive companion of mTOR, domain 5 HR1 PF02185.16 CCF48775.1 - 1.9e-14 53.5 3.9 6.1e-14 51.9 3.9 2.0 1 0 0 1 1 1 1 Hr1 repeat BUD22 PF09073.10 CCF48775.1 - 0.092 12.1 13.8 0.0081 15.6 7.6 2.2 2 0 0 2 2 2 0 BUD22 HEAT PF02985.22 CCF48775.1 - 3.9 8.0 7.8 29 5.3 0.0 4.8 5 0 0 5 5 5 0 HEAT repeat Thioredoxin PF00085.20 CCF48776.1 - 9.5e-39 131.5 0.1 5.8e-21 74.4 0.0 3.7 4 0 0 4 4 4 2 Thioredoxin Thioredoxin_6 PF13848.6 CCF48776.1 - 2.5e-11 43.8 0.0 1.1e-07 31.9 0.0 4.2 3 2 1 4 4 4 1 Thioredoxin-like domain Thioredoxin_2 PF13098.6 CCF48776.1 - 1.5e-08 35.1 0.0 0.0083 16.6 0.0 3.0 3 0 0 3 3 3 2 Thioredoxin-like domain Thioredoxin_8 PF13905.6 CCF48776.1 - 0.00013 22.2 0.1 0.037 14.4 0.0 4.0 4 0 0 4 4 4 1 Thioredoxin-like Thioredoxin_3 PF13192.6 CCF48776.1 - 0.002 18.1 0.0 0.7 10.0 0.0 2.7 2 0 0 2 2 2 1 Thioredoxin domain Thioredoxin_7 PF13899.6 CCF48776.1 - 0.003 17.7 0.0 0.12 12.6 0.0 2.8 3 0 0 3 3 3 1 Thioredoxin-like AhpC-TSA PF00578.21 CCF48776.1 - 0.014 15.3 0.4 0.11 12.4 0.0 2.5 3 0 0 3 3 3 0 AhpC/TSA family SSP160 PF06933.11 CCF48776.1 - 0.023 12.9 11.3 0.041 12.1 11.3 1.3 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Glutaredoxin PF00462.24 CCF48776.1 - 0.21 11.9 1.0 0.54 10.5 0.1 2.2 2 0 0 2 2 2 0 Glutaredoxin Thioredoxin_4 PF13462.6 CCF48776.1 - 0.21 11.7 6.8 1.7 8.8 0.1 3.1 3 1 0 3 3 3 0 Thioredoxin Dicty_REP PF05086.12 CCF48776.1 - 0.84 7.5 1.6 1.2 7.0 1.6 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DUF3439 PF11921.8 CCF48776.1 - 1 9.4 9.8 2.3 8.2 9.8 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) TipE PF16972.5 CCF48776.1 - 1.1 8.4 5.3 1.6 7.8 5.3 1.2 1 0 0 1 1 1 0 Na+ channel auxiliary subunit TipE FSA_C PF10479.9 CCF48776.1 - 2.8 6.0 7.9 5.4 5.0 7.9 1.4 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus His_biosynth PF00977.21 CCF48777.1 - 4.5e-35 121.2 0.1 3.2e-34 118.4 0.0 1.9 2 0 0 2 2 2 1 Histidine biosynthesis protein GST_N PF02798.20 CCF48777.1 - 5.9e-10 39.3 0.0 1.7e-09 37.9 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 CCF48777.1 - 2.2e-05 24.8 0.1 4.2e-05 23.9 0.1 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 CCF48777.1 - 0.00046 20.4 0.1 0.00094 19.4 0.1 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 CCF48777.1 - 0.0018 18.4 0.0 0.0049 17.1 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 CCF48777.1 - 0.19 11.9 0.0 1.2 9.3 0.0 2.1 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain Actin PF00022.19 CCF48778.1 - 1e-149 498.6 0.0 3.8e-149 496.7 0.0 1.7 1 1 0 1 1 1 1 Actin Vps8 PF12816.7 CCF48778.1 - 0.15 11.5 0.0 0.26 10.8 0.0 1.3 1 0 0 1 1 1 0 Golgi CORVET complex core vacuolar protein 8 Methyltransf_29 PF03141.16 CCF48778.1 - 0.18 10.3 0.0 0.27 9.8 0.0 1.2 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase SLT PF01464.20 CCF48779.1 - 7.5e-16 57.8 0.6 1.6e-15 56.8 0.0 1.9 2 0 0 2 2 2 1 Transglycosylase SLT domain DMA PF03474.14 CCF48779.1 - 0.034 13.7 0.0 0.07 12.7 0.0 1.4 1 0 0 1 1 1 0 DMRTA motif Rad10 PF03834.14 CCF48780.1 - 3.3e-47 159.2 0.0 5.5e-47 158.5 0.0 1.4 1 0 0 1 1 1 1 Binding domain of DNA repair protein Ercc1 (rad10/Swi10) HHH_5 PF14520.6 CCF48780.1 - 0.0011 19.6 0.0 0.0021 18.6 0.0 1.4 1 0 0 1 1 1 1 Helix-hairpin-helix domain UIM PF02809.20 CCF48780.1 - 0.02 14.8 0.5 0.039 13.9 0.5 1.5 1 0 0 1 1 1 0 Ubiquitin interaction motif Ribosomal_L2_C PF03947.18 CCF48781.1 - 7e-46 155.5 2.9 1.2e-45 154.8 2.9 1.3 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 CCF48781.1 - 4.3e-13 49.0 0.2 1.1e-12 47.7 0.2 1.7 1 0 0 1 1 1 1 Ribosomal Proteins L2, RNA binding domain GTP_EFTU PF00009.27 CCF48786.1 - 1.4e-34 119.3 1.4 2.8e-34 118.4 0.0 2.3 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain IF-2 PF11987.8 CCF48786.1 - 2.3e-17 63.0 0.2 9.9e-17 61.0 0.0 2.2 2 0 0 2 2 2 1 Translation-initiation factor 2 GTP_EFTU_D2 PF03144.25 CCF48786.1 - 9.2e-14 51.6 7.0 1.1e-09 38.5 0.2 3.3 3 0 0 3 3 3 2 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 CCF48786.1 - 2.3e-06 27.7 0.0 1.1e-05 25.4 0.0 2.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Roc PF08477.13 CCF48786.1 - 0.0003 21.0 0.0 0.0012 19.0 0.0 2.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU_D4 PF14578.6 CCF48786.1 - 0.0014 18.5 0.1 0.0048 16.8 0.1 2.0 1 0 0 1 1 1 1 Elongation factor Tu domain 4 ATP_bind_1 PF03029.17 CCF48786.1 - 0.027 14.2 0.0 0.065 13.0 0.0 1.7 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein AAA_22 PF13401.6 CCF48786.1 - 0.087 13.1 0.7 0.65 10.3 0.1 2.7 2 1 0 2 2 2 0 AAA domain Cgr1 PF03879.14 CCF48787.1 - 4.9e-18 65.5 26.7 5.7e-18 65.3 26.7 1.0 1 0 0 1 1 1 1 Cgr1 family DUF737 PF05300.11 CCF48787.1 - 0.39 11.0 16.2 0.43 10.9 16.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF737) DUF4637 PF15470.6 CCF48787.1 - 0.4 10.4 7.6 0.47 10.2 7.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) Phlebovirus_NSM PF07246.11 CCF48787.1 - 0.7 9.2 10.2 0.33 10.3 8.3 1.3 1 1 0 1 1 1 0 Phlebovirus nonstructural protein NS-M Borrelia_P83 PF05262.11 CCF48787.1 - 2.5 6.5 15.1 2.7 6.4 15.1 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein RR_TM4-6 PF06459.12 CCF48787.1 - 3.5 7.4 11.1 3.8 7.3 11.1 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Presenilin PF01080.17 CCF48787.1 - 9.4 4.9 6.4 9.8 4.8 6.4 1.0 1 0 0 1 1 1 0 Presenilin DUF2433 PF10360.9 CCF48788.1 - 6.3e-45 152.3 0.9 1.1e-44 151.5 0.9 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2433) RRM_1 PF00076.22 CCF48788.1 - 0.011 15.5 0.0 0.44 10.4 0.0 2.6 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Metallophos_2 PF12850.7 CCF48788.1 - 0.027 14.7 0.0 0.088 13.0 0.0 1.8 2 0 0 2 2 2 0 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.28 CCF48788.1 - 0.13 12.7 0.0 0.41 11.1 0.0 1.7 1 1 0 1 1 1 0 Calcineurin-like phosphoesterase HLH PF00010.26 CCF48789.1 - 6.6e-16 58.0 0.3 1.3e-15 57.1 0.3 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Glyoxalase PF00903.25 CCF48789.1 - 0.023 14.9 0.2 0.041 14.1 0.2 1.5 1 1 0 1 1 1 0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily HALZ PF02183.18 CCF48789.1 - 0.069 13.4 0.2 0.14 12.4 0.2 1.5 1 0 0 1 1 1 0 Homeobox associated leucine zipper DUF2312 PF10073.9 CCF48789.1 - 0.13 11.9 0.1 0.31 10.7 0.1 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2312) DUF4776 PF16003.5 CCF48789.1 - 0.14 11.2 0.1 0.18 10.8 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4776) CPSase_L_D2 PF02786.17 CCF48790.1 - 1.7e-106 354.5 0.0 6.6e-82 274.1 0.0 2.5 3 0 0 3 3 3 2 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_L_D3 PF02787.19 CCF48790.1 - 3.3e-39 134.0 0.9 9e-39 132.6 0.5 2.0 2 0 0 2 2 2 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain ATP-grasp PF02222.22 CCF48790.1 - 9.8e-17 61.0 0.0 2.1e-07 30.7 0.0 2.3 2 0 0 2 2 2 2 ATP-grasp domain Dala_Dala_lig_C PF07478.13 CCF48790.1 - 7e-15 55.1 0.1 2.4e-06 27.2 0.1 2.6 2 0 0 2 2 2 2 D-ala D-ala ligase C-terminus ATPgrasp_Ter PF15632.6 CCF48790.1 - 5.1e-12 45.7 0.0 0.00017 21.4 0.0 2.8 2 1 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon RimK PF08443.11 CCF48790.1 - 1.7e-06 27.8 0.0 0.0048 16.5 0.0 2.9 3 0 0 3 3 3 2 RimK-like ATP-grasp domain ATP-grasp_3 PF02655.14 CCF48790.1 - 5.4e-06 26.6 0.0 0.00042 20.4 0.0 2.6 2 0 0 2 2 2 1 ATP-grasp domain ATP-grasp_5 PF13549.6 CCF48790.1 - 1.4e-05 24.7 0.6 0.028 13.9 0.1 2.5 2 0 0 2 2 2 2 ATP-grasp domain MGS PF02142.22 CCF48790.1 - 0.0071 16.5 0.0 0.034 14.3 0.0 2.2 2 0 0 2 2 2 1 MGS-like domain Peptidase_M17_N PF02789.17 CCF48790.1 - 0.025 14.4 0.1 0.094 12.6 0.0 2.0 2 0 0 2 2 2 0 Cytosol aminopeptidase family, N-terminal domain GARS_A PF01071.19 CCF48790.1 - 0.042 13.6 0.1 6.3 6.5 0.1 2.7 3 0 0 3 3 3 0 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain Epimerase PF01370.21 CCF48790.1 - 0.043 13.3 0.0 0.34 10.3 0.0 2.4 3 0 0 3 3 3 0 NAD dependent epimerase/dehydratase family ATP-grasp_2 PF08442.10 CCF48790.1 - 0.083 12.4 0.0 9.5 5.7 0.0 2.6 2 0 0 2 2 2 0 ATP-grasp domain zf-C2H2_assoc3 PF16637.5 CCF48791.1 - 0.016 15.3 2.5 0.024 14.8 2.5 1.4 1 0 0 1 1 1 0 Putative zinc-finger between two C2H2 zinc-fingers on Patz Peptidase_S8_N PF16361.5 CCF48791.1 - 0.023 15.2 0.1 0.035 14.6 0.0 1.4 1 1 0 1 1 1 0 N-terminal of Subtilase family DUF459 PF04311.13 CCF48791.1 - 0.032 13.2 0.1 0.038 13.0 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF459) AlphaC_N PF08829.10 CCF48791.1 - 0.1 12.6 0.2 0.3 11.1 0.0 1.9 2 1 0 2 2 2 0 Alpha C protein N terminal Myb_DNA-binding PF00249.31 CCF48791.1 - 0.49 10.6 3.0 2.2 8.6 3.0 2.0 1 1 0 1 1 1 0 Myb-like DNA-binding domain DEAD PF00270.29 CCF48792.1 - 4.8e-40 137.2 0.0 1e-39 136.1 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CCF48792.1 - 7.5e-18 64.9 0.0 2.4e-17 63.3 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 CCF48792.1 - 1.1e-16 60.8 0.5 2.7e-16 59.5 0.5 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 CCF48792.1 - 1.1e-06 28.8 0.0 2.8e-06 27.4 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Flavi_DEAD PF07652.14 CCF48792.1 - 0.4 10.6 1.7 12 5.8 0.0 2.5 2 0 0 2 2 2 0 Flavivirus DEAD domain SDA1 PF05285.12 CCF48793.1 - 9.2e-89 298.3 67.6 3.4e-88 296.4 60.7 3.0 2 1 0 2 2 2 2 SDA1 NUC130_3NT PF08158.12 CCF48793.1 - 6.2e-18 64.9 0.0 1.6e-17 63.6 0.0 1.8 1 0 0 1 1 1 1 NUC130/3NT domain VTC PF09359.10 CCF48794.1 - 2e-100 335.7 0.1 2e-100 335.7 0.1 1.7 2 0 0 2 2 2 1 VTC domain SPX PF03105.19 CCF48794.1 - 2.2e-17 64.1 31.6 2.8e-06 27.5 1.0 4.5 3 2 1 4 4 4 3 SPX domain DUF202 PF02656.15 CCF48794.1 - 2.2e-11 44.0 0.9 8.1e-11 42.2 0.7 2.1 3 0 0 3 3 3 1 Domain of unknown function (DUF202) DUF1319 PF07028.11 CCF48794.1 - 0.19 11.9 1.2 0.64 10.3 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1319) GAGBD PF16828.5 CCF48794.1 - 0.55 10.3 4.8 0.37 10.9 1.1 2.2 2 0 0 2 2 2 0 GAG-binding domain on surface antigen Forkhead PF00250.18 CCF48795.1 - 2.3e-26 91.9 0.1 4.5e-26 90.9 0.1 1.5 1 0 0 1 1 1 1 Forkhead domain SelP_N PF04592.14 CCF48795.1 - 0.15 11.4 14.4 0.36 10.2 14.4 1.6 1 0 0 1 1 1 0 Selenoprotein P, N terminal region SH3_1 PF00018.28 CCF48797.1 - 4.2e-10 39.1 0.1 6.1e-10 38.6 0.1 1.2 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 CCF48797.1 - 1.1e-07 31.6 0.1 1.7e-07 31.0 0.1 1.3 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 CCF48797.1 - 9.3e-07 28.4 0.0 1.5e-06 27.8 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain Nop PF01798.18 CCF48798.1 - 1.9e-85 286.0 0.1 1.9e-85 286.0 0.1 2.1 2 0 0 2 2 2 1 snoRNA binding domain, fibrillarin NOP5NT PF08156.13 CCF48798.1 - 3.6e-15 56.1 0.2 3.6e-15 56.1 0.2 2.7 2 0 0 2 2 2 1 NOP5NT (NUC127) domain RP-C_C PF11800.8 CCF48798.1 - 6.2 6.9 9.3 43 4.1 0.0 2.3 2 0 0 2 2 2 0 Replication protein C C-terminal region Proteasome PF00227.26 CCF48799.1 - 2.5e-49 167.4 2.0 8.1e-46 155.9 0.3 2.2 1 1 1 2 2 2 2 Proteasome subunit Proteasome_A_N PF10584.9 CCF48799.1 - 6.6e-15 54.5 0.4 1.2e-14 53.6 0.4 1.5 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Cpn60_TCP1 PF00118.24 CCF48800.1 - 1.4e-148 495.6 13.9 1.6e-148 495.4 13.9 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family CRM1_repeat PF18777.1 CCF48800.1 - 0.073 12.6 0.0 0.15 11.6 0.0 1.5 1 0 0 1 1 1 0 Chromosome region maintenance or exportin repeat ABC_membrane PF00664.23 CCF48802.1 - 1e-56 192.6 13.5 2.7e-34 119.1 4.1 3.5 3 0 0 3 3 3 2 ABC transporter transmembrane region ABC_tran PF00005.27 CCF48802.1 - 4.8e-50 169.6 0.0 2.8e-30 105.6 0.0 2.5 2 0 0 2 2 2 2 ABC transporter AAA_16 PF13191.6 CCF48802.1 - 3.6e-10 40.5 0.1 2.3e-05 24.9 0.0 3.1 2 1 0 2 2 2 2 AAA ATPase domain SMC_N PF02463.19 CCF48802.1 - 7e-10 38.7 4.9 0.00033 20.2 0.1 4.2 2 2 1 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CCF48802.1 - 2.2e-08 33.7 1.0 0.00013 21.7 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_23 PF13476.6 CCF48802.1 - 4.3e-08 33.9 0.1 2e-05 25.2 0.0 2.6 2 0 0 2 2 2 1 AAA domain DUF87 PF01935.17 CCF48802.1 - 8.4e-07 29.3 0.4 0.016 15.4 0.2 2.6 2 0 0 2 2 2 2 Helicase HerA, central domain AAA_21 PF13304.6 CCF48802.1 - 1.9e-05 24.6 8.2 0.027 14.3 0.3 3.7 3 1 1 4 4 3 2 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 CCF48802.1 - 0.00011 22.2 0.2 0.047 13.6 0.0 2.5 2 0 0 2 2 2 1 RsgA GTPase MMR_HSR1 PF01926.23 CCF48802.1 - 0.00011 22.2 2.1 0.074 13.1 0.0 2.9 3 0 0 3 3 2 2 50S ribosome-binding GTPase T2SSE PF00437.20 CCF48802.1 - 0.00011 21.3 0.1 0.0028 16.8 0.0 2.3 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_22 PF13401.6 CCF48802.1 - 0.00013 22.3 0.7 0.33 11.2 0.0 3.8 4 0 0 4 4 3 1 AAA domain TrwB_AAD_bind PF10412.9 CCF48802.1 - 0.00014 20.9 0.0 0.3 10.0 0.0 2.3 2 0 0 2 2 2 2 Type IV secretion-system coupling protein DNA-binding domain cobW PF02492.19 CCF48802.1 - 0.0035 17.0 0.3 0.023 14.3 0.0 2.3 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_18 PF13238.6 CCF48802.1 - 0.0042 17.6 0.0 1.9 9.0 0.0 3.1 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.6 CCF48802.1 - 0.0047 16.5 0.0 1.3 8.6 0.0 2.5 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.12 CCF48802.1 - 0.0056 16.0 0.1 0.46 9.7 0.0 2.4 2 0 0 2 2 2 1 Zeta toxin IstB_IS21 PF01695.17 CCF48802.1 - 0.0061 16.3 0.4 9.6 5.9 0.0 3.2 3 0 0 3 3 3 0 IstB-like ATP binding protein AAA_30 PF13604.6 CCF48802.1 - 0.0064 16.2 1.5 0.36 10.5 0.0 3.2 3 0 0 3 3 3 1 AAA domain AAA_7 PF12775.7 CCF48802.1 - 0.0071 15.9 0.1 1.1 8.7 0.0 2.3 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_10 PF12846.7 CCF48802.1 - 0.013 14.4 0.1 0.44 9.4 0.1 2.4 2 0 0 2 2 2 0 AAA-like domain Sigma54_activat PF00158.26 CCF48802.1 - 0.014 15.1 0.0 4.9 6.8 0.0 2.4 2 0 0 2 2 2 0 Sigma-54 interaction domain DUF815 PF05673.13 CCF48802.1 - 0.018 14.2 0.0 5 6.2 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF815) RNA_helicase PF00910.22 CCF48802.1 - 0.019 15.4 0.2 12 6.4 0.0 2.7 2 0 0 2 2 2 0 RNA helicase NACHT PF05729.12 CCF48802.1 - 0.019 14.9 1.8 2.5 8.0 0.1 2.9 2 0 0 2 2 2 0 NACHT domain Adeno_IVa2 PF02456.15 CCF48802.1 - 0.026 13.3 0.1 0.14 10.9 0.0 2.1 2 0 0 2 2 2 0 Adenovirus IVa2 protein FtsK_SpoIIIE PF01580.18 CCF48802.1 - 0.026 13.9 0.2 5.7 6.2 0.0 2.6 3 0 0 3 3 2 0 FtsK/SpoIIIE family KAP_NTPase PF07693.14 CCF48802.1 - 0.029 13.6 0.0 2.1 7.5 0.0 2.3 2 0 0 2 2 2 0 KAP family P-loop domain DEAD PF00270.29 CCF48802.1 - 0.034 13.9 0.0 13 5.5 0.0 3.2 3 0 0 3 3 3 0 DEAD/DEAH box helicase ATPase_2 PF01637.18 CCF48802.1 - 0.043 13.7 0.0 0.26 11.1 0.0 2.1 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea AAA_24 PF13479.6 CCF48802.1 - 0.044 13.5 0.0 2.6 7.7 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA PF00004.29 CCF48802.1 - 0.06 13.8 0.1 11 6.4 0.0 3.3 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) CbiA PF01656.23 CCF48802.1 - 0.077 13.0 0.0 15 5.7 0.0 2.7 2 1 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain DUF2075 PF09848.9 CCF48802.1 - 0.087 12.0 0.2 1.9 7.6 0.0 2.2 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) CLP1_P PF16575.5 CCF48802.1 - 0.09 12.6 0.1 6.1 6.6 0.0 2.9 2 0 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_5 PF07728.14 CCF48802.1 - 0.11 12.5 0.1 31 4.5 0.0 3.1 3 0 0 3 3 2 0 AAA domain (dynein-related subfamily) Dynamin_N PF00350.23 CCF48802.1 - 0.13 12.4 5.7 0.8 9.7 0.1 2.9 3 0 0 3 3 3 0 Dynamin family AAA_15 PF13175.6 CCF48802.1 - 0.13 12.0 0.1 2.9 7.5 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain AAA_27 PF13514.6 CCF48802.1 - 0.13 11.8 0.0 0.28 10.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain SbcCD_C PF13558.6 CCF48802.1 - 0.2 11.9 0.5 5 7.4 0.1 2.9 2 0 0 2 2 2 0 Putative exonuclease SbcCD, C subunit AAA_33 PF13671.6 CCF48802.1 - 0.22 11.7 1.8 41 4.3 0.1 3.7 4 0 0 4 4 3 0 AAA domain Roc PF08477.13 CCF48802.1 - 0.23 11.7 0.3 27 5.0 0.1 3.0 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase PhoH PF02562.16 CCF48802.1 - 0.24 10.8 0.7 8.5 5.8 0.0 2.7 3 0 0 3 3 3 0 PhoH-like protein NB-ARC PF00931.22 CCF48802.1 - 0.25 10.5 1.6 4.3 6.5 0.1 2.7 3 0 0 3 3 3 0 NB-ARC domain ABC_ATPase PF09818.9 CCF48802.1 - 0.83 8.4 3.1 8 5.1 0.0 2.8 3 0 0 3 3 3 0 Predicted ATPase of the ABC class KH_6 PF15985.5 CCF48803.1 - 1.2e-12 47.9 0.0 3.2e-12 46.6 0.0 1.8 1 0 0 1 1 1 1 KH domain ECR1_N PF14382.6 CCF48803.1 - 1.2e-05 25.1 0.0 2e-05 24.3 0.0 1.4 1 0 0 1 1 1 1 Exosome complex exonuclease RRP4 N-terminal region DUF5586 PF17824.1 CCF48803.1 - 0.0092 15.1 0.1 0.015 14.5 0.1 1.4 1 0 0 1 1 1 1 Family of unknown function (DUF5586) BRCT_2 PF16589.5 CCF48804.1 - 0.00012 22.4 0.0 0.00034 21.0 0.0 1.7 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain Myb_DNA-bind_2 PF08914.11 CCF48804.1 - 0.0013 18.9 3.0 0.5 10.6 0.0 3.2 2 1 0 2 2 2 2 Rap1 Myb domain BRCT_3 PF18428.1 CCF48804.1 - 0.0022 18.1 0.0 0.0054 16.8 0.0 1.7 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain Rap1-DNA-bind PF09197.10 CCF48804.1 - 0.016 15.8 0.4 0.016 15.8 0.4 3.2 2 0 0 2 2 2 0 Rap1, DNA-binding HSP70 PF00012.20 CCF48804.1 - 9.1 4.3 14.9 16 3.5 14.9 1.3 1 0 0 1 1 1 0 Hsp70 protein DHBP_synthase PF00926.19 CCF48805.1 - 5.6e-83 277.2 0.0 6.5e-83 277.0 0.0 1.0 1 0 0 1 1 1 1 3,4-dihydroxy-2-butanone 4-phosphate synthase TPR_1 PF00515.28 CCF48806.1 - 1.2e-07 31.2 6.9 0.017 15.0 0.9 6.1 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_2 PF07719.17 CCF48806.1 - 4e-07 29.6 29.4 0.078 13.1 0.9 9.6 10 0 0 10 10 10 4 Tetratricopeptide repeat TPR_19 PF14559.6 CCF48806.1 - 0.00078 19.9 42.6 0.2 12.2 0.5 11.1 10 1 1 11 11 11 4 Tetratricopeptide repeat TPR_11 PF13414.6 CCF48806.1 - 0.00081 19.0 11.5 0.0086 15.7 0.1 6.2 6 0 0 6 6 6 1 TPR repeat TPR_16 PF13432.6 CCF48806.1 - 0.011 16.4 0.1 0.011 16.4 0.1 9.3 9 2 0 10 10 10 0 Tetratricopeptide repeat TPR_8 PF13181.6 CCF48806.1 - 0.031 14.5 12.8 8 7.0 0.3 7.0 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_6 PF13174.6 CCF48806.1 - 0.073 13.7 23.9 0.19 12.5 0.1 9.7 10 0 0 10 10 10 0 Tetratricopeptide repeat TPR_14 PF13428.6 CCF48806.1 - 0.12 13.3 50.4 0.38 11.7 0.1 11.6 12 1 1 13 13 13 0 Tetratricopeptide repeat MCU PF04678.13 CCF48806.1 - 0.99 9.5 5.5 2 8.5 3.7 2.5 2 0 0 2 2 2 0 Mitochondrial calcium uniporter SNO PF01174.19 CCF48807.1 - 1.7e-54 184.5 0.0 3e-43 147.9 0.0 2.1 2 0 0 2 2 2 2 SNO glutamine amidotransferase family GATase_3 PF07685.14 CCF48807.1 - 6.9e-11 42.1 0.0 1.1e-10 41.5 0.0 1.2 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain Peptidase_S51 PF03575.17 CCF48807.1 - 2.2e-05 24.2 0.0 3.7e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 Peptidase family S51 GATase PF00117.28 CCF48807.1 - 5e-05 23.2 0.1 0.013 15.3 0.0 2.2 2 0 0 2 2 2 2 Glutamine amidotransferase class-I DJ-1_PfpI PF01965.24 CCF48807.1 - 0.00055 19.8 0.0 0.001 18.9 0.0 1.3 1 0 0 1 1 1 1 DJ-1/PfpI family BPL_N PF09825.9 CCF48807.1 - 0.09 11.8 0.0 5.4 6.0 0.0 2.1 2 0 0 2 2 2 0 Biotin-protein ligase, N terminal CBFD_NFYB_HMF PF00808.23 CCF48808.1 - 2.7e-25 88.4 0.4 3.6e-25 88.0 0.4 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 CCF48808.1 - 0.00026 21.3 0.8 0.0004 20.7 0.0 1.7 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 CCF48808.1 - 0.022 14.9 0.0 0.035 14.2 0.0 1.3 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T histone fold TFIID-18kDa PF02269.16 CCF48808.1 - 0.082 12.9 0.0 0.11 12.5 0.0 1.2 1 0 0 1 1 1 0 Transcription initiation factor IID, 18kD subunit PIP5K PF01504.18 CCF48809.1 - 1.1e-36 126.5 0.0 4.2e-36 124.6 0.0 2.0 1 1 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase Ric8 PF10165.9 CCF48810.1 - 8.3e-133 443.8 0.1 1.1e-132 443.4 0.1 1.1 1 0 0 1 1 1 1 Guanine nucleotide exchange factor synembryn PIG-X PF08320.12 CCF48811.1 - 1.3e-18 67.7 0.0 8.4e-06 25.8 0.0 3.2 3 0 0 3 3 3 3 PIG-X / PBN1 SNF2_N PF00176.23 CCF48813.1 - 1.5e-62 211.4 4.0 6.6e-62 209.3 0.5 2.5 1 1 1 2 2 2 2 SNF2 family N-terminal domain Helicase_C PF00271.31 CCF48813.1 - 1.2e-18 67.4 0.1 1.1e-17 64.3 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ERCC3_RAD25_C PF16203.5 CCF48813.1 - 0.12 11.6 1.1 0.16 11.1 0.1 1.7 2 0 0 2 2 2 0 ERCC3/RAD25/XPB C-terminal helicase ADH_N PF08240.12 CCF48814.1 - 2.7e-25 88.3 2.4 7.2e-25 87.0 2.4 1.8 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CCF48814.1 - 1.7e-21 76.6 0.5 3.1e-21 75.7 0.5 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 CCF48814.1 - 0.0004 19.8 0.1 0.00078 18.9 0.1 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.21 CCF48814.1 - 0.032 13.5 0.4 0.055 12.8 0.4 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain DUF1304 PF06993.12 CCF48814.1 - 0.19 11.8 1.0 0.37 10.8 1.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1304) Asp PF00026.23 CCF48815.1 - 5.3e-07 29.4 0.8 0.0081 15.6 0.3 3.1 3 0 0 3 3 3 2 Eukaryotic aspartyl protease TAXi_N PF14543.6 CCF48815.1 - 0.00018 21.8 1.1 0.0018 18.5 1.1 2.2 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 CCF48815.1 - 0.025 15.2 0.1 24 5.7 0.1 3.7 3 0 0 3 3 3 0 Aspartyl protease gag-asp_proteas PF13975.6 CCF48815.1 - 0.2 12.2 0.0 18 6.0 0.0 3.6 4 0 0 4 4 4 0 gag-polyprotein putative aspartyl protease Mur_ligase_M PF08245.12 CCF48816.1 - 0.0046 17.0 0.0 0.0092 16.0 0.0 1.5 1 0 0 1 1 1 1 Mur ligase middle domain He_PIG_assoc PF10632.9 CCF48816.1 - 0.069 12.8 0.1 0.17 11.5 0.1 1.7 1 0 0 1 1 1 0 He_PIG associated, NEW1 domain of bacterial glycohydrolase HEPN_Toprim_N PF18871.1 CCF48816.1 - 0.94 9.4 4.7 12 5.7 0.0 2.3 2 0 0 2 2 2 0 HEPN/Toprim N-terminal domain 1 Glyco_hydro_cc PF11790.8 CCF48817.1 - 1.8e-60 204.5 8.6 2.2e-60 204.2 8.6 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase catalytic core Glyco_hydro_53 PF07745.13 CCF48817.1 - 0.0014 17.7 1.3 0.0029 16.6 0.2 1.9 2 0 0 2 2 2 1 Glycosyl hydrolase family 53 Glyco_hydro_2_C PF02836.17 CCF48817.1 - 0.0056 15.8 0.1 0.0088 15.2 0.1 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Med13_C PF06333.12 CCF48818.1 - 1.8e-06 27.5 1.5 1.8e-06 27.5 1.5 6.1 7 0 0 7 7 7 2 Mediator complex subunit 13 C-terminal domain PPR_2 PF13041.6 CCF48819.1 - 2.8e-46 155.5 2.7 1.5e-10 41.1 0.0 11.5 10 2 4 14 14 14 7 PPR repeat family PPR PF01535.20 CCF48819.1 - 8.7e-30 100.9 11.7 0.00014 21.8 0.0 13.1 16 0 0 16 16 15 6 PPR repeat PPR_1 PF12854.7 CCF48819.1 - 4.5e-26 90.3 2.8 9.9e-07 28.4 0.0 9.7 10 0 0 10 10 10 4 PPR repeat PPR_3 PF13812.6 CCF48819.1 - 2.7e-24 85.0 0.0 7.2e-09 35.6 0.0 7.4 6 1 2 8 8 8 6 Pentatricopeptide repeat domain PPR_long PF17177.4 CCF48819.1 - 5.4e-18 65.1 7.9 8e-12 45.0 0.0 5.7 6 0 0 6 6 6 3 Pentacotripeptide-repeat region of PRORP Methyltransf_11 PF08241.12 CCF48819.1 - 6.9e-15 55.5 0.0 1.4e-13 51.3 0.0 3.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF48819.1 - 2.5e-13 50.5 0.0 4.3e-12 46.6 0.0 3.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF48819.1 - 1.8e-09 38.2 0.0 8.9e-09 36.0 0.0 2.4 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCF48819.1 - 3.9e-09 36.6 0.0 1.3e-08 34.9 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF48819.1 - 3.6e-08 33.4 0.0 8.7e-08 32.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CCF48819.1 - 5.4e-07 29.2 0.0 1.3e-06 27.9 0.0 1.6 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family TPR_14 PF13428.6 CCF48819.1 - 0.0006 20.4 8.6 0.24 12.3 0.0 7.4 8 0 0 8 8 7 1 Tetratricopeptide repeat RPM2 PF08579.11 CCF48819.1 - 0.021 15.2 0.0 1.4 9.4 0.0 3.5 4 0 0 4 4 4 0 Mitochondrial ribonuclease P subunit (RPM2) DJ-1_PfpI PF01965.24 CCF48819.1 - 0.022 14.6 0.0 0.059 13.2 0.0 1.7 1 0 0 1 1 1 0 DJ-1/PfpI family Methyltransf_32 PF13679.6 CCF48819.1 - 0.098 12.6 0.0 0.6 10.1 0.0 2.3 2 0 0 2 2 2 0 Methyltransferase domain Kinesin PF00225.23 CCF48820.1 - 4e-110 367.9 0.0 6.1e-110 367.3 0.0 1.3 1 0 0 1 1 1 1 Kinesin motor domain Kinesin_assoc PF16183.5 CCF48820.1 - 3.8e-40 137.9 11.1 8.5e-34 117.3 1.3 3.3 2 1 1 3 3 3 2 Kinesin-associated DUF3694 PF12473.8 CCF48820.1 - 1.2e-37 129.9 0.1 3.2e-36 125.3 0.0 2.9 3 0 0 3 3 3 1 Kinesin protein Microtub_bd PF16796.5 CCF48820.1 - 2.6e-26 92.3 0.0 6.8e-26 91.0 0.0 1.7 1 0 0 1 1 1 1 Microtubule binding PH PF00169.29 CCF48820.1 - 5.3e-12 46.2 0.0 1.4e-11 44.8 0.0 1.7 1 0 0 1 1 1 1 PH domain KIF1B PF12423.8 CCF48820.1 - 7.4e-06 26.3 0.2 2.1e-05 24.8 0.2 1.9 1 0 0 1 1 1 1 Kinesin protein 1B FHA PF00498.26 CCF48820.1 - 4.5e-05 23.7 0.0 0.00018 21.8 0.0 2.0 2 0 0 2 2 2 1 FHA domain EAP30 PF04157.16 CCF48820.1 - 0.029 13.7 0.4 0.14 11.4 0.2 2.3 2 0 0 2 2 2 0 EAP30/Vps36 family Fungal_trans PF04082.18 CCF48823.1 - 5.7e-17 61.6 0.0 2e-16 59.9 0.0 1.9 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF48823.1 - 6.2e-08 32.6 10.1 1.2e-07 31.7 10.1 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 CCF48824.1 - 5.9e-15 55.0 0.0 1.1e-14 54.2 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF48824.1 - 9.8e-09 35.2 9.8 1.7e-08 34.4 9.8 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain zf-CCHC PF00098.23 CCF48825.1 - 0.0037 17.3 1.5 0.0077 16.3 1.5 1.6 1 0 0 1 1 1 1 Zinc knuckle MINDY_DUB PF04424.13 CCF48826.1 - 3.6e-27 94.7 0.0 7e-27 93.8 0.0 1.5 1 0 0 1 1 1 1 MINDY deubiquitinase Aminotran_4 PF01063.19 CCF48826.1 - 1.3e-10 41.6 0.1 3.5e-09 36.9 0.1 2.7 1 1 0 1 1 1 1 Amino-transferase class IV RdRP PF05183.12 CCF48827.1 - 7.2e-167 556.6 0.0 9.2e-167 556.2 0.0 1.1 1 0 0 1 1 1 1 RNA dependent RNA polymerase RVT_2 PF07727.14 CCF48829.1 - 3.6e-31 108.7 0.1 6.3e-31 107.9 0.1 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) MLTD_N PF06474.12 CCF48829.1 - 0.11 12.7 0.0 0.2 11.9 0.0 1.4 1 0 0 1 1 1 0 MltD lipid attachment motif Pro_isomerase PF00160.21 CCF48830.1 - 4e-46 157.2 0.0 6.9e-46 156.4 0.0 1.3 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TPR_1 PF00515.28 CCF48830.1 - 0.18 11.7 4.5 1.6 8.7 0.8 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.17 CCF48830.1 - 0.53 10.5 5.2 4.6 7.6 1.2 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat Tcf25 PF04910.14 CCF48831.1 - 6.8e-111 370.7 0.0 9.3e-111 370.3 0.0 1.2 1 0 0 1 1 1 1 Transcriptional repressor TCF25 YL1 PF05764.13 CCF48831.1 - 0.044 13.9 18.4 0.094 12.8 18.4 1.5 1 0 0 1 1 1 0 YL1 nuclear protein DUF4484 PF14831.6 CCF48831.1 - 1.3 9.0 12.2 3 7.9 12.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4484) TFIIF_alpha PF05793.12 CCF48831.1 - 4.5 5.7 25.1 8.9 4.8 25.1 1.4 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) CDC45 PF02724.14 CCF48831.1 - 6 5.0 14.1 9.6 4.4 14.1 1.3 1 0 0 1 1 1 0 CDC45-like protein DUF4776 PF16003.5 CCF48831.1 - 9.6 5.1 15.2 14 4.5 15.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4776) SCO1-SenC PF02630.14 CCF48832.1 - 2.2e-44 150.6 0.0 3.2e-44 150.1 0.0 1.3 1 0 0 1 1 1 1 SCO1/SenC Thioredoxin_8 PF13905.6 CCF48832.1 - 0.0041 17.4 0.0 0.0074 16.6 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin-like Eaf7 PF07904.13 CCF48833.1 - 5.6e-10 39.5 3.0 5.6e-10 39.5 3.0 4.4 4 2 0 4 4 4 1 Chromatin modification-related protein EAF7 ACOX PF01756.19 CCF48834.1 - 3.5e-27 95.1 0.0 8.4e-25 87.4 0.0 2.3 2 0 0 2 2 2 2 Acyl-CoA oxidase Acyl-CoA_ox_N PF14749.6 CCF48834.1 - 1.5e-13 51.4 0.2 2.7e-13 50.6 0.2 1.4 1 0 0 1 1 1 1 Acyl-coenzyme A oxidase N-terminal Acyl-CoA_dh_M PF02770.19 CCF48834.1 - 3.8e-10 39.8 0.0 7.3e-10 38.9 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Methyltransf_25 PF13649.6 CCF48835.1 - 0.00075 20.2 0.0 0.0022 18.6 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF48835.1 - 0.0014 19.3 0.0 0.0044 17.6 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF48835.1 - 0.0065 16.3 0.0 0.013 15.3 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF48835.1 - 0.041 14.6 0.0 0.21 12.4 0.0 2.1 2 0 0 2 2 2 0 Methyltransferase domain Fumble PF03630.14 CCF48836.1 - 3.4e-125 417.6 0.0 6e-125 416.8 0.0 1.4 1 0 0 1 1 1 1 Fumble V-SNARE PF05008.15 CCF48837.1 - 8.9e-22 77.3 11.9 1.2e-21 76.9 3.6 2.4 2 0 0 2 2 2 1 Vesicle transport v-SNARE protein N-terminus V-SNARE_C PF12352.8 CCF48837.1 - 1.3e-16 60.7 6.9 1.3e-16 60.7 6.9 2.0 2 0 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus DUF883 PF05957.13 CCF48837.1 - 0.00074 20.1 10.1 0.092 13.4 0.3 3.2 1 1 1 3 3 3 2 Bacterial protein of unknown function (DUF883) Sec20 PF03908.13 CCF48837.1 - 0.0017 18.3 0.4 0.0017 18.3 0.4 1.9 2 0 0 2 2 2 1 Sec20 Fusion_gly PF00523.18 CCF48837.1 - 0.02 13.1 0.1 0.034 12.4 0.1 1.5 1 0 0 1 1 1 0 Fusion glycoprotein F0 PTS_IIA PF02255.16 CCF48837.1 - 0.026 14.5 1.7 6 7.0 0.0 2.4 2 0 0 2 2 2 0 PTS system, Lactose/Cellobiose specific IIA subunit DUF4362 PF14275.6 CCF48837.1 - 0.027 14.7 2.0 2 8.8 0.3 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4362) Prominin PF05478.11 CCF48837.1 - 0.042 11.8 7.3 0.23 9.4 7.3 1.9 1 1 0 1 1 1 0 Prominin YqjK PF13997.6 CCF48837.1 - 0.062 13.6 1.1 0.062 13.6 1.1 2.2 2 0 0 2 2 2 0 YqjK-like protein T2SSF PF00482.23 CCF48837.1 - 0.12 12.3 3.1 0.64 10.0 1.2 2.3 1 1 1 2 2 2 0 Type II secretion system (T2SS), protein F OppC_N PF12911.7 CCF48837.1 - 0.13 12.2 1.0 0.23 11.5 1.0 1.4 1 0 0 1 1 1 0 N-terminal TM domain of oligopeptide transport permease C Orf78 PF06024.12 CCF48837.1 - 0.17 12.2 1.9 0.28 11.5 0.1 2.1 2 0 0 2 2 2 0 Orf78 (ac78) TBCA PF02970.16 CCF48837.1 - 0.17 12.2 7.3 0.9 9.9 1.1 2.5 2 0 0 2 2 2 0 Tubulin binding cofactor A Synaptobrevin PF00957.21 CCF48837.1 - 0.31 10.8 2.9 0.21 11.4 0.3 2.1 2 0 0 2 2 2 0 Synaptobrevin FAM184 PF15665.5 CCF48837.1 - 1.7 8.4 11.4 0.22 11.3 1.7 2.1 2 0 0 2 2 2 0 Family with sequence similarity 184, A and B zf-CpG_bind_C PF12269.8 CCF48837.1 - 2 8.1 7.1 0.72 9.6 0.5 2.1 2 0 0 2 2 2 0 CpG binding protein zinc finger C terminal domain DUF3391 PF11871.8 CCF48837.1 - 2.2 8.8 14.9 13 6.3 2.7 2.7 1 1 1 2 2 2 0 Domain of unknown function (DUF3391) Sec8_exocyst PF04048.14 CCF48837.1 - 4.6 7.1 7.3 1.5 8.7 0.6 2.5 2 1 1 3 3 3 0 Sec8 exocyst complex component specific domain DUF2203 PF09969.9 CCF48837.1 - 7 7.4 12.0 1.8 9.3 1.1 2.8 1 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) Myotub-related PF06602.14 CCF48838.1 - 4.9e-141 469.7 0.0 6.3e-141 469.4 0.0 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain Vps36_ESCRT-II PF11605.8 CCF48838.1 - 0.073 13.3 0.1 0.22 11.7 0.0 1.8 2 0 0 2 2 2 0 Vacuolar protein sorting protein 36 Vps36 Y_phosphatase PF00102.27 CCF48838.1 - 0.079 12.5 0.0 0.16 11.5 0.0 1.4 1 0 0 1 1 1 0 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 CCF48838.1 - 0.12 12.3 0.0 0.22 11.4 0.0 1.4 1 0 0 1 1 1 0 Tyrosine phosphatase family DSPc PF00782.20 CCF48838.1 - 0.19 11.5 0.0 0.39 10.5 0.0 1.4 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain Cation_efflux PF01545.21 CCF48839.1 - 2.5e-26 92.6 9.7 3.8e-26 92.1 9.7 1.3 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 CCF48839.1 - 9.3e-05 22.5 0.0 0.00019 21.5 0.0 1.5 1 0 0 1 1 1 1 Dimerisation domain of Zinc Transporter Myb_DNA-bind_6 PF13921.6 CCF48839.1 - 0.15 12.4 0.1 0.47 10.7 0.1 1.8 1 0 0 1 1 1 0 Myb-like DNA-binding domain WD40 PF00400.32 CCF48840.1 - 0.00012 22.8 14.8 1.1 10.2 0.3 5.8 5 2 0 5 5 5 2 WD domain, G-beta repeat RF-1 PF00472.20 CCF48841.1 - 1e-24 86.7 1.9 1.3e-24 86.4 1.9 1.1 1 0 0 1 1 1 1 RF-1 domain BLACT_WH PF17778.1 CCF48841.1 - 0.097 12.7 1.0 0.32 11.0 1.0 1.9 1 0 0 1 1 1 0 Beta-lactamase associated winged helix domain GCS PF03074.16 CCF48842.1 - 2.9e-172 573.1 0.0 3.6e-172 572.8 0.0 1.1 1 0 0 1 1 1 1 Glutamate-cysteine ligase DUF1769 PF08588.10 CCF48843.1 - 1.8e-26 92.1 0.2 3.2e-26 91.3 0.2 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1769) KH_1 PF00013.29 CCF48844.1 - 2.1e-07 30.7 0.3 1.5e-05 24.8 0.2 2.5 2 0 0 2 2 2 2 KH domain Trp_repressor PF01371.19 CCF48844.1 - 0.018 15.2 0.1 0.041 14.0 0.1 1.5 1 0 0 1 1 1 0 Trp repressor protein PGI PF00342.19 CCF48845.1 - 2.9e-227 755.0 0.5 3.3e-227 754.8 0.5 1.0 1 0 0 1 1 1 1 Phosphoglucose isomerase HMG_box_2 PF09011.10 CCF48846.1 - 2.5e-15 56.8 11.9 7.4e-10 39.3 0.5 2.9 3 0 0 3 3 3 2 HMG-box domain HMG_box PF00505.19 CCF48846.1 - 1.1e-14 54.5 21.2 7.2e-10 39.1 1.7 3.9 3 2 0 3 3 3 2 HMG (high mobility group) box Death PF00531.22 CCF48846.1 - 0.0019 18.3 1.1 0.036 14.2 0.1 2.8 3 0 0 3 3 3 1 Death domain GCV_T PF01571.21 CCF48848.1 - 0.00036 20.0 0.0 0.00071 19.0 0.0 1.4 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain TrmO_C PF18389.1 CCF48848.1 - 0.17 12.0 0.0 0.48 10.6 0.0 1.7 2 0 0 2 2 2 0 TrmO C-terminal domain AhpC-TSA_2 PF13911.6 CCF48849.1 - 8e-13 48.5 0.0 1.7e-12 47.5 0.0 1.5 1 0 0 1 1 1 1 AhpC/TSA antioxidant enzyme AhpC-TSA PF00578.21 CCF48849.1 - 4.4e-08 33.1 0.0 1e-07 31.9 0.0 1.5 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 CCF48849.1 - 1.8e-07 31.0 0.0 3.8e-07 29.9 0.0 1.5 1 0 0 1 1 1 1 Redoxin LtrA PF06772.11 CCF48850.1 - 8.9e-32 110.7 20.1 3.4e-18 66.0 13.3 2.1 2 0 0 2 2 2 2 Bacterial low temperature requirement A protein (LtrA) RNB PF00773.19 CCF48851.1 - 7.6e-47 160.2 0.0 4.6e-46 157.6 0.0 2.1 1 1 0 1 1 1 1 RNB domain Ras PF00071.22 CCF48852.1 - 3.6e-35 121.0 0.1 4.2e-35 120.7 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CCF48852.1 - 2.8e-26 92.1 0.1 3.9e-26 91.6 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CCF48852.1 - 5.2e-08 32.5 0.0 6.3e-08 32.3 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 CCF48852.1 - 1.2e-06 28.1 0.1 1.5e-06 27.8 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region DLIC PF05783.11 CCF48852.1 - 0.0094 14.8 0.2 0.83 8.4 0.0 2.1 1 1 1 2 2 2 2 Dynein light intermediate chain (DLIC) SRPRB PF09439.10 CCF48852.1 - 0.056 12.9 0.0 0.081 12.4 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 CCF48852.1 - 0.063 13.4 0.0 0.09 12.9 0.0 1.4 1 1 0 1 1 1 0 50S ribosome-binding GTPase PBP5_C PF07943.13 CCF48852.1 - 0.081 13.2 0.0 0.24 11.7 0.0 1.8 2 0 0 2 2 2 0 Penicillin-binding protein 5, C-terminal domain TniB PF05621.11 CCF48852.1 - 0.11 11.9 0.0 1.9 7.9 0.0 2.3 2 1 0 2 2 2 0 Bacterial TniB protein G-alpha PF00503.20 CCF48852.1 - 0.13 11.4 0.4 0.26 10.4 0.1 1.6 1 1 1 2 2 2 0 G-protein alpha subunit NadA PF02445.16 CCF48852.1 - 0.16 11.1 0.1 14 4.7 0.0 2.0 2 0 0 2 2 2 0 Quinolinate synthetase A protein PAPA-1 PF04795.12 CCF48853.1 - 3.8e-24 85.3 7.8 3.8e-24 85.3 7.8 5.4 5 1 1 6 6 6 1 PAPA-1-like conserved region MCR_gamma PF02240.16 CCF48854.1 - 0.027 13.7 0.3 0.059 12.6 0.1 1.6 2 0 0 2 2 2 0 Methyl-coenzyme M reductase gamma subunit GAGA_bind PF06217.12 CCF48854.1 - 0.65 10.2 10.3 1.9 8.7 3.1 2.1 2 0 0 2 2 2 0 GAGA binding protein-like family Folate_carrier PF01770.18 CCF48854.1 - 1 8.0 2.0 1.4 7.5 2.0 1.1 1 0 0 1 1 1 0 Reduced folate carrier UBN_AB PF14075.6 CCF48856.1 - 3e-45 154.6 1.0 3e-45 154.6 1.0 2.7 2 1 0 2 2 2 1 Ubinuclein conserved middle domain HUN PF08729.10 CCF48856.1 - 2.9e-12 46.4 1.4 2.9e-12 46.4 1.4 2.6 2 0 0 2 2 2 1 HPC2 and ubinuclein domain CDC45 PF02724.14 CCF48856.1 - 0.0015 16.9 7.5 0.0015 16.9 7.5 2.1 2 0 0 2 2 2 1 CDC45-like protein Endonuc-BglII PF09195.11 CCF48856.1 - 0.12 12.2 0.2 0.22 11.3 0.2 1.3 1 0 0 1 1 1 0 Restriction endonuclease BglII DUF815 PF05673.13 CCF48857.1 - 0.036 13.2 0.0 0.042 13.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF815) NMD3 PF04981.13 CCF48858.1 - 4.3e-85 285.0 2.7 4.3e-85 285.0 2.7 1.6 2 0 0 2 2 2 1 NMD3 family DZR PF12773.7 CCF48858.1 - 0.002 18.1 5.9 0.18 11.9 1.4 2.9 1 1 1 2 2 2 2 Double zinc ribbon Skp1 PF01466.19 CCF48858.1 - 1.2 9.3 5.5 1.3 9.2 4.0 1.8 2 0 0 2 2 2 0 Skp1 family, dimerisation domain DUF2340 PF10209.9 CCF48859.1 - 7.6e-49 165.1 2.5 9.7e-49 164.8 2.5 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2340) DUF4252 PF14060.6 CCF48859.1 - 0.017 15.1 0.2 0.022 14.7 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4252) Blt1 PF12754.7 CCF48859.1 - 0.082 13.2 0.1 0.11 12.8 0.1 1.3 1 0 0 1 1 1 0 Blt1 N-terminal domain GEN1_C PF18380.1 CCF48861.1 - 0.071 14.0 2.1 0.1 13.5 2.1 1.4 1 0 0 1 1 1 0 Holliday junction resolvase Gen1 C-terminal domain NOA36 PF06524.12 CCF48861.1 - 0.093 12.0 16.3 0.12 11.7 16.3 1.2 1 0 0 1 1 1 0 NOA36 protein CNDH2_C PF16858.5 CCF48861.1 - 0.16 11.8 10.7 0.17 11.8 10.7 1.1 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term CPSF100_C PF13299.6 CCF48861.1 - 0.2 11.8 3.8 0.22 11.7 3.8 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Zip PF02535.22 CCF48861.1 - 0.37 10.0 4.0 0.37 10.0 4.0 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter DUF2076 PF09849.9 CCF48861.1 - 0.41 10.6 19.1 0.48 10.4 19.1 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) MAJIN PF15077.6 CCF48861.1 - 0.44 10.3 5.7 0.53 10.0 5.7 1.0 1 0 0 1 1 1 0 Membrane-anchored junction protein Nop14 PF04147.12 CCF48861.1 - 0.59 8.3 13.4 0.62 8.2 13.4 1.0 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.14 CCF48861.1 - 0.73 8.0 8.9 0.76 8.0 8.9 1.1 1 0 0 1 1 1 0 CDC45-like protein DNA_pol_phi PF04931.13 CCF48861.1 - 0.99 7.4 12.9 1.2 7.2 12.9 1.1 1 0 0 1 1 1 0 DNA polymerase phi NPR3 PF03666.13 CCF48861.1 - 1.3 7.7 11.3 1.3 7.7 11.3 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Striatin PF08232.12 CCF48861.1 - 2.5 8.7 8.4 3.4 8.3 8.4 1.3 1 1 0 1 1 1 0 Striatin family TFB6 PF17110.5 CCF48861.1 - 2.8 7.7 5.9 3.4 7.4 5.9 1.3 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH DUF4637 PF15470.6 CCF48861.1 - 4.2 7.1 9.1 6.3 6.5 9.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) V_ATPase_I PF01496.19 CCF48861.1 - 6.6 4.5 6.8 7.1 4.4 6.8 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Presenilin PF01080.17 CCF48861.1 - 7.2 5.3 10.4 8 5.1 10.4 1.1 1 0 0 1 1 1 0 Presenilin Osteopontin PF00865.18 CCF48861.1 - 8.9 5.7 21.5 12 5.3 21.5 1.2 1 0 0 1 1 1 0 Osteopontin Whi5 PF08528.11 CCF48862.1 - 7.7e-06 25.4 0.1 1.5e-05 24.5 0.1 1.5 1 0 0 1 1 1 1 Whi5 like TRAPP PF04051.16 CCF48863.1 - 3.6e-38 130.5 0.0 5.8e-38 129.9 0.0 1.3 1 1 0 1 1 1 1 Transport protein particle (TRAPP) component dsDNA_bind PF01984.20 CCF48864.1 - 6.8e-35 119.7 2.3 1.1e-34 119.0 2.3 1.3 1 1 0 1 1 1 1 Double-stranded DNA-binding domain Steroid_dh PF02544.16 CCF48865.1 - 3.2e-26 92.1 5.7 2.1e-19 70.0 5.4 4.4 2 1 0 2 2 2 2 3-oxo-5-alpha-steroid 4-dehydrogenase DUF1295 PF06966.12 CCF48865.1 - 0.00027 20.5 0.1 0.00042 19.9 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) RVT_2 PF07727.14 CCF48866.1 - 1.5e-09 37.9 0.0 2.2e-09 37.3 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) JmjC PF02373.22 CCF48867.1 - 7.9e-16 58.5 0.0 2.2e-15 57.1 0.0 1.8 1 0 0 1 1 1 1 JmjC domain, hydroxylase Cupin_8 PF13621.6 CCF48867.1 - 2.3e-05 24.2 0.0 0.29 10.8 0.0 3.2 3 2 0 3 3 3 2 Cupin-like domain zf-B_box PF00643.24 CCF48867.1 - 0.17 12.1 4.4 0.43 10.8 4.4 1.6 1 0 0 1 1 1 0 B-box zinc finger FYVE PF01363.21 CCF48867.1 - 2.9 8.1 11.5 0.35 11.0 6.2 2.2 2 0 0 2 2 2 0 FYVE zinc finger RVT_2 PF07727.14 CCF48868.1 - 1.3e-32 113.4 0.7 4.7e-19 69.0 0.1 2.1 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) FKBP_C PF00254.28 CCF48869.1 - 3.8e-33 113.7 0.0 4.4e-33 113.5 0.0 1.0 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase Maf1 PF09174.10 CCF48871.1 - 2.2e-39 135.4 0.0 1.4e-32 113.3 0.0 2.3 2 0 0 2 2 2 2 Maf1 regulator Patatin PF01734.22 CCF48871.1 - 0.99 9.5 7.0 0.28 11.3 3.3 1.8 2 0 0 2 2 2 0 Patatin-like phospholipase TruD PF01142.18 CCF48872.1 - 4.6e-68 229.9 0.0 3e-63 214.1 0.0 4.2 3 1 0 3 3 3 2 tRNA pseudouridine synthase D (TruD) Glyco_hydro_3_C PF01915.22 CCF48873.1 - 1e-45 156.2 0.0 1.5e-45 155.7 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 CCF48873.1 - 1.3e-31 110.2 0.0 1.1e-30 107.1 0.0 2.1 1 1 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 CCF48873.1 - 1.2e-20 73.4 0.1 2.3e-20 72.5 0.1 1.5 1 0 0 1 1 1 1 Fibronectin type III-like domain PGAP1 PF07819.13 CCF48874.1 - 2.7e-59 200.7 0.0 4.2e-59 200.1 0.0 1.3 1 0 0 1 1 1 1 PGAP1-like protein Prot_ATP_OB_N PF17758.1 CCF48876.1 - 0.02 14.5 0.9 5.2 6.8 0.0 3.0 3 0 0 3 3 3 0 Proteasomal ATPase OB N-terminal domain DUF824 PF05688.11 CCF48876.1 - 0.031 14.1 0.0 58 3.6 0.0 3.2 3 0 0 3 3 3 0 Salmonella repeat of unknown function (DUF824) PAC4 PF16093.5 CCF48876.1 - 0.078 13.2 0.0 36 4.6 0.0 3.4 3 1 0 3 3 3 0 Proteasome assembly chaperone 4 Abhydrolase_3 PF07859.13 CCF48880.1 - 7e-16 58.7 0.0 1.2e-15 57.9 0.0 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 CCF48880.1 - 7.2e-11 41.6 0.0 4.7e-08 32.3 0.0 2.1 2 0 0 2 2 2 2 Steryl acetyl hydrolase Peptidase_S9 PF00326.21 CCF48880.1 - 0.059 12.8 0.0 0.11 12.0 0.0 1.4 1 0 0 1 1 1 0 Prolyl oligopeptidase family DUF3605 PF12239.8 CCF48881.1 - 7e-21 75.2 0.0 5e-13 49.7 0.0 2.8 2 1 0 2 2 2 2 Protein of unknown function (DUF3605) DUF4864 PF16156.5 CCF48881.1 - 0.17 12.6 0.0 1.3 9.7 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4864) GMC_oxred_N PF00732.19 CCF48882.1 - 5.1e-58 196.8 0.0 6.7e-58 196.4 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 CCF48882.1 - 6.9e-29 101.2 0.0 1.8e-28 99.9 0.0 1.7 1 0 0 1 1 1 1 GMC oxidoreductase FAD_binding_2 PF00890.24 CCF48882.1 - 9.7e-06 24.9 1.2 0.00027 20.2 1.2 2.2 2 0 0 2 2 2 1 FAD binding domain NAD_binding_8 PF13450.6 CCF48882.1 - 0.00017 21.7 0.9 0.0013 19.0 1.6 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 CCF48882.1 - 0.0014 17.8 0.7 0.0023 17.0 0.7 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein Pyr_redox_2 PF07992.14 CCF48882.1 - 0.0076 15.5 3.7 0.0082 15.4 1.7 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CCF48882.1 - 0.011 15.0 4.1 0.45 9.7 2.5 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 CCF48882.1 - 0.014 14.6 0.3 0.035 13.3 0.3 1.6 1 0 0 1 1 1 0 Thi4 family DAO PF01266.24 CCF48882.1 - 0.017 14.7 2.4 0.036 13.7 2.4 1.6 1 1 0 1 1 1 0 FAD dependent oxidoreductase Solute_trans_a PF03619.16 CCF48884.1 - 2e-81 273.4 30.4 2.6e-81 273.1 30.4 1.1 1 0 0 1 1 1 1 Organic solute transporter Ostalpha DPM3 PF08285.11 CCF48884.1 - 2.4 8.4 9.4 0.068 13.4 1.9 2.2 2 0 0 2 2 2 0 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) WD40 PF00400.32 CCF48885.1 - 6.9e-10 39.4 4.2 0.0027 18.5 0.2 5.1 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF48885.1 - 0.0027 18.0 0.0 13 6.1 0.0 3.9 4 0 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Zn_clus PF00172.18 CCF48886.1 - 2e-06 27.8 7.8 3.8e-06 26.9 7.8 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain RBR PF17208.3 CCF48886.1 - 0.046 14.4 1.4 3.8 8.3 0.0 4.0 3 0 0 3 3 3 0 RNA binding Region Aldedh PF00171.22 CCF48887.1 - 1.1e-124 416.4 0.2 1.3e-124 416.3 0.2 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.11 CCF48887.1 - 0.0022 17.5 0.0 1.8 8.0 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF1487) LuxC PF05893.14 CCF48887.1 - 0.0048 16.0 0.0 0.0079 15.3 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA reductase (LuxC) HORMA PF02301.18 CCF48888.1 - 1.8e-27 96.3 0.0 2.1e-27 96.1 0.0 1.0 1 0 0 1 1 1 1 HORMA domain ATG101 PF07855.12 CCF48888.1 - 0.0053 16.8 0.2 0.014 15.4 0.2 1.6 1 1 0 1 1 1 1 Autophagy-related protein 101 bacHORMA_2 PF18173.1 CCF48888.1 - 0.0079 16.1 0.3 0.031 14.1 0.2 2.0 1 1 1 2 2 2 1 Bacterial HORMA domain 2 Ala_racemase_N PF01168.20 CCF48888.1 - 0.08 12.6 0.0 0.24 11.0 0.0 1.8 2 0 0 2 2 2 0 Alanine racemase, N-terminal domain zf-RING_2 PF13639.6 CCF48889.1 - 7.9e-10 38.9 1.5 7.9e-10 38.9 1.5 3.2 3 0 0 3 3 3 1 Ring finger domain zinc_ribbon_9 PF14369.6 CCF48889.1 - 2.7e-09 37.1 0.7 2.7e-09 37.1 0.7 2.9 3 0 0 3 3 3 1 zinc-ribbon zf-rbx1 PF12678.7 CCF48889.1 - 5.8e-08 32.9 0.3 5.8e-08 32.9 0.3 2.7 3 0 0 3 3 2 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 CCF48889.1 - 1.1e-06 28.4 1.8 1.1e-06 28.4 1.8 3.2 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 CCF48889.1 - 1.1e-06 28.4 10.2 0.00022 21.0 0.5 3.2 3 0 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 CCF48889.1 - 0.00011 21.9 1.0 0.00011 21.9 1.0 3.1 3 0 0 3 3 3 1 Prokaryotic RING finger family 4 zf-RING_11 PF17123.5 CCF48889.1 - 0.00015 21.4 1.3 0.00022 20.9 0.1 1.9 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4 PF00097.25 CCF48889.1 - 0.00038 20.3 0.5 0.00038 20.3 0.5 3.2 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CCF48889.1 - 0.0011 18.9 12.0 0.0028 17.6 0.4 3.3 3 0 0 3 3 3 1 zinc-RING finger domain zf-ANAPC11 PF12861.7 CCF48889.1 - 0.0035 17.4 0.5 0.0035 17.4 0.5 2.3 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.6 CCF48889.1 - 0.0068 16.4 3.4 0.0068 16.4 3.4 2.8 2 1 0 2 2 2 1 RING-type zinc-finger Zn_ribbon_17 PF17120.5 CCF48889.1 - 0.017 14.7 1.0 0.017 14.7 1.0 2.3 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type zf-RING_4 PF14570.6 CCF48889.1 - 0.059 13.2 9.6 0.68 9.8 0.2 3.2 3 0 0 3 3 3 0 RING/Ubox like zinc-binding domain HypA PF01155.19 CCF48889.1 - 0.11 12.6 0.2 0.11 12.6 0.2 2.4 2 1 1 3 3 3 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Zn-ribbon_8 PF09723.10 CCF48889.1 - 0.17 12.1 11.1 0.15 12.2 1.3 3.4 3 0 0 3 3 3 0 Zinc ribbon domain zinc_ribbon_16 PF17034.5 CCF48889.1 - 0.24 11.6 1.9 0.97 9.7 1.9 1.9 1 1 0 1 1 1 0 Zinc-ribbon like family zf-TFIIB PF13453.6 CCF48889.1 - 0.75 9.2 6.6 19 4.7 0.1 3.4 3 0 0 3 3 3 0 Transcription factor zinc-finger DZR PF12773.7 CCF48889.1 - 1.5 8.9 9.4 0.32 11.0 0.3 2.8 2 1 0 2 2 2 0 Double zinc ribbon His_Phos_1 PF00300.22 CCF48890.1 - 2e-14 53.7 1.8 7.3e-09 35.6 0.2 4.1 2 2 0 2 2 2 2 Histidine phosphatase superfamily (branch 1) GMP_synt_C PF00958.22 CCF48891.1 - 2e-43 146.4 0.0 4e-43 145.4 0.0 1.5 1 0 0 1 1 1 1 GMP synthase C terminal domain GATase PF00117.28 CCF48891.1 - 4.6e-37 127.6 0.0 1.2e-36 126.3 0.0 1.6 2 0 0 2 2 2 1 Glutamine amidotransferase class-I NAD_synthase PF02540.17 CCF48891.1 - 1.1e-11 44.3 0.2 2.9e-07 29.9 0.1 2.3 2 0 0 2 2 2 2 NAD synthase Peptidase_C26 PF07722.13 CCF48891.1 - 2.6e-09 37.1 0.0 4.8e-09 36.3 0.0 1.4 1 0 0 1 1 1 1 Peptidase C26 tRNA_Me_trans PF03054.16 CCF48891.1 - 3.9e-05 22.6 0.1 7.3e-05 21.7 0.1 1.4 1 0 0 1 1 1 1 tRNA methyl transferase ThiI PF02568.14 CCF48891.1 - 4.4e-05 23.2 0.0 7.5e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 Thiamine biosynthesis protein (ThiI) Arginosuc_synth PF00764.19 CCF48891.1 - 0.0012 18.2 0.2 0.002 17.5 0.2 1.3 1 0 0 1 1 1 1 Arginosuccinate synthase QueC PF06508.13 CCF48891.1 - 0.0022 17.5 0.0 0.031 13.8 0.1 2.0 2 0 0 2 2 2 1 Queuosine biosynthesis protein QueC PAPS_reduct PF01507.19 CCF48891.1 - 0.014 15.5 0.0 0.022 14.8 0.0 1.3 1 0 0 1 1 1 0 Phosphoadenosine phosphosulfate reductase family sCache_like PF16736.5 CCF48891.1 - 0.095 12.8 0.3 0.17 12.0 0.3 1.3 1 0 0 1 1 1 0 Single Cache-like ATP_bind_3 PF01171.20 CCF48891.1 - 0.16 11.7 0.3 0.38 10.5 0.0 1.7 2 0 0 2 2 2 0 PP-loop family mIF3 PF14877.6 CCF48892.1 - 0.00015 21.5 0.2 0.00015 21.5 0.2 2.1 3 1 0 3 3 3 1 Mitochondrial translation initiation factor SR-25 PF10500.9 CCF48892.1 - 0.0037 16.9 8.6 0.0037 16.9 8.6 2.1 2 0 0 2 2 2 1 Nuclear RNA-splicing-associated protein IF3_N PF05198.16 CCF48892.1 - 0.02 15.2 0.1 0.083 13.2 0.1 2.0 1 1 0 1 1 1 0 Translation initiation factor IF-3, N-terminal domain IF3_C PF00707.22 CCF48892.1 - 0.022 14.7 0.1 0.036 14.0 0.1 1.4 1 0 0 1 1 1 0 Translation initiation factor IF-3, C-terminal domain ATP-synt_E_2 PF08112.11 CCF48892.1 - 0.3 11.4 0.0 0.3 11.4 0.0 2.3 3 0 0 3 3 3 0 ATP synthase epsilon subunit WD40 PF00400.32 CCF48893.1 - 4.2e-09 36.9 5.1 0.025 15.5 0.0 5.7 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF48893.1 - 0.015 15.6 0.0 29 5.1 0.0 3.9 3 2 2 5 5 5 0 Anaphase-promoting complex subunit 4 WD40 domain Cys_Met_Meta_PP PF01053.20 CCF48894.1 - 9.6e-17 60.6 0.0 7.2e-16 57.7 0.0 2.3 2 1 0 2 2 2 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 CCF48894.1 - 0.0061 15.8 0.0 0.01 15.0 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II CTD_bind PF04818.13 CCF48895.1 - 0.0025 18.6 0.0 0.0054 17.5 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase II-binding domain. Zn-C2H2_12 PF18112.1 CCF48895.1 - 0.021 15.3 1.6 0.078 13.5 0.5 2.3 2 1 0 2 2 2 0 Autophagy receptor zinc finger-C2H2 domain FliX PF10768.9 CCF48895.1 - 0.029 14.9 1.5 0.029 14.9 1.5 2.3 2 1 0 2 2 2 0 Class II flagellar assembly regulator ParA PF10609.9 CCF48896.1 - 2.5e-83 279.3 0.0 6.6e-45 153.5 0.0 3.0 3 0 0 3 3 3 3 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 CCF48896.1 - 1.5e-06 28.3 0.1 9.9e-05 22.4 0.2 2.8 2 1 0 2 2 2 1 CobQ/CobB/MinD/ParA nucleotide binding domain ArsA_ATPase PF02374.15 CCF48896.1 - 0.0005 19.3 0.7 0.0026 17.0 0.5 2.1 2 0 0 2 2 2 1 Anion-transporting ATPase RsgA_GTPase PF03193.16 CCF48896.1 - 0.033 14.1 0.0 0.072 13.0 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase AAA_31 PF13614.6 CCF48896.1 - 0.034 14.1 0.2 0.45 10.4 0.1 2.2 2 0 0 2 2 2 0 AAA domain PcrB PF01884.17 CCF48896.1 - 0.042 13.3 0.0 0.065 12.7 0.0 1.2 1 0 0 1 1 1 0 PcrB family NB-ARC PF00931.22 CCF48896.1 - 0.076 12.2 0.0 0.12 11.6 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain AAA_25 PF13481.6 CCF48896.1 - 0.087 12.4 0.0 0.15 11.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_26 PF13500.6 CCF48896.1 - 0.1 12.4 0.0 0.51 10.1 0.0 1.9 2 0 0 2 2 2 0 AAA domain F-box PF00646.33 CCF48898.1 - 0.07 13.0 0.0 0.14 12.1 0.0 1.4 1 0 0 1 1 1 0 F-box domain TOM13 PF08219.11 CCF48899.1 - 2.3e-08 33.9 2.2 3.9e-08 33.1 2.0 1.6 1 1 0 1 1 1 1 Outer membrane protein TOM13 TPR_2 PF07719.17 CCF48900.1 - 5.2e-29 98.0 12.7 7.5e-05 22.5 0.2 9.2 10 0 0 10 10 8 7 Tetratricopeptide repeat TPR_1 PF00515.28 CCF48900.1 - 3.3e-24 83.7 3.9 6.9e-06 25.7 0.1 8.3 8 0 0 8 8 8 4 Tetratricopeptide repeat ANAPC3 PF12895.7 CCF48900.1 - 6.8e-18 64.7 14.1 2.7e-08 33.9 1.3 5.4 4 2 1 5 5 5 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 CCF48900.1 - 3e-15 55.1 1.3 0.13 12.5 0.0 7.7 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_16 PF13432.6 CCF48900.1 - 6e-13 49.2 18.0 6.1e-05 23.6 0.0 6.9 6 1 1 7 7 6 4 Tetratricopeptide repeat TPR_12 PF13424.6 CCF48900.1 - 2.3e-12 47.0 15.6 0.0038 17.5 0.0 7.3 6 1 0 6 6 6 4 Tetratricopeptide repeat TPR_19 PF14559.6 CCF48900.1 - 3.2e-10 40.4 12.6 0.073 13.6 0.4 7.0 5 1 2 7 7 7 4 Tetratricopeptide repeat TPR_14 PF13428.6 CCF48900.1 - 5.8e-10 39.2 23.1 0.014 16.1 0.2 8.6 5 2 3 8 8 8 4 Tetratricopeptide repeat TPR_11 PF13414.6 CCF48900.1 - 3.5e-09 36.2 1.2 0.014 15.1 0.2 6.2 5 1 1 6 6 6 2 TPR repeat TPR_9 PF13371.6 CCF48900.1 - 8.4e-07 29.1 15.9 0.036 14.2 0.0 5.2 4 1 0 5 5 5 3 Tetratricopeptide repeat TPR_17 PF13431.6 CCF48900.1 - 1.8e-06 27.9 2.6 5 7.7 0.0 7.5 9 0 0 9 9 8 1 Tetratricopeptide repeat TPR_6 PF13174.6 CCF48900.1 - 7.1e-05 23.2 14.7 4.9 8.0 0.0 8.4 9 0 0 9 9 9 1 Tetratricopeptide repeat HrpB1_HrpK PF09613.10 CCF48900.1 - 0.0021 17.7 0.4 0.069 12.8 0.1 3.1 3 0 0 3 3 3 1 Bacterial type III secretion protein (HrpB1_HrpK) TPR_MalT PF17874.1 CCF48900.1 - 0.014 14.8 0.1 0.014 14.8 0.1 2.9 5 0 0 5 5 5 0 MalT-like TPR region TPR_10 PF13374.6 CCF48900.1 - 0.014 15.3 5.4 47 4.0 0.0 5.7 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_7 PF13176.6 CCF48900.1 - 2.2 8.5 15.8 1.9e+02 2.4 0.0 7.3 8 0 0 8 8 7 0 Tetratricopeptide repeat Mito_carr PF00153.27 CCF48901.1 - 4.5e-55 183.6 7.8 6.1e-19 67.7 0.3 3.8 4 0 0 4 4 4 3 Mitochondrial carrier protein RVT_2 PF07727.14 CCF48902.1 - 7.8e-15 55.2 0.0 1.1e-14 54.7 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) 2-Hacid_dh_C PF02826.19 CCF48903.1 - 3.3e-41 140.6 0.0 7.1e-40 136.3 0.0 2.1 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 CCF48903.1 - 1.4e-25 89.5 0.0 1.8e-25 89.1 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 CCF48903.1 - 0.00064 19.9 0.0 0.0011 19.2 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 CCF48903.1 - 0.053 14.1 0.0 0.14 12.8 0.0 1.8 1 1 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent NAD_binding_4 PF07993.12 CCF48904.1 - 1.5e-14 53.8 0.3 3.1e-09 36.4 0.0 2.6 2 1 1 3 3 3 2 Male sterility protein 3Beta_HSD PF01073.19 CCF48904.1 - 2.9e-07 29.8 0.0 4.7e-07 29.1 0.0 1.3 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 CCF48904.1 - 7.2e-07 28.9 0.2 2.7e-06 27.0 0.2 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 CCF48904.1 - 0.00019 21.4 0.0 0.00032 20.6 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 CCF48904.1 - 0.00021 20.8 0.4 0.00045 19.7 0.0 1.7 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase NmrA PF05368.13 CCF48904.1 - 0.04 13.5 0.1 0.21 11.1 0.1 2.1 2 1 0 2 2 2 0 NmrA-like family KR PF08659.10 CCF48904.1 - 0.065 13.1 0.3 1.4 8.8 0.2 2.8 2 1 0 2 2 2 0 KR domain E1-E2_ATPase PF00122.20 CCF48905.1 - 9.4e-25 87.2 0.0 9.4e-25 87.2 0.0 3.9 3 2 0 3 3 3 1 E1-E2 ATPase Hydrolase PF00702.26 CCF48905.1 - 6.5e-14 52.7 0.8 3.5e-06 27.5 0.0 3.3 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase P5-ATPase PF12409.8 CCF48905.1 - 1.3e-08 35.0 0.0 4.3e-08 33.3 0.0 2.0 2 0 0 2 2 2 1 P5-type ATPase cation transporter Cation_ATPase PF13246.6 CCF48905.1 - 3.4e-06 27.0 0.0 9.5e-06 25.6 0.0 1.8 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 CCF48905.1 - 8.1e-05 22.2 0.0 0.00018 21.1 0.0 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus DUF3087 PF11286.8 CCF48905.1 - 5 6.6 5.3 3.8 7.0 2.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3087) Sugar_tr PF00083.24 CCF48906.1 - 6.7e-88 295.5 20.1 8.3e-88 295.2 20.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF48906.1 - 1.4e-20 73.5 15.6 1.4e-20 73.5 15.6 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily Malt_amylase_C PF16657.5 CCF48906.1 - 0.016 15.3 0.1 0.036 14.2 0.1 1.5 1 0 0 1 1 1 0 Maltogenic Amylase, C-terminal domain DUF1129 PF06570.11 CCF48906.1 - 0.37 10.3 5.5 0.48 9.9 3.8 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1129) Dynein_AAA_lid PF17852.1 CCF48906.1 - 0.43 10.7 0.0 0.43 10.7 0.0 1.9 2 0 0 2 2 2 0 Dynein heavy chain AAA lid domain Glyco_hydro_15 PF00723.21 CCF48907.1 - 1.4e-78 264.7 0.2 2.1e-78 264.1 0.2 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 15 Abhydrolase_6 PF12697.7 CCF48908.1 - 1.2e-16 62.0 0.2 2.2e-16 61.1 0.2 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 CCF48908.1 - 2.9e-16 59.9 0.1 1e-11 45.0 0.1 2.9 2 1 0 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CCF48908.1 - 1.6e-07 30.9 0.0 6.4e-07 28.9 0.0 1.8 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_4 PF08386.10 CCF48908.1 - 0.0073 16.4 0.0 0.015 15.4 0.0 1.5 1 0 0 1 1 1 1 TAP-like protein QueF PF14489.6 CCF48908.1 - 0.025 14.7 0.0 0.46 10.7 0.0 2.2 2 0 0 2 2 2 0 QueF-like protein Rad60-SLD_2 PF13881.6 CCF48909.1 - 1.9e-13 50.5 3.1 2.9e-13 49.9 0.2 2.5 2 1 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like WD40 PF00400.32 CCF48910.1 - 7.4e-20 70.9 0.2 2.1e-06 28.4 0.1 5.1 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF48910.1 - 0.014 15.7 0.0 10 6.5 0.0 3.1 3 1 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain PH PF00169.29 CCF48911.1 - 4.9e-07 30.2 0.1 1.1e-06 29.1 0.1 1.6 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 CCF48911.1 - 0.00098 19.5 0.1 0.0036 17.7 0.1 2.1 1 0 0 1 1 1 1 Pleckstrin homology domain GATA PF00320.27 CCF48912.1 - 5.7e-12 45.0 4.0 1.1e-11 44.1 4.0 1.5 1 0 0 1 1 1 1 GATA zinc finger WLM PF08325.10 CCF48913.1 - 8.3e-30 104.3 9.3 2.3e-29 102.8 3.5 2.7 2 1 0 2 2 2 1 WLM domain zf-RanBP PF00641.18 CCF48913.1 - 1.2e-05 24.5 3.4 2.4e-05 23.6 3.4 1.5 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others DUF45 PF01863.17 CCF48913.1 - 0.014 15.4 1.6 0.024 14.7 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function DUF45 Vps16_C PF04840.12 CCF48914.1 - 2.4e-71 240.4 3.8 8e-47 159.8 2.8 2.2 2 0 0 2 2 2 2 Vps16, C-terminal region Vps16_N PF04841.13 CCF48914.1 - 3.7e-68 230.2 0.0 1.1e-43 149.5 0.0 3.2 3 0 0 3 3 3 3 Vps16, N-terminal region DUF1168 PF06658.12 CCF48915.1 - 1.9e-42 144.3 18.0 2.7e-42 143.8 18.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1168) CAML PF14963.6 CCF48915.1 - 3.9 7.5 9.5 6.7 6.7 9.5 1.3 1 0 0 1 1 1 0 Calcium signal-modulating cyclophilin ligand Abhydrolase_3 PF07859.13 CCF48916.1 - 1.6e-24 86.9 0.0 2.9e-24 86.1 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 CCF48916.1 - 2.2e-05 23.5 0.0 3.2e-05 23.0 0.0 1.1 1 0 0 1 1 1 1 Steryl acetyl hydrolase UQ_con PF00179.26 CCF48917.1 - 3.7e-18 65.5 0.0 5.3e-18 65.0 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Ras PF00071.22 CCF48918.1 - 5.7e-46 156.1 0.0 7e-46 155.8 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CCF48918.1 - 4.2e-21 75.4 0.0 6.1e-21 74.9 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CCF48918.1 - 2.1e-07 30.5 0.0 2.8e-07 30.2 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family AAA_16 PF13191.6 CCF48918.1 - 0.092 13.1 0.0 0.14 12.5 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain SRPRB PF09439.10 CCF48918.1 - 0.11 11.9 0.0 0.14 11.6 0.0 1.1 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit ERCC3_RAD25_C PF16203.5 CCF48919.1 - 3.3e-124 413.0 0.1 7e-124 411.9 0.1 1.5 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase Helicase_C_3 PF13625.6 CCF48919.1 - 1.1e-37 128.9 0.0 2.5e-37 127.9 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 CCF48919.1 - 2.1e-17 63.7 0.0 3.9e-17 62.8 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 CCF48919.1 - 1.9e-10 41.0 0.1 5.7e-10 39.5 0.1 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SNF2_N PF00176.23 CCF48919.1 - 1e-08 34.3 0.0 1.3e-08 34.0 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain DEAD PF00270.29 CCF48919.1 - 1.7e-05 24.7 0.6 4e-05 23.5 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase DUF3275 PF11679.8 CCF48919.1 - 7.7 6.4 7.9 0.14 12.1 0.3 2.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3275) GST_N PF02798.20 CCF48920.1 - 1.1e-15 57.7 0.1 3.5e-15 56.1 0.0 1.8 2 1 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 CCF48920.1 - 2.7e-12 46.9 0.0 5.1e-12 46.0 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 CCF48920.1 - 1.4e-11 44.5 0.0 2.9e-11 43.5 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Ribosomal_L5_C PF00673.21 CCF48921.1 - 3.8e-22 78.3 0.0 7.1e-22 77.4 0.0 1.4 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.19 CCF48921.1 - 1e-18 67.4 0.0 1.7e-18 66.7 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L5 PDZ_5 PF17817.1 CCF48922.1 - 0.012 15.9 0.5 0.054 13.8 0.1 2.2 2 0 0 2 2 2 0 PDZ domain DEAD PF00270.29 CCF48923.1 - 2.5e-47 160.9 0.0 4.9e-47 160.0 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CCF48923.1 - 2.1e-31 108.5 0.0 4.1e-31 107.6 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain UTP25 PF06862.12 CCF48923.1 - 0.042 12.6 0.0 0.068 11.9 0.0 1.2 1 0 0 1 1 1 0 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 ResIII PF04851.15 CCF48923.1 - 0.051 13.6 0.0 0.11 12.4 0.0 1.6 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 CCF48923.1 - 0.24 10.6 0.0 0.39 9.9 0.0 1.2 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase ABC_membrane_2 PF06472.15 CCF48924.1 - 1.5e-92 309.8 5.6 9e-92 307.3 3.6 2.1 2 0 0 2 2 2 1 ABC transporter transmembrane region 2 ABC_tran PF00005.27 CCF48924.1 - 1.7e-15 57.7 0.0 9.2e-15 55.4 0.0 2.2 2 0 0 2 2 2 1 ABC transporter AAA PF00004.29 CCF48924.1 - 0.011 16.2 0.0 0.023 15.1 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 CCF48924.1 - 0.012 16.0 0.7 0.046 14.1 0.0 2.3 2 1 0 2 2 2 0 AAA ATPase domain Mg_chelatase PF01078.21 CCF48924.1 - 0.015 14.7 0.0 0.025 14.0 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI RuvB_N PF05496.12 CCF48924.1 - 0.018 14.8 0.0 0.04 13.6 0.0 1.5 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain ATPase_2 PF01637.18 CCF48924.1 - 0.055 13.4 0.0 2.7 7.8 0.0 2.3 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea AAA_29 PF13555.6 CCF48924.1 - 0.073 12.8 0.0 0.25 11.1 0.0 1.9 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_7 PF12775.7 CCF48924.1 - 0.1 12.1 0.0 0.2 11.1 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region Sigma54_activat PF00158.26 CCF48924.1 - 0.11 12.2 0.0 0.21 11.3 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain SMC_N PF02463.19 CCF48924.1 - 0.15 11.5 0.0 13 5.1 0.1 2.2 1 1 0 2 2 2 0 RecF/RecN/SMC N terminal domain AAA_18 PF13238.6 CCF48924.1 - 0.16 12.5 0.0 0.4 11.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 CCF48924.1 - 0.17 12.4 0.1 0.17 12.4 0.1 2.0 3 0 0 3 3 2 0 AAA domain Ribosomal_L33 PF00471.20 CCF48927.1 - 4.3e-12 46.3 0.1 4.9e-12 46.1 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L33 Peptidase_S10 PF00450.22 CCF48928.1 - 5.4e-96 322.5 4.1 9.3e-96 321.8 4.1 1.4 1 1 0 1 1 1 1 Serine carboxypeptidase rve PF00665.26 CCF48930.1 - 7.1e-07 29.4 0.0 1.2e-06 28.6 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain FeS PF04060.13 CCF48930.1 - 0.079 12.6 0.0 0.2 11.3 0.0 1.8 1 0 0 1 1 1 0 Putative Fe-S cluster hDGE_amylase PF14701.6 CCF48933.1 - 1.3e-169 565.0 0.0 1.7e-169 564.6 0.0 1.1 1 0 0 1 1 1 1 Glycogen debranching enzyme, glucanotransferase domain GDE_C PF06202.14 CCF48933.1 - 7.3e-117 390.5 0.0 1.3e-116 389.7 0.0 1.4 1 0 0 1 1 1 1 Amylo-alpha-1,6-glucosidase hGDE_central PF14702.6 CCF48933.1 - 2.1e-80 270.0 0.0 3.5e-80 269.3 0.0 1.4 1 0 0 1 1 1 1 Central domain of human glycogen debranching enzyme hGDE_N PF14699.6 CCF48933.1 - 3.8e-22 78.2 0.1 9e-22 77.0 0.1 1.7 1 0 0 1 1 1 1 N-terminal domain from the human glycogen debranching enzyme Ran_BP1 PF00638.18 CCF48934.1 - 2.5e-20 73.0 2.0 3.1e-20 72.6 0.0 2.1 2 0 0 2 2 2 1 RanBP1 domain vATP-synt_E PF01991.18 CCF48935.1 - 5.4e-60 202.2 19.1 6.3e-60 202.0 19.1 1.0 1 0 0 1 1 1 1 ATP synthase (E/31 kDa) subunit Marek_A PF02124.15 CCF48935.1 - 0.15 11.8 0.1 0.26 11.1 0.1 1.3 1 0 0 1 1 1 0 Marek's disease glycoprotein A eIF3g PF12353.8 CCF48936.1 - 2.6e-44 150.6 4.0 4.1e-44 150.0 4.0 1.3 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit G RRM_1 PF00076.22 CCF48936.1 - 4.2e-17 61.7 0.0 8.5e-17 60.7 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 CCF48936.1 - 0.11 12.6 0.0 0.33 11.0 0.0 1.8 1 0 0 1 1 1 0 Limkain b1 Ribonucleas_3_3 PF14622.6 CCF48937.1 - 1.1e-31 109.7 0.0 1.8e-31 108.9 0.0 1.4 1 0 0 1 1 1 1 Ribonuclease-III-like Ribonuclease_3 PF00636.26 CCF48937.1 - 1.3e-05 25.8 0.0 5.2e-05 23.8 0.0 2.1 2 0 0 2 2 2 1 Ribonuclease III domain Herpes_UL32 PF06070.11 CCF48937.1 - 4.5 4.9 13.3 5.7 4.5 13.3 1.1 1 0 0 1 1 1 0 Herpesvirus large structural phosphoprotein UL32 HhH-GPD PF00730.25 CCF48938.1 - 5.2e-19 68.7 0.0 1.8e-18 67.0 0.0 1.9 2 0 0 2 2 2 1 HhH-GPD superfamily base excision DNA repair protein NUDIX_4 PF14815.6 CCF48938.1 - 5e-14 52.2 0.2 7.4e-13 48.4 0.2 2.6 1 1 0 1 1 1 1 NUDIX domain HHH PF00633.23 CCF48938.1 - 6.5e-05 22.6 0.0 0.00014 21.5 0.0 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix motif EndIII_4Fe-2S PF10576.9 CCF48938.1 - 0.011 16.0 9.8 0.052 13.9 9.8 2.3 1 0 0 1 1 1 0 Iron-sulfur binding domain of endonuclease III NDUF_B8 PF05821.11 CCF48940.1 - 7.2e-08 32.5 0.2 1.8e-07 31.2 0.2 1.5 1 1 0 1 1 1 1 NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8) Metallophos PF00149.28 CCF48941.1 - 7e-37 127.9 0.6 9.9e-37 127.4 0.6 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 CCF48941.1 - 0.00064 20.1 0.1 0.0013 19.1 0.1 1.4 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain Glyco_hydro_65N PF03636.15 CCF48941.1 - 0.078 12.6 0.0 0.12 12.0 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 65, N-terminal domain ELO PF01151.18 CCF48942.1 - 1.2e-59 201.9 15.4 1.2e-59 201.9 15.4 1.5 2 0 0 2 2 2 1 GNS1/SUR4 family Cpn60_TCP1 PF00118.24 CCF48943.1 - 1.2e-155 518.9 2.0 1.3e-155 518.8 2.0 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Resolvase PF00239.21 CCF48943.1 - 0.11 12.6 0.5 1.1 9.3 0.2 2.3 2 0 0 2 2 2 0 Resolvase, N terminal domain Collagen PF01391.18 CCF48944.1 - 0.0018 18.0 4.2 0.0047 16.7 4.2 1.6 1 0 0 1 1 1 1 Collagen triple helix repeat (20 copies) Fes1 PF08609.10 CCF48945.1 - 1.7e-21 76.9 0.8 4e-21 75.7 0.1 2.0 3 0 0 3 3 3 1 Nucleotide exchange factor Fes1 Arm PF00514.23 CCF48945.1 - 1.2e-06 28.3 0.1 0.0071 16.4 0.0 3.2 2 0 0 2 2 2 2 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 CCF48945.1 - 0.00037 20.8 0.1 0.00095 19.5 0.1 1.7 1 0 0 1 1 1 1 HEAT repeats HEAT PF02985.22 CCF48945.1 - 0.0018 18.4 0.1 7.1 7.2 0.0 3.7 3 0 0 3 3 3 1 HEAT repeat HEAT_EZ PF13513.6 CCF48945.1 - 0.0023 18.4 0.1 0.015 15.8 0.0 2.5 2 0 0 2 2 2 1 HEAT-like repeat DUF3361 PF11841.8 CCF48945.1 - 0.0044 17.0 0.8 0.045 13.7 0.2 2.4 1 1 1 2 2 2 1 Domain of unknown function (DUF3361) TAN PF11640.8 CCF48945.1 - 0.11 12.7 0.0 0.74 9.9 0.0 2.2 2 0 0 2 2 2 0 Telomere-length maintenance and DNA damage repair DUF5578 PF17741.1 CCF48945.1 - 0.12 11.8 0.2 0.21 11.0 0.2 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5578) V-ATPase_H_C PF11698.8 CCF48945.1 - 0.15 12.2 0.1 0.31 11.2 0.1 1.5 1 0 0 1 1 1 0 V-ATPase subunit H zf-RING_2 PF13639.6 CCF48946.1 - 6.2e-12 45.6 10.5 6.2e-12 45.6 10.5 2.2 3 0 0 3 3 2 1 Ring finger domain zf-rbx1 PF12678.7 CCF48946.1 - 3.8e-10 39.9 8.4 1.3e-09 38.2 8.4 1.9 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 CCF48946.1 - 2.2e-07 30.6 10.5 5.5e-07 29.3 10.5 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CCF48946.1 - 6.5e-06 26.1 5.5 2e-05 24.5 5.5 1.9 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 CCF48946.1 - 7.6e-06 25.7 10.7 1.7e-05 24.6 10.7 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CCF48946.1 - 2.7e-05 24.1 8.5 6.4e-05 22.8 8.5 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-ANAPC11 PF12861.7 CCF48946.1 - 3.9e-05 23.6 4.5 9.3e-05 22.4 4.5 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_3 PF13920.6 CCF48946.1 - 0.0001 22.1 7.2 0.0001 22.1 7.2 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 CCF48946.1 - 0.0022 17.7 7.3 0.0022 17.7 7.3 2.0 2 0 0 2 2 2 1 RING-like zinc finger Zn_ribbon_17 PF17120.5 CCF48946.1 - 0.061 12.9 6.0 0.18 11.4 6.0 1.8 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type PHD PF00628.29 CCF48946.1 - 0.17 11.8 8.3 0.45 10.5 8.3 1.8 1 0 0 1 1 1 0 PHD-finger zf-RING_4 PF14570.6 CCF48946.1 - 0.7 9.7 9.6 1.6 8.6 9.6 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Zn-C2H2_12 PF18112.1 CCF48946.1 - 0.86 10.1 3.5 10 6.7 0.1 2.7 2 0 0 2 2 2 0 Autophagy receptor zinc finger-C2H2 domain FANCL_C PF11793.8 CCF48946.1 - 1.1 9.5 8.9 1.1 9.5 6.7 2.2 2 1 0 2 2 2 0 FANCL C-terminal domain RINGv PF12906.7 CCF48946.1 - 1.6 8.9 11.9 1.2 9.3 9.7 2.0 2 0 0 2 2 2 0 RING-variant domain zf-C3H2C3 PF17122.5 CCF48946.1 - 3.3 7.8 7.4 1.6 8.8 3.0 2.4 2 0 0 2 2 2 0 Zinc-finger zf-C3HC4_5 PF17121.5 CCF48946.1 - 3.6 7.5 11.5 2 8.3 8.1 2.4 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 CCF48946.1 - 7.9 6.7 8.2 22 5.3 8.2 1.9 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING PRP3 PF08572.10 CCF48948.1 - 1.7e-67 227.4 9.7 1.7e-67 227.4 9.7 2.1 2 0 0 2 2 2 1 pre-mRNA processing factor 3 (PRP3) DUF1115 PF06544.12 CCF48948.1 - 4.7e-39 133.8 0.8 1.8e-38 131.9 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF1115) Serglycin PF04360.12 CCF48948.1 - 0.34 10.8 3.8 1.1 9.2 3.7 1.9 1 1 0 1 1 1 0 Serglycin PAPS_reduct PF01507.19 CCF48949.1 - 1.3e-21 77.4 0.0 8.7e-17 61.7 0.0 2.2 2 0 0 2 2 2 2 Phosphoadenosine phosphosulfate reductase family BUD22 PF09073.10 CCF48950.1 - 0.084 12.2 18.8 0.0084 15.5 13.7 1.9 2 0 0 2 2 2 0 BUD22 DUF1682 PF07946.14 CCF48950.1 - 0.31 10.2 7.6 0.67 9.1 7.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) FAM199X PF15814.5 CCF48950.1 - 0.53 9.3 25.2 1.2 8.2 15.1 2.4 2 0 0 2 2 2 0 Protein family FAM199X SDA1 PF05285.12 CCF48950.1 - 0.61 9.5 18.1 0.069 12.6 8.2 2.4 2 0 0 2 2 2 0 SDA1 RPN2_C PF18004.1 CCF48950.1 - 1.2 9.1 5.3 3.8 7.4 5.3 1.8 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Sigma70_ner PF04546.13 CCF48950.1 - 1.7 8.5 12.0 4.3 7.2 12.0 1.6 1 0 0 1 1 1 0 Sigma-70, non-essential region Ribosomal_60s PF00428.19 CCF48950.1 - 3.6 8.2 21.2 0.24 12.0 15.3 2.1 2 0 0 2 2 2 0 60s Acidic ribosomal protein Radial_spoke PF04712.12 CCF48950.1 - 9 5.1 16.3 17 4.2 16.3 1.4 1 0 0 1 1 1 0 Radial spokehead-like protein PAT1 PF09770.9 CCF48951.1 - 7.8e-106 355.3 33.1 7.8e-103 345.4 33.1 4.4 1 1 0 1 1 1 1 Topoisomerase II-associated protein PAT1 PDE4_UCR PF18100.1 CCF48951.1 - 0.044 14.4 0.2 0.3 11.7 0.0 2.6 2 0 0 2 2 2 0 Phosphodiesterase 4 upstream conserved regions (UCR) Sec1 PF00995.23 CCF48952.1 - 5.1e-126 422.2 0.0 6.5e-126 421.9 0.0 1.1 1 0 0 1 1 1 1 Sec1 family PMEI PF04043.15 CCF48952.1 - 0.085 13.2 0.4 0.18 12.1 0.4 1.5 1 0 0 1 1 1 0 Plant invertase/pectin methylesterase inhibitor NIF PF03031.18 CCF48953.1 - 5.9e-52 175.6 0.0 1e-51 174.8 0.0 1.4 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase SKI PF01202.22 CCF48955.1 - 2.3e-10 40.8 0.1 5.5e-07 29.8 0.0 2.5 2 1 0 2 2 2 2 Shikimate kinase AAA_33 PF13671.6 CCF48955.1 - 2.4e-06 27.8 0.1 0.0001 22.5 0.1 2.4 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 CCF48955.1 - 7.2e-06 26.6 0.5 0.0032 18.0 0.0 2.5 2 1 0 2 2 2 1 AAA domain AAA_22 PF13401.6 CCF48955.1 - 0.00052 20.3 0.6 0.24 11.7 0.1 2.8 2 1 1 3 3 3 1 AAA domain Cytidylate_kin2 PF13189.6 CCF48955.1 - 0.0062 16.7 0.0 0.062 13.4 0.0 2.2 1 1 1 2 2 2 1 Cytidylate kinase-like family APS_kinase PF01583.20 CCF48955.1 - 0.0068 16.3 0.0 0.024 14.5 0.0 1.9 2 0 0 2 2 2 1 Adenylylsulphate kinase ETF_alpha PF00766.19 CCF48955.1 - 0.008 16.2 1.7 1.3 9.1 0.1 2.4 2 0 0 2 2 2 1 Electron transfer flavoprotein FAD-binding domain Zeta_toxin PF06414.12 CCF48955.1 - 0.014 14.7 0.1 0.046 13.0 0.0 1.9 2 0 0 2 2 2 0 Zeta toxin AAA_16 PF13191.6 CCF48955.1 - 0.018 15.4 2.5 0.057 13.8 2.5 2.1 1 1 0 1 1 1 0 AAA ATPase domain AAA_29 PF13555.6 CCF48955.1 - 0.03 14.1 0.8 0.056 13.2 0.8 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain dNK PF01712.19 CCF48955.1 - 0.031 14.1 0.2 7.1 6.4 0.1 2.3 2 0 0 2 2 2 0 Deoxynucleoside kinase Cytidylate_kin PF02224.18 CCF48955.1 - 0.033 13.9 0.1 0.07 12.9 0.0 1.6 2 0 0 2 2 2 0 Cytidylate kinase KTI12 PF08433.10 CCF48955.1 - 0.036 13.5 0.1 5 6.5 0.0 2.3 2 0 0 2 2 2 0 Chromatin associated protein KTI12 CoaE PF01121.20 CCF48955.1 - 0.094 12.4 0.4 0.24 11.0 0.0 1.8 2 0 0 2 2 2 0 Dephospho-CoA kinase DUF2075 PF09848.9 CCF48955.1 - 0.11 11.7 0.0 0.23 10.7 0.0 1.5 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) AAA_17 PF13207.6 CCF48955.1 - 0.13 12.7 0.3 1.1 9.7 0.0 2.5 2 1 0 2 2 2 0 AAA domain ABC_tran PF00005.27 CCF48955.1 - 0.15 12.6 0.5 0.24 11.9 0.5 1.9 1 1 0 1 1 1 0 ABC transporter RsgA_GTPase PF03193.16 CCF48955.1 - 2.9 7.8 5.0 5.1 7.0 1.1 2.6 2 1 1 3 3 3 0 RsgA GTPase Ribosomal_L23 PF00276.20 CCF48956.1 - 8.5e-06 26.0 0.0 2.8e-05 24.4 0.0 1.8 1 0 0 1 1 1 1 Ribosomal protein L23 Pkinase PF00069.25 CCF48957.1 - 8.7e-65 218.7 0.0 1.1e-64 218.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF48957.1 - 5.2e-34 117.7 0.0 7.4e-34 117.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCF48957.1 - 1.5e-08 34.3 0.0 2.5e-08 33.6 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 CCF48957.1 - 0.0002 21.4 0.5 0.00043 20.3 0.5 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 CCF48957.1 - 0.00025 20.5 0.2 0.00046 19.6 0.2 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 CCF48957.1 - 0.00099 18.1 0.1 0.0014 17.6 0.1 1.1 1 0 0 1 1 1 1 Haspin like kinase domain Pkinase_fungal PF17667.1 CCF48957.1 - 0.0017 17.2 0.0 0.0027 16.5 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Histidinol_dh PF00815.20 CCF48958.1 - 1.1e-156 522.0 0.4 1.1e-156 522.0 0.4 1.7 2 0 0 2 2 2 1 Histidinol dehydrogenase PRA-CH PF01502.18 CCF48958.1 - 8.6e-22 76.8 0.1 1.6e-21 75.9 0.1 1.5 1 0 0 1 1 1 1 Phosphoribosyl-AMP cyclohydrolase PRA-PH PF01503.17 CCF48958.1 - 7.7e-13 48.7 0.2 2e-12 47.4 0.2 1.7 1 0 0 1 1 1 1 Phosphoribosyl-ATP pyrophosphohydrolase MazG PF03819.17 CCF48958.1 - 0.041 14.1 0.1 0.089 13.0 0.1 1.6 1 0 0 1 1 1 0 MazG nucleotide pyrophosphohydrolase domain Peptidase_S10 PF00450.22 CCF48959.1 - 5.9e-93 312.5 0.0 1.3e-92 311.4 0.0 1.5 1 1 0 1 1 1 1 Serine carboxypeptidase CRAL_TRIO PF00650.20 CCF48960.1 - 3.1e-34 118.0 0.0 4.8e-34 117.4 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 CCF48960.1 - 1.7e-14 53.7 1.4 4.2e-14 52.5 1.4 1.7 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain Collagen PF01391.18 CCF48961.1 - 2.2e-07 30.5 34.7 4.5e-06 26.3 34.7 2.7 1 1 0 1 1 1 1 Collagen triple helix repeat (20 copies) SelP_N PF04592.14 CCF48962.1 - 0.75 9.2 12.7 1.4 8.3 12.7 1.4 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Zip PF02535.22 CCF48962.1 - 9.2 5.4 7.3 13 4.9 7.3 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter NUDIX PF00293.28 CCF48963.1 - 0.063 13.3 0.0 0.98 9.5 0.0 2.8 2 1 1 3 3 3 0 NUDIX domain Exo_endo_phos PF03372.23 CCF48964.1 - 1.4e-06 28.0 0.0 2.4e-06 27.2 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family WD40 PF00400.32 CCF48964.1 - 0.095 13.6 2.3 1.2 10.1 0.1 3.9 4 0 0 4 4 4 0 WD domain, G-beta repeat CN_hydrolase PF00795.22 CCF48965.1 - 3.8e-53 180.5 0.0 4.3e-53 180.3 0.0 1.0 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase SRP19 PF01922.17 CCF48967.1 - 2.7e-24 85.9 0.0 7.8e-24 84.4 0.0 1.8 2 0 0 2 2 2 1 SRP19 protein PolyA_pol PF01743.20 CCF48968.1 - 1e-21 77.7 0.0 2.1e-21 76.7 0.0 1.6 1 1 0 1 1 1 1 Poly A polymerase head domain PolyA_pol_RNAbd PF12627.7 CCF48968.1 - 1.4e-05 24.7 0.2 4.6e-05 23.1 0.2 1.8 1 0 0 1 1 1 1 Probable RNA and SrmB- binding site of polymerase A Y_phosphatase2 PF03162.13 CCF48969.1 - 3.4e-58 195.9 0.0 5.4e-58 195.2 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.6 CCF48969.1 - 2.4e-07 31.0 0.0 4.6e-07 30.0 0.0 1.4 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.20 CCF48969.1 - 0.0012 18.6 0.0 0.0024 17.7 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 CCF48969.1 - 0.0018 17.9 0.0 0.0028 17.2 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DUF2462 PF09495.10 CCF48970.1 - 2.3e-18 66.7 12.5 2.3e-18 66.7 12.5 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF2462) Cnd2 PF05786.14 CCF48971.1 - 2.4e-158 529.2 15.8 1.7e-157 526.4 15.6 2.1 1 1 0 1 1 1 1 Condensin complex subunit 2 CNDH2_N PF06278.11 CCF48971.1 - 0.014 15.6 1.6 0.024 14.8 0.0 2.2 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, N-terminal NDK PF00334.19 CCF48972.1 - 1.8e-32 112.2 0.0 2.4e-32 111.7 0.0 1.1 1 0 0 1 1 1 1 Nucleoside diphosphate kinase Spt20 PF12090.8 CCF48973.1 - 7.8e-33 114.0 0.0 3.7e-20 72.6 0.0 6.2 5 2 0 5 5 5 2 Spt20 family Dala_Dala_lig_N PF01820.21 CCF48973.1 - 5.2 7.6 7.0 24 5.5 0.6 2.9 2 1 0 2 2 2 0 D-ala D-ala ligase N-terminus AAA_23 PF13476.6 CCF48973.1 - 7.7 7.0 39.8 0.19 12.2 14.4 2.5 2 0 0 2 2 2 0 AAA domain adh_short PF00106.25 CCF48974.1 - 2.7e-41 141.2 0.5 3.2e-20 72.4 0.1 2.8 2 1 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CCF48974.1 - 2.7e-40 138.4 0.0 1.6e-22 80.2 0.0 2.7 2 1 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF48974.1 - 8.1e-05 22.6 0.1 0.00031 20.7 0.0 1.8 2 0 0 2 2 2 1 KR domain Epimerase PF01370.21 CCF48974.1 - 0.039 13.4 0.0 0.063 12.7 0.0 1.4 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family 2-Hacid_dh_C PF02826.19 CCF48974.1 - 0.11 11.9 0.0 0.16 11.3 0.0 1.2 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain YopE_N PF09020.10 CCF48976.1 - 0.0064 16.7 3.2 2.5 8.4 0.4 2.8 2 0 0 2 2 2 2 YopE, N terminal Pol_alpha_B_N PF08418.10 CCF48976.1 - 0.085 12.8 6.9 0.016 15.2 2.8 1.9 2 0 0 2 2 2 0 DNA polymerase alpha subunit B N-terminal BRAP2 PF07576.12 CCF48977.1 - 2e-26 92.1 0.1 3.7e-26 91.2 0.1 1.4 1 0 0 1 1 1 1 BRCA1-associated protein 2 zf-UBP PF02148.19 CCF48977.1 - 1.3e-18 67.0 5.2 1.3e-18 67.0 5.2 2.8 2 0 0 2 2 2 1 Zn-finger in ubiquitin-hydrolases and other protein zf-RING_2 PF13639.6 CCF48977.1 - 9e-08 32.3 10.1 9e-08 32.3 10.1 2.3 2 0 0 2 2 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 CCF48977.1 - 2.1e-06 27.5 9.5 1e-05 25.2 9.5 2.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CCF48977.1 - 1.3e-05 25.1 4.5 1.8e-05 24.7 2.9 2.1 1 1 0 1 1 1 1 RING-type zinc-finger Phage_GP20 PF06810.11 CCF48977.1 - 6.6e-05 22.7 10.0 0.00013 21.8 10.0 1.5 1 0 0 1 1 1 1 Phage minor structural protein GP20 zf-C3HC4 PF00097.25 CCF48977.1 - 0.00011 22.0 8.8 0.00011 22.0 8.8 2.1 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 CCF48977.1 - 0.00016 21.9 7.6 0.00016 21.9 7.6 2.9 4 0 0 4 4 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 CCF48977.1 - 0.00029 20.7 8.1 0.00029 20.7 8.1 2.7 3 0 0 3 3 3 1 zinc-RING finger domain zf-RING_11 PF17123.5 CCF48977.1 - 0.0003 20.5 5.4 0.0003 20.5 5.4 2.8 3 0 0 3 3 2 1 RING-like zinc finger zf-C3HC4_3 PF13920.6 CCF48977.1 - 0.0058 16.5 6.9 0.0058 16.5 6.9 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_4 PF14570.6 CCF48977.1 - 0.02 14.6 5.9 0.053 13.3 5.9 1.7 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain TSC22 PF01166.18 CCF48977.1 - 0.14 12.5 2.7 1.2 9.5 0.5 2.6 2 0 0 2 2 2 0 TSC-22/dip/bun family RRM_1 PF00076.22 CCF48977.1 - 0.14 12.0 0.0 0.3 10.9 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SelP_N PF04592.14 CCF48977.1 - 0.32 10.4 15.9 1.2 8.5 15.9 2.0 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Exonuc_VII_L PF02601.15 CCF48977.1 - 1.5 8.3 11.4 2.6 7.5 11.4 1.4 1 0 0 1 1 1 0 Exonuclease VII, large subunit TFIIA PF03153.13 CCF48977.1 - 1.8 8.5 26.8 0.33 10.9 17.1 2.4 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit SHE3 PF17078.5 CCF48977.1 - 3.6 7.3 22.3 13 5.5 10.5 2.8 2 1 1 3 3 3 0 SWI5-dependent HO expression protein 3 DUF4407 PF14362.6 CCF48977.1 - 3.8 6.8 15.5 7.3 5.8 15.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Aldo_ket_red PF00248.21 CCF48978.1 - 1.4e-50 172.1 0.1 1.2e-49 169.1 0.1 1.9 1 1 0 1 1 1 1 Aldo/keto reductase family TPP_enzyme_N PF02776.18 CCF48979.1 - 4.4e-33 114.3 0.0 8.5e-33 113.4 0.0 1.5 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.22 CCF48979.1 - 3.7e-24 85.0 0.0 8.1e-24 83.9 0.0 1.5 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.21 CCF48979.1 - 3.6e-14 52.8 0.0 1.2e-13 51.1 0.0 2.0 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain EF-hand_13 PF17958.1 CCF48979.1 - 0.07 12.9 0.0 0.17 11.7 0.0 1.6 1 0 0 1 1 1 0 EF-hand domain TauD PF02668.16 CCF48980.1 - 7.3e-54 183.3 0.2 9.8e-54 182.9 0.2 1.2 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family DUF4834 PF16118.5 CCF48981.1 - 0.0023 18.9 5.0 0.0025 18.8 5.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4834) Thymidylate_kin PF02223.17 CCF48981.1 - 0.012 15.3 1.1 0.013 15.2 1.1 1.1 1 0 0 1 1 1 0 Thymidylate kinase Connexin PF00029.19 CCF48981.1 - 0.023 14.5 3.0 0.024 14.4 3.0 1.0 1 0 0 1 1 1 0 Connexin Presenilin PF01080.17 CCF48981.1 - 0.03 13.1 5.9 0.032 13.0 5.9 1.0 1 0 0 1 1 1 0 Presenilin FHIPEP PF00771.20 CCF48981.1 - 0.04 12.4 1.8 0.038 12.5 1.8 1.0 1 0 0 1 1 1 0 FHIPEP family Ureide_permease PF07168.11 CCF48981.1 - 0.046 12.5 0.5 0.05 12.4 0.5 1.0 1 0 0 1 1 1 0 Ureide permease ABC2_membrane_2 PF12679.7 CCF48981.1 - 0.054 12.8 1.2 0.057 12.7 1.2 1.0 1 0 0 1 1 1 0 ABC-2 family transporter protein DUF1980 PF09323.10 CCF48981.1 - 0.068 13.1 2.1 0.073 13.0 2.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) MTABC_N PF16185.5 CCF48981.1 - 0.074 12.5 1.0 0.087 12.3 1.0 1.1 1 0 0 1 1 1 0 Mitochondrial ABC-transporter N-terminal five TM region OATP PF03137.20 CCF48981.1 - 0.087 11.1 2.6 0.087 11.1 2.6 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Folate_carrier PF01770.18 CCF48981.1 - 0.1 11.3 4.8 0.11 11.2 4.8 1.0 1 0 0 1 1 1 0 Reduced folate carrier Dpy19 PF10034.9 CCF48981.1 - 0.1 10.8 4.6 0.11 10.7 4.6 1.0 1 0 0 1 1 1 0 Q-cell neuroblast polarisation CLN3 PF02487.17 CCF48981.1 - 0.21 10.6 3.6 0.22 10.5 3.6 1.0 1 0 0 1 1 1 0 CLN3 protein CSG2 PF16965.5 CCF48981.1 - 0.26 10.2 1.5 0.27 10.1 1.5 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator EIIBC-GUT_N PF03612.14 CCF48981.1 - 0.36 10.5 5.3 0.35 10.6 5.3 1.1 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Suf PF05843.14 CCF48981.1 - 0.48 10.4 14.5 0.5 10.3 14.5 1.0 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Pex14_N PF04695.13 CCF48981.1 - 8.6 7.0 19.5 9.4 6.9 19.5 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Uds1 PF15456.6 CCF48984.1 - 0.0077 16.4 9.3 0.052 13.7 3.1 2.4 2 0 0 2 2 2 2 Up-regulated During Septation DUF4140 PF13600.6 CCF48984.1 - 0.013 15.9 3.4 2 8.9 0.6 2.6 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) CAF20 PF17052.5 CCF48984.1 - 4.6 7.4 7.5 0.87 9.7 2.3 2.2 2 1 0 2 2 2 0 Cap associated factor AAA_23 PF13476.6 CCF48984.1 - 7.4 7.0 6.3 7.3 7.0 2.3 2.1 2 0 0 2 2 2 0 AAA domain TP_methylase PF00590.20 CCF48985.1 - 1.5e-38 132.9 0.1 3.1e-38 131.9 0.1 1.5 1 0 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases NAD_binding_7 PF13241.6 CCF48985.1 - 1.8e-11 44.4 0.0 4.8e-05 23.7 0.0 2.5 2 0 0 2 2 2 2 Putative NAD(P)-binding Sirohm_synth_M PF14824.6 CCF48985.1 - 8.5e-10 37.9 0.2 1.8e-09 36.8 0.2 1.6 1 0 0 1 1 1 1 Sirohaem biosynthesis protein central Sirohm_synth_C PF14823.6 CCF48985.1 - 2.7e-09 36.5 1.3 1.3e-06 27.9 0.4 2.5 2 0 0 2 2 2 2 Sirohaem biosynthesis protein C-terminal LEAP-2 PF07359.11 CCF48985.1 - 0.13 12.1 0.9 0.35 10.7 0.0 2.1 2 0 0 2 2 2 0 Liver-expressed antimicrobial peptide 2 precursor (LEAP-2) COX17 PF05051.13 CCF48986.1 - 3.4e-19 68.9 6.5 5.2e-19 68.3 6.5 1.3 1 0 0 1 1 1 1 Cytochrome C oxidase copper chaperone (COX17) UPF0203 PF05254.12 CCF48986.1 - 0.0026 18.0 2.0 0.0035 17.6 2.0 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0203) Peptidase_M16_C PF05193.21 CCF48987.1 - 1.6e-16 60.9 0.0 5.7e-12 46.0 0.0 3.0 2 1 0 2 2 2 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 CCF48987.1 - 7.3e-07 29.3 0.1 4.8e-06 26.6 0.0 2.2 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) Sdh_cyt PF01127.22 CCF48988.1 - 9.2e-23 80.6 4.5 1.4e-22 80.0 4.5 1.3 1 0 0 1 1 1 1 Succinate dehydrogenase/Fumarate reductase transmembrane subunit Exonuc_VII_L PF02601.15 CCF48989.1 - 0.5 9.9 20.0 9.6 5.7 20.0 2.1 1 1 0 1 1 1 0 Exonuclease VII, large subunit DUF2524 PF10732.9 CCF48989.1 - 3.1 8.1 10.9 2.4 8.5 6.8 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF2524) DNApol_Exo PF18136.1 CCF48990.1 - 6.4e-87 291.3 0.0 1e-77 261.0 0.0 2.6 2 0 0 2 2 2 2 DNA mitochondrial polymerase exonuclease domain DNA_pol_A PF00476.20 CCF48990.1 - 5.4e-49 167.2 0.0 1e-48 166.3 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase family A Complex1_LYR_2 PF13233.6 CCF48990.1 - 0.011 16.5 2.5 0.055 14.2 0.1 2.7 2 0 0 2 2 2 0 Complex1_LYR-like DUF5304 PF17230.2 CCF48990.1 - 0.082 13.1 2.4 0.083 13.1 0.4 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5304) DNA_pol_B_exo2 PF10108.9 CCF48990.1 - 0.14 11.8 0.0 3.3 7.3 0.0 2.3 2 0 0 2 2 2 0 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB Urease_alpha PF00449.20 CCF48991.1 - 3.2e-55 185.6 0.4 6.1e-55 184.7 0.4 1.5 1 0 0 1 1 1 1 Urease alpha-subunit, N-terminal domain Amidohydro_1 PF01979.20 CCF48991.1 - 2.5e-53 181.6 1.0 6e-53 180.4 1.0 1.6 1 1 0 1 1 1 1 Amidohydrolase family Urease_gamma PF00547.18 CCF48991.1 - 1.8e-40 137.3 0.1 3.7e-40 136.2 0.1 1.6 1 0 0 1 1 1 1 Urease, gamma subunit Urease_beta PF00699.20 CCF48991.1 - 1.7e-35 120.9 0.0 5.1e-35 119.4 0.0 1.9 1 0 0 1 1 1 1 Urease beta subunit Flavin_Reduct PF01613.18 CCF48992.1 - 3.6e-32 111.5 1.1 3.9e-32 111.4 0.1 1.5 2 0 0 2 2 2 1 Flavin reductase like domain Abhydrolase_1 PF00561.20 CCF48993.1 - 1.7e-38 132.7 0.0 1.1e-37 130.1 0.0 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Esterase PF00756.20 CCF48993.1 - 0.093 12.4 0.1 0.16 11.6 0.1 1.3 1 0 0 1 1 1 0 Putative esterase Hydrolase_4 PF12146.8 CCF48993.1 - 0.15 11.3 0.1 1.3 8.2 0.1 2.0 2 0 0 2 2 2 0 Serine aminopeptidase, S33 GAF_2 PF13185.6 CCF48994.1 - 0.032 14.5 0.2 6.5 7.0 0.0 2.2 2 0 0 2 2 2 0 GAF domain Seipin PF06775.14 CCF48995.1 - 1.2e-50 172.3 0.0 2.4e-50 171.4 0.0 1.5 1 0 0 1 1 1 1 Putative adipose-regulatory protein (Seipin) UPF0242 PF06785.11 CCF48995.1 - 0.0015 18.7 0.4 0.0015 18.7 0.4 1.8 2 0 0 2 2 2 1 Uncharacterised protein family (UPF0242) N-terminus DUF4834 PF16118.5 CCF48995.1 - 0.8 10.7 6.3 1.1 10.3 0.2 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Glyco_hydro_92 PF07971.12 CCF48997.1 - 1.8e-114 383.2 0.0 2.1e-114 383.0 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 Glyco_hydro_92N PF17678.1 CCF48997.1 - 9.2e-32 110.8 0.0 1.6e-31 110.1 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 N-terminal domain Aldo_ket_red PF00248.21 CCF48998.1 - 4.5e-32 111.4 0.0 9.4e-32 110.4 0.0 1.5 1 1 0 1 1 1 1 Aldo/keto reductase family TAP42 PF04177.12 CCF48999.1 - 3.2e-72 243.4 0.1 4.1e-72 243.0 0.1 1.1 1 0 0 1 1 1 1 TAP42-like family RCDG1 PF15725.5 CCF48999.1 - 8.3 6.9 15.8 2.5 8.6 1.0 2.6 2 0 0 2 2 2 0 Renal cancer differentiation gene 1 protein Ribosomal_L10 PF00466.20 CCF49001.1 - 8e-25 86.9 0.0 2e-24 85.6 0.0 1.6 2 0 0 2 2 2 1 Ribosomal protein L10 Ribosomal_60s PF00428.19 CCF49001.1 - 5.7e-22 78.1 8.6 5.7e-22 78.1 8.6 2.0 2 0 0 2 2 2 1 60s Acidic ribosomal protein RL10P_insert PF17777.1 CCF49001.1 - 1.3e-20 73.2 0.0 2.2e-20 72.4 0.0 1.4 1 0 0 1 1 1 1 Insertion domain in 60S ribosomal protein L10P LIM PF00412.22 CCF49002.1 - 1.2e-10 41.5 41.2 0.00018 21.7 2.1 6.5 6 0 0 6 6 6 4 LIM domain NinD PF17466.2 CCF49002.1 - 4.2 7.5 9.1 8.6 6.5 0.6 3.9 3 0 0 3 3 3 0 Family of unknown function zf-FPG_IleRS PF06827.14 CCF49002.1 - 9.1 6.3 11.1 17 5.3 0.7 4.4 3 0 0 3 3 3 0 Zinc finger found in FPG and IleRS GDP_Man_Dehyd PF16363.5 CCF49003.1 - 1.3e-44 153.0 0.0 1.5e-44 152.8 0.0 1.1 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 CCF49003.1 - 6.2e-43 147.0 0.0 8.3e-43 146.6 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 CCF49003.1 - 2.1e-12 46.6 0.0 9.3e-11 41.2 0.0 2.1 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 CCF49003.1 - 5.1e-10 38.9 0.0 9e-10 38.1 0.0 1.4 1 1 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 CCF49003.1 - 8.5e-08 31.7 0.0 5.5e-07 29.0 0.0 2.0 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.12 CCF49003.1 - 3.4e-06 26.4 0.0 7.6e-06 25.3 0.0 1.5 1 1 0 1 1 1 1 Male sterility protein NAD_binding_10 PF13460.6 CCF49003.1 - 4.2e-05 23.5 0.0 0.00018 21.5 0.0 2.1 1 1 0 1 1 1 1 NAD(P)H-binding KR PF08659.10 CCF49003.1 - 0.0062 16.5 0.0 0.015 15.3 0.0 1.6 1 1 0 1 1 1 1 KR domain 3HCDH_N PF02737.18 CCF49003.1 - 0.036 13.9 0.0 0.067 13.1 0.0 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain PrpF PF04303.13 CCF49004.1 - 6.2e-53 180.1 0.2 5.3e-34 117.8 0.1 3.2 2 1 0 2 2 2 2 PrpF protein Acyltransferase PF01553.21 CCF49005.1 - 4.5e-23 81.4 0.0 7.5e-23 80.6 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase Acyltransf_C PF16076.5 CCF49005.1 - 0.00014 21.9 0.3 0.00031 20.8 0.3 1.5 1 0 0 1 1 1 1 Acyltransferase C-terminus AIM5 PF17050.5 CCF49006.1 - 9.4e-08 32.8 0.4 1.9e-07 31.8 0.4 1.5 1 0 0 1 1 1 1 Altered inheritance of mitochondria 5 NatB_MDM20 PF09797.9 CCF49007.1 - 2.1e-95 319.9 7.9 5.1e-95 318.6 7.1 2.0 2 0 0 2 2 2 1 N-acetyltransferase B complex (NatB) non catalytic subunit TPR_19 PF14559.6 CCF49007.1 - 9e-05 22.9 11.4 1.2 9.6 0.1 4.7 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_5 PF12688.7 CCF49007.1 - 0.036 14.3 3.7 0.1 12.9 0.5 3.4 3 1 0 3 3 3 0 Tetratrico peptide repeat ANAPC3 PF12895.7 CCF49007.1 - 0.071 13.4 4.1 6.6 7.0 0.0 3.6 4 0 0 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 DUF1708 PF08101.11 CCF49008.1 - 7.1e-16 58.4 0.0 3.4e-11 43.0 0.0 2.6 3 0 0 3 3 3 2 Domain of unknown function (DUF1708) RhoGAP PF00620.27 CCF49008.1 - 4e-08 33.2 0.0 9.7e-06 25.5 0.0 2.4 2 0 0 2 2 2 2 RhoGAP domain Pyridoxal_deC PF00282.19 CCF49009.1 - 1.3e-66 224.8 0.0 2e-66 224.2 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.19 CCF49009.1 - 0.0053 15.8 0.0 0.0094 14.9 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V DUF809 PF05663.11 CCF49010.1 - 2.1 8.5 6.1 5.2 7.2 6.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF809) MTHFR PF02219.17 CCF49011.1 - 2.5e-100 335.5 0.0 8.2e-83 278.0 0.0 2.1 2 0 0 2 2 2 2 Methylenetetrahydrofolate reductase pPIWI_RE_REase PF18154.1 CCF49011.1 - 0.074 13.0 0.1 0.66 10.0 0.0 2.2 2 0 0 2 2 2 0 REase associating with pPIWI_RE PLDc_2 PF13091.6 CCF49012.1 - 3.1e-19 69.2 0.0 9e-14 51.5 0.0 2.7 3 0 0 3 3 3 2 PLD-like domain PLDc PF00614.22 CCF49012.1 - 0.026 14.7 0.1 0.17 12.1 0.0 2.2 2 0 0 2 2 2 0 Phospholipase D Active site motif Dicty_REP PF05086.12 CCF49012.1 - 2.5 5.9 6.2 3.8 5.4 6.2 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DUF3439 PF11921.8 CCF49012.1 - 7.6 6.5 6.6 17 5.4 6.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Cpn60_TCP1 PF00118.24 CCF49013.1 - 7.9e-165 549.2 4.7 8.9e-165 549.0 4.7 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Methyltr_RsmB-F PF01189.17 CCF49015.1 - 2.9e-15 56.4 0.0 8.7e-09 35.3 0.0 2.5 2 0 0 2 2 2 2 16S rRNA methyltransferase RsmB/F PGA2 PF07543.12 CCF49015.1 - 2.5 8.1 12.3 5.1 7.1 12.3 1.5 1 0 0 1 1 1 0 Protein trafficking PGA2 Pyrophosphatase PF00719.19 CCF49016.1 - 9e-60 201.1 0.3 1.2e-59 200.7 0.3 1.1 1 0 0 1 1 1 1 Inorganic pyrophosphatase HAMP PF00672.25 CCF49016.1 - 0.095 13.1 0.1 0.16 12.4 0.1 1.3 1 0 0 1 1 1 0 HAMP domain COesterase PF00135.28 CCF49017.1 - 1e-83 282.0 0.0 1.3e-83 281.6 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 CCF49017.1 - 3.8e-09 36.7 3.2 0.0008 19.3 0.1 2.7 3 0 0 3 3 3 2 alpha/beta hydrolase fold OTU PF02338.19 CCF49018.1 - 1.3e-07 32.1 0.0 2.6e-07 31.2 0.0 1.5 1 0 0 1 1 1 1 OTU-like cysteine protease Glyco_hydro_3_C PF01915.22 CCF49019.1 - 9.8e-42 143.2 0.0 1.7e-41 142.4 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 CCF49019.1 - 8.9e-27 94.3 0.0 2.1e-20 73.4 0.0 2.3 1 1 0 2 2 2 2 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 CCF49019.1 - 3.2e-24 84.8 0.3 6e-24 84.0 0.3 1.5 1 0 0 1 1 1 1 Fibronectin type III-like domain Sugar_tr PF00083.24 CCF49020.1 - 1.1e-107 360.7 24.6 1.6e-107 360.2 24.6 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF49020.1 - 5e-28 98.0 34.6 4e-27 95.1 29.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily OST3_OST6 PF04756.13 CCF49020.1 - 0.47 9.7 2.1 1.2 8.4 2.1 1.6 1 0 0 1 1 1 0 OST3 / OST6 family, transporter family FAD_binding_7 PF03441.14 CCF49021.1 - 8.2e-73 244.2 0.3 1.2e-72 243.7 0.3 1.2 1 0 0 1 1 1 1 FAD binding domain of DNA photolyase DNA_photolyase PF00875.18 CCF49021.1 - 2.5e-43 147.9 0.0 4.3e-43 147.1 0.0 1.4 1 0 0 1 1 1 1 DNA photolyase Pribosyltran_N PF13793.6 CCF49022.1 - 1.2e-44 150.9 0.2 4.3e-44 149.2 0.0 1.9 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.6 CCF49022.1 - 2e-39 135.5 2.3 1.5e-32 113.2 0.3 2.7 2 1 1 3 3 3 2 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.27 CCF49022.1 - 5.3e-14 52.0 2.0 1.4e-13 50.7 0.3 2.3 2 1 1 3 3 3 1 Phosphoribosyl transferase domain DUF2007 PF09413.10 CCF49022.1 - 0.085 13.0 0.0 0.23 11.7 0.0 1.7 1 0 0 1 1 1 0 Putative prokaryotic signal transducing protein Pil1 PF13805.6 CCF49023.1 - 9.1e-28 97.5 4.3 1.5e-27 96.7 4.3 1.3 1 0 0 1 1 1 1 Eisosome component PIL1 GrpE PF01025.19 CCF49023.1 - 0.012 15.3 0.8 0.024 14.3 0.8 1.5 1 0 0 1 1 1 0 GrpE FmiP_Thoc5 PF09766.9 CCF49023.1 - 0.055 12.8 3.4 0.086 12.1 3.4 1.2 1 0 0 1 1 1 0 Fms-interacting protein/Thoc5 DUF1664 PF07889.12 CCF49023.1 - 0.11 12.5 2.3 0.2 11.7 1.2 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) Vps51 PF08700.11 CCF49023.1 - 0.12 12.5 1.1 0.31 11.1 1.1 1.7 1 0 0 1 1 1 0 Vps51/Vps67 ATG16 PF08614.11 CCF49023.1 - 0.21 11.8 6.9 0.61 10.3 6.9 1.7 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) TMF_TATA_bd PF12325.8 CCF49023.1 - 0.27 11.5 4.0 0.5 10.6 3.5 1.6 1 1 0 1 1 1 0 TATA element modulatory factor 1 TATA binding AAA_13 PF13166.6 CCF49023.1 - 0.29 9.7 4.5 0.4 9.3 4.5 1.1 1 0 0 1 1 1 0 AAA domain Gp-FAR-1 PF05823.12 CCF49023.1 - 1.1 9.6 3.9 0.69 10.3 1.0 2.0 2 1 0 2 2 2 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) DUF2730 PF10805.8 CCF49023.1 - 1.7 8.8 3.6 0.62 10.2 0.6 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2730) NIPSNAP PF07978.13 CCF49024.1 - 7.5e-40 135.3 0.9 2e-28 98.6 0.2 2.3 2 0 0 2 2 2 2 NIPSNAP Pyridoxal_deC PF00282.19 CCF49025.1 - 2.2e-87 293.2 0.0 5.1e-56 190.0 0.0 2.1 2 0 0 2 2 2 2 Pyridoxal-dependent decarboxylase conserved domain BCDHK_Adom3 PF10436.9 CCF49026.1 - 3.7e-43 147.2 0.0 5.3e-43 146.7 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 CCF49026.1 - 7.4e-09 36.1 0.0 5.2e-08 33.4 0.0 2.2 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 CCF49026.1 - 1.2e-05 25.2 0.0 2.2e-05 24.3 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Gpr1_Fun34_YaaH PF01184.19 CCF49027.1 - 7.5e-41 140.0 14.2 9.3e-41 139.7 14.2 1.0 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family Gpr1_Fun34_YaaH PF01184.19 CCF49029.1 - 2.5e-72 242.9 18.0 3e-72 242.6 18.0 1.1 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family adh_short PF00106.25 CCF49030.1 - 3.4e-28 98.5 0.1 6e-28 97.6 0.1 1.4 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF49030.1 - 7.5e-19 68.2 0.1 3e-18 66.3 0.1 1.8 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 CCF49030.1 - 0.0056 16.2 0.5 0.016 14.6 0.1 1.9 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family KR PF08659.10 CCF49030.1 - 0.013 15.4 6.4 0.02 14.8 2.0 2.6 2 1 0 2 2 2 0 KR domain AAA PF00004.29 CCF49032.1 - 2.3e-15 57.2 0.0 5.2e-15 56.0 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 CCF49032.1 - 4.5e-11 43.4 0.0 6.5e-10 39.6 0.0 2.6 2 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 CCF49032.1 - 1.6e-07 31.7 0.0 3.7e-07 30.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_lid_10 PF17872.1 CCF49032.1 - 1.8e-06 27.9 0.2 5.7e-06 26.4 0.2 1.8 1 0 0 1 1 1 1 AAA lid domain AAA_19 PF13245.6 CCF49032.1 - 0.00052 20.4 0.0 0.0042 17.4 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.6 CCF49032.1 - 0.0089 15.8 0.1 0.042 13.6 0.0 2.0 2 0 0 2 2 2 1 AAA domain Cdc6_C PF09079.11 CCF49032.1 - 0.0094 15.9 0.1 0.068 13.1 0.1 2.6 1 1 0 1 1 1 1 CDC6, C terminal winged helix domain Viral_helicase1 PF01443.18 CCF49032.1 - 0.038 13.7 0.0 0.11 12.2 0.0 1.8 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase PIF1 PF05970.14 CCF49032.1 - 0.051 12.8 0.1 0.11 11.7 0.0 1.5 2 0 0 2 2 2 0 PIF1-like helicase NACHT PF05729.12 CCF49032.1 - 0.06 13.3 0.0 0.18 11.7 0.0 1.8 1 1 0 1 1 1 0 NACHT domain AAA_30 PF13604.6 CCF49032.1 - 0.061 13.0 0.2 0.15 11.8 0.2 1.7 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 CCF49032.1 - 0.11 12.7 0.0 0.43 10.7 0.0 2.1 2 0 0 2 2 2 0 AAA domain MeaB PF03308.16 CCF49032.1 - 0.11 11.5 0.0 1.2 8.0 0.0 2.2 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Glyco_transf_22 PF03901.17 CCF49033.1 - 2e-64 218.4 24.4 2.8e-63 214.6 22.3 2.1 2 0 0 2 2 2 2 Alg9-like mannosyltransferase family DUF2955 PF11168.8 CCF49033.1 - 0.46 10.3 7.1 1.3 8.8 0.7 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2955) SPC25 PF06703.11 CCF49034.1 - 4.5e-45 153.3 0.0 5.4e-45 153.1 0.0 1.1 1 0 0 1 1 1 1 Microsomal signal peptidase 25 kDa subunit (SPC25) RRM_1 PF00076.22 CCF49035.1 - 5.9e-12 45.2 0.0 1.1e-11 44.3 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Rtf2 PF04641.12 CCF49035.1 - 1.3 8.4 8.8 1.9 7.8 8.8 1.4 1 0 0 1 1 1 0 Rtf2 RING-finger DUF1682 PF07946.14 CCF49035.1 - 2.7 7.1 9.9 4.4 6.4 9.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) DUF2417 PF10329.9 CCF49036.1 - 1.8e-13 50.5 0.1 2.7e-13 49.9 0.1 1.3 1 0 0 1 1 1 1 Region of unknown function (DUF2417) Phage_ASH PF10554.9 CCF49036.1 - 0.051 13.9 0.0 0.4 11.0 0.0 2.2 1 1 1 2 2 2 0 Ash protein family Nuc_sug_transp PF04142.15 CCF49037.1 - 5.3e-80 268.9 13.5 8.7e-69 232.1 11.2 2.9 2 1 0 2 2 2 2 Nucleotide-sugar transporter UAA PF08449.11 CCF49037.1 - 3.6e-05 23.1 12.0 0.0011 18.3 0.4 2.3 2 1 0 2 2 2 2 UAA transporter family EamA PF00892.20 CCF49037.1 - 0.0018 18.5 1.8 0.0018 18.5 1.8 2.5 2 0 0 2 2 2 1 EamA-like transporter family zf-C2H2_4 PF13894.6 CCF49038.1 - 2.5e-06 27.8 3.0 0.0041 17.8 0.1 2.4 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.26 CCF49038.1 - 7.7e-06 26.1 2.5 0.027 14.9 0.1 2.4 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 CCF49038.1 - 3.1e-05 24.1 1.4 0.00046 20.4 0.6 2.4 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.12 CCF49038.1 - 0.0035 17.6 1.3 0.32 11.3 1.4 2.2 1 1 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding Ima1_N PF09779.9 CCF49038.1 - 0.04 14.8 0.1 0.057 14.3 0.1 1.3 1 0 0 1 1 1 0 Ima1 N-terminal domain zf-C2H2_6 PF13912.6 CCF49038.1 - 0.063 13.3 0.5 2.7 8.1 0.1 2.4 1 1 1 2 2 2 0 C2H2-type zinc finger HypA PF01155.19 CCF49038.1 - 0.086 12.9 0.2 0.14 12.2 0.2 1.3 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DUF2844 PF11005.8 CCF49038.1 - 0.11 12.5 0.1 0.86 9.6 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2844) zf-H2C2_2 PF13465.6 CCF49038.1 - 3.4 8.3 6.6 1.7 9.2 0.5 2.8 4 0 0 4 4 4 0 Zinc-finger double domain MCCD1 PF15707.5 CCF49039.1 - 0.027 14.9 0.1 0.073 13.5 0.1 1.7 1 0 0 1 1 1 0 Mitochondrial coiled-coil domain protein 1 Rrn6 PF10214.9 CCF49040.1 - 3e-12 45.9 27.2 7.5e-09 34.7 12.1 3.1 2 1 1 3 3 3 2 RNA polymerase I-specific transcription-initiation factor zf-3CxxC PF13695.6 CCF49041.1 - 0.0027 18.2 1.7 0.006 17.0 1.7 1.6 1 0 0 1 1 1 1 Zinc-binding domain Peptidase_M16 PF00675.20 CCF49042.1 - 1.7e-07 31.3 0.4 0.02 14.9 0.0 3.1 1 1 2 3 3 3 2 Insulinase (Peptidase family M16) Vps16_C PF04840.12 CCF49043.1 - 1.6e-05 24.2 0.1 3e-05 23.2 0.0 1.5 2 0 0 2 2 2 1 Vps16, C-terminal region Iso_dh PF00180.20 CCF49043.1 - 0.0047 16.1 0.0 0.01 15.0 0.0 1.4 2 0 0 2 2 2 1 Isocitrate/isopropylmalate dehydrogenase TRP PF06011.12 CCF49045.1 - 0.087 11.5 0.2 0.15 10.7 0.2 1.4 1 0 0 1 1 1 0 Transient receptor potential (TRP) ion channel Peptidase_M36 PF02128.15 CCF49046.1 - 1.1e-148 495.3 1.1 1.3e-148 495.1 0.4 1.5 2 0 0 2 2 2 1 Fungalysin metallopeptidase (M36) FTP PF07504.13 CCF49046.1 - 1.7e-11 43.7 0.0 3.4e-11 42.8 0.0 1.5 1 0 0 1 1 1 1 Fungalysin/Thermolysin Propeptide Motif cwf21 PF08312.12 CCF49046.1 - 0.023 14.9 0.0 0.053 13.7 0.0 1.6 1 0 0 1 1 1 0 cwf21 domain Peptidase_M4_C PF02868.15 CCF49046.1 - 0.055 13.3 0.1 0.13 12.2 0.1 1.5 1 0 0 1 1 1 0 Thermolysin metallopeptidase, alpha-helical domain Nup188 PF10487.9 CCF49047.1 - 8.8e-33 113.3 0.0 2.3e-18 65.6 0.0 2.6 2 0 0 2 2 2 2 Nucleoporin subcomplex protein binding to Pom34 Nup188_C PF18378.1 CCF49047.1 - 0.44 9.3 7.2 0.06 12.2 2.3 2.0 2 1 0 2 2 2 0 Nuclear pore protein NUP188 C-terminal domain Abhydrolase_6 PF12697.7 CCF49048.1 - 0.0029 18.2 0.0 0.0044 17.7 0.0 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family ThiF PF00899.21 CCF49049.1 - 1.1e-64 218.1 0.0 1.5e-64 217.7 0.0 1.2 1 0 0 1 1 1 1 ThiF family E2_bind PF08825.10 CCF49049.1 - 1.9e-24 85.6 0.0 3.1e-24 84.9 0.0 1.3 1 0 0 1 1 1 1 E2 binding domain Shikimate_DH PF01488.20 CCF49049.1 - 0.035 14.2 0.0 0.079 13.0 0.0 1.6 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase PglD_N PF17836.1 CCF49049.1 - 0.11 13.1 0.1 0.3 11.7 0.1 1.7 1 0 0 1 1 1 0 PglD N-terminal domain Cellulase PF00150.18 CCF49050.1 - 1.4e-16 60.7 4.3 3.3e-16 59.6 4.3 1.6 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) GRP PF07172.11 CCF49050.1 - 0.1 13.3 2.2 0.13 13.0 0.1 2.0 2 0 0 2 2 2 0 Glycine rich protein family PI3_PI4_kinase PF00454.27 CCF49051.1 - 4.9e-30 105.2 0.3 5.5e-21 75.5 0.4 2.4 1 1 1 2 2 2 2 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 CCF49051.1 - 2.2e-24 85.9 0.6 4.2e-24 85.0 0.6 1.4 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) Ras PF00071.22 CCF49052.1 - 9.8e-60 200.8 1.0 1.3e-59 200.5 1.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CCF49052.1 - 1.7e-37 128.3 0.1 2.9e-37 127.6 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CCF49052.1 - 5.9e-16 58.4 0.2 7.7e-16 58.0 0.2 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 CCF49052.1 - 1.2e-06 28.2 0.4 6.9e-06 25.7 0.4 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 CCF49052.1 - 5.6e-06 25.9 0.1 8e-06 25.4 0.1 1.3 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit RsgA_GTPase PF03193.16 CCF49052.1 - 1.3e-05 25.2 0.1 0.018 15.0 0.1 2.2 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 CCF49052.1 - 2.3e-05 24.5 0.1 5.4e-05 23.2 0.1 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 CCF49052.1 - 4.7e-05 22.9 0.4 6e-05 22.5 0.4 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region FeoB_N PF02421.18 CCF49052.1 - 0.0083 15.7 0.4 0.23 11.0 0.4 2.2 1 1 0 1 1 1 1 Ferrous iron transport protein B FlgH PF02107.16 CCF49052.1 - 0.013 15.2 0.5 0.018 14.7 0.5 1.2 1 0 0 1 1 1 0 Flagellar L-ring protein DUF2514 PF10721.9 CCF49052.1 - 0.02 14.9 0.2 0.028 14.4 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2514) AAA_28 PF13521.6 CCF49052.1 - 0.033 14.4 0.1 2.2 8.5 0.1 2.1 1 1 0 1 1 1 0 AAA domain TniB PF05621.11 CCF49052.1 - 0.067 12.6 0.0 1.2 8.5 0.0 2.2 2 0 0 2 2 2 0 Bacterial TniB protein Dynamin_N PF00350.23 CCF49052.1 - 0.094 12.8 0.1 9.6 6.2 0.0 2.6 2 1 1 3 3 3 0 Dynamin family TetR_C_16 PF17920.1 CCF49052.1 - 0.11 12.7 0.0 0.26 11.5 0.0 1.6 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain Transket_pyr PF02779.24 CCF49053.1 - 1.5e-44 151.8 0.0 2.6e-44 151.0 0.0 1.4 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 CCF49053.1 - 1.3e-36 125.2 0.2 2.8e-36 124.1 0.2 1.6 1 0 0 1 1 1 1 Transketolase, C-terminal domain DUF900 PF05990.12 CCF49053.1 - 0.043 13.3 0.0 0.066 12.7 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) CK_II_beta PF01214.18 CCF49054.1 - 5.5e-82 274.0 0.0 7.6e-82 273.5 0.0 1.2 1 0 0 1 1 1 1 Casein kinase II regulatory subunit PNP_UDP_1 PF01048.20 CCF49055.1 - 6.4e-30 104.1 0.0 1.5e-29 102.9 0.0 1.7 1 1 0 1 1 1 1 Phosphorylase superfamily SLATT_fungal PF18142.1 CCF49056.1 - 0.045 13.7 0.4 0.12 12.4 0.1 1.8 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain G-gamma PF00631.22 CCF49057.1 - 4.3e-25 87.5 0.0 4.8e-25 87.4 0.0 1.0 1 0 0 1 1 1 1 GGL domain DUF5595 PF18077.1 CCF49057.1 - 0.19 11.8 0.4 0.32 11.1 0.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5595) Iso_dh PF00180.20 CCF49058.1 - 1.3e-74 251.4 0.0 1.6e-74 251.2 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Iso_dh PF00180.20 CCF49059.1 - 8.7e-75 252.0 0.0 1e-74 251.8 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase PSD1 PF07587.11 CCF49060.1 - 0.00018 21.1 1.2 0.26 10.7 0.1 2.9 2 1 1 3 3 3 2 Protein of unknown function (DUF1553) TTRAP PF14203.6 CCF49060.1 - 0.023 14.7 0.0 34 4.5 0.0 3.1 2 1 1 3 3 3 0 Putative tranposon-transfer assisting protein Mt_ATP_synt PF15704.5 CCF49060.1 - 0.03 14.2 0.2 8.4 6.2 0.1 2.1 1 1 1 2 2 2 0 Mitochondrial ATP synthase subunit DUF896 PF05979.12 CCF49060.1 - 0.08 12.8 0.0 24 4.9 0.0 2.8 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF896) FANC_SAP PF18081.1 CCF49060.1 - 0.81 9.9 3.6 1.4 9.2 0.2 2.7 2 1 1 3 3 3 0 Fanconi anemia-associated nuclease SAP domain DUF5437 PF17505.2 CCF49060.1 - 2.7 8.1 5.5 38 4.4 0.3 3.5 2 2 1 3 3 3 0 Family of unknown function (DUF5437) Chitin_synth_2 PF03142.15 CCF49061.1 - 1.9e-19 69.7 3.9 6.7e-18 64.6 0.6 2.8 2 2 1 3 3 3 2 Chitin synthase Glyco_trans_2_3 PF13632.6 CCF49061.1 - 1.1e-05 25.4 5.0 1.1e-05 25.4 5.0 1.8 2 0 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 CCF49061.1 - 0.042 13.7 0.9 0.98 9.2 0.2 2.4 2 0 0 2 2 2 0 Glycosyltransferase like family 2 UDPG_MGDP_dh PF00984.19 CCF49062.1 - 1.3e-19 70.2 0.0 4e-19 68.6 0.0 1.9 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain UDPG_MGDP_dh_N PF03721.14 CCF49062.1 - 7.4e-17 61.5 0.0 7.2e-15 55.0 0.0 2.9 2 1 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain UDPG_MGDP_dh_C PF03720.15 CCF49062.1 - 5.7e-05 23.5 0.3 0.00035 21.0 0.0 2.4 3 0 0 3 3 3 1 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain Methyltransf_25 PF13649.6 CCF49062.1 - 0.00022 21.9 0.1 0.003 18.2 0.0 2.5 2 0 0 2 2 2 1 Methyltransferase domain NAD_binding_2 PF03446.15 CCF49062.1 - 0.0013 18.9 0.0 0.0037 17.5 0.0 1.8 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase TrkA_N PF02254.18 CCF49062.1 - 0.0022 18.3 0.0 0.006 16.8 0.0 1.8 1 0 0 1 1 1 1 TrkA-N domain GFO_IDH_MocA PF01408.22 CCF49062.1 - 0.0068 17.2 0.5 0.071 13.9 0.0 2.7 2 1 0 3 3 3 1 Oxidoreductase family, NAD-binding Rossmann fold Sacchrp_dh_NADP PF03435.18 CCF49062.1 - 0.062 13.6 0.0 4.2 7.6 0.0 3.0 3 0 0 3 3 3 0 Saccharopine dehydrogenase NADP binding domain Mucin PF01456.17 CCF49063.1 - 0.16 11.9 14.9 0.25 11.4 14.9 1.3 1 0 0 1 1 1 0 Mucin-like glycoprotein Cutinase PF01083.22 CCF49064.1 - 7.6e-30 104.2 1.5 7.6e-30 104.2 1.5 1.7 2 0 0 2 2 2 1 Cutinase YchF-GTPase_C PF06071.13 CCF49066.1 - 1.1e-32 112.0 1.0 5.9e-32 109.7 0.2 2.4 2 1 0 2 2 2 1 Protein of unknown function (DUF933) MMR_HSR1 PF01926.23 CCF49066.1 - 5.5e-17 61.9 0.0 1.9e-16 60.1 0.0 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 CCF49066.1 - 2.2e-05 24.1 0.0 3.9e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 Ferrous iron transport protein B TGS PF02824.21 CCF49066.1 - 0.027 14.5 0.0 0.052 13.6 0.0 1.5 1 0 0 1 1 1 0 TGS domain BetaGal_dom3 PF13363.6 CCF49066.1 - 0.15 11.7 0.5 0.29 10.7 0.0 1.7 2 0 0 2 2 2 0 Beta-galactosidase, domain 3 Pro-kuma_activ PF09286.11 CCF49067.1 - 9.4e-34 116.7 0.0 2e-33 115.7 0.0 1.6 1 0 0 1 1 1 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.22 CCF49067.1 - 8.3e-07 28.5 0.2 1.5e-06 27.7 0.2 1.3 1 0 0 1 1 1 1 Subtilase family Glyco_hydro_115 PF15979.5 CCF49068.1 - 1e-125 419.7 0.1 1.7e-125 419.0 0.1 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 115 GH115_C PF17829.1 CCF49068.1 - 1.1e-29 103.5 0.0 2.2e-29 102.5 0.0 1.5 1 0 0 1 1 1 1 Gylcosyl hydrolase family 115 C-terminal domain TMPIT PF07851.13 CCF49069.1 - 7 5.8 9.2 0.48 9.6 4.1 1.7 2 0 0 2 2 2 0 TMPIT-like protein DUF3915 PF13054.6 CCF49069.1 - 7.8 6.5 12.7 0.056 13.4 3.8 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3915) UCR_UQCRX_QCR9 PF05365.12 CCF49070.1 - 8.4e-28 96.1 4.1 9.2e-28 95.9 4.1 1.0 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like YqzE PF14038.6 CCF49072.1 - 0.038 14.0 2.0 0.19 11.8 1.5 2.1 2 0 0 2 2 2 0 YqzE-like protein DEAD PF00270.29 CCF49073.1 - 7.1e-44 149.7 0.1 1.3e-43 148.8 0.1 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CCF49073.1 - 9.9e-33 112.8 0.2 4.2e-32 110.8 0.0 2.1 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 CCF49073.1 - 0.0011 19.0 0.0 0.0025 17.9 0.0 1.5 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit UTP25 PF06862.12 CCF49073.1 - 0.012 14.4 0.1 0.37 9.5 0.0 2.1 2 0 0 2 2 2 0 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 AAA_19 PF13245.6 CCF49073.1 - 0.013 15.8 0.2 0.077 13.3 0.1 2.1 2 1 0 2 2 2 0 AAA domain AAA_30 PF13604.6 CCF49073.1 - 0.064 13.0 0.0 0.11 12.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain DUF3449 PF11931.8 CCF49074.1 - 1.6e-67 226.9 0.4 4.3e-67 225.5 0.0 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF3449) SF3A3 PF16837.5 CCF49074.1 - 5.2e-24 84.6 0.5 5.2e-24 84.6 0.5 2.1 2 0 0 2 2 2 1 Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 SF3a60_bindingd PF12108.8 CCF49074.1 - 2.8e-10 39.9 0.4 6.1e-10 38.8 0.4 1.6 1 0 0 1 1 1 1 Splicing factor SF3a60 binding domain zf-C2H2_jaz PF12171.8 CCF49074.1 - 1.3e-05 25.4 7.6 5.2e-05 23.4 0.2 2.8 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 CCF49074.1 - 0.00065 20.0 6.0 0.0024 18.2 0.6 2.7 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 CCF49074.1 - 0.0056 17.0 0.8 5.3 7.4 0.1 2.6 2 0 0 2 2 2 2 C2H2 type zinc-finger (2 copies) zf-DBF PF07535.12 CCF49074.1 - 1.4 9.0 4.8 27 5.0 0.0 2.8 2 0 0 2 2 2 0 DBF zinc finger RNase_HII PF01351.18 CCF49075.1 - 1.3e-44 152.4 0.0 1.2e-39 136.3 0.0 2.3 1 1 0 2 2 2 2 Ribonuclease HII DNA_pol_A_exo1 PF01612.20 CCF49076.1 - 8.2e-41 139.6 0.5 1.4e-40 138.9 0.5 1.4 1 0 0 1 1 1 1 3'-5' exonuclease PMC2NT PF08066.12 CCF49076.1 - 1.3e-24 86.7 0.3 3.9e-24 85.2 0.3 1.9 1 0 0 1 1 1 1 PMC2NT (NUC016) domain HRDC PF00570.23 CCF49076.1 - 2.8e-10 40.0 0.1 6.8e-10 38.8 0.1 1.7 1 0 0 1 1 1 1 HRDC domain Glyco_hydro_17 PF00332.18 CCF49077.1 - 2.1e-10 40.7 0.8 4.9e-08 32.9 0.1 2.3 2 1 0 2 2 2 2 Glycosyl hydrolases family 17 Ribosomal_S11 PF00411.19 CCF49078.1 - 2.8e-11 43.8 0.0 6e-11 42.7 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein S11 DUF92 PF01940.16 CCF49079.1 - 9.8e-75 251.0 5.5 1.3e-74 250.6 5.5 1.1 1 0 0 1 1 1 1 Integral membrane protein DUF92 COG6 PF06419.11 CCF49080.1 - 7.9e-153 510.0 0.0 1.2e-152 509.4 0.0 1.2 1 0 0 1 1 1 1 Conserved oligomeric complex COG6 PTR2 PF00854.21 CCF49082.1 - 6.3e-78 262.3 13.6 8.1e-78 262.0 13.6 1.1 1 0 0 1 1 1 1 POT family Cation_efflux PF01545.21 CCF49083.1 - 4.6e-48 163.6 12.3 4.6e-48 163.6 12.3 2.3 2 1 0 2 2 2 1 Cation efflux family GRP PF07172.11 CCF49083.1 - 0.02 15.6 4.0 0.02 15.6 4.0 2.9 3 0 0 3 3 3 0 Glycine rich protein family Zip PF02535.22 CCF49083.1 - 1 8.5 34.1 0.15 11.2 0.5 3.6 4 0 0 4 4 4 0 ZIP Zinc transporter EF-hand_1 PF00036.32 CCF49084.1 - 5.2e-20 69.4 0.1 1.2e-05 24.5 0.0 4.0 5 0 0 5 5 5 3 EF hand EF-hand_6 PF13405.6 CCF49084.1 - 1.8e-17 61.7 0.1 6e-06 25.8 0.1 4.3 4 0 0 4 4 4 3 EF-hand domain EF-hand_7 PF13499.6 CCF49084.1 - 2e-15 57.0 0.2 2.4e-07 31.1 0.0 3.0 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 CCF49084.1 - 5e-15 54.2 0.1 0.00035 19.9 0.0 3.4 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.6 CCF49084.1 - 6.9e-13 48.2 0.2 6.4e-07 29.1 0.0 3.2 3 1 0 3 3 3 2 EF-hand domain pair Extensin_2 PF04554.13 CCF49084.1 - 0.013 15.5 16.0 0.013 15.5 16.0 2.6 1 1 1 2 2 2 0 Extensin-like region Mucin-like PF16058.5 CCF49084.1 - 0.23 11.6 16.5 0.52 10.4 16.5 1.6 1 0 0 1 1 1 0 Mucin-like PEHE PF15275.6 CCF49085.1 - 3.4e-05 24.5 2.9 3.4e-05 24.5 2.9 5.3 4 2 0 4 4 4 1 PEHE domain SAS4 PF15460.6 CCF49085.1 - 0.00029 20.9 0.7 0.00065 19.7 0.7 1.5 1 0 0 1 1 1 1 Something about silencing, SAS, complex subunit 4 Exo_endo_phos PF03372.23 CCF49087.1 - 5e-11 42.6 0.0 7.5e-11 42.0 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Mad3_BUB1_I PF08311.12 CCF49088.1 - 4.2e-41 139.8 0.3 7.3e-41 139.0 0.3 1.4 1 0 0 1 1 1 1 Mad3/BUB1 homology region 1 Pkinase PF00069.25 CCF49088.1 - 3.4e-08 33.2 0.0 7.6e-07 28.8 0.0 2.3 2 0 0 2 2 2 1 Protein kinase domain SRP-alpha_N PF04086.13 CCF49089.1 - 8.8 6.1 9.3 11 5.8 9.3 1.2 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal ELFV_dehydrog PF00208.21 CCF49090.1 - 8.7e-54 182.8 0.0 1.3e-53 182.3 0.0 1.2 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Bac_GDH PF05088.12 CCF49090.1 - 1.8e-21 75.6 0.0 1.1e-14 53.0 0.0 2.2 2 0 0 2 2 2 2 Bacterial NAD-glutamate dehydrogenase PAG PF15347.6 CCF49091.1 - 0.0013 17.8 0.1 0.0014 17.7 0.1 1.2 1 0 0 1 1 1 1 Phosphoprotein associated with glycosphingolipid-enriched Shisa PF13908.6 CCF49091.1 - 0.036 14.3 0.8 0.06 13.6 0.8 1.4 1 1 0 1 1 1 0 Wnt and FGF inhibitory regulator Comm PF15957.5 CCF49091.1 - 0.06 13.7 0.0 0.075 13.4 0.0 1.3 1 0 0 1 1 1 0 Commissureless Hum_adeno_E3A PF05393.11 CCF49091.1 - 0.06 13.3 0.0 0.081 12.9 0.0 1.5 1 0 0 1 1 1 0 Human adenovirus early E3A glycoprotein EphA2_TM PF14575.6 CCF49091.1 - 0.069 14.0 0.0 0.089 13.7 0.0 1.3 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Git3 PF11710.8 CCF49091.1 - 0.071 12.9 0.6 0.094 12.5 0.6 1.1 1 0 0 1 1 1 0 G protein-coupled glucose receptor regulating Gpa2 CD34_antigen PF06365.12 CCF49091.1 - 0.087 12.4 0.0 0.099 12.2 0.0 1.1 1 0 0 1 1 1 0 CD34/Podocalyxin family MAP17 PF15807.5 CCF49091.1 - 0.1 12.9 0.0 0.14 12.4 0.0 1.2 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 HemY_N PF07219.13 CCF49091.1 - 0.42 10.8 2.2 0.76 10.0 1.6 1.7 1 1 0 1 1 1 0 HemY protein N-terminus F-box-like PF12937.7 CCF49092.1 - 0.00033 20.5 0.6 0.00087 19.1 0.6 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 CCF49092.1 - 0.015 15.2 0.4 0.054 13.4 0.1 2.1 2 0 0 2 2 2 0 F-box domain CbiG_C PF01890.16 CCF49092.1 - 0.13 12.9 0.1 1.6 9.4 0.0 2.3 2 0 0 2 2 2 0 Cobalamin synthesis G C-terminus Proteasome PF00227.26 CCF49093.1 - 1e-56 191.5 0.5 1.2e-56 191.2 0.5 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 CCF49093.1 - 1e-13 50.7 0.0 1.9e-13 49.8 0.0 1.5 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Abhydrolase_6 PF12697.7 CCF49094.1 - 3.8e-05 24.4 0.1 9.2e-05 23.1 0.0 1.9 1 1 1 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.7 CCF49094.1 - 0.00086 19.1 0.0 0.0026 17.5 0.0 1.8 1 0 0 1 1 1 1 Alpha/beta hydrolase family Chlorophyllase2 PF12740.7 CCF49094.1 - 0.0019 17.2 0.0 0.0027 16.6 0.0 1.2 1 0 0 1 1 1 1 Chlorophyllase enzyme Lipase_3 PF01764.25 CCF49094.1 - 0.0021 17.9 0.0 0.03 14.2 0.0 2.2 2 0 0 2 2 2 1 Lipase (class 3) Hydrolase_4 PF12146.8 CCF49094.1 - 0.0052 16.1 0.0 0.0091 15.3 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 PGAP1 PF07819.13 CCF49094.1 - 0.0062 16.3 0.0 0.011 15.5 0.0 1.3 1 0 0 1 1 1 1 PGAP1-like protein Hph PF13694.6 CCF49094.1 - 0.14 12.5 0.0 0.28 11.5 0.0 1.5 1 0 0 1 1 1 0 Sec63/Sec62 complex-interacting family DUF2974 PF11187.8 CCF49094.1 - 0.17 11.4 0.0 0.32 10.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) DEAD_assoc PF08494.11 CCF49095.1 - 0.019 14.7 0.2 0.036 13.9 0.2 1.4 1 1 0 1 1 1 0 DEAD/H associated zf-CCHC PF00098.23 CCF49095.1 - 0.77 10.0 4.6 1.3 9.2 4.6 1.4 1 0 0 1 1 1 0 Zinc knuckle Dioxygenase_C PF00775.21 CCF49096.1 - 8.3e-08 31.9 0.2 1.5e-05 24.5 0.2 2.3 1 1 0 1 1 1 1 Dioxygenase Abhydrolase_1 PF00561.20 CCF49097.1 - 4.8e-20 72.3 0.2 1.6e-19 70.6 0.2 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CCF49097.1 - 7e-16 59.5 2.4 7e-16 59.5 2.4 1.6 2 0 0 2 2 2 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CCF49097.1 - 2.6e-10 40.0 0.0 5.3e-10 39.0 0.0 1.5 1 0 0 1 1 1 1 Serine aminopeptidase, S33 CMD PF02627.20 CCF49097.1 - 1e-08 35.1 0.7 3e-08 33.6 0.7 1.9 1 0 0 1 1 1 1 Carboxymuconolactone decarboxylase family Peptidase_S9 PF00326.21 CCF49097.1 - 2e-05 24.2 0.0 0.029 13.8 0.0 2.3 2 0 0 2 2 2 2 Prolyl oligopeptidase family Ndr PF03096.14 CCF49097.1 - 2.5e-05 23.1 0.0 4.9e-05 22.2 0.0 1.5 1 1 0 1 1 1 1 Ndr family Esterase PF00756.20 CCF49097.1 - 0.00017 21.3 0.1 0.00033 20.4 0.1 1.4 1 0 0 1 1 1 1 Putative esterase BAAT_C PF08840.11 CCF49097.1 - 0.011 15.7 0.0 1.3 8.9 0.0 2.2 2 0 0 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal Ribosomal_L22 PF00237.19 CCF49098.1 - 8.7e-34 115.9 0.1 1.2e-33 115.4 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e PAP_central PF04928.17 CCF49099.1 - 9.8e-108 358.8 0.0 1.9e-107 357.9 0.0 1.4 2 0 0 2 2 2 1 Poly(A) polymerase central domain PAP_RNA-bind PF04926.15 CCF49099.1 - 3.9e-57 192.6 0.1 7.9e-57 191.6 0.0 1.6 2 0 0 2 2 2 1 Poly(A) polymerase predicted RNA binding domain NTP_transf_2 PF01909.23 CCF49099.1 - 2.6e-11 43.7 0.0 6.3e-11 42.4 0.0 1.6 1 0 0 1 1 1 1 Nucleotidyltransferase domain Nrap_D2 PF17403.2 CCF49099.1 - 0.024 14.4 0.2 0.043 13.6 0.2 1.4 1 0 0 1 1 1 0 Nrap protein PAP/OAS-like domain Polbeta PF18765.1 CCF49099.1 - 0.15 12.2 0.0 0.37 10.9 0.0 1.6 1 0 0 1 1 1 0 Polymerase beta, Nucleotidyltransferase DNA_methylase PF00145.17 CCF49100.1 - 1.2e-43 149.8 0.0 3e-43 148.4 0.0 1.6 1 1 0 1 1 1 1 C-5 cytosine-specific DNA methylase ENTH PF01417.20 CCF49101.1 - 3.7e-44 149.8 0.1 5.4e-44 149.2 0.1 1.2 1 0 0 1 1 1 1 ENTH domain ANTH PF07651.16 CCF49101.1 - 0.00021 20.4 0.0 0.0003 19.9 0.0 1.2 1 0 0 1 1 1 1 ANTH domain NB-LRR PF12061.8 CCF49101.1 - 0.18 11.1 0.0 0.26 10.6 0.0 1.1 1 0 0 1 1 1 0 Late blight resistance protein R1 Peptidase_M16 PF00675.20 CCF49102.1 - 8.6e-55 184.8 0.2 2.2e-54 183.5 0.2 1.7 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 CCF49102.1 - 2.5e-39 135.2 0.0 6.1e-37 127.4 0.0 2.2 2 0 0 2 2 2 2 Peptidase M16 inactive domain WD40 PF00400.32 CCF49103.1 - 2.3e-05 25.0 0.2 1.1 10.2 0.0 4.0 3 0 0 3 3 3 2 WD domain, G-beta repeat SurE PF01975.17 CCF49104.1 - 8.7e-32 110.5 0.0 8.7e-32 110.5 0.0 2.3 2 1 0 2 2 2 1 Survival protein SurE EF-hand_6 PF13405.6 CCF49107.1 - 3.9e-08 32.6 0.1 0.0014 18.4 0.0 2.8 2 0 0 2 2 2 2 EF-hand domain RRM_1 PF00076.22 CCF49107.1 - 1.5e-07 31.1 0.0 3.4e-07 30.0 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) EF-hand_7 PF13499.6 CCF49107.1 - 2.7e-07 30.9 0.1 1e-06 29.1 0.1 2.0 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 CCF49107.1 - 5.7e-06 25.5 0.1 0.1 12.2 0.1 2.5 2 0 0 2 2 2 2 EF hand RRM_occluded PF16842.5 CCF49107.1 - 0.001 18.8 0.2 0.0026 17.6 0.1 1.7 2 0 0 2 2 2 1 Occluded RNA-recognition motif EF-hand_5 PF13202.6 CCF49107.1 - 0.0038 16.7 0.2 4 7.1 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 CCF49107.1 - 0.0089 15.9 0.1 0.43 10.5 0.1 2.5 2 0 0 2 2 2 1 EF-hand domain pair PepSY_2 PF13670.6 CCF49107.1 - 0.42 10.7 5.5 0.095 12.7 0.4 2.5 2 0 0 2 2 2 0 Peptidase propeptide and YPEB domain RVT_2 PF07727.14 CCF49108.1 - 4.1e-49 167.4 0.2 6.5e-49 166.8 0.2 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) gag_pre-integrs PF13976.6 CCF49108.1 - 0.00047 20.0 1.0 0.0013 18.5 1.0 1.8 1 0 0 1 1 1 1 GAG-pre-integrase domain Retrotran_gag_2 PF14223.6 CCF49109.1 - 9.3e-12 44.8 0.1 1.3e-11 44.4 0.1 1.2 1 0 0 1 1 1 1 gag-polypeptide of LTR copia-type RepC PF06504.11 CCF49109.1 - 0.11 11.6 0.0 0.14 11.3 0.0 1.3 1 1 0 1 1 1 0 Replication protein C (RepC) Casein PF00363.18 CCF49109.1 - 0.2 12.1 0.2 0.2 12.1 0.2 1.6 2 0 0 2 2 2 0 Casein Aconitase PF00330.20 CCF49110.1 - 4.8e-165 550.0 0.1 5.8e-165 549.8 0.1 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 CCF49110.1 - 2.6e-43 147.5 0.0 5.3e-43 146.5 0.0 1.6 1 0 0 1 1 1 1 Aconitase C-terminal domain Ribosomal_L5 PF00281.19 CCF49110.1 - 0.15 12.4 0.0 0.61 10.5 0.0 2.1 1 0 0 1 1 1 0 Ribosomal protein L5 ABC_membrane PF00664.23 CCF49111.1 - 2.9e-107 358.4 28.7 3.3e-60 204.1 17.5 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 CCF49111.1 - 8.7e-67 223.9 0.0 4.1e-32 111.5 0.0 2.7 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 CCF49111.1 - 9.5e-16 57.9 1.4 1.1e-05 25.0 0.0 4.0 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain ABC_ATPase PF09818.9 CCF49111.1 - 7.5e-08 31.6 3.2 0.0074 15.1 0.1 3.1 3 0 0 3 3 3 2 Predicted ATPase of the ABC class AAA_29 PF13555.6 CCF49111.1 - 3.1e-07 30.0 0.2 0.0041 16.8 0.0 2.8 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 CCF49111.1 - 4.8e-07 30.3 5.2 0.0074 16.7 0.4 3.5 2 2 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.6 CCF49111.1 - 7.1e-07 29.6 0.3 0.13 12.6 0.0 3.6 2 2 0 2 2 2 2 AAA domain AAA_15 PF13175.6 CCF49111.1 - 2.2e-06 27.7 0.0 0.029 14.1 0.0 2.3 2 0 0 2 2 2 2 AAA ATPase domain AAA_21 PF13304.6 CCF49111.1 - 3.4e-06 27.1 0.1 0.07 12.9 0.0 3.4 4 0 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system Zeta_toxin PF06414.12 CCF49111.1 - 4.9e-05 22.7 0.0 0.35 10.1 0.0 2.7 2 0 0 2 2 2 2 Zeta toxin RsgA_GTPase PF03193.16 CCF49111.1 - 5.2e-05 23.2 0.0 0.34 10.8 0.0 2.7 2 0 0 2 2 2 2 RsgA GTPase SbcCD_C PF13558.6 CCF49111.1 - 0.0002 21.6 3.7 0.99 9.7 0.1 4.0 2 2 0 2 2 2 2 Putative exonuclease SbcCD, C subunit AAA_25 PF13481.6 CCF49111.1 - 0.00028 20.5 0.0 0.11 12.0 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 CCF49111.1 - 0.0003 21.2 2.3 2.3 8.7 0.1 3.9 2 2 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) G-alpha PF00503.20 CCF49111.1 - 0.00045 19.5 0.0 0.45 9.6 0.0 2.3 2 0 0 2 2 2 2 G-protein alpha subunit AAA_23 PF13476.6 CCF49111.1 - 0.00063 20.3 0.0 1.2 9.5 0.0 2.9 2 0 0 2 2 2 1 AAA domain AAA_7 PF12775.7 CCF49111.1 - 0.00089 18.8 0.0 0.19 11.2 0.0 2.4 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_30 PF13604.6 CCF49111.1 - 0.00089 19.0 6.7 0.5 10.1 0.2 4.1 3 2 0 3 3 3 2 AAA domain AAA_14 PF13173.6 CCF49111.1 - 0.0011 19.0 0.0 0.53 10.3 0.0 3.0 3 0 0 3 3 2 1 AAA domain AAA_5 PF07728.14 CCF49111.1 - 0.0016 18.4 0.0 2.6 8.0 0.0 3.5 4 0 0 4 4 4 1 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 CCF49111.1 - 0.0038 17.8 0.0 3.6 8.1 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.6 CCF49111.1 - 0.007 16.1 0.0 1.3 8.7 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_28 PF13521.6 CCF49111.1 - 0.011 16.0 0.3 2.2 8.5 0.1 2.7 2 0 0 2 2 2 0 AAA domain DUF815 PF05673.13 CCF49111.1 - 0.014 14.6 0.0 2.1 7.5 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF815) Rad17 PF03215.15 CCF49111.1 - 0.015 15.2 0.0 0.73 9.7 0.0 2.7 2 1 0 2 2 2 0 Rad17 P-loop domain NB-ARC PF00931.22 CCF49111.1 - 0.019 14.2 0.0 2.6 7.2 0.0 2.4 2 0 0 2 2 2 0 NB-ARC domain PRK PF00485.18 CCF49111.1 - 0.028 14.2 0.0 3.4 7.4 0.0 2.6 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family APS_kinase PF01583.20 CCF49111.1 - 0.04 13.8 0.4 1.4 8.7 0.0 3.0 3 0 0 3 3 3 0 Adenylylsulphate kinase DUF87 PF01935.17 CCF49111.1 - 0.044 13.9 3.9 4.1 7.4 0.0 3.2 4 0 0 4 4 3 0 Helicase HerA, central domain AAA_17 PF13207.6 CCF49111.1 - 0.062 13.7 0.0 34 4.8 0.0 3.6 3 0 0 3 3 2 0 AAA domain RNA_helicase PF00910.22 CCF49111.1 - 0.074 13.4 1.4 6.3 7.2 0.0 3.6 4 0 0 4 4 3 0 RNA helicase AAA_33 PF13671.6 CCF49111.1 - 0.12 12.5 5.3 4.7 7.4 0.0 3.8 5 0 0 5 5 2 0 AAA domain Viral_helicase1 PF01443.18 CCF49111.1 - 0.13 11.9 0.0 3.2 7.4 0.0 2.7 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase ATPase PF06745.13 CCF49111.1 - 0.16 11.3 1.0 18 4.6 0.0 3.0 3 0 0 3 3 3 0 KaiC Mog1 PF04603.12 CCF49111.1 - 0.17 12.3 1.5 0.26 11.6 0.1 2.1 2 0 0 2 2 1 0 Ran-interacting Mog1 protein MMR_HSR1 PF01926.23 CCF49111.1 - 0.37 10.9 4.1 15 5.7 0.0 3.9 3 1 1 4 4 3 0 50S ribosome-binding GTPase XRN_M PF17846.1 CCF49111.1 - 0.58 9.1 1.8 1.2 8.0 1.8 1.4 1 0 0 1 1 1 0 Xrn1 helical domain CDC45 PF02724.14 CCF49111.1 - 4.2 5.5 8.6 1.6 6.9 2.3 2.2 2 0 0 2 2 2 0 CDC45-like protein Dynamin_N PF00350.23 CCF49112.1 - 1.8e-17 63.9 3.5 4.2e-16 59.4 0.0 3.1 3 0 0 3 3 3 1 Dynamin family MMR_HSR1 PF01926.23 CCF49112.1 - 2.3e-11 43.8 0.3 3.8e-10 39.9 0.0 2.9 2 1 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 CCF49112.1 - 2.5e-07 30.4 0.0 9.8e-05 22.0 0.0 2.7 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 CCF49112.1 - 9.6e-06 25.6 0.4 0.14 12.0 0.2 2.8 2 1 1 3 3 3 2 RsgA GTPase cobW PF02492.19 CCF49112.1 - 0.00091 18.9 0.3 0.0058 16.2 0.3 2.2 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain IIGP PF05049.13 CCF49112.1 - 0.0056 15.8 0.1 0.02 14.0 0.0 1.9 2 0 0 2 2 2 1 Interferon-inducible GTPase (IIGP) TsaE PF02367.17 CCF49112.1 - 0.0077 16.2 0.0 0.025 14.6 0.0 1.8 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_16 PF13191.6 CCF49112.1 - 0.019 15.4 0.8 0.099 13.0 0.1 2.7 1 1 1 2 2 2 0 AAA ATPase domain AAA_29 PF13555.6 CCF49112.1 - 0.019 14.7 0.0 0.088 12.6 0.0 2.1 2 0 0 2 2 2 0 P-loop containing region of AAA domain T2SSE PF00437.20 CCF49112.1 - 0.021 13.9 0.0 0.11 11.6 0.0 2.2 2 0 0 2 2 2 0 Type II/IV secretion system protein Roc PF08477.13 CCF49112.1 - 0.052 13.8 0.0 5.6 7.2 0.0 3.1 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase ABM PF03992.16 CCF49113.1 - 7.6e-07 29.2 0.0 9.4e-07 28.9 0.0 1.2 1 0 0 1 1 1 1 Antibiotic biosynthesis monooxygenase P22_AR_C PF10548.9 CCF49113.1 - 0.11 12.6 0.0 7.5 6.8 0.0 2.1 2 0 0 2 2 2 0 P22AR C-terminal domain DUF406 PF04175.12 CCF49113.1 - 0.29 11.6 1.5 4 8.0 0.2 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF406) PQ-loop PF04193.14 CCF49114.1 - 7.4e-26 89.7 6.6 2.5e-13 49.6 3.5 3.0 4 0 0 4 4 4 2 PQ loop repeat Comm PF15957.5 CCF49114.1 - 0.012 16.0 0.2 0.031 14.6 0.0 1.8 2 0 0 2 2 2 0 Commissureless SARAF PF06682.12 CCF49115.1 - 1.8e-62 211.9 0.1 2.3e-62 211.6 0.1 1.1 1 0 0 1 1 1 1 SOCE-associated regulatory factor of calcium homoeostasis CPSase_L_D2 PF02786.17 CCF49116.1 - 8.6e-53 179.0 0.0 1.9e-52 177.8 0.0 1.6 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Carboxyl_trans PF01039.22 CCF49116.1 - 1e-42 146.4 0.1 2.1e-42 145.4 0.1 1.5 1 0 0 1 1 1 1 Carboxyl transferase domain Biotin_carb_N PF00289.22 CCF49116.1 - 1.2e-29 103.1 0.0 4.1e-29 101.3 0.0 2.0 2 0 0 2 2 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 CCF49116.1 - 2.4e-21 75.8 0.0 4.9e-21 74.9 0.0 1.6 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.22 CCF49116.1 - 1.4e-11 44.1 4.2 3.8e-11 42.7 4.2 1.8 1 0 0 1 1 1 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.6 CCF49116.1 - 5.8e-07 29.2 5.8 0.0029 17.4 0.5 2.7 1 1 1 2 2 2 2 Biotin-lipoyl like Dala_Dala_lig_C PF07478.13 CCF49116.1 - 0.00054 19.5 0.0 0.021 14.4 0.0 2.5 2 0 0 2 2 2 1 D-ala D-ala ligase C-terminus ATPgrasp_ST PF14397.6 CCF49116.1 - 0.0044 16.3 0.0 0.012 14.9 0.0 1.6 1 0 0 1 1 1 1 Sugar-transfer associated ATP-grasp ATP-grasp_3 PF02655.14 CCF49116.1 - 0.011 15.7 0.1 0.17 12.0 0.0 2.7 2 1 0 2 2 2 0 ATP-grasp domain ECH_1 PF00378.20 CCF49116.1 - 0.014 14.7 0.6 0.034 13.4 0.6 1.6 1 0 0 1 1 1 0 Enoyl-CoA hydratase/isomerase HlyD_D23 PF16576.5 CCF49116.1 - 0.029 13.6 4.7 0.13 11.5 1.2 2.4 1 1 1 2 2 2 0 Barrel-sandwich domain of CusB or HlyD membrane-fusion ATPgrasp_Ter PF15632.6 CCF49116.1 - 0.055 13.2 0.1 0.22 11.3 0.0 2.0 2 0 0 2 2 2 0 ATP-grasp in the biosynthetic pathway with Ter operon HlyD_3 PF13437.6 CCF49116.1 - 0.13 13.0 1.8 3.7 8.3 0.1 2.5 1 1 1 2 2 2 0 HlyD family secretion protein DUF2118 PF09891.9 CCF49116.1 - 0.19 11.7 2.6 0.45 10.5 0.4 2.6 3 0 0 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2118) FHA PF00498.26 CCF49117.1 - 2.6e-08 34.1 0.0 4.9e-08 33.2 0.0 1.5 1 0 0 1 1 1 1 FHA domain HIT PF01230.23 CCF49118.1 - 3.6e-24 85.3 0.3 4.7e-24 85.0 0.3 1.1 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.8 CCF49118.1 - 6e-14 52.5 0.1 7.9e-14 52.1 0.1 1.1 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding CwfJ_C_1 PF04677.15 CCF49118.1 - 1.9e-05 24.5 0.0 2.9e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 Rotamase PF00639.21 CCF49119.1 - 1.3e-22 80.6 0.1 1.7e-22 80.2 0.1 1.2 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_3 PF13616.6 CCF49119.1 - 2.6e-21 76.3 0.1 3.5e-21 75.9 0.1 1.2 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_2 PF13145.6 CCF49119.1 - 4.5e-07 30.7 0.1 6.6e-07 30.2 0.1 1.3 1 0 0 1 1 1 1 PPIC-type PPIASE domain WW PF00397.26 CCF49119.1 - 1.7e-06 28.0 2.2 4.2e-06 26.8 1.0 2.1 2 0 0 2 2 2 1 WW domain YABBY PF04690.13 CCF49121.1 - 1.6e-10 41.8 0.6 1.7e-10 41.7 0.6 1.0 1 0 0 1 1 1 1 YABBY protein Ccdc124 PF06244.12 CCF49121.1 - 3.8e-06 27.5 1.9 3.9e-06 27.4 1.9 1.0 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 124 /Oxs1 HMG_box_2 PF09011.10 CCF49121.1 - 3.6e-05 24.3 2.0 4.5e-05 23.9 2.0 1.1 1 0 0 1 1 1 1 HMG-box domain HMG_box PF00505.19 CCF49121.1 - 0.00019 21.8 2.6 0.00023 21.5 2.6 1.1 1 0 0 1 1 1 1 HMG (high mobility group) box Pkinase PF00069.25 CCF49122.1 - 7.6e-19 68.1 0.6 9e-12 44.9 0.0 5.8 4 2 0 4 4 4 3 Protein kinase domain Pkinase_Tyr PF07714.17 CCF49122.1 - 2e-07 30.5 0.0 0.00023 20.5 0.0 3.5 3 1 0 3 3 3 1 Protein tyrosine kinase RVT_2 PF07727.14 CCF49123.1 - 3.2e-19 69.6 0.1 2.4e-11 43.7 0.0 2.4 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) gag_pre-integrs PF13976.6 CCF49123.1 - 0.004 17.0 0.7 0.017 15.0 0.7 2.1 1 0 0 1 1 1 1 GAG-pre-integrase domain WD40 PF00400.32 CCF49125.1 - 0.0036 18.1 0.4 0.042 14.7 0.0 3.0 4 0 0 4 4 4 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF49125.1 - 0.061 13.6 0.0 0.35 11.2 0.0 2.5 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain Ribosomal_L23eN PF03939.13 CCF49126.1 - 3.7e-21 75.1 7.8 6.6e-21 74.3 7.8 1.4 1 0 0 1 1 1 1 Ribosomal protein L23, N-terminal domain Ribosomal_L23 PF00276.20 CCF49126.1 - 7.7e-15 55.0 2.5 5.6e-14 52.3 0.3 2.5 2 1 0 2 2 2 1 Ribosomal protein L23 AA_permease PF00324.21 CCF49127.1 - 3.4e-122 408.5 44.0 4.2e-122 408.2 44.0 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 CCF49127.1 - 1.6e-33 116.2 44.8 2.2e-33 115.7 44.8 1.1 1 0 0 1 1 1 1 Amino acid permease Synaptobrevin PF00957.21 CCF49127.1 - 0.2 11.5 2.4 12 5.8 0.0 3.2 3 0 0 3 3 3 0 Synaptobrevin RhoGEF PF00621.20 CCF49128.1 - 2.7e-38 132.0 3.2 2.7e-38 132.0 1.8 1.8 2 0 0 2 2 2 1 RhoGEF domain SH3_1 PF00018.28 CCF49128.1 - 1.2e-20 72.9 0.8 2.6e-09 36.5 0.1 2.5 2 0 0 2 2 2 2 SH3 domain EF-hand_4 PF12763.7 CCF49128.1 - 4.4e-16 58.7 0.0 1.3e-15 57.2 0.0 1.8 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand SH3_9 PF14604.6 CCF49128.1 - 5.8e-15 54.9 1.7 5.3e-09 35.8 0.1 2.6 2 0 0 2 2 2 2 Variant SH3 domain SH3_2 PF07653.17 CCF49128.1 - 4.1e-11 42.4 0.0 7.3e-06 25.6 0.0 2.5 2 0 0 2 2 2 2 Variant SH3 domain WH2 PF02205.20 CCF49128.1 - 1.3e-08 34.4 0.4 3.8e-08 32.9 0.4 1.9 1 0 0 1 1 1 1 WH2 motif EF-hand_1 PF00036.32 CCF49128.1 - 0.0026 17.2 0.0 0.42 10.3 0.0 2.6 2 0 0 2 2 2 1 EF hand DUF1720 PF08226.11 CCF49128.1 - 0.0078 16.6 47.6 0.0078 16.6 47.6 6.3 2 2 3 5 5 3 3 Domain of unknown function (DUF1720) PH PF00169.29 CCF49128.1 - 0.027 15.0 0.0 0.08 13.5 0.0 1.7 1 0 0 1 1 1 0 PH domain EF-hand_6 PF13405.6 CCF49128.1 - 0.04 13.9 0.0 19 5.5 0.0 2.6 2 0 0 2 2 2 0 EF-hand domain PH_13 PF16652.5 CCF49128.1 - 1.7 8.5 9.3 0.44 10.3 0.2 3.4 3 1 0 3 3 3 0 Pleckstrin homology domain UIM PF02809.20 CCF49128.1 - 2 8.5 10.8 13 6.0 4.0 3.5 2 0 0 2 2 2 0 Ubiquitin interaction motif NCE101 PF11654.8 CCF49129.1 - 1.1e-18 66.6 0.1 1.9e-18 65.9 0.1 1.3 1 0 0 1 1 1 1 Non-classical export protein 1 DUF2934 PF11154.8 CCF49129.1 - 0.022 14.4 0.2 0.061 13.0 0.2 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF2934) zf-RING_2 PF13639.6 CCF49130.1 - 2e-10 40.8 10.2 3.2e-10 40.2 10.2 1.3 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 CCF49130.1 - 1.7e-08 34.6 8.4 3.4e-08 33.6 8.4 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 CCF49130.1 - 2.2e-06 27.4 9.0 3.6e-06 26.7 9.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 CCF49130.1 - 5.6e-06 26.0 4.4 1.1e-05 25.0 4.4 1.4 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_5 PF14634.6 CCF49130.1 - 8.5e-06 25.6 6.9 1.4e-05 25.0 6.9 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 CCF49130.1 - 1.1e-05 25.1 10.0 1.9e-05 24.4 10.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 CCF49130.1 - 1.1e-05 25.3 3.5 5.3e-05 23.2 4.3 1.7 2 0 0 2 2 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.6 CCF49130.1 - 0.00079 19.2 6.2 0.0014 18.4 6.2 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 CCF49130.1 - 0.0011 18.8 7.4 0.0018 18.1 7.4 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-HC5HC2H PF13771.6 CCF49130.1 - 0.19 12.0 4.9 0.49 10.7 5.0 1.7 1 1 0 1 1 1 0 PHD-like zinc-binding domain zf-C3H2C3 PF17122.5 CCF49130.1 - 0.57 10.3 1.8 1.1 9.4 1.8 1.4 1 0 0 1 1 1 0 Zinc-finger zf-RING_4 PF14570.6 CCF49130.1 - 0.67 9.8 9.3 1.2 8.9 9.3 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING-like PF08746.11 CCF49130.1 - 0.71 10.2 8.5 1.2 9.5 8.5 1.4 1 0 0 1 1 1 0 RING-like domain zf-RING_UBOX PF13445.6 CCF49130.1 - 0.94 9.6 6.6 1.9 8.6 6.6 1.5 1 0 0 1 1 1 0 RING-type zinc-finger Zn_ribbon_17 PF17120.5 CCF49130.1 - 2.1 8.0 7.0 4.3 7.0 7.0 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type PHD PF00628.29 CCF49130.1 - 6.1 6.8 10.2 10 6.1 10.2 1.4 1 0 0 1 1 1 0 PHD-finger RINGv PF12906.7 CCF49130.1 - 6.7 6.9 11.3 12 6.1 11.3 1.4 1 0 0 1 1 1 0 RING-variant domain PTPlike_phytase PF14566.6 CCF49131.1 - 8.3e-141 464.5 0.2 4e-50 170.0 0.1 3.4 3 0 0 3 3 3 3 Inositol hexakisphosphate DSPc PF00782.20 CCF49131.1 - 1.6e-08 34.4 0.0 0.35 10.7 0.0 4.6 5 0 0 5 5 5 3 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 CCF49131.1 - 1.7e-05 24.9 0.0 0.17 11.8 0.0 3.4 3 0 0 3 3 3 2 Tyrosine phosphatase family Y_phosphatase PF00102.27 CCF49131.1 - 4.1e-05 23.3 0.1 0.11 12.0 0.0 3.3 3 0 0 3 3 3 2 Protein-tyrosine phosphatase HisG PF01634.18 CCF49132.1 - 3.1e-51 173.5 0.0 4.5e-51 173.0 0.0 1.3 1 0 0 1 1 1 1 ATP phosphoribosyltransferase HisG_C PF08029.11 CCF49132.1 - 5e-25 87.4 0.1 9.2e-25 86.6 0.1 1.5 1 0 0 1 1 1 1 HisG, C-terminal domain NMT1 PF09084.11 CCF49132.1 - 0.0029 17.6 0.2 0.028 14.4 0.2 2.2 1 1 0 1 1 1 1 NMT1/THI5 like SBP_bac_3 PF00497.20 CCF49132.1 - 0.06 12.8 0.0 0.1 12.0 0.0 1.4 1 0 0 1 1 1 0 Bacterial extracellular solute-binding proteins, family 3 Cation_efflux PF01545.21 CCF49133.1 - 5.7e-07 29.5 0.6 1.1e-06 28.5 0.6 1.5 1 1 0 1 1 1 1 Cation efflux family Pkinase PF00069.25 CCF49134.1 - 5.2e-70 235.8 0.0 6.8e-70 235.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF49134.1 - 3.9e-36 124.7 0.0 5.5e-36 124.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCF49134.1 - 2.1e-09 37.1 0.0 2.9e-09 36.6 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 CCF49134.1 - 7.1e-06 25.0 0.1 7.1e-06 25.0 0.1 2.0 2 0 0 2 2 2 1 Fungal protein kinase Kdo PF06293.14 CCF49134.1 - 2e-05 24.0 0.1 3.9e-05 23.1 0.1 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.9 CCF49134.1 - 0.00085 18.9 0.0 0.0018 17.9 0.0 1.4 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL APH PF01636.23 CCF49134.1 - 0.0048 16.9 0.0 0.0098 15.8 0.0 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family TetR_C_27 PF17935.1 CCF49134.1 - 0.03 14.4 0.0 0.1 12.7 0.0 1.8 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain PGA2 PF07543.12 CCF49134.1 - 0.26 11.3 7.1 0.95 9.4 7.5 1.8 2 0 0 2 2 2 0 Protein trafficking PGA2 EssA PF10661.9 CCF49134.1 - 0.56 10.1 7.4 0.99 9.2 7.4 1.4 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein EssA NOA36 PF06524.12 CCF49134.1 - 3 7.1 6.5 4.4 6.5 6.5 1.3 1 0 0 1 1 1 0 NOA36 protein Oxysterol_BP PF01237.18 CCF49134.1 - 4.7 5.9 8.5 6.4 5.5 8.5 1.2 1 0 0 1 1 1 0 Oxysterol-binding protein DAGK_cat PF00781.24 CCF49135.1 - 3e-23 81.8 0.0 5.9e-23 80.9 0.0 1.5 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain RibD_C PF01872.17 CCF49137.1 - 1.4e-32 113.2 0.0 1.7e-32 112.9 0.0 1.1 1 0 0 1 1 1 1 RibD C-terminal domain HMG_box PF00505.19 CCF49140.1 - 4.1e-11 43.1 5.3 6.4e-10 39.3 5.3 2.4 1 1 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 CCF49140.1 - 7.7e-05 23.2 2.5 0.00019 22.0 2.5 1.7 1 0 0 1 1 1 1 HMG-box domain ubiquitin PF00240.23 CCF49141.1 - 7.7e-26 89.7 0.4 8.5e-26 89.5 0.4 1.0 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 CCF49141.1 - 2e-15 56.4 0.4 2.2e-15 56.2 0.4 1.0 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 CCF49141.1 - 0.00017 22.0 0.1 0.00049 20.5 0.1 1.7 1 1 0 1 1 1 1 Ubiquitin-like domain TBK1_ULD PF18396.1 CCF49141.1 - 0.00057 19.8 0.0 0.00068 19.5 0.0 1.1 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_5 PF18037.1 CCF49141.1 - 0.033 14.5 0.2 0.041 14.3 0.2 1.1 1 0 0 1 1 1 0 Ubiquitin-like domain Ubiquitin_4 PF18036.1 CCF49141.1 - 0.11 12.6 0.6 3.5 7.7 0.6 2.0 1 1 1 2 2 2 0 Ubiquitin-like domain tRNA-synt_His PF13393.6 CCF49142.1 - 8.6e-41 140.2 1.4 3e-34 118.7 0.0 3.1 3 0 0 3 3 3 2 Histidyl-tRNA synthetase HGTP_anticodon PF03129.20 CCF49142.1 - 6.2e-08 32.7 0.0 1.7e-07 31.3 0.0 1.8 1 0 0 1 1 1 1 Anticodon binding domain HGTP_anticodon2 PF12745.7 CCF49142.1 - 8.6e-07 28.7 0.5 6.1e-06 25.9 0.0 2.1 2 0 0 2 2 2 1 Anticodon binding domain of tRNAs APG6_N PF17675.1 CCF49142.1 - 0.0055 17.2 3.2 0.013 16.1 3.2 1.5 1 0 0 1 1 1 1 Apg6 coiled-coil region WHEP-TRS PF00458.20 CCF49142.1 - 0.024 14.8 4.0 0.14 12.3 4.0 2.5 1 0 0 1 1 1 0 WHEP-TRS domain tRNA-synt_2 PF00152.20 CCF49142.1 - 0.096 11.8 0.6 2 7.4 0.2 2.7 2 1 0 2 2 2 0 tRNA synthetases class II (D, K and N) Use1 PF09753.9 CCF49143.1 - 1.3e-12 48.0 3.2 3e-12 46.8 0.7 2.3 1 1 1 2 2 2 1 Membrane fusion protein Use1 FlxA PF14282.6 CCF49143.1 - 0.011 15.8 1.4 0.011 15.8 1.4 2.3 3 0 0 3 3 3 0 FlxA-like protein SNARE PF05739.19 CCF49143.1 - 0.059 13.4 0.2 0.23 11.5 0.1 2.2 2 0 0 2 2 2 0 SNARE domain Syntaxin-6_N PF09177.11 CCF49143.1 - 7.1 7.3 7.3 4 8.0 2.9 2.8 2 1 0 2 2 2 0 Syntaxin 6, N-terminal zf-HC5HC2H_2 PF13832.6 CCF49144.1 - 1.1e-31 109.2 6.9 1.1e-31 109.2 6.9 2.3 2 0 0 2 2 2 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 CCF49144.1 - 1.4e-23 83.0 4.2 1.4e-23 83.0 4.2 2.9 3 0 0 3 3 3 2 PHD-like zinc-binding domain EPL1 PF10513.9 CCF49144.1 - 5.4e-23 82.1 0.2 5.4e-23 82.1 0.2 4.1 3 2 0 4 4 4 1 Enhancer of polycomb-like Bromodomain PF00439.25 CCF49144.1 - 1.3e-20 73.2 0.4 2.7e-20 72.2 0.4 1.5 1 0 0 1 1 1 1 Bromodomain PHD_2 PF13831.6 CCF49144.1 - 1.2e-14 53.6 2.6 1.2e-14 53.6 2.6 2.6 2 0 0 2 2 2 1 PHD-finger PWWP PF00855.17 CCF49144.1 - 1.2e-09 38.5 0.1 4.3e-09 36.7 0.1 2.1 1 0 0 1 1 1 1 PWWP domain PHD PF00628.29 CCF49144.1 - 1.3e-09 37.8 9.2 1.3e-09 37.8 9.2 2.7 2 0 0 2 2 2 1 PHD-finger Syntaxin-18_N PF10496.9 CCF49144.1 - 0.086 13.1 0.7 0.8 10.0 0.7 2.7 1 0 0 1 1 1 0 SNARE-complex protein Syntaxin-18 N-terminus C1_1 PF00130.22 CCF49144.1 - 2.5 8.1 15.1 0.056 13.3 2.1 2.6 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Coiled-coil_56 PF09813.9 CCF49145.1 - 1.2e-05 25.3 0.0 1.8e-05 24.7 0.0 1.3 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 56 Scramblase PF03803.15 CCF49146.1 - 1.1e-59 201.5 0.0 1.4e-59 201.1 0.0 1.1 1 0 0 1 1 1 1 Scramblase Romo1 PF10247.9 CCF49147.1 - 2.1e-24 85.7 10.8 2.7e-24 85.3 10.8 1.1 1 0 0 1 1 1 1 Reactive mitochondrial oxygen species modulator 1 Na_H_antiport_1 PF06965.12 CCF49147.1 - 0.78 8.5 3.6 0.95 8.2 3.6 1.1 1 0 0 1 1 1 0 Na+/H+ antiporter 1 Macro PF01661.21 CCF49148.1 - 3.9e-41 139.8 0.0 7.7e-41 138.8 0.0 1.5 2 0 0 2 2 2 1 Macro domain Peptidase_M24 PF00557.24 CCF49149.1 - 1.2e-39 136.2 0.2 1.6e-39 135.8 0.2 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 YL1 PF05764.13 CCF49149.1 - 0.00093 19.4 11.4 0.0014 18.8 11.4 1.2 1 0 0 1 1 1 1 YL1 nuclear protein TFIIF_alpha PF05793.12 CCF49149.1 - 0.0042 15.7 11.6 0.006 15.2 11.6 1.2 1 0 0 1 1 1 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) SDA1 PF05285.12 CCF49149.1 - 0.02 14.3 11.8 0.028 13.8 11.8 1.1 1 0 0 1 1 1 0 SDA1 RNA_pol_Rpc4 PF05132.14 CCF49149.1 - 0.16 12.4 7.4 0.28 11.6 7.4 1.3 1 0 0 1 1 1 0 RNA polymerase III RPC4 CDC45 PF02724.14 CCF49149.1 - 0.2 9.9 11.5 0.29 9.4 11.5 1.2 1 0 0 1 1 1 0 CDC45-like protein CCDC106 PF15794.5 CCF49149.1 - 0.3 10.7 7.3 0.63 9.7 7.3 1.4 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 Spt20 PF12090.8 CCF49149.1 - 0.38 10.3 6.1 0.64 9.6 6.1 1.4 1 0 0 1 1 1 0 Spt20 family CENP-B_dimeris PF09026.10 CCF49149.1 - 0.42 11.0 9.2 0.89 10.0 9.2 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain RNA_polI_A34 PF08208.11 CCF49149.1 - 0.45 10.6 11.2 0.77 9.8 11.2 1.4 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 Apt1 PF10351.9 CCF49149.1 - 0.48 9.2 4.3 0.62 8.8 4.3 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain TRAP_alpha PF03896.16 CCF49149.1 - 0.78 8.9 3.8 1.2 8.3 3.8 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit DNA_pol_phi PF04931.13 CCF49149.1 - 1.6 6.7 7.2 2.6 6.0 7.2 1.2 1 0 0 1 1 1 0 DNA polymerase phi Peptidase_S64 PF08192.11 CCF49149.1 - 1.6 7.1 6.6 2.2 6.6 6.6 1.1 1 0 0 1 1 1 0 Peptidase family S64 DUF3381 PF11861.8 CCF49149.1 - 2.2 8.1 13.7 0.094 12.5 7.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3381) NST1 PF13945.6 CCF49149.1 - 3.8 7.6 11.4 6.3 6.9 11.4 1.3 1 0 0 1 1 1 0 Salt tolerance down-regulator PGA2 PF07543.12 CCF49149.1 - 3.8 7.5 15.0 0.12 12.3 8.2 1.9 2 0 0 2 2 2 0 Protein trafficking PGA2 GATase_6 PF13522.6 CCF49150.1 - 3.3e-14 53.2 0.0 9.8e-14 51.7 0.0 1.8 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.6 CCF49150.1 - 2.4e-10 40.4 0.0 5.4e-10 39.2 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase domain Pribosyltran PF00156.27 CCF49150.1 - 4e-10 39.4 0.1 8.7e-10 38.3 0.1 1.7 1 0 0 1 1 1 1 Phosphoribosyl transferase domain GATase_4 PF13230.6 CCF49150.1 - 5.1e-06 25.6 0.0 1e-05 24.6 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferases class-II Activator_LAG-3 PF11498.8 CCF49150.1 - 0.085 11.8 2.0 0.13 11.2 2.0 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 cwf18 PF08315.12 CCF49151.1 - 5.9e-30 104.7 5.6 8.6e-30 104.2 5.6 1.2 1 0 0 1 1 1 1 cwf18 pre-mRNA splicing factor RbpA PF13397.6 CCF49151.1 - 0.021 15.4 2.6 0.058 14.0 0.5 2.2 1 1 1 2 2 2 0 RNA polymerase-binding protein YL1 PF05764.13 CCF49152.1 - 1.4e-51 176.0 25.6 1.4e-51 176.0 25.6 3.0 3 0 0 3 3 3 1 YL1 nuclear protein YL1_C PF08265.11 CCF49152.1 - 3.4e-15 55.5 1.0 5.9e-15 54.7 1.0 1.4 1 0 0 1 1 1 1 YL1 nuclear protein C-terminal domain Methyltransf_25 PF13649.6 CCF49153.1 - 0.0015 19.2 0.0 0.43 11.3 0.0 3.2 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF49153.1 - 0.012 16.3 0.1 3.7 8.3 0.0 3.1 2 1 1 3 3 3 0 Methyltransferase domain Methyltransf_12 PF08242.12 CCF49153.1 - 0.046 14.5 0.1 10 6.9 0.1 2.6 1 1 1 2 2 2 0 Methyltransferase domain zf-C2H2 PF00096.26 CCF49154.1 - 1.3 9.6 4.0 2.6 8.7 4.0 1.5 1 0 0 1 1 1 0 Zinc finger, C2H2 type DUF3808 PF10300.9 CCF49155.1 - 1.2e-70 238.6 1.1 2e-70 237.9 1.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3808) CRAL_TRIO PF00650.20 CCF49155.1 - 2e-33 115.4 0.1 5e-33 114.1 0.1 1.7 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.6 CCF49155.1 - 5.5e-12 46.0 0.0 1.3e-11 44.8 0.0 1.7 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain CRAL_TRIO_N PF03765.15 CCF49155.1 - 1.6e-10 41.0 0.2 5.6e-10 39.3 0.2 2.0 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain TPR_12 PF13424.6 CCF49155.1 - 0.00017 21.8 3.2 1.8 8.9 0.0 4.1 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 CCF49155.1 - 0.0061 16.6 12.3 0.97 9.7 1.0 5.2 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.6 CCF49155.1 - 0.17 12.2 7.6 0.57 10.5 0.4 3.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 CCF49155.1 - 0.22 12.2 5.0 0.66 10.7 0.4 3.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.6 CCF49155.1 - 2.3 8.4 6.4 2.9 8.1 0.2 3.9 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 CCF49155.1 - 3.8 8.6 5.2 12 7.0 0.2 3.8 4 0 0 4 4 3 0 Tetratricopeptide repeat Nop14 PF04147.12 CCF49155.1 - 7.6 4.6 22.8 15 3.6 22.8 1.5 1 0 0 1 1 1 0 Nop14-like family 2OG-FeII_Oxy PF03171.20 CCF49156.1 - 2.9e-12 47.0 0.0 1e-11 45.2 0.0 1.9 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.6 CCF49156.1 - 2.7e-11 44.3 0.0 7.4e-11 42.8 0.0 1.7 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal Amidase PF01425.21 CCF49157.1 - 1.2e-39 136.5 0.0 1.9e-39 135.9 0.0 1.4 1 1 0 1 1 1 1 Amidase Abhydrolase_1 PF00561.20 CCF49158.1 - 1.5e-15 57.5 0.2 1.9e-10 40.8 0.1 2.6 2 1 1 3 3 3 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CCF49158.1 - 1.7e-14 53.7 0.0 7.6e-09 35.2 0.0 2.2 1 1 0 2 2 2 2 Serine aminopeptidase, S33 AXE1 PF05448.12 CCF49158.1 - 0.00011 21.0 0.2 0.046 12.4 0.1 2.6 2 2 0 2 2 2 2 Acetyl xylan esterase (AXE1) Abhydrolase_6 PF12697.7 CCF49158.1 - 0.00032 21.4 0.0 0.00044 20.9 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S15 PF02129.18 CCF49158.1 - 0.001 18.7 0.3 0.013 15.1 0.0 2.6 3 1 0 3 3 3 1 X-Pro dipeptidyl-peptidase (S15 family) DLH PF01738.18 CCF49158.1 - 0.005 16.4 0.0 0.7 9.4 0.0 2.5 2 1 0 2 2 2 1 Dienelactone hydrolase family FSH1 PF03959.13 CCF49158.1 - 0.0052 16.5 0.0 0.013 15.1 0.0 1.8 1 1 0 1 1 1 1 Serine hydrolase (FSH1) BAAT_C PF08840.11 CCF49158.1 - 0.0096 15.9 0.1 0.24 11.3 0.0 2.8 3 0 0 3 3 3 1 BAAT / Acyl-CoA thioester hydrolase C terminal Esterase PF00756.20 CCF49158.1 - 0.016 14.8 0.4 0.062 12.9 0.3 2.0 1 1 0 1 1 1 0 Putative esterase Med8 PF10232.9 CCF49158.1 - 0.15 11.6 3.0 0.29 10.7 3.0 1.4 1 0 0 1 1 1 0 Mediator of RNA polymerase II transcription complex subunit 8 Peptidase_M76 PF09768.9 CCF49159.1 - 1.6e-63 213.6 0.0 2e-63 213.2 0.0 1.1 1 0 0 1 1 1 1 Peptidase M76 family Rcd1 PF04078.13 CCF49160.1 - 2e-123 410.7 1.0 2.6e-123 410.4 1.0 1.0 1 0 0 1 1 1 1 Cell differentiation family, Rcd1-like Cyto_heme_lyase PF01265.17 CCF49161.1 - 3.6e-35 122.0 16.1 8.6e-32 110.9 16.0 3.5 1 1 1 2 2 2 2 Cytochrome c/c1 heme lyase PMM PF03332.13 CCF49162.1 - 1.5e-99 332.2 2.1 4.1e-99 330.8 2.1 1.6 1 1 0 1 1 1 1 Eukaryotic phosphomannomutase Hydrolase_3 PF08282.12 CCF49162.1 - 9.2e-05 22.3 0.0 0.0024 17.7 0.0 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Mre11_DNA_bind PF04152.14 CCF49163.1 - 8.1e-45 153.2 0.1 8.1e-45 153.2 0.1 2.2 3 0 0 3 3 3 1 Mre11 DNA-binding presumed domain Metallophos PF00149.28 CCF49163.1 - 2.1e-13 51.2 0.2 3.8e-13 50.4 0.2 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 CCF49163.1 - 2.1e-05 24.8 0.2 0.00067 19.9 0.2 2.7 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain NAT PF04768.13 CCF49164.1 - 3.7e-32 111.3 0.2 2.9e-20 72.6 0.0 2.3 2 0 0 2 2 2 2 NAT, N-acetyltransferase, of N-acetylglutamate synthase EccE PF11203.8 CCF49164.1 - 2.7 8.4 5.1 14 6.1 1.8 2.6 2 0 0 2 2 2 0 Putative type VII ESX secretion system translocon, EccE RVT_2 PF07727.14 CCF49166.1 - 2.6e-38 132.0 0.1 4.9e-38 131.1 0.1 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Asparaginase_2 PF01112.18 CCF49168.1 - 0.035 13.1 0.0 0.036 13.1 0.0 1.0 1 0 0 1 1 1 0 Asparaginase Pec_lyase_C PF00544.19 CCF49169.1 - 1.2e-10 41.3 0.1 3.1e-09 36.7 0.1 2.4 1 1 0 1 1 1 1 Pectate lyase Beta_helix PF13229.6 CCF49169.1 - 0.00099 19.0 0.2 0.013 15.4 0.1 2.2 1 1 1 2 2 2 1 Right handed beta helix region TCP PF03634.13 CCF49169.1 - 0.25 11.9 16.6 0.046 14.3 12.8 1.7 2 0 0 2 2 2 0 TCP family transcription factor RR_TM4-6 PF06459.12 CCF49169.1 - 0.42 10.4 21.8 0.066 13.0 18.1 1.6 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 Neur_chan_memb PF02932.16 CCF49169.1 - 0.94 9.5 8.1 1.6 8.7 8.1 1.5 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DDHD PF02862.17 CCF49169.1 - 1.2 9.3 10.9 2.5 8.2 10.9 1.6 1 0 0 1 1 1 0 DDHD domain SAPS PF04499.15 CCF49169.1 - 2.6 6.8 11.5 3.4 6.3 11.5 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Med11 PF10280.9 CCF49170.1 - 0.41 11.1 6.3 0.15 12.5 1.6 2.8 2 0 0 2 2 2 0 Mediator complex protein rve PF00665.26 CCF49172.1 - 2.6e-07 30.8 0.9 0.00013 22.1 0.9 2.5 1 1 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 CCF49172.1 - 0.011 15.5 0.2 0.031 14.1 0.0 1.8 2 0 0 2 2 2 0 Integrase core domain Acetyltransf_9 PF13527.7 CCF49174.1 - 0.017 15.2 0.2 3.9 7.6 0.1 2.3 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain OPT PF03169.15 CCF49175.1 - 6e-99 332.4 41.1 7e-99 332.2 41.1 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein DUF2207 PF09972.9 CCF49175.1 - 0.68 8.6 4.1 13 4.4 0.1 3.3 3 0 0 3 3 3 0 Predicted membrane protein (DUF2207) DNase_NucA_NucB PF14040.6 CCF49176.1 - 1.7e-16 60.6 1.3 1.7e-16 60.6 1.3 1.7 2 0 0 2 2 2 1 Deoxyribonuclease NucA/NucB UBX PF00789.20 CCF49177.1 - 0.00046 20.3 0.0 0.00082 19.5 0.0 1.5 1 0 0 1 1 1 1 UBX domain ArAE_2 PF10334.9 CCF49178.1 - 3.7e-56 190.5 9.7 6.1e-55 186.5 0.0 3.4 2 1 1 3 3 2 1 Aromatic acid exporter family member 2 ArAE_2_N PF10337.9 CCF49178.1 - 2.4e-44 152.2 26.9 5.2e-40 137.9 0.9 4.7 4 1 0 4 4 4 2 Putative ER transporter, 6TM, N-terminal FUSC_2 PF13515.6 CCF49178.1 - 1.8e-09 37.8 11.2 1.8e-09 37.8 11.2 3.3 3 0 0 3 3 3 1 Fusaric acid resistance protein-like Spt20 PF12090.8 CCF49178.1 - 0.065 12.8 50.3 0.0087 15.7 32.8 2.4 2 0 0 2 2 2 0 Spt20 family SID-1_RNA_chan PF13965.6 CCF49178.1 - 0.27 9.6 0.0 0.27 9.6 0.0 1.8 2 0 0 2 2 1 0 dsRNA-gated channel SID-1 PepSY_TM_like_2 PF16357.5 CCF49178.1 - 0.3 11.0 3.8 0.94 9.4 3.8 1.8 1 0 0 1 1 1 0 Putative PepSY_TM-like Glyoxalase_6 PF18029.1 CCF49178.1 - 0.39 11.5 8.0 0.36 11.6 0.5 2.7 2 0 0 2 2 2 0 Glyoxalase-like domain OATP PF03137.20 CCF49178.1 - 1.4 7.2 5.2 13 3.9 6.2 1.9 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family Presenilin PF01080.17 CCF49178.1 - 1.6 7.5 0.0 1.6 7.5 0.0 3.2 4 0 0 4 4 4 0 Presenilin CLN3 PF02487.17 CCF49178.1 - 2 7.4 11.9 0.23 10.4 5.0 2.3 2 0 0 2 2 2 0 CLN3 protein DDHD PF02862.17 CCF49178.1 - 2.3 8.3 21.3 0.03 14.5 4.0 3.4 3 1 0 3 3 3 0 DDHD domain SpoIIP PF07454.11 CCF49178.1 - 2.8 7.3 20.7 0.41 10.1 9.5 2.6 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) Membralin PF09746.9 CCF49178.1 - 5.6 5.9 6.1 15 4.5 6.1 1.6 1 0 0 1 1 1 0 Tumour-associated protein CMAS PF02353.20 CCF49179.1 - 2.1e-37 128.9 2.6 3.2e-37 128.3 2.6 1.3 1 1 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_25 PF13649.6 CCF49179.1 - 4.7e-15 56.1 0.0 1.2e-14 54.7 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF49179.1 - 4.1e-14 53.0 0.0 9.7e-14 51.8 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF49179.1 - 1e-12 48.1 0.0 4.7e-12 46.0 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCF49179.1 - 2.1e-12 47.2 0.1 4.1e-12 46.2 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF49179.1 - 9.9e-11 42.3 0.0 5.1e-10 40.0 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 CCF49179.1 - 3.5e-07 29.9 0.0 6.5e-07 29.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_4 PF02390.17 CCF49179.1 - 3e-05 23.6 0.0 5.8e-05 22.6 0.0 1.5 1 0 0 1 1 1 1 Putative methyltransferase TehB PF03848.14 CCF49179.1 - 5.6e-05 22.6 0.0 0.00011 21.7 0.0 1.4 1 0 0 1 1 1 1 Tellurite resistance protein TehB Methyltransf_2 PF00891.18 CCF49179.1 - 0.0021 17.4 0.0 0.0031 16.8 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase domain DUF938 PF06080.12 CCF49179.1 - 0.027 14.2 0.0 0.052 13.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF938) GidB PF02527.15 CCF49179.1 - 0.037 13.4 0.0 0.14 11.5 0.0 1.8 2 0 0 2 2 2 0 rRNA small subunit methyltransferase G MetW PF07021.12 CCF49179.1 - 0.087 12.4 0.0 0.19 11.3 0.0 1.5 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW FtsJ PF01728.19 CCF49179.1 - 0.12 12.5 0.0 0.21 11.7 0.0 1.4 1 0 0 1 1 1 0 FtsJ-like methyltransferase FTO_CTD PF12934.7 CCF49179.1 - 0.18 11.6 3.3 0.11 12.2 1.3 1.7 2 0 0 2 2 2 0 FTO C-terminal domain tRNA_int_end_N2 PF12928.7 CCF49180.1 - 1.1e-19 70.3 0.0 3.2e-19 68.9 0.0 1.8 1 0 0 1 1 1 1 tRNA-splicing endonuclease subunit sen54 N-term DUF3439 PF11921.8 CCF49180.1 - 0.059 13.3 12.0 0.13 12.2 12.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) SSP160 PF06933.11 CCF49180.1 - 1.8 6.7 15.9 2.9 6.0 15.9 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 PTS_2-RNA PF01885.16 CCF49181.1 - 6.4e-64 215.3 0.2 1.2e-63 214.5 0.2 1.4 1 1 0 1 1 1 1 RNA 2'-phosphotransferase, Tpt1 / KptA family DUF4551 PF15087.6 CCF49181.1 - 0.15 10.9 0.4 0.18 10.6 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) SET PF00856.28 CCF49182.1 - 0.00078 19.9 0.0 0.00094 19.6 0.0 1.3 1 0 0 1 1 1 1 SET domain V-ATPase_C PF03223.15 CCF49183.1 - 7.8e-122 407.2 2.1 8.8e-122 407.1 2.1 1.0 1 0 0 1 1 1 1 V-ATPase subunit C DUF4110 PF13422.6 CCF49183.1 - 0.021 14.9 1.4 0.057 13.5 1.4 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4110) RRM_1 PF00076.22 CCF49184.1 - 1.1e-14 54.0 0.0 5.7e-07 29.3 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CCF49184.1 - 2.3e-09 37.3 0.0 5.1e-09 36.1 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif Trypan_PARP PF05887.11 CCF49184.1 - 7.8 6.5 14.2 0.088 12.8 5.5 2.1 3 0 0 3 3 3 0 Procyclic acidic repetitive protein (PARP) adh_short PF00106.25 CCF49185.1 - 9.2e-34 116.6 0.8 1.6e-33 115.8 0.8 1.4 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF49185.1 - 2.4e-24 86.2 0.6 3e-24 85.9 0.6 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF49185.1 - 2.7e-11 43.7 0.2 3.8e-11 43.2 0.2 1.2 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 CCF49185.1 - 0.0061 16.0 0.0 0.0078 15.6 0.0 1.1 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) DUF3369 PF11849.8 CCF49185.1 - 0.091 13.0 0.1 0.42 10.8 0.0 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF3369) Fasciclin PF02469.22 CCF49186.1 - 3.4e-26 91.9 1.8 2.9e-19 69.5 0.2 2.4 2 1 0 2 2 2 2 Fasciclin domain Orf78 PF06024.12 CCF49187.1 - 0.16 12.3 0.0 0.32 11.3 0.0 1.5 1 0 0 1 1 1 0 Orf78 (ac78) Rhomboid PF01694.22 CCF49188.1 - 6.7e-11 42.4 17.5 6.7e-11 42.4 17.5 2.5 2 1 0 2 2 2 1 Rhomboid family RNA_pol_Rpb4 PF03874.16 CCF49189.1 - 2.8e-10 40.6 1.5 9.2e-10 38.9 1.5 1.8 1 1 0 1 1 1 1 RNA polymerase Rpb4 DUF1002 PF06207.11 CCF49189.1 - 0.099 12.2 0.3 0.13 11.8 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1002) WD40 PF00400.32 CCF49190.1 - 1.8e-43 145.6 13.7 2.9e-07 31.1 0.0 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF49190.1 - 4e-20 71.9 1.5 0.0015 18.7 0.0 5.7 1 1 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 CCF49190.1 - 1.5e-11 43.7 13.5 0.015 13.9 1.8 5.1 1 1 3 4 4 4 4 Nucleoporin Nup120/160 eIF2A PF08662.11 CCF49190.1 - 6.8e-08 32.6 2.3 0.0014 18.5 0.0 3.8 2 1 0 3 3 3 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 CCF49190.1 - 9.4e-08 31.4 5.0 0.49 9.3 0.1 5.4 2 1 3 6 6 6 3 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 CCF49190.1 - 0.00042 19.8 0.1 0.094 12.0 0.0 2.9 2 1 1 3 3 3 2 WD40-like domain Frtz PF11768.8 CCF49190.1 - 0.014 13.8 0.5 0.11 10.8 0.0 2.3 2 1 1 3 3 3 0 WD repeat-containing and planar cell polarity effector protein Fritz DUF5570 PF17731.1 CCF49190.1 - 0.063 13.4 4.5 0.1 12.7 1.0 2.8 2 1 1 3 3 3 0 Family of unknown function (DUF5570) Nbas_N PF15492.6 CCF49190.1 - 0.65 9.3 4.9 4.7 6.5 0.2 3.4 3 1 1 4 4 4 0 Neuroblastoma-amplified sequence, N terminal DUF1295 PF06966.12 CCF49191.1 - 6.9e-35 120.7 3.6 7.9e-34 117.2 3.6 2.2 1 1 0 1 1 1 1 Protein of unknown function (DUF1295) LrgB PF04172.16 CCF49191.1 - 0.056 12.9 5.2 0.2 11.2 0.4 2.9 3 0 0 3 3 3 0 LrgB-like family ICMT PF04140.14 CCF49191.1 - 8.4 6.9 8.0 0.72 10.3 0.1 3.1 4 0 0 4 4 4 0 Isoprenylcysteine carboxyl methyltransferase (ICMT) family Kinesin PF00225.23 CCF49192.1 - 4.9e-106 354.4 0.2 4.9e-106 354.4 0.2 2.0 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 CCF49192.1 - 1.4e-24 86.7 0.2 6.2e-24 84.6 0.0 2.3 2 0 0 2 2 2 1 Microtubule binding Flu_NS2 PF00601.19 CCF49192.1 - 0.47 10.8 3.3 1.8 8.9 2.4 2.5 1 1 0 1 1 1 0 Influenza non-structural protein (NS2) DUF3578 PF12102.8 CCF49192.1 - 1.7 8.2 6.0 2.2 7.8 1.2 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3578) SAICAR_synt PF01259.18 CCF49193.1 - 1.2e-91 306.8 0.0 1.5e-91 306.5 0.0 1.0 1 0 0 1 1 1 1 SAICAR synthetase Kinesin PF00225.23 CCF49194.1 - 2.6e-82 276.4 0.0 5.8e-82 275.3 0.0 1.6 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 CCF49194.1 - 6.1e-11 42.5 0.6 3.9e-07 30.1 0.0 3.1 3 0 0 3 3 3 2 Microtubule binding Lon_2 PF13337.6 CCF49195.1 - 0.13 10.8 0.0 0.14 10.7 0.0 1.0 1 0 0 1 1 1 0 Putative ATP-dependent Lon protease RIO1 PF01163.22 CCF49200.1 - 6.4e-41 140.0 0.1 2.3e-28 99.1 0.0 2.3 2 0 0 2 2 2 2 RIO1 family Rio2_N PF09202.11 CCF49200.1 - 4.5e-33 113.3 0.1 1e-32 112.2 0.1 1.6 1 0 0 1 1 1 1 Rio2, N-terminal APH PF01636.23 CCF49200.1 - 8.1e-08 32.5 0.7 7.5e-05 22.8 0.1 2.8 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 CCF49200.1 - 0.00017 21.0 0.0 0.12 11.7 0.0 2.3 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family MarR_2 PF12802.7 CCF49200.1 - 0.021 14.7 0.0 0.23 11.4 0.0 2.4 2 0 0 2 2 2 0 MarR family SDA1 PF05285.12 CCF49200.1 - 0.32 10.4 27.6 0.046 13.1 14.7 2.3 2 0 0 2 2 2 0 SDA1 YL1 PF05764.13 CCF49200.1 - 2.5 8.2 26.4 0.98 9.5 16.2 2.4 2 0 0 2 2 2 0 YL1 nuclear protein E1_DerP2_DerF2 PF02221.15 CCF49201.1 - 1.8e-25 89.9 0.0 2.5e-25 89.4 0.0 1.2 1 0 0 1 1 1 1 ML domain DUF4097 PF13349.6 CCF49202.1 - 0.0083 15.5 1.5 0.023 14.1 1.6 1.6 1 1 0 1 1 1 1 Putative adhesin OppC_N PF12911.7 CCF49202.1 - 0.15 12.0 0.0 0.33 11.0 0.0 1.5 1 0 0 1 1 1 0 N-terminal TM domain of oligopeptide transport permease C PPR_2 PF13041.6 CCF49203.1 - 3.1e-36 123.3 1.6 2.1e-07 31.0 0.0 8.5 8 1 1 9 9 9 6 PPR repeat family PPR_1 PF12854.7 CCF49203.1 - 2.1e-24 84.9 4.2 9.6e-07 28.4 0.3 9.8 11 0 0 11 11 11 5 PPR repeat PPR_3 PF13812.6 CCF49203.1 - 5.7e-22 77.6 0.1 1.7e-07 31.2 0.0 6.3 5 1 1 6 6 6 5 Pentatricopeptide repeat domain PPR PF01535.20 CCF49203.1 - 2.1e-20 71.5 17.5 4.1e-06 26.7 0.6 11.2 12 0 0 12 12 12 3 PPR repeat PPR_long PF17177.4 CCF49203.1 - 2e-05 24.1 1.7 0.44 9.9 0.0 3.8 1 1 1 3 3 3 2 Pentacotripeptide-repeat region of PRORP TPR_19 PF14559.6 CCF49203.1 - 0.0029 18.1 2.9 1.8 9.2 0.0 5.2 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_14 PF13428.6 CCF49203.1 - 0.0063 17.2 9.9 32 5.7 0.0 7.3 7 0 0 7 7 7 0 Tetratricopeptide repeat Snf7 PF03357.21 CCF49204.1 - 7.6e-33 113.5 10.6 8.9e-33 113.3 10.6 1.1 1 0 0 1 1 1 1 Snf7 Peptidase_M24 PF00557.24 CCF49206.1 - 2.8e-48 164.4 0.0 4.9e-48 163.6 0.0 1.4 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.16 CCF49206.1 - 3.7e-40 136.5 0.0 7.1e-40 135.6 0.0 1.5 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain GST_N_3 PF13417.6 CCF49207.1 - 2.9e-12 46.8 0.0 2.6e-11 43.8 0.0 2.4 3 0 0 3 3 3 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 CCF49207.1 - 8.8e-08 32.3 0.0 1.8e-07 31.3 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 CCF49207.1 - 5.1e-07 29.6 0.1 1.7e-06 27.9 0.1 2.0 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 CCF49207.1 - 5.9e-05 23.3 0.0 0.00019 21.7 0.0 2.0 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 CCF49207.1 - 0.00022 21.4 0.0 0.00045 20.4 0.0 1.6 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 CCF49207.1 - 0.0022 18.2 0.0 0.006 16.8 0.0 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_5 PF16865.5 CCF49207.1 - 0.017 15.7 0.0 0.043 14.4 0.0 1.8 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain TipAS PF07739.13 CCF49207.1 - 0.18 12.3 0.4 0.54 10.8 0.3 1.7 1 1 0 1 1 1 0 TipAS antibiotic-recognition domain DASH_Dad3 PF08656.10 CCF49207.1 - 0.22 11.6 3.3 4 7.6 3.3 2.4 1 1 0 1 1 1 0 DASH complex subunit Dad3 IlvN PF07991.12 CCF49208.1 - 1.4e-44 151.6 0.0 2.3e-44 150.8 0.0 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain IlvC PF01450.19 CCF49208.1 - 2.1e-42 144.8 0.0 3.4e-42 144.2 0.0 1.4 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain F420_oxidored PF03807.17 CCF49208.1 - 0.00093 19.7 0.0 0.0021 18.6 0.0 1.6 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_2 PF03446.15 CCF49208.1 - 0.072 13.3 0.0 0.17 12.1 0.0 1.6 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase Oxidored_nitro PF00148.19 CCF49208.1 - 0.15 10.8 0.0 0.23 10.1 0.0 1.2 1 0 0 1 1 1 0 Nitrogenase component 1 type Oxidoreductase KRTAP PF11759.8 CCF49208.1 - 1.8 9.2 12.9 0.4 11.2 3.6 3.2 3 0 0 3 3 3 0 Keratin-associated matrix PRR18 PF15671.5 CCF49208.1 - 5.9 6.7 8.1 9 6.1 8.1 1.2 1 0 0 1 1 1 0 Proline-rich protein family 18 Amino_oxidase PF01593.24 CCF49211.1 - 5.9e-09 35.7 0.0 0.0019 17.6 0.0 2.4 2 1 0 2 2 2 2 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 CCF49211.1 - 7.3e-09 35.7 0.0 2e-08 34.3 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CCF49211.1 - 0.012 15.2 0.0 0.035 13.7 0.0 1.8 1 0 0 1 1 1 0 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CCF49211.1 - 0.15 11.3 0.1 0.29 10.3 0.0 1.5 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CCF49211.1 - 0.16 12.5 0.0 0.43 11.2 0.0 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase RRS1 PF04939.12 CCF49213.1 - 6.6e-55 185.4 4.6 6.6e-55 185.4 4.6 1.9 2 0 0 2 2 2 1 Ribosome biogenesis regulatory protein (RRS1) WD40 PF00400.32 CCF49214.1 - 1.3e-39 133.4 17.8 1.1e-08 35.5 1.0 8.6 8 0 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF49214.1 - 4.6e-14 52.5 0.0 5.9e-05 23.3 0.0 4.5 2 1 2 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 CCF49214.1 - 5e-05 23.3 0.0 0.13 12.2 0.0 3.2 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 CCF49214.1 - 0.023 14.6 0.5 57 3.8 0.0 4.2 3 1 0 3 3 3 0 WD40-like Beta Propeller Repeat MIF4G PF02854.19 CCF49215.1 - 3.2e-23 82.5 0.1 3.2e-23 82.5 0.1 2.7 3 0 0 3 3 3 1 MIF4G domain MA3 PF02847.17 CCF49215.1 - 7e-14 51.8 0.0 1.4e-13 50.8 0.0 1.6 1 0 0 1 1 1 1 MA3 domain PXA PF02194.15 CCF49215.1 - 0.11 12.5 0.1 0.11 12.5 0.1 2.6 2 0 0 2 2 2 0 PXA domain DEAD PF00270.29 CCF49216.1 - 2.7e-41 141.3 0.0 5e-41 140.4 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CCF49216.1 - 6.5e-32 110.2 0.0 3.2e-28 98.3 0.0 2.7 2 0 0 2 2 2 2 Helicase conserved C-terminal domain ResIII PF04851.15 CCF49216.1 - 6.7e-08 32.7 0.0 1.8e-07 31.3 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 CCF49216.1 - 0.0003 21.1 0.0 0.00089 19.6 0.0 1.8 1 1 1 2 2 2 1 AAA domain AAA_22 PF13401.6 CCF49216.1 - 0.0069 16.7 0.3 0.036 14.4 0.0 2.3 2 1 0 2 2 2 1 AAA domain Terminase_6 PF03237.15 CCF49216.1 - 0.009 15.7 0.0 0.14 11.8 0.0 2.2 2 0 0 2 2 2 1 Terminase-like family Herpes_ori_bp PF02399.15 CCF49216.1 - 0.067 11.2 0.0 0.1 10.7 0.0 1.2 1 0 0 1 1 1 0 Origin of replication binding protein Presenilin PF01080.17 CCF49216.1 - 4 6.1 5.9 8.3 5.0 5.9 1.4 1 0 0 1 1 1 0 Presenilin F-box-like PF12937.7 CCF49217.1 - 9.6e-10 38.2 1.3 9.6e-10 38.2 1.3 1.9 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 CCF49217.1 - 1.8e-06 27.7 0.6 1.8e-06 27.7 0.6 2.1 2 0 0 2 2 2 1 F-box domain WD40 PF00400.32 CCF49217.1 - 0.0016 19.2 0.9 0.021 15.7 1.0 2.9 2 0 0 2 2 2 1 WD domain, G-beta repeat F-box_4 PF15966.5 CCF49217.1 - 0.073 12.9 0.0 0.18 11.7 0.0 1.5 1 0 0 1 1 1 0 F-box Pkinase PF00069.25 CCF49218.1 - 1.9e-61 207.7 3.6 5.8e-58 196.3 0.0 2.9 3 0 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 CCF49218.1 - 2.1e-40 138.6 0.0 3.1e-37 128.3 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 CCF49218.1 - 6.8e-07 28.9 0.0 1.1e-06 28.2 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 CCF49218.1 - 0.0001 21.3 0.0 0.0001 21.3 0.0 4.1 4 0 0 4 4 4 1 Fungal protein kinase Kdo PF06293.14 CCF49218.1 - 0.03 13.7 0.0 0.073 12.4 0.0 1.6 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pox_ser-thr_kin PF05445.11 CCF49218.1 - 0.057 12.4 0.1 0.057 12.4 0.1 1.5 2 0 0 2 2 2 0 Poxvirus serine/threonine protein kinase APH PF01636.23 CCF49218.1 - 0.14 12.1 2.5 0.14 12.1 0.1 2.3 2 1 0 2 2 2 0 Phosphotransferase enzyme family UPF1_Zn_bind PF09416.10 CCF49218.1 - 0.15 12.0 0.0 0.15 12.0 0.0 1.8 2 0 0 2 2 2 0 RNA helicase (UPF2 interacting domain) MBF1 PF08523.10 CCF49219.1 - 6.1e-20 71.5 0.9 1.5e-19 70.2 0.9 1.7 1 0 0 1 1 1 1 Multiprotein bridging factor 1 HTH_3 PF01381.22 CCF49219.1 - 1.3e-12 47.5 0.2 2.4e-12 46.7 0.2 1.4 1 0 0 1 1 1 1 Helix-turn-helix HTH_31 PF13560.6 CCF49219.1 - 8.3e-05 22.9 0.0 0.00016 21.9 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_19 PF12844.7 CCF49219.1 - 0.064 13.3 0.0 0.17 11.9 0.1 1.7 2 0 0 2 2 2 0 Helix-turn-helix domain Response_reg PF00072.24 CCF49220.1 - 2.2e-19 69.7 0.0 5.9e-19 68.3 0.0 1.8 2 0 0 2 2 2 1 Response regulator receiver domain HATPase_c PF02518.26 CCF49220.1 - 9.2e-15 55.1 0.1 2.7e-14 53.6 0.1 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 CCF49220.1 - 1.6e-06 28.1 0.1 4.5e-06 26.6 0.1 1.8 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain zf-ZPR1 PF03367.13 CCF49221.1 - 4.7e-110 364.5 1.8 1.9e-55 187.1 0.0 3.0 2 1 0 2 2 2 2 ZPR1 zinc-finger domain DZR PF12773.7 CCF49221.1 - 0.0019 18.2 5.4 0.23 11.5 0.2 3.3 3 0 0 3 3 3 1 Double zinc ribbon HypA PF01155.19 CCF49221.1 - 0.0026 17.8 2.0 0.95 9.5 0.2 2.4 2 0 0 2 2 2 2 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-ribbon_3 PF13248.6 CCF49221.1 - 0.011 15.1 9.3 2.2 7.8 0.3 3.5 3 0 0 3 3 3 0 zinc-ribbon domain zinc-ribbons_6 PF07191.12 CCF49221.1 - 0.037 14.0 2.2 3.8 7.6 0.1 2.6 2 1 0 2 2 2 0 zinc-ribbons Paired_CXXCH_1 PF09699.10 CCF49221.1 - 0.16 11.7 0.8 0.36 10.6 0.0 2.0 2 0 0 2 2 2 0 Doubled CXXCH motif (Paired_CXXCH_1) zinc_ribbon_2 PF13240.6 CCF49221.1 - 0.19 11.5 12.3 0.27 11.0 0.6 3.9 4 0 0 4 4 4 0 zinc-ribbon domain OrfB_Zn_ribbon PF07282.11 CCF49221.1 - 0.63 10.0 3.9 12 5.9 0.0 2.9 3 0 0 3 3 3 0 Putative transposase DNA-binding domain eIF-5_eIF-2B PF01873.17 CCF49221.1 - 2.8 7.8 4.9 9.2 6.2 0.3 3.3 3 1 0 3 3 3 0 Domain found in IF2B/IF5 Pro_isomerase PF00160.21 CCF49222.1 - 2.3e-41 141.7 0.0 3.9e-41 140.9 0.0 1.4 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Rtf2 PF04641.12 CCF49222.1 - 8.7e-06 25.3 3.4 2.7e-05 23.6 0.0 2.5 2 1 0 2 2 2 1 Rtf2 RING-finger zf-NOSIP PF15906.5 CCF49222.1 - 0.0069 16.5 0.0 0.018 15.1 0.0 1.7 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein SPX PF03105.19 CCF49223.1 - 1.7e-30 107.2 34.8 2e-18 67.5 29.4 3.4 1 1 1 2 2 2 2 SPX domain Na_sulph_symp PF00939.19 CCF49223.1 - 2.5e-30 106.0 36.1 3.5e-30 105.5 36.1 1.1 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.16 CCF49223.1 - 1.9e-28 99.6 30.9 1.9e-28 99.6 30.9 2.0 1 1 1 2 2 2 1 Citrate transporter DUF997 PF06196.12 CCF49223.1 - 0.068 13.2 0.1 0.068 13.2 0.1 3.7 4 0 0 4 4 4 0 Protein of unknown function (DUF997) ATPase_gene1 PF09527.10 CCF49223.1 - 0.27 11.4 5.2 1.9 8.7 5.2 2.5 1 0 0 1 1 1 0 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter RRN3 PF05327.11 CCF49223.1 - 2.6 6.5 6.2 1.5 7.3 4.4 1.4 2 0 0 2 2 2 0 RNA polymerase I specific transcription initiation factor RRN3 CAF1C_H4-bd PF12265.8 CCF49224.1 - 1.9e-31 108.1 0.5 5.9e-31 106.5 0.5 1.9 1 0 0 1 1 1 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 CCF49224.1 - 2.1e-27 94.8 6.1 4.9e-06 27.2 0.1 5.7 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF49224.1 - 1.8e-06 28.1 0.2 0.018 15.3 0.0 4.2 3 2 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain NAP PF00956.18 CCF49225.1 - 5e-22 78.4 10.4 1e-20 74.1 5.5 3.3 2 1 1 3 3 3 2 Nucleosome assembly protein (NAP) HSDR_N_2 PF13588.6 CCF49225.1 - 0.0011 19.0 0.2 0.0018 18.3 0.2 1.3 1 0 0 1 1 1 1 Type I restriction enzyme R protein N terminus (HSDR_N) FRQ PF09421.10 CCF49225.1 - 0.042 11.9 1.1 0.052 11.6 1.1 1.1 1 0 0 1 1 1 0 Frequency clock protein YL1 PF05764.13 CCF49225.1 - 0.21 11.7 7.3 0.27 11.3 7.3 1.2 1 0 0 1 1 1 0 YL1 nuclear protein NOA36 PF06524.12 CCF49225.1 - 2.9 7.1 10.7 4.3 6.6 10.7 1.3 1 0 0 1 1 1 0 NOA36 protein DUF4611 PF15387.6 CCF49225.1 - 4 7.7 9.9 9.8 6.5 9.9 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) DUF3292 PF11696.8 CCF49226.1 - 1.8e-10 39.9 6.5 7.2e-06 24.7 0.8 3.4 2 1 1 3 3 3 3 Protein of unknown function (DUF3292) Methyltransf_4 PF02390.17 CCF49227.1 - 5.6e-48 162.7 0.0 1.9e-36 125.1 0.0 2.1 2 0 0 2 2 2 2 Putative methyltransferase Methyltransf_25 PF13649.6 CCF49227.1 - 0.0074 17.0 0.0 0.097 13.4 0.0 2.3 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF49227.1 - 0.02 15.5 0.0 2.9 8.6 0.0 2.5 2 0 0 2 2 2 0 Methyltransferase domain MTS PF05175.14 CCF49227.1 - 0.022 14.3 0.0 1.7 8.2 0.0 2.2 2 0 0 2 2 2 0 Methyltransferase small domain Methyltransf_31 PF13847.6 CCF49227.1 - 0.092 12.5 0.0 0.3 10.9 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_12 PF08242.12 CCF49227.1 - 0.16 12.8 0.0 0.42 11.4 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase domain NDUFB10 PF10249.9 CCF49228.1 - 0.02 15.4 0.4 0.022 15.2 0.4 1.2 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase subunit 10 CheZ PF04344.13 CCF49228.1 - 0.08 12.8 0.5 0.088 12.7 0.5 1.1 1 0 0 1 1 1 0 Chemotaxis phosphatase, CheZ BK_channel_a PF03493.18 CCF49228.1 - 0.12 12.6 0.1 0.15 12.3 0.1 1.1 1 0 0 1 1 1 0 Calcium-activated BK potassium channel alpha subunit Prefoldin_2 PF01920.20 CCF49229.1 - 9e-22 77.0 3.9 9e-22 77.0 3.9 1.5 1 1 1 2 2 2 1 Prefoldin subunit Prefoldin PF02996.17 CCF49229.1 - 0.0025 17.7 4.1 0.0025 17.7 4.1 2.1 1 1 1 2 2 2 1 Prefoldin subunit TMF_TATA_bd PF12325.8 CCF49229.1 - 0.0043 17.3 2.1 0.0043 17.3 2.1 1.9 1 1 1 2 2 2 1 TATA element modulatory factor 1 TATA binding MelC1 PF06236.11 CCF49229.1 - 0.035 14.2 1.2 0.046 13.8 1.2 1.1 1 0 0 1 1 1 0 Tyrosinase co-factor MelC1 Cep57_MT_bd PF06657.13 CCF49229.1 - 0.13 12.8 5.8 0.15 12.5 0.9 2.6 2 1 1 3 3 3 0 Centrosome microtubule-binding domain of Cep57 APG6_N PF17675.1 CCF49229.1 - 1.5 9.3 11.2 0.45 11.0 1.8 2.1 2 0 0 2 2 2 0 Apg6 coiled-coil region DUF1451 PF07295.11 CCF49229.1 - 2.3 8.3 7.2 0.97 9.5 1.9 2.0 2 0 0 2 2 2 0 Zinc-ribbon containing domain CH PF00307.31 CCF49230.1 - 5.9e-82 271.0 0.0 7.2e-21 74.4 0.0 4.2 4 0 0 4 4 4 4 Calponin homology (CH) domain EF-hand_7 PF13499.6 CCF49230.1 - 2.2e-06 28.0 1.5 3.6e-06 27.3 0.2 2.0 2 0 0 2 2 2 1 EF-hand domain pair CAMSAP_CH PF11971.8 CCF49230.1 - 4.7e-06 26.3 0.0 0.64 9.9 0.0 4.1 4 0 0 4 4 4 2 CAMSAP CH domain EF-hand_1 PF00036.32 CCF49230.1 - 0.001 18.4 1.0 0.095 12.3 0.0 3.3 3 0 0 3 3 3 1 EF hand EF-hand_6 PF13405.6 CCF49230.1 - 0.0098 15.8 0.4 35 4.7 0.0 3.7 3 0 0 3 3 3 0 EF-hand domain CH_2 PF06294.11 CCF49230.1 - 0.12 12.5 0.0 20 5.4 0.0 2.7 2 0 0 2 2 2 0 CH-like domain in sperm protein EF-hand_8 PF13833.6 CCF49230.1 - 0.13 12.1 0.0 0.43 10.5 0.0 1.9 1 0 0 1 1 1 0 EF-hand domain pair Abhydrolase_1 PF00561.20 CCF49231.1 - 1.7e-12 47.6 0.3 5e-11 42.7 0.3 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CCF49231.1 - 2e-08 33.8 0.2 4.2e-08 32.8 0.2 1.5 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 CCF49231.1 - 9e-07 29.7 0.0 1.2e-06 29.4 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 CCF49231.1 - 0.014 14.8 0.0 0.73 9.3 0.0 3.1 3 2 0 3 3 3 0 Prolyl oligopeptidase family FSH1 PF03959.13 CCF49231.1 - 0.024 14.3 0.2 0.2 11.3 0.2 2.0 1 1 0 1 1 1 0 Serine hydrolase (FSH1) Abhydrolase_2 PF02230.16 CCF49231.1 - 0.076 12.8 0.0 7.8 6.2 0.0 2.3 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase DUF346 PF03984.13 CCF49231.1 - 0.12 12.1 0.2 0.6 9.9 0.0 2.1 2 0 0 2 2 2 0 Repeat of unknown function (DUF346) Tudor_3 PF18115.1 CCF49232.1 - 1.8e-05 24.5 0.1 3.3e-05 23.6 0.1 1.4 1 0 0 1 1 1 1 DNA repair protein Crb2 Tudor domain TUDOR PF00567.24 CCF49232.1 - 9.9e-05 22.4 0.0 0.00043 20.3 0.0 1.9 1 1 1 2 2 2 1 Tudor domain DUF1325 PF07039.11 CCF49232.1 - 0.00011 22.3 0.4 0.00026 21.1 0.2 1.7 1 1 1 2 2 2 1 SGF29 tudor-like domain Na_H_Exchanger PF00999.21 CCF49233.1 - 1.7e-55 188.4 48.7 2.4e-55 187.9 48.7 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family Polysacc_deac_2 PF04748.13 CCF49233.1 - 0.068 12.3 0.0 0.14 11.3 0.0 1.4 1 0 0 1 1 1 0 Divergent polysaccharide deacetylase Response_reg PF00072.24 CCF49234.1 - 1.1e-20 73.9 0.0 3.8e-10 39.9 0.0 3.6 3 0 0 3 3 3 3 Response regulator receiver domain HATPase_c PF02518.26 CCF49234.1 - 1.5e-19 70.6 0.2 4e-19 69.2 0.2 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 CCF49234.1 - 5.3e-16 58.4 0.1 1.4e-15 57.0 0.1 1.8 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HATPase_c_3 PF13589.6 CCF49234.1 - 0.14 12.0 0.0 0.32 10.8 0.0 1.6 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase zf-H2C2_2 PF13465.6 CCF49235.1 - 2.2e-16 59.4 3.5 1.6e-06 28.2 0.1 3.8 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2 PF00096.26 CCF49235.1 - 9.1e-13 47.9 14.6 8.6e-05 22.8 0.0 4.3 3 1 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CCF49235.1 - 7e-12 45.1 10.7 0.00064 20.3 0.0 3.8 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 CCF49235.1 - 1.1e-05 25.5 1.4 0.67 10.3 0.0 3.9 3 1 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 CCF49235.1 - 0.00029 20.7 6.2 0.054 13.5 0.0 3.7 3 0 0 3 3 3 1 C2H2-type zinc finger IBR PF01485.21 CCF49235.1 - 0.021 15.1 0.3 0.05 13.8 0.3 1.6 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain zf-met PF12874.7 CCF49235.1 - 0.022 15.1 5.7 1.4 9.4 0.0 4.0 3 1 0 3 3 3 0 Zinc-finger of C2H2 type RRM_1 PF00076.22 CCF49236.1 - 8.6e-18 63.9 0.0 1.3e-17 63.3 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) U1snRNP70_N PF12220.8 CCF49236.1 - 1.1e-16 61.3 0.1 2.4e-16 60.2 0.1 1.6 1 0 0 1 1 1 1 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal eIF3_subunit PF08597.10 CCF49236.1 - 0.064 13.2 0.3 0.099 12.5 0.3 1.2 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit RRM_5 PF13893.6 CCF49236.1 - 0.089 12.4 0.0 0.14 11.8 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CCF49236.1 - 0.13 12.4 0.0 0.34 11.0 0.0 1.6 1 1 0 1 1 1 0 RNA recognition motif Proteasome PF00227.26 CCF49237.1 - 7.9e-51 172.3 0.0 1e-50 171.9 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 CCF49237.1 - 3.5e-12 45.8 0.2 5.6e-12 45.1 0.2 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature DUF2188 PF09954.9 CCF49237.1 - 1.3 9.2 6.0 29 4.9 0.2 3.5 2 1 1 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2188) NBP1 PF08537.10 CCF49239.1 - 0.16 11.3 0.1 0.24 10.8 0.1 1.2 1 0 0 1 1 1 0 Fungal Nap binding protein NBP1 FAP206 PF12018.8 CCF49240.1 - 0.00041 20.0 0.3 0.00049 19.7 0.3 1.1 1 0 0 1 1 1 1 Domain of unknown function Tom5 PF10642.9 CCF49241.1 - 0.015 15.3 0.9 0.044 13.8 0.9 1.8 1 0 0 1 1 1 0 Mitochondrial import receptor subunit or translocase ENOD93 PF03386.14 CCF49241.1 - 0.064 13.1 1.6 0.12 12.2 0.0 2.2 2 0 0 2 2 2 0 Early nodulin 93 ENOD93 protein LSM PF01423.22 CCF49243.1 - 4.9e-17 61.4 0.2 6.8e-17 60.9 0.2 1.2 1 0 0 1 1 1 1 LSM domain Hfq PF17209.3 CCF49243.1 - 0.037 13.7 0.0 0.063 12.9 0.0 1.4 1 0 0 1 1 1 0 Hfq protein Propep_M14 PF02244.16 CCF49243.1 - 0.11 12.9 0.7 0.14 12.5 0.7 1.2 1 0 0 1 1 1 0 Carboxypeptidase activation peptide Svf1_C PF17187.4 CCF49244.1 - 3e-55 186.5 0.0 5.2e-55 185.7 0.0 1.4 1 0 0 1 1 1 1 Svf1-like C-terminal lipocalin-like domain Svf1 PF08622.10 CCF49244.1 - 1.4e-42 145.6 0.1 2e-42 145.0 0.1 1.3 1 0 0 1 1 1 1 Svf1-like N-terminal lipocalin domain Aconitase PF00330.20 CCF49245.1 - 1e-111 374.2 0.0 1.1e-110 370.8 0.0 2.1 1 1 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 CCF49245.1 - 5.1e-20 72.1 0.0 3.9e-19 69.3 0.0 2.2 1 1 0 1 1 1 1 Aconitase C-terminal domain DUF521 PF04412.13 CCF49245.1 - 0.16 10.7 0.0 0.27 9.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF521) Cyclin_N PF00134.23 CCF49246.1 - 2e-37 127.8 0.1 3.4e-37 127.0 0.1 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 CCF49246.1 - 4e-08 33.4 1.4 7.1e-08 32.5 0.1 2.1 2 0 0 2 2 2 1 Cyclin, C-terminal domain SOG2 PF10428.9 CCF49246.1 - 1.5 8.0 26.0 0.25 10.5 14.9 2.1 2 0 0 2 2 2 0 RAM signalling pathway protein FSA_C PF10479.9 CCF49246.1 - 5.9 4.9 11.3 1.1 7.3 7.5 1.6 2 0 0 2 2 2 0 Fragile site-associated protein C-terminus zf-LYAR PF08790.11 CCF49248.1 - 2.7e-12 46.3 2.0 6e-12 45.2 2.0 1.6 1 0 0 1 1 1 1 LYAR-type C2HC zinc finger RRM_1 PF00076.22 CCF49248.1 - 0.00028 20.6 0.0 0.0031 17.3 0.0 2.5 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf_UBZ PF18439.1 CCF49248.1 - 0.054 13.1 0.7 4.2 7.0 0.0 2.5 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger zf-C2H2_4 PF13894.6 CCF49248.1 - 1.8 9.6 6.7 8.1 7.6 0.8 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger GatB_N PF02934.15 CCF49249.1 - 5.7e-102 340.8 0.0 9.9e-102 340.0 0.0 1.4 1 0 0 1 1 1 1 GatB/GatE catalytic domain GatB_Yqey PF02637.18 CCF49249.1 - 8.4e-28 97.1 0.8 2.5e-27 95.6 0.8 1.8 1 1 0 1 1 1 1 GatB domain Beta_elim_lyase PF01212.21 CCF49250.1 - 5.4e-69 232.7 0.0 7.3e-69 232.3 0.0 1.1 1 0 0 1 1 1 1 Beta-eliminating lyase Pcc1 PF09341.10 CCF49250.1 - 1e-15 57.6 0.4 2.6e-15 56.3 0.0 1.9 2 0 0 2 2 2 1 Transcription factor Pcc1 Aminotran_1_2 PF00155.21 CCF49250.1 - 0.0017 17.6 0.0 0.0032 16.7 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 CCF49250.1 - 0.0058 16.0 0.0 0.0095 15.3 0.0 1.3 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family RPN2_C PF18004.1 CCF49251.1 - 1.9e-41 141.6 6.3 1.1e-40 139.1 5.4 2.4 2 0 0 2 2 2 1 26S proteasome regulatory subunit RPN2 C-terminal domain PC_rep PF01851.22 CCF49251.1 - 1.1e-38 129.7 17.1 8.5e-07 29.1 0.0 8.5 8 0 0 8 8 8 6 Proteasome/cyclosome repeat HEAT_2 PF13646.6 CCF49251.1 - 2.9e-17 62.8 11.6 7e-14 52.0 0.1 5.3 5 1 1 6 6 6 2 HEAT repeats HEAT_EZ PF13513.6 CCF49251.1 - 1.7e-06 28.4 0.3 0.057 13.9 0.0 4.9 3 1 1 4 4 4 2 HEAT-like repeat HEAT PF02985.22 CCF49251.1 - 0.0001 22.3 0.3 2.8 8.4 0.0 4.3 4 0 0 4 4 4 2 HEAT repeat HEAT_PBS PF03130.16 CCF49251.1 - 0.032 14.9 2.5 45 5.1 0.0 5.0 4 0 0 4 4 4 0 PBS lyase HEAT-like repeat Hus1 PF04005.12 CCF49252.1 - 6.1e-86 288.1 1.0 6.9e-86 288.0 1.0 1.0 1 0 0 1 1 1 1 Hus1-like protein PCNA_N PF00705.18 CCF49252.1 - 0.0034 17.1 0.2 0.0073 16.0 0.2 1.6 1 0 0 1 1 1 1 Proliferating cell nuclear antigen, N-terminal domain Rad9 PF04139.13 CCF49252.1 - 0.036 13.5 0.1 0.13 11.7 0.1 2.1 1 1 0 1 1 1 0 Rad9 VPS28 PF03997.12 CCF49253.1 - 3e-70 235.8 1.4 3.4e-70 235.6 1.4 1.0 1 0 0 1 1 1 1 VPS28 protein DUF4745 PF15923.5 CCF49253.1 - 0.013 15.5 0.1 0.41 10.6 0.0 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4745) ubiquitin PF00240.23 CCF49254.1 - 0.00065 19.4 0.0 0.0021 17.8 0.0 1.9 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD_2 PF13881.6 CCF49254.1 - 0.0016 18.6 0.0 0.0048 17.0 0.0 1.8 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 CCF49254.1 - 0.14 12.7 2.6 0.18 12.4 0.0 2.4 2 0 0 2 2 2 0 DUF2407 ubiquitin-like domain DUF2127 PF09900.9 CCF49254.1 - 0.16 12.2 0.3 0.32 11.3 0.3 1.5 1 0 0 1 1 1 0 Predicted membrane protein (DUF2127) tRNA-synt_1c PF00749.21 CCF49255.1 - 9.6e-111 369.6 0.0 1.5e-110 369.0 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.18 CCF49255.1 - 9.6e-34 116.7 0.2 1.9e-33 115.8 0.2 1.5 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain GST_C PF00043.25 CCF49255.1 - 0.00078 19.6 1.6 0.0022 18.2 0.0 2.4 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain efb-c PF12199.8 CCF49255.1 - 0.036 14.1 0.0 0.12 12.5 0.0 1.9 1 0 0 1 1 1 0 Extracellular fibrinogen binding protein C terminal GST_C_3 PF14497.6 CCF49255.1 - 0.036 14.3 0.9 0.41 10.9 0.0 3.1 3 1 0 3 3 3 0 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 CCF49255.1 - 0.068 13.2 0.1 0.19 11.8 0.1 1.9 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain IMUP PF15761.5 CCF49255.1 - 0.16 12.6 12.0 0.49 11.1 12.0 1.8 1 0 0 1 1 1 0 Immortalisation up-regulated protein TFIIB PF00382.19 CCF49256.1 - 8.2e-37 125.1 0.5 1e-21 76.8 0.2 2.3 2 0 0 2 2 2 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.12 CCF49256.1 - 4.9e-13 48.4 1.5 8e-13 47.7 1.5 1.4 1 0 0 1 1 1 1 TFIIB zinc-binding Cyclin_C PF02984.19 CCF49256.1 - 0.002 18.2 0.0 0.049 13.7 0.0 2.3 2 0 0 2 2 2 1 Cyclin, C-terminal domain RB_B PF01857.20 CCF49256.1 - 0.0063 16.5 0.1 0.011 15.8 0.1 1.3 1 0 0 1 1 1 1 Retinoblastoma-associated protein B domain PG_binding_1 PF01471.18 CCF49256.1 - 0.08 13.2 0.3 0.21 11.8 0.1 1.7 2 0 0 2 2 2 0 Putative peptidoglycan binding domain Cyclin_N PF00134.23 CCF49256.1 - 0.16 11.7 0.0 0.27 11.0 0.0 1.3 1 0 0 1 1 1 0 Cyclin, N-terminal domain YjbE PF11106.8 CCF49256.1 - 0.19 11.9 4.4 0.08 13.2 1.6 1.8 2 0 0 2 2 2 0 Exopolysaccharide production protein YjbE Nup84_Nup100 PF04121.13 CCF49257.1 - 6.7e-166 553.5 0.0 7.9e-166 553.2 0.0 1.0 1 0 0 1 1 1 1 Nuclear pore protein 84 / 107 C2 PF00168.30 CCF49258.1 - 1.1e-23 83.5 0.0 1.5e-13 50.9 0.0 2.7 3 0 0 3 3 3 2 C2 domain Ribul_P_3_epim PF00834.19 CCF49259.1 - 3.3e-61 206.1 0.1 4.3e-61 205.8 0.1 1.1 1 0 0 1 1 1 1 Ribulose-phosphate 3 epimerase family QRPTase_C PF01729.19 CCF49259.1 - 0.07 12.9 0.0 0.15 11.8 0.0 1.6 1 0 0 1 1 1 0 Quinolinate phosphoribosyl transferase, C-terminal domain Mago-bind PF09282.10 CCF49261.1 - 3.3e-14 52.4 3.3 9.3e-14 51.0 3.3 1.8 1 0 0 1 1 1 1 Mago binding X PF00739.19 CCF49261.1 - 2 8.5 6.1 0.4 10.8 1.9 1.8 1 1 1 2 2 2 0 Trans-activation protein X MAPEG PF01124.18 CCF49262.1 - 4.3e-14 52.5 2.0 4.3e-14 52.5 2.0 1.9 1 1 0 2 2 2 1 MAPEG family GST_N PF02798.20 CCF49263.1 - 5.7e-18 65.0 0.0 1.1e-17 64.1 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 CCF49263.1 - 5.5e-11 42.7 0.0 1e-10 41.9 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 CCF49263.1 - 3.2e-08 33.5 0.2 5.8e-08 32.6 0.2 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 CCF49263.1 - 3.6e-08 33.5 0.0 5.3e-08 33.0 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 CCF49263.1 - 1.4e-07 31.7 0.0 2.6e-07 30.8 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 CCF49263.1 - 5.6e-07 29.7 0.1 8.6e-07 29.1 0.1 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain DUF3220 PF11516.8 CCF49263.1 - 0.085 13.1 0.0 0.13 12.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3120) CHZ PF09649.10 CCF49264.1 - 0.088 12.3 5.1 0.89 9.1 4.4 2.6 1 1 0 1 1 1 0 Histone chaperone domain CHZ COX5B PF01215.19 CCF49265.1 - 2.7e-44 150.0 0.0 3.2e-44 149.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit Vb zf-CHCC PF10276.9 CCF49265.1 - 0.00089 19.3 1.5 0.0014 18.7 1.5 1.3 1 0 0 1 1 1 1 Zinc-finger domain AMP-binding PF00501.28 CCF49266.1 - 4.9e-87 292.2 0.0 6.3e-87 291.9 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 CCF49266.1 - 3.2e-10 40.9 0.3 1.2e-09 39.0 0.3 2.1 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain AMP-binding_C_2 PF14535.6 CCF49266.1 - 0.11 12.9 0.0 0.22 11.9 0.0 1.5 1 0 0 1 1 1 0 AMP-binding enzyme C-terminal domain Zn_clus PF00172.18 CCF49267.1 - 0.076 13.1 5.3 0.16 12.1 5.3 1.5 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 CCF49269.1 - 2.1e-19 69.6 2.9 2.2e-19 69.5 0.0 2.2 3 0 0 3 3 3 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF49269.1 - 2.8e-06 27.4 6.0 4.7e-06 26.6 6.0 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Kelch_4 PF13418.6 CCF49270.1 - 1.9e-20 72.6 8.1 7.1e-06 25.9 0.0 5.8 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_3 PF13415.6 CCF49270.1 - 2.7e-10 40.3 25.6 0.0088 16.3 0.2 7.0 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_5 PF13854.6 CCF49270.1 - 1.4e-09 37.7 6.7 0.0054 16.7 0.4 6.4 7 0 0 7 7 7 2 Kelch motif Kelch_2 PF07646.15 CCF49270.1 - 0.00057 19.8 0.1 10 6.3 0.0 4.5 4 0 0 4 4 4 2 Kelch motif Kelch_6 PF13964.6 CCF49270.1 - 0.00066 19.9 15.1 0.71 10.3 0.1 5.8 6 0 0 6 6 6 2 Kelch motif Kelch_1 PF01344.25 CCF49270.1 - 0.052 13.2 0.2 3 7.5 0.0 3.2 3 0 0 3 3 3 0 Kelch motif DUF347 PF03988.12 CCF49270.1 - 0.6 10.3 3.2 4 7.7 0.1 2.8 2 0 0 2 2 2 0 Repeat of Unknown Function (DUF347) KIF1B PF12423.8 CCF49270.1 - 1.8 9.1 4.0 26 5.3 0.2 3.4 3 0 0 3 3 3 0 Kinesin protein 1B Pkinase PF00069.25 CCF49271.1 - 4.7e-46 157.3 0.0 7e-46 156.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF49271.1 - 7.2e-46 156.6 0.0 1e-45 156.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase C1_1 PF00130.22 CCF49271.1 - 4.6e-07 29.6 1.8 9.2e-07 28.7 1.8 1.5 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Haspin_kinase PF12330.8 CCF49271.1 - 0.0014 17.6 0.0 0.0026 16.8 0.0 1.3 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 CCF49271.1 - 0.0027 17.1 0.0 0.0046 16.3 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family C1_2 PF03107.16 CCF49271.1 - 0.025 14.9 0.7 0.05 13.9 0.7 1.5 1 0 0 1 1 1 0 C1 domain zf-HC5HC2H_2 PF13832.6 CCF49271.1 - 0.064 13.4 0.8 0.14 12.3 0.8 1.5 1 0 0 1 1 1 0 PHD-zinc-finger like domain Pkinase_fungal PF17667.1 CCF49271.1 - 0.091 11.5 0.0 0.16 10.7 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase APH PF01636.23 CCF49271.1 - 0.11 12.4 0.0 0.27 11.1 0.0 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family PHD PF00628.29 CCF49271.1 - 0.16 11.9 3.8 0.37 10.7 3.8 1.6 1 0 0 1 1 1 0 PHD-finger Ebp2 PF05890.12 CCF49272.1 - 2.6e-86 289.5 14.5 2.6e-86 289.5 14.5 2.0 2 0 0 2 2 2 1 Eukaryotic rRNA processing protein EBP2 CytochromB561_N PF09786.9 CCF49272.1 - 9.9 5.0 20.5 0.91 8.4 13.1 2.0 2 0 0 2 2 2 0 Cytochrome B561, N terminal LEA_5 PF00477.17 CCF49273.1 - 0.013 15.9 0.4 0.015 15.7 0.4 1.1 1 0 0 1 1 1 0 Small hydrophilic plant seed protein ABC2_membrane PF01061.24 CCF49274.1 - 3.6e-38 131.1 18.0 3.6e-38 131.1 18.0 1.9 3 0 0 3 3 3 1 ABC-2 type transporter ABC_tran PF00005.27 CCF49274.1 - 1.9e-22 80.2 0.1 3.8e-22 79.3 0.0 1.6 2 0 0 2 2 2 1 ABC transporter AAA_21 PF13304.6 CCF49274.1 - 1.7e-05 24.8 0.1 0.0073 16.1 0.0 2.2 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 CCF49274.1 - 0.02 15.3 0.1 0.037 14.4 0.1 1.5 1 0 0 1 1 1 0 AAA ATPase domain Dynamin_N PF00350.23 CCF49274.1 - 0.034 14.2 0.0 0.068 13.2 0.0 1.5 1 0 0 1 1 1 0 Dynamin family RsgA_GTPase PF03193.16 CCF49274.1 - 0.037 13.9 0.1 0.073 13.0 0.1 1.4 1 0 0 1 1 1 0 RsgA GTPase ABC2_membrane_3 PF12698.7 CCF49274.1 - 0.22 10.6 25.2 0.14 11.3 23.0 1.7 2 1 0 2 2 2 0 ABC-2 family transporter protein CPP1-like PF11833.8 CCF49274.1 - 0.27 10.9 1.1 0.93 9.1 1.1 1.9 1 0 0 1 1 1 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like RAG1_imp_bd PF12560.8 CCF49275.1 - 0.33 10.5 4.9 0.37 10.3 4.9 1.0 1 0 0 1 1 1 0 RAG1 importin binding Med15_fungi PF05397.12 CCF49276.1 - 1.5e-27 96.1 1.9 1.5e-27 96.1 1.9 4.8 6 0 0 6 6 6 1 Mediator complex subunit 15 ARID PF01388.21 CCF49276.1 - 5.1e-19 68.7 0.0 2.8e-18 66.4 0.0 2.4 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain Collagen PF01391.18 CCF49276.1 - 1.3e-06 28.1 24.2 1.3e-06 28.1 24.2 5.5 7 0 0 7 7 7 1 Collagen triple helix repeat (20 copies) DUF1970 PF09301.10 CCF49278.1 - 0.044 14.0 0.8 0.083 13.2 0.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1970) Glyco_hydro_45 PF02015.16 CCF49281.1 - 8.5e-63 212.1 7.0 1.1e-62 211.6 7.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 45 C2 PF00168.30 CCF49282.1 - 4.7e-65 216.4 0.2 5.1e-18 65.3 0.0 4.7 5 0 0 5 5 5 4 C2 domain Dexa_ind PF15198.6 CCF49282.1 - 0.13 12.3 0.0 0.45 10.7 0.0 1.9 1 0 0 1 1 1 0 Dexamethasone-induced MMM1 PF10296.9 CCF49282.1 - 0.16 11.0 0.1 0.38 9.8 0.1 1.6 1 0 0 1 1 1 0 Maintenance of mitochondrial morphology protein 1 Ubiq_cyt_C_chap PF03981.12 CCF49283.1 - 1.1e-28 100.1 2.1 9e-27 93.9 0.1 3.0 3 0 0 3 3 3 2 Ubiquinol-cytochrome C chaperone SOG2 PF10428.9 CCF49283.1 - 0.53 9.4 6.5 0.067 12.4 2.6 1.5 2 0 0 2 2 2 0 RAM signalling pathway protein PP2C PF00481.21 CCF49284.1 - 2.2e-36 125.8 0.0 4.3e-33 115.0 0.0 2.3 2 0 0 2 2 2 2 Protein phosphatase 2C WAC_Acf1_DNA_bd PF10537.9 CCF49285.1 - 3.8e-36 123.6 0.1 3.8e-36 123.6 0.1 2.7 3 0 0 3 3 3 1 ATP-utilising chromatin assembly and remodelling N-terminal WSD PF15613.6 CCF49285.1 - 6.2e-26 90.8 0.0 6.2e-26 90.8 0.0 3.2 3 0 0 3 3 3 1 Williams-Beuren syndrome DDT (WSD), D-TOX E motif DDT PF02791.17 CCF49285.1 - 4.1e-11 43.0 0.1 9.2e-11 41.9 0.1 1.6 1 0 0 1 1 1 1 DDT domain DBP10CT PF08147.12 CCF49285.1 - 0.01 16.0 2.2 0.036 14.3 2.2 2.0 1 0 0 1 1 1 0 DBP10CT (NUC160) domain LAP1C PF05609.12 CCF49285.1 - 4.9 6.1 20.7 0.11 11.6 12.2 2.2 2 0 0 2 2 2 0 Lamina-associated polypeptide 1C (LAP1C) DUF2985 PF11204.8 CCF49286.1 - 5.4e-27 93.8 1.9 1.1e-26 92.8 1.9 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2985) Molybdopterin PF00384.22 CCF49287.1 - 1.1e-75 255.3 0.0 4.7e-75 253.2 0.0 1.9 1 1 0 1 1 1 1 Molybdopterin oxidoreductase NADH_dhqG_C PF09326.11 CCF49287.1 - 2.1e-17 63.5 0.1 6.3e-17 62.0 0.1 1.9 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase subunit G, C-terminal Fer2_4 PF13510.6 CCF49287.1 - 2.7e-17 62.6 0.1 6.9e-17 61.3 0.1 1.8 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain NADH-G_4Fe-4S_3 PF10588.9 CCF49287.1 - 4.6e-17 61.3 1.8 8.1e-17 60.5 0.0 2.3 2 0 0 2 2 2 1 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region Fer2 PF00111.27 CCF49287.1 - 2.6e-08 33.7 0.5 2.6e-08 33.7 0.5 1.8 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain TPP_enzyme_M PF00205.22 CCF49287.1 - 0.018 14.8 0.2 0.52 10.0 0.1 2.5 2 0 0 2 2 2 0 Thiamine pyrophosphate enzyme, central domain Fer4 PF00037.27 CCF49287.1 - 0.29 11.0 1.8 5.9 6.9 0.6 2.5 2 0 0 2 2 2 0 4Fe-4S binding domain Aha1_N PF09229.11 CCF49288.1 - 3.5e-33 114.7 0.0 5.2e-33 114.2 0.0 1.3 1 0 0 1 1 1 1 Activator of Hsp90 ATPase, N-terminal AHSA1 PF08327.11 CCF49288.1 - 1.8e-16 60.5 0.0 1.5e-15 57.5 0.0 2.1 2 0 0 2 2 2 1 Activator of Hsp90 ATPase homolog 1-like protein Nefa_Nip30_N PF10187.9 CCF49289.1 - 1.1e-22 80.4 8.1 1.1e-22 80.4 8.1 2.3 2 0 0 2 2 2 1 N-terminal domain of NEFA-interacting nuclear protein NIP30 TAF4 PF05236.14 CCF49289.1 - 0.076 12.7 15.3 0.098 12.4 15.3 1.2 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family DUF2201_N PF13203.6 CCF49289.1 - 0.79 9.3 6.7 0.95 9.0 6.7 1.1 1 0 0 1 1 1 0 Putative metallopeptidase domain Arm PF00514.23 CCF49290.1 - 7.6e-101 327.5 7.1 4.4e-14 51.9 0.0 8.3 8 0 0 8 8 8 8 Armadillo/beta-catenin-like repeat IBB PF01749.20 CCF49290.1 - 8e-25 87.1 6.9 1.7e-24 86.1 6.9 1.5 1 0 0 1 1 1 1 Importin beta binding domain HEAT_EZ PF13513.6 CCF49290.1 - 5.5e-23 81.0 0.6 6.4e-08 32.9 0.0 6.5 4 3 3 7 7 7 6 HEAT-like repeat Arm_3 PF16186.5 CCF49290.1 - 4.3e-21 74.2 0.4 9.3e-21 73.1 0.4 1.6 1 0 0 1 1 1 1 Atypical Arm repeat HEAT_2 PF13646.6 CCF49290.1 - 1e-20 73.9 0.2 0.00068 20.0 0.0 6.1 2 1 2 6 6 5 5 HEAT repeats HEAT PF02985.22 CCF49290.1 - 4.4e-19 66.9 0.6 6.8e-05 22.8 0.0 7.2 8 0 0 8 8 8 3 HEAT repeat Adaptin_N PF01602.20 CCF49290.1 - 5.8e-07 28.4 0.0 7.1e-05 21.6 0.0 2.8 1 1 1 2 2 2 1 Adaptin N terminal region RICTOR_V PF14668.6 CCF49290.1 - 1.1e-05 25.6 0.6 0.024 14.9 0.0 4.0 3 1 1 4 4 4 1 Rapamycin-insensitive companion of mTOR, domain 5 Arm_2 PF04826.13 CCF49290.1 - 6.8e-05 22.5 0.0 0.73 9.2 0.0 3.6 2 1 2 4 4 4 2 Armadillo-like V-ATPase_H_N PF03224.14 CCF49290.1 - 0.00032 20.1 0.0 0.91 8.7 0.0 3.4 1 1 1 2 2 2 2 V-ATPase subunit H HEAT_PBS PF03130.16 CCF49290.1 - 0.00039 20.8 0.2 1.4 9.8 0.1 4.6 5 0 0 5 5 5 1 PBS lyase HEAT-like repeat V-ATPase_H_C PF11698.8 CCF49290.1 - 0.00072 19.6 0.0 0.57 10.3 0.0 3.9 3 1 2 5 5 5 2 V-ATPase subunit H Mo25 PF08569.11 CCF49290.1 - 0.00085 18.8 0.0 0.003 17.0 0.0 1.8 2 0 0 2 2 2 1 Mo25-like ABC_trans_aux PF03886.13 CCF49290.1 - 0.031 13.9 0.1 0.14 11.7 0.1 2.1 2 0 0 2 2 2 0 ABC-type transport auxiliary lipoprotein component DCB PF16213.5 CCF49290.1 - 0.09 12.4 0.0 0.59 9.8 0.0 2.1 2 0 0 2 2 2 0 Dimerisation and cyclophilin-binding domain of Mon2 GTP_cyclohydro2 PF00925.20 CCF49291.1 - 2.1e-63 212.7 0.0 4.9e-63 211.6 0.0 1.5 1 1 0 1 1 1 1 GTP cyclohydrolase II Metallophos PF00149.28 CCF49292.1 - 2e-36 126.4 0.1 3.4e-36 125.7 0.1 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 CCF49292.1 - 1.1e-17 64.2 0.0 2.1e-17 63.3 0.0 1.5 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain Band_7 PF01145.25 CCF49293.1 - 2e-28 99.6 1.8 2.8e-28 99.1 1.8 1.3 1 0 0 1 1 1 1 SPFH domain / Band 7 family Band_7_1 PF13421.6 CCF49293.1 - 0.017 14.9 0.1 0.025 14.3 0.1 1.4 1 0 0 1 1 1 0 SPFH domain-Band 7 family DUF2605 PF10792.9 CCF49293.1 - 0.032 14.1 3.0 7.6 6.5 0.5 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF2605) Ribosomal_L7Ae PF01248.26 CCF49294.1 - 2.1e-22 78.7 0.0 2.4e-22 78.5 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family FKBP_C PF00254.28 CCF49294.1 - 0.033 14.5 0.1 0.093 13.1 0.0 1.6 2 0 0 2 2 2 0 FKBP-type peptidyl-prolyl cis-trans isomerase Ribosomal_L37e PF01907.19 CCF49295.1 - 2.9e-27 94.6 10.8 2.9e-27 94.6 10.8 1.6 2 0 0 2 2 2 1 Ribosomal protein L37e SelR PF01641.18 CCF49295.1 - 0.019 15.1 0.4 0.021 14.9 0.4 1.2 1 0 0 1 1 1 0 SelR domain DZR PF12773.7 CCF49295.1 - 0.021 14.8 1.2 0.032 14.3 1.2 1.3 1 0 0 1 1 1 0 Double zinc ribbon DUF2845 PF11006.8 CCF49295.1 - 0.057 13.5 0.3 0.072 13.2 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2845) zf-RING_10 PF16685.5 CCF49295.1 - 0.076 13.2 2.1 0.1 12.8 2.1 1.2 1 0 0 1 1 1 0 zinc RING finger of MSL2 Leo1 PF04004.13 CCF49296.1 - 1.3e-50 171.5 0.1 3.6e-50 170.1 0.1 1.8 1 0 0 1 1 1 1 Leo1-like protein Mgm101p PF06420.12 CCF49297.1 - 9.3e-81 269.4 0.0 1.2e-80 269.0 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial genome maintenance MGM101 UBM PF14377.6 CCF49298.1 - 0.22 11.0 0.0 0.22 11.0 0.0 3.6 4 0 0 4 4 4 0 Ubiquitin binding region Acyl-CoA_dh_1 PF00441.24 CCF49299.1 - 1.5e-43 148.6 0.4 2.4e-43 147.9 0.4 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 CCF49299.1 - 3e-36 124.5 0.0 5.4e-36 123.7 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 CCF49299.1 - 5e-26 90.7 0.1 1.1e-25 89.7 0.1 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 CCF49299.1 - 8.5e-21 74.6 0.1 1.3e-20 74.0 0.1 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Tachystatin_B PF11478.8 CCF49299.1 - 0.26 11.3 3.2 0.53 10.3 3.2 1.4 1 0 0 1 1 1 0 Antimicrobial chitin binding protein tachystatin B Yae1_N PF09811.9 CCF49300.1 - 1.8e-11 43.5 7.9 3.4e-11 42.6 7.9 1.5 1 0 0 1 1 1 1 Essential protein Yae1, N terminal PBECR4 PF18813.1 CCF49300.1 - 0.095 12.9 0.0 0.13 12.5 0.0 1.2 1 0 0 1 1 1 0 phage-Barnase-EndoU-ColicinE5/D-RelE like nuclease4 RRM_1 PF00076.22 CCF49301.1 - 9.8e-13 47.7 0.6 1.4e-08 34.4 0.0 3.7 3 1 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Spt20 PF12090.8 CCF49301.1 - 2.2 7.9 28.1 0.35 10.4 7.6 2.4 2 0 0 2 2 2 0 Spt20 family CSN8_PSD8_EIF3K PF10075.9 CCF49303.1 - 5.4e-32 110.7 0.2 2.4e-30 105.4 0.1 2.4 1 1 0 1 1 1 1 CSN8/PSMD8/EIF3K family NUDIX PF00293.28 CCF49304.1 - 1.3e-25 89.9 0.0 1.8e-25 89.5 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain Ribosomal_L6 PF00347.23 CCF49305.1 - 2.2e-23 82.7 0.2 6.6e-12 45.9 0.0 2.3 2 0 0 2 2 2 2 Ribosomal protein L6 DUF5490 PF17593.2 CCF49305.1 - 0.11 12.5 0.0 0.22 11.6 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5490) MFS_1 PF07690.16 CCF49308.1 - 3.8e-09 35.9 22.2 5.8e-09 35.3 22.2 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily UNC-93 PF05978.16 CCF49308.1 - 4.2e-07 29.8 3.1 4.2e-07 29.8 3.1 2.1 3 0 0 3 3 3 1 Ion channel regulatory protein UNC-93 Aminotran_1_2 PF00155.21 CCF49309.1 - 2.3e-52 178.4 0.0 4.2e-52 177.5 0.0 1.4 1 1 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 CCF49309.1 - 0.0014 18.0 0.0 0.0019 17.5 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase DHHC PF01529.20 CCF49310.1 - 3.3e-29 101.7 4.5 3.3e-29 101.7 4.5 1.8 2 0 0 2 2 2 1 DHHC palmitoyltransferase zf-tcix PF14952.6 CCF49310.1 - 0.29 10.8 2.8 0.6 9.8 2.8 1.4 1 0 0 1 1 1 0 Putative treble-clef, zinc-finger, Zn-binding DUF35_N PF12172.8 CCF49310.1 - 1.2 9.1 5.5 2.8 7.9 5.5 1.5 1 0 0 1 1 1 0 Rubredoxin-like zinc ribbon domain (DUF35_N) Formyl_trans_N PF00551.19 CCF49311.1 - 1.3e-16 60.9 0.0 1.9e-16 60.3 0.0 1.3 1 0 0 1 1 1 1 Formyl transferase Formyl_trans_C PF02911.18 CCF49311.1 - 0.00075 19.7 0.1 0.002 18.3 0.1 1.8 1 1 0 1 1 1 1 Formyl transferase, C-terminal domain GGACT PF06094.12 CCF49312.1 - 1.6e-13 51.3 0.1 4.2e-13 49.9 0.1 1.8 1 1 0 1 1 1 1 Gamma-glutamyl cyclotransferase, AIG2-like Acyltransferase PF01553.21 CCF49312.1 - 1.4e-12 47.4 0.0 3.2e-12 46.2 0.0 1.6 1 0 0 1 1 1 1 Acyltransferase TetR_C_20 PF17925.1 CCF49312.1 - 0.21 11.9 2.8 0.61 10.4 0.1 2.9 3 1 0 3 3 3 0 Tetracyclin repressor-like, C-terminal domain GCIP PF13324.6 CCF49313.1 - 2.7e-09 37.0 0.2 2.7e-09 37.0 0.2 4.7 3 3 2 5 5 5 2 Grap2 and cyclin-D-interacting Aminotran_5 PF00266.19 CCF49313.1 - 1.2e-08 34.3 0.0 2.5e-08 33.3 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class-V YqzH PF14164.6 CCF49313.1 - 0.12 12.5 0.0 0.5 10.5 0.0 2.2 1 0 0 1 1 1 0 YqzH-like protein WW PF00397.26 CCF49314.1 - 0.00071 19.6 0.4 0.00071 19.6 0.4 1.9 2 0 0 2 2 2 1 WW domain rRNA_processing PF08524.11 CCF49314.1 - 0.21 11.6 7.8 0.36 10.8 7.8 1.3 1 0 0 1 1 1 0 rRNA processing CDC45 PF02724.14 CCF49314.1 - 0.25 9.6 6.3 0.32 9.2 6.3 1.0 1 0 0 1 1 1 0 CDC45-like protein FRG2 PF15315.6 CCF49314.1 - 0.56 10.4 10.0 0.97 9.6 10.0 1.3 1 0 0 1 1 1 0 Facioscapulohumeral muscular dystrophy candidate 2 Suf PF05843.14 CCF49314.1 - 4.8 7.1 6.9 6.3 6.7 6.9 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Presenilin PF01080.17 CCF49314.1 - 4.9 5.8 4.6 6 5.5 4.6 1.1 1 0 0 1 1 1 0 Presenilin tRNA-synt_2b PF00587.25 CCF49315.1 - 3.8e-36 124.7 0.0 7.3e-36 123.8 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 CCF49315.1 - 5.2e-20 71.4 0.3 1.1e-19 70.3 0.3 1.6 1 0 0 1 1 1 1 Anticodon binding domain TGS PF02824.21 CCF49315.1 - 8.2e-12 45.0 0.0 5.8e-10 39.1 0.0 2.4 2 0 0 2 2 2 1 TGS domain tRNA_SAD PF07973.14 CCF49315.1 - 5.5e-10 39.2 0.0 1.1e-09 38.2 0.0 1.6 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain DUF2722 PF10846.8 CCF49315.1 - 0.014 14.4 8.3 0.022 13.7 8.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) DUF4647 PF15504.6 CCF49315.1 - 0.045 12.9 7.8 0.072 12.2 7.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4647) DUF5444 PF17519.2 CCF49315.1 - 0.14 12.1 0.0 0.35 10.9 0.0 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5444) Spt20 PF12090.8 CCF49315.1 - 0.7 9.5 18.9 1.6 8.3 18.9 1.5 1 0 0 1 1 1 0 Spt20 family DUF4770 PF15994.5 CCF49315.1 - 1.3 9.2 8.9 2.9 8.1 8.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) Presenilin PF01080.17 CCF49315.1 - 1.3 7.7 5.9 1.8 7.2 5.9 1.2 1 0 0 1 1 1 0 Presenilin SpoIIP PF07454.11 CCF49315.1 - 7.3 6.0 10.2 3.9 6.9 7.9 1.7 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) SPX PF03105.19 CCF49316.1 - 0.34 10.8 4.9 1.4 8.8 4.9 1.8 1 1 0 1 1 1 0 SPX domain PTPA PF03095.15 CCF49317.1 - 9e-101 337.3 0.0 1.1e-100 337.0 0.0 1.1 1 0 0 1 1 1 1 Phosphotyrosyl phosphate activator (PTPA) protein Ndc1_Nup PF09531.10 CCF49318.1 - 2 7.0 8.0 2.8 6.5 8.0 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup AhpC-TSA PF00578.21 CCF49319.1 - 1.1e-23 83.5 0.0 1.5e-23 83.1 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 CCF49319.1 - 6.3e-12 45.4 0.1 1.2e-11 44.5 0.0 1.4 2 0 0 2 2 2 1 Redoxin AhpC-TSA_2 PF13911.6 CCF49319.1 - 0.12 12.5 0.0 0.17 12.0 0.0 1.3 1 0 0 1 1 1 0 AhpC/TSA antioxidant enzyme p450 PF00067.22 CCF49323.1 - 1.6e-69 234.8 0.0 2.2e-69 234.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Pkinase PF00069.25 CCF49324.1 - 1e-54 185.6 0.0 1.4e-54 185.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF49324.1 - 4.9e-42 144.0 0.0 7.4e-42 143.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CCF49324.1 - 5.3e-07 28.8 1.5 8.7e-07 28.1 0.0 1.9 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 CCF49324.1 - 0.0071 15.7 0.0 0.013 14.8 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 CCF49324.1 - 0.015 15.3 0.1 0.03 14.2 0.1 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.14 CCF49324.1 - 0.081 12.3 0.0 0.16 11.3 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family LIDHydrolase PF10230.9 CCF49325.1 - 2.8e-39 135.3 0.0 5.6e-39 134.3 0.0 1.4 2 0 0 2 2 2 1 Lipid-droplet associated hydrolase Abhydrolase_6 PF12697.7 CCF49325.1 - 2.4e-06 28.3 1.2 3.4e-06 27.8 1.2 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CCF49325.1 - 0.016 14.5 0.1 0.036 13.3 0.1 1.6 1 1 0 1 1 1 0 Serine aminopeptidase, S33 Chromo_shadow PF01393.19 CCF49326.1 - 3.5e-12 46.2 0.1 9.6e-08 32.0 0.0 2.4 2 0 0 2 2 2 2 Chromo shadow domain Chromo PF00385.24 CCF49326.1 - 4.3e-12 45.8 0.3 8.6e-12 44.8 0.3 1.6 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain WD40 PF00400.32 CCF49327.1 - 1.9e-46 155.1 20.0 4.7e-06 27.2 1.3 9.4 8 1 0 8 8 8 7 WD domain, G-beta repeat F-box PF00646.33 CCF49327.1 - 6.9e-10 38.6 0.1 1.6e-09 37.4 0.1 1.6 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 CCF49327.1 - 7.7e-10 38.5 0.0 1.5e-09 37.6 0.0 1.5 1 0 0 1 1 1 1 F-box-like Nup160 PF11715.8 CCF49327.1 - 2e-08 33.3 3.6 0.057 12.1 0.0 6.3 3 1 2 6 6 6 2 Nucleoporin Nup120/160 TFIIA PF03153.13 CCF49327.1 - 0.0078 16.3 25.7 0.0078 16.3 25.7 2.8 3 0 0 3 3 3 1 Transcription factor IIA, alpha/beta subunit Macoilin PF09726.9 CCF49327.1 - 0.0093 14.6 9.2 0.015 13.9 9.2 1.3 1 0 0 1 1 1 1 Macoilin family F-box_4 PF15966.5 CCF49327.1 - 0.013 15.3 0.0 0.013 15.3 0.0 2.3 3 0 0 3 3 2 0 F-box WD40_like PF17005.5 CCF49327.1 - 0.077 12.3 0.0 6.5 6.0 0.0 2.2 2 0 0 2 2 2 0 WD40-like domain PALB2_WD40 PF16756.5 CCF49327.1 - 0.36 9.7 6.2 58 2.5 0.1 5.1 4 2 2 6 6 6 0 Partner and localizer of BRCA2 WD40 domain FAM76 PF16046.5 CCF49327.1 - 0.53 9.6 12.7 1 8.6 12.7 1.4 1 0 0 1 1 1 0 FAM76 protein SLC12 PF03522.15 CCF49327.1 - 1.6 7.7 8.4 2.5 7.0 8.4 1.2 1 0 0 1 1 1 0 Solute carrier family 12 Otopetrin PF03189.13 CCF49327.1 - 3.3 6.4 5.8 5.1 5.8 5.8 1.2 1 0 0 1 1 1 0 Otopetrin Lin-8 PF03353.15 CCF49327.1 - 4.2 6.9 15.9 9.8 5.6 15.9 1.5 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Tim54 PF11711.8 CCF49327.1 - 6.1 5.5 9.5 10 4.8 9.5 1.3 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF4770 PF15994.5 CCF49327.1 - 8.2 6.6 11.7 2.8 8.2 8.4 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4770) Ribosomal_L26 PF16906.5 CCF49328.1 - 8.6e-38 128.7 2.2 1.1e-37 128.3 2.2 1.2 1 0 0 1 1 1 1 Ribosomal proteins L26 eukaryotic, L24P archaeal KOW PF00467.29 CCF49328.1 - 4.2e-07 29.7 0.8 7.6e-07 28.9 0.8 1.5 1 0 0 1 1 1 1 KOW motif Methyltrans_RNA PF04452.14 CCF49328.1 - 0.063 12.6 0.2 0.072 12.4 0.2 1.3 1 0 0 1 1 1 0 RNA methyltransferase Kei1 PF08552.11 CCF49329.1 - 4e-55 186.7 4.0 5.1e-55 186.3 4.0 1.1 1 0 0 1 1 1 1 Inositolphosphorylceramide synthase subunit Kei1 RVT_1 PF00078.27 CCF49331.1 - 0.00063 19.3 0.0 0.0011 18.6 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos PF03372.23 CCF49331.1 - 0.044 13.3 0.1 0.072 12.6 0.1 1.4 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family Per1 PF04080.13 CCF49333.1 - 2.8e-99 332.0 0.9 3.6e-99 331.7 0.9 1.1 1 0 0 1 1 1 1 Per1-like family Methyltrn_RNA_3 PF02598.17 CCF49334.1 - 9.6e-106 353.5 0.0 1.1e-105 353.2 0.0 1.1 1 0 0 1 1 1 1 Putative RNA methyltransferase RNase_II_C_S1 PF18614.1 CCF49334.1 - 0.067 13.1 0.9 2.9 7.9 0.1 2.6 2 0 0 2 2 2 0 RNase II-type exonuclease C-terminal S1 domain DUF5539 PF17693.1 CCF49334.1 - 0.64 9.6 6.9 1.3 8.6 6.9 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5539) Rrn6 PF10214.9 CCF49334.1 - 2 6.8 11.9 3.4 6.1 11.9 1.3 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor RRM_1 PF00076.22 CCF49335.1 - 7.7e-10 38.5 0.1 3.3e-09 36.4 0.1 2.0 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF3602 PF12223.8 CCF49335.1 - 0.26 11.9 13.1 0.17 12.5 5.3 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3602) D123 PF07065.14 CCF49336.1 - 3.5e-88 295.7 0.1 4.3e-88 295.4 0.1 1.1 1 0 0 1 1 1 1 D123 HLH PF00010.26 CCF49337.1 - 0.00014 21.8 0.2 0.00035 20.5 0.2 1.7 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Pkinase PF00069.25 CCF49338.1 - 7.7e-64 215.6 0.0 9.7e-64 215.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF49338.1 - 2.9e-34 118.5 0.0 4.3e-34 118.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCF49338.1 - 1.3e-07 31.3 0.0 2.7e-07 30.2 0.0 1.5 1 1 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 CCF49338.1 - 4.3e-05 22.5 0.0 9e-05 21.4 0.0 1.4 2 0 0 2 2 2 1 Fungal protein kinase APH PF01636.23 CCF49338.1 - 0.0012 18.9 0.0 0.21 11.5 0.0 2.3 2 0 0 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 CCF49338.1 - 0.021 14.2 0.0 0.035 13.5 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Snf7 PF03357.21 CCF49339.1 - 1.7e-41 141.7 21.0 8.8e-41 139.4 20.6 1.9 2 0 0 2 2 2 1 Snf7 DUF4407 PF14362.6 CCF49339.1 - 0.04 13.3 8.0 0.066 12.6 8.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Exonuc_VII_L PF02601.15 CCF49339.1 - 0.053 13.1 7.3 0.07 12.7 7.3 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit KfrA_N PF11740.8 CCF49339.1 - 0.065 13.9 1.9 0.065 13.9 1.9 3.1 2 1 0 2 2 2 0 Plasmid replication region DNA-binding N-term Ribosomal_L10 PF00466.20 CCF49339.1 - 0.11 12.7 3.4 0.31 11.2 0.1 2.2 2 0 0 2 2 2 0 Ribosomal protein L10 Ist1 PF03398.14 CCF49339.1 - 0.13 12.2 7.0 0.17 11.8 7.0 1.3 1 1 0 1 1 1 0 Regulator of Vps4 activity in the MVB pathway DDE_Tnp_ISL3 PF01610.17 CCF49339.1 - 0.2 11.4 5.9 0.28 10.9 5.9 1.2 1 0 0 1 1 1 0 Transposase hDGE_amylase PF14701.6 CCF49339.1 - 0.54 9.3 3.8 0.71 8.9 3.8 1.1 1 0 0 1 1 1 0 Glycogen debranching enzyme, glucanotransferase domain PspA_IM30 PF04012.12 CCF49339.1 - 0.58 9.7 22.0 0.017 14.7 7.0 2.1 1 1 1 2 2 2 0 PspA/IM30 family TPR_MLP1_2 PF07926.12 CCF49339.1 - 0.61 10.2 14.0 1.9 8.5 7.1 2.2 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein KxDL PF10241.9 CCF49339.1 - 1.7 9.0 11.1 3 8.2 1.7 3.0 2 1 0 2 2 2 0 Uncharacterized conserved protein Uds1 PF15456.6 CCF49339.1 - 3.5 7.8 13.3 0.4 10.8 0.8 2.9 2 1 0 3 3 3 0 Up-regulated During Septation COG2 PF06148.11 CCF49339.1 - 6 7.0 11.0 0.81 9.8 4.6 2.4 1 1 2 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 CLN3 PF02487.17 CCF49340.1 - 3.4e-116 388.6 0.1 1.2e-115 386.8 0.1 1.7 1 1 0 1 1 1 1 CLN3 protein CLP1_P PF16575.5 CCF49341.1 - 1.4e-25 90.2 0.0 3.3e-12 46.6 0.0 2.4 2 0 0 2 2 2 2 mRNA cleavage and polyadenylation factor CLP1 P-loop W2 PF02020.18 CCF49342.1 - 2.6e-16 59.5 0.8 8.8e-16 57.8 0.8 2.0 1 0 0 1 1 1 1 eIF4-gamma/eIF5/eIF2-epsilon Hexapep PF00132.24 CCF49342.1 - 2.6e-10 39.6 7.9 0.00084 19.0 3.7 4.0 1 1 1 3 3 3 3 Bacterial transferase hexapeptide (six repeats) NTP_transferase PF00483.23 CCF49342.1 - 1e-09 38.3 0.0 1.7e-09 37.6 0.0 1.3 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.7 CCF49342.1 - 0.00051 20.4 0.0 0.00091 19.6 0.0 1.4 1 0 0 1 1 1 1 MobA-like NTP transferase domain Fucokinase PF07959.12 CCF49342.1 - 0.12 11.3 0.3 0.21 10.5 0.3 1.3 1 0 0 1 1 1 0 L-fucokinase DUF4954 PF16314.5 CCF49342.1 - 0.13 10.4 0.8 0.2 9.8 0.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4954) RNA_pol_Rpc4 PF05132.14 CCF49343.1 - 1.5e-31 109.9 2.3 1.5e-31 109.9 2.3 4.4 4 1 0 4 4 4 1 RNA polymerase III RPC4 PGK PF00162.19 CCF49344.1 - 3.2e-148 493.7 1.2 3.6e-148 493.5 1.2 1.0 1 0 0 1 1 1 1 Phosphoglycerate kinase Arginosuc_synth PF00764.19 CCF49345.1 - 1.6e-160 534.7 0.0 1.9e-160 534.4 0.0 1.0 1 0 0 1 1 1 1 Arginosuccinate synthase QueC PF06508.13 CCF49345.1 - 0.00018 21.1 0.0 0.00029 20.4 0.0 1.3 1 0 0 1 1 1 1 Queuosine biosynthesis protein QueC tRNA_Me_trans PF03054.16 CCF49345.1 - 0.012 14.4 0.0 0.032 13.0 0.0 1.7 1 1 1 2 2 2 0 tRNA methyl transferase Iso_dh PF00180.20 CCF49347.1 - 5.6e-92 308.6 0.0 7.1e-92 308.2 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase zf-C2H2 PF00096.26 CCF49348.1 - 1.1e-10 41.4 6.4 4.8e-05 23.6 0.1 3.1 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 CCF49348.1 - 2.5e-08 34.0 2.7 1.3e-05 25.4 0.3 2.8 2 0 0 2 2 2 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 CCF49348.1 - 2.2e-07 31.1 7.5 0.0021 18.7 0.1 3.0 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 CCF49348.1 - 4.5e-06 26.8 1.5 0.086 13.1 0.7 2.8 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.6 CCF49348.1 - 0.0028 17.4 1.5 1.6 8.5 0.0 3.0 2 0 0 2 2 2 2 C2H2-type zinc-finger domain zf-BED PF02892.15 CCF49348.1 - 0.06 13.4 0.4 3.3 7.8 0.1 2.5 2 0 0 2 2 2 0 BED zinc finger zf-met PF12874.7 CCF49348.1 - 0.14 12.5 4.8 1.3 9.5 0.4 3.0 3 0 0 3 3 2 0 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 CCF49348.1 - 0.35 10.9 2.1 3.9 7.6 0.1 2.4 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_2 PF12756.7 CCF49348.1 - 0.37 11.1 1.3 4.6 7.6 0.1 2.3 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-C2HE PF16278.5 CCF49348.1 - 0.51 10.8 2.6 26 5.4 0.1 2.4 1 1 1 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_11 PF16622.5 CCF49348.1 - 0.58 10.0 4.0 4.3 7.2 0.7 2.8 3 0 0 3 3 3 0 zinc-finger C2H2-type AAA_5 PF07728.14 CCF49349.1 - 5e-119 392.6 0.0 3.2e-20 72.5 0.0 9.8 9 0 0 9 9 9 9 AAA domain (dynein-related subfamily) AAA_lid_7 PF17867.1 CCF49349.1 - 1.7e-51 172.9 3.7 5.9e-19 68.2 0.0 6.1 5 0 0 5 5 4 3 Midasin AAA lid domain AAA_lid_5 PF17865.1 CCF49349.1 - 1.5e-28 98.9 0.0 1.1e-27 96.2 0.0 2.5 3 0 0 3 3 1 1 Midasin AAA lid domain AAA PF00004.29 CCF49349.1 - 1.6e-25 90.1 0.0 0.0043 17.5 0.0 7.3 6 0 0 6 6 6 5 ATPase family associated with various cellular activities (AAA) AAA_3 PF07726.11 CCF49349.1 - 3.1e-25 88.5 0.0 3.4e-06 26.9 0.0 8.0 8 0 0 8 8 7 3 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 CCF49349.1 - 3.6e-23 82.8 28.7 0.00016 22.1 1.3 11.0 8 1 0 8 8 7 6 AAA ATPase domain Dynein_heavy PF03028.15 CCF49349.1 - 6.7e-23 81.1 0.0 4.9e-05 23.4 0.0 8.2 9 0 0 9 9 7 4 Dynein heavy chain region D6 P-loop domain AAA_22 PF13401.6 CCF49349.1 - 3.7e-21 75.8 0.1 0.0072 16.6 0.0 7.7 6 0 0 6 6 6 4 AAA domain AAA_7 PF12775.7 CCF49349.1 - 2.6e-20 72.7 0.1 0.00046 19.7 0.0 6.9 7 0 0 7 7 6 2 P-loop containing dynein motor region AAA_6 PF12774.7 CCF49349.1 - 3.2e-18 65.8 0.0 0.0067 15.4 0.1 8.0 8 0 0 8 8 8 3 Hydrolytic ATP binding site of dynein motor region AAA_18 PF13238.6 CCF49349.1 - 3.9e-18 66.2 0.1 0.11 13.0 0.0 7.3 6 0 0 6 6 6 4 AAA domain ABC_tran PF00005.27 CCF49349.1 - 5.3e-16 59.4 3.9 0.019 15.5 0.0 7.5 8 0 0 8 8 6 3 ABC transporter AAA_33 PF13671.6 CCF49349.1 - 4e-14 53.0 5.3 0.041 14.0 0.0 7.8 8 0 0 8 8 6 2 AAA domain Sigma54_activat PF00158.26 CCF49349.1 - 2.4e-13 50.2 0.0 0.079 12.7 0.0 6.1 6 0 0 6 6 5 3 Sigma-54 interaction domain TsaE PF02367.17 CCF49349.1 - 4.8e-13 49.2 5.2 0.26 11.3 0.1 6.7 6 0 0 6 6 6 3 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_28 PF13521.6 CCF49349.1 - 9.8e-13 48.7 3.6 0.12 12.6 0.0 7.5 7 0 0 7 7 6 2 AAA domain AAA_29 PF13555.6 CCF49349.1 - 1.7e-10 40.5 2.9 0.85 9.4 0.0 6.5 7 0 0 7 7 6 2 P-loop containing region of AAA domain T2SSE PF00437.20 CCF49349.1 - 4.4e-10 39.1 3.5 0.31 10.0 0.0 6.3 6 0 0 6 6 6 3 Type II/IV secretion system protein Mg_chelatase PF01078.21 CCF49349.1 - 4.7e-10 39.2 4.2 0.32 10.3 0.2 7.5 7 0 0 7 7 7 1 Magnesium chelatase, subunit ChlI AAA_14 PF13173.6 CCF49349.1 - 4.9e-10 39.6 0.0 0.0072 16.4 0.0 6.8 8 0 0 8 8 6 1 AAA domain RNA_helicase PF00910.22 CCF49349.1 - 1.1e-09 38.6 0.2 2.9 8.3 0.0 6.6 6 0 0 6 6 6 1 RNA helicase Zeta_toxin PF06414.12 CCF49349.1 - 1.2e-09 37.8 2.0 0.63 9.3 0.0 7.1 6 1 0 6 6 6 2 Zeta toxin Sigma54_activ_2 PF14532.6 CCF49349.1 - 1.2e-09 38.4 2.3 0.084 13.0 0.0 6.4 7 0 0 7 7 4 2 Sigma-54 interaction domain NACHT PF05729.12 CCF49349.1 - 3e-09 37.0 2.7 0.12 12.3 0.0 6.7 5 0 0 5 5 5 1 NACHT domain AAA_25 PF13481.6 CCF49349.1 - 7.3e-09 35.5 5.4 0.32 10.5 0.0 6.5 6 0 0 6 6 6 2 AAA domain RsgA_GTPase PF03193.16 CCF49349.1 - 1.6e-08 34.6 0.7 0.73 9.7 0.0 5.7 6 0 0 6 6 5 1 RsgA GTPase Rad17 PF03215.15 CCF49349.1 - 7.3e-08 32.6 2.1 1.3 8.9 0.0 5.7 6 0 0 6 6 5 1 Rad17 P-loop domain AAA_19 PF13245.6 CCF49349.1 - 1.4e-07 32.0 9.5 0.8 10.0 0.1 7.5 6 1 0 6 6 6 1 AAA domain IstB_IS21 PF01695.17 CCF49349.1 - 3e-07 30.3 0.2 1.7 8.4 0.0 5.6 5 0 0 5 5 5 1 IstB-like ATP binding protein AAA_21 PF13304.6 CCF49349.1 - 1.1e-06 28.8 0.1 0.0061 16.4 0.0 5.0 5 0 0 5 5 4 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_8 PF12780.7 CCF49349.1 - 5.1e-06 26.0 0.3 0.15 11.3 0.0 4.4 4 0 0 4 4 4 1 P-loop containing dynein motor region D4 AAA_24 PF13479.6 CCF49349.1 - 9.6e-06 25.4 0.2 16 5.1 0.0 5.7 6 0 0 6 6 5 0 AAA domain DUF815 PF05673.13 CCF49349.1 - 1.2e-05 24.6 0.9 3.6 6.7 0.0 5.2 6 0 0 6 6 5 0 Protein of unknown function (DUF815) SRP54 PF00448.22 CCF49349.1 - 1.3e-05 24.9 0.8 1.8 8.2 0.1 4.7 4 0 0 4 4 4 1 SRP54-type protein, GTPase domain TniB PF05621.11 CCF49349.1 - 2.4e-05 23.8 0.0 13 5.1 0.0 5.7 5 0 0 5 5 5 0 Bacterial TniB protein CPT PF07931.12 CCF49349.1 - 2.8e-05 24.0 4.5 11 5.9 0.0 7.1 8 0 0 8 8 7 0 Chloramphenicol phosphotransferase-like protein RuvB_N PF05496.12 CCF49349.1 - 2.9e-05 23.8 6.1 3 7.6 0.0 6.8 8 0 0 8 8 6 0 Holliday junction DNA helicase RuvB P-loop domain PduV-EutP PF10662.9 CCF49349.1 - 4.6e-05 23.2 0.1 6.8 6.4 0.1 5.0 5 0 0 5 5 4 0 Ethanolamine utilisation - propanediol utilisation Roc PF08477.13 CCF49349.1 - 5.9e-05 23.3 0.8 26 5.1 0.0 5.6 6 0 0 6 6 5 0 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 CCF49349.1 - 6.4e-05 23.0 2.2 3.5 7.7 0.0 6.4 6 1 0 6 6 6 0 50S ribosome-binding GTPase cobW PF02492.19 CCF49349.1 - 0.00026 20.6 4.8 19 4.8 0.1 6.0 6 1 0 6 6 6 0 CobW/HypB/UreG, nucleotide-binding domain TIP49 PF06068.13 CCF49349.1 - 0.00028 20.2 1.4 0.032 13.5 0.1 4.0 5 0 0 5 5 4 1 TIP49 P-loop domain Cytidylate_kin PF02224.18 CCF49349.1 - 0.00055 19.7 1.7 9.8 5.8 0.0 5.3 5 0 0 5 5 5 0 Cytidylate kinase IPT PF01745.16 CCF49349.1 - 0.0027 17.2 0.2 2.9 7.2 0.0 3.8 4 0 0 4 4 4 1 Isopentenyl transferase ATP_bind_1 PF03029.17 CCF49349.1 - 0.0035 17.2 4.1 40 3.9 0.0 5.7 6 0 0 6 6 6 0 Conserved hypothetical ATP binding protein NTPase_1 PF03266.15 CCF49349.1 - 0.004 17.1 2.5 6.9 6.5 0.0 4.9 6 0 0 6 6 4 0 NTPase AAA_15 PF13175.6 CCF49349.1 - 0.0073 16.1 0.0 4.1 7.0 0.0 4.2 4 0 0 4 4 4 0 AAA ATPase domain PRK PF00485.18 CCF49349.1 - 0.0092 15.7 0.1 29 4.3 0.0 4.2 4 0 0 4 4 3 0 Phosphoribulokinase / Uridine kinase family dNK PF01712.19 CCF49349.1 - 0.014 15.2 1.2 24 4.7 0.0 5.2 6 0 0 6 6 6 0 Deoxynucleoside kinase SRPRB PF09439.10 CCF49349.1 - 0.015 14.7 0.4 27 4.1 0.0 5.2 6 0 0 6 6 6 0 Signal recognition particle receptor beta subunit ResIII PF04851.15 CCF49349.1 - 0.017 15.2 0.0 20 5.1 0.0 3.9 4 0 0 4 4 3 0 Type III restriction enzyme, res subunit VWA_2 PF13519.6 CCF49349.1 - 0.067 13.8 0.4 0.59 10.8 0.0 2.9 2 0 0 2 2 1 0 von Willebrand factor type A domain ATPase_2 PF01637.18 CCF49349.1 - 0.078 12.9 0.0 15 5.4 0.0 4.1 5 0 0 5 5 4 0 ATPase domain predominantly from Archaea PhoH PF02562.16 CCF49349.1 - 0.086 12.3 0.7 27 4.1 0.0 4.0 4 0 0 4 4 4 0 PhoH-like protein CbiA PF01656.23 CCF49349.1 - 0.11 12.6 4.3 13 5.9 0.2 4.9 5 0 0 5 5 4 0 CobQ/CobB/MinD/ParA nucleotide binding domain G-alpha PF00503.20 CCF49349.1 - 0.11 11.6 0.2 27 3.8 0.0 3.8 4 0 0 4 4 3 0 G-protein alpha subunit KTI12 PF08433.10 CCF49349.1 - 0.16 11.4 0.1 1.9 7.9 0.0 3.0 2 0 0 2 2 2 0 Chromatin associated protein KTI12 Viral_helicase1 PF01443.18 CCF49349.1 - 0.19 11.4 1.5 37 3.9 0.0 4.3 5 0 0 5 5 3 0 Viral (Superfamily 1) RNA helicase Noelin-1 PF12308.8 CCF49349.1 - 2.6 8.1 4.6 9.8 6.2 0.2 3.8 3 0 0 3 3 3 0 Neurogenesis glycoprotein AAA_23 PF13476.6 CCF49349.1 - 2.8 8.4 0.0 2.8 8.4 0.0 9.5 8 1 1 9 9 6 0 AAA domain TFIIS_C PF01096.18 CCF49350.1 - 2.2e-16 59.4 5.8 3.7e-16 58.7 0.4 2.8 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) RNA_POL_M_15KD PF02150.16 CCF49350.1 - 2.1e-08 33.9 7.7 9.4e-05 22.2 0.3 3.0 2 1 0 2 2 2 2 RNA polymerases M/15 Kd subunit DZR PF12773.7 CCF49350.1 - 1.7e-05 24.7 5.6 0.025 14.6 0.1 2.9 2 1 0 2 2 2 2 Double zinc ribbon TF_Zn_Ribbon PF08271.12 CCF49350.1 - 2.4e-05 23.7 8.7 0.0059 16.1 0.5 2.6 2 1 0 2 2 2 2 TFIIB zinc-binding IBR PF01485.21 CCF49350.1 - 0.0027 17.9 3.3 1.7 8.9 1.3 2.4 2 1 0 2 2 2 2 IBR domain, a half RING-finger domain OrfB_Zn_ribbon PF07282.11 CCF49350.1 - 0.003 17.4 6.0 0.068 13.1 0.1 2.8 2 1 0 2 2 2 1 Putative transposase DNA-binding domain zinc_ribbon_2 PF13240.6 CCF49350.1 - 0.011 15.4 14.7 0.26 11.1 0.1 3.7 4 0 0 4 4 3 0 zinc-ribbon domain zf-TFIIB PF13453.6 CCF49350.1 - 0.016 14.6 0.8 0.016 14.6 0.8 2.5 2 1 0 2 2 2 0 Transcription factor zinc-finger Prok-RING_1 PF14446.6 CCF49350.1 - 0.017 15.0 7.9 0.27 11.2 0.7 3.3 3 1 0 3 3 3 0 Prokaryotic RING finger family 1 CpXC PF14353.6 CCF49350.1 - 0.018 15.1 5.9 17 5.5 2.3 4.0 3 1 0 3 3 3 0 CpXC protein TackOD1 PF18551.1 CCF49350.1 - 0.021 14.5 2.4 0.52 10.0 0.0 2.5 2 1 0 2 2 2 0 Thaumarchaeal output domain 1 zf-NADH-PPase PF09297.11 CCF49350.1 - 0.028 14.1 10.1 4.1 7.1 0.1 4.1 4 0 0 4 4 4 0 NADH pyrophosphatase zinc ribbon domain Baculo_LEF5_C PF11792.8 CCF49350.1 - 0.049 13.3 0.2 0.17 11.6 0.2 2.1 1 1 0 1 1 1 0 Baculoviridae late expression factor 5 C-terminal domain DUF35_N PF12172.8 CCF49350.1 - 0.05 13.5 8.0 9.5 6.2 0.1 4.1 4 0 0 4 4 4 0 Rubredoxin-like zinc ribbon domain (DUF35_N) zf-ribbon_3 PF13248.6 CCF49350.1 - 0.052 13.0 19.3 0.82 9.2 4.1 4.1 3 1 0 3 3 3 0 zinc-ribbon domain zinc_ribbon_4 PF13717.6 CCF49350.1 - 0.055 13.4 10.8 14 5.7 0.2 4.2 3 1 1 4 4 4 0 zinc-ribbon domain Terminase_GpA PF05876.12 CCF49350.1 - 0.067 11.7 0.4 0.3 9.6 0.3 1.9 2 0 0 2 2 2 0 Phage terminase large subunit (GpA) Zn_Tnp_IS1595 PF12760.7 CCF49350.1 - 0.092 12.7 9.8 4.9 7.2 2.6 3.3 2 2 0 2 2 2 0 Transposase zinc-ribbon domain zf-H2C2_2 PF13465.6 CCF49350.1 - 0.1 13.0 0.1 0.1 13.0 0.1 3.4 4 1 0 4 4 3 0 Zinc-finger double domain zf-LSD1 PF06943.12 CCF49350.1 - 0.11 12.4 0.5 0.11 12.4 0.5 2.1 3 0 0 3 3 1 0 LSD1 zinc finger NOB1_Zn_bind PF08772.11 CCF49350.1 - 0.12 12.5 7.6 7.2 6.8 0.0 3.6 3 1 1 4 4 4 0 Nin one binding (NOB1) Zn-ribbon like zf_C2H2_10 PF18414.1 CCF49350.1 - 0.12 11.9 5.4 1.1 8.9 0.9 3.2 3 0 0 3 3 3 0 C2H2 type zinc-finger zf-RING_7 PF02591.15 CCF49350.1 - 0.16 12.2 0.0 0.16 12.2 0.0 4.2 4 1 0 4 4 4 0 C4-type zinc ribbon domain eIF-5_eIF-2B PF01873.17 CCF49350.1 - 0.2 11.6 1.5 1.9 8.4 0.4 2.2 2 0 0 2 2 2 0 Domain found in IF2B/IF5 zf-IS66 PF13005.7 CCF49350.1 - 0.21 12.0 10.3 1.7 9.1 0.1 3.6 4 0 0 4 4 3 0 zinc-finger binding domain of transposase IS66 zinc_ribbon_5 PF13719.6 CCF49350.1 - 0.29 10.9 8.4 0.63 9.9 0.2 3.4 3 1 0 3 3 3 0 zinc-ribbon domain Nudix_N_2 PF14803.6 CCF49350.1 - 0.29 11.1 11.5 0.51 10.3 2.0 3.4 2 2 0 2 2 2 0 Nudix N-terminal Nop10p PF04135.12 CCF49350.1 - 0.31 11.1 4.7 1.2 9.2 0.1 3.2 3 1 1 4 4 3 0 Nucleolar RNA-binding protein, Nop10p family DUF1610 PF07754.11 CCF49350.1 - 0.34 10.9 0.2 0.34 10.9 0.2 3.9 4 0 0 4 4 3 0 Domain of unknown function (DUF1610) zf-ZPR1 PF03367.13 CCF49350.1 - 0.38 10.6 1.9 0.35 10.7 0.2 1.8 2 0 0 2 2 1 0 ZPR1 zinc-finger domain Zn_ribbon_recom PF13408.6 CCF49350.1 - 0.39 11.3 7.1 13 6.4 0.1 3.5 3 1 0 3 3 3 0 Recombinase zinc beta ribbon domain Zn-ribbon_8 PF09723.10 CCF49350.1 - 0.42 10.8 16.4 9.3 6.5 1.9 3.9 2 2 1 4 4 4 0 Zinc ribbon domain DUF1451 PF07295.11 CCF49350.1 - 0.47 10.5 3.4 4.7 7.2 0.1 2.9 3 0 0 3 3 3 0 Zinc-ribbon containing domain Ogr_Delta PF04606.12 CCF49350.1 - 0.54 10.3 10.3 8.4 6.5 2.1 3.6 3 1 0 3 3 3 0 Ogr/Delta-like zinc finger zf-LITAF-like PF10601.9 CCF49350.1 - 0.56 10.5 4.9 25 5.2 0.1 3.6 4 0 0 4 4 4 0 LITAF-like zinc ribbon domain zf-ISL3 PF14690.6 CCF49350.1 - 0.7 10.6 11.6 24 5.7 0.1 4.0 3 1 1 4 4 4 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 DUF3268 PF11672.8 CCF49350.1 - 0.76 10.1 3.4 2 8.8 0.4 2.3 2 1 0 2 2 2 0 zinc-finger-containing domain zf-MYND PF01753.18 CCF49350.1 - 0.81 9.8 4.3 13 6.0 0.3 2.7 2 1 0 2 2 2 0 MYND finger HalOD2 PF18547.1 CCF49350.1 - 0.93 9.4 6.7 7.9 6.5 0.0 3.8 3 1 0 3 3 3 0 Halobacterial output domain 2 zinc_ribbon_9 PF14369.6 CCF49350.1 - 1.3 9.4 7.4 29 5.0 0.1 3.6 4 0 0 4 4 3 0 zinc-ribbon A2L_zn_ribbon PF08792.10 CCF49350.1 - 1.3 8.8 12.6 1.9 8.3 0.2 4.0 4 0 0 4 4 4 0 A2L zinc ribbon domain DNA_ligase_ZBD PF03119.16 CCF49350.1 - 1.5 8.9 10.0 2 8.5 0.2 3.3 3 0 0 3 3 3 0 NAD-dependent DNA ligase C4 zinc finger domain Ribosomal_S27e PF01667.17 CCF49350.1 - 1.7 8.4 6.9 3.8 7.3 0.0 3.5 3 1 1 4 4 4 0 Ribosomal protein S27 UPF0547 PF10571.9 CCF49350.1 - 1.9 8.6 17.5 0.62 10.2 0.5 4.0 4 0 0 4 4 4 0 Uncharacterised protein family UPF0547 DNA_RNApol_7kD PF03604.13 CCF49350.1 - 2 8.2 12.9 1.6 8.5 2.2 3.7 3 1 1 4 4 4 0 DNA directed RNA polymerase, 7 kDa subunit zf-C4_Topoisom PF01396.19 CCF49350.1 - 2.1 8.2 14.2 10 6.0 1.6 3.5 2 1 1 3 3 3 0 Topoisomerase DNA binding C4 zinc finger DUF2752 PF10825.8 CCF49350.1 - 3 8.0 11.3 4.4 7.4 0.0 3.6 4 0 0 4 4 3 0 Protein of unknown function (DUF2752) YhfH PF14149.6 CCF49350.1 - 3.7 7.6 9.1 46 4.1 0.1 3.9 4 0 0 4 4 4 0 YhfH-like protein zf-C2H2 PF00096.26 CCF49350.1 - 3.9 8.1 10.4 1.3 9.6 1.3 3.3 3 0 0 3 3 3 0 Zinc finger, C2H2 type PhnA_Zn_Ribbon PF08274.12 CCF49350.1 - 4.4 7.3 10.7 5.7 7.0 0.1 3.4 3 1 0 3 3 2 0 PhnA Zinc-Ribbon DUF3797 PF12677.7 CCF49350.1 - 7.6 6.5 13.9 21 5.1 5.4 3.6 3 1 0 3 3 3 0 Domain of unknown function (DUF3797) Rad50_zn_hook PF04423.14 CCF49350.1 - 9 6.2 6.1 40 4.2 0.1 3.1 3 0 0 3 3 3 0 Rad50 zinc hook motif zf-tcix PF14952.6 CCF49350.1 - 9.3 6.0 13.2 26 4.6 0.3 4.0 4 0 0 4 4 4 0 Putative treble-clef, zinc-finger, Zn-binding ATG7_N PF16420.5 CCF49351.1 - 3.4e-89 299.5 0.0 5.1e-89 298.9 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-like modifier-activating enzyme ATG7 N-terminus ThiF PF00899.21 CCF49351.1 - 3.6e-44 150.9 0.0 5.4e-44 150.4 0.0 1.2 1 0 0 1 1 1 1 ThiF family Shikimate_DH PF01488.20 CCF49351.1 - 0.033 14.3 0.1 0.082 13.0 0.0 1.6 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase mRNA_cap_enzyme PF01331.19 CCF49352.1 - 5.6e-48 163.4 0.0 7.2e-48 163.0 0.0 1.1 1 0 0 1 1 1 1 mRNA capping enzyme, catalytic domain mRNA_cap_C PF03919.15 CCF49352.1 - 1.5e-28 99.6 0.0 2.2e-28 99.0 0.0 1.3 1 0 0 1 1 1 1 mRNA capping enzyme, C-terminal domain DNA_ligase_A_M PF01068.21 CCF49352.1 - 0.00032 20.4 0.0 0.006 16.2 0.0 2.4 1 1 0 1 1 1 1 ATP dependent DNA ligase domain DUF2076 PF09849.9 CCF49353.1 - 0.046 13.8 11.0 0.058 13.4 11.0 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) CYSTM PF12734.7 CCF49353.1 - 0.41 11.0 66.7 1.8e+04 -10.8 66.7 3.9 1 1 0 1 1 1 0 Cysteine-rich TM module stress tolerance Proteasome PF00227.26 CCF49354.1 - 1.1e-49 168.5 0.2 1.4e-49 168.2 0.2 1.1 1 0 0 1 1 1 1 Proteasome subunit Cellulase PF00150.18 CCF49355.1 - 1.4e-10 41.1 5.8 4.3e-10 39.5 5.7 1.8 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) SIR2 PF02146.17 CCF49356.1 - 1.9e-36 125.7 0.0 5.7e-33 114.3 0.0 3.2 1 1 0 1 1 1 1 Sir2 family TPP_enzyme_M PF00205.22 CCF49356.1 - 0.033 13.9 0.1 1.7 8.4 0.0 2.3 2 0 0 2 2 2 0 Thiamine pyrophosphate enzyme, central domain Alpha-L-AF_C PF06964.12 CCF49358.1 - 3.3e-28 98.9 0.0 5.4e-28 98.2 0.0 1.3 1 0 0 1 1 1 1 Alpha-L-arabinofuranosidase C-terminal domain RabGAP-TBC PF00566.18 CCF49359.1 - 1.6e-52 178.3 0.8 3.8e-52 177.0 0.0 1.8 2 0 0 2 2 2 1 Rab-GTPase-TBC domain Ndc1_Nup PF09531.10 CCF49359.1 - 2.3 6.8 9.3 1.2 7.8 6.9 1.6 1 1 1 2 2 2 0 Nucleoporin protein Ndc1-Nup PPR_1 PF12854.7 CCF49360.1 - 1.8e-13 50.0 0.6 2.5e-05 23.9 0.0 3.6 3 0 0 3 3 3 3 PPR repeat PPR_2 PF13041.6 CCF49360.1 - 1.4e-09 38.0 0.0 0.0033 17.6 0.0 4.0 4 0 0 4 4 4 2 PPR repeat family PPR PF01535.20 CCF49360.1 - 1.1e-08 34.7 0.0 0.011 15.9 0.0 4.1 4 0 0 4 4 4 2 PPR repeat PPR_3 PF13812.6 CCF49360.1 - 0.0024 17.9 0.0 0.32 11.1 0.0 3.3 3 0 0 3 3 3 1 Pentatricopeptide repeat domain ABC2_membrane PF01061.24 CCF49361.1 - 5.3e-75 251.4 70.5 1.2e-39 136.0 23.2 3.3 4 0 0 4 4 3 2 ABC-2 type transporter ABC_tran PF00005.27 CCF49361.1 - 2e-37 128.8 0.0 8e-19 68.5 0.0 2.5 2 0 0 2 2 2 2 ABC transporter PDR_CDR PF06422.12 CCF49361.1 - 5.2e-22 77.6 1.8 8.3e-20 70.5 0.0 3.3 4 0 0 4 4 2 2 CDR ABC transporter ABC_trans_N PF14510.6 CCF49361.1 - 8e-09 36.0 0.1 2.1e-08 34.7 0.1 1.7 1 0 0 1 1 1 1 ABC-transporter N-terminal AAA_33 PF13671.6 CCF49361.1 - 1.9e-06 28.1 0.3 0.11 12.6 0.0 2.9 3 0 0 3 3 3 2 AAA domain AAA_16 PF13191.6 CCF49361.1 - 3.7e-06 27.4 0.0 0.12 12.7 0.0 2.6 2 0 0 2 2 2 2 AAA ATPase domain AAA_29 PF13555.6 CCF49361.1 - 3e-05 23.7 0.3 0.019 14.7 0.1 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_21 PF13304.6 CCF49361.1 - 3.4e-05 23.8 0.0 0.097 12.5 0.0 2.4 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 CCF49361.1 - 0.00013 21.9 0.2 0.0036 17.2 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase AAA_18 PF13238.6 CCF49361.1 - 0.00017 22.1 0.2 0.35 11.4 0.0 3.8 4 0 0 4 4 4 1 AAA domain AAA_22 PF13401.6 CCF49361.1 - 0.0002 21.7 0.1 0.81 10.0 0.0 2.9 2 0 0 2 2 2 2 AAA domain AAA_25 PF13481.6 CCF49361.1 - 0.00059 19.5 0.1 0.039 13.5 0.0 2.4 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 CCF49361.1 - 0.0019 18.6 0.2 0.37 11.2 0.0 3.0 3 0 0 3 3 3 1 RNA helicase cobW PF02492.19 CCF49361.1 - 0.0027 17.3 0.2 0.36 10.4 0.1 2.4 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain ABC2_membrane_3 PF12698.7 CCF49361.1 - 0.0045 16.2 56.6 0.013 14.7 22.5 3.7 3 1 0 3 3 3 2 ABC-2 family transporter protein SMC_N PF02463.19 CCF49361.1 - 0.0045 16.4 0.0 0.061 12.7 0.0 2.6 3 1 0 3 3 2 1 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 CCF49361.1 - 0.0053 16.8 0.3 3.3 7.8 0.0 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_17 PF13207.6 CCF49361.1 - 0.0076 16.7 3.1 1.3 9.5 0.0 3.4 4 0 0 4 4 3 1 AAA domain NACHT PF05729.12 CCF49361.1 - 0.013 15.4 0.3 4.2 7.2 0.1 2.5 2 0 0 2 2 2 0 NACHT domain AAA_28 PF13521.6 CCF49361.1 - 0.013 15.7 0.1 0.23 11.7 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 CCF49361.1 - 0.023 14.4 0.7 3.8 7.2 0.1 2.4 2 0 0 2 2 2 0 AAA domain DnaB_C PF03796.15 CCF49361.1 - 0.03 13.6 0.0 0.18 11.1 0.0 2.1 2 0 0 2 2 2 0 DnaB-like helicase C terminal domain Zeta_toxin PF06414.12 CCF49361.1 - 0.056 12.7 0.3 11 5.3 0.1 2.4 2 0 0 2 2 2 0 Zeta toxin FtsK_SpoIIIE PF01580.18 CCF49361.1 - 0.075 12.4 0.2 2.8 7.2 0.1 2.5 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA PF00004.29 CCF49361.1 - 0.089 13.2 0.1 10 6.6 0.0 2.5 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_23 PF13476.6 CCF49361.1 - 0.55 10.7 3.0 0.59 10.6 0.0 2.3 2 0 0 2 2 2 0 AAA domain DUF1440 PF07274.12 CCF49361.1 - 1.1 9.5 5.8 13 6.2 0.5 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1440) Complex1_LYR PF05347.15 CCF49362.1 - 5.3e-09 36.0 4.9 5.3e-09 36.0 4.9 2.1 2 0 0 2 2 2 1 Complex 1 protein (LYR family) 2-oxogl_dehyd_N PF16078.5 CCF49362.1 - 0.095 12.3 0.0 0.2 11.3 0.0 1.6 1 0 0 1 1 1 0 2-oxoglutarate dehydrogenase N-terminus WD40 PF00400.32 CCF49363.1 - 0.061 14.2 0.1 8.7 7.4 0.0 3.1 2 0 0 2 2 2 0 WD domain, G-beta repeat His_Phos_1 PF00300.22 CCF49364.1 - 7.7e-15 55.1 0.0 1.3e-14 54.4 0.0 1.3 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) DUF3552 PF12072.8 CCF49364.1 - 0.094 12.1 5.0 0.17 11.3 5.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) Spc7 PF08317.11 CCF49364.1 - 0.12 11.3 3.9 1.1 8.1 4.0 2.0 2 0 0 2 2 2 0 Spc7 kinetochore protein Sugarporin_N PF11471.8 CCF49364.1 - 0.28 11.2 5.1 0.87 9.6 5.1 1.8 1 0 0 1 1 1 0 Maltoporin periplasmic N-terminal extension Palm_thioest PF02089.15 CCF49365.1 - 9.8e-78 261.3 0.0 1.2e-77 261.0 0.0 1.1 1 0 0 1 1 1 1 Palmitoyl protein thioesterase Lipase_2 PF01674.18 CCF49365.1 - 0.011 15.3 0.0 0.17 11.4 0.0 2.1 1 1 0 1 1 1 0 Lipase (class 2) Abhydrolase_1 PF00561.20 CCF49365.1 - 0.029 14.0 0.1 0.11 12.1 0.1 1.9 1 1 0 1 1 1 0 alpha/beta hydrolase fold Clat_adaptor_s PF01217.20 CCF49366.1 - 4.4e-17 62.3 0.0 5.4e-14 52.3 0.1 2.2 1 1 1 2 2 2 2 Clathrin adaptor complex small chain Pkinase PF00069.25 CCF49367.1 - 2.7e-73 246.6 0.0 3.8e-73 246.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF49367.1 - 9.8e-42 143.0 0.0 1.4e-41 142.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCF49367.1 - 9e-13 48.2 0.0 1.7e-12 47.2 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 CCF49367.1 - 0.0055 16.1 0.1 0.022 14.1 0.1 1.9 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 CCF49367.1 - 0.0064 15.5 0.1 0.014 14.4 0.1 1.5 1 0 0 1 1 1 1 Haspin like kinase domain Aldo_ket_red PF00248.21 CCF49368.1 - 2.5e-16 59.7 0.0 2.5e-09 36.8 0.0 3.0 2 1 0 2 2 2 2 Aldo/keto reductase family Chitin_synth_1 PF01644.17 CCF49369.1 - 4.1e-70 235.0 0.0 6.2e-70 234.4 0.0 1.3 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_1N PF08407.11 CCF49369.1 - 1e-27 95.9 0.0 1.8e-27 95.1 0.0 1.4 1 0 0 1 1 1 1 Chitin synthase N-terminal Chitin_synth_2 PF03142.15 CCF49369.1 - 3.5e-26 91.9 0.4 1.7e-19 69.8 0.0 2.2 2 0 0 2 2 2 2 Chitin synthase Glyco_trans_2_3 PF13632.6 CCF49369.1 - 6.6e-11 42.5 8.6 1.6e-09 38.0 0.1 2.4 1 1 1 2 2 2 2 Glycosyl transferase family group 2 RabGAP-TBC PF00566.18 CCF49370.1 - 7.4e-20 71.5 0.7 1.7e-15 57.3 0.5 2.2 2 0 0 2 2 2 2 Rab-GTPase-TBC domain NPA PF16469.5 CCF49370.1 - 0.19 12.3 0.1 0.56 10.8 0.1 1.7 1 1 0 1 1 1 0 Nematode polyprotein allergen ABA-1 Exo84_C PF16528.5 CCF49371.1 - 0.13 12.0 0.4 0.26 11.1 0.4 1.4 1 0 0 1 1 1 0 Exocyst component 84 C-terminal HrpB7 PF09486.10 CCF49371.1 - 0.35 11.2 10.7 0.22 11.9 5.2 2.7 2 0 0 2 2 2 0 Bacterial type III secretion protein (HrpB7) MFS_1 PF07690.16 CCF49372.1 - 5.9e-25 87.9 34.2 7.9e-25 87.5 34.2 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily NifU_N PF01592.16 CCF49374.1 - 3.6e-54 182.4 0.9 4.9e-54 181.9 0.1 1.6 2 0 0 2 2 2 1 NifU-like N terminal domain Ribosomal_L11 PF00298.19 CCF49375.1 - 1.6e-25 89.4 1.9 2.5e-25 88.8 1.9 1.3 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain Ribosomal_L11_N PF03946.14 CCF49375.1 - 1.1e-22 79.7 0.8 2.6e-22 78.4 0.8 1.7 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain NUC153 PF08159.12 CCF49376.1 - 5.3e-11 42.1 0.7 9.8e-11 41.3 0.7 1.5 1 0 0 1 1 1 1 NUC153 domain Proteasome PF00227.26 CCF49377.1 - 1.6e-58 197.4 0.0 3.6e-58 196.2 0.0 1.5 2 0 0 2 2 2 1 Proteasome subunit Proteasome_A_N PF10584.9 CCF49377.1 - 2e-09 37.0 0.0 7.5e-09 35.1 0.0 1.9 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature RabGAP-TBC PF00566.18 CCF49378.1 - 3.2e-11 43.3 0.2 9.8e-11 41.7 0.2 1.7 1 1 0 1 1 1 1 Rab-GTPase-TBC domain DUF3720 PF12517.8 CCF49378.1 - 0.038 14.9 1.1 0.038 14.9 1.1 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3720) Ras PF00071.22 CCF49379.1 - 1.5e-46 157.9 0.5 1.7e-46 157.8 0.5 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CCF49379.1 - 3.7e-16 59.4 0.0 5.3e-16 58.9 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CCF49379.1 - 1.4e-07 31.1 0.0 1.8e-07 30.8 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 CCF49379.1 - 1.9e-05 24.7 0.0 2.6e-05 24.3 0.0 1.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 CCF49379.1 - 0.00019 20.9 0.1 0.00023 20.6 0.1 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 CCF49379.1 - 0.0007 19.2 0.4 0.0043 16.6 0.2 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 CCF49379.1 - 0.0014 18.6 0.6 0.54 10.1 0.0 2.2 1 1 1 2 2 2 2 RsgA GTPase FeoB_N PF02421.18 CCF49379.1 - 0.0028 17.2 0.1 0.058 12.9 0.1 2.2 1 1 0 1 1 1 1 Ferrous iron transport protein B Rpr2 PF04032.16 CCF49380.1 - 4.5e-12 46.1 1.1 4.5e-12 46.1 1.1 1.9 2 0 0 2 2 2 1 RNAse P Rpr2/Rpp21/SNM1 subunit domain PRC2_HTH_1 PF18118.1 CCF49381.1 - 0.36 11.6 3.1 0.27 12.1 0.2 2.2 2 0 0 2 2 2 0 Polycomb repressive complex 2 tri-helical domain MAP65_ASE1 PF03999.12 CCF49381.1 - 0.49 9.0 5.1 0.9 8.2 5.1 1.4 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) Spt20 PF12090.8 CCF49381.1 - 0.95 9.0 13.6 1.9 8.0 13.6 1.4 1 0 0 1 1 1 0 Spt20 family Suf PF05843.14 CCF49381.1 - 2.2 8.2 5.5 5.7 6.8 5.5 1.8 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DivIC PF04977.15 CCF49381.1 - 3.7 7.4 6.6 6.9 6.5 6.6 1.4 1 0 0 1 1 1 0 Septum formation initiator Glyco_hydro_32C PF08244.12 CCF49382.1 - 4.3e-14 52.8 0.1 7.7e-14 52.0 0.1 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 32 C terminal Glyco_hydro_32N PF00251.20 CCF49382.1 - 6.8e-14 52.1 0.0 7.3e-06 25.8 0.0 2.6 2 1 0 2 2 2 2 Glycosyl hydrolases family 32 N-terminal domain SKN1 PF03935.15 CCF49383.1 - 2.4e-192 639.8 1.2 3.1e-192 639.4 1.2 1.0 1 0 0 1 1 1 1 Beta-glucan synthesis-associated protein (SKN1) Glyco_hydro_16 PF00722.21 CCF49383.1 - 9.1e-08 31.8 0.3 0.026 14.0 0.1 3.4 2 1 0 2 2 2 2 Glycosyl hydrolases family 16 Rot1 PF10681.9 CCF49384.1 - 2e-42 145.1 0.5 2.5e-42 144.8 0.5 1.1 1 0 0 1 1 1 1 Chaperone for protein-folding within the ER, fungal ODV-E18 PF10717.9 CCF49384.1 - 1.7 8.6 5.1 11 5.9 0.0 3.2 2 2 1 3 3 3 0 Occlusion-derived virus envelope protein ODV-E18 adh_short_C2 PF13561.6 CCF49386.1 - 1.3e-54 185.2 0.2 1.7e-54 184.9 0.2 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCF49386.1 - 8.3e-46 155.9 2.0 1.1e-45 155.5 2.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CCF49386.1 - 1.3e-16 61.0 1.0 2.7e-16 60.0 0.4 1.7 1 1 0 2 2 2 1 KR domain Epimerase PF01370.21 CCF49386.1 - 0.00073 19.1 0.3 0.0011 18.5 0.3 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family SBP_bac_5 PF00496.22 CCF49386.1 - 0.0087 15.1 0.0 0.011 14.7 0.0 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 5 Middle F420_oxidored PF03807.17 CCF49386.1 - 0.0089 16.6 0.8 3.6 8.2 0.0 2.9 3 0 0 3 3 3 1 NADP oxidoreductase coenzyme F420-dependent 3HCDH_N PF02737.18 CCF49386.1 - 0.014 15.3 0.2 2.1 8.2 0.3 2.2 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_2 PF03446.15 CCF49386.1 - 0.069 13.3 0.4 0.55 10.4 0.4 2.4 2 1 0 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase Polysacc_synt_2 PF02719.15 CCF49386.1 - 0.087 11.9 0.1 0.12 11.5 0.1 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein NmrA PF05368.13 CCF49386.1 - 0.12 11.9 0.5 0.21 11.1 0.5 1.4 1 0 0 1 1 1 0 NmrA-like family RCC1 PF00415.18 CCF49387.1 - 2.1e-22 79.5 6.5 0.00083 19.9 0.1 7.9 7 3 0 7 7 7 5 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 CCF49387.1 - 1.8e-09 37.1 17.2 0.9 9.4 0.1 7.5 8 0 0 8 8 8 5 Regulator of chromosome condensation (RCC1) repeat Actin PF00022.19 CCF49388.1 - 1.1e-116 389.8 0.0 1.7e-116 389.2 0.0 1.2 1 1 0 1 1 1 1 Actin BOP1NT PF08145.12 CCF49389.1 - 7.5e-107 357.1 4.8 1.2e-106 356.5 4.8 1.3 1 0 0 1 1 1 1 BOP1NT (NUC169) domain WD40 PF00400.32 CCF49389.1 - 2.1e-23 82.1 12.8 2.2e-07 31.4 0.3 7.3 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF49389.1 - 4.3e-08 33.4 0.2 0.11 12.8 0.0 5.6 2 2 4 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Intimin_C PF07979.11 CCF49389.1 - 1.3 9.5 3.9 0.55 10.7 1.0 1.8 2 0 0 2 2 2 0 Intimin C-type lectin domain SDA1 PF05285.12 CCF49389.1 - 2.2 7.6 28.3 5.4 6.3 28.3 1.7 1 0 0 1 1 1 0 SDA1 DUF2838 PF10998.8 CCF49390.1 - 2e-41 140.7 10.1 2e-41 140.7 10.1 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF2838) DUF4527 PF15030.6 CCF49390.1 - 0.092 12.2 0.9 0.17 11.3 0.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4527) DUF4618 PF15397.6 CCF49390.1 - 0.22 10.9 4.5 0.18 11.2 1.6 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4618) DNA_RNApol_7kD PF03604.13 CCF49391.1 - 4.7e-17 61.4 6.4 6e-17 61.0 6.4 1.1 1 0 0 1 1 1 1 DNA directed RNA polymerase, 7 kDa subunit Anti-TRAP PF15777.5 CCF49391.1 - 0.0033 17.4 0.1 0.0042 17.0 0.1 1.2 1 0 0 1 1 1 1 Tryptophan RNA-binding attenuator protein inhibitory protein zf-ISL3 PF14690.6 CCF49391.1 - 0.014 16.0 0.3 0.014 16.0 0.3 1.7 2 0 0 2 2 2 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 Zn-ribbon_8 PF09723.10 CCF49391.1 - 0.015 15.4 2.7 0.029 14.5 2.7 1.5 1 1 0 1 1 1 0 Zinc ribbon domain DZR PF12773.7 CCF49391.1 - 0.026 14.5 0.6 0.039 14.0 0.6 1.3 1 0 0 1 1 1 0 Double zinc ribbon GFA PF04828.14 CCF49391.1 - 0.06 13.7 0.9 3.6 8.0 0.1 2.1 1 1 1 2 2 2 0 Glutathione-dependent formaldehyde-activating enzyme HypA PF01155.19 CCF49391.1 - 0.071 13.1 0.2 0.08 13.0 0.2 1.1 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Zn_ribbon_recom PF13408.6 CCF49391.1 - 0.09 13.3 2.4 0.25 11.9 0.7 2.0 2 0 0 2 2 2 0 Recombinase zinc beta ribbon domain zinc_ribbon_10 PF10058.9 CCF49391.1 - 0.17 11.7 2.2 1.6 8.5 0.1 2.1 1 1 1 2 2 2 0 Predicted integral membrane zinc-ribbon metal-binding protein Adap_comp_sub PF00928.21 CCF49392.1 - 2.6e-45 154.9 0.0 3.8e-45 154.3 0.0 1.3 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 CCF49392.1 - 0.0098 15.8 0.0 0.016 15.1 0.0 1.3 1 0 0 1 1 1 1 Clathrin adaptor complex small chain DUF4677 PF15726.5 CCF49392.1 - 0.028 14.6 0.1 0.053 13.7 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4677) CENP-B_dimeris PF09026.10 CCF49392.1 - 0.26 11.7 8.5 0.52 10.7 8.5 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DNA_pol_phi PF04931.13 CCF49392.1 - 7.9 4.5 9.1 12 3.9 9.1 1.2 1 0 0 1 1 1 0 DNA polymerase phi SH3_1 PF00018.28 CCF49393.1 - 1.8e-22 78.7 0.0 2e-10 40.1 0.0 2.7 2 0 0 2 2 2 2 SH3 domain SH3_2 PF07653.17 CCF49393.1 - 1.2e-13 50.5 0.0 1.4e-09 37.5 0.0 2.5 2 0 0 2 2 2 2 Variant SH3 domain SH3_9 PF14604.6 CCF49393.1 - 6.5e-12 45.1 0.0 1.1e-05 25.1 0.0 2.6 2 0 0 2 2 2 2 Variant SH3 domain PX PF00787.24 CCF49393.1 - 5.4e-09 36.0 0.0 2e-08 34.2 0.0 2.0 2 0 0 2 2 2 1 PX domain RRM_1 PF00076.22 CCF49394.1 - 1.2e-26 92.3 0.0 1.4e-14 53.7 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 CCF49394.1 - 0.00042 20.3 0.4 0.29 11.2 0.0 2.8 2 1 0 2 2 2 2 Limkain b1 RRM_3 PF08777.11 CCF49394.1 - 0.0011 18.9 0.0 0.15 12.1 0.0 2.2 2 0 0 2 2 2 2 RNA binding motif RRM_7 PF16367.5 CCF49394.1 - 0.049 13.8 0.0 0.089 12.9 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif RRM_5 PF13893.6 CCF49394.1 - 0.14 11.8 0.0 3.6 7.2 0.0 2.1 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNA_bind PF08675.11 CCF49394.1 - 0.18 11.8 0.0 0.35 10.9 0.0 1.4 1 0 0 1 1 1 0 RNA binding domain Peptidase_C13 PF01650.18 CCF49395.1 - 3.7e-40 138.0 0.0 5e-40 137.6 0.0 1.1 1 0 0 1 1 1 1 Peptidase C13 family DUF4447 PF14590.6 CCF49395.1 - 0.07 12.9 0.0 0.18 11.6 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4447) ArgoMid PF16487.5 CCF49395.1 - 0.093 13.0 0.1 0.27 11.5 0.0 1.8 2 0 0 2 2 2 0 Mid domain of argonaute DUF3439 PF11921.8 CCF49395.1 - 6.5 6.7 12.4 16 5.5 12.4 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) P68HR PF08061.11 CCF49396.1 - 0.056 13.6 6.1 45 4.3 0.0 4.8 2 1 3 5 5 5 0 P68HR (NUC004) repeat Gal_mutarotas_3 PF18080.1 CCF49396.1 - 0.092 12.7 0.9 0.47 10.4 0.4 2.0 1 1 1 2 2 2 0 Galactose mutarotase-like fold domain DUF3818 PF12825.7 CCF49398.1 - 1.5e-65 221.4 0.0 2.4e-65 220.8 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function in PX-proteins (DUF3818) PXB PF12828.7 CCF49398.1 - 0.00041 20.3 0.2 0.0012 18.8 0.2 1.7 1 1 0 1 1 1 1 PX-associated DUF4692 PF15763.5 CCF49399.1 - 1.4 9.3 6.2 0.31 11.5 0.3 2.2 2 0 0 2 2 2 0 Regulator of human erythroid cell expansion (RHEX) DUF3446 PF11928.8 CCF49399.1 - 2.8 8.3 12.0 2.3 8.6 4.1 2.8 2 0 0 2 2 2 0 Early growth response N-terminal domain Glyco_hydro_cc PF11790.8 CCF49400.1 - 6.6e-56 189.5 10.2 9.2e-56 189.1 10.2 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase catalytic core Macoilin PF09726.9 CCF49400.1 - 0.0012 17.5 15.3 0.0014 17.2 15.3 1.2 1 0 0 1 1 1 1 Macoilin family SPX PF03105.19 CCF49400.1 - 0.012 15.5 10.7 0.016 15.2 10.7 1.2 1 0 0 1 1 1 0 SPX domain Apt1 PF10351.9 CCF49400.1 - 0.019 13.8 11.7 0.023 13.6 11.7 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain DUF4897 PF16238.5 CCF49400.1 - 0.066 13.0 0.0 0.13 12.1 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4897) Zip PF02535.22 CCF49400.1 - 0.08 12.2 3.9 0.094 11.9 3.9 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter NPR3 PF03666.13 CCF49400.1 - 0.2 10.4 7.9 0.27 10.0 7.9 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Miga PF10265.9 CCF49400.1 - 0.4 9.6 12.5 0.66 8.9 12.5 1.3 1 0 0 1 1 1 0 Mitoguardin Presenilin PF01080.17 CCF49400.1 - 0.76 8.5 10.8 1.3 7.8 10.8 1.2 1 0 0 1 1 1 0 Presenilin Striatin PF08232.12 CCF49400.1 - 0.92 10.1 5.6 2 9.0 5.6 1.5 1 0 0 1 1 1 0 Striatin family RAP1 PF07218.11 CCF49400.1 - 8.9 4.5 20.2 12 4.0 20.2 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Band_3_cyto PF07565.13 CCF49400.1 - 9.1 6.0 10.4 14 5.3 10.4 1.3 1 0 0 1 1 1 0 Band 3 cytoplasmic domain DAO PF01266.24 CCF49401.1 - 6e-23 82.0 0.0 1.3e-15 57.9 0.1 2.1 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CCF49401.1 - 0.0018 17.6 0.1 0.017 14.4 0.0 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CCF49401.1 - 0.0024 18.4 0.0 0.0069 16.9 0.0 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 CCF49401.1 - 0.0027 16.9 0.0 0.0038 16.4 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 CCF49401.1 - 0.003 17.8 0.1 0.0066 16.7 0.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 CCF49401.1 - 0.01 15.1 0.5 0.042 13.1 0.0 1.9 2 0 0 2 2 2 0 Thi4 family NAD_binding_7 PF13241.6 CCF49401.1 - 0.024 15.1 0.0 0.12 12.9 0.0 2.1 3 0 0 3 3 3 0 Putative NAD(P)-binding ApbA PF02558.16 CCF49401.1 - 0.028 14.1 0.0 0.047 13.3 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Glu_dehyd_C PF16912.5 CCF49401.1 - 0.08 12.4 0.0 0.73 9.3 0.0 2.0 2 0 0 2 2 2 0 Glucose dehydrogenase C-terminus 2OG-FeII_Oxy PF03171.20 CCF49402.1 - 1.7e-24 86.2 0.0 2.9e-24 85.5 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.6 CCF49402.1 - 5.3e-18 65.9 0.0 8.9e-18 65.2 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal FeoB_associated PF12669.7 CCF49404.1 - 0.088 13.2 0.4 0.16 12.4 0.4 1.4 1 0 0 1 1 1 0 FeoB-associated Cys-rich membrane protein OppC_N PF12911.7 CCF49404.1 - 0.16 11.9 0.1 0.35 10.9 0.1 1.5 1 0 0 1 1 1 0 N-terminal TM domain of oligopeptide transport permease C DUF3318 PF11780.8 CCF49404.1 - 0.28 11.1 1.1 0.55 10.2 1.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3318) DUF262 PF03235.14 CCF49405.1 - 7.5e-15 55.7 0.0 1.6e-14 54.6 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function DUF262 DUF1748 PF08520.10 CCF49406.1 - 6.6e-27 93.2 0.0 7.3e-27 93.1 0.0 1.0 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1748) Pkinase PF00069.25 CCF49407.1 - 4.7e-73 245.8 0.0 6.1e-73 245.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF49407.1 - 3.3e-30 105.3 0.0 1.6e-22 80.1 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 CCF49407.1 - 6.1e-11 42.2 0.2 0.011 15.0 0.0 3.1 3 0 0 3 3 3 3 Kinase-like Pkinase_fungal PF17667.1 CCF49407.1 - 0.0022 16.8 0.0 0.0041 15.9 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 CCF49407.1 - 0.057 12.8 0.0 0.096 12.0 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CCF49407.1 - 0.2 11.6 0.0 1.3 8.9 0.0 2.0 1 1 1 2 2 2 0 Phosphotransferase enzyme family Sedlin_N PF04628.13 CCF49408.1 - 6.1e-30 104.0 0.0 6.3e-27 94.3 0.0 2.1 2 0 0 2 2 2 2 Sedlin, N-terminal conserved region Sybindin PF04099.12 CCF49408.1 - 5.2e-05 23.2 0.0 8.3e-05 22.5 0.0 1.4 1 0 0 1 1 1 1 Sybindin-like family DUF508 PF04370.12 CCF49408.1 - 0.12 12.1 0.0 0.12 12.1 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF508) TSP9 PF11493.8 CCF49408.1 - 0.67 10.7 6.2 1.4 9.7 0.0 2.3 2 0 0 2 2 2 0 Thylakoid soluble phosphoprotein TSP9 bZIP_1 PF00170.21 CCF49409.1 - 3.4e-10 39.9 6.5 5.6e-10 39.2 6.5 1.3 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 CCF49409.1 - 0.00015 21.8 8.1 0.00028 20.9 8.1 1.5 1 0 0 1 1 1 1 Basic region leucine zipper DNA_Packaging_2 PF11123.8 CCF49409.1 - 0.01 16.0 0.1 0.019 15.1 0.1 1.4 1 0 0 1 1 1 0 DNA packaging protein bZIP_Maf PF03131.17 CCF49409.1 - 0.024 15.2 9.3 0.044 14.3 9.3 1.5 1 0 0 1 1 1 0 bZIP Maf transcription factor FlaC_arch PF05377.11 CCF49409.1 - 0.057 13.8 0.0 0.11 12.9 0.0 1.4 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) KASH_CCD PF14662.6 CCF49409.1 - 0.22 11.3 7.1 0.33 10.8 6.6 1.5 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 or KASH GTP_EFTU PF00009.27 CCF49410.1 - 3.6e-44 150.6 0.0 5.8e-44 150.0 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 CCF49410.1 - 1.1e-34 119.1 0.5 5.2e-34 116.9 0.0 2.4 3 0 0 3 3 3 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 CCF49410.1 - 2.8e-09 37.2 0.6 7e-09 36.0 0.6 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 CCF49410.1 - 0.0037 17.3 0.1 0.017 15.2 0.1 2.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase PAM2 PF07145.15 CCF49410.1 - 1.8 8.4 10.5 0.59 9.9 0.1 3.5 4 0 0 4 4 4 0 Ataxin-2 C-terminal region DAD PF02109.16 CCF49411.1 - 3.1e-47 159.4 1.2 3.9e-47 159.1 1.2 1.1 1 0 0 1 1 1 1 DAD family Rho_GDI PF02115.17 CCF49412.1 - 1.7e-68 230.2 0.0 2.1e-68 230.0 0.0 1.0 1 0 0 1 1 1 1 RHO protein GDP dissociation inhibitor E1_DerP2_DerF2 PF02221.15 CCF49412.1 - 0.14 12.6 0.0 1 9.8 0.0 2.1 1 1 0 1 1 1 0 ML domain DUF1640 PF07798.11 CCF49413.1 - 2.9e-61 206.5 3.8 5.1e-61 205.8 3.8 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1640) UbiA PF01040.18 CCF49413.1 - 3.1e-54 184.0 23.3 5.8e-54 183.0 23.3 1.4 1 0 0 1 1 1 1 UbiA prenyltransferase family TauD PF02668.16 CCF49413.1 - 3.2e-49 168.1 0.3 7.6e-49 166.9 0.3 1.6 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family DUF971 PF06155.12 CCF49413.1 - 0.0083 16.8 0.0 0.024 15.3 0.0 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF971) Cu_amine_oxidN1 PF07833.11 CCF49413.1 - 0.05 14.1 0.1 0.05 14.1 0.1 1.8 2 0 0 2 2 2 0 Copper amine oxidase N-terminal domain DUF4404 PF14357.6 CCF49413.1 - 4.4 8.0 6.6 17 6.1 6.6 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4404) PHD20L1_u1 PF16660.5 CCF49414.1 - 0.16 12.8 5.8 0.32 11.8 5.8 1.6 1 0 0 1 1 1 0 PHD finger protein 20-like protein 1 Pyr_redox_2 PF07992.14 CCF49417.1 - 3.3e-26 92.2 0.0 2.6e-21 76.1 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CCF49417.1 - 1.1e-08 35.5 0.1 0.00044 20.8 0.0 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 CCF49417.1 - 8.5e-05 21.8 0.0 0.00019 20.7 0.0 1.5 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) DAO PF01266.24 CCF49417.1 - 0.00078 19.1 0.1 0.1 12.2 0.0 2.6 3 0 0 3 3 3 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 CCF49417.1 - 0.0029 17.6 1.7 3.9 7.4 0.0 4.0 3 1 0 4 4 4 1 FAD-NAD(P)-binding Trp_halogenase PF04820.14 CCF49417.1 - 0.0034 16.3 1.2 8.7 5.1 0.2 3.1 2 1 1 3 3 3 3 Tryptophan halogenase NAD_binding_7 PF13241.6 CCF49417.1 - 0.0077 16.6 0.0 1.1 9.7 0.0 2.5 2 0 0 2 2 2 1 Putative NAD(P)-binding Pyr_redox_3 PF13738.6 CCF49417.1 - 0.024 13.9 0.0 0.053 12.8 0.0 1.6 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase TrkA_N PF02254.18 CCF49417.1 - 0.064 13.5 0.0 8.3 6.7 0.0 2.5 2 0 0 2 2 2 0 TrkA-N domain SRPRB PF09439.10 CCF49418.1 - 3e-12 46.3 0.0 8.6e-12 44.8 0.0 1.8 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 CCF49418.1 - 6.7e-06 26.2 0.0 1.3e-05 25.3 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 CCF49418.1 - 2.3e-05 24.0 0.0 0.046 13.2 0.0 2.4 1 1 1 2 2 2 2 Elongation factor Tu GTP binding domain Arf PF00025.21 CCF49418.1 - 4.8e-05 22.9 0.0 8.5e-05 22.1 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 CCF49418.1 - 0.0056 16.9 0.0 0.0095 16.1 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase FeoB_N PF02421.18 CCF49418.1 - 0.055 13.0 0.0 0.39 10.2 0.0 2.0 1 1 0 1 1 1 0 Ferrous iron transport protein B Proteasome PF00227.26 CCF49419.1 - 1.3e-46 158.5 0.0 1.7e-46 158.1 0.0 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 CCF49419.1 - 5.9e-13 48.2 0.1 1.2e-12 47.2 0.1 1.6 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature DUF883 PF05957.13 CCF49420.1 - 5.9e-05 23.6 32.4 0.061 13.9 6.5 3.5 1 1 1 3 3 3 3 Bacterial protein of unknown function (DUF883) Apolipoprotein PF01442.18 CCF49420.1 - 0.19 11.6 25.9 0.65 9.9 25.9 1.7 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain YtxH PF12732.7 CCF49420.1 - 0.31 11.6 42.7 0.21 12.1 8.2 4.2 1 1 3 4 4 4 0 YtxH-like protein Fzo_mitofusin PF04799.13 CCF49420.1 - 1.2 8.7 4.1 0.27 10.8 0.4 1.9 2 1 0 2 2 2 0 fzo-like conserved region SART-1 PF03343.13 CCF49421.1 - 1e-169 566.1 61.1 1.2e-169 565.9 61.1 1.1 1 0 0 1 1 1 1 SART-1 family PQ-loop PF04193.14 CCF49422.1 - 6.7e-35 118.7 4.4 2.4e-18 65.6 1.7 2.5 2 0 0 2 2 2 2 PQ loop repeat DUF2279 PF10043.9 CCF49422.1 - 0.0012 19.6 0.3 1.3 9.9 0.0 2.4 2 1 0 2 2 2 2 Predicted periplasmic lipoprotein (DUF2279) Form-deh_trans PF09163.11 CCF49422.1 - 0.04 13.7 0.0 0.04 13.7 0.0 1.9 2 0 0 2 2 2 0 Formate dehydrogenase N, transmembrane UPF0113_N PF17833.1 CCF49423.1 - 1.6e-30 105.5 0.0 2.4e-30 104.9 0.0 1.3 1 0 0 1 1 1 1 UPF0113 Pre-PUA domain UPF0113 PF03657.13 CCF49423.1 - 2e-24 85.6 0.0 3e-24 85.1 0.0 1.3 1 0 0 1 1 1 1 UPF0113 PUA domain PP1 PF07430.11 CCF49423.1 - 0.016 15.2 0.0 0.03 14.4 0.0 1.4 1 0 0 1 1 1 0 Phloem filament protein PP1 cystatin-like domain Utp14 PF04615.13 CCF49424.1 - 1e-200 669.1 50.4 1e-200 669.1 50.4 2.7 1 1 1 2 2 2 1 Utp14 protein Gp_dh_C PF02800.20 CCF49424.1 - 0.11 12.1 1.8 0.27 10.8 1.8 1.6 1 0 0 1 1 1 0 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain RhoGAP PF00620.27 CCF49425.1 - 5.7e-26 91.2 0.0 1e-25 90.3 0.0 1.4 1 0 0 1 1 1 1 RhoGAP domain Peptidase_M23 PF01551.22 CCF49426.1 - 0.01 16.0 0.0 0.021 15.0 0.0 1.5 1 0 0 1 1 1 0 Peptidase family M23 DUF1523 PF07509.11 CCF49426.1 - 0.046 13.1 0.0 0.086 12.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1523) Y_phosphatase PF00102.27 CCF49427.1 - 1.8e-35 122.6 0.0 4.2e-35 121.4 0.0 1.6 1 1 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 CCF49427.1 - 6.3e-05 22.8 0.0 0.00015 21.5 0.0 1.6 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain DSBA PF01323.20 CCF49428.1 - 7.3e-26 91.1 0.0 8.4e-26 90.9 0.0 1.0 1 0 0 1 1 1 1 DSBA-like thioredoxin domain HpcH_HpaI PF03328.14 CCF49429.1 - 9.8e-41 139.3 0.0 1.4e-40 138.8 0.0 1.2 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family C-C_Bond_Lyase PF15617.6 CCF49429.1 - 4e-11 42.7 0.0 2.1e-05 23.8 0.0 2.1 2 0 0 2 2 2 2 C-C_Bond_Lyase of the TIM-Barrel fold DAAD PF18752.1 CCF49429.1 - 0.046 13.6 0.1 0.065 13.1 0.1 1.1 1 0 0 1 1 1 0 Dictyosteliid AID/APOBEC-like Deaminase Aminotran_1_2 PF00155.21 CCF49430.1 - 1.9e-44 152.3 0.0 2.8e-44 151.8 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II PQ-loop PF04193.14 CCF49431.1 - 8.3e-21 73.5 9.8 5.8e-15 54.8 0.6 2.8 3 0 0 3 3 3 2 PQ loop repeat ER_lumen_recept PF00810.18 CCF49431.1 - 0.001 19.9 1.6 0.009 16.8 0.4 2.4 2 0 0 2 2 2 1 ER lumen protein retaining receptor Selenoprotein_S PF06936.11 CCF49431.1 - 0.048 13.5 2.4 0.082 12.7 2.4 1.3 1 0 0 1 1 1 0 Selenoprotein S (SelS) Endonuclease_NS PF01223.23 CCF49432.1 - 7.8e-53 179.6 0.0 4.8e-52 177.0 0.0 1.9 1 1 0 1 1 1 1 DNA/RNA non-specific endonuclease E1_dh PF00676.20 CCF49433.1 - 3.8e-89 298.6 0.0 4.8e-89 298.3 0.0 1.1 1 0 0 1 1 1 1 Dehydrogenase E1 component DXP_synthase_N PF13292.6 CCF49433.1 - 0.023 13.9 0.0 0.06 12.5 0.0 1.6 2 0 0 2 2 2 0 1-deoxy-D-xylulose-5-phosphate synthase Aminotran_3 PF00202.21 CCF49436.1 - 7.9e-92 308.0 0.0 1.3e-91 307.3 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.21 CCF49436.1 - 0.047 12.8 0.0 0.086 12.0 0.0 1.4 1 0 0 1 1 1 0 Aminotransferase class I and II GFO_IDH_MocA PF01408.22 CCF49437.1 - 3.2e-19 69.9 0.1 4.8e-19 69.4 0.1 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold Pex19 PF04614.12 CCF49438.1 - 2.9e-66 223.7 1.6 2.9e-66 223.7 1.6 2.0 2 0 0 2 2 2 1 Pex19 protein family T4SS PF07996.11 CCF49438.1 - 0.008 16.6 4.5 2.1 8.7 0.7 2.7 2 1 1 3 3 3 2 Type IV secretion system proteins DUF2884 PF11101.8 CCF49438.1 - 0.14 11.6 0.5 0.38 10.2 0.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2884) Pup PF05639.11 CCF49438.1 - 0.21 12.5 4.8 0.33 11.9 0.3 2.9 2 0 0 2 2 2 0 Pup-like protein SPX PF03105.19 CCF49438.1 - 3.3 7.5 7.9 13 5.5 8.5 1.7 2 0 0 2 2 2 0 SPX domain RasGAP PF00616.19 CCF49439.1 - 2.4e-48 164.6 0.1 1.4e-47 162.1 0.0 2.2 2 0 0 2 2 2 1 GTPase-activator protein for Ras-like GTPase RasGAP_C PF03836.15 CCF49439.1 - 2.4e-44 150.8 6.8 7.8e-44 149.1 6.8 2.0 1 0 0 1 1 1 1 RasGAP C-terminus IQ PF00612.27 CCF49439.1 - 1.4e-23 80.4 39.7 0.032 14.0 0.0 12.0 11 0 0 11 11 11 10 IQ calmodulin-binding motif CH PF00307.31 CCF49439.1 - 7e-16 58.4 0.0 2.3e-15 56.7 0.0 2.0 2 0 0 2 2 2 1 Calponin homology (CH) domain p450 PF00067.22 CCF49442.1 - 1.3e-71 241.8 0.0 1.1e-70 238.7 0.0 1.9 1 1 0 1 1 1 1 Cytochrome P450 Endosulfine PF04667.17 CCF49443.1 - 4.1e-26 90.9 0.2 7.1e-26 90.2 0.2 1.4 1 0 0 1 1 1 1 cAMP-regulated phosphoprotein/endosulfine conserved region Porin_3 PF01459.22 CCF49444.1 - 1.2e-75 254.4 0.6 1.4e-75 254.3 0.6 1.0 1 0 0 1 1 1 1 Eukaryotic porin Peptidase_C27 PF05407.12 CCF49444.1 - 0.064 13.3 0.4 0.12 12.5 0.4 1.3 1 0 0 1 1 1 0 Rubella virus endopeptidase Zn_clus PF00172.18 CCF49446.1 - 0.0002 21.4 8.5 0.00039 20.5 8.5 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PAS PF00989.25 CCF49446.1 - 0.033 14.2 0.0 0.081 12.9 0.0 1.7 1 0 0 1 1 1 0 PAS fold MLTR_LBD PF17765.1 CCF49446.1 - 0.15 12.2 0.0 1.1 9.3 0.0 2.1 1 1 1 2 2 2 0 MmyB-like transcription regulator ligand binding domain RIBIOP_C PF04950.12 CCF49447.1 - 6.8e-92 308.0 0.0 6.8e-92 308.0 0.0 2.0 2 0 0 2 2 1 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal AARP2CN PF08142.12 CCF49447.1 - 1.8e-31 108.0 0.4 4.5e-31 106.8 0.0 2.0 2 0 0 2 2 1 1 AARP2CN (NUC121) domain AAA_16 PF13191.6 CCF49447.1 - 1.2e-05 25.8 0.2 0.00045 20.6 0.0 2.9 2 0 0 2 2 2 1 AAA ATPase domain GTP_EFTU PF00009.27 CCF49447.1 - 6.2e-05 22.6 0.0 0.0039 16.8 0.0 2.6 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain AAA_22 PF13401.6 CCF49447.1 - 6.9e-05 23.1 0.0 0.00017 21.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 CCF49447.1 - 0.0014 19.1 0.0 0.0036 17.7 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) PduV-EutP PF10662.9 CCF49447.1 - 0.0016 18.2 0.1 0.0051 16.6 0.1 1.8 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation AAA_33 PF13671.6 CCF49447.1 - 0.0023 18.1 0.8 0.0095 16.1 0.0 2.6 2 1 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 CCF49447.1 - 0.0065 16.5 0.1 0.029 14.4 0.1 2.1 1 1 0 1 1 1 1 50S ribosome-binding GTPase ABC_tran PF00005.27 CCF49447.1 - 0.0074 16.8 1.8 0.021 15.3 0.0 2.6 2 0 0 2 2 2 1 ABC transporter AAA_28 PF13521.6 CCF49447.1 - 0.016 15.5 0.2 0.063 13.5 0.2 2.1 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 CCF49447.1 - 0.02 14.8 0.2 0.24 11.3 0.0 2.4 1 1 0 2 2 2 0 RsgA GTPase ATPase_2 PF01637.18 CCF49447.1 - 0.021 14.8 1.0 0.049 13.5 0.0 2.0 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea RNA_helicase PF00910.22 CCF49447.1 - 0.025 15.0 0.0 0.064 13.7 0.0 1.7 1 0 0 1 1 1 0 RNA helicase NB-ARC PF00931.22 CCF49447.1 - 0.025 13.8 0.0 0.053 12.7 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain NACHT PF05729.12 CCF49447.1 - 0.044 13.7 0.0 0.095 12.6 0.0 1.5 1 0 0 1 1 1 0 NACHT domain cobW PF02492.19 CCF49447.1 - 0.059 13.0 0.1 0.14 11.8 0.1 1.6 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain Roc PF08477.13 CCF49447.1 - 0.084 13.1 0.0 0.3 11.3 0.0 2.0 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_14 PF13173.6 CCF49447.1 - 0.11 12.6 0.1 0.32 11.0 0.1 1.8 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 CCF49447.1 - 0.11 12.0 0.0 0.26 10.8 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_18 PF13238.6 CCF49447.1 - 0.23 12.0 0.1 0.23 12.0 0.1 3.0 3 0 0 3 3 2 0 AAA domain AAA_23 PF13476.6 CCF49447.1 - 4.2 7.8 11.4 10 6.6 0.0 3.5 3 0 0 3 3 3 0 AAA domain HLH PF00010.26 CCF49448.1 - 2.6e-18 65.7 0.8 5.9e-18 64.6 0.8 1.7 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain CDC45 PF02724.14 CCF49448.1 - 0.00027 19.4 5.1 0.00027 19.4 5.1 2.7 3 0 0 3 3 3 1 CDC45-like protein NIF PF03031.18 CCF49449.1 - 2.1e-54 183.5 0.1 3e-54 183.0 0.1 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase Tcp11 PF05794.13 CCF49450.1 - 7e-99 331.9 0.0 1.2e-98 331.1 0.0 1.3 1 0 0 1 1 1 1 T-complex protein 11 IL32 PF15225.6 CCF49450.1 - 0.17 12.3 0.9 7.9 6.9 0.1 2.7 2 0 0 2 2 2 0 Interleukin 32 Cupin_8 PF13621.6 CCF49451.1 - 1.4e-22 80.7 0.0 2.1e-22 80.1 0.0 1.3 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.12 CCF49451.1 - 1.6e-07 31.1 0.0 3.4e-06 26.8 0.0 2.4 2 0 0 2 2 2 1 Cupin superfamily protein JmjC PF02373.22 CCF49451.1 - 0.0091 16.4 0.1 0.069 13.6 0.0 2.4 2 1 0 2 2 2 1 JmjC domain, hydroxylase Cupin_2 PF07883.11 CCF49451.1 - 0.059 13.1 0.0 0.18 11.6 0.0 1.7 2 0 0 2 2 2 0 Cupin domain AraC_binding PF02311.19 CCF49451.1 - 0.12 12.3 0.5 1.7 8.5 0.0 2.5 3 0 0 3 3 3 0 AraC-like ligand binding domain zf-CCHC PF00098.23 CCF49452.1 - 0.003 17.6 0.9 0.003 17.6 0.9 2.1 2 0 0 2 2 2 1 Zinc knuckle VID27_N PF17748.1 CCF49452.1 - 0.076 12.9 0.1 0.092 12.6 0.1 1.1 1 0 0 1 1 1 0 VID27 N-terminal region PEMT PF04191.13 CCF49453.1 - 9.6e-34 116.0 3.6 9.6e-34 116.0 3.6 2.1 2 1 0 2 2 2 1 Phospholipid methyltransferase Hpt PF01627.23 CCF49454.1 - 6e-08 32.8 0.1 6e-08 32.8 0.1 2.0 1 1 1 2 2 2 1 Hpt domain Uds1 PF15456.6 CCF49454.1 - 0.04 14.1 7.8 0.09 12.9 7.8 1.5 1 0 0 1 1 1 0 Up-regulated During Septation Paf1 PF03985.13 CCF49454.1 - 0.056 12.4 15.1 0.1 11.6 15.1 1.4 1 0 0 1 1 1 0 Paf1 RR_TM4-6 PF06459.12 CCF49454.1 - 0.12 12.1 17.6 0.11 12.3 16.7 1.4 1 1 0 1 1 1 0 Ryanodine Receptor TM 4-6 Arrestin_C PF02752.22 CCF49455.1 - 2e-11 44.5 3.5 8.8e-10 39.1 2.4 2.7 2 0 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 CCF49455.1 - 8.8e-08 32.3 1.0 0.0015 18.6 0.7 2.6 2 0 0 2 2 2 2 Arrestin (or S-antigen), N-terminal domain LDB19 PF13002.7 CCF49455.1 - 0.13 12.0 0.1 2.1 8.0 0.0 2.3 2 0 0 2 2 2 0 Arrestin_N terminal like DDHD PF02862.17 CCF49456.1 - 9.4e-37 127.3 0.0 9.4e-37 127.3 0.0 3.7 4 0 0 4 4 4 1 DDHD domain Ser_hydrolase PF06821.13 CCF49456.1 - 0.094 12.6 0.4 0.46 10.3 0.0 2.2 2 0 0 2 2 2 0 Serine hydrolase Csm1_N PF18504.1 CCF49456.1 - 1.2 9.6 7.4 2.6 8.5 0.0 2.9 2 0 0 2 2 2 0 Csm1 N-terminal domain Peptidase_M24 PF00557.24 CCF49457.1 - 3.1e-19 69.5 0.2 6.6e-19 68.4 0.2 1.5 1 1 0 1 1 1 1 Metallopeptidase family M24 SH3_2 PF07653.17 CCF49457.1 - 0.054 13.2 0.0 0.11 12.2 0.0 1.5 1 0 0 1 1 1 0 Variant SH3 domain Nipped-B_C PF12830.7 CCF49458.1 - 6.5e-47 159.9 0.8 2.1e-46 158.3 0.8 2.0 1 0 0 1 1 1 1 Sister chromatid cohesion C-terminus Cnd1 PF12717.7 CCF49458.1 - 5e-05 23.4 0.8 0.00037 20.6 0.3 2.6 1 1 1 2 2 2 1 non-SMC mitotic condensation complex subunit 1 Cohesin_HEAT PF12765.7 CCF49458.1 - 0.00012 22.3 6.2 0.00052 20.3 1.6 3.9 3 0 0 3 3 3 1 HEAT repeat associated with sister chromatid cohesion HEAT PF02985.22 CCF49458.1 - 0.0013 18.8 0.4 10 6.7 0.0 4.1 3 0 0 3 3 3 2 HEAT repeat VAPB_antitox PF02697.14 CCF49458.1 - 0.95 10.3 4.2 1.1 10.1 1.1 2.5 2 0 0 2 2 2 0 Putative antitoxin HEAT_2 PF13646.6 CCF49458.1 - 6.7 7.2 17.7 1.4 9.3 0.2 6.1 6 0 0 6 6 6 0 HEAT repeats DUF2862 PF11061.8 CCF49461.1 - 0.2 11.5 0.0 0.44 10.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2862) PHY PF00360.20 CCF49463.1 - 6.4e-27 94.0 0.0 1.2e-26 93.2 0.0 1.3 1 0 0 1 1 1 1 Phytochrome region HATPase_c PF02518.26 CCF49463.1 - 1.4e-20 73.9 0.8 4.7e-20 72.2 0.8 1.9 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 CCF49463.1 - 2.2e-16 60.0 0.1 1.2e-15 57.7 0.1 2.2 1 1 0 1 1 1 1 Response regulator receiver domain GAF PF01590.26 CCF49463.1 - 3e-12 47.3 0.0 9e-12 45.8 0.0 1.9 1 0 0 1 1 1 1 GAF domain HisKA PF00512.25 CCF49463.1 - 9.9e-12 44.7 1.3 3.7e-11 42.9 1.3 2.1 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain PAS_2 PF08446.11 CCF49463.1 - 3.8e-08 34.0 0.0 1.2e-07 32.4 0.0 1.9 1 0 0 1 1 1 1 PAS fold DUF2615 PF11027.8 CCF49465.1 - 0.12 12.6 0.1 0.23 11.6 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2615) IMPa_N_2 PF18650.1 CCF49466.1 - 0.12 11.6 0.1 1.1 8.5 0.0 2.3 2 1 0 2 2 2 0 Immunomodulating metalloprotease N-terminal domain Hist_deacetyl PF00850.19 CCF49467.1 - 7.1e-41 140.7 1.7 1.5e-40 139.6 1.7 1.6 1 1 0 1 1 1 1 Histone deacetylase domain RIO1 PF01163.22 CCF49468.1 - 1.7e-65 220.1 0.0 1.7e-65 220.1 0.0 1.7 2 0 0 2 2 2 1 RIO1 family RhoGAP PF00620.27 CCF49469.1 - 4.6e-08 33.0 0.0 1.6e-07 31.2 0.0 1.9 1 0 0 1 1 1 1 RhoGAP domain FCH PF00611.23 CCF49469.1 - 0.0054 17.0 0.0 0.019 15.2 0.0 2.0 1 0 0 1 1 1 1 Fes/CIP4, and EFC/F-BAR homology domain Pkinase PF00069.25 CCF49470.1 - 5.8e-62 209.4 0.0 5.9e-61 206.1 0.0 2.3 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF49470.1 - 3e-33 115.2 0.0 5e-33 114.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase HR1 PF02185.16 CCF49470.1 - 2.3e-23 82.1 21.4 2.3e-12 46.9 8.8 2.6 2 0 0 2 2 2 2 Hr1 repeat C1_1 PF00130.22 CCF49470.1 - 3.9e-20 71.5 26.5 2.4e-11 43.3 9.5 2.4 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) Pkinase_C PF00433.24 CCF49470.1 - 1.8e-08 34.9 0.7 6.3e-08 33.2 0.7 2.1 1 0 0 1 1 1 1 Protein kinase C terminal domain C2 PF00168.30 CCF49470.1 - 8.6e-07 29.2 0.0 1.7e-06 28.2 0.0 1.5 1 0 0 1 1 1 1 C2 domain Kinase-like PF14531.6 CCF49470.1 - 0.016 14.6 0.0 0.046 13.0 0.0 1.8 2 0 0 2 2 2 0 Kinase-like FTA2 PF13095.6 CCF49470.1 - 0.02 14.5 0.0 1.8 8.2 0.0 2.5 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Uds1 PF15456.6 CCF49470.1 - 1.4 9.1 9.7 15 5.7 5.3 2.9 2 1 0 2 2 2 0 Up-regulated During Septation C1_2 PF03107.16 CCF49470.1 - 9.5 6.6 21.5 8.5 6.8 7.1 2.4 2 0 0 2 2 2 0 C1 domain Asp PF00026.23 CCF49471.1 - 7.2e-17 61.8 0.0 7.2e-17 61.8 0.0 2.8 2 1 0 2 2 2 1 Eukaryotic aspartyl protease DUF4381 PF14316.6 CCF49471.1 - 0.023 15.0 0.3 0.023 15.0 0.3 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4381) GT87 PF09594.10 CCF49471.1 - 0.044 13.5 0.7 0.073 12.8 0.7 1.3 1 0 0 1 1 1 0 Glycosyltransferase family 87 Tad PF13400.6 CCF49471.1 - 0.73 10.2 4.0 2.5 8.5 4.0 1.9 1 0 0 1 1 1 0 Putative Flp pilus-assembly TadE/G-like ADH_N PF08240.12 CCF49473.1 - 1.5e-31 108.5 0.2 2.6e-31 107.8 0.2 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CCF49473.1 - 3.6e-18 65.8 0.1 5.8e-18 65.1 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 CCF49473.1 - 2e-05 24.2 0.0 3.2e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus AlaDh_PNT_C PF01262.21 CCF49473.1 - 0.00028 20.2 0.2 0.00042 19.7 0.2 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain ADH_N_assoc PF13823.6 CCF49473.1 - 0.036 14.0 0.1 0.082 12.9 0.1 1.6 1 0 0 1 1 1 0 Alcohol dehydrogenase GroES-associated TrkA_N PF02254.18 CCF49473.1 - 0.077 13.3 0.1 0.14 12.4 0.1 1.5 1 0 0 1 1 1 0 TrkA-N domain Ras PF00071.22 CCF49475.1 - 1.5e-56 190.4 0.0 1.8e-56 190.2 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CCF49475.1 - 1.2e-21 77.1 0.0 1.7e-21 76.7 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CCF49475.1 - 1.2e-06 28.1 0.0 1.9e-06 27.4 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 CCF49475.1 - 0.00024 20.6 0.0 0.00033 20.1 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit ThiF PF00899.21 CCF49476.1 - 1.2e-40 139.4 0.0 4.2e-40 137.6 0.0 1.8 2 1 0 2 2 2 1 ThiF family Sacchrp_dh_NADP PF03435.18 CCF49476.1 - 0.0051 17.1 0.1 0.12 12.6 0.1 2.6 1 1 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain FAD_binding_3 PF01494.19 CCF49476.1 - 0.036 13.3 0.1 0.06 12.6 0.1 1.3 1 0 0 1 1 1 0 FAD binding domain ILVD_EDD PF00920.21 CCF49477.1 - 1.4e-200 667.3 0.5 1.6e-200 667.1 0.5 1.0 1 0 0 1 1 1 1 Dehydratase family AWPM-19 PF05512.11 CCF49478.1 - 0.0041 17.3 3.9 0.0041 17.3 3.9 1.7 2 0 0 2 2 2 1 AWPM-19-like family TMEM208_SND2 PF05620.11 CCF49479.1 - 8.3e-48 162.3 2.6 1.3e-47 161.7 2.6 1.3 1 1 0 1 1 1 1 SRP-independent targeting protein 2/TMEM208 DEC-1_N PF04625.13 CCF49480.1 - 0.11 11.4 1.6 0.13 11.3 1.6 1.2 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region HA2 PF04408.23 CCF49481.1 - 8.3e-21 74.3 0.0 8.3e-21 74.3 0.0 3.7 3 1 0 3 3 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 CCF49481.1 - 2.3e-20 72.7 0.2 7.5e-20 71.1 0.2 1.9 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 CCF49481.1 - 3.4e-15 56.3 0.0 9.3e-15 54.9 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 CCF49481.1 - 3.3e-08 33.5 0.0 8.8e-08 32.1 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase AAA_22 PF13401.6 CCF49481.1 - 1.2e-05 25.6 0.1 4.4e-05 23.8 0.1 2.0 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 CCF49481.1 - 1.9e-05 24.5 0.0 6.9e-05 22.7 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 CCF49481.1 - 0.00013 22.3 0.4 0.0014 19.0 0.0 2.3 2 0 0 2 2 2 1 AAA domain T2SSE PF00437.20 CCF49481.1 - 0.00036 19.7 0.0 0.00068 18.8 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein SRP54 PF00448.22 CCF49481.1 - 0.0011 18.7 0.1 0.0035 17.0 0.1 1.9 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain FtsK_SpoIIIE PF01580.18 CCF49481.1 - 0.026 13.9 0.0 0.064 12.6 0.0 1.6 1 0 0 1 1 1 0 FtsK/SpoIIIE family Flavi_DEAD PF07652.14 CCF49481.1 - 0.042 13.8 0.0 0.11 12.5 0.0 1.6 1 0 0 1 1 1 0 Flavivirus DEAD domain AAA_16 PF13191.6 CCF49481.1 - 0.047 14.1 0.6 0.15 12.4 0.0 2.3 2 0 0 2 2 2 0 AAA ATPase domain Atg14 PF10186.9 CCF49482.1 - 4.4e-23 81.9 0.0 5.3e-12 45.5 0.0 2.6 1 1 1 2 2 2 2 Vacuolar sorting 38 and autophagy-related subunit 14 Sec8_exocyst PF04048.14 CCF49482.1 - 0.16 11.9 2.8 4.5 7.1 0.7 2.4 2 0 0 2 2 2 0 Sec8 exocyst complex component specific domain zf-rbx1 PF12678.7 CCF49485.1 - 9.2e-26 89.9 13.1 1.7e-25 89.1 13.1 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 CCF49485.1 - 1.3e-17 63.7 12.2 1.7e-17 63.2 12.2 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_2 PF13639.6 CCF49485.1 - 1.7e-06 28.2 17.0 0.0001 22.5 17.0 2.4 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 CCF49485.1 - 0.0004 20.2 12.2 0.0043 16.9 12.2 2.4 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 CCF49485.1 - 0.00065 19.5 15.3 0.054 13.3 15.3 2.4 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 CCF49485.1 - 0.025 14.4 11.8 0.099 12.5 4.9 2.6 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 CCF49485.1 - 0.27 10.9 15.2 0.085 12.5 5.3 2.3 1 1 1 2 2 2 0 Zinc-ribbon, C4HC2 type zf-RING_UBOX PF13445.6 CCF49485.1 - 0.28 11.2 8.2 1.3 9.1 8.2 2.2 1 1 0 1 1 1 0 RING-type zinc-finger FANCL_C PF11793.8 CCF49485.1 - 0.49 10.6 14.6 0.087 13.0 9.1 2.2 1 1 1 2 2 2 0 FANCL C-terminal domain zf-RING_5 PF14634.6 CCF49485.1 - 1.4 8.9 12.2 7.5 6.6 12.2 2.3 1 1 0 1 1 1 0 zinc-RING finger domain zf-C3HC4_4 PF15227.6 CCF49485.1 - 5 7.4 9.3 0.36 11.0 0.7 2.5 2 1 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-RING_11 PF17123.5 CCF49485.1 - 6 6.7 21.2 43 4.0 17.0 2.7 2 1 0 2 2 2 0 RING-like zinc finger WD40 PF00400.32 CCF49486.1 - 1.1e-22 79.8 30.1 0.0018 19.0 0.1 11.9 11 3 1 12 12 12 8 WD domain, G-beta repeat CTP_transf_like PF01467.26 CCF49486.1 - 1.7e-06 28.3 0.0 5.8e-06 26.6 0.0 2.0 2 0 0 2 2 2 1 Cytidylyltransferase-like ATE_C PF04377.15 CCF49489.1 - 2.3e-46 157.7 0.1 4.2e-46 156.9 0.1 1.4 1 0 0 1 1 1 1 Arginine-tRNA-protein transferase, C terminus ATE_N PF04376.13 CCF49489.1 - 2.3e-27 95.2 0.6 5.2e-27 94.1 0.6 1.7 1 0 0 1 1 1 1 Arginine-tRNA-protein transferase, N terminus Kelch_2 PF07646.15 CCF49489.1 - 0.051 13.6 0.2 0.53 10.4 0.0 2.5 2 0 0 2 2 2 0 Kelch motif DSS1_SEM1 PF05160.13 CCF49490.1 - 1.4e-20 73.1 10.5 2.5e-20 72.3 10.5 1.4 1 1 0 1 1 1 1 DSS1/SEM1 family SRA1 PF07304.11 CCF49491.1 - 4e-07 29.9 0.1 1.9e-06 27.7 0.0 2.4 2 0 0 2 2 2 1 Steroid receptor RNA activator (SRA1) WD40 PF00400.32 CCF49491.1 - 0.00015 22.5 5.7 5.2 8.1 0.0 5.5 6 0 0 6 6 6 2 WD domain, G-beta repeat Prp18 PF02840.15 CCF49491.1 - 0.013 15.6 0.0 0.032 14.3 0.0 1.6 1 0 0 1 1 1 0 Prp18 domain rve PF00665.26 CCF49492.1 - 1.3e-10 41.5 0.1 2.1e-10 40.8 0.1 1.3 1 0 0 1 1 1 1 Integrase core domain DUF1681 PF07933.14 CCF49495.1 - 1.6e-53 180.4 0.0 1.9e-53 180.2 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1681) DUF3712 PF12505.8 CCF49496.1 - 3e-32 111.5 0.7 5.5e-22 78.3 0.1 5.8 7 0 0 7 7 7 3 Protein of unknown function (DUF3712) LEA_2 PF03168.13 CCF49496.1 - 0.00015 22.2 0.0 0.095 13.2 0.0 4.2 4 0 0 4 4 4 1 Late embryogenesis abundant protein MlaD PF02470.20 CCF49496.1 - 0.057 13.7 0.0 1.8 8.9 0.0 3.3 3 0 0 3 3 3 0 MlaD protein RVT_2 PF07727.14 CCF49498.1 - 6.3e-52 176.6 0.1 7.6e-52 176.4 0.1 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve_3 PF13683.6 CCF49499.1 - 0.16 11.8 0.0 0.3 10.9 0.0 1.4 1 0 0 1 1 1 0 Integrase core domain zf-CCHC_4 PF14392.6 CCF49500.1 - 2.9 7.7 7.2 5.5 6.8 7.2 1.5 1 0 0 1 1 1 0 Zinc knuckle ANAPC4 PF12896.7 CCF49502.1 - 3.6e-22 78.9 0.0 8.3e-22 77.7 0.0 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 4 ETF PF01012.21 CCF49503.1 - 1.1e-45 155.8 0.8 1.7e-45 155.1 0.8 1.3 1 0 0 1 1 1 1 Electron transfer flavoprotein domain ETF_alpha PF00766.19 CCF49503.1 - 3.9e-33 113.3 0.1 9.4e-33 112.1 0.1 1.7 1 0 0 1 1 1 1 Electron transfer flavoprotein FAD-binding domain DHH PF01368.20 CCF49504.1 - 0.0074 16.5 0.0 0.015 15.5 0.0 1.5 1 0 0 1 1 1 1 DHH family Ion_trans_N PF08412.10 CCF49504.1 - 0.072 12.7 0.0 0.35 10.5 0.0 2.0 2 0 0 2 2 2 0 Ion transport protein N-terminal Ku PF02735.16 CCF49505.1 - 2.6e-22 79.5 0.1 5e-22 78.6 0.1 1.5 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain Ku_PK_bind PF08785.11 CCF49505.1 - 5.2e-21 75.0 0.7 1.8e-20 73.3 0.4 2.1 2 0 0 2 2 2 1 Ku C terminal domain like VWA_2 PF13519.6 CCF49505.1 - 0.012 16.2 0.0 0.05 14.3 0.0 2.2 2 0 0 2 2 2 0 von Willebrand factor type A domain Isochorismatase PF00857.20 CCF49506.1 - 3.6e-29 102.2 0.1 4.8e-29 101.8 0.1 1.2 1 0 0 1 1 1 1 Isochorismatase family SIR2 PF02146.17 CCF49507.1 - 9.7e-26 90.8 0.0 9.9e-21 74.5 0.0 3.3 3 0 0 3 3 3 2 Sir2 family Rdx PF10262.9 CCF49508.1 - 4.5e-25 87.6 0.0 6.7e-25 87.1 0.0 1.3 1 0 0 1 1 1 1 Rdx family TMEM135_C_rich PF15982.5 CCF49509.1 - 0.017 15.7 0.9 0.044 14.4 0.1 2.0 2 0 0 2 2 2 0 N-terminal cysteine-rich region of Transmembrane protein 135 RVT_2 PF07727.14 CCF49512.1 - 3.8e-08 33.3 0.1 4.6e-08 33.0 0.1 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF3489 PF11994.8 CCF49513.1 - 0.041 13.9 0.3 2 8.5 0.0 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3489) WW PF00397.26 CCF49513.1 - 0.16 12.1 0.7 0.46 10.6 0.7 1.8 1 0 0 1 1 1 0 WW domain DUF4781 PF16013.5 CCF49513.1 - 6.3 5.5 6.9 0.98 8.2 1.3 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4781) EB1 PF03271.17 CCF49514.1 - 1.2e-17 63.8 0.3 2.1e-17 63.1 0.3 1.4 1 0 0 1 1 1 1 EB1-like C-terminal motif CH PF00307.31 CCF49514.1 - 0.00018 21.7 0.1 0.00041 20.5 0.1 1.6 2 0 0 2 2 2 1 Calponin homology (CH) domain CH_2 PF06294.11 CCF49514.1 - 0.0027 17.8 0.1 0.0047 17.0 0.1 1.4 1 0 0 1 1 1 1 CH-like domain in sperm protein Homeodomain PF00046.29 CCF49515.1 - 3.2e-13 49.3 1.7 8.1e-13 48.0 1.7 1.7 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 CCF49515.1 - 0.13 12.2 0.2 0.13 12.2 0.2 2.5 3 0 0 3 3 3 0 Homeobox KN domain DUF2267 PF10025.9 CCF49515.1 - 0.15 12.4 1.9 0.39 11.0 0.8 2.2 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2267) YdaS_antitoxin PF15943.5 CCF49515.1 - 0.21 11.5 0.1 0.39 10.6 0.1 1.4 1 0 0 1 1 1 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT Mito_carr PF00153.27 CCF49517.1 - 3.7e-32 110.1 6.2 1e-15 57.4 0.0 3.2 2 1 0 3 3 3 3 Mitochondrial carrier protein NAD_binding_8 PF13450.6 CCF49518.1 - 1.6e-10 41.0 0.0 1.5e-06 28.4 0.0 2.8 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.19 CCF49518.1 - 0.063 12.5 0.0 0.098 11.9 0.0 1.2 1 0 0 1 1 1 0 FAD binding domain DUF2009 PF09418.10 CCF49518.1 - 0.27 10.3 0.1 0.41 9.7 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2009) HA2 PF04408.23 CCF49519.1 - 1e-16 61.1 0.6 4.4e-16 59.1 0.0 2.4 2 0 0 2 2 2 1 Helicase associated domain (HA2) Helicase_C PF00271.31 CCF49519.1 - 4.2e-14 52.8 0.0 9.6e-14 51.7 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain dsrm PF00035.26 CCF49519.1 - 1.1e-08 35.6 0.1 0.00042 21.0 0.0 2.9 2 0 0 2 2 2 2 Double-stranded RNA binding motif DEAD PF00270.29 CCF49519.1 - 2.1e-06 27.6 0.2 4.9e-06 26.4 0.2 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_19 PF13245.6 CCF49519.1 - 0.0056 17.0 0.0 0.0056 17.0 0.0 1.8 2 0 0 2 2 2 1 AAA domain OB_NTP_bind PF07717.16 CCF49519.1 - 0.021 15.2 0.0 0.076 13.4 0.0 2.0 1 0 0 1 1 1 0 Oligonucleotide/oligosaccharide-binding (OB)-fold Fungal_trans PF04082.18 CCF49520.1 - 4e-08 32.6 0.2 8.6e-08 31.5 0.2 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF49520.1 - 0.012 15.7 9.2 0.029 14.5 9.2 1.7 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain Ribophorin_I PF04597.14 CCF49521.1 - 5.6e-123 411.4 0.0 6.5e-123 411.2 0.0 1.0 1 0 0 1 1 1 1 Ribophorin I CDC45 PF02724.14 CCF49522.1 - 7.9e-226 751.3 0.0 9.1e-226 751.1 0.0 1.0 1 0 0 1 1 1 1 CDC45-like protein LeuA_dimer PF08502.10 CCF49522.1 - 0.07 13.0 0.0 9.4 6.1 0.0 2.5 2 0 0 2 2 2 0 LeuA allosteric (dimerisation) domain Apt1 PF10351.9 CCF49522.1 - 0.24 10.2 5.6 0.36 9.6 5.6 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain CCDC106 PF15794.5 CCF49522.1 - 1.3 8.7 5.9 2.4 7.8 5.9 1.3 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 RasGEF PF00617.19 CCF49525.1 - 1.7e-42 145.7 0.0 2.9e-42 144.8 0.0 1.4 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 CCF49525.1 - 2e-06 28.0 0.0 5.2e-06 26.6 0.0 1.7 1 0 0 1 1 1 1 RasGEF N-terminal motif Arf PF00025.21 CCF49525.1 - 0.15 11.5 0.0 0.29 10.5 0.0 1.4 1 0 0 1 1 1 0 ADP-ribosylation factor family Aminotran_5 PF00266.19 CCF49526.1 - 5.7e-87 292.1 0.0 1.4e-86 290.7 0.0 1.6 1 1 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 CCF49526.1 - 0.00019 20.9 0.0 0.00025 20.5 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Cys_Met_Meta_PP PF01053.20 CCF49526.1 - 0.14 10.6 0.0 0.21 10.1 0.0 1.2 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme ThrE PF06738.12 CCF49527.1 - 1.9e-59 201.0 4.6 1.9e-59 201.0 4.6 2.5 2 1 0 2 2 2 2 Putative threonine/serine exporter ThrE_2 PF12821.7 CCF49527.1 - 1.3e-07 31.8 3.6 1.3e-07 31.8 3.6 2.4 2 0 0 2 2 2 1 Threonine/Serine exporter, ThrE Spt20 PF12090.8 CCF49527.1 - 3.5 7.2 16.0 0.18 11.4 7.3 2.4 2 0 0 2 2 2 0 Spt20 family SVIP PF15811.5 CCF49528.1 - 0.016 15.7 4.7 0.016 15.7 4.7 1.8 2 1 0 2 2 2 0 Small VCP/p97-interacting protein Ribosomal_L22 PF00237.19 CCF49529.1 - 6.7e-23 80.9 0.1 1.6e-22 79.6 0.1 1.7 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e PGM_PMM_III PF02880.16 CCF49529.1 - 0.03 14.5 0.0 4.4 7.5 0.0 2.3 2 0 0 2 2 2 0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III DDE_Tnp_ISL3 PF01610.17 CCF49530.1 - 0.033 13.9 0.1 0.057 13.1 0.1 1.4 1 0 0 1 1 1 0 Transposase Glyco_transf_90 PF05686.12 CCF49532.1 - 9.2e-15 54.4 1.6 1.5e-13 50.4 0.1 2.6 3 0 0 3 3 3 2 Glycosyl transferase family 90 Acyl_transf_3 PF01757.22 CCF49533.1 - 1.2e-13 50.9 29.5 1.7e-13 50.4 29.5 1.2 1 0 0 1 1 1 1 Acyltransferase family Nuc_sug_transp PF04142.15 CCF49534.1 - 4.3e-50 170.7 13.0 4.3e-44 151.0 10.4 2.1 2 0 0 2 2 2 2 Nucleotide-sugar transporter EamA PF00892.20 CCF49534.1 - 0.00019 21.6 28.2 0.003 17.7 3.1 3.2 3 0 0 3 3 3 2 EamA-like transporter family Multi_Drug_Res PF00893.19 CCF49534.1 - 0.053 14.2 1.1 0.053 14.2 1.1 3.1 3 0 0 3 3 3 0 Small Multidrug Resistance protein TMEM234 PF10639.9 CCF49534.1 - 0.63 10.1 8.5 1.5 8.9 2.0 2.9 2 1 1 3 3 3 0 Putative transmembrane family 234 Stealth_CR3 PF17102.5 CCF49535.1 - 0.00049 20.0 0.1 0.0028 17.5 0.1 2.3 1 1 0 1 1 1 1 Stealth protein CR3, conserved region 3 Arrestin_C PF02752.22 CCF49536.1 - 0.0074 16.8 0.0 0.67 10.4 0.0 2.4 2 0 0 2 2 2 2 Arrestin (or S-antigen), C-terminal domain Acetyltransf_1 PF00583.25 CCF49537.1 - 5.9e-16 58.7 0.0 7.2e-16 58.5 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CCF49537.1 - 2.2e-13 50.2 0.0 3.1e-13 49.8 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CCF49537.1 - 1.4e-11 44.6 0.0 1.9e-11 44.2 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 CCF49537.1 - 2.1e-06 27.8 0.0 3.2e-06 27.2 0.0 1.3 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_3 PF13302.7 CCF49537.1 - 8.9e-06 26.4 0.0 1e-05 26.2 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CCF49537.1 - 0.0042 17.0 0.0 0.0067 16.4 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_4 PF13420.7 CCF49537.1 - 0.026 14.7 0.0 0.06 13.5 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 CCF49537.1 - 0.08 12.6 0.0 0.09 12.5 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Fungal_trans PF04082.18 CCF49538.1 - 6.6e-10 38.5 0.5 6.6e-10 38.5 0.5 1.4 2 0 0 2 2 2 1 Fungal specific transcription factor domain SAP PF02037.27 CCF49540.1 - 7.2e-05 22.4 0.1 0.00024 20.8 0.1 2.0 1 0 0 1 1 1 1 SAP domain Phage_tail_L PF05100.12 CCF49540.1 - 0.016 14.5 0.0 0.035 13.4 0.1 1.5 1 1 0 1 1 1 0 Phage minor tail protein L zf-C2H2_4 PF13894.6 CCF49540.1 - 0.029 15.2 1.9 0.19 12.6 0.1 3.1 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_11 PF16622.5 CCF49540.1 - 0.63 9.9 5.5 7.5 6.4 0.0 2.9 3 0 0 3 3 3 0 zinc-finger C2H2-type zf-Di19 PF05605.12 CCF49540.1 - 1.4 9.3 6.9 0.19 12.0 1.1 2.5 3 0 0 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding SNF2_N PF00176.23 CCF49541.1 - 4e-61 206.7 0.1 6.8e-61 205.9 0.1 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain DUF4208 PF13907.6 CCF49541.1 - 4.7e-27 94.3 2.6 5.2e-27 94.1 0.4 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF4208) Chromo PF00385.24 CCF49541.1 - 3.3e-21 74.9 0.9 3.6e-14 52.4 0.1 2.8 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain Helicase_C PF00271.31 CCF49541.1 - 4e-19 69.0 0.0 1.2e-18 67.5 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 CCF49541.1 - 9.4e-08 32.2 0.0 9.4e-08 32.2 0.0 2.8 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit Cdh1_DBD_1 PF18196.1 CCF49541.1 - 9.1e-07 29.2 0.2 9.1e-07 29.2 0.2 3.4 3 0 0 3 3 3 1 Chromodomain helicase DNA-binding domain 1 CDH1_2_SANT_HL1 PF18375.1 CCF49541.1 - 0.0079 16.8 0.3 0.0079 16.8 0.3 2.7 2 0 0 2 2 2 1 CDH1/2 SANT-Helical linker 1 CHDCT2 PF08074.11 CCF49541.1 - 0.064 13.4 0.0 0.064 13.4 0.0 4.3 6 0 0 6 6 6 0 CHDCT2 (NUC038) domain SelP_N PF04592.14 CCF49541.1 - 6.7 6.0 24.5 19 4.6 24.5 1.7 1 0 0 1 1 1 0 Selenoprotein P, N terminal region LysM PF01476.20 CCF49542.1 - 0.13 12.3 0.0 0.3 11.2 0.0 1.7 1 0 0 1 1 1 0 LysM domain GFA PF04828.14 CCF49543.1 - 1.2e-11 44.8 2.4 2.1e-11 44.0 2.4 1.4 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme Herpes_glycop_D PF01537.17 CCF49544.1 - 0.016 15.4 0.0 0.016 15.3 0.0 1.1 1 0 0 1 1 1 0 Herpesvirus glycoprotein D/GG/GX domain ATP-synt PF00231.19 CCF49545.1 - 5.5e-78 262.5 2.9 6.3e-78 262.3 2.9 1.0 1 0 0 1 1 1 1 ATP synthase eIF-5_eIF-2B PF01873.17 CCF49546.1 - 2.7e-42 143.3 0.2 4.7e-42 142.6 0.2 1.3 1 0 0 1 1 1 1 Domain found in IF2B/IF5 TF_Zn_Ribbon PF08271.12 CCF49546.1 - 0.018 14.6 0.2 0.044 13.3 0.2 1.7 1 0 0 1 1 1 0 TFIIB zinc-binding zf_C2H2_13 PF18508.1 CCF49546.1 - 0.71 9.5 3.7 2.5 7.8 0.3 2.2 1 1 1 2 2 2 0 Zinc finger domain Hid1 PF12722.7 CCF49546.1 - 2.2 6.3 6.1 2.8 5.9 6.1 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein RVT_2 PF07727.14 CCF49547.1 - 3.6e-50 170.9 0.4 4.2e-50 170.7 0.4 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1810 PF08837.11 CCF49548.1 - 0.072 12.9 0.0 0.093 12.5 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1810) ABC_membrane PF00664.23 CCF49549.1 - 3.4e-81 272.9 14.4 1.2e-44 153.0 4.3 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 CCF49549.1 - 4.6e-61 205.3 0.0 1.4e-30 106.6 0.0 3.5 2 1 0 2 2 2 2 ABC transporter SMC_N PF02463.19 CCF49549.1 - 5.2e-13 49.0 0.2 2e-05 24.2 0.0 4.0 2 2 0 2 2 2 2 RecF/RecN/SMC N terminal domain ABC_ATPase PF09818.9 CCF49549.1 - 5.2e-08 32.1 0.0 0.014 14.2 0.0 3.1 3 0 0 3 3 3 2 Predicted ATPase of the ABC class RsgA_GTPase PF03193.16 CCF49549.1 - 6.6e-08 32.6 0.0 0.0022 17.9 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase AAA_29 PF13555.6 CCF49549.1 - 2.2e-07 30.5 0.6 0.0055 16.4 0.1 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_15 PF13175.6 CCF49549.1 - 1.6e-06 28.1 0.0 0.07 12.8 0.0 2.5 2 0 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.6 CCF49549.1 - 2e-06 28.1 0.1 0.019 15.2 0.0 3.4 2 1 0 2 2 2 2 AAA domain AAA_16 PF13191.6 CCF49549.1 - 1e-05 26.0 3.1 0.038 14.4 0.0 3.4 3 1 0 3 3 2 2 AAA ATPase domain AAA_23 PF13476.6 CCF49549.1 - 3.8e-05 24.3 1.1 0.013 16.0 0.1 2.7 2 1 0 2 2 2 1 AAA domain AAA_25 PF13481.6 CCF49549.1 - 5.1e-05 22.9 0.0 0.23 11.0 0.0 3.9 4 0 0 4 4 4 1 AAA domain AAA_18 PF13238.6 CCF49549.1 - 0.00011 22.7 0.0 0.64 10.6 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_7 PF12775.7 CCF49549.1 - 0.00017 21.2 0.0 0.12 11.9 0.0 2.6 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA_21 PF13304.6 CCF49549.1 - 0.00023 21.1 0.0 0.72 9.6 0.0 3.5 2 1 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_33 PF13671.6 CCF49549.1 - 0.00044 20.4 0.0 0.29 11.3 0.0 3.1 3 0 0 3 3 3 1 AAA domain SbcCD_C PF13558.6 CCF49549.1 - 0.006 16.8 1.8 3.7 7.9 0.3 3.6 2 2 0 2 2 2 1 Putative exonuclease SbcCD, C subunit DUF3987 PF13148.6 CCF49549.1 - 0.006 15.6 0.8 0.019 14.0 0.4 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF3987) MMR_HSR1 PF01926.23 CCF49549.1 - 0.014 15.5 0.0 1.5 9.0 0.0 2.8 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_30 PF13604.6 CCF49549.1 - 0.026 14.3 0.2 1.4 8.6 0.0 2.9 3 0 0 3 3 3 0 AAA domain Zeta_toxin PF06414.12 CCF49549.1 - 0.038 13.3 0.0 9.4 5.5 0.0 2.7 2 0 0 2 2 2 0 Zeta toxin DUF87 PF01935.17 CCF49549.1 - 0.046 13.8 1.0 3 7.9 0.0 2.8 3 0 0 3 3 2 0 Helicase HerA, central domain AAA_5 PF07728.14 CCF49549.1 - 0.063 13.3 0.0 2.7 8.0 0.0 3.1 3 0 0 3 3 2 0 AAA domain (dynein-related subfamily) AAA_28 PF13521.6 CCF49549.1 - 0.081 13.2 0.0 14 5.8 0.0 2.6 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 CCF49549.1 - 0.1 13.0 0.0 5.7 7.4 0.0 2.8 2 0 0 2 2 2 0 RNA helicase TFIIF_beta_N PF17683.1 CCF49549.1 - 0.11 13.2 0.1 0.29 11.8 0.1 1.6 1 0 0 1 1 1 0 TFIIF, beta subunit N-terminus G-alpha PF00503.20 CCF49549.1 - 0.11 11.6 0.0 2.4 7.2 0.0 2.2 2 0 0 2 2 2 0 G-protein alpha subunit PRK PF00485.18 CCF49549.1 - 0.14 11.9 0.5 9 6.0 0.0 2.4 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family Cytochrome-c551 PF10643.9 CCF49549.1 - 2 8.0 3.9 3.7 7.1 0.6 2.4 2 0 0 2 2 2 0 Photosystem P840 reaction-centre cytochrome c-551 Asp PF00026.23 CCF49550.1 - 5.1e-29 101.7 0.0 6.3e-29 101.4 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 CCF49550.1 - 4.9e-10 39.9 0.1 3.3e-06 27.5 0.2 3.2 2 1 0 2 2 2 2 Xylanase inhibitor N-terminal TPR_1 PF00515.28 CCF49552.1 - 1.3e-19 69.1 3.0 0.00012 21.7 0.0 5.4 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_11 PF13414.6 CCF49552.1 - 1.9e-15 56.2 1.5 0.001 18.7 0.0 4.5 3 1 1 4 4 4 4 TPR repeat TPR_2 PF07719.17 CCF49552.1 - 2.8e-15 55.1 6.2 0.00044 20.2 0.2 5.6 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_8 PF13181.6 CCF49552.1 - 6.9e-14 50.8 1.9 0.0038 17.3 0.0 5.4 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_14 PF13428.6 CCF49552.1 - 1.7e-11 43.9 1.8 0.028 15.2 0.0 5.8 3 2 2 5 5 5 3 Tetratricopeptide repeat TPR_16 PF13432.6 CCF49552.1 - 3e-10 40.6 4.5 0.0017 19.0 0.0 4.8 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 CCF49552.1 - 5.5e-09 35.4 1.5 0.041 13.9 0.1 4.3 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 CCF49552.1 - 9.7e-09 35.0 5.9 0.0045 17.3 0.0 5.0 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_12 PF13424.6 CCF49552.1 - 1e-08 35.4 3.3 4.5e-05 23.7 0.0 4.1 2 1 2 4 4 4 3 Tetratricopeptide repeat TPR_9 PF13371.6 CCF49552.1 - 1.6e-06 28.2 0.8 0.012 15.7 0.0 3.0 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.6 CCF49552.1 - 4.5e-06 27.1 11.6 0.083 13.4 0.0 4.3 3 2 2 5 5 4 3 Tetratricopeptide repeat TPR_10 PF13374.6 CCF49552.1 - 0.0043 16.9 2.5 0.022 14.6 0.8 3.0 3 0 0 3 3 2 1 Tetratricopeptide repeat TPR_3 PF07720.12 CCF49552.1 - 0.0054 16.7 0.0 2.2 8.4 0.0 3.0 2 0 0 2 2 2 1 Tetratricopeptide repeat DUF3507 PF12015.8 CCF49552.1 - 0.081 12.6 0.0 0.19 11.4 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3507) MIT PF04212.18 CCF49552.1 - 0.14 12.2 2.2 20 5.3 0.0 4.2 4 1 0 4 4 4 0 MIT (microtubule interacting and transport) domain ANAPC3 PF12895.7 CCF49552.1 - 0.23 11.7 8.3 0.34 11.2 0.8 3.1 3 0 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 RPEL PF02755.15 CCF49553.1 - 4.8e-25 86.5 33.4 5.4e-09 35.4 2.0 4.9 5 0 0 5 5 5 4 RPEL repeat Hanta_nucleocap PF00846.18 CCF49553.1 - 0.066 11.6 5.2 0.66 8.4 0.4 2.8 1 1 2 3 3 3 0 Hantavirus nucleocapsid protein MMADHC PF10229.9 CCF49553.1 - 0.077 12.7 0.6 0.24 11.1 0.0 1.8 1 1 1 2 2 2 0 Methylmalonic aciduria and homocystinuria type D protein DnaI_N PF07319.11 CCF49553.1 - 0.14 12.9 1.5 16 6.3 0.1 2.5 1 1 1 2 2 2 0 Primosomal protein DnaI N-terminus Topoisom_I_N PF02919.15 CCF49554.1 - 1.9e-80 269.4 1.6 1.9e-80 269.4 1.6 3.8 3 1 0 3 3 3 1 Eukaryotic DNA topoisomerase I, DNA binding fragment Topoisom_I PF01028.20 CCF49554.1 - 6.8e-79 264.4 3.3 6.8e-79 264.4 3.3 2.4 2 0 0 2 2 2 1 Eukaryotic DNA topoisomerase I, catalytic core Topo_C_assoc PF14370.6 CCF49554.1 - 6.6e-16 58.0 0.6 8.9e-12 44.8 0.2 3.0 2 0 0 2 2 2 2 C-terminal topoisomerase domain NDUF_B12 PF08122.12 CCF49555.1 - 2.1e-17 62.9 0.6 2.4e-17 62.7 0.6 1.1 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B12 subunit family ATP-sulfurylase PF01747.17 CCF49556.1 - 1.3e-87 292.7 0.2 1.9e-87 292.2 0.2 1.2 1 0 0 1 1 1 1 ATP-sulfurylase APS_kinase PF01583.20 CCF49556.1 - 2.2e-55 186.9 0.0 3.4e-55 186.3 0.0 1.3 1 0 0 1 1 1 1 Adenylylsulphate kinase PUA_2 PF14306.6 CCF49556.1 - 9.4e-52 174.9 0.0 1.7e-51 174.1 0.0 1.4 1 0 0 1 1 1 1 PUA-like domain CTP_transf_like PF01467.26 CCF49556.1 - 0.085 13.1 0.1 0.66 10.2 0.1 2.3 1 1 0 1 1 1 0 Cytidylyltransferase-like Mito_carr PF00153.27 CCF49557.1 - 1.6e-44 149.7 8.9 1.5e-17 63.3 0.4 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Med12 PF09497.10 CCF49558.1 - 5.1e-33 113.2 0.1 2.7e-32 110.8 0.0 2.4 2 0 0 2 2 2 1 Transcription mediator complex subunit Med12 Med12-LCEWAV PF12145.8 CCF49558.1 - 6.8e-05 21.9 0.0 0.00021 20.3 0.0 1.7 2 0 0 2 2 2 1 Eukaryotic Mediator 12 subunit domain tRNA-synt_1 PF00133.22 CCF49559.1 - 4.8e-36 124.2 0.0 2e-27 95.8 0.0 3.4 2 1 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 CCF49559.1 - 1.7e-16 60.0 0.0 1.5e-09 37.1 0.0 2.4 2 0 0 2 2 2 2 tRNA synthetases class I (M) Anticodon_1 PF08264.13 CCF49559.1 - 1.2e-12 48.0 0.1 3.3e-12 46.6 0.0 1.7 2 0 0 2 2 2 1 Anticodon-binding domain of tRNA tRNA-synt_1e PF01406.19 CCF49559.1 - 2.1e-06 27.3 0.0 4.6e-06 26.2 0.0 1.5 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain Peptidase_M14 PF00246.24 CCF49560.1 - 4.6e-65 220.3 0.0 1.1e-46 160.0 0.0 2.1 2 0 0 2 2 2 2 Zinc carboxypeptidase WD40 PF00400.32 CCF49561.1 - 1.3e-59 196.8 19.3 2.7e-05 24.8 0.0 12.2 11 1 0 11 11 11 9 WD domain, G-beta repeat Utp13 PF08625.11 CCF49561.1 - 1.4e-37 128.8 0.0 4.2e-37 127.2 0.0 1.9 1 1 0 1 1 1 1 Utp13 specific WD40 associated domain ANAPC4_WD40 PF12894.7 CCF49561.1 - 4e-15 55.9 1.3 0.002 18.4 0.0 8.5 5 3 3 8 8 8 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CCF49561.1 - 3.8e-05 22.8 0.1 2 7.3 0.0 4.8 3 1 1 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 CCF49561.1 - 4.1e-05 22.4 10.0 0.4 9.3 0.9 5.8 5 2 0 5 5 5 3 Nucleoporin Nup120/160 WD40_like PF17005.5 CCF49561.1 - 0.0004 19.8 0.0 0.024 14.0 0.0 2.8 2 0 0 2 2 2 1 WD40-like domain DNA_pol_phi PF04931.13 CCF49561.1 - 3.4 5.6 10.7 8 4.4 10.7 1.6 1 0 0 1 1 1 0 DNA polymerase phi tRNA-synt_1b PF00579.25 CCF49562.1 - 1.5e-66 224.7 0.0 2.1e-66 224.2 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) TyrRSs_C PF16714.5 CCF49562.1 - 7.5e-06 25.8 0.1 1.4e-05 24.9 0.1 1.5 1 0 0 1 1 1 1 Tyrosyl-tRNA synthetase C-terminal domain S4 PF01479.25 CCF49562.1 - 5.5e-05 22.8 0.1 0.00012 21.7 0.1 1.6 1 0 0 1 1 1 1 S4 domain MMR_HSR1 PF01926.23 CCF49563.1 - 1.8e-16 60.2 0.0 1.5e-13 50.8 0.0 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase FeoB_N PF02421.18 CCF49563.1 - 7.4e-10 38.6 0.0 4.5e-05 23.0 0.0 2.3 2 0 0 2 2 2 2 Ferrous iron transport protein B RsgA_GTPase PF03193.16 CCF49563.1 - 1.4e-06 28.3 0.5 0.098 12.6 0.1 2.9 1 1 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 CCF49563.1 - 8.8e-05 22.1 0.6 0.0097 15.5 0.0 3.5 3 1 1 4 4 4 1 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 CCF49563.1 - 0.0011 19.0 0.5 0.044 13.9 0.2 2.8 2 1 0 2 2 2 1 Dynamin family HD_2 PF12917.7 CCF49563.1 - 0.11 12.2 0.0 0.25 11.1 0.0 1.5 1 0 0 1 1 1 0 HD containing hydrolase-like enzyme ABC_tran PF00005.27 CCF49563.1 - 0.44 11.1 2.5 15 6.1 0.0 3.1 3 0 0 3 3 3 0 ABC transporter PALP PF00291.25 CCF49564.1 - 1.8e-79 267.2 0.6 2.7e-79 266.7 0.6 1.2 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Thr_dehydrat_C PF00585.18 CCF49564.1 - 2e-41 139.7 0.0 1.2e-24 85.9 0.0 3.7 4 0 0 4 4 4 3 C-terminal regulatory domain of Threonine dehydratase ABC_membrane PF00664.23 CCF49565.1 - 6.3e-91 304.8 26.5 9.4e-48 163.2 10.1 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 CCF49565.1 - 2.1e-62 209.7 0.2 4.9e-32 111.3 0.1 2.6 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 CCF49565.1 - 3.4e-12 46.3 1.5 0.00032 20.2 0.0 3.7 2 2 0 3 3 3 2 RecF/RecN/SMC N terminal domain ABC_ATPase PF09818.9 CCF49565.1 - 1.1e-06 27.8 0.1 0.00099 18.0 0.0 2.4 2 0 0 2 2 2 2 Predicted ATPase of the ABC class AAA_22 PF13401.6 CCF49565.1 - 1.3e-06 28.7 2.6 0.22 11.8 0.0 4.7 4 1 1 5 5 4 2 AAA domain AAA_25 PF13481.6 CCF49565.1 - 6e-06 26.0 0.0 1.3 8.6 0.0 4.4 4 0 0 4 4 4 1 AAA domain AAA_16 PF13191.6 CCF49565.1 - 1.6e-05 25.3 3.1 0.21 11.9 0.7 3.5 2 2 0 2 2 2 2 AAA ATPase domain AAA_30 PF13604.6 CCF49565.1 - 6.1e-05 22.8 0.2 0.12 12.1 0.0 3.7 5 0 0 5 5 4 1 AAA domain AAA_29 PF13555.6 CCF49565.1 - 0.00014 21.6 1.2 0.58 9.9 0.1 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain Zeta_toxin PF06414.12 CCF49565.1 - 0.00025 20.4 0.0 0.03 13.6 0.0 2.6 2 0 0 2 2 2 1 Zeta toxin AAA_21 PF13304.6 CCF49565.1 - 0.00046 20.1 1.9 3.1 7.5 0.0 3.6 2 1 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system SbcCD_C PF13558.6 CCF49565.1 - 0.0017 18.6 6.0 0.75 10.1 0.6 4.1 2 2 0 2 2 2 2 Putative exonuclease SbcCD, C subunit G-alpha PF00503.20 CCF49565.1 - 0.0028 16.9 0.1 0.37 9.9 0.0 2.4 2 0 0 2 2 2 1 G-protein alpha subunit AAA_15 PF13175.6 CCF49565.1 - 0.0029 17.4 0.0 0.32 10.7 0.0 2.3 2 0 0 2 2 2 1 AAA ATPase domain Mg_chelatase PF01078.21 CCF49565.1 - 0.0034 16.8 0.0 0.019 14.4 0.0 2.2 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI RsgA_GTPase PF03193.16 CCF49565.1 - 0.0047 16.9 0.0 3.2 7.6 0.0 2.4 2 0 0 2 2 2 1 RsgA GTPase AAA_33 PF13671.6 CCF49565.1 - 0.0047 17.1 0.1 1.2 9.2 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 CCF49565.1 - 0.0069 16.9 0.0 1.2 9.6 0.0 3.0 3 0 0 3 3 3 1 AAA domain CENP-L PF13092.6 CCF49565.1 - 0.011 15.9 0.0 2.2 8.5 0.0 2.8 2 1 0 2 2 2 0 Kinetochore complex Sim4 subunit Fta1 AAA_5 PF07728.14 CCF49565.1 - 0.022 14.7 0.0 1.5 8.8 0.0 3.0 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_24 PF13479.6 CCF49565.1 - 0.074 12.8 0.4 13 5.5 0.0 2.9 3 0 0 3 3 3 0 AAA domain APS_kinase PF01583.20 CCF49565.1 - 0.081 12.8 0.4 0.36 10.7 0.0 2.0 2 0 0 2 2 2 0 Adenylylsulphate kinase AAA_17 PF13207.6 CCF49565.1 - 0.11 12.9 1.0 6.2 7.3 0.0 3.6 3 0 0 3 3 3 0 AAA domain DEAD PF00270.29 CCF49565.1 - 0.2 11.4 3.6 5.1 6.8 0.1 3.5 2 2 0 2 2 2 0 DEAD/DEAH box helicase PRK PF00485.18 CCF49565.1 - 0.42 10.3 1.9 22 4.7 0.0 2.7 3 0 0 3 3 3 0 Phosphoribulokinase / Uridine kinase family DUF87 PF01935.17 CCF49565.1 - 0.64 10.1 6.3 3.1 7.8 0.1 3.3 3 0 0 3 3 3 0 Helicase HerA, central domain LRR_8 PF13855.6 CCF49566.1 - 3.9e-13 48.9 12.4 6.3e-10 38.7 6.7 2.9 3 0 0 3 3 3 2 Leucine rich repeat LRR_4 PF12799.7 CCF49566.1 - 2.8e-11 43.4 12.9 7.6e-05 23.0 3.4 4.4 2 1 4 6 6 6 4 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 CCF49566.1 - 0.0018 18.2 17.9 1.1 9.5 0.5 5.5 5 0 0 5 5 5 3 Leucine Rich repeat LRR_9 PF14580.6 CCF49566.1 - 0.0057 16.2 0.4 0.026 14.0 0.1 2.0 1 1 2 3 3 3 2 Leucine-rich repeat Macoilin PF09726.9 CCF49566.1 - 0.9 8.0 6.5 1.6 7.2 6.5 1.3 1 0 0 1 1 1 0 Macoilin family LRR_1 PF00560.33 CCF49566.1 - 2.7 8.9 18.1 9.7 7.2 1.6 5.5 4 1 0 4 4 4 0 Leucine Rich Repeat EF_TS PF00889.19 CCF49567.1 - 4.1e-15 55.9 0.5 6.8e-14 52.0 0.0 2.6 2 1 1 3 3 3 1 Elongation factor TS POT1PC PF16686.5 CCF49568.1 - 6.8e-21 74.8 0.0 3.7e-18 65.9 0.0 2.5 2 1 0 2 2 2 2 ssDNA-binding domain of telomere protection protein POT1 PF02765.17 CCF49568.1 - 6.8e-11 42.2 0.0 1.5e-10 41.1 0.0 1.5 1 0 0 1 1 1 1 Telomeric single stranded DNA binding POT1/CDC13 DZR PF12773.7 CCF49568.1 - 0.0095 15.9 0.6 0.027 14.5 0.6 1.7 1 0 0 1 1 1 1 Double zinc ribbon zinc_ribbon_15 PF17032.5 CCF49568.1 - 0.051 14.3 0.2 0.11 13.2 0.2 1.6 1 0 0 1 1 1 0 zinc-ribbon family REPA_OB_2 PF16900.5 CCF49568.1 - 0.064 13.2 0.1 0.39 10.7 0.0 2.3 2 0 0 2 2 2 0 Replication protein A OB domain tRNA_anti-codon PF01336.25 CCF49568.1 - 0.079 13.0 0.1 3.2 7.8 0.0 3.3 4 0 0 4 4 4 0 OB-fold nucleic acid binding domain zf-4CXXC_R1 PF10497.9 CCF49569.1 - 4.3e-07 30.1 12.5 3.7e-06 27.1 12.5 2.6 1 1 0 1 1 1 1 Zinc-finger domain of monoamine-oxidase A repressor R1 MAGP PF05507.11 CCF49569.1 - 1.5 9.3 4.7 0.28 11.6 0.4 2.0 2 0 0 2 2 2 0 Microfibril-associated glycoprotein (MAGP) Hamartin PF04388.12 CCF49570.1 - 7.2e-14 51.4 10.6 7.2e-14 51.4 10.6 3.9 2 1 0 2 2 2 1 Hamartin protein HALZ PF02183.18 CCF49570.1 - 0.0007 19.8 5.0 0.18 12.0 0.3 4.3 4 0 0 4 4 4 2 Homeobox associated leucine zipper CENP-F_leu_zip PF10473.9 CCF49570.1 - 0.056 13.5 32.2 0.2 11.7 5.1 3.7 1 1 2 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 BLOC1_2 PF10046.9 CCF49570.1 - 0.057 13.7 4.9 0.19 12.0 2.3 3.0 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 bZIP_1 PF00170.21 CCF49570.1 - 0.24 11.5 13.6 2.7 8.1 0.0 4.7 5 0 0 5 5 5 0 bZIP transcription factor DUF1664 PF07889.12 CCF49570.1 - 0.39 10.8 7.7 8.1 6.5 1.4 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) FAM76 PF16046.5 CCF49570.1 - 0.7 9.2 6.9 1.6 8.0 6.9 1.7 1 1 0 1 1 1 0 FAM76 protein GldM_N PF12081.8 CCF49570.1 - 1.1 9.3 6.3 0.4 10.8 2.9 2.0 2 0 0 2 2 2 0 GldM N-terminal domain Fungal_TACC PF12709.7 CCF49570.1 - 1.4 9.4 12.7 4.3 7.9 0.7 4.6 5 0 0 5 5 4 0 Fungal Transforming acidic coiled-coil (TACC) proteins Stm1_N PF09598.10 CCF49570.1 - 2.2 9.2 7.1 13 6.7 0.6 3.2 2 0 0 2 2 2 0 Stm1 FTA4 PF13093.6 CCF49570.1 - 9.3 6.1 14.2 66 3.3 14.2 2.4 1 1 0 1 1 1 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 Spc7 PF08317.11 CCF49570.1 - 9.4 5.0 27.2 1.2 8.0 12.7 2.7 2 1 0 3 3 3 0 Spc7 kinetochore protein Pyridoxal_deC PF00282.19 CCF49571.1 - 1.7e-20 73.1 0.0 3.3e-20 72.2 0.0 1.4 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.19 CCF49571.1 - 3.4e-09 36.2 0.0 6.2e-09 35.3 0.0 1.5 1 1 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 CCF49571.1 - 0.00017 21.0 0.1 0.00035 20.0 0.0 1.5 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Dicistro_VP4 PF11492.8 CCF49571.1 - 0.0065 16.4 0.2 1.6 8.7 0.1 3.1 2 0 0 2 2 2 1 Cricket paralysis virus, VP4 Cys_Met_Meta_PP PF01053.20 CCF49571.1 - 0.011 14.3 0.0 0.017 13.7 0.0 1.2 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme Aldo_ket_red PF00248.21 CCF49572.1 - 8.9e-35 120.3 0.0 3.9e-32 111.6 0.0 2.0 1 1 1 2 2 2 2 Aldo/keto reductase family ERp29_N PF07912.13 CCF49572.1 - 0.18 12.0 0.0 0.44 10.7 0.0 1.6 2 0 0 2 2 2 0 ERp29, N-terminal domain tRNA-synt_2 PF00152.20 CCF49573.1 - 4.6e-75 252.6 0.0 5.9e-75 252.3 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 CCF49573.1 - 8.1e-12 45.0 0.0 1.8e-11 43.8 0.0 1.6 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 CCF49573.1 - 4.1e-08 33.0 0.0 0.00013 21.5 0.0 2.4 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) Ribosomal_60s PF00428.19 CCF49573.1 - 0.83 10.3 15.7 3.9 8.1 9.3 2.5 2 0 0 2 2 2 0 60s Acidic ribosomal protein Sugar_tr PF00083.24 CCF49574.1 - 1.2e-33 116.7 22.0 4.9e-26 91.6 4.8 2.9 2 1 1 3 3 3 2 Sugar (and other) transporter MFS_1 PF07690.16 CCF49574.1 - 1.1e-25 90.3 26.2 2.4e-25 89.2 26.1 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily MFS_4 PF06779.14 CCF49574.1 - 0.0019 17.6 3.9 0.0019 17.6 3.9 2.6 1 1 2 3 3 3 2 Uncharacterised MFS-type transporter YbfB G-alpha PF00503.20 CCF49575.1 - 5.9e-122 407.2 0.6 6.8e-122 407.0 0.6 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 CCF49575.1 - 3.3e-17 62.5 0.4 5.9e-12 45.4 0.1 2.5 2 0 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 CCF49575.1 - 1.6e-05 24.4 5.9 7.6e-05 22.2 0.4 2.6 2 2 0 2 2 2 1 Gtr1/RagA G protein conserved region Roc PF08477.13 CCF49575.1 - 0.00026 21.2 0.2 0.96 9.7 0.0 2.6 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase zf-CHC2 PF01807.20 CCF49575.1 - 0.0011 18.8 0.0 0.0039 17.0 0.0 1.9 2 0 0 2 2 2 1 CHC2 zinc finger MMR_HSR1 PF01926.23 CCF49575.1 - 0.0094 16.0 0.0 0.81 9.8 0.0 2.4 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_29 PF13555.6 CCF49575.1 - 0.014 15.2 0.1 0.066 13.0 0.2 2.1 1 1 1 2 2 2 0 P-loop containing region of AAA domain NB-ARC PF00931.22 CCF49575.1 - 0.024 13.8 0.0 0.037 13.2 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain MCM PF00493.23 CCF49575.1 - 0.079 12.0 0.2 0.16 11.0 0.0 1.6 2 0 0 2 2 2 0 MCM P-loop domain GTP_EFTU PF00009.27 CCF49575.1 - 0.081 12.4 0.1 3 7.3 0.1 2.3 2 1 0 2 2 2 0 Elongation factor Tu GTP binding domain FtsK_SpoIIIE PF01580.18 CCF49575.1 - 0.1 11.9 0.0 0.22 10.8 0.0 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family Presenilin PF01080.17 CCF49576.1 - 9.5 4.9 6.5 10 4.7 6.5 1.0 1 0 0 1 1 1 0 Presenilin tRNA-synt_1c PF00749.21 CCF49577.1 - 1.6e-107 359.0 0.0 3e-107 358.2 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA_synt_1c_R1 PF04558.15 CCF49577.1 - 8.9e-45 152.6 0.0 1.5e-44 151.8 0.0 1.4 1 0 0 1 1 1 1 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1 tRNA-synt_1c_C PF03950.18 CCF49577.1 - 1.5e-32 112.9 0.0 3.4e-32 111.7 0.0 1.6 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain tRNA_synt_1c_R2 PF04557.15 CCF49577.1 - 1.4e-05 25.9 1.8 1.4e-05 25.9 1.8 3.4 3 0 0 3 3 3 1 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 FBA PF04300.13 CCF49577.1 - 0.039 13.6 0.0 15 5.2 0.0 3.2 3 0 0 3 3 3 0 F-box associated region Methyltr_RsmB-F PF01189.17 CCF49578.1 - 2.2e-36 125.4 0.0 2.1e-33 115.7 0.0 2.7 2 1 0 2 2 2 2 16S rRNA methyltransferase RsmB/F Pribosyltran PF00156.27 CCF49578.1 - 8.2e-13 48.2 0.1 1.7e-12 47.2 0.1 1.5 1 0 0 1 1 1 1 Phosphoribosyl transferase domain HHH_4 PF14490.6 CCF49578.1 - 0.036 14.1 0.1 0.083 12.9 0.1 1.6 1 0 0 1 1 1 0 Helix-hairpin-helix containing domain FtsJ PF01728.19 CCF49578.1 - 0.061 13.4 0.0 0.35 11.0 0.0 2.2 2 0 0 2 2 2 0 FtsJ-like methyltransferase CDC73_C PF05179.14 CCF49579.1 - 3.4e-53 179.6 0.0 5.8e-53 178.8 0.0 1.4 1 0 0 1 1 1 1 RNA pol II accessory factor, Cdc73 family, C-terminal CDC73_N PF16050.5 CCF49579.1 - 5.7e-06 25.9 1.2 1.1e-05 24.9 0.0 1.9 1 1 1 2 2 2 1 Paf1 complex subunit CDC73 N-terminal CAP_N PF01213.19 CCF49579.1 - 0.0038 16.8 8.5 0.007 15.9 8.5 1.4 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) N terminal Spt20 PF12090.8 CCF49579.1 - 0.012 15.2 4.9 0.019 14.6 4.9 1.2 1 0 0 1 1 1 0 Spt20 family Tim17 PF02466.19 CCF49579.1 - 0.023 15.0 1.8 4.5 7.7 0.1 2.7 2 0 0 2 2 2 0 Tim17/Tim22/Tim23/Pmp24 family CCDC53 PF10152.9 CCF49579.1 - 0.03 14.7 1.4 0.056 13.9 1.4 1.5 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex TFIIA PF03153.13 CCF49579.1 - 0.038 14.0 3.8 0.058 13.4 3.8 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Dscam_C PF12355.8 CCF49579.1 - 0.055 14.4 0.8 0.14 13.1 0.8 1.6 1 0 0 1 1 1 0 Down syndrome cell adhesion molecule C terminal ATP11 PF06644.11 CCF49579.1 - 0.078 12.8 1.6 0.13 12.1 1.6 1.2 1 0 0 1 1 1 0 ATP11 protein RBM39linker PF15519.6 CCF49579.1 - 0.24 12.5 2.8 0.66 11.1 1.8 2.2 2 0 0 2 2 2 0 linker between RRM2 and RRM3 domains in RBM39 protein Lsr2 PF11774.8 CCF49579.1 - 0.4 10.8 4.8 0.31 11.2 0.5 2.5 3 0 0 3 3 2 0 Lsr2 Ost5 PF05251.12 CCF49581.1 - 2.9e-20 72.3 7.3 3.5e-20 72.1 7.3 1.1 1 0 0 1 1 1 1 Oligosaccharyltransferase subunit 5 PEPCK_ATP PF01293.20 CCF49582.1 - 7.1e-222 737.1 0.0 8.4e-222 736.9 0.0 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase AAA_33 PF13671.6 CCF49582.1 - 0.15 12.2 0.0 0.3 11.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain AMP-binding PF00501.28 CCF49583.1 - 4.7e-43 147.3 0.0 6.6e-43 146.9 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme ACAS_N PF16177.5 CCF49583.1 - 2.1e-07 30.8 0.5 2.1e-07 30.8 0.5 2.1 2 0 0 2 2 2 1 Acetyl-coenzyme A synthetase N-terminus AMP-binding_C PF13193.6 CCF49583.1 - 0.0017 19.3 0.0 0.004 18.1 0.0 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Na_Ca_ex PF01699.24 CCF49584.1 - 4.4e-36 124.1 50.7 7.8e-19 68.1 21.1 3.0 2 1 1 3 3 3 2 Sodium/calcium exchanger protein DUF1385 PF07136.11 CCF49584.1 - 0.13 11.6 0.1 0.13 11.6 0.1 3.2 2 2 1 4 4 4 0 Protein of unknown function (DUF1385) FSAP_sig_propep PF03032.15 CCF49584.1 - 1.8 8.7 4.1 2.7 8.1 0.4 2.8 2 0 0 2 2 2 0 Frog skin active peptide family signal and propeptide DUF3684 PF12449.8 CCF49585.1 - 0 1220.7 0.0 0 1220.4 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3684) MPC PF03650.13 CCF49586.1 - 3e-36 123.9 0.1 3.5e-36 123.7 0.1 1.0 1 0 0 1 1 1 1 Mitochondrial pyruvate carriers Zn_clus PF00172.18 CCF49587.1 - 4.4e-08 33.1 11.5 9.2e-08 32.1 11.5 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 CCF49587.1 - 0.02 14.0 0.8 0.18 10.8 0.2 2.8 2 1 0 2 2 2 0 Fungal specific transcription factor domain Ribosomal_S2 PF00318.20 CCF49588.1 - 1e-26 93.6 0.0 1.3e-12 47.4 0.0 2.2 1 1 1 2 2 2 2 Ribosomal protein S2 40S_SA_C PF16122.5 CCF49588.1 - 2.2e-07 32.1 15.7 4.5e-07 31.1 15.7 1.5 1 0 0 1 1 1 1 40S ribosomal protein SA C-terminus MUG113 PF13455.6 CCF49589.1 - 1.4e-16 60.9 0.0 3.7e-16 59.6 0.0 1.8 1 0 0 1 1 1 1 Meiotically up-regulated gene 113 T5orf172 PF10544.9 CCF49589.1 - 9.2e-14 51.8 0.2 5.7e-13 49.3 0.0 2.3 2 0 0 2 2 2 1 T5orf172 domain Ribosomal_S5 PF00333.20 CCF49590.1 - 3.5e-28 97.4 1.6 6.7e-28 96.5 0.7 1.9 2 0 0 2 2 2 1 Ribosomal protein S5, N-terminal domain Ribosomal_S5_C PF03719.15 CCF49590.1 - 7.7e-23 79.7 0.0 1.5e-22 78.8 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain F1F0-ATPsyn_F PF10791.9 CCF49591.1 - 4.7e-30 103.9 0.0 5.6e-30 103.7 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial F1-F0 ATP synthase subunit F of fungi IMS PF00817.20 CCF49592.1 - 2.7e-45 154.1 0.1 4.8e-45 153.2 0.1 1.4 1 0 0 1 1 1 1 impB/mucB/samB family IMS_C PF11799.8 CCF49592.1 - 1.4e-15 58.1 3.1 2.3e-15 57.3 1.9 2.0 2 0 0 2 2 2 1 impB/mucB/samB family C-terminal domain IMS_HHH PF11798.8 CCF49592.1 - 7.1e-06 26.1 0.0 1.9e-05 24.7 0.0 1.8 1 0 0 1 1 1 1 IMS family HHH motif RNF220 PF15926.5 CCF49592.1 - 0.0041 16.8 1.8 0.011 15.4 1.8 1.7 1 1 0 1 1 1 1 E3 ubiquitin-protein ligase RNF220 Sgf11 PF08209.11 CCF49592.1 - 0.086 12.4 0.2 0.26 10.9 0.2 1.8 1 1 0 1 1 1 0 Sgf11 (transcriptional regulation protein) Enkurin PF13864.6 CCF49592.1 - 0.21 12.0 1.6 1.1 9.7 0.1 2.7 2 0 0 2 2 2 0 Calmodulin-binding zf-Di19 PF05605.12 CCF49592.1 - 0.22 11.9 0.3 0.76 10.1 0.3 1.9 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding UIM PF02809.20 CCF49592.1 - 0.4 10.7 4.2 0.16 12.0 1.3 2.0 2 0 0 2 2 2 0 Ubiquitin interaction motif Peptidase_C54 PF03416.19 CCF49593.1 - 2e-102 342.3 0.0 2.9e-102 341.8 0.0 1.2 1 0 0 1 1 1 1 Peptidase family C54 NAP PF00956.18 CCF49594.1 - 3.5e-97 324.8 4.2 5.4e-97 324.2 4.2 1.3 1 0 0 1 1 1 1 Nucleosome assembly protein (NAP) Cwf_Cwc_15 PF04889.12 CCF49594.1 - 0.56 9.9 22.3 0.57 9.9 14.8 2.4 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein zf-C2H2 PF00096.26 CCF49595.1 - 4.6e-12 45.7 16.8 0.00064 20.0 0.2 3.9 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CCF49595.1 - 1.4e-08 34.9 14.0 0.0054 17.5 0.7 3.8 3 0 0 3 3 3 3 C2H2-type zinc finger zf-H2C2_2 PF13465.6 CCF49595.1 - 4.2e-08 33.3 11.4 0.0017 18.7 0.1 3.3 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_6 PF13912.6 CCF49595.1 - 1e-05 25.4 7.2 0.0025 17.8 0.0 3.3 3 0 0 3 3 3 2 C2H2-type zinc finger DUF1390 PF07150.11 CCF49595.1 - 0.059 13.1 1.0 0.11 12.2 1.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1390) EPL1 PF10513.9 CCF49595.1 - 0.14 12.6 6.4 0.4 11.0 6.4 1.8 1 0 0 1 1 1 0 Enhancer of polycomb-like Presenilin PF01080.17 CCF49595.1 - 0.26 10.0 7.7 0.5 9.1 7.7 1.4 1 0 0 1 1 1 0 Presenilin zf-C2H2_11 PF16622.5 CCF49595.1 - 0.39 10.5 3.7 1.3 8.9 0.2 2.6 2 0 0 2 2 2 0 zinc-finger C2H2-type API5 PF05918.11 CCF49595.1 - 0.86 8.3 9.9 1.4 7.6 9.9 1.2 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) SpoIIP PF07454.11 CCF49595.1 - 0.91 8.9 8.2 1.9 7.9 8.2 1.4 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) eIF-3_zeta PF05091.12 CCF49595.1 - 1.4 7.8 16.4 2.1 7.2 16.4 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Band_3_cyto PF07565.13 CCF49595.1 - 1.6 8.4 6.5 3.6 7.3 6.5 1.5 1 0 0 1 1 1 0 Band 3 cytoplasmic domain AIF_C PF14721.6 CCF49595.1 - 2.2 8.7 5.6 8.7 6.7 5.6 2.0 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Spt20 PF12090.8 CCF49595.1 - 3.3 7.3 39.4 11 5.6 39.4 1.9 1 0 0 1 1 1 0 Spt20 family DUF4457 PF14652.6 CCF49595.1 - 3.9 6.6 8.2 6.3 5.9 8.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4457) CLN3 PF02487.17 CCF49595.1 - 4.5 6.2 7.2 7 5.6 7.2 1.2 1 0 0 1 1 1 0 CLN3 protein RR_TM4-6 PF06459.12 CCF49595.1 - 4.5 7.0 9.0 5.3 6.8 7.1 1.9 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 V_ATPase_I PF01496.19 CCF49595.1 - 5.8 4.7 9.1 8.2 4.2 9.1 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF1980 PF09323.10 CCF49595.1 - 8.7 6.2 7.4 21 4.9 7.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) Acetyltransf_7 PF13508.7 CCF49597.1 - 0.00086 19.7 0.0 0.0021 18.5 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CCF49597.1 - 0.0015 18.7 0.1 0.042 14.1 0.0 2.3 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CCF49597.1 - 0.018 15.0 0.3 0.13 12.2 0.0 2.3 3 0 0 3 3 3 0 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 CCF49597.1 - 0.056 13.5 0.1 0.11 12.6 0.1 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Ribosomal_L39 PF00832.20 CCF49598.1 - 2.3e-22 78.4 11.4 2.6e-22 78.1 11.4 1.1 1 0 0 1 1 1 1 Ribosomal L39 protein Nmad3 PF18754.1 CCF49598.1 - 0.025 14.2 0.4 0.025 14.2 0.4 1.0 1 0 0 1 1 1 0 Nucleotide modification associated domain 3 adh_short_C2 PF13561.6 CCF49599.1 - 1.7e-48 165.3 0.7 2.1e-48 164.9 0.7 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCF49599.1 - 4.5e-35 120.9 0.0 5.8e-35 120.5 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CCF49599.1 - 7.3e-10 39.0 0.0 1e-09 38.6 0.0 1.2 1 0 0 1 1 1 1 KR domain His_biosynth PF00977.21 CCF49599.1 - 0.003 17.1 0.0 0.0078 15.7 0.0 1.7 1 1 0 1 1 1 1 Histidine biosynthesis protein Cbl_N3 PF02762.14 CCF49599.1 - 0.12 12.2 0.1 0.25 11.2 0.1 1.5 1 0 0 1 1 1 0 CBL proto-oncogene N-terminus, SH2-like domain Ku PF02735.16 CCF49600.1 - 9.6e-44 149.5 0.0 1.5e-43 148.9 0.0 1.3 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain Ku_N PF03731.15 CCF49600.1 - 4.1e-16 59.4 0.0 1.8e-15 57.3 0.0 2.1 2 1 0 2 2 2 1 Ku70/Ku80 N-terminal alpha/beta domain Ku_C PF03730.14 CCF49600.1 - 3.8e-14 53.1 0.1 3.8e-14 53.1 0.1 2.0 2 0 0 2 2 2 1 Ku70/Ku80 C-terminal arm SAP PF02037.27 CCF49600.1 - 6.2e-06 25.8 0.0 1.2e-05 24.9 0.0 1.5 1 0 0 1 1 1 1 SAP domain VWA_2 PF13519.6 CCF49600.1 - 0.054 14.1 0.0 2 9.1 0.0 3.0 2 1 0 2 2 2 0 von Willebrand factor type A domain Abhydrolase_3 PF07859.13 CCF49601.1 - 3.8e-27 95.5 0.0 4.9e-27 95.2 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CCF49601.1 - 0.0022 18.6 0.2 0.005 17.5 0.1 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CCF49601.1 - 0.015 14.5 0.0 5.3 6.2 0.0 2.3 2 0 0 2 2 2 0 Serine aminopeptidase, S33 BAAT_C PF08840.11 CCF49601.1 - 0.036 14.0 0.0 0.42 10.5 0.0 2.5 2 1 0 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal LIDHydrolase PF10230.9 CCF49601.1 - 0.069 12.7 0.0 0.12 11.9 0.0 1.4 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase Thioesterase PF00975.20 CCF49601.1 - 0.084 13.0 0.0 0.13 12.3 0.0 1.2 1 0 0 1 1 1 0 Thioesterase domain COesterase PF00135.28 CCF49601.1 - 0.16 10.8 0.1 1.2 7.9 0.1 1.9 1 1 0 1 1 1 0 Carboxylesterase family Peptidase_S15 PF02129.18 CCF49601.1 - 0.17 11.4 0.0 0.28 10.7 0.0 1.2 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) Glyco_transf_90 PF05686.12 CCF49602.1 - 3.1e-16 59.3 0.0 1.1e-15 57.5 0.0 1.7 1 1 0 1 1 1 1 Glycosyl transferase family 90 RabGAP-TBC PF00566.18 CCF49603.1 - 3.9e-49 167.2 0.0 3.9e-49 167.2 0.0 2.1 2 0 0 2 2 2 1 Rab-GTPase-TBC domain SH3_1 PF00018.28 CCF49603.1 - 0.0048 16.5 0.0 0.0098 15.5 0.0 1.5 1 0 0 1 1 1 1 SH3 domain Hydin_ADK PF17213.3 CCF49603.1 - 0.087 13.1 5.9 0.39 11.0 5.9 2.2 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain SH3_2 PF07653.17 CCF49603.1 - 0.15 11.8 0.0 0.32 10.7 0.0 1.4 1 0 0 1 1 1 0 Variant SH3 domain GREB1 PF15782.5 CCF49603.1 - 0.15 9.1 10.0 0.25 8.4 10.0 1.4 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Activator_LAG-3 PF11498.8 CCF49603.1 - 1 8.3 28.2 2.4 7.0 28.2 1.6 1 0 0 1 1 1 0 Transcriptional activator LAG-3 DUF3464 PF11947.8 CCF49603.1 - 9.2 6.0 8.0 23 4.7 8.0 1.6 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 Cyclin_C_2 PF16899.5 CCF49604.1 - 1.2e-13 51.3 0.2 2e-11 44.2 0.1 2.6 2 1 0 2 2 2 1 Cyclin C-terminal domain Cyclin_N PF00134.23 CCF49604.1 - 6.4e-07 29.2 0.0 1.1e-06 28.4 0.0 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain TFIIB PF00382.19 CCF49604.1 - 0.00077 19.5 0.0 0.0022 18.0 0.0 1.8 1 0 0 1 1 1 1 Transcription factor TFIIB repeat SRP-alpha_N PF04086.13 CCF49604.1 - 1.2 9.0 11.9 1.9 8.3 11.9 1.3 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Mannosyl_trans3 PF11051.8 CCF49605.1 - 6e-40 137.3 0.0 1.1e-39 136.4 0.0 1.4 1 0 0 1 1 1 1 Mannosyltransferase putative Mannosyl_trans3 PF11051.8 CCF49606.1 - 3e-24 85.8 0.0 4.9e-24 85.1 0.0 1.3 1 0 0 1 1 1 1 Mannosyltransferase putative EB PF01683.18 CCF49607.1 - 1.2e-06 28.7 71.1 0.007 16.6 10.7 6.7 1 1 5 6 6 6 5 EB module Dickkopf_N PF04706.12 CCF49607.1 - 2.5e-06 27.9 70.0 0.046 14.2 4.7 6.3 4 3 1 5 5 5 4 Dickkopf N-terminal cysteine-rich region UPF0506 PF11703.8 CCF49607.1 - 0.097 13.1 63.5 1.6 9.1 0.6 5.5 4 2 0 4 4 4 0 UPF0506 Rep_fac-A_C PF08646.10 CCF49608.1 - 3.6e-56 189.0 5.0 8e-55 184.6 0.7 2.2 2 0 0 2 2 2 2 Replication factor-A C terminal domain REPA_OB_2 PF16900.5 CCF49608.1 - 6.3e-36 122.2 0.1 6.2e-35 119.1 0.0 2.3 2 0 0 2 2 2 1 Replication protein A OB domain Rep-A_N PF04057.12 CCF49608.1 - 6e-25 87.2 0.6 1.6e-24 85.9 0.6 1.8 1 0 0 1 1 1 1 Replication factor-A protein 1, N-terminal domain tRNA_anti-codon PF01336.25 CCF49608.1 - 1.8e-12 47.1 0.2 2.7e-10 40.1 0.0 3.1 3 0 0 3 3 3 1 OB-fold nucleic acid binding domain DUF223 PF02721.14 CCF49608.1 - 0.00052 20.3 0.3 0.095 13.0 0.2 2.5 2 0 0 2 2 2 1 Domain of unknown function DUF223 CDC24_OB3 PF17244.2 CCF49608.1 - 0.0082 15.9 0.1 0.099 12.3 0.0 2.3 2 0 0 2 2 2 1 Cell division control protein 24, OB domain 3 DUF5521 PF17659.1 CCF49608.1 - 0.071 11.0 0.2 0.21 9.4 0.0 1.8 2 0 0 2 2 2 0 Family of unknown function (DUF5521) Nup96 PF12110.8 CCF49610.1 - 2.2e-95 319.1 0.0 3.4e-95 318.5 0.0 1.3 1 0 0 1 1 1 1 Nuclear protein 96 Nucleoporin2 PF04096.14 CCF49610.1 - 2.6e-55 186.6 0.0 4.2e-55 186.0 0.0 1.3 1 0 0 1 1 1 1 Nucleoporin autopeptidase Nucleoporin_FG PF13634.6 CCF49610.1 - 1.3e-16 61.2 400.3 0.0001 23.1 33.3 13.0 4 3 11 15 15 15 8 Nucleoporin FG repeat region zf-C2H2_jaz PF12171.8 CCF49611.1 - 1.5e-05 25.2 0.0 2.4e-05 24.5 0.0 1.3 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 CCF49611.1 - 3.1e-05 24.2 0.1 5e-05 23.5 0.1 1.4 1 0 0 1 1 1 1 Zinc-finger of C2H2 type SNRNP27 PF08648.12 CCF49611.1 - 0.0033 17.4 0.4 0.0033 17.4 0.4 2.1 3 0 0 3 3 3 1 U4/U6.U5 small nuclear ribonucleoproteins RSS_P20 PF11757.8 CCF49611.1 - 0.076 13.5 0.8 0.13 12.7 0.8 1.4 1 0 0 1 1 1 0 Suppressor of RNA silencing P21-like N-terminal domain DUF3340 PF11818.8 CCF49611.1 - 1 9.5 11.7 4.8 7.3 5.4 2.2 2 0 0 2 2 2 0 C-terminal domain of tail specific protease (DUF3340) tRNA-synt_1 PF00133.22 CCF49612.1 - 2.5e-228 759.3 0.0 3.5e-228 758.7 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 CCF49612.1 - 1.4e-22 80.3 0.0 2.8e-22 79.3 0.0 1.5 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 CCF49612.1 - 1.2e-14 53.8 1.1 5.1e-05 22.2 0.1 4.0 3 1 0 3 3 3 3 tRNA synthetases class I (M) tRNA-synt_1e PF01406.19 CCF49612.1 - 0.0013 18.2 0.0 0.0035 16.7 0.0 1.8 2 0 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain Phosducin PF02114.16 CCF49613.1 - 6.2e-19 68.0 1.1 4.5e-08 32.4 0.0 3.1 3 0 0 3 3 3 3 Phosducin CamS PF07537.11 CCF49613.1 - 0.0073 15.5 0.2 2.8 7.0 0.0 2.1 2 0 0 2 2 2 2 CamS sex pheromone cAM373 precursor GATase_5 PF13507.6 CCF49614.1 - 7.9e-95 316.9 0.0 1.1e-94 316.4 0.0 1.2 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain AIRS_C PF02769.22 CCF49614.1 - 1.2e-40 139.2 1.9 6.3e-25 88.1 0.1 2.9 3 1 0 3 3 3 2 AIR synthase related protein, C-terminal domain FGAR-AT_N PF18076.1 CCF49614.1 - 3.5e-34 117.2 0.0 6.7e-34 116.3 0.0 1.5 1 0 0 1 1 1 1 Formylglycinamide ribonucleotide amidotransferase N-terminal FGAR-AT_linker PF18072.1 CCF49614.1 - 4.4e-22 78.4 0.0 1.2e-21 77.0 0.0 1.8 1 0 0 1 1 1 1 Formylglycinamide ribonucleotide amidotransferase linker domain AIRS PF00586.24 CCF49614.1 - 0.065 13.9 0.0 2.7 8.7 0.0 2.9 2 0 0 2 2 2 0 AIR synthase related protein, N-terminal domain zf-CCCH PF00642.24 CCF49615.1 - 1.6e-09 37.4 2.9 3.4e-09 36.4 2.9 1.6 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-C3HC4_3 PF13920.6 CCF49615.1 - 1.2e-08 34.7 5.3 2.1e-08 33.9 5.3 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CCF49615.1 - 1.8e-07 31.0 8.6 2.9e-07 30.3 8.6 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 CCF49615.1 - 3.3e-06 26.8 7.8 6.4e-06 25.9 7.8 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CCF49615.1 - 3.8e-06 26.8 8.2 7.7e-06 25.8 8.2 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 CCF49615.1 - 2.7e-05 23.9 8.4 5e-05 23.1 8.4 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CCF49615.1 - 2.9e-05 24.3 7.2 5.8e-05 23.3 7.2 1.5 1 0 0 1 1 1 1 Ring finger domain zf_CCCH_4 PF18345.1 CCF49615.1 - 3e-05 23.9 4.4 6.5e-05 22.8 4.4 1.6 1 0 0 1 1 1 1 Zinc finger domain zf-C3HC4_4 PF15227.6 CCF49615.1 - 0.00027 21.0 6.6 0.00061 19.9 6.6 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_10 PF16685.5 CCF49615.1 - 0.00032 20.8 2.7 0.00074 19.6 2.7 1.6 1 0 0 1 1 1 1 zinc RING finger of MSL2 zf-CCCH_4 PF18044.1 CCF49615.1 - 0.003 17.3 3.3 0.0064 16.3 3.3 1.6 1 0 0 1 1 1 1 CCCH-type zinc finger Prok-RING_4 PF14447.6 CCF49615.1 - 0.0091 15.8 6.1 0.017 15.0 6.1 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zinc-ribbon_6 PF10005.9 CCF49615.1 - 0.027 15.1 0.9 0.073 13.8 0.9 1.7 1 0 0 1 1 1 0 zinc-ribbon domain zf-Nse PF11789.8 CCF49615.1 - 0.038 13.8 3.7 0.073 12.9 3.7 1.4 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-RanBP PF00641.18 CCF49615.1 - 0.37 10.2 4.8 1.4 8.4 4.8 1.9 1 0 0 1 1 1 0 Zn-finger in Ran binding protein and others zf-RING_6 PF14835.6 CCF49615.1 - 1.4 8.9 4.2 2.8 7.9 4.2 1.5 1 0 0 1 1 1 0 zf-RING of BARD1-type protein Macoilin PF09726.9 CCF49615.1 - 9.7 4.6 7.2 13 4.2 7.2 1.3 1 0 0 1 1 1 0 Macoilin family K_oxygenase PF13434.6 CCF49616.1 - 3.4e-83 279.6 0.0 9.8e-82 274.8 0.0 2.5 1 1 0 1 1 1 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 CCF49616.1 - 0.00088 19.3 0.1 0.028 14.4 0.0 2.8 3 0 0 3 3 3 1 FAD-NAD(P)-binding AMP-binding PF00501.28 CCF49617.1 - 2.4e-215 715.0 0.0 3.4e-78 263.1 0.0 3.4 3 0 0 3 3 3 3 AMP-binding enzyme Condensation PF00668.20 CCF49617.1 - 1e-115 387.1 0.0 8.5e-33 113.7 0.0 4.2 4 0 0 4 4 4 4 Condensation domain PP-binding PF00550.25 CCF49617.1 - 1.2e-34 118.4 4.2 1.1e-08 35.3 0.0 5.1 4 0 0 4 4 4 4 Phosphopantetheine attachment site AMP-binding_C PF13193.6 CCF49617.1 - 4.2e-11 43.7 0.3 0.003 18.5 0.1 4.0 3 0 0 3 3 3 3 AMP-binding enzyme C-terminal domain Transferase PF02458.15 CCF49617.1 - 0.00093 18.0 0.3 2.8 6.5 0.0 3.6 4 0 0 4 4 4 2 Transferase family ANTH PF07651.16 CCF49618.1 - 2.5e-49 167.7 0.0 3.7e-49 167.2 0.0 1.2 1 0 0 1 1 1 1 ANTH domain ENTH PF01417.20 CCF49618.1 - 3.8e-05 23.7 0.0 6.9e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 ENTH domain Bromodomain PF00439.25 CCF49619.1 - 7e-26 90.1 0.1 1.4e-25 89.2 0.1 1.5 1 0 0 1 1 1 1 Bromodomain Acetyltransf_1 PF00583.25 CCF49619.1 - 8.9e-08 32.4 0.0 1.7e-07 31.5 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CCF49619.1 - 5.8e-06 26.3 0.1 1.1e-05 25.3 0.1 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CCF49619.1 - 0.00024 21.4 0.1 0.00046 20.6 0.1 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain BC10 PF06726.12 CCF49620.1 - 3.3e-17 62.5 7.0 6.6e-17 61.5 7.0 1.5 1 0 0 1 1 1 1 Bladder cancer-related protein BC10 SNF2_N PF00176.23 CCF49621.1 - 1.3e-52 178.7 0.0 2.3e-52 177.9 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 CCF49621.1 - 4.3e-15 56.0 0.0 1.3e-14 54.5 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 CCF49621.1 - 1.1e-07 32.0 0.0 3e-07 30.6 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 CCF49621.1 - 1.4e-07 31.0 0.0 3.2e-07 29.8 0.0 1.5 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase HHH_3 PF12836.7 CCF49621.1 - 0.11 12.8 0.0 0.34 11.2 0.0 1.8 1 0 0 1 1 1 0 Helix-hairpin-helix motif 2-Hacid_dh_C PF02826.19 CCF49622.1 - 1.3e-46 158.2 0.0 1.9e-46 157.7 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 CCF49622.1 - 8.1e-22 77.3 0.0 1.1e-21 76.9 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain Shikimate_DH PF01488.20 CCF49622.1 - 0.095 12.8 0.0 2.3 8.3 0.0 2.2 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase NAD_binding_2 PF03446.15 CCF49622.1 - 0.096 12.9 0.0 0.83 9.8 0.0 2.1 2 0 0 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase Pterin_bind PF00809.22 CCF49624.1 - 2.8e-77 259.7 1.8 2.7e-65 220.5 0.5 2.7 2 0 0 2 2 2 2 Pterin binding enzyme FolB PF02152.18 CCF49624.1 - 1.4e-49 167.3 4.5 6.6e-24 84.6 0.9 2.5 2 0 0 2 2 2 2 Dihydroneopterin aldolase HPPK PF01288.20 CCF49624.1 - 2.3e-35 121.5 0.0 5e-35 120.4 0.0 1.6 1 0 0 1 1 1 1 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) MafB PF06255.13 CCF49624.1 - 0.39 10.1 4.2 0.16 11.4 1.2 1.8 2 0 0 2 2 2 0 Neisseria toxin MafB PIN_4 PF13638.6 CCF49625.1 - 1.2e-16 61.2 0.4 5.3e-16 59.1 0.0 2.5 2 1 0 2 2 2 1 PIN domain EST1_DNA_bind PF10373.9 CCF49625.1 - 8.3e-13 48.4 0.6 2.4e-12 46.9 0.0 2.1 3 0 0 3 3 3 1 Est1 DNA/RNA binding domain PIN_9 PF18477.1 CCF49625.1 - 0.067 13.5 0.1 0.54 10.6 0.0 2.5 2 0 0 2 2 2 0 PIN like domain TPR_1 PF00515.28 CCF49626.1 - 7.1e-24 82.6 7.2 0.00018 21.2 0.0 7.0 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_2 PF07719.17 CCF49626.1 - 3.9e-22 76.5 9.7 0.00018 21.3 0.1 7.1 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_19 PF14559.6 CCF49626.1 - 1.2e-21 77.0 12.1 1e-06 29.2 1.1 5.4 4 1 1 5 5 5 4 Tetratricopeptide repeat TPR_9 PF13371.6 CCF49626.1 - 9.9e-20 70.5 8.2 4.4e-08 33.2 0.7 4.7 3 2 2 5 5 5 3 Tetratricopeptide repeat DnaJ PF00226.31 CCF49626.1 - 1.8e-17 63.2 0.0 7.6e-17 61.2 0.0 2.2 1 0 0 1 1 1 1 DnaJ domain TPR_8 PF13181.6 CCF49626.1 - 1.1e-15 56.4 12.7 0.0032 17.6 2.2 6.5 5 0 0 5 5 5 5 Tetratricopeptide repeat TPR_16 PF13432.6 CCF49626.1 - 2e-15 57.2 11.3 0.0018 18.9 0.8 4.8 3 1 0 4 4 4 3 Tetratricopeptide repeat TPR_14 PF13428.6 CCF49626.1 - 6.5e-13 48.3 17.4 0.015 16.0 0.0 7.6 5 3 4 9 9 7 5 Tetratricopeptide repeat TPR_11 PF13414.6 CCF49626.1 - 2.8e-11 42.9 1.5 0.0064 16.2 0.3 5.3 3 2 3 6 6 6 3 TPR repeat TPR_17 PF13431.6 CCF49626.1 - 1.2e-09 37.9 11.3 0.044 14.2 0.0 6.1 7 0 0 7 7 6 3 Tetratricopeptide repeat TPR_6 PF13174.6 CCF49626.1 - 3.1e-08 33.7 18.1 0.042 14.5 0.2 7.0 7 0 0 7 7 6 2 Tetratricopeptide repeat ANAPC3 PF12895.7 CCF49626.1 - 4.5e-08 33.2 14.6 0.0018 18.5 0.3 4.8 4 1 0 5 5 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.6 CCF49626.1 - 5.9e-07 29.7 11.4 0.021 15.1 2.6 4.4 4 1 0 4 4 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 CCF49626.1 - 9.7e-07 28.4 8.0 0.35 11.0 0.0 5.7 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_20 PF14561.6 CCF49626.1 - 1.8e-06 28.2 15.5 0.0069 16.7 0.6 5.3 5 1 0 6 6 4 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 CCF49626.1 - 3.8e-05 23.7 4.6 0.68 10.1 0.0 5.3 4 1 1 5 5 5 1 Fis1 C-terminal tetratricopeptide repeat BTAD PF03704.17 CCF49626.1 - 0.00069 20.1 7.9 0.022 15.2 0.2 3.7 3 1 0 4 4 3 1 Bacterial transcriptional activator domain NARP1 PF12569.8 CCF49626.1 - 0.00069 18.6 14.7 0.034 13.0 2.3 3.5 4 0 0 4 4 4 2 NMDA receptor-regulated protein 1 YfdX PF10938.8 CCF49626.1 - 0.0051 16.7 13.3 0.25 11.3 1.2 4.3 2 1 2 4 4 4 2 YfdX protein Spectrin PF00435.21 CCF49626.1 - 0.0051 17.3 5.4 0.18 12.3 0.9 4.1 3 2 0 3 3 3 1 Spectrin repeat PknG_TPR PF16918.5 CCF49626.1 - 0.0078 15.0 3.5 0.011 14.4 0.2 2.7 3 1 0 3 3 3 1 Protein kinase G tetratricopeptide repeat TPR_4 PF07721.14 CCF49626.1 - 0.021 15.4 8.2 20 6.2 0.1 5.1 5 0 0 5 5 4 0 Tetratricopeptide repeat HrpB1_HrpK PF09613.10 CCF49626.1 - 0.024 14.3 1.8 17 5.1 0.0 3.8 4 1 1 5 5 4 0 Bacterial type III secretion protein (HrpB1_HrpK) DUF1330 PF07045.11 CCF49626.1 - 0.028 14.7 0.5 2 8.8 0.0 3.5 4 0 0 4 4 4 0 Domain of unknown function (DUF1330) HemY_N PF07219.13 CCF49626.1 - 0.043 14.0 9.3 0.67 10.2 0.4 4.2 4 1 0 4 4 3 0 HemY protein N-terminus DUF3856 PF12968.7 CCF49626.1 - 0.063 13.4 5.3 6 6.9 0.2 3.8 3 1 0 3 3 3 0 Domain of Unknown Function (DUF3856) DUF357 PF04010.13 CCF49626.1 - 0.071 13.2 3.3 1.6 8.9 0.2 3.3 3 0 0 3 3 2 0 Protein of unknown function (DUF357) YfiO PF13525.6 CCF49626.1 - 0.5 10.1 11.1 0.34 10.6 2.2 3.5 2 1 1 3 3 3 0 Outer membrane lipoprotein TPR_21 PF09976.9 CCF49626.1 - 0.6 9.8 18.3 1 9.0 0.1 3.9 4 1 0 4 4 4 0 Tetratricopeptide repeat-like domain ANAPC5 PF12862.7 CCF49626.1 - 0.75 9.9 6.2 1.1 9.4 0.1 2.9 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 5 DUF4363 PF14276.6 CCF49626.1 - 1.5 8.9 11.9 42 4.3 0.2 5.7 5 2 1 6 6 6 0 Domain of unknown function (DUF4363) SHNi-TPR PF10516.9 CCF49626.1 - 2.4 7.7 8.7 0.19 11.2 0.3 3.0 3 0 0 3 3 3 0 SHNi-TPR Med9 PF07544.13 CCF49626.1 - 4.7 7.4 6.9 16 5.7 0.1 3.2 3 0 0 3 3 2 0 RNA polymerase II transcription mediator complex subunit 9 DUF2431 PF10354.9 CCF49628.1 - 3.2e-39 134.9 0.0 4.6e-38 131.1 0.0 2.1 1 1 0 1 1 1 1 Domain of unknown function (DUF2431) Serinc PF03348.15 CCF49629.1 - 1.4e-156 521.7 6.9 1.7e-156 521.5 6.9 1.0 1 0 0 1 1 1 1 Serine incorporator (Serinc) YtpI PF14007.6 CCF49629.1 - 6.7 6.9 14.2 0.21 11.7 3.9 3.2 3 0 0 3 3 3 0 YtpI-like protein EMP70 PF02990.16 CCF49630.1 - 3.6e-189 629.7 1.4 5.6e-189 629.1 1.4 1.3 1 0 0 1 1 1 1 Endomembrane protein 70 Sybindin PF04099.12 CCF49631.1 - 1.8e-08 34.4 0.0 2e-06 27.8 0.0 2.3 2 1 0 2 2 2 2 Sybindin-like family MDD_C PF18376.1 CCF49632.1 - 1.3e-72 243.5 0.0 1.8e-72 243.0 0.0 1.2 1 0 0 1 1 1 1 Mevalonate 5-diphosphate decarboxylase C-terminal domain GHMP_kinases_N PF00288.26 CCF49632.1 - 2.7e-07 30.7 3.2 5.6e-07 29.7 3.2 1.6 1 0 0 1 1 1 1 GHMP kinases N terminal domain UreF PF01730.16 CCF49632.1 - 0.015 15.9 0.0 0.36 11.4 0.0 2.3 1 1 1 2 2 2 0 UreF Tegument_dsDNA PF12818.7 CCF49632.1 - 0.17 11.0 0.0 0.29 10.2 0.0 1.3 1 0 0 1 1 1 0 dsDNA viral tegument protein Brix PF04427.18 CCF49633.1 - 3e-44 151.5 0.1 4e-44 151.0 0.1 1.2 1 0 0 1 1 1 1 Brix domain Nucleopor_Nup85 PF07575.13 CCF49633.1 - 0.044 12.4 0.1 0.055 12.0 0.1 1.1 1 0 0 1 1 1 0 Nup85 Nucleoporin Kazal_3 PF18434.1 CCF49635.1 - 0.056 13.2 0.4 0.11 12.3 0.4 1.5 1 0 0 1 1 1 0 Kazal-type serine protease inhibitor domain HSF_DNA-bind PF00447.17 CCF49636.1 - 1.2e-31 109.2 0.1 2.5e-31 108.1 0.1 1.6 1 0 0 1 1 1 1 HSF-type DNA-binding DUF1465 PF07323.12 CCF49636.1 - 0.021 14.7 0.3 0.16 11.8 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1465) Ets PF00178.22 CCF49636.1 - 0.093 13.2 0.0 0.2 12.1 0.0 1.5 1 0 0 1 1 1 0 Ets-domain TFIIA PF03153.13 CCF49637.1 - 5.8e-57 194.5 21.3 8.9e-36 124.8 17.0 2.0 1 1 1 2 2 2 2 Transcription factor IIA, alpha/beta subunit Tup_N PF08581.10 CCF49637.1 - 0.032 14.5 0.4 0.062 13.6 0.4 1.4 1 0 0 1 1 1 0 Tup N-terminal BUD22 PF09073.10 CCF49637.1 - 0.066 12.6 13.7 0.08 12.3 13.7 1.2 1 0 0 1 1 1 0 BUD22 SPX PF03105.19 CCF49637.1 - 0.11 12.4 7.0 0.14 12.1 7.0 1.1 1 0 0 1 1 1 0 SPX domain BNIP3 PF06553.12 CCF49637.1 - 0.26 10.9 5.4 0.36 10.5 5.4 1.2 1 0 0 1 1 1 0 BNIP3 Cwf_Cwc_15 PF04889.12 CCF49637.1 - 1 9.0 11.1 1.4 8.6 11.1 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein MSP1_C PF07462.11 CCF49637.1 - 2 7.0 4.8 2.9 6.5 4.8 1.2 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus SRP-alpha_N PF04086.13 CCF49637.1 - 6.1 6.7 18.8 7.1 6.5 17.5 1.5 1 1 1 2 2 2 0 Signal recognition particle, alpha subunit, N-terminal PWWP PF00855.17 CCF49638.1 - 4.7e-20 71.8 0.0 4.7e-20 71.8 0.0 2.4 2 1 0 2 2 2 1 PWWP domain Med26 PF08711.11 CCF49638.1 - 1.5e-06 28.2 0.0 5.9e-06 26.2 0.0 2.1 1 0 0 1 1 1 1 TFIIS helical bundle-like domain NACHT_N PF17100.5 CCF49638.1 - 1.5 8.6 6.1 2.6 7.9 6.1 1.4 1 0 0 1 1 1 0 N-terminal domain of NWD NACHT-NTPase Hid1 PF12722.7 CCF49638.1 - 1.9 6.5 12.6 2.7 6.0 12.6 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF908 PF06012.12 CCF49638.1 - 3.4 7.0 8.1 8.6 5.7 8.1 1.7 1 1 0 1 1 1 0 Domain of Unknown Function (DUF908) Ndc1_Nup PF09531.10 CCF49638.1 - 9.3 4.8 6.5 12 4.4 6.5 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Pam17 PF08566.10 CCF49639.1 - 0.099 12.5 0.0 0.2 11.5 0.0 1.4 1 0 0 1 1 1 0 Mitochondrial import protein Pam17 IL4 PF00727.18 CCF49639.1 - 0.1 12.9 0.2 0.24 11.6 0.2 1.6 1 0 0 1 1 1 0 Interleukin 4 BRE1 PF08647.11 CCF49640.1 - 9.6e-22 76.9 10.9 9.6e-22 76.9 10.9 9.0 4 3 5 9 9 9 1 BRE1 E3 ubiquitin ligase zf-C3HC4 PF00097.25 CCF49640.1 - 2.6e-06 27.2 11.6 4.4e-06 26.5 11.6 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CCF49640.1 - 3.4e-06 26.9 11.7 6.1e-06 26.1 11.7 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 CCF49640.1 - 1.2e-05 25.0 9.0 2.1e-05 24.3 9.0 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 CCF49640.1 - 3.6e-05 23.5 10.0 6e-05 22.8 10.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CCF49640.1 - 3.7e-05 23.6 6.2 7e-05 22.8 6.2 1.5 1 0 0 1 1 1 1 RING-type zinc-finger Prok-RING_4 PF14447.6 CCF49640.1 - 0.001 18.9 7.1 0.0018 18.1 7.1 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_6 PF14835.6 CCF49640.1 - 0.0019 18.1 3.0 0.0038 17.1 3.0 1.4 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-RING_2 PF13639.6 CCF49640.1 - 0.0053 17.1 9.7 0.0088 16.4 9.7 1.4 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 CCF49640.1 - 0.029 14.7 5.5 0.061 13.6 5.5 1.5 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-ribbon_3 PF13248.6 CCF49640.1 - 0.03 13.7 0.6 0.03 13.7 0.6 2.1 2 0 0 2 2 2 0 zinc-ribbon domain zf-C3HC4_5 PF17121.5 CCF49640.1 - 0.13 12.2 6.3 0.28 11.1 6.3 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DZR PF12773.7 CCF49640.1 - 1 9.5 6.8 1.9 8.6 6.8 1.4 1 0 0 1 1 1 0 Double zinc ribbon zf-C3HC4_4 PF15227.6 CCF49640.1 - 3.3 8.0 8.3 6.1 7.1 8.3 1.5 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING RNA_pol_N PF01194.17 CCF49641.1 - 3.7e-31 107.2 0.5 4.3e-31 107.0 0.5 1.1 1 0 0 1 1 1 1 RNA polymerases N / 8 kDa subunit SecY PF00344.20 CCF49642.1 - 2.4e-73 247.1 7.8 3e-73 246.8 7.8 1.1 1 0 0 1 1 1 1 SecY translocase Plug_translocon PF10559.9 CCF49642.1 - 1.9e-17 62.8 0.2 6.7e-17 61.0 0.2 2.0 1 0 0 1 1 1 1 Plug domain of Sec61p Claudin_3 PF06653.11 CCF49642.1 - 0.2 11.6 3.8 1.5 8.7 0.0 3.3 3 1 0 3 3 3 0 Tight junction protein, Claudin-like Ribosomal_L27e PF01777.18 CCF49643.1 - 1.2e-38 131.3 2.4 2e-38 130.6 2.4 1.4 1 0 0 1 1 1 1 Ribosomal L27e protein family KOW PF00467.29 CCF49643.1 - 8.1e-05 22.4 2.1 0.00011 22.1 0.6 2.0 2 0 0 2 2 2 1 KOW motif Ribosom_S12_S23 PF00164.25 CCF49644.1 - 7.1e-48 161.0 0.5 9.1e-48 160.6 0.5 1.1 1 0 0 1 1 1 1 Ribosomal protein S12/S23 Mito_carr PF00153.27 CCF49646.1 - 2.5e-11 43.3 0.1 0.0032 17.4 0.0 3.7 3 0 0 3 3 3 3 Mitochondrial carrier protein gag-asp_proteas PF13975.6 CCF49647.1 - 1.1e-08 35.5 0.1 1.5e-08 35.1 0.1 1.2 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease RVP_2 PF08284.11 CCF49647.1 - 1.1e-08 34.9 0.0 1.4e-08 34.6 0.0 1.1 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease_2 PF13650.6 CCF49647.1 - 5.3e-07 30.2 0.2 8.1e-07 29.6 0.2 1.2 1 0 0 1 1 1 1 Aspartyl protease Peptidase_A2B PF12384.8 CCF49647.1 - 0.05 13.1 0.0 0.062 12.8 0.0 1.1 1 0 0 1 1 1 0 Ty3 transposon peptidase Metallophos PF00149.28 CCF49650.1 - 2.3e-34 119.7 0.3 3e-34 119.3 0.3 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 CCF49650.1 - 0.16 12.1 0.0 0.24 11.6 0.0 1.2 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain Rax2 PF12768.7 CCF49651.1 - 4.4e-40 137.4 2.7 6.1e-38 130.4 0.0 4.6 5 2 2 7 7 7 1 Cortical protein marker for cell polarity SH3_1 PF00018.28 CCF49651.1 - 2.7e-14 52.5 0.0 6.3e-14 51.3 0.0 1.7 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 CCF49651.1 - 5.1e-12 45.5 0.1 3.9e-11 42.6 0.0 2.3 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.17 CCF49651.1 - 1.9e-06 27.4 0.0 4.2e-06 26.3 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_10 PF17902.1 CCF49651.1 - 0.011 15.8 0.0 0.04 14.0 0.0 2.0 1 0 0 1 1 1 0 SH3 domain DUF1918 PF08940.11 CCF49651.1 - 0.025 14.2 0.0 0.12 12.1 0.0 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1918) hSH3 PF14603.6 CCF49651.1 - 0.053 14.0 0.0 0.098 13.1 0.0 1.4 1 0 0 1 1 1 0 Helically-extended SH3 domain DUF5122 PF17164.4 CCF49651.1 - 0.091 13.1 22.7 0.31 11.4 0.1 7.6 8 0 0 8 8 8 0 Domain of unknown function (DUF5122) beta-propeller NCU-G1 PF15065.6 CCF49651.1 - 0.57 9.1 3.0 0.96 8.4 3.0 1.3 1 0 0 1 1 1 0 Lysosomal transcription factor, NCU-G1 HIT PF01230.23 CCF49654.1 - 2.1e-18 66.8 3.5 4.4e-18 65.8 0.7 2.0 2 0 0 2 2 2 1 HIT domain DcpS_C PF11969.8 CCF49654.1 - 1.9e-14 54.1 0.1 3.1e-14 53.4 0.1 1.3 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding CwfJ_C_1 PF04677.15 CCF49654.1 - 2.7e-06 27.3 0.0 4.1e-06 26.7 0.0 1.2 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 PIG-P PF08510.12 CCF49655.1 - 8e-32 109.7 1.2 1.1e-31 109.2 1.2 1.2 1 0 0 1 1 1 1 PIG-P CIA30 PF08547.12 CCF49655.1 - 3.3e-15 56.5 0.1 3.1e-08 33.8 0.0 2.2 2 0 0 2 2 2 2 Complex I intermediate-associated protein 30 (CIA30) DPM2 PF07297.12 CCF49655.1 - 0.0039 17.4 2.7 0.0067 16.7 2.7 1.3 1 0 0 1 1 1 1 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) DUF3729 PF12526.8 CCF49655.1 - 0.2 13.2 7.8 2.1 9.9 4.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3729) HMMR_C PF15908.5 CCF49656.1 - 0.00019 21.7 7.4 0.00019 21.7 7.4 5.2 3 1 2 5 5 5 1 Hyaluronan mediated motility receptor C-terminal DUF3450 PF11932.8 CCF49656.1 - 0.0027 17.0 4.3 0.0027 17.0 4.3 6.7 3 2 3 7 7 7 1 Protein of unknown function (DUF3450) Baculo_PEP_C PF04513.12 CCF49656.1 - 5.5 7.0 35.6 0.12 12.4 3.7 5.0 4 1 1 5 5 5 0 Baculovirus polyhedron envelope protein, PEP, C terminus Vps53_N PF04100.12 CCF49657.1 - 3.9e-88 296.0 6.3 6.9e-88 295.2 6.3 1.3 1 0 0 1 1 1 1 Vps53-like, N-terminal NBD94 PF16830.5 CCF49657.1 - 0.013 15.8 0.5 0.029 14.7 0.5 1.5 1 0 0 1 1 1 0 Nucleotide-Binding Domain 94 of RH Zw10 PF06248.13 CCF49657.1 - 0.1 11.1 4.0 0.11 11.0 2.3 1.9 2 0 0 2 2 2 0 Centromere/kinetochore Zw10 Vps54_N PF10475.9 CCF49657.1 - 0.11 11.8 6.5 0.19 11.0 6.5 1.3 1 0 0 1 1 1 0 Vacuolar-sorting protein 54, of GARP complex DUF3452 PF11934.8 CCF49657.1 - 0.14 11.7 0.4 0.88 9.1 0.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3452) Fib_alpha PF08702.10 CCF49657.1 - 0.28 11.4 6.9 0.94 9.7 6.9 1.9 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family DUF5394 PF17372.2 CCF49657.1 - 0.39 10.2 2.8 0.73 9.3 2.8 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5394) Med9 PF07544.13 CCF49657.1 - 0.64 10.2 4.3 0.74 10.0 2.6 2.1 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 PSD4 PF07631.11 CCF49657.1 - 1.6 9.3 4.8 11 6.6 0.1 3.2 3 1 0 3 3 3 0 Protein of unknown function (DUF1592) DEAD PF00270.29 CCF49658.1 - 4.1e-41 140.7 0.0 7.3e-41 139.8 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CCF49658.1 - 2e-23 82.8 0.0 7.2e-23 81.1 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DBP10CT PF08147.12 CCF49658.1 - 9.2e-22 77.1 0.1 6.5e-21 74.4 0.2 2.5 2 0 0 2 2 2 1 DBP10CT (NUC160) domain ResIII PF04851.15 CCF49658.1 - 1.1e-05 25.5 0.0 2.9e-05 24.2 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC4 PF02732.15 CCF49659.1 - 1.6e-15 57.7 0.0 2.9e-15 56.8 0.0 1.4 1 0 0 1 1 1 1 ERCC4 domain DUF1774 PF08611.10 CCF49660.1 - 5.5 7.4 11.7 0.17 12.2 1.6 3.0 2 2 1 3 3 3 0 Fungal protein of unknown function (DUF1774) Ribonuclease PF00545.20 CCF49661.1 - 4.4e-10 40.2 0.2 6.4e-10 39.6 0.2 1.2 1 0 0 1 1 1 1 ribonuclease HBD PF18534.1 CCF49662.1 - 0.029 14.5 0.1 0.044 13.9 0.1 1.2 1 0 0 1 1 1 0 Helical bundle domain Oxysterol_BP PF01237.18 CCF49663.1 - 2e-134 448.2 0.0 4.8e-134 446.9 0.0 1.6 2 0 0 2 2 2 1 Oxysterol-binding protein Ank_2 PF12796.7 CCF49663.1 - 7.1e-14 52.2 0.6 1.8e-10 41.3 0.2 3.0 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 CCF49663.1 - 1.4e-13 49.7 0.1 0.0015 18.8 0.1 3.9 3 0 0 3 3 3 3 Ankyrin repeat Ank_5 PF13857.6 CCF49663.1 - 3.6e-11 43.1 0.2 0.074 13.4 0.0 3.7 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 CCF49663.1 - 1.1e-10 41.4 0.0 0.046 14.2 0.1 3.8 3 0 0 3 3 3 3 Ankyrin repeat PH PF00169.29 CCF49663.1 - 1.5e-10 41.5 0.0 3e-10 40.6 0.0 1.5 1 0 0 1 1 1 1 PH domain Ank_4 PF13637.6 CCF49663.1 - 1.2e-09 38.5 0.4 0.0015 19.1 0.1 3.7 2 2 3 5 5 5 5 Ankyrin repeats (many copies) PH_11 PF15413.6 CCF49663.1 - 3.1e-07 30.8 0.1 1e-06 29.1 0.1 2.0 1 0 0 1 1 1 1 Pleckstrin homology domain PH_8 PF15409.6 CCF49663.1 - 1.5e-05 25.2 0.1 4.2e-05 23.7 0.1 1.8 1 0 0 1 1 1 1 Pleckstrin homology domain CR6_interact PF10147.9 CCF49663.1 - 0.93 9.2 11.4 0.039 13.7 3.7 2.4 2 0 0 2 2 2 0 Growth arrest and DNA-damage-inducible proteins-interacting protein 1 Put_Phosphatase PF06888.12 CCF49664.1 - 3.1e-50 170.7 0.0 3.6e-50 170.6 0.0 1.0 1 0 0 1 1 1 1 Putative Phosphatase HAD PF12710.7 CCF49664.1 - 2.8e-08 34.4 0.0 4.7e-08 33.7 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 CCF49664.1 - 0.0019 18.3 0.1 0.066 13.3 0.3 2.8 2 1 0 2 2 2 1 Haloacid dehalogenase-like hydrolase AP3D1 PF06375.11 CCF49665.1 - 8 6.7 11.5 0.49 10.6 6.6 1.6 2 0 0 2 2 2 0 AP-3 complex subunit delta-1 RhoGEF PF00621.20 CCF49666.1 - 2.2e-18 67.2 0.0 4.2e-18 66.2 0.0 1.4 1 0 0 1 1 1 1 RhoGEF domain CBFD_NFYB_HMF PF00808.23 CCF49667.1 - 5.1e-13 49.1 0.3 9.6e-13 48.2 0.3 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 CCF49667.1 - 1.9e-06 28.3 0.1 1.9e-06 28.3 0.1 2.8 2 1 0 2 2 1 1 Core histone H2A/H2B/H3/H4 Paf1 PF03985.13 CCF49667.1 - 0.0025 16.9 28.2 0.0035 16.4 28.2 1.4 1 0 0 1 1 1 1 Paf1 DUF2052 PF09747.9 CCF49667.1 - 0.0025 18.0 26.9 0.0042 17.2 26.9 1.4 1 0 0 1 1 1 1 Coiled-coil domain containing protein (DUF2052) SDA1 PF05285.12 CCF49667.1 - 0.0092 15.4 29.5 0.012 15.1 29.5 1.2 1 0 0 1 1 1 1 SDA1 Nop14 PF04147.12 CCF49667.1 - 0.012 13.9 31.8 0.013 13.7 31.8 1.1 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.14 CCF49667.1 - 0.031 12.6 24.7 0.035 12.4 24.7 1.2 1 0 0 1 1 1 0 CDC45-like protein PI3K_1B_p101 PF10486.9 CCF49667.1 - 0.051 11.4 13.3 0.05 11.4 13.3 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit CENP-W PF15510.6 CCF49667.1 - 0.072 13.3 0.1 0.072 13.3 0.1 1.6 2 0 0 2 2 1 0 CENP-W protein RR_TM4-6 PF06459.12 CCF49667.1 - 0.14 11.9 22.2 0.18 11.6 22.2 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 RRN3 PF05327.11 CCF49667.1 - 0.21 10.1 15.4 0.22 10.0 15.4 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 BUD22 PF09073.10 CCF49667.1 - 0.25 10.6 27.6 0.3 10.4 27.6 1.2 1 0 0 1 1 1 0 BUD22 GAGA_bind PF06217.12 CCF49667.1 - 0.73 10.1 11.6 0.93 9.7 11.6 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family Lin-8 PF03353.15 CCF49667.1 - 1.8 8.1 20.8 2.3 7.7 20.8 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist TP53IP5 PF15331.6 CCF49667.1 - 1.9 8.6 17.0 2.8 8.0 17.0 1.2 1 0 0 1 1 1 0 Cellular tumour antigen p53-inducible 5 CCSAP PF15748.5 CCF49667.1 - 2.5 8.2 23.2 3.7 7.6 23.2 1.2 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated DUF740 PF05340.12 CCF49667.1 - 2.5 6.7 15.4 3.2 6.4 15.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF740) DUF2151 PF10221.9 CCF49667.1 - 4.8 5.6 15.6 5.5 5.5 15.6 1.1 1 0 0 1 1 1 0 Cell cycle and development regulator Raftlin PF15250.6 CCF49667.1 - 6.8 5.3 14.3 8.2 5.0 14.3 1.2 1 0 0 1 1 1 0 Raftlin DNA_pol_phi PF04931.13 CCF49667.1 - 9.6 4.2 43.2 13 3.7 43.2 1.2 1 0 0 1 1 1 0 DNA polymerase phi Mlh1_C PF16413.5 CCF49668.1 - 1.7e-72 244.1 0.0 2.8e-72 243.3 0.0 1.4 1 0 0 1 1 1 1 DNA mismatch repair protein Mlh1 C-terminus DNA_mis_repair PF01119.19 CCF49668.1 - 3.5e-31 107.3 0.0 6.4e-31 106.5 0.0 1.4 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.6 CCF49668.1 - 2.6e-11 43.5 0.0 8.7e-11 41.8 0.0 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 CCF49668.1 - 1.8e-07 31.6 0.0 1.4e-06 28.7 0.0 2.3 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Carb_anhydrase PF00194.21 CCF49668.1 - 0.018 14.6 0.2 0.038 13.5 0.2 1.4 1 0 0 1 1 1 0 Eukaryotic-type carbonic anhydrase Clathrin_lg_ch PF01086.17 CCF49668.1 - 4.6 7.2 6.8 7.9 6.5 0.3 2.2 2 0 0 2 2 2 0 Clathrin light chain ALG11_N PF15924.5 CCF49669.1 - 3.2e-84 282.2 0.0 6e-84 281.3 0.0 1.5 1 0 0 1 1 1 1 ALG11 mannosyltransferase N-terminus EBP PF05241.12 CCF49669.1 - 4.2e-46 156.7 6.4 7.9e-46 155.7 6.4 1.5 1 0 0 1 1 1 1 Emopamil binding protein Glycos_transf_1 PF00534.20 CCF49669.1 - 5.5e-13 48.8 0.0 1.2e-12 47.7 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 CCF49669.1 - 2.7e-06 27.5 0.0 5.3e-06 26.5 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_1_4 PF13692.6 CCF49669.1 - 0.00013 22.4 0.0 0.00034 21.0 0.0 1.7 1 0 0 1 1 1 1 Glycosyl transferases group 1 DASH_Dam1 PF08653.10 CCF49671.1 - 2.8e-20 71.9 0.1 4.8e-20 71.1 0.1 1.4 1 0 0 1 1 1 1 DASH complex subunit Dam1 TFIIA PF03153.13 CCF49671.1 - 7.5e-05 22.9 11.8 7.5e-05 22.9 11.8 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Spt20 PF12090.8 CCF49671.1 - 0.029 14.0 19.1 0.043 13.4 19.1 1.3 1 0 0 1 1 1 0 Spt20 family TMEM51 PF15345.6 CCF49671.1 - 0.041 13.7 7.8 0.07 13.0 7.8 1.4 1 0 0 1 1 1 0 Transmembrane protein 51 HTH_9 PF08221.11 CCF49671.1 - 0.15 12.2 0.1 0.38 10.9 0.1 1.6 1 0 0 1 1 1 0 RNA polymerase III subunit RPC82 helix-turn-helix domain TERB2 PF15101.6 CCF49671.1 - 0.33 11.0 7.8 0.57 10.2 7.8 1.4 1 0 0 1 1 1 0 Telomere-associated protein TERB2 PAT1 PF09770.9 CCF49671.1 - 1.6 6.9 17.6 2.1 6.5 17.6 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Presenilin PF01080.17 CCF49671.1 - 2.4 6.8 6.2 3.5 6.3 6.2 1.3 1 0 0 1 1 1 0 Presenilin DUF4834 PF16118.5 CCF49671.1 - 2.5 9.1 6.9 5.8 7.9 6.9 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) B12D PF06522.11 CCF49672.1 - 2.9e-06 27.0 0.0 5.9e-06 26.0 0.0 1.6 1 1 0 1 1 1 1 NADH-ubiquinone reductase complex 1 MLRQ subunit Methyltransf_16 PF10294.9 CCF49673.1 - 6.1e-36 123.8 0.0 2.3e-35 121.9 0.0 1.7 1 1 0 1 1 1 1 Lysine methyltransferase Ras PF00071.22 CCF49674.1 - 3.4e-52 176.3 0.0 4.3e-52 176.0 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CCF49674.1 - 1.2e-29 103.0 0.0 2.7e-29 101.8 0.0 1.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CCF49674.1 - 2.3e-12 46.7 0.0 3.5e-12 46.1 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 CCF49674.1 - 2.3e-05 24.5 0.0 4.3e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 CCF49674.1 - 0.016 14.7 0.0 0.054 13.0 0.0 1.8 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 CCF49674.1 - 0.15 12.0 0.0 0.45 10.4 0.0 1.7 1 0 0 1 1 1 0 RsgA GTPase Myb_DNA-binding PF00249.31 CCF49675.1 - 2.1e-11 43.8 0.0 5e-11 42.6 0.0 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain SWIRM PF04433.17 CCF49675.1 - 3.4e-10 40.1 0.0 1.3e-09 38.3 0.0 1.9 2 0 0 2 2 2 1 SWIRM domain ZZ PF00569.17 CCF49675.1 - 6.1e-08 32.4 5.4 1.1e-07 31.5 5.4 1.4 1 0 0 1 1 1 1 Zinc finger, ZZ type Myb_DNA-bind_6 PF13921.6 CCF49675.1 - 1.4e-07 31.6 0.0 4.2e-07 30.1 0.0 1.8 1 0 0 1 1 1 1 Myb-like DNA-binding domain RNA_pol_Rpc4 PF05132.14 CCF49675.1 - 0.76 10.2 10.5 7.3 7.0 1.0 2.7 2 0 0 2 2 2 0 RNA polymerase III RPC4 Vfa1 PF08432.10 CCF49675.1 - 2.6 8.3 13.7 2.5 8.4 6.2 2.5 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 DEAD PF00270.29 CCF49676.1 - 3.7e-47 160.3 0.0 6.9e-47 159.5 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CCF49676.1 - 4.7e-31 107.4 0.1 2e-30 105.4 0.0 2.1 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 CCF49676.1 - 2.4e-05 24.4 0.0 4.3e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DUF4692 PF15763.5 CCF49676.1 - 4.5 7.7 8.4 10 6.6 8.4 1.5 1 0 0 1 1 1 0 Regulator of human erythroid cell expansion (RHEX) TFIIE-A_C PF11521.8 CCF49676.1 - 6.5 7.1 6.8 0.34 11.2 0.2 2.2 3 0 0 3 3 3 0 C-terminal general transcription factor TFIIE alpha zf-HIT PF04438.16 CCF49677.1 - 4.9e-08 32.7 10.5 7.5e-08 32.1 10.5 1.3 1 0 0 1 1 1 1 HIT zinc finger PTPRCAP PF15713.5 CCF49677.1 - 0.00055 20.2 2.4 0.00055 20.2 2.4 2.2 2 1 0 2 2 2 1 Protein tyrosine phosphatase receptor type C-associated ECD PF18432.1 CCF49677.1 - 0.13 12.2 0.0 2.4 8.2 0.0 2.3 1 1 1 2 2 2 0 Extracellular Cadherin domain Pkinase PF00069.25 CCF49678.1 - 5.5e-37 127.6 0.0 3.3e-26 92.2 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CCF49678.1 - 2.4e-20 72.9 0.0 3.5e-20 72.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CCF49678.1 - 3.1e-08 32.8 0.0 4.6e-08 32.3 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase DUF3844 PF12955.7 CCF49679.1 - 5.9e-28 97.1 2.3 1e-27 96.3 2.3 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3844) AviRa PF11599.8 CCF49679.1 - 0.07 12.6 0.9 1 8.8 0.0 2.7 3 0 0 3 3 3 0 RRNA methyltransferase AviRa Anti-TRAP PF15777.5 CCF49679.1 - 0.19 11.7 1.7 0.4 10.7 1.7 1.4 1 0 0 1 1 1 0 Tryptophan RNA-binding attenuator protein inhibitory protein ERO1 PF04137.15 CCF49681.1 - 2.8e-129 431.4 0.0 3.3e-129 431.1 0.0 1.1 1 0 0 1 1 1 1 Endoplasmic Reticulum Oxidoreductin 1 (ERO1) CDP-OH_P_transf PF01066.21 CCF49682.1 - 1.7e-15 57.5 1.0 1.7e-15 57.5 1.0 2.6 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase PPTA PF01239.22 CCF49683.1 - 9e-41 136.5 19.5 2.1e-09 36.8 0.1 5.7 6 0 0 6 6 6 5 Protein prenyltransferase alpha subunit repeat RNA_pol_Rpb1_7 PF04990.12 CCF49683.1 - 0.057 13.4 0.0 0.11 12.4 0.0 1.5 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 7 TPR_19 PF14559.6 CCF49683.1 - 0.094 13.2 0.2 1.1 9.8 0.1 2.7 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF1899 PF08953.11 CCF49684.1 - 0.1 12.5 1.0 5.6 6.9 0.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1899) U71 PF17474.2 CCF49684.1 - 9.1 6.3 9.8 1.6 8.7 1.4 2.4 2 0 0 2 2 2 0 Tegument protein UL11 homolog Glyco_hydro_30 PF02055.16 CCF49685.1 - 6.2e-19 68.2 0.1 8.6e-19 67.7 0.1 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 30 TIM-barrel domain Glyco_hydro_59 PF02057.15 CCF49685.1 - 4.2e-13 49.2 0.1 7e-13 48.5 0.1 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 59 MecA PF05389.12 CCF49686.1 - 0.051 13.2 3.1 0.13 11.9 3.1 1.6 1 0 0 1 1 1 0 Negative regulator of genetic competence (MecA) EIIBC-GUT_N PF03612.14 CCF49686.1 - 1.1 9.0 5.0 2.6 7.7 5.0 1.6 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus DUF775 PF05603.12 CCF49686.1 - 1.9 8.0 13.8 20 4.7 10.8 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF775) Connexin PF00029.19 CCF49686.1 - 3 7.5 4.0 5.7 6.6 4.0 1.4 1 0 0 1 1 1 0 Connexin MPM1 PF17234.2 CCF49686.1 - 3.2 8.0 13.4 0.068 13.4 5.7 2.1 2 0 0 2 2 2 0 Mitochondrial peculiar membrane protein 1 DUF4637 PF15470.6 CCF49686.1 - 3.5 7.3 8.0 17 5.1 8.0 2.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) V_ATPase_I PF01496.19 CCF49686.1 - 5.3 4.8 6.2 8 4.2 6.2 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Muskelin_N PF06588.11 CCF49687.1 - 1.4e-50 172.0 0.3 6.7e-20 71.8 0.0 3.5 3 1 0 3 3 3 3 Muskelin N-terminus Kelch_3 PF13415.6 CCF49687.1 - 1.2e-16 60.5 11.2 5.3e-09 36.1 0.1 5.9 7 0 0 7 7 7 3 Galactose oxidase, central domain Kelch_5 PF13854.6 CCF49687.1 - 8.4e-16 57.6 1.1 0.0067 16.4 0.1 5.8 5 0 0 5 5 5 5 Kelch motif Kelch_6 PF13964.6 CCF49687.1 - 1.3e-12 47.5 4.2 0.0028 17.9 0.0 6.7 7 0 0 7 7 7 3 Kelch motif Kelch_1 PF01344.25 CCF49687.1 - 1.3e-10 40.7 6.8 7.2e-05 22.3 0.1 6.0 6 0 0 6 6 6 2 Kelch motif Kelch_4 PF13418.6 CCF49687.1 - 4.5e-09 36.2 14.6 0.0029 17.6 0.2 6.8 7 0 0 7 7 7 3 Galactose oxidase, central domain Kelch_2 PF07646.15 CCF49687.1 - 0.00016 21.5 5.3 0.011 15.7 0.2 4.8 5 0 0 5 5 5 1 Kelch motif Tho1_MOS11_C PF18592.1 CCF49688.1 - 1.9e-14 53.2 2.0 1.9e-14 53.2 2.0 2.4 2 0 0 2 2 2 1 Tho1/MOS11 C-terminal domain SAP PF02037.27 CCF49688.1 - 2.3e-11 43.2 2.7 9.2e-11 41.2 0.4 2.4 2 0 0 2 2 2 1 SAP domain DEC-1_N PF04625.13 CCF49688.1 - 0.2 10.6 12.5 0.28 10.1 12.5 1.3 1 1 0 1 1 1 0 DEC-1 protein, N-terminal region Paf1 PF03985.13 CCF49688.1 - 4.4 6.2 16.1 6.2 5.7 16.1 1.1 1 0 0 1 1 1 0 Paf1 DUF5134 PF17197.4 CCF49689.1 - 0.022 14.7 1.1 0.032 14.1 1.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5134) SH2 PF00017.24 CCF49690.1 - 0.069 13.2 0.0 0.13 12.4 0.0 1.4 1 0 0 1 1 1 0 SH2 domain ubiquitin PF00240.23 CCF49691.1 - 3.1e-22 78.1 0.2 7.7e-22 76.8 0.2 1.7 1 0 0 1 1 1 1 Ubiquitin family UBA PF00627.31 CCF49691.1 - 4.9e-22 77.4 6.2 3.6e-13 49.1 0.4 2.9 3 0 0 3 3 3 2 UBA/TS-N domain XPC-binding PF09280.11 CCF49691.1 - 8.5e-15 54.2 6.7 8.5e-15 54.2 6.7 2.3 2 0 0 2 2 1 1 XPC-binding domain Rad60-SLD PF11976.8 CCF49691.1 - 2.2e-07 30.6 0.5 2.2e-07 30.6 0.5 1.7 2 0 0 2 2 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2722 PF10846.8 CCF49691.1 - 2.8e-05 23.3 6.1 2.8e-05 23.3 6.1 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF2722) Spt20 PF12090.8 CCF49691.1 - 0.0039 16.8 17.4 0.0039 16.8 17.4 2.2 2 0 0 2 2 2 1 Spt20 family TFIIA PF03153.13 CCF49691.1 - 0.0057 16.7 25.0 0.0057 16.7 25.0 2.0 2 0 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit Rad60-SLD_2 PF13881.6 CCF49691.1 - 0.036 14.2 0.0 0.036 14.2 0.0 2.3 2 0 0 2 2 2 0 Ubiquitin-2 like Rad60 SUMO-like MCM_N PF14551.6 CCF49691.1 - 0.051 14.2 1.7 2.9 8.5 0.0 2.4 2 0 0 2 2 2 0 MCM N-terminal domain CNDH2_N PF06278.11 CCF49691.1 - 0.19 11.9 3.9 0.46 10.7 3.9 1.6 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, N-terminal TERB2 PF15101.6 CCF49691.1 - 0.7 9.9 6.6 1.7 8.7 6.6 1.6 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Presenilin PF01080.17 CCF49691.1 - 0.87 8.3 7.7 1.3 7.7 7.7 1.2 1 0 0 1 1 1 0 Presenilin ANAPC_CDC26 PF10471.9 CCF49691.1 - 0.87 10.5 22.3 0.081 13.8 14.2 2.7 2 0 0 2 2 2 0 Anaphase-promoting complex APC subunit CDC26 GREB1 PF15782.5 CCF49691.1 - 2.1 5.4 7.6 2.7 5.0 7.6 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DUF4456 PF14644.6 CCF49691.1 - 2.6 7.7 14.2 8.8 6.0 10.5 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4456) Ig_mannosidase PF17753.1 CCF49692.1 - 8.6e-14 51.1 0.0 2.7e-13 49.4 0.0 1.9 2 0 0 2 2 2 1 Ig-fold domain Glyco_hydro_2 PF00703.21 CCF49692.1 - 0.0033 18.1 0.1 0.26 12.0 0.0 2.7 2 0 0 2 2 2 1 Glycosyl hydrolases family 2 FAD_binding_3 PF01494.19 CCF49693.1 - 4.9e-18 65.5 0.0 1.9e-17 63.5 0.0 1.9 1 1 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 CCF49693.1 - 1.7e-05 24.2 0.0 0.0047 16.2 0.0 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 CCF49693.1 - 8.6e-05 21.6 0.0 0.045 12.6 0.0 2.1 2 0 0 2 2 2 2 Tryptophan halogenase NAD_binding_8 PF13450.6 CCF49693.1 - 8.9e-05 22.6 1.1 0.00023 21.4 1.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CCF49693.1 - 0.00062 19.4 0.0 0.0012 18.6 0.0 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 CCF49693.1 - 0.0016 18.9 0.2 0.0046 17.5 0.2 1.8 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 CCF49693.1 - 0.0029 17.0 0.1 0.12 11.7 0.0 2.5 3 0 0 3 3 3 1 Flavin containing amine oxidoreductase SE PF08491.10 CCF49693.1 - 0.0036 16.4 0.0 1.7 7.6 0.0 2.3 2 1 0 2 2 2 2 Squalene epoxidase FAD_binding_2 PF00890.24 CCF49693.1 - 0.0045 16.1 1.6 0.0073 15.4 1.6 1.3 1 0 0 1 1 1 1 FAD binding domain NAD_binding_9 PF13454.6 CCF49693.1 - 0.015 15.2 0.0 0.035 14.1 0.0 1.7 1 1 0 1 1 1 0 FAD-NAD(P)-binding SAS-6_N PF16531.5 CCF49693.1 - 0.029 14.9 0.0 0.074 13.6 0.0 1.6 1 0 0 1 1 1 0 Centriolar protein SAS N-terminal HI0933_like PF03486.14 CCF49693.1 - 0.088 11.5 0.7 0.14 10.9 0.7 1.2 1 0 0 1 1 1 0 HI0933-like protein POB3_N PF17292.2 CCF49693.1 - 0.13 12.6 0.0 0.3 11.5 0.0 1.5 1 0 0 1 1 1 0 POB3-like N-terminal PH domain PRA1 PF03208.19 CCF49694.1 - 8.7e-32 109.7 0.4 1.1e-31 109.4 0.4 1.0 1 0 0 1 1 1 1 PRA1 family protein Tetraspanin PF00335.20 CCF49694.1 - 0.48 10.1 4.6 0.64 9.7 4.6 1.2 1 0 0 1 1 1 0 Tetraspanin family SirB PF04247.12 CCF49694.1 - 0.75 9.9 4.8 1.3 9.1 3.6 1.8 1 1 1 2 2 2 0 Invasion gene expression up-regulator, SirB PP2C PF00481.21 CCF49695.1 - 9.7e-55 186.0 1.7 1.5e-54 185.3 0.0 2.2 2 0 0 2 2 2 1 Protein phosphatase 2C LRR_8 PF13855.6 CCF49695.1 - 8.5e-44 147.2 65.8 8.7e-08 31.8 1.9 9.8 6 2 4 10 10 10 9 Leucine rich repeat LRR_4 PF12799.7 CCF49695.1 - 2.9e-33 113.4 78.6 2.4e-06 27.7 0.8 13.6 5 4 5 12 12 12 12 Leucine Rich repeats (2 copies) Guanylate_cyc PF00211.20 CCF49695.1 - 7.3e-26 90.9 0.0 2.1e-25 89.4 0.0 1.8 2 0 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain LRR_9 PF14580.6 CCF49695.1 - 9.9e-07 28.4 24.2 0.0059 16.1 1.1 4.8 2 1 1 4 4 4 4 Leucine-rich repeat Stc1 PF12898.7 CCF49696.1 - 0.0018 18.8 4.8 0.0054 17.3 4.8 1.9 1 0 0 1 1 1 1 Stc1 domain FAM199X PF15814.5 CCF49696.1 - 0.0022 17.1 5.2 0.0041 16.2 5.2 1.4 1 0 0 1 1 1 1 Protein family FAM199X Sporozoite_P67 PF05642.11 CCF49696.1 - 0.065 11.3 1.0 0.094 10.8 1.0 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen tRNA-synt_2c PF01411.19 CCF49697.1 - 6.5e-212 704.9 0.0 9e-212 704.4 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (A) tRNA_SAD PF07973.14 CCF49697.1 - 1.2e-16 60.5 0.2 2.6e-16 59.4 0.2 1.6 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain DHHA1 PF02272.19 CCF49697.1 - 2.1e-11 44.4 10.6 2e-10 41.2 10.6 2.4 1 1 0 1 1 1 1 DHHA1 domain Tom37 PF10568.9 CCF49697.1 - 0.11 12.8 0.0 0.49 10.7 0.0 2.1 2 0 0 2 2 2 0 Outer mitochondrial membrane transport complex protein Ank_5 PF13857.6 CCF49698.1 - 9.9e-07 28.9 0.4 0.00025 21.3 0.1 2.7 2 1 0 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 CCF49698.1 - 2.4e-06 28.0 0.0 1.4e-05 25.6 0.0 2.0 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CCF49698.1 - 1.3e-05 25.6 0.1 0.022 15.3 0.1 2.5 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 CCF49698.1 - 6.1e-05 23.3 1.1 0.089 13.3 1.1 2.8 1 1 0 1 1 1 1 Ankyrin repeat Ank_3 PF13606.6 CCF49698.1 - 8.4e-05 22.7 0.4 1.2 10.0 0.0 3.4 3 0 0 3 3 3 2 Ankyrin repeat RMI1_N PF08585.12 CCF49699.1 - 4.1e-46 157.5 0.4 2.8e-45 154.7 0.0 2.0 2 0 0 2 2 2 1 RecQ mediated genome instability protein SF3b1 PF08920.10 CCF49700.1 - 3.9e-26 91.9 4.9 3.9e-26 91.9 4.9 3.0 2 1 1 3 3 2 1 Splicing factor 3B subunit 1 HEAT_2 PF13646.6 CCF49700.1 - 1.6e-12 47.6 8.5 0.0026 18.1 0.1 8.1 6 2 2 8 8 8 2 HEAT repeats HEAT_EZ PF13513.6 CCF49700.1 - 8.8e-12 45.3 4.3 0.021 15.3 0.0 7.1 7 1 1 8 8 7 3 HEAT-like repeat Adaptin_N PF01602.20 CCF49700.1 - 7.1e-08 31.4 2.5 0.096 11.2 0.2 4.2 1 1 2 4 4 4 2 Adaptin N terminal region Vac14_Fab1_bd PF12755.7 CCF49700.1 - 1.7e-06 28.5 0.6 2.3 8.9 0.0 5.2 5 0 0 5 5 5 2 Vacuolar 14 Fab1-binding region HEAT PF02985.22 CCF49700.1 - 2.2e-06 27.4 9.7 1.2 9.5 0.1 9.0 12 0 0 12 12 9 1 HEAT repeat UME PF08064.13 CCF49700.1 - 2.6e-05 24.1 0.4 0.17 11.8 0.0 4.6 4 3 2 6 6 6 1 UME (NUC010) domain CLASP_N PF12348.8 CCF49700.1 - 3.2e-05 23.6 2.0 0.075 12.6 0.0 4.1 4 1 0 4 4 4 1 CLASP N terminal NUC173 PF08161.12 CCF49700.1 - 6.4e-05 22.7 3.8 1 9.0 0.0 4.9 4 2 1 5 5 5 2 NUC173 domain DUF3385 PF11865.8 CCF49700.1 - 7.1e-05 22.8 4.2 0.16 11.9 0.4 5.0 5 1 0 5 5 5 2 Domain of unknown function (DUF3385) Cnd1 PF12717.7 CCF49700.1 - 0.00012 22.2 8.4 5.9 6.9 0.0 6.6 7 1 0 7 7 7 2 non-SMC mitotic condensation complex subunit 1 MMS19_C PF12460.8 CCF49700.1 - 0.00022 20.5 0.1 1.4 8.0 0.0 3.8 4 0 0 4 4 4 2 RNAPII transcription regulator C-terminal Dopey_N PF04118.14 CCF49700.1 - 0.00098 18.3 1.7 0.077 12.1 0.0 3.3 2 1 0 3 3 3 1 Dopey, N-terminal LIDHydrolase PF10230.9 CCF49700.1 - 0.0045 16.6 0.4 0.055 13.0 0.1 2.5 2 0 0 2 2 2 1 Lipid-droplet associated hydrolase N1221 PF07923.13 CCF49700.1 - 0.088 12.0 2.0 4.9 6.2 0.0 3.2 3 0 0 3 3 3 0 N1221-like protein Mitoc_L55 PF09776.9 CCF49700.1 - 9.6 6.0 6.6 1.3 8.8 0.1 2.5 2 0 0 2 2 2 0 Mitochondrial ribosomal protein L55 MOZ_SAS PF01853.18 CCF49701.1 - 4e-81 271.0 0.3 6e-81 270.4 0.3 1.3 1 0 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 CCF49701.1 - 4.5e-24 83.8 1.8 9.6e-24 82.8 1.8 1.6 1 0 0 1 1 1 1 MYST family zinc finger domain Tudor-knot PF11717.8 CCF49701.1 - 2e-23 82.0 0.0 4.4e-23 80.9 0.0 1.6 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Acetyltransf_7 PF13508.7 CCF49701.1 - 0.0058 17.0 0.0 0.014 15.8 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CCF49701.1 - 0.053 13.8 0.2 0.23 11.7 0.0 2.1 3 0 0 3 3 3 0 Acetyltransferase (GNAT) family Hva1_TUDOR PF11160.8 CCF49702.1 - 1.7e-14 53.7 2.3 2e-14 53.5 2.3 1.1 1 0 0 1 1 1 1 Hypervirulence associated proteins TUDOR domain SIR2 PF02146.17 CCF49707.1 - 3.3e-31 108.6 0.0 1e-29 103.7 0.0 2.1 1 1 0 1 1 1 1 Sir2 family Na_Ca_ex PF01699.24 CCF49708.1 - 1.2e-27 96.7 23.7 3.2e-14 53.1 6.1 2.7 2 1 0 2 2 2 2 Sodium/calcium exchanger protein DUF1686 PF07937.11 CCF49708.1 - 0.035 14.0 0.6 0.072 13.0 0.6 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1686) Saf_2TM PF18303.1 CCF49708.1 - 0.073 12.7 3.9 0.12 12.0 1.6 2.5 1 1 0 2 2 2 0 SAVED-fused 2TM effector domain PAC4 PF16093.5 CCF49708.1 - 0.13 12.4 1.9 0.4 10.9 1.9 1.8 1 1 0 1 1 1 0 Proteasome assembly chaperone 4 Spore_permease PF03845.13 CCF49708.1 - 0.18 10.6 7.2 0.038 12.8 1.3 2.2 2 0 0 2 2 2 0 Spore germination protein FUSC_2 PF13515.6 CCF49708.1 - 1.8 8.7 13.7 0.035 14.2 2.0 3.1 3 0 0 3 3 3 0 Fusaric acid resistance protein-like Ribosomal_S8e PF01201.22 CCF49710.1 - 4.9e-46 156.3 2.1 1e-45 155.3 2.1 1.4 1 1 0 1 1 1 1 Ribosomal protein S8e Red1 PF07964.11 CCF49710.1 - 0.68 8.1 5.8 0.76 7.9 5.8 1.1 1 0 0 1 1 1 0 Rec10 / Red1 Macoilin PF09726.9 CCF49710.1 - 7.5 5.0 10.5 9.9 4.6 10.5 1.0 1 0 0 1 1 1 0 Macoilin family ABC2_membrane PF01061.24 CCF49711.1 - 5.3e-66 222.0 47.3 6.5e-37 127.0 18.7 2.4 2 0 0 2 2 2 2 ABC-2 type transporter ABC_tran PF00005.27 CCF49711.1 - 3.1e-36 124.9 0.0 2.8e-17 63.5 0.0 2.6 2 0 0 2 2 2 2 ABC transporter PDR_CDR PF06422.12 CCF49711.1 - 6.1e-19 67.7 6.1 4.2e-17 61.8 0.0 3.5 3 0 0 3 3 3 2 CDR ABC transporter AAA_16 PF13191.6 CCF49711.1 - 5e-08 33.5 1.4 0.00014 22.3 0.3 2.7 2 0 0 2 2 2 2 AAA ATPase domain ABC_trans_N PF14510.6 CCF49711.1 - 2.6e-05 24.7 0.0 7.4e-05 23.3 0.0 1.8 1 0 0 1 1 1 1 ABC-transporter N-terminal AAA_21 PF13304.6 CCF49711.1 - 5.7e-05 23.1 1.2 0.25 11.1 0.0 2.4 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 CCF49711.1 - 0.00036 20.2 2.5 0.054 13.2 0.5 2.6 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_18 PF13238.6 CCF49711.1 - 0.00069 20.2 0.0 0.063 13.8 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 CCF49711.1 - 0.0013 19.0 0.7 0.81 10.0 0.4 2.7 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.6 CCF49711.1 - 0.0014 18.3 0.3 0.011 15.3 0.2 2.3 2 0 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 CCF49711.1 - 0.0035 17.3 1.4 0.0083 16.0 0.1 2.0 2 0 0 2 2 2 1 RsgA GTPase AAA_30 PF13604.6 CCF49711.1 - 0.021 14.5 1.6 1.3 8.7 0.1 2.9 3 0 0 3 3 3 0 AAA domain SMC_N PF02463.19 CCF49711.1 - 0.032 13.7 0.0 1.9 7.9 0.0 2.6 3 0 0 3 3 3 0 RecF/RecN/SMC N terminal domain Methyltransf_34 PF11312.8 CCF49711.1 - 0.039 13.2 0.0 0.072 12.3 0.0 1.3 1 0 0 1 1 1 0 Putative SAM-dependent methyltransferase MMR_HSR1 PF01926.23 CCF49711.1 - 0.043 13.9 1.2 3.8 7.6 0.2 2.6 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_23 PF13476.6 CCF49711.1 - 0.099 13.1 3.7 0.53 10.8 0.4 2.8 2 1 0 2 2 2 0 AAA domain AAA_33 PF13671.6 CCF49711.1 - 0.15 12.2 0.1 1.3 9.2 0.0 2.4 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 CCF49711.1 - 0.25 11.3 1.2 5.3 6.9 0.5 2.5 2 0 0 2 2 2 0 NACHT domain ABC_ATPase PF09818.9 CCF49711.1 - 0.66 8.7 2.2 0.68 8.7 0.9 1.6 2 0 0 2 2 2 0 Predicted ATPase of the ABC class FtsK_SpoIIIE PF01580.18 CCF49711.1 - 1.1 8.5 3.8 11 5.3 0.1 3.1 4 0 0 4 4 4 0 FtsK/SpoIIIE family AAA_28 PF13521.6 CCF49711.1 - 2.9 8.1 10.2 0.038 14.2 1.3 2.5 3 0 0 3 3 2 0 AAA domain adh_short_C2 PF13561.6 CCF49713.1 - 3.2e-55 187.2 1.1 3.7e-55 187.0 1.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCF49713.1 - 2.8e-41 141.1 1.4 3.7e-41 140.7 1.4 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CCF49713.1 - 1.7e-10 41.1 0.4 2.5e-10 40.6 0.4 1.2 1 0 0 1 1 1 1 KR domain SBP_bac_11 PF13531.6 CCF49713.1 - 0.029 14.1 0.4 0.075 12.8 0.4 1.8 1 1 0 1 1 1 0 Bacterial extracellular solute-binding protein S4 PF01479.25 CCF49713.1 - 0.056 13.2 0.0 0.14 11.9 0.0 1.7 1 0 0 1 1 1 0 S4 domain Epimerase PF01370.21 CCF49713.1 - 0.14 11.6 0.9 1.2 8.5 0.9 2.3 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family ox_reductase_C PF08635.10 CCF49714.1 - 7e-52 174.9 0.0 1.3e-51 174.0 0.0 1.4 1 0 0 1 1 1 1 Putative oxidoreductase C terminal domain GFO_IDH_MocA PF01408.22 CCF49714.1 - 1e-12 48.9 0.0 1.6e-12 48.3 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 CCF49714.1 - 6.5e-07 29.4 0.0 1.4e-06 28.3 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain XPG_I PF00867.18 CCF49714.1 - 0.028 14.8 0.0 0.31 11.4 0.0 2.3 2 0 0 2 2 2 0 XPG I-region NAD_binding_10 PF13460.6 CCF49715.1 - 7.5e-10 39.0 0.3 1.4e-09 38.1 0.0 1.6 2 0 0 2 2 2 1 NAD(P)H-binding Dabb PF07876.12 CCF49716.1 - 4.7e-17 62.4 0.5 5.2e-17 62.2 0.5 1.0 1 0 0 1 1 1 1 Stress responsive A/B Barrel Domain CHASE8 PF17152.4 CCF49716.1 - 0.13 12.5 0.0 0.2 11.9 0.0 1.4 1 1 0 1 1 1 0 Periplasmic sensor domain ADIP PF11559.8 CCF49717.1 - 4.5e-28 98.2 8.1 4.5e-28 98.2 8.1 6.0 5 1 2 7 7 7 2 Afadin- and alpha -actinin-Binding ERM PF00769.19 CCF49717.1 - 0.0066 16.3 17.5 0.0066 16.3 17.5 4.7 3 1 1 4 4 4 1 Ezrin/radixin/moesin family Histone PF00125.24 CCF49718.1 - 5.9e-41 139.9 0.1 7.5e-41 139.6 0.1 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 CCF49718.1 - 0.027 14.6 0.0 0.056 13.6 0.0 1.5 1 1 0 1 1 1 0 Centromere kinetochore component CENP-T histone fold Nup35_RRM PF05172.13 CCF49719.1 - 1.7e-07 31.1 0.0 4.4e-07 29.8 0.0 1.6 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif Nup35_RRM_2 PF14605.6 CCF49719.1 - 0.017 15.1 0.0 0.036 14.1 0.0 1.5 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif DUF4638 PF15472.6 CCF49719.1 - 0.53 10.0 3.1 1.1 9.0 3.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) DAO PF01266.24 CCF49720.1 - 1.9e-59 202.0 0.2 2.2e-59 201.8 0.2 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CCF49720.1 - 6.7e-07 28.8 0.4 0.00099 18.4 0.2 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CCF49720.1 - 1.5e-06 28.7 0.4 0.0012 19.4 0.1 2.6 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CCF49720.1 - 0.0005 20.2 0.5 0.0012 19.0 0.5 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Mqo PF06039.15 CCF49720.1 - 0.0018 16.9 0.1 0.65 8.5 0.0 2.1 2 0 0 2 2 2 2 Malate:quinone oxidoreductase (Mqo) Trp_halogenase PF04820.14 CCF49720.1 - 0.0041 16.0 0.5 0.0062 15.4 0.5 1.2 1 0 0 1 1 1 1 Tryptophan halogenase Sacchrp_dh_NADP PF03435.18 CCF49720.1 - 0.013 15.7 0.1 0.036 14.3 0.1 1.7 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain MCRA PF06100.11 CCF49720.1 - 0.015 14.1 0.1 0.67 8.7 0.0 2.1 2 0 0 2 2 2 0 MCRA family K_oxygenase PF13434.6 CCF49720.1 - 0.018 14.2 0.2 0.22 10.6 0.1 2.0 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) GMC_oxred_N PF00732.19 CCF49720.1 - 0.039 13.3 0.1 1.7 8.0 0.0 2.1 2 0 0 2 2 2 0 GMC oxidoreductase NAD_binding_9 PF13454.6 CCF49720.1 - 0.04 13.9 0.3 0.25 11.3 0.1 2.1 2 0 0 2 2 2 0 FAD-NAD(P)-binding TrkA_N PF02254.18 CCF49720.1 - 0.071 13.4 0.0 0.14 12.5 0.0 1.5 1 0 0 1 1 1 0 TrkA-N domain ApbA PF02558.16 CCF49720.1 - 0.075 12.7 0.7 0.22 11.2 0.3 1.8 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA Thi4 PF01946.17 CCF49720.1 - 0.076 12.2 0.1 0.13 11.5 0.1 1.3 1 0 0 1 1 1 0 Thi4 family FAD_binding_2 PF00890.24 CCF49720.1 - 0.15 11.1 5.5 0.95 8.5 5.5 2.0 1 1 0 1 1 1 0 FAD binding domain Sugar_tr PF00083.24 CCF49721.1 - 8.4e-22 77.6 22.1 8.6e-20 71.0 22.1 2.1 1 1 0 1 1 1 1 Sugar (and other) transporter SAM_1 PF00536.30 CCF49723.1 - 8e-14 51.8 0.1 1.6e-13 50.9 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) RA PF00788.23 CCF49723.1 - 1.7e-13 51.0 0.0 3.1e-13 50.2 0.0 1.4 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain SAM_2 PF07647.17 CCF49723.1 - 2.1e-13 50.2 0.0 3.4e-13 49.5 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SH3_1 PF00018.28 CCF49723.1 - 8.6e-13 47.7 0.4 1.3e-07 31.1 0.1 2.8 2 0 0 2 2 2 2 SH3 domain SH3_9 PF14604.6 CCF49723.1 - 4.8e-10 39.1 1.4 6.8e-06 25.8 0.1 3.0 2 0 0 2 2 2 2 Variant SH3 domain SH3_3 PF08239.11 CCF49723.1 - 0.0066 16.7 0.3 0.0066 16.7 0.3 3.7 3 1 0 3 3 3 1 Bacterial SH3 domain Retrotran_gag_2 PF14223.6 CCF49724.1 - 0.00072 19.2 1.6 0.00082 19.0 0.4 1.7 2 0 0 2 2 2 1 gag-polypeptide of LTR copia-type ArnB_C PF18677.1 CCF49724.1 - 0.019 15.0 0.3 0.083 13.0 0.0 2.1 2 0 0 2 2 2 0 Archaellum regulatory network B, C-terminal domain DUF4219 PF13961.6 CCF49724.1 - 0.17 11.6 0.7 0.55 10.0 0.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4219) rve PF00665.26 CCF49725.1 - 6.8e-08 32.7 0.5 2.5e-07 30.9 0.5 1.8 1 1 1 2 2 2 2 Integrase core domain rve_3 PF13683.6 CCF49725.1 - 0.022 14.5 0.0 0.04 13.7 0.0 1.5 1 0 0 1 1 1 0 Integrase core domain TF_Zn_Ribbon PF08271.12 CCF49727.1 - 2.3e-05 23.8 0.4 4.4e-05 22.9 0.4 1.4 1 0 0 1 1 1 1 TFIIB zinc-binding Prim_Zn_Ribbon PF08273.12 CCF49727.1 - 0.0018 18.5 0.9 0.0034 17.6 0.9 1.4 1 0 0 1 1 1 1 Zinc-binding domain of primase-helicase zf-ribbon_3 PF13248.6 CCF49727.1 - 0.016 14.6 1.6 0.89 9.1 0.1 2.4 2 0 0 2 2 2 0 zinc-ribbon domain Zn_Tnp_IS1595 PF12760.7 CCF49727.1 - 0.021 14.8 0.2 0.044 13.8 0.2 1.6 1 0 0 1 1 1 0 Transposase zinc-ribbon domain MAGI_u5 PF16666.5 CCF49727.1 - 0.62 10.2 7.1 1.8 8.8 7.1 1.7 1 0 0 1 1 1 0 Unstructured region on MAGI ADH_N PF08240.12 CCF49728.1 - 2e-13 50.2 0.3 3.3e-13 49.5 0.3 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_N_assoc PF13823.6 CCF49728.1 - 1.9e-07 30.8 0.0 1.9e-07 30.8 0.0 2.1 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-associated ADH_zinc_N PF00107.26 CCF49728.1 - 0.0001 22.3 0.1 0.0097 15.9 0.0 2.4 1 1 1 2 2 2 2 Zinc-binding dehydrogenase SurE PF01975.17 CCF49730.1 - 1.9e-41 142.0 0.0 2.6e-41 141.5 0.0 1.2 1 0 0 1 1 1 1 Survival protein SurE Cation_ATPase_C PF00689.21 CCF49731.1 - 0.00013 21.8 3.2 0.00018 21.2 3.2 1.2 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 CCF49732.1 - 4.4e-31 107.8 0.1 8.4e-31 106.9 0.1 1.4 1 0 0 1 1 1 1 E1-E2 ATPase P5-ATPase PF12409.8 CCF49732.1 - 2e-25 89.3 0.0 8.3e-25 87.3 0.0 2.0 1 1 0 1 1 1 1 P5-type ATPase cation transporter Hydrolase PF00702.26 CCF49732.1 - 4.5e-18 66.3 0.1 1.8e-10 41.4 0.1 3.0 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 CCF49732.1 - 4.3e-06 26.3 0.0 8.4e-06 25.4 0.0 1.4 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Cation_ATPase PF13246.6 CCF49732.1 - 9.1e-06 25.7 0.0 2.8e-05 24.1 0.0 1.8 1 0 0 1 1 1 1 Cation transport ATPase (P-type) DUF1349 PF07081.11 CCF49733.1 - 1.8e-27 96.2 0.0 2.5e-27 95.8 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1349) AA_permease PF00324.21 CCF49735.1 - 1.4e-99 333.9 46.6 1.7e-99 333.6 46.6 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 CCF49735.1 - 4.2e-26 91.7 51.2 5e-26 91.5 51.2 1.0 1 0 0 1 1 1 1 Amino acid permease SLAC1 PF03595.17 CCF49736.1 - 6.9e-74 249.0 56.3 7.9e-74 248.8 56.3 1.0 1 0 0 1 1 1 1 Voltage-dependent anion channel MFS_1 PF07690.16 CCF49737.1 - 1.4e-27 96.5 54.9 3.9e-24 85.2 29.1 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Tim17 PF02466.19 CCF49737.1 - 0.061 13.7 0.6 0.26 11.7 0.6 2.1 1 1 0 1 1 1 0 Tim17/Tim22/Tim23/Pmp24 family DPPIV_N PF00930.21 CCF49738.1 - 3.1e-76 256.4 0.0 6.1e-76 255.5 0.0 1.5 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.21 CCF49738.1 - 1.8e-46 158.3 1.4 2.9e-46 157.6 1.4 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Peptidase_S15 PF02129.18 CCF49738.1 - 0.00049 19.8 2.2 0.0056 16.3 0.8 2.4 1 1 1 2 2 2 1 X-Pro dipeptidyl-peptidase (S15 family) Hydrolase_4 PF12146.8 CCF49738.1 - 0.00054 19.3 0.1 0.028 13.7 0.0 2.4 1 1 0 2 2 2 1 Serine aminopeptidase, S33 BAAT_C PF08840.11 CCF49738.1 - 0.00074 19.5 0.0 1.4 8.8 0.0 2.3 2 0 0 2 2 2 2 BAAT / Acyl-CoA thioester hydrolase C terminal Abhydrolase_6 PF12697.7 CCF49738.1 - 0.00075 20.2 0.2 0.0046 17.6 0.0 2.4 2 0 0 2 2 2 1 Alpha/beta hydrolase family AXE1 PF05448.12 CCF49738.1 - 0.031 13.0 0.0 2 7.0 0.0 2.3 2 0 0 2 2 2 0 Acetyl xylan esterase (AXE1) DUF3830 PF12903.7 CCF49738.1 - 0.05 13.3 0.0 0.1 12.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3830) zf-CCHC_4 PF14392.6 CCF49739.1 - 0.01 15.5 0.6 0.023 14.4 0.6 1.6 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC PF00098.23 CCF49739.1 - 0.011 15.8 1.2 0.019 15.0 1.2 1.4 1 0 0 1 1 1 0 Zinc knuckle Retrotran_gag_3 PF14244.6 CCF49739.1 - 0.052 13.4 0.0 0.23 11.3 0.0 1.9 2 0 0 2 2 2 0 gag-polypeptide of LTR copia-type DUF4219 PF13961.6 CCF49739.1 - 0.062 13.0 0.5 0.24 11.1 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4219) rve PF00665.26 CCF49740.1 - 9e-16 58.1 0.0 1.4e-15 57.5 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain gag_pre-integrs PF13976.6 CCF49740.1 - 1.6e-07 31.0 0.2 2.7e-07 30.3 0.2 1.5 1 0 0 1 1 1 1 GAG-pre-integrase domain rve_3 PF13683.6 CCF49740.1 - 0.11 12.3 0.0 0.21 11.4 0.0 1.5 1 0 0 1 1 1 0 Integrase core domain PBECR1 PF18809.1 CCF49740.1 - 0.29 11.8 2.9 0.86 10.3 0.4 2.1 2 0 0 2 2 2 0 phage-Barnase-EndoU-ColicinE5/D-RelE like nuclease1 RVT_2 PF07727.14 CCF49741.1 - 4.5e-38 131.3 0.1 3e-34 118.7 0.0 2.1 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) HSF_DNA-bind PF00447.17 CCF49742.1 - 4.6e-31 107.3 0.2 7.9e-31 106.5 0.2 1.4 1 0 0 1 1 1 1 HSF-type DNA-binding HAP1_N PF04849.13 CCF49742.1 - 0.038 13.2 0.1 0.057 12.6 0.1 1.1 1 0 0 1 1 1 0 HAP1 N-terminal conserved region TPR_MLP1_2 PF07926.12 CCF49742.1 - 0.17 11.9 1.0 0.31 11.1 1.0 1.3 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein BCDHK_Adom3 PF10436.9 CCF49743.1 - 1e-66 223.8 0.0 1.5e-66 223.3 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 CCF49743.1 - 1.8e-13 51.0 0.0 4.9e-13 49.6 0.0 1.7 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 CCF49743.1 - 0.00011 22.0 0.0 0.0003 20.6 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Mt_ATP-synt_B PF05405.14 CCF49746.1 - 7.2e-45 152.5 8.6 8.5e-45 152.3 8.6 1.0 1 0 0 1 1 1 1 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) LMBR1 PF04791.16 CCF49746.1 - 0.16 10.8 1.0 0.17 10.7 1.0 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF5623 PF18536.1 CCF49746.1 - 0.27 11.5 1.5 0.48 10.7 0.6 1.8 1 1 0 2 2 2 0 Domain of unknown function (DUF5623) Cauli_DNA-bind PF03310.13 CCF49746.1 - 0.57 10.3 4.3 0.26 11.3 1.7 1.7 2 0 0 2 2 2 0 Caulimovirus DNA-binding protein Fib_alpha PF08702.10 CCF49746.1 - 6.3 7.0 7.3 6.8 6.9 5.1 1.9 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Ank_4 PF13637.6 CCF49747.1 - 1.6e-17 63.6 1.2 2.2e-12 47.2 0.2 2.8 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 CCF49747.1 - 1.7e-15 57.4 0.1 1.7e-13 50.9 0.4 2.4 2 1 0 2 2 2 1 Ankyrin repeats (3 copies) Ank PF00023.30 CCF49747.1 - 2.6e-11 43.4 1.0 0.00025 21.3 0.4 3.3 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.6 CCF49747.1 - 2.7e-10 40.3 0.7 0.00074 19.8 0.1 2.9 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 CCF49747.1 - 9.3e-10 37.9 0.1 0.0042 17.5 0.0 3.7 4 0 0 4 4 4 2 Ankyrin repeat Nop53 PF07767.11 CCF49748.1 - 3.6e-106 355.9 26.8 4.6e-106 355.6 26.8 1.1 1 0 0 1 1 1 1 Nop53 (60S ribosomal biogenesis) YqfQ PF14181.6 CCF49748.1 - 0.013 15.7 4.7 0.051 13.8 4.7 2.0 1 0 0 1 1 1 0 YqfQ-like protein CDC45 PF02724.14 CCF49748.1 - 0.054 11.8 10.7 0.076 11.3 10.7 1.2 1 0 0 1 1 1 0 CDC45-like protein SWI-SNF_Ssr4 PF08549.10 CCF49749.1 - 1.4e-06 27.3 5.0 1.4e-06 27.3 5.0 4.2 2 2 0 2 2 2 1 Fungal domain of unknown function (DUF1750) Syntaxin_2 PF14523.6 CCF49749.1 - 0.092 13.1 1.2 0.18 12.2 1.2 1.3 1 0 0 1 1 1 0 Syntaxin-like protein Ssl1 PF04056.14 CCF49750.1 - 5.7e-69 231.8 0.0 8.4e-69 231.2 0.0 1.2 1 0 0 1 1 1 1 Ssl1-like C1_4 PF07975.12 CCF49750.1 - 2e-15 56.7 8.7 2e-15 56.7 8.7 2.4 2 0 0 2 2 2 1 TFIIH C1-like domain VWA_2 PF13519.6 CCF49750.1 - 6.8e-12 46.0 0.1 2.4e-11 44.2 0.0 1.9 2 0 0 2 2 2 1 von Willebrand factor type A domain zinc_ribbon_15 PF17032.5 CCF49750.1 - 0.00048 20.8 3.3 0.00048 20.8 3.3 2.4 1 1 1 2 2 2 1 zinc-ribbon family DNA_RNApol_7kD PF03604.13 CCF49750.1 - 7.5 6.3 10.6 13 5.5 2.3 2.6 2 0 0 2 2 2 0 DNA directed RNA polymerase, 7 kDa subunit IBR PF01485.21 CCF49750.1 - 8.8 6.6 15.5 1.5e+02 2.7 15.6 2.5 1 1 0 1 1 1 0 IBR domain, a half RING-finger domain Snf7 PF03357.21 CCF49751.1 - 3.2e-50 170.1 16.0 3.7e-50 169.9 16.0 1.0 1 0 0 1 1 1 1 Snf7 NuA4 PF09340.10 CCF49751.1 - 0.0025 17.6 0.9 0.0075 16.1 0.9 1.8 1 0 0 1 1 1 1 Histone acetyltransferase subunit NuA4 Soyouz_module PF14313.6 CCF49751.1 - 0.017 14.9 1.1 5.9 6.7 0.0 3.3 3 0 0 3 3 3 0 N-terminal region of Paramyxovirinae phosphoprotein (P) DUF1319 PF07028.11 CCF49751.1 - 0.037 14.3 1.9 0.059 13.6 0.8 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1319) DUF848 PF05852.11 CCF49751.1 - 0.041 14.0 7.6 0.027 14.6 5.3 1.8 1 1 1 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) FlaC_arch PF05377.11 CCF49751.1 - 0.094 13.1 7.1 1.7 9.1 0.1 3.6 2 1 2 4 4 3 0 Flagella accessory protein C (FlaC) Prefoldin PF02996.17 CCF49751.1 - 0.1 12.5 11.0 6.9 6.6 1.4 3.5 4 0 0 4 4 4 0 Prefoldin subunit PEP-utilisers_N PF05524.13 CCF49751.1 - 0.31 11.2 11.3 0.077 13.2 3.3 2.5 1 1 1 2 2 2 0 PEP-utilising enzyme, N-terminal Exonuc_VII_L PF02601.15 CCF49751.1 - 0.32 10.5 5.6 0.42 10.1 5.6 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit V_ATPase_I PF01496.19 CCF49751.1 - 0.33 8.8 7.7 0.4 8.5 7.7 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Prefoldin_2 PF01920.20 CCF49751.1 - 0.79 9.7 16.9 2 8.4 0.0 3.4 2 1 1 3 3 3 0 Prefoldin subunit FlxA PF14282.6 CCF49751.1 - 1.1 9.3 12.9 0.18 11.8 7.4 2.4 1 1 2 3 3 3 0 FlxA-like protein EMP24_GP25L PF01105.24 CCF49751.1 - 1.4 8.9 6.2 6.2 6.7 0.0 2.6 2 1 0 2 2 2 0 emp24/gp25L/p24 family/GOLD NPV_P10 PF05531.12 CCF49751.1 - 3.8 8.1 7.2 3.9 8.0 1.0 3.4 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein TBCA PF02970.16 CCF49751.1 - 4.9 7.6 12.2 1.7 9.1 7.9 2.3 2 0 0 2 2 2 0 Tubulin binding cofactor A DUF948 PF06103.11 CCF49751.1 - 4.9 7.5 6.5 36 4.7 4.1 2.8 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Uso1_p115_C PF04871.13 CCF49751.1 - 6.3 7.2 21.6 2.4e+02 2.1 18.8 3.0 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region BAR PF03114.18 CCF49752.1 - 1.4e-48 165.6 1.3 1.9e-48 165.2 1.3 1.1 1 0 0 1 1 1 1 BAR domain Arfaptin PF06456.13 CCF49752.1 - 0.0021 17.7 2.0 0.0042 16.7 2.0 1.8 1 1 0 1 1 1 1 Arfaptin-like domain Sulfotransfer_3 PF13469.6 CCF49752.1 - 0.006 17.0 0.5 0.011 16.1 0.5 1.4 1 1 0 1 1 1 1 Sulfotransferase family AAA_13 PF13166.6 CCF49752.1 - 0.012 14.4 1.9 0.015 13.9 1.9 1.2 1 0 0 1 1 1 0 AAA domain HD_3 PF13023.6 CCF49752.1 - 0.029 14.3 0.6 0.063 13.2 0.0 1.8 2 0 0 2 2 2 0 HD domain Sigma70_ner PF04546.13 CCF49752.1 - 0.043 13.7 0.3 0.043 13.7 0.3 2.8 1 1 2 3 3 3 0 Sigma-70, non-essential region Jnk-SapK_ap_N PF09744.9 CCF49752.1 - 0.044 14.0 2.5 0.45 10.7 1.2 2.5 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 Sec34 PF04136.15 CCF49752.1 - 0.046 13.6 0.3 0.15 11.9 0.1 2.0 2 0 0 2 2 2 0 Sec34-like family Laminin_I PF06008.14 CCF49752.1 - 0.12 12.1 2.2 0.31 10.7 2.2 1.9 1 1 0 1 1 1 0 Laminin Domain I CdvA PF18822.1 CCF49752.1 - 0.12 12.2 2.7 0.22 11.3 0.2 2.7 3 0 0 3 3 3 0 CdvA-like coiled-coil domain TMPIT PF07851.13 CCF49752.1 - 0.16 11.2 0.3 0.4 9.9 0.0 1.6 1 1 1 2 2 2 0 TMPIT-like protein Golgin_A5 PF09787.9 CCF49752.1 - 0.31 10.5 3.9 0.09 12.2 1.0 1.5 2 0 0 2 2 2 0 Golgin subfamily A member 5 IFT57 PF10498.9 CCF49752.1 - 0.51 9.3 3.7 0.37 9.7 1.6 1.7 1 1 1 2 2 2 0 Intra-flagellar transport protein 57 OmpH PF03938.14 CCF49752.1 - 3.2 8.1 8.9 0.64 10.4 2.3 2.6 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) Metallophos PF00149.28 CCF49754.1 - 8e-27 95.1 0.0 2.8e-26 93.3 0.0 1.8 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase PPP5 PF08321.12 CCF49754.1 - 7.6e-26 90.2 0.0 1.3e-25 89.5 0.0 1.4 1 0 0 1 1 1 1 PPP5 TPR repeat region TPR_1 PF00515.28 CCF49754.1 - 9e-11 41.1 4.8 0.00026 20.7 0.1 3.9 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 CCF49754.1 - 2.9e-07 30.1 4.8 0.095 12.9 0.2 3.7 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.6 CCF49754.1 - 4.4e-05 23.1 0.3 0.037 13.7 0.1 2.8 2 0 0 2 2 2 2 TPR repeat TPR_17 PF13431.6 CCF49754.1 - 0.00091 19.4 0.1 2.3 8.8 0.0 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 CCF49754.1 - 0.004 17.3 0.3 7.3 7.1 0.1 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 CCF49754.1 - 0.004 17.8 0.9 0.0076 16.9 0.1 1.8 2 0 0 2 2 2 1 Tetratricopeptide repeat DUF3809 PF12723.7 CCF49754.1 - 0.065 13.5 0.1 1.7 9.0 0.0 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3809) HAD_2 PF13419.6 CCF49755.1 - 3.1e-18 66.5 0.0 3.2e-14 53.4 0.0 2.1 2 0 0 2 2 2 2 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 CCF49755.1 - 3.2e-12 47.2 0.0 3.3e-11 43.9 0.0 2.3 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 CCF49755.1 - 0.0058 17.1 0.0 0.026 14.9 0.0 2.1 1 1 1 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 CCF49755.1 - 0.044 13.9 0.0 13 6.0 0.0 2.8 3 0 0 3 3 3 0 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 CCF49755.1 - 0.076 13.1 0.1 0.66 10.1 0.0 2.5 3 1 0 3 3 3 0 HAD-hyrolase-like Vps5 PF09325.10 CCF49756.1 - 9.1e-68 228.3 3.7 9.1e-68 228.3 3.7 2.2 2 0 0 2 2 2 1 Vps5 C terminal like RmlD_sub_bind PF04321.17 CCF49756.1 - 1.1e-49 169.1 0.0 2.3e-49 168.1 0.0 1.5 1 0 0 1 1 1 1 RmlD substrate binding domain Epimerase PF01370.21 CCF49756.1 - 1.1e-22 80.7 0.0 2e-22 79.9 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family PX PF00787.24 CCF49756.1 - 3.6e-22 78.5 0.0 9.1e-22 77.2 0.0 1.7 1 0 0 1 1 1 1 PX domain Polysacc_synt_2 PF02719.15 CCF49756.1 - 3e-08 33.2 0.1 1.1e-06 28.0 0.1 2.8 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein GDP_Man_Dehyd PF16363.5 CCF49756.1 - 3.8e-08 33.1 0.0 3.8e-08 33.1 0.0 2.3 2 1 0 2 2 2 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 CCF49756.1 - 0.002 17.3 0.1 0.018 14.2 0.0 2.5 1 1 1 2 2 2 1 Male sterility protein SAD_SRA PF02182.17 CCF49757.1 - 1.1e-51 174.7 0.0 2e-51 173.8 0.0 1.5 1 0 0 1 1 1 1 SAD/SRA domain Peptidase_S9_N PF02897.15 CCF49758.1 - 1.3e-85 287.7 3.5 1.6e-85 287.4 3.5 1.1 1 0 0 1 1 1 1 Prolyl oligopeptidase, N-terminal beta-propeller domain Peptidase_S9 PF00326.21 CCF49758.1 - 1.7e-48 164.9 0.1 2.9e-48 164.2 0.1 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family Pkinase PF00069.25 CCF49759.1 - 2.2e-71 240.3 0.0 2.5e-71 240.2 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF49759.1 - 8.5e-31 107.2 0.0 1.1e-30 106.9 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCF49759.1 - 0.00022 20.7 0.0 0.00032 20.1 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 CCF49759.1 - 0.00063 18.8 0.1 0.0062 15.5 0.1 1.9 2 0 0 2 2 2 1 Haspin like kinase domain APH PF01636.23 CCF49759.1 - 0.0018 18.2 0.0 0.0057 16.6 0.0 1.6 1 1 1 2 2 2 1 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 CCF49759.1 - 0.0065 15.6 0.0 0.01 15.0 0.0 1.2 1 0 0 1 1 1 1 Seadornavirus VP7 Glyco_hydro_18 PF00704.28 CCF49760.1 - 2e-08 34.3 0.0 8.9e-08 32.2 0.0 2.2 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 TMA7 PF09072.10 CCF49760.1 - 6.2 7.7 19.4 0.79 10.6 1.6 2.7 2 0 0 2 2 2 0 Translation machinery associated TMA7 zf-CCHC PF00098.23 CCF49761.1 - 0.00035 20.5 0.5 0.00081 19.4 0.5 1.7 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_6 PF15288.6 CCF49761.1 - 0.009 15.8 0.5 0.022 14.6 0.5 1.6 1 0 0 1 1 1 1 Zinc knuckle 2_5_RNA_ligase2 PF13563.6 CCF49761.1 - 0.017 15.0 0.1 0.027 14.4 0.1 1.3 1 0 0 1 1 1 0 2'-5' RNA ligase superfamily zf-CCHC_4 PF14392.6 CCF49761.1 - 0.17 11.6 0.2 0.33 10.7 0.2 1.5 1 0 0 1 1 1 0 Zinc knuckle MTP18 PF10558.9 CCF49762.1 - 7.4e-68 227.8 0.9 2.1e-67 226.3 0.9 1.7 1 1 0 1 1 1 1 Mitochondrial 18 KDa protein (MTP18) Pep3_Vps18 PF05131.14 CCF49763.1 - 7e-50 168.7 0.0 1.2e-49 167.9 0.0 1.4 1 0 0 1 1 1 1 Pep3/Vps18/deep orange family Clathrin PF00637.20 CCF49763.1 - 8.1e-11 42.0 2.0 1.6e-05 24.8 0.0 3.4 2 1 0 2 2 2 2 Region in Clathrin and VPS Vps39_2 PF10367.9 CCF49763.1 - 0.00063 20.2 0.1 0.0016 18.9 0.1 1.6 1 0 0 1 1 1 1 Vacuolar sorting protein 39 domain 2 zf-RING_5 PF14634.6 CCF49763.1 - 0.0076 16.2 3.0 0.0076 16.2 3.0 1.8 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 CCF49763.1 - 0.0085 15.9 4.9 0.0085 15.9 4.9 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) DUF2175 PF09943.9 CCF49763.1 - 0.086 13.1 0.0 0.32 11.3 0.0 2.0 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2175) Zn_ribbon_17 PF17120.5 CCF49763.1 - 0.098 12.3 1.6 0.19 11.4 1.6 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type Sbi-IV PF11621.8 CCF49763.1 - 0.21 12.0 0.5 2.1 8.8 0.0 2.7 3 0 0 3 3 3 0 C3 binding domain 4 of IgG-bind protein SBI zf-RING_11 PF17123.5 CCF49763.1 - 0.28 11.0 8.2 0.62 9.9 8.2 1.6 1 0 0 1 1 1 0 RING-like zinc finger zf-RING_2 PF13639.6 CCF49763.1 - 0.32 11.3 6.0 0.13 12.6 2.7 2.0 2 0 0 2 2 2 0 Ring finger domain Ribosomal_L2 PF00181.23 CCF49766.1 - 0.00068 19.6 0.0 0.0012 18.8 0.0 1.4 1 0 0 1 1 1 1 Ribosomal Proteins L2, RNA binding domain APOBEC4_like PF18774.1 CCF49769.1 - 0.039 13.9 0.0 0.062 13.2 0.0 1.4 1 1 0 1 1 1 0 APOBEC4-like -AID/APOBEC-deaminase rve PF00665.26 CCF49770.1 - 1.8e-09 37.8 0.0 3e-09 37.1 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain RVT_2 PF07727.14 CCF49770.1 - 0.0035 17.0 0.0 0.0052 16.4 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC PF00098.23 CCF49771.1 - 3.2e-06 27.0 1.4 3.2e-06 27.0 1.4 2.2 2 0 0 2 2 2 1 Zinc knuckle Ipi1_N PF12333.8 CCF49772.1 - 0.066 13.8 0.1 0.11 13.1 0.1 1.3 1 0 0 1 1 1 0 Rix1 complex component involved in 60S ribosome maturation ACR_tran PF00873.19 CCF49773.1 - 0.046 11.4 1.1 0.061 11.0 1.1 1.1 1 0 0 1 1 1 0 AcrB/AcrD/AcrF family HTH_37 PF13744.6 CCF49773.1 - 0.45 10.5 6.5 0.32 11.0 4.0 1.9 1 1 1 2 2 2 0 Helix-turn-helix domain Hydin_ADK PF17213.3 CCF49773.1 - 1.2 9.4 7.3 1.4 9.1 7.3 1.1 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain Penaeidin PF05927.11 CCF49774.1 - 0.019 15.7 0.0 0.085 13.6 0.0 2.1 1 1 1 2 2 2 0 Penaeidin Hamartin PF04388.12 CCF49776.1 - 0.046 12.4 6.8 0.052 12.2 6.8 1.0 1 0 0 1 1 1 0 Hamartin protein ETS_PEA3_N PF04621.13 CCF49776.1 - 0.089 12.7 3.1 0.095 12.6 3.1 1.1 1 0 0 1 1 1 0 PEA3 subfamily ETS-domain transcription factor N terminal domain DDE_3 PF13358.6 CCF49779.1 - 3.5e-08 33.3 0.6 8.3e-08 32.1 0.6 1.8 1 1 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc3_2 PF01498.18 CCF49779.1 - 1.6e-07 31.5 2.4 3.2e-07 30.5 1.9 1.8 2 0 0 2 2 2 1 Transposase HTH_23 PF13384.6 CCF49779.1 - 0.00069 19.3 0.0 0.0028 17.4 0.0 2.1 2 0 0 2 2 2 1 Homeodomain-like domain HTH_29 PF13551.6 CCF49779.1 - 0.021 14.9 0.0 0.066 13.2 0.0 1.9 2 0 0 2 2 2 0 Winged helix-turn helix Prolamin_like PF05617.11 CCF49779.1 - 0.045 13.9 2.1 6.1 7.1 0.1 2.6 2 0 0 2 2 2 0 Prolamin-like GerE PF00196.19 CCF49779.1 - 0.046 13.3 0.1 0.29 10.7 0.0 2.2 2 0 0 2 2 2 0 Bacterial regulatory proteins, luxR family HTH_38 PF13936.6 CCF49779.1 - 0.049 13.4 0.0 0.16 11.8 0.0 1.9 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_32 PF13565.6 CCF49779.1 - 0.053 14.1 0.0 0.17 12.5 0.0 1.9 2 1 0 2 2 2 0 Homeodomain-like domain DDE_3 PF13358.6 CCF49781.1 - 2.7e-08 33.7 0.5 5.6e-08 32.7 0.5 1.7 1 1 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc3_2 PF01498.18 CCF49781.1 - 4.3e-08 33.3 1.6 9.2e-08 32.2 1.2 1.8 2 0 0 2 2 2 1 Transposase Prolamin_like PF05617.11 CCF49781.1 - 0.087 13.0 3.3 4.8 7.4 0.1 2.6 2 0 0 2 2 2 0 Prolamin-like STT3 PF02516.14 CCF49782.1 - 1.3e-140 469.6 37.9 1.2e-137 459.9 37.9 2.1 1 1 0 1 1 1 1 Oligosaccharyl transferase STT3 subunit Tetraspanin PF00335.20 CCF49782.1 - 2.3 7.9 0.0 2.3 7.9 0.0 3.0 3 0 0 3 3 3 0 Tetraspanin family RVT_1 PF00078.27 CCF49783.1 - 9.7e-31 107.0 0.0 1.7e-30 106.2 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 CCF49783.1 - 5.7e-28 96.9 0.0 1.8e-27 95.3 0.0 1.9 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 CCF49783.1 - 5.5e-19 68.0 0.4 1.1e-18 67.0 0.4 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain RT_RNaseH PF17917.1 CCF49783.1 - 4e-18 65.6 0.0 1.1e-17 64.2 0.0 1.8 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 CCF49783.1 - 4.2e-15 56.0 0.0 9.1e-15 54.9 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Chromo PF00385.24 CCF49783.1 - 3.3e-12 46.1 1.1 7.2e-12 45.0 0.2 2.2 2 0 0 2 2 2 1 Chromo (CHRromatin Organisation MOdifier) domain rve_3 PF13683.6 CCF49783.1 - 0.26 11.1 1.0 0.57 10.0 0.0 2.1 2 0 0 2 2 2 0 Integrase core domain NPV_P10 PF05531.12 CCF49786.1 - 0.12 12.8 0.0 0.39 11.2 0.0 1.7 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein RVT_2 PF07727.14 CCF49788.1 - 2e-50 171.7 0.4 1e-49 169.4 0.0 2.1 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 CCF49788.1 - 5.8e-11 42.6 0.0 1.1e-10 41.8 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain zf-CCHC PF00098.23 CCF49788.1 - 4.1e-05 23.5 3.1 8.7e-05 22.4 3.1 1.6 1 0 0 1 1 1 1 Zinc knuckle RT_RNaseH PF17917.1 CCF49792.1 - 4.8e-36 123.2 0.4 1.1e-35 122.1 0.1 1.8 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 CCF49792.1 - 1.1e-32 112.0 0.0 3e-32 110.6 0.0 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 CCF49792.1 - 1.4e-28 100.0 0.0 2.6e-28 99.0 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 CCF49792.1 - 1.7e-18 66.4 0.4 1.7e-18 66.4 0.4 1.8 2 0 0 2 2 2 1 Integrase zinc binding domain rve PF00665.26 CCF49792.1 - 4.6e-15 55.8 0.0 1.5e-14 54.2 0.0 2.0 1 0 0 1 1 1 1 Integrase core domain Chromo PF00385.24 CCF49792.1 - 2.1e-11 43.5 0.2 7.2e-11 41.8 0.2 2.0 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain zf-CCHC PF00098.23 CCF49792.1 - 1.8e-05 24.6 2.1 5e-05 23.2 2.1 1.8 1 0 0 1 1 1 1 Zinc knuckle Retrotrans_gag PF03732.17 CCF49792.1 - 0.004 17.4 1.0 0.013 15.8 0.1 2.4 2 0 0 2 2 2 1 Retrotransposon gag protein zf-CCHC_2 PF13696.6 CCF49792.1 - 0.033 14.0 3.5 0.061 13.2 3.5 1.5 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_5 PF14787.6 CCF49792.1 - 0.17 11.6 2.0 0.49 10.1 1.7 1.9 2 0 0 2 2 2 0 GAG-polyprotein viral zinc-finger Tubulin PF00091.25 CCF49796.1 - 8.9e-61 205.5 0.0 1.3e-60 204.9 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 CCF49796.1 - 9.5e-37 126.0 0.0 1.4e-36 125.4 0.0 1.2 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 CCF49796.1 - 0.00049 19.8 0.0 0.00084 19.1 0.0 1.3 1 0 0 1 1 1 1 Tubulin domain Tubulin_2 PF13809.6 CCF49796.1 - 0.0014 17.9 0.0 0.0028 16.9 0.0 1.4 1 0 0 1 1 1 1 Tubulin like Misat_Tub_SegII PF10644.9 CCF49796.1 - 0.0057 17.0 0.0 0.012 15.9 0.0 1.5 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain RecT PF03837.14 CCF49796.1 - 0.035 13.6 0.3 0.061 12.8 0.3 1.3 1 0 0 1 1 1 0 RecT family MS_channel PF00924.18 CCF49797.1 - 3.5e-19 69.2 1.4 5.8e-19 68.5 1.4 1.3 1 0 0 1 1 1 1 Mechanosensitive ion channel EF-hand_1 PF00036.32 CCF49797.1 - 1e-05 24.7 0.1 2.2e-05 23.7 0.1 1.6 1 0 0 1 1 1 1 EF hand EF-hand_5 PF13202.6 CCF49797.1 - 0.0003 20.2 0.2 0.00073 18.9 0.2 1.6 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 CCF49797.1 - 0.00034 20.3 0.0 0.0008 19.1 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain EF-hand_7 PF13499.6 CCF49797.1 - 0.00042 20.7 0.1 0.00095 19.6 0.1 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.6 CCF49797.1 - 0.0038 17.0 0.2 0.0081 16.0 0.2 1.5 1 0 0 1 1 1 1 EF-hand domain pair NARG2_C PF10505.9 CCF49797.1 - 0.006 16.1 0.1 0.011 15.3 0.1 1.3 1 0 0 1 1 1 1 NMDA receptor-regulated gene protein 2 C-terminus PBP1_TM PF14812.6 CCF49797.1 - 0.015 15.7 0.4 0.046 14.1 0.4 1.8 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal SDP_N PF12278.8 CCF49797.1 - 0.045 13.9 5.4 0.15 12.2 4.7 2.2 2 0 0 2 2 2 0 Sex determination protein N terminal DUF1576 PF07613.11 CCF49797.1 - 0.52 9.8 4.7 0.1 12.1 0.5 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1576) VIT1 PF01988.19 CCF49797.1 - 0.61 9.9 11.8 5.5 6.8 4.6 3.3 2 2 0 2 2 2 0 VIT family DUF2207 PF09972.9 CCF49797.1 - 7 5.3 11.4 0.28 9.9 0.5 2.9 3 1 0 3 3 3 0 Predicted membrane protein (DUF2207) SRF-TF PF00319.18 CCF49798.1 - 1.9e-21 75.2 0.1 5.6e-21 73.8 0.0 1.8 2 0 0 2 2 2 1 SRF-type transcription factor (DNA-binding and dimerisation domain) Sortilin-Vps10 PF15902.5 CCF49799.1 - 8.2e-284 941.1 5.5 4.8e-151 503.5 0.3 2.4 3 0 0 3 3 3 2 Sortilin, neurotensin receptor 3, Sortilin_C PF15901.5 CCF49799.1 - 8.6e-92 306.1 17.1 1.5e-47 162.1 8.0 2.5 2 0 0 2 2 2 2 Sortilin, neurotensin receptor 3, C-terminal BNR PF02012.20 CCF49799.1 - 9.2e-08 31.0 44.9 1.6 9.1 0.7 12.2 12 0 0 12 12 12 5 BNR/Asp-box repeat Fe_dep_repr_C PF02742.15 CCF49799.1 - 0.02 14.9 0.0 0.12 12.5 0.0 2.2 2 0 0 2 2 2 0 Iron dependent repressor, metal binding and dimerisation domain BNR_6 PF15899.5 CCF49799.1 - 0.056 13.5 9.8 1.4 9.2 0.4 4.3 3 0 0 3 3 3 0 BNR-Asp box repeat PSII_BNR PF14870.6 CCF49799.1 - 0.1 11.8 2.9 3.3 6.9 0.1 4.1 4 0 0 4 4 4 0 Photosynthesis system II assembly factor YCF48 RA PF00788.23 CCF49800.1 - 0.081 13.6 0.0 0.17 12.5 0.0 1.5 1 0 0 1 1 1 0 Ras association (RalGDS/AF-6) domain DUF4449 PF14613.6 CCF49801.1 - 1.6e-28 99.9 5.4 5.1e-18 65.7 1.1 4.4 2 2 2 4 4 4 2 Protein of unknown function (DUF4449) Sec7 PF01369.20 CCF49802.1 - 4.6e-33 114.4 0.0 6.7e-33 113.9 0.0 1.2 1 0 0 1 1 1 1 Sec7 domain SET PF00856.28 CCF49803.1 - 5.2e-17 62.7 0.0 1.1e-16 61.7 0.0 1.6 1 0 0 1 1 1 1 SET domain Pre-SET PF05033.16 CCF49803.1 - 1.7e-11 44.7 0.9 1.7e-11 44.7 0.9 2.2 2 0 0 2 2 2 1 Pre-SET motif AWS PF17907.1 CCF49803.1 - 0.0032 17.5 2.8 0.0032 17.5 2.8 2.8 3 0 0 3 3 3 1 AWS domain Macoilin PF09726.9 CCF49803.1 - 1.4 7.4 4.9 2.4 6.6 4.9 1.3 1 0 0 1 1 1 0 Macoilin family CSRNP_N PF16019.5 CCF49803.1 - 2 8.2 9.2 0.38 10.7 5.0 1.9 2 0 0 2 2 2 0 Cysteine/serine-rich nuclear protein N-terminus NAD_binding_8 PF13450.6 CCF49804.1 - 3.9e-11 43.0 0.0 9.2e-11 41.8 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CCF49804.1 - 0.00038 19.8 0.0 0.051 12.8 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 CCF49804.1 - 0.0042 16.4 0.0 0.0072 15.6 0.0 1.3 1 0 0 1 1 1 1 Thi4 family HI0933_like PF03486.14 CCF49804.1 - 0.007 15.1 0.1 0.041 12.6 0.0 2.0 2 0 0 2 2 2 1 HI0933-like protein DAO PF01266.24 CCF49804.1 - 0.0096 15.5 0.0 0.063 12.8 0.0 2.0 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 CCF49804.1 - 0.077 12.2 0.0 3.2 6.9 0.0 2.6 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 CCF49804.1 - 0.14 11.2 0.0 0.21 10.6 0.0 1.2 1 0 0 1 1 1 0 FAD binding domain FMO-like PF00743.19 CCF49805.1 - 1e-32 113.3 0.0 5.4e-11 41.6 0.1 3.2 3 0 0 3 3 3 3 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 CCF49805.1 - 1e-10 41.4 0.0 0.00028 20.2 0.0 3.6 3 1 0 3 3 3 3 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 CCF49805.1 - 3.4e-10 39.6 0.0 1.1e-09 37.9 0.0 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 CCF49805.1 - 3.2e-07 29.8 0.1 0.019 14.1 0.0 4.0 4 0 0 4 4 4 2 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 CCF49805.1 - 2.1e-06 27.9 0.1 8.3e-05 22.7 0.0 2.6 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 CCF49805.1 - 7.3e-06 26.0 0.0 4.3e-05 23.6 0.0 2.4 2 1 0 2 2 2 1 FAD-NAD(P)-binding Pyr_redox PF00070.27 CCF49805.1 - 0.0029 18.1 0.1 0.64 10.6 0.1 2.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Shikimate_DH PF01488.20 CCF49805.1 - 0.022 14.8 0.0 0.84 9.7 0.0 2.4 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase DAO PF01266.24 CCF49805.1 - 0.03 13.9 0.0 0.29 10.7 0.0 2.5 2 0 0 2 2 2 0 FAD dependent oxidoreductase Thi4 PF01946.17 CCF49805.1 - 0.12 11.6 0.0 7.6 5.7 0.0 2.5 2 0 0 2 2 2 0 Thi4 family NAD_binding_7 PF13241.6 CCF49805.1 - 0.17 12.4 0.0 7.2 7.1 0.0 2.5 2 0 0 2 2 2 0 Putative NAD(P)-binding SYS1 PF09801.9 CCF49807.1 - 4.5e-22 78.8 7.1 5.6e-17 62.2 4.2 2.1 2 0 0 2 2 2 2 Integral membrane protein S linking to the trans Golgi network zf-RING_2 PF13639.6 CCF49808.1 - 1.8e-10 41.0 1.8 3.5e-10 40.1 1.8 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 CCF49808.1 - 2.9e-08 33.3 0.4 5.9e-08 32.3 0.4 1.6 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_UBOX PF13445.6 CCF49808.1 - 3.1e-08 33.5 0.7 7.9e-08 32.2 0.7 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 CCF49808.1 - 4.5e-08 32.8 0.6 8.2e-08 32.0 0.6 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CCF49808.1 - 2.7e-06 27.2 0.8 4.8e-06 26.4 0.8 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-rbx1 PF12678.7 CCF49808.1 - 0.00058 20.1 3.9 0.00058 20.1 3.9 2.1 2 1 0 2 2 1 1 RING-H2 zinc finger domain FANCL_C PF11793.8 CCF49808.1 - 0.0011 19.1 1.2 0.0021 18.2 1.2 1.5 1 0 0 1 1 1 1 FANCL C-terminal domain zf-C3HC4_2 PF13923.6 CCF49808.1 - 0.0025 17.6 3.7 0.025 14.4 3.7 2.4 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 CCF49808.1 - 0.0051 16.4 0.1 0.013 15.1 0.1 1.6 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type TetR PF13972.6 CCF49808.1 - 0.0085 15.8 0.4 0.024 14.4 0.4 1.7 1 0 0 1 1 1 1 Bacterial transcriptional repressor zf-C3HC4_3 PF13920.6 CCF49808.1 - 0.017 15.0 0.5 0.039 13.8 0.5 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 CCF49808.1 - 0.032 14.1 5.5 0.11 12.3 5.5 2.0 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 RINGv PF12906.7 CCF49808.1 - 0.048 13.8 1.8 0.12 12.5 1.8 1.8 1 0 0 1 1 1 0 RING-variant domain zf-C3HC4_4 PF15227.6 CCF49808.1 - 0.076 13.2 1.2 0.27 11.4 1.2 2.0 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-ANAPC11 PF12861.7 CCF49808.1 - 0.22 11.6 0.4 0.47 10.5 0.4 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger RcpB PF16971.5 CCF49808.1 - 3 7.7 7.8 6.8 6.6 4.6 2.8 2 1 0 2 2 2 0 Rough colony protein B, tight adherence - tad - subunit THOC7 PF05615.13 CCF49808.1 - 10 6.4 26.8 0.052 13.8 8.7 3.4 1 1 2 3 3 3 0 Tho complex subunit 7 Ribonuc_P_40 PF08584.11 CCF49809.1 - 1.2e-30 106.8 0.0 3.5e-30 105.3 0.0 1.8 1 1 0 1 1 1 1 Ribonuclease P 40kDa (Rpp40) subunit DUF5444 PF17519.2 CCF49809.1 - 0.12 12.4 0.2 11 6.1 0.1 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5444) SHS2_Rpb7-N PF03876.17 CCF49810.1 - 1.1e-12 48.2 0.0 1.6e-12 47.6 0.0 1.3 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 S1 PF00575.23 CCF49810.1 - 2.1e-12 47.2 0.1 4e-12 46.3 0.1 1.4 1 0 0 1 1 1 1 S1 RNA binding domain RNA_pol_Rbc25 PF08292.12 CCF49810.1 - 0.043 14.0 0.0 0.064 13.5 0.0 1.4 1 0 0 1 1 1 0 RNA polymerase III subunit Rpc25 Rtf2 PF04641.12 CCF49811.1 - 1.4e-72 244.3 1.4 1.7e-72 243.9 1.4 1.1 1 0 0 1 1 1 1 Rtf2 RING-finger zf-C2HC_2 PF13913.6 CCF49811.1 - 0.0022 17.8 0.1 0.0074 16.2 0.1 1.9 2 0 0 2 2 2 1 zinc-finger of a C2HC-type zf-Nse PF11789.8 CCF49811.1 - 0.019 14.8 1.4 0.58 10.0 0.0 2.9 2 1 0 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit zf-NOSIP PF15906.5 CCF49811.1 - 0.037 14.2 0.0 0.079 13.1 0.0 1.5 1 0 0 1 1 1 0 Zinc-finger of nitric oxide synthase-interacting protein Zn-C2H2_12 PF18112.1 CCF49811.1 - 0.23 12.0 0.2 0.23 12.0 0.2 2.1 3 0 0 3 3 3 0 Autophagy receptor zinc finger-C2H2 domain zf-C2H2_4 PF13894.6 CCF49811.1 - 0.48 11.4 6.3 7.3 7.7 0.1 3.5 3 0 0 3 3 3 0 C2H2-type zinc finger Vps39_2 PF10367.9 CCF49811.1 - 1 9.8 3.2 37 4.8 0.0 2.4 2 0 0 2 2 2 0 Vacuolar sorting protein 39 domain 2 zinc_ribbon_15 PF17032.5 CCF49811.1 - 1.1 10.0 5.4 6.9 7.5 0.2 2.4 2 0 0 2 2 2 0 zinc-ribbon family RNA_polI_A34 PF08208.11 CCF49811.1 - 1.5 8.8 14.1 3 7.9 14.1 1.4 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 RR_TM4-6 PF06459.12 CCF49811.1 - 2.5 7.8 9.4 3.3 7.5 9.4 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 SH3_9 PF14604.6 CCF49813.1 - 3.8e-38 129.1 13.6 3.6e-14 52.4 0.1 4.4 4 1 0 4 4 4 3 Variant SH3 domain SH3_1 PF00018.28 CCF49813.1 - 1.7e-37 126.7 11.3 5.1e-16 58.0 0.3 4.5 4 0 0 4 4 4 3 SH3 domain SHD1 PF03983.12 CCF49813.1 - 4.6e-32 109.7 0.0 9.4e-32 108.7 0.0 1.6 1 0 0 1 1 1 1 SLA1 homology domain 1, SHD1 SH3_2 PF07653.17 CCF49813.1 - 1.4e-24 85.5 0.0 3.2e-07 29.9 0.0 4.5 4 0 0 4 4 4 4 Variant SH3 domain SAM_4 PF18017.1 CCF49813.1 - 3.1e-05 23.8 0.0 7e-05 22.7 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SH3_3 PF08239.11 CCF49813.1 - 0.00034 20.8 3.6 0.0049 17.1 0.2 3.0 3 0 0 3 3 3 1 Bacterial SH3 domain DUF1720 PF08226.11 CCF49813.1 - 0.0036 17.7 43.7 0.0036 17.7 43.7 5.7 4 2 2 6 6 6 2 Domain of unknown function (DUF1720) SH3_10 PF17902.1 CCF49813.1 - 0.0062 16.6 0.5 0.051 13.6 0.0 2.8 3 0 0 3 3 3 1 SH3 domain Ank_4 PF13637.6 CCF49814.1 - 7.5e-10 39.2 0.5 0.00037 21.0 0.1 2.6 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 CCF49814.1 - 1.9e-07 31.5 1.0 0.03 14.9 0.1 3.3 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 CCF49814.1 - 2.2e-06 27.5 1.4 0.068 13.8 0.0 4.3 4 0 0 4 4 4 2 Ankyrin repeat KilA-N PF04383.13 CCF49814.1 - 2.1e-05 24.3 0.1 0.00035 20.4 0.1 2.4 1 1 0 1 1 1 1 KilA-N domain Ank_5 PF13857.6 CCF49814.1 - 0.00022 21.5 5.6 0.11 12.9 0.0 4.3 3 1 1 4 4 4 1 Ankyrin repeats (many copies) Ank PF00023.30 CCF49814.1 - 0.00022 21.5 5.7 0.44 11.1 0.2 4.3 4 0 0 4 4 4 2 Ankyrin repeat OmpH PF03938.14 CCF49814.1 - 0.038 14.3 6.1 0.11 12.8 6.1 1.7 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF641 PF04859.12 CCF49814.1 - 0.075 13.4 3.9 0.059 13.7 1.6 2.0 2 0 0 2 2 1 0 Plant protein of unknown function (DUF641) DUF5340 PF17275.2 CCF49814.1 - 0.17 12.1 5.4 0.08 13.1 1.9 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5340) Filament PF00038.21 CCF49814.1 - 0.17 11.4 10.3 0.2 11.2 9.2 1.5 1 1 0 1 1 1 0 Intermediate filament protein Fib_alpha PF08702.10 CCF49814.1 - 1.5 9.0 10.8 5.8 7.1 3.7 2.5 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Exonuc_VII_L PF02601.15 CCF49814.1 - 3.2 7.2 9.7 0.87 9.1 6.2 1.7 2 0 0 2 2 2 0 Exonuclease VII, large subunit Spc7 PF08317.11 CCF49814.1 - 3.3 6.5 11.8 0.4 9.5 7.2 1.7 2 0 0 2 2 2 0 Spc7 kinetochore protein HIP1_clath_bdg PF16515.5 CCF49814.1 - 3.4 8.3 12.0 9.5 6.9 5.5 2.8 2 1 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 AAA_13 PF13166.6 CCF49814.1 - 7.6 5.0 12.4 0.26 9.9 6.5 1.4 2 0 0 2 2 2 0 AAA domain His_Phos_1 PF00300.22 CCF49815.1 - 4.2e-38 131.0 0.0 4.8e-38 130.8 0.0 1.0 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) SH3_9 PF14604.6 CCF49816.1 - 2.1e-29 101.1 1.0 2e-15 56.4 0.1 2.4 2 0 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.28 CCF49816.1 - 8.2e-27 92.6 3.1 5.3e-15 54.8 0.1 2.4 2 0 0 2 2 2 2 SH3 domain Cofilin_ADF PF00241.20 CCF49816.1 - 3.5e-20 72.0 0.0 6.2e-20 71.2 0.0 1.4 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein SH3_2 PF07653.17 CCF49816.1 - 4.1e-17 61.6 0.2 9.9e-09 34.8 0.0 2.4 2 0 0 2 2 2 2 Variant SH3 domain RhoGAP PF00620.27 CCF49817.1 - 1.9e-36 125.2 0.1 3.9e-36 124.2 0.1 1.5 1 0 0 1 1 1 1 RhoGAP domain LIM PF00412.22 CCF49817.1 - 3.8e-26 91.1 32.5 7.8e-11 42.0 2.8 4.9 5 0 0 5 5 5 4 LIM domain CD20 PF04103.15 CCF49818.1 - 0.0051 16.9 0.9 0.0051 16.9 0.9 2.3 1 1 2 3 3 3 1 CD20-like family MEKHLA PF08670.11 CCF49818.1 - 0.099 12.5 0.0 0.16 11.8 0.0 1.3 1 0 0 1 1 1 0 MEKHLA domain DUF5084 PF16894.5 CCF49818.1 - 1.7 9.1 3.7 1.4 9.3 0.4 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF5084) DUF1917 PF08939.10 CCF49819.1 - 0.19 11.6 0.0 0.19 11.6 0.0 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF1917) DUF2235 PF09994.9 CCF49820.1 - 7.3e-67 225.7 0.0 1.6e-65 221.3 0.0 2.2 2 0 0 2 2 2 2 Uncharacterized alpha/beta hydrolase domain (DUF2235) zf-CCCH PF00642.24 CCF49821.1 - 5.1e-12 45.4 25.3 9.2e-08 31.8 1.2 4.5 3 1 1 4 4 4 3 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 CCF49821.1 - 6.2e-05 22.9 35.3 0.014 15.4 2.6 4.7 5 0 0 5 5 5 3 Zinc finger domain Torus PF16131.5 CCF49821.1 - 0.0016 19.1 20.6 0.016 15.9 0.1 4.5 3 1 2 5 5 5 3 Torus domain zf-CCCH_4 PF18044.1 CCF49821.1 - 0.012 15.4 0.9 0.012 15.4 0.9 4.5 5 0 0 5 5 5 0 CCCH-type zinc finger MFS_1 PF07690.16 CCF49822.1 - 2.4e-14 53.0 31.6 2.4e-14 53.0 31.6 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily UNC-93 PF05978.16 CCF49822.1 - 8.9e-14 51.5 11.1 3.6e-13 49.5 9.2 2.3 2 0 0 2 2 2 1 Ion channel regulatory protein UNC-93 Amidohydro_3 PF07969.11 CCF49823.1 - 2.1e-15 57.2 2.7 1.7e-06 27.8 0.0 3.3 3 0 0 3 3 3 2 Amidohydrolase family Amidohydro_1 PF01979.20 CCF49823.1 - 1.3e-09 37.8 0.1 1.3e-05 24.7 0.0 2.5 2 0 0 2 2 2 2 Amidohydrolase family Prenyltrans PF00432.21 CCF49824.1 - 1.8e-27 94.7 8.3 3e-06 26.9 0.0 6.4 5 1 0 5 5 5 5 Prenyltransferase and squalene oxidase repeat SQHop_cyclase_N PF13249.6 CCF49824.1 - 0.0053 15.9 0.0 1.6 7.7 0.0 2.3 2 0 0 2 2 2 2 Squalene-hopene cyclase N-terminal domain DUF4451 PF14616.6 CCF49825.1 - 2e-18 66.7 1.1 6.3e-18 65.1 1.1 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF4451) Thioredoxin PF00085.20 CCF49826.1 - 4.9e-26 90.7 0.0 2.1e-25 88.7 0.0 2.2 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 CCF49826.1 - 2.5e-06 27.9 0.2 1.5e-05 25.4 0.1 2.4 1 1 1 2 2 2 1 Thioredoxin-like domain OST3_OST6 PF04756.13 CCF49826.1 - 3.8e-05 23.2 0.0 0.0011 18.4 0.0 2.2 2 0 0 2 2 2 1 OST3 / OST6 family, transporter family Thioredoxin_7 PF13899.6 CCF49826.1 - 0.01 16.0 0.0 0.03 14.5 0.0 1.9 1 0 0 1 1 1 0 Thioredoxin-like DUF755 PF05501.11 CCF49826.1 - 0.016 15.5 8.7 0.016 15.5 8.7 2.4 2 0 0 2 2 1 0 Domain of unknown function (DUF755) Thioredoxin_8 PF13905.6 CCF49826.1 - 0.016 15.5 0.0 0.11 12.8 0.0 2.4 1 1 1 2 2 2 0 Thioredoxin-like AhpC-TSA PF00578.21 CCF49826.1 - 0.022 14.6 0.3 0.09 12.7 0.0 2.2 2 1 2 4 4 4 0 AhpC/TSA family Thioredoxin_9 PF14595.6 CCF49826.1 - 0.025 14.3 2.4 0.042 13.6 0.0 2.5 3 0 0 3 3 3 0 Thioredoxin FtsK_SpoIIIE PF01580.18 CCF49826.1 - 0.14 11.5 0.2 0.37 10.1 0.2 1.7 1 0 0 1 1 1 0 FtsK/SpoIIIE family TSP_NTD PF17804.1 CCF49826.1 - 0.58 10.4 5.8 0.32 11.2 0.6 2.6 2 1 0 2 2 2 0 Tail specific protease N-terminal domain Casc1 PF12366.8 CCF49826.1 - 5 6.6 9.5 0.11 12.0 1.6 2.1 2 0 0 2 2 2 0 Cancer susceptibility candidate 1 PPR_2 PF13041.6 CCF49827.1 - 0.00094 19.3 0.0 15 5.8 0.0 4.8 6 0 0 6 6 6 2 PPR repeat family PPR PF01535.20 CCF49827.1 - 0.016 15.4 0.3 1.9e+02 2.6 0.0 5.2 5 0 0 5 5 5 0 PPR repeat TPR_12 PF13424.6 CCF49827.1 - 0.16 12.2 8.2 0.78 10.1 2.4 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat PPR_1 PF12854.7 CCF49827.1 - 0.2 11.4 0.0 64 3.4 0.1 4.0 4 0 0 4 4 4 0 PPR repeat Methyltransf_11 PF08241.12 CCF49828.1 - 1.1e-15 58.0 0.1 1.8e-15 57.4 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCF49828.1 - 2.5e-15 56.7 0.1 3.2e-15 56.4 0.1 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF49828.1 - 1.8e-14 54.2 0.1 3.2e-14 53.4 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF49828.1 - 5.9e-14 52.6 0.1 9.6e-14 51.9 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF49828.1 - 1.3e-10 41.3 0.1 2.1e-10 40.6 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_9 PF08003.11 CCF49828.1 - 3.1e-07 29.6 0.1 4.2e-07 29.2 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) Methyltransf_16 PF10294.9 CCF49828.1 - 3.5e-07 30.1 0.1 4.7e-07 29.7 0.1 1.2 1 0 0 1 1 1 1 Lysine methyltransferase MTS PF05175.14 CCF49828.1 - 2.3e-06 27.3 0.1 3.2e-06 26.8 0.1 1.2 1 0 0 1 1 1 1 Methyltransferase small domain RrnaAD PF00398.20 CCF49828.1 - 7.8e-05 21.9 0.0 0.00019 20.6 0.0 1.5 1 1 1 2 2 2 1 Ribosomal RNA adenine dimethylase Ubie_methyltran PF01209.18 CCF49828.1 - 0.00016 21.1 0.1 0.0011 18.4 0.0 1.9 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family PrmA PF06325.13 CCF49828.1 - 0.00017 21.1 0.1 0.00024 20.6 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) tRNA_U5-meth_tr PF05958.11 CCF49828.1 - 0.00064 18.8 0.1 0.0013 17.8 0.0 1.5 2 0 0 2 2 2 1 tRNA (Uracil-5-)-methyltransferase NodS PF05401.11 CCF49828.1 - 0.0017 18.0 0.0 0.0025 17.5 0.0 1.2 1 0 0 1 1 1 1 Nodulation protein S (NodS) CMAS PF02353.20 CCF49828.1 - 0.0081 15.5 0.1 0.011 15.1 0.1 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase TehB PF03848.14 CCF49828.1 - 0.011 15.2 0.0 0.015 14.7 0.0 1.1 1 0 0 1 1 1 0 Tellurite resistance protein TehB DREV PF05219.12 CCF49828.1 - 0.028 13.5 0.0 0.052 12.6 0.0 1.4 1 0 0 1 1 1 0 DREV methyltransferase Methyltransf_18 PF12847.7 CCF49828.1 - 0.052 13.5 0.0 0.083 12.8 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_32 PF13679.6 CCF49828.1 - 0.068 13.2 0.0 0.15 12.0 0.0 1.4 1 1 0 1 1 1 0 Methyltransferase domain PCMT PF01135.19 CCF49828.1 - 0.073 12.8 0.0 0.098 12.4 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_4 PF02390.17 CCF49828.1 - 0.088 12.3 0.1 0.26 10.7 0.1 1.7 2 0 0 2 2 2 0 Putative methyltransferase MBOAT PF03062.19 CCF49829.1 - 2.8e-36 125.6 18.4 7.2e-36 124.2 18.4 1.7 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family MBOAT_2 PF13813.6 CCF49829.1 - 0.00072 19.8 3.0 0.0026 18.0 3.0 1.9 1 0 0 1 1 1 1 Membrane bound O-acyl transferase family PRP1_N PF06424.12 CCF49829.1 - 0.041 14.3 11.0 0.1 13.0 11.0 1.6 1 0 0 1 1 1 0 PRP1 splicing factor, N-terminal DDHD PF02862.17 CCF49829.1 - 0.19 11.8 2.5 0.36 10.9 2.5 1.5 1 0 0 1 1 1 0 DDHD domain GREB1 PF15782.5 CCF49829.1 - 1.8 5.6 8.1 2.3 5.2 8.1 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer HSP70 PF00012.20 CCF49831.1 - 2.3e-74 250.7 1.2 1.8e-73 247.8 0.2 2.1 2 0 0 2 2 2 1 Hsp70 protein MreB_Mbl PF06723.13 CCF49831.1 - 1.9e-06 26.9 0.7 8.1e-06 24.9 0.2 1.9 2 0 0 2 2 2 1 MreB/Mbl protein US30 PF17624.2 CCF49831.1 - 0.0073 15.4 0.0 0.038 13.0 0.0 2.0 2 0 0 2 2 2 1 Family of unknown function Actin PF00022.19 CCF49831.1 - 0.013 14.1 0.0 2.3 6.8 0.0 2.1 2 0 0 2 2 2 0 Actin Hydantoinase_A PF01968.18 CCF49831.1 - 0.02 14.1 0.5 0.043 13.1 0.1 1.8 2 0 0 2 2 2 0 Hydantoinase/oxoprolinase FtsA PF14450.6 CCF49831.1 - 0.04 14.3 0.4 0.22 12.0 0.2 2.3 2 1 0 2 2 2 0 Cell division protein FtsA PilM_2 PF11104.8 CCF49831.1 - 0.058 12.4 0.1 1.8 7.5 0.0 2.3 2 0 0 2 2 2 0 Type IV pilus assembly protein PilM; RNase_H2_suC PF08615.11 CCF49832.1 - 8.6e-17 61.6 0.0 2.2e-16 60.3 0.0 1.6 1 1 0 1 1 1 1 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) Red1 PF07964.11 CCF49832.1 - 0.14 10.4 4.1 0.18 10.0 4.1 1.0 1 0 0 1 1 1 0 Rec10 / Red1 F-protein PF00469.20 CCF49832.1 - 0.53 9.8 3.3 0.9 9.1 3.3 1.3 1 0 0 1 1 1 0 Negative factor, (F-Protein) or Nef Presenilin PF01080.17 CCF49832.1 - 4.9 5.8 5.5 6.7 5.4 5.5 1.1 1 0 0 1 1 1 0 Presenilin Hid1 PF12722.7 CCF49832.1 - 5.9 4.9 4.8 7.2 4.6 4.8 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Abhydrolase_2 PF02230.16 CCF49833.1 - 5.8e-18 65.5 0.2 8.2e-18 65.0 0.2 1.2 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Abhydrolase_3 PF07859.13 CCF49833.1 - 0.014 15.2 0.0 0.02 14.7 0.0 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold FSH1 PF03959.13 CCF49833.1 - 0.17 11.5 0.0 0.39 10.3 0.0 1.6 1 1 0 1 1 1 0 Serine hydrolase (FSH1) Lipase PF00151.19 CCF49833.1 - 0.23 10.7 0.0 0.33 10.2 0.0 1.1 1 0 0 1 1 1 0 Lipase ThiS PF02597.20 CCF49834.1 - 3e-06 27.8 0.0 3.5e-06 27.6 0.0 1.1 1 0 0 1 1 1 1 ThiS family TPR_1 PF00515.28 CCF49835.1 - 1.8e-23 81.3 0.0 1.9e-08 33.7 0.0 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 CCF49835.1 - 3e-18 64.4 0.0 2e-06 27.5 0.0 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 CCF49835.1 - 8.5e-17 60.6 0.2 2.8e-05 23.7 0.0 3.4 1 1 2 3 3 3 3 TPR repeat TPR_8 PF13181.6 CCF49835.1 - 1.2e-14 53.2 0.5 9e-05 22.4 0.0 4.1 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_14 PF13428.6 CCF49835.1 - 1e-10 41.5 0.1 0.00012 22.6 0.0 3.7 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 CCF49835.1 - 2.1e-08 34.0 0.0 0.0042 17.4 0.0 3.2 3 0 0 3 3 2 2 Tetratricopeptide repeat SGTA_dimer PF16546.5 CCF49835.1 - 5.2e-08 32.5 0.0 1.2e-07 31.4 0.0 1.6 1 0 0 1 1 1 1 Homodimerisation domain of SGTA TPR_19 PF14559.6 CCF49835.1 - 6.7e-08 32.9 0.1 2.7e-05 24.6 0.0 2.8 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.6 CCF49835.1 - 2.7e-07 31.1 1.0 0.0011 19.6 0.1 3.4 2 1 1 3 3 3 2 Tetratricopeptide repeat BTAD PF03704.17 CCF49835.1 - 1e-06 29.2 0.1 0.00035 21.0 0.0 2.4 2 0 0 2 2 2 1 Bacterial transcriptional activator domain TPR_12 PF13424.6 CCF49835.1 - 5e-06 26.7 0.1 0.14 12.5 0.2 2.9 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.6 CCF49835.1 - 7.1e-06 25.7 0.0 0.02 14.9 0.0 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_10 PF13374.6 CCF49835.1 - 9.5e-05 22.1 0.2 0.11 12.4 0.0 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_9 PF13371.6 CCF49835.1 - 0.0035 17.5 0.0 0.2 11.8 0.0 2.4 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_15 PF13429.6 CCF49835.1 - 0.0085 15.3 1.4 0.0089 15.3 0.2 1.8 2 0 0 2 2 2 1 Tetratricopeptide repeat Alkyl_sulf_dimr PF14863.6 CCF49835.1 - 0.031 14.7 0.2 0.6 10.6 0.0 2.4 1 1 1 2 2 2 0 Alkyl sulfatase dimerisation XPC-binding PF09280.11 CCF49835.1 - 0.042 13.6 3.3 0.12 12.1 3.3 1.8 1 0 0 1 1 1 0 XPC-binding domain TPR_6 PF13174.6 CCF49835.1 - 0.054 14.2 1.1 44 5.0 0.0 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat STI1 PF17830.1 CCF49835.1 - 0.12 12.3 16.6 0.22 11.5 8.0 2.6 2 0 0 2 2 2 0 STI1 domain MIT PF04212.18 CCF49835.1 - 0.51 10.4 4.7 12 6.0 0.0 3.0 3 1 0 3 3 2 0 MIT (microtubule interacting and transport) domain TPR_3 PF07720.12 CCF49835.1 - 0.94 9.5 0.1 0.94 9.5 0.1 2.4 3 0 0 3 3 2 0 Tetratricopeptide repeat Pkinase PF00069.25 CCF49836.1 - 1.5e-43 149.1 0.0 2.3e-43 148.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF49836.1 - 5.5e-18 65.2 0.0 8.8e-18 64.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.22 CCF49836.1 - 2.7e-05 23.9 0.0 5.3e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 RIO1 family DUF294_C PF10335.9 CCF49836.1 - 0.0077 16.0 0.0 0.026 14.3 0.0 1.9 1 0 0 1 1 1 1 Putative nucleotidyltransferase substrate binding domain APH PF01636.23 CCF49836.1 - 0.017 15.1 0.0 0.017 15.1 0.0 2.3 3 0 0 3 3 3 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 CCF49836.1 - 0.094 11.5 0.0 0.094 11.5 0.0 1.7 2 0 0 2 2 2 0 Fungal protein kinase putAbiC PF16872.5 CCF49836.1 - 0.15 12.8 0.1 0.51 11.1 0.0 1.9 2 0 0 2 2 2 0 Putative phage abortive infection protein Amidase PF01425.21 CCF49837.1 - 2e-100 336.9 0.0 2.8e-100 336.4 0.0 1.2 1 0 0 1 1 1 1 Amidase Cu-oxidase_3 PF07732.15 CCF49838.1 - 3.6e-34 117.3 0.5 1.3e-33 115.5 0.5 2.1 1 0 0 1 1 1 1 Multicopper oxidase Cu-oxidase_2 PF07731.14 CCF49838.1 - 4.1e-30 104.3 1.4 1.1e-24 86.7 0.1 3.4 2 1 0 2 2 2 2 Multicopper oxidase Cu-oxidase PF00394.22 CCF49838.1 - 2.6e-17 63.4 0.0 6.3e-14 52.4 0.0 3.3 2 1 0 2 2 2 2 Multicopper oxidase HMG_CoA_synt_N PF01154.17 CCF49839.1 - 4.6e-86 287.1 0.1 9.3e-86 286.1 0.1 1.5 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase N terminal HMG_CoA_synt_C PF08540.10 CCF49839.1 - 1.3e-82 277.6 0.4 1.7e-82 277.2 0.4 1.1 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase C terminal ACP_syn_III_C PF08541.10 CCF49839.1 - 0.0067 16.6 0.0 0.047 13.9 0.0 2.2 2 0 0 2 2 2 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal ACP_syn_III PF08545.10 CCF49839.1 - 0.13 12.2 0.2 0.57 10.1 0.1 2.1 2 0 0 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III RRM_1 PF00076.22 CCF49840.1 - 1.3e-29 101.8 0.2 8e-15 54.4 0.0 5.2 4 1 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CCF49840.1 - 0.0013 18.8 0.0 0.0077 16.3 0.0 2.2 2 0 0 2 2 2 1 RNA recognition motif RRM_9 PF18444.1 CCF49840.1 - 0.0071 16.2 0.0 0.053 13.4 0.0 2.3 2 0 0 2 2 2 1 RNA recognition motif RRM_occluded PF16842.5 CCF49840.1 - 0.055 13.3 0.0 1.8 8.5 0.0 2.7 3 0 0 3 3 3 0 Occluded RNA-recognition motif DUF1866 PF08952.11 CCF49840.1 - 0.15 11.9 0.0 12 5.7 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1866) FF PF01846.19 CCF49841.1 - 1.7e-22 79.3 4.6 4.7e-11 42.7 0.0 5.6 6 0 0 6 6 6 3 FF domain WW PF00397.26 CCF49841.1 - 4.6e-13 49.0 16.6 1.1e-06 28.7 7.0 2.6 2 0 0 2 2 2 2 WW domain RhoGAP-FF1 PF16512.5 CCF49841.1 - 0.0096 16.6 3.9 0.048 14.3 0.0 3.4 3 0 0 3 3 3 1 p190-A and -B Rho GAPs FF domain IgG_binding_B PF01378.17 CCF49841.1 - 0.054 13.6 0.5 0.16 12.0 0.5 1.8 1 0 0 1 1 1 0 B domain SOG2 PF10428.9 CCF49841.1 - 0.2 10.8 4.2 0.33 10.1 4.2 1.5 1 0 0 1 1 1 0 RAM signalling pathway protein WD40 PF00400.32 CCF49842.1 - 2.1e-13 50.5 1.2 0.2 12.6 0.1 6.4 6 0 0 6 6 6 5 WD domain, G-beta repeat Phe_tRNA-synt_N PF02912.18 CCF49845.1 - 0.02 14.8 1.0 0.03 14.2 0.2 1.6 2 0 0 2 2 2 0 Aminoacyl tRNA synthetase class II, N-terminal domain VPS9 PF02204.18 CCF49846.1 - 1.5e-30 105.4 0.2 2.7e-30 104.7 0.2 1.4 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain DUF5601 PF18151.1 CCF49846.1 - 3.7e-12 46.4 0.1 1.3e-11 44.7 0.1 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF5601) CUE PF02845.16 CCF49846.1 - 8.6e-10 38.1 0.0 2e-09 37.0 0.0 1.7 1 0 0 1 1 1 1 CUE domain DMA PF03474.14 CCF49846.1 - 0.00043 19.8 0.0 0.00079 19.0 0.0 1.4 1 0 0 1 1 1 1 DMRTA motif Ctr PF04145.15 CCF49847.1 - 1.7e-36 126.1 0.7 2.1e-36 125.7 0.7 1.1 1 0 0 1 1 1 1 Ctr copper transporter family Exonuc_VII_L PF02601.15 CCF49848.1 - 0.009 15.6 0.9 0.015 14.9 0.9 1.3 1 0 0 1 1 1 1 Exonuclease VII, large subunit ABC_tran_CTD PF16326.5 CCF49848.1 - 3.3 8.0 8.1 7.8 6.8 1.0 2.7 1 1 1 2 2 2 0 ABC transporter C-terminal domain Zw10 PF06248.13 CCF49849.1 - 7.3e-14 51.2 0.8 4.9e-08 32.0 0.0 2.2 2 0 0 2 2 2 2 Centromere/kinetochore Zw10 Dor1 PF04124.12 CCF49849.1 - 0.015 14.0 1.4 0.037 12.7 1.4 1.6 1 0 0 1 1 1 0 Dor1-like family Dynactin_p22 PF07426.11 CCF49849.1 - 0.056 13.3 1.3 0.12 12.2 1.3 1.6 1 0 0 1 1 1 0 Dynactin subunit p22 Cellulase PF00150.18 CCF49850.1 - 2.8e-08 33.5 0.1 5.3e-08 32.6 0.1 1.4 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) DUF1752 PF08550.10 CCF49851.1 - 1.2e-12 47.4 3.2 2.9e-12 46.2 3.2 1.7 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) TrbM PF07424.11 CCF49851.1 - 0.022 14.7 0.1 0.047 13.6 0.1 1.4 1 0 0 1 1 1 0 TrbM DUF1387 PF07139.11 CCF49852.1 - 0.07 12.9 23.2 0.017 14.9 6.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1387) DNase_NucA_NucB PF14040.6 CCF49852.1 - 0.69 10.3 8.0 0.56 10.6 1.7 2.9 2 0 0 2 2 2 0 Deoxyribonuclease NucA/NucB Dysbindin PF04440.16 CCF49852.1 - 2.6 8.2 14.4 0.25 11.5 7.1 2.8 2 1 0 2 2 2 0 Dysbindin (Dystrobrevin binding protein 1) Flavodoxin_1 PF00258.25 CCF49853.1 - 8.6e-31 107.1 0.0 1.8e-30 106.0 0.0 1.6 2 0 0 2 2 2 1 Flavodoxin FAD_binding_1 PF00667.20 CCF49853.1 - 2.1e-23 83.1 0.0 6.7e-23 81.4 0.0 1.8 1 1 0 1 1 1 1 FAD binding domain NAD_binding_1 PF00175.21 CCF49853.1 - 1.1e-09 38.9 0.0 2e-09 38.0 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Sds3 PF08598.11 CCF49854.1 - 2.9e-36 125.5 1.8 6.6e-36 124.4 1.8 1.6 1 0 0 1 1 1 1 Sds3-like Dynamin_M PF01031.20 CCF49855.1 - 1.1e-109 366.0 0.0 1.9e-109 365.3 0.0 1.3 1 0 0 1 1 1 1 Dynamin central region Dynamin_N PF00350.23 CCF49855.1 - 5.7e-56 189.2 0.0 1.5e-55 187.8 0.0 1.7 1 1 0 1 1 1 1 Dynamin family GED PF02212.18 CCF49855.1 - 2.5e-29 101.3 1.5 3.8e-29 100.7 0.5 1.9 2 0 0 2 2 2 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.23 CCF49855.1 - 4.7e-05 23.4 0.1 0.0018 18.3 0.0 2.8 2 1 0 2 2 2 1 50S ribosome-binding GTPase AIG1 PF04548.16 CCF49855.1 - 0.054 12.8 0.1 3.9 6.7 0.0 2.5 2 0 0 2 2 2 0 AIG1 family TipAS PF07739.13 CCF49855.1 - 0.093 13.3 0.1 0.29 11.7 0.0 1.8 2 0 0 2 2 2 0 TipAS antibiotic-recognition domain ATP-synt_ab PF00006.25 CCF49856.1 - 6.6e-72 241.6 0.0 9.4e-72 241.1 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.27 CCF49856.1 - 5e-38 130.3 0.0 8.5e-38 129.5 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.23 CCF49856.1 - 8.1e-20 71.1 1.9 1.9e-19 69.9 1.9 1.7 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain HAS-barrel PF09378.10 CCF49856.1 - 0.056 13.6 0.4 0.17 12.0 0.4 1.9 1 1 0 1 1 1 0 HAS barrel domain Ribosomal_L21p PF00829.21 CCF49857.1 - 9.1e-22 77.2 1.4 9.8e-12 45.0 1.4 2.2 2 0 0 2 2 2 2 Ribosomal prokaryotic L21 protein Vezatin PF12632.7 CCF49858.1 - 6.4e-16 58.6 7.5 7.3e-14 51.8 0.5 4.2 4 0 0 4 4 4 2 Mysoin-binding motif of peroxisomes Trypan_PARP PF05887.11 CCF49858.1 - 0.19 11.7 5.8 0.51 10.3 5.8 1.6 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) DUF3405 PF11885.8 CCF49859.1 - 3.3e-82 276.8 6.0 9.7e-53 179.5 0.5 3.3 1 1 2 3 3 3 3 Protein of unknown function (DUF3405) Tli4_N PF18443.1 CCF49859.1 - 0.15 12.5 0.0 0.3 11.4 0.0 1.4 1 0 0 1 1 1 0 Tle cognate immunity protein 4 N-terminal domain START PF01852.19 CCF49860.1 - 1.4e-19 70.4 0.3 9.8e-09 34.9 0.1 4.1 4 0 0 4 4 4 3 START domain Hap4_Hap_bind PF10297.9 CCF49860.1 - 0.66 10.2 3.4 2.5 8.3 3.4 2.1 1 0 0 1 1 1 0 Minimal binding motif of Hap4 for binding to Hap2/3/5 G-alpha PF00503.20 CCF49861.1 - 8.5e-82 275.1 0.0 1.3e-81 274.6 0.0 1.2 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 CCF49861.1 - 3.9e-12 46.0 0.0 8.7e-08 31.8 0.0 2.5 2 0 0 2 2 2 2 ADP-ribosylation factor family AAA_22 PF13401.6 CCF49861.1 - 4e-05 23.9 0.0 0.00011 22.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 CCF49861.1 - 0.0022 17.7 0.2 0.0082 15.9 0.0 1.9 1 1 1 2 2 2 1 AAA domain ABC_tran PF00005.27 CCF49861.1 - 0.0068 16.9 0.1 0.018 15.5 0.0 1.9 2 0 0 2 2 2 1 ABC transporter AAA_24 PF13479.6 CCF49861.1 - 0.0072 16.1 0.0 0.023 14.4 0.0 1.8 2 0 0 2 2 2 1 AAA domain Roc PF08477.13 CCF49861.1 - 0.016 15.5 0.0 0.89 9.8 0.0 2.5 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase RsgA_GTPase PF03193.16 CCF49861.1 - 0.063 13.2 0.0 1.7 8.5 0.0 2.3 2 0 0 2 2 2 0 RsgA GTPase Gtr1_RagA PF04670.12 CCF49861.1 - 0.077 12.3 0.0 2.9 7.2 0.0 2.2 2 0 0 2 2 2 0 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 CCF49861.1 - 0.079 12.5 0.0 4.7 6.7 0.0 2.4 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain AAA_16 PF13191.6 CCF49861.1 - 0.11 12.8 0.3 0.7 10.3 0.0 2.3 2 0 0 2 2 2 0 AAA ATPase domain TniB PF05621.11 CCF49861.1 - 0.18 11.2 0.0 0.36 10.2 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein Ribosomal_L28e PF01778.17 CCF49863.1 - 1.6e-38 132.0 1.3 1.6e-38 132.0 1.3 2.1 2 0 0 2 2 2 1 Ribosomal L28e protein family Mak16 PF04874.14 CCF49863.1 - 2.1e-27 95.6 14.3 2.1e-27 95.6 14.3 2.6 2 0 0 2 2 2 1 Mak16 protein C-terminal region BUD22 PF09073.10 CCF49863.1 - 0.00025 20.5 21.6 0.00036 20.0 21.6 1.2 1 0 0 1 1 1 1 BUD22 PYC_OADA PF02436.18 CCF49863.1 - 0.014 15.1 2.6 0.028 14.1 2.6 1.7 1 1 0 1 1 1 0 Conserved carboxylase domain FNIP_N PF14636.6 CCF49863.1 - 0.21 12.6 4.4 0.34 11.9 0.3 2.2 2 0 0 2 2 2 0 Folliculin-interacting protein N-terminus TFIIA PF03153.13 CCF49864.1 - 0.0044 17.1 35.7 0.0044 17.1 35.7 3.4 3 1 0 3 3 2 1 Transcription factor IIA, alpha/beta subunit DDHD PF02862.17 CCF49864.1 - 0.049 13.8 19.1 0.086 13.0 2.0 2.5 2 0 0 2 2 2 0 DDHD domain EPL1 PF10513.9 CCF49864.1 - 0.069 13.5 21.5 0.052 13.9 1.2 2.8 2 0 0 2 2 2 0 Enhancer of polycomb-like LAP1C PF05609.12 CCF49864.1 - 0.35 9.9 29.5 0.029 13.5 4.8 2.2 2 0 0 2 2 2 0 Lamina-associated polypeptide 1C (LAP1C) Utp14 PF04615.13 CCF49864.1 - 0.36 9.4 34.3 0.028 13.0 11.2 2.1 2 0 0 2 2 2 0 Utp14 protein BAF1_ABF1 PF04684.13 CCF49864.1 - 0.5 9.4 28.6 0.01 15.0 8.1 2.3 2 0 0 2 2 2 0 BAF1 / ABF1 chromatin reorganising factor Velvet PF11754.8 CCF49864.1 - 0.59 10.0 30.3 1.3 8.9 12.3 2.8 2 0 0 2 2 2 0 Velvet factor Endostatin PF06482.11 CCF49864.1 - 1.4 8.3 18.5 1.5 8.3 0.3 2.3 2 0 0 2 2 2 0 Collagenase NC10 and Endostatin FAM60A PF15396.6 CCF49864.1 - 2.1 8.3 17.8 1.1 9.2 1.7 2.5 2 0 0 2 2 2 0 Protein Family FAM60A CENP-B_dimeris PF09026.10 CCF49864.1 - 2.7 8.4 16.9 0.28 11.6 9.8 2.5 2 0 0 2 2 2 0 Centromere protein B dimerisation domain PPP4R2 PF09184.11 CCF49864.1 - 3.3 7.2 37.6 0.21 11.2 22.2 2.4 2 0 0 2 2 2 0 PPP4R2 CNDH2_C PF16858.5 CCF49864.1 - 7.1 6.4 22.5 6 6.7 4.8 2.3 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term Tim17 PF02466.19 CCF49865.1 - 2.3e-09 37.6 0.4 2.3e-09 37.6 0.4 1.5 2 0 0 2 2 2 1 Tim17/Tim22/Tim23/Pmp24 family GPI-anchored PF10342.9 CCF49866.1 - 0.071 13.9 0.1 0.18 12.6 0.1 1.7 1 0 0 1 1 1 0 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family RRM_1 PF00076.22 CCF49867.1 - 1.7e-06 27.7 0.4 0.031 14.1 0.0 3.0 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_Rrp7 PF17799.1 CCF49867.1 - 0.0035 17.2 0.4 0.015 15.1 0.2 2.1 2 0 0 2 2 2 1 Rrp7 RRM-like N-terminal domain FAM92 PF06730.11 CCF49867.1 - 0.073 12.5 0.1 0.073 12.5 0.1 2.1 2 0 0 2 2 2 0 FAM92 protein MFS_1 PF07690.16 CCF49868.1 - 3.1e-34 118.4 37.2 7.4e-34 117.2 29.3 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Polyketide_cyc PF03364.20 CCF49869.1 - 3.6e-26 91.9 0.0 6.7e-26 91.0 0.0 1.5 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Epimerase PF01370.21 CCF49869.1 - 4.3e-06 26.4 0.0 1.5e-05 24.6 0.0 2.0 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polyketide_cyc2 PF10604.9 CCF49869.1 - 2e-05 24.9 0.0 4.3e-05 23.8 0.0 1.6 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport adh_short PF00106.25 CCF49869.1 - 0.016 14.7 0.0 0.029 13.8 0.0 1.4 1 0 0 1 1 1 0 short chain dehydrogenase GDP_Man_Dehyd PF16363.5 CCF49869.1 - 0.023 14.1 0.0 0.038 13.4 0.0 1.3 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase KR PF08659.10 CCF49869.1 - 0.03 14.2 0.0 0.17 11.8 0.0 2.1 2 0 0 2 2 2 0 KR domain MFS_1 PF07690.16 CCF49870.1 - 5.7e-32 111.0 37.4 2e-26 92.7 21.5 1.6 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF49870.1 - 8.5e-26 90.8 15.6 7.9e-18 64.6 5.3 2.2 1 1 1 2 2 2 2 Sugar (and other) transporter DUF1980 PF09323.10 CCF49871.1 - 0.16 11.9 0.8 0.32 10.9 0.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) KRTAP PF11759.8 CCF49871.1 - 0.26 11.8 4.5 7.1 7.3 0.6 2.6 2 0 0 2 2 2 0 Keratin-associated matrix RCC1_2 PF13540.6 CCF49872.1 - 1.2e-14 53.6 10.8 0.00025 20.8 0.0 6.2 6 0 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 CCF49872.1 - 1.6e-11 44.6 0.3 0.97 10.1 0.0 6.1 6 0 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat F-box PF00646.33 CCF49872.1 - 5.8e-06 26.1 0.5 5.8e-06 26.1 0.5 1.9 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.7 CCF49872.1 - 3.7e-05 23.5 0.2 0.00012 21.9 0.3 1.9 2 0 0 2 2 2 1 F-box-like TFIIA PF03153.13 CCF49872.1 - 0.33 10.9 12.7 0.017 15.2 3.6 2.2 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit RXT2_N PF08595.11 CCF49872.1 - 0.67 10.0 7.3 3 7.8 7.2 2.0 2 0 0 2 2 2 0 RXT2-like, N-terminal PPP4R2 PF09184.11 CCF49872.1 - 0.95 9.0 10.8 0.015 14.9 3.7 1.5 2 0 0 2 2 2 0 PPP4R2 NOA36 PF06524.12 CCF49872.1 - 1.1 8.5 15.5 2.1 7.6 15.5 1.4 1 0 0 1 1 1 0 NOA36 protein Fungal_trans PF04082.18 CCF49873.1 - 8.6e-08 31.5 0.5 8.6e-08 31.5 0.5 2.0 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF49873.1 - 6.9e-05 22.9 6.7 0.00014 21.9 6.7 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Dickkopf_N PF04706.12 CCF49873.1 - 8.1 7.0 8.2 14 6.2 0.2 2.6 2 0 0 2 2 2 0 Dickkopf N-terminal cysteine-rich region WD40 PF00400.32 CCF49874.1 - 1.4e-22 79.5 4.0 0.0006 20.6 0.0 7.1 6 0 0 6 6 6 6 WD domain, G-beta repeat PFU PF09070.11 CCF49874.1 - 1.5e-14 54.2 0.0 2.9e-14 53.3 0.0 1.4 1 0 0 1 1 1 1 PFU (PLAA family ubiquitin binding) PCNA_N PF00705.18 CCF49875.1 - 4.1e-48 162.3 1.0 1e-47 161.0 1.0 1.6 1 0 0 1 1 1 1 Proliferating cell nuclear antigen, N-terminal domain PCNA_C PF02747.15 CCF49875.1 - 1.8e-43 147.8 0.9 6.6e-22 78.0 0.2 2.6 3 0 0 3 3 3 2 Proliferating cell nuclear antigen, C-terminal domain Rad9 PF04139.13 CCF49875.1 - 9.2e-05 22.0 0.0 0.00074 19.0 0.0 2.2 2 1 1 3 3 3 1 Rad9 Bac_A_amyl_C PF18612.1 CCF49875.1 - 0.094 12.5 0.0 0.26 11.1 0.0 1.8 1 0 0 1 1 1 0 Bacterial Alpha amylase C-terminal domain Sec34 PF04136.15 CCF49876.1 - 2.5e-34 118.3 0.6 5.3e-34 117.2 0.6 1.6 1 0 0 1 1 1 1 Sec34-like family DUF632 PF04782.12 CCF49876.1 - 0.016 14.5 0.1 0.13 11.6 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF632) TolA_bind_tri PF16331.5 CCF49876.1 - 5.8 7.1 6.2 4.4 7.5 1.6 2.9 2 1 1 3 3 3 0 TolA binding protein trimerisation Actin PF00022.19 CCF49877.1 - 3.3e-111 371.8 0.0 1.5e-110 369.6 0.0 1.7 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 CCF49877.1 - 0.021 13.7 0.0 0.074 11.9 0.0 1.8 1 1 0 1 1 1 0 MreB/Mbl protein PX PF00787.24 CCF49878.1 - 1.3e-13 50.9 0.0 3.7e-13 49.4 0.0 1.7 2 0 0 2 2 2 1 PX domain Macoilin PF09726.9 CCF49878.1 - 0.016 13.8 0.3 0.02 13.5 0.3 1.1 1 0 0 1 1 1 0 Macoilin family Stm1_N PF09598.10 CCF49878.1 - 0.072 13.9 0.6 0.072 13.9 0.6 2.9 2 1 0 2 2 2 0 Stm1 NPV_P10 PF05531.12 CCF49878.1 - 2.7 8.5 5.3 17 6.0 4.3 2.2 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein Aldedh PF00171.22 CCF49879.1 - 7.4e-157 522.5 0.0 9.5e-157 522.2 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.14 CCF49879.1 - 0.028 13.5 0.0 0.043 12.9 0.0 1.2 1 0 0 1 1 1 0 Acyl-CoA reductase (LuxC) DUF1487 PF07368.11 CCF49879.1 - 0.076 12.4 0.0 0.14 11.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1487) UCH PF00443.29 CCF49880.1 - 1.1e-61 208.6 0.0 1.9e-61 207.8 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 CCF49880.1 - 6.1e-17 62.2 0.0 2.6e-15 56.9 0.0 2.2 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase USP8_dimer PF08969.11 CCF49880.1 - 4.2e-07 30.1 0.4 1e-06 28.9 0.4 1.6 1 0 0 1 1 1 1 USP8 dimerisation domain Rhodanese PF00581.20 CCF49880.1 - 0.0043 17.6 0.0 0.013 16.0 0.0 1.8 1 1 0 1 1 1 1 Rhodanese-like domain zf-MIZ PF02891.20 CCF49880.1 - 0.0083 15.9 0.1 0.018 14.8 0.1 1.5 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger DivIVA PF05103.13 CCF49880.1 - 0.16 12.0 3.4 6.6 6.8 0.0 2.5 2 0 0 2 2 2 0 DivIVA protein Plus-3 PF03126.18 CCF49881.1 - 1.6e-17 64.0 0.0 4e-17 62.7 0.0 1.8 1 0 0 1 1 1 1 Plus-3 domain Med3 PF11593.8 CCF49881.1 - 0.093 11.9 5.0 0.18 10.9 5.0 1.4 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal V_ATPase_I PF01496.19 CCF49881.1 - 2.1 6.2 5.7 0.15 9.9 0.4 1.6 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family TPR_1 PF00515.28 CCF49883.1 - 1.4e-35 119.6 9.6 1.4e-05 24.7 0.2 8.1 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_2 PF07719.17 CCF49883.1 - 3.8e-33 110.9 12.8 0.00049 20.0 0.1 8.8 8 0 0 8 8 8 7 Tetratricopeptide repeat TPR_19 PF14559.6 CCF49883.1 - 1.7e-22 79.7 21.6 1.9e-08 34.7 3.1 5.8 4 2 2 6 6 6 6 Tetratricopeptide repeat DnaJ PF00226.31 CCF49883.1 - 1.2e-21 76.6 2.6 2.6e-21 75.5 2.6 1.6 1 0 0 1 1 1 1 DnaJ domain TPR_14 PF13428.6 CCF49883.1 - 2.5e-19 68.3 16.0 9.2e-05 23.0 0.8 8.2 5 3 4 9 9 7 4 Tetratricopeptide repeat TPR_16 PF13432.6 CCF49883.1 - 7.5e-19 68.1 24.0 1.9e-09 38.0 2.9 5.9 5 1 1 6 6 6 3 Tetratricopeptide repeat TPR_12 PF13424.6 CCF49883.1 - 5.1e-18 65.1 20.1 7.9e-05 22.9 2.9 6.9 6 2 0 6 6 6 4 Tetratricopeptide repeat TPR_11 PF13414.6 CCF49883.1 - 2.4e-13 49.5 12.3 6e-05 22.6 0.0 6.9 5 3 2 7 7 6 4 TPR repeat TPR_8 PF13181.6 CCF49883.1 - 4e-13 48.4 14.8 0.031 14.5 0.0 8.1 9 0 0 9 9 8 3 Tetratricopeptide repeat TPR_17 PF13431.6 CCF49883.1 - 4.1e-11 42.5 10.4 0.0022 18.3 0.1 6.7 7 0 0 7 7 6 4 Tetratricopeptide repeat ANAPC3 PF12895.7 CCF49883.1 - 2e-09 37.5 11.3 0.028 14.6 0.2 5.2 3 1 2 5 5 5 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 CCF49883.1 - 2.9e-09 36.3 12.4 0.17 12.0 0.0 7.7 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_9 PF13371.6 CCF49883.1 - 1.4e-08 34.8 18.7 8e-06 25.9 1.5 5.2 4 2 2 6 6 6 2 Tetratricopeptide repeat TPR_MalT PF17874.1 CCF49883.1 - 1e-05 25.1 21.1 0.34 10.2 0.0 5.2 1 1 2 5 5 5 2 MalT-like TPR region TPR_6 PF13174.6 CCF49883.1 - 3.1e-05 24.3 13.7 8.1 7.3 0.1 7.2 8 0 0 8 8 6 0 Tetratricopeptide repeat Coatomer_E PF04733.14 CCF49883.1 - 0.013 14.9 3.7 0.23 10.9 0.1 3.3 3 1 1 4 4 4 0 Coatomer epsilon subunit Integrin_beta PF00362.18 CCF49883.1 - 0.052 13.2 0.5 0.13 11.9 0.5 1.6 1 1 0 1 1 1 0 Integrin beta chain VWA domain SHNi-TPR PF10516.9 CCF49883.1 - 0.084 12.3 0.2 0.084 12.3 0.2 3.3 4 0 0 4 4 4 0 SHNi-TPR DUF3856 PF12968.7 CCF49883.1 - 0.22 11.6 7.7 0.24 11.5 2.1 3.2 2 1 0 2 2 2 0 Domain of Unknown Function (DUF3856) TPR_4 PF07721.14 CCF49883.1 - 0.84 10.4 20.1 0.16 12.7 0.7 6.5 6 1 0 6 6 6 0 Tetratricopeptide repeat DUF627 PF04781.12 CCF49883.1 - 0.93 9.5 17.2 7.8 6.6 3.0 5.3 4 2 0 4 4 4 0 Protein of unknown function (DUF627) BTAD PF03704.17 CCF49883.1 - 1.2 9.6 18.8 36 4.8 8.3 4.8 2 1 1 3 3 3 0 Bacterial transcriptional activator domain TPR_10 PF13374.6 CCF49883.1 - 2.5 8.1 18.9 7.1 6.7 0.8 5.8 6 0 0 6 6 6 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 CCF49883.1 - 3.4 7.8 12.4 15 5.8 0.0 5.6 7 1 0 8 8 7 0 Fis1 C-terminal tetratricopeptide repeat TPR_20 PF14561.6 CCF49883.1 - 7.3 7.0 18.2 0.69 10.3 1.2 4.4 3 1 1 4 4 4 0 Tetratricopeptide repeat DUF3947 PF13135.6 CCF49883.1 - 9.9 6.4 10.2 1.2 9.3 0.1 3.3 2 1 1 3 3 3 0 Protein of unknown function (DUF3947) PseudoU_synth_1 PF01416.20 CCF49884.1 - 3.2e-11 43.6 0.0 1.1e-09 38.8 0.0 2.7 3 0 0 3 3 3 1 tRNA pseudouridine synthase Herpes_VP19C PF03327.14 CCF49884.1 - 0.078 12.4 0.0 11 5.4 0.0 2.3 2 0 0 2 2 2 0 Herpesvirus capsid shell protein VP19C Phage_stabilise PF11134.8 CCF49884.1 - 0.12 11.2 0.0 0.18 10.7 0.0 1.1 1 0 0 1 1 1 0 Phage stabilisation protein SR-25 PF10500.9 CCF49884.1 - 0.3 10.6 20.8 0.017 14.8 8.2 2.4 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Chorion_2 PF03964.15 CCF49884.1 - 2.8 8.8 8.8 0.67 10.8 1.8 2.6 2 0 0 2 2 2 0 Chorion family 2 PAP1 PF08601.10 CCF49884.1 - 7 6.3 10.1 0.28 10.9 1.0 2.1 2 0 0 2 2 2 0 Transcription factor PAP1 WD40 PF00400.32 CCF49885.1 - 3.1e-32 110.1 34.0 1e-06 29.4 0.5 8.8 8 0 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF49885.1 - 4.9e-14 52.4 2.4 0.028 14.7 0.0 6.7 2 1 3 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 CCF49885.1 - 1.8e-10 40.7 0.0 0.0012 18.2 0.0 3.0 2 1 1 3 3 3 2 WD40-like domain F-box-like PF12937.7 CCF49885.1 - 8.5e-10 38.4 0.7 2.1e-09 37.1 0.7 1.7 1 0 0 1 1 1 1 F-box-like Nup160 PF11715.8 CCF49885.1 - 9.4e-09 34.4 3.7 0.19 10.3 0.0 5.6 4 1 1 5 5 5 4 Nucleoporin Nup120/160 F-box PF00646.33 CCF49885.1 - 0.0008 19.2 1.7 0.0017 18.2 1.7 1.6 1 0 0 1 1 1 1 F-box domain DUF5046 PF16465.5 CCF49885.1 - 0.0026 17.2 0.0 0.19 11.2 0.0 2.5 1 1 1 2 2 2 1 Domain of unknown function (DUF5046) DNA_pol3_gamma3 PF12169.8 CCF49885.1 - 0.16 11.9 0.3 0.34 10.8 0.3 1.5 1 0 0 1 1 1 0 DNA polymerase III subunits gamma and tau domain III Nramp PF01566.18 CCF49887.1 - 9.6e-88 294.5 14.2 2.5e-49 168.2 2.9 2.2 2 0 0 2 2 2 2 Natural resistance-associated macrophage protein NAD_binding_4 PF07993.12 CCF49888.1 - 1.1e-27 96.8 0.0 1.6e-27 96.3 0.0 1.2 1 0 0 1 1 1 1 Male sterility protein Epimerase PF01370.21 CCF49888.1 - 0.00028 20.4 0.0 0.00045 19.8 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CCF49888.1 - 0.056 12.8 0.0 0.078 12.4 0.0 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Amino_oxidase PF01593.24 CCF49889.1 - 2.8e-10 40.1 0.0 3e-10 40.0 0.0 1.0 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase Ribosomal_L24e PF01246.20 CCF49891.1 - 1.6e-30 105.1 6.9 2.9e-30 104.3 6.9 1.4 1 0 0 1 1 1 1 Ribosomal protein L24e HAGH_C PF16123.5 CCF49891.1 - 0.0041 17.6 1.3 0.0099 16.4 1.3 1.6 1 0 0 1 1 1 1 Hydroxyacylglutathione hydrolase C-terminus zf-CCCH PF00642.24 CCF49892.1 - 3.8e-17 61.7 35.2 9.2e-05 22.3 1.2 5.7 4 1 1 5 5 5 5 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 CCF49892.1 - 3.6e-13 49.1 35.8 4.1e-06 26.7 3.1 5.7 5 0 0 5 5 5 4 Zinc finger domain Torus PF16131.5 CCF49892.1 - 2.8e-09 37.6 22.0 2.9e-05 24.7 0.3 5.1 1 1 4 5 5 5 3 Torus domain zf-CCHC PF00098.23 CCF49892.1 - 1.1e-06 28.4 1.0 6.4e-06 26.0 1.0 2.5 1 0 0 1 1 1 1 Zinc knuckle zf-CCCH_4 PF18044.1 CCF49892.1 - 2.1e-05 24.2 0.6 2.1e-05 24.2 0.6 5.2 5 0 0 5 5 5 1 CCCH-type zinc finger zf-CCCH_3 PF15663.5 CCF49892.1 - 0.058 13.6 17.4 3.3 8.0 5.2 4.0 2 1 2 4 4 4 0 Zinc-finger containing family gag_pre-integrs PF13976.6 CCF49893.1 - 1.6e-05 24.7 1.7 4.1e-05 23.3 1.7 1.8 1 1 0 1 1 1 1 GAG-pre-integrase domain rve PF00665.26 CCF49893.1 - 0.022 15.0 0.1 0.051 13.8 0.1 1.6 1 0 0 1 1 1 0 Integrase core domain Zn_clus PF00172.18 CCF49895.1 - 0.0015 18.6 5.8 0.0029 17.7 5.8 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF2515 PF10720.9 CCF49895.1 - 0.039 13.1 0.1 0.088 12.0 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2515) WD40 PF00400.32 CCF49896.1 - 7.9e-39 131.0 12.5 2.3e-06 28.2 0.0 8.1 7 1 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF49896.1 - 1.3e-15 57.5 0.1 0.0063 16.8 0.0 5.8 4 1 2 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain PRP4 PF08799.11 CCF49896.1 - 2.7e-10 39.6 5.8 6.9e-10 38.3 5.8 1.7 1 0 0 1 1 1 1 pre-mRNA processing factor 4 (PRP4) like Ge1_WD40 PF16529.5 CCF49896.1 - 5.3e-08 32.2 0.4 1.1 8.1 0.0 4.3 2 1 1 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 CCF49896.1 - 1.6e-05 23.7 5.5 0.15 10.7 0.1 4.1 1 1 4 5 5 5 2 Nucleoporin Nup120/160 WD40_like PF17005.5 CCF49896.1 - 2e-05 24.1 0.0 0.015 14.6 0.0 2.4 2 1 0 2 2 2 2 WD40-like domain Nbas_N PF15492.6 CCF49896.1 - 0.00017 21.0 1.1 0.026 13.8 0.0 3.4 3 1 0 4 4 4 1 Neuroblastoma-amplified sequence, N terminal eIF2A PF08662.11 CCF49896.1 - 0.00032 20.6 0.0 1 9.2 0.0 3.8 2 1 2 4 4 4 2 Eukaryotic translation initiation factor eIF2A Methyltransf_24 PF13578.6 CCF49896.1 - 0.042 14.9 0.2 7.1 7.7 0.0 2.8 2 0 0 2 2 2 0 Methyltransferase domain UPF0669 PF17065.5 CCF49896.1 - 0.067 13.0 0.2 0.11 12.2 0.2 1.3 1 0 0 1 1 1 0 Putative cytokine, C6ORF120 HPS3_N PF14761.6 CCF49896.1 - 0.081 12.4 0.0 0.29 10.7 0.1 1.8 2 0 0 2 2 2 0 Hermansky-Pudlak syndrome 3 PRAS PF15798.5 CCF49896.1 - 0.092 13.3 1.4 0.25 11.9 0.8 2.1 2 0 0 2 2 1 0 Proline-rich AKT1 substrate 1 ANAPC_CDC26 PF10471.9 CCF49896.1 - 0.85 10.5 13.1 0.097 13.5 2.5 2.6 2 0 0 2 2 2 0 Anaphase-promoting complex APC subunit CDC26 DUF4611 PF15387.6 CCF49896.1 - 0.86 9.9 5.5 0.34 11.1 0.5 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) SUIM_assoc PF16619.5 CCF49896.1 - 1.1 9.4 11.7 3.6 7.7 11.7 1.8 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 Spt20 PF12090.8 CCF49896.1 - 4.9 6.7 12.1 0.069 12.8 4.7 1.6 2 0 0 2 2 1 0 Spt20 family PMT PF02366.18 CCF49897.1 - 6.3e-83 278.1 14.6 1.3e-82 277.1 14.6 1.5 1 0 0 1 1 1 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 CCF49897.1 - 1.2e-65 220.8 5.0 1.2e-65 220.8 5.0 3.2 2 1 2 4 4 4 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 CCF49897.1 - 1e-20 74.4 0.9 1.6e-20 73.7 0.9 1.2 1 0 0 1 1 1 1 MIR domain PMT_2 PF13231.6 CCF49897.1 - 5.9e-06 26.6 12.1 5.9e-06 26.6 12.1 2.5 3 1 0 3 3 3 1 Dolichyl-phosphate-mannose-protein mannosyltransferase SBDS_C PF09377.10 CCF49898.1 - 3.5e-38 130.2 1.2 6.5e-38 129.3 1.2 1.4 1 0 0 1 1 1 1 SBDS protein C-terminal domain SBDS PF01172.18 CCF49898.1 - 1e-32 112.0 0.4 2.5e-32 110.8 0.2 1.7 2 0 0 2 2 2 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein SLS PF14611.6 CCF49898.1 - 0.0021 17.9 0.9 0.16 11.7 0.2 2.1 2 0 0 2 2 2 2 Mitochondrial inner-membrane-bound regulator Capsid_N PF16903.5 CCF49898.1 - 0.013 15.1 0.0 0.023 14.3 0.0 1.4 1 0 0 1 1 1 0 Major capsid protein N-terminus Noc2 PF03715.13 CCF49899.1 - 5.6e-106 354.2 0.8 9.6e-106 353.4 0.8 1.4 1 0 0 1 1 1 1 Noc2p family XhlA PF10779.9 CCF49899.1 - 0.057 13.6 0.4 0.3 11.3 0.4 2.3 1 0 0 1 1 1 0 Haemolysin XhlA ATPase PF06745.13 CCF49900.1 - 0.0011 18.4 0.0 0.002 17.5 0.0 1.4 1 0 0 1 1 1 1 KaiC SnoaL_2 PF12680.7 CCF49900.1 - 0.15 12.7 0.0 0.4 11.3 0.0 1.7 1 0 0 1 1 1 0 SnoaL-like domain Polysacc_deac_1 PF01522.21 CCF49901.1 - 7.2e-06 25.9 0.0 1.3e-05 25.1 0.0 1.5 1 0 0 1 1 1 1 Polysaccharide deacetylase Mfa1 PF17445.2 CCF49902.1 - 1.7e-31 108.0 3.7 1.8e-31 107.9 3.7 1.0 1 0 0 1 1 1 1 Mating factor A1 DUF4586 PF15239.6 CCF49902.1 - 0.074 13.2 0.0 0.078 13.1 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4586) STE3 PF02076.15 CCF49904.1 - 5.1e-83 278.6 18.2 6.1e-83 278.4 18.2 1.1 1 0 0 1 1 1 1 Pheromone A receptor UPF0139 PF03669.13 CCF49905.1 - 6.7e-05 22.7 0.0 0.00011 22.0 0.0 1.3 1 1 0 1 1 1 1 Uncharacterised protein family (UPF0139) YhhN PF07947.14 CCF49905.1 - 0.021 14.4 0.1 0.024 14.2 0.1 1.1 1 0 0 1 1 1 0 YhhN family Pantoate_ligase PF02569.15 CCF49906.1 - 2.6e-88 295.7 0.0 3.2e-88 295.4 0.0 1.1 1 0 0 1 1 1 1 Pantoate-beta-alanine ligase MotA_activ PF09114.10 CCF49906.1 - 0.18 11.9 0.0 0.38 10.9 0.0 1.5 1 0 0 1 1 1 0 Transcription factor MotA, activation domain CBP4 PF07960.11 CCF49907.1 - 3.9e-06 26.7 0.1 4.4e-06 26.6 0.1 1.0 1 0 0 1 1 1 1 CBP4 DAHP_synth_1 PF00793.20 CCF49908.1 - 4e-97 324.4 0.0 5e-97 324.1 0.0 1.0 1 0 0 1 1 1 1 DAHP synthetase I family Ribosomal_S19 PF00203.21 CCF49909.1 - 3.9e-28 97.2 0.0 4.8e-28 96.9 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S19 OPT PF03169.15 CCF49910.1 - 1.5e-152 509.4 39.8 1.8e-152 509.2 39.8 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein RVT_1 PF00078.27 CCF49913.1 - 2.2e-31 109.1 0.0 4.3e-31 108.1 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 CCF49913.1 - 2.5e-28 98.1 0.0 6.1e-28 96.8 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 CCF49913.1 - 7.8e-19 67.9 0.0 1.6e-18 66.9 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 CCF49913.1 - 1.6e-14 54.1 0.0 3.6e-14 53.0 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Chromo PF00385.24 CCF49913.1 - 1.4e-11 44.1 1.1 3.2e-11 43.0 0.2 2.2 2 0 0 2 2 2 1 Chromo (CHRromatin Organisation MOdifier) domain Retrotrans_gag PF03732.17 CCF49914.1 - 0.00057 20.1 0.1 0.0011 19.2 0.1 1.5 1 0 0 1 1 1 1 Retrotransposon gag protein Iso_dh PF00180.20 CCF49916.1 - 6.3e-09 35.4 0.1 1.8e-08 33.9 0.0 1.6 1 1 1 2 2 2 2 Isocitrate/isopropylmalate dehydrogenase Ten1_2 PF15490.6 CCF49916.1 - 0.033 13.9 0.0 0.093 12.5 0.0 1.7 2 0 0 2 2 2 0 Telomere-capping, CST complex subunit Vps35 PF03635.17 CCF49918.1 - 0 1027.1 0.0 0 1026.4 0.0 1.3 1 1 0 1 1 1 1 Vacuolar protein sorting-associated protein 35 zf-CCHC PF00098.23 CCF49919.1 - 2.3e-06 27.4 1.3 6.3e-06 26.0 1.3 1.8 1 0 0 1 1 1 1 Zinc knuckle RVT_2 PF07727.14 CCF49920.1 - 4.7e-49 167.2 0.7 2.9e-36 125.3 0.0 2.2 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 CCF49920.1 - 1e-09 38.6 0.1 2.1e-09 37.6 0.1 1.5 1 0 0 1 1 1 1 Integrase core domain zf-CCHC PF00098.23 CCF49921.1 - 7.2e-06 25.8 3.2 1.8e-05 24.6 3.2 1.7 1 0 0 1 1 1 1 Zinc knuckle gag_pre-integrs PF13976.6 CCF49921.1 - 0.0036 17.1 0.1 0.014 15.3 0.1 2.1 1 0 0 1 1 1 1 GAG-pre-integrase domain RVT_1 PF00078.27 CCF49922.1 - 3e-31 108.7 0.0 5.8e-31 107.7 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 CCF49922.1 - 2.5e-28 98.0 0.0 7.4e-28 96.5 0.0 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 CCF49922.1 - 6e-19 68.3 0.0 2.2e-18 66.4 0.0 2.0 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 CCF49922.1 - 3.5e-15 56.3 0.0 8.9e-15 54.9 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain Chromo PF00385.24 CCF49922.1 - 1.6e-11 43.9 0.2 5.2e-11 42.3 0.2 2.0 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Retrotrans_gag PF03732.17 CCF49922.1 - 0.011 16.0 1.0 0.039 14.2 0.2 2.4 2 0 0 2 2 2 0 Retrotransposon gag protein zf-CCHC PF00098.23 CCF49922.1 - 0.018 15.1 0.1 0.057 13.5 0.1 1.9 1 0 0 1 1 1 0 Zinc knuckle rve_3 PF13683.6 CCF49922.1 - 0.036 13.8 0.1 0.036 13.8 0.1 2.0 2 0 0 2 2 2 0 Integrase core domain RVT_2 PF07727.14 CCF49923.1 - 2.7e-61 207.3 0.0 6.5e-61 206.0 0.0 1.7 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 CCF49923.1 - 5.4e-07 29.8 0.1 1.1e-06 28.8 0.1 1.5 1 0 0 1 1 1 1 Integrase core domain gag_pre-integrs PF13976.6 CCF49923.1 - 0.048 13.5 0.0 0.14 12.0 0.0 1.8 1 0 0 1 1 1 0 GAG-pre-integrase domain DDE_3 PF13358.6 CCF49925.1 - 5.1e-14 52.2 0.2 7.5e-14 51.7 0.2 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_Tnp_4 PF13359.6 CCF49926.1 - 2.6e-05 24.0 0.0 7.8e-05 22.4 0.0 1.8 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_Tnp_1 PF01609.21 CCF49926.1 - 0.033 13.8 0.0 0.033 13.8 0.0 1.5 2 0 0 2 2 2 0 Transposase DDE domain Orbi_VP2 PF00898.17 CCF49926.1 - 0.14 9.9 1.1 0.19 9.5 1.1 1.1 1 0 0 1 1 1 0 Orbivirus outer capsid protein VP2 Hamartin PF04388.12 CCF49928.1 - 0.12 11.0 4.8 0.12 11.1 4.8 1.0 1 0 0 1 1 1 0 Hamartin protein SOG2 PF10428.9 CCF49928.1 - 0.68 9.1 13.3 0.76 8.9 13.3 1.0 1 0 0 1 1 1 0 RAM signalling pathway protein Apt1 PF10351.9 CCF49928.1 - 1.3 7.8 4.7 1.4 7.6 4.7 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain RAP1 PF07218.11 CCF49928.1 - 2.7 6.2 5.6 2.9 6.0 5.6 1.0 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) SPX PF03105.19 CCF49928.1 - 3.2 7.6 7.7 3.4 7.5 7.7 1.1 1 0 0 1 1 1 0 SPX domain Macoilin PF09726.9 CCF49928.1 - 5.7 5.4 6.7 6.5 5.2 6.7 1.0 1 0 0 1 1 1 0 Macoilin family gag_pre-integrs PF13976.6 CCF49929.1 - 3.8e-05 23.5 3.2 0.00013 21.8 3.2 1.9 1 1 0 1 1 1 1 GAG-pre-integrase domain AAA PF00004.29 CCF49930.1 - 1.6e-44 151.6 0.1 4.5e-44 150.1 0.0 1.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 CCF49930.1 - 1.3e-08 34.6 0.2 8e-08 32.1 0.0 2.2 2 0 0 2 2 2 1 Proteasomal ATPase OB C-terminal domain AAA_5 PF07728.14 CCF49930.1 - 1.9e-08 34.4 0.7 6.4e-08 32.7 0.1 2.2 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 CCF49930.1 - 7.4e-08 32.7 0.0 1.8e-07 31.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 CCF49930.1 - 9.1e-08 32.7 0.4 8.2e-05 23.0 0.0 3.2 2 1 0 3 3 3 1 AAA ATPase domain DUF815 PF05673.13 CCF49930.1 - 4.9e-06 25.9 0.1 1.7e-05 24.1 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_lid_3 PF17862.1 CCF49930.1 - 6.2e-06 25.9 0.0 2e-05 24.3 0.0 1.9 1 0 0 1 1 1 1 AAA+ lid domain NTPase_1 PF03266.15 CCF49930.1 - 0.00018 21.5 0.1 0.0038 17.2 0.0 2.7 3 0 0 3 3 3 1 NTPase AAA_22 PF13401.6 CCF49930.1 - 0.00024 21.4 3.6 0.01 16.1 0.1 3.0 3 1 1 4 4 2 1 AAA domain RuvB_N PF05496.12 CCF49930.1 - 0.00039 20.2 0.0 0.0012 18.6 0.0 1.8 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_28 PF13521.6 CCF49930.1 - 0.00055 20.2 0.4 0.0019 18.5 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 CCF49930.1 - 0.00059 20.4 0.0 0.0028 18.2 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 CCF49930.1 - 0.001 18.8 0.3 0.003 17.3 0.3 1.9 1 1 0 1 1 1 1 AAA domain AAA_7 PF12775.7 CCF49930.1 - 0.0012 18.4 0.0 0.0073 15.8 0.0 2.0 1 1 0 1 1 1 1 P-loop containing dynein motor region AAA_14 PF13173.6 CCF49930.1 - 0.0013 18.8 0.0 0.0046 17.0 0.0 1.9 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 CCF49930.1 - 0.0022 18.4 0.0 0.0079 16.6 0.0 1.9 2 0 0 2 2 1 1 RNA helicase TsaE PF02367.17 CCF49930.1 - 0.0027 17.7 0.0 0.0056 16.7 0.0 1.5 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE TniB PF05621.11 CCF49930.1 - 0.0035 16.8 0.9 0.94 8.9 0.0 3.1 3 0 0 3 3 3 1 Bacterial TniB protein TIP49 PF06068.13 CCF49930.1 - 0.0036 16.6 0.0 0.0074 15.5 0.0 1.5 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_33 PF13671.6 CCF49930.1 - 0.005 17.0 0.0 0.011 15.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 CCF49930.1 - 0.0053 16.2 0.0 0.013 14.9 0.0 1.6 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 CCF49930.1 - 0.0082 16.0 0.0 0.019 14.8 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_11 PF13086.6 CCF49930.1 - 0.0083 15.9 0.1 0.15 11.8 0.0 2.2 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 CCF49930.1 - 0.0085 16.0 0.1 0.072 13.0 0.0 2.3 2 0 0 2 2 2 1 NACHT domain IstB_IS21 PF01695.17 CCF49930.1 - 0.013 15.3 0.1 0.036 13.8 0.0 1.9 2 0 0 2 2 2 0 IstB-like ATP binding protein HTH_Tnp_1_2 PF13022.6 CCF49930.1 - 0.017 15.3 0.1 0.045 13.9 0.1 1.7 1 0 0 1 1 1 0 Helix-turn-helix of insertion element transposase AAA_24 PF13479.6 CCF49930.1 - 0.023 14.4 0.2 0.049 13.3 0.2 1.6 1 1 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 CCF49930.1 - 0.027 14.4 1.6 0.41 10.5 0.0 2.9 2 1 0 3 3 3 0 ATPase domain predominantly from Archaea ATPase PF06745.13 CCF49930.1 - 0.037 13.4 0.0 0.2 11.0 0.0 2.1 2 0 0 2 2 2 0 KaiC Bac_DnaA PF00308.18 CCF49930.1 - 0.041 13.7 0.1 0.14 12.0 0.0 1.9 2 0 0 2 2 2 0 Bacterial dnaA protein Parvo_NS1 PF01057.17 CCF49930.1 - 0.062 12.4 0.0 0.12 11.4 0.0 1.4 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AFG1_ATPase PF03969.16 CCF49930.1 - 0.077 11.9 0.2 0.29 10.0 0.0 1.9 2 0 0 2 2 2 0 AFG1-like ATPase Sigma54_activat PF00158.26 CCF49930.1 - 0.084 12.6 0.2 1.5 8.5 0.0 2.8 3 1 0 3 3 3 0 Sigma-54 interaction domain AAA_19 PF13245.6 CCF49930.1 - 0.11 12.8 0.1 0.4 11.0 0.1 1.9 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 CCF49930.1 - 0.15 12.6 3.4 1 9.9 0.0 2.3 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.27 CCF49930.1 - 0.15 12.6 0.2 1 9.9 0.0 2.5 3 1 0 3 3 2 0 ABC transporter AAA_25 PF13481.6 CCF49930.1 - 0.24 11.0 0.1 0.24 11.0 0.1 2.1 2 1 1 3 3 3 0 AAA domain DUF2076 PF09849.9 CCF49931.1 - 2.9e-08 34.1 14.9 3.9e-08 33.7 14.9 1.2 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2076) CHCH PF06747.13 CCF49931.1 - 0.00026 21.0 6.7 0.00041 20.4 6.7 1.3 1 0 0 1 1 1 1 CHCH domain CX9C PF16860.5 CCF49931.1 - 0.037 14.1 3.8 0.086 12.9 3.8 1.6 1 0 0 1 1 1 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, RT_RNaseH PF17917.1 CCF49933.1 - 4e-14 52.8 0.1 1.4e-13 51.0 0.0 2.1 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 CCF49933.1 - 4.7e-11 42.6 0.2 4e-05 23.6 0.0 3.0 1 1 1 2 2 2 2 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 CCF49933.1 - 3.4e-09 36.7 0.3 9.8e-09 35.2 0.3 1.8 1 0 0 1 1 1 1 Integrase zinc binding domain RVT_1 PF00078.27 CCF49933.1 - 4.9e-07 29.5 0.1 1.7e-06 27.7 0.1 1.8 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC PF00098.23 CCF49935.1 - 1.1e-05 25.2 2.5 2.4e-05 24.2 2.5 1.6 1 0 0 1 1 1 1 Zinc knuckle RVT_2 PF07727.14 CCF49936.1 - 8.4e-57 192.6 0.1 2.9e-56 190.8 0.0 1.9 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 CCF49936.1 - 8.1e-16 58.3 0.1 2.5e-15 56.7 0.0 1.9 2 0 0 2 2 2 1 Integrase core domain TSP_1 PF00090.19 CCF49936.1 - 0.017 15.3 0.5 0.046 13.9 0.5 1.7 1 0 0 1 1 1 0 Thrombospondin type 1 domain HTH_Tnp_Tc3_2 PF01498.18 CCF49938.1 - 3.6e-07 30.3 2.3 4.5e-07 30.0 1.0 1.9 2 0 0 2 2 2 1 Transposase DDE_3 PF13358.6 CCF49938.1 - 9.5e-06 25.4 1.4 9.9e-06 25.4 0.3 1.6 2 0 0 2 2 2 1 DDE superfamily endonuclease HTH_23 PF13384.6 CCF49938.1 - 0.0052 16.5 0.0 0.02 14.7 0.0 2.0 1 0 0 1 1 1 1 Homeodomain-like domain GerE PF00196.19 CCF49938.1 - 0.0056 16.2 0.3 0.047 13.3 0.0 2.4 2 0 0 2 2 2 1 Bacterial regulatory proteins, luxR family HTH_Tnp_ISL3 PF13542.6 CCF49938.1 - 0.01 15.3 0.1 0.051 13.0 0.0 2.1 2 0 0 2 2 2 1 Helix-turn-helix domain of transposase family ISL3 HTH_50 PF18024.1 CCF49938.1 - 0.11 12.1 0.0 0.26 10.9 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_29 PF13551.6 CCF49938.1 - 0.12 12.5 0.0 0.99 9.5 0.0 2.4 2 0 0 2 2 2 0 Winged helix-turn helix Fungal_trans PF04082.18 CCF49939.1 - 4e-08 32.6 0.0 1.1e-07 31.2 0.0 1.7 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF49939.1 - 3.5e-06 27.0 8.8 6.3e-06 26.2 8.8 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain TetR_C_11 PF16859.5 CCF49939.1 - 0.093 13.0 5.1 2.9 8.3 0.8 3.6 3 0 0 3 3 3 0 Tetracyclin repressor-like, C-terminal domain RT_RNaseH_2 PF17919.1 CCF49941.1 - 6.1e-33 112.9 0.0 8.1e-32 109.2 0.1 2.5 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 CCF49941.1 - 2.1e-28 98.7 0.1 4.2e-28 97.7 0.1 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 CCF49941.1 - 8.9e-16 57.8 0.3 2.3e-15 56.4 0.3 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain RVT_1 PF00078.27 CCF49941.1 - 2.5e-15 56.6 0.1 6.3e-10 38.9 0.0 2.5 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 CCF49941.1 - 4.1e-15 56.0 0.0 8.7e-15 55.0 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Chromo PF00385.24 CCF49941.1 - 3.4e-12 46.1 1.0 8.4e-12 44.8 0.2 2.2 2 0 0 2 2 2 1 Chromo (CHRromatin Organisation MOdifier) domain rve_3 PF13683.6 CCF49941.1 - 0.14 12.0 0.0 0.45 10.3 0.0 1.9 1 0 0 1 1 1 0 Integrase core domain Retrotrans_gag PF03732.17 CCF49942.1 - 0.0013 19.0 0.2 0.0026 18.0 0.2 1.5 1 0 0 1 1 1 1 Retrotransposon gag protein zf-CCHC PF00098.23 CCF49942.1 - 0.17 12.0 0.9 0.38 10.9 0.9 1.6 1 0 0 1 1 1 0 Zinc knuckle DUF4939 PF16297.5 CCF49943.1 - 4.9e-11 42.5 0.0 6.6e-11 42.1 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4939) Retrotrans_gag PF03732.17 CCF49943.1 - 0.0061 16.8 0.1 0.0095 16.2 0.1 1.3 1 0 0 1 1 1 1 Retrotransposon gag protein RCC1 PF00415.18 CCF49944.1 - 1.6e-40 137.5 1.7 5.4e-06 26.9 0.4 7.9 7 1 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 CCF49944.1 - 8.1e-30 102.0 19.6 1.2e-08 34.5 0.1 7.3 7 0 0 7 7 7 5 Regulator of chromosome condensation (RCC1) repeat EBV-NA3 PF05009.12 CCF49944.1 - 0.14 11.6 2.4 0.22 11.0 2.4 1.2 1 0 0 1 1 1 0 Epstein-Barr virus nuclear antigen 3 (EBNA-3) TFIIE-A_C PF11521.8 CCF49944.1 - 0.23 11.8 1.9 0.47 10.8 1.9 1.4 1 0 0 1 1 1 0 C-terminal general transcription factor TFIIE alpha FYDLN_acid PF09538.10 CCF49944.1 - 3.3 8.4 10.0 6.5 7.5 10.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) DDE_Tnp_4 PF13359.6 CCF49945.1 - 4.7e-13 49.1 0.3 6.2e-07 29.2 0.1 2.5 1 1 1 2 2 2 2 DDE superfamily endonuclease DDE_Tnp_1 PF01609.21 CCF49945.1 - 0.0016 18.1 0.1 0.0046 16.6 0.1 1.8 1 1 0 1 1 1 1 Transposase DDE domain EnY2 PF10163.9 CCF49947.1 - 0.0061 16.9 0.2 0.1 13.0 0.1 2.3 2 0 0 2 2 2 1 Transcription factor e(y)2 Adeno_VII PF03228.14 CCF49947.1 - 0.02 15.5 0.5 0.036 14.7 0.5 1.3 1 0 0 1 1 1 0 Adenoviral core protein VII CUT PF02376.15 CCF49947.1 - 0.045 13.9 0.0 0.084 13.0 0.0 1.4 1 0 0 1 1 1 0 CUT domain DUF883 PF05957.13 CCF49947.1 - 0.083 13.5 0.9 0.24 12.0 0.9 1.9 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF883) OPA3 PF07047.12 CCF49948.1 - 7.6e-43 145.3 2.1 1.4e-42 144.4 2.1 1.5 1 0 0 1 1 1 1 Optic atrophy 3 protein (OPA3) Nrap_D5 PF17406.2 CCF49948.1 - 0.06 13.1 0.0 0.12 12.1 0.0 1.6 1 0 0 1 1 1 0 Nrap protein PAP/OAS1-like domain 5 DUF1931 PF09123.11 CCF49950.1 - 0.079 13.1 0.0 0.11 12.6 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1931) DUF5110 PF17137.4 CCF49950.1 - 0.084 13.2 0.1 0.5 10.7 0.0 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF5110) LPD3 PF18798.1 CCF49950.1 - 0.13 12.5 0.1 0.21 11.8 0.1 1.3 1 0 0 1 1 1 0 Large polyvalent protein-associated domain 3 Defensin_beta PF00711.19 CCF49951.1 - 0.0065 16.5 0.4 0.016 15.2 0.4 1.6 1 0 0 1 1 1 1 Beta defensin RT_RNaseH PF17917.1 CCF49952.1 - 3.9e-35 120.3 0.2 7.6e-35 119.4 0.2 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 CCF49952.1 - 1e-32 112.2 0.0 5.5e-32 109.8 0.1 2.1 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 CCF49952.1 - 2.5e-28 99.1 0.1 5.4e-28 98.0 0.1 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Clp_N PF02861.20 CCF49952.1 - 0.22 11.6 0.2 0.22 11.6 0.2 1.8 2 0 0 2 2 2 0 Clp amino terminal domain, pathogenicity island component zf-CCHC PF00098.23 CCF49953.1 - 3.9e-06 26.7 2.1 6.7e-06 25.9 2.1 1.4 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_2 PF13696.6 CCF49953.1 - 0.0047 16.7 3.5 0.0085 15.9 3.5 1.4 1 0 0 1 1 1 1 Zinc knuckle eIF3g PF12353.8 CCF49953.1 - 0.012 16.0 0.6 0.012 16.0 0.6 2.0 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit G zf-CCHC_5 PF14787.6 CCF49953.1 - 0.025 14.3 1.8 0.058 13.1 1.8 1.6 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger zf-CCHC_6 PF15288.6 CCF49953.1 - 0.066 13.1 1.2 0.2 11.5 1.2 1.8 1 0 0 1 1 1 0 Zinc knuckle Sec2p PF06428.11 CCF49954.1 - 5.5e-18 64.7 8.4 5.5e-18 64.7 8.4 3.8 3 1 0 3 3 3 1 GDP/GTP exchange factor Sec2p DUF948 PF06103.11 CCF49954.1 - 1.2 9.5 5.8 11 6.3 0.3 3.3 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) PH_9 PF15410.6 CCF49955.1 - 2.7e-30 105.2 0.0 5.4e-30 104.2 0.0 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain Sec7 PF01369.20 CCF49955.1 - 5.6e-30 104.4 0.1 1.5e-29 103.0 0.0 1.6 2 0 0 2 2 2 1 Sec7 domain PH PF00169.29 CCF49955.1 - 0.0001 22.8 0.0 0.00039 20.9 0.0 2.0 1 1 0 1 1 1 1 PH domain Glyco_transf_20 PF00982.21 CCF49956.1 - 4.4e-151 503.8 0.0 6.3e-151 503.3 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.16 CCF49956.1 - 1.2e-18 67.1 0.0 2.3e-18 66.2 0.0 1.4 1 0 0 1 1 1 1 Trehalose-phosphatase RVT_2 PF07727.14 CCF49957.1 - 1.6e-49 168.7 0.1 2.9e-49 167.9 0.1 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 CCF49958.1 - 3.1e-11 43.5 0.0 5.2e-11 42.8 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain gag_pre-integrs PF13976.6 CCF49958.1 - 1.3e-05 24.9 3.0 3.8e-05 23.5 3.0 1.8 1 0 0 1 1 1 1 GAG-pre-integrase domain Ipi1_N PF12333.8 CCF49959.1 - 0.043 14.4 0.1 0.061 13.9 0.1 1.3 1 0 0 1 1 1 0 Rix1 complex component involved in 60S ribosome maturation DDE_Tnp_4 PF13359.6 CCF49960.1 - 8.4e-06 25.5 0.0 1.1e-05 25.1 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease SH3_2 PF07653.17 CCF49960.1 - 0.14 11.9 0.0 0.52 10.0 0.0 2.0 1 1 0 1 1 1 0 Variant SH3 domain Cupin_5 PF06172.11 CCF49961.1 - 4.9e-32 111.0 0.0 3e-31 108.5 0.0 1.9 1 1 0 1 1 1 1 Cupin superfamily (DUF985) Mito_carr PF00153.27 CCF49963.1 - 3.1e-17 62.3 5.0 1.8e-05 24.5 0.0 5.6 5 1 0 5 5 5 5 Mitochondrial carrier protein UPF0561 PF10573.9 CCF49963.1 - 0.44 10.7 3.1 0.59 10.3 1.1 2.2 1 1 1 2 2 2 0 Uncharacterised protein family UPF0561 GAGE PF05831.11 CCF49963.1 - 1.8 9.1 10.5 0.16 12.5 5.1 1.9 2 0 0 2 2 2 0 GAGE protein Sec7_N PF12783.7 CCF49965.1 - 2.1e-44 151.2 1.0 2.1e-44 151.2 1.0 3.2 3 0 0 3 3 3 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DCB PF16213.5 CCF49965.1 - 2.9e-36 124.8 2.1 7.3e-36 123.5 2.1 1.8 1 0 0 1 1 1 1 Dimerisation and cyclophilin-binding domain of Mon2 Mon2_C PF16206.5 CCF49965.1 - 2.9e-24 85.3 6.1 6.3e-14 51.1 1.1 3.2 2 1 1 3 3 3 3 C-terminal region of Mon2 protein DUF1981 PF09324.10 CCF49965.1 - 0.00017 21.4 0.1 0.0029 17.4 0.0 2.7 2 0 0 2 2 2 1 Domain of unknown function (DUF1981) RVT_2 PF07727.14 CCF49968.1 - 4.3e-14 52.8 0.0 4.8e-14 52.6 0.0 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) NAD_kinase PF01513.21 CCF49969.1 - 3e-73 246.6 0.0 1e-72 244.8 0.0 1.8 1 1 0 1 1 1 1 ATP-NAD kinase NOA36 PF06524.12 CCF49969.1 - 6.3 6.0 35.3 0.04 13.2 15.8 2.4 2 0 0 2 2 2 0 NOA36 protein RVT_2 PF07727.14 CCF49970.1 - 5.2e-62 209.6 0.3 1.1e-61 208.5 0.0 1.8 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 CCF49970.1 - 1e-15 57.9 0.1 3e-15 56.5 0.0 1.9 2 0 0 2 2 2 1 Integrase core domain gag_pre-integrs PF13976.6 CCF49970.1 - 1.7e-07 31.0 0.4 4.7e-07 29.6 0.4 1.8 1 0 0 1 1 1 1 GAG-pre-integrase domain RVT_2 PF07727.14 CCF49971.1 - 1.9e-14 53.9 0.0 2.4e-14 53.6 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.27 CCF49973.1 - 5.8e-29 101.2 0.0 1.1e-28 100.3 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 CCF49973.1 - 1.4e-19 70.3 0.9 3.2e-19 69.2 0.3 1.9 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 CCF49973.1 - 5.3e-19 68.1 0.4 1.3e-18 66.9 0.4 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 CCF49973.1 - 8.5e-15 55.0 0.0 2e-14 53.8 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain Chromo PF00385.24 CCF49973.1 - 6.2e-12 45.2 0.2 2e-11 43.6 0.2 2.0 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain RT_RNaseH_2 PF17919.1 CCF49973.1 - 4.7e-11 42.6 0.2 2.5e-06 27.4 0.0 3.0 1 1 1 2 2 2 2 RNase H-like domain found in reverse transcriptase gag-asp_proteas PF13975.6 CCF49973.1 - 5.1e-09 36.6 0.1 1.1e-08 35.5 0.1 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease RVP_2 PF08284.11 CCF49973.1 - 1.2e-08 34.8 0.0 3.4e-08 33.3 0.0 1.7 2 0 0 2 2 2 1 Retroviral aspartyl protease Asp_protease_2 PF13650.6 CCF49973.1 - 1.7e-08 35.0 0.2 4.1e-08 33.8 0.2 1.7 1 0 0 1 1 1 1 Aspartyl protease Retrotrans_gag PF03732.17 CCF49973.1 - 0.0027 17.9 0.1 0.012 15.9 0.1 2.1 1 0 0 1 1 1 1 Retrotransposon gag protein RVP PF00077.20 CCF49973.1 - 0.017 15.4 0.1 0.041 14.2 0.1 1.6 1 0 0 1 1 1 0 Retroviral aspartyl protease Asp_protease PF09668.10 CCF49973.1 - 0.11 12.3 0.0 0.21 11.4 0.0 1.4 1 0 0 1 1 1 0 Aspartyl protease RT_RNaseH PF17917.1 CCF49977.1 - 7.6e-32 109.7 0.7 1.4e-31 108.9 0.1 1.7 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 CCF49977.1 - 2.1e-30 104.7 0.1 5.1e-30 103.5 0.1 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 CCF49977.1 - 1.9e-20 73.3 0.2 3.4e-20 72.5 0.2 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Rad21_Rec8_N PF04825.13 CCF49979.1 - 0.042 14.0 0.0 0.068 13.3 0.0 1.3 1 1 0 1 1 1 0 N terminus of Rad21 / Rec8 like protein EFF-AFF PF14884.6 CCF49979.1 - 0.079 11.1 0.1 0.1 10.7 0.1 1.2 1 0 0 1 1 1 0 Type I membrane glycoproteins cell-cell fusogen DDE_Tnp_4 PF13359.6 CCF49980.1 - 1e-09 38.2 0.0 1.2e-09 38.0 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_Tnp_1 PF01609.21 CCF49980.1 - 6.6e-05 22.7 0.0 9.4e-05 22.2 0.0 1.2 1 0 0 1 1 1 1 Transposase DDE domain NUDIX_2 PF13869.6 CCF49982.1 - 1.8e-72 242.9 0.0 2.2e-72 242.6 0.0 1.1 1 0 0 1 1 1 1 Nucleotide hydrolase TBP PF00352.21 CCF49983.1 - 4.2e-66 218.9 0.2 2.4e-32 110.7 0.1 2.1 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) DUF3378 PF11858.8 CCF49983.1 - 1.2e-05 25.3 0.0 0.19 11.8 0.0 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF3378) DUF4295 PF14128.6 CCF49983.1 - 0.12 12.2 0.1 0.63 9.9 0.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4295) Ferric_reduct PF01794.19 CCF49984.1 - 7e-19 68.2 7.9 7e-19 68.2 7.9 3.5 4 0 0 4 4 4 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.12 CCF49984.1 - 6.2e-16 58.4 0.0 1.8e-15 57.0 0.0 1.8 2 0 0 2 2 2 1 FAD-binding domain NAD_binding_6 PF08030.12 CCF49984.1 - 1e-15 58.2 0.0 3.2e-15 56.6 0.0 1.8 1 1 0 1 1 1 1 Ferric reductase NAD binding domain NAD_binding_1 PF00175.21 CCF49984.1 - 0.00025 21.6 0.0 1.1 10.0 0.0 2.4 2 0 0 2 2 2 2 Oxidoreductase NAD-binding domain DUF3328 PF11807.8 CCF49984.1 - 1.7 8.4 4.4 1.4 8.6 0.1 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF3328) Retrotrans_gag PF03732.17 CCF49986.1 - 0.00017 21.8 0.2 0.0004 20.6 0.2 1.7 1 0 0 1 1 1 1 Retrotransposon gag protein zf-rbx1 PF12678.7 CCF49991.1 - 9.7e-13 48.2 1.5 2.4e-12 46.9 1.5 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 CCF49991.1 - 2.9e-07 30.7 9.4 2.9e-07 30.7 9.4 2.5 2 1 0 2 2 1 1 Ring finger domain zf-C3HC4 PF00097.25 CCF49991.1 - 3.6e-07 29.9 0.4 9.4e-07 28.6 0.4 1.8 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CCF49991.1 - 3.6e-06 26.9 0.2 3.6e-06 26.9 0.2 1.9 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 CCF49991.1 - 5.3e-06 26.2 3.2 5.3e-06 26.2 3.2 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 CCF49991.1 - 7.2e-05 22.6 2.0 0.00019 21.3 2.1 1.7 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 CCF49991.1 - 8.5e-05 22.3 3.0 0.0016 18.3 1.4 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CCF49991.1 - 0.00016 21.5 3.7 0.00062 19.7 3.9 1.9 1 1 1 2 2 2 1 zinc-RING finger domain Zn_ribbon_17 PF17120.5 CCF49991.1 - 0.00016 21.2 0.8 0.00042 19.9 0.8 1.6 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-C3HC4_4 PF15227.6 CCF49991.1 - 0.0023 18.1 2.5 0.0038 17.3 1.3 1.9 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-ANAPC11 PF12861.7 CCF49991.1 - 0.003 17.6 4.7 0.014 15.5 4.7 2.0 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_11 PF17123.5 CCF49991.1 - 0.0031 17.2 0.3 0.0031 17.2 0.3 2.5 3 0 0 3 3 3 1 RING-like zinc finger FANCL_C PF11793.8 CCF49991.1 - 0.0037 17.4 0.4 0.0079 16.3 0.4 1.6 1 0 0 1 1 1 1 FANCL C-terminal domain Cid2 PF09774.9 CCF49991.1 - 0.016 15.7 0.8 0.032 14.7 0.8 1.5 1 0 0 1 1 1 0 Caffeine-induced death protein 2 Colicin_K PF17500.2 CCF49991.1 - 0.13 12.8 1.1 0.3 11.7 1.1 1.6 1 0 0 1 1 1 0 Colicin-K zf-RING-like PF08746.11 CCF49991.1 - 0.26 11.6 3.0 0.53 10.6 3.0 1.5 1 0 0 1 1 1 0 RING-like domain SET PF00856.28 CCF49992.1 - 3.6e-10 40.5 0.0 4.8e-09 36.8 0.0 2.6 2 1 0 2 2 2 1 SET domain FYDLN_acid PF09538.10 CCF49992.1 - 0.019 15.6 0.2 0.019 15.6 0.2 4.8 4 1 0 4 4 4 0 Protein of unknown function (FYDLN_acid) RVT_2 PF07727.14 CCF49993.1 - 5.9e-05 22.8 0.3 0.00012 21.8 0.1 1.6 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC PF00098.23 CCF49995.1 - 0.0084 16.1 0.1 0.014 15.5 0.1 1.4 1 0 0 1 1 1 1 Zinc knuckle Clp_N PF02861.20 CCF49995.1 - 0.18 12.0 0.1 0.35 11.0 0.1 1.5 1 0 0 1 1 1 0 Clp amino terminal domain, pathogenicity island component GDA1_CD39 PF01150.17 CCF49998.1 - 4.2e-91 305.7 0.0 5.6e-91 305.3 0.0 1.1 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family Ppx-GppA PF02541.16 CCF49998.1 - 0.023 14.2 0.0 0.038 13.4 0.0 1.2 1 0 0 1 1 1 0 Ppx/GppA phosphatase family MSP1a PF11670.8 CCF49998.1 - 0.16 11.3 0.1 0.27 10.5 0.1 1.3 1 0 0 1 1 1 0 Major surface protein 1a (MSP1a) Ribosomal_L1 PF00687.21 CCF49998.1 - 0.17 11.6 0.0 0.89 9.2 0.0 1.9 2 0 0 2 2 2 0 Ribosomal protein L1p/L10e family P5CR_dimer PF14748.6 CCF49999.1 - 5.2e-37 126.2 3.5 5.2e-37 126.2 3.5 1.7 2 0 0 2 2 2 1 Pyrroline-5-carboxylate reductase dimerisation F420_oxidored PF03807.17 CCF49999.1 - 3.2e-14 53.3 0.9 4e-12 46.6 0.9 2.5 1 1 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent zf-CCHC PF00098.23 CCF50002.1 - 0.00018 21.4 0.8 0.00018 21.4 0.8 1.7 2 0 0 2 2 2 1 Zinc knuckle Ion_trans PF00520.31 CCF50003.1 - 0.0017 17.6 0.0 0.0022 17.2 0.0 1.1 1 0 0 1 1 1 1 Ion transport protein Mcm10 PF09332.11 CCF50005.1 - 0.13 11.6 1.9 0.21 11.0 1.9 1.2 1 0 0 1 1 1 0 Mcm10 replication factor DUF1213 PF06740.12 CCF50006.1 - 0.13 12.9 3.7 2.4 8.8 0.1 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1213) Drc1-Sld2 PF11719.8 CCF50007.1 - 2e-10 40.8 12.2 2e-10 40.8 12.2 3.0 2 1 0 2 2 2 1 DNA replication and checkpoint protein rve PF00665.26 CCF50011.1 - 0.00045 20.4 0.0 0.0011 19.1 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain RT_RNaseH PF17917.1 CCF50011.1 - 0.0035 17.6 0.0 0.013 15.8 0.0 2.0 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase zf-RING_5 PF14634.6 CCF50014.1 - 0.0019 18.1 0.1 0.0019 18.1 0.1 1.8 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_2 PF13639.6 CCF50014.1 - 0.058 13.7 0.8 0.058 13.7 0.8 1.7 2 0 0 2 2 2 0 Ring finger domain RVT_1 PF00078.27 CCF50016.1 - 5.9e-30 104.4 0.0 1.3e-29 103.3 0.0 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 CCF50016.1 - 1.1e-17 64.2 0.1 2.7e-17 63.0 0.1 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 CCF50016.1 - 1.8e-17 63.2 0.6 1.9e-09 37.5 0.1 2.6 1 1 1 2 2 2 2 RNase H-like domain found in reverse transcriptase rve PF00665.26 CCF50016.1 - 5.9e-17 62.0 0.0 6.4e-16 58.6 0.0 2.4 2 0 0 2 2 2 1 Integrase core domain gag-asp_proteas PF13975.6 CCF50016.1 - 2.8e-09 37.4 0.1 5.3e-09 36.5 0.1 1.5 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease RVP_2 PF08284.11 CCF50016.1 - 1.5e-08 34.5 0.0 3.6e-08 33.3 0.0 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease_2 PF13650.6 CCF50016.1 - 2.1e-08 34.7 0.2 4.3e-08 33.7 0.2 1.5 1 0 0 1 1 1 1 Aspartyl protease Retrotrans_gag PF03732.17 CCF50016.1 - 0.0019 18.5 0.1 0.007 16.6 0.1 2.0 1 0 0 1 1 1 1 Retrotransposon gag protein zf-CCHC PF00098.23 CCF50016.1 - 0.0089 16.1 1.9 0.021 14.9 1.9 1.7 1 0 0 1 1 1 1 Zinc knuckle RVP PF00077.20 CCF50016.1 - 0.014 15.7 0.1 0.03 14.6 0.1 1.6 1 0 0 1 1 1 0 Retroviral aspartyl protease Asp_protease PF09668.10 CCF50016.1 - 0.054 13.3 0.0 0.099 12.4 0.0 1.4 1 0 0 1 1 1 0 Aspartyl protease Ribosomal_L30 PF00327.20 CCF50017.1 - 2.1e-10 40.3 0.0 3.2e-10 39.7 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e DUF3275 PF11679.8 CCF50018.1 - 0.91 9.5 2.9 1 9.3 2.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3275) Miga PF10265.9 CCF50018.1 - 5.4 5.9 6.2 6.2 5.7 6.2 1.0 1 0 0 1 1 1 0 Mitoguardin UPF0449 PF15136.6 CCF50019.1 - 0.078 13.5 0.0 0.16 12.5 0.0 1.5 1 0 0 1 1 1 0 Uncharacterised protein family UPF0449 DDE_Tnp_4 PF13359.6 CCF50020.1 - 2.4e-21 76.1 0.0 5e-21 75.0 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease RVT_2 PF07727.14 CCF50021.1 - 9.8e-63 212.0 0.3 2e-62 211.0 0.0 1.7 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 CCF50021.1 - 1.6e-12 47.7 0.0 5e-12 46.1 0.0 1.9 2 0 0 2 2 2 1 Integrase core domain gag_pre-integrs PF13976.6 CCF50021.1 - 2.5e-07 30.4 0.2 7.3e-07 29.0 0.2 1.8 1 0 0 1 1 1 1 GAG-pre-integrase domain zf-CCHC PF00098.23 CCF50021.1 - 6.2e-05 22.9 3.2 6.2e-05 22.9 3.2 2.1 2 0 0 2 2 2 1 Zinc knuckle Asp_protease_2 PF13650.6 CCF50021.1 - 0.082 13.6 0.3 0.27 11.9 0.1 2.1 2 0 0 2 2 2 0 Aspartyl protease gag-asp_proteas PF13975.6 CCF50021.1 - 0.11 13.1 0.5 0.76 10.4 0.1 2.6 3 0 0 3 3 3 0 gag-polyprotein putative aspartyl protease RVT_2 PF07727.14 CCF50026.1 - 5.8e-59 199.7 0.1 1.6e-58 198.2 0.0 1.8 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 CCF50026.1 - 8.6e-14 51.7 0.1 2.6e-13 50.2 0.0 1.9 2 0 0 2 2 2 1 Integrase core domain gag_pre-integrs PF13976.6 CCF50026.1 - 1.1e-07 31.5 0.4 3.5e-07 30.0 0.4 1.9 1 0 0 1 1 1 1 GAG-pre-integrase domain zf-CCHC PF00098.23 CCF50026.1 - 2.2e-05 24.3 3.2 6.2e-05 22.9 3.2 1.8 1 0 0 1 1 1 1 Zinc knuckle Asp_protease_2 PF13650.6 CCF50026.1 - 0.072 13.7 0.1 0.28 11.8 0.1 2.0 1 0 0 1 1 1 0 Aspartyl protease RabGAP-TBC PF00566.18 CCF50027.1 - 5.1e-36 124.4 0.0 8.6e-36 123.6 0.0 1.4 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Pkinase PF00069.25 CCF50028.1 - 8.7e-62 208.9 0.0 1.6e-61 208.0 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF50028.1 - 1.7e-24 86.5 0.0 2.3e-24 86.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCF50028.1 - 6.1e-05 22.5 0.0 0.00015 21.2 0.0 1.6 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 CCF50028.1 - 0.0043 17.0 0.2 0.03 14.2 0.0 2.2 2 1 0 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 CCF50028.1 - 0.034 13.7 0.0 0.054 13.1 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase DUF1679 PF07914.11 CCF50028.1 - 0.072 11.9 0.1 0.12 11.2 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1679) FTA2 PF13095.6 CCF50028.1 - 0.093 12.3 0.0 0.21 11.2 0.0 1.7 1 1 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 CCF50028.1 - 0.12 11.7 0.0 0.2 11.0 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Tannase PF07519.11 CCF50029.1 - 3.9e-80 270.0 0.1 5e-43 147.7 0.3 2.4 2 0 0 2 2 2 2 Tannase and feruloyl esterase Hydrolase_4 PF12146.8 CCF50029.1 - 0.00031 20.1 0.0 0.00085 18.7 0.0 1.7 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 CCF50029.1 - 0.016 14.7 0.0 0.47 9.9 0.1 2.2 2 0 0 2 2 2 0 Prolyl oligopeptidase family Glyco_hydro_38N PF01074.22 CCF50030.1 - 1.5e-78 264.1 1.2 2.2e-78 263.6 1.2 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 N-terminal domain Glyco_hydro_38C PF07748.13 CCF50030.1 - 1.2e-44 153.0 0.0 1.9e-44 152.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal domain Alpha-mann_mid PF09261.11 CCF50030.1 - 1.2e-28 99.1 0.0 2.5e-28 98.1 0.0 1.6 1 0 0 1 1 1 1 Alpha mannosidase middle domain Glyco_hydro38C2 PF17677.1 CCF50030.1 - 7.4e-12 45.2 0.2 2.3e-11 43.7 0.2 1.9 1 1 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal beta sandwich domain Glyco_hydro_57 PF03065.15 CCF50030.1 - 0.0024 17.1 0.0 0.0041 16.4 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 57 Mcm10 PF09332.11 CCF50032.1 - 0.24 10.8 3.4 0.44 9.9 3.4 1.3 1 0 0 1 1 1 0 Mcm10 replication factor DDE_Tnp_4 PF13359.6 CCF50033.1 - 6.8e-18 64.8 0.0 1.2e-17 64.1 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease zf-CCHC PF00098.23 CCF50034.1 - 1.4e-05 24.9 1.8 2.6e-05 24.1 1.8 1.5 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_2 PF13696.6 CCF50034.1 - 9.8e-05 22.1 2.3 0.00022 21.0 2.3 1.6 1 0 0 1 1 1 1 Zinc knuckle BRCT_3 PF18428.1 CCF50034.1 - 0.04 14.0 0.0 0.13 12.4 0.0 1.9 1 0 0 1 1 1 0 BRCA1 C Terminus (BRCT) domain eIF3g PF12353.8 CCF50034.1 - 0.053 13.9 1.1 0.16 12.4 1.1 1.8 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit G RT_RNaseH_2 PF17919.1 CCF50035.1 - 1.3e-27 95.8 0.0 3e-27 94.6 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 CCF50035.1 - 1.5e-25 89.5 0.0 5.3e-25 87.7 0.0 1.9 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 CCF50035.1 - 2.1e-24 86.3 0.5 4.1e-24 85.3 0.5 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_2 PF07727.14 CCF50039.1 - 6.4e-32 111.1 0.0 9e-32 110.6 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 CCF50039.1 - 0.049 13.8 0.0 0.13 12.4 0.0 1.7 2 0 0 2 2 2 0 Integrase core domain DUF1440 PF07274.12 CCF50040.1 - 0.0094 16.3 0.7 0.29 11.5 0.1 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF1440) Lipid_DES PF08557.10 CCF50040.1 - 0.14 11.7 0.2 0.34 10.4 0.2 1.7 1 1 0 1 1 1 0 Sphingolipid Delta4-desaturase (DES) NARP1 PF12569.8 CCF50041.1 - 1.5e-157 525.6 4.7 1.5e-157 525.6 4.7 1.9 2 0 0 2 2 2 1 NMDA receptor-regulated protein 1 TPR_2 PF07719.17 CCF50041.1 - 7.6e-10 38.1 33.0 1.2e-06 28.1 0.1 10.1 11 1 1 12 12 10 2 Tetratricopeptide repeat TPR_1 PF00515.28 CCF50041.1 - 1.4e-09 37.3 3.5 5.5e-06 26.0 0.2 5.5 7 0 0 7 7 5 1 Tetratricopeptide repeat TPR_19 PF14559.6 CCF50041.1 - 6.5e-09 36.2 16.6 0.14 12.7 0.2 9.0 7 2 3 10 10 9 3 Tetratricopeptide repeat TPR_7 PF13176.6 CCF50041.1 - 5.2e-08 32.4 3.3 1.5e-05 24.6 0.1 5.4 6 0 0 6 6 4 1 Tetratricopeptide repeat TPR_16 PF13432.6 CCF50041.1 - 6.3e-08 33.1 21.1 0.086 13.5 0.0 10.1 10 2 2 12 12 10 2 Tetratricopeptide repeat TPR_12 PF13424.6 CCF50041.1 - 1.5e-06 28.4 18.2 0.0021 18.3 0.0 7.0 7 1 1 8 8 7 3 Tetratricopeptide repeat TPR_10 PF13374.6 CCF50041.1 - 6.3e-05 22.7 3.9 0.25 11.3 0.1 5.2 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_MalT PF17874.1 CCF50041.1 - 9.3e-05 22.0 6.7 0.045 13.1 0.2 4.4 4 1 0 4 4 4 2 MalT-like TPR region TPR_8 PF13181.6 CCF50041.1 - 0.00037 20.5 17.6 0.00039 20.4 0.1 6.8 9 0 0 9 9 7 1 Tetratricopeptide repeat ANAPC3 PF12895.7 CCF50041.1 - 0.00078 19.6 4.8 0.29 11.4 0.1 5.4 5 1 0 5 5 5 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.6 CCF50041.1 - 0.0013 19.4 28.1 0.43 11.5 0.0 10.6 11 2 2 13 13 10 1 Tetratricopeptide repeat TPR_6 PF13174.6 CCF50041.1 - 0.0021 18.6 21.3 1.2 9.9 0.0 9.8 11 1 1 12 12 9 1 Tetratricopeptide repeat TPR_11 PF13414.6 CCF50041.1 - 0.0072 16.0 0.9 0.039 13.6 0.1 2.7 2 0 0 2 2 2 1 TPR repeat TPR_9 PF13371.6 CCF50041.1 - 0.021 15.0 2.4 16 5.8 0.0 4.7 4 1 1 5 5 4 0 Tetratricopeptide repeat DUF5588 PF17826.1 CCF50041.1 - 0.031 13.2 0.0 0.076 11.9 0.0 1.6 2 0 0 2 2 2 0 Family of unknown function (DUF5588) TPR_4 PF07721.14 CCF50041.1 - 0.062 13.9 22.1 0.68 10.7 0.8 7.4 8 0 0 8 8 6 0 Tetratricopeptide repeat TPR_17 PF13431.6 CCF50041.1 - 0.064 13.7 3.1 63 4.3 0.0 5.8 6 0 0 6 6 5 0 Tetratricopeptide repeat MerR_2 PF13591.6 CCF50041.1 - 0.12 12.2 0.2 0.42 10.5 0.1 1.9 2 0 0 2 2 1 0 MerR HTH family regulatory protein PPR PF01535.20 CCF50041.1 - 0.18 12.1 3.2 17 6.0 0.1 5.2 6 0 0 6 6 4 0 PPR repeat Homeodomain PF00046.29 CCF50042.1 - 2e-07 30.7 3.1 1.7e-06 27.8 3.1 2.4 1 1 0 1 1 1 1 Homeodomain DDE_3 PF13358.6 CCF50042.1 - 0.019 14.7 0.4 0.042 13.6 0.4 1.5 1 0 0 1 1 1 0 DDE superfamily endonuclease Homeobox_KN PF05920.11 CCF50042.1 - 0.059 13.3 0.1 0.18 11.7 0.1 1.8 1 0 0 1 1 1 0 Homeobox KN domain SMBP PF16785.5 CCF50042.1 - 0.15 12.3 1.1 0.27 11.5 1.1 1.4 1 0 0 1 1 1 0 Small metal-binding protein Ustilago_mating PF05722.12 CCF50043.1 - 1.4e-186 618.7 7.4 2.1e-186 618.2 7.4 1.2 1 0 0 1 1 1 1 Ustilago B locus mating-type protein Homeobox_KN PF05920.11 CCF50043.1 - 6.3e-19 67.6 2.3 7.6e-18 64.1 1.1 3.1 2 1 0 2 2 2 1 Homeobox KN domain Sas10_Utp3 PF04000.15 CCF50044.1 - 2.8e-17 63.1 0.4 2.8e-17 63.1 0.4 2.0 2 0 0 2 2 2 1 Sas10/Utp3/C1D family Uds1 PF15456.6 CCF50046.1 - 4e-38 130.5 8.3 4e-38 130.5 8.3 9.3 5 1 3 8 8 8 1 Up-regulated During Septation ERM PF00769.19 CCF50046.1 - 0.0018 18.1 15.3 0.0018 18.1 15.3 7.4 5 2 1 6 6 6 2 Ezrin/radixin/moesin family COPIIcoated_ERV PF07970.12 CCF50047.1 - 2.1e-84 282.8 0.0 2.8e-84 282.4 0.0 1.2 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 CCF50047.1 - 6.1e-28 97.0 0.2 1.3e-27 95.9 0.0 1.7 2 0 0 2 2 2 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Sh_2 PF17512.2 CCF50047.1 - 0.054 13.3 0.0 0.11 12.3 0.0 1.4 1 0 0 1 1 1 0 Metapneumovirus Small hydrophobic protein ACOX PF01756.19 CCF50048.1 - 9.7e-46 155.6 0.0 1.7e-45 154.8 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA oxidase Acyl-CoA_dh_M PF02770.19 CCF50048.1 - 1.5e-19 69.9 0.0 3.6e-19 68.7 0.0 1.7 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_ox_N PF14749.6 CCF50048.1 - 1.1e-10 42.1 0.1 6.2e-10 39.7 0.0 2.4 2 0 0 2 2 2 1 Acyl-coenzyme A oxidase N-terminal Acyl-CoA_dh_1 PF00441.24 CCF50048.1 - 4.6e-08 33.4 0.6 1.7e-06 28.3 1.1 3.0 2 1 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Glyco_hydro_43 PF04616.14 CCF50049.1 - 7.5e-34 117.3 0.0 8.8e-34 117.1 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 CTP_transf_1 PF01148.20 CCF50050.1 - 0.0034 17.2 0.8 0.0045 16.8 0.8 1.4 1 0 0 1 1 1 1 Cytidylyltransferase family Semialdhyde_dhC PF02774.18 CCF50052.1 - 3.2e-44 151.2 0.0 4.9e-44 150.6 0.0 1.3 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, dimerisation domain Semialdhyde_dh PF01118.24 CCF50052.1 - 1.4e-26 93.3 0.0 2.4e-26 92.5 0.0 1.4 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain DapB_N PF01113.20 CCF50052.1 - 0.01 16.0 0.0 0.022 14.9 0.0 1.6 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus Gp_dh_C PF02800.20 CCF50052.1 - 0.029 14.0 0.0 0.062 12.9 0.0 1.5 1 0 0 1 1 1 0 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain DXP_reductoisom PF02670.16 CCF50052.1 - 0.099 13.4 0.0 0.31 11.7 0.0 1.9 2 0 0 2 2 2 0 1-deoxy-D-xylulose 5-phosphate reductoisomerase Hira PF07569.11 CCF50053.1 - 1.2e-50 172.3 0.0 1.4e-49 168.8 0.0 2.2 2 0 0 2 2 2 1 TUP1-like enhancer of split WD40 PF00400.32 CCF50053.1 - 1.5e-27 95.3 21.7 2.3e-06 28.2 0.0 9.1 9 0 0 9 9 9 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF50053.1 - 1.7e-10 41.1 1.6 0.39 11.1 0.0 6.3 4 2 3 7 7 7 3 Anaphase-promoting complex subunit 4 WD40 domain HIRA_B PF09453.10 CCF50053.1 - 6.4e-09 35.5 1.7 1.9e-08 33.9 1.7 1.9 1 0 0 1 1 1 1 HIRA B motif Ge1_WD40 PF16529.5 CCF50053.1 - 0.0051 15.8 0.5 8.3 5.3 0.0 3.8 3 1 1 4 4 4 1 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 CCF50053.1 - 0.015 15.2 4.3 1 9.4 0.2 4.3 4 1 0 4 4 4 0 WD40-like Beta Propeller Repeat Nup160 PF11715.8 CCF50053.1 - 0.22 10.2 5.0 7.2 5.1 0.1 3.1 2 1 1 3 3 3 0 Nucleoporin Nup120/160 Choline_kinase PF01633.20 CCF50054.1 - 9.1e-35 120.2 0.0 8.6e-22 77.8 0.0 3.0 3 1 0 3 3 3 2 Choline/ethanolamine kinase APH PF01636.23 CCF50054.1 - 0.00043 20.3 0.3 0.07 13.0 0.0 2.7 2 1 0 2 2 2 2 Phosphotransferase enzyme family Pkinase PF00069.25 CCF50055.1 - 3.8e-74 249.4 0.0 4.6e-74 249.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF50055.1 - 8.1e-32 110.5 0.0 1.1e-31 110.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCF50055.1 - 1.5e-05 24.4 0.1 0.0031 16.9 0.0 2.2 2 0 0 2 2 2 2 Kinase-like APH PF01636.23 CCF50055.1 - 0.015 15.2 1.1 0.066 13.1 0.0 2.2 2 0 0 2 2 2 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 CCF50055.1 - 0.015 14.3 0.1 1.7 7.5 0.0 2.1 2 0 0 2 2 2 0 Haspin like kinase domain CoaE PF01121.20 CCF50056.1 - 2.5e-53 180.4 0.0 3.1e-53 180.1 0.0 1.1 1 0 0 1 1 1 1 Dephospho-CoA kinase AAA_18 PF13238.6 CCF50056.1 - 0.0007 20.2 0.0 0.002 18.7 0.0 1.7 1 1 0 1 1 1 1 AAA domain UBX PF00789.20 CCF50057.1 - 2.6e-06 27.6 0.0 8e-06 26.0 0.0 1.8 2 0 0 2 2 2 1 UBX domain UBA PF00627.31 CCF50057.1 - 0.0021 17.9 0.0 0.0069 16.3 0.0 1.9 1 0 0 1 1 1 1 UBA/TS-N domain Jas PF16135.5 CCF50057.1 - 0.067 13.4 0.8 0.13 12.4 0.0 1.8 2 0 0 2 2 2 0 TPL-binding domain in jasmonate signalling zf-C2H2_2 PF12756.7 CCF50057.1 - 0.25 11.7 1.1 0.57 10.5 0.0 2.0 1 1 0 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-C2H2 PF00096.26 CCF50057.1 - 0.25 11.9 0.4 0.5 10.9 0.4 1.5 1 0 0 1 1 1 0 Zinc finger, C2H2 type Atrophin-1 PF03154.15 CCF50057.1 - 2.9 6.1 16.8 4.1 5.6 16.8 1.2 1 0 0 1 1 1 0 Atrophin-1 family RR_TM4-6 PF06459.12 CCF50057.1 - 7 6.4 15.5 12 5.6 15.5 1.5 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Tubulin_3 PF14881.6 CCF50058.1 - 2e-28 99.3 0.1 6.3e-28 97.7 0.1 1.8 1 1 0 1 1 1 1 Tubulin domain Misat_Tub_SegII PF10644.9 CCF50058.1 - 5.7e-28 97.6 0.7 2e-27 95.9 0.7 1.9 1 1 0 1 1 1 1 Misato Segment II tubulin-like domain F-box-like PF12937.7 CCF50059.1 - 1.5e-06 28.0 0.6 0.042 13.7 0.0 2.7 2 0 0 2 2 2 2 F-box-like F-box PF00646.33 CCF50059.1 - 0.00027 20.7 4.5 0.14 12.1 0.4 2.4 2 0 0 2 2 2 2 F-box domain TPR_11 PF13414.6 CCF50059.1 - 0.012 15.3 0.0 0.028 14.1 0.0 1.6 1 0 0 1 1 1 0 TPR repeat TPR_14 PF13428.6 CCF50059.1 - 0.08 13.8 0.5 0.48 11.4 0.5 2.4 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_2 PF07719.17 CCF50059.1 - 0.13 12.5 0.1 0.43 10.8 0.1 2.0 1 0 0 1 1 1 0 Tetratricopeptide repeat Response_reg PF00072.24 CCF50061.1 - 7.8e-19 67.9 0.0 2e-18 66.6 0.0 1.8 1 0 0 1 1 1 1 Response regulator receiver domain HATPase_c PF02518.26 CCF50061.1 - 3.2e-14 53.4 0.0 5.9e-14 52.5 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 CCF50061.1 - 7.3e-06 25.9 0.7 2.3e-05 24.3 0.7 1.9 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain eIF3_subunit PF08597.10 CCF50062.1 - 5.3e-53 180.4 27.8 6e-53 180.2 27.8 1.0 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit S1FA PF04689.13 CCF50062.1 - 10 6.4 9.7 1.9 8.7 1.5 2.8 3 0 0 3 3 3 0 DNA binding protein S1FA zf-C2H2 PF00096.26 CCF50063.1 - 3.9e-07 30.2 19.4 0.00066 20.0 3.4 3.7 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 CCF50063.1 - 6.8e-07 29.4 17.4 0.00043 20.6 5.0 4.2 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 CCF50063.1 - 0.0029 18.3 16.3 0.058 14.3 1.4 3.7 3 0 0 3 3 3 2 C2H2-type zinc finger PASTA PF03793.19 CCF50064.1 - 0.095 12.6 0.4 0.18 11.7 0.4 1.4 1 0 0 1 1 1 0 PASTA domain tRNA_m1G_MT PF01746.21 CCF50065.1 - 3e-20 72.8 0.1 3.3e-15 56.3 0.1 3.0 2 1 0 2 2 2 2 tRNA (Guanine-1)-methyltransferase KptA_kDCL PF18176.1 CCF50065.1 - 0.37 10.6 2.3 33 4.3 0.0 3.0 3 0 0 3 3 3 0 KptA in kinetoplastid DICER domain Dcc1 PF09724.9 CCF50066.1 - 6.2e-78 262.4 0.0 7.5e-78 262.1 0.0 1.1 1 0 0 1 1 1 1 Sister chromatid cohesion protein Dcc1 bZIP_1 PF00170.21 CCF50068.1 - 7.8e-07 29.1 12.5 7.8e-07 29.1 12.5 1.9 2 0 0 2 2 2 1 bZIP transcription factor Ldh_1_N PF00056.23 CCF50069.1 - 5.3e-47 159.5 0.5 7.8e-47 158.9 0.5 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.18 CCF50069.1 - 2.2e-45 154.6 0.0 5.1e-45 153.4 0.0 1.6 2 0 0 2 2 2 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Glyco_hydro_4 PF02056.16 CCF50069.1 - 0.0029 17.2 0.1 0.26 10.8 0.0 2.3 1 1 1 2 2 2 2 Family 4 glycosyl hydrolase 3Beta_HSD PF01073.19 CCF50069.1 - 0.0037 16.3 0.0 0.0049 15.9 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family THF_DHG_CYH_C PF02882.19 CCF50069.1 - 0.035 13.4 1.5 0.46 9.8 0.3 2.7 2 1 0 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Linker_histone PF00538.19 CCF50070.1 - 0.13 12.6 0.0 0.36 11.2 0.0 1.8 1 0 0 1 1 1 0 linker histone H1 and H5 family Aldo_ket_red PF00248.21 CCF50071.1 - 9.4e-50 169.5 0.0 1.7e-47 162.1 0.0 2.1 1 1 0 1 1 1 1 Aldo/keto reductase family Na_Ca_ex PF01699.24 CCF50072.1 - 8e-46 155.7 42.1 4.2e-26 91.7 13.7 3.0 2 1 1 3 3 3 2 Sodium/calcium exchanger protein Complex1_49kDa PF00346.19 CCF50073.1 - 1.2e-121 404.9 0.0 1.6e-121 404.6 0.0 1.2 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 49 Kd subunit NiFeSe_Hases PF00374.19 CCF50073.1 - 0.0023 16.9 0.0 0.0041 16.1 0.0 1.4 1 0 0 1 1 1 1 Nickel-dependent hydrogenase Pkinase PF00069.25 CCF50074.1 - 4e-73 246.0 0.0 5.1e-73 245.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF50074.1 - 9.3e-35 120.1 0.0 1.5e-34 119.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCF50074.1 - 0.0014 18.1 0.0 0.0038 16.6 0.0 1.6 1 1 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 CCF50074.1 - 0.01 14.8 0.0 0.91 8.4 0.0 2.1 2 0 0 2 2 2 0 Haspin like kinase domain Kdo PF06293.14 CCF50074.1 - 0.052 12.9 0.8 0.15 11.4 0.8 1.7 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Asp PF00026.23 CCF50075.1 - 7.9e-107 357.3 0.2 9.5e-107 357.0 0.2 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 CCF50075.1 - 1.4e-13 51.4 1.5 1.6e-08 35.0 0.2 2.5 1 1 1 2 2 2 2 Xylanase inhibitor N-terminal TAXi_C PF14541.6 CCF50075.1 - 0.00025 20.8 0.0 0.0029 17.4 0.0 2.3 1 1 0 1 1 1 1 Xylanase inhibitor C-terminal Asp_protease_2 PF13650.6 CCF50075.1 - 0.00092 19.8 0.1 0.37 11.5 0.0 3.1 2 1 0 2 2 2 1 Aspartyl protease gag-asp_proteas PF13975.6 CCF50075.1 - 0.0077 16.8 0.0 2.2 8.9 0.0 2.6 2 0 0 2 2 2 1 gag-polyprotein putative aspartyl protease MscS_porin PF12795.7 CCF50076.1 - 0.038 13.5 0.7 0.054 13.0 0.7 1.2 1 0 0 1 1 1 0 Mechanosensitive ion channel porin domain Homeodomain PF00046.29 CCF50077.1 - 5.7e-19 67.7 4.9 1e-18 66.9 4.9 1.4 1 0 0 1 1 1 1 Homeodomain G6PD_C PF02781.16 CCF50078.1 - 1.4e-110 369.1 0.0 2.1e-110 368.5 0.0 1.2 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, C-terminal domain G6PD_N PF00479.22 CCF50078.1 - 1.7e-59 201.4 0.0 3.2e-59 200.5 0.0 1.5 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, NAD binding domain Rad4 PF03835.15 CCF50079.1 - 1.3e-27 96.3 0.2 1.3e-27 96.3 0.2 2.8 2 0 0 2 2 2 1 Rad4 transglutaminase-like domain BHD_3 PF10405.9 CCF50079.1 - 1e-26 93.1 0.1 1.8e-26 92.3 0.1 1.4 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 3 BHD_2 PF10404.9 CCF50079.1 - 1.8e-15 57.6 0.5 1.8e-15 57.6 0.5 5.4 6 0 0 6 6 6 1 Rad4 beta-hairpin domain 2 BHD_1 PF10403.9 CCF50079.1 - 2.3e-13 49.8 0.0 6.1e-13 48.4 0.0 1.8 2 0 0 2 2 2 1 Rad4 beta-hairpin domain 1 Transglut_core PF01841.19 CCF50079.1 - 5.5e-08 33.3 0.1 1.2e-05 25.8 0.0 3.1 2 0 0 2 2 2 1 Transglutaminase-like superfamily DivIC PF04977.15 CCF50079.1 - 0.067 13.0 1.4 0.32 10.8 1.4 2.2 1 0 0 1 1 1 0 Septum formation initiator DASH_Dad2 PF08654.10 CCF50079.1 - 0.25 11.8 4.1 1.2 9.6 4.1 2.2 1 0 0 1 1 1 0 DASH complex subunit Dad2 FAT PF02259.23 CCF50080.1 - 4.5e-68 230.0 7.4 4.5e-68 230.0 7.4 2.1 2 0 0 2 2 2 1 FAT domain PI3_PI4_kinase PF00454.27 CCF50080.1 - 3.8e-26 92.4 0.0 7.5e-26 91.4 0.0 1.6 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FATC PF02260.20 CCF50080.1 - 0.0031 17.3 0.1 0.0088 15.8 0.1 1.9 1 0 0 1 1 1 1 FATC domain DASH_Dad2 PF08654.10 CCF50080.1 - 0.085 13.3 0.1 2.2 8.7 0.0 3.2 1 1 0 2 2 2 0 DASH complex subunit Dad2 RasGEF_N_2 PF14663.6 CCF50080.1 - 0.29 11.6 6.2 1.9 8.9 0.2 4.6 4 0 0 4 4 4 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain SOG2 PF10428.9 CCF50080.1 - 1.3 8.1 62.3 0.05 12.8 8.1 4.7 5 0 0 5 5 5 0 RAM signalling pathway protein PI3_PI4_kinase PF00454.27 CCF50081.1 - 5e-33 115.0 0.0 1.5e-32 113.4 0.0 1.7 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 CCF50081.1 - 1.8e-05 24.2 0.6 4.3e-05 23.0 0.6 1.5 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) Pik1 PF11522.8 CCF50081.1 - 0.0044 16.9 0.1 0.014 15.3 0.1 1.9 1 0 0 1 1 1 1 Yeast phosphatidylinositol-4-OH kinase Pik1 DUF4135 PF13575.6 CCF50081.1 - 0.027 13.8 0.0 0.055 12.8 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4135) RRN3 PF05327.11 CCF50081.1 - 0.053 12.1 1.7 0.096 11.2 1.7 1.3 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 OCD_Mu_crystall PF02423.15 CCF50082.1 - 3e-18 65.9 0.0 3.2e-16 59.1 0.0 2.3 1 1 0 1 1 1 1 Ornithine cyclodeaminase/mu-crystallin family Dynactin_p22 PF07426.11 CCF50083.1 - 8.5e-12 45.2 2.6 8.5e-12 45.2 2.6 1.4 2 0 0 2 2 2 1 Dynactin subunit p22 DUF4363 PF14276.6 CCF50083.1 - 0.0012 18.9 2.6 0.3 11.2 0.2 3.1 2 1 1 3 3 3 1 Domain of unknown function (DUF4363) Snapin_Pallidin PF14712.6 CCF50083.1 - 0.013 15.9 7.3 0.3 11.5 2.9 2.6 2 1 1 3 3 3 0 Snapin/Pallidin Cluap1 PF10234.9 CCF50083.1 - 0.044 13.2 4.4 0.066 12.6 4.4 1.2 1 0 0 1 1 1 0 Clusterin-associated protein-1 NFRKB_winged PF14465.6 CCF50083.1 - 0.097 12.9 0.8 0.29 11.3 0.4 1.9 2 0 0 2 2 2 0 NFRKB Winged Helix-like PCRF PF03462.18 CCF50083.1 - 0.27 11.1 4.4 0.59 10.0 3.6 1.8 1 1 1 2 2 2 0 PCRF domain DivIC PF04977.15 CCF50083.1 - 3.1 7.6 7.0 2 8.2 2.7 2.3 2 0 0 2 2 2 0 Septum formation initiator Fib_alpha PF08702.10 CCF50083.1 - 4.4 7.5 8.1 33 4.6 7.9 2.6 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family ANAPC4_WD40 PF12894.7 CCF50084.1 - 5.2e-05 23.5 0.0 0.48 10.8 0.0 3.9 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 CCF50084.1 - 6.9e-05 23.5 1.3 0.22 12.5 0.0 4.8 5 0 0 5 5 5 1 WD domain, G-beta repeat Hira PF07569.11 CCF50084.1 - 0.024 14.4 0.1 0.43 10.3 0.0 2.4 3 0 0 3 3 3 0 TUP1-like enhancer of split Autophagy_act_C PF03987.15 CCF50085.1 - 5.4e-14 52.5 0.0 1.2e-13 51.4 0.0 1.6 1 0 0 1 1 1 1 Autophagocytosis associated protein, active-site domain WD40 PF00400.32 CCF50087.1 - 1.7e-25 88.8 13.0 2.2e-05 25.1 0.8 6.6 6 0 0 6 6 6 6 WD domain, G-beta repeat Nucleoporin_N PF08801.11 CCF50087.1 - 0.022 13.5 1.2 2.1 7.0 0.4 2.4 2 0 0 2 2 2 0 Nup133 N terminal like WD40_like PF17005.5 CCF50087.1 - 0.054 12.8 0.0 1.4 8.2 0.0 2.5 2 1 0 2 2 2 0 WD40-like domain CLTH PF10607.9 CCF50088.1 - 6.4e-23 81.3 0.0 3.5e-22 78.9 0.0 2.1 3 0 0 3 3 3 1 CTLH/CRA C-terminal to LisH motif domain LisH PF08513.11 CCF50088.1 - 0.0025 17.7 0.0 0.0048 16.8 0.0 1.5 1 0 0 1 1 1 1 LisH NIF PF03031.18 CCF50089.1 - 9.1e-12 45.0 0.0 2.2e-05 24.3 0.0 3.5 3 1 0 3 3 3 2 NLI interacting factor-like phosphatase SseC PF04888.12 CCF50090.1 - 0.022 14.4 1.5 0.092 12.3 0.0 2.0 2 0 0 2 2 2 0 Secretion system effector C (SseC) like family zf-RING_5 PF14634.6 CCF50091.1 - 0.0005 20.0 8.8 0.0005 20.0 8.8 2.1 2 1 0 2 2 2 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 CCF50091.1 - 0.00072 19.5 12.6 0.0017 18.3 12.6 1.8 1 1 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 CCF50091.1 - 0.0009 19.1 12.0 0.0009 19.1 12.0 2.6 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 CCF50091.1 - 0.0011 18.8 15.9 0.0018 18.1 9.7 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CCF50091.1 - 0.027 14.8 13.4 0.027 14.8 13.4 2.8 3 0 0 3 3 3 0 Ring finger domain zf-rbx1 PF12678.7 CCF50091.1 - 3.2 8.1 11.5 1.8 8.9 5.8 2.6 2 0 0 2 2 2 0 RING-H2 zinc finger domain Arginase PF00491.21 CCF50092.1 - 1.2e-78 264.4 0.0 1.5e-78 264.2 0.0 1.0 1 0 0 1 1 1 1 Arginase family DEAD PF00270.29 CCF50093.1 - 5.5e-37 127.2 0.1 1.2e-36 126.1 0.1 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CCF50093.1 - 1.5e-28 99.3 0.1 7.7e-26 90.6 0.1 2.8 3 1 0 3 3 3 2 Helicase conserved C-terminal domain ResIII PF04851.15 CCF50093.1 - 1.7e-08 34.7 0.0 3.3e-08 33.7 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CMS1 PF14617.6 CCF50093.1 - 0.0042 16.5 0.0 0.0086 15.4 0.0 1.5 1 0 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit Methyltransf_11 PF08241.12 CCF50094.1 - 8.7e-06 26.3 0.0 1.8e-05 25.3 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF50094.1 - 3.8e-05 23.5 0.0 5.4e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCF50094.1 - 4.8e-05 23.3 0.0 0.068 13.0 0.0 2.1 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_25 PF13649.6 CCF50094.1 - 0.00011 22.9 0.0 0.0011 19.6 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF50094.1 - 0.00047 20.8 0.0 0.00084 20.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CCF50094.1 - 0.14 11.5 0.0 0.19 11.0 0.0 1.5 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family Myc_N PF01056.18 CCF50095.1 - 0.029 14.3 0.3 0.029 14.3 0.3 7.5 4 2 2 7 7 7 0 Myc amino-terminal region Ribosomal_S26e PF01283.19 CCF50096.1 - 2.5e-54 182.3 5.5 2.9e-54 182.1 5.5 1.0 1 0 0 1 1 1 1 Ribosomal protein S26e PHD_2 PF13831.6 CCF50096.1 - 2.3 7.8 7.3 7.8 6.1 3.7 2.2 2 0 0 2 2 2 0 PHD-finger CPSF_A PF03178.15 CCF50097.1 - 1e-55 189.4 0.0 4.5e-55 187.2 0.0 2.1 1 1 0 1 1 1 1 CPSF A subunit region MMS1_N PF10433.9 CCF50097.1 - 5.2e-07 28.7 0.0 0.00033 19.4 0.0 2.7 2 1 0 2 2 2 2 Mono-functional DNA-alkylating methyl methanesulfonate N-term RR_TM4-6 PF06459.12 CCF50097.1 - 4 7.2 10.4 7.2 6.3 10.4 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 SPT16 PF08644.11 CCF50097.1 - 9.8 6.3 6.3 22 5.2 6.3 1.5 1 0 0 1 1 1 0 FACT complex subunit (SPT16/CDC68) WW PF00397.26 CCF50098.1 - 4.5e-09 36.2 1.2 1.1e-08 35.0 1.2 1.7 1 0 0 1 1 1 1 WW domain Alg14 PF08660.11 CCF50099.1 - 1.6e-48 164.9 0.0 2.5e-48 164.3 0.0 1.2 1 0 0 1 1 1 1 Oligosaccharide biosynthesis protein Alg14 like YvrJ PF12841.7 CCF50099.1 - 1.8 8.2 5.1 0.43 10.1 0.5 2.1 2 0 0 2 2 2 0 YvrJ protein family LON_substr_bdg PF02190.16 CCF50100.1 - 1.1e-20 74.4 0.0 6.6e-20 71.9 0.0 2.1 1 1 0 1 1 1 1 ATP-dependent protease La (LON) substrate-binding domain zf-C3HC4_2 PF13923.6 CCF50100.1 - 2.7e-18 65.5 21.5 7.8e-13 48.0 9.7 2.5 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 CCF50100.1 - 3e-12 46.2 16.0 2.7e-08 33.5 4.6 2.4 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CCF50100.1 - 5.2e-11 42.2 18.6 1.2e-05 25.1 7.7 2.6 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CCF50100.1 - 1.9e-10 40.9 19.6 2.8e-07 30.8 8.2 2.6 2 0 0 2 2 2 2 Ring finger domain zf-RING_UBOX PF13445.6 CCF50100.1 - 2.1e-10 40.4 25.0 2.6e-05 24.2 8.0 2.7 2 0 0 2 2 2 2 RING-type zinc-finger zf-RING_5 PF14634.6 CCF50100.1 - 1.3e-09 37.9 18.1 1.2e-05 25.2 7.3 2.5 2 0 0 2 2 2 2 zinc-RING finger domain zf-C3HC4_4 PF15227.6 CCF50100.1 - 2.5e-09 37.1 27.8 2.1e-06 27.8 4.1 3.0 3 0 0 3 3 3 2 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 CCF50100.1 - 2.9e-07 30.2 19.9 5.6e-06 26.1 6.1 2.5 2 0 0 2 2 2 2 Prokaryotic RING finger family 4 zf-RING_10 PF16685.5 CCF50100.1 - 5e-05 23.3 16.3 0.0002 21.4 3.5 2.5 2 0 0 2 2 2 2 zinc RING finger of MSL2 zf-rbx1 PF12678.7 CCF50100.1 - 0.003 17.8 13.0 0.024 14.9 5.4 2.9 2 0 0 2 2 2 2 RING-H2 zinc finger domain zf-RING_4 PF14570.6 CCF50100.1 - 0.0034 17.1 2.4 0.0034 17.1 2.4 2.5 2 0 0 2 2 2 1 RING/Ubox like zinc-binding domain zf-P11 PF03854.14 CCF50100.1 - 1.4 8.7 11.4 0.75 9.5 7.1 2.5 2 0 0 2 2 2 0 P-11 zinc finger Glutaredoxin PF00462.24 CCF50101.1 - 7.3e-16 58.1 0.0 1.1e-15 57.6 0.0 1.3 1 0 0 1 1 1 1 Glutaredoxin DUF836 PF05768.14 CCF50101.1 - 0.0041 17.5 0.1 0.005 17.2 0.1 1.3 1 0 0 1 1 1 1 Glutaredoxin-like domain (DUF836) Thioredoxin_2 PF13098.6 CCF50101.1 - 0.0058 17.1 0.1 0.0089 16.5 0.1 1.5 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_3 PF13192.6 CCF50101.1 - 0.076 13.1 0.0 0.19 11.8 0.0 1.6 1 1 0 1 1 1 0 Thioredoxin domain DSBA PF01323.20 CCF50101.1 - 0.14 11.9 0.2 0.23 11.2 0.1 1.5 1 1 0 1 1 1 0 DSBA-like thioredoxin domain DUF953 PF06110.11 CCF50101.1 - 0.14 11.8 0.0 0.16 11.6 0.0 1.5 1 1 0 1 1 1 0 Eukaryotic protein of unknown function (DUF953) GBP_C PF02841.14 CCF50103.1 - 0.12 11.8 0.0 0.25 10.7 0.0 1.4 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain Ribosomal_60s PF00428.19 CCF50103.1 - 0.35 11.5 5.1 12 6.5 2.0 2.9 2 0 0 2 2 2 0 60s Acidic ribosomal protein Pkinase PF00069.25 CCF50104.1 - 1e-67 228.3 0.0 1.3e-67 227.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF50104.1 - 1.5e-26 93.2 0.1 4.3e-26 91.8 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase Haspin_kinase PF12330.8 CCF50104.1 - 0.25 10.2 0.0 2.7 6.8 0.0 2.0 2 0 0 2 2 2 0 Haspin like kinase domain Slu7 PF11708.8 CCF50105.1 - 4.2e-89 298.9 19.8 4.2e-89 298.9 19.8 2.4 3 0 0 3 3 3 1 Pre-mRNA splicing Prp18-interacting factor zf-CCHC_4 PF14392.6 CCF50105.1 - 0.088 12.6 0.5 0.17 11.7 0.5 1.4 1 0 0 1 1 1 0 Zinc knuckle DDHD PF02862.17 CCF50105.1 - 4.7 7.3 10.4 6.4 6.9 1.1 2.4 2 0 0 2 2 2 0 DDHD domain RRM_1 PF00076.22 CCF50106.1 - 0.00042 20.1 0.0 0.012 15.4 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MAD PF05557.13 CCF50107.1 - 1.2e-41 142.9 47.9 2.3e-36 125.5 9.0 2.0 2 0 0 2 2 2 2 Mitotic checkpoint protein INCA1 PF15142.6 CCF50107.1 - 0.002 18.1 0.5 0.0064 16.5 0.5 1.9 1 0 0 1 1 1 1 INCA1 TMF_DNA_bd PF12329.8 CCF50107.1 - 0.0061 16.5 0.6 0.0061 16.5 0.6 8.9 8 3 1 9 9 9 2 TATA element modulatory factor 1 DNA binding bZIP_1 PF00170.21 CCF50107.1 - 0.099 12.8 0.3 0.099 12.8 0.3 8.7 7 2 3 10 10 10 0 bZIP transcription factor Shugoshin_N PF07558.11 CCF50107.1 - 0.73 9.8 4.3 15 5.5 0.1 4.2 4 0 0 4 4 4 0 Shugoshin N-terminal coiled-coil region ATG16 PF08614.11 CCF50107.1 - 2.6 8.2 75.8 0.086 13.1 6.1 6.3 3 2 3 6 6 6 0 Autophagy protein 16 (ATG16) FlaC_arch PF05377.11 CCF50107.1 - 5.1 7.6 12.8 87 3.6 0.1 6.5 5 2 1 6 6 6 0 Flagella accessory protein C (FlaC) Mito_fiss_reg PF05308.11 CCF50107.1 - 8.4 6.4 13.4 0.068 13.3 1.0 3.3 2 1 1 3 3 3 0 Mitochondrial fission regulator BTB_2 PF02214.22 CCF50108.1 - 0.00016 22.0 0.0 0.32 11.4 0.0 2.5 2 0 0 2 2 2 2 BTB/POZ domain Pkinase PF00069.25 CCF50109.1 - 4.7e-62 209.7 5.8 7.9e-43 146.7 0.0 3.1 3 0 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 CCF50109.1 - 2.6e-24 85.9 7.4 9.6e-20 70.9 0.0 3.0 3 0 0 3 3 2 2 Protein tyrosine kinase Haspin_kinase PF12330.8 CCF50109.1 - 7e-07 28.5 0.0 7e-07 28.5 0.0 2.1 2 0 0 2 2 1 1 Haspin like kinase domain Kdo PF06293.14 CCF50109.1 - 0.0024 17.3 0.0 0.015 14.6 0.0 2.3 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Presenilin PF01080.17 CCF50109.1 - 0.0033 16.2 15.1 0.0053 15.6 15.1 1.3 1 0 0 1 1 1 1 Presenilin Pkinase_fungal PF17667.1 CCF50109.1 - 0.085 11.6 0.0 0.085 11.6 0.0 2.4 2 1 0 2 2 1 0 Fungal protein kinase APH PF01636.23 CCF50109.1 - 0.099 12.5 0.1 0.099 12.5 0.1 3.8 2 2 1 3 3 2 0 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.11 CCF50109.1 - 0.15 11.0 0.0 0.27 10.1 0.0 1.3 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Seadorna_VP7 PF07387.11 CCF50109.1 - 0.19 10.8 0.0 0.32 10.0 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 eIF-3_zeta PF05091.12 CCF50109.1 - 0.71 8.8 18.8 1.5 7.8 18.8 1.5 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) SPX PF03105.19 CCF50109.1 - 9.4 6.0 22.7 15 5.3 22.7 1.3 1 0 0 1 1 1 0 SPX domain GMC_oxred_N PF00732.19 CCF50110.1 - 5.3e-65 219.7 0.0 8.1e-65 219.1 0.0 1.3 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 CCF50110.1 - 2.8e-34 118.7 0.0 5.1e-34 117.9 0.0 1.4 1 0 0 1 1 1 1 GMC oxidoreductase FAD_binding_2 PF00890.24 CCF50110.1 - 1.3e-05 24.5 0.7 0.016 14.3 0.3 2.2 2 0 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.6 CCF50110.1 - 5.2e-05 23.4 0.1 0.00016 21.8 0.1 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 CCF50110.1 - 0.00011 21.4 0.0 0.00018 20.7 0.0 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein DAO PF01266.24 CCF50110.1 - 0.0017 18.0 0.1 0.011 15.3 0.1 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CCF50110.1 - 0.021 14.0 0.1 0.12 11.6 0.1 1.9 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CCF50110.1 - 0.033 12.9 0.1 0.69 8.6 0.0 2.1 2 0 0 2 2 2 0 HI0933-like protein NAD_binding_9 PF13454.6 CCF50110.1 - 0.035 14.1 0.5 0.066 13.2 0.1 1.7 2 0 0 2 2 2 0 FAD-NAD(P)-binding Thi4 PF01946.17 CCF50110.1 - 0.038 13.2 0.2 0.075 12.3 0.2 1.4 1 0 0 1 1 1 0 Thi4 family FAD_binding_3 PF01494.19 CCF50110.1 - 0.084 12.1 0.8 0.13 11.5 0.1 1.6 2 0 0 2 2 2 0 FAD binding domain Pyr_redox_3 PF13738.6 CCF50110.1 - 0.091 12.0 0.3 3.2 6.9 0.2 2.4 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase ChAPs PF09295.10 CCF50111.1 - 1.4e-154 514.9 0.0 2.4e-154 514.1 0.0 1.4 1 0 0 1 1 1 1 ChAPs (Chs5p-Arf1p-binding proteins) TPR_19 PF14559.6 CCF50111.1 - 1.3e-05 25.7 1.8 0.0074 16.8 0.3 3.5 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 CCF50111.1 - 0.00083 19.3 4.4 2.7 8.3 0.1 5.4 6 0 0 6 6 6 1 Tetratricopeptide repeat ANAPC3 PF12895.7 CCF50111.1 - 0.017 15.3 9.1 0.026 14.7 2.3 4.1 4 1 0 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 CCF50111.1 - 0.035 14.7 0.5 1.7e+02 3.1 0.0 4.7 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_8 PF13181.6 CCF50111.1 - 0.22 11.8 2.2 63 4.2 0.0 4.7 5 0 0 5 5 5 0 Tetratricopeptide repeat Ribosom_S12_S23 PF00164.25 CCF50112.1 - 5.4e-36 122.7 1.2 7e-36 122.3 1.2 1.1 1 0 0 1 1 1 1 Ribosomal protein S12/S23 PH_4 PF15404.6 CCF50113.1 - 3e-52 177.1 0.0 1.2e-51 175.1 0.0 2.2 1 0 0 1 1 1 1 Pleckstrin homology domain PH_13 PF16652.5 CCF50113.1 - 0.61 9.9 1.7 3 7.6 0.2 2.6 3 0 0 3 3 3 0 Pleckstrin homology domain Mobilization_B PF17511.2 CCF50113.1 - 0.72 10.2 10.2 7.3 7.0 0.1 3.7 3 0 0 3 3 3 0 Mobilization protein B IPK PF03770.16 CCF50114.1 - 2.6e-40 138.4 0.0 4.2e-39 134.4 0.0 2.1 1 1 0 1 1 1 1 Inositol polyphosphate kinase TPR_1 PF00515.28 CCF50115.1 - 0.00029 20.5 1.0 0.0051 16.6 0.0 2.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 CCF50115.1 - 0.0015 19.1 2.7 0.028 15.1 1.1 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 CCF50115.1 - 0.0017 18.3 2.2 0.032 14.3 0.1 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_9 PF13371.6 CCF50115.1 - 0.003 17.7 0.8 0.01 16.0 0.3 2.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 CCF50115.1 - 0.0032 18.1 1.1 0.032 15.0 0.5 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.6 CCF50115.1 - 0.018 15.4 0.4 4.6 7.8 0.1 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.6 CCF50115.1 - 0.028 14.4 0.3 0.21 11.7 0.1 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat bVLRF1 PF18826.1 CCF50116.1 - 8.3e-50 168.5 0.0 1.9e-49 167.4 0.0 1.7 1 0 0 1 1 1 1 bacteroidetes VLRF1 release factor SRP14 PF02290.15 CCF50117.1 - 6.1e-19 68.2 4.8 8.1e-19 67.8 0.0 2.2 1 1 1 2 2 2 1 Signal recognition particle 14kD protein DUF726 PF05277.12 CCF50118.1 - 4.6e-116 387.5 2.6 6.3e-116 387.1 2.6 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF726) Abhydrolase_1 PF00561.20 CCF50118.1 - 0.0013 18.5 0.7 0.17 11.5 0.0 2.6 2 0 0 2 2 2 2 alpha/beta hydrolase fold TMEM252 PF15664.5 CCF50118.1 - 0.11 12.3 0.9 0.33 10.7 0.9 1.8 1 0 0 1 1 1 0 Transmembrane protein 252 family Transketolase_N PF00456.21 CCF50119.1 - 3.3e-154 512.8 0.1 4.5e-154 512.4 0.1 1.2 1 0 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain Transket_pyr PF02779.24 CCF50119.1 - 7.2e-41 139.8 0.1 1.7e-40 138.6 0.0 1.6 2 0 0 2 2 2 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 CCF50119.1 - 1.7e-14 53.8 0.0 3.9e-14 52.6 0.0 1.7 1 0 0 1 1 1 1 Transketolase, C-terminal domain DXP_synthase_N PF13292.6 CCF50119.1 - 0.042 13.0 0.1 0.18 11.0 0.1 1.8 1 1 1 2 2 2 0 1-deoxy-D-xylulose-5-phosphate synthase UspB PF10625.9 CCF50121.1 - 0.085 12.8 0.0 0.19 11.7 0.0 1.6 1 0 0 1 1 1 0 Universal stress protein B (UspB) RT_RNaseH PF17917.1 CCF50125.1 - 3e-06 27.4 0.2 1.6e-05 25.1 0.0 2.1 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 CCF50125.1 - 2.9e-05 24.0 0.0 9.7e-05 22.3 0.0 1.9 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 CCF50125.1 - 0.0084 15.7 0.2 0.021 14.3 0.2 1.7 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Zn_clus PF00172.18 CCF50126.1 - 0.0082 16.3 9.5 0.023 14.8 9.5 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain LigB PF02900.18 CCF50127.1 - 1.8e-21 76.4 0.2 2.4e-20 72.7 0.2 1.9 1 1 0 1 1 1 1 Catalytic LigB subunit of aromatic ring-opening dioxygenase CoA_binding_2 PF13380.6 CCF50127.1 - 0.058 13.9 0.0 0.15 12.6 0.0 1.6 1 0 0 1 1 1 0 CoA binding domain ABC1 PF03109.16 CCF50128.1 - 4.4e-32 110.7 0.0 8.9e-32 109.8 0.0 1.5 1 0 0 1 1 1 1 ABC1 family RIO1 PF01163.22 CCF50128.1 - 0.0093 15.6 0.0 0.027 14.1 0.0 1.8 1 1 0 1 1 1 1 RIO1 family Pkinase PF00069.25 CCF50128.1 - 0.16 11.3 0.0 15 4.9 0.0 2.3 2 0 0 2 2 2 0 Protein kinase domain MFS_1 PF07690.16 CCF50129.1 - 1.4e-45 155.8 23.4 1.4e-45 155.8 23.4 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF50129.1 - 1.1e-14 54.2 17.3 1.3e-13 50.7 17.1 2.1 1 1 0 1 1 1 1 Sugar (and other) transporter TED_complement PF07678.14 CCF50129.1 - 0.14 11.1 0.8 0.24 10.4 0.8 1.3 1 0 0 1 1 1 0 A-macroglobulin TED domain DUF5421 PF17458.2 CCF50129.1 - 0.26 10.7 3.6 0.38 10.1 3.6 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5421) OATP PF03137.20 CCF50129.1 - 0.27 9.5 8.0 0.012 13.9 0.5 2.4 2 1 0 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family SdpI PF13630.6 CCF50129.1 - 0.33 11.1 0.1 0.33 11.1 0.1 3.5 4 1 0 4 4 4 0 SdpI/YhfL protein family FAD_binding_2 PF00890.24 CCF50130.1 - 4e-87 293.0 0.2 5.6e-87 292.5 0.2 1.2 1 0 0 1 1 1 1 FAD binding domain Cyt-b5 PF00173.28 CCF50130.1 - 1.8e-20 72.8 0.3 7.3e-20 70.9 0.1 2.1 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain DAO PF01266.24 CCF50130.1 - 6.1e-15 55.7 0.3 1.6e-14 54.3 0.3 1.6 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CCF50130.1 - 1.2e-10 41.4 0.2 1.1e-09 38.3 0.1 2.6 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.7 CCF50130.1 - 2.2e-09 37.2 0.4 6.3e-09 35.7 0.4 1.8 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CCF50130.1 - 2.5e-09 36.8 0.2 2.4e-06 27.0 0.1 2.7 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CCF50130.1 - 4.9e-07 28.8 3.0 0.00013 20.9 0.1 3.1 3 0 0 3 3 3 1 HI0933-like protein GIDA PF01134.22 CCF50130.1 - 1.5e-06 27.6 1.9 0.0037 16.4 0.3 3.2 4 0 0 4 4 4 2 Glucose inhibited division protein A Pyr_redox_3 PF13738.6 CCF50130.1 - 2.4e-06 27.0 0.1 0.0095 15.2 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 CCF50130.1 - 2.7e-06 26.8 0.4 0.0046 16.2 0.1 2.5 2 0 0 2 2 2 2 Thi4 family FAD_binding_3 PF01494.19 CCF50130.1 - 2.9e-06 26.8 1.7 1e-05 25.0 1.7 1.9 1 1 0 1 1 1 1 FAD binding domain Amino_oxidase PF01593.24 CCF50130.1 - 0.00033 20.1 0.2 0.0017 17.7 0.0 2.2 3 0 0 3 3 3 1 Flavin containing amine oxidoreductase AlaDh_PNT_C PF01262.21 CCF50130.1 - 0.0004 19.7 2.0 0.0008 18.8 0.2 2.1 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox PF00070.27 CCF50130.1 - 0.00048 20.6 0.6 0.013 16.0 0.1 2.8 3 0 0 3 3 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CCF50130.1 - 0.04 13.9 0.0 0.83 9.6 0.0 2.6 2 0 0 2 2 2 0 FAD-NAD(P)-binding NAD_binding_7 PF13241.6 CCF50130.1 - 0.056 13.9 0.0 0.15 12.5 0.0 1.8 1 0 0 1 1 1 0 Putative NAD(P)-binding GDI PF00996.18 CCF50130.1 - 0.07 11.6 0.0 0.12 10.8 0.0 1.3 1 0 0 1 1 1 0 GDP dissociation inhibitor Lycopene_cycl PF05834.12 CCF50130.1 - 0.084 11.9 0.1 0.19 10.7 0.0 1.6 2 0 0 2 2 2 0 Lycopene cyclase protein TrkA_N PF02254.18 CCF50130.1 - 0.16 12.3 0.1 0.57 10.4 0.0 2.0 2 0 0 2 2 1 0 TrkA-N domain Nfu_N PF08712.11 CCF50131.1 - 3.4e-32 110.3 0.0 8.6e-32 109.0 0.0 1.7 2 0 0 2 2 2 1 Scaffold protein Nfu/NifU N terminal NifU PF01106.17 CCF50131.1 - 6.4e-27 93.5 0.1 1.1e-26 92.7 0.1 1.4 1 0 0 1 1 1 1 NifU-like domain YojJ PF10372.9 CCF50131.1 - 0.093 12.8 0.1 0.19 11.8 0.1 1.5 1 0 0 1 1 1 0 Bacterial membrane-spanning protein N-terminus ECH_1 PF00378.20 CCF50132.1 - 1.6e-84 283.1 1.4 1.9e-84 282.9 1.4 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 CCF50132.1 - 1.2e-34 120.3 1.4 4.5e-32 111.9 0.1 2.0 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase Peptidase_S49 PF01343.18 CCF50132.1 - 0.0044 17.0 0.1 0.12 12.3 0.0 2.5 2 1 0 2 2 2 1 Peptidase family S49 RVT_2 PF07727.14 CCF50134.1 - 1.3e-14 54.4 0.0 1.7e-14 54.1 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Orbi_VP5 PF00901.17 CCF50134.1 - 0.0033 15.9 0.2 0.0041 15.6 0.2 1.1 1 0 0 1 1 1 1 Orbivirus outer capsid protein VP5 Orthopox_B11R PF07033.11 CCF50134.1 - 0.097 12.5 0.0 0.16 11.8 0.0 1.3 1 0 0 1 1 1 0 Orthopoxvirus B11R protein Rep_4 PF05797.11 CCF50136.1 - 0.11 11.7 0.0 0.18 10.9 0.0 1.5 1 1 1 2 2 2 0 Yeast trans-acting factor (REP1/REP2) GCP_C_terminal PF04130.13 CCF50137.1 - 3.5e-40 138.4 0.0 8.4e-40 137.1 0.0 1.7 1 0 0 1 1 1 1 Gamma tubulin complex component C-terminal GCP_N_terminal PF17681.1 CCF50137.1 - 3.7e-13 49.8 0.0 1.2e-12 48.1 0.0 1.9 2 1 0 2 2 2 1 Gamma tubulin complex component N-terminal DUF4955 PF16315.5 CCF50137.1 - 0.052 13.7 0.1 0.11 12.7 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4955) Stn1_C PF12659.7 CCF50137.1 - 0.097 12.6 0.2 0.23 11.4 0.2 1.5 1 0 0 1 1 1 0 Telomere capping C-terminal wHTH DNA_pol_E_B PF04042.16 CCF50138.1 - 2.5e-41 141.4 0.0 3.6e-41 140.9 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B DNA_pol_D_N PF18018.1 CCF50138.1 - 1.5e-37 128.6 0.0 2.3e-37 128.0 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase delta subunit OB-fold domain DUF3760 PF12586.8 CCF50139.1 - 0.047 13.9 0.5 0.33 11.2 1.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3760) DUF572 PF04502.13 CCF50140.1 - 2e-75 254.5 9.1 9.3e-75 252.3 9.1 1.8 1 1 0 1 1 1 1 Family of unknown function (DUF572) MARVEL PF01284.23 CCF50141.1 - 0.0025 17.9 7.9 0.0036 17.3 7.3 1.6 1 1 0 1 1 1 1 Membrane-associating domain DUF2583 PF10762.9 CCF50141.1 - 0.071 13.5 0.2 0.17 12.4 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2583) CRAL_TRIO PF00650.20 CCF50142.1 - 1.7e-40 138.4 0.0 3.1e-40 137.5 0.0 1.4 1 0 0 1 1 1 1 CRAL/TRIO domain Hydrolase_6 PF13344.6 CCF50142.1 - 4e-28 97.5 0.0 7.9e-28 96.5 0.0 1.5 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 CCF50142.1 - 6.4e-19 67.8 0.0 1.7e-18 66.5 0.0 1.8 1 0 0 1 1 1 1 HAD-hyrolase-like CRAL_TRIO_2 PF13716.6 CCF50142.1 - 1e-10 41.9 0.0 1.8e-10 41.1 0.0 1.5 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain Hydrolase PF00702.26 CCF50142.1 - 1.4e-08 35.3 0.0 2.8e-08 34.3 0.0 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 CCF50142.1 - 2.9e-06 27.5 0.0 0.00059 20.0 0.0 2.5 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase CRAL_TRIO_N PF03765.15 CCF50142.1 - 3.5e-05 23.9 0.1 0.00011 22.3 0.1 1.9 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain Peripla_BP_4 PF13407.6 CCF50142.1 - 0.0093 15.6 0.0 0.023 14.3 0.0 1.7 1 1 0 1 1 1 1 Periplasmic binding protein domain PGP_phosphatase PF09419.10 CCF50142.1 - 0.048 13.3 0.0 0.095 12.3 0.0 1.4 1 0 0 1 1 1 0 Mitochondrial PGP phosphatase DFF40 PF09230.10 CCF50143.1 - 0.18 11.4 0.0 0.24 11.0 0.0 1.1 1 0 0 1 1 1 0 DNA fragmentation factor 40 kDa CMD PF02627.20 CCF50144.1 - 3.1e-08 33.6 0.1 5.3e-08 32.8 0.1 1.3 1 0 0 1 1 1 1 Carboxymuconolactone decarboxylase family Mito_carr PF00153.27 CCF50145.1 - 1.5e-53 178.7 4.8 1.3e-19 69.9 0.0 4.2 4 0 0 4 4 4 4 Mitochondrial carrier protein PGM_PMM_I PF02878.16 CCF50146.1 - 4.8e-18 65.2 0.1 1.9e-08 34.1 0.0 2.9 1 1 2 3 3 3 2 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_IV PF00408.20 CCF50146.1 - 4.2e-09 36.4 0.0 9.7e-09 35.3 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain PGM_PMM_II PF02879.16 CCF50146.1 - 0.0029 18.2 0.1 0.017 15.7 0.1 2.4 1 1 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_III PF02880.16 CCF50146.1 - 0.033 14.4 0.0 0.059 13.6 0.0 1.5 1 0 0 1 1 1 0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III ORMDL PF04061.14 CCF50147.1 - 1e-55 187.3 1.6 1.2e-55 187.0 1.6 1.1 1 0 0 1 1 1 1 ORMDL family RIBIOP_C PF04950.12 CCF50148.1 - 2.7e-111 371.7 0.0 5e-111 370.8 0.0 1.4 1 0 0 1 1 1 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal AARP2CN PF08142.12 CCF50148.1 - 1.1e-21 76.7 0.0 2.3e-21 75.7 0.0 1.6 1 0 0 1 1 1 1 AARP2CN (NUC121) domain eIF_4EBP PF05456.11 CCF50149.1 - 3.1e-06 27.1 0.4 3.8e-06 26.8 0.4 1.3 1 1 0 1 1 1 1 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) Mito_carr PF00153.27 CCF50150.1 - 1.8e-62 207.3 1.3 3.8e-24 84.4 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 CCF50150.1 - 0.13 11.4 0.2 11 5.1 0.0 2.8 2 1 1 3 3 3 0 Gammaproteobacterial serine protease Rad52_Rad22 PF04098.15 CCF50151.1 - 1.9e-56 190.3 0.1 1.4e-55 187.4 0.0 2.4 3 0 0 3 3 3 1 Rad52/22 family double-strand break repair protein GREB1 PF15782.5 CCF50151.1 - 1.3 6.1 6.6 1.7 5.7 6.6 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Trehalase PF01204.18 CCF50151.1 - 1.6 7.4 5.0 0.17 10.7 0.3 1.7 2 0 0 2 2 2 0 Trehalase Pkinase PF00069.25 CCF50152.1 - 3.6e-68 229.8 0.0 6.3e-68 229.0 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF50152.1 - 6.4e-38 130.5 0.0 1.7e-37 129.1 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase KA1 PF02149.19 CCF50152.1 - 3.1e-09 36.5 0.1 5.5e-09 35.7 0.1 1.4 1 0 0 1 1 1 1 Kinase associated domain 1 Kinase-like PF14531.6 CCF50152.1 - 9.4e-09 35.0 0.0 1.6e-08 34.2 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 CCF50152.1 - 0.005 15.8 0.1 0.011 14.7 0.1 1.5 1 0 0 1 1 1 1 Haspin like kinase domain RIO1 PF01163.22 CCF50152.1 - 0.015 14.9 0.4 0.037 13.6 0.4 1.6 1 0 0 1 1 1 0 RIO1 family APH PF01636.23 CCF50152.1 - 0.019 14.9 0.1 0.062 13.2 0.1 1.9 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF1687 PF07955.11 CCF50153.1 - 1.6e-12 48.0 2.5 4.9e-12 46.4 2.5 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF1687) F-box PF00646.33 CCF50154.1 - 2.7e-08 33.5 0.9 7e-08 32.2 0.9 1.7 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 CCF50154.1 - 2.5e-05 24.1 0.3 7.5e-05 22.5 0.3 1.9 1 0 0 1 1 1 1 F-box-like MNSV_P7B PF06692.11 CCF50154.1 - 0.029 14.4 0.0 0.074 13.1 0.0 1.7 1 0 0 1 1 1 0 Melon necrotic spot virus P7B protein DDOST_48kD PF03345.14 CCF50155.1 - 2e-114 382.6 0.3 2.3e-70 237.5 0.1 2.1 2 0 0 2 2 2 2 Oligosaccharyltransferase 48 kDa subunit beta Gly_radical PF01228.21 CCF50155.1 - 0.0071 16.9 0.0 0.022 15.3 0.0 1.8 1 0 0 1 1 1 1 Glycine radical ABC_transp_aux PF09822.9 CCF50155.1 - 0.06 12.8 0.0 0.099 12.1 0.0 1.3 1 0 0 1 1 1 0 ABC-type uncharacterized transport system DUF1647 PF07801.11 CCF50155.1 - 0.09 12.5 0.0 0.31 10.8 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1647) DUF2194 PF09960.9 CCF50155.1 - 0.11 10.8 0.0 0.16 10.3 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein conserved in bacteria (DUF2194) Nkap_C PF06047.11 CCF50156.1 - 3.3e-48 162.0 2.1 3.3e-48 162.0 2.1 1.9 2 0 0 2 2 2 1 NF-kappa-B-activating protein C-terminal domain Diphthami_syn_2 PF01902.17 CCF50157.1 - 4.6e-34 117.8 0.0 8.2e-25 87.6 0.0 2.2 2 0 0 2 2 2 2 Diphthamide synthase Ribonuc_L-PSP PF01042.21 CCF50157.1 - 2.6e-15 56.5 0.0 1.6e-08 34.6 0.0 2.5 2 0 0 2 2 2 2 Endoribonuclease L-PSP tRNA_Me_trans PF03054.16 CCF50157.1 - 0.16 10.8 0.0 0.23 10.2 0.0 1.2 1 0 0 1 1 1 0 tRNA methyl transferase SUV3_C PF12513.8 CCF50158.1 - 3e-16 59.1 0.4 6.6e-16 58.0 0.4 1.6 1 0 0 1 1 1 1 Mitochondrial degradasome RNA helicase subunit C terminal Helicase_C PF00271.31 CCF50158.1 - 1.4e-11 44.7 0.0 2.9e-11 43.7 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Suv3_C_1 PF18147.1 CCF50158.1 - 2.7e-06 27.1 0.1 5.6e-06 26.1 0.1 1.6 1 0 0 1 1 1 1 Suv3 C-terminal domain 1 LrgB PF04172.16 CCF50159.1 - 1.8e-29 102.8 16.8 1.8e-29 102.8 16.8 3.3 3 1 0 3 3 3 1 LrgB-like family LrgA PF03788.14 CCF50159.1 - 0.00065 19.6 3.4 0.00065 19.6 3.4 3.3 3 0 0 3 3 3 1 LrgA family DUF4746 PF15928.5 CCF50159.1 - 0.37 10.2 1.0 0.65 9.4 1.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) FAM70 PF14967.6 CCF50159.1 - 0.51 9.7 3.7 0.18 11.2 0.2 2.0 2 0 0 2 2 2 0 FAM70 protein Presenilin PF01080.17 CCF50159.1 - 1.9 7.2 8.1 0.071 11.9 0.3 2.6 3 0 0 3 3 3 0 Presenilin Zn_clus PF00172.18 CCF50160.1 - 0.018 15.1 10.7 0.042 14.0 10.7 1.6 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain LCM PF04072.14 CCF50161.1 - 4.4e-14 52.8 0.0 2.6e-13 50.4 0.0 2.0 1 1 0 1 1 1 1 Leucine carboxyl methyltransferase Glyco_transf_11 PF01531.16 CCF50162.1 - 0.16 11.2 0.0 0.28 10.3 0.0 1.3 1 0 0 1 1 1 0 Glycosyl transferase family 11 Hydrophobin PF01185.18 CCF50163.1 - 2.4e-16 60.1 12.1 3.1e-16 59.8 12.1 1.1 1 0 0 1 1 1 1 Fungal hydrophobin MF_alpha_N PF05436.11 CCF50163.1 - 0.15 11.9 0.1 0.36 10.8 0.1 1.6 2 0 0 2 2 2 0 Mating factor alpha precursor N-terminus Toxin_12 PF07740.12 CCF50163.1 - 1.6 9.5 7.8 2.4 8.9 0.7 2.5 2 0 0 2 2 2 0 Ion channel inhibitory toxin Ribosomal_L28e PF01778.17 CCF50164.1 - 1.3e-32 112.9 0.6 1.6e-32 112.7 0.6 1.1 1 0 0 1 1 1 1 Ribosomal L28e protein family CelD_N PF02927.14 CCF50164.1 - 0.13 13.2 1.2 13 6.8 0.1 2.4 1 1 2 3 3 3 0 Cellulase N-terminal ig-like domain F-box-like PF12937.7 CCF50165.1 - 1.5e-08 34.4 0.1 3.3e-08 33.3 0.1 1.6 1 0 0 1 1 1 1 F-box-like WD40 PF00400.32 CCF50165.1 - 1.6e-06 28.7 0.1 0.71 10.9 0.1 4.1 3 1 0 3 3 3 2 WD domain, G-beta repeat F-box PF00646.33 CCF50165.1 - 0.00038 20.3 0.0 0.00081 19.2 0.0 1.5 1 0 0 1 1 1 1 F-box domain UIM PF02809.20 CCF50165.1 - 1.3 9.1 14.5 0.18 11.8 0.2 3.3 3 0 0 3 3 3 0 Ubiquitin interaction motif MarR_2 PF12802.7 CCF50166.1 - 4.3e-05 23.3 0.0 0.00022 21.0 0.0 2.3 1 0 0 1 1 1 1 MarR family B-block_TFIIIC PF04182.12 CCF50166.1 - 9.8e-05 22.4 0.0 0.00028 21.0 0.0 1.8 2 0 0 2 2 2 1 B-block binding subunit of TFIIIC HTH_micro PF17007.5 CCF50166.1 - 0.00061 18.7 0.0 0.00098 18.0 0.0 1.2 1 0 0 1 1 1 1 HTH-like MarR PF01047.22 CCF50166.1 - 0.004 17.0 0.1 0.025 14.5 0.0 2.5 3 0 0 3 3 3 1 MarR family Ribosomal_S17 PF00366.20 CCF50167.1 - 1.8e-22 79.2 0.1 3e-22 78.5 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein S17 Scs3p PF10261.9 CCF50169.1 - 2.6e-61 207.3 0.0 1.2e-60 205.1 0.0 1.9 1 1 0 1 1 1 1 Inositol phospholipid synthesis and fat-storage-inducing TM ApoO PF09769.9 CCF50170.1 - 3.1e-28 98.3 0.6 5.3e-27 94.3 0.0 2.1 1 1 1 2 2 2 1 Apolipoprotein O PhaP_Bmeg PF09602.10 CCF50170.1 - 0.017 15.0 1.2 0.028 14.4 1.2 1.2 1 0 0 1 1 1 0 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) Tox-REase-9 PF15650.6 CCF50170.1 - 0.068 13.5 0.2 0.15 12.3 0.2 1.6 1 1 0 1 1 1 0 Restriction endonuclease fold toxin 9 bZIP_1 PF00170.21 CCF50171.1 - 0.0013 18.8 6.6 0.44 10.7 0.6 2.6 2 0 0 2 2 2 2 bZIP transcription factor DUF4470 PF14737.6 CCF50171.1 - 0.14 12.3 0.0 0.38 10.9 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4470) DUF5094 PF17015.5 CCF50171.1 - 0.45 10.6 1.2 16 5.6 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF5094) bZIP_2 PF07716.15 CCF50171.1 - 0.5 10.5 7.4 5.8 7.1 0.7 2.6 2 0 0 2 2 2 0 Basic region leucine zipper DegS PF05384.11 CCF50171.1 - 0.57 9.7 5.3 3.4 7.1 0.8 2.4 2 0 0 2 2 2 0 Sensor protein DegS Rootletin PF15035.6 CCF50171.1 - 0.78 9.7 7.8 0.11 12.4 2.9 2.0 2 0 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion RasGAP_C PF03836.15 CCF50171.1 - 0.86 9.7 3.7 0.4 10.8 0.6 2.0 2 0 0 2 2 2 0 RasGAP C-terminus FlaC_arch PF05377.11 CCF50171.1 - 1.9 8.9 7.2 5.2 7.5 0.2 3.2 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) NYD-SP28_assoc PF14775.6 CCF50171.1 - 2 8.6 6.8 11 6.2 0.5 2.5 2 0 0 2 2 2 0 Sperm tail C-terminal domain Cep57_CLD_2 PF14197.6 CCF50171.1 - 2.5 8.2 10.6 1.7 8.8 3.8 2.5 2 0 0 2 2 2 0 Centrosome localisation domain of PPC89 UPF0242 PF06785.11 CCF50171.1 - 2.5 8.1 9.3 1.5 8.9 3.3 2.2 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus HALZ PF02183.18 CCF50171.1 - 2.7 8.3 8.2 5.7 7.2 0.9 2.8 2 0 0 2 2 2 0 Homeobox associated leucine zipper Cnn_1N PF07989.11 CCF50171.1 - 2.9 8.1 7.4 0.57 10.4 2.0 2.2 2 0 0 2 2 2 0 Centrosomin N-terminal motif 1 Uso1_p115_C PF04871.13 CCF50171.1 - 3.4 8.1 10.4 3.8 7.9 5.0 2.7 2 0 0 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region EMC3_TMCO1 PF01956.16 CCF50172.1 - 2.8 7.7 6.3 6 6.6 6.3 1.5 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like Tho2 PF11262.8 CCF50172.1 - 4 6.6 10.1 0.26 10.5 4.7 1.7 2 0 0 2 2 2 0 Transcription factor/nuclear export subunit protein 2 PAP_assoc PF03828.19 CCF50173.1 - 1.6e-13 50.7 0.1 3.2e-13 49.6 0.1 1.6 1 0 0 1 1 1 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.23 CCF50173.1 - 2.5e-06 27.7 0.0 4.7e-06 26.8 0.0 1.4 1 0 0 1 1 1 1 Nucleotidyltransferase domain Polbeta PF18765.1 CCF50173.1 - 0.014 15.4 0.0 0.029 14.4 0.0 1.4 1 0 0 1 1 1 0 Polymerase beta, Nucleotidyltransferase RVT_2 PF07727.14 CCF50174.1 - 0.085 12.5 0.0 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) Pkinase PF00069.25 CCF50175.1 - 2.2e-52 178.0 0.0 3.1e-52 177.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF50175.1 - 1.9e-36 125.7 0.0 2.9e-36 125.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CCF50175.1 - 5e-09 35.4 0.0 1.4e-08 34.0 0.0 1.8 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 CCF50175.1 - 0.0049 16.2 0.0 0.031 13.6 0.0 2.0 2 0 0 2 2 2 1 Kinase-like PBD PF00786.28 CCF50175.1 - 0.0074 16.6 0.1 0.019 15.3 0.1 1.7 1 0 0 1 1 1 1 P21-Rho-binding domain APH PF01636.23 CCF50175.1 - 0.025 14.5 0.0 0.067 13.1 0.0 1.7 1 0 0 1 1 1 0 Phosphotransferase enzyme family UBA_4 PF14555.6 CCF50178.1 - 8.1e-11 41.6 0.4 2.7e-10 39.9 0.0 2.1 2 0 0 2 2 2 1 UBA-like domain UIM PF02809.20 CCF50178.1 - 2e-06 27.3 9.9 0.0028 17.5 1.7 3.0 2 0 0 2 2 2 2 Ubiquitin interaction motif TAP_C PF03943.13 CCF50178.1 - 0.0005 19.7 0.0 0.0013 18.3 0.0 1.7 1 0 0 1 1 1 1 TAP C-terminal domain FRG1 PF06229.12 CCF50178.1 - 0.033 13.9 0.0 0.076 12.7 0.0 1.5 1 0 0 1 1 1 0 FRG1-like domain S4 PF01479.25 CCF50179.1 - 7.4e-10 38.4 0.0 1.3e-09 37.6 0.0 1.4 1 0 0 1 1 1 1 S4 domain Macoilin PF09726.9 CCF50179.1 - 0.0023 16.6 2.3 0.0029 16.3 2.3 1.2 1 0 0 1 1 1 1 Macoilin family Apt1 PF10351.9 CCF50179.1 - 0.005 15.8 1.9 0.0076 15.1 1.9 1.3 1 0 0 1 1 1 1 Golgi-body localisation protein domain DDHD PF02862.17 CCF50179.1 - 0.0069 16.6 1.2 0.013 15.7 1.2 1.6 1 0 0 1 1 1 1 DDHD domain Nop14 PF04147.12 CCF50179.1 - 0.013 13.8 10.9 0.018 13.3 10.9 1.1 1 0 0 1 1 1 0 Nop14-like family DUF966 PF06136.13 CCF50179.1 - 0.057 13.1 13.3 0.19 11.4 12.9 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF966) Presenilin PF01080.17 CCF50179.1 - 0.095 11.4 8.3 0.16 10.7 8.3 1.3 1 0 0 1 1 1 0 Presenilin SAPS PF04499.15 CCF50179.1 - 0.27 10.0 6.6 0.38 9.5 6.6 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Suf PF05843.14 CCF50179.1 - 0.91 9.4 6.4 12 5.7 5.6 2.2 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) DUF913 PF06025.12 CCF50179.1 - 1.7 7.6 5.6 3 6.7 5.6 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Hid1 PF12722.7 CCF50179.1 - 4.6 5.3 11.3 6.6 4.7 11.3 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein GREB1 PF15782.5 CCF50179.1 - 5.1 4.1 9.1 7.2 3.6 9.1 1.2 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Menin PF05053.13 CCF50179.1 - 5.7 5.2 10.7 8.4 4.6 10.7 1.2 1 0 0 1 1 1 0 Menin S-AdoMet_synt_C PF02773.16 CCF50180.1 - 5.3e-66 220.8 0.4 1.2e-65 219.7 0.0 1.7 2 0 0 2 2 2 1 S-adenosylmethionine synthetase, C-terminal domain S-AdoMet_synt_M PF02772.16 CCF50180.1 - 9.5e-47 158.2 0.0 2.2e-46 157.0 0.0 1.6 2 0 0 2 2 2 1 S-adenosylmethionine synthetase, central domain S-AdoMet_synt_N PF00438.20 CCF50180.1 - 2.3e-45 153.3 0.3 2.3e-45 153.3 0.3 1.6 2 0 0 2 2 2 1 S-adenosylmethionine synthetase, N-terminal domain AdoMet_Synthase PF01941.19 CCF50180.1 - 0.043 12.6 0.1 0.16 10.7 0.1 1.8 2 0 0 2 2 2 0 S-adenosylmethionine synthetase (AdoMet synthetase) ALS_ss_C PF10369.9 CCF50182.1 - 3.4e-20 72.0 0.0 5.8e-18 64.9 0.0 2.4 2 0 0 2 2 2 2 Small subunit of acetolactate synthase ACT PF01842.25 CCF50182.1 - 1.2e-12 47.4 0.0 2.4e-12 46.4 0.0 1.6 1 0 0 1 1 1 1 ACT domain ACT_5 PF13710.6 CCF50182.1 - 9.2e-07 28.6 0.0 2.9e-06 27.0 0.0 1.9 2 0 0 2 2 2 1 ACT domain DUF2187 PF09953.9 CCF50182.1 - 0.071 13.1 0.1 0.26 11.3 0.1 1.9 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2187) Pkinase PF00069.25 CCF50183.1 - 8.2e-56 189.3 0.0 5.9e-55 186.5 0.0 2.0 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF50183.1 - 1.2e-27 96.8 0.0 3e-26 92.3 0.0 2.5 2 1 0 2 2 2 1 Protein tyrosine kinase Kdo PF06293.14 CCF50183.1 - 3.4e-06 26.6 0.0 5.6e-06 25.9 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family PH_3 PF14593.6 CCF50183.1 - 2.9e-05 24.1 0.0 0.00026 21.1 0.0 2.2 2 0 0 2 2 2 1 PH domain Kinase-like PF14531.6 CCF50183.1 - 0.016 14.6 0.0 0.065 12.5 0.0 1.9 1 1 0 1 1 1 0 Kinase-like APH PF01636.23 CCF50183.1 - 0.064 13.2 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 CCF50183.1 - 0.11 11.5 0.0 0.18 10.7 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain Sugar_tr PF00083.24 CCF50184.1 - 6.4e-130 434.0 20.7 7.5e-130 433.8 20.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF50184.1 - 9.3e-26 90.6 42.7 5.2e-20 71.7 13.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Med1 PF10744.9 CCF50185.1 - 9.7e-10 38.1 0.1 6.6e-06 25.4 0.1 2.4 1 1 0 1 1 1 1 Mediator of RNA polymerase II transcription subunit 1 Methyltransf_11 PF08241.12 CCF50185.1 - 0.00068 20.2 0.0 0.0066 17.1 0.0 2.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF50185.1 - 0.0022 18.7 0.0 0.062 14.0 0.0 3.2 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCF50185.1 - 0.071 13.0 0.0 0.17 11.7 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain CCDC53 PF10152.9 CCF50185.1 - 2.5 8.5 6.9 0.95 9.9 3.2 2.3 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex WD40 PF00400.32 CCF50186.1 - 7.4e-08 32.9 7.5 0.082 13.8 0.1 4.8 6 0 0 6 6 6 3 WD domain, G-beta repeat Nop14 PF04147.12 CCF50187.1 - 0.00026 19.4 25.6 0.00026 19.4 25.6 2.0 2 0 0 2 2 2 1 Nop14-like family SDA1 PF05285.12 CCF50187.1 - 0.00042 19.9 24.3 0.00086 18.8 24.3 1.5 1 0 0 1 1 1 1 SDA1 NUP50 PF08911.11 CCF50187.1 - 0.00044 20.8 12.0 0.00044 20.8 12.0 10.5 8 4 0 8 8 8 1 NUP50 (Nucleoporin 50 kDa) CDC45 PF02724.14 CCF50187.1 - 0.033 12.5 15.4 0.055 11.8 15.4 1.3 1 0 0 1 1 1 0 CDC45-like protein Mpp10 PF04006.12 CCF50187.1 - 5 5.4 26.9 8.8 4.6 26.9 1.3 1 0 0 1 1 1 0 Mpp10 protein Roughex PF06020.11 CCF50187.1 - 6.1 5.8 19.0 13 4.7 19.0 1.5 1 0 0 1 1 1 0 Drosophila roughex protein AAA_12 PF13087.6 CCF50188.1 - 8e-44 149.6 0.0 1.3e-43 149.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain Dna2 PF08696.11 CCF50188.1 - 3.9e-43 147.6 0.0 1.6e-42 145.6 0.0 2.0 1 1 0 1 1 1 1 DNA replication factor Dna2 AAA_11 PF13086.6 CCF50188.1 - 3e-31 109.2 0.4 1.3e-15 58.0 0.0 2.9 2 1 1 3 3 3 2 AAA domain AAA_30 PF13604.6 CCF50188.1 - 1.3e-12 47.8 0.0 1.5e-11 44.4 0.0 2.4 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 CCF50188.1 - 8e-11 42.5 0.1 2.6e-09 37.5 0.0 2.7 2 0 0 2 2 2 1 AAA domain Helicase_RecD PF05127.14 CCF50188.1 - 2.1e-05 24.5 0.0 0.00014 21.8 0.0 2.3 1 1 0 1 1 1 1 Helicase SRP54 PF00448.22 CCF50188.1 - 4.4e-05 23.2 0.1 7.8e-05 22.4 0.1 1.4 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain Cas_Cas4 PF01930.17 CCF50188.1 - 0.00033 20.8 0.9 0.0017 18.5 0.9 2.2 1 1 0 1 1 1 1 Domain of unknown function DUF83 Viral_helicase1 PF01443.18 CCF50188.1 - 0.0016 18.2 0.5 2.1 8.0 0.0 3.4 3 0 0 3 3 3 1 Viral (Superfamily 1) RNA helicase UvrD-helicase PF00580.21 CCF50188.1 - 0.0061 16.1 0.1 0.013 15.0 0.1 1.5 1 0 0 1 1 1 1 UvrD/REP helicase N-terminal domain AAA_7 PF12775.7 CCF50188.1 - 0.0069 15.9 0.1 0.51 9.8 0.0 2.5 2 0 0 2 2 2 1 P-loop containing dynein motor region CbiA PF01656.23 CCF50188.1 - 0.015 15.3 0.0 0.031 14.3 0.0 1.6 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_16 PF13191.6 CCF50188.1 - 0.034 14.5 0.4 1 9.7 0.0 2.8 2 0 0 2 2 2 0 AAA ATPase domain AAA_33 PF13671.6 CCF50188.1 - 0.039 14.1 0.1 0.53 10.4 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_17 PF13207.6 CCF50188.1 - 0.039 14.4 0.0 0.099 13.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain MeaB PF03308.16 CCF50188.1 - 0.057 12.4 0.0 0.11 11.4 0.0 1.4 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB ResIII PF04851.15 CCF50188.1 - 0.072 13.1 0.0 0.16 11.9 0.0 1.6 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit DUF87 PF01935.17 CCF50188.1 - 0.11 12.5 0.2 0.3 11.2 0.2 1.7 1 0 0 1 1 1 0 Helicase HerA, central domain MobB PF03205.14 CCF50188.1 - 0.14 12.0 0.2 0.35 10.8 0.2 1.6 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B NTPase_1 PF03266.15 CCF50188.1 - 0.18 11.7 0.2 0.51 10.2 0.2 1.7 1 0 0 1 1 1 0 NTPase FAD_binding_4 PF01565.23 CCF50189.1 - 8.3e-25 87.2 1.6 1.3e-24 86.5 1.6 1.3 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 CCF50189.1 - 9.6e-10 38.4 0.0 1.8e-09 37.5 0.0 1.4 1 0 0 1 1 1 1 Berberine and berberine like mRNA_triPase PF02940.15 CCF50190.1 - 2e-51 174.8 0.2 2.3e-51 174.6 0.2 1.0 1 0 0 1 1 1 1 mRNA capping enzyme, beta chain RVT_1 PF00078.27 CCF50191.1 - 1.3e-06 28.1 0.0 2.5e-06 27.2 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Phage_integrase PF00589.22 CCF50191.1 - 0.0068 16.2 0.5 0.018 14.9 0.1 1.8 2 0 0 2 2 2 1 Phage integrase family RT_RNaseH_2 PF17919.1 CCF50191.1 - 0.017 15.1 0.0 0.13 12.3 0.0 2.4 3 0 0 3 3 3 0 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 CCF50191.1 - 0.025 14.8 0.0 0.092 13.0 0.0 1.9 2 0 0 2 2 2 0 RNase H-like domain found in reverse transcriptase 2-Hacid_dh_C PF02826.19 CCF50192.1 - 1.1e-34 119.4 0.0 6.8e-34 116.8 0.0 2.0 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 CCF50192.1 - 1.9e-17 63.2 0.0 3.7e-17 62.2 0.0 1.5 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_7 PF13241.6 CCF50192.1 - 0.0091 16.4 0.0 0.023 15.1 0.0 1.6 1 0 0 1 1 1 1 Putative NAD(P)-binding Shikimate_DH PF01488.20 CCF50192.1 - 0.024 14.7 0.0 0.066 13.3 0.0 1.7 1 1 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase NAD_binding_2 PF03446.15 CCF50192.1 - 0.082 13.1 0.0 0.14 12.4 0.0 1.6 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 CCF50192.1 - 0.088 13.4 0.0 0.31 11.7 0.0 2.0 2 1 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent SPX PF03105.19 CCF50193.1 - 0.46 10.3 29.6 0.72 9.7 29.6 1.3 1 0 0 1 1 1 0 SPX domain Presenilin PF01080.17 CCF50193.1 - 3.1 6.5 12.1 4.4 6.0 12.1 1.2 1 0 0 1 1 1 0 Presenilin DUF4551 PF15087.6 CCF50193.1 - 3.9 6.2 15.3 5.1 5.8 15.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) CytochromB561_N PF09786.9 CCF50193.1 - 7.7 5.4 28.5 10 5.0 28.5 1.1 1 0 0 1 1 1 0 Cytochrome B561, N terminal SRP-alpha_N PF04086.13 CCF50193.1 - 7.9 6.3 19.3 11 5.8 19.3 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Cation_ATPase_C PF00689.21 CCF50194.1 - 2.6e-18 66.4 0.2 3.8e-18 65.9 0.2 1.2 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 CCF50194.1 - 4.6e-06 27.1 0.2 1.1e-05 25.8 0.1 1.6 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Ins_P5_2-kin PF06090.12 CCF50195.1 - 1.4e-66 225.2 0.0 1.7e-66 224.9 0.0 1.1 1 0 0 1 1 1 1 Inositol-pentakisphosphate 2-kinase Cmc1 PF08583.10 CCF50196.1 - 1.6e-16 60.0 7.5 1.8e-16 59.9 7.2 1.2 1 1 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like CX9C PF16860.5 CCF50196.1 - 0.00057 19.8 3.2 0.0015 18.5 3.2 1.7 1 1 0 1 1 1 1 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, Pet191_N PF10203.9 CCF50196.1 - 0.0023 18.2 2.9 0.34 11.2 0.5 2.2 2 0 0 2 2 2 2 Cytochrome c oxidase assembly protein PET191 DNApol_Exo PF18136.1 CCF50196.1 - 0.066 12.4 1.8 0.073 12.2 1.8 1.0 1 0 0 1 1 1 0 DNA mitochondrial polymerase exonuclease domain DUF3128 PF11326.8 CCF50196.1 - 1.3 9.5 9.7 26 5.3 5.3 2.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3128) Ribosomal_S3Ae PF01015.18 CCF50197.1 - 3.5e-91 304.3 2.8 4.1e-91 304.0 2.8 1.0 1 0 0 1 1 1 1 Ribosomal S3Ae family Abhydro_lipase PF04083.16 CCF50197.1 - 0.015 14.9 0.0 0.027 14.0 0.0 1.4 1 0 0 1 1 1 0 Partial alpha/beta-hydrolase lipase region ISAV_HA PF06215.11 CCF50197.1 - 0.036 13.2 0.1 0.05 12.7 0.1 1.1 1 0 0 1 1 1 0 Infectious salmon anaemia virus haemagglutinin Ribosomal_S7e PF01251.18 CCF50198.1 - 5.4e-85 283.8 0.3 6.2e-85 283.6 0.3 1.0 1 0 0 1 1 1 1 Ribosomal protein S7e RasGAP PF00616.19 CCF50199.1 - 5.3e-25 88.4 0.0 1e-24 87.4 0.0 1.5 1 0 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase Glyoxalase_3 PF13468.6 CCF50200.1 - 6.1e-25 88.3 0.0 5.8e-24 85.1 0.0 2.3 2 1 0 2 2 2 1 Glyoxalase-like domain Glyoxalase_4 PF13669.6 CCF50200.1 - 0.019 15.2 0.0 1.1 9.6 0.0 2.5 2 0 0 2 2 2 0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily DUF2465 PF10239.9 CCF50203.1 - 0.0039 16.5 0.7 0.0049 16.2 0.7 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2465) SKA2 PF16740.5 CCF50203.1 - 0.12 12.1 5.6 0.063 13.1 1.5 2.1 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 2 DUF4972 PF16342.5 CCF50203.1 - 0.26 11.0 3.3 4.2 7.1 0.2 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4972) KxDL PF10241.9 CCF50203.1 - 1.3 9.4 5.9 2.1 8.7 0.2 2.9 2 1 1 3 3 3 0 Uncharacterized conserved protein BPS1 PF05633.11 CCF50203.1 - 1.9 7.4 6.5 1.9 7.4 5.5 1.3 1 1 0 1 1 1 0 Protein BYPASS1-related Rx_N PF18052.1 CCF50203.1 - 2.4 8.5 10.2 2 8.8 2.0 2.8 1 1 2 3 3 3 0 Rx N-terminal domain Laminin_II PF06009.12 CCF50204.1 - 0.033 14.2 0.3 3.2 7.7 0.1 2.1 1 1 1 2 2 2 0 Laminin Domain II TPR_MLP1_2 PF07926.12 CCF50204.1 - 0.06 13.4 0.4 0.093 12.8 0.4 1.2 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein GYF PF02213.16 CCF50205.1 - 0.00015 21.4 0.2 0.00033 20.3 0.2 1.6 1 0 0 1 1 1 1 GYF domain Pkinase PF00069.25 CCF50206.1 - 4.8e-64 216.3 0.0 4.7e-35 121.2 0.0 3.7 3 1 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.17 CCF50206.1 - 1.1e-34 119.9 0.0 1.7e-16 60.3 0.0 3.7 3 1 0 3 3 3 3 Protein tyrosine kinase HGTP_anticodon2 PF12745.7 CCF50206.1 - 8.8e-19 68.0 2.9 1.3e-15 57.7 0.0 3.8 4 0 0 4 4 4 1 Anticodon binding domain of tRNAs tRNA-synt_His PF13393.6 CCF50206.1 - 4.1e-16 59.1 0.1 4.1e-16 59.1 0.1 1.7 2 0 0 2 2 2 1 Histidyl-tRNA synthetase RWD PF05773.22 CCF50206.1 - 6.6e-16 58.6 0.0 1.6e-15 57.4 0.0 1.7 1 0 0 1 1 1 1 RWD domain Kinase-like PF14531.6 CCF50206.1 - 2.3e-05 23.8 0.0 0.092 12.0 0.0 2.5 2 0 0 2 2 2 2 Kinase-like APH PF01636.23 CCF50206.1 - 0.011 15.6 0.0 0.011 15.6 0.0 3.6 5 0 0 5 5 5 0 Phosphotransferase enzyme family FTA2 PF13095.6 CCF50206.1 - 0.061 13.0 1.8 5.2 6.6 0.0 2.8 3 0 0 3 3 3 0 Kinetochore Sim4 complex subunit FTA2 DPBB_1 PF03330.18 CCF50207.1 - 6.9e-05 23.0 0.0 0.00012 22.3 0.0 1.3 1 0 0 1 1 1 1 Lytic transglycolase Questin_oxidase PF14027.6 CCF50208.1 - 1.3e-76 258.3 0.0 1.9e-76 257.8 0.0 1.2 1 0 0 1 1 1 1 Questin oxidase-like DUF3140 PF11338.8 CCF50209.1 - 1.3e-32 112.0 4.4 3.4e-32 110.7 4.4 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF3140) Med22 PF06179.12 CCF50209.1 - 3.1e-13 49.8 1.5 9e-13 48.4 0.5 2.2 2 0 0 2 2 2 1 Surfeit locus protein 5 subunit 22 of Mediator complex Macoilin PF09726.9 CCF50209.1 - 0.14 10.7 9.8 0.16 10.5 9.8 1.1 1 0 0 1 1 1 0 Macoilin family Draxin PF15550.6 CCF50209.1 - 0.31 10.9 4.4 0.43 10.4 4.4 1.2 1 0 0 1 1 1 0 Draxin DUF3237 PF11578.8 CCF50210.1 - 2.2e-31 108.7 0.1 2.5e-31 108.5 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3237) Zn_clus PF00172.18 CCF50211.1 - 9.6e-06 25.6 9.3 2.4e-05 24.3 9.3 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Methyltransf_8 PF05148.15 CCF50212.1 - 7.9e-50 169.7 0.5 1.1e-23 84.2 0.1 3.5 3 1 0 3 3 3 2 Hypothetical methyltransferase Methyltransf_11 PF08241.12 CCF50212.1 - 0.00012 22.7 0.3 0.00081 20.0 0.0 2.5 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF50212.1 - 0.0003 21.4 0.3 0.0041 17.8 0.1 2.9 3 1 0 3 3 3 1 Methyltransferase domain MTS PF05175.14 CCF50212.1 - 0.034 13.7 0.1 6.2 6.3 0.0 2.4 2 0 0 2 2 2 0 Methyltransferase small domain DUF5582 PF17819.1 CCF50212.1 - 0.072 13.6 0.6 0.23 11.9 0.2 2.0 1 1 0 1 1 1 0 Family of unknown function (DUF5582) Methyltransf_32 PF13679.6 CCF50212.1 - 8.6 6.3 6.2 7.2 6.6 0.0 2.5 2 1 0 2 2 2 0 Methyltransferase domain CDT1_C PF16679.5 CCF50213.1 - 9.8e-14 51.6 0.1 9.8e-14 51.6 0.1 2.9 3 0 0 3 3 3 1 DNA replication factor Cdt1 C-terminal domain Forkhead PF00250.18 CCF50214.1 - 3.6e-18 65.6 0.0 6.1e-18 64.9 0.0 1.3 1 0 0 1 1 1 1 Forkhead domain Astro_capsid_p PF12226.8 CCF50214.1 - 0.031 13.4 8.4 0.069 12.3 8.4 1.5 1 0 0 1 1 1 0 Turkey astrovirus capsid protein Nop14 PF04147.12 CCF50214.1 - 0.1 10.8 20.5 0.2 9.9 20.5 1.4 1 0 0 1 1 1 0 Nop14-like family FHA PF00498.26 CCF50214.1 - 0.13 12.7 0.0 0.66 10.4 0.0 2.0 1 1 0 1 1 1 0 FHA domain Na_trans_assoc PF06512.13 CCF50214.1 - 0.37 11.0 12.8 0.015 15.6 6.1 2.1 2 0 0 2 2 2 0 Sodium ion transport-associated CDC45 PF02724.14 CCF50214.1 - 8.7 4.5 24.2 19 3.4 24.2 1.5 1 0 0 1 1 1 0 CDC45-like protein Ytp1 PF10355.9 CCF50216.1 - 6.5e-103 343.7 1.7 9.6e-103 343.2 1.7 1.2 1 0 0 1 1 1 1 Protein of unknown function (Ytp1) DUF2427 PF10348.9 CCF50216.1 - 3.6e-16 58.8 2.1 3.6e-16 58.8 2.1 2.7 3 0 0 3 3 3 1 Domain of unknown function (DUF2427) Abhydrolase_3 PF07859.13 CCF50217.1 - 6.4e-21 75.2 0.0 1.3e-20 74.2 0.0 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 CCF50217.1 - 2.5e-15 56.2 0.0 4.1e-11 42.4 0.0 2.3 2 0 0 2 2 2 2 Steryl acetyl hydrolase SSB PF00436.25 CCF50218.1 - 4.6e-14 52.3 0.0 5.8e-14 52.0 0.0 1.1 1 0 0 1 1 1 1 Single-strand binding protein family Aminotran_1_2 PF00155.21 CCF50219.1 - 7.3e-74 249.1 0.0 1.3e-73 248.3 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 CCF50219.1 - 7.4e-07 28.4 0.1 1.5e-06 27.5 0.1 1.4 1 0 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 CCF50219.1 - 1.5e-05 24.5 0.2 3.3e-05 23.4 0.2 1.5 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Cys_Met_Meta_PP PF01053.20 CCF50219.1 - 2.5e-05 23.0 0.0 6.2e-05 21.7 0.0 1.5 2 0 0 2 2 2 1 Cys/Met metabolism PLP-dependent enzyme Beta_elim_lyase PF01212.21 CCF50219.1 - 0.007 15.7 0.3 0.013 14.8 0.3 1.6 1 1 0 1 1 1 1 Beta-eliminating lyase Preseq_ALAS PF09029.10 CCF50219.1 - 0.01 16.3 4.0 0.01 16.3 4.0 2.6 1 1 2 3 3 3 0 5-aminolevulinate synthase presequence Ribosomal_L12 PF00542.19 CCF50220.1 - 5.9e-19 68.2 9.3 5e-18 65.2 6.1 2.4 2 0 0 2 2 2 1 Ribosomal protein L7/L12 C-terminal domain Ribosomal_L12_N PF16320.5 CCF50220.1 - 7.2e-15 54.4 12.9 3.7e-14 52.2 9.6 2.8 2 1 0 2 2 2 1 Ribosomal protein L7/L12 dimerisation domain Ribosomal_60s PF00428.19 CCF50220.1 - 0.0041 17.7 9.3 0.0041 17.7 9.3 2.4 2 1 0 2 2 2 1 60s Acidic ribosomal protein Glyco_tran_WecB PF03808.13 CCF50220.1 - 0.032 14.2 0.1 0.049 13.6 0.1 1.3 1 0 0 1 1 1 0 Glycosyl transferase WecB/TagA/CpsF family DAO PF01266.24 CCF50221.1 - 7.8e-51 173.7 0.0 1.2e-50 173.0 0.0 1.3 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 CCF50221.1 - 0.0006 20.3 0.0 0.052 14.1 0.0 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CCF50221.1 - 0.0025 18.0 0.0 0.0061 16.8 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 CCF50221.1 - 0.017 14.4 0.0 0.061 12.6 0.0 1.8 2 0 0 2 2 2 0 Thi4 family Pyr_redox_2 PF07992.14 CCF50221.1 - 0.02 14.2 0.0 0.18 11.0 0.0 2.0 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase TrkA_N PF02254.18 CCF50221.1 - 0.064 13.5 0.0 0.2 11.9 0.0 1.8 2 0 0 2 2 2 0 TrkA-N domain Mqo PF06039.15 CCF50221.1 - 0.1 11.1 0.0 0.22 10.0 0.0 1.5 2 0 0 2 2 2 0 Malate:quinone oxidoreductase (Mqo) Snf7 PF03357.21 CCF50222.1 - 2.3e-43 147.8 13.6 2.3e-43 147.8 13.6 2.0 2 0 0 2 2 2 1 Snf7 LXG PF04740.12 CCF50222.1 - 0.0072 16.1 6.0 0.092 12.5 0.4 2.1 1 1 1 2 2 2 2 LXG domain of WXG superfamily FAM199X PF15814.5 CCF50222.1 - 0.018 14.1 0.1 0.027 13.5 0.1 1.3 1 0 0 1 1 1 0 Protein family FAM199X SBDS_C PF09377.10 CCF50222.1 - 0.075 13.0 3.3 0.14 12.1 3.2 1.7 1 1 0 1 1 1 0 SBDS protein C-terminal domain Ribosomal_60s PF00428.19 CCF50222.1 - 0.076 13.6 3.2 2.3 8.8 0.2 2.6 2 1 0 2 2 2 0 60s Acidic ribosomal protein Atg14 PF10186.9 CCF50222.1 - 0.25 10.4 8.0 0.32 10.1 8.0 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Vps54_N PF10475.9 CCF50222.1 - 0.28 10.4 6.0 1.4 8.2 5.9 1.9 1 1 1 2 2 2 0 Vacuolar-sorting protein 54, of GARP complex THOC7 PF05615.13 CCF50222.1 - 4.3 7.6 12.4 7.2 6.9 9.5 2.4 1 1 2 3 3 3 0 Tho complex subunit 7 DUF1690 PF07956.11 CCF50222.1 - 8.1 6.9 12.2 4.2 7.8 8.9 2.1 1 1 1 2 2 2 0 Protein of Unknown function (DUF1690) RasGEF PF00617.19 CCF50223.1 - 3e-44 151.3 0.0 5.9e-44 150.4 0.0 1.5 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 CCF50223.1 - 3.8e-15 56.0 0.2 1.3e-14 54.3 0.2 2.0 1 0 0 1 1 1 1 RasGEF N-terminal motif MCM PF00493.23 CCF50224.1 - 1.4e-103 344.8 0.0 2.1e-103 344.2 0.0 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 CCF50224.1 - 4e-35 120.4 0.1 8.1e-35 119.4 0.1 1.5 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 CCF50224.1 - 3.5e-29 101.1 0.4 1.1e-28 99.5 0.4 1.9 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 CCF50224.1 - 2.2e-14 53.9 0.1 5.2e-14 52.7 0.1 1.6 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 CCF50224.1 - 2.4e-06 27.1 0.0 0.00096 18.6 0.0 2.3 1 1 1 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 CCF50224.1 - 0.00027 20.9 0.0 0.00054 20.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 CCF50224.1 - 0.0008 19.3 0.1 0.0069 16.2 0.0 2.6 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 CCF50224.1 - 0.1 12.3 0.0 2.8 7.6 0.0 2.3 2 0 0 2 2 2 0 Sigma-54 interaction domain Mg_chelatase_C PF13335.6 CCF50224.1 - 0.11 13.2 0.2 0.34 11.6 0.2 1.9 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI C-terminal FAD-oxidase_C PF02913.19 CCF50225.1 - 0.0067 16.1 0.0 0.0099 15.5 0.0 1.1 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain TIG PF01833.24 CCF50226.1 - 2.3e-12 46.8 2.3 1.2e-11 44.5 1.7 2.6 2 0 0 2 2 2 1 IPT/TIG domain Ank_4 PF13637.6 CCF50226.1 - 1.5e-09 38.2 0.7 1.9e-08 34.7 0.1 2.8 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 CCF50226.1 - 2.1e-09 37.8 0.0 4.9e-09 36.7 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 CCF50226.1 - 7.4e-09 35.7 0.6 2.1e-08 34.3 0.3 2.0 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 CCF50226.1 - 1.4e-08 34.3 0.2 0.0012 19.1 0.0 2.9 2 0 0 2 2 2 2 Ankyrin repeat Ank PF00023.30 CCF50226.1 - 2e-06 28.0 0.5 0.06 13.8 0.1 2.8 2 0 0 2 2 2 2 Ankyrin repeat Sugar_tr PF00083.24 CCF50227.1 - 1.1e-82 278.4 17.5 1.3e-82 278.1 17.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF50227.1 - 6.7e-23 81.2 30.8 8.9e-23 80.8 30.8 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF2157 PF09925.9 CCF50227.1 - 0.1 12.4 7.0 0.33 10.7 7.0 1.9 1 0 0 1 1 1 0 Predicted membrane protein (DUF2157) Sugar_tr PF00083.24 CCF50228.1 - 3e-12 46.2 0.6 3.4e-12 46.0 0.6 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter BNR PF02012.20 CCF50229.1 - 7.7e-07 28.2 7.8 0.042 13.8 0.3 4.5 3 0 0 3 3 3 2 BNR/Asp-box repeat BNR_2 PF13088.6 CCF50229.1 - 1.2e-06 28.1 0.2 2.4e-05 23.8 0.2 2.3 1 1 1 2 2 2 1 BNR repeat-like domain Sortilin-Vps10 PF15902.5 CCF50229.1 - 0.00011 21.2 0.1 0.0011 17.9 0.1 2.1 1 1 0 1 1 1 1 Sortilin, neurotensin receptor 3, BNR_6 PF15899.5 CCF50229.1 - 0.098 12.8 1.7 8.3 6.8 0.1 3.0 2 0 0 2 2 2 0 BNR-Asp box repeat Zn_clus PF00172.18 CCF50230.1 - 1.1e-06 28.6 8.3 1.9e-06 27.8 8.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 CCF50230.1 - 0.005 15.9 0.4 0.0079 15.3 0.4 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain gag_pre-integrs PF13976.6 CCF50232.1 - 0.0027 17.5 0.0 0.0072 16.2 0.0 1.7 1 0 0 1 1 1 1 GAG-pre-integrase domain Spc7_N PF15402.6 CCF50232.1 - 0.13 10.4 0.0 0.21 9.8 0.0 1.2 1 0 0 1 1 1 0 N-terminus of kinetochore NMS complex subunit Spc7 Nop25 PF09805.9 CCF50233.1 - 1.9e-22 80.2 12.6 1.9e-22 80.2 12.6 4.6 5 0 0 5 5 5 1 Nucleolar protein 12 (25kDa) RRM_1 PF00076.22 CCF50233.1 - 0.17 11.7 0.0 0.54 10.1 0.0 2.0 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) LPMO_10 PF03067.15 CCF50234.1 - 1.5e-34 120.4 0.7 1.5e-34 120.4 0.7 1.7 2 0 0 2 2 2 1 Lytic polysaccharide mono-oxygenase, cellulose-degrading CDRN PF05174.12 CCF50234.1 - 0.27 10.9 1.2 27 4.6 0.0 2.5 2 0 0 2 2 2 0 Cysteine-rich D. radiodurans N terminus Macoilin PF09726.9 CCF50234.1 - 1.6 7.2 4.8 2.2 6.7 4.8 1.2 1 0 0 1 1 1 0 Macoilin family DUF515 PF04415.12 CCF50234.1 - 4.8 5.5 9.4 5.9 5.2 9.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF515) Methyltransf_24 PF13578.6 CCF50235.1 - 1.3e-05 26.1 0.0 2.2e-05 25.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltrans_RNA PF04452.14 CCF50235.1 - 0.012 14.9 0.0 0.021 14.2 0.0 1.3 1 0 0 1 1 1 0 RNA methyltransferase UPF0121 PF03661.13 CCF50237.1 - 2e-48 164.9 9.5 2.4e-48 164.6 9.5 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0121) Ribosomal_60s PF00428.19 CCF50237.1 - 0.051 14.2 2.7 2.8 8.6 2.5 2.3 2 0 0 2 2 2 0 60s Acidic ribosomal protein UBA PF00627.31 CCF50238.1 - 4.7e-07 29.6 0.7 1.6e-06 27.9 0.0 2.4 2 0 0 2 2 2 1 UBA/TS-N domain DnaJ PF00226.31 CCF50238.1 - 7.9e-05 22.7 0.3 0.0002 21.4 0.3 1.7 1 0 0 1 1 1 1 DnaJ domain TPR_1 PF00515.28 CCF50238.1 - 0.022 14.6 0.9 1.9 8.4 0.1 3.5 4 0 0 4 4 4 0 Tetratricopeptide repeat RuvA_C PF07499.13 CCF50238.1 - 0.52 10.8 0.0 0.52 10.8 0.0 3.0 4 0 0 4 4 4 0 RuvA, C-terminal domain TPR_2 PF07719.17 CCF50238.1 - 3.6 7.9 11.5 2.7 8.3 0.1 3.5 4 0 0 4 4 4 0 Tetratricopeptide repeat JmjC PF02373.22 CCF50239.1 - 6.7e-39 132.9 0.1 6.7e-39 132.9 0.1 3.1 3 0 0 3 3 3 1 JmjC domain, hydroxylase JmjN PF02375.17 CCF50239.1 - 4.2e-14 52.2 0.0 1.4e-13 50.5 0.0 2.0 1 0 0 1 1 1 1 jmjN domain zf-HC5HC2H_2 PF13832.6 CCF50239.1 - 3.5e-10 40.0 0.9 9.2e-10 38.7 0.9 1.6 1 0 0 1 1 1 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 CCF50239.1 - 1.4e-09 38.0 1.6 4.4e-09 36.5 1.6 1.9 1 0 0 1 1 1 1 PHD-like zinc-binding domain FANCL_C PF11793.8 CCF50239.1 - 0.01 16.0 0.7 0.024 14.8 0.7 1.6 1 0 0 1 1 1 0 FANCL C-terminal domain PHD PF00628.29 CCF50239.1 - 0.11 12.4 2.3 0.38 10.7 2.3 2.0 1 0 0 1 1 1 0 PHD-finger RVT_2 PF07727.14 CCF50240.1 - 1.3e-27 97.0 0.1 2e-27 96.4 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) AMP-binding PF00501.28 CCF50243.1 - 1.1e-69 235.1 0.0 1.4e-69 234.7 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme BCA_ABC_TP_C PF12399.8 CCF50243.1 - 0.17 11.9 0.0 0.4 10.7 0.0 1.7 1 0 0 1 1 1 0 Branched-chain amino acid ATP-binding cassette transporter ATP-synt_J PF04911.12 CCF50244.1 - 1.4e-25 88.6 0.4 1.6e-25 88.4 0.4 1.1 1 0 0 1 1 1 1 ATP synthase j chain MFS_1 PF07690.16 CCF50245.1 - 2.7e-32 112.1 36.5 2.7e-32 112.1 36.5 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF50245.1 - 5.4e-14 51.9 2.5 5.4e-14 51.9 2.5 2.7 3 1 0 3 3 3 1 Sugar (and other) transporter DSPc PF00782.20 CCF50246.1 - 2.5e-19 69.4 0.1 2.2e-17 63.1 0.1 2.3 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 CCF50246.1 - 0.0063 16.1 0.1 0.011 15.3 0.1 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 CCF50246.1 - 0.087 12.9 0.0 0.16 12.1 0.0 1.4 1 0 0 1 1 1 0 Inositol hexakisphosphate DUF382 PF04037.13 CCF50247.1 - 1.8e-56 189.7 1.3 1.8e-56 189.7 1.3 2.9 3 0 0 3 3 3 1 Domain of unknown function (DUF382) PSP PF04046.16 CCF50247.1 - 1.2e-16 60.3 7.7 3.3e-16 58.9 7.7 1.8 1 0 0 1 1 1 1 PSP Roughex PF06020.11 CCF50247.1 - 0.18 10.8 24.5 0.69 8.9 12.2 2.4 2 0 0 2 2 2 0 Drosophila roughex protein DUF3439 PF11921.8 CCF50247.1 - 0.78 9.7 8.8 1.6 8.7 8.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) SSP160 PF06933.11 CCF50247.1 - 2.1 6.4 9.3 3.1 5.9 9.3 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 PCI PF01399.27 CCF50248.1 - 7.8e-10 39.2 0.7 2.4e-09 37.6 0.1 2.3 2 0 0 2 2 2 1 PCI domain Mad3_BUB1_I_2 PF17014.5 CCF50248.1 - 0.12 12.5 0.2 5.5 7.1 0.0 3.3 2 1 1 3 3 3 0 Putative Mad3/BUB1 like region 1 protein Peptidase_M15_2 PF05951.13 CCF50248.1 - 0.51 10.0 0.0 0.51 10.0 0.0 3.3 4 1 0 4 4 4 0 Bacterial protein of unknown function (DUF882) SNARE_assoc PF09335.11 CCF50249.1 - 1.2e-13 51.6 1.0 1.2e-13 51.6 1.0 1.9 2 0 0 2 2 2 1 SNARE associated Golgi protein Proteasome PF00227.26 CCF50250.1 - 6.6e-60 201.8 0.4 8.6e-60 201.5 0.4 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 CCF50250.1 - 4.6e-14 51.8 0.2 1e-13 50.7 0.1 1.7 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature Ion_trans PF00520.31 CCF50251.1 - 5.1e-122 405.8 73.4 2.6e-38 131.6 4.4 5.1 5 0 0 5 5 5 5 Ion transport protein PKD_channel PF08016.12 CCF50251.1 - 0.00057 18.7 5.6 0.00057 18.7 5.6 7.1 6 2 2 8 8 8 4 Polycystin cation channel GPHH PF16905.5 CCF50251.1 - 0.085 12.6 0.0 0.28 11.0 0.0 2.0 1 0 0 1 1 1 0 Voltage-dependent L-type calcium channel, IQ-associated gag_pre-integrs PF13976.6 CCF50253.1 - 2.7e-07 30.3 0.1 9e-07 28.7 0.1 2.0 1 0 0 1 1 1 1 GAG-pre-integrase domain HAD_2 PF13419.6 CCF50254.1 - 3.5e-10 40.2 0.0 9.8e-10 38.8 0.0 1.7 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 CCF50254.1 - 3.5e-06 27.5 0.0 4.9e-05 23.7 0.0 2.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 CCF50254.1 - 0.00049 20.1 0.0 0.00087 19.3 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like Acid_PPase PF12689.7 CCF50254.1 - 0.018 14.9 0.0 0.028 14.3 0.0 1.3 1 0 0 1 1 1 0 Acid Phosphatase COX4 PF02936.14 CCF50255.1 - 3.6e-36 124.2 0.3 6.4e-36 123.4 0.3 1.4 1 1 0 1 1 1 1 Cytochrome c oxidase subunit IV HMG_box_2 PF09011.10 CCF50255.1 - 1.7 9.3 6.8 1.7 9.3 0.1 2.5 2 1 1 3 3 3 0 HMG-box domain SH3BGR PF04908.15 CCF50256.1 - 8.8e-08 32.2 0.9 5e-07 29.8 0.0 2.7 3 0 0 3 3 3 1 SH3-binding, glutamic acid-rich protein PUF PF00806.19 CCF50257.1 - 3.6e-14 51.6 0.1 0.00052 19.5 0.0 5.0 5 0 0 5 5 5 3 Pumilio-family RNA binding repeat CPL PF08144.11 CCF50257.1 - 0.21 12.0 1.3 2.2 8.6 0.2 3.1 2 1 1 3 3 3 0 CPL (NUC119) domain RNase_PH PF01138.21 CCF50258.1 - 1e-22 81.1 0.6 2.3e-22 79.9 0.1 1.9 2 1 0 2 2 2 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 CCF50258.1 - 0.0027 17.7 0.0 0.0085 16.1 0.0 1.9 1 1 0 1 1 1 1 3' exoribonuclease family, domain 2 COG7 PF10191.9 CCF50259.1 - 7e-36 123.8 21.8 1.9e-31 109.1 19.0 2.2 2 0 0 2 2 2 2 Golgi complex component 7 (COG7) Exo84_C PF16528.5 CCF50259.1 - 0.018 14.9 1.5 0.084 12.7 1.5 2.2 1 0 0 1 1 1 0 Exocyst component 84 C-terminal Vps53_N PF04100.12 CCF50259.1 - 0.08 11.9 8.7 0.14 11.1 7.9 1.7 1 1 0 1 1 1 0 Vps53-like, N-terminal CDC37_N PF03234.14 CCF50260.1 - 4.6e-40 137.5 1.7 4.6e-40 137.5 1.7 2.9 3 0 0 3 3 3 1 Cdc37 N terminal kinase binding CDC37_M PF08565.11 CCF50260.1 - 2.5e-24 85.5 0.1 5.5e-24 84.4 0.1 1.6 1 0 0 1 1 1 1 Cdc37 Hsp90 binding domain CDC37_C PF08564.10 CCF50260.1 - 2.1e-16 59.8 0.7 8.7e-16 57.9 0.1 2.3 2 0 0 2 2 2 1 Cdc37 C terminal domain DFRP_C PF16543.5 CCF50260.1 - 0.27 11.7 0.2 0.27 11.7 0.2 3.2 2 1 1 3 3 3 0 DRG Family Regulatory Proteins, Tma46 Fe-S_biosyn PF01521.20 CCF50261.1 - 2.1e-13 50.4 0.0 2.9e-13 50.0 0.0 1.2 1 0 0 1 1 1 1 Iron-sulphur cluster biosynthesis NAC PF01849.18 CCF50262.1 - 6.4e-20 70.9 0.0 1.4e-19 69.8 0.0 1.6 1 0 0 1 1 1 1 NAC domain RR_TM4-6 PF06459.12 CCF50262.1 - 0.047 13.5 6.8 0.059 13.2 6.8 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 TT_ORF2 PF02957.15 CCF50262.1 - 0.068 14.1 0.5 0.12 13.3 0.5 1.5 1 0 0 1 1 1 0 TT viral ORF2 Cytomega_UL84 PF06284.11 CCF50262.1 - 0.079 11.4 0.8 0.087 11.3 0.8 1.1 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein MRNIP PF15749.5 CCF50262.1 - 0.36 11.6 6.4 1.2 9.8 2.8 2.2 2 0 0 2 2 2 0 MRN-interacting protein MscS_TM PF12794.7 CCF50262.1 - 0.37 9.6 1.1 0.43 9.4 1.1 1.2 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 CSRNP_N PF16019.5 CCF50262.1 - 0.68 9.8 5.9 0.87 9.5 2.2 2.0 2 0 0 2 2 2 0 Cysteine/serine-rich nuclear protein N-terminus PGA2 PF07543.12 CCF50262.1 - 5.2 7.1 10.2 1.3 9.0 5.4 1.9 2 0 0 2 2 2 0 Protein trafficking PGA2 RNA_pol_3_Rpc31 PF11705.8 CCF50262.1 - 5.6 7.1 10.7 4.4 7.5 9.7 1.3 1 1 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 DUF3955 PF13127.6 CCF50263.1 - 0.00039 20.2 1.4 0.00039 20.2 1.4 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF3955) CPSF100_C PF13299.6 CCF50263.1 - 0.014 15.6 0.0 5.4 7.2 0.0 2.3 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal EamA PF00892.20 CCF50263.1 - 0.73 10.0 34.0 0.099 12.8 5.1 3.2 3 0 0 3 3 3 0 EamA-like transporter family PMT PF02366.18 CCF50264.1 - 3.8e-74 249.4 18.8 7.3e-74 248.4 18.8 1.5 1 0 0 1 1 1 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 CCF50264.1 - 4.3e-58 196.2 13.7 1e-57 195.0 13.7 1.7 1 0 0 1 1 1 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 CCF50264.1 - 1e-24 87.5 0.6 1.8e-24 86.6 0.6 1.3 1 0 0 1 1 1 1 MIR domain GET2 PF08690.10 CCF50265.1 - 1.4e-14 54.5 13.9 2.3e-08 34.1 0.6 3.4 2 1 0 3 3 3 3 GET complex subunit GET2 Hid1 PF12722.7 CCF50266.1 - 1.4e-131 440.2 0.0 2.2e-131 439.6 0.0 1.3 1 0 0 1 1 1 1 High-temperature-induced dauer-formation protein Dymeclin PF09742.9 CCF50266.1 - 2.2e-64 218.0 0.0 5.5e-64 216.7 0.0 1.5 1 1 0 1 1 1 1 Dyggve-Melchior-Clausen syndrome protein SAPS PF04499.15 CCF50266.1 - 0.11 11.3 0.1 1.3 7.8 0.9 1.9 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein BSD PF03909.17 CCF50267.1 - 1.1e-21 76.5 0.2 1.2e-15 57.3 0.1 2.7 2 0 0 2 2 2 2 BSD domain PH_TFIIH PF08567.11 CCF50267.1 - 1.6e-14 54.0 0.1 3.4e-14 52.9 0.1 1.6 1 0 0 1 1 1 1 TFIIH p62 subunit, N-terminal domain DSPc PF00782.20 CCF50268.1 - 2.8e-07 30.4 0.1 1.1e-06 28.5 0.0 2.0 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain CDKN3 PF05706.12 CCF50268.1 - 0.00075 19.2 0.1 0.0014 18.4 0.1 1.3 1 0 0 1 1 1 1 Cyclin-dependent kinase inhibitor 3 (CDKN3) PTPlike_phytase PF14566.6 CCF50268.1 - 0.0015 18.7 0.0 0.004 17.3 0.0 1.7 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase PF00102.27 CCF50268.1 - 0.012 15.2 0.4 0.096 12.2 0.1 2.1 2 0 0 2 2 2 0 Protein-tyrosine phosphatase Chitin_synth_2 PF03142.15 CCF50269.1 - 4.2e-242 804.4 0.1 5.8e-242 804.0 0.1 1.1 1 0 0 1 1 1 1 Chitin synthase Glyco_tranf_2_3 PF13641.6 CCF50269.1 - 6.6e-12 45.8 0.4 6.2e-11 42.6 0.1 2.1 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.6 CCF50269.1 - 2.2e-11 44.1 6.6 2.2e-11 44.1 6.6 2.3 2 1 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_transf_21 PF13506.6 CCF50269.1 - 0.0046 16.4 0.2 4 6.9 0.0 2.9 3 0 0 3 3 3 2 Glycosyl transferase family 21 DASH_Dad1 PF08649.10 CCF50270.1 - 2.6e-23 82.0 0.2 3.7e-23 81.5 0.2 1.2 1 0 0 1 1 1 1 DASH complex subunit Dad1 RT_RNaseH PF17917.1 CCF50271.1 - 2.7e-08 34.0 0.0 1.2e-07 32.0 0.0 2.2 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 CCF50271.1 - 5e-06 26.5 0.6 0.0014 18.6 0.0 3.3 2 1 1 3 3 3 2 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 CCF50271.1 - 0.00023 21.2 0.3 0.00023 21.2 0.3 2.4 2 0 0 2 2 2 1 Integrase zinc binding domain RVT_1 PF00078.27 CCF50271.1 - 0.0026 17.3 0.1 0.011 15.2 0.1 2.0 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-C3HC4_3 PF13920.6 CCF50273.1 - 1.2e-07 31.4 7.0 1.2e-07 31.4 7.0 3.2 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 CCF50273.1 - 0.0032 17.3 9.3 0.0032 17.3 9.3 4.0 5 0 0 5 5 5 1 Zinc finger, C3HC4 type (RING finger) DEAD PF00270.29 CCF50274.1 - 2.5e-45 154.4 0.3 4.2e-45 153.7 0.3 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CCF50274.1 - 3.6e-32 111.0 0.2 4.2e-31 107.6 0.1 2.5 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 CCF50274.1 - 6e-06 26.4 0.0 9.4e-06 25.7 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 CCF50274.1 - 0.00064 20.1 0.1 0.0048 17.2 0.1 2.2 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 CCF50274.1 - 0.0025 17.6 0.0 0.0046 16.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain CMS1 PF14617.6 CCF50274.1 - 0.015 14.6 0.0 0.031 13.6 0.0 1.5 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit Helicase_RecD PF05127.14 CCF50274.1 - 0.053 13.4 0.0 0.098 12.5 0.0 1.4 1 0 0 1 1 1 0 Helicase Zn_clus PF00172.18 CCF50275.1 - 1.1e-09 38.2 8.5 2e-09 37.4 8.5 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Dabb PF07876.12 CCF50276.1 - 6.6e-15 55.5 0.0 7.3e-15 55.4 0.0 1.0 1 0 0 1 1 1 1 Stress responsive A/B Barrel Domain SNF2_N PF00176.23 CCF50277.1 - 6.5e-61 206.0 0.0 1.2e-60 205.2 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 CCF50277.1 - 9e-19 67.9 0.1 6.1e-18 65.2 0.0 2.4 3 0 0 3 3 3 1 Helicase conserved C-terminal domain HSA PF07529.13 CCF50277.1 - 2.9e-11 43.5 11.2 2.9e-11 43.5 11.2 2.8 2 0 0 2 2 2 1 HSA ResIII PF04851.15 CCF50277.1 - 1.4e-08 34.9 0.0 4.2e-08 33.4 0.0 1.9 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit SUIM_assoc PF16619.5 CCF50277.1 - 1.3 9.1 12.1 6.7 6.9 1.0 3.2 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 HLH PF00010.26 CCF50278.1 - 2.3e-13 49.8 0.0 6.8e-13 48.4 0.0 1.8 1 1 0 1 1 1 1 Helix-loop-helix DNA-binding domain ATP-synt_Eps PF04627.13 CCF50279.1 - 4.6e-22 77.7 3.1 5.5e-22 77.5 3.1 1.1 1 0 0 1 1 1 1 Mitochondrial ATP synthase epsilon chain DUF423 PF04241.15 CCF50280.1 - 1.3e-23 82.9 2.2 1.3e-23 82.9 2.2 1.4 2 0 0 2 2 2 1 Protein of unknown function (DUF423) DUF2627 PF11118.8 CCF50280.1 - 0.0017 18.9 4.0 0.011 16.3 2.1 2.5 1 1 1 2 2 2 1 Protein of unknown function (DUF2627) Gram_pos_anchor PF00746.21 CCF50280.1 - 7.8 6.5 7.8 17 5.4 0.0 3.0 3 0 0 3 3 3 0 LPXTG cell wall anchor motif rve PF00665.26 CCF50282.1 - 8.8e-13 48.5 0.0 1.6e-12 47.6 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain PelD_GGDEF PF16963.5 CCF50284.1 - 0.15 11.9 0.0 0.18 11.6 0.0 1.2 1 0 0 1 1 1 0 PelD GGDEF domain MFS_1 PF07690.16 CCF50285.1 - 1.1e-07 31.1 13.1 4.8e-05 22.4 1.3 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily zinc_ribbon_12 PF11331.8 CCF50286.1 - 1.9 8.3 6.6 4.4 7.2 6.6 1.6 1 0 0 1 1 1 0 Probable zinc-ribbon domain Tyrosinase PF00264.20 CCF50287.1 - 1.4e-18 68.0 3.8 1.4e-18 68.0 3.8 2.1 1 1 1 2 2 2 1 Common central domain of tyrosinase ASFV_J13L PF05568.11 CCF50287.1 - 2.9 7.6 13.6 0.085 12.6 2.7 2.3 1 1 1 2 2 2 0 African swine fever virus J13L protein DUF866 PF05907.13 CCF50288.1 - 3.8e-52 176.3 0.3 4.3e-52 176.1 0.3 1.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF866) Cytochrome_C7 PF14522.6 CCF50288.1 - 0.0028 17.6 0.6 0.0042 17.0 0.6 1.3 1 0 0 1 1 1 1 Cytochrome c7 and related cytochrome c Cytochrom_c3_2 PF14537.6 CCF50288.1 - 0.37 11.3 5.2 1.3 9.5 3.6 2.0 1 1 0 1 1 1 0 Cytochrome c3 Sec15 PF04091.12 CCF50290.1 - 1.8e-82 277.3 0.0 2.9e-82 276.6 0.0 1.3 1 0 0 1 1 1 1 Exocyst complex subunit Sec15-like Sec8_exocyst PF04048.14 CCF50290.1 - 2.4e-05 24.2 1.0 0.0036 17.2 0.3 2.6 2 0 0 2 2 2 2 Sec8 exocyst complex component specific domain COG5 PF10392.9 CCF50290.1 - 0.00041 20.5 0.1 0.00041 20.5 0.1 2.4 3 1 0 3 3 3 1 Golgi transport complex subunit 5 Vps51 PF08700.11 CCF50290.1 - 0.00046 20.2 0.2 0.0021 18.1 0.0 2.3 2 0 0 2 2 2 1 Vps51/Vps67 COG2 PF06148.11 CCF50290.1 - 0.011 15.8 0.9 0.011 15.8 0.9 3.0 3 0 0 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 PI-TkoII_IV PF18714.1 CCF50290.1 - 0.015 14.7 0.1 2.5 7.6 0.0 2.6 2 0 0 2 2 2 0 DNA polymerase II intein Domain IV DPBB_1 PF03330.18 CCF50291.1 - 1.1e-07 32.0 0.7 7.5e-07 29.3 0.1 2.5 2 1 0 2 2 2 1 Lytic transglycolase Barwin PF00967.17 CCF50291.1 - 0.017 15.0 0.0 0.035 14.0 0.0 1.5 1 0 0 1 1 1 0 Barwin family LIM_bind PF01803.16 CCF50291.1 - 0.054 13.0 2.8 0.15 11.5 2.8 1.7 1 1 0 1 1 1 0 LIM-domain binding protein Nop53 PF07767.11 CCF50291.1 - 0.28 10.5 11.0 0.37 10.1 11.0 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) DUF4551 PF15087.6 CCF50291.1 - 3.8 6.2 7.1 4.6 5.9 7.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) CDC45 PF02724.14 CCF50291.1 - 7.1 4.8 7.1 8.8 4.5 7.1 1.1 1 0 0 1 1 1 0 CDC45-like protein Cys_Met_Meta_PP PF01053.20 CCF50292.1 - 2.5e-120 401.5 0.0 3.7e-120 401.0 0.0 1.3 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme GHMP_kinases_N PF00288.26 CCF50292.1 - 2.3e-16 59.8 3.7 3.6e-16 59.1 2.5 2.1 2 0 0 2 2 2 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 CCF50292.1 - 1.5e-06 28.4 0.1 5.3e-05 23.5 0.0 2.7 1 1 1 2 2 2 2 GHMP kinases C terminal GalKase_gal_bdg PF10509.9 CCF50292.1 - 0.0063 16.0 0.2 0.018 14.6 0.2 1.8 1 0 0 1 1 1 1 Galactokinase galactose-binding signature FTCD_C PF04961.12 CCF50292.1 - 0.12 12.1 0.4 5.9 6.6 0.1 2.6 2 0 0 2 2 2 0 Formiminotransferase-cyclodeaminase NTF2 PF02136.20 CCF50293.1 - 8.1e-10 39.3 0.1 1e-07 32.5 0.0 2.6 3 0 0 3 3 3 2 Nuclear transport factor 2 (NTF2) domain Mtr2 PF10429.9 CCF50293.1 - 4.4e-08 33.2 0.0 5.3e-08 33.0 0.0 1.2 1 0 0 1 1 1 1 Nuclear pore RNA shuttling protein Mtr2 RNR_inhib PF08591.10 CCF50294.1 - 0.92 10.8 0.1 0.92 10.8 0.1 2.9 3 1 0 3 3 3 0 Ribonucleotide reductase inhibitor Oxysterol_BP PF01237.18 CCF50295.1 - 2.8e-91 306.1 2.7 2.7e-89 299.6 2.7 2.0 1 1 0 1 1 1 1 Oxysterol-binding protein DUF1676 PF07898.13 CCF50297.1 - 0.056 13.5 3.0 0.15 12.1 3.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1676) TPR_1 PF00515.28 CCF50299.1 - 1.6e-54 179.6 29.0 8.8e-08 31.7 0.1 10.8 11 1 0 11 11 10 9 Tetratricopeptide repeat TPR_2 PF07719.17 CCF50299.1 - 6.8e-50 163.2 24.5 3.1e-06 26.9 0.1 10.7 11 0 0 11 11 10 9 Tetratricopeptide repeat TPR_8 PF13181.6 CCF50299.1 - 2.3e-39 130.3 18.5 4.7e-06 26.4 0.0 11.0 10 1 0 10 10 10 8 Tetratricopeptide repeat TPR_14 PF13428.6 CCF50299.1 - 3.9e-29 98.8 13.0 0.00038 21.0 0.0 9.1 3 2 6 9 9 9 7 Tetratricopeptide repeat TPR_17 PF13431.6 CCF50299.1 - 9.7e-25 85.1 23.4 0.00041 20.5 0.2 10.4 11 0 0 11 11 11 5 Tetratricopeptide repeat TPR_19 PF14559.6 CCF50299.1 - 5e-24 84.6 15.4 1.2e-05 25.7 0.1 6.7 6 2 2 8 8 7 6 Tetratricopeptide repeat TPR_7 PF13176.6 CCF50299.1 - 6.2e-24 82.2 14.1 0.019 15.0 0.1 9.7 10 0 0 10 10 9 5 Tetratricopeptide repeat TPR_12 PF13424.6 CCF50299.1 - 1.2e-23 83.1 17.0 8.4e-06 26.0 0.2 7.3 3 3 3 6 6 6 4 Tetratricopeptide repeat TPR_16 PF13432.6 CCF50299.1 - 7.3e-23 80.9 32.3 7.2e-05 23.4 0.8 8.5 5 3 1 7 7 7 5 Tetratricopeptide repeat TPR_6 PF13174.6 CCF50299.1 - 1.9e-20 72.0 19.5 0.0053 17.3 0.0 10.4 11 0 0 11 11 10 5 Tetratricopeptide repeat TPR_11 PF13414.6 CCF50299.1 - 4.5e-20 71.0 33.3 3.3e-06 26.7 1.6 9.7 4 2 5 9 9 9 5 TPR repeat TPR_9 PF13371.6 CCF50299.1 - 1.1e-17 63.9 9.8 0.03 14.5 0.3 6.0 3 2 3 6 6 6 6 Tetratricopeptide repeat ANAPC3 PF12895.7 CCF50299.1 - 1.5e-10 41.2 7.6 1.7e-06 28.2 1.2 3.6 4 0 0 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_15 PF13429.6 CCF50299.1 - 8.8e-09 35.0 12.1 0.017 14.4 1.5 5.2 2 1 2 4 4 4 3 Tetratricopeptide repeat TPR_21 PF09976.9 CCF50299.1 - 0.00022 21.0 4.1 1.8 8.3 0.2 4.4 4 1 0 4 4 4 2 Tetratricopeptide repeat-like domain DUF4919 PF16266.5 CCF50299.1 - 0.0041 17.1 0.1 0.18 11.7 0.0 2.5 2 1 0 2 2 2 1 Domain of unknown function (DUF4919) TPR_10 PF13374.6 CCF50299.1 - 0.011 15.6 19.0 3.7 7.6 0.0 7.0 7 0 0 7 7 7 0 Tetratricopeptide repeat ChAPs PF09295.10 CCF50299.1 - 0.026 13.6 0.7 1.9 7.4 0.1 2.7 2 1 0 3 3 3 0 ChAPs (Chs5p-Arf1p-binding proteins) BTAD PF03704.17 CCF50299.1 - 0.027 14.9 8.5 3.6 8.0 0.4 3.7 3 0 0 3 3 3 0 Bacterial transcriptional activator domain DUF2225 PF09986.9 CCF50299.1 - 0.034 13.8 3.7 1.6 8.4 1.6 2.6 2 1 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2225) TPR_20 PF14561.6 CCF50299.1 - 0.064 13.6 0.0 0.064 13.6 0.0 4.1 5 1 1 6 6 4 0 Tetratricopeptide repeat TOM20_plant PF06552.12 CCF50299.1 - 0.09 12.5 1.0 22 4.7 0.4 3.5 3 1 0 3 3 3 0 Plant specific mitochondrial import receptor subunit TOM20 Rapsyn_N PF10579.9 CCF50299.1 - 0.13 12.4 0.3 15 5.8 0.0 3.4 3 1 1 4 4 3 0 Rapsyn N-terminal myristoylation and linker region SNAP PF14938.6 CCF50299.1 - 0.34 10.3 14.3 8.8 5.7 3.8 4.7 2 1 1 3 3 3 0 Soluble NSF attachment protein, SNAP Fis1_TPR_C PF14853.6 CCF50299.1 - 1.6 8.8 10.6 44 4.2 0.0 5.8 6 1 1 7 7 7 0 Fis1 C-terminal tetratricopeptide repeat Actin PF00022.19 CCF50300.1 - 8.1e-50 169.6 0.0 7.1e-26 90.7 0.0 2.4 2 0 0 2 2 2 2 Actin Nop52 PF05997.12 CCF50301.1 - 1.1e-76 257.4 3.4 1.1e-76 257.4 3.4 2.9 2 1 0 2 2 2 1 Nucleolar protein,Nop52 DUF4050 PF13259.6 CCF50301.1 - 0.0012 19.2 4.8 0.0012 19.2 4.8 3.9 3 1 0 3 3 2 1 Protein of unknown function (DUF4050) CPSF100_C PF13299.6 CCF50301.1 - 0.0072 16.5 8.8 0.0072 16.5 8.8 4.2 3 1 1 4 4 4 1 Cleavage and polyadenylation factor 2 C-terminal PPL5 PF18168.1 CCF50301.1 - 0.01 15.1 4.6 0.01 15.1 4.6 3.0 3 0 0 3 3 3 0 Prim-pol family 5 Peroxin-13_N PF04088.13 CCF50301.1 - 0.013 15.8 5.1 0.74 10.1 0.9 3.2 3 1 0 3 3 3 0 Peroxin 13, N-terminal region ATP11 PF06644.11 CCF50301.1 - 0.02 14.7 0.3 0.02 14.7 0.3 3.6 3 1 1 4 4 4 0 ATP11 protein PIP5K PF01504.18 CCF50301.1 - 0.021 14.1 0.5 0.021 14.1 0.5 2.6 2 1 0 2 2 1 0 Phosphatidylinositol-4-phosphate 5-Kinase DUF775 PF05603.12 CCF50301.1 - 0.06 12.9 6.9 2.8 7.5 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF775) SID-1_RNA_chan PF13965.6 CCF50301.1 - 0.2 10.0 5.4 0.18 10.2 0.4 2.2 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 DUF4770 PF15994.5 CCF50301.1 - 4.5 7.5 14.1 0.16 12.2 6.3 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4770) MRP-S27 PF10037.9 CCF50301.1 - 8.4 5.1 21.5 0.87 8.4 9.7 2.3 2 0 0 2 2 2 0 Mitochondrial 28S ribosomal protein S27 GTP_EFTU PF00009.27 CCF50302.1 - 2.8e-21 76.0 0.0 5.7e-21 75.0 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 CCF50302.1 - 2.7e-07 30.9 0.6 8.3e-07 29.3 0.6 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 CCF50302.1 - 0.015 15.3 0.1 0.048 13.7 0.1 1.9 1 1 0 1 1 1 0 50S ribosome-binding GTPase GTP_EFTU_D4 PF14578.6 CCF50302.1 - 0.037 13.9 1.0 2.9 7.9 0.2 2.7 2 0 0 2 2 2 0 Elongation factor Tu domain 4 RsgA_GTPase PF03193.16 CCF50302.1 - 0.092 12.6 0.1 13 5.7 0.0 2.5 2 0 0 2 2 2 0 RsgA GTPase SOBP PF15279.6 CCF50302.1 - 0.1 13.2 5.7 0.19 12.3 5.7 1.4 1 0 0 1 1 1 0 Sine oculis-binding protein FeoB_N PF02421.18 CCF50302.1 - 0.11 12.0 0.1 6.4 6.3 0.0 2.5 2 0 0 2 2 2 0 Ferrous iron transport protein B ATP_bind_1 PF03029.17 CCF50302.1 - 0.17 11.6 0.1 19 4.9 0.0 2.3 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein adh_short_C2 PF13561.6 CCF50303.1 - 1.3e-50 172.1 0.0 1.8e-50 171.7 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCF50303.1 - 2.1e-43 148.1 0.0 2.6e-43 147.8 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CCF50303.1 - 3.6e-06 27.0 0.0 5.4e-06 26.4 0.0 1.2 1 0 0 1 1 1 1 KR domain THF_DHG_CYH_C PF02882.19 CCF50303.1 - 0.055 12.8 0.0 0.095 12.0 0.0 1.3 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain TPT PF03151.16 CCF50304.1 - 7.9e-22 77.9 17.9 9.7e-22 77.6 17.9 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 CCF50304.1 - 1.5e-05 25.2 31.3 0.01 16.0 13.6 2.3 2 0 0 2 2 2 2 EamA-like transporter family UAA PF08449.11 CCF50304.1 - 0.24 10.5 20.2 1 8.5 20.3 1.9 1 1 0 1 1 1 0 UAA transporter family Med31 PF05669.12 CCF50305.1 - 1.4e-33 114.7 1.0 1.8e-33 114.4 1.0 1.1 1 0 0 1 1 1 1 SOH1 GSH_synth_ATP PF03917.17 CCF50306.1 - 1.8e-127 425.2 0.0 2e-127 425.0 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic glutathione synthase, ATP binding domain GSH_synthase PF03199.15 CCF50306.1 - 5.5e-34 116.7 0.0 9.4e-34 116.0 0.0 1.4 1 0 0 1 1 1 1 Eukaryotic glutathione synthase V-ATPase_H_N PF03224.14 CCF50307.1 - 6.1e-105 351.0 0.0 3.2e-104 348.6 0.0 2.0 2 0 0 2 2 2 1 V-ATPase subunit H V-ATPase_H_C PF11698.8 CCF50307.1 - 5.3e-37 126.5 0.0 1.1e-36 125.4 0.0 1.6 1 0 0 1 1 1 1 V-ATPase subunit H Arm PF00514.23 CCF50307.1 - 0.0065 16.5 2.5 1.2 9.3 0.1 4.6 5 0 0 5 5 5 1 Armadillo/beta-catenin-like repeat TEX12 PF15219.6 CCF50307.1 - 0.15 12.4 0.1 0.31 11.4 0.1 1.5 1 0 0 1 1 1 0 Testis-expressed 12 MRP-L46 PF11788.8 CCF50308.1 - 4e-24 85.7 0.0 8.2e-24 84.6 0.0 1.6 1 0 0 1 1 1 1 39S mitochondrial ribosomal protein L46 ATG16 PF08614.11 CCF50309.1 - 7.2e-57 192.9 19.1 8.9e-57 192.6 19.1 1.1 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) DUF4407 PF14362.6 CCF50309.1 - 0.0045 16.4 5.8 0.0055 16.1 5.8 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4407) Shugoshin_N PF07558.11 CCF50309.1 - 0.01 15.7 1.9 0.62 10.0 0.6 2.6 2 0 0 2 2 2 0 Shugoshin N-terminal coiled-coil region Mito_fiss_reg PF05308.11 CCF50309.1 - 0.032 14.3 8.8 0.06 13.4 8.0 1.7 1 1 1 2 2 2 0 Mitochondrial fission regulator kleA_kleC PF17383.2 CCF50309.1 - 0.055 13.8 3.5 0.1 13.0 0.5 2.8 2 1 1 3 3 3 0 Uncharacterized KorC regulated protein A DUF4457 PF14652.6 CCF50309.1 - 0.06 12.6 0.5 0.11 11.7 0.4 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4457) Fib_alpha PF08702.10 CCF50309.1 - 0.45 10.7 11.0 0.32 11.2 7.9 2.0 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Atg14 PF10186.9 CCF50309.1 - 0.63 9.1 17.8 0.015 14.4 10.7 1.8 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 TMF_TATA_bd PF12325.8 CCF50309.1 - 0.64 10.2 26.7 0.03 14.5 10.2 2.7 2 1 1 3 3 3 0 TATA element modulatory factor 1 TATA binding Peptidase_S46 PF10459.9 CCF50309.1 - 0.7 8.5 7.3 0.99 8.0 7.3 1.1 1 0 0 1 1 1 0 Peptidase S46 FlaC_arch PF05377.11 CCF50309.1 - 0.86 10.0 13.2 1.6 9.1 0.6 3.9 3 1 1 4 4 4 0 Flagella accessory protein C (FlaC) FUSC PF04632.12 CCF50309.1 - 1.2 7.6 6.6 1.9 6.9 6.6 1.3 1 0 0 1 1 1 0 Fusaric acid resistance protein family GAS PF13851.6 CCF50309.1 - 2.8 7.3 22.7 0.31 10.4 16.1 2.1 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding Exonuc_VII_L PF02601.15 CCF50309.1 - 7 6.1 13.5 1.2 8.6 9.8 1.5 2 0 0 2 2 2 0 Exonuclease VII, large subunit YabA PF06156.13 CCF50309.1 - 7.1 7.3 15.3 1.5 9.5 3.9 3.2 2 1 1 3 3 3 0 Initiation control protein YabA USP8_interact PF08941.10 CCF50309.1 - 7.9 6.3 9.9 0.3 10.9 2.0 2.3 2 1 1 3 3 3 0 USP8 interacting TMPIT PF07851.13 CCF50309.1 - 8.1 5.6 7.2 5.7 6.1 4.9 1.6 1 1 0 1 1 1 0 TMPIT-like protein DASH_Dam1 PF08653.10 CCF50309.1 - 8.1 6.3 9.8 5.3 6.9 0.7 3.5 3 1 0 3 3 3 0 DASH complex subunit Dam1 FAM76 PF16046.5 CCF50309.1 - 8.9 5.6 10.7 83 2.4 10.7 2.0 1 1 0 1 1 1 0 FAM76 protein MFAP1 PF06991.11 CCF50310.1 - 6.1e-58 196.2 21.6 6.1e-58 196.2 21.6 2.6 2 0 0 2 2 2 1 Microfibril-associated/Pre-mRNA processing Zn_clus PF00172.18 CCF50311.1 - 6.3e-05 23.0 8.9 0.00012 22.2 8.9 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain GATA PF00320.27 CCF50313.1 - 1.9e-06 27.3 2.7 3.2e-06 26.6 2.7 1.4 1 0 0 1 1 1 1 GATA zinc finger Ntox28 PF15605.6 CCF50313.1 - 0.099 12.9 0.1 0.21 11.9 0.1 1.5 1 0 0 1 1 1 0 Bacterial toxin 28 Paf1 PF03985.13 CCF50314.1 - 2.3 7.1 11.4 10 5.0 5.9 2.6 2 0 0 2 2 2 0 Paf1 DNA_pol_phi PF04931.13 CCF50314.1 - 4.1 5.4 14.3 8.6 4.3 14.3 1.4 1 0 0 1 1 1 0 DNA polymerase phi PAM2 PF07145.15 CCF50315.1 - 8.5e-06 25.1 3.0 5.7 6.9 0.0 5.6 5 0 0 5 5 5 3 Ataxin-2 C-terminal region Trns_repr_metal PF02583.17 CCF50315.1 - 0.011 16.1 1.2 0.011 16.1 1.2 3.5 4 0 0 4 4 4 0 Metal-sensitive transcriptional repressor Hema_stalk PF08720.10 CCF50315.1 - 0.17 11.6 0.2 0.34 10.6 0.2 1.5 1 0 0 1 1 1 0 Influenza C hemagglutinin stalk Med7 PF05983.11 CCF50316.1 - 4.3e-53 180.2 2.6 6.5e-53 179.7 2.6 1.3 1 0 0 1 1 1 1 MED7 protein DUF4239 PF14023.6 CCF50316.1 - 0.078 12.7 0.9 0.13 12.0 0.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4239) MIT PF04212.18 CCF50316.1 - 0.5 10.5 3.1 1.1 9.4 3.1 1.6 1 0 0 1 1 1 0 MIT (microtubule interacting and transport) domain Aminotran_5 PF00266.19 CCF50317.1 - 6.8e-36 124.0 0.0 2.8e-35 121.9 0.0 1.8 1 1 0 1 1 1 1 Aminotransferase class-V RF-1 PF00472.20 CCF50318.1 - 1.1e-22 80.1 3.5 3e-22 78.7 3.5 1.6 1 0 0 1 1 1 1 RF-1 domain aGPT-Pplase1 PF18723.1 CCF50319.1 - 2e-88 296.5 0.1 4.4e-88 295.4 0.0 1.5 2 0 0 2 2 2 1 alpha-glutamyl/putrescinyl thymine pyrophosphorylase clade 1 Chromo PF00385.24 CCF50319.1 - 4.7e-06 26.4 0.1 9.1e-06 25.5 0.1 1.4 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Y_phosphatase2 PF03162.13 CCF50320.1 - 1.6e-39 135.2 0.0 4.8e-23 81.5 0.0 2.1 2 0 0 2 2 2 2 Tyrosine phosphatase family Slx4 PF09494.10 CCF50321.1 - 1.8e-17 63.0 0.0 3.5e-17 62.1 0.0 1.5 1 0 0 1 1 1 1 Slx4 endonuclease Glyco_hydro_cc PF11790.8 CCF50322.1 - 9.5e-63 211.9 4.0 1.2e-62 211.7 4.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase catalytic core Glyco_hydro_39 PF01229.17 CCF50322.1 - 0.069 11.7 0.0 1.4 7.5 0.0 2.1 2 0 0 2 2 2 0 Glycosyl hydrolases family 39 Antimicrobial11 PF08106.11 CCF50322.1 - 0.35 11.0 2.5 0.63 10.2 2.5 1.4 1 0 0 1 1 1 0 Formaecin family EamA PF00892.20 CCF50323.1 - 4.7e-08 33.3 6.8 4.7e-08 33.3 6.8 3.5 4 0 0 4 4 4 2 EamA-like transporter family CSG2 PF16965.5 CCF50323.1 - 0.00027 20.0 0.0 0.00067 18.7 0.0 1.6 1 0 0 1 1 1 1 Ceramide synthase regulator AlphaC_C PF17480.2 CCF50323.1 - 0.13 12.3 0.0 0.34 11.0 0.0 1.6 1 0 0 1 1 1 0 AlphaC C-terminal Sec20 PF03908.13 CCF50324.1 - 1.8e-17 63.0 1.6 1.8e-17 63.0 1.6 2.2 2 0 0 2 2 2 1 Sec20 Med30 PF11315.8 CCF50324.1 - 0.019 15.2 0.5 0.019 15.2 0.5 2.0 3 0 0 3 3 3 0 Mediator complex subunit 30 Glypican PF01153.19 CCF50324.1 - 0.03 13.2 0.5 0.044 12.6 0.5 1.2 1 0 0 1 1 1 0 Glypican Syntaxin-6_N PF09177.11 CCF50324.1 - 0.045 14.3 10.3 0.22 12.1 0.9 3.5 3 1 0 3 3 3 0 Syntaxin 6, N-terminal 7TMR-HDED PF07697.11 CCF50324.1 - 0.13 12.4 5.9 0.3 11.2 5.9 1.7 1 1 0 1 1 1 0 7TM-HD extracellular Baculo_PEP_C PF04513.12 CCF50324.1 - 1.5 8.9 9.8 0.36 10.9 0.7 3.1 3 0 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF5344 PF17279.2 CCF50324.1 - 3.3 8.3 7.8 0.34 11.5 0.5 2.7 3 0 0 3 3 3 0 Family of unknown function (DUF5344) HisKA_3 PF07730.13 CCF50324.1 - 7.7 7.1 15.0 0.24 12.0 4.1 3.6 3 1 1 4 4 4 0 Histidine kinase Ribosomal_L16 PF00252.18 CCF50325.1 - 1.2e-40 138.6 0.2 1.5e-40 138.2 0.2 1.1 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e HSCB_C PF07743.13 CCF50326.1 - 1.9e-18 66.7 10.0 3.4e-18 65.9 10.0 1.4 1 0 0 1 1 1 1 HSCB C-terminal oligomerisation domain DnaJ PF00226.31 CCF50326.1 - 3.9e-05 23.7 0.0 8.8e-05 22.6 0.0 1.6 1 0 0 1 1 1 1 DnaJ domain DZR PF12773.7 CCF50326.1 - 0.016 15.2 0.9 0.032 14.3 0.9 1.4 1 0 0 1 1 1 0 Double zinc ribbon Histone_HNS PF00816.21 CCF50326.1 - 0.36 11.7 3.7 0.66 10.8 3.7 1.4 1 0 0 1 1 1 0 H-NS histone family zf_C2H2_10 PF18414.1 CCF50326.1 - 0.69 9.5 6.3 4 7.1 0.3 2.7 2 0 0 2 2 2 0 C2H2 type zinc-finger DUF2508 PF10704.9 CCF50326.1 - 0.78 10.0 4.1 2.6 8.3 4.0 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF2508) UPF0547 PF10571.9 CCF50326.1 - 1 9.5 4.9 2 8.6 4.9 1.4 1 0 0 1 1 1 0 Uncharacterised protein family UPF0547 PSP1 PF04468.12 CCF50327.1 - 2.7e-29 101.3 0.7 3.9e-29 100.8 0.7 1.2 1 0 0 1 1 1 1 PSP1 C-terminal conserved region EF-hand_4 PF12763.7 CCF50328.1 - 1.7e-38 130.7 0.0 7.3e-15 54.8 0.0 3.5 3 0 0 3 3 3 3 Cytoskeletal-regulatory complex EF hand UBA PF00627.31 CCF50328.1 - 7.4e-06 25.8 0.0 1.5e-05 24.7 0.0 1.6 1 0 0 1 1 1 1 UBA/TS-N domain EF-hand_7 PF13499.6 CCF50328.1 - 0.00013 22.4 0.0 2.5 8.6 0.0 3.8 4 0 0 4 4 4 1 EF-hand domain pair UBA_3 PF09288.10 CCF50328.1 - 0.00013 21.6 0.0 0.0003 20.5 0.0 1.5 1 0 0 1 1 1 1 Fungal ubiquitin-associated domain zf-C4H2 PF10146.9 CCF50328.1 - 0.0038 17.6 5.1 0.0038 17.6 5.1 2.2 2 0 0 2 2 2 1 Zinc finger-containing protein Macoilin PF09726.9 CCF50328.1 - 0.54 8.8 16.1 0.88 8.0 16.1 1.2 1 0 0 1 1 1 0 Macoilin family ATG16 PF08614.11 CCF50328.1 - 1.4 9.1 32.5 1.7 8.8 30.0 2.4 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) TolA_bind_tri PF16331.5 CCF50328.1 - 2 8.5 19.7 6.2 7.0 6.5 3.0 2 1 0 2 2 2 0 TolA binding protein trimerisation GAS PF13851.6 CCF50328.1 - 2.3 7.5 31.3 1.7 7.9 27.5 2.0 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding Spc7 PF08317.11 CCF50328.1 - 7.6 5.3 31.4 1.9 7.3 26.8 1.8 1 1 1 2 2 2 0 Spc7 kinetochore protein PAC2 PF09754.9 CCF50329.1 - 3.2e-25 89.4 0.0 4.5e-25 88.9 0.0 1.1 1 0 0 1 1 1 1 PAC2 family Proteasome PF00227.26 CCF50330.1 - 5e-50 169.6 0.1 6.5e-50 169.3 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Pr_beta_C PF12465.8 CCF50330.1 - 1.1e-07 31.2 0.1 1.1e-07 31.2 0.1 1.7 2 0 0 2 2 2 1 Proteasome beta subunits C terminal DUF4116 PF13475.6 CCF50330.1 - 0.049 13.4 0.0 0.083 12.6 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4116) Aminotran_4 PF01063.19 CCF50331.1 - 1.8e-29 103.2 0.0 4.8e-29 101.8 0.0 1.7 1 1 0 1 1 1 1 Amino-transferase class IV RNA_POL_M_15KD PF02150.16 CCF50332.1 - 1e-12 47.7 2.6 1e-12 47.7 2.6 3.3 4 0 0 4 4 4 1 RNA polymerases M/15 Kd subunit TFIIS_C PF01096.18 CCF50332.1 - 1.3e-10 40.9 8.3 5.5e-10 38.9 0.6 3.0 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) Zn-ribbon_8 PF09723.10 CCF50332.1 - 0.014 15.5 7.0 7.2 6.8 0.0 3.8 4 0 0 4 4 4 0 Zinc ribbon domain CpXC PF14353.6 CCF50332.1 - 0.12 12.4 7.7 4.1 7.5 1.0 3.2 1 1 2 3 3 3 0 CpXC protein DUF3268 PF11672.8 CCF50332.1 - 0.23 11.8 2.3 3.3 8.1 0.1 2.3 2 0 0 2 2 2 0 zinc-finger-containing domain zinc_ribbon_12 PF11331.8 CCF50332.1 - 0.68 9.8 10.1 1.9 8.4 0.4 3.8 4 0 0 4 4 4 0 Probable zinc-ribbon domain HypA PF01155.19 CCF50332.1 - 2.2 8.3 5.1 0.27 11.3 0.2 2.0 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Rpr2 PF04032.16 CCF50332.1 - 5.2 7.4 7.8 36 4.7 7.9 2.4 1 1 0 1 1 1 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain Zn_Tnp_IS1595 PF12760.7 CCF50332.1 - 7.3 6.6 11.5 2.6 8.1 0.6 2.7 2 1 0 2 2 2 0 Transposase zinc-ribbon domain Sel1 PF08238.12 CCF50333.1 - 3.3e-09 37.1 21.1 0.0008 20.0 0.6 4.5 4 0 0 4 4 4 3 Sel1 repeat TPR_2 PF07719.17 CCF50333.1 - 0.19 11.9 0.5 1.7 9.0 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat Vma12 PF11712.8 CCF50334.1 - 5.2e-34 117.3 0.5 8.7e-34 116.6 0.2 1.5 2 0 0 2 2 2 1 Endoplasmic reticulum-based factor for assembly of V-ATPase TPR_14 PF13428.6 CCF50334.1 - 0.84 10.6 3.9 1.7 9.7 0.1 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF89 PF01937.19 CCF50335.1 - 8.6e-110 367.0 0.0 1.2e-78 264.5 0.0 2.0 2 0 0 2 2 2 2 Protein of unknown function DUF89 Cofac_haem_bdg PF04187.13 CCF50336.1 - 1.6e-28 100.2 0.2 2.2e-23 83.4 0.0 3.4 2 1 0 2 2 2 2 Haem-binding uptake, Tiki superfamily, ChaN DPBB_1 PF03330.18 CCF50337.1 - 0.028 14.7 0.1 0.1 12.9 0.1 1.9 1 1 0 1 1 1 0 Lytic transglycolase Not1 PF04054.15 CCF50339.1 - 2.1e-121 405.3 0.0 5.9e-121 403.8 0.0 1.8 1 0 0 1 1 1 1 CCR4-Not complex component, Not1 CNOT1_CAF1_bind PF16415.5 CCF50339.1 - 3.6e-96 320.9 0.6 1.1e-95 319.3 0.6 1.9 1 0 0 1 1 1 1 CCR4-NOT transcription complex subunit 1 CAF1-binding domain DUF3819 PF12842.7 CCF50339.1 - 1.7e-56 190.2 3.8 1.7e-56 190.2 3.8 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF3819) CNOT1_TTP_bind PF16417.5 CCF50339.1 - 5.4e-54 182.3 0.0 5.4e-54 182.3 0.0 3.2 3 0 0 3 3 3 1 CCR4-NOT transcription complex subunit 1 TTP binding domain CNOT1_HEAT PF16418.5 CCF50339.1 - 7.3e-41 139.7 0.7 7.3e-41 139.7 0.7 3.0 3 0 0 3 3 3 1 CCR4-NOT transcription complex subunit 1 HEAT repeat TFIIA PF03153.13 CCF50339.1 - 0.23 11.4 15.8 0.54 10.2 15.8 1.6 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Suf PF05843.14 CCF50339.1 - 8.3 6.3 7.0 19 5.1 7.0 1.5 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) WW PF00397.26 CCF50340.1 - 0.0003 20.8 10.8 0.074 13.1 7.3 2.6 2 0 0 2 2 2 2 WW domain Pkinase PF00069.25 CCF50342.1 - 8.5e-70 235.1 0.0 1.1e-69 234.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF50342.1 - 2.4e-49 168.0 0.0 3.3e-49 167.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CCF50342.1 - 2.8e-06 26.4 0.6 5e-06 25.5 0.0 1.6 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 CCF50342.1 - 0.00019 20.9 0.0 0.00038 19.9 0.0 1.4 1 0 0 1 1 1 1 Kinase-like ABC1 PF03109.16 CCF50342.1 - 0.055 13.6 0.0 0.14 12.4 0.0 1.6 1 0 0 1 1 1 0 ABC1 family Pkinase PF00069.25 CCF50343.1 - 2.5e-72 243.4 0.0 3.4e-72 243.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF50343.1 - 1.8e-30 106.1 0.0 2.3e-30 105.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCF50343.1 - 3.3e-09 36.5 0.0 5.9e-09 35.6 0.0 1.4 1 1 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 CCF50343.1 - 4.9e-06 25.6 0.1 2.6e-05 23.2 0.0 1.9 2 0 0 2 2 2 1 Fungal protein kinase Kdo PF06293.14 CCF50343.1 - 0.0014 18.0 0.1 0.0031 16.9 0.0 1.5 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CCF50343.1 - 0.0023 17.9 0.0 0.0046 16.9 0.0 1.6 2 0 0 2 2 2 1 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.9 CCF50343.1 - 0.064 12.8 0.0 0.12 11.9 0.0 1.4 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL DOT1 PF08123.13 CCF50344.1 - 2.9e-55 187.0 0.0 4e-55 186.5 0.0 1.2 1 0 0 1 1 1 1 Histone methylation protein DOT1 Lactamase_B_2 PF12706.7 CCF50344.1 - 0.0032 17.0 0.0 0.006 16.1 0.0 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Mito_carr PF00153.27 CCF50345.1 - 9e-44 147.3 2.6 2.9e-16 59.2 0.3 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein DIE2_ALG10 PF04922.12 CCF50346.1 - 2.7e-89 300.2 3.1 2.6e-71 241.0 1.0 2.6 2 1 0 2 2 2 2 DIE2/ALG10 family DHHC PF01529.20 CCF50346.1 - 5.6 7.1 6.3 1.6 8.8 1.8 2.2 2 0 0 2 2 2 0 DHHC palmitoyltransferase Cu-oxidase_3 PF07732.15 CCF50347.1 - 1.3e-27 96.2 0.1 1.6e-26 92.7 0.1 2.6 2 0 0 2 2 2 1 Multicopper oxidase Cu-oxidase PF00394.22 CCF50347.1 - 1.2e-20 74.3 0.0 6.7e-18 65.3 0.0 2.8 2 1 0 2 2 2 2 Multicopper oxidase Cu-oxidase_2 PF07731.14 CCF50347.1 - 2e-15 56.8 9.7 1.2e-13 50.9 2.0 4.2 2 2 0 2 2 2 1 Multicopper oxidase Monooxygenase_B PF04744.12 CCF50347.1 - 0.17 10.7 0.1 0.31 9.9 0.1 1.3 1 0 0 1 1 1 0 Monooxygenase subunit B protein NAD_binding_5 PF07994.12 CCF50348.1 - 4.6e-144 479.7 0.0 5.5e-144 479.5 0.0 1.1 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase Inos-1-P_synth PF01658.17 CCF50348.1 - 5.1e-43 145.8 0.1 9.3e-43 144.9 0.1 1.5 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase HOOK PF05622.12 CCF50349.1 - 1e-52 179.3 57.7 1e-52 179.3 57.7 2.8 1 1 1 2 2 2 1 HOOK protein DUF3584 PF12128.8 CCF50349.1 - 0.00066 17.4 46.7 0.00066 17.4 46.7 2.6 1 1 2 3 3 3 1 Protein of unknown function (DUF3584) Sec20 PF03908.13 CCF50349.1 - 0.042 13.8 14.4 0.31 11.0 3.5 4.2 3 2 0 3 3 3 0 Sec20 DUF4108 PF13390.6 CCF50349.1 - 0.5 10.3 10.0 15 5.5 5.8 3.2 2 1 0 3 3 3 0 Protein of unknown function (DUF4108) Vip3A_N PF12495.8 CCF50349.1 - 7.4 6.4 8.4 1.2 9.0 2.3 2.7 2 2 0 2 2 2 0 Vegetative insecticide protein 3A N terminal SIKE PF05769.11 CCF50350.1 - 0.002 18.1 13.6 0.0046 16.9 6.7 2.6 2 0 0 2 2 2 2 SIKE family XPG_I_2 PF12813.7 CCF50350.1 - 1.9 7.9 8.4 0.36 10.3 4.5 1.7 2 0 0 2 2 2 0 XPG domain containing TRAPP PF04051.16 CCF50351.1 - 2.8e-18 66.0 0.0 4.1e-18 65.5 0.0 1.2 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component Methyltransf_23 PF13489.6 CCF50352.1 - 6e-15 55.5 0.1 1.4e-14 54.3 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF50352.1 - 1.3e-11 45.1 0.0 3e-11 43.9 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF50352.1 - 3e-07 31.0 0.0 1.1e-06 29.2 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CCF50352.1 - 9.9e-06 25.2 0.0 1.7e-05 24.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_11 PF08241.12 CCF50352.1 - 0.00024 21.7 0.0 0.0014 19.3 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF50352.1 - 0.0049 16.7 0.0 0.02 14.7 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain TPMT PF05724.11 CCF50352.1 - 0.12 12.0 0.0 0.24 11.0 0.0 1.4 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) SR-25 PF10500.9 CCF50352.1 - 1.9 8.0 11.7 2.9 7.5 11.7 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Arf PF00025.21 CCF50353.1 - 5.8e-64 214.7 0.0 6.6e-64 214.5 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 CCF50353.1 - 4.9e-14 52.2 0.0 6e-14 51.9 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.13 CCF50353.1 - 1.1e-13 51.5 0.1 1.6e-13 50.9 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 CCF50353.1 - 1.9e-12 47.1 0.0 2.3e-12 46.8 0.0 1.0 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 CCF50353.1 - 2.1e-11 43.6 0.8 5e-09 35.8 0.1 2.2 1 1 1 2 2 2 2 G-protein alpha subunit MMR_HSR1 PF01926.23 CCF50353.1 - 1.6e-09 37.9 0.0 2.1e-09 37.4 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 CCF50353.1 - 3.9e-07 29.7 0.0 4.8e-07 29.4 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 CCF50353.1 - 1.5e-06 27.9 0.0 0.00028 20.5 0.0 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 CCF50353.1 - 0.0014 18.2 0.4 0.0051 16.3 0.2 1.9 1 1 1 2 2 2 1 Ferrous iron transport protein B IES5 PF17335.2 CCF50353.1 - 0.037 14.3 0.0 0.061 13.6 0.0 1.3 1 0 0 1 1 1 0 Ino80 complex subunit 5 AAA_24 PF13479.6 CCF50353.1 - 0.1 12.3 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain Mannosyl_trans2 PF04188.13 CCF50354.1 - 1.7e-61 208.9 12.4 2.1e-61 208.6 12.4 1.0 1 0 0 1 1 1 1 Mannosyltransferase (PIG-V) DUF4239 PF14023.6 CCF50354.1 - 0.68 9.6 4.3 0.22 11.2 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4239) Gly-zipper_Omp PF13488.6 CCF50355.1 - 2.3 8.3 16.9 9.4 6.3 0.6 2.8 2 1 0 2 2 2 0 Glycine zipper LSM14 PF12701.7 CCF50356.1 - 2.7e-29 101.1 0.0 4.2e-29 100.5 0.0 1.3 1 0 0 1 1 1 1 Scd6-like Sm domain FDF PF09532.10 CCF50356.1 - 1.3e-07 32.4 1.7 0.0048 17.8 0.5 2.6 2 0 0 2 2 2 2 FDF domain SM-ATX PF14438.6 CCF50356.1 - 9.2e-07 28.9 0.0 1.7e-06 28.1 0.0 1.4 1 0 0 1 1 1 1 Ataxin 2 SM domain Bromodomain PF00439.25 CCF50357.1 - 1.1e-19 70.3 0.0 2.7e-19 69.0 0.0 1.7 1 0 0 1 1 1 1 Bromodomain BAH PF01426.18 CCF50357.1 - 1.4e-12 47.5 0.2 2.6e-12 46.7 0.2 1.5 1 0 0 1 1 1 1 BAH domain SUIM_assoc PF16619.5 CCF50357.1 - 1.9e-07 31.0 0.0 0.00066 19.7 0.0 3.9 3 1 0 3 3 3 1 Unstructured region C-term to UIM in Ataxin3 Lon_C PF05362.13 CCF50358.1 - 1.6e-68 230.3 0.0 2.6e-68 229.6 0.0 1.3 1 0 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain AAA PF00004.29 CCF50358.1 - 5.4e-23 81.9 0.0 1.2e-22 80.8 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) LON_substr_bdg PF02190.16 CCF50358.1 - 1.2e-12 48.2 0.0 2.3e-12 47.3 0.0 1.5 1 1 0 1 1 1 1 ATP-dependent protease La (LON) substrate-binding domain AAA_5 PF07728.14 CCF50358.1 - 1.3e-10 41.4 0.0 3.9e-10 39.9 0.0 1.9 2 0 0 2 2 1 1 AAA domain (dynein-related subfamily) ChlI PF13541.6 CCF50358.1 - 8.8e-08 32.0 0.0 1.7e-07 31.1 0.0 1.5 1 0 0 1 1 1 1 Subunit ChlI of Mg-chelatase AAA_22 PF13401.6 CCF50358.1 - 5.7e-05 23.4 0.3 0.0074 16.6 0.0 3.4 2 1 0 2 2 2 1 AAA domain AAA_18 PF13238.6 CCF50358.1 - 9.3e-05 23.0 0.9 0.04 14.5 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 CCF50358.1 - 0.00012 22.5 1.9 0.00023 21.6 0.1 2.5 3 0 0 3 3 1 1 AAA ATPase domain AAA_2 PF07724.14 CCF50358.1 - 0.00012 22.2 0.0 0.00053 20.1 0.0 2.0 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_33 PF13671.6 CCF50358.1 - 0.0083 16.3 0.1 0.03 14.5 0.0 2.0 2 0 0 2 2 1 1 AAA domain Mg_chelatase PF01078.21 CCF50358.1 - 0.0092 15.4 0.1 0.025 14.0 0.0 1.7 2 0 0 2 2 1 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 CCF50358.1 - 0.0096 15.8 0.0 0.023 14.6 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 CCF50358.1 - 0.01 15.6 0.0 0.047 13.4 0.0 2.1 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain TniB PF05621.11 CCF50358.1 - 0.013 14.9 0.0 4.2 6.7 0.0 3.5 4 0 0 4 4 4 0 Bacterial TniB protein RNA_helicase PF00910.22 CCF50358.1 - 0.026 14.9 0.0 0.065 13.6 0.0 1.7 1 0 0 1 1 1 0 RNA helicase AAA_7 PF12775.7 CCF50358.1 - 0.045 13.3 0.0 0.08 12.5 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_25 PF13481.6 CCF50358.1 - 0.049 13.2 0.0 0.13 11.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_PrkA PF08298.11 CCF50358.1 - 0.051 12.5 0.0 0.45 9.4 0.0 2.0 2 0 0 2 2 2 0 PrkA AAA domain ATPase PF06745.13 CCF50358.1 - 0.061 12.7 0.0 25 4.1 0.0 3.2 3 0 0 3 3 3 0 KaiC IstB_IS21 PF01695.17 CCF50358.1 - 0.07 12.9 0.0 0.15 11.8 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_30 PF13604.6 CCF50358.1 - 0.074 12.8 0.0 0.16 11.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain TIP49 PF06068.13 CCF50358.1 - 0.077 12.2 0.0 0.14 11.3 0.0 1.3 1 0 0 1 1 1 0 TIP49 P-loop domain AAA_24 PF13479.6 CCF50358.1 - 0.091 12.5 0.0 0.16 11.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain KTI12 PF08433.10 CCF50358.1 - 0.1 12.0 0.0 0.22 11.0 0.0 1.5 1 0 0 1 1 1 0 Chromatin associated protein KTI12 SinI PF08671.10 CCF50358.1 - 0.13 12.1 0.1 0.46 10.3 0.1 2.0 2 0 0 2 2 2 0 Anti-repressor SinI NACHT PF05729.12 CCF50358.1 - 0.16 11.9 0.0 0.43 10.5 0.0 1.7 1 0 0 1 1 1 0 NACHT domain Rad17 PF03215.15 CCF50358.1 - 0.17 11.8 0.0 0.33 10.9 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_11 PF13086.6 CCF50358.1 - 1.7 8.3 6.1 0.27 11.0 0.1 2.2 1 1 1 2 2 2 0 AAA domain eIF-5_eIF-2B PF01873.17 CCF50359.1 - 1.2e-39 134.9 0.0 2.1e-39 134.0 0.0 1.4 1 0 0 1 1 1 1 Domain found in IF2B/IF5 W2 PF02020.18 CCF50359.1 - 1.4e-19 70.0 0.0 1.4e-19 70.0 0.0 3.2 4 0 0 4 4 4 1 eIF4-gamma/eIF5/eIF2-epsilon Sigma70_ner PF04546.13 CCF50359.1 - 0.0042 17.0 0.0 22 4.9 5.5 2.8 2 1 0 2 2 2 1 Sigma-70, non-essential region DNA_RNApol_7kD PF03604.13 CCF50359.1 - 0.23 11.2 2.1 0.59 9.9 2.1 1.7 1 0 0 1 1 1 0 DNA directed RNA polymerase, 7 kDa subunit PBP1_TM PF14812.6 CCF50359.1 - 0.24 11.8 7.9 0.54 10.7 3.4 3.0 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Cwf_Cwc_15 PF04889.12 CCF50359.1 - 7 6.3 21.4 1.3 8.8 0.4 2.4 2 1 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein Myb_DNA-bind_5 PF13873.6 CCF50361.1 - 0.0025 17.8 2.7 0.0071 16.4 0.7 2.4 2 1 1 3 3 3 1 Myb/SANT-like DNA-binding domain DDE_Tnp_4 PF13359.6 CCF50362.1 - 2.4e-13 50.0 0.0 8.8e-12 45.0 0.0 2.2 2 0 0 2 2 2 2 DDE superfamily endonuclease MAPEG PF01124.18 CCF50363.1 - 1.1e-19 70.7 3.4 1.5e-19 70.1 3.4 1.2 1 0 0 1 1 1 1 MAPEG family Ferritin_2 PF13668.6 CCF50364.1 - 5.7e-39 133.4 0.1 1.1e-38 132.5 0.1 1.4 1 0 0 1 1 1 1 Ferritin-like domain Cullin PF00888.22 CCF50365.1 - 1.2e-169 565.9 3.8 1.7e-169 565.4 3.8 1.2 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 CCF50365.1 - 9.9e-23 80.0 2.5 2.8e-22 78.5 2.5 1.9 1 0 0 1 1 1 1 Cullin protein neddylation domain DUF913 PF06025.12 CCF50366.1 - 6.2e-100 334.7 0.0 6.2e-100 334.7 0.0 7.2 6 2 0 6 6 6 2 Domain of Unknown Function (DUF913) DUF908 PF06012.12 CCF50366.1 - 1.8e-98 330.3 3.5 1.8e-98 330.3 3.5 6.4 7 1 2 9 9 9 1 Domain of Unknown Function (DUF908) UBM PF14377.6 CCF50366.1 - 7.7e-19 66.5 8.0 2.3e-11 42.7 0.9 3.0 2 0 0 2 2 2 2 Ubiquitin binding region UBA PF00627.31 CCF50366.1 - 2e-12 46.7 0.2 8.5e-12 44.7 0.1 2.2 2 0 0 2 2 2 1 UBA/TS-N domain Atg14 PF10186.9 CCF50366.1 - 0.42 9.6 6.2 1 8.4 6.2 1.6 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DLP_helical PF18709.1 CCF50366.1 - 0.52 9.5 3.4 1.1 8.4 3.4 1.5 1 0 0 1 1 1 0 Dynamin-like helical domain GrpE PF01025.19 CCF50366.1 - 1.6 8.3 7.3 5.1 6.7 7.3 1.8 1 0 0 1 1 1 0 GrpE PDEase_II PF02112.15 CCF50368.1 - 5.2e-37 127.7 4.2 1.2e-22 80.5 0.0 3.5 4 0 0 4 4 4 2 cAMP phosphodiesterases class-II Lactamase_B_2 PF12706.7 CCF50368.1 - 0.0013 18.3 0.0 0.0038 16.8 0.0 1.7 2 0 0 2 2 2 1 Beta-lactamase superfamily domain NPR1_interact PF15699.5 CCF50368.1 - 0.41 11.3 3.6 1.2 9.8 3.6 1.8 1 0 0 1 1 1 0 NPR1 interacting Zip PF02535.22 CCF50368.1 - 0.42 9.8 5.0 0.91 8.7 5.0 1.6 1 0 0 1 1 1 0 ZIP Zinc transporter NPR3 PF03666.13 CCF50368.1 - 6.5 5.4 12.0 15 4.3 12.0 1.6 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 OPT PF03169.15 CCF50369.1 - 1.1e-177 592.5 51.4 1.2e-177 592.3 51.4 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein HEAT PF02985.22 CCF50370.1 - 2.4e-15 55.3 14.1 0.0068 16.6 0.0 10.6 10 0 0 10 10 10 4 HEAT repeat HEAT_2 PF13646.6 CCF50370.1 - 1.2e-09 38.4 6.7 9.2e-05 22.8 0.1 4.8 4 1 0 4 4 4 3 HEAT repeats Cnd1 PF12717.7 CCF50370.1 - 2.4e-06 27.7 0.3 0.012 15.7 0.0 3.6 3 1 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 CCF50370.1 - 0.00055 18.6 0.3 0.017 13.7 0.0 2.5 3 0 0 3 3 3 1 Adaptin N terminal region Atg8 PF02991.16 CCF50371.1 - 5.6e-52 174.3 0.1 6.5e-52 174.1 0.1 1.0 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like APG12 PF04110.13 CCF50371.1 - 8.2e-07 29.3 0.0 1e-06 29.0 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 SPT16 PF08644.11 CCF50372.1 - 2.8e-56 189.9 0.5 7.1e-56 188.6 0.0 2.1 2 0 0 2 2 2 1 FACT complex subunit (SPT16/CDC68) FACT-Spt16_Nlob PF14826.6 CCF50372.1 - 1.6e-51 174.3 1.3 4.7e-51 172.8 1.3 1.9 1 0 0 1 1 1 1 FACT complex subunit SPT16 N-terminal lobe domain Peptidase_M24 PF00557.24 CCF50372.1 - 8.8e-29 100.7 0.0 1.7e-28 99.8 0.0 1.4 1 0 0 1 1 1 1 Metallopeptidase family M24 Rtt106 PF08512.12 CCF50372.1 - 8.1e-17 61.4 0.2 5.5e-15 55.6 0.1 2.6 2 0 0 2 2 2 1 Histone chaperone Rttp106-like DUF1378 PF07125.11 CCF50372.1 - 0.0018 18.4 0.1 0.0044 17.1 0.1 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1378) DNA_pol_phi PF04931.13 CCF50372.1 - 3.1 5.8 21.9 6.9 4.6 21.9 1.5 1 0 0 1 1 1 0 DNA polymerase phi DNA_binding_1 PF01035.20 CCF50373.1 - 2.2e-23 82.1 0.1 4.6e-23 81.1 0.0 1.5 2 0 0 2 2 2 1 6-O-methylguanine DNA methyltransferase, DNA binding domain Prion PF00377.18 CCF50373.1 - 0.0076 16.1 0.0 0.013 15.4 0.0 1.3 1 0 0 1 1 1 1 Prion/Doppel alpha-helical domain UPF0126 PF03458.13 CCF50374.1 - 0.85 9.5 8.1 3.9 7.4 0.6 2.9 3 0 0 3 3 3 0 UPF0126 domain Hydrolase_4 PF12146.8 CCF50375.1 - 1.3e-13 50.8 0.0 2e-13 50.2 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 CCF50375.1 - 1.3e-13 51.2 0.1 2.3e-10 40.6 0.0 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CCF50375.1 - 4.6e-11 43.8 0.0 5.9e-11 43.4 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Thioesterase PF00975.20 CCF50375.1 - 0.0046 17.1 0.0 0.014 15.5 0.0 1.7 2 0 0 2 2 2 1 Thioesterase domain Peptidase_S9 PF00326.21 CCF50375.1 - 0.012 15.0 0.1 0.31 10.5 0.0 2.1 2 0 0 2 2 2 0 Prolyl oligopeptidase family DLH PF01738.18 CCF50375.1 - 0.022 14.3 0.0 0.79 9.2 0.0 2.1 2 0 0 2 2 2 0 Dienelactone hydrolase family Esterase PF00756.20 CCF50375.1 - 0.031 13.9 0.1 0.067 12.8 0.1 1.7 1 1 0 1 1 1 0 Putative esterase Esterase_phd PF10503.9 CCF50375.1 - 0.082 12.4 0.0 2.8 7.4 0.0 2.3 2 0 0 2 2 2 0 Esterase PHB depolymerase AAA PF00004.29 CCF50376.1 - 2.1e-32 112.3 0.1 3.5e-32 111.6 0.1 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 CCF50376.1 - 2.2e-07 31.2 0.2 1e-06 29.1 0.2 2.0 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CCF50376.1 - 2e-06 28.3 0.0 6.4e-06 26.7 0.0 1.8 2 0 0 2 2 1 1 AAA ATPase domain AAA_2 PF07724.14 CCF50376.1 - 2.6e-05 24.4 0.0 6.2e-05 23.2 0.0 1.6 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_18 PF13238.6 CCF50376.1 - 2.6e-05 24.8 0.0 5e-05 23.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 CCF50376.1 - 2.9e-05 24.3 0.1 9.2e-05 22.6 0.1 1.9 1 1 0 1 1 1 1 AAA domain AAA_14 PF13173.6 CCF50376.1 - 0.00029 20.9 0.0 0.00054 20.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain NACHT PF05729.12 CCF50376.1 - 0.00043 20.2 0.3 0.0031 17.4 0.3 2.1 1 1 0 1 1 1 1 NACHT domain ATPase_2 PF01637.18 CCF50376.1 - 0.00044 20.2 0.3 0.16 11.8 0.3 2.3 1 1 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_24 PF13479.6 CCF50376.1 - 0.00061 19.6 0.0 0.0015 18.3 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_25 PF13481.6 CCF50376.1 - 0.001 18.7 3.5 0.17 11.4 0.1 2.7 2 1 1 3 3 3 2 AAA domain RNA_helicase PF00910.22 CCF50376.1 - 0.0014 19.0 0.0 0.0038 17.6 0.0 1.7 1 0 0 1 1 1 1 RNA helicase AAA_30 PF13604.6 CCF50376.1 - 0.0016 18.2 0.9 0.0077 16.0 0.0 2.5 3 1 0 3 3 2 1 AAA domain DUF815 PF05673.13 CCF50376.1 - 0.0018 17.5 0.3 0.014 14.6 0.3 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF815) RuvB_N PF05496.12 CCF50376.1 - 0.002 17.9 0.1 0.0054 16.5 0.1 1.7 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 CCF50376.1 - 0.0025 17.8 0.4 0.0079 16.2 0.4 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_11 PF13086.6 CCF50376.1 - 0.0027 17.6 0.1 0.0067 16.2 0.1 1.8 1 1 0 1 1 1 1 AAA domain Cytidylate_kin PF02224.18 CCF50376.1 - 0.0037 17.0 0.6 0.008 15.9 0.1 1.9 2 1 0 2 2 1 1 Cytidylate kinase TsaE PF02367.17 CCF50376.1 - 0.004 17.1 0.0 0.0078 16.2 0.0 1.4 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE Viral_helicase1 PF01443.18 CCF50376.1 - 0.0049 16.6 0.1 0.017 14.8 0.0 1.9 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase IstB_IS21 PF01695.17 CCF50376.1 - 0.0051 16.6 0.0 0.012 15.3 0.0 1.7 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_28 PF13521.6 CCF50376.1 - 0.0055 17.0 0.0 0.01 16.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain TIP49 PF06068.13 CCF50376.1 - 0.0065 15.7 0.0 0.0094 15.2 0.0 1.2 1 0 0 1 1 1 1 TIP49 P-loop domain ABC_tran PF00005.27 CCF50376.1 - 0.0085 16.6 0.0 0.02 15.4 0.0 1.7 2 0 0 2 2 1 1 ABC transporter AAA_7 PF12775.7 CCF50376.1 - 0.015 14.8 0.0 0.034 13.7 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region Rad17 PF03215.15 CCF50376.1 - 0.017 15.0 0.1 0.053 13.4 0.1 1.7 1 1 1 2 2 1 0 Rad17 P-loop domain KAP_NTPase PF07693.14 CCF50376.1 - 0.021 14.0 0.1 5.1 6.2 0.0 2.2 1 1 1 2 2 2 0 KAP family P-loop domain AAA_17 PF13207.6 CCF50376.1 - 0.025 15.0 0.0 0.06 13.8 0.0 1.6 1 1 0 1 1 1 0 AAA domain AAA_19 PF13245.6 CCF50376.1 - 0.033 14.5 2.5 0.18 12.2 0.1 3.0 2 1 2 4 4 4 0 AAA domain DUF2075 PF09848.9 CCF50376.1 - 0.035 13.4 0.0 0.052 12.8 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Mg_chelatase PF01078.21 CCF50376.1 - 0.039 13.3 0.0 0.099 12.0 0.0 1.7 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI ATPase PF06745.13 CCF50376.1 - 0.048 13.0 0.3 1.1 8.5 0.0 2.2 1 1 1 2 2 2 0 KaiC PduV-EutP PF10662.9 CCF50376.1 - 0.079 12.7 0.0 0.13 12.0 0.0 1.5 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation PhoH PF02562.16 CCF50376.1 - 0.09 12.2 0.1 0.41 10.1 0.0 1.9 2 0 0 2 2 2 0 PhoH-like protein AAA_23 PF13476.6 CCF50376.1 - 0.099 13.1 0.0 0.12 12.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain Rad51 PF08423.11 CCF50376.1 - 0.1 11.8 0.3 6.6 5.9 0.3 2.2 1 1 1 2 2 2 0 Rad51 AAA_3 PF07726.11 CCF50376.1 - 0.11 12.3 0.0 0.29 11.0 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_13 PF13166.6 CCF50376.1 - 0.13 10.9 0.0 0.24 10.0 0.0 1.3 1 1 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 CCF50376.1 - 0.15 12.0 0.1 0.78 9.6 0.0 2.0 2 0 0 2 2 2 0 NTPase AAA_6 PF12774.7 CCF50376.1 - 0.17 10.8 0.0 0.35 9.8 0.0 1.4 1 1 0 1 1 1 0 Hydrolytic ATP binding site of dynein motor region Cyclin PF08613.11 CCF50377.1 - 7.1e-12 46.0 0.9 1.5e-11 44.9 0.1 2.0 2 1 0 2 2 2 1 Cyclin Cyclin_N PF00134.23 CCF50377.1 - 8.5e-07 28.8 0.0 1.5e-06 28.0 0.0 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain ANAPC4_WD40 PF12894.7 CCF50378.1 - 8.7e-07 29.2 0.0 0.015 15.6 0.0 3.5 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 CCF50378.1 - 4.1e-05 24.3 13.1 0.15 12.9 2.7 5.6 5 1 1 6 6 6 2 WD domain, G-beta repeat DUF2415 PF10313.9 CCF50378.1 - 0.00011 22.1 0.0 0.00028 20.7 0.0 1.7 1 0 0 1 1 1 1 Uncharacterised protein domain (DUF2415) Ge1_WD40 PF16529.5 CCF50378.1 - 0.018 14.0 0.1 0.062 12.3 0.1 1.7 1 1 1 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 CCF50378.1 - 1.1 9.3 6.7 0.41 10.6 0.4 3.4 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat zf-HC5HC2H_2 PF13832.6 CCF50379.1 - 2.3e-20 72.8 27.0 4.7e-20 71.8 4.8 4.1 4 0 0 4 4 4 2 PHD-zinc-finger like domain PHD PF00628.29 CCF50379.1 - 5.2e-15 55.1 23.7 3.6e-10 39.6 6.2 5.8 6 1 0 6 6 6 2 PHD-finger zf-HC5HC2H PF13771.6 CCF50379.1 - 6.8e-15 55.1 7.0 6.8e-15 55.1 7.0 4.8 5 0 0 5 5 5 2 PHD-like zinc-binding domain BAH PF01426.18 CCF50379.1 - 1.3e-08 34.8 0.0 2.4e-08 33.8 0.0 1.4 1 0 0 1 1 1 1 BAH domain PHD_2 PF13831.6 CCF50379.1 - 4.7e-08 32.4 4.3 4.7e-08 32.4 4.3 5.0 7 0 0 7 7 7 2 PHD-finger GATA PF00320.27 CCF50379.1 - 6.5e-07 28.8 9.7 3.3e-06 26.6 1.7 3.4 2 0 0 2 2 2 2 GATA zinc finger ELM2 PF01448.24 CCF50379.1 - 0.0026 18.5 0.0 0.0087 16.8 0.0 2.0 1 1 0 1 1 1 1 ELM2 domain bZIP_1 PF00170.21 CCF50380.1 - 1.3e-05 25.1 6.1 1.3e-05 25.1 6.1 2.6 3 0 0 3 3 3 1 bZIP transcription factor EndoU_bacteria PF14436.6 CCF50380.1 - 0.015 15.6 3.7 0.019 15.3 1.9 2.2 1 1 1 2 2 2 0 Bacterial EndoU nuclease bZIP_2 PF07716.15 CCF50380.1 - 0.22 11.6 9.8 1 9.5 8.4 2.6 1 1 1 2 2 2 0 Basic region leucine zipper DUF488 PF04343.13 CCF50380.1 - 0.66 10.6 4.5 5.3 7.6 4.3 2.3 1 1 1 2 2 2 0 Protein of unknown function, DUF488 TFIIA PF03153.13 CCF50380.1 - 8 6.3 41.6 1.1 9.1 35.7 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit SPRY PF00622.28 CCF50381.1 - 5.2e-22 78.2 0.1 1.3e-21 76.9 0.1 1.7 1 0 0 1 1 1 1 SPRY domain Arf PF00025.21 CCF50382.1 - 2.1e-77 258.5 0.0 2.4e-77 258.3 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 CCF50382.1 - 2.9e-15 56.5 0.0 3.9e-15 56.1 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 CCF50382.1 - 1.3e-12 47.7 0.0 1.4e-12 47.5 0.0 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 CCF50382.1 - 2.4e-11 43.4 0.8 6.8e-07 28.8 0.1 2.2 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.10 CCF50382.1 - 1.1e-10 41.2 0.0 1.4e-10 40.9 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 CCF50382.1 - 3.7e-09 36.3 0.0 4.7e-09 36.0 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 CCF50382.1 - 0.00022 21.3 0.0 0.00037 20.6 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.18 CCF50382.1 - 0.0016 17.8 0.1 0.0024 17.2 0.1 1.2 1 0 0 1 1 1 1 6-phosphofructo-2-kinase Cys_Met_Meta_PP PF01053.20 CCF50383.1 - 6.4e-148 492.4 0.0 7.2e-148 492.2 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 CCF50383.1 - 2.3e-10 40.0 0.2 3.9e-10 39.2 0.2 1.3 1 0 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 CCF50383.1 - 9e-09 35.1 0.1 1.4e-08 34.4 0.1 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_1_2 PF00155.21 CCF50383.1 - 2.5e-07 30.2 0.1 3.9e-07 29.6 0.1 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 CCF50383.1 - 0.00047 19.5 0.0 0.00084 18.7 0.0 1.4 1 0 0 1 1 1 1 Beta-eliminating lyase Met_gamma_lyase PF06838.11 CCF50383.1 - 0.00094 17.8 0.0 0.0012 17.4 0.0 1.2 1 0 0 1 1 1 1 Methionine gamma-lyase UDPGP PF01704.18 CCF50385.1 - 1.9e-200 665.8 0.3 2.1e-200 665.6 0.3 1.0 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase RRM_1 PF00076.22 CCF50386.1 - 6.5e-11 41.9 0.0 7.2e-07 28.9 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 CCF50386.1 - 0.0089 16.1 0.3 1.3 9.1 0.0 2.8 2 1 1 3 3 3 2 RNA binding motif FmiP_Thoc5 PF09766.9 CCF50386.1 - 0.017 14.4 1.0 0.021 14.2 1.0 1.1 1 0 0 1 1 1 0 Fms-interacting protein/Thoc5 Dioxygenase_C PF00775.21 CCF50387.1 - 4.1e-42 143.7 0.0 6.2e-42 143.1 0.0 1.3 1 0 0 1 1 1 1 Dioxygenase Dioxygenase_N PF04444.14 CCF50387.1 - 5.6e-27 93.4 0.0 9.1e-27 92.7 0.0 1.3 1 0 0 1 1 1 1 Catechol dioxygenase N terminus CarboxypepD_reg PF13620.6 CCF50387.1 - 1.3e-06 28.6 0.0 3.6e-06 27.1 0.0 1.7 1 0 0 1 1 1 1 Carboxypeptidase regulatory-like domain CarbopepD_reg_2 PF13715.6 CCF50387.1 - 0.018 15.0 0.1 10 6.2 0.0 2.5 2 0 0 2 2 2 0 CarboxypepD_reg-like domain Mito_carr PF00153.27 CCF50389.1 - 1.6e-62 207.4 6.8 9.1e-21 73.6 0.2 3.8 3 1 0 3 3 3 3 Mitochondrial carrier protein adh_short PF00106.25 CCF50391.1 - 1.4e-35 122.6 0.5 9.3e-17 61.1 0.1 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CCF50391.1 - 4.3e-35 121.4 0.2 5.3e-24 85.1 0.0 2.0 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF50391.1 - 4.2e-05 23.5 1.5 0.00038 20.4 0.2 2.3 2 1 0 2 2 2 1 KR domain Pyr_redox PF00070.27 CCF50391.1 - 0.016 15.8 0.6 0.063 13.8 0.7 1.9 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_7 PF13241.6 CCF50391.1 - 0.024 15.1 0.0 0.045 14.2 0.0 1.5 1 0 0 1 1 1 0 Putative NAD(P)-binding DUF1776 PF08643.10 CCF50391.1 - 0.063 12.6 0.0 0.09 12.1 0.0 1.2 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) AAA_5 PF07728.14 CCF50393.1 - 2.4e-61 205.8 0.0 1.6e-25 89.7 0.0 3.4 3 0 0 3 3 3 3 AAA domain (dynein-related subfamily) DUF1967 PF09269.11 CCF50393.1 - 0.15 12.0 0.0 0.4 10.7 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1967) MCM PF00493.23 CCF50393.1 - 0.21 10.6 0.0 0.47 9.5 0.0 1.5 1 0 0 1 1 1 0 MCM P-loop domain DUF3179 PF11376.8 CCF50394.1 - 0.079 12.3 0.1 0.17 11.2 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3179) Response_reg PF00072.24 CCF50395.1 - 3.1e-24 85.3 0.2 1.3e-16 60.8 0.1 2.3 1 1 0 2 2 2 2 Response regulator receiver domain DUF202 PF02656.15 CCF50396.1 - 2.7e-13 50.1 4.9 2.7e-13 50.1 4.9 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF202) COX2_TM PF02790.15 CCF50396.1 - 0.016 15.3 0.6 0.16 12.1 0.0 2.0 2 0 0 2 2 2 0 Cytochrome C oxidase subunit II, transmembrane domain DUF3429 PF11911.8 CCF50397.1 - 3.8e-39 134.3 13.6 3.8e-39 134.3 13.6 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF3429) DDHD PF02862.17 CCF50397.1 - 0.2 11.8 7.7 2.1 8.4 0.1 2.1 2 0 0 2 2 2 0 DDHD domain COX14 PF14880.6 CCF50398.1 - 0.0024 17.7 0.3 0.004 17.0 0.3 1.3 1 0 0 1 1 1 1 Cytochrome oxidase c assembly PPR_2 PF13041.6 CCF50399.1 - 3.1e-13 49.7 0.0 1.8e-12 47.2 0.0 2.4 2 0 0 2 2 2 1 PPR repeat family PPR PF01535.20 CCF50399.1 - 8.7e-07 28.8 0.3 0.0068 16.6 0.0 3.7 3 0 0 3 3 3 2 PPR repeat PPR_3 PF13812.6 CCF50399.1 - 3.9e-05 23.6 0.0 8.1e-05 22.6 0.0 1.5 1 0 0 1 1 1 1 Pentatricopeptide repeat domain PPR_1 PF12854.7 CCF50399.1 - 6.6e-05 22.5 0.0 0.2 11.4 0.0 2.7 2 0 0 2 2 2 2 PPR repeat FliN_N PF16973.5 CCF50399.1 - 4.8 7.1 6.3 4 7.4 0.4 3.6 3 0 0 3 3 3 0 Flagellar motor switch protein FliN N-terminal CHCH PF06747.13 CCF50400.1 - 3.5e-06 27.0 6.7 3.5e-06 27.0 6.7 2.3 2 0 0 2 2 2 1 CHCH domain CX9C PF16860.5 CCF50400.1 - 0.00018 21.4 10.7 0.0065 16.4 5.3 2.3 2 0 0 2 2 2 2 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, Pet191_N PF10203.9 CCF50400.1 - 0.17 12.2 11.0 7.1 7.0 0.2 2.9 1 1 1 2 2 2 0 Cytochrome c oxidase assembly protein PET191 Iso_dh PF00180.20 CCF50401.1 - 5.5e-98 328.3 0.0 6.2e-98 328.1 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Aldedh PF00171.22 CCF50402.1 - 1.7e-144 481.8 0.0 2.1e-144 481.5 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.11 CCF50402.1 - 6.7e-05 22.4 0.0 0.00017 21.1 0.1 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF1487) Zn_clus PF00172.18 CCF50403.1 - 0.00035 20.6 10.1 0.00069 19.7 10.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Sugar_tr PF00083.24 CCF50405.1 - 3.9e-104 349.0 20.0 4.7e-104 348.8 20.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF50405.1 - 4e-22 78.6 27.7 4.1e-22 78.6 24.4 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily HD_2 PF12917.7 CCF50406.1 - 0.098 12.4 0.7 0.11 12.3 0.7 1.1 1 0 0 1 1 1 0 HD containing hydrolase-like enzyme SGL PF08450.12 CCF50407.1 - 3.2e-14 53.1 0.4 2.2e-07 30.7 0.1 2.3 2 0 0 2 2 2 2 SMP-30/Gluconolactonase/LRE-like region DUF3404 PF11884.8 CCF50407.1 - 0.05 12.8 0.1 0.076 12.2 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3404) COX2 PF00116.20 CCF50408.1 - 0.046 13.6 0.1 8.3 6.3 0.0 2.1 2 0 0 2 2 2 0 Cytochrome C oxidase subunit II, periplasmic domain 3-HAO PF06052.12 CCF50411.1 - 8.7e-58 194.3 0.0 1.1e-57 193.9 0.0 1.0 1 0 0 1 1 1 1 3-hydroxyanthranilic acid dioxygenase Cupin_2 PF07883.11 CCF50411.1 - 1.7e-06 27.6 0.0 2.7e-06 27.0 0.0 1.3 1 0 0 1 1 1 1 Cupin domain Cupin_1 PF00190.22 CCF50411.1 - 0.0017 18.0 0.0 0.0028 17.3 0.0 1.2 1 0 0 1 1 1 1 Cupin ARD PF03079.14 CCF50411.1 - 0.0065 16.7 0.0 0.0094 16.2 0.0 1.2 1 0 0 1 1 1 1 ARD/ARD' family AraC_binding PF02311.19 CCF50411.1 - 0.13 12.2 0.0 0.2 11.5 0.0 1.3 1 0 0 1 1 1 0 AraC-like ligand binding domain Snf7 PF03357.21 CCF50412.1 - 8e-14 51.6 8.0 1e-13 51.3 8.0 1.2 1 0 0 1 1 1 1 Snf7 Ist1 PF03398.14 CCF50412.1 - 0.0008 19.4 2.6 0.0012 18.7 2.6 1.2 1 0 0 1 1 1 1 Regulator of Vps4 activity in the MVB pathway DMSP_lyase PF16867.5 CCF50412.1 - 0.033 13.8 0.0 0.072 12.7 0.0 1.5 1 0 0 1 1 1 0 Dimethlysulfonioproprionate lyase PspA_IM30 PF04012.12 CCF50412.1 - 2.8 7.4 14.5 2.3e+02 1.2 14.5 2.3 1 1 0 1 1 1 0 PspA/IM30 family zf-U1 PF06220.12 CCF50413.1 - 3.1e-19 68.5 4.2 4.4e-19 68.0 4.2 1.2 1 0 0 1 1 1 1 U1 zinc finger UPF0236 PF06782.11 CCF50413.1 - 0.24 10.0 0.0 0.31 9.6 0.0 1.0 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0236) WD40 PF00400.32 CCF50414.1 - 1.4e-07 32.1 0.1 0.038 14.9 0.0 3.5 3 0 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF50414.1 - 0.058 13.7 0.0 18 5.7 0.0 2.7 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CCF50414.1 - 0.083 11.8 0.4 4 6.3 0.0 2.6 3 0 0 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Aldedh PF00171.22 CCF50415.1 - 5.3e-161 536.2 1.7 6.1e-161 536.0 1.7 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.11 CCF50415.1 - 0.025 14.0 0.0 0.095 12.1 0.0 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1487) EVC2_like PF12297.8 CCF50415.1 - 0.2 10.3 0.0 0.31 9.7 0.0 1.2 1 0 0 1 1 1 0 Ellis van Creveld protein 2 like protein Tam41_Mmp37 PF09139.11 CCF50417.1 - 2.1e-110 369.2 0.0 2.5e-110 368.9 0.0 1.1 1 0 0 1 1 1 1 Phosphatidate cytidylyltransferase, mitochondrial Rrn6 PF10214.9 CCF50417.1 - 0.055 12.0 5.3 0.089 11.3 5.3 1.2 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor HAP1_N PF04849.13 CCF50418.1 - 0.14 11.3 21.7 0.75 8.9 2.1 3.4 2 1 0 3 3 3 0 HAP1 N-terminal conserved region Fzo_mitofusin PF04799.13 CCF50418.1 - 1.9 8.0 10.7 0.73 9.4 5.8 2.5 2 1 1 3 3 3 0 fzo-like conserved region DUF3450 PF11932.8 CCF50418.1 - 3.1 7.0 23.6 0.47 9.7 0.0 3.5 2 1 1 3 3 3 0 Protein of unknown function (DUF3450) DUF4407 PF14362.6 CCF50418.1 - 3.8 6.8 26.1 0.65 9.3 18.2 2.4 1 1 0 2 2 2 0 Domain of unknown function (DUF4407) Baculo_PEP_C PF04513.12 CCF50418.1 - 4.3 7.4 12.4 0.6 10.1 0.1 3.6 3 1 1 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus Spc7 PF08317.11 CCF50418.1 - 4.4 6.1 21.7 24 3.7 0.1 2.4 2 0 0 2 2 2 0 Spc7 kinetochore protein Prominin PF05478.11 CCF50418.1 - 5.2 4.9 8.2 1.1 7.1 0.9 2.1 1 1 1 2 2 2 0 Prominin DivIVA PF05103.13 CCF50418.1 - 5.8 7.0 14.0 1.4 9.0 0.2 3.1 2 1 0 2 2 2 0 DivIVA protein Seryl_tRNA_N PF02403.22 CCF50418.1 - 7.9 6.8 18.3 1.7 8.9 7.5 3.6 2 1 1 3 3 3 0 Seryl-tRNA synthetase N-terminal domain adh_short PF00106.25 CCF50419.1 - 1e-21 77.3 0.0 2.9e-18 66.0 0.1 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CCF50419.1 - 6.3e-10 39.0 0.0 2.7e-08 33.7 0.0 2.1 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 CCF50419.1 - 9e-06 25.3 0.0 1.3e-05 24.7 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family KR PF08659.10 CCF50419.1 - 1.1e-05 25.4 0.0 1.8e-05 24.7 0.0 1.3 1 0 0 1 1 1 1 KR domain GDP_Man_Dehyd PF16363.5 CCF50419.1 - 0.0013 18.2 0.0 0.0044 16.5 0.0 1.7 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 CCF50419.1 - 0.038 13.1 0.0 0.06 12.5 0.0 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein DUF4499 PF14934.6 CCF50420.1 - 0.0013 19.0 0.3 0.0015 18.8 0.3 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4499) HsbA PF12296.8 CCF50421.1 - 3.7e-18 66.1 7.2 8.3e-18 65.0 7.2 1.6 1 0 0 1 1 1 1 Hydrophobic surface binding protein A DUF4107 PF13389.6 CCF50421.1 - 0.27 11.4 1.9 0.58 10.3 0.4 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF4107) Abhydrolase_3 PF07859.13 CCF50422.1 - 1e-46 159.5 0.0 1.3e-46 159.2 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 CCF50422.1 - 3.4e-06 26.2 0.6 1.8e-05 23.8 0.6 1.8 1 1 0 1 1 1 1 Carboxylesterase family Peptidase_S9 PF00326.21 CCF50422.1 - 0.00089 18.8 0.1 0.066 12.7 0.1 2.3 2 0 0 2 2 2 2 Prolyl oligopeptidase family AXE1 PF05448.12 CCF50422.1 - 0.0019 17.0 0.1 0.02 13.6 0.1 2.0 1 1 0 1 1 1 1 Acetyl xylan esterase (AXE1) DLH PF01738.18 CCF50422.1 - 0.037 13.6 0.0 7 6.1 0.0 2.3 2 0 0 2 2 2 0 Dienelactone hydrolase family XLF PF09302.11 CCF50423.1 - 0.0038 17.4 0.2 0.0087 16.2 0.2 1.6 1 1 0 1 1 1 1 XLF-Cernunnos, XRcc4-like factor, NHEJ component ERG4_ERG24 PF01222.17 CCF50424.1 - 8.1e-142 473.0 9.2 9.6e-142 472.7 9.2 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family DUF1295 PF06966.12 CCF50424.1 - 4.2e-07 29.7 0.3 1.2e-06 28.2 0.3 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) PEMT PF04191.13 CCF50424.1 - 0.00041 20.7 0.9 0.0015 18.9 0.0 2.5 3 0 0 3 3 3 1 Phospholipid methyltransferase ICMT PF04140.14 CCF50424.1 - 0.021 15.2 0.0 0.075 13.5 0.0 1.9 1 0 0 1 1 1 0 Isoprenylcysteine carboxyl methyltransferase (ICMT) family ORC6 PF05460.13 CCF50424.1 - 7.7 5.7 10.4 11 5.1 10.4 1.1 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) DUF2012 PF09430.10 CCF50425.1 - 2.1e-36 124.7 0.0 2.9e-36 124.3 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2012) CarboxypepD_reg PF13620.6 CCF50425.1 - 0.069 13.4 0.0 0.16 12.2 0.0 1.7 1 1 0 1 1 1 0 Carboxypeptidase regulatory-like domain Atx10homo_assoc PF09759.9 CCF50426.1 - 2.5e-21 75.6 1.0 4.3e-18 65.2 0.0 4.3 5 0 0 5 5 5 1 Spinocerebellar ataxia type 10 protein domain DUF1858 PF08984.11 CCF50426.1 - 0.038 14.1 0.2 0.51 10.5 0.1 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF1858) RYDR_ITPR PF01365.21 CCF50426.1 - 0.095 12.1 0.2 3.7 6.9 0.1 2.8 2 1 0 2 2 2 0 RIH domain PAN_4 PF14295.6 CCF50427.1 - 0.0055 16.6 0.4 0.022 14.6 0.4 2.0 1 0 0 1 1 1 1 PAN domain Glyco_trans_2_3 PF13632.6 CCF50430.1 - 5.3e-50 170.1 6.6 5.3e-50 170.1 6.6 3.1 3 1 0 3 3 3 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 CCF50430.1 - 4.6e-05 23.4 0.2 0.00021 21.3 0.0 1.9 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 CCF50430.1 - 0.0011 18.8 0.0 0.057 13.2 0.0 2.8 2 0 0 2 2 2 1 Glycosyl transferase family 2 Glyco_transf_21 PF13506.6 CCF50430.1 - 0.0023 17.4 0.0 0.0043 16.6 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 21 TMEM206 PF15122.6 CCF50430.1 - 0.064 12.4 0.6 0.11 11.6 0.6 1.3 1 0 0 1 1 1 0 TMEM206 protein family Glyco_hydro_16 PF00722.21 CCF50431.1 - 2e-15 56.7 1.1 4.3e-15 55.6 1.1 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 MMM1 PF10296.9 CCF50432.1 - 1.6e-81 274.0 0.0 6.9e-81 271.9 0.0 1.8 1 1 0 1 1 1 1 Maintenance of mitochondrial morphology protein 1 Cyt-b5 PF00173.28 CCF50433.1 - 2.3e-20 72.5 3.3 2.9e-20 72.2 0.3 2.3 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain FA_hydroxylase PF04116.13 CCF50433.1 - 5.8e-15 55.8 17.4 2.5e-14 53.8 14.9 2.2 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily Lactamase_B_4 PF13691.6 CCF50434.1 - 2.6e-13 49.4 0.0 7.8e-13 47.9 0.0 1.9 2 0 0 2 2 2 1 tRNase Z endonuclease Lactamase_B_2 PF12706.7 CCF50434.1 - 1.2e-09 38.0 4.3 2.5e-07 30.4 0.7 2.6 1 1 1 2 2 2 2 Beta-lactamase superfamily domain Lactamase_B PF00753.27 CCF50434.1 - 0.012 15.6 1.2 0.036 14.1 1.2 1.8 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily DUF1682 PF07946.14 CCF50437.1 - 0.014 14.6 8.3 0.043 13.0 8.3 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) Acyl-CoA_dh_2 PF08028.11 CCF50438.1 - 0.09 13.0 3.5 0.18 12.1 3.5 1.4 1 0 0 1 1 1 0 Acyl-CoA dehydrogenase, C-terminal domain Ni_hydr_CYTB PF01292.20 CCF50438.1 - 0.15 11.6 2.7 0.66 9.6 2.6 1.9 1 1 1 2 2 2 0 Prokaryotic cytochrome b561 Rot1 PF10681.9 CCF50438.1 - 0.16 11.5 0.0 0.33 10.4 0.0 1.5 1 0 0 1 1 1 0 Chaperone for protein-folding within the ER, fungal PRIMA1 PF16101.5 CCF50438.1 - 9.8 6.2 9.2 1.5 8.9 2.0 2.6 2 1 1 3 3 3 0 Proline-rich membrane anchor 1 Dynamin_N PF00350.23 CCF50439.1 - 9.9e-17 61.5 0.0 7.6e-16 58.6 0.0 2.3 1 1 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.23 CCF50439.1 - 0.13 12.4 0.0 1.1 9.4 0.0 2.2 1 1 0 1 1 1 0 50S ribosome-binding GTPase KCT2 PF17818.1 CCF50439.1 - 0.14 12.2 1.2 1.2 9.3 0.7 2.5 2 0 0 2 2 2 0 Keratinocyte-associated gene product AAA_28 PF13521.6 CCF50439.1 - 0.73 10.1 3.3 0.34 11.1 0.6 1.8 2 0 0 2 2 2 0 AAA domain RCC1_2 PF13540.6 CCF50440.1 - 6.4e-18 64.1 11.7 0.00031 20.4 0.1 6.5 8 0 0 8 8 8 4 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 CCF50440.1 - 2.1e-15 57.1 14.1 0.00052 20.6 0.0 7.5 7 2 0 7 7 7 4 Regulator of chromosome condensation (RCC1) repeat KH_1 PF00013.29 CCF50441.1 - 8.8e-41 137.6 7.6 1.1e-16 60.4 0.2 3.2 3 0 0 3 3 3 3 KH domain KH_2 PF07650.17 CCF50441.1 - 1.6e-11 43.8 6.0 0.0017 18.1 0.2 3.3 3 0 0 3 3 3 3 KH domain KH_4 PF13083.6 CCF50441.1 - 7.4e-09 35.4 1.0 0.015 15.1 0.0 3.5 3 0 0 3 3 3 3 KH domain KH_5 PF13184.6 CCF50441.1 - 0.00017 21.6 3.3 0.082 13.0 0.2 3.6 3 0 0 3 3 3 1 NusA-like KH domain Menin PF05053.13 CCF50441.1 - 4.4 5.6 8.9 6.9 4.9 8.9 1.2 1 0 0 1 1 1 0 Menin DUF202 PF02656.15 CCF50442.1 - 9e-19 67.7 1.3 9e-19 67.7 1.3 2.1 2 1 1 3 3 3 1 Domain of unknown function (DUF202) CTU2 PF10288.9 CCF50443.1 - 0.013 15.7 7.0 0.013 15.7 7.0 3.0 3 0 0 3 3 3 0 Cytoplasmic tRNA 2-thiolation protein 2 CDC45 PF02724.14 CCF50443.1 - 0.014 13.7 6.8 0.031 12.6 6.8 1.6 1 0 0 1 1 1 0 CDC45-like protein MDM10 PF12519.8 CCF50443.1 - 0.039 12.8 7.8 0.074 11.9 7.8 1.4 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 Dynamin_N PF00350.23 CCF50443.1 - 0.04 14.0 2.6 0.087 12.9 2.6 1.5 1 0 0 1 1 1 0 Dynamin family NARP1 PF12569.8 CCF50443.1 - 0.073 12.0 10.1 0.16 10.8 10.1 1.5 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Membralin PF09746.9 CCF50443.1 - 0.086 11.9 4.9 0.15 11.1 4.9 1.3 1 0 0 1 1 1 0 Tumour-associated protein zf-CCHC_6 PF15288.6 CCF50443.1 - 0.095 12.5 1.7 0.51 10.2 1.7 2.3 1 0 0 1 1 1 0 Zinc knuckle SpoIIP PF07454.11 CCF50443.1 - 0.11 12.0 17.3 0.017 14.6 12.8 1.8 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) Otopetrin PF03189.13 CCF50443.1 - 0.19 10.5 4.5 0.26 10.1 4.5 1.3 1 0 0 1 1 1 0 Otopetrin CLN3 PF02487.17 CCF50443.1 - 0.2 10.7 9.9 0.34 9.9 9.9 1.3 1 0 0 1 1 1 0 CLN3 protein Sec62 PF03839.16 CCF50443.1 - 0.52 9.8 11.0 1.5 8.2 11.0 1.7 1 0 0 1 1 1 0 Translocation protein Sec62 zf-C2H2_10 PF16588.5 CCF50443.1 - 1.5 8.6 9.0 0.09 12.5 3.9 1.7 2 0 0 2 2 2 0 C2H2 zinc-finger Connexin PF00029.19 CCF50443.1 - 2.7 7.7 12.8 0.38 10.5 8.3 1.8 2 0 0 2 2 2 0 Connexin Dicty_REP PF05086.12 CCF50443.1 - 4.9 5.0 8.9 6.8 4.5 8.9 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Ndc1_Nup PF09531.10 CCF50443.1 - 5.9 5.4 21.8 0.071 11.8 11.0 2.2 2 0 0 2 2 2 0 Nucleoporin protein Ndc1-Nup PAT1 PF09770.9 CCF50443.1 - 7 4.8 41.1 0.087 11.1 31.1 2.0 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 ALMT PF11744.8 CCF50443.1 - 9.4 4.9 15.9 19 3.9 15.9 1.5 1 0 0 1 1 1 0 Aluminium activated malate transporter Acyltransferase PF01553.21 CCF50444.1 - 0.007 16.0 0.0 0.099 12.3 0.0 2.2 2 0 0 2 2 2 1 Acyltransferase Fringe PF02434.16 CCF50445.1 - 2.8e-05 23.7 0.3 6.8e-05 22.4 0.3 1.5 1 1 0 1 1 1 1 Fringe-like PAN_4 PF14295.6 CCF50445.1 - 0.00072 19.4 1.3 0.0016 18.3 1.3 1.5 1 0 0 1 1 1 1 PAN domain PAN_1 PF00024.26 CCF50445.1 - 0.032 14.2 0.1 0.065 13.2 0.1 1.5 1 0 0 1 1 1 0 PAN domain DnaJ PF00226.31 CCF50447.1 - 5.8e-19 68.0 0.8 1e-18 67.2 0.8 1.4 1 0 0 1 1 1 1 DnaJ domain Gly-zipper_YMGG PF13441.6 CCF50447.1 - 0.016 14.9 5.1 0.03 14.1 5.1 1.4 1 0 0 1 1 1 0 YMGG-like Gly-zipper DUF456 PF04306.13 CCF50447.1 - 0.06 13.6 1.6 0.088 13.1 1.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF456) Bacteriocin_IIc PF10439.9 CCF50447.1 - 0.097 12.8 5.3 0.16 12.1 5.3 1.3 1 0 0 1 1 1 0 Bacteriocin class II with double-glycine leader peptide Gly-zipper_Omp PF13488.6 CCF50447.1 - 0.86 9.7 11.0 2.6 8.1 11.1 1.7 1 1 0 1 1 1 0 Glycine zipper Rick_17kDa_Anti PF05433.15 CCF50447.1 - 1.5 8.8 9.3 0.67 9.9 2.3 2.2 1 1 1 2 2 2 0 Glycine zipper 2TM domain APC_u5 PF16630.5 CCF50447.1 - 4.5 8.4 9.2 11 7.1 9.2 1.7 1 1 0 1 1 1 0 Unstructured region on APC between 1st and 2nd catenin-bdg motifs BPL_LplA_LipB PF03099.19 CCF50449.1 - 3.5e-05 23.7 0.0 5.5e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family DUF1284 PF06935.11 CCF50449.1 - 0.14 12.6 0.1 0.89 10.0 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1284) Opy2 PF09463.10 CCF50450.1 - 0.0017 18.6 19.3 0.0028 17.9 19.3 1.4 1 0 0 1 1 1 1 Opy2 protein DUF4381 PF14316.6 CCF50450.1 - 0.12 12.7 0.4 0.26 11.5 0.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) p450 PF00067.22 CCF50451.1 - 5.4e-74 249.6 0.0 1.7e-73 248.0 0.0 1.6 1 1 0 1 1 1 1 Cytochrome P450 Transp_cyt_pur PF02133.15 CCF50452.1 - 3.1e-129 431.6 40.4 3.6e-129 431.4 40.4 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin TEX19 PF15553.6 CCF50452.1 - 0.43 10.5 2.5 0.75 9.8 2.5 1.3 1 0 0 1 1 1 0 Testis-expressed protein 19 Ifi-6-16 PF06140.13 CCF50452.1 - 7.6 6.5 14.2 8.6 6.4 1.8 3.1 2 0 0 2 2 2 0 Interferon-induced 6-16 family DUF1338 PF07063.13 CCF50453.1 - 8.3e-110 367.0 0.0 1.1e-109 366.6 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1338) Aldedh PF00171.22 CCF50454.1 - 8.5e-121 403.7 0.0 9.9e-121 403.4 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.14 CCF50454.1 - 0.2 10.6 0.0 0.46 9.5 0.0 1.5 2 0 0 2 2 2 0 Acyl-CoA reductase (LuxC) Surp PF01805.20 CCF50455.1 - 3.3e-08 33.4 0.1 6.9e-08 32.4 0.1 1.5 1 0 0 1 1 1 1 Surp module RRM_1 PF00076.22 CCF50455.1 - 1.1e-05 25.1 0.0 2.9e-05 23.8 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CTD_bind PF04818.13 CCF50455.1 - 0.0013 19.5 0.0 0.0034 18.2 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase II-binding domain. RRM_7 PF16367.5 CCF50455.1 - 0.14 12.3 0.0 0.42 10.8 0.0 1.8 1 0 0 1 1 1 0 RNA recognition motif Rer1 PF03248.13 CCF50456.1 - 7.8e-77 256.8 0.0 9.4e-77 256.6 0.0 1.1 1 0 0 1 1 1 1 Rer1 family DUF2208 PF09973.9 CCF50456.1 - 0.068 12.8 0.2 0.068 12.8 0.2 1.8 2 0 0 2 2 2 0 Predicted membrane protein (DUF2208) IgaA PF07095.11 CCF50456.1 - 0.29 9.1 0.2 0.38 8.7 0.2 1.1 1 0 0 1 1 1 0 Intracellular growth attenuator protein IgaA Pyr_redox_2 PF07992.14 CCF50457.1 - 2.9e-38 131.8 0.0 4.6e-38 131.1 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CCF50457.1 - 1.3e-11 44.9 0.1 3.5e-07 30.7 0.0 3.5 3 1 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase EF-hand_1 PF00036.32 CCF50457.1 - 2.2e-11 42.5 3.0 5.8e-06 25.5 0.3 2.5 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 CCF50457.1 - 3.7e-10 40.1 0.2 0.00015 22.2 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 CCF50457.1 - 2.2e-09 36.5 2.4 0.00011 21.8 0.2 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 CCF50457.1 - 2.7e-08 32.9 2.0 0.0041 16.6 0.1 2.4 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 CCF50457.1 - 1.1e-05 25.2 1.4 0.0059 16.4 0.1 2.5 2 0 0 2 2 2 2 EF-hand domain pair Pyr_redox_3 PF13738.6 CCF50457.1 - 0.029 13.6 1.9 2 7.6 2.7 2.9 2 1 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_7 PF13241.6 CCF50457.1 - 0.08 13.4 0.2 0.79 10.2 0.0 2.5 3 0 0 3 3 3 0 Putative NAD(P)-binding MnhB PF04039.13 CCF50457.1 - 0.12 12.7 0.2 0.64 10.3 0.1 2.1 2 0 0 2 2 2 0 Domain related to MnhB subunit of Na+/H+ antiporter ATP19 PF11022.8 CCF50458.1 - 1.9e-24 85.8 0.3 2.8e-24 85.3 0.3 1.3 1 0 0 1 1 1 1 ATP synthase subunit K Yae1_N PF09811.9 CCF50459.1 - 5.1e-09 35.7 3.3 8.9e-09 34.9 3.3 1.4 1 0 0 1 1 1 1 Essential protein Yae1, N terminal Pentapeptide PF00805.22 CCF50459.1 - 0.14 11.9 0.9 0.3 10.8 0.9 1.5 1 0 0 1 1 1 0 Pentapeptide repeats (8 copies) Phage_lysis PF03245.13 CCF50459.1 - 0.42 10.7 4.9 1.1 9.4 1.4 3.2 2 1 0 2 2 2 0 Bacteriophage Rz lysis protein CCDC-167 PF15188.6 CCF50459.1 - 1.7 9.0 6.8 21 5.6 0.1 2.8 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 167 FlgN PF05130.12 CCF50459.1 - 3.3 8.2 9.0 21 5.6 0.7 3.2 2 1 1 3 3 3 0 FlgN protein DUF4718 PF15842.5 CCF50459.1 - 8.2 6.2 7.8 2.9 7.7 1.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4718) TFIIA_gamma_N PF02268.16 CCF50460.1 - 5.2e-24 84.0 0.1 7.4e-24 83.5 0.1 1.2 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit, helical domain TFIIA_gamma_C PF02751.14 CCF50460.1 - 2.9e-19 68.9 0.3 4.5e-19 68.3 0.3 1.3 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit DUF2841 PF11001.8 CCF50461.1 - 2.1e-36 124.7 0.2 3.6e-36 124.0 0.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2841) Stress-antifung PF01657.17 CCF50461.1 - 7.6 7.2 5.8 3.8 8.2 0.1 2.9 4 0 0 4 4 4 0 Salt stress response/antifungal CRAL_TRIO PF00650.20 CCF50462.1 - 4.9e-14 52.3 0.0 8.5e-14 51.6 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain SNF2_N PF00176.23 CCF50463.1 - 4.9e-57 193.2 0.0 9.6e-57 192.3 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 CCF50463.1 - 4.9e-14 52.6 0.0 1.5e-13 51.1 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 CCF50463.1 - 2.5e-10 40.6 0.0 5.8e-10 39.4 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 CCF50463.1 - 5e-08 32.9 0.0 1.2e-07 31.7 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase HDA2-3 PF11496.8 CCF50463.1 - 2.9e-05 23.4 0.1 5.9e-05 22.4 0.1 1.4 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 ERCC3_RAD25_C PF16203.5 CCF50463.1 - 0.0015 17.8 0.1 0.0033 16.7 0.1 1.5 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase TusA PF01206.17 CCF50463.1 - 0.015 15.1 0.0 2.3 8.1 0.0 2.6 2 0 0 2 2 2 0 Sulfurtransferase TusA DUF2764 PF10962.8 CCF50463.1 - 0.06 12.8 0.0 0.12 11.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2764) ASD1 PF08688.10 CCF50463.1 - 0.078 13.4 0.5 0.29 11.5 0.5 2.0 1 0 0 1 1 1 0 Apx/Shroom domain ASD1 AAA_22 PF13401.6 CCF50463.1 - 0.1 12.9 0.0 0.34 11.2 0.0 2.0 1 1 0 1 1 1 0 AAA domain PH PF00169.29 CCF50465.1 - 7e-07 29.7 0.0 1.7e-06 28.5 0.0 1.7 1 0 0 1 1 1 1 PH domain Roughex PF06020.11 CCF50465.1 - 0.5 9.4 6.1 0.88 8.6 6.1 1.3 1 0 0 1 1 1 0 Drosophila roughex protein CSRNP_N PF16019.5 CCF50465.1 - 1.5 8.7 10.0 0.03 14.3 2.2 2.0 2 0 0 2 2 2 0 Cysteine/serine-rich nuclear protein N-terminus Glycos_transf_4 PF00953.21 CCF50466.1 - 1.4e-34 119.4 4.8 1.4e-34 119.4 4.8 2.1 2 0 0 2 2 2 1 Glycosyl transferase family 4 DUF3413 PF11893.8 CCF50466.1 - 7.6 5.6 11.6 0.16 11.1 4.4 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3413) TFIIE_alpha PF02002.17 CCF50467.1 - 2.8e-09 36.8 0.7 5e-09 36.0 0.7 1.4 1 0 0 1 1 1 1 TFIIE alpha subunit Zn_Tnp_IS1595 PF12760.7 CCF50467.1 - 0.078 13.0 0.2 0.15 12.0 0.2 1.5 1 0 0 1 1 1 0 Transposase zinc-ribbon domain zf_UBZ PF18439.1 CCF50467.1 - 0.33 10.6 1.2 0.47 10.1 0.1 1.9 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger Trp_oprn_chp PF09534.10 CCF50467.1 - 0.62 9.8 6.6 1 9.1 0.9 2.3 1 1 1 2 2 2 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Cupin_8 PF13621.6 CCF50468.1 - 1.4e-45 156.0 0.2 3.9e-44 151.3 0.2 2.5 1 1 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.12 CCF50468.1 - 0.002 17.7 0.0 0.0093 15.5 0.0 2.1 2 0 0 2 2 2 1 Cupin superfamily protein Zn_clus PF00172.18 CCF50469.1 - 9.1e-07 28.9 11.8 9.1e-07 28.9 11.8 2.0 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Amidase_3 PF01520.18 CCF50469.1 - 0.052 13.7 0.2 0.1 12.7 0.2 1.4 1 0 0 1 1 1 0 N-acetylmuramoyl-L-alanine amidase Ion_trans PF00520.31 CCF50471.1 - 0.0075 15.5 18.1 0.016 14.4 18.1 1.6 1 1 0 1 1 1 1 Ion transport protein PKD_channel PF08016.12 CCF50471.1 - 0.031 13.0 13.0 0.075 11.7 10.7 2.3 2 1 0 2 2 2 0 Polycystin cation channel UQ_con PF00179.26 CCF50472.1 - 6.5e-47 158.7 0.0 7.4e-47 158.5 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 CCF50472.1 - 0.0029 17.3 0.0 0.0037 17.0 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.13 CCF50472.1 - 0.0099 15.7 0.0 0.018 14.9 0.0 1.5 1 1 0 1 1 1 1 UEV domain RWD PF05773.22 CCF50472.1 - 0.17 12.2 0.0 0.21 11.9 0.0 1.3 1 0 0 1 1 1 0 RWD domain WH1 PF00568.23 CCF50473.1 - 1.9e-25 89.0 0.0 2.7e-25 88.5 0.0 1.2 1 0 0 1 1 1 1 WH1 domain PBD PF00786.28 CCF50473.1 - 1.9e-09 37.7 0.1 3.7e-09 36.8 0.1 1.4 1 0 0 1 1 1 1 P21-Rho-binding domain WH2 PF02205.20 CCF50473.1 - 0.0083 15.9 0.1 0.027 14.3 0.1 2.0 1 0 0 1 1 1 1 WH2 motif DCP1 PF06058.13 CCF50473.1 - 0.016 15.1 0.0 0.023 14.6 0.0 1.2 1 0 0 1 1 1 0 Dcp1-like decapping family AA_permease PF00324.21 CCF50474.1 - 3.6e-118 395.2 41.8 4.5e-118 394.9 41.8 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 CCF50474.1 - 1.9e-35 122.5 44.8 2.4e-35 122.2 44.8 1.1 1 0 0 1 1 1 1 Amino acid permease CDC45 PF02724.14 CCF50474.1 - 0.11 10.8 6.2 0.048 12.0 1.2 2.1 2 0 0 2 2 2 0 CDC45-like protein DUF543 PF04418.12 CCF50475.1 - 2.4e-29 101.1 0.1 2.4e-29 101.1 0.1 1.7 2 1 0 2 2 2 1 Domain of unknown function (DUF543) DUF883 PF05957.13 CCF50475.1 - 0.00029 21.4 5.3 0.3 11.7 5.3 2.7 2 1 0 2 2 2 2 Bacterial protein of unknown function (DUF883) DUF4386 PF14329.6 CCF50475.1 - 0.11 12.4 0.1 0.14 12.0 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4386) RepB PF07506.11 CCF50475.1 - 0.11 12.5 2.3 0.15 12.2 2.3 1.2 1 0 0 1 1 1 0 RepB plasmid partitioning protein DUF4661 PF15576.6 CCF50475.1 - 0.15 11.9 0.9 0.22 11.4 0.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4661) DivIVA PF05103.13 CCF50475.1 - 0.25 11.4 6.6 0.35 10.9 6.6 1.3 1 0 0 1 1 1 0 DivIVA protein ATP-synt_B PF00430.18 CCF50475.1 - 1.4 9.0 11.2 2.1 8.5 11.2 1.3 1 0 0 1 1 1 0 ATP synthase B/B' CF(0) YtxH PF12732.7 CCF50475.1 - 4.5 7.9 11.3 0.14 12.7 4.3 2.1 2 0 0 2 2 2 0 YtxH-like protein DUF4536 PF15055.6 CCF50476.1 - 0.00046 20.4 0.7 0.00046 20.4 0.7 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF4536) Peroxidase_2 PF01328.17 CCF50478.1 - 1.1e-40 140.2 0.0 2e-40 139.3 0.0 1.4 1 0 0 1 1 1 1 Peroxidase, family 2 RNase_T PF00929.24 CCF50479.1 - 8.1e-09 36.2 0.0 1.7e-08 35.2 0.0 1.5 1 0 0 1 1 1 1 Exonuclease DNA_pol_A_exo1 PF01612.20 CCF50479.1 - 0.011 15.4 0.0 0.035 13.8 0.0 1.8 1 1 0 1 1 1 0 3'-5' exonuclease CHORD PF04968.12 CCF50479.1 - 0.038 14.7 1.5 0.11 13.3 1.5 1.7 1 0 0 1 1 1 0 CHORD PINIT PF14324.6 CCF50480.1 - 2.9e-28 99.1 0.5 5.3e-28 98.2 0.5 1.4 1 0 0 1 1 1 1 PINIT domain zf-MIZ PF02891.20 CCF50480.1 - 1.3e-20 72.9 4.9 2.2e-20 72.1 4.9 1.4 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger zf-Nse PF11789.8 CCF50480.1 - 3.2e-06 26.9 1.4 6.4e-06 25.9 1.4 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit Prok-RING_4 PF14447.6 CCF50480.1 - 0.23 11.3 2.3 0.57 10.1 2.3 1.7 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 CCF50480.1 - 2.1 8.2 6.0 14 5.6 6.4 2.0 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Whi5 PF08528.11 CCF50481.1 - 0.00092 18.8 0.1 0.0019 17.8 0.1 1.5 1 0 0 1 1 1 1 Whi5 like zf-H2C2_2 PF13465.6 CCF50482.1 - 2.2e-08 34.2 0.6 2.2e-08 34.2 0.6 3.3 4 0 0 4 4 4 1 Zinc-finger double domain zf-C2H2 PF00096.26 CCF50482.1 - 2.5e-07 30.8 11.6 2.3e-06 27.8 0.6 3.5 3 0 0 3 3 3 2 Zinc finger, C2H2 type FOXP-CC PF16159.5 CCF50482.1 - 1.3e-05 25.7 14.3 0.0063 17.1 1.7 4.4 2 2 3 5 5 5 2 FOXP coiled-coil domain zf-C2H2_4 PF13894.6 CCF50482.1 - 0.00015 22.3 11.3 0.0066 17.2 0.5 3.6 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_6 PF13912.6 CCF50482.1 - 0.0091 16.0 5.1 0.13 12.3 0.0 3.1 3 0 0 3 3 3 1 C2H2-type zinc finger zf-met PF12874.7 CCF50482.1 - 0.03 14.7 2.7 6 7.4 0.0 3.4 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf_ZIC PF18366.1 CCF50482.1 - 9.2 6.5 10.1 19 5.5 1.1 3.5 4 1 0 4 4 4 0 Zic proteins zinc finger domain DFP PF04127.15 CCF50483.1 - 1.1e-17 64.4 0.0 5.1e-10 39.5 0.0 2.2 2 0 0 2 2 2 2 DNA / pantothenate metabolism flavoprotein AA_permease PF00324.21 CCF50484.1 - 5.1e-115 384.8 39.4 6.2e-115 384.5 39.4 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 CCF50484.1 - 3.9e-33 114.9 43.9 6.8e-33 114.1 43.8 1.4 1 1 0 1 1 1 1 Amino acid permease DSPc PF00782.20 CCF50485.1 - 4.6e-19 68.5 0.6 8.3e-16 58.0 0.5 2.9 2 1 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 CCF50485.1 - 0.017 14.7 0.0 0.032 13.8 0.0 1.4 1 0 0 1 1 1 0 Protein-tyrosine phosphatase TT_ORF2 PF02957.15 CCF50486.1 - 0.051 14.5 2.8 0.069 14.1 2.8 1.3 1 0 0 1 1 1 0 TT viral ORF2 RNB PF00773.19 CCF50487.1 - 3.9e-95 318.9 0.0 6.1e-95 318.3 0.0 1.3 1 0 0 1 1 1 1 RNB domain Rrp44_S1 PF17215.3 CCF50487.1 - 7.8e-22 77.0 0.1 1.9e-21 75.8 0.1 1.7 1 0 0 1 1 1 1 S1 domain Rrp44_CSD1 PF17216.3 CCF50487.1 - 1.1e-19 70.6 0.0 2.5e-19 69.4 0.0 1.6 1 0 0 1 1 1 1 Rrp44-like cold shock domain OB_Dis3 PF17849.1 CCF50487.1 - 2.4e-18 65.9 0.0 5.7e-18 64.7 0.0 1.7 1 0 0 1 1 1 1 Dis3-like cold-shock domain 2 (CSD2) PIN_4 PF13638.6 CCF50487.1 - 2.8e-10 40.6 0.8 9.8e-10 38.8 0.8 2.0 1 1 0 1 1 1 1 PIN domain CSD2 PF17876.1 CCF50487.1 - 9.9e-08 32.1 0.0 7.9e-05 22.7 0.0 2.9 2 0 0 2 2 2 2 Cold shock domain OB_RNB PF08206.11 CCF50487.1 - 0.022 14.4 0.1 0.087 12.5 0.1 2.0 2 0 0 2 2 2 0 Ribonuclease B OB domain ISET-FN3_linker PF16625.5 CCF50491.1 - 0.13 12.9 3.5 1.4 9.5 0.8 3.4 2 0 0 2 2 2 0 Unstructured linking region I-set and fnIII on Brother of CDO GATA PF00320.27 CCF50492.1 - 7.6e-27 92.6 14.9 3.9e-14 52.0 3.9 2.4 2 0 0 2 2 2 2 GATA zinc finger DUF1752 PF08550.10 CCF50492.1 - 1.2e-09 37.8 0.9 3e-09 36.6 0.9 1.7 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) TF_Zn_Ribbon PF08271.12 CCF50492.1 - 0.00033 20.1 5.4 0.14 11.7 0.4 2.6 3 0 0 3 3 3 2 TFIIB zinc-binding Zn-ribbon_8 PF09723.10 CCF50492.1 - 0.00049 20.2 1.0 1.2 9.3 0.1 2.5 2 0 0 2 2 2 2 Zinc ribbon domain eIF-5_eIF-2B PF01873.17 CCF50492.1 - 0.098 12.5 4.1 6.9 6.6 0.3 2.7 2 0 0 2 2 2 0 Domain found in IF2B/IF5 zf-Sec23_Sec24 PF04810.15 CCF50492.1 - 0.2 11.7 4.6 1.5 8.9 0.4 2.5 2 0 0 2 2 2 0 Sec23/Sec24 zinc finger DZR PF12773.7 CCF50492.1 - 0.48 10.5 6.6 14 5.8 6.6 2.6 1 1 0 1 1 1 0 Double zinc ribbon zf-RRN7 PF11781.8 CCF50492.1 - 0.53 10.0 4.3 0.38 10.5 0.8 2.3 2 0 0 2 2 2 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 Auto_anti-p27 PF06677.12 CCF50492.1 - 1.8 8.8 6.0 9.7 6.5 0.7 2.4 2 0 0 2 2 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) TRAPPC-Trs85 PF12739.7 CCF50493.1 - 3e-112 375.6 0.0 4e-112 375.2 0.0 1.2 1 0 0 1 1 1 1 ER-Golgi trafficking TRAPP I complex 85 kDa subunit TRAPPC9-Trs120 PF08626.11 CCF50493.1 - 0.003 15.0 0.0 0.0046 14.4 0.0 1.2 1 0 0 1 1 1 1 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit SURF4 PF02077.15 CCF50494.1 - 1.2e-93 313.6 5.9 1.4e-93 313.4 5.9 1.0 1 0 0 1 1 1 1 SURF4 family HR_lesion PF05514.11 CCF50494.1 - 2.2 8.5 13.1 0.14 12.4 2.4 3.0 2 2 1 3 3 3 0 HR-like lesion-inducing EPL1 PF10513.9 CCF50495.1 - 0.45 10.9 9.9 2.4 8.5 6.3 2.7 2 0 0 2 2 2 0 Enhancer of polycomb-like Adaptin_binding PF10199.9 CCF50495.1 - 0.97 10.1 7.6 1.2 9.7 2.2 2.6 2 0 0 2 2 2 0 Alpha and gamma adaptin binding protein p34 Fungal_trans PF04082.18 CCF50496.1 - 1.8e-15 56.7 0.1 1.8e-15 56.7 0.1 2.4 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF50496.1 - 2.3e-07 30.8 8.9 4.6e-07 29.9 8.9 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain AGH PF17558.2 CCF50496.1 - 0.39 10.9 4.3 1 9.5 4.3 1.7 1 0 0 1 1 1 0 Androgenic gland hormone Pox_Ag35 PF03286.14 CCF50496.1 - 0.71 9.6 5.6 1.4 8.6 5.6 1.5 1 0 0 1 1 1 0 Pox virus Ag35 surface protein NOA36 PF06524.12 CCF50496.1 - 1.6 8.0 7.0 2.9 7.1 7.0 1.3 1 0 0 1 1 1 0 NOA36 protein PBP1_TM PF14812.6 CCF50496.1 - 3.2 8.2 6.6 8.8 6.8 6.6 1.7 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Glyco_hydro_47 PF01532.20 CCF50497.1 - 1.3e-151 505.7 0.0 1.7e-151 505.2 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Mito_carr PF00153.27 CCF50499.1 - 1.5e-50 169.1 3.5 1.1e-16 60.5 0.2 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Pkinase PF00069.25 CCF50500.1 - 2.9e-68 230.1 0.0 1.1e-67 228.2 0.0 1.9 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF50500.1 - 7.3e-49 166.4 0.1 2.1e-48 164.9 0.0 1.8 2 0 0 2 2 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CCF50500.1 - 7.2e-05 21.7 0.0 7.2e-05 21.7 0.0 2.8 3 0 0 3 3 3 1 Fungal protein kinase Pex14_N PF04695.13 CCF50500.1 - 0.018 15.7 37.8 0.17 12.5 25.6 2.7 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Haspin_kinase PF12330.8 CCF50500.1 - 0.062 12.2 2.2 1.8 7.4 0.0 2.5 3 0 0 3 3 2 0 Haspin like kinase domain Lin-8 PF03353.15 CCF50500.1 - 0.84 9.1 22.5 0.69 9.4 12.7 2.2 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist Band_3_cyto PF07565.13 CCF50500.1 - 4 7.2 13.4 2 8.2 4.4 2.5 2 0 0 2 2 2 0 Band 3 cytoplasmic domain FAM60A PF15396.6 CCF50500.1 - 4.4 7.2 13.9 7.6 6.5 7.0 2.3 2 0 0 2 2 2 0 Protein Family FAM60A DUF4551 PF15087.6 CCF50500.1 - 5 5.8 19.2 0.36 9.6 12.4 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF4551) Mlh1_C PF16413.5 CCF50500.1 - 6.2 6.1 11.6 3.5 6.9 0.2 2.2 2 0 0 2 2 2 0 DNA mismatch repair protein Mlh1 C-terminus MecA PF05389.12 CCF50500.1 - 8.2 6.0 10.3 24 4.4 0.3 2.4 2 0 0 2 2 2 0 Negative regulator of genetic competence (MecA) COG2 PF06148.11 CCF50501.1 - 2.4e-12 47.1 13.8 1.8e-11 44.3 0.1 4.5 6 0 0 6 6 6 2 COG (conserved oligomeric Golgi) complex component, COG2 DUF3510 PF12022.8 CCF50501.1 - 4.7e-08 33.5 2.0 7.8e-08 32.8 0.3 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF3510) adh_short PF00106.25 CCF50502.1 - 1.8e-33 115.6 0.0 5e-33 114.2 0.0 1.6 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF50502.1 - 1.1e-20 74.2 0.0 1.6e-20 73.7 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF50502.1 - 1.9e-14 54.0 0.2 3.4e-14 53.1 0.2 1.3 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 CCF50502.1 - 4e-06 26.9 0.0 6.6e-06 26.1 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding THF_DHG_CYH_C PF02882.19 CCF50502.1 - 0.00012 21.4 0.0 0.00021 20.7 0.0 1.4 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Polysacc_synt_2 PF02719.15 CCF50502.1 - 0.011 14.8 0.0 0.014 14.5 0.0 1.1 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein NAD_binding_7 PF13241.6 CCF50502.1 - 0.019 15.4 0.2 0.043 14.3 0.2 1.7 1 1 0 1 1 1 0 Putative NAD(P)-binding 3HCDH_N PF02737.18 CCF50502.1 - 0.026 14.4 0.1 0.039 13.8 0.1 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_2 PF03446.15 CCF50502.1 - 0.027 14.6 0.0 0.051 13.7 0.0 1.5 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase YjeF_N PF03853.15 CCF50502.1 - 0.03 14.2 0.0 0.054 13.4 0.0 1.4 1 0 0 1 1 1 0 YjeF-related protein N-terminus F420_oxidored PF03807.17 CCF50502.1 - 0.034 14.7 0.0 0.11 13.1 0.0 1.8 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Epimerase PF01370.21 CCF50502.1 - 0.043 13.3 0.0 0.098 12.1 0.0 1.6 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family Glyco_transf_4 PF13439.6 CCF50502.1 - 0.077 13.0 0.0 11 5.9 0.0 2.3 2 0 0 2 2 2 0 Glycosyltransferase Family 4 Sacchrp_dh_NADP PF03435.18 CCF50502.1 - 0.095 13.0 0.1 0.17 12.2 0.1 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain RmlD_sub_bind PF04321.17 CCF50502.1 - 0.11 11.6 0.0 0.16 11.1 0.0 1.2 1 0 0 1 1 1 0 RmlD substrate binding domain ApbA PF02558.16 CCF50502.1 - 0.12 12.0 0.0 0.2 11.3 0.0 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA GDP_Man_Dehyd PF16363.5 CCF50502.1 - 0.15 11.5 0.0 0.2 11.0 0.0 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase La PF05383.17 CCF50503.1 - 1.7e-22 79.2 0.2 2.2e-21 75.6 0.0 2.7 3 0 0 3 3 3 1 La domain RRM_1 PF00076.22 CCF50503.1 - 2.4e-07 30.5 0.2 6.5e-07 29.1 0.2 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 CCF50503.1 - 2.5e-05 24.2 0.1 0.00073 19.5 0.0 2.5 2 0 0 2 2 2 1 RNA binding motif Glu-tRNAGln PF02686.15 CCF50503.1 - 0.13 12.6 0.0 0.41 11.0 0.0 1.9 1 0 0 1 1 1 0 Glu-tRNAGln amidotransferase C subunit MFS_1 PF07690.16 CCF50504.1 - 0.022 13.7 0.5 0.03 13.3 0.5 1.1 1 0 0 1 1 1 0 Major Facilitator Superfamily Pro_isomerase PF00160.21 CCF50505.1 - 4e-51 173.4 0.1 4.7e-51 173.2 0.1 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Ank_2 PF12796.7 CCF50506.1 - 4.5e-18 65.6 0.4 3.5e-12 46.7 0.3 2.3 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CCF50506.1 - 2.4e-17 63.1 1.9 3.4e-12 46.6 0.8 3.0 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 CCF50506.1 - 1.2e-14 54.2 3.8 4.5e-08 33.2 0.1 4.2 2 2 2 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 CCF50506.1 - 2.1e-13 49.1 0.9 0.0046 17.4 0.0 4.5 4 0 0 4 4 4 3 Ankyrin repeat Ank PF00023.30 CCF50506.1 - 9.1e-13 48.0 4.0 0.00023 21.5 0.0 3.7 3 0 0 3 3 3 3 Ankyrin repeat IDO PF01231.18 CCF50507.1 - 1.7e-35 122.7 0.0 2.2e-35 122.3 0.0 1.1 1 0 0 1 1 1 1 Indoleamine 2,3-dioxygenase Chorismate_bind PF00425.18 CCF50508.1 - 1e-76 258.0 0.0 1.6e-76 257.3 0.0 1.3 1 0 0 1 1 1 1 chorismate binding enzyme GATase PF00117.28 CCF50508.1 - 2e-30 106.0 0.0 2.3e-20 73.2 0.0 2.3 2 0 0 2 2 2 2 Glutamine amidotransferase class-I Anth_synt_I_N PF04715.13 CCF50508.1 - 2.2e-13 50.6 0.0 5.5e-13 49.3 0.0 1.6 1 0 0 1 1 1 1 Anthranilate synthase component I, N terminal region Peptidase_C26 PF07722.13 CCF50508.1 - 1.1e-06 28.5 0.1 0.00016 21.5 0.0 2.5 2 0 0 2 2 2 2 Peptidase C26 COX5A PF02284.16 CCF50509.1 - 0.041 13.9 0.1 0.14 12.2 0.0 1.9 2 0 0 2 2 2 0 Cytochrome c oxidase subunit Va Foie-gras_1 PF11817.8 CCF50509.1 - 0.051 13.2 0.0 0.12 12.0 0.0 1.5 1 0 0 1 1 1 0 Foie gras liver health family 1 Zn_clus PF00172.18 CCF50510.1 - 1.9e-09 37.5 11.4 2.9e-09 36.9 11.4 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CN_hydrolase PF00795.22 CCF50516.1 - 8.7e-10 38.4 0.0 7.7e-08 32.0 0.0 2.8 3 0 0 3 3 3 2 Carbon-nitrogen hydrolase BolA PF01722.18 CCF50517.1 - 3.1e-18 65.8 0.1 4.8e-18 65.2 0.1 1.3 1 0 0 1 1 1 1 BolA-like protein UvrD-helicase PF00580.21 CCF50518.1 - 8.4e-15 55.1 0.0 1.8e-10 40.9 0.0 2.4 2 0 0 2 2 2 2 UvrD/REP helicase N-terminal domain UvrD_C PF13361.6 CCF50518.1 - 6.6e-13 48.8 0.0 1e-12 48.2 0.0 1.3 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_19 PF13245.6 CCF50518.1 - 6.9e-13 49.2 0.0 1.6e-12 48.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain UvrD_C_2 PF13538.6 CCF50518.1 - 1.5e-11 43.9 1.1 7.4e-11 41.7 1.1 2.3 1 1 0 1 1 1 1 UvrD-like helicase C-terminal domain Viral_helicase1 PF01443.18 CCF50518.1 - 2e-09 37.5 0.1 0.004 16.9 0.0 3.6 3 1 0 3 3 3 3 Viral (Superfamily 1) RNA helicase AAA_30 PF13604.6 CCF50518.1 - 9.3e-08 32.0 0.0 0.0041 16.9 0.0 2.9 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 CCF50518.1 - 0.0015 18.8 0.2 0.5 10.6 0.2 2.8 1 1 0 1 1 1 1 AAA domain PhoH PF02562.16 CCF50518.1 - 0.0047 16.4 0.0 0.12 11.8 0.0 2.3 2 0 0 2 2 2 1 PhoH-like protein Cyclin_N PF00134.23 CCF50520.1 - 3.8e-44 149.5 0.3 4.3e-43 146.1 0.1 2.3 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 CCF50520.1 - 8.9e-33 112.9 0.2 1.9e-32 111.8 0.2 1.6 1 0 0 1 1 1 1 Cyclin, C-terminal domain NOA36 PF06524.12 CCF50520.1 - 2.2 7.5 5.9 4 6.7 5.9 1.3 1 0 0 1 1 1 0 NOA36 protein JAB PF01398.21 CCF50521.1 - 6.2e-31 106.8 0.2 9e-31 106.3 0.2 1.2 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease CSN5_C PF18323.1 CCF50521.1 - 9.7e-27 93.7 0.2 2.3e-26 92.5 0.2 1.7 1 0 0 1 1 1 1 Cop9 signalosome subunit 5 C-terminal domain Prok-JAB PF14464.6 CCF50521.1 - 4.3e-05 23.3 0.0 7.4e-05 22.5 0.0 1.4 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain PTPlike_phytase PF14566.6 CCF50522.1 - 0.0002 21.5 0.2 0.0045 17.1 0.0 2.8 2 1 0 2 2 2 1 Inositol hexakisphosphate DSPc PF00782.20 CCF50522.1 - 0.00031 20.6 0.0 0.00067 19.5 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 CCF50522.1 - 0.021 14.8 0.0 0.05 13.6 0.0 1.5 1 0 0 1 1 1 0 Tyrosine phosphatase family Y_phosphatase PF00102.27 CCF50522.1 - 0.042 13.4 0.0 0.077 12.5 0.0 1.3 1 0 0 1 1 1 0 Protein-tyrosine phosphatase Aldedh PF00171.22 CCF50523.1 - 2.1e-122 409.0 0.0 2.5e-122 408.7 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family WD40 PF00400.32 CCF50524.1 - 2.3e-21 75.7 6.2 6.8e-05 23.6 0.0 5.4 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF50524.1 - 2.1e-07 31.1 0.0 1.4e-05 25.3 0.0 3.5 2 2 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Gcd10p PF04189.13 CCF50524.1 - 0.042 13.0 0.0 0.06 12.5 0.0 1.2 1 0 0 1 1 1 0 Gcd10p family Ge1_WD40 PF16529.5 CCF50524.1 - 0.12 11.3 0.0 1 8.2 0.0 2.4 2 1 1 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Pyr_redox_2 PF07992.14 CCF50525.1 - 2.3e-52 178.0 0.0 2.7e-52 177.8 0.0 1.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CCF50525.1 - 2.6e-19 69.6 0.1 1.8e-15 57.0 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CCF50525.1 - 3.2e-19 69.3 0.3 5.3e-16 58.9 0.0 2.8 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 CCF50525.1 - 5.6e-06 26.0 0.1 0.008 15.6 0.0 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase Thi4 PF01946.17 CCF50525.1 - 9.8e-06 25.0 0.1 0.00014 21.2 0.1 2.1 2 0 0 2 2 2 1 Thi4 family NAD_binding_8 PF13450.6 CCF50525.1 - 1.2e-05 25.4 0.1 0.0011 19.1 0.0 2.6 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 CCF50525.1 - 0.00025 20.3 1.8 0.0079 15.3 0.1 2.6 2 1 0 2 2 2 1 FAD binding domain FAD_binding_3 PF01494.19 CCF50525.1 - 0.00032 20.1 1.8 0.037 13.3 0.2 2.4 2 1 1 3 3 3 2 FAD binding domain GIDA PF01134.22 CCF50525.1 - 0.00092 18.4 5.3 0.0066 15.6 0.1 3.1 4 0 0 4 4 4 1 Glucose inhibited division protein A NAD_binding_7 PF13241.6 CCF50525.1 - 0.00096 19.6 0.4 0.073 13.5 0.0 3.0 3 0 0 3 3 3 1 Putative NAD(P)-binding K_oxygenase PF13434.6 CCF50525.1 - 0.00098 18.4 0.1 0.024 13.8 0.0 2.6 2 1 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) DAO PF01266.24 CCF50525.1 - 0.0013 18.4 0.2 0.007 16.0 0.1 2.3 1 1 0 1 1 1 1 FAD dependent oxidoreductase Trp_halogenase PF04820.14 CCF50525.1 - 0.0026 16.7 0.0 0.057 12.3 0.0 2.5 3 0 0 3 3 3 1 Tryptophan halogenase HI0933_like PF03486.14 CCF50525.1 - 0.0039 15.9 0.3 0.013 14.2 0.2 1.9 2 0 0 2 2 2 1 HI0933-like protein Shikimate_DH PF01488.20 CCF50525.1 - 0.066 13.3 0.1 11 6.1 0.0 2.4 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase DEAD PF00270.29 CCF50526.1 - 2.2e-33 115.5 0.2 4.9e-33 114.4 0.2 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CCF50526.1 - 8.5e-29 100.1 0.2 2.1e-28 98.9 0.2 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_30 PF13604.6 CCF50526.1 - 0.0071 16.1 0.0 0.02 14.6 0.0 1.7 2 0 0 2 2 2 1 AAA domain CDC27 PF09507.10 CCF50527.1 - 4.5e-102 342.6 31.5 6.6e-102 342.1 31.5 1.3 1 0 0 1 1 1 1 DNA polymerase subunit Cdc27 DUF5572 PF17733.1 CCF50528.1 - 2.1e-19 69.0 1.0 2.1e-19 69.0 1.0 2.2 2 0 0 2 2 2 1 Family of unknown function (DUF5572) Gcd10p PF04189.13 CCF50529.1 - 1.8e-76 257.1 1.2 1.4e-75 254.2 0.0 2.0 2 0 0 2 2 2 1 Gcd10p family PDDEXK_2 PF12784.7 CCF50529.1 - 0.068 12.7 0.1 0.068 12.7 0.1 1.6 2 0 0 2 2 2 0 PD-(D/E)XK nuclease family transposase Ssu72 PF04722.13 CCF50530.1 - 7.4e-82 273.5 0.0 8.6e-82 273.3 0.0 1.0 1 0 0 1 1 1 1 Ssu72-like protein LMWPc PF01451.21 CCF50530.1 - 0.16 12.4 0.6 0.59 10.5 0.2 2.1 2 0 0 2 2 2 0 Low molecular weight phosphotyrosine protein phosphatase Ras PF00071.22 CCF50531.1 - 9.3e-54 181.4 0.0 1.1e-53 181.2 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CCF50531.1 - 1.1e-21 77.2 0.0 8.7e-21 74.4 0.0 1.9 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CCF50531.1 - 8.8e-07 28.5 0.0 1.7e-06 27.6 0.0 1.5 1 1 0 1 1 1 1 ADP-ribosylation factor family PduV-EutP PF10662.9 CCF50531.1 - 0.13 12.0 0.5 2.6 7.8 0.5 2.5 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_7 PF12775.7 CCF50531.1 - 0.18 11.3 0.0 0.33 10.5 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region Gtr1_RagA PF04670.12 CCF50531.1 - 0.19 11.0 0.0 0.29 10.4 0.0 1.3 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region DEAD PF00270.29 CCF50533.1 - 1.9e-46 158.0 0.0 5.2e-46 156.6 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CCF50533.1 - 3.6e-28 98.1 0.0 6.9e-27 94.0 0.1 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CCF50533.1 - 2.2e-05 24.6 0.1 0.00011 22.2 0.0 2.2 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 CCF50533.1 - 0.06 13.7 0.0 7 7.0 0.0 2.7 2 0 0 2 2 2 0 AAA domain Nop10p PF04135.12 CCF50533.1 - 0.12 12.5 0.3 0.47 10.5 0.1 2.0 2 0 0 2 2 2 0 Nucleolar RNA-binding protein, Nop10p family DUF4355 PF14265.6 CCF50533.1 - 2.1 8.6 11.5 5.8 7.2 11.5 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4355) CMS1 PF14617.6 CCF50533.1 - 6.1 6.1 6.6 1.5 8.1 0.0 2.4 2 0 0 2 2 2 0 U3-containing 90S pre-ribosomal complex subunit Acyl-CoA_dh_1 PF00441.24 CCF50534.1 - 1.5e-34 119.3 0.7 2.1e-34 118.9 0.7 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 CCF50534.1 - 1.1e-17 64.0 0.0 1.9e-17 63.2 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 CCF50534.1 - 4.4e-12 46.6 0.2 3.6e-11 43.7 0.0 2.4 2 1 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 CCF50534.1 - 2.4e-10 40.8 0.1 3.4e-10 40.3 0.1 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Glyco_transf_8 PF01501.20 CCF50535.1 - 0.00024 20.8 0.1 0.14 11.7 0.0 2.3 2 1 0 2 2 2 2 Glycosyl transferase family 8 Nucleotid_trans PF03407.16 CCF50535.1 - 0.095 12.7 0.0 0.19 11.7 0.0 1.5 1 1 0 1 1 1 0 Nucleotide-diphospho-sugar transferase Mannosyl_trans3 PF11051.8 CCF50535.1 - 0.1 12.0 0.0 0.19 11.0 0.0 1.5 1 0 0 1 1 1 0 Mannosyltransferase putative SUZ PF12752.7 CCF50536.1 - 2.5e-15 56.9 4.3 2.5e-15 56.9 4.3 5.2 4 2 0 4 4 4 1 SUZ domain R3H PF01424.22 CCF50536.1 - 4.1e-09 36.3 0.6 7.3e-09 35.5 0.6 1.4 1 0 0 1 1 1 1 R3H domain UCH PF00443.29 CCF50537.1 - 2.6e-40 138.6 0.0 4e-40 137.9 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 CCF50537.1 - 1.4e-06 28.1 0.0 0.0086 15.7 0.0 2.4 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase DUF2267 PF10025.9 CCF50537.1 - 0.013 15.8 0.0 0.033 14.5 0.0 1.7 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2267) Toxin_8 PF07365.12 CCF50537.1 - 0.22 11.7 1.9 0.72 10.1 1.9 1.9 1 0 0 1 1 1 0 Alpha conotoxin precursor NAD_binding_1 PF00175.21 CCF50539.1 - 7.4e-26 90.9 0.0 1.4e-25 90.0 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 CCF50539.1 - 3.5e-19 69.0 0.0 6.9e-19 68.1 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 CCF50539.1 - 2.1e-06 28.0 0.0 2.3e-05 24.6 0.0 2.2 2 0 0 2 2 2 1 Ferric reductase NAD binding domain ABC_tran PF00005.27 CCF50540.1 - 2.6e-46 157.5 0.0 4e-23 82.4 0.0 3.2 2 1 0 2 2 2 2 ABC transporter ABC_tran_Xtn PF12848.7 CCF50540.1 - 1.3e-25 89.2 4.6 1.3e-25 89.2 4.6 3.5 4 0 0 4 4 3 1 ABC transporter AAA_21 PF13304.6 CCF50540.1 - 2e-17 64.0 0.0 0.0019 18.1 0.0 4.6 3 1 1 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CCF50540.1 - 4e-12 46.0 0.6 0.00011 21.7 0.0 4.3 4 0 0 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CCF50540.1 - 1.2e-07 31.4 0.2 0.0085 15.8 0.0 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 CCF50540.1 - 1.2e-06 28.5 0.7 0.027 14.6 0.1 3.0 2 1 0 2 2 2 2 50S ribosome-binding GTPase AAA_16 PF13191.6 CCF50540.1 - 3.8e-06 27.4 1.4 0.13 12.6 0.0 3.1 3 0 0 3 3 2 2 AAA ATPase domain AAA_22 PF13401.6 CCF50540.1 - 3.9e-06 27.2 0.4 0.11 12.8 0.0 3.9 4 1 0 4 4 4 2 AAA domain RsgA_GTPase PF03193.16 CCF50540.1 - 6.8e-06 26.1 0.1 0.059 13.3 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase NACHT PF05729.12 CCF50540.1 - 1.4e-05 25.1 0.2 0.02 14.8 0.0 2.7 2 0 0 2 2 2 2 NACHT domain AAA PF00004.29 CCF50540.1 - 0.00014 22.3 0.0 0.25 11.8 0.0 3.0 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 CCF50540.1 - 0.00019 22.0 0.0 0.88 10.1 0.0 3.6 3 0 0 3 3 3 1 AAA domain AAA_7 PF12775.7 CCF50540.1 - 0.0004 20.0 0.0 0.62 9.5 0.0 2.3 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA_25 PF13481.6 CCF50540.1 - 0.00052 19.6 0.0 2.4 7.7 0.0 3.4 4 0 0 4 4 4 2 AAA domain AAA_24 PF13479.6 CCF50540.1 - 0.00059 19.6 0.0 1 9.0 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_28 PF13521.6 CCF50540.1 - 0.00065 20.0 3.3 0.84 9.9 0.0 3.3 3 0 0 3 3 3 2 AAA domain RNA_helicase PF00910.22 CCF50540.1 - 0.00066 20.0 0.0 0.26 11.7 0.0 2.7 2 0 0 2 2 2 1 RNA helicase AAA_15 PF13175.6 CCF50540.1 - 0.0021 17.8 4.8 0.49 10.1 0.0 3.5 2 1 1 3 3 3 2 AAA ATPase domain AAA_14 PF13173.6 CCF50540.1 - 0.0035 17.4 0.0 2.2 8.3 0.0 2.7 2 0 0 2 2 2 1 AAA domain MeaB PF03308.16 CCF50540.1 - 0.0037 16.3 0.1 2.2 7.2 0.0 2.7 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_33 PF13671.6 CCF50540.1 - 0.007 16.5 7.5 0.4 10.8 0.0 3.8 4 1 0 4 4 3 2 AAA domain Roc PF08477.13 CCF50540.1 - 0.0081 16.4 0.0 3.3 7.9 0.0 2.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase NB-ARC PF00931.22 CCF50540.1 - 0.011 14.9 0.1 2.4 7.2 0.0 2.4 2 0 0 2 2 2 0 NB-ARC domain DUF87 PF01935.17 CCF50540.1 - 0.012 15.8 3.4 0.13 12.3 0.0 3.4 4 0 0 4 4 4 0 Helicase HerA, central domain cobW PF02492.19 CCF50540.1 - 0.017 14.7 0.2 6.2 6.4 0.0 3.0 3 0 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain AAA_23 PF13476.6 CCF50540.1 - 0.045 14.3 0.0 0.045 14.3 0.0 4.6 4 1 0 5 5 4 0 AAA domain AAA_27 PF13514.6 CCF50540.1 - 0.045 13.3 1.8 0.42 10.2 0.0 2.9 3 0 0 3 3 2 0 AAA domain NTPase_1 PF03266.15 CCF50540.1 - 0.071 13.0 0.0 9.6 6.1 0.0 2.7 2 0 0 2 2 2 0 NTPase SbcCD_C PF13558.6 CCF50540.1 - 0.079 13.2 0.2 15 5.9 0.1 3.6 2 2 0 2 2 2 0 Putative exonuclease SbcCD, C subunit IstB_IS21 PF01695.17 CCF50540.1 - 0.087 12.6 0.0 9.1 6.0 0.0 2.9 3 0 0 3 3 2 0 IstB-like ATP binding protein Pilt PF15453.6 CCF50540.1 - 0.14 11.6 0.5 0.25 10.7 0.5 1.3 1 0 0 1 1 1 0 Protein incorporated later into Tight Junctions ATP_bind_1 PF03029.17 CCF50540.1 - 0.14 11.9 0.0 3.1 7.5 0.0 2.5 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein Dynamin_N PF00350.23 CCF50540.1 - 0.17 12.0 3.1 0.98 9.5 0.0 3.1 4 0 0 4 4 3 0 Dynamin family AAA_5 PF07728.14 CCF50540.1 - 2.7 8.0 5.2 21 5.1 0.1 3.1 4 0 0 4 4 2 0 AAA domain (dynein-related subfamily) DUF4391 PF14335.6 CCF50540.1 - 4.9 6.8 8.9 6.7 6.3 0.1 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4391) Cyclase PF04199.13 CCF50541.1 - 5.3e-12 46.2 0.0 1.1e-11 45.1 0.0 1.6 1 0 0 1 1 1 1 Putative cyclase Mur_ligase_M PF08245.12 CCF50542.1 - 1.1e-07 32.1 0.0 1.8e-06 28.1 0.0 2.5 1 1 0 1 1 1 1 Mur ligase middle domain Mur_ligase_C PF02875.21 CCF50542.1 - 0.0081 16.4 0.0 0.23 11.8 0.0 2.7 2 0 0 2 2 2 1 Mur ligase family, glutamate ligase domain R3H PF01424.22 CCF50544.1 - 2e-09 37.3 1.3 2.6e-09 36.9 0.1 1.8 2 0 0 2 2 2 1 R3H domain RRM_1 PF00076.22 CCF50544.1 - 1.3e-08 34.5 0.1 3e-08 33.4 0.0 1.7 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) NCBP3 PF10309.9 CCF50545.1 - 1.3e-13 50.5 0.0 2.1e-13 49.9 0.0 1.4 1 0 0 1 1 1 1 Nuclear cap-binding protein subunit 3 ING PF12998.7 CCF50545.1 - 0.057 14.0 4.8 0.059 14.0 0.1 2.7 3 0 0 3 3 3 0 Inhibitor of growth proteins N-terminal histone-binding BTB PF00651.31 CCF50546.1 - 1.9e-10 40.9 0.6 0.0003 21.0 0.0 3.6 3 1 0 3 3 3 3 BTB/POZ domain MATH PF00917.26 CCF50546.1 - 0.25 11.5 1.1 1 9.5 0.3 2.1 1 1 1 2 2 2 0 MATH domain Striatin PF08232.12 CCF50547.1 - 6.9e-51 172.9 0.5 6.9e-51 172.9 0.5 3.6 2 1 0 2 2 2 1 Striatin family WD40 PF00400.32 CCF50547.1 - 2.5e-34 116.7 2.3 4.2e-07 30.6 0.0 7.3 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF50547.1 - 1.2e-06 28.7 0.0 2.6 8.4 0.0 5.6 4 2 3 7 7 7 2 Anaphase-promoting complex subunit 4 WD40 domain DUF4482 PF14818.6 CCF50547.1 - 0.15 12.9 0.1 0.15 12.9 0.1 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF4482) Sulfate_transp PF00916.20 CCF50548.1 - 1.1e-61 208.7 17.2 1.9e-61 208.0 17.2 1.2 1 0 0 1 1 1 1 Sulfate permease family cNMP_binding PF00027.29 CCF50548.1 - 8.7e-13 48.2 0.0 2.8e-12 46.6 0.0 1.9 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain STAS PF01740.21 CCF50548.1 - 3.7e-08 33.0 0.0 7.4e-08 32.0 0.0 1.4 1 0 0 1 1 1 1 STAS domain Med26 PF08711.11 CCF50549.1 - 3e-09 36.7 0.1 1.2e-08 34.9 0.0 2.0 2 0 0 2 2 2 1 TFIIS helical bundle-like domain DUF5560 PF17715.1 CCF50549.1 - 0.052 13.0 0.6 0.56 9.6 0.0 2.5 3 0 0 3 3 3 0 Family of unknown function (DUF5560) Neur_chan_memb PF02932.16 CCF50549.1 - 3.3 7.7 4.5 6.7 6.7 4.5 1.5 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region MTCP1 PF08991.10 CCF50550.1 - 4.9e-24 84.3 4.7 6.2e-24 84.0 4.7 1.1 1 0 0 1 1 1 1 Mature-T-Cell Proliferation I type CHCH PF06747.13 CCF50550.1 - 0.11 12.6 4.9 0.19 11.9 4.9 1.5 1 0 0 1 1 1 0 CHCH domain COesterase PF00135.28 CCF50552.1 - 0.00023 20.2 0.0 0.00045 19.2 0.0 1.4 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 CCF50552.1 - 0.0029 17.5 0.0 0.0059 16.5 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold DUF3565 PF12088.8 CCF50552.1 - 0.071 13.1 1.0 0.16 11.9 1.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3565) R3H PF01424.22 CCF50553.1 - 5.6e-15 55.1 0.1 1e-14 54.2 0.1 1.5 1 0 0 1 1 1 1 R3H domain zf-NF-X1 PF01422.17 CCF50553.1 - 2e-07 30.9 34.0 5.3e-06 26.4 14.4 14.2 15 1 0 15 15 15 5 NF-X1 type zinc finger FXMRP1_C_core PF12235.8 CCF50553.1 - 0.12 13.0 11.2 0.5 11.0 11.2 2.1 1 0 0 1 1 1 0 Fragile X-related 1 protein core C terminal HSP70 PF00012.20 CCF50554.1 - 1.9e-256 852.0 8.2 2.1e-256 851.8 8.2 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 CCF50554.1 - 7e-16 57.9 0.2 4.3e-14 52.1 0.1 2.4 2 0 0 2 2 2 1 MreB/Mbl protein Hydantoinase_A PF01968.18 CCF50554.1 - 0.0063 15.8 0.2 0.016 14.4 0.2 1.7 1 0 0 1 1 1 1 Hydantoinase/oxoprolinase PIN_8 PF18476.1 CCF50554.1 - 0.0077 16.1 5.3 0.06 13.2 1.7 2.2 2 0 0 2 2 2 1 PIN like domain FGGY_C PF02782.16 CCF50554.1 - 0.019 14.7 0.0 0.05 13.3 0.0 1.7 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, C-terminal domain FtsA PF14450.6 CCF50554.1 - 0.045 14.2 2.4 17 5.9 0.1 3.5 3 2 0 3 3 3 0 Cell division protein FtsA StbA PF06406.11 CCF50554.1 - 0.07 12.3 0.0 0.17 11.1 0.0 1.6 1 0 0 1 1 1 0 StbA protein 7TMR-HDED PF07697.11 CCF50554.1 - 0.079 13.1 10.6 0.14 12.2 10.6 1.6 1 1 0 1 1 1 0 7TM-HD extracellular DUF4226 PF10774.9 CCF50554.1 - 0.71 10.2 7.2 1.7 8.9 0.1 3.0 3 1 1 4 4 4 0 Domain of unknown function (DUF4226) Mcl1_mid PF12341.8 CCF50555.1 - 1.1e-83 281.0 0.0 1.5e-82 277.3 0.0 2.5 3 0 0 3 3 3 1 Minichromosome loss protein, Mcl1, middle region WD40 PF00400.32 CCF50555.1 - 5.1e-15 55.6 2.1 0.00028 21.6 0.0 6.6 7 0 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF50555.1 - 1.4e-07 31.7 0.0 0.00056 20.1 0.0 4.3 2 1 2 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain MMS1_N PF10433.9 CCF50555.1 - 0.2 10.2 0.0 3.2 6.3 0.0 2.1 2 0 0 2 2 2 0 Mono-functional DNA-alkylating methyl methanesulfonate N-term RAB3GAP2_N PF14655.6 CCF50555.1 - 0.23 10.7 0.0 8.8 5.5 0.0 2.3 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus UBA2_C PF16195.5 CCF50555.1 - 1.9 9.3 6.2 0.13 13.0 0.4 2.1 2 0 0 2 2 2 0 SUMO-activating enzyme subunit 2 C-terminus SAGA-Tad1 PF12767.7 CCF50556.1 - 6.1e-49 166.9 0.2 1.1e-48 166.1 0.2 1.4 1 0 0 1 1 1 1 Transcriptional regulator of RNA polII, SAGA, subunit BRCT_2 PF16589.5 CCF50558.1 - 0.044 14.2 0.0 0.091 13.2 0.0 1.5 1 0 0 1 1 1 0 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 CCF50558.1 - 0.045 14.1 0.0 0.091 13.2 0.0 1.6 1 0 0 1 1 1 0 BRCA1 C Terminus (BRCT) domain Pkinase PF00069.25 CCF50560.1 - 8.2e-43 146.7 0.1 6e-21 75.0 0.2 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CCF50560.1 - 1.2e-11 44.4 0.5 1.2e-08 34.6 0.1 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase RIO1 PF01163.22 CCF50560.1 - 0.26 10.9 0.1 0.47 10.0 0.1 1.3 1 0 0 1 1 1 0 RIO1 family tRNA-synt_1b PF00579.25 CCF50561.1 - 8e-22 77.9 0.0 4.9e-21 75.3 0.0 1.9 1 1 0 1 1 1 1 tRNA synthetases class I (W and Y) LSM PF01423.22 CCF50562.1 - 2.8e-13 49.3 0.1 3.5e-13 49.0 0.1 1.2 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 CCF50562.1 - 0.00083 19.4 0.0 0.00096 19.2 0.0 1.2 1 0 0 1 1 1 1 Ataxin 2 SM domain DUF150_C PF17384.2 CCF50562.1 - 0.088 12.9 0.1 0.12 12.5 0.1 1.4 1 1 0 1 1 1 0 RimP C-terminal SH3 domain TAF PF02969.17 CCF50563.1 - 9e-26 89.8 0.7 1.8e-25 88.9 0.7 1.5 1 0 0 1 1 1 1 TATA box binding protein associated factor (TAF) TAF6_C PF07571.13 CCF50563.1 - 1.2e-14 54.4 0.0 2.4e-14 53.4 0.0 1.5 1 0 0 1 1 1 1 TAF6 C-terminal HEAT repeat domain Histone PF00125.24 CCF50563.1 - 4.9e-05 23.7 1.0 0.00013 22.3 1.0 1.8 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TFIID-31kDa PF02291.15 CCF50563.1 - 0.0048 17.0 0.0 0.012 15.6 0.0 1.6 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit DUF4951 PF16309.5 CCF50563.1 - 0.044 13.8 0.0 0.097 12.7 0.0 1.6 1 0 0 1 1 1 0 Domian of unknown function (DUF4951) Tubulin PF00091.25 CCF50564.1 - 1.3e-70 237.6 0.0 1.9e-70 237.1 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 CCF50564.1 - 6.1e-43 146.0 0.0 1.1e-42 145.2 0.0 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 CCF50564.1 - 6.7e-07 29.6 0.0 1.3e-06 28.7 0.0 1.5 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_3 PF14881.6 CCF50564.1 - 0.0045 16.7 0.0 0.01 15.6 0.0 1.6 1 0 0 1 1 1 1 Tubulin domain DEAD_2 PF06733.15 CCF50564.1 - 0.17 11.5 0.0 0.3 10.7 0.0 1.3 1 0 0 1 1 1 0 DEAD_2 Fibrillarin PF01269.17 CCF50565.1 - 5.3e-105 349.6 0.0 6.5e-105 349.3 0.0 1.0 1 0 0 1 1 1 1 Fibrillarin GCD14 PF08704.10 CCF50565.1 - 6.7e-06 25.9 0.0 9.6e-06 25.4 0.0 1.1 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit Methyltr_RsmB-F PF01189.17 CCF50565.1 - 0.011 15.3 0.0 0.018 14.7 0.0 1.3 1 0 0 1 1 1 0 16S rRNA methyltransferase RsmB/F FtsJ PF01728.19 CCF50565.1 - 0.056 13.5 0.0 0.074 13.2 0.0 1.2 1 0 0 1 1 1 0 FtsJ-like methyltransferase PCMT PF01135.19 CCF50565.1 - 0.064 13.0 0.0 0.093 12.5 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Avl9 PF09794.9 CCF50566.1 - 1.1e-139 465.3 0.0 1.4e-139 465.0 0.0 1.1 1 0 0 1 1 1 1 Transport protein Avl9 DUF2347 PF09804.9 CCF50566.1 - 1e-10 41.7 0.0 0.00049 19.8 0.0 2.5 2 1 0 2 2 2 2 Uncharacterized conserved protein (DUF2347) SPA PF08616.10 CCF50566.1 - 3e-09 36.8 0.0 7.8e-05 22.6 0.0 2.4 2 0 0 2 2 2 2 Stabilization of polarity axis Afi1 PF07792.12 CCF50566.1 - 3.5e-05 24.3 0.0 8.9e-05 23.0 0.0 1.6 1 0 0 1 1 1 1 Docking domain of Afi1 for Arf3 in vesicle trafficking Thaumatin PF00314.17 CCF50568.1 - 0.00092 18.9 0.7 0.0036 17.0 0.6 2.0 1 1 1 2 2 2 1 Thaumatin family Phage-tail_2 PF09096.10 CCF50568.1 - 0.033 14.2 0.3 0.05 13.6 0.3 1.2 1 0 0 1 1 1 0 Baseplate structural protein, domain 2 CENP-H PF05837.12 CCF50569.1 - 6.5e-09 36.2 5.6 6.5e-09 36.2 5.6 2.7 1 1 1 2 2 2 1 Centromere protein H (CENP-H) Chorion_2 PF03964.15 CCF50569.1 - 0.084 13.7 0.4 0.22 12.4 0.4 1.6 1 0 0 1 1 1 0 Chorion family 2 NOA36 PF06524.12 CCF50569.1 - 0.94 8.7 9.3 1.8 7.9 9.3 1.5 1 0 0 1 1 1 0 NOA36 protein PIP5K PF01504.18 CCF50570.1 - 1e-97 326.7 0.0 1.8e-97 325.8 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase Ras PF00071.22 CCF50571.1 - 3.7e-31 107.9 0.0 1.3e-28 99.6 0.0 2.2 2 0 0 2 2 2 2 Ras family Roc PF08477.13 CCF50571.1 - 4.4e-27 94.7 0.0 6.9e-27 94.1 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CCF50571.1 - 2.1e-06 27.3 0.0 4e-06 26.4 0.0 1.4 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 CCF50571.1 - 0.00021 21.4 0.0 0.00035 20.6 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 CCF50571.1 - 0.005 16.4 0.0 0.22 11.1 0.0 3.0 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 CCF50571.1 - 0.014 14.7 0.0 0.024 14.0 0.0 1.3 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region DLIC PF05783.11 CCF50571.1 - 0.082 11.7 0.0 0.082 11.7 0.0 2.7 3 0 0 3 3 3 0 Dynein light intermediate chain (DLIC) TniB PF05621.11 CCF50571.1 - 0.11 11.9 0.0 0.3 10.5 0.0 1.6 2 0 0 2 2 2 0 Bacterial TniB protein Glucosamine_iso PF01182.20 CCF50572.1 - 2.8e-74 249.8 0.0 3.5e-74 249.5 0.0 1.0 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase Na_H_Exchanger PF00999.21 CCF50573.1 - 5.6e-65 219.6 35.5 8.5e-65 219.0 35.5 1.2 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family Spt5_N PF11942.8 CCF50573.1 - 0.22 12.6 9.6 1.5 9.9 2.2 3.1 3 0 0 3 3 3 0 Spt5 transcription elongation factor, acidic N-terminal SpoVAB PF13782.6 CCF50573.1 - 0.54 10.6 7.5 0.088 13.1 0.4 3.2 3 0 0 3 3 3 0 Stage V sporulation protein AB Nic96 PF04097.14 CCF50574.1 - 7.4e-184 612.7 0.4 9.1e-184 612.4 0.4 1.1 1 0 0 1 1 1 1 Nup93/Nic96 Cation_efflux PF01545.21 CCF50575.1 - 6.2e-20 71.8 5.7 8.2e-20 71.4 5.7 1.2 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 CCF50575.1 - 2.2e-09 37.3 0.0 5.8e-09 36.0 0.0 1.7 1 0 0 1 1 1 1 Dimerisation domain of Zinc Transporter tRNA-synt_2b PF00587.25 CCF50576.1 - 3.1e-39 134.8 0.0 4.8e-39 134.2 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 CCF50576.1 - 8.2e-11 41.9 0.0 2e-10 40.7 0.0 1.6 1 1 0 1 1 1 1 Anticodon binding domain RNA12 PF10443.9 CCF50577.1 - 2.6e-148 494.5 0.8 3.3e-148 494.1 0.8 1.1 1 0 0 1 1 1 1 RNA12 protein ATPase_2 PF01637.18 CCF50577.1 - 8e-05 22.7 0.0 0.00021 21.3 0.0 1.7 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea RRM_1 PF00076.22 CCF50577.1 - 0.00043 20.0 0.0 0.0039 17.0 0.0 2.6 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) AAA_14 PF13173.6 CCF50577.1 - 0.003 17.6 0.0 0.057 13.5 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 CCF50577.1 - 0.0051 17.2 0.0 0.03 14.7 0.1 2.4 2 1 0 2 2 2 1 AAA ATPase domain NB-ARC PF00931.22 CCF50577.1 - 0.071 12.3 0.0 0.16 11.2 0.0 1.6 1 0 0 1 1 1 0 NB-ARC domain DUF2487 PF10673.9 CCF50577.1 - 0.12 12.4 0.0 0.97 9.5 0.0 2.5 3 1 0 3 3 3 0 Protein of unknown function (DUF2487) TMCO5 PF14992.6 CCF50577.1 - 0.3 10.6 0.8 5 6.6 0.0 2.4 2 0 0 2 2 2 0 TMCO5 family JTB PF05439.12 CCF50579.1 - 0.007 16.4 0.0 0.007 16.4 0.0 1.6 2 0 0 2 2 2 1 Jumping translocation breakpoint protein (JTB) Mito_carr PF00153.27 CCF50580.1 - 0.0056 16.6 0.1 0.061 13.2 0.0 2.6 3 0 0 3 3 3 1 Mitochondrial carrier protein Clathrin PF00637.20 CCF50581.1 - 3.5e-16 59.4 0.0 0.00026 20.9 0.1 3.4 3 0 0 3 3 3 3 Region in Clathrin and VPS zf-C3H2C3 PF17122.5 CCF50581.1 - 2.3e-07 30.7 6.4 4.5e-07 29.8 6.4 1.5 1 0 0 1 1 1 1 Zinc-finger zf-C3HC4_2 PF13923.6 CCF50581.1 - 0.071 13.0 6.5 0.14 12.0 6.5 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CCF50581.1 - 0.12 12.4 5.3 0.22 11.5 5.3 1.5 1 0 0 1 1 1 0 zinc-RING finger domain zf-RING_UBOX PF13445.6 CCF50581.1 - 0.25 11.4 2.8 0.51 10.4 2.8 1.5 1 0 0 1 1 1 0 RING-type zinc-finger zf-RING_2 PF13639.6 CCF50581.1 - 4.2 7.8 6.2 9.3 6.7 6.2 1.6 1 0 0 1 1 1 0 Ring finger domain Ferlin_C PF16165.5 CCF50583.1 - 3.6 7.5 8.0 2.2 8.2 4.3 2.2 2 0 0 2 2 2 0 Ferlin C-terminus RAP1 PF07218.11 CCF50584.1 - 6.9 4.8 14.5 8.6 4.5 14.5 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) SOR_SNZ PF01680.17 CCF50585.1 - 9.2e-110 365.3 5.2 1.3e-109 364.8 5.2 1.2 1 0 0 1 1 1 1 SOR/SNZ family ThiG PF05690.14 CCF50585.1 - 1.5e-07 31.0 3.3 9.5e-06 25.1 0.1 2.4 2 0 0 2 2 2 2 Thiazole biosynthesis protein ThiG TetR_C_27 PF17935.1 CCF50585.1 - 0.0047 17.0 0.0 0.032 14.3 0.0 2.1 2 0 0 2 2 2 1 Tetracyclin repressor-like, C-terminal domain NanE PF04131.14 CCF50585.1 - 0.0049 16.1 0.2 0.1 11.8 0.0 2.4 2 0 0 2 2 2 1 Putative N-acetylmannosamine-6-phosphate epimerase IGPS PF00218.21 CCF50585.1 - 0.016 14.4 0.0 0.2 10.8 0.0 2.2 2 0 0 2 2 2 0 Indole-3-glycerol phosphate synthase Dus PF01207.17 CCF50585.1 - 0.058 12.5 0.2 0.71 8.9 0.0 2.2 2 0 0 2 2 2 0 Dihydrouridine synthase (Dus) RdRP_3 PF00998.23 CCF50585.1 - 0.22 10.2 0.0 0.3 9.7 0.0 1.1 1 0 0 1 1 1 0 Viral RNA dependent RNA polymerase UCR_TM PF02921.14 CCF50586.1 - 7.7e-11 42.3 3.2 1.1e-10 41.8 1.2 2.3 2 1 0 2 2 2 1 Ubiquinol cytochrome reductase transmembrane region Rieske PF00355.26 CCF50586.1 - 1.3e-10 41.0 0.0 2.5e-10 40.2 0.0 1.4 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Dynactin PF12455.8 CCF50587.1 - 8.6e-73 245.1 1.6 8.6e-73 245.1 1.6 4.0 5 0 0 5 5 5 1 Dynein associated protein CAP_GLY PF01302.25 CCF50587.1 - 2.9e-23 81.6 0.8 5e-23 80.9 0.8 1.4 1 0 0 1 1 1 1 CAP-Gly domain ATG16 PF08614.11 CCF50587.1 - 0.00069 19.9 10.3 0.00069 19.9 10.3 6.4 3 1 3 6 6 6 3 Autophagy protein 16 (ATG16) Taxilin PF09728.9 CCF50587.1 - 0.0011 18.2 5.8 0.0011 18.2 5.8 3.7 2 1 1 3 3 3 1 Myosin-like coiled-coil protein GAS PF13851.6 CCF50587.1 - 0.0022 17.4 16.8 0.0022 17.4 16.8 5.4 4 1 2 7 7 7 2 Growth-arrest specific micro-tubule binding BAAT_C PF08840.11 CCF50587.1 - 0.83 9.5 3.3 6 6.7 0.2 3.1 3 0 0 3 3 3 0 BAAT / Acyl-CoA thioester hydrolase C terminal Fcf1 PF04900.12 CCF50588.1 - 9.7e-29 99.7 0.3 2.1e-28 98.6 0.3 1.6 1 0 0 1 1 1 1 Fcf1 YoeB_toxin PF06769.14 CCF50588.1 - 0.043 13.8 0.0 0.089 12.8 0.0 1.4 1 0 0 1 1 1 0 YoeB-like toxin of bacterial type II toxin-antitoxin system TAFII55_N PF04658.13 CCF50589.1 - 0.057 13.1 0.0 0.12 12.1 0.0 1.5 1 0 0 1 1 1 0 TAFII55 protein conserved region DUF883 PF05957.13 CCF50589.1 - 1.8 9.2 3.9 0.62 10.7 0.2 2.2 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF883) Tocopherol_cycl PF14249.6 CCF50590.1 - 0.00019 20.7 0.2 0.00049 19.3 0.1 1.7 2 0 0 2 2 2 1 Tocopherol cyclase DUF4667 PF15700.5 CCF50590.1 - 0.74 9.9 11.0 1.1 9.3 11.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4667) Ndc1_Nup PF09531.10 CCF50590.1 - 2.9 6.5 6.5 3.9 6.0 6.5 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Glyco_hydro_5_C PF18564.1 CCF50591.1 - 8.4e-18 64.7 0.2 1.7e-17 63.7 0.2 1.5 1 0 0 1 1 1 1 Glycoside hydrolase family 5 C-terminal domain Cellulase PF00150.18 CCF50591.1 - 1.6e-10 40.9 0.0 0.00017 21.1 0.0 2.9 2 1 0 2 2 2 2 Cellulase (glycosyl hydrolase family 5) DUF974 PF06159.13 CCF50592.1 - 1e-70 238.3 0.0 1.5e-70 237.8 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF974) IDO PF01231.18 CCF50593.1 - 8.1e-150 499.4 0.0 1.1e-149 499.0 0.0 1.1 1 0 0 1 1 1 1 Indoleamine 2,3-dioxygenase ACPS PF01648.20 CCF50593.1 - 3.5e-11 43.2 0.0 1e-10 41.8 0.0 1.8 1 0 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily Ras PF00071.22 CCF50594.1 - 1.2e-65 220.1 1.1 1.5e-65 219.7 1.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CCF50594.1 - 2.7e-36 124.4 0.1 5.1e-36 123.5 0.1 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CCF50594.1 - 6.5e-18 64.8 0.2 8.8e-18 64.4 0.2 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 CCF50594.1 - 4e-07 30.1 1.3 0.0056 16.6 0.4 2.3 1 1 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 CCF50594.1 - 5.6e-06 26.0 0.3 1.6e-05 24.6 0.3 1.8 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 CCF50594.1 - 2.9e-05 23.6 0.1 3.4e-05 23.3 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 CCF50594.1 - 5.3e-05 22.7 0.1 6.9e-05 22.4 0.1 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 CCF50594.1 - 5.6e-05 23.2 0.8 6.7e-05 22.9 0.1 1.6 2 0 0 2 2 1 1 50S ribosome-binding GTPase AAA PF00004.29 CCF50594.1 - 0.0057 17.1 0.1 0.82 10.1 0.0 2.3 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) FeoB_N PF02421.18 CCF50594.1 - 0.0072 15.9 0.1 0.066 12.7 0.1 2.1 1 1 0 1 1 1 1 Ferrous iron transport protein B AAA_16 PF13191.6 CCF50594.1 - 0.013 15.9 0.0 0.019 15.4 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain AAA_5 PF07728.14 CCF50594.1 - 0.02 14.9 0.0 0.038 14.0 0.0 1.6 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_29 PF13555.6 CCF50594.1 - 0.023 14.4 0.3 0.14 11.9 0.0 2.3 2 0 0 2 2 2 0 P-loop containing region of AAA domain DUF3873 PF12989.7 CCF50594.1 - 0.027 14.8 0.1 0.052 13.9 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function, B. Theta Gene description (DUF3873) AAA_22 PF13401.6 CCF50594.1 - 0.039 14.2 0.0 0.072 13.4 0.0 1.8 1 1 0 1 1 1 0 AAA domain TniB PF05621.11 CCF50594.1 - 0.05 13.0 0.0 0.29 10.5 0.0 2.0 2 0 0 2 2 2 0 Bacterial TniB protein AAA_7 PF12775.7 CCF50594.1 - 0.058 12.9 0.0 0.18 11.3 0.0 1.7 2 0 0 2 2 2 0 P-loop containing dynein motor region ABC_tran PF00005.27 CCF50594.1 - 0.058 13.9 0.1 0.11 13.1 0.1 1.7 1 1 0 1 1 1 0 ABC transporter Septin PF00735.18 CCF50594.1 - 0.07 12.4 0.1 0.18 11.1 0.0 1.6 2 0 0 2 2 2 0 Septin PduV-EutP PF10662.9 CCF50594.1 - 0.083 12.6 0.1 1.5 8.6 0.0 2.4 1 1 1 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Nse4_C PF08743.10 CCF50595.1 - 7.7e-26 90.2 0.1 2.7e-25 88.4 0.0 2.0 2 0 0 2 2 2 1 Nse4 C-terminal Nse4-Nse3_bdg PF15412.6 CCF50595.1 - 9.8e-15 54.4 0.2 9.8e-15 54.4 0.2 2.2 2 0 0 2 2 2 1 Binding domain of Nse4/EID3 to Nse3-MAGE SRR1 PF07985.12 CCF50596.1 - 3e-16 59.2 0.0 3.1e-09 36.7 0.0 2.5 2 0 0 2 2 2 2 SRR1 UNC-79 PF14776.6 CCF50596.1 - 0.29 9.8 0.6 2.5 6.7 0.9 1.9 2 0 0 2 2 2 0 Cation-channel complex subunit UNC-79 Caskin1-CID PF16600.5 CCF50596.1 - 2.2 8.9 7.1 8.8 7.0 7.1 2.0 1 0 0 1 1 1 0 Caskin1 CASK-interaction domain Erf4 PF10256.9 CCF50597.1 - 1.2e-31 109.2 0.0 1.5e-31 108.9 0.0 1.1 1 0 0 1 1 1 1 Golgin subfamily A member 7/ERF4 family RNA_pol_Rpb5_C PF01191.19 CCF50598.1 - 1.9e-32 110.9 0.1 3.8e-32 110.0 0.1 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb5, C-terminal domain RNA_pol_Rpb5_N PF03871.14 CCF50598.1 - 1.6e-28 99.1 0.6 2.5e-28 98.5 0.6 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb5, N-terminal domain Mrr_cat PF04471.12 CCF50598.1 - 8.1e-05 22.6 0.1 0.00019 21.4 0.0 1.7 2 1 0 2 2 2 1 Restriction endonuclease KH_1 PF00013.29 CCF50599.1 - 6.2e-35 118.8 0.2 5.4e-08 32.6 0.0 6.5 6 0 0 6 6 6 5 KH domain ArsA_ATPase PF02374.15 CCF50600.1 - 4.6e-113 377.4 0.4 5.3e-113 377.2 0.4 1.0 1 0 0 1 1 1 1 Anion-transporting ATPase AAA_31 PF13614.6 CCF50600.1 - 7.7e-13 48.7 0.0 2.3e-12 47.2 0.0 1.7 2 0 0 2 2 2 1 AAA domain CbiA PF01656.23 CCF50600.1 - 7.7e-12 45.4 0.0 1.6e-11 44.4 0.0 1.6 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain CBP_BcsQ PF06564.12 CCF50600.1 - 2.2e-05 24.1 0.0 6.2e-05 22.6 0.0 1.7 2 0 0 2 2 2 1 Cellulose biosynthesis protein BcsQ ParA PF10609.9 CCF50600.1 - 4.1e-05 23.2 5.2 0.00043 19.8 1.5 2.8 2 1 1 3 3 3 1 NUBPL iron-transfer P-loop NTPase SRP54 PF00448.22 CCF50600.1 - 5.1e-05 23.0 0.4 0.00061 19.5 0.1 2.5 2 1 1 3 3 3 1 SRP54-type protein, GTPase domain Fer4_NifH PF00142.18 CCF50600.1 - 5.4e-05 22.8 0.1 0.00014 21.4 0.0 1.7 2 0 0 2 2 2 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family PhoH PF02562.16 CCF50600.1 - 0.013 14.9 0.0 0.029 13.8 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein AAA_25 PF13481.6 CCF50600.1 - 0.051 13.1 2.0 1.1 8.8 1.1 2.9 2 1 0 2 2 2 0 AAA domain AAA_24 PF13479.6 CCF50600.1 - 0.054 13.2 0.0 0.16 11.7 0.0 1.7 1 1 0 1 1 1 0 AAA domain NB-ARC PF00931.22 CCF50600.1 - 0.099 11.8 0.0 0.17 11.1 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain BPL_N PF09825.9 CCF50601.1 - 1.3e-118 396.4 0.0 1.8e-118 396.0 0.0 1.2 1 0 0 1 1 1 1 Biotin-protein ligase, N terminal BPL_LplA_LipB PF03099.19 CCF50601.1 - 4.1e-18 65.5 0.0 8e-18 64.6 0.0 1.5 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family BPL_C PF02237.17 CCF50601.1 - 0.029 14.3 0.1 0.078 12.9 0.1 1.8 1 0 0 1 1 1 0 Biotin protein ligase C terminal domain RTC PF01137.21 CCF50602.1 - 5.3e-49 166.4 0.0 6.3e-49 166.2 0.0 1.0 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase RTC_insert PF05189.13 CCF50602.1 - 6.4e-34 116.6 0.0 1.1e-33 115.8 0.0 1.4 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase (RTC), insert domain Ribonuc_2-5A PF06479.12 CCF50603.1 - 2e-43 147.6 0.0 3.9e-43 146.7 0.0 1.5 1 0 0 1 1 1 1 Ribonuclease 2-5A Pkinase PF00069.25 CCF50603.1 - 2.9e-38 131.8 0.0 2e-37 129.0 0.0 2.2 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF50603.1 - 3.3e-19 69.2 0.0 1.4e-18 67.1 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase PQQ_2 PF13360.6 CCF50603.1 - 1.1e-05 25.1 1.1 0.0011 18.6 0.0 3.0 2 1 0 3 3 3 1 PQQ-like domain Pkinase_fungal PF17667.1 CCF50603.1 - 0.0001 21.2 2.3 0.00015 20.7 0.0 2.3 3 0 0 3 3 3 1 Fungal protein kinase PQQ PF01011.21 CCF50603.1 - 0.00085 19.1 0.0 0.014 15.3 0.0 2.8 3 0 0 3 3 3 1 PQQ enzyme repeat Kdo PF06293.14 CCF50603.1 - 0.0014 18.1 0.0 0.0029 17.0 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CCF50603.1 - 0.069 13.1 0.1 0.15 11.9 0.1 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.9 CCF50603.1 - 0.088 12.3 0.0 0.15 11.6 0.0 1.3 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL TPR_14 PF13428.6 CCF50604.1 - 6.5e-08 32.8 25.6 22 6.2 0.1 12.3 9 4 5 14 14 14 0 Tetratricopeptide repeat TPR_19 PF14559.6 CCF50604.1 - 1.8e-07 31.6 3.6 0.086 13.4 0.5 6.8 8 0 0 8 8 8 1 Tetratricopeptide repeat NRDE-2 PF08424.10 CCF50604.1 - 4e-07 29.5 0.0 0.0022 17.2 0.0 4.8 2 2 0 3 3 3 1 NRDE-2, necessary for RNA interference TPR_8 PF13181.6 CCF50604.1 - 0.00037 20.5 8.1 5.6 7.4 0.0 6.3 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_12 PF13424.6 CCF50604.1 - 0.0012 19.1 10.7 10 6.5 0.0 7.4 8 1 0 8 8 8 2 Tetratricopeptide repeat TPR_2 PF07719.17 CCF50604.1 - 0.0013 18.7 16.1 14 6.1 0.3 8.8 9 0 0 9 9 9 1 Tetratricopeptide repeat MIT PF04212.18 CCF50604.1 - 0.02 14.9 2.6 1 9.5 0.1 4.2 3 1 0 3 3 3 0 MIT (microtubule interacting and transport) domain Mad3_BUB1_I PF08311.12 CCF50604.1 - 0.046 13.7 11.9 0.13 12.2 0.3 6.3 8 1 1 9 9 9 0 Mad3/BUB1 homology region 1 Suf PF05843.14 CCF50604.1 - 0.11 12.5 27.5 0.53 10.2 0.1 6.7 5 2 0 6 6 6 0 Suppressor of forked protein (Suf) Zn_clus PF00172.18 CCF50605.1 - 4.5e-06 26.7 6.5 4.5e-06 26.7 6.5 2.2 3 0 0 3 3 3 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Brix PF04427.18 CCF50606.1 - 1e-48 166.0 0.0 1.6e-48 165.4 0.0 1.2 1 0 0 1 1 1 1 Brix domain Nop14 PF04147.12 CCF50606.1 - 0.023 12.9 48.6 0.039 12.2 48.6 1.4 1 0 0 1 1 1 0 Nop14-like family CDC27 PF09507.10 CCF50606.1 - 9.8 5.4 39.3 10 5.3 29.8 2.4 2 0 0 2 2 2 0 DNA polymerase subunit Cdc27 CybS PF05328.12 CCF50607.1 - 2.4e-40 137.3 0.0 2.9e-40 137.0 0.0 1.1 1 0 0 1 1 1 1 CybS, succinate dehydrogenase cytochrome B small subunit Ribosomal_L3 PF00297.22 CCF50608.1 - 2.6e-187 622.3 11.1 2.9e-187 622.1 11.1 1.0 1 0 0 1 1 1 1 Ribosomal protein L3 Oxidored_molyb PF00174.19 CCF50609.1 - 1.5e-56 190.7 0.0 2.5e-56 190.0 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase molybdopterin binding domain Mo-co_dimer PF03404.16 CCF50609.1 - 2.7e-45 153.8 0.1 4.9e-45 152.9 0.1 1.5 1 0 0 1 1 1 1 Mo-co oxidoreductase dimerisation domain NAD_binding_1 PF00175.21 CCF50609.1 - 2.2e-28 99.1 0.0 4.6e-28 98.0 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 CCF50609.1 - 1.6e-24 86.1 0.0 6.4e-24 84.2 0.0 2.1 3 0 0 3 3 3 1 Oxidoreductase FAD-binding domain Cyt-b5 PF00173.28 CCF50609.1 - 1.2e-20 73.4 0.1 2.7e-20 72.3 0.1 1.7 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain NAD_binding_6 PF08030.12 CCF50609.1 - 0.0098 16.0 0.0 0.083 13.0 0.0 2.2 2 0 0 2 2 2 1 Ferric reductase NAD binding domain Pyr_redox_2 PF07992.14 CCF50610.1 - 5.1e-40 137.5 0.0 8.3e-40 136.8 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NIR_SIR PF01077.22 CCF50610.1 - 2.1e-19 69.6 0.0 3.5e-19 68.9 0.0 1.3 1 0 0 1 1 1 1 Nitrite and sulphite reductase 4Fe-4S domain Pyr_redox PF00070.27 CCF50610.1 - 5.1e-14 52.6 2.5 1.6e-13 51.0 0.3 2.8 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Fer2_BFD PF04324.15 CCF50610.1 - 4.8e-13 49.2 7.7 3.8e-10 39.9 3.4 3.1 3 0 0 3 3 3 2 BFD-like [2Fe-2S] binding domain Rieske_2 PF13806.6 CCF50610.1 - 1.1e-12 47.7 0.0 3.1e-12 46.4 0.0 1.8 1 0 0 1 1 1 1 Rieske-like [2Fe-2S] domain NIR_SIR_ferr PF03460.17 CCF50610.1 - 6e-10 38.8 0.0 1.4e-09 37.6 0.0 1.7 1 0 0 1 1 1 1 Nitrite/Sulfite reductase ferredoxin-like half domain Rieske PF00355.26 CCF50610.1 - 7.9e-10 38.5 0.1 2.2e-09 37.1 0.0 1.8 2 0 0 2 2 2 1 Rieske [2Fe-2S] domain NAD_binding_9 PF13454.6 CCF50610.1 - 1.5e-05 25.1 0.5 0.74 9.8 0.0 3.6 2 1 0 3 3 3 2 FAD-NAD(P)-binding FAD_binding_2 PF00890.24 CCF50610.1 - 8.2e-05 21.9 0.6 0.00086 18.5 0.0 2.5 1 1 1 2 2 2 1 FAD binding domain DAO PF01266.24 CCF50610.1 - 0.00038 20.1 0.4 8.4 5.9 0.1 4.0 3 1 1 4 4 4 2 FAD dependent oxidoreductase Rubredoxin_C PF18267.1 CCF50610.1 - 0.00039 20.3 0.7 1.3 9.0 0.0 2.7 2 0 0 2 2 2 2 Rubredoxin NAD+ reductase C-terminal domain TrkA_N PF02254.18 CCF50610.1 - 0.066 13.5 1.3 4.4 7.6 0.2 2.6 2 0 0 2 2 2 0 TrkA-N domain MFS_1 PF07690.16 CCF50611.1 - 5.6e-32 111.0 27.0 5.6e-32 111.0 27.0 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily GATase_2 PF00310.21 CCF50612.1 - 9.8e-175 581.3 0.0 1.3e-174 580.9 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferases class-II Glu_synthase PF01645.17 CCF50612.1 - 1e-155 518.4 0.1 2.1e-155 517.4 0.0 1.6 2 0 0 2 2 2 1 Conserved region in glutamate synthase Glu_syn_central PF04898.14 CCF50612.1 - 1.5e-116 388.7 0.0 1.5e-113 379.0 0.0 2.2 2 0 0 2 2 2 2 Glutamate synthase central domain GXGXG PF01493.19 CCF50612.1 - 8e-85 283.2 0.3 1.3e-84 282.6 0.3 1.3 1 0 0 1 1 1 1 GXGXG motif Pyr_redox_2 PF07992.14 CCF50612.1 - 2.4e-21 76.3 0.1 3.3e-20 72.5 0.1 2.3 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Fer4_20 PF14691.6 CCF50612.1 - 3.3e-21 75.2 0.1 6.2e-21 74.3 0.1 1.5 1 0 0 1 1 1 1 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster NAD_binding_8 PF13450.6 CCF50612.1 - 5e-09 36.3 0.2 2.5e-08 34.0 0.1 2.3 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 CCF50612.1 - 5.3e-08 33.3 0.5 0.0003 21.3 0.1 3.5 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 CCF50612.1 - 4.3e-06 26.3 0.0 7.2e-06 25.5 0.0 1.3 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase Pyr_redox_3 PF13738.6 CCF50612.1 - 9.8e-06 25.0 0.6 0.082 12.1 0.0 2.9 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 CCF50612.1 - 1.9e-05 23.9 0.8 0.079 12.0 0.1 2.3 2 0 0 2 2 2 2 Glucose inhibited division protein A HI0933_like PF03486.14 CCF50612.1 - 2.1e-05 23.5 1.6 0.00015 20.6 0.2 2.4 2 0 0 2 2 2 1 HI0933-like protein DAO PF01266.24 CCF50612.1 - 4.6e-05 23.2 0.7 0.00068 19.3 0.4 2.5 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 CCF50612.1 - 6.8e-05 22.1 2.2 0.0035 16.5 0.1 2.7 2 0 0 2 2 2 1 FAD binding domain FAD_oxidored PF12831.7 CCF50612.1 - 6.8e-05 22.4 5.8 0.0018 17.7 0.3 2.3 2 0 0 2 2 2 2 FAD dependent oxidoreductase FMN_dh PF01070.18 CCF50612.1 - 0.0022 17.1 0.8 0.023 13.7 0.8 2.2 2 0 0 2 2 2 1 FMN-dependent dehydrogenase Lycopene_cycl PF05834.12 CCF50612.1 - 0.0024 17.0 0.2 0.35 9.8 0.1 3.2 3 0 0 3 3 3 1 Lycopene cyclase protein NAD_binding_7 PF13241.6 CCF50612.1 - 0.0033 17.8 0.1 1.6 9.2 0.0 2.7 2 0 0 2 2 2 1 Putative NAD(P)-binding FAD_binding_3 PF01494.19 CCF50612.1 - 0.0037 16.6 0.3 0.012 14.9 0.0 1.8 2 0 0 2 2 2 1 FAD binding domain AdoHcyase_NAD PF00670.21 CCF50612.1 - 0.028 14.5 0.6 18 5.4 0.1 3.4 3 0 0 3 3 3 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain FMO-like PF00743.19 CCF50612.1 - 0.029 12.8 0.1 0.66 8.3 0.0 2.6 3 0 0 3 3 3 0 Flavin-binding monooxygenase-like AlaDh_PNT_C PF01262.21 CCF50612.1 - 0.031 13.6 0.4 8.5 5.6 0.1 2.4 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain IlvN PF07991.12 CCF50612.1 - 0.076 12.6 1.2 0.46 10.1 0.1 2.6 3 0 0 3 3 3 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain Thi4 PF01946.17 CCF50612.1 - 0.1 11.8 1.9 0.19 10.9 0.2 2.0 2 0 0 2 2 2 0 Thi4 family GATase_6 PF13522.6 CCF50612.1 - 0.12 12.6 0.0 0.29 11.3 0.0 1.6 1 0 0 1 1 1 0 Glutamine amidotransferase domain 2-Hacid_dh_C PF02826.19 CCF50612.1 - 0.13 11.6 0.0 0.56 9.5 0.0 1.9 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Adenylsucc_synt PF00709.21 CCF50613.1 - 3.9e-176 586.1 0.0 4.4e-176 585.9 0.0 1.0 1 0 0 1 1 1 1 Adenylosuccinate synthetase DNA_primase_lrg PF04104.14 CCF50614.1 - 2.6e-87 292.6 0.0 4.2e-87 291.9 0.0 1.3 1 0 0 1 1 1 1 Eukaryotic and archaeal DNA primase, large subunit Nucleoporin_N PF08801.11 CCF50615.1 - 4.9e-42 144.2 0.0 6.8e-42 143.7 0.0 1.2 1 0 0 1 1 1 1 Nup133 N terminal like Nucleoporin_C PF03177.14 CCF50615.1 - 5.5e-32 111.3 5.7 8.4e-32 110.7 5.7 1.2 1 0 0 1 1 1 1 Non-repetitive/WGA-negative nucleoporin C-terminal SIMPL PF04402.14 CCF50615.1 - 0.89 10.0 3.3 2.8 8.3 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF541) E1_dh PF00676.20 CCF50616.1 - 2.5e-110 368.1 0.3 3e-110 367.9 0.3 1.0 1 0 0 1 1 1 1 Dehydrogenase E1 component DXP_synthase_N PF13292.6 CCF50616.1 - 0.00063 19.0 0.1 0.0011 18.3 0.1 1.3 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase TPP_enzyme_C PF02775.21 CCF50616.1 - 0.0021 17.9 6.3 0.0033 17.2 3.4 2.2 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain NADH_B2 PF14813.6 CCF50617.1 - 3.3e-05 23.6 1.0 4.4e-05 23.2 1.0 1.2 1 0 0 1 1 1 1 NADH dehydrogenase 1 beta subcomplex subunit 2 SWIRM-assoc_2 PF16496.5 CCF50618.1 - 2.5e-33 115.6 0.3 1.5e-32 113.0 0.3 2.2 1 1 0 1 1 1 1 SWIRM-associated domain at the N-terminal SWIRM PF04433.17 CCF50618.1 - 2.6e-31 107.8 0.0 1.3e-30 105.6 0.1 2.1 2 0 0 2 2 2 1 SWIRM domain SWIRM-assoc_1 PF16495.5 CCF50618.1 - 1.5e-28 98.6 9.2 4.4e-28 97.1 9.2 1.9 1 0 0 1 1 1 1 SWIRM-associated region 1 Myb_DNA-binding PF00249.31 CCF50618.1 - 3.4e-10 40.0 0.0 7.2e-10 38.9 0.0 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain ZZ PF00569.17 CCF50618.1 - 4.6e-09 35.9 3.4 8e-09 35.2 3.4 1.3 1 0 0 1 1 1 1 Zinc finger, ZZ type Myb_DNA-bind_6 PF13921.6 CCF50618.1 - 1e-07 32.1 0.0 6.1e-06 26.4 0.0 2.6 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 CCF50618.1 - 0.013 15.4 0.0 0.045 13.6 0.0 1.9 1 0 0 1 1 1 0 Myb DNA-binding like Cyclin_N2 PF16500.5 CCF50618.1 - 0.78 10.5 6.8 0.36 11.6 3.5 2.2 2 0 0 2 2 2 0 N-terminal region of cyclin_N PhoD PF09423.10 CCF50619.1 - 1.6e-35 122.7 1.5 1.6e-35 122.7 1.5 1.9 2 1 0 2 2 2 1 PhoD-like phosphatase CytochromB561_N PF09786.9 CCF50619.1 - 0.001 18.2 2.7 0.0016 17.6 2.7 1.1 1 0 0 1 1 1 1 Cytochrome B561, N terminal TEBP_beta PF07404.11 CCF50619.1 - 3.4 6.9 7.6 29 3.9 0.0 2.4 2 0 0 2 2 2 0 Telomere-binding protein beta subunit (TEBP beta) His_biosynth PF00977.21 CCF50620.1 - 2.9e-40 138.1 0.1 2.2e-24 86.2 0.1 2.8 2 1 0 2 2 2 2 Histidine biosynthesis protein GATase PF00117.28 CCF50620.1 - 3.6e-16 59.5 0.0 6e-16 58.8 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I SNO PF01174.19 CCF50620.1 - 4e-07 30.1 0.0 2.1e-05 24.4 0.0 2.3 2 0 0 2 2 2 1 SNO glutamine amidotransferase family GATase_3 PF07685.14 CCF50620.1 - 1.6e-06 27.9 0.0 3.8e-06 26.6 0.0 1.6 2 0 0 2 2 2 1 CobB/CobQ-like glutamine amidotransferase domain Peptidase_C26 PF07722.13 CCF50620.1 - 0.067 12.9 0.0 0.95 9.2 0.0 2.2 2 0 0 2 2 2 0 Peptidase C26 PBP PF01161.20 CCF50620.1 - 0.082 13.2 0.2 0.16 12.3 0.2 1.4 1 0 0 1 1 1 0 Phosphatidylethanolamine-binding protein Asp PF00026.23 CCF50622.1 - 7.5e-47 160.3 0.0 1.1e-46 159.7 0.0 1.2 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 CCF50622.1 - 1.4e-15 58.0 1.6 1.1e-13 51.8 2.7 2.9 2 1 0 2 2 2 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 CCF50622.1 - 2.2e-05 25.0 0.0 0.12 13.0 0.0 3.8 3 1 0 3 3 3 2 Aspartyl protease TAXi_C PF14541.6 CCF50622.1 - 0.002 17.9 0.0 0.0042 16.9 0.0 1.4 1 0 0 1 1 1 1 Xylanase inhibitor C-terminal ABC_membrane PF00664.23 CCF50623.1 - 3.1e-48 164.8 22.1 3.5e-28 99.0 4.0 3.6 4 0 0 4 4 3 3 ABC transporter transmembrane region ABC_tran PF00005.27 CCF50623.1 - 5.4e-44 150.0 0.0 6.7e-25 88.2 0.0 2.7 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 CCF50623.1 - 1.2e-09 37.9 0.0 0.00021 20.8 0.2 4.1 2 2 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CCF50623.1 - 1.5e-05 24.7 0.1 0.089 12.5 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_25 PF13481.6 CCF50623.1 - 0.00013 21.6 0.1 0.055 13.0 0.0 3.2 3 0 0 3 3 3 1 AAA domain AAA_22 PF13401.6 CCF50623.1 - 0.00014 22.1 0.5 0.95 9.7 0.0 3.5 3 0 0 3 3 3 2 AAA domain AAA_24 PF13479.6 CCF50623.1 - 0.00035 20.4 0.1 0.015 15.0 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_23 PF13476.6 CCF50623.1 - 0.00052 20.6 0.0 0.96 9.9 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 CCF50623.1 - 0.0006 20.2 2.8 0.67 10.3 0.2 3.5 2 2 0 2 2 2 2 AAA ATPase domain AAA_21 PF13304.6 CCF50623.1 - 0.00067 19.6 0.5 9.6 5.9 0.1 3.5 3 0 0 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system T2SSE PF00437.20 CCF50623.1 - 0.0014 17.7 0.0 0.16 11.0 0.1 2.4 2 0 0 2 2 2 1 Type II/IV secretion system protein cobW PF02492.19 CCF50623.1 - 0.0081 15.8 2.6 0.029 13.9 0.5 2.5 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_30 PF13604.6 CCF50623.1 - 0.0086 15.8 0.1 0.28 10.9 0.1 2.9 2 1 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 CCF50623.1 - 0.013 15.6 0.2 1.6 8.8 0.0 2.7 2 0 0 2 2 2 0 50S ribosome-binding GTPase NACHT PF05729.12 CCF50623.1 - 0.015 15.2 0.8 1.1 9.2 0.2 2.7 2 0 0 2 2 2 0 NACHT domain SbcCD_C PF13558.6 CCF50623.1 - 0.017 15.4 0.1 4 7.7 0.0 2.8 2 0 0 2 2 2 0 Putative exonuclease SbcCD, C subunit DEAD PF00270.29 CCF50623.1 - 0.022 14.5 0.0 10 5.9 0.0 3.3 3 0 0 3 3 3 0 DEAD/DEAH box helicase RsgA_GTPase PF03193.16 CCF50623.1 - 0.061 13.2 0.1 2.5 8.0 0.1 2.4 2 0 0 2 2 2 0 RsgA GTPase NB-ARC PF00931.22 CCF50623.1 - 0.061 12.5 0.2 3.4 6.8 0.0 2.3 2 0 0 2 2 2 0 NB-ARC domain AAA_33 PF13671.6 CCF50623.1 - 0.073 13.2 0.9 2.9 8.0 0.2 2.7 2 0 0 2 2 2 0 AAA domain DUF2569 PF10754.9 CCF50623.1 - 0.074 13.5 9.9 0.02 15.3 3.4 3.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2569) DUF87 PF01935.17 CCF50623.1 - 0.1 12.6 0.2 0.38 10.8 0.0 2.0 2 0 0 2 2 2 0 Helicase HerA, central domain FtsK_SpoIIIE PF01580.18 CCF50623.1 - 0.14 11.5 0.2 18 4.6 0.2 2.4 2 0 0 2 2 2 0 FtsK/SpoIIIE family Zeta_toxin PF06414.12 CCF50623.1 - 0.15 11.3 0.1 19 4.5 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin ATP_bind_1 PF03029.17 CCF50623.1 - 0.22 11.2 3.1 3.4 7.4 0.2 3.1 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein NTPase_1 PF03266.15 CCF50623.1 - 0.44 10.5 2.2 26 4.7 0.2 3.1 3 0 0 3 3 3 0 NTPase AAA_18 PF13238.6 CCF50623.1 - 0.47 11.0 1.4 20 5.7 0.3 2.8 2 0 0 2 2 2 0 AAA domain Oleosin PF01277.17 CCF50623.1 - 5.6 6.8 8.2 91 2.8 6.6 3.1 2 0 0 2 2 2 0 Oleosin VHS PF00790.19 CCF50624.1 - 2.3e-37 128.0 3.4 7.8e-37 126.3 0.0 2.4 2 0 0 2 2 2 1 VHS domain FYVE PF01363.21 CCF50624.1 - 6.1e-17 61.5 10.4 1.4e-16 60.4 10.4 1.6 1 0 0 1 1 1 1 FYVE zinc finger UIM PF02809.20 CCF50624.1 - 2.8e-05 23.7 5.4 0.049 13.6 0.6 2.5 2 0 0 2 2 2 2 Ubiquitin interaction motif FYVE_2 PF02318.16 CCF50624.1 - 0.0035 17.5 3.4 0.0035 17.5 3.4 1.7 2 0 0 2 2 2 1 FYVE-type zinc finger zf-RING_5 PF14634.6 CCF50624.1 - 5.9 6.9 10.6 11 6.1 10.6 1.4 1 0 0 1 1 1 0 zinc-RING finger domain RNA_pol_Rpb1_1 PF04997.12 CCF50625.1 - 9.4e-105 350.4 0.0 1.3e-104 349.9 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_5 PF04998.17 CCF50625.1 - 8e-104 346.8 0.2 1.1e-103 346.4 0.2 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 CCF50625.1 - 5.5e-72 241.4 0.0 1.2e-71 240.3 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_6 PF04992.14 CCF50625.1 - 5e-60 202.6 0.1 1.1e-59 201.5 0.1 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 6 RNA_pol_Rpb1_7 PF04990.12 CCF50625.1 - 1.9e-47 160.6 1.1 4.1e-47 159.5 1.1 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 7 RNA_pol_Rpb1_3 PF04983.18 CCF50625.1 - 2.6e-45 154.2 0.0 5e-45 153.3 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.17 CCF50625.1 - 1.1e-35 121.8 0.0 2.6e-35 120.6 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_R PF05001.13 CCF50625.1 - 1.2e-19 69.5 191.3 0.0047 17.2 10.9 14.0 9 2 4 15 15 15 13 RNA polymerase Rpb1 C-terminal repeat DUF5616 PF18481.1 CCF50625.1 - 0.098 13.0 0.6 0.35 11.2 0.0 2.1 3 0 0 3 3 3 0 Domain of unknown function (DUF5616) NmrA PF05368.13 CCF50626.1 - 0.0001 22.0 0.0 0.00014 21.5 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family RhoGAP PF00620.27 CCF50627.1 - 3.3e-47 160.1 1.7 5.1e-46 156.3 0.0 2.6 2 0 0 2 2 2 1 RhoGAP domain LIM PF00412.22 CCF50627.1 - 2.8e-14 53.1 31.6 7.5e-09 35.7 3.1 3.4 3 0 0 3 3 3 2 LIM domain C1_1 PF00130.22 CCF50627.1 - 4.3e-07 29.7 8.2 4.3e-07 29.7 8.2 4.0 3 1 1 4 4 4 1 Phorbol esters/diacylglycerol binding domain (C1 domain) DUF3450 PF11932.8 CCF50627.1 - 0.0032 16.8 0.7 0.0032 16.8 0.7 2.7 2 0 0 2 2 2 1 Protein of unknown function (DUF3450) Prominin PF05478.11 CCF50627.1 - 0.079 10.9 9.8 0.034 12.1 6.9 1.8 1 1 0 1 1 1 0 Prominin Rotamase_2 PF13145.6 CCF50627.1 - 0.37 11.6 5.3 1.5 9.7 0.7 3.3 3 0 0 3 3 3 0 PPIC-type PPIASE domain Suppressor_APC PF11414.8 CCF50627.1 - 4.9 7.3 11.1 0.12 12.4 2.6 2.5 2 1 0 2 2 2 0 Adenomatous polyposis coli tumour suppressor protein Ras PF00071.22 CCF50628.1 - 5.5e-66 221.1 0.0 6.8e-66 220.9 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CCF50628.1 - 1.2e-33 115.9 0.1 2e-33 115.1 0.1 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CCF50628.1 - 5.6e-14 52.0 0.0 7.1e-14 51.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 CCF50628.1 - 8.1e-06 25.4 0.0 9.2e-06 25.2 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 CCF50628.1 - 2.7e-05 23.8 0.2 6.7e-05 22.5 0.1 1.7 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 CCF50628.1 - 3.7e-05 23.8 0.0 0.00013 22.0 0.0 1.7 1 1 1 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CCF50628.1 - 5.9e-05 23.0 0.0 0.28 11.1 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase FeoB_N PF02421.18 CCF50628.1 - 0.00055 19.5 0.0 0.0053 16.3 0.0 2.1 1 1 0 1 1 1 1 Ferrous iron transport protein B SRPRB PF09439.10 CCF50628.1 - 0.00092 18.7 0.0 0.0012 18.3 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MCM PF00493.23 CCF50628.1 - 0.014 14.5 0.0 0.32 10.1 0.0 2.1 2 0 0 2 2 2 0 MCM P-loop domain AAA_16 PF13191.6 CCF50628.1 - 0.015 15.6 0.0 0.023 15.1 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain AAA_29 PF13555.6 CCF50628.1 - 0.042 13.6 0.0 0.14 11.9 0.0 1.9 1 0 0 1 1 1 0 P-loop containing region of AAA domain NACHT PF05729.12 CCF50628.1 - 0.056 13.4 0.0 0.1 12.5 0.0 1.4 1 0 0 1 1 1 0 NACHT domain Septin PF00735.18 CCF50628.1 - 0.078 12.2 0.0 0.15 11.3 0.0 1.5 1 0 0 1 1 1 0 Septin AAA PF00004.29 CCF50628.1 - 0.079 13.4 0.0 0.58 10.6 0.0 2.0 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 CCF50628.1 - 0.14 12.1 0.0 0.46 10.5 0.0 1.8 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 CCF50628.1 - 0.17 12.2 0.0 0.81 10.0 0.0 2.0 1 1 1 2 2 2 0 AAA domain U3_assoc_6 PF08640.11 CCF50629.1 - 2.7e-21 75.4 0.1 2e-19 69.4 0.0 2.8 2 0 0 2 2 2 1 U3 small nucleolar RNA-associated protein 6 REV1_C PF16727.5 CCF50629.1 - 0.024 15.0 0.8 0.11 12.9 0.5 2.3 1 1 0 1 1 1 0 DNA repair protein REV1 C-terminal domain L27_1 PF09058.10 CCF50629.1 - 0.054 13.5 0.2 0.31 11.0 0.2 2.4 1 0 0 1 1 1 0 L27_1 TPR_14 PF13428.6 CCF50629.1 - 0.27 12.1 6.1 1.7 9.6 0.3 4.8 2 1 2 4 4 4 0 Tetratricopeptide repeat SPX PF03105.19 CCF50629.1 - 1.1 9.1 13.3 0.68 9.8 0.5 2.5 2 1 0 2 2 2 0 SPX domain ATP11 PF06644.11 CCF50630.1 - 2.1e-74 250.8 0.5 2.8e-74 250.3 0.5 1.2 1 0 0 1 1 1 1 ATP11 protein SinI PF08671.10 CCF50630.1 - 0.013 15.3 0.4 0.23 11.3 0.0 2.4 2 0 0 2 2 2 0 Anti-repressor SinI Nefa_Nip30_N PF10187.9 CCF50630.1 - 1.3 9.4 7.0 0.25 11.7 1.7 2.2 2 0 0 2 2 2 0 N-terminal domain of NEFA-interacting nuclear protein NIP30 MFS_1 PF07690.16 CCF50632.1 - 7.7e-22 77.7 43.7 2.2e-15 56.5 28.7 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF1449 PF07290.11 CCF50632.1 - 0.027 14.1 0.3 0.027 14.1 0.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1449) DUF3593 PF12159.8 CCF50632.1 - 0.16 12.1 2.5 9.9 6.3 0.1 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3593) HA2 PF04408.23 CCF50633.1 - 7.1e-15 55.2 2.1 9.5e-15 54.8 0.1 2.3 2 0 0 2 2 2 1 Helicase associated domain (HA2) Helicase_C PF00271.31 CCF50633.1 - 1.1e-14 54.7 0.0 3e-14 53.3 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain OB_NTP_bind PF07717.16 CCF50633.1 - 1.8e-11 44.3 0.0 3.8e-11 43.2 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold DEAD PF00270.29 CCF50633.1 - 1e-10 41.7 0.0 1.9e-10 40.8 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 CCF50633.1 - 0.00017 21.8 0.1 0.00056 20.2 0.1 1.8 1 0 0 1 1 1 1 AAA domain ResIII PF04851.15 CCF50633.1 - 0.0015 18.6 0.0 0.004 17.2 0.0 1.6 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit ATPase PF06745.13 CCF50633.1 - 0.0043 16.4 0.0 0.0094 15.3 0.0 1.5 1 0 0 1 1 1 1 KaiC T2SSE PF00437.20 CCF50633.1 - 0.05 12.6 0.0 0.1 11.7 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein ABC_tran PF00005.27 CCF50633.1 - 0.14 12.7 0.0 2.1 8.9 0.0 2.5 2 0 0 2 2 2 0 ABC transporter NACHT PF05729.12 CCF50633.1 - 0.16 11.9 0.0 0.5 10.3 0.0 1.9 1 0 0 1 1 1 0 NACHT domain DUF494 PF04361.13 CCF50633.1 - 0.16 11.8 0.2 0.91 9.4 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF494) RsgA_GTPase PF03193.16 CCF50633.1 - 0.17 11.8 0.0 0.54 10.1 0.0 1.8 1 0 0 1 1 1 0 RsgA GTPase AAA_16 PF13191.6 CCF50633.1 - 0.87 9.9 4.5 1.6 9.0 0.1 3.3 3 0 0 3 3 3 0 AAA ATPase domain Myosin_head PF00063.21 CCF50634.1 - 5.6e-240 798.2 4.5 7e-240 797.9 4.5 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_TH1 PF06017.13 CCF50634.1 - 9.9e-50 168.8 0.0 1.8e-49 167.9 0.0 1.5 1 0 0 1 1 1 1 Unconventional myosin tail, actin- and lipid-binding SH3_1 PF00018.28 CCF50634.1 - 1.7e-11 43.5 0.4 4.8e-11 42.1 0.2 1.9 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 CCF50634.1 - 1.5e-09 37.6 0.0 3.4e-09 36.4 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 CCF50634.1 - 6.6e-08 32.1 0.0 8.2e-07 28.6 0.0 2.6 2 0 0 2 2 2 1 Variant SH3 domain AAA_22 PF13401.6 CCF50634.1 - 0.025 14.8 0.0 0.099 12.9 0.0 2.0 1 0 0 1 1 1 0 AAA domain APS_kinase PF01583.20 CCF50634.1 - 0.053 13.4 0.2 0.68 9.8 0.0 2.4 2 1 0 2 2 2 0 Adenylylsulphate kinase Hpr_kinase_C PF07475.12 CCF50634.1 - 0.08 12.5 0.6 9.1 5.8 0.0 2.7 2 0 0 2 2 2 0 HPr Serine kinase C-terminal domain AAA_16 PF13191.6 CCF50634.1 - 0.085 13.2 0.0 0.31 11.4 0.0 1.9 1 0 0 1 1 1 0 AAA ATPase domain NACHT PF05729.12 CCF50634.1 - 0.13 12.1 0.0 0.32 10.9 0.0 1.6 1 0 0 1 1 1 0 NACHT domain IQ PF00612.27 CCF50634.1 - 3.2 7.8 7.3 7.7 6.6 0.5 2.7 1 1 1 2 2 2 0 IQ calmodulin-binding motif HMGL-like PF00682.19 CCF50635.1 - 1.8e-81 273.6 0.9 2.6e-81 273.1 0.9 1.2 1 0 0 1 1 1 1 HMGL-like FtsX_ECD PF18075.1 CCF50635.1 - 0.1 13.2 0.4 0.3 11.7 0.4 1.7 1 0 0 1 1 1 0 FtsX extracellular domain OTU PF02338.19 CCF50636.1 - 6.3e-26 91.4 0.0 1.1e-25 90.6 0.0 1.4 1 0 0 1 1 1 1 OTU-like cysteine protease Mak16 PF04874.14 CCF50636.1 - 0.0038 17.8 5.7 0.0083 16.7 5.7 1.5 1 0 0 1 1 1 1 Mak16 protein C-terminal region DUF3885 PF13021.6 CCF50638.1 - 0.17 12.0 0.0 0.43 10.7 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3885) Inv-AAD PF18785.1 CCF50639.1 - 7e-29 100.3 0.4 5.1e-24 84.6 0.1 2.2 1 1 1 2 2 2 2 Invertebrate-AID/APOBEC-deaminase dCMP_cyt_deam_1 PF00383.23 CCF50639.1 - 2.6e-11 43.3 0.3 9.5e-11 41.5 0.3 1.9 1 1 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region PAP2 PF01569.21 CCF50639.1 - 4.7e-11 42.6 4.9 4.7e-11 42.6 4.9 2.3 2 1 0 2 2 2 1 PAP2 superfamily APOBEC_N PF08210.11 CCF50639.1 - 0.0013 18.6 0.3 0.0021 18.0 0.3 1.4 1 0 0 1 1 1 1 APOBEC-like N-terminal domain Polysacc_synt_C PF14667.6 CCF50639.1 - 0.01 15.9 3.3 0.021 14.9 3.3 1.4 1 1 0 1 1 1 0 Polysaccharide biosynthesis C-terminal domain DUF212 PF02681.14 CCF50639.1 - 0.013 15.6 0.0 4.1 7.6 0.0 2.5 2 0 0 2 2 2 0 Divergent PAP2 family SNAD4 PF18750.1 CCF50639.1 - 0.024 14.7 0.1 0.059 13.5 0.1 1.6 1 0 0 1 1 1 0 Secreted Novel AID/APOBEC-like Deaminase 4 UbiA PF01040.18 CCF50639.1 - 4.4 6.5 11.4 0.34 10.2 5.0 2.2 2 1 0 2 2 2 0 UbiA prenyltransferase family EamA PF00892.20 CCF50640.1 - 3.2e-22 79.2 31.5 1.6e-12 47.8 4.8 2.3 2 0 0 2 2 2 2 EamA-like transporter family DUF5536 PF17688.1 CCF50640.1 - 0.036 13.9 1.1 0.43 10.5 0.2 2.8 3 0 0 3 3 3 0 Family of unknown function (DUF5536) DUF5337 PF17272.2 CCF50640.1 - 1.1 9.1 6.1 2.8 7.8 0.1 3.0 2 0 0 2 2 2 0 Family of unknown function (DUF5337) RseC_MucC PF04246.12 CCF50640.1 - 6.7 6.7 14.4 1.4 8.9 0.9 3.6 3 1 0 3 3 3 0 Positive regulator of sigma(E), RseC/MucC Bac_rhodopsin PF01036.18 CCF50642.1 - 3.9e-40 137.8 16.9 5.2e-40 137.4 16.9 1.0 1 0 0 1 1 1 1 Bacteriorhodopsin-like protein Arteri_Gl PF00951.18 CCF50642.1 - 0.21 11.4 10.9 0.023 14.5 5.8 2.0 2 0 0 2 2 2 0 Arterivirus GL envelope glycoprotein DUF3810 PF12725.7 CCF50642.1 - 7.5 5.8 5.8 7.5 5.8 4.6 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3810) HEM4 PF02602.15 CCF50643.1 - 7.1e-18 64.8 0.0 1.5e-10 40.9 0.0 3.3 2 1 1 3 3 3 3 Uroporphyrinogen-III synthase HemD 3Beta_HSD PF01073.19 CCF50644.1 - 1.7e-59 201.1 0.0 7.7e-54 182.6 0.0 2.5 2 1 0 2 2 2 2 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 CCF50644.1 - 6.8e-24 84.7 0.0 1.1e-23 84.0 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CCF50644.1 - 2.2e-12 47.0 0.0 1.6e-09 37.6 0.0 2.4 2 0 0 2 2 2 2 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 CCF50644.1 - 9e-08 31.6 0.0 1.6e-07 30.7 0.0 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_4 PF07993.12 CCF50644.1 - 2.2e-07 30.3 0.3 1.6e-06 27.5 0.0 2.1 1 1 1 2 2 2 1 Male sterility protein Polysacc_synt_2 PF02719.15 CCF50644.1 - 6.2e-05 22.3 0.1 0.00038 19.7 0.0 1.9 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.6 CCF50644.1 - 0.00027 20.9 0.1 0.00051 20.0 0.1 1.4 1 0 0 1 1 1 1 NAD(P)H-binding TrkA_N PF02254.18 CCF50644.1 - 0.0032 17.7 0.0 0.0067 16.7 0.0 1.5 1 0 0 1 1 1 1 TrkA-N domain ELFV_dehydrog PF00208.21 CCF50644.1 - 0.023 14.4 0.0 0.042 13.6 0.0 1.3 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase KR PF08659.10 CCF50644.1 - 0.11 12.4 0.2 0.48 10.3 0.2 2.0 1 1 0 1 1 1 0 KR domain Aminotran_5 PF00266.19 CCF50645.1 - 5.9e-18 65.0 0.0 9.2e-18 64.3 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.21 CCF50645.1 - 5.3e-06 25.9 0.0 9.1e-06 25.1 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II SNF2_N PF00176.23 CCF50646.1 - 2.9e-63 213.7 0.4 1.6e-62 211.3 0.0 2.0 2 0 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 CCF50646.1 - 1.2e-21 77.1 0.2 3.7e-21 75.6 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CCF50646.1 - 8.5e-11 42.1 0.0 5.2e-09 36.3 0.0 3.1 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 CCF50646.1 - 8.1e-07 28.5 0.0 8.1e-07 28.5 0.0 3.4 3 1 0 3 3 3 2 Class II histone deacetylase complex subunits 2 and 3 AT_hook PF02178.19 CCF50646.1 - 0.078 12.9 5.0 0.29 11.2 5.0 2.1 1 0 0 1 1 1 0 AT hook motif SNF2_N PF00176.23 CCF50648.1 - 4.4e-25 88.2 0.0 1.5e-14 53.5 0.0 2.3 2 0 0 2 2 2 2 SNF2 family N-terminal domain DNA_methylase PF00145.17 CCF50648.1 - 1e-12 48.1 0.8 1.4e-11 44.3 0.0 2.7 3 0 0 3 3 3 1 C-5 cytosine-specific DNA methylase Helicase_C PF00271.31 CCF50648.1 - 1.6e-05 25.2 0.0 3.3e-05 24.2 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 CCF50648.1 - 0.0013 18.8 0.0 0.22 11.5 0.0 3.3 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit DUF4315 PF14193.6 CCF50648.1 - 0.0043 17.0 0.2 0.0043 17.0 0.2 2.6 2 0 0 2 2 2 1 Domain of unknown function (DUF4315) Activator-TraM PF11657.8 CCF50648.1 - 3.8 7.3 8.3 13 5.6 0.0 3.0 3 0 0 3 3 3 0 Transcriptional activator TraM SHQ1 PF04925.15 CCF50649.1 - 3.2e-26 92.0 0.0 4.8e-26 91.4 0.0 1.2 1 0 0 1 1 1 1 SHQ1 protein HTH_35 PF13693.6 CCF50649.1 - 0.048 13.7 0.1 2.1 8.4 0.1 3.0 2 1 1 3 3 3 0 Winged helix-turn-helix DNA-binding WAPL PF07814.13 CCF50650.1 - 4.9e-09 35.5 5.3 2.3e-08 33.2 0.0 2.9 3 1 1 4 4 4 2 Wings apart-like protein regulation of heterochromatin Sigma70_ner PF04546.13 CCF50650.1 - 2.2 8.1 7.5 8.1 6.3 0.3 2.7 2 0 0 2 2 2 0 Sigma-70, non-essential region BIR PF00653.21 CCF50651.1 - 4.3e-30 104.2 0.6 2.5e-23 82.5 1.0 2.6 2 0 0 2 2 2 2 Inhibitor of Apoptosis domain zf-BED PF02892.15 CCF50651.1 - 0.0035 17.3 0.1 0.009 16.0 0.1 1.6 1 0 0 1 1 1 1 BED zinc finger PGA_cap PF09587.10 CCF50651.1 - 1.3 8.4 4.9 3.3 7.1 4.9 1.7 1 0 0 1 1 1 0 Bacterial capsule synthesis protein PGA_cap Pkinase PF00069.25 CCF50652.1 - 7.1e-57 192.8 0.0 9.4e-57 192.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF50652.1 - 4.4e-27 95.0 0.0 6.2e-27 94.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCF50652.1 - 0.0081 15.5 0.0 0.015 14.6 0.0 1.5 1 0 0 1 1 1 1 Kinase-like DUF5512 PF17631.2 CCF50652.1 - 0.075 13.0 0.1 0.17 11.9 0.1 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5512) FTA2 PF13095.6 CCF50652.1 - 0.081 12.5 0.0 2.3 7.8 0.0 2.3 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 CCF50652.1 - 0.49 10.3 4.2 2.2 8.1 0.3 2.8 2 1 1 3 3 3 0 Phosphotransferase enzyme family Pro_isomerase PF00160.21 CCF50654.1 - 5.3e-47 160.0 0.1 6.1e-47 159.8 0.1 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TAL_FSA PF00923.19 CCF50655.1 - 1e-96 323.7 1.6 1.2e-96 323.5 1.6 1.0 1 0 0 1 1 1 1 Transaldolase/Fructose-6-phosphate aldolase GA PF01468.17 CCF50655.1 - 0.036 14.3 0.8 0.098 12.9 0.8 1.6 1 0 0 1 1 1 0 GA module UreD PF01774.17 CCF50656.1 - 3.2e-69 233.1 0.0 5.7e-69 232.3 0.0 1.4 1 0 0 1 1 1 1 UreD urease accessory protein EI24 PF07264.11 CCF50656.1 - 5.2e-07 30.1 8.9 1.2e-06 28.9 8.9 1.6 1 1 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) DUF502 PF04367.13 CCF50656.1 - 0.075 12.9 0.0 0.17 11.8 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF502) Trans_reg_C PF00486.28 CCF50656.1 - 0.13 12.4 0.0 0.3 11.2 0.0 1.5 1 0 0 1 1 1 0 Transcriptional regulatory protein, C terminal CorA PF01544.18 CCF50657.1 - 2.3e-08 33.7 3.9 1.2e-07 31.4 3.9 1.8 1 1 0 1 1 1 1 CorA-like Mg2+ transporter protein Keratin_2_head PF16208.5 CCF50657.1 - 2.5 8.2 25.8 0.05 13.7 16.5 2.3 2 0 0 2 2 2 0 Keratin type II head FH2 PF02181.23 CCF50658.1 - 4.2e-64 217.0 6.3 4.2e-64 217.0 6.3 2.3 2 0 0 2 2 2 1 Formin Homology 2 Domain Drf_GBD PF06371.13 CCF50658.1 - 1.7e-44 151.6 0.7 1.2e-43 148.9 0.0 2.3 2 0 0 2 2 2 1 Diaphanous GTPase-binding Domain Drf_FH3 PF06367.16 CCF50658.1 - 8.8e-43 146.2 1.0 3.6e-42 144.2 0.0 2.4 2 1 1 3 3 3 1 Diaphanous FH3 Domain CorA PF01544.18 CCF50658.1 - 0.36 10.1 10.7 0.82 8.9 0.3 2.5 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein HECT_2 PF09814.9 CCF50661.1 - 5.5e-17 61.7 0.0 6.2e-17 61.5 0.0 1.1 1 0 0 1 1 1 1 HECT-like Ubiquitin-conjugating enzyme (E2)-binding hNIFK_binding PF12196.8 CCF50662.1 - 0.055 13.0 0.1 0.17 11.4 0.1 1.8 1 0 0 1 1 1 0 FHA Ki67 binding domain of hNIFK eIF-3_zeta PF05091.12 CCF50662.1 - 0.095 11.7 14.6 0.2 10.6 14.6 1.4 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Folate_carrier PF01770.18 CCF50662.1 - 1.9 7.2 7.7 2.9 6.6 7.7 1.2 1 0 0 1 1 1 0 Reduced folate carrier LMBR1 PF04791.16 CCF50662.1 - 2.6 6.9 3.3 4 6.2 3.3 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein CRT10 PF08728.10 CCF50662.1 - 3.9 5.5 7.6 6.2 4.8 7.6 1.2 1 0 0 1 1 1 0 CRT10 EXS PF03124.14 CCF50663.1 - 4.5e-79 266.2 26.4 6.6e-79 265.6 26.4 1.3 1 0 0 1 1 1 1 EXS family SPX PF03105.19 CCF50663.1 - 1.6e-54 186.3 8.4 1.6e-54 186.3 8.4 2.4 2 1 0 2 2 2 1 SPX domain ParE_toxin PF05016.15 CCF50663.1 - 0.18 12.4 1.2 2.1 9.0 0.4 2.8 2 0 0 2 2 2 0 ParE toxin of type II toxin-antitoxin system, parDE PPP4R2 PF09184.11 CCF50663.1 - 2.4 7.7 17.1 0.064 12.8 9.9 2.0 2 0 0 2 2 2 0 PPP4R2 RNA_pol_3_Rpc31 PF11705.8 CCF50663.1 - 3 8.0 22.5 0.25 11.6 17.2 1.9 2 0 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 DUF4746 PF15928.5 CCF50663.1 - 6.1 6.2 12.2 13 5.1 12.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) TFB6 PF17110.5 CCF50663.1 - 8.1 6.2 6.3 21 4.8 6.3 1.7 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH Exo84_C PF16528.5 CCF50664.1 - 9.8e-51 172.5 0.2 1.7e-50 171.7 0.2 1.4 1 0 0 1 1 1 1 Exocyst component 84 C-terminal Vps51 PF08700.11 CCF50664.1 - 1.1e-17 63.8 2.0 2e-17 63.1 0.4 2.3 2 0 0 2 2 2 1 Vps51/Vps67 COG2 PF06148.11 CCF50664.1 - 0.0015 18.6 2.2 0.0019 18.3 0.1 2.3 3 0 0 3 3 3 1 COG (conserved oligomeric Golgi) complex component, COG2 Ribosomal_S15 PF00312.22 CCF50665.1 - 3.8e-26 91.1 0.7 8.3e-26 90.0 0.7 1.6 1 0 0 1 1 1 1 Ribosomal protein S15 PPK2 PF03976.14 CCF50665.1 - 0.042 13.4 0.1 0.091 12.3 0.1 1.5 1 0 0 1 1 1 0 Polyphosphate kinase 2 (PPK2) RRM_1 PF00076.22 CCF50666.1 - 7.8e-14 51.3 0.0 1.3e-13 50.5 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 CCF50666.1 - 0.0025 17.4 0.0 0.0048 16.5 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CCF50666.1 - 0.05 13.7 0.0 0.084 13.0 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif RL PF17797.1 CCF50666.1 - 0.11 12.5 0.1 0.19 11.7 0.1 1.3 1 0 0 1 1 1 0 RL domain rve PF00665.26 CCF50667.1 - 3.4e-11 43.4 0.1 6.8e-11 42.4 0.1 1.4 1 0 0 1 1 1 1 Integrase core domain gag_pre-integrs PF13976.6 CCF50667.1 - 2.6e-06 27.2 0.4 6.4e-06 25.9 0.4 1.7 1 0 0 1 1 1 1 GAG-pre-integrase domain DUF3391 PF11871.8 CCF50667.1 - 0.15 12.6 0.1 0.25 11.9 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3391) Dopey_N PF04118.14 CCF50668.1 - 6.5e-107 357.2 0.1 1.7e-106 355.8 0.1 1.8 1 0 0 1 1 1 1 Dopey, N-terminal Bundlin PF05307.11 CCF50668.1 - 0.14 12.0 0.0 0.39 10.6 0.0 1.7 1 0 0 1 1 1 0 Bundlin TFIIA PF03153.13 CCF50670.1 - 0.11 12.4 52.2 0.13 12.2 52.2 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PCM1_C PF15717.5 CCF50670.1 - 0.13 10.9 31.6 0.16 10.6 31.6 1.0 1 0 0 1 1 1 0 Pericentriolar material 1 C terminus SOBP PF15279.6 CCF50670.1 - 0.14 12.8 23.7 0.16 12.6 23.7 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein Rib_5-P_isom_A PF06026.14 CCF50673.1 - 1.4e-60 203.9 0.0 1.8e-60 203.5 0.0 1.2 1 0 0 1 1 1 1 Ribose 5-phosphate isomerase A (phosphoriboisomerase A) DeoRC PF00455.22 CCF50673.1 - 0.0079 16.1 0.0 0.57 10.1 0.0 2.2 2 0 0 2 2 2 2 DeoR C terminal sensor domain NUC173 PF08161.12 CCF50674.1 - 2.5e-62 210.2 0.1 7e-61 205.4 0.0 2.8 3 0 0 3 3 3 1 NUC173 domain MMS19_C PF12460.8 CCF50674.1 - 0.00033 19.9 7.9 0.0082 15.3 0.3 3.5 3 0 0 3 3 3 2 RNAPII transcription regulator C-terminal DUF1018 PF06252.12 CCF50674.1 - 4.2 8.4 6.4 9.7 7.2 0.1 4.2 5 0 0 5 5 5 0 Protein of unknown function (DUF1018) SET PF00856.28 CCF50675.1 - 2.6e-08 34.4 0.0 1.1e-07 32.3 0.0 2.0 1 1 0 1 1 1 1 SET domain HMGL-like PF00682.19 CCF50676.1 - 1.4e-74 251.0 0.0 1.9e-74 250.6 0.0 1.2 1 0 0 1 1 1 1 HMGL-like LeuA_dimer PF08502.10 CCF50676.1 - 9.8e-20 70.8 1.6 1.8e-08 34.4 0.0 2.9 2 1 0 2 2 2 2 LeuA allosteric (dimerisation) domain DEAD_2 PF06733.15 CCF50677.1 - 1.1e-52 178.2 0.1 1.5e-46 158.3 0.0 2.4 2 0 0 2 2 2 2 DEAD_2 HBB PF06777.11 CCF50677.1 - 3.1e-45 154.2 0.8 7.5e-42 143.2 0.2 2.4 2 0 0 2 2 2 2 Helical and beta-bridge domain Helicase_C_2 PF13307.6 CCF50677.1 - 2.8e-44 151.3 0.0 6.7e-44 150.1 0.0 1.7 1 0 0 1 1 1 1 Helicase C-terminal domain ResIII PF04851.15 CCF50677.1 - 1.5e-05 25.0 0.0 0.0036 17.3 0.0 2.3 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit DEAD PF00270.29 CCF50677.1 - 0.002 17.9 0.2 0.25 11.1 0.0 2.7 3 0 0 3 3 3 1 DEAD/DEAH box helicase DUF968 PF06147.11 CCF50677.1 - 0.013 15.8 0.3 0.7 10.1 0.0 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF968) DUF2075 PF09848.9 CCF50677.1 - 0.027 13.7 0.2 1.8 7.7 0.0 2.3 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) rve PF00665.26 CCF50678.1 - 6.6e-08 32.8 0.1 1e-07 32.1 0.1 1.3 1 0 0 1 1 1 1 Integrase core domain RVT_2 PF07727.14 CCF50679.1 - 1.9e-14 53.9 0.2 2e-10 40.7 0.0 2.5 2 1 1 3 3 3 2 Reverse transcriptase (RNA-dependent DNA polymerase) ABC_tran PF00005.27 CCF50680.1 - 5.2e-45 153.3 0.9 9.5e-22 78.0 0.0 5.0 3 2 0 3 3 3 2 ABC transporter AAA_21 PF13304.6 CCF50680.1 - 1.5e-18 67.7 0.0 0.0014 18.5 0.0 4.3 4 0 0 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CCF50680.1 - 7.4e-14 51.7 1.4 0.018 14.5 0.0 4.3 4 0 0 4 4 4 4 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CCF50680.1 - 3.9e-09 36.1 0.5 0.0026 17.5 0.2 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_23 PF13476.6 CCF50680.1 - 2.1e-06 28.4 6.2 0.0075 16.8 0.0 3.6 5 0 0 5 5 3 2 AAA domain CLASP_N PF12348.8 CCF50680.1 - 3.8e-06 26.6 0.5 4.6e-05 23.1 0.1 2.7 3 1 0 3 3 1 1 CLASP N terminal AAA_22 PF13401.6 CCF50680.1 - 1.2e-05 25.6 0.0 0.39 11.0 0.0 4.1 5 0 0 5 5 3 2 AAA domain Chromo PF00385.24 CCF50680.1 - 2.3e-05 24.2 0.1 5.7e-05 22.9 0.1 1.7 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain MMR_HSR1 PF01926.23 CCF50680.1 - 2.9e-05 24.1 0.1 0.1 12.7 0.0 3.1 3 0 0 3 3 2 2 50S ribosome-binding GTPase AAA_30 PF13604.6 CCF50680.1 - 0.00013 21.7 0.1 5.9 6.6 0.0 3.6 3 0 0 3 3 3 0 AAA domain AAA PF00004.29 CCF50680.1 - 0.00024 21.5 0.0 2.9 8.3 0.0 4.9 5 1 0 5 5 4 1 ATPase family associated with various cellular activities (AAA) HEAT_2 PF13646.6 CCF50680.1 - 0.00026 21.3 0.2 1.2 9.6 0.0 3.7 2 1 1 3 3 3 2 HEAT repeats AAA_15 PF13175.6 CCF50680.1 - 0.00029 20.7 0.6 0.33 10.6 0.0 3.0 4 0 0 4 4 3 1 AAA ATPase domain AAA_5 PF07728.14 CCF50680.1 - 0.00035 20.6 3.0 3 7.9 0.0 5.1 5 0 0 5 5 5 1 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 CCF50680.1 - 0.00041 20.9 0.0 0.22 12.0 0.0 2.8 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 CCF50680.1 - 0.0005 20.0 0.1 1.1 9.1 0.0 2.9 3 0 0 3 3 2 2 NACHT domain DUF87 PF01935.17 CCF50680.1 - 0.00051 20.2 4.3 0.22 11.6 0.0 4.2 4 0 0 4 4 4 1 Helicase HerA, central domain RsgA_GTPase PF03193.16 CCF50680.1 - 0.0006 19.8 0.1 0.76 9.7 0.0 2.6 2 0 0 2 2 2 1 RsgA GTPase AAA_28 PF13521.6 CCF50680.1 - 0.00079 19.7 0.0 2.4 8.4 0.0 2.8 2 0 0 2 2 2 2 AAA domain 4HB PF17947.1 CCF50680.1 - 0.00081 19.4 0.0 0.0034 17.4 0.0 2.0 1 0 0 1 1 1 1 Four helical bundle domain DRIM PF07539.12 CCF50680.1 - 0.00088 17.7 0.5 0.19 10.0 0.1 2.5 1 1 1 3 3 3 1 Down-regulated in metastasis AAA_16 PF13191.6 CCF50680.1 - 0.001 19.5 0.3 0.59 10.5 0.0 3.6 3 1 0 3 3 3 1 AAA ATPase domain NB-ARC PF00931.22 CCF50680.1 - 0.0019 17.4 0.0 1 8.5 0.0 2.5 2 0 0 2 2 2 1 NB-ARC domain MeaB PF03308.16 CCF50680.1 - 0.0021 17.1 0.4 0.23 10.4 0.1 2.8 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_33 PF13671.6 CCF50680.1 - 0.0023 18.1 0.0 2.3 8.4 0.0 2.7 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 CCF50680.1 - 0.0026 18.1 0.0 5.3 7.5 0.0 2.8 2 0 0 2 2 2 0 RNA helicase DUF3584 PF12128.8 CCF50680.1 - 0.0031 15.1 1.0 0.38 8.2 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF3584) G-alpha PF00503.20 CCF50680.1 - 0.005 16.1 0.0 0.92 8.6 0.0 2.4 2 0 0 2 2 2 1 G-protein alpha subunit ATPase_2 PF01637.18 CCF50680.1 - 0.0068 16.3 1.7 7.3 6.4 0.2 3.7 3 1 0 3 3 3 0 ATPase domain predominantly from Archaea AAA_24 PF13479.6 CCF50680.1 - 0.0099 15.6 0.2 2 8.1 0.0 3.0 3 0 0 3 3 3 1 AAA domain SbcCD_C PF13558.6 CCF50680.1 - 0.012 15.8 0.1 0.83 9.9 0.0 3.6 2 2 0 2 2 2 0 Putative exonuclease SbcCD, C subunit EF-hand_7 PF13499.6 CCF50680.1 - 0.017 15.6 0.1 0.47 10.9 0.0 3.1 3 1 0 3 3 2 0 EF-hand domain pair UME PF08064.13 CCF50680.1 - 0.019 14.8 1.4 1.2 9.1 0.4 3.2 2 1 1 3 3 3 0 UME (NUC010) domain AAA_13 PF13166.6 CCF50680.1 - 0.023 13.4 0.0 2.2 6.8 0.0 2.6 3 0 0 3 3 2 0 AAA domain DUF815 PF05673.13 CCF50680.1 - 0.03 13.5 0.3 5.6 6.0 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF815) NTPase_1 PF03266.15 CCF50680.1 - 0.038 13.9 0.1 5.1 7.0 0.0 2.6 2 0 0 2 2 2 0 NTPase Roc PF08477.13 CCF50680.1 - 0.038 14.2 0.0 11 6.3 0.0 2.6 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase HEAT PF02985.22 CCF50680.1 - 0.043 14.1 1.5 2 8.9 0.0 4.3 4 0 0 4 4 3 0 HEAT repeat FtsK_SpoIIIE PF01580.18 CCF50680.1 - 0.056 12.8 0.2 9.2 5.5 0.0 2.6 2 0 0 2 2 2 0 FtsK/SpoIIIE family TFCD_C PF12612.8 CCF50680.1 - 0.065 13.1 0.0 1.5 8.7 0.0 2.8 2 0 0 2 2 2 0 Tubulin folding cofactor D C terminal ATP_bind_1 PF03029.17 CCF50680.1 - 0.13 12.0 0.6 8.6 6.1 0.1 2.6 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_7 PF12775.7 CCF50680.1 - 0.13 11.8 0.1 19 4.7 0.1 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region TsaE PF02367.17 CCF50680.1 - 0.13 12.2 0.2 27 4.8 0.0 3.0 3 0 0 3 3 3 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ABC_tran_Xtn PF12848.7 CCF50680.1 - 0.16 12.0 3.0 3.9 7.6 0.0 3.0 2 0 0 2 2 2 0 ABC transporter DUF3437 PF11919.8 CCF50680.1 - 0.19 11.7 0.2 6.3 6.8 0.1 3.1 3 0 0 3 3 2 0 Domain of unknown function (DUF3437) HEAT_EZ PF13513.6 CCF50680.1 - 0.23 12.0 1.3 86 3.8 0.0 4.9 4 2 1 5 5 4 0 HEAT-like repeat cobW PF02492.19 CCF50680.1 - 0.31 10.6 2.2 19 4.8 0.1 2.8 3 0 0 3 3 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_27 PF13514.6 CCF50680.1 - 0.51 9.9 3.1 9.8 5.7 0.0 3.0 3 0 0 3 3 3 0 AAA domain EHN PF06441.12 CCF50681.1 - 1.4e-24 86.5 0.1 1.2e-23 83.5 0.0 2.4 2 0 0 2 2 2 1 Epoxide hydrolase N terminus Abhydrolase_1 PF00561.20 CCF50681.1 - 2.7e-13 50.1 0.4 5.7e-13 49.1 0.4 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold Sec10 PF07393.11 CCF50684.1 - 2.6e-77 260.9 2.4 4.1e-76 256.9 0.0 3.0 3 1 0 3 3 3 1 Exocyst complex component Sec10 F-box PF00646.33 CCF50684.1 - 0.00064 19.5 0.1 0.0016 18.3 0.1 1.6 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 CCF50684.1 - 0.0038 17.1 0.3 0.01 15.7 0.3 1.7 1 0 0 1 1 1 1 F-box-like Spo7 PF03907.13 CCF50685.1 - 1.2e-45 155.7 2.2 2.1e-45 154.9 2.2 1.3 1 0 0 1 1 1 1 Spo7-like protein Tmemb_18A PF09771.9 CCF50685.1 - 3.2e-05 24.3 0.7 3.2e-05 24.3 0.7 2.0 2 0 0 2 2 2 1 Transmembrane protein 188 DUF2417 PF10329.9 CCF50685.1 - 0.046 13.1 0.5 0.074 12.5 0.5 1.4 1 0 0 1 1 1 0 Region of unknown function (DUF2417) ISK_Channel PF02060.15 CCF50685.1 - 2.4 7.9 3.7 1.8 8.3 0.1 2.2 1 1 1 2 2 2 0 Slow voltage-gated potassium channel RhoGEF PF00621.20 CCF50686.1 - 1.4e-24 87.3 0.0 2.3e-24 86.7 0.0 1.2 1 0 0 1 1 1 1 RhoGEF domain Rotamase PF00639.21 CCF50687.1 - 4.4 8.3 5.6 4.7 8.2 0.1 2.6 3 0 0 3 3 3 0 PPIC-type PPIASE domain Mito_carr PF00153.27 CCF50689.1 - 1e-58 195.2 2.0 2.4e-23 81.9 0.0 3.8 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF4604 PF15377.6 CCF50690.1 - 7.5e-30 104.6 27.5 1.2e-29 103.9 27.5 1.3 1 1 0 1 1 1 1 Domain of unknown function (DUF4604) DUF1378 PF07125.11 CCF50690.1 - 0.52 10.5 1.3 1 9.5 0.4 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1378) DUF1365 PF07103.11 CCF50691.1 - 4.1e-65 219.8 0.0 1.1e-64 218.4 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF1365) Rep_fac-A_3 PF08661.11 CCF50692.1 - 2e-28 98.8 0.0 2.2e-28 98.7 0.0 1.0 1 0 0 1 1 1 1 Replication factor A protein 3 She9_MDM33 PF05546.11 CCF50693.1 - 1.2e-65 221.1 12.9 1.8e-65 220.5 12.9 1.2 1 0 0 1 1 1 1 She9 / Mdm33 family HOIP-UBA PF16678.5 CCF50693.1 - 0.016 15.2 0.6 0.038 14.0 0.6 1.7 1 0 0 1 1 1 0 HOIP UBA domain pair Pox_A_type_inc PF04508.12 CCF50693.1 - 0.078 12.9 0.3 0.26 11.2 0.3 1.9 1 0 0 1 1 1 0 Viral A-type inclusion protein repeat AD PF09793.9 CCF50693.1 - 0.094 12.9 0.6 0.53 10.4 0.4 2.3 2 0 0 2 2 2 0 Anticodon-binding domain ATP-synt_D PF01813.17 CCF50694.1 - 2.2e-72 243.1 1.5 3.1e-72 242.5 1.5 1.2 1 0 0 1 1 1 1 ATP synthase subunit D MT PF12777.7 CCF50694.1 - 0.019 14.0 0.1 0.019 14.0 0.1 2.1 2 0 0 2 2 2 0 Microtubule-binding stalk of dynein motor Paf1 PF03985.13 CCF50694.1 - 0.41 9.6 13.0 0.61 9.0 13.0 1.2 1 0 0 1 1 1 0 Paf1 Zip PF02535.22 CCF50694.1 - 0.7 9.1 4.9 0.95 8.6 4.9 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Sec62 PF03839.16 CCF50694.1 - 1.5 8.3 17.9 2.8 7.4 17.9 1.4 1 0 0 1 1 1 0 Translocation protein Sec62 XRN_M PF17846.1 CCF50694.1 - 2.2 7.1 8.1 3.6 6.4 8.1 1.3 1 0 0 1 1 1 0 Xrn1 helical domain SLC12 PF03522.15 CCF50694.1 - 4.2 6.3 9.5 6.8 5.6 9.5 1.3 1 0 0 1 1 1 0 Solute carrier family 12 CDC45 PF02724.14 CCF50694.1 - 8.6 4.5 14.0 14 3.8 14.0 1.2 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 CCF50694.1 - 9.1 4.9 11.1 13 4.4 11.1 1.2 1 0 0 1 1 1 0 Presenilin WD40 PF00400.32 CCF50695.1 - 7.5e-14 51.9 8.1 0.017 16.0 0.0 7.0 7 0 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF50695.1 - 0.026 14.8 0.0 9.5 6.6 0.0 2.8 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain PQQ_3 PF13570.6 CCF50695.1 - 0.18 12.3 3.2 7.2 7.2 0.0 4.0 4 0 0 4 4 4 0 PQQ-like domain LETM1 PF07766.13 CCF50696.1 - 4.5e-103 344.2 2.2 4.5e-103 344.2 2.2 2.4 2 0 0 2 2 2 1 LETM1-like protein EF-hand_7 PF13499.6 CCF50696.1 - 1.4e-06 28.6 0.1 1.4e-06 28.6 0.1 3.5 4 0 0 4 4 4 1 EF-hand domain pair EF-hand_8 PF13833.6 CCF50696.1 - 3.2e-05 23.7 0.1 8.3e-05 22.4 0.1 1.8 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 CCF50696.1 - 0.0029 17.4 0.3 4.9 7.3 0.0 3.3 3 0 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.32 CCF50696.1 - 0.003 17.0 0.6 1.3 8.8 0.0 3.6 3 0 0 3 3 3 1 EF hand DUF1682 PF07946.14 CCF50696.1 - 0.014 14.6 6.7 0.041 13.1 6.7 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) RPA_C PF08784.11 CCF50696.1 - 0.21 12.3 1.9 0.32 11.7 0.1 2.2 2 0 0 2 2 2 0 Replication protein A C terminal Ins_allergen_rp PF06757.13 CCF50696.1 - 0.29 11.1 3.9 1.1 9.1 0.1 2.9 2 0 0 2 2 2 0 Insect allergen related repeat, nitrile-specifier detoxification DUF2497 PF10691.9 CCF50696.1 - 1.3 9.5 0.0 1.3 9.5 0.0 4.0 4 0 0 4 4 4 0 Protein of unknown function (DUF2497) TatD_DNase PF01026.21 CCF50697.1 - 4.2e-50 170.5 0.1 5e-50 170.3 0.1 1.1 1 0 0 1 1 1 1 TatD related DNase Rot1 PF10681.9 CCF50698.1 - 6.9e-61 205.4 2.9 8.3e-61 205.1 2.9 1.0 1 0 0 1 1 1 1 Chaperone for protein-folding within the ER, fungal Autophagy_act_C PF03987.15 CCF50698.1 - 0.039 14.5 0.9 0.1 13.2 0.9 1.7 1 0 0 1 1 1 0 Autophagocytosis associated protein, active-site domain p31comet PF06581.12 CCF50699.1 - 0.0011 18.2 1.2 0.068 12.3 0.4 2.8 4 0 0 4 4 4 2 Mad1 and Cdc20-bound-Mad2 binding APC_rep PF18797.1 CCF50699.1 - 0.0035 18.2 0.0 0.017 16.0 0.0 2.3 2 0 0 2 2 2 1 Adenomatous polyposis coli (APC) repeat DUF2508 PF10704.9 CCF50699.1 - 0.44 10.7 2.1 0.38 11.0 0.2 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2508) Coatomer_WDAD PF04053.14 CCF50700.1 - 3.6e-135 451.5 0.0 6.4e-135 450.7 0.0 1.4 2 0 0 2 2 2 1 Coatomer WD associated region COPI_C PF06957.11 CCF50700.1 - 7.8e-101 337.7 0.0 9.9e-101 337.4 0.0 1.1 1 0 0 1 1 1 1 Coatomer (COPI) alpha subunit C-terminus WD40 PF00400.32 CCF50700.1 - 5.2e-44 147.4 11.5 4.1e-08 33.8 0.4 7.6 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF50700.1 - 1.2e-12 48.0 0.1 0.0033 17.7 0.0 5.7 4 1 3 7 7 7 3 Anaphase-promoting complex subunit 4 WD40 domain Clathrin PF00637.20 CCF50700.1 - 0.031 14.2 0.1 0.13 12.2 0.0 2.0 2 0 0 2 2 2 0 Region in Clathrin and VPS Nucleoporin_N PF08801.11 CCF50700.1 - 0.084 11.6 0.1 0.86 8.3 0.0 2.5 2 1 0 2 2 2 0 Nup133 N terminal like Nup160 PF11715.8 CCF50700.1 - 0.31 9.6 6.1 1.4 7.5 0.0 3.5 2 1 2 4 4 4 0 Nucleoporin Nup120/160 DUF1712 PF08217.11 CCF50701.1 - 2.6e-08 32.9 0.0 4.6e-07 28.7 0.0 2.1 2 0 0 2 2 2 2 Fungal domain of unknown function (DUF1712) NADase_NGA PF07461.11 CCF50701.1 - 0.12 11.2 0.1 0.21 10.4 0.1 1.2 1 0 0 1 1 1 0 Nicotine adenine dinucleotide glycohydrolase (NADase) GDC-P PF02347.16 CCF50702.1 - 1.1e-182 607.7 0.0 1.6e-170 567.6 0.0 2.9 3 0 0 3 3 3 2 Glycine cleavage system P-protein Aminotran_5 PF00266.19 CCF50702.1 - 3e-05 23.2 0.1 6.9e-05 22.0 0.1 1.5 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 CCF50702.1 - 5.3e-05 22.6 0.0 0.00011 21.6 0.0 1.4 1 0 0 1 1 1 1 Beta-eliminating lyase tRNA_synthFbeta PF17759.1 CCF50703.1 - 5.8e-45 153.4 0.0 8.4e-45 152.8 0.0 1.2 1 0 0 1 1 1 1 Phenylalanyl tRNA synthetase beta chain CLM domain PhetRS_B1 PF18262.1 CCF50703.1 - 1.8e-31 108.2 0.0 4e-31 107.1 0.0 1.6 1 0 0 1 1 1 1 Phe-tRNA synthetase beta subunit B1 domain B3_4 PF03483.17 CCF50703.1 - 2.8e-26 92.2 0.0 4.6e-26 91.5 0.0 1.4 1 0 0 1 1 1 1 B3/4 domain B5 PF03484.15 CCF50703.1 - 1.8e-19 69.8 0.0 1.4e-16 60.6 0.0 2.5 2 0 0 2 2 2 2 tRNA synthetase B5 domain tRNA-synt_2d PF01409.20 CCF50703.1 - 0.17 11.4 0.0 2.9 7.3 0.0 2.3 2 0 0 2 2 2 0 tRNA synthetases class II core domain (F) EST1_DNA_bind PF10373.9 CCF50704.1 - 1.8e-31 109.7 0.6 2.4e-28 99.4 0.1 3.2 2 1 0 2 2 2 1 Est1 DNA/RNA binding domain EST1 PF10374.9 CCF50704.1 - 1.2e-23 84.3 0.2 1.2e-22 81.0 0.0 2.8 3 0 0 3 3 3 1 Telomerase activating protein Est1 Methyltrans_RNA PF04452.14 CCF50704.1 - 0.13 11.5 0.0 0.24 10.7 0.0 1.3 1 0 0 1 1 1 0 RNA methyltransferase Piwi PF02171.17 CCF50705.1 - 6.8e-78 262.0 0.0 1e-77 261.4 0.0 1.2 1 0 0 1 1 1 1 Piwi domain ArgoN PF16486.5 CCF50705.1 - 5.9e-14 52.9 0.0 1.2e-13 51.9 0.0 1.5 1 0 0 1 1 1 1 N-terminal domain of argonaute ArgoL1 PF08699.10 CCF50705.1 - 1.7e-12 46.8 0.0 5.3e-12 45.2 0.0 1.9 1 0 0 1 1 1 1 Argonaute linker 1 domain PAZ PF02170.22 CCF50705.1 - 8.2e-12 45.1 0.0 1.5e-11 44.3 0.0 1.3 1 0 0 1 1 1 1 PAZ domain ArgoL2 PF16488.5 CCF50705.1 - 6.4e-10 39.2 0.0 1.7e-09 37.9 0.0 1.8 1 0 0 1 1 1 1 Argonaute linker 2 domain ArgoMid PF16487.5 CCF50705.1 - 0.0034 17.6 0.0 0.0076 16.5 0.0 1.6 1 0 0 1 1 1 1 Mid domain of argonaute DUF2461 PF09365.10 CCF50706.1 - 3.1e-68 229.8 0.4 5.8e-68 229.0 0.4 1.4 1 0 0 1 1 1 1 Conserved hypothetical protein (DUF2461) Proteasome PF00227.26 CCF50707.1 - 1.8e-36 125.4 0.0 2.1e-36 125.2 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit SAMP PF05924.11 CCF50707.1 - 0.02 14.1 0.7 0.034 13.5 0.7 1.3 1 0 0 1 1 1 0 SAMP Motif Mis12 PF05859.12 CCF50708.1 - 2e-26 92.7 0.0 3.5e-26 91.8 0.0 1.4 1 0 0 1 1 1 1 Mis12 protein NDUFV3 PF15880.5 CCF50708.1 - 0.11 12.5 0.1 0.25 11.4 0.1 1.6 1 0 0 1 1 1 0 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial TMEM61 PF15105.6 CCF50708.1 - 9.5 6.0 9.5 1.7 8.4 1.3 2.8 3 0 0 3 3 3 0 TMEM61 protein family FA_hydroxylase PF04116.13 CCF50709.1 - 1.6e-19 70.6 9.5 1.6e-19 70.6 9.5 2.2 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily Acetyltransf_17 PF17668.1 CCF50709.1 - 0.081 13.7 0.4 0.2 12.5 0.0 1.8 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain DUF2607 PF10795.9 CCF50709.1 - 7.7 6.7 7.0 1.6 8.9 0.4 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF2607) PI3_PI4_kinase PF00454.27 CCF50710.1 - 1.2e-56 192.3 0.0 2.5e-56 191.3 0.0 1.6 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase TAN PF11640.8 CCF50710.1 - 1.5e-40 138.8 1.1 4.6e-40 137.2 0.7 2.2 2 0 0 2 2 2 1 Telomere-length maintenance and DNA damage repair FATC PF02260.20 CCF50710.1 - 4.3e-08 32.8 0.0 1.3e-07 31.3 0.0 1.9 1 0 0 1 1 1 1 FATC domain Phage_min_cap2 PF06152.11 CCF50710.1 - 1 8.2 5.3 12 4.7 0.0 2.4 2 0 0 2 2 2 0 Phage minor capsid protein 2 PDH PF02153.17 CCF50711.1 - 4.9e-16 58.5 0.0 7.2e-16 58.0 0.0 1.2 1 0 0 1 1 1 1 Prephenate dehydrogenase F420_oxidored PF03807.17 CCF50711.1 - 1.2e-05 25.8 0.0 4.3e-05 24.0 0.0 2.0 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_2 PF03446.15 CCF50711.1 - 1.6e-05 25.1 0.0 3.5e-05 24.0 0.0 1.5 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Shikimate_DH PF01488.20 CCF50711.1 - 6.3e-05 23.0 0.0 0.00013 22.1 0.0 1.5 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase ApbA PF02558.16 CCF50711.1 - 0.0043 16.7 0.0 0.013 15.1 0.0 1.9 1 1 0 1 1 1 1 Ketopantoate reductase PanE/ApbA IlvN PF07991.12 CCF50711.1 - 0.011 15.4 0.0 0.017 14.7 0.0 1.3 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain 2-Hacid_dh_C PF02826.19 CCF50711.1 - 0.041 13.2 0.0 0.078 12.3 0.0 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain TrkA_N PF02254.18 CCF50711.1 - 0.098 12.9 0.0 0.21 11.9 0.0 1.5 1 0 0 1 1 1 0 TrkA-N domain SNRNP27 PF08648.12 CCF50712.1 - 7.1e-30 102.9 0.5 1.2e-29 102.2 0.5 1.3 1 0 0 1 1 1 1 U4/U6.U5 small nuclear ribonucleoproteins NDUF_B4 PF07225.12 CCF50713.1 - 0.00019 21.3 0.0 0.00022 21.1 0.0 1.1 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B15 subunit (NDUFB4) PX PF00787.24 CCF50714.1 - 1.5e-06 28.2 0.0 3.3e-06 27.1 0.0 1.5 1 0 0 1 1 1 1 PX domain Melibiase_2 PF16499.5 CCF50715.1 - 5.7e-18 65.1 0.1 6.7e-18 64.9 0.1 1.0 1 0 0 1 1 1 1 Alpha galactosidase A Melibiase PF02065.18 CCF50715.1 - 0.036 13.0 0.0 0.058 12.3 0.0 1.3 1 1 0 1 1 1 0 Melibiase Melibiase_2 PF16499.5 CCF50716.1 - 1.1e-12 47.8 0.2 1.5e-12 47.3 0.2 1.2 1 0 0 1 1 1 1 Alpha galactosidase A Melibiase_C PF17801.1 CCF50716.1 - 8.7e-06 25.7 1.8 0.00043 20.3 1.8 2.4 1 1 0 1 1 1 1 Alpha galactosidase C-terminal beta sandwich domain Pico_P1A PF02226.16 CCF50716.1 - 0.031 14.3 0.0 0.14 12.3 0.0 1.9 2 0 0 2 2 2 0 Picornavirus coat protein (VP4) CFEM PF05730.11 CCF50717.1 - 9.6e-06 25.6 10.5 1.5e-05 25.0 10.5 1.3 1 0 0 1 1 1 1 CFEM domain Antimicrobial25 PF16839.5 CCF50717.1 - 0.12 12.5 10.4 0.12 12.4 8.9 1.9 1 1 0 1 1 1 0 Nematode antimicrobial peptide TIL PF01826.17 CCF50717.1 - 1 9.7 8.3 1.7 8.9 8.3 1.3 1 0 0 1 1 1 0 Trypsin Inhibitor like cysteine rich domain AA_permease PF00324.21 CCF50719.1 - 1.1e-117 393.7 40.2 1.3e-117 393.4 40.2 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 CCF50719.1 - 5.2e-36 124.4 41.3 6.2e-36 124.1 41.3 1.0 1 0 0 1 1 1 1 Amino acid permease DUF4781 PF16013.5 CCF50719.1 - 0.28 10.0 1.1 0.56 9.0 1.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4781) DUF1989 PF09347.10 CCF50720.1 - 8.4e-63 211.0 0.0 1.1e-62 210.6 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1989) HMA PF00403.26 CCF50723.1 - 4.2e-16 59.1 0.8 4.9e-16 58.9 0.8 1.1 1 0 0 1 1 1 1 Heavy-metal-associated domain UPF0004 PF00919.20 CCF50723.1 - 0.072 13.1 0.1 0.088 12.9 0.1 1.1 1 0 0 1 1 1 0 Uncharacterized protein family UPF0004 HA2 PF04408.23 CCF50724.1 - 2.7e-20 72.7 0.0 2.7e-20 72.7 0.0 3.6 6 0 0 6 6 4 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 CCF50724.1 - 5.5e-15 55.5 0.0 2.6e-14 53.4 0.0 2.1 2 0 0 2 2 2 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 CCF50724.1 - 2.9e-12 46.9 0.0 5.9e-12 45.9 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 CCF50724.1 - 6.1e-08 32.6 0.0 1.3e-07 31.6 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 CCF50724.1 - 1.4e-05 25.4 0.3 5.3e-05 23.5 0.3 2.0 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 CCF50724.1 - 0.00056 19.7 0.0 0.0013 18.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 CCF50724.1 - 0.0015 18.9 0.0 0.0031 17.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 CCF50724.1 - 0.0047 17.1 0.0 0.027 14.6 0.0 2.4 1 1 0 1 1 1 1 AAA domain T2SSE PF00437.20 CCF50724.1 - 0.011 14.8 0.1 0.032 13.3 0.0 1.7 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_7 PF12775.7 CCF50724.1 - 0.029 13.9 0.0 0.055 13.0 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region DUF2075 PF09848.9 CCF50724.1 - 0.041 13.1 0.0 0.073 12.3 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) ABC_tran PF00005.27 CCF50724.1 - 0.041 14.4 0.0 0.12 12.9 0.0 1.8 1 0 0 1 1 1 0 ABC transporter AAA_16 PF13191.6 CCF50724.1 - 0.053 13.9 0.0 0.22 11.9 0.0 2.1 1 0 0 1 1 1 0 AAA ATPase domain AAA_14 PF13173.6 CCF50724.1 - 0.054 13.5 0.1 0.44 10.6 0.1 2.3 1 1 0 1 1 1 0 AAA domain ATPase PF06745.13 CCF50724.1 - 0.061 12.7 0.0 0.12 11.7 0.0 1.4 1 0 0 1 1 1 0 KaiC PhoH PF02562.16 CCF50724.1 - 0.067 12.6 0.0 0.15 11.5 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein NACHT PF05729.12 CCF50724.1 - 0.079 12.9 0.1 0.7 9.8 0.0 2.3 2 0 0 2 2 2 0 NACHT domain p450 PF00067.22 CCF50725.1 - 7.4e-64 216.2 0.0 1.5e-56 192.1 0.0 2.5 2 1 0 2 2 2 2 Cytochrome P450 Perilipin PF03036.16 CCF50727.1 - 2e-11 43.6 0.7 4.2e-07 29.3 0.0 2.2 1 1 1 2 2 2 2 Perilipin family Gp-FAR-1 PF05823.12 CCF50727.1 - 0.015 15.7 1.4 0.027 14.8 1.4 1.4 1 0 0 1 1 1 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) I_LWEQ PF01608.17 CCF50727.1 - 0.022 15.0 0.3 0.046 14.0 0.3 1.7 1 0 0 1 1 1 0 I/LWEQ domain LIF_OSM PF01291.17 CCF50727.1 - 0.028 14.6 0.1 0.066 13.3 0.1 1.8 1 1 0 1 1 1 0 LIF / OSM family ApoLp-III PF07464.11 CCF50727.1 - 0.028 14.5 2.6 0.081 13.0 2.0 2.0 1 1 1 2 2 2 0 Apolipophorin-III precursor (apoLp-III) HMG_CoA_synt_C PF08540.10 CCF50727.1 - 0.045 13.4 0.4 0.086 12.4 0.3 1.4 1 1 0 1 1 1 0 Hydroxymethylglutaryl-coenzyme A synthase C terminal Apolipoprotein PF01442.18 CCF50727.1 - 0.058 13.3 2.1 0.28 11.0 1.0 2.1 1 1 1 2 2 2 0 Apolipoprotein A1/A4/E domain TBCA PF02970.16 CCF50727.1 - 0.066 13.6 0.2 0.18 12.2 0.1 1.8 2 0 0 2 2 2 0 Tubulin binding cofactor A AAA PF00004.29 CCF50729.1 - 2.1e-56 190.0 0.0 3e-43 147.4 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) PEX-1N PF09262.11 CCF50729.1 - 1.1e-25 89.8 0.1 2.4e-25 88.8 0.1 1.6 1 0 0 1 1 1 1 Peroxisome biogenesis factor 1, N-terminal AAA_lid_3 PF17862.1 CCF50729.1 - 1.1e-13 50.7 1.8 6.5e-10 38.7 0.1 2.9 2 0 0 2 2 2 2 AAA+ lid domain AAA_16 PF13191.6 CCF50729.1 - 1e-11 45.5 1.2 0.00035 21.0 0.0 4.4 2 1 1 3 3 3 2 AAA ATPase domain RuvB_N PF05496.12 CCF50729.1 - 4.2e-07 29.8 0.0 0.0033 17.2 0.0 3.1 3 0 0 3 3 3 2 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 CCF50729.1 - 6.3e-07 30.0 0.0 0.043 14.4 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 CCF50729.1 - 2.3e-06 28.0 2.3 0.71 10.1 0.1 4.7 3 2 1 4 4 4 2 AAA domain AAA_25 PF13481.6 CCF50729.1 - 2.3e-06 27.3 3.9 0.27 10.8 0.0 4.2 2 2 1 4 4 4 2 AAA domain AAA_5 PF07728.14 CCF50729.1 - 5.4e-06 26.5 0.0 0.074 13.0 0.0 3.0 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) TsaE PF02367.17 CCF50729.1 - 6.6e-06 26.1 0.0 0.21 11.6 0.0 2.9 3 0 0 3 3 3 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_33 PF13671.6 CCF50729.1 - 2.4e-05 24.5 0.0 0.048 13.8 0.0 3.3 3 0 0 3 3 3 1 AAA domain RNA_helicase PF00910.22 CCF50729.1 - 3.3e-05 24.2 0.0 0.36 11.2 0.0 2.5 2 0 0 2 2 2 2 RNA helicase Mg_chelatase PF01078.21 CCF50729.1 - 4e-05 23.1 0.2 0.16 11.3 0.0 2.5 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_17 PF13207.6 CCF50729.1 - 5.5e-05 23.6 0.1 0.37 11.2 0.0 3.1 2 0 0 2 2 2 2 AAA domain Viral_helicase1 PF01443.18 CCF50729.1 - 6.7e-05 22.7 0.0 0.32 10.7 0.0 2.4 2 0 0 2 2 2 2 Viral (Superfamily 1) RNA helicase AAA_28 PF13521.6 CCF50729.1 - 8.7e-05 22.8 0.2 0.1 12.8 0.3 2.9 2 0 0 2 2 2 1 AAA domain TIP49 PF06068.13 CCF50729.1 - 0.00013 21.4 0.0 0.12 11.6 0.0 2.3 2 0 0 2 2 2 2 TIP49 P-loop domain NACHT PF05729.12 CCF50729.1 - 0.00015 21.7 1.5 0.26 11.2 0.1 3.7 3 1 0 3 3 3 1 NACHT domain AAA_14 PF13173.6 CCF50729.1 - 0.00036 20.6 0.0 1.2 9.2 0.0 2.6 2 0 0 2 2 2 2 AAA domain Zeta_toxin PF06414.12 CCF50729.1 - 0.00037 19.8 0.2 0.38 10.0 0.1 2.5 2 0 0 2 2 2 2 Zeta toxin AAA_24 PF13479.6 CCF50729.1 - 0.0005 19.8 0.0 0.24 11.1 0.0 2.8 3 0 0 3 3 3 1 AAA domain DUF2075 PF09848.9 CCF50729.1 - 0.00069 19.0 0.3 3 7.0 0.0 3.2 3 0 0 3 3 3 1 Uncharacterized conserved protein (DUF2075) AAA_3 PF07726.11 CCF50729.1 - 0.002 18.0 0.0 1.8 8.5 0.0 2.6 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.6 CCF50729.1 - 0.0021 18.4 0.0 0.052 13.9 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_2 PF07724.14 CCF50729.1 - 0.0024 18.0 0.0 0.052 13.7 0.0 2.5 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) Rad17 PF03215.15 CCF50729.1 - 0.0025 17.8 0.0 0.87 9.5 0.0 2.5 2 0 0 2 2 2 1 Rad17 P-loop domain SKI PF01202.22 CCF50729.1 - 0.0068 16.5 0.1 5.1 7.2 0.0 3.1 3 0 0 3 3 3 0 Shikimate kinase AAA_7 PF12775.7 CCF50729.1 - 0.0075 15.8 0.0 1 8.9 0.1 2.5 2 0 0 2 2 2 1 P-loop containing dynein motor region Sigma54_activ_2 PF14532.6 CCF50729.1 - 0.011 15.9 0.0 1.5 9.0 0.0 2.6 2 0 0 2 2 2 0 Sigma-54 interaction domain IstB_IS21 PF01695.17 CCF50729.1 - 0.011 15.5 0.0 1.8 8.3 0.0 2.5 2 0 0 2 2 2 0 IstB-like ATP binding protein NTPase_1 PF03266.15 CCF50729.1 - 0.016 15.1 0.1 0.57 10.1 0.0 2.5 2 0 0 2 2 2 0 NTPase ATPase PF06745.13 CCF50729.1 - 0.023 14.0 0.1 6.6 6.0 0.1 2.5 2 0 0 2 2 2 0 KaiC Cytidylate_kin2 PF13189.6 CCF50729.1 - 0.036 14.2 0.0 0.92 9.6 0.0 2.8 2 0 0 2 2 2 0 Cytidylate kinase-like family NB-ARC PF00931.22 CCF50729.1 - 0.037 13.2 0.0 3.9 6.6 0.0 2.4 2 0 0 2 2 2 0 NB-ARC domain KTI12 PF08433.10 CCF50729.1 - 0.076 12.4 1.8 0.73 9.2 0.1 3.1 3 1 1 4 4 4 0 Chromatin associated protein KTI12 ABC_tran PF00005.27 CCF50729.1 - 0.68 10.4 3.3 49 4.4 0.5 3.3 3 1 0 4 4 3 0 ABC transporter eRF1_2 PF03464.15 CCF50730.1 - 6.4e-46 156.0 0.1 1.4e-45 154.8 0.0 1.7 2 0 0 2 2 2 1 eRF1 domain 2 eRF1_3 PF03465.15 CCF50730.1 - 1.7e-37 128.3 0.1 3.1e-37 127.5 0.1 1.4 1 0 0 1 1 1 1 eRF1 domain 3 eRF1_1 PF03463.15 CCF50730.1 - 9.7e-19 67.6 0.0 1.6e-18 67.0 0.0 1.3 1 0 0 1 1 1 1 eRF1 domain 1 acVLRF1 PF18859.1 CCF50730.1 - 6.6e-08 32.9 0.0 1.2e-07 32.1 0.0 1.4 1 0 0 1 1 1 1 Actinobacteria/chloroflexi VLRF1 release factor baeRF_family10 PF18854.1 CCF50730.1 - 4.7e-06 26.9 0.1 1.1e-05 25.7 0.0 1.7 2 0 0 2 2 2 1 Bacterial archaeo-eukaryotic release factor family 10 DUF3440 PF11922.8 CCF50730.1 - 0.017 14.8 0.0 0.036 13.7 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3440) DUF4202 PF13875.6 CCF50731.1 - 1.2e-63 214.4 0.1 2.5e-63 213.4 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4202) Methyltransf_23 PF13489.6 CCF50731.1 - 5.9e-17 62.0 0.0 1.3e-16 60.9 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF50731.1 - 2.4e-13 50.6 0.0 5.8e-13 49.4 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF50731.1 - 1.5e-12 48.1 0.0 7.3e-12 45.9 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF50731.1 - 1.5e-10 41.6 0.0 4.3e-10 40.1 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF50731.1 - 3.1e-07 30.3 0.0 1.6e-06 28.0 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain NNMT_PNMT_TEMT PF01234.17 CCF50731.1 - 0.00019 20.7 0.0 0.53 9.4 0.0 2.3 2 0 0 2 2 2 2 NNMT/PNMT/TEMT family Methyltransf_24 PF13578.6 CCF50731.1 - 0.00082 20.4 0.0 0.0024 18.9 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CCF50731.1 - 0.003 17.1 0.0 0.0064 16.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase small domain DUF1754 PF08555.10 CCF50732.1 - 4.8e-17 62.6 16.8 7.3e-17 62.0 16.8 1.3 1 0 0 1 1 1 1 Eukaryotic family of unknown function (DUF1754) Asp-B-Hydro_N PF05279.11 CCF50732.1 - 0.099 12.7 9.8 0.12 12.4 9.8 1.0 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region SpoIIIAH PF12685.7 CCF50732.1 - 0.7 9.7 12.0 0.81 9.5 12.0 1.1 1 0 0 1 1 1 0 SpoIIIAH-like protein LAP1C PF05609.12 CCF50732.1 - 0.88 8.6 11.4 1 8.4 11.4 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) PI3K_1B_p101 PF10486.9 CCF50732.1 - 1.8 6.3 10.0 2 6.1 10.0 1.0 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit RR_TM4-6 PF06459.12 CCF50732.1 - 4.3 7.1 14.2 5.3 6.8 14.2 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 SLC12 PF03522.15 CCF50732.1 - 4.7 6.1 8.7 5.7 5.9 8.7 1.0 1 0 0 1 1 1 0 Solute carrier family 12 GREB1 PF15782.5 CCF50732.1 - 6.6 3.7 8.6 6.9 3.7 8.6 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Presenilin PF01080.17 CCF50732.1 - 7.2 5.3 11.0 7.9 5.1 11.0 1.1 1 0 0 1 1 1 0 Presenilin OST3_OST6 PF04756.13 CCF50733.1 - 3.4e-91 305.6 0.3 4.9e-91 305.1 0.3 1.2 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin PF00085.20 CCF50733.1 - 0.00098 19.1 0.0 0.0019 18.1 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin UPF0014 PF03649.13 CCF50733.1 - 0.017 14.5 1.3 0.48 9.7 0.1 2.2 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0014) HlyIII PF03006.20 CCF50733.1 - 0.03 14.0 1.8 0.84 9.3 0.6 2.4 2 0 0 2 2 2 0 Haemolysin-III related DUF3112 PF11309.8 CCF50733.1 - 0.13 11.7 1.6 0.19 11.2 0.5 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3112) VIT1 PF01988.19 CCF50733.1 - 9.4 6.0 6.6 99 2.7 6.6 2.3 1 1 0 1 1 1 0 VIT family Transp_cyt_pur PF02133.15 CCF50734.1 - 5e-32 111.2 28.4 7.2e-32 110.7 28.4 1.2 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Dynamitin PF04912.14 CCF50735.1 - 1.8e-84 284.3 10.1 2.4e-84 283.9 10.1 1.2 1 0 0 1 1 1 1 Dynamitin DUF1664 PF07889.12 CCF50735.1 - 0.01 15.9 0.9 0.029 14.4 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Apolipoprotein PF01442.18 CCF50735.1 - 0.016 15.1 5.6 0.016 15.1 5.6 3.1 3 1 0 3 3 3 0 Apolipoprotein A1/A4/E domain Fib_alpha PF08702.10 CCF50735.1 - 0.033 14.4 0.6 0.26 11.5 0.0 2.5 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family DUF3584 PF12128.8 CCF50735.1 - 0.25 8.8 8.9 0.017 12.7 1.8 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) Syntaxin_2 PF14523.6 CCF50735.1 - 0.56 10.6 4.5 0.49 10.8 0.3 2.7 3 0 0 3 3 3 0 Syntaxin-like protein KxDL PF10241.9 CCF50735.1 - 1.3 9.3 4.5 0.5 10.7 0.5 2.4 3 0 0 3 3 3 0 Uncharacterized conserved protein FliT PF05400.13 CCF50735.1 - 2.1 9.2 14.3 0.48 11.3 5.5 3.1 2 1 0 2 2 2 0 Flagellar protein FliT Snapin_Pallidin PF14712.6 CCF50735.1 - 2.4 8.6 6.4 0.74 10.3 0.3 2.9 3 0 0 3 3 3 0 Snapin/Pallidin XhlA PF10779.9 CCF50735.1 - 2.4 8.4 6.9 15 5.9 1.0 3.5 3 1 1 4 4 4 0 Haemolysin XhlA Jnk-SapK_ap_N PF09744.9 CCF50735.1 - 3.5 7.8 13.7 0.74 10.0 6.1 2.7 2 1 0 2 2 2 0 JNK_SAPK-associated protein-1 CLZ PF16526.5 CCF50735.1 - 8.4 6.8 15.8 3.3 8.1 6.6 3.4 3 0 0 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels ADK PF00406.22 CCF50736.1 - 3.8e-44 150.4 0.2 2e-23 83.2 0.0 2.1 2 0 0 2 2 2 2 Adenylate kinase AAA_17 PF13207.6 CCF50736.1 - 1e-33 116.6 0.1 8e-32 110.5 0.1 2.2 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 CCF50736.1 - 1.4e-08 35.4 0.0 2.1e-08 34.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain Thymidylate_kin PF02223.17 CCF50736.1 - 0.00024 20.8 0.0 0.55 9.9 0.0 2.1 2 0 0 2 2 2 2 Thymidylate kinase AAA_33 PF13671.6 CCF50736.1 - 0.00037 20.7 0.0 0.0029 17.8 0.0 2.1 1 1 0 1 1 1 1 AAA domain Cytidylate_kin PF02224.18 CCF50736.1 - 0.047 13.4 0.4 7.4 6.2 0.0 2.1 2 0 0 2 2 2 0 Cytidylate kinase BCS1_N PF08740.11 CCF50737.1 - 8.7e-57 192.1 0.0 1.4e-56 191.5 0.0 1.3 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.29 CCF50737.1 - 5.6e-17 62.4 0.0 9.8e-17 61.6 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 CCF50737.1 - 0.0016 18.9 0.5 0.024 15.0 0.2 2.9 1 1 1 2 2 2 1 AAA ATPase domain DUF815 PF05673.13 CCF50737.1 - 0.0068 15.6 0.0 0.012 14.8 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_25 PF13481.6 CCF50737.1 - 0.0076 15.8 0.1 0.12 11.9 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 CCF50737.1 - 0.023 14.9 0.0 0.051 13.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 CCF50737.1 - 0.034 13.9 0.0 0.074 12.8 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Viral_helicase1 PF01443.18 CCF50737.1 - 0.095 12.4 0.0 0.15 11.8 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase zn-ribbon_14 PF16503.5 CCF50738.1 - 2.2e-16 59.1 3.6 2.2e-16 59.1 3.6 3.4 3 0 0 3 3 3 1 Zinc-ribbon ATP_bind_3 PF01171.20 CCF50738.1 - 3.4e-15 56.3 0.0 7.9e-15 55.1 0.0 1.7 1 0 0 1 1 1 1 PP-loop family CTU2 PF10288.9 CCF50738.1 - 0.047 13.9 2.3 0.12 12.7 0.3 2.4 3 0 0 3 3 3 0 Cytoplasmic tRNA 2-thiolation protein 2 HIPIP PF01355.17 CCF50738.1 - 0.21 12.0 5.6 4.7 7.6 0.1 3.3 3 1 0 3 3 3 0 High potential iron-sulfur protein DUF2616 PF11077.8 CCF50738.1 - 3.1 7.5 6.2 3 7.5 0.8 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF2616) ICMT PF04140.14 CCF50739.1 - 0.0055 17.1 0.0 0.47 10.9 0.0 2.2 1 1 0 1 1 1 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.13 CCF50739.1 - 0.013 15.9 0.1 0.045 14.2 0.0 1.7 2 0 0 2 2 2 0 Phospholipid methyltransferase WD40 PF00400.32 CCF50740.1 - 4e-39 131.9 20.6 5e-06 27.2 0.1 8.4 7 1 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF50740.1 - 5.9e-12 45.7 2.3 0.049 13.9 0.0 6.8 2 1 5 7 7 7 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 CCF50740.1 - 0.00025 19.8 5.2 0.47 9.0 0.1 4.3 2 2 1 4 4 4 2 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 CCF50740.1 - 0.026 13.5 0.2 0.65 8.9 0.0 2.5 1 1 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein PDZ_assoc PF10600.9 CCF50740.1 - 0.19 12.6 3.0 0.67 10.8 3.0 2.0 1 0 0 1 1 1 0 PDZ-associated domain of NMDA receptors UCH PF00443.29 CCF50741.1 - 1e-70 238.2 0.0 1.4e-70 237.7 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase DUSP PF06337.12 CCF50741.1 - 3.9e-19 69.0 0.0 1.3e-18 67.4 0.0 1.9 2 0 0 2 2 2 1 DUSP domain UCH_1 PF13423.6 CCF50741.1 - 2.9e-12 46.8 0.0 1.9e-05 24.4 0.0 3.2 3 0 0 3 3 3 3 Ubiquitin carboxyl-terminal hydrolase USP7_C2 PF14533.6 CCF50741.1 - 0.0012 18.6 0.0 0.0023 17.7 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-specific protease C-terminal Velvet PF11754.8 CCF50744.1 - 2.1e-55 188.4 11.8 9.9e-38 130.5 0.0 3.1 2 1 1 3 3 3 2 Velvet factor G_path_suppress PF15991.5 CCF50744.1 - 1.9 8.5 9.3 2.5 8.1 8.8 1.5 1 1 0 1 1 1 0 G-protein pathway suppressor Velvet PF11754.8 CCF50745.1 - 2.7e-35 122.5 0.1 3.4e-35 122.2 0.1 1.0 1 0 0 1 1 1 1 Velvet factor SPX PF03105.19 CCF50745.1 - 0.14 12.1 1.1 0.17 11.8 1.1 1.1 1 0 0 1 1 1 0 SPX domain RSB_motif PF16294.5 CCF50745.1 - 0.2 12.0 0.0 0.35 11.1 0.0 1.4 1 0 0 1 1 1 0 RNSP1-SAP18 binding (RSB) motif 4HBT PF03061.22 CCF50748.1 - 2.1e-11 44.0 0.0 3.8e-11 43.2 0.0 1.5 1 0 0 1 1 1 1 Thioesterase superfamily DUF4442 PF14539.6 CCF50748.1 - 0.025 14.7 0.0 0.035 14.2 0.0 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4442) 4HBT_3 PF13622.6 CCF50748.1 - 0.12 12.5 0.0 0.15 12.3 0.0 1.1 1 0 0 1 1 1 0 Thioesterase-like superfamily Zn_clus PF00172.18 CCF50750.1 - 4.4e-07 29.9 11.2 1e-06 28.8 11.2 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 CCF50750.1 - 4.7e-06 25.8 0.1 1.1e-05 24.6 0.1 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain TRM PF02005.16 CCF50751.1 - 3.2e-116 388.6 0.0 1e-88 298.1 0.0 2.1 2 0 0 2 2 2 2 N2,N2-dimethylguanosine tRNA methyltransferase DUF4230 PF14014.6 CCF50751.1 - 0.093 13.0 6.9 0.59 10.4 5.9 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4230) Med15 PF09606.10 CCF50751.1 - 0.13 11.0 15.6 0.21 10.2 15.6 1.2 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal GREB1 PF15782.5 CCF50751.1 - 0.42 7.7 6.9 0.57 7.2 6.9 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DDHD PF02862.17 CCF50751.1 - 0.55 10.4 3.4 0.21 11.7 0.4 1.8 2 0 0 2 2 2 0 DDHD domain Presenilin PF01080.17 CCF50751.1 - 0.6 8.8 11.6 1.2 7.8 11.6 1.4 1 0 0 1 1 1 0 Presenilin SAPS PF04499.15 CCF50751.1 - 0.78 8.5 4.7 1.2 7.9 4.7 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Spt20 PF12090.8 CCF50751.1 - 0.94 9.0 16.4 1.7 8.2 16.4 1.4 1 0 0 1 1 1 0 Spt20 family Hid1 PF12722.7 CCF50751.1 - 3.7 5.5 10.2 5.3 5.0 10.2 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein zinc_ribbon_15 PF17032.5 CCF50752.1 - 9.8e-06 26.2 0.3 9.8e-06 26.2 0.3 1.7 2 0 0 2 2 2 1 zinc-ribbon family zf-NADH-PPase PF09297.11 CCF50752.1 - 0.0039 16.8 1.6 0.0039 16.8 1.6 1.9 2 0 0 2 2 2 1 NADH pyrophosphatase zinc ribbon domain Zn_Tnp_IS1595 PF12760.7 CCF50752.1 - 0.2 11.7 3.8 0.73 9.9 3.8 1.9 1 1 0 1 1 1 0 Transposase zinc-ribbon domain FYVE_2 PF02318.16 CCF50752.1 - 0.79 9.9 3.6 2.7 8.2 0.4 2.0 1 1 1 2 2 2 0 FYVE-type zinc finger NIF PF03031.18 CCF50754.1 - 4.2e-23 81.8 0.0 6.5e-23 81.2 0.0 1.3 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase ubiquitin PF00240.23 CCF50754.1 - 0.0085 15.8 0.0 0.015 15.0 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family Cyclin PF08613.11 CCF50755.1 - 3.7e-07 30.7 0.0 3.7e-07 30.7 0.0 2.7 3 0 0 3 3 3 1 Cyclin Tmemb_cc2 PF10267.9 CCF50756.1 - 0.81 8.8 2.2 1.3 8.1 2.2 1.2 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein DUF456 PF04306.13 CCF50756.1 - 1.9 8.7 10.1 0.28 11.5 2.6 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF456) Bax1-I PF01027.20 CCF50756.1 - 2.9 7.7 8.6 5.1 6.9 8.6 1.4 1 0 0 1 1 1 0 Inhibitor of apoptosis-promoting Bax1 DUF4536 PF15055.6 CCF50756.1 - 3.4 8.0 6.1 17 5.8 0.2 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4536) Gly-zipper_Omp PF13488.6 CCF50756.1 - 5.4 7.1 40.1 2.9 8.0 7.5 4.6 4 0 0 4 4 4 0 Glycine zipper Amino_oxidase PF01593.24 CCF50757.1 - 4.1e-20 72.5 0.0 2.6e-17 63.3 0.0 2.2 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 CCF50757.1 - 1.5e-13 50.8 0.2 5.7e-13 48.9 0.1 2.1 2 0 0 2 2 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CCF50757.1 - 1.3e-10 41.1 0.2 2.4e-07 30.3 0.0 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CCF50757.1 - 2e-10 40.8 0.1 7.5e-10 38.9 0.1 1.9 1 1 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 CCF50757.1 - 2.3e-05 23.7 1.9 4.4e-05 22.7 1.4 1.7 2 0 0 2 2 2 1 FAD binding domain HI0933_like PF03486.14 CCF50757.1 - 9.9e-05 21.2 0.3 0.00039 19.2 0.2 1.8 2 0 0 2 2 2 1 HI0933-like protein MCRA PF06100.11 CCF50757.1 - 0.00025 20.0 0.0 0.53 9.0 0.0 2.1 2 0 0 2 2 2 2 MCRA family FAD_oxidored PF12831.7 CCF50757.1 - 0.00029 20.3 0.0 0.00053 19.5 0.0 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase ApbA PF02558.16 CCF50757.1 - 0.0024 17.6 0.4 0.0043 16.7 0.4 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA Pyr_redox_3 PF13738.6 CCF50757.1 - 0.0031 16.8 0.0 0.0053 16.1 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 CCF50757.1 - 0.0031 16.8 0.3 0.0064 15.8 0.3 1.5 1 0 0 1 1 1 1 FAD binding domain Pyr_redox PF00070.27 CCF50757.1 - 0.0039 17.7 2.6 0.073 13.6 0.3 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_Gly3P_dh_N PF01210.23 CCF50757.1 - 0.004 17.2 0.1 0.0091 16.0 0.1 1.6 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Rossmann-like PF10727.9 CCF50757.1 - 0.007 16.2 0.1 0.016 15.1 0.1 1.5 1 0 0 1 1 1 1 Rossmann-like domain GIDA PF01134.22 CCF50757.1 - 0.013 14.6 2.0 0.033 13.3 0.9 2.0 2 0 0 2 2 2 0 Glucose inhibited division protein A Thi4 PF01946.17 CCF50757.1 - 0.028 13.7 0.0 0.071 12.3 0.0 1.6 1 0 0 1 1 1 0 Thi4 family NAD_binding_9 PF13454.6 CCF50757.1 - 0.032 14.2 2.9 0.05 13.6 0.3 2.4 2 0 0 2 2 2 0 FAD-NAD(P)-binding F420_oxidored PF03807.17 CCF50757.1 - 0.034 14.7 0.5 0.11 13.1 0.5 1.9 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent GMC_oxred_N PF00732.19 CCF50757.1 - 0.045 13.1 0.4 6.2 6.1 0.0 2.3 2 0 0 2 2 2 0 GMC oxidoreductase Lycopene_cycl PF05834.12 CCF50757.1 - 0.05 12.7 0.2 0.05 12.7 0.2 1.9 2 0 0 2 2 2 0 Lycopene cyclase protein TrkA_N PF02254.18 CCF50757.1 - 0.054 13.7 0.1 0.13 12.5 0.1 1.6 1 0 0 1 1 1 0 TrkA-N domain Glyco_transf_4 PF13439.6 CCF50757.1 - 0.055 13.5 0.2 0.26 11.3 0.0 2.1 2 0 0 2 2 2 0 Glycosyltransferase Family 4 3HCDH_N PF02737.18 CCF50757.1 - 0.073 12.9 0.3 0.17 11.8 0.3 1.6 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain GDI PF00996.18 CCF50757.1 - 0.074 11.6 0.0 2.8 6.4 0.0 2.2 2 0 0 2 2 2 0 GDP dissociation inhibitor Glyco_trans_4_4 PF13579.6 CCF50757.1 - 0.088 13.3 1.0 3.6 8.0 0.1 2.5 2 0 0 2 2 2 0 Glycosyl transferase 4-like domain NAD_binding_7 PF13241.6 CCF50757.1 - 0.11 12.9 0.7 0.4 11.2 0.0 2.2 3 0 0 3 3 2 0 Putative NAD(P)-binding Trp_halogenase PF04820.14 CCF50757.1 - 0.26 10.1 4.2 2.9 6.6 0.4 2.3 2 0 0 2 2 2 0 Tryptophan halogenase Elongin_A PF06881.11 CCF50758.1 - 5.9e-31 107.1 2.8 9e-31 106.5 2.8 1.3 1 0 0 1 1 1 1 RNA polymerase II transcription factor SIII (Elongin) subunit A RabGAP-TBC PF00566.18 CCF50759.1 - 6.7e-44 150.1 0.0 1.2e-43 149.3 0.0 1.5 1 1 0 1 1 1 1 Rab-GTPase-TBC domain BRD4_CDT PF17105.5 CCF50759.1 - 1.6 8.4 6.5 1.8 8.3 0.9 2.4 2 0 0 2 2 2 0 C-terminal domain of bromodomain protein 4 Glutaredoxin PF00462.24 CCF50760.1 - 1e-17 64.1 0.0 3.1e-17 62.5 0.0 1.8 2 0 0 2 2 2 1 Glutaredoxin Thioredoxin PF00085.20 CCF50760.1 - 6.9e-13 48.5 0.0 1.6e-12 47.3 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 CCF50760.1 - 0.01 16.1 0.0 0.31 11.4 0.0 2.6 2 1 1 3 3 3 0 Thioredoxin-like HyaE PF07449.11 CCF50760.1 - 0.012 15.6 0.0 0.2 11.7 0.0 2.6 3 0 0 3 3 3 0 Hydrogenase-1 expression protein HyaE Thioredoxin_2 PF13098.6 CCF50760.1 - 0.013 15.9 0.0 0.78 10.2 0.0 2.9 2 1 0 2 2 2 0 Thioredoxin-like domain Thioredoxin_3 PF13192.6 CCF50760.1 - 0.021 14.9 0.5 0.26 11.4 0.0 2.7 3 1 0 3 3 3 0 Thioredoxin domain SH3BGR PF04908.15 CCF50760.1 - 0.058 13.6 0.0 0.16 12.2 0.0 1.7 1 0 0 1 1 1 0 SH3-binding, glutamic acid-rich protein DIM1 PF02966.16 CCF50760.1 - 0.17 11.7 0.0 0.36 10.6 0.0 1.5 2 0 0 2 2 2 0 Mitosis protein DIM1 Methyltransf_16 PF10294.9 CCF50761.1 - 7.7e-20 71.3 0.1 5.3e-12 45.8 0.0 2.1 2 0 0 2 2 2 2 Lysine methyltransferase Methyltransf_23 PF13489.6 CCF50761.1 - 1.3e-05 25.1 0.0 2.1e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF50761.1 - 0.006 17.3 0.0 0.072 13.8 0.0 2.3 1 1 1 2 2 2 1 Methyltransferase domain DREV PF05219.12 CCF50761.1 - 0.033 13.3 0.0 0.047 12.8 0.0 1.1 1 0 0 1 1 1 0 DREV methyltransferase Methyltransf_11 PF08241.12 CCF50761.1 - 0.034 14.8 0.0 0.24 12.1 0.0 2.4 2 1 0 2 2 2 0 Methyltransferase domain PrmA PF06325.13 CCF50761.1 - 0.057 12.8 0.0 0.089 12.2 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_31 PF13847.6 CCF50761.1 - 0.1 12.4 0.0 2.9 7.7 0.0 2.4 2 1 0 2 2 2 0 Methyltransferase domain Nuf2 PF03800.14 CCF50762.1 - 3.6e-36 124.4 0.0 3.6e-36 124.4 0.0 2.9 2 1 0 3 3 3 1 Nuf2 family GM_CSF PF01109.17 CCF50762.1 - 0.0005 20.2 1.4 0.0005 20.2 1.4 2.4 2 1 0 3 3 3 1 Granulocyte-macrophage colony-stimulating factor DHR10 PF18595.1 CCF50762.1 - 0.0005 20.1 18.3 0.0005 20.1 18.3 4.1 2 2 2 4 4 4 1 Designed helical repeat protein 10 domain APC_u5 PF16630.5 CCF50762.1 - 0.03 15.3 2.0 0.1 13.6 2.0 1.9 1 0 0 1 1 1 0 Unstructured region on APC between 1st and 2nd catenin-bdg motifs Arteri_nsp7a PF16749.5 CCF50762.1 - 0.04 14.1 5.7 1.5 9.0 0.3 2.7 2 0 0 2 2 2 0 Arterivirus nonstructural protein 7 alpha ATP-synt_G PF04718.15 CCF50762.1 - 0.17 12.8 0.2 0.17 12.8 0.2 3.8 3 2 2 5 5 5 0 Mitochondrial ATP synthase g subunit THOC7 PF05615.13 CCF50762.1 - 0.4 10.9 44.2 0.022 15.0 7.0 3.7 2 1 2 4 4 4 0 Tho complex subunit 7 Rab5-bind PF09311.11 CCF50762.1 - 0.56 9.5 44.7 0.087 12.2 38.0 2.0 1 1 1 2 2 2 0 Rabaptin-like protein Adhesin_P1_N PF18652.1 CCF50762.1 - 0.6 10.2 0.0 0.6 10.2 0.0 3.6 4 0 0 4 4 4 0 Adhesin P1 N-terminal domain LPD11 PF18824.1 CCF50762.1 - 2.7 8.2 8.2 7.9 6.6 4.3 3.1 2 1 0 2 2 2 0 Large polyvalent protein-associated domain 11 Baculo_PEP_C PF04513.12 CCF50762.1 - 5.4 7.1 19.5 1.6 8.8 1.9 4.1 1 1 3 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF3405 PF11885.8 CCF50763.1 - 7.6e-60 203.0 0.6 3.4e-38 131.6 0.1 2.6 1 1 1 2 2 2 2 Protein of unknown function (DUF3405) COG4 PF08318.12 CCF50764.1 - 8.7e-105 350.5 0.0 1.5e-104 349.7 0.0 1.4 1 0 0 1 1 1 1 COG4 transport protein ATG16 PF08614.11 CCF50764.1 - 0.048 13.9 0.9 0.1 12.8 0.9 1.5 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) RINT1_TIP1 PF04437.13 CCF50764.1 - 0.082 11.8 0.5 0.37 9.6 0.0 2.1 2 0 0 2 2 2 0 RINT-1 / TIP-1 family Cas_St_Csn2 PF16813.5 CCF50764.1 - 0.14 11.2 0.0 0.38 9.8 0.0 1.6 2 0 0 2 2 2 0 CRISPR-associated protein Csn2 subfamily St TIP49 PF06068.13 CCF50765.1 - 1.3e-159 531.1 0.3 1.7e-159 530.7 0.3 1.2 1 0 0 1 1 1 1 TIP49 P-loop domain TIP49_C PF17856.1 CCF50765.1 - 9.4e-24 83.3 2.2 5.4e-23 80.9 2.0 2.3 2 0 0 2 2 2 1 TIP49 AAA-lid domain AAA PF00004.29 CCF50765.1 - 1e-07 32.4 1.3 3.3e-05 24.3 0.0 3.0 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) DnaB_C PF03796.15 CCF50765.1 - 5.3e-07 29.2 0.8 5.3e-07 29.2 0.8 1.5 2 0 0 2 2 2 1 DnaB-like helicase C terminal domain RuvB_N PF05496.12 CCF50765.1 - 1.8e-06 27.8 0.9 0.0017 18.1 0.0 2.8 3 0 0 3 3 3 2 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 CCF50765.1 - 0.00027 21.4 0.8 0.00072 20.0 0.1 2.1 2 1 0 2 2 2 1 AAA ATPase domain AAA_19 PF13245.6 CCF50765.1 - 0.00091 19.6 3.4 0.0039 17.5 0.4 2.9 2 1 0 2 2 2 1 AAA domain Mg_chelatase PF01078.21 CCF50765.1 - 0.0018 17.7 1.4 0.046 13.1 0.2 2.5 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_22 PF13401.6 CCF50765.1 - 0.0021 18.4 0.2 0.77 10.0 0.0 2.6 1 1 0 2 2 2 1 AAA domain AAA_5 PF07728.14 CCF50765.1 - 0.0035 17.3 0.7 1.8 8.6 0.0 3.2 3 1 0 4 4 4 1 AAA domain (dynein-related subfamily) AAA_25 PF13481.6 CCF50765.1 - 0.011 15.3 1.3 0.02 14.4 0.1 1.9 2 1 0 2 2 2 0 AAA domain AAA_28 PF13521.6 CCF50765.1 - 0.013 15.8 0.1 0.044 14.0 0.0 2.0 1 1 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 CCF50765.1 - 0.029 14.1 0.1 6.5 6.4 0.0 2.6 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_11 PF13086.6 CCF50765.1 - 0.15 11.8 0.5 0.49 10.1 0.5 1.9 1 1 0 1 1 1 0 AAA domain Hydin_ADK PF17213.3 CCF50765.1 - 0.39 11.0 3.1 0.18 12.0 0.6 1.8 2 1 0 2 2 2 0 Hydin Adenylate kinase-like domain DUF1713 PF08213.11 CCF50766.1 - 1.9e-09 37.3 24.7 1.9e-09 37.3 24.7 2.0 2 0 0 2 2 2 1 Mitochondrial domain of unknown function (DUF1713) ImmE5 PF11480.8 CCF50766.1 - 0.093 13.2 0.0 0.24 11.9 0.0 1.6 1 0 0 1 1 1 0 Colicin-E5 Imm protein Syntaxin PF00804.25 CCF50767.1 - 2e-31 109.2 12.6 3.5e-31 108.5 12.6 1.4 1 0 0 1 1 1 1 Syntaxin SNARE PF05739.19 CCF50767.1 - 3.8e-10 39.6 1.4 1.1e-09 38.1 1.4 1.9 1 0 0 1 1 1 1 SNARE domain Syntaxin_2 PF14523.6 CCF50767.1 - 0.00024 21.4 18.8 0.00026 21.3 8.0 2.6 2 1 0 2 2 2 1 Syntaxin-like protein Prominin PF05478.11 CCF50767.1 - 0.0016 16.5 10.4 0.0033 15.5 0.3 2.0 2 0 0 2 2 2 2 Prominin DUF2207 PF09972.9 CCF50767.1 - 0.0062 15.4 1.1 0.018 13.9 0.0 1.8 1 1 0 2 2 2 1 Predicted membrane protein (DUF2207) Allexi_40kDa PF05549.11 CCF50767.1 - 0.053 13.0 8.0 0.041 13.4 2.0 2.1 2 0 0 2 2 2 0 Allexivirus 40kDa protein MCPsignal PF00015.21 CCF50767.1 - 0.068 13.0 8.7 0.12 12.2 1.7 2.7 2 0 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain PBP1_TM PF14812.6 CCF50767.1 - 0.096 13.1 2.0 0.16 12.3 0.1 2.2 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal SKA1 PF07160.12 CCF50767.1 - 0.26 11.1 15.1 0.15 11.9 2.1 2.8 1 1 0 2 2 2 0 Spindle and kinetochore-associated protein 1 Synaptobrevin PF00957.21 CCF50767.1 - 0.34 10.7 11.9 0.092 12.5 3.5 2.8 2 1 0 2 2 2 0 Synaptobrevin ISG65-75 PF11727.8 CCF50767.1 - 1.3 8.1 11.6 1.8 7.7 2.7 2.5 2 1 0 2 2 2 0 Invariant surface glycoprotein Viral_P18 PF04521.13 CCF50767.1 - 1.4 8.7 4.5 7.9 6.3 0.2 2.6 3 0 0 3 3 3 0 ssRNA positive strand viral 18kD cysteine rich protein DUF745 PF05335.13 CCF50767.1 - 1.9 8.2 16.7 0.15 11.7 5.0 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF745) Spectrin PF00435.21 CCF50767.1 - 2.3 8.8 12.0 1.9 9.0 0.5 3.3 2 1 1 3 3 3 0 Spectrin repeat Ufd2P_core PF10408.9 CCF50767.1 - 3 6.3 10.9 0.033 12.8 0.5 2.2 2 1 1 3 3 3 0 Ubiquitin elongating factor core DUF4094 PF13334.6 CCF50767.1 - 3.3 8.2 8.8 2.2 8.7 3.8 3.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4094) Transposase_20 PF02371.16 CCF50768.1 - 0.065 13.6 0.0 0.16 12.3 0.0 1.6 1 0 0 1 1 1 0 Transposase IS116/IS110/IS902 family DUF3535 PF12054.8 CCF50770.1 - 1.8e-108 363.6 0.3 2.3e-105 353.4 0.2 3.7 4 0 0 4 4 4 2 Domain of unknown function (DUF3535) SNF2_N PF00176.23 CCF50770.1 - 3e-60 203.8 0.0 1.3e-59 201.7 0.0 1.9 2 1 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 CCF50770.1 - 2.3e-16 60.1 0.0 8.2e-16 58.3 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HEAT PF02985.22 CCF50770.1 - 6.4e-10 38.4 35.4 0.086 13.1 0.0 11.4 12 0 0 12 12 11 5 HEAT repeat Vac14_Fab1_bd PF12755.7 CCF50770.1 - 6.9e-06 26.6 0.3 0.26 11.9 0.0 3.0 2 0 0 2 2 2 2 Vacuolar 14 Fab1-binding region DUF3385 PF11865.8 CCF50770.1 - 0.029 14.3 2.2 0.82 9.6 0.4 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3385) HEAT_EZ PF13513.6 CCF50770.1 - 0.03 14.8 27.4 5 7.7 1.0 10.3 10 0 0 10 10 10 0 HEAT-like repeat BLM10_mid PF16507.5 CCF50770.1 - 0.035 12.8 0.2 0.63 8.6 0.0 2.2 2 0 0 2 2 2 0 Proteasome-substrate-size regulator, mid region TAF6_C PF07571.13 CCF50770.1 - 0.039 14.3 0.0 32 5.0 0.0 5.3 5 0 0 5 5 5 0 TAF6 C-terminal HEAT repeat domain UME PF08064.13 CCF50770.1 - 0.049 13.5 5.3 9.5 6.2 0.6 5.2 5 1 0 5 5 5 0 UME (NUC010) domain HEAT_2 PF13646.6 CCF50770.1 - 0.062 13.7 27.4 3.3 8.2 0.1 8.8 8 1 1 9 9 9 0 HEAT repeats Cnd1 PF12717.7 CCF50770.1 - 0.62 10.1 7.2 5.2 7.1 0.2 4.4 5 0 0 5 5 5 0 non-SMC mitotic condensation complex subunit 1 Ribosomal_L27A PF00828.19 CCF50771.1 - 1.3e-35 122.9 0.1 4.1e-35 121.2 0.0 1.7 2 0 0 2 2 2 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A MerR_1 PF13411.6 CCF50771.1 - 0.1 12.7 0.0 0.27 11.4 0.0 1.7 2 0 0 2 2 2 0 MerR HTH family regulatory protein CtnDOT_TraJ PF07863.11 CCF50771.1 - 0.21 12.2 0.3 0.53 11.0 0.0 1.7 2 0 0 2 2 2 0 Homologues of TraJ from Bacteroides conjugative transposon Utp21 PF04192.12 CCF50772.1 - 4.6e-48 163.7 0.2 9e-48 162.8 0.0 1.5 2 0 0 2 2 2 1 Utp21 specific WD40 associated putative domain ANAPC4_WD40 PF12894.7 CCF50772.1 - 3.9e-10 39.9 0.0 0.012 15.9 0.0 6.2 3 2 3 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 CCF50772.1 - 5.2e-09 36.6 17.0 0.078 13.9 0.1 8.8 9 1 0 9 9 9 3 WD domain, G-beta repeat PQQ_2 PF13360.6 CCF50772.1 - 4.1e-05 23.3 0.7 0.0022 17.6 0.1 2.7 2 0 0 2 2 2 1 PQQ-like domain DEAD PF00270.29 CCF50773.1 - 5.3e-45 153.3 0.0 9.6e-45 152.5 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CCF50773.1 - 5.8e-23 81.3 0.0 3e-22 79.1 0.0 2.2 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 CCF50773.1 - 1.5e-18 66.8 0.2 3.7e-18 65.5 0.2 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 CCF50773.1 - 0.0029 17.7 0.0 0.0049 16.9 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Hist_deacetyl PF00850.19 CCF50774.1 - 9.2e-74 248.7 0.0 1.7e-73 247.8 0.0 1.5 1 1 0 1 1 1 1 Histone deacetylase domain Fungal_trans PF04082.18 CCF50776.1 - 9.6e-14 51.0 0.3 2e-13 50.0 0.3 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF50776.1 - 3.7e-05 23.8 10.2 8.6e-05 22.6 10.2 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CDC45 PF02724.14 CCF50776.1 - 0.068 11.5 10.5 0.16 10.2 10.5 1.5 1 0 0 1 1 1 0 CDC45-like protein PBP1_TM PF14812.6 CCF50776.1 - 6.7 7.2 18.9 12 6.3 13.6 3.2 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Methyltransf_28 PF02636.17 CCF50777.1 - 7.4e-75 252.0 0.0 1.2e-74 251.3 0.0 1.3 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase Amino_oxidase PF01593.24 CCF50777.1 - 6.4e-34 118.0 0.0 8.8e-34 117.6 0.0 1.2 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 CCF50777.1 - 7.1e-12 45.4 0.2 2.2e-11 43.8 0.1 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CCF50777.1 - 4.6e-06 26.4 0.7 0.00011 21.9 0.7 2.7 1 1 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.14 CCF50777.1 - 6e-05 21.9 0.1 0.033 12.9 0.1 2.4 2 0 0 2 2 2 2 HI0933-like protein Pyr_redox_2 PF07992.14 CCF50777.1 - 0.00014 21.2 4.1 0.25 10.5 0.0 3.5 4 0 0 4 4 4 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CCF50777.1 - 0.00027 21.0 1.2 0.024 14.7 0.0 2.4 2 0 0 2 2 2 1 FAD-NAD(P)-binding Trp_halogenase PF04820.14 CCF50777.1 - 0.0074 15.2 0.0 0.85 8.4 0.0 2.2 2 0 0 2 2 2 2 Tryptophan halogenase Pyr_redox PF00070.27 CCF50777.1 - 0.035 14.7 0.2 13 6.4 0.0 3.0 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 CCF50777.1 - 0.1 11.8 0.0 0.23 10.6 0.0 1.5 1 0 0 1 1 1 0 Thi4 family UCR_14kD PF02271.16 CCF50778.1 - 5.1e-39 132.3 1.1 6e-39 132.1 1.1 1.0 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase complex 14kD subunit YIF1 PF03878.15 CCF50779.1 - 4.8e-93 311.1 0.2 6.1e-93 310.7 0.2 1.1 1 0 0 1 1 1 1 YIF1 eIF-1a PF01176.19 CCF50780.1 - 9.2e-22 76.6 0.0 1.3e-21 76.1 0.0 1.2 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 Cwf_Cwc_15 PF04889.12 CCF50780.1 - 0.14 11.9 6.3 0.15 11.8 6.3 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Solute_trans_a PF03619.16 CCF50781.1 - 4.6e-92 308.3 10.3 5.5e-92 308.0 10.3 1.1 1 0 0 1 1 1 1 Organic solute transporter Ostalpha Med3 PF11593.8 CCF50781.1 - 1.3 8.1 3.4 1.9 7.6 3.4 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Mit_ribos_Mrp51 PF11709.8 CCF50782.1 - 7.4e-13 48.8 1.0 3.1e-12 46.8 1.0 1.9 1 1 0 1 1 1 1 Mitochondrial ribosomal protein subunit OMPdecase PF00215.24 CCF50783.1 - 2.2e-72 243.3 0.0 2.8e-72 243.0 0.0 1.1 1 0 0 1 1 1 1 Orotidine 5'-phosphate decarboxylase / HUMPS family HhH-GPD PF00730.25 CCF50784.1 - 4.3e-18 65.7 0.0 7.8e-18 64.9 0.0 1.4 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 CCF50784.1 - 2.1e-08 33.6 0.0 9e-08 31.6 0.0 2.0 2 0 0 2 2 2 1 Helix-hairpin-helix motif HHH_5 PF14520.6 CCF50784.1 - 0.061 13.9 0.1 0.27 11.9 0.0 2.1 2 0 0 2 2 2 0 Helix-hairpin-helix domain GTP_EFTU PF00009.27 CCF50785.1 - 3.6e-42 144.1 0.0 7.2e-42 143.1 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 CCF50785.1 - 1.4e-11 44.7 0.0 3.4e-11 43.4 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain HBS1_N PF08938.10 CCF50785.1 - 2.4e-10 40.6 3.1 5.5e-10 39.4 3.1 1.6 1 0 0 1 1 1 1 HBS1 N-terminus GTP_EFTU_D2 PF03144.25 CCF50785.1 - 1.2e-07 32.0 0.7 3.2e-07 30.6 0.7 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 CCF50785.1 - 9.1e-07 29.0 0.0 1.5e-05 25.0 0.0 2.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase DUF1296 PF06972.11 CCF50785.1 - 0.015 15.4 0.2 0.047 13.8 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1296) SRPRB PF09439.10 CCF50785.1 - 0.033 13.6 0.0 1.9 7.9 0.0 2.3 1 1 0 2 2 2 0 Signal recognition particle receptor beta subunit GTP_EFTU_D4 PF14578.6 CCF50785.1 - 0.18 11.7 1.7 0.61 10.0 1.7 1.9 1 0 0 1 1 1 0 Elongation factor Tu domain 4 YqeY PF09424.10 CCF50786.1 - 2.2e-15 57.0 4.2 3e-15 56.5 4.2 1.1 1 0 0 1 1 1 1 Yqey-like protein CM_2 PF01817.21 CCF50786.1 - 0.02 15.2 1.3 0.055 13.8 0.7 1.8 2 0 0 2 2 2 0 Chorismate mutase type II Kinesin PF00225.23 CCF50787.1 - 1.1e-112 376.3 1.7 1.4e-112 376.0 0.0 2.1 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 CCF50787.1 - 1.8e-27 96.1 0.0 8.1e-27 94.0 0.0 2.3 1 0 0 1 1 1 1 Microtubule binding DUF465 PF04325.13 CCF50787.1 - 5.5e-10 39.1 1.2 5.5e-10 39.1 1.2 4.2 4 0 0 4 4 4 1 Protein of unknown function (DUF465) Dynactin_p62 PF05502.13 CCF50787.1 - 0.00015 20.7 3.6 0.00015 20.7 3.6 2.6 1 1 0 2 2 2 1 Dynactin p62 family ATG16 PF08614.11 CCF50787.1 - 0.00023 21.4 13.8 0.00023 21.4 13.8 5.7 1 1 3 5 5 5 1 Autophagy protein 16 (ATG16) DUF4201 PF13870.6 CCF50787.1 - 0.0017 18.1 11.7 0.0017 18.1 11.7 5.8 4 2 1 5 5 5 2 Domain of unknown function (DUF4201) TPR_MLP1_2 PF07926.12 CCF50787.1 - 0.005 16.9 14.3 0.005 16.9 14.3 6.3 3 1 2 5 5 5 2 TPR/MLP1/MLP2-like protein Sox_N PF12444.8 CCF50787.1 - 0.085 14.0 0.2 1.7 9.8 0.0 3.3 2 0 0 2 2 2 0 Sox developmental protein N terminal Filament PF00038.21 CCF50787.1 - 0.36 10.4 76.8 0.045 13.3 44.6 4.2 3 1 1 4 4 4 0 Intermediate filament protein Fungal_trans PF04082.18 CCF50789.1 - 3e-20 72.4 0.0 4.7e-20 71.7 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF50789.1 - 1.3e-09 38.0 1.6 2.3e-09 37.2 1.6 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain GP40 PF11025.8 CCF50790.1 - 0.11 12.3 0.1 0.75 9.5 0.0 1.9 2 0 0 2 2 2 0 Glycoprotein GP40 of Cryptosporidium DUF1425 PF07233.12 CCF50790.1 - 0.14 12.0 0.4 1.2 9.1 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1425) Med3 PF11593.8 CCF50790.1 - 0.31 10.2 2.0 0.45 9.7 2.0 1.3 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal COX15-CtaA PF02628.15 CCF50791.1 - 0.018 14.1 2.9 0.02 13.9 1.7 1.5 1 1 1 2 2 2 0 Cytochrome oxidase assembly protein Ribosomal_S21 PF01165.20 CCF50792.1 - 6.8e-11 41.7 7.5 6.8e-11 41.7 7.5 1.6 2 0 0 2 2 2 1 Ribosomal protein S21 MIF4G PF02854.19 CCF50793.1 - 7.7e-05 22.4 0.0 0.00015 21.5 0.0 1.4 1 0 0 1 1 1 1 MIF4G domain COesterase PF00135.28 CCF50795.1 - 2.1e-93 314.0 0.0 2.6e-93 313.6 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 CCF50795.1 - 4.2e-11 43.1 0.1 1.1e-10 41.8 0.1 1.7 2 0 0 2 2 2 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 CCF50795.1 - 3.7e-06 26.6 0.0 7.4e-06 25.6 0.0 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family Spike_torovirin PF17072.5 CCF50795.1 - 0.023 11.9 0.1 0.031 11.5 0.1 1.1 1 0 0 1 1 1 0 Torovirinae spike glycoprotein Binary_toxB PF03495.14 CCF50795.1 - 0.06 13.6 0.2 14 6.0 0.0 2.7 2 0 0 2 2 2 0 Clostridial binary toxin B/anthrax toxin PA Ca-binding domain Adaptin_N PF01602.20 CCF50797.1 - 6e-127 424.4 9.8 7.4e-127 424.1 9.8 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 CCF50797.1 - 7.8e-58 195.1 12.2 8e-58 195.0 1.7 2.9 4 0 0 4 4 4 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 CCF50797.1 - 8.6e-16 58.1 2.9 5.7e-07 29.8 0.2 4.4 2 2 2 4 4 4 3 HEAT repeats HEAT PF02985.22 CCF50797.1 - 1.3e-09 37.5 0.4 0.022 15.0 0.0 4.7 3 0 0 3 3 3 3 HEAT repeat Cnd3 PF12719.7 CCF50797.1 - 3.5e-06 26.4 0.1 0.0096 15.1 0.0 2.5 3 0 0 3 3 3 2 Nuclear condensing complex subunits, C-term domain CLASP_N PF12348.8 CCF50797.1 - 4.9e-05 23.0 0.3 0.72 9.4 0.0 3.5 2 1 1 3 3 3 2 CLASP N terminal Arm PF00514.23 CCF50797.1 - 0.0003 20.7 2.9 0.95 9.6 0.0 4.7 4 0 0 4 4 4 1 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 CCF50797.1 - 0.0012 19.3 2.4 4.6 7.8 0.0 4.5 5 0 0 5 5 5 2 HEAT-like repeat RTP1_C1 PF10363.9 CCF50797.1 - 0.0048 17.1 2.1 1.8 8.7 0.1 3.4 2 1 1 3 3 3 1 Required for nuclear transport of RNA pol II C-terminus 1 Arm_2 PF04826.13 CCF50797.1 - 0.019 14.4 0.1 0.044 13.2 0.1 1.6 1 0 0 1 1 1 0 Armadillo-like RasGEF_N_2 PF14663.6 CCF50797.1 - 0.28 11.6 3.3 3.8 8.0 0.1 3.3 3 1 1 4 4 4 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain DHHC PF01529.20 CCF50798.1 - 1.7e-31 109.1 5.9 1.7e-31 109.1 5.9 2.0 2 1 0 2 2 2 1 DHHC palmitoyltransferase Ank_2 PF12796.7 CCF50798.1 - 1.5e-28 99.2 0.8 3.6e-13 49.9 0.0 3.5 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CCF50798.1 - 6e-20 71.3 3.8 1.4e-06 28.7 0.2 5.3 2 2 3 5 5 5 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 CCF50798.1 - 8.8e-19 67.3 3.1 2e-06 27.9 0.0 5.3 2 2 3 5 5 5 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 CCF50798.1 - 1.8e-16 58.5 1.5 0.001 19.3 0.1 5.3 4 0 0 4 4 4 4 Ankyrin repeat Ank PF00023.30 CCF50798.1 - 1.6e-15 56.7 8.4 0.0057 17.1 0.0 5.8 6 0 0 6 6 6 4 Ankyrin repeat gag_pre-integrs PF13976.6 CCF50799.1 - 0.02 14.7 0.2 0.038 13.8 0.1 1.7 1 1 1 2 2 2 0 GAG-pre-integrase domain DUF155 PF02582.14 CCF50800.1 - 7.6e-49 166.2 0.0 1.1e-48 165.7 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 TRAPPC9-Trs120 PF08626.11 CCF50801.1 - 2.9e-155 518.5 0.0 1.4e-154 516.2 0.0 2.1 1 1 0 1 1 1 1 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit GATA PF00320.27 CCF50803.1 - 8.2e-18 63.7 1.9 1.6e-17 62.8 1.9 1.5 1 0 0 1 1 1 1 GATA zinc finger DUF1752 PF08550.10 CCF50803.1 - 3e-13 49.3 1.3 6.5e-13 48.3 1.3 1.6 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) ABC_tran PF00005.27 CCF50804.1 - 9.9e-47 158.9 0.0 7.5e-26 91.3 0.0 3.6 2 2 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 CCF50804.1 - 6.3e-15 55.8 0.6 0.024 14.5 0.0 4.3 3 1 1 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CCF50804.1 - 1.3e-11 44.4 0.0 0.0004 19.9 0.0 3.4 3 0 0 3 3 3 3 RecF/RecN/SMC N terminal domain Chromo PF00385.24 CCF50804.1 - 1.1e-10 41.2 1.0 2.4e-10 40.1 1.0 1.6 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain AAA_23 PF13476.6 CCF50804.1 - 9e-07 29.6 0.0 0.038 14.5 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_29 PF13555.6 CCF50804.1 - 6.5e-06 25.8 0.2 0.067 12.9 0.1 2.9 2 0 0 2 2 2 2 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 CCF50804.1 - 3.4e-05 23.9 0.4 0.015 15.4 0.0 3.3 2 1 0 2 2 2 1 50S ribosome-binding GTPase AAA_28 PF13521.6 CCF50804.1 - 0.00018 21.8 1.1 0.66 10.2 0.0 3.5 3 0 0 3 3 3 2 AAA domain AAA_16 PF13191.6 CCF50804.1 - 0.00027 21.4 0.0 1.2 9.5 0.0 3.7 3 0 0 3 3 3 1 AAA ATPase domain DUF87 PF01935.17 CCF50804.1 - 0.00053 20.2 0.1 0.2 11.7 0.0 2.9 2 0 0 2 2 2 1 Helicase HerA, central domain AAA_22 PF13401.6 CCF50804.1 - 0.00067 19.9 0.0 1.1 9.5 0.0 3.5 4 0 0 4 4 4 1 AAA domain HEAT_2 PF13646.6 CCF50804.1 - 0.0008 19.7 6.8 1.4 9.4 0.3 4.8 2 2 2 4 4 4 1 HEAT repeats MeaB PF03308.16 CCF50804.1 - 0.00095 18.2 0.4 0.17 10.8 0.1 2.7 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB RsgA_GTPase PF03193.16 CCF50804.1 - 0.0025 17.7 0.5 0.067 13.1 0.1 2.5 2 0 0 2 2 2 1 RsgA GTPase AAA_30 PF13604.6 CCF50804.1 - 0.0028 17.4 1.3 1.1 8.9 0.0 3.8 4 0 0 4 4 3 1 AAA domain HEAT_EZ PF13513.6 CCF50804.1 - 0.0059 17.1 4.5 0.39 11.3 0.0 4.8 6 0 0 6 6 5 1 HEAT-like repeat AAA_18 PF13238.6 CCF50804.1 - 0.012 16.2 0.0 2.6 8.6 0.0 3.1 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 CCF50804.1 - 0.027 14.2 0.1 8.3 6.1 0.0 3.3 3 0 0 3 3 3 0 AAA domain RNA_helicase PF00910.22 CCF50804.1 - 0.039 14.3 0.0 3.2 8.2 0.0 3.6 3 0 0 3 3 3 0 RNA helicase CLASP_N PF12348.8 CCF50804.1 - 0.049 13.2 0.0 8.5 5.9 0.0 3.4 3 0 0 3 3 3 0 CLASP N terminal Tudor-knot PF11717.8 CCF50804.1 - 0.052 13.5 0.6 0.12 12.3 0.6 1.6 1 0 0 1 1 1 0 RNA binding activity-knot of a chromodomain NACHT PF05729.12 CCF50804.1 - 0.085 12.8 0.1 12 5.8 0.0 2.5 2 0 0 2 2 2 0 NACHT domain AAA_33 PF13671.6 CCF50804.1 - 0.11 12.6 0.1 9.5 6.4 0.0 2.9 2 1 0 2 2 2 0 AAA domain cobW PF02492.19 CCF50804.1 - 0.13 11.9 0.2 16 5.0 0.0 3.3 3 0 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain AAA_15 PF13175.6 CCF50804.1 - 0.15 11.7 0.3 19 4.8 0.1 2.7 2 1 0 2 2 2 0 AAA ATPase domain Dynamin_N PF00350.23 CCF50804.1 - 0.15 12.1 0.0 2.3 8.3 0.0 2.6 2 0 0 2 2 2 0 Dynamin family Sfi1 PF08457.10 CCF50805.1 - 6.2e-30 104.3 134.9 3.4e-18 65.5 79.5 5.3 1 1 1 3 3 3 3 Sfi1 spindle body protein Pkinase PF00069.25 CCF50807.1 - 5.2e-68 229.3 0.0 7.6e-68 228.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF50807.1 - 3.2e-44 151.2 0.0 1.3e-43 149.2 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase Ras_bdg_2 PF14847.6 CCF50807.1 - 1.8e-20 73.2 0.0 3.1e-20 72.3 0.0 1.4 1 0 0 1 1 1 1 Ras-binding domain of Byr2 SAM_2 PF07647.17 CCF50807.1 - 1e-10 41.5 0.0 2.4e-10 40.4 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 CCF50807.1 - 2e-10 41.0 0.0 4.8e-10 39.7 0.0 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Kinase-like PF14531.6 CCF50807.1 - 3.3e-06 26.6 0.0 1.8e-05 24.2 0.0 1.9 2 0 0 2 2 2 1 Kinase-like SAM_4 PF18017.1 CCF50807.1 - 0.00067 19.6 0.0 0.0014 18.5 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Pkinase_fungal PF17667.1 CCF50807.1 - 0.017 14.0 0.7 0.053 12.3 0.0 2.2 2 0 0 2 2 2 0 Fungal protein kinase Kdo PF06293.14 CCF50807.1 - 0.18 11.1 0.0 0.36 10.1 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family ThuA PF06283.11 CCF50808.1 - 3e-56 191.0 2.4 3.7e-56 190.7 2.4 1.1 1 0 0 1 1 1 1 Trehalose utilisation UTP15_C PF09384.10 CCF50809.1 - 1.5e-45 154.5 0.0 2.5e-45 153.8 0.0 1.4 1 0 0 1 1 1 1 UTP15 C terminal WD40 PF00400.32 CCF50809.1 - 1.5e-25 88.9 1.2 7.3e-08 33.0 0.0 5.8 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF50809.1 - 2.7e-06 27.6 0.0 0.4 11.0 0.0 3.7 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CCF50809.1 - 0.011 14.7 0.0 0.14 11.1 0.0 2.5 2 1 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Glyco_hydro_18 PF00704.28 CCF50810.1 - 2.1e-84 283.9 1.6 2.9e-84 283.5 1.6 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 DUF2034 PF10356.9 CCF50810.1 - 0.04 13.4 0.0 0.12 11.8 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2034) Med3 PF11593.8 CCF50810.1 - 7.9 5.6 13.5 11 5.1 13.5 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal QRPTase_C PF01729.19 CCF50811.1 - 4e-51 173.2 0.1 4.9e-51 172.8 0.1 1.1 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, C-terminal domain QRPTase_N PF02749.16 CCF50811.1 - 1.4e-17 63.6 0.0 4.7e-17 61.8 0.0 2.0 1 1 0 1 1 1 1 Quinolinate phosphoribosyl transferase, N-terminal domain KDGP_aldolase PF07071.11 CCF50811.1 - 0.059 13.2 0.0 0.11 12.3 0.0 1.5 2 0 0 2 2 2 0 KDGP aldolase TP6A_N PF04406.14 CCF50812.1 - 1e-05 25.4 0.0 2.4e-05 24.2 0.0 1.6 1 0 0 1 1 1 1 Type IIB DNA topoisomerase DUF2399 PF09664.10 CCF50812.1 - 0.0006 19.8 0.1 0.00092 19.2 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function C-terminus (DUF2399) SR-25 PF10500.9 CCF50812.1 - 0.99 9.0 10.0 1.6 8.3 10.0 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein ORC6 PF05460.13 CCF50812.1 - 1.3 8.2 5.9 1.9 7.7 5.9 1.2 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) PAP2 PF01569.21 CCF50813.1 - 4.6e-30 104.1 1.5 4.6e-30 104.1 1.5 2.1 2 0 0 2 2 2 1 PAP2 superfamily Saf_2TM PF18303.1 CCF50813.1 - 0.0083 15.7 0.3 0.014 15.0 0.3 1.3 1 0 0 1 1 1 1 SAVED-fused 2TM effector domain DotU PF09850.9 CCF50813.1 - 0.19 11.4 3.7 0.54 9.9 0.1 2.2 1 1 1 2 2 2 0 Type VI secretion system protein DotU Foamy_virus_ENV PF03408.14 CCF50813.1 - 0.23 9.3 0.2 0.3 8.9 0.2 1.1 1 0 0 1 1 1 0 Foamy virus envelope protein PAP2_3 PF14378.6 CCF50813.1 - 0.34 10.6 12.6 0.68 9.6 11.0 2.4 1 1 0 1 1 1 0 PAP2 superfamily Ytca PF17090.5 CCF50813.1 - 4.5 7.9 5.8 0.96 10.0 0.4 2.5 2 1 1 3 3 3 0 Uncharacterised protein family YbgT_YccB PF08173.11 CCF50813.1 - 5.6 7.2 6.8 0.77 9.9 0.7 2.5 2 0 0 2 2 2 0 Membrane bound YbgT-like protein APG6 PF04111.12 CCF50814.1 - 1.1e-63 214.4 0.0 2e-63 213.6 0.0 1.4 1 0 0 1 1 1 1 Apg6 BARA domain APG6_N PF17675.1 CCF50814.1 - 5.3e-38 130.6 11.9 7.7e-38 130.0 11.9 1.3 1 0 0 1 1 1 1 Apg6 coiled-coil region DB_JBP1 PF18526.1 CCF50814.1 - 0.11 12.4 0.2 0.25 11.3 0.2 1.5 1 0 0 1 1 1 0 Thymine dioxygenase JBP1 DNA-binding domain GLTSCR1 PF15249.6 CCF50815.1 - 2.5e-10 40.7 0.3 2.5e-10 40.7 0.3 3.0 2 1 1 3 3 3 1 Conserved region of unknown function on GLTSCR protein WHEP-TRS PF00458.20 CCF50815.1 - 0.019 15.1 0.9 0.097 12.8 0.9 2.2 1 0 0 1 1 1 0 WHEP-TRS domain PEMT PF04191.13 CCF50816.1 - 0.0023 18.3 1.1 0.0044 17.4 0.4 1.8 2 0 0 2 2 2 1 Phospholipid methyltransferase ICMT PF04140.14 CCF50816.1 - 0.012 16.0 0.0 0.87 10.0 0.0 2.5 1 1 0 1 1 1 0 Isoprenylcysteine carboxyl methyltransferase (ICMT) family DUF202 PF02656.15 CCF50816.1 - 0.23 11.9 5.0 4.6 7.8 0.5 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF202) FixS PF03597.15 CCF50816.1 - 7.1 6.4 7.0 0.73 9.6 0.7 2.6 3 0 0 3 3 3 0 Cytochrome oxidase maturation protein cbb3-type Lung_7-TM_R PF06814.13 CCF50817.1 - 4e-50 170.7 18.5 1.4e-49 168.9 18.5 1.8 1 1 0 1 1 1 1 Lung seven transmembrane receptor DUF4307 PF14155.6 CCF50817.1 - 6.7 6.6 6.4 8.4 6.3 0.0 4.1 5 0 0 5 5 5 0 Domain of unknown function (DUF4307) Ribosomal_L32p PF01783.23 CCF50818.1 - 2.3e-15 56.5 6.2 3.7e-15 55.9 6.2 1.3 1 0 0 1 1 1 1 Ribosomal L32p protein family zf-ribbon_3 PF13248.6 CCF50818.1 - 0.0006 19.1 1.2 0.00098 18.5 1.2 1.3 1 0 0 1 1 1 1 zinc-ribbon domain zinc-ribbons_6 PF07191.12 CCF50818.1 - 0.041 13.9 0.4 0.06 13.3 0.4 1.2 1 0 0 1 1 1 0 zinc-ribbons AlaDh_PNT_N PF05222.15 CCF50819.1 - 8.1e-28 97.4 0.0 1.3e-27 96.7 0.0 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain AlaDh_PNT_C PF01262.21 CCF50819.1 - 0.036 13.3 0.0 0.052 12.8 0.0 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain RRM_1 PF00076.22 CCF50820.1 - 1.7e-05 24.6 0.0 2.7e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Amidase02_C PF12123.8 CCF50820.1 - 0.066 12.9 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 N-acetylmuramoyl-l-alanine amidase Presenilin PF01080.17 CCF50820.1 - 0.86 8.3 1.9 1.1 8.0 1.9 1.1 1 0 0 1 1 1 0 Presenilin Pex14_N PF04695.13 CCF50820.1 - 3.7 8.2 14.4 9.4 6.9 14.4 1.6 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region tRNA-synt_2 PF00152.20 CCF50821.1 - 1.1e-78 264.5 0.1 1.4e-78 264.2 0.1 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 CCF50821.1 - 2.2e-05 24.3 0.0 4.8e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 CCF50821.1 - 0.12 11.8 0.2 4.7 6.6 0.0 2.3 2 0 0 2 2 2 0 tRNA synthetases class II core domain (F) zf-C2H2 PF00096.26 CCF50823.1 - 3.3e-09 36.7 15.4 3e-05 24.2 1.7 3.8 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 CCF50823.1 - 2.6e-06 27.6 2.9 2.6e-06 27.6 2.9 3.7 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_6 PF13912.6 CCF50823.1 - 0.00098 19.1 0.6 0.00098 19.1 0.6 2.3 2 0 0 2 2 2 1 C2H2-type zinc finger zf-met PF12874.7 CCF50823.1 - 0.0014 18.9 2.6 0.016 15.6 0.3 3.5 3 0 0 3 3 3 1 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.6 CCF50823.1 - 0.0017 19.0 1.0 0.0017 19.0 1.0 3.8 3 0 0 3 3 3 1 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 CCF50823.1 - 0.0021 18.3 0.1 0.0021 18.3 0.1 2.6 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding FOXP-CC PF16159.5 CCF50823.1 - 0.064 13.9 14.3 0.098 13.3 0.3 3.3 1 1 2 3 3 3 0 FOXP coiled-coil domain MutS_V PF00488.21 CCF50824.1 - 5.4e-57 192.9 0.0 4e-56 190.0 0.0 2.2 1 1 0 1 1 1 1 MutS domain V MutS_III PF05192.18 CCF50824.1 - 4.1e-36 125.0 0.1 7.3e-36 124.2 0.1 1.4 1 0 0 1 1 1 1 MutS domain III MutS_I PF01624.20 CCF50824.1 - 2.9e-22 79.0 0.0 6e-22 78.0 0.0 1.6 1 0 0 1 1 1 1 MutS domain I MutS_II PF05188.17 CCF50824.1 - 4.4e-12 46.5 0.0 5.3e-11 42.9 0.0 2.5 2 0 0 2 2 2 1 MutS domain II MutS_IV PF05190.18 CCF50824.1 - 2.1e-06 28.0 0.0 5e-06 26.8 0.0 1.6 1 0 0 1 1 1 1 MutS family domain IV Prenyltrans PF00432.21 CCF50825.1 - 1.3e-46 156.0 9.7 4.1e-09 36.0 0.0 6.0 6 0 0 6 6 6 5 Prenyltransferase and squalene oxidase repeat SQHop_cyclase_C PF13243.6 CCF50825.1 - 0.0022 17.2 0.0 0.025 13.7 0.0 2.0 1 1 1 2 2 2 1 Squalene-hopene cyclase C-terminal domain SQHop_cyclase_N PF13249.6 CCF50825.1 - 0.012 14.8 0.0 9.1 5.3 0.0 3.6 1 1 2 4 4 4 0 Squalene-hopene cyclase N-terminal domain Acetyltransf_1 PF00583.25 CCF50826.1 - 8.6e-09 35.6 0.0 1.1e-08 35.3 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CCF50826.1 - 9.5e-07 28.8 0.0 1.5e-06 28.2 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CCF50826.1 - 8.1e-06 25.7 0.0 1.4e-05 25.0 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_7 PF13508.7 CCF50826.1 - 3e-05 24.4 0.1 5.4e-05 23.5 0.0 1.5 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 CCF50826.1 - 0.0013 18.8 0.1 0.002 18.2 0.1 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain RVT_2 PF07727.14 CCF50827.1 - 8.1e-48 163.2 1.0 1.3e-47 162.5 1.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 CCF50827.1 - 2.2e-09 37.5 0.2 4.4e-09 36.6 0.2 1.5 1 0 0 1 1 1 1 Integrase core domain RNA_pol_Rpb2_6 PF00562.28 CCF50832.1 - 1.3e-124 416.2 0.4 4.2e-124 414.6 0.1 2.0 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 CCF50832.1 - 1e-65 221.1 0.0 1.5e-65 220.6 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_2 PF04561.14 CCF50832.1 - 1.5e-49 168.3 0.1 4.5e-49 166.7 0.0 1.9 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_7 PF04560.20 CCF50832.1 - 1.2e-30 105.8 0.1 5.3e-30 103.7 0.1 2.2 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_3 PF04565.16 CCF50832.1 - 8.6e-25 86.7 0.1 2.4e-24 85.3 0.1 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_4 PF04566.13 CCF50832.1 - 3.9e-23 81.5 1.1 8.1e-23 80.5 0.3 2.1 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_5 PF04567.17 CCF50832.1 - 1.4e-20 73.6 0.4 5.3e-20 71.7 0.4 2.1 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 LIM_bind PF01803.16 CCF50832.1 - 0.08 12.5 0.1 1 8.9 0.1 2.1 2 0 0 2 2 2 0 LIM-domain binding protein RNA_pol_Rpb2_45 PF10385.9 CCF50832.1 - 0.1 12.9 0.1 0.99 9.7 0.0 2.5 2 0 0 2 2 2 0 RNA polymerase beta subunit external 1 domain Zn_Tnp_IS1595 PF12760.7 CCF50832.1 - 0.14 12.1 0.3 0.31 11.1 0.3 1.5 1 0 0 1 1 1 0 Transposase zinc-ribbon domain CWC25 PF12542.8 CCF50833.1 - 1.6e-25 90.0 1.7 1.6e-25 90.0 1.7 4.2 3 2 1 4 4 4 1 Pre-mRNA splicing factor Cir_N PF10197.9 CCF50833.1 - 5e-13 49.0 14.5 5e-13 49.0 14.5 5.4 5 0 0 5 5 5 1 N-terminal domain of CBF1 interacting co-repressor CIR BTB PF00651.31 CCF50834.1 - 9.3e-08 32.3 0.0 0.0022 18.2 0.0 2.3 2 0 0 2 2 2 2 BTB/POZ domain ABC2_membrane PF01061.24 CCF50835.1 - 1.7e-43 148.5 17.3 1.7e-43 148.5 17.3 1.6 2 0 0 2 2 2 1 ABC-2 type transporter ABC2_membrane_3 PF12698.7 CCF50835.1 - 0.0014 17.9 18.3 0.0014 17.9 18.3 1.6 1 1 0 1 1 1 1 ABC-2 family transporter protein ABC2_membrane_2 PF12679.7 CCF50835.1 - 0.063 12.5 6.6 0.047 13.0 4.7 1.7 1 1 1 2 2 2 0 ABC-2 family transporter protein ATPase_gene1 PF09527.10 CCF50835.1 - 3 8.1 11.8 1.4 9.2 0.8 3.0 2 0 0 2 2 2 0 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter ICL PF00463.21 CCF50836.1 - 5.8e-255 846.7 1.5 6.7e-255 846.5 1.5 1.0 1 0 0 1 1 1 1 Isocitrate lyase family PEP_mutase PF13714.6 CCF50836.1 - 5.6e-09 35.8 0.0 9.7e-09 35.0 0.0 1.4 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase Arg_repressor_C PF02863.18 CCF50836.1 - 0.15 11.9 0.1 0.32 10.9 0.1 1.5 1 0 0 1 1 1 0 Arginine repressor, C-terminal domain Ribo_biogen_C PF04034.13 CCF50837.1 - 3.9e-47 159.1 0.0 5.5e-47 158.6 0.0 1.2 1 0 0 1 1 1 1 Ribosome biogenesis protein, C-terminal RLI PF04068.15 CCF50837.1 - 2.3e-15 56.1 0.1 3.9e-15 55.4 0.1 1.4 1 0 0 1 1 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI Trypan_PARP PF05887.11 CCF50837.1 - 0.02 14.9 0.4 0.036 14.0 0.4 1.4 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) DUF4820 PF16091.5 CCF50837.1 - 7.3 5.9 9.5 4.3 6.6 0.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4820) MFS_1 PF07690.16 CCF50840.1 - 1.4e-29 103.2 45.4 2e-29 102.6 45.4 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily TB2_DP1_HVA22 PF03134.19 CCF50840.1 - 0.13 12.2 3.9 0.27 11.2 0.3 3.0 2 0 0 2 2 2 0 TB2/DP1, HVA22 family ATP-grasp_6 PF18419.1 CCF50840.1 - 0.15 11.7 0.0 0.25 11.0 0.0 1.3 1 0 0 1 1 1 0 ATP-grasp-like domain OATP PF03137.20 CCF50840.1 - 7.8 4.7 18.2 54 1.9 18.1 2.3 1 1 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family His_Phos_2 PF00328.22 CCF50841.1 - 1.1e-46 160.0 0.0 1.6e-46 159.4 0.0 1.3 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) adh_short PF00106.25 CCF50842.1 - 2.5e-24 85.8 0.0 6e-23 81.3 0.0 2.0 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF50842.1 - 1.8e-22 80.1 0.0 4e-21 75.6 0.0 2.0 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase 3HCDH_N PF02737.18 CCF50842.1 - 0.022 14.6 0.0 0.033 14.1 0.0 1.2 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Ribosomal_L41 PF05162.13 CCF50843.1 - 4.4e-11 42.6 32.5 4.7e-11 42.5 32.5 1.0 1 0 0 1 1 1 1 Ribosomal protein L41 RNA_pol_Rpb6 PF01192.22 CCF50844.1 - 3.8e-18 65.1 0.1 5.3e-18 64.7 0.1 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb6 Chitin_synth_1 PF01644.17 CCF50845.1 - 9.2e-70 233.8 0.2 1.5e-69 233.2 0.2 1.3 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_1N PF08407.11 CCF50845.1 - 1.3e-24 85.9 0.0 4.1e-24 84.3 0.0 1.9 1 0 0 1 1 1 1 Chitin synthase N-terminal Chitin_synth_2 PF03142.15 CCF50845.1 - 3.3e-23 82.1 0.0 1.1e-18 67.2 0.0 2.4 2 0 0 2 2 2 2 Chitin synthase Glyco_trans_2_3 PF13632.6 CCF50845.1 - 3.9e-12 46.5 0.5 3.9e-12 46.5 0.5 2.2 2 1 0 2 2 2 1 Glycosyl transferase family group 2 CitMHS PF03600.16 CCF50845.1 - 0.043 13.0 3.2 0.083 12.1 3.2 1.5 1 0 0 1 1 1 0 Citrate transporter DUF1218 PF06749.12 CCF50845.1 - 0.9 10.1 9.4 12 6.5 0.0 3.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1218) RVT_2 PF07727.14 CCF50846.1 - 0.00026 20.7 0.2 0.00043 20.0 0.2 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) WD40 PF00400.32 CCF50848.1 - 1.4e-17 63.7 7.6 0.00052 20.8 0.8 7.5 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF50848.1 - 3e-06 27.4 0.0 20 5.5 0.0 6.3 4 3 2 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain Zn_clus PF00172.18 CCF50849.1 - 0.00014 21.9 14.5 0.0003 20.9 14.5 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PEX11 PF05648.14 CCF50850.1 - 2.6e-67 226.6 2.9 2.9e-67 226.4 2.9 1.0 1 0 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) GTP_EFTU PF00009.27 CCF50851.1 - 8.1e-67 224.5 0.2 1.1e-66 224.0 0.2 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 CCF50851.1 - 1.5e-32 111.9 0.0 4.3e-32 110.4 0.0 1.8 2 0 0 2 2 2 1 Elongation factor G, domain IV EFG_C PF00679.24 CCF50851.1 - 2.3e-21 75.6 0.0 6.5e-21 74.2 0.0 1.8 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 CCF50851.1 - 3.9e-14 52.8 0.0 1.2e-13 51.2 0.0 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_II PF14492.6 CCF50851.1 - 1.2e-13 51.0 0.0 3e-13 49.7 0.0 1.6 1 0 0 1 1 1 1 Elongation Factor G, domain II MMR_HSR1 PF01926.23 CCF50851.1 - 1.9e-05 24.7 0.1 3.8e-05 23.7 0.1 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase LRR_6 PF13516.6 CCF50852.1 - 3.2e-10 39.2 12.2 0.29 11.3 0.0 8.0 8 0 0 8 8 8 4 Leucine Rich repeat LRR_4 PF12799.7 CCF50852.1 - 2.1e-05 24.8 18.3 0.049 14.1 2.0 6.8 4 2 4 8 8 8 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 CCF50852.1 - 0.0038 17.6 7.3 7.3 7.6 0.0 6.3 7 1 1 8 8 8 1 Leucine Rich Repeat LRR_8 PF13855.6 CCF50852.1 - 0.13 12.0 11.3 0.39 10.5 0.2 5.3 5 1 0 5 5 5 0 Leucine rich repeat NOA36 PF06524.12 CCF50852.1 - 1.9 7.7 4.9 2.9 7.1 4.9 1.2 1 0 0 1 1 1 0 NOA36 protein MVL PF12151.8 CCF50854.1 - 0.059 13.2 2.2 0.13 12.2 2.2 1.5 1 0 0 1 1 1 0 Mannan-binding protein DUF1751 PF08551.10 CCF50855.1 - 4.6e-29 100.9 4.7 1.2e-28 99.6 4.7 1.7 1 0 0 1 1 1 1 Eukaryotic integral membrane protein (DUF1751) Rhomboid PF01694.22 CCF50855.1 - 0.0066 16.5 5.4 0.017 15.1 5.4 1.7 1 1 0 1 1 1 1 Rhomboid family Spb1_C PF07780.12 CCF50856.1 - 1.6e-79 266.4 22.2 1.6e-79 266.4 22.2 3.9 3 1 1 4 4 4 1 Spb1 C-terminal domain FtsJ PF01728.19 CCF50856.1 - 1.4e-55 188.2 0.1 1.6e-54 184.7 0.0 2.3 2 0 0 2 2 2 1 FtsJ-like methyltransferase DUF3381 PF11861.8 CCF50856.1 - 3.7e-47 160.2 9.5 3.7e-47 160.2 9.5 5.8 4 2 1 5 5 5 1 Domain of unknown function (DUF3381) N6_N4_Mtase PF01555.18 CCF50856.1 - 0.0037 17.0 0.2 0.77 9.4 0.0 3.1 2 1 0 2 2 2 1 DNA methylase DUF148 PF02520.17 CCF50856.1 - 0.23 11.6 6.6 0.088 12.9 2.6 2.4 2 0 0 2 2 2 0 Domain of unknown function DUF148 eIF2A PF08662.11 CCF50857.1 - 4e-40 137.8 0.0 8.3e-35 120.4 0.0 4.5 3 2 1 4 4 4 2 Eukaryotic translation initiation factor eIF2A RRM_1 PF00076.22 CCF50857.1 - 1.9e-05 24.4 0.1 5.4e-05 22.9 0.1 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) WD40 PF00400.32 CCF50857.1 - 0.013 16.3 5.4 1.5 9.8 0.1 5.2 6 0 0 6 6 6 0 WD domain, G-beta repeat AAA_32 PF13654.6 CCF50857.1 - 0.053 12.3 7.1 0.086 11.6 7.1 1.2 1 0 0 1 1 1 0 AAA domain Metal_resist PF13801.6 CCF50857.1 - 0.32 11.2 11.8 5.1 7.3 11.0 2.5 1 1 1 2 2 2 0 Heavy-metal resistance Apolipoprotein PF01442.18 CCF50857.1 - 0.33 10.8 12.3 0.67 9.8 12.3 1.5 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain ApoLp-III PF07464.11 CCF50857.1 - 0.39 10.8 3.7 0.71 10.0 3.7 1.5 1 0 0 1 1 1 0 Apolipophorin-III precursor (apoLp-III) 4HB_MCP_1 PF12729.7 CCF50857.1 - 0.42 10.1 9.0 0.79 9.2 9.0 1.4 1 0 0 1 1 1 0 Four helix bundle sensory module for signal transduction YtxH PF12732.7 CCF50857.1 - 2.8 8.5 5.1 58 4.3 5.1 2.8 1 1 0 1 1 1 0 YtxH-like protein FliT PF05400.13 CCF50857.1 - 6 7.8 14.2 3.3 8.6 7.7 2.5 1 1 1 2 2 2 0 Flagellar protein FliT Complex1_LYR PF05347.15 CCF50858.1 - 0.14 12.2 1.7 0.61 10.2 0.7 2.4 2 1 0 2 2 2 0 Complex 1 protein (LYR family) Retrotran_gag_3 PF14244.6 CCF50860.1 - 0.016 15.0 0.3 0.055 13.3 0.2 1.8 2 0 0 2 2 2 0 gag-polypeptide of LTR copia-type DUF4219 PF13961.6 CCF50860.1 - 0.041 13.6 0.1 0.12 12.1 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4219) Paramyxo_ncap PF00973.19 CCF50860.1 - 0.42 9.5 2.2 0.49 9.2 1.6 1.4 2 0 0 2 2 2 0 Paramyxovirus nucleocapsid protein Ipi1_N PF12333.8 CCF50861.1 - 7.7e-15 55.3 0.6 2.2e-13 50.7 0.2 3.2 2 0 0 2 2 2 1 Rix1 complex component involved in 60S ribosome maturation HEAT_2 PF13646.6 CCF50861.1 - 0.03 14.7 0.2 0.29 11.6 0.1 2.4 2 0 0 2 2 2 0 HEAT repeats Cnd1 PF12717.7 CCF50861.1 - 0.082 12.9 0.0 0.18 11.9 0.0 1.5 1 0 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1 DNA_pol_viral_C PF00336.18 CCF50861.1 - 0.1 12.0 0.0 0.26 10.7 0.0 1.6 1 0 0 1 1 1 0 DNA polymerase (viral) C-terminal domain Sel1 PF08238.12 CCF50862.1 - 2.1e-13 50.4 6.9 0.00051 20.6 0.1 5.9 6 0 0 6 6 6 3 Sel1 repeat MIT PF04212.18 CCF50862.1 - 0.2 11.8 1.4 7 6.8 0.0 3.7 4 0 0 4 4 4 0 MIT (microtubule interacting and transport) domain Lactamase_B_2 PF12706.7 CCF50863.1 - 5e-27 94.7 0.0 7.3e-27 94.2 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 CCF50863.1 - 3.1e-05 24.1 0.0 5e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_6 PF16661.5 CCF50863.1 - 0.015 14.8 0.0 0.026 13.9 0.0 1.3 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily domain Glyco_hydro_62 PF03664.13 CCF50866.1 - 7.2e-138 458.4 7.8 8.4e-138 458.2 7.8 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 62 Pro_isomerase PF00160.21 CCF50867.1 - 3.1e-52 177.0 0.1 1e-51 175.4 0.0 1.9 2 0 0 2 2 2 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD WD40 PF00400.32 CCF50867.1 - 0.0063 17.3 3.8 1 10.3 0.3 4.2 4 0 0 4 4 4 1 WD domain, G-beta repeat Mito_carr PF00153.27 CCF50868.1 - 2.2e-46 155.7 9.6 3.8e-17 62.0 0.1 4.7 3 1 0 3 3 3 3 Mitochondrial carrier protein CH PF00307.31 CCF50870.1 - 1.9e-47 159.9 0.0 1.5e-24 86.3 0.0 2.6 2 0 0 2 2 2 2 Calponin homology (CH) domain EFhand_Ca_insen PF08726.10 CCF50870.1 - 7.4e-21 74.0 0.0 2.3e-20 72.4 0.0 1.9 1 0 0 1 1 1 1 Ca2+ insensitive EF hand CAMSAP_CH PF11971.8 CCF50870.1 - 1.2e-10 41.1 0.0 1.5e-05 24.8 0.0 3.3 2 1 0 2 2 2 2 CAMSAP CH domain Spectrin PF00435.21 CCF50870.1 - 5.4e-06 26.8 3.9 9.6e-05 22.8 0.3 3.0 2 0 0 2 2 2 1 Spectrin repeat EF-hand_6 PF13405.6 CCF50870.1 - 7.4e-05 22.4 0.0 0.00037 20.2 0.0 2.3 2 0 0 2 2 2 1 EF-hand domain EF-hand_1 PF00036.32 CCF50870.1 - 0.0056 16.2 0.0 0.022 14.3 0.0 2.1 2 0 0 2 2 2 1 EF hand CH_2 PF06294.11 CCF50870.1 - 0.011 15.8 0.0 7.6 6.7 0.0 3.4 3 0 0 3 3 3 0 CH-like domain in sperm protein HIP1_clath_bdg PF16515.5 CCF50870.1 - 0.38 11.4 3.9 7.2 7.3 0.3 2.9 2 1 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Cofilin_ADF PF00241.20 CCF50872.1 - 1.8e-43 147.2 0.7 2e-43 147.0 0.7 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein HLH PF00010.26 CCF50873.1 - 5.9e-14 51.8 0.2 1e-13 51.0 0.2 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Prenylcys_lyase PF07156.14 CCF50874.1 - 2.5e-68 230.8 0.0 6.7e-68 229.4 0.0 1.7 1 1 0 1 1 1 1 Prenylcysteine lyase NAD_binding_8 PF13450.6 CCF50874.1 - 1.4e-09 38.0 0.1 4.4e-09 36.4 0.0 1.9 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CCF50874.1 - 2.1e-06 27.6 1.0 4.2e-05 23.3 1.0 2.1 1 1 0 1 1 1 1 FAD dependent oxidoreductase Amino_oxidase PF01593.24 CCF50874.1 - 1.7e-05 24.3 0.0 3.7e-05 23.2 0.0 1.5 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase Pyr_redox_2 PF07992.14 CCF50874.1 - 0.0044 16.3 0.0 0.032 13.5 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CCF50874.1 - 0.0059 16.6 0.0 0.014 15.4 0.0 1.6 1 0 0 1 1 1 1 FAD-NAD(P)-binding FAD_binding_3 PF01494.19 CCF50874.1 - 0.092 12.0 0.0 0.15 11.2 0.0 1.3 1 0 0 1 1 1 0 FAD binding domain Thi4 PF01946.17 CCF50874.1 - 0.1 11.8 0.0 0.18 11.0 0.0 1.3 1 0 0 1 1 1 0 Thi4 family Na_H_Exchanger PF00999.21 CCF50875.1 - 3.6e-53 180.7 38.8 5.7e-53 180.1 38.8 1.2 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family RVT_2 PF07727.14 CCF50876.1 - 1.3e-24 87.2 0.0 2e-24 86.5 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 CCF50877.1 - 5.8e-31 106.9 0.1 1e-30 106.1 0.1 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 CCF50877.1 - 7.6e-28 96.5 0.0 1.4e-27 95.6 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase PP2C PF00481.21 CCF50878.1 - 1.2e-78 264.3 0.0 1.7e-78 263.8 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C WD40 PF00400.32 CCF50879.1 - 1.5e-20 73.1 0.0 7.2e-06 26.6 0.1 6.2 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF50879.1 - 6e-07 29.7 0.0 0.056 13.7 0.1 4.8 3 2 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain Gmad1 PF10647.9 CCF50879.1 - 0.0056 16.5 0.2 0.014 15.2 0.1 1.5 1 1 0 1 1 1 1 Lipoprotein LpqB beta-propeller domain Nup160 PF11715.8 CCF50879.1 - 0.0084 14.8 0.6 0.063 11.9 0.4 1.9 2 0 0 2 2 2 1 Nucleoporin Nup120/160 Nbas_N PF15492.6 CCF50879.1 - 0.069 12.5 0.0 0.8 9.0 0.0 2.2 2 0 0 2 2 2 0 Neuroblastoma-amplified sequence, N terminal TFIIA PF03153.13 CCF50880.1 - 4.6 7.1 15.3 5.7 6.8 15.3 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Neur_chan_memb PF02932.16 CCF50880.1 - 4.7 7.2 13.8 10 6.1 13.8 1.6 1 1 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Intimin_C PF07979.11 CCF50880.1 - 5.8 7.4 11.5 0.11 12.9 2.9 2.2 1 1 1 2 2 2 0 Intimin C-type lectin domain PH_10 PF15411.6 CCF50881.1 - 3.2e-26 92.0 0.0 5.7e-26 91.2 0.0 1.4 1 0 0 1 1 1 1 Pleckstrin homology domain zf-RING_UBOX PF13445.6 CCF50881.1 - 0.0005 20.0 0.9 0.0011 18.9 0.9 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 CCF50881.1 - 0.00077 19.4 0.6 0.0023 17.8 0.7 1.8 1 1 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 CCF50881.1 - 0.00091 19.5 1.7 0.0017 18.7 0.5 2.0 2 0 0 2 2 2 1 Ring finger domain VWA_3 PF13768.6 CCF50881.1 - 0.0071 16.3 0.0 0.13 12.2 0.0 2.5 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA PF00092.28 CCF50881.1 - 0.029 14.6 0.0 0.096 12.9 0.0 2.0 2 1 0 2 2 2 0 von Willebrand factor type A domain FliH PF02108.16 CCF50881.1 - 0.06 13.4 1.4 0.78 9.8 0.5 2.6 3 0 0 3 3 3 0 Flagellar assembly protein FliH AAA_lid_6 PF17866.1 CCF50881.1 - 0.099 12.8 0.2 0.29 11.3 0.2 1.7 1 0 0 1 1 1 0 AAA lid domain zf-C3HC4_2 PF13923.6 CCF50881.1 - 0.13 12.2 0.8 0.31 10.9 0.8 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 CCF50881.1 - 0.13 12.1 2.4 0.29 10.9 2.4 1.7 1 0 0 1 1 1 0 RING-like zinc finger zf-C3HC4 PF00097.25 CCF50881.1 - 0.14 12.1 0.4 0.31 10.9 0.4 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Chromo PF00385.24 CCF50883.1 - 1.3e-09 37.8 3.6 1.1e-07 31.7 0.9 2.4 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain ASD1 PF08688.10 CCF50883.1 - 0.0058 17.1 0.0 0.0083 16.6 0.0 1.3 1 0 0 1 1 1 1 Apx/Shroom domain ASD1 Ribonuc_red_lgC PF02867.15 CCF50884.1 - 8.7e-186 618.5 0.0 1.1e-185 618.1 0.0 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, barrel domain Ribonuc_red_lgN PF00317.21 CCF50884.1 - 5.2e-25 87.3 0.0 1.7e-24 85.6 0.0 2.0 1 0 0 1 1 1 1 Ribonucleotide reductase, all-alpha domain ATP-cone PF03477.16 CCF50884.1 - 1.2e-17 64.3 0.2 4e-17 62.5 0.2 2.0 1 0 0 1 1 1 1 ATP cone domain Na_Ca_ex PF01699.24 CCF50885.1 - 1.3e-21 77.1 28.1 4.5e-12 46.2 13.7 2.7 2 0 0 2 2 2 2 Sodium/calcium exchanger protein YccF PF03733.13 CCF50885.1 - 1.2e-14 54.7 6.8 1.2e-14 54.7 6.8 3.2 2 0 0 2 2 2 1 Inner membrane component domain Otopetrin PF03189.13 CCF50885.1 - 0.063 12.1 0.6 0.16 10.7 0.6 1.6 1 0 0 1 1 1 0 Otopetrin Alb1 PF09135.11 CCF50886.1 - 0.014 16.3 7.3 0.017 16.0 7.3 1.2 1 0 0 1 1 1 0 Alb1 Ufd2P_core PF10408.9 CCF50887.1 - 6.7e-200 665.8 0.0 8e-200 665.6 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin elongating factor core U-box PF04564.15 CCF50887.1 - 2.3e-27 95.0 0.5 5.7e-27 93.7 0.5 1.7 1 0 0 1 1 1 1 U-box domain BCNT PF07572.12 CCF50888.1 - 5.8e-20 71.1 0.4 1.5e-19 69.8 0.4 1.7 1 0 0 1 1 1 1 Bucentaur or craniofacial development DUF4505 PF14956.6 CCF50891.1 - 2.3e-27 95.9 0.0 1.5e-12 47.6 0.1 2.5 2 1 0 2 2 2 2 Domain of unknown function (DUF4505) Ribosomal_S8 PF00410.19 CCF50892.1 - 2e-12 47.1 0.0 2.2e-11 43.8 0.0 1.9 1 1 0 1 1 1 1 Ribosomal protein S8 Yos1 PF08571.10 CCF50893.1 - 2.4e-31 107.8 0.9 3e-31 107.5 0.9 1.1 1 0 0 1 1 1 1 Yos1-like DnaJ_C PF01556.18 CCF50894.1 - 1e-34 119.8 0.1 1.3e-34 119.4 0.1 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 CCF50894.1 - 2.2e-25 88.5 3.0 3.1e-25 88.1 3.0 1.2 1 0 0 1 1 1 1 DnaJ domain RPT PF13446.6 CCF50894.1 - 0.039 13.9 0.1 0.062 13.2 0.1 1.2 1 0 0 1 1 1 0 A repeated domain in UCH-protein PsbW PF07123.12 CCF50895.1 - 1.6 8.8 4.6 0.63 10.1 0.7 2.4 2 0 0 2 2 2 0 Photosystem II reaction centre W protein (PsbW) UDG PF03167.19 CCF50896.1 - 1.7e-16 60.5 0.0 6e-16 58.8 0.0 1.9 2 0 0 2 2 2 1 Uracil DNA glycosylase superfamily UPF0564 PF10595.9 CCF50896.1 - 0.56 9.2 5.3 0.89 8.5 5.3 1.2 1 0 0 1 1 1 0 Uncharacterised protein family UPF0564 Arrestin_N PF00339.29 CCF50897.1 - 1.3e-05 25.3 0.1 2.9e-05 24.1 0.1 1.6 1 1 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain LDB19 PF13002.7 CCF50897.1 - 0.002 17.8 0.0 0.033 13.9 0.0 2.2 2 0 0 2 2 2 1 Arrestin_N terminal like Aldedh PF00171.22 CCF50898.1 - 2.8e-156 520.7 0.0 3.3e-156 520.4 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family NDUFA12 PF05071.16 CCF50899.1 - 9.6e-31 106.5 2.8 1.2e-30 106.1 2.8 1.1 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase subunit NDUFA12 MIS13 PF08202.11 CCF50900.1 - 2e-19 70.0 6.2 2e-19 70.0 6.2 2.9 2 2 0 2 2 2 1 Mis12-Mtw1 protein family UPF0547 PF10571.9 CCF50902.1 - 0.055 13.6 0.8 0.14 12.3 0.8 1.8 1 0 0 1 1 1 0 Uncharacterised protein family UPF0547 zf-ribbon_3 PF13248.6 CCF50902.1 - 1.3 8.5 4.7 0.25 10.8 0.7 1.9 2 0 0 2 2 2 0 zinc-ribbon domain SDA1 PF05285.12 CCF50902.1 - 5.9 6.2 13.2 0.46 9.9 4.4 2.1 2 0 0 2 2 2 0 SDA1 YhfH PF14149.6 CCF50902.1 - 9.5 6.3 7.9 0.18 11.8 0.8 1.8 2 0 0 2 2 2 0 YhfH-like protein Flavokinase PF01687.17 CCF50903.1 - 7.6e-32 109.9 0.0 1.9e-31 108.6 0.0 1.6 1 1 0 1 1 1 1 Riboflavin kinase Thr_synth_N PF14821.6 CCF50904.1 - 4.7e-24 84.4 0.0 1.2e-23 83.1 0.0 1.8 1 0 0 1 1 1 1 Threonine synthase N terminus PALP PF00291.25 CCF50904.1 - 1.6e-11 44.2 0.0 1e-10 41.5 0.0 1.9 2 0 0 2 2 2 1 Pyridoxal-phosphate dependent enzyme G0-G1_switch_2 PF15103.6 CCF50905.1 - 0.065 13.7 0.1 0.065 13.7 0.1 3.9 4 0 0 4 4 4 0 G0/G1 switch protein 2 CAP PF00188.26 CCF50906.1 - 1e-13 52.2 1.9 1e-13 52.2 1.9 2.1 2 0 0 2 2 2 1 Cysteine-rich secretory protein family XPG_I PF00867.18 CCF50907.1 - 2.1e-08 34.4 0.0 2.2e-07 31.2 0.0 2.3 2 0 0 2 2 2 1 XPG I-region XPG_N PF00752.17 CCF50907.1 - 2.8e-06 27.7 0.0 5.8e-06 26.7 0.0 1.6 1 0 0 1 1 1 1 XPG N-terminal domain 5_3_exonuc PF01367.20 CCF50907.1 - 0.00046 20.7 0.0 0.002 18.7 0.0 2.0 2 0 0 2 2 2 1 5'-3' exonuclease, C-terminal SAM fold Phe_tRNA-synt_N PF02912.18 CCF50907.1 - 0.002 18.0 0.6 0.0041 17.0 0.6 1.5 1 0 0 1 1 1 1 Aminoacyl tRNA synthetase class II, N-terminal domain HHH_5 PF14520.6 CCF50907.1 - 0.022 15.3 0.0 0.073 13.7 0.0 1.9 1 0 0 1 1 1 0 Helix-hairpin-helix domain V-ATPase_G PF03179.15 CCF50909.1 - 6.1e-36 123.1 17.9 8.8e-36 122.6 17.9 1.2 1 0 0 1 1 1 1 Vacuolar (H+)-ATPase G subunit ATP-synt_B PF00430.18 CCF50909.1 - 0.0056 16.8 12.2 0.0056 16.8 12.2 2.4 1 1 2 3 3 3 2 ATP synthase B/B' CF(0) Ntox34 PF15606.6 CCF50909.1 - 0.1 12.7 1.5 0.22 11.7 0.4 1.9 2 0 0 2 2 2 0 Bacterial toxin 34 Prominin PF05478.11 CCF50909.1 - 0.56 8.1 10.1 0.63 7.9 10.1 1.0 1 0 0 1 1 1 0 Prominin ATP-synt_F6 PF05511.11 CCF50909.1 - 0.6 10.6 6.8 0.58 10.6 3.8 2.3 1 1 1 2 2 2 0 Mitochondrial ATP synthase coupling factor 6 Seryl_tRNA_N PF02403.22 CCF50909.1 - 0.67 10.2 22.0 0.19 12.0 16.8 2.3 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain DUF3552 PF12072.8 CCF50909.1 - 0.86 9.0 27.1 1.1 8.6 27.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) HEPN_AbiU2 PF18734.1 CCF50909.1 - 1.3 8.4 10.3 0.81 9.2 3.8 2.0 1 1 1 2 2 2 0 AbiU2 V-ATPase_G_2 PF16999.5 CCF50909.1 - 1.8 9.0 17.3 0.73 10.3 13.3 2.2 1 1 1 2 2 2 0 Vacuolar (H+)-ATPase G subunit DUF4375 PF14300.6 CCF50909.1 - 1.9 8.8 10.2 1.7 8.9 3.4 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4375) SAM_Exu PF18609.1 CCF50909.1 - 2.9 8.1 9.1 0.28 11.3 0.5 2.7 2 1 1 3 3 3 0 Exuperantia SAM-like domain DUF948 PF06103.11 CCF50909.1 - 3.1 8.1 6.5 3.1 8.1 4.4 2.1 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) ZYG-11_interact PF05884.12 CCF50909.1 - 3.7 6.9 4.5 6 6.2 4.5 1.4 1 1 0 1 1 1 0 Interactor of ZYG-11 ArAE_2_N PF10337.9 CCF50909.1 - 6.7 5.6 6.7 7.6 5.5 6.7 1.1 1 0 0 1 1 1 0 Putative ER transporter, 6TM, N-terminal DUF4407 PF14362.6 CCF50909.1 - 7.1 5.9 20.4 8.4 5.7 20.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Exonuc_VII_L PF02601.15 CCF50909.1 - 7.9 5.9 16.5 9.2 5.7 16.5 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit Symplekin_C PF12295.8 CCF50910.1 - 3.6e-61 206.5 0.4 1.3e-60 204.7 0.1 2.1 2 0 0 2 2 2 1 Symplekin tight junction protein C terminal DUF3453 PF11935.8 CCF50910.1 - 2.1e-51 174.8 1.6 4.7e-51 173.6 1.6 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3453) FbpA PF05833.11 CCF50910.1 - 0.0011 17.9 0.4 0.0019 17.0 0.4 1.3 1 0 0 1 1 1 1 Fibronectin-binding protein A N-terminus (FbpA) Mito_fiss_reg PF05308.11 CCF50910.1 - 2 8.4 14.3 0.2 11.7 6.1 2.5 2 0 0 2 2 2 0 Mitochondrial fission regulator OPT PF03169.15 CCF50911.1 - 3.9e-171 570.8 53.8 4.4e-171 570.6 53.8 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein His_Phos_2 PF00328.22 CCF50912.1 - 3.4e-43 148.5 0.0 4.4e-43 148.1 0.0 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) Sec7 PF01369.20 CCF50913.1 - 1.7e-69 233.2 0.1 3.7e-69 232.1 0.1 1.6 1 0 0 1 1 1 1 Sec7 domain Sec7_N PF12783.7 CCF50913.1 - 6.9e-47 159.3 4.8 6.9e-47 159.3 4.8 4.6 5 1 0 5 5 5 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DUF1981 PF09324.10 CCF50913.1 - 2.2e-32 110.7 10.4 1.7e-31 107.9 0.0 5.8 6 0 0 6 6 6 1 Domain of unknown function (DUF1981) DCB PF16213.5 CCF50913.1 - 3.6e-22 78.9 1.4 3.6e-22 78.9 1.4 3.5 4 1 1 5 5 5 1 Dimerisation and cyclophilin-binding domain of Mon2 Imm52 PF15579.6 CCF50913.1 - 0.11 12.3 0.1 17 5.3 0.0 3.4 3 0 0 3 3 3 0 Immunity protein 52 Mob1_phocein PF03637.17 CCF50914.1 - 6.8e-78 260.5 0.1 8e-78 260.3 0.1 1.0 1 0 0 1 1 1 1 Mob1/phocein family Glyco_tranf_2_3 PF13641.6 CCF50916.1 - 2.3e-22 80.0 0.0 3.2e-22 79.5 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.6 CCF50916.1 - 6.6e-18 65.3 6.3 6.6e-18 65.3 6.3 2.1 2 1 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_transf_21 PF13506.6 CCF50916.1 - 1.6e-09 37.4 0.0 2.4e-09 36.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 21 Glycos_transf_2 PF00535.26 CCF50916.1 - 1.1e-05 25.3 0.0 2.1e-05 24.4 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 2 Acyl_transf_3 PF01757.22 CCF50917.1 - 1.8e-14 53.6 33.0 4.5e-14 52.3 33.0 1.7 1 0 0 1 1 1 1 Acyltransferase family Glyco_hydro_16 PF00722.21 CCF50917.1 - 0.00033 20.2 0.0 0.00057 19.4 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 Sel1 PF08238.12 CCF50918.1 - 1.7e-17 63.4 35.2 0.015 16.0 0.1 10.6 12 0 0 12 12 12 6 Sel1 repeat DUF4834 PF16118.5 CCF50918.1 - 0.0027 18.6 0.3 3.1 8.8 0.1 2.9 2 0 0 2 2 2 2 Domain of unknown function (DUF4834) TPR_19 PF14559.6 CCF50918.1 - 0.011 16.2 0.8 0.36 11.4 0.0 4.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.6 CCF50918.1 - 0.11 12.6 10.4 0.32 11.1 0.0 6.3 8 0 0 8 8 8 0 Tetratricopeptide repeat TPR_8 PF13181.6 CCF50918.1 - 0.15 12.3 0.0 0.15 12.3 0.0 4.5 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_2 PF07719.17 CCF50918.1 - 1.1 9.6 0.0 1.1 9.6 0.0 7.2 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_1 PF00515.28 CCF50918.1 - 1.4 8.9 0.0 1.4 8.9 0.0 5.6 7 0 0 7 7 7 0 Tetratricopeptide repeat DUF2681 PF10883.8 CCF50918.1 - 3.4 8.1 13.1 0.33 11.4 3.3 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF2681) DRIM PF07539.12 CCF50919.1 - 2.1e-171 571.4 0.6 2.1e-171 571.4 0.6 4.8 5 1 0 5 5 5 2 Down-regulated in metastasis DUF3385 PF11865.8 CCF50919.1 - 0.0069 16.3 2.8 0.78 9.6 0.2 3.4 3 0 0 3 3 3 2 Domain of unknown function (DUF3385) TetR_C_18 PF17923.1 CCF50919.1 - 0.076 13.5 2.2 0.38 11.3 0.1 3.4 3 0 0 3 3 3 0 Tetracyclin repressor-like, C-terminal domain Sec7_N PF12783.7 CCF50919.1 - 0.46 10.4 6.2 0.95 9.3 0.0 4.0 4 0 0 4 4 4 0 Guanine nucleotide exchange factor in Golgi transport N-terminal RRN3 PF05327.11 CCF50919.1 - 1.5 7.3 17.4 2.7 6.4 2.6 3.8 3 0 0 3 3 3 0 RNA polymerase I specific transcription initiation factor RRN3 Glyco_hydro_30 PF02055.16 CCF50920.1 - 1.2e-16 60.7 0.4 2.1e-16 59.9 0.4 1.5 1 1 0 1 1 1 1 Glycosyl hydrolase family 30 TIM-barrel domain Glyco_hydro_59 PF02057.15 CCF50920.1 - 7.3e-11 41.8 0.4 1.1e-08 34.7 0.1 2.2 2 0 0 2 2 2 2 Glycosyl hydrolase family 59 AMP-binding PF00501.28 CCF50922.1 - 3.1e-88 296.2 0.0 4.2e-88 295.8 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 CCF50922.1 - 5.7e-12 46.5 0.2 1.8e-11 44.8 0.2 2.0 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Kri1 PF05178.12 CCF50925.1 - 1.5e-28 99.3 8.8 1.5e-28 99.3 8.8 5.2 6 0 0 6 6 6 1 KRI1-like family Kri1_C PF12936.7 CCF50925.1 - 2.6e-24 85.2 0.1 2.6e-24 85.2 0.1 4.4 4 1 1 5 5 5 1 KRI1-like family C-terminal Alpha_GJ PF03229.13 CCF50925.1 - 3.1 8.4 6.8 3.5 8.2 0.2 3.0 2 0 0 2 2 2 0 Alphavirus glycoprotein J p450 PF00067.22 CCF50926.1 - 3.3e-21 75.6 0.0 6.1e-21 74.7 0.0 1.5 1 1 0 1 1 1 1 Cytochrome P450 GTP1_OBG PF01018.22 CCF50927.1 - 3.3e-41 140.5 0.2 3.6e-29 101.3 0.4 2.4 2 0 0 2 2 2 2 GTP1/OBG MMR_HSR1 PF01926.23 CCF50927.1 - 1.1e-19 70.6 0.0 2.3e-19 69.6 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase RRM_1 PF00076.22 CCF50927.1 - 1.7e-05 24.6 0.0 0.00058 19.6 0.0 2.6 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FeoB_N PF02421.18 CCF50927.1 - 7.3e-05 22.3 0.1 0.00028 20.5 0.0 2.0 2 0 0 2 2 2 1 Ferrous iron transport protein B GTP_EFTU PF00009.27 CCF50927.1 - 0.00011 21.8 0.1 0.0015 18.1 0.1 2.2 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 CCF50927.1 - 0.0075 15.6 0.0 0.015 14.6 0.0 1.4 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MeaB PF03308.16 CCF50927.1 - 0.019 13.9 1.7 1.7 7.5 0.0 2.3 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Arf PF00025.21 CCF50927.1 - 0.024 14.1 0.0 1.1 8.6 0.0 2.3 2 0 0 2 2 2 0 ADP-ribosylation factor family ABC_tran PF00005.27 CCF50927.1 - 0.051 14.1 0.0 0.15 12.6 0.0 1.8 1 0 0 1 1 1 0 ABC transporter MnmE_helical PF12631.7 CCF50927.1 - 0.086 13.0 0.7 0.18 12.0 0.7 1.4 1 0 0 1 1 1 0 MnmE helical domain cobW PF02492.19 CCF50927.1 - 0.22 11.1 0.1 3.4 7.2 0.0 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Cellulase PF00150.18 CCF50928.1 - 4e-13 49.4 2.0 4.4e-13 49.3 0.1 1.8 2 0 0 2 2 2 1 Cellulase (glycosyl hydrolase family 5) RCC1 PF00415.18 CCF50929.1 - 2.9e-46 155.9 1.4 1.9e-12 47.6 0.0 6.1 6 0 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 CCF50929.1 - 1.3e-24 85.4 16.3 5.7e-07 29.2 0.4 6.2 6 0 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat PHD PF00628.29 CCF50929.1 - 1.8e-10 40.5 4.9 4.3e-10 39.3 4.9 1.7 1 0 0 1 1 1 1 PHD-finger zf-UDP PF14569.6 CCF50929.1 - 0.0011 19.1 4.3 0.0014 18.7 2.4 2.2 3 0 0 3 3 3 1 Zinc-binding RING-finger PHD_4 PF16866.5 CCF50929.1 - 0.0047 17.0 7.8 0.011 15.8 7.8 1.7 1 0 0 1 1 1 1 PHD-finger Zf_RING PF16744.5 CCF50929.1 - 0.063 13.4 2.3 0.15 12.2 2.3 1.6 1 1 0 1 1 1 0 KIAA1045 RING finger SUKH-3 PF14433.6 CCF50929.1 - 0.077 13.5 0.1 2.3 8.7 0.0 3.1 4 0 0 4 4 4 0 SUKH-3 immunity protein OrfB_Zn_ribbon PF07282.11 CCF50929.1 - 1.5 8.8 3.3 8.2 6.4 0.5 2.5 2 0 0 2 2 2 0 Putative transposase DNA-binding domain PknG_rubred PF16919.5 CCF50929.1 - 1.6 8.9 5.7 14 5.9 0.1 2.5 1 1 1 2 2 2 0 Protein kinase G rubredoxin domain Glyco_tranf_2_3 PF13641.6 CCF50930.1 - 7.3e-10 39.1 0.0 1.6e-09 38.0 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 CCF50930.1 - 4.7e-05 23.3 0.0 9.2e-05 22.3 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 2 TauD PF02668.16 CCF50932.1 - 5.7e-26 91.9 0.1 8.1e-26 91.4 0.1 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family BofC_C PF08955.10 CCF50932.1 - 0.13 12.4 0.0 0.43 10.7 0.0 1.9 1 0 0 1 1 1 0 BofC C-terminal domain eIF2A PF08662.11 CCF50933.1 - 1.1e-82 276.7 0.4 1.1e-81 273.3 0.0 2.4 2 1 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A WD40 PF00400.32 CCF50933.1 - 0.00016 22.4 2.9 9.5 7.3 0.1 4.8 5 0 0 5 5 5 2 WD domain, G-beta repeat Proteasome_A_N PF10584.9 CCF50933.1 - 0.49 10.1 3.5 14 5.4 0.0 3.6 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature IATP PF04568.12 CCF50933.1 - 1.8 9.0 9.8 0.33 11.4 2.6 2.8 2 0 0 2 2 2 0 Mitochondrial ATPase inhibitor, IATP AAA_9 PF12781.7 CCF50934.1 - 2.4e-74 249.2 0.2 2.4e-74 249.2 0.2 3.2 4 0 0 4 4 4 1 ATP-binding dynein motor region MT PF12777.7 CCF50934.1 - 3.9e-47 160.9 6.2 3.9e-47 160.9 6.2 1.6 2 0 0 2 2 2 1 Microtubule-binding stalk of dynein motor Dynein_C PF18199.1 CCF50934.1 - 2.1e-38 132.3 0.0 6.4e-38 130.7 0.0 1.8 1 0 0 1 1 1 1 Dynein heavy chain C-terminal domain AAA_lid_11 PF18198.1 CCF50934.1 - 5.6e-34 117.3 0.0 1.3e-33 116.1 0.0 1.6 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain Dynein_heavy PF03028.15 CCF50934.1 - 2.1e-26 92.3 0.0 3.7e-25 88.3 0.0 2.8 2 0 0 2 2 2 1 Dynein heavy chain region D6 P-loop domain AAA_8 PF12780.7 CCF50934.1 - 0.00011 21.6 0.0 0.00029 20.2 0.0 1.7 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 DUF4250 PF14056.6 CCF50934.1 - 0.077 13.0 2.0 6.6 6.8 0.1 3.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4250) Spc7 PF08317.11 CCF50934.1 - 0.12 11.3 32.5 0.013 14.4 11.3 3.2 3 0 0 3 3 3 0 Spc7 kinetochore protein DUF2644 PF10841.8 CCF50934.1 - 0.16 12.2 0.1 0.38 11.0 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2644) APG6_N PF17675.1 CCF50934.1 - 4.2 7.9 30.8 0.41 11.2 2.3 3.7 3 0 0 3 3 3 0 Apg6 coiled-coil region ZapB PF06005.12 CCF50934.1 - 4.7 7.7 29.9 0.85 10.1 2.9 4.9 4 1 0 4 4 4 0 Cell division protein ZapB DUF948 PF06103.11 CCF50934.1 - 7.2 6.9 15.2 3.9 7.8 0.4 4.1 3 2 0 3 3 3 0 Bacterial protein of unknown function (DUF948) HAUS6_N PF14661.6 CCF50934.1 - 7.7 6.0 20.4 0.27 10.8 0.8 3.1 3 0 0 3 3 3 0 HAUS augmin-like complex subunit 6 N-terminus DUF3328 PF11807.8 CCF50935.1 - 0.06 13.1 0.2 0.091 12.5 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3328) Gal-bind_lectin PF00337.22 CCF50935.1 - 0.076 12.5 0.0 0.087 12.4 0.0 1.2 1 0 0 1 1 1 0 Galactoside-binding lectin Gp45_2 PF17470.2 CCF50935.1 - 0.15 12.1 0.0 0.33 10.9 0.0 1.6 1 0 0 1 1 1 0 Phage gene product 45.2 Prenyltrans PF00432.21 CCF50936.1 - 4.2e-36 122.4 12.9 1.8e-13 49.9 0.4 6.6 5 2 0 5 5 5 5 Prenyltransferase and squalene oxidase repeat SQHop_cyclase_N PF13249.6 CCF50936.1 - 0.078 12.1 0.0 10 5.1 0.0 2.9 2 1 1 3 3 3 0 Squalene-hopene cyclase N-terminal domain SQS_PSY PF00494.19 CCF50937.1 - 6.6e-32 111.1 0.0 1.4e-31 110.0 0.0 1.5 2 0 0 2 2 2 1 Squalene/phytoene synthase YwiC PF14256.6 CCF50937.1 - 0.044 14.1 0.1 0.11 12.9 0.1 1.6 1 0 0 1 1 1 0 YwiC-like protein PrmA PF06325.13 CCF50938.1 - 3.1e-12 46.5 0.0 5.1e-12 45.8 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.6 CCF50938.1 - 1.1e-10 42.1 0.0 3.4e-10 40.5 0.0 1.9 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF50938.1 - 2.4e-10 40.4 0.0 6.6e-10 39.0 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF50938.1 - 3.9e-07 30.6 0.0 4.2e-06 27.3 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 CCF50938.1 - 3e-06 26.9 0.1 5.6e-06 26.0 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_23 PF13489.6 CCF50938.1 - 1.3e-05 25.1 0.0 2.6e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.7 CCF50938.1 - 5.4e-05 23.2 0.0 9.6e-05 22.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 CCF50938.1 - 6.8e-05 22.3 0.0 0.00015 21.2 0.0 1.5 2 0 0 2 2 2 1 Mycolic acid cyclopropane synthetase Methyltransf_24 PF13578.6 CCF50938.1 - 0.00017 22.6 0.1 0.00083 20.4 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF50938.1 - 0.00019 22.1 0.0 0.00059 20.5 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_16 PF10294.9 CCF50938.1 - 0.00024 20.9 0.0 0.00037 20.3 0.0 1.3 1 0 0 1 1 1 1 Lysine methyltransferase Cons_hypoth95 PF03602.15 CCF50938.1 - 0.00096 18.8 0.1 0.0042 16.7 0.0 2.0 2 0 0 2 2 2 1 Conserved hypothetical protein 95 PCMT PF01135.19 CCF50938.1 - 0.0012 18.6 0.0 0.002 17.9 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_9 PF08003.11 CCF50938.1 - 0.0084 15.1 0.0 0.019 13.9 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) Met_10 PF02475.16 CCF50938.1 - 0.028 14.2 0.3 0.051 13.3 0.0 1.5 2 0 0 2 2 2 0 Met-10+ like-protein PRMT5 PF05185.16 CCF50938.1 - 0.028 14.3 0.3 0.07 13.0 0.0 1.7 2 0 0 2 2 2 0 PRMT5 arginine-N-methyltransferase UPF0020 PF01170.18 CCF50938.1 - 0.03 14.0 0.1 0.072 12.8 0.1 1.6 1 1 0 1 1 1 0 Putative RNA methylase family UPF0020 Methyltransf_32 PF13679.6 CCF50938.1 - 0.063 13.3 0.0 0.16 11.9 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain Peptidase_M28 PF04389.17 CCF50939.1 - 1.6e-32 112.8 0.0 2.6e-32 112.1 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M28 DUF2070 PF09843.9 CCF50939.1 - 0.21 9.8 11.7 0.08 11.2 8.7 1.8 1 1 1 2 2 2 0 Predicted membrane protein (DUF2070) APG9 PF04109.16 CCF50940.1 - 2.6e-203 676.4 2.2 3e-203 676.2 2.2 1.0 1 0 0 1 1 1 1 Autophagy protein Apg9 SNF5 PF04855.12 CCF50941.1 - 7.1e-65 219.1 1.4 7.1e-65 219.1 1.4 3.5 3 0 0 3 3 3 1 SNF5 / SMARCB1 / INI1 GATA PF00320.27 CCF50941.1 - 0.00091 18.8 1.4 0.0019 17.8 1.4 1.6 1 0 0 1 1 1 1 GATA zinc finger CPSase_L_D2 PF02786.17 CCF50942.1 - 8.2e-76 254.2 0.0 1.4e-75 253.5 0.0 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.22 CCF50942.1 - 4.1e-42 143.2 0.0 1.2e-41 141.7 0.0 1.8 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 CCF50942.1 - 5.9e-33 113.2 0.0 5.9e-32 110.0 0.0 2.4 1 1 0 1 1 1 1 Biotin carboxylase C-terminal domain Dala_Dala_lig_C PF07478.13 CCF50942.1 - 2.1e-10 40.5 0.0 4.9e-10 39.3 0.0 1.5 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus Biotin_lipoyl PF00364.22 CCF50942.1 - 6.3e-10 38.8 1.2 1.4e-09 37.7 1.2 1.6 1 0 0 1 1 1 1 Biotin-requiring enzyme ATP-grasp PF02222.22 CCF50942.1 - 3.2e-08 33.3 0.0 1.1e-07 31.6 0.0 1.8 2 0 0 2 2 2 1 ATP-grasp domain GARS_A PF01071.19 CCF50942.1 - 0.0001 22.1 0.0 0.00026 20.8 0.0 1.7 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain Biotin_lipoyl_2 PF13533.6 CCF50942.1 - 0.00011 21.9 0.0 0.00031 20.5 0.0 1.7 1 0 0 1 1 1 1 Biotin-lipoyl like ATP-grasp_3 PF02655.14 CCF50942.1 - 0.00058 20.0 0.0 0.0013 18.8 0.0 1.6 1 0 0 1 1 1 1 ATP-grasp domain ATPgrasp_ST PF14397.6 CCF50942.1 - 0.0082 15.4 0.0 0.028 13.7 0.0 1.8 2 0 0 2 2 2 1 Sugar-transfer associated ATP-grasp RimK PF08443.11 CCF50942.1 - 0.015 14.9 0.0 0.09 12.4 0.0 2.1 1 1 0 1 1 1 0 RimK-like ATP-grasp domain DUF3182 PF11379.8 CCF50942.1 - 0.05 12.6 0.0 0.083 11.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3182) EMP24_GP25L PF01105.24 CCF50943.1 - 2.2e-42 145.0 0.0 2.9e-42 144.7 0.0 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Integrase_H2C2 PF17921.1 CCF50944.1 - 2.5e-15 56.3 2.1 4.6e-15 55.5 2.1 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 CCF50944.1 - 4e-15 56.1 0.0 6.8e-15 55.3 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain CHCH PF06747.13 CCF50947.1 - 2.1e-05 24.5 3.6 3e-05 24.0 3.6 1.3 1 0 0 1 1 1 1 CHCH domain MTCP1 PF08991.10 CCF50947.1 - 2.7e-05 24.3 2.5 5e-05 23.4 2.5 1.4 1 0 0 1 1 1 1 Mature-T-Cell Proliferation I type NDUF_B7 PF05676.13 CCF50947.1 - 0.00018 21.2 2.6 0.00026 20.6 2.6 1.2 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) Pet191_N PF10203.9 CCF50947.1 - 0.0061 16.8 2.9 0.0092 16.3 2.9 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein PET191 UPF0203 PF05254.12 CCF50947.1 - 0.013 15.7 2.1 0.028 14.6 2.1 1.7 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0203) DUF3326 PF11805.8 CCF50947.1 - 0.044 12.6 0.0 0.047 12.5 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3326) TAP_C PF03943.13 CCF50947.1 - 0.08 12.6 0.1 0.12 12.0 0.1 1.3 1 0 0 1 1 1 0 TAP C-terminal domain NuA4 PF09340.10 CCF50948.1 - 1.3e-22 79.4 0.2 3.3e-22 78.1 0.2 1.7 1 0 0 1 1 1 1 Histone acetyltransferase subunit NuA4 Rubella_E2 PF05749.11 CCF50948.1 - 8.2 5.8 6.5 13 5.2 6.5 1.2 1 0 0 1 1 1 0 Rubella membrane glycoprotein E2 AvrPphF-ORF-2 PF09143.10 CCF50949.1 - 0.077 12.9 0.1 0.17 11.8 0.1 1.6 2 0 0 2 2 2 0 AvrPphF-ORF-2 ER_lumen_recept PF00810.18 CCF50952.1 - 2.3e-55 187.5 6.8 2.3e-55 187.5 6.8 1.4 2 0 0 2 2 2 1 ER lumen protein retaining receptor PQ-loop PF04193.14 CCF50952.1 - 2.8e-05 23.8 4.6 0.48 10.2 0.0 4.0 3 1 1 4 4 4 2 PQ loop repeat DAGK_cat PF00781.24 CCF50953.1 - 3.4e-15 55.8 0.0 5.9e-15 55.0 0.0 1.4 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain SMC_N PF02463.19 CCF50954.1 - 7.9e-69 231.4 0.0 1.4e-68 230.7 0.0 1.6 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 CCF50954.1 - 2.4e-28 98.8 0.0 6.7e-28 97.4 0.0 1.8 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_15 PF13175.6 CCF50954.1 - 1.3e-19 71.2 10.9 5.3e-13 49.4 0.0 3.4 2 2 1 3 3 3 2 AAA ATPase domain AAA_23 PF13476.6 CCF50954.1 - 2e-18 67.6 1.7 2e-18 67.6 1.7 6.6 2 2 3 5 5 5 1 AAA domain AAA_21 PF13304.6 CCF50954.1 - 1.1e-15 58.3 15.9 4.3e-10 39.9 1.3 3.9 3 1 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 CCF50954.1 - 0.018 14.8 0.0 0.039 13.7 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Phg_2220_C PF09524.10 CCF50954.1 - 0.065 13.3 1.9 16 5.6 0.1 3.2 2 0 0 2 2 2 0 Conserved phage C-terminus (Phg_2220_C) FtsK_SpoIIIE PF01580.18 CCF50954.1 - 0.099 12.0 4.0 0.16 11.3 0.0 3.3 3 0 0 3 3 3 0 FtsK/SpoIIIE family FA PF08736.11 CCF50954.1 - 1.7 8.8 5.6 1 9.5 0.6 3.1 2 0 0 2 2 2 0 FERM adjacent (FA) RRM_1 PF00076.22 CCF50955.1 - 5.6e-07 29.3 0.3 1.4e-06 28.0 0.0 1.9 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FHA PF00498.26 CCF50956.1 - 2.7e-15 56.4 0.0 7.1e-15 55.1 0.0 1.8 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 CCF50956.1 - 0.00038 20.7 0.0 0.0076 16.5 0.0 2.8 3 0 0 3 3 2 1 Inner membrane component of T3SS, cytoplasmic domain DUF1664 PF07889.12 CCF50956.1 - 0.0029 17.6 13.0 0.017 15.2 0.8 3.0 4 0 0 4 4 3 2 Protein of unknown function (DUF1664) PilJ PF13675.6 CCF50956.1 - 0.012 15.7 2.6 0.012 15.7 2.6 3.6 2 1 1 3 3 3 0 Type IV pili methyl-accepting chemotaxis transducer N-term Laminin_II PF06009.12 CCF50956.1 - 0.2 11.7 15.7 0.87 9.6 1.4 2.7 2 0 0 2 2 2 0 Laminin Domain II DUF812 PF05667.11 CCF50956.1 - 0.34 9.7 17.8 0.14 11.1 1.6 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF812) ATG16 PF08614.11 CCF50956.1 - 0.36 11.0 26.5 0.71 10.1 6.8 3.5 3 0 0 3 3 3 0 Autophagy protein 16 (ATG16) Tweety PF04906.13 CCF50956.1 - 0.4 9.3 3.8 0.29 9.7 0.8 1.9 2 0 0 2 2 2 0 Tweety TRAF_BIRC3_bd PF16673.5 CCF50956.1 - 0.66 9.8 9.6 13 5.7 0.3 3.7 3 0 0 3 3 3 0 TNF receptor-associated factor BIRC3 binding domain HemX PF04375.14 CCF50956.1 - 1.1 8.5 20.4 0.38 10.0 3.3 2.3 2 0 0 2 2 2 0 HemX, putative uroporphyrinogen-III C-methyltransferase FAM76 PF16046.5 CCF50956.1 - 1.6 8.0 10.1 3.7 6.8 0.8 2.3 2 0 0 2 2 2 0 FAM76 protein LMBR1 PF04791.16 CCF50956.1 - 1.9 7.3 7.4 0.098 11.5 0.6 1.8 2 0 0 2 2 2 0 LMBR1-like membrane protein Spc29 PF17082.5 CCF50956.1 - 2.1 8.1 9.7 8.9 6.1 3.8 2.3 2 0 0 2 2 2 0 Spindle Pole Component 29 Macoilin PF09726.9 CCF50956.1 - 2.3 6.7 14.3 5.8 5.4 14.3 1.6 1 0 0 1 1 1 0 Macoilin family EzrA PF06160.12 CCF50956.1 - 2.8 6.0 11.5 2.7 6.1 0.3 2.1 2 0 0 2 2 2 0 Septation ring formation regulator, EzrA Fibin PF15819.5 CCF50956.1 - 4.8 6.9 8.0 0.6 9.8 0.5 2.7 2 1 1 3 3 3 0 Fin bud initiation factor homologue NPV_P10 PF05531.12 CCF50956.1 - 5.7 7.5 9.8 78 3.8 1.3 4.0 3 1 1 4 4 4 0 Nucleopolyhedrovirus P10 protein UPF0449 PF15136.6 CCF50956.1 - 6 7.4 13.4 5 7.7 1.1 3.4 3 0 0 3 3 3 0 Uncharacterised protein family UPF0449 DUF4047 PF13256.6 CCF50956.1 - 8.8 6.5 10.2 0.093 12.9 1.2 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF4047) DUF1179 PF06678.11 CCF50957.1 - 0.057 13.4 0.7 0.45 10.5 0.7 2.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1179) BRO1 PF03097.18 CCF50958.1 - 2.2e-17 63.0 0.0 2.7e-08 33.1 0.0 2.2 2 0 0 2 2 2 2 BRO1-like domain MscS_porin PF12795.7 CCF50959.1 - 0.00017 21.2 28.6 0.00017 21.2 28.6 7.9 2 1 7 9 9 9 3 Mechanosensitive ion channel porin domain CENP-F_leu_zip PF10473.9 CCF50959.1 - 0.00079 19.5 144.8 0.01 15.8 18.6 8.1 4 1 4 8 8 8 4 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ATG16 PF08614.11 CCF50959.1 - 0.0024 18.1 23.0 0.0024 18.1 23.0 8.9 1 1 5 7 7 7 2 Autophagy protein 16 (ATG16) FlxA PF14282.6 CCF50959.1 - 0.0062 16.5 4.6 0.0062 16.5 4.6 10.5 5 4 5 11 11 11 4 FlxA-like protein Pox_A_type_inc PF04508.12 CCF50959.1 - 0.15 12.0 3.1 27 4.9 0.0 5.3 4 0 0 4 4 4 0 Viral A-type inclusion protein repeat Leu_zip PF15294.6 CCF50959.1 - 0.4 10.2 0.0 0.4 10.2 0.0 7.3 2 1 4 7 7 7 0 Leucine zipper NAPRTase_N PF17767.1 CCF50959.1 - 0.84 10.0 5.1 7.4 7.0 0.0 4.1 3 1 0 3 3 3 0 Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain Hat1_N PF10394.9 CCF50959.1 - 3.2 8.0 7.9 0.46 10.7 0.6 2.7 2 0 0 2 2 2 0 Histone acetyl transferase HAT1 N-terminus PhoLip_ATPase_C PF16212.5 CCF50960.1 - 2.3e-71 240.4 22.5 2.3e-71 240.4 22.5 1.6 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 CCF50960.1 - 5.8e-27 93.2 1.7 1.5e-26 91.8 1.7 1.8 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Cation_ATPase PF13246.6 CCF50960.1 - 3.9e-12 46.1 0.0 1.3e-11 44.4 0.0 1.8 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 CCF50960.1 - 9.4e-11 42.4 1.7 1.1e-06 29.1 0.8 3.3 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 CCF50960.1 - 0.00021 20.9 0.0 0.00081 19.0 0.0 2.0 1 1 0 1 1 1 1 E1-E2 ATPase Hydrolase_3 PF08282.12 CCF50960.1 - 0.0057 16.4 0.0 0.03 14.1 0.0 2.0 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Pinin_SDK_memA PF04696.13 CCF50961.1 - 2e-13 50.5 9.8 7.3e-13 48.7 2.0 2.6 2 1 1 3 3 3 2 pinin/SDK/memA/ protein conserved region Cue1_U7BR PF18499.1 CCF50961.1 - 0.027 14.5 0.0 0.06 13.4 0.0 1.6 1 0 0 1 1 1 0 Ubc7p-binding region of Cue1 FliD_C PF07195.12 CCF50961.1 - 0.14 11.5 1.2 0.38 10.1 0.7 1.9 1 1 1 2 2 2 0 Flagellar hook-associated protein 2 C-terminus TPR_MLP1_2 PF07926.12 CCF50961.1 - 3.6 7.7 9.3 3.9 7.5 0.8 2.2 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein Jnk-SapK_ap_N PF09744.9 CCF50961.1 - 4.1 7.6 8.5 2.5 8.3 1.5 2.1 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 vWA-TerF-like PF10138.9 CCF50962.1 - 1.2e-08 35.4 0.0 2e-08 34.6 0.0 1.3 1 0 0 1 1 1 1 vWA found in TerF C terminus YqzL PF14006.6 CCF50962.1 - 0.00078 19.8 1.0 0.0018 18.6 1.0 1.6 1 0 0 1 1 1 1 YqzL-like protein VWA PF00092.28 CCF50962.1 - 0.0081 16.4 0.1 0.044 14.0 0.1 2.0 1 1 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 CCF50962.1 - 0.054 14.1 0.3 0.26 12.0 0.1 2.4 2 1 0 2 2 1 0 von Willebrand factor type A domain RIC3 PF15361.6 CCF50962.1 - 0.092 13.1 0.1 0.31 11.4 0.0 1.9 2 0 0 2 2 2 0 Resistance to inhibitors of cholinesterase homologue 3 COX14 PF14880.6 CCF50962.1 - 0.11 12.4 3.0 0.28 11.1 3.0 1.7 1 0 0 1 1 1 0 Cytochrome oxidase c assembly Miga PF10265.9 CCF50962.1 - 0.14 11.1 0.5 0.23 10.4 0.5 1.2 1 0 0 1 1 1 0 Mitoguardin NCE101 PF11654.8 CCF50962.1 - 0.16 11.7 0.0 0.55 10.0 0.0 1.8 2 0 0 2 2 2 0 Non-classical export protein 1 DUF2967 PF11179.8 CCF50962.1 - 0.42 8.7 12.7 0.68 8.0 12.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2967) SR-25 PF10500.9 CCF50962.1 - 0.99 9.0 9.8 6.3 6.3 4.3 2.2 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein SpoIIIAH PF12685.7 CCF50962.1 - 1.6 8.5 5.0 0.31 10.8 1.3 1.6 2 0 0 2 2 2 0 SpoIIIAH-like protein SUIM_assoc PF16619.5 CCF50962.1 - 2 8.6 15.5 0.03 14.4 6.7 2.6 3 0 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 Spt20 PF12090.8 CCF50962.1 - 2.7 7.5 10.7 4.9 6.7 10.7 1.3 1 0 0 1 1 1 0 Spt20 family HEAT_EZ PF13513.6 CCF50964.1 - 8.8e-34 115.5 21.5 1.4e-13 51.0 0.0 10.5 10 2 2 12 12 11 6 HEAT-like repeat HEAT PF02985.22 CCF50964.1 - 4.9e-20 69.9 12.6 0.0017 18.4 0.0 9.1 8 0 0 8 8 7 4 HEAT repeat HEAT_2 PF13646.6 CCF50964.1 - 3.2e-15 56.3 0.1 4.8e-05 23.7 0.0 6.9 5 3 2 7 7 7 2 HEAT repeats Vac14_Fab1_bd PF12755.7 CCF50964.1 - 3.4e-10 40.4 0.0 0.00019 22.0 0.2 3.9 2 2 1 3 3 3 3 Vacuolar 14 Fab1-binding region Cnd1 PF12717.7 CCF50964.1 - 2.4e-06 27.7 0.0 0.17 12.0 0.1 3.9 4 0 0 4 4 4 2 non-SMC mitotic condensation complex subunit 1 IBN_N PF03810.19 CCF50964.1 - 2.5e-06 27.3 0.1 1.6e-05 24.7 0.0 2.4 2 0 0 2 2 2 1 Importin-beta N-terminal domain MMS19_C PF12460.8 CCF50964.1 - 3.2e-05 23.2 1.5 0.071 12.2 0.0 3.8 4 0 0 4 4 4 2 RNAPII transcription regulator C-terminal DUF3437 PF11919.8 CCF50964.1 - 0.00012 21.9 0.0 0.023 14.6 0.0 3.3 3 0 0 3 3 3 1 Domain of unknown function (DUF3437) Arm PF00514.23 CCF50964.1 - 0.00097 19.1 2.6 9.3 6.5 0.0 5.8 7 0 0 7 7 5 0 Armadillo/beta-catenin-like repeat DUF3385 PF11865.8 CCF50964.1 - 0.0026 17.7 0.2 5.6 6.8 0.1 4.8 3 3 1 4 4 4 1 Domain of unknown function (DUF3385) Cnd3 PF12719.7 CCF50964.1 - 0.004 16.4 0.2 0.19 10.9 0.1 3.1 2 1 1 3 3 3 1 Nuclear condensing complex subunits, C-term domain Ecm29 PF13001.7 CCF50964.1 - 0.0069 15.1 0.0 1.5 7.4 0.1 3.7 3 1 0 3 3 3 1 Proteasome stabiliser Adaptin_N PF01602.20 CCF50964.1 - 0.0076 14.9 0.1 0.12 10.9 0.1 2.6 3 0 0 3 3 3 1 Adaptin N terminal region UNC45-central PF11701.8 CCF50964.1 - 0.018 15.0 0.0 0.13 12.2 0.0 2.4 3 0 0 3 3 3 0 Myosin-binding striated muscle assembly central RTP1_C1 PF10363.9 CCF50964.1 - 0.032 14.4 0.0 0.4 10.9 0.0 2.8 2 0 0 2 2 2 0 Required for nuclear transport of RNA pol II C-terminus 1 TIP120 PF08623.10 CCF50964.1 - 0.069 12.9 0.0 4.7 6.9 0.1 3.1 3 0 0 3 3 3 0 TATA-binding protein interacting (TIP20) Homeodomain PF00046.29 CCF50964.1 - 0.18 11.7 0.0 0.42 10.5 0.0 1.6 1 0 0 1 1 1 0 Homeodomain Sigma70_ner PF04546.13 CCF50964.1 - 0.38 10.6 2.2 35 4.2 0.0 2.3 2 0 0 2 2 2 0 Sigma-70, non-essential region CENP-B_dimeris PF09026.10 CCF50964.1 - 0.49 10.8 9.4 1.2 9.6 9.4 1.6 1 0 0 1 1 1 0 Centromere protein B dimerisation domain PBP1_TM PF14812.6 CCF50964.1 - 1.3 9.4 6.2 2.9 8.3 6.2 1.5 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal RRM_1 PF00076.22 CCF50967.1 - 2.1e-30 104.3 0.1 2.3e-07 30.6 0.0 4.3 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 CCF50967.1 - 7.7e-09 35.3 0.0 0.09 12.7 0.0 3.9 4 0 0 4 4 4 3 Occluded RNA-recognition motif RRM_5 PF13893.6 CCF50967.1 - 0.0016 18.0 0.0 0.74 9.4 0.0 3.2 2 2 2 4 4 4 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CCF50967.1 - 0.02 15.0 0.0 52 4.1 0.0 3.7 3 0 0 3 3 3 0 RNA recognition motif Mito_carr PF00153.27 CCF50968.1 - 2.3e-64 213.4 2.8 8.9e-21 73.6 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Peptidase_S8 PF00082.22 CCF50969.1 - 2.8e-33 115.4 7.3 5.3e-33 114.6 7.3 1.4 1 0 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 CCF50969.1 - 1.9e-10 41.3 0.1 3.4e-10 40.4 0.1 1.4 1 0 0 1 1 1 1 Peptidase inhibitor I9 Cpn60_TCP1 PF00118.24 CCF50970.1 - 2.9e-153 511.1 3.1 3.2e-153 510.9 3.1 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family PH PF00169.29 CCF50971.1 - 0.00081 19.9 0.1 0.0051 17.3 0.0 2.3 2 1 0 2 2 2 1 PH domain SLD3 PF08639.10 CCF50972.1 - 4.2e-14 52.2 0.4 9.6e-14 51.0 0.4 1.5 1 1 0 1 1 1 1 DNA replication regulator SLD3 Glyco_hydro_31 PF01055.26 CCF50973.1 - 1.7e-127 426.3 1.4 3.4e-127 425.3 1.4 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.6 CCF50973.1 - 1.2e-20 73.5 0.2 1.7e-19 69.9 0.0 2.5 2 0 0 2 2 2 1 Galactose mutarotase-like DUF5110 PF17137.4 CCF50973.1 - 2.7e-06 27.6 0.0 7.4e-06 26.1 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF5110) TP_methylase PF00590.20 CCF50974.1 - 5.2e-20 72.3 0.0 1.6e-19 70.7 0.0 1.8 1 1 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases Sad1_UNC PF07738.13 CCF50975.1 - 8.8e-25 87.2 0.0 1.5e-24 86.5 0.0 1.4 1 0 0 1 1 1 1 Sad1 / UNC-like C-terminal EVC2_like PF12297.8 CCF50975.1 - 0.57 8.8 8.1 0.91 8.1 8.1 1.2 1 0 0 1 1 1 0 Ellis van Creveld protein 2 like protein PSI PF01437.25 CCF50979.1 - 0.011 16.2 0.9 0.024 15.2 0.9 1.5 1 0 0 1 1 1 0 Plexin repeat Phage_glycop_gL PF11108.8 CCF50980.1 - 0.1 12.7 0.1 0.14 12.2 0.1 1.2 1 0 0 1 1 1 0 Viral glycoprotein L RVT_2 PF07727.14 CCF50982.1 - 1.2e-38 133.2 0.2 5.9e-24 85.0 0.1 2.3 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) gag_pre-integrs PF13976.6 CCF50983.1 - 0.0029 17.4 0.1 0.0057 16.5 0.1 1.6 1 0 0 1 1 1 1 GAG-pre-integrase domain DUF2828 PF11443.8 CCF50983.1 - 0.04 12.0 0.1 0.046 11.8 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) DUF4219 PF13961.6 CCF50984.1 - 0.018 14.7 0.2 0.51 10.1 0.0 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4219) RPN5_C PF18098.1 CCF50984.1 - 0.092 12.9 1.2 10 6.3 0.1 3.5 3 0 0 3 3 3 0 26S proteasome regulatory subunit RPN5 C-terminal domain PBP1_TM PF14812.6 CCF50984.1 - 0.14 12.6 3.0 1.4 9.3 0.2 2.3 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal RVT_2 PF07727.14 CCF50985.1 - 5.7e-11 42.5 0.0 7.2e-11 42.2 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) MFS_1 PF07690.16 CCF50987.1 - 8e-16 57.9 48.1 2.3e-14 53.1 47.7 2.4 1 1 0 1 1 1 1 Major Facilitator Superfamily Myb_Cef PF11831.8 CCF50988.1 - 4.7e-57 193.3 8.3 4.7e-57 193.3 8.3 3.4 4 0 0 4 4 4 1 pre-mRNA splicing factor component Myb_DNA-binding PF00249.31 CCF50988.1 - 4.9e-21 74.7 6.1 3.8e-11 43.0 1.3 2.5 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 CCF50988.1 - 1.1e-17 64.0 5.2 2.4e-12 46.9 3.8 2.9 1 1 1 2 2 2 2 Myb-like DNA-binding domain MSA-2c PF12238.8 CCF50988.1 - 0.075 13.0 2.9 0.16 12.0 2.9 1.5 1 0 0 1 1 1 0 Merozoite surface antigen 2c Senescence PF06911.12 CCF50988.1 - 0.086 13.1 0.2 0.24 11.7 0.2 1.8 1 0 0 1 1 1 0 Senescence-associated protein bZIP_1 PF00170.21 CCF50989.1 - 1.7e-06 28.0 1.1 1.7e-06 28.0 1.1 2.0 3 0 0 3 3 3 1 bZIP transcription factor bZIP_2 PF07716.15 CCF50989.1 - 0.08 13.0 2.9 0.21 11.7 2.9 1.7 1 0 0 1 1 1 0 Basic region leucine zipper Uso1_p115_head PF04869.14 CCF50990.1 - 3e-53 181.0 0.1 4.5e-48 164.0 0.0 4.9 4 1 0 4 4 4 2 Uso1 / p115 like vesicle tethering protein, head region Uso1_p115_C PF04871.13 CCF50990.1 - 1.4e-05 25.5 32.8 1.4e-05 25.5 32.8 6.9 5 1 2 7 7 7 1 Uso1 / p115 like vesicle tethering protein, C terminal region Arm_vescicular PF18770.1 CCF50990.1 - 0.00048 20.0 1.4 0.00075 19.4 0.1 2.0 2 0 0 2 2 2 1 Armadillo tether-repeat of vescicular transport factor Golgin_A5 PF09787.9 CCF50990.1 - 0.0041 16.6 19.7 0.0041 16.6 19.7 4.4 2 1 2 4 4 4 1 Golgin subfamily A member 5 CorA PF01544.18 CCF50990.1 - 0.014 14.7 12.1 0.012 14.9 2.4 2.6 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein Atx10homo_assoc PF09759.9 CCF50990.1 - 0.34 10.9 0.0 0.34 10.9 0.0 6.5 9 0 0 9 9 9 0 Spinocerebellar ataxia type 10 protein domain Pox_A_type_inc PF04508.12 CCF50990.1 - 0.49 10.3 9.3 1.4 8.9 0.8 4.2 4 0 0 4 4 4 0 Viral A-type inclusion protein repeat DASH_Hsk3 PF08227.11 CCF50990.1 - 9 6.8 24.2 0.74 10.2 2.9 4.9 5 1 0 5 5 5 0 DASH complex subunit Hsk3 like Spo12 PF05032.12 CCF50991.1 - 3e-10 39.8 3.6 1.5e-09 37.6 0.4 2.7 2 0 0 2 2 2 2 Spo12 family POB3_N PF17292.2 CCF50992.1 - 1.5e-28 99.1 0.0 4.2e-25 88.0 0.0 2.4 2 0 0 2 2 2 2 POB3-like N-terminal PH domain SSrecog PF03531.14 CCF50992.1 - 8.5e-24 83.3 0.0 3.1e-23 81.5 0.0 2.0 2 0 0 2 2 2 1 Structure-specific recognition protein (SSRP1) Rtt106 PF08512.12 CCF50992.1 - 5.1e-23 81.3 0.0 1.7e-22 79.7 0.0 1.9 2 0 0 2 2 2 1 Histone chaperone Rttp106-like DUF1899 PF08953.11 CCF50993.1 - 7.2e-32 109.1 0.4 2.7e-31 107.2 0.3 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF1899) WD40_4 PF16300.5 CCF50993.1 - 3.7e-18 65.1 0.4 4e-16 58.6 0.1 2.6 2 0 0 2 2 2 1 Type of WD40 repeat WD40 PF00400.32 CCF50993.1 - 9.4e-09 35.8 6.4 0.09 13.7 0.0 5.4 5 0 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF50993.1 - 2.3e-06 27.8 0.4 1.3 9.4 0.0 5.3 5 1 1 6 6 6 1 Anaphase-promoting complex subunit 4 WD40 domain FAM76 PF16046.5 CCF50993.1 - 0.0005 19.5 3.4 0.00068 19.1 3.4 1.2 1 0 0 1 1 1 1 FAM76 protein UPF0242 PF06785.11 CCF50993.1 - 0.0032 17.6 4.3 0.0054 16.9 4.3 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0242) N-terminus PspA_IM30 PF04012.12 CCF50993.1 - 0.0035 17.0 4.6 0.0054 16.3 4.6 1.2 1 0 0 1 1 1 1 PspA/IM30 family ZapB PF06005.12 CCF50993.1 - 0.0041 17.5 9.5 0.0074 16.7 9.5 1.4 1 0 0 1 1 1 1 Cell division protein ZapB CEND1 PF15677.5 CCF50993.1 - 0.021 15.4 4.6 0.037 14.6 4.6 1.3 1 0 0 1 1 1 0 Cell cycle exit and neuronal differentiation protein 1 Phage_GP20 PF06810.11 CCF50993.1 - 0.037 13.8 6.4 0.072 12.9 6.4 1.4 1 0 0 1 1 1 0 Phage minor structural protein GP20 Geminin PF07412.12 CCF50993.1 - 0.04 13.7 4.7 0.077 12.7 4.7 1.4 1 0 0 1 1 1 0 Geminin APC_N_CC PF16689.5 CCF50993.1 - 0.047 13.8 3.4 0.1 12.7 3.4 1.5 1 0 0 1 1 1 0 Coiled-coil N-terminus of APC, dimerisation domain Menin PF05053.13 CCF50993.1 - 0.05 12.0 8.4 0.069 11.5 8.4 1.1 1 0 0 1 1 1 0 Menin YabA PF06156.13 CCF50993.1 - 0.083 13.5 5.6 0.15 12.7 5.6 1.4 1 0 0 1 1 1 0 Initiation control protein YabA TSC22 PF01166.18 CCF50993.1 - 0.14 12.5 4.7 0.36 11.2 4.7 1.6 1 0 0 1 1 1 0 TSC-22/dip/bun family MPS2 PF17060.5 CCF50993.1 - 0.16 11.2 1.5 0.24 10.6 1.5 1.2 1 0 0 1 1 1 0 Monopolar spindle protein 2 Ax_dynein_light PF10211.9 CCF50993.1 - 0.2 11.6 5.2 0.3 11.0 5.2 1.2 1 0 0 1 1 1 0 Axonemal dynein light chain DUF16 PF01519.16 CCF50993.1 - 0.23 12.0 5.0 0.41 11.2 5.0 1.4 1 0 0 1 1 1 0 Protein of unknown function DUF16 Nup54_57_C PF18570.1 CCF50993.1 - 0.69 9.6 5.5 0.46 10.1 1.1 2.3 1 1 1 2 2 2 0 NUP57/Nup54 C-terminal domain DUF4337 PF14235.6 CCF50993.1 - 3 7.9 4.3 10 6.2 2.6 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4337) DUF4407 PF14362.6 CCF50993.1 - 4 6.7 5.5 5.9 6.2 5.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Dmrt1 PF12374.8 CCF50993.1 - 8.1 7.0 7.1 25 5.4 3.9 2.7 2 0 0 2 2 2 0 Double-sex mab3 related transcription factor 1 RNase_T PF00929.24 CCF50994.1 - 2.9e-25 89.7 0.0 3.6e-25 89.4 0.0 1.1 1 0 0 1 1 1 1 Exonuclease CRAL_TRIO PF00650.20 CCF50995.1 - 6.6e-28 97.4 0.1 1e-27 96.8 0.1 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.6 CCF50995.1 - 5.9e-09 36.2 0.0 1.2e-08 35.2 0.0 1.5 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain CRAL_TRIO_N PF03765.15 CCF50995.1 - 8e-07 29.2 0.1 2.2e-06 27.7 0.1 1.7 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain Mucin PF01456.17 CCF50995.1 - 0.0026 17.7 18.2 0.0056 16.7 18.2 1.5 1 0 0 1 1 1 1 Mucin-like glycoprotein DUF3535 PF12054.8 CCF50995.1 - 0.15 11.3 2.8 0.25 10.6 2.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3535) SSP160 PF06933.11 CCF50995.1 - 0.17 10.1 19.8 0.27 9.4 19.8 1.3 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Dicty_REP PF05086.12 CCF50995.1 - 0.6 8.0 6.0 0.8 7.6 6.0 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DUF3439 PF11921.8 CCF50995.1 - 5.2 7.1 17.5 10 6.1 17.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) FSA_C PF10479.9 CCF50995.1 - 5.8 4.9 9.8 8.3 4.4 9.8 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Pantoate_transf PF02548.15 CCF50996.1 - 1.4e-83 280.2 0.2 1.9e-79 266.7 0.1 2.3 2 1 0 2 2 2 2 Ketopantoate hydroxymethyltransferase PEP_mutase PF13714.6 CCF50996.1 - 0.00013 21.5 0.7 0.00081 18.9 0.0 2.3 2 1 0 2 2 2 1 Phosphoenolpyruvate phosphomutase BTV_NS2 PF04514.12 CCF50996.1 - 0.11 11.3 0.0 0.17 10.7 0.0 1.2 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 Zn_clus PF00172.18 CCF50997.1 - 7.9e-06 25.9 9.6 1.4e-05 25.1 9.6 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain RRM_1 PF00076.22 CCF50998.1 - 3.3e-39 132.6 0.0 3.8e-21 74.7 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CCF50998.1 - 3e-07 30.5 0.0 0.00029 20.9 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif RRM_3 PF08777.11 CCF50998.1 - 0.034 14.2 5.3 2.3 8.3 0.0 3.2 2 1 1 3 3 3 0 RNA binding motif RRM_5 PF13893.6 CCF50998.1 - 0.046 13.3 0.0 0.27 10.8 0.0 2.1 1 1 1 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Macoilin PF09726.9 CCF50998.1 - 0.066 11.8 24.4 0.078 11.5 24.4 1.1 1 0 0 1 1 1 0 Macoilin family NUDIX PF00293.28 CCF50999.1 - 2.7e-15 56.6 0.0 4.7e-15 55.8 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain NUDIX-like PF09296.11 CCF50999.1 - 1.1e-08 35.7 0.0 2.1e-08 34.7 0.0 1.5 1 1 0 1 1 1 1 NADH pyrophosphatase-like rudimentary NUDIX domain 7TM_GPCR_Str PF10326.9 CCF50999.1 - 0.14 11.5 0.0 2.1 7.6 0.0 2.1 2 0 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Str EMG1 PF03587.14 CCF51000.1 - 7.7e-78 260.6 0.0 1.1e-77 260.1 0.0 1.2 1 0 0 1 1 1 1 EMG1/NEP1 methyltransferase DUF3498 PF12004.8 CCF51000.1 - 0.062 12.5 0.0 0.062 12.5 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3498) Ank_4 PF13637.6 CCF51001.1 - 3.2e-19 69.0 3.1 7.2e-11 42.4 0.2 4.9 3 2 2 5 5 5 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 CCF51001.1 - 4e-18 65.8 0.0 1.3e-08 35.3 0.0 2.9 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 CCF51001.1 - 3.2e-14 52.6 0.0 4.4e-05 23.7 0.0 3.9 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.6 CCF51001.1 - 2.7e-12 45.7 0.2 0.00076 19.7 0.0 4.4 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.6 CCF51001.1 - 3.1e-12 46.4 1.0 3.3e-06 27.2 0.0 3.1 3 0 0 3 3 3 2 Ankyrin repeats (many copies) KilA-N PF04383.13 CCF51001.1 - 7.4e-06 25.8 0.1 0.0001 22.1 0.1 2.3 1 1 0 1 1 1 1 KilA-N domain UPF0300 PF08594.10 CCF51001.1 - 0.064 12.6 0.0 0.13 11.6 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0300) DUF2408 PF10303.9 CCF51001.1 - 0.52 10.9 4.5 3.1 8.4 0.1 2.6 2 1 0 3 3 3 0 Protein of unknown function (DUF2408) DUF4472 PF14739.6 CCF51001.1 - 1.1 10.0 5.2 22 5.8 2.9 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4472) DHR10 PF18595.1 CCF51001.1 - 1.8 8.6 9.7 2 8.5 6.3 2.2 2 0 0 2 2 2 0 Designed helical repeat protein 10 domain APG6_N PF17675.1 CCF51001.1 - 5.1 7.6 7.2 6.9 7.2 3.6 2.2 2 0 0 2 2 2 0 Apg6 coiled-coil region MRP-S34 PF16053.5 CCF51002.1 - 3.2e-08 33.3 0.3 0.00048 19.8 0.1 2.2 1 1 1 2 2 2 2 Mitochondrial 28S ribosomal protein S34 MoCF_biosynth PF00994.24 CCF51004.1 - 1e-54 184.1 0.2 1.2e-26 93.1 0.0 2.5 2 0 0 2 2 2 2 Probable molybdopterin binding domain MoeA_N PF03453.17 CCF51004.1 - 9.4e-35 119.7 0.3 1.5e-34 119.1 0.3 1.3 1 0 0 1 1 1 1 MoeA N-terminal region (domain I and II) MoeA_C PF03454.15 CCF51004.1 - 9.8e-16 57.7 0.5 3.3e-15 56.0 0.0 2.1 2 0 0 2 2 2 1 MoeA C-terminal region (domain IV) SH3_9 PF14604.6 CCF51005.1 - 2.1e-08 33.9 0.0 4.1e-08 32.9 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 CCF51005.1 - 3.1e-07 29.9 0.0 5.5e-07 29.1 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 CCF51005.1 - 0.00011 21.9 0.0 0.00019 21.0 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain TFIIA PF03153.13 CCF51005.1 - 0.65 9.9 14.3 0.83 9.6 14.3 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Hamartin PF04388.12 CCF51005.1 - 0.97 8.0 22.8 1.6 7.3 22.8 1.3 1 0 0 1 1 1 0 Hamartin protein ACBP PF00887.19 CCF51006.1 - 6.8e-25 87.1 0.0 1.3e-24 86.2 0.0 1.5 1 0 0 1 1 1 1 Acyl CoA binding protein Peroxin-3 PF04882.12 CCF51007.1 - 1.7e-140 469.1 0.8 1.8e-139 465.8 0.8 2.1 1 1 0 1 1 1 1 Peroxin-3 PAM2 PF07145.15 CCF51007.1 - 0.0063 16.1 0.6 0.02 14.5 0.6 1.9 1 0 0 1 1 1 1 Ataxin-2 C-terminal region TIP49 PF06068.13 CCF51008.1 - 1.7e-162 540.6 0.2 3.5e-162 539.5 0.2 1.5 1 1 0 1 1 1 1 TIP49 P-loop domain TIP49_C PF17856.1 CCF51008.1 - 4.9e-21 74.6 0.1 1.2e-20 73.4 0.1 1.7 1 0 0 1 1 1 1 TIP49 AAA-lid domain AAA PF00004.29 CCF51008.1 - 1.4e-10 41.8 0.8 2.2e-06 28.1 0.0 2.7 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 CCF51008.1 - 7e-09 35.6 0.0 1.2e-05 25.1 0.0 2.5 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 CCF51008.1 - 2.4e-06 27.9 0.1 0.016 15.4 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.6 CCF51008.1 - 0.00045 20.6 1.8 0.1 13.0 0.2 2.5 2 1 0 2 2 2 2 AAA domain AAA_5 PF07728.14 CCF51008.1 - 0.00056 19.9 0.1 0.19 11.7 0.0 2.5 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 CCF51008.1 - 0.0021 18.5 0.7 0.014 15.8 0.1 2.5 2 1 0 2 2 2 1 AAA ATPase domain AAA_28 PF13521.6 CCF51008.1 - 0.0025 18.1 0.1 0.0053 17.0 0.1 1.5 1 0 0 1 1 1 1 AAA domain Sigma54_activat PF00158.26 CCF51008.1 - 0.0063 16.2 0.1 2.9 7.6 0.0 2.5 2 0 0 2 2 2 2 Sigma-54 interaction domain Mg_chelatase PF01078.21 CCF51008.1 - 0.0095 15.3 0.1 0.58 9.5 0.1 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI Zeta_toxin PF06414.12 CCF51008.1 - 0.013 14.8 0.3 0.028 13.7 0.3 1.5 1 0 0 1 1 1 0 Zeta toxin AAA_25 PF13481.6 CCF51008.1 - 0.015 14.9 0.0 0.059 12.9 0.0 1.9 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 CCF51008.1 - 0.037 13.8 0.1 0.089 12.5 0.1 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein DnaB_C PF03796.15 CCF51008.1 - 0.043 13.1 0.0 0.076 12.3 0.0 1.4 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain UBA_2 PF08587.11 CCF51008.1 - 0.059 13.5 0.0 0.16 12.1 0.0 1.7 1 0 0 1 1 1 0 Ubiquitin associated domain (UBA) DUF2075 PF09848.9 CCF51008.1 - 0.11 11.7 0.0 0.16 11.2 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) TsaE PF02367.17 CCF51008.1 - 0.15 12.1 0.1 0.31 11.0 0.1 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE rve PF00665.26 CCF51010.1 - 3.1e-17 62.9 0.0 7.2e-17 61.7 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain Chromo PF00385.24 CCF51010.1 - 2.3e-13 49.8 0.0 4.8e-13 48.8 0.0 1.6 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Integrase_H2C2 PF17921.1 CCF51010.1 - 0.049 13.7 0.2 0.11 12.6 0.2 1.7 1 0 0 1 1 1 0 Integrase zinc binding domain Ceramidase PF05875.12 CCF51012.1 - 1.1e-80 270.8 4.4 1.3e-80 270.6 4.4 1.0 1 0 0 1 1 1 1 Ceramidase Leader_Trp PF08255.11 CCF51012.1 - 0.36 10.9 4.8 5.8 7.2 1.7 3.0 2 0 0 2 2 2 0 Trp-operon Leader Peptide Glyco_hydro_10 PF00331.20 CCF51013.1 - 5.4e-52 176.9 0.2 6.5e-52 176.7 0.2 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 10 TrkH PF02386.16 CCF51015.1 - 5.5e-102 341.8 9.6 7.6e-99 331.4 6.3 2.1 2 0 0 2 2 2 2 Cation transport protein NEMP PF10225.9 CCF51015.1 - 0.0094 15.7 0.1 0.0094 15.7 0.1 1.7 2 0 0 2 2 2 1 NEMP family DUF1455 PF07306.11 CCF51015.1 - 0.37 10.7 3.5 0.2 11.6 0.7 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1455) GAGA_bind PF06217.12 CCF51016.1 - 0.0092 16.3 2.0 0.0092 16.3 2.0 1.2 1 0 0 1 1 1 1 GAGA binding protein-like family RNA_polI_A34 PF08208.11 CCF51016.1 - 0.061 13.4 19.4 0.096 12.8 19.4 1.4 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 SR-25 PF10500.9 CCF51016.1 - 0.088 12.4 24.4 0.048 13.3 11.3 2.2 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein DUF3348 PF11828.8 CCF51016.1 - 0.11 12.2 0.1 0.11 12.2 0.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3348) TSGP1 PF07771.11 CCF51016.1 - 2.5 8.3 12.3 5.8 7.1 12.3 1.7 1 0 0 1 1 1 0 Tick salivary peptide group 1 Med19 PF10278.9 CCF51016.1 - 6.5 6.7 17.8 9.4 6.1 16.8 1.7 2 0 0 2 2 2 0 Mediator of RNA pol II transcription subunit 19 UPF0016 PF01169.19 CCF51017.1 - 2.8e-42 142.9 23.2 4.1e-21 75.1 8.7 2.3 2 0 0 2 2 2 2 Uncharacterized protein family UPF0016 Mntp PF02659.15 CCF51017.1 - 0.0016 18.2 6.8 0.0037 17.0 0.1 2.3 2 0 0 2 2 2 1 Putative manganese efflux pump Bac_export_2 PF01312.19 CCF51017.1 - 0.016 14.4 0.3 0.016 14.4 0.3 1.8 2 0 0 2 2 2 0 FlhB HrpN YscU SpaS Family Na_Ca_ex PF01699.24 CCF51017.1 - 0.33 10.9 11.7 1.2 9.1 1.7 2.3 2 0 0 2 2 2 0 Sodium/calcium exchanger protein TerC PF03741.16 CCF51017.1 - 0.4 10.3 10.7 0.32 10.7 3.3 2.3 2 0 0 2 2 2 0 Integral membrane protein TerC family Sacchrp_dh_NADP PF03435.18 CCF51018.1 - 5.1e-15 55.9 0.0 9.4e-15 55.0 0.0 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Semialdhyde_dh PF01118.24 CCF51018.1 - 0.0004 20.8 0.0 0.0033 17.8 0.0 2.3 1 1 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain NAD_binding_10 PF13460.6 CCF51018.1 - 0.0029 17.5 0.0 0.02 14.8 0.0 2.1 2 0 0 2 2 2 1 NAD(P)H-binding DapB_N PF01113.20 CCF51018.1 - 0.01 15.9 0.0 0.018 15.1 0.0 1.4 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus NmrA PF05368.13 CCF51018.1 - 0.037 13.6 0.0 0.06 12.9 0.0 1.4 1 0 0 1 1 1 0 NmrA-like family Epimerase PF01370.21 CCF51018.1 - 0.083 12.3 0.0 0.13 11.7 0.0 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Peptidase_M4_C PF02868.15 CCF51019.1 - 0.083 12.7 0.0 0.24 11.3 0.0 1.7 1 0 0 1 1 1 0 Thermolysin metallopeptidase, alpha-helical domain Frataxin_Cyay PF01491.16 CCF51020.1 - 1.3e-39 134.6 0.0 1.8e-39 134.2 0.0 1.2 1 0 0 1 1 1 1 Frataxin-like domain Unstab_antitox PF09720.10 CCF51020.1 - 0.039 14.0 0.3 0.077 13.1 0.3 1.4 1 0 0 1 1 1 0 Putative addiction module component Aminotran_1_2 PF00155.21 CCF51021.1 - 4.2e-57 194.0 0.0 5e-57 193.7 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Esterase PF00756.20 CCF51022.1 - 2.1e-51 175.0 0.0 2.4e-51 174.8 0.0 1.0 1 0 0 1 1 1 1 Putative esterase Abhydrolase_2 PF02230.16 CCF51022.1 - 0.0054 16.6 0.0 0.0077 16.1 0.0 1.3 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Hydrolase_4 PF12146.8 CCF51022.1 - 0.0063 15.8 0.0 0.0084 15.4 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 CCF51022.1 - 0.0073 15.8 0.0 0.0092 15.5 0.0 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family Chlorophyllase2 PF12740.7 CCF51022.1 - 0.0075 15.2 0.0 0.015 14.3 0.0 1.4 1 0 0 1 1 1 1 Chlorophyllase enzyme Chlorophyllase PF07224.11 CCF51022.1 - 0.17 10.9 0.0 0.27 10.2 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase MIF4G PF02854.19 CCF51023.1 - 8.2e-54 182.4 0.5 1.9e-53 181.3 0.3 1.7 2 0 0 2 2 2 1 MIF4G domain eIF_4G1 PF12152.8 CCF51023.1 - 3.9e-19 68.6 0.4 3.9e-19 68.6 0.4 2.5 3 0 0 3 3 3 1 Eukaryotic translation initiation factor 4G1 MA3 PF02847.17 CCF51023.1 - 4.1e-07 30.0 0.1 1e-06 28.7 0.0 1.7 2 0 0 2 2 2 1 MA3 domain MgtE PF01769.16 CCF51024.1 - 2.2 8.7 7.5 6.8 7.1 7.5 1.9 1 0 0 1 1 1 0 Divalent cation transporter Hydrophobin PF01185.18 CCF51025.1 - 1.3e-12 48.2 8.9 3.5e-12 46.8 8.9 1.8 1 0 0 1 1 1 1 Fungal hydrophobin DUF1411 PF07199.11 CCF51025.1 - 0.3 10.7 1.8 2.2 7.9 0.2 2.8 2 2 0 2 2 2 0 Protein of unknown function (DUF1411) HSP70 PF00012.20 CCF51027.1 - 9.7e-233 773.7 4.7 1.1e-232 773.5 4.7 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 CCF51027.1 - 1.8e-18 66.4 1.0 1.6e-17 63.4 0.5 2.1 2 0 0 2 2 2 1 MreB/Mbl protein FGGY_C PF02782.16 CCF51027.1 - 0.0044 16.8 0.0 0.0097 15.6 0.0 1.6 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain BcrAD_BadFG PF01869.20 CCF51027.1 - 0.011 15.2 0.3 1.6 8.1 0.1 2.4 2 1 0 2 2 2 0 BadF/BadG/BcrA/BcrD ATPase family DDR PF08841.10 CCF51027.1 - 0.014 14.4 0.7 0.091 11.7 0.3 2.2 2 0 0 2 2 2 0 Diol dehydratase reactivase ATPase-like domain Ribosomal_S2 PF00318.20 CCF51028.1 - 4e-55 186.4 0.0 8.5e-54 182.0 0.0 2.1 1 1 0 1 1 1 1 Ribosomal protein S2 ABC_membrane PF00664.23 CCF51029.1 - 1.4e-84 284.0 32.2 6.6e-44 150.6 11.2 2.9 2 1 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 CCF51029.1 - 3.6e-62 208.9 0.0 1.5e-29 103.3 0.0 2.7 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 CCF51029.1 - 5.3e-15 55.5 2.9 1.4e-05 24.6 0.2 4.4 3 2 0 4 4 3 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 CCF51029.1 - 2.7e-08 34.4 2.5 0.0021 18.5 0.1 3.6 2 2 0 3 3 3 2 AAA ATPase domain AAA_22 PF13401.6 CCF51029.1 - 6.9e-07 29.6 2.4 0.11 12.8 0.2 4.1 2 2 0 2 2 2 2 AAA domain AAA_29 PF13555.6 CCF51029.1 - 1.7e-06 27.7 0.0 0.042 13.6 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_21 PF13304.6 CCF51029.1 - 3.7e-06 27.0 2.7 1.9 8.3 0.0 4.4 4 0 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system DUF87 PF01935.17 CCF51029.1 - 1.5e-05 25.2 2.5 0.026 14.6 0.0 3.2 2 1 0 2 2 2 2 Helicase HerA, central domain Zeta_toxin PF06414.12 CCF51029.1 - 2e-05 24.0 0.5 0.043 13.1 0.0 2.8 3 0 0 3 3 2 2 Zeta toxin AAA_18 PF13238.6 CCF51029.1 - 0.00011 22.7 0.3 0.21 12.2 0.1 3.3 3 1 0 3 3 3 1 AAA domain AAA_30 PF13604.6 CCF51029.1 - 0.00019 21.2 0.6 0.81 9.4 0.1 3.4 2 1 0 2 2 2 2 AAA domain AAA_33 PF13671.6 CCF51029.1 - 0.00027 21.1 0.2 1.8 8.7 0.0 3.6 3 0 0 3 3 3 2 AAA domain AAA_28 PF13521.6 CCF51029.1 - 0.00028 21.2 0.1 0.28 11.4 0.1 3.0 2 0 0 2 2 2 1 AAA domain AAA_15 PF13175.6 CCF51029.1 - 0.0003 20.6 0.0 0.54 9.9 0.0 2.3 2 0 0 2 2 2 2 AAA ATPase domain IstB_IS21 PF01695.17 CCF51029.1 - 0.00034 20.4 1.0 1.5 8.5 0.0 3.6 4 0 0 4 4 3 2 IstB-like ATP binding protein AAA_5 PF07728.14 CCF51029.1 - 0.0005 20.1 0.0 2.1 8.4 0.0 3.3 3 0 0 3 3 3 2 AAA domain (dynein-related subfamily) AAA_23 PF13476.6 CCF51029.1 - 0.00069 20.2 0.1 1.4 9.4 0.0 2.7 3 0 0 3 3 2 2 AAA domain RsgA_GTPase PF03193.16 CCF51029.1 - 0.0007 19.5 0.0 0.55 10.1 0.0 2.5 2 0 0 2 2 2 1 RsgA GTPase APS_kinase PF01583.20 CCF51029.1 - 0.0016 18.4 0.0 1.4 8.8 0.0 2.7 2 0 0 2 2 2 1 Adenylylsulphate kinase ABC_ATPase PF09818.9 CCF51029.1 - 0.0021 16.9 0.2 0.89 8.3 0.0 2.9 3 0 0 3 3 3 1 Predicted ATPase of the ABC class RNA_helicase PF00910.22 CCF51029.1 - 0.0047 17.3 0.0 6 7.3 0.0 3.0 2 0 0 2 2 2 0 RNA helicase AAA PF00004.29 CCF51029.1 - 0.005 17.3 0.6 56 4.2 0.1 4.6 3 1 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) PRK PF00485.18 CCF51029.1 - 0.0092 15.7 0.0 1.3 8.7 0.0 2.6 2 0 0 2 2 2 1 Phosphoribulokinase / Uridine kinase family G-alpha PF00503.20 CCF51029.1 - 0.011 14.9 0.0 3.5 6.7 0.0 2.4 2 0 0 2 2 2 0 G-protein alpha subunit CPT PF07931.12 CCF51029.1 - 0.013 15.3 0.1 4.1 7.2 0.0 3.5 4 0 0 4 4 3 0 Chloramphenicol phosphotransferase-like protein SbcCD_C PF13558.6 CCF51029.1 - 0.027 14.7 0.6 1.2 9.5 0.1 3.3 2 2 0 2 2 2 0 Putative exonuclease SbcCD, C subunit Ploopntkinase3 PF18751.1 CCF51029.1 - 0.039 13.9 0.3 5.5 6.9 0.0 3.2 3 0 0 3 3 3 0 P-loop Nucleotide Kinase3 AAA_25 PF13481.6 CCF51029.1 - 0.04 13.5 0.6 4 7.0 0.0 3.2 4 0 0 4 4 3 0 AAA domain tRNA_lig_kinase PF08303.11 CCF51029.1 - 0.056 13.5 0.0 12 6.0 0.0 2.6 2 0 0 2 2 2 0 tRNA ligase kinase domain NB-ARC PF00931.22 CCF51029.1 - 0.072 12.3 1.0 1.8 7.7 0.0 2.7 3 0 0 3 3 3 0 NB-ARC domain NACHT PF05729.12 CCF51029.1 - 0.11 12.3 0.1 16 5.4 0.0 3.1 2 0 0 2 2 2 0 NACHT domain AAA_24 PF13479.6 CCF51029.1 - 0.12 12.1 0.1 8.8 6.0 0.0 2.5 2 0 0 2 2 2 0 AAA domain CbiA PF01656.23 CCF51029.1 - 0.18 11.8 0.1 32 4.6 0.0 2.7 2 0 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_17 PF13207.6 CCF51029.1 - 0.19 12.1 0.2 32 4.9 0.1 2.7 2 0 0 2 2 2 0 AAA domain Retrotran_gag_2 PF14223.6 CCF51030.1 - 4.3e-07 29.7 0.2 5.8e-07 29.3 0.2 1.3 1 0 0 1 1 1 1 gag-polypeptide of LTR copia-type DUF1496 PF07383.12 CCF51030.1 - 0.046 13.3 0.0 0.14 11.8 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1496) Cyclin_N PF00134.23 CCF51031.1 - 1.9e-08 34.1 0.0 3.2e-08 33.4 0.0 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.11 CCF51031.1 - 3.6e-05 24.2 4.5 3.6e-05 24.2 4.5 2.7 2 1 0 2 2 2 1 Cyclin adh_short PF00106.25 CCF51032.1 - 4e-39 134.1 0.3 5.6e-39 133.6 0.3 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF51032.1 - 1.7e-21 76.8 0.1 2.3e-21 76.4 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF51032.1 - 9.4e-06 25.7 0.1 1.8e-05 24.7 0.1 1.4 1 1 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 CCF51032.1 - 0.0018 17.5 0.1 0.0026 16.9 0.1 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Sacchrp_dh_NADP PF03435.18 CCF51032.1 - 0.014 15.7 0.2 0.27 11.5 0.0 2.6 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain NAD_binding_10 PF13460.6 CCF51032.1 - 0.025 14.4 0.1 0.037 13.9 0.1 1.5 1 1 0 1 1 1 0 NAD(P)H-binding Dcc1 PF09724.9 CCF51032.1 - 0.13 11.6 0.0 0.16 11.3 0.0 1.2 1 0 0 1 1 1 0 Sister chromatid cohesion protein Dcc1 tRNA-synt_2 PF00152.20 CCF51033.1 - 6.2e-91 304.7 0.0 8.1e-91 304.4 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 CCF51033.1 - 6.9e-12 45.2 0.0 1.8e-11 43.8 0.0 1.7 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain Gcn1_N PF12074.8 CCF51034.1 - 8.9e-69 232.5 20.4 3.1e-68 230.7 13.3 5.0 5 2 0 5 5 5 1 Generalcontrol nonderepressible 1 (Gcn1) N-terminal HEAT PF02985.22 CCF51034.1 - 5e-31 104.1 31.0 0.39 11.1 0.1 23.1 23 0 0 23 23 23 6 HEAT repeat HEAT_2 PF13646.6 CCF51034.1 - 4.4e-21 75.1 54.6 6.4e-06 26.5 0.0 14.4 13 3 4 17 17 17 7 HEAT repeats HEAT_EZ PF13513.6 CCF51034.1 - 8.5e-21 74.1 42.1 8.6e-05 22.9 0.0 18.6 16 2 2 19 19 18 5 HEAT-like repeat CLASP_N PF12348.8 CCF51034.1 - 2.6e-14 53.3 0.2 0.00022 20.9 0.0 6.6 5 1 2 7 7 6 3 CLASP N terminal Cnd1 PF12717.7 CCF51034.1 - 1.9e-13 50.7 0.0 0.5 10.4 0.0 10.4 6 2 5 11 11 11 1 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 CCF51034.1 - 1.6e-09 38.2 0.0 1.8 9.2 0.0 8.8 8 3 2 11 11 10 1 Vacuolar 14 Fab1-binding region RIX1 PF08167.12 CCF51034.1 - 1.1e-06 28.6 2.1 0.76 9.5 0.0 6.5 6 0 0 6 6 6 2 rRNA processing/ribosome biogenesis Cnd3 PF12719.7 CCF51034.1 - 7.7e-05 22.0 0.6 1.2 8.3 0.0 4.4 4 0 0 4 4 4 1 Nuclear condensing complex subunits, C-term domain DUF3437 PF11919.8 CCF51034.1 - 9.4e-05 22.3 0.3 1.6 8.7 0.0 5.8 7 0 0 7 7 6 1 Domain of unknown function (DUF3437) RTP1_C1 PF10363.9 CCF51034.1 - 0.0001 22.5 0.0 0.24 11.6 0.0 5.0 3 1 0 3 3 3 1 Required for nuclear transport of RNA pol II C-terminus 1 RasGEF_N_2 PF14663.6 CCF51034.1 - 0.00024 21.5 0.8 0.98 9.8 0.0 5.0 6 0 0 6 6 6 1 Rapamycin-insensitive companion of mTOR RasGEF_N domain Cohesin_HEAT PF12765.7 CCF51034.1 - 0.0013 19.0 3.2 0.32 11.3 0.2 4.6 3 0 0 3 3 3 1 HEAT repeat associated with sister chromatid cohesion Arm PF00514.23 CCF51034.1 - 0.0027 17.7 11.3 7.7 6.7 0.1 9.2 9 0 0 9 9 8 1 Armadillo/beta-catenin-like repeat FANCI_S2 PF14676.6 CCF51034.1 - 0.0079 16.5 2.1 0.62 10.4 0.1 4.6 4 1 0 4 4 3 1 FANCI solenoid 2 Dopey_N PF04118.14 CCF51034.1 - 0.061 12.4 0.1 27 3.7 0.0 3.7 2 2 2 4 4 4 0 Dopey, N-terminal Effector_1 PF04518.12 CCF51034.1 - 0.41 9.7 3.7 0.74 8.9 3.1 1.7 2 0 0 2 2 2 0 Effector from type III secretion system NUC173 PF08161.12 CCF51034.1 - 3.5 7.2 5.6 47 3.5 0.0 5.5 7 1 1 8 8 7 0 NUC173 domain Mito_carr PF00153.27 CCF51035.1 - 2.4e-48 162.0 0.5 5.9e-15 55.0 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein HMD PF03201.16 CCF51035.1 - 0.098 12.9 0.0 15 5.9 0.0 2.6 3 0 0 3 3 3 0 H2-forming N5,N10-methylene-tetrahydromethanopterin dehydrogenase Anoctamin PF04547.12 CCF51036.1 - 2.7e-99 333.1 2.4 3.4e-99 332.7 2.4 1.1 1 0 0 1 1 1 1 Calcium-activated chloride channel E1-E2_ATPase PF00122.20 CCF51036.1 - 2 7.9 3.9 4.4 6.8 3.9 1.5 1 0 0 1 1 1 0 E1-E2 ATPase LSM PF01423.22 CCF51037.1 - 2.1e-16 59.3 0.0 3.4e-16 58.7 0.0 1.3 1 0 0 1 1 1 1 LSM domain zf-CCCH_2 PF14608.6 CCF51038.1 - 3.8e-17 62.1 32.6 1.4e-05 25.3 1.4 4.3 4 0 0 4 4 4 4 RNA-binding, Nab2-type zinc finger TraT PF05818.12 CCF51038.1 - 0.0045 16.7 0.1 0.0083 15.8 0.1 1.4 1 0 0 1 1 1 1 Enterobacterial TraT complement resistance protein Nab2 PF11517.8 CCF51038.1 - 0.031 14.6 0.0 0.05 13.9 0.0 1.2 1 0 0 1 1 1 0 Nuclear abundant poly(A) RNA-bind protein 2 (Nab2) EF-hand_6 PF13405.6 CCF51041.1 - 6.1e-11 41.3 0.4 6.1e-05 22.6 0.0 2.8 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 CCF51041.1 - 7.3e-10 37.7 2.7 8.2e-05 21.9 0.1 3.1 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.6 CCF51041.1 - 1.1e-09 38.6 0.2 0.00028 21.3 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 CCF51041.1 - 3.7e-07 29.3 1.8 0.0013 18.2 0.2 2.7 2 0 0 2 2 2 2 EF hand EF-hand_9 PF14658.6 CCF51041.1 - 3.9e-06 27.1 0.0 0.0029 17.9 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 CCF51041.1 - 0.0018 18.1 1.1 0.36 10.7 0.0 2.7 2 1 0 2 2 2 2 EF-hand domain pair NAPRTase PF04095.16 CCF51043.1 - 3.1e-53 180.9 0.0 4.8e-53 180.3 0.0 1.3 1 0 0 1 1 1 1 Nicotinate phosphoribosyltransferase (NAPRTase) family NAPRTase_N PF17767.1 CCF51043.1 - 6.1e-35 120.3 0.1 8.7e-35 119.8 0.1 1.2 1 0 0 1 1 1 1 Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain Glyco_transf_90 PF05686.12 CCF51044.1 - 1.2e-27 96.8 2.7 5.1e-24 84.9 0.8 2.7 2 1 0 2 2 2 2 Glycosyl transferase family 90 DUF3357 PF11837.8 CCF51044.1 - 0.051 14.0 0.0 0.14 12.6 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3357) E1_dh PF00676.20 CCF51045.1 - 2.1e-64 217.3 0.0 2.9e-64 216.9 0.0 1.2 1 0 0 1 1 1 1 Dehydrogenase E1 component Transket_pyr PF02779.24 CCF51045.1 - 1.3e-62 210.6 0.0 2.1e-62 210.0 0.0 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain OxoGdeHyase_C PF16870.5 CCF51045.1 - 2.5e-47 160.4 0.0 6.7e-47 159.0 0.0 1.8 2 0 0 2 2 2 1 2-oxoglutarate dehydrogenase C-terminal 2-oxogl_dehyd_N PF16078.5 CCF51045.1 - 1.2e-16 60.0 0.9 2.9e-16 58.8 0.1 2.1 2 0 0 2 2 2 1 2-oxoglutarate dehydrogenase N-terminus Y_phosphatase PF00102.27 CCF51047.1 - 2.6e-52 177.7 0.0 7.4e-27 94.4 0.0 3.2 3 0 0 3 3 3 3 Protein-tyrosine phosphatase Rhodanese PF00581.20 CCF51047.1 - 0.077 13.5 0.0 2.8 8.5 0.0 3.2 4 0 0 4 4 4 0 Rhodanese-like domain PTPlike_phytase PF14566.6 CCF51047.1 - 0.084 13.0 0.0 1.4 9.0 0.0 2.3 2 0 0 2 2 2 0 Inositol hexakisphosphate Y_phosphatase3 PF13350.6 CCF51047.1 - 0.12 12.3 0.0 0.24 11.3 0.0 1.4 1 0 0 1 1 1 0 Tyrosine phosphatase family DSPc PF00782.20 CCF51047.1 - 0.22 11.3 0.2 0.49 10.2 0.2 1.5 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain Cwf_Cwc_15 PF04889.12 CCF51048.1 - 6.6e-75 252.0 19.0 7.8e-75 251.8 19.0 1.0 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein MFAP1 PF06991.11 CCF51048.1 - 0.15 11.9 20.8 0.27 11.1 20.8 1.5 1 0 0 1 1 1 0 Microfibril-associated/Pre-mRNA processing Nop14 PF04147.12 CCF51048.1 - 0.24 9.6 23.4 0.3 9.2 23.4 1.1 1 0 0 1 1 1 0 Nop14-like family RRN3 PF05327.11 CCF51048.1 - 0.88 8.0 10.5 1.1 7.7 10.5 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 CDC45 PF02724.14 CCF51048.1 - 0.97 7.6 19.1 1.3 7.2 19.1 1.1 1 0 0 1 1 1 0 CDC45-like protein PPP4R2 PF09184.11 CCF51048.1 - 1 8.9 18.0 1.6 8.2 18.0 1.3 1 0 0 1 1 1 0 PPP4R2 DUF966 PF06136.13 CCF51048.1 - 1.6 8.4 14.8 2.1 8.0 14.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF966) NPR3 PF03666.13 CCF51048.1 - 2.6 6.7 9.4 3.6 6.3 9.4 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Pannexin_like PF12534.8 CCF51048.1 - 4.5 6.3 7.0 7.1 5.6 7.0 1.3 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 DUF4746 PF15928.5 CCF51048.1 - 4.7 6.6 14.0 6.6 6.1 14.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Presenilin PF01080.17 CCF51048.1 - 5.1 5.8 10.3 6.3 5.5 10.3 1.4 1 0 0 1 1 1 0 Presenilin Astro_capsid_p PF12226.8 CCF51048.1 - 6.2 5.9 12.1 8.2 5.5 12.1 1.2 1 0 0 1 1 1 0 Turkey astrovirus capsid protein SURF2 PF05477.11 CCF51048.1 - 7.2 6.2 16.5 11 5.6 16.5 1.3 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) Vfa1 PF08432.10 CCF51048.1 - 9.8 6.5 14.6 17 5.7 14.6 1.5 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 FKBP_C PF00254.28 CCF51049.1 - 6.6e-36 122.5 0.0 8.5e-36 122.2 0.0 1.2 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase Pkinase PF00069.25 CCF51050.1 - 1e-70 238.1 0.0 1.3e-70 237.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF51050.1 - 4.7e-36 124.4 0.0 6.5e-36 123.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCF51050.1 - 0.0029 17.0 0.0 0.004 16.5 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 CCF51050.1 - 0.038 13.3 0.0 0.12 11.7 0.0 1.8 3 0 0 3 3 3 0 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.9 CCF51050.1 - 0.16 11.4 0.0 0.34 10.4 0.0 1.5 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL UPF0220 PF05255.11 CCF51051.1 - 4.5e-52 176.0 0.0 5.2e-52 175.7 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0220) PrgI PF12666.7 CCF51051.1 - 0.12 13.1 0.0 0.12 13.1 0.0 2.1 2 1 0 2 2 2 0 PrgI family protein ApbA PF02558.16 CCF51052.1 - 1.2e-28 99.6 0.1 2e-28 98.9 0.1 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA ApbA_C PF08546.11 CCF51052.1 - 1.5e-25 89.8 0.0 3.2e-25 88.7 0.0 1.5 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal Sacchrp_dh_NADP PF03435.18 CCF51052.1 - 0.0077 16.5 0.0 0.021 15.1 0.0 1.7 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain DAO PF01266.24 CCF51052.1 - 0.023 14.3 1.0 0.056 13.0 0.5 1.8 1 1 1 2 2 2 0 FAD dependent oxidoreductase ThiF PF00899.21 CCF51052.1 - 0.1 11.9 0.0 0.19 11.1 0.0 1.3 1 0 0 1 1 1 0 ThiF family Pyr_redox PF00070.27 CCF51052.1 - 0.11 13.1 0.0 0.25 11.9 0.0 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase polyprenyl_synt PF00348.17 CCF51053.1 - 5.6e-55 186.2 0.0 8.5e-55 185.6 0.0 1.3 1 0 0 1 1 1 1 Polyprenyl synthetase RNA_pol_Rpb8 PF03870.15 CCF51054.1 - 2.6e-46 157.3 0.0 3.3e-46 156.9 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb8 E1-E2_ATPase PF00122.20 CCF51055.1 - 1.6e-48 164.7 0.8 1.6e-48 164.7 0.8 2.5 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 CCF51055.1 - 3.2e-31 108.4 0.2 8.9e-31 107.0 0.2 1.8 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 CCF51055.1 - 1.6e-21 77.6 0.8 5.8e-20 72.5 0.8 2.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 CCF51055.1 - 2.1e-11 43.4 0.0 4.4e-11 42.3 0.0 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Cation_ATPase PF13246.6 CCF51055.1 - 5.3e-08 32.8 0.0 1.2e-07 31.7 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 CCF51055.1 - 5.8e-05 23.0 0.8 0.0024 17.7 0.6 2.3 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 CCF51055.1 - 0.12 12.8 0.0 1.1 9.6 0.0 2.2 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase OppC_N PF12911.7 CCF51055.1 - 4.2 7.4 5.0 1.3 9.1 0.6 2.5 2 0 0 2 2 2 0 N-terminal TM domain of oligopeptide transport permease C Med17 PF10156.9 CCF51056.1 - 2.6e-10 39.6 6.7 6.8e-08 31.6 0.1 3.1 3 0 0 3 3 3 2 Subunit 17 of Mediator complex SDA1 PF05285.12 CCF51056.1 - 6.7e-05 22.5 6.4 6.7e-05 22.5 6.4 2.4 3 0 0 3 3 3 1 SDA1 CPSF100_C PF13299.6 CCF51056.1 - 0.0063 16.7 1.8 0.0063 16.7 1.8 2.3 3 0 0 3 3 1 1 Cleavage and polyadenylation factor 2 C-terminal DUF2052 PF09747.9 CCF51056.1 - 0.0075 16.4 4.9 0.0075 16.4 4.9 3.1 3 0 0 3 3 3 1 Coiled-coil domain containing protein (DUF2052) RNA_pol_Rpc4 PF05132.14 CCF51056.1 - 0.0099 16.3 7.1 0.016 15.6 4.1 2.8 2 0 0 2 2 2 1 RNA polymerase III RPC4 SpoIIP PF07454.11 CCF51056.1 - 0.016 14.7 5.1 0.036 13.5 5.1 1.5 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Presenilin PF01080.17 CCF51056.1 - 0.031 13.1 0.6 0.066 12.0 0.6 1.5 1 0 0 1 1 1 0 Presenilin U79_P34 PF03064.16 CCF51056.1 - 0.036 13.4 12.6 0.082 12.3 12.6 1.5 1 0 0 1 1 1 0 HSV U79 / HCMV P34 THOC2_N PF16134.5 CCF51056.1 - 0.045 12.4 8.4 0.08 11.6 8.4 1.3 1 0 0 1 1 1 0 THO complex subunit 2 N-terminus DUF913 PF06025.12 CCF51056.1 - 0.063 12.2 1.0 0.15 11.0 1.0 1.5 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Connexin PF00029.19 CCF51056.1 - 0.12 12.2 5.7 0.23 11.2 5.7 1.4 1 0 0 1 1 1 0 Connexin Rtf2 PF04641.12 CCF51056.1 - 0.18 11.2 12.0 0.32 10.3 12.0 1.3 1 0 0 1 1 1 0 Rtf2 RING-finger DUF4770 PF15994.5 CCF51056.1 - 0.2 11.9 3.8 0.4 10.9 3.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) DUF1682 PF07946.14 CCF51056.1 - 0.36 10.0 18.4 0.73 9.0 18.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) RRN3 PF05327.11 CCF51056.1 - 0.42 9.1 3.3 0.8 8.2 3.3 1.4 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 NARP1 PF12569.8 CCF51056.1 - 0.63 8.9 13.5 1.1 8.1 13.5 1.3 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 FAM176 PF14851.6 CCF51056.1 - 0.94 9.1 12.7 0.12 12.1 2.2 3.1 3 0 0 3 3 3 0 FAM176 family Fmp27 PF10344.9 CCF51056.1 - 1.6 6.7 4.7 2.4 6.2 4.7 1.1 1 0 0 1 1 1 0 Mitochondrial protein from FMP27 NPR3 PF03666.13 CCF51056.1 - 1.8 7.3 5.9 3 6.5 5.9 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 TRAP_alpha PF03896.16 CCF51056.1 - 2 7.6 12.8 0.016 14.4 4.3 1.7 2 0 0 2 2 1 0 Translocon-associated protein (TRAP), alpha subunit AAR2 PF05282.11 CCF51056.1 - 2.4 7.5 5.2 0.82 9.0 2.2 1.6 2 0 0 2 2 2 0 AAR2 protein DUF2151 PF10221.9 CCF51056.1 - 2.5 6.6 6.9 4.3 5.8 6.9 1.2 1 0 0 1 1 1 0 Cell cycle and development regulator Serinc PF03348.15 CCF51056.1 - 2.6 6.9 4.3 4.4 6.1 4.3 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) TAF4 PF05236.14 CCF51056.1 - 2.8 7.6 14.7 12 5.5 14.7 2.1 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family Zip PF02535.22 CCF51056.1 - 3.2 6.9 4.1 5.6 6.1 4.1 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter EIIBC-GUT_N PF03612.14 CCF51056.1 - 3.3 7.4 8.3 9 6.0 8.3 1.7 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus DUF2828 PF11443.8 CCF51056.1 - 4.2 5.3 7.1 6.3 4.8 7.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) DDHD PF02862.17 CCF51056.1 - 4.9 7.3 6.8 0.29 11.3 0.5 2.1 2 1 0 2 2 2 0 DDHD domain Eapp_C PF10238.9 CCF51056.1 - 7.9 6.5 9.7 0.99 9.5 5.2 1.7 2 0 0 2 2 1 0 E2F-associated phosphoprotein Usp PF00582.26 CCF51056.1 - 8.3 6.9 6.5 34 4.9 6.5 2.1 1 0 0 1 1 1 0 Universal stress protein family YL1 PF05764.13 CCF51056.1 - 8.9 6.3 33.8 0.059 13.5 17.3 2.9 3 0 0 3 3 3 0 YL1 nuclear protein RPN2_C PF18004.1 CCF51056.1 - 8.9 6.2 26.1 0.18 11.7 16.9 2.5 3 0 0 3 3 3 0 26S proteasome regulatory subunit RPN2 C-terminal domain RR_TM4-6 PF06459.12 CCF51056.1 - 9.4 6.0 18.9 0.065 13.0 9.2 2.2 3 0 0 3 3 3 0 Ryanodine Receptor TM 4-6 CobT PF06213.12 CCF51056.1 - 9.6 5.5 21.1 0.5 9.7 12.5 2.5 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT Lectin_leg-like PF03388.13 CCF51057.1 - 1.4e-61 207.8 0.1 2.4e-61 207.0 0.1 1.2 1 0 0 1 1 1 1 Legume-like lectin family Lectin_legB PF00139.19 CCF51057.1 - 2.2e-06 27.4 0.0 2.3e-05 24.1 0.0 2.1 1 1 0 1 1 1 1 Legume lectin domain FAD_binding_4 PF01565.23 CCF51058.1 - 6.5e-11 42.1 0.6 0.0005 19.8 0.1 2.8 3 0 0 3 3 3 2 FAD binding domain BBE PF08031.12 CCF51058.1 - 3.9e-07 30.1 0.0 9.1e-07 28.9 0.0 1.5 1 0 0 1 1 1 1 Berberine and berberine like Coilin_N PF15862.5 CCF51058.1 - 0.016 15.1 0.0 0.11 12.3 0.0 2.5 3 1 0 3 3 3 0 Coilin N-terminus Bromodomain PF00439.25 CCF51059.1 - 1.3e-20 73.2 0.1 2.8e-20 72.2 0.1 1.5 1 0 0 1 1 1 1 Bromodomain Bromo_TP PF07524.13 CCF51059.1 - 3.5e-06 26.9 0.1 9.3e-05 22.4 0.1 2.5 2 0 0 2 2 2 1 Bromodomain associated COPI_C PF06957.11 CCF51059.1 - 0.33 9.6 2.5 1 8.1 1.5 2.0 2 0 0 2 2 2 0 Coatomer (COPI) alpha subunit C-terminus adh_short_C2 PF13561.6 CCF51060.1 - 3.3e-23 82.5 0.0 1.7e-17 63.8 0.0 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCF51060.1 - 1.1e-20 73.9 0.0 4.4e-20 72.0 0.0 1.8 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CCF51060.1 - 8e-05 22.6 0.1 0.00027 20.9 0.0 1.9 3 0 0 3 3 3 1 KR domain GDP_Man_Dehyd PF16363.5 CCF51060.1 - 0.049 13.0 0.0 0.066 12.6 0.0 1.1 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Pyrid_ox_like PF16242.5 CCF51061.1 - 9.4e-28 96.7 0.0 1.5e-27 96.1 0.0 1.3 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase like Putative_PNPOx PF01243.20 CCF51061.1 - 1.4e-10 41.3 0.0 1.4e-09 38.0 0.0 2.0 2 0 0 2 2 2 1 Pyridoxamine 5'-phosphate oxidase GIT_SHD PF08518.11 CCF51062.1 - 7e-25 86.3 7.4 5.5e-14 51.5 1.4 2.7 2 0 0 2 2 2 2 Spa2 homology domain (SHD) of GIT GIT1_C PF12205.8 CCF51062.1 - 7.1e-05 22.9 0.3 7.1e-05 22.9 0.3 3.7 3 1 1 4 4 4 1 G protein-coupled receptor kinase-interacting protein 1 C term SLATT_fungal PF18142.1 CCF51062.1 - 0.13 12.3 0.1 0.13 12.3 0.1 3.5 2 1 0 3 3 3 0 SMODS and SLOG-associating 2TM effector domain YabA PF06156.13 CCF51062.1 - 0.5 11.0 17.6 3 8.5 3.5 3.5 1 1 0 2 2 2 0 Initiation control protein YabA FlxA PF14282.6 CCF51062.1 - 0.82 9.7 34.8 0.013 15.5 15.7 4.2 2 2 0 4 4 4 0 FlxA-like protein TPR_MLP1_2 PF07926.12 CCF51062.1 - 1.6 8.8 37.5 3.8 7.6 16.4 4.0 2 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein Spc7 PF08317.11 CCF51062.1 - 1.6 7.5 35.7 0.046 12.6 26.9 2.8 3 1 0 3 3 3 0 Spc7 kinetochore protein NPV_P10 PF05531.12 CCF51062.1 - 2.2 8.8 14.4 0.16 12.5 1.2 4.4 4 0 0 4 4 4 0 Nucleopolyhedrovirus P10 protein GAS PF13851.6 CCF51062.1 - 6.8 6.0 31.1 2.1 7.7 8.1 3.2 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding APG6_N PF17675.1 CCF51062.1 - 7.6 7.1 38.0 0.91 10.1 12.2 3.9 2 1 1 3 3 3 0 Apg6 coiled-coil region zf-C2H2 PF00096.26 CCF51063.1 - 7.7e-05 22.9 3.3 0.091 13.3 0.6 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CCF51063.1 - 0.0001 22.8 3.7 0.01 16.6 0.6 3.0 2 0 0 2 2 2 2 C2H2-type zinc finger Alpha-amylase_C PF02806.18 CCF51064.1 - 7.1e-26 90.5 0.1 1.4e-25 89.6 0.1 1.5 1 0 0 1 1 1 1 Alpha amylase, C-terminal all-beta domain CBM_48 PF02922.18 CCF51064.1 - 3.5e-17 62.5 0.0 9.4e-17 61.2 0.0 1.8 1 0 0 1 1 1 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) Alpha-amylase PF00128.24 CCF51064.1 - 3.2e-13 49.9 0.1 5.2e-11 42.7 0.1 2.3 1 1 1 2 2 2 2 Alpha amylase, catalytic domain hDGE_amylase PF14701.6 CCF51064.1 - 0.02 14.0 0.0 0.062 12.4 0.0 1.7 2 0 0 2 2 2 0 Glycogen debranching enzyme, glucanotransferase domain PBP1_TM PF14812.6 CCF51066.1 - 0.042 14.2 0.8 0.042 14.2 0.8 2.2 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal CCDC117 PF15810.5 CCF51066.1 - 0.048 14.0 0.7 0.2 11.9 0.0 2.3 2 1 0 2 2 2 0 Coiled-coil domain-containing protein 117 DUF5471 PF17565.2 CCF51066.1 - 0.97 9.8 0.0 0.97 9.8 0.0 2.5 3 0 0 3 3 3 0 Family of unknown function (DUF5471) RVT_2 PF07727.14 CCF51067.1 - 2.4e-12 47.0 0.0 3.4e-12 46.5 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) G-patch PF01585.23 CCF51068.1 - 7.3e-09 35.4 1.1 1.9e-08 34.0 1.1 1.8 1 0 0 1 1 1 1 G-patch domain SDA1 PF05285.12 CCF51068.1 - 6.8e-05 22.5 41.1 0.0066 15.9 14.5 2.2 2 0 0 2 2 2 2 SDA1 RR_TM4-6 PF06459.12 CCF51068.1 - 0.00081 19.3 33.7 0.055 13.3 11.0 2.2 2 0 0 2 2 2 2 Ryanodine Receptor TM 4-6 YL1 PF05764.13 CCF51068.1 - 0.0035 17.5 49.5 0.032 14.3 21.8 2.2 2 0 0 2 2 2 2 YL1 nuclear protein DUF3807 PF12720.7 CCF51068.1 - 0.018 15.3 40.0 0.21 11.8 14.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3807) CDC45 PF02724.14 CCF51068.1 - 0.023 13.0 37.2 0.023 13.0 14.8 2.1 2 0 0 2 2 2 0 CDC45-like protein DUF5427 PF10310.9 CCF51068.1 - 0.041 12.9 32.8 0.35 9.8 11.6 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5427) TFIIF_alpha PF05793.12 CCF51068.1 - 0.041 12.5 45.0 0.062 11.9 17.2 2.2 2 0 0 2 2 2 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Mitofilin PF09731.9 CCF51068.1 - 0.041 12.7 39.3 0.073 11.9 14.4 2.2 2 0 0 2 2 2 0 Mitochondrial inner membrane protein G-patch_2 PF12656.7 CCF51068.1 - 0.062 13.4 1.0 0.062 13.4 1.0 4.5 3 2 0 3 3 1 0 G-patch domain SpoIIIAH PF12685.7 CCF51068.1 - 0.09 12.6 34.5 0.12 12.2 10.0 2.5 2 0 0 2 2 2 0 SpoIIIAH-like protein CCSAP PF15748.5 CCF51068.1 - 0.11 12.6 36.1 1.1 9.4 13.3 2.2 2 0 0 2 2 2 0 Centriole, cilia and spindle-associated TCP PF03634.13 CCF51068.1 - 0.15 12.6 32.1 0.21 12.1 6.1 2.5 2 0 0 2 2 2 0 TCP family transcription factor DUF2052 PF09747.9 CCF51068.1 - 0.25 11.5 31.9 0.26 11.4 10.3 2.3 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) Vfa1 PF08432.10 CCF51068.1 - 0.49 10.7 49.5 2 8.7 20.3 2.4 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 BAF1_ABF1 PF04684.13 CCF51068.1 - 0.52 9.3 32.2 1.5 7.8 10.9 2.1 2 0 0 2 2 2 0 BAF1 / ABF1 chromatin reorganising factor NAM-associated PF14303.6 CCF51068.1 - 0.87 10.3 46.0 1.6 9.5 17.3 2.4 2 0 0 2 2 2 0 No apical meristem-associated C-terminal domain Apt1 PF10351.9 CCF51068.1 - 1.1 8.0 28.9 0.46 9.3 12.2 2.1 2 0 0 2 2 2 0 Golgi-body localisation protein domain DUF5523 PF17661.1 CCF51068.1 - 1.2 8.8 32.7 0.98 9.1 10.9 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5523) DUF913 PF06025.12 CCF51068.1 - 1.2 8.0 21.7 0.78 8.6 4.5 2.1 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) Endostatin PF06482.11 CCF51068.1 - 3.2 7.1 12.3 5.6 6.3 2.0 2.2 2 0 0 2 2 2 0 Collagenase NC10 and Endostatin DUF4614 PF15391.6 CCF51068.1 - 3.7 7.5 35.9 0.85 9.6 9.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4614) EPL1 PF10513.9 CCF51068.1 - 5.1 7.5 29.5 4.3 7.7 10.1 2.8 3 0 0 3 3 3 0 Enhancer of polycomb-like FAM60A PF15396.6 CCF51068.1 - 6 6.8 35.9 7.1 6.6 14.6 2.3 2 0 0 2 2 2 0 Protein Family FAM60A VSG_B PF13206.6 CCF51068.1 - 7.9 5.6 33.3 0.23 10.7 7.7 2.2 2 0 0 2 2 2 0 Trypanosomal VSG domain PDCD2_C PF04194.13 CCF51068.1 - 8.2 6.5 27.6 8.7 6.4 11.1 2.5 2 0 0 2 2 2 0 Programmed cell death protein 2, C-terminal putative domain XAP5 PF04921.14 CCF51068.1 - 8.7 6.1 37.2 6.2 6.6 15.0 2.4 2 0 0 2 2 2 0 XAP5, circadian clock regulator AF-4 PF05110.13 CCF51068.1 - 8.9 4.3 46.8 3.4 5.6 15.6 2.1 2 0 0 2 2 2 0 AF-4 proto-oncoprotein WD40 PF00400.32 CCF51069.1 - 2.7e-09 37.5 14.8 0.00019 22.1 0.1 5.9 5 1 0 5 5 5 3 WD domain, G-beta repeat RWD PF05773.22 CCF51069.1 - 0.00029 21.1 0.0 0.00078 19.7 0.0 1.7 1 0 0 1 1 1 1 RWD domain G-alpha PF00503.20 CCF51071.1 - 1.3e-113 379.7 0.4 1.5e-113 379.5 0.4 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 CCF51071.1 - 1.4e-15 57.2 0.1 5.9e-10 38.9 0.0 2.5 2 0 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 CCF51071.1 - 1.4e-05 24.5 0.1 0.15 11.4 0.0 2.3 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region Roc PF08477.13 CCF51071.1 - 0.0031 17.7 0.2 0.83 9.9 0.1 2.5 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase AAA_29 PF13555.6 CCF51071.1 - 0.066 13.0 0.0 0.15 11.8 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain RNA_pol_A_bac PF01000.26 CCF51071.1 - 0.12 12.7 0.0 0.25 11.8 0.0 1.5 1 0 0 1 1 1 0 RNA polymerase Rpb3/RpoA insert domain MMR_HSR1 PF01926.23 CCF51071.1 - 0.13 12.4 0.1 13 6.0 0.0 3.0 1 1 1 2 2 2 0 50S ribosome-binding GTPase Mito_carr PF00153.27 CCF51073.1 - 1.1e-51 172.7 5.0 2.5e-18 65.8 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Bacteriocin_IIc PF10439.9 CCF51073.1 - 6.5 6.9 8.4 10 6.3 0.3 3.5 3 0 0 3 3 3 0 Bacteriocin class II with double-glycine leader peptide RhoGEF PF00621.20 CCF51074.1 - 8.3e-34 117.4 0.0 6.2e-29 101.5 0.0 2.6 3 0 0 3 3 3 2 RhoGEF domain Herpes_LMP1 PF05297.11 CCF51074.1 - 5 6.2 5.0 11 5.1 5.0 1.5 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) Sugar_tr PF00083.24 CCF51075.1 - 3.1e-104 349.4 21.6 3.5e-104 349.2 21.6 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF51075.1 - 1.1e-28 100.2 25.9 3.9e-27 95.1 16.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 CCF51075.1 - 1.4e-06 27.1 2.4 1.4e-06 27.1 2.4 2.1 2 1 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Phage_holin_3_2 PF04550.12 CCF51075.1 - 2.9 8.5 8.7 0.18 12.4 1.3 2.7 2 1 1 3 3 3 0 Phage holin family 2 ADH_N PF08240.12 CCF51076.1 - 5.9e-24 84.1 1.2 1.1e-23 83.2 1.2 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CCF51076.1 - 1.7e-16 60.4 0.0 4.3e-16 59.1 0.0 1.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CCF51076.1 - 0.00013 23.0 0.0 0.00044 21.3 0.0 1.9 3 0 0 3 3 2 1 Zinc-binding dehydrogenase PDZ_6 PF17820.1 CCF51076.1 - 0.0045 16.8 0.1 0.011 15.6 0.1 1.7 1 0 0 1 1 1 1 PDZ domain 2-Hacid_dh_C PF02826.19 CCF51076.1 - 0.0071 15.7 0.0 0.012 15.0 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain adh_short PF00106.25 CCF51076.1 - 0.027 13.9 0.2 0.092 12.2 0.0 2.0 3 0 0 3 3 3 0 short chain dehydrogenase GFO_IDH_MocA PF01408.22 CCF51076.1 - 0.042 14.7 0.1 0.45 11.4 0.0 2.2 2 0 0 2 2 2 0 Oxidoreductase family, NAD-binding Rossmann fold PDZ PF00595.24 CCF51076.1 - 0.054 13.8 0.0 0.51 10.7 0.1 2.3 2 0 0 2 2 2 0 PDZ domain PDZ_2 PF13180.6 CCF51076.1 - 0.098 13.0 0.1 0.33 11.3 0.0 2.0 2 0 0 2 2 1 0 PDZ domain ATPgrasp_N PF18130.1 CCF51076.1 - 0.13 12.9 0.0 0.26 11.9 0.0 1.5 1 0 0 1 1 1 0 ATP-grasp N-terminal domain XdhC_C PF13478.6 CCF51076.1 - 0.18 12.3 0.0 0.42 11.1 0.0 1.6 2 0 0 2 2 2 0 XdhC Rossmann domain Far-17a_AIG1 PF04750.14 CCF51077.1 - 4.6e-36 124.0 1.1 5.4e-36 123.8 1.1 1.0 1 0 0 1 1 1 1 FAR-17a/AIG1-like protein Voltage_CLC PF00654.20 CCF51077.1 - 0.0043 16.3 0.0 0.0043 16.3 0.0 1.6 2 0 0 2 2 2 1 Voltage gated chloride channel zf-CCHC_6 PF15288.6 CCF51078.1 - 0.062 13.1 2.2 0.16 11.9 2.2 1.6 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC PF00098.23 CCF51078.1 - 0.64 10.2 4.1 1.4 9.2 4.1 1.6 1 0 0 1 1 1 0 Zinc knuckle RVT_2 PF07727.14 CCF51079.1 - 3.5e-46 157.8 1.1 2.1e-38 132.3 0.3 2.2 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) Sulfatase PF00884.23 CCF51080.1 - 3.7e-55 187.5 0.0 4.8e-55 187.1 0.0 1.1 1 0 0 1 1 1 1 Sulfatase Choline_sulf_C PF12411.8 CCF51080.1 - 1.6e-24 85.4 1.3 3.5e-24 84.3 1.3 1.6 1 0 0 1 1 1 1 Choline sulfatase enzyme C terminal Phosphodiest PF01663.22 CCF51080.1 - 1.1e-08 35.2 0.0 0.00023 20.9 0.0 2.3 2 0 0 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase_C PF14707.6 CCF51080.1 - 0.0042 17.8 0.3 0.015 16.0 0.2 1.9 1 1 0 1 1 1 1 C-terminal region of aryl-sulfatase DUF229 PF02995.17 CCF51080.1 - 0.0057 15.3 0.0 0.0085 14.8 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF229) DUF4994 PF16385.5 CCF51080.1 - 0.0096 15.8 0.0 2.1 8.3 0.0 2.5 1 1 1 2 2 2 2 Domain of unknown function TatD_DNase PF01026.21 CCF51081.1 - 3.2e-33 115.2 0.0 4e-33 114.9 0.0 1.1 1 0 0 1 1 1 1 TatD related DNase RRM_1 PF00076.22 CCF51082.1 - 6.5e-13 48.3 0.0 9.9e-08 31.7 0.0 2.8 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CCF51082.1 - 0.00021 21.3 0.0 0.00048 20.2 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif Pkinase PF00069.25 CCF51083.1 - 3.9e-65 219.8 0.0 5.3e-65 219.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF51083.1 - 1.3e-28 100.0 0.0 1.8e-28 99.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.24 CCF51083.1 - 1.1e-14 54.9 3.5 1.6e-13 51.2 0.2 3.0 2 1 0 2 2 2 1 Protein kinase C terminal domain C2 PF00168.30 CCF51083.1 - 2.3e-09 37.4 0.0 3.8e-08 33.5 0.0 2.4 1 1 0 1 1 1 1 C2 domain Kinase-like PF14531.6 CCF51083.1 - 2e-07 30.6 0.0 1.5e-06 27.7 0.0 2.0 2 0 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 CCF51083.1 - 0.00095 18.2 0.1 0.0026 16.8 0.1 1.7 1 1 0 1 1 1 1 Haspin like kinase domain FTA2 PF13095.6 CCF51083.1 - 0.0056 16.3 0.1 0.65 9.6 0.1 2.4 2 0 0 2 2 2 1 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 CCF51083.1 - 0.06 13.3 0.0 0.11 12.4 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Hamartin PF04388.12 CCF51083.1 - 0.83 8.2 12.9 1.1 7.8 12.9 1.3 1 0 0 1 1 1 0 Hamartin protein Macoilin PF09726.9 CCF51083.1 - 1.3 7.5 11.0 2.1 6.8 11.0 1.3 1 0 0 1 1 1 0 Macoilin family PorA PF11271.8 CCF51084.1 - 0.13 11.5 5.2 0.23 10.7 5.2 1.3 1 0 0 1 1 1 0 Porin PorA SGS PF05002.15 CCF51085.1 - 7.8e-33 112.4 2.8 1.3e-32 111.7 2.8 1.4 1 0 0 1 1 1 1 SGS domain CS PF04969.16 CCF51085.1 - 8.7e-15 55.5 0.1 1.4e-14 54.9 0.1 1.3 1 0 0 1 1 1 1 CS domain TT_ORF2 PF02957.15 CCF51085.1 - 0.025 15.5 0.6 0.045 14.7 0.6 1.4 1 0 0 1 1 1 0 TT viral ORF2 P_C PF06640.11 CCF51085.1 - 0.025 14.7 5.8 0.025 14.7 5.8 1.7 2 1 0 2 2 2 0 P protein C-terminus Elf1 PF05129.13 CCF51085.1 - 0.046 13.8 0.0 0.12 12.5 0.0 1.6 1 0 0 1 1 1 0 Transcription elongation factor Elf1 like Alg6_Alg8 PF03155.15 CCF51086.1 - 7.2e-155 516.6 26.3 1.3e-150 502.6 22.5 2.0 2 0 0 2 2 2 2 ALG6, ALG8 glycosyltransferase family DUF3425 PF11905.8 CCF51086.1 - 0.077 13.0 0.5 0.15 12.1 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3425) PUF PF00806.19 CCF51087.1 - 7.4e-64 208.0 5.3 3.7e-08 32.6 0.0 8.4 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat LOB PF03195.14 CCF51087.1 - 0.021 15.4 2.1 1.6 9.3 0.2 3.0 4 0 0 4 4 4 0 Lateral organ boundaries (LOB) domain START PF01852.19 CCF51088.1 - 4.2e-05 23.1 0.0 8.9e-05 22.0 0.0 1.4 1 0 0 1 1 1 1 START domain Phosducin PF02114.16 CCF51089.1 - 3.7e-13 49.0 0.1 7.3e-09 34.9 0.0 2.4 2 1 0 2 2 2 2 Phosducin Ribosomal_60s PF00428.19 CCF51089.1 - 0.038 14.6 1.2 0.11 13.1 1.2 1.7 1 0 0 1 1 1 0 60s Acidic ribosomal protein Thioredoxin PF00085.20 CCF51089.1 - 0.04 13.9 0.0 0.13 12.3 0.0 1.8 1 0 0 1 1 1 0 Thioredoxin GOLD_2 PF13897.6 CCF51089.1 - 0.44 11.1 6.0 0.85 10.1 0.1 2.3 2 0 0 2 2 2 0 Golgi-dynamics membrane-trafficking GST_N_3 PF13417.6 CCF51090.1 - 4.1e-08 33.5 0.0 7e-08 32.8 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 CCF51090.1 - 9.6e-08 32.1 0.0 1.8e-07 31.2 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 CCF51090.1 - 2.2e-05 24.7 0.0 3.6e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 CCF51090.1 - 6e-05 23.0 0.0 0.00011 22.2 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 CCF51090.1 - 0.0002 21.6 0.0 0.00045 20.5 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 CCF51090.1 - 0.0014 18.8 0.0 0.0045 17.2 0.0 1.8 2 1 0 2 2 2 1 Glutathione S-transferase, C-terminal domain 5_nucleotid_C PF02872.18 CCF51091.1 - 0.018 15.2 0.0 0.037 14.3 0.0 1.4 1 0 0 1 1 1 0 5'-nucleotidase, C-terminal domain PHINT_rpt PF14882.6 CCF51091.1 - 1.5 9.1 4.2 2.4 8.5 0.1 2.8 3 0 0 3 3 3 0 Phage-integrase repeat unit Sde2_N_Ubi PF13019.6 CCF51092.1 - 2.3e-40 138.1 0.1 2.3e-40 138.1 0.1 2.1 3 0 0 3 3 3 1 Silencing defective 2 N-terminal ubiquitin domain Motilin_assoc PF04643.12 CCF51092.1 - 0.14 12.0 0.4 0.26 11.2 0.4 1.4 1 0 0 1 1 1 0 Motilin/ghrelin-associated peptide Lactamase_B_6 PF16661.5 CCF51093.1 - 0.015 14.8 0.0 0.037 13.5 0.0 1.6 1 1 0 1 1 1 0 Metallo-beta-lactamase superfamily domain Lactamase_B_2 PF12706.7 CCF51093.1 - 0.022 14.3 1.2 0.091 12.3 1.2 2.0 1 1 0 1 1 1 0 Beta-lactamase superfamily domain DRMBL PF07522.14 CCF51093.1 - 0.11 12.7 0.0 0.9 9.7 0.0 2.4 2 0 0 2 2 2 0 DNA repair metallo-beta-lactamase zf-RING_2 PF13639.6 CCF51094.1 - 1.3e-06 28.6 7.0 1.3e-06 28.6 7.0 1.9 2 0 0 2 2 2 1 Ring finger domain zf-rbx1 PF12678.7 CCF51094.1 - 0.0027 17.9 5.6 0.0027 17.9 5.6 1.9 2 0 0 2 2 2 1 RING-H2 zinc finger domain FANCL_C PF11793.8 CCF51094.1 - 0.0044 17.2 3.1 0.012 15.8 3.1 1.7 1 0 0 1 1 1 1 FANCL C-terminal domain zf-ANAPC11 PF12861.7 CCF51094.1 - 0.0052 16.8 1.6 0.0052 16.8 1.6 1.8 2 0 0 2 2 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger C1_1 PF00130.22 CCF51094.1 - 0.029 14.2 0.8 0.057 13.3 0.8 1.5 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-C3HC4 PF00097.25 CCF51094.1 - 0.044 13.7 7.6 0.1 12.5 7.6 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) RINGv PF12906.7 CCF51094.1 - 0.25 11.5 9.0 0.15 12.2 5.2 2.4 2 0 0 2 2 2 0 RING-variant domain ANAPC15 PF15243.6 CCF51094.1 - 0.26 11.7 6.8 0.91 10.0 6.8 1.9 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 15 zf-C3HC4_2 PF13923.6 CCF51094.1 - 0.33 10.8 7.4 0.78 9.6 7.4 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) BUD22 PF09073.10 CCF51094.1 - 0.33 10.2 17.8 0.21 10.9 6.6 2.3 2 0 0 2 2 2 0 BUD22 zf-RING-like PF08746.11 CCF51094.1 - 0.38 11.1 5.0 0.99 9.8 5.0 1.8 1 0 0 1 1 1 0 RING-like domain Sporozoite_P67 PF05642.11 CCF51094.1 - 0.51 8.4 6.0 0.87 7.6 6.0 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Zn_ribbon_17 PF17120.5 CCF51094.1 - 1.2 8.8 3.0 2.9 7.6 3.0 1.6 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type DNA_pol_phi PF04931.13 CCF51094.1 - 1.8 6.6 19.7 0.0051 15.0 8.5 2.3 2 0 0 2 2 2 0 DNA polymerase phi zf-RING_4 PF14570.6 CCF51094.1 - 2.2 8.2 5.1 4.3 7.2 5.1 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Ric8 PF10165.9 CCF51094.1 - 6.1 5.8 9.0 3.9 6.4 0.5 3.7 3 2 0 3 3 3 0 Guanine nucleotide exchange factor synembryn TFIIS_M PF07500.14 CCF51095.1 - 1.2e-25 90.2 4.8 1.2e-25 90.2 4.8 2.0 2 0 0 2 2 2 1 Transcription factor S-II (TFIIS), central domain PHD PF00628.29 CCF51095.1 - 5.7e-12 45.3 9.2 9.7e-12 44.6 9.2 1.4 1 0 0 1 1 1 1 PHD-finger SPOC PF07744.13 CCF51095.1 - 3.6e-07 30.2 0.0 8.5e-07 29.0 0.0 1.6 1 0 0 1 1 1 1 SPOC domain PHD_2 PF13831.6 CCF51095.1 - 0.15 11.6 2.9 0.26 10.9 2.9 1.4 1 0 0 1 1 1 0 PHD-finger Porin_3 PF01459.22 CCF51096.1 - 3.8e-82 275.8 2.7 4.5e-82 275.5 2.7 1.0 1 0 0 1 1 1 1 Eukaryotic porin Fcf1 PF04900.12 CCF51097.1 - 2.5e-36 124.0 1.1 4.3e-36 123.3 1.1 1.4 1 0 0 1 1 1 1 Fcf1 PIN_9 PF18477.1 CCF51097.1 - 5e-12 46.2 0.0 1.8e-11 44.4 0.0 1.8 2 0 0 2 2 2 1 PIN like domain Imm-NTF2 PF15655.6 CCF51097.1 - 0.09 13.1 0.0 0.17 12.2 0.0 1.4 1 0 0 1 1 1 0 NTF2 fold immunity protein Tetraspanin PF00335.20 CCF51098.1 - 0.65 9.7 4.6 0.14 11.9 0.9 1.7 2 0 0 2 2 2 0 Tetraspanin family Peptidase_M22 PF00814.25 CCF51099.1 - 2.2e-75 253.9 0.0 2.7e-75 253.6 0.0 1.1 1 0 0 1 1 1 1 Glycoprotease family Exo_endo_phos PF03372.23 CCF51100.1 - 7e-09 35.5 0.1 1.1e-08 34.9 0.1 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family zf-GRF PF06839.12 CCF51100.1 - 1.5e-08 34.6 2.4 2.5e-06 27.5 0.3 2.6 2 0 0 2 2 2 2 GRF zinc finger Exo_endo_phos_2 PF14529.6 CCF51100.1 - 0.028 14.3 0.1 9.4 6.1 0.0 3.0 3 0 0 3 3 3 0 Endonuclease-reverse transcriptase SCA7 PF08313.12 CCF51101.1 - 2.8e-30 104.0 0.1 5.9e-30 103.0 0.1 1.5 1 0 0 1 1 1 1 SCA7, zinc-binding domain BRF1 PF07741.13 CCF51101.1 - 0.078 13.3 3.1 0.55 10.6 0.3 2.3 2 0 0 2 2 2 0 Brf1-like TBP-binding domain DASH_Dad2 PF08654.10 CCF51102.1 - 1.2e-25 89.8 0.0 1.6e-25 89.4 0.0 1.1 1 0 0 1 1 1 1 DASH complex subunit Dad2 DUF3348 PF11828.8 CCF51102.1 - 0.056 13.1 0.0 0.091 12.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3348) ATP-synt_ab PF00006.25 CCF51103.1 - 4.4e-106 353.3 0.0 6.4e-106 352.8 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_Xtn PF16886.5 CCF51103.1 - 4.5e-42 142.7 0.0 8e-42 141.9 0.0 1.4 1 0 0 1 1 1 1 ATPsynthase alpha/beta subunit N-term extension ATP-synt_ab_N PF02874.23 CCF51103.1 - 1.8e-14 54.0 3.5 4e-14 52.9 3.5 1.6 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain AAA PF00004.29 CCF51104.1 - 7.1e-42 143.0 0.0 2.4e-41 141.3 0.0 1.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 CCF51104.1 - 1.1e-06 28.3 0.1 2.7e-06 27.1 0.1 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 CCF51104.1 - 3.1e-05 24.0 0.1 0.00011 22.2 0.1 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 CCF51104.1 - 9.2e-05 22.7 0.0 0.0056 17.0 0.0 2.4 1 1 1 2 2 2 1 AAA domain AAA_16 PF13191.6 CCF51104.1 - 0.00013 22.4 0.3 0.0028 18.1 0.0 2.4 2 1 0 3 3 2 1 AAA ATPase domain AAA_2 PF07724.14 CCF51104.1 - 0.00021 21.5 0.0 0.00075 19.7 0.0 2.0 2 0 0 2 2 1 1 AAA domain (Cdc48 subfamily) DUF815 PF05673.13 CCF51104.1 - 0.00084 18.6 0.0 0.0014 17.8 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) RuvB_N PF05496.12 CCF51104.1 - 0.0034 17.1 0.0 0.0071 16.1 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_7 PF12775.7 CCF51104.1 - 0.013 15.0 0.0 0.03 13.8 0.0 1.6 1 1 0 1 1 1 0 P-loop containing dynein motor region AAA_28 PF13521.6 CCF51104.1 - 0.017 15.4 0.0 0.03 14.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 CCF51104.1 - 0.023 14.4 0.1 0.18 11.5 0.0 2.3 2 1 0 2 2 2 0 AAA domain AAA_33 PF13671.6 CCF51104.1 - 0.024 14.8 0.0 0.045 13.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_3 PF07726.11 CCF51104.1 - 0.043 13.7 0.0 0.077 12.9 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) ATPase_2 PF01637.18 CCF51104.1 - 0.051 13.5 0.0 7 6.5 0.0 2.4 1 1 1 2 2 2 0 ATPase domain predominantly from Archaea RNA_helicase PF00910.22 CCF51104.1 - 0.051 14.0 0.0 0.11 12.9 0.0 1.5 1 0 0 1 1 1 0 RNA helicase TIP49 PF06068.13 CCF51104.1 - 0.058 12.6 0.0 0.11 11.7 0.0 1.3 1 0 0 1 1 1 0 TIP49 P-loop domain Mg_chelatase PF01078.21 CCF51104.1 - 0.069 12.5 0.0 0.14 11.5 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 CCF51104.1 - 0.069 13.7 0.0 0.15 12.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain Sigma54_activ_2 PF14532.6 CCF51104.1 - 0.087 12.9 0.0 0.18 11.9 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain Sigma54_activat PF00158.26 CCF51104.1 - 0.11 12.2 0.0 0.26 11.0 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_14 PF13173.6 CCF51104.1 - 0.12 12.4 0.0 0.29 11.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 CCF51104.1 - 0.14 11.8 0.0 0.26 11.0 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein DUF4187 PF13821.6 CCF51105.1 - 3.3e-20 71.6 5.0 8.4e-20 70.3 5.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4187) G-patch PF01585.23 CCF51105.1 - 0.00013 21.7 0.2 0.00032 20.5 0.2 1.6 1 0 0 1 1 1 1 G-patch domain CDP-OH_P_transf PF01066.21 CCF51106.1 - 1.2e-12 48.4 0.8 1.2e-12 48.4 0.8 2.0 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase ORC_WH_C PF18137.1 CCF51107.1 - 3.2e-27 95.3 1.7 5.8e-27 94.5 0.1 2.3 2 1 0 2 2 2 1 Origin recognition complex winged helix C-terminal ORC3_N PF07034.11 CCF51107.1 - 2.4e-13 49.9 0.0 2.4e-06 26.9 0.0 4.3 4 1 0 4 4 4 2 Origin recognition complex (ORC) subunit 3 N-terminus DUF3069 PF11269.8 CCF51107.1 - 0.17 12.1 3.9 0.19 12.0 1.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3069) DUF2205 PF10224.9 CCF51109.1 - 8.4e-12 44.9 0.3 1.1e-11 44.5 0.3 1.1 1 0 0 1 1 1 1 Short coiled-coil protein YabA PF06156.13 CCF51109.1 - 0.014 16.0 0.4 0.017 15.8 0.4 1.1 1 0 0 1 1 1 0 Initiation control protein YabA Latarcin PF10279.9 CCF51109.1 - 0.054 13.9 0.4 0.064 13.7 0.4 1.2 1 0 0 1 1 1 0 Latarcin precursor LPP20 PF02169.16 CCF51109.1 - 0.091 13.1 0.2 0.14 12.5 0.2 1.4 1 1 0 1 1 1 0 LPP20 lipoprotein CBM_21 PF03370.13 CCF51110.1 - 3.4e-29 101.3 0.1 5.7e-29 100.6 0.1 1.3 1 0 0 1 1 1 1 Carbohydrate/starch-binding module (family 21) CBM53 PF16760.5 CCF51110.1 - 6e-07 30.0 0.4 1.3e-06 28.9 0.4 1.6 1 0 0 1 1 1 1 Starch/carbohydrate-binding module (family 53) DIRP PF06584.13 CCF51110.1 - 0.23 11.6 0.8 15 5.8 0.1 2.4 2 0 0 2 2 2 0 DIRP FAD_binding_3 PF01494.19 CCF51111.1 - 1.6e-56 192.0 0.0 1.5e-55 188.8 0.0 2.3 1 1 0 1 1 1 1 FAD binding domain Phe_hydrox_dim PF07976.12 CCF51111.1 - 1.4e-18 67.5 0.0 3.8e-18 66.1 0.0 1.7 2 0 0 2 2 2 1 Phenol hydroxylase, C-terminal dimerisation domain NAD_binding_8 PF13450.6 CCF51111.1 - 8.8e-06 25.9 0.0 3e-05 24.2 0.0 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CCF51111.1 - 0.00015 21.5 0.0 0.00031 20.4 0.0 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CCF51111.1 - 0.00016 21.1 0.0 0.00027 20.2 0.0 1.5 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CCF51111.1 - 0.00021 20.2 0.0 0.00033 19.5 0.0 1.3 1 0 0 1 1 1 1 HI0933-like protein Thi4 PF01946.17 CCF51111.1 - 0.0012 18.1 0.0 0.002 17.4 0.0 1.2 1 0 0 1 1 1 1 Thi4 family FAD_binding_2 PF00890.24 CCF51111.1 - 0.0021 17.2 0.1 0.0045 16.1 0.1 1.5 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_3 PF13738.6 CCF51111.1 - 0.0051 16.1 0.1 0.014 14.7 0.0 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 CCF51111.1 - 0.008 15.3 0.1 0.012 14.7 0.1 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein Pyr_redox PF00070.27 CCF51111.1 - 0.02 15.4 0.0 0.04 14.5 0.0 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CCF51111.1 - 0.029 14.4 0.0 0.054 13.5 0.0 1.5 1 0 0 1 1 1 0 FAD-NAD(P)-binding DUF1580 PF07618.11 CCF51111.1 - 0.053 13.1 0.1 0.15 11.7 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1580) Trp_halogenase PF04820.14 CCF51111.1 - 0.073 11.9 0.0 0.12 11.1 0.0 1.3 1 0 0 1 1 1 0 Tryptophan halogenase ApbA PF02558.16 CCF51111.1 - 0.11 12.1 0.0 0.44 10.2 0.0 1.9 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA UDPG_MGDP_dh_N PF03721.14 CCF51111.1 - 0.2 11.2 0.0 0.43 10.1 0.0 1.5 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain SE PF08491.10 CCF51111.1 - 0.24 10.4 0.0 7.2 5.6 0.0 2.1 2 0 0 2 2 2 0 Squalene epoxidase rve PF00665.26 CCF51114.1 - 3.1e-09 37.1 0.1 5.1e-09 36.4 0.1 1.4 1 0 0 1 1 1 1 Integrase core domain RVT_2 PF07727.14 CCF51115.1 - 2.6e-23 82.9 0.1 4.4e-19 69.1 0.0 2.1 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) MitMem_reg PF13012.6 CCF51116.1 - 9e-23 80.8 1.8 1.4e-22 80.2 1.1 1.7 2 0 0 2 2 2 1 Maintenance of mitochondrial structure and function JAB PF01398.21 CCF51116.1 - 1.6e-15 57.1 0.0 2.3e-14 53.4 0.0 2.2 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease PI3K_P85_iSH2 PF16454.5 CCF51117.1 - 0.21 11.2 1.6 0.39 10.3 1.6 1.4 1 0 0 1 1 1 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain TolA_bind_tri PF16331.5 CCF51117.1 - 1.4 9.0 7.3 1.3 9.1 5.2 2.1 1 1 1 2 2 2 0 TolA binding protein trimerisation TMF_TATA_bd PF12325.8 CCF51117.1 - 1.6 9.0 6.9 3.7 7.8 6.9 1.5 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding Senescence PF06911.12 CCF51118.1 - 2.8e-49 167.9 6.7 2.8e-49 167.9 6.7 1.5 2 0 0 2 2 2 1 Senescence-associated protein Laminin_G_1 PF00054.23 CCF51118.1 - 0.03 14.6 0.0 0.086 13.1 0.0 1.7 1 0 0 1 1 1 0 Laminin G domain DUF1691 PF07950.11 CCF51119.1 - 1.8e-06 28.6 6.1 0.0047 17.6 0.1 3.2 2 1 1 3 3 3 2 Protein of unknown function (DUF1691) RhoGAP PF00620.27 CCF51120.1 - 1.9e-37 128.4 0.0 3.6e-37 127.5 0.0 1.4 1 0 0 1 1 1 1 RhoGAP domain RVT_2 PF07727.14 CCF51121.1 - 2.4e-31 109.2 0.0 4.1e-28 98.7 0.1 2.2 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) RNase_H PF00075.24 CCF51122.1 - 0.0052 17.0 0.0 0.013 15.7 0.0 1.7 1 1 0 1 1 1 1 RNase H UQ_con PF00179.26 CCF51123.1 - 1.9e-44 150.7 0.0 2.1e-44 150.6 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme FAD_binding_6 PF00970.24 CCF51124.1 - 1.6e-33 115.0 0.1 2.7e-33 114.2 0.1 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.21 CCF51124.1 - 2.4e-29 102.2 0.0 3.7e-29 101.5 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.12 CCF51124.1 - 1.2e-07 31.9 0.0 1.5e-05 25.2 0.0 2.2 2 0 0 2 2 2 2 Ferric reductase NAD binding domain FAD_binding_9 PF08021.11 CCF51124.1 - 0.0053 17.0 0.0 0.018 15.3 0.0 1.9 2 0 0 2 2 2 1 Siderophore-interacting FAD-binding domain TOM13 PF08219.11 CCF51124.1 - 0.011 15.7 0.1 0.027 14.4 0.1 1.6 1 0 0 1 1 1 0 Outer membrane protein TOM13 Nup160 PF11715.8 CCF51125.1 - 2e-135 452.5 0.0 2.9e-135 452.0 0.0 1.2 1 0 0 1 1 1 1 Nucleoporin Nup120/160 Peptidase_M20 PF01546.28 CCF51126.1 - 5.5e-29 101.4 0.0 9.1e-29 100.6 0.0 1.4 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 CCF51126.1 - 7.4e-14 51.6 0.0 1.9e-13 50.3 0.0 1.7 1 1 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 CCF51126.1 - 0.066 12.9 0.0 0.15 11.7 0.0 1.6 1 0 0 1 1 1 0 Peptidase family M28 Herpes_U5 PF05999.11 CCF51127.1 - 0.2 10.4 0.1 0.28 9.9 0.1 1.1 1 0 0 1 1 1 0 Herpesvirus U5-like family Mitofilin PF09731.9 CCF51128.1 - 7.8e-163 543.6 28.6 9e-163 543.4 28.6 1.0 1 0 0 1 1 1 1 Mitochondrial inner membrane protein Cas_DxTHG PF09455.10 CCF51128.1 - 0.07 12.7 11.0 0.065 12.8 8.6 2.0 2 0 0 2 2 2 0 CRISPR-associated (Cas) DxTHG family Apolipoprotein PF01442.18 CCF51128.1 - 6.4 6.6 41.4 0.92 9.4 7.2 4.1 3 1 1 4 4 4 0 Apolipoprotein A1/A4/E domain 2Fe-2S_thioredx PF01257.19 CCF51129.1 - 9.9e-62 207.1 0.1 1.3e-61 206.7 0.1 1.1 1 0 0 1 1 1 1 Thioredoxin-like [2Fe-2S] ferredoxin Fer4 PF00037.27 CCF51130.1 - 3.1e-14 52.1 16.4 2.2e-08 33.6 4.5 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_7 PF12838.7 CCF51130.1 - 6.8e-13 49.0 10.4 1.1e-12 48.3 10.4 1.4 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_16 PF13484.6 CCF51130.1 - 3.2e-10 40.8 8.6 2.6e-05 25.1 0.8 2.3 2 0 0 2 2 2 2 4Fe-4S double cluster binding domain Fer4_21 PF14697.6 CCF51130.1 - 2.6e-09 37.1 6.7 0.00018 21.6 0.6 2.2 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_10 PF13237.6 CCF51130.1 - 1.3e-08 34.8 21.9 4.7e-06 26.6 12.7 2.1 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_9 PF13187.6 CCF51130.1 - 1.5e-08 34.6 10.2 2.6e-08 33.9 10.2 1.4 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_8 PF13183.6 CCF51130.1 - 1.7e-08 34.8 3.1 0.00023 21.5 0.2 2.3 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_6 PF12837.7 CCF51130.1 - 6.1e-07 29.3 17.8 0.00049 20.1 5.4 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_2 PF12797.7 CCF51130.1 - 2.1e-06 27.5 12.5 0.0034 17.4 2.0 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_4 PF12800.7 CCF51130.1 - 1.6e-05 25.0 11.8 0.00062 20.1 2.5 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_17 PF13534.6 CCF51130.1 - 0.00019 21.9 10.9 0.032 14.8 12.1 2.4 1 1 2 3 3 3 3 4Fe-4S dicluster domain Fer4_13 PF13370.6 CCF51130.1 - 0.00068 20.1 10.4 0.11 13.1 0.3 2.6 2 0 0 2 2 2 2 4Fe-4S single cluster domain of Ferredoxin I c-SKI_SMAD_bind PF08782.10 CCF51130.1 - 0.023 14.9 5.4 1.5 9.1 0.3 2.2 1 1 1 2 2 2 0 c-SKI Smad4 binding domain Fer4_18 PF13746.6 CCF51130.1 - 0.085 13.1 9.0 16 5.7 9.0 2.3 1 1 0 1 1 1 0 4Fe-4S dicluster domain Fer4_3 PF12798.7 CCF51130.1 - 0.31 12.1 16.3 0.42 11.6 4.1 2.3 2 0 0 2 2 2 0 4Fe-4S binding domain ETF_QO PF05187.13 CCF51130.1 - 0.53 10.4 6.2 2.7 8.2 0.8 2.4 1 1 1 2 2 2 0 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S Fer4_22 PF17179.4 CCF51130.1 - 0.55 11.1 11.5 2.5 9.0 1.5 2.3 1 1 2 3 3 3 0 4Fe-4S dicluster domain EPF PF17181.4 CCF51130.1 - 2 8.5 6.9 1.1 9.3 0.8 2.4 2 0 0 2 2 2 0 Epidermal patterning factor proteins Ydr279_N PF17745.1 CCF51131.1 - 2.9e-07 30.6 0.0 5.8e-07 29.7 0.0 1.5 1 0 0 1 1 1 1 Ydr279p protein triple barrel domain RNase_H2-Ydr279 PF09468.10 CCF51131.1 - 5.9e-07 29.8 0.0 1.1e-06 28.9 0.0 1.4 1 0 0 1 1 1 1 Ydr279p protein family (RNase H2 complex component) wHTH domain ExsD PF16806.5 CCF51131.1 - 0.07 13.0 0.1 0.11 12.4 0.1 1.2 1 0 0 1 1 1 0 Antiactivator protein ExsD VCBS PF13517.6 CCF51132.1 - 4e-18 65.7 21.6 6.9e-07 29.8 1.6 6.2 5 1 1 6 6 6 6 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 CCF51132.1 - 2.1e-11 43.7 15.6 0.00074 19.6 0.0 6.7 6 0 0 6 6 6 6 FG-GAP repeat TcdB_toxin_midN PF12256.8 CCF51132.1 - 0.035 13.5 3.1 12 5.2 0.0 4.3 5 1 1 6 6 6 0 Insecticide toxin TcdB middle/N-terminal region V_ATPase_I PF01496.19 CCF51133.1 - 1.2e-302 1005.9 0.0 1.4e-302 1005.7 0.0 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family TPR_1 PF00515.28 CCF51134.1 - 3.4e-26 89.9 10.1 1.8e-05 24.3 0.0 8.0 9 0 0 9 9 8 5 Tetratricopeptide repeat TPR_8 PF13181.6 CCF51134.1 - 3e-24 83.2 1.4 2.3e-06 27.3 0.0 8.0 8 0 0 8 8 8 4 Tetratricopeptide repeat ANAPC8 PF04049.13 CCF51134.1 - 1.2e-19 70.8 0.0 1.9e-11 44.2 0.0 2.8 2 0 0 2 2 2 2 Anaphase promoting complex subunit 8 / Cdc23 TPR_2 PF07719.17 CCF51134.1 - 4.9e-18 63.7 19.0 0.00089 19.2 0.1 8.9 10 0 0 10 10 10 4 Tetratricopeptide repeat TPR_16 PF13432.6 CCF51134.1 - 6.5e-13 49.1 11.7 7.3e-09 36.1 1.3 6.3 3 1 3 6 6 6 2 Tetratricopeptide repeat TPR_14 PF13428.6 CCF51134.1 - 6.9e-13 48.2 14.0 0.00039 21.0 0.1 8.8 4 2 5 9 9 9 4 Tetratricopeptide repeat ANAPC3 PF12895.7 CCF51134.1 - 1.6e-11 44.3 11.7 0.0032 17.6 0.1 4.0 2 1 1 3 3 3 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.6 CCF51134.1 - 4.8e-11 42.8 19.3 9.1e-05 22.7 0.4 7.5 5 2 0 6 6 6 2 Tetratricopeptide repeat TPR_19 PF14559.6 CCF51134.1 - 1.9e-09 37.9 4.0 0.13 12.8 0.3 6.1 4 1 2 6 6 6 2 Tetratricopeptide repeat TPR_17 PF13431.6 CCF51134.1 - 5.1e-09 35.9 1.8 0.092 13.2 0.2 7.0 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_7 PF13176.6 CCF51134.1 - 3e-08 33.1 11.7 1.1 9.5 0.0 6.5 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_9 PF13371.6 CCF51134.1 - 9.3e-08 32.1 19.3 0.0011 19.0 0.1 6.0 6 1 2 8 8 8 3 Tetratricopeptide repeat TPR_11 PF13414.6 CCF51134.1 - 1.4e-07 31.0 5.0 1.2e-05 24.8 1.2 3.1 3 0 0 3 3 3 2 TPR repeat TPR_15 PF13429.6 CCF51134.1 - 2.2e-06 27.1 4.9 0.2 10.8 0.0 4.2 3 1 2 5 5 5 2 Tetratricopeptide repeat TPR_6 PF13174.6 CCF51134.1 - 6.7e-05 23.3 12.3 0.47 11.2 0.3 7.5 9 0 0 9 9 7 1 Tetratricopeptide repeat TPR_10 PF13374.6 CCF51134.1 - 0.021 14.7 16.9 23 5.0 0.0 7.2 8 0 0 8 8 7 0 Tetratricopeptide repeat ST7 PF04184.12 CCF51134.1 - 0.088 11.3 0.0 0.13 10.7 0.0 1.2 1 0 0 1 1 1 0 ST7 protein Ribosomal_S6e PF01092.19 CCF51135.1 - 3.2e-56 188.7 0.0 6.7e-56 187.6 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein S6e Ribosomal_S13_N PF08069.12 CCF51136.1 - 3.3e-31 107.1 0.4 5.8e-31 106.3 0.4 1.4 1 0 0 1 1 1 1 Ribosomal S13/S15 N-terminal domain Ribosomal_S15 PF00312.22 CCF51136.1 - 1.3e-14 54.2 0.2 2.1e-14 53.5 0.2 1.3 1 0 0 1 1 1 1 Ribosomal protein S15 PAX PF00292.18 CCF51136.1 - 0.055 13.4 0.0 0.14 12.1 0.0 1.7 2 0 0 2 2 2 0 'Paired box' domain HTH_32 PF13565.6 CCF51136.1 - 0.057 14.0 0.0 0.13 12.9 0.0 1.6 1 0 0 1 1 1 0 Homeodomain-like domain Arrestin_N PF00339.29 CCF51137.1 - 0.018 15.1 0.0 0.59 10.2 0.0 2.5 2 0 0 2 2 2 0 Arrestin (or S-antigen), N-terminal domain LRR_4 PF12799.7 CCF51138.1 - 3.9e-05 23.9 10.4 0.7 10.4 0.0 6.6 5 4 3 8 8 8 4 Leucine Rich repeats (2 copies) Cdc6_C PF09079.11 CCF51138.1 - 0.14 12.1 0.1 2.5 8.1 0.0 2.7 2 0 0 2 2 2 0 CDC6, C terminal winged helix domain PPP4R2 PF09184.11 CCF51138.1 - 2.1 7.8 8.5 3.3 7.2 8.5 1.2 1 0 0 1 1 1 0 PPP4R2 Ysc84 PF04366.12 CCF51139.1 - 5.8e-41 139.2 0.1 2.5e-40 137.2 0.0 2.1 3 0 0 3 3 3 1 Las17-binding protein actin regulator SH3_1 PF00018.28 CCF51139.1 - 3.3e-14 52.2 0.1 6.2e-14 51.3 0.1 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 CCF51139.1 - 1.1e-12 47.6 0.0 2e-12 46.8 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 CCF51139.1 - 4.4e-10 39.1 0.0 1.3e-09 37.6 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain Glyco_hydro_9 PF00759.19 CCF51140.1 - 2.2e-105 353.4 15.0 2.7e-105 353.2 15.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 9 VSP PF03302.13 CCF51140.1 - 0.58 9.0 2.1 0.59 8.9 0.8 1.5 2 0 0 2 2 2 0 Giardia variant-specific surface protein Arf PF00025.21 CCF51141.1 - 4.5e-67 224.9 0.0 5.3e-67 224.6 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 CCF51141.1 - 2e-14 53.5 0.8 1.8e-09 37.3 0.1 2.3 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.10 CCF51141.1 - 2.6e-13 49.8 0.0 3.4e-13 49.4 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.13 CCF51141.1 - 4e-12 46.4 0.0 6.2e-12 45.8 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 CCF51141.1 - 3.6e-09 36.3 0.0 4.4e-09 36.0 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Ras PF00071.22 CCF51141.1 - 3.9e-09 36.3 0.0 4.6e-09 36.1 0.0 1.1 1 0 0 1 1 1 1 Ras family MMR_HSR1 PF01926.23 CCF51141.1 - 9.8e-09 35.3 0.0 1.9e-08 34.3 0.0 1.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 CCF51141.1 - 0.00018 21.1 0.0 0.0024 17.4 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 CCF51141.1 - 0.0042 16.6 0.0 0.012 15.1 0.0 1.9 1 1 0 1 1 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 CCF51141.1 - 0.018 15.0 0.0 1.1 9.1 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase TsaE PF02367.17 CCF51141.1 - 0.036 14.1 0.0 0.065 13.2 0.0 1.4 1 1 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE CdhD PF03599.16 CCF51141.1 - 0.041 12.6 0.0 0.051 12.3 0.0 1.2 1 0 0 1 1 1 0 CO dehydrogenase/acetyl-CoA synthase delta subunit cobW PF02492.19 CCF51141.1 - 0.046 13.3 0.0 2.7 7.5 0.0 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain XS PF03468.14 CCF51141.1 - 0.061 13.6 0.0 0.089 13.1 0.0 1.3 1 0 0 1 1 1 0 XS domain PIG-U PF06728.13 CCF51142.1 - 9.7e-87 291.5 19.6 3.5e-86 289.7 19.6 1.9 1 1 0 1 1 1 1 GPI transamidase subunit PIG-U 8TM_micro PF17028.5 CCF51142.1 - 0.094 12.4 5.5 0.18 11.5 5.5 1.4 1 0 0 1 1 1 0 8TM Microsporidial transmembrane domain DEAD PF00270.29 CCF51143.1 - 7.4e-38 130.1 0.0 6.9e-36 123.7 0.0 2.3 2 0 0 2 2 2 2 DEAD/DEAH box helicase Helicase_C PF00271.31 CCF51143.1 - 1.8e-20 73.3 0.2 5.9e-19 68.5 0.1 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ERCC3_RAD25_C PF16203.5 CCF51143.1 - 0.053 12.7 0.1 0.091 12.0 0.1 1.2 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase PutA_N PF18083.1 CCF51143.1 - 0.12 12.4 0.8 0.66 10.0 0.0 2.4 2 0 0 2 2 2 0 Proline utilization A N-terminal domain Adaptin_N PF01602.20 CCF51144.1 - 9.9e-151 502.8 10.6 1.2e-150 502.6 10.6 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptinC2 PF02883.20 CCF51144.1 - 3e-25 88.7 0.4 6e-25 87.7 0.4 1.5 1 0 0 1 1 1 1 Adaptin C-terminal domain Cnd1 PF12717.7 CCF51144.1 - 3.9e-10 40.0 8.2 5e-07 29.9 0.9 3.5 4 0 0 4 4 4 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 CCF51144.1 - 0.00011 22.5 3.1 0.99 9.8 0.1 5.3 6 2 2 8 8 8 2 HEAT repeats NPCBM_assoc PF10633.9 CCF51144.1 - 0.0029 17.8 0.5 0.0087 16.3 0.5 1.8 1 0 0 1 1 1 1 NPCBM-associated, NEW3 domain of alpha-galactosidase HEAT PF02985.22 CCF51144.1 - 0.011 15.9 0.5 1.1e+02 3.5 0.0 4.9 4 0 0 4 4 4 0 HEAT repeat Peptidase_M73 PF12389.8 CCF51144.1 - 0.016 15.0 0.3 0.036 13.9 0.1 1.6 2 0 0 2 2 2 0 Camelysin metallo-endopeptidase RIX1 PF08167.12 CCF51144.1 - 0.028 14.2 0.8 0.31 10.8 0.1 3.1 2 1 0 2 2 2 0 rRNA processing/ribosome biogenesis V-ATPase_H_C PF11698.8 CCF51144.1 - 0.64 10.1 2.9 5.7 7.1 0.1 3.4 2 1 1 3 3 3 0 V-ATPase subunit H TIP120 PF08623.10 CCF51144.1 - 2.9 7.6 7.9 7.5 6.3 0.2 4.2 3 2 1 4 4 4 0 TATA-binding protein interacting (TIP20) Hist_deacetyl PF00850.19 CCF51145.1 - 1.5e-81 274.2 0.0 2e-81 273.9 0.0 1.1 1 0 0 1 1 1 1 Histone deacetylase domain Nuc_sug_transp PF04142.15 CCF51146.1 - 3e-08 33.2 0.1 3e-08 33.2 0.1 1.5 2 0 0 2 2 2 1 Nucleotide-sugar transporter UAA PF08449.11 CCF51146.1 - 8.4e-08 31.8 8.9 1.7e-07 30.8 8.9 1.4 1 0 0 1 1 1 1 UAA transporter family TPT PF03151.16 CCF51146.1 - 9.9e-06 25.1 1.2 9.9e-06 25.1 1.2 2.1 2 0 0 2 2 2 1 Triose-phosphate Transporter family EamA PF00892.20 CCF51146.1 - 0.00055 20.1 29.4 0.0016 18.6 4.7 3.1 3 1 0 3 3 3 2 EamA-like transporter family CitMHS PF03600.16 CCF51146.1 - 7.7 5.6 11.8 25 3.9 11.8 1.8 1 1 0 1 1 1 0 Citrate transporter HECT PF00632.25 CCF51147.1 - 1.8e-95 320.0 0.0 2.3e-95 319.6 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) WW PF00397.26 CCF51147.1 - 6.2e-35 119.0 16.8 3.6e-12 46.1 2.6 3.8 3 0 0 3 3 3 3 WW domain C2 PF00168.30 CCF51147.1 - 1.2e-20 73.7 0.1 3.5e-20 72.2 0.1 1.8 1 0 0 1 1 1 1 C2 domain FliJ PF02050.16 CCF51149.1 - 0.014 15.6 1.7 0.014 15.6 1.7 2.3 2 0 0 2 2 2 0 Flagellar FliJ protein DUF1192 PF06698.11 CCF51149.1 - 0.025 14.6 0.2 0.55 10.3 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) TACC_C PF05010.14 CCF51149.1 - 0.047 13.5 1.3 0.047 13.5 1.3 2.1 3 0 0 3 3 3 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal CREPT PF16566.5 CCF51149.1 - 0.052 13.7 4.8 0.36 11.0 0.1 2.5 2 0 0 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour Spc7 PF08317.11 CCF51149.1 - 1.4 7.8 9.6 0.2 10.5 5.7 1.6 2 0 0 2 2 2 0 Spc7 kinetochore protein DUF4200 PF13863.6 CCF51149.1 - 1.6 9.1 10.3 4.6 7.7 3.2 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4200) Exonuc_VII_L PF02601.15 CCF51149.1 - 1.7 8.1 8.3 3.3 7.2 8.4 1.5 1 1 0 1 1 1 0 Exonuclease VII, large subunit Lectin_N PF03954.14 CCF51149.1 - 2.4 7.9 8.5 0.98 9.2 0.5 2.6 3 0 0 3 3 3 0 Hepatic lectin, N-terminal domain TMPIT PF07851.13 CCF51149.1 - 4.5 6.4 4.9 8.1 5.6 4.7 1.6 1 1 0 1 1 1 0 TMPIT-like protein Lebercilin PF15619.6 CCF51149.1 - 5.2 6.7 13.3 5.9 6.5 0.4 2.9 3 0 0 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease DUF16 PF01519.16 CCF51149.1 - 6.3 7.3 6.5 40 4.8 3.6 2.9 2 1 0 2 2 2 0 Protein of unknown function DUF16 Complex1_LYR PF05347.15 CCF51150.1 - 1.2e-05 25.2 0.2 3.7e-05 23.7 0.1 1.9 2 0 0 2 2 2 1 Complex 1 protein (LYR family) Ribosomal_L31 PF01197.18 CCF51150.1 - 0.011 16.0 0.0 0.024 14.9 0.0 1.6 1 0 0 1 1 1 0 Ribosomal protein L31 NDUF_C2 PF06374.11 CCF51151.1 - 0.075 13.2 0.0 0.08 13.1 0.0 1.2 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2) RNase_T PF00929.24 CCF51152.1 - 3.1e-11 44.1 0.0 1.3e-08 35.6 0.0 2.3 2 0 0 2 2 2 2 Exonuclease SAP PF02037.27 CCF51152.1 - 7.7e-09 35.1 4.2 8.5e-09 35.0 1.9 2.2 2 0 0 2 2 2 1 SAP domain HeH PF12949.7 CCF51152.1 - 0.015 15.0 0.1 0.037 13.7 0.1 1.7 1 0 0 1 1 1 0 HeH/LEM domain THDPS_M PF14789.6 CCF51152.1 - 0.07 13.2 0.0 0.22 11.6 0.0 1.9 1 0 0 1 1 1 0 Tetrahydrodipicolinate N-succinyltransferase middle UPF0561 PF10573.9 CCF51152.1 - 0.09 12.9 0.0 0.3 11.2 0.0 1.9 2 0 0 2 2 2 0 Uncharacterised protein family UPF0561 Torus PF16131.5 CCF51153.1 - 4.1e-08 33.9 0.1 8.9e-08 32.8 0.1 1.5 1 0 0 1 1 1 1 Torus domain RRM_1 PF00076.22 CCF51153.1 - 4.7e-06 26.3 0.0 8.3e-06 25.5 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf_CCCH_4 PF18345.1 CCF51153.1 - 1.2e-05 25.2 1.7 3.1e-05 23.9 1.7 1.7 1 0 0 1 1 1 1 Zinc finger domain zf-CCCH PF00642.24 CCF51153.1 - 4e-05 23.4 2.3 4e-05 23.4 2.3 2.1 2 0 0 2 2 2 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) FYVE PF01363.21 CCF51153.1 - 0.0064 16.6 1.3 0.0086 16.2 0.1 1.9 2 0 0 2 2 2 1 FYVE zinc finger zf-CCCH_4 PF18044.1 CCF51153.1 - 0.02 14.7 2.5 0.058 13.2 2.5 1.8 1 0 0 1 1 1 0 CCCH-type zinc finger DUF2256 PF10013.9 CCF51153.1 - 0.16 12.1 0.4 0.16 12.1 0.4 3.2 4 1 1 5 5 5 0 Uncharacterized protein conserved in bacteria (DUF2256) zf-CCCH_2 PF14608.6 CCF51153.1 - 6.6 7.4 6.3 1.2 9.7 2.3 2.0 2 0 0 2 2 2 0 RNA-binding, Nab2-type zinc finger AMPK1_CBM PF16561.5 CCF51154.1 - 4.1e-29 100.6 0.0 7.5e-29 99.8 0.0 1.4 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase AMPKBI PF04739.15 CCF51154.1 - 1e-28 99.4 0.8 3.9e-28 97.5 0.8 2.1 1 0 0 1 1 1 1 5'-AMP-activated protein kinase beta subunit, interaction domain MAT1 PF06391.13 CCF51155.1 - 1.8e-44 152.0 22.6 2.4e-44 151.6 22.6 1.1 1 0 0 1 1 1 1 CDK-activating kinase assembly factor MAT1 zf-C3HC4_5 PF17121.5 CCF51155.1 - 9.3e-21 73.5 7.2 1.4e-20 72.9 7.2 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 CCF51155.1 - 0.00015 21.5 7.9 0.00063 19.6 8.2 1.8 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CCF51155.1 - 0.00024 20.9 9.8 0.0018 18.1 10.1 2.0 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CCF51155.1 - 0.00058 19.8 7.0 0.002 18.0 7.1 1.8 1 1 1 2 2 2 1 zinc-RING finger domain zf-RING_2 PF13639.6 CCF51155.1 - 0.0012 19.1 6.2 0.0022 18.3 6.2 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_4 PF14570.6 CCF51155.1 - 0.0022 17.7 6.2 0.025 14.4 1.9 2.3 2 0 0 2 2 2 1 RING/Ubox like zinc-binding domain Rrn6 PF10214.9 CCF51155.1 - 0.0029 16.2 4.7 0.0033 16.0 4.7 1.1 1 0 0 1 1 1 1 RNA polymerase I-specific transcription-initiation factor zf-C3HC4_2 PF13923.6 CCF51155.1 - 0.0093 15.8 11.7 0.12 12.2 12.2 2.1 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 CCF51155.1 - 0.084 12.7 10.3 0.61 10.0 10.5 2.0 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 DZR PF12773.7 CCF51155.1 - 0.14 12.2 6.8 0.63 10.1 6.9 1.9 1 1 1 2 2 2 0 Double zinc ribbon zf-RING_UBOX PF13445.6 CCF51155.1 - 0.23 11.5 6.9 0.45 10.6 6.9 1.5 1 0 0 1 1 1 0 RING-type zinc-finger DNA_ligase_ZBD PF03119.16 CCF51155.1 - 0.23 11.5 1.9 1 9.4 0.1 2.6 2 0 0 2 2 2 0 NAD-dependent DNA ligase C4 zinc finger domain zf-rbx1 PF12678.7 CCF51155.1 - 0.29 11.5 2.7 0.55 10.5 2.7 1.5 1 0 0 1 1 1 0 RING-H2 zinc finger domain Zn-ribbon_8 PF09723.10 CCF51155.1 - 0.36 11.0 7.5 8 6.7 3.5 2.7 2 0 0 2 2 2 0 Zinc ribbon domain zf-ribbon_3 PF13248.6 CCF51155.1 - 0.49 9.9 4.9 4.2 6.9 0.8 2.5 2 0 0 2 2 2 0 zinc-ribbon domain Smg8_Smg9 PF10220.9 CCF51155.1 - 1.3 7.3 7.9 1.7 6.8 7.9 1.0 1 0 0 1 1 1 0 Smg8_Smg9 zinc_ribbon_2 PF13240.6 CCF51155.1 - 1.4 8.7 5.8 1.1 9.1 1.4 2.4 2 0 0 2 2 2 0 zinc-ribbon domain Presenilin PF01080.17 CCF51155.1 - 1.6 7.4 9.2 2 7.1 9.2 1.1 1 0 0 1 1 1 0 Presenilin zf_UBZ PF18439.1 CCF51155.1 - 1.6 8.4 4.0 1.1 8.9 0.1 2.3 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger CDC45 PF02724.14 CCF51155.1 - 3.3 5.9 20.4 4.7 5.4 20.4 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF3797 PF12677.7 CCF51155.1 - 3.9 7.5 6.7 3.2 7.7 0.9 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF3797) RR_TM4-6 PF06459.12 CCF51155.1 - 4.6 7.0 14.3 6.3 6.5 14.3 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 zf-UDP PF14569.6 CCF51155.1 - 6.3 7.0 8.2 19 5.5 0.7 2.5 1 1 1 2 2 2 0 Zinc-binding RING-finger RINGv PF12906.7 CCF51156.1 - 7.9e-10 38.7 6.9 1.4e-09 37.9 6.9 1.5 1 0 0 1 1 1 1 RING-variant domain DUF2116 PF09889.9 CCF51158.1 - 0.03 14.3 0.5 0.069 13.1 0.5 1.6 1 0 0 1 1 1 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) Uricase PF01014.18 CCF51160.1 - 1.1e-63 213.3 0.0 1.2e-33 116.2 0.2 2.1 2 0 0 2 2 2 2 Uricase GLTP PF08718.11 CCF51161.1 - 3.4e-49 167.0 0.0 5e-49 166.4 0.0 1.3 1 0 0 1 1 1 1 Glycolipid transfer protein (GLTP) F_bP_aldolase PF01116.20 CCF51162.1 - 5.9e-93 311.4 0.0 6.6e-93 311.2 0.0 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-II WD40 PF00400.32 CCF51163.1 - 6.8e-09 36.2 2.7 0.16 12.9 0.0 4.8 4 0 0 4 4 4 2 WD domain, G-beta repeat PQQ_3 PF13570.6 CCF51163.1 - 0.063 13.8 0.2 16 6.1 0.1 2.8 2 0 0 2 2 2 0 PQQ-like domain Dehydratase_SU PF02287.15 CCF51163.1 - 0.19 11.8 6.9 0.054 13.6 0.7 2.6 1 1 1 2 2 2 0 Dehydratase small subunit ABC1 PF03109.16 CCF51164.1 - 3.6e-22 78.7 0.0 1.3e-14 54.3 0.0 2.5 2 0 0 2 2 2 2 ABC1 family AdoMet_MTase PF07757.13 CCF51165.1 - 2e-33 115.1 0.0 3.1e-33 114.4 0.0 1.3 1 0 0 1 1 1 1 Predicted AdoMet-dependent methyltransferase Methyltransf_32 PF13679.6 CCF51165.1 - 5.6e-05 23.2 0.2 0.00083 19.4 0.2 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCF51165.1 - 0.031 14.1 0.0 0.055 13.3 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_25 PF13649.6 CCF51165.1 - 0.13 13.0 0.0 0.24 12.1 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.6 CCF51165.1 - 0.31 10.8 0.5 0.51 10.1 0.1 1.5 2 0 0 2 2 2 0 Methyltransferase domain Tom5 PF10642.9 CCF51166.1 - 2e-17 63.0 0.3 2.1e-17 62.8 0.3 1.0 1 0 0 1 1 1 1 Mitochondrial import receptor subunit or translocase VMA21 PF09446.10 CCF51166.1 - 0.057 13.5 0.0 0.066 13.3 0.0 1.1 1 0 0 1 1 1 0 VMA21-like domain S1 PF00575.23 CCF51167.1 - 1.1e-49 166.6 23.6 6.4e-10 39.2 1.7 9.9 10 0 0 10 10 10 8 S1 RNA binding domain Suf PF05843.14 CCF51167.1 - 1.4e-07 31.8 0.1 1.4e-07 31.8 0.1 4.6 2 2 3 5 5 5 2 Suppressor of forked protein (Suf) BUD22 PF09073.10 CCF51167.1 - 2.8e-05 23.6 22.2 2.8e-05 23.6 22.2 3.1 2 1 1 3 3 3 2 BUD22 TPR_16 PF13432.6 CCF51167.1 - 0.00023 21.7 0.2 2.5 8.8 0.0 4.6 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_14 PF13428.6 CCF51167.1 - 0.00066 20.3 1.6 4.7 8.3 0.0 4.9 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_19 PF14559.6 CCF51167.1 - 0.0013 19.2 0.0 0.2 12.2 0.0 3.4 2 1 0 3 3 3 1 Tetratricopeptide repeat TPR_15 PF13429.6 CCF51167.1 - 0.0058 15.9 3.0 0.019 14.2 0.8 2.4 2 1 0 2 2 2 1 Tetratricopeptide repeat tRNA_bind PF01588.20 CCF51167.1 - 0.018 15.2 1.4 0.058 13.5 0.8 2.2 2 0 0 2 2 2 0 Putative tRNA binding domain TPR_6 PF13174.6 CCF51167.1 - 0.11 13.2 0.1 3.9 8.3 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat MFS_1 PF07690.16 CCF51168.1 - 1.2e-40 139.6 35.9 1.6e-39 135.9 35.6 2.5 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF51168.1 - 2.1e-15 56.5 1.4 2.1e-15 56.5 1.4 3.0 4 0 0 4 4 4 2 Sugar (and other) transporter ANAPC10 PF03256.16 CCF51169.1 - 3.6e-48 163.7 0.0 4.8e-48 163.3 0.0 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex, subunit 10 (APC10) DNA_pol_phi PF04931.13 CCF51169.1 - 3.1 5.8 4.6 4.5 5.3 4.6 1.1 1 0 0 1 1 1 0 DNA polymerase phi zf-Tim10_DDP PF02953.15 CCF51170.1 - 1.7e-24 85.2 0.8 2.2e-24 84.9 0.8 1.2 1 0 0 1 1 1 1 Tim10/DDP family zinc finger Acyltransferase PF01553.21 CCF51171.1 - 2.4e-21 75.8 0.0 4.1e-21 75.0 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase Methyltransf_19 PF04672.12 CCF51171.1 - 0.18 11.3 0.0 0.68 9.4 0.0 1.8 2 0 0 2 2 2 0 S-adenosyl methyltransferase NAD_binding_1 PF00175.21 CCF51172.1 - 9.1e-06 26.3 0.0 0.0028 18.3 0.0 2.2 2 0 0 2 2 2 2 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 CCF51172.1 - 0.085 13.2 0.0 0.21 12.0 0.0 1.7 1 0 0 1 1 1 0 Oxidoreductase FAD-binding domain ISET-FN3_linker PF16625.5 CCF51173.1 - 3.9 8.1 6.1 22 5.7 0.9 2.8 2 0 0 2 2 2 0 Unstructured linking region I-set and fnIII on Brother of CDO DKCLD PF08068.12 CCF51174.1 - 1.9e-33 114.3 0.1 4.9e-32 109.8 0.2 2.6 2 0 0 2 2 2 1 DKCLD (NUC011) domain TruB_N PF01509.18 CCF51174.1 - 5.7e-24 85.2 0.3 6.2e-21 75.3 0.3 3.3 1 1 0 1 1 1 1 TruB family pseudouridylate synthase (N terminal domain) TruB_C_2 PF16198.5 CCF51174.1 - 5.9e-23 80.8 0.5 1.1e-22 79.9 0.5 1.5 1 0 0 1 1 1 1 tRNA pseudouridylate synthase B C-terminal domain PUA PF01472.20 CCF51174.1 - 8.7e-21 73.7 0.8 2.1e-20 72.5 0.8 1.7 1 0 0 1 1 1 1 PUA domain UPF0113 PF03657.13 CCF51174.1 - 0.00076 19.7 0.0 0.0019 18.4 0.0 1.7 1 0 0 1 1 1 1 UPF0113 PUA domain RNA_polI_A34 PF08208.11 CCF51174.1 - 0.43 10.7 27.0 0.68 10.0 27.0 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 RR_TM4-6 PF06459.12 CCF51174.1 - 8.8 6.1 17.3 12 5.6 17.3 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Ribosomal_L22e PF01776.17 CCF51175.1 - 1.1e-46 157.7 0.3 1.4e-46 157.3 0.3 1.0 1 0 0 1 1 1 1 Ribosomal L22e protein family GW PF13457.6 CCF51175.1 - 0.022 15.4 0.2 0.042 14.5 0.0 1.5 2 0 0 2 2 2 0 GW (Gly-Tryp) dipeptide domain DevR PF01905.16 CCF51175.1 - 0.024 13.7 0.1 0.031 13.3 0.1 1.1 1 0 0 1 1 1 0 CRISPR-associated negative auto-regulator DevR/Csa2 WD40 PF00400.32 CCF51176.1 - 9.5e-17 61.1 16.8 0.00061 20.5 0.2 7.7 6 1 1 7 7 7 4 WD domain, G-beta repeat Cytochrom_D1 PF02239.16 CCF51176.1 - 0.056 12.0 0.8 5 5.5 0.0 3.2 4 0 0 4 4 4 0 Cytochrome D1 heme domain DUF4278 PF14105.6 CCF51176.1 - 0.071 13.6 0.5 0.15 12.5 0.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4278) Peptidase_M28 PF04389.17 CCF51177.1 - 1.2e-23 83.8 0.1 1.9e-23 83.2 0.1 1.2 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.28 CCF51177.1 - 7e-08 32.4 0.0 1.2e-07 31.6 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 LTV PF04180.14 CCF51178.1 - 1.6e-97 327.7 28.3 3e-95 320.2 10.4 2.8 3 0 0 3 3 3 2 Low temperature viability protein EXOSC1 PF10447.9 CCF51179.1 - 4.3e-22 78.8 0.2 2.7e-21 76.2 0.2 2.2 1 1 0 1 1 1 1 Exosome component EXOSC1/CSL4 ECR1_N PF14382.6 CCF51179.1 - 0.0002 21.1 0.3 0.00085 19.1 0.3 2.2 1 1 0 1 1 1 1 Exosome complex exonuclease RRP4 N-terminal region Pkinase PF00069.25 CCF51180.1 - 7.9e-46 156.6 0.0 2.2e-45 155.1 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF51180.1 - 5.4e-25 88.1 0.0 8.8e-25 87.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 CCF51180.1 - 0.0069 16.3 0.3 0.015 15.3 0.3 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family RR_TM4-6 PF06459.12 CCF51181.1 - 2.9 7.7 6.3 4.3 7.1 6.3 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Presenilin PF01080.17 CCF51181.1 - 3.7 6.2 4.3 4.3 6.0 4.3 1.2 1 0 0 1 1 1 0 Presenilin GPI-anchored PF10342.9 CCF51182.1 - 9.6e-11 42.3 2.9 9.6e-11 42.3 2.9 2.2 2 1 0 2 2 2 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family Apt1 PF10351.9 CCF51182.1 - 0.9 8.3 8.4 1.5 7.6 8.4 1.3 1 0 0 1 1 1 0 Golgi-body localisation protein domain Pescadillo_N PF06732.11 CCF51183.1 - 1.6e-118 395.2 0.1 1.6e-118 395.2 0.1 1.6 2 0 0 2 2 2 1 Pescadillo N-terminus BRCT_2 PF16589.5 CCF51183.1 - 1.3e-05 25.5 0.0 5.1e-05 23.6 0.0 2.1 1 1 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain DUF3818 PF12825.7 CCF51184.1 - 1.4e-55 188.7 2.9 7.2e-55 186.4 0.0 2.2 2 0 0 2 2 2 1 Domain of unknown function in PX-proteins (DUF3818) PXB PF12828.7 CCF51184.1 - 2.7e-33 114.7 0.0 6e-33 113.6 0.0 1.6 1 0 0 1 1 1 1 PX-associated Acyl-CoA_dh_1 PF00441.24 CCF51185.1 - 1.1e-33 116.6 3.2 1.9e-33 115.8 3.2 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 CCF51185.1 - 2e-19 69.6 0.0 4.1e-19 68.6 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 CCF51185.1 - 1.2e-16 61.4 0.1 3.6e-16 59.8 0.0 1.9 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 CCF51185.1 - 4.3e-15 56.2 4.7 1.7e-14 54.2 2.7 2.3 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain PGM_PMM_III PF02880.16 CCF51185.1 - 0.041 14.1 0.7 0.5 10.6 0.1 2.6 3 0 0 3 3 3 0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III Glyco_hydro_20 PF00728.22 CCF51186.1 - 2.7e-83 280.3 0.0 3.5e-83 279.9 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Glycohydro_20b2 PF14845.6 CCF51186.1 - 1e-17 65.0 0.0 2.3e-17 63.9 0.0 1.6 1 0 0 1 1 1 1 beta-acetyl hexosaminidase like Glyco_hydro_20b PF02838.15 CCF51186.1 - 0.00022 22.0 0.1 0.0029 18.4 0.0 2.4 2 0 0 2 2 2 1 Glycosyl hydrolase family 20, domain 2 Fe_dep_repress PF01325.19 CCF51186.1 - 0.16 12.2 0.0 0.53 10.5 0.0 1.8 1 0 0 1 1 1 0 Iron dependent repressor, N-terminal DNA binding domain MFS_1 PF07690.16 CCF51187.1 - 3.5e-18 65.6 43.7 1.1e-17 64.0 39.9 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily UCH PF00443.29 CCF51188.1 - 4.6e-33 114.8 0.0 6.2e-33 114.4 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 CCF51188.1 - 1.8e-10 41.0 0.2 3.1e-10 40.2 0.2 1.3 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein UCH_1 PF13423.6 CCF51188.1 - 6.9e-05 22.6 0.0 0.01 15.5 0.0 2.5 3 0 0 3 3 3 2 Ubiquitin carboxyl-terminal hydrolase ODC_AZ PF02100.17 CCF51189.1 - 2.5e-13 50.0 0.0 4.6e-13 49.1 0.0 1.3 1 0 0 1 1 1 1 Ornithine decarboxylase antizyme Es2 PF09751.9 CCF51190.1 - 3.4e-107 359.9 2.5 4.1e-107 359.6 2.5 1.1 1 0 0 1 1 1 1 Nuclear protein Es2 ADH_zinc_N PF00107.26 CCF51191.1 - 2.7e-14 53.2 0.1 1.7e-13 50.6 0.0 2.3 2 1 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CCF51191.1 - 1.8e-10 40.7 0.0 3.7e-10 39.7 0.0 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain zf-C2H2 PF00096.26 CCF51192.1 - 0.051 14.1 0.7 0.13 12.8 0.7 1.7 1 0 0 1 1 1 0 Zinc finger, C2H2 type WD40 PF00400.32 CCF51194.1 - 1.3e-38 130.3 18.4 6.8e-07 29.9 0.0 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF51194.1 - 5e-16 58.8 0.0 0.00092 19.5 0.1 5.0 1 1 4 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 CCF51194.1 - 0.0018 17.6 0.0 4 6.7 0.0 3.4 2 1 2 4 4 4 2 WD40-like domain Oberon_cc PF16312.5 CCF51194.1 - 0.43 10.5 1.8 0.75 9.7 1.8 1.3 1 0 0 1 1 1 0 Coiled-coil region of Oberon 4HBT_2 PF13279.6 CCF51195.1 - 2.6e-14 53.8 0.1 3.7e-14 53.3 0.1 1.2 1 0 0 1 1 1 1 Thioesterase-like superfamily 4HBT PF03061.22 CCF51195.1 - 6.2e-06 26.5 0.0 1.2e-05 25.5 0.0 1.6 1 0 0 1 1 1 1 Thioesterase superfamily Acyl-ACP_TE PF01643.17 CCF51195.1 - 0.0029 16.9 0.7 0.013 14.8 0.6 2.0 1 1 0 1 1 1 1 Acyl-ACP thioesterase PPR_2 PF13041.6 CCF51196.1 - 2e-14 53.5 0.1 4.7e-05 23.5 0.0 8.1 9 1 0 9 9 9 2 PPR repeat family PPR PF01535.20 CCF51196.1 - 4.6e-06 26.5 16.9 0.079 13.2 0.0 8.3 11 0 0 11 11 11 2 PPR repeat DUF3368 PF11848.8 CCF51196.1 - 0.081 12.7 0.0 24 4.8 0.0 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF3368) PPR_3 PF13812.6 CCF51196.1 - 0.11 12.6 0.5 57 3.9 0.1 3.8 4 0 0 4 4 4 0 Pentatricopeptide repeat domain PPR_1 PF12854.7 CCF51196.1 - 0.63 9.8 9.2 6.4 6.6 0.5 5.0 6 0 0 6 6 6 0 PPR repeat GATA PF00320.27 CCF51197.1 - 1.5e-13 50.1 5.4 2.8e-13 49.2 5.4 1.5 1 0 0 1 1 1 1 GATA zinc finger PA26 PF04636.13 CCF51197.1 - 2.4 7.0 5.8 5 5.9 5.8 1.5 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Hepar_II_III PF07940.13 CCF51198.1 - 2.2e-09 37.3 0.2 4.3e-09 36.4 0.2 1.4 1 0 0 1 1 1 1 Heparinase II/III-like protein K_oxygenase PF13434.6 CCF51199.1 - 9.5e-11 41.4 0.0 1.6e-06 27.5 0.0 2.4 2 0 0 2 2 2 2 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.14 CCF51199.1 - 1.4e-10 40.9 0.0 2.6e-05 23.6 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CCF51199.1 - 3.7e-10 39.9 0.0 4.7e-09 36.3 0.0 2.3 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FMO-like PF00743.19 CCF51199.1 - 1.3e-09 37.0 1.3 2.8e-08 32.7 1.3 2.4 1 1 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 CCF51199.1 - 1.7e-09 37.4 0.1 9.9e-08 31.6 0.1 3.1 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CCF51199.1 - 2.5e-05 24.3 0.0 0.047 13.7 0.0 3.0 3 0 0 3 3 3 2 FAD-NAD(P)-binding DAO PF01266.24 CCF51199.1 - 6.1e-05 22.8 0.0 0.00013 21.7 0.0 1.6 1 0 0 1 1 1 1 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 CCF51199.1 - 0.0001 21.5 0.0 0.022 13.8 0.0 2.2 2 0 0 2 2 2 2 Lycopene cyclase protein Thi4 PF01946.17 CCF51199.1 - 0.00014 21.2 0.0 0.026 13.8 0.0 2.4 2 0 0 2 2 2 2 Thi4 family GIDA PF01134.22 CCF51199.1 - 0.0075 15.4 0.1 2.1 7.3 0.0 2.1 2 0 0 2 2 2 2 Glucose inhibited division protein A Pyr_redox PF00070.27 CCF51199.1 - 0.0095 16.5 0.0 0.19 12.3 0.0 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Tim17 PF02466.19 CCF51200.1 - 2.5e-32 111.6 5.4 2.6e-32 111.5 4.8 1.3 1 1 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family Phage_holin_3_3 PF16083.5 CCF51200.1 - 0.21 11.7 8.9 0.37 10.9 0.3 2.8 2 1 1 3 3 3 0 LydA holin phage, holin superfamily III Sec5 PF15469.6 CCF51201.1 - 1.6e-55 187.9 0.0 8.9e-55 185.5 0.0 2.3 3 0 0 3 3 3 1 Exocyst complex component Sec5 Vps51 PF08700.11 CCF51201.1 - 0.00062 19.8 0.1 0.007 16.4 0.0 2.8 2 0 0 2 2 2 1 Vps51/Vps67 CK2S PF15011.6 CCF51201.1 - 0.057 13.3 0.2 6.4 6.6 0.0 3.0 3 0 0 3 3 3 0 Casein Kinase 2 substrate Cytochrom_B562 PF07361.11 CCF51201.1 - 0.54 10.9 3.3 12 6.6 0.0 3.2 3 0 0 3 3 3 0 Cytochrome b562 COG2 PF06148.11 CCF51201.1 - 0.86 9.7 0.0 0.86 9.7 0.0 3.5 4 0 0 4 4 4 0 COG (conserved oligomeric Golgi) complex component, COG2 CENP-H PF05837.12 CCF51201.1 - 0.87 10.0 0.0 0.87 10.0 0.0 3.5 3 1 1 4 4 4 0 Centromere protein H (CENP-H) PA28_beta PF02252.18 CCF51202.1 - 4.6e-50 169.1 0.0 6.6e-50 168.6 0.0 1.2 1 0 0 1 1 1 1 Proteasome activator pa28 beta subunit PA28_alpha PF02251.18 CCF51202.1 - 0.004 17.2 0.0 0.008 16.2 0.0 1.5 1 0 0 1 1 1 1 Proteasome activator pa28 alpha subunit DUF4261 PF14080.6 CCF51202.1 - 0.14 12.3 0.1 0.3 11.2 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4261) ABC_membrane PF00664.23 CCF51203.1 - 1.7e-64 218.1 28.3 4.5e-33 115.1 13.9 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 CCF51203.1 - 1.6e-54 184.2 0.0 3.3e-30 105.4 0.0 2.9 2 1 0 2 2 2 2 ABC transporter SMC_N PF02463.19 CCF51203.1 - 6.2e-10 38.9 2.2 0.00031 20.3 0.0 3.8 2 2 1 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CCF51203.1 - 5e-06 26.2 0.8 0.062 13.1 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 CCF51203.1 - 5.1e-06 27.0 1.5 0.009 16.4 0.0 2.9 2 1 0 2 2 2 1 AAA ATPase domain AAA_21 PF13304.6 CCF51203.1 - 5.6e-06 26.4 0.8 0.38 10.5 0.1 3.7 3 1 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system MMR_HSR1 PF01926.23 CCF51203.1 - 5.9e-06 26.3 2.1 0.012 15.7 0.1 2.9 3 0 0 3 3 2 2 50S ribosome-binding GTPase AAA_23 PF13476.6 CCF51203.1 - 0.00037 21.0 4.0 0.58 10.6 0.0 3.1 3 0 0 3 3 2 2 AAA domain RsgA_GTPase PF03193.16 CCF51203.1 - 0.00042 20.3 2.7 0.47 10.4 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase Dynamin_N PF00350.23 CCF51203.1 - 0.0017 18.4 4.0 0.53 10.3 0.2 2.9 2 0 0 2 2 2 2 Dynamin family AAA_15 PF13175.6 CCF51203.1 - 0.011 15.5 0.0 5.2 6.7 0.0 2.5 2 0 0 2 2 2 0 AAA ATPase domain MeaB PF03308.16 CCF51203.1 - 0.013 14.5 0.9 0.38 9.7 0.3 2.3 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Zeta_toxin PF06414.12 CCF51203.1 - 0.018 14.4 0.6 5.9 6.1 0.1 2.4 2 0 0 2 2 2 0 Zeta toxin AAA_30 PF13604.6 CCF51203.1 - 0.019 14.7 2.5 2.8 7.6 0.0 2.9 3 0 0 3 3 3 0 AAA domain ATP_bind_1 PF03029.17 CCF51203.1 - 0.02 14.7 0.7 1.5 8.5 0.1 2.8 3 0 0 3 3 2 0 Conserved hypothetical ATP binding protein AAA_7 PF12775.7 CCF51203.1 - 0.022 14.3 0.3 3.4 7.2 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region FtsK_SpoIIIE PF01580.18 CCF51203.1 - 0.026 13.9 1.4 2 7.7 0.0 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family T2SSE PF00437.20 CCF51203.1 - 0.026 13.6 0.4 6.8 5.7 0.0 3.1 3 0 0 3 3 3 0 Type II/IV secretion system protein Roc PF08477.13 CCF51203.1 - 0.028 14.6 0.2 5.6 7.2 0.1 2.8 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_22 PF13401.6 CCF51203.1 - 0.036 14.3 1.5 13 6.0 0.0 3.0 3 0 0 3 3 3 0 AAA domain cobW PF02492.19 CCF51203.1 - 0.037 13.6 0.9 5 6.7 0.0 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_25 PF13481.6 CCF51203.1 - 0.039 13.5 2.0 1.5 8.4 0.0 3.5 4 0 0 4 4 4 0 AAA domain TrwB_AAD_bind PF10412.9 CCF51203.1 - 0.057 12.3 0.2 5.9 5.7 0.2 2.4 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain NACHT PF05729.12 CCF51203.1 - 0.067 13.1 0.5 4 7.3 0.0 2.5 2 0 0 2 2 2 0 NACHT domain AAA_33 PF13671.6 CCF51203.1 - 0.11 12.6 4.1 18 5.4 0.0 3.4 3 0 0 3 3 3 0 AAA domain DUF815 PF05673.13 CCF51203.1 - 0.13 11.4 0.8 4.6 6.3 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF815) MobB PF03205.14 CCF51203.1 - 0.25 11.3 1.3 24 4.8 0.0 2.8 3 0 0 3 3 2 0 Molybdopterin guanine dinucleotide synthesis protein B IstB_IS21 PF01695.17 CCF51203.1 - 0.28 10.9 1.5 18 5.0 0.0 2.9 3 0 0 3 3 3 0 IstB-like ATP binding protein DUF87 PF01935.17 CCF51203.1 - 0.4 10.7 3.6 0.8 9.7 0.9 2.4 2 0 0 2 2 2 0 Helicase HerA, central domain ABC_ATPase PF09818.9 CCF51203.1 - 1.8 7.3 7.0 4.4 6.0 0.0 3.3 4 0 0 4 4 4 0 Predicted ATPase of the ABC class NPL4 PF05021.15 CCF51204.1 - 2.1e-108 362.4 0.0 2.8e-108 361.9 0.0 1.2 1 0 0 1 1 1 1 NPL4 family zf-NPL4 PF05020.15 CCF51204.1 - 1.2e-64 216.8 2.2 2.2e-64 216.0 2.2 1.4 1 0 0 1 1 1 1 NPL4 family, putative zinc binding region zf-RanBP PF00641.18 CCF51204.1 - 0.00044 19.5 1.0 0.00044 19.5 1.0 1.7 2 0 0 2 2 2 1 Zn-finger in Ran binding protein and others UN_NPL4 PF11543.8 CCF51204.1 - 0.001 19.5 0.0 0.0034 17.8 0.0 1.9 2 0 0 2 2 2 1 Nuclear pore localisation protein NPL4 zf-TRM13_CCCH PF11722.8 CCF51204.1 - 0.026 14.3 0.3 0.061 13.1 0.3 1.6 1 0 0 1 1 1 0 CCCH zinc finger in TRM13 protein Med3 PF11593.8 CCF51204.1 - 0.1 11.7 9.4 0.19 10.9 9.4 1.3 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal DUF3481 PF11980.8 CCF51205.1 - 0.023 14.4 0.1 0.043 13.5 0.1 1.4 1 0 0 1 1 1 0 C-terminal domain of neuropilin glycoprotein DEC-1_N PF04625.13 CCF51205.1 - 0.024 13.7 1.0 0.037 13.1 1.0 1.4 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region RRM_1 PF00076.22 CCF51206.1 - 7.4e-12 44.9 0.1 4.3e-06 26.4 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF3402 PF11882.8 CCF51206.1 - 1.2 8.2 0.0 1.2 8.2 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3402) zf-Tim10_DDP PF02953.15 CCF51207.1 - 1.1e-22 79.4 0.3 1.3e-22 79.2 0.3 1.1 1 0 0 1 1 1 1 Tim10/DDP family zinc finger Complex1_51K PF01512.17 CCF51209.1 - 1.8e-49 167.5 0.0 2.9e-49 166.9 0.0 1.3 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase 51 Kd subunit NADH_4Fe-4S PF10589.9 CCF51209.1 - 1.4e-30 105.2 0.1 3.1e-30 104.1 0.1 1.6 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region SLBB PF10531.9 CCF51209.1 - 6.9e-07 29.0 0.0 1.6e-06 27.9 0.0 1.7 1 0 0 1 1 1 1 SLBB domain Sugar_tr PF00083.24 CCF51211.1 - 5.4e-106 355.2 12.2 6.6e-106 354.9 12.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF51211.1 - 8.8e-23 80.8 20.4 8.8e-23 80.8 20.4 2.6 2 1 1 3 3 3 2 Major Facilitator Superfamily Pkinase PF00069.25 CCF51212.1 - 2.3e-70 237.0 0.0 3.8e-70 236.3 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF51212.1 - 2.4e-48 164.7 0.0 4.1e-48 163.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CCF51212.1 - 0.00088 18.1 0.1 0.0078 15.0 0.0 2.1 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 CCF51212.1 - 0.0022 17.4 0.0 0.0051 16.2 0.0 1.6 1 0 0 1 1 1 1 Kinase-like Peptidase_M57 PF12388.8 CCF51212.1 - 0.025 14.2 1.5 0.049 13.2 1.5 1.4 1 0 0 1 1 1 0 Dual-action HEIGH metallo-peptidase Uso1_p115_head PF04869.14 CCF51212.1 - 0.12 11.5 0.6 0.39 9.8 0.2 2.0 2 1 0 2 2 2 0 Uso1 / p115 like vesicle tethering protein, head region CBF PF03914.17 CCF51212.1 - 0.14 12.2 0.5 9.7 6.2 0.1 2.6 2 0 0 2 2 2 0 CBF/Mak21 family DUF4704 PF15787.5 CCF51212.1 - 0.15 11.2 5.0 1.4 8.1 0.1 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4704) Aldo_ket_red PF00248.21 CCF51213.1 - 1e-27 97.1 0.0 6.1e-15 55.2 0.0 2.1 2 0 0 2 2 2 2 Aldo/keto reductase family RVT_1 PF00078.27 CCF51213.1 - 2.4e-14 53.4 0.0 3.6e-14 52.8 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) PAXNEB PF05625.11 CCF51214.1 - 4.2e-45 154.5 0.0 1.9e-38 132.6 0.0 2.5 2 1 0 2 2 2 2 PAXNEB protein ATPase PF06745.13 CCF51214.1 - 0.15 11.4 0.1 0.89 8.9 0.0 2.0 2 0 0 2 2 2 0 KaiC Ferritin_2 PF13668.6 CCF51215.1 - 5.7e-37 126.9 1.9 1.1e-36 126.0 1.9 1.4 1 0 0 1 1 1 1 Ferritin-like domain MFS_1 PF07690.16 CCF51216.1 - 1.3e-28 100.0 19.7 1.3e-28 100.0 19.7 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily Utp11 PF03998.13 CCF51217.1 - 1e-69 235.2 5.0 1.2e-69 235.0 5.0 1.0 1 0 0 1 1 1 1 Utp11 protein DUF3220 PF11516.8 CCF51217.1 - 0.083 13.1 0.0 0.81 9.9 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3120) SLATT_5 PF18160.1 CCF51217.1 - 0.22 10.8 0.1 0.35 10.2 0.1 1.2 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain family 5 CtaG_Cox11 PF04442.14 CCF51218.1 - 5.2e-57 192.1 0.0 7.6e-57 191.6 0.0 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein CtaG/Cox11 ORC4_C PF14629.6 CCF51220.1 - 8.1e-54 182.3 0.0 1.3e-53 181.6 0.0 1.3 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 4 C-terminus AAA_16 PF13191.6 CCF51220.1 - 2.6e-24 86.5 0.5 1.3e-23 84.2 0.3 2.3 2 1 0 2 2 1 1 AAA ATPase domain AAA PF00004.29 CCF51220.1 - 2.6e-06 27.9 0.2 0.00067 20.1 0.2 2.9 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 CCF51220.1 - 6.8e-05 23.2 0.1 0.0062 16.8 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 CCF51220.1 - 8.3e-05 22.3 0.6 0.00017 21.3 0.1 1.8 2 0 0 2 2 1 1 P-loop containing region of AAA domain DUF815 PF05673.13 CCF51220.1 - 0.0074 15.5 0.1 0.013 14.6 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_7 PF12775.7 CCF51220.1 - 0.0098 15.4 0.0 0.02 14.4 0.0 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_5 PF07728.14 CCF51220.1 - 0.021 14.8 0.1 0.1 12.6 0.0 2.1 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) NACHT PF05729.12 CCF51220.1 - 0.021 14.7 0.0 0.46 10.4 0.0 2.4 2 0 0 2 2 2 0 NACHT domain ABC_tran PF00005.27 CCF51220.1 - 0.1 13.1 0.0 0.27 11.8 0.0 1.8 2 0 0 2 2 1 0 ABC transporter Mg_chelatase PF01078.21 CCF51220.1 - 0.1 11.9 0.1 0.2 11.0 0.1 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_19 PF13245.6 CCF51220.1 - 0.12 12.7 0.1 0.35 11.2 0.1 1.8 1 1 0 1 1 1 0 AAA domain TGF_beta_GS PF08515.12 CCF51220.1 - 0.16 11.5 1.1 15 5.2 0.0 2.6 2 0 0 2 2 2 0 Transforming growth factor beta type I GS-motif DUF4914 PF16260.5 CCF51220.1 - 0.17 9.9 0.1 0.26 9.4 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4914) SNF2_N PF00176.23 CCF51221.1 - 2e-49 168.2 0.0 3.6e-49 167.4 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 CCF51221.1 - 8.5e-21 74.4 0.0 2.2e-20 73.1 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HDA2-3 PF11496.8 CCF51221.1 - 1e-06 28.2 0.0 1e-06 28.2 0.0 1.9 2 0 0 2 2 2 1 Class II histone deacetylase complex subunits 2 and 3 zf-PHD-like PF15446.6 CCF51221.1 - 1.6e-06 27.9 4.9 0.00097 18.8 1.5 2.9 2 0 0 2 2 2 2 PHD/FYVE-zinc-finger like domain Chromo PF00385.24 CCF51221.1 - 1.8e-05 24.6 2.2 0.025 14.5 0.2 2.9 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain ResIII PF04851.15 CCF51221.1 - 2.9e-05 24.1 0.0 7.8e-05 22.7 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit PHD PF00628.29 CCF51221.1 - 6.3e-05 22.8 5.4 0.0028 17.5 1.5 2.9 2 0 0 2 2 2 1 PHD-finger Zf_RING PF16744.5 CCF51221.1 - 7.9e-05 22.7 3.0 7.9e-05 22.7 3.0 2.8 3 0 0 3 3 3 1 KIAA1045 RING finger C1_1 PF00130.22 CCF51221.1 - 0.019 14.9 7.3 0.39 10.6 0.1 3.5 3 1 0 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) PHD_4 PF16866.5 CCF51221.1 - 0.04 14.0 9.1 0.11 12.6 1.5 3.5 3 0 0 3 3 3 0 PHD-finger zf-RING_9 PF13901.6 CCF51221.1 - 3.3 7.6 7.9 3 7.8 3.8 2.6 2 0 0 2 2 2 0 Putative zinc-RING and/or ribbon zf-RING-like PF08746.11 CCF51221.1 - 3.4 8.1 4.6 29 5.1 0.2 2.8 2 0 0 2 2 2 0 RING-like domain Rep_fac_C PF08542.11 CCF51222.1 - 2.2e-25 88.9 0.0 7.2e-25 87.2 0.0 1.9 2 0 0 2 2 2 1 Replication factor C C-terminal domain DNA_pol3_delta2 PF13177.6 CCF51222.1 - 1.3e-12 47.8 0.0 9.6e-11 41.7 0.0 2.2 1 1 0 1 1 1 1 DNA polymerase III, delta subunit AAA PF00004.29 CCF51222.1 - 3e-12 47.1 0.0 5.5e-12 46.2 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 CCF51222.1 - 8.5e-07 29.5 0.0 0.00018 22.0 0.0 2.4 1 1 1 2 2 2 1 AAA ATPase domain AAA_14 PF13173.6 CCF51222.1 - 2e-06 27.9 0.0 3.4e-06 27.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_3 PF07726.11 CCF51222.1 - 1.4e-05 24.9 0.0 2.5e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 CCF51222.1 - 4.2e-05 23.8 0.1 0.011 16.0 0.1 2.3 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.12 CCF51222.1 - 0.001 18.9 0.0 0.0027 17.5 0.0 1.8 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain Rad17 PF03215.15 CCF51222.1 - 0.0021 18.0 0.0 0.0041 17.1 0.0 1.5 1 0 0 1 1 1 1 Rad17 P-loop domain Viral_helicase1 PF01443.18 CCF51222.1 - 0.0023 17.7 0.0 0.0057 16.4 0.0 1.6 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase AAA_24 PF13479.6 CCF51222.1 - 0.011 15.4 0.0 0.022 14.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain DNA_pol3_delta PF06144.13 CCF51222.1 - 0.014 15.2 0.0 0.021 14.6 0.0 1.2 1 0 0 1 1 1 0 DNA polymerase III, delta subunit Mg_chelatase PF01078.21 CCF51222.1 - 0.017 14.5 0.0 0.27 10.6 0.0 2.1 1 1 1 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 CCF51222.1 - 0.024 14.7 0.1 0.094 12.7 0.0 2.0 2 1 0 2 2 1 0 AAA domain (dynein-related subfamily) AAA_11 PF13086.6 CCF51222.1 - 0.036 13.8 0.0 0.058 13.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain MeaB PF03308.16 CCF51222.1 - 0.075 12.0 0.0 0.16 10.9 0.0 1.5 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_assoc_2 PF16193.5 CCF51222.1 - 0.099 13.0 0.0 0.3 11.4 0.0 1.8 2 0 0 2 2 1 0 AAA C-terminal domain PPR_1 PF12854.7 CCF51222.1 - 0.11 12.3 0.4 0.37 10.5 0.4 1.9 1 0 0 1 1 1 0 PPR repeat DUF1302 PF06980.11 CCF51222.1 - 0.22 10.1 0.0 0.3 9.7 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1302) Utp14 PF04615.13 CCF51223.1 - 4.6 5.7 17.0 6.2 5.3 17.0 1.1 1 0 0 1 1 1 0 Utp14 protein PAP2 PF01569.21 CCF51224.1 - 2.2e-11 43.6 9.9 1.4e-10 41.1 9.2 2.2 1 1 0 1 1 1 1 PAP2 superfamily DUF212 PF02681.14 CCF51224.1 - 0.00015 21.9 1.9 0.0019 18.3 0.3 2.4 1 1 1 2 2 2 1 Divergent PAP2 family DUF2614 PF11023.8 CCF51224.1 - 1.2 9.3 3.7 1.1 9.3 0.2 2.2 2 1 0 2 2 2 0 Zinc-ribbon containing domain Kelch_3 PF13415.6 CCF51225.1 - 5.6e-32 109.4 12.1 3.1e-09 36.9 0.0 7.5 7 1 0 7 7 7 5 Galactose oxidase, central domain Kelch_5 PF13854.6 CCF51225.1 - 1.3e-31 108.0 8.4 2.6e-07 30.5 0.2 6.5 6 0 0 6 6 6 5 Kelch motif Kelch_4 PF13418.6 CCF51225.1 - 3.3e-30 103.8 13.5 1.2e-06 28.4 0.2 7.2 6 1 0 6 6 6 5 Galactose oxidase, central domain Kelch_1 PF01344.25 CCF51225.1 - 6.7e-29 99.2 9.3 3.6e-10 39.3 0.4 6.2 6 0 0 6 6 6 4 Kelch motif Kelch_6 PF13964.6 CCF51225.1 - 1.9e-26 91.4 8.6 1.2e-09 38.1 0.4 6.5 5 1 1 6 6 6 5 Kelch motif Kelch_2 PF07646.15 CCF51225.1 - 2.5e-18 65.2 12.1 0.0029 17.5 0.1 6.9 6 1 0 6 6 6 5 Kelch motif zf-C2H2_4 PF13894.6 CCF51227.1 - 0.045 14.6 1.1 0.17 12.8 1.1 2.1 1 0 0 1 1 1 0 C2H2-type zinc finger zf-BED PF02892.15 CCF51227.1 - 0.065 13.3 0.4 0.15 12.1 0.4 1.6 1 0 0 1 1 1 0 BED zinc finger TLD PF07534.16 CCF51229.1 - 1.8e-28 99.5 0.0 1e-25 90.6 0.0 2.5 2 0 0 2 2 2 2 TLD RhoGEF PF00621.20 CCF51230.1 - 1.5e-42 145.9 0.0 2.3e-42 145.3 0.0 1.3 1 0 0 1 1 1 1 RhoGEF domain LRR_8 PF13855.6 CCF51230.1 - 8.3e-09 35.1 6.9 0.0005 19.8 3.5 2.7 1 1 1 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 CCF51230.1 - 7.6e-08 32.5 2.0 0.0021 18.4 0.2 2.9 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 CCF51230.1 - 0.015 15.7 4.0 39 5.3 0.0 4.3 3 0 0 3 3 3 0 Leucine Rich Repeat MMS1_N PF10433.9 CCF51231.1 - 1.7e-153 511.8 0.0 6.3e-153 509.9 0.0 1.8 2 0 0 2 2 2 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.15 CCF51231.1 - 6.1e-94 314.9 0.0 3.3e-93 312.5 0.0 2.1 2 0 0 2 2 2 1 CPSF A subunit region DUF4407 PF14362.6 CCF51232.1 - 0.0025 17.2 1.1 0.0038 16.6 1.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4407) MASE2 PF05230.11 CCF51232.1 - 0.012 15.6 1.3 0.012 15.6 1.3 1.9 2 0 0 2 2 2 0 MASE2 domain Tweety PF04906.13 CCF51232.1 - 0.027 13.1 2.6 0.24 10.0 0.1 2.0 2 0 0 2 2 2 0 Tweety DUF1240 PF06836.12 CCF51232.1 - 0.38 11.3 0.1 0.38 11.3 0.1 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF1240) Tetraspanin PF00335.20 CCF51232.1 - 2.1 8.0 9.6 4.2 7.0 9.5 1.7 1 1 0 1 1 1 0 Tetraspanin family DUF4149 PF13664.6 CCF51232.1 - 6.1 7.2 10.9 2.5 8.5 7.4 2.1 2 1 1 3 3 3 0 Domain of unknown function (DUF4149) SMC_N PF02463.19 CCF51233.1 - 9.3e-26 90.6 0.0 1.8e-25 89.7 0.0 1.5 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 CCF51233.1 - 1e-18 68.6 0.1 1e-18 68.6 0.1 5.9 2 2 1 3 3 1 1 AAA domain AAA_15 PF13175.6 CCF51233.1 - 6e-12 46.0 2.1 6e-12 46.0 2.1 3.4 2 2 1 3 3 3 2 AAA ATPase domain AAA_29 PF13555.6 CCF51233.1 - 4.5e-05 23.1 0.1 9e-05 22.1 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_21 PF13304.6 CCF51233.1 - 0.00026 20.9 10.2 0.027 14.3 0.7 3.8 4 0 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system Spc7 PF08317.11 CCF51233.1 - 0.00028 19.9 20.6 0.00028 19.9 20.6 4.5 2 2 2 4 4 4 2 Spc7 kinetochore protein DUF3450 PF11932.8 CCF51233.1 - 0.00096 18.5 4.1 0.00096 18.5 4.1 6.8 2 2 3 5 5 4 1 Protein of unknown function (DUF3450) ABC_tran PF00005.27 CCF51233.1 - 0.02 15.4 0.3 0.02 15.4 0.3 5.3 4 1 0 4 4 3 0 ABC transporter BBIP10 PF14777.6 CCF51233.1 - 0.045 13.3 0.1 0.39 10.3 0.1 2.7 1 0 0 1 1 1 0 Cilia BBSome complex subunit 10 COG5 PF10392.9 CCF51233.1 - 0.061 13.5 0.2 0.061 13.5 0.2 5.1 6 0 0 6 6 6 0 Golgi transport complex subunit 5 FtsK_SpoIIIE PF01580.18 CCF51233.1 - 0.14 11.5 0.0 0.14 11.5 0.0 3.1 3 1 1 4 4 4 0 FtsK/SpoIIIE family Vac_Fusion PF02346.16 CCF51233.1 - 0.81 9.4 7.2 3.7 7.3 2.9 3.5 2 0 0 2 2 2 0 Chordopoxvirus multifunctional envelope protein A27 ApbA_C PF08546.11 CCF51234.1 - 3.2e-36 124.3 0.0 4.9e-36 123.7 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal ApbA PF02558.16 CCF51234.1 - 1.2e-21 77.0 0.0 2.4e-17 63.0 0.0 2.6 2 0 0 2 2 2 2 Ketopantoate reductase PanE/ApbA DUF3591 PF12157.8 CCF51235.1 - 2.6e-184 613.0 2.5 3.7e-184 612.5 2.5 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3591) zf-CCHC_6 PF15288.6 CCF51235.1 - 0.00021 21.1 3.4 0.00052 19.8 3.4 1.6 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC PF00098.23 CCF51235.1 - 0.28 11.3 1.2 0.54 10.4 1.2 1.4 1 0 0 1 1 1 0 Zinc knuckle UTP25 PF06862.12 CCF51237.1 - 4.3e-183 609.4 1.5 5.2e-183 609.1 1.5 1.1 1 0 0 1 1 1 1 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 MMR_HSR1 PF01926.23 CCF51238.1 - 1.7e-15 57.1 0.1 3.1e-14 53.0 0.0 2.9 3 0 0 3 3 3 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CCF51238.1 - 6.2e-07 29.5 0.0 0.0018 18.2 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase FeoB_N PF02421.18 CCF51238.1 - 1.9e-05 24.2 0.0 0.0001 21.9 0.0 2.0 2 0 0 2 2 2 1 Ferrous iron transport protein B AIG1 PF04548.16 CCF51238.1 - 0.012 14.9 0.0 0.026 13.9 0.0 1.5 1 0 0 1 1 1 0 AIG1 family Dynamin_N PF00350.23 CCF51238.1 - 0.013 15.6 0.6 0.032 14.3 0.0 2.0 2 0 0 2 2 2 0 Dynamin family Sporozoite_P67 PF05642.11 CCF51238.1 - 0.15 10.1 3.9 0.19 9.8 0.1 2.1 2 0 0 2 2 2 0 Sporozoite P67 surface antigen Img2 PF05046.14 CCF51239.1 - 3.7e-24 84.8 0.0 6e-24 84.1 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial large subunit ribosomal protein (Img2) SecE PF00584.20 CCF51240.1 - 1.3e-15 57.0 0.0 1.5e-15 56.8 0.0 1.1 1 0 0 1 1 1 1 SecE/Sec61-gamma subunits of protein translocation complex Ribosomal_L29 PF00831.23 CCF51241.1 - 5.4e-20 71.1 2.0 5.4e-20 71.1 2.0 2.0 2 0 0 2 2 2 1 Ribosomal L29 protein SieB PF14163.6 CCF51241.1 - 0.046 13.2 0.6 0.067 12.7 0.6 1.5 1 1 0 1 1 1 0 Super-infection exclusion protein B CoA_transf_3 PF02515.17 CCF51241.1 - 0.053 12.6 0.3 0.068 12.3 0.3 1.1 1 0 0 1 1 1 0 CoA-transferase family III HiaBD2 PF15403.6 CCF51241.1 - 0.17 12.3 0.0 0.32 11.4 0.0 1.4 1 0 0 1 1 1 0 HiaBD2_N domain of Trimeric autotransporter adhesin (GIN) SF3b10 PF07189.11 CCF51243.1 - 6.2e-33 112.8 0.0 7e-33 112.6 0.0 1.0 1 0 0 1 1 1 1 Splicing factor 3B subunit 10 (SF3b10) TAF6_C PF07571.13 CCF51243.1 - 0.067 13.5 0.1 3.6 8.0 0.0 2.2 1 1 1 2 2 2 0 TAF6 C-terminal HEAT repeat domain Zn_clus PF00172.18 CCF51245.1 - 0.00036 20.6 15.1 0.00053 20.1 15.1 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SNF2_N PF00176.23 CCF51246.1 - 1e-62 211.9 0.7 1.9e-62 211.0 0.7 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain DBINO PF13892.6 CCF51246.1 - 2.5e-50 170.3 16.4 2.5e-50 170.3 16.4 2.9 3 0 0 3 3 3 1 DNA-binding domain Helicase_C PF00271.31 CCF51246.1 - 1.8e-17 63.6 0.0 5.9e-17 62.0 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CCF51246.1 - 1.5e-06 28.3 0.0 4.1e-06 26.9 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 CCF51246.1 - 0.0019 17.4 1.8 0.0026 17.0 0.0 2.1 3 0 0 3 3 3 1 Class II histone deacetylase complex subunits 2 and 3 COG4 PF08318.12 CCF51246.1 - 0.25 10.4 2.5 0.5 9.4 2.5 1.4 1 0 0 1 1 1 0 COG4 transport protein Swi5 PF07061.11 CCF51249.1 - 6.1e-14 51.9 0.2 9.3e-14 51.3 0.2 1.3 1 0 0 1 1 1 1 Swi5 DUF2959 PF11172.8 CCF51249.1 - 0.017 15.3 0.2 0.036 14.2 0.1 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF2959) Pex14_N PF04695.13 CCF51250.1 - 1.5e-23 84.2 0.2 1.5e-23 84.2 0.2 2.8 2 1 1 3 3 3 1 Peroxisomal membrane anchor protein (Pex14p) conserved region Fun_ATP-synt_8 PF05933.13 CCF51250.1 - 0.17 12.1 0.2 0.26 11.5 0.2 1.3 1 0 0 1 1 1 0 Fungal ATP synthase protein 8 (A6L) CENP-B_dimeris PF09026.10 CCF51250.1 - 8 6.9 12.1 13 6.3 7.2 2.6 2 0 0 2 2 2 0 Centromere protein B dimerisation domain RVT_2 PF07727.14 CCF51251.1 - 0.00063 19.5 0.0 0.00089 19.0 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) GDI PF00996.18 CCF51252.1 - 7.7e-209 693.6 0.0 8.7e-209 693.4 0.0 1.0 1 0 0 1 1 1 1 GDP dissociation inhibitor NAD_binding_8 PF13450.6 CCF51252.1 - 0.0056 16.9 0.0 0.013 15.7 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain MMM1 PF10296.9 CCF51253.1 - 2.1e-11 43.5 0.0 3.6e-09 36.1 0.0 2.5 1 1 1 2 2 2 2 Maintenance of mitochondrial morphology protein 1 PH PF00169.29 CCF51253.1 - 0.11 13.0 0.0 0.71 10.4 0.0 2.2 1 1 0 1 1 1 0 PH domain SET PF00856.28 CCF51254.1 - 2.8e-09 37.6 0.0 1.2e-07 32.2 0.0 2.7 2 1 0 2 2 2 1 SET domain dCMP_cyt_deam_1 PF00383.23 CCF51254.1 - 0.096 12.6 0.0 0.19 11.6 0.0 1.5 1 0 0 1 1 1 0 Cytidine and deoxycytidylate deaminase zinc-binding region TFIIA PF03153.13 CCF51255.1 - 9.2e-05 22.6 5.9 0.00012 22.2 5.9 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit HLH PF00010.26 CCF51255.1 - 0.00038 20.4 0.0 0.0025 17.7 0.0 2.1 1 1 0 1 1 1 1 Helix-loop-helix DNA-binding domain AAA_7 PF12775.7 CCF51255.1 - 0.01 15.4 0.0 0.032 13.7 0.0 1.7 2 0 0 2 2 2 0 P-loop containing dynein motor region SnoaL PF07366.12 CCF51255.1 - 0.082 12.7 0.4 0.24 11.2 0.1 2.0 2 0 0 2 2 2 0 SnoaL-like polyketide cyclase DUF5327 PF17261.2 CCF51255.1 - 0.45 11.3 5.6 0.12 13.2 1.3 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5327) GHMP_kinases_N PF00288.26 CCF51256.1 - 5.2e-15 55.4 1.1 1.9e-14 53.6 1.1 2.0 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 CCF51256.1 - 1.2e-06 28.8 0.0 3.7e-06 27.2 0.0 1.9 1 0 0 1 1 1 1 GHMP kinases C terminal Telomerase_RBD PF12009.8 CCF51257.1 - 3.9e-39 133.8 0.9 1.6e-38 131.9 0.4 2.2 2 0 0 2 2 2 1 Telomerase ribonucleoprotein complex - RNA binding domain RVT_1 PF00078.27 CCF51257.1 - 5.1e-11 42.5 0.0 3.5e-07 30.0 0.0 2.4 2 0 0 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) Arg_decarbox_C PF17944.1 CCF51257.1 - 0.0081 16.7 0.2 4.8 7.8 0.0 3.1 3 0 0 3 3 3 2 Arginine decarboxylase C-terminal helical extension Pkinase PF00069.25 CCF51258.1 - 3.2e-45 154.5 0.0 2.4e-27 95.9 0.0 3.8 4 0 0 4 4 4 3 Protein kinase domain Pkinase_Tyr PF07714.17 CCF51258.1 - 5.1e-18 65.3 0.0 5.4e-17 61.9 0.0 2.3 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 CCF51258.1 - 9.3e-05 21.9 0.1 0.00016 21.1 0.1 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 CCF51258.1 - 0.0039 17.1 0.1 0.082 12.8 0.0 3.0 2 1 1 3 3 3 1 Phosphotransferase enzyme family Kdo PF06293.14 CCF51258.1 - 0.0061 15.9 0.1 0.01 15.2 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Endomucin PF07010.12 CCF51258.1 - 8.2 6.3 10.1 0.52 10.2 2.6 2.2 2 0 0 2 2 2 0 Endomucin TNRC6-PABC_bdg PF16608.5 CCF51259.1 - 0.023 14.4 0.2 0.052 13.3 0.1 1.5 1 1 0 1 1 1 0 TNRC6-PABC binding domain Ank_4 PF13637.6 CCF51261.1 - 4.7e-09 36.6 0.0 1.2e-08 35.3 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 CCF51261.1 - 2.7e-08 34.3 0.3 6e-08 33.2 0.3 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 CCF51261.1 - 4.2e-07 30.1 0.5 0.0003 21.0 0.1 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 CCF51261.1 - 1.3e-06 28.3 0.0 0.00048 20.4 0.0 2.8 2 0 0 2 2 2 1 Ankyrin repeat zf-CCCH_2 PF14608.6 CCF51261.1 - 2.6e-06 27.7 8.7 2.6e-06 27.7 8.7 2.5 2 0 0 2 2 2 1 RNA-binding, Nab2-type zinc finger Torus PF16131.5 CCF51261.1 - 1.3e-05 25.8 0.2 1.3e-05 25.8 0.2 4.1 3 0 0 3 3 3 1 Torus domain Ank PF00023.30 CCF51261.1 - 0.00023 21.4 0.4 0.0028 18.0 0.2 2.4 2 0 0 2 2 2 1 Ankyrin repeat zf-CCCH PF00642.24 CCF51261.1 - 0.00097 19.0 12.7 0.0031 17.4 3.6 2.5 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 CCF51261.1 - 0.16 11.8 16.9 0.049 13.4 4.5 2.3 2 0 0 2 2 2 0 CCCH-type zinc finger zf_CCCH_4 PF18345.1 CCF51261.1 - 2.6 8.2 22.9 0.22 11.6 1.5 2.7 3 0 0 3 3 3 0 Zinc finger domain PPR_2 PF13041.6 CCF51262.1 - 3.2e-07 30.4 0.4 0.58 10.4 0.0 5.0 5 0 0 5 5 5 3 PPR repeat family ATP13 PF12921.7 CCF51262.1 - 0.0078 16.1 0.0 0.032 14.1 0.0 2.0 2 0 0 2 2 2 1 Mitochondrial ATPase expression Tup_N PF08581.10 CCF51263.1 - 0.0012 19.1 3.5 0.0012 19.1 3.5 24.1 8 7 15 27 27 27 3 Tup N-terminal TPR_MLP1_2 PF07926.12 CCF51263.1 - 0.0033 17.5 22.8 0.0033 17.5 22.8 21.3 3 2 17 24 24 24 9 TPR/MLP1/MLP2-like protein HIP1_clath_bdg PF16515.5 CCF51263.1 - 0.0082 16.7 13.9 0.0082 16.7 13.9 25.5 2 1 23 26 26 26 5 Clathrin-binding domain of Huntingtin-interacting protein 1 bZIP_2 PF07716.15 CCF51264.1 - 1.2e-08 34.9 15.7 1.2e-08 34.9 15.7 3.4 3 1 0 3 3 3 1 Basic region leucine zipper PRKG1_interact PF15898.5 CCF51264.1 - 0.036 15.0 3.9 0.036 15.0 3.9 2.9 2 1 0 2 2 2 0 cGMP-dependent protein kinase interacting domain Phlebovirus_NSM PF07246.11 CCF51264.1 - 0.054 12.9 0.2 0.054 12.9 0.2 1.5 2 0 0 2 2 2 0 Phlebovirus nonstructural protein NS-M TSC22 PF01166.18 CCF51264.1 - 0.13 12.6 0.1 0.13 12.6 0.1 2.5 2 0 0 2 2 2 0 TSC-22/dip/bun family YabA PF06156.13 CCF51264.1 - 0.25 12.0 0.2 0.25 12.0 0.2 2.8 3 0 0 3 3 3 0 Initiation control protein YabA Adaptin_N PF01602.20 CCF51265.1 - 1e-112 377.4 0.0 1.4e-112 377.0 0.0 1.2 1 0 0 1 1 1 1 Adaptin N terminal region COP-gamma_platf PF08752.10 CCF51265.1 - 1.6e-53 180.9 0.5 3.1e-53 180.0 0.5 1.5 1 0 0 1 1 1 1 Coatomer gamma subunit appendage platform subdomain Coatomer_g_Cpla PF16381.5 CCF51265.1 - 3.6e-34 117.3 0.0 1.5e-33 115.4 0.0 2.2 2 0 0 2 2 2 1 Coatomer subunit gamma-1 C-terminal appendage platform HEAT_2 PF13646.6 CCF51265.1 - 7.4e-17 61.5 0.4 1.7e-09 38.0 0.0 5.6 3 2 3 6 6 6 3 HEAT repeats Cnd1 PF12717.7 CCF51265.1 - 4.6e-06 26.8 5.1 0.33 11.0 0.3 3.8 3 1 0 3 3 3 3 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 CCF51265.1 - 3.8e-05 23.6 3.8 6 7.4 0.2 5.8 5 0 0 5 5 5 2 HEAT repeat HEAT_PBS PF03130.16 CCF51265.1 - 0.2 12.4 2.2 13 6.8 0.0 4.6 5 0 0 5 5 5 0 PBS lyase HEAT-like repeat zf-Nse PF11789.8 CCF51266.1 - 1.3e-14 53.7 0.0 2.9e-14 52.6 0.0 1.6 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit U-box PF04564.15 CCF51266.1 - 1.3e-06 28.5 0.0 2.5e-06 27.6 0.0 1.5 1 0 0 1 1 1 1 U-box domain zf-C3HC4_2 PF13923.6 CCF51266.1 - 4.8e-05 23.1 0.1 0.00037 20.3 0.0 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Transcrip_act PF04949.13 CCF51266.1 - 0.0066 16.4 3.2 0.011 15.6 1.1 2.1 2 0 0 2 2 2 1 Transcriptional activator zf-RING_UBOX PF13445.6 CCF51266.1 - 0.0093 16.0 0.1 0.022 14.8 0.1 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_5 PF17121.5 CCF51266.1 - 0.15 12.0 0.3 0.29 11.1 0.3 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) SIP PF04954.13 CCF51266.1 - 0.21 12.1 1.7 0.22 12.0 0.2 1.8 2 0 0 2 2 2 0 Siderophore-interacting protein zf-C3HC4_4 PF15227.6 CCF51266.1 - 0.56 10.4 2.1 0.56 10.4 0.4 1.9 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING CTP_synth_N PF06418.14 CCF51267.1 - 4.7e-120 399.8 0.0 6.3e-120 399.4 0.0 1.2 1 0 0 1 1 1 1 CTP synthase N-terminus GATase PF00117.28 CCF51267.1 - 7.5e-51 172.6 0.0 1.2e-40 139.3 0.0 2.3 2 0 0 2 2 2 2 Glutamine amidotransferase class-I CbiA PF01656.23 CCF51267.1 - 0.039 14.0 0.0 0.055 13.5 0.0 1.4 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain Peptidase_C26 PF07722.13 CCF51267.1 - 0.17 11.6 0.1 1.2 8.9 0.0 2.2 2 0 0 2 2 2 0 Peptidase C26 Cse1 PF08506.10 CCF51268.1 - 0.15 10.9 0.0 0.22 10.3 0.0 1.2 1 0 0 1 1 1 0 Cse1 Ribosomal_S28e PF01200.18 CCF51269.1 - 8.7e-31 105.7 1.6 9.8e-31 105.6 1.6 1.0 1 0 0 1 1 1 1 Ribosomal protein S28e Haem_degrading PF03928.14 CCF51270.1 - 5.1e-28 97.5 0.0 6.2e-28 97.2 0.0 1.1 1 0 0 1 1 1 1 Haem-degrading YAcAr PF10686.9 CCF51270.1 - 0.028 14.4 0.1 0.087 12.8 0.0 1.8 2 0 0 2 2 2 0 YspA, cpYpsA-related SLOG family Ras PF00071.22 CCF51271.1 - 1.2e-54 184.3 0.0 1.3e-54 184.1 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CCF51271.1 - 1.7e-21 76.6 0.0 2.4e-21 76.2 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CCF51271.1 - 5.9e-06 25.8 0.0 7.9e-06 25.4 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family UQ_con PF00179.26 CCF51272.1 - 2.9e-23 82.1 0.0 5.4e-23 81.2 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Rav1p_C PF12234.8 CCF51273.1 - 8.5e-212 705.0 0.0 1.7e-211 704.0 0.0 1.5 2 0 0 2 2 2 1 RAVE protein 1 C terminal PP-binding PF00550.25 CCF51274.1 - 1.8e-14 53.8 0.4 2.6e-14 53.3 0.4 1.2 1 0 0 1 1 1 1 Phosphopantetheine attachment site PP-binding_2 PF14573.6 CCF51274.1 - 6.8e-08 32.6 0.7 9.4e-08 32.2 0.7 1.2 1 0 0 1 1 1 1 Acyl-carrier hnRNP_Q_AcD PF18360.1 CCF51274.1 - 0.14 12.1 0.1 0.37 10.8 0.0 1.8 2 0 0 2 2 2 0 Heterogeneous nuclear ribonucleoprotein Q acidic domain Ribosomal_L17 PF01196.19 CCF51275.1 - 7e-30 103.8 0.4 1.5e-29 102.7 0.1 1.8 2 0 0 2 2 2 1 Ribosomal protein L17 PPR_2 PF13041.6 CCF51276.1 - 1.9e-07 31.2 0.0 8.5 6.7 0.0 6.1 5 1 1 6 6 6 3 PPR repeat family PPR_3 PF13812.6 CCF51276.1 - 0.00025 21.1 0.1 2.4 8.3 0.0 4.7 4 1 2 6 6 6 1 Pentatricopeptide repeat domain PPR PF01535.20 CCF51276.1 - 0.00058 19.9 0.3 24 5.4 0.0 5.2 6 0 0 6 6 6 0 PPR repeat B12-binding_2 PF02607.17 CCF51276.1 - 0.0016 18.8 1.0 4.9 7.7 0.0 3.9 3 1 1 4 4 4 1 B12 binding domain PPR_1 PF12854.7 CCF51276.1 - 0.0025 17.5 0.0 5.6 6.7 0.0 3.6 3 0 0 3 3 3 1 PPR repeat PPR_long PF17177.4 CCF51276.1 - 0.0026 17.2 1.0 0.1 11.9 0.1 3.2 4 0 0 4 4 4 1 Pentacotripeptide-repeat region of PRORP TPR_16 PF13432.6 CCF51276.1 - 0.022 15.4 8.2 9.8 6.9 0.1 4.8 4 0 0 4 4 4 0 Tetratricopeptide repeat SPO22 PF08631.10 CCF51276.1 - 0.058 12.9 0.1 0.21 11.0 0.1 2.0 1 0 0 1 1 1 0 Meiosis protein SPO22/ZIP4 like TPR_19 PF14559.6 CCF51276.1 - 0.25 11.9 1.9 4.7 7.8 0.3 3.6 2 1 0 2 2 2 0 Tetratricopeptide repeat Opi1 PF08618.10 CCF51277.1 - 0.021 14.1 1.0 0.037 13.3 1.0 1.5 1 1 0 1 1 1 0 Transcription factor Opi1 PH PF00169.29 CCF51278.1 - 2.4e-06 28.0 0.0 0.048 14.2 0.0 2.7 2 0 0 2 2 2 2 PH domain Heme_oxygenase PF01126.20 CCF51279.1 - 6.1e-20 71.9 0.1 2.2e-15 57.0 0.0 2.7 2 1 0 2 2 2 2 Heme oxygenase Bin3 PF06859.12 CCF51280.1 - 7.5e-16 58.7 0.0 1.4e-15 57.8 0.0 1.5 1 0 0 1 1 1 1 Bicoid-interacting protein 3 (Bin3) Methyltransf_31 PF13847.6 CCF51280.1 - 6.1e-08 32.6 0.1 1.1e-07 31.8 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain CheR PF01739.18 CCF51280.1 - 4.1e-06 26.4 0.0 1.1e-05 25.0 0.0 1.7 2 0 0 2 2 2 1 CheR methyltransferase, SAM binding domain Methyltransf_25 PF13649.6 CCF51280.1 - 4.7e-05 24.0 0.0 0.0005 20.7 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCF51280.1 - 6e-05 22.9 0.0 0.00017 21.5 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF51280.1 - 0.00044 20.9 0.0 0.0012 19.5 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF51280.1 - 0.017 15.8 0.0 0.063 13.9 0.0 2.0 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_32 PF13679.6 CCF51280.1 - 0.019 15.0 0.0 0.084 12.9 0.0 1.9 2 0 0 2 2 2 0 Methyltransferase domain NCBP3 PF10309.9 CCF51281.1 - 1.1e-06 28.4 0.0 2.5e-06 27.2 0.0 1.6 2 0 0 2 2 2 1 Nuclear cap-binding protein subunit 3 RNA_bind PF08675.11 CCF51281.1 - 0.00048 20.1 0.0 0.00097 19.1 0.0 1.4 1 0 0 1 1 1 1 RNA binding domain RRM_3 PF08777.11 CCF51281.1 - 0.19 11.8 0.0 0.29 11.2 0.0 1.2 1 0 0 1 1 1 0 RNA binding motif Rsm22 PF09243.10 CCF51282.1 - 2.4e-36 125.4 0.7 3.3e-17 62.7 0.0 4.9 4 1 0 4 4 4 3 Mitochondrial small ribosomal subunit Rsm22 Ima1_N PF09779.9 CCF51283.1 - 1.5e-19 71.2 1.0 1.5e-19 71.2 1.0 2.3 3 0 0 3 3 3 1 Ima1 N-terminal domain Lyase_1 PF00206.20 CCF51284.1 - 1.2e-119 399.3 0.0 1.8e-119 398.8 0.0 1.2 1 0 0 1 1 1 1 Lyase FumaraseC_C PF10415.9 CCF51284.1 - 6.7e-20 71.3 0.4 2.5e-18 66.2 0.1 2.6 2 0 0 2 2 2 1 Fumarase C C-terminus ADH_N PF08240.12 CCF51284.1 - 0.054 13.4 0.0 0.12 12.2 0.0 1.5 1 0 0 1 1 1 0 Alcohol dehydrogenase GroES-like domain MMR_HSR1 PF01926.23 CCF51285.1 - 1.7e-10 41.0 0.1 5.9e-10 39.2 0.1 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.6 CCF51285.1 - 0.062 13.7 0.1 0.14 12.6 0.1 1.6 1 0 0 1 1 1 0 AAA ATPase domain FeoB_N PF02421.18 CCF51285.1 - 0.081 12.5 0.0 0.17 11.4 0.0 1.5 1 0 0 1 1 1 0 Ferrous iron transport protein B AAA_29 PF13555.6 CCF51285.1 - 0.15 11.8 0.0 0.31 10.8 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Dynamin_N PF00350.23 CCF51285.1 - 0.17 11.9 1.3 2 8.4 0.2 2.7 2 1 0 2 2 2 0 Dynamin family Carn_acyltransf PF00755.20 CCF51286.1 - 3e-201 670.1 0.1 3.5e-201 669.9 0.1 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase AMP-binding PF00501.28 CCF51288.1 - 4e-46 157.5 0.0 5.9e-46 156.9 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme PP-binding PF00550.25 CCF51288.1 - 3.6e-13 49.7 0.6 7.2e-13 48.7 0.6 1.5 1 0 0 1 1 1 1 Phosphopantetheine attachment site Hexapep PF00132.24 CCF51288.1 - 1.1e-10 40.8 5.0 0.0045 16.7 0.1 7.0 8 0 0 8 8 8 3 Bacterial transferase hexapeptide (six repeats) AMP-binding_C PF13193.6 CCF51288.1 - 0.00034 21.5 3.3 0.022 15.7 0.0 3.0 3 0 0 3 3 3 1 AMP-binding enzyme C-terminal domain GH3 PF03321.13 CCF51288.1 - 0.1 11.4 0.0 1.5 7.6 0.0 2.0 2 0 0 2 2 2 0 GH3 auxin-responsive promoter Hexapep_2 PF14602.6 CCF51288.1 - 0.1 12.3 8.1 4 7.3 0.0 4.8 4 1 1 5 5 5 0 Hexapeptide repeat of succinyl-transferase ERAP1_C PF11838.8 CCF51289.1 - 4.3e-79 266.3 0.4 7e-79 265.6 0.4 1.4 1 0 0 1 1 1 1 ERAP1-like C-terminal domain Peptidase_M1 PF01433.20 CCF51289.1 - 1.3e-67 227.6 0.0 1.9e-67 227.1 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M1 domain Peptidase_M1_N PF17900.1 CCF51289.1 - 7.4e-41 140.4 2.9 1.9e-37 129.3 0.2 2.3 2 0 0 2 2 2 2 Peptidase M1 N-terminal domain SKN1 PF03935.15 CCF51294.1 - 7.9e-189 628.2 2.8 9.7e-189 627.9 2.8 1.0 1 0 0 1 1 1 1 Beta-glucan synthesis-associated protein (SKN1) Neurensin PF14927.6 CCF51294.1 - 0.14 11.9 0.0 0.3 10.8 0.0 1.5 1 0 0 1 1 1 0 Neurensin PfkB PF00294.24 CCF51295.1 - 1.6e-66 224.7 3.1 1.8e-66 224.5 3.1 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Phos_pyr_kin PF08543.12 CCF51295.1 - 0.00015 21.2 0.0 0.00032 20.1 0.0 1.5 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase SNF2_N PF00176.23 CCF51296.1 - 7.9e-66 222.2 0.0 1.2e-65 221.6 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain HIRAN PF08797.11 CCF51296.1 - 1.8e-28 98.3 0.0 3.3e-28 97.4 0.0 1.5 1 0 0 1 1 1 1 HIRAN domain Helicase_C PF00271.31 CCF51296.1 - 8.5e-13 48.6 0.0 2.1e-12 47.4 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-RING_5 PF14634.6 CCF51296.1 - 8.5e-05 22.4 13.1 0.00014 21.7 13.1 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 CCF51296.1 - 0.00011 22.5 13.2 0.00019 21.7 13.2 1.4 1 0 0 1 1 1 1 Ring finger domain ResIII PF04851.15 CCF51296.1 - 0.0003 20.8 0.0 0.21 11.6 0.0 2.7 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit zf-RING_UBOX PF13445.6 CCF51296.1 - 0.0067 16.4 10.9 0.013 15.5 10.9 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 CCF51296.1 - 0.0096 15.8 14.1 0.017 15.0 14.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 CCF51296.1 - 0.088 12.7 14.2 0.16 11.9 14.2 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 CCF51296.1 - 1 9.4 5.4 2.1 8.4 5.4 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger FANCL_C PF11793.8 CCF51296.1 - 2.6 8.3 7.4 5.4 7.3 7.4 1.5 1 0 0 1 1 1 0 FANCL C-terminal domain Cupin_8 PF13621.6 CCF51297.1 - 8.6e-13 48.6 0.0 3.2e-12 46.7 0.0 1.8 1 1 0 1 1 1 1 Cupin-like domain JmjC PF02373.22 CCF51297.1 - 7.7e-08 32.8 0.0 9.9e-07 29.2 0.0 2.4 1 1 0 1 1 1 1 JmjC domain, hydroxylase Cupin_4 PF08007.12 CCF51297.1 - 3e-05 23.6 0.1 0.00015 21.4 0.0 2.0 2 0 0 2 2 2 1 Cupin superfamily protein Cupin_1 PF00190.22 CCF51297.1 - 0.13 11.9 0.0 0.25 11.0 0.0 1.4 1 0 0 1 1 1 0 Cupin F-box-like PF12937.7 CCF51297.1 - 0.17 11.8 0.0 0.17 11.8 0.0 1.9 2 0 0 2 2 2 0 F-box-like INO80_Ies4 PF08193.11 CCF51297.1 - 3.2 7.7 15.6 0.63 10.0 9.4 2.4 2 0 0 2 2 2 0 INO80 complex subunit Ies4 Raptor_N PF14538.6 CCF51298.1 - 1.5e-60 203.4 0.0 2.6e-60 202.6 0.0 1.4 1 0 0 1 1 1 1 Raptor N-terminal CASPase like domain WD40 PF00400.32 CCF51298.1 - 5.6e-06 27.0 7.3 3.6 8.6 0.1 5.9 5 0 0 5 5 5 2 WD domain, G-beta repeat BBS2_Mid PF14783.6 CCF51298.1 - 4.3e-05 23.5 0.0 0.0095 16.0 0.0 2.7 2 0 0 2 2 2 1 Ciliary BBSome complex subunit 2, middle region HEAT PF02985.22 CCF51298.1 - 0.00013 21.9 6.8 0.045 14.0 0.0 4.8 5 0 0 5 5 5 2 HEAT repeat HEAT_2 PF13646.6 CCF51298.1 - 0.12 12.8 1.0 1.1 9.7 0.1 3.1 3 1 0 3 3 3 0 HEAT repeats Cnd1 PF12717.7 CCF51298.1 - 0.2 11.7 0.0 0.71 9.9 0.0 1.9 2 0 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1 CAF1C_H4-bd PF12265.8 CCF51299.1 - 4e-16 59.0 0.1 1.2e-15 57.5 0.0 1.9 2 0 0 2 2 2 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 CCF51299.1 - 2e-15 56.9 9.8 5.3e-06 27.1 0.1 4.5 4 0 0 4 4 4 3 WD domain, G-beta repeat eIF2A PF08662.11 CCF51299.1 - 0.00038 20.4 0.0 0.0071 16.3 0.0 2.1 1 1 1 2 2 2 1 Eukaryotic translation initiation factor eIF2A Lactonase PF10282.9 CCF51299.1 - 0.088 12.0 0.0 0.28 10.4 0.0 1.7 1 1 0 1 1 1 0 Lactonase, 7-bladed beta-propeller Zip PF02535.22 CCF51300.1 - 4.5e-24 85.3 39.5 5.4e-20 71.9 28.0 3.4 2 1 0 2 2 2 2 ZIP Zinc transporter CHD5 PF04420.14 CCF51301.1 - 1.8e-53 180.7 0.5 2.9e-53 180.0 0.5 1.3 1 0 0 1 1 1 1 CHD5-like protein DivIC PF04977.15 CCF51301.1 - 0.14 11.9 2.2 0.3 10.9 0.0 2.6 2 1 1 3 3 3 0 Septum formation initiator RCC1_2 PF13540.6 CCF51302.1 - 1.6e-05 24.5 4.0 0.0049 16.6 0.3 4.0 5 0 0 5 5 5 2 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 CCF51302.1 - 3.5e-05 24.3 2.9 3.7 8.2 0.0 4.3 4 0 0 4 4 4 3 Regulator of chromosome condensation (RCC1) repeat HTH_17 PF12728.7 CCF51302.1 - 0.26 11.5 0.4 0.74 10.0 0.0 2.0 3 0 0 3 3 3 0 Helix-turn-helix domain SOG2 PF10428.9 CCF51303.1 - 3.6 6.7 9.6 3.7 6.6 9.6 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein RRM_1 PF00076.22 CCF51304.1 - 5.3e-16 58.2 0.0 1.3e-06 28.1 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 CCF51304.1 - 1.2e-07 31.4 0.0 4.7e-05 23.0 0.1 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 CCF51304.1 - 0.0021 17.9 0.0 0.03 14.2 0.0 2.2 2 0 0 2 2 2 1 Occluded RNA-recognition motif DUF1027 PF06265.11 CCF51304.1 - 0.069 13.2 0.0 0.14 12.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1027) Mitoc_mL59 PF18126.1 CCF51304.1 - 2.6 8.3 7.8 2.3 8.5 6.2 1.7 1 1 0 1 1 1 0 Mitochondrial ribosomal protein mL59 Myb_DNA-bind_7 PF15963.5 CCF51305.1 - 1.5e-24 85.6 0.0 3.6e-24 84.5 0.0 1.6 1 0 0 1 1 1 1 Myb DNA-binding like HMG_box PF00505.19 CCF51305.1 - 7e-16 58.4 0.1 1.7e-15 57.2 0.1 1.7 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 CCF51305.1 - 1.8e-09 38.0 0.1 5.1e-09 36.6 0.1 1.9 1 0 0 1 1 1 1 HMG-box domain Myb_DNA-binding PF00249.31 CCF51305.1 - 7.7e-05 22.8 0.0 0.00014 22.0 0.0 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain Haspin_kinase PF12330.8 CCF51306.1 - 9.8e-65 218.9 0.3 1.9e-64 217.9 0.0 1.5 2 0 0 2 2 2 1 Haspin like kinase domain Pkinase_Tyr PF07714.17 CCF51306.1 - 0.1 11.8 0.0 0.19 11.0 0.0 1.5 1 0 0 1 1 1 0 Protein tyrosine kinase Ribosomal_L1 PF00687.21 CCF51307.1 - 5.1e-20 72.1 0.1 2.7e-19 69.7 0.1 1.9 1 1 0 1 1 1 1 Ribosomal protein L1p/L10e family GARS_A PF01071.19 CCF51308.1 - 1.1e-71 240.7 0.0 1.6e-71 240.1 0.0 1.3 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain GARS_N PF02844.15 CCF51308.1 - 7.4e-29 100.4 0.0 2.8e-28 98.5 0.0 2.1 2 0 0 2 2 2 1 Phosphoribosylglycinamide synthetase, N domain GARS_C PF02843.16 CCF51308.1 - 1.2e-27 96.0 0.5 2.4e-27 95.0 0.5 1.5 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, C domain AIRS_C PF02769.22 CCF51308.1 - 1.6e-27 96.6 0.0 2.9e-27 95.7 0.0 1.4 1 0 0 1 1 1 1 AIR synthase related protein, C-terminal domain AIRS PF00586.24 CCF51308.1 - 1.1e-13 51.7 0.7 8.9e-13 48.7 0.9 2.3 2 0 0 2 2 2 1 AIR synthase related protein, N-terminal domain Pyr_redox_2 PF07992.14 CCF51309.1 - 2.8e-27 95.7 0.0 8.2e-15 54.8 0.0 4.1 4 0 0 4 4 4 4 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CCF51309.1 - 1.1e-15 57.9 0.1 2.8e-11 43.8 0.0 2.9 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 CCF51309.1 - 0.0031 16.8 0.0 1.2 8.3 0.0 2.3 2 0 0 2 2 2 2 Thi4 family Trp_halogenase PF04820.14 CCF51309.1 - 0.028 13.3 0.1 2.8 6.7 0.0 2.8 3 0 0 3 3 3 0 Tryptophan halogenase DAO PF01266.24 CCF51309.1 - 0.075 12.6 1.8 16 5.0 0.0 3.1 2 1 1 3 3 3 0 FAD dependent oxidoreductase Pribosyltran PF00156.27 CCF51309.1 - 0.1 12.1 0.0 17 4.9 0.0 2.4 2 0 0 2 2 2 0 Phosphoribosyl transferase domain K_oxygenase PF13434.6 CCF51309.1 - 0.13 11.4 0.1 0.71 8.9 0.0 2.0 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) MFS_1 PF07690.16 CCF51311.1 - 2.1e-26 92.7 31.2 4.9e-26 91.5 28.6 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily MFS_4 PF06779.14 CCF51311.1 - 0.00076 18.9 5.0 0.00076 18.9 5.0 2.5 2 1 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB NMT1 PF09084.11 CCF51312.1 - 8.9e-76 254.6 0.0 1.2e-75 254.2 0.0 1.2 1 0 0 1 1 1 1 NMT1/THI5 like NMT1_2 PF13379.6 CCF51312.1 - 0.02 14.6 0.1 2.3 7.8 0.0 2.9 3 0 0 3 3 3 0 NMT1-like family PCI PF01399.27 CCF51313.1 - 1.7e-20 73.5 0.9 4.5e-20 72.1 0.9 1.8 1 0 0 1 1 1 1 PCI domain TPR_10 PF13374.6 CCF51313.1 - 0.0056 16.5 0.6 0.99 9.4 0.1 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat FmiP_Thoc5 PF09766.9 CCF51313.1 - 0.0073 15.6 0.1 0.015 14.6 0.1 1.5 1 0 0 1 1 1 1 Fms-interacting protein/Thoc5 TPR_12 PF13424.6 CCF51313.1 - 0.041 14.2 0.1 0.38 11.1 0.1 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.6 CCF51313.1 - 0.057 13.5 1.9 0.96 9.6 0.1 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat Vps39_1 PF10366.9 CCF51313.1 - 0.093 13.0 1.7 0.24 11.7 0.2 2.3 3 0 0 3 3 3 0 Vacuolar sorting protein 39 domain 1 TPR_2 PF07719.17 CCF51313.1 - 0.19 11.9 0.2 0.19 11.9 0.2 3.1 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_14 PF13428.6 CCF51313.1 - 0.29 12.1 4.4 5.1 8.2 0.0 3.9 3 1 1 4 4 4 0 Tetratricopeptide repeat Acyltransferase PF01553.21 CCF51314.1 - 3.4e-21 75.3 0.0 7.6e-21 74.1 0.0 1.6 1 0 0 1 1 1 1 Acyltransferase MarR PF01047.22 CCF51314.1 - 0.047 13.6 0.0 0.27 11.2 0.0 2.2 2 0 0 2 2 2 0 MarR family RVT_1 PF00078.27 CCF51315.1 - 1.9e-08 34.1 0.0 3.1e-08 33.4 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Phage_integrase PF00589.22 CCF51315.1 - 0.00024 21.0 0.0 0.00053 19.8 0.0 1.5 1 0 0 1 1 1 1 Phage integrase family RT_RNaseH_2 PF17919.1 CCF51315.1 - 0.00065 19.7 0.0 0.0014 18.6 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 CCF51315.1 - 0.00069 19.9 0.0 0.0015 18.8 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Peptidase_M18 PF02127.15 CCF51316.1 - 6.4e-169 562.3 0.0 7.4e-169 562.1 0.0 1.0 1 0 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) Peptidase_M42 PF05343.14 CCF51316.1 - 8.2e-05 21.8 0.0 0.055 12.5 0.0 2.2 2 0 0 2 2 2 2 M42 glutamyl aminopeptidase Acyl-CoA_dh_M PF02770.19 CCF51316.1 - 0.01 16.0 0.0 0.28 11.4 0.0 2.5 2 0 0 2 2 2 0 Acyl-CoA dehydrogenase, middle domain IBN_N PF03810.19 CCF51317.1 - 3.2e-07 30.2 0.0 6.4e-06 26.0 0.0 3.2 4 0 0 4 4 4 1 Importin-beta N-terminal domain CAS_CSE1 PF03378.15 CCF51317.1 - 0.00019 20.1 0.1 0.021 13.3 0.0 2.5 2 0 0 2 2 2 2 CAS/CSE protein, C-terminus Urb2 PF10441.9 CCF51317.1 - 0.015 15.3 0.1 0.14 12.1 0.0 2.7 3 0 0 3 3 3 0 Urb2/Npa2 family Cse1 PF08506.10 CCF51317.1 - 0.02 13.8 0.0 0.059 12.2 0.0 1.8 1 0 0 1 1 1 0 Cse1 Xpo1 PF08389.12 CCF51317.1 - 0.04 14.0 0.1 0.36 10.9 0.0 2.8 3 1 0 3 3 3 0 Exportin 1-like protein RIX1 PF08167.12 CCF51317.1 - 0.34 10.6 3.0 0.52 10.0 0.1 2.8 3 0 0 3 3 3 0 rRNA processing/ribosome biogenesis HEAT PF02985.22 CCF51317.1 - 0.38 11.1 6.2 2.4 8.6 0.0 5.0 6 0 0 6 6 6 0 HEAT repeat Fungal_trans_2 PF11951.8 CCF51318.1 - 1.6e-09 37.1 1.5 1.3e-08 34.1 0.0 2.4 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF51318.1 - 5.3e-08 32.9 8.3 1.3e-07 31.6 8.3 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain EcoEI_R_C PF08463.10 CCF51318.1 - 0.16 12.1 0.0 0.36 10.9 0.0 1.5 1 0 0 1 1 1 0 EcoEI R protein C-terminal peroxidase PF00141.23 CCF51321.1 - 1.4e-82 276.8 0.0 1.6e-43 149.0 0.0 2.3 2 1 0 2 2 2 2 Peroxidase AA_permease_2 PF13520.6 CCF51322.1 - 4.1e-46 157.7 48.9 5.5e-46 157.3 48.9 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 CCF51322.1 - 1.6e-18 66.6 46.1 5.4e-18 64.8 37.8 2.0 2 0 0 2 2 2 2 Amino acid permease Cu_amine_oxid PF01179.20 CCF51323.1 - 3.6e-154 513.6 0.0 4.3e-154 513.4 0.0 1.1 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain Cu_amine_oxidN2 PF02727.16 CCF51323.1 - 1.8e-06 28.1 0.1 4.9e-06 26.7 0.1 1.8 1 0 0 1 1 1 1 Copper amine oxidase, N2 domain FF PF01846.19 CCF51324.1 - 1.9e-23 82.3 14.6 1.9e-05 24.7 0.1 6.6 6 1 0 6 6 6 4 FF domain WW PF00397.26 CCF51324.1 - 1.1e-06 28.6 8.3 9.1e-05 22.5 3.4 2.7 2 0 0 2 2 2 2 WW domain RhoGAP-FF1 PF16512.5 CCF51324.1 - 0.018 15.7 11.0 0.025 15.3 0.1 3.8 3 2 0 3 3 3 0 p190-A and -B Rho GAPs FF domain Adhesin_P1 PF03257.13 CCF51324.1 - 0.74 10.4 2.7 1.9 9.0 2.1 2.0 1 1 0 1 1 1 0 Mycoplasma adhesin P1 DUF3752 PF12572.8 CCF51325.1 - 6e-15 56.1 56.4 1.7e-13 51.4 11.4 3.6 2 1 2 4 4 4 2 Protein of unknown function (DUF3752) SMC_N PF02463.19 CCF51326.1 - 1.5e-17 63.8 0.0 3.5e-17 62.6 0.0 1.6 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 CCF51326.1 - 1e-11 45.8 26.0 1e-11 45.8 26.0 5.9 2 2 1 3 3 3 1 AAA domain AAA_15 PF13175.6 CCF51326.1 - 2.6e-06 27.4 0.2 2.6e-06 27.4 0.2 3.1 2 2 0 2 2 2 1 AAA ATPase domain AAA_21 PF13304.6 CCF51326.1 - 0.00018 21.5 6.4 0.11 12.2 0.1 3.5 4 0 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 CCF51326.1 - 0.0088 15.8 0.0 0.018 14.8 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain IstB_IS21 PF01695.17 CCF51326.1 - 0.023 14.5 0.0 0.085 12.6 0.0 2.0 1 0 0 1 1 1 0 IstB-like ATP binding protein FAM194 PF14977.6 CCF51326.1 - 0.041 13.2 1.2 0.094 12.0 0.2 2.1 2 0 0 2 2 2 0 FAM194 protein AAA PF00004.29 CCF51326.1 - 0.66 10.4 3.1 0.75 10.2 0.0 2.8 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) Seadorna_VP6 PF07407.11 CCF51326.1 - 2.5 7.0 7.5 4.7 6.0 7.5 1.4 1 0 0 1 1 1 0 Seadornavirus VP6 protein Abhydrolase_1 PF00561.20 CCF51327.1 - 3.7e-35 121.8 0.0 1.7e-31 109.8 0.0 2.6 2 1 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CCF51327.1 - 3.3 8.2 14.6 0.48 11.0 2.3 2.5 1 1 0 2 2 2 0 Alpha/beta hydrolase family ISK_Channel PF02060.15 CCF51328.1 - 1.8 8.3 3.3 0.71 9.6 0.3 1.9 2 0 0 2 2 2 0 Slow voltage-gated potassium channel 7tm_1 PF00001.21 CCF51329.1 - 2.6e-13 49.9 4.6 2.6e-13 49.9 4.6 1.3 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Git3 PF11710.8 CCF51329.1 - 1.4e-10 41.3 14.1 1.4e-10 41.3 14.1 1.6 2 0 0 2 2 2 1 G protein-coupled glucose receptor regulating Gpa2 GPR_Gpa2_C PF11970.8 CCF51329.1 - 0.00075 19.5 0.0 0.0028 17.7 0.0 2.0 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 C-term DUF3382 PF11862.8 CCF51329.1 - 1.6 9.1 4.7 0.88 9.9 0.1 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3382) DnaJ PF00226.31 CCF51330.1 - 3e-13 49.7 0.0 5.5e-13 48.8 0.0 1.5 1 0 0 1 1 1 1 DnaJ domain NOC3p PF07540.11 CCF51331.1 - 5.8e-30 103.6 1.4 1.1e-29 102.7 0.0 2.3 2 0 0 2 2 2 1 Nucleolar complex-associated protein CBF PF03914.17 CCF51331.1 - 1.6e-08 34.8 0.9 1.6e-08 34.8 0.9 2.8 2 1 0 2 2 2 1 CBF/Mak21 family 60KD_IMP PF02096.20 CCF51331.1 - 0.054 13.4 2.5 0.1 12.5 2.5 1.4 1 0 0 1 1 1 0 60Kd inner membrane protein SNase PF00565.17 CCF51331.1 - 0.29 11.6 4.7 1.1 9.8 4.7 2.0 1 0 0 1 1 1 0 Staphylococcal nuclease homologue LEA_2 PF03168.13 CCF51332.1 - 0.041 14.4 0.1 0.12 12.9 0.0 1.9 2 0 0 2 2 2 0 Late embryogenesis abundant protein DHHC PF01529.20 CCF51332.1 - 0.15 12.2 1.3 0.45 10.6 1.3 1.6 1 1 0 1 1 1 0 DHHC palmitoyltransferase zf-CCHC PF00098.23 CCF51333.1 - 0.00085 19.3 6.3 0.0045 17.0 6.3 2.4 1 0 0 1 1 1 1 Zinc knuckle FAM216B PF15107.6 CCF51334.1 - 0.031 14.1 0.1 0.053 13.4 0.1 1.3 1 0 0 1 1 1 0 FAM216B protein family rve PF00665.26 CCF51337.1 - 3.8e-11 43.2 0.0 7.5e-11 42.3 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain gag_pre-integrs PF13976.6 CCF51337.1 - 2e-06 27.5 0.6 5.7e-06 26.1 0.6 1.8 1 0 0 1 1 1 1 GAG-pre-integrase domain Amidase PF01425.21 CCF51338.1 - 3.8e-78 263.4 0.0 6.3e-67 226.5 0.0 2.1 2 0 0 2 2 2 2 Amidase XFP_N PF09364.10 CCF51339.1 - 2.1e-129 431.5 0.0 3e-129 431.0 0.0 1.2 1 0 0 1 1 1 1 XFP N-terminal domain XFP_C PF09363.10 CCF51339.1 - 1.2e-68 230.6 0.0 2.2e-68 229.7 0.0 1.5 1 0 0 1 1 1 1 XFP C-terminal domain XFP PF03894.15 CCF51339.1 - 9.5e-64 214.3 0.0 1.8e-63 213.5 0.0 1.5 1 0 0 1 1 1 1 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase TPP_enzyme_C PF02775.21 CCF51339.1 - 0.0068 16.2 0.1 0.018 14.8 0.1 1.7 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain UAF_Rrn10 PF05234.11 CCF51339.1 - 0.0091 16.2 0.0 0.024 14.9 0.0 1.6 1 0 0 1 1 1 1 UAF complex subunit Rrn10 Transket_pyr PF02779.24 CCF51339.1 - 0.028 14.1 0.0 0.078 12.7 0.0 1.8 1 0 0 1 1 1 0 Transketolase, pyrimidine binding domain DUF1847 PF08901.11 CCF51339.1 - 0.18 11.4 0.0 0.35 10.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1847) Acetate_kinase PF00871.17 CCF51340.1 - 1.2e-66 225.0 0.0 1.2e-64 218.4 0.0 2.8 1 1 0 1 1 1 1 Acetokinase family Glyco_hydro_10 PF00331.20 CCF51341.1 - 3.4e-98 328.7 0.0 4e-98 328.5 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 10 LIP PF03583.14 CCF51343.1 - 1e-52 179.3 0.0 1.5e-52 178.7 0.0 1.1 1 0 0 1 1 1 1 Secretory lipase Hydrolase_4 PF12146.8 CCF51343.1 - 0.025 13.8 0.4 0.36 10.1 0.0 2.5 2 1 0 2 2 2 0 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 CCF51343.1 - 0.033 13.6 0.0 0.14 11.6 0.0 1.9 2 0 0 2 2 2 0 Prolyl oligopeptidase family DLH PF01738.18 CCF51343.1 - 0.088 12.4 0.4 2.3 7.7 0.0 2.3 2 0 0 2 2 2 0 Dienelactone hydrolase family PUF PF00806.19 CCF51344.1 - 6.8e-62 201.8 9.9 9.3e-09 34.5 0.0 8.3 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat TetR_C_36 PF18598.1 CCF51345.1 - 0.11 12.5 0.1 0.21 11.5 0.1 1.4 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain Macoilin PF09726.9 CCF51345.1 - 0.96 7.9 8.4 1.5 7.3 8.4 1.4 1 0 0 1 1 1 0 Macoilin family Apt1 PF10351.9 CCF51345.1 - 4.1 6.2 10.7 7.6 5.3 10.7 1.4 1 0 0 1 1 1 0 Golgi-body localisation protein domain RFC1 PF08519.12 CCF51346.1 - 1.6e-49 168.1 0.0 6.8e-48 162.8 0.0 2.5 2 0 0 2 2 2 1 Replication factor RFC1 C terminal domain BRCT PF00533.26 CCF51346.1 - 4e-12 46.4 0.0 9.8e-12 45.1 0.0 1.7 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain AAA PF00004.29 CCF51346.1 - 8.1e-08 32.8 0.0 2.1e-07 31.4 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 CCF51346.1 - 0.00071 19.5 0.0 0.0015 18.4 0.0 1.6 1 0 0 1 1 1 1 NACHT domain Rad17 PF03215.15 CCF51346.1 - 0.0018 18.3 0.0 0.0043 17.0 0.0 1.6 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_22 PF13401.6 CCF51346.1 - 0.0025 18.1 0.0 0.0064 16.8 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.6 CCF51346.1 - 0.0063 16.5 0.0 0.021 14.8 0.0 1.9 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 CCF51346.1 - 0.011 16.1 0.0 0.15 12.5 0.0 2.6 1 1 0 1 1 1 0 RNA helicase AAA_16 PF13191.6 CCF51346.1 - 0.012 16.0 0.0 0.044 14.2 0.0 2.0 1 0 0 1 1 1 0 AAA ATPase domain AAA_18 PF13238.6 CCF51346.1 - 0.033 14.7 0.0 0.11 13.0 0.0 2.0 1 0 0 1 1 1 0 AAA domain RuvB_N PF05496.12 CCF51346.1 - 0.038 13.7 0.0 0.091 12.5 0.0 1.7 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_30 PF13604.6 CCF51346.1 - 0.058 13.1 0.0 0.15 11.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_assoc_2 PF16193.5 CCF51346.1 - 0.088 13.2 0.0 0.3 11.4 0.0 1.9 1 0 0 1 1 1 0 AAA C-terminal domain AAA_7 PF12775.7 CCF51346.1 - 0.12 11.9 0.0 0.28 10.7 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region NTPase_1 PF03266.15 CCF51346.1 - 0.14 12.1 0.0 1.3 9.0 0.0 2.2 2 0 0 2 2 2 0 NTPase Neur_chan_memb PF02932.16 CCF51346.1 - 1.5 8.8 0.0 1.5 8.8 0.0 2.3 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Rgp1 PF08737.10 CCF51347.1 - 3.8e-106 355.8 0.0 6.1e-106 355.1 0.0 1.3 1 0 0 1 1 1 1 Rgp1 Arrestin_N PF00339.29 CCF51347.1 - 9.6e-05 22.5 0.0 0.01 15.9 0.0 3.1 3 0 0 3 3 3 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 CCF51347.1 - 0.0003 21.3 0.3 0.6 10.6 0.0 3.4 3 1 0 3 3 3 2 Arrestin (or S-antigen), C-terminal domain Spo0M PF07070.11 CCF51347.1 - 0.072 12.6 0.0 4.6 6.7 0.0 2.3 2 0 0 2 2 2 0 SpoOM protein Abhydro_lipase PF04083.16 CCF51348.1 - 3.5e-15 55.3 0.0 5.8e-15 54.6 0.0 1.4 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region Abhydrolase_1 PF00561.20 CCF51348.1 - 5.5e-06 26.2 0.2 8.5e-06 25.6 0.2 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CCF51348.1 - 0.074 12.3 0.0 0.14 11.4 0.0 1.4 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Bromodomain PF00439.25 CCF51349.1 - 2.7e-29 101.1 0.2 3.6e-16 59.0 0.0 3.3 2 1 0 2 2 2 2 Bromodomain BET PF17035.5 CCF51349.1 - 1.3e-21 76.5 2.6 3.3e-21 75.2 2.6 1.7 1 0 0 1 1 1 1 Bromodomain extra-terminal - transcription regulation AKNA PF12443.8 CCF51350.1 - 0.067 13.8 8.1 0.031 14.9 4.3 2.4 1 1 1 2 2 2 0 AT-hook-containing transcription factor DUF3584 PF12128.8 CCF51350.1 - 0.078 10.5 26.0 0.11 10.0 26.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DUF2730 PF10805.8 CCF51350.1 - 0.88 9.7 6.6 7.6 6.7 1.4 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF2730) LMBR1 PF04791.16 CCF51350.1 - 1.8 7.3 9.3 3.8 6.3 9.3 1.6 1 0 0 1 1 1 0 LMBR1-like membrane protein RVT_2 PF07727.14 CCF51352.1 - 4.3e-10 39.7 0.1 5.1e-10 39.4 0.1 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1216 PF06746.11 CCF51352.1 - 0.11 12.5 0.0 0.15 12.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1216) rve PF00665.26 CCF51353.1 - 2e-05 24.8 0.1 3.1e-05 24.1 0.1 1.2 1 0 0 1 1 1 1 Integrase core domain CMD PF02627.20 CCF51354.1 - 0.044 13.8 0.3 0.064 13.3 0.3 1.3 1 0 0 1 1 1 0 Carboxymuconolactone decarboxylase family RVT_2 PF07727.14 CCF51357.1 - 1.8e-32 112.9 0.0 2.1e-32 112.7 0.0 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Fructosamin_kin PF03881.14 CCF51358.1 - 1.1e-31 110.1 0.0 1.4e-31 109.8 0.0 1.1 1 0 0 1 1 1 1 Fructosamine kinase APH PF01636.23 CCF51358.1 - 1.7e-05 24.8 0.0 2.6e-05 24.3 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family HECT PF00632.25 CCF51359.1 - 7.4e-98 327.8 0.0 9.6e-98 327.4 0.0 1.1 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) UQ_con PF00179.26 CCF51360.1 - 1.8e-28 98.9 0.0 2.2e-28 98.7 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UEV PF05743.13 CCF51360.1 - 0.012 15.5 0.1 0.018 14.9 0.0 1.3 1 1 0 1 1 1 0 UEV domain UFC1 PF08694.11 CCF51360.1 - 0.089 12.4 0.0 0.14 11.7 0.0 1.4 1 1 0 1 1 1 0 Ubiquitin-fold modifier-conjugating enzyme 1 RWD PF05773.22 CCF51360.1 - 0.15 12.3 0.0 0.21 11.9 0.0 1.5 1 1 0 1 1 1 0 RWD domain Ferrochelatase PF00762.19 CCF51361.1 - 1.3e-106 356.2 0.0 1.6e-106 356.0 0.0 1.0 1 0 0 1 1 1 1 Ferrochelatase CbiX PF01903.17 CCF51361.1 - 0.00038 20.7 0.0 1.4 9.3 0.0 2.5 2 0 0 2 2 2 2 CbiX ORF_12_N PF18042.1 CCF51361.1 - 0.038 14.4 0.7 10 6.6 0.1 2.5 2 0 0 2 2 2 0 ORF 12 gene product N-terminal Synaptobrevin PF00957.21 CCF51362.1 - 5e-32 109.5 2.7 5.8e-32 109.3 2.7 1.0 1 0 0 1 1 1 1 Synaptobrevin DUF5098 PF17023.5 CCF51362.1 - 0.055 12.4 0.3 0.063 12.2 0.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF5098) zf-CCHC PF00098.23 CCF51363.1 - 0.1 12.8 3.2 0.26 11.5 3.2 1.8 1 0 0 1 1 1 0 Zinc knuckle MAPEG PF01124.18 CCF51364.1 - 3e-28 98.3 3.1 3.5e-28 98.1 3.1 1.0 1 0 0 1 1 1 1 MAPEG family zf-4CXXC_R1 PF10497.9 CCF51365.1 - 1.8e-14 53.8 8.0 3.5e-14 52.8 8.0 1.4 1 0 0 1 1 1 1 Zinc-finger domain of monoamine-oxidase A repressor R1 zf-C3HC4_4 PF15227.6 CCF51365.1 - 0.0095 16.1 1.6 0.0095 16.1 1.6 2.1 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING AT_hook PF02178.19 CCF51365.1 - 0.46 10.5 16.8 0.94 9.6 2.5 2.9 2 0 0 2 2 2 0 AT hook motif Pkinase PF00069.25 CCF51366.1 - 2.1e-60 204.3 0.0 1.5e-59 201.5 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF51366.1 - 1.5e-27 96.6 0.2 1.1e-18 67.5 0.0 2.5 3 0 0 3 3 3 2 Protein tyrosine kinase Kinase-like PF14531.6 CCF51366.1 - 6.2e-06 25.7 0.0 0.0034 16.8 0.0 2.3 2 0 0 2 2 2 2 Kinase-like Kdo PF06293.14 CCF51366.1 - 0.0034 16.8 0.0 0.018 14.4 0.0 2.1 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 CCF51366.1 - 0.0035 16.3 0.0 0.0058 15.6 0.0 1.3 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 CCF51366.1 - 0.0042 17.0 1.9 0.058 13.3 0.0 2.8 2 1 1 3 3 3 1 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 CCF51366.1 - 0.11 11.5 0.0 0.19 10.7 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 Pkinase_C PF00433.24 CCF51366.1 - 0.15 12.7 0.3 0.42 11.4 0.0 1.9 2 0 0 2 2 2 0 Protein kinase C terminal domain Spindle_Spc25 PF08234.12 CCF51367.1 - 5.7e-21 74.5 0.3 1.4e-20 73.3 0.0 1.8 2 0 0 2 2 2 1 Chromosome segregation protein Spc25 Spc7 PF08317.11 CCF51367.1 - 0.00074 18.5 13.3 0.00074 18.5 13.3 2.5 2 1 0 2 2 2 1 Spc7 kinetochore protein HAUS-augmin3 PF14932.6 CCF51367.1 - 0.004 16.8 15.8 0.004 16.8 15.8 1.8 2 1 0 2 2 2 1 HAUS augmin-like complex subunit 3 HAP1_N PF04849.13 CCF51367.1 - 0.0056 15.9 13.1 0.011 15.0 13.1 1.4 1 0 0 1 1 1 1 HAP1 N-terminal conserved region Dynamitin PF04912.14 CCF51367.1 - 0.019 14.3 10.9 0.017 14.5 9.3 1.5 1 1 0 1 1 1 0 Dynamitin DNA_pol_B PF00136.21 CCF51367.1 - 0.027 13.2 2.0 0.031 13.0 1.4 1.4 1 1 0 1 1 1 0 DNA polymerase family B DUF1515 PF07439.11 CCF51367.1 - 0.042 13.9 0.4 0.042 13.9 0.4 2.5 3 1 1 4 4 3 0 Protein of unknown function (DUF1515) Golgin_A5 PF09787.9 CCF51367.1 - 0.044 13.3 12.1 0.079 12.4 12.1 1.4 1 0 0 1 1 1 0 Golgin subfamily A member 5 DUF5082 PF16888.5 CCF51367.1 - 0.05 13.9 12.0 0.63 10.3 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF5082) DUF1192 PF06698.11 CCF51367.1 - 0.06 13.4 1.3 0.06 13.4 1.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) UPF0242 PF06785.11 CCF51367.1 - 0.19 11.8 15.3 0.054 13.6 12.4 1.5 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Cortex-I_coil PF09304.10 CCF51367.1 - 0.27 11.5 19.9 0.058 13.6 14.7 2.2 2 0 0 2 2 2 0 Cortexillin I, coiled coil FapA PF03961.13 CCF51367.1 - 0.38 9.3 10.9 0.057 12.0 7.2 1.5 2 0 0 2 2 2 0 Flagellar Assembly Protein A Atg14 PF10186.9 CCF51367.1 - 0.41 9.7 16.6 0.63 9.1 15.6 1.7 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 CALCOCO1 PF07888.11 CCF51367.1 - 0.46 9.3 22.5 0.85 8.4 22.4 1.5 1 1 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like V_ATPase_I PF01496.19 CCF51367.1 - 0.96 7.3 6.4 1.2 7.0 6.4 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Syntaxin-6_N PF09177.11 CCF51367.1 - 1.1 9.8 12.5 0.61 10.7 3.5 2.8 2 1 1 3 3 3 0 Syntaxin 6, N-terminal DUF2968 PF11180.8 CCF51367.1 - 1.8 8.2 23.0 0.27 10.8 17.7 2.2 2 1 1 3 3 3 0 Protein of unknown function (DUF2968) TMPIT PF07851.13 CCF51367.1 - 2.7 7.1 10.6 1.7 7.8 8.9 1.6 1 1 1 2 2 2 0 TMPIT-like protein HIP1_clath_bdg PF16515.5 CCF51367.1 - 3.2 8.4 23.4 2.6 8.7 4.0 2.9 2 1 1 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 TPR_MLP1_2 PF07926.12 CCF51367.1 - 4 7.5 28.1 3.2 7.8 22.3 2.4 2 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein FUSC PF04632.12 CCF51367.1 - 4.8 5.6 8.7 0.54 8.7 4.8 1.3 2 0 0 2 2 2 0 Fusaric acid resistance protein family Phage_GPO PF05929.11 CCF51367.1 - 6 6.4 12.6 20 4.7 11.9 1.8 1 1 1 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase Ax_dynein_light PF10211.9 CCF51367.1 - 8.3 6.3 21.2 14 5.6 0.6 2.5 2 1 1 3 3 3 0 Axonemal dynein light chain TPK_catalytic PF04263.16 CCF51368.1 - 3.2e-30 104.6 0.0 6.3e-30 103.7 0.0 1.4 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, catalytic domain TPK_B1_binding PF04265.14 CCF51368.1 - 6.4e-18 64.2 0.0 1.1e-17 63.4 0.0 1.4 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, vitamin B1 binding domain Lactamase_B_2 PF12706.7 CCF51368.1 - 8.8e-10 38.4 0.1 6.5e-07 29.1 0.0 3.4 4 0 0 4 4 4 2 Beta-lactamase superfamily domain Lactamase_B PF00753.27 CCF51368.1 - 1.3e-07 31.9 0.0 3.1e-07 30.6 0.0 1.6 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_6 PF16661.5 CCF51368.1 - 0.015 14.7 0.0 0.024 14.1 0.0 1.2 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily domain Lactamase_B_4 PF13691.6 CCF51368.1 - 0.048 13.3 0.0 0.13 12.0 0.0 1.7 1 0 0 1 1 1 0 tRNase Z endonuclease Septin PF00735.18 CCF51369.1 - 5.9e-109 363.7 0.8 7.1e-109 363.4 0.0 1.4 2 0 0 2 2 2 1 Septin MMR_HSR1 PF01926.23 CCF51369.1 - 4.7e-08 33.1 0.0 1.4e-07 31.6 0.0 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 CCF51369.1 - 3.8e-05 23.3 0.3 0.004 16.7 0.0 2.4 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 CCF51369.1 - 0.00013 22.0 0.8 0.012 15.5 0.9 3.0 2 1 0 2 2 2 1 RsgA GTPase Dynamin_N PF00350.23 CCF51369.1 - 0.00047 20.3 5.5 0.029 14.4 0.1 3.2 2 1 1 3 3 3 2 Dynamin family AIG1 PF04548.16 CCF51369.1 - 0.0043 16.4 0.0 0.0085 15.4 0.0 1.5 1 0 0 1 1 1 1 AIG1 family AAA_33 PF13671.6 CCF51369.1 - 0.0046 17.1 0.0 0.015 15.5 0.0 1.9 1 0 0 1 1 1 1 AAA domain FtsK_SpoIIIE PF01580.18 CCF51369.1 - 0.0046 16.3 0.3 0.0093 15.3 0.3 1.5 1 0 0 1 1 1 1 FtsK/SpoIIIE family AAA_28 PF13521.6 CCF51369.1 - 0.0058 16.9 5.0 0.042 14.1 0.7 3.1 2 1 0 2 2 2 1 AAA domain IIGP PF05049.13 CCF51369.1 - 0.011 14.8 1.5 0.015 14.4 0.1 1.8 2 1 0 2 2 2 0 Interferon-inducible GTPase (IIGP) AAA_16 PF13191.6 CCF51369.1 - 0.012 16.0 1.4 0.014 15.8 0.1 2.0 2 1 0 2 2 2 0 AAA ATPase domain AAA_22 PF13401.6 CCF51369.1 - 0.017 15.4 0.1 0.017 15.4 0.1 2.4 2 2 0 2 2 2 0 AAA domain TniB PF05621.11 CCF51369.1 - 0.026 13.9 0.0 1.9 7.9 0.0 2.5 2 0 0 2 2 2 0 Bacterial TniB protein AAA_19 PF13245.6 CCF51369.1 - 0.027 14.8 0.1 0.13 12.6 0.1 2.0 2 1 0 2 2 2 0 AAA domain AAA_23 PF13476.6 CCF51369.1 - 0.028 14.9 9.0 1.6 9.2 4.3 2.3 2 1 0 2 2 2 0 AAA domain Roc PF08477.13 CCF51369.1 - 0.028 14.6 0.0 0.065 13.5 0.0 1.6 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_24 PF13479.6 CCF51369.1 - 0.031 14.0 0.0 0.055 13.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 CCF51369.1 - 0.051 14.1 3.4 0.3 11.6 0.0 3.1 2 1 1 3 3 3 0 AAA domain ABC_tran PF00005.27 CCF51369.1 - 0.079 13.5 1.7 0.19 12.2 1.7 2.1 1 1 0 1 1 1 0 ABC transporter RNA_helicase PF00910.22 CCF51369.1 - 0.1 13.0 0.0 0.2 12.1 0.0 1.5 1 0 0 1 1 1 0 RNA helicase Ras PF00071.22 CCF51369.1 - 0.13 11.9 1.0 0.4 10.3 0.0 2.2 2 0 0 2 2 2 0 Ras family Pox_A32 PF04665.12 CCF51369.1 - 0.14 11.6 0.0 0.24 10.8 0.0 1.3 1 0 0 1 1 1 0 Poxvirus A32 protein DUF87 PF01935.17 CCF51369.1 - 0.78 9.8 6.3 1.1 9.3 0.2 2.3 2 0 0 2 2 2 0 Helicase HerA, central domain AAA_18 PF13238.6 CCF51370.1 - 4.2e-24 85.6 0.0 7.8e-24 84.7 0.0 1.4 1 1 0 1 1 1 1 AAA domain AAA_28 PF13521.6 CCF51370.1 - 0.00019 21.7 2.6 0.0018 18.6 2.5 2.4 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 CCF51370.1 - 0.001 19.4 0.0 0.0017 18.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain Thymidylate_kin PF02223.17 CCF51370.1 - 0.011 15.4 0.0 0.13 12.0 0.0 2.0 2 0 0 2 2 2 0 Thymidylate kinase ADK PF00406.22 CCF51370.1 - 0.022 14.8 0.4 0.78 9.8 0.1 2.4 2 1 0 2 2 2 0 Adenylate kinase NTPase_1 PF03266.15 CCF51370.1 - 0.029 14.3 0.8 0.087 12.7 0.2 2.1 3 0 0 3 3 3 0 NTPase AAA_30 PF13604.6 CCF51370.1 - 0.035 13.8 0.0 0.15 11.8 0.0 1.8 2 0 0 2 2 2 0 AAA domain KTI12 PF08433.10 CCF51370.1 - 0.035 13.5 0.0 0.056 12.9 0.0 1.4 1 0 0 1 1 1 0 Chromatin associated protein KTI12 AAA_33 PF13671.6 CCF51370.1 - 0.036 14.2 0.5 3.4 7.8 0.1 2.8 2 1 0 2 2 2 0 AAA domain dNK PF01712.19 CCF51370.1 - 0.064 13.1 0.0 11 5.8 0.0 2.2 2 0 0 2 2 2 0 Deoxynucleoside kinase AAA_17 PF13207.6 CCF51370.1 - 0.081 13.3 0.1 6.5 7.2 0.1 2.5 2 1 0 2 2 2 0 AAA domain FtsK_SpoIIIE PF01580.18 CCF51370.1 - 0.082 12.2 0.3 0.38 10.1 0.1 1.9 2 0 0 2 2 2 0 FtsK/SpoIIIE family ATPase PF06745.13 CCF51370.1 - 0.094 12.0 0.1 0.45 9.8 0.0 1.9 2 0 0 2 2 2 0 KaiC MeaB PF03308.16 CCF51370.1 - 0.1 11.6 0.1 0.23 10.4 0.1 1.5 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_16 PF13191.6 CCF51370.1 - 0.11 12.8 0.0 0.15 12.5 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain AAA_24 PF13479.6 CCF51370.1 - 0.17 11.6 0.0 0.27 10.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain NMO PF03060.15 CCF51371.1 - 1.3e-52 179.2 0.3 2e-52 178.7 0.3 1.3 1 0 0 1 1 1 1 Nitronate monooxygenase IMPDH PF00478.25 CCF51371.1 - 7.5e-12 44.9 1.6 1.4e-11 44.0 1.6 1.4 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain FMN_dh PF01070.18 CCF51371.1 - 0.0034 16.5 3.3 0.0055 15.8 3.3 1.3 1 0 0 1 1 1 1 FMN-dependent dehydrogenase LSM PF01423.22 CCF51372.1 - 2e-09 37.0 0.0 2.7e-09 36.6 0.0 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 CCF51372.1 - 7.4e-05 22.8 0.0 0.00012 22.2 0.0 1.3 1 0 0 1 1 1 1 Ataxin 2 SM domain ABC_tran PF00005.27 CCF51374.1 - 2e-48 164.4 0.2 2.6e-23 83.0 0.0 2.8 3 0 0 3 3 3 2 ABC transporter ABC2_membrane_3 PF12698.7 CCF51374.1 - 8.5e-21 74.4 27.7 3.7e-13 49.3 7.1 2.6 2 1 0 2 2 2 2 ABC-2 family transporter protein AAA_21 PF13304.6 CCF51374.1 - 1.4e-10 41.5 13.1 0.00039 20.3 0.0 4.7 5 0 0 5 5 5 3 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CCF51374.1 - 5.5e-06 26.0 0.0 0.11 11.9 0.0 3.5 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CCF51374.1 - 0.002 17.8 0.7 0.076 12.8 0.1 2.6 2 0 0 2 2 2 1 P-loop containing region of AAA domain SRP54 PF00448.22 CCF51374.1 - 0.034 13.8 2.4 4.4 6.9 0.2 2.3 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain MukB PF04310.12 CCF51374.1 - 0.064 13.1 1.3 5.2 6.8 0.0 2.6 2 0 0 2 2 2 0 MukB N-terminal AAA_23 PF13476.6 CCF51374.1 - 0.14 12.7 1.7 1.1 9.7 0.2 2.5 3 0 0 3 3 3 0 AAA domain SbcCD_C PF13558.6 CCF51374.1 - 0.15 12.3 1.0 5.5 7.3 0.1 3.7 3 1 0 3 3 3 0 Putative exonuclease SbcCD, C subunit IstB_IS21 PF01695.17 CCF51374.1 - 0.22 11.3 0.6 15 5.2 0.0 3.3 4 0 0 4 4 4 0 IstB-like ATP binding protein RVT_2 PF07727.14 CCF51376.1 - 5.7e-36 124.4 0.2 6.6e-36 124.2 0.2 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF3328 PF11807.8 CCF51378.1 - 0.068 12.9 0.1 0.084 12.6 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3328) UL42 PF17638.2 CCF51378.1 - 0.07 13.1 0.7 0.11 12.5 0.7 1.4 1 0 0 1 1 1 0 HCMV UL42 Peripla_BP_7 PF18610.1 CCF51380.1 - 0.0082 16.2 0.0 0.034 14.3 0.0 1.9 2 0 0 2 2 2 1 Periplasmic binding protein domain Pkr1 PF08636.10 CCF51381.1 - 1.5e-26 92.3 7.0 1.8e-26 92.1 7.0 1.1 1 0 0 1 1 1 1 ER protein Pkr1 UPF0154 PF03672.13 CCF51381.1 - 0.014 15.4 0.3 0.036 14.1 0.3 1.6 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0154) DLIC PF05783.11 CCF51382.1 - 1.8e-50 172.2 19.1 8.2e-28 97.5 0.0 7.0 5 2 1 7 7 7 6 Dynein light intermediate chain (DLIC) FAM27 PF15832.5 CCF51382.1 - 0.0041 17.6 1.3 0.014 15.9 1.3 1.9 1 0 0 1 1 1 1 FAM27 D and E protein family AAA_16 PF13191.6 CCF51382.1 - 0.0046 17.4 1.2 0.0046 17.4 1.2 2.8 3 1 0 3 3 3 1 AAA ATPase domain DUF442 PF04273.13 CCF51382.1 - 0.015 15.4 2.5 0.55 10.3 0.2 2.9 2 0 0 2 2 2 0 Putative phosphatase (DUF442) MCM PF00493.23 CCF51382.1 - 0.041 13.0 0.1 0.21 10.6 0.0 2.0 2 0 0 2 2 2 0 MCM P-loop domain RsgA_GTPase PF03193.16 CCF51382.1 - 0.05 13.5 0.2 2.4 8.1 0.1 2.4 2 0 0 2 2 2 0 RsgA GTPase DUF4179 PF13786.6 CCF51382.1 - 0.08 13.4 0.4 1.8 9.1 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4179) DUF3915 PF13054.6 CCF51382.1 - 0.11 12.5 4.7 0.053 13.5 1.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3915) G-alpha PF00503.20 CCF51382.1 - 0.49 9.5 3.4 1.7 7.7 0.2 2.5 3 0 0 3 3 3 0 G-protein alpha subunit DUF2939 PF11159.8 CCF51382.1 - 7.7 7.0 8.2 0.58 10.6 0.9 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2939) IPP-2 PF04979.14 CCF51383.1 - 3.2e-17 63.5 8.9 6.4e-16 59.3 8.9 2.2 1 1 0 1 1 1 1 Protein phosphatase inhibitor 2 (IPP-2) Tub_N PF16322.5 CCF51383.1 - 2.8 8.3 14.8 2.9 8.2 10.8 2.1 1 1 1 2 2 2 0 Tubby N-terminal CDC45 PF02724.14 CCF51384.1 - 1.1 7.5 14.4 0.66 8.2 0.3 2.1 2 0 0 2 2 2 0 CDC45-like protein LNS2 PF08235.13 CCF51385.1 - 5.7e-100 333.4 0.0 2.9e-77 259.2 0.0 2.2 1 1 1 2 2 2 2 LNS2 (Lipin/Ned1/Smp2) Lipin_N PF04571.14 CCF51385.1 - 4.6e-28 97.2 0.3 9.7e-18 64.0 0.0 2.5 2 0 0 2 2 2 2 lipin, N-terminal conserved region Lipin_mid PF16876.5 CCF51385.1 - 1.6e-18 66.7 0.0 3.7e-18 65.5 0.0 1.7 1 0 0 1 1 1 1 Lipin/Ned1/Smp2 multi-domain protein middle domain CN_hydrolase PF00795.22 CCF51386.1 - 4.5e-16 59.0 0.0 1.1e-05 24.9 0.0 3.0 3 0 0 3 3 3 3 Carbon-nitrogen hydrolase YlbD_coat PF14071.6 CCF51386.1 - 0.018 15.3 0.0 0.042 14.1 0.0 1.5 1 0 0 1 1 1 0 Putative coat protein Peptidase_S10 PF00450.22 CCF51387.1 - 1.1e-100 337.9 0.0 1.4e-100 337.6 0.0 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase Myb_DNA-binding PF00249.31 CCF51388.1 - 8.9e-27 93.0 7.2 3.4e-12 46.3 0.4 6.1 5 1 0 5 5 5 5 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 CCF51388.1 - 6e-21 74.5 0.0 1.8e-06 28.1 0.0 5.4 3 1 2 5 5 5 4 Myb-like DNA-binding domain Myb_DNA-bind_4 PF13837.6 CCF51388.1 - 0.00032 21.0 0.3 9.8 6.6 0.1 4.0 3 0 0 3 3 3 2 Myb/SANT-like DNA-binding domain TAF1D PF15333.6 CCF51388.1 - 0.013 15.3 0.0 0.031 14.0 0.0 1.6 1 0 0 1 1 1 0 TATA box-binding protein-associated factor 1D FXMRP1_C_core PF12235.8 CCF51388.1 - 0.038 14.6 4.0 0.05 14.2 0.5 2.6 2 0 0 2 2 2 0 Fragile X-related 1 protein core C terminal Ribosomal_S7 PF00177.21 CCF51389.1 - 2e-36 124.9 0.2 3.9e-36 123.9 0.2 1.4 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e Ebp2 PF05890.12 CCF51389.1 - 0.11 12.0 0.9 0.21 11.1 0.9 1.4 1 0 0 1 1 1 0 Eukaryotic rRNA processing protein EBP2 SUR7 PF06687.12 CCF51390.1 - 4.4e-18 65.7 5.2 6.2e-18 65.2 5.2 1.1 1 0 0 1 1 1 1 SUR7/PalI family DUF2254 PF10011.9 CCF51390.1 - 0.0029 16.5 0.2 0.0029 16.5 0.2 1.7 2 0 0 2 2 2 1 Predicted membrane protein (DUF2254) Claudin_2 PF13903.6 CCF51390.1 - 0.0036 17.1 0.6 0.0053 16.5 0.6 1.3 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction RseC_MucC PF04246.12 CCF51390.1 - 0.099 12.6 0.5 0.21 11.6 0.5 1.5 1 0 0 1 1 1 0 Positive regulator of sigma(E), RseC/MucC NDUF_B12 PF08122.12 CCF51390.1 - 1.2 9.3 2.8 12 6.1 0.2 2.8 2 1 1 3 3 3 0 NADH-ubiquinone oxidoreductase B12 subunit family Phosphodiest PF01663.22 CCF51391.1 - 7.8e-11 42.1 0.4 1.3e-10 41.4 0.4 1.3 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Metalloenzyme PF01676.18 CCF51391.1 - 0.01 15.2 1.0 0.018 14.4 1.0 1.3 1 0 0 1 1 1 0 Metalloenzyme superfamily Cation_ATPase_C PF00689.21 CCF51392.1 - 1.2e-46 158.7 9.8 1.2e-46 158.7 9.8 2.3 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 CCF51392.1 - 4.6e-38 130.6 0.0 1.2e-37 129.1 0.0 1.8 1 0 0 1 1 1 1 E1-E2 ATPase Cation_ATPase PF13246.6 CCF51392.1 - 1e-19 70.4 0.1 2e-19 69.5 0.1 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 CCF51392.1 - 1.5e-17 64.6 0.6 4.6e-17 63.0 0.6 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 CCF51392.1 - 2.9e-07 30.1 0.9 9.3e-07 28.5 0.1 2.3 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 CCF51392.1 - 0.00074 19.3 0.2 0.022 14.5 0.3 2.3 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase DUF1373 PF07117.11 CCF51392.1 - 0.098 12.6 0.6 0.7 9.8 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1373) PrgI PF12666.7 CCF51392.1 - 0.47 11.2 4.4 19 6.0 0.0 3.8 3 0 0 3 3 3 0 PrgI family protein CENP-B_dimeris PF09026.10 CCF51395.1 - 0.0048 17.2 2.4 0.0068 16.8 2.4 1.3 1 0 0 1 1 1 1 Centromere protein B dimerisation domain PBP1_TM PF14812.6 CCF51395.1 - 0.008 16.5 4.0 0.011 16.1 4.0 1.3 1 0 0 1 1 1 1 Transmembrane domain of transglycosylase PBP1 at N-terminal NOA36 PF06524.12 CCF51395.1 - 0.016 14.5 2.6 0.018 14.4 2.6 1.1 1 0 0 1 1 1 0 NOA36 protein Pox_Ag35 PF03286.14 CCF51395.1 - 0.021 14.6 5.5 0.024 14.4 5.5 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Eapp_C PF10238.9 CCF51395.1 - 0.025 14.7 1.8 0.027 14.5 1.8 1.1 1 0 0 1 1 1 0 E2F-associated phosphoprotein DGF-1_C PF11040.8 CCF51395.1 - 0.039 14.0 2.2 0.048 13.7 1.5 1.5 1 1 0 1 1 1 0 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DUF4611 PF15387.6 CCF51395.1 - 0.067 13.4 6.2 0.088 13.0 6.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) PGA2 PF07543.12 CCF51395.1 - 0.085 12.8 5.0 0.095 12.7 5.0 1.1 1 0 0 1 1 1 0 Protein trafficking PGA2 FAM176 PF14851.6 CCF51395.1 - 0.086 12.5 9.3 0.089 12.5 8.7 1.3 1 1 0 1 1 1 0 FAM176 family Myc_N PF01056.18 CCF51395.1 - 0.096 12.6 4.9 0.1 12.5 4.9 1.1 1 0 0 1 1 1 0 Myc amino-terminal region PPL5 PF18168.1 CCF51395.1 - 0.15 11.4 1.9 0.16 11.2 1.9 1.0 1 0 0 1 1 1 0 Prim-pol family 5 SPATIAL PF15256.6 CCF51395.1 - 0.15 12.4 2.3 0.17 12.2 2.3 1.1 1 0 0 1 1 1 0 SPATIAL DUF4746 PF15928.5 CCF51395.1 - 0.21 11.0 7.7 0.22 10.9 7.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Radial_spoke PF04712.12 CCF51395.1 - 0.34 9.8 8.5 0.36 9.7 8.5 1.1 1 0 0 1 1 1 0 Radial spokehead-like protein DNA_pol_phi PF04931.13 CCF51395.1 - 0.39 8.7 5.8 0.38 8.8 5.8 1.1 1 0 0 1 1 1 0 DNA polymerase phi BT1 PF03092.16 CCF51395.1 - 1.8 6.7 2.7 2 6.5 2.7 1.0 1 0 0 1 1 1 0 BT1 family Presenilin PF01080.17 CCF51395.1 - 4.3 6.0 4.3 4.6 5.9 4.3 1.1 1 0 0 1 1 1 0 Presenilin MFS_1 PF07690.16 CCF51396.1 - 4.2e-32 111.4 26.1 5.8e-32 111.0 26.1 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily TIP120 PF08623.10 CCF51397.1 - 7.6e-54 182.0 4.9 2.9e-52 176.9 0.2 4.1 4 1 1 5 5 5 1 TATA-binding protein interacting (TIP20) HEAT_2 PF13646.6 CCF51397.1 - 2.4e-19 69.5 21.8 0.0003 21.1 0.1 10.2 6 5 3 9 9 9 5 HEAT repeats HEAT_EZ PF13513.6 CCF51397.1 - 1.5e-15 57.3 31.0 0.0094 16.4 0.0 11.4 11 1 1 12 12 12 6 HEAT-like repeat HEAT PF02985.22 CCF51397.1 - 1.4e-14 52.9 32.7 0.31 11.4 0.1 14.2 15 0 0 15 15 15 5 HEAT repeat Cnd3 PF12719.7 CCF51397.1 - 1.8e-05 24.1 5.6 0.27 10.4 0.1 5.2 4 2 1 5 5 5 2 Nuclear condensing complex subunits, C-term domain Cnd1 PF12717.7 CCF51397.1 - 1.8e-05 24.8 15.5 0.0084 16.2 3.3 5.2 5 1 1 7 7 7 2 non-SMC mitotic condensation complex subunit 1 MMS19_N PF14500.6 CCF51397.1 - 0.0023 17.5 12.5 0.033 13.8 0.9 5.2 4 2 0 4 4 4 1 Dos2-interacting transcription regulator of RNA-Pol-II V-ATPase_H_C PF11698.8 CCF51397.1 - 0.12 12.5 7.3 1.9 8.6 0.9 4.7 3 1 2 5 5 5 0 V-ATPase subunit H DUF3361 PF11841.8 CCF51397.1 - 0.71 9.8 6.8 0.28 11.1 0.3 3.7 4 1 0 4 4 4 0 Domain of unknown function (DUF3361) PCI PF01399.27 CCF51398.1 - 1e-05 25.9 0.0 2.3e-05 24.8 0.0 1.6 1 0 0 1 1 1 1 PCI domain TPR_16 PF13432.6 CCF51398.1 - 0.013 16.1 0.7 0.05 14.3 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.17 CCF51398.1 - 4.9 7.5 6.2 0.87 9.9 0.3 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat PEN-2 PF10251.9 CCF51399.1 - 0.012 16.0 0.0 0.025 15.0 0.0 1.4 1 0 0 1 1 1 0 Presenilin enhancer-2 subunit of gamma secretase TEX13 PF15186.6 CCF51399.1 - 0.46 10.1 6.1 1.4 8.6 6.1 1.8 1 0 0 1 1 1 0 Testis-expressed sequence 13 protein family MutL_C PF08676.11 CCF51401.1 - 2.1e-09 37.3 0.0 1.1e-07 31.7 0.0 2.4 2 0 0 2 2 2 2 MutL C terminal dimerisation domain Linker_histone PF00538.19 CCF51402.1 - 1.5e-19 70.1 0.2 1.5e-19 70.1 0.2 2.0 2 0 0 2 2 2 1 linker histone H1 and H5 family HC2 PF07382.11 CCF51402.1 - 0.0012 19.0 72.6 0.0032 17.6 56.5 2.2 1 1 1 2 2 2 2 Histone H1-like nucleoprotein HC2 RESP18 PF14948.6 CCF51402.1 - 2 8.7 5.2 0.77 10.1 0.1 2.2 1 1 1 2 2 2 0 RESP18 domain Herpes_UL17 PF04559.12 CCF51402.1 - 6.7 5.4 7.9 7.8 5.2 7.9 1.1 1 0 0 1 1 1 0 Herpesvirus UL17 protein Adap_comp_sub PF00928.21 CCF51403.1 - 3.4e-93 311.8 0.0 7.2e-93 310.8 0.0 1.5 2 0 0 2 2 2 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 CCF51403.1 - 7.1e-07 29.3 0.2 1.2e-06 28.5 0.2 1.4 1 0 0 1 1 1 1 Clathrin adaptor complex small chain muHD PF10291.9 CCF51403.1 - 0.051 13.0 0.0 0.089 12.2 0.0 1.4 1 0 0 1 1 1 0 Muniscin C-terminal mu homology domain PA_decarbox PF05870.11 CCF51404.1 - 7.2e-10 38.7 0.1 8e-10 38.6 0.1 1.2 1 0 0 1 1 1 1 Phenolic acid decarboxylase (PAD) ParA PF10609.9 CCF51405.1 - 2.8e-88 295.5 0.0 3.7e-88 295.1 0.0 1.1 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 CCF51405.1 - 1.7e-05 24.9 1.3 0.00012 22.2 1.3 2.6 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 CCF51405.1 - 5.8e-05 23.1 0.1 0.029 14.3 0.1 2.4 2 0 0 2 2 2 2 AAA domain ArsA_ATPase PF02374.15 CCF51405.1 - 0.00024 20.4 0.2 0.00024 20.4 0.2 2.6 3 1 0 3 3 3 1 Anion-transporting ATPase AAA_25 PF13481.6 CCF51405.1 - 0.014 15.0 0.1 0.024 14.2 0.1 1.5 1 0 0 1 1 1 0 AAA domain MipZ PF09140.11 CCF51405.1 - 0.018 14.3 0.0 0.052 12.8 0.0 1.7 1 1 0 1 1 1 0 ATPase MipZ AAA_26 PF13500.6 CCF51405.1 - 0.036 13.9 0.0 3.4 7.4 0.0 2.4 2 0 0 2 2 2 0 AAA domain zf-C4_ClpX PF06689.13 CCF51405.1 - 0.049 13.5 0.5 0.095 12.6 0.5 1.4 1 0 0 1 1 1 0 ClpX C4-type zinc finger NB-ARC PF00931.22 CCF51405.1 - 0.21 10.8 0.7 0.36 10.0 0.0 1.6 2 0 0 2 2 2 0 NB-ARC domain AAA_16 PF13191.6 CCF51405.1 - 0.38 11.1 3.7 0.89 9.9 0.5 2.4 2 1 0 2 2 2 0 AAA ATPase domain LapA_dom PF06305.11 CCF51406.1 - 0.039 13.8 0.1 0.073 12.9 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain Tubulin-binding PF00418.19 CCF51406.1 - 0.054 13.5 0.0 0.13 12.3 0.0 1.6 1 0 0 1 1 1 0 Tau and MAP protein, tubulin-binding repeat EMP24_GP25L PF01105.24 CCF51408.1 - 6.6e-47 159.8 0.0 7.6e-47 159.6 0.0 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Voltage_CLC PF00654.20 CCF51409.1 - 8.5e-91 304.8 28.2 1.6e-90 303.9 28.2 1.4 1 0 0 1 1 1 1 Voltage gated chloride channel CBS PF00571.28 CCF51409.1 - 9.7e-08 32.3 0.1 6.4e-05 23.3 0.0 3.1 3 0 0 3 3 3 2 CBS domain Pro_isomerase PF00160.21 CCF51410.1 - 1.1e-27 97.2 0.0 2.7e-27 96.0 0.0 1.7 1 1 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD RRM_1 PF00076.22 CCF51410.1 - 3.2e-16 58.9 0.0 7.4e-16 57.7 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Oxysterol_BP PF01237.18 CCF51411.1 - 4.7e-67 226.4 0.3 1.7e-64 218.0 0.3 2.0 1 1 0 1 1 1 1 Oxysterol-binding protein Pkinase PF00069.25 CCF51412.1 - 1.8e-55 188.2 0.0 1.1e-54 185.6 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF51412.1 - 6.4e-27 94.5 0.0 1.2e-21 77.2 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 CCF51412.1 - 1.7e-06 27.6 0.0 3e-06 26.8 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 CCF51412.1 - 0.01 15.8 0.1 0.031 14.2 0.0 1.8 2 0 0 2 2 2 0 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 CCF51412.1 - 0.14 11.2 0.0 0.22 10.5 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Pro_isomerase PF00160.21 CCF51413.1 - 6.9e-35 120.7 0.0 7.9e-35 120.5 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD PCI PF01399.27 CCF51414.1 - 0.016 15.7 0.0 0.034 14.7 0.0 1.6 1 0 0 1 1 1 0 PCI domain DUF148 PF02520.17 CCF51414.1 - 0.022 14.9 4.9 0.038 14.1 4.9 1.3 1 0 0 1 1 1 0 Domain of unknown function DUF148 DUF4618 PF15397.6 CCF51414.1 - 0.055 12.9 0.5 0.055 12.9 0.5 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4618) Spc7 PF08317.11 CCF51414.1 - 1.5 7.6 8.2 0.56 9.0 5.4 1.6 2 0 0 2 2 2 0 Spc7 kinetochore protein Choline_transpo PF04515.12 CCF51415.1 - 1.4e-60 205.2 10.8 4.1e-34 118.2 0.0 2.8 3 0 0 3 3 3 2 Plasma-membrane choline transporter TFIIA PF03153.13 CCF51415.1 - 2.3 8.1 14.1 3.6 7.5 14.1 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit GrpE PF01025.19 CCF51416.1 - 9.1e-45 152.3 0.1 1.3e-44 151.8 0.1 1.3 1 1 0 1 1 1 1 GrpE DUF4201 PF13870.6 CCF51416.1 - 0.007 16.1 1.6 0.01 15.6 1.6 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4201) PKcGMP_CC PF16808.5 CCF51416.1 - 2.5 8.0 7.0 0.18 11.7 1.5 2.0 2 0 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase RRM_1 PF00076.22 CCF51417.1 - 4e-78 257.2 0.5 7.9e-20 70.5 0.2 4.2 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP PF00658.18 CCF51417.1 - 5e-27 93.9 1.0 3.9e-26 91.0 1.4 2.3 3 0 0 3 3 2 1 Poly-adenylate binding protein, unique domain RRM_5 PF13893.6 CCF51417.1 - 2.1e-10 40.3 0.3 0.11 12.1 0.0 4.2 2 1 1 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 CCF51417.1 - 0.00035 20.6 2.3 0.14 12.2 1.5 3.2 3 0 0 3 3 3 1 RNA binding motif YflT PF11181.8 CCF51417.1 - 0.00046 20.7 1.0 0.019 15.5 0.2 2.6 2 0 0 2 2 2 1 Heat induced stress protein YflT RRM_occluded PF16842.5 CCF51417.1 - 0.0028 17.5 0.0 0.036 13.9 0.0 2.6 2 0 0 2 2 2 1 Occluded RNA-recognition motif RRM_7 PF16367.5 CCF51417.1 - 0.0056 16.8 0.2 24 5.1 0.0 4.3 3 1 1 4 4 4 0 RNA recognition motif Nup35_RRM_2 PF14605.6 CCF51417.1 - 0.0077 16.2 0.4 13 5.9 0.0 3.6 4 0 0 4 4 4 1 Nup53/35/40-type RNA recognition motif CbiG_mid PF11761.8 CCF51417.1 - 0.026 14.6 0.0 11 6.2 0.0 3.0 3 0 0 3 3 3 0 Cobalamin biosynthesis central region Calcipressin PF04847.12 CCF51417.1 - 0.046 13.5 0.1 0.14 11.9 0.1 1.8 1 0 0 1 1 1 0 Calcipressin Limkain-b1 PF11608.8 CCF51417.1 - 0.09 12.9 0.3 2.4 8.3 0.1 3.2 4 0 0 4 4 4 0 Limkain b1 OB_RNB PF08206.11 CCF51417.1 - 0.14 11.9 1.7 6.3 6.6 0.4 3.2 3 0 0 3 3 3 0 Ribonuclease B OB domain KH_8 PF17903.1 CCF51418.1 - 0.026 14.6 0.0 0.045 13.8 0.0 1.3 1 0 0 1 1 1 0 Krr1 KH1 domain KH_1 PF00013.29 CCF51418.1 - 0.052 13.4 0.7 0.11 12.4 0.7 1.5 1 0 0 1 1 1 0 KH domain DUF4357 PF14267.6 CCF51418.1 - 4.9 7.2 7.1 9.5 6.3 0.3 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4357) RAP1 PF07218.11 CCF51418.1 - 7.2 4.8 10.3 17 3.5 10.3 1.6 1 1 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) AAA_22 PF13401.6 CCF51419.1 - 3.7e-17 62.9 0.8 1.6e-16 60.8 0.0 2.3 2 1 0 2 2 2 1 AAA domain AAA PF00004.29 CCF51419.1 - 1.3e-09 38.6 0.0 3.1e-09 37.3 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) TniB PF05621.11 CCF51419.1 - 3.5e-08 33.1 0.0 6.1e-08 32.3 0.0 1.4 1 0 0 1 1 1 1 Bacterial TniB protein NACHT PF05729.12 CCF51419.1 - 3.2e-07 30.4 0.0 9.8e-07 28.8 0.0 1.8 2 0 0 2 2 2 1 NACHT domain AAA_16 PF13191.6 CCF51419.1 - 5.3e-06 26.9 0.7 5.3e-06 26.9 0.7 3.4 2 2 0 2 2 2 1 AAA ATPase domain NB-ARC PF00931.22 CCF51419.1 - 7.8e-05 22.0 0.0 0.00014 21.1 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain AAA_33 PF13671.6 CCF51419.1 - 0.007 16.5 0.0 0.026 14.7 0.0 2.1 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 CCF51419.1 - 0.023 15.0 0.0 0.14 12.4 0.0 2.3 2 0 0 2 2 2 0 AAA domain NTPase_1 PF03266.15 CCF51419.1 - 0.028 14.3 0.0 0.41 10.6 0.0 2.3 2 0 0 2 2 2 0 NTPase ATPase_2 PF01637.18 CCF51419.1 - 0.032 14.2 0.0 0.4 10.5 0.0 2.2 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_lid_10 PF17872.1 CCF51419.1 - 0.033 14.3 0.3 0.089 12.9 0.2 1.8 2 0 0 2 2 1 0 AAA lid domain IstB_IS21 PF01695.17 CCF51419.1 - 0.061 13.1 0.5 1.8 8.3 0.5 2.3 1 1 0 1 1 1 0 IstB-like ATP binding protein AAA_7 PF12775.7 CCF51419.1 - 0.071 12.6 0.0 0.14 11.6 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region Cas_St_Csn2 PF16813.5 CCF51419.1 - 0.12 11.5 0.0 0.19 10.8 0.0 1.2 1 0 0 1 1 1 0 CRISPR-associated protein Csn2 subfamily St SMBP PF16785.5 CCF51419.1 - 0.37 11.0 5.7 0.84 9.9 4.3 2.3 2 0 0 2 2 2 0 Small metal-binding protein WD40 PF00400.32 CCF51421.1 - 8.4e-31 105.6 14.6 7.9e-06 26.5 0.3 7.4 7 0 0 7 7 7 6 WD domain, G-beta repeat Nup160 PF11715.8 CCF51421.1 - 2.5e-09 36.4 0.2 0.00027 19.7 0.0 4.2 4 1 1 5 5 5 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 CCF51421.1 - 5e-05 23.5 0.0 4.5 7.6 0.0 4.4 3 2 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Chs7 PF12271.8 CCF51422.1 - 1.3e-113 379.1 18.3 1.5e-113 378.9 18.3 1.0 1 0 0 1 1 1 1 Chitin synthase export chaperone Herpes_LMP2 PF07415.11 CCF51422.1 - 0.22 10.3 15.2 0.29 9.9 15.2 1.1 1 0 0 1 1 1 0 Gammaherpesvirus latent membrane protein (LMP2) protein Asn_synthase PF00733.21 CCF51423.1 - 2.4e-19 70.2 0.1 2.1e-08 34.2 0.0 3.1 2 1 1 3 3 3 3 Asparagine synthase GATase_7 PF13537.6 CCF51423.1 - 4.9e-10 39.4 0.0 1e-09 38.4 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.6 CCF51423.1 - 3.8e-08 33.6 0.0 7.9e-08 32.6 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain Rho_N PF07498.12 CCF51423.1 - 0.12 12.3 0.4 0.31 11.0 0.4 1.6 1 0 0 1 1 1 0 Rho termination factor, N-terminal domain RabGAP-TBC PF00566.18 CCF51424.1 - 1.1e-59 201.7 0.5 1.9e-59 201.0 0.5 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Cnn_1N PF07989.11 CCF51424.1 - 4.3 7.6 11.1 0.45 10.7 1.4 3.3 3 0 0 3 3 3 0 Centrosomin N-terminal motif 1 DNA_topoisoIV PF00521.20 CCF51425.1 - 4.7e-130 434.3 0.1 1e-129 433.2 0.0 1.6 2 0 0 2 2 2 1 DNA gyrase/topoisomerase IV, subunit A TOPRIM_C PF16898.5 CCF51425.1 - 8.5e-54 181.3 1.1 2.9e-53 179.5 1.1 2.0 1 0 0 1 1 1 1 C-terminal associated domain of TOPRIM DNA_gyraseB PF00204.25 CCF51425.1 - 9.8e-29 100.0 1.0 2.1e-28 99.0 1.0 1.6 1 0 0 1 1 1 1 DNA gyrase B HATPase_c PF02518.26 CCF51425.1 - 3.2e-15 56.6 0.0 1e-14 55.0 0.0 1.9 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Toprim PF01751.22 CCF51425.1 - 6e-09 36.1 0.0 2.3e-08 34.2 0.0 2.1 1 0 0 1 1 1 1 Toprim domain PP1_bind PF15276.6 CCF51425.1 - 0.29 11.4 1.7 0.58 10.5 0.2 2.3 2 0 0 2 2 2 0 Protein phosphatase 1 binding FLILHELTA PF10306.9 CCF51426.1 - 1.5e-17 63.8 0.0 3.7e-17 62.5 0.0 1.7 1 0 0 1 1 1 1 Hypothetical protein FLILHELTA tRNA-synt_2b PF00587.25 CCF51426.1 - 8e-17 61.8 0.0 6.8e-16 58.8 0.0 2.3 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) DUF1279 PF06916.13 CCF51426.1 - 0.056 14.0 0.1 0.21 12.1 0.1 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1279) Seryl_tRNA_N PF02403.22 CCF51426.1 - 0.42 10.9 18.2 0.25 11.6 3.4 2.6 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Phage_lysis PF03245.13 CCF51426.1 - 0.5 10.5 14.3 0.019 15.1 8.0 1.8 2 0 0 2 2 2 0 Bacteriophage Rz lysis protein GTP-bdg_M PF16360.5 CCF51426.1 - 1.4 9.5 9.7 7.8 7.2 9.7 2.3 1 1 0 1 1 1 0 GTP-binding GTPase Middle Region Alpha_GJ PF03229.13 CCF51426.1 - 1.5 9.4 4.9 2.1 8.9 0.8 2.6 2 0 0 2 2 2 0 Alphavirus glycoprotein J EMP24_GP25L PF01105.24 CCF51426.1 - 1.7 8.5 5.3 3.9 7.4 5.3 1.5 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD Nmad5 PF18757.1 CCF51426.1 - 9.9 6.3 10.8 19 5.4 10.8 1.4 1 0 0 1 1 1 0 Nucleotide modification associated domain 5 Band_7 PF01145.25 CCF51427.1 - 1.7e-23 83.6 6.5 3.7e-23 82.4 6.4 1.6 1 1 0 1 1 1 1 SPFH domain / Band 7 family YdfA_immunity PF12127.8 CCF51427.1 - 0.00074 18.7 3.4 0.00093 18.4 3.4 1.1 1 0 0 1 1 1 1 SigmaW regulon antibacterial AAA_lid_4 PF17864.1 CCF51427.1 - 0.025 14.3 0.5 0.025 14.3 0.5 2.7 1 1 2 3 3 3 0 RuvB AAA lid domain PNP_UDP_1 PF01048.20 CCF51428.1 - 7.9e-27 94.0 0.0 1.1e-26 93.6 0.0 1.1 1 0 0 1 1 1 1 Phosphorylase superfamily SAC3_GANP PF03399.16 CCF51430.1 - 1.2e-99 333.4 0.0 2e-99 332.7 0.0 1.4 1 0 0 1 1 1 1 SAC3/GANP family CSN8_PSD8_EIF3K PF10075.9 CCF51430.1 - 0.0016 18.4 0.1 0.031 14.3 0.0 2.4 2 0 0 2 2 2 1 CSN8/PSMD8/EIF3K family MFS_1 PF07690.16 CCF51431.1 - 1e-29 103.6 34.0 1.1e-21 77.2 18.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily CDP-OH_P_tran_2 PF08009.11 CCF51431.1 - 0.077 12.9 6.1 0.17 11.8 0.6 3.5 2 0 0 2 2 2 0 CDP-alcohol phosphatidyltransferase 2 FAM167 PF11652.8 CCF51432.1 - 0.03 14.8 1.9 0.12 12.9 1.9 2.0 1 0 0 1 1 1 0 FAM167 Rota_NS26 PF01525.16 CCF51432.1 - 0.12 12.3 2.7 0.14 12.2 0.6 2.1 2 0 0 2 2 2 0 Rotavirus NS26 Rep_fac-A_3 PF08661.11 CCF51432.1 - 0.28 11.6 1.4 5.4 7.4 0.1 2.8 2 1 0 2 2 2 0 Replication factor A protein 3 SPATA9 PF15824.5 CCF51432.1 - 0.4 9.9 3.6 0.51 9.6 0.7 2.1 2 0 0 2 2 2 0 Spermatogenesis-associated protein 9 GCN5L1 PF06320.13 CCF51432.1 - 5.9 7.1 12.2 0.6 10.3 1.0 3.3 3 0 0 3 3 3 0 GCN5-like protein 1 (GCN5L1) bZIP_1 PF00170.21 CCF51433.1 - 3.1e-10 40.0 12.4 6.5e-10 39.0 12.4 1.6 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 CCF51433.1 - 3.8e-07 30.1 10.0 3.8e-07 30.1 8.3 2.0 1 1 1 2 2 2 1 Basic region leucine zipper Prp31_C PF09785.9 CCF51433.1 - 0.019 15.9 0.6 0.055 14.4 0.2 2.1 2 0 0 2 2 2 0 Prp31 C terminal domain HAUS4 PF14735.6 CCF51433.1 - 0.077 12.7 4.7 0.14 11.8 4.7 1.3 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 4 Spt5_N PF11942.8 CCF51433.1 - 0.1 13.6 9.3 0.26 12.3 9.3 1.7 1 0 0 1 1 1 0 Spt5 transcription elongation factor, acidic N-terminal PNMA PF14893.6 CCF51433.1 - 0.15 11.4 2.8 0.16 11.4 1.3 1.6 2 0 0 2 2 2 0 PNMA FAM176 PF14851.6 CCF51433.1 - 2.9 7.5 6.5 7.2 6.3 6.5 1.6 1 0 0 1 1 1 0 FAM176 family CDC45 PF02724.14 CCF51433.1 - 3 6.0 10.9 5.1 5.3 10.9 1.3 1 0 0 1 1 1 0 CDC45-like protein GREB1 PF15782.5 CCF51433.1 - 10 3.1 13.0 17 2.4 13.0 1.3 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Ribosomal_S8e PF01201.22 CCF51436.1 - 1.2e-55 187.4 1.4 1.4e-55 187.2 1.4 1.1 1 0 0 1 1 1 1 Ribosomal protein S8e tRNA-synt_1 PF00133.22 CCF51437.1 - 1.5e-220 733.5 0.0 1.5e-219 730.2 0.0 2.0 1 1 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 CCF51437.1 - 1.6e-38 132.0 0.3 3.2e-38 131.1 0.3 1.5 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 CCF51437.1 - 4.6e-14 52.0 0.1 1.7e-06 27.1 0.0 4.4 4 1 0 4 4 4 3 tRNA synthetases class I (M) tRNA-synt_1_2 PF13603.6 CCF51437.1 - 5.2e-12 45.6 0.1 2.3e-07 30.5 0.1 2.6 1 1 1 2 2 2 2 Leucyl-tRNA synthetase, Domain 2 Val_tRNA-synt_C PF10458.9 CCF51437.1 - 0.0042 17.3 3.4 0.027 14.8 3.4 2.5 1 0 0 1 1 1 1 Valyl tRNA synthetase tRNA binding arm tRNA-synt_1e PF01406.19 CCF51437.1 - 0.051 12.9 0.0 1 8.6 0.0 2.4 2 0 0 2 2 2 0 tRNA synthetases class I (C) catalytic domain Methyltransf_23 PF13489.6 CCF51438.1 - 4.9e-09 36.2 0.0 9.3e-09 35.3 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF51438.1 - 2.7e-05 24.8 0.0 6e-05 23.7 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF51438.1 - 0.0003 21.4 0.0 0.00052 20.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF51438.1 - 0.00046 20.0 0.0 0.0013 18.5 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain DUF938 PF06080.12 CCF51438.1 - 0.00049 19.9 0.0 0.00074 19.3 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF938) Methyltransf_25 PF13649.6 CCF51438.1 - 0.082 13.6 0.0 0.17 12.6 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_9 PF08003.11 CCF51438.1 - 0.2 10.6 0.0 0.27 10.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) Fungal_trans PF04082.18 CCF51439.1 - 2.6e-12 46.3 0.0 5.8e-12 45.2 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF51439.1 - 0.00014 21.9 14.8 0.00026 21.1 14.8 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain UPF0253 PF06786.12 CCF51439.1 - 2.6 8.4 5.5 2.7 8.3 1.7 2.7 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0253) Aminotran_1_2 PF00155.21 CCF51440.1 - 5.2e-42 144.3 0.0 8.3e-42 143.6 0.0 1.3 1 1 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 CCF51440.1 - 0.0004 19.0 0.0 0.00077 18.1 0.0 1.4 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 CCF51440.1 - 0.031 13.6 0.0 0.052 12.9 0.0 1.2 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family Pectinesterase PF01095.19 CCF51441.1 - 5.5e-29 100.8 0.2 7.3e-25 87.3 0.2 2.1 2 0 0 2 2 2 2 Pectinesterase NAD_binding_10 PF13460.6 CCF51442.1 - 3.1e-31 108.7 0.0 4.3e-31 108.2 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 CCF51442.1 - 3.4e-05 23.4 0.0 4.6e-05 23.0 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family CYLD_phos_site PF16607.5 CCF51442.1 - 0.00084 19.2 1.6 0.21 11.4 0.6 2.2 1 1 1 2 2 2 2 Phosphorylation region of CYLD, unstructured NmrA PF05368.13 CCF51442.1 - 0.0016 18.0 0.0 0.0033 17.0 0.0 1.6 2 0 0 2 2 2 1 NmrA-like family NAD_binding_4 PF07993.12 CCF51442.1 - 0.21 10.7 0.0 0.27 10.4 0.0 1.2 1 0 0 1 1 1 0 Male sterility protein F-box-like PF12937.7 CCF51443.1 - 5e-13 48.7 0.2 1e-12 47.7 0.2 1.6 1 0 0 1 1 1 1 F-box-like WD40 PF00400.32 CCF51443.1 - 1.3e-10 41.6 0.8 0.00031 21.5 0.0 3.9 3 0 0 3 3 3 2 WD domain, G-beta repeat F-box PF00646.33 CCF51443.1 - 4.6e-10 39.1 0.3 1.2e-09 37.8 0.3 1.7 1 0 0 1 1 1 1 F-box domain HAD_2 PF13419.6 CCF51443.1 - 2.4e-05 24.5 0.0 3.8e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Nup160 PF11715.8 CCF51443.1 - 0.0075 15.0 0.0 0.12 11.0 0.0 2.6 3 0 0 3 3 3 1 Nucleoporin Nup120/160 PQQ_3 PF13570.6 CCF51443.1 - 0.074 13.6 0.8 15 6.2 0.2 4.0 4 0 0 4 4 4 0 PQQ-like domain Hydrolase_like PF13242.6 CCF51443.1 - 0.11 12.6 0.0 0.34 11.0 0.0 1.8 1 0 0 1 1 1 0 HAD-hyrolase-like Red1 PF07964.11 CCF51443.1 - 5 5.2 4.7 7.1 4.7 4.7 1.1 1 0 0 1 1 1 0 Rec10 / Red1 TB2_DP1_HVA22 PF03134.19 CCF51444.1 - 6.1e-29 99.8 7.3 6.1e-29 99.8 7.3 1.9 2 0 0 2 2 2 1 TB2/DP1, HVA22 family DUF3488 PF11992.8 CCF51444.1 - 0.0015 17.6 0.9 0.0018 17.3 0.9 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3488) CENP-I PF07778.11 CCF51445.1 - 3.3e-08 32.7 0.4 9.2e-08 31.2 0.4 1.7 1 0 0 1 1 1 1 Mis6 AA_permease_2 PF13520.6 CCF51447.1 - 1.3e-54 185.7 57.9 1.6e-54 185.4 57.9 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 CCF51447.1 - 5e-19 68.3 50.7 6.9e-19 67.8 50.7 1.1 1 0 0 1 1 1 1 Amino acid permease Aldedh PF00171.22 CCF51448.1 - 3.8e-176 586.1 0.2 4.4e-176 585.9 0.2 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Cu_amine_oxid PF01179.20 CCF51449.1 - 2.9e-152 507.3 0.3 3.5e-152 507.1 0.3 1.1 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain Cu_amine_oxidN3 PF02728.16 CCF51449.1 - 3.6e-12 46.6 0.0 6.9e-12 45.7 0.0 1.5 1 0 0 1 1 1 1 Copper amine oxidase, N3 domain Cu_amine_oxidN2 PF02727.16 CCF51449.1 - 0.0001 22.4 0.0 0.00027 21.1 0.0 1.7 1 0 0 1 1 1 1 Copper amine oxidase, N2 domain Zn_clus PF00172.18 CCF51450.1 - 0.00027 21.0 10.1 0.00042 20.4 10.1 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain QCR10 PF09796.9 CCF51451.1 - 3e-23 81.6 0.8 3.5e-23 81.4 0.8 1.1 1 0 0 1 1 1 1 Ubiquinol-cytochrome-c reductase complex subunit (QCR10) UCR_6-4kD PF08997.10 CCF51451.1 - 0.11 12.5 0.3 0.16 11.9 0.3 1.3 1 0 0 1 1 1 0 Ubiquinol-cytochrome C reductase complex, 6.4kD protein Gln-synt_C PF00120.24 CCF51452.1 - 8e-17 61.3 0.0 2e-15 56.6 0.0 2.1 1 1 0 1 1 1 1 Glutamine synthetase, catalytic domain Gln-synt_N PF03951.19 CCF51452.1 - 5.3e-12 45.3 0.0 9.3e-12 44.5 0.0 1.3 1 0 0 1 1 1 1 Glutamine synthetase, beta-Grasp domain DUF676 PF05057.14 CCF51453.1 - 5.9e-06 25.9 0.0 1.2e-05 25.0 0.0 1.4 1 1 0 1 1 1 1 Putative serine esterase (DUF676) PGAP1 PF07819.13 CCF51453.1 - 0.15 11.8 0.0 0.32 10.7 0.0 1.5 1 0 0 1 1 1 0 PGAP1-like protein LCAT PF02450.15 CCF51453.1 - 0.17 11.1 0.0 0.26 10.4 0.0 1.2 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase Ribosomal_L3 PF00297.22 CCF51454.1 - 9.7e-20 70.9 3.3 4.9e-17 62.0 2.7 2.3 1 1 1 2 2 2 2 Ribosomal protein L3 RVT_2 PF07727.14 CCF51455.1 - 9.1e-09 35.3 0.2 1.2e-08 34.9 0.2 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) CclA_1 PF16942.5 CCF51456.1 - 0.28 11.4 1.4 6.9 7.0 0.2 3.0 3 0 0 3 3 3 0 Putative cyclic bacteriocin rve PF00665.26 CCF51457.1 - 4.8e-07 30.0 0.0 1.2e-06 28.7 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain gag_pre-integrs PF13976.6 CCF51457.1 - 2.3e-06 27.4 0.3 5.3e-06 26.2 0.3 1.6 1 0 0 1 1 1 1 GAG-pre-integrase domain Pam16 PF03656.13 CCF51458.1 - 6.2e-19 68.3 0.8 5.7e-09 36.1 0.0 2.2 2 0 0 2 2 2 2 Pam16 tRNA-synt_1g PF09334.11 CCF51459.1 - 8.6e-150 498.8 0.0 1.3e-149 498.2 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 CCF51459.1 - 3.6e-07 28.8 0.3 0.00027 19.3 0.0 3.6 2 2 1 3 3 3 2 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 CCF51459.1 - 0.023 14.7 0.1 0.055 13.4 0.1 1.7 1 0 0 1 1 1 0 Anticodon-binding domain of tRNA Nse4-Nse3_bdg PF15412.6 CCF51459.1 - 0.095 12.8 0.1 40 4.4 0.0 3.2 3 0 0 3 3 3 0 Binding domain of Nse4/EID3 to Nse3-MAGE HypA PF01155.19 CCF51459.1 - 0.27 11.3 3.7 8.6 6.4 0.2 2.7 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DZR PF12773.7 CCF51459.1 - 1.1 9.3 8.8 0.91 9.6 5.3 2.2 1 1 1 2 2 2 0 Double zinc ribbon DUF16 PF01519.16 CCF51459.1 - 2.1 8.9 7.5 4.6 7.8 7.5 1.6 1 0 0 1 1 1 0 Protein of unknown function DUF16 zinc-ribbons_6 PF07191.12 CCF51459.1 - 3.2 7.8 6.3 6.4 6.8 3.9 2.0 1 1 2 3 3 3 0 zinc-ribbons Putative_PNPOx PF01243.20 CCF51460.1 - 0.089 13.0 0.0 0.2 11.8 0.0 1.6 1 0 0 1 1 1 0 Pyridoxamine 5'-phosphate oxidase F-box-like PF12937.7 CCF51460.1 - 0.13 12.1 0.1 0.24 11.3 0.1 1.5 1 0 0 1 1 1 0 F-box-like NP1-WLL PF11733.8 CCF51460.1 - 0.16 11.7 1.2 0.4 10.4 1.2 1.6 1 0 0 1 1 1 0 Non-capsid protein NP1 Ribosomal_L14 PF00238.19 CCF51461.1 - 4.2e-36 123.7 0.1 4.9e-36 123.5 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e F-box-like PF12937.7 CCF51462.1 - 0.0013 18.6 0.4 0.0041 17.0 0.4 1.9 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 CCF51462.1 - 0.01 15.7 0.1 0.038 13.9 0.1 1.9 1 1 0 1 1 1 0 F-box domain RT_RNaseH PF17917.1 CCF51464.1 - 6.6e-38 129.2 0.0 1.4e-37 128.1 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 CCF51464.1 - 3.4e-35 120.1 0.1 7.6e-35 119.0 0.1 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 CCF51464.1 - 5.5e-29 101.3 0.1 2.7e-28 99.0 0.0 2.2 3 0 0 3 3 3 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 CCF51464.1 - 5.3e-16 58.5 0.0 1.1e-15 57.4 0.0 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 CCF51464.1 - 5.4e-14 52.4 0.0 3.1e-13 49.9 0.0 2.4 2 0 0 2 2 2 1 Integrase core domain Chromo PF00385.24 CCF51464.1 - 3.1e-11 43.0 0.0 6.3e-11 42.0 0.0 1.6 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Retrotrans_gag PF03732.17 CCF51464.1 - 3.5e-10 40.0 0.4 2.6e-09 37.2 0.1 2.6 2 0 0 2 2 2 1 Retrotransposon gag protein DUF4939 PF16297.5 CCF51464.1 - 5.1e-09 36.0 0.0 1.2e-08 34.9 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4939) zf-H2C2 PF09337.10 CCF51464.1 - 3.5e-05 23.9 0.0 9.4e-05 22.6 0.0 1.8 1 0 0 1 1 1 1 H2C2 zinc finger RVP_2 PF08284.11 CCF51464.1 - 0.00017 21.4 0.0 0.00034 20.4 0.0 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease_2 PF13650.6 CCF51464.1 - 0.00077 20.1 0.0 0.0019 18.8 0.0 1.6 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 CCF51464.1 - 0.0048 17.4 0.1 0.022 15.3 0.0 2.1 2 0 0 2 2 2 1 gag-polyprotein putative aspartyl protease zf-C2H2_aberr PF17017.5 CCF51467.1 - 3.3e-06 27.3 2.5 0.044 13.9 0.1 2.3 2 0 0 2 2 2 2 Aberrant zinc-finger zf-C2H2 PF00096.26 CCF51467.1 - 0.018 15.5 10.6 0.12 12.9 0.6 3.4 3 0 0 3 3 3 0 Zinc finger, C2H2 type DUF3109 PF11307.8 CCF51467.1 - 0.12 12.2 0.1 0.26 11.1 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3109) zf-C2H2_4 PF13894.6 CCF51467.1 - 1.4 10.0 13.9 2 9.5 0.2 3.5 3 0 0 3 3 3 0 C2H2-type zinc finger OTCace PF00185.24 CCF51468.1 - 3.5e-45 153.9 0.0 5.2e-45 153.3 0.0 1.3 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain OTCace_N PF02729.21 CCF51468.1 - 1.4e-44 151.7 0.1 2.2e-44 151.0 0.1 1.3 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain Aminotran_1_2 PF00155.21 CCF51469.1 - 2.2e-18 66.6 0.0 2.7e-18 66.3 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_MocR PF12897.7 CCF51469.1 - 0.00016 20.6 0.0 0.00028 19.8 0.0 1.4 1 0 0 1 1 1 1 Alanine-glyoxylate amino-transferase Aminotran_3 PF00202.21 CCF51469.1 - 0.071 11.7 0.0 0.098 11.3 0.0 1.2 1 0 0 1 1 1 0 Aminotransferase class-III BAR_2 PF10455.9 CCF51470.1 - 1.4e-46 158.9 0.3 2.9e-46 157.9 0.3 1.4 1 1 0 1 1 1 1 Bin/amphiphysin/Rvs domain for vesicular trafficking BAR PF03114.18 CCF51470.1 - 1.2e-21 77.5 5.2 6.3e-17 62.0 2.6 2.1 2 0 0 2 2 2 2 BAR domain BAR_3 PF16746.5 CCF51470.1 - 0.0058 16.4 1.5 0.019 14.7 0.1 2.1 2 1 0 2 2 2 1 BAR domain of APPL family DUF4615 PF15393.6 CCF51470.1 - 0.018 15.6 0.2 6.5 7.3 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4615) Phasin PF05597.11 CCF51470.1 - 0.02 14.9 3.5 0.13 12.3 0.0 3.0 2 1 0 2 2 2 0 Poly(hydroxyalcanoate) granule associated protein (phasin) GIDA_assoc PF13932.6 CCF51470.1 - 0.046 13.9 1.4 0.38 10.9 0.4 2.1 2 0 0 2 2 2 0 GidA associated domain Uds1 PF15456.6 CCF51470.1 - 0.097 12.8 10.0 0.42 10.8 0.1 2.9 2 1 0 2 2 2 0 Up-regulated During Septation zf-C4H2 PF10146.9 CCF51470.1 - 0.1 12.9 0.1 0.1 12.9 0.1 2.2 2 0 0 2 2 2 0 Zinc finger-containing protein bZIP_1 PF00170.21 CCF51470.1 - 0.13 12.4 0.7 1.1 9.4 0.0 2.5 2 0 0 2 2 2 0 bZIP transcription factor I_LWEQ PF01608.17 CCF51470.1 - 0.14 12.4 6.9 0.17 12.1 3.9 2.4 2 0 0 2 2 2 0 I/LWEQ domain DUF16 PF01519.16 CCF51470.1 - 0.34 11.4 4.1 0.37 11.3 0.8 2.4 2 1 0 2 2 2 0 Protein of unknown function DUF16 DUF148 PF02520.17 CCF51470.1 - 0.39 10.8 8.2 5.1 7.3 4.0 3.2 2 2 0 2 2 2 0 Domain of unknown function DUF148 Sec8_exocyst PF04048.14 CCF51470.1 - 0.65 9.9 5.1 0.63 9.9 1.2 2.8 2 1 1 3 3 3 0 Sec8 exocyst complex component specific domain Fib_alpha PF08702.10 CCF51470.1 - 1.1 9.4 3.6 6.9 6.9 0.5 2.5 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family Spectrin PF00435.21 CCF51470.1 - 1.8 9.1 8.1 7.7 7.1 0.2 3.0 2 2 0 2 2 2 0 Spectrin repeat TMF_DNA_bd PF12329.8 CCF51470.1 - 1.8 8.6 10.7 2.7 8.1 0.1 3.7 3 2 1 4 4 4 0 TATA element modulatory factor 1 DNA binding PCRF PF03462.18 CCF51470.1 - 1.9 8.3 7.4 6.2 6.6 0.0 2.5 2 1 0 2 2 2 0 PCRF domain ATG16 PF08614.11 CCF51470.1 - 3 8.0 11.7 0.69 10.1 5.2 2.4 2 1 0 2 2 2 0 Autophagy protein 16 (ATG16) HSCB_C PF07743.13 CCF51470.1 - 3 8.4 11.1 13 6.3 7.4 3.3 2 1 0 2 2 2 0 HSCB C-terminal oligomerisation domain HTH_28 PF13518.6 CCF51471.1 - 0.19 11.9 3.3 0.58 10.3 3.3 1.8 1 0 0 1 1 1 0 Helix-turn-helix domain DUF4451 PF14616.6 CCF51472.1 - 9.3e-32 109.8 0.5 1.7e-31 109.0 0.5 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4451) Hydin_ADK PF17213.3 CCF51472.1 - 2.3 8.5 8.5 3.7 7.8 8.5 1.3 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain MDFI PF15316.6 CCF51472.1 - 2.7 8.0 4.1 5 7.2 4.1 1.5 1 0 0 1 1 1 0 MyoD family inhibitor API5 PF05918.11 CCF51472.1 - 4 6.1 7.7 5.9 5.6 7.7 1.2 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) Presenilin PF01080.17 CCF51472.1 - 6.2 5.5 6.1 9.8 4.8 6.1 1.2 1 0 0 1 1 1 0 Presenilin CMS1 PF14617.6 CCF51473.1 - 3.8e-51 173.9 2.5 9.2e-26 90.7 0.0 2.1 2 0 0 2 2 2 2 U3-containing 90S pre-ribosomal complex subunit DUF1180 PF06679.12 CCF51473.1 - 5 7.5 9.8 1.7 9.0 4.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1180) ING PF12998.7 CCF51474.1 - 5.8e-11 42.9 1.0 8.1e-11 42.4 1.0 1.2 1 0 0 1 1 1 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.29 CCF51474.1 - 2.6e-06 27.2 7.0 4.1e-06 26.6 7.0 1.3 1 0 0 1 1 1 1 PHD-finger CEP63 PF17045.5 CCF51474.1 - 0.0061 16.5 0.5 0.0088 16.0 0.5 1.1 1 0 0 1 1 1 1 Centrosomal protein of 63 kDa Tmemb_cc2 PF10267.9 CCF51474.1 - 0.028 13.6 0.4 0.041 13.0 0.4 1.2 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein PHD_2 PF13831.6 CCF51474.1 - 0.037 13.6 2.0 0.069 12.7 2.0 1.4 1 0 0 1 1 1 0 PHD-finger Baculo_PEP_C PF04513.12 CCF51474.1 - 0.17 11.9 0.1 3.5 7.7 0.1 2.1 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus APG6_N PF17675.1 CCF51474.1 - 1.6 9.3 4.1 15 6.2 0.6 2.3 2 0 0 2 2 2 0 Apg6 coiled-coil region CPSase_L_D2 PF02786.17 CCF51475.1 - 4.8e-113 375.9 0.1 1.5e-82 276.2 0.0 2.3 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain GATase PF00117.28 CCF51475.1 - 2.9e-48 164.2 0.0 6.1e-47 159.9 0.0 2.4 2 0 0 2 2 2 1 Glutamine amidotransferase class-I CPSase_sm_chain PF00988.22 CCF51475.1 - 1e-47 161.1 0.0 2.2e-47 160.1 0.0 1.6 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain OTCace_N PF02729.21 CCF51475.1 - 4.8e-45 153.2 0.0 1.2e-44 151.9 0.0 1.7 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain CPSase_L_D3 PF02787.19 CCF51475.1 - 1.4e-41 141.6 0.2 3e-41 140.6 0.2 1.6 1 0 0 1 1 1 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain OTCace PF00185.24 CCF51475.1 - 6.1e-29 101.1 0.0 1.6e-28 99.8 0.0 1.8 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain ATP-grasp PF02222.22 CCF51475.1 - 6.9e-18 64.8 0.0 9.4e-09 35.1 0.0 2.4 2 0 0 2 2 2 2 ATP-grasp domain Dala_Dala_lig_C PF07478.13 CCF51475.1 - 7e-18 64.9 0.1 2.7e-08 33.6 0.0 2.6 2 0 0 2 2 2 2 D-ala D-ala ligase C-terminus ATPgrasp_Ter PF15632.6 CCF51475.1 - 1.8e-10 40.7 0.1 6.3e-05 22.7 0.0 3.0 2 1 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon MGS PF02142.22 CCF51475.1 - 4.7e-10 39.5 0.0 1.4e-09 38.0 0.0 1.9 1 0 0 1 1 1 1 MGS-like domain Peptidase_C26 PF07722.13 CCF51475.1 - 2.8e-06 27.2 0.1 0.00038 20.3 0.1 2.7 1 1 0 1 1 1 1 Peptidase C26 ATP-grasp_3 PF02655.14 CCF51475.1 - 6.7e-05 23.0 0.1 0.13 12.3 0.0 2.7 2 0 0 2 2 2 2 ATP-grasp domain GARS_A PF01071.19 CCF51475.1 - 0.00077 19.3 0.0 0.051 13.3 0.0 2.8 2 1 0 2 2 2 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain DUF1247 PF06851.11 CCF51475.1 - 0.12 12.3 0.0 0.27 11.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1247) TrkA_N PF02254.18 CCF51475.1 - 0.14 12.4 0.1 6.7 7.0 0.0 3.2 3 0 0 3 3 3 0 TrkA-N domain CRAL_TRIO PF00650.20 CCF51476.1 - 1.4e-25 89.8 0.0 2.1e-25 89.3 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 CCF51476.1 - 1.1e-06 28.6 0.2 4.3e-06 26.8 0.1 2.0 1 1 1 2 2 2 1 CRAL/TRIO, N-terminal domain PI31_Prot_C PF08577.11 CCF51478.1 - 0.061 14.5 2.2 0.7 11.1 2.2 3.0 1 0 0 1 1 1 0 PI31 proteasome regulator DUF2559 PF10832.8 CCF51478.1 - 0.094 12.8 0.3 0.22 11.6 0.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2559) Ses_B PF17046.5 CCF51478.1 - 0.35 10.9 8.4 1.4 8.9 8.4 2.1 1 0 0 1 1 1 0 SesB domain on fungal death-pathway protein ADH_N_2 PF16884.5 CCF51479.1 - 6.7e-30 103.2 0.2 2.6e-29 101.3 0.1 2.0 2 0 0 2 2 2 1 N-terminal domain of oxidoreductase ADH_zinc_N PF00107.26 CCF51479.1 - 6.2e-24 84.4 0.1 1.5e-23 83.2 0.0 1.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CCF51479.1 - 5.3e-09 37.2 0.0 4.5e-08 34.2 0.0 2.5 2 1 0 2 2 2 1 Zinc-binding dehydrogenase adh_short PF00106.25 CCF51479.1 - 9.7e-06 25.2 0.1 1.5e-05 24.5 0.1 1.3 1 0 0 1 1 1 1 short chain dehydrogenase Epimerase PF01370.21 CCF51479.1 - 0.089 12.2 0.0 0.14 11.6 0.0 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family MIF4G PF02854.19 CCF51480.1 - 2.1e-49 168.1 0.0 7.8e-28 97.6 0.0 3.5 3 0 0 3 3 3 3 MIF4G domain Upf2 PF04050.14 CCF51480.1 - 1.7e-24 87.1 2.3 1.7e-24 87.1 2.3 4.0 3 1 0 3 3 3 1 Up-frameshift suppressor 2 PDEase_I_N PF08499.12 CCF51480.1 - 0.43 10.5 1.8 0.63 9.9 0.0 2.3 2 0 0 2 2 2 0 3'5'-cyclic nucleotide phosphodiesterase N-terminal AC_N PF16214.5 CCF51480.1 - 3.6 6.6 7.1 12 4.9 7.1 1.8 1 0 0 1 1 1 0 Adenylyl cyclase N-terminal extracellular and transmembrane region RNA_pol_A_bac PF01000.26 CCF51481.1 - 1.9e-27 95.9 0.0 6.1e-27 94.2 0.0 1.8 2 0 0 2 2 2 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 CCF51481.1 - 1.6e-17 62.7 0.0 2.3e-17 62.2 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain GMC_oxred_N PF00732.19 CCF51483.1 - 1.6e-55 188.6 1.4 2e-53 181.7 1.4 2.1 1 1 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 CCF51483.1 - 2.7e-27 96.1 0.0 5.3e-27 95.1 0.0 1.5 1 0 0 1 1 1 1 GMC oxidoreductase FAD_binding_2 PF00890.24 CCF51483.1 - 1.2e-09 37.8 0.7 0.0005 19.3 0.0 2.3 2 0 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.6 CCF51483.1 - 1.5e-05 25.1 1.0 9.3e-05 22.6 0.3 2.7 2 1 1 3 3 3 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CCF51483.1 - 4.9e-05 23.1 4.3 0.00081 19.1 4.3 2.1 1 1 0 1 1 1 1 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 CCF51483.1 - 8.1e-05 21.8 0.1 0.00012 21.3 0.1 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein Pyr_redox_2 PF07992.14 CCF51483.1 - 0.00019 20.8 0.1 0.0033 16.7 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CCF51483.1 - 0.0059 15.3 0.3 0.19 10.4 0.1 2.1 2 0 0 2 2 2 1 HI0933-like protein Thi4 PF01946.17 CCF51483.1 - 0.011 15.0 0.6 0.031 13.5 0.4 1.8 2 0 0 2 2 2 0 Thi4 family Pyr_redox_3 PF13738.6 CCF51483.1 - 0.013 14.8 0.0 0.11 11.8 0.0 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 CCF51483.1 - 0.057 12.5 0.2 5.7 5.9 0.0 2.1 2 0 0 2 2 2 0 Glucose inhibited division protein A FAD_binding_3 PF01494.19 CCF51483.1 - 0.065 12.5 0.0 0.11 11.8 0.0 1.3 1 0 0 1 1 1 0 FAD binding domain NAD_binding_9 PF13454.6 CCF51483.1 - 0.069 13.1 0.0 0.17 11.8 0.0 1.7 1 0 0 1 1 1 0 FAD-NAD(P)-binding HSP90 PF00183.18 CCF51484.1 - 0.96 8.3 5.2 1.7 7.4 5.2 1.3 1 0 0 1 1 1 0 Hsp90 protein BUD22 PF09073.10 CCF51484.1 - 0.97 8.7 31.3 1.1 8.5 31.3 1.0 1 0 0 1 1 1 0 BUD22 PPP4R2 PF09184.11 CCF51484.1 - 4.4 6.8 20.9 5.5 6.5 20.9 1.2 1 0 0 1 1 1 0 PPP4R2 SURF2 PF05477.11 CCF51484.1 - 5.4 6.6 16.3 6.8 6.3 16.3 1.2 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) DUF4385 PF14328.6 CCF51485.1 - 7.3e-65 217.5 0.2 1.1e-64 216.9 0.2 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4385) MFS_1 PF07690.16 CCF51486.1 - 3e-31 108.6 23.2 4.5e-31 108.0 23.2 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF51486.1 - 5.5e-12 45.3 0.6 5.5e-12 45.3 0.6 1.8 2 0 0 2 2 2 1 Sugar (and other) transporter MFS_4 PF06779.14 CCF51486.1 - 0.00019 20.9 4.1 0.0003 20.2 0.2 2.4 2 0 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB CN_hydrolase PF00795.22 CCF51487.1 - 7e-34 117.3 0.0 9.7e-34 116.9 0.0 1.2 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase NAD_synthase PF02540.17 CCF51487.1 - 6.3e-22 77.9 0.0 6.3e-19 68.0 0.0 2.2 1 1 0 1 1 1 1 NAD synthase Fungal_trans PF04082.18 CCF51489.1 - 1.9e-26 92.7 0.4 3.4e-26 91.9 0.0 1.5 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF51489.1 - 3.8e-07 30.1 8.5 7.9e-07 29.1 8.5 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Sec6 PF06046.13 CCF51490.1 - 5.2e-164 546.8 0.0 6.6e-164 546.4 0.0 1.1 1 0 0 1 1 1 1 Exocyst complex component Sec6 Vps53_N PF04100.12 CCF51490.1 - 0.051 12.5 2.2 0.72 8.7 0.5 2.5 3 0 0 3 3 3 0 Vps53-like, N-terminal NPV_P10 PF05531.12 CCF51490.1 - 0.1 13.1 0.9 1.1 9.8 0.0 2.9 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein PAS_9 PF13426.7 CCF51490.1 - 0.16 12.2 0.0 2.4 8.5 0.0 2.5 2 0 0 2 2 2 0 PAS domain APG6_N PF17675.1 CCF51491.1 - 0.0032 18.0 9.2 0.0056 17.2 9.2 1.5 1 0 0 1 1 1 1 Apg6 coiled-coil region BRE1 PF08647.11 CCF51491.1 - 0.028 14.5 4.7 0.048 13.7 4.7 1.3 1 0 0 1 1 1 0 BRE1 E3 ubiquitin ligase Jnk-SapK_ap_N PF09744.9 CCF51491.1 - 0.03 14.5 5.4 0.049 13.9 5.4 1.5 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 DUF724 PF05266.14 CCF51491.1 - 0.038 13.8 3.5 0.061 13.1 3.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF724) DUF1359 PF07097.11 CCF51491.1 - 0.039 14.2 0.0 0.13 12.6 0.0 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1359) Fungal_TACC PF12709.7 CCF51491.1 - 0.042 14.3 5.6 0.085 13.3 2.7 2.4 1 1 1 2 2 2 0 Fungal Transforming acidic coiled-coil (TACC) proteins FapA PF03961.13 CCF51491.1 - 0.053 12.1 2.4 0.068 11.8 2.4 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A Sec34 PF04136.15 CCF51491.1 - 0.081 12.8 4.4 0.15 11.9 4.4 1.5 1 1 0 1 1 1 0 Sec34-like family PI3K_P85_iSH2 PF16454.5 CCF51491.1 - 0.097 12.3 5.5 0.28 10.8 3.3 2.0 1 1 1 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain PRKG1_interact PF15898.5 CCF51491.1 - 6.2 7.8 9.6 12 6.8 1.6 2.5 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain CHCH PF06747.13 CCF51492.1 - 2.8e-06 27.3 2.3 5.5e-06 26.4 2.3 1.5 1 0 0 1 1 1 1 CHCH domain GCK PF07802.11 CCF51492.1 - 0.0044 17.4 1.8 0.011 16.2 1.8 1.7 1 0 0 1 1 1 1 GCK domain PAP2 PF01569.21 CCF51494.1 - 9.6e-21 74.0 3.4 2.5e-20 72.6 3.4 1.7 1 0 0 1 1 1 1 PAP2 superfamily WD40 PF00400.32 CCF51495.1 - 1.4e-57 190.3 26.1 3.4e-09 37.2 0.0 9.1 9 0 0 9 9 9 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF51495.1 - 1.6e-16 60.3 2.4 0.00044 20.5 0.0 5.3 3 2 2 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain NLE PF08154.12 CCF51495.1 - 5.4e-05 23.6 0.3 0.00014 22.3 0.3 1.7 1 1 0 1 1 1 1 NLE (NUC135) domain Ge1_WD40 PF16529.5 CCF51495.1 - 0.00011 21.2 0.0 0.23 10.4 0.0 3.9 4 2 1 5 5 5 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 CCF51495.1 - 0.00013 20.7 2.6 0.43 9.2 0.1 4.4 4 1 1 5 5 5 2 Nucleoporin Nup120/160 eIF2A PF08662.11 CCF51495.1 - 0.00032 20.6 0.0 0.0016 18.3 0.0 2.1 3 0 0 3 3 3 1 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 CCF51495.1 - 0.017 15.1 0.6 1.5 8.8 0.0 3.9 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat Proteasome_A_N PF10584.9 CCF51495.1 - 0.032 13.9 0.1 12 5.7 0.1 3.4 3 0 0 3 3 3 0 Proteasome subunit A N-terminal signature Nbas_N PF15492.6 CCF51495.1 - 0.1 11.9 0.2 3.3 7.0 0.0 2.8 2 1 1 3 3 3 0 Neuroblastoma-amplified sequence, N terminal Frtz PF11768.8 CCF51495.1 - 0.14 10.4 0.0 0.45 8.8 0.0 1.7 2 0 0 2 2 2 0 WD repeat-containing and planar cell polarity effector protein Fritz IKI3 PF04762.12 CCF51495.1 - 0.16 9.9 0.0 0.27 9.2 0.0 1.3 1 0 0 1 1 1 0 IKI3 family DNA_pol_phi PF04931.13 CCF51495.1 - 9.5 4.2 8.5 14 3.6 8.5 1.1 1 0 0 1 1 1 0 DNA polymerase phi SURF6 PF04935.12 CCF51496.1 - 2.8e-46 157.8 35.1 2.8e-46 157.8 35.1 3.0 2 1 1 3 3 3 1 Surfeit locus protein 6 RRP14 PF15459.6 CCF51496.1 - 4.1e-18 65.7 3.9 4.1e-18 65.7 3.9 6.1 5 1 0 5 5 5 1 60S ribosome biogenesis protein Rrp14 EPSP_synthase PF00275.20 CCF51497.1 - 9.9e-113 377.0 0.0 1.4e-112 376.5 0.0 1.2 1 0 0 1 1 1 1 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) DHQ_synthase PF01761.20 CCF51497.1 - 2.2e-97 325.3 0.0 7.6e-97 323.6 0.0 1.9 3 0 0 3 3 3 1 3-dehydroquinate synthase DHquinase_I PF01487.15 CCF51497.1 - 4.5e-53 180.8 0.0 9.6e-53 179.8 0.0 1.6 1 0 0 1 1 1 1 Type I 3-dehydroquinase Shikimate_dh_N PF08501.11 CCF51497.1 - 3.7e-27 94.4 0.0 1.1e-26 92.9 0.0 1.9 1 0 0 1 1 1 1 Shikimate dehydrogenase substrate binding domain SKI PF01202.22 CCF51497.1 - 1.4e-24 87.0 0.0 3.3e-24 85.8 0.0 1.6 1 0 0 1 1 1 1 Shikimate kinase SDH_C PF18317.1 CCF51497.1 - 1.4e-06 27.9 0.0 2.9e-06 27.0 0.0 1.5 1 0 0 1 1 1 1 Shikimate 5'-dehydrogenase C-terminal domain Shikimate_DH PF01488.20 CCF51497.1 - 1.8e-06 28.0 0.0 4.3e-06 26.8 0.0 1.6 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Fe-ADH_2 PF13685.6 CCF51497.1 - 8.7e-05 22.3 0.4 0.00026 20.8 0.4 1.8 1 1 0 1 1 1 1 Iron-containing alcohol dehydrogenase OCD_Mu_crystall PF02423.15 CCF51497.1 - 0.0022 17.0 0.2 0.018 14.0 0.1 2.1 2 0 0 2 2 2 1 Ornithine cyclodeaminase/mu-crystallin family Abhydrolase_9_N PF15420.6 CCF51498.1 - 3.6 7.6 12.3 3.1 7.8 8.2 2.4 2 1 0 2 2 2 0 Alpha/beta-hydrolase family N-terminus Glyco_hydro_65m PF03632.15 CCF51499.1 - 0.057 12.3 0.0 0.072 11.9 0.0 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 65 central catalytic domain Glyco_hydro_32N PF00251.20 CCF51500.1 - 4.2e-46 157.9 0.0 5.8e-46 157.5 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 32 N-terminal domain Glyco_hydro_32C PF08244.12 CCF51500.1 - 2.8e-19 69.6 0.0 3.9e-19 69.2 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 32 C terminal BNR PF02012.20 CCF51500.1 - 0.56 10.4 2.6 14 6.2 1.7 3.0 2 0 0 2 2 2 0 BNR/Asp-box repeat Pil1 PF13805.6 CCF51501.1 - 4.2e-17 62.5 1.4 8.6e-17 61.5 1.4 1.4 1 0 0 1 1 1 1 Eisosome component PIL1 Ras PF00071.22 CCF51502.1 - 1.9e-54 183.7 0.1 2.2e-54 183.4 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CCF51502.1 - 6.9e-31 107.0 0.0 8.9e-31 106.6 0.0 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CCF51502.1 - 3.3e-16 59.2 0.0 5e-16 58.7 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 CCF51502.1 - 2.1e-05 24.5 0.0 3e-05 24.1 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 CCF51502.1 - 0.0032 16.9 0.0 0.0041 16.5 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 CCF51502.1 - 0.0088 15.6 0.1 0.024 14.2 0.1 1.8 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 CCF51502.1 - 0.0088 15.5 0.0 0.012 15.1 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_24 PF13479.6 CCF51502.1 - 0.039 13.7 0.2 0.095 12.4 0.1 1.8 1 1 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 CCF51502.1 - 0.083 12.8 0.0 1.2 9.1 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase TniB PF05621.11 CCF51502.1 - 0.24 10.8 0.0 0.36 10.2 0.0 1.2 1 0 0 1 1 1 0 Bacterial TniB protein zf-CSL PF05207.13 CCF51503.1 - 2.9e-23 81.3 0.8 4e-23 80.9 0.8 1.2 1 0 0 1 1 1 1 CSL zinc finger Zn-ribbon_8 PF09723.10 CCF51503.1 - 0.00056 20.0 0.4 0.001 19.1 0.4 1.5 1 0 0 1 1 1 1 Zinc ribbon domain zf-RING_4 PF14570.6 CCF51503.1 - 0.00078 19.2 0.7 0.0012 18.5 0.7 1.3 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zinc_ribbon_4 PF13717.6 CCF51503.1 - 0.038 13.9 0.9 0.057 13.3 0.9 1.3 1 0 0 1 1 1 0 zinc-ribbon domain Septin PF00735.18 CCF51505.1 - 2.3e-112 374.9 0.1 3e-112 374.5 0.1 1.1 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 CCF51505.1 - 4e-09 36.6 0.1 1e-08 35.3 0.1 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CCF51505.1 - 8.7e-08 32.2 0.4 6.2e-07 29.5 0.2 2.3 2 0 0 2 2 2 1 RsgA GTPase GTP_EFTU PF00009.27 CCF51505.1 - 4e-07 29.8 2.0 3.1e-05 23.6 0.3 2.6 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain Roc PF08477.13 CCF51505.1 - 5e-05 23.5 0.2 0.0001 22.5 0.2 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 CCF51505.1 - 5.7e-05 22.8 0.4 0.00015 21.4 0.4 1.7 1 1 0 1 1 1 1 Ras family AAA_16 PF13191.6 CCF51505.1 - 0.00019 21.9 0.1 0.00084 19.8 0.0 2.1 3 0 0 3 3 3 1 AAA ATPase domain AIG1 PF04548.16 CCF51505.1 - 0.00048 19.5 0.1 0.0009 18.6 0.1 1.4 1 0 0 1 1 1 1 AIG1 family AAA_22 PF13401.6 CCF51505.1 - 0.00082 19.7 1.1 0.0017 18.7 0.1 2.1 2 1 0 2 2 2 1 AAA domain AAA_24 PF13479.6 CCF51505.1 - 0.0019 17.9 1.0 0.021 14.5 0.0 2.3 2 0 0 2 2 2 1 AAA domain ABC_tran PF00005.27 CCF51505.1 - 0.002 18.6 0.2 0.0063 17.0 0.0 1.9 2 0 0 2 2 2 1 ABC transporter PduV-EutP PF10662.9 CCF51505.1 - 0.0055 16.5 1.7 0.15 11.8 0.4 2.8 2 1 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation Gtr1_RagA PF04670.12 CCF51505.1 - 0.01 15.2 0.1 0.026 13.9 0.0 1.7 2 0 0 2 2 2 0 Gtr1/RagA G protein conserved region NACHT PF05729.12 CCF51505.1 - 0.018 15.0 0.0 0.033 14.1 0.0 1.4 1 0 0 1 1 1 0 NACHT domain GPW_gp25 PF04965.14 CCF51505.1 - 0.02 14.7 0.7 3 7.7 0.3 2.6 2 0 0 2 2 2 0 Gene 25-like lysozyme Mg_chelatase PF01078.21 CCF51505.1 - 0.023 14.1 0.0 0.043 13.2 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_7 PF12775.7 CCF51505.1 - 0.023 14.2 0.1 0.044 13.3 0.1 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region NB-ARC PF00931.22 CCF51505.1 - 0.026 13.7 0.0 0.045 12.9 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain FeoB_N PF02421.18 CCF51505.1 - 0.026 14.0 0.2 0.087 12.3 0.2 1.9 1 1 0 1 1 1 0 Ferrous iron transport protein B AAA_29 PF13555.6 CCF51505.1 - 0.026 14.2 0.1 0.05 13.3 0.1 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain ATP_bind_1 PF03029.17 CCF51505.1 - 0.038 13.8 0.6 2.6 7.8 0.1 2.5 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_23 PF13476.6 CCF51505.1 - 0.053 14.0 3.5 0.19 12.2 0.0 2.2 2 0 0 2 2 2 0 AAA domain Sigma54_activat PF00158.26 CCF51505.1 - 0.055 13.2 0.1 0.11 12.2 0.1 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain RNA_helicase PF00910.22 CCF51505.1 - 0.091 13.2 0.0 0.2 12.0 0.0 1.7 1 0 0 1 1 1 0 RNA helicase CLP1_P PF16575.5 CCF51505.1 - 0.097 12.5 0.2 3.2 7.5 0.0 2.3 1 1 1 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop Pox_A32 PF04665.12 CCF51505.1 - 0.11 11.9 0.1 0.21 11.0 0.1 1.4 1 0 0 1 1 1 0 Poxvirus A32 protein AAA_14 PF13173.6 CCF51505.1 - 0.13 12.3 0.4 0.26 11.3 0.0 1.8 2 0 0 2 2 2 0 AAA domain cobW PF02492.19 CCF51505.1 - 0.13 11.8 0.3 0.47 10.0 0.1 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA PF00004.29 CCF51505.1 - 0.16 12.4 1.5 0.53 10.7 0.2 2.4 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Dynamin_N PF00350.23 CCF51505.1 - 0.43 10.6 7.0 1.9 8.5 0.4 2.8 2 1 1 3 3 3 0 Dynamin family Cep57_CLD_2 PF14197.6 CCF51505.1 - 3.5 7.8 8.8 0.34 11.0 3.0 2.3 2 1 1 3 3 2 0 Centrosome localisation domain of PPC89 ENTH PF01417.20 CCF51506.1 - 5.3e-50 168.7 0.2 9.6e-50 167.8 0.2 1.5 1 0 0 1 1 1 1 ENTH domain UIM PF02809.20 CCF51506.1 - 8e-06 25.4 7.3 0.0039 17.0 1.2 3.3 2 0 0 2 2 2 2 Ubiquitin interaction motif ANTH PF07651.16 CCF51506.1 - 0.00029 19.9 0.6 0.00059 18.9 0.6 1.6 1 0 0 1 1 1 1 ANTH domain p450 PF00067.22 CCF51507.1 - 1.7e-29 102.9 0.0 3.1e-29 102.1 0.0 1.3 1 0 0 1 1 1 1 Cytochrome P450 Npa1 PF11707.8 CCF51508.1 - 6.6e-108 361.1 0.1 2.9e-107 358.9 0.0 2.3 2 0 0 2 2 2 1 Ribosome 60S biogenesis N-terminal NopRA1 PF16201.5 CCF51508.1 - 1.1e-53 181.8 0.0 7.4e-53 179.1 0.0 2.6 1 0 0 1 1 1 1 Nucleolar pre-ribosomal-associated protein 1 Metallophos PF00149.28 CCF51509.1 - 1.1e-12 48.9 0.0 4.8e-12 46.8 0.0 2.1 2 1 0 2 2 2 1 Calcineurin-like phosphoesterase GMC_oxred_N PF00732.19 CCF51510.1 - 7e-50 170.1 0.1 3.7e-48 164.4 0.1 2.1 1 1 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 CCF51510.1 - 6.6e-36 124.0 0.0 1.2e-35 123.2 0.0 1.4 1 0 0 1 1 1 1 GMC oxidoreductase FAD_binding_2 PF00890.24 CCF51510.1 - 0.00011 21.5 1.4 0.0012 18.1 1.4 2.0 1 1 0 1 1 1 1 FAD binding domain Thi4 PF01946.17 CCF51510.1 - 0.0019 17.5 0.3 0.0036 16.6 0.3 1.4 1 0 0 1 1 1 1 Thi4 family Lycopene_cycl PF05834.12 CCF51510.1 - 0.0019 17.3 0.1 0.0034 16.5 0.1 1.4 1 0 0 1 1 1 1 Lycopene cyclase protein DAO PF01266.24 CCF51510.1 - 0.0048 16.5 0.1 0.038 13.6 0.0 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CCF51510.1 - 0.0071 16.6 0.1 0.023 14.9 0.1 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 CCF51510.1 - 0.043 12.5 0.7 5.3 5.6 0.3 2.1 2 0 0 2 2 2 0 HI0933-like protein Pyr_redox_2 PF07992.14 CCF51510.1 - 0.067 12.4 0.0 0.36 10.0 0.0 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Bundlin PF05307.11 CCF51510.1 - 0.079 12.8 1.7 0.49 10.3 0.0 2.8 3 0 0 3 3 3 0 Bundlin CAF1A PF12253.8 CCF51510.1 - 1.3 9.3 9.7 13 6.0 4.7 3.1 3 0 0 3 3 3 0 Chromatin assembly factor 1 subunit A Fungal_trans PF04082.18 CCF51512.1 - 7.1e-30 103.9 0.0 1.2e-29 103.2 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF51512.1 - 5.1e-09 36.1 10.0 8.5e-09 35.4 10.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain TRAM_LAG1_CLN8 PF03798.16 CCF51514.1 - 1.5e-45 155.4 26.4 2e-45 155.0 22.6 2.5 3 0 0 3 3 3 1 TLC domain TRAM1 PF08390.11 CCF51514.1 - 2.8e-08 33.3 1.9 3.1e-08 33.1 0.0 2.2 2 1 0 2 2 2 1 TRAM1-like protein DUF1230 PF06799.11 CCF51514.1 - 0.19 11.8 6.3 0.093 12.8 2.1 2.2 1 1 1 2 2 2 0 Conserved in the green lineage and diatoms 27 OTOS PF15182.6 CCF51514.1 - 0.21 11.5 3.7 0.55 10.2 3.7 1.7 1 0 0 1 1 1 0 Otospiralin rve PF00665.26 CCF51517.1 - 5.8e-12 45.9 0.1 9.9e-12 45.1 0.1 1.4 1 0 0 1 1 1 1 Integrase core domain Chromo PF00385.24 CCF51517.1 - 3.2e-10 39.8 1.0 1.8e-09 37.4 0.1 2.3 2 0 0 2 2 2 1 Chromo (CHRromatin Organisation MOdifier) domain RVT_1 PF00078.27 CCF51518.1 - 7.9e-25 87.7 0.1 1.4e-24 86.8 0.1 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 CCF51518.1 - 8.4e-09 35.4 0.0 1.6e-08 34.5 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase gag-asp_proteas PF13975.6 CCF51518.1 - 0.0057 17.2 0.1 0.01 16.4 0.1 1.4 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease RVP_2 PF08284.11 CCF51518.1 - 0.0089 15.8 0.0 0.016 15.0 0.0 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease_2 PF13650.6 CCF51518.1 - 0.013 16.1 0.1 0.029 15.0 0.1 1.5 1 0 0 1 1 1 0 Aspartyl protease RT_RNaseH PF17917.1 CCF51518.1 - 0.042 14.1 0.0 0.09 13.1 0.0 1.6 1 0 0 1 1 1 0 RNase H-like domain found in reverse transcriptase zf-CCHC_3 PF13917.6 CCF51519.1 - 3.9e-05 23.5 0.2 0.00013 21.9 0.2 1.8 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_2 PF13696.6 CCF51519.1 - 0.00031 20.5 3.9 0.00077 19.2 3.9 1.7 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC PF00098.23 CCF51519.1 - 0.0017 18.3 1.6 0.0035 17.4 1.6 1.6 1 0 0 1 1 1 1 Zinc knuckle eIF3g PF12353.8 CCF51519.1 - 0.1 13.0 0.3 0.17 12.3 0.3 1.3 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit G MFS_1 PF07690.16 CCF51520.1 - 1.3e-25 90.1 31.0 1.3e-24 86.8 25.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Phos_pyr_kin PF08543.12 CCF51522.1 - 1.5e-73 247.2 2.2 3.5e-54 183.8 0.1 3.4 3 1 0 3 3 3 2 Phosphomethylpyrimidine kinase TENA_THI-4 PF03070.16 CCF51522.1 - 1.4e-32 113.3 0.2 2.2e-32 112.6 0.2 1.3 1 0 0 1 1 1 1 TENA/THI-4/PQQC family HK PF02110.15 CCF51522.1 - 0.012 15.0 0.1 4.9 6.4 0.1 2.6 2 0 0 2 2 2 0 Hydroxyethylthiazole kinase family PfkB PF00294.24 CCF51522.1 - 0.064 12.5 0.0 0.26 10.5 0.0 1.9 2 0 0 2 2 2 0 pfkB family carbohydrate kinase Peptidase_S49 PF01343.18 CCF51523.1 - 1.6e-43 148.3 0.0 3.7e-25 88.7 0.0 2.7 3 0 0 3 3 3 2 Peptidase family S49 CLP_protease PF00574.23 CCF51523.1 - 2e-05 24.6 0.1 0.00029 20.8 0.1 2.5 2 0 0 2 2 2 1 Clp protease SDH_sah PF01972.16 CCF51523.1 - 0.0087 15.1 0.0 0.022 13.7 0.0 1.6 1 0 0 1 1 1 1 Serine dehydrogenase proteinase Aminotran_5 PF00266.19 CCF51524.1 - 2.9e-21 75.9 0.0 5.4e-15 55.2 0.0 2.3 2 0 0 2 2 2 2 Aminotransferase class-V MOSC PF03473.17 CCF51524.1 - 7.9e-20 71.2 0.0 2.7e-19 69.5 0.0 1.9 1 1 0 1 1 1 1 MOSC domain MOSC_N PF03476.16 CCF51524.1 - 2.8e-18 65.9 0.0 6.9e-18 64.7 0.0 1.7 1 0 0 1 1 1 1 MOSC N-terminal beta barrel domain DAP3 PF10236.9 CCF51526.1 - 0.12 11.5 0.0 0.2 10.8 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 HTH_21 PF13276.6 CCF51526.1 - 4.8 7.4 7.0 23 5.2 4.3 2.3 1 1 1 2 2 2 0 HTH-like domain MMS19_N PF14500.6 CCF51527.1 - 2.7e-69 233.7 0.0 1e-67 228.5 0.0 3.3 3 1 0 3 3 3 1 Dos2-interacting transcription regulator of RNA-Pol-II MMS19_C PF12460.8 CCF51527.1 - 1e-56 192.9 0.2 4.1e-56 190.9 0.0 2.2 2 1 0 2 2 2 1 RNAPII transcription regulator C-terminal HEAT_2 PF13646.6 CCF51527.1 - 0.086 13.2 4.8 23 5.5 0.0 4.9 5 0 0 5 5 5 0 HEAT repeats Glyco_H_20C_C PF18088.1 CCF51528.1 - 2.5e-36 125.4 0.2 6.9e-35 120.7 0.0 2.4 2 1 0 2 2 2 1 Glycoside Hydrolase 20C C-terminal domain Glyco_hydro_20 PF00728.22 CCF51528.1 - 5.6e-09 35.8 0.0 3.3e-08 33.3 0.0 2.3 1 1 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Steroid_dh PF02544.16 CCF51529.1 - 2.8e-34 118.3 6.2 3.9e-34 117.8 6.2 1.2 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase ubiquitin PF00240.23 CCF51529.1 - 0.00062 19.5 0.0 0.0011 18.7 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family DUF1295 PF06966.12 CCF51529.1 - 0.0025 17.4 1.6 0.0035 16.9 1.6 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) YukD PF08817.10 CCF51529.1 - 0.016 15.9 0.0 0.026 15.2 0.0 1.3 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukD SET PF00856.28 CCF51530.1 - 1.6e-14 54.7 9.2 3.6e-08 34.0 2.3 3.3 2 2 1 3 3 3 2 SET domain Rubis-subs-bind PF09273.11 CCF51530.1 - 1e-05 26.2 1.0 2.3e-05 25.1 0.1 2.2 2 0 0 2 2 2 1 Rubisco LSMT substrate-binding RRN3 PF05327.11 CCF51530.1 - 0.71 8.3 19.5 1.3 7.5 19.5 1.3 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Zn_clus PF00172.18 CCF51532.1 - 0.00047 20.2 7.9 0.00099 19.2 7.9 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain OHCU_decarbox PF09349.10 CCF51533.1 - 2.9e-25 89.6 0.6 9.9e-25 87.8 0.0 2.1 2 1 1 3 3 3 1 OHCU decarboxylase Y_phosphatase2 PF03162.13 CCF51534.1 - 1.3e-48 164.8 0.0 2.2e-48 163.9 0.0 1.4 1 0 0 1 1 1 1 Tyrosine phosphatase family Prefoldin PF02996.17 CCF51534.1 - 6.4e-30 103.5 0.0 1.1e-29 102.7 0.0 1.4 1 0 0 1 1 1 1 Prefoldin subunit Y_phosphatase3 PF13350.6 CCF51534.1 - 3.4e-07 30.5 0.0 1.3e-06 28.5 0.0 1.9 1 1 0 1 1 1 1 Tyrosine phosphatase family Syntaxin-6_N PF09177.11 CCF51534.1 - 0.082 13.5 1.9 1.4 9.5 0.4 2.7 2 0 0 2 2 2 0 Syntaxin 6, N-terminal Y_phosphatase PF00102.27 CCF51534.1 - 0.13 11.8 0.0 0.26 10.8 0.0 1.4 1 0 0 1 1 1 0 Protein-tyrosine phosphatase LRR_4 PF12799.7 CCF51535.1 - 0.0042 17.5 2.9 0.77 10.3 0.5 3.1 3 1 0 3 3 3 2 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 CCF51535.1 - 0.013 15.5 0.5 0.94 9.7 0.0 3.5 4 0 0 4 4 4 0 Leucine Rich repeat LRR_8 PF13855.6 CCF51535.1 - 0.36 10.6 4.1 9.8 6.0 0.1 3.8 3 1 1 4 4 4 0 Leucine rich repeat Annexin PF00191.20 CCF51536.1 - 5.7e-57 189.7 2.1 3.5e-17 62.2 0.0 4.9 4 1 0 4 4 4 4 Annexin Alk_phosphatase PF00245.20 CCF51537.1 - 6.7e-73 246.0 0.0 7.1e-72 242.6 0.0 2.0 1 1 0 1 1 1 1 Alkaline phosphatase Ribosomal_L30_N PF08079.12 CCF51538.1 - 7.5e-28 96.6 16.1 1.2e-27 95.9 16.1 1.3 1 0 0 1 1 1 1 Ribosomal L30 N-terminal domain Ribosomal_L30 PF00327.20 CCF51538.1 - 3.1e-17 62.2 2.1 6e-17 61.3 2.1 1.5 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e APG12 PF04110.13 CCF51539.1 - 1.5e-31 108.6 0.1 2.3e-31 108.0 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 Atg8 PF02991.16 CCF51539.1 - 0.008 16.4 0.0 0.01 16.0 0.0 1.3 1 1 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like Ufm1 PF03671.14 CCF51539.1 - 0.012 15.7 0.0 0.022 14.8 0.0 1.5 1 1 0 1 1 1 0 Ubiquitin fold modifier 1 protein FAD_binding_1 PF00667.20 CCF51540.1 - 2.6e-55 187.4 0.0 5.5e-55 186.3 0.0 1.6 2 0 0 2 2 2 1 FAD binding domain NAD_binding_1 PF00175.21 CCF51540.1 - 3.2e-06 27.7 0.0 1.7e-05 25.4 0.0 2.3 2 1 0 2 2 2 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 CCF51540.1 - 0.18 12.2 0.0 2.5 8.5 0.0 2.3 2 0 0 2 2 2 0 Oxidoreductase FAD-binding domain Adeno_E3_CR2 PF02439.15 CCF51541.1 - 0.043 13.6 0.1 0.085 12.6 0.1 1.4 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 TMEM154 PF15102.6 CCF51541.1 - 0.051 13.5 0.0 0.15 12.0 0.0 1.7 1 0 0 1 1 1 0 TMEM154 protein family SKG6 PF08693.10 CCF51542.1 - 0.0014 18.0 0.1 0.0047 16.3 0.1 2.0 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Amnionless PF14828.6 CCF51542.1 - 0.057 12.2 0.0 0.1 11.4 0.0 1.3 1 0 0 1 1 1 0 Amnionless EphA2_TM PF14575.6 CCF51542.1 - 0.08 13.8 0.1 0.38 11.7 0.0 2.1 3 0 0 3 3 3 0 Ephrin type-A receptor 2 transmembrane domain TMEM154 PF15102.6 CCF51542.1 - 0.14 12.1 0.0 0.14 12.1 0.0 3.8 3 2 1 4 4 4 0 TMEM154 protein family FAM163 PF15069.6 CCF51542.1 - 0.36 11.2 0.0 0.36 11.2 0.0 2.5 3 0 0 3 3 3 0 FAM163 family ATP19 PF11022.8 CCF51542.1 - 3.6 8.0 0.0 3.6 8.0 0.0 3.8 3 1 0 3 3 3 0 ATP synthase subunit K FAM176 PF14851.6 CCF51543.1 - 0.095 12.4 1.6 0.17 11.5 1.6 1.4 1 0 0 1 1 1 0 FAM176 family PEARLI-4 PF05278.12 CCF51544.1 - 0.088 12.4 2.7 0.15 11.6 2.7 1.3 1 0 0 1 1 1 0 Arabidopsis phospholipase-like protein (PEARLI 4) Thiolase_N PF00108.23 CCF51545.1 - 8.8e-94 313.7 4.7 1.7e-93 312.8 4.7 1.5 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 CCF51545.1 - 6.6e-46 155.0 1.8 1.2e-44 150.9 1.0 2.5 2 0 0 2 2 2 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 CCF51545.1 - 9e-07 28.7 3.6 9.3e-05 22.1 1.1 3.1 2 1 1 3 3 3 2 Beta-ketoacyl synthase, N-terminal domain BcrAD_BadFG PF01869.20 CCF51545.1 - 0.0049 16.4 0.6 0.018 14.6 0.1 2.1 2 1 0 2 2 2 1 BadF/BadG/BcrA/BcrD ATPase family Dodecin PF07311.12 CCF51545.1 - 0.63 10.3 3.4 5.6 7.3 0.0 3.3 4 0 0 4 4 4 0 Dodecin zf-C2H2 PF00096.26 CCF51546.1 - 5.3e-11 42.3 19.1 7.3e-06 26.2 0.3 4.0 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CCF51546.1 - 5e-07 30.0 14.2 0.0076 17.0 0.2 3.5 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_6 PF13912.6 CCF51546.1 - 1.1e-05 25.3 2.4 0.00028 20.8 0.0 2.4 2 0 0 2 2 2 1 C2H2-type zinc finger zf-H2C2_2 PF13465.6 CCF51546.1 - 0.0017 18.7 13.9 0.069 13.6 0.6 4.6 5 0 0 5 5 5 2 Zinc-finger double domain zf_ZIC PF18366.1 CCF51546.1 - 0.19 11.9 0.1 5.8 7.1 0.0 2.6 2 0 0 2 2 2 0 Zic proteins zinc finger domain zf-C2H2_jaz PF12171.8 CCF51546.1 - 0.22 11.8 2.8 0.58 10.5 0.1 2.8 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.12 CCF51546.1 - 0.42 11.0 4.1 6.8 7.1 4.7 2.3 1 1 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding Med7 PF05983.11 CCF51547.1 - 0.0019 18.3 0.0 0.0026 17.9 0.0 1.3 1 0 0 1 1 1 1 MED7 protein XPA_C PF05181.12 CCF51547.1 - 0.0091 15.9 0.0 0.02 14.8 0.0 1.6 1 0 0 1 1 1 1 XPA protein C-terminus DUF3408 PF11888.8 CCF51547.1 - 0.015 15.4 0.2 0.021 14.9 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) Arm-DNA-bind_3 PF13356.6 CCF51547.1 - 0.06 13.7 1.6 1.3 9.4 1.0 2.4 2 0 0 2 2 2 0 Arm DNA-binding domain SKN1 PF03935.15 CCF51549.1 - 3.4e-202 672.3 0.5 4.3e-202 672.0 0.5 1.1 1 0 0 1 1 1 1 Beta-glucan synthesis-associated protein (SKN1) Glyco_hydro_16 PF00722.21 CCF51549.1 - 0.0012 18.3 0.1 0.0067 15.9 0.0 2.2 2 0 0 2 2 2 1 Glycosyl hydrolases family 16 Sas10_Utp3 PF04000.15 CCF51550.1 - 3.4e-11 43.6 0.0 9.4e-11 42.2 0.0 1.8 1 0 0 1 1 1 1 Sas10/Utp3/C1D family GDI PF00996.18 CCF51551.1 - 3.2e-33 114.9 0.0 9.3e-21 73.8 0.0 2.6 2 1 1 3 3 3 2 GDP dissociation inhibitor AAA PF00004.29 CCF51552.1 - 2.8e-86 286.6 0.0 6.7e-43 146.3 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 CCF51552.1 - 1e-27 95.7 5.5 3.7e-13 49.1 0.5 2.9 3 0 0 3 3 2 2 AAA+ lid domain AAA_5 PF07728.14 CCF51552.1 - 4.2e-16 59.2 0.5 2.3e-08 34.1 0.3 4.1 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 CCF51552.1 - 1e-11 44.9 0.0 4.2e-05 23.4 0.0 3.0 2 1 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 CCF51552.1 - 1.6e-11 44.9 7.5 3.9e-05 24.1 3.9 4.8 2 2 0 2 2 2 2 AAA ATPase domain TIP49 PF06068.13 CCF51552.1 - 2e-08 33.9 0.0 0.0055 16.0 0.0 2.4 2 0 0 2 2 2 2 TIP49 P-loop domain AAA_33 PF13671.6 CCF51552.1 - 3.7e-08 33.7 0.0 0.00046 20.4 0.0 2.8 2 2 0 2 2 2 2 AAA domain AAA_22 PF13401.6 CCF51552.1 - 2.5e-07 31.1 1.6 0.0095 16.2 0.2 4.3 2 2 0 2 2 2 1 AAA domain AAA_18 PF13238.6 CCF51552.1 - 8.9e-06 26.3 0.0 0.015 15.8 0.0 3.5 4 0 0 4 4 3 1 AAA domain IstB_IS21 PF01695.17 CCF51552.1 - 1e-05 25.4 0.0 0.025 14.3 0.0 2.7 2 0 0 2 2 2 2 IstB-like ATP binding protein RNA_helicase PF00910.22 CCF51552.1 - 1.6e-05 25.2 0.0 0.15 12.4 0.0 2.6 2 0 0 2 2 2 2 RNA helicase AAA_2 PF07724.14 CCF51552.1 - 1.8e-05 24.9 0.0 0.35 11.0 0.0 3.1 2 2 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_28 PF13521.6 CCF51552.1 - 2.2e-05 24.8 2.3 0.031 14.5 0.5 3.4 3 1 0 3 3 3 2 AAA domain Rad17 PF03215.15 CCF51552.1 - 3e-05 24.0 0.0 0.072 13.0 0.0 3.2 2 1 1 3 3 3 1 Rad17 P-loop domain AAA_14 PF13173.6 CCF51552.1 - 3.3e-05 23.9 0.0 0.04 14.0 0.0 2.5 2 0 0 2 2 2 2 AAA domain Mg_chelatase PF01078.21 CCF51552.1 - 9.6e-05 21.9 1.6 0.26 10.6 0.1 2.8 3 0 0 3 3 2 2 Magnesium chelatase, subunit ChlI TsaE PF02367.17 CCF51552.1 - 0.00026 21.0 0.0 0.16 12.0 0.0 2.5 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_3 PF07726.11 CCF51552.1 - 0.00062 19.6 0.1 2.3 8.1 0.0 3.2 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 CCF51552.1 - 0.00065 19.3 0.0 0.22 11.0 0.0 2.4 2 0 0 2 2 2 1 P-loop containing dynein motor region Sigma54_activ_2 PF14532.6 CCF51552.1 - 0.00065 19.8 0.0 0.44 10.6 0.0 2.6 2 0 0 2 2 2 1 Sigma-54 interaction domain CDC48_N PF02359.18 CCF51552.1 - 0.00067 19.8 0.0 0.003 17.7 0.0 2.0 2 0 0 2 2 1 1 Cell division protein 48 (CDC48), N-terminal domain Zeta_toxin PF06414.12 CCF51552.1 - 0.0016 17.7 0.1 0.068 12.4 0.0 2.5 2 0 0 2 2 2 1 Zeta toxin AAA_24 PF13479.6 CCF51552.1 - 0.0018 18.0 0.0 0.06 13.1 0.0 2.3 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 CCF51552.1 - 0.0019 18.1 0.2 0.096 12.6 0.1 3.1 2 1 0 2 2 2 1 NACHT domain Sigma54_activat PF00158.26 CCF51552.1 - 0.0023 17.7 0.0 2.2 7.9 0.0 3.7 3 1 0 3 3 2 1 Sigma-54 interaction domain Parvo_NS1 PF01057.17 CCF51552.1 - 0.0027 16.9 0.0 0.31 10.1 0.0 2.2 2 0 0 2 2 2 1 Parvovirus non-structural protein NS1 DUF815 PF05673.13 CCF51552.1 - 0.0053 15.9 0.0 0.058 12.5 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_25 PF13481.6 CCF51552.1 - 0.0073 15.9 7.1 0.24 11.0 0.2 3.8 2 2 2 4 4 4 1 AAA domain AAA_11 PF13086.6 CCF51552.1 - 0.0074 16.1 0.0 0.82 9.4 0.0 2.6 2 0 0 2 2 2 1 AAA domain ATPase PF06745.13 CCF51552.1 - 0.013 14.8 0.2 7.1 5.9 0.0 3.2 3 0 0 3 3 3 0 KaiC ABC_tran PF00005.27 CCF51552.1 - 0.024 15.1 0.0 1.4 9.5 0.0 2.7 2 0 0 2 2 2 0 ABC transporter ATPase_2 PF01637.18 CCF51552.1 - 0.027 14.4 0.2 3.3 7.6 0.0 3.1 2 2 2 4 4 4 0 ATPase domain predominantly from Archaea AAA_30 PF13604.6 CCF51552.1 - 0.03 14.0 1.4 0.54 9.9 0.0 3.3 3 0 0 3 3 3 0 AAA domain PhoH PF02562.16 CCF51552.1 - 0.033 13.6 0.2 1.1 8.7 0.2 2.4 2 0 0 2 2 2 0 PhoH-like protein AAA_23 PF13476.6 CCF51552.1 - 0.05 14.1 0.0 0.13 12.7 0.0 1.7 2 0 0 2 2 1 0 AAA domain Cytidylate_kin PF02224.18 CCF51552.1 - 0.057 13.2 0.5 1.2 8.8 0.1 2.7 2 0 0 2 2 2 0 Cytidylate kinase IPT PF01745.16 CCF51552.1 - 0.082 12.3 0.2 1.8 7.9 0.2 2.3 2 0 0 2 2 2 0 Isopentenyl transferase DAP3 PF10236.9 CCF51552.1 - 0.083 12.0 0.0 0.56 9.3 0.0 2.2 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 NTPase_1 PF03266.15 CCF51552.1 - 0.17 11.8 0.2 5.8 6.8 0.0 3.0 2 1 1 3 3 3 0 NTPase Adeno_IVa2 PF02456.15 CCF51552.1 - 0.2 10.4 0.1 3.7 6.2 0.0 2.7 3 0 0 3 3 3 0 Adenovirus IVa2 protein DUF5570 PF17731.1 CCF51553.1 - 0.027 14.6 0.3 0.32 11.1 0.1 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5570) Abhydrolase_1 PF00561.20 CCF51556.1 - 1.8e-26 93.4 0.0 2.5e-26 92.9 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CCF51556.1 - 7e-11 43.2 0.5 9.6e-11 42.7 0.5 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CCF51556.1 - 1.3e-06 27.9 0.0 1.8e-06 27.4 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 DUF3530 PF12048.8 CCF51556.1 - 0.0015 18.0 0.0 0.0024 17.3 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3530) EHN PF06441.12 CCF51556.1 - 0.0015 18.9 0.3 0.0052 17.1 0.2 1.9 2 0 0 2 2 2 1 Epoxide hydrolase N terminus Ndr PF03096.14 CCF51556.1 - 0.0021 16.8 0.0 0.0035 16.1 0.0 1.3 1 0 0 1 1 1 1 Ndr family DUF2914 PF11141.8 CCF51556.1 - 0.15 11.8 0.2 2.1 8.2 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2914) DASH_Dad3 PF08656.10 CCF51557.1 - 9.6e-20 70.4 1.7 1.8e-19 69.6 1.7 1.4 1 0 0 1 1 1 1 DASH complex subunit Dad3 MetOD2 PF18548.1 CCF51557.1 - 0.015 15.4 0.2 5.6 7.1 0.0 2.4 1 1 1 2 2 2 0 Metanogen output domain 2 DUF3619 PF12279.8 CCF51557.1 - 0.083 13.2 1.6 0.11 12.9 1.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3619) adh_short PF00106.25 CCF51559.1 - 1.2e-52 178.3 0.0 1.5e-52 177.9 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF51559.1 - 1.7e-34 119.4 0.0 2.1e-34 119.1 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF51559.1 - 1.7e-13 50.9 0.0 2e-13 50.6 0.0 1.1 1 0 0 1 1 1 1 KR domain GDP_Man_Dehyd PF16363.5 CCF51559.1 - 0.00027 20.5 0.0 0.00035 20.1 0.0 1.3 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 CCF51559.1 - 0.00045 19.8 0.0 0.00075 19.0 0.0 1.5 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3HCDH_N PF02737.18 CCF51559.1 - 0.00081 19.3 0.2 0.0013 18.7 0.2 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 2-Hacid_dh_C PF02826.19 CCF51559.1 - 0.00092 18.6 0.0 0.0017 17.7 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain THF_DHG_CYH_C PF02882.19 CCF51559.1 - 0.0065 15.8 0.1 0.015 14.6 0.0 1.6 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Eno-Rase_NADH_b PF12242.8 CCF51559.1 - 0.02 14.6 0.1 0.038 13.7 0.1 1.4 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase ApbA PF02558.16 CCF51559.1 - 0.088 12.5 0.2 0.14 11.8 0.2 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA NAD_binding_10 PF13460.6 CCF51559.1 - 0.11 12.4 0.1 0.21 11.5 0.1 1.7 1 1 0 1 1 1 0 NAD(P)H-binding Polysacc_synt_2 PF02719.15 CCF51559.1 - 0.12 11.5 0.0 0.28 10.3 0.0 1.6 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein ThiF PF00899.21 CCF51559.1 - 0.13 11.6 0.1 0.22 10.8 0.1 1.2 1 0 0 1 1 1 0 ThiF family XPG_I PF00867.18 CCF51561.1 - 8e-24 83.8 0.0 2e-23 82.6 0.0 1.7 1 0 0 1 1 1 1 XPG I-region XPG_N PF00752.17 CCF51561.1 - 1.9e-21 76.4 0.0 3.9e-21 75.4 0.0 1.5 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I_2 PF12813.7 CCF51561.1 - 3e-06 26.9 0.0 5.6e-06 26.0 0.0 1.3 1 0 0 1 1 1 1 XPG domain containing 5_3_exonuc PF01367.20 CCF51561.1 - 0.057 14.0 0.0 0.14 12.8 0.0 1.6 1 0 0 1 1 1 0 5'-3' exonuclease, C-terminal SAM fold Adeno_E1B_55K PF01696.17 CCF51561.1 - 0.12 11.1 0.0 0.2 10.3 0.0 1.3 1 0 0 1 1 1 0 Adenovirus EB1 55K protein / large t-antigen TPR_14 PF13428.6 CCF51561.1 - 0.13 13.2 0.2 0.41 11.6 0.2 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat LSM PF01423.22 CCF51562.1 - 4.3e-18 64.8 0.6 5.4e-18 64.5 0.6 1.1 1 0 0 1 1 1 1 LSM domain Gemin7 PF11095.8 CCF51562.1 - 0.074 12.9 0.0 0.11 12.4 0.0 1.2 1 0 0 1 1 1 0 Gem-associated protein 7 (Gemin7) BPL_C PF02237.17 CCF51562.1 - 0.075 12.9 0.8 0.19 11.7 0.5 1.8 2 0 0 2 2 2 0 Biotin protein ligase C terminal domain DUF4826 PF16108.5 CCF51562.1 - 0.18 12.1 0.0 0.24 11.7 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4826) Redoxin PF08534.10 CCF51563.1 - 1.5e-08 34.5 0.0 1.9e-08 34.1 0.0 1.2 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 CCF51563.1 - 1.2e-06 28.4 0.0 2.1e-05 24.5 0.0 2.0 2 0 0 2 2 2 1 AhpC/TSA family WD40 PF00400.32 CCF51564.1 - 3.4e-22 78.3 12.5 0.0027 18.5 0.0 6.5 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF51564.1 - 1e-05 25.8 0.0 0.022 15.0 0.0 3.3 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain DUF2415 PF10313.9 CCF51564.1 - 0.0015 18.4 0.0 0.015 15.3 0.0 2.6 3 0 0 3 3 3 1 Uncharacterised protein domain (DUF2415) Ge1_WD40 PF16529.5 CCF51564.1 - 0.017 14.1 0.2 1.2 8.0 0.0 2.6 2 1 1 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein DAZAP2 PF11029.8 CCF51564.1 - 0.024 15.6 1.0 0.043 14.8 1.0 1.4 1 0 0 1 1 1 0 DAZ associated protein 2 (DAZAP2) gag_pre-integrs PF13976.6 CCF51564.1 - 0.71 9.8 1.9 39 4.2 0.3 3.0 3 0 0 3 3 3 0 GAG-pre-integrase domain Mtc PF03820.17 CCF51565.1 - 3.6e-114 381.0 0.5 4.2e-114 380.8 0.5 1.0 1 0 0 1 1 1 1 Tricarboxylate carrier L_protein_N PF15518.6 CCF51565.1 - 0.02 14.7 0.0 0.04 13.7 0.0 1.4 1 0 0 1 1 1 0 L protein N-terminus FA_hydroxylase PF04116.13 CCF51566.1 - 1.2e-23 83.9 19.2 1.5e-23 83.6 16.3 2.1 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily PHP PF02811.19 CCF51567.1 - 7.1e-07 29.7 0.2 2.3e-06 28.0 0.2 1.8 1 1 0 1 1 1 1 PHP domain RNA_pol_I_A49 PF06870.12 CCF51568.1 - 8.1e-112 373.9 0.3 1.1e-111 373.5 0.0 1.3 2 0 0 2 2 2 1 A49-like RNA polymerase I associated factor Pap_E4 PF02711.14 CCF51568.1 - 1.7 9.6 3.5 5.4 8.0 3.5 1.8 1 0 0 1 1 1 0 E4 protein Peptidase_M48_N PF16491.5 CCF51569.1 - 1.2e-62 211.0 6.5 1.2e-62 211.0 6.5 1.6 2 0 0 2 2 2 1 CAAX prenyl protease N-terminal, five membrane helices Peptidase_M48 PF01435.18 CCF51569.1 - 1.4e-33 116.3 0.8 1.4e-31 109.8 0.8 2.9 1 1 0 1 1 1 1 Peptidase family M48 Peptidase_M56 PF05569.11 CCF51569.1 - 0.025 13.8 0.4 0.025 13.8 0.4 2.3 2 1 1 3 3 3 0 BlaR1 peptidase M56 SprT-like PF10263.9 CCF51569.1 - 0.028 14.3 0.0 0.06 13.2 0.0 1.5 1 0 0 1 1 1 0 SprT-like family Fungal_trans PF04082.18 CCF51570.1 - 1e-43 149.3 0.0 1.6e-43 148.7 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-C2H2 PF00096.26 CCF51570.1 - 2.5e-08 33.9 10.6 0.0011 19.3 1.8 3.0 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CCF51570.1 - 9.2e-06 26.1 8.1 0.016 16.0 1.0 3.1 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_8 PF15909.5 CCF51570.1 - 0.24 11.7 1.4 0.54 10.6 1.4 1.5 1 0 0 1 1 1 0 C2H2-type zinc ribbon zf-H2C2_2 PF13465.6 CCF51570.1 - 0.29 11.6 4.7 0.16 12.5 1.1 2.3 2 0 0 2 2 2 0 Zinc-finger double domain zf-C2H2_6 PF13912.6 CCF51570.1 - 1.2 9.2 4.5 0.25 11.4 0.3 2.1 2 0 0 2 2 2 0 C2H2-type zinc finger SpoIIE PF07228.12 CCF51571.1 - 1.1e-06 28.6 0.1 0.21 11.5 0.0 3.4 3 0 0 3 3 3 2 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.6 CCF51571.1 - 6.8e-05 22.6 0.2 0.00034 20.3 0.2 2.1 1 1 0 1 1 1 1 Protein phosphatase 2C PP2C PF00481.21 CCF51571.1 - 0.0012 18.6 0.1 0.027 14.1 0.0 2.5 2 0 0 2 2 2 1 Protein phosphatase 2C Cu-oxidase_3 PF07732.15 CCF51572.1 - 5.6e-38 129.6 4.4 3.9e-37 126.9 1.1 3.5 4 0 0 4 4 4 1 Multicopper oxidase Cu-oxidase_2 PF07731.14 CCF51572.1 - 8.3e-34 116.3 9.1 3.4e-30 104.6 0.4 4.1 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase PF00394.22 CCF51572.1 - 1e-33 116.7 0.1 1.5e-32 112.9 0.0 2.4 2 0 0 2 2 2 1 Multicopper oxidase N_BRCA1_IG PF16158.5 CCF51572.1 - 0.084 13.6 0.0 0.28 11.9 0.0 1.9 1 0 0 1 1 1 0 Ig-like domain from next to BRCA1 gene Phosphoesterase PF04185.14 CCF51573.1 - 1.3e-28 100.3 1.3 5.2e-28 98.3 1.3 1.8 1 1 0 1 1 1 1 Phosphoesterase family CoA_transf_3 PF02515.17 CCF51573.1 - 0.14 11.3 0.1 0.19 10.8 0.1 1.2 1 0 0 1 1 1 0 CoA-transferase family III zf-C2H2 PF00096.26 CCF51575.1 - 6e-05 23.3 16.5 0.00047 20.5 2.4 3.2 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CCF51575.1 - 0.00032 21.3 10.3 0.013 16.3 1.6 3.1 2 0 0 2 2 2 2 C2H2-type zinc finger FOXP-CC PF16159.5 CCF51575.1 - 0.17 12.6 1.6 3 8.6 0.2 2.7 1 1 1 2 2 2 0 FOXP coiled-coil domain zf-C2H2_8 PF15909.5 CCF51575.1 - 0.62 10.4 5.0 2.4 8.5 5.0 2.0 1 0 0 1 1 1 0 C2H2-type zinc ribbon GTP_EFTU PF00009.27 CCF51576.1 - 1.5e-58 197.6 0.1 2.7e-58 196.7 0.1 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 CCF51576.1 - 1.1e-36 125.3 0.1 3.9e-36 123.5 0.1 2.0 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_II PF14492.6 CCF51576.1 - 4.3e-31 106.8 0.0 1e-30 105.7 0.0 1.7 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.24 CCF51576.1 - 2.6e-22 78.7 0.2 6.1e-22 77.5 0.2 1.7 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 CCF51576.1 - 1e-13 51.5 0.0 2.6e-13 50.1 0.0 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 RF3_C PF16658.5 CCF51576.1 - 5.1e-07 29.6 0.0 1.2e-06 28.4 0.0 1.5 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain BAT PF15915.5 CCF51576.1 - 0.69 9.8 4.3 23 4.8 0.0 3.5 3 1 0 3 3 3 0 GAF and HTH_10 associated domain SKN1 PF03935.15 CCF51577.1 - 1.1e-178 594.8 3.3 1.3e-178 594.5 3.3 1.0 1 0 0 1 1 1 1 Beta-glucan synthesis-associated protein (SKN1) SKN1 PF03935.15 CCF51579.1 - 4.5e-190 632.3 6.0 5.3e-190 632.1 6.0 1.0 1 0 0 1 1 1 1 Beta-glucan synthesis-associated protein (SKN1) Rot1 PF10681.9 CCF51580.1 - 1.5e-45 155.3 0.2 1.9e-45 155.0 0.2 1.0 1 0 0 1 1 1 1 Chaperone for protein-folding within the ER, fungal SKN1 PF03935.15 CCF51581.1 - 1.9e-182 607.2 0.8 2.2e-182 607.0 0.8 1.0 1 0 0 1 1 1 1 Beta-glucan synthesis-associated protein (SKN1) FMO-like PF00743.19 CCF51582.1 - 2.2e-18 66.0 0.1 5.3e-16 58.1 0.0 2.3 2 0 0 2 2 2 2 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.14 CCF51582.1 - 5e-18 65.4 0.0 2.5e-13 50.0 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 CCF51582.1 - 2.3e-11 43.4 0.0 9.4e-10 38.1 0.0 2.2 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_3 PF13738.6 CCF51582.1 - 4.2e-10 39.4 0.0 2.8e-06 26.8 0.0 2.5 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CCF51582.1 - 1.2e-08 35.0 1.7 0.037 13.6 0.1 3.3 2 1 0 3 3 3 3 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CCF51582.1 - 1.8e-08 34.5 0.3 2.8e-07 30.6 0.0 2.8 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 CCF51582.1 - 1.5e-06 28.7 0.2 0.056 14.0 0.2 2.7 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CCF51582.1 - 4.6e-05 23.5 4.0 0.15 12.0 0.0 4.3 5 0 0 5 5 5 2 FAD-NAD(P)-binding GIDA PF01134.22 CCF51582.1 - 0.00011 21.4 1.1 0.036 13.2 0.0 2.5 3 0 0 3 3 3 2 Glucose inhibited division protein A HI0933_like PF03486.14 CCF51582.1 - 0.0011 17.7 0.6 0.043 12.5 0.0 2.9 3 0 0 3 3 3 1 HI0933-like protein Thi4 PF01946.17 CCF51582.1 - 0.018 14.3 0.1 0.89 8.7 0.0 2.3 2 0 0 2 2 2 0 Thi4 family AlaDh_PNT_C PF01262.21 CCF51582.1 - 0.097 12.0 0.2 0.68 9.2 0.0 2.0 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain FAD_binding_2 PF00890.24 CCF51582.1 - 0.46 9.5 0.0 0.46 9.5 0.0 1.7 2 0 0 2 2 1 0 FAD binding domain AMP-binding PF00501.28 CCF51583.1 - 5.9e-80 268.9 0.0 7.5e-80 268.6 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 CCF51583.1 - 8.5e-12 45.9 0.0 2e-11 44.7 0.0 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain TAFII28 PF04719.14 CCF51584.1 - 2.3e-30 104.5 0.3 3.8e-30 103.8 0.3 1.3 1 0 0 1 1 1 1 hTAFII28-like protein conserved region Sacchrp_dh_C PF16653.5 CCF51585.1 - 9e-92 307.9 0.0 1.5e-91 307.2 0.0 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase C-terminal domain Spermine_synth PF01564.17 CCF51585.1 - 2.3e-66 222.8 0.0 1.1e-65 220.6 0.0 2.0 2 0 0 2 2 2 1 Spermine/spermidine synthase domain Sacchrp_dh_NADP PF03435.18 CCF51585.1 - 1.5e-23 83.5 1.1 3.8e-23 82.2 0.2 2.0 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain Spermine_synt_N PF17284.2 CCF51585.1 - 3e-23 81.5 0.1 5.5e-23 80.6 0.1 1.5 1 0 0 1 1 1 1 Spermidine synthase tetramerisation domain Methyltransf_25 PF13649.6 CCF51585.1 - 0.00044 20.9 0.0 0.0037 17.9 0.0 2.5 3 0 0 3 3 3 1 Methyltransferase domain NAD_binding_10 PF13460.6 CCF51585.1 - 0.014 15.3 0.1 0.026 14.4 0.1 1.4 1 0 0 1 1 1 0 NAD(P)H-binding Semialdhyde_dh PF01118.24 CCF51585.1 - 0.019 15.4 0.1 0.062 13.7 0.1 2.0 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain Methyltransf_12 PF08242.12 CCF51585.1 - 0.041 14.6 0.1 0.23 12.2 0.0 2.4 2 1 0 2 2 2 0 Methyltransferase domain RVT_1 PF00078.27 CCF51586.1 - 4.1e-07 29.7 0.0 7.2e-07 28.9 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF4245 PF14030.6 CCF51586.1 - 1.1 9.2 6.2 4.5 7.2 4.8 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF4245) Phage_integrase PF00589.22 CCF51587.1 - 0.019 14.8 0.0 0.032 14.0 0.0 1.3 1 0 0 1 1 1 0 Phage integrase family DASH_Duo1 PF08651.10 CCF51589.1 - 0.04 13.7 0.0 0.066 13.0 0.0 1.2 1 0 0 1 1 1 0 DASH complex subunit Duo1 Zn_clus PF00172.18 CCF51590.1 - 3.4e-05 23.9 13.5 5.4e-05 23.2 13.5 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CENP-K PF11802.8 CCF51591.1 - 2.1e-09 37.3 15.2 5.1e-07 29.5 12.8 3.0 1 1 1 2 2 2 1 Centromere-associated protein K FeoC PF09012.10 CCF51591.1 - 0.025 14.6 1.7 0.15 12.1 0.0 3.0 4 0 0 4 4 4 0 FeoC like transcriptional regulator KHA PF11834.8 CCF51591.1 - 0.048 13.8 0.0 11 6.2 0.0 2.9 3 0 0 3 3 3 0 KHA, dimerisation domain of potassium ion channel MetOD2 PF18548.1 CCF51591.1 - 1.1 9.4 7.3 1.2 9.3 0.3 3.1 3 0 0 3 3 3 0 Metanogen output domain 2 ResIII PF04851.15 CCF51592.1 - 1.3e-22 80.6 0.0 2.5e-22 79.7 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 CCF51592.1 - 9.9e-16 58.1 0.0 7.1e-15 55.3 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 CCF51592.1 - 3.5e-12 46.4 0.0 7.5e-12 45.4 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase T2SSE PF00437.20 CCF51592.1 - 0.00077 18.6 0.0 0.0013 17.8 0.0 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein SWI2_SNF2 PF18766.1 CCF51592.1 - 0.0028 17.3 0.0 0.0047 16.6 0.0 1.4 1 0 0 1 1 1 1 SWI2/SNF2 ATPase cobW PF02492.19 CCF51592.1 - 0.0048 16.5 0.0 0.0083 15.7 0.0 1.3 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain ERCC3_RAD25_C PF16203.5 CCF51592.1 - 0.0076 15.5 0.0 0.013 14.7 0.0 1.2 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase DUF2075 PF09848.9 CCF51592.1 - 0.024 13.9 0.0 0.045 13.0 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) SNF2_N PF00176.23 CCF51592.1 - 0.077 11.7 0.0 0.12 11.1 0.0 1.2 1 0 0 1 1 1 0 SNF2 family N-terminal domain AAA_22 PF13401.6 CCF51592.1 - 0.13 12.5 0.0 0.45 10.8 0.0 1.9 1 0 0 1 1 1 0 AAA domain GDPD PF03009.17 CCF51592.1 - 0.17 11.6 0.0 0.29 10.8 0.0 1.3 1 0 0 1 1 1 0 Glycerophosphoryl diester phosphodiesterase family Na_Ca_ex PF01699.24 CCF51594.1 - 4.9e-37 127.2 35.3 3.5e-20 72.5 12.6 2.5 2 1 0 2 2 2 2 Sodium/calcium exchanger protein Sdh_cyt PF01127.22 CCF51594.1 - 0.087 12.9 6.8 2.7 8.0 0.2 3.7 3 0 0 3 3 3 0 Succinate dehydrogenase/Fumarate reductase transmembrane subunit Pkinase PF00069.25 CCF51595.1 - 4.9e-75 252.3 0.0 6.6e-75 251.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF51595.1 - 6.8e-37 127.1 0.0 1e-36 126.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase AdenylateSensor PF16579.5 CCF51595.1 - 8.3e-19 68.2 0.0 1.6e-09 38.2 0.0 3.5 3 0 0 3 3 3 2 Adenylate sensor of SNF1-like protein kinase Kinase-like PF14531.6 CCF51595.1 - 2.5e-08 33.6 0.0 4e-08 32.9 0.0 1.3 1 0 0 1 1 1 1 Kinase-like UBA_2 PF08587.11 CCF51595.1 - 0.0002 21.4 0.4 0.00045 20.3 0.4 1.6 1 0 0 1 1 1 1 Ubiquitin associated domain (UBA) RIO1 PF01163.22 CCF51595.1 - 0.0051 16.4 0.9 0.0071 16.0 0.0 1.6 2 0 0 2 2 2 1 RIO1 family Haspin_kinase PF12330.8 CCF51595.1 - 0.044 12.7 0.0 0.095 11.6 0.0 1.5 1 0 0 1 1 1 0 Haspin like kinase domain TPR_8 PF13181.6 CCF51596.1 - 1.6e-08 34.1 10.7 0.0007 19.6 0.3 6.0 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_2 PF07719.17 CCF51596.1 - 1.8e-08 33.8 26.2 0.0072 16.4 0.2 8.1 9 0 0 9 9 8 3 Tetratricopeptide repeat TPR_17 PF13431.6 CCF51596.1 - 1.3e-05 25.2 5.7 0.094 13.1 0.0 4.8 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 CCF51596.1 - 4.9e-05 23.8 33.0 0.0062 17.3 2.0 8.0 6 2 2 8 8 8 4 Tetratricopeptide repeat TPR_1 PF00515.28 CCF51596.1 - 5.8e-05 22.7 16.3 0.029 14.2 0.3 5.5 7 0 0 7 7 6 2 Tetratricopeptide repeat ANAPC3 PF12895.7 CCF51596.1 - 0.00035 20.7 11.2 0.0011 19.2 1.5 4.3 5 0 0 5 5 5 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 CCF51596.1 - 0.014 15.9 24.7 0.31 11.6 4.2 6.7 5 1 1 6 6 6 0 Tetratricopeptide repeat TPR_7 PF13176.6 CCF51596.1 - 0.018 15.0 3.8 6.6 7.0 0.0 4.8 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_16 PF13432.6 CCF51596.1 - 0.022 15.4 1.9 0.022 15.4 1.9 7.1 8 2 1 9 9 8 0 Tetratricopeptide repeat TPR_11 PF13414.6 CCF51596.1 - 0.023 14.4 10.6 0.14 11.9 2.1 4.7 5 0 0 5 5 5 0 TPR repeat ChAPs PF09295.10 CCF51596.1 - 0.14 11.1 0.5 0.28 10.2 0.5 1.4 1 0 0 1 1 1 0 ChAPs (Chs5p-Arf1p-binding proteins) TPR_12 PF13424.6 CCF51596.1 - 1 9.7 26.8 2.9 8.3 0.2 7.8 7 2 2 9 9 9 0 Tetratricopeptide repeat Tubulin PF00091.25 CCF51597.1 - 2.8e-69 233.3 0.0 4.6e-69 232.6 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 CCF51597.1 - 1.5e-41 141.5 0.2 2.5e-41 140.8 0.2 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 CCF51597.1 - 3.4e-07 30.6 0.2 8.6e-07 29.3 0.0 1.8 2 0 0 2 2 2 1 Misato Segment II tubulin-like domain Tubulin_3 PF14881.6 CCF51597.1 - 0.0013 18.4 0.0 0.0029 17.3 0.0 1.6 1 0 0 1 1 1 1 Tubulin domain Tubulin_2 PF13809.6 CCF51597.1 - 0.014 14.6 0.1 0.032 13.4 0.0 1.6 2 0 0 2 2 2 0 Tubulin like Mago_nashi PF02792.14 CCF51598.1 - 5.5e-76 253.5 0.3 6.1e-76 253.3 0.3 1.0 1 0 0 1 1 1 1 Mago nashi protein DRY_EERY PF09750.9 CCF51599.1 - 0.0044 17.3 0.1 0.0044 17.3 0.1 2.4 3 1 0 3 3 3 1 Alternative splicing regulator VAPB_antitox PF02697.14 CCF51599.1 - 0.19 12.6 1.0 0.27 12.0 0.0 1.8 2 0 0 2 2 2 0 Putative antitoxin Cpn60_TCP1 PF00118.24 CCF51600.1 - 6.8e-86 288.8 8.5 1.2e-85 288.1 8.5 1.3 1 1 0 1 1 1 1 TCP-1/cpn60 chaperonin family Cpn10 PF00166.21 CCF51601.1 - 1.5e-26 92.3 0.0 1.7e-26 92.1 0.0 1.0 1 0 0 1 1 1 1 Chaperonin 10 Kd subunit Actin PF00022.19 CCF51602.1 - 6.2e-40 137.0 0.0 9.3e-37 126.6 0.0 3.0 2 1 0 2 2 2 2 Actin ThiF PF00899.21 CCF51603.1 - 1.9e-13 50.3 0.0 9.3e-13 48.1 0.0 1.9 1 1 0 1 1 1 1 ThiF family E1_4HB PF16191.5 CCF51603.1 - 0.00045 20.3 0.0 0.019 15.1 0.0 3.0 2 0 0 2 2 2 1 Ubiquitin-activating enzyme E1 four-helix bundle SR-25 PF10500.9 CCF51603.1 - 0.036 13.7 4.9 0.071 12.7 4.9 1.6 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein SMC_N PF02463.19 CCF51604.1 - 2.5e-67 226.5 0.0 1.2e-66 224.3 0.0 2.2 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 CCF51604.1 - 2.3e-21 76.3 0.3 1.3e-20 73.9 0.3 2.4 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 CCF51604.1 - 6.1e-09 36.1 13.0 8.6e-05 22.5 0.1 3.8 4 1 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system Spc7 PF08317.11 CCF51604.1 - 2e-06 26.9 18.2 2e-06 26.9 18.2 6.7 3 2 4 7 7 7 3 Spc7 kinetochore protein Fez1 PF06818.15 CCF51604.1 - 4.6e-06 27.2 40.5 0.00013 22.5 15.7 5.3 2 2 2 5 5 5 2 Fez1 AAA_29 PF13555.6 CCF51604.1 - 8.5e-05 22.2 0.1 0.00099 18.8 0.1 2.4 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_23 PF13476.6 CCF51604.1 - 0.00097 19.7 47.2 0.00097 19.7 47.2 6.8 2 2 0 3 3 2 1 AAA domain TACC_C PF05010.14 CCF51604.1 - 0.0044 16.8 13.9 0.0044 16.8 13.9 6.8 2 2 4 7 7 4 2 Transforming acidic coiled-coil-containing protein (TACC), C-terminal ADIP PF11559.8 CCF51604.1 - 0.0048 17.0 7.6 0.0048 17.0 7.6 8.5 4 3 4 9 9 8 2 Afadin- and alpha -actinin-Binding ABC_tran PF00005.27 CCF51604.1 - 0.061 13.8 0.2 0.061 13.8 0.2 6.4 2 2 1 5 5 5 0 ABC transporter MscS_porin PF12795.7 CCF51604.1 - 1.4 8.4 71.5 0.0092 15.5 12.6 6.5 4 1 2 6 6 6 0 Mechanosensitive ion channel porin domain Filament PF00038.21 CCF51604.1 - 3.9 7.0 86.1 0.048 13.2 9.2 7.2 2 2 4 6 6 6 0 Intermediate filament protein DASH_Dad4 PF08650.10 CCF51604.1 - 9.5 6.3 10.4 0.41 10.7 0.2 4.0 5 0 0 5 5 5 0 DASH complex subunit Dad4 Pirin PF02678.16 CCF51605.1 - 1.3e-26 92.7 1.3 1.3e-26 92.7 1.3 2.1 2 0 0 2 2 2 1 Pirin Cupin_2 PF07883.11 CCF51605.1 - 3.2e-10 39.6 5.8 8.5e-08 31.8 0.5 2.4 2 0 0 2 2 2 2 Cupin domain Cupin_3 PF05899.12 CCF51605.1 - 0.097 12.4 3.8 0.9 9.3 0.9 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF861) AAA_2 PF07724.14 CCF51606.1 - 7.1e-34 117.4 0.0 2.1e-26 93.1 0.0 2.6 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA PF00004.29 CCF51606.1 - 1.7e-13 51.1 0.0 3.3e-13 50.2 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 CCF51606.1 - 3.1e-06 27.5 0.0 9.1e-06 26.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain MCM PF00493.23 CCF51606.1 - 5.1e-06 25.7 0.0 1.2e-05 24.5 0.0 1.5 2 0 0 2 2 2 1 MCM P-loop domain AAA_5 PF07728.14 CCF51606.1 - 9.4e-05 22.4 0.0 0.00039 20.4 0.0 2.0 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) ClpB_D2-small PF10431.9 CCF51606.1 - 0.00016 21.6 0.0 0.0007 19.6 0.0 2.1 1 1 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA_16 PF13191.6 CCF51606.1 - 0.0019 18.6 0.0 0.0064 16.9 0.0 1.9 1 0 0 1 1 1 1 AAA ATPase domain ABC_tran PF00005.27 CCF51606.1 - 0.0034 17.9 0.0 0.0091 16.5 0.0 1.7 1 0 0 1 1 1 1 ABC transporter AAA_33 PF13671.6 CCF51606.1 - 0.0048 17.1 0.0 0.014 15.6 0.0 1.8 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 CCF51606.1 - 0.007 15.8 0.0 0.068 12.6 0.0 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_29 PF13555.6 CCF51606.1 - 0.038 13.7 0.0 0.1 12.4 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain NACHT PF05729.12 CCF51606.1 - 0.04 13.8 0.1 0.11 12.4 0.1 1.7 1 1 0 1 1 1 0 NACHT domain AAA_14 PF13173.6 CCF51606.1 - 0.041 13.9 0.0 0.088 12.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 CCF51606.1 - 0.056 13.2 0.0 0.11 12.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 CCF51606.1 - 0.067 13.2 0.0 0.24 11.4 0.0 1.8 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_3 PF07726.11 CCF51606.1 - 0.068 13.0 0.1 0.19 11.6 0.0 1.8 2 0 0 2 2 1 0 ATPase family associated with various cellular activities (AAA) AAA_21 PF13304.6 CCF51606.1 - 0.07 12.9 0.0 0.17 11.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system T2SSE PF00437.20 CCF51606.1 - 0.088 11.8 0.1 0.2 10.7 0.1 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein CPT PF07931.12 CCF51606.1 - 0.12 12.2 0.0 0.37 10.6 0.0 1.8 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein Ribosomal_60s PF00428.19 CCF51606.1 - 1.9 9.1 18.7 0.23 12.1 1.7 3.8 3 0 0 3 3 3 0 60s Acidic ribosomal protein Pkinase PF00069.25 CCF51607.1 - 2.2e-62 210.8 8.1 1.8e-59 201.2 0.0 2.6 3 0 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 CCF51607.1 - 1.5e-36 126.0 0.0 1.3e-33 116.4 0.0 2.4 2 0 0 2 2 2 2 Protein tyrosine kinase KA1 PF02149.19 CCF51607.1 - 9.5e-17 60.5 0.4 1.6e-16 59.8 0.4 1.4 1 0 0 1 1 1 1 Kinase associated domain 1 Kdo PF06293.14 CCF51607.1 - 3.5e-05 23.3 0.0 7.5e-05 22.2 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 CCF51607.1 - 0.00036 19.9 0.0 0.00036 19.9 0.0 2.0 2 0 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 CCF51607.1 - 0.00042 19.4 0.1 0.00042 19.4 0.1 1.8 2 0 0 2 2 2 1 Haspin like kinase domain APH PF01636.23 CCF51607.1 - 0.004 17.1 7.7 0.0057 16.6 0.0 2.7 2 1 1 3 3 3 1 Phosphotransferase enzyme family WaaY PF06176.11 CCF51607.1 - 0.045 13.4 0.1 0.076 12.6 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) DDHD PF02862.17 CCF51607.1 - 3.1 7.9 10.6 0.085 13.0 2.4 2.7 3 0 0 3 3 3 0 DDHD domain Spt20 PF12090.8 CCF51607.1 - 4.2 6.9 30.1 9 5.8 30.1 1.5 1 0 0 1 1 1 0 Spt20 family MFS_1 PF07690.16 CCF51608.1 - 3.4e-22 78.9 5.7 7.5e-14 51.4 6.1 2.9 3 1 0 3 3 3 2 Major Facilitator Superfamily MscS_TM PF12794.7 CCF51608.1 - 0.071 12.0 0.1 0.071 12.0 0.1 3.0 3 1 0 3 3 3 0 Mechanosensitive ion channel inner membrane domain 1 Sugar_tr PF00083.24 CCF51608.1 - 0.12 11.2 6.3 1.4 7.6 5.9 2.4 2 1 0 2 2 2 0 Sugar (and other) transporter TRAPPC10 PF12584.8 CCF51609.1 - 8.9e-30 103.4 0.0 1.6e-29 102.7 0.0 1.4 1 0 0 1 1 1 1 Trafficking protein particle complex subunit 10, TRAPPC10 DNA_ligase_A_M PF01068.21 CCF51610.1 - 5.4e-58 196.0 0.0 1.5e-57 194.5 0.0 1.8 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 CCF51610.1 - 2.5e-46 158.2 0.4 6.4e-46 156.8 0.4 1.7 1 0 0 1 1 1 1 DNA ligase N terminus DNA_ligase_A_C PF04679.15 CCF51610.1 - 2.7e-23 82.4 0.0 9e-23 80.7 0.0 2.0 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region RNA_ligase PF09414.10 CCF51610.1 - 0.0013 19.1 0.0 0.0031 17.8 0.0 1.7 1 1 0 1 1 1 1 RNA ligase DNA_ligase_OB_2 PF14743.6 CCF51610.1 - 0.015 15.3 0.2 2.8 8.0 0.0 2.6 2 0 0 2 2 2 0 DNA ligase OB-like domain Mito_carr PF00153.27 CCF51611.1 - 8e-71 234.0 0.7 6.1e-24 83.8 0.1 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein EOS1 PF12326.8 CCF51612.1 - 3.8e-70 235.4 0.9 1e-69 234.0 0.0 2.2 2 0 0 2 2 2 1 N-glycosylation protein Carb_kinase PF01256.17 CCF51613.1 - 2.7e-51 174.4 0.0 3.9e-51 173.9 0.0 1.2 1 0 0 1 1 1 1 Carbohydrate kinase Phos_pyr_kin PF08543.12 CCF51613.1 - 0.13 11.6 0.0 0.19 11.0 0.0 1.4 1 0 0 1 1 1 0 Phosphomethylpyrimidine kinase DUF3337 PF11816.8 CCF51614.1 - 6e-51 172.7 0.0 1.1e-50 171.9 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3337) WD40 PF00400.32 CCF51614.1 - 3.2e-18 65.8 25.3 8.5e-05 23.3 0.0 7.0 6 1 0 6 6 6 5 WD domain, G-beta repeat Nup160 PF11715.8 CCF51614.1 - 0.01 14.6 1.1 2.7 6.5 0.1 2.8 2 1 1 3 3 3 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 CCF51614.1 - 0.013 15.8 0.1 1.3 9.4 0.0 3.0 2 1 2 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain DUF3246 PF11596.8 CCF51614.1 - 0.73 9.2 11.9 0.092 12.2 6.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3246) MutS_V PF00488.21 CCF51615.1 - 9.3e-63 211.7 0.0 2e-62 210.6 0.0 1.6 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 CCF51615.1 - 4.6e-37 128.1 5.4 1.5e-36 126.5 3.9 2.6 3 0 0 3 3 3 1 MutS domain III MutS_I PF01624.20 CCF51615.1 - 4e-17 62.5 0.0 8.3e-17 61.5 0.0 1.5 1 0 0 1 1 1 1 MutS domain I MutS_II PF05188.17 CCF51615.1 - 4.7e-06 26.9 0.0 1.5e-05 25.3 0.0 1.9 1 0 0 1 1 1 1 MutS domain II AAA_27 PF13514.6 CCF51615.1 - 0.014 15.0 0.0 0.033 13.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain MitMem_reg PF13012.6 CCF51615.1 - 0.11 12.9 0.0 0.45 11.0 0.0 2.0 1 0 0 1 1 1 0 Maintenance of mitochondrial structure and function FUSC PF04632.12 CCF51615.1 - 0.16 10.5 1.8 0.31 9.5 1.8 1.3 1 0 0 1 1 1 0 Fusaric acid resistance protein family AAA_23 PF13476.6 CCF51615.1 - 0.25 11.8 0.0 0.25 11.8 0.0 2.3 2 1 0 2 2 2 0 AAA domain tRNA-synt_1b PF00579.25 CCF51616.1 - 1.7e-63 214.7 0.0 4.3e-63 213.4 0.0 1.7 2 1 0 2 2 2 1 tRNA synthetases class I (W and Y) tRNA-synt_1e PF01406.19 CCF51616.1 - 0.14 11.5 0.8 0.24 10.7 0.8 1.3 1 0 0 1 1 1 0 tRNA synthetases class I (C) catalytic domain DUF913 PF06025.12 CCF51616.1 - 0.34 9.8 3.9 0.63 9.0 3.9 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Hexapep PF00132.24 CCF51617.1 - 8.2e-11 41.2 6.7 1.3e-08 34.2 4.0 2.4 2 0 0 2 2 2 2 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 CCF51617.1 - 1.2e-10 40.9 6.2 2.3e-08 33.6 2.8 2.3 2 0 0 2 2 2 2 Hexapeptide repeat of succinyl-transferase Mac PF12464.8 CCF51617.1 - 4.1e-08 33.3 0.0 7.5e-08 32.5 0.0 1.4 1 0 0 1 1 1 1 Maltose acetyltransferase DUF4484 PF14831.6 CCF51618.1 - 0.019 15.0 6.5 0.058 13.4 6.5 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4484) EOS1 PF12326.8 CCF51618.1 - 0.49 10.3 3.4 1.6 8.7 3.4 1.8 1 0 0 1 1 1 0 N-glycosylation protein Baculo_PP31 PF05311.11 CCF51618.1 - 5.2 6.5 12.3 17 4.8 12.3 1.8 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) Connexin PF00029.19 CCF51618.1 - 5.9 6.6 11.2 12 5.5 11.2 1.5 1 0 0 1 1 1 0 Connexin Paf1 PF03985.13 CCF51618.1 - 7.1 5.5 17.8 15 4.5 17.8 1.6 1 0 0 1 1 1 0 Paf1 PPL5 PF18168.1 CCF51618.1 - 7.2 5.8 11.3 16 4.7 11.3 1.5 1 0 0 1 1 1 0 Prim-pol family 5 Amino_oxidase PF01593.24 CCF51619.1 - 3.2e-51 175.0 0.1 4.1e-51 174.7 0.1 1.1 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 CCF51619.1 - 2.3e-12 47.0 1.4 7.7e-12 45.3 0.2 2.5 2 1 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 CCF51619.1 - 1.9e-08 33.8 0.2 3e-08 33.2 0.2 1.3 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 CCF51619.1 - 5.2e-07 29.6 0.1 1.1e-06 28.5 0.0 1.5 2 0 0 2 2 2 1 FAD dependent oxidoreductase HI0933_like PF03486.14 CCF51619.1 - 5.3e-07 28.7 1.2 5e-05 22.2 0.1 2.2 2 0 0 2 2 2 2 HI0933-like protein Pyr_redox_2 PF07992.14 CCF51619.1 - 9.3e-07 28.4 0.1 1.6e-05 24.3 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 CCF51619.1 - 1.5e-06 27.9 0.1 2.3e-06 27.2 0.1 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.17 CCF51619.1 - 7.5e-06 25.4 0.2 1.3e-05 24.6 0.2 1.3 1 0 0 1 1 1 1 Thi4 family Pyr_redox PF00070.27 CCF51619.1 - 2.4e-05 24.8 0.2 0.00031 21.2 0.0 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 CCF51619.1 - 5.6e-05 22.5 1.0 0.00014 21.2 0.2 1.8 2 0 0 2 2 2 1 FAD binding domain GIDA PF01134.22 CCF51619.1 - 0.00014 21.1 0.0 0.00026 20.2 0.0 1.4 1 0 0 1 1 1 1 Glucose inhibited division protein A Lycopene_cycl PF05834.12 CCF51619.1 - 0.00078 18.6 0.7 0.0012 18.0 0.1 1.6 2 0 0 2 2 2 1 Lycopene cyclase protein Pyr_redox_3 PF13738.6 CCF51619.1 - 0.0011 18.3 0.2 0.011 15.0 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 CCF51619.1 - 0.017 14.4 0.2 0.033 13.5 0.2 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Gti1_Pac2 PF09729.9 CCF51621.1 - 2.5e-61 206.9 1.0 8e-60 202.0 0.0 2.7 2 1 0 2 2 2 1 Gti1/Pac2 family HSA PF07529.13 CCF51622.1 - 7.7e-13 48.6 2.8 7.7e-13 48.6 2.8 4.8 5 0 0 5 5 5 1 HSA Myb_DNA-bind_6 PF13921.6 CCF51622.1 - 4.4e-06 26.9 0.2 4.4e-06 26.9 0.2 2.6 3 0 0 3 3 3 1 Myb-like DNA-binding domain SANT_DAMP1_like PF16282.5 CCF51622.1 - 0.0012 19.0 0.2 0.0035 17.5 0.2 1.7 1 0 0 1 1 1 1 SANT/Myb-like domain of DAMP1 Myb_DNA-binding PF00249.31 CCF51622.1 - 0.0059 16.8 0.0 0.013 15.7 0.0 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain Exo_endo_phos PF03372.23 CCF51623.1 - 2e-15 57.0 0.0 1.6e-14 54.0 0.0 2.1 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Rsm1 PF08600.10 CCF51623.1 - 0.094 12.9 0.0 0.43 10.7 0.0 2.1 2 0 0 2 2 2 0 Rsm1-like Syja_N PF02383.18 CCF51624.1 - 5e-79 265.9 0.0 7e-79 265.4 0.0 1.2 1 0 0 1 1 1 1 SacI homology domain SF3A2 PF16835.5 CCF51625.1 - 3.9e-34 116.9 0.0 5.9e-34 116.3 0.0 1.3 1 0 0 1 1 1 1 Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11) zf-met PF12874.7 CCF51625.1 - 1e-06 28.9 1.2 2.2e-06 27.9 0.7 1.8 2 0 0 2 2 2 1 Zinc-finger of C2H2 type PRP4 PF08799.11 CCF51625.1 - 0.02 14.5 0.6 0.039 13.5 0.6 1.5 1 0 0 1 1 1 0 pre-mRNA processing factor 4 (PRP4) like CactinC_cactus PF09732.9 CCF51625.1 - 0.037 13.9 0.0 0.061 13.3 0.0 1.3 1 0 0 1 1 1 0 Cactus-binding C-terminus of cactin protein Proteasome PF00227.26 CCF51626.1 - 1e-28 100.2 0.0 1.2e-28 99.9 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Glycos_trans_3N PF02885.17 CCF51626.1 - 0.025 14.4 0.0 0.64 9.9 0.0 2.3 2 0 0 2 2 2 0 Glycosyl transferase family, helical bundle domain Phyto_Pns9_10 PF05878.11 CCF51626.1 - 0.049 12.8 0.0 0.073 12.2 0.0 1.2 1 0 0 1 1 1 0 Phytoreovirus nonstructural protein Pns9/Pns10 Cu-oxidase_3 PF07732.15 CCF51628.1 - 4.4e-43 146.1 0.0 4.4e-43 146.1 0.0 3.7 4 0 0 4 4 4 1 Multicopper oxidase Cu-oxidase PF00394.22 CCF51628.1 - 4.3e-30 104.9 0.0 2.4e-29 102.5 0.0 2.2 3 0 0 3 3 3 1 Multicopper oxidase Cu-oxidase_2 PF07731.14 CCF51628.1 - 3.9e-29 101.1 1.2 3.4e-28 98.1 1.0 4.8 5 0 0 5 5 5 4 Multicopper oxidase Zip PF02535.22 CCF51628.1 - 4.2 6.5 14.4 6.4 5.9 14.4 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter LAG1-DNAbind PF09271.11 CCF51629.1 - 6.9e-37 127.4 0.0 6.9e-37 127.4 0.0 3.0 4 0 0 4 4 4 1 LAG1, DNA binding BTD PF09270.10 CCF51629.1 - 3.2e-13 50.2 0.0 6.8e-13 49.1 0.0 1.5 1 0 0 1 1 1 1 Beta-trefoil DNA-binding domain DUF3545 PF12065.8 CCF51629.1 - 0.15 12.1 0.1 0.35 10.9 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3545) Rad60-SLD PF11976.8 CCF51630.1 - 7.1e-26 89.8 0.2 8.1e-26 89.7 0.2 1.0 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 CCF51630.1 - 4.2e-15 55.2 0.0 4.7e-15 55.1 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin family Nuc_recep-AF1 PF11825.8 CCF51631.1 - 0.16 12.0 1.4 0.18 11.9 1.4 1.2 1 0 0 1 1 1 0 Nuclear/hormone receptor activator site AF-1 Pardaxin PF07425.11 CCF51631.1 - 0.58 9.8 12.5 0.35 10.5 1.5 3.1 1 1 2 3 3 3 0 Pardaxin TPR_1 PF00515.28 CCF51632.1 - 6e-38 127.1 21.2 1.1e-05 25.0 0.0 10.8 11 0 0 11 11 11 8 Tetratricopeptide repeat TPR_2 PF07719.17 CCF51632.1 - 1.4e-37 124.7 20.1 0.00013 21.8 0.9 11.4 11 0 0 11 11 11 7 Tetratricopeptide repeat TPR_8 PF13181.6 CCF51632.1 - 7.8e-25 85.0 17.2 0.00013 21.9 0.0 9.8 10 0 0 10 10 10 6 Tetratricopeptide repeat TPR_16 PF13432.6 CCF51632.1 - 1.9e-19 70.0 18.9 3.4e-06 27.6 0.0 7.4 5 3 4 9 9 8 7 Tetratricopeptide repeat TPR_17 PF13431.6 CCF51632.1 - 4.9e-18 64.1 8.9 0.0067 16.7 0.0 10.0 9 1 0 9 9 9 3 Tetratricopeptide repeat TPR_11 PF13414.6 CCF51632.1 - 3.2e-17 61.9 14.1 1.3e-05 24.8 0.0 8.2 6 1 2 8 8 8 5 TPR repeat TPR_14 PF13428.6 CCF51632.1 - 2.2e-16 59.1 18.9 0.0042 17.8 0.0 11.4 7 4 6 13 13 11 6 Tetratricopeptide repeat TPR_12 PF13424.6 CCF51632.1 - 1e-14 54.6 23.0 0.01 16.1 0.3 8.3 5 3 3 8 8 7 6 Tetratricopeptide repeat TPR_9 PF13371.6 CCF51632.1 - 3.5e-11 43.1 0.5 3.9e-06 26.9 0.0 5.4 3 2 1 5 5 5 2 Tetratricopeptide repeat TPR_7 PF13176.6 CCF51632.1 - 5.4e-11 41.7 6.4 0.041 13.9 0.1 7.6 7 0 0 7 7 7 3 Tetratricopeptide repeat ANAPC3 PF12895.7 CCF51632.1 - 3.8e-09 36.6 13.4 0.045 14.0 0.4 5.8 2 1 4 6 6 6 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 CCF51632.1 - 4.3e-08 33.5 27.5 0.00047 20.6 1.6 7.3 4 3 3 8 8 7 4 Tetratricopeptide repeat TPR_10 PF13374.6 CCF51632.1 - 0.00019 21.2 11.7 1.3 9.0 0.1 7.0 8 0 0 8 8 8 2 Tetratricopeptide repeat SpoIIIAH PF12685.7 CCF51632.1 - 0.00092 19.1 6.8 0.00092 19.1 6.8 2.7 2 1 1 3 3 2 1 SpoIIIAH-like protein SHNi-TPR PF10516.9 CCF51632.1 - 0.21 11.0 8.3 8.2 6.0 0.5 5.1 6 0 0 6 6 6 0 SHNi-TPR DUF883 PF05957.13 CCF51632.1 - 0.75 10.4 7.5 1 10.0 3.6 3.2 3 0 0 3 3 2 0 Bacterial protein of unknown function (DUF883) ANAPC5 PF12862.7 CCF51632.1 - 2.5 8.2 10.0 9.1 6.4 0.1 4.4 3 2 0 3 3 3 0 Anaphase-promoting complex subunit 5 PALP PF00291.25 CCF51633.1 - 5.2e-52 177.1 2.7 1.7e-28 99.9 0.9 2.1 2 0 0 2 2 2 2 Pyridoxal-phosphate dependent enzyme Complex1_LYR_2 PF13233.6 CCF51634.1 - 2.7e-15 56.9 0.8 5.6e-15 55.9 0.8 1.6 1 1 0 1 1 1 1 Complex1_LYR-like COMPASS-Shg1 PF05205.12 CCF51635.1 - 2.2e-05 25.1 0.0 9.7e-05 23.0 0.0 2.0 2 0 0 2 2 2 1 COMPASS (Complex proteins associated with Set1p) component shg1 DUF4611 PF15387.6 CCF51635.1 - 0.0051 17.0 5.2 0.01 16.0 5.2 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4611) GCIP PF13324.6 CCF51635.1 - 0.033 13.8 3.8 0.05 13.2 3.8 1.2 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting PBP1_TM PF14812.6 CCF51635.1 - 0.19 12.1 4.4 0.33 11.3 4.4 1.3 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal PAC1 PF16094.5 CCF51635.1 - 0.54 9.4 3.8 0.73 8.9 3.8 1.2 1 0 0 1 1 1 0 Proteasome assembly chaperone 4 NOA36 PF06524.12 CCF51635.1 - 1.4 8.1 5.5 2 7.6 5.5 1.1 1 0 0 1 1 1 0 NOA36 protein S-antigen PF05756.11 CCF51635.1 - 4.1 7.8 5.2 7.1 7.1 5.2 1.3 1 0 0 1 1 1 0 S-antigen protein CENP-B_dimeris PF09026.10 CCF51635.1 - 4.2 7.8 9.6 11 6.4 9.6 1.7 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DNA_pol_phi PF04931.13 CCF51635.1 - 9.6 4.2 8.2 14 3.6 8.2 1.2 1 0 0 1 1 1 0 DNA polymerase phi DUF2347 PF09804.9 CCF51636.1 - 7.4e-44 150.4 0.0 1.2e-41 143.2 0.0 2.4 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2347) Avl9 PF09794.9 CCF51636.1 - 0.0069 15.1 0.0 0.012 14.3 0.0 1.3 1 0 0 1 1 1 1 Transport protein Avl9 Afi1 PF07792.12 CCF51636.1 - 0.0091 16.5 1.9 0.094 13.2 0.0 3.0 3 0 0 3 3 3 1 Docking domain of Afi1 for Arf3 in vesicle trafficking DraK_HK_N PF18092.1 CCF51636.1 - 0.066 13.6 3.4 1.5 9.3 0.9 2.8 2 0 0 2 2 2 0 DraK Histidine Kinase N-terminal domain Homez PF11569.8 CCF51636.1 - 0.12 11.8 0.0 0.32 10.5 0.0 1.6 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez Mito_carr PF00153.27 CCF51637.1 - 1.3e-62 207.7 4.1 2.3e-22 78.7 0.2 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein COX16 PF14138.6 CCF51638.1 - 5.4e-29 100.5 0.1 9.9e-29 99.7 0.1 1.5 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein COX16 Evr1_Alr PF04777.13 CCF51638.1 - 2.6e-26 92.0 0.1 6.2e-26 90.8 0.0 1.7 2 0 0 2 2 2 1 Erv1 / Alr family DUF2630 PF10944.8 CCF51638.1 - 0.97 9.9 4.6 0.61 10.6 2.3 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2630) PLA2_B PF01735.18 CCF51639.1 - 1.4e-15 56.7 0.0 3.2e-12 45.6 0.0 3.0 3 0 0 3 3 3 3 Lysophospholipase catalytic domain ACPS PF01648.20 CCF51639.1 - 1.7e-14 53.9 0.2 5.7e-14 52.2 0.2 2.0 1 1 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily DEAD PF00270.29 CCF51641.1 - 1.9e-13 50.6 0.0 3.4e-13 49.7 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CCF51641.1 - 0.00099 19.4 0.0 0.0032 17.8 0.0 1.9 1 1 0 1 1 1 1 Helicase conserved C-terminal domain Longin PF13774.6 CCF51642.1 - 8.7e-26 89.8 0.1 1.3e-25 89.2 0.1 1.3 1 0 0 1 1 1 1 Regulated-SNARE-like domain Synaptobrevin PF00957.21 CCF51642.1 - 5e-15 55.1 0.1 1.2e-14 53.8 0.1 1.7 1 1 0 1 1 1 1 Synaptobrevin SLM4 PF16818.5 CCF51642.1 - 0.018 15.0 0.8 2.3 8.2 0.0 2.2 1 1 1 2 2 2 0 Protein SLM4 DUF1664 PF07889.12 CCF51642.1 - 0.08 13.0 1.6 0.11 12.5 0.4 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) BTB_2 PF02214.22 CCF51643.1 - 0.00042 20.6 0.0 0.049 14.0 0.0 2.5 2 0 0 2 2 2 2 BTB/POZ domain Ribosomal_S10 PF00338.22 CCF51644.1 - 1.2e-22 79.9 0.0 2.8e-22 78.8 0.0 1.6 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e DUF1708 PF08101.11 CCF51647.1 - 7.2e-21 74.8 0.1 5.5e-18 65.3 0.1 2.4 1 1 0 1 1 1 1 Domain of unknown function (DUF1708) RhoGAP PF00620.27 CCF51647.1 - 2.1e-05 24.4 0.0 0.00019 21.3 0.0 2.2 1 1 0 1 1 1 1 RhoGAP domain FA_hydroxylase PF04116.13 CCF51648.1 - 1e-23 84.1 18.4 1e-23 84.1 18.4 1.7 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily Bromodomain PF00439.25 CCF51649.1 - 2.7e-20 72.2 0.1 4.5e-20 71.5 0.1 1.3 1 0 0 1 1 1 1 Bromodomain Nop14 PF04147.12 CCF51649.1 - 4.4 5.4 28.3 3.8 5.6 2.8 2.4 2 0 0 2 2 2 0 Nop14-like family WD40 PF00400.32 CCF51650.1 - 9.5e-43 143.4 13.6 3.4e-08 34.0 0.4 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat Nup160 PF11715.8 CCF51650.1 - 0.0018 17.0 0.5 2.1 6.9 0.0 3.3 2 1 1 3 3 3 2 Nucleoporin Nup120/160 WD40_like PF17005.5 CCF51650.1 - 0.14 11.5 0.0 0.35 10.2 0.0 1.7 1 0 0 1 1 1 0 WD40-like domain TFIIS_M PF07500.14 CCF51651.1 - 5.2e-30 104.2 2.3 5.2e-30 104.2 2.3 2.7 4 0 0 4 4 4 1 Transcription factor S-II (TFIIS), central domain TFIIS_C PF01096.18 CCF51651.1 - 7.7e-19 67.3 8.9 1.3e-18 66.6 8.9 1.4 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS) Med26 PF08711.11 CCF51651.1 - 1e-11 44.7 0.2 2.8e-11 43.3 0.2 1.8 1 0 0 1 1 1 1 TFIIS helical bundle-like domain HTH_22 PF13309.6 CCF51651.1 - 0.065 13.3 0.1 0.16 12.1 0.1 1.7 1 0 0 1 1 1 0 HTH domain zinc_ribbon_4 PF13717.6 CCF51651.1 - 0.22 11.5 3.9 0.58 10.1 0.4 2.8 2 0 0 2 2 2 0 zinc-ribbon domain zinc_ribbon_12 PF11331.8 CCF51651.1 - 0.84 9.5 2.6 31 4.5 0.2 2.7 2 0 0 2 2 2 0 Probable zinc-ribbon domain zf-DNL PF05180.12 CCF51651.1 - 1.5 8.9 4.6 1.1 9.2 2.5 1.9 2 0 0 2 2 2 0 DNL zinc finger Ammonium_transp PF00909.21 CCF51652.1 - 3.1e-113 378.5 33.4 3.5e-113 378.3 33.4 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family MRP-S28 PF10213.9 CCF51653.1 - 1.9e-37 128.5 0.0 3.5e-37 127.7 0.0 1.4 1 0 0 1 1 1 1 Mitochondrial ribosomal subunit protein FliD_N PF02465.18 CCF51653.1 - 1.6 9.5 5.5 2.6 8.8 4.8 1.7 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus AAA_33 PF13671.6 CCF51654.1 - 4.8e-11 43.0 0.2 1.2e-08 35.3 0.2 2.3 1 1 0 1 1 1 1 AAA domain tRNA_lig_kinase PF08303.11 CCF51654.1 - 2.4e-08 34.3 0.0 3.6e-08 33.7 0.0 1.2 1 0 0 1 1 1 1 tRNA ligase kinase domain AAA_22 PF13401.6 CCF51654.1 - 0.00026 21.3 0.0 0.00046 20.5 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 CCF51654.1 - 0.0016 19.0 0.3 0.0075 16.8 0.1 2.2 2 1 0 2 2 2 1 AAA domain T2SSE PF00437.20 CCF51654.1 - 0.0079 15.3 0.0 0.018 14.1 0.0 1.5 2 0 0 2 2 2 1 Type II/IV secretion system protein DUF4901 PF16244.5 CCF51654.1 - 0.014 14.8 0.1 0.021 14.2 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4901) dNK PF01712.19 CCF51654.1 - 0.02 14.8 0.0 0.061 13.2 0.0 1.7 2 0 0 2 2 2 0 Deoxynucleoside kinase AAA_16 PF13191.6 CCF51654.1 - 0.021 15.2 0.1 0.036 14.5 0.1 1.4 1 0 0 1 1 1 0 AAA ATPase domain TsaE PF02367.17 CCF51654.1 - 0.065 13.2 0.0 0.13 12.3 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE CPT PF07931.12 CCF51654.1 - 0.16 11.8 0.0 0.75 9.6 0.0 2.0 1 1 1 2 2 2 0 Chloramphenicol phosphotransferase-like protein Homeobox_KN PF05920.11 CCF51654.1 - 0.23 11.4 2.6 0.41 10.6 0.6 2.3 2 0 0 2 2 2 0 Homeobox KN domain SIR2 PF02146.17 CCF51655.1 - 6.8e-52 176.0 0.0 9.4e-52 175.5 0.0 1.2 1 0 0 1 1 1 1 Sir2 family adh_short PF00106.25 CCF51656.1 - 6.6e-48 162.8 0.7 8.2e-48 162.5 0.7 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF51656.1 - 8e-34 117.2 0.8 1.1e-33 116.8 0.8 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF51656.1 - 2.4e-10 40.6 0.1 3.4e-10 40.1 0.1 1.2 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 CCF51656.1 - 3e-05 23.6 0.0 0.00017 21.1 0.0 1.9 1 1 0 1 1 1 1 Fungal family of unknown function (DUF1776) NAD_binding_10 PF13460.6 CCF51656.1 - 0.00067 19.6 0.1 0.0011 18.9 0.0 1.4 1 1 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 CCF51656.1 - 0.0017 17.8 0.1 0.0068 15.9 0.1 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family DUF959 PF06121.14 CCF51656.1 - 0.081 13.2 0.1 0.14 12.4 0.1 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF959) Lactamase_B_2 PF12706.7 CCF51657.1 - 8.4e-28 97.3 0.0 1.5e-27 96.4 0.0 1.4 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 CCF51657.1 - 1.7e-05 24.7 0.0 0.00092 19.1 0.0 2.6 2 0 0 2 2 2 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 CCF51657.1 - 0.51 10.3 5.5 1.3 9.0 5.5 1.6 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily A_deamin PF02137.18 CCF51658.1 - 5e-43 147.8 0.0 3.9e-41 141.6 0.0 2.2 2 0 0 2 2 2 2 Adenosine-deaminase (editase) domain SNAD4 PF18750.1 CCF51658.1 - 0.036 14.2 0.0 0.076 13.1 0.0 1.5 1 0 0 1 1 1 0 Secreted Novel AID/APOBEC-like Deaminase 4 POTRA_TamA_1 PF17243.2 CCF51658.1 - 0.13 12.4 0.4 1 9.5 0.0 2.6 2 0 0 2 2 2 0 POTRA domain TamA domain 1 APOBEC4_like PF18774.1 CCF51658.1 - 0.2 11.6 0.0 0.41 10.6 0.0 1.4 1 0 0 1 1 1 0 APOBEC4-like -AID/APOBEC-deaminase F-box-like PF12937.7 CCF51660.1 - 0.002 18.0 0.0 0.0066 16.3 0.0 2.0 1 1 0 1 1 1 1 F-box-like Rubella_E2 PF05749.11 CCF51660.1 - 0.0032 17.0 2.0 0.017 14.6 3.1 1.6 2 0 0 2 2 2 1 Rubella membrane glycoprotein E2 DUF2057 PF09829.9 CCF51660.1 - 0.98 9.6 2.9 2 8.6 2.9 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2057) Peptidase_M20 PF01546.28 CCF51661.1 - 8.5e-30 104.0 0.0 1.3e-29 103.4 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 CCF51661.1 - 8e-13 48.3 0.0 1.6e-12 47.3 0.0 1.5 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 CCF51661.1 - 0.013 15.2 0.0 0.037 13.7 0.0 1.7 1 1 0 1 1 1 0 Peptidase family M28 DER1 PF04511.15 CCF51662.1 - 2.5e-37 128.7 0.2 3e-37 128.4 0.2 1.1 1 0 0 1 1 1 1 Der1-like family zf-CCHC PF00098.23 CCF51663.1 - 2e-13 49.7 20.9 6.8e-05 22.8 1.2 4.3 4 0 0 4 4 4 4 Zinc knuckle zf-CCHC_2 PF13696.6 CCF51663.1 - 3.5e-05 23.5 21.8 0.26 11.2 3.9 4.2 4 0 0 4 4 4 4 Zinc knuckle zf-CCHC_6 PF15288.6 CCF51663.1 - 0.026 14.4 0.6 0.026 14.4 0.6 3.5 4 0 0 4 4 4 0 Zinc knuckle zf-CCHC_4 PF14392.6 CCF51663.1 - 0.17 11.6 21.5 0.13 12.1 0.5 4.3 4 0 0 4 4 4 0 Zinc knuckle ORC6 PF05460.13 CCF51663.1 - 1.7 7.8 26.0 4 6.6 26.0 1.6 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) Methyltransf_25 PF13649.6 CCF51664.1 - 6.3e-11 42.8 0.0 1.3e-10 41.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 CCF51664.1 - 5.3e-10 39.2 0.0 7.3e-10 38.7 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_31 PF13847.6 CCF51664.1 - 1e-09 38.4 0.1 1.5e-09 37.9 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF51664.1 - 8.3e-08 32.8 0.0 2.1e-07 31.5 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCF51664.1 - 1.9e-07 31.1 0.0 3.1e-07 30.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_9 PF08003.11 CCF51664.1 - 8.7e-06 24.9 0.0 1.2e-05 24.4 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) Methyltransf_12 PF08242.12 CCF51664.1 - 9e-06 26.4 0.0 2e-05 25.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 CCF51664.1 - 0.00058 19.2 0.0 0.00078 18.8 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase MTS PF05175.14 CCF51664.1 - 0.00097 18.7 0.4 0.0021 17.6 0.3 1.6 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_18 PF12847.7 CCF51664.1 - 0.027 14.4 0.1 0.046 13.7 0.1 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_16 PF10294.9 CCF51664.1 - 0.057 13.2 0.1 0.082 12.6 0.1 1.3 1 0 0 1 1 1 0 Lysine methyltransferase DOT1 PF08123.13 CCF51664.1 - 0.096 12.2 0.0 0.16 11.5 0.0 1.4 1 0 0 1 1 1 0 Histone methylation protein DOT1 PCMT PF01135.19 CCF51664.1 - 0.13 12.0 0.0 0.21 11.3 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) zf-CCHC PF00098.23 CCF51665.1 - 0.00016 21.6 1.4 0.00035 20.5 1.4 1.6 1 0 0 1 1 1 1 Zinc knuckle V-SNARE_C PF12352.8 CCF51666.1 - 9.4e-16 57.9 1.7 2.3e-15 56.6 1.7 1.7 1 0 0 1 1 1 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.13 CCF51666.1 - 6.1e-07 29.3 0.2 1.5e-06 28.0 0.0 1.6 2 0 0 2 2 2 1 Sec20 DUF3958 PF13125.6 CCF51666.1 - 0.0074 16.5 2.1 0.75 10.0 0.2 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF3958) Vac7 PF12751.7 CCF51666.1 - 0.042 13.3 2.4 0.048 13.1 2.4 1.1 1 0 0 1 1 1 0 Vacuolar segregation subunit 7 Mito_fiss_reg PF05308.11 CCF51666.1 - 0.099 12.7 0.3 0.13 12.3 0.3 1.2 1 0 0 1 1 1 0 Mitochondrial fission regulator Oxidored_q6 PF01058.22 CCF51667.1 - 2.9e-21 75.7 0.1 4.3e-21 75.1 0.1 1.2 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase, 20 Kd subunit Pkinase PF00069.25 CCF51669.1 - 3.3e-45 154.5 0.0 5.4e-44 150.5 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF51669.1 - 3.7e-18 65.7 0.0 1.3e-17 64.0 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 CCF51669.1 - 0.00098 19.1 0.2 0.0017 18.3 0.2 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 CCF51669.1 - 0.0052 16.2 0.1 0.0083 15.5 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 CCF51669.1 - 0.0078 15.6 0.0 0.013 14.9 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 CCF51669.1 - 0.026 13.3 0.0 0.045 12.5 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase Haspin_kinase PF12330.8 CCF51669.1 - 0.56 9.1 4.6 0.72 8.7 0.0 2.9 3 0 0 3 3 3 0 Haspin like kinase domain WD40 PF00400.32 CCF51670.1 - 4.7e-10 39.9 12.4 0.00088 20.0 0.1 6.5 6 1 1 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF51670.1 - 8.1e-08 32.5 0.2 0.0016 18.7 0.0 4.1 1 1 4 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain DPPIV_N PF00930.21 CCF51670.1 - 0.021 13.6 0.5 0.43 9.3 0.3 2.5 2 1 0 2 2 2 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region DAP3 PF10236.9 CCF51671.1 - 7e-74 248.8 2.1 8.4e-74 248.5 2.1 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal death-associated protein 3 AAA_16 PF13191.6 CCF51671.1 - 3.2e-07 30.9 0.9 6.6e-07 29.9 0.3 1.8 1 1 1 2 2 2 1 AAA ATPase domain ATPase_2 PF01637.18 CCF51671.1 - 0.0086 16.0 0.1 0.12 12.2 0.0 2.4 2 1 0 2 2 2 1 ATPase domain predominantly from Archaea AAA_22 PF13401.6 CCF51671.1 - 0.025 14.8 1.1 0.31 11.3 0.2 2.6 2 1 0 2 2 2 0 AAA domain DUF815 PF05673.13 CCF51671.1 - 0.037 13.2 0.2 0.22 10.7 0.0 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF815) NACHT PF05729.12 CCF51671.1 - 0.077 12.9 0.2 0.52 10.2 0.0 2.3 2 0 0 2 2 2 0 NACHT domain AAA_14 PF13173.6 CCF51671.1 - 0.079 13.0 0.0 0.25 11.4 0.0 1.9 2 0 0 2 2 2 0 AAA domain Cor1 PF04803.12 CCF51672.1 - 0.01 16.1 1.6 0.01 16.1 1.6 1.8 2 0 0 2 2 2 0 Cor1/Xlr/Xmr conserved region SKA2 PF16740.5 CCF51672.1 - 0.25 11.2 5.8 0.13 12.1 2.4 2.4 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 2 SHE3 PF17078.5 CCF51672.1 - 0.28 10.9 13.9 0.027 14.2 6.2 2.1 1 1 0 2 2 2 0 SWI5-dependent HO expression protein 3 KH_1 PF00013.29 CCF51673.1 - 8.5e-45 150.4 9.9 5.1e-16 58.2 0.5 3.3 3 0 0 3 3 3 3 KH domain KH_2 PF07650.17 CCF51673.1 - 4.2e-15 55.3 6.5 1.4e-05 24.8 0.2 3.3 3 0 0 3 3 3 3 KH domain KH_4 PF13083.6 CCF51673.1 - 3.5e-05 23.6 7.2 0.12 12.3 0.0 3.7 4 0 0 4 4 4 3 KH domain KH_5 PF13184.6 CCF51673.1 - 0.012 15.7 7.5 1.2 9.3 0.1 3.5 3 1 0 3 3 3 0 NusA-like KH domain Apt1 PF10351.9 CCF51673.1 - 2.1 7.1 6.9 2.9 6.6 6.9 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Macoilin PF09726.9 CCF51673.1 - 2.4 6.6 3.5 2.9 6.4 3.5 1.1 1 0 0 1 1 1 0 Macoilin family PBP1_TM PF14812.6 CCF51673.1 - 2.8 8.4 8.5 6.3 7.2 8.5 1.6 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal LSM PF01423.22 CCF51674.1 - 1.8e-13 50.0 0.0 2.2e-13 49.7 0.0 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 CCF51674.1 - 2.8e-05 24.2 0.0 3.8e-05 23.7 0.0 1.2 1 0 0 1 1 1 1 Ataxin 2 SM domain LSM14 PF12701.7 CCF51674.1 - 0.068 13.3 0.0 0.091 12.9 0.0 1.2 1 0 0 1 1 1 0 Scd6-like Sm domain PX PF00787.24 CCF51675.1 - 2.6e-25 88.6 0.0 4.7e-25 87.8 0.0 1.4 1 0 0 1 1 1 1 PX domain DUF641 PF04859.12 CCF51676.1 - 0.0016 18.8 3.5 0.0077 16.6 3.5 2.2 1 0 0 1 1 1 1 Plant protein of unknown function (DUF641) LCD1 PF09798.9 CCF51676.1 - 0.0068 15.0 2.9 1.7 7.1 0.0 2.4 2 0 0 2 2 2 2 DNA damage checkpoint protein NRIP1_repr_3 PF15689.5 CCF51676.1 - 0.015 15.5 0.1 0.093 13.0 0.1 2.4 1 0 0 1 1 1 0 Nuclear receptor-interacting protein 1 repression 3 BAMBI PF06211.12 CCF51676.1 - 0.031 14.5 0.0 0.078 13.2 0.0 1.6 1 0 0 1 1 1 0 BMP and activin membrane-bound inhibitor (BAMBI) N-terminal domain TMF_DNA_bd PF12329.8 CCF51676.1 - 0.31 11.1 14.7 0.026 14.5 8.5 2.5 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding V_ATPase_I PF01496.19 CCF51676.1 - 0.4 8.6 2.4 0.68 7.8 2.4 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF4407 PF14362.6 CCF51676.1 - 5.5 6.2 12.1 12 5.1 12.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) XPG_N PF00752.17 CCF51677.1 - 2.6e-35 120.9 0.0 6.2e-35 119.7 0.0 1.7 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.18 CCF51677.1 - 1.3e-30 105.6 0.3 3.8e-30 104.1 0.0 2.0 2 0 0 2 2 2 1 XPG I-region 5_3_exonuc PF01367.20 CCF51677.1 - 1.3e-07 32.1 0.0 4.5e-07 30.4 0.0 1.9 2 0 0 2 2 2 1 5'-3' exonuclease, C-terminal SAM fold HHH_5 PF14520.6 CCF51677.1 - 0.003 18.1 0.0 0.0093 16.6 0.0 1.8 1 0 0 1 1 1 1 Helix-hairpin-helix domain DNA_pol_lambd_f PF10391.9 CCF51677.1 - 0.041 13.7 0.1 0.2 11.5 0.0 2.2 3 0 0 3 3 3 0 Fingers domain of DNA polymerase lambda COQ7 PF03232.13 CCF51678.1 - 3.2e-65 219.1 0.2 4.8e-65 218.5 0.2 1.3 1 0 0 1 1 1 1 Ubiquinone biosynthesis protein COQ7 FAD_binding_3 PF01494.19 CCF51678.1 - 2.7e-13 49.9 15.2 8.5e-08 31.8 0.9 4.2 3 1 1 4 4 4 3 FAD binding domain SE PF08491.10 CCF51678.1 - 3.5e-05 23.0 0.1 0.00037 19.6 0.0 2.0 1 1 1 2 2 2 1 Squalene epoxidase DAO PF01266.24 CCF51678.1 - 9.9e-05 22.1 0.0 0.00021 21.0 0.0 1.6 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 CCF51678.1 - 0.013 15.5 0.0 0.025 14.6 0.0 1.5 1 0 0 1 1 1 0 FAD-NAD(P)-binding Trp_halogenase PF04820.14 CCF51678.1 - 0.031 13.1 0.0 0.37 9.6 0.0 2.3 2 0 0 2 2 2 0 Tryptophan halogenase Lycopene_cycl PF05834.12 CCF51678.1 - 0.084 11.9 0.7 2.1 7.3 0.0 2.8 3 0 0 3 3 3 0 Lycopene cyclase protein Pyr_redox_2 PF07992.14 CCF51678.1 - 0.12 11.5 0.0 0.22 10.7 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Ferritin PF00210.24 CCF51678.1 - 0.34 10.8 1.8 0.65 9.9 0.0 2.2 3 0 0 3 3 3 0 Ferritin-like domain Cyclin PF08613.11 CCF51679.1 - 1.2e-08 35.5 0.0 1.2e-08 35.5 0.0 2.5 3 1 0 3 3 3 1 Cyclin Cyclin_N PF00134.23 CCF51679.1 - 0.069 12.9 0.0 0.14 11.9 0.0 1.5 1 0 0 1 1 1 0 Cyclin, N-terminal domain Pkinase PF00069.25 CCF51680.1 - 3.6e-28 98.7 0.0 6e-27 94.7 0.0 2.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF51680.1 - 1.8e-14 53.7 0.0 5.8e-13 48.7 0.0 2.5 2 1 0 2 2 2 1 Protein tyrosine kinase APH PF01636.23 CCF51680.1 - 0.00011 22.2 0.0 0.00025 21.0 0.0 1.6 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 CCF51680.1 - 0.0054 16.1 0.0 0.0085 15.5 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 CCF51680.1 - 0.087 11.6 0.0 0.13 11.0 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase Kinase-like PF14531.6 CCF51680.1 - 0.19 11.0 0.1 0.49 9.7 0.1 1.6 1 1 0 1 1 1 0 Kinase-like GATase_4 PF13230.6 CCF51681.1 - 3.3e-18 65.6 0.0 1.3e-17 63.6 0.0 1.8 1 1 0 1 1 1 1 Glutamine amidotransferases class-II GATase_6 PF13522.6 CCF51681.1 - 1.3e-09 38.4 0.0 2.6e-09 37.4 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain Flavoprotein PF02441.19 CCF51682.1 - 2e-45 154.4 0.0 3.1e-45 153.8 0.0 1.3 1 0 0 1 1 1 1 Flavoprotein VPS9 PF02204.18 CCF51682.1 - 7.5e-27 93.6 0.0 1.5e-26 92.7 0.0 1.5 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain RF-1 PF00472.20 CCF51682.1 - 0.11 12.5 0.1 0.34 10.9 0.0 1.8 2 0 0 2 2 2 0 RF-1 domain FAD_binding_7 PF03441.14 CCF51683.1 - 6.6e-50 169.4 4.3 9.7e-50 168.9 4.3 1.2 1 0 0 1 1 1 1 FAD binding domain of DNA photolyase DNA_photolyase PF00875.18 CCF51683.1 - 3e-22 79.4 0.0 9.2e-22 77.8 0.0 1.7 1 1 0 1 1 1 1 DNA photolyase HSP70 PF00012.20 CCF51684.1 - 1.6e-160 535.2 0.2 2.5e-160 534.6 0.2 1.3 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 CCF51684.1 - 4.9e-09 35.5 0.0 1.4e-08 33.9 0.0 1.7 2 0 0 2 2 2 1 MreB/Mbl protein FGGY_C PF02782.16 CCF51684.1 - 0.022 14.5 0.0 0.059 13.1 0.0 1.7 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, C-terminal domain Aldedh PF00171.22 CCF51685.1 - 4.7e-13 48.5 3.5 1.7e-12 46.6 0.0 2.6 3 0 0 3 3 3 2 Aldehyde dehydrogenase family Ribosomal_L34 PF00468.17 CCF51686.1 - 3.3e-16 59.0 8.4 5.3e-16 58.3 8.4 1.4 1 0 0 1 1 1 1 Ribosomal protein L34 ATP-synt_C PF00137.21 CCF51687.1 - 1.7e-27 95.5 34.7 7.1e-16 58.3 14.0 2.8 3 0 0 3 3 3 2 ATP synthase subunit C Oxidored_q2 PF00420.24 CCF51687.1 - 6.8 6.4 10.1 1.9 8.1 4.6 2.9 2 1 1 3 3 3 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L Insulin_TMD PF17870.1 CCF51687.1 - 6.9 6.8 6.8 1.7 8.8 0.7 2.5 2 0 0 2 2 2 0 Insulin receptor trans-membrane segment Dus PF01207.17 CCF51689.1 - 4.7e-47 160.6 0.0 7.4e-45 153.4 0.0 2.4 1 1 0 1 1 1 1 Dihydrouridine synthase (Dus) zf-CCCH_4 PF18044.1 CCF51689.1 - 0.013 15.3 8.0 0.036 13.9 1.1 2.7 2 1 0 2 2 2 0 CCCH-type zinc finger DUF155 PF02582.14 CCF51690.1 - 1e-50 172.3 0.0 1.9e-50 171.4 0.0 1.5 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 NOA36 PF06524.12 CCF51690.1 - 7.4 5.8 13.2 14 4.9 13.2 1.4 1 0 0 1 1 1 0 NOA36 protein FoP_duplication PF13865.6 CCF51691.1 - 5.9 7.5 10.2 10 6.8 10.2 1.4 1 0 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 SQHop_cyclase_C PF13243.6 CCF51692.1 - 3e-54 184.3 3.4 2.6e-50 171.4 2.0 2.2 2 0 0 2 2 2 2 Squalene-hopene cyclase C-terminal domain SQHop_cyclase_N PF13249.6 CCF51692.1 - 3.9e-51 173.9 6.3 6.3e-42 143.6 0.5 4.1 3 1 1 4 4 4 3 Squalene-hopene cyclase N-terminal domain Prenyltrans PF00432.21 CCF51692.1 - 1.2e-30 104.9 11.2 1.7e-09 37.3 0.0 7.0 7 0 0 7 7 7 3 Prenyltransferase and squalene oxidase repeat TED_complement PF07678.14 CCF51692.1 - 1.2e-06 27.8 2.9 4.1e-06 26.0 0.7 2.6 2 1 1 3 3 3 2 A-macroglobulin TED domain Pec_lyase PF09492.10 CCF51692.1 - 0.00019 20.9 1.4 2.8 7.2 0.0 4.2 3 1 2 5 5 5 2 Pectic acid lyase Cobalamin_bind PF01122.19 CCF51692.1 - 0.15 11.0 0.0 0.27 10.1 0.0 1.3 1 0 0 1 1 1 0 Eukaryotic cobalamin-binding protein DUF1242 PF06842.12 CCF51693.1 - 1.4e-18 66.4 0.8 1.8e-18 66.0 0.8 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1242) GST_N PF02798.20 CCF51694.1 - 7.6e-13 48.6 0.0 1.9e-12 47.4 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 CCF51694.1 - 1.2e-10 41.6 0.0 2.8e-10 40.5 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 CCF51694.1 - 2.3e-09 37.3 0.5 7.3e-09 35.7 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 CCF51694.1 - 5.8e-09 35.9 0.1 2.6e-08 33.7 0.0 2.1 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 CCF51694.1 - 4.7e-08 33.2 0.0 1.3e-07 31.8 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 CCF51694.1 - 2.2e-06 27.8 0.5 5e-06 26.6 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain Thioredoxin_8 PF13905.6 CCF51694.1 - 0.069 13.5 0.0 0.14 12.5 0.0 1.6 1 0 0 1 1 1 0 Thioredoxin-like Sua5_yciO_yrdC PF01300.18 CCF51695.1 - 1.1e-47 161.9 0.0 1.1e-46 158.6 0.0 2.2 1 1 0 1 1 1 1 Telomere recombination SUA5 PF03481.13 CCF51695.1 - 1.1e-29 103.8 0.0 2.1e-29 102.8 0.0 1.5 1 1 0 1 1 1 1 Putative GTP-binding controlling metal-binding Ribonuc_L-PSP PF01042.21 CCF51695.1 - 0.13 12.3 0.0 0.31 11.1 0.0 1.6 1 0 0 1 1 1 0 Endoribonuclease L-PSP SARAF PF06682.12 CCF51696.1 - 0.00013 21.7 0.5 0.00018 21.3 0.5 1.2 1 0 0 1 1 1 1 SOCE-associated regulatory factor of calcium homoeostasis COX14 PF14880.6 CCF51696.1 - 0.0059 16.4 0.1 0.014 15.2 0.1 1.6 1 0 0 1 1 1 1 Cytochrome oxidase c assembly DUF456 PF04306.13 CCF51696.1 - 0.012 15.9 0.2 0.02 15.2 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF456) EphA2_TM PF14575.6 CCF51696.1 - 0.015 16.2 1.6 0.077 13.9 1.6 2.1 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain TMEM154 PF15102.6 CCF51696.1 - 0.018 14.9 3.8 0.075 12.9 0.0 2.2 2 0 0 2 2 2 0 TMEM154 protein family DUF4064 PF13273.6 CCF51696.1 - 0.046 14.0 0.0 0.096 13.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4064) GRP PF07172.11 CCF51696.1 - 0.067 13.9 7.1 0.69 10.6 0.0 2.7 3 0 0 3 3 3 0 Glycine rich protein family SCF PF02404.15 CCF51696.1 - 0.14 11.5 0.0 0.21 10.9 0.0 1.2 1 0 0 1 1 1 0 Stem cell factor Syndecan PF01034.20 CCF51696.1 - 0.17 11.8 1.7 0.36 10.8 1.7 1.5 1 0 0 1 1 1 0 Syndecan domain YajC PF02699.15 CCF51696.1 - 1.1 9.2 0.0 1.1 9.2 0.0 2.2 2 0 0 2 2 2 0 Preprotein translocase subunit Pkinase PF00069.25 CCF51697.1 - 1.9e-70 237.2 0.0 2.7e-70 236.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF51697.1 - 9.3e-57 192.3 0.0 1.4e-56 191.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase CH PF00307.31 CCF51697.1 - 1.2e-10 41.5 0.0 2.5e-10 40.5 0.0 1.4 1 0 0 1 1 1 1 Calponin homology (CH) domain C1_1 PF00130.22 CCF51697.1 - 1.4e-06 28.0 8.8 2.8e-06 27.1 8.8 1.5 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) CDC24 PF06395.11 CCF51697.1 - 0.0015 18.7 0.0 0.0052 17.0 0.0 1.8 2 0 0 2 2 2 1 CDC24 Calponin CAMSAP_CH PF11971.8 CCF51697.1 - 0.0027 17.5 0.0 0.011 15.6 0.0 2.0 2 0 0 2 2 2 1 CAMSAP CH domain Kinase-like PF14531.6 CCF51697.1 - 0.0042 16.5 0.0 0.01 15.2 0.0 1.5 2 0 0 2 2 2 1 Kinase-like RIO1 PF01163.22 CCF51697.1 - 0.0055 16.3 0.0 0.011 15.3 0.0 1.4 1 0 0 1 1 1 1 RIO1 family Pkinase_fungal PF17667.1 CCF51697.1 - 0.0096 14.7 0.6 0.031 13.1 0.0 2.0 2 0 0 2 2 2 1 Fungal protein kinase Seadorna_VP7 PF07387.11 CCF51697.1 - 0.011 14.8 0.2 0.018 14.1 0.2 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 C1_2 PF03107.16 CCF51697.1 - 0.16 12.3 3.8 0.34 11.3 3.8 1.5 1 0 0 1 1 1 0 C1 domain Zn_ribbon_17 PF17120.5 CCF51697.1 - 0.31 10.7 10.4 0.62 9.7 10.4 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type Prok-RING_1 PF14446.6 CCF51697.1 - 1.1 9.3 9.7 2.3 8.2 9.7 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 PHD PF00628.29 CCF51697.1 - 1.3 9.0 9.5 3.5 7.6 9.5 1.7 1 0 0 1 1 1 0 PHD-finger WD40 PF00400.32 CCF51698.1 - 8.9e-22 77.0 16.9 0.00033 21.4 0.1 7.1 6 1 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF51698.1 - 3.7e-08 33.6 4.1 0.023 15.0 0.2 4.3 2 2 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CCF51698.1 - 0.0054 15.7 0.1 1.8 7.4 0.0 3.4 2 2 1 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein EamA PF00892.20 CCF51699.1 - 2e-23 83.1 35.8 5.2e-12 46.1 10.4 2.2 2 0 0 2 2 2 2 EamA-like transporter family DUF2070 PF09843.9 CCF51699.1 - 1.8 6.8 17.1 0.044 12.1 6.2 2.0 2 0 0 2 2 2 0 Predicted membrane protein (DUF2070) Fungal_trans PF04082.18 CCF51700.1 - 1.1e-12 47.6 0.5 2.3e-12 46.5 0.1 1.7 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF51700.1 - 1.8e-06 28.0 9.5 3.6e-06 27.0 9.5 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Hexapep PF00132.24 CCF51701.1 - 5.5e-10 38.6 11.1 2e-05 24.1 1.6 4.5 3 2 0 4 4 4 3 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 CCF51701.1 - 2.4e-07 30.4 6.9 0.0019 17.9 1.0 3.6 3 0 0 3 3 3 3 Hexapeptide repeat of succinyl-transferase Fucokinase PF07959.12 CCF51701.1 - 0.014 14.3 0.4 0.052 12.5 0.1 1.7 1 1 0 2 2 2 0 L-fucokinase Sec1 PF00995.23 CCF51702.1 - 4.5e-132 442.2 0.0 5.1e-132 442.0 0.0 1.0 1 0 0 1 1 1 1 Sec1 family RVT_2 PF07727.14 CCF51703.1 - 4.7e-38 131.2 0.0 5.5e-38 131.0 0.0 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.27 CCF51704.1 - 2.7e-07 30.4 0.0 3.8e-07 29.9 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 CCF51705.1 - 1.6e-17 63.3 1.0 5e-17 61.8 1.0 1.9 1 0 0 1 1 1 1 Integrase zinc binding domain Chromo PF00385.24 CCF51705.1 - 1e-10 41.4 0.5 3.7e-10 39.6 0.1 2.1 2 0 0 2 2 2 1 Chromo (CHRromatin Organisation MOdifier) domain rve PF00665.26 CCF51705.1 - 2.4e-08 34.2 0.0 5e-08 33.1 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain Hexapep PF00132.24 CCF51707.1 - 2e-06 27.3 5.0 0.0023 17.6 5.7 3.2 1 1 2 3 3 3 3 Bacterial transferase hexapeptide (six repeats) NTP_transf_3 PF12804.7 CCF51707.1 - 0.00014 22.2 0.1 0.00036 20.9 0.1 1.7 1 0 0 1 1 1 1 MobA-like NTP transferase domain Hexapep_2 PF14602.6 CCF51707.1 - 0.006 16.3 7.7 0.31 10.8 7.7 2.6 1 1 0 1 1 1 1 Hexapeptide repeat of succinyl-transferase DUF4954 PF16314.5 CCF51707.1 - 0.011 13.9 1.2 0.017 13.3 1.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4954) NTP_transferase PF00483.23 CCF51707.1 - 0.012 15.3 0.0 0.089 12.4 0.1 2.2 2 0 0 2 2 2 0 Nucleotidyl transferase CTP_transf_3 PF02348.19 CCF51707.1 - 0.031 14.2 0.0 0.075 12.9 0.0 1.6 1 0 0 1 1 1 0 Cytidylyltransferase DUF3664 PF12406.8 CCF51707.1 - 0.16 12.6 0.0 0.36 11.5 0.0 1.6 1 0 0 1 1 1 0 Surface protein Fucokinase PF07959.12 CCF51707.1 - 0.19 10.6 1.6 1.3 7.9 1.6 2.0 1 1 0 1 1 1 0 L-fucokinase Aa_trans PF01490.18 CCF51708.1 - 4.4e-72 243.0 18.8 4.4e-72 243.0 18.8 1.7 2 0 0 2 2 2 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 CCF51708.1 - 8.9e-06 25.0 13.1 8.9e-06 25.0 13.1 1.5 2 0 0 2 2 2 1 Tryptophan/tyrosine permease family EVI2A PF05399.11 CCF51709.1 - 0.034 13.7 0.2 0.034 13.7 0.2 1.5 2 0 0 2 2 2 0 Ectropic viral integration site 2A protein (EVI2A) Peptidase_M56 PF05569.11 CCF51709.1 - 0.32 10.2 0.7 0.44 9.7 0.7 1.1 1 0 0 1 1 1 0 BlaR1 peptidase M56 DUF751 PF05421.11 CCF51709.1 - 2.5 8.9 7.4 0.2 12.4 0.8 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF751) DDHD PF02862.17 CCF51710.1 - 2.3e-36 126.1 5.9 3.4e-35 122.2 0.0 3.3 3 0 0 3 3 3 2 DDHD domain Kri1_C PF12936.7 CCF51710.1 - 0.3 11.3 3.4 0.24 11.6 0.4 2.3 2 0 0 2 2 2 0 KRI1-like family C-terminal PACT_coil_coil PF10495.9 CCF51711.1 - 2.5e-14 53.6 4.2 2.5e-14 53.6 4.2 5.8 6 1 0 6 6 6 1 Pericentrin-AKAP-450 domain of centrosomal targeting protein Fez1 PF06818.15 CCF51711.1 - 0.0013 19.3 15.5 0.0013 19.3 15.5 8.5 4 2 6 10 10 10 2 Fez1 JIP_LZII PF16471.5 CCF51711.1 - 0.004 17.3 4.4 0.004 17.3 4.4 9.6 11 3 1 12 12 12 1 JNK-interacting protein leucine zipper II Zn_clus PF00172.18 CCF51713.1 - 1.3e-06 28.5 9.4 1.3e-06 28.5 9.4 2.0 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain zf-C2H2 PF00096.26 CCF51713.1 - 0.0001 22.5 0.2 0.00068 20.0 0.0 2.6 2 0 0 2 2 2 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CCF51713.1 - 0.0029 18.3 0.0 0.014 16.2 0.0 2.2 1 0 0 1 1 1 1 C2H2-type zinc finger DUF1610 PF07754.11 CCF51713.1 - 0.091 12.7 2.5 0.23 11.5 2.5 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1610) ABC_membrane PF00664.23 CCF51714.1 - 4.5e-45 154.4 1.6 6.3e-45 154.0 1.6 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 CCF51714.1 - 1.4e-33 116.3 0.0 2.9e-33 115.3 0.0 1.6 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 CCF51714.1 - 0.00014 21.4 0.1 0.0028 17.1 0.8 1.9 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain ABC_ATPase PF09818.9 CCF51714.1 - 0.0031 16.4 0.0 0.0047 15.8 0.0 1.2 1 0 0 1 1 1 1 Predicted ATPase of the ABC class Zeta_toxin PF06414.12 CCF51714.1 - 0.076 12.3 0.0 0.19 11.0 0.0 1.6 1 0 0 1 1 1 0 Zeta toxin AAA_29 PF13555.6 CCF51714.1 - 0.09 12.5 0.1 0.26 11.1 0.1 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain CLASP_N PF12348.8 CCF51715.1 - 2.8e-26 92.5 0.0 4.8e-26 91.7 0.0 1.4 1 0 0 1 1 1 1 CLASP N terminal Tube PF17212.3 CCF51716.1 - 0.13 12.4 0.0 0.25 11.4 0.0 1.4 1 0 0 1 1 1 0 Tail tubular protein DPBB_1 PF03330.18 CCF51717.1 - 0.00013 22.1 0.4 0.00044 20.5 0.4 1.9 1 1 0 1 1 1 1 Lytic transglycolase TFIIA PF03153.13 CCF51717.1 - 0.0088 16.1 33.0 0.014 15.4 33.0 1.3 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit SID-1_RNA_chan PF13965.6 CCF51717.1 - 0.073 11.5 1.6 0.099 11.0 1.6 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Sporozoite_P67 PF05642.11 CCF51717.1 - 0.13 10.3 20.9 0.17 9.9 20.9 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Hamartin PF04388.12 CCF51717.1 - 0.17 10.5 18.1 0.2 10.3 18.1 1.1 1 0 0 1 1 1 0 Hamartin protein SAPS PF04499.15 CCF51717.1 - 2 7.1 13.0 2.6 6.7 13.0 1.3 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein TFIIF_alpha PF05793.12 CCF51717.1 - 4.6 5.7 27.1 6.2 5.3 27.1 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) DUF4746 PF15928.5 CCF51717.1 - 5.6 6.3 12.0 10 5.4 12.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) CBF PF03914.17 CCF51718.1 - 5.9e-53 179.4 0.2 5.9e-53 179.4 0.2 4.0 4 0 0 4 4 4 1 CBF/Mak21 family Adaptin_N PF01602.20 CCF51718.1 - 0.0067 15.0 0.6 1.1 7.7 0.1 2.8 3 1 0 3 3 3 2 Adaptin N terminal region RVT_2 PF07727.14 CCF51719.1 - 0.0019 17.9 0.0 0.0026 17.4 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF3692 PF12469.8 CCF51719.1 - 0.11 12.7 0.0 0.19 11.9 0.0 1.4 1 0 0 1 1 1 0 CRISPR-associated protein Peptidase_C15 PF01470.17 CCF51720.1 - 6.2e-09 36.3 0.0 0.0042 17.3 0.0 3.2 3 1 1 4 4 4 2 Pyroglutamyl peptidase rve PF00665.26 CCF51721.1 - 1e-12 48.3 0.0 1.7e-12 47.6 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 CCF51721.1 - 0.0029 17.4 0.0 0.0062 16.3 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Spt20 PF12090.8 CCF51722.1 - 0.063 12.9 6.0 0.13 11.8 6.0 1.5 1 0 0 1 1 1 0 Spt20 family CCDC106 PF15794.5 CCF51722.1 - 0.17 11.6 2.2 0.26 11.0 0.2 2.2 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 106 DEAD_assoc PF08494.11 CCF51723.1 - 0.13 12.0 0.1 0.18 11.6 0.1 1.2 1 0 0 1 1 1 0 DEAD/H associated RVT_2 PF07727.14 CCF51724.1 - 8.7e-39 133.6 0.2 4.3e-25 88.8 0.1 2.1 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) Pkinase PF00069.25 CCF51725.1 - 2.6e-65 220.4 0.0 3.7e-65 219.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF51725.1 - 1.4e-45 155.7 0.0 2.2e-45 155.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CCF51725.1 - 1.2e-08 34.2 0.0 6.2e-08 31.8 0.0 2.0 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 CCF51725.1 - 6.5e-07 29.0 0.0 2.3e-06 27.1 0.0 1.8 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 CCF51725.1 - 0.0018 18.3 0.0 2.6 7.9 0.0 2.6 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 CCF51725.1 - 0.14 11.5 0.0 0.29 10.4 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 CCF51725.1 - 0.17 10.8 0.0 1.4 7.8 0.0 2.2 1 1 0 1 1 1 0 Haspin like kinase domain CTP_transf_1 PF01148.20 CCF51726.1 - 2e-70 237.6 16.4 2.7e-65 220.8 8.6 2.2 2 0 0 2 2 2 2 Cytidylyltransferase family LAP1C PF05609.12 CCF51726.1 - 0.024 13.7 13.3 0.028 13.5 12.5 1.4 2 0 0 2 2 2 0 Lamina-associated polypeptide 1C (LAP1C) TFIIA PF03153.13 CCF51726.1 - 0.2 11.6 19.6 0.26 11.3 19.6 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit COX2_TM PF02790.15 CCF51726.1 - 0.35 11.0 3.0 0.74 10.0 0.2 2.6 2 0 0 2 2 2 0 Cytochrome C oxidase subunit II, transmembrane domain DUF2561 PF10812.8 CCF51726.1 - 0.83 9.7 8.6 0.45 10.5 0.2 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2561) RVT_2 PF07727.14 CCF51727.1 - 0.056 13.1 0.0 0.078 12.6 0.0 1.2 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) Forkhead PF00250.18 CCF51729.1 - 7e-11 42.2 0.1 1.5e-10 41.2 0.1 1.5 1 0 0 1 1 1 1 Forkhead domain Ndc1_Nup PF09531.10 CCF51729.1 - 2.1 6.9 19.1 5 5.7 19.1 1.6 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup UCH PF00443.29 CCF51730.1 - 4.5e-44 150.9 0.0 5.9e-44 150.5 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 CCF51730.1 - 9.5e-10 38.6 0.0 1.9e-08 34.3 0.0 2.1 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase DnaJ-X PF14308.6 CCF51731.1 - 1.5e-48 165.0 2.4 1.5e-48 165.0 2.4 1.9 1 1 1 2 2 2 1 X-domain of DnaJ-containing DnaJ PF00226.31 CCF51731.1 - 2.4e-26 91.7 1.7 6.1e-26 90.3 0.8 2.2 2 0 0 2 2 2 1 DnaJ domain Las1 PF04031.13 CCF51732.1 - 2.6e-43 147.8 0.2 6.3e-43 146.5 0.2 1.6 1 0 0 1 1 1 1 Las1-like Pet127 PF08634.10 CCF51736.1 - 1.4e-106 356.0 0.1 2.3e-106 355.2 0.1 1.4 1 0 0 1 1 1 1 Mitochondrial protein Pet127 Ribosomal_L6e PF01159.19 CCF51737.1 - 2.2e-38 131.2 1.5 2.2e-38 131.2 1.5 1.7 2 0 0 2 2 2 1 Ribosomal protein L6e Aminotran_4 PF01063.19 CCF51738.1 - 0.096 12.5 0.0 0.12 12.2 0.0 1.2 1 0 0 1 1 1 0 Amino-transferase class IV Thi4 PF01946.17 CCF51739.1 - 1.4e-100 335.4 0.2 1.7e-100 335.1 0.2 1.1 1 0 0 1 1 1 1 Thi4 family DAO PF01266.24 CCF51739.1 - 1.7e-08 34.5 2.2 5.8e-08 32.7 1.2 1.9 1 1 1 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CCF51739.1 - 1.5e-07 31.5 0.2 3.9e-07 30.2 0.2 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 CCF51739.1 - 2.1e-07 30.3 0.6 1.6e-05 24.1 0.3 2.1 2 0 0 2 2 2 2 Lycopene cyclase protein FAD_binding_2 PF00890.24 CCF51739.1 - 1.4e-05 24.4 1.0 0.0002 20.5 0.5 2.1 2 0 0 2 2 2 1 FAD binding domain NAD_binding_9 PF13454.6 CCF51739.1 - 2.2e-05 24.5 0.4 0.00069 19.6 0.1 2.8 3 0 0 3 3 3 1 FAD-NAD(P)-binding Pyr_redox_2 PF07992.14 CCF51739.1 - 3e-05 23.4 0.1 4.2e-05 22.9 0.1 1.3 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CCF51739.1 - 0.0012 17.6 0.2 0.0019 17.0 0.2 1.2 1 0 0 1 1 1 1 HI0933-like protein GIDA PF01134.22 CCF51739.1 - 0.0099 15.0 0.0 0.048 12.7 0.0 1.8 2 0 0 2 2 2 1 Glucose inhibited division protein A Pyr_redox_3 PF13738.6 CCF51739.1 - 0.014 14.6 0.1 0.023 14.0 0.1 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 CCF51739.1 - 0.024 13.5 0.2 0.036 12.9 0.2 1.2 1 0 0 1 1 1 0 Tryptophan halogenase FAD_oxidored PF12831.7 CCF51739.1 - 0.038 13.4 1.0 0.046 13.1 1.0 1.3 1 1 0 1 1 1 0 FAD dependent oxidoreductase DUF4387 PF14330.6 CCF51739.1 - 0.12 13.1 0.0 0.69 10.6 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4387) Amino_oxidase PF01593.24 CCF51739.1 - 0.18 11.0 0.0 0.31 10.3 0.0 1.4 1 0 0 1 1 1 0 Flavin containing amine oxidoreductase Xpo1 PF08389.12 CCF51740.1 - 5.1e-18 65.5 10.1 1.1e-15 58.0 0.1 4.9 6 0 0 6 6 6 2 Exportin 1-like protein DUF2150 PF09920.9 CCF51740.1 - 0.0057 16.6 0.1 0.016 15.2 0.1 1.7 1 0 0 1 1 1 1 Uncharacterized protein conserved in archaea (DUF2150) Importin_rep_4 PF18808.1 CCF51740.1 - 0.065 13.5 0.3 0.3 11.4 0.3 2.2 1 0 0 1 1 1 0 Importin repeat HEAT_EZ PF13513.6 CCF51740.1 - 0.23 12.0 1.3 1.6 9.3 0.1 3.2 3 0 0 3 3 3 0 HEAT-like repeat HEAT PF02985.22 CCF51740.1 - 0.34 11.3 2.4 47 4.6 0.0 4.8 5 1 1 6 6 6 0 HEAT repeat rve PF00665.26 CCF51741.1 - 1.8e-09 37.8 0.0 3.9e-09 36.7 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain gag_pre-integrs PF13976.6 CCF51741.1 - 2.2e-07 30.6 0.4 5.8e-07 29.3 0.4 1.7 1 0 0 1 1 1 1 GAG-pre-integrase domain zf-CCHC PF00098.23 CCF51742.1 - 0.014 15.4 0.1 0.038 14.1 0.1 1.8 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_6 PF15288.6 CCF51742.1 - 0.059 13.2 0.4 0.16 11.8 0.4 1.8 1 0 0 1 1 1 0 Zinc knuckle NeuB PF03102.14 CCF51742.1 - 0.074 12.5 0.1 0.22 10.9 0.0 1.8 2 0 0 2 2 2 0 NeuB family HSF_DNA-bind PF00447.17 CCF51743.1 - 2.3e-20 73.0 0.0 4.5e-20 72.1 0.0 1.5 1 0 0 1 1 1 1 HSF-type DNA-binding NOA36 PF06524.12 CCF51743.1 - 2.8 7.2 13.8 0.61 9.4 3.6 2.3 2 0 0 2 2 2 0 NOA36 protein FYDLN_acid PF09538.10 CCF51743.1 - 4.3 8.1 15.4 2.9 8.6 1.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (FYDLN_acid) RXT2_N PF08595.11 CCF51743.1 - 5.2 7.1 11.5 4.7 7.2 1.5 2.6 2 0 0 2 2 2 0 RXT2-like, N-terminal PRP1_N PF06424.12 CCF51744.1 - 7.3e-48 162.7 4.1 2.2e-47 161.2 4.1 1.9 1 0 0 1 1 1 1 PRP1 splicing factor, N-terminal TPR_14 PF13428.6 CCF51744.1 - 2.8e-19 68.2 23.9 0.03 15.2 0.0 11.9 11 3 3 14 14 14 6 Tetratricopeptide repeat TPR_19 PF14559.6 CCF51744.1 - 3.2e-11 43.6 9.1 0.061 13.8 0.0 9.2 9 1 1 10 10 10 3 Tetratricopeptide repeat TPR_9 PF13371.6 CCF51744.1 - 0.00028 21.0 0.1 1.7 8.8 0.0 3.8 3 1 1 4 4 4 2 Tetratricopeptide repeat Suf PF05843.14 CCF51744.1 - 0.00056 20.0 0.5 14 5.5 0.0 4.6 5 0 0 5 5 5 1 Suppressor of forked protein (Suf) TPR_16 PF13432.6 CCF51744.1 - 0.052 14.2 4.8 13 6.5 0.0 5.4 5 1 1 6 6 6 0 Tetratricopeptide repeat Thioredoxin_3 PF13192.6 CCF51744.1 - 0.15 12.1 0.0 0.63 10.1 0.0 2.2 1 0 0 1 1 1 0 Thioredoxin domain Phasin PF05597.11 CCF51744.1 - 0.75 9.8 6.8 0.16 12.0 1.4 2.6 2 0 0 2 2 2 0 Poly(hydroxyalcanoate) granule associated protein (phasin) NARP1 PF12569.8 CCF51744.1 - 2.8 6.7 8.4 1.5 7.6 0.1 3.8 4 1 1 5 5 5 0 NMDA receptor-regulated protein 1 DER1 PF04511.15 CCF51745.1 - 1.3e-49 168.8 6.2 1.4e-49 168.6 6.2 1.0 1 0 0 1 1 1 1 Der1-like family DUF962 PF06127.11 CCF51746.1 - 5.2e-24 84.1 0.0 1.1e-23 83.1 0.0 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF962) DUF3681 PF12442.8 CCF51746.1 - 0.79 10.2 4.5 0.37 11.3 1.3 2.0 2 1 0 2 2 2 0 Protein of unknown function (DUF3681) Nt_Gln_amidase PF09764.9 CCF51747.1 - 1.4e-48 165.0 0.0 2.1e-48 164.4 0.0 1.2 1 0 0 1 1 1 1 N-terminal glutamine amidase HAT_KAT11 PF08214.11 CCF51748.1 - 4.6e-33 115.0 0.0 1e-25 90.8 0.0 2.8 2 1 0 2 2 2 2 Histone acetylation protein zf-ANAPC11 PF12861.7 CCF51749.1 - 2.5e-32 110.8 11.4 3.2e-32 110.4 11.4 1.2 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.7 CCF51749.1 - 4.2e-20 71.8 14.5 5.8e-20 71.3 14.5 1.2 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 CCF51749.1 - 1.6e-07 31.6 17.0 1.9e-06 28.1 17.0 2.1 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 CCF51749.1 - 0.0011 18.8 12.4 0.0047 16.8 12.4 2.0 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 CCF51749.1 - 0.0011 18.8 18.9 0.0016 18.3 15.1 2.5 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 CCF51749.1 - 0.0029 17.4 13.6 0.061 13.2 13.6 2.2 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CCF51749.1 - 0.044 13.8 11.0 0.13 12.3 11.0 1.9 1 1 0 1 1 1 0 RING-type zinc-finger zf-RING_11 PF17123.5 CCF51749.1 - 0.11 12.3 14.0 2.4 8.0 14.0 2.3 1 1 0 1 1 1 0 RING-like zinc finger zf-RING_5 PF14634.6 CCF51749.1 - 0.2 11.6 14.5 1.2 9.2 14.7 2.0 1 1 1 2 2 2 0 zinc-RING finger domain zf-HC5HC2H_2 PF13832.6 CCF51749.1 - 0.24 11.6 9.1 0.13 12.4 7.0 1.6 1 1 0 1 1 1 0 PHD-zinc-finger like domain zf-RING_4 PF14570.6 CCF51749.1 - 0.41 10.5 15.8 2.1 8.2 11.7 2.4 1 1 2 3 3 3 0 RING/Ubox like zinc-binding domain FANCL_C PF11793.8 CCF51749.1 - 0.81 9.9 13.8 2.9 8.1 13.8 1.9 1 1 0 1 1 1 0 FANCL C-terminal domain Na_H_Exchanger PF00999.21 CCF51750.1 - 4e-67 226.6 21.0 5.1e-67 226.3 21.0 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family DUF4396 PF14342.6 CCF51750.1 - 0.054 13.9 0.1 0.15 12.4 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4396) Mis12 PF05859.12 CCF51750.1 - 0.16 12.0 0.0 0.5 10.4 0.0 1.8 1 0 0 1 1 1 0 Mis12 protein YrhC PF14143.6 CCF51750.1 - 0.22 11.6 0.5 0.72 10.0 0.5 1.8 1 0 0 1 1 1 0 YrhC-like protein LIDHydrolase PF10230.9 CCF51750.1 - 0.25 10.9 0.1 0.44 10.1 0.1 1.3 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase PIG-F PF06699.11 CCF51751.1 - 1.2e-12 48.4 1.5 3.5e-05 24.0 0.0 2.3 2 1 0 2 2 2 2 GPI biosynthesis protein family Pig-F Ish1 PF10281.9 CCF51752.1 - 1.3e-65 217.4 28.1 3.4e-13 49.7 0.2 6.5 6 0 0 6 6 6 6 Putative stress-responsive nuclear envelope protein Rap1_C PF11626.8 CCF51752.1 - 0.035 14.2 1.4 0.095 12.8 0.5 2.2 2 0 0 2 2 2 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain SAP PF02037.27 CCF51752.1 - 0.08 12.7 0.0 25 4.8 0.0 3.9 4 0 0 4 4 4 0 SAP domain GYF PF02213.16 CCF51752.1 - 0.11 12.2 1.6 1.3 8.8 0.4 2.7 1 1 1 2 2 2 0 GYF domain UPF0183 PF03676.14 CCF51753.1 - 4.2e-42 144.8 0.0 9.9e-27 94.2 0.0 4.2 2 1 0 2 2 2 2 Uncharacterised protein family (UPF0183) Syntaxin PF00804.25 CCF51754.1 - 0.014 15.1 4.1 0.014 15.1 4.1 1.8 2 0 0 2 2 2 0 Syntaxin Prominin PF05478.11 CCF51754.1 - 0.018 13.0 3.1 0.011 13.8 0.8 1.7 2 0 0 2 2 2 0 Prominin DUF1664 PF07889.12 CCF51754.1 - 0.018 15.1 0.6 0.061 13.4 0.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Syntaxin_2 PF14523.6 CCF51754.1 - 0.027 14.8 1.1 0.29 11.5 1.2 2.2 2 0 0 2 2 2 0 Syntaxin-like protein Emaravirus_P4 PF16505.5 CCF51754.1 - 0.15 11.1 0.7 0.22 10.5 0.7 1.2 1 0 0 1 1 1 0 P4 movement protein of Emaravirus, and the 30K superfamily HisKA PF00512.25 CCF51754.1 - 0.18 11.8 3.5 31 4.7 3.5 2.5 1 1 0 1 1 1 0 His Kinase A (phospho-acceptor) domain Herpes_UL36 PF03586.13 CCF51754.1 - 0.26 10.6 1.7 1.3 8.3 0.2 2.0 2 0 0 2 2 2 0 Herpesvirus UL36 tegument protein Syntaxin-6_N PF09177.11 CCF51754.1 - 0.56 10.8 5.4 1.4 9.5 2.2 2.1 2 0 0 2 2 2 0 Syntaxin 6, N-terminal zf-C4H2 PF10146.9 CCF51754.1 - 1.3 9.3 6.3 0.29 11.4 2.4 1.8 2 0 0 2 2 2 0 Zinc finger-containing protein DUF4200 PF13863.6 CCF51754.1 - 3.5 8.0 10.7 0.45 10.9 6.7 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) G_glu_transpept PF01019.21 CCF51755.1 - 1.2e-159 532.4 0.0 2.9e-159 531.2 0.0 1.6 1 1 0 1 1 1 1 Gamma-glutamyltranspeptidase DUF3094 PF11293.8 CCF51755.1 - 0.16 11.7 0.0 0.45 10.3 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3094) RRM_1 PF00076.22 CCF51756.1 - 3.5e-44 148.5 0.0 2.1e-17 62.7 0.0 4.8 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 CCF51756.1 - 4.4e-09 36.1 0.0 0.27 11.1 0.0 4.5 4 0 0 4 4 4 3 Occluded RNA-recognition motif RRM_7 PF16367.5 CCF51756.1 - 2.5e-06 27.5 0.0 0.042 14.0 0.0 3.7 4 0 0 4 4 4 2 RNA recognition motif RRM_3 PF08777.11 CCF51756.1 - 0.00023 21.1 0.0 0.13 12.3 0.0 3.2 3 0 0 3 3 3 1 RNA binding motif RNA_bind PF08675.11 CCF51756.1 - 0.00094 19.2 0.0 0.0074 16.3 0.0 2.5 3 0 0 3 3 3 1 RNA binding domain Nup35_RRM_2 PF14605.6 CCF51756.1 - 0.0025 17.8 0.0 6.5 6.8 0.0 4.2 4 0 0 4 4 4 1 Nup53/35/40-type RNA recognition motif BAF1_ABF1 PF04684.13 CCF51756.1 - 0.39 9.7 3.1 0.59 9.1 3.1 1.2 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor CUE PF02845.16 CCF51758.1 - 3.5e-10 39.4 0.0 5.9e-10 38.7 0.0 1.4 1 0 0 1 1 1 1 CUE domain DUF3697 PF12478.8 CCF51758.1 - 0.055 13.6 0.3 0.16 12.1 0.3 1.8 1 0 0 1 1 1 0 Ubiquitin-associated protein 2 DUF1296 PF06972.11 CCF51758.1 - 0.09 12.9 0.0 0.15 12.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1296) RhoGEF PF00621.20 CCF51759.1 - 3.2e-19 69.9 0.0 5.2e-15 56.2 0.0 2.2 2 0 0 2 2 2 2 RhoGEF domain Malic_M PF03949.15 CCF51761.1 - 5e-87 291.4 0.0 6.7e-87 291.0 0.0 1.2 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.19 CCF51761.1 - 3.4e-67 225.8 0.0 5.2e-67 225.2 0.0 1.3 1 0 0 1 1 1 1 Malic enzyme, N-terminal domain SSFA2_C PF14723.6 CCF51761.1 - 0.0076 16.2 0.1 0.013 15.4 0.1 1.3 1 0 0 1 1 1 1 Sperm-specific antigen 2 C-terminus DUF3276 PF11680.8 CCF51761.1 - 0.15 12.2 0.0 0.29 11.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3276) Catalase PF00199.19 CCF51763.1 - 5.6e-169 562.3 0.0 7.4e-169 561.9 0.0 1.1 1 0 0 1 1 1 1 Catalase Catalase-rel PF06628.12 CCF51763.1 - 3.3e-16 59.2 0.0 7.6e-16 58.1 0.0 1.7 1 0 0 1 1 1 1 Catalase-related immune-responsive DSPc PF00782.20 CCF51764.1 - 4.8e-29 100.9 0.0 7.5e-29 100.2 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase2 PF03162.13 CCF51764.1 - 0.0027 17.3 0.0 0.005 16.4 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.27 CCF51764.1 - 0.0049 16.5 0.0 0.0089 15.6 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Init_tRNA_PT PF04179.12 CCF51764.1 - 0.023 15.0 0.0 0.061 13.6 0.0 1.7 1 0 0 1 1 1 0 Rit1 DUSP-like domain Y_phosphatase3 PF13350.6 CCF51764.1 - 0.063 13.2 0.0 0.12 12.4 0.0 1.4 1 0 0 1 1 1 0 Tyrosine phosphatase family DUF4597 PF15366.6 CCF51764.1 - 0.28 11.0 2.3 1.4 8.7 0.4 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4597) SERTA PF06031.13 CCF51766.1 - 0.0069 16.0 0.1 0.019 14.7 0.1 1.8 2 0 0 2 2 2 1 SERTA motif Ad_cyc_g-alpha PF08509.11 CCF51767.1 - 0.07 12.9 0.0 0.15 11.8 0.0 1.5 1 0 0 1 1 1 0 Adenylate cyclase G-alpha binding domain Alpha-amylase PF00128.24 CCF51769.1 - 2.1e-22 80.1 1.0 4.6e-18 65.9 0.1 2.5 2 1 0 2 2 2 2 Alpha amylase, catalytic domain Glyco_hydro_70 PF02324.16 CCF51769.1 - 4.8e-08 31.7 2.0 0.012 13.9 0.1 3.1 3 0 0 3 3 3 3 Glycosyl hydrolase family 70 DUF1939 PF09154.10 CCF51769.1 - 2.6e-05 24.3 0.7 0.00011 22.2 0.3 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF1939) Alpha-amylase_C PF02806.18 CCF51769.1 - 0.00018 21.9 0.8 0.00053 20.4 0.1 2.2 2 0 0 2 2 2 1 Alpha amylase, C-terminal all-beta domain Mitochondr_Som1 PF11093.8 CCF51770.1 - 3.1e-06 27.1 0.5 6.4e-06 26.1 0.5 1.4 1 0 0 1 1 1 1 Mitochondrial export protein Som1 PHD PF00628.29 CCF51772.1 - 2.8e-07 30.3 10.4 5.7e-07 29.3 10.4 1.6 1 0 0 1 1 1 1 PHD-finger Prok-RING_1 PF14446.6 CCF51772.1 - 0.00083 19.2 4.4 0.0014 18.5 4.4 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 1 zf-HC5HC2H PF13771.6 CCF51772.1 - 0.026 14.8 3.0 0.06 13.6 3.0 1.6 1 0 0 1 1 1 0 PHD-like zinc-binding domain zf-CSL PF05207.13 CCF51772.1 - 0.39 10.5 4.7 1.2 8.9 4.7 1.8 1 0 0 1 1 1 0 CSL zinc finger C1_2 PF03107.16 CCF51772.1 - 1.6 9.1 5.4 0.8 10.1 2.2 2.0 2 0 0 2 2 2 0 C1 domain SAP30_Sin3_bdg PF13867.6 CCF51773.1 - 8.6e-05 22.8 0.1 0.00036 20.8 0.0 2.0 3 0 0 3 3 3 1 Sin3 binding region of histone deacetylase complex subunit SAP30 Mg_trans_NIPA PF05653.14 CCF51775.1 - 2.6e-62 210.6 3.6 4e-59 200.1 2.6 2.1 2 0 0 2 2 2 2 Magnesium transporter NIPA EamA PF00892.20 CCF51775.1 - 0.00034 20.8 3.2 0.00034 20.8 3.2 3.3 3 1 0 3 3 3 1 EamA-like transporter family MccV PF17508.2 CCF51775.1 - 0.045 14.3 2.7 0.14 12.7 2.7 1.8 1 0 0 1 1 1 0 Microcin V bacteriocin Oxidored_q6 PF01058.22 CCF51775.1 - 0.14 12.0 0.0 0.27 11.0 0.0 1.4 1 0 0 1 1 1 0 NADH ubiquinone oxidoreductase, 20 Kd subunit FAM176 PF14851.6 CCF51775.1 - 0.14 11.8 2.1 5.6 6.6 0.3 2.7 3 0 0 3 3 3 0 FAM176 family DUF2370 PF10176.9 CCF51775.1 - 0.22 11.2 0.6 0.39 10.3 0.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) DUF3021 PF11457.8 CCF51775.1 - 0.56 10.5 5.2 0.25 11.7 0.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3021) Coprogen_oxidas PF01218.18 CCF51776.1 - 3.9e-123 409.9 0.0 8.1e-123 408.9 0.0 1.5 1 1 0 1 1 1 1 Coproporphyrinogen III oxidase Lactonase PF10282.9 CCF51778.1 - 9.3e-70 235.6 0.6 1.2e-69 235.2 0.6 1.1 1 0 0 1 1 1 1 Lactonase, 7-bladed beta-propeller YmzC PF14157.6 CCF51778.1 - 0.00073 19.6 0.7 3.5 7.8 0.0 3.8 3 1 1 4 4 4 2 YmzC-like protein Lipase_C PF18067.1 CCF51778.1 - 0.0094 16.5 0.0 5.1 7.7 0.0 3.0 2 0 0 2 2 2 2 Lipase C-terminal domain Amidase_6 PF12671.7 CCF51778.1 - 0.16 12.0 0.4 4.8 7.3 0.1 2.7 2 1 0 2 2 2 0 Putative amidase domain Nup54 PF13874.6 CCF51779.1 - 1.3e-33 116.0 2.6 4.2e-33 114.4 2.6 1.8 1 1 0 1 1 1 1 Nucleoporin complex subunit 54 Nup54_C PF18437.1 CCF51779.1 - 0.0011 18.8 0.2 0.0031 17.4 0.2 1.8 1 0 0 1 1 1 1 Nup54 C-terminal interacting domain GTP-bdg_M PF16360.5 CCF51779.1 - 2.8 8.6 6.4 0.72 10.5 0.8 2.8 1 1 1 2 2 2 0 GTP-binding GTPase Middle Region DUF1748 PF08520.10 CCF51780.1 - 1.1e-25 89.3 0.0 1.3e-25 89.1 0.0 1.0 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1748) BAR PF03114.18 CCF51782.1 - 4.5e-20 72.3 0.1 6.5e-20 71.8 0.1 1.2 1 0 0 1 1 1 1 BAR domain APG6_N PF17675.1 CCF51782.1 - 0.26 11.8 6.7 0.65 10.5 6.7 1.6 1 0 0 1 1 1 0 Apg6 coiled-coil region DUF3584 PF12128.8 CCF51782.1 - 0.43 8.0 7.6 0.58 7.6 7.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Pex14_N PF04695.13 CCF51783.1 - 9.5e-27 94.6 1.1 9.5e-27 94.6 1.1 3.3 2 1 0 2 2 2 1 Peroxisomal membrane anchor protein (Pex14p) conserved region CALCOCO1 PF07888.11 CCF51783.1 - 2.4e-05 23.4 5.1 3.4e-05 22.9 5.1 1.1 1 0 0 1 1 1 1 Calcium binding and coiled-coil domain (CALCOCO1) like MIP-T3_C PF17749.1 CCF51783.1 - 0.0018 18.3 1.8 0.32 10.9 0.9 2.5 2 0 0 2 2 2 1 Microtubule-binding protein MIP-T3 C-terminal region DUF3829 PF12889.7 CCF51783.1 - 0.0037 16.8 0.2 0.0037 16.8 0.2 1.9 2 1 1 3 3 2 1 Protein of unknown function (DUF3829) FTA4 PF13093.6 CCF51783.1 - 0.0051 16.7 3.9 0.0054 16.6 1.7 2.0 2 0 0 2 2 2 1 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 Fez1 PF06818.15 CCF51783.1 - 0.0057 17.1 2.7 0.0092 16.4 2.7 1.3 1 0 0 1 1 1 1 Fez1 Golgin_A5 PF09787.9 CCF51783.1 - 0.0077 15.7 2.8 0.013 15.0 2.8 1.3 1 0 0 1 1 1 1 Golgin subfamily A member 5 DUF4407 PF14362.6 CCF51783.1 - 0.0078 15.6 0.8 0.011 15.1 0.8 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4407) Spc7 PF08317.11 CCF51783.1 - 0.013 14.4 4.9 0.02 13.8 4.9 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF3584 PF12128.8 CCF51783.1 - 0.017 12.7 4.0 0.022 12.3 4.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DUF948 PF06103.11 CCF51783.1 - 0.033 14.4 2.6 7.2 6.9 1.8 2.4 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) DUF1664 PF07889.12 CCF51783.1 - 0.045 13.8 7.9 0.13 12.3 5.3 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) Matrilin_ccoil PF10393.9 CCF51783.1 - 0.047 13.5 0.5 0.35 10.8 0.3 2.3 2 0 0 2 2 2 0 Trimeric coiled-coil oligomerisation domain of matrilin Baculo_PEP_C PF04513.12 CCF51783.1 - 0.055 13.5 1.1 0.1 12.7 1.1 1.4 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus FUSC PF04632.12 CCF51783.1 - 0.059 11.9 0.0 0.085 11.4 0.0 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family Atg14 PF10186.9 CCF51783.1 - 0.078 12.1 2.5 0.12 11.4 2.5 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 TPR_MLP1_2 PF07926.12 CCF51783.1 - 0.086 12.9 8.1 0.21 11.6 3.8 2.4 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein Spectrin PF00435.21 CCF51783.1 - 0.096 13.2 3.4 0.11 13.0 1.2 2.1 2 0 0 2 2 2 0 Spectrin repeat RasGAP_C PF03836.15 CCF51783.1 - 0.11 12.7 1.1 0.18 11.9 1.1 1.3 1 0 0 1 1 1 0 RasGAP C-terminus Vac_Fusion PF02346.16 CCF51783.1 - 0.12 12.0 0.2 0.57 9.9 0.1 2.2 3 0 0 3 3 2 0 Chordopoxvirus multifunctional envelope protein A27 ADIP PF11559.8 CCF51783.1 - 0.17 12.0 2.9 0.12 12.4 0.4 1.9 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding Enkurin PF13864.6 CCF51783.1 - 0.18 12.2 2.4 0.21 12.0 0.7 1.8 1 1 1 2 2 2 0 Calmodulin-binding DUF2968 PF11180.8 CCF51783.1 - 0.22 11.1 5.0 0.72 9.5 5.0 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF2968) CEP63 PF17045.5 CCF51783.1 - 0.24 11.3 5.7 0.43 10.5 5.7 1.4 1 0 0 1 1 1 0 Centrosomal protein of 63 kDa EzrA PF06160.12 CCF51783.1 - 0.27 9.3 6.1 2.6 6.1 6.5 1.8 1 1 0 1 1 1 0 Septation ring formation regulator, EzrA Laminin_II PF06009.12 CCF51783.1 - 0.32 11.0 4.1 1.6 8.7 4.2 2.0 1 1 0 1 1 1 0 Laminin Domain II BshC PF10079.9 CCF51783.1 - 0.39 9.4 1.6 0.56 8.9 1.6 1.2 1 0 0 1 1 1 0 Bacillithiol biosynthesis BshC HemX PF04375.14 CCF51783.1 - 0.41 9.9 5.1 0.55 9.5 3.6 1.9 1 1 1 2 2 2 0 HemX, putative uroporphyrinogen-III C-methyltransferase Sec20 PF03908.13 CCF51783.1 - 0.65 10.0 3.0 6.1 6.8 0.3 2.3 2 0 0 2 2 2 0 Sec20 ERM PF00769.19 CCF51783.1 - 0.77 9.5 10.2 10 5.9 10.2 2.2 1 1 0 1 1 1 0 Ezrin/radixin/moesin family LXG PF04740.12 CCF51783.1 - 0.79 9.4 6.1 0.89 9.2 3.5 2.2 2 1 1 3 3 3 0 LXG domain of WXG superfamily APG6_N PF17675.1 CCF51783.1 - 0.84 10.2 10.6 0.95 10.0 3.9 2.3 1 1 1 2 2 2 0 Apg6 coiled-coil region DUF148 PF02520.17 CCF51783.1 - 1.1 9.3 4.2 1.3 9.2 1.3 2.2 1 1 1 2 2 2 0 Domain of unknown function DUF148 COG2 PF06148.11 CCF51783.1 - 2.6 8.1 5.8 1 9.4 1.2 2.1 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 HALZ PF02183.18 CCF51783.1 - 4.9 7.4 7.4 2.7 8.3 0.5 2.4 2 0 0 2 2 2 0 Homeobox associated leucine zipper Uds1 PF15456.6 CCF51783.1 - 6.3 7.0 8.9 17 5.6 0.3 3.6 1 1 2 3 3 3 0 Up-regulated During Septation Med9 PF07544.13 CCF51783.1 - 8.3 6.6 6.6 26 5.0 0.8 2.6 1 1 1 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 BST2 PF16716.5 CCF51783.1 - 8.4 7.1 8.7 16 6.2 2.9 2.6 2 0 0 2 2 2 0 Bone marrow stromal antigen 2 RNA_pol_L_2 PF13656.6 CCF51784.1 - 8.3e-30 102.4 0.0 1e-29 102.1 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.24 CCF51784.1 - 6.8e-12 44.6 0.0 9.5e-12 44.2 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain MBOAT_2 PF13813.6 CCF51785.1 - 1e-11 44.9 3.3 1e-11 44.9 3.3 2.3 3 0 0 3 3 3 1 Membrane bound O-acyl transferase family Myb_DNA-binding PF00249.31 CCF51786.1 - 2.5e-17 62.8 0.0 5.3e-09 36.1 0.0 2.5 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 CCF51786.1 - 3.7e-17 62.3 0.0 8.2e-08 32.4 0.0 2.8 2 0 0 2 2 2 2 Myb-like DNA-binding domain SLIDE PF09111.10 CCF51786.1 - 0.0015 18.5 10.1 0.29 11.2 0.0 3.7 3 0 0 3 3 3 1 SLIDE SR-25 PF10500.9 CCF51786.1 - 0.0017 18.0 9.6 0.0017 18.0 9.6 4.7 5 1 1 6 6 6 1 Nuclear RNA-splicing-associated protein MMU163 PF17119.5 CCF51786.1 - 4.7 6.3 8.1 26 3.9 8.1 2.3 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis Cellulose_synt PF03552.14 CCF51786.1 - 8.1 4.8 5.6 13 4.1 5.6 1.2 1 0 0 1 1 1 0 Cellulose synthase ABC2_membrane_2 PF12679.7 CCF51786.1 - 8.3 5.6 5.1 15 4.8 5.1 1.4 1 0 0 1 1 1 0 ABC-2 family transporter protein CMS1 PF14617.6 CCF51786.1 - 9.5 5.5 11.5 19 4.5 11.5 1.4 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit CTU2 PF10288.9 CCF51787.1 - 6.6e-31 106.9 0.4 3.7e-30 104.4 0.1 2.4 2 0 0 2 2 2 1 Cytoplasmic tRNA 2-thiolation protein 2 Calsequestrin PF01216.17 CCF51787.1 - 0.18 10.8 0.0 0.29 10.1 0.0 1.2 1 0 0 1 1 1 0 Calsequestrin Peptidase_M22 PF00814.25 CCF51788.1 - 5.8e-79 265.6 0.0 3.4e-56 190.9 0.0 2.0 1 1 0 2 2 2 2 Glycoprotease family DUF3446 PF11928.8 CCF51788.1 - 0.057 13.7 5.0 0.17 12.2 5.0 1.8 1 0 0 1 1 1 0 Early growth response N-terminal domain APG5 PF04106.12 CCF51789.1 - 1.3e-69 234.3 0.0 1.7e-69 233.9 0.0 1.1 1 0 0 1 1 1 1 Autophagy protein Apg5 zf-CCHC PF00098.23 CCF51790.1 - 1.4e-06 28.1 2.5 3.2e-06 26.9 2.5 1.6 1 0 0 1 1 1 1 Zinc knuckle TFIID_20kDa PF03847.13 CCF51791.1 - 8.9e-30 103.0 0.6 1.4e-29 102.3 0.6 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A CBFD_NFYB_HMF PF00808.23 CCF51791.1 - 0.017 15.4 0.0 0.038 14.3 0.0 1.6 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CBF PF03914.17 CCF51793.1 - 3.3e-28 98.9 0.1 3.3e-28 98.9 0.1 2.8 3 0 0 3 3 3 1 CBF/Mak21 family RR_TM4-6 PF06459.12 CCF51793.1 - 0.11 12.3 9.9 0.11 12.4 4.1 2.4 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 DUF2201_N PF13203.6 CCF51793.1 - 3.3 7.2 8.5 1.7 8.2 1.7 2.5 2 0 0 2 2 2 0 Putative metallopeptidase domain CDC45 PF02724.14 CCF51793.1 - 4.3 5.5 20.3 1.4 7.1 6.3 2.2 2 0 0 2 2 2 0 CDC45-like protein DUF2052 PF09747.9 CCF51793.1 - 5.9 7.0 18.7 0.82 9.8 6.3 2.9 3 0 0 3 3 3 0 Coiled-coil domain containing protein (DUF2052) Myc_N PF01056.18 CCF51793.1 - 7.8 6.3 9.8 27 4.5 4.2 2.5 2 0 0 2 2 2 0 Myc amino-terminal region Pkinase PF00069.25 CCF51794.1 - 2e-66 224.1 0.0 2.6e-66 223.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF51794.1 - 6.3e-29 101.0 0.1 1.5e-28 99.8 0.1 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 CCF51794.1 - 0.002 17.5 0.2 0.0035 16.7 0.2 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 CCF51794.1 - 0.0052 15.8 0.1 0.01 14.8 0.1 1.4 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 CCF51794.1 - 0.014 14.8 0.0 0.035 13.4 0.0 1.6 1 1 0 1 1 1 0 Kinase-like Phage_sheath_1C PF17482.2 CCF51794.1 - 0.032 14.2 0.1 0.091 12.7 0.0 1.8 2 0 0 2 2 2 0 Phage tail sheath C-terminal domain RIO1 PF01163.22 CCF51794.1 - 0.061 12.9 0.1 0.11 12.0 0.1 1.4 1 0 0 1 1 1 0 RIO1 family APH PF01636.23 CCF51794.1 - 0.24 11.3 1.4 0.46 10.4 0.2 2.0 2 1 0 2 2 2 0 Phosphotransferase enzyme family DUF4366 PF14283.6 CCF51796.1 - 0.16 12.0 0.1 0.3 11.1 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) Presenilin PF01080.17 CCF51796.1 - 0.26 10.0 2.4 0.61 8.8 2.4 1.6 1 0 0 1 1 1 0 Presenilin Tyr_Deacylase PF02580.16 CCF51797.1 - 1.3e-47 161.9 0.0 6.4e-47 159.7 0.0 1.8 1 1 0 1 1 1 1 D-Tyr-tRNA(Tyr) deacylase DUF2593 PF10767.9 CCF51797.1 - 0.24 11.5 0.0 0.36 10.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2593) DUF4112 PF13430.6 CCF51799.1 - 2.9e-31 107.9 0.1 3.8e-31 107.5 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4112) WD40 PF00400.32 CCF51800.1 - 3.4e-08 34.0 7.2 0.00067 20.4 0.1 4.8 4 0 0 4 4 4 3 WD domain, G-beta repeat PQQ_3 PF13570.6 CCF51800.1 - 0.0017 18.8 6.4 4.2 8.0 0.1 5.1 4 1 1 5 5 5 2 PQQ-like domain Syntaxin_2 PF14523.6 CCF51801.1 - 1.3e-17 64.0 5.7 3.9e-17 62.5 1.2 2.5 2 1 0 2 2 2 1 Syntaxin-like protein SNARE PF05739.19 CCF51801.1 - 3.6e-11 42.9 0.5 3.6e-11 42.9 0.5 1.9 2 0 0 2 2 2 1 SNARE domain Syntaxin PF00804.25 CCF51801.1 - 0.0061 16.3 10.1 0.15 11.8 10.1 2.4 1 1 0 1 1 1 1 Syntaxin UPF0242 PF06785.11 CCF51801.1 - 0.33 11.1 8.8 0.53 10.4 8.1 1.5 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DUF16 PF01519.16 CCF51801.1 - 7.7 7.1 12.7 0.35 11.4 0.2 3.0 2 1 1 3 3 3 0 Protein of unknown function DUF16 Ribosomal_S4 PF00163.19 CCF51802.1 - 1.7e-11 44.9 0.4 2.9e-11 44.1 0.4 1.5 1 0 0 1 1 1 1 Ribosomal protein S4/S9 N-terminal domain S4 PF01479.25 CCF51802.1 - 2.6e-11 43.1 0.0 4.3e-11 42.3 0.0 1.4 1 0 0 1 1 1 1 S4 domain UCH PF00443.29 CCF51803.1 - 4.8e-45 154.0 0.0 6.4e-45 153.7 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 CCF51803.1 - 1.1e-10 41.7 7.4 2.3e-09 37.3 7.4 2.4 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase ubiquitin PF00240.23 CCF51803.1 - 7.2e-09 35.3 0.0 1.5e-08 34.2 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family GTP_EFTU PF00009.27 CCF51805.1 - 1.7e-26 93.0 9.6 2.5e-26 92.4 2.6 3.3 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain IF-2 PF11987.8 CCF51805.1 - 2.7e-24 85.3 0.2 5.4e-24 84.3 0.2 1.5 1 0 0 1 1 1 1 Translation-initiation factor 2 MMR_HSR1 PF01926.23 CCF51805.1 - 2.6e-06 27.5 0.2 5.3e-06 26.5 0.2 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D2 PF03144.25 CCF51805.1 - 0.0039 17.6 0.5 0.18 12.2 0.2 2.8 2 0 0 2 2 2 1 Elongation factor Tu domain 2 FeoB_N PF02421.18 CCF51805.1 - 0.0063 16.1 0.1 0.033 13.7 0.1 2.2 1 1 0 1 1 1 1 Ferrous iron transport protein B SRPRB PF09439.10 CCF51805.1 - 0.14 11.6 0.1 0.42 10.0 0.1 1.8 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit Cep57_MT_bd PF06657.13 CCF51806.1 - 0.26 11.8 28.6 3.2 8.3 1.2 4.8 3 0 0 3 3 3 0 Centrosome microtubule-binding domain of Cep57 DUF3138 PF11336.8 CCF51806.1 - 1.7 7.1 3.6 16 3.9 0.3 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3138) RRM_1 PF00076.22 CCF51807.1 - 4.8e-76 250.5 0.7 9.7e-19 67.0 0.0 5.7 5 0 0 5 5 5 5 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 CCF51807.1 - 5.2e-07 29.3 0.0 0.0084 15.7 0.0 4.4 4 1 1 5 5 5 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 CCF51807.1 - 2.2e-06 27.4 0.0 1.2 9.0 0.0 4.7 5 0 0 5 5 5 2 Occluded RNA-recognition motif Nup35_RRM_2 PF14605.6 CCF51807.1 - 6.2e-06 26.1 0.0 1.9 8.6 0.0 4.1 4 0 0 4 4 4 2 Nup53/35/40-type RNA recognition motif RRM_2 PF04059.12 CCF51807.1 - 6.8e-05 23.0 0.0 1.2 9.4 0.0 4.2 4 0 0 4 4 4 1 RNA recognition motif 2 RRM_7 PF16367.5 CCF51807.1 - 0.00037 20.6 0.2 1.8 8.7 0.0 5.0 5 1 0 5 5 5 1 RNA recognition motif Limkain-b1 PF11608.8 CCF51807.1 - 0.0089 16.1 0.2 0.42 10.7 0.0 3.7 4 0 0 4 4 4 1 Limkain b1 DUF89 PF01937.19 CCF51808.1 - 3.5e-110 368.3 0.1 4e-110 368.1 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF89 polyprenyl_synt PF00348.17 CCF51808.1 - 0.13 11.3 0.0 0.2 10.7 0.0 1.2 1 0 0 1 1 1 0 Polyprenyl synthetase 2OG-FeII_Oxy_2 PF13532.6 CCF51810.1 - 3.3e-14 53.5 0.0 5.5e-14 52.8 0.0 1.4 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily RINGv PF12906.7 CCF51811.1 - 1.6e-06 28.2 5.7 5e-06 26.5 5.7 1.8 1 1 0 1 1 1 1 RING-variant domain DUF3797 PF12677.7 CCF51811.1 - 0.0031 17.4 0.4 0.3 11.0 0.0 2.6 3 0 0 3 3 3 1 Domain of unknown function (DUF3797) FANCL_C PF11793.8 CCF51811.1 - 0.066 13.4 3.0 0.13 12.5 3.0 1.4 1 0 0 1 1 1 0 FANCL C-terminal domain zf-RING_4 PF14570.6 CCF51811.1 - 0.36 10.6 2.7 0.75 9.6 2.7 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain SPX PF03105.19 CCF51811.1 - 0.63 9.9 3.6 1.1 9.1 3.6 1.3 1 0 0 1 1 1 0 SPX domain zf-C3HC4 PF00097.25 CCF51811.1 - 1 9.3 5.2 2.1 8.3 5.2 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 CCF51811.1 - 3.3 7.4 8.1 0.3 10.7 3.0 1.9 2 1 0 2 2 2 0 Zinc-ribbon, C4HC2 type PHD_4 PF16866.5 CCF51811.1 - 3.5 7.8 5.7 7.2 6.8 5.7 1.5 1 0 0 1 1 1 0 PHD-finger SRP9-21 PF05486.12 CCF51812.1 - 3.6e-08 33.7 7.7 5.9e-08 33.0 0.6 2.9 2 2 0 2 2 2 1 Signal recognition particle 9 kDa protein (SRP9) Med3 PF11593.8 CCF51812.1 - 1 8.5 12.5 1.1 8.3 12.5 1.0 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Mito_carr PF00153.27 CCF51813.1 - 1.3e-61 204.5 4.2 1.1e-21 76.6 0.2 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Fucose_iso_C PF02952.17 CCF51813.1 - 0.14 11.9 0.1 0.26 11.0 0.1 1.5 1 0 0 1 1 1 0 L-fucose isomerase, C-terminal domain HMG_box PF00505.19 CCF51814.1 - 1.1e-24 86.6 0.4 1.5e-24 86.2 0.4 1.2 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 CCF51814.1 - 1.2e-18 67.4 0.8 2.1e-18 66.6 0.8 1.4 1 0 0 1 1 1 1 HMG-box domain YABBY PF04690.13 CCF51814.1 - 0.0071 16.9 0.2 0.0071 16.9 0.2 1.4 2 0 0 2 2 2 1 YABBY protein CHDNT PF08073.12 CCF51814.1 - 0.0088 16.0 0.0 0.013 15.4 0.0 1.2 1 0 0 1 1 1 1 CHDNT (NUC034) domain RR_TM4-6 PF06459.12 CCF51814.1 - 0.06 13.2 2.4 0.086 12.7 2.4 1.3 1 1 0 1 1 1 0 Ryanodine Receptor TM 4-6 PS_Dcarbxylase PF02666.15 CCF51815.1 - 2.6e-46 157.7 0.0 3.9e-46 157.1 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase AAA_12 PF13087.6 CCF51816.1 - 2.1e-57 194.0 0.0 3.5e-57 193.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 CCF51816.1 - 2.4e-42 145.5 1.7 3.7e-42 144.9 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 CCF51816.1 - 1.5e-14 54.5 0.0 7.8e-14 52.2 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 CCF51816.1 - 1.3e-12 47.8 0.0 2.7e-08 33.8 0.0 2.9 1 1 1 2 2 2 2 AAA domain UvrD-helicase PF00580.21 CCF51816.1 - 0.0012 18.5 0.1 0.0086 15.6 0.0 2.4 3 0 0 3 3 3 1 UvrD/REP helicase N-terminal domain Viral_helicase1 PF01443.18 CCF51816.1 - 0.0028 17.4 0.0 9.8 5.8 0.0 3.3 2 1 0 3 3 3 1 Viral (Superfamily 1) RNA helicase ResIII PF04851.15 CCF51816.1 - 0.0037 17.3 0.0 0.011 15.8 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit PhoH PF02562.16 CCF51816.1 - 0.0041 16.6 0.1 0.011 15.3 0.0 1.6 2 0 0 2 2 2 1 PhoH-like protein Rad17 PF03215.15 CCF51816.1 - 0.09 12.7 0.0 0.16 11.9 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_7 PF12775.7 CCF51816.1 - 0.1 12.1 0.0 0.19 11.2 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_16 PF13191.6 CCF51816.1 - 0.11 12.9 0.6 0.35 11.2 0.0 2.2 2 1 0 2 2 2 0 AAA ATPase domain AAA_22 PF13401.6 CCF51816.1 - 0.12 12.7 0.0 0.82 9.9 0.0 2.3 2 0 0 2 2 2 0 AAA domain DUF4140 PF13600.6 CCF51816.1 - 0.63 10.5 4.5 13 6.3 1.2 3.4 3 0 0 3 3 3 0 N-terminal domain of unknown function (DUF4140) IATP PF04568.12 CCF51817.1 - 4.6e-13 49.4 1.0 5.2e-13 49.2 1.0 1.1 1 0 0 1 1 1 1 Mitochondrial ATPase inhibitor, IATP MOFRL PF05161.13 CCF51817.1 - 0.0036 17.5 0.3 0.0048 17.1 0.3 1.4 1 1 0 1 1 1 1 MOFRL family UPF0449 PF15136.6 CCF51817.1 - 0.0052 17.2 0.8 0.0065 16.9 0.8 1.1 1 0 0 1 1 1 1 Uncharacterised protein family UPF0449 DUF1366 PF07104.11 CCF51817.1 - 0.077 12.7 2.6 0.11 12.2 2.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1366) DUF4140 PF13600.6 CCF51817.1 - 0.12 12.9 2.7 0.17 12.4 2.7 1.3 1 0 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) DUF1003 PF06210.11 CCF51817.1 - 0.53 10.4 2.8 0.74 9.9 2.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1003) ATP_sub_h PF10775.9 CCF51818.1 - 3.3e-23 81.4 2.0 4.8e-23 80.9 2.0 1.3 1 0 0 1 1 1 1 ATP synthase complex subunit h eIF2_C PF09173.11 CCF51819.1 - 8.6e-37 125.3 0.2 2.3e-36 123.9 0.2 1.8 1 0 0 1 1 1 1 Initiation factor eIF2 gamma, C terminal GTP_EFTU PF00009.27 CCF51819.1 - 1.4e-21 76.9 0.9 9.1e-21 74.3 0.9 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 CCF51819.1 - 2.1e-13 50.5 0.4 2.1e-13 50.5 0.4 2.2 3 0 0 3 3 3 1 Elongation factor Tu domain 2 RsgA_GTPase PF03193.16 CCF51819.1 - 0.00068 19.6 0.4 0.029 14.3 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase MMR_HSR1 PF01926.23 CCF51819.1 - 0.0047 17.0 0.0 0.011 15.8 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase MMR_HSR1_Xtn PF16897.5 CCF51819.1 - 0.012 15.7 0.8 0.054 13.5 0.1 2.3 2 0 0 2 2 2 0 C-terminal region of MMR_HSR1 domain Dynamin_N PF00350.23 CCF51819.1 - 0.092 12.8 0.2 0.22 11.5 0.2 1.9 1 1 0 1 1 1 0 Dynamin family muHD PF10291.9 CCF51820.1 - 8.2e-62 209.0 0.0 1.2e-61 208.5 0.0 1.2 1 0 0 1 1 1 1 Muniscin C-terminal mu homology domain FCH PF00611.23 CCF51820.1 - 1.7e-08 34.6 1.9 2.3e-08 34.2 0.0 2.2 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain Pkinase PF00069.25 CCF51821.1 - 4e-67 226.4 0.0 5e-67 226.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF51821.1 - 2.8e-32 112.0 0.0 3.6e-32 111.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 CCF51821.1 - 1.2e-05 24.5 0.1 1.6e-05 24.0 0.1 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 CCF51821.1 - 0.00041 19.8 0.0 0.0011 18.3 0.0 1.7 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CCF51821.1 - 0.00068 19.6 0.0 0.0012 18.8 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kinase-like PF14531.6 CCF51821.1 - 0.0066 15.8 0.0 0.041 13.2 0.0 2.0 1 1 1 2 2 2 1 Kinase-like FTA2 PF13095.6 CCF51821.1 - 0.014 15.1 0.0 0.022 14.4 0.0 1.3 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 RIO1 PF01163.22 CCF51821.1 - 0.017 14.7 0.0 0.054 13.1 0.0 1.7 2 0 0 2 2 2 0 RIO1 family Glyco_hydro_35 PF01301.19 CCF51822.1 - 2.1e-75 254.3 0.0 3.5e-75 253.6 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 35 BetaGal_dom4_5 PF13364.6 CCF51822.1 - 9.7e-49 164.7 3.0 4.3e-29 101.4 0.1 3.4 3 0 0 3 3 3 2 Beta-galactosidase jelly roll domain BetaGal_dom2 PF10435.9 CCF51822.1 - 3.5e-09 36.7 1.0 3.5e-09 36.7 1.0 2.1 2 0 0 2 2 2 1 Beta-galactosidase, domain 2 Cellulase PF00150.18 CCF51822.1 - 0.0016 17.9 0.0 0.004 16.6 0.0 1.7 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) BetaGal_dom3 PF13363.6 CCF51822.1 - 0.0044 16.6 0.0 0.0097 15.5 0.0 1.6 1 0 0 1 1 1 1 Beta-galactosidase, domain 3 LSM PF01423.22 CCF51823.1 - 3.7e-20 71.4 0.3 4.7e-20 71.0 0.3 1.2 1 0 0 1 1 1 1 LSM domain DNA_repr_REX1B PF14966.6 CCF51824.1 - 5.5e-07 30.2 2.1 0.028 15.1 0.3 2.8 3 0 0 3 3 3 2 DNA repair REX1-B DUF4618 PF15397.6 CCF51824.1 - 0.0011 18.4 3.3 0.0016 17.9 3.3 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4618) PKcGMP_CC PF16808.5 CCF51824.1 - 0.01 15.7 0.9 0.03 14.2 0.9 1.7 1 0 0 1 1 1 1 Coiled-coil N-terminus of cGMP-dependent protein kinase LEH PF07858.12 CCF51824.1 - 0.015 15.4 0.0 0.033 14.3 0.0 1.5 1 0 0 1 1 1 0 Limonene-1,2-epoxide hydrolase catalytic domain TSC22 PF01166.18 CCF51824.1 - 0.12 12.7 5.8 7.1 7.0 0.1 2.6 2 0 0 2 2 2 0 TSC-22/dip/bun family GAT PF03127.14 CCF51824.1 - 0.14 12.5 3.0 0.19 12.1 0.7 2.3 1 1 2 3 3 3 0 GAT domain S4 PF01479.25 CCF51825.1 - 1.7e-10 40.5 1.2 1.7e-10 40.5 1.2 3.2 4 0 0 4 4 4 1 S4 domain Ribosomal_S4 PF00163.19 CCF51825.1 - 4.5e-06 27.5 0.1 9.5e-06 26.4 0.1 1.6 1 1 0 1 1 1 1 Ribosomal protein S4/S9 N-terminal domain Ribosomal_L21e PF01157.18 CCF51826.1 - 4.7e-45 151.6 3.6 5.5e-45 151.4 2.5 1.6 2 0 0 2 2 2 1 Ribosomal protein L21e DUF3987 PF13148.6 CCF51826.1 - 0.084 11.9 0.7 0.11 11.6 0.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) Mito_carr PF00153.27 CCF51827.1 - 2.8e-73 241.9 3.1 6e-25 87.0 0.0 3.5 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 CCF51827.1 - 0.0089 15.2 5.2 0.24 10.5 0.1 3.7 2 1 2 4 4 4 2 Gammaproteobacterial serine protease Cpn60_TCP1 PF00118.24 CCF51828.1 - 8.9e-164 545.7 5.3 1e-163 545.5 5.3 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Got1 PF04178.12 CCF51829.1 - 1.9e-31 108.8 10.0 2.7e-31 108.3 10.0 1.2 1 0 0 1 1 1 1 Got1/Sft2-like family Erythrovirus_X PF06795.11 CCF51829.1 - 0.13 12.6 0.1 0.27 11.6 0.1 1.5 1 0 0 1 1 1 0 Erythrovirus X protein DUF2070 PF09843.9 CCF51829.1 - 0.16 10.3 4.1 0.17 10.1 4.1 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) DUF4396 PF14342.6 CCF51829.1 - 0.45 10.9 3.8 0.65 10.4 3.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4396) zf-primase PF09329.11 CCF51830.1 - 4.7e-11 42.3 2.2 9.2e-11 41.4 2.2 1.5 1 0 0 1 1 1 1 Primase zinc finger Sigma_reg_N PF13800.6 CCF51831.1 - 0.14 12.5 0.7 0.29 11.4 0.4 1.7 1 1 0 1 1 1 0 Sigma factor regulator N-terminal RNase_P_p30 PF01876.16 CCF51832.1 - 2.9e-59 200.1 0.0 1.4e-58 197.9 0.0 2.1 1 1 0 1 1 1 1 RNase P subunit p30 Hamartin PF04388.12 CCF51832.1 - 0.82 8.3 6.0 0.073 11.7 1.7 1.3 2 0 0 2 2 2 0 Hamartin protein adh_short PF00106.25 CCF51833.1 - 7.2e-33 113.7 0.1 9.5e-33 113.3 0.1 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF51833.1 - 1.1e-22 80.7 0.1 2.8e-22 79.4 0.1 1.5 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF51833.1 - 1.2e-08 35.1 0.4 3.3e-08 33.7 0.4 1.6 1 1 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 CCF51833.1 - 0.05 13.5 0.1 0.09 12.7 0.1 1.4 1 0 0 1 1 1 0 NAD(P)H-binding Abhydrolase_3 PF07859.13 CCF51835.1 - 1.4e-33 116.5 0.0 1.7e-33 116.2 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 CCF51835.1 - 2e-07 30.7 0.0 1.1e-06 28.2 0.0 1.9 1 1 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_6 PF12697.7 CCF51835.1 - 0.00021 22.0 1.6 0.00038 21.1 1.5 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 CCF51835.1 - 0.00032 20.4 0.0 0.0005 19.8 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold AXE1 PF05448.12 CCF51835.1 - 0.00098 17.9 0.0 0.0015 17.3 0.0 1.2 1 0 0 1 1 1 1 Acetyl xylan esterase (AXE1) DLH PF01738.18 CCF51835.1 - 0.0023 17.5 0.0 0.085 12.4 0.0 2.1 2 0 0 2 2 2 1 Dienelactone hydrolase family Abhydrolase_2 PF02230.16 CCF51835.1 - 0.0072 16.1 0.0 0.011 15.5 0.0 1.2 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase DUF2974 PF11187.8 CCF51835.1 - 0.012 15.2 0.0 0.017 14.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) BAAT_C PF08840.11 CCF51835.1 - 0.023 14.6 0.0 0.061 13.2 0.0 1.6 1 1 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal UPF0227 PF05728.12 CCF51835.1 - 0.064 13.2 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0227) Esterase_phd PF10503.9 CCF51835.1 - 0.069 12.6 0.0 0.11 12.0 0.0 1.2 1 0 0 1 1 1 0 Esterase PHB depolymerase MIP PF00230.20 CCF51836.1 - 1.4e-45 155.7 4.3 1.9e-45 155.3 4.3 1.2 1 0 0 1 1 1 1 Major intrinsic protein Collagen PF01391.18 CCF51836.1 - 0.0027 17.4 9.0 0.0089 15.8 9.0 1.9 1 0 0 1 1 1 1 Collagen triple helix repeat (20 copies) HSP90 PF00183.18 CCF51837.1 - 1.6e-222 740.0 26.8 2e-222 739.7 26.8 1.0 1 0 0 1 1 1 1 Hsp90 protein HATPase_c PF02518.26 CCF51837.1 - 7.1e-15 55.5 0.1 1.3e-14 54.6 0.1 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 CCF51837.1 - 7.1e-11 42.1 0.1 2.2e-10 40.5 0.1 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Cofac_haem_bdg PF04187.13 CCF51837.1 - 0.055 13.5 0.5 0.25 11.3 0.0 2.3 2 1 1 3 3 3 0 Haem-binding uptake, Tiki superfamily, ChaN Peptidase_C37 PF05416.12 CCF51837.1 - 1.8 7.0 9.2 0.72 8.3 0.1 2.2 2 0 0 2 2 2 0 Southampton virus-type processing peptidase Exo_endo_phos PF03372.23 CCF51838.1 - 1.1e-22 80.7 0.1 6e-22 78.3 0.1 2.0 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family LRR_8 PF13855.6 CCF51838.1 - 1.3e-11 44.1 13.6 8.2e-08 31.9 4.5 2.5 1 1 1 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 CCF51838.1 - 1.7e-09 37.8 6.7 0.00015 22.1 0.6 2.7 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 CCF51838.1 - 2.3 9.1 4.9 1.3e+02 3.7 0.2 4.6 3 1 1 4 4 4 0 Leucine Rich Repeat Pkinase PF00069.25 CCF51839.1 - 2e-59 201.1 0.0 8.5e-59 199.1 0.0 1.8 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF51839.1 - 1.5e-27 96.6 0.0 1.7e-26 93.0 0.0 2.2 2 0 0 2 2 2 1 Protein tyrosine kinase Haspin_kinase PF12330.8 CCF51839.1 - 0.0033 16.4 0.1 0.0033 16.4 0.1 1.7 2 0 0 2 2 2 1 Haspin like kinase domain Kinase-like PF14531.6 CCF51839.1 - 0.0042 16.4 0.0 0.0042 16.4 0.0 1.6 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 CCF51839.1 - 0.041 13.8 1.7 0.22 11.4 0.0 2.3 2 0 0 2 2 2 0 Phosphotransferase enzyme family SLATT_1 PF18181.1 CCF51840.1 - 0.00091 19.1 3.0 0.047 13.6 0.0 2.8 3 0 0 3 3 3 2 SMODS and SLOG-associating 2TM effector domain 1 KR PF08659.10 CCF51840.1 - 0.12 12.2 0.0 0.27 11.1 0.0 1.5 1 0 0 1 1 1 0 KR domain SMC_N PF02463.19 CCF51841.1 - 1.7e-70 236.9 12.5 3.8e-69 232.5 12.5 2.6 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 CCF51841.1 - 4.2e-23 81.9 0.0 1.5e-22 80.1 0.0 2.0 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 CCF51841.1 - 1.4e-09 38.2 12.3 2.2e-05 24.4 0.1 3.6 3 1 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 CCF51841.1 - 0.00087 19.8 29.4 0.00087 19.8 29.4 7.5 3 2 2 5 5 5 1 AAA domain AAA_29 PF13555.6 CCF51841.1 - 0.0017 18.0 0.0 0.0035 17.0 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain ABC_tran PF00005.27 CCF51841.1 - 2.2 8.8 19.7 2.2 8.8 0.0 6.0 4 2 0 4 4 4 0 ABC transporter DUF3573 PF12097.8 CCF51841.1 - 4.3 6.1 7.3 0.69 8.7 0.8 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF3573) Peroxin-13_N PF04088.13 CCF51844.1 - 2.7e-47 160.7 0.1 2.7e-47 160.7 0.1 1.5 2 0 0 2 2 2 1 Peroxin 13, N-terminal region SH3_1 PF00018.28 CCF51844.1 - 2.9e-12 46.0 0.0 6.1e-12 45.0 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 CCF51844.1 - 7.6e-11 41.7 0.0 1.4e-10 40.9 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 CCF51844.1 - 1.1e-10 41.1 0.0 1.9e-10 40.2 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain Pex2_Pex12 PF04757.14 CCF51844.1 - 0.059 13.0 0.0 0.082 12.5 0.0 1.2 1 0 0 1 1 1 0 Pex2 / Pex12 amino terminal region zf-RING_2 PF13639.6 CCF51845.1 - 1.3e-08 35.0 3.9 2.3e-08 34.3 3.9 1.4 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 CCF51845.1 - 2.7e-06 27.2 4.3 4.4e-06 26.5 4.3 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 CCF51845.1 - 0.00011 22.0 4.1 0.00017 21.4 4.1 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 CCF51845.1 - 0.00024 20.9 2.8 0.00039 20.2 2.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 CCF51845.1 - 0.00043 20.0 2.9 0.0008 19.1 2.9 1.4 1 0 0 1 1 1 1 RING-like zinc finger Zn_ribbon_17 PF17120.5 CCF51845.1 - 0.0012 18.4 2.7 0.0021 17.6 2.7 1.3 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-C3HC4 PF00097.25 CCF51845.1 - 0.0076 16.1 2.6 0.013 15.4 2.6 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CCF51845.1 - 0.18 11.9 1.8 0.38 10.8 1.8 1.5 1 0 0 1 1 1 0 RING-type zinc-finger zf-rbx1 PF12678.7 CCF51845.1 - 0.7 10.2 2.7 1.5 9.2 2.7 1.6 1 0 0 1 1 1 0 RING-H2 zinc finger domain DAHP_synth_1 PF00793.20 CCF51846.1 - 3.1e-98 328.0 0.0 3.9e-98 327.7 0.0 1.0 1 0 0 1 1 1 1 DAHP synthetase I family CBFD_NFYB_HMF PF00808.23 CCF51847.1 - 1.1e-17 64.0 0.1 2.2e-17 63.1 0.1 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 CCF51847.1 - 0.041 14.2 0.3 0.19 12.1 0.0 1.8 2 0 0 2 2 2 0 Core histone H2A/H2B/H3/H4 ECH_1 PF00378.20 CCF51848.1 - 1.6e-47 161.9 0.0 2.1e-47 161.5 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 CCF51848.1 - 7.1e-22 78.3 0.5 1.3e-21 77.5 0.4 1.4 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase DUF2138 PF09909.9 CCF51848.1 - 0.065 11.5 0.0 0.098 11.0 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2138) Kinesin PF00225.23 CCF51849.1 - 9.4e-100 333.8 0.0 7.6e-54 182.9 0.0 3.0 2 0 0 2 2 2 2 Kinesin motor domain Microtub_bd PF16796.5 CCF51849.1 - 4.2e-25 88.4 0.0 1.4e-24 86.8 0.0 1.9 1 0 0 1 1 1 1 Microtubule binding TMF_DNA_bd PF12329.8 CCF51849.1 - 0.0023 17.9 5.1 0.0023 17.9 5.1 13.7 13 3 2 15 15 15 2 TATA element modulatory factor 1 DNA binding SMN PF06003.12 CCF51849.1 - 0.22 10.7 5.1 0.5 9.6 1.4 3.2 2 0 0 2 2 2 0 Survival motor neuron protein (SMN) SH3_1 PF00018.28 CCF51850.1 - 6.9e-12 44.8 0.1 1.3e-11 43.9 0.1 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 CCF51850.1 - 1.4e-08 34.5 0.0 2.5e-08 33.6 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 CCF51850.1 - 2.6e-08 33.4 0.0 5.7e-08 32.3 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_10 PF17902.1 CCF51850.1 - 0.0023 18.0 0.0 0.0039 17.2 0.0 1.3 1 0 0 1 1 1 1 SH3 domain Bac_rhodopsin PF01036.18 CCF51850.1 - 0.0055 16.3 10.0 0.0082 15.7 10.0 1.2 1 0 0 1 1 1 1 Bacteriorhodopsin-like protein SH3_3 PF08239.11 CCF51850.1 - 0.05 13.9 0.1 0.11 12.8 0.1 1.6 1 0 0 1 1 1 0 Bacterial SH3 domain Phage_holin_1 PF04531.13 CCF51850.1 - 0.12 13.0 0.3 0.12 13.0 0.3 1.9 2 0 0 2 2 2 0 Bacteriophage holin L51_S25_CI-B8 PF05047.16 CCF51851.1 - 0.0006 19.7 0.0 0.00089 19.1 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain Lysine_decarbox PF03641.14 CCF51855.1 - 9.3e-31 106.7 0.1 1.8e-30 105.8 0.1 1.4 1 0 0 1 1 1 1 Possible lysine decarboxylase ABC_tran PF00005.27 CCF51855.1 - 2.9e-14 53.8 0.0 1.2e-13 51.7 0.0 2.1 1 1 0 1 1 1 1 ABC transporter LDcluster4 PF18306.1 CCF51855.1 - 4e-10 39.5 3.0 1.2e-09 37.9 3.0 1.8 1 1 0 1 1 1 1 SLOG cluster4 family AAA_21 PF13304.6 CCF51855.1 - 3.4e-07 30.4 4.5 0.0026 17.6 0.6 2.2 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 CCF51855.1 - 0.00089 19.0 0.0 0.0023 17.7 0.0 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_25 PF13481.6 CCF51855.1 - 0.0037 16.9 0.0 0.0063 16.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CCF51855.1 - 0.0085 16.5 0.0 0.018 15.5 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA_15 PF13175.6 CCF51855.1 - 0.028 14.1 0.0 0.04 13.6 0.0 1.1 1 0 0 1 1 1 0 AAA ATPase domain AAA_28 PF13521.6 CCF51855.1 - 0.036 14.3 0.0 0.079 13.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain SMC_N PF02463.19 CCF51855.1 - 0.038 13.4 0.1 9.6 5.6 0.0 2.2 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 CCF51855.1 - 0.046 13.6 0.0 0.096 12.6 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase MMR_HSR1 PF01926.23 CCF51855.1 - 0.056 13.5 0.1 0.14 12.2 0.1 1.8 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_23 PF13476.6 CCF51855.1 - 0.075 13.5 0.0 0.13 12.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_27 PF13514.6 CCF51855.1 - 0.087 12.4 0.4 3 7.4 0.0 2.6 3 0 0 3 3 3 0 AAA domain Sigma54_activat PF00158.26 CCF51855.1 - 0.11 12.2 0.1 10 5.8 0.1 2.9 3 0 0 3 3 3 0 Sigma-54 interaction domain DUF815 PF05673.13 CCF51855.1 - 0.13 11.4 0.1 0.22 10.6 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF815) UAA PF08449.11 CCF51856.1 - 1.1e-46 159.5 6.7 9.7e-46 156.3 5.2 2.0 2 0 0 2 2 2 1 UAA transporter family EamA PF00892.20 CCF51856.1 - 2.3e-12 47.3 22.6 2.2e-08 34.3 7.2 4.3 4 1 0 4 4 4 2 EamA-like transporter family Nuc_sug_transp PF04142.15 CCF51856.1 - 2.5e-06 26.9 0.7 0.016 14.4 0.1 2.3 2 0 0 2 2 2 2 Nucleotide-sugar transporter TPT PF03151.16 CCF51856.1 - 3.6e-06 26.5 7.9 0.00041 19.8 1.1 2.6 3 0 0 3 3 3 2 Triose-phosphate Transporter family PUNUT PF16913.5 CCF51856.1 - 1.1e-05 24.8 7.3 0.00013 21.3 8.8 1.8 1 1 0 1 1 1 1 Purine nucleobase transmembrane transport TMEM234 PF10639.9 CCF51856.1 - 0.01 15.8 5.2 0.19 11.8 0.2 2.6 2 0 0 2 2 2 0 Putative transmembrane family 234 CRT-like PF08627.10 CCF51856.1 - 0.047 12.6 12.1 0.072 12.0 0.6 2.7 2 1 0 3 3 3 0 CRT-like, chloroquine-resistance transporter-like TPR_10 PF13374.6 CCF51857.1 - 0.062 13.2 2.5 0.75 9.7 0.2 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_4 PF07721.14 CCF51857.1 - 0.079 13.6 0.9 0.33 11.7 0.9 2.2 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_7 PF13176.6 CCF51857.1 - 0.081 13.0 0.2 0.52 10.5 0.1 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_MalT PF17874.1 CCF51857.1 - 0.082 12.3 6.5 1.3 8.3 0.0 2.6 2 1 1 3 3 3 0 MalT-like TPR region TPR_12 PF13424.6 CCF51857.1 - 0.095 13.0 1.5 1.6 9.1 0.1 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 CCF51857.1 - 0.11 12.8 1.8 2.2 8.7 0.0 3.3 4 0 0 4 4 4 0 Tetratricopeptide repeat Adaptin_N PF01602.20 CCF51858.1 - 1.4e-98 330.7 0.0 5.3e-98 328.8 0.0 1.9 1 1 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 CCF51858.1 - 8.2e-12 45.5 1.1 1.5e-09 38.1 0.0 2.7 3 0 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 CCF51858.1 - 0.00028 21.2 4.3 0.22 11.9 0.3 3.5 3 0 0 3 3 3 2 HEAT repeats HEAT PF02985.22 CCF51858.1 - 0.033 14.4 2.0 39 4.9 0.0 5.1 5 0 0 5 5 5 0 HEAT repeat DUF3108 PF11306.8 CCF51858.1 - 0.054 13.5 0.3 0.11 12.5 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3108) Proteasom_PSMB PF10508.9 CCF51858.1 - 0.11 11.0 0.6 3.5 6.0 0.0 2.3 2 0 0 2 2 2 0 Proteasome non-ATPase 26S subunit Tim54 PF11711.8 CCF51859.1 - 3.7e-50 170.8 0.0 3.7e-50 170.8 0.0 2.9 2 1 1 3 3 3 1 Inner membrane protein import complex subunit Tim54 HNOBA PF07701.14 CCF51859.1 - 0.11 11.9 3.6 0.44 10.0 2.8 2.1 2 0 0 2 2 2 0 Heme NO binding associated GREB1 PF15782.5 CCF51859.1 - 0.38 7.8 3.1 0.63 7.1 3.1 1.2 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer MID_MedPIWI PF18296.1 CCF51859.1 - 1.4 8.6 11.4 0.27 11.0 4.0 2.7 3 0 0 3 3 3 0 MID domain of medPIWI Secretin_N_2 PF07655.13 CCF51859.1 - 3.7 8.2 28.9 0.06 13.9 18.8 2.3 2 0 0 2 2 2 0 Secretin N-terminal domain RNase_PH PF01138.21 CCF51860.1 - 1.2e-26 93.7 0.1 2e-26 93.1 0.1 1.3 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 HGTP_anticodon PF03129.20 CCF51861.1 - 1.1e-20 73.5 0.1 6e-20 71.2 0.0 2.4 3 0 0 3 3 3 1 Anticodon binding domain tRNA-synt_2b PF00587.25 CCF51861.1 - 7.5e-10 39.1 0.3 2.7e-09 37.3 0.3 2.0 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) FMN_red PF03358.15 CCF51862.1 - 8.7e-09 35.3 0.0 1.2e-08 34.9 0.0 1.2 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 CCF51862.1 - 2.6e-06 27.3 0.0 6e-06 26.1 0.0 1.6 1 1 1 2 2 2 1 Flavodoxin-like fold Flavodoxin_1 PF00258.25 CCF51862.1 - 0.0045 17.2 0.2 0.16 12.2 0.2 2.3 1 1 0 1 1 1 1 Flavodoxin Flavodoxin_5 PF12724.7 CCF51862.1 - 0.027 14.7 0.2 1.3 9.3 0.0 2.2 1 1 1 2 2 2 0 Flavodoxin domain WD40 PF00400.32 CCF51863.1 - 3.5e-53 176.4 28.5 1.4e-10 41.5 0.2 8.5 7 2 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF51863.1 - 6.1e-14 52.1 1.7 2.4e-06 27.7 0.1 4.6 2 1 0 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 CCF51863.1 - 6.5e-10 38.3 10.9 0.0002 20.2 0.0 5.1 2 2 2 5 5 5 2 Nucleoporin Nup120/160 LisH_TPL PF17814.1 CCF51863.1 - 0.00054 19.6 0.0 0.0013 18.3 0.0 1.7 1 0 0 1 1 1 1 LisH-like dimerisation domain VID27 PF08553.10 CCF51863.1 - 0.0087 15.2 0.1 6.9 5.6 0.0 2.8 2 1 1 3 3 3 2 VID27 C-terminal WD40-like domain LisH PF08513.11 CCF51863.1 - 0.025 14.5 0.1 0.048 13.6 0.1 1.4 1 0 0 1 1 1 0 LisH NUDIX PF00293.28 CCF51864.1 - 8.6e-14 51.7 0.0 4.6e-12 46.1 0.0 2.2 2 0 0 2 2 2 2 NUDIX domain MIF4G_like PF09088.11 CCF51865.1 - 0.18 11.6 0.0 0.34 10.7 0.0 1.4 2 0 0 2 2 2 0 MIF4G like zf-C2H2 PF00096.26 CCF51866.1 - 9.2e-22 76.2 28.2 1.6e-05 25.1 0.9 5.1 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 CCF51866.1 - 6.3e-16 58.0 25.5 4.1e-08 33.3 0.1 5.3 4 1 1 5 5 5 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 CCF51866.1 - 9.7e-09 35.3 26.3 0.015 16.1 1.5 5.1 4 0 0 4 4 4 4 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 CCF51866.1 - 0.0012 19.1 1.4 0.39 11.1 0.0 4.0 4 0 0 4 4 4 1 Zinc-finger double-stranded RNA-binding IGPD PF00475.18 CCF51866.1 - 0.04 14.2 0.0 0.069 13.5 0.0 1.3 1 0 0 1 1 1 0 Imidazoleglycerol-phosphate dehydratase zf-MYST PF17772.1 CCF51866.1 - 0.082 12.5 2.4 7.1 6.3 0.1 3.2 3 1 0 3 3 3 0 MYST family zinc finger domain zf-H2C2_5 PF13909.6 CCF51866.1 - 0.82 9.5 13.8 13 5.6 0.1 4.6 4 0 0 4 4 4 0 C2H2-type zinc-finger domain IF-2B PF01008.17 CCF51867.1 - 7.2e-57 192.7 0.0 9.9e-57 192.3 0.0 1.1 1 0 0 1 1 1 1 Initiation factor 2 subunit family REC104 PF17378.2 CCF51867.1 - 0.13 12.1 0.0 0.24 11.2 0.0 1.4 1 0 0 1 1 1 0 Meiotic recombination protein REC104 DEAD PF00270.29 CCF51868.1 - 7.9e-49 165.8 0.1 2.5e-47 160.9 0.0 2.3 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CCF51868.1 - 3.8e-30 104.5 0.0 8.4e-29 100.2 0.0 2.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain UTP25 PF06862.12 CCF51868.1 - 0.02 13.7 0.8 2.9 6.6 0.0 3.6 3 1 1 4 4 4 0 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 Aminotran_3 PF00202.21 CCF51869.1 - 5.7e-123 410.6 0.0 6.7e-123 410.3 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.21 CCF51869.1 - 5.3e-05 22.6 0.0 7.5e-05 22.1 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II DUF2007 PF09413.10 CCF51869.1 - 0.008 16.3 0.1 4.6 7.5 0.0 2.4 2 0 0 2 2 2 2 Putative prokaryotic signal transducing protein Beta_elim_lyase PF01212.21 CCF51869.1 - 0.0098 15.2 0.0 0.029 13.7 0.0 1.6 1 1 0 1 1 1 1 Beta-eliminating lyase DUF3128 PF11326.8 CCF51870.1 - 4.6e-21 75.0 0.2 6.1e-21 74.6 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3128) zf-H2C2_2 PF13465.6 CCF51871.1 - 3.8e-22 77.7 17.9 6.6e-06 26.3 0.1 5.2 5 0 0 5 5 5 4 Zinc-finger double domain zf-C2H2 PF00096.26 CCF51871.1 - 2.7e-20 71.6 27.2 5.6e-06 26.5 2.1 4.5 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CCF51871.1 - 6.6e-09 35.9 24.4 0.019 15.8 1.4 4.4 4 0 0 4 4 4 4 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 CCF51871.1 - 0.00088 19.5 3.2 0.97 9.8 0.0 3.2 4 0 0 4 4 4 2 Zinc-finger double-stranded RNA-binding CDC45 PF02724.14 CCF51871.1 - 0.017 13.5 15.3 0.031 12.6 15.3 1.3 1 0 0 1 1 1 0 CDC45-like protein zf-met PF12874.7 CCF51871.1 - 0.021 15.2 9.1 0.44 11.0 0.2 3.8 4 0 0 4 4 3 0 Zinc-finger of C2H2 type Nop14 PF04147.12 CCF51871.1 - 0.023 12.9 18.8 0.034 12.4 18.8 1.1 1 0 0 1 1 1 0 Nop14-like family FOXP-CC PF16159.5 CCF51871.1 - 0.036 14.7 2.4 42 4.9 0.1 3.6 1 1 2 3 3 3 0 FOXP coiled-coil domain zf-TRAF PF02176.18 CCF51871.1 - 0.043 14.5 1.1 0.043 14.5 1.1 2.7 2 1 1 3 3 3 0 TRAF-type zinc finger zf-C2H2_6 PF13912.6 CCF51871.1 - 0.1 12.6 15.4 0.1 12.6 0.5 4.1 4 0 0 4 4 4 0 C2H2-type zinc finger Mpp10 PF04006.12 CCF51871.1 - 0.1 11.0 14.4 0.15 10.4 14.4 1.2 1 0 0 1 1 1 0 Mpp10 protein NOA36 PF06524.12 CCF51871.1 - 0.1 11.9 27.7 0.11 11.8 26.6 1.5 1 1 0 1 1 1 0 NOA36 protein DNA_pol_phi PF04931.13 CCF51871.1 - 0.32 9.0 24.8 0.45 8.6 24.8 1.1 1 0 0 1 1 1 0 DNA polymerase phi Cwf_Cwc_15 PF04889.12 CCF51871.1 - 0.33 10.7 18.8 0.89 9.2 18.8 1.7 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein SDA1 PF05285.12 CCF51871.1 - 1.4 8.3 22.8 3 7.2 22.8 1.5 1 0 0 1 1 1 0 SDA1 RNA_pol_3_Rpc31 PF11705.8 CCF51871.1 - 2.1 8.6 24.1 1.3 9.2 18.5 2.9 2 0 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 SAPS PF04499.15 CCF51871.1 - 4.7 5.9 6.2 0.57 8.9 2.2 1.4 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein zf-C2H2_11 PF16622.5 CCF51871.1 - 5.3 6.9 16.4 2.1 8.2 1.4 3.4 3 0 0 3 3 3 0 zinc-finger C2H2-type BUD22 PF09073.10 CCF51871.1 - 8.1 5.7 26.5 0.28 10.5 19.2 2.1 2 0 0 2 2 2 0 BUD22 FGGY_C PF02782.16 CCF51872.1 - 0.082 12.6 0.0 0.12 12.1 0.0 1.2 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, C-terminal domain Sel1 PF08238.12 CCF51873.1 - 3e-09 37.2 18.3 1.9e-07 31.5 0.1 4.9 5 0 0 5 5 5 3 Sel1 repeat TPR_2 PF07719.17 CCF51873.1 - 0.029 14.5 0.5 5.6 7.3 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat RRM_1 PF00076.22 CCF51874.1 - 0.013 15.3 0.0 0.021 14.6 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 CCF51874.1 - 0.034 14.0 0.1 0.087 12.7 0.1 1.7 1 1 0 1 1 1 0 Occluded RNA-recognition motif PRIMA1 PF16101.5 CCF51874.1 - 0.84 9.7 5.1 1.8 8.6 5.1 1.6 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 Fip1 PF05182.13 CCF51875.1 - 6e-19 67.3 1.4 1.4e-18 66.1 1.4 1.7 1 0 0 1 1 1 1 Fip1 motif PAS_9 PF13426.7 CCF51876.1 - 1.3e-22 80.0 0.0 3e-13 49.9 0.0 2.5 2 0 0 2 2 2 2 PAS domain PAS_3 PF08447.12 CCF51876.1 - 6.8e-16 58.3 0.0 2.4e-07 30.9 0.0 3.6 3 0 0 3 3 3 3 PAS fold PAS PF00989.25 CCF51876.1 - 4e-14 52.6 0.0 4.2e-10 39.6 0.0 3.3 2 1 0 2 2 2 2 PAS fold PAS_4 PF08448.10 CCF51876.1 - 1.7e-07 31.5 0.0 0.00018 21.8 0.0 3.0 3 0 0 3 3 3 2 PAS fold PAS_8 PF13188.7 CCF51876.1 - 8.8e-06 25.6 0.0 0.016 15.2 0.0 2.5 2 0 0 2 2 2 2 PAS domain PAS_11 PF14598.6 CCF51876.1 - 0.0088 16.2 0.0 0.02 15.0 0.0 1.5 1 0 0 1 1 1 1 PAS domain Adap_comp_sub PF00928.21 CCF51877.1 - 1.8e-82 276.6 0.0 2.4e-82 276.3 0.0 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 CCF51877.1 - 0.0022 18.0 0.9 0.004 17.1 0.9 1.5 1 0 0 1 1 1 1 Clathrin adaptor complex small chain muHD PF10291.9 CCF51877.1 - 0.05 13.0 0.1 0.08 12.4 0.1 1.3 1 0 0 1 1 1 0 Muniscin C-terminal mu homology domain LSM PF01423.22 CCF51878.1 - 2.1e-17 62.6 0.5 2.6e-17 62.3 0.5 1.1 1 0 0 1 1 1 1 LSM domain Gemin7 PF11095.8 CCF51878.1 - 0.15 12.0 0.0 0.21 11.5 0.0 1.2 1 0 0 1 1 1 0 Gem-associated protein 7 (Gemin7) DUF4826 PF16108.5 CCF51878.1 - 0.18 12.1 0.0 0.24 11.7 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4826) XPG_I PF00867.18 CCF51879.1 - 2.5e-22 79.0 0.1 6.4e-22 77.7 0.1 1.8 1 0 0 1 1 1 1 XPG I-region XPG_N PF00752.17 CCF51879.1 - 6.3e-21 74.7 0.0 1.5e-20 73.5 0.0 1.7 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I_2 PF12813.7 CCF51879.1 - 8.7e-05 22.1 0.0 0.00015 21.3 0.0 1.3 1 0 0 1 1 1 1 XPG domain containing TPR_14 PF13428.6 CCF51879.1 - 0.044 14.6 0.2 0.14 13.0 0.2 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat 5_3_exonuc PF01367.20 CCF51879.1 - 0.09 13.4 0.0 0.23 12.1 0.0 1.6 1 0 0 1 1 1 0 5'-3' exonuclease, C-terminal SAM fold TPR_2 PF07719.17 CCF51879.1 - 0.15 12.2 0.1 0.32 11.2 0.1 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat Glyco_transf_90 PF05686.12 CCF51880.1 - 1.5e-25 90.0 0.0 8.4e-25 87.5 0.0 2.2 1 1 0 1 1 1 1 Glycosyl transferase family 90 PXA PF02194.15 CCF51882.1 - 1.2e-43 149.2 1.9 1.7e-43 148.7 0.1 2.2 2 0 0 2 2 2 1 PXA domain Nexin_C PF08628.12 CCF51882.1 - 2.7e-28 98.8 0.0 8e-28 97.3 0.0 1.9 1 0 0 1 1 1 1 Sorting nexin C terminal PX PF00787.24 CCF51882.1 - 6.2e-14 52.0 0.0 2e-13 50.3 0.0 2.0 2 0 0 2 2 2 1 PX domain RGS PF00615.19 CCF51882.1 - 8.5e-09 35.7 0.1 2.5e-08 34.2 0.1 1.9 1 0 0 1 1 1 1 Regulator of G protein signaling domain FapA PF03961.13 CCF51882.1 - 0.0032 16.1 1.6 0.035 12.7 0.3 2.1 2 0 0 2 2 2 1 Flagellar Assembly Protein A Snapin_Pallidin PF14712.6 CCF51882.1 - 0.13 12.7 7.4 1.9 9.0 0.3 3.7 3 1 1 4 4 4 0 Snapin/Pallidin Lebercilin PF15619.6 CCF51882.1 - 0.26 10.9 9.2 1.2 8.7 0.9 2.6 2 0 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease CAML PF14963.6 CCF51882.1 - 0.57 10.3 2.6 1.4 9.0 0.4 2.5 3 0 0 3 3 3 0 Calcium signal-modulating cyclophilin ligand ABC_tran_CTD PF16326.5 CCF51882.1 - 2.8 8.3 10.2 1.8 8.9 4.9 3.2 2 1 0 2 2 2 0 ABC transporter C-terminal domain GAS PF13851.6 CCF51882.1 - 4.3 6.6 9.0 0.58 9.5 3.1 2.3 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding YlqD PF11068.8 CCF51882.1 - 8.4 6.8 9.7 1.3 9.4 5.1 2.0 2 0 0 2 2 2 0 YlqD protein Mog1 PF04603.12 CCF51884.1 - 4.5e-39 134.0 0.0 6.4e-39 133.5 0.0 1.2 1 0 0 1 1 1 1 Ran-interacting Mog1 protein Dicty_REP PF05086.12 CCF51884.1 - 0.23 9.4 0.8 0.23 9.4 0.8 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Sterol_MT_C PF08498.10 CCF51885.1 - 3e-28 97.9 0.9 4.9e-28 97.2 0.9 1.3 1 0 0 1 1 1 1 Sterol methyltransferase C-terminal Methyltransf_11 PF08241.12 CCF51885.1 - 7.8e-20 71.3 0.0 1.4e-19 70.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF51885.1 - 4.8e-19 68.7 0.0 6.8e-19 68.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF51885.1 - 5.2e-17 62.4 0.0 9.3e-17 61.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 CCF51885.1 - 8.9e-16 58.0 0.0 1.2e-15 57.6 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_23 PF13489.6 CCF51885.1 - 5e-14 52.5 0.0 7.2e-14 52.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF51885.1 - 8e-13 49.0 0.0 1.6e-12 48.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CCF51885.1 - 3.5e-08 33.1 0.0 5.7e-08 32.4 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family PCMT PF01135.19 CCF51885.1 - 0.00027 20.8 0.0 0.00041 20.1 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_3 PF01596.17 CCF51885.1 - 0.00034 19.8 0.0 0.00054 19.2 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase MTS PF05175.14 CCF51885.1 - 0.0013 18.3 0.0 0.0024 17.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain UPF0020 PF01170.18 CCF51885.1 - 0.0017 18.1 0.0 0.0027 17.4 0.0 1.3 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 MetW PF07021.12 CCF51885.1 - 0.003 17.2 0.0 0.0046 16.6 0.0 1.3 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_32 PF13679.6 CCF51885.1 - 0.0094 15.9 0.0 0.014 15.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_24 PF13578.6 CCF51885.1 - 0.017 16.1 0.1 0.12 13.4 0.0 2.4 3 0 0 3 3 3 0 Methyltransferase domain Methyltr_RsmB-F PF01189.17 CCF51885.1 - 0.034 13.8 0.0 0.05 13.2 0.0 1.3 1 0 0 1 1 1 0 16S rRNA methyltransferase RsmB/F PrmA PF06325.13 CCF51885.1 - 0.034 13.5 0.0 0.051 13.0 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_15 PF09445.10 CCF51885.1 - 0.046 13.3 0.1 0.073 12.6 0.1 1.3 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase Methyltransf_2 PF00891.18 CCF51885.1 - 0.067 12.5 0.0 0.097 12.0 0.0 1.3 1 0 0 1 1 1 0 O-methyltransferase domain RrnaAD PF00398.20 CCF51885.1 - 0.11 11.5 0.0 0.16 11.0 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase DHFR_1 PF00186.19 CCF51886.1 - 1.3e-30 106.2 0.0 4.2e-30 104.6 0.0 1.8 1 1 0 1 1 1 1 Dihydrofolate reductase RVT_2 PF07727.14 CCF51887.1 - 1.5e-08 34.6 0.1 1.8e-08 34.3 0.1 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) ERCC4 PF02732.15 CCF51888.1 - 1.7e-20 73.8 0.0 3.8e-20 72.7 0.0 1.6 1 0 0 1 1 1 1 ERCC4 domain HHH_5 PF14520.6 CCF51888.1 - 0.066 13.8 0.0 0.18 12.4 0.0 1.7 1 0 0 1 1 1 0 Helix-hairpin-helix domain ATP-synt_ab PF00006.25 CCF51889.1 - 5.2e-62 209.3 0.0 8.2e-62 208.6 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 CCF51889.1 - 4.4e-23 81.6 3.1 4.4e-23 81.6 3.1 2.2 3 0 0 3 3 3 1 ATP synthase alpha/beta family, beta-barrel domain NB-ARC PF00931.22 CCF51889.1 - 0.0041 16.3 0.5 0.016 14.4 0.1 1.9 2 0 0 2 2 2 1 NB-ARC domain ATPase_2 PF01637.18 CCF51889.1 - 0.0062 16.5 0.0 0.012 15.5 0.0 1.4 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea RsgA_GTPase PF03193.16 CCF51889.1 - 0.011 15.6 0.1 0.025 14.5 0.1 1.5 1 0 0 1 1 1 0 RsgA GTPase AAA_16 PF13191.6 CCF51889.1 - 0.028 14.8 0.5 0.087 13.2 0.1 2.0 2 1 0 2 2 2 0 AAA ATPase domain ATPase PF06745.13 CCF51889.1 - 0.045 13.1 0.2 0.084 12.2 0.2 1.4 1 0 0 1 1 1 0 KaiC AAA PF00004.29 CCF51889.1 - 0.05 14.0 0.0 0.34 11.3 0.0 2.3 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.6 CCF51889.1 - 0.078 13.3 0.9 0.34 11.2 0.2 2.1 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 CCF51889.1 - 0.082 12.8 0.0 0.18 11.7 0.0 1.5 1 0 0 1 1 1 0 NACHT domain RNA_helicase PF00910.22 CCF51889.1 - 0.2 12.1 0.0 0.41 11.0 0.0 1.5 1 0 0 1 1 1 0 RNA helicase Cyclin_N PF00134.23 CCF51891.1 - 2.1e-08 33.9 0.9 7.1e-08 32.2 0.9 1.8 1 1 0 1 1 1 1 Cyclin, N-terminal domain DsbC PF11412.8 CCF51891.1 - 0.062 13.4 0.1 0.5 10.4 0.0 2.3 3 0 0 3 3 3 0 Disulphide bond corrector protein DsbC DnaJ PF00226.31 CCF51892.1 - 1.9e-16 59.9 0.1 6.6e-16 58.2 0.0 2.0 2 0 0 2 2 2 1 DnaJ domain Vps54_N PF10475.9 CCF51892.1 - 0.077 12.3 0.0 0.12 11.7 0.0 1.2 1 0 0 1 1 1 0 Vacuolar-sorting protein 54, of GARP complex Cyclin_N PF00134.23 CCF51893.1 - 7.6e-12 45.1 0.0 7.8e-11 41.8 0.0 2.1 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 CCF51893.1 - 0.00072 19.6 0.5 0.13 12.3 0.0 2.6 2 1 0 3 3 3 2 Cyclin, C-terminal domain TFIIB PF00382.19 CCF51893.1 - 0.0032 17.5 0.1 0.011 15.7 0.0 2.0 1 1 0 1 1 1 1 Transcription factor TFIIB repeat TPT PF03151.16 CCF51894.1 - 8.6e-22 77.8 16.5 1.1e-21 77.5 16.5 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family Phage_tail_NK PF16532.5 CCF51894.1 - 0.13 11.9 0.2 0.27 10.8 0.2 1.4 1 0 0 1 1 1 0 Sf6-type phage tail needle knob or tip of some Caudovirales Helicase_C_2 PF13307.6 CCF51895.1 - 4.9e-55 186.3 0.0 1.6e-54 184.6 0.0 2.0 1 0 0 1 1 1 1 Helicase C-terminal domain DEAD_2 PF06733.15 CCF51895.1 - 8.1e-48 162.4 0.1 1.7e-47 161.3 0.1 1.6 1 0 0 1 1 1 1 DEAD_2 DEAD PF00270.29 CCF51895.1 - 0.03 14.1 0.0 0.59 9.9 0.0 2.6 2 0 0 2 2 2 0 DEAD/DEAH box helicase 2-oxoacid_dh PF00198.23 CCF51896.1 - 3.8e-55 186.9 0.0 6.3e-55 186.2 0.0 1.3 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 CCF51896.1 - 4.1e-18 65.0 0.1 8.1e-18 64.0 0.1 1.5 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.17 CCF51896.1 - 7.3e-16 58.2 1.0 2.1e-15 56.8 0.4 2.1 2 0 0 2 2 2 1 e3 binding domain Biotin_lipoyl_2 PF13533.6 CCF51896.1 - 0.0029 17.4 0.0 0.0069 16.2 0.0 1.6 1 0 0 1 1 1 1 Biotin-lipoyl like CCDC24 PF15669.5 CCF51896.1 - 0.025 14.4 1.8 0.061 13.2 1.8 1.6 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 24 family SIS PF01380.22 CCF51897.1 - 4e-62 207.9 0.1 3.7e-34 117.4 0.1 2.3 2 0 0 2 2 2 2 SIS domain GATase_6 PF13522.6 CCF51897.1 - 1.2e-14 54.6 0.0 2.9e-14 53.4 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.6 CCF51897.1 - 2.5e-11 43.5 0.0 4.8e-11 42.7 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_4 PF13230.6 CCF51897.1 - 0.0001 21.3 0.0 0.00018 20.5 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferases class-II BRCA-2_OB1 PF09103.10 CCF51898.1 - 9.8e-36 122.4 0.0 1.7e-35 121.7 0.0 1.4 1 0 0 1 1 1 1 BRCA2, oligonucleotide/oligosaccharide-binding, domain 1 BRCA-2_helical PF09169.10 CCF51898.1 - 3.1e-06 27.0 0.6 1.8e-05 24.5 0.5 2.1 2 0 0 2 2 2 1 BRCA2, helical BRCA2 PF00634.18 CCF51898.1 - 0.0012 18.5 0.0 0.0025 17.4 0.0 1.6 1 0 0 1 1 1 1 BRCA2 repeat FAM176 PF14851.6 CCF51899.1 - 0.065 12.9 0.3 0.77 9.4 0.4 2.0 2 0 0 2 2 2 0 FAM176 family OAD_gamma PF04277.13 CCF51899.1 - 0.65 10.6 7.2 19 5.9 0.0 2.4 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain LST1 PF05083.13 CCF51901.1 - 0.082 13.2 0.2 0.73 10.2 0.0 2.3 2 0 0 2 2 2 0 LST-1 protein RVT_2 PF07727.14 CCF51902.1 - 3.6e-45 154.5 0.5 6.6e-45 153.6 0.5 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Chitin_synth_2 PF03142.15 CCF51903.1 - 7.5e-238 790.4 0.3 9.9e-238 790.0 0.3 1.1 1 0 0 1 1 1 1 Chitin synthase Myosin_head PF00063.21 CCF51903.1 - 3.5e-128 428.7 0.0 5.7e-127 424.7 0.0 2.0 1 1 0 1 1 1 1 Myosin head (motor domain) DEK_C PF08766.11 CCF51903.1 - 1.8e-15 56.6 1.9 7.2e-15 54.6 1.3 2.4 3 0 0 3 3 3 1 DEK C terminal domain Glyco_trans_2_3 PF13632.6 CCF51903.1 - 3.1e-11 43.6 3.2 3.1e-11 43.6 3.2 2.0 2 0 0 2 2 2 1 Glycosyl transferase family group 2 Cyt-b5 PF00173.28 CCF51903.1 - 3.9e-11 43.0 0.0 3.8e-09 36.6 0.0 3.1 3 0 0 3 3 3 1 Cytochrome b5-like Heme/Steroid binding domain Glyco_tranf_2_3 PF13641.6 CCF51903.1 - 5.6e-09 36.2 0.0 1.4e-07 31.6 0.0 2.4 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 CCF51903.1 - 0.013 15.4 0.0 4.8 6.9 0.0 2.9 3 0 0 3 3 3 0 Glycosyl transferase family 2 TFIIF_alpha PF05793.12 CCF51904.1 - 5.1e-07 28.7 43.4 0.00017 20.4 35.0 3.3 3 1 0 3 3 3 2 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Mre11_DNA_bind PF04152.14 CCF51904.1 - 0.61 10.4 4.2 10 6.4 0.5 2.7 2 0 0 2 2 2 0 Mre11 DNA-binding presumed domain Thymidylate_kin PF02223.17 CCF51906.1 - 1.7e-45 155.0 0.0 3.4e-45 154.0 0.0 1.5 1 0 0 1 1 1 1 Thymidylate kinase AAA_28 PF13521.6 CCF51906.1 - 0.022 15.0 0.3 0.11 12.7 0.1 2.2 2 1 0 2 2 2 0 AAA domain DUF5543 PF17697.1 CCF51906.1 - 5.6 7.3 9.6 9.5 6.5 1.9 3.4 3 0 0 3 3 3 0 Family of unknown function (DUF5543) gag_pre-integrs PF13976.6 CCF51908.1 - 0.00026 20.8 3.1 0.00059 19.6 3.1 1.6 1 1 0 1 1 1 1 GAG-pre-integrase domain rve PF00665.26 CCF51908.1 - 0.043 14.0 0.1 0.095 12.9 0.1 1.6 2 0 0 2 2 2 0 Integrase core domain DUF3817 PF12823.7 CCF51908.1 - 0.17 12.7 1.7 0.23 12.3 0.5 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3817) Mpv17_PMP22 PF04117.12 CCF51910.1 - 4e-23 81.4 4.8 8.7e-23 80.3 4.8 1.6 1 0 0 1 1 1 1 Mpv17 / PMP22 family PWI PF01480.17 CCF51911.1 - 9.5e-08 32.2 0.3 9.5e-08 32.2 0.3 2.1 2 0 0 2 2 2 1 PWI domain RRM_1 PF00076.22 CCF51911.1 - 8.7e-07 28.7 0.0 4e-06 26.5 0.0 2.2 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Sec23_trunk PF04811.15 CCF51912.1 - 4.2e-74 249.2 0.0 7.5e-74 248.4 0.0 1.4 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.15 CCF51912.1 - 3.7e-23 81.3 0.8 8.2e-23 80.2 0.8 1.7 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Sec23_BS PF08033.12 CCF51912.1 - 5.9e-16 59.0 0.0 1.6e-15 57.6 0.0 1.8 2 0 0 2 2 2 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.15 CCF51912.1 - 5e-15 55.3 9.1 9.5e-15 54.4 9.1 1.5 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger WW PF00397.26 CCF51912.1 - 7e-08 32.4 0.7 1.6e-07 31.3 0.7 1.7 1 0 0 1 1 1 1 WW domain Gelsolin PF00626.22 CCF51912.1 - 2.6e-07 30.4 0.0 5.4e-07 29.4 0.0 1.6 1 0 0 1 1 1 1 Gelsolin repeat Vps36-NZF-N PF16988.5 CCF51912.1 - 0.011 15.1 4.4 0.027 13.8 4.4 1.6 1 0 0 1 1 1 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain IL13 PF03487.13 CCF51914.1 - 0.098 12.4 0.0 0.15 11.8 0.0 1.3 1 0 0 1 1 1 0 Interleukin-13 Glyco_transf_22 PF03901.17 CCF51914.1 - 0.17 11.1 0.0 0.19 10.9 0.0 1.1 1 0 0 1 1 1 0 Alg9-like mannosyltransferase family RT_RNaseH_2 PF17919.1 CCF51916.1 - 3.1e-11 43.2 0.2 9.6e-11 41.6 0.2 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 CCF51916.1 - 1e-06 28.9 0.0 2e-06 28.0 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 CCF51916.1 - 8.9e-05 22.5 0.4 8.9e-05 22.5 0.4 2.1 2 0 0 2 2 2 1 Integrase zinc binding domain RT_RNaseH PF17917.1 CCF51916.1 - 0.12 12.7 0.1 0.46 10.8 0.0 2.0 2 0 0 2 2 2 0 RNase H-like domain found in reverse transcriptase RVT_2 PF07727.14 CCF51917.1 - 1.1e-45 156.1 0.3 1.4e-45 155.9 0.3 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) CKS PF01111.19 CCF51918.1 - 7.3e-35 119.1 0.6 1.3e-34 118.3 0.6 1.4 1 0 0 1 1 1 1 Cyclin-dependent kinase regulatory subunit Tim54 PF11711.8 CCF51918.1 - 0.0082 15.0 13.9 0.011 14.5 13.9 1.2 1 0 0 1 1 1 1 Inner membrane protein import complex subunit Tim54 DUF4407 PF14362.6 CCF51918.1 - 0.081 12.3 3.0 0.13 11.6 3.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Zip PF02535.22 CCF51918.1 - 0.085 12.1 10.7 0.071 12.3 10.7 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 CCF51918.1 - 0.31 9.7 10.6 0.032 13.0 7.0 1.3 2 0 0 2 2 2 0 Presenilin MDM10 PF12519.8 CCF51918.1 - 0.48 9.2 8.3 0.62 8.9 8.3 1.2 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 NPR3 PF03666.13 CCF51918.1 - 9.5 4.9 16.8 13 4.4 16.8 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 AhpC-TSA PF00578.21 CCF51919.1 - 2.3e-26 92.2 0.0 3.6e-26 91.5 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 CCF51919.1 - 2.5e-13 50.0 0.0 4.9e-13 49.0 0.0 1.4 1 0 0 1 1 1 1 Redoxin AhpC-TSA_2 PF13911.6 CCF51919.1 - 0.0095 16.1 0.0 0.017 15.3 0.0 1.4 1 0 0 1 1 1 1 AhpC/TSA antioxidant enzyme DPBB_1 PF03330.18 CCF51920.1 - 9.4e-09 35.4 0.1 1.6e-08 34.7 0.1 1.4 1 0 0 1 1 1 1 Lytic transglycolase PBP1_TM PF14812.6 CCF51922.1 - 0.0006 20.1 5.9 0.00087 19.6 5.9 1.2 1 0 0 1 1 1 1 Transmembrane domain of transglycosylase PBP1 at N-terminal FAM176 PF14851.6 CCF51922.1 - 0.11 12.1 0.7 0.14 11.8 0.7 1.2 1 0 0 1 1 1 0 FAM176 family DUF2796 PF10986.8 CCF51922.1 - 0.12 12.4 4.8 0.15 12.1 4.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2796) LAT PF15234.6 CCF51922.1 - 0.23 11.2 1.8 0.3 10.8 1.8 1.1 1 0 0 1 1 1 0 Linker for activation of T-cells NOA36 PF06524.12 CCF51922.1 - 1.5 8.1 7.0 1.9 7.7 7.0 1.1 1 0 0 1 1 1 0 NOA36 protein Sel1 PF08238.12 CCF51923.1 - 3.3e-39 132.4 30.2 5.1e-06 27.0 0.8 7.7 7 0 0 7 7 7 7 Sel1 repeat TPR_6 PF13174.6 CCF51923.1 - 0.64 10.8 4.9 5.7 7.8 0.1 4.1 3 0 0 3 3 3 0 Tetratricopeptide repeat LSM PF01423.22 CCF51924.1 - 2.1e-12 46.5 0.1 2.6e-12 46.2 0.1 1.1 1 0 0 1 1 1 1 LSM domain DUF2226 PF09987.9 CCF51924.1 - 0.057 12.8 0.0 0.068 12.5 0.0 1.0 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2226) DHO_dh PF01180.21 CCF51925.1 - 2.2e-99 332.4 0.0 3.1e-99 331.9 0.0 1.2 1 0 0 1 1 1 1 Dihydroorotate dehydrogenase FMN_dh PF01070.18 CCF51925.1 - 0.0003 19.9 1.0 0.048 12.7 1.4 2.8 2 1 0 2 2 2 2 FMN-dependent dehydrogenase FAT PF02259.23 CCF51926.1 - 9.4e-125 416.4 5.1 1.1e-124 416.2 3.4 2.0 2 0 0 2 2 2 1 FAT domain PI3_PI4_kinase PF00454.27 CCF51926.1 - 6.8e-69 232.4 0.0 1.3e-68 231.5 0.0 1.5 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase DUF3385 PF11865.8 CCF51926.1 - 4.6e-63 211.9 1.2 3.9e-60 202.4 0.0 4.6 3 1 1 4 4 4 1 Domain of unknown function (DUF3385) FRB_dom PF08771.11 CCF51926.1 - 5.6e-43 145.4 0.3 5.6e-43 145.4 0.3 3.7 3 0 0 3 3 3 1 FKBP12-rapamycin binding domain HEAT_2 PF13646.6 CCF51926.1 - 1.2e-15 57.6 10.3 0.0099 16.3 0.0 10.9 9 2 2 12 12 11 3 HEAT repeats FATC PF02260.20 CCF51926.1 - 2.9e-11 43.0 0.1 7.3e-11 41.7 0.1 1.7 1 0 0 1 1 1 1 FATC domain UME PF08064.13 CCF51926.1 - 1.6e-07 31.2 5.7 0.035 14.0 0.0 5.7 6 0 0 6 6 6 2 UME (NUC010) domain HEAT PF02985.22 CCF51926.1 - 1.2e-06 28.3 18.1 2.2 8.7 0.1 10.8 12 0 0 12 12 11 2 HEAT repeat TPR_19 PF14559.6 CCF51926.1 - 0.00024 21.6 1.0 6.1 7.4 0.0 4.5 4 0 0 4 4 3 2 Tetratricopeptide repeat Cnd1 PF12717.7 CCF51926.1 - 0.00026 21.1 2.5 3.9 7.5 0.1 4.9 3 1 0 4 4 4 1 non-SMC mitotic condensation complex subunit 1 VHS PF00790.19 CCF51926.1 - 0.02 14.7 0.0 3.1 7.6 0.0 3.6 3 0 0 3 3 3 0 VHS domain HEAT_EZ PF13513.6 CCF51926.1 - 0.021 15.3 24.6 3.6 8.2 0.5 10.4 11 1 1 12 12 11 0 HEAT-like repeat TPR_1 PF00515.28 CCF51926.1 - 0.028 14.2 0.2 22 5.1 0.2 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat CLASP_N PF12348.8 CCF51926.1 - 0.044 13.4 2.1 61 3.1 0.0 6.2 5 2 3 8 8 8 0 CLASP N terminal Cas_Csy4 PF09618.10 CCF51926.1 - 0.054 13.6 0.0 0.15 12.2 0.0 1.7 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Csy4) Adaptin_N PF01602.20 CCF51926.1 - 1.5 7.3 6.9 3.1 6.2 0.8 3.5 2 1 0 2 2 2 0 Adaptin N terminal region TPR_9 PF13371.6 CCF51926.1 - 2.2 8.5 5.4 1.5 9.0 0.1 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat Septin PF00735.18 CCF51927.1 - 9.4e-113 376.1 1.3 1.2e-112 375.8 1.3 1.0 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 CCF51927.1 - 2.7e-09 37.1 0.1 6.6e-09 35.9 0.1 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CCF51927.1 - 4.8e-07 29.8 0.3 1.2e-05 25.2 0.1 2.3 2 0 0 2 2 2 1 RsgA GTPase AIG1 PF04548.16 CCF51927.1 - 3.1e-05 23.4 0.0 3.1e-05 23.4 0.0 2.4 3 0 0 3 3 3 1 AIG1 family GTP_EFTU PF00009.27 CCF51927.1 - 3.2e-05 23.6 0.5 0.0025 17.4 0.1 2.5 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 CCF51927.1 - 3.3e-05 24.0 0.3 0.092 12.8 0.1 2.7 1 1 1 2 2 2 2 Dynamin family AAA_16 PF13191.6 CCF51927.1 - 0.00054 20.4 0.0 0.0015 18.9 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain FtsK_SpoIIIE PF01580.18 CCF51927.1 - 0.001 18.5 0.2 0.0023 17.3 0.0 1.6 2 0 0 2 2 2 1 FtsK/SpoIIIE family AAA_7 PF12775.7 CCF51927.1 - 0.0016 18.0 0.1 0.042 13.4 0.0 2.8 3 0 0 3 3 3 1 P-loop containing dynein motor region NB-ARC PF00931.22 CCF51927.1 - 0.0019 17.5 0.0 0.0031 16.8 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain ABC_tran PF00005.27 CCF51927.1 - 0.0047 17.4 2.1 0.0051 17.3 0.1 2.1 2 2 0 2 2 2 1 ABC transporter T2SSE PF00437.20 CCF51927.1 - 0.0072 15.4 0.1 0.014 14.4 0.1 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein IIGP PF05049.13 CCF51927.1 - 0.0098 15.0 0.3 0.022 13.8 0.0 1.7 2 0 0 2 2 2 1 Interferon-inducible GTPase (IIGP) AAA_22 PF13401.6 CCF51927.1 - 0.012 15.9 0.0 0.031 14.5 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 CCF51927.1 - 0.016 15.0 0.1 0.054 13.2 0.0 1.8 2 0 0 2 2 2 0 P-loop containing region of AAA domain Roc PF08477.13 CCF51927.1 - 0.027 14.7 0.0 0.067 13.4 0.0 1.7 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 CCF51927.1 - 0.038 13.3 0.3 0.26 10.6 0.3 2.2 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region AAA_14 PF13173.6 CCF51927.1 - 0.06 13.4 1.6 1.3 9.1 0.0 2.9 2 2 0 2 2 2 0 AAA domain AAA_23 PF13476.6 CCF51927.1 - 0.078 13.5 3.0 0.36 11.3 2.9 2.0 1 1 0 1 1 1 0 AAA domain AAA_24 PF13479.6 CCF51927.1 - 0.082 12.6 0.4 0.2 11.4 0.1 1.9 2 1 0 2 2 2 0 AAA domain DUF87 PF01935.17 CCF51927.1 - 0.15 12.1 1.4 0.88 9.6 0.1 2.3 2 1 0 2 2 2 0 Helicase HerA, central domain SCAMP PF04144.13 CCF51928.1 - 2e-51 174.7 5.6 2.4e-51 174.5 5.6 1.1 1 0 0 1 1 1 1 SCAMP family Bromodomain PF00439.25 CCF51929.1 - 1.8e-36 124.1 1.4 3.7e-18 65.4 0.2 2.8 3 0 0 3 3 3 2 Bromodomain DUF737 PF05300.11 CCF51929.1 - 0.0014 19.0 3.7 0.0014 19.0 3.7 2.9 3 0 0 3 3 3 2 Protein of unknown function (DUF737) TFIIA PF03153.13 CCF51929.1 - 6.9 6.6 69.5 0.082 12.9 12.4 2.7 2 1 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Ctr PF04145.15 CCF51930.1 - 2.8e-28 99.4 0.2 3.4e-28 99.1 0.2 1.1 1 0 0 1 1 1 1 Ctr copper transporter family Halogen_Hydrol PF10112.9 CCF51930.1 - 0.45 10.5 1.8 0.42 10.6 0.6 1.5 2 0 0 2 2 2 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein ECH_1 PF00378.20 CCF51931.1 - 7.3e-23 81.2 0.2 9.7e-23 80.8 0.2 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 CCF51931.1 - 2.9e-08 33.6 0.1 4.9e-08 32.8 0.1 1.3 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase DAO PF01266.24 CCF51932.1 - 9.3e-44 150.4 1.8 1.1e-43 150.1 1.8 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 CCF51932.1 - 0.00023 20.5 0.1 0.028 13.7 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CCF51932.1 - 0.0023 18.0 0.2 0.27 11.2 0.0 2.4 2 0 0 2 2 2 2 FAD-NAD(P)-binding Pyr_redox_2 PF07992.14 CCF51932.1 - 0.0054 16.0 0.0 0.061 12.5 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CCF51932.1 - 0.064 13.5 0.3 0.18 12.1 0.3 1.8 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain PhoLip_ATPase_C PF16212.5 CCF51933.1 - 1.5e-64 218.2 26.0 1.5e-64 218.2 26.0 2.3 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 CCF51933.1 - 5.3e-23 80.5 0.1 1.4e-22 79.1 0.1 1.8 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.26 CCF51933.1 - 1.4e-12 48.3 0.9 2.3e-05 24.8 0.3 3.7 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 CCF51933.1 - 2.4e-12 46.8 0.0 1.2e-11 44.5 0.0 2.1 2 0 0 2 2 2 1 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.20 CCF51933.1 - 7e-06 25.7 0.0 7e-06 25.7 0.0 2.4 2 1 0 2 2 2 1 E1-E2 ATPase Hydrolase_3 PF08282.12 CCF51933.1 - 0.00045 20.0 0.2 0.0067 16.2 0.1 2.4 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase RRM_1 PF00076.22 CCF51934.1 - 2.3e-18 65.8 0.0 3.4e-18 65.2 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CCF51934.1 - 0.023 14.8 0.0 0.035 14.2 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif Nup35_RRM_2 PF14605.6 CCF51934.1 - 0.037 14.0 0.0 0.055 13.5 0.0 1.3 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif Limkain-b1 PF11608.8 CCF51934.1 - 0.071 13.2 0.1 1.9 8.6 0.0 2.3 2 0 0 2 2 2 0 Limkain b1 Aldo_ket_red PF00248.21 CCF51935.1 - 3.9e-40 137.9 0.0 4.6e-40 137.6 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family Pkinase PF00069.25 CCF51936.1 - 1.8e-71 240.6 0.0 2.5e-71 240.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF51936.1 - 2.5e-41 141.7 0.0 3.6e-41 141.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase POLO_box PF00659.18 CCF51936.1 - 3.6e-30 104.0 0.0 3e-16 59.4 0.0 2.6 2 0 0 2 2 2 2 POLO box duplicated region Kinase-like PF14531.6 CCF51936.1 - 5e-08 32.6 0.0 7.1e-06 25.5 0.0 2.2 2 0 0 2 2 2 2 Kinase-like Pkinase_fungal PF17667.1 CCF51936.1 - 6e-05 22.0 0.0 0.00013 20.9 0.0 1.5 1 0 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 CCF51936.1 - 0.007 15.4 0.0 0.011 14.7 0.0 1.3 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 CCF51936.1 - 0.065 13.2 0.4 0.18 11.7 0.0 1.9 2 0 0 2 2 2 0 Phosphotransferase enzyme family BTB PF00651.31 CCF51937.1 - 5.8e-13 49.0 0.2 3.6e-10 40.0 0.0 3.4 3 0 0 3 3 3 1 BTB/POZ domain CAP_GLY PF01302.25 CCF51937.1 - 5.2e-06 26.4 0.0 1.3e-05 25.1 0.0 1.6 1 0 0 1 1 1 1 CAP-Gly domain Ribophorin_II PF05817.14 CCF51938.1 - 1.3e-08 33.9 0.1 3.6e-07 29.2 0.0 2.0 2 0 0 2 2 2 2 Oligosaccharyltransferase subunit Ribophorin II Ribosomal_S10 PF00338.22 CCF51941.1 - 1.1e-28 99.3 0.4 1.3e-28 99.1 0.4 1.1 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e Dor1 PF04124.12 CCF51942.1 - 2.5e-20 72.4 6.4 2.3e-18 66.0 3.2 3.3 2 2 0 2 2 2 2 Dor1-like family Baculo_PEP_C PF04513.12 CCF51942.1 - 0.49 10.4 2.1 4.6 7.3 0.3 3.1 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus TPP_enzyme_N PF02776.18 CCF51943.1 - 2.5e-52 177.0 0.0 7.3e-52 175.4 0.0 1.8 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.21 CCF51943.1 - 2e-48 164.1 0.1 7e-47 159.0 0.1 2.8 3 0 0 3 3 3 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.22 CCF51943.1 - 1.5e-41 141.3 0.5 5.8e-41 139.4 0.2 2.1 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain CO_dh PF02552.16 CCF51943.1 - 0.059 13.1 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 CO dehydrogenase beta subunit/acetyl-CoA synthase epsilon subunit CbtB PF09489.10 CCF51943.1 - 0.064 13.4 0.4 0.2 11.8 0.4 1.8 1 0 0 1 1 1 0 Probable cobalt transporter subunit (CbtB) FAM199X PF15814.5 CCF51943.1 - 6.4 5.7 11.8 13 4.8 11.8 1.4 1 0 0 1 1 1 0 Protein family FAM199X GRAB PF10375.9 CCF51944.1 - 6.2e-08 32.2 1.6 6.2e-08 32.2 1.6 2.4 2 0 0 2 2 2 1 GRIP-related Arf-binding domain Atg14 PF10186.9 CCF51944.1 - 0.0048 16.0 7.4 0.0048 16.0 7.4 2.2 1 1 0 2 2 2 1 Vacuolar sorting 38 and autophagy-related subunit 14 APG6_N PF17675.1 CCF51944.1 - 0.0049 17.4 8.2 0.0049 17.4 8.2 3.3 1 1 2 3 3 1 1 Apg6 coiled-coil region ATG16 PF08614.11 CCF51944.1 - 0.0053 17.0 38.3 0.017 15.3 9.3 2.7 1 1 2 3 3 3 1 Autophagy protein 16 (ATG16) Tup_N PF08581.10 CCF51944.1 - 0.011 16.0 11.8 0.25 11.7 0.1 4.1 3 1 1 4 4 4 0 Tup N-terminal IFT20 PF14931.6 CCF51944.1 - 0.015 15.5 3.2 0.015 15.5 3.2 3.6 2 2 1 3 3 3 0 Intraflagellar transport complex B, subunit 20 Filament PF00038.21 CCF51944.1 - 0.017 14.7 21.9 0.23 11.0 4.2 2.8 1 1 2 3 3 3 0 Intermediate filament protein TPR_MLP1_2 PF07926.12 CCF51944.1 - 0.023 14.8 3.2 0.023 14.8 3.2 3.9 2 2 2 4 4 4 0 TPR/MLP1/MLP2-like protein MscS_porin PF12795.7 CCF51944.1 - 0.028 14.0 26.2 0.53 9.8 15.0 2.6 2 0 0 2 2 2 0 Mechanosensitive ion channel porin domain bZIP_1 PF00170.21 CCF51944.1 - 0.04 14.0 9.1 0.04 14.0 0.1 4.1 3 1 1 4 4 4 0 bZIP transcription factor COG6 PF06419.11 CCF51944.1 - 0.048 11.9 7.3 0.061 11.5 0.3 2.2 2 0 0 2 2 2 0 Conserved oligomeric complex COG6 BLOC1_2 PF10046.9 CCF51944.1 - 0.061 13.6 7.4 1.7 9.0 0.7 2.7 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF3168 PF11367.8 CCF51944.1 - 0.092 12.9 0.3 0.29 11.3 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3168) DUF1664 PF07889.12 CCF51944.1 - 0.12 12.4 6.2 0.4 10.7 0.7 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) Baculo_PEP_C PF04513.12 CCF51944.1 - 0.13 12.3 8.6 0.33 11.0 0.9 2.6 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus LPP PF04728.13 CCF51944.1 - 0.18 12.2 3.3 2.4 8.6 0.0 3.1 2 1 0 2 2 2 0 Lipoprotein leucine-zipper DUF3053 PF11254.8 CCF51944.1 - 0.26 10.9 6.0 0.14 11.8 1.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3053) Allexi_40kDa PF05549.11 CCF51944.1 - 0.35 10.3 7.1 0.053 13.0 0.9 2.1 2 0 0 2 2 2 0 Allexivirus 40kDa protein FliD_N PF02465.18 CCF51944.1 - 0.4 11.4 7.1 1.8 9.3 0.9 3.0 2 1 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus CENP-F_leu_zip PF10473.9 CCF51944.1 - 0.6 10.1 30.3 0.15 12.0 8.2 3.6 1 1 2 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Tho2 PF11262.8 CCF51944.1 - 0.66 9.1 7.2 0.65 9.1 1.2 2.2 2 0 0 2 2 2 0 Transcription factor/nuclear export subunit protein 2 SOGA PF11365.8 CCF51944.1 - 2.4 9.4 22.0 1.9 9.7 1.0 4.3 1 1 2 4 4 3 0 Protein SOGA Phage_GP20 PF06810.11 CCF51944.1 - 2.8 7.8 13.3 5.8 6.7 1.9 3.5 2 2 2 4 4 4 0 Phage minor structural protein GP20 YabA PF06156.13 CCF51944.1 - 3.4 8.4 9.4 0.63 10.7 0.2 3.3 2 2 1 3 3 3 0 Initiation control protein YabA IFT57 PF10498.9 CCF51944.1 - 4.4 6.2 17.3 3.8 6.4 2.4 2.6 2 1 0 2 2 2 0 Intra-flagellar transport protein 57 XhlA PF10779.9 CCF51944.1 - 4.7 7.5 8.1 16 5.8 0.6 3.4 4 0 0 4 4 4 0 Haemolysin XhlA Spc42p PF11544.8 CCF51944.1 - 5.3 7.1 7.0 1.1 9.3 0.3 3.0 2 1 1 3 3 3 0 Spindle pole body component Spc42p JIP_LZII PF16471.5 CCF51944.1 - 6 7.1 12.5 0.41 10.8 1.8 3.5 2 1 1 3 3 3 0 JNK-interacting protein leucine zipper II Phage_GPO PF05929.11 CCF51944.1 - 6.2 6.4 10.4 8.7 5.9 0.2 2.3 2 0 0 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase DUF4407 PF14362.6 CCF51944.1 - 6.4 6.0 24.8 10 5.3 12.0 2.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) PI3K_P85_iSH2 PF16454.5 CCF51944.1 - 6.7 6.3 12.2 0.31 10.6 1.7 3.1 2 2 1 3 3 3 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain Prominin PF05478.11 CCF51944.1 - 7 4.5 5.7 2.1 6.2 0.1 2.0 2 0 0 2 2 2 0 Prominin ADIP PF11559.8 CCF51944.1 - 7.8 6.6 19.3 0.52 10.4 1.7 3.2 2 1 0 2 2 2 0 Afadin- and alpha -actinin-Binding Laminin_II PF06009.12 CCF51944.1 - 8.4 6.4 10.7 11 6.0 2.9 2.7 1 1 0 2 2 2 0 Laminin Domain II KH_8 PF17903.1 CCF51945.1 - 7.3e-34 115.7 0.0 1.6e-33 114.6 0.0 1.6 1 0 0 1 1 1 1 Krr1 KH1 domain KH_1 PF00013.29 CCF51945.1 - 0.00018 21.3 0.1 0.00052 19.8 0.1 1.8 1 0 0 1 1 1 1 KH domain CNDH2_M PF16869.5 CCF51945.1 - 1.5 9.5 10.4 4.4 8.0 5.1 2.5 2 0 0 2 2 2 0 PF16858 SMC_N PF02463.19 CCF51947.1 - 8.5e-60 201.9 14.2 4.2e-58 196.4 14.2 3.1 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 CCF51947.1 - 9.8e-28 96.8 0.3 3.6e-27 95.0 0.1 2.1 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 CCF51947.1 - 4e-15 56.4 12.2 3.2e-10 40.3 0.1 3.5 3 1 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 CCF51947.1 - 2.7e-11 43.8 2.1 2.7e-11 43.8 2.1 4.6 2 2 1 4 4 3 1 AAA ATPase domain AAA_23 PF13476.6 CCF51947.1 - 2e-09 38.3 21.1 2e-09 38.3 21.1 6.6 2 2 2 4 4 2 1 AAA domain AAA_29 PF13555.6 CCF51947.1 - 1.8e-08 34.0 0.0 4.6e-08 32.7 0.0 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain ATG16 PF08614.11 CCF51947.1 - 0.0014 18.9 11.2 0.0014 18.9 11.2 7.2 4 1 1 6 6 5 2 Autophagy protein 16 (ATG16) SbcCD_C PF13558.6 CCF51947.1 - 0.002 18.3 0.0 0.01 16.0 0.0 2.3 2 0 0 2 2 2 1 Putative exonuclease SbcCD, C subunit DUF2968 PF11180.8 CCF51947.1 - 0.0028 17.3 3.5 0.0028 17.3 3.5 7.1 4 3 3 7 7 5 1 Protein of unknown function (DUF2968) TetR_C_5 PF08360.11 CCF51947.1 - 0.02 15.1 0.3 0.17 12.0 0.1 2.6 2 0 0 2 2 2 0 QacR-like protein, C-terminal region ABC_tran PF00005.27 CCF51947.1 - 0.074 13.6 0.0 0.074 13.6 0.0 6.5 4 3 0 5 5 4 0 ABC transporter NPV_P10 PF05531.12 CCF51947.1 - 4.6 7.8 38.1 0.083 13.4 1.9 7.5 6 3 1 7 7 6 0 Nucleopolyhedrovirus P10 protein ING PF12998.7 CCF51948.1 - 5.5e-15 55.8 0.1 4e-13 49.8 0.1 2.4 1 1 0 1 1 1 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.29 CCF51948.1 - 0.00012 21.9 9.0 0.00021 21.1 9.0 1.4 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 CCF51948.1 - 0.0066 16.0 1.8 0.012 15.2 1.8 1.4 1 0 0 1 1 1 1 PHD-finger Glyco_transf_20 PF00982.21 CCF51949.1 - 6.8e-154 513.0 0.0 1.1e-153 512.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.16 CCF51949.1 - 1.2e-64 217.7 0.0 3.5e-64 216.1 0.0 1.8 2 0 0 2 2 2 1 Trehalose-phosphatase Imm2 PF14426.6 CCF51949.1 - 0.14 12.2 0.0 0.49 10.5 0.0 1.9 1 0 0 1 1 1 0 Immunity protein Imm2 GMC_oxred_N PF00732.19 CCF51950.1 - 2.6e-50 171.5 0.0 4e-50 170.9 0.0 1.3 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 CCF51950.1 - 9e-38 130.0 0.1 1.4e-37 129.4 0.1 1.3 1 0 0 1 1 1 1 GMC oxidoreductase NAD_binding_8 PF13450.6 CCF51950.1 - 0.0002 21.5 0.1 0.00054 20.1 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CCF51950.1 - 0.0022 17.3 0.4 0.015 14.5 0.1 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CCF51950.1 - 0.0023 17.6 0.3 0.0073 15.9 0.1 1.9 2 0 0 2 2 2 1 FAD dependent oxidoreductase Thi4 PF01946.17 CCF51950.1 - 0.0027 17.0 0.1 0.0051 16.1 0.1 1.3 1 0 0 1 1 1 1 Thi4 family FAD_binding_2 PF00890.24 CCF51950.1 - 0.0057 15.8 0.4 0.018 14.1 0.2 1.8 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_3 PF13738.6 CCF51950.1 - 0.0062 15.8 0.0 3.6 6.7 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 CCF51950.1 - 0.019 14.0 0.1 0.035 13.2 0.1 1.4 1 0 0 1 1 1 0 Lycopene cyclase protein Pyr_redox PF00070.27 CCF51950.1 - 0.067 13.8 0.1 0.16 12.5 0.1 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 CCF51950.1 - 0.16 11.2 0.1 0.27 10.5 0.1 1.3 1 0 0 1 1 1 0 FAD binding domain COG5 PF10392.9 CCF51951.1 - 1.2e-18 67.5 6.3 1.2e-18 67.5 1.9 3.1 2 1 0 2 2 2 1 Golgi transport complex subunit 5 GP88 PF17338.2 CCF51951.1 - 0.2 11.1 0.0 0.39 10.1 0.0 1.4 1 0 0 1 1 1 0 Gene product 88 dCMP_cyt_deam_1 PF00383.23 CCF51952.1 - 1.6e-25 88.9 1.3 2.4e-25 88.3 1.3 1.3 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 CCF51952.1 - 4.2e-13 49.2 0.2 6.8e-13 48.5 0.2 1.2 1 0 0 1 1 1 1 MafB19-like deaminase SNAD4 PF18750.1 CCF51952.1 - 0.0012 18.9 0.0 0.0027 17.8 0.0 1.6 1 0 0 1 1 1 1 Secreted Novel AID/APOBEC-like Deaminase 4 AAA_18 PF13238.6 CCF51952.1 - 0.0095 16.5 0.0 0.017 15.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain Cytidylate_kin PF02224.18 CCF51952.1 - 0.012 15.3 0.0 0.019 14.7 0.0 1.3 1 0 0 1 1 1 0 Cytidylate kinase AAA_22 PF13401.6 CCF51952.1 - 0.019 15.3 0.0 0.036 14.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 CCF51952.1 - 0.026 14.9 0.0 0.044 14.2 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 CCF51952.1 - 0.026 14.7 0.0 0.052 13.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain APOBEC_N PF08210.11 CCF51952.1 - 0.044 13.7 0.3 0.082 12.8 0.3 1.5 1 0 0 1 1 1 0 APOBEC-like N-terminal domain NAD1 PF18778.1 CCF51952.1 - 0.061 13.4 0.3 0.11 12.6 0.3 1.4 1 0 0 1 1 1 0 Novel AID APOBEC clade 1 APOBEC3 PF18771.1 CCF51952.1 - 0.14 12.3 0.1 0.41 10.8 0.1 1.8 2 0 0 2 2 2 0 APOBEC3 APOBEC2 PF18772.1 CCF51952.1 - 0.18 11.8 0.2 0.36 10.9 0.2 1.4 1 0 0 1 1 1 0 APOBEC2 rve PF00665.26 CCF51953.1 - 0.025 14.8 0.0 0.043 14.0 0.0 1.4 1 0 0 1 1 1 0 Integrase core domain DXP_redisom_C PF08436.12 CCF51953.1 - 0.06 13.5 0.5 0.1 12.7 0.4 1.3 1 1 0 1 1 1 0 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal domain PRTase_1 PF11202.8 CCF51954.1 - 0.13 11.5 0.1 0.24 10.6 0.1 1.3 1 0 0 1 1 1 0 Phosphoribosyl transferase (PRTase) TAF4 PF05236.14 CCF51954.1 - 3.4 7.4 14.4 0.033 13.9 4.2 2.7 2 0 0 2 2 2 0 Transcription initiation factor TFIID component TAF4 family TFIIIC_sub6 PF10419.9 CCF51955.1 - 3.6e-19 68.4 0.0 7.4e-19 67.4 0.0 1.5 1 0 0 1 1 1 1 TFIIIC subunit triple barrel domain FRG PF08867.11 CCF51955.1 - 1.1 10.2 4.7 5.3 8.1 1.0 2.5 2 0 0 2 2 2 0 FRG domain Rpn3_C PF08375.11 CCF51956.1 - 5.5e-27 94.0 1.2 5.5e-27 94.0 1.2 2.4 2 0 0 2 2 2 1 Proteasome regulatory subunit C-terminal PCI PF01399.27 CCF51956.1 - 2.3e-19 69.9 1.3 4.3e-19 69.0 0.5 1.9 2 0 0 2 2 2 1 PCI domain SAC3_GANP PF03399.16 CCF51956.1 - 0.018 14.5 0.3 0.47 9.8 0.1 2.4 2 0 0 2 2 2 0 SAC3/GANP family GAS PF13851.6 CCF51956.1 - 0.067 12.5 1.6 0.15 11.3 1.6 1.6 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding NT-C2 PF10358.9 CCF51957.1 - 1.2e-11 44.5 0.2 0.00069 19.4 0.0 4.3 3 1 0 3 3 3 2 N-terminal C2 in EEIG1 and EHBP1 proteins NicO PF03824.16 CCF51957.1 - 1.3 8.3 5.2 2 7.7 5.2 1.3 1 0 0 1 1 1 0 High-affinity nickel-transport protein PH_9 PF15410.6 CCF51958.1 - 5.1e-08 33.3 0.4 1.7e-07 31.6 0.0 2.1 2 1 0 2 2 2 1 Pleckstrin homology domain PH PF00169.29 CCF51958.1 - 3.1e-07 30.9 0.0 0.036 14.6 0.0 2.5 2 0 0 2 2 2 2 PH domain PH_11 PF15413.6 CCF51958.1 - 0.0076 16.7 0.0 0.062 13.7 0.0 2.5 1 1 0 1 1 1 1 Pleckstrin homology domain Bestrophin PF01062.21 CCF51959.1 - 6e-18 65.3 0.1 2.8e-17 63.1 0.1 1.9 1 1 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel Amelogenin PF02948.15 CCF51959.1 - 0.085 13.5 0.7 0.13 12.9 0.7 1.2 1 0 0 1 1 1 0 Amelogenin NUDIX PF00293.28 CCF51960.1 - 3e-07 30.5 3.5 3e-07 30.5 0.3 2.1 1 1 1 2 2 2 1 NUDIX domain Peptidase_M16_M PF16187.5 CCF51961.1 - 6.5e-98 327.5 1.2 1.1e-97 326.7 1.2 1.4 1 0 0 1 1 1 1 Middle or third domain of peptidase_M16 Peptidase_M16 PF00675.20 CCF51961.1 - 7.4e-43 146.1 1.6 4.1e-41 140.4 0.0 3.7 4 0 0 4 4 4 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 CCF51961.1 - 1.6e-33 116.3 0.1 1.6e-21 77.1 0.0 2.8 2 0 0 2 2 2 2 Peptidase M16 inactive domain HsbA PF12296.8 CCF51961.1 - 0.071 13.5 0.5 0.21 12.0 0.3 1.8 2 0 0 2 2 2 0 Hydrophobic surface binding protein A Aa_trans PF01490.18 CCF51962.1 - 4.8e-32 111.2 36.9 5.5e-32 111.0 36.9 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein DUF2061 PF09834.9 CCF51962.1 - 0.0016 18.9 1.6 0.027 15.0 0.8 3.3 2 0 0 2 2 2 1 Predicted membrane protein (DUF2061) DUF485 PF04341.12 CCF51962.1 - 0.02 14.8 5.9 0.02 14.8 5.9 4.6 5 0 0 5 5 5 0 Protein of unknown function, DUF485 tRNA-synt_1b PF00579.25 CCF51963.1 - 9.6e-75 251.6 0.0 1.4e-74 251.1 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) FmiP_Thoc5 PF09766.9 CCF51964.1 - 2e-32 112.9 22.6 2e-32 112.9 22.6 1.4 2 0 0 2 2 2 1 Fms-interacting protein/Thoc5 SASP PF00269.20 CCF51964.1 - 1.7 8.7 7.2 23 5.1 0.2 3.2 3 1 0 3 3 3 0 Small, acid-soluble spore proteins, alpha/beta type MscS_TM PF12794.7 CCF51964.1 - 9.3 5.0 7.3 16 4.2 7.3 1.4 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 SPA PF08616.10 CCF51965.1 - 2.1e-33 114.7 0.0 4.3e-33 113.7 0.0 1.6 1 0 0 1 1 1 1 Stabilization of polarity axis Afi1 PF07792.12 CCF51965.1 - 6.1e-22 78.5 0.2 1.8e-19 70.5 0.2 2.5 1 1 0 1 1 1 1 Docking domain of Afi1 for Arf3 in vesicle trafficking Avl9 PF09794.9 CCF51965.1 - 1.1e-09 37.6 0.0 0.00087 18.1 0.0 3.6 2 1 1 3 3 3 3 Transport protein Avl9 DUF2347 PF09804.9 CCF51965.1 - 0.004 16.8 0.0 0.73 9.4 0.0 2.5 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2347) Peptidase_C50 PF03568.17 CCF51966.1 - 3.7e-118 395.1 0.1 1.2e-117 393.4 0.0 2.0 2 0 0 2 2 2 1 Peptidase family C50 TPR_4 PF07721.14 CCF51966.1 - 0.0022 18.5 0.5 40 5.3 0.5 4.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 CCF51966.1 - 0.0073 16.4 0.0 44 4.6 0.1 4.9 5 0 0 5 5 5 2 Tetratricopeptide repeat SNF2_N PF00176.23 CCF51967.1 - 1.8e-56 191.4 0.2 3.2e-55 187.3 0.1 2.3 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 CCF51967.1 - 1.5e-15 57.5 0.0 1e-14 54.8 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CCF51967.1 - 7.8e-10 39.0 0.0 1.6e-09 38.0 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit zf-C3HC4 PF00097.25 CCF51967.1 - 9.8e-08 31.8 6.7 9.8e-08 31.8 6.7 2.7 2 1 1 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 CCF51967.1 - 7.2e-07 29.0 7.5 7.2e-07 29.0 7.5 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) DEAD PF00270.29 CCF51967.1 - 1.2e-06 28.4 0.0 2.7e-06 27.3 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase zf-C3HC4_2 PF13923.6 CCF51967.1 - 2.2e-06 27.4 6.6 2.2e-06 27.4 6.6 2.8 2 1 1 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CCF51967.1 - 7.1e-06 26.3 9.0 7.1e-06 26.3 9.0 2.6 2 1 0 2 2 2 1 Ring finger domain Prok-RING_4 PF14447.6 CCF51967.1 - 9.4e-06 25.4 6.0 9.4e-06 25.4 6.0 2.0 2 0 0 2 2 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 CCF51967.1 - 0.0003 20.7 6.4 0.0003 20.7 6.4 2.4 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 CCF51967.1 - 0.00075 19.5 3.7 0.00075 19.5 3.7 2.7 2 1 1 3 3 2 1 RING-type zinc-finger DEAD_2 PF06733.15 CCF51967.1 - 0.029 14.0 0.0 0.18 11.4 0.0 2.3 1 1 0 1 1 1 0 DEAD_2 ERCC3_RAD25_C PF16203.5 CCF51967.1 - 0.035 13.3 0.0 0.069 12.4 0.0 1.4 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase Zn_Tnp_IS91 PF14319.6 CCF51967.1 - 0.26 11.4 13.6 0.23 11.5 2.6 2.6 2 0 0 2 2 2 0 Transposase zinc-binding domain zf-RING_6 PF14835.6 CCF51967.1 - 0.52 10.2 3.9 1.2 9.1 3.9 1.5 1 0 0 1 1 1 0 zf-RING of BARD1-type protein DUF1387 PF07139.11 CCF51967.1 - 8.5 6.0 16.3 0.032 14.0 3.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1387) Ald_Xan_dh_C2 PF02738.18 CCF51968.1 - 8.3e-193 641.8 0.0 1.2e-192 641.3 0.0 1.1 1 0 0 1 1 1 1 Molybdopterin-binding domain of aldehyde dehydrogenase FAD_binding_5 PF00941.21 CCF51968.1 - 2.3e-38 131.6 0.0 1e-37 129.5 0.0 2.2 2 0 0 2 2 2 1 FAD binding domain in molybdopterin dehydrogenase Ald_Xan_dh_C PF01315.22 CCF51968.1 - 1.1e-33 115.8 0.1 2.2e-33 114.9 0.1 1.5 1 0 0 1 1 1 1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain CO_deh_flav_C PF03450.17 CCF51968.1 - 2.7e-27 95.0 0.0 7.1e-27 93.6 0.0 1.8 1 0 0 1 1 1 1 CO dehydrogenase flavoprotein C-terminal domain Fer2_2 PF01799.20 CCF51968.1 - 2.8e-25 88.1 0.0 6.9e-25 86.9 0.0 1.7 1 0 0 1 1 1 1 [2Fe-2S] binding domain Fer2 PF00111.27 CCF51968.1 - 8e-07 28.9 0.0 2.4e-06 27.4 0.0 1.9 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Velvet PF11754.8 CCF51969.1 - 9.6e-18 65.0 1.4 5.1e-14 52.8 0.1 4.9 3 2 1 4 4 4 2 Velvet factor DUF935 PF06074.12 CCF51969.1 - 0.022 13.5 0.3 0.042 12.6 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF935) DUF3245 PF11595.8 CCF51970.1 - 0.054 14.0 3.5 0.08 13.4 3.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3245) DUF4611 PF15387.6 CCF51970.1 - 0.21 11.8 7.6 3.2 8.0 5.4 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) PBP1_TM PF14812.6 CCF51970.1 - 2.4 8.6 7.9 4.8 7.6 7.9 1.4 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Lgl_C PF08596.10 CCF51971.1 - 7.6e-22 77.5 0.0 4.6e-19 68.4 0.0 2.7 2 1 0 2 2 2 2 Lethal giant larvae(Lgl) like, C-terminal ANAPC4_WD40 PF12894.7 CCF51971.1 - 2.1e-07 31.1 0.0 0.0041 17.4 0.0 3.6 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 CCF51971.1 - 0.0011 19.8 1.8 0.15 13.0 0.1 4.9 5 0 0 5 5 5 1 WD domain, G-beta repeat SPX PF03105.19 CCF51972.1 - 1.5e-89 301.7 18.8 1.1e-88 298.8 18.8 2.2 1 1 0 1 1 1 1 SPX domain zf-C3HC4 PF00097.25 CCF51972.1 - 8.1e-08 32.0 5.7 1.4e-07 31.3 5.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 CCF51972.1 - 2.3e-07 30.6 4.9 3.8e-07 29.9 4.9 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CCF51972.1 - 5.5e-06 26.6 7.7 8.9e-06 25.9 7.7 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_4 PF15227.6 CCF51972.1 - 9.6e-06 25.7 6.1 1.7e-05 24.9 6.1 1.4 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 CCF51972.1 - 9.1e-05 22.2 6.9 0.00017 21.4 6.9 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 CCF51972.1 - 0.00011 22.0 7.7 0.00018 21.3 7.7 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CCF51972.1 - 0.0002 21.2 5.7 0.00037 20.4 5.7 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 CCF51972.1 - 0.00093 19.2 7.3 0.0018 18.2 7.3 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_4 PF14570.6 CCF51972.1 - 0.0095 15.7 2.1 0.019 14.7 2.1 1.4 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-RING_6 PF14835.6 CCF51972.1 - 0.014 15.2 2.6 0.028 14.3 2.6 1.4 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-rbx1 PF12678.7 CCF51972.1 - 0.079 13.3 6.1 0.2 12.0 6.1 1.7 1 1 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_10 PF16685.5 CCF51972.1 - 0.77 9.9 4.8 1.7 8.8 4.8 1.5 1 0 0 1 1 1 0 zinc RING finger of MSL2 DEAD PF00270.29 CCF51973.1 - 1.9e-42 145.0 0.1 1.9e-22 79.8 0.3 2.4 1 1 1 2 2 2 2 DEAD/DEAH box helicase DUF4217 PF13959.6 CCF51973.1 - 7.9e-20 70.9 0.2 1.7e-19 69.8 0.2 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) Helicase_C PF00271.31 CCF51973.1 - 9e-19 67.9 0.0 9.9e-18 64.5 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CCF51973.1 - 5.2e-05 23.3 4.4 5.6e-05 23.2 0.0 2.6 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit SbcCD_C PF13558.6 CCF51973.1 - 0.0035 17.6 0.2 0.82 10.0 0.0 3.0 2 0 0 2 2 2 1 Putative exonuclease SbcCD, C subunit CMS1 PF14617.6 CCF51973.1 - 0.77 9.0 0.0 0.77 9.0 0.0 3.7 3 1 0 3 3 3 0 U3-containing 90S pre-ribosomal complex subunit AAA_22 PF13401.6 CCF51973.1 - 0.77 10.0 5.5 0.36 11.1 1.3 2.6 2 1 0 2 2 2 0 AAA domain DUF778 PF05608.12 CCF51973.1 - 5.7 7.3 7.4 15 5.9 1.5 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF778) HATPase_c PF02518.26 CCF51974.1 - 2.6e-29 102.0 0.3 8.6e-29 100.3 0.0 2.1 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 CCF51974.1 - 4.8e-25 87.9 0.1 1.3e-24 86.5 0.1 1.8 1 0 0 1 1 1 1 Response regulator receiver domain PAS_4 PF08448.10 CCF51974.1 - 1.2e-22 80.2 1.4 7.2e-06 26.2 0.0 4.7 4 0 0 4 4 4 3 PAS fold HisKA PF00512.25 CCF51974.1 - 5.7e-19 67.9 0.1 3e-18 65.6 0.0 2.3 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain PAS_3 PF08447.12 CCF51974.1 - 2.5e-13 50.1 2.6 4.9e-13 49.2 1.4 2.1 2 0 0 2 2 2 1 PAS fold PAS PF00989.25 CCF51974.1 - 6.4e-12 45.5 0.3 0.00068 19.6 0.0 5.2 6 0 0 6 6 6 2 PAS fold PAS_9 PF13426.7 CCF51974.1 - 9.6e-09 35.4 0.0 5.7e-05 23.3 0.0 4.4 4 0 0 4 4 4 1 PAS domain PAS_8 PF13188.7 CCF51974.1 - 5.6e-05 23.1 0.0 0.24 11.5 0.0 3.6 3 0 0 3 3 3 2 PAS domain PAS_7 PF12860.7 CCF51974.1 - 0.0048 17.0 0.4 1.5 9.0 0.0 3.4 3 0 0 3 3 3 1 PAS fold AAA_31 PF13614.6 CCF51974.1 - 0.035 14.0 0.0 0.12 12.3 0.0 1.9 1 0 0 1 1 1 0 AAA domain sCache_3_3 PF17202.4 CCF51974.1 - 0.17 12.4 0.0 0.45 11.0 0.0 1.6 1 0 0 1 1 1 0 Single cache domain 3 Malate_synthase PF01274.22 CCF51975.1 - 2.6e-208 692.5 0.0 3e-208 692.4 0.0 1.0 1 0 0 1 1 1 1 Malate synthase HpcH_HpaI PF03328.14 CCF51975.1 - 0.015 14.4 0.0 0.046 12.8 0.0 1.8 1 1 0 1 1 1 0 HpcH/HpaI aldolase/citrate lyase family ALMS_repeat PF18727.1 CCF51975.1 - 0.035 14.0 0.1 3.3 7.7 0.0 3.4 3 0 0 3 3 3 0 Alstrom syndrome repeat Thioredoxin PF00085.20 CCF51976.1 - 6.2e-28 96.8 0.1 7.3e-28 96.6 0.1 1.0 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 CCF51976.1 - 2e-06 28.2 0.3 2.2e-05 24.8 0.3 2.0 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_9 PF14595.6 CCF51976.1 - 5e-05 23.1 0.0 5.8e-05 22.9 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin AhpC-TSA PF00578.21 CCF51976.1 - 0.00012 22.0 0.0 0.00015 21.7 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family Thioredoxin_8 PF13905.6 CCF51976.1 - 0.00015 22.0 0.0 0.18 12.2 0.0 2.2 1 1 1 2 2 2 2 Thioredoxin-like OST3_OST6 PF04756.13 CCF51976.1 - 0.00025 20.5 0.0 0.00025 20.5 0.0 1.1 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Redoxin PF08534.10 CCF51976.1 - 0.0021 17.8 0.3 0.018 14.8 0.4 1.9 1 1 0 1 1 1 1 Redoxin Thioredoxin_7 PF13899.6 CCF51976.1 - 0.0039 17.3 0.0 0.006 16.7 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_5 PF13743.6 CCF51976.1 - 0.0057 16.3 0.0 0.0066 16.2 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin HyaE PF07449.11 CCF51976.1 - 0.043 13.8 0.0 0.058 13.4 0.0 1.2 1 0 0 1 1 1 0 Hydrogenase-1 expression protein HyaE zf-AN1 PF01428.16 CCF51977.1 - 1.5e-17 63.5 21.8 3.3e-11 43.1 4.3 3.1 3 0 0 3 3 3 2 AN1-like Zinc finger Transp_Tc5_C PF04236.15 CCF51977.1 - 0.00026 21.3 15.2 0.004 17.5 4.2 3.2 3 0 0 3 3 3 2 Tc5 transposase C-terminal domain IBR PF01485.21 CCF51977.1 - 0.089 13.0 11.8 0.1 12.8 2.8 2.6 2 1 0 2 2 2 0 IBR domain, a half RING-finger domain BDV_P10 PF06515.11 CCF51977.1 - 0.12 12.4 0.9 0.19 11.8 0.4 1.6 1 1 1 2 2 2 0 Borna disease virus P10 protein Gar1 PF04410.14 CCF51979.1 - 3e-31 108.3 8.8 8.3e-31 106.8 0.0 3.5 4 0 0 4 4 4 2 Gar1/Naf1 RNA binding region Unstab_antitox PF09720.10 CCF51979.1 - 0.013 15.6 2.5 0.013 15.6 2.5 2.6 2 0 0 2 2 2 0 Putative addiction module component API5 PF05918.11 CCF51980.1 - 5.8e-05 22.1 0.1 9.5e-05 21.4 0.1 1.3 1 0 0 1 1 1 1 Apoptosis inhibitory protein 5 (API5) Adaptin_N PF01602.20 CCF51981.1 - 2.1e-96 323.6 0.8 1.2e-82 278.2 1.4 2.1 2 0 0 2 2 2 2 Adaptin N terminal region Cnd1 PF12717.7 CCF51981.1 - 7e-16 58.7 3.0 2.7e-15 56.8 0.4 3.0 4 0 0 4 4 4 1 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 CCF51981.1 - 9.1e-07 28.6 12.0 1.3 9.4 0.0 7.3 7 0 0 7 7 7 3 HEAT repeat HEAT_2 PF13646.6 CCF51981.1 - 9.8e-05 22.7 1.1 9.8e-05 22.7 1.1 5.7 6 1 1 8 8 8 2 HEAT repeats PPP4R2 PF09184.11 CCF51981.1 - 0.07 12.7 25.1 0.12 11.9 25.1 1.4 1 0 0 1 1 1 0 PPP4R2 Kelch_4 PF13418.6 CCF51982.1 - 1e-36 124.7 13.4 2.4e-05 24.2 0.2 6.5 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_5 PF13854.6 CCF51982.1 - 1.7e-32 110.8 4.9 2.2e-06 27.5 0.0 6.4 6 0 0 6 6 6 6 Kelch motif Kelch_1 PF01344.25 CCF51982.1 - 2.9e-32 110.0 2.6 4e-06 26.3 0.0 6.3 6 0 0 6 6 6 5 Kelch motif Kelch_3 PF13415.6 CCF51982.1 - 1.6e-30 104.8 10.7 4e-08 33.4 0.1 7.6 7 0 0 7 7 7 5 Galactose oxidase, central domain Kelch_2 PF07646.15 CCF51982.1 - 5e-28 96.0 12.4 9.4e-07 28.6 0.1 6.7 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.6 CCF51982.1 - 1.8e-25 88.3 10.1 7.9e-06 26.0 0.1 6.0 3 1 3 6 6 6 5 Kelch motif PQQ_3 PF13570.6 CCF51982.1 - 0.031 14.8 2.3 7.5 7.2 0.0 4.0 3 1 1 4 4 4 0 PQQ-like domain Neur_chan_memb PF02932.16 CCF51983.1 - 0.003 17.7 3.0 1.5 8.8 9.3 2.0 2 0 0 2 2 2 1 Neurotransmitter-gated ion-channel transmembrane region SID-1_RNA_chan PF13965.6 CCF51983.1 - 0.093 11.1 0.1 0.091 11.2 0.1 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DDHD PF02862.17 CCF51983.1 - 0.31 11.2 9.3 0.66 10.1 9.3 1.6 1 0 0 1 1 1 0 DDHD domain DUF4407 PF14362.6 CCF51983.1 - 0.58 9.5 16.1 1 8.6 16.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) RR_TM4-6 PF06459.12 CCF51983.1 - 0.65 9.8 18.3 1.4 8.7 18.3 1.6 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Borrelia_P83 PF05262.11 CCF51983.1 - 0.79 8.1 17.6 1.2 7.6 17.6 1.2 1 0 0 1 1 1 0 Borrelia P83/100 protein Presenilin PF01080.17 CCF51983.1 - 3.9 6.1 23.8 7.2 5.3 23.8 1.4 1 0 0 1 1 1 0 Presenilin CNDH2_C PF16858.5 CCF51983.1 - 5.3 6.8 22.4 14 5.4 22.4 1.7 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term adh_short PF00106.25 CCF51984.1 - 2.7e-34 118.3 0.0 3.5e-34 118.0 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF51984.1 - 1.1e-24 87.4 0.0 2.5e-24 86.1 0.0 1.5 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF51984.1 - 2.5e-07 30.8 0.9 4.1e-06 26.8 0.9 2.1 1 1 0 1 1 1 1 KR domain 3Beta_HSD PF01073.19 CCF51984.1 - 0.0031 16.6 0.0 0.0084 15.1 0.0 1.7 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family SRP40_C PF05022.12 CCF51985.1 - 2.3e-28 98.9 1.6 6.8e-28 97.3 1.6 1.9 1 0 0 1 1 1 1 SRP40, C-terminal domain POP1 PF06978.11 CCF51987.1 - 6e-27 95.0 27.7 3e-16 60.0 11.4 3.0 2 1 1 3 3 3 2 Ribonucleases P/MRP protein subunit POP1 POPLD PF08170.12 CCF51987.1 - 3.7e-21 75.3 0.0 1.2e-20 73.6 0.0 1.9 1 0 0 1 1 1 1 POPLD (NUC188) domain GPP34 PF05719.11 CCF51988.1 - 1.8e-76 256.7 0.0 2.2e-76 256.4 0.0 1.1 1 0 0 1 1 1 1 Golgi phosphoprotein 3 (GPP34) Bystin PF05291.11 CCF51989.1 - 1.6e-132 441.2 0.0 2.1e-132 440.8 0.0 1.1 1 0 0 1 1 1 1 Bystin Ribosomal_L15e PF00827.17 CCF51989.1 - 0.028 14.1 0.0 0.061 13.0 0.0 1.5 1 0 0 1 1 1 0 Ribosomal L15 WD40 PF00400.32 CCF51990.1 - 1.6e-55 183.8 17.5 5.8e-09 36.4 0.1 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat Tup_N PF08581.10 CCF51990.1 - 5.5e-26 90.7 4.8 8.7e-26 90.0 4.8 1.3 1 0 0 1 1 1 1 Tup N-terminal ANAPC4_WD40 PF12894.7 CCF51990.1 - 4e-23 81.5 0.8 1.2e-05 25.5 0.0 6.4 1 1 5 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 CCF51990.1 - 8.4e-11 41.7 0.0 0.0013 18.1 0.0 4.2 5 0 0 5 5 5 2 WD40-like domain Ge1_WD40 PF16529.5 CCF51990.1 - 1.4e-07 30.8 0.5 0.5 9.3 0.0 5.8 2 2 5 7 7 7 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 CCF51990.1 - 3.4e-05 22.7 0.2 0.88 8.1 0.0 3.6 2 1 2 4 4 4 3 Nucleoporin Nup120/160 PD40 PF07676.12 CCF51990.1 - 0.00019 21.3 0.0 17 5.5 0.0 5.4 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 CCF51990.1 - 0.0017 17.0 0.2 0.63 8.5 0.0 2.7 1 1 1 2 2 2 2 Cytochrome D1 heme domain Nbas_N PF15492.6 CCF51990.1 - 0.0018 17.7 0.3 0.7 9.2 0.0 3.6 2 2 2 5 5 5 1 Neuroblastoma-amplified sequence, N terminal DUF5046 PF16465.5 CCF51990.1 - 0.0059 16.1 0.1 1.1 8.7 0.0 2.7 1 1 1 2 2 2 1 Domain of unknown function (DUF5046) Striatin PF08232.12 CCF51990.1 - 0.087 13.4 0.5 0.18 12.4 0.5 1.5 1 0 0 1 1 1 0 Striatin family DUF1391 PF07151.12 CCF51990.1 - 0.097 12.5 0.2 0.2 11.5 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1391) Nucleoporin_N PF08801.11 CCF51990.1 - 0.23 10.1 0.4 4.6 5.9 0.3 2.7 1 1 0 1 1 1 0 Nup133 N terminal like fn3_PAP PF17808.1 CCF51991.1 - 0.036 14.2 0.2 0.15 12.2 0.2 2.0 1 0 0 1 1 1 0 Fn3-like domain from Purple Acid Phosphatase PfkB PF00294.24 CCF51992.1 - 3.2e-08 33.2 0.1 7.6e-06 25.4 0.0 2.2 2 0 0 2 2 2 2 pfkB family carbohydrate kinase BEN PF10523.9 CCF51992.1 - 0.094 13.0 0.1 1.4 9.2 0.0 2.3 2 0 0 2 2 2 0 BEN domain DUF3759 PF12585.8 CCF51994.1 - 1.6e-34 117.8 5.3 1.8e-34 117.6 5.3 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3759) Chromo PF00385.24 CCF51995.1 - 2.5e-14 52.9 4.1 7.6e-14 51.4 2.4 2.7 2 0 0 2 2 2 1 Chromo (CHRromatin Organisation MOdifier) domain Chromo_shadow PF01393.19 CCF51995.1 - 1.2e-09 38.1 0.5 1.6e-07 31.3 0.0 2.9 3 0 0 3 3 3 1 Chromo shadow domain RasGAP PF00616.19 CCF51995.1 - 0.019 14.7 3.1 0.04 13.6 3.1 1.5 1 0 0 1 1 1 0 GTPase-activator protein for Ras-like GTPase PBP1_TM PF14812.6 CCF51995.1 - 0.54 10.7 41.0 2.8 8.4 6.5 3.7 2 2 1 3 3 3 0 Transmembrane domain of transglycosylase PBP1 at N-terminal WIF PF02019.18 CCF51996.1 - 0.059 13.1 0.1 1.9 8.2 0.0 2.6 3 0 0 3 3 3 0 WIF domain gag_pre-integrs PF13976.6 CCF51997.1 - 2.7e-09 36.8 0.6 4.9e-09 35.9 0.6 1.5 1 0 0 1 1 1 1 GAG-pre-integrase domain rve PF00665.26 CCF51997.1 - 0.049 13.8 0.1 0.15 12.2 0.0 1.9 2 0 0 2 2 2 0 Integrase core domain RVT_2 PF07727.14 CCF51998.1 - 0.011 15.4 0.0 0.018 14.7 0.0 1.4 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) DUF4589 PF15252.6 CCF51998.1 - 0.023 14.7 0.2 0.045 13.8 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4589) MAGSP PF03082.14 CCF51998.1 - 0.093 12.3 0.1 0.15 11.7 0.1 1.2 1 0 0 1 1 1 0 Male accessory gland secretory protein RVT_2 PF07727.14 CCF51999.1 - 3.7e-40 138.1 0.1 5.1e-40 137.6 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RabGAP-TBC PF00566.18 CCF52000.1 - 1.2e-20 74.1 0.0 3.1e-11 43.4 0.0 3.5 3 0 0 3 3 3 3 Rab-GTPase-TBC domain Myosin_head PF00063.21 CCF52001.1 - 1.1e-272 906.2 0.0 1.1e-272 906.2 0.0 2.6 3 0 0 3 3 3 1 Myosin head (motor domain) Myosin_N PF02736.19 CCF52001.1 - 1.8e-08 34.1 0.0 3.4e-08 33.2 0.0 1.5 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain Myosin_tail_1 PF01576.19 CCF52001.1 - 6.1e-08 31.0 134.5 6.1e-08 31.0 134.5 3.2 3 0 0 3 3 3 2 Myosin tail AAA_19 PF13245.6 CCF52001.1 - 0.016 15.6 0.0 0.016 15.6 0.0 3.6 3 1 0 3 3 3 0 AAA domain Hpr_kinase_C PF07475.12 CCF52001.1 - 0.036 13.6 0.0 0.11 12.0 0.0 1.8 1 0 0 1 1 1 0 HPr Serine kinase C-terminal domain AAA_22 PF13401.6 CCF52001.1 - 0.056 13.7 0.0 0.056 13.7 0.0 4.7 3 1 1 4 4 4 0 AAA domain VRR_NUC PF08774.11 CCF52002.1 - 2.7e-23 82.1 0.1 7.1e-23 80.8 0.1 1.7 1 0 0 1 1 1 1 VRR-NUC domain RRXRR PF14239.6 CCF52002.1 - 0.1 12.4 1.4 0.23 11.3 1.4 1.5 1 0 0 1 1 1 0 RRXRR protein CBFD_NFYB_HMF PF00808.23 CCF52003.1 - 8.8e-11 41.9 0.1 1.9e-10 40.8 0.1 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone PNRC PF15365.6 CCF52004.1 - 5.9e-06 25.9 7.4 5.9e-06 25.9 7.4 3.5 3 0 0 3 3 3 2 Proline-rich nuclear receptor coactivator motif Rad51 PF08423.11 CCF52005.1 - 1.3e-127 424.4 0.0 1.5e-127 424.1 0.0 1.0 1 0 0 1 1 1 1 Rad51 AAA_25 PF13481.6 CCF52005.1 - 6.9e-11 42.1 0.0 9.9e-11 41.6 0.0 1.2 1 0 0 1 1 1 1 AAA domain RecA PF00154.21 CCF52005.1 - 2e-09 37.3 0.1 2.9e-09 36.8 0.1 1.1 1 0 0 1 1 1 1 recA bacterial DNA recombination protein HHH_5 PF14520.6 CCF52005.1 - 4.8e-07 30.3 0.5 1.5e-06 28.7 0.3 1.9 2 0 0 2 2 2 1 Helix-hairpin-helix domain ATPase PF06745.13 CCF52005.1 - 1.6e-06 27.6 0.1 4.1e-06 26.3 0.1 1.7 1 1 0 1 1 1 1 KaiC DnaB_C PF03796.15 CCF52005.1 - 0.0019 17.6 0.1 0.023 14.0 0.0 2.0 2 0 0 2 2 2 1 DnaB-like helicase C terminal domain PAXNEB PF05625.11 CCF52005.1 - 0.0075 15.4 0.8 0.33 10.1 0.7 2.1 1 1 1 2 2 2 1 PAXNEB protein AAA_24 PF13479.6 CCF52005.1 - 0.011 15.5 0.0 0.017 14.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain ssDNA_TraI_N PF18272.1 CCF52005.1 - 0.13 12.3 0.3 0.29 11.2 0.3 1.5 1 0 0 1 1 1 0 single-stranded DNA binding TraI N-terminal subdomain Pyrid_oxidase_2 PF13883.6 CCF52006.1 - 2.3e-25 89.5 0.1 3.4e-25 89.0 0.1 1.2 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase zf-UBR PF02207.20 CCF52007.1 - 1.2e-10 41.4 10.0 1.2e-10 41.4 10.0 3.5 4 1 0 4 4 4 1 Putative zinc finger in N-recognin (UBR box) PHD PF00628.29 CCF52007.1 - 0.001 18.9 1.5 0.001 18.9 1.5 4.0 4 1 0 4 4 4 1 PHD-finger PHD_4 PF16866.5 CCF52007.1 - 0.021 14.9 2.5 0.028 14.5 0.4 2.3 2 0 0 2 2 2 0 PHD-finger PhoLip_ATPase_C PF16212.5 CCF52008.1 - 4.2e-72 242.9 31.7 4.2e-72 242.9 31.7 2.1 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 CCF52008.1 - 5.7e-21 74.0 5.4 5.7e-21 74.0 5.4 2.7 3 0 0 3 3 3 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.26 CCF52008.1 - 1.8e-12 48.0 0.1 2.1e-05 24.9 0.1 3.5 3 0 0 3 3 3 3 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 CCF52008.1 - 1.9e-10 40.7 0.0 3.8e-09 36.5 0.0 2.8 2 1 1 3 3 3 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 CCF52008.1 - 0.00028 20.7 0.3 0.008 15.9 0.2 2.5 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 CCF52008.1 - 0.0041 16.7 0.0 0.0041 16.7 0.0 2.9 3 1 0 3 3 3 1 E1-E2 ATPase Ribosomal_S21 PF01165.20 CCF52010.1 - 0.054 13.2 0.6 0.14 11.9 0.6 1.7 1 0 0 1 1 1 0 Ribosomal protein S21 bZIP_1 PF00170.21 CCF52011.1 - 0.00011 22.2 17.9 0.00037 20.5 17.9 1.9 1 1 0 1 1 1 1 bZIP transcription factor Fmp27_WPPW PF10359.9 CCF52011.1 - 0.13 11.1 5.0 0.2 10.5 5.0 1.2 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain Caldesmon PF02029.15 CCF52011.1 - 0.15 10.8 9.4 0.23 10.2 9.4 1.3 1 0 0 1 1 1 0 Caldesmon SHE3 PF17078.5 CCF52011.1 - 0.17 11.6 8.2 0.3 10.8 8.2 1.3 1 0 0 1 1 1 0 SWI5-dependent HO expression protein 3 bZIP_Maf PF03131.17 CCF52011.1 - 1.1 9.9 16.3 3.1 8.4 16.3 1.7 1 0 0 1 1 1 0 bZIP Maf transcription factor UPF0242 PF06785.11 CCF52011.1 - 1.4 8.9 7.2 2.5 8.2 7.2 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus bZIP_2 PF07716.15 CCF52011.1 - 1.8 8.7 18.4 4.1 7.6 12.3 2.4 1 1 1 2 2 2 0 Basic region leucine zipper GvpL_GvpF PF06386.11 CCF52011.1 - 2.9 7.7 8.0 5.3 6.9 8.0 1.4 1 0 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF Thiolase_N PF00108.23 CCF52012.1 - 1.1e-76 257.6 0.6 1.5e-76 257.2 0.6 1.2 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 CCF52012.1 - 1.8e-48 163.2 0.6 4.6e-48 161.9 0.6 1.7 1 0 0 1 1 1 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 CCF52012.1 - 2.4e-05 24.0 0.7 5.8e-05 22.8 0.7 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain TIM PF00121.18 CCF52013.1 - 3.3e-95 318.1 0.8 3.7e-95 317.9 0.8 1.0 1 0 0 1 1 1 1 Triosephosphate isomerase CutC PF03932.14 CCF52013.1 - 0.00048 19.7 0.1 0.0011 18.5 0.1 1.5 1 1 0 1 1 1 1 CutC family DUF5403 PF17395.2 CCF52013.1 - 0.17 12.2 1.5 0.39 11.0 0.0 2.2 2 1 1 3 3 3 0 Family of unknown function (DUF5403) Profilin PF00235.19 CCF52014.1 - 7.6e-44 149.0 0.0 8.4e-44 148.9 0.0 1.0 1 0 0 1 1 1 1 Profilin SAPS PF04499.15 CCF52015.1 - 7e-176 585.8 1.9 1e-174 582.0 0.0 2.3 2 0 0 2 2 2 1 SIT4 phosphatase-associated protein MIF4G_like_2 PF09090.11 CCF52015.1 - 0.19 11.2 1.3 0.51 9.8 1.3 1.7 1 0 0 1 1 1 0 MIF4G like DIMCO_N PF16844.5 CCF52015.1 - 1 9.7 4.1 9 6.7 0.1 2.7 2 0 0 2 2 2 0 Dinitrogenase iron-molybdenum cofactor, N-terminal DUF4172 PF13776.6 CCF52015.1 - 2.4 8.6 3.9 21 5.5 0.0 3.5 3 1 1 4 4 4 0 Domain of unknown function (DUF4172) EBV-NA3 PF05009.12 CCF52015.1 - 2.4 7.6 4.9 6.7 6.2 4.9 1.7 1 0 0 1 1 1 0 Epstein-Barr virus nuclear antigen 3 (EBNA-3) MCRS_N PF13325.6 CCF52015.1 - 3 7.8 6.5 0.77 9.7 2.8 1.9 2 0 0 2 2 2 0 N-terminal region of micro-spherule protein MOZ_SAS PF01853.18 CCF52016.1 - 1.8e-73 246.0 0.0 2.6e-73 245.5 0.0 1.2 1 0 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 CCF52016.1 - 5e-20 70.9 2.2 5e-20 70.9 2.2 2.1 2 0 0 2 2 2 1 MYST family zinc finger domain PHD PF00628.29 CCF52016.1 - 3.8e-18 65.1 24.7 4.6e-11 42.4 7.3 3.3 2 1 1 3 3 3 2 PHD-finger PHD_4 PF16866.5 CCF52016.1 - 3.6e-05 23.8 4.7 3.6e-05 23.8 4.7 2.7 1 1 1 2 2 2 1 PHD-finger GCP_C_terminal PF04130.13 CCF52017.1 - 5.5e-22 78.6 4.0 7e-22 78.3 1.6 2.4 2 0 0 2 2 2 1 Gamma tubulin complex component C-terminal DUF1168 PF06658.12 CCF52017.1 - 0.051 13.4 8.6 0.26 11.1 8.6 2.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1168) RNA_pol_3_Rpc31 PF11705.8 CCF52017.1 - 3.1 8.0 18.5 0.13 12.5 11.9 2.0 2 0 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 PDDEXK_6 PF04720.12 CCF52018.1 - 1.6 8.6 8.2 1.3 8.9 6.8 1.7 1 1 0 1 1 1 0 PDDEXK-like family of unknown function Pkinase PF00069.25 CCF52019.1 - 1.1e-67 228.2 0.0 1.3e-67 228.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF52019.1 - 2.2e-34 118.9 0.0 7.2e-34 117.2 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 CCF52019.1 - 0.00041 19.4 0.1 0.00061 18.8 0.1 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 CCF52019.1 - 0.0011 18.4 0.3 0.0023 17.3 0.1 1.6 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 CCF52019.1 - 0.0012 18.2 0.0 0.0027 17.1 0.0 1.5 1 1 0 1 1 1 1 Kinase-like APH PF01636.23 CCF52019.1 - 0.0073 16.3 0.1 0.018 14.9 0.2 1.6 1 1 1 2 2 2 1 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 CCF52019.1 - 0.046 12.8 0.3 0.069 12.2 0.3 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Pkinase_fungal PF17667.1 CCF52019.1 - 0.068 11.9 0.0 0.091 11.5 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase FTA2 PF13095.6 CCF52019.1 - 0.085 12.5 0.0 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 YukC PF10140.9 CCF52019.1 - 0.11 11.3 0.0 0.16 10.8 0.0 1.2 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukC Pribosyltran_N PF13793.6 CCF52020.1 - 6.5e-43 145.4 0.1 3.7e-42 142.9 0.0 2.1 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.6 CCF52020.1 - 3.1e-35 121.9 1.3 7.1e-32 110.9 0.4 2.3 2 0 0 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.27 CCF52020.1 - 2.6e-15 56.3 2.0 5.5e-09 35.7 0.7 3.0 3 0 0 3 3 3 2 Phosphoribosyl transferase domain UPRTase PF14681.6 CCF52020.1 - 0.0084 15.6 0.1 0.016 14.7 0.1 1.5 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase 5-FTHF_cyc-lig PF01812.20 CCF52021.1 - 4.3e-37 127.8 0.0 5.1e-37 127.5 0.0 1.1 1 0 0 1 1 1 1 5-formyltetrahydrofolate cyclo-ligase family Peptidase_M17 PF00883.21 CCF52022.1 - 3.1e-114 381.5 0.4 4.1e-114 381.1 0.4 1.2 1 0 0 1 1 1 1 Cytosol aminopeptidase family, catalytic domain Peptidase_M17_N PF02789.17 CCF52022.1 - 0.00018 21.4 0.0 0.00094 19.0 0.0 2.3 2 1 0 2 2 2 1 Cytosol aminopeptidase family, N-terminal domain PUL PF08324.11 CCF52023.1 - 6.4e-47 160.1 0.0 8.7e-47 159.7 0.0 1.2 1 0 0 1 1 1 1 PUL domain PFU PF09070.11 CCF52023.1 - 2.6e-45 153.3 0.4 4.7e-45 152.5 0.4 1.4 1 0 0 1 1 1 1 PFU (PLAA family ubiquitin binding) WD40 PF00400.32 CCF52023.1 - 1.1e-31 108.3 7.4 5.7e-07 30.1 0.1 7.2 7 0 0 7 7 7 6 WD domain, G-beta repeat WD40_like PF17005.5 CCF52023.1 - 0.051 12.9 0.0 0.092 12.1 0.0 1.4 1 0 0 1 1 1 0 WD40-like domain CNOT1_CAF1_bind PF16415.5 CCF52024.1 - 1.3e-47 162.1 2.7 1.5e-47 161.9 2.5 1.2 1 1 0 1 1 1 1 CCR4-NOT transcription complex subunit 1 CAF1-binding domain Gpr1_Fun34_YaaH PF01184.19 CCF52025.1 - 1.4e-30 106.5 23.3 1.7e-30 106.2 23.3 1.0 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family Cytochrom_B561 PF03188.16 CCF52026.1 - 3e-12 46.9 5.6 3e-12 46.9 5.6 1.8 2 0 0 2 2 2 1 Eukaryotic cytochrome b561 DUF4079 PF13301.6 CCF52026.1 - 2 8.5 14.3 5.3 7.2 4.6 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF4079) RRM_1 PF00076.22 CCF52027.1 - 4.7e-31 106.4 0.0 2.3e-19 69.0 0.1 3.6 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP PF00658.18 CCF52027.1 - 8.8e-11 41.8 2.8 1.3e-06 28.5 0.1 3.2 3 0 0 3 3 3 2 Poly-adenylate binding protein, unique domain Limkain-b1 PF11608.8 CCF52027.1 - 3.3e-06 27.1 0.2 0.016 15.3 0.0 2.6 2 0 0 2 2 2 2 Limkain b1 Nup35_RRM_2 PF14605.6 CCF52027.1 - 0.072 13.1 0.0 1.1 9.3 0.0 2.5 3 0 0 3 3 3 0 Nup53/35/40-type RNA recognition motif Pkinase PF00069.25 CCF52029.1 - 5e-60 203.1 0.0 1.8e-35 122.6 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CCF52029.1 - 1.7e-25 89.8 0.0 6.1e-15 55.2 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase_C PF00433.24 CCF52029.1 - 5.5e-10 39.8 4.1 1.4e-09 38.5 2.2 2.9 2 0 0 2 2 2 1 Protein kinase C terminal domain Pkinase_fungal PF17667.1 CCF52029.1 - 0.00077 18.3 0.0 0.0074 15.1 0.0 2.6 2 1 0 2 2 2 1 Fungal protein kinase FTA2 PF13095.6 CCF52029.1 - 0.0053 16.4 0.0 1.4 8.5 0.0 2.4 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 CCF52029.1 - 0.12 11.8 0.0 0.27 10.6 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family PX PF00787.24 CCF52029.1 - 0.12 12.3 0.0 0.49 10.4 0.0 2.0 2 1 0 2 2 2 0 PX domain Metallophos PF00149.28 CCF52030.1 - 1.7e-13 51.5 0.1 2.8e-13 50.8 0.1 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Saf_2TM PF18303.1 CCF52031.1 - 0.051 13.2 0.1 0.14 11.7 0.1 1.7 1 0 0 1 1 1 0 SAVED-fused 2TM effector domain DUF4381 PF14316.6 CCF52031.1 - 2.6 8.3 11.3 1.1 9.4 0.6 4.1 4 0 0 4 4 4 0 Domain of unknown function (DUF4381) ATP_transf PF09830.9 CCF52032.1 - 6.2e-16 58.3 0.0 1.1e-15 57.5 0.0 1.5 1 0 0 1 1 1 1 ATP adenylyltransferase DUF4647 PF15504.6 CCF52032.1 - 0.083 12.0 0.1 0.13 11.3 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4647) MPC PF03650.13 CCF52033.1 - 1.8e-40 137.5 0.3 2.2e-40 137.2 0.3 1.1 1 0 0 1 1 1 1 Mitochondrial pyruvate carriers Hexapep PF00132.24 CCF52034.1 - 9.9e-10 37.8 9.5 0.0013 18.4 0.8 4.3 2 2 1 3 3 3 3 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 CCF52034.1 - 2.4e-05 24.0 7.8 0.00049 19.8 0.2 3.6 4 0 0 4 4 4 2 Hexapeptide repeat of succinyl-transferase Fucokinase PF07959.12 CCF52034.1 - 0.19 10.7 0.7 1.1 8.2 0.7 2.1 1 1 0 1 1 1 0 L-fucokinase FTHFS PF01268.19 CCF52035.1 - 1e-256 852.5 0.3 1e-256 852.5 0.3 1.4 2 0 0 2 2 2 1 Formate--tetrahydrofolate ligase THF_DHG_CYH_C PF02882.19 CCF52035.1 - 5.1e-65 217.7 0.3 5.1e-65 217.7 0.3 1.8 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH PF00763.23 CCF52035.1 - 1.7e-35 121.8 0.1 3.9e-35 120.6 0.1 1.7 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain Ribosomal_L27A PF00828.19 CCF52036.1 - 9.2e-21 74.9 0.1 1.2e-20 74.5 0.1 1.2 1 0 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A DUF5026 PF16429.5 CCF52036.1 - 0.021 14.9 0.4 0.9 9.7 0.8 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF5026) Ribosomal_L16 PF00252.18 CCF52037.1 - 5.6e-43 146.1 0.0 7.2e-43 145.7 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e IBR PF01485.21 CCF52038.1 - 6.3e-20 71.2 42.9 3.2e-11 43.3 3.8 4.5 3 1 1 4 4 4 2 IBR domain, a half RING-finger domain zf-C3HC4_2 PF13923.6 CCF52038.1 - 0.00012 21.8 34.9 0.00057 19.7 1.5 4.8 3 2 1 4 4 4 2 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CCF52038.1 - 0.00013 21.9 1.5 0.00013 21.9 1.5 3.6 3 0 0 3 3 3 2 RING-type zinc-finger zf-C3HC4 PF00097.25 CCF52038.1 - 0.00016 21.4 3.4 0.00016 21.4 3.4 4.3 3 1 1 4 4 4 2 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CCF52038.1 - 0.0011 19.3 3.4 0.0011 19.3 3.4 4.1 3 1 1 4 4 4 2 Ring finger domain zf-RING_5 PF14634.6 CCF52038.1 - 0.0062 16.5 5.1 0.0062 16.5 5.1 4.2 3 1 1 4 4 4 2 zinc-RING finger domain ApoLp-III PF07464.11 CCF52038.1 - 0.021 15.0 0.2 0.044 13.9 0.2 1.5 1 0 0 1 1 1 0 Apolipophorin-III precursor (apoLp-III) DUF2457 PF10446.9 CCF52038.1 - 0.13 11.3 3.2 0.24 10.5 3.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) zf-C3HC4_4 PF15227.6 CCF52038.1 - 0.4 10.9 27.1 0.28 11.4 0.9 4.7 3 2 1 4 4 4 0 zinc finger of C3HC4-type, RING zf-RING_4 PF14570.6 CCF52038.1 - 1.6 8.5 31.1 0.64 9.9 1.9 3.8 3 0 0 3 3 3 0 RING/Ubox like zinc-binding domain AA_permease PF00324.21 CCF52039.1 - 1.9e-128 429.1 40.8 2.2e-128 428.9 40.8 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 CCF52039.1 - 6.5e-36 124.1 43.9 8.9e-36 123.6 43.9 1.2 1 0 0 1 1 1 1 Amino acid permease RSN1_7TM PF02714.15 CCF52040.1 - 1.4e-72 244.3 21.7 2.8e-72 243.3 21.7 1.5 1 0 0 1 1 1 1 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 CCF52040.1 - 4.5e-29 101.2 0.3 4.5e-29 101.2 0.3 2.8 3 0 0 3 3 3 1 Late exocytosis, associated with Golgi transport PHM7_cyt PF14703.6 CCF52040.1 - 2.2e-23 83.4 0.0 4e-23 82.5 0.0 1.5 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter Tfb5 PF06331.12 CCF52041.1 - 8.2e-26 89.8 0.1 8.8e-26 89.7 0.1 1.0 1 0 0 1 1 1 1 Transcription factor TFIIH complex subunit Tfb5 RC-P840_PscD PF10657.9 CCF52041.1 - 0.15 12.1 0.2 0.22 11.6 0.2 1.3 1 1 0 1 1 1 0 Photosystem P840 reaction centre protein PscD DEAD PF00270.29 CCF52042.1 - 3.8e-43 147.3 0.1 5.6e-43 146.7 0.1 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CCF52042.1 - 1.6e-27 96.0 0.6 5.9e-27 94.2 0.3 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain CMS1 PF14617.6 CCF52042.1 - 0.0031 16.9 0.1 0.0062 15.9 0.1 1.4 1 0 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit ResIII PF04851.15 CCF52042.1 - 0.0032 17.5 0.0 0.0077 16.3 0.0 1.7 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit Pam17 PF08566.10 CCF52043.1 - 4.9e-63 211.9 0.0 6.8e-63 211.4 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial import protein Pam17 RrnaAD PF00398.20 CCF52044.1 - 3.4e-19 68.9 0.0 9.4e-19 67.5 0.0 1.6 1 1 0 1 1 1 1 Ribosomal RNA adenine dimethylase DnaJ PF00226.31 CCF52045.1 - 3.1e-20 72.0 0.5 4e-19 68.5 0.2 2.7 2 0 0 2 2 2 1 DnaJ domain V_ATPase_I PF01496.19 CCF52045.1 - 3.9 5.3 8.2 5.2 4.9 8.2 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Ist1 PF03398.14 CCF52046.1 - 6.3e-55 185.6 2.5 8.5e-55 185.1 2.5 1.2 1 0 0 1 1 1 1 Regulator of Vps4 activity in the MVB pathway DUF2052 PF09747.9 CCF52046.1 - 0.0077 16.4 2.0 0.0077 16.4 2.0 1.5 2 0 0 2 2 2 1 Coiled-coil domain containing protein (DUF2052) YARHG PF13308.6 CCF52046.1 - 0.11 12.5 0.0 0.22 11.5 0.0 1.4 1 0 0 1 1 1 0 YARHG domain DNA_primase_S PF01896.19 CCF52047.1 - 2.3e-51 174.4 0.0 3.5e-51 173.7 0.0 1.3 1 0 0 1 1 1 1 DNA primase small subunit zf-AD PF07776.15 CCF52047.1 - 0.084 13.1 0.3 17 5.7 0.2 2.8 2 0 0 2 2 2 0 Zinc-finger associated domain (zf-AD) Clr2 PF10383.9 CCF52048.1 - 4.8e-33 115.0 0.1 8.3e-31 107.7 0.0 2.4 2 0 0 2 2 2 1 Transcription-silencing protein Clr2 Clr2_transil PF16761.5 CCF52048.1 - 2.9e-20 72.9 0.3 1.6e-19 70.5 0.8 2.0 2 0 0 2 2 2 1 Transcription-silencing protein, cryptic loci regulator Clr2 WW PF00397.26 CCF52048.1 - 4.8e-09 36.2 2.5 1e-08 35.1 2.5 1.6 1 0 0 1 1 1 1 WW domain PWWP PF00855.17 CCF52048.1 - 0.0058 17.0 0.1 0.04 14.3 0.0 2.5 2 1 0 2 2 2 1 PWWP domain WD40 PF00400.32 CCF52049.1 - 3.2e-18 65.7 16.4 4.4e-07 30.5 0.0 6.5 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF52049.1 - 0.00044 20.5 0.0 0.81 10.0 0.0 3.6 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CCF52049.1 - 0.044 12.7 0.0 0.37 9.7 0.0 2.4 2 1 1 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein DUF963 PF06131.11 CCF52049.1 - 0.41 10.1 2.6 0.41 10.1 0.4 2.2 2 0 0 2 2 2 0 Schizosaccharomyces pombe repeat of unknown function (DUF963) PBP PF01161.20 CCF52050.1 - 3.4e-09 37.1 0.1 6.1e-09 36.3 0.1 1.3 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein Ribonuclease_P PF00825.18 CCF52053.1 - 0.039 14.0 1.5 0.068 13.3 1.5 1.4 1 1 0 1 1 1 0 Ribonuclease P Ribosomal_L7Ae PF01248.26 CCF52054.1 - 4e-24 84.2 0.2 9.1e-24 83.0 0.2 1.6 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family RNase_P_pop3 PF08228.11 CCF52054.1 - 0.0034 17.4 0.0 0.0071 16.4 0.0 1.5 2 0 0 2 2 2 1 RNase P subunit Pop3 Npun_R1517 PF18068.1 CCF52054.1 - 0.068 13.5 0.0 0.13 12.6 0.0 1.4 1 0 0 1 1 1 0 Npun R1517 NST1 PF13945.6 CCF52054.1 - 2.7 8.1 10.8 4.9 7.2 10.8 1.4 1 0 0 1 1 1 0 Salt tolerance down-regulator ATG11 PF10377.9 CCF52055.1 - 8.7e-34 116.4 2.4 1.7e-33 115.4 0.1 2.6 2 0 0 2 2 2 1 Autophagy-related protein 11 NleF_casp_inhib PF16809.5 CCF52055.1 - 0.31 10.9 4.2 4.4 7.2 1.7 2.9 2 0 0 2 2 2 0 NleF caspase inhibitor DUF1664 PF07889.12 CCF52055.1 - 0.73 9.9 18.4 0.076 13.1 4.0 4.6 4 1 1 5 5 5 0 Protein of unknown function (DUF1664) KxDL PF10241.9 CCF52055.1 - 2.9 8.2 7.9 6.1 7.2 0.3 4.1 1 1 1 2 2 2 0 Uncharacterized conserved protein FlaC_arch PF05377.11 CCF52055.1 - 9.1 6.8 12.8 24 5.4 0.2 5.7 5 2 2 7 7 7 0 Flagella accessory protein C (FlaC) RT_RNaseH_2 PF17919.1 CCF52056.1 - 2.9e-18 65.7 0.3 3.8e-16 59.0 0.1 3.2 2 1 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 CCF52056.1 - 2.9e-14 53.2 0.1 1.3e-13 51.1 0.0 2.2 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase zf-CCHC PF00098.23 CCF52056.1 - 0.035 14.2 5.9 0.1 12.7 5.9 1.8 1 0 0 1 1 1 0 Zinc knuckle Sar8_2 PF03058.14 CCF52056.1 - 0.078 13.5 0.0 0.25 11.9 0.0 1.9 2 0 0 2 2 2 0 Sar8.2 family PH_3 PF14593.6 CCF52057.1 - 0.1 12.7 0.1 0.15 12.2 0.1 1.2 1 0 0 1 1 1 0 PH domain FHA PF00498.26 CCF52058.1 - 3.2e-13 49.8 0.0 7.1e-13 48.7 0.0 1.6 1 0 0 1 1 1 1 FHA domain zf-RING_11 PF17123.5 CCF52058.1 - 4.6e-11 42.3 12.4 8.8e-11 41.4 12.4 1.5 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_2 PF13639.6 CCF52058.1 - 7.1e-07 29.5 11.9 1.2e-06 28.8 11.9 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 CCF52058.1 - 0.0031 17.3 12.4 0.0058 16.4 12.4 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 CCF52058.1 - 0.0032 17.7 6.9 0.0065 16.7 6.9 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 CCF52058.1 - 0.012 15.4 11.6 0.023 14.6 11.6 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 CCF52058.1 - 0.016 15.3 4.1 0.027 14.5 4.1 1.3 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_5 PF14634.6 CCF52058.1 - 0.074 13.0 10.4 0.13 12.2 10.4 1.4 1 0 0 1 1 1 0 zinc-RING finger domain zf-RING_UBOX PF13445.6 CCF52058.1 - 0.94 9.6 11.4 2.1 8.4 11.4 1.7 1 0 0 1 1 1 0 RING-type zinc-finger PHD PF00628.29 CCF52058.1 - 5.3 7.0 7.2 9.6 6.2 7.2 1.4 1 0 0 1 1 1 0 PHD-finger Zn_ribbon_17 PF17120.5 CCF52058.1 - 8 6.2 9.0 14 5.4 9.0 1.3 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type ISG65-75 PF11727.8 CCF52059.1 - 0.079 12.2 9.2 0.098 11.9 9.2 1.2 1 0 0 1 1 1 0 Invariant surface glycoprotein DUF4407 PF14362.6 CCF52059.1 - 6.8 5.9 11.4 8.5 5.6 11.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) zf-RING_2 PF13639.6 CCF52060.1 - 4.3e-11 43.0 3.1 1.2e-08 35.1 0.9 2.5 2 0 0 2 2 2 2 Ring finger domain zf-rbx1 PF12678.7 CCF52060.1 - 3.9e-10 39.8 1.0 1.1e-08 35.2 0.3 2.7 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_11 PF17123.5 CCF52060.1 - 2.9e-08 33.3 0.7 0.00012 21.7 0.1 2.6 2 0 0 2 2 2 2 RING-like zinc finger zf-C3HC4_2 PF13923.6 CCF52060.1 - 3e-07 30.2 1.5 3e-07 30.2 1.5 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 CCF52060.1 - 2.4e-05 24.3 0.6 0.0001 22.3 0.2 2.3 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4 PF00097.25 CCF52060.1 - 3.2e-05 23.7 3.5 9.2e-05 22.2 0.3 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 CCF52060.1 - 0.00028 20.7 3.2 0.003 17.4 0.5 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) EI24 PF07264.11 CCF52060.1 - 0.00045 20.5 0.1 0.0017 18.7 0.1 2.0 1 1 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) zf-RING_5 PF14634.6 CCF52060.1 - 0.00088 19.2 2.7 0.0017 18.3 0.3 2.2 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 CCF52060.1 - 0.0015 18.5 2.0 0.038 14.0 0.2 2.6 2 0 0 2 2 2 1 RING-type zinc-finger Zn_ribbon_17 PF17120.5 CCF52060.1 - 0.006 16.2 0.5 0.014 15.0 0.5 1.6 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type Prok-RING_4 PF14447.6 CCF52060.1 - 0.029 14.2 0.5 0.029 14.2 0.5 2.7 3 0 0 3 3 3 0 Prokaryotic RING finger family 4 zf-RING_4 PF14570.6 CCF52060.1 - 0.14 11.9 1.6 0.41 10.5 0.3 2.1 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain FANCL_C PF11793.8 CCF52060.1 - 0.78 10.0 8.9 27 5.0 4.9 3.2 2 1 0 2 2 2 0 FANCL C-terminal domain GCFC PF07842.12 CCF52061.1 - 8.1e-59 199.5 0.3 1.1e-58 199.0 0.3 1.2 1 0 0 1 1 1 1 GC-rich sequence DNA-binding factor-like protein TIP_N PF12457.8 CCF52061.1 - 2.6e-13 50.2 8.9 2.6e-13 50.2 8.9 2.7 3 0 0 3 3 3 1 Tuftelin interacting protein N terminal G-patch PF01585.23 CCF52061.1 - 3e-10 39.8 0.4 3e-10 39.8 0.4 2.5 2 0 0 2 2 2 1 G-patch domain G-patch_2 PF12656.7 CCF52061.1 - 0.0042 17.2 0.1 0.0042 17.2 0.1 2.8 4 0 0 4 4 4 1 G-patch domain HSF_DNA-bind PF00447.17 CCF52062.1 - 6.2e-31 106.9 1.8 1.2e-30 106.0 1.8 1.5 1 0 0 1 1 1 1 HSF-type DNA-binding Response_reg PF00072.24 CCF52062.1 - 6.1e-25 87.6 0.0 1.4e-24 86.4 0.0 1.6 1 0 0 1 1 1 1 Response regulator receiver domain Mcp5_PH PF12814.7 CCF52063.1 - 6.2e-45 152.3 0.1 1.4e-44 151.1 0.1 1.7 1 0 0 1 1 1 1 Meiotic cell cortex C-terminal pleckstrin homology PH PF00169.29 CCF52063.1 - 1.9e-05 25.1 0.0 4.3e-05 24.0 0.0 1.6 1 0 0 1 1 1 1 PH domain SAM_2 PF07647.17 CCF52064.1 - 3.7e-10 39.8 0.0 7.3e-10 38.8 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 CCF52064.1 - 2.6e-06 27.7 0.2 7.6e-06 26.3 0.0 1.8 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) IGR PF09597.10 CCF52064.1 - 0.056 13.5 0.2 0.13 12.4 0.2 1.6 1 0 0 1 1 1 0 IGR protein motif SAM_3 PF18016.1 CCF52064.1 - 0.094 12.5 1.1 2.4 8.0 0.0 2.5 2 0 0 2 2 2 0 SAM domain (Sterile alpha motif) DUF4508 PF14969.6 CCF52064.1 - 1.3 9.3 3.5 0.34 11.2 0.2 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4508) ABC_tran PF00005.27 CCF52067.1 - 4.3e-33 114.7 0.1 8.1e-16 58.8 0.0 2.9 2 1 0 2 2 2 2 ABC transporter RLI PF04068.15 CCF52067.1 - 7.2e-14 51.3 5.8 7.2e-14 51.3 5.8 2.0 2 0 0 2 2 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI SMC_N PF02463.19 CCF52067.1 - 2.3e-10 40.3 5.7 0.001 18.5 0.9 3.8 2 2 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 CCF52067.1 - 1.3e-09 38.3 2.2 0.2 11.5 0.8 4.2 3 1 0 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system AAA PF00004.29 CCF52067.1 - 1.3e-05 25.7 0.0 0.032 14.7 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) RsgA_GTPase PF03193.16 CCF52067.1 - 1.9e-05 24.7 0.1 0.25 11.2 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase AAA_22 PF13401.6 CCF52067.1 - 2.2e-05 24.7 0.0 0.0076 16.5 0.0 2.5 2 0 0 2 2 2 1 AAA domain Fer4 PF00037.27 CCF52067.1 - 2.5e-05 23.9 3.0 2.5e-05 23.9 3.0 2.7 3 0 0 3 3 3 1 4Fe-4S binding domain AAA_16 PF13191.6 CCF52067.1 - 6.4e-05 23.4 0.1 0.042 14.2 0.0 2.5 2 1 0 2 2 2 1 AAA ATPase domain Fer4_10 PF13237.6 CCF52067.1 - 7.7e-05 22.7 8.5 0.0037 17.3 0.1 2.4 2 0 0 2 2 2 1 4Fe-4S dicluster domain AAA_29 PF13555.6 CCF52067.1 - 0.00016 21.3 0.5 0.51 10.1 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_15 PF13175.6 CCF52067.1 - 0.00025 20.9 7.7 0.13 12.0 0.3 3.5 3 1 1 4 4 4 2 AAA ATPase domain RNA_helicase PF00910.22 CCF52067.1 - 0.00047 20.5 0.3 0.2 12.1 0.0 3.2 3 0 0 3 3 2 1 RNA helicase AAA_7 PF12775.7 CCF52067.1 - 0.0005 19.6 0.3 0.0087 15.6 0.0 2.5 2 0 0 2 2 2 1 P-loop containing dynein motor region Fer4_6 PF12837.7 CCF52067.1 - 0.00073 19.5 11.8 0.0039 17.2 2.7 2.5 2 0 0 2 2 2 1 4Fe-4S binding domain AAA_24 PF13479.6 CCF52067.1 - 0.001 18.8 0.2 0.41 10.3 0.1 2.4 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 CCF52067.1 - 0.0012 18.8 1.2 0.1 12.5 0.0 2.4 2 0 0 2 2 2 1 NACHT domain NB-ARC PF00931.22 CCF52067.1 - 0.0016 17.6 0.1 0.12 11.5 0.0 2.3 2 0 0 2 2 2 1 NB-ARC domain Fer4_7 PF12838.7 CCF52067.1 - 0.0018 18.8 8.9 0.011 16.4 0.2 2.5 2 0 0 2 2 2 1 4Fe-4S dicluster domain AAA_33 PF13671.6 CCF52067.1 - 0.0024 18.0 0.6 0.55 10.4 0.0 2.6 2 1 0 2 2 2 1 AAA domain Rad17 PF03215.15 CCF52067.1 - 0.0028 17.6 0.0 0.4 10.6 0.0 2.5 2 0 0 2 2 2 1 Rad17 P-loop domain SRP54 PF00448.22 CCF52067.1 - 0.0035 17.0 1.9 0.29 10.7 0.0 2.3 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain Fer4_21 PF14697.6 CCF52067.1 - 0.0042 17.2 11.9 0.011 15.9 11.9 1.7 1 1 0 1 1 1 1 4Fe-4S dicluster domain TsaE PF02367.17 CCF52067.1 - 0.0042 17.1 0.1 0.087 12.8 0.0 2.4 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_28 PF13521.6 CCF52067.1 - 0.0066 16.7 0.6 1.8 8.8 0.0 2.4 2 0 0 2 2 2 1 AAA domain Fer4_9 PF13187.6 CCF52067.1 - 0.014 15.6 10.3 0.04 14.1 10.5 1.8 1 1 0 1 1 1 0 4Fe-4S dicluster domain AAA_18 PF13238.6 CCF52067.1 - 0.027 15.0 0.1 7.3 7.2 0.0 2.6 2 0 0 2 2 2 0 AAA domain VirE PF05272.11 CCF52067.1 - 0.029 14.1 0.0 1.8 8.2 0.0 2.3 2 0 0 2 2 2 0 Virulence-associated protein E SbcCD_C PF13558.6 CCF52067.1 - 0.037 14.3 0.0 14 6.0 0.0 2.8 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit AAA_30 PF13604.6 CCF52067.1 - 0.049 13.4 0.3 3.3 7.4 0.0 2.4 2 0 0 2 2 2 0 AAA domain Fer4_16 PF13484.6 CCF52067.1 - 0.051 14.5 0.3 0.051 14.5 0.3 2.7 2 1 1 3 3 2 0 4Fe-4S double cluster binding domain MMR_HSR1 PF01926.23 CCF52067.1 - 0.094 12.8 0.6 16 5.7 0.0 2.7 2 1 0 2 2 2 0 50S ribosome-binding GTPase Thymidylate_kin PF02223.17 CCF52067.1 - 0.12 12.1 0.7 9.7 5.8 0.0 2.9 3 0 0 3 3 3 0 Thymidylate kinase AAA_14 PF13173.6 CCF52067.1 - 0.14 12.1 1.5 32 4.6 0.0 3.4 2 1 1 3 3 3 0 AAA domain Roc PF08477.13 CCF52067.1 - 0.23 11.7 0.4 2.4 8.4 0.0 2.4 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_5 PF07728.14 CCF52067.1 - 0.24 11.4 2.0 1.6 8.7 0.1 2.9 3 1 0 3 3 2 0 AAA domain (dynein-related subfamily) NTPase_1 PF03266.15 CCF52067.1 - 0.27 11.1 1.2 8.5 6.3 0.1 3.2 3 0 0 3 3 3 0 NTPase Fer4_8 PF13183.6 CCF52067.1 - 0.35 11.3 0.1 0.35 11.3 0.1 2.5 2 0 0 2 2 2 0 4Fe-4S dicluster domain AAA_23 PF13476.6 CCF52067.1 - 0.98 9.9 11.8 0.1 13.1 1.0 2.6 2 1 0 3 3 2 0 AAA domain Fer4_2 PF12797.7 CCF52067.1 - 1.9 8.7 9.7 0.29 11.3 1.1 2.6 2 0 0 2 2 2 0 4Fe-4S binding domain ATG27 PF09451.10 CCF52069.1 - 9.7e-76 255.1 0.0 1.2e-75 254.7 0.0 1.1 1 0 0 1 1 1 1 Autophagy-related protein 27 CIMR PF00878.18 CCF52069.1 - 0.099 12.7 0.0 18 5.4 0.1 2.1 2 0 0 2 2 2 0 Cation-independent mannose-6-phosphate receptor repeat TTL PF03133.15 CCF52070.1 - 2.7e-46 158.0 0.0 4.7e-45 154.0 0.0 2.1 1 1 0 1 1 1 1 Tubulin-tyrosine ligase family INCENP_ARK-bind PF03941.15 CCF52071.1 - 5.8e-12 45.4 0.2 5.8e-12 45.4 0.2 3.3 4 0 0 4 4 4 1 Inner centromere protein, ARK binding region Tic110 PF16940.5 CCF52071.1 - 0.0031 16.1 7.1 0.008 14.7 7.1 1.6 1 0 0 1 1 1 1 Chloroplast envelope transporter Acyltransferase PF01553.21 CCF52073.1 - 1.5e-11 44.0 0.0 7.7e-10 38.5 0.0 2.5 1 1 0 1 1 1 1 Acyltransferase DUF617 PF04759.13 CCF52074.1 - 0.037 14.1 0.0 0.051 13.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF617 Wbp11 PF09429.10 CCF52075.1 - 1.3e-14 54.3 17.6 1.3e-14 54.3 17.6 2.2 2 0 0 2 2 2 1 WW domain binding protein 11 NpwBP PF12622.7 CCF52075.1 - 1.4e-12 48.2 6.7 1.4e-12 48.2 6.7 3.6 2 2 0 2 2 2 1 mRNA biogenesis factor DUF4686 PF15742.5 CCF52075.1 - 0.018 14.2 9.6 0.032 13.4 9.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4686) NuA4 PF09340.10 CCF52075.1 - 0.67 9.9 3.0 2 8.4 0.0 2.4 2 0 0 2 2 2 0 Histone acetyltransferase subunit NuA4 APG6_N PF17675.1 CCF52075.1 - 3.6 8.1 15.3 0.27 11.8 9.1 2.2 3 0 0 3 3 3 0 Apg6 coiled-coil region FUSC PF04632.12 CCF52075.1 - 6.2 5.2 6.6 10 4.5 6.6 1.3 1 0 0 1 1 1 0 Fusaric acid resistance protein family Peptidase_C48 PF02902.19 CCF52076.1 - 5.4e-09 36.2 0.0 7.2e-09 35.8 0.0 1.1 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain VASt PF16016.5 CCF52077.1 - 2.1e-37 128.9 0.1 3.6e-37 128.1 0.1 1.4 1 0 0 1 1 1 1 VAD1 Analog of StAR-related lipid transfer domain GRAM PF02893.20 CCF52077.1 - 1.4e-24 86.2 0.1 3.9e-24 84.7 0.0 1.8 2 0 0 2 2 2 1 GRAM domain DUF2613 PF11021.8 CCF52077.1 - 0.047 13.8 0.2 0.047 13.8 0.2 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2613) DASH_Spc19 PF08287.11 CCF52078.1 - 2.6e-37 128.1 17.2 2.6e-37 128.1 17.2 1.7 2 0 0 2 2 2 1 Spc19 MVP_shoulder PF11978.8 CCF52078.1 - 0.07 13.1 0.2 0.11 12.5 0.2 1.4 1 0 0 1 1 1 0 Shoulder domain BLOC1_2 PF10046.9 CCF52078.1 - 0.28 11.5 12.1 0.59 10.5 0.6 3.2 2 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 BP28CT PF08146.12 CCF52081.1 - 2.3e-39 134.8 0.2 9.2e-38 129.6 1.4 3.0 3 0 0 3 3 3 1 BP28CT (NUC211) domain U3snoRNP10 PF12397.8 CCF52081.1 - 1.4e-16 60.9 4.3 1.4e-16 60.9 4.3 5.3 5 0 0 5 5 5 1 U3 small nucleolar RNA-associated protein 10 HEAT PF02985.22 CCF52081.1 - 0.00093 19.3 0.9 0.1 12.9 0.2 4.3 2 0 0 2 2 2 1 HEAT repeat HEAT_EZ PF13513.6 CCF52081.1 - 0.026 15.0 12.0 0.94 10.1 0.2 6.1 6 0 0 6 6 6 0 HEAT-like repeat Cnd1 PF12717.7 CCF52081.1 - 0.033 14.2 0.6 0.62 10.1 0.0 3.3 3 0 0 3 3 3 0 non-SMC mitotic condensation complex subunit 1 RTP1_C1 PF10363.9 CCF52081.1 - 0.067 13.4 3.6 26 5.0 0.0 4.6 4 0 0 4 4 4 0 Required for nuclear transport of RNA pol II C-terminus 1 CLASP_N PF12348.8 CCF52081.1 - 0.15 11.6 4.5 4 7.0 0.0 4.2 3 0 0 3 3 3 0 CLASP N terminal HEAT_2 PF13646.6 CCF52081.1 - 0.53 10.7 16.3 2.1 8.8 0.7 6.2 4 1 1 5 5 5 0 HEAT repeats FCD PF07729.12 CCF52082.1 - 0.073 13.5 2.0 17 5.9 0.0 3.4 3 0 0 3 3 3 0 FCD domain Herpes_LMP2 PF07415.11 CCF52082.1 - 0.5 9.1 6.3 0.81 8.4 6.3 1.2 1 0 0 1 1 1 0 Gammaherpesvirus latent membrane protein (LMP2) protein DUF2236 PF09995.9 CCF52083.1 - 1.4e-57 195.5 0.9 2.7e-57 194.6 0.9 1.5 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2236) Rad1 PF02144.16 CCF52084.1 - 4.1e-97 324.6 0.0 5e-97 324.3 0.0 1.1 1 0 0 1 1 1 1 Repair protein Rad1/Rec1/Rad17 His_Phos_2 PF00328.22 CCF52085.1 - 5.6e-36 124.7 0.0 6.5e-36 124.5 0.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) Vpu PF00558.19 CCF52086.1 - 0.6 9.9 4.1 0.43 10.4 2.7 1.5 1 1 1 2 2 2 0 Vpu protein RVT_2 PF07727.14 CCF52088.1 - 8.3e-43 146.8 2.2 1.5e-42 145.9 0.9 2.1 2 1 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos PF03372.23 CCF52089.1 - 5.8e-06 26.0 0.2 1.2e-05 24.9 0.2 1.7 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family ChiW_Ig_like PF18683.1 CCF52089.1 - 0.038 14.2 0.0 0.39 11.0 0.0 2.3 2 0 0 2 2 2 0 Chitinase W immunoglobulin-like domain CAP59_mtransfer PF11735.8 CCF52090.1 - 2.8e-68 230.2 0.0 3.6e-68 229.8 0.0 1.1 1 0 0 1 1 1 1 Cryptococcal mannosyltransferase 1 Sugar_tr PF00083.24 CCF52091.1 - 8.5e-115 384.2 14.0 9.8e-115 384.0 14.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF52091.1 - 1.1e-22 80.5 42.0 2.9e-18 65.9 22.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 CCF52091.1 - 0.011 14.2 0.7 0.019 13.4 0.7 1.3 1 0 0 1 1 1 0 Fungal trichothecene efflux pump (TRI12) YqhR PF11085.8 CCF52091.1 - 0.14 12.1 4.3 0.19 11.6 0.5 3.0 2 1 0 2 2 2 0 Conserved membrane protein YqhR GRAM PF02893.20 CCF52091.1 - 0.18 11.7 0.0 0.43 10.5 0.0 1.5 1 0 0 1 1 1 0 GRAM domain OstA PF03968.14 CCF52092.1 - 0.14 12.4 0.0 12 6.2 0.0 2.1 2 0 0 2 2 2 0 OstA-like protein PAN_4 PF14295.6 CCF52093.1 - 8.4e-05 22.4 0.4 0.00017 21.4 0.4 1.5 1 0 0 1 1 1 1 PAN domain PAN_1 PF00024.26 CCF52093.1 - 0.013 15.5 0.0 0.027 14.4 0.0 1.5 1 0 0 1 1 1 0 PAN domain MANEC PF07502.14 CCF52093.1 - 0.017 15.4 0.1 0.043 14.1 0.1 1.6 1 0 0 1 1 1 0 MANEC domain Glyco_hydro_88 PF07470.13 CCF52094.1 - 2.3e-15 56.5 1.5 4e-15 55.7 1.5 1.2 1 0 0 1 1 1 1 Glycosyl Hydrolase Family 88 AMP-binding PF00501.28 CCF52094.1 - 2e-05 23.4 0.0 3.4e-05 22.6 0.0 1.4 1 0 0 1 1 1 1 AMP-binding enzyme Zn_clus PF00172.18 CCF52095.1 - 5.9e-06 26.3 10.0 1.1e-05 25.5 10.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain ACOX PF01756.19 CCF52096.1 - 3e-44 150.7 0.5 1.3e-43 148.6 0.1 2.0 2 0 0 2 2 2 1 Acyl-CoA oxidase Acyl-CoA_ox_N PF14749.6 CCF52096.1 - 1.1e-23 84.2 0.1 2.1e-23 83.2 0.1 1.5 1 0 0 1 1 1 1 Acyl-coenzyme A oxidase N-terminal Acyl-CoA_dh_M PF02770.19 CCF52096.1 - 2.2e-12 47.0 0.0 4e-12 46.2 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_1 PF00441.24 CCF52096.1 - 0.00058 20.1 0.8 0.028 14.6 0.4 2.6 2 1 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain G_glu_transpept PF01019.21 CCF52097.1 - 1.6e-143 479.2 0.2 1.8e-143 479.0 0.2 1.0 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase PNK3P PF08645.11 CCF52098.1 - 1.6e-47 161.2 0.0 3.2e-47 160.2 0.0 1.5 1 0 0 1 1 1 1 Polynucleotide kinase 3 phosphatase AAA_33 PF13671.6 CCF52098.1 - 3.5e-20 72.6 0.3 3e-10 40.4 0.3 2.9 2 1 1 3 3 3 2 AAA domain Zeta_toxin PF06414.12 CCF52098.1 - 3.6e-05 23.1 0.0 0.00014 21.3 0.0 1.9 2 1 0 2 2 2 1 Zeta toxin AAA_16 PF13191.6 CCF52098.1 - 0.00062 20.2 0.0 0.0011 19.4 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain SRPRB PF09439.10 CCF52098.1 - 0.011 15.2 0.0 0.025 14.0 0.0 1.6 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit KTI12 PF08433.10 CCF52098.1 - 0.015 14.8 4.4 0.12 11.9 2.1 2.2 1 1 1 2 2 2 0 Chromatin associated protein KTI12 MMR_HSR1 PF01926.23 CCF52098.1 - 0.036 14.1 0.0 0.089 12.9 0.0 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase 6PF2K PF01591.18 CCF52098.1 - 0.058 12.7 0.2 2 7.7 0.0 2.1 1 1 1 2 2 2 0 6-phosphofructo-2-kinase DUF4910 PF16254.5 CCF52098.1 - 0.072 11.9 0.0 0.11 11.3 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4910) Trehalase PF01204.18 CCF52099.1 - 3e-111 372.8 2.2 1.1e-100 337.9 0.0 2.1 2 0 0 2 2 2 2 Trehalase GDE_C PF06202.14 CCF52099.1 - 0.0012 17.9 0.3 0.0037 16.3 0.1 1.8 2 0 0 2 2 2 1 Amylo-alpha-1,6-glucosidase Bac_luciferase PF00296.20 CCF52102.1 - 1.2e-63 215.5 0.2 1.5e-63 215.1 0.2 1.1 1 0 0 1 1 1 1 Luciferase-like monooxygenase Mito_carr PF00153.27 CCF52103.1 - 4.3e-51 170.8 8.4 7.4e-17 61.1 0.2 4.2 3 1 0 3 3 3 3 Mitochondrial carrier protein TFR_dimer PF04253.15 CCF52104.1 - 4.8e-20 71.9 0.0 1.3e-19 70.4 0.0 1.8 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain Peptidase_M28 PF04389.17 CCF52104.1 - 5.7e-18 65.3 0.1 1.1e-17 64.4 0.1 1.4 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.22 CCF52104.1 - 1.8e-14 53.5 0.9 4.4e-14 52.3 0.9 1.7 1 0 0 1 1 1 1 PA domain Peptidase_M20 PF01546.28 CCF52104.1 - 0.097 12.4 0.0 0.16 11.6 0.0 1.4 1 0 0 1 1 1 0 Peptidase family M20/M25/M40 KdpC PF02669.15 CCF52104.1 - 0.13 12.1 0.1 0.27 11.1 0.1 1.4 1 0 0 1 1 1 0 K+-transporting ATPase, c chain Adaptin_N PF01602.20 CCF52104.1 - 0.19 10.3 0.0 0.3 9.6 0.0 1.2 1 0 0 1 1 1 0 Adaptin N terminal region Val_tRNA-synt_C PF10458.9 CCF52104.1 - 6.5 7.1 6.5 14 6.0 0.3 3.0 3 0 0 3 3 3 0 Valyl tRNA synthetase tRNA binding arm PALP PF00291.25 CCF52105.1 - 6.2e-53 180.1 0.2 2.2e-25 89.7 0.1 2.2 2 0 0 2 2 2 2 Pyridoxal-phosphate dependent enzyme LapA_dom PF06305.11 CCF52105.1 - 0.59 10.0 3.0 0.28 11.0 0.3 1.8 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain MRC1 PF09444.10 CCF52105.1 - 2.8 8.4 7.5 7.3 7.1 7.5 1.6 1 0 0 1 1 1 0 MRC1-like domain IMS PF00817.20 CCF52107.1 - 2.2e-38 131.6 0.0 4.2e-38 130.7 0.0 1.5 1 0 0 1 1 1 1 impB/mucB/samB family REV1_C PF16727.5 CCF52107.1 - 6.1e-17 61.8 0.3 1.2e-16 60.8 0.3 1.5 1 0 0 1 1 1 1 DNA repair protein REV1 C-terminal domain IMS_C PF11799.8 CCF52107.1 - 6.1e-10 39.8 0.0 1.7e-09 38.4 0.0 1.7 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain BRCT_2 PF16589.5 CCF52107.1 - 5.8e-06 26.6 0.0 2.8e-05 24.5 0.0 2.1 1 1 1 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain UBM PF14377.6 CCF52107.1 - 6.7e-05 22.2 7.2 0.27 10.7 0.3 4.0 3 0 0 3 3 3 2 Ubiquitin binding region BRCT PF00533.26 CCF52107.1 - 0.00027 21.3 0.0 0.00054 20.3 0.0 1.6 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain IMS_HHH PF11798.8 CCF52107.1 - 0.053 13.9 0.0 0.15 12.4 0.0 1.8 1 0 0 1 1 1 0 IMS family HHH motif DUF1805 PF08827.11 CCF52107.1 - 0.055 13.8 0.0 0.17 12.3 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF1805) PSI_PsaH PF03244.14 CCF52107.1 - 0.064 12.8 0.0 0.31 10.5 0.0 2.1 2 0 0 2 2 2 0 Photosystem I reaction centre subunit VI Aa_trans PF01490.18 CCF52108.1 - 9.1e-80 268.4 12.6 1.2e-79 268.0 12.6 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Pex14_N PF04695.13 CCF52108.1 - 0.033 14.8 0.4 0.084 13.5 0.1 1.9 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region YfhO PF09586.10 CCF52108.1 - 0.59 8.3 6.9 1.5 6.9 6.9 1.8 1 0 0 1 1 1 0 Bacterial membrane protein YfhO PalH PF08733.10 CCF52108.1 - 8.8 5.2 12.4 1.7 7.6 6.1 2.4 1 1 0 2 2 2 0 PalH/RIM21 PetN PF03742.14 CCF52109.1 - 0.042 13.7 0.2 0.042 13.7 0.2 2.2 2 1 1 3 3 3 0 PetN His_Phos_2 PF00328.22 CCF52110.1 - 5.9e-12 45.6 0.0 2.1e-05 24.1 0.0 2.6 1 1 1 2 2 2 2 Histidine phosphatase superfamily (branch 2) DUF4167 PF13763.6 CCF52110.1 - 0.1 12.7 0.0 0.25 11.5 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4167) DHHC PF01529.20 CCF52111.1 - 1.8e-30 105.7 0.2 1.8e-30 105.7 0.2 2.2 2 0 0 2 2 2 1 DHHC palmitoyltransferase TackOD1 PF18551.1 CCF52111.1 - 0.016 14.9 0.5 0.025 14.3 0.5 1.2 1 0 0 1 1 1 0 Thaumarchaeal output domain 1 DUF2754 PF10953.8 CCF52111.1 - 0.18 12.1 0.2 0.18 12.1 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2754) zf-C2HC5 PF06221.13 CCF52112.1 - 6.1e-18 64.6 3.9 9.9e-18 63.9 3.9 1.3 1 0 0 1 1 1 1 Putative zinc finger motif, C2HC5-type CX9C PF16860.5 CCF52113.1 - 4.6e-17 61.7 6.3 2.6e-13 49.8 0.4 2.3 2 1 0 2 2 2 2 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, CHCH PF06747.13 CCF52113.1 - 0.00057 19.9 1.9 0.027 14.6 0.3 2.9 2 1 1 3 3 3 2 CHCH domain UCR_hinge PF02320.16 CCF52113.1 - 0.00073 19.7 1.4 0.00073 19.7 1.4 3.0 1 1 2 3 3 3 1 Ubiquinol-cytochrome C reductase hinge protein Cmc1 PF08583.10 CCF52113.1 - 0.064 13.3 8.3 1 9.5 1.1 2.9 1 1 2 3 3 3 0 Cytochrome c oxidase biogenesis protein Cmc1 like COX17 PF05051.13 CCF52113.1 - 0.1 13.0 3.7 1.6 9.1 0.8 2.6 1 1 2 3 3 3 0 Cytochrome C oxidase copper chaperone (COX17) NDUF_B7 PF05676.13 CCF52113.1 - 0.16 11.7 2.2 2.8 7.7 0.3 2.4 1 1 1 2 2 2 0 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) COX6B PF02297.17 CCF52113.1 - 0.17 12.2 6.8 1.7 9.0 0.2 2.5 1 1 1 2 2 2 0 Cytochrome oxidase c subunit VIb MTCP1 PF08991.10 CCF52113.1 - 0.67 10.2 8.5 7.9 6.8 1.2 3.0 2 1 0 2 2 2 0 Mature-T-Cell Proliferation I type DUF3128 PF11326.8 CCF52113.1 - 5.5 7.4 8.5 40 4.7 3.9 3.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3128) GCSF PF16647.5 CCF52114.1 - 0.065 13.1 0.9 0.81 9.5 0.1 2.2 2 0 0 2 2 2 0 Granulocyte colony-stimulating factor Glyco_hydro_47 PF01532.20 CCF52115.1 - 1.8e-157 524.9 0.0 2.2e-157 524.6 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Urm1 PF09138.11 CCF52116.1 - 3.9e-33 113.7 0.0 4.4e-33 113.5 0.0 1.0 1 0 0 1 1 1 1 Urm1 (Ubiquitin related modifier) ThiS PF02597.20 CCF52116.1 - 0.00011 22.8 0.0 0.00013 22.5 0.0 1.3 1 0 0 1 1 1 1 ThiS family Castor_Poll_mid PF06241.12 CCF52116.1 - 0.029 14.3 0.0 0.038 14.0 0.0 1.3 1 0 0 1 1 1 0 Castor and Pollux, part of voltage-gated ion channel TrkA_C PF02080.21 CCF52116.1 - 0.046 13.6 0.1 0.069 13.0 0.1 1.4 1 0 0 1 1 1 0 TrkA-C domain DUF3290 PF11694.8 CCF52116.1 - 0.11 12.4 0.0 0.15 12.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3290) IQ PF00612.27 CCF52117.1 - 0.00012 21.6 0.7 0.00029 20.4 0.7 1.7 1 0 0 1 1 1 1 IQ calmodulin-binding motif SR-25 PF10500.9 CCF52117.1 - 0.0012 18.5 15.0 0.0012 18.5 15.0 2.6 2 0 0 2 2 2 1 Nuclear RNA-splicing-associated protein Opi1 PF08618.10 CCF52117.1 - 0.62 9.3 6.7 0.29 10.4 1.8 2.1 2 0 0 2 2 2 0 Transcription factor Opi1 DUF4100 PF13352.6 CCF52118.1 - 0.18 11.5 4.3 0.16 11.8 2.8 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF4100) ANAPC10 PF03256.16 CCF52119.1 - 0.07 12.8 0.1 0.1 12.2 0.1 1.2 1 0 0 1 1 1 0 Anaphase-promoting complex, subunit 10 (APC10) Comm PF15957.5 CCF52122.1 - 0.13 12.7 0.1 0.19 12.1 0.1 1.4 1 1 0 1 1 1 0 Commissureless MS_channel PF00924.18 CCF52123.1 - 1.3e-23 83.6 1.9 2.7e-23 82.6 1.9 1.5 1 0 0 1 1 1 1 Mechanosensitive ion channel EF-hand_1 PF00036.32 CCF52123.1 - 0.021 14.3 0.1 0.04 13.5 0.1 1.5 1 0 0 1 1 1 0 EF hand EF-hand_6 PF13405.6 CCF52123.1 - 0.11 12.5 0.0 0.23 11.5 0.0 1.5 1 0 0 1 1 1 0 EF-hand domain AMP-binding PF00501.28 CCF52124.1 - 2.5e-73 247.1 0.0 3.1e-73 246.8 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 CCF52124.1 - 1e-17 64.8 0.1 2.7e-17 63.5 0.1 1.8 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain MAPEG PF01124.18 CCF52125.1 - 1.2e-13 51.1 3.5 1.4e-13 50.9 3.5 1.1 1 0 0 1 1 1 1 MAPEG family Fe-ADH PF00465.19 CCF52126.1 - 4.6e-93 311.9 0.0 5.9e-93 311.6 0.0 1.1 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.6 CCF52126.1 - 3.2e-12 46.7 0.0 1.8e-09 37.7 0.0 2.2 2 0 0 2 2 2 2 Iron-containing alcohol dehydrogenase HDC PF02329.16 CCF52127.1 - 0.083 11.9 0.0 0.12 11.4 0.0 1.2 1 0 0 1 1 1 0 Histidine carboxylase PI chain Aldo_ket_red PF00248.21 CCF52128.1 - 2.3e-41 141.9 0.0 6e-39 134.0 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family LSDAT_euk PF18139.1 CCF52128.1 - 0.13 11.6 0.0 0.22 10.9 0.0 1.3 1 0 0 1 1 1 0 SLOG in TRPM DUF294_C PF10335.9 CCF52130.1 - 0.015 15.1 3.2 0.014 15.2 2.6 1.3 1 1 0 1 1 1 0 Putative nucleotidyltransferase substrate binding domain adh_short_C2 PF13561.6 CCF52131.1 - 6.2e-50 169.9 0.0 8.8e-50 169.4 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCF52131.1 - 4.2e-47 160.1 0.0 5.6e-47 159.7 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CCF52131.1 - 9.6e-09 35.4 0.0 1.3e-08 35.0 0.0 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CCF52131.1 - 0.0061 16.1 0.0 0.012 15.1 0.0 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CCF52131.1 - 0.065 12.6 0.0 0.1 12.0 0.0 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase ADK PF00406.22 CCF52132.1 - 6.7e-46 156.1 0.0 8.5e-46 155.8 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 CCF52132.1 - 2.8e-23 82.8 0.0 6.9e-23 81.6 0.0 1.6 2 0 0 2 2 2 1 AAA domain ADK_lid PF05191.14 CCF52132.1 - 1.9e-12 46.9 0.0 3.8e-12 46.0 0.0 1.5 1 0 0 1 1 1 1 Adenylate kinase, active site lid AAA_18 PF13238.6 CCF52132.1 - 1.5e-05 25.5 0.0 4.1e-05 24.1 0.0 1.6 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 CCF52132.1 - 0.00011 22.4 0.1 0.0011 19.2 0.1 2.3 1 1 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 CCF52132.1 - 0.0023 17.3 0.0 0.099 11.9 0.0 2.3 2 0 0 2 2 2 1 Zeta toxin C6 PF01681.17 CCF52132.1 - 0.026 15.0 0.7 9 6.9 0.6 2.2 2 0 0 2 2 2 0 C6 domain 6PF2K PF01591.18 CCF52132.1 - 0.23 10.7 0.0 8.8 5.6 0.0 2.4 3 0 0 3 3 3 0 6-phosphofructo-2-kinase Ion_trans_2 PF07885.16 CCF52133.1 - 2.2e-30 104.5 33.5 7.7e-16 57.8 10.1 3.4 4 0 0 4 4 4 2 Ion channel Ion_trans PF00520.31 CCF52133.1 - 0.00019 20.8 17.7 0.00019 20.7 2.4 2.5 3 0 0 3 3 3 2 Ion transport protein DUF2852 PF11014.8 CCF52133.1 - 0.16 12.1 0.7 13 5.9 0.0 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF2852) HemY_N PF07219.13 CCF52133.1 - 1.3 9.3 11.3 1.8 8.8 0.0 4.4 4 0 0 4 4 4 0 HemY protein N-terminus YfhO PF09586.10 CCF52133.1 - 1.7 6.8 6.5 2.5 6.2 5.1 1.8 2 0 0 2 2 2 0 Bacterial membrane protein YfhO DUF4834 PF16118.5 CCF52133.1 - 2.1 9.3 0.0 2.1 9.3 0.0 3.6 3 1 0 3 3 3 0 Domain of unknown function (DUF4834) Cas_Csy4 PF09618.10 CCF52133.1 - 8.5 6.5 8.4 4.3 7.4 0.2 2.7 3 0 0 3 3 3 0 CRISPR-associated protein (Cas_Csy4) RVT_1 PF00078.27 CCF52137.1 - 1.9e-09 37.3 0.2 0.00037 20.1 0.0 2.2 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) Sulfate_transp PF00916.20 CCF52141.1 - 2.1e-110 369.0 18.8 2.7e-110 368.7 18.8 1.1 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 CCF52141.1 - 1.6e-10 40.6 0.0 3.5e-10 39.5 0.0 1.5 1 0 0 1 1 1 1 STAS domain MFS_MOT1 PF16983.5 CCF52141.1 - 0.00023 21.5 11.7 0.00044 20.6 1.7 2.8 2 0 0 2 2 2 2 Molybdate transporter of MFS superfamily Creatinase_N_2 PF16189.5 CCF52143.1 - 1.2e-46 158.7 0.0 3.1e-45 154.2 0.0 2.6 3 0 0 3 3 3 1 Creatinase/Prolidase N-terminal domain Peptidase_M24 PF00557.24 CCF52143.1 - 6.1e-43 146.9 0.0 8.6e-43 146.5 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 Peptidase_M24_C PF16188.5 CCF52143.1 - 1.6e-22 79.4 0.1 1e-21 76.7 0.0 2.3 2 0 0 2 2 2 1 C-terminal region of peptidase_M24 Creatinase_N PF01321.18 CCF52143.1 - 5.3e-21 75.7 0.0 7.9e-19 68.6 0.0 2.5 2 0 0 2 2 2 1 Creatinase/Prolidase N-terminal domain AdoHcyase PF05221.17 CCF52144.1 - 2.5e-132 440.6 0.0 2.7e-74 250.0 0.1 2.0 1 1 1 2 2 2 2 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.21 CCF52144.1 - 8.6e-85 282.8 1.4 1.4e-84 282.0 1.4 1.4 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.19 CCF52144.1 - 2.3e-10 40.1 0.1 7.6e-10 38.4 0.0 1.8 1 1 1 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.12 CCF52144.1 - 0.00051 19.7 0.1 0.00082 19.0 0.1 1.4 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain TrkA_N PF02254.18 CCF52144.1 - 0.0047 17.2 0.0 0.011 16.0 0.0 1.6 1 0 0 1 1 1 1 TrkA-N domain Shikimate_DH PF01488.20 CCF52144.1 - 0.094 12.8 0.0 0.19 11.8 0.0 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase THF_DHG_CYH_C PF02882.19 CCF52144.1 - 0.097 12.0 0.3 0.43 9.9 0.3 2.1 1 1 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain NAD_binding_7 PF13241.6 CCF52144.1 - 0.14 12.6 0.1 0.44 11.0 0.1 1.8 2 0 0 2 2 2 0 Putative NAD(P)-binding Septin PF00735.18 CCF52145.1 - 4.7e-123 410.0 0.5 7.9e-123 409.2 0.5 1.3 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 CCF52145.1 - 8.9e-09 35.4 0.0 2.8e-08 33.9 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CCF52145.1 - 9.2e-07 28.9 0.3 9.5e-05 22.4 0.1 2.7 2 1 0 2 2 2 1 RsgA GTPase GTP_EFTU PF00009.27 CCF52145.1 - 2.4e-05 24.0 1.9 0.0017 18.0 0.0 3.0 2 2 0 2 2 2 1 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 CCF52145.1 - 0.00041 20.4 1.8 0.13 12.3 0.0 3.1 2 1 0 3 3 3 1 Dynamin family Ras PF00071.22 CCF52145.1 - 0.00082 19.0 1.5 0.0077 15.8 0.0 2.7 2 1 0 2 2 2 1 Ras family AIG1 PF04548.16 CCF52145.1 - 0.0022 17.4 2.0 0.0036 16.6 0.0 2.4 3 1 1 4 4 4 1 AIG1 family AAA_22 PF13401.6 CCF52145.1 - 0.0042 17.4 2.5 0.011 16.0 0.0 2.7 3 2 0 3 3 3 1 AAA domain AAA_16 PF13191.6 CCF52145.1 - 0.0076 16.6 0.2 0.026 14.9 0.0 1.9 2 0 0 2 2 2 1 AAA ATPase domain ABC_tran PF00005.27 CCF52145.1 - 0.0099 16.4 8.3 0.026 15.1 0.8 2.6 2 1 0 2 2 2 1 ABC transporter Roc PF08477.13 CCF52145.1 - 0.013 15.8 0.0 0.051 13.8 0.0 2.1 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_29 PF13555.6 CCF52145.1 - 0.013 15.2 0.0 0.025 14.3 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain PduV-EutP PF10662.9 CCF52145.1 - 0.12 12.1 0.4 14 5.4 0.0 3.3 3 1 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation Exonuc_VII_L PF02601.15 CCF52145.1 - 0.3 10.6 7.1 0.63 9.6 7.1 1.5 1 0 0 1 1 1 0 Exonuclease VII, large subunit AAA_23 PF13476.6 CCF52145.1 - 0.96 9.9 11.5 23 5.4 11.5 2.4 1 1 0 1 1 1 0 AAA domain OmpH PF03938.14 CCF52145.1 - 1.1 9.5 10.4 2.5 8.4 10.4 1.6 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) AAA_11 PF13086.6 CCF52145.1 - 2 8.1 6.4 2.5 7.8 4.1 2.0 2 0 0 2 2 2 0 AAA domain Strep_SA_rep PF06696.11 CCF52145.1 - 6.6 6.9 6.6 4.4 7.4 0.3 2.7 1 1 1 2 2 2 0 Streptococcal surface antigen repeat Tht1 PF04163.12 CCF52146.1 - 4.3e-07 29.1 4.4 5.5e-05 22.1 0.9 2.1 1 1 1 2 2 2 2 Tht1-like nuclear fusion protein DUF720 PF05302.11 CCF52146.1 - 0.0044 16.9 0.2 0.013 15.4 0.2 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF720) Spc42p PF11544.8 CCF52146.1 - 0.063 13.3 0.1 0.19 11.8 0.1 1.7 1 0 0 1 1 1 0 Spindle pole body component Spc42p GAS PF13851.6 CCF52146.1 - 0.064 12.6 1.8 0.092 12.1 0.2 1.7 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding MRG PF05712.13 CCF52147.1 - 9.2e-59 198.1 0.0 1.3e-58 197.6 0.0 1.2 1 0 0 1 1 1 1 MRG Tudor-knot PF11717.8 CCF52147.1 - 8.4e-11 41.6 0.2 1.8e-10 40.6 0.2 1.6 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Macoilin PF09726.9 CCF52147.1 - 0.034 12.7 0.8 0.039 12.5 0.8 1.1 1 0 0 1 1 1 0 Macoilin family CCDC106 PF15794.5 CCF52147.1 - 0.5 10.0 5.0 0.77 9.4 5.0 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 AMP-binding PF00501.28 CCF52148.1 - 1.8e-89 300.2 0.0 2.5e-89 299.8 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 CCF52148.1 - 0.012 16.5 0.0 0.034 15.1 0.0 1.8 1 0 0 1 1 1 0 AMP-binding enzyme C-terminal domain PH_12 PF16457.5 CCF52148.1 - 0.15 12.6 0.1 0.29 11.7 0.1 1.4 1 0 0 1 1 1 0 Pleckstrin homology domain Sec63 PF02889.16 CCF52149.1 - 8.9e-149 493.7 0.2 5.6e-82 274.8 0.0 2.3 2 0 0 2 2 2 2 Sec63 Brl domain DEAD PF00270.29 CCF52149.1 - 4.1e-45 153.7 0.0 1.4e-25 90.1 0.0 2.6 2 0 0 2 2 2 2 DEAD/DEAH box helicase Helicase_PWI PF18149.1 CCF52149.1 - 6.7e-40 135.7 0.4 6.7e-40 135.7 0.4 2.3 2 0 0 2 2 2 1 N-terminal helicase PWI domain ResIII PF04851.15 CCF52149.1 - 7e-23 81.5 0.0 2.9e-15 56.7 0.0 2.5 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit Helicase_C PF00271.31 CCF52149.1 - 3.3e-13 50.0 0.0 5e-07 30.1 0.0 3.8 2 1 0 2 2 2 2 Helicase conserved C-terminal domain AAA_30 PF13604.6 CCF52149.1 - 6.9e-06 25.9 0.0 0.018 14.8 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 CCF52149.1 - 9.9e-05 22.6 0.6 0.035 14.4 0.0 3.8 4 1 0 4 4 4 1 AAA domain PhoH PF02562.16 CCF52149.1 - 0.069 12.6 0.0 1.2 8.6 0.0 2.4 2 0 0 2 2 2 0 PhoH-like protein PHD PF00628.29 CCF52150.1 - 1.8e-06 27.7 14.6 3.2e-06 26.9 14.6 1.4 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 CCF52150.1 - 0.00063 19.3 6.0 0.0011 18.4 6.0 1.4 1 0 0 1 1 1 1 PHD-finger Stc1 PF12898.7 CCF52150.1 - 0.41 11.2 5.3 1.1 9.8 5.3 1.8 1 0 0 1 1 1 0 Stc1 domain Cnd1 PF12717.7 CCF52151.1 - 2e-06 27.9 6.3 0.0095 16.0 0.1 5.7 6 1 1 7 7 7 2 non-SMC mitotic condensation complex subunit 1 RNA_pol_3_Rpc31 PF11705.8 CCF52151.1 - 7e-05 23.2 3.2 0.00013 22.3 3.2 1.5 1 0 0 1 1 1 1 DNA-directed RNA polymerase III subunit Rpc31 Anticodon_1 PF08264.13 CCF52151.1 - 0.0004 20.4 0.1 0.022 14.7 0.0 2.8 2 0 0 2 2 2 1 Anticodon-binding domain of tRNA HEAT_2 PF13646.6 CCF52151.1 - 0.0011 19.3 2.6 0.031 14.6 0.2 6.5 7 2 1 9 9 9 2 HEAT repeats HEAT PF02985.22 CCF52151.1 - 0.022 15.0 6.1 34 5.0 0.0 5.7 5 0 0 5 5 5 0 HEAT repeat UNC45-central PF11701.8 CCF52151.1 - 1.7 8.6 5.2 2.7 8.0 0.2 3.7 5 0 0 5 5 5 0 Myosin-binding striated muscle assembly central HEAT_EZ PF13513.6 CCF52151.1 - 2.1 9.0 8.6 1.2 9.8 0.1 4.5 4 1 1 5 5 5 0 HEAT-like repeat Pox_Ag35 PF03286.14 CCF52151.1 - 2.1 8.1 10.1 5.2 6.8 10.1 1.7 1 0 0 1 1 1 0 Pox virus Ag35 surface protein PBP1_TM PF14812.6 CCF52151.1 - 6.8 7.1 8.3 18 5.8 8.3 1.6 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal zf-MYND PF01753.18 CCF52152.1 - 2.3e-10 40.4 12.9 2.3e-10 40.4 12.9 3.4 3 2 1 4 4 4 1 MYND finger SET PF00856.28 CCF52152.1 - 1e-08 35.8 0.0 2.6e-08 34.5 0.0 1.9 1 1 0 1 1 1 1 SET domain Phage_tail_APC PF16778.5 CCF52152.1 - 0.067 13.1 0.7 0.19 11.6 0.7 1.7 1 0 0 1 1 1 0 Phage tail assembly chaperone protein Aminotran_1_2 PF00155.21 CCF52154.1 - 5.1e-37 127.9 0.0 1.1e-36 126.8 0.0 1.4 2 0 0 2 2 2 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 CCF52154.1 - 0.053 12.8 0.0 0.09 12.1 0.0 1.3 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family CHCH PF06747.13 CCF52155.1 - 1.3e-09 37.9 3.9 1.9e-09 37.4 3.9 1.2 1 0 0 1 1 1 1 CHCH domain NDUF_B7 PF05676.13 CCF52155.1 - 0.014 15.1 0.8 0.021 14.6 0.8 1.2 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) Cmc1 PF08583.10 CCF52155.1 - 0.029 14.4 0.8 0.047 13.7 0.8 1.3 1 0 0 1 1 1 0 Cytochrome c oxidase biogenesis protein Cmc1 like CX9C PF16860.5 CCF52155.1 - 0.033 14.2 4.4 0.054 13.5 4.4 1.3 1 0 0 1 1 1 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, Pet191_N PF10203.9 CCF52155.1 - 0.061 13.6 5.6 0.9 9.9 5.6 2.1 1 1 0 1 1 1 0 Cytochrome c oxidase assembly protein PET191 COX17 PF05051.13 CCF52155.1 - 0.32 11.4 4.8 1.8 9.0 0.9 2.3 1 1 1 2 2 2 0 Cytochrome C oxidase copper chaperone (COX17) Actin PF00022.19 CCF52156.1 - 1.1e-34 119.8 0.0 1.1e-33 116.5 0.0 2.4 1 1 0 1 1 1 1 Actin Gln-synt_C PF00120.24 CCF52161.1 - 8.4e-72 242.0 0.1 6.6e-71 239.1 0.1 1.9 1 1 0 1 1 1 1 Glutamine synthetase, catalytic domain Aldedh PF00171.22 CCF52162.1 - 4.3e-124 414.5 0.1 5.1e-124 414.3 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.14 CCF52162.1 - 0.003 16.7 0.0 0.016 14.3 0.0 2.1 1 1 0 1 1 1 1 Acyl-CoA reductase (LuxC) adh_short_C2 PF13561.6 CCF52163.1 - 4.4e-64 216.2 0.4 5.7e-64 215.9 0.4 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCF52163.1 - 1.4e-44 151.9 0.3 1.7e-44 151.6 0.3 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CCF52163.1 - 1.9e-07 31.2 0.5 3.6e-07 30.3 0.5 1.5 1 1 0 1 1 1 1 KR domain 3HCDH_N PF02737.18 CCF52163.1 - 0.0022 17.9 0.1 0.0089 15.9 0.1 1.9 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain GIDA PF01134.22 CCF52163.1 - 0.11 11.5 0.7 0.15 11.1 0.7 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A FAD_binding_3 PF01494.19 CCF52164.1 - 1.4e-19 70.6 0.1 2.6e-19 69.7 0.1 1.4 1 1 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 CCF52164.1 - 1.3e-05 25.3 0.3 5.7e-05 23.3 0.3 2.2 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CCF52164.1 - 4.9e-05 22.7 0.2 0.00032 20.1 0.1 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 CCF52164.1 - 0.00011 21.4 0.3 0.00014 21.0 0.3 1.1 1 0 0 1 1 1 1 Lycopene cyclase protein FAD_binding_2 PF00890.24 CCF52164.1 - 0.00052 19.2 2.4 0.0016 17.6 1.4 2.3 2 1 1 3 3 3 1 FAD binding domain DAO PF01266.24 CCF52164.1 - 0.00066 19.4 0.0 0.001 18.8 0.0 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_oxidored PF12831.7 CCF52164.1 - 0.00073 19.0 0.1 0.001 18.5 0.1 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase ApbA PF02558.16 CCF52164.1 - 0.014 15.0 0.4 1.6 8.3 0.0 2.4 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA Trp_halogenase PF04820.14 CCF52164.1 - 0.08 11.8 0.5 0.75 8.6 0.3 2.3 3 0 0 3 3 3 0 Tryptophan halogenase Pyr_redox PF00070.27 CCF52164.1 - 0.095 13.3 0.5 0.35 11.4 0.5 2.0 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CCF52164.1 - 0.18 10.5 0.2 0.35 9.5 0.2 1.5 1 0 0 1 1 1 0 HI0933-like protein GIDA PF01134.22 CCF52164.1 - 0.2 10.7 1.2 0.34 10.0 1.2 1.4 1 0 0 1 1 1 0 Glucose inhibited division protein A EthD PF07110.11 CCF52165.1 - 2e-17 64.1 0.2 2.6e-17 63.8 0.2 1.1 1 0 0 1 1 1 1 EthD domain MmlI PF09448.10 CCF52165.1 - 0.026 15.0 0.1 0.045 14.2 0.1 1.7 1 1 0 1 1 1 0 Methylmuconolactone methyl-isomerase COesterase PF00135.28 CCF52166.1 - 9.2e-85 285.4 0.6 1.2e-84 285.1 0.6 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 CCF52166.1 - 6.9e-08 32.6 2.1 3.4e-07 30.3 0.8 2.3 2 1 0 2 2 2 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 CCF52166.1 - 0.17 11.3 0.7 0.8 9.1 0.2 1.9 1 1 1 2 2 2 0 Prolyl oligopeptidase family RVT_2 PF07727.14 CCF52167.1 - 5e-29 101.7 0.2 6.5e-29 101.3 0.2 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Acetyltransf_1 PF00583.25 CCF52169.1 - 1.7e-08 34.7 0.0 3e-08 33.9 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CCF52169.1 - 2.1e-08 34.1 0.0 5.1e-08 32.9 0.0 1.6 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CCF52169.1 - 6.4e-07 29.7 0.1 1.4e-06 28.7 0.1 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 CCF52169.1 - 0.014 15.4 0.2 0.043 13.9 0.1 1.9 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain DUF3422 PF11902.8 CCF52169.1 - 0.022 13.9 0.4 0.035 13.2 0.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3422) RsmF_methylt_CI PF17126.5 CCF52169.1 - 1.2 9.2 3.7 2.5 8.2 0.1 2.6 3 0 0 3 3 3 0 RsmF rRNA methyltransferase first C-terminal domain MFS_1 PF07690.16 CCF52170.1 - 7.5e-25 87.6 74.5 2.6e-18 66.1 42.5 2.5 1 1 2 3 3 3 2 Major Facilitator Superfamily ADH_N PF08240.12 CCF52171.1 - 1.8e-20 72.8 1.5 4.2e-20 71.7 1.5 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CCF52171.1 - 1.9e-16 60.2 0.0 2.7e-15 56.5 0.0 2.6 2 1 1 3 3 3 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 CCF52171.1 - 2.2e-05 23.9 0.0 3.6e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.21 CCF52171.1 - 0.00041 19.7 0.1 0.00076 18.8 0.1 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_2 PF03446.15 CCF52171.1 - 0.00056 20.1 0.1 0.0015 18.7 0.0 1.7 1 1 1 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase Shikimate_DH PF01488.20 CCF52171.1 - 0.0013 18.8 0.0 0.0036 17.4 0.0 1.7 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase ApbA PF02558.16 CCF52171.1 - 0.0016 18.1 0.0 0.0036 17.0 0.0 1.6 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA NAD_binding_7 PF13241.6 CCF52171.1 - 0.01 16.3 0.0 0.022 15.2 0.0 1.6 1 0 0 1 1 1 1 Putative NAD(P)-binding 3HCDH_N PF02737.18 CCF52171.1 - 0.029 14.3 0.1 0.059 13.3 0.0 1.5 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain IGFBP PF00219.18 CCF52171.1 - 0.037 14.7 0.4 0.075 13.7 0.4 1.4 1 0 0 1 1 1 0 Insulin-like growth factor binding protein GFO_IDH_MocA PF01408.22 CCF52171.1 - 0.052 14.4 0.2 0.66 10.8 0.0 2.1 2 0 0 2 2 2 0 Oxidoreductase family, NAD-binding Rossmann fold ThiF PF00899.21 CCF52171.1 - 0.27 10.5 1.5 0.55 9.5 1.5 1.4 1 0 0 1 1 1 0 ThiF family LCCL PF03815.19 CCF52172.1 - 8e-18 64.3 0.1 1.6e-17 63.4 0.1 1.5 1 0 0 1 1 1 1 LCCL domain DUF1308 PF07000.11 CCF52172.1 - 0.00067 19.6 0.0 0.87 9.5 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF1308) Glypican PF01153.19 CCF52172.1 - 0.13 11.0 0.4 0.22 10.3 0.4 1.2 1 0 0 1 1 1 0 Glypican COA2 PF17051.5 CCF52173.1 - 0.012 15.7 0.7 0.018 15.1 0.7 1.5 1 1 0 1 1 1 0 Cytochrome C oxidase assembly factor 2 AFP_2 PF18815.1 CCF52174.1 - 0.35 11.2 1.8 0.77 10.1 0.2 2.2 2 0 0 2 2 2 0 Bacterial antifreeze protein repeat RVT_2 PF07727.14 CCF52175.1 - 1.2e-12 48.0 0.0 1.7e-12 47.5 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Sod_Ni PF09055.11 CCF52176.1 - 0.64 10.6 2.8 4 8.0 0.2 2.4 2 1 0 2 2 2 0 Nickel-containing superoxide dismutase FAD_binding_4 PF01565.23 CCF52177.1 - 6.4e-24 84.3 0.1 1.1e-23 83.5 0.1 1.4 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 CCF52177.1 - 9.3e-14 51.3 0.0 1.8e-13 50.4 0.0 1.5 1 0 0 1 1 1 1 Berberine and berberine like Asp_Glu_race PF01177.22 CCF52178.1 - 2.1e-07 31.0 0.1 6.8e-06 26.1 0.1 2.0 1 1 0 1 1 1 1 Asp/Glu/Hydantoin racemase Amdase PF17645.1 CCF52178.1 - 0.02 14.5 0.5 0.061 12.9 0.2 1.9 1 1 0 1 1 1 0 Arylmalonate decarboxylase AroM PF07302.11 CCF52178.1 - 0.09 12.2 0.5 0.31 10.4 0.1 1.9 1 1 1 2 2 2 0 AroM protein T2SSM PF04612.12 CCF52179.1 - 1.6 8.8 11.1 1.3 9.0 2.1 3.1 3 0 0 3 3 3 0 Type II secretion system (T2SS), protein M RXLR PF16810.5 CCF52179.1 - 4.4 7.7 7.3 89 3.5 7.3 2.8 1 1 0 1 1 1 0 RXLR phytopathogen effector protein, Avirulence activity WD40 PF00400.32 CCF52180.1 - 2.2e-33 113.7 22.1 8.8e-06 26.4 0.1 11.6 11 0 0 11 11 11 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF52180.1 - 2.7e-13 50.0 3.1 0.022 15.1 0.0 7.1 4 4 4 8 8 8 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CCF52180.1 - 2.5e-08 33.3 3.7 0.045 12.7 0.1 4.2 3 1 1 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nbas_N PF15492.6 CCF52180.1 - 0.00034 20.0 2.8 0.28 10.5 0.0 3.9 3 1 1 4 4 4 2 Neuroblastoma-amplified sequence, N terminal Lgl_C PF08596.10 CCF52180.1 - 0.00049 18.9 0.3 0.0064 15.2 0.2 2.1 2 0 0 2 2 2 1 Lethal giant larvae(Lgl) like, C-terminal PD40 PF07676.12 CCF52180.1 - 0.16 11.9 0.2 64 3.7 0.0 3.7 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat IceA2 PF05862.11 CCF52180.1 - 1 9.3 3.6 3.9 7.5 0.1 3.5 4 1 0 4 4 4 0 Helicobacter pylori IceA2 protein ABC_tran PF00005.27 CCF52181.1 - 1.2e-17 64.8 0.0 4.8e-12 46.6 0.0 2.7 2 1 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 CCF52181.1 - 9.2e-08 32.2 1.8 0.052 13.3 0.0 3.3 3 0 0 3 3 3 3 AAA domain, putative AbiEii toxin, Type IV TA system SbcCD_C PF13558.6 CCF52181.1 - 0.00069 19.8 0.0 0.35 11.1 0.0 2.7 2 0 0 2 2 2 2 Putative exonuclease SbcCD, C subunit AAA_29 PF13555.6 CCF52181.1 - 0.00073 19.2 0.1 0.0017 18.1 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain NACHT PF05729.12 CCF52181.1 - 0.0016 18.4 0.0 0.005 16.8 0.0 1.9 1 1 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 CCF52181.1 - 0.037 14.4 2.9 0.096 13.1 0.3 2.5 2 1 0 2 2 2 0 AAA ATPase domain DAP3 PF10236.9 CCF52181.1 - 0.062 12.5 0.0 0.11 11.6 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 AAA_23 PF13476.6 CCF52181.1 - 0.077 13.5 0.0 0.16 12.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain SMC_N PF02463.19 CCF52181.1 - 0.11 11.9 0.1 0.67 9.4 0.0 2.0 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain PARG_cat PF05028.14 CCF52181.1 - 0.2 10.9 0.0 0.5 9.6 0.0 1.6 2 0 0 2 2 2 0 Poly (ADP-ribose) glycohydrolase (PARG) MBOAT_2 PF13813.6 CCF52182.1 - 2.5e-05 24.5 3.5 0.0019 18.4 0.1 3.3 3 0 0 3 3 3 2 Membrane bound O-acyl transferase family ECF_trnsprt PF12822.7 CCF52182.1 - 2.7 8.1 7.9 4.7 7.3 1.4 2.8 2 1 0 2 2 2 0 ECF transporter, substrate-specific component RVT_2 PF07727.14 CCF52184.1 - 1.3e-14 54.5 0.0 1.7e-14 54.1 0.0 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) La PF05383.17 CCF52184.1 - 0.085 12.9 0.0 0.13 12.3 0.0 1.2 1 0 0 1 1 1 0 La domain rve PF00665.26 CCF52185.1 - 2.7e-07 30.8 0.0 5e-07 29.9 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain zf-ribbon_3 PF13248.6 CCF52186.1 - 0.0085 15.5 0.3 0.018 14.5 0.3 1.6 1 0 0 1 1 1 1 zinc-ribbon domain TPT PF03151.16 CCF52188.1 - 1.6e-53 181.9 8.6 3.3e-53 180.9 8.6 1.5 1 1 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 CCF52188.1 - 1.5e-13 51.1 23.4 2.5e-08 34.2 9.9 2.8 2 1 0 2 2 2 2 EamA-like transporter family UAA PF08449.11 CCF52188.1 - 1.9e-07 30.6 15.0 2.5e-06 26.9 15.0 2.1 1 1 0 1 1 1 1 UAA transporter family Nuc_sug_transp PF04142.15 CCF52188.1 - 0.017 14.3 10.4 0.05 12.8 1.5 2.6 2 1 0 2 2 2 0 Nucleotide-sugar transporter Multi_Drug_Res PF00893.19 CCF52188.1 - 0.024 15.3 2.6 0.024 15.3 2.6 2.3 2 0 0 2 2 2 0 Small Multidrug Resistance protein PMT_4TMC PF16192.5 CCF52188.1 - 4.7 6.7 9.7 1.3 8.6 3.6 2.7 3 0 0 3 3 3 0 C-terminal four TMM region of protein-O-mannosyltransferase TMEM234 PF10639.9 CCF52188.1 - 5.1 7.2 7.9 2.7 8.0 0.8 2.5 2 0 0 2 2 2 0 Putative transmembrane family 234 UQ_con PF00179.26 CCF52189.1 - 1.9e-15 56.8 0.0 5.1e-15 55.3 0.0 1.7 1 1 0 1 1 1 1 Ubiquitin-conjugating enzyme RAI1 PF08652.11 CCF52190.1 - 3.2e-20 72.1 0.0 6.9e-20 71.0 0.0 1.6 1 0 0 1 1 1 1 RAI1 like PD-(D/E)XK nuclease CoA_transf_3 PF02515.17 CCF52191.1 - 7.4e-64 216.2 0.0 2.8e-63 214.3 0.0 1.7 1 1 0 1 1 1 1 CoA-transferase family III ELO PF01151.18 CCF52192.1 - 9.7e-55 185.8 18.4 1.3e-54 185.4 18.4 1.1 1 0 0 1 1 1 1 GNS1/SUR4 family EAL PF00563.20 CCF52192.1 - 0.1 12.1 0.0 0.15 11.6 0.0 1.2 1 0 0 1 1 1 0 EAL domain DUF2312 PF10073.9 CCF52193.1 - 0.17 11.6 0.0 0.27 10.9 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2312) zf-C2H2 PF00096.26 CCF52195.1 - 4e-06 27.0 7.3 0.0021 18.4 0.9 3.0 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 CCF52195.1 - 0.0065 16.9 0.4 0.0065 16.9 0.4 3.6 4 0 0 4 4 4 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 CCF52195.1 - 0.016 16.0 0.6 0.016 16.0 0.6 3.7 4 0 0 4 4 4 0 C2H2-type zinc finger DUF3493 PF11998.8 CCF52195.1 - 0.027 14.6 0.0 0.057 13.6 0.0 1.5 1 0 0 1 1 1 0 Low psii accumulation1 / Rep27 Zn_ribbon_SprT PF17283.2 CCF52195.1 - 0.03 14.2 0.1 0.11 12.4 0.1 1.9 1 0 0 1 1 1 0 SprT-like zinc ribbon domain adh_short PF00106.25 CCF52196.1 - 1.4e-32 112.7 0.0 2e-32 112.2 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF52196.1 - 1.6e-23 83.5 0.0 3.5e-23 82.4 0.0 1.4 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF52196.1 - 1.5e-05 25.0 2.8 0.0003 20.7 2.8 2.6 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 CCF52196.1 - 0.00066 19.2 0.0 0.0009 18.8 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family UPF0146 PF03686.13 CCF52196.1 - 0.0017 18.3 0.1 0.0027 17.6 0.1 1.3 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0146) YjeF_N PF03853.15 CCF52196.1 - 0.0085 16.0 0.0 0.013 15.4 0.0 1.2 1 0 0 1 1 1 1 YjeF-related protein N-terminus 2-Hacid_dh_C PF02826.19 CCF52196.1 - 0.0086 15.5 0.1 0.03 13.7 0.0 1.8 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 3HCDH_N PF02737.18 CCF52196.1 - 0.029 14.3 0.1 0.045 13.6 0.1 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain GDP_Man_Dehyd PF16363.5 CCF52196.1 - 0.033 13.6 0.1 0.053 12.9 0.1 1.3 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 CCF52196.1 - 0.048 13.5 0.0 0.072 13.0 0.0 1.3 1 0 0 1 1 1 0 NAD(P)H-binding 3Beta_HSD PF01073.19 CCF52196.1 - 0.089 11.8 0.1 0.12 11.3 0.1 1.1 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family DEDD_Tnp_IS110 PF01548.17 CCF52196.1 - 0.094 12.6 0.0 0.15 11.9 0.0 1.3 1 0 0 1 1 1 0 Transposase DFP PF04127.15 CCF52196.1 - 0.11 12.3 0.0 0.18 11.6 0.0 1.3 1 0 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein FAD_binding_3 PF01494.19 CCF52196.1 - 0.2 10.9 0.7 0.31 10.3 0.7 1.2 1 0 0 1 1 1 0 FAD binding domain RVT_2 PF07727.14 CCF52198.1 - 1.7e-24 86.8 0.0 2e-24 86.5 0.0 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) gag_pre-integrs PF13976.6 CCF52200.1 - 1.5e-05 24.8 0.1 4.3e-05 23.3 0.1 1.8 1 0 0 1 1 1 1 GAG-pre-integrase domain Plasmod_dom_1 PF09715.10 CCF52200.1 - 0.031 14.3 0.6 0.1 12.7 0.6 1.9 1 0 0 1 1 1 0 Plasmodium protein of unknown function (Plasmod_dom_1) Integrase_H2C2 PF17921.1 CCF52200.1 - 0.35 11.0 2.3 0.44 10.7 0.1 2.3 2 0 0 2 2 2 0 Integrase zinc binding domain FXMRP1_C_core PF12235.8 CCF52200.1 - 3.7 8.2 8.3 0.16 12.7 2.4 1.6 2 0 0 2 2 2 0 Fragile X-related 1 protein core C terminal Methyltransf_11 PF08241.12 CCF52201.1 - 1.2e-16 61.2 0.0 2.6e-16 60.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF52201.1 - 5.5e-14 52.6 0.0 4.4e-13 49.8 0.0 2.4 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF52201.1 - 3.3e-06 27.8 0.0 1.6e-05 25.6 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF52201.1 - 0.00017 21.4 0.0 0.00074 19.3 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCF52201.1 - 0.00026 20.9 0.0 0.00056 19.8 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CCF52201.1 - 0.0019 17.6 0.0 0.0038 16.6 0.0 1.5 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family DUF4210 PF13915.6 CCF52202.1 - 6.3e-29 100.4 0.1 2e-28 98.7 0.1 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF4210) Chromosome_seg PF13889.6 CCF52202.1 - 4.9e-22 77.8 0.0 9.6e-22 76.9 0.0 1.5 1 0 0 1 1 1 1 Chromosome segregation during meiosis ECH_1 PF00378.20 CCF52206.1 - 3e-45 154.5 0.4 2.7e-26 92.4 0.3 2.5 2 1 0 2 2 2 2 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 CCF52206.1 - 1e-25 91.0 2.8 5.8e-24 85.2 0.7 2.6 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase Pmp3 PF01679.17 CCF52207.1 - 5.3e-25 87.4 11.5 6.6e-25 87.1 11.5 1.1 1 0 0 1 1 1 1 Proteolipid membrane potential modulator SNARE_assoc PF09335.11 CCF52207.1 - 0.043 14.3 0.1 0.052 14.0 0.1 1.2 1 0 0 1 1 1 0 SNARE associated Golgi protein PS_Dcarbxylase PF02666.15 CCF52208.1 - 4.8e-75 251.5 0.0 1.1e-56 191.6 0.0 2.1 1 1 1 2 2 2 2 Phosphatidylserine decarboxylase NADH_oxidored PF08040.11 CCF52208.1 - 0.018 14.7 0.1 0.039 13.6 0.1 1.5 1 0 0 1 1 1 0 MNLL subunit Nnf1 PF03980.14 CCF52209.1 - 2.3e-13 50.5 9.3 2.3e-13 50.5 9.3 2.8 3 1 0 3 3 3 1 Nnf1 DUF2968 PF11180.8 CCF52209.1 - 0.0013 18.4 6.4 0.0013 18.4 6.4 2.5 1 1 1 2 2 2 1 Protein of unknown function (DUF2968) Filament PF00038.21 CCF52209.1 - 0.0029 17.2 11.0 0.012 15.2 10.7 2.1 1 1 0 1 1 1 1 Intermediate filament protein YdaT_toxin PF06254.11 CCF52209.1 - 0.052 14.1 3.0 1.9 9.1 0.2 3.0 2 1 1 3 3 3 0 Putative bacterial toxin ydaT HAUS6_N PF14661.6 CCF52209.1 - 0.58 9.7 13.1 0.14 11.8 0.2 3.2 1 1 3 4 4 4 0 HAUS augmin-like complex subunit 6 N-terminus Ank_2 PF12796.7 CCF52210.1 - 4.8e-47 158.5 0.3 3.2e-19 69.3 0.0 3.1 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_5 PF13857.6 CCF52210.1 - 3e-33 113.4 1.8 1.3e-10 41.3 0.0 5.0 2 1 3 5 5 5 4 Ankyrin repeats (many copies) Ank_4 PF13637.6 CCF52210.1 - 3.1e-29 101.0 3.1 8.7e-15 54.9 0.2 3.7 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 CCF52210.1 - 2.5e-21 73.5 0.2 0.00021 21.5 0.0 4.8 4 0 0 4 4 4 4 Ankyrin repeat Ank PF00023.30 CCF52210.1 - 2e-20 72.3 0.6 1.3e-06 28.5 0.1 4.7 4 0 0 4 4 4 3 Ankyrin repeat FYVE PF01363.21 CCF52210.1 - 7.7e-20 70.8 6.4 7.7e-20 70.8 6.4 3.1 3 0 0 3 3 3 1 FYVE zinc finger zf-RING_2 PF13639.6 CCF52210.1 - 7e-08 32.7 4.6 7e-08 32.7 4.6 3.5 3 0 0 3 3 3 1 Ring finger domain zf-C3HC4_2 PF13923.6 CCF52210.1 - 7.2e-05 22.5 2.9 7.2e-05 22.5 2.9 3.2 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 CCF52210.1 - 0.00054 19.7 5.5 0.00054 19.7 5.5 1.9 2 0 0 2 2 2 1 RING-like zinc finger zf-RING_UBOX PF13445.6 CCF52210.1 - 0.0022 17.9 4.4 0.0022 17.9 4.4 2.7 3 0 0 3 3 2 1 RING-type zinc-finger zf-rbx1 PF12678.7 CCF52210.1 - 0.013 15.7 2.8 0.013 15.7 2.8 2.2 2 0 0 2 2 1 0 RING-H2 zinc finger domain RINGv PF12906.7 CCF52210.1 - 0.19 11.9 3.8 0.67 10.1 3.8 2.0 1 0 0 1 1 1 0 RING-variant domain FANCL_C PF11793.8 CCF52210.1 - 0.33 11.2 5.7 0.19 12.0 2.5 2.2 2 0 0 2 2 2 0 FANCL C-terminal domain FYVE_2 PF02318.16 CCF52210.1 - 6.5 7.0 8.1 0.5 10.6 2.1 2.2 2 0 0 2 2 2 0 FYVE-type zinc finger Hist_deacetyl PF00850.19 CCF52212.1 - 6.7e-85 285.3 0.0 1.1e-84 284.6 0.0 1.3 1 0 0 1 1 1 1 Histone deacetylase domain Arb2 PF09757.9 CCF52212.1 - 9.8e-30 103.5 0.0 1.4e-29 103.1 0.0 1.2 1 0 0 1 1 1 1 Arb2 domain PTPA PF03095.15 CCF52213.1 - 6.5e-118 393.6 0.0 7.8e-118 393.3 0.0 1.0 1 0 0 1 1 1 1 Phosphotyrosyl phosphate activator (PTPA) protein RGS PF00615.19 CCF52214.1 - 8.5e-38 129.3 0.0 3.7e-37 127.2 0.0 2.2 1 0 0 1 1 1 1 Regulator of G protein signaling domain DEP PF00610.21 CCF52214.1 - 1.8e-09 37.5 0.1 0.039 14.0 0.0 3.6 3 0 0 3 3 3 3 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) HTH_45 PF14947.6 CCF52214.1 - 0.011 15.8 0.1 2.2 8.3 0.0 3.0 3 0 0 3 3 3 0 Winged helix-turn-helix 3HCDH_N PF02737.18 CCF52215.1 - 1.6e-44 151.9 3.0 1.4e-43 148.9 3.0 2.0 1 1 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.22 CCF52215.1 - 3.1e-34 117.5 0.0 6.1e-34 116.5 0.0 1.5 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain DAO PF01266.24 CCF52215.1 - 0.023 14.3 0.2 0.037 13.6 0.2 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase Arf PF00025.21 CCF52216.1 - 2.7e-27 95.3 0.1 2.8e-21 75.8 0.0 3.1 3 0 0 3 3 3 3 ADP-ribosylation factor family Roc PF08477.13 CCF52216.1 - 9.1e-11 42.0 0.0 9.6e-10 38.7 0.0 2.2 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 CCF52216.1 - 2.7e-09 36.7 0.0 1.1e-06 28.1 0.0 2.1 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.22 CCF52216.1 - 3.8e-07 29.8 0.0 3e-05 23.7 0.0 2.3 2 0 0 2 2 2 1 Ras family MMR_HSR1 PF01926.23 CCF52216.1 - 9.1e-05 22.5 0.0 0.00014 22.0 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 CCF52216.1 - 0.00032 20.1 0.0 0.00042 19.7 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_16 PF13191.6 CCF52216.1 - 0.00038 20.9 0.0 0.001 19.5 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain RsgA_GTPase PF03193.16 CCF52216.1 - 0.0032 17.4 0.0 0.17 11.8 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase AAA_22 PF13401.6 CCF52216.1 - 0.0038 17.5 0.0 0.014 15.7 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.6 CCF52216.1 - 0.075 12.8 0.0 0.19 11.5 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_33 PF13671.6 CCF52216.1 - 0.084 13.0 0.0 0.16 12.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain SRPRB PF09439.10 CCF52216.1 - 0.13 11.7 0.0 1.5 8.2 0.0 2.0 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit MCM PF00493.23 CCF52216.1 - 0.18 10.8 0.0 0.27 10.3 0.0 1.2 1 0 0 1 1 1 0 MCM P-loop domain DUF1640 PF07798.11 CCF52217.1 - 5.1e-59 199.2 5.3 6e-59 199.0 5.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1640) T2SSK PF03934.13 CCF52217.1 - 0.011 15.1 0.3 0.018 14.4 0.3 1.3 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein K DotU PF09850.9 CCF52217.1 - 0.043 13.5 1.2 0.71 9.6 0.0 2.5 2 1 0 2 2 2 0 Type VI secretion system protein DotU Phage_GP20 PF06810.11 CCF52217.1 - 0.043 13.6 2.5 0.061 13.1 2.5 1.2 1 0 0 1 1 1 0 Phage minor structural protein GP20 HALZ PF02183.18 CCF52217.1 - 0.39 11.0 5.1 1.6 9.0 5.1 2.0 1 1 0 1 1 1 0 Homeobox associated leucine zipper FIST PF08495.10 CCF52218.1 - 0.00021 21.3 0.0 0.00088 19.3 0.0 1.8 1 1 0 2 2 2 1 FIST N domain RAP80_UIM PF18282.1 CCF52218.1 - 0.02 14.7 0.9 0.041 13.6 0.9 1.5 1 0 0 1 1 1 0 RAP80 N-terminal ubiquitin interaction motif Erv26 PF04148.13 CCF52218.1 - 0.061 13.1 0.0 0.11 12.3 0.0 1.3 1 0 0 1 1 1 0 Transmembrane adaptor Erv26 UPF0172 PF03665.13 CCF52219.1 - 2.7e-50 171.1 0.1 3.1e-50 170.9 0.1 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0172) JAB PF01398.21 CCF52219.1 - 0.0042 17.1 0.0 0.0066 16.4 0.0 1.4 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease RraA-like PF03737.15 CCF52220.1 - 2.4e-31 108.9 0.0 3.3e-31 108.5 0.0 1.1 1 0 0 1 1 1 1 Aldolase/RraA SAP PF02037.27 CCF52221.1 - 1.7e-09 37.2 0.6 2.9e-09 36.5 0.6 1.4 1 0 0 1 1 1 1 SAP domain PPP4R2 PF09184.11 CCF52221.1 - 5.4 6.5 8.6 9.6 5.7 8.6 1.3 1 0 0 1 1 1 0 PPP4R2 Lipase_3 PF01764.25 CCF52222.1 - 7.7e-25 87.4 0.0 1.1e-24 87.0 0.0 1.2 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_6 PF12697.7 CCF52222.1 - 0.0041 17.7 0.9 0.0063 17.1 0.2 1.6 1 1 1 2 2 2 1 Alpha/beta hydrolase family Cutinase PF01083.22 CCF52222.1 - 0.0054 16.7 0.3 0.14 12.1 0.0 2.2 2 0 0 2 2 2 1 Cutinase Abhydrolase_1 PF00561.20 CCF52222.1 - 0.076 12.6 0.0 0.19 11.3 0.0 1.6 1 1 0 1 1 1 0 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CCF52222.1 - 0.078 12.2 0.0 0.14 11.4 0.0 1.4 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Abhydrolase_3 PF07859.13 CCF52225.1 - 6.1e-12 45.9 0.0 2.9e-11 43.6 0.0 1.8 1 1 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CCF52225.1 - 2.8e-06 28.1 0.1 3.9e-06 27.6 0.1 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 CCF52225.1 - 5e-05 22.9 0.1 0.0026 17.3 0.0 2.1 2 0 0 2 2 2 1 Prolyl oligopeptidase family COesterase PF00135.28 CCF52225.1 - 0.00082 18.4 0.0 0.0016 17.4 0.0 1.4 1 0 0 1 1 1 1 Carboxylesterase family Hydrolase_4 PF12146.8 CCF52225.1 - 0.056 12.7 0.0 0.52 9.5 0.0 2.1 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Abhydrolase_2 PF02230.16 CCF52225.1 - 0.19 11.5 0.0 7.9 6.2 0.0 2.2 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase DUF2920 PF11144.8 CCF52225.1 - 0.26 10.4 0.4 12 4.9 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2920) MR_MLE_C PF13378.6 CCF52226.1 - 7.5e-43 146.6 0.2 5e-42 143.9 0.2 2.0 1 1 0 1 1 1 1 Enolase C-terminal domain-like MR_MLE_N PF02746.16 CCF52226.1 - 0.00029 21.0 0.0 0.0006 20.0 0.0 1.4 1 0 0 1 1 1 1 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain Lipase_3 PF01764.25 CCF52227.1 - 1.3e-16 60.7 0.0 2.5e-16 59.8 0.0 1.4 1 0 0 1 1 1 1 Lipase (class 3) Nop14 PF04147.12 CCF52227.1 - 0.36 9.0 9.7 0.56 8.4 9.7 1.2 1 0 0 1 1 1 0 Nop14-like family DUF4632 PF15451.6 CCF52227.1 - 0.66 10.1 4.8 33 4.6 0.0 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4632) NOA36 PF06524.12 CCF52227.1 - 6.5 6.0 11.9 12 5.2 11.9 1.3 1 0 0 1 1 1 0 NOA36 protein CENP-B_dimeris PF09026.10 CCF52228.1 - 0.032 14.6 0.5 0.032 14.6 0.5 4.1 3 1 1 4 4 4 0 Centromere protein B dimerisation domain RXT2_N PF08595.11 CCF52228.1 - 1.9 8.5 12.1 4.9 7.2 0.1 3.9 3 1 0 3 3 3 0 RXT2-like, N-terminal GST_N_3 PF13417.6 CCF52229.1 - 5.3e-05 23.5 0.0 8.8e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 CCF52229.1 - 0.0021 18.3 0.0 0.0037 17.5 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 CCF52229.1 - 0.023 14.9 0.0 0.053 13.7 0.0 1.6 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 CCF52229.1 - 0.13 12.3 0.0 0.2 11.7 0.0 1.5 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain G_glu_transpept PF01019.21 CCF52231.1 - 1.8e-138 462.5 1.5 4.4e-137 457.9 1.5 2.0 1 1 0 1 1 1 1 Gamma-glutamyltranspeptidase PAC2 PF09754.9 CCF52232.1 - 0.021 14.8 0.0 0.052 13.5 0.0 1.8 1 1 0 1 1 1 0 PAC2 family Pkinase PF00069.25 CCF52233.1 - 4.9e-72 242.5 0.0 8.1e-72 241.7 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF52233.1 - 2.9e-32 112.0 0.0 4.7e-31 108.0 0.0 2.3 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCF52233.1 - 4.2e-05 23.0 3.2 1.4 8.2 0.1 3.4 3 1 0 3 3 3 3 Kinase-like RIO1 PF01163.22 CCF52233.1 - 0.0001 22.0 1.9 0.00018 21.1 1.9 1.4 1 0 0 1 1 1 1 RIO1 family APH PF01636.23 CCF52233.1 - 0.012 15.5 6.6 0.34 10.8 0.0 2.9 2 1 1 3 3 3 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 CCF52233.1 - 0.2 10.4 8.4 0.018 13.8 1.5 2.3 2 1 0 2 2 2 0 Fungal protein kinase G10 PF01125.17 CCF52234.1 - 9.5e-67 223.3 3.8 1.1e-66 223.1 3.8 1.0 1 0 0 1 1 1 1 G10 protein DEAD PF00270.29 CCF52235.1 - 7.9e-26 90.9 0.0 1.3e-25 90.2 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase DUF1998 PF09369.10 CCF52235.1 - 3.5e-19 69.3 0.4 9.9e-19 67.9 0.4 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF1998) Helicase_C PF00271.31 CCF52235.1 - 1.4e-14 54.3 0.1 8.5e-14 51.8 0.1 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CCF52235.1 - 4.2e-07 30.1 0.0 7.5e-07 29.3 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CDT1 PF08839.11 CCF52235.1 - 1.8e-06 28.4 0.0 4.3e-06 27.1 0.0 1.6 1 0 0 1 1 1 1 DNA replication factor CDT1 like T2SSE PF00437.20 CCF52235.1 - 0.055 12.5 0.0 0.12 11.4 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein Methyltransf_31 PF13847.6 CCF52236.1 - 1.1e-16 61.0 0.0 1.4e-16 60.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF52236.1 - 9.1e-15 55.2 0.0 1.5e-14 54.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF52236.1 - 2.5e-14 53.7 0.0 4.7e-14 52.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCF52236.1 - 2.9e-12 46.7 0.0 4.6e-12 46.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF52236.1 - 7.4e-12 45.9 0.0 1.1e-11 45.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CCF52236.1 - 6.6e-08 32.2 0.0 5.2e-07 29.2 0.0 1.9 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family PCMT PF01135.19 CCF52236.1 - 8.4e-08 32.2 0.0 1.2e-07 31.7 0.0 1.1 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MTS PF05175.14 CCF52236.1 - 0.00015 21.4 0.0 0.00022 20.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltr_RsmB-F PF01189.17 CCF52236.1 - 0.051 13.2 0.0 0.072 12.7 0.0 1.3 1 0 0 1 1 1 0 16S rRNA methyltransferase RsmB/F CMAS PF02353.20 CCF52236.1 - 0.078 12.3 0.0 0.098 11.9 0.0 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase PrmA PF06325.13 CCF52236.1 - 0.13 11.6 0.0 0.17 11.2 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_32 PF13679.6 CCF52236.1 - 0.13 12.2 0.0 0.19 11.7 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_9 PF08003.11 CCF52236.1 - 0.16 10.9 0.0 0.21 10.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) Pyridoxal_deC PF00282.19 CCF52237.1 - 1.7e-66 224.5 0.0 2.2e-66 224.1 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.19 CCF52237.1 - 0.0064 15.5 0.0 0.011 14.7 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 CCF52237.1 - 0.056 12.7 0.0 0.17 11.2 0.0 1.7 1 1 0 1 1 1 0 Beta-eliminating lyase DUF155 PF02582.14 CCF52238.1 - 5.3e-50 169.9 0.0 8.5e-50 169.3 0.0 1.3 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 Rhomboid PF01694.22 CCF52239.1 - 2.3e-24 86.1 8.4 2.3e-24 86.1 8.4 1.4 2 0 0 2 2 2 1 Rhomboid family PIG-P PF08510.12 CCF52239.1 - 0.12 12.2 2.4 0.32 10.9 2.4 1.7 1 0 0 1 1 1 0 PIG-P Thioredoxin PF00085.20 CCF52240.1 - 0.00072 19.5 0.0 0.0013 18.7 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin DUF4698 PF15769.5 CCF52240.1 - 0.025 13.6 2.6 0.031 13.4 2.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4698) AIM3 PF17096.5 CCF52240.1 - 0.13 13.2 0.1 0.22 12.5 0.1 1.4 1 0 0 1 1 1 0 Altered inheritance of mitochondria protein 3 Inhibitor_I9 PF05922.16 CCF52241.1 - 3.4e-05 24.4 0.1 8.3e-05 23.2 0.1 1.7 1 1 0 1 1 1 1 Peptidase inhibitor I9 UPF0029 PF01205.19 CCF52242.1 - 2.7e-32 111.2 0.0 4.5e-32 110.5 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized protein family UPF0029 RWD PF05773.22 CCF52242.1 - 5e-07 30.0 0.1 5.6e-06 26.6 0.1 2.3 1 1 0 1 1 1 1 RWD domain F-box-like PF12937.7 CCF52243.1 - 0.02 14.8 0.5 0.051 13.5 0.5 1.8 1 0 0 1 1 1 0 F-box-like Peptidase_M50B PF13398.6 CCF52244.1 - 8.7e-61 205.1 16.7 1.1e-60 204.7 16.7 1.1 1 0 0 1 1 1 1 Peptidase M50B-like His_Phos_1 PF00300.22 CCF52245.1 - 3.1e-34 118.4 0.8 1.3e-33 116.3 0.8 2.0 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) NECFESHC PF16621.5 CCF52249.1 - 0.22 11.5 7.0 6 6.9 0.1 3.8 4 0 0 4 4 4 0 SH3 terminal domain of 2nd SH3 on Neutrophil cytosol factor 1 Plasmo_rep PF12135.8 CCF52251.1 - 0.11 12.1 0.0 10 5.8 0.0 2.4 2 0 0 2 2 2 0 Plasmodium repeat family Lactonase PF10282.9 CCF52252.1 - 2.7e-18 66.4 0.0 1.5e-15 57.3 0.0 2.4 2 0 0 2 2 2 2 Lactonase, 7-bladed beta-propeller SGL PF08450.12 CCF52252.1 - 0.0079 15.8 0.0 0.016 14.8 0.0 1.5 1 0 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region FAD_binding_4 PF01565.23 CCF52253.1 - 1.9e-21 76.3 3.1 3.4e-21 75.4 3.1 1.4 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 CCF52253.1 - 0.0011 19.0 0.0 0.0027 17.8 0.0 1.6 1 0 0 1 1 1 1 Berberine and berberine like Acetyltransf_7 PF13508.7 CCF52254.1 - 1.7e-06 28.4 0.0 3.2e-06 27.5 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 CCF52254.1 - 4e-06 26.8 0.0 1e-05 25.4 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CCF52254.1 - 5.5e-06 26.6 0.0 9.6e-06 25.8 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family UPF0020 PF01170.18 CCF52255.1 - 1.7e-07 31.2 0.2 2.3e-06 27.4 0.2 2.3 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 N6_N4_Mtase PF01555.18 CCF52255.1 - 0.14 11.9 0.0 1.6 8.4 0.0 2.2 2 0 0 2 2 2 0 DNA methylase AA_permease_2 PF13520.6 CCF52256.1 - 4e-69 233.5 54.1 4.9e-69 233.2 54.1 1.0 1 0 0 1 1 1 1 Amino acid permease FMO-like PF00743.19 CCF52257.1 - 9.5e-18 63.9 0.1 5.7e-17 61.3 0.1 2.1 1 1 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.14 CCF52257.1 - 1.8e-16 60.2 0.1 3.4e-13 49.5 0.2 2.4 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CCF52257.1 - 2.8e-14 53.1 0.1 7.8e-11 41.8 0.1 3.5 2 1 1 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CCF52257.1 - 5.8e-11 42.6 0.4 1.3e-07 31.6 0.0 3.0 3 0 0 3 3 3 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CCF52257.1 - 7.7e-10 38.9 1.8 7.1e-08 32.6 0.0 3.0 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 CCF52257.1 - 6.8e-07 29.8 1.4 0.012 16.1 0.5 2.6 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 CCF52257.1 - 8e-07 28.6 1.4 0.0079 15.5 0.1 2.2 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain K_oxygenase PF13434.6 CCF52257.1 - 2.9e-06 26.6 0.1 0.00067 18.9 0.0 2.9 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 CCF52257.1 - 2.1e-05 24.6 6.9 0.00023 21.2 0.3 3.7 4 0 0 4 4 4 1 FAD-NAD(P)-binding Amino_oxidase PF01593.24 CCF52257.1 - 4.4e-05 23.0 0.1 0.0019 17.5 0.0 2.7 2 1 1 3 3 3 1 Flavin containing amine oxidoreductase Shikimate_DH PF01488.20 CCF52257.1 - 0.00023 21.2 0.3 0.47 10.5 0.1 2.7 3 0 0 3 3 3 2 Shikimate / quinate 5-dehydrogenase NAD_binding_7 PF13241.6 CCF52257.1 - 0.00035 21.0 0.0 0.46 10.9 0.0 2.6 3 0 0 3 3 2 2 Putative NAD(P)-binding FAD_binding_3 PF01494.19 CCF52257.1 - 0.00094 18.5 2.5 0.092 12.0 0.5 2.5 2 0 0 2 2 2 2 FAD binding domain 3HCDH_N PF02737.18 CCF52257.1 - 0.0013 18.7 0.2 0.0027 17.6 0.2 1.6 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain FAD_binding_2 PF00890.24 CCF52257.1 - 0.0057 15.8 0.4 0.0057 15.8 0.4 2.1 2 0 0 2 2 2 1 FAD binding domain HI0933_like PF03486.14 CCF52257.1 - 0.012 14.4 4.5 0.097 11.4 1.0 2.4 2 0 0 2 2 2 0 HI0933-like protein 2-Hacid_dh_C PF02826.19 CCF52257.1 - 0.061 12.7 0.2 9.3 5.6 0.0 2.5 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain FAD_oxidored PF12831.7 CCF52257.1 - 0.067 12.5 0.2 3 7.1 0.0 2.1 2 0 0 2 2 2 0 FAD dependent oxidoreductase GIDA PF01134.22 CCF52257.1 - 0.071 12.2 2.6 1.2 8.1 0.3 2.5 2 0 0 2 2 2 0 Glucose inhibited division protein A Thi4 PF01946.17 CCF52257.1 - 0.089 12.0 1.7 1 8.5 0.3 2.4 2 0 0 2 2 2 0 Thi4 family NAD_binding_2 PF03446.15 CCF52257.1 - 0.12 12.5 0.1 0.24 11.5 0.1 1.4 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase ThiF PF00899.21 CCF52257.1 - 0.15 11.4 0.5 9.7 5.5 0.0 2.3 2 0 0 2 2 2 0 ThiF family ADH_N PF08240.12 CCF52258.1 - 9.7e-26 89.8 3.5 1.9e-25 88.8 3.5 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CCF52258.1 - 4.9e-23 81.5 0.0 7.4e-23 81.0 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 CCF52258.1 - 8.3e-11 41.8 0.0 3.7e-09 36.4 0.0 2.3 1 1 0 1 1 1 1 Glucose dehydrogenase C-terminus ADH_zinc_N_2 PF13602.6 CCF52258.1 - 0.00053 21.0 0.0 0.0014 19.7 0.0 1.7 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Pyr_redox_2 PF07992.14 CCF52258.1 - 0.027 13.7 0.0 0.043 13.0 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase TmoB PF06234.12 CCF52258.1 - 0.043 13.9 0.1 0.15 12.2 0.0 2.0 2 0 0 2 2 2 0 Toluene-4-monooxygenase system protein B (TmoB) DUF1495 PF07381.11 CCF52258.1 - 0.17 11.7 0.0 0.35 10.7 0.0 1.4 1 0 0 1 1 1 0 Winged helix DNA-binding domain (DUF1495) F-box-like PF12937.7 CCF52261.1 - 2.2e-10 40.2 1.5 4.6e-10 39.2 1.5 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 CCF52261.1 - 3.4e-08 33.2 0.7 1.1e-07 31.5 0.5 2.1 2 0 0 2 2 2 1 F-box domain TPR_9 PF13371.6 CCF52261.1 - 0.00041 20.4 0.1 0.0012 19.0 0.1 1.8 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_2 PF07719.17 CCF52261.1 - 0.00049 20.0 3.2 0.038 14.1 0.3 3.3 3 0 0 3 3 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 CCF52261.1 - 0.0033 17.5 0.1 0.29 11.5 0.0 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 CCF52261.1 - 0.0043 16.8 0.3 0.12 12.3 0.1 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_15 PF13429.6 CCF52261.1 - 0.0069 15.6 0.7 0.016 14.4 0.1 1.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.6 CCF52261.1 - 0.032 14.9 9.3 0.075 13.7 2.5 3.1 3 0 0 3 3 2 0 Tetratricopeptide repeat TPR_19 PF14559.6 CCF52261.1 - 0.037 14.5 1.3 0.13 12.8 1.3 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_11 PF13414.6 CCF52261.1 - 0.077 12.7 0.1 0.33 10.7 0.0 2.0 2 0 0 2 2 2 0 TPR repeat F-box_4 PF15966.5 CCF52261.1 - 0.098 12.5 0.0 0.25 11.2 0.0 1.7 1 0 0 1 1 1 0 F-box PaaX_C PF08223.11 CCF52261.1 - 0.11 12.7 1.9 0.61 10.4 0.1 3.1 4 0 0 4 4 4 0 PaaX-like protein C-terminal domain TPR_12 PF13424.6 CCF52261.1 - 0.13 12.5 4.4 0.29 11.5 2.2 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 CCF52261.1 - 0.65 11.0 8.6 1 10.4 0.5 4.5 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.6 CCF52262.1 - 0.0011 19.5 0.0 0.0017 18.8 0.0 1.4 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_2 PF07719.17 CCF52262.1 - 0.014 15.5 0.0 0.28 11.4 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_9 PF13371.6 CCF52262.1 - 0.031 14.4 0.0 0.065 13.4 0.0 1.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_11 PF13414.6 CCF52262.1 - 0.049 13.3 0.0 1.9 8.3 0.0 2.3 1 1 1 2 2 2 0 TPR repeat ABC_tran PF00005.27 CCF52263.1 - 2.4e-43 148.0 0.7 1.4e-22 80.7 0.0 4.1 3 1 0 3 3 3 2 ABC transporter AAA_21 PF13304.6 CCF52263.1 - 6e-13 49.3 4.9 0.0025 17.7 0.0 5.1 5 0 0 5 5 5 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CCF52263.1 - 4e-11 42.8 0.0 0.00043 19.8 0.0 3.7 2 2 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CCF52263.1 - 2.3e-08 33.7 0.5 0.0065 16.2 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_30 PF13604.6 CCF52263.1 - 1.5e-07 31.4 3.1 0.00025 20.8 0.1 3.7 4 0 0 4 4 3 2 AAA domain ABC_tran_Xtn PF12848.7 CCF52263.1 - 3.7e-07 30.1 5.2 1e-06 28.7 5.2 1.8 1 0 0 1 1 1 1 ABC transporter MMR_HSR1 PF01926.23 CCF52263.1 - 1.8e-06 28.0 0.2 0.012 15.7 0.1 3.1 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_23 PF13476.6 CCF52263.1 - 5.3e-06 27.1 9.7 0.0019 18.7 0.0 3.5 4 0 0 4 4 3 2 AAA domain RsgA_GTPase PF03193.16 CCF52263.1 - 8.5e-05 22.5 0.4 0.49 10.3 0.1 3.3 3 0 0 3 3 3 2 RsgA GTPase AAA PF00004.29 CCF52263.1 - 0.00011 22.7 0.4 0.49 10.8 0.2 3.5 3 1 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) NB-ARC PF00931.22 CCF52263.1 - 0.00026 20.3 0.0 0.2 10.8 0.0 2.6 2 0 0 2 2 2 2 NB-ARC domain MeaB PF03308.16 CCF52263.1 - 0.0003 19.9 2.2 0.84 8.6 0.1 3.5 3 0 0 3 3 3 2 Methylmalonyl Co-A mutase-associated GTPase MeaB NACHT PF05729.12 CCF52263.1 - 0.00042 20.3 0.0 0.45 10.4 0.0 2.6 2 0 0 2 2 2 1 NACHT domain AAA_15 PF13175.6 CCF52263.1 - 0.00043 20.1 0.7 0.57 9.8 0.0 3.1 3 0 0 3 3 3 1 AAA ATPase domain AAA_16 PF13191.6 CCF52263.1 - 0.00063 20.2 1.4 1.3 9.4 0.4 2.9 2 0 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.6 CCF52263.1 - 0.00074 19.8 0.4 1.6 9.0 0.0 3.2 3 1 0 3 3 2 1 AAA domain RNA_helicase PF00910.22 CCF52263.1 - 0.002 18.5 0.0 1.2 9.5 0.0 2.7 2 0 0 2 2 2 1 RNA helicase AAA_14 PF13173.6 CCF52263.1 - 0.0021 18.1 0.3 5.1 7.1 0.0 3.5 4 0 0 4 4 2 0 AAA domain AAA_27 PF13514.6 CCF52263.1 - 0.0024 17.5 0.1 0.86 9.2 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_7 PF12775.7 CCF52263.1 - 0.0043 16.6 0.1 2.8 7.4 0.1 2.3 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_5 PF07728.14 CCF52263.1 - 0.0045 17.0 0.4 9.9 6.2 0.0 3.7 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) ABC_ATPase PF09818.9 CCF52263.1 - 0.009 14.8 1.0 0.43 9.3 0.0 2.6 2 0 0 2 2 2 1 Predicted ATPase of the ABC class AAA_24 PF13479.6 CCF52263.1 - 0.01 15.5 0.2 5.1 6.8 0.2 2.7 2 0 0 2 2 2 0 AAA domain MobB PF03205.14 CCF52263.1 - 0.013 15.4 0.5 0.91 9.4 0.1 2.6 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B NTPase_1 PF03266.15 CCF52263.1 - 0.015 15.2 3.2 1.1 9.2 0.1 3.2 3 0 0 3 3 3 0 NTPase IstB_IS21 PF01695.17 CCF52263.1 - 0.017 14.9 2.5 1.2 8.8 0.0 3.2 3 0 0 3 3 3 0 IstB-like ATP binding protein MukB PF04310.12 CCF52263.1 - 0.018 14.9 0.8 4.8 6.9 0.1 2.6 2 1 0 2 2 2 0 MukB N-terminal AAA_25 PF13481.6 CCF52263.1 - 0.022 14.4 0.5 5.3 6.6 0.0 3.5 4 0 0 4 4 3 0 AAA domain Dynamin_N PF00350.23 CCF52263.1 - 0.022 14.8 0.0 1.2 9.2 0.0 2.6 2 0 0 2 2 2 0 Dynamin family AAA_28 PF13521.6 CCF52263.1 - 0.028 14.7 3.0 7.8 6.7 0.1 3.4 3 0 0 3 3 3 0 AAA domain Roc PF08477.13 CCF52263.1 - 0.053 13.7 0.1 3.5 7.9 0.0 2.5 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase SbcCD_C PF13558.6 CCF52263.1 - 0.055 13.7 0.0 0.43 10.9 0.0 2.6 2 0 0 2 2 2 0 Putative exonuclease SbcCD, C subunit ATPase_2 PF01637.18 CCF52263.1 - 0.055 13.4 1.7 2.4 8.0 0.0 3.1 3 0 0 3 3 3 0 ATPase domain predominantly from Archaea AAA_33 PF13671.6 CCF52263.1 - 0.095 12.9 3.2 6.3 7.0 0.1 3.3 2 1 0 2 2 2 0 AAA domain SRP54 PF00448.22 CCF52263.1 - 0.13 11.8 0.7 16 5.0 0.0 2.4 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain Mucin PF01456.17 CCF52263.1 - 0.15 12.0 11.8 0.29 11.1 11.8 1.4 1 0 0 1 1 1 0 Mucin-like glycoprotein cobW PF02492.19 CCF52263.1 - 1.6 8.3 4.8 2.6 7.6 0.3 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain FAM25 PF15825.5 CCF52263.1 - 3.4 8.1 6.2 0.96 9.8 2.1 2.2 2 0 0 2 2 1 0 FAM25 family Ribosomal_60s PF00428.19 CCF52263.1 - 5.7 7.6 11.9 4.3 8.0 1.1 3.5 3 0 0 3 3 3 0 60s Acidic ribosomal protein DUF87 PF01935.17 CCF52263.1 - 8.7 6.4 9.7 1.8 8.6 0.2 3.0 3 0 0 3 3 2 0 Helicase HerA, central domain 4HBT PF03061.22 CCF52264.1 - 5.3e-16 58.7 4.6 1.2e-08 35.2 0.2 2.6 2 0 0 2 2 2 2 Thioesterase superfamily AA_permease_2 PF13520.6 CCF52265.1 - 1.1e-58 199.1 56.2 1.4e-58 198.7 56.2 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 CCF52265.1 - 8e-32 110.4 48.7 1.1e-31 110.0 48.7 1.1 1 0 0 1 1 1 1 Amino acid permease MMgT PF10270.9 CCF52266.1 - 1.4e-17 63.8 0.1 1.7e-17 63.6 0.1 1.1 1 0 0 1 1 1 1 Membrane magnesium transporter Sedlin_N PF04628.13 CCF52267.1 - 2e-20 73.2 0.0 3.4e-19 69.3 0.0 1.9 2 0 0 2 2 2 1 Sedlin, N-terminal conserved region Peptidase_M20 PF01546.28 CCF52268.1 - 6e-36 124.1 0.0 7.5e-36 123.8 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 CCF52268.1 - 4.7e-11 42.6 0.0 1.1e-10 41.3 0.0 1.7 1 1 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 CCF52268.1 - 0.055 13.2 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 Peptidase family M28 Aa_trans PF01490.18 CCF52269.1 - 3.4e-64 217.1 8.7 4.1e-64 216.8 8.7 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 CCF52269.1 - 2.4e-05 23.6 6.6 2.4e-05 23.6 6.6 1.7 2 0 0 2 2 2 1 Tryptophan/tyrosine permease family DUF373 PF04123.13 CCF52269.1 - 8.5 5.7 7.0 4.5 6.6 0.1 2.8 2 1 0 3 3 3 0 Domain of unknown function (DUF373) zf-RING_UBOX PF13445.6 CCF52270.1 - 9.7e-09 35.1 3.8 9.7e-09 35.1 3.8 2.6 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 CCF52270.1 - 8.7e-08 31.9 4.9 8.7e-08 31.9 4.9 4.4 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-Nse PF11789.8 CCF52270.1 - 3e-07 30.1 2.4 1.3e-05 24.9 3.2 2.5 2 1 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit zf-TRAF PF02176.18 CCF52270.1 - 3.6e-07 30.8 32.4 1.1e-06 29.2 3.6 5.1 3 1 1 5 5 5 2 TRAF-type zinc finger zf-RING_5 PF14634.6 CCF52270.1 - 4.4e-07 29.7 5.6 4.4e-07 29.7 5.6 3.4 2 1 1 3 3 2 1 zinc-RING finger domain zf-RING_2 PF13639.6 CCF52270.1 - 1.2e-06 28.8 6.5 1.2e-06 28.8 6.5 4.7 2 1 2 4 4 2 1 Ring finger domain zf-C3HC4 PF00097.25 CCF52270.1 - 8.1e-06 25.6 6.3 8.1e-06 25.6 6.3 3.9 4 1 0 4 4 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 CCF52270.1 - 0.0021 18.2 6.9 0.0021 18.2 6.9 2.8 2 1 0 2 2 1 1 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.6 CCF52270.1 - 0.0051 16.7 5.7 0.0051 16.7 5.7 4.0 2 2 1 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.6 CCF52270.1 - 0.049 13.5 2.8 0.13 12.2 0.8 2.5 2 0 0 2 2 2 0 zf-RING of BARD1-type protein Leu_zip PF15294.6 CCF52270.1 - 0.084 12.4 0.0 0.17 11.4 0.0 1.4 1 0 0 1 1 1 0 Leucine zipper zf-RING_11 PF17123.5 CCF52270.1 - 0.52 10.1 7.7 1.9 8.3 6.9 2.5 2 0 0 2 2 2 0 RING-like zinc finger zf-ACC PF17848.1 CCF52270.1 - 0.61 10.2 10.5 2.3 8.4 0.0 3.3 3 0 0 3 3 3 0 Acetyl-coA carboxylase zinc finger domain Sina PF03145.16 CCF52270.1 - 4.5 7.2 22.6 4.1 7.3 0.6 3.3 1 1 1 3 3 3 0 Seven in absentia protein family C2 PF00168.30 CCF52271.1 - 5.2e-22 78.1 0.0 1.7e-13 50.7 0.0 2.5 2 0 0 2 2 2 2 C2 domain MMM1 PF10296.9 CCF52271.1 - 0.0078 15.3 1.9 0.0081 15.3 0.0 1.9 2 1 0 2 2 2 1 Maintenance of mitochondrial morphology protein 1 Acetyltransf_3 PF13302.7 CCF52272.1 - 2.3e-16 60.7 0.0 3.4e-16 60.2 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CCF52272.1 - 0.022 15.0 0.0 0.032 14.5 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family AstA PF04958.12 CCF52272.1 - 0.11 11.0 0.0 0.16 10.5 0.0 1.1 1 0 0 1 1 1 0 Arginine N-succinyltransferase beta subunit TipE PF16972.5 CCF52273.1 - 0.056 12.6 0.0 0.086 12.0 0.0 1.2 1 0 0 1 1 1 0 Na+ channel auxiliary subunit TipE Pyr_redox_2 PF07992.14 CCF52274.1 - 1.8e-49 168.6 0.0 2.3e-49 168.2 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CCF52274.1 - 2e-11 44.3 0.0 2.5e-10 40.8 0.0 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CCF52274.1 - 0.0041 16.4 0.0 1.2 8.3 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase TPPII_N PF12583.8 CCF52274.1 - 0.059 14.0 0.0 0.25 11.9 0.0 2.0 2 0 0 2 2 2 0 Tripeptidyl peptidase II N terminal NAD_binding_7 PF13241.6 CCF52274.1 - 0.064 13.7 0.1 2.8 8.4 0.0 2.6 2 1 0 2 2 2 0 Putative NAD(P)-binding RCC1 PF00415.18 CCF52275.1 - 8.6e-18 64.7 8.1 0.022 15.4 0.1 7.4 6 2 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 CCF52275.1 - 3.4e-08 33.1 15.0 0.039 13.8 0.1 7.1 7 0 0 7 7 7 4 Regulator of chromosome condensation (RCC1) repeat Pkinase PF00069.25 CCF52278.1 - 2e-38 132.3 0.0 3.8e-22 78.9 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CCF52278.1 - 4.4e-14 52.4 0.0 1.5e-09 37.5 0.0 2.7 3 0 0 3 3 3 2 Protein tyrosine kinase Kinase-like PF14531.6 CCF52278.1 - 0.00012 21.5 0.0 0.42 9.9 0.0 2.1 2 0 0 2 2 2 2 Kinase-like APH PF01636.23 CCF52278.1 - 0.077 12.9 0.0 0.38 10.6 0.0 2.1 2 0 0 2 2 2 0 Phosphotransferase enzyme family MIP PF00230.20 CCF52279.1 - 2e-26 93.1 10.1 2.8e-26 92.6 10.1 1.1 1 0 0 1 1 1 1 Major intrinsic protein SET PF00856.28 CCF52280.1 - 0.00082 19.8 0.0 0.0027 18.1 0.0 1.9 2 0 0 2 2 2 1 SET domain RTA1 PF04479.13 CCF52281.1 - 3.3e-66 222.8 1.8 3.3e-66 222.8 1.8 1.4 2 0 0 2 2 2 1 RTA1 like protein Abhydrolase_9_N PF15420.6 CCF52281.1 - 0.02 14.9 2.9 0.049 13.6 0.5 2.2 1 1 1 2 2 2 0 Alpha/beta-hydrolase family N-terminus Tox-SGS PF15651.6 CCF52281.1 - 0.3 11.3 1.4 6.5 7.1 0.0 2.7 2 1 0 2 2 2 0 Salivary glad secreted protein domain toxin Syndecan PF01034.20 CCF52281.1 - 3.5 7.6 5.2 25 4.9 0.0 3.5 3 0 0 3 3 3 0 Syndecan domain DUF805 PF05656.14 CCF52281.1 - 5.5 7.5 7.1 58 4.2 7.1 2.6 1 1 0 1 1 1 0 Protein of unknown function (DUF805) Epimerase PF01370.21 CCF52283.1 - 7.7e-18 64.8 0.0 2.1e-17 63.4 0.0 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 CCF52283.1 - 1.7e-09 37.1 0.0 5.1e-09 35.5 0.0 1.8 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 CCF52283.1 - 2.6e-09 36.7 0.0 3.5e-08 32.9 0.0 2.1 1 1 0 1 1 1 1 Male sterility protein NAD_binding_10 PF13460.6 CCF52283.1 - 4.5e-07 30.0 0.0 1.6e-06 28.1 0.0 2.0 2 0 0 2 2 2 1 NAD(P)H-binding RmlD_sub_bind PF04321.17 CCF52283.1 - 2.2e-06 27.0 0.0 0.00041 19.5 0.0 2.2 2 0 0 2 2 2 2 RmlD substrate binding domain GDP_Man_Dehyd PF16363.5 CCF52283.1 - 5.2e-06 26.1 0.0 1.9e-05 24.2 0.0 1.8 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase NmrA PF05368.13 CCF52283.1 - 0.013 15.0 0.0 3.3 7.2 0.0 2.7 2 2 1 3 3 3 0 NmrA-like family Na_K-ATPase PF00287.18 CCF52283.1 - 0.057 12.6 0.5 0.098 11.8 0.5 1.3 1 0 0 1 1 1 0 Sodium / potassium ATPase beta chain Hexokinase_2 PF03727.16 CCF52284.1 - 1.8e-83 279.7 0.2 2.4e-83 279.3 0.2 1.1 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 CCF52284.1 - 3.2e-70 236.1 0.0 4.4e-70 235.6 0.0 1.2 1 0 0 1 1 1 1 Hexokinase MLTD_N PF06474.12 CCF52284.1 - 0.41 10.9 1.8 1.3 9.2 1.8 1.9 1 0 0 1 1 1 0 MltD lipid attachment motif His_Phos_2 PF00328.22 CCF52285.1 - 3.9e-29 102.2 0.0 3e-16 59.8 0.0 2.2 2 0 0 2 2 2 2 Histidine phosphatase superfamily (branch 2) eIF_4EBP PF05456.11 CCF52285.1 - 0.05 13.5 0.3 0.12 12.3 0.3 1.6 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) Complex1_LYR_2 PF13233.6 CCF52286.1 - 6.6e-22 78.1 0.2 1.5e-21 76.9 0.2 1.6 1 0 0 1 1 1 1 Complex1_LYR-like Complex1_LYR PF05347.15 CCF52286.1 - 3.7e-15 55.7 0.2 3.9e-14 52.4 0.1 2.3 2 0 0 2 2 2 1 Complex 1 protein (LYR family) DUF543 PF04418.12 CCF52288.1 - 0.17 11.9 0.1 0.28 11.2 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF543) PseudoU_synth_2 PF00849.22 CCF52289.1 - 6.3e-23 81.6 0.0 1.4e-22 80.5 0.0 1.6 1 0 0 1 1 1 1 RNA pseudouridylate synthase UPF0020 PF01170.18 CCF52289.1 - 8e-14 51.8 0.0 2.2e-13 50.3 0.0 1.7 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_31 PF13847.6 CCF52289.1 - 5.2e-06 26.3 0.0 1.1e-05 25.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain AviRa PF11599.8 CCF52289.1 - 6.6e-06 25.8 0.0 0.0088 15.5 0.1 2.4 1 1 1 2 2 2 2 RRNA methyltransferase AviRa Methyltransf_25 PF13649.6 CCF52289.1 - 0.081 13.6 0.0 0.19 12.4 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain Asp PF00026.23 CCF52290.1 - 4.1e-57 194.0 6.1 8.5e-57 193.0 6.1 1.5 1 1 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 CCF52290.1 - 2.5e-10 40.9 2.8 0.00014 22.1 1.5 2.7 1 1 1 2 2 2 2 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 CCF52290.1 - 6.4e-06 26.7 0.9 0.0011 19.5 0.0 3.1 3 0 0 3 3 3 1 Aspartyl protease gag-asp_proteas PF13975.6 CCF52290.1 - 0.0056 17.2 0.1 0.025 15.1 0.0 2.1 2 0 0 2 2 2 1 gag-polyprotein putative aspartyl protease DUF2985 PF11204.8 CCF52292.1 - 5.1e-24 84.2 0.2 9.8e-24 83.3 0.2 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2985) Cofilin_ADF PF00241.20 CCF52293.1 - 7.7e-18 64.5 0.0 5.7e-10 39.0 0.0 2.3 2 0 0 2 2 2 2 Cofilin/tropomyosin-type actin-binding protein adh_short_C2 PF13561.6 CCF52294.1 - 8.8e-43 146.5 0.0 1.2e-42 146.0 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCF52294.1 - 1.6e-40 138.6 0.1 2.9e-40 137.8 0.1 1.4 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CCF52294.1 - 0.00016 21.7 0.1 0.00022 21.2 0.1 1.2 1 0 0 1 1 1 1 KR domain Sacchrp_dh_NADP PF03435.18 CCF52294.1 - 0.05 13.9 0.0 0.12 12.7 0.0 1.6 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain THF_DHG_CYH_C PF02882.19 CCF52294.1 - 0.072 12.4 0.0 0.18 11.1 0.0 1.6 2 0 0 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Shikimate_DH PF01488.20 CCF52294.1 - 0.16 12.1 0.1 0.28 11.2 0.1 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Complex1_LYR PF05347.15 CCF52295.1 - 1.8e-07 31.1 0.0 1.8e-07 31.1 0.0 1.5 2 0 0 2 2 2 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 CCF52295.1 - 0.022 15.5 0.8 0.038 14.7 0.8 1.5 1 1 0 1 1 1 0 Complex1_LYR-like Prefoldin PF02996.17 CCF52296.1 - 1.7e-11 44.0 0.3 1.7e-11 44.0 0.3 1.4 2 0 0 2 2 2 1 Prefoldin subunit FliD_N PF02465.18 CCF52296.1 - 0.12 13.0 0.8 0.45 11.2 0.0 2.1 2 1 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus TRAP_alpha PF03896.16 CCF52297.1 - 0.16 11.2 0.1 0.22 10.7 0.1 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Spore_coat_CotO PF14153.6 CCF52297.1 - 0.6 10.0 5.0 0.85 9.5 5.0 1.2 1 0 0 1 1 1 0 Spore coat protein CotO Herpes_DNAp_acc PF04929.12 CCF52297.1 - 3.8 6.4 5.7 5.3 5.9 5.7 1.1 1 0 0 1 1 1 0 Herpes DNA replication accessory factor DnaJ_CXXCXGXG PF00684.19 CCF52298.1 - 0.0057 17.0 4.5 0.07 13.5 1.3 2.3 2 0 0 2 2 2 2 DnaJ central domain Anti-TRAP PF15777.5 CCF52298.1 - 8 6.5 7.5 49 4.0 0.5 3.3 3 0 0 3 3 3 0 Tryptophan RNA-binding attenuator protein inhibitory protein Pro_isomerase PF00160.21 CCF52299.1 - 5.3e-43 147.0 0.0 6.1e-43 146.8 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Ribonuclease_3 PF00636.26 CCF52301.1 - 4.3e-11 43.4 0.1 2.3e-10 41.0 0.0 2.4 2 0 0 2 2 2 1 Ribonuclease III domain Ribonucleas_3_3 PF14622.6 CCF52301.1 - 0.078 13.1 0.1 0.85 9.8 0.1 2.3 1 1 0 1 1 1 0 Ribonuclease-III-like NAD_binding_2 PF03446.15 CCF52302.1 - 9.4e-30 103.9 0.3 1.4e-29 103.3 0.3 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 CCF52302.1 - 1.8e-28 99.2 0.0 3.2e-28 98.4 0.0 1.5 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase F420_oxidored PF03807.17 CCF52302.1 - 0.11 13.1 0.2 0.33 11.6 0.2 1.8 1 1 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent bZIP_1 PF00170.21 CCF52304.1 - 1.1e-08 35.0 9.7 1.4e-06 28.3 4.6 2.3 1 1 1 2 2 2 2 bZIP transcription factor Hap4_Hap_bind PF10297.9 CCF52304.1 - 6.5e-08 32.4 3.8 1.9e-07 31.0 3.8 1.9 1 0 0 1 1 1 1 Minimal binding motif of Hap4 for binding to Hap2/3/5 CpXC PF14353.6 CCF52304.1 - 0.13 12.3 0.3 0.56 10.3 0.0 2.0 2 0 0 2 2 2 0 CpXC protein RVT_2 PF07727.14 CCF52306.1 - 1.1e-24 87.4 0.0 1.5e-24 86.9 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 CCF52308.1 - 6.3e-06 26.4 0.1 1.5e-05 25.2 0.1 1.6 1 0 0 1 1 1 1 Integrase core domain gag-asp_proteas PF13975.6 CCF52308.1 - 0.13 12.8 0.0 0.37 11.4 0.0 1.8 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease SPT6_acidic PF14632.6 CCF52310.1 - 0.033 14.8 0.4 0.033 14.8 0.4 1.9 2 0 0 2 2 2 0 Acidic N-terminal SPT6 Acetyltransf_3 PF13302.7 CCF52311.1 - 2.5e-09 38.0 0.0 3.3e-09 37.5 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CCF52311.1 - 4.6e-06 26.9 0.0 6.8e-06 26.3 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.10 CCF52311.1 - 0.00025 20.9 0.0 0.00041 20.3 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_8 PF13523.6 CCF52311.1 - 0.0012 18.5 0.0 0.0017 18.1 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CCF52311.1 - 0.021 15.2 0.0 0.043 14.3 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain PanZ PF12568.8 CCF52311.1 - 0.035 13.8 0.2 0.06 13.1 0.2 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain, PanZ Acetyltransf_CG PF14542.6 CCF52311.1 - 0.095 12.8 0.0 0.16 12.1 0.0 1.3 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase Chromate_transp PF02417.15 CCF52313.1 - 1.4e-58 197.5 32.7 6.6e-33 114.1 11.0 2.5 3 0 0 3 3 3 2 Chromate transporter Phage_sheath_1 PF04984.14 CCF52313.1 - 0.086 12.7 0.7 6.2 6.6 0.1 2.4 2 0 0 2 2 2 0 Phage tail sheath protein subtilisin-like domain Deltameth_res PF16020.5 CCF52313.1 - 9.5 6.2 6.1 5.2 7.0 0.7 2.9 2 0 0 2 2 2 0 Deltamethrin resistance CAF-1_p150 PF11600.8 CCF52314.1 - 0.0094 15.7 19.1 0.015 15.0 19.1 1.3 1 0 0 1 1 1 1 Chromatin assembly factor 1 complex p150 subunit, N-terminal Miga PF10265.9 CCF52314.1 - 0.34 9.8 7.8 0.46 9.4 7.8 1.2 1 0 0 1 1 1 0 Mitoguardin TraH PF06122.11 CCF52314.1 - 0.77 9.0 6.4 1.1 8.5 6.4 1.2 1 0 0 1 1 1 0 Conjugative relaxosome accessory transposon protein DUF4407 PF14362.6 CCF52314.1 - 0.8 9.0 5.9 1.2 8.4 5.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Atg14 PF10186.9 CCF52314.1 - 1.3 8.1 13.8 1.8 7.6 13.8 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Phage_Gp23 PF10669.9 CCF52314.1 - 1.4 9.3 10.8 3.5 8.0 10.8 1.6 1 0 0 1 1 1 0 Protein gp23 (Bacteriophage A118) Tho2 PF11262.8 CCF52314.1 - 4.2 6.5 7.9 6.4 5.9 7.9 1.2 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 NARP1 PF12569.8 CCF52314.1 - 6.5 5.5 14.3 9.6 5.0 14.3 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 zf-HIT PF04438.16 CCF52315.1 - 3.5e-05 23.6 10.0 5.5e-05 22.9 10.0 1.3 1 0 0 1 1 1 1 HIT zinc finger NBD_C PF17042.5 CCF52315.1 - 0.7 10.4 5.3 0.96 9.9 5.3 1.2 1 0 0 1 1 1 0 Nucleotide-binding C-terminal domain zf-MYND PF01753.18 CCF52315.1 - 3.5 7.8 10.9 6.4 7.0 10.9 1.5 1 0 0 1 1 1 0 MYND finger Abhydrolase_1 PF00561.20 CCF52316.1 - 1.2e-10 41.5 0.0 3.5e-10 40.0 0.0 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CCF52316.1 - 3.9e-07 30.9 0.1 1.2e-06 29.3 0.0 1.8 2 0 0 2 2 2 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CCF52316.1 - 0.035 13.4 0.0 1.1 8.4 0.0 2.3 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Nas2_N PF18265.1 CCF52317.1 - 1e-18 67.0 0.1 1.6e-18 66.4 0.1 1.3 1 0 0 1 1 1 1 Nas2 N_terminal domain PDZ_6 PF17820.1 CCF52317.1 - 6.9e-07 29.0 0.6 3.3e-06 26.9 0.4 2.3 2 0 0 2 2 2 1 PDZ domain PDZ_2 PF13180.6 CCF52317.1 - 2.2e-06 27.9 0.1 5e-06 26.7 0.1 1.7 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 CCF52317.1 - 3.1e-05 24.2 0.0 6.7e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 PDZ domain GRASP55_65 PF04495.14 CCF52317.1 - 0.00038 20.8 0.0 0.00085 19.7 0.0 1.5 1 1 0 1 1 1 1 GRASP55/65 PDZ-like domain Na_H_Exchanger PF00999.21 CCF52318.1 - 1.6e-43 148.9 16.2 2.2e-43 148.5 16.2 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family Hid1 PF12722.7 CCF52318.1 - 0.4 8.7 6.2 0.57 8.2 6.2 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Glyco_hydro_42 PF02449.15 CCF52319.1 - 7.2e-115 384.3 3.3 9.4e-115 383.9 3.3 1.1 1 0 0 1 1 1 1 Beta-galactosidase Glyco_hydro_42M PF08532.10 CCF52319.1 - 8.6e-27 94.0 0.0 1.3e-26 93.4 0.0 1.3 1 0 0 1 1 1 1 Beta-galactosidase trimerisation domain Glyco_hydro_42C PF08533.10 CCF52319.1 - 0.00061 19.4 0.0 0.0012 18.5 0.0 1.5 1 0 0 1 1 1 1 Beta-galactosidase C-terminal domain Glyco_hydro_35 PF01301.19 CCF52319.1 - 0.0077 15.9 1.3 0.025 14.2 0.2 2.2 2 1 0 2 2 2 1 Glycosyl hydrolases family 35 Cellulase PF00150.18 CCF52319.1 - 0.038 13.4 0.1 0.075 12.4 0.1 1.4 1 0 0 1 1 1 0 Cellulase (glycosyl hydrolase family 5) Methyltransf_12 PF08242.12 CCF52320.1 - 1.1e-08 35.7 0.0 2.8e-08 34.4 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF52320.1 - 5e-08 33.5 0.0 1.4e-07 32.1 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCF52320.1 - 2.3e-07 30.8 0.0 3.5e-07 30.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF52320.1 - 9.5e-07 29.4 0.0 1.1e-05 26.0 0.0 2.6 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_28 PF02636.17 CCF52320.1 - 0.0033 17.1 0.0 0.006 16.2 0.0 1.4 1 1 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_31 PF13847.6 CCF52320.1 - 0.14 12.0 0.0 0.93 9.3 0.0 2.1 2 0 0 2 2 2 0 Methyltransferase domain Pox_MCEL PF03291.16 CCF52322.1 - 1.3e-76 257.9 0.0 2e-76 257.3 0.0 1.3 1 0 0 1 1 1 1 mRNA capping enzyme Methyltransf_25 PF13649.6 CCF52322.1 - 2.3e-09 37.8 0.0 4.9e-09 36.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF52322.1 - 5.2e-07 29.6 0.0 9.8e-07 28.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF52322.1 - 3.5e-06 27.7 0.0 9.1e-06 26.3 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF52322.1 - 1.6e-05 25.4 0.0 3.4e-05 24.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCF52322.1 - 6.5e-05 22.8 0.0 0.00014 21.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain CTP_transf_like PF01467.26 CCF52323.1 - 6.5e-27 94.5 0.0 1e-26 93.9 0.0 1.3 1 0 0 1 1 1 1 Cytidylyltransferase-like tRNA-synt_1 PF00133.22 CCF52324.1 - 1e-153 512.8 0.0 2.5e-153 511.5 0.0 1.5 1 1 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 CCF52324.1 - 3.6e-23 82.2 0.0 7.6e-23 81.2 0.0 1.5 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 CCF52324.1 - 8.5e-21 74.1 0.1 1.8e-12 46.7 0.0 3.8 3 1 0 3 3 3 3 tRNA synthetases class I (M) tRNA-synt_1_2 PF13603.6 CCF52324.1 - 0.001 18.6 0.0 0.0022 17.5 0.0 1.5 1 0 0 1 1 1 1 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1e PF01406.19 CCF52324.1 - 0.085 12.2 0.0 4 6.7 0.0 2.3 2 0 0 2 2 2 0 tRNA synthetases class I (C) catalytic domain Zn_clus PF00172.18 CCF52325.1 - 2e-05 24.6 7.1 3.8e-05 23.7 7.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MA3 PF02847.17 CCF52326.1 - 2e-29 101.9 0.1 3.7e-29 101.0 0.1 1.5 1 0 0 1 1 1 1 MA3 domain MIF4G PF02854.19 CCF52326.1 - 1.5e-13 50.9 2.6 4.9e-13 49.2 0.0 2.3 2 1 0 2 2 2 1 MIF4G domain Cnd1 PF12717.7 CCF52326.1 - 0.041 13.9 0.1 0.091 12.8 0.1 1.5 1 0 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1 COX6B PF02297.17 CCF52327.1 - 2.3e-26 91.8 4.2 4.5e-26 90.9 4.2 1.4 1 1 0 1 1 1 1 Cytochrome oxidase c subunit VIb DUF1100 PF06500.11 CCF52328.1 - 1.7e-05 23.8 0.0 4.3e-05 22.5 0.0 1.5 2 0 0 2 2 2 1 Alpha/beta hydrolase of unknown function (DUF1100) Hydrolase_4 PF12146.8 CCF52328.1 - 4.9e-05 22.7 0.0 0.00022 20.6 0.0 2.0 1 1 1 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 CCF52328.1 - 0.00022 21.0 0.0 0.007 16.0 0.0 2.5 1 1 1 2 2 2 1 alpha/beta hydrolase fold Peptidase_S15 PF02129.18 CCF52328.1 - 0.014 15.0 0.1 0.019 14.5 0.1 1.4 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) zf-Tim10_DDP PF02953.15 CCF52329.1 - 8.4e-18 63.8 0.4 1e-17 63.5 0.4 1.1 1 0 0 1 1 1 1 Tim10/DDP family zinc finger Sugar_tr PF00083.24 CCF52330.1 - 5.7e-116 388.1 20.0 6.6e-116 387.8 20.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF52330.1 - 3.4e-17 62.4 38.9 2.6e-16 59.5 34.1 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_5 PF05631.14 CCF52330.1 - 0.00097 18.2 0.6 0.0023 16.9 0.0 1.8 2 0 0 2 2 2 1 Sugar-tranasporters, 12 TM TRI12 PF06609.13 CCF52330.1 - 0.083 11.3 7.7 0.013 14.0 3.2 1.8 2 0 0 2 2 2 0 Fungal trichothecene efflux pump (TRI12) DUF2530 PF10745.9 CCF52330.1 - 0.5 10.6 8.8 0.062 13.5 3.3 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2530) zf-C2H2 PF00096.26 CCF52331.1 - 1.5e-07 31.4 10.3 0.00068 19.9 1.8 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 CCF52331.1 - 0.0013 19.0 4.0 0.0013 19.0 4.0 2.3 2 0 0 2 2 2 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 CCF52331.1 - 0.0015 19.2 9.7 0.1 13.5 1.6 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_5 PF13909.6 CCF52331.1 - 6.5 6.6 6.0 8 6.3 1.4 2.5 2 0 0 2 2 2 0 C2H2-type zinc-finger domain PEP_hydrolase PF09370.10 CCF52332.1 - 1.3e-127 424.5 0.3 1.5e-127 424.4 0.3 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate hydrolase-like NMO PF03060.15 CCF52332.1 - 0.13 11.6 0.1 0.13 11.6 0.1 1.6 2 0 0 2 2 2 0 Nitronate monooxygenase UPF0261 PF06792.11 CCF52333.1 - 1.2e-145 485.5 0.0 1.4e-145 485.3 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0261) RVT_2 PF07727.14 CCF52335.1 - 8.5e-17 61.6 0.0 1.2e-16 61.2 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) YwqJ-deaminase PF14431.6 CCF52335.1 - 0.039 14.1 0.0 0.053 13.7 0.0 1.2 1 0 0 1 1 1 0 YwqJ-like deaminase rve PF00665.26 CCF52336.1 - 1.2e-12 48.1 0.1 2.1e-12 47.3 0.1 1.4 1 0 0 1 1 1 1 Integrase core domain gag_pre-integrs PF13976.6 CCF52336.1 - 0.001 18.9 0.0 0.0029 17.4 0.0 1.7 1 0 0 1 1 1 1 GAG-pre-integrase domain rve_3 PF13683.6 CCF52336.1 - 0.0017 18.1 0.0 0.0044 16.8 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain PPR_2 PF13041.6 CCF52337.1 - 0.00019 21.5 0.2 0.0047 17.1 0.0 3.2 4 0 0 4 4 4 1 PPR repeat family DUF494 PF04361.13 CCF52337.1 - 0.015 15.2 1.0 0.28 11.1 0.1 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF494) Clathrin_H_link PF13838.6 CCF52337.1 - 0.093 12.7 0.1 0.29 11.1 0.0 1.9 2 0 0 2 2 2 0 Clathrin-H-link Asp PF00026.23 CCF52338.1 - 1.2e-68 231.9 4.3 1.9e-68 231.2 4.3 1.3 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 CCF52338.1 - 1.5e-10 41.6 2.3 1.5e-10 41.6 2.3 3.1 2 1 0 2 2 2 1 Xylanase inhibitor N-terminal tRNA-synt_1g PF09334.11 CCF52339.1 - 3.9e-86 289.3 0.5 1.1e-75 254.8 0.0 2.9 2 1 0 2 2 2 2 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 CCF52339.1 - 7.9e-20 70.6 0.0 1.2e-09 37.0 0.0 2.3 2 1 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1e PF01406.19 CCF52339.1 - 2.2e-10 40.4 0.1 1e-05 25.1 0.0 3.0 3 0 0 3 3 3 2 tRNA synthetases class I (C) catalytic domain DUF1641 PF07849.11 CCF52340.1 - 0.1 12.5 0.0 0.17 11.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1641) Proteasome PF00227.26 CCF52341.1 - 4.6e-58 195.8 0.3 6.1e-58 195.4 0.3 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 CCF52341.1 - 2.5e-14 52.6 0.2 5.4e-14 51.6 0.2 1.6 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature DUF5624 PF18538.1 CCF52341.1 - 0.029 14.4 0.8 0.055 13.6 0.2 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF5624) Ras PF00071.22 CCF52342.1 - 6.3e-46 155.9 0.0 7.3e-46 155.7 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CCF52342.1 - 2.7e-15 56.7 0.0 3.8e-15 56.2 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CCF52342.1 - 6.5e-07 29.0 0.0 7.5e-07 28.8 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 CCF52342.1 - 0.00052 20.0 0.0 0.79 9.6 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 CCF52342.1 - 0.00055 19.5 0.0 0.0016 18.0 0.0 1.7 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 CCF52342.1 - 0.0012 19.0 0.0 0.0018 18.4 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 CCF52342.1 - 0.042 13.3 0.0 0.051 13.0 0.0 1.1 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit ParG PF09274.10 CCF52343.1 - 0.094 12.9 0.0 0.33 11.1 0.0 1.9 1 0 0 1 1 1 0 ParG DUF4776 PF16003.5 CCF52343.1 - 0.78 8.7 7.4 1.6 7.6 7.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4776) ALMT PF11744.8 CCF52343.1 - 1.5 7.6 4.4 2.4 6.9 4.4 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter PMC2NT PF08066.12 CCF52343.1 - 2.9 8.6 6.3 52 4.6 0.0 4.0 5 1 0 5 5 5 0 PMC2NT (NUC016) domain DUF2052 PF09747.9 CCF52343.1 - 6 6.9 9.7 2.9 8.0 5.9 2.2 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) Apt1 PF10351.9 CCF52345.1 - 9.4e-134 446.9 0.4 9.4e-134 446.9 0.4 4.0 4 0 0 4 4 4 1 Golgi-body localisation protein domain Fmp27_WPPW PF10359.9 CCF52345.1 - 2.7e-65 221.1 0.0 5.7e-65 220.0 0.0 1.6 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain Fmp27_GFWDK PF10347.9 CCF52345.1 - 4.2e-49 166.7 0.0 7.8e-49 165.8 0.0 1.5 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain DUF2405 PF10293.9 CCF52345.1 - 4.6e-41 140.3 0.0 1.1e-40 139.0 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF2405) Fmp27_SW PF10305.9 CCF52345.1 - 5.5e-26 91.3 0.0 2.5e-25 89.1 0.0 2.3 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain Prefoldin_2 PF01920.20 CCF52346.1 - 0.003 17.5 0.2 0.003 17.5 0.2 1.5 2 0 0 2 2 2 1 Prefoldin subunit TauD PF02668.16 CCF52347.1 - 1.3e-36 126.8 0.0 3.9e-36 125.2 0.0 1.7 1 1 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family DUF971 PF06155.12 CCF52347.1 - 3.6e-12 46.7 0.1 5e-11 43.1 0.0 2.6 3 0 0 3 3 3 1 Protein of unknown function (DUF971) MACPF PF01823.19 CCF52347.1 - 0.012 15.8 4.5 0.47 10.5 0.4 2.2 2 0 0 2 2 2 0 MAC/Perforin domain CsiD PF08943.10 CCF52347.1 - 0.017 14.2 0.0 0.033 13.3 0.0 1.4 1 0 0 1 1 1 0 CsiD Retrotran_gag_3 PF14244.6 CCF52348.1 - 0.067 13.0 0.1 0.13 12.1 0.1 1.5 1 0 0 1 1 1 0 gag-polypeptide of LTR copia-type DUF3245 PF11595.8 CCF52348.1 - 0.3 11.5 3.9 2.1 8.8 3.6 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3245) PAS PF00989.25 CCF52349.1 - 1.3e-12 47.7 0.0 1.2e-10 41.3 0.0 2.9 2 1 0 2 2 2 1 PAS fold PAS_4 PF08448.10 CCF52349.1 - 1.6e-09 38.0 0.0 7.2e-07 29.4 0.0 2.7 2 0 0 2 2 2 2 PAS fold PAS_9 PF13426.7 CCF52349.1 - 3.3e-08 33.7 0.0 2.9e-05 24.3 0.0 2.5 2 0 0 2 2 2 2 PAS domain PAS_3 PF08447.12 CCF52349.1 - 2.3e-07 31.0 0.0 1.7e-06 28.2 0.0 2.4 1 1 0 1 1 1 1 PAS fold PAS_8 PF13188.7 CCF52349.1 - 0.016 15.2 0.0 0.041 13.9 0.0 1.6 1 0 0 1 1 1 0 PAS domain PAS_2 PF08446.11 CCF52349.1 - 0.082 13.6 0.0 10 6.8 0.0 2.5 2 0 0 2 2 2 0 PAS fold Fusion_gly PF00523.18 CCF52350.1 - 0.019 13.2 0.0 0.028 12.7 0.0 1.2 1 0 0 1 1 1 0 Fusion glycoprotein F0 FliT PF05400.13 CCF52350.1 - 0.57 11.0 4.1 0.19 12.5 0.9 1.9 2 0 0 2 2 2 0 Flagellar protein FliT STAG PF08514.11 CCF52351.1 - 1.2e-33 115.4 2.1 1.2e-33 115.4 2.1 3.5 3 0 0 3 3 3 1 STAG domain Cnd1 PF12717.7 CCF52351.1 - 0.0043 17.1 0.8 1.9 8.5 0.0 3.2 1 1 1 2 2 2 2 non-SMC mitotic condensation complex subunit 1 V-ATPase_H_N PF03224.14 CCF52351.1 - 0.043 13.1 1.2 0.08 12.2 0.0 2.1 2 0 0 2 2 2 0 V-ATPase subunit H HEAT PF02985.22 CCF52351.1 - 0.1 12.9 1.9 13 6.4 0.0 4.4 5 0 0 5 5 5 0 HEAT repeat Sporozoite_P67 PF05642.11 CCF52351.1 - 1.7 6.6 25.4 0.15 10.1 6.2 2.4 2 0 0 2 2 2 0 Sporozoite P67 surface antigen DHHC PF01529.20 CCF52352.1 - 2.2e-12 47.2 0.2 8.1e-12 45.4 0.0 1.9 2 0 0 2 2 2 1 DHHC palmitoyltransferase Suf PF05843.14 CCF52353.1 - 6.7e-93 311.9 7.8 4.2e-88 296.2 0.0 4.7 5 0 0 5 5 5 2 Suppressor of forked protein (Suf) TPR_14 PF13428.6 CCF52353.1 - 1.5e-07 31.6 2.7 1.2 10.1 0.0 7.9 5 2 3 8 8 8 2 Tetratricopeptide repeat HAT PF02184.16 CCF52353.1 - 0.52 10.3 7.3 12 6.0 0.0 5.0 5 0 0 5 5 5 0 HAT (Half-A-TPR) repeat Rad52_Rad22 PF04098.15 CCF52354.1 - 0.0067 16.4 0.5 0.0067 16.4 0.5 2.1 2 0 0 2 2 2 1 Rad52/22 family double-strand break repair protein zf-C2H2_jaz PF12171.8 CCF52354.1 - 0.19 12.0 0.3 0.33 11.3 0.3 1.4 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding RGS-like PF09128.11 CCF52354.1 - 6.4 6.4 11.8 0.61 9.8 7.5 1.5 2 0 0 2 2 2 0 Regulator of G protein signalling-like domain TPR_1 PF00515.28 CCF52355.1 - 4.1e-47 156.2 31.7 4.2e-08 32.7 0.9 9.3 9 0 0 9 9 9 9 Tetratricopeptide repeat STI1 PF17830.1 CCF52355.1 - 2.7e-35 120.1 12.5 3.3e-19 68.6 1.4 3.1 2 0 0 2 2 2 2 STI1 domain TPR_2 PF07719.17 CCF52355.1 - 2.8e-35 117.6 32.1 4.2e-06 26.5 0.3 9.4 9 0 0 9 9 9 9 Tetratricopeptide repeat TPR_16 PF13432.6 CCF52355.1 - 6.8e-22 77.8 17.1 8.3e-07 29.6 0.1 6.3 3 3 3 6 6 6 4 Tetratricopeptide repeat TPR_8 PF13181.6 CCF52355.1 - 1.5e-21 74.7 25.3 0.00047 20.2 0.5 9.1 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_11 PF13414.6 CCF52355.1 - 1.3e-19 69.5 24.5 5.9e-08 32.3 0.0 8.0 6 3 2 8 8 8 6 TPR repeat TPR_12 PF13424.6 CCF52355.1 - 7.5e-19 67.8 18.9 1.3e-09 38.2 0.5 7.1 5 2 2 7 7 7 3 Tetratricopeptide repeat TPR_19 PF14559.6 CCF52355.1 - 3.2e-15 56.4 16.6 6e-05 23.5 0.3 6.2 6 1 1 7 7 5 4 Tetratricopeptide repeat TPR_14 PF13428.6 CCF52355.1 - 8.8e-15 54.2 14.0 0.32 11.9 0.0 8.9 4 3 5 9 9 9 4 Tetratricopeptide repeat TPR_7 PF13176.6 CCF52355.1 - 2e-12 46.2 9.6 0.00058 19.7 0.1 7.2 7 1 1 8 8 8 2 Tetratricopeptide repeat TPR_17 PF13431.6 CCF52355.1 - 3.2e-10 39.7 4.4 0.24 11.9 0.0 6.1 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_10 PF13374.6 CCF52355.1 - 1.3e-09 37.6 14.6 0.0013 18.6 0.1 8.7 8 1 1 9 9 9 1 Tetratricopeptide repeat TPR_9 PF13371.6 CCF52355.1 - 2.1e-07 31.0 4.1 0.19 11.9 0.0 6.1 3 1 3 6 6 6 3 Tetratricopeptide repeat ANAPC3 PF12895.7 CCF52355.1 - 2.4e-05 24.4 15.7 0.012 15.8 2.6 4.4 3 1 0 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 CCF52355.1 - 8e-05 23.0 13.1 0.31 11.8 0.0 7.5 8 0 0 8 8 7 1 Tetratricopeptide repeat NARP1 PF12569.8 CCF52355.1 - 0.011 14.7 0.5 0.011 14.7 0.5 4.3 3 2 1 5 5 5 0 NMDA receptor-regulated protein 1 DUF3808 PF10300.9 CCF52355.1 - 0.011 14.5 1.4 0.013 14.3 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3808) GerD PF17898.1 CCF52355.1 - 0.034 14.1 3.5 0.32 11.0 1.0 3.0 2 1 0 2 2 2 0 Spore germination GerD central core domain TPR_3 PF07720.12 CCF52355.1 - 0.22 11.6 15.2 1.4 9.0 0.2 5.1 5 0 0 5 5 5 0 Tetratricopeptide repeat PAS_4 PF08448.10 CCF52355.1 - 0.26 11.6 0.7 3.6 7.9 0.0 2.9 3 0 0 3 3 3 0 PAS fold Glyco_transf_28 PF03033.20 CCF52356.1 - 1.6e-28 99.5 0.0 4.3e-28 98.1 0.0 1.8 1 0 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain GRAM PF02893.20 CCF52356.1 - 4.7e-17 61.9 0.0 2.3e-10 40.4 0.0 3.3 3 0 0 3 3 3 2 GRAM domain PH PF00169.29 CCF52356.1 - 7.6e-11 42.5 0.1 1.9e-10 41.2 0.1 1.7 1 0 0 1 1 1 1 PH domain SDA1 PF05285.12 CCF52356.1 - 0.00016 21.2 18.9 0.00016 21.2 18.9 3.1 4 0 0 4 4 4 1 SDA1 PH_6 PF15406.6 CCF52356.1 - 0.00023 21.4 0.0 0.00023 21.4 0.0 2.9 3 0 0 3 3 2 1 Pleckstrin homology domain UDPGT PF00201.18 CCF52356.1 - 0.00038 19.4 0.0 0.00065 18.6 0.0 1.3 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase PH_3 PF14593.6 CCF52356.1 - 0.00073 19.6 0.0 0.0015 18.6 0.0 1.4 1 0 0 1 1 1 1 PH domain Tim54 PF11711.8 CCF52356.1 - 0.3 9.8 19.5 0.014 14.2 13.0 2.0 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 D123 PF07065.14 CCF52356.1 - 0.44 9.6 8.3 1.2 8.3 8.3 1.6 1 0 0 1 1 1 0 D123 PH_11 PF15413.6 CCF52356.1 - 0.71 10.3 2.0 1.4 9.3 0.3 2.5 2 1 0 2 2 2 0 Pleckstrin homology domain Mpp10 PF04006.12 CCF52356.1 - 2.3 6.5 35.0 0.006 15.1 23.0 2.2 2 0 0 2 2 2 0 Mpp10 protein RNA_pol_3_Rpc31 PF11705.8 CCF52357.1 - 3.3e-23 83.1 9.4 5.3e-23 82.5 9.4 1.3 1 0 0 1 1 1 1 DNA-directed RNA polymerase III subunit Rpc31 ALAD PF00490.21 CCF52358.1 - 8.5e-124 412.8 0.0 1e-123 412.6 0.0 1.0 1 0 0 1 1 1 1 Delta-aminolevulinic acid dehydratase SCP2 PF02036.17 CCF52359.1 - 2.9e-11 43.7 2.8 2e-06 28.2 0.4 2.1 1 1 1 2 2 2 2 SCP-2 sterol transfer family Acetyltransf_9 PF13527.7 CCF52361.1 - 0.1 12.7 0.0 0.13 12.3 0.0 1.1 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain MFS_1 PF07690.16 CCF52363.1 - 7.9e-45 153.3 45.8 7.9e-45 153.3 45.8 1.8 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 CCF52363.1 - 4.4e-19 68.3 18.3 4.4e-19 68.3 18.3 1.4 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) DUF3098 PF11297.8 CCF52363.1 - 0.55 9.9 6.2 4.6 6.9 0.0 3.8 3 1 1 4 4 4 0 Protein of unknown function (DUF3098) Insulin_TMD PF17870.1 CCF52363.1 - 0.92 9.6 0.0 0.92 9.6 0.0 4.9 5 0 0 5 5 5 0 Insulin receptor trans-membrane segment ATP-synt_F PF01990.17 CCF52365.1 - 6.8e-30 103.2 0.0 7.7e-30 103.1 0.0 1.0 1 0 0 1 1 1 1 ATP synthase (F/14-kDa) subunit DUF257 PF03192.13 CCF52365.1 - 0.0026 17.6 0.0 0.0033 17.3 0.0 1.1 1 0 0 1 1 1 1 Pyrococcus protein of unknown function, DUF257 Hist_deacetyl PF00850.19 CCF52366.1 - 9.2e-83 278.2 0.0 1.6e-82 277.4 0.0 1.4 1 0 0 1 1 1 1 Histone deacetylase domain NIL PF09383.10 CCF52366.1 - 0.11 12.4 0.0 0.31 10.9 0.0 1.7 1 0 0 1 1 1 0 NIL domain DUF2486 PF10667.9 CCF52366.1 - 0.68 10.1 28.8 1.3 9.2 28.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2486) GYF PF02213.16 CCF52367.1 - 8e-19 67.0 1.1 1.4e-18 66.3 1.1 1.4 1 0 0 1 1 1 1 GYF domain GYF_2 PF14237.6 CCF52367.1 - 0.0031 17.3 0.1 0.0068 16.2 0.1 1.6 1 0 0 1 1 1 1 GYF domain 2 DnaJ_C PF01556.18 CCF52368.1 - 1.5e-32 112.7 0.0 2e-32 112.3 0.0 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 CCF52368.1 - 4.1e-23 81.3 4.3 6.8e-23 80.6 4.3 1.4 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 CCF52368.1 - 3.1e-10 40.2 17.7 3.1e-10 40.2 17.7 2.2 3 0 0 3 3 3 1 DnaJ central domain LexA_DNA_bind PF01726.16 CCF52368.1 - 0.046 13.5 0.0 0.11 12.3 0.0 1.6 1 0 0 1 1 1 0 LexA DNA binding domain adh_short PF00106.25 CCF52370.1 - 4.6e-13 49.1 0.1 1.6e-10 40.8 0.1 3.0 2 1 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF52370.1 - 7.8e-10 38.7 0.2 3.9e-08 33.1 0.2 2.4 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase 3HCDH_N PF02737.18 CCF52370.1 - 0.00015 21.7 0.0 0.00026 21.0 0.0 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain KR PF08659.10 CCF52370.1 - 0.003 17.5 0.1 0.0067 16.4 0.1 1.6 1 0 0 1 1 1 1 KR domain ApbA PF02558.16 CCF52370.1 - 0.01 15.5 0.0 0.11 12.1 0.0 2.1 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA LMWPc PF01451.21 CCF52371.1 - 5.9e-34 117.5 0.0 6.8e-34 117.3 0.0 1.0 1 0 0 1 1 1 1 Low molecular weight phosphotyrosine protein phosphatase V-ATPase_H_N PF03224.14 CCF52371.1 - 0.17 11.2 0.0 0.23 10.7 0.0 1.1 1 0 0 1 1 1 0 V-ATPase subunit H Pet100 PF09803.9 CCF52372.1 - 9.5e-29 99.7 0.3 1.6e-28 99.0 0.3 1.3 1 0 0 1 1 1 1 Pet100 AAA_6 PF12774.7 CCF52374.1 - 1.8e-126 421.5 0.0 1.7e-125 418.4 0.0 2.6 2 1 0 2 2 2 1 Hydrolytic ATP binding site of dynein motor region DHC_N1 PF08385.12 CCF52374.1 - 7.4e-119 397.9 8.0 7.4e-119 397.9 8.0 2.9 3 0 0 3 3 3 1 Dynein heavy chain, N-terminal region 1 DHC_N2 PF08393.13 CCF52374.1 - 2.4e-118 395.7 2.8 2.4e-118 395.7 2.8 3.4 4 0 0 4 4 4 1 Dynein heavy chain, N-terminal region 2 AAA_7 PF12775.7 CCF52374.1 - 4.6e-42 143.6 0.0 9.3e-36 123.0 0.0 4.5 4 0 0 4 4 4 2 P-loop containing dynein motor region AAA_8 PF12780.7 CCF52374.1 - 4.1e-37 127.9 0.0 1.5e-36 126.1 0.0 2.1 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 AAA_5 PF07728.14 CCF52374.1 - 1.4e-27 96.4 0.0 2.1e-14 53.7 0.0 5.6 5 0 0 5 5 5 3 AAA domain (dynein-related subfamily) Dynein_AAA_lid PF17852.1 CCF52374.1 - 3.4e-16 59.5 0.0 1.6e-15 57.3 0.0 2.3 2 0 0 2 2 1 1 Dynein heavy chain AAA lid domain AAA PF00004.29 CCF52374.1 - 1.6e-11 44.8 0.0 0.0093 16.4 0.0 4.8 4 0 0 4 4 4 3 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 CCF52374.1 - 2.7e-11 43.9 6.4 0.0055 17.0 0.0 6.3 5 1 0 5 5 5 3 AAA domain AAA_16 PF13191.6 CCF52374.1 - 4.5e-09 36.9 0.3 1.4 9.3 0.0 6.7 4 1 1 5 5 5 1 AAA ATPase domain AAA_33 PF13671.6 CCF52374.1 - 4.6e-08 33.3 0.0 0.25 11.5 0.0 5.0 4 0 0 4 4 4 2 AAA domain AAA_18 PF13238.6 CCF52374.1 - 1.5e-07 32.0 0.0 1.5 9.4 0.0 5.1 4 0 0 4 4 4 2 AAA domain T2SSE PF00437.20 CCF52374.1 - 6.7e-06 25.4 0.0 0.041 13.0 0.0 3.6 3 0 0 3 3 3 1 Type II/IV secretion system protein AAA_19 PF13245.6 CCF52374.1 - 1.8e-05 25.1 3.2 0.3 11.4 0.0 5.2 4 1 1 5 5 5 1 AAA domain Mg_chelatase PF01078.21 CCF52374.1 - 0.00028 20.3 4.1 0.61 9.4 0.0 3.7 4 0 0 4 4 3 2 Magnesium chelatase, subunit ChlI AAA_30 PF13604.6 CCF52374.1 - 0.0003 20.6 7.1 4 7.1 0.0 5.8 5 1 0 5 5 5 1 AAA domain IstB_IS21 PF01695.17 CCF52374.1 - 0.00079 19.2 0.3 0.75 9.5 0.0 3.7 3 0 0 3 3 3 1 IstB-like ATP binding protein FtsK_SpoIIIE PF01580.18 CCF52374.1 - 0.0012 18.3 0.3 9.3 5.5 0.0 4.0 4 0 0 4 4 4 0 FtsK/SpoIIIE family Rad17 PF03215.15 CCF52374.1 - 0.0016 18.4 0.2 21 5.0 0.0 4.4 4 0 0 4 4 4 0 Rad17 P-loop domain AAA_29 PF13555.6 CCF52374.1 - 0.0042 16.8 0.1 7.6 6.4 0.0 3.7 3 0 0 3 3 3 0 P-loop containing region of AAA domain AAA_lid_1 PF17857.1 CCF52374.1 - 0.0048 17.1 0.0 0.018 15.3 0.0 2.0 1 0 0 1 1 1 1 AAA+ lid domain AAA_11 PF13086.6 CCF52374.1 - 0.0056 16.5 1.2 1.4 8.6 0.0 4.0 4 0 0 4 4 4 1 AAA domain RNA_helicase PF00910.22 CCF52374.1 - 0.011 16.1 0.0 9.9 6.6 0.0 4.1 4 0 0 4 4 4 0 RNA helicase AAA_25 PF13481.6 CCF52374.1 - 0.016 14.8 0.4 0.44 10.1 0.0 3.2 3 0 0 3 3 3 0 AAA domain ABC_tran PF00005.27 CCF52374.1 - 0.023 15.2 2.7 26 5.3 0.0 4.9 5 0 0 5 5 3 0 ABC transporter AAA_24 PF13479.6 CCF52374.1 - 0.054 13.2 1.8 20 4.8 0.0 4.4 5 0 0 5 5 5 0 AAA domain DUF3921 PF13060.6 CCF52374.1 - 0.066 13.3 0.7 0.34 11.0 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3921) LOH1CR12 PF10158.9 CCF52374.1 - 0.42 10.6 5.7 1.2 9.1 0.4 3.9 3 0 0 3 3 2 0 Tumour suppressor protein Pkinase PF00069.25 CCF52375.1 - 7.8e-51 173.0 0.0 1.2e-50 172.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF52375.1 - 3.4e-23 82.2 0.0 1.7e-22 80.0 0.0 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase Snurportin1 PF11538.8 CCF52375.1 - 0.0016 18.6 4.1 0.0016 18.6 4.1 2.2 2 0 0 2 2 2 1 Snurportin1 DASH_Spc19 PF08287.11 CCF52375.1 - 0.0025 17.7 2.6 0.0025 17.7 2.6 2.6 2 0 0 2 2 2 1 Spc19 Pox_ser-thr_kin PF05445.11 CCF52375.1 - 0.013 14.5 0.0 0.02 13.9 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase APH PF01636.23 CCF52375.1 - 0.27 11.1 8.7 4.8 7.0 7.7 2.7 2 1 0 2 2 2 0 Phosphotransferase enzyme family Peptidase_C2 PF00648.21 CCF52376.1 - 4.6e-20 71.8 0.0 1.1e-19 70.6 0.0 1.6 1 0 0 1 1 1 1 Calpain family cysteine protease Calpain_III PF01067.22 CCF52376.1 - 2.3e-14 53.9 0.0 0.00012 22.3 0.0 5.2 4 1 0 4 4 4 2 Calpain large subunit, domain III MIT PF04212.18 CCF52376.1 - 3.1e-08 33.6 0.4 0.00018 21.5 0.0 2.5 2 0 0 2 2 2 2 MIT (microtubule interacting and transport) domain DUF4706 PF15797.5 CCF52376.1 - 0.041 14.4 0.1 0.11 13.0 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4706) CarboxypepD_reg PF13620.6 CCF52376.1 - 0.067 13.5 0.8 11 6.4 0.0 3.4 2 1 0 2 2 2 0 Carboxypeptidase regulatory-like domain HA2 PF04408.23 CCF52377.1 - 3.5e-18 65.9 0.0 7.6e-18 64.8 0.0 1.6 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 CCF52377.1 - 5.1e-12 46.0 0.0 1.4e-11 44.6 0.0 1.8 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 CCF52377.1 - 7.3e-12 45.6 0.0 8.1e-11 42.3 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Snf7 PF03357.21 CCF52378.1 - 1.4e-18 67.1 12.3 1.4e-18 67.1 12.3 2.0 1 1 1 2 2 2 1 Snf7 KCNQC3-Ank-G_bd PF11956.8 CCF52378.1 - 0.095 13.0 3.2 0.28 11.5 3.2 1.8 1 0 0 1 1 1 0 Ankyrin-G binding motif of KCNQ2-3 Fib_alpha PF08702.10 CCF52378.1 - 6.4 7.0 9.5 0.3 11.3 0.2 2.9 1 1 1 3 3 3 0 Fibrinogen alpha/beta chain family Ribosomal_S30 PF04758.14 CCF52379.1 - 3.6e-29 100.7 7.5 4e-29 100.6 7.5 1.0 1 0 0 1 1 1 1 Ribosomal protein S30 S10_plectin PF03501.15 CCF52380.1 - 6.1e-42 141.6 0.1 7.4e-42 141.3 0.1 1.1 1 0 0 1 1 1 1 Plectin/S10 domain TrmB PF01978.19 CCF52380.1 - 0.14 12.0 0.0 0.25 11.2 0.0 1.5 1 1 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB GET2 PF08690.10 CCF52381.1 - 1.5 8.5 7.8 1.5 8.4 7.8 1.0 1 0 0 1 1 1 0 GET complex subunit GET2 SMYLE_N PF18615.1 CCF52381.1 - 3.8 7.0 7.1 4.6 6.7 7.1 1.0 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain Presenilin PF01080.17 CCF52381.1 - 7.8 5.1 7.2 8.4 5.0 7.2 1.0 1 0 0 1 1 1 0 Presenilin E1-E2_ATPase PF00122.20 CCF52383.1 - 1.1e-53 181.4 4.3 2.3e-53 180.4 0.7 2.6 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 CCF52383.1 - 3.6e-44 150.7 3.9 3.6e-44 150.7 3.9 2.0 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 CCF52383.1 - 4.1e-24 86.0 0.0 1.8e-23 83.9 0.0 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 CCF52383.1 - 9.5e-22 76.5 0.9 1.6e-21 75.8 0.1 1.9 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Cation_ATPase PF13246.6 CCF52383.1 - 2.4e-18 66.0 0.0 5.1e-18 64.9 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 CCF52383.1 - 5.3e-08 32.9 1.5 7e-06 26.0 0.9 2.3 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD PF12710.7 CCF52383.1 - 5.1e-07 30.3 0.0 1.1e-06 29.1 0.0 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase L31 PF09784.9 CCF52384.1 - 1.2e-41 141.2 0.3 1.3e-41 141.1 0.3 1.0 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L31 SNF2_N PF00176.23 CCF52385.1 - 1.1e-53 182.2 0.0 1.8e-53 181.5 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Rad54_N PF08658.10 CCF52385.1 - 2.4e-47 161.4 0.5 5e-47 160.4 0.1 1.7 2 0 0 2 2 2 1 Rad54 N terminal Helicase_C PF00271.31 CCF52385.1 - 2.7e-15 56.7 0.0 1e-14 54.8 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CCF52385.1 - 2.1e-08 34.3 0.0 4.3e-08 33.3 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 CCF52385.1 - 1.4e-06 27.7 0.0 7.7e-06 25.3 0.0 2.1 2 1 0 2 2 2 1 Class II histone deacetylase complex subunits 2 and 3 DEAD PF00270.29 CCF52385.1 - 5.2e-05 23.1 0.0 0.00092 19.0 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase AAA_22 PF13401.6 CCF52385.1 - 0.0049 17.1 0.2 3.1 8.1 0.0 3.3 2 1 0 2 2 2 1 AAA domain Nefa_Nip30_N PF10187.9 CCF52385.1 - 7.3 7.0 6.9 0.8 10.1 1.5 2.1 2 0 0 2 2 2 0 N-terminal domain of NEFA-interacting nuclear protein NIP30 Galactosyl_T PF01762.21 CCF52386.1 - 4.7e-10 39.6 0.7 0.00044 20.1 0.0 4.0 3 1 1 4 4 4 3 Galactosyltransferase Arrestin_C PF02752.22 CCF52387.1 - 7.3e-13 49.1 0.0 2.2e-12 47.6 0.0 1.8 1 0 0 1 1 1 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 CCF52387.1 - 0.061 13.4 0.2 7.8 6.6 0.0 3.0 2 1 0 2 2 2 0 Arrestin (or S-antigen), N-terminal domain DUF656 PF04920.12 CCF52387.1 - 0.31 11.0 0.8 8.2 6.4 0.0 2.9 2 1 1 3 3 3 0 Family of unknown function (DUF656) He_PIG PF05345.12 CCF52388.1 - 0.0022 18.1 0.0 0.0056 16.8 0.0 1.7 1 0 0 1 1 1 1 Putative Ig domain CitG PF01874.16 CCF52389.1 - 0.076 12.6 0.0 0.078 12.6 0.0 1.0 1 0 0 1 1 1 0 ATP:dephospho-CoA triphosphoribosyl transferase DUF3452 PF11934.8 CCF52389.1 - 0.1 12.2 0.5 0.15 11.6 0.3 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF3452) ADK PF00406.22 CCF52390.1 - 3.2e-57 192.9 0.0 4.1e-57 192.5 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 CCF52390.1 - 8.8e-22 78.0 0.2 2.2e-21 76.7 0.1 1.7 2 0 0 2 2 2 1 AAA domain ADK_lid PF05191.14 CCF52390.1 - 1.4e-16 60.2 0.0 3.5e-16 58.9 0.0 1.7 1 0 0 1 1 1 1 Adenylate kinase, active site lid AAA_33 PF13671.6 CCF52390.1 - 0.0005 20.3 0.0 0.00098 19.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 CCF52390.1 - 0.0058 17.2 0.0 0.028 15.0 0.0 2.1 2 1 0 2 2 2 1 AAA domain AAA PF00004.29 CCF52390.1 - 0.01 16.3 0.1 0.031 14.7 0.0 1.8 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Thymidylate_kin PF02223.17 CCF52390.1 - 0.019 14.7 0.1 2.7 7.6 0.0 3.0 2 1 0 3 3 3 0 Thymidylate kinase LPP PF04728.13 CCF52390.1 - 0.054 13.9 0.1 0.18 12.2 0.1 1.9 1 0 0 1 1 1 0 Lipoprotein leucine-zipper AAA_5 PF07728.14 CCF52390.1 - 0.11 12.5 0.0 0.23 11.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Apo-CII PF05355.11 CCF52390.1 - 0.13 12.5 0.9 0.51 10.5 0.0 2.3 3 0 0 3 3 3 0 Apolipoprotein C-II TPR_1 PF00515.28 CCF52391.1 - 1.3e-18 65.9 4.3 0.0066 16.2 0.0 7.7 8 1 0 8 8 8 5 Tetratricopeptide repeat TPR_2 PF07719.17 CCF52391.1 - 1.6e-18 65.3 11.4 0.034 14.3 0.1 8.3 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_14 PF13428.6 CCF52391.1 - 3.8e-12 45.9 24.7 0.053 14.4 0.3 9.2 5 1 4 9 9 8 5 Tetratricopeptide repeat TPR_16 PF13432.6 CCF52391.1 - 2.2e-11 44.2 17.3 0.0008 20.0 0.1 6.8 4 2 3 7 7 7 5 Tetratricopeptide repeat TPR_8 PF13181.6 CCF52391.1 - 4.6e-11 42.0 1.4 0.057 13.7 0.0 7.2 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_11 PF13414.6 CCF52391.1 - 2.9e-10 39.6 2.1 0.53 10.0 0.0 6.7 5 2 2 7 7 7 4 TPR repeat TPR_17 PF13431.6 CCF52391.1 - 2e-08 34.0 0.8 0.29 11.6 0.0 6.3 7 0 0 7 7 6 2 Tetratricopeptide repeat TPR_12 PF13424.6 CCF52391.1 - 1.8e-05 24.9 17.6 0.023 15.0 1.0 6.3 3 1 5 8 8 8 5 Tetratricopeptide repeat TPR_9 PF13371.6 CCF52391.1 - 0.00071 19.7 13.2 0.0015 18.7 1.8 4.2 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 CCF52391.1 - 0.0018 18.7 17.5 0.54 10.8 0.0 7.4 7 1 0 7 7 7 1 Tetratricopeptide repeat TPR_7 PF13176.6 CCF52391.1 - 0.0019 18.1 3.2 32 4.9 0.0 5.5 5 0 0 5 5 5 0 Tetratricopeptide repeat ANAPC3 PF12895.7 CCF52391.1 - 1.6 9.0 13.3 3.6 7.9 0.1 4.3 4 0 0 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 LysM PF01476.20 CCF52392.1 - 3e-13 49.6 0.0 1.3e-05 25.2 0.0 2.3 2 0 0 2 2 2 2 LysM domain CDC45 PF02724.14 CCF52392.1 - 0.28 9.4 11.1 0.33 9.2 11.1 1.3 1 0 0 1 1 1 0 CDC45-like protein Otopetrin PF03189.13 CCF52392.1 - 2.3 6.9 8.2 3.3 6.4 8.2 1.5 1 0 0 1 1 1 0 Otopetrin Macoilin PF09726.9 CCF52392.1 - 3.1 6.2 23.8 4 5.9 23.8 1.1 1 0 0 1 1 1 0 Macoilin family DUF4638 PF15472.6 CCF52392.1 - 5.6 6.6 16.5 8.5 6.0 16.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) PCRF PF03462.18 CCF52394.1 - 4.6e-41 140.8 0.5 4.6e-41 140.8 0.5 1.7 2 0 0 2 2 2 1 PCRF domain RF-1 PF00472.20 CCF52394.1 - 4.9e-36 123.2 2.1 1.1e-35 122.1 2.1 1.5 1 0 0 1 1 1 1 RF-1 domain HLH PF00010.26 CCF52395.1 - 1.9e-08 34.1 0.0 5.4e-08 32.7 0.0 1.9 1 1 0 1 1 1 1 Helix-loop-helix DNA-binding domain DUF5094 PF17015.5 CCF52395.1 - 0.36 10.9 5.3 0.49 10.5 4.6 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF5094) DUF2207 PF09972.9 CCF52395.1 - 0.57 8.9 1.3 0.81 8.4 1.3 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Carboxyl_trans PF01039.22 CCF52396.1 - 5.3e-139 464.0 0.1 6.7e-139 463.7 0.1 1.0 1 0 0 1 1 1 1 Carboxyl transferase domain MdcE PF06833.11 CCF52396.1 - 0.021 14.3 0.1 1.1 8.6 0.0 2.2 2 0 0 2 2 2 0 Malonate decarboxylase gamma subunit (MdcE) SopD PF11047.8 CCF52396.1 - 0.062 12.5 0.0 0.092 11.9 0.0 1.2 1 0 0 1 1 1 0 Salmonella outer protein D AAA PF00004.29 CCF52397.1 - 8.4e-13 48.9 0.0 2.4e-12 47.4 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 CCF52397.1 - 0.00016 21.7 0.0 0.00035 20.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.12 CCF52397.1 - 0.00018 21.3 0.0 0.00038 20.2 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_assoc_2 PF16193.5 CCF52397.1 - 0.00098 19.4 0.1 0.003 17.9 0.1 1.8 1 0 0 1 1 1 1 AAA C-terminal domain Rad17 PF03215.15 CCF52397.1 - 0.001 19.0 0.1 0.033 14.1 0.0 2.4 2 0 0 2 2 2 1 Rad17 P-loop domain AAA_16 PF13191.6 CCF52397.1 - 0.0017 18.8 0.0 0.087 13.2 0.0 3.0 1 1 1 2 2 2 1 AAA ATPase domain AAA_25 PF13481.6 CCF52397.1 - 0.0039 16.8 0.1 0.87 9.1 0.0 2.8 3 0 0 3 3 3 1 AAA domain AAA_18 PF13238.6 CCF52397.1 - 0.013 16.0 0.0 0.034 14.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 CCF52397.1 - 0.029 14.7 0.1 0.23 11.7 0.0 2.3 1 1 1 2 2 2 0 AAA domain AAA_28 PF13521.6 CCF52397.1 - 0.052 13.8 0.1 0.14 12.4 0.1 1.7 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 CCF52397.1 - 0.11 12.3 0.0 0.21 11.3 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_33 PF13671.6 CCF52397.1 - 0.11 12.7 0.0 0.29 11.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.22 CCF52397.1 - 0.12 11.6 0.0 0.22 10.7 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain ATPase PF06745.13 CCF52397.1 - 0.13 11.6 0.0 0.25 10.7 0.0 1.4 1 0 0 1 1 1 0 KaiC NTPase_1 PF03266.15 CCF52397.1 - 0.14 12.1 0.2 0.38 10.7 0.1 1.8 1 1 1 2 2 2 0 NTPase CHORD PF04968.12 CCF52398.1 - 4.5e-48 161.8 12.6 9.8e-24 83.9 1.0 2.4 2 0 0 2 2 2 2 CHORD CS PF04969.16 CCF52398.1 - 4.2e-07 30.9 0.0 7.7e-07 30.0 0.0 1.4 1 0 0 1 1 1 1 CS domain BTK PF00779.19 CCF52398.1 - 0.015 15.1 11.1 0.11 12.3 2.6 3.2 3 1 0 3 3 3 0 BTK motif ABC_tran_CTD PF16326.5 CCF52399.1 - 0.11 12.8 12.2 0.043 14.1 4.4 2.7 2 0 0 2 2 2 0 ABC transporter C-terminal domain GAS PF13851.6 CCF52399.1 - 1.1 8.6 8.5 4.7 6.5 0.1 3.0 2 1 1 3 3 3 0 Growth-arrest specific micro-tubule binding HAP1_N PF04849.13 CCF52399.1 - 1.2 8.3 13.2 0.67 9.1 0.6 3.0 3 0 0 3 3 3 0 HAP1 N-terminal conserved region Filament PF00038.21 CCF52399.1 - 1.4 8.4 8.6 0.61 9.6 4.7 2.1 2 0 0 2 2 2 0 Intermediate filament protein DUF724 PF05266.14 CCF52399.1 - 1.4 8.7 4.7 2.2 8.1 1.5 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF724) TPR_MLP1_2 PF07926.12 CCF52399.1 - 5.9 7.0 14.4 0.19 11.8 1.7 2.9 2 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein Fungal_trans PF04082.18 CCF52401.1 - 5.6e-20 71.5 0.0 8.8e-20 70.8 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF52401.1 - 2.3e-06 27.6 8.7 4.7e-06 26.6 8.7 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain KAR PF15222.6 CCF52401.1 - 0.12 12.6 0.0 0.37 11.1 0.0 1.8 1 0 0 1 1 1 0 Kidney androgen-regulated Lactamase_B_2 PF12706.7 CCF52402.1 - 1.3e-20 73.8 0.0 2.8e-19 69.4 0.0 2.7 2 1 0 2 2 2 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 CCF52402.1 - 4.4e-06 26.7 0.0 9.4e-06 25.6 0.0 1.6 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 CCF52402.1 - 0.11 12.4 0.1 0.23 11.4 0.1 1.5 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily DUF4716 PF15837.5 CCF52402.1 - 1.5 9.0 3.5 0.92 9.6 0.4 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4716) GDP_Man_Dehyd PF16363.5 CCF52403.1 - 6.7e-49 167.1 0.1 1.7e-43 149.3 0.0 2.2 2 0 0 2 2 2 2 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 CCF52403.1 - 3.6e-44 151.0 0.0 5.7e-44 150.4 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 CCF52403.1 - 1.4e-09 37.4 0.0 3.2e-09 36.2 0.0 1.5 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 CCF52403.1 - 9.1e-08 31.6 0.0 0.00048 19.4 0.0 2.5 2 0 0 2 2 2 2 Male sterility protein RmlD_sub_bind PF04321.17 CCF52403.1 - 1.4e-05 24.3 0.0 2.3e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 CCF52403.1 - 1.8e-05 24.0 0.3 0.0038 16.4 0.1 3.1 3 1 0 3 3 3 1 Polysaccharide biosynthesis protein zf-Mss51 PF13824.6 CCF52404.1 - 8e-23 80.3 2.1 1.5e-22 79.4 2.1 1.5 1 0 0 1 1 1 1 Zinc-finger of mitochondrial splicing suppressor 51 zf-NADH-PPase PF09297.11 CCF52404.1 - 0.21 11.3 1.3 13 5.5 0.3 2.6 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain UEV PF05743.13 CCF52405.1 - 3.1e-34 117.4 0.0 4.9e-34 116.8 0.0 1.3 1 0 0 1 1 1 1 UEV domain Vps23_core PF09454.10 CCF52405.1 - 5.1e-28 96.8 0.5 9.3e-28 96.0 0.5 1.5 1 0 0 1 1 1 1 Vps23 core domain UQ_con PF00179.26 CCF52405.1 - 0.0054 16.4 0.0 0.012 15.3 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme THOC7 PF05615.13 CCF52405.1 - 0.061 13.6 0.1 0.1 12.9 0.1 1.3 1 0 0 1 1 1 0 Tho complex subunit 7 Baculo_PEP_C PF04513.12 CCF52405.1 - 0.084 12.9 0.7 0.19 11.8 0.7 1.5 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Seryl_tRNA_N PF02403.22 CCF52405.1 - 0.12 12.6 0.0 0.2 11.9 0.0 1.3 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain SAE2 PF08573.10 CCF52406.1 - 8e-07 30.2 0.2 8e-07 30.2 0.2 3.2 2 2 1 3 3 3 1 DNA repair protein endonuclease SAE2/CtIP C-terminus Cytochrom_C PF00034.21 CCF52406.1 - 0.03 15.5 0.7 0.12 13.6 0.7 2.0 1 0 0 1 1 1 0 Cytochrome c RasGEF PF00617.19 CCF52407.1 - 2.6e-59 200.4 0.7 4.9e-59 199.5 0.0 1.8 2 0 0 2 2 2 1 RasGEF domain RasGEF_N PF00618.20 CCF52407.1 - 1.2e-29 102.6 1.9 1.1e-28 99.5 0.6 2.7 2 0 0 2 2 2 1 RasGEF N-terminal motif SH3_1 PF00018.28 CCF52407.1 - 6.4e-14 51.3 0.1 1.2e-13 50.4 0.1 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 CCF52407.1 - 2e-10 40.3 0.1 3.9e-10 39.4 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 CCF52407.1 - 2.5e-10 39.9 0.0 4.8e-10 39.0 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain WW PF00397.26 CCF52407.1 - 0.006 16.6 5.6 0.64 10.2 0.3 2.6 2 0 0 2 2 2 2 WW domain 5_3_exonuc PF01367.20 CCF52407.1 - 0.21 12.2 0.3 1.9 9.1 0.0 2.5 2 0 0 2 2 2 0 5'-3' exonuclease, C-terminal SAM fold kleA_kleC PF17383.2 CCF52407.1 - 0.23 11.8 3.9 0.26 11.6 0.3 2.8 2 0 0 2 2 2 0 Uncharacterized KorC regulated protein A Sec66 PF09802.9 CCF52408.1 - 1.4e-52 177.9 0.8 1.7e-52 177.6 0.0 1.4 2 0 0 2 2 2 1 Preprotein translocase subunit Sec66 TPR_6 PF13174.6 CCF52408.1 - 2.2 9.1 6.1 1.4e+02 3.4 2.6 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat Pkinase_Tyr PF07714.17 CCF52410.1 - 1.9e-44 151.9 0.0 2.7e-44 151.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 CCF52410.1 - 1e-42 146.3 0.0 1.6e-42 145.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.23 CCF52410.1 - 0.23 11.4 0.0 0.23 11.4 0.0 2.9 4 0 0 4 4 4 0 Phosphotransferase enzyme family TEA PF01285.18 CCF52411.1 - 6.2e-27 93.5 0.0 1.2e-26 92.6 0.0 1.5 1 0 0 1 1 1 1 TEA/ATTS domain TFIIF_alpha PF05793.12 CCF52411.1 - 1.6 7.2 7.7 9.7 4.6 3.3 2.3 2 0 0 2 2 2 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) PGA2 PF07543.12 CCF52412.1 - 1.1 9.2 7.7 31 4.5 7.2 2.3 2 0 0 2 2 2 0 Protein trafficking PGA2 Flot PF15975.5 CCF52412.1 - 2.6 8.3 12.9 4.6 7.4 12.9 1.4 1 0 0 1 1 1 0 Flotillin Macoilin PF09726.9 CCF52412.1 - 4.9 5.6 5.9 7.3 5.0 5.9 1.2 1 0 0 1 1 1 0 Macoilin family P34-Arc PF04045.14 CCF52413.1 - 5.3e-107 357.0 0.0 6.3e-107 356.7 0.0 1.0 1 0 0 1 1 1 1 Arp2/3 complex, 34 kD subunit p34-Arc Lactamase_B_3 PF13483.6 CCF52414.1 - 9.8e-06 25.6 0.1 0.00018 21.4 0.1 2.2 1 1 0 1 1 1 1 Beta-lactamase superfamily domain TAP35_44 PF07265.11 CCF52414.1 - 0.068 13.2 0.5 0.2 11.7 0.2 1.8 2 0 0 2 2 2 0 Tapetum specific protein TAP35/TAP44 F-box-like PF12937.7 CCF52415.1 - 1.7e-07 31.0 1.5 3.1e-07 30.2 1.5 1.4 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 CCF52415.1 - 6.1e-05 22.8 0.2 0.00011 21.9 0.2 1.4 1 0 0 1 1 1 1 F-box domain Macoilin PF09726.9 CCF52415.1 - 0.2 10.2 5.9 0.27 9.7 5.9 1.2 1 0 0 1 1 1 0 Macoilin family fn3_2 PF16893.5 CCF52416.1 - 4.1e-38 129.4 0.2 7.4e-38 128.6 0.2 1.4 1 0 0 1 1 1 1 Fibronectin type III domain CHS5_N PF16892.5 CCF52416.1 - 4.9e-26 90.4 0.2 8.7e-26 89.6 0.2 1.4 1 0 0 1 1 1 1 Chitin biosynthesis protein CHS5 N-terminus fn3 PF00041.21 CCF52416.1 - 0.00018 21.8 0.1 0.00069 19.9 0.1 2.1 2 1 0 2 2 2 1 Fibronectin type III domain BRCT PF00533.26 CCF52416.1 - 0.00048 20.5 0.0 0.0009 19.6 0.0 1.4 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain DUF3006 PF11213.8 CCF52416.1 - 0.00079 19.6 0.1 0.0061 16.8 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF3006) PTCB-BRCT PF12738.7 CCF52416.1 - 0.003 17.5 0.0 0.013 15.5 0.0 2.1 1 1 0 1 1 1 1 twin BRCT domain CDC27 PF09507.10 CCF52416.1 - 0.077 12.4 5.7 0.11 11.9 5.7 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 SOBP PF15279.6 CCF52416.1 - 0.35 11.4 9.8 0.73 10.4 9.8 1.5 1 0 0 1 1 1 0 Sine oculis-binding protein Lactamase_B_6 PF16661.5 CCF52417.1 - 6.8e-49 165.9 0.0 1.1e-45 155.5 0.0 2.3 2 0 0 2 2 2 2 Metallo-beta-lactamase superfamily domain CPSF100_C PF13299.6 CCF52417.1 - 4.2e-33 114.9 0.4 2.1e-31 109.4 0.0 2.9 3 0 0 3 3 3 1 Cleavage and polyadenylation factor 2 C-terminal Beta-Casp PF10996.8 CCF52417.1 - 8.5e-19 67.9 0.0 4.4e-18 65.6 0.0 2.2 2 0 0 2 2 2 1 Beta-Casp domain RMMBL PF07521.12 CCF52417.1 - 0.00027 20.8 0.0 0.00081 19.3 0.0 1.9 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B_2 PF12706.7 CCF52417.1 - 0.00074 19.1 0.0 0.0018 17.9 0.0 1.6 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 CCF52417.1 - 0.11 12.5 0.3 0.75 9.8 0.3 2.4 1 1 0 1 1 1 0 Metallo-beta-lactamase superfamily MIP PF00230.20 CCF52418.1 - 2.1e-39 135.5 11.8 3.1e-39 135.0 11.8 1.2 1 0 0 1 1 1 1 Major intrinsic protein Peptidase_S8 PF00082.22 CCF52419.1 - 1.2e-38 133.1 0.9 2.1e-38 132.3 0.9 1.4 1 0 0 1 1 1 1 Subtilase family P_proprotein PF01483.20 CCF52419.1 - 1.4e-27 95.6 0.2 3.2e-27 94.4 0.2 1.7 1 0 0 1 1 1 1 Proprotein convertase P-domain S8_pro-domain PF16470.5 CCF52419.1 - 0.046 14.5 6.8 0.45 11.3 0.0 2.7 1 1 1 2 2 2 0 Peptidase S8 pro-domain DUF1356 PF07092.12 CCF52420.1 - 0.0007 18.9 0.5 0.0011 18.3 0.5 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1356) LEA_2 PF03168.13 CCF52420.1 - 0.0064 17.0 0.1 0.025 15.1 0.1 2.0 1 1 1 2 2 2 1 Late embryogenesis abundant protein ODV-E18 PF10717.9 CCF52420.1 - 0.039 13.8 0.4 0.089 12.7 0.4 1.6 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 Vps54 PF07928.12 CCF52421.1 - 2.2e-53 180.3 1.1 9.3e-53 178.3 1.1 2.2 1 0 0 1 1 1 1 Vps54-like protein Vps54_N PF10475.9 CCF52421.1 - 9.9e-06 25.0 2.7 9.9e-06 25.0 2.7 1.9 2 0 0 2 2 2 1 Vacuolar-sorting protein 54, of GARP complex TPR_19 PF14559.6 CCF52421.1 - 0.024 15.1 0.6 0.092 13.3 0.6 2.0 1 0 0 1 1 1 0 Tetratricopeptide repeat DUF2451 PF10474.9 CCF52421.1 - 0.053 13.3 2.9 0.042 13.6 0.7 1.9 2 0 0 2 2 2 0 Protein of unknown function C-terminus (DUF2451) Vps39_1 PF10366.9 CCF52421.1 - 0.075 13.3 0.1 0.23 11.7 0.1 1.8 1 0 0 1 1 1 0 Vacuolar sorting protein 39 domain 1 TPR_14 PF13428.6 CCF52421.1 - 0.17 12.8 3.5 0.23 12.4 0.2 3.1 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_4 PF07721.14 CCF52421.1 - 5.2 8.0 6.7 0.32 11.7 0.2 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat WD40 PF00400.32 CCF52422.1 - 4.8e-13 49.3 6.4 0.0034 18.2 0.0 5.0 4 0 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF52422.1 - 6.4e-09 36.0 0.0 0.074 13.4 0.0 3.3 2 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 CCF52422.1 - 0.16 11.8 0.0 0.35 10.7 0.0 1.5 1 0 0 1 1 1 0 Eukaryotic translation initiation factor eIF2A Exo_endo_phos PF03372.23 CCF52423.1 - 1.9e-20 73.4 0.1 2.5e-20 73.0 0.1 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family UQ_con PF00179.26 CCF52424.1 - 5.4e-38 129.8 0.1 7.1e-38 129.4 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UEV PF05743.13 CCF52424.1 - 0.028 14.3 0.0 0.039 13.8 0.0 1.3 1 0 0 1 1 1 0 UEV domain RWD PF05773.22 CCF52424.1 - 0.029 14.6 0.2 0.041 14.2 0.2 1.3 1 0 0 1 1 1 0 RWD domain PCMT PF01135.19 CCF52425.1 - 1.8e-65 220.7 0.0 2e-65 220.4 0.0 1.0 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_25 PF13649.6 CCF52425.1 - 1.8e-06 28.6 0.0 3.2e-06 27.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF52425.1 - 5.9e-06 26.2 0.0 8.4e-06 25.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF52425.1 - 0.0014 19.3 0.0 0.0026 18.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 CCF52425.1 - 0.0018 17.7 0.0 0.0026 17.2 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_32 PF13679.6 CCF52425.1 - 0.0063 16.5 0.0 0.0097 15.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCF52425.1 - 0.0087 15.9 0.0 0.012 15.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MetW PF07021.12 CCF52425.1 - 0.066 12.8 0.0 0.1 12.2 0.0 1.3 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW Methyltransf_18 PF12847.7 CCF52425.1 - 0.091 12.7 0.0 0.14 12.1 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Guanylate_kin PF00625.21 CCF52426.1 - 3.8e-58 196.2 0.0 4.6e-58 195.9 0.0 1.1 1 0 0 1 1 1 1 Guanylate kinase AAA_16 PF13191.6 CCF52426.1 - 3.1e-07 30.9 0.1 1e-06 29.3 0.1 1.8 1 1 0 1 1 1 1 AAA ATPase domain RsgA_GTPase PF03193.16 CCF52426.1 - 2.5e-05 24.2 0.0 3.9e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_22 PF13401.6 CCF52426.1 - 3.7e-05 24.0 0.0 0.00037 20.8 0.0 2.1 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 CCF52426.1 - 6.8e-05 22.9 0.0 0.0001 22.4 0.0 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_18 PF13238.6 CCF52426.1 - 0.00028 21.4 0.1 0.0032 18.0 0.0 2.4 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 CCF52426.1 - 0.00054 20.1 0.0 0.013 15.6 0.0 2.5 1 1 1 2 2 2 1 AAA domain ABC_tran PF00005.27 CCF52426.1 - 0.0011 19.5 0.0 0.0021 18.6 0.0 1.8 1 1 0 1 1 1 1 ABC transporter RNA_helicase PF00910.22 CCF52426.1 - 0.0032 17.8 0.0 0.0066 16.8 0.0 1.6 1 0 0 1 1 1 1 RNA helicase Thymidylate_kin PF02223.17 CCF52426.1 - 0.0036 17.0 0.0 0.0097 15.6 0.0 1.7 1 1 0 1 1 1 1 Thymidylate kinase ATPase_2 PF01637.18 CCF52426.1 - 0.0055 16.7 0.0 0.071 13.0 0.0 2.0 2 0 0 2 2 2 1 ATPase domain predominantly from Archaea AAA_28 PF13521.6 CCF52426.1 - 0.0056 16.9 0.0 0.037 14.3 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 CCF52426.1 - 0.0056 16.4 0.3 0.015 15.0 0.0 1.8 2 0 0 2 2 2 1 P-loop containing region of AAA domain NTPase_1 PF03266.15 CCF52426.1 - 0.0058 16.6 0.0 0.02 14.8 0.0 1.8 2 1 0 2 2 2 1 NTPase AAA_7 PF12775.7 CCF52426.1 - 0.0062 16.1 0.0 0.012 15.1 0.0 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region T2SSE PF00437.20 CCF52426.1 - 0.0072 15.4 0.0 0.011 14.8 0.0 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_24 PF13479.6 CCF52426.1 - 0.0083 15.9 0.0 0.17 11.6 0.0 2.1 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 CCF52426.1 - 0.0089 16.0 0.0 0.02 14.8 0.0 1.6 2 0 0 2 2 1 1 NACHT domain AAA_14 PF13173.6 CCF52426.1 - 0.0099 15.9 0.0 0.017 15.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain KAP_NTPase PF07693.14 CCF52426.1 - 0.013 14.8 0.1 0.033 13.4 0.0 1.9 1 1 0 1 1 1 0 KAP family P-loop domain AAA_5 PF07728.14 CCF52426.1 - 0.016 15.2 0.0 0.27 11.2 0.0 2.1 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) NB-ARC PF00931.22 CCF52426.1 - 0.025 13.8 0.0 0.17 11.0 0.0 2.0 2 0 0 2 2 2 0 NB-ARC domain Rad17 PF03215.15 CCF52426.1 - 0.05 13.5 0.0 0.076 12.9 0.0 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain AAA PF00004.29 CCF52426.1 - 0.068 13.6 0.0 0.19 12.2 0.0 1.8 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) dNK PF01712.19 CCF52426.1 - 0.075 12.9 0.0 1.3 8.8 0.0 2.1 2 0 0 2 2 2 0 Deoxynucleoside kinase Septin PF00735.18 CCF52426.1 - 0.1 11.8 0.0 0.16 11.2 0.0 1.3 1 0 0 1 1 1 0 Septin cobW PF02492.19 CCF52426.1 - 0.14 11.7 0.0 0.27 10.8 0.0 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain DUF2786 PF10979.8 CCF52427.1 - 1.2e-11 44.3 0.3 3.2e-11 43.0 0.3 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF2786) Prion_bPrPp PF11587.8 CCF52430.1 - 0.083 12.7 0.3 0.13 12.1 0.3 1.3 1 0 0 1 1 1 0 Major prion protein bPrPp - N terminal Nucleoporin_C PF03177.14 CCF52432.1 - 2.2e-115 386.7 0.0 2.9e-115 386.3 0.0 1.1 1 0 0 1 1 1 1 Non-repetitive/WGA-negative nucleoporin C-terminal Nucleoporin_N PF08801.11 CCF52432.1 - 1.1e-15 57.3 0.0 1.7e-15 56.8 0.0 1.2 1 0 0 1 1 1 1 Nup133 N terminal like PsbU PF06514.11 CCF52432.1 - 0.17 11.9 0.0 1 9.4 0.0 2.2 2 0 0 2 2 2 0 Photosystem II 12 kDa extrinsic protein (PsbU) WD40 PF00400.32 CCF52433.1 - 2.5e-22 78.8 25.6 2.9e-08 34.2 0.1 7.7 9 0 0 9 9 9 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF52433.1 - 1.2e-09 38.3 0.5 0.065 13.5 0.1 4.8 2 2 2 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CCF52433.1 - 0.00018 20.6 0.0 0.11 11.5 0.0 2.8 2 1 0 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 CCF52433.1 - 0.00022 21.1 0.0 0.093 12.6 0.0 2.3 2 0 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 CCF52433.1 - 0.013 15.5 0.0 5.9 7.0 0.0 4.0 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat LisH PF08513.11 CCF52433.1 - 0.043 13.8 0.0 0.09 12.8 0.0 1.6 1 0 0 1 1 1 0 LisH LisH_TPL PF17814.1 CCF52433.1 - 0.084 12.6 0.0 0.17 11.6 0.0 1.5 1 0 0 1 1 1 0 LisH-like dimerisation domain Fungal_trans PF04082.18 CCF52434.1 - 4.2e-14 52.2 0.0 5.7e-13 48.5 0.0 2.2 1 1 0 1 1 1 1 Fungal specific transcription factor domain zf-C2H2 PF00096.26 CCF52434.1 - 1.4e-05 25.3 7.0 0.0024 18.2 1.8 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CCF52434.1 - 0.0014 19.3 7.9 0.017 15.9 0.8 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_6 PF13912.6 CCF52434.1 - 0.23 11.5 3.4 1.4 9.0 0.1 2.4 2 0 0 2 2 2 0 C2H2-type zinc finger V-SNARE_C PF12352.8 CCF52435.1 - 1.3e-18 67.0 0.8 2.8e-18 66.0 0.8 1.6 1 0 0 1 1 1 1 Snare region anchored in the vesicle membrane C-terminus ABC_tran_CTD PF16326.5 CCF52435.1 - 0.19 12.0 3.2 0.26 11.6 0.6 2.5 3 0 0 3 3 3 0 ABC transporter C-terminal domain Baculo_PEP_C PF04513.12 CCF52435.1 - 3.3 7.7 6.0 22 5.1 0.7 2.8 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus CRM1_C PF08767.11 CCF52436.1 - 1.2e-129 432.1 3.1 3.2e-129 430.7 0.1 2.8 3 0 0 3 3 3 1 CRM1 C terminal Xpo1 PF08389.12 CCF52436.1 - 5.3e-40 136.9 0.7 5.3e-40 136.9 0.7 3.7 3 1 0 3 3 3 1 Exportin 1-like protein CRM1_repeat_2 PF18784.1 CCF52436.1 - 1e-33 114.8 4.7 2.3e-33 113.7 4.7 1.6 1 0 0 1 1 1 1 CRM1 / Exportin repeat 2 CRM1_repeat_3 PF18787.1 CCF52436.1 - 2.1e-31 107.8 1.2 9.5e-31 105.7 1.2 2.3 1 0 0 1 1 1 1 CRM1 / Exportin repeat 3 CRM1_repeat PF18777.1 CCF52436.1 - 1.5e-20 72.4 0.9 4.5e-20 70.9 0.9 1.9 1 0 0 1 1 1 1 Chromosome region maintenance or exportin repeat IBN_N PF03810.19 CCF52436.1 - 1.4e-15 56.9 2.7 3.7e-15 55.6 1.1 2.7 2 0 0 2 2 2 1 Importin-beta N-terminal domain Ank_2 PF12796.7 CCF52437.1 - 3.2e-50 168.7 1.8 2.1e-14 53.9 0.0 4.1 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CCF52437.1 - 1.7e-32 111.4 2.9 3.4e-09 37.1 0.0 5.6 3 2 2 5 5 5 5 Ankyrin repeats (many copies) SPX PF03105.19 CCF52437.1 - 6.9e-25 88.8 14.0 5e-09 36.6 0.8 3.3 1 1 2 3 3 3 3 SPX domain Ank PF00023.30 CCF52437.1 - 3.6e-22 77.8 5.1 0.0016 18.8 0.0 7.0 7 0 0 7 7 7 5 Ankyrin repeat Ank_3 PF13606.6 CCF52437.1 - 4.3e-21 72.8 4.0 0.0015 18.8 0.0 8.0 8 0 0 8 8 8 4 Ankyrin repeat Ank_5 PF13857.6 CCF52437.1 - 5.2e-20 71.2 5.5 0.011 16.1 0.0 6.4 1 1 5 7 7 7 7 Ankyrin repeats (many copies) GDPD PF03009.17 CCF52437.1 - 2.9e-11 43.6 0.0 1.4e-10 41.4 0.0 2.0 2 0 0 2 2 2 1 Glycerophosphoryl diester phosphodiesterase family Peripla_BP_2 PF01497.18 CCF52437.1 - 0.041 13.4 0.0 0.1 12.2 0.0 1.6 1 0 0 1 1 1 0 Periplasmic binding protein DUF2423 PF10338.9 CCF52438.1 - 7.7e-11 42.1 4.3 1.4e-10 41.3 4.3 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2423) Abhydrolase_1 PF00561.20 CCF52439.1 - 1.4e-05 24.9 0.1 0.00028 20.6 0.1 2.3 1 1 1 2 2 2 1 alpha/beta hydrolase fold DUF1749 PF08538.10 CCF52439.1 - 2e-05 23.8 0.0 3.1e-05 23.2 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1749) Hydrolase_4 PF12146.8 CCF52439.1 - 7.2e-05 22.2 0.0 0.0062 15.8 0.0 2.6 2 1 0 2 2 2 1 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 CCF52439.1 - 0.00083 18.9 0.0 0.02 14.4 0.0 2.2 2 0 0 2 2 2 1 Prolyl oligopeptidase family DUF915 PF06028.11 CCF52439.1 - 0.018 14.3 0.0 2 7.7 0.0 2.1 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF915) XPG_I PF00867.18 CCF52440.1 - 1.2e-19 70.4 0.0 3.5e-19 68.9 0.0 1.8 1 0 0 1 1 1 1 XPG I-region XPG_N PF00752.17 CCF52440.1 - 2.9e-06 27.7 0.0 7e-06 26.5 0.0 1.7 1 0 0 1 1 1 1 XPG N-terminal domain GEN1_C PF18380.1 CCF52440.1 - 2.8e-05 25.0 2.5 4.9e-05 24.2 0.0 2.4 2 1 0 2 2 2 1 Holliday junction resolvase Gen1 C-terminal domain XPG_I_2 PF12813.7 CCF52440.1 - 0.035 13.6 0.0 0.088 12.3 0.0 1.6 2 0 0 2 2 2 0 XPG domain containing DDE_Tnp_1_6 PF13751.6 CCF52440.1 - 0.08 13.2 0.0 0.16 12.2 0.0 1.4 1 0 0 1 1 1 0 Transposase DDE domain COesterase PF00135.28 CCF52441.1 - 2.9e-76 257.4 0.0 3.5e-38 131.7 0.0 2.9 2 1 0 2 2 2 2 Carboxylesterase family Abhydrolase_3 PF07859.13 CCF52441.1 - 1.2e-07 31.8 1.2 0.00036 20.5 0.2 2.3 2 0 0 2 2 2 2 alpha/beta hydrolase fold Fasciclin PF02469.22 CCF52442.1 - 2.2e-17 63.4 0.0 4.8e-10 39.7 0.0 3.5 3 1 0 3 3 3 3 Fasciclin domain bZIP_1 PF00170.21 CCF52443.1 - 1.2e-05 25.3 7.4 2e-05 24.6 7.4 1.3 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 CCF52443.1 - 0.0057 16.7 5.7 0.01 15.9 5.7 1.5 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.17 CCF52443.1 - 2.4 8.7 13.5 0.23 12.0 7.6 2.2 2 1 0 2 2 2 0 bZIP Maf transcription factor Glutaredoxin PF00462.24 CCF52444.1 - 4.2e-16 58.9 0.1 6.4e-16 58.3 0.1 1.3 1 0 0 1 1 1 1 Glutaredoxin GTP_EFTU PF00009.27 CCF52445.1 - 6.9e-47 159.5 0.0 1.1e-46 158.9 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFTUD2 PF16004.5 CCF52445.1 - 8.7e-37 126.4 4.1 1.4e-36 125.7 4.1 1.4 1 0 0 1 1 1 1 116 kDa U5 small nuclear ribonucleoprotein component N-terminus EFG_IV PF03764.18 CCF52445.1 - 2.7e-25 88.5 0.0 5.1e-25 87.6 0.0 1.5 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_C PF00679.24 CCF52445.1 - 1.4e-20 73.1 0.0 3.6e-20 71.8 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 CCF52445.1 - 2e-06 28.1 0.0 4.6e-06 26.9 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 CCF52445.1 - 3.4e-06 27.1 0.0 6.7e-06 26.2 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase EFG_II PF14492.6 CCF52445.1 - 1.2e-05 25.3 0.0 3.3e-05 23.9 0.0 1.8 1 0 0 1 1 1 1 Elongation Factor G, domain II Ras PF00071.22 CCF52445.1 - 0.00074 19.1 0.0 0.0021 17.7 0.0 1.7 1 1 0 1 1 1 1 Ras family Roc PF08477.13 CCF52445.1 - 0.0039 17.4 0.0 0.029 14.6 0.0 2.1 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase DUF1770 PF08589.10 CCF52445.1 - 0.0095 16.9 0.0 0.02 15.8 0.0 1.6 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1770) Septin PF00735.18 CCF52445.1 - 0.012 14.9 0.0 0.02 14.2 0.0 1.3 1 0 0 1 1 1 0 Septin Dynamin_N PF00350.23 CCF52445.1 - 0.15 12.1 0.0 2 8.5 0.0 2.2 1 1 1 2 2 2 0 Dynamin family MFS_2 PF13347.6 CCF52446.1 - 0.0012 17.5 4.1 0.0012 17.5 4.1 3.1 3 0 0 3 3 3 1 MFS/sugar transport protein MFS_1_like PF12832.7 CCF52446.1 - 0.01 14.8 0.0 0.019 13.8 0.0 1.5 1 1 0 1 1 1 0 MFS_1 like family PrgI PF12666.7 CCF52446.1 - 0.2 12.4 2.8 0.87 10.3 0.5 3.0 2 0 0 2 2 2 0 PrgI family protein PDCD2_C PF04194.13 CCF52447.1 - 2.6e-34 118.8 0.0 2.6e-34 118.8 0.0 4.1 4 0 0 4 4 4 2 Programmed cell death protein 2, C-terminal putative domain TFIIA PF03153.13 CCF52447.1 - 0.0022 18.0 1.8 0.0022 18.0 1.8 1.6 2 0 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit Nop14 PF04147.12 CCF52447.1 - 0.064 11.5 9.4 0.085 11.1 9.4 1.1 1 0 0 1 1 1 0 Nop14-like family zf-RRN7 PF11781.8 CCF52447.1 - 0.066 12.9 0.2 0.14 11.8 0.2 1.6 1 0 0 1 1 1 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 Cwf_Cwc_15 PF04889.12 CCF52447.1 - 1.1 9.0 22.9 0.78 9.4 5.1 2.4 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein 40S_SA_C PF16122.5 CCF52447.1 - 6.2 8.2 12.1 14 7.1 4.8 2.8 1 1 1 2 2 2 0 40S ribosomal protein SA C-terminus Cornichon PF03311.14 CCF52448.1 - 9.4e-53 177.7 12.6 1.1e-52 177.5 12.6 1.0 1 0 0 1 1 1 1 Cornichon protein DUF2189 PF09955.9 CCF52448.1 - 0.32 11.2 7.8 0.44 10.8 0.2 2.3 2 1 0 2 2 2 0 Predicted integral membrane protein (DUF2189) CT_A_B PF02626.15 CCF52449.1 - 4.2e-69 233.1 0.0 6.3e-69 232.5 0.0 1.3 1 0 0 1 1 1 1 Carboxyltransferase domain, subdomain A and B CPSase_L_D2 PF02786.17 CCF52449.1 - 7.8e-56 188.9 0.1 1.4e-55 188.1 0.1 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.22 CCF52449.1 - 1.7e-35 121.9 0.0 8.4e-35 119.6 0.0 2.2 2 0 0 2 2 2 1 Biotin carboxylase, N-terminal domain CT_C_D PF02682.16 CCF52449.1 - 3.2e-31 108.6 0.0 7.5e-31 107.5 0.0 1.6 1 0 0 1 1 1 1 Carboxyltransferase domain, subdomain C and D Biotin_carb_C PF02785.19 CCF52449.1 - 8.4e-28 96.6 0.0 6.6e-27 93.7 0.0 2.3 2 0 0 2 2 2 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.22 CCF52449.1 - 2.3e-12 46.6 0.7 6.9e-12 45.0 0.7 1.8 1 0 0 1 1 1 1 Biotin-requiring enzyme Dala_Dala_lig_C PF07478.13 CCF52449.1 - 3.6e-10 39.7 0.0 9.6e-10 38.3 0.0 1.8 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 CCF52449.1 - 8.4e-07 28.7 0.0 2.3e-06 27.3 0.0 1.7 1 0 0 1 1 1 1 ATP-grasp domain RimK PF08443.11 CCF52449.1 - 6.1e-05 22.7 0.0 0.00062 19.4 0.0 2.4 2 1 0 2 2 2 1 RimK-like ATP-grasp domain ATP-grasp_3 PF02655.14 CCF52449.1 - 0.0001 22.4 0.0 0.00022 21.3 0.0 1.6 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_5 PF13549.6 CCF52449.1 - 0.00045 19.7 0.0 0.00095 18.7 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_4 PF13535.6 CCF52449.1 - 0.013 15.1 0.0 0.03 13.9 0.0 1.7 1 0 0 1 1 1 0 ATP-grasp domain GARS_A PF01071.19 CCF52449.1 - 0.032 14.0 0.0 0.062 13.1 0.0 1.5 1 0 0 1 1 1 0 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain LamB_YcsF PF03746.16 CCF52450.1 - 2.4e-84 282.7 0.0 2.8e-84 282.5 0.0 1.0 1 0 0 1 1 1 1 LamB/YcsF family B56 PF01603.20 CCF52451.1 - 1.6e-193 643.3 10.3 1.9e-193 643.1 10.3 1.0 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) Prenyltrans PF00432.21 CCF52452.1 - 0.11 12.2 0.6 2.9 7.7 0.2 2.3 2 0 0 2 2 2 0 Prenyltransferase and squalene oxidase repeat RQC PF09382.10 CCF52453.1 - 1.1e-25 89.7 0.1 1.9e-25 88.9 0.1 1.4 1 0 0 1 1 1 1 RQC domain DEAD PF00270.29 CCF52453.1 - 2.2e-20 73.1 0.0 5.5e-20 71.9 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CCF52453.1 - 3.9e-19 69.0 0.0 1.5e-17 64.0 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain RecQ_Zn_bind PF16124.5 CCF52453.1 - 2.4e-16 60.2 4.9 6e-16 58.9 4.9 1.7 1 0 0 1 1 1 1 RecQ zinc-binding ResIII PF04851.15 CCF52453.1 - 5.6e-06 26.5 0.0 1.9e-05 24.7 0.0 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Voldacs PF03517.13 CCF52453.1 - 0.0098 16.0 0.5 0.037 14.1 0.5 2.1 1 0 0 1 1 1 1 Regulator of volume decrease after cellular swelling HRDC PF00570.23 CCF52453.1 - 0.011 15.7 0.0 0.027 14.5 0.0 1.6 1 0 0 1 1 1 0 HRDC domain UME PF08064.13 CCF52453.1 - 0.18 11.8 0.0 0.54 10.2 0.0 1.8 1 0 0 1 1 1 0 UME (NUC010) domain AAA_11 PF13086.6 CCF52454.1 - 0.31 10.8 10.2 0.62 9.8 10.2 1.4 1 0 0 1 1 1 0 AAA domain Fib_alpha PF08702.10 CCF52454.1 - 0.56 10.4 6.0 1.1 9.4 6.0 1.4 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family FAM76 PF16046.5 CCF52454.1 - 3 7.1 6.7 5.8 6.2 6.7 1.4 1 0 0 1 1 1 0 FAM76 protein DUF1674 PF07896.12 CCF52455.1 - 1.8e-17 63.5 5.3 1.8e-17 63.5 5.3 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF1674) MFS_1 PF07690.16 CCF52456.1 - 3.6e-09 36.0 23.1 3.6e-09 36.0 23.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Mis14 PF08641.12 CCF52457.1 - 2.4e-07 31.1 6.8 2.4e-07 31.1 6.8 1.9 2 0 0 2 2 2 1 Kinetochore protein Mis14 like DUF1338 PF07063.13 CCF52457.1 - 0.017 14.3 2.9 0.02 14.1 2.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1338) DUF2935 PF11155.8 CCF52457.1 - 0.14 12.4 1.1 2.4 8.5 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF2935) DUF2285 PF10074.9 CCF52457.1 - 0.17 12.6 8.8 2.3 8.9 6.1 2.5 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2285) Ribosomal_L27e PF01777.18 CCF52457.1 - 0.74 10.2 4.8 0.39 11.1 1.1 2.2 2 0 0 2 2 2 0 Ribosomal L27e protein family FlaG PF03646.15 CCF52457.1 - 5.7 7.2 9.5 1.4 9.1 0.1 3.0 3 1 0 3 3 3 0 FlaG protein DUF4576 PF15144.6 CCF52458.1 - 0.035 14.0 0.1 0.21 11.5 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4576) DUF3510 PF12022.8 CCF52458.1 - 0.22 11.9 0.1 0.22 11.9 0.1 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF3510) CALM_bind PF16025.5 CCF52458.1 - 2.9 8.4 10.3 8.5 6.9 3.1 4.2 4 1 0 4 4 4 0 Calcium-dependent calmodulin binding DUF2315 PF10231.9 CCF52459.1 - 7.6e-20 71.2 4.2 1.1e-13 51.3 3.5 2.9 2 1 0 2 2 2 2 Apoptogenic protein 1 CSTF2_hinge PF14327.6 CCF52460.1 - 1.2e-32 112.2 2.0 1.2e-32 112.2 2.0 2.1 2 1 0 2 2 2 1 Hinge domain of cleavage stimulation factor subunit 2 RRM_1 PF00076.22 CCF52460.1 - 1.6e-23 82.2 0.1 2.7e-23 81.6 0.1 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CSTF_C PF14304.6 CCF52460.1 - 2.2e-14 52.7 5.3 2.2e-14 52.7 5.3 2.7 3 0 0 3 3 3 1 Transcription termination and cleavage factor C-terminal RRM_7 PF16367.5 CCF52460.1 - 0.00039 20.5 0.1 0.00081 19.5 0.1 1.5 1 1 0 1 1 1 1 RNA recognition motif Spo7_2_N PF15407.6 CCF52460.1 - 0.17 11.6 0.0 0.27 10.9 0.0 1.3 1 0 0 1 1 1 0 Sporulation protein family 7 RRM_occluded PF16842.5 CCF52460.1 - 0.22 11.4 0.0 0.56 10.1 0.0 1.7 1 0 0 1 1 1 0 Occluded RNA-recognition motif PHM7_cyt PF14703.6 CCF52460.1 - 0.22 11.7 0.0 11 6.2 0.0 2.2 1 1 1 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter RhoGEF PF00621.20 CCF52461.1 - 1.5e-12 48.1 0.0 6.9e-08 32.9 0.1 2.4 2 0 0 2 2 2 2 RhoGEF domain Prefoldin_2 PF01920.20 CCF52462.1 - 2.6e-18 65.9 7.8 4.1e-18 65.3 7.8 1.3 1 0 0 1 1 1 1 Prefoldin subunit DUF2408 PF10303.9 CCF52462.1 - 0.044 14.3 5.7 0.059 13.9 5.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2408) WSD PF15613.6 CCF52462.1 - 0.051 14.0 3.1 1.3 9.5 0.2 2.1 2 0 0 2 2 2 0 Williams-Beuren syndrome DDT (WSD), D-TOX E motif XhlA PF10779.9 CCF52462.1 - 0.17 12.1 0.6 0.17 12.1 0.6 2.1 2 1 0 2 2 2 0 Haemolysin XhlA NPV_P10 PF05531.12 CCF52462.1 - 0.17 12.4 6.8 0.65 10.5 0.9 2.4 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Sipho_Gp157 PF05565.11 CCF52462.1 - 0.27 11.2 7.9 1.4 8.9 1.7 2.0 1 1 1 2 2 2 0 Siphovirus Gp157 Fib_alpha PF08702.10 CCF52462.1 - 0.38 10.9 6.7 3.6 7.8 3.4 2.1 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family EMP24_GP25L PF01105.24 CCF52462.1 - 0.45 10.4 4.7 1.5 8.7 0.4 2.0 2 0 0 2 2 2 0 emp24/gp25L/p24 family/GOLD DUF5320 PF17253.2 CCF52462.1 - 0.56 11.3 0.1 0.56 11.3 0.1 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5320) DUF4349 PF14257.6 CCF52462.1 - 1.3 8.4 7.7 6.3 6.2 1.3 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4349) DUF5595 PF18077.1 CCF52462.1 - 2.1 8.5 5.0 0.58 10.3 0.8 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF5595) Tropomyosin_1 PF12718.7 CCF52462.1 - 2.3 8.3 13.6 0.2 11.8 5.3 2.0 2 0 0 2 2 2 0 Tropomyosin like Baculo_PEP_C PF04513.12 CCF52462.1 - 2.9 7.9 9.4 34 4.5 9.4 2.1 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus DivIC PF04977.15 CCF52462.1 - 4.6 7.1 14.7 4.4 7.1 2.1 2.4 2 1 0 2 2 2 0 Septum formation initiator SlyX PF04102.12 CCF52462.1 - 8.2 7.1 14.6 1.7 9.3 2.6 2.5 2 1 0 2 2 2 0 SlyX DUF4140 PF13600.6 CCF52462.1 - 8.4 6.9 9.9 7.6 7.0 2.3 2.3 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) Chalcone_2 PF16035.5 CCF52463.1 - 4.6e-36 124.5 1.3 6.3e-34 117.6 1.3 2.4 1 1 0 1 1 1 1 Chalcone isomerase like Chalcone_3 PF16036.5 CCF52463.1 - 8.2e-06 26.0 0.1 0.0025 18.0 0.1 2.4 1 1 1 2 2 2 2 Chalcone isomerase-like RcbX PF02341.15 CCF52463.1 - 0.02 15.2 0.0 0.035 14.4 0.0 1.3 1 0 0 1 1 1 0 RbcX protein Acetyltransf_1 PF00583.25 CCF52464.1 - 9.7e-15 54.8 0.0 1.2e-14 54.5 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CCF52464.1 - 2.1e-10 40.6 0.0 2.6e-10 40.3 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CCF52464.1 - 4.8e-10 39.7 0.1 6.7e-10 39.3 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 CCF52464.1 - 0.0034 17.5 0.0 0.0043 17.2 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CCF52464.1 - 0.0055 16.6 0.0 0.009 16.0 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_CG PF14542.6 CCF52464.1 - 0.0091 16.1 0.0 0.018 15.2 0.0 1.4 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_9 PF13527.7 CCF52464.1 - 0.014 15.5 0.0 0.019 15.1 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain V-SNARE_C PF12352.8 CCF52466.1 - 0.038 14.3 3.5 0.83 10.0 0.3 2.6 2 0 0 2 2 2 0 Snare region anchored in the vesicle membrane C-terminus Neur_chan_memb PF02932.16 CCF52466.1 - 0.46 10.5 5.4 0.86 9.6 5.4 1.5 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region ADH_N PF08240.12 CCF52467.1 - 1.3e-15 57.2 0.5 2.1e-15 56.5 0.5 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CCF52467.1 - 1.2e-05 25.2 0.0 2.3e-05 24.4 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 CCF52467.1 - 0.073 12.4 0.0 0.11 11.9 0.0 1.2 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NADH_4Fe-4S PF10589.9 CCF52467.1 - 0.099 12.7 1.0 0.2 11.7 1.0 1.5 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region TMEM154 PF15102.6 CCF52468.1 - 0.0063 16.4 0.8 0.03 14.2 0.0 2.4 2 0 0 2 2 2 1 TMEM154 protein family FEZ PF07763.13 CCF52469.1 - 0.92 9.2 4.9 0.17 11.6 0.4 2.1 2 0 0 2 2 2 0 FEZ-like protein DUF1741 PF08427.10 CCF52470.1 - 9.9e-24 84.3 0.5 1.8e-23 83.4 0.5 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1741) DDE_Tnp_1_assoc PF13808.6 CCF52470.1 - 0.039 14.0 0.2 0.51 10.4 0.0 2.9 2 1 1 3 3 3 0 DDE_Tnp_1-associated SEP PF08059.13 CCF52471.1 - 8.1e-24 84.0 0.0 1.9e-23 82.8 0.0 1.7 1 0 0 1 1 1 1 SEP domain UBX PF00789.20 CCF52471.1 - 8.9e-17 61.1 0.1 1.4e-16 60.4 0.1 1.3 1 0 0 1 1 1 1 UBX domain UBA_4 PF14555.6 CCF52471.1 - 6.9e-16 57.8 0.2 1.2e-15 57.0 0.2 1.5 1 0 0 1 1 1 1 UBA-like domain DarA_N PF18788.1 CCF52471.1 - 0.21 11.7 0.4 0.63 10.1 0.1 1.9 1 1 1 2 2 2 0 Defence against restriction A N-terminal Tim17 PF02466.19 CCF52472.1 - 7.3e-09 36.0 9.8 7.3e-09 36.0 9.8 1.6 2 0 0 2 2 2 1 Tim17/Tim22/Tim23/Pmp24 family Phage_holin_3_3 PF16083.5 CCF52472.1 - 0.015 15.4 8.4 0.16 12.1 5.6 2.3 2 0 0 2 2 2 0 LydA holin phage, holin superfamily III 5TM-5TMR_LYT PF07694.12 CCF52472.1 - 0.7 9.4 5.9 0.86 9.1 5.2 1.5 1 1 1 2 2 2 0 5TMR of 5TMR-LYT tRNA_bind PF01588.20 CCF52473.1 - 3.4e-27 94.4 0.0 7.9e-27 93.2 0.0 1.7 1 0 0 1 1 1 1 Putative tRNA binding domain GST_C PF00043.25 CCF52473.1 - 5.4e-05 23.3 2.1 0.00026 21.1 0.0 2.5 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 CCF52473.1 - 0.00075 19.7 0.0 0.00075 19.7 0.0 2.2 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_6 PF17171.4 CCF52473.1 - 0.017 14.9 0.0 0.032 14.0 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 CCF52473.1 - 0.037 14.1 0.3 0.12 12.4 0.3 2.0 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain DUF3464 PF11947.8 CCF52473.1 - 4.1 7.1 4.9 8.3 6.1 4.9 1.6 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 adh_short PF00106.25 CCF52474.1 - 2.3e-05 23.9 0.0 0.01 15.3 0.0 3.3 3 1 0 3 3 3 2 short chain dehydrogenase DUF3425 PF11905.8 CCF52475.1 - 1.7e-37 128.1 0.4 3.1e-37 127.3 0.4 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3425) bZIP_1 PF00170.21 CCF52475.1 - 0.00014 21.8 7.8 0.00033 20.7 7.8 1.5 1 0 0 1 1 1 1 bZIP transcription factor EPL1 PF10513.9 CCF52475.1 - 0.02 15.3 7.2 0.034 14.5 0.4 3.0 3 0 0 3 3 3 0 Enhancer of polycomb-like Kei1 PF08552.11 CCF52475.1 - 0.06 13.2 7.8 0.56 10.1 0.1 2.7 2 0 0 2 2 2 0 Inositolphosphorylceramide synthase subunit Kei1 SID-1_RNA_chan PF13965.6 CCF52475.1 - 0.29 9.5 0.2 0.53 8.6 0.2 1.4 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DUF2151 PF10221.9 CCF52475.1 - 1.9 7.0 7.2 0.32 9.6 0.5 2.1 2 0 0 2 2 2 0 Cell cycle and development regulator U1snRNP70_N PF12220.8 CCF52475.1 - 7.3 7.3 13.8 4.6 8.0 4.8 3.3 3 0 0 3 3 3 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal UDPGP PF01704.18 CCF52476.1 - 1e-47 162.7 0.0 1.3e-47 162.4 0.0 1.0 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase NTP_transf_3 PF12804.7 CCF52476.1 - 0.13 12.6 0.1 0.97 9.8 0.0 2.2 2 0 0 2 2 2 0 MobA-like NTP transferase domain Ribosomal_L4 PF00573.22 CCF52477.1 - 3e-41 141.2 0.5 4.6e-41 140.6 0.5 1.3 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family Ribos_L4_asso_C PF14374.6 CCF52477.1 - 5e-30 103.4 2.7 2.7e-29 101.0 0.3 2.4 2 0 0 2 2 2 1 60S ribosomal protein L4 C-terminal domain RCDG1 PF15725.5 CCF52477.1 - 0.019 15.4 0.7 0.095 13.1 0.1 2.1 2 0 0 2 2 2 0 Renal cancer differentiation gene 1 protein Nic96 PF04097.14 CCF52477.1 - 0.055 11.9 0.1 0.08 11.4 0.1 1.1 1 0 0 1 1 1 0 Nup93/Nic96 Ribosomal_S14 PF00253.21 CCF52478.1 - 1.3e-16 60.1 3.9 1.4e-16 60.0 3.9 1.0 1 0 0 1 1 1 1 Ribosomal protein S14p/S29e Aconitase PF00330.20 CCF52479.1 - 3.9e-153 510.7 0.0 5.1e-153 510.4 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 CCF52479.1 - 1.6e-42 144.9 0.1 3.9e-42 143.7 0.0 1.7 2 0 0 2 2 2 1 Aconitase C-terminal domain DUF521 PF04412.13 CCF52479.1 - 0.057 12.1 0.0 0.11 11.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF521) MFS_1 PF07690.16 CCF52481.1 - 3.6e-27 95.2 42.7 4.9e-23 81.6 20.5 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF52481.1 - 2e-20 73.1 19.4 5.1e-19 68.5 19.0 2.1 1 1 0 1 1 1 1 Sugar (and other) transporter RhoGAP PF00620.27 CCF52484.1 - 2.6e-36 124.7 0.0 3.9e-36 124.2 0.0 1.2 1 0 0 1 1 1 1 RhoGAP domain DUF1708 PF08101.11 CCF52484.1 - 0.019 14.1 0.0 0.036 13.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1708) DUF2057 PF09829.9 CCF52484.1 - 10 6.3 10.2 5.9 7.0 1.8 3.1 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2057) RNA_pol_Rbc25 PF08292.12 CCF52485.1 - 1e-40 139.0 0.0 1.4e-40 138.5 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase III subunit Rpc25 SHS2_Rpb7-N PF03876.17 CCF52485.1 - 2.6e-18 66.1 0.0 4.8e-18 65.3 0.0 1.5 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 Bac_surface_Ag PF01103.23 CCF52486.1 - 5.8e-34 118.0 0.1 4.6e-20 72.4 0.0 2.1 2 0 0 2 2 2 2 Surface antigen Herpes_DNAp_acc PF04929.12 CCF52486.1 - 4.3 6.2 8.3 8 5.3 8.3 1.4 1 0 0 1 1 1 0 Herpes DNA replication accessory factor RPN1_RPN2_N PF17781.1 CCF52487.1 - 7e-124 413.2 1.3 1.2e-123 412.5 1.3 1.4 1 0 0 1 1 1 1 RPN1/RPN2 N-terminal domain RPN1_C PF18051.1 CCF52487.1 - 1.2e-27 95.7 0.1 2.3e-27 94.8 0.1 1.5 1 0 0 1 1 1 1 26S proteasome non-ATPase regulatory subunit RPN1 C-terminal PC_rep PF01851.22 CCF52487.1 - 6e-20 70.6 13.9 0.00014 22.1 0.2 8.0 8 0 0 8 8 8 5 Proteasome/cyclosome repeat HEAT_2 PF13646.6 CCF52487.1 - 7.5e-05 23.0 0.6 0.25 11.7 0.1 4.0 3 1 1 4 4 4 3 HEAT repeats Corazonin PF17308.2 CCF52487.1 - 0.16 12.3 0.5 0.53 10.6 0.5 1.8 1 0 0 1 1 1 0 Pro-corazonin Cation_efflux PF01545.21 CCF52488.1 - 2.3e-48 164.6 19.1 5e-48 163.5 19.1 1.6 1 1 0 1 1 1 1 Cation efflux family Dynamin_N PF00350.23 CCF52489.1 - 1.2e-42 145.9 0.0 2.1e-42 145.0 0.0 1.5 1 0 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.23 CCF52489.1 - 9.2e-05 22.5 0.0 0.00045 20.3 0.0 2.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_M PF01031.20 CCF52489.1 - 0.00021 20.6 0.2 0.011 15.0 0.2 3.1 2 1 0 2 2 2 1 Dynamin central region FtsK_SpoIIIE PF01580.18 CCF52489.1 - 0.1 11.9 0.0 0.23 10.8 0.0 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_21 PF13304.6 CCF52489.1 - 0.14 11.9 0.0 0.32 10.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system dUTPase PF00692.19 CCF52490.1 - 7.1e-44 148.6 0.0 9.8e-44 148.2 0.0 1.2 1 0 0 1 1 1 1 dUTPase Vps8 PF12816.7 CCF52491.1 - 8.6e-71 237.5 0.0 5.7e-70 234.9 0.0 2.2 2 0 0 2 2 2 1 Golgi CORVET complex core vacuolar protein 8 UCH PF00443.29 CCF52493.1 - 9.8e-40 136.7 0.0 1.9e-39 135.7 0.0 1.5 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase RPT PF13446.6 CCF52493.1 - 6.6e-22 77.2 2.5 8.2e-17 60.9 0.9 3.6 3 0 0 3 3 3 3 A repeated domain in UCH-protein UCH_1 PF13423.6 CCF52493.1 - 3.1e-06 27.0 0.2 0.042 13.4 0.0 2.7 3 0 0 3 3 3 2 Ubiquitin carboxyl-terminal hydrolase DUF3158 PF11358.8 CCF52493.1 - 0.13 11.9 0.0 0.34 10.6 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3158) Pox_A_type_inc PF04508.12 CCF52493.1 - 0.2 11.6 0.3 0.66 9.9 0.3 2.0 1 0 0 1 1 1 0 Viral A-type inclusion protein repeat BAR PF03114.18 CCF52493.1 - 0.57 9.8 4.1 0.22 11.1 0.6 2.0 2 0 0 2 2 2 0 BAR domain Csm1_N PF18504.1 CCF52493.1 - 0.61 10.5 2.3 1.8 8.9 0.1 2.6 2 1 1 3 3 3 0 Csm1 N-terminal domain Adaptin_N PF01602.20 CCF52494.1 - 6.8e-06 24.9 0.1 0.0033 16.0 0.0 4.3 4 1 0 4 4 4 1 Adaptin N terminal region Cnd1 PF12717.7 CCF52494.1 - 0.0013 18.8 0.4 43 4.1 0.0 6.3 5 1 1 6 6 6 0 non-SMC mitotic condensation complex subunit 1 Arm PF00514.23 CCF52494.1 - 0.0053 16.8 6.5 0.065 13.3 0.1 4.2 4 0 0 4 4 4 1 Armadillo/beta-catenin-like repeat Cnd3 PF12719.7 CCF52494.1 - 0.014 14.6 0.0 10 5.2 0.0 3.9 3 0 0 3 3 3 0 Nuclear condensing complex subunits, C-term domain HEAT_EZ PF13513.6 CCF52494.1 - 0.023 15.2 26.1 0.074 13.6 0.0 7.1 6 1 1 7 7 7 0 HEAT-like repeat HEAT PF02985.22 CCF52494.1 - 0.062 13.6 25.2 0.57 10.6 0.1 8.5 8 0 0 8 8 8 0 HEAT repeat Vac14_Fab1_bd PF12755.7 CCF52494.1 - 0.13 12.9 0.0 31 5.3 0.0 3.8 3 0 0 3 3 3 0 Vacuolar 14 Fab1-binding region HEAT_2 PF13646.6 CCF52494.1 - 0.2 12.0 20.6 9.3 6.7 1.5 8.4 7 1 1 8 8 8 0 HEAT repeats THUMP PF02926.17 CCF52495.1 - 2.7e-11 43.8 0.2 6.9e-11 42.4 0.0 1.8 2 0 0 2 2 2 1 THUMP domain DGCR6 PF07324.11 CCF52496.1 - 0.00017 21.3 3.5 0.00058 19.5 3.4 1.8 1 1 1 2 2 2 1 DiGeorge syndrome critical region 6 (DGCR6) protein Aminotran_3 PF00202.21 CCF52497.1 - 1.3e-37 129.4 0.0 1.2e-15 57.1 0.0 3.1 3 0 0 3 3 3 3 Aminotransferase class-III AAA_26 PF13500.6 CCF52497.1 - 1.5e-07 31.5 0.0 5.6e-06 26.3 0.0 2.6 2 1 0 2 2 2 1 AAA domain Vps39_1 PF10366.9 CCF52499.1 - 6.8e-31 106.7 0.1 3.8e-30 104.4 0.0 2.4 2 0 0 2 2 2 1 Vacuolar sorting protein 39 domain 1 Vps39_2 PF10367.9 CCF52499.1 - 2.3e-24 85.9 0.7 4.8e-24 84.9 0.2 1.8 2 0 0 2 2 2 1 Vacuolar sorting protein 39 domain 2 CNH PF00780.22 CCF52499.1 - 1.5e-11 44.4 0.0 0.00035 20.3 0.0 3.4 3 0 0 3 3 3 2 CNH domain Clathrin PF00637.20 CCF52499.1 - 2.8e-08 33.8 0.4 0.0014 18.6 0.0 3.3 3 1 0 3 3 3 2 Region in Clathrin and VPS TPR_12 PF13424.6 CCF52499.1 - 0.11 12.8 3.5 3.1 8.1 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.6 CCF52499.1 - 0.27 11.8 2.1 1.2 9.7 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat Dus PF01207.17 CCF52500.1 - 1e-39 136.5 0.1 1.6e-39 135.8 0.1 1.3 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) Pyridox_oxase_2 PF12766.7 CCF52500.1 - 1.1e-24 86.9 0.0 2.2e-24 86.0 0.0 1.5 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Peptidase_S58 PF03576.14 CCF52500.1 - 0.017 14.7 0.0 0.032 13.8 0.0 1.4 1 0 0 1 1 1 0 Peptidase family S58 His_Phos_1 PF00300.22 CCF52501.1 - 1e-22 80.8 0.0 1.4e-22 80.4 0.0 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) AARP2CN PF08142.12 CCF52502.1 - 0.1 12.7 0.0 0.17 12.0 0.0 1.4 1 0 0 1 1 1 0 AARP2CN (NUC121) domain NIR_SIR PF01077.22 CCF52503.1 - 9.1e-44 148.8 0.0 1.2e-40 138.6 0.0 2.4 2 0 0 2 2 2 2 Nitrite and sulphite reductase 4Fe-4S domain NIR_SIR_ferr PF03460.17 CCF52503.1 - 1.6e-28 98.3 0.0 2e-15 56.4 0.0 2.7 2 0 0 2 2 2 2 Nitrite/Sulfite reductase ferredoxin-like half domain Flavodoxin_1 PF00258.25 CCF52503.1 - 5e-28 98.1 0.0 1.1e-27 97.1 0.0 1.6 1 0 0 1 1 1 1 Flavodoxin POR_N PF01855.19 CCF52503.1 - 7.2e-09 35.7 0.5 1.5e-08 34.7 0.1 1.7 2 0 0 2 2 2 1 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg HAD_2 PF13419.6 CCF52504.1 - 3.1e-20 73.0 0.0 7.4e-20 71.8 0.0 1.6 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 CCF52504.1 - 6.8e-15 55.9 0.0 6.5e-13 49.5 0.0 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 CCF52504.1 - 1.6e-06 28.1 0.0 2.8e-06 27.3 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like HAD PF12710.7 CCF52504.1 - 0.016 15.6 0.0 0.031 14.7 0.0 1.5 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase P22_Tail-4 PF11650.8 CCF52504.1 - 0.077 12.9 0.1 0.15 12.0 0.1 1.4 1 0 0 1 1 1 0 P22 tail accessory factor Ribosomal_L13e PF01294.18 CCF52505.1 - 7.4e-74 247.5 8.8 1.1e-73 246.9 8.8 1.2 1 0 0 1 1 1 1 Ribosomal protein L13e Herpes_US12 PF05363.12 CCF52505.1 - 0.53 11.0 3.2 4.3 8.1 0.2 2.3 2 0 0 2 2 2 0 Herpesvirus US12 family DUF1279 PF06916.13 CCF52508.1 - 2.7e-21 75.9 0.0 6e-21 74.8 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1279) Amnionless PF14828.6 CCF52509.1 - 0.01 14.7 0.1 0.054 12.3 0.0 1.8 1 1 1 2 2 2 1 Amnionless Utp14 PF04615.13 CCF52509.1 - 0.29 9.7 8.1 0.39 9.2 8.1 1.1 1 0 0 1 1 1 0 Utp14 protein Plasmodium_Vir PF05795.11 CCF52509.1 - 6.8 6.0 4.8 13 5.1 5.0 1.4 1 1 0 1 1 1 0 Plasmodium vivax Vir protein TRAM_LAG1_CLN8 PF03798.16 CCF52510.1 - 9.9e-32 110.3 27.7 9.9e-32 110.3 27.7 2.6 3 0 0 3 3 3 1 TLC domain TRAM1 PF08390.11 CCF52510.1 - 1.7e-24 85.2 0.1 1.7e-24 85.2 0.1 2.3 2 0 0 2 2 2 1 TRAM1-like protein Podoplanin PF05808.11 CCF52510.1 - 3 7.9 4.7 5.5 7.1 4.7 1.4 1 0 0 1 1 1 0 Podoplanin SLD5_C PF16922.5 CCF52511.1 - 1.8e-13 50.4 0.0 2.9e-13 49.8 0.0 1.3 1 0 0 1 1 1 1 DNA replication complex GINS protein SLD5 C-terminus Sec16 PF12932.7 CCF52511.1 - 0.21 12.2 0.5 18 6.0 0.1 2.3 2 0 0 2 2 2 0 Vesicle coat trafficking protein Sec16 mid-region Frag1 PF10277.9 CCF52513.1 - 1.3e-31 109.9 6.4 3.9e-31 108.3 6.4 1.9 1 0 0 1 1 1 1 Frag1/DRAM/Sfk1 family PUF PF00806.19 CCF52515.1 - 4.9e-14 51.1 0.0 3.8e-05 23.1 0.0 6.5 7 0 0 7 7 7 3 Pumilio-family RNA binding repeat CD52 PF15116.6 CCF52516.1 - 0.52 10.4 3.1 0.88 9.6 0.0 2.7 2 0 0 2 2 2 0 CAMPATH-1 antigen ASH PF15780.5 CCF52518.1 - 3.9e-17 62.3 0.0 0.035 14.3 0.0 7.1 8 1 1 9 9 9 4 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin PapD-like PF14874.6 CCF52518.1 - 9.5e-09 35.3 0.1 0.25 11.5 0.0 5.2 5 0 0 5 5 5 3 Flagellar-associated PapD-like TMEM131_like PF12371.8 CCF52518.1 - 2.3e-05 24.6 0.2 13 6.1 0.0 6.3 5 1 2 7 7 7 2 Transmembrane protein 131-like DUF1573 PF07610.11 CCF52518.1 - 0.033 14.2 0.1 81 3.3 0.0 4.7 5 0 0 5 5 5 0 Protein of unknown function (DUF1573) DUF1090 PF06476.12 CCF52518.1 - 1.3 9.2 4.7 0.46 10.6 1.7 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1090) Ctf8 PF09696.10 CCF52519.1 - 5.1e-15 56.0 7.1 3.7e-06 27.3 0.4 3.2 2 1 1 3 3 3 3 Ctf8 Urb2 PF10441.9 CCF52520.1 - 3.3e-43 148.0 0.9 3.3e-43 148.0 0.9 4.3 3 0 0 3 3 3 3 Urb2/Npa2 family Ribosomal_L36 PF00444.18 CCF52521.1 - 4.2e-22 78.0 8.0 6.9e-22 77.4 8.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L36 DUF3169 PF11368.8 CCF52522.1 - 0.75 9.3 2.6 3 7.3 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3169) Atg14 PF10186.9 CCF52524.1 - 5.8e-13 48.6 0.8 1.5e-12 47.2 0.8 1.7 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 VPS38 PF17649.1 CCF52524.1 - 0.026 13.4 0.2 0.18 10.6 0.0 2.1 2 0 0 2 2 2 0 Vacuolar protein sorting 38 bZIP_Maf PF03131.17 CCF52524.1 - 1.9 9.1 12.0 0.54 10.8 7.2 2.6 1 1 1 2 2 2 0 bZIP Maf transcription factor Seryl_tRNA_N PF02403.22 CCF52524.1 - 2.6 8.3 5.6 1.9 8.8 2.2 2.3 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain HIP1_clath_bdg PF16515.5 CCF52524.1 - 9.2 6.9 16.0 0.57 10.8 7.9 2.6 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 NTP_transferase PF00483.23 CCF52525.1 - 5.9e-45 153.8 0.0 9.2e-45 153.1 0.0 1.2 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.7 CCF52525.1 - 6.1e-07 29.9 0.6 6.1e-07 29.9 0.6 1.7 2 0 0 2 2 2 1 MobA-like NTP transferase domain MannoseP_isomer PF01050.18 CCF52525.1 - 1.7e-05 24.7 0.1 3e-05 23.9 0.1 1.3 1 0 0 1 1 1 1 Mannose-6-phosphate isomerase IspD PF01128.19 CCF52525.1 - 0.038 13.7 0.0 0.075 12.8 0.0 1.5 1 0 0 1 1 1 0 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase PAPS_reduct PF01507.19 CCF52527.1 - 7.9e-37 127.0 0.0 1.2e-36 126.4 0.0 1.3 1 0 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family Amidohydro_1 PF01979.20 CCF52528.1 - 4.6e-58 197.2 0.0 1.5e-27 96.8 0.0 3.1 3 0 0 3 3 3 3 Amidohydrolase family Amidohydro_3 PF07969.11 CCF52528.1 - 8.8e-06 25.4 0.0 0.14 11.6 0.0 3.2 3 0 0 3 3 3 3 Amidohydrolase family DUF3395 PF11875.8 CCF52529.1 - 4.9e-43 146.7 0.2 9.8e-43 145.8 0.0 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF3395) DnaJ PF00226.31 CCF52529.1 - 1.3e-22 79.7 0.6 2.5e-22 78.8 0.6 1.5 1 0 0 1 1 1 1 DnaJ domain Apt1 PF10351.9 CCF52529.1 - 5.4 5.8 9.8 7.9 5.2 9.8 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain Hamartin PF04388.12 CCF52529.1 - 5.9 5.4 9.1 9 4.8 9.1 1.2 1 0 0 1 1 1 0 Hamartin protein Med5 PF08689.10 CCF52530.1 - 3e-24 85.0 0.1 2.8e-23 81.8 0.0 2.0 2 0 0 2 2 2 1 Mediator complex subunit Med5 Phage-MuB_C PF09077.11 CCF52530.1 - 0.06 13.2 0.8 0.27 11.2 0.4 2.3 2 0 0 2 2 2 0 Mu B transposition protein, C terminal DUF2353 PF09789.9 CCF52530.1 - 0.11 11.9 0.6 0.21 10.9 0.6 1.3 1 0 0 1 1 1 0 Uncharacterized coiled-coil protein (DUF2353) Aa_trans PF01490.18 CCF52531.1 - 2.2e-80 270.4 32.2 2.7e-80 270.1 32.2 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein UCR_TM PF02921.14 CCF52531.1 - 0.036 14.5 1.7 0.46 11.0 0.2 3.4 3 0 0 3 3 3 0 Ubiquinol cytochrome reductase transmembrane region PTPRCAP PF15713.5 CCF52531.1 - 0.055 13.8 0.6 0.055 13.8 0.6 1.7 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated YpmT PF17431.2 CCF52531.1 - 0.56 10.3 5.9 0.22 11.6 0.5 2.9 2 0 0 2 2 2 0 Uncharacterized YmpT-like MASE2 PF05230.11 CCF52531.1 - 1.8 8.7 7.5 0.15 12.1 0.6 2.6 2 0 0 2 2 2 0 MASE2 domain PHO4 PF01384.20 CCF52531.1 - 3.8 6.5 20.1 46 2.9 19.9 2.2 1 1 0 1 1 1 0 Phosphate transporter family Redoxin PF08534.10 CCF52532.1 - 3.7e-34 117.5 0.0 4.1e-34 117.4 0.0 1.0 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 CCF52532.1 - 3.5e-07 30.2 0.0 3.7e-07 30.1 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Yippee-Mis18 PF03226.14 CCF52533.1 - 1.3e-23 83.2 0.0 2.2e-23 82.5 0.0 1.3 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly FoP_duplication PF13865.6 CCF52533.1 - 3.8 8.1 9.5 14 6.4 9.5 1.9 1 0 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 DCP1 PF06058.13 CCF52534.1 - 8.7e-33 112.7 0.0 1.2e-32 112.3 0.0 1.2 1 0 0 1 1 1 1 Dcp1-like decapping family mRNA_decap_C PF16741.5 CCF52534.1 - 1.7e-05 24.0 0.0 2.7e-05 23.4 0.0 1.3 1 0 0 1 1 1 1 mRNA-decapping enzyme C-terminus RSB_motif PF16294.5 CCF52534.1 - 0.13 12.5 6.1 0.42 10.9 0.1 3.1 2 1 1 3 3 3 0 RNSP1-SAP18 binding (RSB) motif HLH PF00010.26 CCF52535.1 - 7.4e-18 64.3 0.0 2.3e-17 62.7 0.0 1.9 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain TIMELESS PF04821.14 CCF52536.1 - 9.3e-75 251.4 0.0 2.2e-74 250.2 0.0 1.7 1 0 0 1 1 1 1 Timeless protein NUDIX PF00293.28 CCF52537.1 - 6.5e-11 42.4 0.0 1.5e-10 41.2 0.0 1.5 1 0 0 1 1 1 1 NUDIX domain RPAP2_Rtr1 PF04181.13 CCF52538.1 - 2.1e-18 66.4 0.0 4.3e-18 65.4 0.0 1.5 1 0 0 1 1 1 1 Rtr1/RPAP2 family DAP3 PF10236.9 CCF52538.1 - 0.17 11.1 0.0 0.24 10.6 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 BTB PF00651.31 CCF52539.1 - 1.4e-09 38.2 0.4 0.00021 21.5 0.1 2.9 3 0 0 3 3 3 2 BTB/POZ domain SSF PF00474.17 CCF52540.1 - 1.3e-14 53.9 19.5 1.3e-14 53.9 19.5 1.9 2 1 0 2 2 2 1 Sodium:solute symporter family TMEM107 PF14995.6 CCF52540.1 - 0.021 15.3 2.9 0.1 13.0 0.1 3.1 2 1 0 3 3 3 0 Transmembrane protein Arrestin_N PF00339.29 CCF52541.1 - 2.6e-08 34.1 0.0 7.5e-08 32.5 0.0 1.8 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 CCF52541.1 - 0.00059 20.3 0.0 0.077 13.4 0.0 2.6 2 0 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain Spo0M PF07070.11 CCF52541.1 - 0.012 15.2 0.0 0.027 14.0 0.0 1.5 1 0 0 1 1 1 0 SpoOM protein Borrelia_P83 PF05262.11 CCF52541.1 - 0.023 13.2 22.5 0.0067 15.0 18.0 2.1 2 0 0 2 2 2 0 Borrelia P83/100 protein DUF5401 PF17380.2 CCF52541.1 - 0.91 7.5 40.6 1.8 6.5 40.6 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5401) DUF572 PF04502.13 CCF52541.1 - 1.8 8.1 38.7 0.24 11.0 4.9 2.9 3 0 0 3 3 3 0 Family of unknown function (DUF572) HABP4_PAI-RBP1 PF04774.15 CCF52542.1 - 2e-11 44.8 8.4 2e-11 44.8 8.4 3.1 2 2 1 3 3 3 1 Hyaluronan / mRNA binding family Stm1_N PF09598.10 CCF52542.1 - 0.0088 16.9 14.8 0.0088 16.9 14.8 5.2 2 2 0 2 2 2 1 Stm1 ECM1 PF05782.11 CCF52542.1 - 0.079 11.9 0.8 0.1 11.5 0.8 1.2 1 0 0 1 1 1 0 Extracellular matrix protein 1 (ECM1) Ribosomal_S3_C PF00189.20 CCF52543.1 - 2.2e-24 85.8 0.2 9.5e-24 83.7 0.5 1.8 2 0 0 2 2 2 1 Ribosomal protein S3, C-terminal domain KH_2 PF07650.17 CCF52543.1 - 7e-13 48.2 0.0 1.2e-12 47.4 0.0 1.4 1 0 0 1 1 1 1 KH domain UN_NPL4 PF11543.8 CCF52543.1 - 0.031 14.7 0.0 0.06 13.8 0.0 1.5 1 0 0 1 1 1 0 Nuclear pore localisation protein NPL4 Coilin_N PF15862.5 CCF52543.1 - 0.2 11.5 0.0 0.3 10.9 0.0 1.3 1 0 0 1 1 1 0 Coilin N-terminus Memo PF01875.17 CCF52544.1 - 5.7e-76 255.2 0.0 1.3e-75 254.1 0.0 1.5 1 1 0 1 1 1 1 Memo-like protein SWIB PF02201.18 CCF52545.1 - 4.9e-22 77.6 0.0 8.2e-22 76.9 0.0 1.4 1 0 0 1 1 1 1 SWIB/MDM2 domain ACBP PF00887.19 CCF52547.1 - 3.6e-31 107.2 0.4 5.4e-31 106.7 0.4 1.3 1 0 0 1 1 1 1 Acyl CoA binding protein DUF3961 PF13106.6 CCF52547.1 - 0.16 11.6 0.6 0.43 10.3 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3961) HEAT PF02985.22 CCF52548.1 - 3.2e-39 129.6 19.7 0.0038 17.4 0.0 13.7 14 0 0 14 14 14 10 HEAT repeat HEAT_2 PF13646.6 CCF52548.1 - 2.3e-35 120.8 9.2 8e-12 45.4 0.0 7.6 2 2 5 7 7 7 7 HEAT repeats Vac14_Fab1_bd PF12755.7 CCF52548.1 - 3.9e-12 46.6 0.4 0.0073 16.9 0.0 6.8 4 2 4 8 8 8 4 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.6 CCF52548.1 - 1.7e-11 44.3 8.1 0.23 12.0 0.0 8.7 7 1 2 9 9 9 2 HEAT-like repeat Cnd1 PF12717.7 CCF52548.1 - 7e-10 39.2 6.7 0.0074 16.4 0.0 5.6 4 2 1 6 6 6 2 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 CCF52548.1 - 3.8e-08 32.3 5.5 0.061 11.9 0.1 4.8 2 1 1 4 4 4 3 Adaptin N terminal region RTP1_C1 PF10363.9 CCF52548.1 - 0.00023 21.3 3.4 5 7.4 0.0 4.3 2 2 1 3 3 3 2 Required for nuclear transport of RNA pol II C-terminus 1 CLASP_N PF12348.8 CCF52548.1 - 0.0078 15.8 1.7 0.89 9.1 0.1 4.0 2 2 3 5 5 5 1 CLASP N terminal HEAT_PBS PF03130.16 CCF52548.1 - 0.011 16.4 0.5 22 6.1 0.0 5.0 4 0 0 4 4 4 0 PBS lyase HEAT-like repeat V-ATPase_H_N PF03224.14 CCF52548.1 - 0.012 15.0 0.9 0.16 11.2 0.9 2.7 1 1 0 1 1 1 0 V-ATPase subunit H Proteasom_PSMB PF10508.9 CCF52548.1 - 0.085 11.3 1.8 22 3.4 0.1 3.4 4 0 0 4 4 4 0 Proteasome non-ATPase 26S subunit Ada3 PF10198.9 CCF52549.1 - 1.5e-32 112.5 0.5 1.5e-32 112.5 0.5 2.0 2 0 0 2 2 2 1 Histone acetyltransferases subunit 3 Oxysterol_BP PF01237.18 CCF52550.1 - 5.2e-50 170.3 0.1 9.3e-31 107.0 0.1 3.1 2 1 0 2 2 2 2 Oxysterol-binding protein RNase_P_pop3 PF08228.11 CCF52551.1 - 0.00069 19.7 0.0 0.0021 18.1 0.0 1.8 2 0 0 2 2 2 1 RNase P subunit Pop3 Gtr1_RagA PF04670.12 CCF52552.1 - 1.7e-24 86.5 0.0 5.7e-10 38.9 0.0 4.1 4 0 0 4 4 4 3 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 CCF52552.1 - 0.0066 16.5 0.0 0.019 15.1 0.0 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.6 CCF52552.1 - 0.022 15.1 0.0 0.072 13.5 0.0 1.9 2 0 0 2 2 2 0 AAA ATPase domain Arf PF00025.21 CCF52552.1 - 0.066 12.7 0.1 1.7 8.0 0.1 2.1 2 0 0 2 2 2 0 ADP-ribosylation factor family AAA_14 PF13173.6 CCF52552.1 - 0.1 12.7 0.0 0.22 11.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain Pex24p PF06398.11 CCF52553.1 - 2.7e-26 92.4 0.4 2.7e-26 92.4 0.4 2.3 2 0 0 2 2 2 2 Integral peroxisomal membrane peroxin Sin_N PF04801.13 CCF52554.1 - 8.1e-36 124.2 0.0 1.3e-35 123.5 0.0 1.3 1 0 0 1 1 1 1 Sin-like protein conserved region NDK PF00334.19 CCF52555.1 - 4.1e-49 166.1 0.0 5.2e-49 165.7 0.0 1.1 1 0 0 1 1 1 1 Nucleoside diphosphate kinase LSM PF01423.22 CCF52556.1 - 6.5e-17 61.0 1.4 9.2e-17 60.5 1.4 1.2 1 0 0 1 1 1 1 LSM domain Hfq PF17209.3 CCF52556.1 - 0.16 11.6 0.1 0.32 10.7 0.1 1.4 1 0 0 1 1 1 0 Hfq protein UQ_con PF00179.26 CCF52557.1 - 3.1e-37 127.4 0.1 3.8e-37 127.1 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme LETM1 PF07766.13 CCF52558.1 - 1.3e-24 87.0 7.3 1.4e-24 86.9 1.5 2.5 2 1 0 2 2 2 1 LETM1-like protein DUF5088 PF17008.5 CCF52558.1 - 0.11 12.2 0.0 0.19 11.4 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5088) CREPT PF16566.5 CCF52558.1 - 2.1 8.5 14.7 0.17 12.1 3.7 3.1 3 0 0 3 3 3 0 Cell-cycle alteration and expression-elevated protein in tumour DUF1729 PF08354.10 CCF52559.1 - 3.7e-161 535.9 0.0 6.1e-161 535.2 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1729) FAS_I_H PF18314.1 CCF52559.1 - 1.4e-76 256.7 0.4 2.5e-76 255.9 0.4 1.5 1 0 0 1 1 1 1 Fatty acid synthase type I helical domain Fas_alpha_ACP PF18325.1 CCF52559.1 - 1.6e-68 230.1 0.0 3.1e-68 229.2 0.0 1.5 1 0 0 1 1 1 1 Fatty acid synthase subunit alpha Acyl carrier domain Acyl_transf_1 PF00698.21 CCF52559.1 - 1.3e-60 205.6 0.0 4.2e-60 203.9 0.0 1.9 1 0 0 1 1 1 1 Acyl transferase domain FAS_meander PF17951.1 CCF52559.1 - 8.2e-47 158.7 0.0 1.7e-46 157.6 0.0 1.6 1 0 0 1 1 1 1 Fatty acid synthase meander beta sheet domain SAT PF16073.5 CCF52559.1 - 3.2e-29 102.3 0.0 7.3e-29 101.2 0.0 1.6 1 0 0 1 1 1 1 Starter unit:ACP transacylase in aflatoxin biosynthesis MaoC_dehydratas PF01575.19 CCF52559.1 - 6.9e-27 93.5 0.1 5.9e-26 90.5 0.0 2.3 2 0 0 2 2 2 1 MaoC like domain ketoacyl-synt PF00109.26 CCF52559.1 - 2.7e-26 92.7 0.6 2.7e-26 92.7 0.6 2.3 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 CCF52559.1 - 3.6e-17 62.5 0.4 3.6e-17 62.5 0.4 2.0 2 0 0 2 2 1 1 Beta-ketoacyl synthase, C-terminal domain FAS_N PF17828.1 CCF52559.1 - 6.5e-14 52.0 0.3 1.7e-13 50.7 0.3 1.7 1 0 0 1 1 1 1 N-terminal domain in fatty acid synthase subunit beta ACPS PF01648.20 CCF52559.1 - 4.9e-12 46.0 0.0 1.2e-11 44.7 0.0 1.7 1 0 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily MaoC_dehydrat_N PF13452.6 CCF52559.1 - 2e-08 34.5 0.0 1.3e-07 31.8 0.0 2.3 2 0 0 2 2 2 1 N-terminal half of MaoC dehydratase adh_short PF00106.25 CCF52559.1 - 7.7e-05 22.2 0.1 0.00043 19.8 0.0 2.2 2 0 0 2 2 2 1 short chain dehydrogenase Thiolase_N PF00108.23 CCF52559.1 - 0.0053 16.2 0.3 0.021 14.2 0.1 2.0 2 0 0 2 2 2 1 Thiolase, N-terminal domain KR PF08659.10 CCF52559.1 - 0.046 13.6 0.5 1.6 8.6 0.0 2.9 3 0 0 3 3 3 0 KR domain zf-RING_2 PF13639.6 CCF52560.1 - 3.4e-10 40.1 7.9 5.7e-10 39.4 7.9 1.4 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 CCF52560.1 - 1.1e-07 32.0 5.3 2.4e-07 30.9 5.3 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 CCF52560.1 - 2.1e-07 30.7 5.7 3.6e-07 29.9 5.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CCF52560.1 - 6.6e-06 26.0 4.7 1.1e-05 25.2 4.7 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 CCF52560.1 - 6.9e-06 26.0 5.0 6.9e-06 26.0 5.0 2.0 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 CCF52560.1 - 1.7e-05 24.5 9.2 0.00023 20.9 9.2 2.2 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 CCF52560.1 - 5.8e-05 22.6 1.7 0.00012 21.6 1.7 1.4 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type Prok-RING_4 PF14447.6 CCF52560.1 - 0.00022 21.0 0.7 0.00022 21.0 0.7 2.3 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 CCF52560.1 - 0.00025 21.0 2.1 0.00046 20.2 2.1 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_11 PF17123.5 CCF52560.1 - 0.0042 16.8 2.9 0.019 14.7 2.9 2.1 1 1 0 1 1 1 1 RING-like zinc finger zf-RING-like PF08746.11 CCF52560.1 - 0.028 14.7 1.0 0.067 13.5 1.0 1.6 1 0 0 1 1 1 0 RING-like domain zf-C3HC4_3 PF13920.6 CCF52560.1 - 0.04 13.8 8.4 0.37 10.7 8.5 2.1 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 CCF52560.1 - 0.097 12.8 0.5 0.097 12.8 0.5 2.3 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING FANCL_C PF11793.8 CCF52560.1 - 0.13 12.5 5.4 0.77 10.0 5.4 2.1 1 1 0 1 1 1 0 FANCL C-terminal domain zf-Nse PF11789.8 CCF52560.1 - 0.14 12.0 5.4 0.3 10.9 5.4 1.5 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit RINGv PF12906.7 CCF52560.1 - 0.19 11.9 4.9 0.54 10.4 4.9 1.8 1 1 0 1 1 1 0 RING-variant domain zf-RING_4 PF14570.6 CCF52560.1 - 0.2 11.5 5.8 0.6 9.9 5.8 1.7 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain PHD_4 PF16866.5 CCF52560.1 - 0.89 9.7 5.9 3.4 7.8 5.9 2.0 1 1 0 1 1 1 0 PHD-finger ATG22 PF11700.8 CCF52562.1 - 1.5e-132 442.7 19.5 1.7e-132 442.5 19.5 1.0 1 0 0 1 1 1 1 Vacuole effluxer Atg22 like MFS_1 PF07690.16 CCF52562.1 - 4.1e-11 42.4 26.9 6.7e-05 22.0 8.4 3.1 2 1 1 3 3 3 3 Major Facilitator Superfamily Pal1 PF08316.11 CCF52563.1 - 3.9e-13 50.3 0.3 3.9e-13 50.3 0.3 2.6 3 0 0 3 3 3 1 Pal1 cell morphology protein LRR_6 PF13516.6 CCF52566.1 - 1.8e-11 43.1 26.3 0.0038 17.2 0.0 9.1 9 0 0 9 9 9 4 Leucine Rich repeat GAT PF03127.14 CCF52566.1 - 0.00074 19.8 0.0 0.0025 18.1 0.0 2.0 1 0 0 1 1 1 1 GAT domain LRR_1 PF00560.33 CCF52566.1 - 0.0086 16.5 14.0 47 5.1 0.1 8.0 10 0 0 10 10 10 0 Leucine Rich Repeat LRR_4 PF12799.7 CCF52566.1 - 0.0097 16.3 24.8 0.36 11.3 1.9 6.3 4 1 1 6 6 6 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 CCF52566.1 - 0.17 11.7 22.3 4.2 7.2 0.0 6.4 4 1 3 7 7 7 0 Leucine rich repeat Torus PF16131.5 CCF52567.1 - 3.3e-29 101.8 4.4 3.3e-29 101.8 4.4 2.4 3 1 0 3 3 3 1 Torus domain RRM_1 PF00076.22 CCF52567.1 - 6.5e-07 29.1 0.0 1.8e-06 27.7 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 CCF52567.1 - 0.0013 18.7 0.0 0.0031 17.5 0.0 1.6 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif zf-CCCH PF00642.24 CCF52567.1 - 0.014 15.3 5.3 0.028 14.3 5.3 1.5 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 CCF52567.1 - 0.47 10.6 4.8 0.85 9.8 4.8 1.4 1 0 0 1 1 1 0 Zinc finger domain ASFV_J13L PF05568.11 CCF52567.1 - 1.7 8.4 5.9 0.35 10.6 2.2 1.7 2 0 0 2 2 2 0 African swine fever virus J13L protein GST_C_2 PF13410.6 CCF52568.1 - 6.4e-15 54.9 0.0 1.5e-14 53.8 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 CCF52568.1 - 7.2e-06 26.3 0.0 1.4e-05 25.4 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 CCF52568.1 - 0.0001 22.5 0.0 0.00021 21.5 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Methyltransf_16 PF10294.9 CCF52569.1 - 4e-05 23.4 0.0 0.16 11.7 0.0 2.3 2 0 0 2 2 2 2 Lysine methyltransferase ILVD_EDD PF00920.21 CCF52570.1 - 1.6e-209 696.8 0.6 1.9e-209 696.6 0.6 1.0 1 0 0 1 1 1 1 Dehydratase family DPBB_1 PF03330.18 CCF52571.1 - 1.8e-08 34.5 0.1 3.2e-08 33.7 0.1 1.4 1 0 0 1 1 1 1 Lytic transglycolase YL1 PF05764.13 CCF52571.1 - 0.0041 17.3 7.6 0.0052 16.9 7.6 1.1 1 0 0 1 1 1 1 YL1 nuclear protein POX PF07526.11 CCF52571.1 - 0.056 14.0 2.0 0.095 13.3 2.0 1.4 1 0 0 1 1 1 0 Associated with HOX NARP1 PF12569.8 CCF52571.1 - 0.064 12.2 3.2 0.086 11.7 3.2 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Spt5_N PF11942.8 CCF52571.1 - 0.26 12.3 10.1 0.38 11.7 10.1 1.3 1 0 0 1 1 1 0 Spt5 transcription elongation factor, acidic N-terminal PI3K_1B_p101 PF10486.9 CCF52571.1 - 0.29 8.9 7.1 0.33 8.7 7.1 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Apt1 PF10351.9 CCF52571.1 - 0.44 9.4 11.1 0.5 9.2 11.1 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain CDC45 PF02724.14 CCF52571.1 - 0.51 8.6 10.2 0.59 8.4 10.2 1.1 1 0 0 1 1 1 0 CDC45-like protein Macoilin PF09726.9 CCF52571.1 - 1.4 7.4 8.8 1.6 7.2 8.8 1.1 1 0 0 1 1 1 0 Macoilin family Nucleo_P87 PF07267.11 CCF52571.1 - 2 7.2 5.8 2.5 6.9 5.8 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 Hid1 PF12722.7 CCF52571.1 - 2.5 6.1 7.5 3.1 5.8 7.5 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Zip PF02535.22 CCF52571.1 - 2.7 7.1 5.1 3.1 6.9 5.1 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter SelP_N PF04592.14 CCF52571.1 - 3.9 6.8 12.5 6.1 6.2 12.5 1.3 1 0 0 1 1 1 0 Selenoprotein P, N terminal region PI-PLC-X PF00388.19 CCF52572.1 - 6.9e-56 187.9 0.0 1.3e-55 187.0 0.0 1.5 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 CCF52572.1 - 4e-40 136.8 0.0 8.7e-40 135.7 0.0 1.6 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain EF-hand_7 PF13499.6 CCF52572.1 - 2.7e-06 27.7 0.2 8.2e-06 26.2 0.2 1.9 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 CCF52572.1 - 0.00017 20.9 0.8 0.16 11.6 0.0 3.3 3 0 0 3 3 3 2 EF hand C2 PF00168.30 CCF52572.1 - 0.0024 18.1 0.0 0.16 12.2 0.0 2.6 2 0 0 2 2 2 1 C2 domain EF-hand_6 PF13405.6 CCF52572.1 - 0.0025 17.6 1.9 0.84 9.7 0.1 3.1 3 0 0 3 3 3 2 EF-hand domain EF-hand_10 PF14788.6 CCF52572.1 - 0.081 12.8 0.1 0.2 11.5 0.1 1.7 1 0 0 1 1 1 0 EF hand OrsD PF12013.8 CCF52573.1 - 1.6 9.2 5.9 0.27 11.7 0.9 2.1 1 1 1 2 2 2 0 Orsellinic acid/F9775 biosynthesis cluster protein D Acyl-CoA_dh_2 PF08028.11 CCF52574.1 - 4.4e-11 43.2 0.4 7.5e-11 42.4 0.4 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 CCF52574.1 - 2.5e-08 34.6 1.2 5e-08 33.6 0.2 1.9 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 CCF52574.1 - 5.5e-05 23.3 0.0 0.00012 22.2 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_1 PF00441.24 CCF52574.1 - 0.014 15.6 0.5 0.053 13.7 0.5 2.0 1 1 0 1 1 1 0 Acyl-CoA dehydrogenase, C-terminal domain ADH_N PF08240.12 CCF52575.1 - 2.6e-05 24.1 0.0 6.4e-05 22.8 0.0 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CCF52575.1 - 0.0015 18.5 0.0 0.0026 17.7 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N_2 PF16884.5 CCF52575.1 - 0.051 13.5 0.0 0.17 11.8 0.0 1.9 1 1 1 2 2 2 0 N-terminal domain of oxidoreductase DUF5470 PF17564.2 CCF52576.1 - 0.021 15.0 0.8 4.8 7.4 0.0 2.9 3 0 0 3 3 3 0 Family of unknown function (DUF5470) HD PF01966.22 CCF52576.1 - 0.033 14.4 0.0 0.12 12.6 0.0 2.0 1 1 0 1 1 1 0 HD domain NIF PF03031.18 CCF52577.1 - 8.3e-24 84.1 0.0 2.1e-23 82.8 0.0 1.7 1 1 0 1 1 1 1 NLI interacting factor-like phosphatase HAD_2 PF13419.6 CCF52577.1 - 0.043 13.9 0.0 0.097 12.7 0.0 1.7 1 1 0 1 1 1 0 Haloacid dehalogenase-like hydrolase HTH_3 PF01381.22 CCF52577.1 - 0.15 12.1 0.2 27 4.9 0.0 4.1 5 0 0 5 5 5 0 Helix-turn-helix SKA1 PF07160.12 CCF52577.1 - 0.23 11.3 0.7 0.37 10.6 0.7 1.2 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 1 WD40 PF00400.32 CCF52578.1 - 4.6e-27 93.7 29.1 3.9e-05 24.3 0.2 7.8 7 0 0 7 7 7 6 WD domain, G-beta repeat F-box-like PF12937.7 CCF52578.1 - 4.4e-08 32.9 1.6 1e-07 31.7 1.6 1.7 1 0 0 1 1 1 1 F-box-like ANAPC4_WD40 PF12894.7 CCF52578.1 - 0.0083 16.4 0.2 13 6.2 0.0 3.5 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 CCF52578.1 - 0.01 14.5 6.9 0.5 8.9 0.0 3.6 2 1 1 4 4 4 0 Nucleoporin Nup120/160 F-box PF00646.33 CCF52578.1 - 0.027 14.3 1.9 0.073 13.0 1.9 1.8 1 0 0 1 1 1 0 F-box domain WD40_like PF17005.5 CCF52578.1 - 0.041 13.2 0.0 0.28 10.5 0.0 2.1 2 0 0 2 2 2 0 WD40-like domain DUF2207 PF09972.9 CCF52579.1 - 0.034 12.9 0.0 0.047 12.5 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) MT-A70 PF05063.14 CCF52581.1 - 4.9e-50 169.8 0.0 2.7e-33 115.3 0.0 2.2 2 0 0 2 2 2 2 MT-A70 adh_short PF00106.25 CCF52582.1 - 7.1e-24 84.3 0.5 1.2e-20 73.8 0.1 2.6 2 1 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CCF52582.1 - 1.3e-17 64.2 1.3 4.2e-14 52.7 0.6 2.7 2 1 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF52582.1 - 1.6e-07 31.4 0.1 2.6e-07 30.7 0.1 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CCF52582.1 - 0.054 13.0 0.0 0.092 12.2 0.0 1.4 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family DUF2018 PF09442.10 CCF52582.1 - 0.17 12.9 0.0 0.43 11.6 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF2018) LRR_8 PF13855.6 CCF52583.1 - 6.1e-19 67.6 19.3 6e-11 41.9 6.0 5.3 4 1 1 5 5 5 4 Leucine rich repeat LRR_4 PF12799.7 CCF52583.1 - 2.5e-17 62.7 14.5 2.4e-05 24.6 2.0 5.4 5 0 0 5 5 5 4 Leucine Rich repeats (2 copies) Torus PF16131.5 CCF52583.1 - 1.4e-07 32.2 4.0 0.0035 18.0 0.4 2.7 1 1 1 2 2 2 2 Torus domain LRR_6 PF13516.6 CCF52583.1 - 9.2e-07 28.4 15.1 0.047 13.7 0.0 7.3 7 0 0 7 7 7 3 Leucine Rich repeat zf-CCCH_4 PF18044.1 CCF52583.1 - 1.1e-06 28.3 8.7 0.0009 19.0 1.2 2.4 2 0 0 2 2 2 2 CCCH-type zinc finger zf-CCCH PF00642.24 CCF52583.1 - 7.9e-06 25.7 6.2 0.00052 19.8 0.7 2.4 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_3 PF15663.5 CCF52583.1 - 0.00063 19.9 0.2 0.0014 18.9 0.2 1.5 1 0 0 1 1 1 1 Zinc-finger containing family zf_CCCH_4 PF18345.1 CCF52583.1 - 0.0015 18.5 15.7 0.0062 16.6 3.4 2.4 2 0 0 2 2 2 2 Zinc finger domain LRR_3 PF07725.12 CCF52583.1 - 0.02 14.7 0.4 0.02 14.7 0.4 2.6 3 0 0 3 3 3 0 Leucine Rich Repeat LRR_1 PF00560.33 CCF52583.1 - 0.12 13.1 19.5 9.5 7.2 0.1 7.5 7 1 0 7 7 6 0 Leucine Rich Repeat COPR5 PF15340.6 CCF52583.1 - 0.28 11.8 1.9 1.1 9.9 1.9 2.0 1 0 0 1 1 1 0 Cooperator of PRMT5 family MAGE PF01454.19 CCF52584.1 - 1.4e-42 145.8 0.0 3.2e-42 144.7 0.0 1.7 1 0 0 1 1 1 1 MAGE family TMP-TENI PF02581.17 CCF52584.1 - 0.062 12.6 0.1 0.11 11.8 0.1 1.3 1 0 0 1 1 1 0 Thiamine monophosphate synthase Ribosomal_L22 PF00237.19 CCF52584.1 - 0.11 12.8 0.2 1.2 9.4 0.0 2.4 2 0 0 2 2 2 0 Ribosomal protein L22p/L17e Mg_trans_NIPA PF05653.14 CCF52585.1 - 9e-108 359.8 16.7 1.1e-107 359.5 16.7 1.1 1 0 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.20 CCF52585.1 - 0.0003 21.0 4.4 0.0003 21.0 4.4 4.0 3 1 0 3 3 3 1 EamA-like transporter family CrgA PF06781.12 CCF52585.1 - 5.9 7.0 6.7 8.1 6.6 0.1 3.6 2 1 1 3 3 3 0 Cell division protein CrgA RRM_1 PF00076.22 CCF52586.1 - 3.9e-25 87.4 0.0 1.3e-11 44.1 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PEMT PF04191.13 CCF52587.1 - 1.4e-55 186.2 8.0 2e-32 111.7 1.2 2.7 2 0 0 2 2 2 2 Phospholipid methyltransferase NPR3 PF03666.13 CCF52588.1 - 7.2e-125 417.4 0.0 7.2e-125 417.4 0.0 3.7 3 0 0 3 3 3 1 Nitrogen Permease regulator of amino acid transport activity 3 NPR2 PF06218.11 CCF52588.1 - 0.06 12.1 0.2 11 4.6 0.0 3.5 4 1 0 4 4 4 0 Nitrogen permease regulator 2 EMC3_TMCO1 PF01956.16 CCF52589.1 - 1.2e-57 194.4 0.2 1.4e-57 194.1 0.2 1.1 1 0 0 1 1 1 1 Integral membrane protein EMC3/TMCO1-like Bot1p PF12298.8 CCF52590.1 - 2e-29 103.0 0.1 4e-29 102.0 0.1 1.5 1 0 0 1 1 1 1 Eukaryotic mitochondrial regulator protein MRP-L20 PF12824.7 CCF52590.1 - 0.0005 20.3 0.0 0.0012 19.1 0.0 1.7 1 0 0 1 1 1 1 Mitochondrial ribosomal protein subunit L20 HemY_N PF07219.13 CCF52592.1 - 0.0073 16.5 1.1 1.1 9.4 0.0 2.6 2 0 0 2 2 2 2 HemY protein N-terminus Phage_holin_3_6 PF07332.11 CCF52592.1 - 0.05 13.7 8.8 0.12 12.4 5.9 2.3 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III MBOAT PF03062.19 CCF52593.1 - 1.4e-50 172.7 15.9 1.4e-50 172.6 14.6 1.5 1 1 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family Clat_adaptor_s PF01217.20 CCF52594.1 - 8.6e-55 184.6 1.0 1e-54 184.3 1.0 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain SCP2 PF02036.17 CCF52595.1 - 1.5e-25 89.6 2.1 1.7e-25 89.4 2.1 1.1 1 0 0 1 1 1 1 SCP-2 sterol transfer family Alkyl_sulf_C PF14864.6 CCF52595.1 - 1.9e-05 25.0 0.6 2.2e-05 24.7 0.6 1.1 1 0 0 1 1 1 1 Alkyl sulfatase C-terminal Aldo_ket_red PF00248.21 CCF52597.1 - 9.2e-12 44.7 0.1 0.00071 18.9 0.0 3.0 2 1 1 3 3 3 3 Aldo/keto reductase family MMR_HSR1_Xtn PF16897.5 CCF52598.1 - 4.5e-40 135.9 0.8 9.2e-40 135.0 0.6 1.7 2 0 0 2 2 2 1 C-terminal region of MMR_HSR1 domain TGS PF02824.21 CCF52598.1 - 1.6e-21 76.1 0.0 2.9e-21 75.3 0.0 1.5 1 0 0 1 1 1 1 TGS domain MMR_HSR1 PF01926.23 CCF52598.1 - 5.4e-21 74.8 0.2 1.4e-20 73.4 0.0 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 CCF52598.1 - 6.4e-09 35.5 0.2 1.6e-08 34.2 0.0 1.7 2 0 0 2 2 2 1 Ferrous iron transport protein B Dynamin_N PF00350.23 CCF52598.1 - 0.084 12.9 2.1 1 9.4 0.0 2.5 2 1 1 3 3 3 0 Dynamin family MeaB PF03308.16 CCF52598.1 - 0.1 11.5 2.1 0.13 11.2 0.5 1.9 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Cyt-b5 PF00173.28 CCF52599.1 - 2e-09 37.4 0.2 2.3e-09 37.2 0.2 1.1 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain PNP_phzG_C PF10590.9 CCF52600.1 - 2.7e-22 78.5 0.5 5.4e-22 77.6 0.5 1.5 1 0 0 1 1 1 1 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region Putative_PNPOx PF01243.20 CCF52600.1 - 3.1e-17 62.6 0.0 4.7e-17 62.0 0.0 1.3 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Pyridox_oxase_2 PF12766.7 CCF52600.1 - 0.011 16.3 0.0 0.023 15.3 0.0 1.5 1 0 0 1 1 1 0 Pyridoxamine 5'-phosphate oxidase BrnA_antitoxin PF14384.6 CCF52601.1 - 0.041 14.4 0.0 0.07 13.6 0.0 1.4 1 0 0 1 1 1 0 BrnA antitoxin of type II toxin-antitoxin system DUF2981 PF11200.8 CCF52601.1 - 0.045 13.5 0.3 0.12 12.1 0.5 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2981) MatE PF01554.18 CCF52601.1 - 0.047 13.3 4.1 1.9 8.1 1.1 2.3 2 1 0 2 2 2 0 MatE PNTB_4TM PF12769.7 CCF52601.1 - 0.063 13.8 1.4 0.12 12.8 1.4 1.4 1 0 0 1 1 1 0 4TM region of pyridine nucleotide transhydrogenase, mitoch Tetraspanin PF00335.20 CCF52601.1 - 3 7.5 12.0 0.29 10.8 6.4 1.9 1 1 1 2 2 2 0 Tetraspanin family Amidohydro_3 PF07969.11 CCF52602.1 - 1e-71 242.9 0.1 1.2e-71 242.7 0.1 1.0 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_1 PF01979.20 CCF52602.1 - 1.3e-16 60.9 0.0 2.7e-12 46.7 0.0 2.4 2 1 0 2 2 2 2 Amidohydrolase family SpoVS PF04232.12 CCF52602.1 - 0.0077 15.9 0.0 0.023 14.4 0.1 1.8 2 0 0 2 2 2 1 Stage V sporulation protein S (SpoVS) EAP30 PF04157.16 CCF52604.1 - 2.1e-30 105.8 0.0 3.1e-30 105.2 0.0 1.3 1 0 0 1 1 1 1 EAP30/Vps36 family Vps36_ESCRT-II PF11605.8 CCF52604.1 - 1.4e-25 89.3 0.0 2.6e-25 88.4 0.0 1.4 1 0 0 1 1 1 1 Vacuolar protein sorting protein 36 Vps36 zf-RanBP PF00641.18 CCF52604.1 - 6.9e-06 25.3 11.1 0.0028 16.9 2.5 2.4 2 0 0 2 2 2 2 Zn-finger in Ran binding protein and others Nif11 PF07862.11 CCF52604.1 - 0.0079 16.5 1.7 0.019 15.3 1.7 1.6 1 0 0 1 1 1 1 Nif11 domain Adaptin_binding PF10199.9 CCF52604.1 - 0.024 15.2 0.5 8.3 7.0 0.1 2.6 2 0 0 2 2 2 0 Alpha and gamma adaptin binding protein p34 Vps36-NZF-N PF16988.5 CCF52604.1 - 0.14 11.5 11.3 0.033 13.6 3.3 3.2 2 2 0 2 2 2 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain HIPIP PF01355.17 CCF52604.1 - 0.41 11.0 3.5 17 5.9 0.4 2.6 2 0 0 2 2 2 0 High potential iron-sulfur protein Zf_RING PF16744.5 CCF52604.1 - 0.72 10.0 3.0 15 5.8 0.2 2.5 2 0 0 2 2 2 0 KIAA1045 RING finger DZR PF12773.7 CCF52604.1 - 0.99 9.5 5.9 5 7.2 5.9 2.0 1 1 0 1 1 1 0 Double zinc ribbon DUF35_N PF12172.8 CCF52604.1 - 8.4 6.4 6.5 0.34 10.8 0.4 1.8 2 0 0 2 2 2 0 Rubredoxin-like zinc ribbon domain (DUF35_N) CLU PF13236.6 CCF52605.1 - 1.7e-76 257.0 0.0 2.5e-76 256.4 0.0 1.3 1 0 0 1 1 1 1 Clustered mitochondria eIF3_p135 PF12807.7 CCF52605.1 - 2e-46 158.3 0.0 5.6e-46 156.8 0.0 1.8 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit 135 TPR_12 PF13424.6 CCF52605.1 - 6.8e-18 64.7 5.7 4.5e-07 30.1 0.9 4.3 2 1 2 4 4 4 4 Tetratricopeptide repeat TPR_10 PF13374.6 CCF52605.1 - 1.6e-14 53.2 6.8 0.0012 18.7 0.1 5.6 5 0 0 5 5 5 5 Tetratricopeptide repeat CLU_N PF15044.6 CCF52605.1 - 9e-06 26.0 0.0 4.4e-05 23.8 0.0 2.2 1 1 0 1 1 1 1 Mitochondrial function, CLU-N-term DUF727 PF05303.12 CCF52605.1 - 0.0019 18.2 0.0 0.083 13.0 0.0 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF727) GETHR PF05671.11 CCF52605.1 - 0.23 10.9 28.4 0.33 10.4 15.7 2.5 1 1 1 2 2 2 0 GETHR pentapeptide repeat (5 copies) HMG-CoA_red PF00368.18 CCF52606.1 - 3.1e-142 473.9 5.3 4.6e-142 473.4 5.3 1.2 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A reductase Sterol-sensing PF12349.8 CCF52606.1 - 2e-16 60.2 2.0 7.6e-08 32.3 0.1 2.8 2 0 0 2 2 2 2 Sterol-sensing domain of SREBP cleavage-activation Patched PF02460.18 CCF52606.1 - 3.5e-06 25.4 4.6 0.00048 18.3 0.0 2.7 3 0 0 3 3 3 2 Patched family HPIH PF13323.6 CCF52606.1 - 0.0056 16.5 0.9 0.014 15.3 0.9 1.6 1 0 0 1 1 1 1 N-terminal domain with HPIH motif Neuromodulin PF06614.11 CCF52606.1 - 4.7 7.3 13.1 4.6 7.4 11.0 2.0 2 0 0 2 2 2 0 Neuromodulin PITH PF06201.13 CCF52607.1 - 1e-32 113.4 0.0 1.3e-32 113.1 0.0 1.1 1 0 0 1 1 1 1 PITH domain C2 PF00168.30 CCF52608.1 - 5.5e-29 100.5 0.1 7.9e-18 64.7 0.0 2.9 2 0 0 2 2 2 2 C2 domain MG2 PF01835.19 CCF52609.1 - 0.034 14.6 0.0 0.11 13.0 0.0 1.8 1 1 0 1 1 1 0 MG2 domain Ribosomal_L38e PF01781.18 CCF52610.1 - 2.2e-33 114.2 1.5 2.5e-33 114.0 1.5 1.0 1 0 0 1 1 1 1 Ribosomal L38e protein family E6 PF00518.17 CCF52610.1 - 0.012 16.1 0.0 0.012 16.0 0.0 1.1 1 0 0 1 1 1 0 Early Protein (E6) Ribosomal_S11 PF00411.19 CCF52611.1 - 4.7e-47 158.9 1.9 6.1e-47 158.6 1.9 1.1 1 0 0 1 1 1 1 Ribosomal protein S11 DUF2252 PF10009.9 CCF52611.1 - 0.073 12.1 0.0 0.094 11.8 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2252) CBM_25 PF03423.13 CCF52611.1 - 0.08 13.2 0.1 0.19 12.0 0.0 1.6 2 0 0 2 2 2 0 Carbohydrate binding domain (family 25) EVE PF01878.18 CCF52612.1 - 1.4e-39 135.4 1.1 2.9e-39 134.4 0.0 2.0 2 1 0 2 2 2 1 EVE domain DUF3416 PF11896.8 CCF52612.1 - 0.17 12.2 5.0 0.33 11.2 4.8 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF3416) TLP-20 PF06088.11 CCF52612.1 - 0.7 9.8 4.6 0.98 9.3 4.6 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) RR_TM4-6 PF06459.12 CCF52612.1 - 3 7.6 7.4 3.9 7.2 7.4 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Mpv17_PMP22 PF04117.12 CCF52613.1 - 1.1e-22 80.0 0.4 1.8e-22 79.3 0.4 1.4 1 0 0 1 1 1 1 Mpv17 / PMP22 family BCIP PF13862.6 CCF52616.1 - 4.6e-51 173.5 0.0 5.7e-51 173.2 0.0 1.1 1 0 0 1 1 1 1 p21-C-terminal region-binding protein SNX17_FERM_C PF18116.1 CCF52617.1 - 0.081 13.0 0.0 0.16 12.0 0.0 1.5 1 0 0 1 1 1 0 Sorting Nexin 17 FERM C-terminal domain Peptidase_S8 PF00082.22 CCF52619.1 - 4.6e-44 150.9 4.1 7.1e-44 150.2 4.1 1.3 1 0 0 1 1 1 1 Subtilase family fn3_5 PF06280.12 CCF52619.1 - 9.5e-18 65.0 0.8 8.5e-17 61.9 0.1 2.6 2 0 0 2 2 2 1 Fn3-like domain Inhibitor_I9 PF05922.16 CCF52619.1 - 0.00029 21.5 0.0 0.00068 20.3 0.0 1.6 1 0 0 1 1 1 1 Peptidase inhibitor I9 PA PF02225.22 CCF52619.1 - 0.001 19.1 0.0 0.0032 17.5 0.0 1.9 1 0 0 1 1 1 1 PA domain RPT PF13446.6 CCF52619.1 - 0.069 13.1 0.0 0.15 12.0 0.0 1.5 1 0 0 1 1 1 0 A repeated domain in UCH-protein Ribonuclease_T2 PF00445.18 CCF52620.1 - 2.1e-32 112.9 1.0 3.1e-32 112.3 1.0 1.2 1 0 0 1 1 1 1 Ribonuclease T2 family MutS_V PF00488.21 CCF52621.1 - 3.5e-80 268.5 0.1 5.8e-80 267.8 0.1 1.4 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 CCF52621.1 - 9.3e-35 120.6 3.1 2.2e-34 119.3 0.5 2.4 2 0 0 2 2 2 1 MutS domain III MutS_II PF05188.17 CCF52621.1 - 1e-18 67.9 0.0 3.5e-18 66.2 0.0 1.9 1 0 0 1 1 1 1 MutS domain II MutS_IV PF05190.18 CCF52621.1 - 3.4e-14 52.9 0.2 3.4e-14 52.9 0.2 2.5 3 0 0 3 3 3 1 MutS family domain IV MutS_I PF01624.20 CCF52621.1 - 1e-13 51.5 0.0 1.9e-13 50.6 0.0 1.5 1 0 0 1 1 1 1 MutS domain I FBA PF04300.13 CCF52621.1 - 0.063 13.0 0.1 0.48 10.1 0.0 2.1 2 0 0 2 2 2 0 F-box associated region Thiamine_BP PF01910.17 CCF52622.1 - 1.4e-23 82.6 0.0 1.8e-23 82.3 0.0 1.1 1 0 0 1 1 1 1 Thiamine-binding protein Mon1 PF03164.14 CCF52623.1 - 4.8e-94 315.7 0.0 1.4e-88 297.7 0.0 3.0 2 1 0 2 2 2 2 Trafficking protein Mon1 Mg_trans_NIPA PF05653.14 CCF52624.1 - 2.3e-26 92.6 8.6 4.7e-13 48.9 0.3 2.1 2 0 0 2 2 2 2 Magnesium transporter NIPA DUF1771 PF08590.10 CCF52625.1 - 1.5e-22 79.7 5.0 1.5e-22 79.7 5.0 2.9 3 0 0 3 3 3 1 Domain of unknown function (DUF1771) Smr PF01713.21 CCF52625.1 - 1e-11 45.0 0.6 2.2e-11 43.9 0.6 1.6 1 0 0 1 1 1 1 Smr domain Peripla_BP_2 PF01497.18 CCF52625.1 - 0.015 14.9 0.1 0.022 14.3 0.1 1.4 1 1 0 1 1 1 0 Periplasmic binding protein SUI1 PF01253.22 CCF52626.1 - 1.2e-13 51.4 0.0 2.3e-13 50.4 0.0 1.5 1 0 0 1 1 1 1 Translation initiation factor SUI1 TnpV PF14198.6 CCF52626.1 - 0.012 15.6 0.1 0.016 15.2 0.1 1.2 1 0 0 1 1 1 0 Transposon-encoded protein TnpV ArfGap PF01412.18 CCF52629.1 - 3.8e-40 136.6 0.1 3.8e-40 136.6 0.1 2.4 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf MecA PF05389.12 CCF52629.1 - 1.1 8.8 11.1 0.35 10.4 8.0 1.6 2 0 0 2 2 2 0 Negative regulator of genetic competence (MecA) AAA_23 PF13476.6 CCF52629.1 - 1.9 8.9 16.3 11 6.4 15.3 2.0 2 0 0 2 2 2 0 AAA domain DUF4407 PF14362.6 CCF52629.1 - 2.6 7.3 9.5 4.3 6.6 9.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Baculo_PP31 PF05311.11 CCF52629.1 - 3.6 7.0 11.0 7 6.1 11.0 1.3 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) Peptidase_S49_N PF08496.10 CCF52629.1 - 9.3 6.3 9.1 17 5.5 9.1 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal DENN PF02141.21 CCF52630.1 - 6.3e-19 68.6 0.0 1e-18 67.9 0.0 1.4 1 0 0 1 1 1 1 DENN (AEX-3) domain Methyltransf_16 PF10294.9 CCF52630.1 - 2.9e-10 40.2 0.0 7.3e-10 38.8 0.0 1.6 1 0 0 1 1 1 1 Lysine methyltransferase FlxA PF14282.6 CCF52630.1 - 0.025 14.5 16.9 0.69 9.9 4.3 2.7 2 0 0 2 2 2 0 FlxA-like protein Spc7 PF08317.11 CCF52630.1 - 0.053 12.4 15.1 0.014 14.3 9.1 2.3 2 0 0 2 2 2 0 Spc7 kinetochore protein Cluap1 PF10234.9 CCF52630.1 - 0.23 10.9 13.0 0.032 13.6 6.0 2.2 2 0 0 2 2 2 0 Clusterin-associated protein-1 FUSC PF04632.12 CCF52630.1 - 0.46 9.0 6.9 1.2 7.6 6.9 1.6 1 0 0 1 1 1 0 Fusaric acid resistance protein family IFT57 PF10498.9 CCF52630.1 - 0.54 9.2 10.4 1.5 7.8 0.3 2.5 2 0 0 2 2 2 0 Intra-flagellar transport protein 57 Transcrip_act PF04949.13 CCF52630.1 - 1.7 8.5 8.7 0.64 9.9 5.5 1.9 2 0 0 2 2 2 0 Transcriptional activator UPF0242 PF06785.11 CCF52630.1 - 5.1 7.1 14.9 3.6 7.7 6.6 2.4 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus WXG100 PF06013.12 CCF52630.1 - 5.3 7.4 11.7 6.6 7.0 0.5 3.6 3 0 0 3 3 3 0 Proteins of 100 residues with WXG Baculo_PEP_C PF04513.12 CCF52630.1 - 6 6.9 9.8 2.2 8.3 0.6 3.0 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Laminin_II PF06009.12 CCF52630.1 - 7.1 6.7 7.7 5.9 6.9 0.2 3.1 2 1 1 3 3 3 0 Laminin Domain II DUF641 PF04859.12 CCF52630.1 - 9.5 6.6 9.7 5.4 7.4 3.1 2.7 2 0 0 2 2 2 0 Plant protein of unknown function (DUF641) Mpp10 PF04006.12 CCF52631.1 - 5.9e-109 365.2 130.2 3.8e-93 313.0 49.1 3.2 1 1 1 3 3 3 3 Mpp10 protein DAAD PF18752.1 CCF52631.1 - 0.038 13.8 2.4 0.12 12.3 2.4 1.8 1 0 0 1 1 1 0 Dictyosteliid AID/APOBEC-like Deaminase Methyltransf_11 PF08241.12 CCF52632.1 - 1.8e-19 70.2 0.0 4.6e-19 68.9 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCF52632.1 - 2.4e-19 69.8 0.0 3.9e-19 69.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF52632.1 - 2.2e-14 53.9 0.0 7.4e-14 52.2 0.0 1.9 2 1 1 3 3 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF52632.1 - 5.5e-13 49.5 0.0 1.6e-12 48.0 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF52632.1 - 4.7e-12 45.9 0.0 1.6e-11 44.3 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_9 PF08003.11 CCF52632.1 - 2.8e-05 23.2 0.0 4.7e-05 22.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) PrmA PF06325.13 CCF52632.1 - 4.1e-05 23.1 0.0 5.9e-05 22.6 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) CMAS PF02353.20 CCF52632.1 - 0.0002 20.7 0.0 0.00048 19.5 0.0 1.5 1 1 0 1 1 1 1 Mycolic acid cyclopropane synthetase Ubie_methyltran PF01209.18 CCF52632.1 - 0.0043 16.4 0.0 0.0066 15.8 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.14 CCF52632.1 - 0.0068 16.0 0.0 0.013 15.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_32 PF13679.6 CCF52632.1 - 0.018 15.0 0.1 0.063 13.3 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase domain NodS PF05401.11 CCF52632.1 - 0.053 13.1 0.0 0.27 10.8 0.0 1.9 1 1 0 1 1 1 0 Nodulation protein S (NodS) DcpS_C PF11969.8 CCF52633.1 - 2.7e-23 82.6 0.2 3.6e-23 82.2 0.2 1.1 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding HIT PF01230.23 CCF52633.1 - 2e-10 41.3 3.7 1.3e-09 38.7 3.7 2.0 1 1 0 1 1 1 1 HIT domain CwfJ_C_1 PF04677.15 CCF52633.1 - 0.021 14.7 0.4 0.055 13.3 0.4 1.7 1 1 0 1 1 1 0 Protein similar to CwfJ C-terminus 1 Hydrolase_4 PF12146.8 CCF52634.1 - 1.7e-43 148.7 0.0 4.1e-43 147.4 0.0 1.6 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 CCF52634.1 - 4.1e-10 39.8 1.4 5.4e-06 26.2 0.3 2.8 2 1 1 3 3 3 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CCF52634.1 - 4.2e-08 34.1 0.0 5.1e-08 33.8 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_3 PF07859.13 CCF52634.1 - 0.00078 19.4 0.0 0.0019 18.1 0.0 1.6 2 0 0 2 2 2 1 alpha/beta hydrolase fold DUF915 PF06028.11 CCF52634.1 - 0.056 12.8 0.0 1.1 8.5 0.0 2.3 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF915) Peptidase_S9 PF00326.21 CCF52634.1 - 0.072 12.6 0.0 0.95 8.9 0.0 2.2 2 0 0 2 2 2 0 Prolyl oligopeptidase family TruB_N PF01509.18 CCF52635.1 - 3.6e-38 131.2 0.0 2.4e-37 128.6 0.0 2.0 2 0 0 2 2 2 1 TruB family pseudouridylate synthase (N terminal domain) TruB_C_2 PF16198.5 CCF52635.1 - 0.00044 20.4 0.0 0.0013 18.9 0.0 1.8 1 0 0 1 1 1 1 tRNA pseudouridylate synthase B C-terminal domain DEC-1_N PF04625.13 CCF52635.1 - 7.2 5.5 7.4 0.11 11.5 0.3 1.5 2 0 0 2 2 2 0 DEC-1 protein, N-terminal region HTH_9 PF08221.11 CCF52636.1 - 4.1e-18 65.2 0.3 4e-07 30.0 0.0 4.8 5 0 0 5 5 5 4 RNA polymerase III subunit RPC82 helix-turn-helix domain RNA_pol_Rpc82 PF05645.13 CCF52636.1 - 8.3e-15 55.2 0.5 9.6e-13 48.5 0.3 2.6 2 0 0 2 2 2 2 RNA polymerase III subunit RPC82 TFIIE_alpha PF02002.17 CCF52636.1 - 2.5e-06 27.3 0.3 3.4e-05 23.7 0.1 2.6 2 0 0 2 2 2 1 TFIIE alpha subunit DUF4078 PF13300.6 CCF52637.1 - 3.9e-11 43.1 15.2 3.9e-11 43.1 15.2 3.1 3 1 0 3 3 3 1 Domain of unknown function (DUF4078) DUF2464 PF10240.9 CCF52637.1 - 0.052 13.1 1.0 0.083 12.4 1.0 1.4 1 0 0 1 1 1 0 Multivesicular body subunit 12 MelC1 PF06236.11 CCF52637.1 - 0.15 12.1 1.2 0.81 9.8 0.0 2.2 1 1 1 2 2 2 0 Tyrosinase co-factor MelC1 WD40 PF00400.32 CCF52638.1 - 1e-41 140.1 11.5 2.7e-09 37.5 0.1 8.1 8 0 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF52638.1 - 5.4e-11 42.7 1.7 0.11 12.8 0.1 5.1 3 2 2 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CCF52638.1 - 2.9e-06 26.5 0.1 2.2 7.2 0.0 3.9 2 1 2 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein PALB2_WD40 PF16756.5 CCF52638.1 - 0.00025 20.1 0.2 0.00071 18.6 0.1 1.8 2 0 0 2 2 2 1 Partner and localizer of BRCA2 WD40 domain Nup160 PF11715.8 CCF52638.1 - 0.00036 19.3 9.5 0.3 9.7 0.0 4.4 3 2 1 5 5 5 2 Nucleoporin Nup120/160 Frtz PF11768.8 CCF52638.1 - 0.048 12.0 0.0 0.091 11.1 0.0 1.4 1 0 0 1 1 1 0 WD repeat-containing and planar cell polarity effector protein Fritz VID27 PF08553.10 CCF52638.1 - 0.05 12.7 0.0 0.19 10.7 0.0 1.8 2 0 0 2 2 2 0 VID27 C-terminal WD40-like domain Nucleoporin_N PF08801.11 CCF52638.1 - 0.11 11.2 0.3 2.9 6.5 0.0 3.2 2 1 0 4 4 4 0 Nup133 N terminal like dsrm PF00035.26 CCF52639.1 - 6.3e-07 30.0 0.0 1.3e-06 29.0 0.0 1.6 1 0 0 1 1 1 1 Double-stranded RNA binding motif Ribonuclease_3 PF00636.26 CCF52639.1 - 6.5e-07 29.9 0.0 1.6e-06 28.7 0.0 1.7 1 0 0 1 1 1 1 Ribonuclease III domain Ribonucleas_3_3 PF14622.6 CCF52639.1 - 1.4e-06 28.5 0.0 0.16 12.2 0.0 3.1 3 0 0 3 3 3 2 Ribonuclease-III-like TFIIF_beta PF02270.15 CCF52640.1 - 5e-31 106.6 0.3 8.7e-31 105.9 0.3 1.4 1 0 0 1 1 1 1 TFIIF, beta subunit HTH domain TFIIF_beta_N PF17683.1 CCF52640.1 - 1.6e-21 77.4 0.5 3.4e-21 76.4 0.0 1.8 2 0 0 2 2 2 1 TFIIF, beta subunit N-terminus PGA2 PF07543.12 CCF52640.1 - 0.7 9.9 6.4 1 9.3 1.8 2.4 2 0 0 2 2 2 0 Protein trafficking PGA2 TFIIF_alpha PF05793.12 CCF52640.1 - 5.3 5.5 16.9 5.4 5.5 0.3 2.3 2 0 0 2 2 2 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) AA_permease_2 PF13520.6 CCF52641.1 - 3.1e-65 220.7 44.4 3.9e-65 220.3 44.4 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 CCF52641.1 - 2.1e-21 76.1 38.8 2.7e-21 75.7 38.8 1.0 1 0 0 1 1 1 1 Amino acid permease Gram_pos_anchor PF00746.21 CCF52641.1 - 0.00018 21.3 3.0 0.00077 19.3 0.0 3.3 2 0 0 2 2 2 1 LPXTG cell wall anchor motif HSF_DNA-bind PF00447.17 CCF52642.1 - 1e-29 103.0 0.5 2e-29 102.0 0.5 1.5 1 0 0 1 1 1 1 HSF-type DNA-binding Chitin_synth_2 PF03142.15 CCF52643.1 - 2.9e-255 847.9 0.1 3.7e-255 847.5 0.1 1.1 1 0 0 1 1 1 1 Chitin synthase Cyt-b5 PF00173.28 CCF52643.1 - 4.1e-21 74.9 0.3 4.3e-15 55.6 0.0 3.6 3 1 0 3 3 3 2 Cytochrome b5-like Heme/Steroid binding domain DEK_C PF08766.11 CCF52643.1 - 5.7e-16 58.2 0.0 1.3e-13 50.6 0.0 2.6 2 0 0 2 2 2 1 DEK C terminal domain Glyco_tranf_2_3 PF13641.6 CCF52643.1 - 1e-09 38.6 0.0 8.7e-09 35.6 0.0 2.1 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.6 CCF52643.1 - 2.7e-09 37.2 7.3 2.7e-09 37.2 7.3 2.5 2 1 0 2 2 2 1 Glycosyl transferase family group 2 Glycos_transf_2 PF00535.26 CCF52643.1 - 6e-06 26.2 0.0 0.0056 16.5 0.0 2.5 2 0 0 2 2 2 2 Glycosyl transferase family 2 Glyco_transf_21 PF13506.6 CCF52643.1 - 0.00014 21.3 0.0 0.00049 19.6 0.0 1.8 1 0 0 1 1 1 1 Glycosyl transferase family 21 Jiv90 PF14901.6 CCF52643.1 - 0.17 12.0 0.2 6.5 7.0 0.0 2.6 2 0 0 2 2 2 0 Cleavage inducing molecular chaperone RVT_2 PF07727.14 CCF52644.1 - 7.6e-33 114.1 0.1 1e-32 113.8 0.1 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Aim19 PF10315.9 CCF52645.1 - 4.5e-18 65.6 7.5 1.9e-17 63.6 7.4 2.0 1 1 0 1 1 1 1 Altered inheritance of mitochondria protein 19 Aa_trans PF01490.18 CCF52647.1 - 9.2e-29 100.4 27.7 1.4e-28 99.8 27.7 1.2 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein ABC_membrane PF00664.23 CCF52649.1 - 7.1e-40 137.4 24.0 3.5e-26 92.5 11.7 2.5 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 CCF52649.1 - 9.4e-39 133.1 0.0 5.8e-23 81.9 0.0 2.8 2 1 0 2 2 2 2 ABC transporter SMC_N PF02463.19 CCF52649.1 - 1.5e-10 40.9 0.0 0.00033 20.2 0.3 3.8 2 2 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 CCF52649.1 - 5.1e-07 29.8 0.5 0.15 11.9 0.0 3.5 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system T2SSE PF00437.20 CCF52649.1 - 9.3e-06 24.9 0.2 0.12 11.4 0.0 2.4 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_22 PF13401.6 CCF52649.1 - 1.2e-05 25.7 0.4 0.49 10.7 0.0 3.6 3 0 0 3 3 3 2 AAA domain AAA_29 PF13555.6 CCF52649.1 - 5.5e-05 22.8 1.8 0.015 15.1 0.1 3.0 2 0 0 2 2 2 1 P-loop containing region of AAA domain DUF87 PF01935.17 CCF52649.1 - 0.00028 21.1 2.2 0.011 15.8 0.1 2.5 2 0 0 2 2 2 1 Helicase HerA, central domain AAA_16 PF13191.6 CCF52649.1 - 0.00071 20.0 1.4 0.077 13.4 0.1 3.1 3 1 0 3 3 2 1 AAA ATPase domain AAA_23 PF13476.6 CCF52649.1 - 0.00077 20.0 0.9 0.49 10.9 0.0 2.4 2 0 0 2 2 2 1 AAA domain SbcCD_C PF13558.6 CCF52649.1 - 0.0033 17.6 0.6 0.47 10.7 0.3 3.1 2 0 0 2 2 2 1 Putative exonuclease SbcCD, C subunit MMR_HSR1 PF01926.23 CCF52649.1 - 0.0052 16.8 1.0 0.039 14.0 0.0 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CCF52649.1 - 0.0069 16.3 0.4 4.6 7.1 0.0 2.5 2 0 0 2 2 2 1 RsgA GTPase TrwB_AAD_bind PF10412.9 CCF52649.1 - 0.01 14.8 0.3 0.38 9.6 0.0 2.2 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain FtsK_SpoIIIE PF01580.18 CCF52649.1 - 0.012 15.0 2.4 0.6 9.4 0.2 2.4 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_25 PF13481.6 CCF52649.1 - 0.017 14.7 2.6 2.2 7.8 0.2 2.9 3 0 0 3 3 3 0 AAA domain MeaB PF03308.16 CCF52649.1 - 0.017 14.1 0.1 0.032 13.2 0.1 1.3 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Pox_A32 PF04665.12 CCF52649.1 - 0.017 14.6 1.5 1.9 7.9 0.2 2.4 2 0 0 2 2 2 0 Poxvirus A32 protein AAA PF00004.29 CCF52649.1 - 0.021 15.2 0.7 13 6.2 0.0 3.4 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 CCF52649.1 - 0.023 14.2 0.2 5.9 6.4 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_33 PF13671.6 CCF52649.1 - 0.033 14.3 0.4 6.2 7.0 0.0 2.6 2 0 0 2 2 2 0 AAA domain DUF2075 PF09848.9 CCF52649.1 - 0.046 12.9 0.1 0.3 10.3 0.0 2.0 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) cobW PF02492.19 CCF52649.1 - 0.052 13.1 2.1 6.5 6.3 0.4 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain NACHT PF05729.12 CCF52649.1 - 0.055 13.4 0.4 13 5.7 0.0 2.7 2 0 0 2 2 2 0 NACHT domain ATP_bind_1 PF03029.17 CCF52649.1 - 0.093 12.5 0.4 0.56 9.9 0.0 2.3 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein MobB PF03205.14 CCF52649.1 - 0.14 12.1 0.5 13 5.7 0.0 2.4 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B DEAD PF00270.29 CCF52649.1 - 0.18 11.6 0.1 11 5.7 0.0 2.5 2 0 0 2 2 2 0 DEAD/DEAH box helicase Dynamin_N PF00350.23 CCF52649.1 - 0.19 11.8 1.3 15 5.6 0.2 2.6 2 0 0 2 2 2 0 Dynamin family AAA_18 PF13238.6 CCF52649.1 - 0.27 11.8 1.5 3.1 8.4 0.1 2.7 2 0 0 2 2 2 0 AAA domain DUF4592 PF15262.6 CCF52649.1 - 4.8 7.9 6.0 2.8 8.6 0.7 2.8 3 0 0 3 3 2 0 Domain of unknown function (DUF4592) DUF2370 PF10176.9 CCF52650.1 - 9.6e-77 257.6 0.0 1.9e-76 256.6 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2370) TMEM252 PF15664.5 CCF52650.1 - 0.17 11.6 0.2 0.97 9.2 0.0 2.1 2 0 0 2 2 2 0 Transmembrane protein 252 family RINT1_TIP1 PF04437.13 CCF52651.1 - 6.9e-85 285.8 0.0 1.3e-84 284.9 0.0 1.4 1 0 0 1 1 1 1 RINT-1 / TIP-1 family DUF1690 PF07956.11 CCF52651.1 - 0.12 12.8 2.2 0.27 11.6 2.2 1.6 1 0 0 1 1 1 0 Protein of Unknown function (DUF1690) MWFE PF15879.5 CCF52652.1 - 1.9e-22 79.1 0.5 2.3e-22 78.9 0.5 1.1 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase MWFE subunit PQQ_3 PF13570.6 CCF52653.1 - 0.00047 20.6 0.4 2.8 8.6 0.0 3.8 3 0 0 3 3 3 1 PQQ-like domain WD40 PF00400.32 CCF52653.1 - 0.0068 17.2 7.8 11 7.1 0.1 5.7 7 0 0 7 7 7 2 WD domain, G-beta repeat VID27 PF08553.10 CCF52653.1 - 0.052 12.6 0.0 0.092 11.8 0.0 1.4 1 0 0 1 1 1 0 VID27 C-terminal WD40-like domain Pox_Ag35 PF03286.14 CCF52653.1 - 0.063 13.1 0.3 0.063 13.1 0.3 2.3 2 0 0 2 2 2 0 Pox virus Ag35 surface protein CCDC53 PF10152.9 CCF52653.1 - 0.37 11.2 4.6 8.9 6.7 0.2 2.7 3 0 0 3 3 3 0 Subunit CCDC53 of WASH complex RR_TM4-6 PF06459.12 CCF52653.1 - 1.4 8.7 8.3 3.1 7.5 0.3 2.1 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 DUF2201_N PF13203.6 CCF52653.1 - 5.4 6.5 8.5 0.5 9.9 1.8 2.0 2 0 0 2 2 2 0 Putative metallopeptidase domain PNISR PF15996.5 CCF52653.1 - 7.1 6.8 20.3 6.4 7.0 6.2 2.2 2 0 0 2 2 2 0 Arginine/serine-rich protein PNISR SH3_1 PF00018.28 CCF52654.1 - 3.9e-14 52.0 0.5 6.8e-14 51.2 0.5 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 CCF52654.1 - 7.1e-14 51.4 0.1 1.3e-13 50.6 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain PH PF00169.29 CCF52654.1 - 3.5e-12 46.8 0.0 7.1e-12 45.8 0.0 1.5 1 0 0 1 1 1 1 PH domain SH3_2 PF07653.17 CCF52654.1 - 3.2e-09 36.3 0.1 6.9e-09 35.3 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SAM_2 PF07647.17 CCF52654.1 - 1e-06 28.7 0.0 1.8e-06 27.9 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 CCF52654.1 - 1.3e-05 25.5 0.0 2.4e-05 24.7 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_Ste50p PF09235.10 CCF52654.1 - 0.01 16.0 0.2 0.019 15.2 0.2 1.4 1 0 0 1 1 1 0 Ste50p, sterile alpha motif tRNA_U5-meth_tr PF05958.11 CCF52656.1 - 3.1e-23 82.4 0.0 2.2e-21 76.3 0.0 2.9 2 1 0 2 2 2 1 tRNA (Uracil-5-)-methyltransferase Methyltransf_31 PF13847.6 CCF52656.1 - 2.2e-09 37.3 0.0 4.4e-09 36.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF52656.1 - 1.8e-06 28.5 0.0 4.4e-06 27.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_15 PF09445.10 CCF52656.1 - 1.1e-05 25.0 0.0 2.2e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase MTS PF05175.14 CCF52656.1 - 0.00022 20.8 0.0 0.00041 20.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_11 PF08241.12 CCF52656.1 - 0.00033 21.2 0.0 0.00092 19.8 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 CCF52656.1 - 0.0016 17.9 0.0 0.0027 17.2 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) TRAM PF01938.20 CCF52656.1 - 0.0065 16.4 0.0 0.015 15.3 0.0 1.7 1 0 0 1 1 1 1 TRAM domain Met_10 PF02475.16 CCF52656.1 - 0.0078 16.0 0.0 0.015 15.0 0.0 1.5 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_4 PF02390.17 CCF52656.1 - 0.0094 15.4 0.0 0.019 14.4 0.0 1.5 1 0 0 1 1 1 1 Putative methyltransferase TPMT PF05724.11 CCF52656.1 - 0.17 11.5 0.0 0.44 10.2 0.0 1.6 2 0 0 2 2 2 0 Thiopurine S-methyltransferase (TPMT) Ubie_methyltran PF01209.18 CCF52656.1 - 0.19 11.1 0.0 0.3 10.4 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family CENP-Q PF13094.6 CCF52657.1 - 9.5e-05 22.7 0.8 9.5e-05 22.7 0.8 1.6 2 0 0 2 2 2 1 CENP-Q, a CENPA-CAD centromere complex subunit DUF724 PF05266.14 CCF52657.1 - 0.71 9.7 3.7 1.1 9.1 3.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF724) FUSC PF04632.12 CCF52657.1 - 1.9 6.9 3.7 2.7 6.4 3.7 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family DUF4407 PF14362.6 CCF52657.1 - 2 7.7 5.9 2.6 7.3 5.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) SKN1 PF03935.15 CCF52658.1 - 2.1e-181 603.7 1.5 2.7e-181 603.4 1.5 1.0 1 0 0 1 1 1 1 Beta-glucan synthesis-associated protein (SKN1) Zn_clus PF00172.18 CCF52659.1 - 3.2e-08 33.5 11.7 6e-08 32.7 11.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Diphthamide_syn PF01866.17 CCF52660.1 - 4.1e-93 312.2 0.0 6.5e-53 180.1 0.0 4.0 2 1 0 2 2 2 2 Putative diphthamide synthesis protein IF4E PF01652.18 CCF52663.1 - 1e-49 168.4 0.0 1.6e-49 167.7 0.0 1.2 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E ADH_zinc_N PF00107.26 CCF52664.1 - 3.4e-24 85.3 0.1 3.6e-22 78.7 0.0 2.2 2 0 0 2 2 2 2 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CCF52664.1 - 2e-17 64.5 0.0 4.4e-17 63.4 0.0 1.6 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CCF52664.1 - 1.7e-09 37.5 0.1 4.4e-09 36.2 0.1 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain adh_short PF00106.25 CCF52664.1 - 0.0065 16.0 0.4 0.013 15.0 0.4 1.6 1 0 0 1 1 1 1 short chain dehydrogenase SIS_2 PF13580.6 CCF52664.1 - 0.081 12.9 0.1 0.25 11.4 0.0 1.9 2 0 0 2 2 2 0 SIS domain AMP-binding PF00501.28 CCF52665.1 - 1.8e-93 313.5 0.1 2.2e-93 313.2 0.1 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 CCF52665.1 - 6.6e-28 97.5 1.7 3.3e-26 92.1 0.1 2.6 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain ACAS_N PF16177.5 CCF52665.1 - 3.4e-16 58.9 0.4 9.6e-16 57.4 0.4 1.8 1 0 0 1 1 1 1 Acetyl-coenzyme A synthetase N-terminus Clp1 PF06807.14 CCF52666.1 - 1.3e-32 112.7 0.0 2.4e-32 111.8 0.0 1.5 1 0 0 1 1 1 1 Pre-mRNA cleavage complex II protein Clp1 CLP1_P PF16575.5 CCF52666.1 - 6.8e-26 91.2 0.0 3.9e-15 56.1 0.0 4.0 2 1 1 3 3 3 3 mRNA cleavage and polyadenylation factor CLP1 P-loop CLP1_N PF16573.5 CCF52666.1 - 9.2e-24 83.5 0.0 1.5e-23 82.8 0.0 1.4 1 0 0 1 1 1 1 N-terminal beta-sandwich domain of polyadenylation factor AAA_16 PF13191.6 CCF52666.1 - 0.0031 17.9 0.0 0.0073 16.7 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain NESP55 PF06390.12 CCF52666.1 - 0.012 15.2 1.5 0.02 14.5 1.5 1.2 1 0 0 1 1 1 0 Neuroendocrine-specific golgi protein P55 (NESP55) AAA_28 PF13521.6 CCF52666.1 - 0.016 15.4 0.1 0.048 13.9 0.0 1.9 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 CCF52666.1 - 0.038 14.1 0.1 5.7 7.1 0.0 2.4 2 0 0 2 2 2 0 50S ribosome-binding GTPase Dynamin_N PF00350.23 CCF52666.1 - 0.12 12.4 0.0 19 5.3 0.0 2.4 2 0 0 2 2 2 0 Dynamin family BRI3BP PF14965.6 CCF52666.1 - 0.22 11.0 0.0 0.38 10.3 0.0 1.3 1 0 0 1 1 1 0 Negative regulator of p53/TP53 ECH_2 PF16113.5 CCF52667.1 - 4.2e-87 292.8 0.1 1.4e-63 215.5 0.0 3.0 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase ECH_1 PF00378.20 CCF52667.1 - 4.6e-21 75.3 1.0 1.4e-11 44.2 0.1 2.8 2 1 1 3 3 3 2 Enoyl-CoA hydratase/isomerase DMRL_synthase PF00885.19 CCF52668.1 - 1.8e-49 167.2 0.0 2.2e-49 166.9 0.0 1.1 1 0 0 1 1 1 1 6,7-dimethyl-8-ribityllumazine synthase NAC PF01849.18 CCF52671.1 - 6.2e-22 77.3 0.0 1.1e-21 76.5 0.0 1.5 1 0 0 1 1 1 1 NAC domain ATP-synt_E PF05680.12 CCF52672.1 - 9.8e-20 70.7 0.3 1.1e-19 70.6 0.3 1.0 1 0 0 1 1 1 1 ATP synthase E chain Chordopox_A13L PF05961.11 CCF52672.1 - 0.097 12.9 0.1 0.15 12.3 0.1 1.2 1 0 0 1 1 1 0 Chordopoxvirus A13L protein WES_acyltransf PF03007.16 CCF52674.1 - 5.3e-17 62.4 0.0 9.1e-17 61.7 0.0 1.4 1 0 0 1 1 1 1 Wax ester synthase-like Acyl-CoA acyltransferase domain DUF1298 PF06974.13 CCF52674.1 - 1.8e-09 37.7 0.0 6.2e-09 35.9 0.0 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF1298) WD40 PF00400.32 CCF52675.1 - 9e-34 115.0 27.4 6.2e-08 33.2 0.2 7.7 8 0 0 8 8 8 5 WD domain, G-beta repeat TFIID_NTD2 PF04494.15 CCF52675.1 - 1e-26 93.7 0.0 2e-26 92.8 0.0 1.4 1 0 0 1 1 1 1 WD40 associated region in TFIID subunit, NTD2 domain ANAPC4_WD40 PF12894.7 CCF52675.1 - 3.9e-09 36.7 0.1 0.028 14.7 0.0 4.2 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CCF52675.1 - 0.057 12.4 0.2 5.1 6.0 0.0 3.4 2 1 1 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 CCF52675.1 - 0.069 12.5 0.0 10 5.3 0.0 2.8 2 1 1 3 3 3 0 WD40-like domain eIF2A PF08662.11 CCF52675.1 - 0.24 11.2 0.0 1.3 8.8 0.0 2.0 2 0 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A DASH_Spc19 PF08287.11 CCF52675.1 - 0.65 9.9 6.6 1.4 8.8 6.6 1.5 1 0 0 1 1 1 0 Spc19 TAF4 PF05236.14 CCF52675.1 - 0.82 9.4 12.7 0.017 14.9 5.5 1.8 2 0 0 2 2 2 0 Transcription initiation factor TFIID component TAF4 family Metallophos PF00149.28 CCF52676.1 - 1.1e-39 137.0 0.1 1.5e-39 136.6 0.1 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 CCF52676.1 - 1.1e-20 73.7 0.3 2.5e-20 72.6 0.1 1.7 2 0 0 2 2 2 1 Serine-threonine protein phosphatase N-terminal domain Pkinase PF00069.25 CCF52677.1 - 8e-36 123.7 0.0 1.4e-35 123.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF52677.1 - 6.3e-22 78.1 0.0 1.1e-21 77.3 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 CCF52677.1 - 0.033 13.6 0.0 0.06 12.7 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RRM_1 PF00076.22 CCF52678.1 - 4e-58 193.2 0.1 5.7e-19 67.7 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 CCF52678.1 - 3e-06 27.2 0.0 0.69 10.0 0.0 3.2 3 0 0 3 3 3 3 RNA binding motif RRM_occluded PF16842.5 CCF52678.1 - 9.6e-05 22.2 0.0 2 8.3 0.0 3.1 3 0 0 3 3 3 2 Occluded RNA-recognition motif Limkain-b1 PF11608.8 CCF52678.1 - 0.00016 21.7 0.1 3.1 7.9 0.0 3.7 3 1 0 3 3 3 2 Limkain b1 RRM_5 PF13893.6 CCF52678.1 - 0.00089 18.9 0.0 0.79 9.3 0.0 2.9 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SPOR PF05036.13 CCF52678.1 - 0.056 13.8 0.0 2.2 8.7 0.0 3.0 3 1 0 3 3 3 0 Sporulation related domain RRM_7 PF16367.5 CCF52678.1 - 0.06 13.5 0.0 34 4.6 0.0 3.3 4 0 0 4 4 4 0 RNA recognition motif YflT PF11181.8 CCF52678.1 - 0.072 13.6 0.0 1 9.9 0.0 2.5 2 0 0 2 2 2 0 Heat induced stress protein YflT ATP-grasp_2 PF08442.10 CCF52678.1 - 0.084 12.4 0.0 31 4.0 0.0 3.1 3 0 0 3 3 3 0 ATP-grasp domain RRM_Rrp7 PF17799.1 CCF52678.1 - 0.18 11.6 0.0 28 4.5 0.0 2.7 3 0 0 3 3 3 0 Rrp7 RRM-like N-terminal domain HAD PF12710.7 CCF52679.1 - 3.3e-21 76.5 0.0 4.3e-21 76.2 0.0 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase UMPH-1 PF05822.12 CCF52679.1 - 4.8e-09 36.1 0.0 8.3e-09 35.3 0.0 1.4 1 1 0 1 1 1 1 Pyrimidine 5'-nucleotidase (UMPH-1) Hydrolase PF00702.26 CCF52679.1 - 0.00025 21.4 0.7 0.011 16.1 0.0 2.7 1 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase Put_Phosphatase PF06888.12 CCF52679.1 - 0.00026 20.5 0.1 0.0014 18.1 0.1 1.9 2 0 0 2 2 2 1 Putative Phosphatase SpoU_sub_bind PF08032.12 CCF52679.1 - 0.17 12.2 0.0 2.3 8.5 0.0 2.5 2 1 0 2 2 2 0 RNA 2'-O ribose methyltransferase substrate binding Mem_trans PF03547.18 CCF52680.1 - 5.8e-36 123.7 5.0 1.7e-34 118.9 0.0 2.2 2 0 0 2 2 2 2 Membrane transport protein SBF PF01758.16 CCF52680.1 - 0.31 10.7 14.2 1.3 8.6 3.1 4.0 5 0 0 5 5 5 0 Sodium Bile acid symporter family Sod_Fe_C PF02777.18 CCF52681.1 - 1.8e-34 118.0 0.4 3.5e-34 117.0 0.1 1.6 2 0 0 2 2 2 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.22 CCF52681.1 - 4.1e-32 110.5 4.4 4.1e-32 110.5 4.4 1.9 2 0 0 2 2 2 1 Iron/manganese superoxide dismutases, alpha-hairpin domain CAS_C PF12026.8 CCF52681.1 - 0.046 13.8 0.1 0.077 13.1 0.1 1.3 1 0 0 1 1 1 0 Crk-Associated Substrate C-terminal domain N2227 PF07942.12 CCF52682.1 - 2.9e-92 308.7 0.0 3.5e-92 308.4 0.0 1.1 1 0 0 1 1 1 1 N2227-like protein DUF747 PF05346.11 CCF52683.1 - 3.9e-120 401.1 4.2 5.1e-120 400.8 4.2 1.1 1 0 0 1 1 1 1 Eukaryotic membrane protein family G-patch_2 PF12656.7 CCF52685.1 - 6.7e-23 80.6 3.5 1.1e-22 79.8 1.7 2.4 2 0 0 2 2 2 1 G-patch domain G-patch PF01585.23 CCF52685.1 - 7.9e-06 25.7 6.6 7.9e-06 25.7 6.6 2.3 2 0 0 2 2 2 1 G-patch domain AA_permease PF00324.21 CCF52686.1 - 3.1e-130 435.0 34.5 3.6e-130 434.8 34.5 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 CCF52686.1 - 8.8e-37 126.9 37.2 1.1e-36 126.6 37.2 1.1 1 0 0 1 1 1 1 Amino acid permease SID-1_RNA_chan PF13965.6 CCF52686.1 - 0.3 9.5 1.9 1.2 7.4 0.3 2.2 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 DUF3671 PF12420.8 CCF52686.1 - 7.7 6.6 7.5 4.5 7.4 0.5 3.2 2 1 0 2 2 2 0 Protein of unknown function Cupin_8 PF13621.6 CCF52687.1 - 1e-31 110.6 0.0 1.3e-31 110.3 0.0 1.1 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.12 CCF52687.1 - 5.7e-08 32.6 0.1 1.9e-07 30.9 0.1 1.7 1 1 0 1 1 1 1 Cupin superfamily protein JmjC PF02373.22 CCF52687.1 - 0.0016 18.8 0.0 0.021 15.2 0.0 2.5 2 1 0 2 2 2 1 JmjC domain, hydroxylase Cupin_1 PF00190.22 CCF52687.1 - 0.047 13.3 0.0 0.071 12.7 0.0 1.3 1 0 0 1 1 1 0 Cupin Cupin_2 PF07883.11 CCF52687.1 - 0.055 13.2 0.0 0.58 9.9 0.0 2.2 2 0 0 2 2 2 0 Cupin domain Aldo_ket_red PF00248.21 CCF52692.1 - 3.8e-42 144.5 0.0 1.1e-40 139.7 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family HU-CCDC81_euk_1 PF14908.6 CCF52692.1 - 0.14 12.3 0.0 1.2 9.4 0.0 2.1 2 0 0 2 2 2 0 CCDC81 eukaryotic HU domain 1 Hexokinase_2 PF03727.16 CCF52693.1 - 4.7e-79 265.2 0.0 7.3e-79 264.6 0.0 1.3 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 CCF52693.1 - 6.9e-64 215.4 0.0 1.1e-63 214.7 0.0 1.4 1 0 0 1 1 1 1 Hexokinase TTRAP PF14203.6 CCF52693.1 - 0.076 13.0 0.0 0.2 11.7 0.0 1.6 1 0 0 1 1 1 0 Putative tranposon-transfer assisting protein Amino_oxidase PF01593.24 CCF52694.1 - 2.1e-15 57.0 0.0 3e-15 56.5 0.0 1.2 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 CCF52694.1 - 1.7e-08 34.6 0.2 3.1e-08 33.7 0.2 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CCF52694.1 - 0.0083 15.4 0.1 0.11 11.7 0.1 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CCF52694.1 - 0.021 14.4 0.0 0.031 13.9 0.0 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 CCF52694.1 - 0.023 13.9 0.3 0.062 12.5 0.1 1.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CCF52694.1 - 0.13 12.2 0.3 0.86 9.6 0.1 2.5 3 0 0 3 3 3 0 FAD-NAD(P)-binding FAD_binding_3 PF01494.19 CCF52694.1 - 0.16 11.2 0.1 0.34 10.1 0.1 1.4 1 0 0 1 1 1 0 FAD binding domain Rad51 PF08423.11 CCF52695.1 - 6.1e-18 65.0 0.2 2.7e-12 46.5 0.0 3.5 4 0 0 4 4 4 3 Rad51 ATPase PF06745.13 CCF52695.1 - 0.00017 21.0 0.1 0.00029 20.3 0.1 1.3 1 0 0 1 1 1 1 KaiC RecA PF00154.21 CCF52695.1 - 0.0045 16.5 1.6 0.24 10.8 0.1 2.9 3 0 0 3 3 3 1 recA bacterial DNA recombination protein AAA_25 PF13481.6 CCF52695.1 - 0.029 14.0 0.1 0.33 10.5 0.0 2.5 2 0 0 2 2 2 0 AAA domain DnaB_C PF03796.15 CCF52695.1 - 0.066 12.5 0.0 0.91 8.8 0.0 2.1 2 0 0 2 2 2 0 DnaB-like helicase C terminal domain AAA_23 PF13476.6 CCF52695.1 - 0.078 13.5 0.0 0.15 12.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain Cse1 PF08506.10 CCF52696.1 - 4.4e-129 430.5 0.1 1.1e-128 429.1 0.1 1.7 2 0 0 2 2 2 1 Cse1 CAS_CSE1 PF03378.15 CCF52696.1 - 2.1e-116 389.1 0.0 5.5e-116 387.7 0.0 1.6 2 0 0 2 2 2 1 CAS/CSE protein, C-terminus IBN_N PF03810.19 CCF52696.1 - 6.9e-12 45.1 1.3 4e-11 42.7 1.1 2.6 2 0 0 2 2 2 1 Importin-beta N-terminal domain Xpo1 PF08389.12 CCF52696.1 - 0.00029 20.9 0.3 0.0057 16.7 0.0 3.4 3 0 0 3 3 3 1 Exportin 1-like protein CRISPR_Cse2 PF09485.10 CCF52696.1 - 0.069 13.7 0.1 6.8 7.2 0.0 3.3 3 0 0 3 3 3 0 CRISPR-associated protein Cse2 (CRISPR_cse2) rve PF00665.26 CCF52697.1 - 0.0015 18.7 0.1 0.0021 18.3 0.1 1.2 1 0 0 1 1 1 1 Integrase core domain NDUFA12 PF05071.16 CCF52698.1 - 9.8e-09 35.9 0.1 1.9e-08 35.0 0.1 1.6 1 1 0 1 1 1 1 NADH ubiquinone oxidoreductase subunit NDUFA12 TPR_1 PF00515.28 CCF52699.1 - 5.5e-10 38.6 3.0 0.038 13.8 0.3 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 CCF52699.1 - 3.1e-09 36.2 4.7 0.016 15.2 0.4 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_14 PF13428.6 CCF52699.1 - 7.7e-06 26.3 1.9 0.029 15.2 0.1 3.2 1 1 2 3 3 3 2 Tetratricopeptide repeat ANAPC3 PF12895.7 CCF52699.1 - 3.7e-05 23.9 5.0 7.9e-05 22.8 3.8 2.0 1 1 1 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 CCF52699.1 - 5.2e-05 23.7 3.8 0.0025 18.3 0.7 2.7 1 1 1 2 2 2 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 CCF52699.1 - 0.0014 18.6 0.9 0.0054 16.8 0.2 2.3 2 0 0 2 2 2 1 Fis1 C-terminal tetratricopeptide repeat TPR_12 PF13424.6 CCF52699.1 - 0.028 14.7 3.6 1.1 9.6 0.1 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_16 PF13432.6 CCF52699.1 - 0.038 14.6 9.8 0.067 13.9 0.5 3.1 4 0 0 4 4 3 0 Tetratricopeptide repeat MIT PF04212.18 CCF52699.1 - 0.078 13.0 3.6 0.38 10.8 0.8 2.6 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain TPR_11 PF13414.6 CCF52699.1 - 0.11 12.2 3.5 0.67 9.7 0.4 2.8 2 1 0 2 2 2 0 TPR repeat TPR_8 PF13181.6 CCF52699.1 - 0.12 12.6 2.1 8.1 6.9 0.6 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.6 CCF52699.1 - 0.34 11.0 3.2 13 6.1 0.1 3.0 3 0 0 3 3 2 0 Tetratricopeptide repeat BTAD PF03704.17 CCF52699.1 - 2.7 8.4 10.7 0.17 12.3 2.5 2.9 2 1 1 3 3 3 0 Bacterial transcriptional activator domain Spt20 PF12090.8 CCF52700.1 - 0.0046 16.6 1.9 0.019 14.6 1.9 2.1 1 0 0 1 1 1 1 Spt20 family GrpE PF01025.19 CCF52700.1 - 0.056 13.1 2.4 0.13 11.9 2.4 1.6 1 0 0 1 1 1 0 GrpE V_ATPase_I PF01496.19 CCF52700.1 - 9 4.1 14.6 1.7 6.5 6.3 2.3 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family DUF836 PF05768.14 CCF52701.1 - 1.9e-10 41.0 0.1 2.2e-10 40.8 0.1 1.1 1 0 0 1 1 1 1 Glutaredoxin-like domain (DUF836) ZapC PF07126.12 CCF52701.1 - 0.091 12.3 0.2 8.1 6.0 0.2 2.0 1 1 1 2 2 2 0 Cell-division protein ZapC AhpC-TSA PF00578.21 CCF52701.1 - 0.13 12.2 0.0 0.14 12.1 0.0 1.1 1 0 0 1 1 1 0 AhpC/TSA family Robl_LC7 PF03259.17 CCF52702.1 - 3.7e-07 29.8 0.1 5.8e-05 22.8 0.1 2.1 1 1 0 1 1 1 1 Roadblock/LC7 domain DUF2118 PF09891.9 CCF52702.1 - 0.22 11.5 0.0 0.28 11.1 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2118) ubiquitin PF00240.23 CCF52703.1 - 1.7e-06 27.7 0.0 1e-05 25.1 0.0 1.9 1 1 0 1 1 1 1 Ubiquitin family Ubiquitin_2 PF14560.6 CCF52703.1 - 5.6e-05 23.5 0.0 0.00026 21.4 0.0 1.8 1 1 0 1 1 1 1 Ubiquitin-like domain Rad60-SLD PF11976.8 CCF52703.1 - 0.08 12.8 0.0 0.31 10.9 0.0 1.8 1 1 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Arm PF00514.23 CCF52705.1 - 0.00019 21.4 0.4 0.0027 17.7 0.1 3.2 3 0 0 3 3 3 1 Armadillo/beta-catenin-like repeat SR-25 PF10500.9 CCF52705.1 - 5 6.7 5.6 8.5 5.9 0.1 2.6 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein LacAB_rpiB PF02502.18 CCF52706.1 - 1.1e-44 151.8 0.6 1.2e-44 151.7 0.6 1.0 1 0 0 1 1 1 1 Ribose/Galactose Isomerase DUF4514 PF14986.6 CCF52706.1 - 0.017 15.1 0.8 0.06 13.3 0.2 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF4514) TIM PF00121.18 CCF52707.1 - 1e-52 178.9 0.0 1.2e-52 178.7 0.0 1.1 1 0 0 1 1 1 1 Triosephosphate isomerase TFA2_Winged_2 PF18121.1 CCF52707.1 - 0.024 14.3 0.0 0.041 13.6 0.0 1.4 1 0 0 1 1 1 0 TFA2 Winged helix domain 2 TPR_2 PF07719.17 CCF52709.1 - 2.4e-07 30.3 4.7 0.69 10.2 0.0 4.0 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_14 PF13428.6 CCF52709.1 - 2.8e-06 27.7 11.6 0.14 13.0 1.8 4.9 3 2 2 5 5 5 3 Tetratricopeptide repeat TPR_19 PF14559.6 CCF52709.1 - 4.9e-06 27.0 6.2 0.69 10.5 0.5 4.3 2 1 2 4 4 4 3 Tetratricopeptide repeat TPR_16 PF13432.6 CCF52709.1 - 1e-05 26.0 3.0 0.0007 20.2 0.0 2.8 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 CCF52709.1 - 6.8e-05 22.5 0.6 2.6 8.0 0.0 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 CCF52709.1 - 0.005 16.5 0.8 1.8 8.3 0.1 3.1 3 0 0 3 3 3 1 TPR repeat TPR_17 PF13431.6 CCF52709.1 - 0.0061 16.9 0.3 7.3 7.2 0.0 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_9 PF13371.6 CCF52709.1 - 0.0067 16.6 4.5 2.1 8.6 0.2 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 CCF52709.1 - 0.082 13.2 2.6 21 5.7 0.2 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.6 CCF52709.1 - 0.26 11.6 7.5 5 7.5 0.2 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 CCF52709.1 - 0.76 10.5 4.6 7.9 7.4 0.0 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat PepSY_TM PF03929.16 CCF52710.1 - 0.13 11.9 0.1 0.29 10.8 0.0 1.7 2 0 0 2 2 2 0 PepSY-associated TM region LRR_6 PF13516.6 CCF52711.1 - 0.001 19.0 9.2 6 7.2 0.1 6.7 7 0 0 7 7 7 3 Leucine Rich repeat AMP-binding PF00501.28 CCF52712.1 - 9.6e-69 232.0 0.0 1.3e-68 231.5 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme NAD_binding_4 PF07993.12 CCF52712.1 - 4.2e-60 203.1 0.3 5.8e-56 189.5 0.0 2.5 2 1 0 2 2 2 2 Male sterility protein adh_short PF00106.25 CCF52712.1 - 1.7e-49 168.0 0.4 8.2e-49 165.7 0.6 2.2 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF52712.1 - 5.5e-38 130.8 0.3 2.8e-37 128.5 0.3 2.0 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF52712.1 - 3.6e-23 82.4 0.7 7.1e-19 68.4 0.5 2.4 2 0 0 2 2 2 2 KR domain Epimerase PF01370.21 CCF52712.1 - 4.7e-18 65.5 0.4 5.3e-09 35.9 0.0 3.3 3 1 0 3 3 3 2 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 CCF52712.1 - 1.4e-11 43.9 1.5 1.4e-05 24.2 0.0 3.1 3 0 0 3 3 3 2 3-beta hydroxysteroid dehydrogenase/isomerase family PP-binding PF00550.25 CCF52712.1 - 1.6e-08 34.8 0.0 3.7e-08 33.6 0.0 1.6 1 0 0 1 1 1 1 Phosphopantetheine attachment site Polysacc_synt_2 PF02719.15 CCF52712.1 - 1.9e-07 30.5 2.3 4.4e-05 22.7 0.1 3.0 2 1 0 2 2 2 2 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 CCF52712.1 - 3.9e-07 29.5 0.3 0.00027 20.1 0.0 3.1 2 1 0 2 2 2 2 RmlD substrate binding domain GDP_Man_Dehyd PF16363.5 CCF52712.1 - 8.5e-07 28.7 0.1 0.0021 17.5 0.1 2.3 2 0 0 2 2 2 2 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 CCF52712.1 - 0.00035 20.5 4.8 0.0079 16.1 2.9 3.8 3 1 0 3 3 3 1 NAD(P)H-binding AMP-binding_C PF13193.6 CCF52712.1 - 0.0052 17.7 1.2 0.016 16.1 0.1 2.5 3 0 0 3 3 1 1 AMP-binding enzyme C-terminal domain DFP PF04127.15 CCF52712.1 - 0.052 13.4 2.2 0.48 10.2 2.2 2.3 1 1 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein NAD_binding_2 PF03446.15 CCF52712.1 - 0.078 13.1 0.2 0.17 12.0 0.2 1.5 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase THF_DHG_CYH_C PF02882.19 CCF52712.1 - 0.11 11.8 0.0 0.25 10.7 0.0 1.5 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain ApbA PF02558.16 CCF52712.1 - 0.12 12.0 0.1 0.4 10.3 0.1 1.9 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Peroxidase_2 PF01328.17 CCF52713.1 - 1.2e-49 169.3 0.0 1.6e-49 169.0 0.0 1.1 1 0 0 1 1 1 1 Peroxidase, family 2 Transferase PF02458.15 CCF52714.1 - 1.7e-05 23.7 0.0 0.029 13.0 0.0 2.2 2 0 0 2 2 2 2 Transferase family MFS_1 PF07690.16 CCF52715.1 - 7.4e-37 127.1 53.0 1.6e-36 126.0 50.9 2.3 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF52715.1 - 1.2e-15 57.3 5.6 1.2e-15 57.3 5.6 2.4 2 1 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.13 CCF52715.1 - 8.1e-05 21.2 23.2 0.00011 20.9 23.2 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) UDPGT PF00201.18 CCF52717.1 - 0.0034 16.2 0.0 0.0075 15.1 0.0 1.5 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_transf_17 PF04724.13 CCF52719.1 - 2.9e-137 457.4 0.0 3.5e-137 457.1 0.0 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 17 Aldedh PF00171.22 CCF52720.1 - 8.3e-180 598.2 0.2 9.3e-180 598.0 0.2 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.14 CCF52720.1 - 0.014 14.5 0.0 0.022 13.8 0.0 1.2 1 0 0 1 1 1 0 Acyl-CoA reductase (LuxC) TRAM_LAG1_CLN8 PF03798.16 CCF52721.1 - 2e-07 30.9 13.1 3.1e-07 30.4 13.1 1.3 1 0 0 1 1 1 1 TLC domain Glyco_hydro_28 PF00295.17 CCF52722.1 - 1.1e-114 382.8 13.8 1.3e-114 382.7 13.8 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 28 RSN1_7TM PF02714.15 CCF52723.1 - 1.6e-72 244.1 11.2 1.6e-72 244.1 11.2 1.6 2 0 0 2 2 2 1 Calcium-dependent channel, 7TM region, putative phosphate PHM7_cyt PF14703.6 CCF52723.1 - 8.6e-41 140.1 0.6 1.3e-40 139.5 0.6 1.3 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter RSN1_TM PF13967.6 CCF52723.1 - 1.2e-36 125.8 5.0 1.2e-36 125.8 5.0 2.3 2 0 0 2 2 2 1 Late exocytosis, associated with Golgi transport PHM7_ext PF12621.8 CCF52723.1 - 1.1e-08 35.1 0.0 2.4e-08 34.0 0.0 1.5 1 0 0 1 1 1 1 Extracellular tail, of 10TM putative phosphate transporter DUF2892 PF11127.8 CCF52723.1 - 1.4 9.0 8.9 0.13 12.4 0.5 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2892) Cyclase PF04199.13 CCF52724.1 - 3.8e-13 49.9 0.1 1.8e-12 47.7 0.1 1.7 1 1 1 2 2 2 1 Putative cyclase PFK PF00365.20 CCF52725.1 - 2.9e-185 614.2 1.2 2.9e-88 295.9 0.3 3.3 3 0 0 3 3 3 3 Phosphofructokinase PapJ PF14855.6 CCF52725.1 - 0.029 14.1 0.0 0.057 13.1 0.0 1.4 1 0 0 1 1 1 0 Pilus-assembly fibrillin subunit, chaperone Pkinase PF00069.25 CCF52726.1 - 9.2e-53 179.3 0.0 5.7e-52 176.7 0.0 2.1 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF52726.1 - 2.5e-24 86.0 0.0 5.9e-24 84.7 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase Borrelia_P83 PF05262.11 CCF52726.1 - 2.3 6.6 6.5 3.5 6.0 6.5 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein HVSL PF09749.9 CCF52727.1 - 3.7e-35 121.5 0.0 4.4e-35 121.3 0.0 1.1 1 0 0 1 1 1 1 Uncharacterised conserved protein AAA_8 PF12780.7 CCF52727.1 - 0.099 11.9 0.0 0.15 11.4 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region D4 Ribosomal_S24e PF01282.19 CCF52728.1 - 8e-33 112.2 0.0 8e-33 112.2 0.0 1.5 2 0 0 2 2 2 1 Ribosomal protein S24e RRXRR PF14239.6 CCF52728.1 - 0.0028 17.5 2.9 0.0028 17.5 2.9 1.4 1 1 0 1 1 1 1 RRXRR protein MRP-L47 PF06984.13 CCF52729.1 - 1.5e-15 57.1 1.3 3.1e-15 56.1 1.3 1.5 1 0 0 1 1 1 1 Mitochondrial 39-S ribosomal protein L47 (MRP-L47) Ribosomal_L29 PF00831.23 CCF52729.1 - 0.0012 18.7 2.8 0.007 16.3 2.8 2.2 1 1 0 1 1 1 1 Ribosomal L29 protein G-alpha PF00503.20 CCF52730.1 - 2.9e-107 358.9 0.3 3.4e-107 358.7 0.3 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 CCF52730.1 - 6.1e-13 48.6 0.1 4.3e-08 32.8 0.1 2.4 2 0 0 2 2 2 2 ADP-ribosylation factor family Roc PF08477.13 CCF52730.1 - 0.027 14.7 0.0 4.5 7.5 0.0 2.4 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_29 PF13555.6 CCF52730.1 - 0.045 13.5 0.0 0.092 12.5 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Gtr1_RagA PF04670.12 CCF52730.1 - 0.064 12.6 0.2 6.7 6.0 0.0 2.2 2 0 0 2 2 2 0 Gtr1/RagA G protein conserved region DUF2985 PF11204.8 CCF52730.1 - 0.082 13.1 0.0 0.17 12.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2985) FtsK_SpoIIIE PF01580.18 CCF52730.1 - 0.11 11.8 0.0 0.19 11.0 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family Ribosomal_L37ae PF01780.19 CCF52731.1 - 4.4e-42 142.1 8.6 4.9e-42 141.9 8.6 1.0 1 0 0 1 1 1 1 Ribosomal L37ae protein family zf-RING_13 PF17977.1 CCF52731.1 - 0.00099 19.2 1.1 0.0014 18.8 1.1 1.2 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-BED PF02892.15 CCF52731.1 - 0.008 16.2 3.2 0.76 9.9 0.1 2.2 1 1 1 2 2 2 2 BED zinc finger Zn_Tnp_IS1595 PF12760.7 CCF52731.1 - 0.016 15.1 2.5 0.027 14.4 2.5 1.4 1 0 0 1 1 1 0 Transposase zinc-ribbon domain C1_2 PF03107.16 CCF52731.1 - 0.36 11.2 3.3 2 8.8 3.3 1.9 1 1 0 1 1 1 0 C1 domain zf-H2C2_2 PF13465.6 CCF52731.1 - 0.88 10.1 6.2 2.6 8.6 1.3 2.2 1 1 1 2 2 2 0 Zinc-finger double domain Alg6_Alg8 PF03155.15 CCF52732.1 - 4.7e-119 398.5 14.1 2.1e-91 307.3 6.1 2.1 2 0 0 2 2 2 2 ALG6, ALG8 glycosyltransferase family GCP_N_terminal PF17681.1 CCF52733.1 - 7.3e-24 84.9 0.0 1.1e-23 84.3 0.0 1.3 1 0 0 1 1 1 1 Gamma tubulin complex component N-terminal GCP_C_terminal PF04130.13 CCF52733.1 - 3.4e-23 82.6 0.0 6.7e-12 45.5 0.0 2.6 2 1 0 2 2 2 2 Gamma tubulin complex component C-terminal Abhydrolase_3 PF07859.13 CCF52734.1 - 9.4e-35 120.4 0.0 1.5e-34 119.7 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 CCF52734.1 - 6.2e-07 28.7 0.1 1.2e-06 27.7 0.0 1.4 2 0 0 2 2 2 1 Carboxylesterase family Abhydrolase_6 PF12697.7 CCF52734.1 - 0.00026 21.7 0.9 0.00086 20.0 0.9 1.9 1 1 0 1 1 1 1 Alpha/beta hydrolase family Esterase PF00756.20 CCF52734.1 - 0.012 15.2 0.2 0.03 14.0 0.0 1.8 2 1 0 2 2 2 0 Putative esterase Chlorophyllase2 PF12740.7 CCF52734.1 - 0.067 12.1 0.0 0.12 11.3 0.0 1.3 1 0 0 1 1 1 0 Chlorophyllase enzyme Chlorophyllase PF07224.11 CCF52734.1 - 0.14 11.2 0.2 0.79 8.7 0.0 1.9 2 0 0 2 2 2 0 Chlorophyllase Abhydrolase_2 PF02230.16 CCF52734.1 - 0.17 11.7 0.0 0.29 10.9 0.0 1.3 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase Glyco_hydro_45 PF02015.16 CCF52736.1 - 1.6e-67 227.5 14.5 2e-67 227.2 14.5 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 45 DUF1096 PF06493.11 CCF52736.1 - 2.1 8.8 7.7 7.1 7.2 3.3 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF1096) Nup192 PF11894.8 CCF52737.1 - 0 1220.1 0.0 0 1219.9 0.0 1.0 1 0 0 1 1 1 1 Nuclear pore complex scaffold, nucleoporins 186/192/205 RNase_P_Rpp14 PF01900.19 CCF52738.1 - 5.6e-23 81.1 0.0 7.9e-23 80.7 0.0 1.3 1 0 0 1 1 1 1 Rpp14/Pop5 family IBR PF01485.21 CCF52739.1 - 1.6e-18 66.7 37.0 5.6e-11 42.5 3.0 4.3 3 1 1 4 4 4 3 IBR domain, a half RING-finger domain RWD PF05773.22 CCF52739.1 - 3.2e-11 43.5 0.1 4e-09 36.8 0.0 2.4 2 0 0 2 2 2 1 RWD domain zf-RING_UBOX PF13445.6 CCF52739.1 - 2.3e-06 27.5 4.0 2.3e-06 27.5 4.0 3.8 3 0 0 3 3 3 1 RING-type zinc-finger zf-RING_2 PF13639.6 CCF52739.1 - 1.9e-05 24.9 6.2 1.9e-05 24.9 6.2 4.5 3 1 1 4 4 4 1 Ring finger domain zf-C3HC4 PF00097.25 CCF52739.1 - 2.5e-05 24.0 6.3 2.5e-05 24.0 6.3 4.4 3 1 1 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 CCF52739.1 - 9.5e-05 22.1 3.8 0.00025 20.7 3.8 1.8 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_5 PF14634.6 CCF52739.1 - 0.00025 20.9 7.6 0.00025 20.9 7.6 3.7 4 0 0 4 4 4 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 CCF52739.1 - 0.00039 20.2 3.8 0.00039 20.2 3.8 4.4 3 1 1 4 4 4 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 CCF52739.1 - 2.3 8.2 32.8 0.093 12.6 4.6 4.1 3 1 1 4 4 4 0 Prokaryotic RING finger family 4 FYVE_2 PF02318.16 CCF52739.1 - 5.7 7.2 15.5 0.2 11.9 3.1 3.2 3 0 0 3 3 3 0 FYVE-type zinc finger Glyco_transf_28 PF03033.20 CCF52740.1 - 3.3e-22 79.0 0.0 6.1e-22 78.2 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain GRAM PF02893.20 CCF52740.1 - 1.2e-07 31.6 0.0 0.0017 18.2 0.0 2.6 2 0 0 2 2 2 2 GRAM domain UDPGT PF00201.18 CCF52740.1 - 0.00065 18.6 0.0 0.0019 17.1 0.0 1.6 2 0 0 2 2 2 1 UDP-glucoronosyl and UDP-glucosyl transferase PH_BEACH PF14844.6 CCF52740.1 - 0.038 14.1 0.0 6.3 7.0 0.0 3.0 2 0 0 2 2 2 0 PH domain associated with Beige/BEACH RAB3GAP2_N PF14655.6 CCF52740.1 - 0.067 12.5 0.4 0.12 11.6 0.4 1.3 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus TPR_1 PF00515.28 CCF52741.1 - 4.1e-23 80.2 1.9 1.5e-07 30.9 0.0 5.0 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_2 PF07719.17 CCF52741.1 - 1.1e-20 72.1 10.2 4.3e-06 26.4 0.0 5.6 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_11 PF13414.6 CCF52741.1 - 1.1e-14 53.8 5.1 0.00035 20.2 0.0 4.3 2 1 2 4 4 4 3 TPR repeat TPR_8 PF13181.6 CCF52741.1 - 1.6e-14 52.8 5.8 0.004 17.3 0.0 5.8 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_14 PF13428.6 CCF52741.1 - 2.6e-11 43.4 12.2 0.0011 19.6 0.0 6.1 3 2 3 6 6 5 3 Tetratricopeptide repeat TPR_12 PF13424.6 CCF52741.1 - 3.6e-10 40.0 8.5 0.022 15.0 2.5 5.0 3 1 0 3 3 3 3 Tetratricopeptide repeat TPR_19 PF14559.6 CCF52741.1 - 4.6e-10 39.9 11.0 0.0071 16.8 1.4 4.3 3 2 1 4 4 3 3 Tetratricopeptide repeat TPR_17 PF13431.6 CCF52741.1 - 5e-09 35.9 4.4 0.0038 17.5 0.0 4.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 CCF52741.1 - 5.8e-09 36.5 12.6 3.4e-05 24.4 0.1 5.3 3 2 2 5 5 5 4 Tetratricopeptide repeat TPR_6 PF13174.6 CCF52741.1 - 2.7e-06 27.7 11.6 2.7 8.8 0.2 6.0 6 0 0 6 6 5 3 Tetratricopeptide repeat ANAPC3 PF12895.7 CCF52741.1 - 8.1e-05 22.8 2.9 0.0053 17.0 0.6 2.6 2 0 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_20 PF14561.6 CCF52741.1 - 0.0029 17.9 9.8 0.058 13.7 0.3 4.4 3 1 2 5 5 5 1 Tetratricopeptide repeat TPR_7 PF13176.6 CCF52741.1 - 0.0033 17.3 10.4 0.2 11.8 0.0 5.3 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_9 PF13371.6 CCF52741.1 - 0.0044 17.1 2.2 1.6 9.0 0.2 3.2 2 1 0 2 2 2 1 Tetratricopeptide repeat Sporozoite_P67 PF05642.11 CCF52741.1 - 0.02 13.0 4.6 0.029 12.5 4.6 1.3 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Coatomer_E PF04733.14 CCF52741.1 - 0.14 11.6 1.7 2.3 7.5 0.0 2.7 3 1 0 3 3 3 0 Coatomer epsilon subunit BTAD PF03704.17 CCF52741.1 - 0.21 12.0 11.8 1.4 9.3 2.9 3.9 4 0 0 4 4 4 0 Bacterial transcriptional activator domain TPR_10 PF13374.6 CCF52741.1 - 2.3 8.2 12.5 1.4 8.9 0.1 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat T3SS_needle_E PF08988.10 CCF52741.1 - 6 7.1 6.5 10 6.4 0.9 3.3 3 0 0 3 3 3 0 Type III secretion system, cytoplasmic E component of needle SHNi-TPR PF10516.9 CCF52741.1 - 6.8 6.2 6.2 56 3.3 0.2 3.8 4 0 0 4 4 4 0 SHNi-TPR SHNi-TPR PF10516.9 CCF52743.1 - 3.3e-13 48.8 0.0 8.6e-13 47.5 0.0 1.8 1 0 0 1 1 1 1 SHNi-TPR TPR_12 PF13424.6 CCF52743.1 - 0.00085 19.6 5.9 0.32 11.3 0.3 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat Milton PF12448.8 CCF52743.1 - 0.11 12.6 4.1 0.061 13.4 1.5 1.9 2 0 0 2 2 2 0 Kinesin associated protein TBCC_N PF16752.5 CCF52743.1 - 0.51 10.8 5.1 0.24 11.9 0.3 2.6 3 0 0 3 3 3 0 Tubulin-specific chaperone C N-terminal domain MscS_porin PF12795.7 CCF52743.1 - 8.1 5.9 12.8 0.21 11.1 1.4 3.4 3 1 1 4 4 4 0 Mechanosensitive ion channel porin domain Phosphodiest PF01663.22 CCF52744.1 - 1.9e-72 244.8 0.0 2.4e-72 244.5 0.0 1.1 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase DUF5622 PF18533.1 CCF52744.1 - 0.13 12.4 0.0 0.24 11.6 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5622) DLH PF01738.18 CCF52745.1 - 2.4e-24 86.1 0.1 4.5e-24 85.2 0.1 1.4 1 1 0 1 1 1 1 Dienelactone hydrolase family ODV-E18 PF10717.9 CCF52746.1 - 0.29 11.0 0.1 0.29 11.0 0.1 2.7 3 0 0 3 3 3 0 Occlusion-derived virus envelope protein ODV-E18 PIN_4 PF13638.6 CCF52747.1 - 1.2e-22 80.6 0.1 2.7e-22 79.5 0.0 1.7 2 0 0 2 2 2 1 PIN domain SUIM_assoc PF16619.5 CCF52747.1 - 0.48 10.5 8.5 0.062 13.4 3.7 2.0 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 ORC2 PF04084.14 CCF52748.1 - 1.1e-75 254.7 0.0 1.5e-75 254.2 0.0 1.1 1 0 0 1 1 1 1 Origin recognition complex subunit 2 VMA21 PF09446.10 CCF52749.1 - 7e-11 42.1 8.8 1.1e-10 41.4 8.8 1.3 1 1 0 1 1 1 1 VMA21-like domain CwfJ_C_1 PF04677.15 CCF52750.1 - 1.9e-15 56.8 0.0 4.2e-15 55.7 0.0 1.5 1 1 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 zf-CCHC_2 PF13696.6 CCF52750.1 - 1.3e-09 37.7 3.3 2.2e-09 37.0 3.3 1.4 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC PF00098.23 CCF52750.1 - 0.0012 18.9 0.5 0.0023 17.9 0.5 1.5 1 0 0 1 1 1 1 Zinc knuckle CwfJ_C_2 PF04676.14 CCF52750.1 - 0.0034 18.2 0.0 0.0034 18.2 0.0 1.8 2 0 0 2 2 2 1 Protein similar to CwfJ C-terminus 2 zf-CCHC_6 PF15288.6 CCF52750.1 - 0.15 11.9 0.3 1.3 8.9 0.2 2.4 2 0 0 2 2 2 0 Zinc knuckle RNA_pol_I_TF PF04090.12 CCF52751.1 - 0.036 13.5 0.1 0.13 11.7 0.1 1.8 1 1 1 2 2 2 0 RNA polymerase I specific initiation factor SelK_SelG PF10961.8 CCF52751.1 - 0.065 13.9 1.0 0.065 13.9 1.0 3.2 3 1 0 3 3 3 0 Selenoprotein SelK_SelG Cnd1 PF12717.7 CCF52752.1 - 2.2e-58 196.9 1.2 9.7e-51 172.0 0.1 4.0 4 0 0 4 4 4 2 non-SMC mitotic condensation complex subunit 1 Cnd1_N PF12922.7 CCF52752.1 - 1.7e-43 148.4 0.1 7.5e-43 146.3 0.0 2.3 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1, N-term HEAT PF02985.22 CCF52752.1 - 2.6e-09 36.5 3.8 2.3 8.7 0.0 7.8 8 0 0 8 8 7 2 HEAT repeat HEAT_2 PF13646.6 CCF52752.1 - 6.9e-08 32.8 1.0 0.026 14.9 0.0 5.4 4 1 1 5 5 5 2 HEAT repeats Cnd3 PF12719.7 CCF52752.1 - 5.6e-07 29.0 3.8 2.7e-06 26.8 0.5 2.9 3 0 0 3 3 3 1 Nuclear condensing complex subunits, C-term domain Adaptin_N PF01602.20 CCF52752.1 - 1.4e-06 27.2 1.4 0.001 17.7 0.9 3.4 2 1 0 2 2 2 2 Adaptin N terminal region RTP1_C1 PF10363.9 CCF52752.1 - 0.0035 17.5 0.2 14 5.9 0.0 4.2 3 1 1 4 4 4 0 Required for nuclear transport of RNA pol II C-terminus 1 Sigma70_ner PF04546.13 CCF52752.1 - 0.0052 16.7 3.6 0.0052 16.7 3.6 2.5 2 0 0 2 2 2 1 Sigma-70, non-essential region RRN3 PF05327.11 CCF52752.1 - 0.022 13.3 3.9 2.8 6.4 0.0 2.5 2 0 0 2 2 2 0 RNA polymerase I specific transcription initiation factor RRN3 FANCI_S2 PF14676.6 CCF52752.1 - 0.038 14.3 0.5 0.47 10.7 0.0 3.1 3 0 0 3 3 3 0 FANCI solenoid 2 HEAT_EZ PF13513.6 CCF52752.1 - 0.051 14.1 0.2 0.051 14.1 0.2 5.5 5 1 1 6 6 4 0 HEAT-like repeat DUF3357 PF11837.8 CCF52752.1 - 0.095 13.2 1.3 0.6 10.6 1.3 2.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3357) CDC45 PF02724.14 CCF52752.1 - 0.98 7.6 8.2 1.6 6.9 8.2 1.2 1 0 0 1 1 1 0 CDC45-like protein PqqD PF05402.12 CCF52752.1 - 3 8.2 5.0 37 4.7 0.0 4.2 4 0 0 4 4 4 0 Coenzyme PQQ synthesis protein D (PqqD) YL1 PF05764.13 CCF52752.1 - 4.2 7.4 12.6 1.4 9.0 7.3 2.4 2 0 0 2 2 2 0 YL1 nuclear protein DNA_pol_phi PF04931.13 CCF52752.1 - 8 4.4 24.2 5.9 4.9 0.0 2.7 3 0 0 3 3 3 0 DNA polymerase phi Sec62 PF03839.16 CCF52753.1 - 3.4e-52 177.1 2.4 6.9e-52 176.1 2.4 1.4 1 1 0 1 1 1 1 Translocation protein Sec62 DUF3413 PF11893.8 CCF52753.1 - 0.19 10.9 6.0 0.28 10.3 6.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3413) Glyco_hydro_43 PF04616.14 CCF52754.1 - 2.3e-06 27.2 0.6 3.4e-06 26.6 0.6 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 DUF5348 PF17295.2 CCF52754.1 - 0.086 12.8 0.3 0.85 9.6 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF5348) PX PF00787.24 CCF52755.1 - 1.8e-17 63.4 0.2 5.4e-17 61.8 0.2 1.9 1 1 0 1 1 1 1 PX domain BAR_3_WASP_bdg PF10456.9 CCF52755.1 - 1e-11 44.8 0.1 6.6e-11 42.1 0.1 2.0 2 0 0 2 2 2 1 WASP-binding domain of Sorting nexin protein SH3_1 PF00018.28 CCF52755.1 - 0.0028 17.2 0.0 0.0061 16.1 0.0 1.6 1 0 0 1 1 1 1 SH3 domain zf-C2H2 PF00096.26 CCF52756.1 - 0.00011 22.4 20.4 0.0074 16.7 7.5 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CCF52756.1 - 0.0072 17.1 17.1 0.49 11.4 3.9 3.1 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_6 PF13912.6 CCF52756.1 - 2.6 8.1 12.6 0.29 11.2 4.7 2.8 2 0 0 2 2 2 0 C2H2-type zinc finger Complex1_LYR PF05347.15 CCF52758.1 - 0.0041 17.1 0.7 0.014 15.4 0.7 2.0 1 0 0 1 1 1 1 Complex 1 protein (LYR family) LPP PF04728.13 CCF52758.1 - 0.067 13.6 0.3 0.29 11.6 0.3 2.1 1 0 0 1 1 1 0 Lipoprotein leucine-zipper ORC6 PF05460.13 CCF52759.1 - 0.00068 19.0 2.7 0.00068 19.0 2.7 2.3 2 0 0 2 2 2 1 Origin recognition complex subunit 6 (ORC6) Myc_N PF01056.18 CCF52759.1 - 0.12 12.3 4.8 0.15 11.9 1.2 2.2 2 0 0 2 2 2 0 Myc amino-terminal region Adeno_terminal PF02459.15 CCF52759.1 - 5.2 5.4 4.7 7.9 4.7 4.7 1.2 1 0 0 1 1 1 0 Adenoviral DNA terminal protein RRM_1 PF00076.22 CCF52760.1 - 1.7e-34 117.4 0.0 2.7e-18 65.5 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Ribosomal_S5_C PF03719.15 CCF52761.1 - 4.1e-19 67.8 0.0 1.7e-18 65.8 0.0 2.0 2 0 0 2 2 2 1 Ribosomal protein S5, C-terminal domain Ribosomal_S5 PF00333.20 CCF52761.1 - 3.3e-18 65.4 1.6 6e-18 64.6 1.6 1.5 1 0 0 1 1 1 1 Ribosomal protein S5, N-terminal domain BPS1 PF05633.11 CCF52761.1 - 3.3 6.6 10.4 7 5.5 10.4 1.4 1 0 0 1 1 1 0 Protein BYPASS1-related Sec8_exocyst PF04048.14 CCF52762.1 - 6.7e-40 136.3 0.2 1.5e-39 135.1 0.2 1.6 1 0 0 1 1 1 1 Sec8 exocyst complex component specific domain Vps54_N PF10475.9 CCF52762.1 - 0.00035 19.9 0.4 0.00073 18.9 0.4 1.4 1 0 0 1 1 1 1 Vacuolar-sorting protein 54, of GARP complex COG2 PF06148.11 CCF52762.1 - 0.056 13.5 1.9 0.2 11.7 0.2 2.7 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Methyltransf_16 PF10294.9 CCF52763.1 - 2.2e-17 63.4 0.0 5.4e-17 62.1 0.0 1.6 1 1 0 1 1 1 1 Lysine methyltransferase VPS13_mid_rpt PF16910.5 CCF52764.1 - 2.4e-91 305.3 12.4 4.8e-90 301.1 0.4 5.5 5 2 1 6 6 6 1 Repeating coiled region of VPS13 VPS13 PF16908.5 CCF52764.1 - 2e-83 279.8 0.7 1.6e-80 270.3 0.0 3.4 3 0 0 3 3 3 2 Vacuolar sorting-associated protein 13, N-terminal SHR-BD PF06650.12 CCF52764.1 - 1.8e-79 266.9 0.0 1.2e-75 254.3 0.0 3.1 2 1 1 3 3 3 3 SHR-binding domain of vacuolar-sorting associated protein 13 VPS13_C PF16909.5 CCF52764.1 - 8.1e-75 250.5 5.2 1.2e-69 233.7 0.4 2.8 2 0 0 2 2 2 2 Vacuolar-sorting-associated 13 protein C-terminal Chorein_N PF12624.7 CCF52764.1 - 5.4e-39 132.9 0.7 1.7e-38 131.3 0.1 2.3 2 0 0 2 2 2 1 N-terminal region of Chorein or VPS13 ATG_C PF09333.11 CCF52764.1 - 1e-08 35.4 0.0 1.8e-07 31.4 0.0 2.7 2 0 0 2 2 2 1 Autophagy-related protein C terminal domain BTG PF07742.12 CCF52765.1 - 2e-27 95.3 0.1 8.8e-27 93.3 0.0 2.1 2 0 0 2 2 2 1 BTG family zf-FPG_IleRS PF06827.14 CCF52765.1 - 0.028 14.3 0.7 0.057 13.3 0.7 1.6 1 0 0 1 1 1 0 Zinc finger found in FPG and IleRS Pol_alpha_B_N PF08418.10 CCF52766.1 - 7.1e-61 206.3 0.0 1e-60 205.8 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase alpha subunit B N-terminal DNA_pol_E_B PF04042.16 CCF52766.1 - 4.2e-22 78.5 0.0 6e-22 78.0 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B Tau95 PF09734.9 CCF52767.1 - 9.1e-37 127.0 0.2 1.6e-36 126.2 0.2 1.4 1 0 0 1 1 1 1 RNA polymerase III transcription factor (TF)IIIC subunit HTH domain Tau95_N PF17682.1 CCF52767.1 - 3.9e-29 101.4 0.0 6.9e-29 100.6 0.0 1.4 1 0 0 1 1 1 1 Tau95 Triple barrel domain MukE PF04288.13 CCF52767.1 - 0.0057 15.6 0.1 0.0093 14.9 0.1 1.3 1 0 0 1 1 1 1 MukE-like family Ran_BP1 PF00638.18 CCF52768.1 - 5.6e-52 175.2 1.6 8.2e-52 174.6 1.6 1.2 1 0 0 1 1 1 1 RanBP1 domain WH1 PF00568.23 CCF52768.1 - 8.6e-05 22.4 0.6 0.00044 20.2 0.6 1.9 1 1 0 1 1 1 1 WH1 domain DUF1681 PF07933.14 CCF52768.1 - 0.0011 18.7 0.6 0.0015 18.3 0.6 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1681) VID27_PH PF17747.1 CCF52768.1 - 0.0031 17.8 0.0 0.0046 17.2 0.0 1.2 1 0 0 1 1 1 1 VID27 PH-like domain EMP24_GP25L PF01105.24 CCF52769.1 - 2.1e-48 164.7 0.0 2.4e-48 164.5 0.0 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Apocytochr_F_C PF01333.19 CCF52769.1 - 0.055 13.5 0.0 1.5 8.9 0.0 2.3 2 0 0 2 2 2 0 Apocytochrome F, C-terminal DUF1229 PF06797.11 CCF52769.1 - 0.096 12.9 0.0 0.23 11.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1229) Nop PF01798.18 CCF52770.1 - 6.8e-86 287.5 0.2 1.5e-85 286.3 0.2 1.6 1 0 0 1 1 1 1 snoRNA binding domain, fibrillarin NOP5NT PF08156.13 CCF52770.1 - 5.5e-17 61.9 0.7 2.1e-16 60.1 0.7 2.1 1 0 0 1 1 1 1 NOP5NT (NUC127) domain CDC45 PF02724.14 CCF52770.1 - 0.41 8.9 12.5 8.6 4.5 11.1 2.2 2 0 0 2 2 2 0 CDC45-like protein AAA PF00004.29 CCF52771.1 - 3e-41 140.9 0.0 4.8e-41 140.3 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 CCF52771.1 - 2.4e-11 43.4 0.0 5.2e-11 42.3 0.0 1.6 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_lid_3 PF17862.1 CCF52771.1 - 2.5e-10 40.0 0.2 4.9e-10 39.0 0.2 1.5 1 0 0 1 1 1 1 AAA+ lid domain AAA_2 PF07724.14 CCF52771.1 - 1.7e-05 25.0 0.0 3.3e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) DUF815 PF05673.13 CCF52771.1 - 3.6e-05 23.0 0.0 8.3e-05 21.9 0.0 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_22 PF13401.6 CCF52771.1 - 4.3e-05 23.8 0.5 0.028 14.7 0.1 2.4 1 1 1 2 2 2 2 AAA domain AAA_16 PF13191.6 CCF52771.1 - 0.00026 21.4 0.4 0.0061 17.0 0.1 2.4 1 1 1 2 2 2 1 AAA ATPase domain AAA_5 PF07728.14 CCF52771.1 - 0.00041 20.4 0.3 0.0036 17.3 0.3 2.5 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 CCF52771.1 - 0.00091 19.0 0.0 0.0018 18.0 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_33 PF13671.6 CCF52771.1 - 0.0041 17.3 0.3 0.012 15.7 0.0 1.9 2 0 0 2 2 1 1 AAA domain ATPase PF06745.13 CCF52771.1 - 0.0043 16.4 0.0 0.17 11.2 0.0 2.4 1 1 1 2 2 2 1 KaiC AAA_18 PF13238.6 CCF52771.1 - 0.0043 17.6 0.1 0.013 16.0 0.0 1.9 2 0 0 2 2 1 1 AAA domain AAA_3 PF07726.11 CCF52771.1 - 0.0081 16.0 0.1 0.021 14.7 0.0 1.7 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_OB_N PF17758.1 CCF52771.1 - 0.0087 15.7 0.7 0.033 13.8 0.0 2.3 3 0 0 3 3 2 1 Proteasomal ATPase OB N-terminal domain AAA_14 PF13173.6 CCF52771.1 - 0.017 15.1 0.0 0.04 13.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 CCF52771.1 - 0.025 14.2 0.6 2.8 7.5 0.1 2.4 1 1 1 2 2 2 0 AAA domain IstB_IS21 PF01695.17 CCF52771.1 - 0.025 14.3 0.0 0.048 13.4 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_28 PF13521.6 CCF52771.1 - 0.042 14.1 0.4 0.099 12.9 0.0 1.8 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 CCF52771.1 - 0.072 13.5 0.0 0.14 12.5 0.0 1.5 1 0 0 1 1 1 0 RNA helicase TIP49 PF06068.13 CCF52771.1 - 0.079 12.1 0.0 0.14 11.3 0.0 1.4 1 0 0 1 1 1 0 TIP49 P-loop domain DUF2075 PF09848.9 CCF52771.1 - 0.11 11.7 0.0 0.16 11.2 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) NACHT PF05729.12 CCF52771.1 - 0.13 12.2 0.2 0.78 9.6 0.1 2.1 1 1 1 2 2 2 0 NACHT domain NB-ARC PF00931.22 CCF52771.1 - 0.13 11.5 0.0 0.62 9.2 0.0 2.0 2 0 0 2 2 2 0 NB-ARC domain Mg_chelatase PF01078.21 CCF52771.1 - 0.14 11.6 0.0 0.25 10.7 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_30 PF13604.6 CCF52771.1 - 0.18 11.5 0.4 0.46 10.2 0.4 1.7 1 1 0 1 1 1 0 AAA domain AAA_24 PF13479.6 CCF52771.1 - 0.36 10.5 2.4 0.38 10.5 0.3 2.0 2 1 0 2 2 2 0 AAA domain Tim17 PF02466.19 CCF52772.1 - 1.4e-33 115.5 8.0 1.7e-33 115.3 8.0 1.1 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family DUF543 PF04418.12 CCF52772.1 - 0.49 10.4 0.1 0.49 10.4 0.1 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF543) RRP7 PF12923.7 CCF52773.1 - 2.3e-27 95.5 0.0 2.3e-27 95.5 0.0 2.5 2 1 0 2 2 2 1 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain RRM_Rrp7 PF17799.1 CCF52773.1 - 1.6e-14 54.1 0.0 3.6e-14 52.9 0.0 1.6 1 1 0 1 1 1 1 Rrp7 RRM-like N-terminal domain RRM_1 PF00076.22 CCF52773.1 - 4.2e-06 26.5 0.0 1.5e-05 24.8 0.0 1.9 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CDC45 PF02724.14 CCF52773.1 - 0.048 11.9 3.5 0.061 11.6 3.5 1.2 1 0 0 1 1 1 0 CDC45-like protein DNA_pol_phi PF04931.13 CCF52773.1 - 0.89 7.6 8.6 1.2 7.1 8.6 1.1 1 0 0 1 1 1 0 DNA polymerase phi PBP1_TM PF14812.6 CCF52773.1 - 1.4 9.3 6.2 3.5 8.1 6.2 1.7 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Sporozoite_P67 PF05642.11 CCF52773.1 - 3.2 5.7 10.3 0.044 11.9 3.1 1.5 2 0 0 2 2 2 0 Sporozoite P67 surface antigen DGF-1_C PF11040.8 CCF52773.1 - 3.6 7.6 5.9 5.1 7.2 0.3 3.2 3 0 0 3 3 3 0 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus NOA36 PF06524.12 CCF52773.1 - 4.5 6.5 6.6 8.2 5.6 6.6 1.3 1 0 0 1 1 1 0 NOA36 protein Paf1 PF03985.13 CCF52773.1 - 4.7 6.1 11.6 8.5 5.2 11.6 1.3 1 0 0 1 1 1 0 Paf1 IMPDH PF00478.25 CCF52774.1 - 4e-133 443.7 0.2 9.7e-133 442.4 0.2 1.5 1 1 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain CBS PF00571.28 CCF52774.1 - 3.1e-17 62.8 0.0 7.3e-08 32.7 0.0 2.9 3 0 0 3 3 3 2 CBS domain NMO PF03060.15 CCF52774.1 - 2.9e-10 40.0 4.6 3.7e-08 33.1 3.6 2.3 2 0 0 2 2 2 2 Nitronate monooxygenase FMN_dh PF01070.18 CCF52774.1 - 2.1e-09 36.9 2.7 4.5e-09 35.8 1.9 1.9 2 0 0 2 2 2 1 FMN-dependent dehydrogenase His_biosynth PF00977.21 CCF52774.1 - 2.1e-07 30.6 3.5 1.4e-06 28.0 3.5 2.1 1 1 0 1 1 1 1 Histidine biosynthesis protein ThiG PF05690.14 CCF52774.1 - 0.00062 19.1 3.5 0.00079 18.8 2.2 1.8 1 1 0 1 1 1 1 Thiazole biosynthesis protein ThiG DUF561 PF04481.12 CCF52774.1 - 0.012 14.8 0.8 0.13 11.4 0.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF561) G3P_antiterm PF04309.12 CCF52774.1 - 0.015 14.7 1.9 0.15 11.5 0.3 2.4 2 0 0 2 2 2 0 Glycerol-3-phosphate responsive antiterminator Dus PF01207.17 CCF52774.1 - 0.045 12.8 2.3 0.29 10.2 0.1 2.2 2 0 0 2 2 2 0 Dihydrouridine synthase (Dus) QRPTase_C PF01729.19 CCF52774.1 - 0.11 12.3 0.7 0.59 9.9 0.1 2.3 2 1 1 3 3 3 0 Quinolinate phosphoribosyl transferase, C-terminal domain EAL PF00563.20 CCF52774.1 - 0.16 11.5 0.2 18 4.7 0.0 2.3 2 0 0 2 2 2 0 EAL domain DHO_dh PF01180.21 CCF52774.1 - 1.4 8.0 4.8 0.48 9.6 0.6 2.0 2 0 0 2 2 2 0 Dihydroorotate dehydrogenase RVT_2 PF07727.14 CCF52775.1 - 1.4e-57 195.1 0.1 9.3e-57 192.4 0.0 2.1 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 CCF52775.1 - 4.8e-06 26.8 0.0 1.5e-05 25.2 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain GvpL_GvpF PF06386.11 CCF52775.1 - 0.11 12.4 0.0 0.23 11.3 0.0 1.5 1 0 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF Hat1_N PF10394.9 CCF52777.1 - 5.7e-46 156.7 0.0 1.2e-45 155.6 0.0 1.6 2 0 0 2 2 2 1 Histone acetyl transferase HAT1 N-terminus MOZ_SAS PF01853.18 CCF52777.1 - 7.2e-06 25.8 0.2 1.4e-05 24.8 0.0 1.5 2 0 0 2 2 2 1 MOZ/SAS family Acetyltransf_1 PF00583.25 CCF52777.1 - 2e-05 24.8 0.0 4.2e-05 23.8 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CCF52777.1 - 0.0047 16.9 0.0 0.011 15.6 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Scm3 PF10384.9 CCF52777.1 - 0.035 13.8 0.0 0.08 12.7 0.0 1.6 1 0 0 1 1 1 0 Centromere protein Scm3 DUF4611 PF15387.6 CCF52777.1 - 0.082 13.1 0.5 0.17 12.1 0.5 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) ABC_membrane PF00664.23 CCF52778.1 - 2.1e-77 260.5 24.5 8.9e-39 133.8 8.8 2.3 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 CCF52778.1 - 6.5e-51 172.4 0.1 1e-31 110.3 0.1 3.0 2 1 0 2 2 2 2 ABC transporter MTABC_N PF16185.5 CCF52778.1 - 2.8e-09 36.8 0.2 7.7e-09 35.4 0.2 1.7 1 0 0 1 1 1 1 Mitochondrial ABC-transporter N-terminal five TM region SMC_N PF02463.19 CCF52778.1 - 3e-05 23.6 0.0 0.45 9.9 0.2 3.6 2 2 0 2 2 2 2 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 CCF52778.1 - 6.4e-05 23.0 0.2 0.14 12.2 0.0 2.8 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_16 PF13191.6 CCF52778.1 - 0.00059 20.3 4.2 0.061 13.7 0.4 3.0 2 1 1 3 3 3 2 AAA ATPase domain RsgA_GTPase PF03193.16 CCF52778.1 - 0.0024 17.8 0.3 2.5 8.0 0.1 2.5 2 0 0 2 2 2 2 RsgA GTPase DUF87 PF01935.17 CCF52778.1 - 0.005 17.0 1.0 0.96 9.5 0.1 2.9 2 0 0 2 2 2 1 Helicase HerA, central domain Dynamin_N PF00350.23 CCF52778.1 - 0.0056 16.8 3.8 0.12 12.4 0.1 3.0 3 0 0 3 3 3 1 Dynamin family AAA_29 PF13555.6 CCF52778.1 - 0.0095 15.7 0.8 5.5 6.8 0.1 2.9 2 0 0 2 2 2 2 P-loop containing region of AAA domain UPF0093 PF03653.13 CCF52778.1 - 0.043 14.0 0.1 0.2 11.9 0.1 2.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0093) IstB_IS21 PF01695.17 CCF52778.1 - 0.053 13.3 0.1 7.9 6.2 0.0 3.0 3 0 0 3 3 3 0 IstB-like ATP binding protein MpPF26 PF07666.11 CCF52778.1 - 0.64 10.1 3.9 0.31 11.1 0.4 2.3 2 0 0 2 2 2 0 M penetrans paralogue family 26 Chitin_synth_2 PF03142.15 CCF52779.1 - 7e-293 972.0 0.1 8.7e-293 971.7 0.1 1.1 1 0 0 1 1 1 1 Chitin synthase Glyco_trans_2_3 PF13632.6 CCF52779.1 - 2e-11 44.2 1.3 6.9e-11 42.4 1.3 2.0 1 1 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 CCF52779.1 - 2.2e-11 44.1 0.2 6.1e-11 42.6 0.0 1.9 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 CCF52779.1 - 4.2e-05 23.1 0.0 0.0048 16.4 0.0 2.3 2 0 0 2 2 2 2 Glycosyl transferase family 21 Glycos_transf_2 PF00535.26 CCF52779.1 - 0.0027 17.5 0.0 0.014 15.2 0.0 2.2 2 0 0 2 2 2 1 Glycosyl transferase family 2 Spt20 PF12090.8 CCF52779.1 - 1.2 8.6 20.1 2.3 7.8 20.1 1.4 1 0 0 1 1 1 0 Spt20 family EPL1 PF10513.9 CCF52779.1 - 6.9 7.0 8.0 14 6.1 8.0 1.5 1 0 0 1 1 1 0 Enhancer of polycomb-like Cpn60_TCP1 PF00118.24 CCF52780.1 - 5.4e-148 493.7 16.9 1.8e-147 492.0 16.9 1.6 1 1 0 1 1 1 1 TCP-1/cpn60 chaperonin family UFD1 PF03152.14 CCF52781.1 - 8e-68 227.3 0.0 1.1e-67 226.9 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 zf-RING_5 PF14634.6 CCF52782.1 - 2e-08 34.1 1.7 3.9e-08 33.1 1.7 1.5 1 0 0 1 1 1 1 zinc-RING finger domain Cast PF10174.9 CCF52782.1 - 0.00024 19.5 1.3 0.00036 18.9 1.3 1.2 1 0 0 1 1 1 1 RIM-binding protein of the cytomatrix active zone KLRAQ PF10205.9 CCF52782.1 - 0.00086 19.5 1.1 0.0017 18.6 1.1 1.4 1 0 0 1 1 1 1 Predicted coiled-coil domain-containing protein Churchill PF06573.11 CCF52782.1 - 0.0028 18.0 0.3 0.0049 17.2 0.3 1.4 1 0 0 1 1 1 1 Churchill protein Spc29 PF17082.5 CCF52782.1 - 0.027 14.3 1.7 0.052 13.4 1.7 1.5 1 0 0 1 1 1 0 Spindle Pole Component 29 SlyX PF04102.12 CCF52782.1 - 0.05 14.2 1.6 0.21 12.2 1.5 2.2 1 1 0 1 1 1 0 SlyX Occludin_ELL PF07303.13 CCF52782.1 - 0.31 11.8 2.5 0.74 10.6 2.5 1.6 1 0 0 1 1 1 0 Occludin homology domain zinc-ribbons_6 PF07191.12 CCF52782.1 - 1 9.4 3.5 7.5 6.6 3.5 2.2 1 1 0 1 1 1 0 zinc-ribbons zf-C3HC4_2 PF13923.6 CCF52782.1 - 5.3 7.0 8.0 28 4.7 2.6 2.9 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) JmjC PF02373.22 CCF52784.1 - 8.6e-08 32.6 0.0 2.9e-07 30.9 0.0 1.9 1 0 0 1 1 1 1 JmjC domain, hydroxylase FYVE PF01363.21 CCF52784.1 - 0.0096 16.0 3.8 0.032 14.4 3.8 1.9 1 0 0 1 1 1 1 FYVE zinc finger UPF0184 PF03670.13 CCF52784.1 - 0.088 13.2 0.7 0.32 11.4 0.7 2.0 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0184) ATP-synt_F6 PF05511.11 CCF52784.1 - 0.22 12.0 0.8 0.5 10.8 0.8 1.6 1 0 0 1 1 1 0 Mitochondrial ATP synthase coupling factor 6 Cupin_4 PF08007.12 CCF52784.1 - 0.35 10.3 5.8 2.6 7.4 2.8 2.7 3 0 0 3 3 3 0 Cupin superfamily protein zf-C3HC4_2 PF13923.6 CCF52784.1 - 0.45 10.4 7.3 1.1 9.2 7.3 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DUF3810 PF12725.7 CCF52784.1 - 1.3 8.3 3.0 2.2 7.5 3.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) zf-C3HC4 PF00097.25 CCF52784.1 - 2.2 8.2 8.1 6.6 6.7 8.1 1.8 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DUF4559 PF15112.6 CCF52784.1 - 5.9 6.5 10.6 2 8.0 7.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4559) ADH_zinc_N PF00107.26 CCF52785.1 - 1.5e-10 41.1 0.0 2.7e-10 40.3 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CCF52785.1 - 3.3e-06 27.0 0.0 1e-05 25.4 0.0 1.8 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 CCF52785.1 - 0.018 16.1 0.0 0.058 14.4 0.0 1.9 1 1 1 2 2 2 0 Zinc-binding dehydrogenase GHMP_kinases_C PF08544.13 CCF52785.1 - 0.11 12.9 0.0 0.31 11.4 0.0 1.7 2 0 0 2 2 2 0 GHMP kinases C terminal Sterol-sensing PF12349.8 CCF52786.1 - 2.9e-48 163.6 10.9 5e-48 162.8 10.9 1.3 1 0 0 1 1 1 1 Sterol-sensing domain of SREBP cleavage-activation Patched PF02460.18 CCF52786.1 - 1.6e-13 49.7 6.9 2.2e-13 49.2 6.9 1.1 1 0 0 1 1 1 1 Patched family ANAPC4_WD40 PF12894.7 CCF52786.1 - 0.0007 19.9 0.1 3.8 7.9 0.0 3.3 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 CCF52786.1 - 0.00091 20.0 0.1 0.62 11.0 0.0 3.6 2 0 0 2 2 2 1 WD domain, G-beta repeat 6PGD PF00393.19 CCF52787.1 - 9.6e-127 422.3 0.0 1.2e-126 422.0 0.0 1.1 1 0 0 1 1 1 1 6-phosphogluconate dehydrogenase, C-terminal domain NAD_binding_2 PF03446.15 CCF52787.1 - 2.1e-52 177.5 0.0 3e-52 177.0 0.0 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 CCF52787.1 - 0.017 15.7 0.1 0.033 14.8 0.1 1.5 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent NAD_binding_11 PF14833.6 CCF52787.1 - 0.081 13.2 0.0 0.2 11.9 0.0 1.6 1 0 0 1 1 1 0 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase Ub-Mut7C PF14451.6 CCF52787.1 - 0.19 11.6 0.0 0.48 10.3 0.0 1.7 1 0 0 1 1 1 0 Mut7-C ubiquitin CoatB PF10389.9 CCF52787.1 - 0.23 11.3 1.8 0.88 9.5 0.2 2.2 2 0 0 2 2 2 0 Bacteriophage coat protein B Het-C PF07217.11 CCF52788.1 - 1.4e-217 723.7 0.0 3.3e-217 722.5 0.0 1.6 1 1 0 1 1 1 1 Heterokaryon incompatibility protein Het-C RPA_C PF08784.11 CCF52789.1 - 1.6e-17 64.1 2.3 2.1e-17 63.7 0.5 2.1 2 0 0 2 2 2 1 Replication protein A C terminal tRNA_anti-codon PF01336.25 CCF52789.1 - 9.3e-09 35.2 0.5 1.5e-08 34.5 0.5 1.3 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain RMI2 PF16100.5 CCF52789.1 - 0.018 14.8 0.1 0.038 13.8 0.1 1.5 1 0 0 1 1 1 0 RecQ-mediated genome instability protein 2 Methyltransf_16 PF10294.9 CCF52790.1 - 5.2e-15 55.6 0.1 4.2e-14 52.7 0.1 2.1 1 1 0 1 1 1 1 Lysine methyltransferase MTS PF05175.14 CCF52790.1 - 0.052 13.1 0.1 0.11 12.0 0.0 1.5 2 0 0 2 2 2 0 Methyltransferase small domain FAM86 PF14904.6 CCF52790.1 - 0.053 13.6 0.0 0.11 12.6 0.0 1.5 1 0 0 1 1 1 0 Family of unknown function E1-E2_ATPase PF00122.20 CCF52792.1 - 1.1e-41 142.3 0.6 2.1e-38 131.7 0.0 3.5 3 1 0 3 3 3 2 E1-E2 ATPase Hydrolase PF00702.26 CCF52792.1 - 6.3e-19 69.1 0.4 1.3e-18 68.0 0.4 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 CCF52792.1 - 9.3e-08 31.7 0.0 1.9e-07 30.7 0.0 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 CCF52792.1 - 0.0018 18.1 0.3 0.0039 17.0 0.1 1.6 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase YrvL PF14184.6 CCF52792.1 - 0.0033 17.5 4.4 0.0033 17.5 4.4 2.4 2 0 0 2 2 2 1 Regulatory protein YrvL Cation_ATPase PF13246.6 CCF52792.1 - 0.027 14.5 0.0 0.06 13.4 0.0 1.6 1 0 0 1 1 1 0 Cation transport ATPase (P-type) PLU-1 PF08429.11 CCF52793.1 - 1.7e-92 310.2 2.4 9.2e-91 304.5 1.7 2.5 2 0 0 2 2 2 1 PLU-1-like protein JmjC PF02373.22 CCF52793.1 - 8.1e-43 145.5 0.4 1.7e-42 144.4 0.4 1.6 1 0 0 1 1 1 1 JmjC domain, hydroxylase PHD PF00628.29 CCF52793.1 - 2.8e-24 84.8 37.6 3e-12 46.2 3.3 4.4 4 0 0 4 4 4 3 PHD-finger ARID PF01388.21 CCF52793.1 - 8.6e-17 61.6 0.0 2e-16 60.4 0.0 1.7 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain JmjN PF02375.17 CCF52793.1 - 4e-15 55.5 1.1 9.3e-15 54.3 1.1 1.7 1 0 0 1 1 1 1 jmjN domain zf-C5HC2 PF02928.16 CCF52793.1 - 1.2e-10 41.6 0.2 1.2e-10 41.6 0.2 2.7 4 0 0 4 4 2 1 C5HC2 zinc finger zf-HC5HC2H PF13771.6 CCF52793.1 - 0.0029 17.8 13.8 1.3 9.3 0.8 3.6 3 0 0 3 3 3 3 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.6 CCF52793.1 - 0.099 12.8 10.5 3.1 8.0 0.5 3.5 3 0 0 3 3 3 0 PHD-zinc-finger like domain TusA PF01206.17 CCF52793.1 - 0.12 12.3 0.4 0.44 10.4 0.1 2.2 2 0 0 2 2 2 0 Sulfurtransferase TusA PHD_2 PF13831.6 CCF52793.1 - 0.22 11.1 26.1 0.042 13.4 4.1 3.8 4 0 0 4 4 4 0 PHD-finger C1_1 PF00130.22 CCF52793.1 - 6.4 6.8 24.0 1.3 8.9 0.5 4.3 4 0 0 4 4 4 0 Phorbol esters/diacylglycerol binding domain (C1 domain) AMP-binding PF00501.28 CCF52794.1 - 1.1e-71 241.7 0.0 1.3e-71 241.4 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 CCF52794.1 - 0.00091 20.2 0.2 0.0058 17.6 0.1 2.3 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain YqaJ PF09588.10 CCF52794.1 - 0.2 11.8 0.0 2.4 8.3 0.0 2.2 2 0 0 2 2 2 0 YqaJ-like viral recombinase domain MFS_1 PF07690.16 CCF52796.1 - 2.1e-29 102.6 26.9 2.1e-29 102.6 26.9 1.8 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF52796.1 - 1.2e-11 44.1 4.1 1.2e-11 44.1 4.1 2.1 3 0 0 3 3 3 1 Sugar (and other) transporter Phage_Gp23 PF10669.9 CCF52796.1 - 0.67 10.3 0.0 0.67 10.3 0.0 2.0 2 0 0 2 2 2 0 Protein gp23 (Bacteriophage A118) CLPTM1 PF05602.12 CCF52797.1 - 5.8e-122 407.8 0.0 2.1e-118 396.1 0.0 2.2 2 0 0 2 2 2 2 Cleft lip and palate transmembrane protein 1 (CLPTM1) PQ-loop PF04193.14 CCF52797.1 - 1.2e-05 25.0 0.4 1.2e-05 25.0 0.4 2.3 3 0 0 3 3 3 1 PQ loop repeat zf-MYND PF01753.18 CCF52798.1 - 5.1e-06 26.5 15.8 5.1e-06 26.5 15.8 2.5 2 0 0 2 2 2 1 MYND finger Cyclin_N PF00134.23 CCF52799.1 - 4.8e-45 152.4 0.2 7.8e-42 142.0 0.4 2.3 2 0 0 2 2 2 2 Cyclin, N-terminal domain Cyclin_C PF02984.19 CCF52799.1 - 1.8e-26 92.6 0.0 1.8e-26 92.6 0.0 1.8 2 0 0 2 2 2 1 Cyclin, C-terminal domain Rad21_Rec8_N PF04825.13 CCF52801.1 - 1.3e-38 131.5 0.2 2.8e-38 130.5 0.2 1.5 1 0 0 1 1 1 1 N terminus of Rad21 / Rec8 like protein Rad21_Rec8 PF04824.16 CCF52801.1 - 3.2e-16 58.3 0.0 9.9e-16 56.8 0.0 1.9 1 0 0 1 1 1 1 Conserved region of Rad21 / Rec8 like protein NAD_binding_2 PF03446.15 CCF52802.1 - 9.4e-17 61.6 0.0 1.5e-16 60.9 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 CCF52802.1 - 1.7e-10 41.2 0.0 3.3e-10 40.3 0.0 1.4 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase Shikimate_DH PF01488.20 CCF52802.1 - 1.7e-06 28.2 0.0 3e-06 27.3 0.0 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase F420_oxidored PF03807.17 CCF52802.1 - 0.00026 21.5 0.0 0.0011 19.4 0.0 2.1 2 1 1 3 3 3 1 NADP oxidoreductase coenzyme F420-dependent F-box-like PF12937.7 CCF52803.1 - 5.1e-12 45.5 1.3 5.1e-12 45.5 1.3 2.7 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 CCF52803.1 - 8.7e-08 31.9 0.3 8.7e-08 31.9 0.3 2.1 2 0 0 2 2 2 1 F-box domain ANAPC4_WD40 PF12894.7 CCF52803.1 - 0.014 15.7 0.0 7.6 6.9 0.0 2.5 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain F-box_4 PF15966.5 CCF52803.1 - 0.028 14.3 0.0 0.066 13.1 0.0 1.6 1 0 0 1 1 1 0 F-box ATP_synt_H PF05493.13 CCF52804.1 - 2.7e-21 75.8 3.3 3.2e-21 75.6 3.3 1.0 1 0 0 1 1 1 1 ATP synthase subunit H DUF2749 PF10907.8 CCF52804.1 - 8.2 6.7 6.1 2.9 8.1 1.2 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2749) Syja_N PF02383.18 CCF52805.1 - 2.4e-71 240.7 0.0 3.4e-71 240.2 0.0 1.2 1 0 0 1 1 1 1 SacI homology domain Exo_endo_phos PF03372.23 CCF52805.1 - 4.6e-10 39.4 0.0 1.2e-09 38.0 0.0 1.8 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Asp PF00026.23 CCF52808.1 - 1.1e-61 209.1 0.1 1.5e-61 208.6 0.1 1.2 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 CCF52808.1 - 5.7e-10 39.7 0.3 0.0012 19.1 0.0 2.6 1 1 1 2 2 2 2 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 CCF52808.1 - 0.00027 21.5 2.2 0.15 12.7 0.0 3.6 3 1 0 3 3 3 2 Aspartyl protease gag-asp_proteas PF13975.6 CCF52808.1 - 0.00045 20.7 1.1 0.28 11.7 0.0 3.5 3 0 0 3 3 3 2 gag-polyprotein putative aspartyl protease MFS_1 PF07690.16 CCF52809.1 - 1.3e-35 123.0 50.7 1e-34 120.1 50.7 2.1 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF52809.1 - 1.4e-11 43.9 12.5 1.4e-11 43.9 12.5 3.1 2 1 0 3 3 3 1 Sugar (and other) transporter Hydrolase_4 PF12146.8 CCF52810.1 - 1.3e-19 70.5 0.0 2.7e-19 69.4 0.0 1.4 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 CCF52810.1 - 5.3e-07 30.5 0.3 7.4e-07 30.0 0.3 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 CCF52810.1 - 0.0017 18.1 0.1 0.0041 16.8 0.1 1.6 1 0 0 1 1 1 1 alpha/beta hydrolase fold DLH PF01738.18 CCF52810.1 - 0.042 13.4 0.0 2.4 7.6 0.0 2.2 2 0 0 2 2 2 0 Dienelactone hydrolase family Rhomboid_SP PF12595.8 CCF52810.1 - 0.078 12.3 0.2 0.12 11.7 0.2 1.2 1 0 0 1 1 1 0 Rhomboid serine protease Peptidase_M16_C PF05193.21 CCF52811.1 - 1.1e-45 155.9 0.0 1.6e-45 155.3 0.0 1.3 1 0 0 1 1 1 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 CCF52811.1 - 7.1e-42 142.9 0.0 1.5e-41 141.9 0.0 1.5 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) TRPM_tetra PF16519.5 CCF52811.1 - 0.057 13.5 1.7 11 6.2 0.2 2.8 2 0 0 2 2 2 0 Tetramerisation domain of TRPM Peptidase_S64 PF08192.11 CCF52811.1 - 0.75 8.2 7.7 1.3 7.5 7.7 1.3 1 0 0 1 1 1 0 Peptidase family S64 Apt1 PF10351.9 CCF52811.1 - 9.4 5.0 11.5 0.57 9.0 5.3 1.9 2 0 0 2 2 2 0 Golgi-body localisation protein domain Zn_clus PF00172.18 CCF52812.1 - 3e-08 33.6 7.7 4.9e-08 33.0 7.7 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 CCF52812.1 - 6.2e-08 32.0 0.1 1.6e-06 27.3 0.0 2.4 2 1 0 2 2 2 1 Fungal specific transcription factor domain HMMR_N PF15905.5 CCF52813.1 - 0.00046 19.8 146.0 0.0025 17.4 14.7 7.3 3 1 4 7 7 7 7 Hyaluronan mediated motility receptor N-terminal Tropomyosin PF00261.20 CCF52813.1 - 0.0013 18.1 10.9 0.0013 18.1 10.9 9.9 3 3 4 7 7 7 1 Tropomyosin Cep57_CLD_2 PF14197.6 CCF52813.1 - 0.0042 17.1 4.7 0.0042 17.1 4.7 12.0 7 2 3 11 11 11 1 Centrosome localisation domain of PPC89 Mto2_bdg PF12808.7 CCF52813.1 - 0.006 16.9 11.2 0.006 16.9 11.2 9.8 10 2 1 11 11 11 1 Micro-tubular organiser Mto1 C-term Mto2-binding region APG6_N PF17675.1 CCF52813.1 - 0.0085 16.6 28.7 0.0085 16.6 28.7 13.4 3 3 6 10 10 10 2 Apg6 coiled-coil region ATG16 PF08614.11 CCF52813.1 - 0.0093 16.2 34.0 0.0093 16.2 34.0 11.3 1 1 8 9 9 9 4 Autophagy protein 16 (ATG16) PHD PF00628.29 CCF52815.1 - 5.8e-07 29.3 10.6 9.8e-07 28.6 10.6 1.3 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 CCF52815.1 - 0.0012 18.4 7.0 0.0023 17.5 7.0 1.4 1 0 0 1 1 1 1 PHD-finger zf-CW PF07496.15 CCF52815.1 - 0.014 15.4 5.0 0.028 14.5 5.0 1.5 1 0 0 1 1 1 0 CW-type Zinc Finger Telomere_reg-2 PF10193.9 CCF52816.1 - 2e-24 86.1 0.0 6.1e-24 84.6 0.0 1.9 1 0 0 1 1 1 1 Telomere length regulation protein SNF2_N PF00176.23 CCF52817.1 - 1.1e-75 254.5 0.1 3e-75 253.1 0.1 1.6 1 1 0 1 1 1 1 SNF2 family N-terminal domain SLIDE PF09111.10 CCF52817.1 - 1.5e-39 134.5 0.3 1.5e-39 134.5 0.3 3.0 5 0 0 5 5 4 1 SLIDE HAND PF09110.11 CCF52817.1 - 1.5e-33 115.9 3.0 1.5e-33 115.9 3.0 4.2 4 0 0 4 4 4 1 HAND Helicase_C PF00271.31 CCF52817.1 - 1e-20 74.1 0.0 1.1e-18 67.6 0.0 3.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CCF52817.1 - 1.1e-10 41.8 0.8 8e-10 39.0 0.0 2.8 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit Myb_DNA-binding PF00249.31 CCF52817.1 - 2.8e-06 27.4 2.1 0.00098 19.3 0.0 3.1 3 0 0 3 3 2 2 Myb-like DNA-binding domain DEAD PF00270.29 CCF52817.1 - 7.3e-06 25.9 0.0 2.5e-05 24.1 0.0 2.0 1 0 0 1 1 1 1 DEAD/DEAH box helicase HDA2-3 PF11496.8 CCF52817.1 - 0.00012 21.4 0.6 0.00032 20.0 0.0 2.0 2 0 0 2 2 2 1 Class II histone deacetylase complex subunits 2 and 3 DBINO PF13892.6 CCF52817.1 - 0.0021 18.4 8.3 0.0021 18.4 8.3 4.2 2 2 2 4 4 3 1 DNA-binding domain DUF1086 PF06461.11 CCF52817.1 - 0.0033 17.3 0.9 0.018 14.9 0.1 2.3 2 0 0 2 2 2 1 Domain of Unknown Function (DUF1086) ERCC3_RAD25_C PF16203.5 CCF52817.1 - 0.01 15.0 0.2 0.01 15.0 0.2 2.7 2 1 0 2 2 2 0 ERCC3/RAD25/XPB C-terminal helicase AAA_14 PF13173.6 CCF52817.1 - 0.014 15.4 0.3 0.066 13.2 0.0 2.3 2 0 0 2 2 2 0 AAA domain DUF3847 PF12958.7 CCF52817.1 - 0.014 15.5 1.0 0.014 15.5 1.0 3.2 3 0 0 3 3 2 0 Protein of unknown function (DUF3847) THF_DHG_CYH PF00763.23 CCF52818.1 - 1.4e-26 93.0 0.0 2.6e-26 92.2 0.0 1.5 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain THF_DHG_CYH_C PF02882.19 CCF52818.1 - 3.5e-15 55.7 0.0 4.8e-08 32.5 0.0 2.7 2 1 0 2 2 2 2 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Shikimate_DH PF01488.20 CCF52818.1 - 0.067 13.2 0.0 0.43 10.6 0.0 2.0 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase SprA-related PF12118.8 CCF52819.1 - 0.0058 15.8 9.1 0.011 14.9 9.2 1.4 1 1 0 1 1 1 1 SprA-related family Nucleo_P87 PF07267.11 CCF52819.1 - 0.095 11.5 2.5 0.14 11.0 2.5 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 Shisa PF13908.6 CCF52819.1 - 2.8 8.2 7.1 5.4 7.2 7.1 1.6 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator NAM-associated PF14303.6 CCF52819.1 - 4.5 8.0 14.6 0.63 10.7 9.6 1.9 1 1 1 2 2 2 0 No apical meristem-associated C-terminal domain Neil1-DNA_bind PF09292.10 CCF52820.1 - 0.0079 16.1 0.0 0.019 14.9 0.0 1.6 1 0 0 1 1 1 1 Endonuclease VIII-like 1, DNA bind SMP PF04927.12 CCF52821.1 - 0.35 11.4 2.4 0.63 10.6 2.4 1.4 1 0 0 1 1 1 0 Seed maturation protein RRM_1 PF00076.22 CCF52823.1 - 2.9e-15 55.8 0.0 4e-15 55.4 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 CCF52823.1 - 2.9e-06 26.9 0.0 3.3e-06 26.7 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_8 PF11835.8 CCF52823.1 - 0.0043 17.2 0.0 0.006 16.8 0.0 1.2 1 0 0 1 1 1 1 RRM-like domain RRM_3 PF08777.11 CCF52823.1 - 0.11 12.6 0.0 0.16 12.0 0.0 1.2 1 0 0 1 1 1 0 RNA binding motif GST_C_2 PF13410.6 CCF52824.1 - 3.4e-09 36.6 0.0 6.4e-09 35.7 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 CCF52824.1 - 1.1e-05 25.7 0.0 3.7e-05 24.0 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 CCF52824.1 - 0.0016 18.6 0.0 0.003 17.7 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 CCF52824.1 - 0.014 15.6 0.0 0.033 14.4 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_C_6 PF17171.4 CCF52824.1 - 0.015 15.0 0.0 0.037 13.8 0.0 1.7 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Ribonuclease_T2 PF00445.18 CCF52825.1 - 3.9e-38 131.5 1.2 5.6e-38 131.0 1.2 1.1 1 0 0 1 1 1 1 Ribonuclease T2 family Sec1 PF00995.23 CCF52826.1 - 1.4e-117 394.3 0.0 1.6e-117 394.1 0.0 1.0 1 0 0 1 1 1 1 Sec1 family DUF1629 PF07791.11 CCF52826.1 - 0.13 12.4 0.0 0.27 11.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1629) tRNA-synt_1e PF01406.19 CCF52827.1 - 2.3e-122 408.1 0.0 3.4e-122 407.5 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.11 CCF52827.1 - 3.3e-09 36.0 0.2 7.7e-05 21.6 0.0 2.2 2 0 0 2 2 2 2 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 CCF52827.1 - 0.00049 18.5 0.6 0.058 11.6 0.0 2.4 3 0 0 3 3 3 2 tRNA synthetases class I (I, L, M and V) DALR_2 PF09190.11 CCF52827.1 - 0.0025 18.2 1.7 0.0039 17.6 0.0 2.2 2 0 0 2 2 2 1 DALR domain tRNA-synt_1c PF00749.21 CCF52827.1 - 0.016 14.1 1.5 0.036 13.0 0.0 2.1 2 0 0 2 2 2 0 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1f PF01921.18 CCF52827.1 - 0.076 11.9 0.0 3.3 6.5 0.0 2.2 2 0 0 2 2 2 0 tRNA synthetases class I (K) HK PF02110.15 CCF52828.1 - 6.1e-63 212.5 1.5 1.5e-60 204.6 1.5 2.2 1 1 0 1 1 1 1 Hydroxyethylthiazole kinase family TMP-TENI PF02581.17 CCF52828.1 - 8.5e-45 152.3 0.0 1.6e-44 151.4 0.0 1.5 1 0 0 1 1 1 1 Thiamine monophosphate synthase Phos_pyr_kin PF08543.12 CCF52828.1 - 0.00014 21.3 0.1 0.00032 20.1 0.1 1.7 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase MFS_1 PF07690.16 CCF52830.1 - 1.9e-46 158.6 42.0 2.9e-46 158.0 42.0 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Pex14_N PF04695.13 CCF52830.1 - 1.6 9.4 4.8 0.2 12.3 0.6 1.7 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF3402 PF11882.8 CCF52831.1 - 4e-121 405.4 0.1 4e-121 405.4 0.1 3.5 2 1 0 3 3 3 1 Domain of unknown function (DUF3402) N1221 PF07923.13 CCF52831.1 - 9e-60 202.3 0.0 1.9e-59 201.3 0.0 1.5 1 0 0 1 1 1 1 N1221-like protein TFIIA PF03153.13 CCF52831.1 - 0.14 12.1 27.8 0.035 14.1 13.9 2.6 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit DUF2722 PF10846.8 CCF52831.1 - 1.3 7.8 23.7 2.4 7.0 2.2 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) NTF2 PF02136.20 CCF52832.1 - 2.8e-35 121.5 0.3 3.1e-35 121.4 0.3 1.0 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain DUF4440 PF14534.6 CCF52832.1 - 0.0085 16.5 0.0 0.0099 16.3 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4440) Imm58 PF15581.6 CCF52832.1 - 0.05 13.7 0.0 0.059 13.5 0.0 1.1 1 0 0 1 1 1 0 Immunity protein 58 SnoaL_4 PF13577.6 CCF52832.1 - 0.052 13.7 0.0 0.055 13.6 0.0 1.1 1 0 0 1 1 1 0 SnoaL-like domain Calreticulin PF00262.18 CCF52833.1 - 1.1e-170 567.4 8.9 1.4e-170 567.1 8.9 1.1 1 0 0 1 1 1 1 Calreticulin family Dynamin_M PF01031.20 CCF52834.1 - 2.8e-103 345.1 0.0 6.9e-102 340.5 0.0 2.3 2 0 0 2 2 2 1 Dynamin central region Dynamin_N PF00350.23 CCF52834.1 - 1.2e-54 184.9 0.0 2.2e-54 184.0 0.0 1.5 1 0 0 1 1 1 1 Dynamin family GED PF02212.18 CCF52834.1 - 3.7e-25 87.9 5.6 3.7e-25 87.9 5.6 2.1 2 0 0 2 2 2 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.23 CCF52834.1 - 0.00049 20.2 0.0 0.0019 18.3 0.0 2.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase Dus PF01207.17 CCF52834.1 - 0.048 12.7 0.0 0.084 11.9 0.0 1.4 1 0 0 1 1 1 0 Dihydrouridine synthase (Dus) SKIP_SNW PF02731.15 CCF52835.1 - 1.3e-67 226.5 1.8 1.3e-67 226.5 1.8 1.8 2 0 0 2 2 2 1 SKIP/SNW domain Cwf_Cwc_15 PF04889.12 CCF52835.1 - 0.0004 20.2 11.1 0.0004 20.2 11.1 1.7 2 0 0 2 2 2 1 Cwf15/Cwc15 cell cycle control protein Bromodomain PF00439.25 CCF52836.1 - 1.2e-51 172.7 0.2 8.3e-19 67.4 0.1 3.6 3 0 0 3 3 3 3 Bromodomain Peptidase_M1 PF01433.20 CCF52836.1 - 2.5e-06 27.2 0.0 4.4e-06 26.4 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M1 domain HEAT_2 PF13646.6 CCF52836.1 - 0.00033 21.0 5.3 0.11 12.9 0.0 4.1 4 0 0 4 4 4 2 HEAT repeats BTB PF00651.31 CCF52838.1 - 7.5e-17 61.6 0.0 2e-08 34.4 0.0 3.3 2 1 1 3 3 3 2 BTB/POZ domain RCC1 PF00415.18 CCF52838.1 - 2e-16 60.3 9.8 0.00065 20.3 0.1 6.2 5 1 0 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 CCF52838.1 - 5.1e-09 35.7 17.3 0.0046 16.7 0.0 6.2 6 0 0 6 6 6 3 Regulator of chromosome condensation (RCC1) repeat Ank_5 PF13857.6 CCF52838.1 - 0.00021 21.5 0.6 0.00062 20.0 0.1 2.0 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 CCF52838.1 - 0.00039 20.9 0.2 0.0011 19.5 0.2 1.9 1 1 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 CCF52838.1 - 0.0012 19.4 0.0 0.0025 18.3 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 CCF52838.1 - 0.0028 18.0 0.3 2.9 8.8 0.0 2.9 2 0 0 2 2 2 2 Ankyrin repeat Ank PF00023.30 CCF52838.1 - 0.021 15.2 0.4 8.1 7.1 0.1 2.9 2 0 0 2 2 2 0 Ankyrin repeat 6PF2K PF01591.18 CCF52839.1 - 1.2e-68 230.7 0.0 2.1e-68 230.0 0.0 1.3 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 CCF52839.1 - 2.2e-33 115.6 0.2 1e-32 113.4 0.0 2.2 3 0 0 3 3 3 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.6 CCF52839.1 - 1.1e-06 28.9 1.1 2.6e-06 27.7 0.0 2.1 2 0 0 2 2 2 1 AAA domain KTI12 PF08433.10 CCF52839.1 - 0.21 11.0 0.0 0.46 9.9 0.0 1.5 1 0 0 1 1 1 0 Chromatin associated protein KTI12 CS PF04969.16 CCF52840.1 - 1.5e-19 70.8 0.8 1.9e-19 70.4 0.2 1.5 2 0 0 2 2 2 1 CS domain Integrase_1 PF12835.7 CCF52840.1 - 0.0083 16.2 0.3 0.014 15.5 0.3 1.4 1 0 0 1 1 1 1 Integrase DUF421 PF04239.12 CCF52840.1 - 0.086 12.6 1.3 0.15 11.9 0.7 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF421) SieB PF14163.6 CCF52840.1 - 0.098 12.1 0.1 0.17 11.4 0.1 1.3 1 0 0 1 1 1 0 Super-infection exclusion protein B MCM_bind PF09739.9 CCF52841.1 - 1.3e-92 311.2 0.0 1.1e-77 261.9 0.0 2.1 2 0 0 2 2 2 2 Mini-chromosome maintenance replisome factor Ala_racemase_N PF01168.20 CCF52841.1 - 9.3e-15 54.9 0.1 3.3e-14 53.1 0.1 1.9 1 1 0 1 1 1 1 Alanine racemase, N-terminal domain Ndr PF03096.14 CCF52841.1 - 0.034 12.9 0.0 0.059 12.1 0.0 1.3 1 0 0 1 1 1 0 Ndr family DUF4743 PF15916.5 CCF52842.1 - 1.8e-11 44.1 0.0 1.1e-08 35.1 0.0 2.5 2 0 0 2 2 2 2 Domain of unknown function (DUF4743) NUDIX PF00293.28 CCF52842.1 - 2.5e-11 43.7 0.0 5.5e-11 42.6 0.0 1.5 1 0 0 1 1 1 1 NUDIX domain HEAT_EZ PF13513.6 CCF52842.1 - 0.059 13.9 3.0 8.9 6.9 0.1 4.2 3 0 0 3 3 3 0 HEAT-like repeat SPG48 PF14764.6 CCF52842.1 - 0.063 13.8 0.0 0.69 10.4 0.0 2.8 2 0 0 2 2 2 0 AP-5 complex subunit, vesicle trafficking Bac_rhodopsin PF01036.18 CCF52843.1 - 9e-46 156.2 12.8 1.2e-45 155.9 12.8 1.1 1 0 0 1 1 1 1 Bacteriorhodopsin-like protein DUF1810 PF08837.11 CCF52843.1 - 0.0028 17.5 0.1 0.23 11.3 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF1810) DUF2754 PF10953.8 CCF52843.1 - 0.37 11.1 7.4 1 9.7 7.4 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2754) Arteri_Gl PF00951.18 CCF52843.1 - 2.6 7.8 6.5 0.39 10.5 2.0 1.8 2 0 0 2 2 2 0 Arterivirus GL envelope glycoprotein RNA_pol_Rpb1_5 PF04998.17 CCF52844.1 - 6.4e-87 291.4 0.0 1.4e-86 290.2 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 CCF52844.1 - 5.1e-62 209.0 0.1 1e-61 208.0 0.1 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.18 CCF52844.1 - 5.6e-37 127.1 0.0 1.1e-36 126.1 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_1 PF04997.12 CCF52844.1 - 7.8e-26 91.1 9.2 1e-22 80.9 0.0 4.7 6 1 0 6 6 6 3 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_4 PF05000.17 CCF52844.1 - 6e-24 84.1 0.0 3.4e-23 81.6 0.0 2.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 TGS PF02824.21 CCF52844.1 - 0.078 13.0 0.8 0.72 10.0 0.0 3.0 3 1 0 3 3 3 0 TGS domain K_oxygenase PF13434.6 CCF52846.1 - 3.6e-08 32.9 0.0 0.003 16.8 0.0 3.5 2 1 0 2 2 2 2 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.14 CCF52846.1 - 3.9e-05 23.0 0.0 3.5 6.8 0.0 3.5 3 0 0 3 3 3 3 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CCF52846.1 - 0.00081 19.4 0.0 0.54 10.2 0.0 4.0 4 0 0 4 4 4 1 FAD-NAD(P)-binding DAO PF01266.24 CCF52846.1 - 0.035 13.7 1.3 3.4 7.2 0.0 2.9 2 1 0 3 3 3 0 FAD dependent oxidoreductase SSF PF00474.17 CCF52847.1 - 2.1e-18 66.4 20.0 2.9e-18 65.9 20.0 1.2 1 0 0 1 1 1 1 Sodium:solute symporter family CoA_binding_3 PF13727.6 CCF52847.1 - 0.12 12.4 2.2 0.52 10.3 2.2 2.1 1 0 0 1 1 1 0 CoA-binding domain HAD_2 PF13419.6 CCF52848.1 - 6.5e-09 36.1 0.0 1.8e-08 34.7 0.0 1.8 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 CCF52848.1 - 2.7e-08 34.4 0.0 3.5e-08 34.0 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 CCF52848.1 - 0.00023 21.2 0.0 0.00055 19.9 0.0 1.6 1 0 0 1 1 1 1 HAD-hyrolase-like zf-C3HC4 PF00097.25 CCF52849.1 - 1.4e-08 34.4 4.3 3.9e-08 33.0 4.4 1.7 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 CCF52849.1 - 1.7e-07 31.0 6.1 8.5e-07 28.7 3.7 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CCF52849.1 - 2e-07 30.9 5.1 2e-07 30.9 5.1 2.2 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_2 PF13639.6 CCF52849.1 - 2.1e-07 31.1 3.6 8.4e-06 26.0 1.9 2.2 2 0 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.6 CCF52849.1 - 2.8e-05 24.0 5.7 5.3e-05 23.1 5.7 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 CCF52849.1 - 0.00017 21.6 4.4 0.00017 21.6 4.4 2.0 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.6 CCF52849.1 - 0.00093 19.0 8.2 0.0054 16.6 8.2 2.0 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) FYVE PF01363.21 CCF52849.1 - 0.049 13.8 0.6 0.097 12.8 0.6 1.5 1 0 0 1 1 1 0 FYVE zinc finger Prok-RING_4 PF14447.6 CCF52849.1 - 0.2 11.6 6.5 0.48 10.3 3.2 2.3 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 zf-Nse PF11789.8 CCF52849.1 - 0.27 11.1 6.0 0.62 9.9 6.0 1.6 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-RING_11 PF17123.5 CCF52849.1 - 0.98 9.2 6.7 0.95 9.3 4.1 2.2 2 0 0 2 2 2 0 RING-like zinc finger zf-rbx1 PF12678.7 CCF52849.1 - 2 8.7 6.1 6.9 7.0 6.1 1.9 1 1 0 1 1 1 0 RING-H2 zinc finger domain Gly_transf_sug PF04488.15 CCF52850.1 - 1.2e-06 29.0 0.0 2.6e-06 28.0 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif Aminotran_5 PF00266.19 CCF52852.1 - 2.9e-30 105.5 0.0 3.9e-30 105.0 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V UPF0180 PF03698.13 CCF52852.1 - 0.18 12.0 0.0 16 5.7 0.0 2.6 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0180) TRAP_alpha PF03896.16 CCF52853.1 - 0.066 12.4 0.0 0.084 12.1 0.0 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Trypan_PARP PF05887.11 CCF52853.1 - 0.072 13.1 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) MitoNEET_N PF10660.9 CCF52853.1 - 0.15 12.1 1.9 0.47 10.5 0.1 2.2 2 0 0 2 2 2 0 Iron-containing outer mitochondrial membrane protein N-terminus NAD_binding_4 PF07993.12 CCF52854.1 - 1.5e-34 119.3 0.0 4.6e-34 117.8 0.0 1.9 3 0 0 3 3 3 1 Male sterility protein AMP-binding PF00501.28 CCF52854.1 - 5.1e-28 97.8 0.0 3.9e-27 94.9 0.0 2.0 2 0 0 2 2 2 1 AMP-binding enzyme PP-binding PF00550.25 CCF52854.1 - 5.5e-05 23.4 0.0 0.00013 22.2 0.0 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site KR PF08659.10 CCF52854.1 - 0.00019 21.4 0.7 0.0039 17.1 1.4 2.7 2 1 0 2 2 2 1 KR domain Epimerase PF01370.21 CCF52854.1 - 0.0018 17.8 0.0 0.0071 15.8 0.0 2.1 1 1 1 2 2 2 1 NAD dependent epimerase/dehydratase family LsmAD PF06741.13 CCF52855.1 - 1.4e-28 99.3 1.0 1.4e-28 99.3 1.0 2.2 2 0 0 2 2 2 1 LsmAD domain SM-ATX PF14438.6 CCF52855.1 - 7.8e-18 64.4 0.0 1.4e-17 63.6 0.0 1.5 1 0 0 1 1 1 1 Ataxin 2 SM domain DUF5581 PF17744.1 CCF52856.1 - 0.026 13.9 0.1 0.037 13.4 0.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5581) EF_assoc_1 PF08355.12 CCF52858.1 - 4.2e-32 109.6 0.2 2.3e-31 107.2 0.1 2.1 2 0 0 2 2 2 1 EF hand associated Ras PF00071.22 CCF52858.1 - 5.9e-30 104.0 0.0 5e-19 68.5 0.0 2.2 2 0 0 2 2 2 2 Ras family EF_assoc_2 PF08356.12 CCF52858.1 - 7e-28 96.5 0.0 9.1e-27 92.9 0.0 2.4 1 1 0 1 1 1 1 EF hand associated Roc PF08477.13 CCF52858.1 - 1.7e-16 60.5 0.0 7.5e-09 35.8 0.0 2.6 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase EF-hand_7 PF13499.6 CCF52858.1 - 1.1e-08 35.3 0.8 0.0026 18.2 0.2 2.6 2 0 0 2 2 2 2 EF-hand domain pair MMR_HSR1 PF01926.23 CCF52858.1 - 1.6e-08 34.6 0.0 5.8e-05 23.1 0.0 2.6 2 1 0 2 2 2 2 50S ribosome-binding GTPase EF-hand_1 PF00036.32 CCF52858.1 - 1.6e-08 33.5 2.8 0.0036 16.7 0.4 2.6 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 CCF52858.1 - 2.3e-08 33.3 2.2 0.0057 16.5 0.2 2.6 2 0 0 2 2 2 2 EF-hand domain Arf PF00025.21 CCF52858.1 - 1.5e-06 27.8 0.0 0.0058 16.1 0.0 3.3 3 0 0 3 3 3 1 ADP-ribosylation factor family SRPRB PF09439.10 CCF52858.1 - 0.00018 21.0 0.0 0.24 10.8 0.0 2.3 2 0 0 2 2 2 2 Signal recognition particle receptor beta subunit EF-hand_5 PF13202.6 CCF52858.1 - 0.00033 20.0 4.9 0.05 13.1 0.5 2.6 2 0 0 2 2 2 2 EF hand AAA_18 PF13238.6 CCF52858.1 - 0.00036 21.1 0.0 0.074 13.6 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 CCF52858.1 - 0.0023 18.2 0.0 1.6 9.0 0.0 2.6 3 0 0 3 3 2 1 AAA domain RsgA_GTPase PF03193.16 CCF52858.1 - 0.0047 16.8 0.3 1.2 9.0 0.0 3.3 3 0 0 3 3 3 1 RsgA GTPase NOG1 PF06858.14 CCF52858.1 - 0.0058 16.4 0.2 0.54 10.1 0.1 2.5 2 0 0 2 2 2 1 Nucleolar GTP-binding protein 1 (NOG1) AAA_33 PF13671.6 CCF52858.1 - 0.0059 16.8 0.0 1.1 9.4 0.0 2.5 2 0 0 2 2 2 1 AAA domain GTP_EFTU PF00009.27 CCF52858.1 - 0.0072 15.9 0.0 1.6 8.2 0.0 3.1 3 0 0 3 3 3 1 Elongation factor Tu GTP binding domain AAA_16 PF13191.6 CCF52858.1 - 0.0099 16.3 0.0 2.5 8.5 0.0 2.5 2 0 0 2 2 2 1 AAA ATPase domain AAA_25 PF13481.6 CCF52858.1 - 0.012 15.2 0.0 0.53 9.8 0.0 2.4 2 0 0 2 2 2 0 AAA domain Viral_helicase1 PF01443.18 CCF52858.1 - 0.02 14.6 0.0 1.3 8.7 0.0 2.3 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase PduV-EutP PF10662.9 CCF52858.1 - 0.025 14.3 0.0 0.46 10.2 0.0 2.5 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation EF-hand_8 PF13833.6 CCF52858.1 - 0.031 14.1 2.1 3.1 7.7 0.2 2.5 2 0 0 2 2 2 0 EF-hand domain pair AAA_24 PF13479.6 CCF52858.1 - 0.031 14.0 0.1 1.3 8.7 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 CCF52858.1 - 0.034 13.9 0.2 5.7 6.8 0.0 2.6 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_28 PF13521.6 CCF52858.1 - 0.035 14.3 0.0 6.8 6.9 0.0 2.5 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 CCF52858.1 - 0.04 13.8 0.1 1.9 8.4 0.0 2.4 2 0 0 2 2 2 0 NACHT domain AAA PF00004.29 CCF52858.1 - 0.041 14.3 0.0 1.1 9.7 0.0 2.3 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) DUF2075 PF09848.9 CCF52858.1 - 0.048 12.9 0.2 0.29 10.3 0.1 1.9 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2075) AAA_19 PF13245.6 CCF52858.1 - 0.05 13.9 0.4 0.45 10.8 0.1 2.2 2 0 0 2 2 2 0 AAA domain SPARC_Ca_bdg PF10591.9 CCF52858.1 - 0.065 13.6 0.6 8.7 6.7 0.0 3.1 3 0 0 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region Dynamin_N PF00350.23 CCF52858.1 - 0.073 13.1 0.4 13 5.8 0.1 2.6 2 1 1 3 3 3 0 Dynamin family ATP_bind_1 PF03029.17 CCF52858.1 - 0.086 12.6 0.4 29 4.3 0.0 3.5 4 0 0 4 4 4 0 Conserved hypothetical ATP binding protein ABC_tran PF00005.27 CCF52858.1 - 0.09 13.3 0.0 19 5.7 0.0 2.4 2 0 0 2 2 2 0 ABC transporter Rnk_N PF14760.6 CCF52858.1 - 0.092 13.2 0.2 0.43 11.1 0.0 2.1 2 0 0 2 2 2 0 Rnk N-terminus FeoB_N PF02421.18 CCF52858.1 - 0.11 12.1 0.2 0.48 9.9 0.0 2.2 3 0 0 3 3 2 0 Ferrous iron transport protein B RNA_helicase PF00910.22 CCF52858.1 - 0.13 12.7 0.0 5.2 7.5 0.0 2.4 2 0 0 2 2 2 0 RNA helicase EF-hand_10 PF14788.6 CCF52858.1 - 0.16 11.8 2.5 0.44 10.5 0.2 2.2 2 0 0 2 2 2 0 EF hand Zeta_toxin PF06414.12 CCF52858.1 - 0.19 11.0 0.1 23 4.2 0.1 2.4 2 0 0 2 2 2 0 Zeta toxin AAA_7 PF12775.7 CCF52858.1 - 0.23 11.0 0.3 5.1 6.6 0.1 2.2 2 0 0 2 2 2 0 P-loop containing dynein motor region FtsK_SpoIIIE PF01580.18 CCF52858.1 - 0.25 10.7 0.3 2.1 7.7 0.2 2.3 2 1 1 3 3 3 0 FtsK/SpoIIIE family MCM PF00493.23 CCF52858.1 - 0.3 10.2 0.3 0.87 8.6 0.1 1.9 2 0 0 2 2 2 0 MCM P-loop domain USP7_ICP0_bdg PF12436.8 CCF52859.1 - 1.5e-86 289.7 2.5 2.4e-86 289.0 1.2 1.9 2 0 0 2 2 2 1 ICP0-binding domain of Ubiquitin-specific protease 7 USP7_C2 PF14533.6 CCF52859.1 - 2.2e-66 223.5 2.9 1.8e-64 217.2 0.7 2.8 3 0 0 3 3 3 2 Ubiquitin-specific protease C-terminal UCH PF00443.29 CCF52859.1 - 1.4e-50 172.2 0.1 2.3e-50 171.5 0.1 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 CCF52859.1 - 1.1e-20 74.5 0.0 2.8e-20 73.2 0.0 1.7 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase MATH PF00917.26 CCF52859.1 - 6.2e-09 36.0 0.0 8.5e-08 32.3 0.0 2.7 2 1 0 2 2 2 1 MATH domain Rad60-SLD PF11976.8 CCF52859.1 - 0.17 11.7 0.8 1.7 8.5 0.0 3.0 3 1 0 3 3 3 0 Ubiquitin-2 like Rad60 SUMO-like SH3_9 PF14604.6 CCF52860.1 - 5.5e-12 45.4 0.1 9.4e-12 44.6 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 CCF52860.1 - 2e-07 30.5 0.0 3.3e-07 29.8 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 CCF52860.1 - 0.00026 20.6 0.0 0.0006 19.4 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain DUF3431 PF11913.8 CCF52860.1 - 0.0024 17.7 0.9 0.0037 17.1 0.9 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3431) Syndecan PF01034.20 CCF52860.1 - 0.097 12.6 0.1 0.19 11.6 0.1 1.4 1 0 0 1 1 1 0 Syndecan domain Pex2_Pex12 PF04757.14 CCF52861.1 - 3.5e-42 144.5 0.9 4.4e-42 144.2 0.9 1.1 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-RING_2 PF13639.6 CCF52861.1 - 5.4e-09 36.3 9.8 8.2e-09 35.7 9.8 1.3 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 CCF52861.1 - 1e-07 32.1 7.6 1.8e-07 31.3 7.6 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_3 PF13920.6 CCF52861.1 - 1.4e-05 24.9 6.5 2e-05 24.3 6.5 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 CCF52861.1 - 2.4e-05 24.1 9.7 3.9e-05 23.4 9.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CCF52861.1 - 0.00077 19.3 8.8 0.0013 18.5 8.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CCF52861.1 - 0.0011 19.0 4.9 0.0012 18.8 2.5 2.2 1 1 1 2 2 2 1 RING-type zinc-finger zf-ANAPC11 PF12861.7 CCF52861.1 - 0.0015 18.6 4.4 0.0025 17.8 4.4 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_11 PF17123.5 CCF52861.1 - 0.0025 17.5 3.0 0.0051 16.5 3.0 1.6 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_5 PF14634.6 CCF52861.1 - 0.005 16.8 8.0 0.0081 16.1 8.0 1.3 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 CCF52861.1 - 0.047 13.6 7.6 0.079 12.8 7.6 1.4 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-Nse PF11789.8 CCF52861.1 - 0.074 12.9 2.9 0.13 12.1 2.9 1.4 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-C3HC4_4 PF15227.6 CCF52861.1 - 2.3 8.5 7.9 0.68 10.1 4.2 1.9 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING Prp18 PF02840.15 CCF52862.1 - 5.5e-62 208.0 0.1 9.7e-62 207.3 0.1 1.4 1 0 0 1 1 1 1 Prp18 domain PRP4 PF08799.11 CCF52862.1 - 3.5e-11 42.5 6.2 9.9e-11 41.0 6.2 1.8 1 0 0 1 1 1 1 pre-mRNA processing factor 4 (PRP4) like TFIIF_alpha PF05793.12 CCF52862.1 - 3.4 6.2 9.9 6.9 5.1 9.9 1.5 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) COX6B PF02297.17 CCF52863.1 - 1.4e-19 70.1 8.8 1.8e-19 69.7 8.8 1.1 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb APOBEC_C PF05240.14 CCF52863.1 - 0.025 14.5 0.4 0.034 14.1 0.4 1.3 1 0 0 1 1 1 0 APOBEC-like C-terminal domain YozE_SAM_like PF06855.12 CCF52863.1 - 0.039 14.1 0.2 0.064 13.4 0.2 1.5 1 0 0 1 1 1 0 YozE SAM-like fold CHCH PF06747.13 CCF52863.1 - 0.065 13.4 0.3 0.065 13.4 0.3 2.0 2 0 0 2 2 2 0 CHCH domain mRNA_stabil PF13929.6 CCF52863.1 - 0.1 11.6 0.2 0.12 11.4 0.2 1.1 1 0 0 1 1 1 0 mRNA stabilisation Nitroreductase PF00881.24 CCF52864.1 - 5.3e-11 42.9 0.0 7e-11 42.5 0.0 1.2 1 0 0 1 1 1 1 Nitroreductase family Roughex PF06020.11 CCF52865.1 - 1.8 7.6 6.8 2.8 7.0 6.8 1.3 1 0 0 1 1 1 0 Drosophila roughex protein DIM1 PF02966.16 CCF52866.1 - 2.2e-66 221.6 0.1 2.5e-66 221.5 0.1 1.0 1 0 0 1 1 1 1 Mitosis protein DIM1 Thioredoxin PF00085.20 CCF52866.1 - 0.0029 17.6 0.0 0.0037 17.2 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin LUC7 PF03194.15 CCF52867.1 - 9.6e-71 238.4 0.2 9.6e-71 238.4 0.2 2.1 2 0 0 2 2 2 1 LUC7 N_terminus DUF3915 PF13054.6 CCF52867.1 - 8 6.5 14.4 0.39 10.7 6.2 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF3915) ChaC PF04752.12 CCF52868.1 - 4.4e-53 180.0 0.0 8.5e-53 179.1 0.0 1.4 1 0 0 1 1 1 1 ChaC-like protein DnaJ PF00226.31 CCF52868.1 - 4.4e-25 87.6 4.2 1.2e-24 86.2 4.2 1.9 1 0 0 1 1 1 1 DnaJ domain zf-C2H2_jaz PF12171.8 CCF52868.1 - 6.9e-11 42.1 3.4 1.4e-08 34.8 0.6 3.1 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 CCF52868.1 - 1.9e-09 37.6 3.4 3e-06 27.4 0.3 3.5 3 0 0 3 3 3 2 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 CCF52868.1 - 6.5e-06 26.4 1.7 0.029 14.7 0.1 2.6 2 0 0 2 2 2 2 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.6 CCF52868.1 - 0.0053 17.5 1.5 0.96 10.5 0.2 2.7 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2H2 PF00096.26 CCF52868.1 - 0.008 16.6 3.2 0.54 10.8 0.3 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type DUF3091 PF11291.8 CCF52868.1 - 0.08 13.1 0.0 0.28 11.4 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3091) DUF2407_C PF13373.6 CCF52871.1 - 1.1e-15 58.0 1.5 4.1e-14 52.9 0.0 3.4 4 0 0 4 4 4 1 DUF2407 C-terminal domain DUF2407 PF10302.9 CCF52871.1 - 2e-07 31.5 2.3 8.7e-05 23.0 0.9 3.2 2 1 0 2 2 2 1 DUF2407 ubiquitin-like domain ubiquitin PF00240.23 CCF52871.1 - 0.00018 21.2 0.1 0.00036 20.2 0.1 1.4 1 0 0 1 1 1 1 Ubiquitin family Raftlin PF15250.6 CCF52871.1 - 0.099 11.4 0.6 8.5 5.0 0.0 2.0 1 1 0 2 2 2 0 Raftlin Zn_clus PF00172.18 CCF52872.1 - 1.3e-05 25.2 10.5 2.4e-05 24.3 10.5 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 CCF52872.1 - 1.8e-05 23.9 0.2 3.6e-05 22.9 0.2 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain WD40 PF00400.32 CCF52873.1 - 2.7e-16 59.6 2.3 9.7e-05 23.1 0.1 6.0 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF52873.1 - 4e-06 27.0 0.0 5.2 7.4 0.0 4.6 3 1 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CCF52873.1 - 0.075 12.0 0.2 1 8.3 0.0 2.6 2 2 0 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein FA_desaturase PF00487.24 CCF52874.1 - 1.6e-26 93.7 15.0 2.4e-26 93.1 15.0 1.2 1 0 0 1 1 1 1 Fatty acid desaturase Lipid_DES PF08557.10 CCF52874.1 - 1.3e-19 69.3 0.9 2.4e-19 68.5 0.9 1.4 1 0 0 1 1 1 1 Sphingolipid Delta4-desaturase (DES) Macoilin PF09726.9 CCF52874.1 - 0.17 10.4 2.1 0.22 10.1 2.1 1.0 1 0 0 1 1 1 0 Macoilin family FAM199X PF15814.5 CCF52874.1 - 4.8 6.2 9.9 6.8 5.6 9.9 1.1 1 0 0 1 1 1 0 Protein family FAM199X Glycos_transf_1 PF00534.20 CCF52876.1 - 2.1e-28 99.0 0.0 2.8e-27 95.4 0.0 2.1 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 CCF52876.1 - 5.7e-13 49.2 0.1 2.3e-12 47.3 0.1 2.0 1 1 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_1_4 PF13692.6 CCF52876.1 - 1.4e-11 45.0 0.3 8.6e-11 42.4 0.3 2.1 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.6 CCF52876.1 - 6e-05 23.4 0.0 0.00038 20.8 0.0 2.3 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 CCF52876.1 - 0.00061 20.3 0.2 0.0041 17.6 0.1 2.4 2 1 0 2 2 2 1 Glycosyl transferase 4-like domain SAM_2 PF07647.17 CCF52877.1 - 0.13 12.4 0.1 0.33 11.1 0.0 1.7 2 0 0 2 2 2 0 SAM domain (Sterile alpha motif) G-patch PF01585.23 CCF52878.1 - 1.5e-14 53.6 1.8 2.9e-14 52.7 1.8 1.5 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 CCF52878.1 - 9.3e-08 32.1 0.2 2.2e-07 30.9 0.2 1.6 1 0 0 1 1 1 1 G-patch domain zf-C2H2_2 PF12756.7 CCF52878.1 - 0.024 15.0 1.1 0.043 14.1 1.1 1.3 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) RED_N PF07808.13 CCF52878.1 - 0.043 13.4 0.3 0.17 11.4 0.0 2.0 2 0 0 2 2 2 0 RED-like protein N-terminal region SOG2 PF10428.9 CCF52879.1 - 9.6e-182 605.7 8.8 9.6e-182 605.7 8.8 3.5 3 1 1 4 4 4 1 RAM signalling pathway protein LRR_8 PF13855.6 CCF52879.1 - 5.3e-17 61.3 9.1 3.2e-09 36.4 1.3 2.7 2 0 0 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 CCF52879.1 - 2.6e-11 43.6 12.3 9.4e-06 25.9 1.1 4.5 2 1 3 5 5 5 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 CCF52879.1 - 0.014 15.9 6.7 23 6.1 0.2 5.5 6 0 0 6 6 6 0 Leucine Rich Repeat LRR_9 PF14580.6 CCF52879.1 - 0.026 14.0 2.4 2.4 7.6 0.6 2.2 1 1 1 2 2 2 0 Leucine-rich repeat RBM1CTR PF08081.11 CCF52879.1 - 0.13 12.3 2.2 0.49 10.5 0.8 2.8 2 0 0 2 2 2 0 RBM1CTR (NUC064) family LRR_6 PF13516.6 CCF52879.1 - 0.98 9.6 3.1 6 7.2 0.0 3.3 4 0 0 4 4 4 0 Leucine Rich repeat NMT PF01233.19 CCF52880.1 - 1.6e-75 252.3 0.0 2.7e-75 251.6 0.0 1.3 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain NMT_C PF02799.15 CCF52880.1 - 4.7e-74 248.4 0.0 5.2e-73 245.0 0.0 2.3 2 1 0 2 2 2 1 Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain Acetyltransf_9 PF13527.7 CCF52880.1 - 0.00015 21.8 0.0 0.00043 20.4 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CCF52880.1 - 0.0057 16.9 0.0 0.018 15.3 0.0 1.8 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family YL1 PF05764.13 CCF52880.1 - 0.16 12.0 8.3 0.33 11.0 8.3 1.5 1 0 0 1 1 1 0 YL1 nuclear protein RAB3GAP2_N PF14655.6 CCF52881.1 - 0.11 11.7 0.0 0.18 11.0 0.0 1.3 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Cwf_Cwc_15 PF04889.12 CCF52881.1 - 0.85 9.3 22.8 0.041 13.6 17.1 1.6 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein RNA_pol_3_Rpc31 PF11705.8 CCF52881.1 - 4.6 7.4 22.2 0.26 11.5 17.0 1.6 2 0 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 Cep57_MT_bd PF06657.13 CCF52882.1 - 9.4e-16 58.0 1.7 9.4e-16 58.0 1.7 3.5 3 0 0 3 3 3 1 Centrosome microtubule-binding domain of Cep57 Na_Ca_ex_C PF16494.5 CCF52882.1 - 0.032 14.7 0.6 0.11 13.0 0.6 1.9 1 0 0 1 1 1 0 C-terminal extension of sodium/calcium exchanger domain RabGAP-TBC PF00566.18 CCF52883.1 - 8.3e-31 107.3 0.8 7.4e-30 104.2 0.2 2.4 2 1 0 2 2 2 1 Rab-GTPase-TBC domain PH_RBD PF12068.8 CCF52883.1 - 1.3e-06 28.0 0.0 7.6e-05 22.3 0.0 2.6 2 0 0 2 2 2 2 Rab-binding domain (RBD) YjeF_N PF03853.15 CCF52884.1 - 1.2e-32 113.2 0.0 1.5e-32 112.8 0.0 1.2 1 0 0 1 1 1 1 YjeF-related protein N-terminus GATA PF00320.27 CCF52886.1 - 1e-13 50.6 3.7 2e-13 49.7 3.7 1.5 1 0 0 1 1 1 1 GATA zinc finger PAS_3 PF08447.12 CCF52886.1 - 4.2e-10 39.8 0.0 9.8e-09 35.4 0.0 2.6 2 0 0 2 2 2 1 PAS fold PAS PF00989.25 CCF52886.1 - 2.8e-08 33.7 0.0 1.5e-07 31.4 0.0 2.1 2 0 0 2 2 2 1 PAS fold PAS_4 PF08448.10 CCF52886.1 - 1.9e-06 28.1 0.0 6.7e-06 26.3 0.0 1.9 1 0 0 1 1 1 1 PAS fold PAS_9 PF13426.7 CCF52886.1 - 5.2e-06 26.6 0.0 1.2e-05 25.5 0.0 1.6 1 0 0 1 1 1 1 PAS domain PAS_11 PF14598.6 CCF52886.1 - 0.00014 21.9 0.0 0.0003 20.9 0.0 1.5 1 0 0 1 1 1 1 PAS domain TF_Zn_Ribbon PF08271.12 CCF52886.1 - 0.068 12.7 0.4 0.34 10.4 0.0 2.2 2 0 0 2 2 2 0 TFIIB zinc-binding Luteo_Vpg PF01659.16 CCF52886.1 - 0.21 11.9 2.0 0.6 10.5 0.3 2.4 2 0 0 2 2 2 0 Luteovirus putative VPg genome linked protein UBX PF00789.20 CCF52887.1 - 4.6e-13 49.2 0.0 9.3e-13 48.2 0.0 1.5 1 0 0 1 1 1 1 UBX domain ARGLU PF15346.6 CCF52887.1 - 0.69 9.8 24.4 1.3 8.9 24.4 1.4 1 0 0 1 1 1 0 Arginine and glutamate-rich 1 DUF874 PF05917.11 CCF52887.1 - 0.94 8.4 6.2 1.5 7.8 6.2 1.2 1 0 0 1 1 1 0 Helicobacter pylori protein of unknown function (DUF874) WD40 PF00400.32 CCF52889.1 - 5e-33 112.6 13.6 4.2e-06 27.4 0.2 11.3 11 0 0 11 11 11 5 WD domain, G-beta repeat Utp12 PF04003.12 CCF52889.1 - 9.1e-20 71.0 0.0 1.4e-19 70.3 0.0 1.3 1 0 0 1 1 1 1 Dip2/Utp12 Family ANAPC4_WD40 PF12894.7 CCF52889.1 - 6.4e-18 64.9 0.0 0.0079 16.5 0.0 8.6 3 2 6 9 9 9 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CCF52889.1 - 3.1e-06 26.4 4.5 3.5 6.5 0.1 5.8 3 3 2 5 5 5 4 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 CCF52889.1 - 0.0026 16.5 0.0 4.4 5.8 0.0 3.8 4 1 1 5 5 5 1 Nucleoporin Nup120/160 WD40_like PF17005.5 CCF52889.1 - 0.015 14.6 0.0 0.49 9.7 0.0 3.1 4 0 0 4 4 4 0 WD40-like domain PALB2_WD40 PF16756.5 CCF52889.1 - 0.024 13.6 0.0 3.2 6.6 0.1 2.8 3 0 0 3 3 3 0 Partner and localizer of BRCA2 WD40 domain DUF1513 PF07433.11 CCF52889.1 - 0.066 12.3 0.3 1.2 8.2 0.1 2.9 3 1 1 4 4 4 0 Protein of unknown function (DUF1513) Cytochrom_D1 PF02239.16 CCF52889.1 - 0.084 11.4 0.0 5.9 5.3 0.0 3.3 4 1 0 4 4 4 0 Cytochrome D1 heme domain SUI1 PF01253.22 CCF52891.1 - 8.5e-28 96.7 2.0 1.2e-27 96.3 2.0 1.2 1 0 0 1 1 1 1 Translation initiation factor SUI1 CoA_trans PF01144.23 CCF52893.1 - 5.5e-104 346.3 0.8 7.4e-63 211.8 0.0 2.0 2 0 0 2 2 2 2 Coenzyme A transferase AcetylCoA_hyd_C PF13336.6 CCF52893.1 - 0.0024 17.8 0.1 0.0053 16.7 0.1 1.5 1 0 0 1 1 1 1 Acetyl-CoA hydrolase/transferase C-terminal domain DeoRC PF00455.22 CCF52893.1 - 0.0049 16.8 0.0 1.2 9.1 0.0 2.8 3 0 0 3 3 3 2 DeoR C terminal sensor domain Sprouty PF05210.13 CCF52894.1 - 3 8.3 4.5 13 6.3 0.0 3.2 3 0 0 3 3 3 0 Sprouty protein (Spry) DcpS_C PF11969.8 CCF52895.1 - 8.8e-12 45.5 7.7 5.9e-06 26.7 4.2 2.7 3 0 0 3 3 3 2 Scavenger mRNA decapping enzyme C-term binding zf-C2HE PF16278.5 CCF52895.1 - 4.2e-11 43.1 0.0 9.8e-11 42.0 0.0 1.7 1 0 0 1 1 1 1 C2HE / C2H2 / C2HC zinc-binding finger HIT PF01230.23 CCF52895.1 - 9.9e-11 42.2 6.9 0.00049 20.8 5.0 3.1 1 1 2 3 3 3 2 HIT domain Thioredoxin_8 PF13905.6 CCF52896.1 - 3.2e-09 37.0 0.0 7.5e-08 32.6 0.0 2.2 2 0 0 2 2 2 1 Thioredoxin-like ArgJ PF01960.18 CCF52897.1 - 2.2e-133 444.6 0.0 2.6e-133 444.4 0.0 1.0 1 0 0 1 1 1 1 ArgJ family AroM PF07302.11 CCF52897.1 - 0.12 11.7 0.1 0.38 10.1 0.0 1.7 2 0 0 2 2 2 0 AroM protein ATP-grasp PF02222.22 CCF52897.1 - 0.16 11.5 0.0 0.29 10.7 0.0 1.3 1 0 0 1 1 1 0 ATP-grasp domain CENP-N PF05238.13 CCF52898.1 - 1.9e-72 244.9 0.0 2.4e-72 244.5 0.0 1.0 1 0 0 1 1 1 1 Kinetochore protein CHL4 like DUF1690 PF07956.11 CCF52899.1 - 2.1e-30 106.0 11.6 2.6e-30 105.7 11.6 1.1 1 0 0 1 1 1 1 Protein of Unknown function (DUF1690) STAT_int PF02865.17 CCF52899.1 - 0.00061 20.2 1.8 0.0013 19.2 1.2 1.7 1 1 1 2 2 2 1 STAT protein, protein interaction domain Rootletin PF15035.6 CCF52899.1 - 0.029 14.4 8.4 0.21 11.6 7.9 1.9 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion Piwi PF02171.17 CCF52899.1 - 0.043 13.0 0.1 0.075 12.3 0.1 1.4 1 0 0 1 1 1 0 Piwi domain Fzo_mitofusin PF04799.13 CCF52899.1 - 0.076 12.6 2.3 0.12 11.9 2.3 1.3 1 0 0 1 1 1 0 fzo-like conserved region FliT PF05400.13 CCF52899.1 - 0.11 13.3 4.3 7.6 7.4 1.7 2.4 2 0 0 2 2 2 0 Flagellar protein FliT SNAPc19 PF15497.6 CCF52899.1 - 0.13 12.8 4.7 0.27 11.7 4.7 1.6 1 0 0 1 1 1 0 snRNA-activating protein complex subunit 19, SNAPc subunit 19 DUF4407 PF14362.6 CCF52899.1 - 0.29 10.4 9.7 0.34 10.2 9.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) AAA_11 PF13086.6 CCF52899.1 - 0.36 10.6 6.3 0.41 10.4 6.3 1.3 1 0 0 1 1 1 0 AAA domain DUF4140 PF13600.6 CCF52899.1 - 0.42 11.1 9.3 55 4.3 9.2 2.4 1 1 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) LMBR1 PF04791.16 CCF52899.1 - 4.7 6.0 5.0 5.3 5.8 5.0 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein Seryl_tRNA_N PF02403.22 CCF52899.1 - 8.7 6.6 14.2 3.8 7.8 9.3 2.2 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Phos_pyr_kin PF08543.12 CCF52900.1 - 7.4e-10 38.6 0.0 1.1e-09 38.0 0.0 1.2 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase PfkB PF00294.24 CCF52900.1 - 7.4e-07 28.8 0.0 1.3e-06 27.9 0.0 1.4 1 0 0 1 1 1 1 pfkB family carbohydrate kinase RED_N PF07808.13 CCF52901.1 - 8.2e-09 35.4 6.9 8.2e-09 35.4 6.9 2.4 2 0 0 2 2 2 1 RED-like protein N-terminal region Copper-fist PF00649.18 CCF52902.1 - 7.7e-15 54.1 2.3 7.7e-15 54.1 2.3 2.5 2 0 0 2 2 2 1 Copper fist DNA binding domain HAT PF02184.16 CCF52903.1 - 2.1e-23 81.9 51.7 1e-08 35.0 0.0 13.4 14 1 0 14 14 14 5 HAT (Half-A-TPR) repeat TPR_14 PF13428.6 CCF52903.1 - 4.4e-17 61.3 33.7 0.0099 16.6 0.1 11.8 7 4 5 12 12 12 7 Tetratricopeptide repeat TPR_2 PF07719.17 CCF52903.1 - 8.5e-14 50.5 6.9 0.011 15.8 0.1 8.5 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_19 PF14559.6 CCF52903.1 - 1.8e-13 50.8 5.4 0.0012 19.3 0.0 6.8 5 3 2 7 7 7 3 Tetratricopeptide repeat Suf PF05843.14 CCF52903.1 - 1.2e-08 35.3 25.9 0.0047 17.0 0.1 6.6 2 2 3 5 5 5 3 Suppressor of forked protein (Suf) TPR_1 PF00515.28 CCF52903.1 - 1.6e-08 34.0 0.1 0.5 10.3 0.0 6.1 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_8 PF13181.6 CCF52903.1 - 7.2e-08 32.0 3.3 0.0063 16.6 0.1 6.3 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_17 PF13431.6 CCF52903.1 - 3.3e-07 30.2 1.7 5.3e-05 23.3 0.0 5.0 6 0 0 6 6 4 1 Tetratricopeptide repeat Mad3_BUB1_I PF08311.12 CCF52903.1 - 0.00028 20.8 24.0 0.019 15.0 2.6 7.0 6 2 1 7 7 7 2 Mad3/BUB1 homology region 1 TPR_11 PF13414.6 CCF52903.1 - 0.00031 20.4 3.1 3.3 7.5 0.0 5.9 8 0 0 8 8 8 1 TPR repeat Fis1_TPR_C PF14853.6 CCF52903.1 - 0.0019 18.2 3.7 0.29 11.2 0.0 4.2 5 0 0 5 5 5 1 Fis1 C-terminal tetratricopeptide repeat TPR_12 PF13424.6 CCF52903.1 - 0.0047 17.2 14.0 1.3 9.3 0.3 6.1 5 2 0 5 5 5 2 Tetratricopeptide repeat TPR_6 PF13174.6 CCF52903.1 - 0.0086 16.7 16.0 24 5.8 0.4 8.7 8 1 1 9 9 9 0 Tetratricopeptide repeat TPR_7 PF13176.6 CCF52903.1 - 0.038 14.0 19.6 3.5 7.9 0.0 8.2 10 0 0 10 10 9 0 Tetratricopeptide repeat U3_assoc_6 PF08640.11 CCF52903.1 - 0.09 12.9 0.1 0.09 12.9 0.1 5.6 5 3 3 8 8 8 0 U3 small nucleolar RNA-associated protein 6 SET PF00856.28 CCF52904.1 - 1.3e-20 74.4 0.1 1.3e-20 74.4 0.1 4.2 4 1 0 4 4 4 1 SET domain N-SET PF11764.8 CCF52904.1 - 2.6e-13 50.5 1.9 2.6e-13 50.5 1.9 7.0 6 2 1 7 7 7 1 COMPASS (Complex proteins associated with Set1p) component N SET_assoc PF11767.8 CCF52904.1 - 9.7e-06 25.1 0.0 1.8e-05 24.2 0.0 1.5 1 0 0 1 1 1 1 Histone lysine methyltransferase SET associated Metallophos_2 PF12850.7 CCF52905.1 - 3.2e-20 73.0 0.1 5.7e-20 72.2 0.1 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.28 CCF52905.1 - 0.0006 20.4 1.9 0.23 11.9 0.3 2.4 1 1 1 2 2 2 2 Calcineurin-like phosphoesterase Borrelia_P83 PF05262.11 CCF52905.1 - 0.015 13.9 12.7 0.023 13.2 12.7 1.2 1 0 0 1 1 1 0 Borrelia P83/100 protein FAM60A PF15396.6 CCF52905.1 - 0.076 13.0 2.7 0.11 12.5 2.7 1.2 1 0 0 1 1 1 0 Protein Family FAM60A SAPS PF04499.15 CCF52905.1 - 0.11 11.3 3.0 0.13 11.0 3.0 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein NPR3 PF03666.13 CCF52905.1 - 0.15 10.8 5.4 0.18 10.5 5.4 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 RPOL_N PF14700.6 CCF52905.1 - 0.16 11.3 5.3 0.21 10.9 5.3 1.1 1 0 0 1 1 1 0 DNA-directed RNA polymerase N-terminal Connexin PF00029.19 CCF52905.1 - 0.21 11.3 2.1 0.39 10.4 2.1 1.4 1 0 0 1 1 1 0 Connexin RR_TM4-6 PF06459.12 CCF52905.1 - 0.33 10.7 9.2 0.45 10.3 9.2 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Zip PF02535.22 CCF52905.1 - 0.35 10.1 2.2 0.41 9.8 2.2 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Tim54 PF11711.8 CCF52905.1 - 0.51 9.1 6.0 0.79 8.4 6.0 1.3 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 MCM_bind PF09739.9 CCF52905.1 - 0.74 8.2 5.7 0.97 7.8 5.7 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor CDC45 PF02724.14 CCF52905.1 - 1 7.6 7.1 1.2 7.3 7.1 1.1 1 0 0 1 1 1 0 CDC45-like protein Vfa1 PF08432.10 CCF52905.1 - 1 9.6 14.7 1.7 9.0 14.7 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Hid1 PF12722.7 CCF52905.1 - 1.2 7.1 2.2 1.5 6.9 2.2 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF913 PF06025.12 CCF52905.1 - 1.6 7.7 4.5 2.2 7.2 4.5 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Pannexin_like PF12534.8 CCF52905.1 - 2.1 7.4 5.3 2.8 6.9 5.3 1.1 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 Sec62 PF03839.16 CCF52905.1 - 2.7 7.4 8.0 3.8 6.9 8.0 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 SLC12 PF03522.15 CCF52905.1 - 2.9 6.8 6.2 3.8 6.4 6.2 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Presenilin PF01080.17 CCF52905.1 - 3.8 6.2 10.4 5.2 5.7 10.4 1.1 1 0 0 1 1 1 0 Presenilin Pentapeptide_2 PF01469.18 CCF52908.1 - 2e-08 34.0 9.7 1.7e-05 24.6 2.0 2.7 1 1 1 2 2 2 2 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.6 CCF52908.1 - 0.003 17.7 9.4 0.0057 16.8 9.4 1.4 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) LSM PF01423.22 CCF52909.1 - 2.4e-15 56.0 0.1 3e-15 55.7 0.1 1.1 1 0 0 1 1 1 1 LSM domain Hfq PF17209.3 CCF52909.1 - 0.049 13.3 0.0 0.078 12.6 0.0 1.5 1 0 0 1 1 1 0 Hfq protein Arf PF00025.21 CCF52910.1 - 6.6e-75 250.4 0.1 7.4e-75 250.2 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 CCF52910.1 - 3.6e-15 56.2 0.0 4.8e-15 55.8 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 CCF52910.1 - 2.4e-13 50.0 0.0 2.8e-13 49.8 0.0 1.0 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 CCF52910.1 - 4.4e-12 45.8 0.3 5.2e-07 29.2 0.1 2.4 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.10 CCF52910.1 - 6.4e-11 42.0 0.0 7.9e-11 41.7 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 CCF52910.1 - 6.2e-10 38.8 0.0 7.8e-10 38.5 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 CCF52910.1 - 2.6e-05 24.3 0.0 5.3e-05 23.3 0.0 1.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 CCF52910.1 - 0.076 12.5 0.2 0.3 10.6 0.2 2.0 1 1 0 1 1 1 0 Ferrous iron transport protein B NOG1 PF06858.14 CCF52910.1 - 0.15 11.9 0.0 0.26 11.1 0.0 1.4 1 0 0 1 1 1 0 Nucleolar GTP-binding protein 1 (NOG1) DUF21 PF01595.20 CCF52912.1 - 3e-36 124.8 0.2 5.2e-36 124.0 0.2 1.4 1 0 0 1 1 1 1 Cyclin M transmembrane N-terminal domain CBS PF00571.28 CCF52912.1 - 0.018 15.5 0.3 9.4 6.8 0.0 3.5 3 0 0 3 3 3 0 CBS domain Aldo_ket_red PF00248.21 CCF52913.1 - 4e-29 101.7 0.0 1.1e-28 100.3 0.0 1.7 1 1 0 1 1 1 1 Aldo/keto reductase family RPN6_N PF18055.1 CCF52914.1 - 1.3e-43 148.1 5.9 4.6e-43 146.3 3.1 2.6 2 0 0 2 2 2 1 26S proteasome regulatory subunit RPN6 N-terminal domain PCI PF01399.27 CCF52914.1 - 6.8e-19 68.3 1.3 1.1e-18 67.7 0.2 2.0 2 0 0 2 2 2 1 PCI domain RPN6_C_helix PF18503.1 CCF52914.1 - 9.7e-12 44.4 1.1 1.9e-11 43.5 1.1 1.5 1 0 0 1 1 1 1 26S proteasome subunit RPN6 C-terminal helix domain TPR_16 PF13432.6 CCF52914.1 - 0.006 17.2 6.9 0.23 12.1 0.0 4.0 4 1 0 4 4 4 1 Tetratricopeptide repeat Vps39_1 PF10366.9 CCF52914.1 - 0.021 15.1 2.0 0.093 13.0 0.7 2.3 1 1 1 2 2 2 0 Vacuolar sorting protein 39 domain 1 ANAPC3 PF12895.7 CCF52914.1 - 0.14 12.4 2.5 0.4 10.9 0.1 2.9 3 1 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 Aminotran_1_2 PF00155.21 CCF52915.1 - 3.9e-31 108.5 0.0 4.9e-31 108.2 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II ABC_membrane PF00664.23 CCF52916.1 - 6.6e-36 124.4 14.0 1e-35 123.7 14.0 1.3 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 CCF52916.1 - 2.7e-34 118.6 0.0 6.9e-34 117.3 0.0 1.8 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 CCF52916.1 - 6.8e-06 25.7 0.2 0.00026 20.5 0.2 2.2 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 CCF52916.1 - 1.1e-05 25.9 0.2 3.6e-05 24.2 0.2 1.8 1 0 0 1 1 1 1 AAA ATPase domain MTABC_N PF16185.5 CCF52916.1 - 0.0019 17.7 1.5 0.0076 15.8 0.0 2.7 2 1 0 2 2 2 1 Mitochondrial ABC-transporter N-terminal five TM region AAA_22 PF13401.6 CCF52916.1 - 0.0022 18.3 0.1 0.014 15.7 0.1 2.2 1 1 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 CCF52916.1 - 0.0091 15.9 0.0 0.021 14.7 0.0 1.6 1 0 0 1 1 1 1 RsgA GTPase AAA_15 PF13175.6 CCF52916.1 - 0.019 14.7 0.0 0.019 14.7 0.0 1.7 3 0 0 3 3 2 0 AAA ATPase domain AAA PF00004.29 CCF52916.1 - 0.02 15.3 0.0 0.14 12.6 0.0 2.2 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.6 CCF52916.1 - 0.022 14.5 0.1 0.087 12.6 0.1 2.0 1 0 0 1 1 1 0 P-loop containing region of AAA domain IstB_IS21 PF01695.17 CCF52916.1 - 0.024 14.4 0.1 0.16 11.7 0.0 2.3 3 0 0 3 3 2 0 IstB-like ATP binding protein AAA_21 PF13304.6 CCF52916.1 - 0.026 14.4 0.0 0.06 13.2 0.0 1.6 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system Zeta_toxin PF06414.12 CCF52916.1 - 0.035 13.4 0.0 0.075 12.3 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin AAA_5 PF07728.14 CCF52916.1 - 0.099 12.6 0.0 6.9 6.7 0.0 3.1 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) Methyltransf_23 PF13489.6 CCF52916.1 - 0.15 11.8 0.0 0.38 10.6 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain DUF2721 PF11026.8 CCF52916.1 - 7.1 6.5 9.9 2.2 8.2 0.0 3.2 3 0 0 3 3 2 0 Protein of unknown function (DUF2721) DUF2408 PF10303.9 CCF52917.1 - 1.1e-52 178.2 5.8 1.6e-38 132.3 0.0 4.5 3 2 1 4 4 4 4 Protein of unknown function (DUF2408) DUF2514 PF10721.9 CCF52917.1 - 0.058 13.4 1.8 0.37 10.8 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2514) YabA PF06156.13 CCF52917.1 - 0.097 13.3 0.1 3 8.6 0.0 3.0 2 1 0 2 2 2 0 Initiation control protein YabA DUF1043 PF06295.12 CCF52917.1 - 0.1 12.6 0.6 0.35 10.9 0.6 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1043) STN1_2 PF09170.10 CCF52917.1 - 0.11 12.7 0.7 0.37 11.0 0.7 1.9 1 0 0 1 1 1 0 CST, Suppressor of cdc thirteen homolog, complex subunit STN1 Macoilin PF09726.9 CCF52917.1 - 0.15 10.6 1.2 0.3 9.6 1.2 1.4 1 0 0 1 1 1 0 Macoilin family DUF724 PF05266.14 CCF52917.1 - 0.19 11.5 2.1 0.27 11.0 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF724) Imm5 PF14423.6 CCF52917.1 - 0.43 10.8 3.0 0.19 12.0 0.4 1.7 2 0 0 2 2 2 0 Immunity protein Imm5 BUD22 PF09073.10 CCF52917.1 - 0.79 9.0 8.3 1.9 7.7 3.4 2.2 2 0 0 2 2 2 0 BUD22 DUF465 PF04325.13 CCF52917.1 - 1.3 9.2 5.4 4 7.5 5.4 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF465) FlgN PF05130.12 CCF52917.1 - 8.4 6.9 7.3 23 5.5 0.0 3.4 3 0 0 3 3 3 0 FlgN protein Ran_BP1 PF00638.18 CCF52918.1 - 4.2e-14 52.9 0.4 7.8e-14 52.0 0.4 1.4 1 0 0 1 1 1 1 RanBP1 domain DUF948 PF06103.11 CCF52918.1 - 0.064 13.5 0.1 7.9 6.8 0.0 2.6 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Gti1_Pac2 PF09729.9 CCF52919.1 - 2.9e-34 118.7 4.5 5.4e-30 104.8 0.0 3.1 2 1 1 3 3 3 2 Gti1/Pac2 family Laps PF10169.9 CCF52921.1 - 0.063 13.9 0.6 0.16 12.5 0.6 1.6 1 0 0 1 1 1 0 Learning-associated protein DUF4934 PF16288.5 CCF52922.1 - 0.014 15.3 0.0 0.024 14.5 0.0 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4934) IPPT PF01715.17 CCF52922.1 - 0.014 15.2 0.0 0.016 15.0 0.0 1.1 1 0 0 1 1 1 0 IPP transferase Pox_G9-A16 PF03003.16 CCF52922.1 - 0.083 12.6 1.1 0.1 12.3 1.1 1.2 1 0 0 1 1 1 0 Pox virus entry-fusion-complex G9/A16 UBA2_C PF16195.5 CCF52922.1 - 0.12 13.0 1.2 0.19 12.5 0.4 1.7 2 0 0 2 2 2 0 SUMO-activating enzyme subunit 2 C-terminus RVT_2 PF07727.14 CCF52923.1 - 4.2e-27 95.3 0.1 4.7e-27 95.2 0.1 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Zds_C PF08632.10 CCF52924.1 - 5.4e-28 96.5 1.6 1.2e-27 95.4 1.6 1.6 1 0 0 1 1 1 1 Activator of mitotic machinery Cdc14 phosphatase activation C-term Connexin PF00029.19 CCF52924.1 - 5.7 6.6 5.1 14 5.3 5.1 1.6 1 0 0 1 1 1 0 Connexin Polysacc_deac_1 PF01522.21 CCF52926.1 - 1.4e-27 96.0 0.0 2.4e-27 95.3 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide deacetylase SAP PF02037.27 CCF52927.1 - 0.069 12.9 0.1 0.19 11.5 0.1 1.7 1 0 0 1 1 1 0 SAP domain RdRP PF05183.12 CCF52928.1 - 1.6e-114 383.7 0.0 2.5e-114 383.1 0.0 1.2 1 0 0 1 1 1 1 RNA dependent RNA polymerase Aconitase PF00330.20 CCF52929.1 - 1.6e-148 495.6 0.0 2.1e-148 495.2 0.0 1.2 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 CCF52929.1 - 1.9e-32 112.3 0.0 3.6e-32 111.5 0.0 1.5 1 0 0 1 1 1 1 Aconitase C-terminal domain MRP-L28 PF09812.9 CCF52929.1 - 8.7e-06 26.0 3.0 2e-05 24.8 1.3 2.1 2 0 0 2 2 2 1 Mitochondrial ribosomal protein L28 DUF2963 PF11178.8 CCF52929.1 - 0.2 11.4 0.2 0.55 10.0 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2963) CwfJ_C_2 PF04676.14 CCF52930.1 - 3.1e-32 111.4 1.7 3.4e-32 111.2 0.0 2.0 2 0 0 2 2 2 1 Protein similar to CwfJ C-terminus 2 CwfJ_C_1 PF04677.15 CCF52930.1 - 1.5e-20 73.2 0.0 2.3e-20 72.7 0.0 1.3 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 Peptidase_M13_N PF05649.13 CCF52931.1 - 1.9e-96 324.0 0.0 2.8e-96 323.5 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M13 Peptidase_M13 PF01431.21 CCF52931.1 - 2.5e-58 197.1 0.0 3.8e-58 196.5 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M13 IMD PF08397.11 CCF52931.1 - 0.22 10.9 5.7 0.38 10.1 5.7 1.3 1 0 0 1 1 1 0 IRSp53/MIM homology domain DUF2040 PF09745.9 CCF52932.1 - 3.8e-36 123.8 25.6 3.8e-36 123.8 25.6 2.9 2 1 0 2 2 2 1 Coiled-coil domain-containing protein 55 (DUF2040) Vps55 PF04133.14 CCF52933.1 - 4.8e-43 145.8 6.7 5.4e-43 145.7 6.7 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting 55 zf-RING_4 PF14570.6 CCF52934.1 - 1.1e-21 76.4 11.6 1.7e-21 75.7 11.6 1.4 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-C3HC4_3 PF13920.6 CCF52934.1 - 9.8e-07 28.5 8.9 1.6e-06 27.8 8.9 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 CCF52934.1 - 4.2e-05 23.3 8.9 0.00059 19.6 5.3 2.3 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 RRM_1 PF00076.22 CCF52934.1 - 0.0031 17.3 0.1 0.013 15.3 0.1 2.1 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-RING_2 PF13639.6 CCF52934.1 - 0.0042 17.4 11.8 0.0069 16.7 11.8 1.4 1 0 0 1 1 1 1 Ring finger domain zf-UDP PF14569.6 CCF52934.1 - 0.031 14.4 4.2 0.062 13.4 4.2 1.4 1 0 0 1 1 1 0 Zinc-binding RING-finger zf-C3HC4_2 PF13923.6 CCF52934.1 - 0.31 10.9 11.5 0.55 10.1 11.5 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CCF52934.1 - 0.78 9.7 11.5 1.4 8.9 11.5 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CCF52934.1 - 1.5 8.9 7.9 7.8 6.6 8.5 2.0 1 1 1 2 2 2 0 RING-type zinc-finger Baculo_IE-1 PF05290.11 CCF52934.1 - 1.6 8.7 9.6 0.5 10.3 6.2 1.8 1 1 1 2 2 2 0 Baculovirus immediate-early protein (IE-0) SRP54 PF00448.22 CCF52935.1 - 3.7e-75 251.9 1.4 3.8e-75 251.8 0.1 1.7 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain SRP_SPB PF02978.19 CCF52935.1 - 1.5e-30 105.8 0.3 1.5e-30 105.8 0.3 4.2 3 1 0 3 3 3 1 Signal peptide binding domain SRP54_N PF02881.19 CCF52935.1 - 3.7e-17 62.3 0.5 9.7e-17 61.0 0.5 1.8 1 0 0 1 1 1 1 SRP54-type protein, helical bundle domain AAA_33 PF13671.6 CCF52935.1 - 3.5e-05 24.0 0.4 9.5e-05 22.6 0.0 1.9 2 0 0 2 2 2 1 AAA domain cobW PF02492.19 CCF52935.1 - 4.7e-05 23.0 1.4 0.00016 21.3 0.4 2.3 2 1 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_17 PF13207.6 CCF52935.1 - 0.0076 16.7 0.6 0.024 15.0 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 CCF52935.1 - 0.0078 16.6 0.1 0.029 14.8 0.0 2.0 2 0 0 2 2 2 1 AAA ATPase domain MeaB PF03308.16 CCF52935.1 - 0.011 14.8 0.9 0.094 11.7 0.0 2.5 2 1 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_22 PF13401.6 CCF52935.1 - 0.02 15.2 0.0 0.063 13.6 0.0 1.9 1 0 0 1 1 1 0 AAA domain APS_kinase PF01583.20 CCF52935.1 - 0.031 14.2 0.0 0.058 13.3 0.0 1.4 1 0 0 1 1 1 0 Adenylylsulphate kinase MobB PF03205.14 CCF52935.1 - 0.033 14.1 0.0 0.069 13.0 0.0 1.5 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B CbiA PF01656.23 CCF52935.1 - 0.037 14.1 0.0 0.084 12.9 0.0 1.7 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain Zeta_toxin PF06414.12 CCF52935.1 - 0.046 13.0 0.0 0.088 12.1 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin ATP_bind_1 PF03029.17 CCF52935.1 - 0.081 12.7 0.1 0.19 11.5 0.1 1.6 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein 6PF2K PF01591.18 CCF52935.1 - 0.12 11.7 0.0 0.21 10.9 0.0 1.3 1 0 0 1 1 1 0 6-phosphofructo-2-kinase AAA_28 PF13521.6 CCF52935.1 - 0.13 12.5 0.2 0.35 11.1 0.0 1.8 2 1 0 2 2 1 0 AAA domain AAA_18 PF13238.6 CCF52935.1 - 0.14 12.7 0.0 0.31 11.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 CCF52935.1 - 0.17 11.9 1.0 0.81 9.8 0.2 2.5 2 1 0 2 2 2 0 50S ribosome-binding GTPase Arm PF00514.23 CCF52936.1 - 0.041 13.9 2.0 2 8.6 0.0 4.1 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat KAP PF05804.12 CCF52936.1 - 0.24 9.5 0.1 0.67 8.0 0.0 1.7 2 0 0 2 2 2 0 Kinesin-associated protein (KAP) Rot1 PF10681.9 CCF52937.1 - 2.4e-52 177.5 2.2 2.9e-52 177.2 2.2 1.1 1 0 0 1 1 1 1 Chaperone for protein-folding within the ER, fungal VanZ PF04892.12 CCF52938.1 - 0.0004 21.0 2.3 0.00089 19.9 2.4 1.4 1 1 0 1 1 1 1 VanZ like family DUF3796 PF12676.7 CCF52938.1 - 0.16 12.4 1.4 0.25 11.8 1.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3796) Cytochrom_B_C PF00032.17 CCF52938.1 - 0.33 11.3 1.8 0.43 10.9 0.2 1.8 1 1 1 2 2 2 0 Cytochrome b(C-terminal)/b6/petD Pinin_SDK_N PF04697.13 CCF52938.1 - 0.71 10.5 3.3 0.75 10.4 2.4 1.4 1 1 0 1 1 1 0 pinin/SDK conserved region TctB PF07331.11 CCF52938.1 - 1.8 8.8 10.7 9.1 6.6 9.6 2.2 1 1 0 1 1 1 0 Tripartite tricarboxylate transporter TctB family LapA_dom PF06305.11 CCF52938.1 - 9 6.2 7.2 18 5.2 0.0 2.8 3 0 0 3 3 3 0 Lipopolysaccharide assembly protein A domain CAP59_mtransfer PF11735.8 CCF52939.1 - 0.046 13.4 0.0 0.054 13.2 0.0 1.0 1 0 0 1 1 1 0 Cryptococcal mannosyltransferase 1 FBPase PF00316.20 CCF52940.1 - 1.5e-72 243.0 0.7 2.2e-72 242.5 0.7 1.2 1 0 0 1 1 1 1 Fructose-1-6-bisphosphatase, N-terminal domain Inositol_P PF00459.25 CCF52940.1 - 0.0067 16.0 0.0 0.011 15.3 0.0 1.2 1 0 0 1 1 1 1 Inositol monophosphatase family Cyclin_N PF00134.23 CCF52942.1 - 1.7e-13 50.5 0.8 3.2e-13 49.5 0.1 1.8 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin PF08613.11 CCF52942.1 - 3.5e-08 34.0 0.0 3.5e-08 34.0 0.0 2.4 3 0 0 3 3 3 1 Cyclin MFS_1 PF07690.16 CCF52943.1 - 6.2e-08 31.9 39.8 4.8e-07 29.0 28.4 4.2 3 1 1 4 4 4 3 Major Facilitator Superfamily Sin3a_C PF16879.5 CCF52944.1 - 8.9e-78 261.9 0.0 5.5e-77 259.3 0.0 2.3 2 0 0 2 2 2 1 C-terminal domain of Sin3a protein PAH PF02671.21 CCF52944.1 - 2e-43 146.3 6.0 3.9e-18 65.3 0.0 3.9 3 0 0 3 3 3 3 Paired amphipathic helix repeat Sin3_corepress PF08295.12 CCF52944.1 - 2e-41 140.0 0.1 5e-41 138.7 0.1 1.7 1 0 0 1 1 1 1 Sin3 family co-repressor Ribosomal_S21e PF01249.18 CCF52945.1 - 1.2e-36 124.7 0.0 1.3e-36 124.6 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S21e MFS_1 PF07690.16 CCF52946.1 - 8.5e-32 110.4 32.2 8.5e-32 110.4 32.2 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily Cytochrom_C PF00034.21 CCF52947.1 - 4.2e-10 40.6 0.1 6.5e-10 40.0 0.1 1.3 1 1 0 1 1 1 1 Cytochrome c Cytochrome_CBB3 PF13442.6 CCF52947.1 - 2.3e-08 34.2 1.5 2.4e-07 31.0 1.5 2.0 1 1 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C550 PF14495.6 CCF52947.1 - 0.00033 20.4 0.9 0.0018 18.0 0.9 2.1 1 1 0 1 1 1 1 Cytochrome c-550 domain CCP_MauG PF03150.14 CCF52947.1 - 0.048 14.3 0.0 0.05 14.3 0.0 1.1 1 0 0 1 1 1 0 Di-haem cytochrome c peroxidase MARVEL PF01284.23 CCF52948.1 - 8.2e-06 25.9 19.7 9.8e-05 22.4 20.3 2.2 1 1 1 2 2 2 2 Membrane-associating domain Pox_A14 PF05767.12 CCF52948.1 - 0.031 14.4 0.3 7.5 6.8 0.0 2.4 2 0 0 2 2 2 0 Poxvirus virion envelope protein A14 Ribosomal_S4e PF00900.20 CCF52950.1 - 3.7e-36 122.9 0.3 7.9e-36 121.8 0.3 1.6 1 0 0 1 1 1 1 Ribosomal family S4e 40S_S4_C PF16121.5 CCF52950.1 - 2.8e-21 74.9 0.0 5.3e-21 74.0 0.0 1.5 1 0 0 1 1 1 1 40S ribosomal protein S4 C-terminus RS4NT PF08071.12 CCF52950.1 - 1.2e-07 31.7 0.1 2.3e-07 30.8 0.1 1.5 1 0 0 1 1 1 1 RS4NT (NUC023) domain KOW PF00467.29 CCF52950.1 - 6.4e-05 22.7 2.8 0.00027 20.8 2.8 2.2 1 0 0 1 1 1 1 KOW motif S4 PF01479.25 CCF52950.1 - 6.6e-05 22.6 0.0 0.00015 21.4 0.0 1.6 1 0 0 1 1 1 1 S4 domain HMG_box PF00505.19 CCF52951.1 - 1.7e-12 47.5 3.5 4.2e-12 46.3 3.5 1.7 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 CCF52951.1 - 2.3e-06 28.1 0.9 6.5e-06 26.7 0.9 1.8 1 0 0 1 1 1 1 HMG-box domain Cyclin PF08613.11 CCF52952.1 - 5.2e-37 127.7 11.6 2.7e-23 83.1 0.0 4.6 4 0 0 4 4 4 2 Cyclin Reprolysin_5 PF13688.6 CCF52953.1 - 2e-42 145.6 7.8 2e-42 145.6 7.8 2.1 2 0 0 2 2 2 1 Metallo-peptidase family M12 Reprolysin_4 PF13583.6 CCF52953.1 - 2.6e-39 135.0 2.7 5.9e-39 133.8 2.7 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.6 CCF52953.1 - 2.9e-39 135.0 4.3 6.2e-39 133.9 4.3 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Disintegrin PF00200.23 CCF52953.1 - 6.7e-16 58.9 26.1 6.7e-16 58.9 26.1 4.1 3 1 0 3 3 3 1 Disintegrin Reprolysin_3 PF13582.6 CCF52953.1 - 5.2e-13 49.6 0.0 1.7e-12 47.9 0.0 2.0 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin PF01421.19 CCF52953.1 - 1.2e-07 31.9 8.9 3.7e-05 23.7 8.9 3.0 1 1 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease Pep_M12B_propep PF01562.19 CCF52953.1 - 1.7e-07 31.6 0.7 5.9e-07 29.8 0.0 2.2 3 0 0 3 3 3 1 Reprolysin family propeptide ADAM_CR_2 PF17771.1 CCF52953.1 - 5.3e-05 23.7 10.9 5.3e-05 23.7 10.9 4.2 2 1 2 4 4 4 1 ADAM cysteine-rich domain Peptidase_M66 PF10462.9 CCF52953.1 - 0.047 12.6 0.1 0.078 11.9 0.1 1.3 1 0 0 1 1 1 0 Peptidase M66 Peptidase_M43 PF05572.13 CCF52953.1 - 9.6 6.1 6.8 0.33 10.9 0.4 1.9 2 0 0 2 2 2 0 Pregnancy-associated plasma protein-A CENP-T_C PF15511.6 CCF52954.1 - 7.6e-08 32.5 0.1 9.2e-08 32.2 0.1 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold TAF PF02969.17 CCF52954.1 - 0.00021 21.4 0.1 0.00032 20.8 0.1 1.5 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) CENP-S PF15630.6 CCF52954.1 - 0.00047 20.5 0.0 0.00062 20.1 0.0 1.3 1 1 0 1 1 1 1 CENP-S protein Histone PF00125.24 CCF52954.1 - 0.00062 20.1 0.1 0.0007 20.0 0.1 1.3 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 CCF52954.1 - 0.00091 19.5 0.1 0.0019 18.5 0.0 1.6 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 CCF52954.1 - 0.05 13.7 0.0 0.056 13.5 0.0 1.1 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit Histone PF00125.24 CCF52955.1 - 6.3e-51 172.2 3.3 7e-51 172.0 3.3 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.6 CCF52955.1 - 3.8e-05 24.0 0.0 5.7e-05 23.4 0.0 1.2 1 0 0 1 1 1 1 CENP-S protein CENP-T_C PF15511.6 CCF52955.1 - 0.0001 22.4 1.0 0.00012 22.2 0.1 1.6 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold PAF PF15715.5 CCF52955.1 - 0.00012 22.7 1.1 0.00014 22.4 1.1 1.2 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CBFD_NFYB_HMF PF00808.23 CCF52955.1 - 0.0008 19.6 0.1 0.0015 18.7 0.1 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Bromo_TP PF07524.13 CCF52955.1 - 0.063 13.3 0.1 0.1 12.6 0.1 1.4 1 0 0 1 1 1 0 Bromodomain associated TFIID-31kDa PF02291.15 CCF52955.1 - 0.073 13.1 0.3 0.12 12.4 0.1 1.4 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit Thiolase_N PF00108.23 CCF52956.1 - 2e-77 260.1 2.5 2.8e-77 259.6 2.5 1.2 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 CCF52956.1 - 4.1e-42 142.7 0.6 4.1e-42 142.7 0.6 1.7 2 0 0 2 2 2 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 CCF52956.1 - 0.0013 18.4 1.7 0.0075 15.9 0.2 2.8 3 0 0 3 3 3 1 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III_C PF08541.10 CCF52956.1 - 0.009 16.2 0.4 0.037 14.2 0.1 2.2 2 0 0 2 2 2 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal DUF2420 PF10336.9 CCF52957.1 - 4.3e-17 62.1 0.0 8.5e-17 61.1 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2420) FOXP-CC PF16159.5 CCF52959.1 - 0.0083 16.7 0.3 0.024 15.3 0.3 1.8 1 0 0 1 1 1 1 FOXP coiled-coil domain zf-C2H2 PF00096.26 CCF52959.1 - 0.058 13.9 0.3 0.14 12.7 0.3 1.7 1 0 0 1 1 1 0 Zinc finger, C2H2 type Cys_Met_Meta_PP PF01053.20 CCF52960.1 - 2.2e-54 184.5 0.0 8.6e-44 149.6 0.0 2.7 2 2 0 2 2 2 2 Cys/Met metabolism PLP-dependent enzyme PIF1 PF05970.14 CCF52961.1 - 2.2e-64 217.9 0.8 1.4e-61 208.7 0.8 2.2 1 1 0 1 1 1 1 PIF1-like helicase AAA_30 PF13604.6 CCF52961.1 - 4.8e-27 94.9 0.0 1e-26 93.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 CCF52961.1 - 2e-12 47.6 0.0 3.6e-12 46.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 CCF52961.1 - 6.1e-07 29.8 0.0 1.5e-06 28.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_7 PF12775.7 CCF52961.1 - 4.2e-05 23.1 0.0 0.00011 21.8 0.0 1.6 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_16 PF13191.6 CCF52961.1 - 9.6e-05 22.8 0.1 0.00029 21.3 0.1 1.9 1 1 0 1 1 1 1 AAA ATPase domain AAA_11 PF13086.6 CCF52961.1 - 0.0002 21.2 0.2 0.006 16.4 0.0 2.8 1 1 1 2 2 2 1 AAA domain T2SSE PF00437.20 CCF52961.1 - 0.00057 19.0 0.0 0.0011 18.1 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein Viral_helicase1 PF01443.18 CCF52961.1 - 0.00058 19.7 0.1 0.087 12.6 0.1 2.8 2 1 0 2 2 2 1 Viral (Superfamily 1) RNA helicase AAA PF00004.29 CCF52961.1 - 0.00067 20.1 0.0 0.0019 18.7 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ATPase_2 PF01637.18 CCF52961.1 - 0.0032 17.4 0.4 0.028 14.3 0.3 2.2 1 1 0 1 1 1 1 ATPase domain predominantly from Archaea ABC_tran PF00005.27 CCF52961.1 - 0.0041 17.6 0.0 0.021 15.4 0.0 2.1 2 0 0 2 2 1 1 ABC transporter UvrD_C_2 PF13538.6 CCF52961.1 - 0.0044 16.8 0.1 0.015 15.1 0.1 1.9 1 1 0 1 1 1 1 UvrD-like helicase C-terminal domain DUF2075 PF09848.9 CCF52961.1 - 0.0054 16.0 0.1 0.015 14.6 0.1 1.8 1 1 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) Mg_chelatase PF01078.21 CCF52961.1 - 0.0082 15.5 0.1 0.016 14.6 0.1 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI NACHT PF05729.12 CCF52961.1 - 0.0083 16.1 0.0 0.017 15.1 0.0 1.5 1 0 0 1 1 1 1 NACHT domain RNA_helicase PF00910.22 CCF52961.1 - 0.0092 16.4 0.0 0.063 13.7 0.0 2.4 2 1 0 2 2 2 1 RNA helicase TrwB_AAD_bind PF10412.9 CCF52961.1 - 0.014 14.3 0.0 0.033 13.1 0.0 1.6 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain AAA_32 PF13654.6 CCF52961.1 - 0.015 14.1 0.0 0.028 13.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.6 CCF52961.1 - 0.016 15.3 0.0 0.083 12.9 0.0 2.1 1 1 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 CCF52961.1 - 0.02 14.6 0.1 0.066 12.9 0.1 1.9 1 1 0 1 1 1 0 Sigma-54 interaction domain AAA_5 PF07728.14 CCF52961.1 - 0.022 14.7 0.6 0.44 10.5 0.2 2.8 2 1 0 2 2 1 0 AAA domain (dynein-related subfamily) NB-ARC PF00931.22 CCF52961.1 - 0.027 13.7 0.1 0.045 12.9 0.1 1.3 1 0 0 1 1 1 0 NB-ARC domain Herpes_Helicase PF02689.14 CCF52961.1 - 0.029 12.3 0.0 0.19 9.6 0.0 2.0 2 0 0 2 2 2 0 Helicase SH3_13 PF18335.1 CCF52961.1 - 0.037 13.9 0.3 0.19 11.6 0.1 2.2 2 0 0 2 2 2 0 ATP-dependent RecD-like DNA helicase SH3 domain PhoH PF02562.16 CCF52961.1 - 0.039 13.4 0.0 0.11 11.9 0.0 1.7 2 0 0 2 2 1 0 PhoH-like protein TniB PF05621.11 CCF52961.1 - 0.045 13.2 0.0 0.083 12.3 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein Helicase_RecD PF05127.14 CCF52961.1 - 0.049 13.5 0.3 0.15 11.9 0.3 1.8 1 1 0 1 1 1 0 Helicase MMR_HSR1 PF01926.23 CCF52961.1 - 0.054 13.6 0.0 0.13 12.4 0.0 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase UvrD-helicase PF00580.21 CCF52961.1 - 0.055 13.0 0.4 0.12 11.9 0.1 1.8 2 0 0 2 2 2 0 UvrD/REP helicase N-terminal domain DUF815 PF05673.13 CCF52961.1 - 0.057 12.6 0.0 0.14 11.3 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_29 PF13555.6 CCF52961.1 - 0.077 12.7 0.7 0.37 10.6 0.0 2.2 2 0 0 2 2 2 0 P-loop containing region of AAA domain NTPase_1 PF03266.15 CCF52961.1 - 0.081 12.8 0.0 0.53 10.2 0.0 2.2 2 0 0 2 2 2 0 NTPase RsgA_GTPase PF03193.16 CCF52961.1 - 0.082 12.8 0.0 0.17 11.8 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase DUF5605 PF18310.1 CCF52961.1 - 0.096 12.6 0.0 0.23 11.4 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5605) IstB_IS21 PF01695.17 CCF52961.1 - 0.14 11.9 0.0 11 5.8 0.0 2.4 2 0 0 2 2 2 0 IstB-like ATP binding protein CobA_CobO_BtuR PF02572.15 CCF52961.1 - 0.14 12.4 0.0 0.31 11.3 0.0 1.5 1 0 0 1 1 1 0 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP TsaE PF02367.17 CCF52961.1 - 0.18 11.8 0.0 0.41 10.7 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE DnaJ-X PF14308.6 CCF52962.1 - 2.2e-65 220.0 1.1 2.2e-65 220.0 1.1 2.8 2 1 0 2 2 2 1 X-domain of DnaJ-containing DnaJ PF00226.31 CCF52962.1 - 9.7e-19 67.3 0.2 3.5e-18 65.5 0.2 2.0 1 0 0 1 1 1 1 DnaJ domain PAT1 PF09770.9 CCF52962.1 - 0.0017 16.7 3.1 0.0022 16.4 3.1 1.1 1 0 0 1 1 1 1 Topoisomerase II-associated protein PAT1 Chon_Sulph_att PF06566.11 CCF52962.1 - 0.096 12.5 0.1 0.096 12.5 0.1 2.1 2 0 0 2 2 2 0 Chondroitin sulphate attachment domain PA26 PF04636.13 CCF52962.1 - 2.4 7.0 6.2 3.4 6.5 6.2 1.2 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Presenilin PF01080.17 CCF52962.1 - 8.9 5.0 7.9 15 4.2 7.9 1.3 1 0 0 1 1 1 0 Presenilin GATase PF00117.28 CCF52963.1 - 1.7e-05 24.7 0.1 4.9e-05 23.2 0.0 1.7 2 0 0 2 2 2 1 Glutamine amidotransferase class-I zf-TFIIIC PF12660.7 CCF52964.1 - 6.2e-10 38.9 2.1 1.2e-09 38.0 1.2 1.9 2 0 0 2 2 2 1 Putative zinc-finger of transcription factor IIIC complex TFIIIC_delta PF12657.7 CCF52964.1 - 2.9e-08 33.8 0.0 8.4e-08 32.4 0.0 1.8 1 0 0 1 1 1 1 Transcription factor IIIC subunit delta N-term ThiF PF00899.21 CCF52965.1 - 9.8e-57 192.1 0.0 1.6e-56 191.4 0.0 1.3 1 0 0 1 1 1 1 ThiF family RabGAP-TBC PF00566.18 CCF52965.1 - 1.6e-32 112.9 0.3 2.9e-16 59.8 0.1 2.4 2 0 0 2 2 2 2 Rab-GTPase-TBC domain Rhodanese PF00581.20 CCF52965.1 - 3.1e-05 24.4 0.0 0.0011 19.5 0.0 3.1 2 1 0 2 2 2 1 Rhodanese-like domain Shikimate_DH PF01488.20 CCF52965.1 - 0.00066 19.8 0.0 0.0017 18.4 0.0 1.7 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase NAD_binding_7 PF13241.6 CCF52965.1 - 0.015 15.8 0.0 0.043 14.2 0.0 1.8 1 0 0 1 1 1 0 Putative NAD(P)-binding AlaDh_PNT_C PF01262.21 CCF52965.1 - 0.03 13.6 0.4 0.075 12.3 0.1 1.7 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain Sacchrp_dh_NADP PF03435.18 CCF52965.1 - 0.16 12.2 2.7 0.26 11.5 0.6 2.4 2 1 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain YTH PF04146.15 CCF52966.1 - 4.7e-40 137.2 0.0 1.2e-39 135.9 0.0 1.7 1 0 0 1 1 1 1 YT521-B-like domain PapG_N PF03627.13 CCF52966.1 - 0.13 11.9 0.0 0.2 11.3 0.0 1.2 1 0 0 1 1 1 0 PapG carbohydrate binding domain SIS PF01380.22 CCF52967.1 - 3.5e-17 62.5 0.0 1.3e-16 60.6 0.0 1.9 2 0 0 2 2 2 1 SIS domain SIS_2 PF13580.6 CCF52967.1 - 4.7e-07 29.9 0.1 0.034 14.2 0.1 2.6 1 1 1 2 2 2 2 SIS domain Ashwin PF15323.6 CCF52967.1 - 1.9 8.5 7.5 3.7 7.5 7.5 1.4 1 0 0 1 1 1 0 Developmental protein MFS_1 PF07690.16 CCF52968.1 - 1.2e-39 136.3 38.0 1.2e-39 136.3 38.0 1.8 1 1 1 2 2 2 1 Major Facilitator Superfamily MFS_4 PF06779.14 CCF52968.1 - 9.8e-07 28.4 8.3 9.8e-07 28.4 8.3 2.8 3 0 0 3 3 3 1 Uncharacterised MFS-type transporter YbfB OATP PF03137.20 CCF52968.1 - 0.09 11.0 16.2 0.07 11.4 3.7 2.6 1 1 1 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family CDC45 PF02724.14 CCF52968.1 - 0.11 10.7 0.6 0.15 10.3 0.6 1.1 1 0 0 1 1 1 0 CDC45-like protein DNA_pol_phi PF04931.13 CCF52968.1 - 3.3 5.7 4.1 4.8 5.2 4.1 1.2 1 0 0 1 1 1 0 DNA polymerase phi DnaJ_C PF01556.18 CCF52969.1 - 1.9e-40 138.3 0.7 2.7e-40 137.9 0.7 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 CCF52969.1 - 1.7e-20 72.9 1.7 2.9e-20 72.2 1.7 1.4 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 CCF52969.1 - 4.1e-17 62.3 20.4 6.7e-17 61.6 20.4 1.3 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 CCF52969.1 - 0.0093 15.9 10.8 0.052 13.5 1.7 2.6 2 0 0 2 2 2 2 Tryptophan RNA-binding attenuator protein inhibitory protein HypA PF01155.19 CCF52969.1 - 0.32 11.0 11.1 3.1 7.8 3.6 2.3 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA TackOD1 PF18551.1 CCF52969.1 - 0.42 10.3 7.0 0.82 9.3 2.1 2.2 1 1 1 2 2 2 0 Thaumarchaeal output domain 1 DUF2614 PF11023.8 CCF52969.1 - 9.1 6.4 6.1 4 7.6 0.8 2.1 1 1 1 2 2 2 0 Zinc-ribbon containing domain Peptidase_A22B PF04258.13 CCF52970.1 - 1.7e-78 264.1 5.9 2.3e-78 263.6 5.9 1.1 1 0 0 1 1 1 1 Signal peptide peptidase SPP PF06550.11 CCF52970.1 - 4.1e-07 29.8 5.0 9e-07 28.6 5.0 1.5 1 0 0 1 1 1 1 Signal-peptide peptidase, presenilin aspartyl protease FAM176 PF14851.6 CCF52970.1 - 7.7e-05 22.4 2.5 0.045 13.4 0.1 2.4 2 0 0 2 2 2 2 FAM176 family DUF4834 PF16118.5 CCF52970.1 - 0.053 14.5 0.9 17 6.5 1.6 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) tRNA_synt_1c_R2 PF04557.15 CCF52970.1 - 0.4 11.6 0.1 0.4 11.6 0.1 2.2 2 0 0 2 2 2 0 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 CENP-B_dimeris PF09026.10 CCF52970.1 - 0.53 10.7 10.2 0.15 12.5 0.8 2.3 2 0 0 2 2 2 0 Centromere protein B dimerisation domain ESSS PF10183.9 CCF52970.1 - 1.4 9.2 4.8 2.9 8.1 0.0 2.7 2 1 1 3 3 3 0 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) Ferric_reduct PF01794.19 CCF52971.1 - 2.5e-18 66.4 10.1 2.5e-18 66.4 10.1 1.9 2 0 0 2 2 2 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.12 CCF52971.1 - 1.7e-16 60.3 0.0 5.4e-14 52.2 0.0 2.4 1 1 0 1 1 1 1 FAD-binding domain NAD_binding_6 PF08030.12 CCF52971.1 - 7.6e-13 48.9 0.0 5.4e-10 39.6 0.0 2.3 2 0 0 2 2 2 2 Ferric reductase NAD binding domain ESSS PF10183.9 CCF52971.1 - 6.6 7.0 5.5 1.5 9.0 0.0 2.7 3 0 0 3 3 3 0 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) Gpi16 PF04113.14 CCF52972.1 - 6.6e-111 371.5 0.0 5.9e-92 308.9 0.0 3.5 2 1 0 2 2 2 2 Gpi16 subunit, GPI transamidase component PRIMA1 PF16101.5 CCF52972.1 - 0.0045 17.0 1.7 0.012 15.7 1.7 1.7 1 0 0 1 1 1 1 Proline-rich membrane anchor 1 CAP_N PF01213.19 CCF52972.1 - 0.07 12.6 8.0 0.15 11.5 8.0 1.5 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal DUF4344 PF14247.6 CCF52972.1 - 0.18 11.4 0.0 0.32 10.6 0.0 1.3 1 0 0 1 1 1 0 Putative metallopeptidase Mito_fiss_reg PF05308.11 CCF52972.1 - 0.56 10.2 4.3 0.33 11.0 2.0 1.8 2 0 0 2 2 2 0 Mitochondrial fission regulator zf-met2 PF12907.7 CCF52973.1 - 3.5e-09 36.7 1.1 6.4e-09 35.8 1.1 1.4 1 0 0 1 1 1 1 Zinc-binding 4F5 PF04419.14 CCF52973.1 - 1.6e-07 32.1 14.0 2.2e-07 31.6 14.0 1.2 1 0 0 1 1 1 1 4F5 protein family Eapp_C PF10238.9 CCF52973.1 - 0.04 14.0 0.7 0.058 13.5 0.7 1.2 1 0 0 1 1 1 0 E2F-associated phosphoprotein SMI1_KNR4 PF09346.10 CCF52974.1 - 2.6e-27 95.8 0.0 4.5e-27 95.1 0.0 1.4 1 0 0 1 1 1 1 SMI1 / KNR4 family (SUKH-1) Glyco_hydro_25 PF01183.20 CCF52975.1 - 3.3e-44 151.2 0.5 4.2e-44 150.9 0.5 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 25 Glyco_hydro_63 PF03200.16 CCF52976.1 - 9.2e-167 555.7 0.1 7.3e-166 552.7 0.1 1.9 1 1 0 1 1 1 1 Glycosyl hydrolase family 63 C-terminal domain Glyco_hydro_63N PF16923.5 CCF52976.1 - 1.2e-66 225.1 0.0 2.3e-66 224.1 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 63 N-terminal domain Trehalase PF01204.18 CCF52976.1 - 5.3e-09 35.4 0.2 8.1e-09 34.8 0.2 1.2 1 0 0 1 1 1 1 Trehalase Bac_rhamnosid6H PF17389.2 CCF52976.1 - 0.024 13.9 0.2 0.059 12.6 0.2 1.6 1 1 0 1 1 1 0 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain XPA_C PF05181.12 CCF52977.1 - 1.7e-23 82.3 1.8 3.1e-23 81.5 1.8 1.4 1 0 0 1 1 1 1 XPA protein C-terminus DUF3027 PF11228.8 CCF52977.1 - 0.018 15.0 0.7 6.2 6.8 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3027) DZR PF12773.7 CCF52977.1 - 0.26 11.3 2.9 17 5.5 0.9 2.5 2 0 0 2 2 2 0 Double zinc ribbon DUF1451 PF07295.11 CCF52977.1 - 5.1 7.1 8.9 0.35 10.9 0.2 2.6 2 1 0 2 2 2 0 Zinc-ribbon containing domain Sec16_C PF12931.7 CCF52978.1 - 9.4e-105 350.6 0.0 1.5e-104 349.9 0.0 1.3 1 0 0 1 1 1 1 Sec23-binding domain of Sec16 Sec16 PF12932.7 CCF52978.1 - 3.3e-26 92.2 0.0 1.1e-25 90.5 0.0 2.0 1 0 0 1 1 1 1 Vesicle coat trafficking protein Sec16 mid-region TMEM171 PF15471.6 CCF52978.1 - 0.055 12.5 3.6 0.24 10.4 3.6 2.1 1 0 0 1 1 1 0 Transmembrane protein family 171 CLTH PF10607.9 CCF52979.1 - 2.6e-16 59.9 0.0 4.5e-16 59.1 0.0 1.4 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain zf-RING_UBOX PF13445.6 CCF52979.1 - 3.1e-08 33.5 0.4 5.2e-08 32.8 0.4 1.4 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 CCF52979.1 - 1.6e-05 24.8 0.8 2.6e-05 24.1 0.8 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 CCF52979.1 - 7.4e-05 22.8 0.4 0.00015 21.8 0.4 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.6 CCF52979.1 - 0.0022 17.8 0.7 0.0037 17.1 0.7 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CCF52979.1 - 0.0025 18.1 0.7 0.0041 17.4 0.7 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 CCF52979.1 - 0.0043 16.9 1.2 0.0077 16.1 1.2 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 CCF52979.1 - 0.0082 16.0 0.6 0.017 15.0 0.6 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 CCF52979.1 - 0.03 14.2 1.7 0.052 13.4 1.7 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) PheRS_DBD1 PF18552.1 CCF52979.1 - 0.14 11.9 0.2 0.42 10.4 0.0 1.9 2 0 0 2 2 2 0 PheRS DNA binding domain 1 zf-C2HC5 PF06221.13 CCF52979.1 - 0.19 11.8 0.3 0.39 10.7 0.3 1.4 1 0 0 1 1 1 0 Putative zinc finger motif, C2HC5-type zf-C3HC4_5 PF17121.5 CCF52979.1 - 0.37 10.7 1.9 3 7.8 0.3 2.4 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) RVT_2 PF07727.14 CCF52980.1 - 3.6e-19 69.4 0.0 2.1e-12 47.2 0.0 2.3 2 0 0 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) Metallophos PF00149.28 CCF52981.1 - 2.6e-11 44.4 0.3 4.7e-11 43.6 0.3 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 CCF52981.1 - 1.8e-07 31.5 1.1 4.6e-06 26.9 1.1 2.3 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain RHD3 PF05879.12 CCF52982.1 - 7.2e-249 827.9 1.1 9e-249 827.5 1.1 1.0 1 0 0 1 1 1 1 Root hair defective 3 GTP-binding protein (RHD3) GBP PF02263.19 CCF52982.1 - 4.4e-07 29.4 1.6 6.2e-07 28.9 0.1 2.0 2 0 0 2 2 2 1 Guanylate-binding protein, N-terminal domain MMR_HSR1 PF01926.23 CCF52982.1 - 5.5e-06 26.4 0.1 1.9e-05 24.7 0.0 2.0 2 0 0 2 2 2 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 CCF52982.1 - 0.00013 22.1 0.0 0.00031 20.8 0.0 1.7 1 0 0 1 1 1 1 Dynamin family AAA_28 PF13521.6 CCF52982.1 - 0.007 16.6 0.0 0.021 15.1 0.0 1.8 1 0 0 1 1 1 1 AAA domain Roc PF08477.13 CCF52982.1 - 0.068 13.4 0.9 0.21 11.8 0.1 2.1 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 CCF52982.1 - 0.073 12.7 0.0 0.22 11.1 0.0 1.7 1 0 0 1 1 1 0 Ras family TK PF00265.18 CCF52982.1 - 0.14 12.0 0.1 0.34 10.8 0.1 1.6 1 0 0 1 1 1 0 Thymidine kinase FeoB_N PF02421.18 CCF52982.1 - 0.15 11.6 0.0 0.28 10.7 0.0 1.4 1 0 0 1 1 1 0 Ferrous iron transport protein B Insulin_TMD PF17870.1 CCF52982.1 - 0.27 11.3 0.6 0.57 10.3 0.6 1.5 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment NLE PF08154.12 CCF52983.1 - 7.6e-18 64.8 0.0 1.4e-17 64.0 0.0 1.5 1 0 0 1 1 1 1 NLE (NUC135) domain WD40 PF00400.32 CCF52983.1 - 1.2e-12 48.1 21.9 0.11 13.4 0.1 8.1 8 1 0 8 8 8 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF52983.1 - 6.2e-05 23.2 0.5 0.086 13.1 0.0 3.1 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 CCF52983.1 - 0.017 15.0 0.0 2.7 7.8 0.0 2.6 2 1 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A DUF3565 PF12088.8 CCF52983.1 - 0.23 11.4 0.4 0.57 10.2 0.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3565) Yippee-Mis18 PF03226.14 CCF52984.1 - 4e-12 46.3 0.8 5.1e-12 45.9 0.8 1.1 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly RIG-I_C-RD PF11648.8 CCF52984.1 - 0.051 13.8 0.5 0.091 13.0 0.5 1.5 1 1 0 1 1 1 0 C-terminal domain of RIG-I SKG6 PF08693.10 CCF52985.1 - 2.2e-08 33.3 0.3 7.3e-08 31.7 0.3 1.9 1 0 0 1 1 1 1 Transmembrane alpha-helix domain TMEM51 PF15345.6 CCF52985.1 - 0.0048 16.8 8.3 0.0058 16.5 0.3 3.1 3 0 0 3 3 3 2 Transmembrane protein 51 DUF4448 PF14610.6 CCF52985.1 - 0.011 15.5 0.0 0.022 14.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) EOS1 PF12326.8 CCF52985.1 - 0.044 13.7 0.2 0.99 9.3 0.2 2.5 1 1 0 1 1 1 0 N-glycosylation protein HAMP PF00672.25 CCF52986.1 - 6.5e-37 125.7 19.4 4.3e-08 33.4 0.4 9.0 8 2 1 9 9 9 6 HAMP domain HATPase_c PF02518.26 CCF52986.1 - 6.2e-28 97.6 0.1 1.9e-27 96.0 0.1 2.0 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 CCF52986.1 - 2.3e-24 85.7 0.7 1.6e-23 83.0 0.8 2.4 2 0 0 2 2 2 1 Response regulator receiver domain HisKA PF00512.25 CCF52986.1 - 1e-15 57.5 3.0 2.1e-15 56.5 0.3 3.3 4 0 0 4 4 4 1 His Kinase A (phospho-acceptor) domain DUF3829 PF12889.7 CCF52986.1 - 0.047 13.2 0.9 13 5.1 0.0 3.8 4 0 0 4 4 4 0 Protein of unknown function (DUF3829) SpoIIID PF12116.8 CCF52986.1 - 0.27 11.4 1.3 25 5.1 0.0 4.3 6 0 0 6 6 6 0 Stage III sporulation protein D Rab5-bind PF09311.11 CCF52986.1 - 0.59 9.5 9.0 5.7 6.2 0.1 4.3 3 2 1 4 4 4 0 Rabaptin-like protein ApoLp-III PF07464.11 CCF52986.1 - 4.7 7.3 17.8 7.8 6.6 0.1 6.3 4 2 1 7 7 7 0 Apolipophorin-III precursor (apoLp-III) Glyco_hydro_31 PF01055.26 CCF52987.1 - 4.6e-125 418.3 5.2 7.3e-125 417.6 5.2 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 NtCtMGAM_N PF16863.5 CCF52987.1 - 3.3e-26 91.7 0.1 9.2e-26 90.3 0.1 1.8 1 0 0 1 1 1 1 N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase Gal_mutarotas_2 PF13802.6 CCF52987.1 - 0.046 14.0 0.1 0.14 12.5 0.1 1.9 1 0 0 1 1 1 0 Galactose mutarotase-like Pkinase PF00069.25 CCF52988.1 - 9.8e-57 192.3 0.1 1.9e-35 122.6 0.1 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CCF52988.1 - 2.8e-24 85.8 0.3 1.8e-16 60.2 0.1 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase DUF3439 PF11921.8 CCF52988.1 - 0.0052 16.7 3.5 0.011 15.7 3.5 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3439) APH PF01636.23 CCF52988.1 - 0.0057 16.6 0.8 0.062 13.2 0.1 2.7 2 0 0 2 2 2 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 CCF52988.1 - 0.0065 15.5 0.1 0.01 14.8 0.1 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 CCF52988.1 - 0.028 13.7 0.1 0.089 12.1 0.0 1.7 2 0 0 2 2 2 0 Kinase-like Pkinase_C PF00433.24 CCF52988.1 - 0.045 14.4 0.2 0.41 11.4 0.0 2.7 2 0 0 2 2 2 0 Protein kinase C terminal domain RIO1 PF01163.22 CCF52988.1 - 0.084 12.5 0.8 1.1 8.9 0.0 2.4 2 0 0 2 2 2 0 RIO1 family SSP160 PF06933.11 CCF52988.1 - 0.22 9.7 7.5 0.34 9.1 7.5 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 FSA_C PF10479.9 CCF52988.1 - 0.32 9.1 3.6 0.51 8.4 3.6 1.2 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus PhyH PF05721.13 CCF52990.1 - 4.6e-45 154.5 0.0 6.3e-45 154.0 0.0 1.2 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) 2OG-FeII_Oxy_5 PF13759.6 CCF52990.1 - 0.0033 17.8 0.0 0.008 16.6 0.0 1.7 1 0 0 1 1 1 1 Putative 2OG-Fe(II) oxygenase OPT PF03169.15 CCF52991.1 - 2.4e-141 472.4 11.4 2.9e-141 472.2 11.4 1.1 1 0 0 1 1 1 1 OPT oligopeptide transporter protein PBP1_TM PF14812.6 CCF52991.1 - 0.25 11.7 0.1 0.25 11.7 0.1 2.1 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Phage_holin_2_1 PF04971.12 CCF52991.1 - 0.38 10.8 6.6 1.6 8.8 0.0 3.8 3 0 0 3 3 3 0 Bacteriophage P21 holin S Peptidase_U4 PF03419.13 CCF52991.1 - 0.53 9.5 4.4 0.73 9.1 0.3 2.6 2 0 0 2 2 2 0 Sporulation factor SpoIIGA AtpR PF12966.7 CCF52991.1 - 4.7 7.7 8.5 1.7 9.2 0.2 3.4 3 0 0 3 3 3 0 N-ATPase, AtpR subunit Topoisom_bac PF01131.20 CCF52992.1 - 6.9e-101 338.2 0.0 8.3e-101 338.0 0.0 1.1 1 0 0 1 1 1 1 DNA topoisomerase zf-GRF PF06839.12 CCF52992.1 - 2.9e-25 88.1 11.1 2.2e-13 50.1 1.9 2.8 2 0 0 2 2 2 2 GRF zinc finger Toprim PF01751.22 CCF52992.1 - 9e-20 70.8 0.0 5.1e-19 68.4 0.0 2.1 2 0 0 2 2 2 1 Toprim domain zf-CCHC PF00098.23 CCF52992.1 - 1.1e-13 50.6 14.8 1.2e-07 31.5 3.5 3.0 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_3 PF13917.6 CCF52992.1 - 1.8e-07 31.0 4.9 0.0015 18.4 0.3 2.8 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_2 PF13696.6 CCF52992.1 - 7.1e-07 28.9 12.4 0.0017 18.1 1.8 2.8 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_5 PF14787.6 CCF52992.1 - 1.5e-05 24.6 11.9 0.0085 15.8 1.8 2.6 2 0 0 2 2 2 2 GAG-polyprotein viral zinc-finger eIF3g PF12353.8 CCF52992.1 - 0.31 11.4 3.8 5.8 7.3 0.1 2.5 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit G HLH PF00010.26 CCF52993.1 - 1.1e-09 38.1 0.0 3.3e-09 36.6 0.0 1.9 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain FAM76 PF16046.5 CCF52993.1 - 0.33 10.3 23.3 4 6.7 4.9 3.3 3 0 0 3 3 3 0 FAM76 protein Porph_ging PF09697.10 CCF52993.1 - 5.4 7.6 12.8 0.19 12.3 1.7 2.9 2 0 0 2 2 2 0 Protein of unknown function (Porph_ging) DUF4770 PF15994.5 CCF52993.1 - 5.7 7.1 21.1 0.48 10.6 4.5 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4770) Inositol_P PF00459.25 CCF52994.1 - 2.3e-68 230.6 0.1 2.7e-68 230.4 0.1 1.0 1 0 0 1 1 1 1 Inositol monophosphatase family MIT PF04212.18 CCF52995.1 - 0.25 11.4 0.1 0.25 11.4 0.1 2.6 3 0 0 3 3 3 0 MIT (microtubule interacting and transport) domain Dicty_REP PF05086.12 CCF52995.1 - 1.6 6.6 4.3 2.6 5.9 4.3 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Pkinase PF00069.25 CCF52996.1 - 1.4e-19 70.5 0.0 1.6e-17 63.8 0.0 3.1 3 0 0 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF52996.1 - 1.9e-07 30.6 0.0 7.9e-07 28.6 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 CCF52996.1 - 0.0035 17.3 0.8 0.0047 16.9 0.0 1.7 2 0 0 2 2 2 1 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 CCF52996.1 - 0.0085 15.2 0.0 0.013 14.6 0.0 1.1 1 0 0 1 1 1 1 Seadornavirus VP7 Kdo PF06293.14 CCF52996.1 - 0.019 14.3 0.0 0.035 13.5 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 CCF52996.1 - 0.17 11.4 0.0 0.35 10.4 0.0 1.4 1 0 0 1 1 1 0 RIO1 family Caleosin PF05042.13 CCF52997.1 - 4.6e-70 234.9 0.1 5.8e-70 234.6 0.1 1.1 1 0 0 1 1 1 1 Caleosin related protein Ras PF00071.22 CCF52998.1 - 1.4e-20 73.6 0.0 1.9e-20 73.1 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CCF52998.1 - 1.2e-11 44.9 0.0 1.8e-11 44.3 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase AAA_24 PF13479.6 CCF52998.1 - 0.0017 18.1 0.1 0.0086 15.8 0.1 1.9 2 0 0 2 2 2 1 AAA domain Gtr1_RagA PF04670.12 CCF52998.1 - 0.0019 17.6 0.0 0.0035 16.7 0.0 1.5 2 0 0 2 2 1 1 Gtr1/RagA G protein conserved region Mg_chelatase PF01078.21 CCF52998.1 - 0.0087 15.5 0.0 0.013 14.9 0.0 1.3 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI NACHT PF05729.12 CCF52998.1 - 0.0095 15.9 0.1 0.023 14.6 0.0 1.6 2 0 0 2 2 2 1 NACHT domain AAA_22 PF13401.6 CCF52998.1 - 0.011 16.0 0.0 0.026 14.8 0.0 1.9 1 1 0 1 1 1 0 AAA domain DUF2791 PF10923.8 CCF52998.1 - 0.011 14.6 0.0 0.022 13.7 0.1 1.4 2 0 0 2 2 2 0 P-loop Domain of unknown function (DUF2791) KAP_NTPase PF07693.14 CCF52998.1 - 0.013 14.8 0.0 0.013 14.8 0.0 1.2 1 0 0 1 1 1 0 KAP family P-loop domain AAA_5 PF07728.14 CCF52998.1 - 0.014 15.4 0.0 0.021 14.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Zeta_toxin PF06414.12 CCF52998.1 - 0.016 14.5 0.0 0.031 13.6 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin TsaE PF02367.17 CCF52998.1 - 0.021 14.8 0.1 0.046 13.7 0.1 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_25 PF13481.6 CCF52998.1 - 0.03 13.9 0.1 0.039 13.5 0.1 1.4 1 1 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 CCF52998.1 - 0.033 13.9 0.2 0.062 13.0 0.2 1.5 1 1 0 1 1 1 0 Sigma-54 interaction domain Arf PF00025.21 CCF52998.1 - 0.033 13.6 0.0 0.041 13.3 0.0 1.3 1 0 0 1 1 1 0 ADP-ribosylation factor family Sigma54_activ_2 PF14532.6 CCF52998.1 - 0.043 13.9 0.0 0.071 13.2 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_16 PF13191.6 CCF52998.1 - 0.045 14.1 0.0 0.062 13.7 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain ATP_bind_1 PF03029.17 CCF52998.1 - 0.054 13.3 0.1 0.33 10.7 0.1 2.0 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein PRK PF00485.18 CCF52998.1 - 0.064 13.0 0.0 0.098 12.4 0.0 1.3 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family AAA_18 PF13238.6 CCF52998.1 - 0.086 13.4 0.6 0.44 11.1 0.1 2.1 2 1 0 2 2 2 0 AAA domain Septin PF00735.18 CCF52998.1 - 0.091 12.0 0.1 0.17 11.1 0.1 1.4 1 0 0 1 1 1 0 Septin MMR_HSR1 PF01926.23 CCF52998.1 - 0.11 12.6 0.0 0.23 11.6 0.0 1.7 1 1 0 1 1 1 0 50S ribosome-binding GTPase G-alpha PF00503.20 CCF52998.1 - 0.11 11.6 0.1 0.17 11.0 0.1 1.3 1 0 0 1 1 1 0 G-protein alpha subunit MMR_HSR1_Xtn PF16897.5 CCF52998.1 - 0.13 12.3 0.1 15 5.7 0.0 2.3 2 0 0 2 2 2 0 C-terminal region of MMR_HSR1 domain NTPase_1 PF03266.15 CCF52998.1 - 0.16 11.9 0.3 0.28 11.1 0.3 1.4 1 0 0 1 1 1 0 NTPase Pox_A32 PF04665.12 CCF52998.1 - 0.19 11.2 0.0 0.27 10.6 0.0 1.2 1 0 0 1 1 1 0 Poxvirus A32 protein HbrB PF08539.11 CCF52999.1 - 2e-53 180.9 0.0 3.7e-53 180.0 0.0 1.5 1 0 0 1 1 1 1 HbrB-like His_Phos_1 PF00300.22 CCF52999.1 - 4.6e-36 124.3 0.0 8.3e-36 123.5 0.0 1.4 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Glyco_hydro_18 PF00704.28 CCF53000.1 - 9.6e-16 58.4 0.1 1.3e-15 57.9 0.1 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 DNA_pol_E_B PF04042.16 CCF53001.1 - 6.9e-46 156.3 0.1 1.1e-45 155.6 0.1 1.3 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B ADH_zinc_N PF00107.26 CCF53002.1 - 0.0017 18.3 0.0 0.0021 18.0 0.0 1.1 1 0 0 1 1 1 1 Zinc-binding dehydrogenase AMNp_N PF10423.9 CCF53002.1 - 0.095 12.3 0.0 0.11 12.1 0.0 1.3 1 1 0 1 1 1 0 Bacterial AMP nucleoside phosphorylase N-terminus DNase_NucA_NucB PF14040.6 CCF53003.1 - 2.4e-24 85.9 2.9 4.5e-24 85.1 2.9 1.4 1 0 0 1 1 1 1 Deoxyribonuclease NucA/NucB OPT PF03169.15 CCF53004.1 - 2.2e-97 327.2 43.8 2.5e-97 327.0 43.8 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein DUF21 PF01595.20 CCF53004.1 - 4.6 6.9 6.9 3.7 7.2 0.5 3.1 2 1 1 3 3 3 0 Cyclin M transmembrane N-terminal domain Fungal_trans_2 PF11951.8 CCF53006.1 - 1e-15 57.4 0.0 2.7e-15 56.1 0.0 1.6 2 0 0 2 2 2 1 Fungal specific transcription factor domain DUF2678 PF10856.8 CCF53006.1 - 0.05 13.5 0.1 0.11 12.4 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2678) Aldedh PF00171.22 CCF53007.1 - 2.8e-179 596.5 0.2 3.2e-179 596.3 0.2 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family UDG PF03167.19 CCF53008.1 - 2e-17 63.6 0.0 4.5e-09 36.5 0.0 2.4 2 0 0 2 2 2 2 Uracil DNA glycosylase superfamily RVT_2 PF07727.14 CCF53009.1 - 0.00027 20.6 0.0 0.00046 19.9 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF953 PF06110.11 CCF53010.1 - 7.9e-16 57.7 0.0 8.5e-16 57.6 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF953) Thioredoxin PF00085.20 CCF53010.1 - 0.00049 20.0 0.2 0.00078 19.4 0.2 1.4 1 1 0 1 1 1 1 Thioredoxin Thioredoxin_9 PF14595.6 CCF53010.1 - 0.0014 18.4 0.0 0.0016 18.2 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_3 PF13192.6 CCF53010.1 - 0.015 15.3 0.1 0.054 13.6 0.0 1.9 2 1 0 2 2 2 0 Thioredoxin domain Thioredoxin_2 PF13098.6 CCF53010.1 - 0.017 15.6 0.2 0.097 13.1 0.2 1.9 1 1 0 1 1 1 0 Thioredoxin-like domain COPI_assoc PF08507.10 CCF53012.1 - 0.44 10.6 6.1 1 9.4 6.1 1.5 1 0 0 1 1 1 0 COPI associated protein R3H-assoc PF13902.6 CCF53013.1 - 0.011 16.1 0.0 0.011 16.1 0.0 3.1 3 1 0 3 3 3 0 R3H-associated N-terminal domain Ribosomal_L6 PF00347.23 CCF53014.1 - 3.8e-20 72.3 0.0 2.6e-10 40.8 0.0 2.9 3 0 0 3 3 3 2 Ribosomal protein L6 Ribosomal_L34e PF01199.18 CCF53015.1 - 1.6e-40 137.3 3.1 2e-40 137.0 3.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L34e Cytochrome_C7 PF14522.6 CCF53015.1 - 0.046 13.7 0.1 0.063 13.3 0.1 1.3 1 0 0 1 1 1 0 Cytochrome c7 and related cytochrome c AOX PF01786.17 CCF53016.1 - 2.6e-101 337.7 0.1 3.1e-101 337.4 0.1 1.1 1 0 0 1 1 1 1 Alternative oxidase NDT80_PhoG PF05224.12 CCF53017.1 - 3.1e-19 69.9 0.0 8.9e-19 68.4 0.0 1.8 1 0 0 1 1 1 1 NDT80 / PhoG like DNA-binding family TMEM174 PF15029.6 CCF53017.1 - 0.15 11.8 0.0 0.15 11.8 0.0 1.9 2 0 0 2 2 2 0 Transmembrane protein 174 CENP-B_dimeris PF09026.10 CCF53017.1 - 0.21 12.0 7.6 0.56 10.6 7.6 1.7 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DNA_pol_phi PF04931.13 CCF53017.1 - 3.7 5.5 8.0 5.1 5.1 8.0 1.1 1 0 0 1 1 1 0 DNA polymerase phi NDK PF00334.19 CCF53018.1 - 2.4e-55 186.2 0.0 3e-55 185.9 0.0 1.0 1 0 0 1 1 1 1 Nucleoside diphosphate kinase WD40 PF00400.32 CCF53019.1 - 1.6e-24 85.7 16.8 1.3e-05 25.8 0.6 7.6 7 1 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF53019.1 - 1.9e-16 60.1 0.1 0.00042 20.6 0.0 6.5 2 2 5 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain Transket_pyr PF02779.24 CCF53020.1 - 1.4e-32 112.8 0.1 2.8e-32 111.8 0.1 1.5 2 0 0 2 2 2 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 CCF53020.1 - 4.2e-27 94.5 0.0 1.2e-26 93.1 0.0 1.7 1 1 0 1 1 1 1 Transketolase, C-terminal domain Aldo_ket_red PF00248.21 CCF53021.1 - 2.6e-49 168.0 0.0 3.1e-48 164.5 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family Ribosomal_L10 PF00466.20 CCF53021.1 - 4.8e-05 23.4 0.0 0.0001 22.4 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein L10 DUF3089 PF11288.8 CCF53022.1 - 0.0031 17.1 0.6 0.0054 16.3 0.6 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3089) SEN1_N PF12726.7 CCF53023.1 - 1.5e-158 529.3 11.2 2.2e-158 528.8 11.2 1.2 1 0 0 1 1 1 1 SEN1 N terminal AAA_11 PF13086.6 CCF53023.1 - 7.6e-68 229.1 0.4 7.6e-68 229.1 0.4 4.3 5 0 0 5 5 5 1 AAA domain AAA_12 PF13087.6 CCF53023.1 - 2.2e-61 206.9 0.0 5.9e-61 205.6 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 CCF53023.1 - 1.3e-08 35.3 0.1 1e-07 32.4 0.0 2.6 2 1 0 2 2 2 1 AAA domain Viral_helicase1 PF01443.18 CCF53023.1 - 1.8e-05 24.6 0.5 0.48 10.1 0.0 3.4 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase IMUP PF15761.5 CCF53023.1 - 0.0015 19.2 5.5 0.0015 19.2 5.5 5.0 3 1 0 3 3 2 1 Immortalisation up-regulated protein TFIIA PF03153.13 CCF53023.1 - 0.0029 17.7 13.8 0.0029 17.7 13.8 4.4 4 1 0 4 4 3 1 Transcription factor IIA, alpha/beta subunit UvrD_C_2 PF13538.6 CCF53023.1 - 0.019 14.8 0.0 0.048 13.5 0.0 1.7 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain AAA_22 PF13401.6 CCF53023.1 - 0.029 14.7 2.4 8.4 6.7 0.5 3.7 3 0 0 3 3 3 0 AAA domain UvrD_C PF13361.6 CCF53023.1 - 0.2 11.0 0.0 0.2 11.0 0.0 2.1 3 0 0 3 3 2 0 UvrD-like helicase C-terminal domain Activator_LAG-3 PF11498.8 CCF53023.1 - 3.3 6.6 41.4 0.14 11.1 30.9 2.3 2 0 0 2 2 2 0 Transcriptional activator LAG-3 vATP-synt_AC39 PF01992.16 CCF53024.1 - 1.3e-109 366.7 0.1 1.5e-109 366.6 0.1 1.0 1 0 0 1 1 1 1 ATP synthase (C/AC39) subunit Antimicrobial_6 PF08036.11 CCF53024.1 - 0.2 11.7 0.0 0.4 10.8 0.0 1.4 1 0 0 1 1 1 0 Diapausin family of antimicrobial peptide RVT_1 PF00078.27 CCF53025.1 - 9.9e-25 87.4 0.2 1.2e-23 83.8 0.0 2.5 3 0 0 3 3 3 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC PF00098.23 CCF53025.1 - 5.3e-05 23.1 5.1 0.00013 21.9 5.1 1.7 1 0 0 1 1 1 1 Zinc knuckle Retrotrans_gag PF03732.17 CCF53025.1 - 0.00074 19.7 0.4 0.0028 17.9 0.0 2.2 2 0 0 2 2 2 1 Retrotransposon gag protein RT_RNaseH PF17917.1 CCF53026.1 - 3.4e-22 78.7 0.1 1.4e-21 76.7 0.0 2.1 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 CCF53026.1 - 1.4e-18 67.2 0.0 1.2e-17 64.2 0.0 2.4 2 0 0 2 2 2 1 Integrase core domain RT_RNaseH_2 PF17919.1 CCF53026.1 - 1.8e-16 60.0 0.0 3.6e-08 33.4 0.0 3.0 3 0 0 3 3 3 2 RNase H-like domain found in reverse transcriptase rve_3 PF13683.6 CCF53026.1 - 6.2e-07 29.1 0.0 2.5e-06 27.1 0.0 2.1 1 0 0 1 1 1 1 Integrase core domain zf-CCHC PF00098.23 CCF53026.1 - 1.1e-05 25.2 1.1 2.9e-05 23.9 1.1 1.8 1 0 0 1 1 1 1 Zinc knuckle Integrase_H2C2 PF17921.1 CCF53026.1 - 4e-05 23.6 0.2 0.00016 21.7 0.1 2.2 2 0 0 2 2 2 1 Integrase zinc binding domain DDE_3 PF13358.6 CCF53026.1 - 0.0005 19.9 0.0 0.0011 18.7 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease Aminotran_4 PF01063.19 CCF53027.1 - 1.6e-18 67.4 0.0 2.3e-18 66.9 0.0 1.1 1 0 0 1 1 1 1 Amino-transferase class IV CPSF_A PF03178.15 CCF53029.1 - 1.6e-42 145.9 0.0 4.4e-42 144.5 0.0 1.8 1 0 0 1 1 1 1 CPSF A subunit region MMS1_N PF10433.9 CCF53029.1 - 1.6e-41 142.5 0.0 4.3e-41 141.1 0.0 1.8 1 1 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term AA_permease_2 PF13520.6 CCF53030.1 - 1.3e-47 162.6 40.7 1.3e-47 162.6 40.7 1.3 1 1 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 CCF53030.1 - 1.2e-18 67.0 44.4 2.4e-18 66.0 44.4 1.5 1 1 0 1 1 1 1 Amino acid permease PALP PF00291.25 CCF53031.1 - 4.3e-56 190.5 0.0 1.8e-38 132.7 0.0 2.1 2 0 0 2 2 2 2 Pyridoxal-phosphate dependent enzyme RSN1_7TM PF02714.15 CCF53032.1 - 2.5e-33 115.6 26.9 3.9e-33 115.0 26.9 1.3 1 0 0 1 1 1 1 Calcium-dependent channel, 7TM region, putative phosphate PHM7_cyt PF14703.6 CCF53032.1 - 2.5e-15 57.2 7.9 2.1e-11 44.4 0.6 4.1 3 1 0 3 3 3 2 Cytosolic domain of 10TM putative phosphate transporter RSN1_TM PF13967.6 CCF53032.1 - 4.5e-15 55.7 0.9 4.5e-15 55.7 0.9 2.8 4 0 0 4 4 4 1 Late exocytosis, associated with Golgi transport Med3 PF11593.8 CCF53032.1 - 0.1 11.8 10.7 0.0073 15.5 3.9 2.2 2 0 0 2 2 2 0 Mediator complex subunit 3 fungal CAF20 PF17052.5 CCF53032.1 - 2 8.5 10.1 0.49 10.5 1.5 3.0 1 1 1 2 2 2 0 Cap associated factor ABC2_membrane PF01061.24 CCF53033.1 - 1.1e-70 237.3 77.2 5.9e-39 133.7 31.2 2.8 4 0 0 4 4 3 2 ABC-2 type transporter ABC_tran PF00005.27 CCF53033.1 - 1.2e-35 123.0 1.1 1.5e-18 67.7 0.0 3.0 3 0 0 3 3 3 2 ABC transporter PDR_CDR PF06422.12 CCF53033.1 - 6.9e-30 102.8 0.4 6.3e-23 80.5 0.0 3.4 2 0 0 2 2 2 2 CDR ABC transporter ABC_trans_N PF14510.6 CCF53033.1 - 1.2e-12 48.2 0.6 3.1e-12 46.9 0.6 1.7 1 0 0 1 1 1 1 ABC-transporter N-terminal SMC_N PF02463.19 CCF53033.1 - 3e-05 23.6 0.0 0.0001 21.8 0.0 1.9 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 CCF53033.1 - 6.4e-05 22.9 0.0 0.085 12.6 0.0 2.4 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system MMR_HSR1 PF01926.23 CCF53033.1 - 0.00018 21.6 0.1 0.077 13.1 0.0 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CCF53033.1 - 0.00021 21.3 0.2 0.00053 19.9 0.0 1.7 2 0 0 2 2 2 1 RsgA GTPase AAA_29 PF13555.6 CCF53033.1 - 0.0004 20.1 0.4 0.0095 15.7 0.2 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_18 PF13238.6 CCF53033.1 - 0.0054 17.3 0.0 0.13 12.8 0.0 2.7 3 0 0 3 3 2 1 AAA domain AAA_16 PF13191.6 CCF53033.1 - 0.0059 17.0 0.3 0.13 12.7 0.0 2.9 3 0 0 3 3 3 1 AAA ATPase domain AAA_24 PF13479.6 CCF53033.1 - 0.009 15.8 0.4 3.8 7.2 0.0 3.2 3 0 0 3 3 3 1 AAA domain AAA_22 PF13401.6 CCF53033.1 - 0.021 15.1 0.1 0.44 10.8 0.0 2.9 3 0 0 3 3 3 0 AAA domain AAA_25 PF13481.6 CCF53033.1 - 0.042 13.4 0.1 0.34 10.4 0.1 2.2 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 CCF53033.1 - 0.043 14.0 0.9 2.4 8.3 0.0 3.2 3 0 0 3 3 3 0 AAA domain cobW PF02492.19 CCF53033.1 - 0.049 13.2 0.0 0.14 11.7 0.0 1.8 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain ABC2_membrane_3 PF12698.7 CCF53033.1 - 1.8 7.6 63.6 0.74 8.9 23.5 3.8 2 1 0 2 2 2 0 ABC-2 family transporter protein DUF1764 PF08576.10 CCF53036.1 - 3.3e-17 63.2 14.7 2.8e-13 50.6 14.7 2.7 1 1 0 1 1 1 1 Eukaryotic protein of unknown function (DUF1764) MCM3AP_GANP PF16769.5 CCF53036.1 - 0.11 10.7 1.2 0.14 10.4 1.2 1.0 1 0 0 1 1 1 0 MCM3AP domain of GANP SRP-alpha_N PF04086.13 CCF53036.1 - 1.4 8.8 9.2 1.7 8.5 9.2 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal RR_TM4-6 PF06459.12 CCF53036.1 - 1.5 8.6 5.1 1.8 8.3 5.1 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Presenilin PF01080.17 CCF53036.1 - 1.7 7.3 2.7 1.8 7.2 2.7 1.1 1 0 0 1 1 1 0 Presenilin VCX_VCY PF15231.6 CCF53036.1 - 2.2 9.0 14.3 1.1 9.9 9.6 2.1 2 0 0 2 2 2 0 Variable charge X/Y family PS_Dcarbxylase PF02666.15 CCF53037.1 - 4e-52 176.7 0.0 6.1e-52 176.1 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase C2 PF00168.30 CCF53037.1 - 6.9e-36 122.7 0.0 1.9e-16 60.2 0.0 3.9 4 0 0 4 4 4 3 C2 domain SDA1 PF05285.12 CCF53037.1 - 0.019 14.4 10.0 0.03 13.8 10.0 1.2 1 0 0 1 1 1 0 SDA1 PPP4R2 PF09184.11 CCF53037.1 - 0.046 13.3 9.2 0.091 12.3 9.2 1.4 1 0 0 1 1 1 0 PPP4R2 Nop14 PF04147.12 CCF53037.1 - 0.23 9.7 17.6 0.34 9.1 17.6 1.1 1 0 0 1 1 1 0 Nop14-like family eIF-3c_N PF05470.12 CCF53037.1 - 2.7 6.2 5.8 3.9 5.7 5.8 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus Rhabdo_ncap PF00945.18 CCF53037.1 - 4.8 5.9 6.2 7.5 5.3 6.2 1.2 1 0 0 1 1 1 0 Rhabdovirus nucleocapsid protein B12D PF06522.11 CCF53038.1 - 3.6e-23 81.2 0.1 4.5e-23 80.8 0.1 1.2 1 0 0 1 1 1 1 NADH-ubiquinone reductase complex 1 MLRQ subunit ELFV_dehydrog PF00208.21 CCF53039.1 - 1.8e-25 90.1 1.0 5.2e-25 88.6 0.4 1.8 1 1 1 2 2 2 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Fe_hyd_lg_C PF02906.14 CCF53040.1 - 8.9e-52 176.2 0.0 2.8e-51 174.5 0.0 1.9 1 1 0 1 1 1 1 Iron only hydrogenase large subunit, C-terminal domain Microcin PF03526.13 CCF53040.1 - 0.12 12.2 0.4 0.25 11.2 0.4 1.5 1 0 0 1 1 1 0 Colicin E1 (microcin) immunity protein Prok_Ub PF14454.6 CCF53040.1 - 0.14 11.9 0.0 0.41 10.3 0.0 1.8 1 0 0 1 1 1 0 Prokaryotic Ubiquitin Ribosomal_60s PF00428.19 CCF53040.1 - 8.1 7.1 15.2 3.7 8.2 3.4 3.6 3 0 0 3 3 3 0 60s Acidic ribosomal protein Glyco_trans_2_3 PF13632.6 CCF53041.1 - 1.7e-15 57.5 4.4 1.7e-15 57.5 4.4 1.8 2 1 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 CCF53041.1 - 8.6e-14 52.0 0.0 1.3e-13 51.4 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 CCF53041.1 - 1e-07 31.9 0.0 1.9e-07 31.1 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_transf_21 PF13506.6 CCF53041.1 - 2.3e-05 23.9 0.0 5.2e-05 22.8 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferase family 21 DUF2206 PF09971.9 CCF53041.1 - 0.0014 17.5 0.3 0.0014 17.5 0.3 1.6 2 0 0 2 2 2 1 Predicted membrane protein (DUF2206) CoA_binding PF02629.19 CCF53042.1 - 1.2e-21 77.2 0.8 2.2e-21 76.4 0.8 1.4 1 0 0 1 1 1 1 CoA binding domain Ligase_CoA PF00549.19 CCF53042.1 - 5.6e-12 45.7 0.0 1.6e-11 44.3 0.0 1.8 1 0 0 1 1 1 1 CoA-ligase Succ_CoA_lig PF13607.6 CCF53042.1 - 0.00083 19.2 0.0 0.002 17.9 0.0 1.6 1 0 0 1 1 1 1 Succinyl-CoA ligase like flavodoxin domain GFO_IDH_MocA PF01408.22 CCF53042.1 - 0.0057 17.5 0.1 0.013 16.4 0.1 1.6 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold Ligase_CoA PF00549.19 CCF53043.1 - 1.8e-12 47.3 0.7 2.8e-12 46.7 0.7 1.2 1 0 0 1 1 1 1 CoA-ligase Ribosomal_S11 PF00411.19 CCF53043.1 - 0.031 14.7 0.1 0.071 13.5 0.1 1.6 1 0 0 1 1 1 0 Ribosomal protein S11 NAD_binding_10 PF13460.6 CCF53043.1 - 0.097 12.5 0.4 0.16 11.8 0.4 1.3 1 0 0 1 1 1 0 NAD(P)H-binding Peptidase_C12 PF01088.21 CCF53044.1 - 7.8e-53 179.3 0.0 9.3e-53 179.1 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 Med10 PF09748.9 CCF53045.1 - 1.1e-27 96.4 0.1 1.4e-27 96.0 0.1 1.1 1 0 0 1 1 1 1 Transcription factor subunit Med10 of Mediator complex DUF2236 PF09995.9 CCF53046.1 - 8.7e-13 49.0 0.0 1.5e-12 48.2 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2236) zf-C3H2C3 PF17122.5 CCF53046.1 - 0.044 13.8 1.9 0.93 9.6 0.1 2.5 2 0 0 2 2 2 0 Zinc-finger CBFD_NFYB_HMF PF00808.23 CCF53047.1 - 4.2e-19 68.6 0.5 6e-19 68.1 0.5 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 CCF53047.1 - 3.5e-13 50.0 2.8 4.7e-13 49.6 0.1 2.3 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 tRNA-synt_2 PF00152.20 CCF53048.1 - 2.3e-73 247.0 0.0 4.3e-73 246.1 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) DUF2156 PF09924.9 CCF53048.1 - 2.9e-17 62.6 0.1 4.7e-17 62.0 0.1 1.3 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2156) tRNA_anti-codon PF01336.25 CCF53048.1 - 4.1e-07 29.9 0.1 1.1e-06 28.6 0.1 1.8 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 CCF53048.1 - 0.039 13.4 0.1 10 5.5 0.0 2.6 3 0 0 3 3 3 0 tRNA synthetases class II core domain (F) His_Phos_1 PF00300.22 CCF53049.1 - 1.2e-12 47.9 0.2 1.8e-05 24.5 0.0 2.4 2 1 0 2 2 2 2 Histidine phosphatase superfamily (branch 1) ADH_zinc_N PF00107.26 CCF53050.1 - 1.5e-23 83.2 0.0 2.5e-23 82.5 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N_2 PF16884.5 CCF53050.1 - 1.4e-13 50.7 0.0 7.8e-13 48.3 0.0 2.1 2 0 0 2 2 2 1 N-terminal domain of oxidoreductase ADH_zinc_N_2 PF13602.6 CCF53050.1 - 4.8e-09 37.4 0.0 8.5e-09 36.6 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ELFV_dehydrog PF00208.21 CCF53050.1 - 0.0054 16.5 0.3 0.0074 16.0 0.3 1.2 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase MccV PF17508.2 CCF53050.1 - 0.099 13.2 1.3 0.49 11.0 0.2 2.4 2 0 0 2 2 2 0 Microcin V bacteriocin Ysc84 PF04366.12 CCF53051.1 - 5e-33 113.6 0.0 8.6e-33 112.8 0.0 1.4 1 0 0 1 1 1 1 Las17-binding protein actin regulator HAD PF12710.7 CCF53051.1 - 0.0027 18.2 0.1 1.6 9.1 0.1 2.7 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase RskA PF10099.9 CCF53053.1 - 0.00094 19.5 0.5 0.0012 19.1 0.5 1.2 1 0 0 1 1 1 1 Anti-sigma-K factor rskA ECH_1 PF00378.20 CCF53054.1 - 1.6e-37 129.2 0.0 2.7e-37 128.4 0.0 1.3 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 CCF53054.1 - 1.9e-17 63.8 0.0 8e-17 61.7 0.0 1.7 1 1 1 2 2 2 1 Enoyl-CoA hydratase/isomerase PWI PF01480.17 CCF53055.1 - 5e-29 100.4 0.1 8.3e-29 99.7 0.1 1.3 1 0 0 1 1 1 1 PWI domain Methyltransf_31 PF13847.6 CCF53056.1 - 0.0005 19.9 0.0 0.0022 17.8 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain BUD22 PF09073.10 CCF53057.1 - 0.013 14.9 21.7 0.018 14.4 21.7 1.2 1 0 0 1 1 1 0 BUD22 Borrelia_P83 PF05262.11 CCF53057.1 - 0.078 11.5 11.0 0.094 11.2 11.0 1.2 1 0 0 1 1 1 0 Borrelia P83/100 protein DUF1682 PF07946.14 CCF53057.1 - 0.14 11.4 13.9 0.19 10.9 13.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) Coilin_N PF15862.5 CCF53057.1 - 0.24 11.2 6.0 0.47 10.3 6.0 1.6 1 0 0 1 1 1 0 Coilin N-terminus DUF3807 PF12720.7 CCF53057.1 - 0.43 10.8 14.6 1.2 9.4 14.6 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) NARP1 PF12569.8 CCF53057.1 - 1.2 8.0 15.0 1.8 7.4 15.0 1.2 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 SLC12 PF03522.15 CCF53057.1 - 1.2 8.1 4.9 1.8 7.5 4.9 1.2 1 0 0 1 1 1 0 Solute carrier family 12 SURF2 PF05477.11 CCF53057.1 - 2.3 7.9 13.3 4.5 6.9 13.3 1.5 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) RR_TM4-6 PF06459.12 CCF53057.1 - 2.8 7.7 16.7 0.1 12.4 8.8 2.1 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 Tim54 PF11711.8 CCF53057.1 - 4.4 6.0 10.2 8.7 5.0 10.2 1.4 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 PPL5 PF18168.1 CCF53057.1 - 5.1 6.3 9.0 11 5.2 9.0 1.5 1 0 0 1 1 1 0 Prim-pol family 5 Paf1 PF03985.13 CCF53057.1 - 6.8 5.6 17.5 10 5.0 17.5 1.2 1 0 0 1 1 1 0 Paf1 Hid1 PF12722.7 CCF53057.1 - 7.5 4.5 6.9 10 4.1 6.9 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein PRP1_N PF06424.12 CCF53058.1 - 0.056 13.8 0.1 0.079 13.3 0.1 1.2 1 0 0 1 1 1 0 PRP1 splicing factor, N-terminal DUF2087 PF09860.9 CCF53058.1 - 0.19 11.9 0.0 0.26 11.4 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2087) dCMP_cyt_deam_1 PF00383.23 CCF53059.1 - 2.4e-14 53.0 0.2 4.9e-14 52.0 0.1 1.6 1 1 1 2 2 2 1 Cytidine and deoxycytidylate deaminase zinc-binding region dCMP_cyt_deam_2 PF08211.12 CCF53059.1 - 6.8e-12 45.7 1.0 8e-09 35.8 0.1 2.2 2 0 0 2 2 2 2 Cytidine and deoxycytidylate deaminase zinc-binding region LmjF365940-deam PF14421.6 CCF53059.1 - 0.0012 18.5 1.0 0.013 15.1 0.0 2.3 1 1 1 2 2 2 1 A distinct subfamily of CDD/CDA-like deaminases NTP_transf_9 PF04248.12 CCF53061.1 - 6.7e-19 67.6 0.1 1.4e-18 66.6 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF427) MFS_1 PF07690.16 CCF53061.1 - 7.1e-17 61.4 26.8 4.4e-11 42.3 15.4 2.7 2 1 0 2 2 2 2 Major Facilitator Superfamily ATG22 PF11700.8 CCF53061.1 - 0.00025 19.8 4.8 0.00025 19.8 4.8 2.4 3 0 0 3 3 3 2 Vacuole effluxer Atg22 like Na_H_Exchanger PF00999.21 CCF53062.1 - 5.9e-56 189.9 17.2 7.7e-56 189.5 17.2 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family YrhC PF14143.6 CCF53062.1 - 0.00037 20.5 0.6 0.0038 17.3 0.0 2.8 3 0 0 3 3 3 1 YrhC-like protein FGGY_C PF02782.16 CCF53063.1 - 2.7e-16 59.9 0.0 5.7e-16 58.8 0.0 1.6 1 1 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.21 CCF53063.1 - 2.8e-09 36.9 0.0 4.5e-06 26.4 0.0 3.0 2 1 1 3 3 3 2 FGGY family of carbohydrate kinases, N-terminal domain NMO PF03060.15 CCF53064.1 - 4.5e-35 121.6 0.9 1.4e-25 90.4 0.0 2.2 2 0 0 2 2 2 2 Nitronate monooxygenase CoA_transf_3 PF02515.17 CCF53065.1 - 4.4e-126 420.9 0.0 5.3e-126 420.7 0.0 1.1 1 0 0 1 1 1 1 CoA-transferase family III DUF2034 PF10356.9 CCF53065.1 - 0.22 11.0 0.0 0.36 10.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2034) Got1 PF04178.12 CCF53066.1 - 3.8e-25 88.5 23.6 5.2e-25 88.1 23.6 1.2 1 0 0 1 1 1 1 Got1/Sft2-like family DUF3021 PF11457.8 CCF53066.1 - 0.15 12.4 20.2 0.24 11.8 20.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3021) EcsB PF05975.12 CCF53066.1 - 0.16 10.8 16.6 0.21 10.4 16.6 1.1 1 0 0 1 1 1 0 Bacterial ABC transporter protein EcsB DUF3040 PF11239.8 CCF53066.1 - 3.7 7.9 15.2 0.12 12.7 2.7 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3040) Stevor PF17410.2 CCF53066.1 - 6.2 6.3 5.1 7.5 6.0 5.1 1.1 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame Zn_clus PF00172.18 CCF53067.1 - 0.00024 21.2 11.3 0.00046 20.2 11.3 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Activator_LAG-3 PF11498.8 CCF53067.1 - 0.00027 20.0 10.1 0.00027 20.0 10.1 2.4 3 0 0 3 3 3 1 Transcriptional activator LAG-3 Borrelia_P83 PF05262.11 CCF53067.1 - 0.00075 18.1 4.0 0.0011 17.6 4.0 1.2 1 0 0 1 1 1 1 Borrelia P83/100 protein PAS PF00989.25 CCF53067.1 - 0.0045 17.0 0.6 0.012 15.6 0.0 2.0 2 0 0 2 2 2 1 PAS fold DUF4407 PF14362.6 CCF53067.1 - 0.13 11.6 9.5 0.049 13.0 5.9 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) EPL1 PF10513.9 CCF53067.1 - 3.2 8.1 16.7 0.26 11.7 6.5 3.0 3 0 0 3 3 3 0 Enhancer of polycomb-like Cpta_toxin PF07254.12 CCF53068.1 - 0.22 11.5 3.1 0.18 11.8 0.5 2.1 2 1 0 3 3 3 0 Membrane-bound toxin component of toxin-antitoxin system Allantoicase PF03561.15 CCF53069.1 - 4.7e-87 289.3 0.0 4.7e-43 146.6 0.0 2.2 2 0 0 2 2 2 2 Allantoicase repeat Ureidogly_lyase PF04115.12 CCF53069.1 - 1.1e-52 178.5 0.1 1.8e-52 177.9 0.1 1.3 1 0 0 1 1 1 1 Ureidoglycolate lyase PAF-AH_p_II PF03403.13 CCF53070.1 - 3.5e-47 160.7 0.0 1.1e-44 152.5 0.0 2.2 2 0 0 2 2 2 2 Platelet-activating factor acetylhydrolase, isoform II Hydrolase_4 PF12146.8 CCF53070.1 - 0.00081 18.7 0.0 0.52 9.5 0.1 2.3 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 CCF53070.1 - 0.017 15.7 3.9 0.09 13.4 1.9 2.6 1 1 1 2 2 2 0 Alpha/beta hydrolase family Chlorophyllase2 PF12740.7 CCF53070.1 - 0.022 13.7 0.0 0.25 10.2 0.0 2.1 2 0 0 2 2 2 0 Chlorophyllase enzyme Esterase PF00756.20 CCF53070.1 - 0.063 12.9 0.0 0.16 11.6 0.0 1.7 1 0 0 1 1 1 0 Putative esterase HAD_2 PF13419.6 CCF53070.1 - 0.12 12.4 0.0 0.28 11.2 0.0 1.6 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase SNARE PF05739.19 CCF53074.1 - 0.026 14.5 0.0 0.038 14.0 0.0 1.3 1 0 0 1 1 1 0 SNARE domain MIP PF00230.20 CCF53076.1 - 1.6e-43 149.0 3.8 2.2e-43 148.6 3.8 1.2 1 0 0 1 1 1 1 Major intrinsic protein 2TM PF13239.6 CCF53076.1 - 0.87 9.9 0.0 0.87 9.9 0.0 3.4 2 1 1 3 3 3 0 2TM domain DNA_pol_B PF00136.21 CCF53077.1 - 2.3e-98 329.9 0.0 3.1e-98 329.5 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 CCF53077.1 - 1.2e-24 87.1 0.0 4.2e-12 45.9 0.0 2.3 2 0 0 2 2 2 2 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.6 CCF53077.1 - 2.8e-12 46.9 7.2 5.6e-12 46.0 7.2 1.5 1 0 0 1 1 1 1 C4-type zinc-finger of DNA polymerase delta MutL_C PF08676.11 CCF53078.1 - 1.1e-22 80.4 0.0 3e-22 79.0 0.0 1.7 1 0 0 1 1 1 1 MutL C terminal dimerisation domain DNA_mis_repair PF01119.19 CCF53078.1 - 8.2e-20 70.7 0.0 1.8e-19 69.5 0.0 1.6 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.6 CCF53078.1 - 1.6e-11 44.1 0.0 4.3e-11 42.8 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 CCF53078.1 - 3.1e-06 27.7 0.1 1.2e-05 25.8 0.0 2.0 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Takusan PF04822.13 CCF53079.1 - 0.0097 15.8 1.7 0.35 10.8 0.1 2.2 2 0 0 2 2 2 2 Takusan DUF4140 PF13600.6 CCF53079.1 - 0.12 12.8 1.5 13 6.2 0.3 2.1 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) DUF3585 PF12130.8 CCF53079.1 - 0.51 10.5 5.7 1.1 9.3 5.7 1.5 1 1 0 1 1 1 0 Bivalent Mical/EHBP Rab binding domain ERG2_Sigma1R PF04622.12 CCF53080.1 - 8e-90 299.8 0.0 9.7e-90 299.5 0.0 1.0 1 0 0 1 1 1 1 ERG2 and Sigma1 receptor like protein Rhodanese PF00581.20 CCF53081.1 - 1.6e-06 28.6 0.0 3e-06 27.7 0.0 1.5 1 1 0 1 1 1 1 Rhodanese-like domain ECH_1 PF00378.20 CCF53082.1 - 2.9e-50 170.9 0.0 3.6e-50 170.6 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 CCF53082.1 - 2.6e-25 89.6 0.1 1.9e-22 80.3 0.1 2.1 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase AMP-binding PF00501.28 CCF53083.1 - 5.3e-78 262.5 0.1 5.4e-51 173.5 0.0 2.1 2 0 0 2 2 2 2 AMP-binding enzyme AMP-binding_C PF13193.6 CCF53083.1 - 1e-11 45.6 0.0 6.6e-11 43.0 0.0 2.4 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain Metallophos PF00149.28 CCF53084.1 - 9.5e-12 45.8 2.4 1.8e-11 44.9 2.4 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Abhydrolase_6 PF12697.7 CCF53085.1 - 3e-09 37.8 0.8 3e-09 37.8 0.8 2.0 2 0 0 2 2 2 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CCF53085.1 - 0.0018 17.6 0.0 0.0031 16.8 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 MIX PF18529.1 CCF53085.1 - 0.37 10.5 1.6 0.64 9.7 0.3 2.0 2 0 0 2 2 2 0 Mitochondrial membrane-anchored proteins CUE PF02845.16 CCF53086.1 - 4.1e-11 42.4 0.0 6.7e-11 41.7 0.0 1.4 1 0 0 1 1 1 1 CUE domain G2BR PF18442.1 CCF53086.1 - 0.014 15.0 6.2 0.028 14.1 6.2 1.4 1 0 0 1 1 1 0 E3 gp78 Ube2g2-binding region (G2BR) DUF4834 PF16118.5 CCF53086.1 - 0.17 12.8 0.9 5.9 7.9 0.9 2.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4834) Ribosomal_L37 PF08561.10 CCF53087.1 - 2e-31 109.0 7.9 2.8e-31 108.5 7.9 1.2 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L37 Peptidase_M19 PF01244.21 CCF53089.1 - 1.9e-87 293.5 0.0 2.2e-87 293.2 0.0 1.0 1 0 0 1 1 1 1 Membrane dipeptidase (Peptidase family M19) Glyco_hydro_31 PF01055.26 CCF53090.1 - 4.8e-79 266.6 0.0 6.5e-79 266.2 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.6 CCF53090.1 - 2.3e-09 37.4 0.0 7.7e-09 35.7 0.0 2.0 1 0 0 1 1 1 1 Galactose mutarotase-like DUF5110 PF17137.4 CCF53090.1 - 0.062 13.6 0.0 0.41 10.9 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF5110) MFS_1 PF07690.16 CCF53091.1 - 5.2e-35 121.0 21.1 7.1e-35 120.6 21.1 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Glyco_hydro_32N PF00251.20 CCF53092.1 - 5.6e-86 288.9 5.5 7.8e-86 288.4 5.5 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 32 N-terminal domain Glyco_hydro_32C PF08244.12 CCF53092.1 - 5.6e-11 42.7 0.4 2.8e-10 40.4 0.1 2.3 3 0 0 3 3 3 1 Glycosyl hydrolases family 32 C terminal PXA PF02194.15 CCF53094.1 - 1.2e-44 152.4 0.4 1.2e-44 152.4 0.4 2.6 2 1 0 2 2 2 1 PXA domain Nexin_C PF08628.12 CCF53094.1 - 2.7e-05 24.7 0.1 0.00019 22.0 0.0 2.4 3 0 0 3 3 3 1 Sorting nexin C terminal DUF4834 PF16118.5 CCF53094.1 - 1.1 10.3 3.4 3.3 8.7 0.0 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) peroxidase PF00141.23 CCF53096.1 - 1.2e-47 162.5 0.0 1.8e-47 162.0 0.0 1.2 1 0 0 1 1 1 1 Peroxidase MGTL PF17059.5 CCF53098.1 - 0.29 11.0 5.1 0.18 11.6 2.4 2.0 2 0 0 2 2 2 0 MgtA leader peptide CD20 PF04103.15 CCF53098.1 - 8.5 6.4 8.5 0.41 10.7 1.3 2.4 3 0 0 3 3 3 0 CD20-like family Glyco_hydro_88 PF07470.13 CCF53099.1 - 5.7e-82 275.6 1.9 7.5e-82 275.2 1.9 1.1 1 0 0 1 1 1 1 Glycosyl Hydrolase Family 88 Acetyltransf_3 PF13302.7 CCF53100.1 - 6.9e-14 52.7 0.0 1.3e-13 51.8 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CCF53100.1 - 0.00068 19.9 0.0 0.001 19.3 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_4 PF13420.7 CCF53100.1 - 0.017 15.3 0.7 0.024 14.7 0.1 1.5 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain UvdE PF03851.14 CCF53101.1 - 2.9e-85 285.9 0.0 3.9e-85 285.4 0.0 1.2 1 0 0 1 1 1 1 UV-endonuclease UvdE RCC1 PF00415.18 CCF53102.1 - 1.7e-24 86.2 12.5 1.1e-13 51.6 0.0 8.5 9 0 0 9 9 9 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 CCF53102.1 - 1.5e-13 50.1 7.0 1.5e-08 34.2 0.2 6.4 7 0 0 7 7 7 3 Regulator of chromosome condensation (RCC1) repeat N6-adenineMlase PF10237.9 CCF53103.1 - 1.5e-31 109.4 0.1 4.8e-31 107.7 0.1 1.8 1 1 0 1 1 1 1 Probable N6-adenine methyltransferase BORCS6 PF10157.9 CCF53103.1 - 0.0095 16.2 2.5 0.018 15.3 2.5 1.4 1 0 0 1 1 1 1 BLOC-1-related complex sub-unit 6 Mem_trans PF03547.18 CCF53103.1 - 0.15 10.4 0.1 0.14 10.5 0.1 1.1 1 0 0 1 1 1 0 Membrane transport protein 4HBT PF03061.22 CCF53104.1 - 1.2e-12 48.0 0.0 2.2e-12 47.2 0.0 1.4 1 0 0 1 1 1 1 Thioesterase superfamily 4HBT_3 PF13622.6 CCF53104.1 - 0.0066 16.7 0.3 0.013 15.8 0.0 1.6 2 0 0 2 2 2 1 Thioesterase-like superfamily PRELI PF04707.14 CCF53105.1 - 3e-38 131.1 0.0 3.6e-38 130.8 0.0 1.0 1 0 0 1 1 1 1 PRELI-like family DUF3530 PF12048.8 CCF53105.1 - 0.2 11.0 0.0 0.26 10.7 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3530) Glyco_hydro_47 PF01532.20 CCF53106.1 - 1.5e-129 432.9 0.0 1.7e-129 432.7 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Glyco_hydro_76 PF03663.14 CCF53106.1 - 0.0001 21.9 0.5 0.16 11.4 0.0 3.0 2 1 1 3 3 3 2 Glycosyl hydrolase family 76 PIRT PF15099.6 CCF53108.1 - 2.2 7.8 5.0 1.7 8.3 0.0 2.6 3 0 0 3 3 3 0 Phosphoinositide-interacting protein family WES_acyltransf PF03007.16 CCF53109.1 - 1.6e-12 47.8 2.2 1.6e-12 47.7 0.0 2.1 2 1 1 3 3 3 1 Wax ester synthase-like Acyl-CoA acyltransferase domain DUF1298 PF06974.13 CCF53109.1 - 1.7e-09 37.8 0.0 3.2e-09 36.9 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1298) DSBA PF01323.20 CCF53110.1 - 1.2e-12 48.1 0.6 1.1e-10 41.6 0.6 2.7 1 1 0 1 1 1 1 DSBA-like thioredoxin domain PTH2 PF01981.16 CCF53110.1 - 0.084 13.2 0.0 0.27 11.5 0.0 1.8 1 0 0 1 1 1 0 Peptidyl-tRNA hydrolase PTH2 Fungal_trans_2 PF11951.8 CCF53111.1 - 1.4e-12 47.1 0.2 1.5e-11 43.7 0.0 2.1 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF53111.1 - 1.6e-09 37.8 11.6 2.5e-09 37.1 11.6 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain RP-C_C PF11800.8 CCF53112.1 - 0.045 13.9 0.0 0.045 13.9 0.0 1.1 1 0 0 1 1 1 0 Replication protein C C-terminal region GalKase_gal_bdg PF10509.9 CCF53113.1 - 2.9e-21 74.7 0.0 1.3e-20 72.7 0.0 2.0 2 0 0 2 2 2 1 Galactokinase galactose-binding signature GHMP_kinases_N PF00288.26 CCF53113.1 - 1.6e-12 47.4 1.6 2.8e-12 46.7 0.3 2.0 2 0 0 2 2 2 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 CCF53113.1 - 4.9e-11 42.8 0.0 1.5e-10 41.3 0.0 1.8 1 0 0 1 1 1 1 GHMP kinases C terminal Zn_clus PF00172.18 CCF53114.1 - 1.9e-05 24.7 11.1 3.9e-05 23.7 11.1 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 CCF53114.1 - 0.00024 20.3 0.1 0.00039 19.5 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Bacteriocin_IIc PF10439.9 CCF53114.1 - 4.5 7.5 17.0 14 5.9 9.6 3.0 3 0 0 3 3 3 0 Bacteriocin class II with double-glycine leader peptide MFS_1 PF07690.16 CCF53115.1 - 2.4e-37 128.7 50.5 3.8e-36 124.7 49.7 2.6 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF53115.1 - 3.9e-12 45.8 5.7 3.9e-12 45.8 5.7 2.5 2 0 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.13 CCF53115.1 - 0.00011 20.7 11.5 0.00016 20.2 11.5 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) FPN1 PF06963.12 CCF53116.1 - 4.9e-141 470.3 5.7 5.6e-141 470.0 5.7 1.0 1 0 0 1 1 1 1 Ferroportin1 (FPN1) UCR_Fe-S_N PF10399.9 CCF53116.1 - 0.095 12.1 1.3 0.25 10.7 1.3 1.7 1 0 0 1 1 1 0 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal ACOX PF01756.19 CCF53117.1 - 3.3e-37 127.8 0.0 1.6e-36 125.6 0.0 1.9 2 0 0 2 2 2 1 Acyl-CoA oxidase Acyl-CoA_ox_N PF14749.6 CCF53117.1 - 2.1e-19 70.3 0.2 4.5e-19 69.2 0.2 1.6 1 0 0 1 1 1 1 Acyl-coenzyme A oxidase N-terminal Acyl-CoA_dh_M PF02770.19 CCF53117.1 - 3.4e-06 27.2 0.0 6.4e-06 26.3 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_1 PF00441.24 CCF53117.1 - 0.00017 21.8 0.1 0.0004 20.6 0.1 1.7 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain TAL_effector PF03377.13 CCF53117.1 - 0.029 14.7 0.0 0.089 13.1 0.0 1.9 1 0 0 1 1 1 0 TAL effector repeat Pyr_redox_2 PF07992.14 CCF53118.1 - 6.9e-25 87.9 0.0 9.1e-25 87.5 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CCF53118.1 - 2e-06 28.3 0.3 1.3e-05 25.7 0.1 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CCF53118.1 - 1.3e-05 24.7 0.0 6.7e-05 22.3 0.0 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 CCF53118.1 - 4.6e-05 22.7 0.0 0.00019 20.7 0.0 1.8 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 CCF53118.1 - 0.0041 17.1 1.1 7.6 6.5 0.1 4.0 4 0 0 4 4 4 1 FAD-NAD(P)-binding Trp_halogenase PF04820.14 CCF53118.1 - 0.0045 15.9 1.2 0.68 8.7 0.1 2.5 3 0 0 3 3 3 2 Tryptophan halogenase Lycopene_cycl PF05834.12 CCF53118.1 - 0.076 12.1 0.8 2.9 6.8 0.1 2.4 2 1 0 2 2 2 0 Lycopene cyclase protein Arrestin_C PF02752.22 CCF53119.1 - 3.7e-20 72.7 0.0 1.3e-19 71.0 0.0 2.0 1 0 0 1 1 1 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 CCF53119.1 - 5.1e-08 33.1 0.0 7.9e-06 26.0 0.0 2.5 2 0 0 2 2 2 2 Arrestin (or S-antigen), N-terminal domain Sgf11 PF08209.11 CCF53120.1 - 4.6e-15 54.9 0.5 8.9e-15 54.0 0.5 1.5 1 0 0 1 1 1 1 Sgf11 (transcriptional regulation protein) RNA_pol_3_Rpc31 PF11705.8 CCF53120.1 - 0.33 11.2 18.3 0.16 12.2 2.1 2.4 2 0 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 Cwf_Cwc_15 PF04889.12 CCF53120.1 - 0.39 10.4 18.7 1.5 8.5 3.0 2.3 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein NOA36 PF06524.12 CCF53120.1 - 0.89 8.8 20.2 0.12 11.7 6.3 2.4 2 0 0 2 2 2 0 NOA36 protein zf-C2HC_2 PF13913.6 CCF53120.1 - 1.1 9.2 4.7 0.24 11.3 0.4 2.1 2 0 0 2 2 2 0 zinc-finger of a C2HC-type Serglycin PF04360.12 CCF53120.1 - 5.3 7.0 11.5 0.63 10.0 4.8 2.5 2 0 0 2 2 2 0 Serglycin AF-4 PF05110.13 CCF53121.1 - 4.7 5.2 10.8 5.3 5.0 10.8 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein SR-25 PF10500.9 CCF53121.1 - 6.2 6.4 8.8 8.2 6.0 8.8 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein GFA PF04828.14 CCF53122.1 - 4.7e-22 78.1 0.2 6.1e-22 77.8 0.2 1.2 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme DZR PF12773.7 CCF53122.1 - 0.002 18.1 1.7 0.036 14.1 0.0 2.2 2 0 0 2 2 2 1 Double zinc ribbon zf-NADH-PPase PF09297.11 CCF53122.1 - 0.043 13.5 0.5 0.043 13.5 0.5 2.4 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain Cyanate_lyase PF02560.14 CCF53123.1 - 4.4e-33 112.9 0.1 6.3e-33 112.4 0.1 1.2 1 0 0 1 1 1 1 Cyanate lyase C-terminal domain HTH_3 PF01381.22 CCF53123.1 - 0.013 15.5 0.0 0.024 14.7 0.0 1.3 1 0 0 1 1 1 0 Helix-turn-helix SNase PF00565.17 CCF53124.1 - 3e-40 137.0 0.2 9.8e-18 64.6 0.0 6.2 6 0 0 6 6 6 5 Staphylococcal nuclease homologue TUDOR PF00567.24 CCF53124.1 - 1.4e-17 63.8 0.0 3e-17 62.8 0.0 1.4 1 0 0 1 1 1 1 Tudor domain SMN PF06003.12 CCF53124.1 - 0.099 11.9 0.0 0.18 11.0 0.0 1.3 1 0 0 1 1 1 0 Survival motor neuron protein (SMN) Agenet PF05641.12 CCF53124.1 - 0.13 12.8 0.0 0.5 10.9 0.0 2.2 1 0 0 1 1 1 0 Agenet domain Zn_clus PF00172.18 CCF53125.1 - 5.3e-07 29.7 7.7 9.7e-07 28.8 7.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 CCF53125.1 - 0.14 11.1 0.0 5 6.1 0.0 2.2 2 0 0 2 2 2 0 Fungal specific transcription factor domain Macoilin PF09726.9 CCF53126.1 - 1.1 7.8 6.9 1.3 7.4 6.9 1.0 1 0 0 1 1 1 0 Macoilin family SOG2 PF10428.9 CCF53126.1 - 1.2 8.3 11.3 1.4 8.0 11.3 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein MGC-24 PF05283.11 CCF53126.1 - 2.1 8.8 9.6 3.3 8.1 9.6 1.3 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin FSA_C PF10479.9 CCF53126.1 - 3.5 5.7 11.0 4.1 5.4 11.0 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus NAD_binding_11 PF14833.6 CCF53127.1 - 3.4e-17 62.8 0.2 6e-17 62.0 0.2 1.4 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase MTS PF05175.14 CCF53129.1 - 2e-05 24.2 0.0 0.0018 17.8 0.0 2.1 2 0 0 2 2 2 2 Methyltransferase small domain Methyltransf_25 PF13649.6 CCF53129.1 - 0.0011 19.7 0.0 0.0024 18.5 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_24 PF13578.6 CCF53129.1 - 0.07 14.2 0.0 0.14 13.2 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain PrmA PF06325.13 CCF53129.1 - 0.13 11.7 0.0 0.2 11.0 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_11 PF08241.12 CCF53129.1 - 0.14 12.8 0.0 0.46 11.2 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase domain p450 PF00067.22 CCF53130.1 - 2.6e-65 221.0 0.0 1e-64 219.0 0.0 1.8 1 1 0 1 1 1 1 Cytochrome P450 DUF2499 PF10693.9 CCF53130.1 - 0.18 12.1 0.0 0.54 10.6 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2499) SCP2 PF02036.17 CCF53131.1 - 1.9e-07 31.5 0.1 2.4e-07 31.2 0.1 1.2 1 0 0 1 1 1 1 SCP-2 sterol transfer family Acyl_transf_1 PF00698.21 CCF53132.1 - 5.9e-14 52.3 1.3 7.1e-11 42.2 0.3 2.6 2 0 0 2 2 2 2 Acyl transferase domain MFS_1 PF07690.16 CCF53133.1 - 6.3e-34 117.4 61.4 1.7e-30 106.1 51.2 2.8 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF53133.1 - 7e-06 25.2 13.0 7e-06 25.2 13.0 3.1 1 1 2 3 3 3 1 Sugar (and other) transporter DUF202 PF02656.15 CCF53133.1 - 0.14 12.6 0.1 0.14 12.6 0.1 6.2 6 1 0 6 6 6 0 Domain of unknown function (DUF202) OATP PF03137.20 CCF53133.1 - 0.81 7.9 18.6 5.6 5.1 0.1 3.2 1 1 1 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family YlaH PF14036.6 CCF53133.1 - 6.3 7.2 11.8 0.22 11.9 4.2 2.5 2 0 0 2 2 2 0 YlaH-like protein ADH_N PF08240.12 CCF53134.1 - 3e-28 97.9 0.5 4.9e-28 97.2 0.5 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CCF53134.1 - 3.5e-25 88.5 0.4 5.5e-25 87.8 0.4 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CCF53134.1 - 6.4e-08 33.7 0.1 1.2e-07 32.8 0.1 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase adh_short PF00106.25 CCF53134.1 - 0.015 14.8 0.0 0.057 12.9 0.1 1.9 2 0 0 2 2 2 0 short chain dehydrogenase TPR_5 PF12688.7 CCF53135.1 - 0.056 13.7 0.0 0.12 12.6 0.0 1.5 1 0 0 1 1 1 0 Tetratrico peptide repeat Thiolase_N PF00108.23 CCF53136.1 - 9.6e-18 64.5 0.2 8.7e-16 58.1 0.0 2.5 2 1 1 3 3 3 2 Thiolase, N-terminal domain Thiolase_C PF02803.18 CCF53136.1 - 2e-08 33.9 0.3 1.1e-07 31.5 0.1 2.4 3 0 0 3 3 3 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 CCF53136.1 - 4.2e-05 23.2 3.7 0.00041 20.0 2.9 2.2 1 1 1 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III PF08545.10 CCF53136.1 - 0.0015 18.3 1.1 0.019 14.8 0.3 2.4 2 0 0 2 2 2 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III SpoVAD PF07451.11 CCF53136.1 - 0.0043 15.8 0.3 0.046 12.4 0.3 2.1 2 0 0 2 2 2 1 Stage V sporulation protein AD (SpoVAD) Ketoacyl-synt_C PF02801.22 CCF53136.1 - 0.094 12.7 0.4 0.68 10.0 0.0 2.5 3 0 0 3 3 3 0 Beta-ketoacyl synthase, C-terminal domain MFS_1 PF07690.16 CCF53138.1 - 6.8e-41 140.4 34.9 6.8e-41 140.4 34.9 1.8 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF53138.1 - 3.4e-13 49.3 9.2 3.4e-13 49.3 9.2 2.6 1 1 1 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.13 CCF53138.1 - 3.2e-12 45.7 1.3 5e-12 45.0 1.3 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_4 PF06779.14 CCF53138.1 - 7.4e-08 32.1 5.2 1.5e-07 31.0 5.2 1.4 1 0 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB F-box-like PF12937.7 CCF53139.1 - 3.8e-08 33.1 0.4 3.8e-08 33.1 0.4 2.6 3 0 0 3 3 3 1 F-box-like SpvB PF03534.13 CCF53139.1 - 0.098 11.8 0.0 0.15 11.2 0.0 1.1 1 0 0 1 1 1 0 Salmonella virulence plasmid 65kDa B protein Abhydrolase_4 PF08386.10 CCF53140.1 - 1.9e-19 69.7 0.0 3.5e-19 68.8 0.0 1.5 1 0 0 1 1 1 1 TAP-like protein Abhydrolase_1 PF00561.20 CCF53140.1 - 5e-18 65.7 0.0 1.7e-17 64.0 0.1 1.8 2 0 0 2 2 2 1 alpha/beta hydrolase fold NMO PF03060.15 CCF53141.1 - 3.5e-51 174.6 2.6 3.2e-50 171.4 2.6 1.9 1 1 0 1 1 1 1 Nitronate monooxygenase IMPDH PF00478.25 CCF53141.1 - 2.8e-10 39.7 0.9 1e-07 31.3 0.9 2.2 1 1 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain FMN_dh PF01070.18 CCF53141.1 - 0.0004 19.5 0.6 0.00068 18.8 0.6 1.4 1 0 0 1 1 1 1 FMN-dependent dehydrogenase His_biosynth PF00977.21 CCF53141.1 - 0.015 14.7 0.1 0.028 13.9 0.1 1.3 1 0 0 1 1 1 0 Histidine biosynthesis protein TMP-TENI PF02581.17 CCF53141.1 - 0.018 14.3 0.2 0.036 13.4 0.2 1.5 1 0 0 1 1 1 0 Thiamine monophosphate synthase DUF1729 PF08354.10 CCF53141.1 - 0.16 10.8 0.0 0.29 10.0 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1729) M20_dimer PF07687.14 CCF53142.1 - 3.1e-10 39.9 0.2 8.1e-10 38.6 0.0 1.7 2 0 0 2 2 2 1 Peptidase dimerisation domain Peptidase_M20 PF01546.28 CCF53142.1 - 1.2e-08 34.9 0.2 2.5e-08 33.9 0.2 1.5 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 MatE PF01554.18 CCF53143.1 - 3.6e-53 179.5 27.1 9.8e-28 96.8 9.9 2.5 2 0 0 2 2 2 2 MatE Polysacc_synt_C PF14667.6 CCF53143.1 - 1.1e-05 25.5 9.8 1.1e-05 25.5 9.8 3.8 3 2 1 4 4 4 2 Polysaccharide biosynthesis C-terminal domain RVT_2 PF07727.14 CCF53145.1 - 4.8e-30 105.0 0.0 7.5e-30 104.3 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 CCF53145.1 - 9.7e-06 25.8 0.4 0.0014 18.8 0.4 2.4 1 1 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 CCF53145.1 - 0.018 14.8 0.0 0.056 13.2 0.0 1.8 2 0 0 2 2 2 0 Integrase core domain GST_C_6 PF17171.4 CCF53146.1 - 1.4e-07 31.2 0.0 3.4e-07 29.9 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_4 PF17172.4 CCF53146.1 - 0.0018 19.0 0.1 0.011 16.5 0.0 2.3 3 0 0 3 3 3 1 Glutathione S-transferase N-terminal domain Pterin_4a PF01329.19 CCF53147.1 - 3.7e-27 94.3 0.3 4.3e-27 94.1 0.3 1.1 1 0 0 1 1 1 1 Pterin 4 alpha carbinolamine dehydratase DUF4042 PF13251.6 CCF53148.1 - 1.1e-16 61.1 11.6 1.2e-11 44.6 7.4 6.2 4 1 0 4 4 4 1 Domain of unknown function (DUF4042) HEAT PF02985.22 CCF53148.1 - 1.6e-06 27.8 20.5 0.16 12.3 0.0 7.9 9 0 0 9 9 9 3 HEAT repeat HEAT_2 PF13646.6 CCF53148.1 - 5.8e-05 23.4 15.1 0.16 12.4 0.3 6.8 6 2 0 6 6 6 3 HEAT repeats HEAT_EZ PF13513.6 CCF53148.1 - 0.016 15.7 11.5 2.4 8.8 0.1 6.3 7 0 0 7 7 7 0 HEAT-like repeat DUF3809 PF12723.7 CCF53148.1 - 0.052 13.8 0.1 0.36 11.1 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3809) Arm PF00514.23 CCF53148.1 - 0.41 10.8 3.9 1.4 9.0 0.0 3.9 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat Lin-8 PF03353.15 CCF53148.1 - 2.6 7.6 4.9 4.1 6.9 4.9 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist GFO_IDH_MocA PF01408.22 CCF53150.1 - 6.1e-20 72.2 0.1 9.2e-20 71.7 0.1 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold Semialdhyde_dh PF01118.24 CCF53150.1 - 0.15 12.5 0.0 0.4 11.1 0.0 1.7 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain CRCB PF02537.15 CCF53151.1 - 6.8e-33 112.9 16.9 4.9e-19 68.4 5.2 2.5 2 0 0 2 2 2 2 CrcB-like protein, Camphor Resistance (CrcB) SNF2_N PF00176.23 CCF53153.1 - 3.9e-48 164.0 1.7 4.2e-48 163.8 0.3 1.9 2 0 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 CCF53153.1 - 6.9e-09 36.0 0.1 9.9e-08 32.3 0.1 2.9 3 0 0 3 3 3 1 Helicase conserved C-terminal domain zf-C3HC4_3 PF13920.6 CCF53153.1 - 7.9e-06 25.6 11.2 7.9e-06 25.6 11.2 1.7 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 CCF53153.1 - 3.9e-05 23.4 11.3 0.00021 21.1 11.7 2.0 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CCF53153.1 - 4.9e-05 23.1 13.5 0.0001 22.1 13.5 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 CCF53153.1 - 0.0014 18.4 11.2 0.003 17.4 11.2 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 CCF53153.1 - 0.002 18.0 12.9 0.002 18.0 12.9 1.8 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_2 PF13639.6 CCF53153.1 - 0.0032 17.8 14.0 0.0068 16.7 14.0 1.6 1 0 0 1 1 1 1 Ring finger domain zf-UDP PF14569.6 CCF53153.1 - 0.023 14.8 5.9 0.055 13.6 5.9 1.5 1 0 0 1 1 1 0 Zinc-binding RING-finger Zn_ribbon_17 PF17120.5 CCF53153.1 - 0.33 10.6 11.8 0.68 9.6 11.8 1.5 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-RING_UBOX PF13445.6 CCF53153.1 - 0.33 11.0 11.6 0.72 9.9 11.6 1.6 1 0 0 1 1 1 0 RING-type zinc-finger V_ATPase_I PF01496.19 CCF53153.1 - 0.57 8.0 5.2 9.6 4.0 0.0 2.3 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family zf-C3HC4_4 PF15227.6 CCF53153.1 - 1.3 9.2 10.6 2.8 8.2 10.6 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING DUF4501 PF14946.6 CCF53153.1 - 1.4 8.9 5.1 3 7.9 5.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4501) FAP206 PF12018.8 CCF53155.1 - 0.0013 18.4 0.1 0.0014 18.2 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function DAHP_synth_2 PF01474.16 CCF53157.1 - 4.8e-167 555.9 0.0 7.8e-167 555.2 0.0 1.3 1 1 0 1 1 1 1 Class-II DAHP synthetase family MFS_1 PF07690.16 CCF53158.1 - 6.7e-30 104.2 43.0 9.4e-28 97.1 22.9 1.4 1 1 1 2 2 2 2 Major Facilitator Superfamily UNC-93 PF05978.16 CCF53158.1 - 0.009 15.7 0.1 0.009 15.7 0.1 2.4 3 0 0 3 3 3 1 Ion channel regulatory protein UNC-93 DUF5360 PF17314.2 CCF53158.1 - 0.099 12.7 5.7 0.14 12.3 0.4 3.1 3 0 0 3 3 3 0 Family of unknown function (DUF5360) Ham1p_like PF01725.16 CCF53159.1 - 5e-54 183.1 0.0 5.5e-54 182.9 0.0 1.0 1 0 0 1 1 1 1 Ham1 family Trypsin_2 PF13365.6 CCF53160.1 - 0.014 16.3 0.5 0.028 15.3 0.3 1.6 1 1 0 1 1 1 0 Trypsin-like peptidase domain DUF3074 PF11274.8 CCF53162.1 - 2.1e-38 132.1 0.1 3.7e-38 131.4 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3074) PGG PF13962.6 CCF53163.1 - 0.06 13.2 0.4 0.13 12.1 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function HMGL-like PF00682.19 CCF53164.1 - 3.9e-49 167.6 0.0 4.7e-49 167.3 0.0 1.1 1 0 0 1 1 1 1 HMGL-like rve PF00665.26 CCF53166.1 - 1.1e-11 44.9 0.1 2e-11 44.1 0.1 1.5 1 0 0 1 1 1 1 Integrase core domain Hydrolase_4 PF12146.8 CCF53168.1 - 5.2e-18 65.2 0.1 1.9e-12 47.0 0.0 2.2 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 CCF53168.1 - 3.4e-12 46.6 0.1 4.6e-10 39.6 0.0 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CCF53168.1 - 1.3e-10 42.2 0.0 2.7e-10 41.2 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_3 PF07859.13 CCF53168.1 - 5.4e-08 33.0 0.0 9.1e-08 32.2 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_2 PF02230.16 CCF53168.1 - 0.0006 19.7 0.0 0.031 14.1 0.0 3.0 4 0 0 4 4 4 1 Phospholipase/Carboxylesterase DUF818 PF05677.12 CCF53168.1 - 0.0016 17.5 0.0 0.0023 16.9 0.0 1.2 1 0 0 1 1 1 1 Chlamydia CHLPS protein (DUF818) Peptidase_S9 PF00326.21 CCF53168.1 - 0.0018 17.8 0.2 0.026 14.0 0.1 2.5 1 1 1 2 2 2 1 Prolyl oligopeptidase family Thioesterase PF00975.20 CCF53168.1 - 0.041 14.0 0.0 0.056 13.5 0.0 1.3 1 1 0 1 1 1 0 Thioesterase domain BAAT_C PF08840.11 CCF53168.1 - 0.052 13.5 0.4 0.41 10.5 0.0 2.3 3 0 0 3 3 3 0 BAAT / Acyl-CoA thioester hydrolase C terminal Esterase PF00756.20 CCF53168.1 - 0.13 11.8 0.2 1.2 8.7 0.2 2.1 1 1 0 1 1 1 0 Putative esterase LRR_4 PF12799.7 CCF53169.1 - 0.00017 21.9 3.1 2.4 8.7 0.0 4.5 4 1 2 6 6 6 3 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 CCF53169.1 - 0.00073 19.4 5.4 3.6 7.9 0.0 5.8 6 0 0 6 6 6 2 Leucine Rich repeat LRR_1 PF00560.33 CCF53169.1 - 0.016 15.7 1.7 21 6.2 0.2 5.4 4 1 0 4 4 4 0 Leucine Rich Repeat F-box-like PF12937.7 CCF53169.1 - 0.094 12.6 0.0 0.2 11.6 0.0 1.6 1 0 0 1 1 1 0 F-box-like Syja_N PF02383.18 CCF53170.1 - 3.8e-93 312.3 0.0 5.1e-93 311.9 0.0 1.2 1 0 0 1 1 1 1 SacI homology domain hSac2 PF12456.8 CCF53171.1 - 1.9e-27 95.3 0.0 3.1e-27 94.6 0.0 1.3 1 0 0 1 1 1 1 Inositol phosphatase DUF667 PF05018.13 CCF53172.1 - 4.4e-18 65.7 0.1 6.5e-12 45.6 0.0 3.6 2 1 0 3 3 3 3 Protein of unknown function (DUF667) Cyt-b5 PF00173.28 CCF53173.1 - 9.8e-12 44.9 0.0 1.5e-11 44.2 0.0 1.3 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain PRK PF00485.18 CCF53174.1 - 1.9e-52 177.9 0.0 2.9e-52 177.3 0.0 1.2 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family UPRTase PF14681.6 CCF53174.1 - 8.1e-45 152.8 0.1 1.2e-42 145.7 0.0 2.2 2 0 0 2 2 2 2 Uracil phosphoribosyltransferase AAA_18 PF13238.6 CCF53174.1 - 4.8e-05 23.9 0.0 9e-05 23.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain CoaE PF01121.20 CCF53174.1 - 4.9e-05 23.1 0.0 0.00011 21.9 0.0 1.6 1 0 0 1 1 1 1 Dephospho-CoA kinase AAA_33 PF13671.6 CCF53174.1 - 0.0005 20.3 0.0 0.0015 18.7 0.0 1.8 1 0 0 1 1 1 1 AAA domain CPT PF07931.12 CCF53174.1 - 0.0021 17.9 0.0 0.0042 16.9 0.0 1.5 1 0 0 1 1 1 1 Chloramphenicol phosphotransferase-like protein Pkinase_fungal PF17667.1 CCF53174.1 - 0.13 11.0 0.0 0.22 10.3 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase AAA_28 PF13521.6 CCF53174.1 - 0.13 12.4 0.0 0.28 11.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain Methyltransf_31 PF13847.6 CCF53175.1 - 0.002 17.9 0.0 0.17 11.6 0.0 2.3 2 0 0 2 2 2 2 Methyltransferase domain Rhodanese PF00581.20 CCF53175.1 - 0.0032 18.0 0.0 0.007 16.9 0.0 1.5 1 0 0 1 1 1 1 Rhodanese-like domain Methyltransf_23 PF13489.6 CCF53175.1 - 0.011 15.6 0.0 0.032 14.1 0.0 1.8 2 1 0 2 2 2 0 Methyltransferase domain SecB PF02556.14 CCF53175.1 - 0.064 13.1 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 Preprotein translocase subunit SecB AAA_33 PF13671.6 CCF53176.1 - 0.00024 21.3 0.1 0.09 12.9 0.0 2.2 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.6 CCF53176.1 - 0.00082 19.9 0.3 0.0056 17.2 0.3 2.1 1 1 0 1 1 1 1 AAA domain PRK PF00485.18 CCF53176.1 - 0.002 17.9 0.0 0.0037 17.0 0.0 1.4 1 1 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family MeaB PF03308.16 CCF53176.1 - 0.0055 15.7 0.0 0.0088 15.1 0.0 1.2 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_16 PF13191.6 CCF53176.1 - 0.0072 16.7 0.0 0.01 16.2 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain NB-ARC PF00931.22 CCF53176.1 - 0.0075 15.5 0.0 0.012 14.8 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain KTI12 PF08433.10 CCF53176.1 - 0.029 13.8 0.1 0.045 13.2 0.1 1.2 1 0 0 1 1 1 0 Chromatin associated protein KTI12 NACHT PF05729.12 CCF53176.1 - 0.031 14.2 0.0 0.058 13.3 0.0 1.4 1 0 0 1 1 1 0 NACHT domain DUF2075 PF09848.9 CCF53176.1 - 0.06 12.6 0.0 0.084 12.1 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_22 PF13401.6 CCF53176.1 - 0.13 12.6 0.0 0.29 11.4 0.0 1.6 2 0 0 2 2 2 0 AAA domain AAA_17 PF13207.6 CCF53176.1 - 0.17 12.3 0.1 1.5 9.3 0.0 2.1 2 0 0 2 2 2 0 AAA domain Retrotran_gag_2 PF14223.6 CCF53177.1 - 3.2e-05 23.6 0.9 5.3e-05 22.9 0.3 1.7 2 0 0 2 2 2 1 gag-polypeptide of LTR copia-type SAS4 PF15460.6 CCF53177.1 - 0.27 11.3 1.4 4.1 7.5 0.1 2.5 3 0 0 3 3 3 0 Something about silencing, SAS, complex subunit 4 RVT_2 PF07727.14 CCF53178.1 - 4.1e-28 98.7 0.1 6.2e-28 98.1 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Lipoprotein_8 PF02030.15 CCF53178.1 - 0.18 10.5 0.4 0.27 9.9 0.4 1.2 1 0 0 1 1 1 0 Hypothetical lipoprotein (MG045 family) DUF3292 PF11696.8 CCF53179.1 - 9.6e-06 24.3 0.8 9.6e-06 24.3 0.8 4.3 5 0 0 5 5 5 2 Protein of unknown function (DUF3292) PRT_C PF08372.10 CCF53179.1 - 0.003 17.3 4.5 0.53 10.0 0.8 2.3 1 1 1 2 2 2 2 Plant phosphoribosyltransferase C-terminal Reticulon PF02453.17 CCF53179.1 - 0.0048 16.9 2.0 2.2 8.2 0.0 2.2 2 0 0 2 2 2 2 Reticulon GRAM PF02893.20 CCF53179.1 - 0.046 13.6 0.0 0.13 12.1 0.0 1.7 1 0 0 1 1 1 0 GRAM domain DUF2214 PF09980.9 CCF53179.1 - 0.18 11.6 0.3 0.36 10.6 0.3 1.5 1 0 0 1 1 1 0 Predicted membrane protein (DUF2214) Sigma_reg_N PF13800.6 CCF53180.1 - 0.11 12.7 0.2 0.22 11.9 0.1 1.7 2 0 0 2 2 2 0 Sigma factor regulator N-terminal Polysacc_deac_1 PF01522.21 CCF53182.1 - 1.5e-29 102.4 0.0 2.3e-29 101.8 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide deacetylase Tma16 PF11176.8 CCF53184.1 - 4.1e-41 140.3 0.0 5.9e-41 139.8 0.0 1.2 1 0 0 1 1 1 1 Translation machinery-associated protein 16 RTA1 PF04479.13 CCF53185.1 - 3.1e-41 141.3 11.0 6.5e-32 110.8 1.8 3.0 3 0 0 3 3 3 2 RTA1 like protein Zn_clus PF00172.18 CCF53186.1 - 0.014 15.5 7.5 0.014 15.5 7.5 1.8 2 0 0 2 2 2 0 Fungal Zn(2)-Cys(6) binuclear cluster domain MatP_C PF17414.2 CCF53186.1 - 0.12 12.6 0.1 0.43 10.8 0.1 1.9 1 0 0 1 1 1 0 MatP C-terminal ribbon-helix-helix domain GMC_oxred_N PF00732.19 CCF53187.1 - 3.1e-42 145.0 0.1 4.9e-42 144.3 0.1 1.4 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 CCF53187.1 - 1.6e-21 77.3 2.2 5.7e-21 75.5 0.0 2.9 3 1 0 3 3 3 1 GMC oxidoreductase FAD_binding_2 PF00890.24 CCF53187.1 - 2.5e-07 30.2 3.7 0.0024 17.0 1.1 2.2 2 0 0 2 2 2 2 FAD binding domain FAD_binding_3 PF01494.19 CCF53187.1 - 3.8e-05 23.1 0.3 7e-05 22.2 0.3 1.4 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 CCF53187.1 - 0.00071 18.9 0.6 0.0045 16.2 0.2 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CCF53187.1 - 0.00076 19.2 2.1 0.88 9.1 0.7 2.3 2 0 0 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CCF53187.1 - 0.0024 18.1 1.4 0.0063 16.7 1.4 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain ThiF PF00899.21 CCF53187.1 - 0.024 14.0 0.1 0.054 12.9 0.1 1.5 1 0 0 1 1 1 0 ThiF family GIDA PF01134.22 CCF53187.1 - 0.037 13.1 0.1 0.073 12.1 0.1 1.4 1 0 0 1 1 1 0 Glucose inhibited division protein A HI0933_like PF03486.14 CCF53187.1 - 0.091 11.5 0.4 0.42 9.3 0.2 1.9 2 0 0 2 2 2 0 HI0933-like protein FAD_oxidored PF12831.7 CCF53187.1 - 0.094 12.0 1.5 0.15 11.3 1.5 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase Thi4 PF01946.17 CCF53187.1 - 0.11 11.7 0.4 0.21 10.8 0.4 1.3 1 0 0 1 1 1 0 Thi4 family Amidohydro_2 PF04909.14 CCF53189.1 - 2.3e-39 135.9 1.4 3.1e-39 135.5 1.4 1.1 1 0 0 1 1 1 1 Amidohydrolase Acetyltransf_1 PF00583.25 CCF53190.1 - 7.8e-11 42.2 0.0 9.1e-11 42.0 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 CCF53190.1 - 4.5e-09 36.6 0.0 6.8e-09 36.0 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 CCF53190.1 - 2.2e-08 34.1 0.0 2.5e-08 33.9 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 CCF53190.1 - 0.0016 18.6 0.0 0.0022 18.2 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain PanZ PF12568.8 CCF53190.1 - 0.043 13.5 0.0 0.061 13.1 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain, PanZ ABC_tran PF00005.27 CCF53191.1 - 9.8e-50 168.6 0.7 2.2e-26 93.0 0.1 2.4 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 CCF53191.1 - 3.8e-32 112.0 23.7 2e-24 86.7 10.1 2.5 2 0 0 2 2 2 2 ABC transporter transmembrane region SMC_N PF02463.19 CCF53191.1 - 1.6e-11 44.1 1.1 0.00012 21.6 0.0 3.0 2 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CCF53191.1 - 2.6e-06 27.1 0.2 0.029 14.1 0.0 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 CCF53191.1 - 8.1e-06 25.8 0.2 0.2 11.6 0.0 3.1 2 1 0 2 2 2 2 RsgA GTPase AAA_22 PF13401.6 CCF53191.1 - 1.2e-05 25.6 1.9 0.1 12.8 1.0 3.3 2 1 0 2 2 2 2 AAA domain AAA_21 PF13304.6 CCF53191.1 - 8.9e-05 22.4 1.0 9.9 5.9 0.0 4.2 3 1 0 4 4 4 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 CCF53191.1 - 0.00094 19.7 0.1 0.15 12.5 0.0 2.4 2 0 0 2 2 2 1 AAA domain FtsK_SpoIIIE PF01580.18 CCF53191.1 - 0.0022 17.4 0.0 2.2 7.6 0.0 2.5 2 0 0 2 2 2 2 FtsK/SpoIIIE family AAA_30 PF13604.6 CCF53191.1 - 0.0025 17.6 0.3 0.045 13.5 0.1 2.5 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 CCF53191.1 - 0.0076 16.3 0.0 2.5 8.2 0.0 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA PF00004.29 CCF53191.1 - 0.0079 16.6 1.9 2.1 8.8 0.7 3.7 2 2 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 CCF53191.1 - 0.014 15.8 4.1 1.1 9.6 0.3 2.9 2 1 0 2 2 2 0 AAA ATPase domain AAA_33 PF13671.6 CCF53191.1 - 0.027 14.6 0.3 13 5.9 0.2 2.8 2 1 0 2 2 2 0 AAA domain AAA_15 PF13175.6 CCF53191.1 - 0.028 14.1 0.0 1.5 8.4 0.0 2.3 2 0 0 2 2 2 0 AAA ATPase domain AAA_25 PF13481.6 CCF53191.1 - 0.029 13.9 0.2 14 5.2 0.0 3.0 3 0 0 3 3 3 0 AAA domain ABC_ATPase PF09818.9 CCF53191.1 - 0.052 12.3 6.4 0.074 11.8 0.0 2.5 3 0 0 3 3 3 0 Predicted ATPase of the ABC class PsbY PF06298.11 CCF53191.1 - 0.074 13.0 2.3 0.098 12.6 0.1 2.4 2 0 0 2 2 2 0 Photosystem II protein Y (PsbY) RNA_helicase PF00910.22 CCF53191.1 - 0.079 13.3 0.1 54 4.2 0.0 3.4 3 0 0 3 3 3 0 RNA helicase Dynamin_N PF00350.23 CCF53191.1 - 0.084 12.9 0.2 0.4 10.7 0.0 2.1 2 0 0 2 2 2 0 Dynamin family NB-ARC PF00931.22 CCF53191.1 - 0.087 12.0 3.9 5.2 6.2 0.0 3.5 3 1 0 3 3 3 0 NB-ARC domain SbcCD_C PF13558.6 CCF53191.1 - 0.12 12.6 0.3 5.3 7.4 0.0 3.1 2 0 0 2 2 2 0 Putative exonuclease SbcCD, C subunit cobW PF02492.19 CCF53191.1 - 0.19 11.3 0.8 1.4 8.5 0.0 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain MARVEL PF01284.23 CCF53192.1 - 5.3e-09 36.3 4.1 8.9e-09 35.5 4.1 1.3 1 0 0 1 1 1 1 Membrane-associating domain MSP1a PF11670.8 CCF53192.1 - 0.089 12.1 0.1 0.14 11.4 0.1 1.2 1 0 0 1 1 1 0 Major surface protein 1a (MSP1a) DUF973 PF06157.11 CCF53192.1 - 0.1 11.6 1.2 0.14 11.2 1.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF973) DUF1772 PF08592.11 CCF53192.1 - 0.3 11.4 3.3 0.26 11.6 2.0 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF1772) Cmc1 PF08583.10 CCF53193.1 - 2.4e-13 49.9 1.3 2.9e-13 49.6 1.3 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like NDUF_B7 PF05676.13 CCF53193.1 - 0.00029 20.5 0.5 0.0004 20.0 0.5 1.2 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) Pet191_N PF10203.9 CCF53193.1 - 0.044 14.1 0.8 2.6 8.4 0.1 2.1 2 0 0 2 2 2 0 Cytochrome c oxidase assembly protein PET191 DUF3128 PF11326.8 CCF53193.1 - 0.31 11.4 4.3 0.7 10.3 4.3 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3128) UCR_hinge PF02320.16 CCF53193.1 - 0.35 11.1 5.6 5.3 7.3 0.6 2.3 1 1 1 2 2 2 0 Ubiquinol-cytochrome C reductase hinge protein DUF2237 PF09996.9 CCF53194.1 - 1.3e-26 92.8 0.0 1.7e-26 92.5 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2237) LRR_8 PF13855.6 CCF53195.1 - 5e-14 51.8 14.4 2.3e-09 36.8 4.2 4.2 2 1 2 4 4 4 3 Leucine rich repeat LRR_9 PF14580.6 CCF53195.1 - 6.9e-10 38.7 2.8 2.1e-05 24.1 0.5 2.6 2 0 0 2 2 2 2 Leucine-rich repeat LRR_4 PF12799.7 CCF53195.1 - 2.3e-09 37.4 27.5 2.3e-05 24.7 2.2 5.6 4 2 2 6 6 6 3 Leucine Rich repeats (2 copies) AA_permease_2 PF13520.6 CCF53196.1 - 1.2e-59 202.3 37.4 1.5e-59 202.0 37.4 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 CCF53196.1 - 2.1e-24 86.0 32.2 2.6e-24 85.7 32.2 1.1 1 0 0 1 1 1 1 Amino acid permease FDF PF09532.10 CCF53197.1 - 0.00023 22.0 0.0 0.00097 20.0 0.0 2.1 1 0 0 1 1 1 1 FDF domain LBR_tudor PF09465.10 CCF53197.1 - 0.0083 15.9 0.0 0.015 15.1 0.0 1.4 1 0 0 1 1 1 1 Lamin-B receptor of TUDOR domain NUDIX PF00293.28 CCF53198.1 - 1.8e-10 41.0 0.1 3.9e-10 39.9 0.0 1.5 2 0 0 2 2 2 1 NUDIX domain DnaJ_C PF01556.18 CCF53199.1 - 1.9e-36 125.4 0.7 2.9e-36 124.8 0.7 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 CCF53199.1 - 3.2e-23 81.6 1.1 5.9e-23 80.8 1.1 1.5 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 CCF53199.1 - 3.4e-14 52.9 19.0 5.9e-14 52.2 19.0 1.4 1 0 0 1 1 1 1 DnaJ central domain Cytochrom_c3_2 PF14537.6 CCF53199.1 - 0.21 12.1 13.2 0.62 10.6 5.6 2.3 1 1 1 2 2 2 0 Cytochrome c3 Anti-TRAP PF15777.5 CCF53199.1 - 0.24 11.4 17.7 0.076 13.0 4.6 2.7 1 1 1 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein Cytochrome_C7 PF14522.6 CCF53199.1 - 1.5 8.8 12.9 13 5.9 13.4 2.0 1 1 1 2 2 2 0 Cytochrome c7 and related cytochrome c HypA PF01155.19 CCF53199.1 - 5 7.2 14.1 1.7 8.7 4.5 2.4 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DcpS_C PF11969.8 CCF53200.1 - 1.7e-27 96.1 0.8 1.7e-27 96.1 0.8 1.5 2 0 0 2 2 2 1 Scavenger mRNA decapping enzyme C-term binding DcpS PF05652.12 CCF53200.1 - 8.4e-25 87.6 0.0 2.1e-24 86.3 0.0 1.7 1 1 0 1 1 1 1 Scavenger mRNA decapping enzyme (DcpS) N-terminal HIT PF01230.23 CCF53200.1 - 0.15 12.8 0.7 0.39 11.5 0.7 1.7 1 0 0 1 1 1 0 HIT domain UPF0240 PF06784.11 CCF53201.1 - 0.12 12.4 4.6 0.36 10.9 4.6 2.0 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0240) Glyco_hydro_85 PF03644.13 CCF53202.1 - 3.2e-92 309.2 0.0 4.7e-92 308.6 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 85 DUF2470 PF10615.9 CCF53203.1 - 9.4e-19 67.8 0.0 1.7e-18 67.0 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2470) DUF4499 PF14934.6 CCF53203.1 - 6.8e-07 29.5 0.4 1.2e-06 28.8 0.4 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4499) FAA_hydrolase PF01557.18 CCF53204.1 - 1e-54 185.5 0.0 1.2e-54 185.2 0.0 1.0 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family CoA_binding_2 PF13380.6 CCF53205.1 - 2.3e-25 89.3 0.0 2.7e-25 89.1 0.0 1.0 1 0 0 1 1 1 1 CoA binding domain Herpes_gp2 PF05955.11 CCF53205.1 - 0.12 11.9 0.0 0.16 11.5 0.0 1.2 1 0 0 1 1 1 0 Equine herpesvirus glycoprotein gp2 Aldose_epim PF01263.20 CCF53206.1 - 6.8e-57 193.1 0.5 8.1e-57 192.8 0.5 1.1 1 0 0 1 1 1 1 Aldose 1-epimerase Glyco_hydro_92 PF07971.12 CCF53208.1 - 1.6e-141 472.4 0.2 1.9e-141 472.1 0.2 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 Glyco_hydro_92N PF17678.1 CCF53208.1 - 7.2e-38 130.8 3.0 1.2e-37 130.1 3.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 N-terminal domain DUF1275 PF06912.11 CCF53209.1 - 2.9e-20 73.0 14.0 4.2e-20 72.5 13.7 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF1275) CarS-like PF01864.17 CCF53209.1 - 0.02 14.9 0.2 0.05 13.6 0.2 1.6 1 1 0 1 1 1 0 CDP-archaeol synthase GFO_IDH_MocA PF01408.22 CCF53210.1 - 2.3e-14 54.2 0.0 4.3e-14 53.4 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 CCF53210.1 - 6.4e-12 45.5 0.0 1.2e-11 44.7 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain CRA_rpt PF07046.11 CCF53210.1 - 0.084 13.0 5.8 0.18 12.0 5.8 1.4 1 0 0 1 1 1 0 Cytoplasmic repetitive antigen (CRA) like repeat SNase PF00565.17 CCF53211.1 - 1.3e-19 70.6 0.8 3.3e-08 34.0 0.5 3.2 2 1 0 2 2 2 2 Staphylococcal nuclease homologue PQ-loop PF04193.14 CCF53212.1 - 9.8e-25 86.1 7.5 5.2e-13 48.6 0.7 2.8 3 0 0 3 3 3 2 PQ loop repeat DUF4299 PF14132.6 CCF53212.1 - 0.016 14.6 0.0 0.04 13.3 0.0 1.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4299) SelP_N PF04592.14 CCF53213.1 - 1.1 8.6 12.6 2 7.7 12.6 1.3 1 0 0 1 1 1 0 Selenoprotein P, N terminal region RRN3 PF05327.11 CCF53215.1 - 6.6 5.2 6.6 12 4.3 6.6 1.6 1 1 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Transthyretin PF00576.21 CCF53216.1 - 4.3e-39 133.6 0.0 4.9e-39 133.4 0.0 1.0 1 0 0 1 1 1 1 HIUase/Transthyretin family bMG3 PF11974.8 CCF53216.1 - 0.024 14.7 0.1 0.04 13.9 0.1 1.4 1 1 0 1 1 1 0 Bacterial alpha-2-macroglobulin MG3 domain Mito_carr PF00153.27 CCF53217.1 - 3.6e-49 164.6 4.8 3.2e-16 59.0 0.1 3.4 3 1 0 3 3 3 3 Mitochondrial carrier protein IU_nuc_hydro PF01156.19 CCF53218.1 - 3e-60 204.4 0.1 3.9e-60 204.0 0.1 1.1 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase DUF5549 PF17703.1 CCF53218.1 - 0.085 12.5 0.1 0.13 11.9 0.1 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5549) GSHPx PF00255.19 CCF53219.1 - 8.1e-41 138.0 0.9 1e-40 137.6 0.9 1.1 1 0 0 1 1 1 1 Glutathione peroxidase AhpC-TSA PF00578.21 CCF53219.1 - 8.7e-07 28.9 0.2 6e-06 26.2 0.2 2.0 1 1 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 CCF53219.1 - 5.9e-06 26.0 0.0 1.2e-05 25.0 0.0 1.6 1 1 0 1 1 1 1 Redoxin Caleosin PF05042.13 CCF53219.1 - 0.047 13.6 0.0 0.075 13.0 0.0 1.2 1 0 0 1 1 1 0 Caleosin related protein S-methyl_trans PF02574.16 CCF53222.1 - 7.5e-42 144.0 0.0 2.8e-41 142.1 0.0 1.7 1 1 0 1 1 1 1 Homocysteine S-methyltransferase Polysacc_deac_1 PF01522.21 CCF53223.1 - 3e-25 88.5 0.0 5e-25 87.8 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide deacetylase Glyco_hydro_57 PF03065.15 CCF53223.1 - 0.11 11.7 0.0 0.16 11.1 0.0 1.4 1 0 0 1 1 1 0 Glycosyl hydrolase family 57 Erg28 PF03694.13 CCF53224.1 - 1.7e-36 124.9 1.6 2.2e-36 124.6 1.6 1.1 1 0 0 1 1 1 1 Erg28 like protein DNA_ligase_OB_2 PF14743.6 CCF53225.1 - 2.2e-23 82.1 0.0 5.2e-23 80.8 0.0 1.7 1 0 0 1 1 1 1 DNA ligase OB-like domain DNA_ligase_A_M PF01068.21 CCF53225.1 - 2e-07 30.9 0.0 2.9e-05 23.8 0.0 2.3 2 0 0 2 2 2 2 ATP dependent DNA ligase domain RNA_ligase PF09414.10 CCF53225.1 - 0.032 14.5 0.0 14 6.0 0.0 2.6 2 1 0 2 2 2 0 RNA ligase Abhydrolase_3 PF07859.13 CCF53226.1 - 5.6e-39 134.2 0.0 9.2e-32 110.6 0.0 2.7 2 0 0 2 2 2 2 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 CCF53226.1 - 1.7e-09 37.0 0.0 3.6e-08 32.7 0.5 2.5 2 1 0 2 2 2 1 Steryl acetyl hydrolase AXE1 PF05448.12 CCF53226.1 - 0.029 13.0 0.1 0.055 12.1 0.1 1.3 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) Peptidase_S9 PF00326.21 CCF53226.1 - 0.053 13.0 0.0 0.11 12.0 0.0 1.4 1 0 0 1 1 1 0 Prolyl oligopeptidase family COesterase PF00135.28 CCF53226.1 - 0.14 11.0 0.0 3 6.6 0.0 2.3 2 0 0 2 2 2 0 Carboxylesterase family Spem1 PF15670.5 CCF53226.1 - 0.49 9.9 7.1 1.6 8.3 7.1 1.9 1 0 0 1 1 1 0 Spermatid maturation protein 1 Aldo_ket_red PF00248.21 CCF53228.1 - 6.6e-65 219.2 0.0 8e-65 218.9 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family A_deaminase PF00962.22 CCF53229.1 - 5.3e-26 91.7 0.0 1.6e-25 90.1 0.0 1.7 1 1 0 1 1 1 1 Adenosine/AMP deaminase Sulfotransfer_3 PF13469.6 CCF53230.1 - 0.016 15.6 0.0 0.47 10.8 0.0 2.7 2 2 0 2 2 2 0 Sulfotransferase family Mg_trans_NIPA PF05653.14 CCF53231.1 - 3.7e-91 305.3 28.9 4.9e-91 304.9 28.9 1.1 1 0 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.20 CCF53231.1 - 7.2e-05 23.0 11.6 7.2e-05 23.0 11.6 3.2 2 2 0 2 2 2 1 EamA-like transporter family WSN PF02206.18 CCF53231.1 - 0.033 14.1 0.5 0.072 13.0 0.5 1.5 1 0 0 1 1 1 0 Domain of unknown function Hydrolase PF00702.26 CCF53231.1 - 0.32 11.2 1.6 0.8 9.9 0.0 2.0 1 1 1 2 2 2 0 haloacid dehalogenase-like hydrolase Dodecin PF07311.12 CCF53231.1 - 4.7 7.5 5.1 11 6.4 5.1 1.5 1 0 0 1 1 1 0 Dodecin PGPGW PF09656.10 CCF53231.1 - 6.7 6.3 8.0 20 4.8 2.8 3.3 2 0 0 2 2 2 0 Putative transmembrane protein (PGPGW) Mito_carr PF00153.27 CCF53232.1 - 8.3e-50 166.7 3.8 2.7e-17 62.5 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF1834 PF08873.11 CCF53232.1 - 0.035 13.8 0.0 0.068 12.9 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1834) START PF01852.19 CCF53233.1 - 9.8e-13 48.0 0.2 1.5e-12 47.3 0.2 1.3 1 0 0 1 1 1 1 START domain TMEM52 PF14979.6 CCF53233.1 - 0.065 13.2 0.1 0.13 12.2 0.1 1.4 1 0 0 1 1 1 0 Transmembrane 52 MoaE PF02391.17 CCF53234.1 - 1.1e-38 132.0 0.0 1.4e-38 131.7 0.0 1.1 1 0 0 1 1 1 1 MoaE protein Ribonuclease PF00545.20 CCF53235.1 - 1e-08 35.8 0.6 1.3e-08 35.5 0.6 1.1 1 0 0 1 1 1 1 ribonuclease Thioredoxin PF00085.20 CCF53236.1 - 3.4e-59 197.2 0.1 2.3e-29 101.4 0.0 2.5 2 0 0 2 2 2 2 Thioredoxin ERp29 PF07749.12 CCF53236.1 - 1.7e-21 76.9 1.6 1.7e-21 76.9 1.6 2.5 3 0 0 3 3 2 1 Endoplasmic reticulum protein ERp29, C-terminal domain OST3_OST6 PF04756.13 CCF53236.1 - 1.6e-16 60.5 0.0 1.5e-07 31.1 0.1 2.4 1 1 1 2 2 2 2 OST3 / OST6 family, transporter family Thioredoxin_2 PF13098.6 CCF53236.1 - 6.3e-12 45.9 1.5 6.5e-05 23.4 0.2 3.7 2 2 0 2 2 2 2 Thioredoxin-like domain Thioredoxin_8 PF13905.6 CCF53236.1 - 5.9e-09 36.1 2.5 0.039 14.3 0.0 4.6 4 1 1 5 5 5 2 Thioredoxin-like AhpC-TSA PF00578.21 CCF53236.1 - 4.9e-08 32.9 0.7 0.012 15.5 0.0 3.0 3 0 0 3 3 3 2 AhpC/TSA family Thioredoxin_7 PF13899.6 CCF53236.1 - 3.3e-06 27.2 1.1 0.0032 17.6 0.1 3.1 3 0 0 3 3 3 2 Thioredoxin-like TraF PF13728.6 CCF53236.1 - 1.7e-05 24.8 1.6 0.0032 17.3 0.0 3.1 3 0 0 3 3 3 1 F plasmid transfer operon protein HyaE PF07449.11 CCF53236.1 - 8.2e-05 22.5 0.0 0.019 15.0 0.0 2.6 2 0 0 2 2 2 1 Hydrogenase-1 expression protein HyaE Thioredoxin_9 PF14595.6 CCF53236.1 - 0.0011 18.8 0.5 1.3 8.8 0.0 2.7 3 0 0 3 3 3 2 Thioredoxin Redoxin PF08534.10 CCF53236.1 - 0.0012 18.5 3.4 0.33 10.7 0.0 2.8 3 0 0 3 3 3 2 Redoxin Transcrip_act PF04949.13 CCF53236.1 - 0.022 14.6 7.5 0.036 14.0 7.5 1.3 1 0 0 1 1 1 0 Transcriptional activator Propeptide_C1 PF08127.13 CCF53236.1 - 0.12 12.3 0.2 18 5.3 0.0 2.7 2 0 0 2 2 2 0 Peptidase family C1 propeptide LMBR1 PF04791.16 CCF53236.1 - 0.17 10.8 2.9 0.83 8.5 0.3 2.0 2 0 0 2 2 2 0 LMBR1-like membrane protein Thioredoxin_4 PF13462.6 CCF53236.1 - 0.21 11.8 8.5 3.4 7.8 0.0 3.8 3 1 0 3 3 3 0 Thioredoxin NCA2 PF08637.10 CCF53237.1 - 1.1e-81 274.2 0.1 1.1e-81 274.2 0.1 2.6 3 0 0 3 3 3 1 ATP synthase regulation protein NCA2 DUF2268 PF10026.9 CCF53237.1 - 0.17 11.4 0.0 0.31 10.6 0.0 1.4 1 0 0 1 1 1 0 Predicted Zn-dependent protease (DUF2268) Aminotran_1_2 PF00155.21 CCF53239.1 - 1.3e-17 64.0 0.0 1.6e-17 63.7 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_MocR PF12897.7 CCF53239.1 - 1.1e-07 31.1 0.0 3.2e-07 29.5 0.0 1.5 2 1 0 2 2 2 1 Alanine-glyoxylate amino-transferase Frag1 PF10277.9 CCF53240.1 - 1.9e-38 132.2 19.6 2.3e-38 132.0 19.6 1.0 1 0 0 1 1 1 1 Frag1/DRAM/Sfk1 family TarH PF02203.15 CCF53240.1 - 0.33 10.9 0.7 1.3 8.9 0.4 1.9 2 0 0 2 2 2 0 Tar ligand binding domain homologue Cation_ATPase_C PF00689.21 CCF53240.1 - 3.2 7.4 14.4 5.9 6.6 8.7 2.2 1 1 1 2 2 2 0 Cation transporting ATPase, C-terminus DUF4227 PF14004.6 CCF53240.1 - 10 6.2 7.3 17 5.5 0.3 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF4227) XPG_I_2 PF12813.7 CCF53241.1 - 2.8e-08 33.6 0.1 4e-07 29.8 0.1 2.2 1 1 0 1 1 1 1 XPG domain containing XPG_N PF00752.17 CCF53241.1 - 0.00011 22.6 0.0 0.0075 16.7 0.0 2.4 2 0 0 2 2 2 1 XPG N-terminal domain 5_3_exonuc_N PF02739.16 CCF53241.1 - 0.0015 18.4 0.0 1.4 8.8 0.0 2.3 2 0 0 2 2 2 2 5'-3' exonuclease, N-terminal resolvase-like domain Tub_N PF16322.5 CCF53241.1 - 0.051 14.0 2.6 0.094 13.1 2.6 1.4 1 0 0 1 1 1 0 Tubby N-terminal PTPRCAP PF15713.5 CCF53241.1 - 0.18 12.1 5.4 0.48 10.7 5.4 1.7 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated Pox_RNA_Pol_19 PF05320.12 CCF53241.1 - 0.54 10.2 3.9 6.5 6.7 0.0 2.3 2 0 0 2 2 2 0 Poxvirus DNA-directed RNA polymerase 19 kDa subunit Nop14 PF04147.12 CCF53241.1 - 2.1 6.5 5.6 2.7 6.1 5.6 1.1 1 0 0 1 1 1 0 Nop14-like family CENP-B_dimeris PF09026.10 CCF53241.1 - 4.3 7.8 15.0 0.097 13.1 7.6 2.0 2 0 0 2 2 2 0 Centromere protein B dimerisation domain Lactamase_B PF00753.27 CCF53242.1 - 4.4e-15 56.2 2.6 1.3e-14 54.7 2.6 1.8 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily BLACT_WH PF17778.1 CCF53242.1 - 2.2e-06 27.5 0.1 8e-06 25.7 0.0 1.9 2 0 0 2 2 2 1 Beta-lactamase associated winged helix domain Lactamase_B_2 PF12706.7 CCF53242.1 - 0.0016 18.0 0.2 0.0045 16.5 0.1 1.8 2 0 0 2 2 2 1 Beta-lactamase superfamily domain Evr1_Alr PF04777.13 CCF53243.1 - 5.4e-28 97.4 0.1 9.9e-28 96.6 0.1 1.4 1 0 0 1 1 1 1 Erv1 / Alr family Glyco_hydro_cc PF11790.8 CCF53244.1 - 1.6e-44 152.2 0.0 2.5e-44 151.6 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase catalytic core SARAF PF06682.12 CCF53244.1 - 0.54 9.9 19.5 0.86 9.2 19.5 1.3 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis BUD22 PF09073.10 CCF53244.1 - 0.92 8.8 21.1 1.3 8.2 21.1 1.1 1 0 0 1 1 1 0 BUD22 Presenilin PF01080.17 CCF53244.1 - 5 5.8 11.4 8.9 5.0 11.4 1.4 1 0 0 1 1 1 0 Presenilin Hid1 PF12722.7 CCF53244.1 - 6.9 4.7 10.7 10 4.1 10.7 1.3 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Band_3_cyto PF07565.13 CCF53244.1 - 6.9 6.4 9.1 11 5.7 9.1 1.3 1 0 0 1 1 1 0 Band 3 cytoplasmic domain SelP_N PF04592.14 CCF53244.1 - 8.6 5.7 15.2 14 5.0 15.2 1.3 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Aldose_epim PF01263.20 CCF53245.1 - 9.2e-16 58.0 0.0 1.9e-13 50.4 0.0 3.0 1 1 0 1 1 1 1 Aldose 1-epimerase CIA30 PF08547.12 CCF53246.1 - 1.7e-24 86.6 0.0 5.9e-11 42.6 0.0 2.2 2 0 0 2 2 2 2 Complex I intermediate-associated protein 30 (CIA30) SGBP_B_XBD PF18329.1 CCF53246.1 - 0.052 13.5 0.0 0.094 12.7 0.0 1.3 1 0 0 1 1 1 0 Surface glycan-binding protein B xyloglucan binding domain His_Phos_2 PF00328.22 CCF53247.1 - 2.1e-05 24.1 0.0 0.0037 16.7 0.0 2.6 1 1 1 2 2 2 2 Histidine phosphatase superfamily (branch 2) WzyE PF06899.11 CCF53247.1 - 0.17 10.8 0.0 0.26 10.2 0.0 1.3 1 0 0 1 1 1 0 WzyE protein, O-antigen assembly polymerase Acatn PF13000.7 CCF53248.1 - 1.1e-158 529.1 25.3 1.3e-77 261.6 16.8 3.5 1 1 2 3 3 3 3 Acetyl-coenzyme A transporter 1 DUF2423 PF10338.9 CCF53248.1 - 0.013 15.7 1.8 0.022 15.0 1.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2423) Peptidase_M48 PF01435.18 CCF53249.1 - 1.7e-31 109.6 0.0 3.3e-31 108.6 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M48 HTH_1 PF00126.27 CCF53249.1 - 0.057 13.4 0.2 3.7 7.6 0.0 2.8 2 0 0 2 2 2 0 Bacterial regulatory helix-turn-helix protein, lysR family adh_short PF00106.25 CCF53250.1 - 1.8e-22 79.8 1.7 1.1e-09 38.0 0.1 3.1 2 1 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CCF53250.1 - 6.1e-13 48.9 0.3 1.4e-06 28.0 0.0 2.4 3 0 0 3 3 3 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF53250.1 - 0.0015 18.5 0.0 0.0033 17.4 0.0 1.6 1 1 0 1 1 1 1 KR domain FtsJ PF01728.19 CCF53251.1 - 3.4e-63 212.9 0.0 5e-63 212.4 0.0 1.2 1 0 0 1 1 1 1 FtsJ-like methyltransferase rRNA_processing PF08524.11 CCF53252.1 - 3.8e-10 40.0 12.1 2.2e-05 24.5 0.1 2.3 2 0 0 2 2 2 2 rRNA processing Methyltransf_PK PF05891.12 CCF53253.1 - 5.9e-60 202.5 0.0 2.5e-34 118.7 0.0 3.0 3 0 0 3 3 3 3 AdoMet dependent proline di-methyltransferase Methyltransf_23 PF13489.6 CCF53253.1 - 3e-09 36.9 0.0 4.2e-09 36.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF53253.1 - 1.6e-07 31.9 0.0 0.00047 20.8 0.0 2.4 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_11 PF08241.12 CCF53253.1 - 3.4e-06 27.6 0.0 0.0007 20.2 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF53253.1 - 5.8e-06 27.0 0.0 0.0046 17.7 0.0 2.3 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_2 PF00891.18 CCF53253.1 - 0.0048 16.2 0.0 0.0078 15.5 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase domain DUF1179 PF06678.11 CCF53253.1 - 0.17 11.9 0.5 0.32 11.0 0.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1179) GRDP-like PF07173.12 CCF53254.1 - 2e-08 35.0 1.6 4.2e-05 24.2 0.7 4.1 2 1 2 4 4 4 3 Glycine-rich domain-containing protein-like PSCyt2 PF07583.11 CCF53254.1 - 0.089 12.7 0.0 0.19 11.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1549) WRKY PF03106.15 CCF53255.1 - 0.89 9.8 4.4 10 6.5 1.9 2.2 2 0 0 2 2 2 0 WRKY DNA -binding domain adh_short_C2 PF13561.6 CCF53256.1 - 2.7e-55 187.5 4.3 1e-44 152.9 3.0 2.0 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCF53256.1 - 7.1e-50 169.2 3.6 8.6e-50 168.9 3.6 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CCF53256.1 - 2e-11 44.1 1.7 3.4e-11 43.4 1.7 1.4 1 1 0 1 1 1 1 KR domain 3HCDH_N PF02737.18 CCF53256.1 - 0.004 17.0 0.7 0.0068 16.3 0.7 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Shikimate_DH PF01488.20 CCF53256.1 - 0.03 14.4 0.0 0.066 13.3 0.0 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase 2-Hacid_dh_C PF02826.19 CCF53256.1 - 0.044 13.2 0.1 0.084 12.2 0.1 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain UDPG_MGDP_dh_N PF03721.14 CCF53256.1 - 0.13 11.8 0.3 0.2 11.2 0.3 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Peptidase_M24 PF00557.24 CCF53257.1 - 1.5e-45 155.4 0.0 1.9e-45 155.1 0.0 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 Abhydrolase_1 PF00561.20 CCF53258.1 - 6.2e-14 52.3 0.2 8.9e-13 48.5 0.2 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CCF53258.1 - 2.3e-12 48.0 0.0 3.4e-12 47.5 0.0 1.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CCF53258.1 - 1.1e-09 37.9 0.0 1.6e-09 37.4 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 PGAP1 PF07819.13 CCF53258.1 - 4.2e-09 36.5 0.4 6.2e-07 29.4 0.2 2.8 2 1 0 2 2 2 1 PGAP1-like protein Thioesterase PF00975.20 CCF53258.1 - 1.5e-06 28.5 0.0 2.6e-06 27.8 0.0 1.5 1 1 0 1 1 1 1 Thioesterase domain DUF676 PF05057.14 CCF53258.1 - 0.0026 17.3 0.0 0.0042 16.6 0.0 1.3 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Chlorophyllase2 PF12740.7 CCF53258.1 - 0.017 14.0 0.0 0.028 13.3 0.0 1.3 1 0 0 1 1 1 0 Chlorophyllase enzyme DLH PF01738.18 CCF53258.1 - 0.039 13.5 0.0 0.1 12.1 0.0 1.6 1 1 1 2 2 2 0 Dienelactone hydrolase family Abhydrolase_5 PF12695.7 CCF53258.1 - 0.052 13.3 0.0 1.2 8.8 0.0 2.2 2 0 0 2 2 2 0 Alpha/beta hydrolase family AAA_33 PF13671.6 CCF53260.1 - 0.00036 20.7 0.0 0.00059 20.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain MobB PF03205.14 CCF53260.1 - 0.0005 20.0 0.0 0.0016 18.4 0.0 1.7 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B SRP54 PF00448.22 CCF53260.1 - 0.00097 18.8 0.0 0.0022 17.6 0.0 1.6 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain AAA_16 PF13191.6 CCF53260.1 - 0.0037 17.7 0.0 0.0068 16.8 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain MeaB PF03308.16 CCF53260.1 - 0.0046 16.0 0.0 0.0079 15.2 0.0 1.3 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB TsaE PF02367.17 CCF53260.1 - 0.0053 16.8 0.0 0.011 15.7 0.0 1.5 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE Cytidylate_kin PF02224.18 CCF53260.1 - 0.0064 16.3 0.0 0.0095 15.7 0.0 1.3 1 0 0 1 1 1 1 Cytidylate kinase ATP_bind_1 PF03029.17 CCF53260.1 - 0.0072 16.1 0.1 0.011 15.5 0.1 1.2 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein AAA_18 PF13238.6 CCF53260.1 - 0.0076 16.8 0.0 0.017 15.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain ParA PF10609.9 CCF53260.1 - 0.0087 15.5 0.0 0.014 14.9 0.0 1.3 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase APS_kinase PF01583.20 CCF53260.1 - 0.011 15.6 0.0 0.017 15.0 0.0 1.2 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA_11 PF13086.6 CCF53260.1 - 0.011 15.5 0.1 0.017 14.9 0.1 1.2 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 CCF53260.1 - 0.014 14.7 0.0 0.022 14.0 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin NTPase_1 PF03266.15 CCF53260.1 - 0.014 15.3 0.1 0.022 14.7 0.1 1.2 1 0 0 1 1 1 0 NTPase AAA_30 PF13604.6 CCF53260.1 - 0.016 15.0 0.0 0.027 14.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain LpxK PF02606.14 CCF53260.1 - 0.018 14.2 0.0 0.026 13.7 0.0 1.2 1 0 0 1 1 1 0 Tetraacyldisaccharide-1-P 4'-kinase NACHT PF05729.12 CCF53260.1 - 0.02 14.8 0.0 0.03 14.2 0.0 1.3 1 0 0 1 1 1 0 NACHT domain RNA_helicase PF00910.22 CCF53260.1 - 0.023 15.1 0.1 0.062 13.7 0.0 1.8 2 0 0 2 2 1 0 RNA helicase KTI12 PF08433.10 CCF53260.1 - 0.049 13.1 0.0 0.096 12.1 0.0 1.4 1 0 0 1 1 1 0 Chromatin associated protein KTI12 cobW PF02492.19 CCF53260.1 - 0.057 13.0 0.0 0.083 12.5 0.0 1.2 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain ArsA_ATPase PF02374.15 CCF53260.1 - 0.064 12.4 0.2 0.097 11.8 0.2 1.2 1 0 0 1 1 1 0 Anion-transporting ATPase Thymidylate_kin PF02223.17 CCF53260.1 - 0.076 12.7 0.0 0.14 11.9 0.0 1.4 1 0 0 1 1 1 0 Thymidylate kinase CLP1_P PF16575.5 CCF53260.1 - 0.084 12.7 0.1 0.14 11.9 0.1 1.3 1 0 0 1 1 1 0 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_14 PF13173.6 CCF53260.1 - 0.086 12.9 0.0 0.44 10.6 0.0 1.9 2 0 0 2 2 2 0 AAA domain PRK PF00485.18 CCF53260.1 - 0.087 12.6 0.0 0.16 11.7 0.0 1.4 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family CbiA PF01656.23 CCF53260.1 - 0.09 12.8 0.5 0.18 11.9 0.3 1.3 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA PF00004.29 CCF53260.1 - 0.11 12.9 0.0 0.19 12.2 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) ABC_tran PF00005.27 CCF53260.1 - 0.12 12.9 0.0 0.21 12.1 0.0 1.4 1 0 0 1 1 1 0 ABC transporter Torsin PF06309.11 CCF53260.1 - 0.14 12.2 0.1 0.46 10.6 0.0 1.8 1 1 1 2 2 2 0 Torsin AAA_5 PF07728.14 CCF53260.1 - 0.15 12.0 0.1 0.5 10.4 0.0 1.7 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) ATPase_2 PF01637.18 CCF53260.1 - 0.16 11.9 0.0 0.28 11.1 0.0 1.4 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea DUF938 PF06080.12 CCF53261.1 - 3.8e-31 108.5 0.1 1.2e-30 106.8 0.1 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF938) His_Phos_2 PF00328.22 CCF53264.1 - 1.4e-15 57.6 0.0 2.4e-14 53.5 0.0 2.0 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) Fungal_trans PF04082.18 CCF53265.1 - 1.9e-20 73.0 0.9 3.1e-20 72.3 0.1 1.7 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF53265.1 - 9.9e-08 32.0 8.9 1.7e-07 31.3 8.9 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF617 PF04759.13 CCF53265.1 - 0.075 13.1 0.0 0.15 12.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF617 EAF PF09816.9 CCF53266.1 - 1.7e-22 79.7 0.1 4.9e-22 78.2 0.1 1.9 1 0 0 1 1 1 1 RNA polymerase II transcription elongation factor Alpha-L-AF_C PF06964.12 CCF53267.1 - 9.1e-14 51.9 0.1 1.3e-13 51.4 0.1 1.3 1 0 0 1 1 1 1 Alpha-L-arabinofuranosidase C-terminal domain CBM_4_9 PF02018.17 CCF53267.1 - 3.6e-05 24.1 0.0 0.00018 21.8 0.0 2.2 2 0 0 2 2 2 1 Carbohydrate binding domain AMP-binding PF00501.28 CCF53268.1 - 4.6e-27 94.7 0.4 1.2e-26 93.4 0.0 1.8 2 0 0 2 2 2 1 AMP-binding enzyme NAD_binding_4 PF07993.12 CCF53268.1 - 7.8e-25 87.5 0.0 1.4e-24 86.6 0.0 1.4 1 0 0 1 1 1 1 Male sterility protein Epimerase PF01370.21 CCF53268.1 - 1.8e-06 27.6 0.0 3.9e-06 26.5 0.0 1.5 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family KR PF08659.10 CCF53268.1 - 2.4e-05 24.3 0.1 5.4e-05 23.2 0.1 1.6 1 0 0 1 1 1 1 KR domain PP-binding PF00550.25 CCF53268.1 - 0.0014 18.9 0.1 0.0029 17.9 0.1 1.6 1 0 0 1 1 1 1 Phosphopantetheine attachment site Polysacc_synt_2 PF02719.15 CCF53268.1 - 0.028 13.5 0.0 0.048 12.8 0.0 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein HAD_2 PF13419.6 CCF53269.1 - 6.3e-07 29.7 0.0 0.00075 19.6 0.0 2.3 2 0 0 2 2 2 2 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 CCF53269.1 - 7.7e-07 29.1 0.0 1.4e-06 28.2 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.26 CCF53269.1 - 1.5e-05 25.4 0.0 4.1e-05 24.0 0.0 1.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Amastin PF07344.11 CCF53270.1 - 0.024 14.5 0.9 0.053 13.4 0.9 1.5 1 0 0 1 1 1 0 Amastin surface glycoprotein DHHC PF01529.20 CCF53271.1 - 9.5e-38 129.3 12.1 1.9e-37 128.4 9.0 2.2 2 0 0 2 2 2 1 DHHC palmitoyltransferase LIM PF00412.22 CCF53272.1 - 7e-20 71.0 17.8 1.2e-11 44.6 7.1 2.5 3 0 0 3 3 3 2 LIM domain zf-CSL PF05207.13 CCF53272.1 - 7.4 6.4 7.7 0.17 11.6 0.8 1.8 2 0 0 2 2 2 0 CSL zinc finger zf_UBZ PF18439.1 CCF53272.1 - 9.9 5.9 15.7 9.9 5.9 0.0 4.5 5 0 0 5 5 5 0 Ubiquitin-Binding Zinc Finger PMSR PF01625.21 CCF53273.1 - 4.1e-59 199.2 2.2 5.2e-59 198.8 2.2 1.1 1 0 0 1 1 1 1 Peptide methionine sulfoxide reductase Exo70 PF03081.15 CCF53274.1 - 7.8e-70 235.8 0.0 1.1e-69 235.3 0.0 1.2 1 0 0 1 1 1 1 Exo70 exocyst complex subunit SLT PF01464.20 CCF53275.1 - 8.5e-08 31.9 0.2 0.0014 18.3 0.0 2.7 3 0 0 3 3 3 2 Transglycosylase SLT domain Phage_lysozyme2 PF18013.1 CCF53275.1 - 0.042 13.9 0.2 0.14 12.2 0.0 1.8 2 0 0 2 2 2 0 Phage tail lysozyme Thiolase_N PF00108.23 CCF53276.1 - 3.5e-66 223.2 0.1 5.6e-66 222.6 0.1 1.3 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 CCF53276.1 - 9e-42 141.6 0.1 1.6e-41 140.8 0.1 1.4 1 0 0 1 1 1 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 CCF53276.1 - 0.0017 18.0 0.8 0.0041 16.7 0.8 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain zf-CCHC PF00098.23 CCF53277.1 - 0.0044 17.0 4.4 0.011 15.8 4.4 1.7 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_3 PF13917.6 CCF53277.1 - 0.038 14.0 0.3 0.093 12.7 0.3 1.6 1 0 0 1 1 1 0 Zinc knuckle Nucleos_tra2_C PF07662.13 CCF53278.1 - 1.6e-64 217.6 8.2 1.6e-64 217.6 8.2 2.6 2 1 0 2 2 2 1 Na+ dependent nucleoside transporter C-terminus Nucleos_tra2_N PF01773.20 CCF53278.1 - 4.6e-13 49.6 8.9 4.6e-13 49.6 8.9 3.2 3 0 0 3 3 3 1 Na+ dependent nucleoside transporter N-terminus Gate PF07670.14 CCF53278.1 - 0.27 11.5 21.2 0.017 15.4 11.3 3.6 2 1 1 3 3 3 0 Nucleoside recognition DPM2 PF07297.12 CCF53279.1 - 5e-27 94.0 0.3 5.8e-27 93.8 0.3 1.0 1 0 0 1 1 1 1 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) PIG-P PF08510.12 CCF53279.1 - 3.3e-05 23.8 0.2 3.8e-05 23.6 0.2 1.1 1 0 0 1 1 1 1 PIG-P DUF1361 PF07099.11 CCF53279.1 - 0.031 14.2 0.2 0.048 13.6 0.2 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1361) Man-6-P_recep PF02157.15 CCF53279.1 - 0.28 10.2 0.1 11 5.0 0.0 2.0 2 0 0 2 2 2 0 Mannose-6-phosphate receptor SHD1 PF03983.12 CCF53280.1 - 0.054 13.3 0.0 0.38 10.6 0.0 2.1 2 0 0 2 2 2 0 SLA1 homology domain 1, SHD1 Promethin PF16015.5 CCF53280.1 - 2.1 8.3 4.7 3.6 7.6 4.7 1.3 1 0 0 1 1 1 0 Promethin Peptidase_S24 PF00717.23 CCF53281.1 - 3.7e-05 23.6 0.0 0.00017 21.5 0.0 1.9 1 1 0 1 1 1 1 Peptidase S24-like Peptidase_S26 PF10502.9 CCF53281.1 - 0.0023 17.7 0.0 0.04 13.7 0.0 2.3 1 1 0 1 1 1 1 Signal peptidase, peptidase S26 DUF3425 PF11905.8 CCF53282.1 - 2.6e-11 43.6 6.2 3.4e-11 43.2 0.8 3.3 3 1 0 3 3 3 1 Domain of unknown function (DUF3425) bZIP_1 PF00170.21 CCF53282.1 - 1.3e-08 34.8 8.2 3e-08 33.6 6.9 2.2 1 1 1 2 2 2 1 bZIP transcription factor bZIP_2 PF07716.15 CCF53282.1 - 0.0057 16.7 4.9 0.0057 16.7 4.9 3.1 3 0 0 3 3 3 1 Basic region leucine zipper GvpL_GvpF PF06386.11 CCF53282.1 - 1.9 8.4 8.2 0.27 11.2 1.8 2.2 2 0 0 2 2 2 0 Gas vesicle synthesis protein GvpL/GvpF Ndc1_Nup PF09531.10 CCF53282.1 - 3.2 6.3 16.8 0.53 8.9 10.0 2.0 2 0 0 2 2 2 0 Nucleoporin protein Ndc1-Nup VHS PF00790.19 CCF53283.1 - 1.1e-26 93.4 0.0 2.6e-26 92.2 0.0 1.6 1 0 0 1 1 1 1 VHS domain GAT PF03127.14 CCF53283.1 - 2e-05 24.8 1.3 6.4e-05 23.2 1.2 2.0 2 0 0 2 2 2 1 GAT domain DUF573 PF04504.14 CCF53283.1 - 1 10.0 6.7 15 6.3 0.1 2.7 2 0 0 2 2 2 0 Protein of unknown function, DUF573 AAA_11 PF13086.6 CCF53284.1 - 0.45 10.3 10.3 1 9.1 10.3 1.5 1 0 0 1 1 1 0 AAA domain Raftlin PF15250.6 CCF53284.1 - 5.4 5.7 9.3 12 4.5 9.3 1.6 1 0 0 1 1 1 0 Raftlin Carn_acyltransf PF00755.20 CCF53285.1 - 2.9e-207 690.0 0.0 3.3e-207 689.8 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase DUF410 PF04190.13 CCF53286.1 - 0.13 12.0 0.1 0.2 11.4 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF410) zf-CHY PF05495.12 CCF53287.1 - 1.2e-12 48.1 16.3 2.2e-12 47.3 16.3 1.4 1 0 0 1 1 1 1 CHY zinc finger Cys_rich_KTR PF14205.6 CCF53287.1 - 0.00038 20.2 4.6 0.069 13.0 1.9 2.4 1 1 1 2 2 2 2 Cysteine-rich KTR zf-FPG_IleRS PF06827.14 CCF53287.1 - 0.024 14.5 0.9 0.024 14.5 0.9 2.5 4 0 0 4 4 2 0 Zinc finger found in FPG and IleRS HypA PF01155.19 CCF53287.1 - 0.035 14.1 1.2 0.035 14.1 1.2 2.1 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DUF3797 PF12677.7 CCF53287.1 - 0.089 12.7 3.0 1.1 9.3 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3797) Zn_Tnp_IS1595 PF12760.7 CCF53287.1 - 0.49 10.4 10.8 9.3 6.3 7.0 2.4 2 0 0 2 2 2 0 Transposase zinc-ribbon domain zinc_ribbon_2 PF13240.6 CCF53287.1 - 0.52 10.1 9.0 2.8 7.8 0.5 3.2 3 0 0 3 3 3 0 zinc-ribbon domain Zn-ribbon_8 PF09723.10 CCF53287.1 - 0.77 9.9 13.5 0.19 11.9 2.6 2.6 2 1 0 2 2 2 0 Zinc ribbon domain TF_Zn_Ribbon PF08271.12 CCF53287.1 - 0.79 9.3 6.5 11 5.7 2.0 2.9 2 1 0 2 2 2 0 TFIIB zinc-binding zinc_ribbon_4 PF13717.6 CCF53287.1 - 0.94 9.5 13.9 3.5 7.6 0.1 4.0 3 1 0 3 3 3 0 zinc-ribbon domain Elf1 PF05129.13 CCF53287.1 - 1.4 9.0 11.5 0.55 10.3 6.7 2.1 1 1 1 2 2 2 0 Transcription elongation factor Elf1 like DUF4379 PF14311.6 CCF53287.1 - 1.5 9.3 7.2 1 9.8 0.3 2.8 3 0 0 3 3 2 0 Probable Zinc-ribbon domain Evr1_Alr PF04777.13 CCF53287.1 - 2.3 8.7 10.1 66 4.1 10.1 2.7 1 1 0 1 1 1 0 Erv1 / Alr family DpnI PF06044.12 CCF53287.1 - 2.8 7.6 5.4 15 5.2 1.2 2.1 1 1 1 2 2 2 0 Dam-replacing family zf-H2C2_2 PF13465.6 CCF53287.1 - 4.1 8.0 10.2 6.1 7.5 0.3 3.2 3 0 0 3 3 3 0 Zinc-finger double domain zinc_ribbon_9 PF14369.6 CCF53287.1 - 5 7.5 12.0 0.58 10.5 2.9 2.9 2 1 1 3 3 3 0 zinc-ribbon Ofd1_CTDD PF10637.9 CCF53288.1 - 1.9e-92 309.3 0.0 2.4e-87 292.5 0.0 2.2 2 0 0 2 2 2 2 Oxoglutarate and iron-dependent oxygenase degradation C-term 2OG-FeII_Oxy_4 PF13661.6 CCF53288.1 - 1e-32 112.6 0.0 2.2e-32 111.5 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_3 PF13640.6 CCF53288.1 - 5.9e-16 59.1 0.0 1.5e-15 57.9 0.0 1.7 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DUF4315 PF14193.6 CCF53288.1 - 0.024 14.7 1.5 0.069 13.2 1.5 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4315) SCP2 PF02036.17 CCF53289.1 - 6.2e-17 62.0 0.0 9.2e-17 61.4 0.0 1.2 1 0 0 1 1 1 1 SCP-2 sterol transfer family Alkyl_sulf_C PF14864.6 CCF53289.1 - 0.077 13.3 0.0 0.1 12.9 0.0 1.3 1 0 0 1 1 1 0 Alkyl sulfatase C-terminal GPI-anchored PF10342.9 CCF53290.1 - 3.2e-11 43.8 0.0 3.2e-11 43.8 0.0 2.5 2 1 1 3 3 3 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family Macoilin PF09726.9 CCF53290.1 - 6.1 5.3 6.6 8 4.9 6.6 1.1 1 0 0 1 1 1 0 Macoilin family EHN PF06441.12 CCF53291.1 - 4.7e-28 97.7 0.1 1.1e-27 96.6 0.1 1.6 1 0 0 1 1 1 1 Epoxide hydrolase N terminus Abhydrolase_1 PF00561.20 CCF53291.1 - 1.4e-12 47.9 0.4 2.3e-12 47.1 0.4 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CCF53291.1 - 0.0031 18.1 1.3 0.008 16.8 1.0 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family PhzC-PhzF PF02567.16 CCF53292.1 - 1.2e-48 166.0 0.0 1.5e-48 165.7 0.0 1.1 1 0 0 1 1 1 1 Phenazine biosynthesis-like protein Pro_racemase PF05544.11 CCF53292.1 - 0.019 14.0 0.0 0.029 13.4 0.0 1.2 1 0 0 1 1 1 0 Proline racemase PhoD PF09423.10 CCF53293.1 - 2.1e-105 352.6 5.8 2.7e-105 352.2 5.8 1.1 1 0 0 1 1 1 1 PhoD-like phosphatase PhoD_N PF16655.5 CCF53293.1 - 2.3e-23 82.5 0.1 5.2e-23 81.4 0.1 1.7 1 0 0 1 1 1 1 PhoD-like phosphatase, N-terminal domain Pur_ac_phosph_N PF16656.5 CCF53293.1 - 3.9e-07 30.5 1.3 1.9e-06 28.3 1.3 2.2 1 0 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain DUF5012 PF16404.5 CCF53293.1 - 0.0092 16.1 3.2 0.012 15.8 0.3 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF5012) Phytase-like PF13449.6 CCF53294.1 - 9.6e-30 104.5 0.2 1.6e-29 103.8 0.2 1.4 1 1 0 1 1 1 1 Esterase-like activity of phytase DUF2719 PF10891.8 CCF53294.1 - 0.1 12.5 0.4 0.18 11.7 0.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2719) ADH_N PF08240.12 CCF53295.1 - 4.3e-23 81.3 6.3 4.3e-23 81.3 6.3 1.5 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CCF53295.1 - 3.8e-18 65.7 0.1 2.1e-17 63.3 0.0 2.0 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CCF53295.1 - 5.7e-07 30.7 0.0 1e-06 29.8 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 CCF53295.1 - 2.8e-05 23.6 0.0 0.00042 19.7 0.0 2.1 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.21 CCF53295.1 - 0.0028 17.0 0.0 0.0084 15.4 0.0 1.7 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain Oxidored_nitro PF00148.19 CCF53295.1 - 0.009 14.8 0.0 0.012 14.3 0.0 1.1 1 0 0 1 1 1 1 Nitrogenase component 1 type Oxidoreductase OSR1_C PF12202.8 CCF53295.1 - 0.054 13.7 0.8 5.9 7.2 0.1 2.4 2 0 0 2 2 2 0 Oxidative-stress-responsive kinase 1 C-terminal domain PTH2 PF01981.16 CCF53296.1 - 9.3e-44 148.5 0.5 1.2e-43 148.1 0.5 1.1 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 Sua5_yciO_yrdC PF01300.18 CCF53296.1 - 0.0063 16.0 0.0 1.5 8.3 0.0 2.1 1 1 1 2 2 2 2 Telomere recombination TRM13 PF05206.14 CCF53296.1 - 0.092 12.3 0.2 0.14 11.7 0.2 1.3 1 1 0 1 1 1 0 Methyltransferase TRM13 FGGY_C PF02782.16 CCF53297.1 - 7.6e-47 159.6 0.0 1.2e-46 159.0 0.0 1.3 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.21 CCF53297.1 - 2.4e-17 63.4 0.3 1.3e-09 37.9 0.0 2.8 2 1 0 2 2 2 2 FGGY family of carbohydrate kinases, N-terminal domain BcrAD_BadFG PF01869.20 CCF53297.1 - 3.2e-05 23.6 0.2 0.0014 18.2 0.1 2.2 2 0 0 2 2 2 2 BadF/BadG/BcrA/BcrD ATPase family AnmK PF03702.14 CCF53297.1 - 0.0099 15.0 0.0 0.018 14.1 0.0 1.3 1 0 0 1 1 1 1 Anhydro-N-acetylmuramic acid kinase Arginase PF00491.21 CCF53298.1 - 1e-84 284.4 0.0 1.4e-84 283.9 0.0 1.2 1 0 0 1 1 1 1 Arginase family GIY-YIG PF01541.24 CCF53299.1 - 3.7e-10 39.9 0.0 1.1e-09 38.4 0.0 1.9 1 0 0 1 1 1 1 GIY-YIG catalytic domain zf-rbx1 PF12678.7 CCF53299.1 - 0.02 15.2 0.6 0.41 11.0 0.6 2.6 1 1 0 1 1 1 0 RING-H2 zinc finger domain FANCL_C PF11793.8 CCF53299.1 - 0.061 13.5 0.2 0.22 11.7 0.0 2.0 2 0 0 2 2 2 0 FANCL C-terminal domain zf-HC5HC2H PF13771.6 CCF53299.1 - 0.38 11.0 2.0 2.8 8.3 2.0 2.3 1 1 0 1 1 1 0 PHD-like zinc-binding domain zf-RING_2 PF13639.6 CCF53299.1 - 6.9 7.1 9.4 4.6 7.7 0.0 3.3 3 1 1 4 4 4 0 Ring finger domain PAXIP1_C PF15364.6 CCF53299.1 - 8.8 6.6 9.2 1.6 9.0 0.1 2.6 2 1 0 2 2 2 0 PAXIP1-associated-protein-1 C term PTIP binding protein Mito_carr PF00153.27 CCF53300.1 - 1.7e-31 108.0 8.2 3.7e-12 46.0 0.3 5.2 4 1 0 4 4 4 3 Mitochondrial carrier protein Serine_protease PF18405.1 CCF53300.1 - 0.015 14.5 1.6 0.22 10.7 0.1 2.3 2 0 0 2 2 2 0 Gammaproteobacterial serine protease SBF PF01758.16 CCF53301.1 - 1.5e-47 161.8 12.9 1.5e-47 161.8 12.9 2.0 2 0 0 2 2 2 1 Sodium Bile acid symporter family Bacillus_PapR PF05968.11 CCF53301.1 - 0.59 10.0 2.3 1.3 8.9 0.2 2.6 2 0 0 2 2 2 0 Bacillus PapR protein p450 PF00067.22 CCF53302.1 - 1.3e-54 185.7 0.0 2.4e-35 122.2 0.0 2.1 2 0 0 2 2 2 2 Cytochrome P450 Aa_trans PF01490.18 CCF53303.1 - 0.0022 16.8 0.2 0.0026 16.5 0.2 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Abhydrolase_9_N PF15420.6 CCF53303.1 - 0.11 12.5 0.0 0.12 12.4 0.0 1.0 1 0 0 1 1 1 0 Alpha/beta-hydrolase family N-terminus DRMBL PF07522.14 CCF53304.1 - 1.3e-27 96.2 0.0 2.4e-27 95.3 0.0 1.5 1 0 0 1 1 1 1 DNA repair metallo-beta-lactamase Lactamase_B_2 PF12706.7 CCF53304.1 - 0.01 15.4 0.0 0.021 14.3 0.0 1.5 1 0 0 1 1 1 0 Beta-lactamase superfamily domain Lactamase_B PF00753.27 CCF53304.1 - 0.059 13.4 0.3 0.13 12.3 0.3 1.5 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily PI-PLC-X PF00388.19 CCF53305.1 - 2.5e-46 156.9 0.0 3.7e-46 156.3 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 CCF53305.1 - 6.8e-38 129.6 0.0 1.2e-37 128.8 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain C2 PF00168.30 CCF53305.1 - 9.9e-06 25.8 0.0 3.5e-05 24.0 0.0 1.9 2 0 0 2 2 2 1 C2 domain SET PF00856.28 CCF53307.1 - 7.2e-08 33.0 0.0 9.4e-07 29.4 0.0 2.8 3 1 0 3 3 3 1 SET domain DUF2605 PF10792.9 CCF53307.1 - 0.029 14.3 0.1 5 7.1 0.0 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2605) Hemerythrin PF01814.23 CCF53307.1 - 0.05 14.2 0.7 0.13 12.9 0.7 1.7 1 0 0 1 1 1 0 Hemerythrin HHE cation binding domain TPR_2 PF07719.17 CCF53307.1 - 0.061 13.5 0.2 0.061 13.5 0.2 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat Sugar_tr PF00083.24 CCF53308.1 - 5.3e-30 104.7 26.1 8e-16 57.9 2.0 2.1 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 CCF53308.1 - 2.1e-21 76.2 48.0 2.7e-13 49.6 26.7 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Oxidored_FMN PF00724.20 CCF53309.1 - 1.9e-37 129.3 0.0 8.3e-36 123.9 0.0 2.7 2 1 0 2 2 2 1 NADH:flavin oxidoreductase / NADH oxidase family GST_N_3 PF13417.6 CCF53310.1 - 1.4e-20 73.5 0.0 2.4e-20 72.7 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 CCF53310.1 - 4.5e-19 68.5 0.0 7.6e-19 67.8 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 CCF53310.1 - 3.7e-14 52.8 0.0 6.4e-14 52.1 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 CCF53310.1 - 1.6e-05 24.8 0.0 4.5e-05 23.4 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain Glutaredoxin PF00462.24 CCF53310.1 - 0.041 14.1 0.0 0.08 13.2 0.0 1.4 1 0 0 1 1 1 0 Glutaredoxin GST_C_5 PF16865.5 CCF53310.1 - 0.057 14.0 0.0 0.1 13.2 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Peptidase_S9 PF00326.21 CCF53311.1 - 0.00026 20.5 0.0 0.00048 19.7 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Lactamase_B_2 PF12706.7 CCF53312.1 - 4.3e-28 98.2 0.0 1.3e-27 96.6 0.0 1.9 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Methyltransf_31 PF13847.6 CCF53312.1 - 1.4e-14 54.1 0.0 2.9e-14 53.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF53312.1 - 3.2e-07 31.0 0.0 6.9e-07 29.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Lactamase_B_3 PF13483.6 CCF53312.1 - 3.1e-06 27.2 0.1 2.3e-05 24.3 0.1 2.2 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Methyltransf_25 PF13649.6 CCF53312.1 - 5.1e-05 23.9 0.0 0.00024 21.8 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCF53312.1 - 0.00095 19.0 0.0 0.0044 16.9 0.0 2.1 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_32 PF13679.6 CCF53312.1 - 0.0011 19.0 0.0 0.0017 18.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF53312.1 - 0.0012 19.4 0.0 0.011 16.4 0.0 2.4 2 1 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 CCF53312.1 - 0.043 13.4 0.0 0.23 11.0 0.0 1.9 1 1 1 2 2 2 0 Methyltransferase small domain UPF0052 PF01933.18 CCF53313.1 - 7.3e-43 146.9 0.0 1.8e-42 145.6 0.0 1.6 1 1 0 1 1 1 1 Uncharacterised protein family UPF0052 GalP_UDP_transf PF01087.22 CCF53314.1 - 1.3e-68 231.1 0.4 2.2e-68 230.3 0.4 1.3 1 0 0 1 1 1 1 Galactose-1-phosphate uridyl transferase, N-terminal domain GalP_UDP_tr_C PF02744.17 CCF53314.1 - 1.5e-47 161.4 0.0 2.8e-47 160.5 0.0 1.4 1 0 0 1 1 1 1 Galactose-1-phosphate uridyl transferase, C-terminal domain DUF4921 PF16268.5 CCF53314.1 - 1e-05 24.5 0.1 0.014 14.2 0.0 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF4921) DUF2781 PF10914.8 CCF53315.1 - 2.6e-35 122.0 3.0 3.1e-35 121.8 3.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2781) Zn_clus PF00172.18 CCF53316.1 - 7.1e-05 22.8 13.7 0.00015 21.8 13.7 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PRIMA1 PF16101.5 CCF53317.1 - 0.013 15.5 0.1 0.014 15.4 0.1 1.1 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 Exo_endo_phos PF03372.23 CCF53319.1 - 0.0014 18.2 0.0 0.0073 15.8 0.0 2.0 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DUF1682 PF07946.14 CCF53320.1 - 5.6e-88 295.3 0.0 6.4e-88 295.1 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1682) RR_TM4-6 PF06459.12 CCF53320.1 - 2 8.2 10.1 1.3 8.8 8.1 1.6 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 4F5 PF04419.14 CCF53321.1 - 4.3e-09 37.1 9.7 4.3e-09 37.1 9.7 2.2 2 0 0 2 2 2 2 4F5 protein family adh_short PF00106.25 CCF53322.1 - 3e-26 92.1 0.0 5.3e-24 84.7 0.0 2.2 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CCF53322.1 - 8.1e-14 51.7 0.0 7.1e-13 48.6 0.0 2.0 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF53322.1 - 2.4e-08 34.1 0.1 4.3e-08 33.3 0.1 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CCF53322.1 - 0.00052 19.5 0.1 0.00076 19.0 0.1 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Pyr_redox_3 PF13738.6 CCF53322.1 - 0.17 11.1 0.1 0.35 10.1 0.0 1.5 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Pmp3 PF01679.17 CCF53323.1 - 6.6e-12 45.4 5.8 9.6e-12 44.9 5.8 1.2 1 0 0 1 1 1 1 Proteolipid membrane potential modulator Thioredoxin_4 PF13462.6 CCF53324.1 - 5.9e-06 26.5 0.0 0.0003 21.0 0.0 2.2 2 1 0 2 2 2 2 Thioredoxin DSBA PF01323.20 CCF53324.1 - 0.12 12.1 0.0 2 8.2 0.0 2.4 3 0 0 3 3 3 0 DSBA-like thioredoxin domain MFS_1 PF07690.16 CCF53325.1 - 2.2e-40 138.7 47.8 2.4e-39 135.3 43.9 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF53325.1 - 5.8e-16 58.4 10.9 5.8e-16 58.4 10.9 2.3 2 0 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.13 CCF53325.1 - 6e-11 41.5 9.6 6e-11 41.5 9.6 2.3 2 1 1 3 3 3 1 Fungal trichothecene efflux pump (TRI12) DUF2619 PF10942.8 CCF53325.1 - 0.034 14.2 0.2 0.23 11.5 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2619) Mit_proteolip PF08039.11 CCF53325.1 - 0.23 11.9 1.9 1.9 9.0 0.1 2.4 2 0 0 2 2 2 0 Mitochondrial proteolipid ADH_zinc_N_2 PF13602.6 CCF53326.1 - 3.9e-18 66.8 0.2 3.9e-17 63.5 0.1 2.3 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 CCF53326.1 - 6.3e-18 65.0 0.5 1.2e-17 64.1 0.5 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CCF53326.1 - 1.1e-11 44.5 0.0 3.1e-11 43.1 0.0 1.8 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain DAGK_cat PF00781.24 CCF53326.1 - 0.016 14.9 0.1 0.027 14.1 0.1 1.4 1 0 0 1 1 1 0 Diacylglycerol kinase catalytic domain PHBC_N PF12551.8 CCF53326.1 - 0.047 13.5 0.3 0.1 12.4 0.3 1.5 1 0 0 1 1 1 0 Poly-beta-hydroxybutyrate polymerase N terminal ADH_N_2 PF16884.5 CCF53326.1 - 0.048 13.6 0.0 0.14 12.0 0.0 1.8 1 1 0 1 1 1 0 N-terminal domain of oxidoreductase Peptidase_S10 PF00450.22 CCF53328.1 - 9.6e-116 387.6 0.4 1.3e-115 387.2 0.4 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase Peptidase_S10 PF00450.22 CCF53329.1 - 6.8e-77 259.6 0.1 9.4e-77 259.2 0.1 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase RVT_2 PF07727.14 CCF53331.1 - 6.6e-28 98.0 0.0 8.1e-24 84.6 0.0 2.4 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) gag_pre-integrs PF13976.6 CCF53332.1 - 1.8e-06 27.7 0.8 1.8e-06 27.7 0.8 1.9 2 0 0 2 2 2 1 GAG-pre-integrase domain rve PF00665.26 CCF53332.1 - 4.9e-06 26.7 0.2 1.6e-05 25.1 0.1 2.0 2 0 0 2 2 2 1 Integrase core domain zf-CCHC PF00098.23 CCF53332.1 - 0.098 12.8 3.4 0.3 11.3 3.4 1.9 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_6 PF15288.6 CCF53332.1 - 1.7 8.6 5.0 5.5 6.9 5.0 1.9 1 0 0 1 1 1 0 Zinc knuckle Sugar_tr PF00083.24 CCF53333.1 - 2.1e-63 214.8 11.7 1.1e-44 153.1 0.8 2.0 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 CCF53333.1 - 1.3e-17 63.8 23.1 5e-09 35.5 4.4 2.3 2 1 0 2 2 2 2 Major Facilitator Superfamily GTP_EFTU PF00009.27 CCF53334.1 - 1.1e-47 162.1 0.0 1.7e-47 161.5 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain LepA_C PF06421.12 CCF53334.1 - 9.6e-38 128.6 0.9 1.7e-37 127.9 0.9 1.4 1 0 0 1 1 1 1 GTP-binding protein LepA C-terminus EFG_C PF00679.24 CCF53334.1 - 1.5e-17 63.4 0.0 5.2e-17 61.6 0.0 1.9 2 0 0 2 2 2 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 CCF53334.1 - 1.4e-07 31.8 0.1 2.5e-07 31.0 0.1 1.5 1 0 0 1 1 1 1 Elongation factor Tu domain 2 RF3_C PF16658.5 CCF53334.1 - 0.0016 18.3 0.0 0.0032 17.3 0.0 1.5 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain EFG_II PF14492.6 CCF53334.1 - 0.002 18.2 0.0 0.005 16.9 0.0 1.7 1 0 0 1 1 1 1 Elongation Factor G, domain II ICL PF00463.21 CCF53335.1 - 5e-190 632.5 0.6 6.1e-190 632.2 0.6 1.0 1 0 0 1 1 1 1 Isocitrate lyase family PEP_mutase PF13714.6 CCF53335.1 - 1e-09 38.2 0.0 2.7e-09 36.8 0.0 1.7 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase DUF2458 PF10454.9 CCF53335.1 - 0.0051 16.5 0.3 0.013 15.1 0.3 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2458) SNCAIP_SNCA_bd PF16700.5 CCF53335.1 - 0.035 13.8 0.0 4.5 7.1 0.0 3.1 4 0 0 4 4 4 0 Synphilin-1 alpha-Synuclein-binding domain Methyltransf_16 PF10294.9 CCF53336.1 - 3e-14 53.1 0.1 7.4e-14 51.9 0.1 1.6 1 1 0 1 1 1 1 Lysine methyltransferase MTS PF05175.14 CCF53336.1 - 0.007 15.9 0.0 0.013 15.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Pet191_N PF10203.9 CCF53339.1 - 5.8e-26 90.6 4.5 6.7e-26 90.4 4.5 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein PET191 Cmc1 PF08583.10 CCF53339.1 - 0.14 12.2 2.0 9 6.4 0.1 2.5 1 1 2 3 3 3 0 Cytochrome c oxidase biogenesis protein Cmc1 like Abhydrolase_6 PF12697.7 CCF53340.1 - 0.0072 17.0 0.1 0.019 15.6 0.1 1.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family Helveticin_J PF17312.2 CCF53340.1 - 0.072 12.2 0.0 0.11 11.6 0.0 1.2 1 0 0 1 1 1 0 Bacteriocin helveticin-J RVT_2 PF07727.14 CCF53341.1 - 2.1e-36 125.8 0.2 2.3e-36 125.7 0.2 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.27 CCF53341.1 - 0.032 13.7 0.2 0.13 11.8 0.2 1.9 1 1 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) APC_r PF05923.12 CCF53341.1 - 0.17 11.7 0.0 0.4 10.5 0.0 1.6 1 0 0 1 1 1 0 APC repeat HTH_Bact PF18768.1 CCF53342.1 - 0.059 13.0 0.0 0.11 12.1 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix bacterial domain Amidohydro_3 PF07969.11 CCF53343.1 - 0.013 15.0 0.0 0.016 14.7 0.0 1.1 1 0 0 1 1 1 0 Amidohydrolase family DUF5330 PF17264.2 CCF53343.1 - 0.014 15.4 0.1 0.03 14.3 0.1 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5330) gag_pre-integrs PF13976.6 CCF53343.1 - 0.035 14.0 0.6 0.065 13.1 0.6 1.5 1 0 0 1 1 1 0 GAG-pre-integrase domain rve PF00665.26 CCF53343.1 - 0.047 13.9 0.1 0.12 12.6 0.1 1.6 1 0 0 1 1 1 0 Integrase core domain Integrase_H2C2 PF17921.1 CCF53343.1 - 1.3 9.2 4.0 7.5 6.8 0.1 3.2 3 1 0 3 3 3 0 Integrase zinc binding domain FAP206 PF12018.8 CCF53344.1 - 0.0012 18.5 0.0 0.0015 18.1 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function R3H-assoc PF13902.6 CCF53344.1 - 0.21 12.0 1.8 1.7 9.0 0.0 2.4 2 1 0 2 2 2 0 R3H-associated N-terminal domain BTB PF00651.31 CCF53345.1 - 3.3e-10 40.2 0.1 1.6e-08 34.8 0.1 2.9 1 1 0 1 1 1 1 BTB/POZ domain Glyco_hydro_16 PF00722.21 CCF53346.1 - 0.00024 20.6 0.0 0.00042 19.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 MFS_1 PF07690.16 CCF53347.1 - 6.8e-33 114.1 34.6 6.8e-33 114.1 34.6 1.8 1 1 1 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 CCF53347.1 - 3.5e-06 25.8 1.5 5.3e-06 25.1 1.5 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 CCF53348.1 - 6.8e-62 209.8 20.6 4.4e-60 203.8 20.6 2.0 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF53348.1 - 1.9e-12 46.8 42.2 1.9e-12 46.8 42.2 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily BLM10_mid PF16507.5 CCF53349.1 - 6.1e-180 599.3 0.0 1.1e-179 598.5 0.0 1.4 1 0 0 1 1 1 1 Proteasome-substrate-size regulator, mid region DUF3437 PF11919.8 CCF53349.1 - 9.6e-26 89.5 0.1 2.6e-24 84.9 0.0 3.4 3 0 0 3 3 3 1 Domain of unknown function (DUF3437) HEAT PF02985.22 CCF53349.1 - 0.00019 21.4 0.1 0.0027 17.8 0.0 3.2 2 0 0 2 2 2 1 HEAT repeat BLM10_N PF16547.5 CCF53349.1 - 0.00055 20.2 0.2 0.002 18.4 0.1 2.0 2 0 0 2 2 2 1 Proteasome-substrate-size regulator, N-terminal Arm PF00514.23 CCF53349.1 - 0.002 18.1 0.2 0.014 15.5 0.0 2.6 2 0 0 2 2 2 1 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 CCF53349.1 - 0.0041 17.5 0.3 0.036 14.4 0.0 2.8 3 0 0 3 3 3 1 HEAT repeats HEAT_EZ PF13513.6 CCF53349.1 - 0.0063 17.0 0.0 0.12 12.9 0.0 2.8 2 0 0 2 2 2 1 HEAT-like repeat Vac14_Fab1_bd PF12755.7 CCF53349.1 - 0.058 14.0 0.0 0.34 11.5 0.0 2.4 1 0 0 1 1 1 0 Vacuolar 14 Fab1-binding region DCB PF16213.5 CCF53349.1 - 0.078 12.6 0.7 1.3 8.6 0.1 2.7 2 0 0 2 2 2 0 Dimerisation and cyclophilin-binding domain of Mon2 Cnd1 PF12717.7 CCF53349.1 - 0.095 12.7 0.0 2.8 8.0 0.0 3.1 3 0 0 3 3 3 0 non-SMC mitotic condensation complex subunit 1 Ras PF00071.22 CCF53350.1 - 7e-62 207.8 0.1 8.4e-62 207.5 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CCF53350.1 - 8.2e-34 116.4 0.1 1.3e-33 115.8 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CCF53350.1 - 2e-12 46.9 0.0 2.8e-12 46.4 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 CCF53350.1 - 5.2e-06 26.5 0.0 8.9e-06 25.8 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 CCF53350.1 - 0.00017 21.2 0.1 0.001 18.6 0.1 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 CCF53350.1 - 0.0014 18.5 0.1 0.15 12.0 0.0 2.1 2 0 0 2 2 2 1 RsgA GTPase AAA_22 PF13401.6 CCF53350.1 - 0.0033 17.7 0.1 0.041 14.2 0.0 2.3 2 1 0 2 2 2 1 AAA domain SRPRB PF09439.10 CCF53350.1 - 0.0033 16.9 0.0 0.0068 15.9 0.0 1.4 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_16 PF13191.6 CCF53350.1 - 0.006 17.0 0.1 0.01 16.3 0.1 1.4 1 1 0 1 1 1 1 AAA ATPase domain Gtr1_RagA PF04670.12 CCF53350.1 - 0.011 15.1 0.1 0.023 14.0 0.1 1.6 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region PduV-EutP PF10662.9 CCF53350.1 - 0.018 14.8 0.0 0.067 12.9 0.0 1.9 2 1 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation ABC_tran PF00005.27 CCF53350.1 - 0.033 14.7 0.2 0.044 14.3 0.2 1.6 1 1 0 1 1 1 0 ABC transporter AAA_7 PF12775.7 CCF53350.1 - 0.038 13.5 0.1 0.085 12.4 0.0 1.5 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_28 PF13521.6 CCF53350.1 - 0.048 13.9 0.2 0.3 11.3 0.1 2.1 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 CCF53350.1 - 0.051 13.3 0.0 0.12 12.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_21 PF13304.6 CCF53350.1 - 0.066 13.0 0.1 0.11 12.3 0.1 1.4 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system TniB PF05621.11 CCF53350.1 - 0.076 12.4 0.0 0.21 11.0 0.0 1.7 2 0 0 2 2 2 0 Bacterial TniB protein MCM PF00493.23 CCF53350.1 - 0.079 12.1 0.0 0.14 11.3 0.0 1.4 1 0 0 1 1 1 0 MCM P-loop domain AAA_5 PF07728.14 CCF53350.1 - 0.1 12.6 0.0 0.21 11.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AEP1 PF17049.5 CCF53350.1 - 0.14 11.2 0.0 0.2 10.7 0.0 1.1 1 0 0 1 1 1 0 ATPase expression protein 1 LIP PF03583.14 CCF53351.1 - 3.2e-66 223.6 0.0 4.5e-66 223.1 0.0 1.1 1 0 0 1 1 1 1 Secretory lipase Peptidase_S9 PF00326.21 CCF53351.1 - 0.0032 17.0 0.0 0.55 9.7 0.0 2.4 2 0 0 2 2 2 2 Prolyl oligopeptidase family RVT_1 PF00078.27 CCF53353.1 - 1.2e-05 24.9 0.0 2e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 CCF53353.1 - 0.0011 19.2 0.0 0.0037 17.5 0.0 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 CCF53353.1 - 0.0017 18.4 0.0 0.027 14.5 0.0 2.5 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase DUF5427 PF10310.9 CCF53355.1 - 4.2e-43 148.0 8.1 8e-41 140.5 3.3 2.4 1 1 1 2 2 2 2 Family of unknown function (DUF5427) DUF883 PF05957.13 CCF53355.1 - 0.29 11.7 8.2 8.9 7.0 0.1 2.9 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF883) Med3 PF11593.8 CCF53355.1 - 3.5 6.7 9.8 5.2 6.2 9.8 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Inositol_P PF00459.25 CCF53356.1 - 7.7e-56 189.6 0.3 5e-54 183.7 0.3 2.0 1 1 0 1 1 1 1 Inositol monophosphatase family zf-C2H2_4 PF13894.6 CCF53357.1 - 1.9e-07 31.3 6.3 0.0037 18.0 0.5 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.26 CCF53357.1 - 5e-07 29.8 6.5 0.0044 17.4 0.6 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_6 PF13912.6 CCF53357.1 - 0.00032 20.6 0.1 0.0009 19.2 0.1 1.8 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 CCF53357.1 - 0.0041 17.4 7.0 0.14 12.5 0.5 2.7 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-LYAR PF08790.11 CCF53357.1 - 0.074 13.0 3.3 3.6 7.6 0.6 2.6 2 0 0 2 2 2 0 LYAR-type C2HC zinc finger zf-C2H2_3rep PF18868.1 CCF53357.1 - 1.2 9.8 3.9 27 5.4 0.1 2.7 2 1 0 3 3 3 0 Zinc finger C2H2-type, 3 repeats zf-H2C2_2 PF13465.6 CCF53357.1 - 2.1 8.9 13.5 1.7 9.2 0.1 3.5 4 0 0 4 4 4 0 Zinc-finger double domain Mito_carr PF00153.27 CCF53359.1 - 4.2e-57 190.1 2.0 4.6e-21 74.5 0.2 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF1387 PF07139.11 CCF53361.1 - 2 8.1 17.7 2.9 7.6 17.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) HNF-1_N PF04814.13 CCF53361.1 - 4.4 7.9 0.0 4.4 7.9 0.0 2.4 2 1 0 2 2 2 0 Hepatocyte nuclear factor 1 (HNF-1), N terminus Vps39_2 PF10367.9 CCF53362.1 - 3e-12 47.0 0.1 1e-11 45.2 0.1 2.0 1 0 0 1 1 1 1 Vacuolar sorting protein 39 domain 2 Vps39_1 PF10366.9 CCF53362.1 - 0.0044 17.3 0.1 0.017 15.4 0.0 2.1 2 0 0 2 2 2 1 Vacuolar sorting protein 39 domain 1 CNH PF00780.22 CCF53362.1 - 0.0073 16.0 0.0 0.026 14.1 0.0 1.9 1 1 0 1 1 1 1 CNH domain AAA PF00004.29 CCF53363.1 - 9.4e-41 139.3 0.0 1.7e-40 138.5 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.10 CCF53363.1 - 1e-28 99.1 0.4 4e-28 97.2 0.0 2.3 3 0 0 3 3 1 1 Vps4 C terminal oligomerisation domain MIT PF04212.18 CCF53363.1 - 1.7e-24 85.6 7.8 6.3e-24 83.8 7.8 2.1 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain AAA_lid_3 PF17862.1 CCF53363.1 - 3.1e-09 36.5 0.0 6.1e-08 32.3 0.0 2.7 2 0 0 2 2 2 1 AAA+ lid domain AAA_22 PF13401.6 CCF53363.1 - 3e-05 24.3 0.5 0.086 13.1 0.0 2.8 2 1 1 3 3 2 2 AAA domain AAA_16 PF13191.6 CCF53363.1 - 3e-05 24.5 0.4 0.0065 16.9 0.0 2.9 3 1 1 4 4 3 1 AAA ATPase domain TIP49 PF06068.13 CCF53363.1 - 6.3e-05 22.3 0.4 0.00014 21.2 0.0 1.7 2 0 0 2 2 2 1 TIP49 P-loop domain RuvB_N PF05496.12 CCF53363.1 - 6.7e-05 22.7 0.0 0.00012 21.8 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain RNA_helicase PF00910.22 CCF53363.1 - 0.00013 22.3 0.1 0.018 15.4 0.0 3.3 3 0 0 3 3 3 1 RNA helicase IstB_IS21 PF01695.17 CCF53363.1 - 0.00015 21.5 0.0 0.00039 20.2 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_5 PF07728.14 CCF53363.1 - 0.0002 21.4 0.0 0.00062 19.8 0.0 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 CCF53363.1 - 0.00032 20.9 0.1 0.0011 19.2 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_14 PF13173.6 CCF53363.1 - 0.00058 19.9 1.1 0.0025 17.8 0.0 2.5 3 0 0 3 3 3 1 AAA domain DUF815 PF05673.13 CCF53363.1 - 0.0017 17.5 0.0 0.004 16.4 0.0 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF815) AAA_2 PF07724.14 CCF53363.1 - 0.0023 18.1 0.1 0.012 15.7 0.0 2.2 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_17 PF13207.6 CCF53363.1 - 0.0081 16.6 0.1 0.032 14.7 0.0 2.1 2 0 0 2 2 2 1 AAA domain Mg_chelatase PF01078.21 CCF53363.1 - 0.0089 15.4 0.0 0.026 13.9 0.0 1.7 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI ATPase PF06745.13 CCF53363.1 - 0.013 14.8 0.1 5.4 6.3 0.0 2.3 1 1 1 2 2 2 0 KaiC AAA_18 PF13238.6 CCF53363.1 - 0.014 16.0 0.3 0.058 13.9 0.0 2.3 2 1 0 2 2 2 0 AAA domain AAA_25 PF13481.6 CCF53363.1 - 0.018 14.6 0.2 0.77 9.3 0.1 2.3 1 1 1 2 2 2 0 AAA domain AAA_24 PF13479.6 CCF53363.1 - 0.024 14.4 0.2 0.13 12.0 0.0 2.3 2 0 0 2 2 2 0 AAA domain Sigma54_activat PF00158.26 CCF53363.1 - 0.056 13.1 0.0 0.47 10.1 0.0 2.2 1 1 0 1 1 1 0 Sigma-54 interaction domain AFG1_ATPase PF03969.16 CCF53363.1 - 0.07 12.0 0.1 1.7 7.5 0.0 2.4 2 0 0 2 2 2 0 AFG1-like ATPase PhoH PF02562.16 CCF53363.1 - 0.11 12.0 0.1 0.3 10.5 0.1 1.7 1 0 0 1 1 1 0 PhoH-like protein NACHT PF05729.12 CCF53363.1 - 0.11 12.4 0.0 0.8 9.6 0.0 2.3 2 1 1 3 3 3 0 NACHT domain DUF4407 PF14362.6 CCF53363.1 - 5.2 6.3 5.4 0.83 8.9 1.1 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Xpo1 PF08389.12 CCF53364.1 - 9.8e-23 80.9 0.0 1.7e-21 76.9 0.0 2.9 2 0 0 2 2 2 1 Exportin 1-like protein IBN_N PF03810.19 CCF53364.1 - 8e-07 28.9 0.3 4.1e-06 26.6 0.5 2.2 2 0 0 2 2 2 1 Importin-beta N-terminal domain Ten_N PF06484.12 CCF53364.1 - 0.12 12.2 1.5 0.3 10.9 1.6 1.5 2 0 0 2 2 2 0 Teneurin Intracellular Region ParcG PF10274.9 CCF53364.1 - 0.13 12.4 0.0 22 5.1 0.0 3.3 3 1 0 4 4 4 0 Parkin co-regulated protein Ysc84 PF04366.12 CCF53365.1 - 1.9e-38 131.1 0.9 3.8e-38 130.1 0.9 1.5 1 0 0 1 1 1 1 Las17-binding protein actin regulator SH3_1 PF00018.28 CCF53365.1 - 2.4e-11 43.0 0.0 6.9e-11 41.6 0.0 1.9 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 CCF53365.1 - 1.5e-08 34.4 0.0 3e-08 33.4 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 CCF53365.1 - 3.6e-08 33.0 0.0 9e-08 31.7 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain CoA_binding PF02629.19 CCF53366.1 - 8.7e-28 96.9 0.1 1.9e-27 95.8 0.1 1.6 1 0 0 1 1 1 1 CoA binding domain Ligase_CoA PF00549.19 CCF53366.1 - 2.8e-21 75.9 0.1 5.2e-21 75.1 0.1 1.4 1 0 0 1 1 1 1 CoA-ligase Succ_CoA_lig PF13607.6 CCF53366.1 - 5.3e-07 29.5 0.0 1.3e-06 28.2 0.0 1.7 2 0 0 2 2 2 1 Succinyl-CoA ligase like flavodoxin domain CoA_binding_2 PF13380.6 CCF53366.1 - 0.00035 21.0 0.0 0.00096 19.6 0.0 1.7 2 0 0 2 2 2 1 CoA binding domain Utp12 PF04003.12 CCF53367.1 - 5.9e-24 84.4 0.5 1.2e-23 83.5 0.5 1.5 1 0 0 1 1 1 1 Dip2/Utp12 Family WD40 PF00400.32 CCF53367.1 - 0.0094 16.8 3.8 0.01 16.7 0.1 3.2 2 1 0 2 2 2 1 WD domain, G-beta repeat Pkinase PF00069.25 CCF53368.1 - 7.9e-74 248.3 0.0 9.1e-74 248.1 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF53368.1 - 5.8e-35 120.8 0.0 7.2e-35 120.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 CCF53368.1 - 0.00017 20.7 0.0 0.0012 17.9 0.0 1.9 1 1 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 CCF53368.1 - 0.042 13.8 0.0 0.12 12.2 0.0 1.6 1 1 0 1 1 1 0 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 CCF53368.1 - 0.072 12.1 0.0 0.13 11.3 0.0 1.4 1 1 0 1 1 1 0 Seadornavirus VP7 Kinase-like PF14531.6 CCF53368.1 - 0.12 11.7 0.0 0.18 11.1 0.0 1.4 1 0 0 1 1 1 0 Kinase-like Kdo PF06293.14 CCF53368.1 - 0.24 10.7 0.4 0.71 9.2 0.4 1.7 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Cut8 PF08559.10 CCF53370.1 - 7.6e-15 55.2 1.2 3.1e-13 49.9 0.0 2.6 3 0 0 3 3 3 2 Cut8, nuclear proteasome tether protein PBP1_TM PF14812.6 CCF53370.1 - 2.4 8.6 8.2 0.5 10.8 4.2 1.9 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal MCM PF00493.23 CCF53373.1 - 1.4e-97 325.2 0.2 2.3e-97 324.5 0.2 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 CCF53373.1 - 1.4e-33 115.4 0.0 2.4e-33 114.7 0.0 1.3 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 CCF53373.1 - 2.1e-23 82.5 0.6 5.3e-23 81.3 0.6 1.7 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 CCF53373.1 - 3.5e-13 50.0 0.2 1.6e-12 47.9 0.1 2.1 2 0 0 2 2 2 1 MCM N-terminal domain Mg_chelatase PF01078.21 CCF53373.1 - 9.2e-08 31.7 0.0 1.1e-06 28.3 0.0 2.2 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 CCF53373.1 - 0.0038 17.1 0.0 0.0079 16.1 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 CCF53373.1 - 0.009 15.7 0.0 0.024 14.4 0.0 1.6 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_5 PF07728.14 CCF53373.1 - 0.091 12.8 0.0 0.26 11.3 0.0 1.8 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Arm PF00514.23 CCF53374.1 - 1.1e-07 31.6 32.0 0.0024 17.9 0.1 10.7 12 0 0 12 12 12 5 Armadillo/beta-catenin-like repeat HEAT PF02985.22 CCF53374.1 - 0.0036 17.4 17.5 1.4 9.4 0.1 8.1 8 0 0 8 8 8 2 HEAT repeat HEAT_EZ PF13513.6 CCF53374.1 - 0.011 16.2 21.0 1.9 9.1 0.1 8.0 9 1 1 10 10 10 0 HEAT-like repeat Complex1_30kDa PF00329.19 CCF53375.1 - 7.2e-47 159.0 0.0 9.8e-47 158.6 0.0 1.2 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 30 Kd subunit BCAS2 PF05700.11 CCF53376.1 - 1.6e-65 220.7 0.4 1.9e-65 220.4 0.4 1.1 1 0 0 1 1 1 1 Breast carcinoma amplified sequence 2 (BCAS2) Mesd PF10185.9 CCF53376.1 - 0.009 16.0 0.1 0.016 15.1 0.1 1.4 1 0 0 1 1 1 1 Chaperone for wingless signalling and trafficking of LDL receptor Enkurin PF13864.6 CCF53376.1 - 0.028 14.8 5.8 0.052 14.0 5.2 1.7 1 1 0 1 1 1 0 Calmodulin-binding Nup54 PF13874.6 CCF53376.1 - 0.41 10.7 8.6 0.29 11.2 6.7 1.7 2 1 0 2 2 2 0 Nucleoporin complex subunit 54 DUF5320 PF17253.2 CCF53376.1 - 0.63 11.1 2.8 30 5.8 0.2 2.6 3 0 0 3 3 3 0 Family of unknown function (DUF5320) DUF1264 PF06884.11 CCF53378.1 - 3e-63 212.5 0.0 4e-63 212.1 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1264) Zn_clus PF00172.18 CCF53379.1 - 3.3e-06 27.1 11.7 5.8e-06 26.3 11.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CBS PF00571.28 CCF53380.1 - 3.2e-27 94.8 9.0 3.9e-07 30.4 0.1 5.7 5 1 0 5 5 5 4 CBS domain PB1 PF00564.24 CCF53380.1 - 5.5e-07 29.4 0.0 1.3e-06 28.3 0.0 1.6 1 0 0 1 1 1 1 PB1 domain NYN PF01936.18 CCF53380.1 - 0.0088 16.5 0.1 0.018 15.5 0.1 1.4 1 0 0 1 1 1 1 NYN domain DUF2380 PF09533.10 CCF53380.1 - 0.012 15.3 1.5 1.6 8.3 0.0 2.6 2 0 0 2 2 2 0 Predicted lipoprotein of unknown function (DUF2380) DUF4604 PF15377.6 CCF53380.1 - 1.7 9.0 17.7 0.042 14.3 10.2 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4604) MMR_HSR1_Xtn PF16897.5 CCF53381.1 - 1.4e-39 134.4 2.2 2.4e-39 133.6 2.2 1.4 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain TGS PF02824.21 CCF53381.1 - 9.7e-20 70.4 0.0 1.9e-19 69.5 0.0 1.5 1 0 0 1 1 1 1 TGS domain MMR_HSR1 PF01926.23 CCF53381.1 - 1.1e-19 70.6 0.0 2.4e-19 69.5 0.0 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 CCF53381.1 - 6.2e-12 45.3 0.0 1.3e-11 44.3 0.0 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 CCF53381.1 - 0.005 16.9 0.7 1.9 8.5 0.0 3.0 2 1 0 3 3 3 1 Dynamin family AIG1 PF04548.16 CCF53381.1 - 0.027 13.8 0.0 0.044 13.1 0.0 1.4 1 0 0 1 1 1 0 AIG1 family Endonuc-FokI_C PF09254.11 CCF53381.1 - 0.092 12.0 0.0 0.23 10.7 0.0 1.6 2 0 0 2 2 2 0 Restriction endonuclease FokI, C terminal TMA7 PF09072.10 CCF53381.1 - 0.11 13.3 0.5 0.21 12.5 0.5 1.5 1 0 0 1 1 1 0 Translation machinery associated TMA7 AAA_16 PF13191.6 CCF53381.1 - 0.14 12.5 0.1 5.5 7.3 0.0 2.4 2 0 0 2 2 2 0 AAA ATPase domain TAP_C PF03943.13 CCF53382.1 - 9.1e-16 57.2 0.7 1.8e-15 56.3 0.7 1.5 1 0 0 1 1 1 1 TAP C-terminal domain LRR_9 PF14580.6 CCF53382.1 - 1.5e-05 24.6 0.0 2.5e-05 23.8 0.0 1.2 1 0 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.7 CCF53382.1 - 0.0018 18.6 5.0 0.0081 16.6 0.6 2.7 1 1 1 2 2 2 1 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 CCF53382.1 - 0.18 11.6 3.0 1.9 8.3 3.1 2.5 1 1 0 1 1 1 0 Leucine rich repeat UvrD-helicase PF00580.21 CCF53385.1 - 2.5e-68 230.9 0.2 2.5e-68 230.9 0.2 1.8 2 0 0 2 2 2 1 UvrD/REP helicase N-terminal domain UvrD_C PF13361.6 CCF53385.1 - 2.3e-57 194.9 0.0 8.1e-29 101.1 0.0 2.7 2 1 0 2 2 2 2 UvrD-like helicase C-terminal domain AAA_19 PF13245.6 CCF53385.1 - 1.4e-30 106.5 0.1 3e-30 105.5 0.1 1.5 1 0 0 1 1 1 1 AAA domain UvrD_C_2 PF13538.6 CCF53385.1 - 8.5e-13 47.9 0.0 2.3e-12 46.5 0.0 1.8 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_30 PF13604.6 CCF53385.1 - 2.9e-07 30.4 0.3 0.012 15.3 0.5 2.4 2 0 0 2 2 2 2 AAA domain Viral_helicase1 PF01443.18 CCF53385.1 - 3.7e-05 23.6 0.0 0.67 9.7 0.0 3.5 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase AAA_22 PF13401.6 CCF53385.1 - 0.0033 17.7 0.1 5.1 7.4 0.0 2.8 2 1 0 2 2 2 2 AAA domain AAA_12 PF13087.6 CCF53385.1 - 0.13 11.8 0.0 0.63 9.6 0.0 2.1 3 0 0 3 3 3 0 AAA domain PALP PF00291.25 CCF53386.1 - 3.1e-48 164.7 2.1 3.8e-48 164.4 1.3 1.5 1 1 1 2 2 2 1 Pyridoxal-phosphate dependent enzyme GTP_EFTU PF00009.27 CCF53387.1 - 2.9e-54 183.6 0.0 4.7e-54 182.9 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_II PF14492.6 CCF53387.1 - 5.3e-22 77.7 0.0 1.1e-21 76.7 0.0 1.6 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.24 CCF53387.1 - 1.3e-15 57.2 0.2 2.5e-07 30.6 0.0 2.6 2 0 0 2 2 2 2 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 CCF53387.1 - 4.1e-09 36.7 0.0 1.6e-08 34.8 0.0 2.1 2 0 0 2 2 2 1 Elongation factor Tu domain 2 RF3_C PF16658.5 CCF53387.1 - 0.00065 19.5 0.0 0.0012 18.6 0.0 1.4 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain MMR_HSR1 PF01926.23 CCF53387.1 - 0.0018 18.4 0.0 0.0048 17.0 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase FAP206 PF12018.8 CCF53389.1 - 7.6e-05 22.4 0.2 9.1e-05 22.1 0.2 1.1 1 0 0 1 1 1 1 Domain of unknown function NPIP PF06409.11 CCF53389.1 - 0.02 14.0 0.0 0.027 13.6 0.0 1.2 1 0 0 1 1 1 0 Nuclear pore complex interacting protein (NPIP) HCO3_cotransp PF00955.21 CCF53390.1 - 3.4e-58 197.7 12.8 2.5e-28 99.2 1.4 3.2 1 1 1 2 2 2 2 HCO3- transporter family YbgS PF13985.6 CCF53390.1 - 6.9 7.0 10.1 15 5.9 6.1 2.6 2 0 0 2 2 2 0 YbgS-like protein FHA PF00498.26 CCF53391.1 - 0.0013 19.1 0.1 0.0057 17.0 0.0 2.3 2 0 0 2 2 2 1 FHA domain OCRE PF17780.1 CCF53394.1 - 0.0077 16.2 0.1 0.0077 16.2 0.1 3.5 3 1 0 3 3 3 1 OCRE domain HK_sensor PF16750.5 CCF53394.1 - 0.03 14.6 1.1 0.074 13.4 1.1 1.6 1 0 0 1 1 1 0 Sensor domain of 2-component histidine kinase DAO_C PF16901.5 CCF53394.1 - 0.11 12.3 0.1 0.33 10.8 0.1 1.8 1 0 0 1 1 1 0 C-terminal domain of alpha-glycerophosphate oxidase AMP-binding PF00501.28 CCF53396.1 - 3.3e-71 240.1 0.0 4.4e-71 239.7 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme NAD_binding_4 PF07993.12 CCF53396.1 - 4.4e-66 222.7 0.0 6.8e-66 222.1 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein PP-binding PF00550.25 CCF53396.1 - 3.9e-13 49.6 0.0 1.2e-12 48.0 0.0 1.9 1 0 0 1 1 1 1 Phosphopantetheine attachment site Condensation PF00668.20 CCF53396.1 - 2e-10 40.0 0.0 3.7e-05 22.6 0.0 3.9 2 1 0 2 2 2 2 Condensation domain AMP-binding_C PF13193.6 CCF53396.1 - 3.4e-05 24.7 0.1 0.0053 17.7 0.1 3.3 1 1 0 1 1 1 1 AMP-binding enzyme C-terminal domain 3Beta_HSD PF01073.19 CCF53396.1 - 0.0011 18.0 0.0 0.034 13.2 0.0 2.3 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 CCF53396.1 - 0.0029 17.1 0.1 0.01 15.3 0.1 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Glyco_transf_28 PF03033.20 CCF53397.1 - 1e-13 51.5 0.0 1.4e-13 51.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain DUF1688 PF07958.11 CCF53399.1 - 9.9e-167 554.9 0.0 1.2e-166 554.7 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1688) DUF3692 PF12469.8 CCF53399.1 - 0.093 12.9 0.0 0.34 11.1 0.0 1.9 2 0 0 2 2 2 0 CRISPR-associated protein ABC2_membrane PF01061.24 CCF53400.1 - 1.5e-37 129.1 17.1 1.5e-37 129.1 17.1 2.3 3 0 0 3 3 3 1 ABC-2 type transporter ABC_tran PF00005.27 CCF53400.1 - 2.5e-25 89.6 0.0 4.5e-25 88.8 0.0 1.4 1 0 0 1 1 1 1 ABC transporter ABC2_membrane_3 PF12698.7 CCF53400.1 - 3.8e-06 26.2 23.8 9.3e-06 25.0 23.8 1.7 1 0 0 1 1 1 1 ABC-2 family transporter protein AAA_21 PF13304.6 CCF53400.1 - 0.0025 17.7 0.0 0.042 13.6 0.0 2.2 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 CCF53400.1 - 0.0082 15.9 0.1 0.019 14.7 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.6 CCF53400.1 - 0.014 15.8 0.0 0.031 14.7 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain AAA_28 PF13521.6 CCF53400.1 - 0.016 15.4 0.0 0.028 14.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 CCF53400.1 - 0.027 14.6 0.0 0.048 13.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 CCF53400.1 - 0.033 14.1 0.1 0.08 12.8 0.0 1.6 2 0 0 2 2 1 0 RsgA GTPase AAA_18 PF13238.6 CCF53400.1 - 0.049 14.2 0.0 0.089 13.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 CCF53400.1 - 0.061 12.9 0.1 0.11 12.1 0.1 1.3 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 CCF53400.1 - 0.11 13.0 0.0 0.22 12.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain SMC_N PF02463.19 CCF53400.1 - 0.13 11.6 0.0 0.46 9.9 0.0 1.7 1 1 0 1 1 1 0 RecF/RecN/SMC N terminal domain NACHT PF05729.12 CCF53400.1 - 0.17 11.8 0.1 0.34 10.8 0.1 1.5 1 0 0 1 1 1 0 NACHT domain TsaE PF02367.17 CCF53400.1 - 0.21 11.6 0.0 0.39 10.7 0.0 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Hemerythrin PF01814.23 CCF53402.1 - 3.7e-17 63.2 0.1 6e-12 46.3 0.0 2.1 1 1 1 2 2 2 2 Hemerythrin HHE cation binding domain TBCC_N PF16752.5 CCF53402.1 - 0.00017 22.0 0.0 0.19 12.2 0.0 2.2 2 0 0 2 2 2 2 Tubulin-specific chaperone C N-terminal domain YhdB PF14148.6 CCF53402.1 - 0.012 15.7 0.5 0.027 14.5 0.1 1.8 2 0 0 2 2 2 0 YhdB-like protein DUF4495 PF14906.6 CCF53402.1 - 0.07 12.2 0.4 0.084 11.9 0.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4495) LRR_4 PF12799.7 CCF53403.1 - 7.2e-26 89.8 33.6 4.3e-05 23.8 0.4 9.8 7 3 3 10 10 10 7 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 CCF53403.1 - 2e-21 75.5 26.7 5.9e-07 29.2 1.0 6.4 4 2 2 6 6 6 5 Leucine rich repeat LRR_9 PF14580.6 CCF53403.1 - 1.3e-08 34.6 12.6 0.0012 18.3 0.6 4.0 2 1 2 4 4 4 3 Leucine-rich repeat LRR_1 PF00560.33 CCF53403.1 - 0.046 14.3 30.3 9.8 7.2 0.6 10.8 11 1 0 11 11 11 0 Leucine Rich Repeat LRR_6 PF13516.6 CCF53403.1 - 0.086 12.9 21.0 1.5 9.1 0.5 7.7 9 0 0 9 9 9 0 Leucine Rich repeat MAP65_ASE1 PF03999.12 CCF53404.1 - 3.1e-64 217.8 0.1 6.5e-58 196.9 0.0 2.2 2 0 0 2 2 2 2 Microtubule associated protein (MAP65/ASE1 family) DUF1192 PF06698.11 CCF53404.1 - 1 9.5 4.6 1 9.5 0.2 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1192) YabA PF06156.13 CCF53404.1 - 1.7 9.3 3.5 2.1 9.1 0.1 2.9 3 0 0 3 3 3 0 Initiation control protein YabA BCDHK_Adom3 PF10436.9 CCF53405.1 - 7.9e-43 146.1 0.3 1.1e-42 145.7 0.3 1.2 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 CCF53405.1 - 2.8e-08 34.3 0.0 0.00063 20.2 0.0 2.5 2 0 0 2 2 2 2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PGP_phosphatase PF09419.10 CCF53406.1 - 1.6e-47 161.2 0.1 4.5e-43 146.8 0.0 2.5 1 1 1 2 2 2 2 Mitochondrial PGP phosphatase GCSF PF16647.5 CCF53406.1 - 0.002 18.0 0.0 0.0043 16.9 0.0 1.5 1 0 0 1 1 1 1 Granulocyte colony-stimulating factor DUF2373 PF10180.9 CCF53407.1 - 2.8e-13 49.5 0.4 1.2e-08 34.7 0.5 2.5 2 0 0 2 2 2 2 Uncharacterised conserved protein (DUF2373) TSP_1 PF00090.19 CCF53407.1 - 0.53 10.5 3.5 8 6.8 0.4 2.7 2 0 0 2 2 2 0 Thrombospondin type 1 domain SOBP PF15279.6 CCF53407.1 - 0.96 10.0 11.9 1.5 9.3 11.9 1.3 1 0 0 1 1 1 0 Sine oculis-binding protein CCDC106 PF15794.5 CCF53407.1 - 4 7.1 32.4 0.075 12.7 22.0 2.7 2 1 1 3 3 3 0 Coiled-coil domain-containing protein 106 TFIIF_alpha PF05793.12 CCF53407.1 - 4.3 5.8 47.4 0.51 8.9 20.7 2.7 1 1 1 2 2 2 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Macoilin PF09726.9 CCF53407.1 - 5.3 5.5 14.9 7.6 5.0 14.9 1.4 1 0 0 1 1 1 0 Macoilin family Vasculin PF15337.6 CCF53407.1 - 8.3 7.3 18.1 0.14 13.0 3.3 3.2 3 0 0 3 3 3 0 Vascular protein family Vasculin-like 1 PAP_RNA-bind PF04926.15 CCF53409.1 - 0.074 12.7 0.2 0.16 11.6 0.2 1.5 1 0 0 1 1 1 0 Poly(A) polymerase predicted RNA binding domain Lum_binding PF00677.17 CCF53410.1 - 1.8e-37 127.2 0.1 2.4e-18 65.9 0.0 2.3 2 0 0 2 2 2 2 Lumazine binding domain DUF2249 PF10006.9 CCF53412.1 - 0.0057 16.5 0.0 0.013 15.3 0.0 1.6 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2249) Homoserine_dh PF00742.19 CCF53414.1 - 3e-47 160.8 0.0 4.1e-47 160.3 0.0 1.2 1 0 0 1 1 1 1 Homoserine dehydrogenase NAD_binding_3 PF03447.16 CCF53414.1 - 2.4e-14 54.0 0.0 4.5e-14 53.1 0.0 1.5 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain BUD22 PF09073.10 CCF53415.1 - 3.2e-93 313.4 43.6 3.2e-93 313.4 43.6 2.2 2 0 0 2 2 2 1 BUD22 Utp14 PF04615.13 CCF53415.1 - 0.46 9.0 56.8 0.0018 17.0 37.3 2.1 2 0 0 2 2 2 0 Utp14 protein Peptidase_M20 PF01546.28 CCF53416.1 - 1.7e-31 109.5 0.0 2.3e-31 109.1 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 CCF53416.1 - 0.00078 19.3 0.0 0.0016 18.3 0.0 1.6 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 CCF53416.1 - 0.0013 18.4 0.0 0.0029 17.3 0.0 1.8 1 1 0 1 1 1 1 Peptidase family M28 GMC_oxred_N PF00732.19 CCF53417.1 - 4.4e-61 206.9 0.0 6.1e-61 206.4 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 CCF53417.1 - 3.7e-36 124.8 0.1 6.6e-36 124.0 0.1 1.4 1 0 0 1 1 1 1 GMC oxidoreductase Pyr_redox_2 PF07992.14 CCF53417.1 - 2.1e-05 23.9 0.0 0.019 14.2 0.0 3.1 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 CCF53417.1 - 9e-05 21.8 0.1 0.00022 20.6 0.1 1.5 1 0 0 1 1 1 1 Thi4 family Lycopene_cycl PF05834.12 CCF53417.1 - 0.00015 20.9 0.2 0.00055 19.1 0.0 1.8 2 0 0 2 2 2 1 Lycopene cyclase protein DAO PF01266.24 CCF53417.1 - 0.0017 18.0 0.4 0.0017 18.0 0.4 1.9 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 CCF53417.1 - 0.0024 17.2 0.3 0.38 10.0 0.0 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CCF53417.1 - 0.0081 16.4 0.2 0.019 15.2 0.2 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 CCF53417.1 - 0.01 15.0 1.8 0.059 12.4 0.5 2.2 2 0 0 2 2 2 0 FAD binding domain DLH PF01738.18 CCF53418.1 - 7.5e-20 71.4 0.6 8.8e-20 71.2 0.6 1.0 1 0 0 1 1 1 1 Dienelactone hydrolase family IR1-M PF12185.8 CCF53418.1 - 0.074 13.0 0.4 0.24 11.4 0.4 1.8 1 0 0 1 1 1 0 Nup358/RanBP2 E3 ligase domain Bot1p PF12298.8 CCF53419.1 - 0.025 14.7 1.5 0.04 14.1 0.3 1.9 2 0 0 2 2 2 0 Eukaryotic mitochondrial regulator protein PepSY_TM PF03929.16 CCF53419.1 - 0.14 11.8 1.1 0.42 10.2 0.0 1.8 1 1 0 1 1 1 0 PepSY-associated TM region FMO-like PF00743.19 CCF53420.1 - 2e-16 59.5 0.0 1.4e-15 56.7 0.0 2.1 1 1 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.14 CCF53420.1 - 4.2e-15 55.8 0.0 5.4e-12 45.6 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CCF53420.1 - 6.3e-14 51.9 0.0 1e-13 51.3 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CCF53420.1 - 1.3e-10 41.3 0.0 5.6e-08 32.9 0.0 3.4 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.6 CCF53420.1 - 6.2e-08 32.2 0.1 2.9e-06 26.7 0.0 2.4 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) DAO PF01266.24 CCF53420.1 - 2e-07 30.9 0.5 0.0046 16.6 0.0 3.5 2 1 0 3 3 3 2 FAD dependent oxidoreductase Pyr_redox PF00070.27 CCF53420.1 - 8.6e-06 26.2 0.1 0.018 15.6 0.0 2.8 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 CCF53420.1 - 1e-05 24.9 0.0 2.5e-05 23.6 0.0 1.6 2 0 0 2 2 2 1 Thi4 family Mqo PF06039.15 CCF53420.1 - 0.0043 15.7 0.0 0.18 10.3 0.0 2.1 2 0 0 2 2 2 1 Malate:quinone oxidoreductase (Mqo) Lycopene_cycl PF05834.12 CCF53420.1 - 0.005 15.9 0.1 1.3 8.0 0.0 2.9 3 0 0 3 3 3 1 Lycopene cyclase protein FAD_oxidored PF12831.7 CCF53420.1 - 0.0057 16.0 0.0 0.1 11.9 0.0 2.4 3 0 0 3 3 3 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 CCF53420.1 - 0.0088 15.2 0.0 0.036 13.1 0.0 2.0 3 0 0 3 3 3 1 FAD binding domain NAD_binding_7 PF13241.6 CCF53420.1 - 0.032 14.7 0.0 0.18 12.2 0.0 2.2 2 0 0 2 2 2 0 Putative NAD(P)-binding Shikimate_DH PF01488.20 CCF53420.1 - 0.12 12.4 0.0 1.5 8.9 0.0 2.2 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase Amino_oxidase PF01593.24 CCF53420.1 - 0.19 11.0 0.0 0.7 9.1 0.0 1.9 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase Amidohydro_1 PF01979.20 CCF53421.1 - 5.5e-11 42.4 0.0 0.00019 20.9 0.1 2.6 2 1 0 2 2 2 2 Amidohydrolase family Amidohydro_3 PF07969.11 CCF53421.1 - 9.7e-10 38.5 0.1 4.8e-06 26.3 0.0 2.3 2 0 0 2 2 2 2 Amidohydrolase family DUF3605 PF12239.8 CCF53422.1 - 3.1e-27 95.8 0.0 2.2e-18 67.1 0.0 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF3605) BcrAD_BadFG PF01869.20 CCF53423.1 - 1.7e-09 37.6 0.0 4.2e-05 23.2 0.0 2.3 2 0 0 2 2 2 2 BadF/BadG/BcrA/BcrD ATPase family Glucosamine_iso PF01182.20 CCF53424.1 - 3.5e-21 76.1 0.0 5.2e-21 75.6 0.0 1.2 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase DUF5109 PF17134.4 CCF53424.1 - 0.11 12.5 0.0 1.2 9.1 0.1 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF5109) Zn_clus PF00172.18 CCF53425.1 - 9.1e-08 32.1 9.3 2e-07 31.0 9.3 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PGM_PMM_I PF02878.16 CCF53426.1 - 6.3e-35 119.9 0.0 9.5e-35 119.3 0.0 1.3 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_II PF02879.16 CCF53426.1 - 1.7e-15 57.5 0.0 5.2e-15 55.9 0.0 1.8 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_III PF02880.16 CCF53426.1 - 4.2e-13 49.5 0.1 8.1e-13 48.6 0.1 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_IV PF00408.20 CCF53426.1 - 2.1e-08 34.2 0.1 5.8e-08 32.8 0.1 1.7 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain Lipase_3 PF01764.25 CCF53427.1 - 1.3e-11 44.5 0.0 3.4e-11 43.2 0.0 1.7 1 0 0 1 1 1 1 Lipase (class 3) DUF1479 PF07350.12 CCF53428.1 - 2.9e-142 474.3 0.0 3.5e-142 474.1 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1479) CAP_N PF01213.19 CCF53428.1 - 0.042 13.3 1.4 0.077 12.5 1.4 1.3 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal p450 PF00067.22 CCF53429.1 - 6.9e-55 186.6 0.0 9.1e-55 186.2 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Auts2 PF15336.6 CCF53431.1 - 0.14 12.3 1.3 0.16 12.1 0.1 1.6 1 1 1 2 2 2 0 Autism susceptibility gene 2 protein APS_kinase PF01583.20 CCF53433.1 - 1.2e-69 233.3 0.0 1.4e-69 233.0 0.0 1.0 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_33 PF13671.6 CCF53433.1 - 1.9e-06 28.1 0.0 3.2e-06 27.4 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 CCF53433.1 - 7e-05 23.4 0.0 0.00011 22.7 0.0 1.5 1 1 0 1 1 1 1 AAA domain KTI12 PF08433.10 CCF53433.1 - 0.00078 19.0 0.0 0.00093 18.7 0.0 1.2 1 0 0 1 1 1 1 Chromatin associated protein KTI12 Zeta_toxin PF06414.12 CCF53433.1 - 0.0089 15.3 0.0 0.026 13.8 0.0 1.6 2 0 0 2 2 2 1 Zeta toxin AAA_29 PF13555.6 CCF53433.1 - 0.0089 15.7 0.0 0.015 15.0 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain DUF463 PF04317.12 CCF53433.1 - 0.054 12.4 0.0 0.08 11.9 0.0 1.2 1 0 0 1 1 1 0 YcjX-like family, DUF463 AAA_16 PF13191.6 CCF53433.1 - 0.054 13.9 0.1 0.11 12.9 0.0 1.3 1 1 0 1 1 1 0 AAA ATPase domain ABC_tran PF00005.27 CCF53433.1 - 0.06 13.9 0.0 0.14 12.6 0.0 1.5 1 1 0 1 1 1 0 ABC transporter GlcNAc-1_reg PF18440.1 CCF53433.1 - 0.1 12.9 0.0 0.64 10.3 0.0 2.0 2 0 0 2 2 2 0 Putative GlcNAc-1 phosphotransferase regulatory domain PRK PF00485.18 CCF53433.1 - 0.12 12.1 0.0 0.26 11.0 0.0 1.6 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family CPT PF07931.12 CCF53433.1 - 0.17 11.7 0.1 0.41 10.5 0.1 1.6 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein TctC PF03401.14 CCF53433.1 - 0.2 10.7 0.0 0.24 10.4 0.0 1.1 1 0 0 1 1 1 0 Tripartite tricarboxylate transporter family receptor MaoC_dehydrat_N PF13452.6 CCF53434.1 - 5.7e-10 39.4 0.0 7.9e-06 26.0 0.0 2.8 3 0 0 3 3 3 2 N-terminal half of MaoC dehydratase MaoC_dehydratas PF01575.19 CCF53434.1 - 0.0016 18.0 0.0 0.0031 17.1 0.0 1.4 1 0 0 1 1 1 1 MaoC like domain SelR PF01641.18 CCF53435.1 - 1.1e-50 170.7 0.2 1.5e-50 170.3 0.2 1.2 1 0 0 1 1 1 1 SelR domain WD40 PF00400.32 CCF53436.1 - 3.6e-13 49.8 11.1 0.00079 20.2 0.1 6.9 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF53436.1 - 5.5e-06 26.6 0.0 4.2 7.7 0.0 5.4 5 1 0 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 CCF53437.1 - 8.5e-05 23.2 11.6 0.17 12.8 0.4 4.8 4 0 0 4 4 4 2 WD domain, G-beta repeat AurF PF11583.8 CCF53437.1 - 0.24 10.6 0.6 0.39 9.9 0.6 1.3 1 0 0 1 1 1 0 P-aminobenzoate N-oxygenase AurF VID27_N PF17748.1 CCF53437.1 - 0.24 11.2 1.4 0.46 10.3 1.4 1.4 1 0 0 1 1 1 0 VID27 N-terminal region MBOAT_2 PF13813.6 CCF53438.1 - 0.00019 21.6 1.7 0.00044 20.5 1.7 1.7 1 1 0 1 1 1 1 Membrane bound O-acyl transferase family COX15-CtaA PF02628.15 CCF53438.1 - 0.076 12.1 0.0 0.11 11.5 0.0 1.2 1 0 0 1 1 1 0 Cytochrome oxidase assembly protein DEAD PF00270.29 CCF53439.1 - 9.8e-48 162.2 0.0 1.8e-47 161.4 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CCF53439.1 - 7.7e-33 113.2 0.0 1.6e-29 102.5 0.0 2.8 3 0 0 3 3 3 2 Helicase conserved C-terminal domain ResIII PF04851.15 CCF53439.1 - 1.8e-05 24.8 0.2 7.2e-05 22.8 0.0 2.1 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit CMS1 PF14617.6 CCF53439.1 - 0.0024 17.2 0.0 0.0024 17.2 0.0 3.3 2 1 0 2 2 1 1 U3-containing 90S pre-ribosomal complex subunit ERCC3_RAD25_C PF16203.5 CCF53439.1 - 0.036 13.3 0.0 0.036 13.3 0.0 2.1 3 0 0 3 3 2 0 ERCC3/RAD25/XPB C-terminal helicase Pertussis_S2S3 PF02918.15 CCF53439.1 - 0.13 12.2 0.0 0.28 11.1 0.0 1.5 1 0 0 1 1 1 0 Pertussis toxin, subunit 2 and 3, C-terminal domain PH_6 PF15406.6 CCF53439.1 - 0.38 11.0 0.1 0.38 11.0 0.1 2.9 3 0 0 3 3 3 0 Pleckstrin homology domain SR-25 PF10500.9 CCF53439.1 - 1.4 8.5 29.5 2.2 7.8 29.5 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein FAM176 PF14851.6 CCF53439.1 - 3.3 7.3 7.3 7.4 6.2 7.3 1.6 1 0 0 1 1 1 0 FAM176 family CDC45 PF02724.14 CCF53439.1 - 3.6 5.8 13.4 5.2 5.3 13.4 1.1 1 0 0 1 1 1 0 CDC45-like protein Ndc1_Nup PF09531.10 CCF53439.1 - 6.3 5.4 8.6 8.3 5.0 8.6 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup adh_short PF00106.25 CCF53440.1 - 1.1e-20 73.9 0.0 3.4e-13 49.5 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CCF53440.1 - 8.1e-16 58.3 0.0 1.3e-11 44.5 0.0 2.0 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF53440.1 - 9.7e-06 25.6 0.1 4.9e-05 23.3 0.1 1.9 2 0 0 2 2 2 1 KR domain NAD_binding_10 PF13460.6 CCF53440.1 - 0.012 15.5 0.0 0.022 14.6 0.0 1.4 1 0 0 1 1 1 0 NAD(P)H-binding EF-hand_8 PF13833.6 CCF53441.1 - 0.014 15.2 1.6 0.19 11.6 0.6 2.4 2 0 0 2 2 2 0 EF-hand domain pair EF-hand_1 PF00036.32 CCF53441.1 - 0.084 12.5 0.3 0.22 11.1 0.3 1.7 1 0 0 1 1 1 0 EF hand Ras PF00071.22 CCF53442.1 - 2.7e-52 176.7 0.0 3.2e-52 176.4 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CCF53442.1 - 1.5e-32 112.3 0.0 2e-32 111.9 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CCF53442.1 - 2.8e-11 43.2 0.0 3.7e-11 42.8 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 CCF53442.1 - 3.8e-05 23.2 0.0 4.8e-05 22.8 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 CCF53442.1 - 4.7e-05 23.0 0.0 0.0022 17.6 0.0 2.2 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 CCF53442.1 - 0.00017 21.6 0.0 0.00025 21.1 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_7 PF12775.7 CCF53442.1 - 0.0029 17.2 0.0 0.0043 16.6 0.0 1.2 1 0 0 1 1 1 1 P-loop containing dynein motor region DAP3 PF10236.9 CCF53442.1 - 0.007 15.6 0.0 0.016 14.4 0.0 1.5 2 0 0 2 2 2 1 Mitochondrial ribosomal death-associated protein 3 SRPRB PF09439.10 CCF53442.1 - 0.0095 15.4 0.0 0.014 14.8 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit RsgA_GTPase PF03193.16 CCF53442.1 - 0.011 15.7 0.0 2.7 7.9 0.0 2.2 2 0 0 2 2 2 0 RsgA GTPase ATPase PF06745.13 CCF53442.1 - 0.017 14.5 0.0 0.022 14.1 0.0 1.2 1 0 0 1 1 1 0 KaiC NACHT PF05729.12 CCF53442.1 - 0.017 15.0 0.0 0.031 14.2 0.0 1.3 1 0 0 1 1 1 0 NACHT domain TetR_C_16 PF17920.1 CCF53442.1 - 0.023 14.9 0.1 0.05 13.8 0.1 1.5 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain AAA_16 PF13191.6 CCF53442.1 - 0.024 15.0 0.1 0.04 14.3 0.1 1.5 1 1 0 1 1 1 0 AAA ATPase domain Sigma54_activat PF00158.26 CCF53442.1 - 0.024 14.3 0.0 0.059 13.1 0.0 1.6 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_22 PF13401.6 CCF53442.1 - 0.029 14.6 0.0 0.044 14.1 0.0 1.5 1 1 0 1 1 1 0 AAA domain DUF2075 PF09848.9 CCF53442.1 - 0.15 11.3 0.0 0.2 10.9 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Septin PF00735.18 CCF53442.1 - 0.23 10.7 0.0 0.3 10.3 0.0 1.1 1 0 0 1 1 1 0 Septin RWD PF05773.22 CCF53443.1 - 3.9e-19 69.0 0.1 3.9e-19 69.0 0.1 2.0 2 1 0 2 2 2 1 RWD domain DFRP_C PF16543.5 CCF53443.1 - 3.9e-05 24.1 12.2 3.9e-05 24.1 12.2 3.2 2 1 1 3 3 3 1 DRG Family Regulatory Proteins, Tma46 DUF913 PF06025.12 CCF53443.1 - 0.33 9.9 4.4 0.46 9.4 4.4 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) FancD2 PF14631.6 CCF53443.1 - 0.4 8.0 5.2 0.47 7.8 5.2 1.0 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease SPARC_Ca_bdg PF10591.9 CCF53443.1 - 0.5 10.7 5.1 0.44 10.9 0.3 2.3 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region DUF932 PF06067.11 CCF53443.1 - 2.4 7.9 6.9 3.3 7.4 6.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF932) HlyIII PF03006.20 CCF53444.1 - 9.1e-54 182.5 23.7 9.1e-54 182.5 23.7 2.7 2 1 0 2 2 2 1 Haemolysin-III related TMEM238 PF15125.6 CCF53444.1 - 1.4 9.2 6.6 2.2 8.6 2.3 3.0 2 0 0 2 2 2 0 TMEM238 protein family PhoPQ_related PF10142.9 CCF53447.1 - 0.012 14.3 0.0 0.017 13.8 0.0 1.3 1 0 0 1 1 1 0 PhoPQ-activated pathogenicity-related protein Cyt-b5 PF00173.28 CCF53448.1 - 1.7e-24 85.7 0.1 1.9e-24 85.6 0.1 1.0 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Rit1_C PF17184.4 CCF53449.1 - 3.2e-94 315.4 0.0 4.8e-94 314.8 0.0 1.3 1 0 0 1 1 1 1 Rit1 N-terminal domain Init_tRNA_PT PF04179.12 CCF53449.1 - 1.1e-27 96.6 0.1 3.8e-27 94.8 0.2 1.9 2 0 0 2 2 2 1 Rit1 DUSP-like domain DSPc PF00782.20 CCF53449.1 - 0.00076 19.3 0.0 0.0018 18.1 0.0 1.6 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 CCF53449.1 - 0.081 12.9 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 Tyrosine phosphatase family HORMA PF02301.18 CCF53450.1 - 0.0071 15.9 0.0 0.012 15.2 0.0 1.4 1 0 0 1 1 1 1 HORMA domain SR-25 PF10500.9 CCF53450.1 - 1.9 8.1 8.0 0.11 12.0 1.8 1.9 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein E1-E2_ATPase PF00122.20 CCF53452.1 - 1.1e-41 142.4 8.4 1e-32 113.1 0.7 2.6 2 0 0 2 2 2 2 E1-E2 ATPase Cation_ATPase_C PF00689.21 CCF53452.1 - 1.2e-28 100.1 2.3 1.2e-28 100.1 2.3 2.2 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 CCF53452.1 - 1.2e-22 81.3 0.1 1.6e-20 74.3 0.1 2.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 CCF53452.1 - 2.3e-20 72.5 0.1 4.1e-20 71.6 0.1 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 CCF53452.1 - 1.9e-14 53.1 0.0 5.1e-14 51.7 0.0 1.8 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus DctM PF06808.12 CCF53452.1 - 0.00019 20.4 0.1 0.00019 20.4 0.1 1.9 2 0 0 2 2 2 1 Tripartite ATP-independent periplasmic transporter, DctM component Hydrolase_3 PF08282.12 CCF53452.1 - 0.00041 20.2 0.9 0.0041 16.9 1.1 2.2 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase MoeA_N PF03453.17 CCF53452.1 - 0.43 10.3 1.9 1.1 9.0 0.0 2.4 2 1 0 2 2 2 0 MoeA N-terminal region (domain I and II) MaoC_dehydratas PF01575.19 CCF53454.1 - 1.7e-27 95.4 0.0 1.2e-26 92.7 0.0 2.3 1 1 0 1 1 1 1 MaoC like domain MaoC_dehydrat_N PF13452.6 CCF53454.1 - 2.1e-09 37.6 0.0 8.3e-08 32.4 0.0 2.4 2 1 0 2 2 2 1 N-terminal half of MaoC dehydratase BAR PF03114.18 CCF53455.1 - 1.6e-44 152.4 5.4 2.4e-44 151.8 5.4 1.2 1 0 0 1 1 1 1 BAR domain SH3_1 PF00018.28 CCF53455.1 - 3.3e-15 55.4 0.0 6.9e-15 54.4 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 CCF53455.1 - 7.1e-15 54.6 0.1 2.9e-14 52.6 0.1 1.9 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.17 CCF53455.1 - 4.4e-10 39.1 0.0 9.8e-10 38.0 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain Prefoldin PF02996.17 CCF53455.1 - 0.041 13.8 0.6 0.38 10.7 0.0 2.4 2 1 0 2 2 2 0 Prefoldin subunit DUF1048 PF06304.11 CCF53455.1 - 0.062 13.8 0.1 12 6.4 0.0 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF1048) DUF3104 PF11302.8 CCF53455.1 - 0.2 11.4 0.0 0.38 10.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3104) COX16 PF14138.6 CCF53455.1 - 2.1 8.9 5.6 24 5.5 3.4 2.3 2 0 0 2 2 2 0 Cytochrome c oxidase assembly protein COX16 DUF1295 PF06966.12 CCF53457.1 - 1.2e-49 169.0 0.6 1.6e-49 168.6 0.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) PEMT PF04191.13 CCF53457.1 - 0.00037 20.9 0.0 0.0014 19.0 0.0 2.0 1 0 0 1 1 1 1 Phospholipid methyltransferase Steroid_dh PF02544.16 CCF53457.1 - 0.00046 20.2 1.2 0.00079 19.4 0.0 1.9 2 0 0 2 2 2 1 3-oxo-5-alpha-steroid 4-dehydrogenase ICMT PF04140.14 CCF53457.1 - 0.013 15.9 0.0 0.028 14.8 0.0 1.6 1 0 0 1 1 1 0 Isoprenylcysteine carboxyl methyltransferase (ICMT) family Methyltransf_16 PF10294.9 CCF53458.1 - 8.7e-15 54.9 0.0 8.9e-14 51.6 0.0 2.2 1 1 0 1 1 1 1 Lysine methyltransferase Methyltransf_12 PF08242.12 CCF53458.1 - 0.15 12.8 0.1 0.52 11.1 0.1 2.0 1 1 0 1 1 1 0 Methyltransferase domain Metallopep PF12044.8 CCF53459.1 - 7.1e-92 308.2 0.0 2.6e-74 250.4 0.0 2.1 2 0 0 2 2 2 2 Putative peptidase family Jacalin PF01419.17 CCF53459.1 - 0.015 15.2 0.0 0.026 14.5 0.0 1.4 1 0 0 1 1 1 0 Jacalin-like lectin domain Peptidase_M66 PF10462.9 CCF53459.1 - 0.25 10.2 0.3 0.44 9.4 0.3 1.3 1 0 0 1 1 1 0 Peptidase M66 Xan_ur_permease PF00860.20 CCF53460.1 - 1.8e-24 86.1 29.3 2.1e-24 86.0 26.0 2.2 2 1 0 2 2 2 1 Permease family Aldose_epim PF01263.20 CCF53462.1 - 4.4e-32 111.6 0.0 6.4e-32 111.1 0.0 1.2 1 0 0 1 1 1 1 Aldose 1-epimerase DUF5599 PF18141.1 CCF53462.1 - 0.012 15.9 0.1 0.034 14.4 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF5599) DUF2256 PF10013.9 CCF53463.1 - 2.2e-13 50.1 2.9 3.4e-13 49.5 2.9 1.3 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2256) DUF3253 PF11625.8 CCF53463.1 - 0.12 12.6 1.3 2.1 8.6 0.0 3.1 2 1 0 2 2 2 0 Protein of unknown function (DUF3253) RIC1 PF07064.13 CCF53464.1 - 3.6e-104 347.7 0.0 9.1e-104 346.3 0.0 1.7 1 1 0 1 1 1 1 RIC1 ANAPC4_WD40 PF12894.7 CCF53464.1 - 0.00011 22.5 0.1 1.5 9.2 0.0 4.6 5 2 0 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain SLC35F PF06027.12 CCF53464.1 - 0.12 11.9 0.0 0.63 9.5 0.0 1.8 2 0 0 2 2 2 0 Solute carrier family 35 PQ-loop PF04193.14 CCF53465.1 - 8.5e-33 111.9 8.4 1.4e-16 60.0 1.8 2.5 2 0 0 2 2 2 2 PQ loop repeat ECH_1 PF00378.20 CCF53466.1 - 1.7e-17 63.6 0.1 2.8e-17 62.9 0.1 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Formyl_trans_C PF02911.18 CCF53466.1 - 3.2e-05 24.1 0.0 7.8e-05 22.8 0.0 1.6 1 0 0 1 1 1 1 Formyl transferase, C-terminal domain MFS_1 PF07690.16 CCF53467.1 - 1.2e-31 110.0 24.6 1.2e-31 110.0 24.6 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily Trp_oprn_chp PF09534.10 CCF53467.1 - 0.073 12.9 0.0 0.42 10.4 0.0 2.1 2 1 0 2 2 2 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) MMM1 PF10296.9 CCF53468.1 - 5e-09 35.6 0.0 4.6e-07 29.2 0.0 2.2 2 0 0 2 2 2 2 Maintenance of mitochondrial morphology protein 1 RVT_2 PF07727.14 CCF53470.1 - 2.7e-16 59.9 0.0 4.2e-16 59.3 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) CIAPIN1 PF05093.13 CCF53471.1 - 5.5e-32 110.3 4.7 1.7e-31 108.6 4.7 1.9 1 0 0 1 1 1 1 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis DRE2_N PF16803.5 CCF53471.1 - 3.1e-08 34.0 0.0 4.9e-08 33.3 0.0 1.2 1 0 0 1 1 1 1 Fe-S cluster assembly protein DRE2 N-terminus WBS_methylT PF12589.8 CCF53472.1 - 3.3e-22 79.0 8.4 3.3e-22 79.0 8.4 1.7 2 0 0 2 2 2 1 Methyltransferase involved in Williams-Beuren syndrome Methyltransf_11 PF08241.12 CCF53472.1 - 5.3e-11 43.0 0.0 9.2e-11 42.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF53472.1 - 5.3e-09 36.7 0.0 1.1e-08 35.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCF53472.1 - 7.1e-07 29.2 0.0 1.1e-06 28.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF53472.1 - 8.1e-06 26.5 0.0 2.3e-05 25.1 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF53472.1 - 0.00036 20.4 0.0 0.00072 19.4 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain AdoMet_MTase PF07757.13 CCF53472.1 - 0.0095 16.3 0.0 0.074 13.4 0.0 2.2 2 0 0 2 2 2 1 Predicted AdoMet-dependent methyltransferase AFG1_ATPase PF03969.16 CCF53473.1 - 5.1e-54 183.5 0.1 2.9e-47 161.3 0.0 4.7 2 1 0 3 3 3 2 AFG1-like ATPase DnaJ PF00226.31 CCF53473.1 - 8.1e-19 67.5 1.8 1.6e-18 66.5 1.2 1.9 2 0 0 2 2 2 1 DnaJ domain AAA_16 PF13191.6 CCF53473.1 - 8.7e-06 26.2 0.1 6.7e-05 23.3 0.0 2.5 1 1 1 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 CCF53473.1 - 0.01 16.1 0.1 0.073 13.3 0.1 2.3 1 1 0 1 1 1 0 AAA domain AAA_19 PF13245.6 CCF53473.1 - 0.018 15.4 0.1 0.26 11.6 0.1 2.6 1 1 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 CCF53473.1 - 0.12 11.8 0.7 0.4 10.0 0.0 2.3 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI AAA_29 PF13555.6 CCF53473.1 - 0.13 12.0 0.1 0.37 10.6 0.1 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain GPI-anchored PF10342.9 CCF53478.1 - 0.0027 18.4 1.4 0.0027 18.4 1.4 1.8 2 0 0 2 2 2 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family DUF4493 PF14900.6 CCF53478.1 - 0.018 14.9 2.1 1.1 9.1 0.3 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4493) DUF2027 PF09640.10 CCF53478.1 - 0.1 12.2 0.1 0.17 11.5 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF2027) Fungal_trans PF04082.18 CCF53479.1 - 2.6e-31 108.6 0.0 5.3e-31 107.6 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF53479.1 - 2.7e-08 33.8 8.6 5.1e-08 32.9 8.6 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Serglycin PF04360.12 CCF53479.1 - 0.16 11.9 0.2 0.4 10.6 0.2 1.6 1 0 0 1 1 1 0 Serglycin DUF2222 PF09984.9 CCF53479.1 - 0.21 11.4 0.0 0.39 10.6 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised signal transduction histidine kinase domain (DUF2222) adh_short PF00106.25 CCF53480.1 - 9.7e-09 35.0 0.1 5.2e-05 22.8 0.1 2.6 2 1 0 2 2 2 2 short chain dehydrogenase KR PF08659.10 CCF53480.1 - 0.0068 16.3 2.7 0.05 13.5 0.4 2.2 2 0 0 2 2 2 1 KR domain GNAT_acetyltr_2 PF13718.6 CCF53480.1 - 0.12 11.8 0.1 0.32 10.4 0.0 1.7 2 0 0 2 2 2 0 GNAT acetyltransferase 2 Peptidase_S9 PF00326.21 CCF53482.1 - 2.1e-36 125.4 0.0 6.1e-25 87.9 0.0 2.2 2 0 0 2 2 2 2 Prolyl oligopeptidase family PIG-H PF10181.9 CCF53482.1 - 2.8e-11 43.1 0.0 5.8e-11 42.1 0.0 1.6 1 0 0 1 1 1 1 GPI-GlcNAc transferase complex, PIG-H component DLH PF01738.18 CCF53482.1 - 6e-07 29.2 0.0 1.1e-06 28.4 0.0 1.3 1 0 0 1 1 1 1 Dienelactone hydrolase family Hydrolase_4 PF12146.8 CCF53482.1 - 7.3e-05 22.2 2.5 0.00015 21.1 0.0 2.4 3 0 0 3 3 3 1 Serine aminopeptidase, S33 FSH1 PF03959.13 CCF53482.1 - 0.022 14.4 0.0 0.037 13.7 0.0 1.3 1 0 0 1 1 1 0 Serine hydrolase (FSH1) Abhydrolase_4 PF08386.10 CCF53482.1 - 0.033 14.3 0.0 0.081 13.1 0.0 1.6 1 0 0 1 1 1 0 TAP-like protein BAAT_C PF08840.11 CCF53482.1 - 0.19 11.6 0.0 0.43 10.5 0.0 1.5 1 0 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal Kinesin PF00225.23 CCF53483.1 - 4.8e-113 377.5 0.0 7.6e-113 376.8 0.0 1.3 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 CCF53483.1 - 4.8e-26 91.5 0.0 1.2e-25 90.2 0.0 1.7 1 0 0 1 1 1 1 Microtubule binding UPF0242 PF06785.11 CCF53483.1 - 0.16 12.0 1.3 0.47 10.5 1.3 1.8 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Snapin_Pallidin PF14712.6 CCF53483.1 - 0.84 10.1 7.5 21 5.6 1.9 3.5 2 1 2 4 4 4 0 Snapin/Pallidin YabA PF06156.13 CCF53483.1 - 4 8.1 6.5 4 8.1 2.8 2.8 1 1 1 2 2 2 0 Initiation control protein YabA eRF1_1 PF03463.15 CCF53484.1 - 3.3e-50 169.4 0.0 4.6e-50 168.9 0.0 1.2 1 0 0 1 1 1 1 eRF1 domain 1 eRF1_3 PF03465.15 CCF53484.1 - 2.9e-23 82.5 0.0 6.6e-23 81.4 0.0 1.7 1 0 0 1 1 1 1 eRF1 domain 3 eRF1_2 PF03464.15 CCF53484.1 - 4.1e-22 78.9 0.0 6.9e-22 78.2 0.0 1.4 1 0 0 1 1 1 1 eRF1 domain 2 L51_S25_CI-B8 PF05047.16 CCF53485.1 - 7.1e-13 48.3 0.0 9e-13 47.9 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain RAI16-like PF10257.9 CCF53486.1 - 1.1e-52 179.1 0.0 2.8e-52 177.8 0.0 1.5 1 1 0 1 1 1 1 Retinoic acid induced 16-like protein ATP12 PF07542.11 CCF53487.1 - 1.9e-38 131.4 0.0 3.1e-38 130.8 0.0 1.3 1 0 0 1 1 1 1 ATP12 chaperone protein Pex24p PF06398.11 CCF53488.1 - 1.2e-27 96.8 17.8 1.9e-18 66.6 0.0 3.1 3 0 0 3 3 3 3 Integral peroxisomal membrane peroxin PIG-S PF10510.9 CCF53489.1 - 1.2e-153 512.6 5.6 1.5e-153 512.4 5.6 1.1 1 0 0 1 1 1 1 Phosphatidylinositol-glycan biosynthesis class S protein Aldo_ket_red PF00248.21 CCF53491.1 - 3e-47 161.3 0.0 4e-45 154.3 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family zf-CCHC PF00098.23 CCF53492.1 - 0.0022 18.0 0.5 0.0041 17.1 0.5 1.5 1 0 0 1 1 1 1 Zinc knuckle FUSC_2 PF13515.6 CCF53493.1 - 2.5e-22 79.3 2.6 2.5e-22 79.3 2.6 2.8 3 0 0 3 3 3 1 Fusaric acid resistance protein-like ALMT PF11744.8 CCF53493.1 - 1e-13 51.0 7.3 2e-11 43.4 0.0 2.7 2 1 0 2 2 2 2 Aluminium activated malate transporter FUSC PF04632.12 CCF53493.1 - 1.4e-11 43.8 2.8 1.4e-11 43.8 2.8 3.8 3 1 0 3 3 3 1 Fusaric acid resistance protein family ArAE_2 PF10334.9 CCF53493.1 - 6.5e-10 39.2 0.0 2.8e-09 37.2 0.0 1.9 2 0 0 2 2 2 1 Aromatic acid exporter family member 2 Phage_holin_3_6 PF07332.11 CCF53493.1 - 0.062 13.3 5.5 0.2 11.7 5.5 1.9 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III NLRC4_HD2 PF17776.1 CCF53493.1 - 0.11 13.0 0.1 0.37 11.3 0.1 1.9 1 0 0 1 1 1 0 NLRC4 helical domain HD2 FUSC-like PF12805.7 CCF53493.1 - 1.3 8.0 5.6 3.2 6.7 2.5 2.7 2 1 0 2 2 2 0 FUSC-like inner membrane protein yccS Zn_clus PF00172.18 CCF53494.1 - 0.00092 19.3 8.2 0.0026 17.9 8.2 1.8 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Sec39 PF08314.11 CCF53495.1 - 1.3e-32 113.2 0.1 2.3e-32 112.4 0.1 1.5 1 0 0 1 1 1 1 Secretory pathway protein Sec39 Med21 PF11221.8 CCF53496.1 - 1.2e-24 87.1 4.0 1.6e-24 86.8 4.0 1.2 1 0 0 1 1 1 1 Subunit 21 of Mediator complex KfrA_N PF11740.8 CCF53496.1 - 0.0026 18.4 0.8 0.0043 17.7 0.8 1.3 1 0 0 1 1 1 1 Plasmid replication region DNA-binding N-term BRE1 PF08647.11 CCF53496.1 - 0.0047 17.0 0.5 0.0086 16.1 0.4 1.5 1 1 0 1 1 1 1 BRE1 E3 ubiquitin ligase DUF4618 PF15397.6 CCF53496.1 - 0.0087 15.5 0.3 0.011 15.1 0.3 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4618) Helo_like_N PF17111.5 CCF53496.1 - 0.03 13.7 2.6 0.58 9.5 0.7 2.2 1 1 1 2 2 2 0 Fungal N-terminal domain of STAND proteins Spc7 PF08317.11 CCF53496.1 - 0.084 11.7 1.0 0.12 11.2 1.0 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein PRKG1_interact PF15898.5 CCF53496.1 - 0.089 13.7 1.1 0.16 12.9 1.1 1.5 1 1 0 1 1 1 0 cGMP-dependent protein kinase interacting domain VWA_2 PF13519.6 CCF53496.1 - 0.091 13.4 0.0 0.11 13.1 0.0 1.3 1 0 0 1 1 1 0 von Willebrand factor type A domain DUF4407 PF14362.6 CCF53496.1 - 0.1 11.9 0.2 0.13 11.6 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF4191 PF13829.6 CCF53496.1 - 0.11 11.8 0.1 0.15 11.3 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4191) Macoilin PF09726.9 CCF53496.1 - 0.14 10.7 0.2 0.17 10.4 0.2 1.1 1 0 0 1 1 1 0 Macoilin family HalX PF08663.10 CCF53496.1 - 1.2 9.5 7.1 1.8 8.9 4.0 2.7 2 1 0 2 2 2 0 HalX domain DUF2730 PF10805.8 CCF53496.1 - 1.9 8.6 4.8 0.21 11.7 0.5 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2730) rve PF00665.26 CCF53498.1 - 0.0001 22.5 0.0 0.00017 21.8 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain RVT_2 PF07727.14 CCF53499.1 - 1.8e-31 109.6 0.0 2.2e-31 109.3 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) ICMT PF04140.14 CCF53501.1 - 6.2e-27 93.9 0.3 1.6e-26 92.6 0.3 1.7 1 0 0 1 1 1 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.13 CCF53501.1 - 1.2e-13 51.4 0.7 1.2e-13 51.4 0.7 1.8 2 0 0 2 2 2 1 Phospholipid methyltransferase NnrU PF07298.11 CCF53501.1 - 4.9e-06 26.2 2.3 9.7e-06 25.2 2.3 1.6 1 1 0 1 1 1 1 NnrU protein DUF1295 PF06966.12 CCF53501.1 - 2.6e-05 23.9 1.7 3.3e-05 23.5 1.7 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) DUF423 PF04241.15 CCF53501.1 - 0.016 15.4 1.0 0.045 14.0 1.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF423) TRP PF06011.12 CCF53502.1 - 9.6e-35 120.1 14.3 2.6e-34 118.7 14.3 1.7 1 1 0 1 1 1 1 Transient receptor potential (TRP) ion channel Zn_clus PF00172.18 CCF53503.1 - 7.2e-05 22.8 11.8 0.00015 21.8 11.8 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Zip PF02535.22 CCF53503.1 - 0.26 10.4 4.1 0.13 11.4 1.1 1.9 2 0 0 2 2 2 0 ZIP Zinc transporter DUF3808 PF10300.9 CCF53504.1 - 9.1e-82 275.3 1.2 3.3e-81 273.4 1.2 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF3808) TPR_4 PF07721.14 CCF53504.1 - 0.0034 17.8 0.4 0.049 14.3 0.4 3.1 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_12 PF13424.6 CCF53504.1 - 0.037 14.3 5.9 7.7 6.9 0.9 4.4 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_20 PF14561.6 CCF53504.1 - 0.045 14.1 0.5 0.17 12.2 0.1 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 CCF53504.1 - 0.045 14.6 1.5 3.9 8.5 0.7 3.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 CCF53504.1 - 0.37 11.1 8.8 0.33 11.3 0.3 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.6 CCF53504.1 - 0.57 10.7 2.7 2.9 8.5 0.3 3.3 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.17 CCF53504.1 - 0.6 10.4 17.1 0.064 13.4 1.0 5.7 4 2 2 6 6 6 0 Tetratricopeptide repeat YL1 PF05764.13 CCF53504.1 - 1.8 8.7 20.4 0.19 11.8 10.5 2.8 1 1 1 2 2 2 0 YL1 nuclear protein TPR_1 PF00515.28 CCF53504.1 - 2.2 8.2 5.6 1.6 8.6 0.4 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat PPP4R2 PF09184.11 CCF53504.1 - 4.4 6.8 7.1 9.3 5.7 7.1 1.5 1 0 0 1 1 1 0 PPP4R2 TPR_11 PF13414.6 CCF53504.1 - 5.2 6.8 7.2 34 4.2 0.4 4.0 3 0 0 3 3 3 0 TPR repeat Ribosomal_S18 PF01084.20 CCF53505.1 - 4.2e-18 65.3 0.0 8.2e-18 64.4 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S18 Spc29 PF17082.5 CCF53505.1 - 0.013 15.4 1.3 0.013 15.3 0.3 1.5 2 0 0 2 2 2 0 Spindle Pole Component 29 DUF4148 PF13663.6 CCF53505.1 - 5.5 7.3 8.8 12 6.1 2.5 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4148) WD40 PF00400.32 CCF53506.1 - 1.1e-07 32.3 11.5 1.3 10.0 0.1 6.8 7 0 0 7 7 7 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF53506.1 - 6.9e-05 23.1 0.0 0.12 12.7 0.0 3.3 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain MMS1_N PF10433.9 CCF53506.1 - 0.00058 18.6 0.0 0.00095 17.9 0.0 1.3 1 0 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term RAB3GAP2_N PF14655.6 CCF53506.1 - 0.0028 17.0 0.0 0.042 13.1 0.0 2.6 3 0 0 3 3 3 1 Rab3 GTPase-activating protein regulatory subunit N-terminus CDC45 PF02724.14 CCF53506.1 - 0.013 13.8 9.3 0.017 13.4 9.3 1.1 1 0 0 1 1 1 0 CDC45-like protein EIIBC-GUT_N PF03612.14 CCF53506.1 - 0.034 13.9 0.1 0.049 13.4 0.1 1.2 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Nup160 PF11715.8 CCF53506.1 - 0.044 12.4 0.8 0.57 8.8 0.1 2.2 2 1 0 2 2 2 0 Nucleoporin Nup120/160 PPP4R2 PF09184.11 CCF53506.1 - 0.075 12.6 11.3 0.1 12.2 11.3 1.1 1 0 0 1 1 1 0 PPP4R2 SDA1 PF05285.12 CCF53506.1 - 0.13 11.6 13.5 0.18 11.2 13.5 1.1 1 0 0 1 1 1 0 SDA1 Sigma70_ner PF04546.13 CCF53506.1 - 0.18 11.6 10.4 0.26 11.2 10.4 1.2 1 0 0 1 1 1 0 Sigma-70, non-essential region NOA36 PF06524.12 CCF53506.1 - 0.19 11.1 19.0 0.12 11.6 17.3 1.5 2 0 0 2 2 2 0 NOA36 protein RXT2_N PF08595.11 CCF53506.1 - 0.26 11.3 9.1 0.43 10.6 9.1 1.3 1 0 0 1 1 1 0 RXT2-like, N-terminal BUD22 PF09073.10 CCF53506.1 - 0.39 10.0 10.8 0.52 9.6 10.8 1.1 1 0 0 1 1 1 0 BUD22 Nop14 PF04147.12 CCF53506.1 - 0.4 8.8 15.2 0.52 8.5 15.2 1.0 1 0 0 1 1 1 0 Nop14-like family FAM176 PF14851.6 CCF53506.1 - 0.61 9.7 10.1 1 9.0 10.1 1.3 1 0 0 1 1 1 0 FAM176 family Pes-10 PF07149.11 CCF53506.1 - 0.65 9.0 15.6 0.89 8.5 15.6 1.1 1 0 0 1 1 1 0 Pes-10 Sporozoite_P67 PF05642.11 CCF53506.1 - 0.95 7.5 6.6 1.2 7.1 6.6 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Cwf_Cwc_15 PF04889.12 CCF53506.1 - 1.2 8.8 16.7 1.7 8.3 16.7 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DNA_pol_phi PF04931.13 CCF53506.1 - 1.3 7.1 22.7 1.7 6.6 22.7 1.1 1 0 0 1 1 1 0 DNA polymerase phi TFB6 PF17110.5 CCF53506.1 - 1.3 8.8 8.1 2.1 8.1 8.1 1.3 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH DUF4611 PF15387.6 CCF53506.1 - 1.3 9.2 12.3 2.7 8.3 12.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) YL1 PF05764.13 CCF53506.1 - 2.2 8.3 17.5 3.1 7.9 17.5 1.1 1 0 0 1 1 1 0 YL1 nuclear protein DUF2457 PF10446.9 CCF53506.1 - 2.4 7.2 25.9 3.4 6.7 25.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Astro_capsid_p PF12226.8 CCF53506.1 - 2.5 7.2 14.9 3.5 6.7 14.9 1.1 1 0 0 1 1 1 0 Turkey astrovirus capsid protein PI3K_1B_p101 PF10486.9 CCF53506.1 - 2.5 5.8 6.3 3.6 5.2 6.3 1.2 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit TipE PF16972.5 CCF53506.1 - 2.6 7.1 8.2 4 6.5 8.2 1.2 1 0 0 1 1 1 0 Na+ channel auxiliary subunit TipE RPN2_C PF18004.1 CCF53506.1 - 2.8 7.8 8.1 4.2 7.3 8.1 1.2 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain GCIP PF13324.6 CCF53506.1 - 4 7.0 8.6 5.9 6.4 8.6 1.2 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting TRAP_alpha PF03896.16 CCF53506.1 - 4.8 6.3 10.9 6.9 5.8 10.9 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit CobT PF06213.12 CCF53506.1 - 5.7 6.2 17.5 9 5.6 17.5 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Trypan_PARP PF05887.11 CCF53506.1 - 8.8 6.3 8.2 15 5.6 8.2 1.2 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) DUF4820 PF16091.5 CCF53506.1 - 9.6 5.5 6.3 15 4.9 6.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) Cactin_mid PF10312.9 CCF53507.1 - 6.6e-64 215.3 9.6 6.6e-64 215.3 9.6 2.3 3 0 0 3 3 3 1 Conserved mid region of cactin CactinC_cactus PF09732.9 CCF53507.1 - 8.8e-60 200.1 6.0 1.5e-59 199.4 6.0 1.4 1 0 0 1 1 1 1 Cactus-binding C-terminus of cactin protein AD PF09793.9 CCF53508.1 - 1.2e-19 70.2 0.0 2.4e-19 69.2 0.0 1.5 1 0 0 1 1 1 1 Anticodon-binding domain NPC1_N PF16414.5 CCF53509.1 - 4.7e-79 265.4 3.3 6.9e-79 264.9 3.3 1.2 1 0 0 1 1 1 1 Niemann-Pick C1 N terminus Patched PF02460.18 CCF53509.1 - 1.4e-55 188.8 0.4 5e-28 97.7 0.0 2.6 2 0 0 2 2 2 2 Patched family Sterol-sensing PF12349.8 CCF53509.1 - 2.2e-43 147.7 9.3 1.3e-21 77.1 0.3 3.5 3 0 0 3 3 3 2 Sterol-sensing domain of SREBP cleavage-activation Folate_rec PF03024.14 CCF53509.1 - 0.002 18.0 2.8 0.0046 16.9 2.8 1.5 1 0 0 1 1 1 1 Folate receptor family ACR_tran PF00873.19 CCF53509.1 - 0.14 9.7 0.6 0.21 9.2 0.6 1.1 1 0 0 1 1 1 0 AcrB/AcrD/AcrF family CHZ PF09649.10 CCF53511.1 - 5.2e-12 45.0 0.2 5.2e-12 45.0 0.2 2.9 3 0 0 3 3 3 1 Histone chaperone domain CHZ PBP_like PF12727.7 CCF53511.1 - 0.023 13.8 0.1 0.027 13.6 0.1 1.1 1 0 0 1 1 1 0 PBP superfamily domain Sporozoite_P67 PF05642.11 CCF53511.1 - 8.4 4.3 8.1 8.6 4.3 8.1 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen RNA_pol_Rpb4 PF03874.16 CCF53512.1 - 1.5e-25 89.9 1.0 2e-25 89.5 1.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb4 Ribosomal_L12_N PF16320.5 CCF53512.1 - 0.13 12.0 0.1 0.41 10.4 0.1 1.9 1 0 0 1 1 1 0 Ribosomal protein L7/L12 dimerisation domain DDOST_48kD PF03345.14 CCF53512.1 - 0.14 10.9 0.0 0.2 10.5 0.0 1.1 1 0 0 1 1 1 0 Oligosaccharyltransferase 48 kDa subunit beta WD40 PF00400.32 CCF53513.1 - 3.1e-26 91.1 8.8 1.2e-06 29.1 0.0 6.9 6 1 0 6 6 6 4 WD domain, G-beta repeat Sof1 PF04158.14 CCF53513.1 - 6.8e-25 87.2 11.8 1.1e-24 86.5 11.8 1.3 1 0 0 1 1 1 1 Sof1-like domain ANAPC4_WD40 PF12894.7 CCF53513.1 - 6.6e-07 29.5 0.0 1.1 9.6 0.0 4.4 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 CCF53513.1 - 0.0017 18.2 0.0 0.0048 16.8 0.0 1.7 2 0 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A Nucleoporin_N PF08801.11 CCF53513.1 - 0.011 14.5 0.1 3.8 6.1 0.0 3.1 3 0 0 3 3 3 0 Nup133 N terminal like Frtz PF11768.8 CCF53513.1 - 0.013 13.9 0.0 0.052 11.9 0.0 1.9 1 1 0 2 2 2 0 WD repeat-containing and planar cell polarity effector protein Fritz Ge1_WD40 PF16529.5 CCF53513.1 - 0.085 11.8 0.0 2.4 7.0 0.0 2.7 2 1 1 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 CCF53513.1 - 0.087 11.5 0.4 11 4.5 0.0 3.2 2 2 1 4 4 4 0 Nucleoporin Nup120/160 EIIA-man PF03610.16 CCF53513.1 - 0.21 11.9 0.0 0.6 10.4 0.0 1.7 2 0 0 2 2 2 0 PTS system fructose IIA component CBFB_NFYA PF02045.15 CCF53514.1 - 8.3e-22 77.6 13.4 8.3e-22 77.6 13.4 2.9 2 1 0 2 2 2 1 CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B ThuA PF06283.11 CCF53515.1 - 8.4e-45 153.6 0.0 1e-44 153.3 0.0 1.1 1 0 0 1 1 1 1 Trehalose utilisation DUF3446 PF11928.8 CCF53515.1 - 0.22 11.9 8.8 0.33 11.3 7.0 2.2 2 0 0 2 2 2 0 Early growth response N-terminal domain Kelch_4 PF13418.6 CCF53516.1 - 6.9e-28 96.4 5.0 7.4e-07 29.1 0.0 5.9 4 1 1 5 5 5 5 Galactose oxidase, central domain Kelch_3 PF13415.6 CCF53516.1 - 1.7e-26 91.9 6.2 7.2e-07 29.3 0.0 6.7 8 0 0 8 8 8 4 Galactose oxidase, central domain DUF4110 PF13422.6 CCF53516.1 - 2.7e-18 65.8 0.1 2.7e-18 65.8 0.1 2.1 3 0 0 3 3 3 1 Domain of unknown function (DUF4110) Kelch_5 PF13854.6 CCF53516.1 - 9.9e-16 57.3 5.2 5.1e-06 26.3 0.0 5.2 5 0 0 5 5 5 3 Kelch motif Kelch_6 PF13964.6 CCF53516.1 - 3.9e-14 52.3 4.5 0.00038 20.6 0.0 4.5 4 1 1 5 5 5 3 Kelch motif Kelch_1 PF01344.25 CCF53516.1 - 4.1e-14 51.9 2.9 2.7e-05 23.7 0.0 4.7 4 1 0 4 4 4 3 Kelch motif Kelch_2 PF07646.15 CCF53516.1 - 2.2e-13 49.6 0.5 0.0052 16.7 0.0 5.0 5 0 0 5 5 5 3 Kelch motif Acetyltransf_6 PF13480.7 CCF53516.1 - 0.12 12.5 0.0 0.45 10.7 0.0 1.9 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain LPP20 PF02169.16 CCF53516.1 - 8.2 6.9 12.7 1.4 9.3 5.6 2.4 2 0 0 2 2 2 0 LPP20 lipoprotein ECH_1 PF00378.20 CCF53517.1 - 2.2e-20 73.0 0.0 1.1e-17 64.3 0.0 2.7 2 1 0 2 2 2 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 CCF53517.1 - 2e-08 34.1 0.0 2.7e-08 33.7 0.0 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Serglycin PF04360.12 CCF53519.1 - 0.024 14.6 5.0 0.047 13.6 2.5 2.0 1 1 1 2 2 2 0 Serglycin Actin PF00022.19 CCF53520.1 - 3.2e-126 421.2 0.0 1.4e-125 419.1 0.0 1.7 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 CCF53520.1 - 0.00012 21.0 0.0 0.0023 16.8 0.0 2.3 1 1 0 1 1 1 1 MreB/Mbl protein RVT_2 PF07727.14 CCF53521.1 - 5.9e-19 68.7 0.4 1e-09 38.4 0.1 2.3 1 1 0 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) Cu_amine_oxidN2 PF02727.16 CCF53521.1 - 0.079 13.2 0.0 0.27 11.5 0.0 1.8 2 0 0 2 2 2 0 Copper amine oxidase, N2 domain DUF1077 PF06417.12 CCF53522.1 - 3.4e-45 152.9 1.6 4.4e-45 152.5 1.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1077) EMP70 PF02990.16 CCF53522.1 - 0.043 12.5 0.1 0.049 12.3 0.1 1.1 1 0 0 1 1 1 0 Endomembrane protein 70 DHQ_synthase PF01761.20 CCF53523.1 - 1.1e-48 165.6 0.0 1.6e-48 165.2 0.0 1.1 1 0 0 1 1 1 1 3-dehydroquinate synthase Fe-ADH_2 PF13685.6 CCF53523.1 - 2.6e-11 43.7 0.0 3.5e-11 43.3 0.0 1.2 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Rad17 PF03215.15 CCF53524.1 - 2.2e-19 70.1 0.0 6.6e-19 68.6 0.0 1.7 1 1 0 1 1 1 1 Rad17 P-loop domain AAA_16 PF13191.6 CCF53524.1 - 0.00069 20.0 1.1 0.017 15.5 0.3 3.1 2 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 CCF53524.1 - 0.0027 18.0 0.0 0.016 15.4 0.0 2.4 2 1 0 2 2 2 1 AAA domain AAA_30 PF13604.6 CCF53524.1 - 0.0084 15.8 0.2 0.023 14.4 0.2 1.7 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.27 CCF53524.1 - 0.014 15.9 0.0 0.04 14.4 0.0 1.7 1 0 0 1 1 1 0 ABC transporter AAA_29 PF13555.6 CCF53524.1 - 0.041 13.6 0.0 0.11 12.2 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain IBN_N PF03810.19 CCF53525.1 - 5.1e-14 51.9 0.0 1.9e-13 50.1 0.0 2.1 2 0 0 2 2 2 1 Importin-beta N-terminal domain Cse1 PF08506.10 CCF53525.1 - 1.7e-08 33.7 0.0 6.3e-08 31.8 0.0 2.0 2 0 0 2 2 2 1 Cse1 Xpo1 PF08389.12 CCF53525.1 - 0.015 15.3 0.0 0.11 12.5 0.0 2.6 2 0 0 2 2 2 0 Exportin 1-like protein HEAT PF02985.22 CCF53525.1 - 0.017 15.4 0.4 0.82 10.1 0.0 3.8 3 0 0 3 3 3 0 HEAT repeat DUF3437 PF11919.8 CCF53525.1 - 0.05 13.5 0.0 0.81 9.6 0.0 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF3437) HEAT_EZ PF13513.6 CCF53525.1 - 0.056 14.0 5.0 0.38 11.3 0.1 4.3 4 0 0 4 4 4 0 HEAT-like repeat Translin PF01997.16 CCF53526.1 - 2.2e-39 135.6 0.0 2.8e-39 135.2 0.0 1.1 1 0 0 1 1 1 1 Translin family Tweety PF04906.13 CCF53526.1 - 0.0069 15.1 0.0 0.01 14.5 0.0 1.2 1 0 0 1 1 1 1 Tweety BLOC1_2 PF10046.9 CCF53526.1 - 0.035 14.4 1.3 3 8.2 0.1 2.7 2 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Ribosomal_L1 PF00687.21 CCF53527.1 - 1.1e-51 175.4 0.1 1.1e-51 175.4 0.1 2.0 2 2 0 2 2 2 1 Ribosomal protein L1p/L10e family Motile_Sperm PF00635.26 CCF53528.1 - 3.4e-25 88.0 0.1 5.6e-25 87.3 0.1 1.4 1 0 0 1 1 1 1 MSP (Major sperm protein) domain ASH PF15780.5 CCF53528.1 - 2.5e-05 24.4 0.1 5.4e-05 23.3 0.1 1.5 1 0 0 1 1 1 1 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin SPG4 PF17325.2 CCF53528.1 - 0.056 14.5 1.4 0.52 11.4 0.1 2.3 1 1 1 2 2 2 0 Stationary phase protein 4 DUF1811 PF08838.10 CCF53528.1 - 0.13 12.5 0.2 0.5 10.6 0.0 2.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1811) DUF1192 PF06698.11 CCF53528.1 - 0.68 10.0 4.9 0.46 10.6 0.3 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF1192) DUF4336 PF14234.6 CCF53529.1 - 2.2e-08 33.7 0.1 0.27 10.4 0.0 3.1 3 0 0 3 3 3 3 Domain of unknown function (DUF4336) IML1 PF12257.8 CCF53531.1 - 3.3e-114 380.8 0.0 5e-114 380.2 0.0 1.3 1 0 0 1 1 1 1 Vacuolar membrane-associated protein Iml1 DEP PF00610.21 CCF53531.1 - 6.6e-20 70.9 0.2 1.5e-19 69.8 0.2 1.7 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) PAP2_3 PF14378.6 CCF53532.1 - 1.4e-19 70.5 18.7 1.4e-19 70.5 18.7 2.1 1 1 1 2 2 2 1 PAP2 superfamily PAP2 PF01569.21 CCF53532.1 - 6.1e-06 26.0 17.5 3.4e-05 23.6 17.2 2.5 1 1 0 1 1 1 1 PAP2 superfamily DUF4449 PF14613.6 CCF53533.1 - 1.3e-07 31.9 0.0 1.3e-07 31.9 0.0 5.2 4 2 1 5 5 5 2 Protein of unknown function (DUF4449) Nexin_C PF08628.12 CCF53533.1 - 0.045 14.3 0.3 0.24 12.0 0.0 2.4 2 0 0 2 2 2 0 Sorting nexin C terminal CorA PF01544.18 CCF53533.1 - 0.21 10.9 5.1 0.27 10.5 3.0 2.3 1 1 0 1 1 1 0 CorA-like Mg2+ transporter protein Nif11 PF07862.11 CCF53533.1 - 0.36 11.2 11.4 12 6.3 0.0 5.5 6 0 0 6 6 6 0 Nif11 domain DUF4268 PF14088.6 CCF53533.1 - 1.7 8.5 6.5 0.32 10.8 0.3 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF4268) HisKA_3 PF07730.13 CCF53533.1 - 5.5 7.6 15.5 10 6.7 0.0 6.5 5 2 0 6 6 6 0 Histidine kinase DUF883 PF05957.13 CCF53533.1 - 6.4 7.4 34.7 0.4 11.3 0.2 6.6 4 1 3 7 7 7 0 Bacterial protein of unknown function (DUF883) Ribosomal_60s PF00428.19 CCF53533.1 - 9.8 6.9 12.0 0.7 10.5 0.2 3.4 3 0 0 3 3 3 0 60s Acidic ribosomal protein Sugar_tr PF00083.24 CCF53534.1 - 3.6e-103 345.9 24.4 4.3e-103 345.6 24.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF53534.1 - 1.3e-17 63.8 44.2 1.2e-11 44.2 17.0 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily GST_C_6 PF17171.4 CCF53535.1 - 0.11 12.4 0.0 0.45 10.3 0.0 2.0 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain DUF2418 PF10332.9 CCF53536.1 - 1.9e-26 92.4 0.1 1.9e-26 92.4 0.1 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF2418) PepSY_TM PF03929.16 CCF53536.1 - 0.02 14.6 0.0 0.039 13.6 0.0 1.5 1 1 0 1 1 1 0 PepSY-associated TM region zf-CCCH PF00642.24 CCF53537.1 - 2.3e-10 40.1 16.6 1.9e-06 27.7 2.9 2.3 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Defensin_int PF17858.1 CCF53537.1 - 0.11 12.5 1.2 0.26 11.3 1.2 1.6 1 0 0 1 1 1 0 Platypus intermediate defensin-like peptide oligo_HPY PF08352.12 CCF53537.1 - 1.9 9.1 5.1 3.6 8.2 1.1 2.6 2 0 0 2 2 2 0 Oligopeptide/dipeptide transporter, C-terminal region zf_CCCH_4 PF18345.1 CCF53537.1 - 9.9 6.4 17.3 1.2 9.3 2.5 2.7 2 1 0 2 2 2 0 Zinc finger domain DUF3512 PF12024.8 CCF53538.1 - 3.9e-05 23.2 0.2 0.00012 21.7 0.2 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF3512) WD40 PF00400.32 CCF53539.1 - 5e-18 65.1 5.8 6.3e-05 23.7 0.1 6.3 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF53539.1 - 8.1e-16 58.1 3.4 6.4e-05 23.2 0.0 5.2 2 1 3 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CCF53539.1 - 2.5e-06 26.7 0.0 0.00025 20.1 0.0 3.0 2 1 0 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 CCF53539.1 - 9e-06 25.7 0.1 0.00051 20.0 0.1 2.9 1 1 1 2 2 2 1 Eukaryotic translation initiation factor eIF2A Nbas_N PF15492.6 CCF53539.1 - 0.00055 19.3 0.1 0.0034 16.8 0.0 2.1 2 0 0 2 2 2 1 Neuroblastoma-amplified sequence, N terminal IKI3 PF04762.12 CCF53539.1 - 0.0082 14.2 0.2 2 6.3 0.1 2.5 3 0 0 3 3 3 2 IKI3 family MCM PF00493.23 CCF53540.1 - 1e-98 328.9 0.0 1.4e-98 328.4 0.0 1.2 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 CCF53540.1 - 7.2e-38 129.3 0.8 1.3e-37 128.4 0.8 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 CCF53540.1 - 3.9e-26 91.3 3.4 9.1e-26 90.1 3.4 1.7 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 CCF53540.1 - 1.1e-16 61.3 0.0 3.4e-16 59.7 0.0 1.9 1 0 0 1 1 1 1 MCM N-terminal domain AAA_5 PF07728.14 CCF53540.1 - 6.1e-08 32.8 0.0 2e-07 31.1 0.0 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 CCF53540.1 - 4.8e-07 29.4 0.1 0.00025 20.5 0.0 2.3 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 CCF53540.1 - 0.00023 21.0 0.1 0.021 14.7 0.0 2.9 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 CCF53540.1 - 0.006 16.3 0.2 1.1 9.0 0.0 2.9 3 0 0 3 3 3 1 Sigma-54 interaction domain AAA_16 PF13191.6 CCF53540.1 - 0.014 15.8 1.7 0.11 12.9 0.0 3.0 1 1 0 2 2 2 0 AAA ATPase domain Vta1 PF04652.16 CCF53541.1 - 4e-50 169.6 2.4 6.4e-50 168.9 2.4 1.3 1 0 0 1 1 1 1 Vta1 like Vta1_C PF18097.1 CCF53541.1 - 3.7e-13 48.9 0.1 8.2e-13 47.8 0.1 1.6 1 0 0 1 1 1 1 Vta1 C-terminal domain Ras PF00071.22 CCF53543.1 - 2.3e-54 183.4 0.0 2.7e-54 183.2 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CCF53543.1 - 1.6e-20 73.5 0.0 2.7e-20 72.8 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CCF53543.1 - 2.4e-07 30.4 0.0 2.7e-07 30.2 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 CCF53543.1 - 0.00059 19.4 0.2 0.0055 16.3 0.0 2.1 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 CCF53543.1 - 0.0022 17.9 0.1 0.83 9.5 0.0 2.2 1 1 1 2 2 2 2 RsgA GTPase Gtr1_RagA PF04670.12 CCF53543.1 - 0.0087 15.4 0.0 0.011 15.1 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region FeoB_N PF02421.18 CCF53543.1 - 0.019 14.5 0.1 0.13 11.8 0.1 2.3 1 1 0 1 1 1 0 Ferrous iron transport protein B CbiA PF01656.23 CCF53543.1 - 0.04 14.0 0.3 0.14 12.2 0.3 1.9 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_25 PF13481.6 CCF53543.1 - 0.13 11.8 0.0 0.23 11.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 CCF53543.1 - 0.14 12.5 0.1 0.29 11.5 0.1 1.7 1 1 0 1 1 1 0 AAA ATPase domain Iwr1 PF08574.10 CCF53544.1 - 4e-07 30.9 9.8 1.5e-06 29.1 7.1 4.1 4 0 0 4 4 4 2 Transcription factor Iwr1 DUF4226 PF10774.9 CCF53544.1 - 0.54 10.6 4.0 0.41 11.0 1.7 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4226) Rhomboid PF01694.22 CCF53545.1 - 4e-28 98.3 11.5 4e-28 98.3 11.5 1.8 3 0 0 3 3 3 1 Rhomboid family Intg_mem_TP0381 PF09529.10 CCF53545.1 - 0.0024 17.4 0.2 0.0024 17.4 0.2 2.3 3 0 0 3 3 3 1 Integral membrane protein (intg_mem_TP0381) MNHE PF01899.16 CCF53545.1 - 7.6 6.3 6.8 1.6 8.5 0.0 2.5 3 0 0 3 3 3 0 Na+/H+ ion antiporter subunit Glyco_hydro_72 PF03198.14 CCF53546.1 - 7.1e-38 130.6 0.0 1.1e-37 130.0 0.0 1.2 1 0 0 1 1 1 1 Glucanosyltransferase X8 PF07983.13 CCF53546.1 - 1.2e-16 61.1 4.5 2.9e-16 59.9 4.5 1.6 1 0 0 1 1 1 1 X8 domain Glucan_synthase PF02364.15 CCF53547.1 - 0 1307.8 0.0 0 1307.2 0.0 1.3 1 0 0 1 1 1 1 1,3-beta-glucan synthase component FKS1_dom1 PF14288.6 CCF53547.1 - 3.8e-40 137.2 0.0 1.1e-39 135.8 0.0 1.8 1 1 0 1 1 1 1 1,3-beta-glucan synthase subunit FKS1, domain-1 CENP-L PF13092.6 CCF53548.1 - 1.5e-09 38.2 0.0 5.8e-09 36.4 0.0 1.9 1 1 0 1 1 1 1 Kinetochore complex Sim4 subunit Fta1 Synaptobrevin PF00957.21 CCF53549.1 - 3.2e-14 52.5 0.6 6e-14 51.6 0.6 1.4 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.6 CCF53549.1 - 1.4e-12 47.5 0.0 2.7e-12 46.5 0.0 1.5 1 0 0 1 1 1 1 Regulated-SNARE-like domain Herpes_teg_N PF04843.12 CCF53549.1 - 0.11 12.1 0.1 0.2 11.3 0.1 1.3 1 0 0 1 1 1 0 Herpesvirus tegument protein, N-terminal conserved region DHHC PF01529.20 CCF53550.1 - 6.3e-35 120.2 11.4 6.3e-35 120.2 11.4 1.6 2 0 0 2 2 2 1 DHHC palmitoyltransferase Ribosomal_S27e PF01667.17 CCF53551.1 - 5e-28 96.6 4.6 6.9e-28 96.1 4.6 1.2 1 0 0 1 1 1 1 Ribosomal protein S27 Mu-like_Com PF10122.9 CCF53551.1 - 0.0017 17.8 0.9 0.097 12.1 0.1 2.1 1 1 1 2 2 2 2 Mu-like prophage protein Com TF_Zn_Ribbon PF08271.12 CCF53551.1 - 0.011 15.2 0.4 0.019 14.4 0.4 1.4 1 0 0 1 1 1 0 TFIIB zinc-binding DUF1282 PF06930.12 CCF53551.1 - 0.18 11.6 0.0 0.18 11.6 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1282) zinc_ribbon_12 PF11331.8 CCF53551.1 - 0.2 11.5 4.1 2.5 8.0 2.7 2.5 1 1 1 2 2 2 0 Probable zinc-ribbon domain Ribosomal_L19e PF01280.20 CCF53552.1 - 4.3e-61 205.2 9.5 4.3e-61 205.2 9.5 1.6 2 0 0 2 2 2 1 Ribosomal protein L19e SGL PF08450.12 CCF53553.1 - 0.0085 15.7 0.0 0.015 14.9 0.0 1.3 1 0 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region Str_synth PF03088.16 CCF53553.1 - 0.013 15.6 0.0 0.04 14.0 0.0 1.8 2 0 0 2 2 2 0 Strictosidine synthase Arylesterase PF01731.20 CCF53553.1 - 0.062 13.5 0.0 0.43 10.8 0.0 2.1 2 0 0 2 2 2 0 Arylesterase MAGE_N PF12440.8 CCF53553.1 - 0.52 11.0 5.4 0.22 12.2 2.2 2.0 2 0 0 2 2 2 0 Melanoma associated antigen family N terminal Sugar_tr PF00083.24 CCF53555.1 - 5e-111 371.8 22.9 7.3e-111 371.2 22.9 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF53555.1 - 1.8e-27 96.2 36.0 1.6e-26 93.0 31.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Orai-1 PF07856.12 CCF53555.1 - 7.8 6.1 8.4 5.5 6.6 4.4 2.6 2 0 0 2 2 2 0 Mediator of CRAC channel activity Yippee-Mis18 PF03226.14 CCF53557.1 - 8.3e-16 58.1 0.1 9.4e-16 57.9 0.1 1.1 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly RIG-I_C-RD PF11648.8 CCF53557.1 - 0.024 14.9 0.4 0.036 14.3 0.4 1.4 1 1 0 1 1 1 0 C-terminal domain of RIG-I AARP2CN PF08142.12 CCF53557.1 - 0.12 12.5 0.0 0.23 11.6 0.0 1.5 2 0 0 2 2 2 0 AARP2CN (NUC121) domain TIM21 PF08294.11 CCF53558.1 - 6.1e-14 52.1 0.0 5e-10 39.4 0.0 2.4 2 1 0 2 2 2 2 TIM21 Transposase_23 PF03017.14 CCF53558.1 - 0.16 11.9 0.0 0.39 10.7 0.0 1.6 1 0 0 1 1 1 0 TNP1/EN/SPM transposase DPBB_1 PF03330.18 CCF53559.1 - 3.6e-05 24.0 0.0 6.1e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 Lytic transglycolase DUF4316 PF14195.6 CCF53560.1 - 0.044 13.5 0.1 0.08 12.7 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4316) FAM209 PF15206.6 CCF53560.1 - 0.17 11.6 1.7 0.29 10.9 1.7 1.4 1 0 0 1 1 1 0 FAM209 family RAP1 PF07218.11 CCF53560.1 - 5.5 5.2 4.5 6.1 5.0 4.5 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Citrate_synt PF00285.21 CCF53561.1 - 6.9e-95 318.2 0.0 8.8e-95 317.8 0.0 1.1 1 0 0 1 1 1 1 Citrate synthase, C-terminal domain WD40 PF00400.32 CCF53562.1 - 1.6e-09 38.2 0.3 0.37 11.8 0.0 5.4 5 1 0 5 5 5 3 WD domain, G-beta repeat Glyco_transf_41 PF13844.6 CCF53563.1 - 8.9e-107 357.4 1.4 4.7e-50 170.4 0.0 4.2 3 1 1 4 4 4 4 Glycosyl transferase family 41 TPR_1 PF00515.28 CCF53563.1 - 5.7e-21 73.4 0.0 7.6e-06 25.5 0.0 5.4 5 0 0 5 5 4 4 Tetratricopeptide repeat TPR_11 PF13414.6 CCF53563.1 - 7.4e-19 67.2 4.9 6e-06 25.8 0.1 6.1 3 2 3 6 6 6 4 TPR repeat TPR_17 PF13431.6 CCF53563.1 - 7.3e-17 60.5 6.4 0.002 18.4 0.0 6.0 6 0 0 6 6 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 CCF53563.1 - 3.6e-16 57.9 0.1 0.00064 19.7 0.0 6.3 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.6 CCF53563.1 - 1.2e-15 56.4 0.0 1e-06 28.4 0.0 4.9 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_10 PF13374.6 CCF53563.1 - 1.3e-12 47.1 14.7 0.00016 21.4 0.0 5.8 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_19 PF14559.6 CCF53563.1 - 5.8e-12 45.9 1.4 4.1e-05 24.0 0.2 5.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 CCF53563.1 - 2e-11 43.7 0.5 0.019 15.7 0.0 6.6 3 1 2 5 5 5 3 Tetratricopeptide repeat TPR_12 PF13424.6 CCF53563.1 - 4.8e-10 39.6 2.6 0.033 14.5 0.0 5.4 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.6 CCF53563.1 - 2.1e-08 33.6 0.0 0.17 12.0 0.0 5.0 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_9 PF13371.6 CCF53563.1 - 3.1e-05 24.0 0.6 0.011 15.9 0.0 3.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.6 CCF53563.1 - 4.7e-05 23.9 13.8 7e-05 23.4 0.0 5.4 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_6 PF13174.6 CCF53563.1 - 0.0077 16.8 0.1 6 7.7 0.0 4.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TEX19 PF15553.6 CCF53563.1 - 4.5 7.2 6.2 1.4 8.8 1.0 2.7 2 0 0 2 2 2 0 Testis-expressed protein 19 DnaJ PF00226.31 CCF53564.1 - 0.00017 21.7 0.0 0.00027 21.0 0.0 1.3 1 0 0 1 1 1 1 DnaJ domain Pam16 PF03656.13 CCF53564.1 - 0.0002 21.3 0.5 0.00037 20.5 0.0 1.6 2 0 0 2 2 2 1 Pam16 T2SSF PF00482.23 CCF53564.1 - 0.054 13.5 0.0 0.078 12.9 0.0 1.4 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein F Sec23_trunk PF04811.15 CCF53565.1 - 1.3e-77 260.7 0.0 1.8e-77 260.2 0.0 1.2 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_BS PF08033.12 CCF53565.1 - 2.4e-30 105.1 0.0 4.3e-30 104.3 0.0 1.4 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain Sec23_helical PF04815.15 CCF53565.1 - 4.3e-26 90.7 0.1 9.2e-26 89.7 0.1 1.6 1 0 0 1 1 1 1 Sec23/Sec24 helical domain zf-Sec23_Sec24 PF04810.15 CCF53565.1 - 7.2e-16 58.0 6.2 1.3e-15 57.1 6.2 1.5 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 CCF53565.1 - 8.8e-12 44.8 0.0 1.9e-11 43.7 0.0 1.5 1 0 0 1 1 1 1 Gelsolin repeat Vps36-NZF-N PF16988.5 CCF53565.1 - 0.11 11.9 0.1 0.23 10.9 0.1 1.4 1 0 0 1 1 1 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain Ribosomal_L28 PF00830.19 CCF53567.1 - 1.3e-20 73.3 0.5 2.2e-20 72.6 0.5 1.4 1 0 0 1 1 1 1 Ribosomal L28 family DUF3086 PF11285.8 CCF53567.1 - 0.032 13.3 0.0 0.041 13.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3086) Brix PF04427.18 CCF53568.1 - 8e-29 101.1 0.6 1e-28 100.7 0.6 1.1 1 0 0 1 1 1 1 Brix domain DUF4128 PF13554.6 CCF53568.1 - 0.064 13.3 0.0 0.14 12.2 0.0 1.6 1 0 0 1 1 1 0 Bacteriophage related domain of unknown function Wtap PF17098.5 CCF53568.1 - 0.11 12.5 0.1 0.17 11.8 0.1 1.4 1 0 0 1 1 1 0 WTAP/Mum2p family ATP-synt_ab PF00006.25 CCF53569.1 - 3.1e-66 223.1 0.0 4.2e-66 222.6 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 CCF53569.1 - 2.2e-13 50.5 0.3 4e-13 49.7 0.3 1.4 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain DUF3533 PF12051.8 CCF53569.1 - 0.00027 20.0 0.0 0.00047 19.2 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3533) DAO PF01266.24 CCF53570.1 - 2.4e-50 172.1 0.2 3.6e-50 171.5 0.2 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase DAO_C PF16901.5 CCF53570.1 - 4.3e-45 152.6 0.1 9.3e-45 151.6 0.1 1.6 1 0 0 1 1 1 1 C-terminal domain of alpha-glycerophosphate oxidase EF-hand_7 PF13499.6 CCF53570.1 - 3.4e-09 37.0 1.8 7.6e-09 35.9 1.8 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 CCF53570.1 - 3.8e-07 29.5 2.3 5.2e-05 22.9 0.3 2.7 2 0 0 2 2 2 1 EF-hand domain FAD_oxidored PF12831.7 CCF53570.1 - 1.5e-05 24.5 0.5 8.8e-05 22.0 0.2 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase EF-hand_8 PF13833.6 CCF53570.1 - 2.3e-05 24.2 1.3 0.0001 22.0 0.6 2.5 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_1 PF00036.32 CCF53570.1 - 7.5e-05 22.0 1.6 0.018 14.5 0.3 2.7 2 0 0 2 2 2 2 EF hand FAD_binding_3 PF01494.19 CCF53570.1 - 0.00043 19.6 0.3 0.0042 16.4 0.3 2.1 1 1 0 1 1 1 1 FAD binding domain FAD_binding_2 PF00890.24 CCF53570.1 - 0.00097 18.3 4.2 0.0038 16.4 4.2 2.0 1 1 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 CCF53570.1 - 0.0015 17.8 0.2 0.0047 16.2 0.0 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 CCF53570.1 - 0.0068 15.5 0.2 0.038 13.1 0.2 1.9 2 0 0 2 2 2 1 Glucose inhibited division protein A EF-hand_5 PF13202.6 CCF53570.1 - 0.014 14.9 0.6 0.036 13.6 0.6 1.8 1 0 0 1 1 1 0 EF hand Methyltransf_34 PF11312.8 CCF53570.1 - 0.028 13.7 0.2 0.77 8.9 0.0 2.2 2 0 0 2 2 2 0 Putative SAM-dependent methyltransferase 3HCDH_N PF02737.18 CCF53570.1 - 0.034 14.0 0.2 0.095 12.6 0.2 1.8 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_8 PF13450.6 CCF53570.1 - 0.067 13.4 0.5 0.31 11.3 0.4 2.2 2 0 0 2 2 1 0 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 CCF53570.1 - 0.089 12.0 0.0 0.19 10.9 0.0 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CCF53570.1 - 0.17 10.5 1.6 0.32 9.7 1.6 1.4 1 0 0 1 1 1 0 HI0933-like protein Pyr_redox PF00070.27 CCF53570.1 - 0.76 10.4 3.2 0.44 11.1 0.8 1.8 2 0 0 2 2 1 0 Pyridine nucleotide-disulphide oxidoreductase CarD_CdnL_TRCF PF02559.16 CCF53571.1 - 0.51 11.1 0.0 0.51 11.1 0.0 2.1 1 1 1 2 2 2 0 CarD-like/TRCF domain CALM_bind PF16025.5 CCF53571.1 - 0.75 10.3 7.9 1.6 9.3 7.9 1.6 1 1 0 1 1 1 0 Calcium-dependent calmodulin binding DUF1682 PF07946.14 CCF53571.1 - 3.5 6.8 13.6 5.2 6.2 13.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) RNA_polI_A34 PF08208.11 CCF53571.1 - 5.7 7.0 18.6 6.5 6.8 18.6 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 RR_TM4-6 PF06459.12 CCF53571.1 - 8.5 6.1 13.7 9.9 5.9 13.7 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 TPR_1 PF00515.28 CCF53572.1 - 1.6e-14 53.0 1.9 2.8e-06 26.9 0.0 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 CCF53572.1 - 9.4e-13 47.2 9.0 2.5e-05 24.0 0.1 4.0 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.6 CCF53572.1 - 3.8e-11 42.5 5.2 2.1e-07 30.5 0.5 3.3 3 0 0 3 3 3 2 TPR repeat RPAP3_C PF13877.6 CCF53572.1 - 8.9e-11 42.2 0.0 1.7e-10 41.3 0.0 1.4 1 0 0 1 1 1 1 Potential Monad-binding region of RPAP3 TPR_19 PF14559.6 CCF53572.1 - 3.5e-09 37.0 5.9 0.0014 19.1 0.8 4.3 4 1 1 5 5 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 CCF53572.1 - 2.4e-08 34.5 10.8 7e-05 23.4 3.0 3.5 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_9 PF13371.6 CCF53572.1 - 1.4e-07 31.5 0.6 0.00026 21.1 0.2 2.5 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 CCF53572.1 - 7.8e-07 29.4 4.9 0.00062 20.4 1.1 3.3 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 CCF53572.1 - 1.6e-06 28.1 0.4 0.23 11.9 0.0 3.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 CCF53572.1 - 2.8e-05 24.0 0.2 0.011 15.9 0.0 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 CCF53572.1 - 0.0013 18.9 1.1 0.069 13.4 0.0 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.6 CCF53572.1 - 0.002 18.0 2.1 1.1 9.4 0.2 4.1 3 1 1 4 4 4 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 CCF53572.1 - 0.005 16.9 0.3 1.3 9.2 0.0 2.5 1 1 1 2 2 2 1 Fis1 C-terminal tetratricopeptide repeat TPR_6 PF13174.6 CCF53572.1 - 0.11 13.2 7.0 0.81 10.5 0.2 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat Aminotran_1_2 PF00155.21 CCF53573.1 - 2.8e-37 128.8 0.0 5e-37 127.9 0.0 1.4 1 1 0 1 1 1 1 Aminotransferase class I and II Aminotran_MocR PF12897.7 CCF53573.1 - 0.00018 20.5 0.0 0.00027 19.9 0.0 1.2 1 0 0 1 1 1 1 Alanine-glyoxylate amino-transferase Beta_elim_lyase PF01212.21 CCF53573.1 - 0.00029 20.2 0.0 0.0005 19.4 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase Acetyltransf_1 PF00583.25 CCF53575.1 - 3.8e-16 59.4 0.0 5.2e-16 58.9 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 CCF53575.1 - 7.7e-10 39.1 0.0 1.1e-09 38.6 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CCF53575.1 - 9e-10 38.4 0.1 1.4e-09 37.8 0.1 1.2 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_10 PF13673.7 CCF53575.1 - 1.1e-09 38.3 0.0 1.6e-09 37.7 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 CCF53575.1 - 3.3e-06 26.9 0.0 4.4e-06 26.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 CCF53575.1 - 1.1e-05 25.5 0.0 1.5e-05 25.1 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 CCF53575.1 - 1.2e-05 26.0 0.0 1.5e-05 25.7 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 CCF53575.1 - 0.015 15.4 0.1 0.026 14.6 0.1 1.4 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase Acetyltransf_18 PF18014.1 CCF53575.1 - 0.017 15.0 0.0 0.028 14.2 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain GNAT_acetyltran PF12746.7 CCF53575.1 - 0.021 14.4 0.0 0.028 14.0 0.0 1.1 1 0 0 1 1 1 0 GNAT acetyltransferase Acetyltransf_15 PF17013.5 CCF53575.1 - 0.13 11.7 0.0 0.27 10.7 0.0 1.5 1 1 0 1 1 1 0 Putative acetyl-transferase CPP1-like PF11833.8 CCF53576.1 - 8.1 6.1 6.7 38 3.9 6.7 2.2 1 0 0 1 1 1 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like PCI PF01399.27 CCF53577.1 - 3.7e-05 24.2 0.0 8.2e-05 23.1 0.0 1.6 1 0 0 1 1 1 1 PCI domain RXT2_N PF08595.11 CCF53579.1 - 0.0046 17.0 1.1 0.0046 17.0 1.1 4.3 4 1 0 4 4 4 1 RXT2-like, N-terminal KilA-N PF04383.13 CCF53581.1 - 0.00086 19.1 0.0 0.002 18.0 0.0 1.5 1 1 0 1 1 1 1 KilA-N domain TFIIA PF03153.13 CCF53581.1 - 5 7.0 10.9 9.4 6.1 10.9 1.5 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Pkinase PF00069.25 CCF53582.1 - 1.9e-66 224.2 0.0 2.7e-66 223.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF53582.1 - 3.3e-46 157.7 0.0 5e-46 157.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCF53582.1 - 7.2e-08 32.1 0.0 2.7e-05 23.6 0.0 2.2 2 0 0 2 2 2 2 Kinase-like Ras_bdg_2 PF14847.6 CCF53582.1 - 0.0039 17.5 0.0 0.0091 16.3 0.0 1.5 1 0 0 1 1 1 1 Ras-binding domain of Byr2 Kdo PF06293.14 CCF53582.1 - 0.025 13.9 0.0 0.051 12.9 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CCF53582.1 - 0.055 13.4 0.0 0.2 11.5 0.0 2.1 1 0 0 1 1 1 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 CCF53582.1 - 0.076 11.9 0.0 0.14 11.1 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain LIM PF00412.22 CCF53583.1 - 4.6e-11 42.8 42.3 2.1e-10 40.6 3.0 4.6 5 0 0 5 5 5 3 LIM domain MCM PF00493.23 CCF53584.1 - 2.8e-100 334.0 0.0 4e-100 333.5 0.0 1.2 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 CCF53584.1 - 1.8e-37 128.0 0.0 3e-37 127.3 0.0 1.3 1 0 0 1 1 1 1 MCM OB domain MCM2_N PF12619.8 CCF53584.1 - 6.3e-32 111.0 24.2 6.3e-32 111.0 24.2 4.0 4 0 0 4 4 4 1 Mini-chromosome maintenance protein 2 MCM_lid PF17855.1 CCF53584.1 - 1.1e-25 89.9 1.7 4.7e-25 87.8 0.6 2.7 4 0 0 4 4 4 1 MCM AAA-lid domain MCM_N PF14551.6 CCF53584.1 - 2.4e-13 50.6 0.0 7.3e-13 49.0 0.0 1.8 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 CCF53584.1 - 1.5e-08 34.3 0.0 4.1e-07 29.6 0.0 2.3 1 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 CCF53584.1 - 1.7e-06 28.1 0.0 4.1e-06 26.8 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 CCF53584.1 - 1.5e-05 24.9 0.2 0.00025 20.9 0.0 2.6 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 CCF53584.1 - 0.012 15.3 0.1 0.094 12.4 0.1 2.1 1 1 0 1 1 1 0 Sigma-54 interaction domain AAA_lid_2 PF17863.1 CCF53584.1 - 0.053 13.4 1.4 0.25 11.2 0.3 2.5 2 0 0 2 2 2 0 AAA lid domain AAA PF00004.29 CCF53584.1 - 0.084 13.3 0.0 0.27 11.7 0.0 1.9 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) SelR PF01641.18 CCF53584.1 - 0.15 12.2 0.1 6.6 6.8 0.1 2.5 2 0 0 2 2 2 0 SelR domain polyprenyl_synt PF00348.17 CCF53585.1 - 3.7e-94 314.6 0.0 4.7e-94 314.2 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase Dynactin_p62 PF05502.13 CCF53586.1 - 1.3e-60 205.6 12.1 1.6e-41 142.6 5.0 2.9 2 1 0 2 2 2 2 Dynactin p62 family DUF4714 PF15833.5 CCF53587.1 - 0.29 11.1 1.5 0.36 10.8 0.5 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4714) Pkinase PF00069.25 CCF53588.1 - 9.7e-51 172.6 0.7 1.4e-30 106.5 0.1 3.5 3 1 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.17 CCF53588.1 - 1.1e-25 90.4 1.1 4.6e-21 75.3 0.1 4.1 4 0 0 4 4 4 3 Protein tyrosine kinase Pkinase_fungal PF17667.1 CCF53588.1 - 0.00013 20.9 0.0 0.00036 19.4 0.0 1.8 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 CCF53588.1 - 0.00043 19.7 0.2 0.64 9.3 0.0 2.9 3 0 0 3 3 3 2 Kinase-like XAP5 PF04921.14 CCF53588.1 - 0.015 15.1 0.1 0.031 14.1 0.1 1.5 1 0 0 1 1 1 0 XAP5, circadian clock regulator SLS PF14611.6 CCF53588.1 - 0.047 13.5 0.6 0.64 9.8 1.0 2.2 2 0 0 2 2 2 0 Mitochondrial inner-membrane-bound regulator Cyto_heme_lyase PF01265.17 CCF53589.1 - 1e-72 245.2 31.0 2.2e-58 198.2 11.6 3.6 1 1 1 2 2 2 2 Cytochrome c/c1 heme lyase SPX PF03105.19 CCF53589.1 - 1.9 8.3 9.6 3 7.7 9.6 1.3 1 0 0 1 1 1 0 SPX domain UbiA PF01040.18 CCF53590.1 - 1.5e-42 145.7 20.5 1.5e-42 145.7 20.5 2.6 2 1 0 2 2 2 1 UbiA prenyltransferase family MCU PF04678.13 CCF53590.1 - 7e-29 101.2 0.0 1.6e-28 100.0 0.0 1.6 1 0 0 1 1 1 1 Mitochondrial calcium uniporter CAF20 PF17052.5 CCF53590.1 - 1.9 8.7 16.8 0.11 12.6 10.1 2.3 2 1 0 2 2 2 0 Cap associated factor Brr6_like_C_C PF10104.9 CCF53592.1 - 6.1e-42 142.6 0.7 8.5e-42 142.1 0.7 1.2 1 0 0 1 1 1 1 Di-sulfide bridge nucleocytoplasmic transport domain DUF1461 PF07314.11 CCF53592.1 - 0.028 14.3 0.9 0.34 10.8 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1461) RXT2_N PF08595.11 CCF53592.1 - 0.044 13.8 0.9 0.091 12.8 0.9 1.6 1 0 0 1 1 1 0 RXT2-like, N-terminal Sporozoite_P67 PF05642.11 CCF53592.1 - 0.067 11.3 0.1 0.14 10.3 0.1 1.4 1 0 0 1 1 1 0 Sporozoite P67 surface antigen PBP1_TM PF14812.6 CCF53592.1 - 0.12 12.7 6.0 0.037 14.4 2.5 2.0 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal FAM176 PF14851.6 CCF53592.1 - 0.13 12.0 0.9 0.94 9.1 1.1 2.2 2 0 0 2 2 2 0 FAM176 family Nucleo_P87 PF07267.11 CCF53592.1 - 6.4 5.5 5.7 10 4.8 5.7 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 Y_phosphatase2 PF03162.13 CCF53593.1 - 5.6e-24 84.6 0.0 6.7e-15 55.0 0.0 2.4 2 0 0 2 2 2 2 Tyrosine phosphatase family Y_phosphatase PF00102.27 CCF53593.1 - 0.073 12.6 0.0 0.12 12.0 0.0 1.2 1 0 0 1 1 1 0 Protein-tyrosine phosphatase Nucleo_P87 PF07267.11 CCF53593.1 - 0.85 8.4 19.7 1.8 7.3 19.7 1.6 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 BUD22 PF09073.10 CCF53593.1 - 2.4 7.4 38.6 5.8 6.1 38.6 1.6 1 0 0 1 1 1 0 BUD22 Nop14 PF04147.12 CCF53593.1 - 4.7 5.3 47.4 8.5 4.5 47.4 1.4 1 0 0 1 1 1 0 Nop14-like family AIP3 PF03915.13 CCF53594.1 - 1.9e-139 465.3 0.5 3e-139 464.7 0.5 1.3 1 0 0 1 1 1 1 Actin interacting protein 3 RIF5_SNase_2 PF18189.1 CCF53594.1 - 0.12 12.2 0.2 0.26 11.1 0.2 1.5 1 0 0 1 1 1 0 TbRIF5 SNase domain 2 CHDCT2 PF08074.11 CCF53594.1 - 0.15 12.3 0.3 1.3 9.1 0.0 2.6 1 1 2 3 3 3 0 CHDCT2 (NUC038) domain DUF383 PF04063.14 CCF53595.1 - 4.6e-60 202.6 0.0 1.4e-59 201.0 0.0 1.9 1 1 0 1 1 1 1 Domain of unknown function (DUF383) DUF384 PF04064.13 CCF53595.1 - 3e-16 59.0 0.3 7.2e-16 57.8 0.3 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF384) HEAT PF02985.22 CCF53595.1 - 0.036 14.3 2.9 0.18 12.1 0.0 3.5 4 0 0 4 4 4 0 HEAT repeat DUF4665 PF15679.5 CCF53595.1 - 0.99 10.1 7.0 0.21 12.2 2.9 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4665) Zn_clus PF00172.18 CCF53596.1 - 5.2e-09 36.1 10.2 1e-08 35.1 10.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain HMG_box PF00505.19 CCF53597.1 - 3.8e-10 40.0 3.4 3.8e-10 40.0 3.4 2.7 2 1 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.10 CCF53597.1 - 0.044 14.4 0.7 0.18 12.5 0.7 2.1 1 0 0 1 1 1 0 HMG-box domain DNA_pol_B PF00136.21 CCF53598.1 - 1.2e-149 499.0 0.7 1.6e-149 498.6 0.7 1.2 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 CCF53598.1 - 6e-88 295.2 0.0 1.1e-87 294.4 0.0 1.5 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.6 CCF53598.1 - 1.2e-16 60.9 8.1 2.6e-16 59.9 8.1 1.6 1 0 0 1 1 1 1 C4-type zinc-finger of DNA polymerase delta DNA_pol_B_2 PF03175.13 CCF53598.1 - 0.0041 16.0 0.4 0.011 14.6 0.0 2.0 2 0 0 2 2 2 1 DNA polymerase type B, organellar and viral AMP-binding PF00501.28 CCF53599.1 - 1.1e-85 287.9 0.0 1.8e-85 287.1 0.0 1.3 2 0 0 2 2 2 1 AMP-binding enzyme AMP-binding_C PF13193.6 CCF53599.1 - 4.3e-14 53.2 0.4 9.8e-14 52.1 0.4 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain GH3 PF03321.13 CCF53599.1 - 5.8e-05 22.1 0.0 0.021 13.7 0.0 2.2 2 0 0 2 2 2 2 GH3 auxin-responsive promoter Methyltr_RsmB-F PF01189.17 CCF53600.1 - 1.1e-73 247.1 0.0 1.8e-73 246.5 0.0 1.3 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Methyltr_RsmF_N PF17125.5 CCF53600.1 - 3.4e-08 33.9 0.0 9.6e-08 32.4 0.0 1.8 1 0 0 1 1 1 1 N-terminal domain of 16S rRNA methyltransferase RsmF Met_10 PF02475.16 CCF53600.1 - 0.00064 19.5 0.0 0.0013 18.5 0.0 1.5 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_31 PF13847.6 CCF53600.1 - 0.0068 16.2 0.0 0.014 15.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 CCF53600.1 - 0.0081 15.9 0.0 0.015 15.0 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) FtsJ PF01728.19 CCF53600.1 - 0.0087 16.2 0.0 0.025 14.7 0.0 1.7 1 0 0 1 1 1 1 FtsJ-like methyltransferase DUF2431 PF10354.9 CCF53600.1 - 0.11 12.8 0.0 0.2 11.9 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF2431) Macoilin PF09726.9 CCF53600.1 - 4.6 5.7 8.5 8.6 4.8 8.5 1.4 1 0 0 1 1 1 0 Macoilin family Nucleo_P87 PF07267.11 CCF53600.1 - 6 5.6 12.9 13 4.5 12.9 1.5 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 Acyl-CoA_dh_1 PF00441.24 CCF53601.1 - 4.3e-31 108.2 0.3 7e-31 107.5 0.3 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 CCF53601.1 - 3.8e-16 59.1 0.5 7.7e-16 58.1 0.5 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Cyt-b5 PF00173.28 CCF53601.1 - 9.4e-16 57.7 0.0 2.2e-15 56.5 0.0 1.6 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Acyl-CoA_dh_N PF02771.16 CCF53601.1 - 2e-15 57.4 0.0 2.5e-14 53.9 0.0 2.5 2 1 1 3 3 3 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 CCF53601.1 - 1.3e-07 32.0 0.4 2.9e-07 30.8 0.0 1.7 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain HpaB_N PF11794.8 CCF53601.1 - 0.023 14.3 0.0 0.038 13.7 0.0 1.3 1 0 0 1 1 1 0 4-hydroxyphenylacetate 3-hydroxylase N terminal Stealth_CR2 PF11380.8 CCF53602.1 - 5.2e-10 39.5 0.9 1.6e-06 28.2 0.1 3.5 2 1 1 3 3 3 2 Stealth protein CR2, conserved region 2 Stealth_CR3 PF17102.5 CCF53602.1 - 2.7e-08 33.6 0.2 5.7e-08 32.5 0.2 1.6 1 0 0 1 1 1 1 Stealth protein CR3, conserved region 3 Stealth_CR1 PF17101.5 CCF53602.1 - 2.1e-05 24.2 0.0 4.4e-05 23.1 0.0 1.5 1 0 0 1 1 1 1 Stealth protein CR1, conserved region 1 Stealth_CR4 PF17103.5 CCF53602.1 - 5.2e-05 23.1 0.7 0.00017 21.4 0.0 2.2 3 0 0 3 3 3 1 Stealth protein CR4, conserved region 4 Nexin_C PF08628.12 CCF53603.1 - 5.1e-17 62.5 0.1 3.2e-16 59.9 0.0 2.4 2 0 0 2 2 2 1 Sorting nexin C terminal PXA PF02194.15 CCF53603.1 - 4.9e-15 56.0 2.2 6.4e-14 52.3 0.5 2.7 2 0 0 2 2 2 1 PXA domain DUF2273 PF10031.9 CCF53603.1 - 0.65 10.0 2.6 1.3 9.1 2.6 1.5 1 0 0 1 1 1 0 Small integral membrane protein (DUF2273) EIF_2_alpha PF07541.12 CCF53604.1 - 3.3e-36 123.9 0.2 7.3e-36 122.8 0.0 1.7 2 0 0 2 2 2 1 Eukaryotic translation initiation factor 2 alpha subunit S1 PF00575.23 CCF53604.1 - 7.2e-15 55.1 0.6 2.6e-14 53.3 0.6 2.0 1 0 0 1 1 1 1 S1 RNA binding domain EXOSC1 PF10447.9 CCF53604.1 - 0.016 15.8 1.1 2.7 8.6 0.1 3.2 2 1 1 3 3 3 0 Exosome component EXOSC1/CSL4 DUF4453 PF14627.6 CCF53604.1 - 0.031 14.4 0.0 0.06 13.5 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4453) Ank_4 PF13637.6 CCF53605.1 - 0.0012 19.4 0.3 0.0046 17.5 0.1 2.1 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 CCF53605.1 - 0.0029 18.1 0.0 0.0063 17.1 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Phage_T7_tail PF03906.14 CCF53605.1 - 0.0032 17.2 0.0 0.006 16.3 0.0 1.4 1 0 0 1 1 1 1 Phage T7 tail fibre protein Ank_3 PF13606.6 CCF53605.1 - 0.009 16.5 0.3 16 6.4 0.1 3.5 4 0 0 4 4 4 2 Ankyrin repeat Ank PF00023.30 CCF53605.1 - 0.087 13.3 0.2 19 5.9 0.0 2.7 2 0 0 2 2 2 0 Ankyrin repeat CDC45 PF02724.14 CCF53605.1 - 0.25 9.6 9.6 0.12 10.7 5.6 1.9 2 0 0 2 2 2 0 CDC45-like protein Zip PF02535.22 CCF53605.1 - 0.66 9.1 4.1 9.1 5.4 3.6 2.1 2 0 0 2 2 2 0 ZIP Zinc transporter Trehalase PF01204.18 CCF53606.1 - 2.6e-173 577.5 0.0 3.3e-173 577.2 0.0 1.1 1 0 0 1 1 1 1 Trehalase Trehalase_Ca-bi PF07492.11 CCF53606.1 - 1.2e-15 56.9 0.2 2.3e-15 56.0 0.2 1.5 1 0 0 1 1 1 1 Neutral trehalase Ca2+ binding domain Carn_acyltransf PF00755.20 CCF53607.1 - 2.9e-173 577.7 0.0 3.4e-173 577.5 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase tRNA-synt_1d PF00750.19 CCF53608.1 - 4.6e-99 331.7 2.5 6.1e-99 331.3 2.5 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (R) DALR_1 PF05746.15 CCF53608.1 - 6.6e-22 77.9 1.3 5.8e-21 74.9 0.0 2.8 3 0 0 3 3 3 1 DALR anticodon binding domain POT1 PF02765.17 CCF53608.1 - 0.0004 20.2 0.1 0.0087 15.9 0.0 2.2 2 0 0 2 2 2 1 Telomeric single stranded DNA binding POT1/CDC13 WaaY PF06176.11 CCF53608.1 - 0.065 12.8 0.0 0.32 10.6 0.0 2.0 2 0 0 2 2 2 0 Lipopolysaccharide core biosynthesis protein (WaaY) JIP_LZII PF16471.5 CCF53609.1 - 0.25 11.6 6.4 2.2 8.5 0.1 3.3 3 0 0 3 3 3 0 JNK-interacting protein leucine zipper II UPF0242 PF06785.11 CCF53609.1 - 0.33 11.0 21.0 10 6.2 0.3 3.1 2 1 1 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus DivIC PF04977.15 CCF53609.1 - 0.36 10.6 13.8 1.8 8.4 1.4 3.7 1 1 2 3 3 3 0 Septum formation initiator Med9 PF07544.13 CCF53609.1 - 2.3 8.4 12.5 0.64 10.1 2.8 3.2 2 1 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 Spc7 PF08317.11 CCF53609.1 - 6.5 5.5 21.5 0.42 9.5 11.3 2.5 1 1 0 2 2 2 0 Spc7 kinetochore protein Tti2 PF10521.9 CCF53610.1 - 2e-24 86.6 0.4 1.6e-17 64.0 0.0 2.7 3 0 0 3 3 3 2 Tti2 family MRP_L53 PF10780.9 CCF53611.1 - 0.0002 21.5 0.0 0.00032 20.8 0.0 1.4 1 0 0 1 1 1 1 39S ribosomal protein L53/MRP-L53 CPSF73-100_C PF11718.8 CCF53612.1 - 1.1e-53 182.1 5.1 3.4e-53 180.4 5.1 1.9 1 1 0 1 1 1 1 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term Beta-Casp PF10996.8 CCF53612.1 - 6.9e-29 100.4 0.0 1.8e-28 99.0 0.0 1.7 1 0 0 1 1 1 1 Beta-Casp domain Lactamase_B PF00753.27 CCF53612.1 - 1.1e-20 74.5 2.1 1.1e-20 74.5 2.1 2.3 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily Lactamase_B_6 PF16661.5 CCF53612.1 - 3.8e-20 72.2 0.0 9.6e-20 70.8 0.0 1.7 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain RMMBL PF07521.12 CCF53612.1 - 1.9e-16 59.7 0.1 4e-16 58.7 0.1 1.6 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B_3 PF13483.6 CCF53612.1 - 2.2e-08 34.2 1.3 8.4e-08 32.3 0.0 2.4 2 0 0 2 2 2 1 Beta-lactamase superfamily domain Lactamase_B_2 PF12706.7 CCF53612.1 - 9.1e-08 31.8 2.3 9.1e-08 31.8 2.3 2.5 3 0 0 3 3 3 1 Beta-lactamase superfamily domain SelP_N PF04592.14 CCF53612.1 - 5.9 6.2 12.6 14 5.0 12.6 1.6 1 0 0 1 1 1 0 Selenoprotein P, N terminal region RabGAP-TBC PF00566.18 CCF53613.1 - 1.1e-52 178.9 0.0 1.7e-52 178.2 0.0 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain GST_N_2 PF13409.6 CCF53614.1 - 7.8e-16 58.1 0.0 1.7e-15 57.1 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 CCF53614.1 - 3e-12 46.4 0.0 6.1e-12 45.4 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 CCF53614.1 - 5.8e-06 26.4 0.0 1e-05 25.7 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 CCF53614.1 - 6.3e-05 23.1 0.0 0.00012 22.2 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain F-box-like PF12937.7 CCF53615.1 - 0.047 13.6 0.3 0.11 12.3 0.3 1.7 1 0 0 1 1 1 0 F-box-like GCP_N_terminal PF17681.1 CCF53616.1 - 2.4e-65 221.2 0.0 3.7e-65 220.6 0.0 1.3 1 0 0 1 1 1 1 Gamma tubulin complex component N-terminal GCP_C_terminal PF04130.13 CCF53616.1 - 9.4e-37 127.1 6.8 1.5e-36 126.5 6.8 1.3 1 0 0 1 1 1 1 Gamma tubulin complex component C-terminal Syja_N PF02383.18 CCF53616.1 - 0.27 10.5 1.3 0.63 9.3 0.0 2.1 2 1 0 2 2 2 0 SacI homology domain DEK_C PF08766.11 CCF53617.1 - 8.1e-12 44.9 0.3 2.3e-11 43.4 0.3 1.9 1 0 0 1 1 1 1 DEK C terminal domain Sugar_tr PF00083.24 CCF53618.1 - 4.2e-98 329.1 20.3 4.9e-98 328.9 20.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF53618.1 - 3.5e-22 78.8 26.8 4.2e-19 68.7 16.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily WD40 PF00400.32 CCF53619.1 - 7.2e-20 70.9 12.4 0.0011 19.7 0.1 7.4 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF53619.1 - 9.7e-05 22.6 0.0 2.7 8.3 0.0 4.0 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.6 CCF53619.1 - 0.00015 21.4 2.6 0.00058 19.5 0.7 2.3 2 0 0 2 2 2 1 PQQ-like domain LysM PF01476.20 CCF53619.1 - 0.021 14.9 0.0 0.052 13.6 0.0 1.8 1 0 0 1 1 1 0 LysM domain WD40_like PF17005.5 CCF53619.1 - 0.16 11.3 0.0 0.53 9.6 0.0 1.8 1 1 0 1 1 1 0 WD40-like domain PQQ PF01011.21 CCF53619.1 - 0.21 11.6 1.1 73 3.6 0.0 4.0 4 0 0 4 4 4 0 PQQ enzyme repeat zf-UDP PF14569.6 CCF53619.1 - 0.56 10.4 2.6 1.7 8.8 2.6 1.8 1 0 0 1 1 1 0 Zinc-binding RING-finger DZR PF12773.7 CCF53619.1 - 1.2 9.2 9.3 2.6 8.1 9.3 1.5 1 0 0 1 1 1 0 Double zinc ribbon zf-RING_10 PF16685.5 CCF53619.1 - 1.8 8.7 6.2 4.2 7.6 6.2 1.5 1 0 0 1 1 1 0 zinc RING finger of MSL2 zf-C3HC4_3 PF13920.6 CCF53619.1 - 4.5 7.2 8.3 9.2 6.2 8.3 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) LRR_4 PF12799.7 CCF53620.1 - 8.7e-32 108.6 26.1 2.4e-09 37.3 1.9 7.0 2 2 3 8 8 8 7 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 CCF53620.1 - 3.5e-20 71.5 25.9 1.2e-07 31.3 5.8 6.1 2 1 4 7 7 7 5 Leucine rich repeat LRR_9 PF14580.6 CCF53620.1 - 2.3e-17 63.0 10.5 1.6e-07 31.0 0.4 4.8 1 1 3 4 4 4 4 Leucine-rich repeat LRR_6 PF13516.6 CCF53620.1 - 1.1e-06 28.2 16.2 0.62 10.3 0.2 8.3 8 1 2 10 10 10 3 Leucine Rich repeat LRR_1 PF00560.33 CCF53620.1 - 4.7e-06 26.4 25.2 4.2 8.3 0.5 9.5 10 0 0 10 10 10 2 Leucine Rich Repeat FA_hydroxylase PF04116.13 CCF53621.1 - 2.9e-19 69.7 18.8 2.9e-19 69.7 18.8 1.8 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily Peptidase_M16 PF00675.20 CCF53622.1 - 2.8e-19 69.5 0.3 1.5e-18 67.2 0.1 2.1 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 CCF53622.1 - 2.1e-12 47.4 0.0 6.4e-12 45.9 0.0 1.8 2 0 0 2 2 2 1 Peptidase M16 inactive domain Sad1_UNC PF07738.13 CCF53623.1 - 0.0032 17.5 0.0 0.93 9.5 0.1 2.6 1 1 1 2 2 2 2 Sad1 / UNC-like C-terminal CorA PF01544.18 CCF53623.1 - 0.005 16.2 4.7 0.011 15.1 4.0 1.9 2 0 0 2 2 2 1 CorA-like Mg2+ transporter protein HALZ PF02183.18 CCF53623.1 - 0.012 15.9 0.7 0.032 14.4 0.7 1.8 1 0 0 1 1 1 0 Homeobox associated leucine zipper Baculo_PEP_C PF04513.12 CCF53623.1 - 0.09 12.8 5.3 0.49 10.4 1.6 2.6 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus EcsC PF12787.7 CCF53623.1 - 0.51 10.0 3.8 11 5.6 0.1 3.3 3 1 0 3 3 3 0 EcsC protein family DraK_HK_N PF18092.1 CCF53623.1 - 4.1 7.9 9.9 7.7 7.0 0.6 3.3 2 1 1 3 3 3 0 DraK Histidine Kinase N-terminal domain DUF4407 PF14362.6 CCF53623.1 - 7.7 5.8 18.6 5.1 6.4 3.9 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) ATP_bind_1 PF03029.17 CCF53624.1 - 3.9e-72 242.9 1.2 1.8e-65 221.1 0.0 2.6 3 0 0 3 3 3 2 Conserved hypothetical ATP binding protein GTP_EFTU PF00009.27 CCF53624.1 - 1.7e-08 34.3 0.2 7.4e-07 28.9 0.2 2.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 CCF53624.1 - 0.0002 21.4 0.0 0.002 18.2 0.0 2.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_22 PF13401.6 CCF53624.1 - 0.001 19.4 0.1 0.0044 17.3 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 CCF53624.1 - 0.0011 19.4 0.7 0.0028 18.1 0.1 2.1 1 1 0 2 2 2 1 AAA ATPase domain MeaB PF03308.16 CCF53624.1 - 0.0014 17.7 0.4 0.12 11.4 0.0 2.4 2 1 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB FeoB_N PF02421.18 CCF53624.1 - 0.0018 17.8 0.0 0.0066 16.0 0.0 1.9 2 0 0 2 2 2 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 CCF53624.1 - 0.0019 18.1 0.3 0.76 9.7 0.1 3.0 3 0 0 3 3 3 1 RsgA GTPase G-alpha PF00503.20 CCF53624.1 - 0.0051 16.0 0.9 0.17 11.0 0.0 2.4 2 1 0 2 2 2 1 G-protein alpha subunit NTPase_1 PF03266.15 CCF53624.1 - 0.0064 16.4 0.0 5.2 7.0 0.0 2.6 3 0 0 3 3 3 1 NTPase Septin PF00735.18 CCF53624.1 - 0.0066 15.8 0.2 0.014 14.7 0.0 1.6 2 0 0 2 2 2 1 Septin FbpA PF05833.11 CCF53624.1 - 0.0074 15.1 0.2 0.0074 15.1 0.2 1.5 2 0 0 2 2 2 1 Fibronectin-binding protein A N-terminus (FbpA) NACHT PF05729.12 CCF53624.1 - 0.0084 16.0 0.0 0.017 15.1 0.0 1.5 1 0 0 1 1 1 1 NACHT domain AAA_18 PF13238.6 CCF53624.1 - 0.011 16.3 0.8 0.024 15.2 0.0 2.1 3 0 0 3 3 1 0 AAA domain AAA_25 PF13481.6 CCF53624.1 - 0.012 15.2 0.5 0.46 10.0 0.0 2.6 3 0 0 3 3 3 0 AAA domain SRP54 PF00448.22 CCF53624.1 - 0.014 15.1 0.1 0.27 10.8 0.0 2.4 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain ABC_tran PF00005.27 CCF53624.1 - 0.017 15.6 0.0 0.042 14.4 0.0 1.7 1 0 0 1 1 1 0 ABC transporter AAA_33 PF13671.6 CCF53624.1 - 0.019 15.1 0.7 0.019 15.1 0.7 3.0 3 1 0 3 3 2 0 AAA domain RNA_helicase PF00910.22 CCF53624.1 - 0.027 14.8 0.0 0.08 13.3 0.0 1.8 1 0 0 1 1 1 0 RNA helicase DUF463 PF04317.12 CCF53624.1 - 0.044 12.7 0.2 0.044 12.7 0.2 1.8 3 0 0 3 3 3 0 YcjX-like family, DUF463 NB-ARC PF00931.22 CCF53624.1 - 0.046 12.9 0.0 0.1 11.7 0.0 1.6 1 0 0 1 1 1 0 NB-ARC domain Tma16 PF11176.8 CCF53624.1 - 0.056 13.3 1.9 0.19 11.6 0.1 2.2 2 0 0 2 2 2 0 Translation machinery-associated protein 16 Viral_helicase1 PF01443.18 CCF53624.1 - 0.076 12.7 0.0 0.14 11.9 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase Ploopntkinase3 PF18751.1 CCF53624.1 - 0.088 12.7 0.0 0.2 11.5 0.0 1.5 1 0 0 1 1 1 0 P-loop Nucleotide Kinase3 PPV_E1_C PF00519.17 CCF53624.1 - 0.1 11.4 0.0 0.16 10.7 0.0 1.2 1 0 0 1 1 1 0 Papillomavirus helicase DUF87 PF01935.17 CCF53624.1 - 0.11 12.6 3.5 0.14 12.2 0.2 2.4 2 1 1 3 3 3 0 Helicase HerA, central domain Use1 PF09753.9 CCF53624.1 - 0.11 12.2 3.1 0.46 10.2 0.7 2.1 2 0 0 2 2 2 0 Membrane fusion protein Use1 PduV-EutP PF10662.9 CCF53624.1 - 0.21 11.3 0.8 1.2 8.8 0.1 2.4 2 1 1 3 3 3 0 Ethanolamine utilisation - propanediol utilisation Thymidylate_kin PF02223.17 CCF53624.1 - 0.34 10.6 2.7 1.4 8.5 0.1 2.3 2 0 0 2 2 2 0 Thymidylate kinase AAA_24 PF13479.6 CCF53624.1 - 0.84 9.3 4.0 18 5.0 4.0 2.8 1 1 0 1 1 1 0 AAA domain Roughex PF06020.11 CCF53624.1 - 1.8 7.6 4.9 0.34 10.0 1.0 1.6 2 0 0 2 2 2 0 Drosophila roughex protein Zn_clus PF00172.18 CCF53625.1 - 1.9e-06 27.9 9.5 3.6e-06 27.0 9.5 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain UMP1 PF05348.11 CCF53626.1 - 2.4e-36 124.6 0.5 3.1e-36 124.2 0.5 1.2 1 0 0 1 1 1 1 Proteasome maturation factor UMP1 T6SS_VipA PF05591.12 CCF53626.1 - 0.17 11.7 0.1 7.5 6.3 0.0 2.2 2 0 0 2 2 2 0 Type VI secretion system, VipA, VC_A0107 or Hcp2 rRNA_proc-arch PF13234.6 CCF53627.1 - 1.3e-84 284.3 0.0 2.1e-84 283.6 0.0 1.3 1 0 0 1 1 1 1 rRNA-processing arch domain DSHCT PF08148.12 CCF53627.1 - 7e-55 185.1 0.6 2e-54 183.7 0.6 1.8 1 0 0 1 1 1 1 DSHCT (NUC185) domain DEAD PF00270.29 CCF53627.1 - 1.1e-19 70.9 0.1 5.1e-18 65.4 0.0 3.1 3 0 0 3 3 3 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CCF53627.1 - 1.4e-06 28.6 0.0 6.5e-06 26.5 0.0 2.1 1 1 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 CCF53627.1 - 0.00065 19.7 0.0 0.0018 18.3 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit T2SSE PF00437.20 CCF53627.1 - 0.14 11.2 0.0 0.67 9.0 0.0 2.0 2 0 0 2 2 2 0 Type II/IV secretion system protein TLP-20 PF06088.11 CCF53627.1 - 3.2 7.6 7.6 8.7 6.2 7.6 1.7 1 0 0 1 1 1 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) CENP-F_leu_zip PF10473.9 CCF53627.1 - 4.1 7.4 6.7 0.7 9.9 1.9 2.1 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 MAJIN PF15077.6 CCF53627.1 - 4.9 6.9 5.3 9.9 5.9 5.3 1.4 1 0 0 1 1 1 0 Membrane-anchored junction protein ORC6 PF05460.13 CCF53627.1 - 6.3 6.0 12.1 12 5.0 12.1 1.4 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) NPR3 PF03666.13 CCF53627.1 - 8.7 5.0 7.8 13 4.4 7.8 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 5_nucleotid_C PF02872.18 CCF53628.1 - 5.7e-28 98.1 0.0 7.9e-21 74.9 0.0 2.4 2 0 0 2 2 2 2 5'-nucleotidase, C-terminal domain Metallophos PF00149.28 CCF53628.1 - 7e-07 30.0 0.1 1.3e-06 29.1 0.1 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Med9 PF07544.13 CCF53628.1 - 1.5e-05 25.0 1.9 3.7e-05 23.7 0.1 2.5 3 0 0 3 3 3 1 RNA polymerase II transcription mediator complex subunit 9 Syntaxin-6_N PF09177.11 CCF53629.1 - 1e-18 67.7 2.1 5.3e-18 65.4 0.2 2.3 2 1 0 2 2 2 1 Syntaxin 6, N-terminal Use1 PF09753.9 CCF53629.1 - 1.2e-05 25.2 0.7 2.1e-05 24.4 0.7 1.5 1 1 0 1 1 1 1 Membrane fusion protein Use1 SNARE PF05739.19 CCF53629.1 - 0.00019 21.4 6.4 0.00019 21.4 6.4 3.2 4 1 0 4 4 3 1 SNARE domain FliJ PF02050.16 CCF53629.1 - 0.00034 20.8 3.9 1.7 8.9 0.8 3.2 2 1 1 3 3 3 2 Flagellar FliJ protein DUF3584 PF12128.8 CCF53629.1 - 0.0055 14.3 4.4 0.0067 14.0 4.4 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) DUF745 PF05335.13 CCF53629.1 - 0.0071 16.1 2.4 0.54 9.9 0.3 2.2 1 1 1 2 2 2 2 Protein of unknown function (DUF745) Spc7 PF08317.11 CCF53629.1 - 0.01 14.7 3.6 0.024 13.6 2.2 1.9 1 1 1 2 2 2 0 Spc7 kinetochore protein Uso1_p115_C PF04871.13 CCF53629.1 - 0.023 15.1 5.1 0.14 12.5 0.1 2.8 2 1 0 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region FlaC_arch PF05377.11 CCF53629.1 - 0.027 14.9 1.9 13 6.2 0.0 3.9 3 1 0 3 3 3 0 Flagella accessory protein C (FlaC) DUF4810 PF16068.5 CCF53629.1 - 0.034 14.7 0.3 0.51 10.9 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4810) Spectrin PF00435.21 CCF53629.1 - 0.041 14.4 1.2 12 6.4 0.0 3.3 2 1 2 4 4 4 0 Spectrin repeat DUF2959 PF11172.8 CCF53629.1 - 0.079 13.1 4.6 0.67 10.1 0.5 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF2959) APG17 PF04108.12 CCF53629.1 - 0.13 11.4 6.2 0.73 8.9 0.6 2.1 1 1 0 2 2 2 0 Autophagy protein Apg17 AAA_13 PF13166.6 CCF53629.1 - 0.13 10.9 2.9 1.4 7.5 2.8 2.4 1 1 0 1 1 1 0 AAA domain DUF1664 PF07889.12 CCF53629.1 - 0.19 11.7 5.6 5.3 7.1 1.0 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) I_LWEQ PF01608.17 CCF53629.1 - 0.2 11.9 6.0 0.14 12.4 1.0 2.3 1 1 2 3 3 3 0 I/LWEQ domain TPR_MLP1_2 PF07926.12 CCF53629.1 - 0.25 11.4 5.7 0.35 10.9 0.8 2.9 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein DUF883 PF05957.13 CCF53629.1 - 0.37 11.4 2.2 1.8 9.3 0.4 2.8 2 2 0 2 2 2 0 Bacterial protein of unknown function (DUF883) TMF_TATA_bd PF12325.8 CCF53629.1 - 0.89 9.8 5.9 10 6.4 0.2 3.4 3 2 0 3 3 3 0 TATA element modulatory factor 1 TATA binding CENP-H PF05837.12 CCF53629.1 - 2 8.9 5.9 1.2 9.5 0.1 2.8 1 1 3 4 4 4 0 Centromere protein H (CENP-H) GlcV_C_terminal PF17847.1 CCF53631.1 - 0.055 13.9 0.0 0.093 13.2 0.0 1.3 1 0 0 1 1 1 0 Glucose ABC transporter C-terminal domain PPTA PF01239.22 CCF53632.1 - 5e-37 124.6 13.7 7.6e-10 38.2 0.1 5.6 5 0 0 5 5 5 5 Protein prenyltransferase alpha subunit repeat TPR_17 PF13431.6 CCF53632.1 - 0.019 15.3 1.7 2.3 8.8 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat BolA PF01722.18 CCF53633.1 - 1.3e-25 89.4 0.3 3e-25 88.3 0.3 1.6 1 0 0 1 1 1 1 BolA-like protein Ribosomal_L9_N PF01281.19 CCF53633.1 - 2.5e-10 39.8 0.0 4.6e-10 38.9 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L9, N-terminal domain polyprenyl_synt PF00348.17 CCF53634.1 - 3.3e-62 209.9 0.0 4e-55 186.6 0.0 2.7 2 1 0 2 2 2 2 Polyprenyl synthetase RAP1 PF07218.11 CCF53634.1 - 1.3 7.3 12.7 2 6.6 12.7 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) MRI PF15325.6 CCF53634.1 - 9.4 7.4 8.4 2.7 9.1 4.2 2.3 2 0 0 2 2 2 0 Modulator of retrovirus infection rhaM PF05336.13 CCF53635.1 - 2.6e-15 56.4 0.0 3e-15 56.2 0.0 1.0 1 0 0 1 1 1 1 L-rhamnose mutarotase Pkinase PF00069.25 CCF53636.1 - 5e-59 199.8 0.0 6.1e-39 134.0 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CCF53636.1 - 1.2e-25 90.3 0.0 3.4e-20 72.4 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Response_reg PF00072.24 CCF53636.1 - 1.4e-08 34.8 0.0 3e-08 33.8 0.0 1.6 1 0 0 1 1 1 1 Response regulator receiver domain Kinase-like PF14531.6 CCF53636.1 - 8.2e-08 31.9 0.1 3.9e-05 23.1 0.0 2.5 2 0 0 2 2 2 2 Kinase-like APH PF01636.23 CCF53636.1 - 0.0043 17.0 7.2 0.008 16.1 0.2 3.7 3 1 1 4 4 4 1 Phosphotransferase enzyme family Kdo PF06293.14 CCF53636.1 - 0.021 14.2 0.0 0.061 12.7 0.0 1.7 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family PAS_9 PF13426.7 CCF53636.1 - 0.023 14.9 0.0 0.071 13.4 0.0 1.8 1 0 0 1 1 1 0 PAS domain Seadorna_VP7 PF07387.11 CCF53636.1 - 0.12 11.4 0.1 0.2 10.7 0.1 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 FTA2 PF13095.6 CCF53636.1 - 0.15 11.7 0.0 23 4.5 0.0 2.4 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Gly_transf_sug PF04488.15 CCF53637.1 - 1.8e-19 70.2 0.0 3.4e-19 69.3 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif TcdA_TcdB PF12919.7 CCF53637.1 - 0.62 9.3 1.2 0.85 8.8 0.3 1.6 2 0 0 2 2 2 0 TcdA/TcdB catalytic glycosyltransferase domain Mito_carr PF00153.27 CCF53638.1 - 8.4e-75 246.8 0.5 6.2e-26 90.2 0.0 3.9 3 1 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 CCF53638.1 - 0.005 16.0 1.4 0.078 12.1 0.0 3.2 2 1 1 4 4 4 1 Gammaproteobacterial serine protease PrcB_C PF14343.6 CCF53638.1 - 0.12 12.5 0.2 84 3.4 0.0 3.6 3 0 0 3 3 3 0 PrcB C-terminal Amidase PF01425.21 CCF53639.1 - 1.5e-99 334.0 0.0 2.7e-99 333.1 0.0 1.4 1 1 0 1 1 1 1 Amidase ERG4_ERG24 PF01222.17 CCF53640.1 - 3.3e-124 414.9 21.7 3.9e-124 414.7 21.7 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family Ribosomal_L29e PF01779.17 CCF53642.1 - 1e-21 77.0 7.1 1.4e-21 76.5 7.1 1.2 1 0 0 1 1 1 1 Ribosomal L29e protein family PHD PF00628.29 CCF53643.1 - 2e-12 46.8 16.9 2.8e-07 30.3 2.6 3.8 4 0 0 4 4 4 2 PHD-finger zf-PHD-like PF15446.6 CCF53643.1 - 1.1 8.9 5.7 2.3 7.8 2.0 2.6 2 0 0 2 2 2 0 PHD/FYVE-zinc-finger like domain zf-HC5HC2H PF13771.6 CCF53643.1 - 1.1 9.5 4.7 0.67 10.2 1.2 2.1 2 0 0 2 2 2 0 PHD-like zinc-binding domain DUF5633 PF18656.1 CCF53643.1 - 1.3 8.9 5.0 0.17 11.8 0.2 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF5633) DUF2849 PF11011.8 CCF53643.1 - 5.1 7.8 5.7 31 5.3 0.2 4.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2849) Vps51 PF08700.11 CCF53644.1 - 2.3e-14 53.2 0.4 1.7e-13 50.4 0.0 2.6 2 0 0 2 2 2 1 Vps51/Vps67 ApoLp-III PF07464.11 CCF53644.1 - 0.046 13.8 7.7 0.14 12.2 0.2 3.1 3 0 0 3 3 3 0 Apolipophorin-III precursor (apoLp-III) DUF2408 PF10303.9 CCF53644.1 - 0.073 13.6 6.2 1.2 9.6 0.5 3.8 3 0 0 3 3 3 0 Protein of unknown function (DUF2408) Pro_isomerase PF00160.21 CCF53645.1 - 3.5e-51 173.6 0.0 3.9e-51 173.5 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Histone_H2A_C PF16211.5 CCF53646.1 - 1.9e-18 65.9 1.1 3.6e-18 65.0 1.1 1.5 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.24 CCF53646.1 - 6.4e-18 65.4 0.0 8e-18 65.1 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 CCF53646.1 - 8.6e-06 25.9 0.0 1.3e-05 25.4 0.0 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 CCF53647.1 - 1.5e-22 80.4 1.5 1.8e-22 80.1 1.5 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 CCF53647.1 - 3e-06 27.4 0.1 3e-06 27.4 0.1 1.7 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.13 CCF53647.1 - 0.00039 20.8 0.0 0.00064 20.2 0.0 1.2 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A CENP-W PF15510.6 CCF53647.1 - 0.037 14.2 0.0 0.056 13.7 0.0 1.2 1 0 0 1 1 1 0 CENP-W protein RP-C PF03428.13 CCF53647.1 - 0.04 13.6 0.3 0.19 11.3 0.3 1.9 1 1 0 1 1 1 0 Replication protein C N-terminal domain DUF1018 PF06252.12 CCF53647.1 - 0.073 14.1 0.5 0.11 13.5 0.5 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1018) Bt_P21 PF05560.11 CCF53647.1 - 0.093 12.3 0.1 0.11 12.1 0.1 1.1 1 0 0 1 1 1 0 Bacillus thuringiensis P21 molecular chaperone protein Snf7 PF03357.21 CCF53648.1 - 2.2e-29 102.3 20.8 2.2e-29 102.3 20.8 1.3 1 1 0 1 1 1 1 Snf7 Eno-Rase_FAD_bd PF07055.12 CCF53648.1 - 0.0056 17.1 0.8 0.017 15.5 0.1 2.2 2 0 0 2 2 2 1 Enoyl reductase FAD binding domain SMODS PF18144.1 CCF53648.1 - 0.0084 16.3 1.7 1.8 8.7 0.4 2.2 1 1 1 2 2 2 2 Second Messenger Oligonucleotide or Dinucleotide Synthetase domain Ribosomal_L29 PF00831.23 CCF53649.1 - 0.15 12.0 0.0 0.35 10.9 0.0 1.6 1 0 0 1 1 1 0 Ribosomal L29 protein MIP PF00230.20 CCF53650.1 - 3e-48 164.5 5.1 3.6e-48 164.2 5.1 1.0 1 0 0 1 1 1 1 Major intrinsic protein PPI_Ypi1 PF07491.11 CCF53651.1 - 8e-27 92.8 0.5 8e-27 92.8 0.5 2.4 3 0 0 3 3 3 1 Protein phosphatase inhibitor SelP_N PF04592.14 CCF53651.1 - 0.39 10.1 11.1 0.54 9.6 11.1 1.3 1 0 0 1 1 1 0 Selenoprotein P, N terminal region CDC45 PF02724.14 CCF53651.1 - 5.5 5.2 8.2 8 4.6 8.2 1.2 1 0 0 1 1 1 0 CDC45-like protein Pkinase PF00069.25 CCF53652.1 - 3.2e-26 92.3 0.0 6.3e-26 91.3 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF53652.1 - 1.1e-12 47.8 0.0 1.6e-11 44.0 0.0 2.4 1 1 0 1 1 1 1 Protein tyrosine kinase Cnd1 PF12717.7 CCF53652.1 - 0.16 12.0 1.3 0.45 10.5 1.1 1.8 1 1 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1 zf-RING_2 PF13639.6 CCF53653.1 - 0.00049 20.4 4.9 0.00049 20.4 4.9 1.8 2 0 0 2 2 2 1 Ring finger domain SWIM PF04434.17 CCF53653.1 - 0.00085 18.9 1.3 0.0016 18.1 1.3 1.4 1 0 0 1 1 1 1 SWIM zinc finger FANCL_C PF11793.8 CCF53653.1 - 0.0049 17.0 2.9 0.01 16.0 2.9 1.5 1 0 0 1 1 1 1 FANCL C-terminal domain zf-RING_5 PF14634.6 CCF53653.1 - 0.064 13.2 2.9 0.13 12.3 2.9 1.5 1 0 0 1 1 1 0 zinc-RING finger domain zf-ANAPC11 PF12861.7 CCF53653.1 - 0.07 13.2 4.9 0.2 11.7 5.0 1.7 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.5 CCF53653.1 - 0.17 11.5 3.3 0.36 10.5 2.3 2.1 1 1 0 1 1 1 0 Zinc-ribbon, C4HC2 type RINGv PF12906.7 CCF53653.1 - 0.21 11.8 4.6 0.45 10.7 4.6 1.6 1 0 0 1 1 1 0 RING-variant domain DUF4407 PF14362.6 CCF53654.1 - 0.0044 16.4 8.9 0.01 15.2 8.9 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4407) DUF2263 PF10021.9 CCF53654.1 - 0.014 15.7 0.9 0.047 14.1 0.1 2.2 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2263) DUF4200 PF13863.6 CCF53654.1 - 1.3 9.4 10.7 1.1 9.7 2.8 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) Fez1 PF06818.15 CCF53654.1 - 1.6 9.2 9.9 6.2 7.2 9.6 2.3 1 1 0 1 1 1 0 Fez1 zf-C4H2 PF10146.9 CCF53654.1 - 9.3 6.5 8.8 2.1 8.6 0.9 2.7 2 1 0 2 2 2 0 Zinc finger-containing protein SPAN-X PF07458.12 CCF53655.1 - 0.32 11.5 5.5 1.2 9.7 3.8 2.9 2 0 0 2 2 2 0 Sperm protein associated with nucleus, mapped to X chromosome Glyco_transf_24 PF18404.1 CCF53656.1 - 5.1e-144 478.6 2.4 7.5e-144 478.0 2.4 1.3 1 0 0 1 1 1 1 Glucosyltransferase 24 Thioredoxin_14 PF18402.1 CCF53656.1 - 1.8e-53 182.1 0.0 1.5e-51 175.8 0.0 2.5 2 0 0 2 2 2 1 Thioredoxin-like domain UDP-g_GGTase PF06427.11 CCF53656.1 - 3.8e-35 120.3 0.0 8e-35 119.3 0.0 1.6 1 0 0 1 1 1 1 UDP-glucose:Glycoprotein Glucosyltransferase Thioredoxin_12 PF18400.1 CCF53656.1 - 7.6e-31 107.5 1.8 2e-30 106.1 1.8 1.8 1 0 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_13 PF18401.1 CCF53656.1 - 5.9e-30 103.9 0.1 2.4e-29 102.0 0.1 2.1 2 0 0 2 2 2 1 Thioredoxin-like domain Thioredoxin_15 PF18403.1 CCF53656.1 - 9.8e-15 55.1 0.1 3.9e-13 49.8 0.1 3.3 4 0 0 4 4 4 1 Thioredoxin-like domain Glyco_transf_8 PF01501.20 CCF53656.1 - 5.8e-07 29.3 0.0 1.2e-06 28.3 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 8 ThiC_Rad_SAM PF01964.18 CCF53657.1 - 0.15 10.8 0.0 0.2 10.4 0.0 1.1 1 0 0 1 1 1 0 Radical SAM ThiC family DPBB_1 PF03330.18 CCF53658.1 - 3.2e-08 33.7 1.0 1.4e-07 31.6 1.0 2.2 1 1 0 1 1 1 1 Lytic transglycolase Pkinase PF00069.25 CCF53659.1 - 1.3e-65 221.4 0.0 1.7e-65 221.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF53659.1 - 1.3e-35 123.0 0.0 5.4e-34 117.7 0.0 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 CCF53659.1 - 0.038 13.3 0.0 0.12 11.6 0.0 1.7 2 1 0 2 2 2 0 Kinase-like Pkinase_fungal PF17667.1 CCF53659.1 - 0.052 12.3 0.0 0.098 11.4 0.0 1.4 1 0 0 1 1 1 0 Fungal protein kinase Seadorna_VP7 PF07387.11 CCF53659.1 - 0.055 12.5 0.1 0.11 11.5 0.1 1.5 1 0 0 1 1 1 0 Seadornavirus VP7 Haspin_kinase PF12330.8 CCF53659.1 - 0.062 12.2 0.1 0.33 9.9 0.0 1.9 2 0 0 2 2 2 0 Haspin like kinase domain APH PF01636.23 CCF53659.1 - 0.064 13.2 0.0 0.47 10.3 0.1 2.0 2 0 0 2 2 2 0 Phosphotransferase enzyme family GST_N_2 PF13409.6 CCF53660.1 - 2.3e-20 72.7 0.0 4e-20 71.9 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 CCF53660.1 - 1.2e-13 50.8 0.0 2.8e-13 49.7 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 CCF53660.1 - 0.0027 18.1 0.2 0.021 15.3 0.2 2.2 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 CCF53660.1 - 0.0039 17.4 0.0 0.007 16.6 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain RasGEF PF00617.19 CCF53661.1 - 2.3e-50 171.3 0.0 2.3e-50 171.3 0.0 1.8 2 0 0 2 2 2 1 RasGEF domain RasGEF_N PF00618.20 CCF53661.1 - 6.7e-24 84.1 0.0 6.7e-24 84.1 0.0 2.4 2 0 0 2 2 2 1 RasGEF N-terminal motif SH3_2 PF07653.17 CCF53661.1 - 1.6e-14 53.3 0.0 3.4e-14 52.2 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 CCF53661.1 - 6e-13 48.4 0.1 1.5e-12 47.2 0.1 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 CCF53661.1 - 8.9e-13 47.6 0.1 1.7e-12 46.8 0.1 1.5 1 0 0 1 1 1 1 SH3 domain DDHD PF02862.17 CCF53661.1 - 0.052 13.7 4.9 0.19 11.9 4.9 2.1 1 0 0 1 1 1 0 DDHD domain DUF775 PF05603.12 CCF53661.1 - 1.1 8.8 12.2 19 4.7 9.7 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF775) eIF-3_zeta PF05091.12 CCF53661.1 - 4.1 6.3 11.7 7 5.5 11.7 1.3 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF4834 PF16118.5 CCF53661.1 - 6.6 7.8 11.1 44 5.1 11.1 2.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) 2-oxoacid_dh PF00198.23 CCF53662.1 - 1.9e-78 263.1 0.1 2.5e-78 262.7 0.1 1.2 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 CCF53662.1 - 1.1e-19 70.0 1.4 2.2e-19 69.0 1.4 1.5 1 0 0 1 1 1 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.6 CCF53662.1 - 8.3e-06 25.5 0.0 0.0081 16.0 0.0 2.4 1 1 1 2 2 2 2 Biotin-lipoyl like HlyD_3 PF13437.6 CCF53662.1 - 2.4e-05 25.0 0.1 0.19 12.4 0.0 2.4 1 1 1 2 2 2 2 HlyD family secretion protein GCV_H PF01597.19 CCF53662.1 - 0.0018 18.2 0.4 0.0038 17.1 0.4 1.6 1 0 0 1 1 1 1 Glycine cleavage H-protein Macoilin PF09726.9 CCF53662.1 - 0.042 12.4 13.5 0.046 12.3 13.5 1.2 1 0 0 1 1 1 0 Macoilin family Apt1 PF10351.9 CCF53662.1 - 0.056 12.3 21.9 0.088 11.7 21.9 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain YL1 PF05764.13 CCF53662.1 - 0.09 12.9 21.5 0.15 12.2 21.5 1.2 1 0 0 1 1 1 0 YL1 nuclear protein FAM76 PF16046.5 CCF53662.1 - 0.14 11.5 17.4 0.77 9.0 13.8 2.1 2 0 0 2 2 2 0 FAM76 protein Lin-8 PF03353.15 CCF53662.1 - 0.18 11.3 12.6 0.27 10.7 12.6 1.3 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist HlyD_D23 PF16576.5 CCF53662.1 - 0.19 10.9 2.1 0.21 10.8 0.1 2.0 2 1 0 2 2 2 0 Barrel-sandwich domain of CusB or HlyD membrane-fusion FAM220 PF15487.6 CCF53662.1 - 0.5 10.0 21.8 0.089 12.4 17.6 1.8 2 0 0 2 2 2 0 FAM220 family U79_P34 PF03064.16 CCF53662.1 - 0.71 9.2 8.9 1.4 8.3 8.9 1.4 1 0 0 1 1 1 0 HSV U79 / HCMV P34 GREB1 PF15782.5 CCF53662.1 - 2.3 5.2 21.3 2.9 4.9 21.3 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer BHD_2 PF10404.9 CCF53663.1 - 0.35 11.9 1.9 0.95 10.5 0.2 2.7 2 0 0 2 2 2 0 Rad4 beta-hairpin domain 2 Radial_spoke_3 PF06098.11 CCF53663.1 - 0.46 9.7 8.7 1.6 8.0 8.7 1.9 1 0 0 1 1 1 0 Radial spoke protein 3 PV-1 PF06637.11 CCF53664.1 - 6.5 5.5 12.9 15 4.2 12.9 1.5 1 0 0 1 1 1 0 PV-1 protein (PLVAP) Forkhead PF00250.18 CCF53666.1 - 3.1e-19 69.0 0.0 7.5e-19 67.8 0.0 1.6 2 0 0 2 2 2 1 Forkhead domain Amidohydro_1 PF01979.20 CCF53667.1 - 5.4e-08 32.5 0.0 9.9e-08 31.7 0.0 1.6 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_2 PF04909.14 CCF53667.1 - 5.9e-06 26.3 0.0 1.7e-05 24.7 0.0 1.7 1 1 0 1 1 1 1 Amidohydrolase FUN14 PF04930.15 CCF53668.1 - 4.3e-20 71.9 0.5 3.3e-19 69.1 0.5 2.0 2 0 0 2 2 2 1 FUN14 family LSM PF01423.22 CCF53669.1 - 9.2e-17 60.5 0.0 1.1e-16 60.2 0.0 1.1 1 0 0 1 1 1 1 LSM domain Hfq PF17209.3 CCF53669.1 - 0.027 14.1 0.0 0.036 13.7 0.0 1.2 1 0 0 1 1 1 0 Hfq protein DUF150_C PF17384.2 CCF53669.1 - 0.046 13.9 0.0 0.071 13.2 0.0 1.4 1 0 0 1 1 1 0 RimP C-terminal SH3 domain HTH_psq PF05225.16 CCF53670.1 - 0.0083 15.8 0.0 0.017 14.8 0.0 1.5 1 0 0 1 1 1 1 helix-turn-helix, Psq domain PRELI PF04707.14 CCF53671.1 - 9.8e-15 54.7 1.0 9.4e-05 22.3 0.0 4.2 4 0 0 4 4 4 4 PRELI-like family Bromodomain PF00439.25 CCF53672.1 - 1.2e-20 73.4 0.0 2.1e-20 72.6 0.0 1.4 1 0 0 1 1 1 1 Bromodomain MFS_1 PF07690.16 CCF53673.1 - 2e-21 76.3 9.4 2e-21 76.3 9.4 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily TFIID_30kDa PF03540.13 CCF53674.1 - 1.1e-24 86.2 0.0 2.1e-24 85.2 0.0 1.6 1 0 0 1 1 1 1 Transcription initiation factor TFIID 23-30kDa subunit CBS PF00571.28 CCF53674.1 - 3e-08 34.0 0.0 8.8e-05 22.9 0.0 2.7 3 0 0 3 3 3 2 CBS domain FAD_binding_8 PF08022.12 CCF53674.1 - 0.062 13.4 0.0 0.11 12.6 0.0 1.4 1 0 0 1 1 1 0 FAD-binding domain FoP_duplication PF13865.6 CCF53674.1 - 0.063 13.8 0.3 0.16 12.5 0.3 1.6 1 0 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 TAF4 PF05236.14 CCF53674.1 - 0.13 12.0 0.1 0.61 9.8 0.0 2.1 3 0 0 3 3 3 0 Transcription initiation factor TFIID component TAF4 family Med3 PF11593.8 CCF53674.1 - 2.5 7.2 11.5 5.2 6.1 11.5 1.5 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal tRNA-synt_2d PF01409.20 CCF53676.1 - 1.6e-87 293.0 0.0 2.2e-87 292.6 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II core domain (F) PheRS_DBD3 PF18553.1 CCF53676.1 - 2e-09 37.6 0.3 7.1e-09 35.8 0.0 2.1 2 0 0 2 2 2 1 PheRS DNA binding domain 3 tRNA_synthFbeta PF17759.1 CCF53676.1 - 8.5e-09 35.2 0.0 1.7e-05 24.4 0.0 2.2 2 0 0 2 2 2 2 Phenylalanyl tRNA synthetase beta chain CLM domain tRNA-synt_2 PF00152.20 CCF53676.1 - 0.00014 21.1 0.3 0.0025 16.9 0.0 2.7 3 0 0 3 3 3 1 tRNA synthetases class II (D, K and N) PheRS_DBD2 PF18554.1 CCF53676.1 - 0.00085 19.3 0.8 0.0021 18.0 0.8 1.8 1 0 0 1 1 1 1 PheRS DNA binding domain 2 DUF2433 PF10360.9 CCF53676.1 - 0.03 14.4 0.1 0.4 10.8 0.0 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF2433) tRNA-synt_2b PF00587.25 CCF53676.1 - 0.11 12.4 0.0 0.22 11.5 0.0 1.5 1 0 0 1 1 1 0 tRNA synthetase class II core domain (G, H, P, S and T) IBN_N PF03810.19 CCF53677.1 - 1.3e-10 41.1 0.6 1.3e-07 31.4 0.2 3.9 3 1 0 3 3 3 1 Importin-beta N-terminal domain Xpo1 PF08389.12 CCF53677.1 - 0.0051 16.9 0.2 0.071 13.2 0.1 2.9 2 0 0 2 2 2 1 Exportin 1-like protein HEAT_2 PF13646.6 CCF53677.1 - 0.0091 16.4 4.1 0.14 12.6 0.3 3.9 3 0 0 3 3 3 1 HEAT repeats HEAT PF02985.22 CCF53677.1 - 0.084 13.2 0.8 0.68 10.4 0.2 3.1 2 0 0 2 2 2 0 HEAT repeat Acetyltransf_1 PF00583.25 CCF53678.1 - 1.3e-13 51.2 0.0 1.9e-13 50.7 0.0 1.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 CCF53678.1 - 1.9e-06 28.2 0.0 5.2e-06 26.8 0.0 1.7 1 1 1 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 CCF53678.1 - 2.5e-05 24.2 0.0 4.7e-05 23.3 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CCF53678.1 - 0.022 14.7 0.0 0.14 12.1 0.0 2.0 1 1 1 2 2 2 0 FR47-like protein Alpha_E3_glycop PF01563.16 CCF53678.1 - 0.043 13.9 0.1 0.075 13.1 0.1 1.3 1 0 0 1 1 1 0 Alphavirus E3 glycoprotein Acetyltransf_CG PF14542.6 CCF53678.1 - 0.065 13.4 0.0 0.43 10.7 0.0 2.1 1 1 0 2 2 2 0 GCN5-related N-acetyl-transferase PNISR PF15996.5 CCF53679.1 - 2.9 8.1 25.1 1.8 8.8 10.6 2.3 2 0 0 2 2 2 0 Arginine/serine-rich protein PNISR DUF2052 PF09747.9 CCF53679.1 - 7.7 6.6 21.2 6.8 6.8 2.1 2.4 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) DUF410 PF04190.13 CCF53682.1 - 8.7e-64 215.8 0.0 1e-63 215.5 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF410) TPR_7 PF13176.6 CCF53682.1 - 0.18 11.9 0.6 3.7 7.8 0.1 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat PROCN PF08083.11 CCF53683.1 - 6e-219 726.7 5.5 9.7e-219 726.1 5.5 1.3 1 0 0 1 1 1 1 PROCN (NUC071) domain PRP8_domainIV PF12134.8 CCF53683.1 - 1.5e-120 401.0 0.3 2.8e-120 400.2 0.3 1.4 1 0 0 1 1 1 1 PRP8 domain IV core U6-snRNA_bdg PF10596.9 CCF53683.1 - 1.3e-83 278.8 0.5 4e-83 277.1 0.5 2.0 1 0 0 1 1 1 1 U6-snRNA interacting domain of PrP8 PRO8NT PF08082.11 CCF53683.1 - 2e-82 274.5 3.7 4.5e-82 273.4 3.7 1.6 1 0 0 1 1 1 1 PRO8NT (NUC069), PrP8 N-terminal domain U5_2-snRNA_bdg PF10597.9 CCF53683.1 - 4.5e-63 211.3 0.0 9.6e-63 210.2 0.0 1.6 1 0 0 1 1 1 1 U5-snRNA binding site 2 of PrP8 RRM_4 PF10598.9 CCF53683.1 - 3e-46 155.7 0.6 6.7e-46 154.6 0.6 1.7 1 0 0 1 1 1 1 RNA recognition motif of the spliceosomal PrP8 PROCT PF08084.11 CCF53683.1 - 5.2e-38 129.7 0.0 1.1e-37 128.7 0.0 1.5 1 0 0 1 1 1 1 PROCT (NUC072) domain JAB PF01398.21 CCF53683.1 - 0.01 15.8 0.0 0.025 14.6 0.0 1.6 1 0 0 1 1 1 0 JAB1/Mov34/MPN/PAD-1 ubiquitin protease ANAPC_CDC26 PF10471.9 CCF53685.1 - 5e-05 24.0 10.3 0.00031 21.5 10.3 1.9 1 1 0 1 1 1 1 Anaphase-promoting complex APC subunit CDC26 DUF4866 PF16160.5 CCF53685.1 - 0.086 12.2 0.1 0.098 12.0 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4866) Wtap PF17098.5 CCF53686.1 - 4.4e-11 43.0 0.2 7.3e-11 42.2 0.2 1.4 1 0 0 1 1 1 1 WTAP/Mum2p family Pyr_redox_3 PF13738.6 CCF53687.1 - 1.1e-18 67.6 0.6 1.8e-17 63.5 0.0 2.7 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.19 CCF53687.1 - 6.8e-13 47.9 0.3 4.7e-09 35.2 0.0 3.1 3 1 0 3 3 3 2 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.14 CCF53687.1 - 1.1e-11 44.6 0.0 1.5e-10 40.8 0.1 2.0 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 CCF53687.1 - 3.5e-10 39.6 0.5 1.4e-05 24.4 0.1 3.1 2 1 1 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 CCF53687.1 - 0.0029 17.6 4.9 0.78 9.7 0.2 3.4 2 1 1 3 3 3 2 FAD-NAD(P)-binding DAO PF01266.24 CCF53687.1 - 0.058 13.0 1.5 0.57 9.7 0.2 2.8 3 0 0 3 3 3 0 FAD dependent oxidoreductase Pyr_redox PF00070.27 CCF53687.1 - 0.11 13.0 0.1 6.8 7.3 0.0 2.6 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase PEP-CTERM PF07589.11 CCF53688.1 - 3 8.1 6.5 31 4.9 0.2 2.9 2 0 0 2 2 2 0 PEP-CTERM motif RVT_1 PF00078.27 CCF53689.1 - 2.5e-08 33.7 0.0 4.3e-08 32.9 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 CCF53689.1 - 3.7e-05 24.0 0.0 6.7e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 CCF53689.1 - 0.00027 20.9 0.0 0.00053 20.0 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase JAB PF01398.21 CCF53690.1 - 8.6e-32 109.6 0.0 1.7e-31 108.7 0.0 1.5 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.6 CCF53690.1 - 4.8e-15 56.0 1.3 4.8e-15 56.0 1.3 1.8 2 0 0 2 2 2 1 Maintenance of mitochondrial structure and function Prok-JAB PF14464.6 CCF53690.1 - 1.1e-05 25.2 0.0 1.9e-05 24.4 0.0 1.4 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain DUF5624 PF18538.1 CCF53690.1 - 0.0086 16.2 0.3 0.017 15.2 0.3 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF5624) Arf PF00025.21 CCF53691.1 - 1e-39 135.8 0.0 1.2e-39 135.6 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 CCF53691.1 - 6.4e-17 61.6 0.0 7.7e-17 61.4 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CCF53691.1 - 2.2e-15 56.9 0.0 3e-15 56.5 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 CCF53691.1 - 2.7e-09 36.7 0.0 3.2e-09 36.5 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 CCF53691.1 - 1.8e-07 30.8 0.0 2e-07 30.6 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 CCF53691.1 - 3.5e-07 30.3 0.0 5.3e-07 29.7 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase G-alpha PF00503.20 CCF53691.1 - 2e-05 24.0 0.3 5.1e-05 22.6 0.1 1.8 1 1 1 2 2 2 1 G-protein alpha subunit Dynamin_N PF00350.23 CCF53691.1 - 0.0039 17.3 0.1 0.2 11.7 0.2 2.1 1 1 1 2 2 2 1 Dynamin family GTP_EFTU PF00009.27 CCF53691.1 - 0.019 14.5 0.0 1.4 8.4 0.0 2.1 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain AAA_18 PF13238.6 CCF53691.1 - 0.047 14.2 0.0 0.067 13.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain ATP_bind_1 PF03029.17 CCF53691.1 - 0.093 12.5 0.0 3.1 7.5 0.0 2.0 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein AAA_7 PF12775.7 CCF53691.1 - 0.16 11.4 0.0 0.26 10.8 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region Vps52 PF04129.12 CCF53692.1 - 4.1e-35 121.5 0.0 1.3e-26 93.5 0.0 2.8 3 0 0 3 3 3 2 Vps52 / Sac2 family Sec3_C PF09763.9 CCF53692.1 - 0.035 12.5 0.1 0.084 11.2 0.0 1.6 2 0 0 2 2 2 0 Exocyst complex component Sec3 CHAD PF05235.14 CCF53692.1 - 0.063 13.2 0.3 0.12 12.3 0.3 1.5 1 0 0 1 1 1 0 CHAD domain Pkinase PF00069.25 CCF53693.1 - 5.6e-66 222.6 0.0 8.9e-66 221.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF53693.1 - 3.9e-36 124.7 0.0 3.5e-25 88.8 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Seadorna_VP7 PF07387.11 CCF53693.1 - 0.0021 17.2 0.1 0.0035 16.4 0.1 1.2 1 0 0 1 1 1 1 Seadornavirus VP7 Kinase-like PF14531.6 CCF53693.1 - 0.0036 16.7 1.4 0.015 14.6 0.1 2.4 3 0 0 3 3 3 1 Kinase-like APH PF01636.23 CCF53693.1 - 0.028 14.4 2.0 0.028 14.4 0.0 2.1 2 0 0 2 2 2 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 CCF53693.1 - 0.081 11.7 1.6 0.15 10.8 0.0 2.1 2 0 0 2 2 2 0 Fungal protein kinase FTA2 PF13095.6 CCF53693.1 - 0.086 12.4 0.0 0.25 11.0 0.0 1.7 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Sec10 PF07393.11 CCF53693.1 - 0.21 10.0 3.3 0.38 9.1 3.3 1.3 1 0 0 1 1 1 0 Exocyst complex component Sec10 MOFRL PF05161.13 CCF53693.1 - 6.2 7.1 7.4 0.97 9.7 1.0 2.7 2 0 0 2 2 2 0 MOFRL family DUF4219 PF13961.6 CCF53696.1 - 0.059 13.1 0.6 0.11 12.2 0.1 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4219) Retrotran_gag_3 PF14244.6 CCF53696.1 - 0.16 11.8 0.0 0.37 10.6 0.0 1.5 1 0 0 1 1 1 0 gag-polypeptide of LTR copia-type Oxidored_FMN PF00724.20 CCF53697.1 - 2e-39 135.8 0.0 2.7e-39 135.4 0.0 1.1 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Acetyltransf_7 PF13508.7 CCF53698.1 - 0.012 16.1 0.0 0.017 15.5 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CCF53698.1 - 0.025 14.8 0.0 0.035 14.3 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family FR47 PF08445.10 CCF53698.1 - 0.14 12.1 0.0 0.28 11.2 0.0 1.4 1 0 0 1 1 1 0 FR47-like protein Pmp3 PF01679.17 CCF53699.1 - 9.1e-26 89.8 7.1 1e-25 89.7 7.1 1.0 1 0 0 1 1 1 1 Proteolipid membrane potential modulator adh_short PF00106.25 CCF53700.1 - 7e-39 133.3 0.1 1e-38 132.8 0.1 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF53700.1 - 1.3e-26 93.6 0.1 1.8e-26 93.2 0.1 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF53700.1 - 4e-08 33.4 1.2 8.2e-08 32.4 1.2 1.5 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CCF53700.1 - 0.012 15.1 0.1 0.018 14.5 0.1 1.4 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CCF53700.1 - 0.021 14.2 0.1 0.028 13.8 0.1 1.1 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase DUF2007 PF09413.10 CCF53700.1 - 0.053 13.7 0.0 0.12 12.6 0.0 1.6 1 0 0 1 1 1 0 Putative prokaryotic signal transducing protein Fungal_trans_2 PF11951.8 CCF53702.1 - 8e-20 71.0 0.5 3.8e-17 62.2 0.1 2.1 2 0 0 2 2 2 2 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF53702.1 - 3.9e-07 30.1 9.0 6.2e-07 29.4 9.0 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain BLM10_N PF16547.5 CCF53702.1 - 0.33 11.3 1.8 0.38 11.1 0.1 2.0 2 0 0 2 2 2 0 Proteasome-substrate-size regulator, N-terminal DnaJ_C PF01556.18 CCF53703.1 - 2.4e-26 92.6 0.0 3.6e-26 92.0 0.0 1.3 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 CCF53703.1 - 2e-21 75.8 4.1 3.5e-21 75.1 4.1 1.4 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 CCF53703.1 - 5.6e-15 55.4 13.4 1e-14 54.6 13.4 1.4 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 CCF53703.1 - 8.1e-05 22.5 6.4 0.11 12.5 0.5 2.5 2 0 0 2 2 2 2 Tryptophan RNA-binding attenuator protein inhibitory protein HypA PF01155.19 CCF53703.1 - 0.0021 18.0 4.3 0.9 9.6 0.9 2.3 2 0 0 2 2 2 2 Hydrogenase/urease nickel incorporation, metallochaperone, hypA A2L_zn_ribbon PF08792.10 CCF53703.1 - 0.086 12.6 0.0 0.086 12.6 0.0 3.5 3 1 1 4 4 4 0 A2L zinc ribbon domain Lar_restr_allev PF14354.6 CCF53703.1 - 0.8 10.1 4.1 3.4 8.1 2.6 2.7 2 1 0 2 2 2 0 Restriction alleviation protein Lar RseC_MucC PF04246.12 CCF53703.1 - 9 6.3 7.1 40 4.2 2.5 2.5 2 0 0 2 2 2 0 Positive regulator of sigma(E), RseC/MucC Indigoidine_A PF04227.12 CCF53704.1 - 3.4e-113 377.8 0.8 4e-113 377.6 0.8 1.0 1 0 0 1 1 1 1 Indigoidine synthase A like protein Arm PF00514.23 CCF53704.1 - 0.091 12.8 0.2 0.71 10.0 0.0 2.3 2 0 0 2 2 2 0 Armadillo/beta-catenin-like repeat DUF1932 PF09130.11 CCF53704.1 - 0.1 12.6 0.1 0.48 10.4 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1932) AP_endonuc_2 PF01261.24 CCF53705.1 - 5.2e-19 68.5 0.1 1.5e-13 50.7 0.0 3.2 2 1 0 2 2 2 2 Xylose isomerase-like TIM barrel FKBP_C PF00254.28 CCF53706.1 - 2.1e-29 101.7 0.1 7.6e-29 99.9 0.0 1.9 2 0 0 2 2 2 1 FKBP-type peptidyl-prolyl cis-trans isomerase NPL PF17800.1 CCF53706.1 - 1.4e-15 57.7 0.1 1.4e-15 57.7 0.1 2.2 2 1 0 2 2 2 1 Nucleoplasmin-like domain YL1 PF05764.13 CCF53706.1 - 0.00028 21.1 26.2 0.00036 20.7 20.1 2.1 2 0 0 2 2 2 1 YL1 nuclear protein GREB1 PF15782.5 CCF53706.1 - 0.69 7.0 2.7 0.87 6.6 2.7 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer RXT2_N PF08595.11 CCF53707.1 - 0.013 15.5 5.4 1.1 9.2 0.3 2.2 2 0 0 2 2 2 0 RXT2-like, N-terminal AATF-Che1 PF13339.6 CCF53707.1 - 0.055 14.1 0.3 0.055 14.1 0.3 1.8 2 0 0 2 2 2 0 Apoptosis antagonizing transcription factor PBP1_TM PF14812.6 CCF53707.1 - 0.11 12.9 0.4 0.11 12.9 0.4 2.1 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF1682 PF07946.14 CCF53708.1 - 0.01 15.1 0.3 0.014 14.6 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) DUF2540 PF10802.8 CCF53708.1 - 0.023 14.8 0.8 0.049 13.7 0.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2540) MDMPI_N PF11716.8 CCF53708.1 - 0.076 13.7 3.2 0.16 12.7 3.2 1.5 1 0 0 1 1 1 0 Mycothiol maleylpyruvate isomerase N-terminal domain Glyco_hydro_92 PF07971.12 CCF53709.1 - 2.4e-112 376.2 0.0 3.3e-112 375.7 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 Glyco_hydro_92N PF17678.1 CCF53709.1 - 8.1e-39 133.9 0.0 1.1e-38 133.4 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 N-terminal domain RVT_2 PF07727.14 CCF53710.1 - 4.8e-21 75.5 0.1 5.3e-21 75.4 0.1 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) MutS_II PF05188.17 CCF53711.1 - 0.016 15.5 0.3 3.7 7.8 0.1 2.8 2 1 0 3 3 3 0 MutS domain II LOR PF04525.12 CCF53712.1 - 1.8e-21 76.6 0.0 2.2e-21 76.3 0.0 1.0 1 0 0 1 1 1 1 LURP-one-related DUF1295 PF06966.12 CCF53713.1 - 4.5e-49 167.1 0.0 7.2e-49 166.4 0.0 1.4 1 1 1 2 2 2 1 Protein of unknown function (DUF1295) ICMT PF04140.14 CCF53713.1 - 2.7e-05 24.5 0.0 9e-05 22.8 0.0 1.8 2 0 0 2 2 2 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family Steroid_dh PF02544.16 CCF53713.1 - 0.00034 20.6 0.0 0.00065 19.7 0.0 1.5 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase PEMT PF04191.13 CCF53713.1 - 0.053 13.9 2.2 0.074 13.5 0.1 2.4 2 1 0 2 2 2 0 Phospholipid methyltransferase DUF4126 PF13548.6 CCF53713.1 - 0.12 12.1 2.2 1.1 8.9 0.1 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4126) Choline_transpo PF04515.12 CCF53714.1 - 2.2e-71 240.7 28.8 2.2e-71 240.7 28.8 2.3 2 1 0 2 2 2 1 Plasma-membrane choline transporter AMP-binding PF00501.28 CCF53715.1 - 2.3e-65 220.9 0.0 2.4e-63 214.2 0.0 2.5 2 1 0 2 2 2 2 AMP-binding enzyme AMP-binding_C PF13193.6 CCF53715.1 - 1.5e-05 25.8 0.0 5.2e-05 24.1 0.0 2.0 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain zf-DNL PF05180.12 CCF53717.1 - 4.1e-29 100.3 0.5 6.2e-29 99.7 0.5 1.3 1 0 0 1 1 1 1 DNL zinc finger Lar_restr_allev PF14354.6 CCF53717.1 - 0.028 14.8 0.1 0.05 14.0 0.1 1.4 1 0 0 1 1 1 0 Restriction alleviation protein Lar zinc_ribbon_4 PF13717.6 CCF53717.1 - 0.077 12.9 0.5 0.46 10.4 0.1 2.3 2 0 0 2 2 2 0 zinc-ribbon domain TF_Zn_Ribbon PF08271.12 CCF53717.1 - 0.1 12.2 0.1 0.24 11.0 0.1 1.7 1 0 0 1 1 1 0 TFIIB zinc-binding Amidase PF01425.21 CCF53718.1 - 1.3e-94 317.8 0.0 2e-94 317.1 0.0 1.3 1 1 0 1 1 1 1 Amidase APG6_N PF17675.1 CCF53718.1 - 0.084 13.4 0.1 2.2 8.8 0.1 2.2 2 0 0 2 2 2 0 Apg6 coiled-coil region AAA_16 PF13191.6 CCF53719.1 - 0.00014 22.3 1.0 0.0064 16.9 0.0 2.8 3 0 0 3 3 3 1 AAA ATPase domain AAA_22 PF13401.6 CCF53719.1 - 0.014 15.6 0.1 0.044 14.1 0.0 1.8 2 0 0 2 2 2 0 AAA domain Cwf_Cwc_15 PF04889.12 CCF53719.1 - 0.033 13.9 6.7 0.062 13.0 6.7 1.5 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein PaaA_PaaC PF05138.12 CCF53719.1 - 0.056 12.6 0.1 0.12 11.5 0.1 1.5 1 0 0 1 1 1 0 Phenylacetic acid catabolic protein NOA36 PF06524.12 CCF53719.1 - 3.4 6.9 8.7 5.8 6.1 8.7 1.3 1 0 0 1 1 1 0 NOA36 protein Pre-PUA PF17832.1 CCF53720.1 - 3.6e-23 82.0 0.0 5.3e-23 81.5 0.0 1.2 1 0 0 1 1 1 1 Pre-PUA-like domain PUA PF01472.20 CCF53720.1 - 7.3e-20 70.7 0.0 1e-19 70.2 0.0 1.2 1 0 0 1 1 1 1 PUA domain SQS_PSY PF00494.19 CCF53721.1 - 1.2e-57 195.4 0.1 1.5e-57 195.1 0.1 1.1 1 0 0 1 1 1 1 Squalene/phytoene synthase PTPLA PF04387.14 CCF53722.1 - 2.2e-54 183.6 8.6 3.1e-54 183.1 7.1 1.9 2 0 0 2 2 2 1 Protein tyrosine phosphatase-like protein, PTPLA Acyl-CoA_dh_1 PF00441.24 CCF53722.1 - 0.1 12.8 0.0 0.15 12.3 0.0 1.2 1 0 0 1 1 1 0 Acyl-CoA dehydrogenase, C-terminal domain HlyIII PF03006.20 CCF53723.1 - 3.2e-49 167.7 15.9 4.2e-49 167.3 15.9 1.1 1 0 0 1 1 1 1 Haemolysin-III related Apolipoprotein PF01442.18 CCF53723.1 - 0.82 9.5 10.0 0.067 13.1 3.3 2.3 2 1 0 2 2 2 0 Apolipoprotein A1/A4/E domain p450 PF00067.22 CCF53724.1 - 7.7e-83 278.8 0.0 9.5e-83 278.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 BtrH_N PF14399.6 CCF53724.1 - 0.041 14.1 0.0 0.085 13.1 0.0 1.4 1 0 0 1 1 1 0 Butirosin biosynthesis protein H, N-terminal GDPD PF03009.17 CCF53725.1 - 4.9e-30 105.1 0.0 8.8e-30 104.3 0.0 1.4 1 1 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family GDPD_2 PF13653.6 CCF53725.1 - 0.0028 18.0 0.6 0.0028 18.0 0.6 2.4 2 0 0 2 2 2 1 Glycerophosphoryl diester phosphodiesterase family AFG1_ATPase PF03969.16 CCF53727.1 - 1.9e-90 303.4 0.0 6.1e-89 298.4 0.0 2.2 2 0 0 2 2 2 1 AFG1-like ATPase AAA_16 PF13191.6 CCF53727.1 - 2.2e-06 28.2 0.0 6.9e-06 26.6 0.0 1.8 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 CCF53727.1 - 4.8e-05 23.7 0.0 0.00073 19.8 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 CCF53727.1 - 0.00057 20.3 0.1 0.003 18.0 0.1 2.2 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 CCF53727.1 - 0.062 13.7 0.0 0.41 11.1 0.1 2.4 2 0 0 2 2 2 0 RNA helicase AAA_7 PF12775.7 CCF53727.1 - 0.12 11.9 0.0 0.29 10.6 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region RAP1 PF07218.11 CCF53727.1 - 0.44 8.8 3.8 0.7 8.1 3.8 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) SR-25 PF10500.9 CCF53727.1 - 1.9 8.1 15.6 0.16 11.5 10.4 1.7 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Chorion_2 PF03964.15 CCF53727.1 - 3.7 8.4 7.8 2.3 9.1 3.7 2.6 3 0 0 3 3 3 0 Chorion family 2 Glyoxalase_2 PF12681.7 CCF53728.1 - 0.0064 16.4 0.1 0.24 11.3 0.0 2.8 3 0 0 3 3 3 1 Glyoxalase-like domain Glyoxalase PF00903.25 CCF53728.1 - 0.014 15.6 0.0 0.089 13.0 0.0 2.2 1 1 0 1 1 1 0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily MFS_1 PF07690.16 CCF53729.1 - 3.6e-33 114.9 25.6 8.1e-32 110.5 26.1 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily PspB PF06667.12 CCF53729.1 - 0.083 13.0 0.2 2.2 8.4 0.1 2.6 2 0 0 2 2 2 0 Phage shock protein B DUF4381 PF14316.6 CCF53729.1 - 0.2 11.9 1.0 13 6.0 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4381) Abhydrolase_6 PF12697.7 CCF53730.1 - 2.6e-25 90.3 0.4 2.6e-25 90.3 0.4 1.5 2 0 0 2 2 2 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CCF53730.1 - 1.3e-10 40.9 0.2 2.2e-10 40.2 0.2 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Thioesterase PF00975.20 CCF53730.1 - 5.6e-05 23.4 0.0 0.00011 22.4 0.0 1.5 1 0 0 1 1 1 1 Thioesterase domain Abhydrolase_1 PF00561.20 CCF53730.1 - 0.00022 21.0 0.1 0.0094 15.6 0.1 2.3 2 0 0 2 2 2 1 alpha/beta hydrolase fold PGAP1 PF07819.13 CCF53730.1 - 0.0035 17.1 0.0 0.0058 16.4 0.0 1.3 1 0 0 1 1 1 1 PGAP1-like protein Lipase_3 PF01764.25 CCF53730.1 - 0.0035 17.2 0.1 0.0064 16.4 0.1 1.4 1 0 0 1 1 1 1 Lipase (class 3) DUF900 PF05990.12 CCF53730.1 - 0.012 15.2 0.0 0.017 14.7 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) Esterase PF00756.20 CCF53730.1 - 0.016 14.9 0.1 0.03 14.0 0.1 1.5 1 0 0 1 1 1 0 Putative esterase Chlorophyllase2 PF12740.7 CCF53730.1 - 0.019 13.9 0.0 0.028 13.3 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase enzyme Abhydrolase_5 PF12695.7 CCF53730.1 - 0.032 14.0 0.2 0.7 9.6 0.0 2.1 2 0 0 2 2 2 0 Alpha/beta hydrolase family DUF2974 PF11187.8 CCF53730.1 - 0.12 11.9 0.0 0.21 11.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) Sugar_tr PF00083.24 CCF53731.1 - 2.2e-51 175.2 18.6 2.7e-51 174.8 18.6 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF53731.1 - 6.3e-25 87.8 30.9 1.6e-13 50.3 13.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_4 PF06779.14 CCF53731.1 - 0.00057 19.3 7.2 0.00095 18.6 2.7 2.3 2 0 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB DUF5504 PF17608.2 CCF53731.1 - 0.1 12.7 0.4 0.1 12.7 0.4 2.6 3 0 0 3 3 3 0 Family of unknown function (DUF5504) TPMT PF05724.11 CCF53733.1 - 6.3e-27 94.6 0.0 1.3e-21 77.2 0.0 2.1 2 0 0 2 2 2 2 Thiopurine S-methyltransferase (TPMT) Methyltransf_25 PF13649.6 CCF53733.1 - 7.8e-05 23.3 0.0 0.00013 22.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF53733.1 - 0.0004 21.0 0.0 0.00081 20.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF53733.1 - 0.00048 20.0 0.0 0.00074 19.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF53733.1 - 0.0021 18.7 0.0 0.0037 18.0 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCF53733.1 - 0.0071 16.2 0.0 0.013 15.3 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain MIOX PF05153.15 CCF53736.1 - 1.7e-119 398.0 0.6 2.1e-119 397.7 0.6 1.1 1 0 0 1 1 1 1 Myo-inositol oxygenase HD PF01966.22 CCF53736.1 - 0.0023 18.2 0.1 1.1 9.5 0.0 2.5 2 0 0 2 2 2 2 HD domain Pro_dh PF01619.18 CCF53737.1 - 7.6e-50 170.1 0.0 2e-32 112.9 0.0 3.1 2 1 0 2 2 2 2 Proline dehydrogenase DUF3239 PF11580.8 CCF53737.1 - 0.053 13.8 0.0 2.7 8.3 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3239) PQ-loop PF04193.14 CCF53738.1 - 2e-18 65.9 21.5 4.4e-10 39.2 4.0 3.7 4 0 0 4 4 4 2 PQ loop repeat NOA36 PF06524.12 CCF53738.1 - 0.22 10.8 3.8 0.35 10.2 3.8 1.2 1 0 0 1 1 1 0 NOA36 protein MtN3_slv PF03083.16 CCF53738.1 - 4.4 7.4 8.7 0.23 11.5 0.3 2.8 3 0 0 3 3 3 0 Sugar efflux transporter for intercellular exchange Zn_clus PF00172.18 CCF53739.1 - 5e-05 23.3 7.3 9e-05 22.5 7.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 CCF53739.1 - 0.00013 21.1 2.9 0.0012 17.9 0.2 2.3 2 0 0 2 2 2 2 Fungal specific transcription factor domain CDC45 PF02724.14 CCF53739.1 - 1 7.6 6.6 2.2 6.5 6.6 1.5 1 0 0 1 1 1 0 CDC45-like protein MFS_1 PF07690.16 CCF53740.1 - 4.3e-40 137.7 44.8 4.3e-40 137.7 44.8 1.5 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF53740.1 - 5.1e-10 38.8 9.8 5.1e-10 38.8 9.8 2.1 3 0 0 3 3 3 1 Sugar (and other) transporter DUF1673 PF07895.11 CCF53740.1 - 9 5.9 10.4 0.089 12.5 0.9 2.4 3 1 0 3 3 3 0 Protein of unknown function (DUF1673) Sdh5 PF03937.16 CCF53741.1 - 6.5e-26 90.1 2.2 1.2e-25 89.3 2.2 1.4 1 0 0 1 1 1 1 Flavinator of succinate dehydrogenase DUF4527 PF15030.6 CCF53741.1 - 1.3 8.4 3.8 0.5 9.7 0.3 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF4527) YCII PF03795.14 CCF53742.1 - 0.082 13.3 0.0 0.28 11.6 0.0 1.9 1 1 0 1 1 1 0 YCII-related domain Pyr_redox_2 PF07992.14 CCF53743.1 - 3.5e-51 174.2 5.7 4.3e-51 173.9 5.7 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Rieske PF00355.26 CCF53743.1 - 8.7e-16 57.6 0.0 1.9e-15 56.5 0.0 1.6 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Pyr_redox_3 PF13738.6 CCF53743.1 - 1.1e-12 47.8 3.4 1.6e-11 44.1 0.2 2.5 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CCF53743.1 - 1.4e-11 44.7 10.5 4.4e-11 43.2 1.4 2.8 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 CCF53743.1 - 0.00013 21.2 1.6 3.4 6.7 0.1 3.2 2 1 1 3 3 3 3 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 CCF53743.1 - 0.00087 19.3 1.0 0.035 14.1 0.1 2.9 3 0 0 3 3 3 1 FAD-NAD(P)-binding GIDA PF01134.22 CCF53743.1 - 0.00091 18.4 1.9 0.028 13.5 0.1 2.4 2 0 0 2 2 2 1 Glucose inhibited division protein A Reductase_C PF14759.6 CCF53743.1 - 0.0032 18.0 0.0 0.021 15.4 0.0 2.3 2 0 0 2 2 2 1 Reductase C-terminal Rieske_2 PF13806.6 CCF53743.1 - 0.0074 16.2 0.0 0.026 14.5 0.0 1.9 2 0 0 2 2 1 1 Rieske-like [2Fe-2S] domain DUF1188 PF06690.11 CCF53743.1 - 0.011 15.3 0.0 0.018 14.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1188) FAD_binding_2 PF00890.24 CCF53743.1 - 0.072 12.2 6.3 1.6 7.8 0.2 3.5 3 1 0 4 4 4 0 FAD binding domain HI0933_like PF03486.14 CCF53743.1 - 0.23 10.1 7.9 0.33 9.6 0.0 3.7 4 1 1 5 5 5 0 HI0933-like protein Eno-Rase_NADH_b PF12242.8 CCF53743.1 - 0.24 11.2 0.1 0.24 11.2 0.1 2.0 2 0 0 2 2 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase TrkA_N PF02254.18 CCF53743.1 - 0.68 10.2 4.9 6 7.2 0.3 2.9 3 1 0 3 3 3 0 TrkA-N domain DAO PF01266.24 CCF53743.1 - 0.69 9.4 6.0 6.7 6.2 0.1 3.4 2 2 0 3 3 3 0 FAD dependent oxidoreductase TAL_FSA PF00923.19 CCF53744.1 - 1.3e-45 156.0 0.8 2e-45 155.4 0.3 1.5 2 0 0 2 2 2 1 Transaldolase/Fructose-6-phosphate aldolase Dfp1_Him1_M PF08630.10 CCF53744.1 - 0.16 12.1 0.0 0.38 11.0 0.0 1.5 1 0 0 1 1 1 0 Dfp1/Him1, central region DnaJ PF00226.31 CCF53746.1 - 6e-16 58.3 2.0 1.4e-15 57.1 2.0 1.7 1 0 0 1 1 1 1 DnaJ domain DUF2924 PF11149.8 CCF53746.1 - 1.3 9.4 5.9 0.47 10.8 3.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2924) zf-rbx1 PF12678.7 CCF53747.1 - 1.1e-05 25.6 3.3 2.3e-05 24.6 3.3 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 CCF53747.1 - 5.6e-05 22.9 0.3 0.00013 21.7 0.3 1.7 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CCF53747.1 - 0.00029 21.1 7.7 0.00063 20.0 4.1 2.3 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 CCF53747.1 - 0.005 16.7 9.1 0.043 13.7 4.6 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CCF53747.1 - 0.083 12.9 6.8 0.13 12.2 5.6 1.9 1 1 1 2 2 2 0 zinc-RING finger domain Zn-ribbon_8 PF09723.10 CCF53747.1 - 0.16 12.1 0.7 0.41 10.8 0.7 1.7 1 0 0 1 1 1 0 Zinc ribbon domain CCDC53 PF10152.9 CCF53747.1 - 1.3 9.5 6.6 11 6.4 1.9 2.3 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex zf-ANAPC11 PF12861.7 CCF53747.1 - 4.1 7.5 7.6 22 5.2 7.6 2.0 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.6 CCF53747.1 - 4.8 7.1 7.7 24 4.9 0.1 2.3 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 SDH_alpha PF03313.15 CCF53748.1 - 1.2e-96 323.4 0.1 1.4e-96 323.1 0.1 1.1 1 0 0 1 1 1 1 Serine dehydratase alpha chain SDH_beta PF03315.15 CCF53748.1 - 8.5e-55 185.4 0.1 3.2e-54 183.5 0.0 2.0 2 0 0 2 2 2 1 Serine dehydratase beta chain Zn_clus PF00172.18 CCF53749.1 - 0.0036 17.4 6.4 0.0077 16.3 6.4 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Acetyltransf_8 PF13523.6 CCF53750.1 - 9.1e-39 132.4 0.3 1.9e-38 131.4 0.3 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain ADH_zinc_N PF00107.26 CCF53751.1 - 7.9e-30 103.5 0.6 1.2e-29 102.9 0.6 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CCF53751.1 - 1.5e-12 48.7 0.0 2.5e-12 48.0 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CCF53751.1 - 0.00012 22.0 0.0 0.00026 20.8 0.0 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain AlaDh_PNT_C PF01262.21 CCF53751.1 - 0.0021 17.4 0.3 0.0034 16.7 0.3 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain HupF_HypC PF01455.18 CCF53751.1 - 0.031 14.4 0.2 0.27 11.4 0.0 2.3 2 0 0 2 2 2 0 HupF/HypC family Oxidored_FMN PF00724.20 CCF53752.1 - 9.9e-51 173.0 0.0 1.4e-50 172.5 0.0 1.2 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family DUF2034 PF10356.9 CCF53753.1 - 2.6e-11 43.3 0.3 1.6e-05 24.4 0.0 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF2034) Mrr_cat PF04471.12 CCF53753.1 - 3.3e-06 27.1 0.0 5.9e-06 26.3 0.0 1.4 1 1 0 1 1 1 1 Restriction endonuclease TPR_11 PF13414.6 CCF53754.1 - 2.9e-18 65.3 3.2 4.9e-07 29.3 0.1 4.3 3 1 1 4 4 4 4 TPR repeat TPR_1 PF00515.28 CCF53754.1 - 3.2e-16 58.4 0.0 1.7e-05 24.4 0.0 4.5 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_2 PF07719.17 CCF53754.1 - 2.8e-14 52.0 0.7 1.3e-05 25.0 0.0 4.3 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_16 PF13432.6 CCF53754.1 - 2.9e-14 53.4 1.4 1.4e-08 35.2 0.0 2.8 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 CCF53754.1 - 8.2e-11 42.0 1.4 0.0013 19.0 0.0 3.3 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_19 PF14559.6 CCF53754.1 - 2.7e-10 40.6 5.7 0.00036 21.0 0.1 3.2 2 1 0 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 CCF53754.1 - 8.8e-10 38.3 0.2 0.01 16.1 0.0 3.8 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_14 PF13428.6 CCF53754.1 - 3.6e-08 33.6 4.7 0.083 13.7 0.1 4.2 1 1 3 4 4 4 4 Tetratricopeptide repeat TPR_8 PF13181.6 CCF53754.1 - 2.7e-07 30.2 0.5 0.31 11.4 0.0 4.5 3 2 1 4 4 4 2 Tetratricopeptide repeat TPR_15 PF13429.6 CCF53754.1 - 6.3e-05 22.3 0.3 0.00011 21.5 0.2 1.4 1 1 0 1 1 1 1 Tetratricopeptide repeat ANAPC3 PF12895.7 CCF53754.1 - 0.00013 22.1 2.4 0.25 11.6 0.0 3.2 1 1 3 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 CCF53754.1 - 0.00073 20.0 0.7 0.12 13.1 0.0 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_9 PF13371.6 CCF53754.1 - 0.0065 16.6 1.0 0.044 13.9 0.0 2.4 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.6 CCF53754.1 - 0.017 15.2 3.1 9.2 6.6 0.0 4.1 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_20 PF14561.6 CCF53754.1 - 0.11 12.9 6.8 0.27 11.6 0.1 3.3 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_10 PF13374.6 CCF53754.1 - 0.25 11.3 2.3 34 4.5 0.6 3.4 3 1 1 4 4 4 0 Tetratricopeptide repeat DDE_3 PF13358.6 CCF53755.1 - 5.4e-08 32.7 1.4 9.5e-08 31.9 1.4 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease SUR7 PF06687.12 CCF53756.1 - 4.6e-10 39.5 8.3 6.6e-10 39.0 8.3 1.2 1 0 0 1 1 1 1 SUR7/PalI family DUF2768 PF10966.8 CCF53756.1 - 0.11 12.9 0.3 0.11 12.9 0.3 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF2768) RVT_2 PF07727.14 CCF53757.1 - 0.035 13.7 0.0 0.04 13.6 0.0 1.1 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) Endonuclease_NS PF01223.23 CCF53757.1 - 0.14 11.9 0.1 0.16 11.8 0.1 1.0 1 0 0 1 1 1 0 DNA/RNA non-specific endonuclease SKG6 PF08693.10 CCF53759.1 - 0.002 17.5 6.7 0.0028 17.0 6.7 1.2 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Rax2 PF12768.7 CCF53759.1 - 0.0051 16.3 0.1 0.0069 15.9 0.1 1.1 1 0 0 1 1 1 1 Cortical protein marker for cell polarity EphA2_TM PF14575.6 CCF53759.1 - 0.038 14.9 0.0 0.049 14.5 0.0 1.2 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain GT87 PF09594.10 CCF53759.1 - 0.14 11.8 0.4 0.19 11.4 0.4 1.1 1 0 0 1 1 1 0 Glycosyltransferase family 87 Chordopox_A13L PF05961.11 CCF53759.1 - 0.19 12.0 0.0 0.3 11.4 0.0 1.3 1 0 0 1 1 1 0 Chordopoxvirus A13L protein RCR PF12273.8 CCF53759.1 - 6 7.5 31.1 45 4.7 31.1 2.4 1 1 0 1 1 1 0 Chitin synthesis regulation, resistance to Congo red ALO PF04030.14 CCF53760.1 - 3.6e-63 213.8 3.6 6.5e-54 183.5 0.4 2.9 3 0 0 3 3 3 2 D-arabinono-1,4-lactone oxidase FAD_binding_4 PF01565.23 CCF53760.1 - 1.1e-18 67.4 0.1 1.9e-18 66.6 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain EI24 PF07264.11 CCF53762.1 - 3.4e-29 102.3 9.4 5.1e-29 101.8 9.4 1.3 1 0 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) Aa_trans PF01490.18 CCF53763.1 - 6.2e-52 176.7 41.2 7.1e-52 176.5 41.2 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein PIRT PF15099.6 CCF53763.1 - 0.044 13.4 0.1 0.044 13.4 0.1 2.4 2 1 1 3 3 3 0 Phosphoinositide-interacting protein family HIG_1_N PF04588.13 CCF53764.1 - 1.3e-16 60.5 0.0 2e-16 59.9 0.0 1.3 1 0 0 1 1 1 1 Hypoxia induced protein conserved region MFS_1 PF07690.16 CCF53766.1 - 5.9e-26 91.2 27.2 5.9e-26 91.2 27.2 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily MFS_4 PF06779.14 CCF53766.1 - 0.0015 17.9 15.3 0.0025 17.2 8.4 2.6 2 1 0 2 2 2 2 Uncharacterised MFS-type transporter YbfB DUF2070 PF09843.9 CCF53766.1 - 3.9 5.7 24.0 0.4 8.9 4.0 2.4 2 0 0 2 2 2 0 Predicted membrane protein (DUF2070) DUF4231 PF14015.6 CCF53766.1 - 7.3 7.1 11.7 2.9 8.4 0.4 3.6 2 1 1 3 3 3 0 Protein of unknown function (DUF4231) Rhodanese PF00581.20 CCF53767.1 - 3.6e-16 59.6 0.0 1.1e-08 35.5 0.0 3.1 2 1 0 2 2 2 2 Rhodanese-like domain ThiC-associated PF13667.6 CCF53767.1 - 0.045 13.6 0.0 0.089 12.6 0.0 1.4 1 0 0 1 1 1 0 ThiC-associated domain Sugar_tr PF00083.24 CCF53768.1 - 8.4e-119 397.4 24.0 9.7e-119 397.2 24.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCF53768.1 - 7.4e-21 74.5 46.7 1.3e-18 67.1 16.8 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Holin_9 PF16936.5 CCF53768.1 - 0.94 9.7 7.1 0.29 11.3 2.7 2.4 2 0 0 2 2 2 0 Putative holin zf-NPL4 PF05020.15 CCF53770.1 - 0.077 13.1 0.7 2.8 8.1 0.2 2.2 1 1 1 2 2 2 0 NPL4 family, putative zinc binding region CCDC117 PF15810.5 CCF53770.1 - 0.17 12.2 1.4 0.8 10.0 0.0 2.4 2 1 1 3 3 3 0 Coiled-coil domain-containing protein 117 Asp PF00026.23 CCF53771.1 - 1.1e-46 159.8 12.1 3.7e-46 158.0 12.1 1.7 1 1 0 1 1 1 1 Eukaryotic aspartyl protease gag-asp_proteas PF13975.6 CCF53771.1 - 2.7e-08 34.3 2.0 0.0037 17.8 0.3 2.6 2 1 0 2 2 2 2 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 CCF53771.1 - 1.2e-07 32.3 3.2 0.0034 18.0 0.1 2.6 2 0 0 2 2 2 2 Aspartyl protease TAXi_N PF14543.6 CCF53771.1 - 3.8e-05 24.0 8.4 0.037 14.3 0.1 3.1 2 1 1 3 3 3 2 Xylanase inhibitor N-terminal TAXi_C PF14541.6 CCF53771.1 - 0.14 11.9 0.1 0.4 10.5 0.0 1.8 2 0 0 2 2 2 0 Xylanase inhibitor C-terminal LEP503 PF15221.6 CCF53771.1 - 0.16 12.3 0.0 0.58 10.5 0.0 1.9 1 0 0 1 1 1 0 Lens epithelial cell protein LEP503 Ribonuc_L-PSP PF01042.21 CCF53772.1 - 2.1e-40 137.5 0.2 2.4e-40 137.3 0.2 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP Rota_NSP3 PF01665.16 CCF53772.1 - 0.068 12.3 0.0 0.083 12.0 0.0 1.1 1 0 0 1 1 1 0 Rotavirus non-structural protein NSP3 SET PF00856.28 CCF53773.1 - 0.0046 17.4 1.5 1.8 9.0 1.5 3.6 1 1 0 1 1 1 1 SET domain NPR3 PF03666.13 CCF53773.1 - 0.13 11.1 0.3 0.2 10.4 0.3 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 EIF4E-T PF10477.9 CCF53773.1 - 3.4 6.4 9.2 4.9 5.8 9.2 1.1 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E BUD22 PF09073.10 CCF53773.1 - 8 5.7 22.9 16 4.7 22.9 1.5 1 1 0 1 1 1 0 BUD22 SDA1 PF05285.12 CCF53773.1 - 8.2 5.7 23.8 0.18 11.2 16.9 1.6 2 0 0 2 2 2 0 SDA1 zf-UBR PF02207.20 CCF53774.1 - 5.7e-17 61.6 15.3 5.7e-17 61.6 15.3 2.3 2 0 0 2 2 2 1 Putative zinc finger in N-recognin (UBR box) ClpS PF02617.17 CCF53774.1 - 4.6e-10 39.2 0.0 1.5e-09 37.5 0.0 1.9 1 0 0 1 1 1 1 ATP-dependent Clp protease adaptor protein ClpS PBP1_TM PF14812.6 CCF53774.1 - 2.6 8.5 7.9 1.2 9.5 1.3 2.9 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Fungal_trans PF04082.18 CCF53777.1 - 2e-13 50.0 0.0 4.4e-13 48.9 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF53777.1 - 1.1e-06 28.7 8.1 1.8e-06 28.0 8.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain VirionAssem_T7 PF11653.8 CCF53777.1 - 4.2 8.0 6.6 1 9.9 2.0 2.2 2 0 0 2 2 2 0 Bacteriophage T7 virion assembly protein ICE2 PF08426.10 CCF53778.1 - 7.2e-60 203.2 14.8 9.1e-34 117.2 4.6 3.2 2 1 0 2 2 2 2 ICE2 DS PF01916.17 CCF53780.1 - 2.2e-132 440.6 0.0 2.6e-132 440.4 0.0 1.0 1 0 0 1 1 1 1 Deoxyhypusine synthase DUF494 PF04361.13 CCF53780.1 - 0.0068 16.3 0.0 0.011 15.6 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF494) Abhydrolase_5 PF12695.7 CCF53781.1 - 0.0046 16.7 0.0 0.0098 15.7 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family Lipase_3 PF01764.25 CCF53781.1 - 0.076 12.9 0.0 0.18 11.7 0.0 1.6 1 0 0 1 1 1 0 Lipase (class 3) AF-4 PF05110.13 CCF53781.1 - 0.9 7.5 7.9 1.2 7.2 7.9 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein EXS PF03124.14 CCF53782.1 - 4.1e-107 358.3 0.1 4.8e-107 358.1 0.1 1.0 1 0 0 1 1 1 1 EXS family DUF775 PF05603.12 CCF53783.1 - 1.5e-48 165.0 0.0 1.7e-48 164.9 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF775) Nop16 PF09420.10 CCF53784.1 - 2.2e-56 191.2 4.7 2.6e-56 191.0 4.7 1.0 1 0 0 1 1 1 1 Ribosome biogenesis protein Nop16 Glyco_trans_4_3 PF12000.8 CCF53784.1 - 0.061 13.0 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase family 4 group MoaC PF01967.21 CCF53785.1 - 3.6e-50 169.6 0.1 5.8e-50 168.9 0.1 1.3 1 0 0 1 1 1 1 MoaC family Radical_SAM PF04055.21 CCF53785.1 - 2e-27 96.6 0.0 3.7e-27 95.7 0.0 1.4 1 0 0 1 1 1 1 Radical SAM superfamily Mob_synth_C PF06463.13 CCF53785.1 - 6.3e-19 68.2 0.1 6.3e-18 64.9 0.0 2.6 2 1 0 2 2 2 1 Molybdenum Cofactor Synthesis C Fer4_12 PF13353.6 CCF53785.1 - 2.4e-07 31.1 0.0 1.1e-06 28.9 0.0 2.0 2 0 0 2 2 2 1 4Fe-4S single cluster domain Fer4_14 PF13394.6 CCF53785.1 - 0.00017 21.7 0.0 0.0015 18.7 0.0 2.4 2 0 0 2 2 2 1 4Fe-4S single cluster domain Host_attach PF10116.9 CCF53785.1 - 0.25 11.9 2.3 0.54 10.8 2.3 1.5 1 0 0 1 1 1 0 Protein required for attachment to host cells Xan_ur_permease PF00860.20 CCF53786.1 - 8.7e-59 199.2 28.5 8.7e-59 199.2 28.5 1.7 2 0 0 2 2 2 1 Permease family DUF2627 PF11118.8 CCF53786.1 - 0.14 12.7 2.2 0.74 10.4 0.4 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2627) MFS_MOT1 PF16983.5 CCF53786.1 - 4.2 7.8 21.2 0.052 13.9 2.5 4.1 4 0 0 4 4 4 0 Molybdate transporter of MFS superfamily VPS13_C PF16909.5 CCF53787.1 - 0.019 14.7 4.3 0.019 14.7 4.3 1.8 1 1 1 2 2 2 0 Vacuolar-sorting-associated 13 protein C-terminal SprA-related PF12118.8 CCF53787.1 - 6 5.9 21.0 7.7 5.5 21.0 1.1 1 0 0 1 1 1 0 SprA-related family Lyase_aromatic PF00221.19 CCF53789.1 - 1.1e-146 489.2 3.6 1.7e-146 488.6 3.6 1.2 1 0 0 1 1 1 1 Aromatic amino acid lyase Frigida PF07899.11 CCF53789.1 - 0.03 13.6 0.1 0.78 8.9 0.1 2.2 2 0 0 2 2 2 0 Frigida-like protein Hydantoinase_B PF02538.14 CCF53790.1 - 1e-211 703.8 0.3 1.2e-211 703.6 0.3 1.0 1 0 0 1 1 1 1 Hydantoinase B/oxoprolinase Proteasome_A_N PF10584.9 CCF53790.1 - 0.3 10.8 1.0 0.49 10.1 0.0 1.9 2 0 0 2 2 2 0 Proteasome subunit A N-terminal signature Form_Nir_trans PF01226.17 CCF53793.1 - 3.6e-63 213.0 20.3 4.2e-63 212.8 20.3 1.0 1 0 0 1 1 1 1 Formate/nitrite transporter HECT PF00632.25 CCF53794.1 - 8.5e-34 117.4 0.0 1.8e-18 67.1 0.0 2.2 2 0 0 2 2 2 2 HECT-domain (ubiquitin-transferase) Hydrolase_4 PF12146.8 CCF53795.1 - 2.5e-38 131.7 0.1 3.3e-22 78.9 0.0 2.2 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 CCF53795.1 - 2.1e-08 34.1 0.1 1.2e-05 25.1 0.1 2.4 2 1 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CCF53795.1 - 1.4e-05 25.8 0.8 2.3e-05 25.1 0.8 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S15 PF02129.18 CCF53795.1 - 0.023 14.3 0.0 7.4 6.1 0.0 2.5 2 1 0 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) Peptidase_S9 PF00326.21 CCF53795.1 - 0.03 13.8 0.0 0.96 8.9 0.0 2.3 2 0 0 2 2 2 0 Prolyl oligopeptidase family RRF PF01765.19 CCF53796.1 - 9.5e-39 133.0 0.1 1.4e-38 132.4 0.1 1.2 1 0 0 1 1 1 1 Ribosome recycling factor TRAM_LAG1_CLN8 PF03798.16 CCF53797.1 - 6.3e-30 104.4 9.1 8.1e-30 104.0 9.1 1.1 1 0 0 1 1 1 1 TLC domain Smr PF01713.21 CCF53798.1 - 2.5e-07 30.9 1.6 5.8e-07 29.8 0.0 2.4 3 0 0 3 3 3 1 Smr domain DUF1771 PF08590.10 CCF53798.1 - 0.0069 16.7 0.8 0.0069 16.7 0.8 2.7 2 1 0 2 2 2 1 Domain of unknown function (DUF1771) CUE PF02845.16 CCF53798.1 - 0.013 15.2 1.2 0.76 9.6 0.0 3.3 4 0 0 4 4 4 0 CUE domain Abhydrolase_6 PF12697.7 CCF53799.1 - 0.00036 21.2 0.5 0.00056 20.6 0.5 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 CCF53799.1 - 0.0038 16.9 0.1 0.018 14.7 0.1 1.8 2 0 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CCF53799.1 - 0.021 14.1 0.0 0.05 12.9 0.0 1.5 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Oxidored-like PF09791.9 CCF53800.1 - 9.8e-08 31.6 10.1 1.6e-07 30.9 10.1 1.3 1 0 0 1 1 1 1 Oxidoreductase-like protein, N-terminal DUF5535 PF17687.1 CCF53800.1 - 0.095 12.9 0.4 0.14 12.3 0.4 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5535) adh_short_C2 PF13561.6 CCF53802.1 - 1.3e-54 185.2 3.8 2.2e-54 184.5 3.8 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCF53802.1 - 5.5e-44 150.0 1.1 5.5e-44 150.0 1.1 1.5 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.10 CCF53802.1 - 5.3e-07 29.7 2.2 1.6e-06 28.2 2.2 1.7 1 1 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 CCF53802.1 - 0.011 14.9 0.0 0.019 14.1 0.0 1.4 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein ThiF PF00899.21 CCF53802.1 - 0.08 12.3 0.8 0.3 10.4 0.1 2.0 1 1 1 2 2 2 0 ThiF family UPRTase PF14681.6 CCF53803.1 - 4.7e-70 235.3 0.0 5.3e-70 235.1 0.0 1.0 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Pribosyltran PF00156.27 CCF53803.1 - 0.0017 17.9 0.0 0.0025 17.3 0.0 1.2 1 0 0 1 1 1 1 Phosphoribosyl transferase domain MFS_1 PF07690.16 CCF53804.1 - 4.9e-21 75.0 46.6 2.3e-15 56.4 23.6 2.6 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF53804.1 - 4.3e-18 65.4 22.7 3.1e-17 62.6 6.4 2.6 2 1 0 2 2 2 2 Sugar (and other) transporter Nodulin_late PF07127.11 CCF53804.1 - 0.0076 16.6 0.2 0.11 12.9 0.0 2.3 2 0 0 2 2 2 1 Late nodulin protein DJ-1_PfpI PF01965.24 CCF53805.1 - 1.1e-11 44.8 0.0 2e-11 44.0 0.0 1.5 1 1 0 1 1 1 1 DJ-1/PfpI family ThiJ_like PF17124.5 CCF53805.1 - 1.3e-06 28.3 0.0 5.5e-06 26.2 0.0 1.8 1 1 0 1 1 1 1 ThiJ/PfpI family-like Catalase_C PF18011.1 CCF53805.1 - 0.074 12.7 0.0 0.1 12.3 0.0 1.3 1 0 0 1 1 1 0 C-terminal domain found in long catalases adh_short PF00106.25 CCF53806.1 - 1.4e-42 145.4 0.0 1.8e-42 145.0 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF53806.1 - 1.4e-20 73.9 0.0 1.8e-20 73.5 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF53806.1 - 1.3e-10 41.5 0.0 1.7e-10 41.1 0.0 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CCF53806.1 - 0.00031 20.3 0.0 0.00047 19.7 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 CCF53806.1 - 0.012 14.8 0.0 0.015 14.4 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein GDP_Man_Dehyd PF16363.5 CCF53806.1 - 0.021 14.3 0.0 0.031 13.7 0.0 1.3 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Sacchrp_dh_NADP PF03435.18 CCF53806.1 - 0.046 14.0 0.0 0.076 13.3 0.0 1.3 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain 3HCDH_N PF02737.18 CCF53806.1 - 0.056 13.3 0.0 0.14 12.1 0.0 1.6 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain TrkA_N PF02254.18 CCF53806.1 - 0.079 13.2 0.0 0.16 12.2 0.0 1.4 1 0 0 1 1 1 0 TrkA-N domain F420_oxidored PF03807.17 CCF53806.1 - 0.11 13.1 0.0 0.25 12.0 0.0 1.6 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Zip PF02535.22 CCF53807.1 - 1.6e-60 205.1 9.0 1.8e-60 204.9 9.0 1.0 1 0 0 1 1 1 1 ZIP Zinc transporter HTH_23 PF13384.6 CCF53808.1 - 2.3e-07 30.4 0.0 0.018 14.8 0.0 2.2 2 0 0 2 2 2 2 Homeodomain-like domain Sigma70_r4_2 PF08281.12 CCF53808.1 - 9.9e-06 25.1 0.0 0.034 13.8 0.0 2.2 2 0 0 2 2 2 2 Sigma-70, region 4 Terminase_5 PF06056.12 CCF53808.1 - 0.0024 17.7 0.4 0.068 13.1 0.0 2.3 2 0 0 2 2 2 1 Putative ATPase subunit of terminase (gpP-like) GerE PF00196.19 CCF53808.1 - 0.014 14.9 0.1 0.61 9.7 0.1 2.2 2 0 0 2 2 2 0 Bacterial regulatory proteins, luxR family HTH_28 PF13518.6 CCF53808.1 - 0.053 13.7 0.0 0.11 12.6 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_Tnp_ISL3 PF13542.6 CCF53808.1 - 0.092 12.2 0.0 0.25 10.8 0.0 1.7 2 0 0 2 2 2 0 Helix-turn-helix domain of transposase family ISL3 Glycos_trans_3N PF02885.17 CCF53808.1 - 0.095 12.6 0.1 0.19 11.6 0.1 1.4 1 0 0 1 1 1 0 Glycosyl transferase family, helical bundle domain RPA_C PF08784.11 CCF53808.1 - 0.11 13.2 0.0 0.19 12.4 0.0 1.4 1 0 0 1 1 1 0 Replication protein A C terminal DUF4272 PF14094.6 CCF53808.1 - 0.14 11.3 0.0 2 7.6 0.0 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4272) HTH_23 PF13384.6 CCF53809.1 - 6e-07 29.1 0.1 1e-06 28.4 0.1 1.3 1 0 0 1 1 1 1 Homeodomain-like domain HTH_29 PF13551.6 CCF53809.1 - 6.1e-05 23.0 0.5 0.00011 22.2 0.0 1.6 2 0 0 2 2 2 1 Winged helix-turn helix MarR_2 PF12802.7 CCF53809.1 - 0.0001 22.1 0.1 0.00014 21.7 0.1 1.2 1 0 0 1 1 1 1 MarR family HTH_38 PF13936.6 CCF53809.1 - 0.00051 19.7 0.2 0.00082 19.1 0.2 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_28 PF13518.6 CCF53809.1 - 0.0011 19.0 0.0 0.002 18.2 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_Tnp_IS1 PF12759.7 CCF53809.1 - 0.0011 18.5 0.1 0.0018 17.9 0.1 1.3 1 0 0 1 1 1 1 InsA C-terminal domain AAA_30 PF13604.6 CCF53809.1 - 0.0017 18.1 0.1 0.0022 17.7 0.1 1.1 1 0 0 1 1 1 1 AAA domain Crp PF00325.20 CCF53809.1 - 0.0019 17.8 0.1 0.003 17.2 0.1 1.3 1 0 0 1 1 1 1 Bacterial regulatory proteins, crp family GerE PF00196.19 CCF53809.1 - 0.0022 17.5 0.1 0.0038 16.8 0.1 1.4 1 0 0 1 1 1 1 Bacterial regulatory proteins, luxR family Sigma70_r4_2 PF08281.12 CCF53809.1 - 0.0038 16.9 0.1 0.006 16.2 0.1 1.3 1 0 0 1 1 1 1 Sigma-70, region 4 HTH_Tnp_1 PF01527.20 CCF53809.1 - 0.013 15.8 0.0 0.024 14.9 0.0 1.4 1 0 0 1 1 1 0 Transposase CENP-B_N PF04218.13 CCF53809.1 - 0.016 14.9 0.7 0.026 14.2 0.7 1.4 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain HTH_Crp_2 PF13545.6 CCF53809.1 - 0.02 14.9 0.1 0.03 14.3 0.1 1.3 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain TrmB PF01978.19 CCF53809.1 - 0.047 13.6 0.0 0.069 13.0 0.0 1.3 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB HTH_7 PF02796.15 CCF53809.1 - 0.049 13.7 0.1 0.12 12.5 0.1 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain of resolvase HTH_32 PF13565.6 CCF53809.1 - 0.062 13.9 0.3 0.14 12.8 0.1 1.7 1 1 0 1 1 1 0 Homeodomain-like domain TnsD PF15978.5 CCF53809.1 - 0.081 11.9 0.1 0.096 11.7 0.1 1.1 1 0 0 1 1 1 0 Tn7-like transposition protein D Sigma70_ECF PF07638.11 CCF53809.1 - 0.095 12.6 0.1 0.14 12.1 0.1 1.2 1 0 0 1 1 1 0 ECF sigma factor HTH_38 PF13936.6 CCF53810.1 - 7.7e-05 22.4 0.0 0.00015 21.4 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_23 PF13384.6 CCF53810.1 - 0.00013 21.6 0.1 0.00022 20.9 0.1 1.4 1 0 0 1 1 1 1 Homeodomain-like domain GerE PF00196.19 CCF53810.1 - 0.0045 16.5 0.0 0.0081 15.7 0.0 1.4 1 0 0 1 1 1 1 Bacterial regulatory proteins, luxR family Sigma70_r4_2 PF08281.12 CCF53810.1 - 0.013 15.1 0.0 0.023 14.4 0.0 1.4 1 0 0 1 1 1 0 Sigma-70, region 4 HTH_32 PF13565.6 CCF53810.1 - 0.049 14.3 0.2 0.049 14.3 0.2 2.5 2 1 1 3 3 3 0 Homeodomain-like domain Terminase_5 PF06056.12 CCF53810.1 - 0.2 11.5 0.0 0.45 10.4 0.0 1.5 1 0 0 1 1 1 0 Putative ATPase subunit of terminase (gpP-like) DUF3760 PF12586.8 CCF53811.1 - 0.00024 21.2 1.6 0.00024 21.2 1.6 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF3760) F-box-like PF12937.7 CCF53811.1 - 0.00043 20.1 1.0 0.00089 19.1 1.0 1.6 1 0 0 1 1 1 1 F-box-like Ytp1 PF10355.9 CCF53812.1 - 9.8e-58 195.5 18.0 1.6e-30 106.3 0.1 2.3 1 1 1 2 2 2 2 Protein of unknown function (Ytp1) DUF2427 PF10348.9 CCF53812.1 - 2e-28 98.2 2.8 2e-28 98.2 2.8 2.9 3 0 0 3 3 3 1 Domain of unknown function (DUF2427) CTP_transf_like PF01467.26 CCF53813.1 - 1.2e-24 87.2 0.0 2.2e-24 86.3 0.0 1.5 1 0 0 1 1 1 1 Cytidylyltransferase-like GEN1_C PF18380.1 CCF53813.1 - 0.41 11.6 3.3 0.56 11.1 1.0 2.5 2 0 0 2 2 2 0 Holliday junction resolvase Gen1 C-terminal domain MMtag PF10159.9 CCF53814.1 - 8.1e-28 96.5 1.5 8.1e-28 96.5 1.5 3.4 2 1 0 2 2 2 1 Multiple myeloma tumor-associated IMS PF00817.20 CCF53815.1 - 2.8e-36 124.8 0.0 4.9e-36 124.0 0.0 1.4 1 0 0 1 1 1 1 impB/mucB/samB family IMS_C PF11799.8 CCF53815.1 - 1.7e-07 31.9 0.0 3.8e-07 30.8 0.0 1.6 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain zf_UBZ PF18439.1 CCF53815.1 - 0.0001 21.8 1.9 0.0015 18.1 0.3 2.4 2 0 0 2 2 2 1 Ubiquitin-Binding Zinc Finger TIR-like PF10137.9 CCF53815.1 - 0.13 12.3 0.0 1.9 8.5 0.0 2.2 2 0 0 2 2 2 0 Predicted nucleotide-binding protein containing TIR-like domain Glyco_hydro_cc PF11790.8 CCF53816.1 - 7.9e-68 228.6 9.0 9.4e-68 228.3 9.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase catalytic core Glyco_hydro_39 PF01229.17 CCF53816.1 - 0.013 14.1 0.0 0.019 13.6 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolases family 39 Glyco_hydro_2_C PF02836.17 CCF53816.1 - 0.081 12.0 0.0 0.12 11.5 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolases family 2, TIM barrel domain Aldo_ket_red PF00248.21 CCF53816.1 - 0.13 11.4 0.0 0.16 11.2 0.0 1.2 1 0 0 1 1 1 0 Aldo/keto reductase family MFS_1 PF07690.16 CCF53817.1 - 2e-20 73.0 44.0 4.2e-11 42.4 21.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Neurensin PF14927.6 CCF53817.1 - 1.7 8.4 5.1 0.66 9.7 0.1 2.9 4 0 0 4 4 4 0 Neurensin Alpha-amylase PF00128.24 CCF53818.1 - 1.3e-11 44.7 0.0 2.7e-11 43.7 0.0 1.5 2 0 0 2 2 2 1 Alpha amylase, catalytic domain Cu-oxidase_2 PF07731.14 CCF53820.1 - 9.1e-42 142.0 3.8 2.4e-39 134.2 0.5 3.4 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase PF00394.22 CCF53820.1 - 8.4e-38 130.0 0.9 1.2e-34 119.7 0.0 2.9 4 0 0 4 4 4 2 Multicopper oxidase Cu-oxidase_3 PF07732.15 CCF53820.1 - 3.8e-30 104.3 0.7 9.9e-26 90.1 0.1 3.8 3 0 0 3 3 3 2 Multicopper oxidase FTR1 PF03239.14 CCF53821.1 - 2.9e-52 177.7 14.1 5.5e-34 117.7 7.4 2.2 2 0 0 2 2 2 2 Iron permease FTR1 family Wzy_C PF04932.15 CCF53821.1 - 0.0099 15.5 4.2 0.74 9.4 1.4 2.5 2 0 0 2 2 2 2 O-Antigen ligase DUF3341 PF11821.8 CCF53821.1 - 0.12 12.1 0.4 1.1 8.9 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3341) DUF2142 PF09913.9 CCF53821.1 - 2.9 6.6 9.2 0.18 10.6 0.6 2.4 2 1 0 3 3 3 0 Predicted membrane protein (DUF2142) TMEM208_SND2 PF05620.11 CCF53821.1 - 3.4 7.4 7.2 0.46 10.2 1.7 2.3 2 1 0 2 2 2 0 SRP-independent targeting protein 2/TMEM208 Phage_holin_3_6 PF07332.11 CCF53821.1 - 4.6 7.3 17.7 0.05 13.7 1.1 2.9 3 0 0 3 3 3 0 Putative Actinobacterial Holin-X, holin superfamily III ATP-synt_S1 PF05827.12 CCF53822.1 - 0.15 11.9 0.0 0.37 10.6 0.0 1.6 1 0 0 1 1 1 0 Vacuolar ATP synthase subunit S1 (ATP6S1) DUF4148 PF13663.6 CCF53822.1 - 5.2 7.3 7.5 7.2 6.9 4.7 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4148) adh_short_C2 PF13561.6 CCF53823.1 - 7.5e-62 208.9 0.2 1e-61 208.5 0.2 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCF53823.1 - 1.1e-46 158.7 0.5 1.7e-46 158.2 0.5 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CCF53823.1 - 2.9e-13 50.1 0.1 4.7e-13 49.4 0.1 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CCF53823.1 - 0.00049 19.6 0.0 0.0011 18.4 0.0 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 CCF53823.1 - 0.018 14.2 0.2 0.025 13.7 0.2 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Dak1 PF02733.17 CCF53824.1 - 7.8e-103 343.6 0.0 1.1e-102 343.2 0.0 1.2 1 0 0 1 1 1 1 Dak1 domain Dak2 PF02734.17 CCF53824.1 - 1.7e-44 151.8 0.6 3.5e-44 150.7 0.6 1.6 1 0 0 1 1 1 1 DAK2 domain DUF1769 PF08588.10 CCF53825.1 - 8.5e-17 61.1 0.6 1.5e-16 60.3 0.6 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1769) Mpv17_PMP22 PF04117.12 CCF53826.1 - 1.1e-05 25.6 5.1 7.8e-05 22.8 3.4 2.2 1 1 1 2 2 2 1 Mpv17 / PMP22 family MatE PF01554.18 CCF53826.1 - 0.019 14.7 3.1 0.3 10.7 0.2 2.4 1 1 1 2 2 2 0 MatE Prp19 PF08606.11 CCF53827.1 - 6.3e-31 106.2 2.0 1.1e-30 105.4 2.0 1.4 1 0 0 1 1 1 1 Prp19/Pso4-like WD40 PF00400.32 CCF53827.1 - 2.3e-28 97.8 2.8 0.0025 18.6 0.0 7.8 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF53827.1 - 5e-17 62.0 0.5 0.00047 20.4 0.0 5.2 2 1 3 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain zf-Nse PF11789.8 CCF53827.1 - 0.01 15.7 0.0 0.017 14.9 0.0 1.3 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit U-box PF04564.15 CCF53827.1 - 0.023 14.9 0.0 0.052 13.7 0.0 1.6 1 0 0 1 1 1 0 U-box domain Ge1_WD40 PF16529.5 CCF53827.1 - 0.087 11.8 0.5 13 4.7 0.0 2.9 2 1 0 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Fungal_trans PF04082.18 CCF53828.1 - 2.1e-28 99.1 0.0 3.7e-28 98.3 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF53828.1 - 1.1e-11 44.7 9.0 1.8e-11 44.0 9.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF1295 PF06966.12 CCF53828.1 - 0.13 11.7 0.0 0.21 11.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1295) TFIID-18kDa PF02269.16 CCF53829.1 - 3.1e-29 100.8 1.1 9.8e-29 99.2 0.5 2.0 2 0 0 2 2 2 1 Transcription initiation factor IID, 18kD subunit TFIIE-A_C PF11521.8 CCF53829.1 - 0.048 14.0 0.5 0.048 14.0 0.5 3.0 2 1 0 2 2 2 0 C-terminal general transcription factor TFIIE alpha Hid1 PF12722.7 CCF53829.1 - 0.84 7.7 5.4 1.5 6.9 5.4 1.3 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein PPP4R2 PF09184.11 CCF53829.1 - 3.9 7.0 14.1 2.9 7.4 6.0 2.1 2 0 0 2 2 2 0 PPP4R2 ADH_zinc_N PF00107.26 CCF53830.1 - 1.7e-10 41.0 0.5 1.2e-09 38.2 0.4 2.2 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CCF53830.1 - 3.1e-05 25.0 0.1 7.5e-05 23.8 0.0 1.6 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CCF53830.1 - 3.6e-05 23.6 0.0 6.9e-05 22.7 0.0 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Aminotran_4 PF01063.19 CCF53831.1 - 1.3e-25 90.6 0.0 1.9e-25 90.1 0.0 1.2 1 0 0 1 1 1 1 Amino-transferase class IV MFS_1 PF07690.16 CCF53832.1 - 9.2e-30 103.7 32.6 1.5e-29 103.1 32.6 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF2530 PF10745.9 CCF53832.1 - 0.67 10.2 5.9 0.52 10.6 0.2 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2530) Amidase PF01425.21 CCF53833.1 - 8.3e-79 265.6 0.0 2.7e-61 207.9 0.0 2.0 1 1 0 2 2 2 2 Amidase EutA PF06277.11 CCF53833.1 - 0.0076 15.1 0.0 0.013 14.3 0.0 1.3 1 0 0 1 1 1 1 Ethanolamine utilisation protein EutA UPA_2 PF17809.1 CCF53833.1 - 0.16 11.8 0.0 0.32 10.8 0.0 1.5 1 0 0 1 1 1 0 UPA domain UDPG_MGDP_dh_N PF03721.14 CCF53834.1 - 1.6e-59 200.6 0.1 3.3e-58 196.3 0.0 2.3 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain UDPG_MGDP_dh_C PF03720.15 CCF53834.1 - 1.7e-33 115.2 0.2 9.2e-33 112.8 0.1 2.2 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain UDPG_MGDP_dh PF00984.19 CCF53834.1 - 9.6e-32 109.1 0.1 2.6e-31 107.7 0.0 1.8 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain F420_oxidored PF03807.17 CCF53834.1 - 0.0009 19.8 0.1 0.81 10.3 0.1 2.8 2 0 0 2 2 2 2 NADP oxidoreductase coenzyme F420-dependent NAD_binding_2 PF03446.15 CCF53834.1 - 0.0022 18.2 0.1 0.54 10.4 0.0 2.5 2 0 0 2 2 2 2 NAD binding domain of 6-phosphogluconate dehydrogenase PG_binding_1 PF01471.18 CCF53835.1 - 0.01 16.0 0.0 0.022 15.0 0.0 1.5 1 0 0 1 1 1 0 Putative peptidoglycan binding domain Metallophos PF00149.28 CCF53835.1 - 0.022 15.3 0.0 0.074 13.5 0.0 1.9 1 1 0 1 1 1 0 Calcineurin-like phosphoesterase SpoIIE PF07228.12 CCF53836.1 - 7.3e-13 48.9 0.0 1.1e-12 48.3 0.0 1.3 1 0 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) PP2C PF00481.21 CCF53836.1 - 0.00044 20.0 0.0 0.053 13.1 0.0 2.3 1 1 1 2 2 2 2 Protein phosphatase 2C DUF1770 PF08589.10 CCF53837.1 - 2.2e-07 31.8 0.9 2.2e-07 31.8 0.9 2.1 1 1 1 2 2 2 1 Fungal protein of unknown function (DUF1770) WI12 PF07107.11 CCF53837.1 - 0.054 13.6 0.1 0.15 12.2 0.0 1.7 2 0 0 2 2 2 0 Wound-induced protein WI12 AidB_N PF18158.1 CCF53838.1 - 8.1e-19 68.1 0.0 1.5e-18 67.2 0.0 1.4 1 0 0 1 1 1 1 Adaptive response protein AidB N-terminal domain Acyl-CoA_dh_1 PF00441.24 CCF53838.1 - 6.9e-15 55.6 0.8 5.2e-14 52.7 0.1 2.5 3 0 0 3 3 3 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 CCF53838.1 - 1.4e-13 50.8 0.0 2.6e-13 50.0 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 CCF53838.1 - 0.06 14.0 0.1 0.3 11.8 0.0 2.3 2 0 0 2 2 2 0 Acyl-CoA dehydrogenase, N-terminal domain FMN_dh PF01070.18 CCF53839.1 - 1.9e-116 388.9 0.1 2.4e-116 388.6 0.1 1.1 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Cyt-b5 PF00173.28 CCF53839.1 - 2e-16 59.9 0.0 4e-16 58.9 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Glu_synthase PF01645.17 CCF53839.1 - 1.4e-05 24.4 0.0 2.3e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 Conserved region in glutamate synthase IMPDH PF00478.25 CCF53839.1 - 0.00018 20.6 0.3 0.00074 18.6 0.3 1.8 1 1 1 2 2 2 1 IMP dehydrogenase / GMP reductase domain DHO_dh PF01180.21 CCF53839.1 - 0.049 12.8 0.0 0.07 12.3 0.0 1.2 1 0 0 1 1 1 0 Dihydroorotate dehydrogenase Usp PF00582.26 CCF53841.1 - 2.3e-19 70.3 0.9 3.3e-19 69.8 0.9 1.2 1 0 0 1 1 1 1 Universal stress protein family CLP_protease PF00574.23 CCF53841.1 - 0.055 13.3 0.0 0.084 12.7 0.0 1.2 1 0 0 1 1 1 0 Clp protease Polysacc_deac_1 PF01522.21 CCF53842.1 - 1.3e-13 50.9 0.0 2.6e-13 50.0 0.0 1.4 1 0 0 1 1 1 1 Polysaccharide deacetylase GFA PF04828.14 CCF53842.1 - 3.7e-08 33.6 0.9 5.4e-06 26.7 0.9 2.4 1 1 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme Mss4 PF04421.13 CCF53843.1 - 8.2e-08 32.3 5.5 0.045 13.9 0.0 3.2 2 1 0 2 2 2 2 Mss4 protein Acetyltransf_1 PF00583.25 CCF53843.1 - 1.2e-06 28.7 0.0 3.8e-06 27.1 0.0 1.8 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 CCF53843.1 - 1.1e-05 25.8 0.0 2.1e-05 24.8 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 CCF53843.1 - 0.0028 17.6 0.1 0.033 14.1 0.1 2.2 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain SART-1 PF03343.13 CCF53843.1 - 0.015 13.9 8.4 0.026 13.1 8.4 1.3 1 0 0 1 1 1 0 SART-1 family Acetyltransf_9 PF13527.7 CCF53843.1 - 0.041 14.0 0.0 0.1 12.7 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Casc1_N PF15927.5 CCF53843.1 - 0.057 13.1 5.3 0.095 12.4 5.3 1.4 1 0 0 1 1 1 0 Cancer susceptibility candidate 1 N-terminus DDHD PF02862.17 CCF53843.1 - 0.063 13.4 3.5 7.1 6.7 0.1 2.9 3 0 0 3 3 3 0 DDHD domain FR47 PF08445.10 CCF53843.1 - 0.16 12.0 0.0 0.97 9.4 0.0 2.1 2 0 0 2 2 2 0 FR47-like protein NARP1 PF12569.8 CCF53843.1 - 1.9 7.3 9.2 3.6 6.4 9.2 1.3 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Cellulase PF00150.18 CCF53844.1 - 2.2e-15 56.8 0.2 3.7e-15 56.1 0.2 1.3 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Abhydrolase_3 PF07859.13 CCF53845.1 - 9.8e-10 38.6 0.1 1.4e-09 38.1 0.1 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CCF53845.1 - 6.8e-07 30.1 0.2 7.9e-07 29.9 0.2 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CCF53845.1 - 5.9e-05 22.4 0.0 0.00012 21.5 0.0 1.5 1 0 0 1 1 1 1 Serine aminopeptidase, S33 COesterase PF00135.28 CCF53845.1 - 0.0026 16.7 0.0 0.0038 16.2 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family DUF900 PF05990.12 CCF53845.1 - 0.0058 16.2 0.0 0.04 13.4 0.0 2.0 2 0 0 2 2 2 1 Alpha/beta hydrolase of unknown function (DUF900) Abhydrolase_1 PF00561.20 CCF53845.1 - 0.0067 16.1 0.1 0.0098 15.6 0.1 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold LIDHydrolase PF10230.9 CCF53845.1 - 0.0073 15.9 0.0 0.011 15.3 0.0 1.2 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase Thioesterase PF00975.20 CCF53845.1 - 0.098 12.8 0.0 1.2 9.2 0.0 2.1 2 0 0 2 2 2 0 Thioesterase domain Peptidase_S9 PF00326.21 CCF53845.1 - 0.18 11.2 0.0 0.41 10.1 0.0 1.5 1 1 0 1 1 1 0 Prolyl oligopeptidase family DUF2103 PF09876.9 CCF53846.1 - 0.00068 19.6 0.1 0.0016 18.4 0.1 1.6 1 0 0 1 1 1 1 Predicted metal-binding protein (DUF2103) Abhydrolase_2 PF02230.16 CCF53847.1 - 2.1e-55 187.9 0.0 2.6e-55 187.6 0.0 1.0 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Hydrolase_4 PF12146.8 CCF53847.1 - 5.3e-08 32.4 0.1 0.0097 15.2 0.1 3.1 2 1 1 3 3 3 3 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 CCF53847.1 - 1.7e-06 27.9 0.5 0.0018 18.0 0.1 2.7 2 1 1 3 3 3 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CCF53847.1 - 3.1e-06 28.0 0.4 4.5e-06 27.4 0.4 1.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 CCF53847.1 - 0.0005 19.6 0.1 0.023 14.2 0.0 2.3 2 1 1 3 3 3 1 Prolyl oligopeptidase family Esterase PF00756.20 CCF53847.1 - 0.0012 18.5 0.0 0.0019 17.9 0.0 1.3 1 0 0 1 1 1 1 Putative esterase DLH PF01738.18 CCF53847.1 - 0.0021 17.7 0.0 0.0031 17.1 0.0 1.2 1 0 0 1 1 1 1 Dienelactone hydrolase family FSH1 PF03959.13 CCF53847.1 - 0.0031 17.2 0.0 0.029 14.0 0.0 2.3 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Esterase_phd PF10503.9 CCF53847.1 - 0.012 15.1 0.0 0.72 9.3 0.0 2.2 1 1 1 2 2 2 0 Esterase PHB depolymerase AXE1 PF05448.12 CCF53847.1 - 0.027 13.2 0.0 0.039 12.6 0.0 1.2 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) Abhydrolase_3 PF07859.13 CCF53847.1 - 0.029 14.2 0.2 0.4 10.5 0.1 2.1 1 1 1 2 2 2 0 alpha/beta hydrolase fold Cutinase PF01083.22 CCF53847.1 - 0.094 12.7 0.1 0.39 10.7 0.1 1.8 2 0 0 2 2 2 0 Cutinase ADH_zinc_N PF00107.26 CCF53848.1 - 3.3e-25 88.6 0.4 5.5e-25 87.8 0.4 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CCF53848.1 - 2e-12 48.3 0.0 7.2e-12 46.5 0.0 2.0 1 1 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CCF53848.1 - 7.1e-09 35.5 0.0 1.8e-07 31.0 0.0 2.4 1 1 1 2 2 2 2 Alcohol dehydrogenase GroES-like domain ADH_N_2 PF16884.5 CCF53848.1 - 0.027 14.3 0.0 0.055 13.4 0.0 1.5 1 0 0 1 1 1 0 N-terminal domain of oxidoreductase DUF883 PF05957.13 CCF53849.1 - 2.9e-08 34.2 73.7 0.2 12.3 2.1 8.9 3 3 4 8 8 8 8 Bacterial protein of unknown function (DUF883) Apolipoprotein PF01442.18 CCF53849.1 - 0.0024 17.8 58.8 0.01 15.7 1.7 4.5 1 1 3 4 4 4 3 Apolipoprotein A1/A4/E domain ApoO PF09769.9 CCF53849.1 - 0.058 13.4 0.4 0.058 13.4 0.4 6.0 2 1 3 5 5 5 0 Apolipoprotein O YtxH PF12732.7 CCF53849.1 - 0.44 11.1 87.8 0.14 12.7 3.0 9.4 2 2 0 2 2 2 0 YtxH-like protein DUF1543 PF07566.12 CCF53849.1 - 1.9 8.3 44.7 2.3 8.0 0.5 10.6 9 3 3 12 12 12 0 Domain of Unknown Function (DUF1543) Acetyltransf_3 PF13302.7 CCF53850.1 - 3.2e-17 63.5 0.0 4.4e-17 63.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 CCF53850.1 - 0.00027 20.7 0.7 0.31 10.7 0.0 2.2 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CCF53850.1 - 0.0024 18.3 0.0 0.0039 17.6 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_13 PF13880.6 CCF53850.1 - 0.17 11.9 0.0 26 4.9 0.0 2.3 2 0 0 2 2 2 0 ESCO1/2 acetyl-transferase zf-C2H2 PF00096.26 CCF53851.1 - 4.7e-30 102.4 73.5 0.00036 20.8 0.7 10.6 10 0 0 10 10 10 10 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CCF53851.1 - 8.9e-15 54.1 70.0 0.092 13.6 0.4 10.6 10 0 0 10 10 10 9 C2H2-type zinc finger zf-C2H2_8 PF15909.5 CCF53851.1 - 1.5e-09 38.1 21.4 0.0014 18.9 1.0 5.6 3 1 2 5 5 5 3 C2H2-type zinc ribbon zf-H2C2_2 PF13465.6 CCF53851.1 - 4.9e-08 33.1 3.8 4.8e-05 23.6 0.2 10.3 10 2 0 10 10 10 3 Zinc-finger double domain FOXP-CC PF16159.5 CCF53851.1 - 7.9e-06 26.4 36.2 0.011 16.4 0.7 8.0 6 1 2 8 8 8 2 FOXP coiled-coil domain zf-C2H2_6 PF13912.6 CCF53851.1 - 0.0011 18.9 0.2 0.0011 18.9 0.2 7.3 8 0 0 8 8 8 2 C2H2-type zinc finger zf-H2C2_5 PF13909.6 CCF53851.1 - 0.012 15.3 20.0 3.1 7.6 0.1 7.2 7 0 0 7 7 7 0 C2H2-type zinc-finger domain DUF1059 PF06348.11 CCF53851.1 - 0.012 15.8 0.2 20 5.5 0.0 4.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1059) Flagellin_IN PF07196.13 CCF53851.1 - 0.072 13.3 3.3 0.16 12.2 3.3 1.6 1 0 0 1 1 1 0 Flagellin hook IN motif zf-met PF12874.7 CCF53851.1 - 0.26 11.7 28.9 1.5 9.3 0.0 8.2 10 0 0 10 10 9 0 Zinc-finger of C2H2 type zf-C2H2_aberr PF17017.5 CCF53851.1 - 0.34 11.0 22.6 5.9 7.0 1.1 6.1 5 1 2 7 7 7 0 Aberrant zinc-finger zf_CopZ PF18423.1 CCF53851.1 - 0.4 10.7 7.6 5.1 7.1 1.5 3.5 1 1 2 3 3 3 0 Zinc binding domain zf_ZIC PF18366.1 CCF53851.1 - 2.6 8.2 9.6 3.3 7.9 0.0 4.8 6 0 0 6 6 5 0 Zic proteins zinc finger domain zf-C2H2_jaz PF12171.8 CCF53851.1 - 5.4 7.4 27.4 2.7 8.4 0.1 8.0 9 0 0 9 9 9 0 Zinc-finger double-stranded RNA-binding zf-SNAP50_C PF12251.8 CCF53852.1 - 1.6e-12 47.5 0.0 1.5e-08 34.6 0.0 2.7 3 0 0 3 3 3 2 snRNA-activating protein of 50kDa MW C terminal GTP_EFTU PF00009.27 CCF53853.1 - 6.6e-56 188.9 0.1 9.6e-56 188.4 0.1 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 CCF53853.1 - 5.5e-30 104.0 0.0 1.1e-29 103.0 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 CCF53853.1 - 7.4e-17 61.5 2.4 2.1e-16 60.1 2.4 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 CCF53853.1 - 7.8e-05 22.7 0.1 0.00018 21.6 0.1 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CCF53853.1 - 0.0075 16.2 0.1 0.018 14.9 0.0 1.6 2 0 0 2 2 2 1 RsgA GTPase cobW PF02492.19 CCF53853.1 - 0.01 15.4 0.3 0.022 14.3 0.0 1.6 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain PduV-EutP PF10662.9 CCF53853.1 - 0.083 12.6 0.1 9.9 5.9 0.0 2.4 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation KOW PF00467.29 CCF53854.1 - 4.2e-19 67.8 8.7 1.1e-07 31.6 0.0 6.4 6 0 0 6 6 6 4 KOW motif Spt5_N PF11942.8 CCF53854.1 - 5.2e-19 69.1 17.7 5.2e-19 69.1 17.7 2.8 2 0 0 2 2 2 1 Spt5 transcription elongation factor, acidic N-terminal Spt5-NGN PF03439.13 CCF53854.1 - 3.4e-18 65.3 0.0 6.2e-18 64.5 0.0 1.4 1 0 0 1 1 1 1 Early transcription elongation factor of RNA pol II, NGN section CTD PF12815.7 CCF53854.1 - 1.6e-09 38.2 12.4 4.7e-09 36.7 12.4 1.9 1 0 0 1 1 1 1 Spt5 C-terminal nonapeptide repeat binding Spt4 Dus PF01207.17 CCF53855.1 - 3.1e-46 157.9 0.0 7.9e-46 156.6 0.0 1.6 1 1 0 1 1 1 1 Dihydrouridine synthase (Dus) DHO_dh PF01180.21 CCF53855.1 - 0.007 15.6 0.0 0.011 15.0 0.0 1.3 1 0 0 1 1 1 1 Dihydroorotate dehydrogenase PSRT PF07636.11 CCF53855.1 - 0.083 12.6 0.2 0.19 11.4 0.2 1.6 1 0 0 1 1 1 0 PSRT Spc7 PF08317.11 CCF53856.1 - 6.7e-45 153.3 5.4 1.3e-44 152.3 5.4 1.4 1 0 0 1 1 1 1 Spc7 kinetochore protein Aminotran_3 PF00202.21 CCF53856.1 - 0.019 13.7 0.2 0.15 10.7 0.2 2.0 1 1 0 1 1 1 0 Aminotransferase class-III COG5 PF10392.9 CCF53856.1 - 0.028 14.6 4.3 0.084 13.1 4.3 1.9 1 0 0 1 1 1 0 Golgi transport complex subunit 5 DUF2605 PF10792.9 CCF53856.1 - 0.052 13.5 1.1 0.17 11.8 1.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2605) Spc7_C2 PF15577.6 CCF53856.1 - 0.2 11.8 0.2 1.3 9.1 0.2 2.2 1 1 0 1 1 1 0 Spc7_C2 Phage_TAC_4 PF08748.11 CCF53856.1 - 0.57 10.5 7.5 0.077 13.3 0.7 2.7 1 1 1 2 2 2 0 Phage tail assembly chaperone Atg14 PF10186.9 CCF53856.1 - 0.57 9.2 6.9 0.51 9.4 4.5 2.1 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 KxDL PF10241.9 CCF53856.1 - 1.9 8.8 8.2 7 7.0 2.5 2.9 1 1 1 2 2 2 0 Uncharacterized conserved protein FapA PF03961.13 CCF53856.1 - 6.2 5.3 7.3 1.8 7.1 4.1 1.6 2 0 0 2 2 2 0 Flagellar Assembly Protein A CHCH PF06747.13 CCF53857.1 - 3.8e-06 26.9 1.4 4.8e-06 26.6 1.4 1.1 1 0 0 1 1 1 1 CHCH domain Cmc1 PF08583.10 CCF53857.1 - 0.00027 20.9 1.0 0.00036 20.5 1.0 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like CX9C PF16860.5 CCF53857.1 - 0.048 13.7 0.2 0.073 13.1 0.2 1.3 1 0 0 1 1 1 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, HTH_5 PF01022.20 CCF53857.1 - 0.087 12.7 0.0 0.15 11.9 0.0 1.3 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family Sec61_beta PF03911.16 CCF53858.1 - 9.2e-18 64.0 2.2 1.2e-17 63.7 2.2 1.1 1 0 0 1 1 1 1 Sec61beta family RecQ5 PF06959.11 CCF53858.1 - 0.0071 16.3 1.5 0.0083 16.1 1.5 1.0 1 0 0 1 1 1 1 RecQ helicase protein-like 5 (RecQ5) Fasciclin PF02469.22 CCF53860.1 - 4.9e-23 81.8 0.7 3.1e-16 59.8 0.1 2.4 2 0 0 2 2 2 2 Fasciclin domain SSP160 PF06933.11 CCF53860.1 - 0.062 11.5 14.3 0.081 11.1 14.3 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 DUF2958 PF11171.8 CCF53860.1 - 0.16 12.2 0.0 0.33 11.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2958) YopH_N PF09013.10 CCF53860.1 - 4.4 7.6 8.4 0.59 10.4 0.1 3.4 4 0 0 4 4 4 0 YopH, N-terminal Kdo PF06293.14 CCF53862.1 - 1.3e-06 28.0 0.0 1.6e-05 24.4 0.0 2.1 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.25 CCF53862.1 - 1.3e-06 28.0 0.0 2.1e-06 27.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.23 CCF53862.1 - 2.8e-06 27.4 0.7 0.00025 21.1 0.1 2.7 2 1 1 3 3 3 2 Phosphotransferase enzyme family RIO1 PF01163.22 CCF53862.1 - 0.00014 21.5 0.1 0.016 14.8 0.1 2.6 3 0 0 3 3 3 1 RIO1 family EcKinase PF02958.20 CCF53862.1 - 0.0066 15.8 0.0 0.01 15.2 0.0 1.2 1 0 0 1 1 1 1 Ecdysteroid kinase Pkinase_Tyr PF07714.17 CCF53862.1 - 0.016 14.5 0.0 0.023 14.0 0.0 1.2 1 0 0 1 1 1 0 Protein tyrosine kinase Choline_kinase PF01633.20 CCF53862.1 - 0.23 11.0 0.0 0.38 10.3 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase Pkinase_fungal PF17667.1 CCF53862.1 - 2.2 7.0 3.8 0.49 9.1 0.1 1.7 2 0 0 2 2 2 0 Fungal protein kinase ANAPC5 PF12862.7 CCF53863.1 - 1.6e-10 40.9 3.5 6.2e-10 39.0 0.9 3.2 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 5 TPR_8 PF13181.6 CCF53863.1 - 0.35 11.2 7.2 3.4 8.1 0.0 5.0 4 1 1 5 5 5 0 Tetratricopeptide repeat Prominin PF05478.11 CCF53864.1 - 0.13 10.2 0.2 0.18 9.7 0.2 1.2 1 0 0 1 1 1 0 Prominin DUF948 PF06103.11 CCF53864.1 - 0.27 11.5 0.6 21 5.5 0.0 2.8 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF948) Sec7 PF01369.20 CCF53866.1 - 1.6e-33 115.9 0.2 2.5e-33 115.3 0.2 1.2 1 0 0 1 1 1 1 Sec7 domain PH_9 PF15410.6 CCF53866.1 - 4.8e-13 49.5 0.0 1e-12 48.5 0.0 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain PH PF00169.29 CCF53866.1 - 1.4e-10 41.6 0.0 4.7e-10 39.9 0.0 1.9 1 1 0 1 1 1 1 PH domain PH_6 PF15406.6 CCF53866.1 - 0.0024 18.1 0.0 0.0087 16.3 0.0 1.9 1 0 0 1 1 1 1 Pleckstrin homology domain adh_short PF00106.25 CCF53867.1 - 1.8e-84 282.1 13.6 5.4e-43 146.7 4.1 2.4 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CCF53867.1 - 1.9e-68 230.6 15.3 5e-34 117.9 2.9 3.2 2 2 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase MaoC_dehydratas PF01575.19 CCF53867.1 - 2.1e-33 114.5 0.0 4e-33 113.6 0.0 1.4 1 0 0 1 1 1 1 MaoC like domain KR PF08659.10 CCF53867.1 - 2.1e-31 109.2 6.2 7.5e-16 58.6 0.4 2.3 2 0 0 2 2 2 2 KR domain THF_DHG_CYH_C PF02882.19 CCF53867.1 - 0.00023 20.5 0.2 0.15 11.3 0.1 2.6 2 0 0 2 2 2 2 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain 3HCDH_N PF02737.18 CCF53867.1 - 0.0057 16.5 5.8 0.43 10.4 0.9 2.3 2 0 0 2 2 2 2 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DUF543 PF04418.12 CCF53867.1 - 0.011 15.8 3.4 1.8 8.6 0.2 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF543) Polysacc_synt_2 PF02719.15 CCF53867.1 - 0.015 14.5 1.1 0.033 13.3 0.1 2.0 3 0 0 3 3 3 0 Polysaccharide biosynthesis protein MaoC_dehydrat_N PF13452.6 CCF53867.1 - 0.092 12.9 0.0 9.5 6.4 0.0 2.4 2 0 0 2 2 2 0 N-terminal half of MaoC dehydratase PglL_A PF15864.5 CCF53867.1 - 1.8 8.3 8.2 10 6.0 1.0 2.6 2 0 0 2 2 2 0 Protein glycosylation ligase Retrotran_gag_2 PF14223.6 CCF53869.1 - 0.0039 16.9 0.3 0.011 15.4 0.2 1.8 2 0 0 2 2 2 1 gag-polypeptide of LTR copia-type zf-CCHC_4 PF14392.6 CCF53869.1 - 0.21 11.3 0.2 0.21 11.3 0.2 1.7 2 0 0 2 2 2 0 Zinc knuckle Cation_efflux PF01545.21 CCF53870.1 - 2.1e-43 148.4 4.9 1.8e-42 145.3 4.9 2.0 1 1 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 CCF53870.1 - 2.4e-07 30.8 0.1 7e-07 29.3 0.0 1.8 2 0 0 2 2 2 1 Dimerisation domain of Zinc Transporter SelP_N PF04592.14 CCF53870.1 - 0.14 11.6 7.3 0.25 10.7 7.3 1.4 1 0 0 1 1 1 0 Selenoprotein P, N terminal region PH PF00169.29 CCF53871.1 - 4.4e-36 123.6 1.0 2e-19 70.1 0.9 3.3 3 0 0 3 3 3 3 PH domain PH_3 PF14593.6 CCF53871.1 - 5e-19 68.3 4.1 9.8e-09 35.3 1.1 3.2 3 0 0 3 3 3 3 PH domain PH_11 PF15413.6 CCF53871.1 - 1.7e-14 54.1 11.2 1.9e-06 28.3 6.4 4.3 3 1 0 3 3 3 2 Pleckstrin homology domain PH_8 PF15409.6 CCF53871.1 - 5.5e-12 45.8 3.1 1.9e-07 31.3 1.2 2.6 3 0 0 3 3 3 2 Pleckstrin homology domain PH_15 PF17339.2 CCF53871.1 - 7.3e-05 22.6 1.1 0.011 15.7 0.4 2.3 2 0 0 2 2 2 1 PH domain PH_9 PF15410.6 CCF53871.1 - 0.00037 20.9 1.5 0.17 12.2 1.0 3.6 3 1 0 3 3 3 1 Pleckstrin homology domain Mcp5_PH PF12814.7 CCF53871.1 - 0.0053 16.9 0.1 2.6 8.2 0.1 2.6 2 0 0 2 2 2 2 Meiotic cell cortex C-terminal pleckstrin homology PH_13 PF16652.5 CCF53871.1 - 0.0063 16.3 0.5 0.22 11.3 0.3 2.3 2 0 0 2 2 2 1 Pleckstrin homology domain PH_4 PF15404.6 CCF53871.1 - 0.051 13.4 0.8 21 4.8 0.1 3.2 2 1 0 3 3 3 0 Pleckstrin homology domain ESSS PF10183.9 CCF53872.1 - 1.3e-10 41.4 0.1 1.7e-10 41.0 0.1 1.2 1 0 0 1 1 1 1 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) COesterase PF00135.28 CCF53873.1 - 8.3e-71 239.4 0.2 1.8e-70 238.3 0.2 1.4 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 CCF53873.1 - 1.2e-09 38.3 0.2 4.9e-09 36.4 0.2 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 CCF53873.1 - 0.00027 20.5 0.7 0.00065 19.2 0.7 1.6 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_6 PF12697.7 CCF53873.1 - 0.014 16.0 0.3 0.014 16.0 0.3 2.1 3 0 0 3 3 3 0 Alpha/beta hydrolase family zf-AN1 PF01428.16 CCF53874.1 - 7.9e-18 64.4 37.8 1.1e-08 35.1 13.6 2.4 2 0 0 2 2 2 2 AN1-like Zinc finger 2OG-FeII_Oxy_2 PF13532.6 CCF53875.1 - 1.1e-22 81.1 0.0 1.8e-22 80.5 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily PK PF00224.21 CCF53876.1 - 1.3e-160 534.0 6.2 1.6e-160 533.7 6.2 1.1 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.16 CCF53876.1 - 1.9e-35 121.6 0.0 4.9e-35 120.3 0.0 1.7 1 0 0 1 1 1 1 Pyruvate kinase, alpha/beta domain HpcH_HpaI PF03328.14 CCF53876.1 - 0.0003 20.0 0.2 0.0011 18.2 0.2 2.0 1 1 1 2 2 2 1 HpcH/HpaI aldolase/citrate lyase family DUF218 PF02698.17 CCF53876.1 - 0.14 12.2 0.0 0.27 11.2 0.0 1.6 1 0 0 1 1 1 0 DUF218 domain ELO PF01151.18 CCF53877.1 - 1e-59 202.1 7.5 1.3e-59 201.8 7.5 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family SNAP PF14938.6 CCF53879.1 - 1.2e-99 333.4 15.1 1.3e-99 333.2 15.1 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_12 PF13424.6 CCF53879.1 - 8.7e-06 25.9 17.3 0.03 14.6 0.4 4.2 1 1 4 5 5 5 3 Tetratricopeptide repeat TPR_MalT PF17874.1 CCF53879.1 - 0.0068 15.8 4.1 0.052 12.9 0.2 2.2 1 1 1 2 2 2 1 MalT-like TPR region Spatacsin_C PF14649.6 CCF53879.1 - 0.017 14.2 5.6 0.12 11.5 5.6 2.0 1 1 0 1 1 1 0 Spatacsin C-terminus RNA_pol_Rpb6 PF01192.22 CCF53879.1 - 0.079 12.9 0.2 1.7 8.6 0.5 2.5 2 0 0 2 2 2 0 RNA polymerase Rpb6 TPR_9 PF13371.6 CCF53879.1 - 0.093 12.9 4.9 5.8 7.1 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.6 CCF53879.1 - 0.28 11.3 9.4 26 5.1 0.0 5.0 2 2 3 5 5 5 0 Tetratricopeptide repeat TPR_1 PF00515.28 CCF53879.1 - 0.3 11.0 12.2 35 4.4 0.9 6.1 5 2 2 7 7 7 0 Tetratricopeptide repeat TPR_11 PF13414.6 CCF53879.1 - 0.82 9.4 14.6 14 5.5 0.0 5.5 3 2 3 6 6 6 0 TPR repeat TPR_6 PF13174.6 CCF53879.1 - 1.8 9.4 18.6 1.6 9.6 0.2 5.7 3 2 3 6 6 6 0 Tetratricopeptide repeat Acetyltransf_10 PF13673.7 CCF53881.1 - 5.8e-07 29.5 0.0 0.00017 21.5 0.0 2.5 3 0 0 3 3 3 2 Acetyltransferase (GNAT) domain Acetyltransf_5 PF13444.6 CCF53881.1 - 1.6e-05 25.5 0.0 0.00036 21.2 0.0 2.3 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CCF53881.1 - 0.0003 21.0 0.0 0.033 14.4 0.1 2.5 3 0 0 3 3 3 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 CCF53881.1 - 0.00085 19.7 0.3 0.0041 17.5 0.3 2.0 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain CAP_GLY PF01302.25 CCF53882.1 - 1.5e-24 85.8 2.9 2.3e-24 85.2 2.9 1.3 1 0 0 1 1 1 1 CAP-Gly domain Ubiquitin_2 PF14560.6 CCF53882.1 - 1e-14 54.7 0.0 1.5e-13 51.0 0.0 2.5 1 1 0 1 1 1 1 Ubiquitin-like domain RRM_1 PF00076.22 CCF53883.1 - 1.4e-41 140.1 0.3 1.3e-21 76.2 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RBM39linker PF15519.6 CCF53883.1 - 1.4e-12 48.5 0.7 1.4e-12 48.5 0.7 2.8 2 2 0 2 2 2 1 linker between RRM2 and RRM3 domains in RBM39 protein RRM_occluded PF16842.5 CCF53883.1 - 9.8e-05 22.1 0.0 0.00061 19.6 0.0 2.2 3 0 0 3 3 3 1 Occluded RNA-recognition motif RRM_3 PF08777.11 CCF53883.1 - 0.0008 19.4 0.0 0.0008 19.4 0.0 3.0 3 0 0 3 3 3 1 RNA binding motif Nup35_RRM_2 PF14605.6 CCF53883.1 - 0.1 12.6 0.0 7.4 6.7 0.0 2.8 3 0 0 3 3 3 0 Nup53/35/40-type RNA recognition motif CDC27 PF09507.10 CCF53883.1 - 3.5 6.9 29.5 5.3 6.3 29.5 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Ndc1_Nup PF09531.10 CCF53883.1 - 4.1 6.0 5.4 5.6 5.5 5.4 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Myc_N PF01056.18 CCF53883.1 - 7.8 6.3 14.9 16 5.2 14.9 1.5 1 0 0 1 1 1 0 Myc amino-terminal region Herpes_UL87 PF03043.14 CCF53883.1 - 8.7 4.7 6.2 13 4.1 6.2 1.2 1 0 0 1 1 1 0 Herpesvirus UL87 family ANAPC4_WD40 PF12894.7 CCF53884.1 - 1.4e-10 41.4 0.0 0.026 14.8 0.0 5.7 5 1 0 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 CCF53884.1 - 2.7e-05 24.8 9.3 2.9 8.9 0.2 5.7 6 0 0 6 6 6 3 WD domain, G-beta repeat eIF2A PF08662.11 CCF53884.1 - 3.8e-05 23.6 0.0 0.65 9.8 0.0 4.4 3 1 0 4 4 4 1 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 CCF53884.1 - 0.071 13.1 1.2 9.7 6.3 0.0 3.7 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat ELP6 PF09807.9 CCF53885.1 - 1e-10 41.5 0.0 3.1e-10 39.9 0.0 1.7 2 0 0 2 2 2 1 Elongation complex protein 6 Elong_Iki1 PF10483.9 CCF53885.1 - 0.0027 17.3 0.0 0.0057 16.2 0.0 1.7 1 1 0 1 1 1 1 Elongator subunit Iki1 Glycos_transf_1 PF00534.20 CCF53886.1 - 3e-31 108.3 0.0 7.2e-31 107.0 0.0 1.5 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 CCF53886.1 - 1.6e-24 86.8 0.0 2.7e-24 86.1 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_1_4 PF13692.6 CCF53886.1 - 2.7e-24 86.1 0.0 5.1e-24 85.2 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 CCF53886.1 - 9.7e-15 55.4 0.0 2.4e-14 54.1 0.0 1.7 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_trans_1_2 PF13524.6 CCF53886.1 - 0.087 13.2 0.0 0.22 11.9 0.0 1.6 1 0 0 1 1 1 0 Glycosyl transferases group 1 HERV-K_env_2 PF13804.6 CCF53886.1 - 0.11 12.3 0.0 0.18 11.5 0.0 1.3 1 0 0 1 1 1 0 Retro-transcribing viruses envelope glycoprotein FCH PF00611.23 CCF53887.1 - 8.8e-17 61.2 4.3 1.2e-16 60.7 0.7 2.7 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain SH3_1 PF00018.28 CCF53887.1 - 8.5e-12 44.5 0.1 1.7e-11 43.6 0.1 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 CCF53887.1 - 1.4e-10 40.8 0.0 2.6e-10 40.0 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 CCF53887.1 - 5e-09 35.7 0.0 1.2e-08 34.5 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain DUF5403 PF17395.2 CCF53887.1 - 0.023 15.0 1.3 0.055 13.8 0.2 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5403) CorA PF01544.18 CCF53888.1 - 1.9e-14 53.7 10.4 4.4e-08 32.8 2.3 4.2 4 1 0 4 4 4 3 CorA-like Mg2+ transporter protein Yip1 PF04893.17 CCF53888.1 - 0.21 11.3 0.6 0.36 10.5 0.6 1.2 1 0 0 1 1 1 0 Yip1 domain COX7C PF02935.16 CCF53889.1 - 6e-15 55.3 1.2 7e-15 55.0 1.2 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIIc Brix PF04427.18 CCF53890.1 - 4.1e-22 79.2 0.0 6.5e-22 78.6 0.0 1.3 1 0 0 1 1 1 1 Brix domain WD40 PF00400.32 CCF53891.1 - 1.8e-19 69.7 8.5 8.1e-07 29.7 0.2 6.4 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF53891.1 - 4.8e-13 49.2 0.0 0.014 15.7 0.0 5.8 4 2 2 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain RAB3GAP2_N PF14655.6 CCF53891.1 - 0.022 14.0 0.0 1.1 8.4 0.0 2.1 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus RVT_2 PF07727.14 CCF53892.1 - 2.5e-45 155.0 0.0 3.9e-36 124.9 0.0 2.1 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) Zn_clus PF00172.18 CCF53895.1 - 0.11 12.7 7.2 0.28 11.3 7.2 1.7 1 1 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF896 PF05979.12 CCF53895.1 - 0.28 11.1 0.5 0.78 9.7 0.5 1.7 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF896) RRP36 PF06102.12 CCF53897.1 - 2.3e-45 154.6 20.3 2.3e-45 154.6 20.3 3.1 2 1 0 2 2 2 1 rRNA biogenesis protein RRP36 BING4CT PF08149.11 CCF53898.1 - 1.3e-35 121.0 0.0 3.8e-33 113.1 0.0 3.4 3 0 0 3 3 3 1 BING4CT (NUC141) domain WD40 PF00400.32 CCF53898.1 - 4.9e-08 33.5 0.4 0.0091 16.8 0.0 5.0 5 0 0 5 5 5 1 WD domain, G-beta repeat Coatomer_WDAD PF04053.14 CCF53898.1 - 3.6e-05 23.0 0.0 5.9e-05 22.3 0.0 1.3 1 0 0 1 1 1 1 Coatomer WD associated region ANAPC4_WD40 PF12894.7 CCF53898.1 - 0.0024 18.1 0.0 1.9 8.9 0.0 3.4 2 1 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain GFO_IDH_MocA PF01408.22 CCF53899.1 - 4.8e-12 46.8 0.1 1.3e-11 45.3 0.1 1.9 1 1 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold CoA_binding_2 PF13380.6 CCF53899.1 - 0.12 12.8 0.0 0.29 11.6 0.0 1.5 1 0 0 1 1 1 0 CoA binding domain Syja_N PF02383.18 CCF53900.1 - 2.1e-88 296.7 0.1 2.8e-88 296.3 0.1 1.1 1 0 0 1 1 1 1 SacI homology domain JAB PF01398.21 CCF53901.1 - 2.8e-25 88.6 0.0 4.7e-25 87.9 0.0 1.4 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.6 CCF53901.1 - 3.5e-18 66.0 0.3 6.9e-18 65.1 0.3 1.5 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function UPF0172 PF03665.13 CCF53901.1 - 0.078 13.0 0.0 0.16 12.0 0.0 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0172) BppL_N PF18338.1 CCF53901.1 - 0.1 12.4 0.2 0.41 10.5 0.0 2.1 2 0 0 2 2 2 0 Lower baseplate protein N-terminal domain SH2_2 PF14633.6 CCF53902.1 - 9.7e-78 260.5 0.2 9.7e-78 260.5 0.2 2.4 2 0 0 2 2 2 1 SH2 domain HHH_7 PF14635.6 CCF53902.1 - 1.6e-23 83.1 0.0 3.7e-23 81.9 0.0 1.7 1 0 0 1 1 1 1 Helix-hairpin-helix motif YqgF PF14639.6 CCF53902.1 - 5.9e-23 81.3 0.0 1.6e-22 79.9 0.0 1.8 1 0 0 1 1 1 1 Holliday-junction resolvase-like of SPT6 HTH_44 PF14641.6 CCF53902.1 - 1e-22 80.7 0.3 2.8e-22 79.3 0.3 1.8 1 0 0 1 1 1 1 Helix-turn-helix DNA-binding domain of SPT6 SPT6_acidic PF14632.6 CCF53902.1 - 7.9e-19 68.0 27.5 7.9e-19 68.0 27.5 5.5 2 1 2 4 4 4 1 Acidic N-terminal SPT6 SH2 PF00017.24 CCF53902.1 - 0.00032 20.7 0.0 0.0014 18.7 0.0 2.2 2 0 0 2 2 2 1 SH2 domain HHH_9 PF17674.1 CCF53902.1 - 0.00057 20.7 1.2 0.00057 20.7 1.2 3.4 4 1 0 4 4 4 1 HHH domain Hid1 PF12722.7 CCF53903.1 - 0.35 8.9 5.4 0.42 8.7 5.4 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein MFS_1 PF07690.16 CCF53904.1 - 6.5e-24 84.5 14.8 2.3e-19 69.6 0.7 2.5 2 1 0 2 2 2 2 Major Facilitator Superfamily Nodulin-like PF06813.13 CCF53904.1 - 9.1e-14 51.5 7.1 1.5e-13 50.8 2.0 2.3 2 0 0 2 2 2 1 Nodulin-like Sugar_tr PF00083.24 CCF53904.1 - 0.06 12.2 12.1 0.0081 15.1 2.0 2.5 2 1 0 2 2 2 0 Sugar (and other) transporter DUF543 PF04418.12 CCF53904.1 - 0.075 13.0 0.5 1.1 9.3 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF543) Rad21_Rec8_N PF04825.13 CCF53905.1 - 2.8e-29 101.5 0.0 4.6e-29 100.8 0.0 1.3 1 0 0 1 1 1 1 N terminus of Rad21 / Rec8 like protein Rad21_Rec8 PF04824.16 CCF53905.1 - 7.1e-09 34.8 0.0 7.1e-09 34.8 0.0 1.8 2 0 0 2 2 2 1 Conserved region of Rad21 / Rec8 like protein Spc7_N PF15402.6 CCF53905.1 - 0.023 13.0 3.5 0.032 12.5 3.5 1.1 1 0 0 1 1 1 0 N-terminus of kinetochore NMS complex subunit Spc7 Peptidase_M1 PF01433.20 CCF53907.1 - 5.5e-41 140.5 0.0 7.6e-41 140.1 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M1 domain Leuk-A4-hydro_C PF09127.11 CCF53907.1 - 9.9e-37 125.5 0.0 2.3e-36 124.3 0.0 1.6 1 0 0 1 1 1 1 Leukotriene A4 hydrolase, C-terminal Peptidase_M1_N PF17900.1 CCF53907.1 - 1.5e-22 80.7 0.0 2.7e-22 79.9 0.0 1.4 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain IPPT PF01715.17 CCF53908.1 - 1.4e-53 182.0 5.3 2e-52 178.3 5.3 2.2 1 1 0 1 1 1 1 IPP transferase Autophagy_N PF03986.13 CCF53909.1 - 2.6e-40 137.6 0.0 4.5e-40 136.8 0.0 1.3 1 0 0 1 1 1 1 Autophagocytosis associated protein (Atg3), N-terminal domain Autophagy_act_C PF03987.15 CCF53909.1 - 5e-15 55.8 0.1 9.5e-15 54.9 0.1 1.5 1 0 0 1 1 1 1 Autophagocytosis associated protein, active-site domain Autophagy_C PF10381.9 CCF53909.1 - 1.7e-13 49.8 0.8 2.7e-13 49.1 0.8 1.3 1 0 0 1 1 1 1 Autophagocytosis associated protein C-terminal YLP PF02757.17 CCF53909.1 - 3.4 7.9 4.4 21 5.5 0.0 2.8 3 0 0 3 3 3 0 YLP motif RHD_DNA_bind PF00554.22 CCF53910.1 - 0.052 13.5 0.1 0.061 13.3 0.1 1.1 1 0 0 1 1 1 0 Rel homology DNA-binding domain BLUF PF04940.12 CCF53911.1 - 1.1e-30 105.6 0.0 1.7e-30 105.0 0.0 1.3 1 0 0 1 1 1 1 Sensors of blue-light using FAD NUC153 PF08159.12 CCF53912.1 - 6.9e-15 54.6 10.2 2.8e-11 43.0 0.1 3.7 3 0 0 3 3 3 3 NUC153 domain LSM PF01423.22 CCF53913.1 - 4.3e-21 74.4 0.1 5.1e-21 74.1 0.1 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 CCF53913.1 - 0.04 14.1 0.0 0.047 13.8 0.0 1.1 1 0 0 1 1 1 0 Ataxin 2 SM domain Bud13 PF09736.9 CCF53914.1 - 1.8e-46 158.2 9.7 1.8e-46 158.2 9.7 2.9 3 0 0 3 3 3 1 Pre-mRNA-splicing factor of RES complex DUF243 PF03103.17 CCF53914.1 - 0.31 11.4 3.3 0.54 10.6 2.4 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF243) SPATIAL PF15256.6 CCF53914.1 - 7.8 6.8 11.3 2.1 8.6 8.0 1.8 2 1 0 2 2 2 0 SPATIAL UPF0560 PF10577.9 CCF53914.1 - 8.9 4.7 13.4 14 4.0 13.4 1.3 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 MFS_1 PF07690.16 CCF53916.1 - 6.3e-06 25.4 32.7 0.0013 17.8 3.7 4.6 3 1 0 4 4 4 4 Major Facilitator Superfamily Zn_clus PF00172.18 CCF53918.1 - 6.6e-05 22.9 6.0 0.00013 22.0 6.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 CCF53918.1 - 0.0012 17.9 0.1 0.0023 17.0 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Gpr1_Fun34_YaaH PF01184.19 CCF53919.1 - 9.1e-88 293.3 18.3 1.1e-87 293.0 18.3 1.0 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family Methyltransf_33 PF10017.9 CCF53920.1 - 1.6e-79 267.2 0.1 1.2e-64 218.5 0.0 2.2 2 0 0 2 2 2 2 Histidine-specific methyltransferase, SAM-dependent FGE-sulfatase PF03781.16 CCF53920.1 - 6.9e-22 78.3 2.0 1.2e-12 48.0 0.1 2.3 2 0 0 2 2 2 2 Sulfatase-modifying factor enzyme 1 dCMP_cyt_deam_1 PF00383.23 CCF53920.1 - 1.3e-21 76.4 0.0 2.2e-21 75.6 0.0 1.4 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 CCF53920.1 - 4.7e-19 68.5 0.1 5e-18 65.2 0.1 2.2 1 1 0 1 1 1 1 MafB19-like deaminase Bd3614-deam PF14439.6 CCF53920.1 - 4.3e-05 23.6 0.0 0.00011 22.3 0.0 1.6 1 0 0 1 1 1 1 Bd3614-like deaminase DinB_2 PF12867.7 CCF53920.1 - 8e-05 23.1 1.2 0.0003 21.3 1.2 2.0 1 0 0 1 1 1 1 DinB superfamily Ribosomal_L31e PF01198.19 CCF53921.1 - 1e-39 134.6 0.9 1.3e-39 134.3 0.9 1.1 1 0 0 1 1 1 1 Ribosomal protein L31e JAB PF01398.21 CCF53922.1 - 2.2e-06 27.6 0.0 4.1e-06 26.8 0.0 1.4 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease DUF4203 PF13886.6 CCF53923.1 - 3.2e-46 157.5 25.3 3.2e-46 157.5 25.3 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4203) FA_desaturase PF00487.24 CCF53923.1 - 1.9 8.3 4.9 3.8 7.3 4.9 1.5 1 0 0 1 1 1 0 Fatty acid desaturase Pro_CA PF00484.19 CCF53924.1 - 2.5e-37 128.6 0.1 4.5e-37 127.8 0.1 1.4 1 0 0 1 1 1 1 Carbonic anhydrase Abhydrolase_1 PF00561.20 CCF53924.1 - 0.14 11.8 0.0 0.29 10.7 0.0 1.4 1 1 0 1 1 1 0 alpha/beta hydrolase fold p450 PF00067.22 CCF53925.1 - 4.3e-57 193.9 0.0 9.6e-57 192.7 0.0 1.4 1 1 0 1 1 1 1 Cytochrome P450 VASP_tetra PF08776.11 CCF53925.1 - 0.96 9.1 4.3 2.3 7.9 4.3 1.6 1 0 0 1 1 1 0 VASP tetramerisation domain Apt1 PF10351.9 CCF53926.1 - 1.3 7.8 5.5 1.7 7.4 5.5 1.3 1 0 0 1 1 1 0 Golgi-body localisation protein domain E1-E2_ATPase PF00122.20 CCF53927.1 - 9.1e-40 136.1 14.3 2.6e-29 102.0 0.0 3.7 3 1 0 4 4 4 2 E1-E2 ATPase Cation_ATPase_C PF00689.21 CCF53927.1 - 7.9e-32 110.4 3.5 7.9e-32 110.4 3.5 2.5 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 CCF53927.1 - 7.3e-20 72.2 0.4 2.8e-19 70.2 0.4 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 CCF53927.1 - 1.2e-15 56.9 0.1 1.2e-15 56.9 0.1 3.0 4 0 0 4 4 4 1 Cation transporter/ATPase, N-terminus Cation_ATPase PF13246.6 CCF53927.1 - 1.2e-15 57.3 0.0 2.6e-15 56.3 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 CCF53927.1 - 0.019 14.7 3.2 0.019 14.7 0.0 2.2 3 0 0 3 3 3 0 haloacid dehalogenase-like hydrolase MBF1 PF08523.10 CCF53927.1 - 0.16 12.4 0.9 1.6 9.2 0.4 2.4 2 0 0 2 2 2 0 Multiprotein bridging factor 1 HSP9_HSP12 PF04119.12 CCF53928.1 - 3.1e-20 72.3 9.2 3.1e-20 72.3 9.2 2.0 1 1 0 2 2 2 1 Heat shock protein 9/12 MT0933_antitox PF14013.6 CCF53928.1 - 0.046 14.0 6.5 18 5.8 6.5 2.5 1 1 0 1 1 1 0 MT0933-like antitoxin protein Sugar_tr PF00083.24 CCF53929.1 - 1.6e-20 73.4 19.1 1.8e-20 73.2 4.9 2.2 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 CCF53929.1 - 2.5e-19 69.4 55.5 3.1e-15 56.0 26.7 3.1 1 1 0 2 2 2 2 Major Facilitator Superfamily UPF0126 PF03458.13 CCF53929.1 - 0.011 15.7 2.2 0.011 15.7 2.2 2.2 2 0 0 2 2 2 0 UPF0126 domain RVT_2 PF07727.14 CCF53930.1 - 0.0024 17.5 0.0 0.0031 17.2 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Mito_carr PF00153.27 CCF53931.1 - 1.1e-61 204.7 4.9 1.9e-21 75.8 0.1 4.3 4 0 0 4 4 4 4 Mitochondrial carrier protein Serine_protease PF18405.1 CCF53931.1 - 0.06 12.5 2.2 0.36 9.9 0.0 2.7 3 0 0 3 3 3 0 Gammaproteobacterial serine protease MSC PF09402.10 CCF53932.1 - 4.5e-93 312.4 0.1 6.6e-93 311.8 0.1 1.3 1 0 0 1 1 1 1 Man1-Src1p-C-terminal domain HeH PF12949.7 CCF53932.1 - 1e-14 53.9 0.0 1e-14 53.9 0.0 2.0 2 0 0 2 2 2 1 HeH/LEM domain Orthopox_A5L PF06193.11 CCF53934.1 - 0.039 13.4 2.5 0.055 12.9 2.4 1.5 1 1 0 1 1 1 0 Orthopoxvirus A5L protein-like FAD_binding_3 PF01494.19 CCF53935.1 - 1.2e-28 100.4 0.0 3e-28 99.1 0.0 1.6 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.24 CCF53935.1 - 1.8e-09 37.6 0.4 0.00014 21.5 0.0 2.2 1 1 1 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CCF53935.1 - 3.1e-09 36.5 0.1 0.0022 17.3 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CCF53935.1 - 3.6e-07 30.7 0.3 0.00016 22.2 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CCF53935.1 - 0.00098 19.3 0.0 0.0023 18.1 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain AlaDh_PNT_C PF01262.21 CCF53935.1 - 0.048 12.9 0.0 0.083 12.2 0.0 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain FAD_binding_2 PF00890.24 CCF53935.1 - 0.07 12.2 0.0 0.11 11.6 0.0 1.3 1 0 0 1 1 1 0 FAD binding domain Trp_halogenase PF04820.14 CCF53935.1 - 0.12 11.2 0.1 2.6 6.8 0.1 2.6 3 0 0 3 3 3 0 Tryptophan halogenase SE PF08491.10 CCF53935.1 - 0.12 11.4 0.0 1.3 8.0 0.0 2.0 2 0 0 2 2 2 0 Squalene epoxidase CoA_transf_3 PF02515.17 CCF53935.1 - 0.17 11.0 0.0 0.27 10.3 0.0 1.3 1 0 0 1 1 1 0 CoA-transferase family III Spc24 PF08286.11 CCF53938.1 - 2.7e-18 66.1 3.5 2.7e-18 66.1 3.5 2.0 2 1 0 2 2 2 1 Spc24 subunit of Ndc80 Spc7 PF08317.11 CCF53938.1 - 0.019 13.9 9.7 0.025 13.5 9.7 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein MAD PF05557.13 CCF53938.1 - 0.043 12.2 14.9 0.055 11.8 14.9 1.1 1 0 0 1 1 1 0 Mitotic checkpoint protein FapA PF03961.13 CCF53938.1 - 0.055 12.1 1.9 0.07 11.7 1.9 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A Mu-like_Pro PF10123.9 CCF53938.1 - 0.15 11.6 6.4 0.21 11.1 6.4 1.2 1 0 0 1 1 1 0 Mu-like prophage I protein Nsp1_C PF05064.13 CCF53938.1 - 0.18 11.6 11.4 1.2 9.0 8.0 2.5 2 1 1 3 3 3 0 Nsp1-like C-terminal region Cnn_1N PF07989.11 CCF53938.1 - 0.4 10.9 11.9 0.19 11.9 8.2 2.3 1 1 1 2 2 2 0 Centrosomin N-terminal motif 1 TMF_DNA_bd PF12329.8 CCF53938.1 - 0.43 10.6 14.2 0.051 13.6 7.4 2.3 1 1 0 2 2 2 0 TATA element modulatory factor 1 DNA binding BBP1_C PF15272.6 CCF53938.1 - 0.52 10.1 9.8 0.74 9.6 9.8 1.3 1 1 0 1 1 1 0 Spindle pole body component BBP1, C-terminal TMPIT PF07851.13 CCF53938.1 - 0.59 9.3 3.0 0.8 8.9 3.0 1.3 1 0 0 1 1 1 0 TMPIT-like protein Sec2p PF06428.11 CCF53938.1 - 0.68 9.9 12.4 2.6 8.1 11.8 2.3 1 1 0 1 1 1 0 GDP/GTP exchange factor Sec2p APG6_N PF17675.1 CCF53938.1 - 0.69 10.4 15.3 0.93 10.0 14.4 1.7 1 1 0 1 1 1 0 Apg6 coiled-coil region SlyX PF04102.12 CCF53938.1 - 3.7 8.2 11.2 1.1 9.9 6.5 2.4 1 1 1 2 2 2 0 SlyX Spore_III_AB PF09548.10 CCF53938.1 - 3.9 7.6 9.8 11 6.1 3.6 2.2 1 1 1 2 2 2 0 Stage III sporulation protein AB (spore_III_AB) YabA PF06156.13 CCF53938.1 - 9 7.0 8.3 3.7 8.2 3.9 2.2 1 1 1 2 2 2 0 Initiation control protein YabA DivIC PF04977.15 CCF53938.1 - 9.6 6.1 11.4 21 5.0 6.3 2.4 1 1 1 2 2 2 0 Septum formation initiator Vac_ImportDeg PF09783.9 CCF53939.1 - 2.4e-54 183.5 0.0 5.6e-49 166.1 0.0 2.2 2 0 0 2 2 2 2 Vacuolar import and degradation protein Gpi1 PF05024.15 CCF53940.1 - 3.4e-55 187.0 12.4 5.2e-55 186.4 12.4 1.3 1 0 0 1 1 1 1 N-acetylglucosaminyl transferase component (Gpi1) Aldedh PF00171.22 CCF53941.1 - 1.9e-127 425.6 0.1 2.3e-127 425.3 0.1 1.1 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.14 CCF53941.1 - 0.0058 15.7 0.0 0.042 12.9 0.0 2.0 2 0 0 2 2 2 1 Acyl-CoA reductase (LuxC) Flagellin_IN PF07196.13 CCF53941.1 - 0.11 12.7 0.2 0.44 10.8 0.2 2.1 1 0 0 1 1 1 0 Flagellin hook IN motif AA_kinase PF00696.28 CCF53942.1 - 6.5e-42 143.8 0.4 1.1e-41 143.0 0.4 1.4 1 0 0 1 1 1 1 Amino acid kinase family PUA PF01472.20 CCF53942.1 - 2.8e-10 40.0 0.4 0.00011 22.1 0.0 2.9 3 0 0 3 3 3 2 PUA domain AAA PF00004.29 CCF53943.1 - 2e-17 63.8 0.1 1.1e-16 61.5 0.0 2.2 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Rep_fac_C PF08542.11 CCF53943.1 - 1.2e-13 51.3 0.2 3.2e-13 49.9 0.2 1.7 1 0 0 1 1 1 1 Replication factor C C-terminal domain DNA_pol3_delta2 PF13177.6 CCF53943.1 - 1.3e-13 51.0 0.0 2e-11 43.9 0.0 2.4 1 1 0 1 1 1 1 DNA polymerase III, delta subunit Rad17 PF03215.15 CCF53943.1 - 4e-08 33.4 0.0 2.1e-07 31.1 0.0 2.0 1 1 0 1 1 1 1 Rad17 P-loop domain AAA_22 PF13401.6 CCF53943.1 - 4.4e-06 27.0 2.0 0.02 15.1 0.0 3.2 2 1 0 3 3 3 1 AAA domain AAA_16 PF13191.6 CCF53943.1 - 1.6e-05 25.4 0.0 0.00095 19.6 0.0 2.6 1 1 1 2 2 2 1 AAA ATPase domain AAA_11 PF13086.6 CCF53943.1 - 3.8e-05 23.6 0.3 0.00015 21.6 0.0 2.1 1 1 1 2 2 2 1 AAA domain RuvB_N PF05496.12 CCF53943.1 - 0.00018 21.3 0.1 0.00057 19.7 0.0 1.8 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_assoc_2 PF16193.5 CCF53943.1 - 0.00022 21.5 0.0 0.00074 19.8 0.0 1.9 1 0 0 1 1 1 1 AAA C-terminal domain AAA_14 PF13173.6 CCF53943.1 - 0.00071 19.6 0.0 0.0016 18.5 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.14 CCF53943.1 - 0.00072 19.6 0.0 0.0017 18.3 0.0 1.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 CCF53943.1 - 0.00086 18.7 0.1 0.031 13.7 0.0 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_24 PF13479.6 CCF53943.1 - 0.00087 19.1 0.0 0.0018 18.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 CCF53943.1 - 0.0014 19.0 0.4 0.017 15.4 0.1 2.6 2 2 0 2 2 2 1 AAA domain AAA_30 PF13604.6 CCF53943.1 - 0.0016 18.2 0.0 0.0066 16.2 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_7 PF12775.7 CCF53943.1 - 0.0021 17.6 0.0 0.0038 16.8 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region ResIII PF04851.15 CCF53943.1 - 0.0023 18.0 0.0 0.033 14.2 0.0 2.3 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.29 CCF53943.1 - 0.0044 16.8 0.4 0.067 12.9 0.0 2.5 2 1 1 3 3 3 1 DEAD/DEAH box helicase AAA_28 PF13521.6 CCF53943.1 - 0.0081 16.4 0.0 0.029 14.6 0.0 2.0 2 1 0 2 2 1 1 AAA domain DUF815 PF05673.13 CCF53943.1 - 0.019 14.1 0.0 0.029 13.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_3 PF07726.11 CCF53943.1 - 0.02 14.8 0.1 0.092 12.6 0.0 2.2 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) FtsK_SpoIIIE PF01580.18 CCF53943.1 - 0.025 14.0 0.1 4.7 6.5 0.0 2.5 3 0 0 3 3 3 0 FtsK/SpoIIIE family MCM PF00493.23 CCF53943.1 - 0.026 13.6 0.0 0.1 11.7 0.0 1.9 1 1 0 1 1 1 0 MCM P-loop domain AAA_18 PF13238.6 CCF53943.1 - 0.049 14.2 0.0 0.12 13.0 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_2 PF07724.14 CCF53943.1 - 0.073 13.2 0.0 0.17 12.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) Parvo_NS1 PF01057.17 CCF53943.1 - 0.085 11.9 0.0 0.16 11.1 0.0 1.4 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 DUF2075 PF09848.9 CCF53943.1 - 0.09 12.0 0.0 0.39 9.9 0.0 1.9 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_33 PF13671.6 CCF53943.1 - 0.12 12.5 0.0 0.34 11.0 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 CCF53943.1 - 0.15 12.6 0.0 0.26 11.8 0.0 1.6 1 1 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 CCF53943.1 - 0.16 12.4 0.0 0.46 10.9 0.0 1.8 1 0 0 1 1 1 0 RNA helicase CAF1A PF12253.8 CCF53944.1 - 4.7e-22 77.9 3.4 4.7e-22 77.9 3.4 3.3 2 1 1 3 3 3 1 Chromatin assembly factor 1 subunit A Mrr_N PF14338.6 CCF53944.1 - 0.45 10.7 4.2 0.65 10.2 0.1 3.0 2 0 0 2 2 2 0 Mrr N-terminal domain Efg1 PF10153.9 CCF53944.1 - 0.88 10.0 20.6 17 5.8 16.8 3.1 2 0 0 2 2 2 0 rRNA-processing protein Efg1 Borrelia_P83 PF05262.11 CCF53944.1 - 2.1 6.8 17.7 5.5 5.4 17.7 1.7 1 0 0 1 1 1 0 Borrelia P83/100 protein WD40 PF00400.32 CCF53945.1 - 3.4e-38 128.9 22.9 2.7e-07 31.2 1.5 7.7 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF53945.1 - 5.5e-18 65.1 0.4 0.0028 17.9 0.0 6.2 2 1 5 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CCF53945.1 - 2.2e-07 30.2 0.8 0.00042 19.4 0.0 2.7 2 1 1 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 CCF53945.1 - 3.5e-06 27.0 0.1 0.011 15.6 0.1 3.1 2 1 3 5 5 5 4 Eukaryotic translation initiation factor eIF2A MgtE PF01769.16 CCF53946.1 - 1.5e-42 144.9 32.0 5.5e-26 91.4 9.0 4.2 2 1 1 3 3 3 2 Divalent cation transporter TMA7 PF09072.10 CCF53947.1 - 2.4e-17 63.5 16.8 2.9e-17 63.3 16.8 1.1 1 0 0 1 1 1 1 Translation machinery associated TMA7 Tetraspanin PF00335.20 CCF53948.1 - 2.8e-05 24.0 6.4 2.9e-05 23.9 4.0 1.9 2 0 0 2 2 2 1 Tetraspanin family MscL PF01741.18 CCF53948.1 - 0.014 15.7 0.5 0.025 14.9 0.5 1.4 1 0 0 1 1 1 0 Large-conductance mechanosensitive channel, MscL MFS_1 PF07690.16 CCF53949.1 - 7.7e-28 97.4 54.3 1e-14 54.3 21.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF1325 PF07039.11 CCF53951.1 - 4.1e-29 101.3 0.0 5.9e-29 100.8 0.0 1.2 1 0 0 1 1 1 1 SGF29 tudor-like domain LBR_tudor PF09465.10 CCF53951.1 - 0.065 13.0 0.5 7.4 6.5 0.0 2.5 2 0 0 2 2 2 0 Lamin-B receptor of TUDOR domain E1-E2_ATPase PF00122.20 CCF53952.1 - 6.3e-46 156.2 2.8 1.5e-45 154.9 2.8 1.7 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.26 CCF53952.1 - 3e-33 115.9 2.6 3.7e-33 115.6 0.9 2.1 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HMA PF00403.26 CCF53952.1 - 1.1e-30 105.8 0.3 1.5e-14 54.2 0.1 2.9 3 0 0 3 3 3 2 Heavy-metal-associated domain Hydrolase_3 PF08282.12 CCF53952.1 - 8.4e-05 22.4 0.8 0.0094 15.7 0.4 2.3 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD PF12710.7 CCF53952.1 - 0.0013 19.2 0.0 0.0031 17.9 0.0 1.7 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 CCF53952.1 - 0.016 15.3 0.0 0.23 11.6 0.0 2.9 3 0 0 3 3 3 0 Haloacid dehalogenase-like hydrolase Fer2_BFD PF04324.15 CCF53952.1 - 0.12 12.8 0.4 3 8.3 0.1 2.9 2 0 0 2 2 2 0 BFD-like [2Fe-2S] binding domain FMO-like PF00743.19 CCF53955.1 - 4.5e-27 94.7 0.0 1.2e-16 60.3 0.0 3.1 3 0 0 3 3 3 3 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 CCF53955.1 - 5.4e-12 45.6 0.0 2.8e-07 30.1 0.0 3.4 4 0 0 4 4 4 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 CCF53955.1 - 2.4e-10 40.1 0.0 0.00073 18.9 0.0 3.3 2 1 2 4 4 4 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CCF53955.1 - 5.5e-08 33.0 0.0 3e-05 24.1 0.0 2.4 2 0 0 2 2 2 2 FAD-NAD(P)-binding K_oxygenase PF13434.6 CCF53955.1 - 2.6e-06 26.8 0.0 0.0017 17.6 0.0 3.0 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 CCF53955.1 - 3.8e-06 27.0 0.1 2.4e-05 24.5 0.0 2.4 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CCF53955.1 - 0.00019 21.1 0.0 0.044 13.4 0.0 2.6 2 0 0 2 2 2 2 FAD dependent oxidoreductase HI0933_like PF03486.14 CCF53955.1 - 0.024 13.3 0.0 0.21 10.2 0.0 2.0 2 0 0 2 2 2 0 HI0933-like protein FAD_binding_3 PF01494.19 CCF53955.1 - 0.035 13.3 0.0 0.11 11.7 0.0 1.8 2 0 0 2 2 2 0 FAD binding domain Formyl_trans_N PF00551.19 CCF53956.1 - 2e-37 128.7 0.0 2.8e-37 128.2 0.0 1.2 1 0 0 1 1 1 1 Formyl transferase ACT PF01842.25 CCF53956.1 - 1e-06 28.4 0.0 2.8e-06 27.0 0.0 1.7 1 0 0 1 1 1 1 ACT domain ACT_6 PF13740.6 CCF53956.1 - 2e-05 24.5 0.0 7.8e-05 22.6 0.0 2.0 2 0 0 2 2 2 1 ACT domain Gtr1_RagA PF04670.12 CCF53957.1 - 1.2e-86 289.8 0.0 1.9e-86 289.2 0.0 1.4 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 CCF53957.1 - 1.1e-05 25.4 0.0 2.2e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase Ras PF00071.22 CCF53957.1 - 1.6e-05 24.6 0.0 2.9e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CCF53957.1 - 1.8e-05 24.9 0.0 4e-05 23.8 0.0 1.7 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CCF53957.1 - 0.00046 19.7 0.0 0.00079 18.9 0.0 1.4 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 CCF53957.1 - 0.017 14.3 0.4 3.6 6.6 0.0 2.3 1 1 1 2 2 2 0 G-protein alpha subunit AAA_16 PF13191.6 CCF53957.1 - 0.033 14.6 0.2 0.089 13.2 0.0 1.9 2 1 0 2 2 2 0 AAA ATPase domain RsgA_GTPase PF03193.16 CCF53957.1 - 0.035 14.0 0.1 0.89 9.4 0.0 2.3 2 0 0 2 2 2 0 RsgA GTPase PRK PF00485.18 CCF53957.1 - 0.045 13.5 0.0 0.15 11.8 0.0 1.9 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family PduV-EutP PF10662.9 CCF53957.1 - 0.049 13.4 0.2 0.12 12.1 0.2 1.7 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation ABC_tran PF00005.27 CCF53957.1 - 0.057 13.9 0.0 0.13 12.7 0.0 1.6 1 0 0 1 1 1 0 ABC transporter AAA_7 PF12775.7 CCF53957.1 - 0.073 12.6 0.0 0.56 9.7 0.0 2.1 2 0 0 2 2 2 0 P-loop containing dynein motor region Smg4_UPF3 PF03467.15 CCF53958.1 - 2.5e-60 203.5 0.0 2.5e-60 203.5 0.0 3.4 4 0 0 4 4 4 1 Smg-4/UPF3 family RRM_2 PF04059.12 CCF53958.1 - 0.13 12.5 0.0 0.29 11.4 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif 2 SYF2 PF08231.12 CCF53959.1 - 4.3e-45 154.0 16.8 9.5e-45 152.8 16.8 1.6 1 0 0 1 1 1 1 SYF2 splicing factor DUF1499 PF07386.11 CCF53959.1 - 5.3 7.6 11.2 38 4.9 11.0 2.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1499) Cellulase PF00150.18 CCF53960.1 - 4.4e-18 65.7 1.3 4.4e-18 65.7 1.3 1.6 2 0 0 2 2 2 1 Cellulase (glycosyl hydrolase family 5) UPF1_Zn_bind PF09416.10 CCF53961.1 - 3.9e-71 238.0 5.1 3.9e-71 238.0 5.1 1.7 2 0 0 2 2 2 1 RNA helicase (UPF2 interacting domain) AAA_12 PF13087.6 CCF53961.1 - 2.8e-59 200.1 0.0 5.6e-59 199.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 CCF53961.1 - 4.5e-49 167.6 3.6 6.2e-28 98.3 0.5 2.4 1 1 1 2 2 2 2 AAA domain DUF5599 PF18141.1 CCF53961.1 - 6.9e-32 109.5 0.0 1.3e-31 108.6 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF5599) AAA_30 PF13604.6 CCF53961.1 - 9.5e-14 51.6 0.0 6.2e-13 48.9 0.0 2.3 2 1 0 2 2 2 1 AAA domain AAA_19 PF13245.6 CCF53961.1 - 5.2e-10 39.8 0.0 2.1e-09 37.9 0.0 2.0 1 1 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 CCF53961.1 - 3.3e-05 23.7 0.3 0.35 10.6 0.0 3.2 3 1 0 3 3 3 2 Viral (Superfamily 1) RNA helicase ResIII PF04851.15 CCF53961.1 - 6.5e-05 23.0 0.0 0.00012 22.2 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DUF2075 PF09848.9 CCF53961.1 - 9.5e-05 21.8 1.1 0.008 15.5 0.1 2.9 2 1 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) Helicase_RecD PF05127.14 CCF53961.1 - 0.00081 19.3 0.0 0.0019 18.1 0.0 1.7 1 1 0 1 1 1 1 Helicase AAA_22 PF13401.6 CCF53961.1 - 0.0013 19.1 0.0 0.0033 17.7 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_10 PF12846.7 CCF53961.1 - 0.0016 17.4 0.0 0.0024 16.9 0.0 1.2 1 0 0 1 1 1 1 AAA-like domain PIF1 PF05970.14 CCF53961.1 - 0.017 14.3 0.0 1.4 8.0 0.0 2.2 2 0 0 2 2 2 0 PIF1-like helicase Ribosomal_S13_N PF08069.12 CCF53961.1 - 0.026 14.5 0.0 0.068 13.2 0.0 1.7 1 0 0 1 1 1 0 Ribosomal S13/S15 N-terminal domain PhoH PF02562.16 CCF53961.1 - 0.084 12.3 0.0 0.28 10.6 0.0 1.8 2 0 0 2 2 2 0 PhoH-like protein T2SSE PF00437.20 CCF53961.1 - 0.093 11.8 0.0 0.16 11.0 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein DEAD PF00270.29 CCF53961.1 - 0.13 12.0 0.1 0.24 11.2 0.1 1.5 1 0 0 1 1 1 0 DEAD/DEAH box helicase ATPase PF06745.13 CCF53961.1 - 0.18 11.1 0.0 0.49 9.7 0.0 1.6 2 0 0 2 2 2 0 KaiC SRP54 PF00448.22 CCF53961.1 - 0.21 11.2 0.0 0.39 10.3 0.0 1.4 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain Phospho_p8 PF10195.9 CCF53961.1 - 0.75 10.3 3.6 1.9 9.0 3.6 1.7 1 0 0 1 1 1 0 DNA-binding nuclear phosphoprotein p8 ISG65-75 PF11727.8 CCF53962.1 - 0.31 10.2 6.7 1.2 8.3 6.7 2.0 1 0 0 1 1 1 0 Invariant surface glycoprotein Tup_N PF08581.10 CCF53962.1 - 0.67 10.3 9.2 3.8 7.9 5.3 2.6 2 0 0 2 2 2 0 Tup N-terminal DUF1664 PF07889.12 CCF53962.1 - 1.6 8.8 8.9 1.7 8.7 3.2 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) HMMR_N PF15905.5 CCF53962.1 - 2.3 7.6 27.0 0.93 8.9 10.2 3.5 2 1 0 2 2 2 0 Hyaluronan mediated motility receptor N-terminal ROS_MUCR PF05443.11 CCF53962.1 - 8.9 6.4 7.6 1.8 8.7 0.3 3.3 3 0 0 3 3 3 0 ROS/MUCR transcriptional regulator protein Response_reg PF00072.24 CCF53963.1 - 5.9e-21 74.7 0.1 2.1e-15 56.8 0.1 2.5 2 0 0 2 2 2 2 Response regulator receiver domain Oxidored_nitro PF00148.19 CCF53963.1 - 0.038 12.7 0.0 0.062 12.0 0.0 1.2 1 0 0 1 1 1 0 Nitrogenase component 1 type Oxidoreductase Ribosomal_S6 PF01250.17 CCF53964.1 - 5e-24 84.4 0.0 6e-24 84.1 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S6 WD40 PF00400.32 CCF53965.1 - 1.9e-05 25.3 6.7 0.92 10.5 0.0 7.0 8 0 0 8 8 8 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF53965.1 - 2.2e-05 24.6 0.0 0.26 11.6 0.0 5.4 6 0 0 6 6 6 1 Anaphase-promoting complex subunit 4 WD40 domain PQQ_3 PF13570.6 CCF53965.1 - 0.0013 19.2 0.2 0.031 14.8 0.1 3.1 2 0 0 2 2 2 1 PQQ-like domain DEAD PF00270.29 CCF53966.1 - 1.3e-27 96.7 0.4 5e-27 94.8 0.4 1.9 1 1 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CCF53966.1 - 2.8e-26 92.0 0.1 4.1e-25 88.3 0.0 2.8 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 CCF53966.1 - 8.8e-05 22.6 0.5 0.00031 20.8 0.0 2.1 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 CCF53966.1 - 0.011 16.0 0.0 0.093 13.0 0.0 2.4 2 0 0 2 2 2 0 AAA domain EF_assoc_1 PF08355.12 CCF53967.1 - 0.072 12.7 0.0 0.12 11.9 0.0 1.4 1 0 0 1 1 1 0 EF hand associated EF_assoc_2 PF08356.12 CCF53967.1 - 0.096 12.7 0.0 0.16 11.9 0.0 1.3 1 0 0 1 1 1 0 EF hand associated Mito_carr PF00153.27 CCF53969.1 - 3.8e-54 180.6 2.6 2.7e-18 65.7 0.2 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein Ribosomal_60s PF00428.19 CCF53970.1 - 2.8e-27 95.1 12.1 3.4e-27 94.9 12.1 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein TctA PF01970.16 CCF53970.1 - 0.058 12.1 0.1 0.061 12.0 0.1 1.1 1 0 0 1 1 1 0 Tripartite tricarboxylate transporter TctA family DUF3824 PF12868.7 CCF53970.1 - 0.19 12.4 5.5 0.28 11.9 5.5 1.2 1 0 0 1 1 1 0 Domain of unknwon function (DUF3824) Cytomega_UL84 PF06284.11 CCF53970.1 - 0.23 9.9 0.7 0.29 9.5 0.7 1.1 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein F-box-like PF12937.7 CCF53971.1 - 4.7e-05 23.2 0.3 0.00019 21.2 0.3 2.1 1 1 0 1 1 1 1 F-box-like F-box PF00646.33 CCF53971.1 - 0.057 13.3 0.2 0.53 10.2 0.1 2.2 2 0 0 2 2 2 0 F-box domain CAP_N PF01213.19 CCF53972.1 - 2.3e-116 388.7 4.9 2.3e-116 388.7 4.9 1.7 1 1 0 1 1 1 1 Adenylate cyclase associated (CAP) N terminal CAP_C PF08603.11 CCF53972.1 - 2.3e-61 206.0 0.8 3e-61 205.6 0.8 1.1 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal TBCC PF07986.12 CCF53972.1 - 0.0031 17.2 3.3 0.0054 16.5 3.3 1.3 1 0 0 1 1 1 1 Tubulin binding cofactor C Dscam_C PF12355.8 CCF53972.1 - 3.1 8.8 9.3 3 8.8 0.9 2.4 2 0 0 2 2 2 0 Down syndrome cell adhesion molecule C terminal Ndc80_HEC PF03801.13 CCF53973.1 - 1.3e-30 106.1 0.5 5.7e-29 100.7 0.0 2.6 3 0 0 3 3 3 1 HEC/Ndc80p family DUF5595 PF18077.1 CCF53973.1 - 3e-21 75.3 3.2 3e-21 75.3 3.2 4.3 3 1 1 4 4 4 1 Domain of unknown function (DUF5595) OstA PF03968.14 CCF53973.1 - 0.035 14.3 0.1 0.1 12.8 0.1 1.7 1 0 0 1 1 1 0 OstA-like protein Exonuc_VII_L PF02601.15 CCF53973.1 - 1.1 8.7 21.8 0.63 9.5 8.0 2.3 2 0 0 2 2 2 0 Exonuclease VII, large subunit Spc7 PF08317.11 CCF53973.1 - 2.6 6.8 34.9 1.5 7.7 10.5 2.5 2 0 0 2 2 2 0 Spc7 kinetochore protein zf-CCCH_7 PF18586.1 CCF53973.1 - 3.1 8.2 4.5 32 5.0 0.3 2.4 2 0 0 2 2 2 0 Chromatin remodeling factor Mit1 C-terminal Zn finger 1 Cellulase PF00150.18 CCF53974.1 - 7.4e-11 42.0 0.0 4.6e-08 32.8 0.0 2.9 3 0 0 3 3 3 2 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_5_C PF18564.1 CCF53974.1 - 2.3e-10 40.9 0.1 3.2e-09 37.2 0.0 2.6 2 0 0 2 2 2 1 Glycoside hydrolase family 5 C-terminal domain Utp14 PF04615.13 CCF53975.1 - 0.00048 18.9 10.5 0.00058 18.6 10.5 1.0 1 0 0 1 1 1 1 Utp14 protein DPBB_1 PF03330.18 CCF53975.1 - 0.00049 20.3 0.5 0.0012 19.1 0.0 2.0 2 0 0 2 2 2 1 Lytic transglycolase Nop14 PF04147.12 CCF53975.1 - 0.0037 15.6 2.8 0.0042 15.4 2.8 1.2 1 0 0 1 1 1 1 Nop14-like family TFIIF_alpha PF05793.12 CCF53975.1 - 0.0043 15.7 22.8 0.0053 15.4 22.8 1.1 1 0 0 1 1 1 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) YL1 PF05764.13 CCF53975.1 - 0.026 14.7 15.2 0.036 14.2 15.2 1.1 1 0 0 1 1 1 0 YL1 nuclear protein SAPS PF04499.15 CCF53975.1 - 0.24 10.1 1.9 0.27 10.0 1.9 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Cwf_Cwc_15 PF04889.12 CCF53975.1 - 0.33 10.6 18.5 0.29 10.8 17.4 1.4 1 1 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein SDA1 PF05285.12 CCF53975.1 - 0.38 10.1 14.8 0.57 9.5 14.8 1.2 1 0 0 1 1 1 0 SDA1 DUF2457 PF10446.9 CCF53975.1 - 0.58 9.2 15.6 0.9 8.6 15.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) PBP1_TM PF14812.6 CCF53975.1 - 1.1 9.7 6.7 2 8.8 6.7 1.5 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal CDC45 PF02724.14 CCF53975.1 - 1.3 7.3 11.3 1.6 6.9 11.3 1.2 1 0 0 1 1 1 0 CDC45-like protein CENP-B_dimeris PF09026.10 CCF53975.1 - 1.3 9.5 9.9 2.5 8.5 9.9 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain NST1 PF13945.6 CCF53975.1 - 2.7 8.1 15.8 4.4 7.4 15.8 1.4 1 0 0 1 1 1 0 Salt tolerance down-regulator rRNA_processing PF08524.11 CCF53975.1 - 7.8 6.5 11.6 11 6.1 11.1 1.5 1 1 0 1 1 1 0 rRNA processing FAM220 PF15487.6 CCF53975.1 - 8.5 5.9 9.2 13 5.3 9.2 1.2 1 0 0 1 1 1 0 FAM220 family Hydrolase_4 PF12146.8 CCF53976.1 - 1.2e-05 24.7 0.0 0.0087 15.3 0.0 2.3 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 CCF53976.1 - 0.00072 19.3 0.2 0.0022 17.7 0.1 1.8 2 0 0 2 2 2 1 alpha/beta hydrolase fold GAGE PF05831.11 CCF53978.1 - 0.022 15.3 0.9 0.026 15.0 0.9 1.1 1 0 0 1 1 1 0 GAGE protein Tmemb_55A PF09788.9 CCF53979.1 - 1.4 7.9 4.8 2.6 7.1 4.8 1.4 1 0 0 1 1 1 0 Transmembrane protein 55A RRM_1 PF00076.22 CCF53980.1 - 1.8e-09 37.3 0.0 3.6e-08 33.1 0.0 2.2 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 CCF53980.1 - 0.001 18.6 0.0 0.0018 17.8 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) E1-N PF14463.6 CCF53980.1 - 0.013 15.3 0.2 0.027 14.3 0.2 1.5 1 0 0 1 1 1 0 E1 N-terminal domain GAS2 PF02187.17 CCF53981.1 - 2.5e-11 43.5 0.0 5.1e-11 42.5 0.0 1.6 1 0 0 1 1 1 1 Growth-Arrest-Specific Protein 2 Domain TRM13 PF05206.14 CCF53981.1 - 0.026 14.1 0.5 0.05 13.1 0.5 1.4 1 0 0 1 1 1 0 Methyltransferase TRM13 Tmemb_cc2 PF10267.9 CCF53981.1 - 0.048 12.8 2.0 0.14 11.3 2.0 1.7 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein adh_short PF00106.25 CCF53982.1 - 2.5e-44 151.1 0.0 3e-44 150.8 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF53982.1 - 1.4e-33 116.4 0.0 1.8e-33 116.1 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF53982.1 - 1.7e-09 37.9 0.0 4.1e-09 36.6 0.0 1.7 1 1 0 1 1 1 1 KR domain DUF1776 PF08643.10 CCF53982.1 - 2.1e-07 30.6 0.0 3.1e-07 30.0 0.0 1.2 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) Epimerase PF01370.21 CCF53982.1 - 0.0033 16.9 0.2 0.03 13.8 0.2 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Eno-Rase_NADH_b PF12242.8 CCF53982.1 - 0.02 14.6 0.0 0.036 13.8 0.0 1.4 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase THF_DHG_CYH_C PF02882.19 CCF53982.1 - 0.03 13.6 0.0 0.054 12.8 0.0 1.4 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Fasciclin PF02469.22 CCF53983.1 - 9e-54 181.1 0.0 1.9e-13 50.8 0.0 6.9 7 0 0 7 7 7 6 Fasciclin domain DUF4381 PF14316.6 CCF53983.1 - 0.35 11.1 2.6 0.71 10.1 2.6 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) RINGv PF12906.7 CCF53984.1 - 5.5e-13 48.8 4.8 9.5e-13 48.1 4.8 1.4 1 0 0 1 1 1 1 RING-variant domain Glypican PF01153.19 CCF53984.1 - 0.16 10.7 1.3 0.27 10.0 1.3 1.2 1 0 0 1 1 1 0 Glypican zf-RING_2 PF13639.6 CCF53984.1 - 0.21 12.0 2.3 0.38 11.1 2.3 1.5 1 0 0 1 1 1 0 Ring finger domain DUF983 PF06170.12 CCF53984.1 - 0.59 10.6 2.4 2.6 8.5 0.2 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF983) HemY_N PF07219.13 CCF53984.1 - 1.3 9.3 3.8 30 4.8 0.3 2.9 3 0 0 3 3 3 0 HemY protein N-terminus Radical_SAM_C PF16199.5 CCF53985.1 - 1.4e-31 108.4 0.1 3.4e-31 107.1 0.0 1.8 2 0 0 2 2 2 1 Radical_SAM C-terminal domain Radical_SAM PF04055.21 CCF53985.1 - 9e-18 65.2 0.1 2.5e-17 63.8 0.1 1.7 1 0 0 1 1 1 1 Radical SAM superfamily Acetyltransf_1 PF00583.25 CCF53985.1 - 3.4e-09 37.0 0.1 6.8e-09 36.0 0.1 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CCF53985.1 - 5.7e-06 26.3 0.0 1.1e-05 25.3 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CCF53985.1 - 0.0071 16.7 0.0 0.019 15.4 0.0 1.8 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain GCV_H PF01597.19 CCF53986.1 - 3.6e-43 146.3 0.1 4.3e-43 146.1 0.1 1.0 1 0 0 1 1 1 1 Glycine cleavage H-protein RnfC_N PF13375.6 CCF53986.1 - 3.9e-05 23.5 0.0 6.3e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 RnfC Barrel sandwich hybrid domain Biotin_lipoyl PF00364.22 CCF53986.1 - 0.00016 21.5 0.3 0.00026 20.8 0.3 1.3 1 0 0 1 1 1 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.6 CCF53986.1 - 0.17 11.7 1.0 14 5.6 0.3 2.3 1 1 1 2 2 2 0 Biotin-lipoyl like Mito_carr PF00153.27 CCF53988.1 - 1.1e-40 137.4 2.8 1.1e-14 54.0 0.0 3.6 3 1 0 3 3 3 3 Mitochondrial carrier protein DUF498 PF04430.14 CCF53989.1 - 2.9e-24 85.2 0.0 4.4e-24 84.6 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF498/DUF598) zf-C2H2 PF00096.26 CCF53990.1 - 3.8e-18 64.8 40.9 3.7e-05 23.9 0.6 9.3 8 0 0 8 8 8 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 CCF53990.1 - 5.4e-18 64.5 47.0 3.1e-08 33.7 1.8 7.2 9 0 0 9 9 7 4 Zinc-finger double domain zf-C2H2_6 PF13912.6 CCF53990.1 - 3.6e-05 23.6 25.2 0.0053 16.7 1.1 5.6 5 0 0 5 5 5 3 C2H2-type zinc finger zf-C2H2_4 PF13894.6 CCF53990.1 - 4.5e-05 23.9 72.0 0.0004 21.0 0.6 10.4 10 0 0 10 10 8 5 C2H2-type zinc finger FOXP-CC PF16159.5 CCF53990.1 - 9.9e-05 22.9 15.0 0.00089 19.8 2.3 7.9 5 1 2 8 8 6 3 FOXP coiled-coil domain zf-C2H2_jaz PF12171.8 CCF53990.1 - 0.0011 19.2 6.6 0.0052 17.0 0.2 4.0 4 0 0 4 4 4 1 Zinc-finger double-stranded RNA-binding zf-LYAR PF08790.11 CCF53990.1 - 0.023 14.6 0.8 0.023 14.6 0.8 5.4 6 0 0 6 6 6 0 LYAR-type C2HC zinc finger zf-C2H2_2 PF12756.7 CCF53990.1 - 0.03 14.7 0.4 0.03 14.7 0.4 5.4 6 0 0 6 6 5 0 C2H2 type zinc-finger (2 copies) MDMPI_N PF11716.8 CCF53990.1 - 0.078 13.7 1.0 0.14 12.8 1.0 1.4 1 0 0 1 1 1 0 Mycothiol maleylpyruvate isomerase N-terminal domain zf-C2H2_11 PF16622.5 CCF53990.1 - 0.14 12.0 0.2 0.14 12.0 0.2 5.0 5 0 0 5 5 4 0 zinc-finger C2H2-type zf_ZIC PF18366.1 CCF53990.1 - 0.18 12.0 10.0 0.56 10.3 0.0 5.3 4 1 1 5 5 5 0 Zic proteins zinc finger domain Zn-ribbon_8 PF09723.10 CCF53990.1 - 0.47 10.6 14.2 0.76 9.9 0.8 4.2 3 0 0 3 3 3 0 Zinc ribbon domain YhfH PF14149.6 CCF53990.1 - 2.2 8.3 8.9 1.1 9.2 0.1 3.7 4 0 0 4 4 4 0 YhfH-like protein Biotin_lipoyl PF00364.22 CCF53991.1 - 9.4e-22 76.6 1.3 2.2e-21 75.5 1.3 1.7 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.17 CCF53991.1 - 2.3e-08 34.2 0.0 5.7e-08 33.0 0.0 1.7 1 0 0 1 1 1 1 e3 binding domain Biotin_lipoyl_2 PF13533.6 CCF53991.1 - 1.9e-06 27.6 1.4 0.00013 21.8 0.0 3.1 2 1 1 3 3 3 1 Biotin-lipoyl like HlyD_3 PF13437.6 CCF53991.1 - 0.083 13.6 0.1 0.2 12.3 0.0 1.6 1 1 0 1 1 1 0 HlyD family secretion protein YqfD PF06898.11 CCF53991.1 - 0.11 11.3 0.2 0.19 10.5 0.2 1.3 1 0 0 1 1 1 0 Putative stage IV sporulation protein YqfD RNA_polI_A34 PF08208.11 CCF53992.1 - 1.1e-10 42.0 12.6 7.8e-10 39.2 12.6 2.2 1 1 0 1 1 1 1 DNA-directed RNA polymerase I subunit RPA34.5 adh_short PF00106.25 CCF53993.1 - 1.8e-19 70.0 2.7 7.1e-14 51.7 0.4 3.5 1 1 1 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CCF53993.1 - 2.3e-12 47.0 10.1 1.3e-06 28.2 1.9 4.0 3 1 0 3 3 3 3 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF53993.1 - 3.2e-06 27.2 2.4 0.0022 17.9 0.1 2.3 2 0 0 2 2 2 2 KR domain Oleosin PF01277.17 CCF53993.1 - 1.1 9.1 5.0 12 5.7 0.6 2.3 2 0 0 2 2 2 0 Oleosin TFB6 PF17110.5 CCF53994.1 - 6.7 6.4 20.9 0.97 9.2 5.9 4.7 2 2 1 3 3 3 0 Subunit 11 of the general transcription factor TFIIH 2OG-FeII_Oxy_2 PF13532.6 CCF53995.1 - 1.9e-12 47.8 1.4 3.3e-12 47.0 0.0 2.0 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily zf-C2HC5 PF06221.13 CCF53995.1 - 3.5 7.7 9.0 0.26 11.3 2.1 2.5 2 0 0 2 2 2 0 Putative zinc finger motif, C2HC5-type Pex14_N PF04695.13 CCF53995.1 - 5.5 7.6 12.7 2.7 8.7 0.1 3.0 3 0 0 3 3 3 0 Peroxisomal membrane anchor protein (Pex14p) conserved region RRM_1 PF00076.22 CCF53996.1 - 1.8e-23 82.1 0.0 5.3e-11 42.2 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PUF PF00806.19 CCF53996.1 - 2.1e-23 80.6 0.0 1.5e-05 24.4 0.0 5.8 5 0 0 5 5 5 5 Pumilio-family RNA binding repeat zf-RNPHF PF08080.12 CCF53996.1 - 0.00053 19.9 0.5 0.0015 18.5 0.5 1.8 1 0 0 1 1 1 1 RNPHF zinc finger RRM_occluded PF16842.5 CCF53996.1 - 0.0015 18.3 0.0 1.9 8.4 0.0 3.2 3 0 0 3 3 3 2 Occluded RNA-recognition motif zf-CCHC PF00098.23 CCF53997.1 - 1.3e-06 28.2 3.1 1.3e-06 28.2 3.1 2.0 2 0 0 2 2 2 1 Zinc knuckle Lipase_3 PF01764.25 CCF53999.1 - 1.7e-07 31.2 0.0 3.8e-07 30.1 0.0 1.5 1 0 0 1 1 1 1 Lipase (class 3) Hydrolase_4 PF12146.8 CCF53999.1 - 0.066 12.5 0.0 0.12 11.6 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 UPF0227 PF05728.12 CCF53999.1 - 0.14 12.1 0.0 0.26 11.2 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0227) SNARE_assoc PF09335.11 CCF54000.1 - 7.9e-18 65.1 9.0 7.9e-18 65.1 9.0 2.1 3 0 0 3 3 3 1 SNARE associated Golgi protein Saf_2TM PF18303.1 CCF54000.1 - 0.0088 15.6 0.6 0.023 14.3 0.6 1.6 1 0 0 1 1 1 1 SAVED-fused 2TM effector domain Pkinase PF00069.25 CCF54001.1 - 2.8e-26 92.4 0.0 3.6e-26 92.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF54001.1 - 3.1e-13 49.6 0.0 4.3e-13 49.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CCF54001.1 - 4.4e-07 29.0 0.8 6.7e-07 28.4 0.0 1.6 2 0 0 2 2 2 1 Fungal protein kinase DNA_pol_phi PF04931.13 CCF54002.1 - 1.1e-237 791.0 32.0 1.1e-237 791.0 32.0 2.9 2 2 0 2 2 2 1 DNA polymerase phi SDA1 PF05285.12 CCF54002.1 - 0.47 9.8 25.7 1.3 8.4 25.7 1.7 1 0 0 1 1 1 0 SDA1 Rhodanese PF00581.20 CCF54003.1 - 8.8e-11 42.3 0.0 2e-10 41.2 0.0 1.6 1 0 0 1 1 1 1 Rhodanese-like domain DEC-1_N PF04625.13 CCF54004.1 - 0.48 9.4 14.8 0.66 8.9 14.8 1.1 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region Acetyltransf_1 PF00583.25 CCF54005.1 - 1.2e-12 48.0 0.0 2.2e-12 47.2 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family HhH-GPD PF00730.25 CCF54005.1 - 5.9e-12 46.0 0.0 1.1e-10 41.9 0.0 2.4 2 0 0 2 2 2 1 HhH-GPD superfamily base excision DNA repair protein Acetyltransf_10 PF13673.7 CCF54005.1 - 3.5e-07 30.2 0.1 7.1e-07 29.2 0.1 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CCF54005.1 - 7.9e-07 29.4 0.1 1.5e-06 28.5 0.1 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CCF54005.1 - 3.7e-06 26.8 0.0 8.5e-06 25.7 0.0 1.5 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_4 PF13420.7 CCF54005.1 - 0.0052 16.9 0.0 0.01 16.0 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 CCF54005.1 - 0.081 13.1 0.0 0.18 11.9 0.0 1.5 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase HHH_2 PF12826.7 CCF54005.1 - 0.1 12.7 0.0 0.38 10.9 0.0 1.9 2 0 0 2 2 2 0 Helix-hairpin-helix motif NPR2 PF06218.11 CCF54006.1 - 8.8e-94 314.7 0.2 1.5e-38 132.8 0.0 5.4 4 2 1 5 5 5 4 Nitrogen permease regulator 2 Peptidase_M28 PF04389.17 CCF54007.1 - 2e-33 115.8 0.0 4e-33 114.8 0.0 1.5 1 1 0 1 1 1 1 Peptidase family M28 Homeodomain PF00046.29 CCF54008.1 - 2.2e-13 49.8 0.7 5.4e-13 48.6 0.7 1.7 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 CCF54008.1 - 0.00027 20.8 0.0 0.0008 19.3 0.0 1.8 1 0 0 1 1 1 1 Homeobox KN domain Sec63 PF02889.16 CCF54009.1 - 3.5e-73 246.0 0.0 5.5e-73 245.3 0.0 1.3 1 0 0 1 1 1 1 Sec63 Brl domain DEAD PF00270.29 CCF54009.1 - 2.3e-36 125.2 1.9 9.9e-27 93.8 0.1 3.0 3 0 0 3 3 3 2 DEAD/DEAH box helicase ResIII PF04851.15 CCF54009.1 - 2.7e-15 56.8 0.0 8.6e-11 42.1 0.0 2.6 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit Helicase_C PF00271.31 CCF54009.1 - 3.3e-07 30.6 0.3 4.1e-05 23.9 0.0 4.1 4 1 0 4 4 4 1 Helicase conserved C-terminal domain T2SSE PF00437.20 CCF54009.1 - 7.8e-06 25.1 1.3 0.0031 16.6 0.0 4.1 4 0 0 4 4 4 1 Type II/IV secretion system protein AAA_22 PF13401.6 CCF54009.1 - 8.8e-06 26.0 0.9 0.036 14.3 0.1 3.8 2 2 1 3 3 3 2 AAA domain IstB_IS21 PF01695.17 CCF54009.1 - 0.00018 21.3 0.4 0.83 9.4 0.1 3.0 3 0 0 3 3 3 2 IstB-like ATP binding protein AAA_7 PF12775.7 CCF54009.1 - 0.0014 18.2 0.2 0.095 12.2 0.1 2.5 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_29 PF13555.6 CCF54009.1 - 0.003 17.3 0.0 0.03 14.0 0.0 2.4 2 0 0 2 2 2 1 P-loop containing region of AAA domain Helicase_RecD PF05127.14 CCF54009.1 - 0.0094 15.8 0.6 2.5 7.9 0.0 3.2 2 1 0 2 2 2 1 Helicase Helicase_PWI PF18149.1 CCF54009.1 - 0.014 15.6 0.0 0.063 13.5 0.0 2.2 1 0 0 1 1 1 0 N-terminal helicase PWI domain AAA_23 PF13476.6 CCF54009.1 - 0.032 14.7 0.6 2.5 8.6 0.0 3.1 3 0 0 3 3 3 0 AAA domain PhoH PF02562.16 CCF54009.1 - 0.049 13.1 0.3 4.5 6.7 0.1 2.4 2 0 0 2 2 2 0 PhoH-like protein TniB PF05621.11 CCF54009.1 - 0.1 12.0 0.4 11 5.3 0.1 3.5 3 0 0 3 3 3 0 Bacterial TniB protein PheRS_DBD1 PF18552.1 CCF54009.1 - 0.15 11.9 0.2 0.62 9.9 0.1 2.1 1 1 1 2 2 2 0 PheRS DNA binding domain 1 ApbA_C PF08546.11 CCF54010.1 - 6.6e-26 91.0 0.0 9.9e-26 90.4 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal ApbA PF02558.16 CCF54010.1 - 3.4e-18 65.8 0.0 5.3e-18 65.1 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA Synaptobrevin PF00957.21 CCF54011.1 - 2.6e-26 91.2 0.0 3.6e-26 90.8 0.0 1.2 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.6 CCF54011.1 - 1.2e-18 67.0 0.0 1.9e-18 66.3 0.0 1.4 1 0 0 1 1 1 1 Regulated-SNARE-like domain DUF600 PF04634.12 CCF54011.1 - 0.16 12.0 0.0 0.29 11.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF600 AMP-binding PF00501.28 CCF54012.1 - 1.5e-43 149.0 0.0 2.1e-43 148.5 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme ACAS_N PF16177.5 CCF54012.1 - 1.5e-05 24.8 0.0 2.8e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 Acetyl-coenzyme A synthetase N-terminus Tom37 PF10568.9 CCF54014.1 - 7.6e-13 48.9 0.8 5.1e-12 46.2 0.5 2.4 2 0 0 2 2 2 1 Outer mitochondrial membrane transport complex protein Lactonase PF10282.9 CCF54014.1 - 6.9e-07 28.8 0.2 4.5e-06 26.2 0.0 2.2 2 0 0 2 2 2 1 Lactonase, 7-bladed beta-propeller GST_C_6 PF17171.4 CCF54014.1 - 8.4e-07 28.7 0.0 2.2e-06 27.3 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain tRNA_Me_trans PF03054.16 CCF54015.1 - 1.4e-106 356.3 0.0 1.6e-106 356.1 0.0 1.0 1 0 0 1 1 1 1 tRNA methyl transferase NAD_synthase PF02540.17 CCF54015.1 - 0.0007 18.8 0.1 0.2 10.8 0.0 2.3 2 0 0 2 2 2 2 NAD synthase Asn_synthase PF00733.21 CCF54015.1 - 0.044 13.4 0.2 0.074 12.7 0.2 1.3 1 0 0 1 1 1 0 Asparagine synthase SAP PF02037.27 CCF54015.1 - 0.093 12.5 0.1 0.19 11.5 0.1 1.5 1 0 0 1 1 1 0 SAP domain CENP-C_C PF11699.8 CCF54016.1 - 1.3e-29 102.2 0.0 2.2e-29 101.5 0.0 1.4 1 0 0 1 1 1 1 Mif2/CENP-C like Cupin_2 PF07883.11 CCF54016.1 - 0.0012 18.5 0.0 0.0023 17.6 0.0 1.4 1 0 0 1 1 1 1 Cupin domain PTCB-BRCT PF12738.7 CCF54017.1 - 1.2e-32 111.6 0.0 2.3e-12 46.7 0.0 4.5 4 0 0 4 4 4 4 twin BRCT domain BRCT PF00533.26 CCF54017.1 - 5.2e-23 81.2 0.0 4.1e-10 39.9 0.0 4.8 5 0 0 5 5 5 4 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 CCF54017.1 - 1.1e-09 38.6 0.0 1.6 9.2 0.0 5.0 5 0 0 5 5 5 4 BRCT domain, a BRCA1 C-terminus domain LIG3_BRCT PF16759.5 CCF54017.1 - 7.3e-07 29.4 0.0 5.2 7.4 0.0 5.4 5 1 0 5 5 5 3 DNA ligase 3 BRCT domain RTT107_BRCT_5 PF16770.5 CCF54017.1 - 0.0055 16.6 0.0 0.62 10.0 0.0 3.1 3 0 0 3 3 3 1 Regulator of Ty1 transposition protein 107 BRCT domain CLTH PF10607.9 CCF54019.1 - 8.8e-21 74.3 0.0 1.2e-20 73.9 0.0 1.2 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain LisH PF08513.11 CCF54019.1 - 0.0059 16.5 0.0 0.015 15.3 0.0 1.7 1 0 0 1 1 1 1 LisH WD40 PF00400.32 CCF54020.1 - 1.2e-14 54.4 7.4 0.011 16.6 0.3 6.0 6 0 0 6 6 6 3 WD domain, G-beta repeat Nucleoporin_N PF08801.11 CCF54020.1 - 0.02 13.7 0.2 1 8.0 0.1 2.2 2 0 0 2 2 2 0 Nup133 N terminal like Nup160 PF11715.8 CCF54020.1 - 0.3 9.7 7.0 3.9 6.0 0.2 3.0 1 1 2 3 3 3 0 Nucleoporin Nup120/160 Pns11_12 PF17464.2 CCF54020.1 - 0.61 9.8 5.0 1.2 8.8 5.0 1.4 1 0 0 1 1 1 0 Non-structural protein 11 and 12 Brix PF04427.18 CCF54021.1 - 9.1e-42 143.3 0.0 1.4e-41 142.8 0.0 1.3 1 0 0 1 1 1 1 Brix domain BUD22 PF09073.10 CCF54021.1 - 0.62 9.3 28.4 0.93 8.8 28.4 1.3 1 0 0 1 1 1 0 BUD22 Nop14 PF04147.12 CCF54021.1 - 0.69 8.0 36.6 0.95 7.6 36.6 1.1 1 0 0 1 1 1 0 Nop14-like family BSP_II PF05432.11 CCF54021.1 - 2.2 7.9 23.2 3.9 7.1 23.2 1.4 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) TFIIA PF03153.13 CCF54021.1 - 3.6 7.5 24.1 7.4 6.4 24.1 1.6 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CNDH2_C PF16858.5 CCF54021.1 - 5.3 6.8 13.8 9.2 6.0 13.8 1.3 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term CobT PF06213.12 CCF54021.1 - 5.7 6.2 26.0 8.8 5.6 26.0 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Peptidase_S28 PF05577.12 CCF54022.1 - 3.1e-39 135.0 0.0 2.6e-34 118.7 0.0 2.5 2 1 0 2 2 2 2 Serine carboxypeptidase S28 Ras PF00071.22 CCF54023.1 - 2.5e-53 180.0 0.0 2.8e-53 179.8 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CCF54023.1 - 4e-19 69.0 0.0 5.4e-19 68.6 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CCF54023.1 - 1.6e-06 27.7 0.0 2.2e-06 27.2 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Rnk_N PF14760.6 CCF54023.1 - 0.037 14.5 0.6 0.29 11.6 0.1 2.1 2 0 0 2 2 2 0 Rnk N-terminus GTP_EFTU PF00009.27 CCF54023.1 - 0.15 11.5 0.1 1.6 8.3 0.0 2.4 1 1 0 2 2 2 0 Elongation factor Tu GTP binding domain zf-C3HC4_3 PF13920.6 CCF54024.1 - 0.00031 20.5 7.9 0.00052 19.8 7.9 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CCF54024.1 - 0.035 14.0 11.3 0.056 13.3 11.3 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 CCF54024.1 - 7.5 6.5 13.8 0.079 12.8 5.4 1.9 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Pex2_Pex12 PF04757.14 CCF54025.1 - 3.5e-46 157.6 6.6 4.4e-46 157.3 6.6 1.1 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-C3HC4_3 PF13920.6 CCF54025.1 - 7e-05 22.6 0.5 0.00011 22.0 0.5 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CCF54025.1 - 0.0033 17.7 0.9 0.006 16.9 0.9 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 CCF54025.1 - 0.0077 16.1 2.3 0.016 15.0 2.3 1.6 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CCF54025.1 - 0.023 14.5 0.9 0.038 13.9 0.9 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 CCF54025.1 - 0.048 13.8 3.9 0.085 13.0 3.9 1.4 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.6 CCF54025.1 - 1 9.5 3.3 1.9 8.6 3.3 1.4 1 0 0 1 1 1 0 RING-type zinc-finger UCH PF00443.29 CCF54026.1 - 2.9e-38 131.9 0.0 5.2e-38 131.0 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP_var PF17807.1 CCF54026.1 - 2.3e-24 84.9 2.7 5.3e-23 80.5 0.5 2.6 2 0 0 2 2 2 1 Variant UBP zinc finger zf-UBP PF02148.19 CCF54026.1 - 2.4e-23 82.2 12.2 1.6e-18 66.8 1.6 3.1 3 0 0 3 3 3 2 Zn-finger in ubiquitin-hydrolases and other protein UBA PF00627.31 CCF54026.1 - 2.4e-15 56.1 0.4 8.7e-08 31.9 0.0 2.5 2 0 0 2 2 2 2 UBA/TS-N domain UCH_1 PF13423.6 CCF54026.1 - 1.9e-11 44.2 0.8 5e-10 39.5 0.8 2.8 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase PalH PF08733.10 CCF54027.1 - 0.62 9.0 5.1 1.6 7.7 5.1 1.7 1 1 0 1 1 1 0 PalH/RIM21 Fungal_trans PF04082.18 CCF54028.1 - 9.6e-09 34.6 0.3 2.8e-08 33.1 0.1 1.9 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF54028.1 - 4.5e-06 26.7 9.2 8.8e-06 25.7 9.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Flg_hook PF02120.16 CCF54028.1 - 0.22 11.4 3.2 4.2 7.3 0.0 2.7 2 0 0 2 2 2 0 Flagellar hook-length control protein FliK Met_10 PF02475.16 CCF54029.1 - 7.9e-51 172.6 0.0 2.4e-50 171.0 0.0 1.8 1 1 0 1 1 1 1 Met-10+ like-protein Gag_p17 PF00540.18 CCF54029.1 - 0.062 13.3 1.1 0.14 12.1 0.0 2.1 3 0 0 3 3 3 0 gag gene protein p17 (matrix protein) PIG-L PF02585.17 CCF54030.1 - 1.4e-23 84.0 0.0 1.9e-23 83.5 0.0 1.2 1 0 0 1 1 1 1 GlcNAc-PI de-N-acetylase GAD-like PF08887.11 CCF54030.1 - 0.12 12.2 0.1 0.21 11.4 0.1 1.4 1 0 0 1 1 1 0 GAD-like domain TFIIE-A_C PF11521.8 CCF54031.1 - 0.16 12.3 3.7 0.23 11.8 1.5 2.5 2 0 0 2 2 2 0 C-terminal general transcription factor TFIIE alpha LIF_OSM PF01291.17 CCF54031.1 - 0.16 12.1 0.0 0.34 11.0 0.0 1.5 1 0 0 1 1 1 0 LIF / OSM family Chorismate_bind PF00425.18 CCF54032.1 - 3.1e-88 295.7 0.0 4.5e-88 295.2 0.0 1.2 1 0 0 1 1 1 1 chorismate binding enzyme Anth_synt_I_N PF04715.13 CCF54032.1 - 6.8e-27 94.4 0.0 2.2e-26 92.8 0.0 1.9 1 0 0 1 1 1 1 Anthranilate synthase component I, N terminal region PRP21_like_P PF12230.8 CCF54033.1 - 4.2e-42 144.5 3.5 4.2e-42 144.5 3.5 1.8 2 0 0 2 2 2 1 Pre-mRNA splicing factor PRP21 like protein Surp PF01805.20 CCF54033.1 - 1.3e-30 105.2 2.7 1.2e-14 54.1 0.1 2.5 2 0 0 2 2 2 2 Surp module CTI PF06934.11 CCF54033.1 - 0.011 14.3 0.1 0.019 13.5 0.1 1.3 1 0 0 1 1 1 0 Fatty acid cis/trans isomerase (CTI) zf-Di19 PF05605.12 CCF54033.1 - 0.19 12.0 0.1 0.34 11.2 0.1 1.3 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding Toprim_Crpt PF13342.6 CCF54033.1 - 0.85 9.6 2.6 8.9 6.4 0.3 2.4 2 0 0 2 2 2 0 C-terminal repeat of topoisomerase AP_endonuc_2 PF01261.24 CCF54035.1 - 2e-29 102.5 0.0 5e-29 101.2 0.0 1.6 1 1 0 1 1 1 1 Xylose isomerase-like TIM barrel WD40 PF00400.32 CCF54037.1 - 2e-11 44.2 9.1 0.0019 19.0 0.2 5.0 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF54037.1 - 9.4e-07 29.1 0.1 0.003 17.8 0.0 3.1 3 0 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Asn_synthase PF00733.21 CCF54038.1 - 4.2e-93 312.8 0.7 2.8e-56 191.7 0.0 3.1 2 1 1 3 3 3 3 Asparagine synthase GATase_7 PF13537.6 CCF54038.1 - 8.5e-38 129.0 0.0 1.3e-37 128.4 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.6 CCF54038.1 - 1.5e-30 106.1 0.0 3.2e-30 105.1 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain DUF3700 PF12481.8 CCF54038.1 - 2.6e-05 23.8 0.0 5.9e-05 22.6 0.0 1.5 1 0 0 1 1 1 1 Aluminium induced protein NAD_synthase PF02540.17 CCF54038.1 - 0.018 14.2 0.0 0.042 13.0 0.0 1.5 2 0 0 2 2 2 0 NAD synthase DUF1776 PF08643.10 CCF54039.1 - 6e-05 22.6 0.0 0.2 11.0 0.0 2.2 2 0 0 2 2 2 2 Fungal family of unknown function (DUF1776) adh_short PF00106.25 CCF54039.1 - 0.018 14.5 0.0 0.18 11.2 0.0 2.2 2 0 0 2 2 2 0 short chain dehydrogenase DEAD PF00270.29 CCF54040.1 - 2.2e-50 170.8 0.0 1.3e-49 168.3 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CCF54040.1 - 8.8e-31 106.5 0.0 2e-29 102.2 0.0 2.4 2 1 1 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 CCF54040.1 - 4e-06 26.9 0.0 2.2e-05 24.6 0.0 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Helicase_C_2 PF13307.6 CCF54040.1 - 0.017 15.3 0.0 0.029 14.5 0.0 1.3 1 0 0 1 1 1 0 Helicase C-terminal domain AAA_19 PF13245.6 CCF54040.1 - 0.06 13.7 0.0 16 5.8 0.0 2.4 2 0 0 2 2 2 0 AAA domain BATS PF06968.13 CCF54041.1 - 2.2e-19 69.3 0.3 8.9e-19 67.4 0.1 2.2 2 0 0 2 2 2 1 Biotin and Thiamin Synthesis associated domain Radical_SAM PF04055.21 CCF54041.1 - 5.2e-13 49.7 0.1 9.5e-13 48.9 0.1 1.3 1 0 0 1 1 1 1 Radical SAM superfamily Zn_clus PF00172.18 CCF54042.1 - 9.8e-10 38.4 29.4 1.1e-07 31.8 8.8 3.0 2 1 0 2 2 2 2 Fungal Zn(2)-Cys(6) binuclear cluster domain F-box_4 PF15966.5 CCF54044.1 - 0.12 12.2 0.2 0.5 10.3 0.0 2.0 2 0 0 2 2 2 0 F-box RL10P_insert PF17777.1 CCF54045.1 - 9.2e-22 76.8 0.1 1.4e-21 76.3 0.1 1.3 1 0 0 1 1 1 1 Insertion domain in 60S ribosomal protein L10P Ribosomal_L10 PF00466.20 CCF54045.1 - 1.4e-17 63.7 0.0 2.5e-17 62.9 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L10 NOA36 PF06524.12 CCF54045.1 - 1.1 8.5 13.3 1.7 7.9 13.3 1.2 1 0 0 1 1 1 0 NOA36 protein RXT2_N PF08595.11 CCF54045.1 - 1.2 9.2 6.0 2.5 8.1 6.0 1.5 1 0 0 1 1 1 0 RXT2-like, N-terminal DUF4637 PF15470.6 CCF54045.1 - 6.6 6.4 8.2 88 2.8 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4637) HEAT_2 PF13646.6 CCF54046.1 - 2.3e-24 85.6 4.2 4.3e-13 49.4 1.1 2.6 2 0 0 2 2 2 2 HEAT repeats HEAT_PBS PF03130.16 CCF54046.1 - 1.3e-17 62.6 1.0 0.0023 18.4 0.0 6.7 7 0 0 7 7 7 4 PBS lyase HEAT-like repeat HEAT PF02985.22 CCF54046.1 - 2.4e-13 49.1 2.1 0.047 13.9 0.0 6.3 6 0 0 6 6 6 4 HEAT repeat HEAT_EZ PF13513.6 CCF54046.1 - 0.013 16.0 2.2 5.4 7.6 0.0 4.5 2 2 3 5 5 5 0 HEAT-like repeat Arm PF00514.23 CCF54046.1 - 0.11 12.6 0.1 33 4.7 0.0 3.3 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat CLTH PF10607.9 CCF54047.1 - 2.9e-29 101.8 0.0 3.8e-29 101.5 0.0 1.2 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain LisH PF08513.11 CCF54047.1 - 3.6e-10 39.4 0.1 1e-09 38.0 0.0 1.9 2 0 0 2 2 2 1 LisH DWNN PF08783.11 CCF54048.1 - 3.6e-34 116.9 0.0 6.7e-34 116.0 0.0 1.5 1 0 0 1 1 1 1 DWNN domain zf-CCHC_2 PF13696.6 CCF54048.1 - 2.5e-11 43.2 4.3 4.4e-11 42.4 4.3 1.4 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC PF00098.23 CCF54048.1 - 2.4e-06 27.4 0.8 5.1e-06 26.3 0.8 1.6 1 0 0 1 1 1 1 Zinc knuckle U-box PF04564.15 CCF54048.1 - 0.00012 22.2 0.9 0.012 15.8 0.0 2.9 2 1 1 3 3 2 1 U-box domain zf-C3HC4_3 PF13920.6 CCF54048.1 - 0.0046 16.8 10.1 0.0046 16.8 10.1 1.6 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-CCHC_5 PF14787.6 CCF54048.1 - 0.0089 15.7 2.7 0.01 15.5 0.8 2.1 2 0 0 2 2 2 1 GAG-polyprotein viral zinc-finger zf-CCHC_3 PF13917.6 CCF54048.1 - 0.018 15.0 0.1 0.061 13.3 0.1 1.9 1 0 0 1 1 1 0 Zinc knuckle TetR_C_23 PF17931.1 CCF54048.1 - 0.074 13.2 0.7 0.14 12.2 0.7 1.4 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain Borrelia_P83 PF05262.11 CCF54048.1 - 0.1 11.1 2.6 0.15 10.5 2.6 1.2 1 0 0 1 1 1 0 Borrelia P83/100 protein Frigida PF07899.11 CCF54048.1 - 0.11 11.7 1.5 0.21 10.9 1.5 1.4 1 0 0 1 1 1 0 Frigida-like protein Siva PF05458.12 CCF54048.1 - 0.11 12.1 4.6 0.31 10.7 4.6 1.7 1 0 0 1 1 1 0 Cd27 binding protein (Siva) zf-RING_2 PF13639.6 CCF54048.1 - 0.21 11.9 12.1 0.44 10.9 12.1 1.6 1 0 0 1 1 1 0 Ring finger domain zf-C3HC4 PF00097.25 CCF54048.1 - 1.6 8.7 15.0 3 7.8 15.0 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 CCF54048.1 - 1.8 8.8 13.4 4.1 7.6 13.4 1.7 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING AIF-MLS PF14962.6 CCF54048.1 - 2 8.3 7.8 4.8 7.1 7.8 1.6 1 0 0 1 1 1 0 Mitochondria Localisation Sequence zf-C3HC4_2 PF13923.6 CCF54048.1 - 2.2 8.2 21.2 0.027 14.3 13.8 1.7 2 0 0 2 2 1 0 Zinc finger, C3HC4 type (RING finger) Vfa1 PF08432.10 CCF54048.1 - 2.6 8.3 12.0 6.2 7.1 12.0 1.6 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Plasmodium_Vir PF05795.11 CCF54048.1 - 4.2 6.7 8.8 6.9 6.0 8.8 1.2 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Trm112p PF03966.16 CCF54048.1 - 7.2 7.3 6.2 18 6.0 6.2 1.6 1 0 0 1 1 1 0 Trm112p-like protein zf_UBZ PF18439.1 CCF54048.1 - 7.6 6.2 9.1 1.9 8.2 0.3 3.3 2 1 1 3 3 3 0 Ubiquitin-Binding Zinc Finger LCAT PF02450.15 CCF54049.1 - 2e-89 300.5 0.2 1.3e-88 297.8 0.2 1.9 1 1 0 1 1 1 1 Lecithin:cholesterol acyltransferase MOR2-PAG1_N PF14222.6 CCF54050.1 - 1.9e-125 419.9 0.0 3.7e-125 419.0 0.0 1.5 1 0 0 1 1 1 1 Cell morphogenesis N-terminal MOR2-PAG1_C PF14225.6 CCF54050.1 - 1.2e-93 313.6 1.6 8.1e-93 310.9 0.1 2.8 3 0 0 3 3 3 1 Cell morphogenesis C-terminal MOR2-PAG1_mid PF14228.6 CCF54050.1 - 5.2e-29 100.6 1.1 9.3e-14 50.1 0.0 4.2 4 0 0 4 4 4 4 Cell morphogenesis central region HEAT_2 PF13646.6 CCF54050.1 - 0.23 11.9 4.5 10 6.6 0.0 5.5 5 1 1 6 6 6 0 HEAT repeats Acid_PPase PF12689.7 CCF54051.1 - 1.6e-54 184.2 0.0 2e-54 183.9 0.0 1.1 1 0 0 1 1 1 1 Acid Phosphatase Pex2_Pex12 PF04757.14 CCF54052.1 - 3.6e-33 115.0 6.8 4.9e-33 114.6 6.8 1.2 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-C3HC4_2 PF13923.6 CCF54052.1 - 0.00031 20.5 1.5 0.0064 16.3 0.2 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CCF54052.1 - 0.00041 20.2 0.8 0.0026 17.6 0.1 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CCF54052.1 - 0.0017 18.3 0.5 0.025 14.6 0.1 2.4 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_2 PF13639.6 CCF54052.1 - 0.0089 16.3 0.9 0.45 10.9 0.1 2.4 2 0 0 2 2 2 1 Ring finger domain Fer2 PF00111.27 CCF54052.1 - 0.1 12.6 0.7 0.26 11.3 0.7 1.7 1 0 0 1 1 1 0 2Fe-2S iron-sulfur cluster binding domain zf-RING_5 PF14634.6 CCF54052.1 - 0.15 12.0 3.5 0.26 11.3 0.9 2.2 2 0 0 2 2 2 0 zinc-RING finger domain PBP PF01161.20 CCF54053.1 - 4.4e-08 33.5 0.0 6.9e-08 32.9 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein DnaJ PF00226.31 CCF54054.1 - 5e-18 65.0 0.2 1.1e-17 63.9 0.0 1.7 2 0 0 2 2 2 1 DnaJ domain RIX1 PF08167.12 CCF54055.1 - 2.1e-37 128.7 4.4 2.1e-37 128.7 4.4 2.3 2 0 0 2 2 2 1 rRNA processing/ribosome biogenesis Sec10 PF07393.11 CCF54056.1 - 1.6e-282 939.2 0.0 1.9e-282 938.9 0.0 1.1 1 0 0 1 1 1 1 Exocyst complex component Sec10 DUF1664 PF07889.12 CCF54056.1 - 0.017 15.2 0.5 0.039 14.0 0.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Spectrin PF00435.21 CCF54056.1 - 0.19 12.3 0.1 0.52 10.8 0.1 1.8 1 0 0 1 1 1 0 Spectrin repeat Dor1 PF04124.12 CCF54056.1 - 0.26 9.9 1.1 0.6 8.7 1.1 1.5 1 0 0 1 1 1 0 Dor1-like family Glyco_hydro_16 PF00722.21 CCF54057.1 - 2e-34 118.6 5.2 2.9e-34 118.1 5.2 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 Chitin_bind_1 PF00187.19 CCF54057.1 - 0.00065 20.1 12.8 0.0014 19.0 12.8 1.5 1 0 0 1 1 1 1 Chitin recognition protein DUF1080 PF06439.11 CCF54057.1 - 0.0022 18.2 0.9 0.0035 17.5 0.9 1.4 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1080) Peptidase_C37 PF05416.12 CCF54058.1 - 0.04 12.4 0.1 0.075 11.5 0.1 1.4 1 0 0 1 1 1 0 Southampton virus-type processing peptidase TPR_16 PF13432.6 CCF54059.1 - 2.8e-19 69.5 10.0 0.00036 21.1 0.0 7.5 6 1 1 7 7 7 5 Tetratricopeptide repeat TPR_2 PF07719.17 CCF54059.1 - 8e-18 63.1 20.8 0.022 14.8 0.1 10.6 11 0 0 11 11 10 5 Tetratricopeptide repeat TPR_19 PF14559.6 CCF54059.1 - 1.1e-15 57.8 15.9 6.3e-06 26.6 2.1 7.1 6 1 1 7 7 6 3 Tetratricopeptide repeat TPR_8 PF13181.6 CCF54059.1 - 6e-13 47.9 8.5 0.32 11.3 0.1 8.4 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_1 PF00515.28 CCF54059.1 - 1.7e-11 43.4 13.6 0.019 14.7 0.1 9.1 10 0 0 10 10 10 2 Tetratricopeptide repeat TPR_11 PF13414.6 CCF54059.1 - 2.1e-11 43.3 0.1 0.0098 15.6 0.1 5.1 4 1 1 5 5 5 3 TPR repeat TPR_14 PF13428.6 CCF54059.1 - 1.9e-09 37.6 19.8 0.0018 18.9 0.7 10.0 7 2 3 10 10 9 2 Tetratricopeptide repeat TPR_12 PF13424.6 CCF54059.1 - 2.5e-08 34.1 24.3 0.00037 20.7 0.4 7.9 5 3 2 8 8 8 3 Tetratricopeptide repeat TPR_17 PF13431.6 CCF54059.1 - 4.8e-07 29.7 0.2 0.34 11.4 0.0 5.0 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_6 PF13174.6 CCF54059.1 - 1.1e-06 28.9 10.8 7 7.5 0.0 9.3 10 0 0 10 10 9 1 Tetratricopeptide repeat TPR_9 PF13371.6 CCF54059.1 - 2e-06 27.9 8.9 0.00069 19.7 0.2 5.3 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_15 PF13429.6 CCF54059.1 - 2.5e-05 23.6 3.4 0.0064 15.7 0.9 3.4 3 1 0 4 4 4 2 Tetratricopeptide repeat TPR_20 PF14561.6 CCF54059.1 - 5.8e-05 23.3 5.9 0.42 11.0 0.0 5.2 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.6 CCF54059.1 - 0.0011 18.9 10.0 18 5.7 0.1 7.2 7 0 0 7 7 6 0 Tetratricopeptide repeat ANAPC3 PF12895.7 CCF54059.1 - 0.0069 16.6 9.7 0.35 11.1 1.3 4.8 5 2 2 7 7 5 1 Anaphase-promoting complex, cyclosome, subunit 3 Alkyl_sulf_dimr PF14863.6 CCF54059.1 - 0.03 14.8 0.7 7.8 7.0 0.1 2.7 2 0 0 2 2 2 0 Alkyl sulfatase dimerisation Vps39_1 PF10366.9 CCF54059.1 - 0.054 13.8 0.0 5.4 7.4 0.0 2.7 2 0 0 2 2 2 0 Vacuolar sorting protein 39 domain 1 TPR_10 PF13374.6 CCF54059.1 - 1.8 8.6 10.8 34 4.5 0.0 6.4 6 0 0 6 6 6 0 Tetratricopeptide repeat NARP1 PF12569.8 CCF54059.1 - 4.8 6.0 16.1 0.21 10.5 1.7 3.9 2 1 3 5 5 5 0 NMDA receptor-regulated protein 1 Nup88 PF10168.9 CCF54060.1 - 3.8e-21 74.6 6.7 3.5e-15 54.9 0.0 2.7 2 1 0 2 2 2 2 Nuclear pore component FadA PF09403.10 CCF54060.1 - 0.055 14.0 1.9 1.3 9.6 0.0 2.6 2 0 0 2 2 2 0 Adhesion protein FadA DUF948 PF06103.11 CCF54060.1 - 0.36 11.1 1.6 8.5 6.7 0.1 2.7 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Laminin_II PF06009.12 CCF54060.1 - 1.1 9.3 8.2 7.9 6.5 2.9 2.7 2 1 0 2 2 2 0 Laminin Domain II 4HBT_3 PF13622.6 CCF54061.1 - 1.2e-57 196.1 0.0 1.8e-57 195.4 0.0 1.2 1 0 0 1 1 1 1 Thioesterase-like superfamily Acyl_CoA_thio PF02551.15 CCF54061.1 - 8.2e-29 100.1 0.0 3.7e-22 78.6 0.0 3.2 2 1 0 2 2 2 2 Acyl-CoA thioesterase Sec1 PF00995.23 CCF54062.1 - 6.6e-124 415.2 0.0 7.6e-124 415.0 0.0 1.0 1 0 0 1 1 1 1 Sec1 family Pkinase PF00069.25 CCF54064.1 - 9e-36 123.6 0.0 1.6e-21 76.9 0.0 3.3 3 0 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.17 CCF54064.1 - 6e-17 61.8 0.0 4.2e-16 59.0 0.0 2.1 2 0 0 2 2 2 1 Protein tyrosine kinase FAM176 PF14851.6 CCF54064.1 - 3.4 7.3 5.6 13 5.4 5.6 2.0 1 0 0 1 1 1 0 FAM176 family UQ_con PF00179.26 CCF54065.1 - 7.4e-44 148.8 0.0 8.5e-44 148.6 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Syntaxin-18_N PF10496.9 CCF54066.1 - 5.9e-14 52.1 0.7 6.9e-13 48.7 0.0 3.0 3 0 0 3 3 3 1 SNARE-complex protein Syntaxin-18 N-terminus SNARE PF05739.19 CCF54066.1 - 0.02 14.9 0.0 0.097 12.7 0.0 2.1 2 0 0 2 2 2 0 SNARE domain LCIB_C_CA PF18599.1 CCF54066.1 - 0.18 11.1 0.2 4.6 6.5 0.2 2.2 2 0 0 2 2 2 0 Limiting CO2-inducible proteins B/C beta carbonyic anhydrases Glyco_transf_22 PF03901.17 CCF54067.1 - 6e-35 121.3 10.6 8.1e-35 120.8 10.6 1.1 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family XAP5 PF04921.14 CCF54068.1 - 1.4e-86 290.4 7.1 1.4e-86 290.4 7.1 2.0 1 1 1 2 2 2 1 XAP5, circadian clock regulator ACT_7 PF13840.6 CCF54069.1 - 7.1e-12 44.9 0.0 1.3e-11 44.1 0.0 1.4 1 0 0 1 1 1 1 ACT domain Sld5 PF05916.11 CCF54072.1 - 7.1e-10 39.3 0.1 1.2e-09 38.6 0.1 1.6 1 1 0 1 1 1 1 GINS complex protein AA_permease PF00324.21 CCF54073.1 - 4.3e-137 457.6 39.5 4.9e-137 457.4 39.5 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 CCF54073.1 - 1.1e-44 152.9 45.0 1.5e-44 152.5 45.0 1.1 1 0 0 1 1 1 1 Amino acid permease Presenilin PF01080.17 CCF54073.1 - 0.13 11.0 1.8 1.4 7.6 0.3 2.5 2 0 0 2 2 2 0 Presenilin Flavin_Reduct PF01613.18 CCF54075.1 - 1.9e-18 67.0 0.1 2.8e-18 66.4 0.1 1.1 1 0 0 1 1 1 1 Flavin reductase like domain Methyltransf_12 PF08242.12 CCF54076.1 - 8e-17 61.8 0.3 1.8e-16 60.6 0.0 1.8 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCF54076.1 - 3.1e-16 59.7 0.9 4.8e-16 59.0 0.9 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF54076.1 - 1.5e-14 54.5 0.0 2.9e-14 53.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF54076.1 - 1.9e-14 54.1 0.0 3.5e-14 53.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF54076.1 - 5.8e-13 48.9 0.1 9e-13 48.3 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CCF54076.1 - 1e-07 31.5 0.0 1.6e-07 30.9 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family DREV PF05219.12 CCF54076.1 - 7.9e-06 25.2 0.0 0.0003 20.0 0.0 2.1 1 1 0 1 1 1 1 DREV methyltransferase MTS PF05175.14 CCF54076.1 - 3.5e-05 23.4 0.0 7.4e-05 22.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase small domain Cons_hypoth95 PF03602.15 CCF54076.1 - 0.00046 19.9 0.0 0.00068 19.3 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical protein 95 DUF938 PF06080.12 CCF54076.1 - 0.0012 18.6 0.0 0.0018 18.1 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF938) RrnaAD PF00398.20 CCF54076.1 - 0.0016 17.6 0.0 0.0035 16.5 0.0 1.5 2 0 0 2 2 2 1 Ribosomal RNA adenine dimethylase Polysacc_synt_2 PF02719.15 CCF54076.1 - 0.0095 15.1 0.0 0.015 14.5 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NPV_P10 PF05531.12 CCF54076.1 - 0.014 15.8 0.1 0.038 14.5 0.1 1.7 1 0 0 1 1 1 0 Nucleopolyhedrovirus P10 protein NodS PF05401.11 CCF54076.1 - 0.019 14.6 0.0 0.031 13.9 0.0 1.3 1 0 0 1 1 1 0 Nodulation protein S (NodS) DRE2_N PF16803.5 CCF54076.1 - 0.021 15.1 0.1 0.1 12.8 0.0 2.0 2 0 0 2 2 2 0 Fe-S cluster assembly protein DRE2 N-terminus MetOD2 PF18548.1 CCF54076.1 - 0.11 12.6 0.0 0.3 11.2 0.0 1.7 1 0 0 1 1 1 0 Metanogen output domain 2 Zip PF02535.22 CCF54076.1 - 0.34 10.1 5.9 0.48 9.6 5.9 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter SelP_N PF04592.14 CCF54076.1 - 1.8 7.9 21.5 1.6 8.0 19.8 1.8 2 0 0 2 2 2 0 Selenoprotein P, N terminal region TFCD_C PF12612.8 CCF54078.1 - 4.7e-42 144.0 0.0 1.7e-40 138.9 0.0 3.6 4 0 0 4 4 4 1 Tubulin folding cofactor D C terminal RTP1_C1 PF10363.9 CCF54078.1 - 7.7e-05 22.8 1.9 0.0097 16.1 0.0 4.3 5 1 1 6 6 6 1 Required for nuclear transport of RNA pol II C-terminus 1 HEAT PF02985.22 CCF54078.1 - 0.0058 16.8 0.0 0.0058 16.8 0.0 8.4 9 0 0 9 9 9 1 HEAT repeat Cnd1 PF12717.7 CCF54078.1 - 0.044 13.8 1.6 9.6 6.2 0.0 4.0 5 1 0 5 5 5 0 non-SMC mitotic condensation complex subunit 1 TAF6_C PF07571.13 CCF54078.1 - 0.11 12.8 0.3 43 4.5 0.0 4.0 3 0 0 3 3 3 0 TAF6 C-terminal HEAT repeat domain HEAT_PBS PF03130.16 CCF54078.1 - 0.22 12.3 0.0 0.22 12.3 0.0 5.4 6 0 0 6 6 6 0 PBS lyase HEAT-like repeat HEAT_2 PF13646.6 CCF54078.1 - 0.23 11.9 0.0 0.16 12.4 0.2 7.3 6 1 2 8 8 8 0 HEAT repeats Lipase_3 PF01764.25 CCF54079.1 - 1.9e-16 60.2 0.0 7.2e-13 48.6 0.0 2.4 2 0 0 2 2 2 2 Lipase (class 3) SLX9 PF15341.6 CCF54080.1 - 1.7e-20 73.7 16.1 4.2e-20 72.5 16.1 1.7 1 1 0 1 1 1 1 Ribosome biogenesis protein SLX9 RNA_pol_3_Rpc31 PF11705.8 CCF54080.1 - 0.0001 22.6 12.1 0.0001 22.6 12.1 1.7 2 0 0 2 2 2 1 DNA-directed RNA polymerase III subunit Rpc31 CENP-B_dimeris PF09026.10 CCF54080.1 - 0.018 15.4 13.8 0.03 14.7 13.8 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain SAPS PF04499.15 CCF54080.1 - 0.068 11.9 10.9 0.078 11.8 10.9 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Sigma70_ner PF04546.13 CCF54080.1 - 0.087 12.7 12.1 0.13 12.2 12.1 1.3 1 0 0 1 1 1 0 Sigma-70, non-essential region DUF4611 PF15387.6 CCF54080.1 - 0.11 12.8 11.0 0.21 11.8 11.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) TP_methylase PF00590.20 CCF54080.1 - 0.12 12.3 0.5 0.23 11.4 0.5 1.4 1 0 0 1 1 1 0 Tetrapyrrole (Corrin/Porphyrin) Methylases GCIP PF13324.6 CCF54080.1 - 0.16 11.6 9.5 0.23 11.0 9.5 1.4 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting CDC27 PF09507.10 CCF54080.1 - 0.45 9.8 19.7 0.67 9.3 19.7 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Afi1 PF07792.12 CCF54080.1 - 0.79 10.2 9.2 1.6 9.2 9.2 1.6 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking DNA_pol_phi PF04931.13 CCF54080.1 - 1.5 6.8 21.9 1.9 6.5 21.9 1.1 1 0 0 1 1 1 0 DNA polymerase phi PPP4R2 PF09184.11 CCF54080.1 - 2.3 7.7 14.0 3.5 7.2 14.0 1.3 1 0 0 1 1 1 0 PPP4R2 Cwf_Cwc_15 PF04889.12 CCF54080.1 - 2.8 7.6 28.2 6 6.5 27.8 1.7 1 1 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein p450 PF00067.22 CCF54081.1 - 1.6e-55 188.7 0.0 1.9e-55 188.5 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 LPD13 PF18825.1 CCF54081.1 - 0.092 12.5 0.0 0.2 11.4 0.0 1.5 1 0 0 1 1 1 0 Large polyvalent protein-associated domain 13 Mannosyl_trans PF05007.13 CCF54082.1 - 4e-61 207.1 15.9 2.3e-57 194.8 15.1 2.4 2 0 0 2 2 2 2 Mannosyltransferase (PIG-M) UPF0061 PF02696.14 CCF54083.1 - 1.7e-96 323.8 0.0 2.4e-96 323.3 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized ACR, YdiU/UPF0061 family Androgen_recep PF02166.16 CCF54083.1 - 0.16 10.8 2.6 0.28 10.0 2.6 1.3 1 0 0 1 1 1 0 Androgen receptor Cupin_8 PF13621.6 CCF54084.1 - 6.7e-21 75.1 0.5 9.1e-21 74.7 0.5 1.1 1 0 0 1 1 1 1 Cupin-like domain JmjC PF02373.22 CCF54084.1 - 3e-15 56.6 0.1 6.2e-15 55.6 0.1 1.5 1 0 0 1 1 1 1 JmjC domain, hydroxylase GPI PF06560.11 CCF54084.1 - 0.15 11.3 0.0 0.26 10.5 0.0 1.3 1 0 0 1 1 1 0 Glucose-6-phosphate isomerase (GPI) HigB-like_toxin PF05015.13 CCF54084.1 - 0.17 12.3 0.3 2.3 8.7 0.0 2.8 3 1 0 3 3 3 0 RelE-like toxin of type II toxin-antitoxin system HigB Peptidase_C48 PF02902.19 CCF54085.1 - 5.4e-36 124.5 0.1 8.3e-33 114.0 0.0 2.6 2 0 0 2 2 2 2 Ulp1 protease family, C-terminal catalytic domain SGT1 PF07093.11 CCF54086.1 - 4.9e-75 253.1 25.6 3.9e-57 194.0 0.1 3.4 3 1 0 3 3 3 2 SGT1 protein PG_binding_2 PF08823.11 CCF54086.1 - 0.093 13.1 0.0 0.093 13.1 0.0 2.4 3 0 0 3 3 3 0 Putative peptidoglycan binding domain LCE PF14672.6 CCF54086.1 - 1.4 9.6 6.7 0.19 12.3 0.3 2.8 3 0 0 3 3 3 0 Late cornified envelope DIL PF01843.19 CCF54087.1 - 1.7e-29 102.2 0.9 1.7e-29 102.2 0.9 2.2 3 0 0 3 3 3 1 DIL domain Ank_4 PF13637.6 CCF54087.1 - 3.1e-11 43.5 0.1 0.001 19.6 0.0 3.7 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 CCF54087.1 - 2.1e-10 41.1 0.0 2e-09 37.9 0.0 2.4 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 CCF54087.1 - 6.4e-08 32.3 0.7 0.0025 18.2 0.0 4.0 4 0 0 4 4 4 2 Ankyrin repeat Ank PF00023.30 CCF54087.1 - 3.1e-06 27.4 0.1 0.004 17.5 0.0 3.8 3 0 0 3 3 3 1 Ankyrin repeat Ank_5 PF13857.6 CCF54087.1 - 0.011 16.1 0.0 1.1 9.7 0.0 3.2 2 1 1 3 3 3 0 Ankyrin repeats (many copies) eIF-3c_N PF05470.12 CCF54087.1 - 0.075 11.3 5.8 0.12 10.7 5.8 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus Astro_capsid_p PF12226.8 CCF54087.1 - 1.3 8.1 6.6 2.2 7.3 6.6 1.3 1 0 0 1 1 1 0 Turkey astrovirus capsid protein DUF4746 PF15928.5 CCF54087.1 - 4 6.8 6.6 6.7 6.0 6.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Spo7 PF03907.13 CCF54088.1 - 6.9 6.1 10.1 0.25 10.8 3.8 1.8 2 1 1 3 3 3 0 Spo7-like protein MIT PF04212.18 CCF54089.1 - 5.5e-08 32.8 0.1 1.1e-07 31.8 0.1 1.5 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain SUR7 PF06687.12 CCF54090.1 - 4.7e-26 91.7 0.4 5.7e-26 91.5 0.4 1.1 1 0 0 1 1 1 1 SUR7/PalI family Claudin_2 PF13903.6 CCF54090.1 - 1.7e-06 27.9 1.1 4.1e-06 26.7 0.1 1.9 1 1 1 2 2 2 1 PMP-22/EMP/MP20/Claudin tight junction PMP22_Claudin PF00822.20 CCF54090.1 - 0.0086 16.0 0.7 0.0086 16.0 0.7 2.0 3 0 0 3 3 3 1 PMP-22/EMP/MP20/Claudin family SH3BGR PF04908.15 CCF54090.1 - 0.21 11.8 0.0 0.47 10.6 0.0 1.5 2 0 0 2 2 2 0 SH3-binding, glutamic acid-rich protein Yip1 PF04893.17 CCF54090.1 - 1.7 8.3 13.9 0.35 10.6 10.1 1.7 2 0 0 2 2 2 0 Yip1 domain CorA PF01544.18 CCF54091.1 - 5.6e-44 150.6 0.1 8.4e-44 150.0 0.1 1.2 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein Baculo_PEP_C PF04513.12 CCF54091.1 - 0.091 12.8 0.2 0.2 11.7 0.2 1.5 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus MOSC PF03473.17 CCF54092.1 - 4.2e-22 78.6 0.0 6.6e-22 77.9 0.0 1.3 1 0 0 1 1 1 1 MOSC domain MOSC_N PF03476.16 CCF54092.1 - 2.3e-18 66.2 0.0 1.4e-17 63.7 0.0 2.3 2 1 0 2 2 2 1 MOSC N-terminal beta barrel domain AMP-binding PF00501.28 CCF54093.1 - 6.1e-80 268.9 0.0 1.3e-79 267.8 0.0 1.5 2 0 0 2 2 2 1 AMP-binding enzyme AMP-binding_C PF13193.6 CCF54093.1 - 1.3e-18 67.8 0.3 3.5e-18 66.3 0.3 1.8 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain ADH_zinc_N PF00107.26 CCF54093.1 - 2.3e-15 56.7 0.4 2.3e-15 56.7 0.4 2.6 3 0 0 3 3 3 1 Zinc-binding dehydrogenase ACAS_N PF16177.5 CCF54093.1 - 9.6e-13 47.8 0.4 2.8e-12 46.4 0.4 1.8 1 0 0 1 1 1 1 Acetyl-coenzyme A synthetase N-terminus ADH_N PF08240.12 CCF54093.1 - 0.0036 17.2 0.4 0.16 11.9 0.0 3.7 3 1 0 3 3 3 1 Alcohol dehydrogenase GroES-like domain SDH_alpha PF03313.15 CCF54093.1 - 0.31 10.7 3.2 0.69 9.5 3.2 1.5 1 0 0 1 1 1 0 Serine dehydratase alpha chain Nop PF01798.18 CCF54094.1 - 1.1e-72 244.3 0.0 1.7e-72 243.6 0.0 1.3 1 0 0 1 1 1 1 snoRNA binding domain, fibrillarin Prp31_C PF09785.9 CCF54094.1 - 1.1e-38 132.9 4.1 1.1e-38 132.9 4.1 2.0 2 0 0 2 2 2 1 Prp31 C terminal domain Ada3 PF10198.9 CCF54095.1 - 0.032 14.4 2.6 0.05 13.7 2.0 1.5 1 1 1 2 2 2 0 Histone acetyltransferases subunit 3 MCM PF00493.23 CCF54096.1 - 3.1e-104 347.0 0.6 4.5e-104 346.4 0.6 1.2 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 CCF54096.1 - 2.6e-40 137.2 0.8 4.6e-40 136.4 0.8 1.4 1 0 0 1 1 1 1 MCM OB domain MCM6_C PF18263.1 CCF54096.1 - 2.4e-30 104.9 0.3 5.3e-30 103.8 0.3 1.6 1 0 0 1 1 1 1 MCM6 C-terminal winged-helix domain MCM_lid PF17855.1 CCF54096.1 - 6.9e-26 90.5 0.9 1.6e-25 89.3 0.4 1.9 2 0 0 2 2 2 1 MCM AAA-lid domain MCM_N PF14551.6 CCF54096.1 - 3.6e-21 75.7 0.1 1.3e-20 74.0 0.1 2.0 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 CCF54096.1 - 1e-07 31.5 0.0 4.3e-07 29.5 0.0 1.9 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 CCF54096.1 - 0.00096 19.0 0.0 0.0021 17.9 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 CCF54096.1 - 0.0021 17.8 0.0 0.0044 16.7 0.0 1.5 1 0 0 1 1 1 1 Sigma-54 interaction domain Succ_DH_flav_C PF02910.20 CCF54096.1 - 0.018 15.0 0.0 0.048 13.6 0.0 1.7 1 0 0 1 1 1 0 Fumarate reductase flavoprotein C-term AAA_5 PF07728.14 CCF54096.1 - 0.021 14.8 0.0 0.06 13.3 0.0 1.9 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Tir_receptor_M PF03549.14 CCF54096.1 - 0.029 14.7 0.0 0.12 12.7 0.0 2.0 1 0 0 1 1 1 0 Translocated intimin receptor (Tir) intimin-binding domain SOGA PF11365.8 CCF54096.1 - 0.26 12.4 1.9 7.6 7.7 0.1 2.5 2 0 0 2 2 2 0 Protein SOGA Ceramidase_alk PF04734.13 CCF54097.1 - 1.9e-178 594.3 0.0 5.4e-178 592.7 0.0 1.6 1 1 0 1 1 1 1 Neutral/alkaline non-lysosomal ceramidase, N-terminal Ceramidse_alk_C PF17048.5 CCF54097.1 - 7.5e-43 146.3 0.6 6.3e-41 140.0 0.6 2.4 1 1 0 1 1 1 1 Neutral/alkaline non-lysosomal ceramidase, C-terminal ATP-grasp_2 PF08442.10 CCF54098.1 - 2.3e-71 239.5 1.3 2.7e-71 239.3 0.5 1.5 2 0 0 2 2 2 1 ATP-grasp domain Ligase_CoA PF00549.19 CCF54098.1 - 7.3e-22 77.8 0.9 1.6e-21 76.7 0.5 1.8 2 0 0 2 2 2 1 CoA-ligase ATP-grasp_5 PF13549.6 CCF54098.1 - 4.8e-10 39.3 0.8 8.4e-10 38.5 0.2 1.7 2 0 0 2 2 2 1 ATP-grasp domain GARS_A PF01071.19 CCF54098.1 - 0.00022 21.1 0.4 0.00063 19.6 0.1 2.1 2 1 0 2 2 2 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain ATP-grasp PF02222.22 CCF54098.1 - 0.0051 16.4 0.2 0.013 15.1 0.0 1.9 2 0 0 2 2 2 1 ATP-grasp domain Nif11 PF07862.11 CCF54098.1 - 0.047 14.0 0.0 24 5.3 0.0 3.7 3 0 0 3 3 3 0 Nif11 domain PASTA PF03793.19 CCF54098.1 - 0.22 11.4 0.5 0.84 9.5 0.1 2.2 2 0 0 2 2 2 0 PASTA domain Rrp15p PF07890.12 CCF54099.1 - 4.8e-33 114.3 3.9 4.8e-33 114.3 3.9 2.6 1 1 1 2 2 2 1 Rrp15p LZ_Tnp_IS66 PF13007.7 CCF54099.1 - 0.044 14.6 3.3 0.044 14.6 3.3 3.8 3 2 1 4 4 4 0 Transposase C of IS166 homeodomain PI3K_1B_p101 PF10486.9 CCF54099.1 - 0.67 7.7 7.2 0.18 9.6 2.4 1.9 2 0 0 2 2 2 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit CENP-B_dimeris PF09026.10 CCF54099.1 - 4.9 7.6 10.0 8.2 6.9 3.6 2.5 2 0 0 2 2 2 0 Centromere protein B dimerisation domain PLDc PF00614.22 CCF54100.1 - 1.2e-15 56.9 0.1 6.6e-07 29.3 0.0 2.6 2 0 0 2 2 2 2 Phospholipase D Active site motif PLDc_2 PF13091.6 CCF54100.1 - 3.4e-13 49.6 0.0 1.7e-07 31.2 0.0 2.9 2 0 0 2 2 2 2 PLD-like domain PX PF00787.24 CCF54100.1 - 7.5e-10 38.8 0.0 1.9e-09 37.5 0.0 1.7 1 0 0 1 1 1 1 PX domain DUF3484 PF11983.8 CCF54100.1 - 0.41 11.8 3.8 0.54 11.4 0.4 3.3 2 0 0 2 2 2 0 Membrane-attachment and polymerisation-promoting switch UQ_con PF00179.26 CCF54101.1 - 4.9e-39 133.2 0.0 5.3e-39 133.1 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 CCF54101.1 - 0.00029 21.1 0.1 0.00034 20.9 0.1 1.2 1 0 0 1 1 1 1 RWD domain UFC1 PF08694.11 CCF54101.1 - 0.027 14.1 0.0 0.044 13.4 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin-fold modifier-conjugating enzyme 1 Bac_rhodopsin PF01036.18 CCF54102.1 - 3.8e-44 150.9 15.2 5e-44 150.5 15.2 1.0 1 0 0 1 1 1 1 Bacteriorhodopsin-like protein ResIII PF04851.15 CCF54102.1 - 0.098 12.6 0.3 0.17 11.9 0.3 1.3 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit Arteri_Gl PF00951.18 CCF54102.1 - 1.3 8.8 7.7 0.11 12.3 1.5 2.0 1 1 1 2 2 2 0 Arterivirus GL envelope glycoprotein E1-E2_ATPase PF00122.20 CCF54103.1 - 5.3e-22 78.2 0.0 1.4e-21 76.8 0.0 1.8 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.26 CCF54103.1 - 5.8e-16 59.4 0.0 1.3e-08 35.3 0.0 2.8 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 CCF54103.1 - 0.014 15.1 0.1 0.037 13.7 0.1 1.7 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 CCF54103.1 - 0.02 15.0 0.0 0.043 13.9 0.0 1.5 1 0 0 1 1 1 0 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 CCF54103.1 - 0.043 13.5 0.0 0.09 12.5 0.0 1.5 1 0 0 1 1 1 0 Cation transporter/ATPase, N-terminus S6PP PF05116.13 CCF54103.1 - 0.13 11.8 0.0 1.5 8.2 0.0 2.5 3 0 0 3 3 3 0 Sucrose-6F-phosphate phosphohydrolase DASH_Dad4 PF08650.10 CCF54104.1 - 3e-25 88.0 3.9 3.5e-25 87.8 3.9 1.0 1 0 0 1 1 1 1 DASH complex subunit Dad4 MFS_1 PF07690.16 CCF54105.1 - 1e-31 110.2 21.7 1e-31 110.2 21.7 1.3 2 0 0 2 2 2 1 Major Facilitator Superfamily MFS_1_like PF12832.7 CCF54105.1 - 4.1e-05 22.6 11.0 0.00017 20.5 11.0 1.7 1 1 0 1 1 1 1 MFS_1 like family DUF962 PF06127.11 CCF54105.1 - 0.08 13.0 0.3 1.6 8.8 0.3 2.8 1 1 0 1 1 1 0 Protein of unknown function (DUF962) OATP PF03137.20 CCF54105.1 - 0.43 8.8 12.0 0.46 8.7 0.4 2.8 2 1 1 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family EXS PF03124.14 CCF54105.1 - 0.8 9.0 9.0 0.24 10.7 4.2 2.4 1 1 0 2 2 2 0 EXS family Raffinose_syn PF05691.12 CCF54106.1 - 5.8e-27 93.8 0.7 7.6e-24 83.5 0.4 2.3 1 1 1 2 2 2 2 Raffinose synthase or seed imbibition protein Sip1 UCH PF00443.29 CCF54107.1 - 2.1e-52 178.2 0.0 3.2e-52 177.6 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 CCF54107.1 - 1.6e-29 103.5 0.2 4.1e-22 79.2 0.0 2.6 3 0 0 3 3 3 2 Ubiquitin carboxyl-terminal hydrolase Peptidase_C98 PF15499.6 CCF54107.1 - 0.13 11.7 2.9 0.18 11.3 1.0 2.0 3 0 0 3 3 3 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase TruB_C PF09142.11 CCF54107.1 - 0.39 10.5 2.0 0.91 9.4 0.1 2.6 3 0 0 3 3 3 0 tRNA Pseudouridine synthase II, C terminal Zn_clus PF00172.18 CCF54109.1 - 1.8e-06 28.0 13.6 4.1e-06 26.8 13.6 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 CCF54109.1 - 0.0024 17.0 1.2 0.0044 16.1 0.1 1.9 2 0 0 2 2 2 1 Fungal specific transcription factor domain RVT_1 PF00078.27 CCF54111.1 - 0.0071 15.9 0.1 0.011 15.3 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) LtrA PF06772.11 CCF54112.1 - 3.1e-31 108.9 22.5 4.2e-31 108.5 22.5 1.1 1 0 0 1 1 1 1 Bacterial low temperature requirement A protein (LtrA) DUF1211 PF06736.11 CCF54112.1 - 0.61 10.6 4.4 0.98 9.9 1.8 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1211) TraL PF07178.11 CCF54113.1 - 1.1 9.8 4.4 3.2 8.3 0.8 3.4 3 0 0 3 3 3 0 TraL protein eIF3_N PF09440.10 CCF54114.1 - 7.8e-45 152.6 0.3 1.7e-44 151.5 0.3 1.6 1 0 0 1 1 1 1 eIF3 subunit 6 N terminal domain PCI PF01399.27 CCF54114.1 - 1.2e-09 38.6 0.1 5.8e-09 36.4 0.0 2.1 2 0 0 2 2 2 1 PCI domain HhH-GPD PF00730.25 CCF54115.1 - 4.6e-11 43.1 0.0 1e-10 42.0 0.0 1.6 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein NAD_binding_10 PF13460.6 CCF54116.1 - 3.1e-14 53.3 0.0 4.8e-14 52.7 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 CCF54116.1 - 9.5e-14 51.5 0.0 1.3e-13 51.0 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family Epimerase PF01370.21 CCF54116.1 - 9.3e-12 44.9 0.3 6e-11 42.3 0.3 2.1 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 CCF54116.1 - 2.4e-09 36.6 0.0 1.3e-08 34.3 0.0 1.8 1 1 1 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 CCF54116.1 - 3.7e-09 36.1 0.0 7e-08 31.9 0.0 2.1 1 1 0 1 1 1 1 RmlD substrate binding domain GDP_Man_Dehyd PF16363.5 CCF54116.1 - 2.7e-06 27.0 0.1 9.2e-06 25.3 0.0 1.7 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 CCF54116.1 - 6.9e-06 25.4 0.1 0.11 11.6 0.0 3.0 1 1 2 3 3 3 2 Male sterility protein adh_short_C2 PF13561.6 CCF54116.1 - 0.00027 20.5 0.0 0.0021 17.7 0.0 2.1 2 1 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCF54116.1 - 0.00029 20.3 0.0 0.00062 19.3 0.0 1.6 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.10 CCF54116.1 - 0.0023 17.9 0.0 0.089 12.7 0.0 2.2 2 0 0 2 2 2 1 KR domain Polysacc_synt_2 PF02719.15 CCF54116.1 - 0.037 13.2 0.0 0.056 12.6 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein DapB_N PF01113.20 CCF54116.1 - 0.095 12.8 0.0 0.17 12.0 0.0 1.4 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus Ferric_reduct PF01794.19 CCF54117.1 - 3.2e-21 75.7 15.8 3.2e-21 75.7 15.8 2.1 3 0 0 3 3 3 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.12 CCF54117.1 - 3.2e-13 49.7 0.1 9.5e-13 48.2 0.0 1.8 2 0 0 2 2 2 1 FAD-binding domain NAD_binding_6 PF08030.12 CCF54117.1 - 2e-07 31.3 0.0 3.6e-05 24.0 0.0 2.3 1 1 0 1 1 1 1 Ferric reductase NAD binding domain Thg1 PF04446.12 CCF54118.1 - 1.3e-44 151.2 0.0 1.8e-44 150.7 0.0 1.2 1 0 0 1 1 1 1 tRNAHis guanylyltransferase Thg1C PF14413.6 CCF54118.1 - 4.3e-43 146.3 1.4 1.2e-42 144.9 1.4 1.7 1 1 0 1 1 1 1 Thg1 C terminal domain DUF3698 PF12479.8 CCF54118.1 - 0.14 12.8 0.0 0.26 11.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3698) RVT_2 PF07727.14 CCF54120.1 - 4.5e-24 85.4 0.0 4.9e-24 85.3 0.0 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.27 CCF54121.1 - 7.9e-06 25.5 0.0 1.2e-05 24.9 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-MYND PF01753.18 CCF54124.1 - 0.76 9.9 3.8 1.4 9.1 3.8 1.4 1 0 0 1 1 1 0 MYND finger GTP_CH_N PF12471.8 CCF54127.1 - 1.2e-88 296.0 0.0 1.8e-88 295.4 0.0 1.3 1 0 0 1 1 1 1 GTP cyclohydrolase N terminal GTP_cyclohydro2 PF00925.20 CCF54127.1 - 3.2e-13 49.6 0.0 4.8e-13 49.0 0.0 1.2 1 0 0 1 1 1 1 GTP cyclohydrolase II DUF5082 PF16888.5 CCF54127.1 - 0.06 13.6 0.8 0.092 13.0 0.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5082) PA PF02225.22 CCF54127.1 - 0.061 13.3 0.0 0.16 12.0 0.0 1.7 1 0 0 1 1 1 0 PA domain RVT_2 PF07727.14 CCF54130.1 - 6e-17 62.1 0.1 6.4e-17 62.0 0.1 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Arf PF00025.21 CCF54131.1 - 2.5e-79 264.8 0.1 2.8e-79 264.6 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 CCF54131.1 - 1.3e-14 54.4 0.0 1.8e-14 54.0 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 CCF54131.1 - 3.6e-14 52.6 0.0 4.5e-14 52.3 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 CCF54131.1 - 7.8e-13 48.3 0.0 8.3e-13 48.2 0.0 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 CCF54131.1 - 8.7e-13 48.1 1.2 5.9e-09 35.5 0.4 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.12 CCF54131.1 - 2e-10 40.4 0.0 2.5e-10 40.1 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 CCF54131.1 - 2.7e-06 27.5 0.0 4.2e-06 26.8 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.18 CCF54131.1 - 0.0067 15.8 0.4 0.021 14.1 0.1 1.7 2 0 0 2 2 2 1 6-phosphofructo-2-kinase Pox_A12 PF04651.13 CCF54133.1 - 0.69 9.9 2.9 1.8 8.6 2.9 1.7 1 0 0 1 1 1 0 Poxvirus A12 protein Dfp1_Him1_M PF08630.10 CCF54134.1 - 2.3e-35 121.6 0.0 5.7e-35 120.3 0.0 1.7 1 0 0 1 1 1 1 Dfp1/Him1, central region zf-DBF PF07535.12 CCF54134.1 - 2.3e-19 69.2 0.6 4.1e-19 68.4 0.6 1.4 1 0 0 1 1 1 1 DBF zinc finger BRCT PF00533.26 CCF54134.1 - 4.2e-05 23.8 0.2 0.00017 21.9 0.0 2.0 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 CCF54134.1 - 0.0007 19.5 0.1 0.0017 18.3 0.1 1.6 1 0 0 1 1 1 1 twin BRCT domain BRCT_2 PF16589.5 CCF54134.1 - 0.063 13.7 0.0 0.17 12.3 0.0 1.7 1 0 0 1 1 1 0 BRCT domain, a BRCA1 C-terminus domain Nbl1_Borealin_N PF10444.9 CCF54135.1 - 7.7e-16 57.5 1.5 1.3e-15 56.8 1.5 1.4 1 0 0 1 1 1 1 Nbl1 / Borealin N terminal CEP63 PF17045.5 CCF54135.1 - 0.00045 20.2 1.0 0.00045 20.2 1.0 1.5 2 0 0 2 2 2 1 Centrosomal protein of 63 kDa ECM1 PF05782.11 CCF54135.1 - 0.8 8.6 13.9 0.036 13.0 2.2 2.4 1 1 1 2 2 2 0 Extracellular matrix protein 1 (ECM1) DUF3807 PF12720.7 CCF54135.1 - 6.7 6.9 13.7 6.1 7.1 5.4 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3807) Mit_KHE1 PF10173.9 CCF54136.1 - 4.3e-59 199.8 1.1 1.3e-58 198.3 0.3 1.9 2 0 0 2 2 2 1 Mitochondrial K+-H+ exchange-related DUF952 PF06108.12 CCF54137.1 - 9.7e-16 57.6 0.0 1.3e-15 57.2 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF952) DSHCT PF08148.12 CCF54138.1 - 1.7e-49 167.7 0.4 4.2e-49 166.4 0.4 1.7 1 0 0 1 1 1 1 DSHCT (NUC185) domain Ski2_N PF17911.1 CCF54138.1 - 7.4e-37 126.2 0.2 1.9e-36 124.9 0.2 1.7 1 0 0 1 1 1 1 Ski2 N-terminal region rRNA_proc-arch PF13234.6 CCF54138.1 - 1.1e-28 100.9 0.0 2.4e-28 99.9 0.0 1.5 1 0 0 1 1 1 1 rRNA-processing arch domain DEAD PF00270.29 CCF54138.1 - 1.3e-19 70.7 0.0 2.8e-19 69.6 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 CCF54138.1 - 4.3e-07 30.1 0.1 1.1e-06 28.8 0.0 1.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 CCF54138.1 - 1e-05 25.9 0.0 3.1e-05 24.3 0.0 1.9 1 1 0 1 1 1 1 Helicase conserved C-terminal domain DUF3516 PF12029.8 CCF54138.1 - 0.061 12.4 1.0 0.09 11.8 0.4 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3516) AAA_22 PF13401.6 CCF54138.1 - 0.14 12.4 0.0 0.4 10.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain Ferritin_2 PF13668.6 CCF54140.1 - 1e-17 64.6 0.2 1.7e-17 63.9 0.2 1.3 1 0 0 1 1 1 1 Ferritin-like domain PAS_6 PF08348.11 CCF54142.1 - 0.0065 16.3 0.3 0.0085 16.0 0.3 1.3 1 0 0 1 1 1 1 YheO-like PAS domain NPA PF16469.5 CCF54142.1 - 0.018 15.6 0.5 0.028 15.0 0.5 1.4 1 1 0 1 1 1 0 Nematode polyprotein allergen ABA-1 Fib_alpha PF08702.10 CCF54142.1 - 0.057 13.6 1.1 0.08 13.1 1.1 1.2 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family Trimer_CC PF08954.11 CCF54142.1 - 0.46 10.1 2.5 0.4 10.3 0.8 1.9 2 0 0 2 2 2 0 Trimerisation motif Aldolase_II PF00596.21 CCF54143.1 - 5.8e-44 150.3 0.0 7.4e-44 149.9 0.0 1.1 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain PHD PF00628.29 CCF54144.1 - 5e-06 26.3 19.0 8.7e-06 25.5 19.0 1.4 1 0 0 1 1 1 1 PHD-finger SET PF00856.28 CCF54145.1 - 4.7e-16 59.6 0.0 4.7e-16 59.6 0.0 3.3 3 2 0 3 3 3 1 SET domain AWS PF17907.1 CCF54145.1 - 8e-13 48.2 2.7 2e-12 46.9 2.7 1.7 1 0 0 1 1 1 1 AWS domain Zn_clus PF00172.18 CCF54146.1 - 1.3e-06 28.4 10.3 2.3e-06 27.6 10.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 CCF54146.1 - 0.00025 20.2 0.0 0.0014 17.7 0.0 2.0 2 0 0 2 2 2 1 Fungal specific transcription factor domain Ldh_1_C PF02866.18 CCF54147.1 - 5.5e-48 163.1 0.1 1.1e-47 162.1 0.1 1.4 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.23 CCF54147.1 - 9.5e-45 152.2 0.1 1.3e-44 151.7 0.1 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain 3Beta_HSD PF01073.19 CCF54147.1 - 0.00015 20.8 0.0 0.00029 20.0 0.0 1.4 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family THF_DHG_CYH_C PF02882.19 CCF54147.1 - 0.0042 16.4 0.5 0.072 12.4 0.0 2.6 2 1 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Semialdhyde_dh PF01118.24 CCF54147.1 - 0.013 15.9 0.1 0.063 13.7 0.0 2.3 2 1 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain Ribosomal_L7Ae PF01248.26 CCF54148.1 - 5.5e-21 74.1 0.5 9.2e-21 73.4 0.5 1.4 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family HTH_Tnp_Tc5 PF03221.16 CCF54149.1 - 7e-14 51.6 0.1 1.4e-13 50.7 0.1 1.5 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain CENP-B_N PF04218.13 CCF54149.1 - 0.0035 17.0 0.0 0.0082 15.7 0.0 1.6 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain HTH_28 PF13518.6 CCF54149.1 - 0.019 15.1 0.0 1.1 9.5 0.0 2.6 2 0 0 2 2 2 0 Helix-turn-helix domain EthD PF07110.11 CCF54149.1 - 0.026 15.7 2.3 3.2 9.0 0.0 3.2 2 0 0 2 2 2 0 EthD domain Terminase_5 PF06056.12 CCF54149.1 - 0.14 12.1 0.1 3.9 7.4 0.1 2.3 2 0 0 2 2 2 0 Putative ATPase subunit of terminase (gpP-like) HTH_23 PF13384.6 CCF54149.1 - 0.18 11.6 0.2 3.4 7.6 0.0 2.9 3 0 0 3 3 3 0 Homeodomain-like domain CENP-R PF06729.12 CCF54150.1 - 0.077 12.9 3.6 0.33 10.9 3.6 2.1 1 0 0 1 1 1 0 Kinetochore component, CENP-R MAPEG PF01124.18 CCF54151.1 - 2.9e-13 49.9 2.3 3.4e-13 49.6 2.3 1.1 1 0 0 1 1 1 1 MAPEG family Lambda_tail_I PF06805.12 CCF54151.1 - 0.068 13.5 0.0 0.13 12.6 0.0 1.5 1 0 0 1 1 1 0 Bacteriophage lambda tail assembly protein I Iso_dh PF00180.20 CCF54152.1 - 2.1e-83 280.4 0.0 2.5e-83 280.1 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase DUF166 PF02593.14 CCF54152.1 - 0.085 12.4 0.0 0.15 11.6 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function Ribosomal_L13 PF00572.18 CCF54153.1 - 2.7e-52 176.3 0.4 3.3e-52 176.0 0.4 1.0 1 0 0 1 1 1 1 Ribosomal protein L13 Pol_alpha_B_N PF08418.10 CCF54154.1 - 0.26 11.2 4.4 0.29 11.0 4.4 1.1 1 0 0 1 1 1 0 DNA polymerase alpha subunit B N-terminal DUF1115 PF06544.12 CCF54157.1 - 7.8e-06 26.0 0.0 1.3e-05 25.3 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1115) Peptidase_M43 PF05572.13 CCF54158.1 - 2.2e-12 47.2 0.1 4.9e-12 46.0 0.1 1.5 1 0 0 1 1 1 1 Pregnancy-associated plasma protein-A Reprolysin_5 PF13688.6 CCF54158.1 - 6.9e-06 26.3 0.4 6.9e-06 26.3 0.4 2.1 2 0 0 2 2 2 1 Metallo-peptidase family M12 Reprolysin_4 PF13583.6 CCF54158.1 - 0.00016 21.4 0.3 0.00016 21.4 0.3 2.1 3 0 0 3 3 3 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_3 PF13582.6 CCF54158.1 - 0.00026 21.5 0.6 0.00026 21.5 0.6 2.3 2 1 0 2 2 2 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M10 PF00413.24 CCF54158.1 - 0.00044 20.1 0.4 0.00059 19.7 0.3 1.3 1 1 0 1 1 1 1 Matrixin DUF4953 PF16313.5 CCF54158.1 - 0.007 15.6 0.4 0.023 13.9 0.0 1.9 2 1 0 2 2 2 1 Met-zincin Reprolysin_2 PF13574.6 CCF54158.1 - 0.0099 15.8 0.1 0.019 14.9 0.1 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like ADH_N PF08240.12 CCF54159.1 - 7.8e-27 93.3 0.3 1.8e-26 92.2 0.1 1.7 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CCF54159.1 - 3e-18 66.0 3.0 5.1e-17 62.1 3.0 2.4 1 1 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 CCF54159.1 - 7.6e-09 35.4 0.1 0.0015 18.0 0.0 3.0 3 0 0 3 3 3 2 Glucose dehydrogenase C-terminus ADH_zinc_N_2 PF13602.6 CCF54159.1 - 0.00027 22.0 0.0 0.0027 18.8 0.0 2.4 1 1 0 1 1 1 1 Zinc-binding dehydrogenase PrmA PF06325.13 CCF54159.1 - 0.034 13.5 0.8 0.054 12.9 0.8 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) AlaDh_PNT_C PF01262.21 CCF54159.1 - 0.36 10.1 3.2 0.2 10.9 1.2 1.6 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain Peptidase_C48 PF02902.19 CCF54160.1 - 6.3e-29 101.4 1.8 4.5e-21 75.7 1.0 3.3 2 1 0 2 2 2 2 Ulp1 protease family, C-terminal catalytic domain KH_2 PF07650.17 CCF54160.1 - 0.0034 17.2 0.0 0.0076 16.0 0.0 1.5 1 0 0 1 1 1 1 KH domain Aldo_ket_red PF00248.21 CCF54161.1 - 1.3e-48 165.7 0.0 1.4e-46 159.1 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family DUF3320 PF11784.8 CCF54161.1 - 0.098 12.6 0.0 0.22 11.5 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3320) DUF1752 PF08550.10 CCF54162.1 - 2.1e-12 46.6 3.0 4.5e-12 45.6 3.0 1.6 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) DUF3295 PF11702.8 CCF54162.1 - 7.3e-09 35.5 19.5 7.3e-09 35.5 19.5 6.6 2 2 3 5 5 5 1 Protein of unknown function (DUF3295) HD_3 PF13023.6 CCF54163.1 - 5.7e-42 143.5 0.2 1.4e-41 142.2 0.2 1.6 1 0 0 1 1 1 1 HD domain HD_2 PF12917.7 CCF54163.1 - 1.1e-06 28.5 0.1 1.1e-06 28.5 0.1 1.6 2 0 0 2 2 2 1 HD containing hydrolase-like enzyme DUF463 PF04317.12 CCF54163.1 - 0.011 14.7 1.0 0.018 14.0 1.0 1.2 1 0 0 1 1 1 0 YcjX-like family, DUF463 Methyltransf_28 PF02636.17 CCF54164.1 - 2e-37 129.2 0.0 3.8e-37 128.4 0.0 1.4 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_12 PF08242.12 CCF54164.1 - 0.0053 17.5 0.0 0.015 16.1 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain RrnaAD PF00398.20 CCF54164.1 - 0.0089 15.1 0.0 0.021 13.9 0.0 1.6 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase TIMELESS PF04821.14 CCF54164.1 - 0.06 12.6 0.8 0.098 11.9 0.8 1.3 1 0 0 1 1 1 0 Timeless protein SSP160 PF06933.11 CCF54164.1 - 0.7 8.0 9.4 1.3 7.1 9.4 1.3 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Sporozoite_P67 PF05642.11 CCF54164.1 - 1.8 6.6 14.4 0.033 12.3 4.0 2.2 2 0 0 2 2 2 0 Sporozoite P67 surface antigen DUF3439 PF11921.8 CCF54164.1 - 9.5 6.2 13.9 1.1e+02 2.7 15.7 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) HECT PF00632.25 CCF54165.1 - 3.3e-91 306.0 0.0 5.8e-91 305.2 0.0 1.4 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Arg_repressor_C PF02863.18 CCF54165.1 - 0.12 12.2 0.0 0.28 11.1 0.0 1.6 1 0 0 1 1 1 0 Arginine repressor, C-terminal domain GST_C_3 PF14497.6 CCF54166.1 - 3.3e-20 72.1 0.2 5.6e-20 71.4 0.2 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 CCF54166.1 - 0.022 15.0 0.0 0.044 14.0 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain ADH_N PF08240.12 CCF54167.1 - 5e-26 90.7 0.6 8.6e-26 90.0 0.6 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CCF54167.1 - 4.3e-12 46.1 0.0 6.9e-12 45.5 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 CCF54167.1 - 1e-05 25.1 1.9 0.0024 17.4 1.9 2.8 1 1 0 1 1 1 1 Glucose dehydrogenase C-terminus ADH_zinc_N_2 PF13602.6 CCF54167.1 - 0.0082 17.2 0.0 0.014 16.4 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase HA2 PF04408.23 CCF54168.1 - 3.6e-15 56.2 0.0 1e-14 54.7 0.0 1.8 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 CCF54168.1 - 3.7e-12 46.4 0.0 1.7e-11 44.3 0.0 2.2 2 0 0 2 2 2 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 CCF54168.1 - 6.3e-10 39.4 0.0 1.3e-09 38.3 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 CCF54168.1 - 0.00016 21.5 0.6 0.0034 17.2 0.6 2.3 1 1 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 CCF54168.1 - 0.0025 18.1 0.2 0.021 15.1 0.1 2.3 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 CCF54168.1 - 0.0034 17.7 0.2 0.0075 16.6 0.2 1.6 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CCF54168.1 - 0.012 15.9 0.1 0.038 14.4 0.1 1.8 1 0 0 1 1 1 0 AAA ATPase domain T2SSE PF00437.20 CCF54168.1 - 0.013 14.6 0.0 0.027 13.5 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein PhoH PF02562.16 CCF54168.1 - 0.039 13.4 0.0 0.18 11.2 0.0 1.9 2 0 0 2 2 2 0 PhoH-like protein ABC_tran PF00005.27 CCF54168.1 - 0.15 12.6 0.6 0.55 10.7 0.2 2.3 2 1 0 2 2 2 0 ABC transporter AAA_30 PF13604.6 CCF54168.1 - 0.16 11.7 2.2 0.89 9.2 2.2 2.1 1 1 0 1 1 1 0 AAA domain Pkinase PF00069.25 CCF54169.1 - 1.2e-68 231.4 0.0 1.4e-68 231.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF54169.1 - 3.9e-30 105.0 0.0 5.5e-30 104.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 CCF54169.1 - 0.023 13.7 0.0 0.039 12.9 0.0 1.4 1 1 0 1 1 1 0 Haspin like kinase domain APH PF01636.23 CCF54169.1 - 0.029 14.3 0.0 0.081 12.8 0.0 1.7 1 0 0 1 1 1 0 Phosphotransferase enzyme family Phosphonate-bd PF12974.7 CCF54170.1 - 0.006 16.2 0.2 0.015 14.9 0.2 1.8 1 1 0 1 1 1 1 ABC transporter, phosphonate, periplasmic substrate-binding protein NMT1 PF09084.11 CCF54170.1 - 0.017 15.1 0.1 0.031 14.2 0.1 1.4 1 0 0 1 1 1 0 NMT1/THI5 like F-actin_cap_A PF01267.17 CCF54171.1 - 2.7e-98 328.6 1.1 3.4e-98 328.3 1.1 1.1 1 0 0 1 1 1 1 F-actin capping protein alpha subunit Hid1 PF12722.7 CCF54171.1 - 0.039 12.1 5.4 0.051 11.7 5.4 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein TetR_C_30 PF17939.1 CCF54171.1 - 0.056 13.7 0.0 0.12 12.6 0.0 1.5 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain Bac_RepA_C PF18008.1 CCF54171.1 - 0.093 13.1 1.3 1.3 9.4 0.0 2.5 2 0 0 2 2 2 0 Replication initiator protein A C-terminal domain DUF2890 PF11081.8 CCF54171.1 - 1 9.4 8.4 1.1 9.3 6.8 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF2890) rRNA_processing PF08524.11 CCF54171.1 - 1.2 9.2 9.8 2.2 8.3 9.8 1.5 1 0 0 1 1 1 0 rRNA processing Presenilin PF01080.17 CCF54171.1 - 4.2 6.0 5.2 5.7 5.6 5.2 1.2 1 0 0 1 1 1 0 Presenilin GMC_oxred_N PF00732.19 CCF54172.1 - 4.2e-48 164.2 0.0 6.8e-48 163.5 0.0 1.3 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 CCF54172.1 - 2.9e-35 121.9 0.0 4.7e-35 121.2 0.0 1.3 1 0 0 1 1 1 1 GMC oxidoreductase Pyr_redox_2 PF07992.14 CCF54172.1 - 0.00031 20.1 0.0 0.00065 19.0 0.0 1.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 CCF54172.1 - 0.00064 18.9 0.1 0.00095 18.3 0.1 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein NAD_binding_8 PF13450.6 CCF54172.1 - 0.00064 19.9 0.2 0.003 17.7 0.1 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 CCF54172.1 - 0.00086 18.5 0.9 0.083 12.0 0.4 2.5 3 0 0 3 3 3 2 FAD binding domain DAO PF01266.24 CCF54172.1 - 0.003 17.2 0.7 0.1 12.2 0.8 2.4 2 0 0 2 2 2 1 FAD dependent oxidoreductase Trp_halogenase PF04820.14 CCF54172.1 - 0.12 11.2 0.0 0.16 10.8 0.0 1.1 1 0 0 1 1 1 0 Tryptophan halogenase Thi4 PF01946.17 CCF54172.1 - 0.12 11.6 0.1 0.26 10.5 0.1 1.4 1 0 0 1 1 1 0 Thi4 family NAD_binding_9 PF13454.6 CCF54172.1 - 0.16 11.9 0.1 0.45 10.5 0.1 1.8 1 0 0 1 1 1 0 FAD-NAD(P)-binding TrkA_N PF02254.18 CCF54172.1 - 0.17 12.2 0.2 0.35 11.1 0.2 1.5 1 0 0 1 1 1 0 TrkA-N domain Calcipressin PF04847.12 CCF54173.1 - 3.3e-26 92.2 0.0 7.1e-26 91.1 0.0 1.6 1 0 0 1 1 1 1 Calcipressin Voldacs PF03517.13 CCF54173.1 - 6.6e-22 78.1 4.3 1.4e-19 70.6 0.4 3.8 3 1 0 3 3 3 2 Regulator of volume decrease after cellular swelling RRM_1 PF00076.22 CCF54173.1 - 0.047 13.5 0.0 0.13 12.1 0.0 1.7 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Ribosomal_L36e PF01158.18 CCF54174.1 - 1.9e-39 133.8 4.9 2.2e-39 133.6 4.9 1.0 1 0 0 1 1 1 1 Ribosomal protein L36e FUSC PF04632.12 CCF54175.1 - 0.23 10.0 13.9 0.41 9.1 13.9 1.4 1 0 0 1 1 1 0 Fusaric acid resistance protein family Fib_alpha PF08702.10 CCF54175.1 - 0.58 10.3 7.7 1.1 9.4 7.7 1.4 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family Lactamase_B PF00753.27 CCF54176.1 - 2.3e-17 63.7 1.8 3.3e-17 63.1 1.8 1.3 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 CCF54176.1 - 4.4e-05 23.1 0.2 6.7e-05 22.5 0.2 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Glyco_transf_20 PF00982.21 CCF54177.1 - 3.1e-187 623.0 0.0 1.1e-138 462.9 0.0 2.0 2 0 0 2 2 2 2 Glycosyltransferase family 20 Glycos_transf_1 PF00534.20 CCF54177.1 - 0.025 14.1 0.1 3.6 7.1 0.0 2.5 2 0 0 2 2 2 0 Glycosyl transferases group 1 GCV_T PF01571.21 CCF54178.1 - 7.2e-86 287.7 0.0 9.6e-86 287.3 0.0 1.2 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain GCV_T_C PF08669.11 CCF54178.1 - 1.7e-22 79.1 0.1 4.5e-22 77.8 0.1 1.8 1 0 0 1 1 1 1 Glycine cleavage T-protein C-terminal barrel domain DUF3659 PF12396.8 CCF54178.1 - 0.13 12.2 0.1 0.36 10.8 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3659) DUF5042 PF16445.5 CCF54178.1 - 0.19 10.1 0.0 0.28 9.5 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5042) Abhydrolase_1 PF00561.20 CCF54180.1 - 3.8e-35 121.8 0.2 4.8e-35 121.5 0.2 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CCF54180.1 - 3.5e-12 46.1 0.1 2.6e-11 43.3 0.1 1.9 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 CCF54180.1 - 9.8e-12 45.9 0.5 1.4e-11 45.4 0.5 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_4 PF08386.10 CCF54180.1 - 0.027 14.6 0.0 0.048 13.8 0.0 1.4 1 0 0 1 1 1 0 TAP-like protein Ndr PF03096.14 CCF54180.1 - 0.24 10.1 0.0 0.33 9.6 0.0 1.2 1 0 0 1 1 1 0 Ndr family NUFIP1 PF10453.9 CCF54181.1 - 1.2e-11 44.2 4.5 1.2e-11 44.2 4.5 2.0 2 0 0 2 2 2 1 Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1) zf-CCCH_4 PF18044.1 CCF54181.1 - 0.00018 21.2 5.7 0.00033 20.4 5.7 1.5 1 0 0 1 1 1 1 CCCH-type zinc finger Torus PF16131.5 CCF54181.1 - 0.0011 19.6 0.1 0.0011 19.6 0.1 2.1 2 0 0 2 2 2 1 Torus domain zf-CCCH PF00642.24 CCF54181.1 - 0.097 12.6 7.3 0.023 14.6 3.5 2.0 2 0 0 2 2 2 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 CCF54181.1 - 0.3 11.2 6.8 0.72 10.0 6.8 1.6 1 0 0 1 1 1 0 Zinc finger domain SNF2_N PF00176.23 CCF54182.1 - 2e-60 204.4 0.0 4.4e-60 203.2 0.0 1.6 1 0 0 1 1 1 1 SNF2 family N-terminal domain zf-C3HC4 PF00097.25 CCF54182.1 - 1.8e-05 24.5 11.8 1.8e-05 24.5 11.8 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 CCF54182.1 - 0.00012 21.8 9.4 0.00012 21.8 9.4 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 CCF54182.1 - 0.00026 20.7 6.1 0.00026 20.7 6.1 2.2 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CCF54182.1 - 0.00031 21.0 11.7 0.00031 21.0 11.7 2.2 2 0 0 2 2 2 1 Ring finger domain Helicase_C PF00271.31 CCF54182.1 - 0.00047 20.5 0.0 0.0015 18.8 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-RING_14 PF17978.1 CCF54182.1 - 0.47 10.9 1.9 1.6 9.2 1.9 1.9 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING_UBOX PF13445.6 CCF54182.1 - 2.9 8.0 17.3 0.27 11.3 11.4 2.3 2 0 0 2 2 2 0 RING-type zinc-finger zf-RING_5 PF14634.6 CCF54182.1 - 6 6.9 17.9 0.13 12.3 10.3 2.1 2 0 0 2 2 2 0 zinc-RING finger domain Ribosomal_L4 PF00573.22 CCF54183.1 - 3.6e-72 242.1 0.0 5.3e-72 241.6 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family Ribosomal_S9 PF00380.19 CCF54184.1 - 3.2e-30 105.1 0.2 3.6e-30 105.0 0.2 1.0 1 0 0 1 1 1 1 Ribosomal protein S9/S16 SPA PF08616.10 CCF54186.1 - 5.8e-07 29.5 0.0 1e-06 28.6 0.0 1.4 1 0 0 1 1 1 1 Stabilization of polarity axis Avl9 PF09794.9 CCF54186.1 - 0.0056 15.4 0.0 1.3 7.6 0.0 2.3 2 0 0 2 2 2 2 Transport protein Avl9 DENN PF02141.21 CCF54186.1 - 0.044 13.7 0.0 0.67 9.9 0.0 2.3 2 0 0 2 2 2 0 DENN (AEX-3) domain IZUMO PF15005.6 CCF54187.1 - 0.0079 16.7 1.0 0.017 15.6 1.0 1.5 1 0 0 1 1 1 1 Izumo sperm-egg fusion, Ig domain-associated Auts2 PF15336.6 CCF54187.1 - 0.056 13.6 6.4 0.96 9.5 0.0 2.5 2 0 0 2 2 2 0 Autism susceptibility gene 2 protein Ribosomal_L35p PF01632.19 CCF54188.1 - 2.5e-05 24.7 7.2 4e-05 24.0 3.6 2.6 2 1 0 2 2 2 1 Ribosomal protein L35 HCNGP PF07818.13 CCF54189.1 - 8.1e-17 61.7 0.5 3.6e-16 59.6 0.1 2.1 2 0 0 2 2 2 1 HCNGP-like protein Ntox47 PF15540.6 CCF54189.1 - 0.0019 18.5 0.0 0.0031 17.8 0.0 1.3 1 0 0 1 1 1 1 Bacterial toxin 47 PEX11 PF05648.14 CCF54190.1 - 5.8e-18 65.2 0.1 2e-16 60.2 0.1 2.1 1 1 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) PHD PF00628.29 CCF54193.1 - 2.3e-10 40.2 8.1 4.8e-10 39.2 8.1 1.6 1 0 0 1 1 1 1 PHD-finger zf-HC5HC2H PF13771.6 CCF54193.1 - 0.62 10.3 8.0 0.63 10.3 6.0 2.1 1 1 0 1 1 1 0 PHD-like zinc-binding domain DUF1773 PF08593.10 CCF54193.1 - 0.89 10.6 2.7 2.4 9.2 0.8 2.8 2 0 0 2 2 2 0 Domain of unknown function MRPL52 PF18699.1 CCF54193.1 - 0.92 9.7 5.6 2.6 8.3 5.6 1.7 1 0 0 1 1 1 0 Mitoribosomal protein mL52 Menin PF05053.13 CCF54193.1 - 7.6 4.8 8.2 18 3.5 8.2 1.6 1 0 0 1 1 1 0 Menin Cutinase PF01083.22 CCF54195.1 - 5.4e-22 78.6 1.1 6.2e-22 78.4 1.1 1.0 1 0 0 1 1 1 1 Cutinase PE-PPE PF08237.11 CCF54195.1 - 1.3e-05 24.9 0.1 1.7e-05 24.5 0.1 1.1 1 0 0 1 1 1 1 PE-PPE domain Bacteriocin_IIc PF10439.9 CCF54195.1 - 0.077 13.1 0.2 0.62 10.2 0.0 2.3 2 0 0 2 2 2 0 Bacteriocin class II with double-glycine leader peptide Glyco_hydro_3_C PF01915.22 CCF54196.1 - 1.8e-53 181.6 0.1 3.1e-53 180.8 0.1 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 CCF54196.1 - 2.3e-38 132.4 0.0 4.9e-38 131.3 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 CCF54196.1 - 2.6e-14 53.1 0.1 4.9e-14 52.2 0.1 1.5 1 0 0 1 1 1 1 Fibronectin type III-like domain DTC PF18102.1 CCF54196.1 - 0.14 12.2 0.0 0.37 10.9 0.0 1.7 1 0 0 1 1 1 0 Deltex C-terminal domain PPP4R2 PF09184.11 CCF54197.1 - 7.4e-10 38.9 0.1 7.4e-10 38.9 0.1 2.6 1 1 1 2 2 2 1 PPP4R2 ABC_tran PF00005.27 CCF54199.1 - 8.1e-50 168.9 0.0 2.9e-28 99.1 0.0 2.7 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 CCF54199.1 - 8.6e-49 166.6 23.4 1.8e-33 116.4 4.1 3.6 3 0 0 3 3 3 2 ABC transporter transmembrane region SMC_N PF02463.19 CCF54199.1 - 1.5e-10 40.9 0.8 0.037 13.5 0.0 4.3 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CCF54199.1 - 5.8e-07 29.2 0.5 0.0065 16.2 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_23 PF13476.6 CCF54199.1 - 1.4e-06 29.0 7.3 6.6e-05 23.5 0.0 3.6 3 0 0 3 3 3 1 AAA domain AAA_21 PF13304.6 CCF54199.1 - 5.7e-05 23.1 1.2 0.44 10.3 0.4 3.7 3 1 1 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_25 PF13481.6 CCF54199.1 - 7.9e-05 22.3 0.3 1.4 8.4 0.0 3.4 3 0 0 3 3 3 2 AAA domain AAA_16 PF13191.6 CCF54199.1 - 8.4e-05 23.0 0.5 0.8 10.1 0.0 3.6 3 1 0 3 3 3 2 AAA ATPase domain AAA_24 PF13479.6 CCF54199.1 - 0.00013 21.7 0.0 0.0052 16.5 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 CCF54199.1 - 0.00016 22.1 1.0 0.43 11.0 0.1 3.8 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 CCF54199.1 - 0.00018 21.8 0.5 0.6 10.4 0.3 3.2 3 0 0 3 3 2 2 AAA domain RsgA_GTPase PF03193.16 CCF54199.1 - 0.00019 21.4 0.0 0.021 14.7 0.0 2.6 2 0 0 2 2 2 1 RsgA GTPase T2SSE PF00437.20 CCF54199.1 - 0.00086 18.4 0.2 0.28 10.2 0.1 2.3 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_15 PF13175.6 CCF54199.1 - 0.0027 17.5 0.0 1 9.0 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain MMR_HSR1 PF01926.23 CCF54199.1 - 0.0089 16.1 0.4 1.9 8.6 0.0 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_7 PF12775.7 CCF54199.1 - 0.011 15.2 0.1 3 7.3 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region Zeta_toxin PF06414.12 CCF54199.1 - 0.011 15.0 0.1 3.2 7.0 0.0 2.6 2 0 0 2 2 2 0 Zeta toxin DUF87 PF01935.17 CCF54199.1 - 0.028 14.5 1.8 2 8.5 0.1 2.8 2 0 0 2 2 2 0 Helicase HerA, central domain IstB_IS21 PF01695.17 CCF54199.1 - 0.034 13.9 0.0 3.6 7.3 0.0 2.5 2 0 0 2 2 2 0 IstB-like ATP binding protein Dynamin_N PF00350.23 CCF54199.1 - 0.068 13.2 3.2 0.59 10.2 0.0 3.1 3 0 0 3 3 3 0 Dynamin family NB-ARC PF00931.22 CCF54199.1 - 0.077 12.2 0.6 4.7 6.3 0.1 2.8 2 1 0 2 2 2 0 NB-ARC domain FtsK_SpoIIIE PF01580.18 CCF54199.1 - 0.12 11.8 0.1 4.7 6.5 0.0 2.4 2 0 0 2 2 2 0 FtsK/SpoIIIE family ATPase PF06745.13 CCF54199.1 - 0.26 10.6 2.7 16 4.7 0.1 2.9 3 0 0 3 3 3 0 KaiC AAA_33 PF13671.6 CCF54199.1 - 1.9 8.7 6.0 4.1 7.6 0.1 2.9 3 0 0 3 3 2 0 AAA domain UQ_con PF00179.26 CCF54200.1 - 1.7e-13 50.4 0.0 2.4e-13 49.9 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 CCF54200.1 - 0.072 12.8 0.1 0.12 12.1 0.1 1.4 1 0 0 1 1 1 0 Prokaryotic E2 family B CTK3 PF12243.8 CCF54201.1 - 6.1e-17 61.8 0.0 1e-16 61.1 0.0 1.3 1 0 0 1 1 1 1 CTD kinase subunit gamma CTK3 CTK3_C PF12350.8 CCF54201.1 - 8.4e-17 61.1 5.0 1.7e-16 60.1 5.0 1.4 1 0 0 1 1 1 1 CTD kinase subunit gamma CTK3 C-terminus PI3Ka PF00613.20 CCF54202.1 - 6.2e-51 172.4 0.0 1.5e-50 171.2 0.0 1.6 2 0 0 2 2 2 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3_PI4_kinase PF00454.27 CCF54202.1 - 2.7e-46 158.4 0.0 7.7e-31 107.8 0.0 2.3 1 1 1 2 2 2 2 Phosphatidylinositol 3- and 4-kinase PI3K_C2 PF00792.24 CCF54202.1 - 9.7e-39 132.5 0.0 1.6e-38 131.8 0.0 1.4 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 C2 PF00168.30 CCF54202.1 - 0.033 14.5 0.0 0.07 13.4 0.0 1.5 1 0 0 1 1 1 0 C2 domain Chromo PF00385.24 CCF54203.1 - 0.012 15.5 0.1 0.025 14.5 0.1 1.6 1 0 0 1 1 1 0 Chromo (CHRromatin Organisation MOdifier) domain Cas_Cas4 PF01930.17 CCF54203.1 - 0.022 14.9 1.0 0.048 13.8 1.0 1.5 1 0 0 1 1 1 0 Domain of unknown function DUF83 PigN PF04987.14 CCF54204.1 - 7.4e-111 371.2 18.4 1.1e-110 370.7 18.4 1.2 1 0 0 1 1 1 1 Phosphatidylinositolglycan class N (PIG-N) Phosphodiest PF01663.22 CCF54204.1 - 1.3e-05 25.0 1.5 0.0031 17.2 0.1 2.9 3 0 0 3 3 3 2 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 CCF54204.1 - 0.007 15.8 0.0 0.011 15.2 0.0 1.3 1 0 0 1 1 1 1 Sulfatase TPR_MalT PF17874.1 CCF54204.1 - 0.019 14.4 0.0 0.19 11.1 0.0 2.1 2 0 0 2 2 2 0 MalT-like TPR region Mito_carr PF00153.27 CCF54205.1 - 4.4e-40 135.5 7.7 4.6e-18 64.9 0.1 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein Marek_SORF3 PF07153.11 CCF54206.1 - 0.21 10.9 0.1 0.35 10.2 0.1 1.3 1 0 0 1 1 1 0 Marek's disease-like virus SORF3 protein Fungal_trans_2 PF11951.8 CCF54207.1 - 4.9e-10 38.8 3.5 1.4e-05 24.1 0.0 2.5 2 0 0 2 2 2 2 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF54207.1 - 0.00016 21.7 9.4 0.00016 21.7 9.4 1.7 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain NAD_binding_7 PF13241.6 CCF54208.1 - 1.8e-27 95.8 0.0 3.3e-27 94.9 0.0 1.4 1 0 0 1 1 1 1 Putative NAD(P)-binding Sirohm_synth_C PF14823.6 CCF54208.1 - 3.6e-26 90.6 0.3 5.6e-26 90.0 0.3 1.3 1 0 0 1 1 1 1 Sirohaem biosynthesis protein C-terminal Sirohm_synth_M PF14824.6 CCF54208.1 - 3.6e-11 42.3 0.4 8.3e-11 41.1 0.4 1.7 1 0 0 1 1 1 1 Sirohaem biosynthesis protein central Cnd3 PF12719.7 CCF54209.1 - 1e-83 280.9 0.7 3.4e-82 275.9 0.1 2.6 2 0 0 2 2 2 1 Nuclear condensing complex subunits, C-term domain HEAT_2 PF13646.6 CCF54209.1 - 4e-14 52.8 0.7 4.6e-07 30.1 0.2 3.5 2 0 0 2 2 2 2 HEAT repeats HEAT PF02985.22 CCF54209.1 - 5.2e-11 41.8 5.5 0.18 12.1 0.1 6.0 5 0 0 5 5 5 4 HEAT repeat HEAT_EZ PF13513.6 CCF54209.1 - 3.4e-10 40.2 2.2 0.011 16.3 0.0 5.3 5 0 0 5 5 5 2 HEAT-like repeat Adaptin_N PF01602.20 CCF54209.1 - 2e-07 30.0 1.6 0.00012 20.8 0.2 2.2 2 0 0 2 2 2 2 Adaptin N terminal region Cnd1 PF12717.7 CCF54209.1 - 3.6e-07 30.4 7.2 0.015 15.4 0.4 4.3 4 1 1 5 5 5 3 non-SMC mitotic condensation complex subunit 1 RTP1_C1 PF10363.9 CCF54209.1 - 0.0063 16.7 1.9 6.8 6.9 0.0 3.7 3 0 0 3 3 3 2 Required for nuclear transport of RNA pol II C-terminus 1 DUF4042 PF13251.6 CCF54209.1 - 0.015 15.0 0.2 4.3 7.0 0.0 3.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4042) IFRD PF05004.13 CCF54209.1 - 0.018 14.2 12.1 0.046 12.8 0.1 3.5 3 1 0 3 3 2 0 Interferon-related developmental regulator (IFRD) TBCA PF02970.16 CCF54209.1 - 2.6 8.4 7.8 0.89 9.9 0.1 3.5 3 0 0 3 3 3 0 Tubulin binding cofactor A Ribosomal_60s PF00428.19 CCF54209.1 - 2.9 8.5 22.6 0.28 11.8 6.0 3.1 2 0 0 2 2 2 0 60s Acidic ribosomal protein PBP1_TM PF14812.6 CCF54209.1 - 4.4 7.7 24.2 7.5 7.0 0.1 4.2 4 0 0 4 4 4 0 Transmembrane domain of transglycosylase PBP1 at N-terminal ORC_WH_C PF18137.1 CCF54209.1 - 5.2 7.2 8.5 13 5.9 0.0 3.2 3 0 0 3 3 3 0 Origin recognition complex winged helix C-terminal RNase_PH PF01138.21 CCF54210.1 - 1.5e-24 87.0 0.0 3e-24 86.0 0.0 1.6 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 CCF54210.1 - 0.0016 18.5 0.0 0.0032 17.5 0.0 1.5 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 Pil1 PF13805.6 CCF54211.1 - 1.8e-66 224.4 0.2 3e-66 223.6 0.2 1.3 1 0 0 1 1 1 1 Eisosome component PIL1 PDT PF00800.18 CCF54211.1 - 3.4e-65 219.3 0.0 7.5e-65 218.2 0.0 1.6 1 0 0 1 1 1 1 Prephenate dehydratase Chitin_synth_1 PF01644.17 CCF54212.1 - 2.1e-79 265.2 0.0 3.1e-79 264.6 0.0 1.2 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_1N PF08407.11 CCF54212.1 - 6.1e-30 103.0 0.1 1.5e-29 101.7 0.1 1.7 1 0 0 1 1 1 1 Chitin synthase N-terminal Chitin_synth_2 PF03142.15 CCF54212.1 - 1.1e-23 83.7 8.4 3.2e-20 72.3 0.1 2.2 1 1 1 2 2 2 2 Chitin synthase Glyco_trans_2_3 PF13632.6 CCF54212.1 - 4.3e-05 23.5 8.6 0.00018 21.5 8.6 2.2 1 1 0 1 1 1 1 Glycosyl transferase family group 2 zf-CCHC PF00098.23 CCF54213.1 - 0.01 15.9 3.0 0.01 15.9 3.0 4.9 4 1 0 4 4 4 0 Zinc knuckle Arrestin_N PF00339.29 CCF54214.1 - 0.0003 20.9 0.0 0.00068 19.7 0.0 1.5 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain DUF4203 PF13886.6 CCF54215.1 - 0.00024 20.8 24.8 0.00024 20.8 24.8 2.8 2 1 1 3 3 3 1 Domain of unknown function (DUF4203) DUF3433 PF11915.8 CCF54215.1 - 0.12 12.8 11.2 1.6 9.3 2.9 3.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3433) YtpI PF14007.6 CCF54215.1 - 4.2 7.6 7.7 0.23 11.6 0.9 2.4 2 0 0 2 2 2 0 YtpI-like protein Zn_clus PF00172.18 CCF54216.1 - 2e-07 31.0 5.6 3.2e-07 30.3 5.6 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Formyl_trans_N PF00551.19 CCF54217.1 - 9.9e-30 103.6 0.0 3.9e-17 62.6 0.0 2.6 2 1 0 2 2 2 2 Formyl transferase Histone PF00125.24 CCF54218.1 - 2e-19 70.3 0.0 2.5e-19 69.9 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Histone_H2A_C PF16211.5 CCF54218.1 - 4.1e-13 48.8 0.2 9.4e-13 47.7 0.2 1.6 1 0 0 1 1 1 1 C-terminus of histone H2A CBFD_NFYB_HMF PF00808.23 CCF54218.1 - 0.017 15.4 0.0 0.024 14.9 0.0 1.2 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone NFACT-R_1 PF05670.13 CCF54219.1 - 3.3e-40 137.1 0.1 6.6e-40 136.2 0.0 1.5 2 0 0 2 2 2 1 NFACT protein RNA binding domain Presenilin PF01080.17 CCF54219.1 - 6.6 5.4 6.4 7.8 5.2 6.4 1.1 1 0 0 1 1 1 0 Presenilin Pkinase PF00069.25 CCF54220.1 - 2.2e-64 217.4 0.0 2.8e-64 217.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF54220.1 - 9.6e-40 136.5 0.0 1.3e-39 136.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCF54220.1 - 1.4e-07 31.1 0.0 2.1e-07 30.6 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 CCF54220.1 - 0.061 12.7 0.0 0.11 11.9 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 CCF54220.1 - 0.068 12.8 0.0 0.37 10.4 0.0 1.9 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 CCF54220.1 - 0.11 12.5 0.1 0.25 11.2 0.1 1.7 1 1 0 1 1 1 0 Phosphotransferase enzyme family TFIIA PF03153.13 CCF54220.1 - 2 8.4 6.3 2.5 8.0 6.3 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit MutS_V PF00488.21 CCF54221.1 - 6.9e-37 127.3 0.0 1.2e-36 126.6 0.0 1.3 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 CCF54221.1 - 5.1e-15 56.2 0.4 5.1e-15 56.2 0.4 1.9 2 1 0 2 2 2 1 MutS domain III MutS_IV PF05190.18 CCF54221.1 - 0.0035 17.6 0.0 0.014 15.7 0.0 2.0 2 0 0 2 2 2 1 MutS family domain IV AAA_29 PF13555.6 CCF54221.1 - 0.034 13.9 0.1 0.17 11.6 0.0 2.1 2 0 0 2 2 2 0 P-loop containing region of AAA domain NB-ARC PF00931.22 CCF54221.1 - 0.038 13.2 0.0 0.086 12.0 0.0 1.5 1 0 0 1 1 1 0 NB-ARC domain AAA_21 PF13304.6 CCF54221.1 - 0.12 12.2 0.0 0.24 11.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_25 PF13481.6 CCF54221.1 - 0.17 11.4 0.4 1.8 8.1 0.1 2.5 1 1 1 2 2 2 0 AAA domain Zn_clus PF00172.18 CCF54222.1 - 1.3e-08 34.8 9.2 2.1e-08 34.1 9.2 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Chitin_synth_1 PF01644.17 CCF54223.1 - 1.6e-78 262.3 0.1 2.5e-78 261.7 0.1 1.3 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_1N PF08407.11 CCF54223.1 - 7.4e-30 102.7 0.2 1.9e-29 101.4 0.1 1.8 2 0 0 2 2 2 1 Chitin synthase N-terminal Chitin_synth_2 PF03142.15 CCF54223.1 - 9.1e-21 74.1 2.2 7.4e-13 48.0 0.0 2.2 2 0 0 2 2 2 2 Chitin synthase Glyco_trans_2_3 PF13632.6 CCF54223.1 - 0.0085 16.0 12.9 0.09 12.7 12.9 2.5 1 1 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 CCF54223.1 - 0.038 13.9 0.0 0.081 12.8 0.0 1.5 1 0 0 1 1 1 0 Glycosyltransferase like family 2 TMEM173 PF15009.6 CCF54223.1 - 0.12 11.6 1.6 0.21 10.7 1.6 1.3 1 0 0 1 1 1 0 Transmembrane protein 173 ANAPC4_WD40 PF12894.7 CCF54224.1 - 0.0015 18.8 0.0 43 4.5 0.0 4.6 4 0 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.6 CCF54224.1 - 0.03 13.9 10.0 1.2 8.7 0.1 4.9 5 0 0 5 5 5 0 PQQ-like domain Abhydrolase_1 PF00561.20 CCF54225.1 - 1.2e-17 64.4 0.3 3.8e-15 56.2 0.1 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CCF54225.1 - 4.2e-17 63.5 6.3 5.9e-17 63.0 6.3 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CCF54225.1 - 5.7e-13 48.7 0.0 1.3e-12 47.5 0.0 1.7 1 1 0 1 1 1 1 Serine aminopeptidase, S33 DUF1100 PF06500.11 CCF54225.1 - 0.001 18.0 0.0 0.0014 17.5 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1100) Abhydrolase_5 PF12695.7 CCF54225.1 - 0.1 12.4 0.0 0.34 10.7 0.0 1.9 2 1 0 2 2 2 0 Alpha/beta hydrolase family ATP-synt_Z PF16594.5 CCF54225.1 - 1.3 8.6 4.4 0.33 10.5 0.5 1.9 2 0 0 2 2 2 0 Putative AtpZ or ATP-synthase-associated MFS_1 PF07690.16 CCF54226.1 - 9.4e-30 103.7 45.4 9.4e-30 103.7 45.4 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF54226.1 - 7e-09 35.1 31.9 3.7e-05 22.8 13.0 2.3 2 1 0 2 2 2 2 Sugar (and other) transporter DUF3382 PF11862.8 CCF54226.1 - 0.057 13.7 6.9 0.91 9.8 0.6 3.6 2 1 1 3 3 3 0 Domain of unknown function (DUF3382) F-box-like PF12937.7 CCF54227.1 - 6.2e-06 26.0 0.9 6.2e-06 26.0 0.9 2.1 2 0 0 2 2 2 1 F-box-like Peptidase_S24 PF00717.23 CCF54230.1 - 1.1e-08 34.9 0.1 2.6e-08 33.7 0.1 1.6 1 1 1 2 2 2 1 Peptidase S24-like Rad60-SLD PF11976.8 CCF54231.1 - 9.1e-10 38.2 0.1 1.9e-09 37.2 0.1 1.5 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 CCF54231.1 - 0.033 13.9 0.0 0.063 13.0 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin family Synaphin PF05835.12 CCF54231.1 - 0.43 10.9 7.0 7.9 6.8 0.2 2.6 2 0 0 2 2 2 0 Synaphin protein GPS2_interact PF15784.5 CCF54231.1 - 1.3 9.5 8.0 4.4 7.8 8.0 1.9 1 0 0 1 1 1 0 G-protein pathway suppressor 2-interacting domain bZIP_1 PF00170.21 CCF54232.1 - 0.00026 21.0 3.0 0.00026 21.0 3.0 2.2 2 0 0 2 2 2 1 bZIP transcription factor HeH PF12949.7 CCF54232.1 - 0.0095 15.6 0.2 0.019 14.7 0.2 1.5 1 0 0 1 1 1 1 HeH/LEM domain SIKE PF05769.11 CCF54232.1 - 0.04 13.9 3.9 0.87 9.5 0.3 2.2 2 0 0 2 2 2 0 SIKE family Pox_Ag35 PF03286.14 CCF54232.1 - 0.082 12.7 0.2 0.19 11.5 0.2 1.6 1 0 0 1 1 1 0 Pox virus Ag35 surface protein ZapB PF06005.12 CCF54232.1 - 0.096 13.1 3.8 5.1 7.6 0.2 2.5 2 0 0 2 2 2 0 Cell division protein ZapB Serglycin PF04360.12 CCF54232.1 - 0.12 12.3 1.8 0.27 11.2 1.8 1.6 1 0 0 1 1 1 0 Serglycin AATF-Che1 PF13339.6 CCF54232.1 - 1.3 9.7 4.6 9.3 6.9 0.8 2.6 1 1 1 2 2 2 0 Apoptosis antagonizing transcription factor bZIP_2 PF07716.15 CCF54232.1 - 3.9 7.6 12.6 0.53 10.4 2.0 2.3 2 0 0 2 2 2 0 Basic region leucine zipper RasGAP_C PF03836.15 CCF54232.1 - 4.5 7.4 5.6 34 4.6 0.9 2.5 3 0 0 3 3 3 0 RasGAP C-terminus DUF5473 PF17567.2 CCF54232.1 - 5.3 7.4 9.4 0.93 9.8 1.4 2.9 3 0 0 3 3 3 0 Family of unknown function (DUF5473) PX PF00787.24 CCF54233.1 - 4.5e-17 62.0 0.2 1.5e-16 60.4 0.0 1.9 2 0 0 2 2 2 1 PX domain Homeobox_KN PF05920.11 CCF54234.1 - 3.4e-19 68.5 0.2 2.3e-18 65.8 0.0 2.4 2 0 0 2 2 2 1 Homeobox KN domain Homeodomain PF00046.29 CCF54234.1 - 1.5e-05 24.7 0.0 3.2e-05 23.7 0.0 1.5 1 0 0 1 1 1 1 Homeodomain ATG16 PF08614.11 CCF54235.1 - 0.0019 18.4 5.4 0.0019 18.4 5.4 5.5 3 1 1 4 4 4 1 Autophagy protein 16 (ATG16) Baculo_PEP_C PF04513.12 CCF54235.1 - 1.1 9.3 9.6 0.21 11.6 2.6 3.0 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus PGM_PMM_I PF02878.16 CCF54236.1 - 1.9e-38 131.3 0.2 2.8e-38 130.7 0.2 1.3 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_III PF02880.16 CCF54236.1 - 2.4e-27 95.4 0.0 4.4e-27 94.5 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.16 CCF54236.1 - 2.1e-16 60.4 0.0 5e-16 59.2 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.20 CCF54236.1 - 2.6e-07 30.7 0.0 6.1e-07 29.5 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain tRNA_int_endo PF01974.17 CCF54237.1 - 1.7e-12 47.3 0.0 3.7e-12 46.1 0.0 1.5 1 0 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain Pkinase PF00069.25 CCF54238.1 - 2.4e-71 240.2 0.0 3e-71 239.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF54238.1 - 1.4e-31 109.8 0.0 1.9e-31 109.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.24 CCF54238.1 - 8.5e-16 58.4 1.8 2.6e-15 56.9 1.8 1.9 1 0 0 1 1 1 1 Protein kinase C terminal domain Haspin_kinase PF12330.8 CCF54238.1 - 3.9e-06 26.1 0.0 5.6e-06 25.5 0.0 1.1 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 CCF54238.1 - 0.0072 15.7 0.0 0.018 14.4 0.0 1.6 2 0 0 2 2 2 1 Kinase-like FTA2 PF13095.6 CCF54238.1 - 0.022 14.4 0.0 0.74 9.4 0.0 2.2 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 TFIIB PF00382.19 CCF54239.1 - 5.7e-31 106.4 0.6 5.4e-17 61.6 0.1 3.4 2 1 0 2 2 2 2 Transcription factor TFIIB repeat BRF1 PF07741.13 CCF54239.1 - 1.4e-29 102.4 4.3 1.4e-29 102.4 4.3 4.1 3 2 0 3 3 3 1 Brf1-like TBP-binding domain TF_Zn_Ribbon PF08271.12 CCF54239.1 - 4.4e-10 38.9 0.6 4.4e-10 38.9 0.6 2.1 2 0 0 2 2 2 1 TFIIB zinc-binding Cyclin_N PF00134.23 CCF54239.1 - 0.00038 20.2 0.1 0.49 10.2 0.0 2.4 2 0 0 2 2 2 2 Cyclin, N-terminal domain Subtilosin_A PF11420.8 CCF54239.1 - 0.13 12.3 0.1 0.13 12.3 0.1 1.8 2 0 0 2 2 2 0 Bacteriocin subtilosin A FSH1 PF03959.13 CCF54240.1 - 0.17 11.5 0.0 2.2 7.9 0.0 2.0 2 0 0 2 2 2 0 Serine hydrolase (FSH1) Mob1_phocein PF03637.17 CCF54241.1 - 6.6e-20 71.8 0.1 1e-19 71.2 0.1 1.2 1 0 0 1 1 1 1 Mob1/phocein family Nop14 PF04147.12 CCF54241.1 - 5.1 5.2 11.2 7.3 4.7 11.2 1.1 1 0 0 1 1 1 0 Nop14-like family Zn_clus PF00172.18 CCF54242.1 - 2e-06 27.8 12.0 4.4e-06 26.7 12.0 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SH3_2 PF07653.17 CCF54243.1 - 9.2e-07 28.5 0.0 3.1e-06 26.8 0.0 2.0 2 0 0 2 2 2 1 Variant SH3 domain SH3_9 PF14604.6 CCF54243.1 - 2.4e-05 24.1 0.0 8.5e-05 22.3 0.0 2.0 1 0 0 1 1 1 1 Variant SH3 domain Tankyrase_bdg_C PF15327.6 CCF54243.1 - 0.00093 19.7 8.4 0.00093 19.7 8.4 3.4 3 0 0 3 3 3 1 Tankyrase binding protein C terminal domain SH3_1 PF00018.28 CCF54243.1 - 0.006 16.2 0.0 4.1 7.1 0.0 2.8 2 0 0 2 2 2 2 SH3 domain CsbD PF05532.12 CCF54244.1 - 5.1e-18 64.7 19.5 2.3e-10 40.2 5.8 2.0 1 1 1 2 2 2 2 CsbD-like HSP9_HSP12 PF04119.12 CCF54244.1 - 0.0073 16.7 0.9 0.013 15.9 0.3 1.8 1 1 0 1 1 1 1 Heat shock protein 9/12 cobW PF02492.19 CCF54245.1 - 9.7e-49 165.3 4.9 2.5e-36 124.9 1.1 2.4 1 1 1 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain HIT PF01230.23 CCF54245.1 - 2.6e-23 82.6 0.1 1.2e-22 80.5 0.0 2.2 2 0 0 2 2 2 1 HIT domain CobW_C PF07683.14 CCF54245.1 - 8.3e-19 67.3 0.5 4.3e-14 52.2 0.1 2.7 2 0 0 2 2 2 2 Cobalamin synthesis protein cobW C-terminal domain DcpS_C PF11969.8 CCF54245.1 - 0.00061 20.2 0.0 0.0015 19.0 0.0 1.6 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding MobB PF03205.14 CCF54245.1 - 0.00087 19.2 0.2 0.0028 17.6 0.1 1.9 1 1 1 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B MeaB PF03308.16 CCF54245.1 - 0.0026 16.8 0.1 0.047 12.7 0.0 2.4 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB RsgA_GTPase PF03193.16 CCF54245.1 - 0.0046 16.9 0.1 2.2 8.2 0.0 2.7 2 0 0 2 2 2 2 RsgA GTPase TsaE PF02367.17 CCF54245.1 - 0.01 15.8 0.0 0.025 14.6 0.0 1.7 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE GTP_EFTU PF00009.27 CCF54245.1 - 0.013 15.0 2.0 1.6 8.2 0.0 2.9 3 0 0 3 3 3 0 Elongation factor Tu GTP binding domain AAA_16 PF13191.6 CCF54245.1 - 0.015 15.7 1.6 0.13 12.6 0.2 3.1 3 1 0 3 3 3 0 AAA ATPase domain CDC45 PF02724.14 CCF54245.1 - 0.017 13.4 3.1 0.043 12.1 3.1 1.6 1 0 0 1 1 1 0 CDC45-like protein Sulfotransfer_4 PF17784.1 CCF54245.1 - 0.051 13.4 0.3 0.2 11.4 0.0 2.0 2 0 0 2 2 2 0 Sulfotransferase domain ATPase PF06745.13 CCF54245.1 - 0.13 11.6 0.1 5.3 6.3 0.1 2.5 2 0 0 2 2 2 0 KaiC CRAL_TRIO PF00650.20 CCF54246.1 - 2e-33 115.4 0.0 3.5e-33 114.6 0.0 1.4 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 CCF54246.1 - 3.7e-10 39.8 0.4 1.3e-09 38.0 0.4 2.0 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.6 CCF54246.1 - 3e-07 30.7 0.0 6.6e-07 29.6 0.0 1.5 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain SNARE PF05739.19 CCF54246.1 - 0.19 11.7 0.0 0.63 10.1 0.0 1.9 1 0 0 1 1 1 0 SNARE domain Cupin_8 PF13621.6 CCF54247.1 - 1.3e-62 211.8 0.0 1.8e-62 211.4 0.0 1.1 1 0 0 1 1 1 1 Cupin-like domain JmjC PF02373.22 CCF54247.1 - 0.062 13.7 0.1 0.21 12.0 0.0 1.9 2 1 0 2 2 2 0 JmjC domain, hydroxylase Ribosomal_L30 PF00327.20 CCF54249.1 - 0.061 13.2 0.1 0.12 12.2 0.1 1.5 1 0 0 1 1 1 0 Ribosomal protein L30p/L7e Dsh_C PF12316.8 CCF54249.1 - 0.068 13.6 0.0 0.096 13.1 0.0 1.2 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal FHA PF00498.26 CCF54251.1 - 1.4e-07 31.7 0.0 3.8e-07 30.3 0.0 1.8 1 1 0 1 1 1 1 FHA domain TFIID-18kDa PF02269.16 CCF54252.1 - 9.3e-14 51.2 0.0 8.2e-08 32.2 0.0 2.2 2 0 0 2 2 2 2 Transcription initiation factor IID, 18kD subunit RPAP1_C PF08620.10 CCF54253.1 - 1.9e-25 88.7 0.2 5.2e-25 87.3 0.2 1.8 1 0 0 1 1 1 1 RPAP1-like, C-terminal RPAP1_N PF08621.10 CCF54253.1 - 1.9e-08 33.9 0.1 4.9e-08 32.6 0.1 1.7 1 0 0 1 1 1 1 RPAP1-like, N-terminal HEAT PF02985.22 CCF54253.1 - 0.0031 17.6 0.8 3.5 8.2 0.0 3.2 2 0 0 2 2 2 2 HEAT repeat Gly_reductase PF09338.11 CCF54253.1 - 0.041 12.3 0.1 0.068 11.5 0.1 1.2 1 0 0 1 1 1 0 Glycine/sarcosine/betaine reductase component B subunits ETC_C1_NDUFA4 PF04800.12 CCF54254.1 - 8.7e-37 125.3 0.1 1.2e-36 124.8 0.1 1.2 1 0 0 1 1 1 1 ETC complex I subunit conserved region Proteasome PF00227.26 CCF54255.1 - 9.8e-39 132.8 0.0 1.1e-38 132.6 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit AAA PF00004.29 CCF54256.1 - 2.6e-39 134.7 0.0 4.3e-39 133.9 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 CCF54256.1 - 9e-13 47.8 0.0 2e-12 46.7 0.0 1.6 1 0 0 1 1 1 1 AAA+ lid domain RuvB_N PF05496.12 CCF54256.1 - 7.5e-07 29.0 0.0 2e-06 27.6 0.0 1.7 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 CCF54256.1 - 2.6e-06 27.9 0.1 0.00019 21.8 0.0 2.4 1 1 0 2 2 2 1 AAA ATPase domain AAA_5 PF07728.14 CCF54256.1 - 8.7e-06 25.8 0.1 5.7e-05 23.1 0.1 2.4 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 CCF54256.1 - 1.5e-05 25.2 0.1 0.0019 18.5 0.0 2.8 1 1 2 3 3 3 1 AAA domain AAA_2 PF07724.14 CCF54256.1 - 8.9e-05 22.7 0.0 0.00018 21.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_14 PF13173.6 CCF54256.1 - 0.0001 22.3 0.0 0.00019 21.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 CCF54256.1 - 0.00042 20.9 0.0 0.00087 19.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain TniB PF05621.11 CCF54256.1 - 0.0005 19.5 0.1 1.6 8.1 0.0 2.8 2 1 1 3 3 3 2 Bacterial TniB protein AAA_33 PF13671.6 CCF54256.1 - 0.00053 20.2 0.0 0.001 19.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 CCF54256.1 - 0.0006 19.2 0.2 0.0022 17.4 0.2 1.8 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_24 PF13479.6 CCF54256.1 - 0.0008 19.2 0.1 0.0014 18.4 0.1 1.5 1 1 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 CCF54256.1 - 0.0011 18.7 0.0 0.0019 17.9 0.0 1.3 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_7 PF12775.7 CCF54256.1 - 0.0017 17.9 0.0 0.0049 16.4 0.0 1.7 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_25 PF13481.6 CCF54256.1 - 0.0017 18.0 0.1 0.023 14.3 0.1 2.4 3 0 0 3 3 3 1 AAA domain RNA_helicase PF00910.22 CCF54256.1 - 0.0026 18.1 0.0 0.012 16.0 0.0 2.1 2 0 0 2 2 1 1 RNA helicase AAA_21 PF13304.6 CCF54256.1 - 0.0027 17.6 0.1 0.2 11.4 0.0 2.4 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system TIP49 PF06068.13 CCF54256.1 - 0.0033 16.7 0.0 0.0062 15.8 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain Sigma54_activat PF00158.26 CCF54256.1 - 0.0045 16.7 0.0 0.011 15.5 0.0 1.7 1 1 0 1 1 1 1 Sigma-54 interaction domain AAA_30 PF13604.6 CCF54256.1 - 0.0062 16.3 2.0 0.32 10.7 0.1 2.3 2 0 0 2 2 2 1 AAA domain AAA_28 PF13521.6 CCF54256.1 - 0.0068 16.7 0.0 0.012 15.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain Parvo_NS1 PF01057.17 CCF54256.1 - 0.009 15.1 0.0 0.014 14.5 0.0 1.2 1 0 0 1 1 1 1 Parvovirus non-structural protein NS1 Bac_DnaA PF00308.18 CCF54256.1 - 0.011 15.6 0.0 0.023 14.6 0.0 1.4 1 1 0 1 1 1 0 Bacterial dnaA protein Sigma54_activ_2 PF14532.6 CCF54256.1 - 0.013 15.6 0.0 0.025 14.7 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain CPT PF07931.12 CCF54256.1 - 0.014 15.2 0.0 0.031 14.1 0.0 1.5 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein DUF815 PF05673.13 CCF54256.1 - 0.014 14.5 0.0 0.021 14.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Guanylate_kin PF00625.21 CCF54256.1 - 0.018 14.7 0.0 0.063 13.0 0.0 1.9 3 0 0 3 3 1 0 Guanylate kinase ATPase PF06745.13 CCF54256.1 - 0.026 13.9 0.1 0.4 10.0 0.0 2.2 1 1 1 2 2 2 0 KaiC Hydin_ADK PF17213.3 CCF54256.1 - 0.027 14.7 0.2 1.4 9.2 0.0 2.4 2 0 0 2 2 2 0 Hydin Adenylate kinase-like domain NACHT PF05729.12 CCF54256.1 - 0.028 14.3 0.0 0.063 13.2 0.0 1.6 1 0 0 1 1 1 0 NACHT domain ABC_tran PF00005.27 CCF54256.1 - 0.031 14.8 0.0 0.062 13.8 0.0 1.6 1 0 0 1 1 1 0 ABC transporter AAA_17 PF13207.6 CCF54256.1 - 0.036 14.5 0.0 0.16 12.4 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_3 PF07726.11 CCF54256.1 - 0.038 13.9 0.0 0.074 12.9 0.0 1.7 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 CCF54256.1 - 0.043 13.7 0.1 0.72 9.7 0.0 2.5 2 1 0 2 2 2 0 Rad17 P-loop domain TsaE PF02367.17 CCF54256.1 - 0.048 13.7 0.0 0.087 12.8 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Zeta_toxin PF06414.12 CCF54256.1 - 0.084 12.1 0.0 0.16 11.2 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin Sec2p PF06428.11 CCF54256.1 - 0.11 12.5 0.0 0.28 11.2 0.0 1.6 1 0 0 1 1 1 0 GDP/GTP exchange factor Sec2p AAA_19 PF13245.6 CCF54256.1 - 0.13 12.5 0.8 0.81 10.0 0.1 2.2 2 1 0 2 2 2 0 AAA domain ATPase_2 PF01637.18 CCF54256.1 - 0.15 12.0 0.0 1.3 8.8 0.0 2.1 1 1 1 2 2 2 0 ATPase domain predominantly from Archaea PhoH PF02562.16 CCF54256.1 - 0.17 11.3 0.0 0.31 10.5 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein KAP_NTPase PF07693.14 CCF54256.1 - 0.18 11.0 0.5 1.3 8.2 0.1 2.1 1 1 1 2 2 2 0 KAP family P-loop domain DUF996 PF06195.13 CCF54257.1 - 0.0006 20.1 2.9 0.0006 20.1 2.9 3.9 2 1 2 4 4 4 1 Protein of unknown function (DUF996) DUF2207 PF09972.9 CCF54257.1 - 0.035 12.9 0.1 0.035 12.9 0.1 3.1 2 1 0 2 2 2 0 Predicted membrane protein (DUF2207) UPF0114 PF03350.16 CCF54257.1 - 1.9 8.7 8.5 0.041 14.1 0.8 2.2 2 0 0 2 2 2 0 Uncharacterized protein family, UPF0114 YiaAB PF05360.14 CCF54257.1 - 5.3 7.4 12.8 0.22 11.8 0.9 3.5 3 0 0 3 3 3 0 yiaA/B two helix domain ATP-synt_C PF00137.21 CCF54258.1 - 5.7e-34 116.3 35.0 7.6e-22 77.4 15.5 2.1 2 0 0 2 2 2 2 ATP synthase subunit C Med6 PF04934.14 CCF54259.1 - 1.5e-43 147.8 0.0 2e-43 147.4 0.0 1.1 1 0 0 1 1 1 1 MED6 mediator sub complex component IncD PF17628.2 CCF54260.1 - 0.12 12.1 0.0 0.2 11.4 0.0 1.3 1 0 0 1 1 1 0 Inclusion membrane protein D BRO1 PF03097.18 CCF54261.1 - 1.2e-112 376.6 0.6 1.2e-112 376.6 0.6 1.9 3 0 0 3 3 3 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.6 CCF54261.1 - 9.9e-52 176.1 9.6 1.6e-51 175.4 9.6 1.3 1 0 0 1 1 1 1 ALIX V-shaped domain binding to HIV Sec34 PF04136.15 CCF54261.1 - 0.051 13.4 1.2 0.7 9.8 0.0 2.6 1 1 1 2 2 2 0 Sec34-like family Nucleoside_tran PF01733.18 CCF54262.1 - 3.8e-29 102.1 4.3 2.4e-28 99.4 4.3 2.2 1 1 0 1 1 1 1 Nucleoside transporter Phage_holin_2_4 PF16082.5 CCF54262.1 - 0.019 14.7 3.2 0.058 13.1 1.6 2.4 2 0 0 2 2 2 0 Bacteriophage holin family, superfamily II-like Wzy_C PF04932.15 CCF54262.1 - 0.078 12.6 1.4 4.6 6.9 0.2 3.6 2 2 0 2 2 2 0 O-Antigen ligase DUF4956 PF16316.5 CCF54262.1 - 0.13 12.0 2.6 0.16 11.6 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4956) DUF3169 PF11368.8 CCF54262.1 - 0.19 11.2 1.0 0.67 9.4 0.0 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF3169) Hormone_recep PF00104.30 CCF54262.1 - 0.24 10.9 0.1 0.9 9.1 0.0 1.9 2 0 0 2 2 2 0 Ligand-binding domain of nuclear hormone receptor START PF01852.19 CCF54263.1 - 4.8e-05 22.9 0.0 0.00011 21.7 0.0 1.6 1 1 0 1 1 1 1 START domain RRM_1 PF00076.22 CCF54264.1 - 3.4e-59 196.6 0.1 4.4e-17 61.7 0.0 6.8 7 0 0 7 7 7 6 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CCF54264.1 - 2.9e-05 24.1 0.0 1 9.5 0.0 3.5 3 0 0 3 3 3 2 RNA recognition motif RRM_Rrp7 PF17799.1 CCF54264.1 - 0.0003 20.6 0.9 1 9.1 0.0 3.7 3 1 0 3 3 3 2 Rrp7 RRM-like N-terminal domain BUD22 PF09073.10 CCF54264.1 - 0.0018 17.7 16.6 0.0018 17.7 16.6 4.2 4 1 0 4 4 4 2 BUD22 Peptidase_S8 PF00082.22 CCF54265.1 - 4.4e-69 233.0 0.2 6.9e-69 232.4 0.2 1.2 1 0 0 1 1 1 1 Subtilase family TPPII PF12580.8 CCF54265.1 - 4.6e-51 173.0 0.2 9.9e-51 171.9 0.2 1.6 1 0 0 1 1 1 1 Tripeptidyl peptidase II Glycos_transf_3 PF00591.21 CCF54266.1 - 9.7e-76 254.7 0.0 6.8e-71 238.8 0.0 2.3 2 0 0 2 2 2 2 Glycosyl transferase family, a/b domain Glycos_trans_3N PF02885.17 CCF54266.1 - 0.17 11.7 0.6 0.54 10.1 0.0 2.1 2 0 0 2 2 2 0 Glycosyl transferase family, helical bundle domain Ribosomal_L12_N PF16320.5 CCF54266.1 - 7 6.4 6.6 2.1 8.1 0.3 2.6 2 0 0 2 2 2 0 Ribosomal protein L7/L12 dimerisation domain ETF PF01012.21 CCF54267.1 - 5.4e-45 153.5 0.3 7.3e-45 153.1 0.3 1.1 1 0 0 1 1 1 1 Electron transfer flavoprotein domain EF-hand_1 PF00036.32 CCF54268.1 - 3.1e-26 88.9 8.8 2.5e-08 32.9 0.0 5.2 5 0 0 5 5 5 4 EF hand EF-hand_7 PF13499.6 CCF54268.1 - 2.2e-25 88.9 7.2 4.4e-17 62.3 1.1 3.1 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 CCF54268.1 - 2.1e-22 77.1 5.3 3.9e-06 26.4 0.0 5.3 5 0 0 5 5 5 4 EF-hand domain EF-hand_5 PF13202.6 CCF54268.1 - 5.9e-13 47.7 8.2 0.00039 19.8 0.0 4.6 5 0 0 5 5 5 3 EF hand EF-hand_8 PF13833.6 CCF54268.1 - 2.5e-11 43.3 10.0 0.0066 16.3 0.8 4.2 3 2 1 4 4 4 3 EF-hand domain pair EF-hand_4 PF12763.7 CCF54268.1 - 1.8e-09 37.5 2.6 0.013 15.4 0.0 4.0 2 1 2 4 4 4 3 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 CCF54268.1 - 0.00023 21.4 1.1 0.067 13.5 0.1 3.2 2 1 1 3 3 3 2 EF-hand domain SPARC_Ca_bdg PF10591.9 CCF54268.1 - 0.0013 19.1 2.0 1.1 9.6 0.1 3.4 2 2 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region DUF1679 PF07914.11 CCF54268.1 - 0.051 12.4 0.3 0.94 8.3 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1679) EF-hand_3 PF09069.11 CCF54268.1 - 0.075 13.4 0.1 0.22 11.9 0.0 1.8 2 1 0 2 2 2 0 EF-hand Caleosin PF05042.13 CCF54268.1 - 0.23 11.4 1.9 20 5.0 0.0 3.1 2 1 0 3 3 3 0 Caleosin related protein zf-C3HC4_3 PF13920.6 CCF54269.1 - 1.5e-08 34.4 7.9 7.6e-07 28.9 3.5 2.3 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CCF54269.1 - 7.8e-07 28.9 2.9 7.8e-07 28.9 2.9 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 CCF54269.1 - 1.1e-06 28.4 8.1 2.1e-06 27.4 5.0 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CCF54269.1 - 2.5e-06 27.4 6.8 3.5e-06 26.9 4.1 2.3 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_2 PF13639.6 CCF54269.1 - 5.8e-06 26.5 9.1 1.2e-05 25.5 4.7 2.3 2 0 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.6 CCF54269.1 - 1.3e-05 25.1 3.6 1.3e-05 25.1 3.6 2.3 2 0 0 2 2 2 1 zinc-RING finger domain Prok-RING_4 PF14447.6 CCF54269.1 - 0.00021 21.1 9.1 0.0025 17.6 4.5 2.4 2 0 0 2 2 2 2 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 CCF54269.1 - 1.1 9.5 12.7 0.041 14.1 5.5 2.2 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING NOT2_3_5 PF04153.18 CCF54272.1 - 8.7e-34 116.4 2.8 8.7e-34 116.4 2.8 2.0 2 0 0 2 2 2 1 NOT2 / NOT3 / NOT5 family ArfGap PF01412.18 CCF54273.1 - 5.7e-33 113.5 0.5 1.6e-32 112.1 0.1 2.0 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf UQ_con PF00179.26 CCF54274.1 - 1.5e-42 144.6 0.0 1.9e-42 144.2 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UBA_3 PF09288.10 CCF54274.1 - 2.7e-24 84.7 0.6 4.9e-24 83.9 0.6 1.4 1 0 0 1 1 1 1 Fungal ubiquitin-associated domain UBA_6 PF18039.1 CCF54274.1 - 5.4e-05 23.0 0.1 9.2e-05 22.3 0.1 1.3 1 0 0 1 1 1 1 UBA-like domain Prok-E2_B PF14461.6 CCF54274.1 - 0.027 14.2 0.0 0.04 13.6 0.0 1.3 1 0 0 1 1 1 0 Prokaryotic E2 family B WIYLD PF10440.9 CCF54274.1 - 0.2 11.5 0.3 0.44 10.4 0.0 1.7 2 0 0 2 2 2 0 Ubiquitin-binding WIYLD domain ATP_bind_1 PF03029.17 CCF54275.1 - 1.1e-66 225.0 0.0 2.9e-56 191.0 0.0 2.7 2 1 0 2 2 2 2 Conserved hypothetical ATP binding protein AAA_33 PF13671.6 CCF54275.1 - 0.011 15.9 0.0 0.023 14.8 0.0 1.7 1 0 0 1 1 1 0 AAA domain DNA_pol_delta_4 PF04081.13 CCF54276.1 - 2.5e-26 92.6 1.1 2.9e-26 92.3 1.1 1.2 1 0 0 1 1 1 1 DNA polymerase delta, subunit 4 Synthase_beta PF11421.8 CCF54276.1 - 1.6 9.5 6.1 0.45 11.3 2.7 1.8 1 1 1 2 2 2 0 ATP synthase F1 beta subunit AbrB PF05145.12 CCF54277.1 - 0.092 11.7 5.0 0.11 11.4 5.0 1.1 1 0 0 1 1 1 0 Transition state regulatory protein AbrB DUF2207 PF09972.9 CCF54277.1 - 0.27 9.9 1.2 0.24 10.1 1.2 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF4131 PF13567.6 CCF54277.1 - 0.43 10.2 4.8 0.44 10.2 4.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) Prokineticin PF06607.11 CCF54277.1 - 0.61 10.4 1.5 1.2 9.5 1.5 1.6 1 1 0 1 1 1 0 Prokineticin SIT PF15330.6 CCF54277.1 - 1.9 8.9 4.4 2.2 8.8 4.4 1.2 1 0 0 1 1 1 0 SHP2-interacting transmembrane adaptor protein, SIT Zn_clus PF00172.18 CCF54278.1 - 1.6e-06 28.1 9.5 3.3e-06 27.1 9.5 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 CCF54278.1 - 4.7e-05 22.6 0.5 0.00034 19.7 0.5 2.1 1 1 0 1 1 1 1 Fungal specific transcription factor domain Sugar_tr PF00083.24 CCF54279.1 - 3.8e-31 108.5 24.9 8.2e-23 81.0 11.8 2.1 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 CCF54279.1 - 1.9e-27 96.1 33.3 1.9e-27 96.1 33.3 2.0 2 0 0 2 2 2 1 Major Facilitator Superfamily MFS_2 PF13347.6 CCF54279.1 - 0.00062 18.4 11.9 0.0014 17.2 11.9 1.7 1 1 0 1 1 1 1 MFS/sugar transport protein MFS_4 PF06779.14 CCF54279.1 - 0.022 14.1 15.8 0.076 12.3 15.8 1.8 1 1 0 1 1 1 0 Uncharacterised MFS-type transporter YbfB Fungal_trans PF04082.18 CCF54280.1 - 2.4e-25 89.1 0.0 4.9e-25 88.1 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF54280.1 - 1.1e-09 38.3 6.2 1.1e-09 38.3 6.2 1.9 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CUE PF02845.16 CCF54281.1 - 8.9e-13 47.7 0.0 1.6e-12 46.8 0.0 1.5 1 0 0 1 1 1 1 CUE domain Sec6 PF06046.13 CCF54281.1 - 0.014 13.8 0.0 0.034 12.5 0.0 1.6 1 1 1 2 2 2 0 Exocyst complex component Sec6 CYSTM PF12734.7 CCF54281.1 - 5.2 7.5 6.1 20 5.6 6.1 2.0 1 0 0 1 1 1 0 Cysteine-rich TM module stress tolerance WD40 PF00400.32 CCF54283.1 - 2e-17 63.2 15.2 0.00027 21.7 0.6 7.0 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF54283.1 - 4.1e-07 30.2 0.2 5.4 7.4 0.0 4.8 3 1 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Cytochrom_D1 PF02239.16 CCF54283.1 - 0.12 10.9 0.0 1.9 7.0 0.0 2.3 2 0 0 2 2 2 0 Cytochrome D1 heme domain Orai-1 PF07856.12 CCF54284.1 - 0.55 9.9 5.8 0.87 9.2 5.8 1.3 1 0 0 1 1 1 0 Mediator of CRAC channel activity UbiA PF01040.18 CCF54284.1 - 1.1 8.6 7.7 2.2 7.5 7.7 1.6 1 1 0 1 1 1 0 UbiA prenyltransferase family SR-25 PF10500.9 CCF54284.1 - 1.8 8.1 14.7 0.22 11.1 9.3 2.0 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein YtpI PF14007.6 CCF54284.1 - 3.4 7.9 6.6 0.69 10.1 0.5 2.7 2 1 1 3 3 3 0 YtpI-like protein DUF2956 PF11169.8 CCF54284.1 - 4.3 7.6 5.5 5.5 7.2 0.2 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF2956) Podoplanin PF05808.11 CCF54285.1 - 0.12 12.5 3.1 0.2 11.7 1.6 2.1 2 0 0 2 2 2 0 Podoplanin Phage_holin_2_4 PF16082.5 CCF54285.1 - 0.62 9.8 0.0 0.62 9.8 0.0 2.6 3 0 0 3 3 3 0 Bacteriophage holin family, superfamily II-like SKG6 PF08693.10 CCF54285.1 - 0.93 9.0 5.1 7.6 6.0 0.6 2.8 2 0 0 2 2 2 0 Transmembrane alpha-helix domain adh_short PF00106.25 CCF54286.1 - 1.5e-25 89.8 0.0 2e-25 89.4 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCF54286.1 - 1.5e-18 67.2 0.0 1.8e-18 67.0 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase DUF1776 PF08643.10 CCF54286.1 - 0.11 11.9 0.0 0.17 11.2 0.0 1.2 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) Bap31 PF05529.12 CCF54287.1 - 4.8e-48 162.4 7.1 7.6e-48 161.8 7.1 1.3 1 0 0 1 1 1 1 Bap31/Bap29 transmembrane region Bap31_Bap29_C PF18035.1 CCF54287.1 - 4e-08 33.1 9.4 8.2e-08 32.1 9.4 1.6 1 1 0 1 1 1 1 Bap31/Bap29 cytoplasmic coiled-coil domain DUF4446 PF14584.6 CCF54287.1 - 0.005 16.8 1.2 0.0084 16.1 0.4 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF4446) GRP PF07172.11 CCF54288.1 - 0.11 13.2 20.3 0.39 11.4 16.0 2.4 2 0 0 2 2 2 0 Glycine rich protein family SE PF08491.10 CCF54289.1 - 3.3e-98 328.1 0.0 6.4e-98 327.2 0.0 1.4 1 1 0 1 1 1 1 Squalene epoxidase FAD_binding_3 PF01494.19 CCF54289.1 - 1.5e-12 47.4 0.1 4.2e-12 46.0 0.1 1.6 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.24 CCF54289.1 - 5.7e-10 39.3 0.1 1.2e-06 28.4 0.1 2.3 2 0 0 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CCF54289.1 - 0.00012 22.2 0.4 0.00028 21.1 0.4 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 CCF54289.1 - 0.00062 19.1 0.0 0.0097 15.2 0.0 2.1 2 0 0 2 2 2 1 Thi4 family GIDA PF01134.22 CCF54289.1 - 0.0011 18.1 0.0 0.051 12.7 0.0 2.1 2 0 0 2 2 2 1 Glucose inhibited division protein A ApbA PF02558.16 CCF54289.1 - 0.0014 18.3 0.0 0.0023 17.6 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA FAD_binding_2 PF00890.24 CCF54289.1 - 0.0016 17.6 0.6 0.025 13.7 0.3 2.2 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_2 PF07992.14 CCF54289.1 - 0.0043 16.3 0.0 0.008 15.4 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CCF54289.1 - 0.016 15.8 0.1 0.074 13.6 0.1 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 CCF54289.1 - 0.023 14.0 0.2 0.036 13.4 0.2 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase 3HCDH_N PF02737.18 CCF54289.1 - 0.054 13.4 0.0 0.086 12.7 0.0 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_Gly3P_dh_N PF01210.23 CCF54289.1 - 0.057 13.4 0.0 0.11 12.5 0.0 1.4 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Lycopene_cycl PF05834.12 CCF54289.1 - 0.12 11.4 0.2 0.79 8.7 0.1 2.2 3 0 0 3 3 3 0 Lycopene cyclase protein Oxidored_molyb PF00174.19 CCF54290.1 - 9.2e-42 142.6 0.0 1.5e-41 141.8 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase molybdopterin binding domain Mo-co_dimer PF03404.16 CCF54290.1 - 1.3e-09 38.2 2.7 2.5e-06 27.6 2.3 2.4 2 0 0 2 2 2 2 Mo-co oxidoreductase dimerisation domain Bromo_TP PF07524.13 CCF54291.1 - 5.3e-11 42.4 0.1 1.1e-10 41.3 0.1 1.5 1 0 0 1 1 1 1 Bromodomain associated CBFD_NFYB_HMF PF00808.23 CCF54291.1 - 0.0017 18.6 2.3 0.0028 17.9 0.0 2.5 2 1 1 3 3 3 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Chorion_3 PF05387.11 CCF54291.1 - 0.017 14.8 0.2 0.017 14.8 0.2 2.7 3 0 0 3 3 3 0 Chorion family 3 TFIID-31kDa PF02291.15 CCF54291.1 - 0.021 14.9 0.0 0.046 13.8 0.0 1.5 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit CENP-S PF15630.6 CCF54291.1 - 0.048 14.1 0.0 0.11 12.9 0.0 1.6 1 0 0 1 1 1 0 CENP-S protein RRM_1 PF00076.22 CCF54292.1 - 1.5e-17 63.1 0.0 2.5e-17 62.4 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) End3 PF12761.7 CCF54292.1 - 0.13 12.4 1.5 0.18 12.0 1.5 1.1 1 0 0 1 1 1 0 Actin cytoskeleton-regulatory complex protein END3 Nup35_RRM_2 PF14605.6 CCF54292.1 - 0.17 11.9 0.0 0.31 11.1 0.0 1.4 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif Complex1_LYR PF05347.15 CCF54293.1 - 1.3e-10 41.2 7.0 7e-09 35.6 4.0 2.2 2 0 0 2 2 2 2 Complex 1 protein (LYR family) DUF4552 PF15089.6 CCF54293.1 - 0.3 10.1 1.8 0.37 9.8 1.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4552) tRNA_int_endo PF01974.17 CCF54294.1 - 7.3e-20 70.8 0.0 1.7e-19 69.7 0.0 1.6 1 0 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain tRNA_int_endo_N PF02778.14 CCF54294.1 - 8.2e-06 25.4 0.0 0.00046 19.8 0.0 2.4 2 0 0 2 2 2 1 tRNA intron endonuclease, N-terminal domain RisS_PPD PF16524.5 CCF54294.1 - 0.11 12.7 0.1 0.27 11.5 0.1 1.6 1 0 0 1 1 1 0 Periplasmic domain of Sensor histidine kinase RisS WD40 PF00400.32 CCF54295.1 - 5.6e-15 55.5 6.6 0.0048 17.7 0.0 6.8 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF54295.1 - 1.3e-11 44.6 0.0 2e-06 28.0 0.0 4.4 2 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 CCF54295.1 - 9.1e-05 22.3 0.4 0.077 13.0 0.2 3.7 3 0 0 3 3 3 1 WD40-like Beta Propeller Repeat eIF2A PF08662.11 CCF54295.1 - 0.0002 21.3 0.3 0.057 13.3 0.0 3.1 3 0 0 3 3 3 1 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 CCF54295.1 - 0.043 12.8 0.0 8 5.3 0.0 3.0 3 0 0 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein DUF4666 PF15697.5 CCF54295.1 - 0.098 13.4 1.4 0.21 12.3 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4666) MT-A70 PF05063.14 CCF54297.1 - 1.1e-37 129.6 0.0 2.5e-26 92.6 0.0 2.1 2 0 0 2 2 2 2 MT-A70 Iso_dh PF00180.20 CCF54298.1 - 5.8e-80 269.0 0.0 6.9e-80 268.8 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase DUF3807 PF12720.7 CCF54299.1 - 1.5 9.1 9.1 1.9 8.7 9.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) MDFI PF15316.6 CCF54299.1 - 3.4 7.7 5.4 4.5 7.3 5.4 1.2 1 0 0 1 1 1 0 MyoD family inhibitor Presenilin PF01080.17 CCF54299.1 - 10 4.8 6.6 12 4.6 6.6 1.1 1 0 0 1 1 1 0 Presenilin RTP1_C1 PF10363.9 CCF54300.1 - 4.2e-30 104.2 0.0 1.2e-29 102.7 0.0 1.9 1 0 0 1 1 1 1 Required for nuclear transport of RNA pol II C-terminus 1 RTP1_C2 PF10304.9 CCF54300.1 - 3.9e-07 29.6 0.7 3.9e-07 29.6 0.7 2.1 2 0 0 2 2 2 1 Required for nuclear transport of RNA pol II C-terminus 2 NUDIX PF00293.28 CCF54301.1 - 7.1e-11 42.3 0.0 1.2e-10 41.5 0.0 1.5 1 1 0 1 1 1 1 NUDIX domain Mod_r PF07200.13 CCF54302.1 - 2.7e-24 85.9 3.0 2.7e-24 85.9 3.0 1.8 2 0 0 2 2 2 1 Modifier of rudimentary (Mod(r)) protein Synaptobrevin PF00957.21 CCF54302.1 - 1.2 9.0 2.8 1.9 8.3 0.5 2.1 2 0 0 2 2 2 0 Synaptobrevin Acyl-CoA_dh_N PF02771.16 CCF54304.1 - 4.5e-26 91.7 0.0 7.9e-26 90.9 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_1 PF00441.24 CCF54304.1 - 5.3e-24 85.1 0.0 8.4e-24 84.5 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 CCF54304.1 - 1.9e-21 76.1 0.0 4e-21 75.0 0.0 1.6 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 CCF54304.1 - 1.2e-08 35.4 0.0 2.1e-08 34.5 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Erv26 PF04148.13 CCF54305.1 - 2.1e-14 53.8 3.4 3.6e-13 49.8 3.4 2.0 1 1 0 1 1 1 1 Transmembrane adaptor Erv26 Cyt_bd_oxida_II PF02322.15 CCF54305.1 - 2.8 7.2 9.4 3.5 6.9 8.9 1.6 1 1 1 2 2 2 0 Cytochrome bd terminal oxidase subunit II DEAD PF00270.29 CCF54306.1 - 4.2e-41 140.6 0.0 1.4e-40 138.9 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CCF54306.1 - 2.5e-24 85.8 0.0 1.3e-23 83.5 0.0 2.2 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 CCF54306.1 - 0.00015 21.8 0.0 0.00034 20.7 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 CCF54306.1 - 0.13 12.6 0.5 1.4 9.2 0.0 2.6 3 0 0 3 3 3 0 AAA domain ATP-synt_E PF05680.12 CCF54306.1 - 0.87 10.0 10.3 2.3 8.6 0.4 2.5 2 0 0 2 2 2 0 ATP synthase E chain AP3D1 PF06375.11 CCF54306.1 - 8.7 6.6 12.6 5.2 7.3 3.5 2.6 2 0 0 2 2 2 0 AP-3 complex subunit delta-1 SPRY PF00622.28 CCF54309.1 - 2.5e-06 27.6 0.0 0.0002 21.5 0.0 2.9 3 0 0 3 3 3 2 SPRY domain HOOK PF05622.12 CCF54310.1 - 0.0021 16.3 3.4 0.0035 15.6 3.4 1.2 1 0 0 1 1 1 1 HOOK protein PKcGMP_CC PF16808.5 CCF54310.1 - 1.4 8.8 4.7 0.8 9.6 0.2 2.4 2 0 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase CENP-F_leu_zip PF10473.9 CCF54310.1 - 1.5 8.8 16.3 1.5 8.8 2.8 3.0 2 1 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Csm1_N PF18504.1 CCF54310.1 - 2.7 8.4 8.7 2.8 8.3 1.2 3.0 3 0 0 3 3 3 0 Csm1 N-terminal domain DUF641 PF04859.12 CCF54310.1 - 9.7 6.5 8.2 6.5 7.1 4.9 2.3 2 1 1 3 3 3 0 Plant protein of unknown function (DUF641) MRP-L27 PF09809.9 CCF54311.1 - 1.1e-06 28.4 2.0 2.1e-05 24.3 2.0 2.6 1 1 0 1 1 1 1 Mitochondrial ribosomal protein L27 ABC_tran PF00005.27 CCF54312.1 - 7.3e-43 146.4 0.0 3.9e-21 76.0 0.0 2.9 2 0 0 2 2 2 2 ABC transporter ABC_tran_Xtn PF12848.7 CCF54312.1 - 1.5e-21 76.2 2.7 1.5e-21 76.2 2.7 2.9 4 0 0 4 4 2 1 ABC transporter AAA_21 PF13304.6 CCF54312.1 - 1.4e-15 57.9 9.1 0.0055 16.5 0.0 4.5 4 1 1 5 5 4 4 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 CCF54312.1 - 6.3e-09 36.6 12.9 0.00034 21.2 0.0 4.2 5 0 0 5 5 3 2 AAA domain AAA_15 PF13175.6 CCF54312.1 - 2.7e-08 33.9 0.1 0.028 14.1 0.1 4.1 2 2 0 3 3 3 2 AAA ATPase domain AAA_29 PF13555.6 CCF54312.1 - 5.8e-08 32.4 0.6 0.002 17.9 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 CCF54312.1 - 7.8e-08 32.4 1.0 0.0034 17.3 0.0 3.2 3 0 0 3 3 3 2 RsgA GTPase SMC_N PF02463.19 CCF54312.1 - 9.3e-08 31.8 2.6 0.23 10.8 0.1 4.1 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 CCF54312.1 - 1.8e-05 25.2 0.0 0.024 15.0 0.0 2.4 2 0 0 2 2 2 2 AAA ATPase domain MMR_HSR1 PF01926.23 CCF54312.1 - 2.4e-05 24.4 3.3 0.0025 17.9 0.1 3.8 3 1 0 3 3 3 1 50S ribosome-binding GTPase AAA_22 PF13401.6 CCF54312.1 - 6.8e-05 23.2 0.5 0.3 11.4 0.1 3.1 2 2 1 3 3 2 2 AAA domain AAA_24 PF13479.6 CCF54312.1 - 6.9e-05 22.7 0.5 0.67 9.6 0.0 3.3 3 0 0 3 3 3 2 AAA domain NACHT PF05729.12 CCF54312.1 - 0.00014 21.9 0.6 0.59 10.0 0.1 2.5 2 0 0 2 2 2 2 NACHT domain AAA_28 PF13521.6 CCF54312.1 - 0.00091 19.5 0.0 1.3 9.2 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 CCF54312.1 - 0.0014 18.4 0.2 0.38 10.4 0.2 3.2 2 1 0 2 2 2 1 AAA domain AAA PF00004.29 CCF54312.1 - 0.0021 18.5 0.0 7.3 7.0 0.0 3.8 4 0 0 4 4 3 0 ATPase family associated with various cellular activities (AAA) Dynamin_N PF00350.23 CCF54312.1 - 0.0024 18.0 5.6 0.12 12.4 0.0 4.0 2 1 1 3 3 3 1 Dynamin family FeoB_N PF02421.18 CCF54312.1 - 0.0065 16.0 0.1 0.078 12.5 0.1 2.4 2 0 0 2 2 2 1 Ferrous iron transport protein B NB-ARC PF00931.22 CCF54312.1 - 0.014 14.6 0.1 0.65 9.1 0.0 2.6 3 0 0 3 3 3 0 NB-ARC domain AAA_18 PF13238.6 CCF54312.1 - 0.014 15.9 0.1 8.8 6.9 0.0 2.9 3 0 0 3 3 2 0 AAA domain FtsK_SpoIIIE PF01580.18 CCF54312.1 - 0.017 14.5 0.1 1.9 7.8 0.0 2.4 2 0 0 2 2 2 0 FtsK/SpoIIIE family Roc PF08477.13 CCF54312.1 - 0.021 15.1 0.5 7 6.9 0.1 3.0 3 0 0 3 3 2 0 Ras of Complex, Roc, domain of DAPkinase RNA_helicase PF00910.22 CCF54312.1 - 0.029 14.7 0.4 4 7.9 0.0 3.0 3 0 0 3 3 2 0 RNA helicase AAA_25 PF13481.6 CCF54312.1 - 0.03 13.9 0.3 4.6 6.8 0.0 3.0 3 0 0 3 3 3 0 AAA domain DAP3 PF10236.9 CCF54312.1 - 0.032 13.4 1.4 6.8 5.8 0.0 3.2 3 0 0 3 3 3 0 Mitochondrial ribosomal death-associated protein 3 cobW PF02492.19 CCF54312.1 - 0.043 13.4 0.3 7.6 6.1 0.0 2.7 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Septin PF00735.18 CCF54312.1 - 0.046 13.0 0.1 4.6 6.4 0.0 2.5 2 0 0 2 2 2 0 Septin T2SSE PF00437.20 CCF54312.1 - 0.062 12.4 0.2 8.4 5.4 0.0 2.6 3 0 0 3 3 3 0 Type II/IV secretion system protein Pox_A32 PF04665.12 CCF54312.1 - 0.072 12.5 2.9 1.8 8.0 0.1 3.0 3 1 1 4 4 3 0 Poxvirus A32 protein AAA_33 PF13671.6 CCF54312.1 - 0.075 13.2 0.4 19 5.4 0.1 2.8 3 0 0 3 3 2 0 AAA domain MtrA PF04208.14 CCF54312.1 - 0.079 12.6 0.1 0.16 11.6 0.1 1.4 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, subunit A Ploopntkinase3 PF18751.1 CCF54312.1 - 0.12 12.3 0.0 4.1 7.3 0.0 2.4 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 AAA_5 PF07728.14 CCF54312.1 - 0.12 12.4 2.9 1.1 9.2 0.1 2.8 3 0 0 3 3 2 0 AAA domain (dynein-related subfamily) PhetRS_B1 PF18262.1 CCF54312.1 - 0.14 12.4 0.4 13 6.1 0.0 2.9 2 0 0 2 2 2 0 Phe-tRNA synthetase beta subunit B1 domain AAA_7 PF12775.7 CCF54312.1 - 0.24 10.9 2.7 1.9 7.9 0.0 2.9 4 0 0 4 4 3 0 P-loop containing dynein motor region DUF87 PF01935.17 CCF54312.1 - 0.4 10.7 14.9 1 9.4 0.0 4.7 4 1 1 5 5 4 0 Helicase HerA, central domain SRP54 PF00448.22 CCF54312.1 - 0.62 9.7 4.8 3.7 7.1 0.0 3.2 3 0 0 3 3 3 0 SRP54-type protein, GTPase domain NTPase_1 PF03266.15 CCF54312.1 - 1.2 9.0 6.5 1.9 8.4 0.1 3.6 4 0 0 4 4 4 0 NTPase DivIC PF04977.15 CCF54312.1 - 6.5 6.6 13.6 1.4 8.7 1.7 3.2 3 0 0 3 3 3 0 Septum formation initiator Mob1_phocein PF03637.17 CCF54313.1 - 3.5e-60 202.9 0.3 4.2e-60 202.6 0.3 1.1 1 0 0 1 1 1 1 Mob1/phocein family Asp_protease PF09668.10 CCF54314.1 - 2.8e-58 195.1 0.0 4.8e-58 194.4 0.0 1.4 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 CCF54314.1 - 5.8e-22 78.1 0.0 1.6e-21 76.6 0.0 1.8 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease ubiquitin PF00240.23 CCF54314.1 - 6.2e-13 48.3 0.0 1.2e-12 47.4 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family Asp_protease_2 PF13650.6 CCF54314.1 - 2.2e-11 44.2 0.1 6.6e-11 42.7 0.1 1.9 1 0 0 1 1 1 1 Aspartyl protease UBA_4 PF14555.6 CCF54314.1 - 0.00013 21.7 0.6 0.00053 19.8 0.2 2.3 2 0 0 2 2 2 1 UBA-like domain RVP PF00077.20 CCF54314.1 - 0.00014 22.1 0.0 0.00037 20.7 0.0 1.7 1 0 0 1 1 1 1 Retroviral aspartyl protease RVP_2 PF08284.11 CCF54314.1 - 0.0025 17.6 0.0 0.0056 16.5 0.0 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease Rad60-SLD PF11976.8 CCF54314.1 - 0.0044 16.8 0.0 0.0097 15.7 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_4 PF18036.1 CCF54314.1 - 0.1 12.7 0.0 8.6 6.5 0.0 2.4 1 1 1 2 2 2 0 Ubiquitin-like domain SMYLE_N PF18615.1 CCF54314.1 - 0.15 11.6 0.3 0.28 10.7 0.3 1.4 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain Bep_C_terminal PF17841.1 CCF54314.1 - 0.25 11.6 3.3 50 4.2 0.1 3.3 3 0 0 3 3 3 0 BID domain of Bartonella effector protein (Bep) NIF PF03031.18 CCF54315.1 - 1.7e-43 148.1 0.0 2.9e-43 147.3 0.0 1.4 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase Methyltransf_16 PF10294.9 CCF54316.1 - 1.6e-10 41.0 0.0 2.2e-10 40.5 0.0 1.2 1 0 0 1 1 1 1 Lysine methyltransferase PrmA PF06325.13 CCF54316.1 - 0.028 13.8 0.0 0.04 13.3 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Myc_N PF01056.18 CCF54316.1 - 0.17 11.8 0.0 0.31 10.9 0.0 1.4 1 1 0 1 1 1 0 Myc amino-terminal region Methyltransf_25 PF13649.6 CCF54316.1 - 0.19 12.5 0.0 0.7 10.6 0.0 1.9 1 1 0 1 1 1 0 Methyltransferase domain TMEM70 PF06979.12 CCF54317.1 - 0.017 15.5 0.1 0.029 14.8 0.1 1.3 1 0 0 1 1 1 0 Assembly, mitochondrial proton-transport ATP synth complex P21-Arc PF04062.14 CCF54318.1 - 1.4e-77 259.7 0.0 1.5e-77 259.5 0.0 1.0 1 0 0 1 1 1 1 ARP2/3 complex ARPC3 (21 kDa) subunit DNA_pol_viral_C PF00336.18 CCF54318.1 - 0.13 11.7 0.0 0.2 11.1 0.0 1.3 1 0 0 1 1 1 0 DNA polymerase (viral) C-terminal domain NOA36 PF06524.12 CCF54319.1 - 0.031 13.6 2.1 0.028 13.7 2.1 1.1 1 0 0 1 1 1 0 NOA36 protein Myb_DNA-binding PF00249.31 CCF54320.1 - 1.6e-06 28.2 0.9 0.0012 19.0 0.0 3.3 3 1 0 3 3 3 2 Myb-like DNA-binding domain ALMT PF11744.8 CCF54320.1 - 1.1 8.0 4.0 1.7 7.4 4.0 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF2151 PF10221.9 CCF54320.1 - 5.5 5.5 6.9 11 4.5 6.9 1.4 1 0 0 1 1 1 0 Cell cycle and development regulator F-box-like PF12937.7 CCF54321.1 - 4.2e-12 45.8 3.1 2e-11 43.6 3.1 2.3 1 0 0 1 1 1 1 F-box-like LRR_4 PF12799.7 CCF54321.1 - 1.4e-07 31.7 8.6 0.56 10.7 0.1 6.6 4 1 4 8 8 8 4 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 CCF54321.1 - 7.3e-06 25.6 15.9 0.53 10.5 0.1 8.5 11 0 0 11 11 11 2 Leucine Rich repeat F-box PF00646.33 CCF54321.1 - 1.6e-05 24.6 0.9 1.6e-05 24.6 0.9 3.7 4 0 0 4 4 4 1 F-box domain SAM_Ste50p PF09235.10 CCF54321.1 - 0.12 12.7 0.8 66 3.8 0.1 3.7 3 0 0 3 3 3 0 Ste50p, sterile alpha motif LRR_1 PF00560.33 CCF54321.1 - 1.8 9.4 8.9 1.5e+02 3.6 0.0 6.2 6 2 0 6 6 6 0 Leucine Rich Repeat SelP_N PF04592.14 CCF54321.1 - 1.8 7.9 9.2 3.8 6.8 9.2 1.5 1 0 0 1 1 1 0 Selenoprotein P, N terminal region CBS PF00571.28 CCF54322.1 - 6.5e-19 68.1 5.4 0.00013 22.3 0.2 5.5 5 0 0 5 5 5 4 CBS domain DUF3237 PF11578.8 CCF54324.1 - 3.6e-35 121.0 0.0 4.1e-35 120.8 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3237) ELYS PF13934.6 CCF54325.1 - 4.2e-46 157.7 0.6 5.9e-46 157.2 0.6 1.2 1 0 0 1 1 1 1 Nuclear pore complex assembly Hist_deacetyl PF00850.19 CCF54326.1 - 1.8e-79 267.4 0.0 3.1e-79 266.6 0.0 1.4 1 0 0 1 1 1 1 Histone deacetylase domain Ribosomal_60s PF00428.19 CCF54326.1 - 0.12 13.0 3.3 0.35 11.5 3.3 1.8 1 0 0 1 1 1 0 60s Acidic ribosomal protein Tub_N PF16322.5 CCF54326.1 - 0.89 9.9 4.5 1.6 9.1 0.5 2.1 2 0 0 2 2 2 0 Tubby N-terminal VEFS-Box PF09733.9 CCF54326.1 - 8.4 6.2 6.8 0.36 10.7 0.3 1.9 2 0 0 2 2 2 0 VEFS-Box of polycomb protein Coatomer_E PF04733.14 CCF54327.1 - 4.2e-42 144.5 0.8 4.9e-42 144.3 0.8 1.0 1 0 0 1 1 1 1 Coatomer epsilon subunit TPR_16 PF13432.6 CCF54327.1 - 4.3e-06 27.3 5.0 4.3e-06 27.3 5.0 3.2 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_17 PF13431.6 CCF54327.1 - 0.0014 18.9 0.2 1.3 9.6 0.1 3.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 CCF54327.1 - 0.002 18.1 2.3 0.017 15.2 0.1 3.5 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_11 PF13414.6 CCF54327.1 - 0.002 17.7 1.0 0.0041 16.8 1.0 1.6 1 0 0 1 1 1 1 TPR repeat TPR_20 PF14561.6 CCF54327.1 - 0.0054 17.0 4.5 3.6 8.0 2.0 3.5 2 2 1 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 CCF54327.1 - 0.0062 17.3 1.0 0.0062 17.3 1.0 4.6 5 1 1 6 6 5 1 Tetratricopeptide repeat TPR_1 PF00515.28 CCF54327.1 - 0.019 14.8 0.1 0.25 11.3 0.0 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.6 CCF54327.1 - 0.045 14.3 8.5 0.29 11.7 3.8 3.6 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_8 PF13181.6 CCF54327.1 - 0.11 12.8 0.0 1.1 9.6 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_4 PF07721.14 CCF54327.1 - 8.4 7.3 0.0 8.4 7.3 0.0 4.0 4 0 0 4 4 3 0 Tetratricopeptide repeat CTP_transf_like PF01467.26 CCF54328.1 - 0.0062 16.7 0.0 0.028 14.6 0.0 2.0 1 1 0 1 1 1 1 Cytidylyltransferase-like PCI PF01399.27 CCF54330.1 - 1.2e-12 48.2 0.1 4.7e-12 46.4 0.0 2.0 2 0 0 2 2 2 1 PCI domain eIF3m_C_helix PF18005.1 CCF54330.1 - 2.7e-09 36.5 1.6 2.7e-09 36.5 1.6 2.1 2 0 0 2 2 2 1 eIF3 subunit M, C-terminal helix Sybindin PF04099.12 CCF54331.1 - 8e-39 132.8 0.0 8.7e-39 132.7 0.0 1.0 1 0 0 1 1 1 1 Sybindin-like family Sedlin_N PF04628.13 CCF54331.1 - 3.4e-07 30.4 0.0 4.3e-07 30.1 0.0 1.2 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region PTH2 PF01981.16 CCF54332.1 - 1.1e-05 25.7 3.3 0.00011 22.5 3.3 2.0 1 1 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 MnmE_helical PF12631.7 CCF54333.1 - 8.5e-31 107.7 0.0 4e-30 105.5 0.0 1.8 1 1 0 1 1 1 1 MnmE helical domain TrmE_N PF10396.9 CCF54333.1 - 3.9e-28 98.1 0.0 8.1e-28 97.1 0.0 1.5 1 0 0 1 1 1 1 GTP-binding protein TrmE N-terminus MMR_HSR1 PF01926.23 CCF54333.1 - 1.7e-19 69.9 0.0 3.2e-19 69.1 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 CCF54333.1 - 2.1e-06 27.3 0.0 3.6e-06 26.6 0.0 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 CCF54333.1 - 0.00021 21.4 0.0 0.00046 20.3 0.0 1.6 1 1 0 1 1 1 1 Dynamin family AAA_24 PF13479.6 CCF54333.1 - 0.012 15.4 0.0 0.027 14.2 0.0 1.6 1 1 0 1 1 1 0 AAA domain AAA_28 PF13521.6 CCF54333.1 - 0.032 14.5 0.0 0.11 12.7 0.0 1.9 1 1 1 2 2 2 0 AAA domain AAA_25 PF13481.6 CCF54333.1 - 0.056 13.0 0.0 0.1 12.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_35 PF14516.6 CCF54333.1 - 0.074 11.9 0.0 0.12 11.1 0.0 1.3 1 0 0 1 1 1 0 AAA-like domain RsgA_GTPase PF03193.16 CCF54333.1 - 0.078 12.9 0.0 0.32 10.9 0.0 2.0 2 0 0 2 2 2 0 RsgA GTPase GTP_EFTU PF00009.27 CCF54333.1 - 0.19 11.3 0.0 20 4.6 0.0 2.4 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain FUSC_2 PF13515.6 CCF54334.1 - 1.8e-13 50.7 5.0 1.8e-13 50.7 5.0 2.6 3 1 0 3 3 3 1 Fusaric acid resistance protein-like FUSC PF04632.12 CCF54334.1 - 1.4e-12 47.0 3.6 1.4e-12 47.0 3.6 3.2 4 0 0 4 4 4 1 Fusaric acid resistance protein family ArAE_2 PF10334.9 CCF54334.1 - 9.3e-07 28.9 2.3 2.7e-06 27.4 2.3 1.8 1 0 0 1 1 1 1 Aromatic acid exporter family member 2 ALMT PF11744.8 CCF54334.1 - 1.5e-06 27.3 1.8 3.8e-06 26.0 1.8 1.6 1 0 0 1 1 1 1 Aluminium activated malate transporter ArAE_2_N PF10337.9 CCF54334.1 - 6e-06 25.6 3.7 0.00011 21.4 0.0 2.5 3 0 0 3 3 3 2 Putative ER transporter, 6TM, N-terminal ArAE_1 PF06081.11 CCF54334.1 - 0.00076 19.6 2.8 0.0025 18.0 2.8 1.9 1 0 0 1 1 1 1 Aromatic acid exporter family member 1 Snurportin1 PF11538.8 CCF54335.1 - 0.07 13.3 3.9 0.096 12.9 3.5 1.5 1 1 0 1 1 1 0 Snurportin1 ZapB PF06005.12 CCF54336.1 - 0.0032 17.9 2.2 0.0032 17.9 2.2 4.7 3 1 1 4 4 4 1 Cell division protein ZapB RPA43_OB PF17875.1 CCF54337.1 - 1.7e-19 70.6 9.5 6e-19 68.9 0.0 3.4 3 2 0 3 3 3 1 RPA43 OB domain in RNA Pol I SHS2_Rpb7-N PF03876.17 CCF54337.1 - 0.00058 20.2 0.0 0.0012 19.1 0.0 1.6 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 Ras PF00071.22 CCF54338.1 - 3.3e-50 169.9 0.0 3.9e-50 169.6 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CCF54338.1 - 2.9e-30 105.0 0.0 4.4e-30 104.4 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CCF54338.1 - 2.9e-10 39.9 0.0 3.9e-10 39.4 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 CCF54338.1 - 8.4e-05 22.0 0.0 0.0001 21.7 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 CCF54338.1 - 0.001 19.2 0.0 0.0015 18.6 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase G-alpha PF00503.20 CCF54338.1 - 0.0016 17.6 0.8 0.45 9.6 0.1 2.6 2 1 0 2 2 2 2 G-protein alpha subunit Pox_A32 PF04665.12 CCF54338.1 - 0.017 14.6 0.0 0.027 13.9 0.0 1.2 1 0 0 1 1 1 0 Poxvirus A32 protein RNA_helicase PF00910.22 CCF54338.1 - 0.017 15.5 0.1 0.14 12.5 0.1 2.1 1 1 0 1 1 1 0 RNA helicase AAA_7 PF12775.7 CCF54338.1 - 0.028 13.9 0.0 0.045 13.3 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region DUF5118 PF17162.4 CCF54338.1 - 0.037 13.8 0.1 0.071 12.9 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5118) AAA_16 PF13191.6 CCF54338.1 - 0.052 13.9 0.0 0.098 13.0 0.0 1.6 2 0 0 2 2 2 0 AAA ATPase domain RsgA_GTPase PF03193.16 CCF54338.1 - 0.053 13.4 0.0 7.2 6.5 0.0 2.2 2 0 0 2 2 2 0 RsgA GTPase AAA_24 PF13479.6 CCF54338.1 - 0.055 13.2 0.1 0.083 12.6 0.1 1.3 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 CCF54338.1 - 0.1 12.6 0.0 0.2 11.6 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_33 PF13671.6 CCF54338.1 - 0.12 12.5 0.2 0.22 11.7 0.2 1.4 1 0 0 1 1 1 0 AAA domain STAS PF01740.21 CCF54338.1 - 0.13 11.9 0.0 0.29 10.8 0.0 1.6 1 1 0 1 1 1 0 STAS domain Septin PF00735.18 CCF54338.1 - 0.13 11.5 0.0 0.21 10.8 0.0 1.4 1 0 0 1 1 1 0 Septin 14-3-3 PF00244.20 CCF54339.1 - 4.2e-108 360.0 4.2 4.8e-108 359.8 4.2 1.0 1 0 0 1 1 1 1 14-3-3 protein Orbi_VP5 PF00901.17 CCF54339.1 - 0.17 10.3 2.7 0.26 9.6 2.7 1.3 1 0 0 1 1 1 0 Orbivirus outer capsid protein VP5 HisKA PF00512.25 CCF54339.1 - 0.32 11.0 1.3 1.4 9.0 0.1 2.4 3 0 0 3 3 3 0 His Kinase A (phospho-acceptor) domain Adaptin_N PF01602.20 CCF54340.1 - 1.3e-122 410.1 12.0 1.6e-122 409.8 12.0 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptin_C PF02296.16 CCF54340.1 - 3.2e-40 136.8 0.0 7.4e-40 135.7 0.0 1.7 1 0 0 1 1 1 1 Alpha adaptin AP2, C-terminal domain Alpha_adaptinC2 PF02883.20 CCF54340.1 - 5.9e-15 55.5 0.0 1.5e-14 54.2 0.0 1.7 1 0 0 1 1 1 1 Adaptin C-terminal domain DUF1160 PF06648.11 CCF54340.1 - 0.13 12.3 0.8 0.42 10.6 0.8 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1160) zf-CCHC PF00098.23 CCF54341.1 - 3.4e-36 121.7 59.4 1.2e-07 31.5 3.4 7.2 7 0 0 7 7 7 7 Zinc knuckle zf-CCHC_4 PF14392.6 CCF54341.1 - 1.5e-07 31.0 38.3 0.025 14.3 1.1 6.9 7 0 0 7 7 7 6 Zinc knuckle zf-CCHC_3 PF13917.6 CCF54341.1 - 1.2e-05 25.2 38.3 0.028 14.4 0.3 7.0 4 2 3 7 7 7 6 Zinc knuckle Thioredoxin PF00085.20 CCF54343.1 - 1.3e-22 79.7 0.1 1.7e-22 79.4 0.1 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 CCF54343.1 - 2.6e-08 34.3 0.2 3.3e-07 30.7 0.2 2.1 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 CCF54343.1 - 4.8e-07 30.0 0.2 0.00015 22.0 0.0 2.3 1 1 1 2 2 2 2 Thioredoxin-like AhpC-TSA PF00578.21 CCF54343.1 - 0.00063 19.7 0.0 0.00081 19.3 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Thioredoxin_7 PF13899.6 CCF54343.1 - 0.0013 18.8 0.1 0.004 17.3 0.1 1.7 2 0 0 2 2 2 1 Thioredoxin-like Thioredoxin_3 PF13192.6 CCF54343.1 - 0.0063 16.5 0.1 0.011 15.8 0.1 1.4 1 0 0 1 1 1 1 Thioredoxin domain Thioredoxin_6 PF13848.6 CCF54343.1 - 0.0094 15.9 0.1 0.013 15.4 0.1 1.2 1 0 0 1 1 1 1 Thioredoxin-like domain OST3_OST6 PF04756.13 CCF54343.1 - 0.022 14.1 0.1 0.029 13.7 0.1 1.1 1 0 0 1 1 1 0 OST3 / OST6 family, transporter family HyaE PF07449.11 CCF54343.1 - 0.072 13.1 0.0 0.14 12.1 0.0 1.4 1 0 0 1 1 1 0 Hydrogenase-1 expression protein HyaE DUF836 PF05768.14 CCF54343.1 - 0.11 12.9 0.0 0.17 12.3 0.0 1.3 1 0 0 1 1 1 0 Glutaredoxin-like domain (DUF836) RRN3 PF05327.11 CCF54344.1 - 7.8e-184 612.3 0.0 7.8e-184 612.3 0.0 2.0 2 0 0 2 2 2 1 RNA polymerase I specific transcription initiation factor RRN3 GN3L_Grn1 PF08701.11 CCF54345.1 - 7e-25 86.9 20.3 7e-25 86.9 20.3 4.5 5 0 0 5 5 5 1 GNL3L/Grn1 putative GTPase TFIIF_alpha PF05793.12 CCF54345.1 - 0.00018 20.3 24.8 0.00018 20.3 24.8 3.6 3 1 0 3 3 3 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) CENP-B_dimeris PF09026.10 CCF54345.1 - 0.015 15.7 1.7 0.015 15.7 1.7 5.1 5 0 0 5 5 5 0 Centromere protein B dimerisation domain STIMATE PF12400.8 CCF54346.1 - 8e-42 142.7 1.5 1.5e-41 141.8 1.5 1.5 1 0 0 1 1 1 1 STIMATE family CAP_GLY PF01302.25 CCF54349.1 - 4.5e-15 55.4 0.1 8.8e-15 54.5 0.1 1.4 1 0 0 1 1 1 1 CAP-Gly domain LRR_4 PF12799.7 CCF54349.1 - 1.6e-12 47.4 16.9 1.6e-06 28.4 1.9 5.4 1 1 4 6 6 6 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 CCF54349.1 - 2.1e-10 40.2 17.2 2.2e-05 24.1 4.7 5.2 3 2 4 7 7 7 4 Leucine rich repeat LRR_9 PF14580.6 CCF54349.1 - 7.2e-05 22.4 2.1 0.16 11.5 0.4 2.8 2 1 1 3 3 3 2 Leucine-rich repeat LRR_6 PF13516.6 CCF54349.1 - 0.067 13.3 13.2 19 5.6 0.0 5.5 5 0 0 5 5 5 0 Leucine Rich repeat LRR_1 PF00560.33 CCF54349.1 - 0.23 12.2 10.7 59 4.8 0.0 6.1 5 1 0 5 5 5 0 Leucine Rich Repeat DPBB_1 PF03330.18 CCF54350.1 - 0.025 14.9 0.0 0.048 13.9 0.0 1.5 1 0 0 1 1 1 0 Lytic transglycolase RhoGEF PF00621.20 CCF54352.1 - 1e-23 84.5 0.1 1.7e-22 80.5 0.0 2.4 2 1 0 2 2 2 1 RhoGEF domain Peptidase_S26 PF10502.9 CCF54353.1 - 2.5e-07 30.5 0.0 0.0001 22.1 0.0 2.4 2 0 0 2 2 2 2 Signal peptidase, peptidase S26 Peptidase_S24 PF00717.23 CCF54353.1 - 5.7e-06 26.2 0.0 2.2e-05 24.3 0.0 1.9 1 1 0 1 1 1 1 Peptidase S24-like Prenyltransf PF01255.19 CCF54354.1 - 2.1e-71 240.0 0.0 2.7e-71 239.7 0.0 1.0 1 0 0 1 1 1 1 Putative undecaprenyl diphosphate synthase Ada3 PF10198.9 CCF54354.1 - 0.099 12.8 0.1 0.19 11.9 0.1 1.5 1 0 0 1 1 1 0 Histone acetyltransferases subunit 3 DUF5102 PF17104.5 CCF54355.1 - 2e-49 169.2 18.0 2e-49 169.2 18.0 3.6 1 1 2 3 3 3 1 Domain of unknown function (DUF5102) FEZ PF07763.13 CCF54355.1 - 0.0049 16.6 6.6 0.017 14.9 0.2 3.0 3 0 0 3 3 3 2 FEZ-like protein RNase_H PF00075.24 CCF54356.1 - 6.3e-05 23.2 0.0 0.00017 21.8 0.0 1.7 1 0 0 1 1 1 1 RNase H Cytochrom_C_asm PF01578.20 CCF54357.1 - 0.17 11.6 0.0 0.46 10.2 0.0 1.6 2 0 0 2 2 2 0 Cytochrome C assembly protein Acetyltransf_1 PF00583.25 CCF54358.1 - 3.1e-15 56.4 0.0 3.6e-15 56.2 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CCF54358.1 - 8.8e-11 41.8 0.1 1e-10 41.7 0.1 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CCF54358.1 - 9.6e-08 32.3 0.1 1.3e-07 32.0 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CCF54358.1 - 7.8e-06 25.8 0.1 1e-05 25.4 0.1 1.2 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.7 CCF54358.1 - 0.00033 20.7 0.0 0.00065 19.8 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_15 PF17013.5 CCF54358.1 - 0.14 11.6 0.2 0.25 10.8 0.0 1.5 2 0 0 2 2 2 0 Putative acetyl-transferase CRAL_TRIO PF00650.20 CCF54359.1 - 1.1e-36 125.9 0.2 1.9e-36 125.2 0.2 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 CCF54359.1 - 3.8e-10 39.8 0.9 8.8e-10 38.6 0.1 2.1 2 0 0 2 2 2 1 CRAL/TRIO, N-terminal domain Methyltransf_16 PF10294.9 CCF54361.1 - 3.2e-16 59.5 0.2 1.2e-11 44.7 0.1 2.2 1 1 1 2 2 2 2 Lysine methyltransferase Methyltransf_25 PF13649.6 CCF54361.1 - 0.026 15.2 0.0 0.46 11.2 0.0 2.5 1 1 0 2 2 2 0 Methyltransferase domain MTS PF05175.14 CCF54361.1 - 0.1 12.1 0.0 0.18 11.3 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain HMG_box PF00505.19 CCF54362.1 - 8.3e-22 77.4 17.5 1.5e-11 44.6 5.1 3.2 2 1 0 2 2 2 2 HMG (high mobility group) box HMG_box_2 PF09011.10 CCF54362.1 - 4.8e-18 65.5 12.7 5.8e-09 36.4 4.5 2.8 2 0 0 2 2 2 2 HMG-box domain YABBY PF04690.13 CCF54362.1 - 0.12 12.9 9.6 0.03 14.9 4.9 2.2 1 1 1 2 2 2 0 YABBY protein PP2C PF00481.21 CCF54363.1 - 8.5e-67 225.5 0.2 2.9e-51 174.6 0.1 2.1 2 0 0 2 2 2 2 Protein phosphatase 2C Pectate_lyase_3 PF12708.7 CCF54366.1 - 9.6e-92 306.7 4.6 2.5e-77 259.6 0.7 2.8 3 0 0 3 3 3 2 Pectate lyase superfamily protein End_N_terminal PF12218.8 CCF54366.1 - 3.7e-05 23.3 1.7 0.17 11.6 0.6 2.9 2 0 0 2 2 2 2 N terminal extension of bacteriophage endosialidase Beta_helix PF13229.6 CCF54366.1 - 0.18 11.7 8.0 0.024 14.5 1.5 2.8 3 1 0 3 3 3 0 Right handed beta helix region RVT_2 PF07727.14 CCF54367.1 - 5.1e-18 65.6 0.1 6.6e-18 65.2 0.1 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) 2-Hacid_dh_C PF02826.19 CCF54368.1 - 8.9e-52 175.0 0.0 1.7e-51 174.1 0.0 1.5 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 CCF54368.1 - 3.1e-15 56.0 0.0 4.8e-15 55.4 0.0 1.3 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 CCF54368.1 - 0.00011 22.4 0.2 0.00024 21.3 0.0 1.6 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase AdoHcyase_NAD PF00670.21 CCF54368.1 - 0.0045 17.1 0.0 0.023 14.8 0.0 2.1 2 0 0 2 2 2 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain F420_oxidored PF03807.17 CCF54368.1 - 0.052 14.1 0.1 0.16 12.6 0.0 1.9 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent Peptidase_M19 PF01244.21 CCF54368.1 - 0.054 12.6 0.0 0.097 11.8 0.0 1.4 1 0 0 1 1 1 0 Membrane dipeptidase (Peptidase family M19) Shikimate_DH PF01488.20 CCF54368.1 - 0.089 12.9 0.1 0.27 11.3 0.0 1.8 2 1 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase PilJ PF13675.6 CCF54368.1 - 0.11 12.5 1.7 0.26 11.3 1.7 1.6 1 0 0 1 1 1 0 Type IV pili methyl-accepting chemotaxis transducer N-term RNase_T PF00929.24 CCF54369.1 - 8.9e-18 65.4 0.0 1.2e-17 64.9 0.0 1.2 1 0 0 1 1 1 1 Exonuclease K_channel_TID PF07941.11 CCF54369.1 - 0.71 10.4 16.4 0.2 12.1 12.6 2.0 2 0 0 2 2 2 0 Potassium channel Kv1.4 tandem inactivation domain SWIB PF02201.18 CCF54370.1 - 1.3e-27 95.5 0.0 2e-27 94.9 0.0 1.3 1 0 0 1 1 1 1 SWIB/MDM2 domain DEK_C PF08766.11 CCF54370.1 - 3.3e-07 30.1 0.2 4.3e-06 26.6 0.1 2.5 2 1 0 2 2 2 1 DEK C terminal domain Vps5 PF09325.10 CCF54371.1 - 3.9e-10 39.7 3.8 5.9e-10 39.1 3.8 1.2 1 0 0 1 1 1 1 Vps5 C terminal like PX PF00787.24 CCF54371.1 - 0.014 15.4 0.0 0.038 14.0 0.0 1.8 1 0 0 1 1 1 0 PX domain Myb_DNA-binding PF00249.31 CCF54372.1 - 9.1e-13 48.2 0.5 1.7e-12 47.3 0.5 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 CCF54372.1 - 6.9e-09 35.8 0.3 1.4e-08 34.9 0.3 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain FmiP_Thoc5 PF09766.9 CCF54372.1 - 0.44 9.8 5.4 7.2 5.8 0.4 2.5 2 0 0 2 2 2 0 Fms-interacting protein/Thoc5 DHHA2 PF02833.14 CCF54373.1 - 0.087 13.0 0.2 0.25 11.5 0.0 1.8 2 0 0 2 2 2 0 DHHA2 domain Med26_M PF15694.5 CCF54373.1 - 7.2 6.6 11.8 0.99 9.4 4.4 2.1 2 0 0 2 2 2 0 Mediator complex subunit 26 middle domain Coatomer_WDAD PF04053.14 CCF54374.1 - 5.8e-153 510.1 0.0 4.2e-152 507.3 0.0 2.1 2 0 0 2 2 2 1 Coatomer WD associated region WD40 PF00400.32 CCF54374.1 - 1e-38 130.6 10.4 4.2e-08 33.7 0.0 9.0 9 0 0 9 9 9 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF54374.1 - 1e-12 48.2 0.1 0.005 17.1 0.0 6.3 5 2 2 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 CCF54374.1 - 0.098 11.3 1.4 1 7.9 0.0 3.1 2 1 2 4 4 4 0 Nucleoporin Nup120/160 EthD PF07110.11 CCF54375.1 - 0.0053 17.9 0.1 0.13 13.4 0.1 2.2 2 0 0 2 2 2 1 EthD domain Chorismate_synt PF01264.21 CCF54376.1 - 2.5e-136 453.7 0.2 3.1e-136 453.4 0.2 1.1 1 0 0 1 1 1 1 Chorismate synthase TBCC PF07986.12 CCF54377.1 - 2.1e-12 46.8 0.0 4e-12 45.9 0.0 1.4 1 0 0 1 1 1 1 Tubulin binding cofactor C Methyltransf_3 PF01596.17 CCF54378.1 - 5.2e-46 156.5 0.0 6.7e-46 156.1 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_24 PF13578.6 CCF54378.1 - 8.6e-10 39.6 0.0 1.7e-09 38.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 CCF54378.1 - 0.0011 18.7 0.0 0.0019 18.0 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) P22_CoatProtein PF11651.8 CCF54378.1 - 0.002 16.8 0.0 0.0026 16.4 0.0 1.1 1 0 0 1 1 1 1 P22 coat protein - gene protein 5 DUF2013 PF09431.10 CCF54379.1 - 3.6e-50 169.7 3.8 6e-50 169.0 3.8 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2013) RecR PF02132.15 CCF54380.1 - 0.059 13.0 5.3 0.11 12.1 5.3 1.5 1 0 0 1 1 1 0 RecR protein FA_hydroxylase PF04116.13 CCF54382.1 - 8.7e-24 84.4 11.3 8.7e-24 84.4 11.3 2.1 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily DUF3087 PF11286.8 CCF54382.1 - 0.002 17.6 0.2 0.0034 16.9 0.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3087) MBOAT PF03062.19 CCF54383.1 - 1.9e-51 175.5 6.2 1.9e-51 175.5 5.2 1.5 1 1 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family Peptidase_C14 PF00656.22 CCF54384.1 - 1.1e-57 195.9 0.1 1.4e-57 195.5 0.1 1.1 1 0 0 1 1 1 1 Caspase domain MRP-S33 PF08293.11 CCF54385.1 - 4.8e-27 94.0 0.1 5.8e-27 93.8 0.1 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal subunit S27 HSP20 PF00011.21 CCF54386.1 - 0.0013 18.8 0.0 0.0027 17.8 0.0 1.5 1 0 0 1 1 1 1 Hsp20/alpha crystallin family Pyr_redox_2 PF07992.14 CCF54387.1 - 4.1e-38 131.3 0.0 1.5e-34 119.6 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CCF54387.1 - 2.6e-09 37.5 0.0 8.8e-09 35.8 0.0 1.9 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 CCF54387.1 - 0.2 10.7 0.0 3.6 6.5 0.0 2.3 2 0 0 2 2 2 0 Lycopene cyclase protein Iron_permease PF04120.12 CCF54391.1 - 0.14 11.9 0.2 2.6 7.8 0.0 2.2 2 0 0 2 2 2 0 Low affinity iron permease RHD3 PF05879.12 CCF54392.1 - 2.4e-245 816.2 2.4 3e-245 815.9 2.4 1.1 1 0 0 1 1 1 1 Root hair defective 3 GTP-binding protein (RHD3) GBP PF02263.19 CCF54392.1 - 1.2e-06 28.0 2.1 1.2e-06 28.0 0.2 2.0 2 0 0 2 2 2 1 Guanylate-binding protein, N-terminal domain MMR_HSR1 PF01926.23 CCF54392.1 - 7.3e-06 26.0 0.2 2.3e-05 24.4 0.0 2.0 2 0 0 2 2 2 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 CCF54392.1 - 0.00014 22.0 0.0 0.00031 20.8 0.0 1.6 1 0 0 1 1 1 1 Dynamin family AAA_28 PF13521.6 CCF54392.1 - 0.0059 16.9 0.0 0.02 15.1 0.0 1.9 1 0 0 1 1 1 1 AAA domain Roc PF08477.13 CCF54392.1 - 0.071 13.3 0.7 0.22 11.7 0.0 2.1 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 CCF54392.1 - 0.077 12.6 0.0 0.22 11.1 0.0 1.7 1 0 0 1 1 1 0 Ras family Insulin_TMD PF17870.1 CCF54392.1 - 0.12 12.4 0.2 0.23 11.6 0.2 1.4 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment FeoB_N PF02421.18 CCF54392.1 - 0.15 11.6 0.0 0.27 10.7 0.0 1.4 1 0 0 1 1 1 0 Ferrous iron transport protein B NTF2 PF02136.20 CCF54393.1 - 5.1e-28 98.1 0.4 1.2e-27 96.8 0.4 1.7 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain RRM_1 PF00076.22 CCF54393.1 - 6.6e-07 29.1 0.1 1.3e-06 28.1 0.1 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4518 PF15008.6 CCF54393.1 - 5e-06 25.9 0.9 9.3e-06 25.0 0.9 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4518) RRM_occluded PF16842.5 CCF54393.1 - 0.0024 17.7 0.2 0.0054 16.6 0.2 1.5 1 0 0 1 1 1 1 Occluded RNA-recognition motif 4HBT_3 PF13622.6 CCF54394.1 - 1.7e-17 64.5 0.0 5.9e-17 62.8 0.0 1.7 1 1 0 1 1 1 1 Thioesterase-like superfamily 4HBT PF03061.22 CCF54394.1 - 0.011 16.1 0.0 0.28 11.6 0.0 2.3 2 0 0 2 2 2 0 Thioesterase superfamily SMN PF06003.12 CCF54394.1 - 0.2 10.9 0.2 0.63 9.2 0.0 1.7 2 0 0 2 2 2 0 Survival motor neuron protein (SMN) Ank_4 PF13637.6 CCF54395.1 - 7.1e-16 58.4 0.4 2.6e-08 34.2 0.1 2.4 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 CCF54395.1 - 2.1e-10 41.0 0.0 3.9e-10 40.2 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 CCF54395.1 - 1.2e-09 38.2 0.1 7.6e-08 32.5 0.0 2.5 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.30 CCF54395.1 - 1.7e-07 31.3 0.1 7.1e-05 23.1 0.0 2.6 2 0 0 2 2 2 1 Ankyrin repeat Ank_3 PF13606.6 CCF54395.1 - 2.4e-06 27.4 0.1 0.00084 19.6 0.0 2.7 2 0 0 2 2 2 1 Ankyrin repeat ProRS-C_1 PF09180.11 CCF54395.1 - 0.013 15.7 0.0 0.27 11.5 0.0 2.4 1 1 1 2 2 2 0 Prolyl-tRNA synthetase, C-terminal Methyltransf_25 PF13649.6 CCF54395.1 - 0.056 14.2 0.0 0.16 12.7 0.0 1.9 1 0 0 1 1 1 0 Methyltransferase domain IgaA PF07095.11 CCF54395.1 - 0.11 10.5 0.2 6.8 4.5 0.0 2.2 2 0 0 2 2 2 0 Intracellular growth attenuator protein IgaA RdRP_4 PF02123.16 CCF54395.1 - 0.19 10.5 0.0 0.26 10.1 0.0 1.1 1 0 0 1 1 1 0 Viral RNA-directed RNA-polymerase MDM10 PF12519.8 CCF54396.1 - 7.3e-92 308.7 0.1 2e-56 191.8 0.1 2.2 2 0 0 2 2 2 2 Mitochondrial distribution and morphology protein 10 Nucleoporin_FG2 PF15967.5 CCF54397.1 - 0.0045 15.6 0.0 0.0045 15.6 0.0 4.2 2 1 1 4 4 4 1 Nucleoporin FG repeated region CCDC85 PF10226.9 CCF54397.1 - 0.015 15.0 0.6 0.03 14.0 0.4 1.6 1 1 0 1 1 1 0 CCDC85 family Nucleoporin_FG PF13634.6 CCF54397.1 - 0.072 13.9 84.9 41 5.1 44.3 3.8 1 1 1 2 2 2 0 Nucleoporin FG repeat region TFIIA PF03153.13 CCF54397.1 - 0.56 10.2 25.0 1.6 8.6 25.0 1.7 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Spt20 PF12090.8 CCF54397.1 - 2.9 7.4 23.5 3.4 7.2 13.0 2.3 2 0 0 2 2 2 0 Spt20 family DivIC PF04977.15 CCF54397.1 - 4.1 7.2 8.8 26 4.7 2.3 3.3 3 0 0 3 3 3 0 Septum formation initiator Med19 PF10278.9 CCF54398.1 - 0.012 15.6 0.0 0.024 14.6 0.0 1.4 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 FeS_assembly_P PF01883.19 CCF54399.1 - 3.1e-11 43.3 0.0 6.5e-11 42.3 0.0 1.6 1 0 0 1 1 1 1 Iron-sulfur cluster assembly protein FolB PF02152.18 CCF54399.1 - 0.048 14.2 0.2 0.55 10.8 0.0 2.2 1 1 0 2 2 2 0 Dihydroneopterin aldolase Cyclin PF08613.11 CCF54400.1 - 2e-30 106.3 4.7 2e-30 106.3 4.7 2.4 2 1 0 2 2 2 1 Cyclin Cyclin_N PF00134.23 CCF54400.1 - 9.3e-05 22.2 0.1 0.00014 21.6 0.1 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain PGAP1 PF07819.13 CCF54401.1 - 0.12 12.1 0.1 0.53 10.0 0.0 2.0 2 0 0 2 2 2 0 PGAP1-like protein FAA_hydrolase PF01557.18 CCF54402.1 - 5.7e-53 179.8 0.0 8e-53 179.3 0.0 1.2 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family FAA_hydrolase_N PF09298.11 CCF54402.1 - 8.7e-20 70.9 0.0 1.8e-19 69.9 0.0 1.6 2 0 0 2 2 2 1 Fumarylacetoacetase N-terminal p450 PF00067.22 CCF54403.1 - 1.8e-69 234.7 0.0 2.1e-69 234.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Fungal_trans PF04082.18 CCF54404.1 - 2.7e-23 82.3 0.1 4.6e-23 81.6 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCF54404.1 - 5.7e-08 32.7 8.4 1.6e-07 31.3 8.4 1.8 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 CCF54404.1 - 0.00072 18.5 3.1 0.0011 17.9 2.0 1.8 2 0 0 2 2 2 1 Fungal specific transcription factor domain Hemerythrin PF01814.23 CCF54405.1 - 2.5e-09 37.9 4.6 2.5e-09 37.9 4.6 1.7 1 1 0 2 2 2 1 Hemerythrin HHE cation binding domain PP2C_C PF07830.13 CCF54405.1 - 0.48 10.9 3.8 4 7.9 0.1 2.7 2 1 1 3 3 3 0 Protein serine/threonine phosphatase 2C, C-terminal domain HgmA PF04209.13 CCF54406.1 - 1.9e-190 633.1 0.6 2.1e-190 632.9 0.6 1.0 1 0 0 1 1 1 1 homogentisate 1,2-dioxygenase 4HBT_2 PF13279.6 CCF54408.1 - 1.2e-07 32.3 0.0 2.7e-07 31.1 0.0 1.6 1 1 0 1 1 1 1 Thioesterase-like superfamily AMP-binding PF00501.28 CCF54409.1 - 6.3e-18 64.6 0.0 7.6e-18 64.3 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme Agglutinin_C PF18021.1 CCF54410.1 - 0.068 13.7 0.0 0.13 12.8 0.0 1.4 1 0 0 1 1 1 0 Agglutinin C-terminal Condensation PF00668.20 CCF54411.1 - 7.4e-12 44.7 0.0 8.7e-12 44.4 0.0 1.0 1 0 0 1 1 1 1 Condensation domain NicO PF03824.16 CCF54412.1 - 1.3e-34 119.9 8.1 1e-33 116.9 1.5 3.8 2 2 0 2 2 2 1 High-affinity nickel-transport protein DUF4231 PF14015.6 CCF54412.1 - 0.34 11.4 6.1 6.4 7.3 1.0 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF4231) Ctr PF04145.15 CCF54412.1 - 4.5 7.9 5.3 50 4.5 5.3 2.8 1 1 0 1 1 1 0 Ctr copper transporter family Pkinase PF00069.25 CCF54413.1 - 2.1e-12 47.0 0.0 3.4e-12 46.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Seadorna_VP7 PF07387.11 CCF54413.1 - 9.1e-06 24.9 0.0 1.3e-05 24.4 0.0 1.1 1 0 0 1 1 1 1 Seadornavirus VP7 APH PF01636.23 CCF54413.1 - 5.2e-05 23.3 3.4 0.00043 20.3 0.1 3.0 2 1 1 3 3 3 1 Phosphotransferase enzyme family Kdo PF06293.14 CCF54413.1 - 0.021 14.2 0.0 0.049 13.0 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 CCF54413.1 - 0.1 11.4 0.7 0.35 9.6 0.0 1.9 2 0 0 2 2 2 0 Fungal protein kinase Choline_kinase PF01633.20 CCF54413.1 - 0.11 12.1 0.0 0.19 11.3 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase Kinase-like PF14531.6 CCF54413.1 - 0.17 11.2 0.0 0.27 10.5 0.0 1.2 1 0 0 1 1 1 0 Kinase-like tRNA_anti-codon PF01336.25 CCF54414.1 - 0.098 12.7 0.0 0.18 11.8 0.0 1.4 1 0 0 1 1 1 0 OB-fold nucleic acid binding domain RVT_2 PF07727.14 CCF54415.1 - 2.1e-55 188.0 2.1 2.4e-55 187.8 2.1 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) SRF-TF PF00319.18 CCF54417.1 - 1.3e-18 66.2 0.0 2e-18 65.6 0.0 1.3 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) Nop14 PF04147.12 CCF54417.1 - 0.83 7.8 6.0 0.045 12.0 0.8 1.5 2 0 0 2 2 2 0 Nop14-like family CENP-B_dimeris PF09026.10 CCF54417.1 - 2.5 8.5 12.9 6.8 7.1 12.9 1.7 1 0 0 1 1 1 0 Centromere protein B dimerisation domain U3_snoRNA_assoc PF08297.11 CCF54417.1 - 5.1 7.9 6.9 2.1 9.1 2.2 2.6 3 0 0 3 3 3 0 U3 snoRNA associated LAT PF15234.6 CCF54417.1 - 7 6.3 10.9 0.5 10.1 4.9 2.0 2 0 0 2 2 2 0 Linker for activation of T-cells AT_hook PF02178.19 CCF54417.1 - 7.4 6.8 12.6 0.21 11.6 5.7 2.3 2 0 0 2 2 2 0 AT hook motif ABC1 PF03109.16 CCF54418.1 - 1.2e-22 80.3 0.0 2.2e-22 79.4 0.0 1.5 1 0 0 1 1 1 1 ABC1 family RIO1 PF01163.22 CCF54418.1 - 0.074 12.7 0.0 0.21 11.2 0.0 1.8 2 0 0 2 2 2 0 RIO1 family Paf67 PF10255.9 CCF54420.1 - 3.6e-169 563.1 0.1 5.7e-169 562.4 0.1 1.3 1 0 0 1 1 1 1 RNA polymerase I-associated factor PAF67 TPR_2 PF07719.17 CCF54420.1 - 0.003 17.5 0.8 0.018 15.1 0.0 2.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 CCF54420.1 - 0.01 15.6 0.0 0.07 13.0 0.0 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat Med3 PF11593.8 CCF54420.1 - 9 5.4 8.1 17 4.4 8.1 1.3 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal FMN_dh PF01070.18 CCF54422.1 - 9.2e-32 110.4 0.0 1.2e-31 110.1 0.0 1.1 1 0 0 1 1 1 1 FMN-dependent dehydrogenase cNMP_binding PF00027.29 CCF54423.1 - 1.6e-26 92.2 0.0 1.7e-15 56.9 0.0 5.4 5 0 0 5 5 5 4 Cyclic nucleotide-binding domain Patatin PF01734.22 CCF54423.1 - 2.8e-15 57.0 10.0 8e-15 55.6 5.9 3.2 2 1 0 2 2 2 1 Patatin-like phospholipase Glycos_transf_2 PF00535.26 CCF54424.1 - 2.1e-23 83.0 0.0 4.1e-20 72.3 0.0 2.2 2 0 0 2 2 2 2 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 CCF54424.1 - 1.6e-08 34.8 0.2 9.3e-07 29.0 0.1 2.2 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Glyco_tranf_2_4 PF13704.6 CCF54424.1 - 0.12 12.9 0.0 0.27 11.8 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferase family 2 Glyco_tranf_2_2 PF10111.9 CCF54424.1 - 0.19 11.2 0.0 0.33 10.4 0.0 1.3 1 0 0 1 1 1 0 Glycosyltransferase like family 2 CLU_N PF15044.6 CCF54424.1 - 0.19 12.1 0.1 0.42 11.0 0.1 1.5 1 0 0 1 1 1 0 Mitochondrial function, CLU-N-term Peptidase_C1_2 PF03051.15 CCF54425.1 - 1.3e-144 482.2 0.1 6.1e-143 476.7 0.1 2.0 1 1 0 1 1 1 1 Peptidase C1-like family Peptidase_C1 PF00112.23 CCF54425.1 - 0.0043 17.2 4.7 0.66 10.0 0.0 3.0 3 1 0 3 3 3 2 Papain family cysteine protease HrcA_DNA-bdg PF03444.15 CCF54425.1 - 0.11 12.2 0.2 0.21 11.3 0.2 1.5 1 0 0 1 1 1 0 Winged helix-turn-helix transcription repressor, HrcA DNA-binding 2-Hacid_dh_C PF02826.19 CCF54427.1 - 2.4e-52 176.9 0.0 3.9e-52 176.2 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 CCF54427.1 - 5.5e-34 116.7 0.0 8.5e-34 116.1 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 CCF54427.1 - 0.00061 20.0 0.1 0.0022 18.2 0.1 2.0 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase AdoHcyase_NAD PF00670.21 CCF54427.1 - 0.0013 18.8 0.3 0.0039 17.3 0.0 1.9 2 0 0 2 2 2 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain RecO_C PF02565.15 CCF54427.1 - 0.033 14.0 0.0 0.066 13.0 0.0 1.4 1 0 0 1 1 1 0 Recombination protein O C terminal F-box-like PF12937.7 CCF54428.1 - 0.087 12.7 0.3 0.19 11.7 0.3 1.6 1 0 0 1 1 1 0 F-box-like DUF2433 PF10360.9 CCF54430.1 - 0.1 12.7 0.0 0.17 12.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2433) SRP-alpha_N PF04086.13 CCF54431.1 - 3.5e-52 178.2 1.9 3.5e-52 178.2 1.9 1.5 1 1 0 1 1 1 1 Signal recognition particle, alpha subunit, N-terminal SRP54 PF00448.22 CCF54431.1 - 2.5e-46 157.8 0.1 2.2e-45 154.7 0.1 2.3 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain SRP54_N PF02881.19 CCF54431.1 - 7.6e-10 38.9 0.0 2.3e-09 37.3 0.0 1.8 1 0 0 1 1 1 1 SRP54-type protein, helical bundle domain MeaB PF03308.16 CCF54431.1 - 2.2e-05 23.6 0.8 4.8e-05 22.5 0.0 1.8 2 1 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB CbiA PF01656.23 CCF54431.1 - 0.012 15.6 0.0 0.069 13.2 0.0 2.1 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain PI3K_1B_p101 PF10486.9 CCF54431.1 - 0.019 12.8 1.8 0.03 12.1 1.8 1.2 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit AAA_24 PF13479.6 CCF54431.1 - 0.061 13.1 0.0 0.44 10.2 0.0 2.3 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 CCF54431.1 - 0.13 12.3 4.7 0.83 9.8 0.8 3.3 2 1 0 2 2 2 0 50S ribosome-binding GTPase AAA_16 PF13191.6 CCF54431.1 - 0.57 10.5 0.0 0.57 10.5 0.0 2.6 3 1 0 3 3 3 0 AAA ATPase domain TFIIA PF03153.13 CCF54431.1 - 1.8 8.5 10.7 3 7.8 10.7 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit NOA36 PF06524.12 CCF54431.1 - 3.3 7.0 12.7 5.5 6.2 12.7 1.3 1 0 0 1 1 1 0 NOA36 protein Nop14 PF04147.12 CCF54431.1 - 3.8 5.6 9.0 6.2 4.9 9.0 1.3 1 0 0 1 1 1 0 Nop14-like family ATP_bind_1 PF03029.17 CCF54432.1 - 5.5e-85 285.0 0.0 6.4e-85 284.8 0.0 1.0 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein CLP1_P PF16575.5 CCF54432.1 - 2.1e-05 24.4 0.0 0.00066 19.5 0.0 2.4 2 0 0 2 2 2 1 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_18 PF13238.6 CCF54432.1 - 0.00035 21.1 0.0 0.00087 19.8 0.0 1.7 1 1 0 1 1 1 1 AAA domain T2SSE PF00437.20 CCF54432.1 - 0.00046 19.3 0.0 0.00064 18.9 0.0 1.2 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_16 PF13191.6 CCF54432.1 - 0.00088 19.7 0.1 0.026 14.9 0.0 2.6 3 0 0 3 3 3 1 AAA ATPase domain AAA_24 PF13479.6 CCF54432.1 - 0.0017 18.1 0.0 0.003 17.3 0.0 1.3 1 0 0 1 1 1 1 AAA domain CbiA PF01656.23 CCF54432.1 - 0.0018 18.3 0.0 0.002 18.2 0.0 1.3 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_30 PF13604.6 CCF54432.1 - 0.0022 17.8 0.0 0.0053 16.5 0.0 1.6 2 0 0 2 2 2 1 AAA domain AAA_31 PF13614.6 CCF54432.1 - 0.0029 17.6 0.1 0.45 10.4 0.3 2.3 1 1 1 2 2 2 1 AAA domain GTP_EFTU PF00009.27 CCF54432.1 - 0.0048 16.5 0.0 1.2 8.6 0.0 2.5 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain AAA PF00004.29 CCF54432.1 - 0.0058 17.1 0.0 0.083 13.3 0.0 2.3 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 CCF54432.1 - 0.0068 16.7 0.1 0.021 15.1 0.0 2.0 2 1 0 2 2 2 1 AAA domain MeaB PF03308.16 CCF54432.1 - 0.007 15.4 0.0 0.011 14.8 0.0 1.2 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_29 PF13555.6 CCF54432.1 - 0.01 15.5 0.0 0.019 14.7 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain FtsK_SpoIIIE PF01580.18 CCF54432.1 - 0.011 15.2 0.0 0.029 13.7 0.0 1.6 2 0 0 2 2 2 0 FtsK/SpoIIIE family RNA_helicase PF00910.22 CCF54432.1 - 0.012 16.0 0.0 0.064 13.7 0.0 2.3 3 0 0 3 3 2 0 RNA helicase AAA_14 PF13173.6 CCF54432.1 - 0.013 15.6 0.0 0.094 12.7 0.0 2.2 2 0 0 2 2 2 0 AAA domain NTPase_1 PF03266.15 CCF54432.1 - 0.017 15.0 0.0 0.097 12.6 0.0 2.0 2 0 0 2 2 2 0 NTPase MMR_HSR1 PF01926.23 CCF54432.1 - 0.032 14.3 0.0 0.072 13.2 0.0 1.7 1 1 0 1 1 1 0 50S ribosome-binding GTPase Clusterin PF01093.17 CCF54432.1 - 0.04 13.0 0.0 0.078 12.0 0.0 1.4 1 0 0 1 1 1 0 Clusterin AAA_19 PF13245.6 CCF54432.1 - 0.05 13.9 0.0 0.59 10.5 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 CCF54432.1 - 0.054 13.1 0.9 0.34 10.5 0.0 2.2 3 0 0 3 3 2 0 AAA domain ATPase PF06745.13 CCF54432.1 - 0.057 12.8 0.0 0.12 11.7 0.0 1.5 1 0 0 1 1 1 0 KaiC SRP54 PF00448.22 CCF54432.1 - 0.09 12.4 0.0 0.27 10.8 0.0 1.7 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_7 PF12775.7 CCF54432.1 - 0.11 12.0 0.0 0.74 9.3 0.0 2.1 2 0 0 2 2 2 0 P-loop containing dynein motor region NACHT PF05729.12 CCF54432.1 - 0.11 12.4 0.0 0.24 11.3 0.0 1.5 1 0 0 1 1 1 0 NACHT domain AAA_33 PF13671.6 CCF54432.1 - 0.11 12.6 0.0 0.2 11.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 CCF54432.1 - 0.12 12.8 0.0 0.32 11.5 0.0 1.7 1 0 0 1 1 1 0 ABC transporter AAA_10 PF12846.7 CCF54432.1 - 0.14 11.0 0.0 0.24 10.3 0.0 1.3 1 0 0 1 1 1 0 AAA-like domain RsgA_GTPase PF03193.16 CCF54432.1 - 0.14 12.0 0.1 5.4 6.9 0.0 2.7 3 0 0 3 3 3 0 RsgA GTPase Cytidylate_kin PF02224.18 CCF54432.1 - 0.15 11.8 0.1 0.27 11.0 0.1 1.4 1 0 0 1 1 1 0 Cytidylate kinase CobU PF02283.16 CCF54432.1 - 0.18 11.4 0.0 0.48 10.0 0.0 1.7 1 0 0 1 1 1 0 Cobinamide kinase / cobinamide phosphate guanyltransferase zf-RING_2 PF13639.6 CCF54433.1 - 7.5e-12 45.4 4.2 1.2e-11 44.7 4.2 1.3 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 CCF54433.1 - 5.7e-10 38.8 2.4 5.7e-10 38.8 2.4 2.0 2 0 0 2 2 2 1 RING-like zinc finger PA PF02225.22 CCF54433.1 - 7.7e-08 32.3 0.0 4e-07 30.0 0.0 2.3 2 1 0 2 2 2 1 PA domain zf-RING_5 PF14634.6 CCF54433.1 - 1.6e-05 24.8 1.7 2.6e-05 24.1 1.7 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 CCF54433.1 - 6.9e-05 22.6 3.3 0.00011 22.0 3.3 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CCF54433.1 - 0.00029 20.7 1.6 0.00045 20.0 1.6 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 CCF54433.1 - 0.0012 18.7 2.4 0.002 17.9 2.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 CCF54433.1 - 0.0015 18.8 4.8 0.0054 17.0 4.8 1.8 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 CCF54433.1 - 0.0016 18.5 9.0 0.0019 18.2 0.4 2.6 2 0 0 2 2 2 1 RING-type zinc-finger Prok-RING_4 PF14447.6 CCF54433.1 - 0.0037 17.1 4.0 0.0062 16.4 4.0 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 CCF54433.1 - 0.04 14.0 1.1 0.086 12.9 1.1 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger FANCL_C PF11793.8 CCF54433.1 - 0.11 12.7 3.2 0.59 10.4 3.2 2.1 1 1 0 1 1 1 0 FANCL C-terminal domain Zn_ribbon_17 PF17120.5 CCF54433.1 - 0.84 9.3 2.8 1.5 8.5 2.8 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type Iso_dh PF00180.20 CCF54434.1 - 3.3e-115 384.9 0.0 4e-115 384.7 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Cullin_binding PF03556.15 CCF54435.1 - 2.1e-35 121.8 1.8 3.6e-35 121.0 1.8 1.4 1 0 0 1 1 1 1 Cullin binding UBA_4 PF14555.6 CCF54435.1 - 1.7e-07 31.0 0.1 3.4e-07 30.0 0.1 1.6 1 0 0 1 1 1 1 UBA-like domain SlyX PF04102.12 CCF54435.1 - 0.064 13.9 0.8 2.1 9.0 0.1 2.6 2 0 0 2 2 2 0 SlyX Ribosomal_L5_C PF00673.21 CCF54436.1 - 2.5e-18 66.0 0.0 3.9e-18 65.4 0.0 1.3 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.19 CCF54436.1 - 3.8e-05 23.9 0.6 0.0054 17.0 0.1 2.5 2 0 0 2 2 2 2 Ribosomal protein L5 LSM PF01423.22 CCF54437.1 - 5.4e-20 70.9 0.4 6.7e-20 70.5 0.4 1.1 1 0 0 1 1 1 1 LSM domain DUF150_C PF17384.2 CCF54437.1 - 0.12 12.6 0.2 0.22 11.7 0.2 1.5 1 1 0 1 1 1 0 RimP C-terminal SH3 domain Aldedh PF00171.22 CCF54438.1 - 3.1e-106 355.7 0.0 3.9e-106 355.3 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family NOG1_N PF17835.1 CCF54440.1 - 2.9e-48 163.8 0.3 2.9e-48 163.8 0.3 2.0 2 0 0 2 2 2 1 NOG1 N-terminal helical domain NOG1 PF06858.14 CCF54440.1 - 1.2e-26 92.3 0.1 2.4e-26 91.3 0.1 1.6 1 0 0 1 1 1 1 Nucleolar GTP-binding protein 1 (NOG1) NOGCT PF08155.11 CCF54440.1 - 1.2e-26 92.4 3.2 3.2e-26 91.1 3.2 1.8 1 0 0 1 1 1 1 NOGCT (NUC087) domain MMR_HSR1 PF01926.23 CCF54440.1 - 4.3e-18 65.4 0.0 1e-17 64.2 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 CCF54440.1 - 2.6e-08 33.6 0.0 5.3e-08 32.5 0.0 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 CCF54440.1 - 0.011 15.8 0.1 1.5 8.8 0.0 2.7 1 1 1 2 2 2 0 Dynamin family AIG1 PF04548.16 CCF54440.1 - 0.017 14.4 0.0 0.033 13.5 0.0 1.5 1 0 0 1 1 1 0 AIG1 family Roc PF08477.13 CCF54440.1 - 0.098 12.9 0.0 0.53 10.5 0.0 2.1 1 1 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase RsgA_GTPase PF03193.16 CCF54440.1 - 0.16 11.8 0.0 1.3 8.9 0.0 2.6 2 1 0 2 2 2 0 RsgA GTPase NOA36 PF06524.12 CCF54440.1 - 0.58 9.4 4.5 1.2 8.4 4.5 1.5 1 0 0 1 1 1 0 NOA36 protein zf-C2H2 PF00096.26 CCF54443.1 - 0.00014 22.1 10.6 0.022 15.2 1.7 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 CCF54443.1 - 0.00019 21.7 7.3 0.0019 18.6 1.3 2.6 2 0 0 2 2 2 2 Zinc-finger double domain FOXP-CC PF16159.5 CCF54443.1 - 0.026 15.1 2.1 3.4 8.4 0.1 2.5 1 1 1 2 2 2 0 FOXP coiled-coil domain zf-C2H2_4 PF13894.6 CCF54443.1 - 1.2 10.2 7.1 16 6.7 0.7 2.9 2 0 0 2 2 2 0 C2H2-type zinc finger CHORD PF04968.12 CCF54443.1 - 3.1 8.6 5.2 30 5.4 1.8 2.4 1 1 1 2 2 2 0 CHORD Aminotran_5 PF00266.19 CCF54444.1 - 4.9e-33 114.6 0.0 6.7e-26 91.1 0.0 2.2 2 0 0 2 2 2 2 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 CCF54444.1 - 2.1e-06 26.5 0.0 3.8e-06 25.7 0.0 1.5 1 1 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Met_gamma_lyase PF06838.11 CCF54444.1 - 0.12 10.8 0.0 0.2 10.2 0.0 1.2 1 0 0 1 1 1 0 Methionine gamma-lyase zf-met2 PF12907.7 CCF54445.1 - 0.00026 21.1 1.8 0.00043 20.4 0.1 2.2 2 1 0 2 2 2 1 Zinc-binding zf-Di19 PF05605.12 CCF54445.1 - 0.0012 19.1 0.7 0.0018 18.5 0.7 1.2 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding zf_C2H2_ZHX PF18387.1 CCF54445.1 - 0.0058 16.2 0.1 0.0087 15.7 0.1 1.2 1 0 0 1 1 1 1 Zinc-fingers and homeoboxes C2H2 finger domain DUF1644 PF07800.12 CCF54445.1 - 0.019 15.1 0.2 0.029 14.4 0.2 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1644) MDM31_MDM32 PF08118.11 CCF54446.1 - 5.3e-187 622.7 0.2 1.2e-186 621.5 0.2 1.6 1 1 0 1 1 1 1 Yeast mitochondrial distribution and morphology (MDM) proteins Ank_5 PF13857.6 CCF54448.1 - 1.1e-08 35.1 0.7 0.00028 21.1 0.1 2.7 2 1 0 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 CCF54448.1 - 5.8e-08 33.2 0.1 1.8e-07 31.7 0.1 1.8 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CCF54448.1 - 8.1e-08 32.7 1.2 0.00064 20.2 0.2 3.5 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank PF00023.30 CCF54448.1 - 3.4e-06 27.2 0.2 0.062 13.8 0.0 3.7 4 0 0 4 4 4 2 Ankyrin repeat Ank_3 PF13606.6 CCF54448.1 - 7.3e-06 25.9 0.5 0.042 14.4 0.0 4.1 3 1 0 3 3 3 1 Ankyrin repeat Nrap_D4 PF17405.2 CCF54449.1 - 2.4e-58 197.0 0.0 3.9e-58 196.3 0.0 1.4 1 0 0 1 1 1 1 Nrap protein nucleotidyltransferase domain 4 Nrap_D2 PF17403.2 CCF54449.1 - 3.1e-49 166.6 0.0 5.3e-48 162.6 0.0 2.4 2 0 0 2 2 2 1 Nrap protein PAP/OAS-like domain Nrap_D5 PF17406.2 CCF54449.1 - 2.1e-44 151.2 0.0 9.8e-44 149.0 0.0 2.2 2 0 0 2 2 2 1 Nrap protein PAP/OAS1-like domain 5 Nrap PF03813.14 CCF54449.1 - 8.1e-43 146.1 0.0 1.4e-42 145.3 0.0 1.4 1 0 0 1 1 1 1 Nrap protein domain 1 Nrap_D3 PF17404.2 CCF54449.1 - 2.4e-41 141.5 0.0 4.3e-41 140.6 0.0 1.5 1 0 0 1 1 1 1 Nrap protein domain 3 Nrap_D6 PF17407.2 CCF54449.1 - 3e-36 124.6 0.0 7.1e-36 123.4 0.0 1.7 1 0 0 1 1 1 1 Nrap protein domain 6 SDA1 PF05285.12 CCF54449.1 - 1.2 8.4 28.6 2 7.8 28.6 1.2 1 0 0 1 1 1 0 SDA1 Nop14 PF04147.12 CCF54449.1 - 3.9 5.5 26.8 6.1 4.9 26.8 1.2 1 0 0 1 1 1 0 Nop14-like family PI31_Prot_N PF11566.8 CCF54450.1 - 1.3e-49 168.1 0.0 1.7e-49 167.8 0.0 1.1 1 0 0 1 1 1 1 PI31 proteasome regulator N-terminal PI31_Prot_C PF08577.11 CCF54450.1 - 3.3e-13 50.6 16.9 3.3e-13 50.6 16.9 3.4 2 1 1 3 3 3 1 PI31 proteasome regulator AvrD PF05655.11 CCF54450.1 - 0.099 12.0 0.0 0.14 11.4 0.0 1.1 1 0 0 1 1 1 0 Pseudomonas avirulence D protein (AvrD) DUF3747 PF12565.8 CCF54450.1 - 0.13 11.6 0.0 0.19 11.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3747) Adaptin_N PF01602.20 CCF54451.1 - 4.2e-100 335.8 7.3 6.4e-100 335.2 7.3 1.2 1 0 0 1 1 1 1 Adaptin N terminal region Coatomer_b_Cpla PF14806.6 CCF54451.1 - 8.9e-60 200.3 0.0 2.4e-59 198.9 0.0 1.8 1 0 0 1 1 1 1 Coatomer beta subunit appendage platform Coatamer_beta_C PF07718.12 CCF54451.1 - 1.4e-58 196.7 0.3 5.8e-58 194.8 0.2 2.2 2 0 0 2 2 2 1 Coatomer beta C-terminal region Cnd1 PF12717.7 CCF54451.1 - 1.4e-09 38.2 11.0 3.2e-07 30.5 0.0 4.0 3 1 1 4 4 4 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 CCF54451.1 - 2.2e-09 37.6 2.0 0.03 14.7 0.0 4.5 2 1 1 4 4 4 3 HEAT repeats HEAT PF02985.22 CCF54451.1 - 1.9e-06 27.6 0.3 0.031 14.5 0.0 4.5 4 0 0 4 4 4 1 HEAT repeat DUF5578 PF17741.1 CCF54451.1 - 0.0012 18.3 4.1 0.065 12.6 1.5 2.7 1 1 0 2 2 2 2 Family of unknown function (DUF5578) DUF5071 PF16804.5 CCF54451.1 - 0.016 15.5 3.1 0.28 11.4 0.0 3.5 2 1 1 3 3 3 0 Domain of unknown function (DUF5071) ParcG PF10274.9 CCF54451.1 - 0.021 15.0 2.3 0.97 9.5 0.0 2.7 2 0 0 2 2 2 0 Parkin co-regulated protein DUF3810 PF12725.7 CCF54451.1 - 0.027 13.8 0.8 0.075 12.4 0.8 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3810) DUF2875 PF11394.8 CCF54451.1 - 0.072 11.9 0.0 0.13 11.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2875) Arm PF00514.23 CCF54451.1 - 0.16 12.0 3.2 97 3.2 0.0 5.1 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat Acetyltransf_13 PF13880.6 CCF54452.1 - 1.1e-15 57.4 0.0 2.3e-15 56.3 0.0 1.5 1 0 0 1 1 1 1 ESCO1/2 acetyl-transferase zf-C2H2_3 PF13878.6 CCF54452.1 - 2.6e-11 43.2 1.7 4.7e-11 42.3 1.7 1.5 1 0 0 1 1 1 1 zinc-finger of acetyl-transferase ESCO Acetyltransf_1 PF00583.25 CCF54452.1 - 0.05 13.8 0.0 0.091 13.0 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 CCF54452.1 - 0.093 13.2 0.0 0.2 12.1 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain MutS_V PF00488.21 CCF54453.1 - 5.7e-66 222.1 0.4 9.7e-66 221.4 0.4 1.4 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 CCF54453.1 - 1.2e-34 120.2 0.2 3.4e-34 118.7 0.2 1.8 1 0 0 1 1 1 1 MutS domain III MutS_I PF01624.20 CCF54453.1 - 6e-34 116.7 0.0 1.3e-33 115.6 0.0 1.6 1 0 0 1 1 1 1 MutS domain I MutS_II PF05188.17 CCF54453.1 - 5.6e-10 39.6 0.0 1.7e-09 38.1 0.0 1.8 1 0 0 1 1 1 1 MutS domain II MutS_IV PF05190.18 CCF54453.1 - 1.3e-06 28.7 0.0 3.9e-06 27.1 0.0 1.8 1 0 0 1 1 1 1 MutS family domain IV Sec63 PF02889.16 CCF54454.1 - 1.4e-25 89.9 0.0 2.3e-25 89.2 0.0 1.3 1 0 0 1 1 1 1 Sec63 Brl domain DEAD PF00270.29 CCF54454.1 - 2.3e-23 82.8 0.0 7.7e-23 81.2 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.15 CCF54454.1 - 1.2e-12 48.1 0.0 2.1e-12 47.4 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 CCF54454.1 - 1.9e-09 37.8 0.0 1.1e-08 35.4 0.0 2.1 1 1 0 1 1 1 1 Helicase conserved C-terminal domain AAA_19 PF13245.6 CCF54454.1 - 0.00079 19.8 0.2 0.0071 16.7 0.0 2.2 2 0 0 2 2 2 1 AAA domain HHH_5 PF14520.6 CCF54454.1 - 0.0053 17.3 0.0 0.039 14.6 0.0 2.3 2 0 0 2 2 2 1 Helix-hairpin-helix domain DUF4332 PF14229.6 CCF54454.1 - 0.011 15.9 0.2 0.39 11.0 0.0 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4332) AAA_22 PF13401.6 CCF54454.1 - 0.024 14.9 0.0 0.08 13.2 0.0 1.9 1 0 0 1 1 1 0 AAA domain Pkinase PF00069.25 CCF54455.1 - 6.4e-44 150.3 0.0 2e-43 148.7 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF54455.1 - 1.7e-26 93.0 0.0 1.8e-25 89.7 0.0 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 CCF54455.1 - 0.0043 16.4 0.1 0.0073 15.7 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Herpes_ICP4_N PF03584.15 CCF54455.1 - 0.0059 16.5 0.0 0.016 15.1 0.0 1.6 1 0 0 1 1 1 1 Herpesvirus ICP4-like protein N-terminal region Enolase_C PF00113.22 CCF54456.1 - 1.7e-141 470.7 0.1 2.4e-141 470.2 0.1 1.1 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.16 CCF54456.1 - 2.5e-58 195.9 0.1 3.9e-58 195.3 0.1 1.3 1 0 0 1 1 1 1 Enolase, N-terminal domain MR_MLE_C PF13378.6 CCF54456.1 - 1e-07 31.8 0.0 1.6e-07 31.2 0.0 1.3 1 0 0 1 1 1 1 Enolase C-terminal domain-like MAAL_C PF07476.11 CCF54456.1 - 0.044 12.9 0.3 0.14 11.3 0.1 1.9 2 0 0 2 2 2 0 Methylaspartate ammonia-lyase C-terminus EMP24_GP25L PF01105.24 CCF54457.1 - 3.5e-40 137.9 0.1 4.4e-40 137.6 0.1 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Trimer_CC PF08954.11 CCF54457.1 - 0.061 12.9 0.1 0.11 12.1 0.1 1.3 1 0 0 1 1 1 0 Trimerisation motif DUF4806 PF16064.5 CCF54457.1 - 0.12 12.6 0.2 0.26 11.6 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4806) Nop10p PF04135.12 CCF54458.1 - 1.7e-20 72.8 0.2 2e-20 72.6 0.2 1.1 1 0 0 1 1 1 1 Nucleolar RNA-binding protein, Nop10p family Josephin PF02099.17 CCF54459.1 - 7.5e-47 159.5 0.2 1.7e-46 158.3 0.2 1.6 1 0 0 1 1 1 1 Josephin OAD_gamma PF04277.13 CCF54459.1 - 2.9 8.5 6.1 6.9 7.3 0.0 3.6 3 0 0 3 3 3 0 Oxaloacetate decarboxylase, gamma chain UIM PF02809.20 CCF54459.1 - 3.2 7.9 38.4 0.064 13.2 1.6 4.7 5 0 0 5 5 5 0 Ubiquitin interaction motif Mito_carr PF00153.27 CCF54460.1 - 1e-55 185.6 5.6 2.3e-18 65.9 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein KCH PF16944.5 CCF54461.1 - 6.2e-86 288.2 11.4 8.2e-86 287.8 11.4 1.1 1 0 0 1 1 1 1 Fungal potassium channel FAM163 PF15069.6 CCF54461.1 - 0.11 13.0 0.0 0.23 11.9 0.0 1.5 1 0 0 1 1 1 0 FAM163 family Glyoxalase PF00903.25 CCF54462.1 - 0.00093 19.4 0.0 0.0013 19.0 0.0 1.4 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily ICAT PF06384.11 CCF54463.1 - 0.13 12.5 0.0 0.37 11.1 0.0 1.7 1 0 0 1 1 1 0 Beta-catenin-interacting protein ICAT WD40 PF00400.32 CCF54464.1 - 4.5e-39 131.7 17.7 1.3e-06 29.0 0.3 7.7 8 0 0 8 8 8 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF54464.1 - 2e-13 50.4 0.1 0.013 15.7 0.0 5.0 2 1 4 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CCF54464.1 - 1.1e-05 24.6 0.3 0.00058 18.9 0.1 2.6 2 1 1 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 CCF54464.1 - 4e-05 23.1 0.2 0.58 9.4 0.1 3.0 2 1 0 3 3 3 2 WD40-like domain Cytochrom_D1 PF02239.16 CCF54464.1 - 4.2e-05 22.3 0.0 7.1e-05 21.5 0.0 1.3 1 0 0 1 1 1 1 Cytochrome D1 heme domain Frtz PF11768.8 CCF54464.1 - 0.012 14.0 0.1 1.2 7.3 0.0 2.8 3 0 0 3 3 3 0 WD repeat-containing and planar cell polarity effector protein Fritz Nucleoporin_N PF08801.11 CCF54464.1 - 0.024 13.4 2.1 0.17 10.6 0.7 2.4 1 1 1 2 2 2 0 Nup133 N terminal like Nbas_N PF15492.6 CCF54464.1 - 0.065 12.6 0.1 1 8.6 0.0 2.5 2 0 0 2 2 2 0 Neuroblastoma-amplified sequence, N terminal GTP_EFTU PF00009.27 CCF54465.1 - 6.9e-55 185.6 0.0 1.6e-54 184.4 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_C PF00679.24 CCF54465.1 - 5.2e-14 52.0 0.0 1.2e-13 50.9 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_II PF14492.6 CCF54465.1 - 5.7e-09 35.9 0.1 2.1e-07 30.9 0.0 2.8 3 0 0 3 3 3 1 Elongation Factor G, domain II MMR_HSR1 PF01926.23 CCF54465.1 - 0.00019 21.5 0.0 0.00063 19.8 0.0 1.9 1 0 0 1 1 1 1 50S ribosome-binding GTPase EFG_IV PF03764.18 CCF54465.1 - 0.00058 19.6 0.0 0.0027 17.5 0.0 2.2 2 0 0 2 2 2 1 Elongation factor G, domain IV MSP1_C PF07462.11 CCF54465.1 - 0.0047 15.7 0.2 0.013 14.3 0.2 1.6 1 0 0 1 1 1 1 Merozoite surface protein 1 (MSP1) C-terminus GTP_EFTU_D2 PF03144.25 CCF54465.1 - 0.014 15.8 0.0 0.046 14.1 0.0 2.0 1 1 0 1 1 1 0 Elongation factor Tu domain 2 RsgA_GTPase PF03193.16 CCF54465.1 - 0.15 12.0 0.0 2.6 7.9 0.0 2.7 2 0 0 2 2 2 0 RsgA GTPase CENP-B_dimeris PF09026.10 CCF54465.1 - 0.45 10.9 7.3 16 6.0 0.0 2.5 2 0 0 2 2 2 0 Centromere protein B dimerisation domain XRN_M PF17846.1 CCF54465.1 - 2.1 7.2 8.4 0.24 10.3 3.3 1.9 2 0 0 2 2 2 0 Xrn1 helical domain ADH_zinc_N_2 PF13602.6 CCF54467.1 - 1.4e-09 39.0 0.0 4.1e-09 37.6 0.0 1.8 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CCF54467.1 - 4.4e-06 26.6 0.1 8.2e-06 25.7 0.1 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CCF54467.1 - 0.019 15.0 0.0 0.036 14.0 0.0 1.5 1 0 0 1 1 1 0 Zinc-binding dehydrogenase RRM_1 PF00076.22 CCF54468.1 - 4.2e-17 61.7 0.0 6.7e-17 61.1 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4865 PF16157.5 CCF54468.1 - 0.22 11.5 3.6 0.38 10.7 3.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4865) CTNNBL PF08216.11 CCF54469.1 - 1.7e-32 111.7 0.0 3.5e-32 110.7 0.0 1.5 1 0 0 1 1 1 1 Catenin-beta-like, Arm-motif containing nuclear Drf_GBD PF06371.13 CCF54469.1 - 0.00086 18.9 0.0 0.0042 16.7 0.0 2.1 3 0 0 3 3 3 1 Diaphanous GTPase-binding Domain Arm_3 PF16186.5 CCF54469.1 - 0.14 11.8 0.0 0.14 11.8 0.0 2.6 3 0 0 3 3 3 0 Atypical Arm repeat DUF3446 PF11928.8 CCF54469.1 - 0.53 10.6 7.0 3.2 8.1 0.1 2.6 2 0 0 2 2 2 0 Early growth response N-terminal domain Abhydrolase_6 PF12697.7 CCF54470.1 - 0.00025 21.7 1.1 0.00061 20.5 0.5 1.9 1 1 0 1 1 1 1 Alpha/beta hydrolase family Lipase_3 PF01764.25 CCF54470.1 - 0.0025 17.7 0.0 0.0041 17.0 0.0 1.4 1 0 0 1 1 1 1 Lipase (class 3) DUF676 PF05057.14 CCF54470.1 - 0.0039 16.7 0.1 0.031 13.8 0.1 2.0 1 1 0 1 1 1 1 Putative serine esterase (DUF676) PGAP1 PF07819.13 CCF54470.1 - 0.033 13.9 0.9 0.062 13.0 0.9 1.5 1 1 0 1 1 1 0 PGAP1-like protein Thioesterase PF00975.20 CCF54470.1 - 0.034 14.3 0.1 0.066 13.3 0.1 1.4 1 0 0 1 1 1 0 Thioesterase domain Hydrolase_4 PF12146.8 CCF54470.1 - 0.038 13.3 0.2 0.08 12.2 0.2 1.4 1 0 0 1 1 1 0 Serine aminopeptidase, S33 DUF2974 PF11187.8 CCF54470.1 - 0.038 13.5 0.1 0.063 12.8 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) DUF4366 PF14283.6 CCF54470.1 - 0.1 12.7 0.0 0.24 11.5 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) API5 PF05918.11 CCF54471.1 - 0.85 8.4 2.8 1.8 7.3 2.8 1.5 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) Cofilin_ADF PF00241.20 CCF54472.1 - 9.5e-20 70.6 0.0 1.1e-19 70.5 0.0 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein TraX PF05857.11 CCF54472.1 - 0.11 12.6 0.0 0.14 12.2 0.0 1.1 1 0 0 1 1 1 0 TraX protein ox_reductase_C PF08635.10 CCF54473.1 - 7.3e-77 255.8 0.1 1.1e-76 255.3 0.1 1.2 1 0 0 1 1 1 1 Putative oxidoreductase C terminal domain GFO_IDH_MocA PF01408.22 CCF54473.1 - 7.8e-28 97.7 0.0 1.6e-27 96.7 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 CCF54473.1 - 0.0086 16.1 0.0 0.02 14.9 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain Peptidase_M24 PF00557.24 CCF54474.1 - 2.4e-44 151.5 0.1 3.4e-44 151.1 0.1 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 Creatinase_N_2 PF16189.5 CCF54474.1 - 4.3e-41 140.7 0.0 1.5e-39 135.7 0.0 2.4 2 0 0 2 2 2 1 Creatinase/Prolidase N-terminal domain Peptidase_M24_C PF16188.5 CCF54474.1 - 6.6e-16 58.1 0.1 2e-15 56.6 0.1 1.9 1 0 0 1 1 1 1 C-terminal region of peptidase_M24 Creatinase_N PF01321.18 CCF54474.1 - 2.6e-15 57.2 0.0 1.4e-14 54.9 0.0 2.2 2 0 0 2 2 2 1 Creatinase/Prolidase N-terminal domain RRM_1 PF00076.22 CCF54475.1 - 3.4e-26 90.8 0.1 1.2e-15 57.1 0.0 3.5 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 CCF54475.1 - 6.4e-05 22.9 0.0 0.00043 20.2 0.0 2.1 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.11 CCF54475.1 - 0.0024 17.9 1.0 0.004 17.2 0.0 1.8 2 0 0 2 2 1 1 RNA binding motif RRM_7 PF16367.5 CCF54475.1 - 0.0035 17.4 0.0 0.26 11.5 0.0 2.9 2 0 0 2 2 2 1 RNA recognition motif PAT1 PF09770.9 CCF54475.1 - 0.029 12.7 19.2 0.04 12.2 19.2 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 RRM_occluded PF16842.5 CCF54475.1 - 0.18 11.7 0.0 0.35 10.8 0.0 1.4 1 0 0 1 1 1 0 Occluded RNA-recognition motif Presenilin PF01080.17 CCF54475.1 - 0.82 8.4 12.2 1.2 7.8 12.2 1.2 1 0 0 1 1 1 0 Presenilin Macoilin PF09726.9 CCF54475.1 - 1.4 7.4 9.9 2.1 6.8 9.9 1.2 1 0 0 1 1 1 0 Macoilin family Otopetrin PF03189.13 CCF54475.1 - 1.6 7.5 3.7 2.2 7.0 3.7 1.1 1 0 0 1 1 1 0 Otopetrin FAM76 PF16046.5 CCF54475.1 - 2 7.7 12.0 3.2 7.0 12.0 1.2 1 0 0 1 1 1 0 FAM76 protein Band_3_cyto PF07565.13 CCF54475.1 - 8.9 6.0 11.5 15 5.3 11.5 1.3 1 0 0 1 1 1 0 Band 3 cytoplasmic domain TBCA PF02970.16 CCF54476.1 - 1.2e-18 67.2 2.5 1.7e-18 66.7 2.5 1.3 1 0 0 1 1 1 1 Tubulin binding cofactor A UCH PF00443.29 CCF54477.1 - 1.3e-49 169.0 0.0 2.6e-49 168.1 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 CCF54477.1 - 4.6e-20 72.5 2.5 1.4e-19 70.9 0.0 2.6 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase Sgf11 PF08209.11 CCF54477.1 - 1.3 8.7 3.9 1.4 8.6 0.1 2.3 2 0 0 2 2 2 0 Sgf11 (transcriptional regulation protein) DZR PF12773.7 CCF54477.1 - 2.3 8.3 4.7 32 4.7 5.5 2.2 1 1 1 2 2 2 0 Double zinc ribbon Vac14_Fig4_bd PF11916.8 CCF54478.1 - 1.9e-79 265.5 10.3 7.5e-79 263.5 8.5 2.4 2 0 0 2 2 2 1 Vacuolar protein 14 C-terminal Fig4p binding Vac14_Fab1_bd PF12755.7 CCF54478.1 - 1.8e-42 143.9 0.0 1.3e-39 134.7 0.0 3.6 3 0 0 3 3 3 1 Vacuolar 14 Fab1-binding region HEAT PF02985.22 CCF54478.1 - 6.7e-13 47.7 2.0 0.002 18.3 0.0 6.5 6 0 0 6 6 6 2 HEAT repeat Cnd1 PF12717.7 CCF54478.1 - 1.4e-08 34.9 1.5 0.00045 20.3 0.5 3.6 3 0 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 CCF54478.1 - 1.1e-06 29.0 3.9 0.47 10.9 0.1 5.6 4 1 0 5 5 5 2 HEAT repeats HEAT_EZ PF13513.6 CCF54478.1 - 6.3e-05 23.4 4.2 1.8 9.2 0.0 5.6 5 0 0 5 5 5 2 HEAT-like repeat CLASP_N PF12348.8 CCF54478.1 - 0.0023 17.5 0.4 6.1 6.3 0.0 4.1 3 1 0 4 4 4 1 CLASP N terminal MMS19_C PF12460.8 CCF54478.1 - 0.0048 16.1 6.3 0.013 14.6 0.0 3.4 4 0 0 4 4 4 1 RNAPII transcription regulator C-terminal Dopey_N PF04118.14 CCF54478.1 - 0.0062 15.7 0.2 3.3 6.7 0.1 3.3 3 0 0 3 3 3 1 Dopey, N-terminal Tti2 PF10521.9 CCF54478.1 - 0.022 14.3 0.8 2.7 7.5 0.0 3.7 4 1 1 5 5 5 0 Tti2 family PNISR PF15996.5 CCF54478.1 - 0.063 13.6 5.2 0.12 12.7 5.2 1.4 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR RasGEF_N_2 PF14663.6 CCF54478.1 - 0.18 12.2 0.9 49 4.4 0.1 3.7 3 1 1 4 4 4 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain Proteasome PF00227.26 CCF54479.1 - 3.2e-43 147.4 0.1 3.7e-43 147.2 0.1 1.0 1 0 0 1 1 1 1 Proteasome subunit Vta1 PF04652.16 CCF54479.1 - 0.091 12.7 0.0 0.15 12.0 0.0 1.3 1 0 0 1 1 1 0 Vta1 like EF-hand_1 PF00036.32 CCF54480.1 - 3.9e-27 91.7 11.9 9e-08 31.1 0.3 4.2 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 CCF54480.1 - 1.1e-22 80.3 5.6 5.2e-13 49.2 0.9 2.7 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 CCF54480.1 - 5.4e-21 72.7 9.2 2.4e-05 23.9 0.1 4.3 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 CCF54480.1 - 3.7e-19 67.3 13.4 4.1e-07 29.2 0.4 4.3 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 CCF54480.1 - 3.6e-13 49.1 12.4 0.00042 20.1 0.4 4.3 2 1 2 4 4 4 4 EF-hand domain pair SPARC_Ca_bdg PF10591.9 CCF54480.1 - 1.8e-06 28.2 0.0 0.016 15.5 0.1 2.4 2 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.6 CCF54480.1 - 6.4e-06 26.4 0.1 0.14 12.5 0.1 3.1 2 1 1 3 3 3 2 EF-hand domain EF-hand_4 PF12763.7 CCF54480.1 - 3e-05 23.9 8.0 0.0064 16.4 0.4 3.9 1 1 3 4 4 4 1 Cytoskeletal-regulatory complex EF hand Dockerin_1 PF00404.18 CCF54480.1 - 0.065 13.4 3.2 1.6 9.0 2.7 2.9 2 1 0 2 2 2 0 Dockerin type I domain TM231 PF10149.9 CCF54480.1 - 0.14 11.4 0.2 0.22 10.8 0.2 1.4 1 0 0 1 1 1 0 Transmembrane protein 231 VCBS PF13517.6 CCF54480.1 - 0.17 12.5 1.4 15 6.3 0.1 2.5 2 1 0 2 2 2 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella Ribosomal_S13 PF00416.22 CCF54481.1 - 9.1e-21 74.6 0.1 1.9e-11 44.4 0.6 2.1 2 0 0 2 2 2 2 Ribosomal protein S13/S18 FbpA PF05833.11 CCF54481.1 - 6.3e-05 21.9 0.0 9.1e-05 21.4 0.0 1.2 1 0 0 1 1 1 1 Fibronectin-binding protein A N-terminus (FbpA) Med13_C PF06333.12 CCF54481.1 - 0.012 14.9 1.3 0.013 14.8 1.3 1.1 1 0 0 1 1 1 0 Mediator complex subunit 13 C-terminal domain LisH PF08513.11 CCF54482.1 - 9.3e-06 25.4 0.0 1.6e-05 24.6 0.0 1.4 1 0 0 1 1 1 1 LisH TFIIA PF03153.13 CCF54482.1 - 0.0009 19.3 38.0 0.0009 19.3 38.0 4.8 2 1 1 4 4 4 1 Transcription factor IIA, alpha/beta subunit Cpn60_TCP1 PF00118.24 CCF54483.1 - 2.9e-151 504.4 13.2 3.3e-151 504.3 13.2 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Sua5_yciO_yrdC PF01300.18 CCF54483.1 - 0.012 15.1 0.2 0.031 13.8 0.1 1.7 2 0 0 2 2 2 0 Telomere recombination LSM PF01423.22 CCF54484.1 - 9.6e-21 73.2 0.0 1.1e-20 73.1 0.0 1.0 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 CCF54484.1 - 0.0037 17.4 0.0 0.0043 17.2 0.0 1.1 1 0 0 1 1 1 1 Ataxin 2 SM domain MFS_2 PF13347.6 CCF54485.1 - 8.5e-11 41.1 7.3 8.5e-11 41.1 7.3 2.4 2 0 0 2 2 2 1 MFS/sugar transport protein MFS_1 PF07690.16 CCF54485.1 - 1.4e-09 37.3 13.2 1.4e-09 37.3 13.2 3.0 3 0 0 3 3 3 2 Major Facilitator Superfamily PsaM PF07465.13 CCF54485.1 - 0.16 11.7 2.4 0.26 11.0 0.7 2.4 2 0 0 2 2 2 0 Photosystem I protein M (PsaM) Trp_oprn_chp PF09534.10 CCF54485.1 - 2.1 8.1 7.6 0.8 9.5 0.1 2.8 2 1 0 2 2 2 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) DUF5527 PF17665.1 CCF54485.1 - 8.1 6.0 5.6 18 4.9 2.1 2.6 2 1 1 3 3 3 0 Family of unknown function (DUF5527) RasGAP PF00616.19 CCF54486.1 - 8.8e-23 81.1 0.0 3e-15 56.5 0.0 2.5 1 1 1 2 2 2 2 GTPase-activator protein for Ras-like GTPase CRAL_TRIO_2 PF13716.6 CCF54486.1 - 5.1e-07 29.9 0.5 1.6e-06 28.3 0.1 2.1 2 0 0 2 2 2 1 Divergent CRAL/TRIO domain MOR2-PAG1_C PF14225.6 CCF54486.1 - 8.8e-05 22.5 0.0 0.00033 20.6 0.0 2.0 1 0 0 1 1 1 1 Cell morphogenesis C-terminal ImpA_N PF06812.12 CCF54486.1 - 0.15 12.2 0.1 1.6 8.9 0.0 2.6 2 0 0 2 2 2 0 ImpA, N-terminal, type VI secretion system TCTP PF00838.17 CCF54487.1 - 1.4e-72 243.5 0.5 1.5e-72 243.3 0.5 1.0 1 0 0 1 1 1 1 Translationally controlled tumour protein AAA PF00004.29 CCF54488.1 - 9.4e-54 181.4 0.0 1.5e-37 129.0 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) CDC48_2 PF02933.17 CCF54488.1 - 3.9e-10 39.4 0.4 6e-09 35.6 0.0 2.6 2 0 0 2 2 2 1 Cell division protein 48 (CDC48), domain 2 AAA_16 PF13191.6 CCF54488.1 - 1.1e-09 38.9 0.3 0.0027 18.1 0.2 3.3 2 2 1 3 3 3 2 AAA ATPase domain AAA_22 PF13401.6 CCF54488.1 - 1.2e-09 38.6 1.2 0.00079 19.7 0.1 4.5 3 2 1 4 4 4 2 AAA domain AAA_lid_3 PF17862.1 CCF54488.1 - 4e-09 36.1 0.0 8.3e-09 35.1 0.0 1.5 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 CCF54488.1 - 8e-09 35.6 0.0 0.00033 20.7 0.0 2.8 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 CCF54488.1 - 2.5e-08 34.2 0.1 0.00013 22.2 0.0 3.0 2 1 0 2 2 2 2 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 CCF54488.1 - 2e-07 30.9 0.4 0.015 15.1 0.0 2.9 3 0 0 3 3 3 2 Holliday junction DNA helicase RuvB P-loop domain NACHT PF05729.12 CCF54488.1 - 3.2e-07 30.4 0.3 0.034 14.0 0.0 3.7 3 1 0 3 3 3 2 NACHT domain AAA_24 PF13479.6 CCF54488.1 - 7.1e-07 29.2 0.0 0.024 14.3 0.0 2.9 2 1 0 2 2 2 2 AAA domain TIP49 PF06068.13 CCF54488.1 - 1.1e-06 28.2 0.0 0.014 14.6 0.0 2.2 2 0 0 2 2 2 2 TIP49 P-loop domain AAA_33 PF13671.6 CCF54488.1 - 1.1e-06 28.8 0.0 0.036 14.2 0.0 2.4 2 0 0 2 2 2 2 AAA domain Mg_chelatase PF01078.21 CCF54488.1 - 1.6e-06 27.6 0.4 0.011 15.2 0.1 2.5 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 CCF54488.1 - 6.9e-06 25.9 0.1 0.027 14.2 0.0 2.7 2 0 0 2 2 2 2 IstB-like ATP binding protein RNA_helicase PF00910.22 CCF54488.1 - 1.2e-05 25.6 0.0 0.043 14.2 0.0 2.5 2 0 0 2 2 2 2 RNA helicase ABC_tran PF00005.27 CCF54488.1 - 2.4e-05 24.8 0.3 0.098 13.2 0.1 3.2 3 0 0 3 3 3 1 ABC transporter AAA_18 PF13238.6 CCF54488.1 - 3.6e-05 24.3 0.0 0.074 13.6 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_14 PF13173.6 CCF54488.1 - 4.4e-05 23.5 0.0 0.089 12.8 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_28 PF13521.6 CCF54488.1 - 4.7e-05 23.7 0.0 0.069 13.4 0.0 2.4 2 0 0 2 2 2 2 AAA domain ATPase_2 PF01637.18 CCF54488.1 - 5.8e-05 23.1 0.2 1.2 9.0 0.1 3.8 3 1 0 3 3 3 1 ATPase domain predominantly from Archaea TsaE PF02367.17 CCF54488.1 - 5.9e-05 23.1 0.0 0.16 12.0 0.0 2.5 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE NB-ARC PF00931.22 CCF54488.1 - 8.3e-05 21.9 0.0 0.42 9.7 0.0 2.6 2 0 0 2 2 2 2 NB-ARC domain AAA_30 PF13604.6 CCF54488.1 - 0.00018 21.3 0.1 0.31 10.7 0.0 2.5 2 0 0 2 2 2 2 AAA domain PhoH PF02562.16 CCF54488.1 - 0.00023 20.7 0.0 0.68 9.3 0.0 2.4 2 0 0 2 2 2 2 PhoH-like protein Sigma54_activat PF00158.26 CCF54488.1 - 0.00027 20.7 0.0 0.57 9.9 0.0 2.7 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_25 PF13481.6 CCF54488.1 - 0.00037 20.1 2.0 0.9 9.1 0.0 3.6 4 0 0 4 4 4 2 AAA domain ATPase PF06745.13 CCF54488.1 - 0.00056 19.3 0.1 0.13 11.5 0.0 2.5 2 0 0 2 2 2 1 KaiC AAA_7 PF12775.7 CCF54488.1 - 0.00087 18.8 0.1 0.2 11.1 0.0 2.3 2 0 0 2 2 2 1 P-loop containing dynein motor region Parvo_NS1 PF01057.17 CCF54488.1 - 0.00094 18.3 0.0 0.83 8.7 0.0 2.3 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 AAA_11 PF13086.6 CCF54488.1 - 0.001 18.9 0.1 1.4 8.6 0.0 2.3 2 0 0 2 2 2 2 AAA domain AAA_3 PF07726.11 CCF54488.1 - 0.0024 17.7 0.0 0.83 9.5 0.0 2.8 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.6 CCF54488.1 - 0.0039 17.5 1.4 1.6 9.1 0.1 2.9 3 0 0 3 3 2 1 AAA domain DUF2075 PF09848.9 CCF54488.1 - 0.0052 16.1 0.2 2 7.6 0.1 2.5 2 1 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) AAA_17 PF13207.6 CCF54488.1 - 0.01 16.2 0.0 4.2 7.8 0.0 3.2 2 0 0 2 2 2 0 AAA domain DAP3 PF10236.9 CCF54488.1 - 0.022 13.9 0.0 6.3 5.9 0.0 2.4 2 1 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 cobW PF02492.19 CCF54488.1 - 0.032 13.8 0.1 5 6.7 0.0 2.8 3 0 0 3 3 2 0 CobW/HypB/UreG, nucleotide-binding domain Zeta_toxin PF06414.12 CCF54488.1 - 0.035 13.4 0.1 1.1 8.5 0.0 2.6 2 0 0 2 2 2 0 Zeta toxin KTI12 PF08433.10 CCF54488.1 - 0.076 12.5 0.1 4.8 6.5 0.0 2.3 2 0 0 2 2 2 0 Chromatin associated protein KTI12 DEAD PF00270.29 CCF54488.1 - 0.079 12.7 1.3 37 4.0 0.1 3.6 2 2 1 4 4 4 0 DEAD/DEAH box helicase CPT PF07931.12 CCF54488.1 - 0.13 12.1 0.0 0.62 9.9 0.0 2.0 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein NTPase_1 PF03266.15 CCF54488.1 - 0.14 12.1 0.1 18 5.2 0.0 2.7 2 0 0 2 2 2 0 NTPase Hydin_ADK PF17213.3 CCF54488.1 - 0.17 12.1 0.3 1.5 9.1 0.1 2.2 2 0 0 2 2 2 0 Hydin Adenylate kinase-like domain NUDIX PF00293.28 CCF54489.1 - 4e-11 43.1 0.3 6e-11 42.5 0.3 1.5 1 1 0 1 1 1 1 NUDIX domain MPDZ_u10 PF16667.5 CCF54489.1 - 0.16 12.9 3.4 1.5 9.7 0.2 2.8 3 0 0 3 3 3 0 Unstructured region 10 on multiple PDZ protein PP2C PF00481.21 CCF54490.1 - 4.5e-33 115.0 0.0 3.2e-30 105.6 0.0 2.3 2 0 0 2 2 2 2 Protein phosphatase 2C POX PF07526.11 CCF54493.1 - 0.038 14.6 1.4 0.044 14.3 0.2 1.7 2 0 0 2 2 2 0 Associated with HOX He_PIG PF05345.12 CCF54494.1 - 1e-08 35.2 14.3 0.00039 20.6 0.3 5.0 4 1 0 4 4 4 3 Putative Ig domain TRAPP PF04051.16 CCF54495.1 - 1.8e-37 128.3 0.0 2.2e-37 128.0 0.0 1.1 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component Caps_synth_GfcC PF06251.11 CCF54496.1 - 0.11 12.1 3.8 0.27 10.8 3.8 1.6 1 0 0 1 1 1 0 Capsule biosynthesis GfcC Phosducin PF02114.16 CCF54496.1 - 2.2 7.1 5.8 3.9 6.3 5.8 1.3 1 0 0 1 1 1 0 Phosducin Macoilin PF09726.9 CCF54496.1 - 6.4 5.2 19.4 17 3.8 19.4 1.7 1 0 0 1 1 1 0 Macoilin family DUF4407 PF14362.6 CCF54496.1 - 9.3 5.5 8.1 17 4.6 8.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) CSN8_PSD8_EIF3K PF10075.9 CCF54497.1 - 6.5e-30 104.0 0.1 9e-30 103.5 0.1 1.2 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family SAC3_GANP PF03399.16 CCF54497.1 - 0.001 18.6 0.0 0.0014 18.0 0.0 1.2 1 0 0 1 1 1 1 SAC3/GANP family PCI PF01399.27 CCF54497.1 - 0.023 15.2 0.2 0.68 10.5 0.2 2.8 2 1 0 2 2 2 0 PCI domain IMS PF00817.20 CCF54499.1 - 1.8e-38 131.9 0.0 3.6e-38 130.9 0.0 1.5 1 0 0 1 1 1 1 impB/mucB/samB family IMS_C PF11799.8 CCF54499.1 - 4.3e-14 53.2 0.1 1.3e-13 51.7 0.1 1.9 2 0 0 2 2 2 1 impB/mucB/samB family C-terminal domain UBM PF14377.6 CCF54499.1 - 1e-07 31.1 0.2 2.5e-07 29.9 0.2 1.6 1 0 0 1 1 1 1 Ubiquitin binding region IMS_HHH PF11798.8 CCF54499.1 - 0.012 15.9 0.0 0.04 14.2 0.0 1.9 1 0 0 1 1 1 0 IMS family HHH motif zf-trcl PF13451.6 CCF54499.1 - 0.12 12.3 0.1 8.1 6.4 0.2 2.4 2 0 0 2 2 2 0 Probable zinc-ribbon domain BIR PF00653.21 CCF54499.1 - 0.13 12.9 0.2 20 5.9 0.0 2.6 2 0 0 2 2 2 0 Inhibitor of Apoptosis domain zf_UBZ PF18439.1 CCF54499.1 - 0.22 11.1 4.2 0.74 9.5 0.3 2.5 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger Cyt-b5 PF00173.28 CCF54500.1 - 3.3e-24 84.8 0.0 5.2e-24 84.2 0.0 1.3 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain TB2_DP1_HVA22 PF03134.19 CCF54501.1 - 2e-08 34.1 0.5 3.9e-08 33.1 0.5 1.5 1 0 0 1 1 1 1 TB2/DP1, HVA22 family AAA PF00004.29 CCF54502.1 - 7e-92 304.8 0.0 2.6e-46 157.3 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 CCF54502.1 - 6.3e-24 83.5 0.7 5.4e-11 42.1 0.2 2.5 2 0 0 2 2 2 2 AAA+ lid domain RuvB_N PF05496.12 CCF54502.1 - 3.5e-15 56.1 0.0 9.2e-08 32.0 0.0 2.7 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 CCF54502.1 - 7.7e-11 42.1 0.9 0.00096 19.2 0.3 3.9 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 CCF54502.1 - 8.6e-11 42.2 0.0 0.00055 20.1 0.0 2.6 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 CCF54502.1 - 2.3e-10 41.1 9.9 0.0023 18.4 0.0 5.2 4 2 0 5 5 5 2 AAA ATPase domain AAA_22 PF13401.6 CCF54502.1 - 6.2e-10 39.5 1.7 0.027 14.7 0.0 5.0 2 2 3 5 5 5 2 AAA domain TIP49 PF06068.13 CCF54502.1 - 5.3e-09 35.7 0.4 0.00026 20.3 0.1 2.9 2 1 1 3 3 3 2 TIP49 P-loop domain AAA_33 PF13671.6 CCF54502.1 - 5.8e-09 36.3 0.0 0.0023 18.1 0.0 2.6 2 0 0 2 2 2 2 AAA domain Mg_chelatase PF01078.21 CCF54502.1 - 4.5e-07 29.5 0.4 0.034 13.5 0.0 2.6 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_14 PF13173.6 CCF54502.1 - 8e-07 29.2 0.0 0.021 14.8 0.0 2.6 3 0 0 3 3 2 2 AAA domain RNA_helicase PF00910.22 CCF54502.1 - 1.8e-06 28.3 0.0 0.072 13.5 0.0 2.5 2 0 0 2 2 2 2 RNA helicase IstB_IS21 PF01695.17 CCF54502.1 - 4.5e-06 26.5 0.1 0.035 13.8 0.0 2.5 2 0 0 2 2 2 2 IstB-like ATP binding protein NACHT PF05729.12 CCF54502.1 - 5.4e-06 26.4 1.9 0.074 13.0 0.1 4.0 3 1 0 3 3 3 2 NACHT domain ABC_tran PF00005.27 CCF54502.1 - 1.1e-05 26.0 0.0 0.038 14.5 0.0 2.7 2 0 0 2 2 2 2 ABC transporter AAA_3 PF07726.11 CCF54502.1 - 1.9e-05 24.5 0.0 0.039 13.8 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.6 CCF54502.1 - 2.6e-05 24.5 0.0 0.32 11.2 0.0 2.5 2 0 0 2 2 2 2 AAA domain TsaE PF02367.17 CCF54502.1 - 2.8e-05 24.1 0.0 0.33 11.0 0.0 2.3 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE Cytidylate_kin2 PF13189.6 CCF54502.1 - 4.1e-05 23.8 0.0 0.018 15.1 0.0 2.4 2 0 0 2 2 2 1 Cytidylate kinase-like family AAA_18 PF13238.6 CCF54502.1 - 8.3e-05 23.1 0.0 0.41 11.2 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_25 PF13481.6 CCF54502.1 - 0.00011 21.9 2.2 0.83 9.2 0.2 3.8 3 1 1 4 4 4 2 AAA domain ATPase PF06745.13 CCF54502.1 - 0.00014 21.3 0.1 1.4 8.2 0.0 3.3 3 0 0 3 3 3 1 KaiC AAA_17 PF13207.6 CCF54502.1 - 0.00017 22.0 0.1 0.37 11.2 0.0 3.1 3 0 0 3 3 3 1 AAA domain Rad17 PF03215.15 CCF54502.1 - 0.0002 21.4 0.0 0.62 10.0 0.0 2.4 2 0 0 2 2 2 2 Rad17 P-loop domain Sigma54_activat PF00158.26 CCF54502.1 - 0.00024 20.8 0.0 0.45 10.2 0.0 3.5 4 0 0 4 4 4 1 Sigma-54 interaction domain AAA_7 PF12775.7 CCF54502.1 - 0.00031 20.3 0.0 0.55 9.7 0.0 2.7 2 1 0 2 2 2 2 P-loop containing dynein motor region Zeta_toxin PF06414.12 CCF54502.1 - 0.00035 19.9 0.2 0.66 9.2 0.0 2.6 2 0 0 2 2 2 2 Zeta toxin NB-ARC PF00931.22 CCF54502.1 - 0.00042 19.6 0.0 0.85 8.8 0.0 3.1 3 0 0 3 3 3 1 NB-ARC domain Viral_helicase1 PF01443.18 CCF54502.1 - 0.00054 19.8 0.0 1 9.1 0.0 2.4 2 0 0 2 2 2 2 Viral (Superfamily 1) RNA helicase AAA_11 PF13086.6 CCF54502.1 - 0.00062 19.6 0.0 0.78 9.5 0.0 2.5 2 0 0 2 2 2 2 AAA domain DUF815 PF05673.13 CCF54502.1 - 0.0013 18.0 0.0 0.025 13.7 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF815) Sigma54_activ_2 PF14532.6 CCF54502.1 - 0.0027 17.9 0.0 1.9 8.6 0.0 2.6 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_24 PF13479.6 CCF54502.1 - 0.0036 17.1 0.0 1.1 8.9 0.0 2.4 2 0 0 2 2 2 1 AAA domain AFG1_ATPase PF03969.16 CCF54502.1 - 0.0039 16.1 0.0 0.68 8.8 0.0 2.4 2 0 0 2 2 2 1 AFG1-like ATPase PhoH PF02562.16 CCF54502.1 - 0.0054 16.2 0.4 2.3 7.6 0.0 2.7 3 0 0 3 3 3 1 PhoH-like protein ATPase_2 PF01637.18 CCF54502.1 - 0.015 15.3 0.0 1.9 8.3 0.0 2.9 2 1 1 3 3 3 0 ATPase domain predominantly from Archaea TniB PF05621.11 CCF54502.1 - 0.017 14.5 0.0 20 4.5 0.0 3.4 3 0 0 3 3 3 0 Bacterial TniB protein Parvo_NS1 PF01057.17 CCF54502.1 - 0.02 14.0 0.0 1.9 7.5 0.0 2.2 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 SKI PF01202.22 CCF54502.1 - 0.021 15.0 0.1 6.2 6.9 0.0 2.6 2 0 0 2 2 2 0 Shikimate kinase Vps4_C PF09336.10 CCF54502.1 - 0.025 14.6 0.1 14 5.7 0.0 2.8 2 0 0 2 2 2 0 Vps4 C terminal oligomerisation domain NTPase_1 PF03266.15 CCF54502.1 - 0.05 13.5 0.1 8.9 6.2 0.0 2.5 2 0 0 2 2 2 0 NTPase AAA_19 PF13245.6 CCF54502.1 - 0.12 12.8 1.0 13 6.1 0.0 2.7 2 1 0 2 2 2 0 AAA domain PduV-EutP PF10662.9 CCF54502.1 - 0.14 11.9 0.0 9.7 5.9 0.0 2.5 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation ResIII PF04851.15 CCF54502.1 - 0.19 11.7 0.0 25 4.8 0.0 2.5 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit GLE1 PF07817.13 CCF54508.1 - 7e-78 261.3 0.1 1.1e-77 260.7 0.1 1.3 1 0 0 1 1 1 1 GLE1-like protein Sec7 PF01369.20 CCF54508.1 - 0.073 12.7 0.0 0.12 12.0 0.0 1.3 1 0 0 1 1 1 0 Sec7 domain OGG_N PF07934.12 CCF54509.1 - 1.4e-27 96.2 0.0 3e-27 95.1 0.0 1.6 1 0 0 1 1 1 1 8-oxoguanine DNA glycosylase, N-terminal domain HhH-GPD PF00730.25 CCF54509.1 - 1.5e-13 51.1 0.0 5.8e-13 49.2 0.0 2.0 1 1 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 CCF54509.1 - 0.00058 19.6 0.0 0.0015 18.3 0.0 1.7 1 0 0 1 1 1 1 Helix-hairpin-helix motif DUF1631 PF07793.11 CCF54509.1 - 0.042 12.3 0.4 0.058 11.8 0.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1631) DLIC PF05783.11 CCF54509.1 - 0.084 11.7 0.9 0.13 11.1 0.9 1.1 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) LZ_Tnp_IS66 PF13007.7 CCF54509.1 - 0.16 12.8 0.7 1.8 9.4 0.1 2.5 2 0 0 2 2 2 0 Transposase C of IS166 homeodomain NOB1_Zn_bind PF08772.11 CCF54510.1 - 1.3e-30 105.4 1.4 2.6e-30 104.4 1.4 1.6 1 0 0 1 1 1 1 Nin one binding (NOB1) Zn-ribbon like PIN_6 PF17146.4 CCF54510.1 - 4.5e-25 88.0 0.6 2.1e-24 85.8 0.0 2.3 2 0 0 2 2 2 1 PIN domain of ribonuclease DZR PF12773.7 CCF54510.1 - 0.11 12.5 2.1 0.2 11.7 2.1 1.4 1 0 0 1 1 1 0 Double zinc ribbon Borrelia_P83 PF05262.11 CCF54510.1 - 0.21 10.0 15.8 0.34 9.4 15.8 1.4 1 0 0 1 1 1 0 Borrelia P83/100 protein LAP1C PF05609.12 CCF54510.1 - 2 7.4 15.2 4.4 6.3 15.2 1.5 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) DUF4551 PF15087.6 CCF54510.1 - 3 6.5 6.8 5.8 5.6 6.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) YccV-like PF08755.11 CCF54511.1 - 4.2e-18 65.6 0.0 1.4e-17 64.0 0.0 1.9 1 0 0 1 1 1 1 Hemimethylated DNA-binding protein YccV like Transglut_core2 PF13369.6 CCF54511.1 - 3.7e-13 49.3 0.0 6.7e-12 45.2 0.0 2.5 2 0 0 2 2 2 1 Transglutaminase-like superfamily F-box-like PF12937.7 CCF54511.1 - 1.1e-08 34.8 0.1 3e-08 33.4 0.1 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 CCF54511.1 - 7.7e-06 25.7 0.0 2.5e-05 24.0 0.0 1.9 1 0 0 1 1 1 1 F-box domain F-box_4 PF15966.5 CCF54511.1 - 0.02 14.8 0.0 0.056 13.3 0.0 1.7 1 0 0 1 1 1 0 F-box CobU PF02283.16 CCF54511.1 - 0.11 12.0 0.4 0.31 10.6 0.4 1.7 1 0 0 1 1 1 0 Cobinamide kinase / cobinamide phosphate guanyltransferase AAA_28 PF13521.6 CCF54511.1 - 4.1 7.6 6.9 0.36 11.0 0.7 2.6 2 0 0 2 2 2 0 AAA domain WD40 PF00400.32 CCF54512.1 - 4e-12 46.4 6.7 0.0028 18.4 0.1 6.0 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCF54512.1 - 0.00011 22.4 0.0 0.075 13.3 0.0 2.8 2 0 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain PQQ_3 PF13570.6 CCF54512.1 - 0.0064 16.9 0.0 6.1 7.5 0.0 4.1 4 0 0 4 4 4 1 PQQ-like domain WD40_like PF17005.5 CCF54512.1 - 0.11 11.7 0.0 0.22 10.8 0.0 1.4 1 0 0 1 1 1 0 WD40-like domain zf-CCCH_4 PF18044.1 CCF54513.1 - 3.1e-09 36.4 2.5 5.8e-09 35.5 2.5 1.5 1 0 0 1 1 1 1 CCCH-type zinc finger zf_CCCH_4 PF18345.1 CCF54513.1 - 6.1e-06 26.1 6.5 1.2e-05 25.2 6.5 1.5 1 0 0 1 1 1 1 Zinc finger domain zf-CCCH PF00642.24 CCF54513.1 - 2e-05 24.4 1.3 3.6e-05 23.6 1.3 1.4 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.6 CCF54513.1 - 0.32 11.5 6.2 0.58 10.7 6.2 1.4 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger TIP41 PF04176.13 CCF54514.1 - 2.2e-44 151.0 0.0 1.3e-43 148.5 0.0 2.2 2 1 0 2 2 2 1 TIP41-like family Nop14 PF04147.12 CCF54515.1 - 0 1016.8 12.0 0 1016.5 12.0 1.0 1 0 0 1 1 1 1 Nop14-like family GRIM-19 PF06212.12 CCF54516.1 - 1.2e-34 119.1 0.0 1.3e-34 119.0 0.0 1.0 1 0 0 1 1 1 1 GRIM-19 protein Clathrin PF00637.20 CCF54517.1 - 3.2e-25 88.7 0.0 1.9e-24 86.2 0.0 2.3 2 0 0 2 2 2 1 Region in Clathrin and VPS Vps39_2 PF10367.9 CCF54517.1 - 0.15 12.5 0.0 0.52 10.8 0.0 2.0 2 1 0 2 2 2 0 Vacuolar sorting protein 39 domain 2 T2SSF PF00482.23 CCF54517.1 - 0.2 11.6 0.3 49 3.9 0.0 3.4 3 0 0 3 3 3 0 Type II secretion system (T2SS), protein F TPR_2 PF07719.17 CCF54517.1 - 0.2 11.8 0.8 3.5 8.0 0.2 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 CCF54517.1 - 0.36 11.8 4.7 12 7.1 0.1 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat TFIIA PF03153.13 CCF54517.1 - 4.4 7.2 27.4 3.2 7.7 25.1 1.8 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit PI3K_1B_p101 PF10486.9 CCF54517.1 - 8.8 4.0 6.4 16 3.1 6.4 1.3 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Cid2 PF09774.9 CCF54518.1 - 9.6e-37 126.9 0.1 9.6e-37 126.9 0.1 1.8 2 0 0 2 2 2 1 Caffeine-induced death protein 2 Chorion_2 PF03964.15 CCF54518.1 - 3 8.7 17.3 9 7.2 11.7 2.7 2 0 0 2 2 2 0 Chorion family 2 FAD-oxidase_C PF02913.19 CCF54519.1 - 8e-64 215.7 0.0 1.3e-63 215.0 0.0 1.3 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 CCF54519.1 - 8.2e-36 122.8 0.7 1.6e-35 121.9 0.7 1.5 1 0 0 1 1 1 1 FAD binding domain Ilar_coat PF01787.16 CCF54519.1 - 0.065 13.0 0.0 0.3 10.9 0.0 1.9 1 1 1 2 2 2 0 Ilarvirus coat protein Glyco_hydro_114 PF03537.13 CCF54519.1 - 0.082 12.2 0.0 0.15 11.4 0.0 1.4 1 0 0 1 1 1 0 Glycoside-hydrolase family GH114 Glyco_hydro_97 PF10566.9 CCF54519.1 - 0.14 11.4 0.0 0.23 10.7 0.0 1.2 1 0 0 1 1 1 0 Glycoside hydrolase 97 Metallophos PF00149.28 CCF54520.1 - 4.7e-39 135.0 0.2 6.4e-39 134.6 0.2 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 CCF54520.1 - 0.00093 19.6 0.5 0.0018 18.7 0.5 1.4 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain Metallophos_2 PF12850.7 CCF54520.1 - 0.16 12.2 0.0 0.24 11.6 0.0 1.3 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain Glyco_hydro_65N PF03636.15 CCF54520.1 - 0.19 11.4 0.0 0.27 10.8 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 65, N-terminal domain Clathrin_lg_ch PF01086.17 CCF54521.1 - 5.5e-41 141.1 24.6 1.1e-40 140.2 24.6 1.4 1 1 0 1 1 1 1 Clathrin light chain Ribosomal_S17_N PF16205.5 CCF54522.1 - 1e-30 105.9 1.6 1e-30 105.9 0.3 1.7 2 0 0 2 2 2 1 Ribosomal_S17 N-terminal Ribosomal_S17 PF00366.20 CCF54522.1 - 5.3e-28 96.9 1.6 8.7e-28 96.2 1.6 1.4 1 0 0 1 1 1 1 Ribosomal protein S17 Ribosomal_L7Ae PF01248.26 CCF54523.1 - 2.5e-28 97.6 0.8 3.2e-28 97.3 0.8 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family SAP18 PF06487.12 CCF54524.1 - 2.4e-27 95.8 0.0 3.1e-27 95.5 0.0 1.1 1 0 0 1 1 1 1 Sin3 associated polypeptide p18 (SAP18) Pkinase PF00069.25 CCF54525.1 - 1.2e-43 149.4 0.1 9.9e-22 77.5 0.0 3.6 4 0 0 4 4 4 3 Protein kinase domain Pkinase_Tyr PF07714.17 CCF54525.1 - 4.5e-12 45.8 0.1 6.9e-09 35.4 0.0 3.2 3 1 0 3 3 3 2 Protein tyrosine kinase Spt20 PF12090.8 CCF54525.1 - 0.018 14.7 14.5 0.036 13.7 14.5 1.5 1 0 0 1 1 1 0 Spt20 family Pex14_N PF04695.13 CCF54525.1 - 1.8 9.2 12.8 6.2 7.5 12.8 1.9 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region eIF-3_zeta PF05091.12 CCF54526.1 - 3.6e-203 676.3 0.0 4.1e-203 676.1 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) NARG2_C PF10505.9 CCF54526.1 - 0.21 11.1 0.0 5 6.6 0.0 2.1 2 0 0 2 2 2 0 NMDA receptor-regulated gene protein 2 C-terminus VID27 PF08553.10 CCF54527.1 - 3.9e-163 542.6 0.1 5.8e-163 542.0 0.1 1.2 1 0 0 1 1 1 1 VID27 C-terminal WD40-like domain VID27_N PF17748.1 CCF54527.1 - 1.3e-55 187.9 1.1 1.3e-55 187.9 1.1 2.6 3 0 0 3 3 3 1 VID27 N-terminal region VID27_PH PF17747.1 CCF54527.1 - 4.2e-32 110.7 4.5 4.2e-32 110.7 4.5 2.9 4 0 0 4 4 4 1 VID27 PH-like domain Isy1 PF06246.12 CCF54529.1 - 1.5e-89 300.0 7.8 3.5e-89 298.7 7.8 1.5 1 1 0 1 1 1 1 Isy1-like splicing family KIND PF16474.5 CCF54529.1 - 2.8 7.8 5.3 1.3 8.9 0.0 2.4 2 1 0 2 2 2 0 Kinase non-catalytic C-lobe domain Ribosomal_L18 PF17135.4 CCF54530.1 - 4.7e-89 296.8 2.0 5.2e-89 296.6 2.0 1.0 1 0 0 1 1 1 1 Ribosomal protein 60S L18 and 50S L18e Ribosomal_L27A PF00828.19 CCF54530.1 - 0.00052 20.7 0.9 0.0011 19.7 0.0 2.1 2 1 0 2 2 2 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A Adenylate_cycl PF01295.18 CCF54530.1 - 0.049 12.3 0.0 0.067 11.8 0.0 1.1 1 0 0 1 1 1 0 Adenylate cyclase, class-I RRM_1 PF00076.22 CCF54532.1 - 3.8e-15 55.5 0.0 5.3e-15 55.0 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 CCF54532.1 - 0.023 14.3 0.0 0.033 13.8 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) COesterase PF00135.28 CCF54533.1 - 1.2e-59 202.6 0.0 4.4e-59 200.7 0.0 1.9 1 1 0 1 1 1 1 Carboxylesterase family DnaJ PF00226.31 CCF54533.1 - 3.3e-12 46.3 0.8 1e-11 44.8 0.8 1.8 1 1 0 1 1 1 1 DnaJ domain zf-CSL PF05207.13 CCF54533.1 - 4.8e-09 35.8 0.2 1.2e-08 34.6 0.2 1.6 1 0 0 1 1 1 1 CSL zinc finger Abhydrolase_3 PF07859.13 CCF54533.1 - 8.5e-05 22.5 0.0 0.0012 18.7 0.0 2.3 2 0 0 2 2 2 1 alpha/beta hydrolase fold Iso_dh PF00180.20 CCF54534.1 - 1.5e-101 340.0 0.0 1.9e-101 339.7 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Polysacc_deac_1 PF01522.21 CCF54535.1 - 3.6e-19 68.9 0.0 8.7e-19 67.6 0.0 1.6 1 0 0 1 1 1 1 Polysaccharide deacetylase Collagen PF01391.18 CCF54535.1 - 0.021 14.6 5.1 0.04 13.7 5.1 1.4 1 0 0 1 1 1 0 Collagen triple helix repeat (20 copies) UPF0086 PF01868.16 CCF54536.1 - 2.1e-22 78.8 0.0 3.9e-22 78.0 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function UPF0086 Sec2p PF06428.11 CCF54536.1 - 0.29 11.1 4.2 2.1 8.4 4.2 2.3 1 1 0 1 1 1 0 GDP/GTP exchange factor Sec2p DUF4131 PF13567.6 CCF54537.1 - 0.003 17.2 10.9 0.0032 17.1 10.9 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4131) Pex24p PF06398.11 CCF54537.1 - 0.28 10.1 1.6 0.27 10.2 1.6 1.1 1 0 0 1 1 1 0 Integral peroxisomal membrane peroxin Wzy_C PF04932.15 CCF54537.1 - 0.49 10.0 4.8 0.48 10.0 4.8 1.2 1 0 0 1 1 1 0 O-Antigen ligase FA_desaturase PF00487.24 CCF54537.1 - 1.1 9.1 5.3 1.1 9.0 5.3 1.2 1 0 0 1 1 1 0 Fatty acid desaturase DUF4191 PF13829.6 CCF54537.1 - 1.7 7.9 4.3 1.6 8.0 4.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4191) YfhO PF09586.10 CCF54537.1 - 4.1 5.5 7.1 3.7 5.7 7.1 1.1 1 0 0 1 1 1 0 Bacterial membrane protein YfhO Velvet PF11754.8 CCF54538.1 - 2e-69 234.3 0.1 1.3e-68 231.7 0.0 1.9 2 0 0 2 2 2 1 Velvet factor COX6A PF02046.15 CCF54539.1 - 6.9e-37 126.3 1.8 8.5e-37 126.1 1.8 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIa Arm PF00514.23 CCF54540.1 - 4e-72 236.3 29.6 9.3e-12 44.6 0.1 11.7 12 0 0 12 12 11 10 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 CCF54540.1 - 1.7e-16 60.3 18.4 0.00026 21.4 0.4 8.7 6 3 3 9 9 9 5 HEAT-like repeat HEAT_2 PF13646.6 CCF54540.1 - 1.7e-14 53.9 13.0 0.0077 16.6 0.0 7.3 4 2 2 7 7 6 4 HEAT repeats Adaptin_N PF01602.20 CCF54540.1 - 5.4e-11 41.8 6.4 1.3e-07 30.6 0.1 2.9 1 1 1 2 2 2 2 Adaptin N terminal region Arm_2 PF04826.13 CCF54540.1 - 2.7e-10 40.1 4.3 2.4e-06 27.2 1.0 2.6 1 1 1 2 2 2 2 Armadillo-like HEAT PF02985.22 CCF54540.1 - 4.6e-10 38.9 23.9 0.83 10.1 0.0 10.6 12 0 0 12 12 11 4 HEAT repeat KAP PF05804.12 CCF54540.1 - 6.7e-10 37.8 0.1 1.4e-09 36.7 0.0 1.4 1 1 0 1 1 1 1 Kinesin-associated protein (KAP) V-ATPase_H_N PF03224.14 CCF54540.1 - 1.2e-09 37.9 3.3 0.0022 17.4 0.6 4.3 2 1 0 3 3 3 3 V-ATPase subunit H DUF3361 PF11841.8 CCF54540.1 - 2.3e-06 27.6 5.0 0.1 12.5 0.1 4.6 3 1 2 5 5 5 3 Domain of unknown function (DUF3361) Cnd1 PF12717.7 CCF54540.1 - 6.6e-05 23.0 5.4 0.15 12.1 0.1 4.0 2 2 3 5 5 5 4 non-SMC mitotic condensation complex subunit 1 IFRD PF05004.13 CCF54540.1 - 0.00028 20.1 2.1 1.1 8.3 0.1 4.2 3 1 1 4 4 4 1 Interferon-related developmental regulator (IFRD) V-ATPase_H_C PF11698.8 CCF54540.1 - 0.0006 19.9 1.5 33 4.6 0.0 5.4 3 1 3 6 6 6 0 V-ATPase subunit H HEAT_PBS PF03130.16 CCF54540.1 - 0.0074 16.9 7.4 1.1e+02 4.0 0.0 7.4 8 0 0 8 8 7 0 PBS lyase HEAT-like repeat YqfD PF06898.11 CCF54540.1 - 0.12 11.2 0.0 0.19 10.5 0.0 1.2 1 0 0 1 1 1 0 Putative stage IV sporulation protein YqfD Atx10homo_assoc PF09759.9 CCF54540.1 - 0.15 12.1 3.4 1.1 9.4 0.1 3.7 4 1 1 5 5 5 0 Spinocerebellar ataxia type 10 protein domain Sigma70_r3 PF04539.16 CCF54541.1 - 0.00069 19.7 1.2 0.0099 16.0 0.0 3.0 3 0 0 3 3 3 1 Sigma-70 region 3 zf-CCHC PF00098.23 CCF54542.1 - 0.0088 16.1 3.1 0.023 14.8 3.1 1.8 1 0 0 1 1 1 1 Zinc knuckle zf-ribbon_3 PF13248.6 CCF54542.1 - 0.042 13.3 1.6 0.12 11.8 1.5 1.9 2 0 0 2 2 2 0 zinc-ribbon domain PI31_Prot_N PF11566.8 CCF54542.1 - 0.13 12.0 0.0 0.31 10.8 0.0 1.6 1 0 0 1 1 1 0 PI31 proteasome regulator N-terminal zf-CCHC_6 PF15288.6 CCF54542.1 - 0.2 11.5 5.4 0.34 10.8 3.7 2.1 2 0 0 2 2 2 0 Zinc knuckle rve PF00665.26 CCF54543.1 - 8.4e-08 32.4 0.1 1.4e-07 31.7 0.1 1.4 1 0 0 1 1 1 1 Integrase core domain Glyoxal_oxid_N PF07250.11 CCF54544.1 - 2.2e-30 105.7 3.3 3.6e-28 98.4 1.9 3.7 3 1 0 3 3 3 1 Glyoxal oxidase N-terminus DUF1929 PF09118.11 CCF54544.1 - 2.1e-21 76.0 0.2 4e-21 75.1 0.2 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1929) Reg_prop PF07494.11 CCF54544.1 - 0.11 12.7 1.0 26 5.5 0.0 3.0 2 0 0 2 2 2 0 Two component regulator propeller RCC1_2 PF13540.6 CCF54544.1 - 0.12 12.3 0.6 0.89 9.4 0.0 2.8 3 0 0 3 3 3 0 Regulator of chromosome condensation (RCC1) repeat Nuc_N PF14448.6 CCF54544.1 - 0.14 12.0 0.1 1.3 8.9 0.0 2.3 2 0 0 2 2 2 0 Nuclease N terminal Kelch_4 PF13418.6 CCF54544.1 - 0.2 11.7 3.9 6.6 6.8 0.1 4.1 4 0 0 4 4 4 0 Galactose oxidase, central domain COX7a PF02238.15 CCF54545.1 - 5.3e-20 71.6 0.6 6.2e-20 71.4 0.6 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VII Maf PF02545.14 CCF54546.1 - 1.1e-44 152.2 0.0 1.3e-44 152.0 0.0 1.0 1 0 0 1 1 1 1 Maf-like protein DAO PF01266.24 CCF54547.1 - 2.8e-25 89.6 1.1 4.2e-25 89.1 1.1 1.3 1 1 0 1 1 1 1 FAD dependent oxidoreductase SMK-1 PF04802.15 CCF54548.1 - 7.2e-73 244.5 1.3 1.4e-72 243.5 1.3 1.5 1 0 0 1 1 1 1 Component of IIS longevity pathway SMK-1 DUF2610 PF11020.8 CCF54548.1 - 0.035 14.0 0.1 1.9 8.4 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF2610) RICTOR_N PF14664.6 CCF54548.1 - 0.15 11.0 0.7 0.31 10.0 0.7 1.4 1 0 0 1 1 1 0 Rapamycin-insensitive companion of mTOR, N-term WD40 PF00400.32 CCF54549.1 - 4.5e-36 122.2 30.5 0.0037 18.1 0.0 12.1 11 1 0 11 11 11 10 WD domain, G-beta repeat Utp12 PF04003.12 CCF54549.1 - 2.2e-20 72.9 1.0 4.5e-20 71.9 1.0 1.5 1 0 0 1 1 1 1 Dip2/Utp12 Family ANAPC4_WD40 PF12894.7 CCF54549.1 - 4.9e-19 68.4 0.6 0.001 19.3 0.0 7.1 5 3 1 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 CCF54549.1 - 2.6e-09 36.3 0.6 0.02 13.5 0.0 5.5 5 1 1 6 6 6 4 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 CCF54549.1 - 1.5e-05 24.1 0.1 2.3 7.1 0.0 5.1 5 1 0 5 5 5 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Utp21 PF04192.12 CCF54549.1 - 0.048 13.2 0.0 0.048 13.2 0.0 1.6 2 0 0 2 2 2 0 Utp21 specific WD40 associated putative domain PALB2_WD40 PF16756.5 CCF54549.1 - 0.053 12.4 3.9 4.5 6.1 0.2 3.1 4 0 0 4 4 4 0 Partner and localizer of BRCA2 WD40 domain Cytochrom_D1 PF02239.16 CCF54549.1 - 0.061 11.8 0.0 0.26 9.8 0.0 2.0 2 0 0 2 2 2 0 Cytochrome D1 heme domain Glyco_transf_15 PF01793.16 CCF54551.1 - 1.2e-116 389.6 6.6 1.5e-116 389.2 6.6 1.1 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase 2OG-FeII_Oxy PF03171.20 CCF54552.1 - 5.3e-18 65.4 0.0 1.2e-17 64.3 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.6 CCF54552.1 - 3.4e-16 60.1 0.0 8.1e-16 58.8 0.0 1.6 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal DUF3419 PF11899.8 CCF54553.1 - 6.3e-145 483.2 0.2 8.7e-145 482.7 0.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3419) Methyltransf_25 PF13649.6 CCF54553.1 - 4.2e-09 37.0 0.0 2.2e-08 34.7 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF54553.1 - 1.8e-08 34.3 0.0 4.7e-08 33.0 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF54553.1 - 7.4e-08 32.9 0.0 4.7e-06 27.2 0.0 2.8 3 0 0 3 3 3 1 Methyltransferase domain Ubie_methyltran PF01209.18 CCF54553.1 - 4.6e-07 29.4 0.0 2.4e-05 23.8 0.0 2.2 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.6 CCF54553.1 - 2.3e-06 27.5 0.0 5e-06 26.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF54553.1 - 5.7e-05 23.8 0.0 0.00012 22.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 CCF54553.1 - 0.0087 15.5 0.0 0.017 14.6 0.0 1.4 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_2 PF00891.18 CCF54553.1 - 0.049 12.9 0.0 0.1 11.9 0.0 1.4 1 0 0 1 1 1 0 O-methyltransferase domain SRP68 PF16969.5 CCF54554.1 - 3.5e-49 168.3 48.5 3.2e-41 142.0 15.9 3.3 1 1 1 2 2 2 2 RNA-binding signal recognition particle 68 TPR_19 PF14559.6 CCF54554.1 - 0.018 15.6 6.8 0.08 13.5 1.3 3.6 2 0 0 2 2 2 0 Tetratricopeptide repeat RVT_1 PF00078.27 CCF54555.1 - 5e-32 111.2 0.0 8.6e-32 110.4 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Cellulase PF00150.18 CCF54557.1 - 5.9e-13 48.9 14.4 2.1e-12 47.1 14.4 1.8 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Albumin_I_a PF16720.5 CCF54557.1 - 0.32 10.9 1.4 0.63 10.0 1.4 1.4 1 0 0 1 1 1 0 Albumin I chain a ATG_C PF09333.11 CCF54558.1 - 9.4e-30 102.8 0.2 3.2e-29 101.1 0.2 2.0 1 0 0 1 1 1 1 Autophagy-related protein C terminal domain Chorein_N PF12624.7 CCF54558.1 - 1.2e-13 51.2 0.0 4.1e-13 49.5 0.0 1.9 1 0 0 1 1 1 1 N-terminal region of Chorein or VPS13 ATG2_CAD PF13329.6 CCF54558.1 - 9.1e-12 45.0 0.0 2.5e-11 43.5 0.0 1.8 1 0 0 1 1 1 1 Autophagy-related protein 2 CAD motif VPS13_C PF16909.5 CCF54558.1 - 0.018 14.8 0.0 0.045 13.5 0.0 1.6 1 0 0 1 1 1 0 Vacuolar-sorting-associated 13 protein C-terminal RabGAP-TBC PF00566.18 CCF54560.1 - 1.5e-26 93.4 0.0 2.2e-22 79.8 0.0 2.8 2 1 0 2 2 2 2 Rab-GTPase-TBC domain TpcC PF12642.7 CCF54560.1 - 0.56 10.0 1.9 1.7 8.3 0.1 2.1 1 1 1 2 2 2 0 Conjugative transposon protein TcpC FAD_binding_2 PF00890.24 CCF54561.1 - 1.3e-126 423.1 3.3 2e-126 422.5 3.3 1.3 1 0 0 1 1 1 1 FAD binding domain Succ_DH_flav_C PF02910.20 CCF54561.1 - 3.6e-42 143.4 0.4 5.5e-42 142.8 0.4 1.3 1 0 0 1 1 1 1 Fumarate reductase flavoprotein C-term GIDA PF01134.22 CCF54561.1 - 1.5e-05 24.3 1.1 0.037 13.1 1.9 2.4 2 0 0 2 2 2 2 Glucose inhibited division protein A Thi4 PF01946.17 CCF54561.1 - 4.2e-05 22.9 0.5 0.012 14.9 0.1 2.4 2 0 0 2 2 2 2 Thi4 family Pyr_redox_2 PF07992.14 CCF54561.1 - 0.0014 17.9 0.8 0.022 14.0 0.3 2.7 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 CCF54561.1 - 0.0054 16.0 0.2 0.011 15.0 0.2 1.5 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 CCF54561.1 - 0.16 10.6 2.5 0.7 8.5 0.5 2.7 3 0 0 3 3 3 0 HI0933-like protein DAO PF01266.24 CCF54561.1 - 0.22 11.0 5.3 0.21 11.1 1.5 2.6 2 1 0 2 2 2 0 FAD dependent oxidoreductase KTI12 PF08433.10 CCF54562.1 - 3.5e-56 190.6 0.0 5.7e-56 190.0 0.0 1.3 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_33 PF13671.6 CCF54562.1 - 1.7e-05 25.0 0.0 3.2e-05 24.1 0.0 1.6 1 1 0 1 1 1 1 AAA domain DEAD PF00270.29 CCF54563.1 - 1e-51 175.2 0.0 2.6e-50 170.6 0.0 2.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CCF54563.1 - 5.2e-27 94.4 0.3 7.1e-26 90.7 0.0 2.9 4 0 0 4 4 4 1 Helicase conserved C-terminal domain ResIII PF04851.15 CCF54563.1 - 0.00058 19.9 0.0 0.0034 17.4 0.0 2.3 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit TFIIA PF03153.13 CCF54563.1 - 0.57 10.1 25.2 0.12 12.3 10.5 2.3 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit PAP_assoc PF03828.19 CCF54564.1 - 4.7e-21 74.7 0.0 1.3e-20 73.3 0.0 1.8 1 0 0 1 1 1 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.23 CCF54564.1 - 2.7e-09 37.2 0.0 5.2e-09 36.3 0.0 1.4 1 0 0 1 1 1 1 Nucleotidyltransferase domain DUF3602 PF12223.8 CCF54564.1 - 9.9 6.8 8.2 8.6 7.0 1.8 3.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3602) tRNA-synt_2d PF01409.20 CCF54566.1 - 3e-48 164.4 1.1 3.2e-26 92.3 0.0 3.9 3 1 0 3 3 3 2 tRNA synthetases class II core domain (F) FDX-ACB PF03147.14 CCF54566.1 - 3.2e-24 85.2 0.1 8.5e-24 83.8 0.1 1.8 1 0 0 1 1 1 1 Ferredoxin-fold anticodon binding domain DOCK_N PF16172.5 CCF54567.1 - 1.5e-109 366.4 0.0 2.4e-109 365.8 0.0 1.3 1 0 0 1 1 1 1 DOCK N-terminus DHR-2 PF06920.13 CCF54567.1 - 1.3e-77 261.7 0.1 2.8e-77 260.6 0.1 1.6 1 0 0 1 1 1 1 Dock homology region 2 DOCK-C2 PF14429.6 CCF54567.1 - 9.3e-52 175.7 0.0 5.7e-51 173.1 0.0 2.1 2 0 0 2 2 2 1 C2 domain in Dock180 and Zizimin proteins Aida_C2 PF14186.6 CCF54567.1 - 0.17 11.5 0.0 0.35 10.5 0.0 1.4 1 0 0 1 1 1 0 Cytoskeletal adhesion Sugar_tr PF00083.24 CCF54569.1 - 1.8e-101 340.2 14.8 4.2e-56 190.7 2.3 2.0 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 CCF54569.1 - 2.4e-28 99.1 21.3 2.4e-28 99.1 21.3 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 CCF54569.1 - 0.00083 17.9 2.6 0.0015 17.1 2.6 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MCPsignal PF00015.21 CCF54569.1 - 0.073 12.9 0.8 0.13 12.1 0.8 1.2 1 0 0 1 1 1 0 Methyl-accepting chemotaxis protein (MCP) signalling domain Phage_holin_3_2 PF04550.12 CCF54569.1 - 0.08 13.5 11.6 0.059 13.9 5.2 3.2 3 1 0 3 3 3 0 Phage holin family 2 SNARE_assoc PF09335.11 CCF54570.1 - 2.3e-11 44.2 2.4 2.3e-11 44.2 2.4 2.9 3 1 0 3 3 3 1 SNARE associated Golgi protein DUF3082 PF11282.8 CCF54570.1 - 0.031 14.5 3.4 0.92 9.8 0.1 3.6 4 0 0 4 4 4 0 Protein of unknown function (DUF3082) Sld5 PF05916.11 CCF54571.1 - 2.1e-19 70.0 0.0 3.1e-19 69.4 0.0 1.2 1 0 0 1 1 1 1 GINS complex protein RhoGAP PF00620.27 CCF54572.1 - 2.7e-40 137.7 0.0 6.6e-40 136.4 0.0 1.7 1 0 0 1 1 1 1 RhoGAP domain RasGEF PF00617.19 CCF54572.1 - 6.5e-14 52.5 0.0 4e-13 50.0 0.0 2.4 3 0 0 3 3 3 1 RasGEF domain RasGEF_N PF00618.20 CCF54572.1 - 4.4e-12 46.2 1.4 1.8e-11 44.2 0.0 2.9 2 1 0 2 2 2 1 RasGEF N-terminal motif PH_9 PF15410.6 CCF54572.1 - 2.1e-06 28.1 0.0 5.8e-05 23.4 0.0 2.7 2 0 0 2 2 2 1 Pleckstrin homology domain PH PF00169.29 CCF54572.1 - 4e-05 24.1 0.0 0.13 12.7 0.0 2.7 2 0 0 2 2 2 2 PH domain Trypan_PARP PF05887.11 CCF54572.1 - 0.0012 18.8 4.2 0.0012 18.8 4.2 2.0 2 0 0 2 2 2 1 Procyclic acidic repetitive protein (PARP) TPR_5 PF12688.7 CCF54572.1 - 0.12 12.6 1.4 0.29 11.4 0.2 2.3 2 0 0 2 2 2 0 Tetratrico peptide repeat Spt20 PF12090.8 CCF54572.1 - 7.3 6.1 43.5 0.13 11.9 11.8 2.7 2 0 0 2 2 2 0 Spt20 family AMP-binding PF00501.28 CCF54573.1 - 6.2e-91 305.1 0.0 8.5e-91 304.6 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 CCF54573.1 - 6.6e-15 55.9 0.6 1.5e-14 54.7 0.6 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain AAA_11 PF13086.6 CCF54574.1 - 9.4e-71 238.7 2.7 1.4e-70 238.0 2.7 1.3 1 0 0 1 1 1 1 AAA domain AAA_12 PF13087.6 CCF54574.1 - 2.5e-60 203.5 0.0 4.3e-60 202.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 CCF54574.1 - 7.5e-10 39.3 0.1 3.5e-09 37.2 0.1 2.1 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 CCF54574.1 - 1.9e-08 34.3 4.2 2.5e-05 24.1 0.3 3.1 2 1 1 3 3 3 2 AAA domain Viral_helicase1 PF01443.18 CCF54574.1 - 2.5e-06 27.4 0.5 0.067 12.9 0.0 3.2 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase UvrD-helicase PF00580.21 CCF54574.1 - 0.00043 19.9 1.7 0.088 12.3 1.7 2.5 1 1 0 1 1 1 1 UvrD/REP helicase N-terminal domain DEAD PF00270.29 CCF54574.1 - 0.00048 19.9 0.9 0.072 12.9 0.1 2.4 1 1 0 2 2 2 1 DEAD/DEAH box helicase AAA_23 PF13476.6 CCF54574.1 - 0.002 18.7 0.3 0.0048 17.4 0.3 1.6 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 CCF54574.1 - 0.0039 17.5 0.8 1.1 9.5 0.1 3.0 3 0 0 3 3 3 1 AAA domain Helicase_RecD PF05127.14 CCF54574.1 - 0.013 15.3 3.9 0.16 11.8 0.0 3.1 1 1 1 2 2 2 0 Helicase Cep57_MT_bd PF06657.13 CCF54574.1 - 0.033 14.6 2.6 0.086 13.3 2.6 1.7 1 0 0 1 1 1 0 Centrosome microtubule-binding domain of Cep57 Annexin PF00191.20 CCF54574.1 - 0.04 14.0 0.2 0.66 10.1 0.0 2.4 2 0 0 2 2 2 0 Annexin GreA_GreB_N PF03449.15 CCF54574.1 - 0.059 13.5 0.2 0.059 13.5 0.2 2.1 2 0 0 2 2 2 0 Transcription elongation factor, N-terminal AAA PF00004.29 CCF54574.1 - 0.1 13.0 0.6 0.33 11.4 0.1 2.1 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Atg14 PF10186.9 CCF54574.1 - 0.37 9.8 3.5 0.57 9.2 3.5 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Seryl_tRNA_N PF02403.22 CCF54574.1 - 2.8 8.2 7.8 1.8 8.9 5.0 2.1 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain DUF1192 PF06698.11 CCF54574.1 - 4.3 7.5 6.2 3.8 7.7 0.7 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1192) SnoaL PF07366.12 CCF54575.1 - 0.018 14.9 0.0 0.027 14.3 0.0 1.3 1 0 0 1 1 1 0 SnoaL-like polyketide cyclase CDC50 PF03381.15 CCF54576.1 - 4.9e-91 305.1 0.2 6e-91 304.8 0.2 1.1 1 0 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family CEND1 PF15677.5 CCF54576.1 - 2.2 8.8 4.2 0.65 10.5 0.3 1.9 2 0 0 2 2 2 0 Cell cycle exit and neuronal differentiation protein 1 Sec7 PF01369.20 CCF54577.1 - 9.5e-65 217.7 0.0 1.7e-64 216.9 0.0 1.4 1 0 0 1 1 1 1 Sec7 domain Sec7_N PF12783.7 CCF54577.1 - 8.1e-17 61.6 0.0 1.1e-15 57.9 0.0 2.9 3 0 0 3 3 3 1 Guanine nucleotide exchange factor in Golgi transport N-terminal Spt20 PF12090.8 CCF54577.1 - 0.01 15.4 22.5 0.18 11.4 0.9 2.4 2 0 0 2 2 2 0 Spt20 family Med24_N PF11277.8 CCF54577.1 - 0.062 11.4 2.8 0.11 10.5 2.8 1.3 1 0 0 1 1 1 0 Mediator complex subunit 24 N-terminal DDHD PF02862.17 CCF54577.1 - 0.33 11.1 6.6 2.7 8.1 1.4 2.6 2 0 0 2 2 2 0 DDHD domain AAR2 PF05282.11 CCF54578.1 - 5.1e-79 266.2 0.3 5.9e-79 266.0 0.3 1.0 1 0 0 1 1 1 1 AAR2 protein Pkinase PF00069.25 CCF54581.1 - 1.1e-62 211.8 0.0 1.4e-62 211.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF54581.1 - 3e-19 69.3 0.0 4.1e-19 68.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 CCF54581.1 - 2.9e-07 30.7 0.0 3.7e-06 27.0 0.1 2.3 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 CCF54581.1 - 0.013 14.9 0.0 0.022 14.1 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 CCF54581.1 - 0.013 14.3 0.0 0.02 13.7 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase Choline_kinase PF01633.20 CCF54581.1 - 0.048 13.2 0.2 0.048 13.2 0.2 1.6 2 0 0 2 2 2 0 Choline/ethanolamine kinase DUF2456 PF10445.9 CCF54582.1 - 8e-18 64.3 9.8 8e-18 64.3 9.8 1.9 2 1 0 2 2 2 1 Protein of unknown function (DUF2456) RRM_1 PF00076.22 CCF54583.1 - 6.6e-44 147.6 0.0 8e-19 67.2 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 CCF54583.1 - 9.4e-07 28.5 0.0 0.0026 17.4 0.0 2.4 1 1 1 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SNF2_N PF00176.23 CCF54584.1 - 3.4e-73 246.4 1.2 6.9e-73 245.4 1.2 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 CCF54584.1 - 6.7e-21 74.7 0.2 7.2e-19 68.2 0.0 3.4 3 0 0 3 3 3 1 Helicase conserved C-terminal domain HSA PF07529.13 CCF54584.1 - 3.1e-20 72.3 7.7 3.1e-20 72.3 7.7 4.1 4 0 0 4 4 4 1 HSA Bromodomain PF00439.25 CCF54584.1 - 2.9e-15 56.1 0.0 7.1e-15 54.8 0.0 1.7 1 0 0 1 1 1 1 Bromodomain QLQ PF08880.11 CCF54584.1 - 3.1e-13 49.2 1.0 9e-13 47.7 1.0 1.8 1 0 0 1 1 1 1 QLQ SnAC PF14619.6 CCF54584.1 - 3.2e-13 50.1 0.4 3.2e-13 50.1 0.4 4.0 4 0 0 4 4 4 1 Snf2-ATP coupling, chromatin remodelling complex ResIII PF04851.15 CCF54584.1 - 1e-11 45.2 0.1 4e-11 43.2 0.1 2.1 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit SWI2_SNF2 PF18766.1 CCF54584.1 - 3.5e-05 23.6 0.1 0.00011 21.9 0.1 1.8 1 0 0 1 1 1 1 SWI2/SNF2 ATPase RNA_pol_L_2 PF13656.6 CCF54585.1 - 1.6e-29 101.5 0.0 2.1e-29 101.1 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.24 CCF54585.1 - 1.7e-11 43.4 0.0 2.4e-11 42.9 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain DUF1682 PF07946.14 CCF54585.1 - 0.0042 16.3 0.1 0.0052 16.0 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1682) B12-binding_2 PF02607.17 CCF54585.1 - 3 8.3 5.3 41 4.7 0.1 2.2 2 0 0 2 2 2 0 B12 binding domain TFIIS_M PF07500.14 CCF54586.1 - 2.8e-22 79.3 0.5 3.9e-22 78.9 0.5 1.2 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS), central domain DUF218 PF02698.17 CCF54587.1 - 0.00027 21.0 0.0 0.68 9.9 0.0 2.2 1 1 1 2 2 2 2 DUF218 domain Usp PF00582.26 CCF54588.1 - 1.1e-20 74.6 0.1 1.6e-20 74.0 0.1 1.2 1 0 0 1 1 1 1 Universal stress protein family Toprim_4 PF13662.6 CCF54588.1 - 0.002 18.5 0.1 0.048 14.1 0.0 2.3 2 0 0 2 2 2 1 Toprim domain PriA_C PF18074.1 CCF54588.1 - 0.1 13.4 0.0 0.19 12.6 0.0 1.4 1 0 0 1 1 1 0 Primosomal protein N C-terminal domain Phage_DsbA PF11126.8 CCF54588.1 - 0.14 12.3 0.0 0.25 11.6 0.0 1.3 1 0 0 1 1 1 0 Transcriptional regulator DsbA ING PF12998.7 CCF54589.1 - 5.1e-09 36.6 0.0 8.8e-09 35.9 0.0 1.3 1 0 0 1 1 1 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.29 CCF54589.1 - 1.6e-05 24.7 6.8 2.5e-05 24.1 6.8 1.3 1 0 0 1 1 1 1 PHD-finger zf-HC5HC2H PF13771.6 CCF54589.1 - 0.1 12.8 0.1 0.21 11.8 0.1 1.4 1 0 0 1 1 1 0 PHD-like zinc-binding domain PHD_2 PF13831.6 CCF54589.1 - 0.32 10.6 2.6 0.55 9.8 2.6 1.3 1 0 0 1 1 1 0 PHD-finger EF1_GNE PF00736.19 CCF54590.1 - 2.2e-30 104.7 0.5 2.2e-30 104.7 0.5 1.7 2 0 0 2 2 2 1 EF-1 guanine nucleotide exchange domain EF-1_beta_acid PF10587.9 CCF54590.1 - 2e-13 50.5 3.6 2e-13 50.5 3.6 2.6 2 0 0 2 2 2 1 Eukaryotic elongation factor 1 beta central acidic region GST_C_2 PF13410.6 CCF54590.1 - 0.0005 20.0 0.3 0.0031 17.5 0.3 2.2 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 CCF54590.1 - 0.0036 17.5 0.2 0.01 16.0 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain Cwf_Cwc_15 PF04889.12 CCF54590.1 - 0.031 14.0 0.3 0.042 13.6 0.3 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Sorting_nexin PF03700.13 CCF54590.1 - 0.058 14.0 1.2 0.11 13.1 1.2 1.4 1 0 0 1 1 1 0 Sorting nexin, N-terminal domain GST_C PF00043.25 CCF54590.1 - 0.061 13.6 0.4 0.23 11.7 0.0 2.1 2 1 0 2 2 2 0 Glutathione S-transferase, C-terminal domain GST_C_6 PF17171.4 CCF54590.1 - 0.11 12.3 0.0 0.2 11.5 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain DNA_ligase_A_M PF01068.21 CCF54591.1 - 6.2e-07 29.3 0.0 3.1e-06 27.0 0.0 2.0 1 1 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_OB_2 PF14743.6 CCF54591.1 - 3.8e-06 26.8 0.0 1.4e-05 25.0 0.0 1.9 2 0 0 2 2 2 1 DNA ligase OB-like domain FMN_dh PF01070.18 CCF54591.1 - 0.086 11.9 0.0 0.14 11.1 0.0 1.3 1 0 0 1 1 1 0 FMN-dependent dehydrogenase DUF1153 PF06627.11 CCF54591.1 - 0.11 12.6 0.0 1.4 9.1 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1153) ORC5_C PF14630.6 CCF54592.1 - 2.4e-78 263.6 0.3 3.9e-78 262.9 0.3 1.3 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 5 C-terminus DUF3292 PF11696.8 CCF54593.1 - 3.3e-226 752.7 0.3 1.8e-137 459.5 0.0 2.8 1 1 2 3 3 3 2 Protein of unknown function (DUF3292) Glucos_trans_II PF14264.6 CCF54593.1 - 0.24 10.7 2.0 0.57 9.5 0.2 2.0 2 0 0 2 2 2 0 Glucosyl transferase GtrII Nop14 PF04147.12 CCF54593.1 - 1.2 7.3 6.6 1.8 6.6 6.6 1.2 1 0 0 1 1 1 0 Nop14-like family Trypsin_2 PF13365.6 CCF54595.1 - 1.1e-06 29.7 3.9 0.059 14.3 0.0 2.6 1 1 0 2 2 2 2 Trypsin-like peptidase domain MRP-L20 PF12824.7 CCF54596.1 - 1.4e-28 100.1 5.8 2.5e-28 99.3 5.8 1.4 1 0 0 1 1 1 1 Mitochondrial ribosomal protein subunit L20 Pyr_redox_2 PF07992.14 CCF54596.1 - 3.4e-11 42.9 0.0 6e-09 35.5 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CCF54596.1 - 0.014 15.4 0.0 0.29 11.1 0.0 2.2 2 0 0 2 2 2 0 FAD-NAD(P)-binding DAO PF01266.24 CCF54596.1 - 0.035 13.7 0.2 0.059 13.0 0.2 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase Sacchrp_dh_NADP PF03435.18 CCF54596.1 - 0.19 12.0 0.1 0.39 11.0 0.1 1.5 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Lycopene_cycl PF05834.12 CCF54596.1 - 0.22 10.5 0.0 0.31 10.0 0.0 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein DUF3818 PF12825.7 CCF54597.1 - 5.7e-133 443.1 0.1 7.9e-133 442.7 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function in PX-proteins (DUF3818) PXB PF12828.7 CCF54597.1 - 9.3e-42 142.1 1.6 2.2e-41 140.9 1.6 1.7 1 0 0 1 1 1 1 PX-associated PX PF00787.24 CCF54597.1 - 5.1e-09 36.1 0.0 3.2e-08 33.6 0.0 2.5 2 1 0 2 2 2 1 PX domain TetR_C_26 PF17934.1 CCF54597.1 - 0.015 15.7 0.0 0.031 14.6 0.0 1.5 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain CPSF100_C PF13299.6 CCF54597.1 - 0.026 14.7 1.2 0.078 13.2 1.2 1.8 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DNA_pol_phi PF04931.13 CCF54597.1 - 2.7 6.0 10.2 2.5 6.1 8.3 1.8 2 0 0 2 2 2 0 DNA polymerase phi Aminotran_1_2 PF00155.21 CCF54598.1 - 7.5e-33 114.2 0.0 1.1e-32 113.7 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II DeoC PF01791.9 CCF54599.1 - 2.1e-21 76.7 1.9 2.8e-21 76.2 1.9 1.1 1 0 0 1 1 1 1 DeoC/LacD family aldolase His_biosynth PF00977.21 CCF54599.1 - 0.013 15.0 1.2 0.048 13.1 0.1 2.3 2 1 1 3 3 3 0 Histidine biosynthesis protein TPR_12 PF13424.6 CCF54600.1 - 0.00042 20.5 0.4 6.3 7.2 0.0 4.5 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_2 PF07719.17 CCF54600.1 - 0.0024 17.9 3.2 5 7.5 0.1 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_10 PF13374.6 CCF54600.1 - 0.0025 17.6 1.1 0.36 10.8 0.0 4.3 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_14 PF13428.6 CCF54600.1 - 0.011 16.5 2.3 11 7.2 0.1 3.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.6 CCF54600.1 - 0.015 15.3 0.2 0.45 10.7 0.1 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.6 CCF54600.1 - 0.017 15.3 1.6 3.8 8.0 0.0 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.28 CCF54600.1 - 0.051 13.4 0.2 17 5.4 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat MOZ_SAS PF01853.18 CCF54601.1 - 4.2e-60 202.5 0.2 4.6e-58 195.8 0.0 2.1 2 0 0 2 2 2 2 MOZ/SAS family zf-MYST PF17772.1 CCF54601.1 - 1.8e-15 56.3 2.5 2.3e-07 30.3 0.0 2.4 2 0 0 2 2 2 2 MYST family zinc finger domain Tudor-knot PF11717.8 CCF54601.1 - 4.8e-12 45.6 0.0 9.6e-12 44.6 0.0 1.5 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Agenet PF05641.12 CCF54601.1 - 0.021 15.3 0.0 0.056 13.9 0.0 1.8 1 0 0 1 1 1 0 Agenet domain Methyltransf_11 PF08241.12 CCF54602.1 - 4.4e-13 49.7 0.0 1.1e-12 48.4 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF54602.1 - 7.2e-13 49.1 0.0 2.1e-12 47.6 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF54602.1 - 2.3e-10 41.1 0.0 4.8e-10 40.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCF54602.1 - 5.8e-10 39.2 0.0 1.8e-09 37.7 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain DUF938 PF06080.12 CCF54602.1 - 6.1e-07 29.4 0.0 9.6e-07 28.8 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF938) Methyltransf_31 PF13847.6 CCF54602.1 - 2.2e-05 24.3 0.0 9.2e-05 22.3 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_16 PF10294.9 CCF54602.1 - 0.089 12.5 0.0 0.19 11.5 0.0 1.5 1 1 0 1 1 1 0 Lysine methyltransferase MTS PF05175.14 CCF54602.1 - 0.091 12.3 0.0 0.42 10.1 0.0 2.0 1 1 0 1 1 1 0 Methyltransferase small domain DREV PF05219.12 CCF54602.1 - 0.1 11.7 0.0 0.16 11.1 0.0 1.2 1 0 0 1 1 1 0 DREV methyltransferase tRNA_U5-meth_tr PF05958.11 CCF54602.1 - 0.2 10.6 0.0 0.33 9.9 0.0 1.3 1 0 0 1 1 1 0 tRNA (Uracil-5-)-methyltransferase CAP PF00188.26 CCF54603.1 - 3.2e-24 86.2 3.3 3.2e-24 86.2 3.3 2.4 2 1 1 3 3 3 1 Cysteine-rich secretory protein family Collagen PF01391.18 CCF54603.1 - 0.45 10.3 9.1 1.3 8.9 9.1 1.8 1 0 0 1 1 1 0 Collagen triple helix repeat (20 copies) TAF4 PF05236.14 CCF54603.1 - 0.74 9.5 12.4 1 9.0 12.4 1.2 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family E1-E2_ATPase PF00122.20 CCF54604.1 - 1.7e-48 164.6 1.6 4.3e-48 163.2 0.0 2.5 3 0 0 3 3 3 1 E1-E2 ATPase Hydrolase PF00702.26 CCF54604.1 - 5.7e-19 69.2 2.8 2.1e-18 67.4 2.8 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 CCF54604.1 - 1.4e-11 43.9 0.0 3.3e-11 42.7 0.0 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 CCF54604.1 - 0.00053 19.8 0.1 0.002 17.9 0.1 1.9 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase TMEM132D_C PF15706.5 CCF54604.1 - 0.0053 16.5 1.0 1.5 8.7 0.0 3.1 3 0 0 3 3 3 1 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term Cation_ATPase PF13246.6 CCF54604.1 - 0.19 11.9 0.0 0.43 10.7 0.0 1.6 1 0 0 1 1 1 0 Cation transport ATPase (P-type) DUF1977 PF09320.11 CCF54606.1 - 5.7e-25 87.6 0.3 9.6e-25 86.9 0.3 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1977) DnaJ PF00226.31 CCF54606.1 - 6.4e-24 83.9 0.1 1.3e-23 82.9 0.1 1.5 1 0 0 1 1 1 1 DnaJ domain Apc15p PF05841.11 CCF54606.1 - 0.27 12.0 1.5 0.98 10.2 0.1 2.2 2 0 0 2 2 2 0 Apc15p protein DUF3446 PF11928.8 CCF54606.1 - 3.3 8.1 11.6 6.2 7.2 9.4 2.3 2 0 0 2 2 2 0 Early growth response N-terminal domain gag_pre-integrs PF13976.6 CCF54608.1 - 3.3e-09 36.5 0.3 6.7e-09 35.5 0.3 1.5 1 0 0 1 1 1 1 GAG-pre-integrase domain Integrase_H2C2 PF17921.1 CCF54608.1 - 0.11 12.7 1.5 1.1 9.4 0.0 2.4 2 0 0 2 2 2 0 Integrase zinc binding domain RVT_2 PF07727.14 CCF54609.1 - 7.4e-16 58.5 0.0 1e-15 58.1 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Mustang PF15682.5 CCF54609.1 - 0.12 12.5 0.2 0.23 11.6 0.2 1.5 1 0 0 1 1 1 0 Musculoskeletal, temporally activated-embryonic nuclear protein 1 RVT_2 PF07727.14 CCF54610.1 - 1.3e-14 54.4 0.0 1.6e-14 54.1 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) UQ_con PF00179.26 CCF54611.1 - 2.5e-50 169.8 0.0 2.9e-50 169.6 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 CCF54611.1 - 0.00088 19.0 0.0 0.0016 18.2 0.0 1.3 1 1 0 1 1 1 1 Prokaryotic E2 family B HSP70 PF00012.20 CCF54612.1 - 7.2e-261 866.6 8.6 8.2e-261 866.4 8.6 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 CCF54612.1 - 3.4e-12 45.8 8.7 1.5e-11 43.7 1.2 2.8 3 0 0 3 3 3 2 MreB/Mbl protein FtsA PF14450.6 CCF54612.1 - 0.00041 20.7 5.4 0.086 13.3 0.1 3.8 3 1 0 3 3 3 2 Cell division protein FtsA FGGY_C PF02782.16 CCF54612.1 - 0.0019 18.0 0.0 0.0038 17.0 0.0 1.5 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain Tex_YqgF PF16921.5 CCF54612.1 - 0.042 14.3 0.5 0.12 12.8 0.5 1.8 1 0 0 1 1 1 0 Tex protein YqgF-like domain MAS20 PF02064.15 CCF54613.1 - 3.6e-37 127.3 0.4 3.6e-37 127.3 0.4 2.4 3 0 0 3 3 3 1 MAS20 protein import receptor RRN3 PF05327.11 CCF54613.1 - 0.17 10.4 2.1 0.21 10.1 2.1 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 SAPS PF04499.15 CCF54613.1 - 0.43 9.3 4.8 0.59 8.9 4.8 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Apt1 PF10351.9 CCF54613.1 - 3.1 6.5 12.8 4.4 6.1 12.8 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain Hid1 PF12722.7 CCF54613.1 - 8.7 4.3 6.6 12 3.9 6.6 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Bmt2 PF11968.8 CCF54614.1 - 1.8e-72 243.8 0.0 2.5e-72 243.3 0.0 1.2 1 0 0 1 1 1 1 25S rRNA (adenine(2142)-N(1))-methyltransferase, Bmt2 Methyltransf_23 PF13489.6 CCF54614.1 - 0.014 15.3 0.0 0.04 13.8 0.0 1.7 1 1 0 1 1 1 0 Methyltransferase domain ETF_QO PF05187.13 CCF54615.1 - 9.6e-43 144.6 0.1 1.7e-42 143.7 0.1 1.4 1 0 0 1 1 1 1 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S FAD_binding_2 PF00890.24 CCF54615.1 - 1.9e-07 30.5 0.5 1.3e-05 24.5 0.6 2.2 1 1 1 2 2 2 1 FAD binding domain NAD_binding_8 PF13450.6 CCF54615.1 - 2.8e-06 27.5 0.0 1.7e-05 24.9 0.0 2.4 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CCF54615.1 - 3.4e-06 26.9 0.9 0.00032 20.4 0.9 2.5 1 1 0 2 2 2 1 FAD dependent oxidoreductase HI0933_like PF03486.14 CCF54615.1 - 2.9e-05 23.0 0.6 4.6e-05 22.3 0.6 1.2 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox_2 PF07992.14 CCF54615.1 - 5e-05 22.7 0.0 7e-05 22.2 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 CCF54615.1 - 5.7e-05 22.5 0.0 0.00024 20.5 0.2 1.8 2 0 0 2 2 2 1 Thi4 family Pyr_redox_3 PF13738.6 CCF54615.1 - 0.00014 21.3 1.1 0.00021 20.6 1.1 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 CCF54615.1 - 0.00035 19.7 0.1 0.00057 19.0 0.1 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein FAD_binding_3 PF01494.19 CCF54615.1 - 0.0027 17.0 0.2 0.0044 16.3 0.2 1.3 1 0 0 1 1 1 1 FAD binding domain NAD_binding_9 PF13454.6 CCF54615.1 - 0.0042 17.1 0.1 0.0092 16.0 0.1 1.5 1 0 0 1 1 1 1 FAD-NAD(P)-binding FAD_oxidored PF12831.7 CCF54615.1 - 0.0052 16.2 0.3 0.0085 15.5 0.3 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase K_oxygenase PF13434.6 CCF54615.1 - 0.019 14.1 0.0 0.028 13.5 0.0 1.2 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) Trp_halogenase PF04820.14 CCF54615.1 - 0.025 13.4 0.7 0.065 12.1 0.7 1.7 1 0 0 1 1 1 0 Tryptophan halogenase GIDA PF01134.22 CCF54615.1 - 0.032 13.3 0.2 0.048 12.7 0.2 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A Fer4_7 PF12838.7 CCF54615.1 - 0.072 13.7 1.6 0.15 12.7 1.6 1.5 1 0 0 1 1 1 0 4Fe-4S dicluster domain Fer4_6 PF12837.7 CCF54615.1 - 2.2 8.5 5.1 0.24 11.6 0.5 1.8 2 0 0 2 2 2 0 4Fe-4S binding domain Barwin PF00967.17 CCF54616.1 - 3.7e-08 33.2 1.5 0.00076 19.3 0.2 2.6 2 1 0 2 2 2 2 Barwin family Spt20 PF12090.8 CCF54616.1 - 0.0044 16.7 2.7 0.0057 16.3 2.7 1.2 1 0 0 1 1 1 1 Spt20 family DPBB_1 PF03330.18 CCF54616.1 - 0.014 15.7 2.2 0.041 14.1 0.2 2.8 2 2 0 2 2 2 0 Lytic transglycolase GreA_GreB PF01272.19 CCF54616.1 - 0.017 15.0 0.2 1.8 8.5 0.0 2.4 2 0 0 2 2 2 0 Transcription elongation factor, GreA/GreB, C-term DUF4834 PF16118.5 CCF54616.1 - 0.23 12.5 1.1 0.46 11.5 1.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) SOG2 PF10428.9 CCF54616.1 - 0.44 9.7 7.2 0.51 9.5 7.2 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein FYVE PF01363.21 CCF54617.1 - 1e-21 76.8 3.6 1.9e-21 76.0 3.6 1.4 1 0 0 1 1 1 1 FYVE zinc finger Rbsn PF11464.8 CCF54617.1 - 1.8e-12 46.8 0.3 4.4e-12 45.5 0.3 1.7 1 0 0 1 1 1 1 Rabenosyn Rab binding domain DUF3348 PF11828.8 CCF54617.1 - 0.0068 16.1 0.7 0.0068 16.1 0.7 2.9 3 0 0 3 3 3 1 Protein of unknown function (DUF3348) DZR PF12773.7 CCF54617.1 - 2.4 8.2 5.1 3.8 7.6 2.3 2.2 2 0 0 2 2 2 0 Double zinc ribbon Methyltransf_7 PF03492.15 CCF54618.1 - 4.7e-10 39.2 0.0 0.0001 21.6 0.1 3.2 2 1 1 3 3 3 2 SAM dependent carboxyl methyltransferase DUF3670 PF12419.8 CCF54618.1 - 0.02 14.7 0.1 0.24 11.2 0.0 2.3 2 0 0 2 2 2 0 SNF2 Helicase protein WhiA_N PF10298.9 CCF54618.1 - 0.18 11.8 0.4 0.64 10.1 0.0 2.0 2 0 0 2 2 2 0 WhiA N-terminal LAGLIDADG-like domain GNAT_acetyltr_2 PF13718.6 CCF54619.1 - 1.1e-89 299.7 0.1 1.6e-88 296.0 0.0 2.5 2 0 0 2 2 2 1 GNAT acetyltransferase 2 Helicase_RecD PF05127.14 CCF54619.1 - 4.2e-62 209.1 0.0 7.6e-62 208.3 0.0 1.5 1 0 0 1 1 1 1 Helicase tRNA_bind_2 PF13725.6 CCF54619.1 - 4.1e-59 200.1 19.7 6.8e-57 192.9 1.9 3.3 1 1 1 2 2 2 2 Possible tRNA binding domain DUF1726 PF08351.11 CCF54619.1 - 2.1e-29 101.3 0.0 7.2e-29 99.6 0.0 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF1726) AAA_22 PF13401.6 CCF54619.1 - 0.0011 19.2 0.0 0.092 13.0 0.0 2.8 2 0 0 2 2 2 1 AAA domain Acetyltransf_1 PF00583.25 CCF54619.1 - 0.012 15.8 0.0 0.038 14.2 0.0 1.8 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 CCF54619.1 - 0.041 14.3 0.0 0.13 12.7 0.0 1.8 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain DEAD PF00270.29 CCF54619.1 - 0.12 12.2 0.0 0.22 11.3 0.0 1.4 1 0 0 1 1 1 0 DEAD/DEAH box helicase DNA_pol_phi PF04931.13 CCF54619.1 - 2.1 6.4 27.5 5 5.1 27.5 1.5 1 0 0 1 1 1 0 DNA polymerase phi Nop14 PF04147.12 CCF54619.1 - 2.7 6.1 27.4 3.8 5.6 27.4 1.2 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.14 CCF54619.1 - 4.4 5.5 17.6 7.1 4.8 17.6 1.3 1 0 0 1 1 1 0 CDC45-like protein NOA36 PF06524.12 CCF54619.1 - 5.9 6.1 23.8 11 5.2 23.8 1.3 1 0 0 1 1 1 0 NOA36 protein Sigma70_ner PF04546.13 CCF54619.1 - 6.2 6.7 17.6 14 5.5 15.0 2.7 2 0 0 2 2 2 0 Sigma-70, non-essential region DUF2457 PF10446.9 CCF54619.1 - 7.9 5.5 26.6 12 5.0 26.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Cwf_Cwc_15 PF04889.12 CCF54619.1 - 8.2 6.1 25.6 0.093 12.4 17.1 1.9 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein zf-PARP PF00645.18 CCF54620.1 - 4.8e-25 88.2 0.0 6.9e-25 87.7 0.0 1.2 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region AT_hook PF02178.19 CCF54620.1 - 3.7e-12 44.6 82.3 0.072 13.0 2.7 10.3 10 0 0 10 10 10 9 AT hook motif RNB PF00773.19 CCF54621.1 - 9.3e-106 353.8 0.0 9.3e-106 353.8 0.0 1.6 2 0 0 2 2 2 1 RNB domain Dis3l2_C_term PF17877.1 CCF54621.1 - 8.8e-24 83.6 0.1 8.8e-24 83.6 0.1 2.1 2 0 0 2 2 2 1 DIS3-like exonuclease 2 C terminal OB_Dis3 PF17849.1 CCF54621.1 - 4.3e-21 74.7 0.0 9.2e-21 73.7 0.0 1.6 1 0 0 1 1 1 1 Dis3-like cold-shock domain 2 (CSD2) Rrp44_S1 PF17215.3 CCF54621.1 - 0.003 17.5 0.3 0.011 15.7 0.0 2.1 2 0 0 2 2 2 1 S1 domain Rrp44_CSD1 PF17216.3 CCF54621.1 - 0.012 15.3 0.0 0.031 14.0 0.0 1.6 1 0 0 1 1 1 0 Rrp44-like cold shock domain Tubulin PF00091.25 CCF54622.1 - 6.4e-67 225.6 0.0 8.5e-67 225.2 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 CCF54622.1 - 7.5e-47 158.6 0.0 1.1e-46 158.0 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 CCF54622.1 - 0.00037 20.2 0.0 0.00099 18.8 0.0 1.7 1 0 0 1 1 1 1 Tubulin domain PTP_tm PF18861.1 CCF54622.1 - 0.075 13.0 0.0 0.14 12.1 0.0 1.3 1 0 0 1 1 1 0 Transmembrane domain of protein tyrosine phosphatase, receptor type J Tubulin_2 PF13809.6 CCF54622.1 - 0.18 11.0 0.0 0.27 10.4 0.0 1.2 1 0 0 1 1 1 0 Tubulin like Mito_carr PF00153.27 CCF54623.1 - 6.6e-59 195.9 6.5 1.1e-21 76.5 0.1 3.4 3 0 0 3 3 3 3 Mitochondrial carrier protein EF-hand_1 PF00036.32 CCF54623.1 - 0.00023 20.5 1.2 0.0027 17.2 0.2 3.2 4 0 0 4 4 4 1 EF hand EF-hand_6 PF13405.6 CCF54623.1 - 0.0015 18.3 0.1 0.0093 15.8 0.1 2.4 2 0 0 2 2 2 1 EF-hand domain EF-hand_7 PF13499.6 CCF54623.1 - 0.049 14.1 0.6 0.13 12.8 0.1 1.9 1 1 1 2 2 2 0 EF-hand domain pair ADH_zinc_N PF00107.26 CCF54626.1 - 2.5e-22 79.2 0.1 4.4e-22 78.5 0.1 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CCF54626.1 - 9e-10 38.4 0.1 2e-09 37.3 0.0 1.7 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 CCF54626.1 - 2.1e-06 28.8 0.1 8.6e-06 26.8 0.1 2.1 1 1 0 1 1 1 1 Zinc-binding dehydrogenase NAD_binding_7 PF13241.6 CCF54626.1 - 0.093 13.2 0.0 0.21 12.1 0.0 1.5 1 0 0 1 1 1 0 Putative NAD(P)-binding ELFV_dehydrog PF00208.21 CCF54626.1 - 0.095 12.4 0.2 0.21 11.3 0.0 1.6 2 0 0 2 2 2 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase XRN_M PF17846.1 CCF54627.1 - 6.4e-104 348.4 2.7 3.4e-103 346.0 2.7 1.9 1 1 0 1 1 1 1 Xrn1 helical domain XRN_N PF03159.18 CCF54627.1 - 2.1e-97 325.3 0.1 4.2e-97 324.3 0.0 1.5 2 0 0 2 2 2 1 XRN 5'-3' exonuclease N-terminus XRN1_D1 PF18332.1 CCF54627.1 - 6.4e-69 231.6 0.0 1.4e-68 230.4 0.0 1.7 1 0 0 1 1 1 1 Exoribonuclease Xrn1 D1 domain XRN1_D2_D3 PF18334.1 CCF54627.1 - 4.5e-22 78.1 0.0 1.1e-21 76.8 0.0 1.7 1 0 0 1 1 1 1 Exoribonuclease Xrn1 D2/D3 domain SH3_12 PF18129.1 CCF54627.1 - 2.5e-21 75.5 2.2 5e-21 74.6 0.7 2.1 2 0 0 2 2 2 1 Xrn1 SH3-like domain Lon_C PF05362.13 CCF54628.1 - 3e-66 222.9 0.3 5.9e-66 221.9 0.3 1.5 1 0 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain LON_substr_bdg PF02190.16 CCF54628.1 - 5e-32 111.5 0.1 1.2e-31 110.3 0.0 1.7 2 0 0 2 2 1 1 ATP-dependent protease La (LON) substrate-binding domain AAA PF00004.29 CCF54628.1 - 4.2e-21 75.7 0.0 1.1e-20 74.4 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 CCF54628.1 - 1.7e-06 28.1 0.0 3.5e-06 27.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) ChlI PF13541.6 CCF54628.1 - 2.8e-06 27.2 0.1 6.4e-06 26.0 0.1 1.7 1 0 0 1 1 1 1 Subunit ChlI of Mg-chelatase AAA_2 PF07724.14 CCF54628.1 - 4.8e-05 23.5 0.0 0.00012 22.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_PrkA PF08298.11 CCF54628.1 - 8.7e-05 21.6 0.0 0.00014 20.9 0.0 1.2 1 0 0 1 1 1 1 PrkA AAA domain AAA_16 PF13191.6 CCF54628.1 - 0.0014 19.0 0.9 0.0054 17.1 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 CCF54628.1 - 0.0023 18.2 0.1 0.064 13.5 0.1 2.5 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 CCF54628.1 - 0.0025 18.4 0.8 0.0078 16.8 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 CCF54628.1 - 0.0076 16.0 0.1 0.049 13.3 0.0 2.2 2 0 0 2 2 2 1 AAA domain RuvB_N PF05496.12 CCF54628.1 - 0.0078 16.0 0.0 0.026 14.3 0.0 1.9 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_14 PF13173.6 CCF54628.1 - 0.018 15.1 0.0 0.045 13.8 0.0 1.7 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 CCF54628.1 - 0.052 13.9 0.0 0.12 12.7 0.0 1.7 1 0 0 1 1 1 0 RNA helicase RsgA_GTPase PF03193.16 CCF54628.1 - 0.065 13.1 0.0 0.18 11.7 0.0 1.7 1 0 0 1 1 1 0 RsgA GTPase IstB_IS21 PF01695.17 CCF54628.1 - 0.071 12.8 0.0 0.14 11.9 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein NB-ARC PF00931.22 CCF54628.1 - 0.087 12.0 0.1 0.18 11.0 0.1 1.4 1 0 0 1 1 1 0 NB-ARC domain AAA_24 PF13479.6 CCF54628.1 - 0.097 12.4 0.0 0.19 11.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 CCF54628.1 - 0.1 13.1 1.1 0.38 11.3 0.1 2.3 2 0 0 2 2 2 0 ABC transporter TAF4 PF05236.14 CCF54628.1 - 0.12 12.1 0.1 0.12 12.1 0.1 3.0 4 0 0 4 4 4 0 Transcription initiation factor TFIID component TAF4 family NTPase_1 PF03266.15 CCF54628.1 - 0.16 11.8 0.5 1.6 8.7 0.0 2.6 2 1 1 3 3 3 0 NTPase SR-25 PF10500.9 CCF54630.1 - 0.023 14.3 15.9 0.028 14.1 15.9 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein MAGE_N PF12440.8 CCF54630.1 - 0.17 12.6 0.5 0.17 12.6 0.5 2.2 1 1 1 2 2 2 0 Melanoma associated antigen family N terminal Ribosomal_S16 PF00886.19 CCF54631.1 - 1.3e-26 92.5 0.0 2.8e-26 91.3 0.0 1.6 1 1 0 1 1 1 1 Ribosomal protein S16 Oxidored_FMN PF00724.20 CCF54631.1 - 0.15 11.3 0.0 0.2 10.9 0.0 1.1 1 0 0 1 1 1 0 NADH:flavin oxidoreductase / NADH oxidase family Bax1-I PF01027.20 CCF54632.1 - 2.9e-45 154.6 25.3 3.4e-45 154.4 25.3 1.0 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 BaxI_1 PF12811.7 CCF54632.1 - 0.0012 18.4 19.7 0.0033 17.0 20.0 1.5 1 1 0 1 1 1 1 Bax inhibitor 1 like CMAS PF02353.20 CCF54633.1 - 9.5e-62 208.8 0.3 1.2e-61 208.5 0.3 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_11 PF08241.12 CCF54633.1 - 3.6e-12 46.8 0.2 3e-10 40.6 0.0 2.9 4 0 0 4 4 3 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF54633.1 - 5.5e-12 46.2 0.0 3.8e-11 43.5 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCF54633.1 - 1.6e-10 41.1 0.0 2.9e-10 40.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF54633.1 - 1.7e-07 31.2 0.3 4.4e-07 29.8 0.0 1.8 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCF54633.1 - 1.6e-06 28.8 0.1 3.6e-06 27.6 0.1 1.6 1 0 0 1 1 1 1 Methyltransferase domain DOT1 PF08123.13 CCF54633.1 - 2.3e-05 24.0 0.0 0.00018 21.1 0.0 2.1 2 0 0 2 2 2 1 Histone methylation protein DOT1 MTS PF05175.14 CCF54633.1 - 0.00064 19.3 0.0 0.001 18.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain TehB PF03848.14 CCF54633.1 - 0.028 13.8 0.1 0.071 12.5 0.1 1.7 1 0 0 1 1 1 0 Tellurite resistance protein TehB PCMT PF01135.19 CCF54633.1 - 0.028 14.2 0.0 0.044 13.5 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) FtsJ PF01728.19 CCF54633.1 - 0.065 13.3 0.0 0.12 12.5 0.0 1.5 1 0 0 1 1 1 0 FtsJ-like methyltransferase RrnaAD PF00398.20 CCF54633.1 - 0.09 11.8 0.0 0.17 10.9 0.0 1.4 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase PrmA PF06325.13 CCF54633.1 - 0.13 11.7 0.0 0.21 10.9 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) 2-Hacid_dh_C PF02826.19 CCF54634.1 - 6.4e-58 195.0 0.0 9e-58 194.6 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 CCF54634.1 - 1.6e-19 69.9 0.0 2e-19 69.6 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 CCF54634.1 - 2.6e-06 27.7 0.0 5.5e-06 26.6 0.0 1.5 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 CCF54634.1 - 0.00096 19.7 0.0 0.0025 18.4 0.0 1.8 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent IlvN PF07991.12 CCF54634.1 - 0.001 18.7 0.0 0.017 14.7 0.0 2.2 2 0 0 2 2 2 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain Gln-synt_C-ter PF18318.1 CCF54634.1 - 0.011 15.5 0.0 0.021 14.7 0.0 1.3 1 0 0 1 1 1 0 Glutamine synthetase C-terminal domain INCENP_ARK-bind PF03941.15 CCF54635.1 - 0.031 14.2 3.7 0.063 13.2 3.7 1.5 1 0 0 1 1 1 0 Inner centromere protein, ARK binding region LPD34 PF18852.1 CCF54635.1 - 0.046 13.3 0.3 0.074 12.6 0.3 1.2 1 0 0 1 1 1 0 Large polyvalent protein associated domain 34 Peptidase_S10 PF00450.22 CCF54635.1 - 0.21 11.0 0.1 0.43 9.9 0.0 1.5 2 0 0 2 2 2 0 Serine carboxypeptidase DUF4611 PF15387.6 CCF54635.1 - 0.85 9.9 4.4 2.1 8.6 4.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) SRAP PF02586.14 CCF54636.1 - 1.4e-63 214.4 0.0 2.8e-63 213.4 0.0 1.5 1 0 0 1 1 1 1 SOS response associated peptidase (SRAP) TPR_MLP1_2 PF07926.12 CCF54637.1 - 4.8e-20 71.9 20.2 4.8e-20 71.9 20.2 18.8 8 6 9 17 17 17 5 TPR/MLP1/MLP2-like protein Fib_alpha PF08702.10 CCF54637.1 - 0.0015 18.7 7.4 0.0015 18.7 7.4 14.9 7 5 7 17 17 17 2 Fibrinogen alpha/beta chain family ABC_tran_CTD PF16326.5 CCF54637.1 - 0.0035 17.6 5.9 0.0035 17.6 5.9 23.6 16 6 7 25 25 25 1 ABC transporter C-terminal domain PKcGMP_CC PF16808.5 CCF54637.1 - 0.23 11.3 0.0 0.23 11.3 0.0 9.5 11 0 0 11 11 11 0 Coiled-coil N-terminus of cGMP-dependent protein kinase MqsA_antitoxin PF15731.5 CCF54637.1 - 2.3 8.3 5.2 9.9 6.3 0.2 4.6 3 0 0 3 3 3 0 Antitoxin component of bacterial toxin-antitoxin system, MqsA DUF1815 PF08844.10 CCF54637.1 - 3.7 7.6 9.6 0.17 11.9 0.4 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF1815) GRASP55_65 PF04495.14 CCF54638.1 - 2.5e-63 212.5 0.0 6e-55 185.3 0.0 2.1 2 0 0 2 2 2 2 GRASP55/65 PDZ-like domain PDZ_6 PF17820.1 CCF54638.1 - 0.00014 21.7 0.1 0.43 10.5 0.0 2.6 2 0 0 2 2 2 2 PDZ domain PDZ_2 PF13180.6 CCF54638.1 - 0.00041 20.6 0.0 0.22 11.9 0.0 2.6 3 0 0 3 3 3 2 PDZ domain Spc42p PF11544.8 CCF54639.1 - 0.016 15.2 0.9 0.047 13.7 0.9 1.8 1 0 0 1 1 1 0 Spindle pole body component Spc42p TMF_TATA_bd PF12325.8 CCF54639.1 - 0.027 14.7 1.2 0.078 13.2 1.2 1.7 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding Mt_ATP-synt_B PF05405.14 CCF54639.1 - 0.11 12.2 0.5 0.52 9.9 0.0 2.2 2 0 0 2 2 2 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) KIF1B PF12423.8 CCF54639.1 - 0.14 12.6 0.7 0.42 11.1 0.7 1.8 1 0 0 1 1 1 0 Kinesin protein 1B DUF2267 PF10025.9 CCF54639.1 - 0.2 12.0 3.4 5.1 7.4 0.2 3.1 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2267) CCDC144C PF14915.6 CCF54640.1 - 0.087 11.9 0.6 0.11 11.6 0.6 1.1 1 0 0 1 1 1 0 CCDC144C protein coiled-coil region SCP2 PF02036.17 CCF54641.1 - 1.2e-10 41.8 0.0 3.3e-10 40.3 0.0 1.8 1 1 1 2 2 2 1 SCP-2 sterol transfer family Alkyl_sulf_C PF14864.6 CCF54641.1 - 0.0042 17.3 0.0 0.0094 16.2 0.0 1.5 2 0 0 2 2 2 1 Alkyl sulfatase C-terminal RdRP PF05183.12 CCF54642.1 - 2.9e-149 498.4 0.0 4.2e-149 497.9 0.0 1.2 1 0 0 1 1 1 1 RNA dependent RNA polymerase DUF4640 PF15480.6 CCF54642.1 - 0.078 12.7 0.3 0.15 11.8 0.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4640) Pkinase PF00069.25 CCF54643.1 - 1.2e-34 119.9 0.0 7.3e-34 117.3 0.0 2.2 3 0 0 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF54643.1 - 6.1e-11 42.1 0.0 3.4e-10 39.6 0.0 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 CCF54643.1 - 0.00039 20.4 0.3 0.0014 18.6 0.3 2.0 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kinase-like PF14531.6 CCF54643.1 - 0.047 13.0 0.0 0.084 12.2 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Aminotran_3 PF00202.21 CCF54644.1 - 1.2e-100 337.0 0.0 1.5e-100 336.8 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.21 CCF54644.1 - 0.0069 15.6 0.0 0.012 14.9 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II ThiF PF00899.21 CCF54645.1 - 3.3e-17 62.7 0.0 8e-17 61.4 0.0 1.6 1 1 0 1 1 1 1 ThiF family zf-RRN7 PF11781.8 CCF54648.1 - 1.2e-06 28.1 0.1 2.1e-06 27.3 0.1 1.4 1 0 0 1 1 1 1 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 Auto_anti-p27 PF06677.12 CCF54648.1 - 0.48 10.6 1.2 0.86 9.8 1.2 1.4 1 0 0 1 1 1 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) DHHC PF01529.20 CCF54649.1 - 4.2e-36 124.0 5.1 4.2e-36 124.0 5.1 1.7 2 0 0 2 2 2 1 DHHC palmitoyltransferase Phage_holin_3_6 PF07332.11 CCF54649.1 - 0.045 13.8 1.9 0.061 13.4 0.1 1.9 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III RVT_2 PF07727.14 CCF54650.1 - 8.3e-53 179.5 0.0 1.1e-52 179.1 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Headcase PF16002.5 CCF54650.1 - 0.12 11.8 0.3 0.19 11.2 0.3 1.2 1 0 0 1 1 1 0 Headcase protein AAA_23 PF13476.6 CCF54651.1 - 9.2e-26 91.6 28.6 9.2e-26 91.6 28.6 8.0 1 1 3 4 4 4 1 AAA domain AAA_21 PF13304.6 CCF54651.1 - 4e-09 36.7 1.3 1e-05 25.5 0.8 4.5 3 2 1 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 CCF54651.1 - 3.3e-07 30.4 70.2 0.00055 19.8 13.1 5.0 1 1 1 2 2 2 1 AAA ATPase domain SMC_N PF02463.19 CCF54651.1 - 3.8e-07 29.8 0.0 3.8e-07 29.8 0.0 3.1 2 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain SbcCD_C PF13558.6 CCF54651.1 - 3.6e-06 27.1 0.0 1.3e-05 25.4 0.0 2.0 1 0 0 1 1 1 1 Putative exonuclease SbcCD, C subunit AAA_13 PF13166.6 CCF54651.1 - 0.0087 14.8 0.0 0.0087 14.8 0.0 6.9 2 1 4 6 6 6 3 AAA domain AAA_29 PF13555.6 CCF54651.1 - 0.02 14.6 0.0 0.043 13.6 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain FAM167 PF11652.8 CCF54651.1 - 0.45 11.0 6.4 0.66 10.5 0.9 4.3 2 1 1 3 3 3 0 FAM167 Cullin PF00888.22 CCF54653.1 - 1.5e-183 611.8 3.2 1.9e-183 611.5 3.2 1.1 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 CCF54653.1 - 3.2e-27 94.3 5.0 6.4e-27 93.4 1.6 2.6 2 0 0 2 2 2 1 Cullin protein neddylation domain Lipase_GDSL_2 PF13472.6 CCF54653.1 - 0.051 14.0 0.0 0.16 12.4 0.0 1.9 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family Penicillinase_R PF03965.16 CCF54653.1 - 0.057 13.8 9.7 3.2 8.1 0.2 5.3 4 2 1 5 5 5 0 Penicillinase repressor Phage_TAC_12 PF12363.8 CCF54653.1 - 0.13 12.7 0.9 0.46 10.9 0.1 2.4 2 0 0 2 2 2 0 Phage tail assembly chaperone protein, TAC AnfG_VnfG PF03139.15 CCF54653.1 - 0.19 11.8 2.7 0.17 12.0 0.3 2.2 3 0 0 3 3 3 0 Vanadium/alternative nitrogenase delta subunit DUF4404 PF14357.6 CCF54653.1 - 0.82 10.4 3.8 3.8 8.2 0.4 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4404) Ubie_methyltran PF01209.18 CCF54654.1 - 8.7e-73 244.5 0.2 6.7e-38 130.3 0.0 2.7 3 0 0 3 3 3 2 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.6 CCF54654.1 - 1.5e-13 51.2 0.0 2.3e-07 31.4 0.0 2.4 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_12 PF08242.12 CCF54654.1 - 2.1e-11 44.4 0.0 3.5e-11 43.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF54654.1 - 1.5e-10 41.6 0.0 5.2e-06 27.0 0.0 2.5 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_31 PF13847.6 CCF54654.1 - 1.7e-09 37.7 0.0 6.9e-09 35.7 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCF54654.1 - 1.1e-07 31.9 0.0 1.7e-07 31.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_28 PF02636.17 CCF54654.1 - 0.023 14.3 0.0 0.037 13.7 0.0 1.2 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_8 PF05148.15 CCF54654.1 - 0.026 14.4 0.0 0.1 12.4 0.0 1.9 3 0 0 3 3 3 0 Hypothetical methyltransferase Thiolase_N PF00108.23 CCF54659.1 - 4.3e-71 239.3 0.9 1.1e-70 237.9 0.1 1.9 2 1 0 2 2 2 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 CCF54659.1 - 2.9e-45 152.9 0.5 4.9e-45 152.2 0.5 1.3 1 0 0 1 1 1 1 Thiolase, C-terminal domain ACP_syn_III_C PF08541.10 CCF54659.1 - 5.9e-05 23.2 0.0 0.00018 21.6 0.0 1.9 1 0 0 1 1 1 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal ketoacyl-synt PF00109.26 CCF54659.1 - 0.00051 19.7 0.9 0.0015 18.2 0.1 2.3 4 0 0 4 4 4 1 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III PF08545.10 CCF54659.1 - 0.015 15.2 1.7 0.23 11.4 0.1 3.1 3 0 0 3 3 3 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III DUF2093 PF09866.9 CCF54659.1 - 0.14 11.6 0.0 0.36 10.3 0.0 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2093) MazG-like PF12643.7 CCF54659.1 - 0.18 12.1 0.0 1.9 8.8 0.0 2.4 2 0 0 2 2 2 0 MazG-like family Sas10 PF09368.10 CCF54660.1 - 1.1e-27 96.3 4.4 1.1e-27 96.3 4.4 2.7 3 0 0 3 3 3 1 Sas10 C-terminal domain Sas10_Utp3 PF04000.15 CCF54660.1 - 1.7e-06 28.6 0.0 1.7e-06 28.6 0.0 2.4 2 1 0 2 2 2 1 Sas10/Utp3/C1D family AbiEi_3_N PF17194.4 CCF54660.1 - 0.12 12.4 0.0 0.29 11.2 0.0 1.6 1 0 0 1 1 1 0 Transcriptional regulator, AbiEi antitoxin N-terminal domain Fcf2 PF08698.11 CCF54661.1 - 8.6e-22 77.4 3.3 1.1e-20 73.8 0.2 3.0 3 0 0 3 3 3 1 Fcf2 pre-rRNA processing RRN3 PF05327.11 CCF54661.1 - 0.41 9.1 8.4 1.3 7.5 7.4 2.0 2 0 0 2 2 2 0 RNA polymerase I specific transcription initiation factor RRN3 EPL1 PF10513.9 CCF54662.1 - 2.7e-25 89.6 0.0 2.7e-25 89.6 0.0 7.3 4 2 1 5 5 5 1 Enhancer of polycomb-like CK_II_beta PF01214.18 CCF54663.1 - 3.1e-75 252.0 0.0 3.9e-75 251.7 0.0 1.1 1 0 0 1 1 1 1 Casein kinase II regulatory subunit Pho88 PF10032.9 CCF54664.1 - 1e-74 249.8 0.0 1.1e-74 249.6 0.0 1.0 1 0 0 1 1 1 1 Phosphate transport (Pho88) Tom22 PF04281.13 CCF54665.1 - 9.8e-45 151.7 3.9 1.1e-44 151.5 3.9 1.0 1 0 0 1 1 1 1 Mitochondrial import receptor subunit Tom22 FAM176 PF14851.6 CCF54665.1 - 0.21 11.2 2.9 0.4 10.3 2.9 1.4 1 0 0 1 1 1 0 FAM176 family Pes-10 PF07149.11 CCF54665.1 - 0.74 8.8 6.5 1.2 8.2 6.5 1.3 1 0 0 1 1 1 0 Pes-10 VWA PF00092.28 CCF54667.1 - 7.4e-12 45.9 0.0 2.4e-11 44.2 0.0 1.8 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA_2 PF13519.6 CCF54667.1 - 1.2e-07 32.3 0.0 2.4e-07 31.4 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain Troponin PF00992.20 CCF54667.1 - 0.056 13.7 0.1 0.1 12.9 0.1 1.3 1 0 0 1 1 1 0 Troponin Integrin_beta PF00362.18 CCF54667.1 - 0.17 11.5 0.0 1.6 8.3 0.0 2.0 1 1 0 1 1 1 0 Integrin beta chain VWA domain HA2 PF04408.23 CCF54668.1 - 1e-25 90.1 0.0 2.1e-25 89.1 0.0 1.5 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 CCF54668.1 - 4.8e-18 65.3 0.1 1.7e-17 63.5 0.0 2.0 2 0 0 2 2 2 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 CCF54668.1 - 2.2e-10 40.9 0.0 5.3e-10 39.6 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 CCF54668.1 - 2.7e-07 30.9 0.0 6.4e-07 29.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain DEAD PF00270.29 CCF54668.1 - 3.3e-07 30.2 0.1 7.5e-07 29.1 0.1 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_19 PF13245.6 CCF54668.1 - 0.0004 20.7 0.1 0.00094 19.5 0.1 1.6 1 0 0 1 1 1 1 AAA domain ResIII PF04851.15 CCF54668.1 - 0.022 14.8 0.0 0.13 12.2 0.0 2.1 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit SRP54 PF00448.22 CCF54668.1 - 0.048 13.3 0.2 0.13 11.8 0.2 1.8 1 1 0 1 1 1 0 SRP54-type protein, GTPase domain Flavi_DEAD PF07652.14 CCF54668.1 - 0.08 12.9 0.4 0.23 11.4 0.4 1.8 1 1 0 1 1 1 0 Flavivirus DEAD domain DUF2075 PF09848.9 CCF54668.1 - 0.094 11.9 0.0 0.14 11.4 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_30 PF13604.6 CCF54668.1 - 0.097 12.4 0.0 0.18 11.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 CCF54668.1 - 0.1 12.0 0.1 0.59 9.6 0.0 2.3 3 0 0 3 3 3 0 PhoH-like protein Roc PF08477.13 CCF54668.1 - 0.14 12.3 0.0 0.29 11.4 0.0 1.5 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase 3HCDH_N PF02737.18 CCF54669.1 - 6.4e-52 176.0 1.2 1.4e-51 174.9 1.2 1.6 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.22 CCF54669.1 - 5.7e-32 110.2 0.1 1.6e-31 108.8 0.1 1.8 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain NAD_Gly3P_dh_N PF01210.23 CCF54669.1 - 0.0012 18.9 0.8 0.0028 17.7 0.8 1.6 1 1 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus UDPG_MGDP_dh_N PF03721.14 CCF54669.1 - 0.0019 17.8 0.6 0.004 16.7 0.6 1.6 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Sacchrp_dh_NADP PF03435.18 CCF54669.1 - 0.013 15.7 2.9 0.028 14.7 1.7 2.2 2 1 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain DUF1188 PF06690.11 CCF54669.1 - 0.024 14.2 0.1 0.045 13.3 0.1 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1188) NAD_binding_2 PF03446.15 CCF54669.1 - 0.028 14.6 3.2 0.2 11.8 2.1 2.6 2 1 0 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase Shikimate_DH PF01488.20 CCF54669.1 - 0.081 13.0 1.1 0.22 11.6 0.5 2.1 2 1 1 3 3 3 0 Shikimate / quinate 5-dehydrogenase F420_oxidored PF03807.17 CCF54669.1 - 0.11 13.0 4.6 5.1 7.7 4.6 2.6 1 1 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Seryl_tRNA_N PF02403.22 CCF54669.1 - 0.4 10.9 2.2 12 6.1 0.1 2.5 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Ribosomal_60s PF00428.19 CCF54670.1 - 1.4 9.6 8.7 2.1 9.0 8.6 1.4 1 1 0 1 1 1 0 60s Acidic ribosomal protein Prefoldin PF02996.17 CCF54671.1 - 1e-26 93.2 3.9 1.5e-26 92.7 3.9 1.3 1 0 0 1 1 1 1 Prefoldin subunit AIP3 PF03915.13 CCF54671.1 - 0.004 16.3 5.8 0.0051 16.0 5.8 1.0 1 0 0 1 1 1 1 Actin interacting protein 3 Baculo_PEP_C PF04513.12 CCF54671.1 - 0.0059 16.6 2.6 0.53 10.3 0.3 2.1 2 0 0 2 2 2 2 Baculovirus polyhedron envelope protein, PEP, C terminus UPF0449 PF15136.6 CCF54671.1 - 0.02 15.4 4.0 1.2 9.7 0.2 2.2 2 0 0 2 2 2 0 Uncharacterised protein family UPF0449 DUF1664 PF07889.12 CCF54671.1 - 0.023 14.7 6.8 0.81 9.7 1.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) CAF1 PF04857.20 CCF54671.1 - 0.027 13.6 0.5 0.032 13.4 0.5 1.1 1 0 0 1 1 1 0 CAF1 family ribonuclease SlyX PF04102.12 CCF54671.1 - 0.031 14.9 6.1 0.031 14.9 6.1 2.4 2 1 0 2 2 2 0 SlyX Prefoldin_2 PF01920.20 CCF54671.1 - 0.033 14.2 14.0 0.37 10.8 7.7 2.9 2 1 0 2 2 2 0 Prefoldin subunit Fib_alpha PF08702.10 CCF54671.1 - 0.041 14.1 4.1 0.81 9.9 0.6 2.1 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family XkdW PF09636.10 CCF54671.1 - 0.084 13.0 3.9 0.21 11.7 0.4 2.1 2 0 0 2 2 2 0 XkdW protein Cob_adeno_trans PF01923.18 CCF54671.1 - 0.1 12.7 2.6 0.22 11.7 2.6 1.7 1 1 0 1 1 1 0 Cobalamin adenosyltransferase ABC2_membrane_3 PF12698.7 CCF54671.1 - 0.11 11.6 1.0 0.12 11.5 1.0 1.0 1 0 0 1 1 1 0 ABC-2 family transporter protein CENP-Q PF13094.6 CCF54671.1 - 0.14 12.3 9.2 2.1 8.5 4.4 2.1 2 0 0 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit PHM7_cyt PF14703.6 CCF54671.1 - 0.15 12.2 5.9 0.46 10.7 5.8 1.7 1 1 0 1 1 1 0 Cytosolic domain of 10TM putative phosphate transporter DUF2508 PF10704.9 CCF54671.1 - 0.18 12.0 8.6 0.1 12.8 2.6 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF2508) Dzip-like_N PF13815.6 CCF54671.1 - 0.5 10.4 6.9 0.4 10.6 1.0 2.1 2 0 0 2 2 2 0 Iguana/Dzip1-like DAZ-interacting protein N-terminal FlaC_arch PF05377.11 CCF54671.1 - 3 8.3 8.2 19 5.7 0.0 3.1 3 1 0 3 3 3 0 Flagella accessory protein C (FlaC) GIT_CC PF16559.5 CCF54671.1 - 3 7.8 13.2 0.081 12.8 2.3 2.6 2 1 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor FlxA PF14282.6 CCF54671.1 - 3.6 7.6 16.5 0.55 10.2 8.1 2.2 2 0 0 2 2 2 0 FlxA-like protein DUF1192 PF06698.11 CCF54671.1 - 5.4 7.1 6.7 8.6 6.5 0.0 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF1192) GrpE PF01025.19 CCF54671.1 - 6.4 6.4 11.2 2.3 7.9 6.1 2.0 2 0 0 2 2 2 0 GrpE LPP PF04728.13 CCF54671.1 - 8.5 6.9 10.7 4.1 7.9 0.1 3.2 2 2 1 3 3 3 0 Lipoprotein leucine-zipper ATP-synt_DE_N PF02823.16 CCF54673.1 - 2.2e-15 56.3 0.1 3.4e-15 55.7 0.1 1.3 1 0 0 1 1 1 1 ATP synthase, Delta/Epsilon chain, beta-sandwich domain TFA2_Winged_2 PF18121.1 CCF54674.1 - 4e-18 64.8 0.1 1.2e-17 63.4 0.0 1.8 2 0 0 2 2 2 1 TFA2 Winged helix domain 2 TFIIE_beta PF02186.15 CCF54674.1 - 3.7e-08 33.5 0.0 8.3e-08 32.4 0.0 1.6 1 0 0 1 1 1 1 TFIIE beta subunit core domain ABC_membrane_2 PF06472.15 CCF54675.1 - 2.5e-94 315.7 1.6 3.3e-94 315.3 1.6 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.27 CCF54675.1 - 3.4e-19 69.7 0.0 7.2e-19 68.7 0.0 1.6 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CCF54675.1 - 3.8e-05 23.7 0.0 0.00011 22.2 0.0 1.8 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 CCF54675.1 - 0.0011 19.5 0.2 0.03 14.8 0.0 2.3 2 0 0 2 2 2 1 AAA domain SMC_N PF02463.19 CCF54675.1 - 0.023 14.2 0.0 0.18 11.2 0.0 2.1 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain Rad17 PF03215.15 CCF54675.1 - 0.062 13.2 0.0 0.14 12.1 0.0 1.5 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_29 PF13555.6 CCF54675.1 - 0.066 13.0 0.0 0.16 11.8 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain Adeno_IVa2 PF02456.15 CCF54675.1 - 0.1 11.4 0.0 0.17 10.6 0.0 1.3 1 0 0 1 1 1 0 Adenovirus IVa2 protein AAA_15 PF13175.6 CCF54675.1 - 0.2 11.3 0.2 0.41 10.3 0.0 1.5 2 0 0 2 2 2 0 AAA ATPase domain PPR_2 PF13041.6 CCF54676.1 - 5.8e-19 68.0 0.0 0.0012 18.9 0.0 7.0 5 2 2 7 7 7 5 PPR repeat family PPR_3 PF13812.6 CCF54676.1 - 2.2e-13 50.0 0.0 0.021 14.9 0.0 4.5 4 0 0 4 4 4 4 Pentatricopeptide repeat domain PPR_1 PF12854.7 CCF54676.1 - 4e-13 48.8 1.2 0.0098 15.6 0.0 6.5 6 1 0 6 6 6 4 PPR repeat PPR PF01535.20 CCF54676.1 - 4e-13 48.6 5.3 0.0026 17.9 0.0 7.2 8 1 0 8 8 8 3 PPR repeat PPR_long PF17177.4 CCF54676.1 - 7.1e-08 32.1 0.0 0.0039 16.6 0.0 3.5 3 1 0 3 3 3 2 Pentacotripeptide-repeat region of PRORP Sec3_C PF09763.9 CCF54677.1 - 1.8e-186 621.6 0.0 2.5e-186 621.2 0.0 1.2 1 0 0 1 1 1 1 Exocyst complex component Sec3 Sec3-PIP2_bind PF15277.6 CCF54677.1 - 1.8e-23 82.5 0.2 3.4e-23 81.6 0.2 1.5 1 0 0 1 1 1 1 Exocyst complex component SEC3 N-terminal PIP2 binding PH Vps52 PF04129.12 CCF54677.1 - 5.7e-06 25.4 0.1 1.1e-05 24.4 0.1 1.4 1 0 0 1 1 1 1 Vps52 / Sac2 family Spt5_N PF11942.8 CCF54677.1 - 0.25 12.3 2.1 1 10.4 2.1 2.1 1 0 0 1 1 1 0 Spt5 transcription elongation factor, acidic N-terminal Ipi1_N PF12333.8 CCF54678.1 - 0.059 14.0 0.1 0.12 12.9 0.1 1.5 1 0 0 1 1 1 0 Rix1 complex component involved in 60S ribosome maturation rve PF00665.26 CCF54679.1 - 6.5e-09 36.0 0.1 1.4e-08 34.9 0.1 1.6 1 0 0 1 1 1 1 Integrase core domain gag_pre-integrs PF13976.6 CCF54679.1 - 0.013 15.4 0.6 0.035 14.0 0.6 1.7 1 0 0 1 1 1 0 GAG-pre-integrase domain RVT_2 PF07727.14 CCF54679.1 - 0.14 11.8 0.0 0.25 10.9 0.0 1.5 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) Glyoxalase_2 PF12681.7 CCF54680.1 - 0.0058 16.6 0.4 1.8 8.5 0.0 2.3 1 1 1 2 2 2 2 Glyoxalase-like domain Ysc84 PF04366.12 CCF54681.1 - 3.7e-42 143.1 0.1 1.1e-41 141.6 0.1 1.8 1 0 0 1 1 1 1 Las17-binding protein actin regulator Glyco_transf_8 PF01501.20 CCF54682.1 - 5.2e-18 65.5 0.0 2e-16 60.4 0.0 2.5 2 1 0 2 2 2 1 Glycosyl transferase family 8 Nucleotid_trans PF03407.16 CCF54682.1 - 0.1 12.5 0.0 0.19 11.7 0.0 1.3 1 0 0 1 1 1 0 Nucleotide-diphospho-sugar transferase TFIIF_alpha PF05793.12 CCF54682.1 - 3.1 6.3 13.6 6.4 5.3 13.6 1.6 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) CDC45 PF02724.14 CCF54682.1 - 3.3 5.9 5.9 5.2 5.2 5.9 1.2 1 0 0 1 1 1 0 CDC45-like protein NOA36 PF06524.12 CCF54682.1 - 5.3 6.3 7.1 7.9 5.7 7.1 1.2 1 0 0 1 1 1 0 NOA36 protein PI3_PI4_kinase PF00454.27 CCF54683.1 - 1.1e-52 179.3 0.0 2.3e-52 178.3 0.0 1.6 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FAT PF02259.23 CCF54683.1 - 3.1e-23 82.6 0.1 9.2e-23 81.0 0.1 1.8 1 0 0 1 1 1 1 FAT domain UME PF08064.13 CCF54683.1 - 5.5e-23 80.8 0.1 8.7e-22 77.0 0.0 3.1 2 0 0 2 2 2 1 UME (NUC010) domain FATC PF02260.20 CCF54683.1 - 3.5e-11 42.7 0.0 1e-10 41.2 0.0 1.9 1 0 0 1 1 1 1 FATC domain DUF2937 PF11157.8 CCF54683.1 - 0.056 13.2 0.2 0.48 10.1 0.1 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2937) DUF3385 PF11865.8 CCF54683.1 - 0.086 12.7 0.0 0.98 9.3 0.0 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF3385) TPR_14 PF13428.6 CCF54683.1 - 0.36 11.8 1.9 5.9 8.0 0.0 4.3 3 0 0 3 3 3 0 Tetratricopeptide repeat MOZART1 PF12554.8 CCF54684.1 - 2.9e-21 75.0 0.5 3.4e-21 74.8 0.5 1.1 1 0 0 1 1 1 1 Mitotic-spindle organizing gamma-tubulin ring associated SRP54_N PF02881.19 CCF54684.1 - 0.0017 18.5 0.2 0.002 18.3 0.2 1.3 1 1 0 1 1 1 1 SRP54-type protein, helical bundle domain EcoEI_R_C PF08463.10 CCF54684.1 - 0.047 13.8 0.0 0.051 13.7 0.0 1.0 1 0 0 1 1 1 0 EcoEI R protein C-terminal MRC1 PF09444.10 CCF54685.1 - 2.7 8.5 7.6 0.35 11.4 1.1 2.2 2 0 0 2 2 2 0 MRC1-like domain PEP_mutase PF13714.6 CCF54686.1 - 6.2e-39 133.9 0.2 7.4e-39 133.6 0.2 1.1 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase ICL PF00463.21 CCF54686.1 - 2.5e-14 52.7 0.2 3.4e-14 52.3 0.2 1.1 1 0 0 1 1 1 1 Isocitrate lyase family UreF PF01730.16 CCF54687.1 - 3.8e-20 72.8 0.1 6.2e-20 72.1 0.1 1.2 1 0 0 1 1 1 1 UreF DUF4234 PF14018.6 CCF54688.1 - 0.044 13.9 2.0 0.16 12.1 2.3 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4234) CoA_transf_3 PF02515.17 CCF54690.1 - 1.2e-32 113.5 0.0 4.9e-32 111.5 0.0 1.9 2 0 0 2 2 2 1 CoA-transferase family III DEAD_assoc PF08494.11 CCF54691.1 - 0.0038 17.0 0.1 0.0056 16.5 0.1 1.3 1 0 0 1 1 1 1 DEAD/H associated zf-CCHC_4 PF14392.6 CCF54691.1 - 0.23 11.2 3.8 0.38 10.5 3.8 1.3 1 0 0 1 1 1 0 Zinc knuckle RVT_2 PF07727.14 CCF54692.1 - 4.1e-17 62.6 0.0 5.4e-17 62.2 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Oxysterol_BP PF01237.18 CCF54694.1 - 1.3e-119 399.4 0.0 2.5e-119 398.5 0.0 1.4 1 0 0 1 1 1 1 Oxysterol-binding protein PH_8 PF15409.6 CCF54694.1 - 8.7e-16 58.0 1.1 1.8e-15 57.0 0.0 2.1 2 0 0 2 2 2 1 Pleckstrin homology domain PH PF00169.29 CCF54694.1 - 2.4e-06 28.0 0.0 5.9e-06 26.7 0.0 1.7 1 0 0 1 1 1 1 PH domain FAM72 PF14976.6 CCF54696.1 - 8.5e-17 61.6 5.8 2.3e-16 60.3 5.8 1.7 1 1 0 1 1 1 1 FAM72 protein Yippee-Mis18 PF03226.14 CCF54696.1 - 0.085 13.1 8.2 0.73 10.1 0.1 2.5 2 1 0 2 2 2 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly IGPD PF00475.18 CCF54697.1 - 8.2e-61 204.5 0.7 1.4e-60 203.8 0.3 1.5 2 0 0 2 2 2 1 Imidazoleglycerol-phosphate dehydratase PIN PF01850.21 CCF54697.1 - 0.13 12.7 0.0 0.26 11.8 0.0 1.5 1 0 0 1 1 1 0 PIN domain PLDc_2 PF13091.6 CCF54698.1 - 2e-16 60.1 0.0 4.2e-07 29.9 0.0 2.3 2 0 0 2 2 2 2 PLD-like domain PLDc PF00614.22 CCF54698.1 - 4.7e-06 26.6 4.1 0.0077 16.4 0.2 3.3 3 0 0 3 3 3 2 Phospholipase D Active site motif MitMem_reg PF13012.6 CCF54699.1 - 8.1e-36 122.8 0.2 1.3e-35 122.2 0.2 1.3 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function JAB PF01398.21 CCF54699.1 - 1.3e-30 105.7 0.0 2.4e-30 104.9 0.0 1.4 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease AAA_11 PF13086.6 CCF54700.1 - 4.6e-68 229.8 0.0 4.6e-68 229.8 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_12 PF13087.6 CCF54700.1 - 7.9e-55 185.6 0.0 1.5e-54 184.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 CCF54700.1 - 2.3e-11 43.8 1.1 6.8e-07 29.2 0.0 2.7 3 0 0 3 3 3 2 AAA domain Viral_helicase1 PF01443.18 CCF54700.1 - 2.3e-08 34.1 0.1 0.071 12.8 0.0 3.4 3 0 0 3 3 3 3 Viral (Superfamily 1) RNA helicase AAA_19 PF13245.6 CCF54700.1 - 3.9e-08 33.8 0.0 2.6e-07 31.1 0.0 2.2 2 0 0 2 2 2 1 AAA domain UvrD-helicase PF00580.21 CCF54700.1 - 4.1e-05 23.3 0.2 8.6e-05 22.2 0.2 1.6 1 1 0 1 1 1 1 UvrD/REP helicase N-terminal domain UvrD_C_2 PF13538.6 CCF54700.1 - 0.00013 21.7 0.0 0.00034 20.4 0.0 1.7 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_25 PF13481.6 CCF54700.1 - 0.0005 19.7 0.0 0.0024 17.5 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 CCF54700.1 - 0.00059 20.3 0.3 0.0036 17.7 0.0 2.4 2 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 CCF54700.1 - 0.0013 19.0 0.0 0.006 16.9 0.0 2.3 2 1 0 2 2 2 1 AAA domain AAA PF00004.29 CCF54700.1 - 0.0082 16.6 0.0 0.028 14.8 0.0 2.0 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DEAD PF00270.29 CCF54700.1 - 0.021 14.6 0.0 0.11 12.2 0.0 2.2 1 1 0 1 1 1 0 DEAD/DEAH box helicase DUF2075 PF09848.9 CCF54700.1 - 0.026 13.8 3.3 0.059 12.6 0.0 3.0 3 1 0 3 3 3 0 Uncharacterized conserved protein (DUF2075) Helicase_RecD PF05127.14 CCF54700.1 - 0.043 13.7 0.0 2 8.3 0.0 2.6 1 1 1 2 2 2 0 Helicase Rrn6 PF10214.9 CCF54700.1 - 0.06 11.8 0.1 0.16 10.5 0.0 1.6 2 0 0 2 2 2 0 RNA polymerase I-specific transcription-initiation factor AAA_7 PF12775.7 CCF54700.1 - 0.11 12.0 0.0 0.27 10.7 0.0 1.6 2 0 0 2 2 2 0 P-loop containing dynein motor region DUF4798 PF16055.5 CCF54700.1 - 0.85 9.9 5.0 5.1 7.4 2.4 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4798) IKI3 PF04762.12 CCF54701.1 - 9.6e-289 960.5 0.0 1.3e-288 960.1 0.0 1.1 1 0 0 1 1 1 1 IKI3 family Lyase_1 PF00206.20 CCF54701.1 - 0.018 14.4 0.0 2.2 7.6 0.0 2.5 2 0 0 2 2 2 0 Lyase ANAPC4_WD40 PF12894.7 CCF54701.1 - 0.046 14.0 0.1 25 5.3 0.0 4.2 4 1 1 5 5 5 0 Anaphase-promoting complex subunit 4 WD40 domain TPR_12 PF13424.6 CCF54701.1 - 0.11 12.9 3.9 2 8.8 1.7 3.4 2 1 0 2 2 2 0 Tetratricopeptide repeat DUF1599 PF07659.11 CCF54701.1 - 0.17 12.4 0.1 29 5.2 0.0 2.8 2 0 0 2 2 2 0 Nucleotide modification associated domain 1 Se-cys_synth_N PF12390.8 CCF54701.1 - 0.19 12.0 0.5 0.98 9.7 0.0 2.5 2 0 0 2 2 2 0 Selenocysteine synthase N terminal Pkinase PF00069.25 CCF54702.1 - 3.4e-67 226.6 0.0 4.4e-67 226.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCF54702.1 - 5e-34 117.8 0.0 7e-34 117.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCF54702.1 - 0.0046 16.3 0.0 0.0083 15.5 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Ribosomal_L14 PF00238.19 CCF54703.1 - 1.3e-45 154.4 1.7 1.5e-45 154.2 1.7 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e MBOAT_2 PF13813.6 CCF54704.1 - 0.0012 19.1 2.5 0.0038 17.5 2.5 1.8 1 0 0 1 1 1 1 Membrane bound O-acyl transferase family PPR_2 PF13041.6 CCF54706.1 - 4.1e-48 161.4 2.9 3.9e-12 46.2 0.0 10.5 8 3 3 11 11 11 6 PPR repeat family PPR PF01535.20 CCF54706.1 - 6.8e-41 135.7 5.4 4.2e-06 26.6 0.0 12.9 12 0 0 12 12 12 8 PPR repeat PPR_3 PF13812.6 CCF54706.1 - 1.7e-37 127.3 0.0 3.7e-10 39.7 0.0 8.7 8 2 2 10 10 9 7 Pentatricopeptide repeat domain PPR_1 PF12854.7 CCF54706.1 - 1.8e-29 101.1 0.4 0.00059 19.5 0.0 9.8 10 0 0 10 10 10 6 PPR repeat PPR_long PF17177.4 CCF54706.1 - 2.5e-15 56.4 0.3 1.4e-09 37.6 0.0 4.7 4 1 1 5 5 5 2 Pentacotripeptide-repeat region of PRORP TPR_14 PF13428.6 CCF54706.1 - 1e-06 29.0 22.0 1.7 9.7 0.1 10.1 9 1 1 10 10 8 1 Tetratricopeptide repeat TPR_19 PF14559.6 CCF54706.1 - 2.1e-06 28.2 2.7 13 6.4 0.1 6.5 5 1 0 6 6 6 0 Tetratricopeptide repeat TPR_12 PF13424.6 CCF54706.1 - 0.0006 20.1 16.0 0.9 9.9 0.2 6.8 7 0 0 7 7 6 2 Tetratricopeptide repeat TPR_2 PF07719.17 CCF54706.1 - 0.00075 19.4 11.9 1.4 9.3 0.0 6.2 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_16 PF13432.6 CCF54706.1 - 0.0019 18.8 14.0 13 6.5 0.5 5.8 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_7 PF13176.6 CCF54706.1 - 0.0041 17.0 9.6 0.93 9.7 0.1 6.3 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_1 PF00515.28 CCF54706.1 - 0.019 14.8 11.1 1 9.3 0.5 5.6 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_8 PF13181.6 CCF54706.1 - 0.021 15.0 7.5 20 5.7 0.1 5.1 4 0 0 4 4 4 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 CCF54706.1 - 0.025 14.6 0.1 6 7.0 0.0 2.8 2 0 0 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat SPOB_a PF14689.6 CCF54706.1 - 0.044 13.5 0.1 0.53 10.0 0.0 2.8 3 0 0 3 3 3 0 Sensor_kinase_SpoOB-type, alpha-helical domain TetR_C_1 PF02909.17 CCF54706.1 - 0.13 12.0 0.1 1.2 8.9 0.0 2.6 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain TPR_4 PF07721.14 CCF54706.1 - 0.49 11.2 15.0 9.9 7.1 0.2 6.8 7 1 1 8 8 6 0 Tetratricopeptide repeat YEATS PF03366.16 CCF54707.1 - 5.3e-40 135.3 0.0 7.8e-40 134.7 0.0 1.2 1 0 0 1 1 1 1 YEATS family Tyrosinase PF00264.20 CCF54708.1 - 1.8e-18 67.7 1.4 2.6e-18 67.1 1.4 1.2 1 0 0 1 1 1 1 Common central domain of tyrosinase LURAP PF14854.6 CCF54708.1 - 0.083 12.8 0.9 16 5.4 0.0 2.4 1 1 1 2 2 2 0 Leucine rich adaptor protein RVT_2 PF07727.14 CCF54711.1 - 1.1e-25 90.7 0.3 3.6e-19 69.4 0.0 2.3 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 CCF54712.1 - 3.1e-07 30.6 0.1 5.9e-07 29.7 0.1 1.5 1 0 0 1 1 1 1 Integrase core domain zf-CCHC PF00098.23 CCF54712.1 - 4.7 7.5 13.1 0.086 13.0 4.9 2.6 3 0 0 3 3 3 0 Zinc knuckle FAD_binding_7 PF03441.14 CCF54714.1 - 8.9e-51 172.2 0.9 1.5e-50 171.5 0.9 1.3 1 0 0 1 1 1 1 FAD binding domain of DNA photolyase DNA_photolyase PF00875.18 CCF54714.1 - 8.4e-23 81.2 0.0 2.4e-22 79.7 0.0 1.7 1 1 0 1 1 1 1 DNA photolyase 7TMR-DISMED2 PF07696.11 CCF54714.1 - 0.023 14.7 0.5 2.2 8.4 0.1 2.4 1 1 1 2 2 2 0 7TMR-DISM extracellular 2 RNA_pol_Rpb2_6 PF00562.28 CCF54715.1 - 2.7e-114 382.2 0.1 5.9e-114 381.1 0.1 1.5 1 1 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 CCF54715.1 - 2.4e-30 105.6 0.0 3.8e-30 104.9 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_3 PF04565.16 CCF54715.1 - 1.6e-26 92.3 0.0 4.1e-26 90.9 0.0 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpa2_4 PF06883.12 CCF54715.1 - 5e-24 84.1 0.0 2e-23 82.2 0.0 2.1 2 0 0 2 2 2 1 RNA polymerase I, Rpa2 specific domain RNA_pol_Rpb2_2 PF04561.14 CCF54715.1 - 8.9e-19 67.9 0.0 1.5e-18 67.1 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_7 PF04560.20 CCF54715.1 - 3.4e-18 65.8 0.1 3.7e-15 56.1 0.1 2.6 2 0 0 2 2 2 2 RNA polymerase Rpb2, domain 7 Porphobil_deam PF01379.20 CCF54716.1 - 4.1e-66 222.4 0.0 5.6e-64 215.4 0.0 2.4 1 1 0 1 1 1 1 Porphobilinogen deaminase, dipyromethane cofactor binding domain Porphobil_deamC PF03900.15 CCF54716.1 - 5.8e-16 58.6 0.0 2.4e-09 37.4 0.0 2.7 2 0 0 2 2 2 2 Porphobilinogen deaminase, C-terminal domain YihI PF04220.12 CCF54716.1 - 0.07 12.8 5.4 1.4 8.6 0.5 2.5 2 0 0 2 2 2 0 Der GTPase activator (YihI) DUF848 PF05852.11 CCF54716.1 - 0.17 12.0 0.1 0.17 12.0 0.1 2.4 2 0 0 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) ANAPC4_WD40 PF12894.7 CCF54717.1 - 0.00013 22.2 0.0 0.88 9.9 0.0 5.1 4 2 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 CCF54717.1 - 0.0021 18.9 0.8 32 5.6 0.0 5.4 6 0 0 6 6 6 1 WD domain, G-beta repeat SPT6_acidic PF14632.6 CCF54717.1 - 0.24 12.0 6.2 0.59 10.7 6.2 1.6 1 0 0 1 1 1 0 Acidic N-terminal SPT6 DUF4196 PF13846.6 CCF54717.1 - 2.5 8.3 9.3 0.54 10.5 5.2 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4196) CitMHS PF03600.16 CCF54718.1 - 5.7e-10 38.9 4.1 5.7e-10 38.9 4.1 2.2 2 1 0 2 2 2 1 Citrate transporter ArsB PF02040.15 CCF54718.1 - 5.6e-06 25.9 12.9 5.2e-05 22.8 0.7 2.5 2 1 0 2 2 2 2 Arsenical pump membrane protein Pex14_N PF04695.13 CCF54718.1 - 0.00081 20.1 2.3 0.004 17.8 0.1 2.5 3 0 0 3 3 3 1 Peroxisomal membrane anchor protein (Pex14p) conserved region FtsJ PF01728.19 CCF54719.1 - 2e-34 119.3 0.1 2.6e-34 118.9 0.1 1.1 1 0 0 1 1 1 1 FtsJ-like methyltransferase CRAM_rpt PF07016.11 CCF54719.1 - 0.22 11.4 1.4 13 5.7 0.2 2.3 2 0 0 2 2 2 0 Cysteine-rich acidic integral membrane protein precursor Pyr_redox_2 PF07992.14 CCF54721.1 - 1.7e-70 237.6 0.7 2.7e-70 236.9 0.4 1.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 CCF54721.1 - 1e-28 99.7 1.2 2.4e-28 98.6 1.2 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 CCF54721.1 - 3.3e-22 78.8 3.3 1.6e-18 67.0 0.0 2.9 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CCF54721.1 - 1.6e-14 53.9 0.2 1.8e-12 47.2 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CCF54721.1 - 1.4e-06 27.3 2.8 0.011 14.5 0.0 3.1 3 0 0 3 3 3 2 HI0933-like protein FAD_oxidored PF12831.7 CCF54721.1 - 5.3e-05 22.8 0.1 0.00025 20.5 0.2 1.9 2 0 0 2 2 2 1 FAD dependent oxidoreductase K_oxygenase PF13434.6 CCF54721.1 - 0.0021 17.2 0.2 0.015 14.5 0.0 2.3 2 1 1 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 CCF54721.1 - 0.0077 16.4 1.2 0.025 14.8 1.2 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_7 PF13241.6 CCF54721.1 - 0.12 12.8 0.1 4.2 7.9 0.0 2.4 2 0 0 2 2 2 0 Putative NAD(P)-binding FAD_binding_2 PF00890.24 CCF54721.1 - 0.44 9.6 5.5 0.15 11.1 2.4 1.9 2 1 0 2 2 2 0 FAD binding domain DAO PF01266.24 CCF54721.1 - 2.8 7.4 6.5 12 5.4 0.2 3.1 4 0 0 4 4 4 0 FAD dependent oxidoreductase GIDA PF01134.22 CCF54721.1 - 8.3 5.4 7.4 16 4.4 1.0 3.3 4 1 0 4 4 4 0 Glucose inhibited division protein A FH2 PF02181.23 CCF54722.1 - 1.8e-86 290.6 5.0 1.4e-85 287.7 0.0 2.6 2 1 0 2 2 2 1 Formin Homology 2 Domain Drf_GBD PF06371.13 CCF54722.1 - 1.3e-27 96.6 2.4 1.2e-20 73.9 0.1 3.5 3 0 0 3 3 3 2 Diaphanous GTPase-binding Domain Drf_FH3 PF06367.16 CCF54722.1 - 1.4e-19 70.4 2.5 3.8e-19 69.1 0.9 2.3 2 0 0 2 2 2 1 Diaphanous FH3 Domain Erp_C PF06780.11 CCF54722.1 - 0.034 14.2 0.7 0.25 11.3 0.0 2.7 2 0 0 2 2 2 0 Erp protein C-terminus DUF630 PF04783.12 CCF54722.1 - 0.17 12.1 0.5 19 5.5 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF630) TMF_DNA_bd PF12329.8 CCF54722.1 - 0.95 9.5 34.8 2.1 8.4 14.0 5.6 3 2 0 3 3 3 0 TATA element modulatory factor 1 DNA binding DUF4407 PF14362.6 CCF54722.1 - 1.5 8.1 32.6 0.095 12.0 2.2 3.8 2 1 2 4 4 4 0 Domain of unknown function (DUF4407) ZapB PF06005.12 CCF54722.1 - 2.5 8.6 0.0 2.5 8.6 0.0 5.7 3 1 2 5 5 5 0 Cell division protein ZapB Fez1 PF06818.15 CCF54722.1 - 7.4 7.0 26.1 13 6.2 19.2 2.7 1 1 1 2 2 2 0 Fez1 MRP-S25 PF13741.6 CCF54723.1 - 5.3e-61 206.1 0.6 7.6e-61 205.6 0.1 1.4 2 0 0 2 2 2 1 Mitochondrial ribosomal protein S25 MRP-S23 PF10484.9 CCF54723.1 - 9.2e-06 25.9 0.6 0.15 12.3 0.0 2.7 2 0 0 2 2 2 2 Mitochondrial ribosomal protein S23 RNase_PH PF01138.21 CCF54724.1 - 3.3e-11 43.8 0.2 4.6e-10 40.1 0.0 2.1 2 0 0 2 2 2 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 CCF54724.1 - 5.8e-10 39.1 0.0 1.7e-08 34.4 0.0 2.5 1 1 0 1 1 1 1 3' exoribonuclease family, domain 2 Methyltransf_25 PF13649.6 CCF54725.1 - 2.1e-16 60.4 0.0 4.1e-16 59.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF54725.1 - 8.4e-15 55.2 0.0 1.6e-14 54.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCF54725.1 - 1.9e-13 50.6 0.0 3.3e-13 49.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF54725.1 - 6.1e-10 39.1 0.0 1.1e-09 38.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CCF54725.1 - 9.9e-09 34.9 0.0 1.6e-08 34.2 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 CCF54725.1 - 4.9e-08 33.6 0.0 9.3e-08 32.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CCF54725.1 - 0.00039 20.0 0.0 0.00078 19.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_4 PF02390.17 CCF54725.1 - 0.16 11.4 0.0 0.31 10.5 0.0 1.4 1 0 0 1 1 1 0 Putative methyltransferase Skp1_POZ PF03931.15 CCF54726.1 - 5.4e-07 29.7 0.0 0.0063 16.7 0.0 2.2 2 0 0 2 2 2 2 Skp1 family, tetramerisation domain Myb_DNA-binding PF00249.31 CCF54727.1 - 3.7e-07 30.2 0.1 0.00041 20.5 0.0 2.6 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 CCF54727.1 - 0.00073 19.7 0.1 0.028 14.7 0.0 2.6 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 CCF54727.1 - 0.00089 19.1 0.1 0.053 13.4 0.0 2.7 2 0 0 2 2 2 1 Myb DNA-binding like UQ_con PF00179.26 CCF54728.1 - 6.9e-54 181.3 0.0 7.7e-54 181.1 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 CCF54728.1 - 0.0025 18.1 0.0 0.0027 18.0 0.0 1.3 1 0 0 1 1 1 1 RWD domain Prok-E2_B PF14461.6 CCF54728.1 - 0.0052 16.5 0.0 0.0064 16.2 0.0 1.1 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.13 CCF54728.1 - 0.037 13.9 0.0 0.057 13.3 0.0 1.3 1 0 0 1 1 1 0 UEV domain Glycophorin_A PF01102.18 CCF54730.1 - 0.024 14.9 0.0 0.18 12.1 0.0 2.6 1 1 0 1 1 1 0 Glycophorin A MRP-L20 PF12824.7 CCF54730.1 - 0.042 14.0 2.5 0.12 12.5 0.0 2.6 2 0 0 2 2 2 0 Mitochondrial ribosomal protein subunit L20 Glyco_tran_28_C PF04101.16 CCF54732.1 - 8.2e-20 71.4 0.0 3.3e-14 53.2 0.0 2.1 2 0 0 2 2 2 2 Glycosyltransferase family 28 C-terminal domain MOSC PF03473.17 CCF54733.1 - 1.7e-19 70.1 0.0 4.6e-19 68.7 0.0 1.7 1 1 0 1 1 1 1 MOSC domain MOSC_N PF03476.16 CCF54733.1 - 1.3e-18 67.0 0.0 2.5e-18 66.1 0.0 1.5 1 0 0 1 1 1 1 MOSC N-terminal beta barrel domain Csm1 PF12539.8 CCF54734.1 - 1.8e-06 28.5 0.0 5.8e-06 26.8 0.0 1.9 1 1 0 1 1 1 1 Chromosome segregation protein Csm1/Pcs1 Filament PF00038.21 CCF54734.1 - 0.0063 16.1 20.3 0.01 15.5 20.3 1.3 1 0 0 1 1 1 1 Intermediate filament protein Vps54_N PF10475.9 CCF54734.1 - 0.082 12.2 4.2 1.5 8.0 0.2 2.1 2 0 0 2 2 2 0 Vacuolar-sorting protein 54, of GARP complex Fzo_mitofusin PF04799.13 CCF54734.1 - 0.35 10.4 8.3 1.1 8.8 1.7 2.3 2 0 0 2 2 2 0 fzo-like conserved region BLOC1_2 PF10046.9 CCF54734.1 - 0.46 10.8 13.1 0.34 11.2 0.6 3.5 1 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 ATP-synt_B PF00430.18 CCF54734.1 - 1.1 9.4 28.0 0.06 13.4 9.5 2.4 1 1 1 2 2 2 0 ATP synthase B/B' CF(0) Arm-DNA-bind_5 PF17293.2 CCF54734.1 - 2.1 8.9 6.6 8.6 6.9 1.9 2.7 2 0 0 2 2 2 0 Arm DNA-binding domain YabA PF06156.13 CCF54734.1 - 3.4 8.4 11.7 1.5 9.5 1.5 2.7 2 1 0 2 2 2 0 Initiation control protein YabA YkyA PF10368.9 CCF54734.1 - 5 6.7 21.8 0.1 12.2 10.3 2.5 2 0 0 2 2 2 0 Putative cell-wall binding lipoprotein Ras PF00071.22 CCF54735.1 - 1.6e-58 196.9 0.1 1.9e-58 196.6 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CCF54735.1 - 9.9e-21 74.2 0.0 1.6e-20 73.5 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CCF54735.1 - 4.8e-09 35.9 0.0 5.8e-09 35.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 CCF54735.1 - 8.9e-06 25.4 0.1 1.9e-05 24.3 0.0 1.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 CCF54735.1 - 0.00012 22.0 0.4 0.25 11.2 0.0 2.4 1 1 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 CCF54735.1 - 0.0011 19.0 0.0 0.0018 18.3 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase ATP_bind_1 PF03029.17 CCF54735.1 - 0.0082 15.9 1.0 0.12 12.2 0.0 2.0 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein FeoB_N PF02421.18 CCF54735.1 - 0.011 15.3 0.0 0.03 13.9 0.0 1.9 1 1 0 1 1 1 0 Ferrous iron transport protein B Ser_hydrolase PF06821.13 CCF54735.1 - 0.082 12.8 0.0 0.11 12.3 0.0 1.2 1 0 0 1 1 1 0 Serine hydrolase G-alpha PF00503.20 CCF54735.1 - 0.1 11.7 0.2 3.5 6.7 0.1 2.0 1 1 0 2 2 2 0 G-protein alpha subunit GDA1_CD39 PF01150.17 CCF54738.1 - 6.1e-103 344.7 0.0 8.5e-103 344.2 0.0 1.1 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family Red1 PF07964.11 CCF54738.1 - 0.93 7.7 2.0 1.3 7.1 2.0 1.1 1 0 0 1 1 1 0 Rec10 / Red1 DFRP_C PF16543.5 CCF54739.1 - 1.8e-30 105.3 2.7 1.8e-30 105.3 2.7 3.3 3 0 0 3 3 3 1 DRG Family Regulatory Proteins, Tma46 zf_CCCH_4 PF18345.1 CCF54739.1 - 0.00098 19.1 7.2 0.00098 19.1 7.2 3.3 3 0 0 3 3 3 1 Zinc finger domain zf-CCCH_3 PF15663.5 CCF54739.1 - 0.0036 17.5 4.0 0.073 13.3 0.1 3.1 3 0 0 3 3 3 1 Zinc-finger containing family Torus PF16131.5 CCF54739.1 - 0.0049 17.5 16.4 0.083 13.6 4.8 4.1 2 1 1 3 3 3 2 Torus domain zf-CCCH PF00642.24 CCF54739.1 - 0.0054 16.6 2.1 0.0054 16.6 2.1 2.5 3 0 0 3 3 3 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 CCF54739.1 - 0.018 14.8 11.9 0.03 14.1 2.4 3.3 3 0 0 3 3 3 0 CCCH-type zinc finger PTPS PF01242.19 CCF54739.1 - 0.13 12.3 1.7 4.4 7.3 0.1 2.3 2 0 0 2 2 2 0 6-pyruvoyl tetrahydropterin synthase zf-CCCH_2 PF14608.6 CCF54739.1 - 0.24 11.9 11.7 1.3 9.6 2.9 2.9 2 1 0 2 2 2 0 RNA-binding, Nab2-type zinc finger MAS20 PF02064.15 CCF54739.1 - 3.4 7.8 8.6 30 4.7 0.8 3.4 3 0 0 3 3 3 0 MAS20 protein import receptor Tyr-DNA_phospho PF06087.12 CCF54740.1 - 2.9e-30 105.5 0.0 1.8e-29 102.9 0.0 1.9 1 1 0 1 1 1 1 Tyrosyl-DNA phosphodiesterase SR-25 PF10500.9 CCF54740.1 - 0.43 10.2 15.0 0.71 9.4 15.0 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein NINJA_B PF16136.5 CCF54740.1 - 1.4 9.3 9.2 5.3 7.5 6.5 2.5 2 0 0 2 2 2 0 Putative nuclear localisation signal DUF4201 PF13870.6 CCF54742.1 - 0.0019 17.9 5.0 0.0019 17.9 5.0 2.5 3 0 0 3 3 3 1 Domain of unknown function (DUF4201) LMP PF04778.12 CCF54742.1 - 0.28 11.1 3.7 0.21 11.5 1.3 2.0 2 0 0 2 2 2 0 LMP repeated region Fez1 PF06818.15 CCF54742.1 - 2.1 8.7 23.0 0.27 11.7 8.4 3.0 3 0 0 3 3 3 0 Fez1 ATG16 PF08614.11 CCF54742.1 - 2.3 8.4 29.4 0.29 11.3 12.1 4.0 4 0 0 4 4 4 0 Autophagy protein 16 (ATG16) YabA PF06156.13 CCF54742.1 - 9.8 6.9 11.9 16 6.2 3.5 2.8 2 0 0 2 2 2 0 Initiation control protein YabA DSPc PF00782.20 CCF54743.1 - 1.7e-27 95.9 0.0 4.1e-18 65.5 0.0 3.3 2 1 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 CCF54743.1 - 0.00026 20.6 0.0 0.0073 15.9 0.0 2.2 2 0 0 2 2 2 1 Protein-tyrosine phosphatase Init_tRNA_PT PF04179.12 CCF54743.1 - 0.014 15.6 0.1 0.46 10.8 0.0 2.4 2 0 0 2 2 2 0 Rit1 DUSP-like domain Myotub-related PF06602.14 CCF54743.1 - 0.095 11.6 0.2 5.8 5.7 0.0 2.2 2 0 0 2 2 2 0 Myotubularin-like phosphatase domain DUF2924 PF11149.8 CCF54743.1 - 0.2 12.0 0.0 0.54 10.7 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2924) AIRC PF00731.20 CCF54745.1 - 2.7e-63 212.0 4.1 2.7e-63 212.0 2.1 2.1 2 0 0 2 2 2 1 AIR carboxylase ATP-grasp PF02222.22 CCF54745.1 - 8.6e-54 181.7 0.3 2.8e-53 180.0 0.1 1.9 2 0 0 2 2 2 1 ATP-grasp domain PurK_C PF17769.1 CCF54745.1 - 1.2e-18 66.6 0.0 2.5e-18 65.5 0.0 1.6 1 0 0 1 1 1 1 Phosphoribosylaminoimidazole carboxylase C-terminal domain Dala_Dala_lig_C PF07478.13 CCF54745.1 - 0.00095 18.7 0.0 0.0067 16.0 0.0 2.1 1 1 0 1 1 1 1 D-ala D-ala ligase C-terminus 3HCDH_N PF02737.18 CCF54745.1 - 0.0059 16.5 0.1 0.017 15.0 0.1 1.8 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.21 CCF54745.1 - 0.018 14.3 0.2 0.061 12.6 0.2 1.8 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain 2-Hacid_dh_C PF02826.19 CCF54745.1 - 0.054 12.8 0.4 0.18 11.1 0.2 2.1 2 1 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NmrA PF05368.13 CCF54745.1 - 0.096 12.2 0.2 0.24 10.9 0.2 1.7 1 0 0 1 1 1 0 NmrA-like family CBS PF00571.28 CCF54746.1 - 0.0013 19.1 0.0 0.066 13.7 0.0 3.6 5 0 0 5 5 5 1 CBS domain DASH_Ask1 PF08655.10 CCF54747.1 - 2.8e-28 97.6 0.1 4.8e-28 96.8 0.1 1.4 1 0 0 1 1 1 1 DASH complex subunit Ask1 Pex24p PF06398.11 CCF54748.1 - 1.1e-05 24.7 6.0 1.7e-05 24.0 6.0 1.3 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin IF-2B PF01008.17 CCF54749.1 - 1.6e-58 198.1 0.1 2.6e-52 177.8 0.0 2.0 2 0 0 2 2 2 2 Initiation factor 2 subunit family BUD22 PF09073.10 CCF54750.1 - 0.014 14.8 9.1 0.024 14.0 9.1 1.3 1 0 0 1 1 1 0 BUD22 LCE6A PF15858.5 CCF54750.1 - 0.27 12.0 2.0 0.68 10.7 2.0 1.6 1 0 0 1 1 1 0 Late cornified envelope protein 6A family Apt1 PF10351.9 CCF54750.1 - 0.58 9.0 2.3 0.94 8.3 2.3 1.3 1 0 0 1 1 1 0 Golgi-body localisation protein domain CD99L2 PF12301.8 CCF54750.1 - 4.6 7.5 9.9 0.63 10.3 0.6 2.6 3 0 0 3 3 3 0 CD99 antigen like protein 2 SAM_decarbox PF01536.16 CCF54751.1 - 2.3e-129 431.5 0.0 6.4e-129 430.0 0.0 1.6 2 0 0 2 2 2 1 Adenosylmethionine decarboxylase ThiF PF00899.21 CCF54752.1 - 5.2e-72 242.1 0.5 3.2e-71 239.5 0.0 1.9 2 0 0 2 2 2 1 ThiF family UAE_UbL PF14732.6 CCF54752.1 - 2e-16 60.4 0.8 7.2e-16 58.6 0.8 2.0 1 0 0 1 1 1 1 Ubiquitin/SUMO-activating enzyme ubiquitin-like domain UBA_e1_thiolCys PF10585.9 CCF54752.1 - 5.8e-15 55.9 3.9 1.7e-08 34.7 0.1 2.9 3 0 0 3 3 3 2 Ubiquitin-activating enzyme active site NAD_binding_7 PF13241.6 CCF54752.1 - 0.00029 21.2 0.3 0.00094 19.6 0.0 2.0 2 0 0 2 2 2 1 Putative NAD(P)-binding Shikimate_DH PF01488.20 CCF54752.1 - 0.0017 18.4 0.0 0.0049 16.9 0.0 1.7 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase TFIIE-A_C PF11521.8 CCF54752.1 - 0.03 14.6 1.7 8.1 6.8 0.3 2.7 2 0 0 2 2 2 0 C-terminal general transcription factor TFIIE alpha EF-1_beta_acid PF10587.9 CCF54752.1 - 0.031 14.7 2.3 0.031 14.7 2.3 2.9 3 0 0 3 3 3 0 Eukaryotic elongation factor 1 beta central acidic region Urb2 PF10441.9 CCF54752.1 - 0.15 12.0 0.0 0.31 10.9 0.0 1.5 1 0 0 1 1 1 0 Urb2/Npa2 family Pyr_redox PF00070.27 CCF54752.1 - 0.15 12.6 0.8 0.61 10.7 0.1 2.4 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FIT1_2 PF17357.2 CCF54752.1 - 3.1 8.0 8.4 0.26 11.4 3.4 1.8 2 0 0 2 2 2 0 Facilitor Of iron transport 1 and 2 VHS PF00790.19 CCF54753.1 - 2.9e-41 140.6 0.0 8e-41 139.2 0.0 1.8 1 0 0 1 1 1 1 VHS domain GAT PF03127.14 CCF54753.1 - 1.4e-19 70.1 0.6 5.8e-19 68.2 0.1 2.3 3 1 0 3 3 3 1 GAT domain FHA PF00498.26 CCF54754.1 - 0.0072 16.6 0.1 0.016 15.6 0.1 1.6 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 CCF54754.1 - 0.063 13.6 0.0 0.2 12.0 0.0 1.8 1 0 0 1 1 1 0 Inner membrane component of T3SS, cytoplasmic domain Citrate_bind PF16114.5 CCF54755.1 - 2.1e-88 294.5 0.2 3.9e-88 293.6 0.0 1.6 2 0 0 2 2 2 1 ATP citrate lyase citrate-binding Citrate_synt PF00285.21 CCF54755.1 - 8.4e-19 67.8 0.1 1.4e-16 60.5 0.0 2.7 1 1 1 2 2 2 2 Citrate synthase, C-terminal domain Ligase_CoA PF00549.19 CCF54755.1 - 7.5e-16 58.3 0.1 1.5e-15 57.4 0.1 1.5 1 0 0 1 1 1 1 CoA-ligase CoA_binding PF02629.19 CCF54755.1 - 3.6e-13 50.0 0.0 1.2e-12 48.4 0.0 1.9 2 0 0 2 2 2 1 CoA binding domain ATP-grasp_2 PF08442.10 CCF54755.1 - 4e-07 29.8 0.0 7.5e-07 28.9 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain Succ_CoA_lig PF13607.6 CCF54755.1 - 8.1e-07 28.9 0.0 2.8e-06 27.2 0.0 1.9 2 0 0 2 2 2 1 Succinyl-CoA ligase like flavodoxin domain NAD_binding_10 PF13460.6 CCF54756.1 - 5.6e-06 26.4 0.0 9.8e-06 25.6 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding HIM1 PF08732.10 CCF54756.1 - 0.0034 16.9 0.0 0.0047 16.5 0.0 1.1 1 0 0 1 1 1 1 HIM1 Semialdhyde_dh PF01118.24 CCF54756.1 - 0.01 16.3 0.0 0.026 15.0 0.0 1.7 1 1 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain Epimerase PF01370.21 CCF54756.1 - 0.013 14.9 0.0 0.087 12.3 0.0 2.0 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 CCF54756.1 - 0.13 11.4 0.0 0.56 9.3 0.0 1.8 2 0 0 2 2 2 0 Male sterility protein Asparaginase PF00710.20 CCF54757.1 - 6e-56 189.0 0.0 9.4e-56 188.4 0.0 1.3 1 0 0 1 1 1 1 Asparaginase, N-terminal Asparaginase_C PF17763.1 CCF54757.1 - 4.6e-31 107.4 0.0 9.5e-31 106.4 0.0 1.6 1 0 0 1 1 1 1 Glutaminase/Asparaginase C-terminal domain Ank_2 PF12796.7 CCF54757.1 - 6.6e-07 29.8 0.0 3.9e-06 27.4 0.0 2.3 3 0 0 3 3 3 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 CCF54757.1 - 2.5e-05 24.4 0.0 0.0016 18.7 0.0 3.1 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 CCF54757.1 - 0.00039 20.9 0.0 0.0089 16.6 0.0 2.9 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Ank PF00023.30 CCF54757.1 - 0.0013 19.1 0.1 0.02 15.3 0.0 2.7 2 0 0 2 2 2 1 Ankyrin repeat Ank_3 PF13606.6 CCF54757.1 - 0.0094 16.4 0.1 0.95 10.2 0.0 3.9 5 0 0 5 5 5 1 Ankyrin repeat DUF1744 PF08490.12 CCF54758.1 - 2.2e-134 448.0 0.0 4e-134 447.2 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1744) DNA_pol_B_exo1 PF03104.19 CCF54758.1 - 2.4e-76 257.0 0.0 4.2e-76 256.2 0.0 1.4 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain DNA_pol_B PF00136.21 CCF54758.1 - 1.5e-13 50.2 0.5 1.4e-11 43.8 0.2 3.1 3 1 0 3 3 3 1 DNA polymerase family B DNA_pol_B_exo2 PF10108.9 CCF54758.1 - 1.1e-09 38.2 0.0 2.9e-09 36.9 0.0 1.6 1 0 0 1 1 1 1 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB RNase_H_2 PF13482.6 CCF54758.1 - 3.5e-05 23.9 0.0 0.00012 22.1 0.0 1.9 1 0 0 1 1 1 1 RNase_H superfamily YhdX PF17444.2 CCF54758.1 - 0.11 12.3 0.7 0.33 10.8 0.0 2.1 2 0 0 2 2 2 0 Uncharacterized YhdX-like Glycogen_syn PF05693.13 CCF54759.1 - 0 1114.6 0.0 0 1114.3 0.0 1.0 1 0 0 1 1 1 1 Glycogen synthase Glycos_transf_1 PF00534.20 CCF54759.1 - 1.9e-07 30.8 0.0 6.4e-05 22.5 0.0 2.3 2 0 0 2 2 2 2 Glycosyl transferases group 1 Glyco_transf_5 PF08323.11 CCF54759.1 - 2.3e-07 30.8 0.5 1e-06 28.7 0.5 2.0 1 1 0 1 1 1 1 Starch synthase catalytic domain Glyco_trans_1_4 PF13692.6 CCF54759.1 - 3.1e-06 27.6 0.0 0.0027 18.2 0.0 2.4 2 0 0 2 2 2 2 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 CCF54759.1 - 5.1e-05 23.8 0.2 0.00011 22.7 0.2 1.6 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_transf_4 PF13439.6 CCF54759.1 - 0.00029 20.9 1.4 0.00067 19.7 1.4 1.7 1 1 0 1 1 1 1 Glycosyltransferase Family 4 Dala_Dala_lig_C PF07478.13 CCF54759.1 - 0.18 11.3 0.0 0.42 10.1 0.0 1.6 1 0 0 1 1 1 0 D-ala D-ala ligase C-terminus DBR1 PF05011.13 CCF54761.1 - 7.5e-39 133.3 0.0 1.6e-38 132.3 0.0 1.6 1 0 0 1 1 1 1 Lariat debranching enzyme, C-terminal domain Metallophos PF00149.28 CCF54761.1 - 1.4e-06 29.0 0.1 2.6e-06 28.1 0.1 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 CCF54761.1 - 0.017 15.3 0.0 0.037 14.2 0.0 1.5 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain RA PF00788.23 CCF54762.1 - 1.4e-10 41.7 0.0 7.8e-08 32.9 0.0 3.2 3 0 0 3 3 3 2 Ras association (RalGDS/AF-6) domain SH3_1 PF00018.28 CCF54762.1 - 1e-07 31.4 0.0 2e-07 30.5 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 CCF54762.1 - 0.0067 16.3 0.0 0.013 15.3 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain La PF05383.17 CCF54763.1 - 2.8e-18 65.7 0.0 5e-18 64.9 0.0 1.4 1 0 0 1 1 1 1 La domain E1-E2_ATPase PF00122.20 CCF54766.1 - 4e-31 107.9 0.0 7.8e-31 107.0 0.0 1.5 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.26 CCF54766.1 - 3e-25 89.7 0.0 5.4e-24 85.6 0.0 2.3 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HMA PF00403.26 CCF54766.1 - 8.2e-16 58.2 14.0 3.9e-08 33.6 0.4 4.8 4 1 0 4 4 4 3 Heavy-metal-associated domain HAD PF12710.7 CCF54766.1 - 0.00063 20.2 0.0 0.0015 19.0 0.0 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 CCF54766.1 - 0.094 12.4 0.0 0.18 11.5 0.0 1.4 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase Pro_isomerase PF00160.21 CCF54768.1 - 7.5e-45 153.0 0.1 9e-45 152.8 0.1 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD DUF3336 PF11815.8 CCF54769.1 - 8.4e-45 151.9 1.5 1.3e-44 151.3 1.5 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3336) Patatin PF01734.22 CCF54769.1 - 2.6e-17 63.7 0.3 7.3e-17 62.2 0.0 1.9 2 0 0 2 2 2 1 Patatin-like phospholipase Efg1 PF10153.9 CCF54770.1 - 8.9e-31 106.6 4.9 8.9e-31 106.6 4.9 2.2 2 1 0 2 2 2 1 rRNA-processing protein Efg1 RXT2_N PF08595.11 CCF54770.1 - 1.7 8.7 18.9 0.41 10.7 2.9 2.6 3 0 0 3 3 3 0 RXT2-like, N-terminal FAM176 PF14851.6 CCF54770.1 - 5.5 6.7 15.7 0.83 9.3 0.4 2.9 3 0 0 3 3 3 0 FAM176 family 6PF2K PF01591.18 CCF54771.1 - 1.2e-62 211.2 0.0 1.8e-62 210.5 0.0 1.3 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 CCF54771.1 - 2.1e-23 83.0 0.1 2.9e-21 76.1 0.0 2.3 2 0 0 2 2 2 2 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.6 CCF54771.1 - 0.11 12.7 0.0 0.3 11.3 0.0 1.8 1 0 0 1 1 1 0 AAA domain Thioredoxin PF00085.20 CCF54772.1 - 4.2e-23 81.3 0.0 5.1e-23 81.0 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 CCF54772.1 - 0.0098 16.2 0.2 0.062 13.6 0.1 2.2 2 1 1 3 3 3 1 Thioredoxin-like Thioredoxin_2 PF13098.6 CCF54772.1 - 0.022 15.2 0.0 0.03 14.8 0.0 1.2 1 0 0 1 1 1 0 Thioredoxin-like domain DUF4988 PF16378.5 CCF54772.1 - 0.24 11.1 0.0 0.44 10.2 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function CRC_subunit PF08624.10 CCF54773.1 - 3.5e-44 150.5 0.1 1.1e-43 148.9 0.0 1.8 2 0 0 2 2 2 1 Chromatin remodelling complex Rsc7/Swp82 subunit T2SSK PF03934.13 CCF54774.1 - 0.038 13.4 0.3 0.072 12.5 0.3 1.4 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein K Zn_clus PF00172.18 CCF54775.1 - 3.9e-10 39.7 7.2 6.7e-10 38.9 7.2 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Pkinase PF00069.25 CCF54776.1 - 9.5e-19 67.8 0.0 5.3e-13 48.9 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain WD40 PF00400.32 CCF54776.1 - 3e-16 59.5 9.0 3.5e-08 34.0 0.0 6.2 6 0 0 6 6 6 3 WD domain, G-beta repeat HEAT PF02985.22 CCF54776.1 - 7.9e-12 44.4 4.8 0.048 13.9 0.0 7.1 7 0 0 7 7 7 4 HEAT repeat Pkinase_Tyr PF07714.17 CCF54776.1 - 7.5e-09 35.2 0.0 3.7e-06 26.4 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase HEAT_2 PF13646.6 CCF54776.1 - 3e-05 24.3 2.7 0.57 10.6 0.0 4.5 3 1 2 5 5 5 3 HEAT repeats Kinase-like PF14531.6 CCF54776.1 - 0.00047 19.6 0.0 0.034 13.4 0.0 2.3 2 0 0 2 2 2 1 Kinase-like HEAT_EZ PF13513.6 CCF54776.1 - 0.031 14.8 3.9 11 6.7 0.0 5.2 5 0 0 5 5 5 0 HEAT-like repeat LTV PF04180.14 CCF54776.1 - 0.39 10.4 1.4 2.6 7.7 0.3 2.2 2 0 0 2 2 2 0 Low temperature viability protein CNH PF00780.22 CCF54777.1 - 4.2e-65 220.1 0.0 6.5e-65 219.5 0.0 1.2 1 0 0 1 1 1 1 CNH domain RhoGEF PF00621.20 CCF54777.1 - 1.2e-29 103.9 0.0 2.2e-29 103.0 0.0 1.5 1 0 0 1 1 1 1 RhoGEF domain PH_5 PF15405.6 CCF54777.1 - 7e-08 32.7 0.0 0.00027 21.1 0.0 3.2 2 1 0 2 2 2 2 Pleckstrin homology domain DEP PF00610.21 CCF54777.1 - 0.016 15.3 0.0 0.065 13.3 0.0 2.0 1 1 0 1 1 1 0 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Acetyltransf_1 PF00583.25 CCF54778.1 - 1.9e-13 50.7 0.0 2.5e-08 34.2 0.0 2.1 2 0 0 2 2 2 2 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 CCF54778.1 - 4e-09 36.8 0.0 9.3e-09 35.6 0.0 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 CCF54778.1 - 3.8e-06 26.8 0.0 0.037 14.0 0.0 2.2 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain FR47 PF08445.10 CCF54778.1 - 6.7e-05 22.8 0.1 0.0078 16.2 0.0 2.3 2 0 0 2 2 2 1 FR47-like protein Acetyltransf_13 PF13880.6 CCF54778.1 - 0.041 13.9 0.0 0.072 13.1 0.0 1.3 1 0 0 1 1 1 0 ESCO1/2 acetyl-transferase Acetyltransf_9 PF13527.7 CCF54778.1 - 0.059 13.5 0.3 0.27 11.3 0.1 2.3 2 1 0 2 2 2 0 Acetyltransferase (GNAT) domain Acetyltransf_15 PF17013.5 CCF54778.1 - 0.086 12.3 0.0 0.1 12.0 0.0 1.1 1 0 0 1 1 1 0 Putative acetyl-transferase SPT2 PF08243.11 CCF54779.1 - 8.1e-21 74.6 22.2 8.1e-21 74.6 22.2 6.2 5 2 1 6 6 6 1 SPT2 chromatin protein PRMT5_TIM PF17285.2 CCF54780.1 - 8.8e-67 225.0 0.0 1.2e-66 224.5 0.0 1.2 1 0 0 1 1 1 1 PRMT5 TIM barrel domain PRMT5 PF05185.16 CCF54780.1 - 6.2e-60 202.0 0.0 9.6e-60 201.4 0.0 1.3 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase PRMT5_C PF17286.2 CCF54780.1 - 4.4e-53 179.8 0.0 7.1e-53 179.1 0.0 1.3 1 0 0 1 1 1 1 PRMT5 oligomerisation domain Methyltransf_25 PF13649.6 CCF54780.1 - 0.0048 17.6 0.0 0.011 16.4 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF54780.1 - 0.053 13.3 0.0 0.11 12.3 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_11 PF08241.12 CCF54780.1 - 0.2 12.3 0.0 0.58 10.8 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain CS PF04969.16 CCF54781.1 - 2e-06 28.7 0.0 3.9e-06 27.8 0.0 1.4 1 0 0 1 1 1 1 CS domain RhoGAP PF00620.27 CCF54782.1 - 6.2e-45 152.7 0.1 9.7e-45 152.1 0.1 1.3 1 0 0 1 1 1 1 RhoGAP domain PH PF00169.29 CCF54782.1 - 2.2e-14 53.9 0.0 4e-14 53.0 0.0 1.5 1 0 0 1 1 1 1 PH domain PX PF00787.24 CCF54782.1 - 2.8e-07 30.5 0.0 6.2e-07 29.4 0.0 1.6 1 0 0 1 1 1 1 PX domain PH_11 PF15413.6 CCF54782.1 - 0.011 16.1 0.0 0.032 14.7 0.0 1.8 1 0 0 1 1 1 0 Pleckstrin homology domain UPF0047 PF01894.17 CCF54783.1 - 1.1e-36 125.4 0.0 1.3e-36 125.2 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family UPF0047 rhaM PF05336.13 CCF54783.1 - 0.033 14.2 0.0 0.043 13.9 0.0 1.2 1 0 0 1 1 1 0 L-rhamnose mutarotase RVT_2 PF07727.14 CCF54785.1 - 6.1e-36 124.3 0.0 6.9e-36 124.1 0.0 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) GATA PF00320.27 CCF54787.1 - 4.5e-30 103.0 17.7 6.9e-15 54.4 7.0 2.5 2 0 0 2 2 2 2 GATA zinc finger TF_Zn_Ribbon PF08271.12 CCF54787.1 - 3.1e-06 26.6 6.0 0.011 15.3 0.2 2.5 2 0 0 2 2 2 2 TFIIB zinc-binding Zn-ribbon_8 PF09723.10 CCF54787.1 - 0.0005 20.1 2.5 0.43 10.7 0.3 2.7 2 0 0 2 2 2 2 Zinc ribbon domain Auto_anti-p27 PF06677.12 CCF54787.1 - 0.018 15.2 6.3 1.5 9.1 0.7 2.4 2 0 0 2 2 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) ArfGap PF01412.18 CCF54787.1 - 0.097 12.8 4.6 2 8.5 0.4 2.5 2 0 0 2 2 2 0 Putative GTPase activating protein for Arf zf-RRN7 PF11781.8 CCF54787.1 - 0.11 12.2 7.1 0.13 12.0 0.7 2.4 2 0 0 2 2 2 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 zinc_ribbon_4 PF13717.6 CCF54787.1 - 0.13 12.2 1.3 5.1 7.1 0.1 2.8 2 0 0 2 2 2 0 zinc-ribbon domain OrfB_Zn_ribbon PF07282.11 CCF54787.1 - 0.26 11.2 5.4 0.6 10.1 0.3 2.8 2 0 0 2 2 2 0 Putative transposase DNA-binding domain zf-piccolo PF05715.13 CCF54787.1 - 0.43 10.8 5.5 1.1 9.4 0.1 3.3 4 0 0 4 4 4 0 Piccolo Zn-finger Elf1 PF05129.13 CCF54787.1 - 1.1 9.4 2.8 3 7.9 0.1 2.9 3 1 0 3 3 3 0 Transcription elongation factor Elf1 like DZR PF12773.7 CCF54787.1 - 6.2 6.9 13.0 1.7e+03 -0.9 13.2 3.0 1 1 0 1 1 1 0 Double zinc ribbon Acyl-CoA_dh_1 PF00441.24 CCF54788.1 - 2.5e-48 164.1 3.6 4.6e-48 163.2 3.6 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 CCF54788.1 - 5e-27 93.9 0.3 1.1e-26 92.9 0.3 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 CCF54788.1 - 3.7e-26 92.0 0.2 8.3e-26 90.9 0.2 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 CCF54788.1 - 5.5e-17 62.3 3.8 1.2e-16 61.2 3.8 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain HpaB_N PF11794.8 CCF54788.1 - 3.3e-05 23.7 0.3 0.00012 21.9 0.3 1.9 1 1 0 1 1 1 1 4-hydroxyphenylacetate 3-hydroxylase N terminal Orn_Arg_deC_N PF02784.16 CCF54789.1 - 6.5e-74 248.4 0.0 9.5e-74 247.9 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.22 CCF54789.1 - 7.6e-18 64.6 0.0 9.3e-18 64.3 0.0 1.3 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain AP_endonuc_2 PF01261.24 CCF54789.1 - 0.071 12.5 0.0 0.18 11.2 0.0 1.7 1 0 0 1 1 1 0 Xylose isomerase-like TIM barrel PB1-F2 PF11986.8 CCF54790.1 - 0.039 14.2 0.0 1.9 8.7 0.0 2.3 2 0 0 2 2 2 0 Influenza A Proapoptotic protein RVT_2 PF07727.14 CCF54791.1 - 3.9e-15 56.2 0.0 4.8e-15 55.9 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) FA_desaturase PF00487.24 CCF54793.1 - 2.6e-21 76.6 28.7 5e-20 72.4 28.7 2.2 1 1 0 1 1 1 1 Fatty acid desaturase DUF3474 PF11960.8 CCF54793.1 - 6.2e-05 23.2 0.0 0.00013 22.2 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3474) DUF1604 PF07713.13 CCF54794.1 - 7e-38 128.3 3.2 2e-37 126.9 3.2 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF1604) G-patch PF01585.23 CCF54794.1 - 9.2e-07 28.7 1.2 9.2e-07 28.7 1.2 2.0 2 0 0 2 2 2 1 G-patch domain G-patch_2 PF12656.7 CCF54794.1 - 0.047 13.8 3.1 0.29 11.2 3.1 2.5 1 1 0 1 1 1 0 G-patch domain Forkhead PF00250.18 CCF54796.1 - 6.3e-32 109.7 0.1 3.6e-31 107.3 0.0 2.3 2 0 0 2 2 2 1 Forkhead domain TFIIA PF03153.13 CCF54796.1 - 0.00061 19.9 9.1 0.00061 19.9 9.1 5.2 5 0 0 5 5 5 3 Transcription factor IIA, alpha/beta subunit Aminotran_3 PF00202.21 CCF54797.1 - 2.4e-108 362.4 0.1 3e-108 362.1 0.1 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.21 CCF54797.1 - 5.3e-05 22.5 0.0 0.00092 18.5 0.0 2.1 2 0 0 2 2 2 1 Aminotransferase class I and II NAD_binding_9 PF13454.6 CCF54798.1 - 9.1e-06 25.7 0.0 2.8e-05 24.2 0.0 1.8 2 0 0 2 2 2 1 FAD-NAD(P)-binding Pyr_redox_2 PF07992.14 CCF54798.1 - 0.0002 20.7 0.1 0.0031 16.8 0.0 2.6 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CCF54798.1 - 0.12 12.6 0.1 0.49 10.7 0.0 2.2 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 CCF54798.1 - 0.21 10.8 0.2 22 4.2 0.0 2.9 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase CDP-OH_P_transf PF01066.21 CCF54799.1 - 2.5e-17 63.4 0.3 2.5e-17 63.4 0.3 2.8 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase PLA2_B PF01735.18 CCF54800.1 - 1.9e-126 422.4 12.2 7.7e-98 328.0 4.5 2.2 1 1 1 2 2 2 2 Lysophospholipase catalytic domain Patatin PF01734.22 CCF54800.1 - 0.003 17.8 0.5 0.003 17.8 0.5 1.9 2 0 0 2 2 2 1 Patatin-like phospholipase Actin PF00022.19 CCF54801.1 - 1.9e-91 306.7 0.0 3.8e-90 302.4 0.0 2.0 1 1 0 1 1 1 1 Actin FtsA PF14450.6 CCF54801.1 - 0.015 15.7 0.0 0.11 12.9 0.0 2.5 2 1 0 2 2 2 0 Cell division protein FtsA DPBB_1 PF03330.18 CCF54803.1 - 7.4e-10 39.0 0.1 1.5e-09 38.0 0.1 1.6 1 1 0 1 1 1 1 Lytic transglycolase Barwin PF00967.17 CCF54803.1 - 0.013 15.3 1.5 0.061 13.2 0.0 2.1 1 1 1 2 2 2 0 Barwin family AICARFT_IMPCHas PF01808.18 CCF54804.1 - 2.5e-89 299.6 0.1 4.5e-89 298.8 0.1 1.4 1 0 0 1 1 1 1 AICARFT/IMPCHase bienzyme MGS PF02142.22 CCF54804.1 - 6.8e-22 77.5 0.0 1.5e-21 76.4 0.0 1.6 1 0 0 1 1 1 1 MGS-like domain CBM_25 PF03423.13 CCF54804.1 - 0.17 12.1 1.2 1.4 9.2 0.0 2.6 3 0 0 3 3 3 0 Carbohydrate binding domain (family 25) FAD-oxidase_C PF02913.19 CCF54805.1 - 7.5e-54 183.0 0.0 1e-53 182.5 0.0 1.2 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 CCF54805.1 - 5.6e-32 110.4 0.0 9.5e-32 109.6 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain DUF3918 PF13056.6 CCF54805.1 - 0.14 11.8 0.1 0.33 10.6 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3918) UAA PF08449.11 CCF54806.1 - 1.4e-06 27.7 16.5 1.5e-05 24.3 16.5 2.0 1 1 0 1 1 1 1 UAA transporter family EamA PF00892.20 CCF54806.1 - 2.4e-05 24.5 5.7 2.4e-05 24.5 5.7 2.5 2 1 0 2 2 2 1 EamA-like transporter family Polysacc_synt_4 PF04669.13 CCF54807.1 - 8.8e-19 67.8 1.2 3.1e-17 62.7 1.2 2.0 1 1 0 1 1 1 1 Polysaccharide biosynthesis AAA PF00004.29 CCF54808.1 - 1.2e-96 320.2 0.0 7.5e-47 159.1 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 CCF54808.1 - 2.2e-27 94.6 6.4 3.5e-13 49.1 0.3 3.1 3 0 0 3 3 2 2 AAA+ lid domain CDC48_N PF02359.18 CCF54808.1 - 1.2e-19 70.2 0.2 4.5e-19 68.4 0.1 2.1 2 0 0 2 2 1 1 Cell division protein 48 (CDC48), N-terminal domain RuvB_N PF05496.12 CCF54808.1 - 1.4e-14 54.2 0.1 5.6e-06 26.2 0.0 3.4 2 2 1 3 3 3 2 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 CCF54808.1 - 2e-12 47.5 0.0 3.2e-07 30.6 0.0 2.7 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_33 PF13671.6 CCF54808.1 - 7.8e-12 45.6 0.1 7.2e-06 26.2 0.0 2.8 3 0 0 3 3 2 2 AAA domain CDC48_2 PF02933.17 CCF54808.1 - 1.4e-11 43.9 0.0 3.5e-11 42.7 0.0 1.7 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), domain 2 AAA_16 PF13191.6 CCF54808.1 - 4.3e-11 43.5 1.1 0.0012 19.3 0.0 4.6 3 2 0 3 3 3 2 AAA ATPase domain AAA_5 PF07728.14 CCF54808.1 - 6.9e-11 42.3 0.3 1.7e-05 24.8 0.1 3.3 3 2 0 3 3 2 2 AAA domain (dynein-related subfamily) TIP49 PF06068.13 CCF54808.1 - 3.1e-09 36.5 0.1 0.0015 17.8 0.0 2.6 2 1 0 2 2 2 2 TIP49 P-loop domain AAA_22 PF13401.6 CCF54808.1 - 2.3e-08 34.4 0.2 0.048 13.9 0.0 3.8 2 2 0 2 2 2 2 AAA domain Mg_chelatase PF01078.21 CCF54808.1 - 2e-07 30.6 0.3 0.014 14.8 0.0 2.5 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 CCF54808.1 - 5.6e-07 29.9 0.0 0.018 15.4 0.0 2.7 2 0 0 2 2 2 2 RNA helicase ATPase PF06745.13 CCF54808.1 - 8.2e-07 28.6 0.3 0.51 9.6 0.0 3.4 3 0 0 3 3 3 2 KaiC IstB_IS21 PF01695.17 CCF54808.1 - 9.7e-07 28.7 0.0 0.024 14.4 0.0 2.5 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_18 PF13238.6 CCF54808.1 - 1e-06 29.3 0.0 0.024 15.2 0.0 2.9 2 0 0 2 2 2 2 AAA domain AAA_7 PF12775.7 CCF54808.1 - 2.9e-06 26.9 0.0 0.026 14.0 0.0 2.7 2 1 0 2 2 2 2 P-loop containing dynein motor region AAA_25 PF13481.6 CCF54808.1 - 3.3e-06 26.8 0.3 0.64 9.6 0.0 3.5 2 1 1 3 3 3 2 AAA domain Parvo_NS1 PF01057.17 CCF54808.1 - 3.5e-06 26.3 0.1 0.012 14.7 0.0 2.2 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 AAA_14 PF13173.6 CCF54808.1 - 5e-06 26.6 0.0 0.018 15.1 0.0 2.6 2 0 0 2 2 2 2 AAA domain Vps4_C PF09336.10 CCF54808.1 - 5e-06 26.4 0.0 0.00011 22.1 0.0 2.9 3 0 0 3 3 2 1 Vps4 C terminal oligomerisation domain Sigma54_activat PF00158.26 CCF54808.1 - 1.5e-05 24.8 0.0 0.35 10.6 0.0 3.0 2 1 0 2 2 2 2 Sigma-54 interaction domain AAA_24 PF13479.6 CCF54808.1 - 1.6e-05 24.7 0.0 0.2 11.3 0.0 2.9 3 0 0 3 3 2 2 AAA domain AAA_28 PF13521.6 CCF54808.1 - 1.9e-05 25.0 0.1 0.14 12.4 0.0 3.0 3 0 0 3 3 2 2 AAA domain Bac_DnaA PF00308.18 CCF54808.1 - 2e-05 24.6 0.0 0.074 12.9 0.0 2.4 2 0 0 2 2 2 2 Bacterial dnaA protein DUF815 PF05673.13 CCF54808.1 - 2.2e-05 23.8 0.0 0.011 14.9 0.0 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF815) ABC_tran PF00005.27 CCF54808.1 - 4.9e-05 23.9 0.0 0.24 11.9 0.0 3.5 2 1 0 2 2 2 1 ABC transporter PhoH PF02562.16 CCF54808.1 - 0.00012 21.6 0.2 0.47 9.9 0.0 2.4 2 0 0 2 2 2 2 PhoH-like protein TsaE PF02367.17 CCF54808.1 - 0.00014 21.9 0.0 0.25 11.4 0.0 2.4 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_17 PF13207.6 CCF54808.1 - 0.00023 21.6 0.4 0.63 10.5 0.0 3.0 3 0 0 3 3 2 2 AAA domain AAA_3 PF07726.11 CCF54808.1 - 0.00023 21.0 0.0 0.96 9.3 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) ResIII PF04851.15 CCF54808.1 - 0.00023 21.2 0.0 0.1 12.6 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_11 PF13086.6 CCF54808.1 - 0.00025 20.9 0.2 1 9.1 0.0 2.8 3 0 0 3 3 3 2 AAA domain DUF2075 PF09848.9 CCF54808.1 - 0.00037 19.8 0.0 0.49 9.6 0.0 2.4 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2075) ATPase_2 PF01637.18 CCF54808.1 - 0.00091 19.2 0.1 2.8 7.8 0.0 3.1 2 1 0 2 2 2 1 ATPase domain predominantly from Archaea NACHT PF05729.12 CCF54808.1 - 0.0016 18.4 0.1 1.1 9.2 0.0 3.0 3 0 0 3 3 3 1 NACHT domain AAA_30 PF13604.6 CCF54808.1 - 0.0021 17.8 0.6 2.5 7.8 0.1 2.6 2 0 0 2 2 2 2 AAA domain Sigma54_activ_2 PF14532.6 CCF54808.1 - 0.0023 18.1 0.0 1.4 9.0 0.0 2.6 2 0 0 2 2 2 1 Sigma-54 interaction domain Zeta_toxin PF06414.12 CCF54808.1 - 0.0046 16.3 0.0 2.6 7.3 0.0 2.7 2 0 0 2 2 2 1 Zeta toxin NB-ARC PF00931.22 CCF54808.1 - 0.0048 16.1 0.0 0.82 8.8 0.0 2.4 2 0 0 2 2 2 1 NB-ARC domain Viral_helicase1 PF01443.18 CCF54808.1 - 0.0059 16.4 0.0 0.28 10.9 0.0 2.3 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase AAA_19 PF13245.6 CCF54808.1 - 0.0063 16.8 2.2 3.5 7.9 0.0 3.5 3 1 0 4 4 3 0 AAA domain Molydop_binding PF01568.21 CCF54808.1 - 0.014 15.4 0.0 0.059 13.4 0.0 2.0 1 1 0 1 1 1 0 Molydopterin dinucleotide binding domain NTPase_1 PF03266.15 CCF54808.1 - 0.027 14.4 0.4 4.2 7.3 0.0 3.3 3 0 0 3 3 3 0 NTPase Zot PF05707.12 CCF54808.1 - 0.044 13.4 0.0 2 8.0 0.0 2.8 2 1 0 2 2 2 0 Zonular occludens toxin (Zot) IPT PF01745.16 CCF54808.1 - 0.048 13.1 0.0 2.4 7.5 0.0 2.2 2 0 0 2 2 2 0 Isopentenyl transferase Cytidylate_kin PF02224.18 CCF54808.1 - 0.053 13.3 0.0 8.4 6.1 0.0 2.8 2 0 0 2 2 2 0 Cytidylate kinase T2SSE PF00437.20 CCF54808.1 - 0.078 12.0 0.0 1.2 8.1 0.0 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein KAP_NTPase PF07693.14 CCF54808.1 - 0.078 12.2 0.0 0.55 9.4 0.0 2.2 2 1 0 2 2 2 0 KAP family P-loop domain UFD1 PF03152.14 CCF54808.1 - 0.095 12.2 0.0 0.21 11.0 0.0 1.6 1 1 0 1 1 1 0 Ubiquitin fusion degradation protein UFD1 PIF1 PF05970.14 CCF54808.1 - 0.18 10.9 0.1 7.5 5.6 0.0 2.9 4 0 0 4 4 3 0 PIF1-like helicase SHR3_chaperone PF08229.11 CCF54809.1 - 2.6e-47 160.2 0.1 3.2e-47 160.0 0.1 1.1 1 0 0 1 1 1 1 ER membrane protein SH3 Neurensin PF14927.6 CCF54809.1 - 0.037 13.7 0.5 0.14 11.9 0.4 2.0 1 1 0 1 1 1 0 Neurensin CD36 PF01130.21 CCF54809.1 - 0.22 10.0 0.1 0.35 9.4 0.1 1.2 1 0 0 1 1 1 0 CD36 family Clat_adaptor_s PF01217.20 CCF54810.1 - 4e-49 166.2 0.4 7.1e-36 123.3 0.4 2.0 2 0 0 2 2 2 2 Clathrin adaptor complex small chain Mito_carr PF00153.27 CCF54811.1 - 6.5e-67 221.5 5.2 7.5e-22 77.1 0.1 3.0 2 1 1 3 3 3 3 Mitochondrial carrier protein DUF1282 PF06930.12 CCF54811.1 - 0.0097 15.7 0.8 0.37 10.6 0.1 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF1282) PBP-Tp47_a PF14889.6 CCF54811.1 - 0.07 12.8 0.1 0.11 12.2 0.1 1.4 1 0 0 1 1 1 0 Penicillin-binding protein Tp47 domain a Ribosomal_S13 PF00416.22 CCF54812.1 - 2.4e-53 179.9 2.6 2.8e-53 179.7 2.6 1.0 1 0 0 1 1 1 1 Ribosomal protein S13/S18 FbpA PF05833.11 CCF54812.1 - 0.0081 15.0 0.0 0.0086 14.9 0.0 1.2 1 0 0 1 1 1 1 Fibronectin-binding protein A N-terminus (FbpA) DUF2746 PF10874.8 CCF54812.1 - 0.012 16.0 0.0 0.019 15.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2746) dTDP_sugar_isom PF00908.17 CCF54813.1 - 0.079 12.6 0.0 0.18 11.5 0.0 1.5 1 0 0 1 1 1 0 dTDP-4-dehydrorhamnose 3,5-epimerase TBX PF12598.8 CCF54813.1 - 0.31 11.9 0.1 0.31 11.9 0.1 1.9 2 0 0 2 2 2 0 T-box transcription factor CPSase_L_D2 PF02786.17 CCF54814.1 - 7.1e-82 274.0 0.1 1.1e-81 273.3 0.1 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain PYC_OADA PF02436.18 CCF54814.1 - 1.8e-69 233.5 0.0 3e-69 232.8 0.0 1.4 1 0 0 1 1 1 1 Conserved carboxylase domain Biotin_carb_N PF00289.22 CCF54814.1 - 1.7e-39 134.8 0.0 3.8e-39 133.6 0.0 1.6 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 CCF54814.1 - 5.3e-30 103.7 0.0 1.2e-29 102.5 0.0 1.7 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain HMGL-like PF00682.19 CCF54814.1 - 1.4e-29 103.5 0.0 2.9e-29 102.5 0.0 1.5 1 0 0 1 1 1 1 HMGL-like Biotin_lipoyl PF00364.22 CCF54814.1 - 1.2e-15 57.1 0.8 2.6e-15 56.0 0.8 1.5 1 0 0 1 1 1 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.6 CCF54814.1 - 1.2e-14 53.8 0.1 6.2e-07 29.2 0.1 2.5 1 1 1 2 2 2 2 Biotin-lipoyl like Dala_Dala_lig_C PF07478.13 CCF54814.1 - 2.1e-09 37.3 0.0 4e-09 36.3 0.0 1.4 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 CCF54814.1 - 2.4e-07 30.5 0.0 5.7e-07 29.3 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain HlyD_3 PF13437.6 CCF54814.1 - 1.6e-05 25.5 0.1 0.39 11.5 0.0 2.8 2 0 0 2 2 2 2 HlyD family secretion protein HlyD_D23 PF16576.5 CCF54814.1 - 6.4e-05 22.3 0.1 0.0095 15.2 0.0 2.4 1 1 1 2 2 2 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion ATP-grasp_3 PF02655.14 CCF54814.1 - 0.00011 22.3 0.0 0.00023 21.3 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain GARS_A PF01071.19 CCF54814.1 - 0.00042 20.2 0.0 0.00081 19.2 0.0 1.5 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain RimK PF08443.11 CCF54814.1 - 0.0012 18.5 0.0 0.004 16.8 0.0 1.9 1 1 0 1 1 1 1 RimK-like ATP-grasp domain ATP-grasp_4 PF13535.6 CCF54814.1 - 0.0013 18.3 0.0 0.0025 17.4 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain NQRA PF05896.11 CCF54814.1 - 0.027 13.9 0.1 0.048 13.1 0.1 1.4 1 0 0 1 1 1 0 Na(+)-translocating NADH-quinone reductase subunit A (NQRA) DUF2118 PF09891.9 CCF54814.1 - 0.028 14.4 0.3 2 8.4 0.2 2.4 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2118) ATPgrasp_ST PF14397.6 CCF54814.1 - 0.042 13.1 0.0 0.087 12.1 0.0 1.4 1 0 0 1 1 1 0 Sugar-transfer associated ATP-grasp GCV_H PF01597.19 CCF54814.1 - 0.31 10.9 0.6 3.3 7.6 0.3 2.7 2 1 1 3 3 3 0 Glycine cleavage H-protein PRCC PF10253.9 CCF54815.1 - 0.15 12.9 1.8 0.16 12.8 1.8 1.1 1 0 0 1 1 1 0 Mitotic checkpoint regulator, MAD2B-interacting MFS_1 PF07690.16 CCF54816.1 - 1.5e-33 116.2 32.1 1.1e-31 110.0 29.9 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF54816.1 - 2.8e-10 39.6 11.1 7.2e-10 38.3 11.0 1.8 1 1 0 1 1 1 1 Sugar (and other) transporter TRI12 PF06609.13 CCF54816.1 - 0.0047 15.4 5.3 0.0087 14.5 5.3 1.4 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) UL42 PF17638.2 CCF54816.1 - 0.021 14.8 0.1 0.072 13.1 0.1 1.9 1 0 0 1 1 1 0 HCMV UL42 DUF4191 PF13829.6 CCF54816.1 - 5.5 6.3 11.8 1.1 8.5 0.3 3.4 4 0 0 4 4 4 0 Domain of unknown function (DUF4191) TFA2_Winged_2 PF18121.1 CCF54817.1 - 0.051 13.3 0.0 0.15 11.8 0.0 1.7 1 0 0 1 1 1 0 TFA2 Winged helix domain 2 SURF1 PF02104.15 CCF54818.1 - 8.3e-45 153.2 0.0 1.1e-44 152.8 0.0 1.1 1 0 0 1 1 1 1 SURF1 family UAA PF08449.11 CCF54819.1 - 2.2e-76 257.0 3.6 6.6e-76 255.4 3.6 1.6 1 1 0 1 1 1 1 UAA transporter family PUNUT PF16913.5 CCF54819.1 - 0.00064 19.0 0.1 0.00064 19.0 0.1 3.0 2 1 0 3 3 3 1 Purine nucleobase transmembrane transport NrsF PF06532.11 CCF54819.1 - 0.031 14.0 0.0 0.031 14.0 0.0 2.3 2 1 0 2 2 2 0 Negative regulator of sigma F Nuc_sug_transp PF04142.15 CCF54819.1 - 0.38 9.9 4.8 0.083 12.0 0.5 2.0 2 1 0 2 2 2 0 Nucleotide-sugar transporter DUF1772 PF08592.11 CCF54819.1 - 1.8 8.8 7.4 3 8.2 0.1 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF1772) IPK PF03770.16 CCF54822.1 - 9.9e-50 169.1 0.0 1.7e-49 168.4 0.0 1.4 1 0 0 1 1 1 1 Inositol polyphosphate kinase Kelch_6 PF13964.6 CCF54823.1 - 9.7e-11 41.6 0.5 0.067 13.5 0.0 4.9 4 0 0 4 4 4 3 Kelch motif Kelch_4 PF13418.6 CCF54823.1 - 4.3e-10 39.4 0.0 0.0085 16.1 0.0 4.0 3 1 0 3 3 3 3 Galactose oxidase, central domain Kelch_3 PF13415.6 CCF54823.1 - 1.6e-07 31.4 3.4 9.5e-06 25.8 0.0 4.9 5 0 0 5 5 5 1 Galactose oxidase, central domain Kelch_5 PF13854.6 CCF54823.1 - 2.3e-07 30.7 0.0 0.012 15.6 0.0 3.6 3 0 0 3 3 3 2 Kelch motif Kelch_2 PF07646.15 CCF54823.1 - 4.3e-05 23.3 0.1 4.3 7.5 0.0 4.8 4 1 0 4 4 4 2 Kelch motif AMP-binding PF00501.28 CCF54825.1 - 6.3e-79 265.5 0.0 2.3e-78 263.7 0.0 1.7 1 1 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 CCF54825.1 - 6e-08 33.6 0.3 1.4e-07 32.4 0.3 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain RNase_PH PF01138.21 CCF54826.1 - 1.8e-31 109.4 0.1 3.6e-31 108.4 0.0 1.5 2 0 0 2 2 2 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 CCF54826.1 - 0.0017 18.3 0.1 0.0052 16.8 0.0 1.8 2 0 0 2 2 2 1 3' exoribonuclease family, domain 2 Cullin PF00888.22 CCF54827.1 - 1.1e-10 40.8 0.0 3.5e-10 39.1 0.0 1.7 2 0 0 2 2 2 1 Cullin family DUF1514 PF07438.11 CCF54827.1 - 0.1 12.5 0.1 0.23 11.4 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1514) SWIRM-assoc_2 PF16496.5 CCF54827.1 - 0.53 9.1 3.3 0.82 8.5 3.3 1.3 1 0 0 1 1 1 0 SWIRM-associated domain at the N-terminal Proteasome PF00227.26 CCF54828.1 - 3.7e-33 114.6 0.0 1.1e-32 113.1 0.0 1.6 1 1 0 1 1 1 1 Proteasome subunit Condensation PF00668.20 CCF54829.1 - 0.16 10.6 0.4 0.82 8.3 0.1 2.2 3 0 0 3 3 3 0 Condensation domain TLV_coat PF00429.19 CCF54830.1 - 0.27 9.8 0.0 0.4 9.3 0.0 1.1 1 0 0 1 1 1 0 ENV polyprotein (coat polyprotein) DUF3712 PF12505.8 CCF54832.1 - 1.6e-101 335.3 38.9 6.2e-23 81.4 0.0 8.6 10 0 0 10 10 10 6 Protein of unknown function (DUF3712) LEA_2 PF03168.13 CCF54832.1 - 1.7e-05 25.3 9.9 1.5 9.4 0.1 7.5 8 0 0 8 8 8 2 Late embryogenesis abundant protein zf-XS PF03470.14 CCF54833.1 - 0.08 13.2 0.1 0.13 12.5 0.1 1.3 1 0 0 1 1 1 0 XS zinc finger domain RabGAP-TBC PF00566.18 CCF54834.1 - 5e-50 170.1 0.1 8e-50 169.5 0.1 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain GRAM PF02893.20 CCF54834.1 - 7.8e-06 25.7 0.0 1.7e-05 24.7 0.0 1.5 1 0 0 1 1 1 1 GRAM domain EF-hand_7 PF13499.6 CCF54834.1 - 0.2 12.1 1.1 4.7 7.7 0.1 3.0 3 0 0 3 3 3 0 EF-hand domain pair Meth_synt_2 PF01717.18 CCF54835.1 - 8.7e-151 501.7 0.0 1.3e-142 474.8 0.0 3.1 3 0 0 3 3 3 3 Cobalamin-independent synthase, Catalytic domain Meth_synt_1 PF08267.12 CCF54835.1 - 2.5e-119 398.4 0.0 6.2e-113 377.4 0.1 2.8 3 0 0 3 3 3 2 Cobalamin-independent synthase, N-terminal domain URO-D PF01208.17 CCF54835.1 - 0.0019 17.4 0.0 0.24 10.5 0.0 2.7 3 0 0 3 3 3 2 Uroporphyrinogen decarboxylase (URO-D) SHOCT PF09851.9 CCF54835.1 - 0.063 13.0 1.2 0.14 11.9 1.2 1.6 1 0 0 1 1 1 0 Short C-terminal domain DUF726 PF05277.12 CCF54836.1 - 7.1e-57 192.9 0.6 1.1e-56 192.2 0.6 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF726) Abhydrolase_6 PF12697.7 CCF54836.1 - 0.0016 19.0 0.0 0.0051 17.4 0.0 1.8 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF3089 PF11288.8 CCF54836.1 - 0.04 13.4 0.0 0.078 12.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3089) Hydrolase_4 PF12146.8 CCF54836.1 - 0.058 12.7 0.0 0.14 11.4 0.0 1.5 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 CCF54836.1 - 0.099 12.3 0.0 0.2 11.3 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold NRBF2 PF08961.10 CCF54837.1 - 0.0022 17.6 3.3 0.0022 17.6 3.3 2.1 2 0 0 2 2 2 1 Nuclear receptor-binding factor 2, autophagy regulator DUF1481 PF07356.12 CCF54837.1 - 0.23 11.2 6.8 0.18 11.5 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1481) DUF5094 PF17015.5 CCF54837.1 - 0.45 10.6 3.3 0.86 9.7 3.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5094) DivIC PF04977.15 CCF54837.1 - 0.52 10.1 13.8 0.84 9.4 4.9 2.8 2 1 0 2 2 2 0 Septum formation initiator RBR PF17208.3 CCF54837.1 - 1.5 9.6 6.8 0.23 12.2 1.0 2.8 2 1 0 2 2 2 0 RNA binding Region TSC22 PF01166.18 CCF54837.1 - 5.3 7.4 8.0 0.14 12.4 1.1 1.9 2 0 0 2 2 2 0 TSC-22/dip/bun family YabA PF06156.13 CCF54837.1 - 7.9 7.2 6.2 12 6.6 2.1 2.4 2 0 0 2 2 2 0 Initiation control protein YabA GTP_EFTU PF00009.27 CCF54838.1 - 1.6e-53 181.1 0.0 2.3e-53 180.6 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 CCF54838.1 - 5.9e-41 139.3 0.0 1.3e-40 138.2 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 CCF54838.1 - 2.3e-13 50.3 3.0 2.4e-13 50.3 1.2 2.1 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 CCF54838.1 - 0.0013 18.8 0.2 0.03 14.4 0.2 2.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase FlpD PF02662.16 CCF54838.1 - 0.048 13.6 0.0 0.17 11.9 0.0 1.9 2 0 0 2 2 2 0 Methyl-viologen-reducing hydrogenase, delta subunit TAFII55_N PF04658.13 CCF54839.1 - 8.4e-53 178.4 0.6 1.9e-52 177.2 0.0 1.9 2 0 0 2 2 2 1 TAFII55 protein conserved region zf-C4H2 PF10146.9 CCF54839.1 - 2.2 8.5 14.4 0.78 10.0 11.3 1.8 2 0 0 2 2 2 0 Zinc finger-containing protein Ribosomal_L32e PF01655.18 CCF54840.1 - 2.2e-49 166.4 1.3 2.6e-49 166.1 1.3 1.0 1 0 0 1 1 1 1 Ribosomal protein L32 Ribosomal_L13 PF00572.18 CCF54841.1 - 9.9e-13 48.4 1.6 1.7e-10 41.2 0.0 2.6 2 1 1 3 3 3 2 Ribosomal protein L13 ubiquitin PF00240.23 CCF54843.1 - 9.9e-21 73.3 0.2 1.5e-20 72.7 0.2 1.2 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 CCF54843.1 - 2.6e-09 36.8 0.3 4.1e-09 36.1 0.3 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 CCF54843.1 - 5.1e-06 27.0 0.0 9.7e-06 26.1 0.0 1.4 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain UBA PF00627.31 CCF54843.1 - 3.2e-05 23.7 0.1 0.00012 21.9 0.1 2.1 1 0 0 1 1 1 1 UBA/TS-N domain Rad60-SLD_2 PF13881.6 CCF54843.1 - 0.00028 21.0 0.0 0.00052 20.1 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_4 PF18036.1 CCF54843.1 - 0.0051 16.8 0.4 0.65 10.1 0.1 2.2 1 1 1 2 2 2 1 Ubiquitin-like domain TBK1_ULD PF18396.1 CCF54843.1 - 0.032 14.2 0.0 0.06 13.3 0.0 1.3 1 0 0 1 1 1 0 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_2 PF14560.6 CCF54843.1 - 0.073 13.5 0.2 0.2 12.1 0.2 1.8 1 1 0 1 1 1 0 Ubiquitin-like domain GerD PF17898.1 CCF54843.1 - 0.67 9.9 13.9 7.6 6.5 13.9 2.3 1 1 0 1 1 1 0 Spore germination GerD central core domain Sld7_C PF18596.1 CCF54844.1 - 0.053 13.7 0.0 0.094 12.9 0.0 1.4 1 0 0 1 1 1 0 Sld7 C-terminal domain DUF1192 PF06698.11 CCF54845.1 - 0.017 15.1 0.7 0.017 15.1 0.7 13.3 14 1 0 14 14 14 0 Protein of unknown function (DUF1192) DUF3800 PF12686.7 CCF54845.1 - 0.1 13.3 0.0 35 5.0 0.0 4.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3800) Pox_A_type_inc PF04508.12 CCF54845.1 - 0.12 12.3 0.0 0.12 12.3 0.0 7.1 8 0 0 8 8 8 0 Viral A-type inclusion protein repeat Zn_clus PF00172.18 CCF54846.1 - 0.0016 18.6 11.4 0.0026 17.8 11.4 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain FRG1 PF06229.12 CCF54847.1 - 7e-19 68.3 5.9 2.2e-17 63.4 5.9 3.2 1 1 0 1 1 1 1 FRG1-like domain Fascin PF06268.13 CCF54847.1 - 0.0009 19.4 0.2 0.44 10.8 0.0 2.4 1 1 1 2 2 2 2 Fascin domain DUF4504 PF14953.6 CCF54848.1 - 1.5e-13 50.7 0.0 2.8e-12 46.6 0.0 2.1 1 1 0 1 1 1 1 Domain of unknown function (DUF4504) Metal_resist PF13801.6 CCF54848.1 - 0.024 14.8 0.6 0.06 13.5 0.6 1.6 1 0 0 1 1 1 0 Heavy-metal resistance Transposase_mut PF00872.18 CCF54848.1 - 0.12 11.2 0.1 0.23 10.3 0.1 1.5 1 1 0 1 1 1 0 Transposase, Mutator family Mito_carr PF00153.27 CCF54849.1 - 2.2e-65 216.6 4.9 2.2e-24 85.2 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Fuseless PF15993.5 CCF54849.1 - 0.072 12.3 0.1 0.21 10.7 0.0 1.7 2 0 0 2 2 2 0 Fuseless SUZ PF12752.7 CCF54850.1 - 2.2e-13 50.7 3.0 2.2e-13 50.7 3.0 2.6 3 0 0 3 3 3 1 SUZ domain PBP1_TM PF14812.6 CCF54850.1 - 1.9 8.9 8.4 0.18 12.2 3.5 1.7 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal NTP_transf_2 PF01909.23 CCF54851.1 - 8.7e-06 25.9 0.0 2e-05 24.8 0.0 1.6 1 0 0 1 1 1 1 Nucleotidyltransferase domain PAP_assoc PF03828.19 CCF54851.1 - 0.037 14.2 0.0 0.87 9.8 0.0 2.6 2 0 0 2 2 2 0 Cid1 family poly A polymerase Polbeta PF18765.1 CCF54851.1 - 0.098 12.8 0.0 0.31 11.2 0.0 1.7 1 0 0 1 1 1 0 Polymerase beta, Nucleotidyltransferase Bul1_N PF04425.12 CCF54851.1 - 7.1 5.3 7.9 1.9 7.2 4.2 1.8 2 0 0 2 2 2 0 Bul1 N terminus DNA_pol3_delta2 PF13177.6 CCF54853.1 - 5.9e-10 39.2 0.0 1.2e-09 38.1 0.0 1.6 1 1 0 1 1 1 1 DNA polymerase III, delta subunit Rep_fac_C PF08542.11 CCF54853.1 - 1.1e-05 25.8 0.5 0.00014 22.2 0.0 2.5 3 0 0 3 3 3 1 Replication factor C C-terminal domain AAA PF00004.29 CCF54853.1 - 7.4e-05 23.2 0.1 0.00023 21.6 0.1 1.8 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 CCF54853.1 - 0.00021 21.2 0.0 0.00039 20.4 0.0 1.4 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_22 PF13401.6 CCF54853.1 - 0.0026 18.0 0.1 0.01 16.1 0.1 2.0 1 1 0 1 1 1 1 AAA domain DNA_pol3_delta PF06144.13 CCF54853.1 - 0.0051 16.6 0.1 0.0093 15.8 0.1 1.5 1 0 0 1 1 1 1 DNA polymerase III, delta subunit AAA_24 PF13479.6 CCF54853.1 - 0.023 14.4 0.0 0.049 13.3 0.0 1.5 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.6 CCF54853.1 - 0.03 14.7 0.0 0.12 12.7 0.0 2.2 1 1 0 1 1 1 0 AAA ATPase domain RuvB_N PF05496.12 CCF54853.1 - 0.045 13.5 0.0 0.59 9.9 0.0 2.2 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain ABC_tran PF00005.27 CCF54853.1 - 0.11 13.0 0.0 0.33 11.5 0.0 1.8 1 1 0 1 1 1 0 ABC transporter AAA_5 PF07728.14 CCF54853.1 - 0.13 12.3 0.0 0.26 11.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Rpr2 PF04032.16 CCF54853.1 - 0.19 12.1 0.1 0.66 10.3 0.0 1.9 2 0 0 2 2 2 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain DEAD PF00270.29 CCF54855.1 - 6.4e-37 127.0 0.0 1.2e-36 126.1 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CCF54855.1 - 9.1e-24 83.9 0.0 1.4e-22 80.2 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CCF54855.1 - 2e-07 31.1 0.0 1.1e-06 28.8 0.0 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 CCF54855.1 - 0.0054 17.1 0.0 0.017 15.5 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 CCF54855.1 - 0.024 14.9 0.1 1.7 8.9 0.0 2.7 2 0 0 2 2 2 0 AAA domain BUD22 PF09073.10 CCF54855.1 - 8.4 5.6 35.8 19 4.4 35.8 1.6 1 1 0 1 1 1 0 BUD22 Tfb4 PF03850.14 CCF54856.1 - 1.3e-73 247.9 0.9 4.6e-72 242.8 0.9 2.2 1 1 0 1 1 1 1 Transcription factor Tfb4 IGR PF09597.10 CCF54857.1 - 3.4e-13 49.5 0.9 6.7e-13 48.5 0.9 1.5 1 1 0 1 1 1 1 IGR protein motif 60KD_IMP PF02096.20 CCF54858.1 - 1.7e-10 41.1 0.0 3.4e-10 40.1 0.0 1.5 1 1 0 1 1 1 1 60Kd inner membrane protein ResIII PF04851.15 CCF54859.1 - 1.1e-19 71.1 0.0 2.8e-19 69.8 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 CCF54859.1 - 4.2e-19 68.9 0.0 8.5e-19 67.9 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 CCF54859.1 - 1.7e-15 57.3 0.0 5.2e-15 55.6 0.0 1.9 1 0 0 1 1 1 1 DEAD/DEAH box helicase DSS1_SEM1 PF05160.13 CCF54859.1 - 2.2 8.4 13.1 21 5.3 0.0 4.6 4 0 0 4 4 4 0 DSS1/SEM1 family EF-hand_7 PF13499.6 CCF54860.1 - 2.2e-28 98.5 11.2 3.6e-14 53.0 2.8 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 CCF54860.1 - 2.6e-26 89.1 15.3 1.9e-09 36.4 0.2 4.2 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 CCF54860.1 - 8e-24 81.5 10.5 2.7e-08 33.1 0.1 4.5 4 1 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 CCF54860.1 - 9.4e-17 60.6 10.7 5.5e-10 38.9 1.7 3.3 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_9 PF14658.6 CCF54860.1 - 6.1e-11 42.5 1.1 0.00014 22.1 0.2 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 CCF54860.1 - 1.1e-10 40.4 14.1 1.3e-05 24.4 0.1 4.3 4 0 0 4 4 4 2 EF hand EF-hand_4 PF12763.7 CCF54860.1 - 5.2e-08 32.8 3.5 0.00079 19.3 0.1 2.5 2 1 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand Caleosin PF05042.13 CCF54860.1 - 0.00013 22.0 2.0 0.06 13.3 0.0 3.6 1 1 1 3 3 3 1 Caleosin related protein EF-hand_14 PF17959.1 CCF54860.1 - 0.012 15.9 3.3 0.64 10.4 0.4 2.4 2 0 0 2 2 2 0 EF-hand domain HTH_40 PF14493.6 CCF54860.1 - 0.014 15.9 0.2 3.3 8.2 0.0 2.3 2 0 0 2 2 2 0 Helix-turn-helix domain SurA_N_2 PF13623.6 CCF54860.1 - 0.032 14.1 1.7 0.46 10.3 0.6 2.4 1 1 1 2 2 2 0 SurA N-terminal domain SPARC_Ca_bdg PF10591.9 CCF54860.1 - 0.038 14.3 4.5 2.4 8.5 0.6 2.2 1 1 1 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region DUF1636 PF07845.11 CCF54860.1 - 0.056 13.9 0.0 2.1 8.8 0.0 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF1636) PhetRS_B1 PF18262.1 CCF54860.1 - 0.057 13.6 1.2 0.18 12.1 1.2 1.8 1 0 0 1 1 1 0 Phe-tRNA synthetase beta subunit B1 domain G-patch PF01585.23 CCF54861.1 - 6.4e-12 45.2 0.7 1.6e-11 43.9 0.7 1.7 1 0 0 1 1 1 1 G-patch domain R3H PF01424.22 CCF54861.1 - 4.1e-09 36.3 0.0 8e-09 35.4 0.0 1.5 1 0 0 1 1 1 1 R3H domain G-patch_2 PF12656.7 CCF54861.1 - 4.7e-05 23.4 0.8 0.00021 21.3 0.8 2.3 1 0 0 1 1 1 1 G-patch domain SPT_ssu-like PF11779.8 CCF54862.1 - 7.6e-15 54.3 5.5 1.1e-14 53.7 5.5 1.3 1 0 0 1 1 1 1 Small subunit of serine palmitoyltransferase-like Rubella_E2 PF05749.11 CCF54862.1 - 4.3 6.7 7.7 0.17 11.3 0.3 1.9 2 0 0 2 2 2 0 Rubella membrane glycoprotein E2 TPR_2 PF07719.17 CCF54863.1 - 0.023 14.8 0.2 0.023 14.8 0.2 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.6 CCF54863.1 - 0.028 15.1 4.9 0.22 12.2 0.0 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.6 CCF54863.1 - 0.048 13.9 0.1 0.048 13.9 0.1 3.1 3 1 1 4 4 4 0 Tetratricopeptide repeat ANAPC3 PF12895.7 CCF54863.1 - 0.052 13.8 5.0 0.34 11.2 3.3 2.8 2 1 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_1 PF00515.28 CCF54863.1 - 0.43 10.5 4.1 0.16 11.9 0.3 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_19 PF14559.6 CCF54863.1 - 3 8.4 9.8 3.4 8.2 2.1 3.4 3 1 0 3 3 3 0 Tetratricopeptide repeat CBFD_NFYB_HMF PF00808.23 CCF54864.1 - 3.3e-14 52.9 0.7 5e-14 52.3 0.7 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 CCF54864.1 - 6.6e-05 23.3 0.1 0.00012 22.5 0.1 1.4 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Ribosomal_60s PF00428.19 CCF54864.1 - 0.031 14.9 1.0 0.063 13.9 1.0 1.5 1 1 0 1 1 1 0 60s Acidic ribosomal protein Ras PF00071.22 CCF54865.1 - 6.5e-57 191.6 0.2 8.6e-57 191.3 0.2 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CCF54865.1 - 3.2e-34 117.7 0.0 4.7e-34 117.2 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CCF54865.1 - 1.8e-15 56.9 0.0 5.1e-15 55.3 0.0 1.7 1 1 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 CCF54865.1 - 1.2e-05 24.8 0.0 1.4e-05 24.5 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 CCF54865.1 - 0.00026 21.1 0.0 0.00042 20.4 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.6 CCF54865.1 - 0.0012 19.2 0.3 0.0021 18.5 0.3 1.5 1 1 0 1 1 1 1 AAA ATPase domain GTP_EFTU PF00009.27 CCF54865.1 - 0.0019 17.8 0.0 0.0023 17.5 0.0 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 CCF54865.1 - 0.028 14.3 0.1 6.4 6.7 0.0 2.7 2 1 1 3 3 3 0 RsgA GTPase HSP70 PF00012.20 CCF54866.1 - 2.3e-58 197.9 2.8 6.5e-55 186.5 0.0 3.9 3 2 0 3 3 3 2 Hsp70 protein Metallophos PF00149.28 CCF54867.1 - 2.5e-34 119.6 0.1 5.1e-34 118.6 0.1 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 CCF54867.1 - 0.056 13.9 0.0 0.14 12.7 0.0 1.6 1 0 0 1 1 1 0 Serine-threonine protein phosphatase N-terminal domain Herpes_LMP2 PF07415.11 CCF54868.1 - 3.6 6.2 3.5 4.5 5.9 3.5 1.2 1 0 0 1 1 1 0 Gammaherpesvirus latent membrane protein (LMP2) protein UCH PF00443.29 CCF54871.1 - 2.5e-42 145.1 0.0 7.5e-42 143.6 0.0 1.8 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 CCF54871.1 - 3.4e-17 63.0 0.0 1.4e-11 44.6 0.0 2.3 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 CCF54871.1 - 3.9e-13 49.5 3.0 3.9e-13 49.5 3.0 2.8 3 0 0 3 3 3 1 Zn-finger in ubiquitin-hydrolases and other protein TF_Zn_Ribbon PF08271.12 CCF54871.1 - 1.4 8.5 6.8 8.7 6.0 2.3 2.9 2 0 0 2 2 2 0 TFIIB zinc-binding Abhydrolase_3 PF07859.13 CCF54872.1 - 5.9e-17 62.2 0.0 7.6e-15 55.3 0.0 2.5 2 0 0 2 2 2 2 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 CCF54872.1 - 3.6e-11 42.6 0.0 2e-10 40.1 0.0 1.9 2 0 0 2 2 2 1 Steryl acetyl hydrolase Methyltransf_15 PF09445.10 CCF54873.1 - 6.3e-33 113.7 0.0 1.1e-25 90.1 0.0 2.2 2 0 0 2 2 2 2 RNA cap guanine-N2 methyltransferase Met_10 PF02475.16 CCF54873.1 - 0.00019 21.3 0.0 0.00028 20.7 0.0 1.2 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_25 PF13649.6 CCF54873.1 - 0.001 19.7 0.0 0.0039 17.9 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF54873.1 - 0.012 15.4 0.0 0.021 14.6 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Cons_hypoth95 PF03602.15 CCF54873.1 - 0.015 14.9 0.0 0.12 12.0 0.0 2.0 2 0 0 2 2 2 0 Conserved hypothetical protein 95 tRNA_U5-meth_tr PF05958.11 CCF54873.1 - 0.035 13.1 0.0 0.059 12.4 0.0 1.3 1 0 0 1 1 1 0 tRNA (Uracil-5-)-methyltransferase Methyltransf_3 PF01596.17 CCF54873.1 - 0.056 12.6 0.0 0.087 12.0 0.0 1.2 1 0 0 1 1 1 0 O-methyltransferase UPF0020 PF01170.18 CCF54873.1 - 0.18 11.5 0.0 0.34 10.6 0.0 1.4 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 PrmA PF06325.13 CCF54873.1 - 0.21 11.0 0.0 0.34 10.3 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) RVT_2 PF07727.14 CCF54874.1 - 6e-44 150.5 1.1 1.7e-32 113.0 0.1 2.3 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) gag_pre-integrs PF13976.6 CCF54874.1 - 1.1e-05 25.2 0.0 3.4e-05 23.6 0.0 1.9 1 0 0 1 1 1 1 GAG-pre-integrase domain Mo25 PF08569.11 CCF54875.1 - 3.1e-136 454.0 1.4 4e-136 453.7 1.4 1.1 1 0 0 1 1 1 1 Mo25-like DUF2183 PF09949.9 CCF54875.1 - 0.016 15.5 0.0 0.057 13.8 0.0 1.9 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2183) HEAT_2 PF13646.6 CCF54875.1 - 0.13 12.7 0.0 1.7 9.1 0.0 2.7 3 0 0 3 3 3 0 HEAT repeats ARID PF01388.21 CCF54876.1 - 1.4e-11 44.9 0.7 4.5e-10 40.1 0.0 3.4 4 0 0 4 4 4 1 ARID/BRIGHT DNA binding domain BAF250_C PF12031.8 CCF54876.1 - 9.6e-08 31.6 9.0 1.4e-07 31.1 0.2 3.4 2 1 0 2 2 2 1 SWI/SNF-like complex subunit BAF250/Osa Peptidase_M41 PF01434.18 CCF54877.1 - 8.7e-64 214.9 0.0 1.4e-63 214.3 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 CCF54877.1 - 1.3e-42 145.4 0.0 2.8e-42 144.2 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) FtsH_ext PF06480.15 CCF54877.1 - 2.6e-13 50.3 0.1 5.9e-13 49.1 0.1 1.6 1 0 0 1 1 1 1 FtsH Extracellular AAA_lid_3 PF17862.1 CCF54877.1 - 1.1e-12 47.6 0.1 2.5e-12 46.4 0.1 1.6 1 0 0 1 1 1 1 AAA+ lid domain TIP49 PF06068.13 CCF54877.1 - 0.0015 17.9 0.1 0.0024 17.1 0.1 1.3 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_16 PF13191.6 CCF54877.1 - 0.0027 18.1 0.1 0.16 12.4 0.1 3.0 3 0 0 3 3 3 1 AAA ATPase domain AAA_22 PF13401.6 CCF54877.1 - 0.0038 17.5 0.1 0.82 9.9 0.1 2.8 1 1 0 2 2 2 1 AAA domain RuvB_N PF05496.12 CCF54877.1 - 0.0073 16.1 0.0 0.016 14.9 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 CCF54877.1 - 0.013 15.5 0.0 0.059 13.4 0.0 2.3 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 CCF54877.1 - 0.033 14.3 0.7 0.15 12.2 0.0 2.4 2 1 0 2 2 2 0 AAA domain (Cdc48 subfamily) AAA_17 PF13207.6 CCF54877.1 - 0.044 14.2 0.7 0.11 12.9 0.0 2.1 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 CCF54877.1 - 0.095 12.4 0.0 0.2 11.4 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein Rgp1 PF08737.10 CCF54877.1 - 1.1 8.4 4.3 1.9 7.6 4.3 1.3 1 0 0 1 1 1 0 Rgp1 Drf_GBD PF06371.13 CCF54878.1 - 2e-08 34.0 0.0 7.3e-05 22.4 0.0 2.3 2 0 0 2 2 2 2 Diaphanous GTPase-binding Domain Rcd1 PF04078.13 CCF54878.1 - 0.092 12.0 0.0 0.15 11.4 0.0 1.3 1 0 0 1 1 1 0 Cell differentiation family, Rcd1-like Kinesin PF00225.23 CCF54879.1 - 6.9e-112 373.7 0.1 6.9e-112 373.7 0.1 2.3 2 1 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 CCF54879.1 - 5.6e-27 94.5 0.0 1.6e-26 93.0 0.0 1.9 1 0 0 1 1 1 1 Microtubule binding DUF3450 PF11932.8 CCF54879.1 - 0.0095 15.3 1.4 0.0095 15.3 1.4 6.2 3 1 3 6 6 6 1 Protein of unknown function (DUF3450) Secretin_N PF03958.17 CCF54879.1 - 0.13 12.7 0.0 0.13 12.7 0.0 3.9 3 1 0 3 3 3 0 Bacterial type II/III secretion system short domain GATA PF00320.27 CCF54880.1 - 3.6e-12 45.7 5.3 7.7e-12 44.6 5.3 1.6 1 0 0 1 1 1 1 GATA zinc finger PAS_4 PF08448.10 CCF54880.1 - 0.0039 17.4 2.7 0.066 13.5 0.1 2.9 3 0 0 3 3 3 1 PAS fold PAS_3 PF08447.12 CCF54880.1 - 0.013 15.8 0.0 0.039 14.2 0.0 1.8 1 0 0 1 1 1 0 PAS fold GCD14 PF08704.10 CCF54881.1 - 2.1e-82 276.5 7.1 1.8e-47 162.1 4.4 3.4 2 1 0 2 2 2 2 tRNA methyltransferase complex GCD14 subunit Efg1 PF10153.9 CCF54881.1 - 0.65 10.4 5.0 0.24 11.8 1.8 2.0 2 1 0 2 2 2 0 rRNA-processing protein Efg1 Velvet PF11754.8 CCF54883.1 - 1.2e-49 169.6 0.0 2.6e-33 116.0 0.1 3.7 2 2 1 3 3 3 2 Velvet factor LSM PF01423.22 CCF54885.1 - 1.2e-19 69.7 0.4 1.4e-19 69.5 0.4 1.0 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 CCF54885.1 - 1.3e-05 25.2 0.1 1.7e-05 24.8 0.1 1.3 1 1 0 1 1 1 1 Ataxin 2 SM domain LSM14 PF12701.7 CCF54885.1 - 0.0021 18.1 0.2 0.0025 17.9 0.2 1.2 1 0 0 1 1 1 1 Scd6-like Sm domain PET117 PF15786.5 CCF54886.1 - 1.6e-20 73.1 1.0 1.6e-20 73.1 1.0 2.2 2 0 0 2 2 2 1 PET assembly of cytochrome c oxidase, mitochondrial MAGUK_N_PEST PF10608.9 CCF54886.1 - 0.029 14.8 0.0 0.067 13.6 0.0 1.8 1 1 0 1 1 1 0 Polyubiquitination (PEST) N-terminal domain of MAGUK DHHA2 PF02833.14 CCF54887.1 - 5.6e-34 117.4 0.3 1e-33 116.6 0.3 1.4 1 0 0 1 1 1 1 DHHA2 domain DHH PF01368.20 CCF54887.1 - 2.2e-10 40.7 0.0 3.9e-10 39.9 0.0 1.4 1 0 0 1 1 1 1 DHH family Glyco_hydro_48 PF02011.15 CCF54887.1 - 0.035 12.7 0.0 0.16 10.5 0.0 1.8 1 1 1 2 2 2 0 Glycosyl hydrolase family 48 WD40 PF00400.32 CCF54888.1 - 0.0053 17.6 0.8 0.045 14.6 0.0 2.6 3 1 0 3 3 3 1 WD domain, G-beta repeat UCR_hinge PF02320.16 CCF54889.1 - 8.6e-25 86.7 6.4 1.7e-24 85.8 6.4 1.4 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase hinge protein DUF4611 PF15387.6 CCF54889.1 - 0.029 14.6 4.3 0.041 14.1 4.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) CENP-B_dimeris PF09026.10 CCF54889.1 - 0.065 13.6 10.7 0.11 12.9 10.7 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DNA_pol_phi PF04931.13 CCF54889.1 - 0.26 9.4 7.5 0.28 9.2 7.5 1.1 1 0 0 1 1 1 0 DNA polymerase phi FAM176 PF14851.6 CCF54889.1 - 0.44 10.2 6.2 0.55 9.9 6.2 1.2 1 0 0 1 1 1 0 FAM176 family CENP-T_N PF16171.5 CCF54889.1 - 0.56 9.1 3.3 0.62 8.9 3.3 1.1 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T N-terminus CDC45 PF02724.14 CCF54889.1 - 1.1 7.5 5.0 1.1 7.4 5.0 1.0 1 0 0 1 1 1 0 CDC45-like protein Astro_capsid_p PF12226.8 CCF54889.1 - 8.7 5.4 8.8 10 5.1 8.8 1.1 1 0 0 1 1 1 0 Turkey astrovirus capsid protein DUF3384 PF11864.8 CCF54890.1 - 3.3e-169 563.8 7.2 5e-158 526.9 1.3 3.2 3 0 0 3 3 3 3 Domain of unknown function (DUF3384) Rap_GAP PF02145.15 CCF54890.1 - 9.7e-47 158.9 0.0 1.8e-46 158.0 0.0 1.5 1 0 0 1 1 1 1 Rap/ran-GAP Tuberin PF03542.16 CCF54890.1 - 1.8e-37 129.3 9.5 3.1e-32 112.1 9.0 3.3 2 1 0 2 2 2 2 Tuberin FMN_dh PF01070.18 CCF54891.1 - 4.6e-120 400.8 0.6 5.4e-120 400.6 0.6 1.0 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Cyt-b5 PF00173.28 CCF54891.1 - 1e-20 73.7 0.0 2.2e-20 72.6 0.0 1.6 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain IMPDH PF00478.25 CCF54891.1 - 6.2e-05 22.2 0.1 0.0001 21.5 0.1 1.4 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain Glu_synthase PF01645.17 CCF54891.1 - 8.3e-05 21.9 0.0 0.00015 21.0 0.0 1.3 1 0 0 1 1 1 1 Conserved region in glutamate synthase NMO PF03060.15 CCF54891.1 - 0.0016 17.9 0.3 0.003 17.0 0.3 1.4 1 0 0 1 1 1 1 Nitronate monooxygenase ThiG PF05690.14 CCF54891.1 - 0.042 13.1 0.0 1.5 8.1 0.0 2.4 2 0 0 2 2 2 0 Thiazole biosynthesis protein ThiG His_biosynth PF00977.21 CCF54891.1 - 0.084 12.3 0.1 0.18 11.2 0.1 1.6 1 1 0 1 1 1 0 Histidine biosynthesis protein Aminotran_1_2 PF00155.21 CCF54892.1 - 1.7e-49 168.9 0.0 1.9e-46 158.9 0.0 2.6 2 1 0 2 2 2 2 Aminotransferase class I and II OKR_DC_1 PF01276.20 CCF54892.1 - 0.0075 15.0 0.0 0.013 14.2 0.0 1.3 1 0 0 1 1 1 1 Orn/Lys/Arg decarboxylase, major domain Beta_elim_lyase PF01212.21 CCF54892.1 - 0.1 11.8 0.0 0.16 11.2 0.0 1.3 1 0 0 1 1 1 0 Beta-eliminating lyase Ribosomal_L24e PF01246.20 CCF54893.1 - 2.5e-31 107.7 0.4 2.5e-31 107.7 0.4 1.8 2 0 0 2 2 2 1 Ribosomal protein L24e HLH PF00010.26 CCF54894.1 - 6.2e-10 38.9 0.2 1.3e-09 37.9 0.2 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain SUIM_assoc PF16619.5 CCF54894.1 - 4.1e-06 26.8 6.6 0.00085 19.3 6.0 3.6 1 1 0 1 1 1 1 Unstructured region C-term to UIM in Ataxin3 Activator_LAG-3 PF11498.8 CCF54894.1 - 0.031 13.2 30.8 0.078 11.9 30.8 1.7 1 0 0 1 1 1 0 Transcriptional activator LAG-3 TMEM247 PF15444.6 CCF54894.1 - 0.12 12.4 6.3 0.23 11.5 6.3 1.4 1 0 0 1 1 1 0 Transmembrane protein 247 TMEM51 PF15345.6 CCF54894.1 - 0.28 11.0 6.8 0.65 9.8 4.2 2.4 2 0 0 2 2 2 0 Transmembrane protein 51 SOGA PF11365.8 CCF54894.1 - 0.3 12.2 9.7 5 8.3 0.1 2.5 2 0 0 2 2 2 0 Protein SOGA UPF0560 PF10577.9 CCF54894.1 - 0.9 8.0 18.0 0.65 8.4 16.5 1.4 2 0 0 2 2 2 0 Uncharacterised protein family UPF0560 Serinc PF03348.15 CCF54894.1 - 1.5 7.7 4.2 2 7.2 4.2 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) LMBR1 PF04791.16 CCF54894.1 - 4.4 6.1 4.6 6.6 5.5 4.6 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF1387 PF07139.11 CCF54894.1 - 6.6 6.4 12.8 0.34 10.6 7.3 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1387) NAT PF04768.13 CCF54895.1 - 1e-48 165.2 0.1 2.1e-48 164.2 0.1 1.5 1 0 0 1 1 1 1 NAT, N-acetyltransferase, of N-acetylglutamate synthase AA_kinase PF00696.28 CCF54895.1 - 1.4e-27 96.8 0.0 2.7e-27 95.9 0.0 1.5 1 0 0 1 1 1 1 Amino acid kinase family Semialdhyde_dh PF01118.24 CCF54895.1 - 6e-27 94.5 0.0 1.6e-26 93.1 0.0 1.8 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain DapB_N PF01113.20 CCF54895.1 - 0.07 13.2 0.0 0.16 12.1 0.0 1.6 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus Pam16 PF03656.13 CCF54895.1 - 0.52 10.3 0.0 0.52 10.3 0.0 2.2 2 0 0 2 2 2 0 Pam16 zf-C2H2 PF00096.26 CCF54896.1 - 4.5e-10 39.4 14.8 8.5e-06 26.0 3.9 3.5 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 CCF54896.1 - 4e-05 23.8 14.5 4.5e-05 23.7 2.5 3.5 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 CCF54896.1 - 5.3e-05 23.7 13.9 0.044 14.6 1.3 3.4 3 0 0 3 3 3 2 C2H2-type zinc finger FOXP-CC PF16159.5 CCF54896.1 - 0.0017 19.0 3.7 0.058 14.0 0.5 2.4 1 1 1 2 2 2 1 FOXP coiled-coil domain ARS2 PF04959.13 CCF54896.1 - 0.28 11.5 1.2 6.8 7.0 0.6 2.5 2 0 0 2 2 2 0 Arsenite-resistance protein 2 zf-C2H2_aberr PF17017.5 CCF54896.1 - 0.3 11.2 6.1 2.9 8.0 2.2 2.2 1 1 1 2 2 2 0 Aberrant zinc-finger zf-met PF12874.7 CCF54896.1 - 0.59 10.6 2.7 5.1 7.6 0.4 2.7 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-H2C2_5 PF13909.6 CCF54896.1 - 8.9 6.2 9.3 8 6.3 1.9 2.6 2 0 0 2 2 2 0 C2H2-type zinc-finger domain CRIM PF16978.5 CCF54897.1 - 3.2e-42 144.0 0.0 8.6e-42 142.6 0.0 1.8 1 0 0 1 1 1 1 SAPK-interacting protein 1 (Sin1), middle CRIM domain SIN1_PH PF16979.5 CCF54897.1 - 7.8e-25 87.3 0.0 1.3e-24 86.6 0.0 1.4 1 0 0 1 1 1 1 SAPK-interacting protein 1 (Sin1), Pleckstrin-homology TUG-UBL1 PF11470.8 CCF54897.1 - 0.014 15.6 0.0 0.033 14.4 0.0 1.5 1 0 0 1 1 1 0 TUG ubiquitin-like domain RA PF00788.23 CCF54897.1 - 0.14 12.8 0.0 1.5 9.5 0.0 2.2 2 0 0 2 2 2 0 Ras association (RalGDS/AF-6) domain SANT_DAMP1_like PF16282.5 CCF54898.1 - 3e-31 107.4 3.0 5.2e-31 106.7 3.0 1.4 1 0 0 1 1 1 1 SANT/Myb-like domain of DAMP1 DMAP1 PF05499.12 CCF54898.1 - 0.0086 16.0 0.0 1.8 8.4 0.0 2.7 2 0 0 2 2 2 2 DNA methyltransferase 1-associated protein 1 (DMAP1) Myb_DNA-bind_6 PF13921.6 CCF54898.1 - 0.014 15.6 0.0 0.041 14.1 0.0 1.8 1 0 0 1 1 1 0 Myb-like DNA-binding domain RasGAP PF00616.19 CCF54899.1 - 7.3e-60 202.2 0.0 2e-59 200.8 0.0 1.8 1 0 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase RasGAP_C PF03836.15 CCF54899.1 - 6.3e-40 136.5 0.2 6.3e-40 136.5 0.2 2.2 3 0 0 3 3 3 1 RasGAP C-terminus YabA PF06156.13 CCF54899.1 - 0.011 16.3 1.0 4.1 8.1 0.0 3.3 2 0 0 2 2 2 0 Initiation control protein YabA Cyclase_polyket PF04673.12 CCF54899.1 - 0.1 12.9 0.0 0.34 11.2 0.0 1.9 1 0 0 1 1 1 0 Polyketide synthesis cyclase BLOC1_2 PF10046.9 CCF54899.1 - 7 7.0 9.5 6.5 7.1 0.7 3.8 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 RVT_2 PF07727.14 CCF54900.1 - 1.3e-43 149.4 0.9 3.9e-37 128.2 0.1 2.2 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) GCP_N_terminal PF17681.1 CCF54902.1 - 6e-88 295.4 0.0 1.9e-87 293.8 0.0 1.8 2 0 0 2 2 2 1 Gamma tubulin complex component N-terminal GCP_C_terminal PF04130.13 CCF54902.1 - 1.1e-75 255.0 0.0 2e-75 254.1 0.0 1.5 1 0 0 1 1 1 1 Gamma tubulin complex component C-terminal AMP-binding PF00501.28 CCF54904.1 - 2e-10 39.9 0.1 2e-10 39.9 0.1 1.1 1 0 0 1 1 1 1 AMP-binding enzyme Kin17_mid PF10357.9 CCF54905.1 - 3.4e-49 166.0 0.9 7.4e-49 164.9 0.9 1.6 1 0 0 1 1 1 1 Domain of Kin17 curved DNA-binding protein zf-met PF12874.7 CCF54905.1 - 1.1e-05 25.7 1.5 2.2e-05 24.7 1.5 1.6 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 CCF54905.1 - 1.2e-05 25.4 1.9 2.4e-05 24.5 1.9 1.5 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 CCF54905.1 - 0.0028 17.9 1.6 0.0087 16.4 0.1 2.2 2 0 0 2 2 2 1 C2H2 type zinc-finger (2 copies) AKAP95 PF04988.12 CCF54905.1 - 0.0055 16.9 0.6 0.0055 16.9 0.6 2.3 3 0 0 3 3 3 1 A-kinase anchoring protein 95 (AKAP95) DUF2470 PF10615.9 CCF54905.1 - 0.038 14.6 0.2 0.093 13.4 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2470) zf-C2H2_4 PF13894.6 CCF54905.1 - 0.31 12.0 1.8 0.53 11.3 0.6 2.0 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2 PF00096.26 CCF54905.1 - 0.35 11.4 1.5 0.76 10.4 0.9 1.9 2 0 0 2 2 2 0 Zinc finger, C2H2 type Pkinase PF00069.25 CCF54906.1 - 2.7e-49 167.9 0.0 6.1e-47 160.2 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CCF54906.1 - 1.7e-20 73.4 0.0 1.2e-16 60.8 0.0 3.1 3 0 0 3 3 3 3 Protein tyrosine kinase Pkinase_fungal PF17667.1 CCF54906.1 - 0.0024 16.7 0.0 0.0058 15.5 0.0 1.5 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 CCF54906.1 - 0.0053 16.7 2.3 0.029 14.3 0.3 2.8 3 1 0 3 3 3 1 Phosphotransferase enzyme family Kdo PF06293.14 CCF54906.1 - 0.028 13.8 0.0 0.047 13.0 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 CCF54906.1 - 0.077 12.3 0.0 0.18 11.1 0.0 1.5 1 1 0 1 1 1 0 Kinase-like Haspin_kinase PF12330.8 CCF54906.1 - 0.23 10.3 0.0 0.23 10.3 0.0 2.4 3 0 0 3 3 3 0 Haspin like kinase domain RGS PF00615.19 CCF54907.1 - 5.5e-12 46.0 0.1 2.4e-06 27.8 0.0 2.5 2 1 0 2 2 2 2 Regulator of G protein signaling domain FA_desaturase PF00487.24 CCF54908.1 - 8.1e-15 55.3 27.8 8.1e-15 55.3 27.8 1.5 1 1 0 1 1 1 1 Fatty acid desaturase Cyt-b5 PF00173.28 CCF54908.1 - 1.7e-13 50.5 0.1 3.6e-13 49.4 0.1 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain DHHA2 PF02833.14 CCF54909.1 - 4.2e-17 62.7 0.2 7.8e-17 61.8 0.1 1.5 2 0 0 2 2 2 1 DHHA2 domain DHH PF01368.20 CCF54909.1 - 2.7e-08 34.0 0.0 5.3e-08 33.0 0.0 1.5 1 0 0 1 1 1 1 DHH family UBA_4 PF14555.6 CCF54909.1 - 0.093 12.6 0.3 0.33 10.8 0.2 2.0 2 0 0 2 2 2 0 UBA-like domain Ribonuc_2-5A PF06479.12 CCF54909.1 - 0.1 12.8 2.0 9.3 6.4 0.1 2.4 2 0 0 2 2 2 0 Ribonuclease 2-5A SNARE_assoc PF09335.11 CCF54910.1 - 1e-31 109.9 5.0 3.3e-31 108.3 5.1 1.9 2 0 0 2 2 2 1 SNARE associated Golgi protein SHMT PF00464.19 CCF54912.1 - 8e-175 581.2 0.0 9.3e-175 581.0 0.0 1.0 1 0 0 1 1 1 1 Serine hydroxymethyltransferase Beta_elim_lyase PF01212.21 CCF54912.1 - 0.0034 16.7 0.0 0.007 15.7 0.0 1.6 1 1 0 1 1 1 1 Beta-eliminating lyase DUF4142 PF13628.6 CCF54912.1 - 0.058 13.6 0.1 0.18 12.1 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4142) NTP_transf_9 PF04248.12 CCF54913.1 - 9.1e-31 105.6 0.8 3.4e-30 103.8 0.0 2.4 3 0 0 3 3 3 1 Domain of unknown function (DUF427) DCP2 PF05026.13 CCF54913.1 - 1.1e-24 86.5 0.0 1.8e-24 85.9 0.0 1.3 1 0 0 1 1 1 1 Dcp2, box A domain NUDIX PF00293.28 CCF54913.1 - 5.6e-14 52.3 0.0 1.3e-13 51.1 0.0 1.6 1 0 0 1 1 1 1 NUDIX domain Cys_Met_Meta_PP PF01053.20 CCF54915.1 - 1.6e-138 461.4 0.0 3.7e-138 460.2 0.0 1.5 1 1 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 CCF54915.1 - 0.029 13.7 0.0 0.074 12.3 0.0 1.6 2 0 0 2 2 2 0 DegT/DnrJ/EryC1/StrS aminotransferase family ADK PF00406.22 CCF54916.1 - 2.1e-06 27.9 0.0 0.00075 19.6 0.0 2.4 2 0 0 2 2 2 2 Adenylate kinase V-SNARE PF05008.15 CCF54916.1 - 0.014 15.7 0.2 0.26 11.7 0.0 2.8 2 1 1 3 3 3 0 Vesicle transport v-SNARE protein N-terminus AAA_17 PF13207.6 CCF54916.1 - 0.033 14.6 0.5 3.3 8.2 0.0 3.0 2 1 1 3 3 3 0 AAA domain AAA_33 PF13671.6 CCF54916.1 - 0.035 14.3 0.0 0.096 12.9 0.0 1.8 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 CCF54916.1 - 0.037 14.6 0.1 0.1 13.1 0.0 1.7 2 0 0 2 2 2 0 ABC transporter AAA_22 PF13401.6 CCF54916.1 - 0.057 13.7 0.0 0.21 11.8 0.0 1.9 1 1 0 1 1 1 0 AAA domain ApoA-II PF04711.13 CCF54916.1 - 0.14 12.3 1.5 0.39 10.9 0.1 2.3 3 0 0 3 3 3 0 Apolipoprotein A-II (ApoA-II) Guanylate_kin PF00625.21 CCF54916.1 - 1.7 8.3 5.3 2.2 8.0 0.0 3.1 2 1 0 3 3 3 0 Guanylate kinase SIR2 PF02146.17 CCF54917.1 - 2.3e-56 190.5 0.0 3.9e-56 189.8 0.0 1.4 1 0 0 1 1 1 1 Sir2 family DUF592 PF04574.13 CCF54917.1 - 8e-09 35.4 0.8 1e-05 25.3 0.3 2.6 1 1 1 2 2 2 2 Protein of unknown function (DUF592) TPP_enzyme_M PF00205.22 CCF54917.1 - 0.018 14.8 0.0 3.8 7.3 0.0 2.3 2 0 0 2 2 2 0 Thiamine pyrophosphate enzyme, central domain CutC PF03932.14 CCF54917.1 - 0.023 14.1 0.0 0.048 13.1 0.0 1.5 1 0 0 1 1 1 0 CutC family Ogr_Delta PF04606.12 CCF54917.1 - 3.3 7.8 5.1 0.42 10.6 0.6 1.8 2 0 0 2 2 2 0 Ogr/Delta-like zinc finger NGP1NT PF08153.12 CCF54918.1 - 4.3e-47 159.5 0.0 1.3e-46 157.9 0.0 1.8 2 0 0 2 2 2 1 NGP1NT (NUC091) domain MMR_HSR1 PF01926.23 CCF54918.1 - 2e-16 60.1 0.0 1.1e-13 51.3 0.0 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase FeoB_N PF02421.18 CCF54918.1 - 1e-05 25.1 0.2 3.8e-05 23.3 0.1 1.9 2 0 0 2 2 2 1 Ferrous iron transport protein B Arf PF00025.21 CCF54918.1 - 0.0002 20.8 0.1 0.069 12.6 0.0 2.3 2 0 0 2 2 2 2 ADP-ribosylation factor family RsgA_GTPase PF03193.16 CCF54918.1 - 0.0028 17.6 0.0 0.012 15.5 0.0 2.1 2 0 0 2 2 2 1 RsgA GTPase Dynamin_N PF00350.23 CCF54918.1 - 0.27 11.3 6.4 0.94 9.5 0.0 3.7 4 1 1 5 5 5 0 Dynamin family zf_CCCH_4 PF18345.1 CCF54919.1 - 1.3e-08 34.6 13.6 3.6e-06 26.9 7.5 2.8 2 0 0 2 2 2 2 Zinc finger domain zf-CCCH PF00642.24 CCF54919.1 - 3.3e-08 33.2 10.9 4.2e-07 29.7 4.6 2.9 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-C3HC4 PF00097.25 CCF54919.1 - 2.1e-06 27.5 11.7 2.1e-06 27.5 11.7 2.2 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-CCCH_4 PF18044.1 CCF54919.1 - 3.5e-06 26.7 12.0 2e-05 24.2 5.5 2.8 2 0 0 2 2 2 1 CCCH-type zinc finger zf-C3HC4_3 PF13920.6 CCF54919.1 - 4.9e-06 26.3 9.1 1.1e-05 25.2 9.1 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CCF54919.1 - 1.3e-05 25.4 12.0 1.3e-05 25.4 12.0 2.5 3 1 0 3 3 2 1 Ring finger domain Torus PF16131.5 CCF54919.1 - 0.0002 22.0 1.5 0.053 14.2 0.1 2.5 2 0 0 2 2 2 1 Torus domain zf-RING_5 PF14634.6 CCF54919.1 - 0.001 19.0 10.5 0.001 19.0 10.5 1.9 2 0 0 2 2 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 CCF54919.1 - 0.0034 17.2 12.8 0.005 16.7 11.2 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 CCF54919.1 - 0.018 15.2 8.8 0.052 13.7 8.8 1.9 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.6 CCF54919.1 - 0.027 14.5 10.8 0.027 14.5 10.8 2.4 2 0 0 2 2 2 0 RING-type zinc-finger zf-CCCH_2 PF14608.6 CCF54919.1 - 0.029 14.8 3.8 0.029 14.8 3.8 3.8 4 0 0 4 4 4 0 RNA-binding, Nab2-type zinc finger zf-CCCH_3 PF15663.5 CCF54919.1 - 0.051 13.8 0.6 0.051 13.8 0.6 2.3 3 0 0 3 3 2 0 Zinc-finger containing family PAM2 PF07145.15 CCF54919.1 - 0.1 12.3 0.4 13 5.8 0.0 2.7 1 1 1 2 2 2 0 Ataxin-2 C-terminal region Prok-RING_4 PF14447.6 CCF54919.1 - 0.16 11.8 9.4 0.48 10.3 9.4 1.8 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-rbx1 PF12678.7 CCF54919.1 - 0.19 12.0 13.4 0.64 10.4 13.4 1.9 1 1 0 1 1 1 0 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 CCF54919.1 - 0.39 10.8 6.5 2 8.5 6.7 2.0 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_4 PF14570.6 CCF54919.1 - 0.44 10.4 8.2 1.1 9.1 8.2 1.7 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain FANCL_C PF11793.8 CCF54919.1 - 1.4 9.2 9.8 4.3 7.6 9.8 1.8 1 1 0 1 1 1 0 FANCL C-terminal domain RPE65 PF03055.15 CCF54920.1 - 9.7e-119 397.6 0.0 1.2e-118 397.3 0.0 1.0 1 0 0 1 1 1 1 Retinal pigment epithelial membrane protein SNF2_N PF00176.23 CCF54921.1 - 2.9e-43 148.0 0.0 4.2e-43 147.4 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 CCF54921.1 - 2.9e-21 75.9 0.0 6.4e-20 71.6 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain VIGSSK PF14773.6 CCF54921.1 - 2e-15 56.6 1.3 5.4e-15 55.3 1.3 1.8 1 0 0 1 1 1 1 Helicase-associated putative binding domain, C-terminal ResIII PF04851.15 CCF54921.1 - 3.3e-05 23.9 0.0 7.2e-05 22.9 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 CCF54921.1 - 0.00022 20.5 0.0 0.0004 19.7 0.0 1.3 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase SPX PF03105.19 CCF54923.1 - 1 9.2 5.0 1 9.2 5.0 1.1 1 0 0 1 1 1 0 SPX domain Hid1 PF12722.7 CCF54923.1 - 2.3 6.2 3.1 2.8 6.0 3.1 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein SOG2 PF10428.9 CCF54923.1 - 7.3 5.7 17.7 8.3 5.5 17.7 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein Elf1 PF05129.13 CCF54924.1 - 1e-28 99.2 0.7 1.2e-28 99.0 0.7 1.0 1 0 0 1 1 1 1 Transcription elongation factor Elf1 like zf-Sec23_Sec24 PF04810.15 CCF54924.1 - 0.21 11.6 3.5 8.7 6.5 0.7 2.3 1 1 1 2 2 2 0 Sec23/Sec24 zinc finger Zn-ribbon_8 PF09723.10 CCF54924.1 - 0.34 11.1 2.9 1.1 9.5 3.0 1.8 1 1 1 2 2 2 0 Zinc ribbon domain Ank_4 PF13637.6 CCF54925.1 - 5e-14 52.5 0.2 1e-05 26.0 0.0 2.7 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 CCF54925.1 - 1.1e-11 45.2 0.1 2.3e-09 37.7 0.0 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 CCF54925.1 - 2.9e-10 40.2 0.2 1.4e-07 31.7 0.0 2.4 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 CCF54925.1 - 2.4e-07 30.5 0.0 0.0002 21.5 0.1 3.9 4 0 0 4 4 4 1 Ankyrin repeat Ank PF00023.30 CCF54925.1 - 1.9e-06 28.1 0.3 1.1e-05 25.6 0.5 2.2 3 0 0 3 3 3 1 Ankyrin repeat YwqJ-deaminase PF14431.6 CCF54925.1 - 0.07 13.3 0.3 0.14 12.4 0.0 1.6 2 0 0 2 2 2 0 YwqJ-like deaminase I_LWEQ PF01608.17 CCF54925.1 - 1.6 8.9 8.9 2 8.6 7.5 1.8 1 1 1 2 2 2 0 I/LWEQ domain HSP70 PF00012.20 CCF54927.1 - 3.6e-257 854.4 10.8 4.1e-257 854.2 10.8 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 CCF54927.1 - 3e-19 69.0 1.1 1.6e-18 66.6 0.4 2.0 2 0 0 2 2 2 1 MreB/Mbl protein Hydantoinase_A PF01968.18 CCF54927.1 - 0.0046 16.2 4.5 0.07 12.4 0.1 3.1 3 0 0 3 3 3 1 Hydantoinase/oxoprolinase DUF4624 PF15417.6 CCF54927.1 - 0.031 14.1 0.0 2 8.2 0.1 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4624) TRAF_BIRC3_bd PF16673.5 CCF54927.1 - 0.063 13.1 3.5 0.45 10.3 1.1 2.9 3 0 0 3 3 3 0 TNF receptor-associated factor BIRC3 binding domain HOIP-UBA PF16678.5 CCF54927.1 - 0.076 13.0 1.1 0.27 11.2 0.0 2.2 2 0 0 2 2 2 0 HOIP UBA domain pair Com_YlbF PF06133.11 CCF54927.1 - 0.085 13.5 4.0 0.25 12.0 4.0 1.8 1 0 0 1 1 1 0 Control of competence regulator ComK, YlbF/YmcA DUF2680 PF10925.8 CCF54927.1 - 0.89 9.6 4.3 1.8 8.6 0.1 3.3 3 1 1 4 4 4 0 Protein of unknown function (DUF2680) UPF0242 PF06785.11 CCF54927.1 - 0.92 9.6 5.2 1.7 8.7 5.2 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Latarcin PF10279.9 CCF54927.1 - 3.1 8.3 6.5 50 4.4 3.9 2.8 2 0 0 2 2 2 0 Latarcin precursor Seryl_tRNA_N PF02403.22 CCF54927.1 - 7.8 6.8 15.3 5.3 7.3 5.1 3.9 3 1 1 4 4 4 0 Seryl-tRNA synthetase N-terminal domain zf-U1 PF06220.12 CCF54928.1 - 7.5e-08 32.0 1.2 1.3e-07 31.2 1.2 1.4 1 0 0 1 1 1 1 U1 zinc finger GSIII_N PF12437.8 CCF54928.1 - 0.64 9.7 5.5 0.53 9.9 0.3 2.8 2 1 1 3 3 3 0 Glutamine synthetase type III N terminal IU_nuc_hydro PF01156.19 CCF54929.1 - 2.5e-83 280.2 0.0 3.3e-83 279.8 0.0 1.1 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase S1-P1_nuclease PF02265.16 CCF54930.1 - 4.4e-47 161.0 0.0 5e-44 151.0 0.0 2.6 1 1 0 1 1 1 1 S1/P1 Nuclease LRR_6 PF13516.6 CCF54931.1 - 0.0049 16.8 4.5 19 5.6 0.0 5.1 6 0 0 6 6 6 1 Leucine Rich repeat LRR_4 PF12799.7 CCF54931.1 - 0.18 12.2 3.9 4.9 7.7 0.0 3.8 4 1 0 4 4 4 0 Leucine Rich repeats (2 copies) ATP-synt_G PF04718.15 CCF54932.1 - 1.6e-15 57.7 0.2 3.3e-15 56.7 0.0 1.5 2 0 0 2 2 2 1 Mitochondrial ATP synthase g subunit DUF5399 PF17377.2 CCF54932.1 - 0.027 14.3 0.2 0.056 13.3 0.0 1.6 2 0 0 2 2 2 0 Family of unknown function (DUF5399) EF-hand_6 PF13405.6 CCF54933.1 - 4.3e-14 51.2 0.6 1.3e-05 24.7 0.1 3.6 4 0 0 4 4 4 2 EF-hand domain EF-hand_7 PF13499.6 CCF54933.1 - 5.4e-14 52.4 0.2 8.6e-08 32.5 0.1 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 CCF54933.1 - 2.6e-12 45.4 1.8 1.1e-05 24.7 0.1 3.5 5 0 0 5 5 5 2 EF hand EF-hand_8 PF13833.6 CCF54933.1 - 1.7e-06 27.8 0.2 0.0009 19.0 0.0 3.2 2 2 1 3 3 3 2 EF-hand domain pair EF-hand_9 PF14658.6 CCF54933.1 - 1.1e-05 25.7 0.0 0.0011 19.3 0.0 2.2 2 0 0 2 2 2 1 EF-hand domain EF-hand_5 PF13202.6 CCF54933.1 - 0.00011 21.5 0.4 0.0036 16.7 0.2 2.8 2 0 0 2 2 2 1 EF hand EFhand_Ca_insen PF08726.10 CCF54933.1 - 0.0036 17.4 0.0 0.89 9.7 0.0 2.2 2 0 0 2 2 2 2 Ca2+ insensitive EF hand FGAR-AT_linker PF18072.1 CCF54933.1 - 0.18 12.3 0.0 17 6.0 0.0 2.4 2 0 0 2 2 2 0 Formylglycinamide ribonucleotide amidotransferase linker domain DUF3602 PF12223.8 CCF54934.1 - 2.5e-17 63.2 23.0 1.4e-14 54.5 6.0 4.0 2 1 2 4 4 4 3 Protein of unknown function (DUF3602) Mak10 PF04112.13 CCF54935.1 - 4.4e-58 195.5 0.1 8.3e-58 194.6 0.1 1.5 1 0 0 1 1 1 1 Mak10 subunit, NatC N(alpha)-terminal acetyltransferase DEAD PF00270.29 CCF54936.1 - 5.4e-20 71.9 0.0 1.1e-19 70.9 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CCF54936.1 - 0.00048 20.4 0.0 0.0009 19.6 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Fe-S_biosyn PF01521.20 CCF54937.1 - 2.2e-17 63.3 0.0 3.3e-17 62.7 0.0 1.3 1 0 0 1 1 1 1 Iron-sulphur cluster biosynthesis Peptidase_C42 PF05533.12 CCF54937.1 - 0.15 12.1 0.0 0.26 11.3 0.0 1.3 1 0 0 1 1 1 0 Beet yellows virus-type papain-like endopeptidase C42 AAA PF00004.29 CCF54938.1 - 9e-44 149.1 0.0 1.7e-43 148.2 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 CCF54938.1 - 3.7e-10 39.4 0.1 8.1e-10 38.3 0.1 1.6 1 0 0 1 1 1 1 AAA+ lid domain Prot_ATP_ID_OB PF16450.5 CCF54938.1 - 2.8e-08 33.6 2.4 6.5e-08 32.4 2.4 1.7 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_2 PF07724.14 CCF54938.1 - 4.5e-08 33.4 0.0 9.1e-08 32.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 CCF54938.1 - 3.7e-06 27.0 0.0 1.4e-05 25.1 0.0 2.0 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 CCF54938.1 - 5.6e-06 26.8 0.1 7.2e-05 23.2 0.1 2.4 1 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 CCF54938.1 - 1.6e-05 25.2 0.4 0.005 17.1 0.1 2.8 2 1 0 2 2 1 1 AAA domain RuvB_N PF05496.12 CCF54938.1 - 9e-05 22.3 0.0 0.00021 21.1 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain TIP49 PF06068.13 CCF54938.1 - 0.0013 18.0 0.0 0.0026 17.0 0.0 1.5 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_18 PF13238.6 CCF54938.1 - 0.0013 19.2 0.0 0.023 15.2 0.0 2.6 3 0 0 3 3 2 1 AAA domain AAA_33 PF13671.6 CCF54938.1 - 0.0017 18.5 0.0 0.0037 17.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 CCF54938.1 - 0.0023 17.7 0.0 0.005 16.6 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein PhoH PF02562.16 CCF54938.1 - 0.0053 16.2 0.0 0.16 11.4 0.0 2.3 2 0 0 2 2 2 1 PhoH-like protein AAA_28 PF13521.6 CCF54938.1 - 0.0078 16.5 0.2 0.022 15.0 0.0 1.8 2 0 0 2 2 2 1 AAA domain DUF2072 PF09845.9 CCF54938.1 - 0.008 16.4 0.1 0.014 15.6 0.1 1.4 1 0 0 1 1 1 1 Zn-ribbon containing protein Mg_chelatase PF01078.21 CCF54938.1 - 0.0081 15.6 0.1 0.021 14.2 0.1 1.6 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 CCF54938.1 - 0.0092 15.8 0.0 0.018 14.9 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 CCF54938.1 - 0.011 15.5 0.0 0.11 12.2 0.0 2.1 2 0 0 2 2 2 0 AAA domain ATPase PF06745.13 CCF54938.1 - 0.02 14.2 0.0 0.044 13.1 0.0 1.5 1 0 0 1 1 1 0 KaiC TsaE PF02367.17 CCF54938.1 - 0.021 14.8 0.0 0.041 13.9 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Sigma54_activat PF00158.26 CCF54938.1 - 0.028 14.1 0.0 0.12 12.1 0.0 2.0 2 0 0 2 2 2 0 Sigma-54 interaction domain DUF815 PF05673.13 CCF54938.1 - 0.034 13.3 0.0 0.067 12.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_7 PF12775.7 CCF54938.1 - 0.038 13.5 0.0 0.066 12.7 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_14 PF13173.6 CCF54938.1 - 0.051 13.6 0.0 0.088 12.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 CCF54938.1 - 0.053 13.9 0.0 0.094 13.1 0.0 1.4 1 0 0 1 1 1 0 RNA helicase Parvo_NS1 PF01057.17 CCF54938.1 - 0.056 12.5 0.0 0.11 11.6 0.0 1.4 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 TMF_TATA_bd PF12325.8 CCF54938.1 - 0.058 13.6 0.9 0.091 13.0 0.2 1.7 2 0 0 2 2 1 0 TATA element modulatory factor 1 TATA binding AAA_25 PF13481.6 CCF54938.1 - 0.065 12.8 0.0 0.19 11.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.6 CCF54938.1 - 0.079 12.7 0.1 0.46 10.2 0.0 2.0 2 0 0 2 2 2 0 AAA domain RILP PF11461.8 CCF54938.1 - 0.082 13.1 1.0 0.16 12.2 1.0 1.5 1 0 0 1 1 1 0 Rab interacting lysosomal protein FAM199X PF15814.5 CCF54938.1 - 0.094 11.8 0.8 0.16 11.0 0.8 1.3 1 0 0 1 1 1 0 Protein family FAM199X Zeta_toxin PF06414.12 CCF54938.1 - 0.1 11.9 0.0 0.2 10.9 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin NACHT PF05729.12 CCF54938.1 - 0.14 12.0 0.0 0.69 9.8 0.0 2.1 2 0 0 2 2 2 0 NACHT domain AAA_19 PF13245.6 CCF54938.1 - 0.16 12.3 0.3 0.69 10.2 0.0 2.2 2 1 0 2 2 2 0 AAA domain TFIIB_C_1 PF18542.1 CCF54940.1 - 0.17 11.9 0.0 0.23 11.5 0.0 1.2 1 0 0 1 1 1 0 Transcription factor IIB C-terminal module 1 Alpha-L-AF_C PF06964.12 CCF54941.1 - 3e-24 86.0 0.0 5.7e-24 85.1 0.0 1.5 1 0 0 1 1 1 1 Alpha-L-arabinofuranosidase C-terminal domain CBM_4_9 PF02018.17 CCF54941.1 - 1.6e-05 25.2 2.0 8.4e-05 22.9 2.0 2.3 1 1 0 1 1 1 1 Carbohydrate binding domain Ferric_reduct PF01794.19 CCF54942.1 - 4.2e-18 65.7 16.8 4.2e-18 65.7 16.8 2.0 2 0 0 2 2 2 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.12 CCF54942.1 - 4e-13 49.8 0.0 6.1e-13 49.2 0.0 1.2 1 0 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 CCF54942.1 - 1.3e-07 31.7 0.0 2.7e-07 30.7 0.0 1.5 1 0 0 1 1 1 1 FAD-binding domain Ferric_reduct PF01794.19 CCF54943.1 - 1.7e-15 57.2 16.0 4.7e-15 55.8 14.8 2.3 2 0 0 2 2 2 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.12 CCF54943.1 - 2.3e-13 50.6 0.0 4.4e-09 36.7 0.0 2.4 2 0 0 2 2 2 2 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 CCF54943.1 - 3.4e-06 27.1 0.0 2.7e-05 24.2 0.0 2.2 2 0 0 2 2 2 1 FAD-binding domain MFS_1 PF07690.16 CCF54944.1 - 1.1e-15 57.5 19.3 1e-08 34.5 6.0 3.1 2 1 1 3 3 3 3 Major Facilitator Superfamily Sugar_tr PF00083.24 CCF54944.1 - 4.4e-05 22.5 8.3 0.00036 19.5 0.1 2.3 2 0 0 2 2 2 2 Sugar (and other) transporter Complex1_LYR PF05347.15 CCF54947.1 - 1.6e-10 40.9 1.0 2.3e-10 40.3 1.0 1.3 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 CCF54947.1 - 0.044 14.5 0.1 0.061 14.1 0.1 1.3 1 0 0 1 1 1 0 Complex1_LYR-like LRR_9 PF14580.6 CCF54947.1 - 0.092 12.2 0.0 0.11 12.0 0.0 1.1 1 0 0 1 1 1 0 Leucine-rich repeat Intg_mem_TP0381 PF09529.10 CCF54948.1 - 0.023 14.2 3.8 0.053 13.0 3.9 1.3 1 1 0 1 1 1 0 Integral membrane protein (intg_mem_TP0381) DUF805 PF05656.14 CCF54948.1 - 1.2 9.6 8.5 20 5.7 3.9 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF805) SH3_9 PF14604.6 CCF54949.1 - 2.5e-21 75.2 0.2 3.7e-12 45.9 0.0 3.1 3 0 0 3 3 3 2 Variant SH3 domain SH3_1 PF00018.28 CCF54949.1 - 1.7e-16 59.5 0.0 1.7e-07 30.7 0.0 2.6 2 0 0 2 2 2 2 SH3 domain C1_1 PF00130.22 CCF54949.1 - 2.3e-13 49.8 4.0 4.1e-13 49.0 4.0 1.5 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) FCH PF00611.23 CCF54949.1 - 3.9e-13 49.5 3.5 1.5e-12 47.6 0.2 3.1 3 0 0 3 3 3 1 Fes/CIP4, and EFC/F-BAR homology domain SH3_2 PF07653.17 CCF54949.1 - 5e-11 42.1 0.0 8e-05 22.2 0.0 2.6 3 0 0 3 3 3 2 Variant SH3 domain Glyco_hydro_62 PF03664.13 CCF54949.1 - 0.015 14.6 0.1 0.44 9.8 0.0 2.3 2 0 0 2 2 2 0 Glycosyl hydrolase family 62 PsbP PF01789.16 CCF54949.1 - 0.018 15.2 0.1 0.1 12.7 0.1 2.3 2 1 0 2 2 2 0 PsbP SH3_3 PF08239.11 CCF54949.1 - 0.028 14.7 0.0 0.065 13.5 0.0 1.6 1 0 0 1 1 1 0 Bacterial SH3 domain C1_2 PF03107.16 CCF54949.1 - 0.1 13.0 1.3 0.24 11.7 1.3 1.6 1 0 0 1 1 1 0 C1 domain Med9 PF07544.13 CCF54949.1 - 0.11 12.6 0.6 0.34 11.0 0.1 2.1 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 LOH1CR12 PF10158.9 CCF54949.1 - 0.14 12.2 3.4 0.25 11.3 0.1 2.7 3 0 0 3 3 3 0 Tumour suppressor protein FHA PF00498.26 CCF54950.1 - 1.5e-15 57.2 0.0 1.5e-15 57.2 0.0 1.9 2 0 0 2 2 2 1 FHA domain Macoilin PF09726.9 CCF54950.1 - 3.4 6.1 13.8 3.3 6.1 13.8 1.1 1 0 0 1 1 1 0 Macoilin family Fer2_3 PF13085.6 CCF54951.1 - 1.1e-32 112.2 0.0 2.1e-32 111.4 0.0 1.4 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Fer4_17 PF13534.6 CCF54951.1 - 2.8e-09 37.4 7.3 2.8e-09 37.4 7.3 2.1 3 0 0 3 3 3 1 4Fe-4S dicluster domain Fer4_8 PF13183.6 CCF54951.1 - 2.5e-07 31.1 7.4 2.5e-07 31.1 7.4 2.2 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_10 PF13237.6 CCF54951.1 - 5e-06 26.5 3.6 5e-06 26.5 3.6 2.1 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_7 PF12838.7 CCF54951.1 - 0.0019 18.7 6.1 0.0019 18.7 6.1 2.2 2 1 0 2 2 2 1 4Fe-4S dicluster domain Fer2 PF00111.27 CCF54951.1 - 0.0096 15.9 0.5 0.0096 15.9 0.5 2.1 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain Fer4_9 PF13187.6 CCF54951.1 - 0.65 10.2 13.1 0.38 11.0 8.9 2.5 2 1 0 2 2 2 0 4Fe-4S dicluster domain CAP59_mtransfer PF11735.8 CCF54952.1 - 4.2e-77 259.1 0.1 5.3e-77 258.7 0.1 1.1 1 0 0 1 1 1 1 Cryptococcal mannosyltransferase 1 Vps55 PF04133.14 CCF54952.1 - 0.027 14.4 3.0 0.17 11.9 2.8 2.3 3 0 0 3 3 3 0 Vacuolar protein sorting 55 CMAS PF02353.20 CCF54953.1 - 6.2e-66 222.5 0.1 2.5e-53 181.2 0.0 3.0 2 1 0 2 2 2 2 Mycolic acid cyclopropane synthetase Methyltransf_25 PF13649.6 CCF54953.1 - 3.3e-10 40.5 0.0 1.1e-09 38.9 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCF54953.1 - 9.4e-10 38.6 0.0 1.7e-09 37.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCF54953.1 - 8.3e-09 36.0 0.0 2.4e-08 34.5 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCF54953.1 - 2.7e-08 33.7 0.0 6.7e-08 32.5 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Met_10 PF02475.16 CCF54953.1 - 0.00031 20.6 0.0 0.00057 19.7 0.0 1.4 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_12 PF08242.12 CCF54953.1 - 0.0012 19.6 0.0 0.003 18.3 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain DUF3155 PF11352.8 CCF54953.1 - 0.0056 17.1 0.0 0.013 15.9 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3155) GCD14 PF08704.10 CCF54953.1 - 0.011 15.5 0.0 0.02 14.6 0.0 1.4 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit RrnaAD PF00398.20 CCF54953.1 - 0.078 12.0 0.0 0.14 11.2 0.0 1.4 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase PCMT PF01135.19 CCF54953.1 - 0.083 12.6 0.0 0.15 11.8 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) RVT_2 PF07727.14 CCF54956.1 - 0.0002 21.1 0.0 0.00036 20.2 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Retrotran_gag_2 PF14223.6 CCF54957.1 - 0.011 15.4 0.2 0.019 14.6 0.2 1.3 1 0 0 1 1 1 0 gag-polypeptide of LTR copia-type Ribonuclease_3 PF00636.26 CCF54957.1 - 0.035 14.7 0.1 0.064 13.9 0.1 1.4 1 0 0 1 1 1 0 Ribonuclease III domain PCI PF01399.27 CCF54958.1 - 3.7e-07 30.6 0.0 1.5e-06 28.7 0.0 2.0 2 0 0 2 2 2 1 PCI domain SUIM_assoc PF16619.5 CCF54958.1 - 0.0014 18.7 0.0 0.0079 16.2 0.0 2.3 1 1 0 1 1 1 1 Unstructured region C-term to UIM in Ataxin3 Inj_translocase PF16928.5 CCF54958.1 - 0.063 12.7 3.2 0.34 10.3 2.1 2.4 2 0 0 2 2 2 0 DNA/protein translocase of phage P22 injectosome TPR_19 PF14559.6 CCF54958.1 - 0.075 13.6 4.7 0.17 12.4 0.8 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat Spt20 PF12090.8 CCF54958.1 - 0.44 10.1 4.8 0.07 12.7 1.0 1.5 2 0 0 2 2 2 0 Spt20 family TPR_7 PF13176.6 CCF54958.1 - 0.51 10.5 2.6 29 5.0 0.1 3.1 2 0 0 2 2 2 0 Tetratricopeptide repeat LapA_dom PF06305.11 CCF54959.1 - 0.27 11.1 0.4 0.49 10.2 0.4 1.4 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain Tmemb_14 PF03647.13 CCF54960.1 - 2.3e-21 76.3 7.3 2.6e-21 76.2 7.3 1.0 1 0 0 1 1 1 1 Transmembrane proteins 14C TraF_2 PF13729.6 CCF54961.1 - 0.26 10.6 8.4 0.42 9.9 1.6 2.9 2 1 1 3 3 3 0 F plasmid transfer operon, TraF, protein MDH PF02315.16 CCF54961.1 - 0.49 10.5 0.0 0.49 10.5 0.0 2.8 3 0 0 3 3 3 0 Methanol dehydrogenase beta subunit NPV_P10 PF05531.12 CCF54961.1 - 0.49 10.9 10.0 20 5.7 0.0 4.3 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein DUF4407 PF14362.6 CCF54961.1 - 1.6 8.0 43.6 0.13 11.6 5.8 3.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) DUF948 PF06103.11 CCF54961.1 - 1.8 8.9 6.6 79 3.6 0.1 4.2 3 1 1 4 4 4 0 Bacterial protein of unknown function (DUF948) Glyco_hydro_2_C PF02836.17 CCF54962.1 - 4.2e-10 39.2 0.0 7.6e-09 35.1 0.0 2.1 1 1 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Glyco_hydro_2_N PF02837.18 CCF54962.1 - 5.8e-09 36.1 1.0 1.5e-08 34.7 1.0 1.7 1 1 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain Glyco_hydro_2 PF00703.21 CCF54962.1 - 4.3e-05 24.2 0.0 0.00014 22.5 0.0 2.0 1 1 0 1 1 1 1 Glycosyl hydrolases family 2 adh_short_C2 PF13561.6 CCF54966.1 - 6e-55 186.3 0.3 8.1e-55 185.9 0.3 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCF54966.1 - 4.5e-43 147.0 0.3 6.2e-43 146.5 0.3 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CCF54966.1 - 1.1e-09 38.5 0.4 1.6e-09 37.9 0.4 1.3 1 0 0 1 1 1 1 KR domain MTBP_N PF14918.6 CCF54966.1 - 0.17 11.4 0.1 0.36 10.2 0.0 1.5 2 0 0 2 2 2 0 MDM2-binding Fer2 PF00111.27 CCF54967.1 - 2.1e-11 43.6 0.5 3.2e-11 43.0 0.5 1.3 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain ProRS-C_1 PF09180.11 CCF54968.1 - 2.9e-24 85.0 1.9 2.9e-24 85.0 1.9 1.8 2 0 0 2 2 2 1 Prolyl-tRNA synthetase, C-terminal HGTP_anticodon PF03129.20 CCF54968.1 - 3.3e-19 68.8 0.0 1.2e-18 67.1 0.0 2.0 2 0 0 2 2 2 1 Anticodon binding domain tRNA-synt_2b PF00587.25 CCF54968.1 - 1.7e-16 60.7 0.0 3.2e-16 59.8 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) tRNA_edit PF04073.15 CCF54968.1 - 2.9e-16 59.7 0.5 4.8e-16 58.9 0.5 1.4 1 0 0 1 1 1 1 Aminoacyl-tRNA editing domain CelD_N PF02927.14 CCF54968.1 - 0.22 12.4 1.3 1 10.3 0.0 2.4 2 0 0 2 2 2 0 Cellulase N-terminal ig-like domain zf-CCHC PF00098.23 CCF54969.1 - 3.9e-51 169.0 65.2 1.2e-08 34.6 1.9 7.1 7 0 0 7 7 7 7 Zinc knuckle zf-CCHC_3 PF13917.6 CCF54969.1 - 4.2e-09 36.2 42.7 0.32 11.0 1.2 7.1 3 2 4 7 7 7 7 Zinc knuckle zf-CCHC_4 PF14392.6 CCF54969.1 - 6.7e-09 35.3 43.5 0.028 14.1 0.6 7.1 7 0 0 7 7 7 7 Zinc knuckle zf-CCHC_2 PF13696.6 CCF54969.1 - 0.011 15.6 0.5 0.011 15.6 0.5 7.4 7 0 0 7 7 7 0 Zinc knuckle zf-CCHC_5 PF14787.6 CCF54969.1 - 0.029 14.1 40.8 0.43 10.3 2.6 7.0 7 0 0 7 7 7 0 GAG-polyprotein viral zinc-finger SKN1 PF03935.15 CCF54971.1 - 6.3e-205 681.3 0.6 7.7e-205 681.0 0.6 1.1 1 0 0 1 1 1 1 Beta-glucan synthesis-associated protein (SKN1) MF_alpha_N PF05436.11 CCF54971.1 - 0.2 11.6 0.1 0.48 10.4 0.1 1.6 1 0 0 1 1 1 0 Mating factor alpha precursor N-terminus THOC7 PF05615.13 CCF54972.1 - 8.2e-22 77.9 13.8 1.4e-21 77.2 8.5 2.2 1 1 1 2 2 2 2 Tho complex subunit 7 KxDL PF10241.9 CCF54972.1 - 0.012 15.9 1.1 0.23 11.8 0.1 2.6 3 1 0 3 3 3 0 Uncharacterized conserved protein Snapin_Pallidin PF14712.6 CCF54972.1 - 0.032 14.7 2.4 0.8 10.2 0.4 2.6 2 1 0 2 2 2 0 Snapin/Pallidin GTP-bdg_M PF16360.5 CCF54972.1 - 0.11 13.1 10.0 1.3 9.7 0.5 4.2 3 0 0 3 3 3 0 GTP-binding GTPase Middle Region Matrilin_ccoil PF10393.9 CCF54972.1 - 0.14 12.0 2.0 0.54 10.2 0.1 2.8 3 1 0 3 3 3 0 Trimeric coiled-coil oligomerisation domain of matrilin DUF1664 PF07889.12 CCF54972.1 - 0.24 11.4 2.5 3 7.9 1.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) DUF848 PF05852.11 CCF54972.1 - 0.65 10.1 6.8 0.15 12.1 0.6 2.4 1 1 1 3 3 3 0 Gammaherpesvirus protein of unknown function (DUF848) CENP-H PF05837.12 CCF54972.1 - 0.84 10.1 6.2 5.6 7.4 6.0 2.3 1 1 1 2 2 2 0 Centromere protein H (CENP-H) Med21 PF11221.8 CCF54972.1 - 0.85 9.9 11.3 1.7 8.9 1.4 2.8 2 1 1 3 3 3 0 Subunit 21 of Mediator complex Cnn_1N PF07989.11 CCF54972.1 - 1.5 9.0 8.6 11 6.2 3.6 3.0 2 1 1 3 3 3 0 Centrosomin N-terminal motif 1 FUSC PF04632.12 CCF54972.1 - 4.2 5.8 5.1 5.9 5.3 5.1 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family Lebercilin PF15619.6 CCF54972.1 - 6.8 6.3 15.0 6.5 6.4 8.2 2.7 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease ZapB PF06005.12 CCF54972.1 - 7.1 7.1 9.6 11 6.6 0.5 2.9 3 0 0 3 3 3 0 Cell division protein ZapB Fungal_TACC PF12709.7 CCF54972.1 - 7.2 7.1 8.3 0.38 11.2 0.4 2.6 3 1 1 4 4 4 0 Fungal Transforming acidic coiled-coil (TACC) proteins UCH PF00443.29 CCF54974.1 - 5.3e-37 127.7 0.0 1.3e-33 116.6 0.0 2.3 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 CCF54974.1 - 0.063 12.9 0.2 2.8 7.4 0.0 2.7 3 0 0 3 3 3 0 Ubiquitin carboxyl-terminal hydrolase Paf1 PF03985.13 CCF54974.1 - 1.9 7.4 4.5 4.1 6.3 4.5 1.5 1 0 0 1 1 1 0 Paf1 Ribosomal_L14e PF01929.17 CCF54975.1 - 2.8e-30 104.6 0.7 3.7e-30 104.3 0.7 1.1 1 0 0 1 1 1 1 Ribosomal protein L14 KOW PF00467.29 CCF54975.1 - 6.4e-05 22.7 0.5 0.00011 22.0 0.5 1.4 1 0 0 1 1 1 1 KOW motif Ribosomal_L44 PF00935.19 CCF54976.1 - 1.1e-35 122.0 13.0 1.6e-35 121.4 13.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L44 RAC_head PF16717.5 CCF54977.1 - 6.2e-20 72.0 9.6 6.2e-20 72.0 9.6 3.1 4 0 0 4 4 4 1 Ribosome-associated complex head domain DnaJ PF00226.31 CCF54977.1 - 4.9e-18 65.0 0.1 4.9e-18 65.0 0.1 2.1 2 1 0 2 2 2 1 DnaJ domain Presenilin PF01080.17 CCF54977.1 - 6.7 5.4 9.3 11 4.7 9.3 1.3 1 0 0 1 1 1 0 Presenilin tRNA-synt_2b PF00587.25 CCF54978.1 - 3.2e-38 131.5 0.0 7.5e-38 130.3 0.0 1.6 2 0 0 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.22 CCF54978.1 - 1.5e-19 70.2 10.4 1.5e-19 70.2 10.4 1.8 2 0 0 2 2 2 1 Seryl-tRNA synthetase N-terminal domain MIP-T3_C PF17749.1 CCF54978.1 - 0.00035 20.5 5.4 0.00068 19.6 5.4 1.4 1 0 0 1 1 1 1 Microtubule-binding protein MIP-T3 C-terminal region Myosin_tail_1 PF01576.19 CCF54978.1 - 0.0017 16.3 5.0 0.0023 15.8 5.0 1.1 1 0 0 1 1 1 1 Myosin tail DUF724 PF05266.14 CCF54978.1 - 0.014 15.2 4.0 0.034 14.0 4.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF724) NuA4 PF09340.10 CCF54978.1 - 0.024 14.5 0.5 0.088 12.7 0.1 2.3 2 0 0 2 2 2 0 Histone acetyltransferase subunit NuA4 tRNA-synt_His PF13393.6 CCF54978.1 - 0.12 11.6 0.9 0.44 9.8 0.0 1.9 2 0 0 2 2 2 0 Histidyl-tRNA synthetase FAM76 PF16046.5 CCF54978.1 - 0.37 10.1 4.1 0.74 9.1 4.1 1.5 1 0 0 1 1 1 0 FAM76 protein YPEB PF14620.6 CCF54978.1 - 0.7 9.2 8.5 1.7 7.9 8.5 1.6 1 1 0 1 1 1 0 YpeB sporulation TMPIT PF07851.13 CCF54978.1 - 2.9 7.0 5.3 4.8 6.3 5.3 1.2 1 0 0 1 1 1 0 TMPIT-like protein BRE1 PF08647.11 CCF54978.1 - 5.7 7.1 13.1 15 5.8 13.1 1.6 1 0 0 1 1 1 0 BRE1 E3 ubiquitin ligase Glyco_hydro_8 PF01270.17 CCF54979.1 - 1.7e-18 66.6 0.0 2.7e-18 65.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 8 RTBV_P12 PF06361.11 CCF54980.1 - 1.2 9.5 3.8 0.36 11.2 0.5 1.8 2 0 0 2 2 2 0 Rice tungro bacilliform virus P12 protein Ribosomal_S8 PF00410.19 CCF54981.1 - 3.1e-21 75.6 0.0 4.2e-21 75.2 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein S8 Ribosomal_S17e PF00833.18 CCF54982.1 - 3.6e-59 198.0 0.0 4.2e-59 197.8 0.0 1.0 1 0 0 1 1 1 1 Ribosomal S17 DNA_pol_A_exo1 PF01612.20 CCF54983.1 - 9.1e-16 58.1 0.0 1.7e-15 57.2 0.0 1.4 1 0 0 1 1 1 1 3'-5' exonuclease HTH_40 PF14493.6 CCF54983.1 - 0.0076 16.7 0.0 0.025 15.0 0.0 1.9 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_3 PF01381.22 CCF54983.1 - 0.13 12.3 0.4 70 3.6 0.1 3.6 3 0 0 3 3 3 0 Helix-turn-helix Trypan_PARP PF05887.11 CCF54983.1 - 1.1 9.2 9.7 0.23 11.5 2.5 2.3 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) Prefoldin_2 PF01920.20 CCF54984.1 - 2.9e-22 78.6 12.7 3.4e-22 78.4 12.7 1.0 1 0 0 1 1 1 1 Prefoldin subunit Macoilin PF09726.9 CCF54984.1 - 0.0099 14.5 8.3 0.011 14.4 8.3 1.0 1 0 0 1 1 1 1 Macoilin family Rx_N PF18052.1 CCF54984.1 - 0.022 15.1 1.0 0.022 15.1 1.0 2.0 2 0 0 2 2 2 0 Rx N-terminal domain DUF1192 PF06698.11 CCF54984.1 - 0.023 14.7 1.9 0.023 14.7 1.9 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1192) Rh5 PF18515.1 CCF54984.1 - 0.03 13.6 1.3 0.034 13.5 1.3 1.2 1 0 0 1 1 1 0 Rh5 coiled-coil domain YabA PF06156.13 CCF54984.1 - 0.034 14.8 4.3 0.29 11.8 0.5 2.1 2 0 0 2 2 2 0 Initiation control protein YabA DUF4349 PF14257.6 CCF54984.1 - 0.072 12.5 6.7 0.019 14.4 3.0 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4349) TMF_TATA_bd PF12325.8 CCF54984.1 - 0.25 11.6 7.3 0.14 12.4 1.5 2.1 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding Syntaxin-6_N PF09177.11 CCF54984.1 - 0.28 11.8 4.9 0.37 11.4 4.9 1.2 1 0 0 1 1 1 0 Syntaxin 6, N-terminal Occludin_ELL PF07303.13 CCF54984.1 - 0.29 11.9 5.4 0.29 11.9 1.5 2.0 1 1 1 2 2 2 0 Occludin homology domain Fib_alpha PF08702.10 CCF54984.1 - 0.33 11.1 8.9 0.71 10.0 8.9 1.5 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family PHM7_cyt PF14703.6 CCF54984.1 - 0.65 10.2 6.5 1.9 8.7 6.5 1.7 1 1 0 1 1 1 0 Cytosolic domain of 10TM putative phosphate transporter Prefoldin PF02996.17 CCF54984.1 - 0.78 9.7 11.1 0.19 11.7 4.4 2.1 1 1 1 2 2 2 0 Prefoldin subunit EzrA PF06160.12 CCF54984.1 - 0.9 7.6 11.5 0.31 9.2 4.8 2.0 1 1 1 2 2 2 0 Septation ring formation regulator, EzrA DUF4407 PF14362.6 CCF54984.1 - 1.1 8.6 10.9 0.049 13.0 2.3 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) ADIP PF11559.8 CCF54984.1 - 1.8 8.6 11.6 0.11 12.6 3.2 2.0 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding Snf7 PF03357.21 CCF54984.1 - 2 8.0 12.1 0.16 11.6 6.4 1.8 2 0 0 2 2 2 0 Snf7 Osmo_CC PF08946.10 CCF54984.1 - 2.3 8.5 9.2 0.29 11.4 3.5 2.4 2 1 1 3 3 3 0 Osmosensory transporter coiled coil Spc24 PF08286.11 CCF54984.1 - 2.9 8.2 7.1 4.7 7.5 1.2 2.1 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 DUF4200 PF13863.6 CCF54984.1 - 5.4 7.4 15.0 13 6.2 14.7 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4200) APG6_N PF17675.1 CCF54984.1 - 5.8 7.4 13.3 70 3.9 13.0 1.9 1 1 0 1 1 1 0 Apg6 coiled-coil region ZapB PF06005.12 CCF54984.1 - 6.2 7.3 14.3 4.9 7.7 4.8 2.2 1 1 1 2 2 2 0 Cell division protein ZapB ABC_tran_CTD PF16326.5 CCF54984.1 - 8.3 6.7 10.4 2.4 8.4 3.2 2.5 2 1 0 2 2 2 0 ABC transporter C-terminal domain Lge1 PF11488.8 CCF54984.1 - 8.9 6.6 10.5 3.5 7.9 4.9 2.3 1 1 1 2 2 2 0 Transcriptional regulatory protein LGE1 COG2 PF06148.11 CCF54984.1 - 9.1 6.4 9.5 1.7 8.8 3.1 2.0 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 UPF0242 PF06785.11 CCF54984.1 - 9.5 6.3 12.5 14 5.7 12.5 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus RNA_lig_T4_1 PF09511.10 CCF54985.1 - 4.9e-81 271.8 0.0 9.6e-81 270.8 0.0 1.5 1 0 0 1 1 1 1 RNA ligase tRNA_lig_CPD PF08302.11 CCF54985.1 - 1.2e-38 133.1 0.0 1.9e-38 132.4 0.0 1.3 1 0 0 1 1 1 1 Fungal tRNA ligase phosphodiesterase domain tRNA_lig_kinase PF08303.11 CCF54985.1 - 4.3e-21 75.7 0.0 8.7e-21 74.7 0.0 1.5 1 0 0 1 1 1 1 tRNA ligase kinase domain AAA PF00004.29 CCF54985.1 - 0.17 12.3 0.0 0.48 10.9 0.0 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Ecl1 PF12855.7 CCF54986.1 - 0.0046 18.1 5.9 0.0046 18.1 5.9 8.8 3 3 1 6 6 6 1 ECL1/2/3 zinc binding proteins AA_kinase PF00696.28 CCF54988.1 - 2.5e-39 135.3 1.4 2.7e-33 115.6 0.1 2.8 3 0 0 3 3 3 2 Amino acid kinase family ACT PF01842.25 CCF54988.1 - 2.3e-12 46.4 0.2 3.7e-06 26.6 0.1 2.8 2 0 0 2 2 2 2 ACT domain ACT_7 PF13840.6 CCF54988.1 - 1.5e-09 37.5 1.5 9.4e-07 28.5 0.2 2.6 2 0 0 2 2 2 2 ACT domain DUF4226 PF10774.9 CCF54988.1 - 0.012 15.9 0.2 0.031 14.6 0.2 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4226) WH2 PF02205.20 CCF54990.1 - 7.9e-06 25.5 0.5 1.9e-05 24.3 0.5 1.7 1 0 0 1 1 1 1 WH2 motif Cellulase PF00150.18 CCF54992.1 - 3.8e-11 42.9 10.8 1.7e-10 40.8 10.8 2.0 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) PrmA PF06325.13 CCF54994.1 - 7.3e-05 22.3 0.1 0.00019 21.0 0.1 1.7 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_23 PF13489.6 CCF54994.1 - 0.00031 20.6 0.0 0.00059 19.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCF54994.1 - 0.00047 20.8 0.0 0.053 14.2 0.0 2.9 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_32 PF13679.6 CCF54994.1 - 0.011 15.8 0.1 0.019 15.0 0.1 1.4 1 0 0 1 1 1 0 Methyltransferase domain Cons_hypoth95 PF03602.15 CCF54994.1 - 0.022 14.4 0.4 0.038 13.6 0.4 1.3 1 0 0 1 1 1 0 Conserved hypothetical protein 95 MTS PF05175.14 CCF54994.1 - 0.024 14.2 0.0 0.05 13.2 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_9 PF08003.11 CCF54994.1 - 0.029 13.3 0.0 0.047 12.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) DREV PF05219.12 CCF54994.1 - 0.042 12.9 0.0 0.07 12.2 0.0 1.3 1 0 0 1 1 1 0 DREV methyltransferase Methyltransf_11 PF08241.12 CCF54994.1 - 0.08 13.6 0.1 1.9 9.2 0.0 2.6 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_16 PF10294.9 CCF54994.1 - 0.081 12.7 0.1 0.13 11.9 0.1 1.3 1 0 0 1 1 1 0 Lysine methyltransferase Methyltransf_31 PF13847.6 CCF54994.1 - 0.11 12.3 0.0 0.98 9.2 0.0 2.3 2 0 0 2 2 2 0 Methyltransferase domain Bromodomain PF00439.25 CCF54995.1 - 7.2e-17 61.2 0.0 1.3e-16 60.5 0.0 1.4 1 0 0 1 1 1 1 Bromodomain XhlA PF10779.9 CCF54995.1 - 1.9 8.7 5.1 0.9 9.8 1.2 2.3 2 0 0 2 2 2 0 Haemolysin XhlA DUF1515 PF07439.11 CCF54995.1 - 3.9 7.5 5.9 12 5.9 1.4 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1515) adh_short PF00106.25 CCF54996.1 - 1.5e-15 57.2 0.0 1.1e-09 38.0 0.0 3.1 2 1 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CCF54996.1 - 2.7e-09 36.9 0.0 3.9e-07 29.9 0.0 2.4 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCF54996.1 - 0.00014 21.8 0.0 0.00034 20.6 0.0 1.6 2 0 0 2 2 2 1 KR domain Dus PF01207.17 CCF54997.1 - 1.2e-68 231.5 0.0 4e-67 226.5 0.0 2.0 1 1 0 1 1 1 1 Dihydrouridine synthase (Dus) NMO PF03060.15 CCF54997.1 - 0.021 14.2 0.1 0.034 13.6 0.1 1.2 1 0 0 1 1 1 0 Nitronate monooxygenase YTH PF04146.15 CCF54998.1 - 4.8e-59 199.0 9.1 4.2e-58 196.0 9.1 2.4 1 1 0 1 1 1 1 YT521-B-like domain RRM_1 PF00076.22 CCF54998.1 - 0.0019 18.0 0.0 1.9 8.4 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Peptidase_C41 PF05417.11 CCF54998.1 - 0.11 12.3 0.0 0.2 11.5 0.0 1.3 1 0 0 1 1 1 0 Hepatitis E cysteine protease # # Program: hmmscan # Version: 3.2.1 (June 2018) # Pipeline mode: SCAN # Query file: /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Ustilago_hordei-ASM28603v1/GCA_000286035.1_ASM28603v1_protein.faa # Target file: /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm # Option settings: /oak/stanford/groups/akundaje/marinovg/programs/hmmer-3.2.1/bin/hmmscan -o /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Ustilago_hordei-ASM28603v1/GCA_000286035.1_ASM28603v1_protein.PFam32-A --tblout /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Ustilago_hordei-ASM28603v1/GCA_000286035.1_ASM28603v1_protein.PFam32-A.tblout --cpu 20 /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Ustilago_hordei-ASM28603v1/GCA_000286035.1_ASM28603v1_protein.faa # Current dir: /oak/stanford/groups/akundaje/marinovg/genomes # Date: Mon Mar 25 07:45:30 2019 # [ok]