# --- full sequence ---- --- best 1 domain ---- --- domain number estimation ---- # target name accession query name accession E-value score bias E-value score bias exp reg clu ov env dom rep inc description of target #------------------- ---------- -------------------- ---------- --------- ------ ----- --------- ------ ----- --- --- --- --- --- --- --- --- --------------------- Pkinase PF00069.25 EGD92423.1 - 1.4e-13 50.8 0.0 3.7e-13 49.4 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD92423.1 - 1.7e-08 34.0 0.0 3.6e-08 33.0 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Choline_kinase PF01633.20 EGD92423.1 - 0.00057 19.5 0.0 0.0014 18.3 0.0 1.5 2 0 0 2 2 2 1 Choline/ethanolamine kinase APH PF01636.23 EGD92423.1 - 0.0019 18.2 0.1 0.011 15.7 0.1 1.8 1 1 1 2 2 2 1 Phosphotransferase enzyme family SpoVAD PF07451.11 EGD92423.1 - 0.29 9.8 0.1 0.73 8.5 0.1 1.6 2 0 0 2 2 2 0 Stage V sporulation protein AD (SpoVAD) GTP_cyclohydro2 PF00925.20 EGD92426.1 - 3e-57 192.7 0.0 4.1e-57 192.3 0.0 1.1 1 0 0 1 1 1 1 GTP cyclohydrolase II DUF1325 PF07039.11 EGD92427.1 - 5.2e-34 117.2 0.0 1.1e-33 116.1 0.0 1.6 1 0 0 1 1 1 1 SGF29 tudor-like domain LBR_tudor PF09465.10 EGD92427.1 - 0.0043 16.8 0.0 0.0079 16.0 0.0 1.4 1 0 0 1 1 1 1 Lamin-B receptor of TUDOR domain MS_channel PF00924.18 EGD92427.1 - 0.23 11.0 0.1 0.36 10.3 0.1 1.3 1 0 0 1 1 1 0 Mechanosensitive ion channel PMI_typeI PF01238.21 EGD92428.1 - 9.1e-148 492.4 0.0 1.1e-147 492.1 0.0 1.1 1 0 0 1 1 1 1 Phosphomannose isomerase type I AraC_binding PF02311.19 EGD92428.1 - 0.023 14.6 0.0 3.6 7.5 0.0 2.6 2 0 0 2 2 2 0 AraC-like ligand binding domain Abhydrolase_3 PF07859.13 EGD92429.1 - 4e-25 88.9 0.0 9.6e-25 87.7 0.0 1.5 2 0 0 2 2 2 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 EGD92429.1 - 1.2e-23 83.6 0.0 1.5e-23 83.3 0.0 1.1 1 0 0 1 1 1 1 Steryl acetyl hydrolase Peptidase_S9 PF00326.21 EGD92429.1 - 0.0074 15.8 0.0 0.36 10.3 0.0 2.5 3 0 0 3 3 3 1 Prolyl oligopeptidase family DUF2974 PF11187.8 EGD92429.1 - 0.042 13.4 0.0 0.1 12.1 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2974) Abhydrolase_2 PF02230.16 EGD92429.1 - 0.071 12.9 0.0 2.9 7.6 0.0 2.9 3 0 0 3 3 3 0 Phospholipase/Carboxylesterase Coatomer_E PF04733.14 EGD92430.1 - 4.1e-65 220.1 6.8 4.7e-65 219.9 6.8 1.0 1 0 0 1 1 1 1 Coatomer epsilon subunit TPR_19 PF14559.6 EGD92430.1 - 2e-07 31.4 22.6 0.00056 20.4 3.5 4.5 2 1 2 4 4 4 3 Tetratricopeptide repeat ANAPC3 PF12895.7 EGD92430.1 - 9.8e-07 28.9 5.6 0.019 15.2 1.1 3.3 3 0 0 3 3 3 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_16 PF13432.6 EGD92430.1 - 1.3e-06 28.9 20.4 0.0027 18.3 0.2 4.7 4 1 0 5 5 5 2 Tetratricopeptide repeat TPR_14 PF13428.6 EGD92430.1 - 0.00019 22.0 22.1 0.0092 16.7 0.1 5.4 5 1 1 6 6 5 2 Tetratricopeptide repeat TPR_12 PF13424.6 EGD92430.1 - 0.00021 21.5 14.3 0.095 13.0 2.5 4.4 3 2 1 4 4 4 2 Tetratricopeptide repeat TPR_6 PF13174.6 EGD92430.1 - 0.007 16.9 4.3 0.23 12.2 0.0 4.5 5 0 0 5 5 4 1 Tetratricopeptide repeat Peptidase_S11 PF00768.20 EGD92430.1 - 0.0087 15.5 0.2 0.011 15.2 0.2 1.2 1 0 0 1 1 1 1 D-alanyl-D-alanine carboxypeptidase TPR_2 PF07719.17 EGD92430.1 - 0.052 13.7 0.0 0.052 13.7 0.0 5.4 6 0 0 6 6 5 0 Tetratricopeptide repeat TPR_9 PF13371.6 EGD92430.1 - 0.097 12.8 5.5 0.18 12.0 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TF_AP-2 PF03299.14 EGD92430.1 - 0.097 12.6 0.4 0.15 12.0 0.4 1.3 1 0 0 1 1 1 0 Transcription factor AP-2 TPR_1 PF00515.28 EGD92430.1 - 0.11 12.4 5.4 0.48 10.3 0.0 4.1 5 0 0 5 5 5 0 Tetratricopeptide repeat TetR_C_25 PF17933.1 EGD92430.1 - 0.11 12.9 0.6 0.28 11.5 0.6 1.7 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain Type_III_YscG PF09477.10 EGD92430.1 - 0.62 10.2 7.5 1.3 9.1 3.3 3.0 1 1 2 3 3 3 0 Bacterial type II secretion system chaperone protein (type_III_yscG) TPR_4 PF07721.14 EGD92430.1 - 1.3 9.9 24.1 0.26 12.0 0.7 5.6 7 0 0 7 7 6 0 Tetratricopeptide repeat TPR_10 PF13374.6 EGD92430.1 - 2 8.4 8.1 13 5.8 0.1 4.5 4 0 0 4 4 4 0 Tetratricopeptide repeat Fungal_trans PF04082.18 EGD92431.1 - 9.6e-09 34.6 0.0 1.6e-08 33.9 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EGD92431.1 - 1.1e-07 31.8 11.1 2.1e-07 30.9 11.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Dynamitin PF04912.14 EGD92431.1 - 0.071 12.4 0.0 0.12 11.7 0.0 1.2 1 0 0 1 1 1 0 Dynamitin Methyltransf_23 PF13489.6 EGD92432.1 - 8e-15 55.0 0.0 1.1e-14 54.6 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EGD92432.1 - 2.6e-11 44.0 0.0 8.2e-11 42.4 0.0 1.9 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EGD92432.1 - 6.8e-10 38.9 0.0 3e-09 36.9 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EGD92432.1 - 7.4e-10 39.4 0.0 4.9e-09 36.8 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EGD92432.1 - 5.2e-09 36.8 0.0 9.9e-09 35.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain DREV PF05219.12 EGD92432.1 - 4.8e-06 25.9 0.0 5.9e-06 25.6 0.0 1.2 1 0 0 1 1 1 1 DREV methyltransferase MTS PF05175.14 EGD92432.1 - 0.019 14.5 0.0 0.036 13.6 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_32 PF13679.6 EGD92432.1 - 0.041 13.9 0.0 0.062 13.3 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Ubie_methyltran PF01209.18 EGD92432.1 - 0.043 13.1 0.0 0.52 9.6 0.0 2.5 2 1 0 2 2 2 0 ubiE/COQ5 methyltransferase family Methyltransf_19 PF04672.12 EGD92432.1 - 0.066 12.7 0.0 0.09 12.2 0.0 1.1 1 0 0 1 1 1 0 S-adenosyl methyltransferase Fungal_trans PF04082.18 EGD92433.1 - 3.6e-10 39.3 0.0 8.4e-10 38.1 0.0 1.4 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EGD92433.1 - 1.5e-07 31.4 6.9 1.5e-07 31.4 6.9 2.2 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF3425 PF11905.8 EGD92434.1 - 4.8e-23 81.5 1.4 8.1e-23 80.7 1.4 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3425) G_path_suppress PF15991.5 EGD92434.1 - 0.042 14.0 8.3 0.072 13.2 8.3 1.3 1 0 0 1 1 1 0 G-protein pathway suppressor BMFP PF04380.13 EGD92434.1 - 0.047 14.2 0.6 0.1 13.1 0.6 1.6 1 0 0 1 1 1 0 Membrane fusogenic activity bZIP_1 PF00170.21 EGD92434.1 - 0.11 12.6 11.1 0.083 13.0 8.5 2.0 1 1 1 2 2 2 0 bZIP transcription factor Actin PF00022.19 EGD92435.1 - 5.4e-112 374.4 0.0 3.8e-111 371.6 0.0 1.8 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 EGD92435.1 - 0.068 12.0 0.0 0.43 9.4 0.0 2.2 1 1 0 1 1 1 0 MreB/Mbl protein EamA PF00892.20 EGD92436.1 - 1.9e-09 37.8 29.2 3.5e-05 24.0 2.3 2.9 3 0 0 3 3 3 2 EamA-like transporter family Aldo_ket_red PF00248.21 EGD92437.1 - 2.5e-53 181.2 0.0 2.8e-53 181.0 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Tubulin PF00091.25 EGD92438.1 - 9.8e-61 205.4 0.0 1.5e-60 204.8 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EGD92438.1 - 7.5e-43 145.7 0.6 1.6e-42 144.6 0.1 1.7 2 0 0 2 2 2 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 EGD92438.1 - 0.057 13.1 0.0 0.14 11.9 0.0 1.6 2 0 0 2 2 2 0 Tubulin domain Hrs_helical PF12210.8 EGD92438.1 - 0.12 12.9 0.4 0.37 11.4 0.0 1.9 2 0 0 2 2 2 0 Hepatocyte growth factor-regulated tyrosine kinase substrate Tubulin_2 PF13809.6 EGD92438.1 - 0.13 11.4 0.0 0.17 11.0 0.0 1.3 1 0 0 1 1 1 0 Tubulin like DEAD_2 PF06733.15 EGD92438.1 - 0.19 11.4 0.0 0.39 10.3 0.0 1.4 1 0 0 1 1 1 0 DEAD_2 Aa_trans PF01490.18 EGD92439.1 - 6.2e-39 133.9 38.8 7.4e-39 133.6 38.8 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Crystall PF00030.19 EGD92440.1 - 0.0047 17.1 0.0 0.0063 16.7 0.0 1.2 1 0 0 1 1 1 1 Beta/Gamma crystallin DUF883 PF05957.13 EGD92441.1 - 0.017 15.7 0.1 0.017 15.7 0.1 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF883) HOIP-UBA PF16678.5 EGD92441.1 - 0.019 15.0 0.3 0.021 14.8 0.3 1.0 1 0 0 1 1 1 0 HOIP UBA domain pair YtxH PF12732.7 EGD92441.1 - 0.02 15.4 2.8 0.025 15.1 2.8 1.3 1 1 0 1 1 1 0 YtxH-like protein WXG100 PF06013.12 EGD92441.1 - 0.033 14.4 1.5 0.038 14.2 1.5 1.1 1 0 0 1 1 1 0 Proteins of 100 residues with WXG ISG65-75 PF11727.8 EGD92441.1 - 0.069 12.4 2.1 0.075 12.2 2.1 1.1 1 0 0 1 1 1 0 Invariant surface glycoprotein DUF4527 PF15030.6 EGD92441.1 - 0.077 12.4 0.3 0.077 12.4 0.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4527) HSP9_HSP12 PF04119.12 EGD92441.1 - 0.15 12.4 4.9 0.28 11.6 4.9 1.6 1 1 0 1 1 1 0 Heat shock protein 9/12 XhlA PF10779.9 EGD92441.1 - 0.18 12.0 0.2 0.26 11.5 0.2 1.3 1 0 0 1 1 1 0 Haemolysin XhlA CsbD PF05532.12 EGD92441.1 - 1.2 9.0 11.4 16 5.5 11.4 2.4 1 1 0 1 1 1 0 CsbD-like Robl_LC7 PF03259.17 EGD92442.1 - 4.3e-05 23.2 0.1 0.38 10.5 0.0 3.2 3 0 0 3 3 3 3 Roadblock/LC7 domain Ipi1_N PF12333.8 EGD92443.1 - 3e-27 95.2 0.2 3e-27 95.2 0.2 2.6 2 1 0 2 2 2 1 Rix1 complex component involved in 60S ribosome maturation F-box PF00646.33 EGD92444.1 - 0.0012 18.7 0.2 0.0065 16.3 0.1 2.2 2 0 0 2 2 2 1 F-box domain Pyrid_oxidase_2 PF13883.6 EGD92445.1 - 6.2e-36 123.9 0.0 1e-35 123.2 0.0 1.3 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Putative_PNPOx PF01243.20 EGD92445.1 - 0.059 13.6 0.0 0.33 11.2 0.0 2.0 1 1 0 1 1 1 0 Pyridoxamine 5'-phosphate oxidase DUF1771 PF08590.10 EGD92447.1 - 2.8e-25 88.5 8.5 1e-24 86.6 5.5 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF1771) Smr PF01713.21 EGD92447.1 - 2.2e-10 40.7 0.4 2.2e-10 40.7 0.4 2.1 2 0 0 2 2 2 1 Smr domain Connexin43 PF03508.13 EGD92447.1 - 0.62 9.7 3.3 0.45 10.1 0.8 1.9 2 0 0 2 2 2 0 Gap junction alpha-1 protein (Cx43) DUF4407 PF14362.6 EGD92447.1 - 1.1 8.5 3.6 1.5 8.1 3.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) polyprenyl_synt PF00348.17 EGD92448.1 - 1e-67 227.9 0.0 1.5e-67 227.4 0.0 1.2 1 0 0 1 1 1 1 Polyprenyl synthetase SQS_PSY PF00494.19 EGD92450.1 - 4.7e-59 200.0 0.0 5.8e-59 199.7 0.0 1.1 1 0 0 1 1 1 1 Squalene/phytoene synthase RPE65 PF03055.15 EGD92451.1 - 2.4e-116 389.7 0.0 2.8e-116 389.5 0.0 1.0 1 0 0 1 1 1 1 Retinal pigment epithelial membrane protein Amino_oxidase PF01593.24 EGD92452.1 - 1.1e-26 94.2 0.0 3.3e-26 92.6 0.0 1.8 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EGD92452.1 - 2.4e-14 53.3 0.1 8e-14 51.6 0.0 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EGD92452.1 - 2.2e-08 34.1 0.1 2e-07 30.9 0.1 2.0 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EGD92452.1 - 5.5e-08 32.4 0.0 1.2e-05 24.8 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EGD92452.1 - 1.6e-07 30.4 0.2 0.0021 16.8 1.1 2.2 2 0 0 2 2 2 2 HI0933-like protein FAD_binding_2 PF00890.24 EGD92452.1 - 1.2e-05 24.6 0.8 9.7e-05 21.6 2.1 1.8 2 0 0 2 2 2 1 FAD binding domain FAD_oxidored PF12831.7 EGD92452.1 - 0.00015 21.3 2.9 0.00043 19.8 2.7 1.7 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 EGD92452.1 - 0.00056 19.2 0.6 0.0012 18.2 0.3 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EGD92452.1 - 0.00068 19.7 0.7 0.061 13.3 0.4 2.4 2 0 0 2 2 2 1 FAD-NAD(P)-binding GDI PF00996.18 EGD92452.1 - 0.0021 16.7 0.1 0.028 12.9 0.0 2.1 2 0 0 2 2 2 1 GDP dissociation inhibitor Thi4 PF01946.17 EGD92452.1 - 0.0029 16.9 0.7 0.0048 16.2 0.4 1.5 2 0 0 2 2 2 1 Thi4 family FAD_binding_3 PF01494.19 EGD92452.1 - 0.0052 16.1 0.2 0.0099 15.2 0.2 1.4 1 0 0 1 1 1 1 FAD binding domain Pyr_redox PF00070.27 EGD92452.1 - 0.029 14.9 3.1 0.49 11.0 1.7 2.5 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_7 PF13241.6 EGD92452.1 - 0.049 14.1 0.0 0.11 13.0 0.0 1.6 2 0 0 2 2 1 0 Putative NAD(P)-binding TrkA_N PF02254.18 EGD92452.1 - 0.15 12.3 0.2 0.29 11.4 0.2 1.5 1 0 0 1 1 1 0 TrkA-N domain ApbA PF02558.16 EGD92452.1 - 0.16 11.6 0.1 0.26 10.9 0.1 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA GIDA PF01134.22 EGD92452.1 - 0.22 10.5 2.5 0.44 9.6 1.1 1.9 2 0 0 2 2 2 0 Glucose inhibited division protein A Lycopene_cycl PF05834.12 EGD92452.1 - 0.57 9.2 3.5 0.32 10.0 0.8 1.9 3 0 0 3 3 3 0 Lycopene cyclase protein TPR_12 PF13424.6 EGD92453.1 - 5.8e-09 36.1 3.9 0.0015 18.7 0.5 3.5 2 1 2 4 4 4 3 Tetratricopeptide repeat TPR_14 PF13428.6 EGD92453.1 - 0.00069 20.2 5.8 1.6 9.7 0.3 4.6 4 1 0 4 4 4 1 Tetratricopeptide repeat TPR_10 PF13374.6 EGD92453.1 - 0.0037 17.1 2.3 28 4.8 0.0 4.3 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_2 PF07719.17 EGD92453.1 - 0.0041 17.1 0.6 0.67 10.2 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 EGD92453.1 - 0.0089 15.8 0.0 3.2 7.7 0.0 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 EGD92453.1 - 0.031 14.5 0.1 4 7.9 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat BTB_2 PF02214.22 EGD92454.1 - 3.4e-07 30.5 0.0 6.7e-07 29.6 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain BTB PF00651.31 EGD92454.1 - 5.4e-07 29.8 0.0 9.5e-07 29.0 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain I-set PF07679.16 EGD92454.1 - 0.057 13.5 0.1 0.14 12.3 0.1 1.6 1 0 0 1 1 1 0 Immunoglobulin I-set domain HLH PF00010.26 EGD92455.1 - 5.9e-12 45.4 1.2 1.1e-11 44.5 1.2 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain DASH_Dad4 PF08650.10 EGD92455.1 - 0.052 13.5 0.5 0.16 11.9 0.5 1.9 1 1 0 1 1 1 0 DASH complex subunit Dad4 pP_pnuc_1 PF18165.1 EGD92455.1 - 0.81 9.6 4.1 7.8 6.4 4.1 2.2 1 1 0 1 1 1 0 Predicted pPIWI-associating nuclease Mobilization_B PF17511.2 EGD92455.1 - 1.3 9.4 7.6 0.1 13.0 0.9 2.1 1 1 1 2 2 2 0 Mobilization protein B CN_hydrolase PF00795.22 EGD92458.1 - 2.2e-12 46.9 0.0 6e-12 45.4 0.0 1.7 2 0 0 2 2 2 1 Carbon-nitrogen hydrolase Clr5 PF14420.6 EGD92459.1 - 5.8e-14 52.1 0.0 1.2e-13 51.0 0.0 1.6 1 0 0 1 1 1 1 Clr5 domain SAC3_GANP PF03399.16 EGD92460.1 - 4.1e-105 351.4 4.7 4.1e-105 351.4 4.7 2.2 2 1 1 3 3 3 1 SAC3/GANP family CSN8_PSD8_EIF3K PF10075.9 EGD92460.1 - 4.7e-05 23.4 0.5 0.00016 21.6 0.5 1.9 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family HC2 PF07382.11 EGD92460.1 - 0.42 10.7 20.8 0.82 9.7 20.8 1.4 1 0 0 1 1 1 0 Histone H1-like nucleoprotein HC2 Zip PF02535.22 EGD92461.1 - 5.6e-52 177.0 3.8 6.9e-52 176.7 3.8 1.1 1 0 0 1 1 1 1 ZIP Zinc transporter 7TM_transglut PF14402.6 EGD92461.1 - 0.0045 16.5 0.1 0.0093 15.5 0.1 1.5 1 0 0 1 1 1 1 7 transmembrane helices usually fused to an inactive transglutaminase Ni_hydr_CYTB PF01292.20 EGD92461.1 - 3 7.4 12.1 0.042 13.5 3.1 2.3 2 1 0 2 2 2 0 Prokaryotic cytochrome b561 DUF2841 PF11001.8 EGD92462.1 - 9.1e-53 177.6 0.1 1.6e-52 176.8 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2841) CorA PF01544.18 EGD92462.1 - 0.021 14.2 0.2 0.032 13.6 0.2 1.2 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein ABC_membrane PF00664.23 EGD92467.1 - 6.3e-87 291.7 31.1 2.3e-46 158.7 12.5 2.5 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EGD92467.1 - 7.5e-52 175.5 0.0 1.9e-30 106.2 0.1 2.6 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EGD92467.1 - 4.3e-10 39.4 0.9 0.00021 20.8 0.1 4.0 2 2 2 4 4 4 2 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 EGD92467.1 - 3e-06 27.2 1.1 0.0014 18.6 0.1 2.6 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 EGD92467.1 - 4e-06 26.9 1.9 0.036 14.1 0.1 3.0 3 0 0 3 3 3 2 50S ribosome-binding GTPase AAA_16 PF13191.6 EGD92467.1 - 2.7e-05 24.6 0.8 0.027 14.8 0.7 2.5 2 0 0 2 2 2 2 AAA ATPase domain Dynamin_N PF00350.23 EGD92467.1 - 0.0022 18.1 0.7 0.19 11.8 0.0 2.7 2 0 0 2 2 2 1 Dynamin family AAA_29 PF13555.6 EGD92467.1 - 0.0036 17.0 0.7 1.8 8.4 0.1 2.8 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_30 PF13604.6 EGD92467.1 - 0.0051 16.6 0.3 3.4 7.4 0.0 3.0 2 1 0 2 2 2 1 AAA domain AAA_23 PF13476.6 EGD92467.1 - 0.0052 17.3 0.5 0.41 11.1 0.0 3.0 3 0 0 3 3 3 1 AAA domain Roc PF08477.13 EGD92467.1 - 0.012 15.8 3.4 17 5.7 0.0 4.3 4 0 0 4 4 4 0 Ras of Complex, Roc, domain of DAPkinase DUF87 PF01935.17 EGD92467.1 - 0.013 15.6 2.4 1.7 8.7 0.1 2.6 2 0 0 2 2 2 0 Helicase HerA, central domain RNA_helicase PF00910.22 EGD92467.1 - 0.018 15.4 0.0 1.7 9.0 0.0 2.8 2 0 0 2 2 2 0 RNA helicase AAA_21 PF13304.6 EGD92467.1 - 0.031 14.1 0.7 0.64 9.8 0.0 2.8 3 0 0 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 EGD92467.1 - 0.033 14.5 3.3 3.7 7.8 0.1 3.2 2 1 0 2 2 2 0 AAA domain DUP PF00674.18 EGD92467.1 - 0.048 13.8 0.7 0.36 11.0 0.7 2.6 1 0 0 1 1 1 0 DUP family DUF720 PF05302.11 EGD92467.1 - 0.1 12.5 0.1 0.3 10.9 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF720) IstB_IS21 PF01695.17 EGD92467.1 - 0.31 10.7 2.6 15 5.3 0.0 3.6 4 0 0 4 4 4 0 IstB-like ATP binding protein NACHT PF05729.12 EGD92467.1 - 0.45 10.4 5.0 6.4 6.7 0.1 3.2 3 0 0 3 3 3 0 NACHT domain bVLRF1 PF18826.1 EGD92468.1 - 1e-60 204.0 0.4 2.3e-60 202.8 0.4 1.7 1 0 0 1 1 1 1 bacteroidetes VLRF1 release factor Ank_5 PF13857.6 EGD92468.1 - 0.0001 22.5 0.0 0.00022 21.5 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.30 EGD92468.1 - 0.00089 19.6 0.1 0.0021 18.4 0.1 1.6 1 0 0 1 1 1 1 Ankyrin repeat Ank_3 PF13606.6 EGD92468.1 - 0.002 18.4 0.0 0.0055 17.1 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeat Ank_2 PF12796.7 EGD92468.1 - 0.0062 17.1 0.0 0.015 15.9 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) zf-C2H2_2 PF12756.7 EGD92468.1 - 0.077 13.3 0.1 0.16 12.3 0.1 1.5 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) Pkinase PF00069.25 EGD92470.1 - 7.8e-57 192.6 0.1 7.3e-53 179.6 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EGD92470.1 - 9.3e-27 93.9 0.0 2.7e-25 89.1 0.0 2.1 2 0 0 2 2 2 1 Protein tyrosine kinase FHA PF00498.26 EGD92470.1 - 1.2e-10 41.5 0.0 2.8e-10 40.4 0.0 1.7 1 0 0 1 1 1 1 FHA domain Pkinase_fungal PF17667.1 EGD92470.1 - 2.9e-06 26.3 0.1 1e-05 24.5 0.0 1.8 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 EGD92470.1 - 0.00027 20.4 0.0 0.0004 19.8 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 EGD92470.1 - 0.0072 16.3 0.0 0.017 15.1 0.0 1.7 1 1 0 1 1 1 1 Phosphotransferase enzyme family Yop-YscD_cpl PF16697.5 EGD92470.1 - 0.011 16.1 0.0 0.039 14.3 0.0 2.0 1 1 0 1 1 1 0 Inner membrane component of T3SS, cytoplasmic domain Kdo PF06293.14 EGD92470.1 - 0.055 12.8 0.0 0.11 11.9 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Myb_DNA-bind_6 PF13921.6 EGD92471.1 - 0.00079 19.6 0.0 0.0016 18.6 0.0 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 EGD92471.1 - 0.035 14.3 0.5 0.098 12.9 0.5 1.8 1 0 0 1 1 1 0 Myb-like DNA-binding domain SRP14 PF02290.15 EGD92471.1 - 0.12 12.7 0.1 0.2 12.0 0.1 1.3 1 0 0 1 1 1 0 Signal recognition particle 14kD protein DUF3431 PF11913.8 EGD92473.1 - 4.6e-60 203.1 0.0 6.3e-60 202.6 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3431) zf-CCCH PF00642.24 EGD92474.1 - 3.6e-08 33.1 2.9 6.8e-08 32.2 2.9 1.5 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-C3HC4_3 PF13920.6 EGD92474.1 - 1.2e-07 31.5 7.0 2.6e-07 30.4 7.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EGD92474.1 - 1.7e-06 27.8 10.5 2.9e-06 27.1 10.5 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EGD92474.1 - 2.7e-06 27.3 6.8 6.5e-06 26.1 6.8 1.7 1 1 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 EGD92474.1 - 5.2e-06 26.2 10.6 9.2e-06 25.4 10.6 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EGD92474.1 - 1.7e-05 24.6 11.8 3e-05 23.8 11.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EGD92474.1 - 2.4e-05 24.6 9.4 4.7e-05 23.6 9.4 1.5 1 0 0 1 1 1 1 Ring finger domain zf_CCCH_4 PF18345.1 EGD92474.1 - 7.3e-05 22.7 6.1 0.00014 21.8 6.1 1.5 1 0 0 1 1 1 1 Zinc finger domain zf-RING_10 PF16685.5 EGD92474.1 - 0.00051 20.1 4.5 0.0013 18.8 4.5 1.7 1 0 0 1 1 1 1 zinc RING finger of MSL2 zf-CCCH_4 PF18044.1 EGD92474.1 - 0.0024 17.6 3.0 0.0041 16.9 3.0 1.4 1 0 0 1 1 1 1 CCCH-type zinc finger zf-C3HC4_4 PF15227.6 EGD92474.1 - 0.021 15.0 8.0 0.045 13.9 8.0 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING Cript PF10235.9 EGD92474.1 - 0.026 15.1 1.0 0.12 13.0 1.0 2.1 1 0 0 1 1 1 0 Microtubule-associated protein CRIPT Prok-RING_4 PF14447.6 EGD92474.1 - 0.06 13.2 8.7 0.11 12.4 8.7 1.4 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-rbx1 PF12678.7 EGD92474.1 - 0.38 11.1 6.0 0.94 9.8 6.0 1.7 1 0 0 1 1 1 0 RING-H2 zinc finger domain DUF5427 PF10310.9 EGD92474.1 - 1.1 8.1 9.7 1.4 7.8 9.7 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5427) Mcp5_PH PF12814.7 EGD92475.1 - 4.5e-44 149.5 0.2 1.1e-43 148.3 0.2 1.7 1 0 0 1 1 1 1 Meiotic cell cortex C-terminal pleckstrin homology PH PF00169.29 EGD92475.1 - 9.9e-05 22.8 0.0 0.00021 21.7 0.0 1.5 1 0 0 1 1 1 1 PH domain Herpes_UL25 PF01499.16 EGD92475.1 - 8.3 4.8 17.8 0.15 10.5 5.5 3.0 2 1 1 3 3 3 0 Herpesvirus UL25 family Methyltransf_23 PF13489.6 EGD92476.1 - 9.8e-11 41.8 0.0 1.2e-10 41.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EGD92476.1 - 5.2e-06 27.1 0.0 8.3e-06 26.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EGD92476.1 - 4e-05 23.5 0.0 5.2e-05 23.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EGD92476.1 - 8.5e-05 23.1 0.0 0.00013 22.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EGD92476.1 - 0.066 13.9 0.0 0.12 13.1 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain DUF2439 PF10382.9 EGD92477.1 - 7.3e-25 87.1 0.0 1.3e-24 86.3 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2439) DUF4023 PF13215.6 EGD92477.1 - 0.15 12.1 0.3 0.15 12.1 0.3 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF4023) BAR PF03114.18 EGD92479.1 - 2.9e-13 50.0 0.3 4.2e-13 49.5 0.3 1.1 1 0 0 1 1 1 1 BAR domain SH3_1 PF00018.28 EGD92479.1 - 1.9e-12 46.6 0.1 3.8e-12 45.6 0.1 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EGD92479.1 - 4.6e-12 45.6 0.1 9.6e-12 44.6 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EGD92479.1 - 4.4e-09 35.9 0.1 9.7e-09 34.8 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain PIN_8 PF18476.1 EGD92479.1 - 0.11 12.4 0.1 0.11 12.4 0.1 1.8 3 0 0 3 3 3 0 PIN like domain U1snRNP70_N PF12220.8 EGD92479.1 - 3.5 8.3 9.3 4.9 7.9 1.2 2.8 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal TSC21 PF15217.6 EGD92480.1 - 0.1 12.5 0.1 0.28 11.1 0.1 1.7 2 0 0 2 2 2 0 TSC21 family RTC PF01137.21 EGD92482.1 - 4.8e-44 150.2 0.0 6.1e-43 146.6 0.0 2.1 1 1 0 1 1 1 1 RNA 3'-terminal phosphate cyclase Urocanase_C PF17392.2 EGD92482.1 - 0.12 11.9 0.0 0.2 11.1 0.0 1.3 1 0 0 1 1 1 0 Urocanase C-terminal domain DUF2786 PF10979.8 EGD92483.1 - 1.4e-15 56.9 0.7 1.4e-15 56.9 0.7 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF2786) Atrophin-1 PF03154.15 EGD92483.1 - 0.16 10.2 5.7 0.27 9.5 5.7 1.3 1 0 0 1 1 1 0 Atrophin-1 family CENP-Q PF13094.6 EGD92483.1 - 0.35 11.1 7.6 0.035 14.3 2.8 1.8 2 0 0 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit Exo_endo_phos PF03372.23 EGD92484.1 - 0.00016 21.2 0.0 0.00051 19.6 0.0 1.8 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family MIOX PF05153.15 EGD92485.1 - 1.4e-125 417.9 2.0 1.8e-125 417.5 2.0 1.1 1 0 0 1 1 1 1 Myo-inositol oxygenase DUF1796 PF08795.10 EGD92485.1 - 0.015 15.3 0.5 0.025 14.5 0.5 1.4 1 0 0 1 1 1 0 Putative papain-like cysteine peptidase (DUF1796) NOG1_N PF17835.1 EGD92485.1 - 0.037 14.0 3.2 0.2 11.6 0.1 2.7 2 1 0 2 2 2 0 NOG1 N-terminal helical domain HD PF01966.22 EGD92485.1 - 0.074 13.3 0.8 0.98 9.6 0.0 2.6 3 0 0 3 3 3 0 HD domain UBD PF16455.5 EGD92485.1 - 0.092 13.0 0.0 0.18 12.1 0.0 1.6 1 0 0 1 1 1 0 Ubiquitin-binding domain Cep57_CLD_2 PF14197.6 EGD92485.1 - 0.21 11.7 2.7 1.9 8.7 0.4 2.5 2 0 0 2 2 2 0 Centrosome localisation domain of PPC89 HNH_2 PF13391.6 EGD92487.1 - 7.3e-13 48.4 0.6 2.3e-12 46.9 0.2 2.1 2 0 0 2 2 2 1 HNH endonuclease JIP_LZII PF16471.5 EGD92487.1 - 0.11 12.7 0.6 1.8 8.8 0.2 2.3 2 0 0 2 2 2 0 JNK-interacting protein leucine zipper II Abhydrolase_1 PF00561.20 EGD92488.1 - 6.4e-48 163.6 0.0 2.3e-47 161.8 0.0 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EGD92488.1 - 0.0005 20.7 4.5 0.0013 19.4 4.5 1.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family Gly_transf_sug PF04488.15 EGD92490.1 - 7.3e-18 65.0 0.1 2.1e-17 63.5 0.1 1.7 2 0 0 2 2 2 1 Glycosyltransferase sugar-binding region containing DXD motif Caps_synth PF05704.12 EGD92490.1 - 0.0072 15.7 0.1 0.023 14.1 0.0 1.8 2 0 0 2 2 2 1 Capsular polysaccharide synthesis protein zf-C2H2_7 PF15269.6 EGD92490.1 - 0.23 11.6 0.4 0.69 10.0 0.4 1.8 1 0 0 1 1 1 0 Zinc-finger MFS_1 PF07690.16 EGD92491.1 - 2.5e-34 118.8 29.2 3.9e-34 118.1 29.2 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF3188 PF11384.8 EGD92491.1 - 0.87 9.3 5.4 0.6 9.9 1.1 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3188) Methyltransf_8 PF05148.15 EGD92492.1 - 0.26 11.1 0.0 0.36 10.6 0.0 1.2 1 0 0 1 1 1 0 Hypothetical methyltransferase THOC2_N PF16134.5 EGD92493.1 - 1.7e-241 803.3 0.2 6.1e-241 801.5 0.0 2.0 2 0 0 2 2 2 1 THO complex subunit 2 N-terminus Tho2 PF11262.8 EGD92493.1 - 1.6e-107 359.2 0.0 2.3e-107 358.7 0.0 1.3 1 0 0 1 1 1 1 Transcription factor/nuclear export subunit protein 2 Thoc2 PF11732.8 EGD92493.1 - 2.6e-29 101.1 0.4 7e-29 99.7 0.0 2.0 2 0 0 2 2 2 1 Transcription- and export-related complex subunit Menin PF05053.13 EGD92493.1 - 2.7 6.2 9.9 3.7 5.8 8.6 1.8 2 0 0 2 2 2 0 Menin APH PF01636.23 EGD92494.1 - 8e-09 35.8 0.1 1.2e-08 35.2 0.1 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EGD92494.1 - 0.00087 18.9 0.0 0.0013 18.3 0.0 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase EcKinase PF02958.20 EGD92494.1 - 0.12 11.7 0.1 0.18 11.1 0.1 1.2 1 0 0 1 1 1 0 Ecdysteroid kinase GFA PF04828.14 EGD92495.1 - 6.5e-18 64.9 0.0 1e-17 64.2 0.0 1.3 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme Vps5 PF09325.10 EGD92496.1 - 3.2e-11 43.2 2.3 6.5e-11 42.2 2.3 1.4 1 0 0 1 1 1 1 Vps5 C terminal like PX PF00787.24 EGD92496.1 - 1.2e-08 35.0 0.0 2.5e-08 33.9 0.0 1.5 1 0 0 1 1 1 1 PX domain GTP_EFTU PF00009.27 EGD92497.1 - 2e-55 187.4 0.0 3.7e-55 186.5 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_II PF14492.6 EGD92497.1 - 6.3e-25 87.1 0.0 1.5e-24 85.9 0.0 1.7 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.24 EGD92497.1 - 1.3e-16 60.4 0.0 1e-08 35.0 0.0 2.4 2 0 0 2 2 2 2 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 EGD92497.1 - 4.6e-06 26.9 0.0 1.3e-05 25.5 0.0 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 RF3_C PF16658.5 EGD92497.1 - 6.3e-05 22.8 0.0 0.00014 21.7 0.0 1.5 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain EFG_IV PF03764.18 EGD92497.1 - 0.0022 17.8 0.1 0.56 10.0 0.0 2.6 1 1 1 2 2 2 2 Elongation factor G, domain IV ArfGap PF01412.18 EGD92498.1 - 6.1e-31 106.9 0.0 9.5e-31 106.3 0.0 1.3 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf RRM_1 PF00076.22 EGD92499.1 - 2e-29 101.2 0.1 1.1e-14 54.0 0.0 3.2 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EGD92499.1 - 0.0014 18.2 0.0 0.35 10.5 0.0 3.0 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EGD92499.1 - 0.0022 18.1 0.0 0.15 12.2 0.0 2.6 2 1 0 2 2 2 1 RNA recognition motif PHM7_cyt PF14703.6 EGD92499.1 - 0.034 14.4 0.2 8.9 6.5 0.1 3.0 3 0 0 3 3 3 0 Cytosolic domain of 10TM putative phosphate transporter API5 PF05918.11 EGD92499.1 - 0.97 8.2 5.1 1.5 7.5 5.1 1.2 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) FRG2 PF15315.6 EGD92499.1 - 4.2 7.5 10.9 7.2 6.8 10.9 1.3 1 0 0 1 1 1 0 Facioscapulohumeral muscular dystrophy candidate 2 MARVEL PF01284.23 EGD92501.1 - 2.3e-06 27.7 3.6 3.7e-06 27.0 3.6 1.3 1 0 0 1 1 1 1 Membrane-associating domain DUF3246 PF11596.8 EGD92501.1 - 5.6 6.3 6.6 3.3 7.1 0.5 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3246) ATP-grasp_3 PF02655.14 EGD92502.1 - 1.9e-10 41.0 0.0 3.2e-10 40.3 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain GFO_IDH_MocA_C PF02894.17 EGD92503.1 - 6.4e-14 51.9 0.0 1e-13 51.3 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain GFO_IDH_MocA PF01408.22 EGD92503.1 - 0.0015 19.3 0.1 0.0032 18.3 0.1 1.5 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold HPP PF04982.13 EGD92506.1 - 3.3e-40 137.0 7.9 6e-40 136.2 7.9 1.4 1 0 0 1 1 1 1 HPP family DUF3377 PF11857.8 EGD92506.1 - 0.01 15.7 0.5 0.029 14.3 0.5 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) DUF599 PF04654.12 EGD92506.1 - 0.031 13.7 2.0 3.5 7.0 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function, DUF599 Yip1 PF04893.17 EGD92506.1 - 0.072 12.8 11.3 1.8 8.2 0.7 2.6 1 1 2 3 3 3 0 Yip1 domain DUF1772 PF08592.11 EGD92506.1 - 5.5 7.3 7.3 2.3 8.5 0.6 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF1772) MFS_1 PF07690.16 EGD92507.1 - 3.4e-37 128.2 55.8 1e-36 126.6 54.0 2.7 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EGD92507.1 - 6.9e-16 58.1 9.9 6.9e-16 58.1 9.9 2.9 3 1 0 3 3 3 1 Sugar (and other) transporter TRI12 PF06609.13 EGD92507.1 - 1e-14 53.9 15.2 1.7e-14 53.2 15.2 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) DUF3522 PF12036.8 EGD92507.1 - 0.93 9.7 6.0 0.11 12.8 0.5 2.3 3 1 0 3 3 3 0 Protein of unknown function (DUF3522) DUF4267 PF14087.6 EGD92508.1 - 1.3e-24 86.4 2.0 1.5e-24 86.3 2.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4267) SLC3A2_N PF16028.5 EGD92509.1 - 0.053 13.1 0.5 0.053 13.1 0.5 2.4 3 0 0 3 3 3 0 Solute carrier family 3 member 2 N-terminus p450 PF00067.22 EGD92510.1 - 1e-20 74.0 0.0 6.9e-19 67.9 0.0 2.1 1 1 0 1 1 1 1 Cytochrome P450 DEP PF00610.21 EGD92510.1 - 0.074 13.1 0.0 0.18 11.9 0.0 1.6 1 0 0 1 1 1 0 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) ABC_tran PF00005.27 EGD92511.1 - 3.6e-35 121.5 0.0 2.6e-23 83.0 0.0 2.6 2 0 0 2 2 2 2 ABC transporter ABC_tran_Xtn PF12848.7 EGD92511.1 - 1.8e-21 76.0 3.2 1.8e-21 76.0 3.2 2.3 2 0 0 2 2 2 1 ABC transporter AAA_21 PF13304.6 EGD92511.1 - 6.3e-14 52.5 0.6 0.00091 19.1 0.0 3.3 2 1 1 3 3 3 3 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EGD92511.1 - 2.1e-08 33.9 0.1 0.00084 18.8 0.1 3.3 2 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 EGD92511.1 - 0.00064 20.3 0.8 0.043 14.3 0.0 2.8 3 0 0 3 3 3 1 AAA domain AAA_29 PF13555.6 EGD92511.1 - 0.00085 19.0 0.1 0.0025 17.5 0.0 1.8 2 0 0 2 2 2 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EGD92511.1 - 0.002 18.0 0.3 0.0052 16.7 0.0 1.8 2 0 0 2 2 2 1 RsgA GTPase MMR_HSR1 PF01926.23 EGD92511.1 - 0.0039 17.2 0.0 0.012 15.6 0.0 1.9 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_15 PF13175.6 EGD92511.1 - 0.0064 16.2 0.2 0.019 14.7 0.0 1.9 2 0 0 2 2 2 1 AAA ATPase domain AAA_16 PF13191.6 EGD92511.1 - 0.01 16.2 0.0 0.025 15.0 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain AAA_18 PF13238.6 EGD92511.1 - 0.017 15.6 0.1 0.069 13.7 0.0 2.1 2 0 0 2 2 2 0 AAA domain GST_C_3 PF14497.6 EGD92511.1 - 0.032 14.4 0.2 0.075 13.2 0.2 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain AAA_22 PF13401.6 EGD92511.1 - 0.053 13.8 0.0 0.15 12.3 0.0 1.8 1 0 0 1 1 1 0 AAA domain Dynamin_N PF00350.23 EGD92511.1 - 0.063 13.3 1.6 0.6 10.2 0.0 2.6 2 1 0 2 2 2 0 Dynamin family AAA_33 PF13671.6 EGD92511.1 - 0.18 11.9 0.1 0.18 11.9 0.1 2.4 3 0 0 3 3 3 0 AAA domain Cyclin_C_2 PF16899.5 EGD92512.1 - 2.6e-36 124.1 0.0 2.2e-32 111.5 0.0 2.4 2 0 0 2 2 2 2 Cyclin C-terminal domain Cyclin_N PF00134.23 EGD92512.1 - 0.00032 20.5 0.0 0.00074 19.3 0.0 1.6 1 0 0 1 1 1 1 Cyclin, N-terminal domain UQ_con PF00179.26 EGD92513.1 - 1.8e-43 147.6 0.0 2.2e-43 147.2 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UBA_3 PF09288.10 EGD92513.1 - 3.9e-06 26.6 0.0 8.3e-06 25.5 0.0 1.5 1 0 0 1 1 1 1 Fungal ubiquitin-associated domain Prok-E2_B PF14461.6 EGD92513.1 - 5.6e-05 22.9 0.0 0.00011 21.9 0.0 1.4 2 0 0 2 2 2 1 Prokaryotic E2 family B RWD PF05773.22 EGD92513.1 - 0.06 13.6 0.0 0.094 13.0 0.0 1.4 1 0 0 1 1 1 0 RWD domain APH PF01636.23 EGD92514.1 - 1.4e-13 51.4 0.0 1.4e-12 48.1 0.0 2.6 3 1 0 3 3 3 1 Phosphotransferase enzyme family Pkinase PF00069.25 EGD92514.1 - 0.062 12.6 0.0 0.3 10.4 0.0 1.9 2 0 0 2 2 2 0 Protein kinase domain DUF1679 PF07914.11 EGD92514.1 - 0.13 11.1 0.1 2.9 6.6 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1679) AAA PF00004.29 EGD92515.1 - 1.1e-40 139.2 0.0 1.9e-40 138.3 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EGD92515.1 - 1.4e-09 37.6 0.5 2.9e-09 36.6 0.5 1.5 1 0 0 1 1 1 1 AAA+ lid domain Prot_ATP_ID_OB PF16450.5 EGD92515.1 - 1.8e-09 37.4 0.1 3.2e-09 36.6 0.1 1.5 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_22 PF13401.6 EGD92515.1 - 1e-05 25.9 0.4 0.078 13.3 0.2 2.7 1 1 1 2 2 2 2 AAA domain AAA_2 PF07724.14 EGD92515.1 - 1.6e-05 25.1 0.0 3.2e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) DUF815 PF05673.13 EGD92515.1 - 6.6e-05 22.2 0.0 0.00011 21.4 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_5 PF07728.14 EGD92515.1 - 0.00013 22.0 0.0 0.00035 20.6 0.0 1.8 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 EGD92515.1 - 0.0013 18.5 0.0 0.0026 17.5 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EGD92515.1 - 0.0018 18.7 0.5 0.019 15.3 0.4 2.2 1 1 0 1 1 1 1 AAA ATPase domain AAA_28 PF13521.6 EGD92515.1 - 0.0027 18.0 0.2 0.0075 16.5 0.0 1.9 2 0 0 2 2 1 1 AAA domain IstB_IS21 PF01695.17 EGD92515.1 - 0.017 14.8 0.0 0.037 13.8 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein ATPase PF06745.13 EGD92515.1 - 0.03 13.7 0.4 0.39 10.0 0.2 2.2 1 1 0 2 2 2 0 KaiC TIP49 PF06068.13 EGD92515.1 - 0.034 13.4 1.5 0.065 12.4 0.1 1.9 2 1 0 2 2 2 0 TIP49 P-loop domain AAA_18 PF13238.6 EGD92515.1 - 0.038 14.5 0.0 0.086 13.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_3 PF07726.11 EGD92515.1 - 0.056 13.3 0.0 0.12 12.2 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 EGD92515.1 - 0.068 13.1 0.6 1.6 8.7 0.2 2.7 2 1 1 3 3 3 0 NACHT domain AAA_33 PF13671.6 EGD92515.1 - 0.1 12.8 0.0 0.21 11.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 EGD92515.1 - 0.12 12.1 3.6 0.46 10.2 0.4 2.5 2 1 0 2 2 2 0 AAA domain AAA_14 PF13173.6 EGD92515.1 - 0.12 12.4 0.0 0.24 11.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EGD92515.1 - 0.12 12.8 0.0 0.26 11.7 0.0 1.6 1 0 0 1 1 1 0 RNA helicase PhoH PF02562.16 EGD92515.1 - 0.12 11.8 1.1 1.1 8.7 0.1 2.1 2 0 0 2 2 2 0 PhoH-like protein DUF2075 PF09848.9 EGD92515.1 - 0.14 11.4 0.0 0.22 10.7 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_19 PF13245.6 EGD92515.1 - 0.16 12.3 0.4 0.42 10.9 0.4 1.7 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 EGD92515.1 - 0.16 11.3 0.1 0.33 10.3 0.1 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Prot_ATP_OB_N PF17758.1 EGD92515.1 - 0.21 11.3 0.7 0.98 9.1 0.0 2.3 2 0 0 2 2 2 0 Proteasomal ATPase OB N-terminal domain Zeta_toxin PF06414.12 EGD92515.1 - 0.21 10.8 0.1 0.21 10.8 0.1 1.9 2 0 0 2 2 1 0 Zeta toxin WD40 PF00400.32 EGD92516.1 - 1.4e-12 47.9 11.3 0.0097 16.7 0.3 5.7 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EGD92516.1 - 0.0051 17.1 0.0 2.6 8.4 0.0 3.8 3 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EGD92516.1 - 0.15 11.9 0.0 2.2 8.1 0.0 2.6 2 1 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A Mg_trans_NIPA PF05653.14 EGD92517.1 - 3.4e-62 210.2 13.8 7.9e-60 202.5 10.5 2.1 2 0 0 2 2 2 2 Magnesium transporter NIPA EamA PF00892.20 EGD92517.1 - 0.00028 21.1 1.3 0.00028 21.1 1.3 3.7 3 1 0 3 3 3 1 EamA-like transporter family SLC35F PF06027.12 EGD92517.1 - 0.00056 19.5 4.5 0.00085 18.9 3.9 1.5 1 1 0 1 1 1 1 Solute carrier family 35 Trp_oprn_chp PF09534.10 EGD92517.1 - 0.0047 16.7 0.3 0.94 9.2 0.4 2.7 2 0 0 2 2 2 1 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Ctr PF04145.15 EGD92517.1 - 0.13 12.9 0.3 16 6.1 0.1 3.2 2 2 0 2 2 2 0 Ctr copper transporter family DoxX_2 PF13564.6 EGD92517.1 - 0.17 12.0 6.1 2.2 8.5 0.6 2.5 2 0 0 2 2 2 0 DoxX-like family DUF2198 PF09964.9 EGD92517.1 - 1 9.4 5.8 0.28 11.3 1.0 2.3 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2198) TssN PF17555.2 EGD92517.1 - 6.9 6.0 9.0 11 5.3 9.0 1.3 1 0 0 1 1 1 0 Type VI secretion system, TssN BaxI_1 PF12811.7 EGD92517.1 - 7.3 6.1 12.5 1.1e+02 2.2 12.5 2.4 1 1 0 1 1 1 0 Bax inhibitor 1 like ABC_tran_CTD PF16326.5 EGD92518.1 - 0.069 13.4 3.6 0.33 11.2 3.6 2.2 1 0 0 1 1 1 0 ABC transporter C-terminal domain bZIP_1 PF00170.21 EGD92518.1 - 1.8 8.7 10.5 4.5 7.4 5.9 2.6 2 0 0 2 2 2 0 bZIP transcription factor FlaC_arch PF05377.11 EGD92518.1 - 2.5 8.6 6.5 1.4 9.4 2.4 2.4 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) VASt PF16016.5 EGD92519.1 - 3.4e-34 118.5 0.0 6e-34 117.7 0.0 1.4 1 0 0 1 1 1 1 VAD1 Analog of StAR-related lipid transfer domain GRAM PF02893.20 EGD92519.1 - 3.8e-21 75.1 0.0 7e-21 74.2 0.0 1.5 1 0 0 1 1 1 1 GRAM domain Axin_b-cat_bind PF08833.10 EGD92519.1 - 0.052 13.6 0.2 0.052 13.6 0.2 2.9 4 0 0 4 4 4 0 Axin beta-catenin binding domain TPR_2 PF07719.17 EGD92520.1 - 5.8e-06 26.0 7.7 0.011 15.7 0.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 EGD92520.1 - 2.9e-05 23.7 3.2 0.47 10.4 0.0 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 EGD92520.1 - 0.00069 19.9 5.1 0.098 13.0 0.0 3.2 2 1 1 3 3 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 EGD92520.1 - 0.0066 16.6 3.8 0.75 10.2 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 EGD92520.1 - 0.04 14.4 2.9 0.45 11.1 0.0 2.7 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.6 EGD92520.1 - 0.06 13.4 3.2 6.9 6.9 0.0 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EGD92520.1 - 0.068 13.4 0.3 0.3 11.3 0.3 2.1 1 1 1 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_16 PF13432.6 EGD92520.1 - 0.59 10.8 4.8 1.6e+02 3.0 5.7 3.0 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_10 PF13374.6 EGD92520.1 - 1.2 9.1 9.1 17 5.4 0.0 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat Asp PF00026.23 EGD92521.1 - 6.2e-28 98.1 1.2 8e-28 97.8 1.2 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EGD92521.1 - 3.8e-05 24.0 0.3 0.038 14.2 0.0 2.2 1 1 1 2 2 2 2 Xylanase inhibitor N-terminal Cu_amine_oxid PF01179.20 EGD92522.1 - 5.8e-115 384.5 1.1 7.7e-115 384.1 1.1 1.1 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain Cu_amine_oxidN3 PF02728.16 EGD92522.1 - 2.5e-18 66.4 0.1 5.3e-18 65.3 0.1 1.6 1 0 0 1 1 1 1 Copper amine oxidase, N3 domain Cu_amine_oxidN2 PF02727.16 EGD92522.1 - 7.9e-15 54.9 0.0 1.5e-14 53.9 0.0 1.5 1 0 0 1 1 1 1 Copper amine oxidase, N2 domain CAF1 PF04857.20 EGD92523.1 - 1.7e-24 86.6 0.0 3.3e-11 42.9 0.0 2.8 3 0 0 3 3 3 2 CAF1 family ribonuclease Siva PF05458.12 EGD92523.1 - 0.18 11.4 0.7 21 4.8 1.4 2.3 2 0 0 2 2 2 0 Cd27 binding protein (Siva) ANAPC_CDC26 PF10471.9 EGD92523.1 - 0.47 11.3 12.6 3.9 8.4 0.2 2.5 2 0 0 2 2 2 0 Anaphase-promoting complex APC subunit CDC26 NDUF_B12 PF08122.12 EGD92524.1 - 1e-10 41.5 6.0 3e-10 40.0 3.2 2.1 1 1 1 2 2 2 2 NADH-ubiquinone oxidoreductase B12 subunit family WD40 PF00400.32 EGD92525.1 - 1.4e-19 70.0 6.8 0.0037 18.1 0.0 8.4 8 1 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EGD92525.1 - 8.2e-07 29.2 0.0 0.0011 19.2 0.0 3.7 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EGD92525.1 - 0.031 13.3 0.3 0.28 10.1 0.1 2.5 3 1 1 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein RAB3GAP2_N PF14655.6 EGD92525.1 - 0.08 12.2 0.0 0.17 11.1 0.0 1.6 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus AMP-binding PF00501.28 EGD92526.1 - 1.1e-80 271.3 0.0 1.5e-80 270.9 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EGD92526.1 - 3.1e-14 53.7 0.4 7.8e-14 52.4 0.4 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain 2OG-FeII_Oxy_2 PF13532.6 EGD92527.1 - 4.7e-29 102.0 0.0 1e-28 100.9 0.0 1.5 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily CNH PF00780.22 EGD92528.1 - 3e-65 220.6 0.0 4.7e-65 219.9 0.0 1.2 1 0 0 1 1 1 1 CNH domain RhoGEF PF00621.20 EGD92528.1 - 8.3e-34 117.4 1.4 1.6e-33 116.5 1.4 1.5 1 0 0 1 1 1 1 RhoGEF domain DNA_primase_S PF01896.19 EGD92528.1 - 1.3e-28 100.3 0.0 8.9e-28 97.5 0.0 2.2 2 0 0 2 2 2 1 DNA primase small subunit PH_5 PF15405.6 EGD92528.1 - 1.4e-14 54.3 0.0 5.1e-14 52.5 0.0 2.1 1 0 0 1 1 1 1 Pleckstrin homology domain PH PF00169.29 EGD92528.1 - 0.0043 17.5 0.0 0.016 15.7 0.0 2.0 2 0 0 2 2 2 1 PH domain PH_16 PF17838.1 EGD92528.1 - 0.006 16.4 0.1 3.7 7.4 0.0 2.4 2 0 0 2 2 2 2 PH domain PH_13 PF16652.5 EGD92528.1 - 0.14 12.0 0.0 2 8.2 0.0 2.6 2 0 0 2 2 2 0 Pleckstrin homology domain RabGAP-TBC PF00566.18 EGD92529.1 - 6.9e-47 159.9 0.0 1.1e-46 159.2 0.0 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain EF-hand_6 PF13405.6 EGD92529.1 - 9.5e-07 28.3 2.9 0.0099 15.8 0.3 3.3 3 0 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.32 EGD92529.1 - 1.6e-05 24.1 1.0 0.1 12.2 0.0 2.9 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 EGD92529.1 - 0.00089 19.7 1.1 0.013 15.9 0.1 3.1 1 1 2 3 3 3 3 EF-hand domain pair GRAM PF02893.20 EGD92529.1 - 0.002 18.0 0.0 0.004 17.0 0.0 1.5 1 0 0 1 1 1 1 GRAM domain DUF4611 PF15387.6 EGD92529.1 - 1.8 8.8 11.9 2.8 8.2 1.3 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4611) TssO PF17561.2 EGD92531.1 - 0.069 13.3 0.4 0.085 13.0 0.4 1.1 1 0 0 1 1 1 0 Type VI secretion system, TssO HMMR_N PF15905.5 EGD92532.1 - 0.00069 19.2 7.3 0.00069 19.2 7.3 2.6 2 0 0 2 2 2 1 Hyaluronan mediated motility receptor N-terminal XkdW PF09636.10 EGD92532.1 - 0.4 10.8 3.7 1.1 9.4 0.2 3.1 3 0 0 3 3 3 0 XkdW protein CREPT PF16566.5 EGD92532.1 - 2 8.6 12.6 0.21 11.8 3.6 2.6 1 1 0 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour HAUS5 PF14817.6 EGD92532.1 - 5.3 5.7 25.5 0.98 8.1 8.3 2.5 2 1 1 3 3 3 0 HAUS augmin-like complex subunit 5 AAA_13 PF13166.6 EGD92532.1 - 7.4 5.1 13.3 23 3.5 13.5 1.7 1 1 0 1 1 1 0 AAA domain DUF1640 PF07798.11 EGD92532.1 - 7.8 6.5 13.8 1.4e+02 2.4 13.8 2.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1640) Cnn_1N PF07989.11 EGD92532.1 - 8.2 6.7 9.2 4.3 7.6 1.5 3.3 2 1 1 3 3 3 0 Centrosomin N-terminal motif 1 Spc7 PF08317.11 EGD92532.1 - 9.8 5.0 18.4 1 8.2 8.1 2.6 1 1 1 2 2 2 0 Spc7 kinetochore protein adh_short_C2 PF13561.6 EGD92533.1 - 2.6e-35 122.1 7.0 1.1e-34 120.1 7.0 1.7 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EGD92533.1 - 4.1e-28 98.2 3.3 6.8e-28 97.5 3.3 1.3 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EGD92533.1 - 2.1e-06 27.8 2.1 1.1e-05 25.4 2.1 2.0 1 1 0 1 1 1 1 KR domain DUF1772 PF08592.11 EGD92534.1 - 0.00049 20.4 1.7 0.0038 17.5 1.7 2.0 1 1 0 1 1 1 1 Domain of unknown function (DUF1772) DUF401 PF04165.12 EGD92534.1 - 0.18 11.1 1.7 0.23 10.7 1.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF401) SAP PF02037.27 EGD92535.1 - 3.2e-09 36.3 0.1 6.1e-09 35.4 0.1 1.5 1 0 0 1 1 1 1 SAP domain RSB_motif PF16294.5 EGD92535.1 - 3.5e-07 30.4 0.0 3.5e-07 30.4 0.0 3.7 2 1 0 3 3 3 1 RNSP1-SAP18 binding (RSB) motif Pinin_SDK_memA PF04696.13 EGD92535.1 - 0.33 11.0 0.0 0.33 11.0 0.0 3.2 2 1 1 3 3 3 0 pinin/SDK/memA/ protein conserved region MAJIN PF15077.6 EGD92535.1 - 2.5 7.8 8.8 4.4 7.0 8.8 1.4 1 0 0 1 1 1 0 Membrane-anchored junction protein JAB PF01398.21 EGD92536.1 - 1.4e-11 44.4 0.4 2.7e-11 43.5 0.0 1.6 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.6 EGD92536.1 - 4.7e-11 43.1 0.8 1.3e-10 41.7 0.8 1.8 1 1 0 1 1 1 1 Maintenance of mitochondrial structure and function DUF4718 PF15842.5 EGD92536.1 - 0.16 11.8 0.9 0.31 10.8 0.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4718) RNA_pol_3_Rpc31 PF11705.8 EGD92538.1 - 4.7e-64 216.7 12.9 6e-64 216.4 12.9 1.0 1 0 0 1 1 1 1 DNA-directed RNA polymerase III subunit Rpc31 TFIIA PF03153.13 EGD92538.1 - 0.0082 16.2 3.2 0.0081 16.2 3.2 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Flavodoxin_1 PF00258.25 EGD92540.1 - 4.5e-31 108.0 0.0 2.1e-30 105.8 0.0 2.0 2 0 0 2 2 2 1 Flavodoxin FAD_binding_1 PF00667.20 EGD92540.1 - 1.7e-30 106.2 0.0 2.6e-30 105.7 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain NAD_binding_1 PF00175.21 EGD92540.1 - 9.8e-09 35.8 0.2 4.1e-06 27.4 0.2 2.6 1 1 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 EGD92540.1 - 0.12 12.8 0.0 0.27 11.6 0.0 1.6 1 0 0 1 1 1 0 Oxidoreductase FAD-binding domain Flavodoxin_3 PF12641.7 EGD92540.1 - 0.2 11.3 0.0 1.3 8.7 0.0 2.0 2 0 0 2 2 2 0 Flavodoxin domain ETF PF01012.21 EGD92541.1 - 8.8e-41 139.8 0.3 1.1e-40 139.5 0.3 1.1 1 0 0 1 1 1 1 Electron transfer flavoprotein domain Ysc84 PF04366.12 EGD92542.1 - 1.7e-45 153.9 0.0 3.1e-45 153.1 0.0 1.4 1 0 0 1 1 1 1 Las17-binding protein actin regulator Antimicrobial10 PF08105.11 EGD92542.1 - 0.024 14.7 0.2 1 9.5 0.2 2.5 2 0 0 2 2 2 0 Metchnikowin family PARP PF00644.20 EGD92543.1 - 1.3e-59 201.1 0.0 1.3e-59 201.1 0.0 3.4 3 1 1 4 4 4 1 Poly(ADP-ribose) polymerase catalytic domain PARP_reg PF02877.14 EGD92543.1 - 2.1e-42 144.4 0.1 3.8e-42 143.6 0.1 1.4 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase, regulatory domain WGR PF05406.15 EGD92543.1 - 5.1e-24 84.1 0.6 5.1e-24 84.1 0.6 2.3 3 0 0 3 3 3 1 WGR domain BRCT PF00533.26 EGD92543.1 - 1.8e-09 37.8 0.0 6.4e-09 36.1 0.0 1.9 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 EGD92543.1 - 1.6e-07 31.2 0.1 3.4e-07 30.1 0.1 1.6 1 0 0 1 1 1 1 twin BRCT domain BRCT_2 PF16589.5 EGD92543.1 - 1.6e-05 25.2 0.0 3.7e-05 24.1 0.0 1.6 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain GREB1 PF15782.5 EGD92543.1 - 4 4.4 7.6 6.6 3.7 7.6 1.3 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Acetyltransf_3 PF13302.7 EGD92544.1 - 4.1e-09 37.2 0.0 5.5e-09 36.8 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EGD92544.1 - 0.0063 16.7 0.0 0.11 12.8 0.0 2.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Peptidase_S10 PF00450.22 EGD92545.1 - 4.2e-84 283.4 4.5 8.8e-84 282.3 4.5 1.5 1 1 0 1 1 1 1 Serine carboxypeptidase Spem1 PF15670.5 EGD92546.1 - 0.0091 15.6 1.9 0.0098 15.5 1.9 1.0 1 0 0 1 1 1 1 Spermatid maturation protein 1 Gyro_capsid PF04162.12 EGD92546.1 - 1.2 7.6 8.1 1.3 7.4 8.1 1.1 1 0 0 1 1 1 0 Gyrovirus capsid protein (VP1) GATase PF00117.28 EGD92547.1 - 1e-47 162.4 0.0 4.7e-47 160.2 0.0 1.9 2 0 0 2 2 2 1 Glutamine amidotransferase class-I CPSase_sm_chain PF00988.22 EGD92547.1 - 2.5e-44 150.2 0.0 1.3e-43 147.9 0.0 2.0 2 0 0 2 2 2 1 Carbamoyl-phosphate synthase small chain, CPSase domain Leader_CPA1 PF08252.11 EGD92547.1 - 3.4e-11 42.3 0.0 6.4e-11 41.4 0.0 1.5 1 0 0 1 1 1 1 arg-2/CPA1 leader peptide Peptidase_C26 PF07722.13 EGD92547.1 - 3.9e-05 23.5 0.3 0.0013 18.6 0.3 2.4 1 1 0 1 1 1 1 Peptidase C26 Imm9 PF15587.6 EGD92547.1 - 0.014 15.1 0.0 0.026 14.2 0.0 1.3 1 0 0 1 1 1 0 Immunity protein 9 DJ-1_PfpI PF01965.24 EGD92547.1 - 0.051 13.4 0.0 0.087 12.6 0.0 1.3 1 0 0 1 1 1 0 DJ-1/PfpI family RNA_pol_I_A49 PF06870.12 EGD92548.1 - 2e-69 234.3 0.2 2.4e-69 234.1 0.2 1.1 1 0 0 1 1 1 1 A49-like RNA polymerase I associated factor Aminotran_1_2 PF00155.21 EGD92549.1 - 7.7e-86 288.5 0.0 1.4e-85 287.7 0.0 1.4 2 0 0 2 2 2 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 EGD92549.1 - 2.4e-06 26.3 0.0 4.1e-06 25.6 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 EGD92549.1 - 1.4e-05 24.6 0.1 2.4e-05 23.8 0.1 1.3 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_5 PF00266.19 EGD92549.1 - 0.0011 18.0 0.0 0.0023 16.9 0.0 1.5 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 EGD92549.1 - 0.023 14.0 0.5 0.071 12.4 0.5 1.6 1 1 0 1 1 1 0 Beta-eliminating lyase NitrOD2 PF18550.1 EGD92549.1 - 0.09 12.9 0.0 0.23 11.6 0.0 1.6 1 0 0 1 1 1 0 Nitrososphaera output domain 2 p450 PF00067.22 EGD92550.1 - 8.3e-20 71.0 0.0 1.1e-19 70.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 CDI PF02234.19 EGD92550.1 - 0.013 15.7 0.5 0.034 14.4 0.5 1.6 1 0 0 1 1 1 0 Cyclin-dependent kinase inhibitor p450 PF00067.22 EGD92551.1 - 8.1e-66 222.6 0.0 1.1e-65 222.2 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Stirrup PF09061.6 EGD92551.1 - 0.097 12.9 0.3 28 5.0 0.1 3.2 3 0 0 3 3 3 0 Stirrup Vps54 PF07928.12 EGD92552.1 - 6.2e-26 91.4 0.0 2e-25 89.7 0.0 1.9 1 0 0 1 1 1 1 Vps54-like protein DUF2451 PF10474.9 EGD92552.1 - 6.3e-06 26.1 0.0 1.5e-05 24.9 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function C-terminus (DUF2451) SNF2_N PF00176.23 EGD92553.1 - 7.7e-71 238.6 0.6 2e-70 237.3 0.6 1.7 1 0 0 1 1 1 1 SNF2 family N-terminal domain Bromodomain PF00439.25 EGD92553.1 - 1.2e-25 89.4 0.4 1.4e-24 85.9 0.7 2.4 2 0 0 2 2 2 1 Bromodomain Helicase_C PF00271.31 EGD92553.1 - 1.1e-19 70.8 0.2 3.4e-18 66.0 0.0 3.3 3 0 0 3 3 3 1 Helicase conserved C-terminal domain HSA PF07529.13 EGD92553.1 - 6.4e-19 68.1 10.7 6.4e-19 68.1 10.7 3.3 4 0 0 4 4 4 1 HSA QLQ PF08880.11 EGD92553.1 - 2.5e-13 49.5 4.8 2.5e-13 49.5 4.8 2.8 2 0 0 2 2 2 1 QLQ SnAC PF14619.6 EGD92553.1 - 2.6e-13 50.4 0.1 2.6e-13 50.4 0.1 3.6 4 0 0 4 4 4 1 Snf2-ATP coupling, chromatin remodelling complex ResIII PF04851.15 EGD92553.1 - 2.4e-09 37.4 0.4 1.1e-08 35.2 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit BAR PF03114.18 EGD92554.1 - 1.3e-45 155.9 7.6 1.6e-45 155.6 7.6 1.1 1 0 0 1 1 1 1 BAR domain BAR_2 PF10455.9 EGD92554.1 - 2.7e-08 33.3 3.9 3.5e-08 32.9 3.9 1.1 1 0 0 1 1 1 1 Bin/amphiphysin/Rvs domain for vesicular trafficking AAA_23 PF13476.6 EGD92554.1 - 0.29 11.6 3.5 0.45 11.0 3.5 1.4 1 0 0 1 1 1 0 AAA domain APG6_N PF17675.1 EGD92554.1 - 0.88 10.1 11.8 1.4 9.5 9.2 2.2 2 0 0 2 2 2 0 Apg6 coiled-coil region TMPIT PF07851.13 EGD92554.1 - 4.5 6.4 5.4 7.7 5.7 5.4 1.3 1 0 0 1 1 1 0 TMPIT-like protein Ada_Zn_binding PF02805.16 EGD92556.1 - 2.2e-29 101.3 4.3 4.1e-29 100.4 4.3 1.5 1 0 0 1 1 1 1 Metal binding domain of Ada HTH_AraC PF00165.23 EGD92556.1 - 3e-07 30.4 0.0 7.6e-07 29.1 0.0 1.7 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix proteins, AraC family HTH_18 PF12833.7 EGD92556.1 - 0.00037 20.7 0.0 0.00083 19.6 0.0 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain Ribosomal_L2_C PF03947.18 EGD92557.1 - 1.6e-41 141.4 5.9 2.8e-41 140.6 5.9 1.3 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 EGD92557.1 - 3.8e-13 49.2 0.1 9.6e-13 47.9 0.1 1.7 1 0 0 1 1 1 1 Ribosomal Proteins L2, RNA binding domain WHIM1 PF15612.6 EGD92558.1 - 7.7e-08 31.7 0.0 1.7e-07 30.6 0.0 1.5 1 0 0 1 1 1 1 WSTF, HB1, Itc1p, MBD9 motif 1 DUF1770 PF08589.10 EGD92559.1 - 1.2e-17 64.7 0.0 1.6e-17 64.2 0.0 1.2 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1770) PfkB PF00294.24 EGD92560.1 - 7e-67 225.9 0.1 8.5e-67 225.6 0.1 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Phos_pyr_kin PF08543.12 EGD92560.1 - 2.4e-05 23.8 0.0 4.2e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase PS_pyruv_trans PF04230.13 EGD92560.1 - 0.0035 17.3 0.0 0.0047 16.9 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide pyruvyl transferase DUF5450 PF17529.2 EGD92560.1 - 0.05 13.7 0.0 0.09 12.9 0.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5450) CbiK PF06180.11 EGD92560.1 - 0.16 11.2 0.0 0.26 10.6 0.0 1.3 1 0 0 1 1 1 0 Cobalt chelatase (CbiK) EST1_DNA_bind PF10373.9 EGD92561.1 - 3.7e-58 197.2 3.7 5.6e-58 196.6 3.7 1.3 1 0 0 1 1 1 1 Est1 DNA/RNA binding domain EST1 PF10374.9 EGD92561.1 - 5.9e-23 82.0 0.4 2.2e-22 80.2 0.1 2.1 3 0 0 3 3 3 1 Telomerase activating protein Est1 FWWh PF14922.6 EGD92561.1 - 0.089 12.7 0.1 0.31 10.9 0.1 2.0 1 0 0 1 1 1 0 Protein of unknown function Acyl-CoA_dh_1 PF00441.24 EGD92562.1 - 2.5e-31 108.9 2.2 4.1e-31 108.2 2.2 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 EGD92562.1 - 2.4e-19 69.3 0.0 4.3e-19 68.5 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 EGD92562.1 - 4e-14 53.2 0.3 1e-13 51.9 0.1 1.8 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 EGD92562.1 - 5.8e-14 52.5 5.9 1e-13 51.7 5.9 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain IGPD PF00475.18 EGD92563.1 - 2.3e-57 193.4 1.3 3.3e-57 192.9 1.3 1.2 1 0 0 1 1 1 1 Imidazoleglycerol-phosphate dehydratase Spo12 PF05032.12 EGD92564.1 - 2.9e-14 52.7 0.4 7e-14 51.4 0.4 1.7 1 0 0 1 1 1 1 Spo12 family Sad1_UNC PF07738.13 EGD92565.1 - 3.3e-31 108.0 0.0 5.8e-31 107.2 0.0 1.4 1 0 0 1 1 1 1 Sad1 / UNC-like C-terminal KRAP_IP3R_bind PF14722.6 EGD92565.1 - 0.0079 15.9 0.8 0.029 14.1 0.8 1.9 1 0 0 1 1 1 1 Ki-ras-induced actin-interacting protein-IP3R-interacting domain TraU PF06834.11 EGD92565.1 - 0.053 12.8 1.4 0.16 11.2 1.4 1.7 1 1 0 1 1 1 0 TraU protein SPG4 PF17325.2 EGD92565.1 - 7.2 7.7 8.9 0.84 10.8 2.8 2.6 2 0 0 2 2 2 0 Stationary phase protein 4 Pkinase PF00069.25 EGD92566.1 - 1.2e-51 175.6 0.0 1.8e-51 175.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD92566.1 - 7e-33 114.0 0.0 1e-32 113.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EGD92566.1 - 3.7e-10 39.6 0.0 4.6e-07 29.4 0.0 2.5 2 0 0 2 2 2 2 Kinase-like Kdo PF06293.14 EGD92566.1 - 0.058 12.7 0.0 0.12 11.8 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EGD92566.1 - 0.1 12.5 0.0 0.19 11.6 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pep3_Vps18 PF05131.14 EGD92567.1 - 3e-45 153.7 0.0 8.4e-45 152.2 0.0 1.8 2 0 0 2 2 2 1 Pep3/Vps18/deep orange family Clathrin PF00637.20 EGD92567.1 - 2.1e-11 43.9 2.3 6.9e-06 26.0 0.0 3.3 3 0 0 3 3 3 2 Region in Clathrin and VPS Zn_ribbon_17 PF17120.5 EGD92567.1 - 0.00018 21.0 0.2 0.00037 20.0 0.2 1.5 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-C3HC4_2 PF13923.6 EGD92567.1 - 0.00096 19.0 1.0 0.0024 17.6 1.0 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EGD92567.1 - 0.001 19.0 0.8 0.0024 17.8 0.8 1.6 1 0 0 1 1 1 1 zinc-RING finger domain DUF2175 PF09943.9 EGD92567.1 - 0.0013 19.0 1.1 0.0098 16.2 0.1 2.5 2 0 0 2 2 2 1 Uncharacterized protein conserved in archaea (DUF2175) zf-RING_11 PF17123.5 EGD92567.1 - 0.002 17.9 4.3 0.002 17.9 4.3 1.9 2 0 0 2 2 2 1 RING-like zinc finger zf-RING_2 PF13639.6 EGD92567.1 - 0.0047 17.2 0.8 0.012 15.9 0.8 1.7 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 EGD92567.1 - 0.038 14.0 0.8 0.098 12.7 0.8 1.7 1 0 0 1 1 1 0 RING-type zinc-finger Vps39_2 PF10367.9 EGD92567.1 - 0.042 14.3 0.0 0.12 12.8 0.0 1.8 1 0 0 1 1 1 0 Vacuolar sorting protein 39 domain 2 zf-rbx1 PF12678.7 EGD92567.1 - 0.059 13.7 0.8 0.29 11.4 0.6 2.2 2 0 0 2 2 2 0 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 EGD92567.1 - 0.22 11.4 2.5 0.14 12.0 0.3 1.9 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) SNF2_N PF00176.23 EGD92568.1 - 1.2e-64 218.2 2.5 1.2e-64 218.2 2.5 1.9 2 0 0 2 2 2 1 SNF2 family N-terminal domain DBINO PF13892.6 EGD92568.1 - 3.5e-48 163.4 21.3 3.5e-48 163.4 21.3 5.3 5 1 1 6 6 6 1 DNA-binding domain Helicase_C PF00271.31 EGD92568.1 - 4.4e-19 68.8 0.0 1.3e-18 67.4 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EGD92568.1 - 1.6e-06 28.3 3.4 3.4e-06 27.2 0.0 2.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EGD92568.1 - 0.00019 21.2 0.0 0.00053 19.8 0.0 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase HDA2-3 PF11496.8 EGD92568.1 - 0.011 14.9 2.7 0.058 12.6 0.0 3.1 3 1 0 3 3 3 0 Class II histone deacetylase complex subunits 2 and 3 baeRF_family12 PF18856.1 EGD92568.1 - 0.015 15.9 0.2 0.015 15.9 0.2 5.3 6 1 0 6 6 6 0 Bacterial archaeo-eukaryotic release factor family 12 PET PF06297.14 EGD92568.1 - 0.46 10.8 7.7 2.4 8.5 7.7 2.3 1 0 0 1 1 1 0 PET Domain Orthopox_F8 PF05886.11 EGD92568.1 - 1.1 9.5 9.3 4.5 7.5 9.3 2.1 1 0 0 1 1 1 0 Orthopoxvirus F8 protein Na_H_Exchanger PF00999.21 EGD92569.1 - 6.2e-72 242.5 35.8 8e-72 242.1 35.8 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family Kelch_6 PF13964.6 EGD92569.1 - 0.13 12.6 0.0 0.39 11.1 0.0 1.8 1 0 0 1 1 1 0 Kelch motif Pox_EPC_I2-L1 PF12575.8 EGD92569.1 - 1.5 9.1 0.0 1.5 9.1 0.0 3.7 4 1 0 4 4 4 0 Poxvirus entry protein complex L1 and I2 CrgA PF06781.12 EGD92569.1 - 1.6 8.9 0.0 1.6 8.9 0.0 2.9 4 0 0 4 4 4 0 Cell division protein CrgA PepSY_TM PF03929.16 EGD92569.1 - 2.9 7.5 7.1 14 5.3 7.1 2.1 1 1 0 1 1 1 0 PepSY-associated TM region MFS_2 PF13347.6 EGD92572.1 - 1.5e-08 33.7 2.7 1.5e-08 33.7 2.7 2.1 2 0 0 2 2 2 1 MFS/sugar transport protein MFS_1 PF07690.16 EGD92572.1 - 1.7e-07 30.5 14.0 1.7e-07 30.5 14.0 3.1 3 1 0 3 3 3 2 Major Facilitator Superfamily PUCC PF03209.15 EGD92572.1 - 0.00041 19.5 1.3 0.00076 18.6 1.3 1.4 1 0 0 1 1 1 1 PUCC protein STE PF02200.16 EGD92573.1 - 1.6e-56 189.4 0.1 2.8e-56 188.7 0.1 1.4 1 0 0 1 1 1 1 STE like transcription factor zf-C2H2 PF00096.26 EGD92573.1 - 2.4e-11 43.4 10.8 6.7e-07 29.4 0.9 2.9 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EGD92573.1 - 2.3e-09 37.3 4.2 2.3e-09 37.3 4.2 3.4 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 EGD92573.1 - 1.2e-07 31.9 8.8 0.00099 19.8 0.5 2.9 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_6 PF13912.6 EGD92573.1 - 0.0026 17.7 0.3 0.0026 17.7 0.3 2.6 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EGD92573.1 - 0.0071 16.6 0.3 0.12 12.7 0.1 2.5 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding FYDLN_acid PF09538.10 EGD92573.1 - 0.02 15.6 2.3 0.052 14.2 2.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) zinc_ribbon_9 PF14369.6 EGD92573.1 - 0.063 13.5 0.1 0.17 12.1 0.1 1.7 1 0 0 1 1 1 0 zinc-ribbon zf-Di19 PF05605.12 EGD92573.1 - 0.076 13.3 0.4 0.076 13.3 0.4 2.3 1 1 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding IBR PF01485.21 EGD92573.1 - 0.14 12.4 0.4 0.33 11.2 0.4 1.5 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain zf-TRAF PF02176.18 EGD92573.1 - 0.3 11.8 2.9 0.53 11.0 2.9 1.4 1 0 0 1 1 1 0 TRAF-type zinc finger zf-C2HC_2 PF13913.6 EGD92573.1 - 2.2 8.2 4.3 5.3 7.0 0.1 2.5 2 0 0 2 2 2 0 zinc-finger of a C2HC-type zf-H2C2_5 PF13909.6 EGD92573.1 - 6.2 6.7 10.4 14 5.5 0.8 3.0 2 0 0 2 2 2 0 C2H2-type zinc-finger domain His_biosynth PF00977.21 EGD92575.1 - 3.5e-33 115.0 0.0 4.1e-33 114.8 0.0 1.0 1 0 0 1 1 1 1 Histidine biosynthesis protein Ribul_P_3_epim PF00834.19 EGD92575.1 - 0.09 12.2 0.0 0.16 11.3 0.0 1.4 1 0 0 1 1 1 0 Ribulose-phosphate 3 epimerase family DUF2463 PF09591.10 EGD92576.1 - 0.012 15.5 0.3 0.013 15.4 0.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2463) PMT_4TMC PF16192.5 EGD92576.1 - 0.066 12.8 0.2 0.075 12.6 0.2 1.0 1 0 0 1 1 1 0 C-terminal four TMM region of protein-O-mannosyltransferase SNARE PF05739.19 EGD92576.1 - 0.75 9.8 3.2 0.89 9.6 2.4 1.6 2 0 0 2 2 2 0 SNARE domain Radical_SAM_C PF16199.5 EGD92577.1 - 1.6e-32 111.3 0.1 4.6e-32 109.9 0.0 1.8 2 0 0 2 2 2 1 Radical_SAM C-terminal domain Radical_SAM PF04055.21 EGD92577.1 - 1.8e-19 70.7 0.1 7e-19 68.8 0.0 2.0 2 0 0 2 2 2 1 Radical SAM superfamily Acetyltransf_1 PF00583.25 EGD92577.1 - 3.2e-10 40.3 0.0 6.1e-10 39.4 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EGD92577.1 - 1.4e-06 28.3 0.2 1.3e-05 25.1 0.0 2.3 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EGD92577.1 - 0.089 13.2 0.0 0.18 12.3 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain CoA_binding PF02629.19 EGD92578.1 - 5.3e-27 94.3 1.8 5.3e-27 94.3 1.8 2.0 2 0 0 2 2 2 1 CoA binding domain Ligase_CoA PF00549.19 EGD92578.1 - 2.1e-22 79.6 0.2 3.6e-22 78.8 0.2 1.4 1 0 0 1 1 1 1 CoA-ligase Succ_CoA_lig PF13607.6 EGD92578.1 - 4.4e-08 33.0 0.1 9.4e-08 32.0 0.1 1.6 1 0 0 1 1 1 1 Succinyl-CoA ligase like flavodoxin domain CoA_binding_2 PF13380.6 EGD92578.1 - 1.3e-05 25.6 0.1 2.9e-05 24.5 0.1 1.6 1 0 0 1 1 1 1 CoA binding domain Ribosomal_L5_C PF00673.21 EGD92579.1 - 7.2e-28 96.6 0.0 1.4e-27 95.7 0.0 1.5 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.19 EGD92579.1 - 1.2e-05 25.5 0.0 2.3e-05 24.7 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L5 Pkinase PF00069.25 EGD92580.1 - 2.8e-69 233.4 0.0 1.1e-68 231.5 0.0 1.9 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD92580.1 - 2e-47 161.7 0.0 4.6e-47 160.5 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase Ras_bdg_2 PF14847.6 EGD92580.1 - 4e-28 97.7 0.0 8.1e-28 96.7 0.0 1.5 1 0 0 1 1 1 1 Ras-binding domain of Byr2 SAM_1 PF00536.30 EGD92580.1 - 3.9e-16 59.2 0.1 8.8e-16 58.1 0.1 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 EGD92580.1 - 1.1e-13 51.0 0.0 2.5e-13 49.9 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Kinase-like PF14531.6 EGD92580.1 - 5.9e-08 32.4 0.0 0.00027 20.4 0.0 2.3 2 0 0 2 2 2 2 Kinase-like RA PF00788.23 EGD92580.1 - 8.5e-05 23.1 0.0 0.00016 22.2 0.0 1.4 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain Pkinase_fungal PF17667.1 EGD92580.1 - 0.0047 15.7 0.0 0.0047 15.7 0.0 1.9 3 0 0 3 3 3 1 Fungal protein kinase Kdo PF06293.14 EGD92580.1 - 0.078 12.3 0.0 0.15 11.4 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family SAM_4 PF18017.1 EGD92580.1 - 0.11 12.5 0.0 0.24 11.4 0.0 1.5 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) Seadorna_VP7 PF07387.11 EGD92580.1 - 0.18 10.8 0.1 0.91 8.5 0.0 2.1 3 0 0 3 3 3 0 Seadornavirus VP7 MSA-2c PF12238.8 EGD92580.1 - 0.21 11.6 3.0 1.2 9.2 0.0 2.9 2 0 0 2 2 2 0 Merozoite surface antigen 2c Fungal_trans PF04082.18 EGD92581.1 - 1.3e-12 47.4 0.7 2.3e-12 46.5 0.1 1.7 2 0 0 2 2 2 1 Fungal specific transcription factor domain zf-C2H2_jaz PF12171.8 EGD92582.1 - 0.036 14.4 0.3 0.24 11.7 0.0 2.5 2 1 1 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 EGD92582.1 - 0.13 13.2 7.2 3 8.9 0.1 3.7 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2 PF00096.26 EGD92582.1 - 0.95 10.1 11.4 2.4 8.8 0.2 3.6 3 0 0 3 3 3 0 Zinc finger, C2H2 type MMR_HSR1 PF01926.23 EGD92583.1 - 2e-16 60.1 0.4 2e-14 53.6 0.1 2.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EGD92583.1 - 2.3e-06 27.2 0.7 3.6e-05 23.3 0.2 2.2 2 0 0 2 2 2 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 EGD92583.1 - 6.4e-05 22.9 0.2 0.017 15.1 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase AIG1 PF04548.16 EGD92583.1 - 0.0025 17.2 0.1 0.0052 16.1 0.1 1.5 1 0 0 1 1 1 1 AIG1 family Dynamin_N PF00350.23 EGD92583.1 - 0.27 11.3 6.8 0.32 11.0 0.5 3.4 3 1 1 4 4 4 0 Dynamin family LTV PF04180.14 EGD92584.1 - 8.8e-118 394.4 17.2 1e-117 394.2 17.2 1.0 1 0 0 1 1 1 1 Low temperature viability protein PLDc_2 PF13091.6 EGD92585.1 - 4.4e-15 55.8 0.0 1.7e-08 34.4 0.0 2.2 2 0 0 2 2 2 2 PLD-like domain PLDc PF00614.22 EGD92585.1 - 8.6e-09 35.2 2.5 0.0025 17.9 0.3 3.2 2 1 0 2 2 2 2 Phospholipase D Active site motif NDUFA12 PF05071.16 EGD92586.1 - 1e-32 112.8 2.7 1.3e-32 112.5 2.7 1.1 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase subunit NDUFA12 TPR_2 PF07719.17 EGD92587.1 - 9.4e-09 34.7 0.8 0.096 12.8 0.1 6.1 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_14 PF13428.6 EGD92587.1 - 1.9e-08 34.5 11.7 0.082 13.8 0.0 7.5 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_8 PF13181.6 EGD92587.1 - 5.4e-07 29.3 0.3 0.066 13.4 0.0 5.9 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_19 PF14559.6 EGD92587.1 - 2e-06 28.2 6.9 0.053 14.0 0.0 4.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.28 EGD92587.1 - 0.00061 19.5 2.4 0.082 12.8 0.1 4.7 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_17 PF13431.6 EGD92587.1 - 0.0019 18.4 0.0 22 5.7 0.0 4.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 EGD92587.1 - 0.0078 16.8 8.1 6.9 7.4 0.0 6.0 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_6 PF13174.6 EGD92587.1 - 1.9 9.3 3.6 8.4 7.3 0.1 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat SNF2_N PF00176.23 EGD92588.1 - 8.7e-71 238.5 0.0 1.5e-70 237.7 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EGD92588.1 - 7.8e-15 55.2 0.0 5.6e-14 52.4 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HIRAN PF08797.11 EGD92588.1 - 9.5e-15 54.3 0.0 2.1e-14 53.2 0.0 1.6 1 0 0 1 1 1 1 HIRAN domain zf-C3HC4_2 PF13923.6 EGD92588.1 - 3.7e-10 39.5 7.4 1.2e-09 37.9 7.4 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EGD92588.1 - 1.1e-08 35.3 6.9 1.1e-08 35.3 6.9 2.3 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_3 PF13920.6 EGD92588.1 - 6.4e-08 32.3 8.1 6.4e-08 32.3 8.1 2.8 4 0 0 4 4 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EGD92588.1 - 1e-06 28.5 8.1 3e-06 27.0 8.1 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EGD92588.1 - 1.1e-06 28.8 3.6 3.5e-06 27.2 3.6 1.9 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_11 PF17123.5 EGD92588.1 - 1.3e-05 24.8 2.8 1.3e-05 24.8 2.8 2.8 3 0 0 3 3 3 1 RING-like zinc finger zf-RING_5 PF14634.6 EGD92588.1 - 1.6e-05 24.8 5.1 1.6e-05 24.8 5.1 1.9 2 0 0 2 2 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EGD92588.1 - 2.7e-05 24.1 8.0 2.7e-05 24.1 8.0 2.1 2 0 0 2 2 2 1 RING-type zinc-finger DEAD PF00270.29 EGD92588.1 - 9.7e-05 22.2 0.0 0.00022 21.0 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Prok-RING_4 PF14447.6 EGD92588.1 - 0.00011 22.0 8.7 0.00028 20.7 8.7 1.8 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 EGD92588.1 - 0.0009 19.4 8.5 0.0019 18.3 8.5 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-Nse PF11789.8 EGD92588.1 - 0.0019 18.0 4.3 0.019 14.8 4.6 2.3 2 0 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit U-box PF04564.15 EGD92588.1 - 0.017 15.3 0.1 0.089 13.0 0.0 2.2 2 0 0 2 2 2 0 U-box domain zf-ANAPC11 PF12861.7 EGD92588.1 - 0.16 12.0 1.8 0.6 10.2 1.9 1.9 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger MBOAT_2 PF13813.6 EGD92589.1 - 6.9e-21 74.3 2.1 1.4e-20 73.3 2.1 1.6 1 0 0 1 1 1 1 Membrane bound O-acyl transferase family Big_4 PF07532.11 EGD92589.1 - 0.11 12.3 0.0 0.3 10.9 0.0 1.7 1 0 0 1 1 1 0 Bacterial Ig-like domain (group 4) HXXEE PF13787.6 EGD92589.1 - 5.7 7.8 7.3 0.63 10.9 0.5 2.6 3 1 0 3 3 3 0 Protein of unknown function with HXXEE motif RIX1 PF08167.12 EGD92590.1 - 5.5e-60 202.3 1.1 1.6e-59 200.8 1.1 1.9 1 0 0 1 1 1 1 rRNA processing/ribosome biogenesis EpCAM_N PF18635.1 EGD92590.1 - 1.7 8.9 3.9 0.76 10.0 0.9 2.0 2 0 0 2 2 2 0 Epithelial cell adhesion molecule N-terminal domain SNF2_N PF00176.23 EGD92591.1 - 3.8e-46 157.4 0.2 7.8e-46 156.4 0.2 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EGD92591.1 - 2.5e-18 66.4 0.0 6.4e-18 65.1 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EGD92591.1 - 9.4e-09 35.5 0.0 6.4e-08 32.8 0.0 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 EGD92591.1 - 3.3e-05 23.2 0.1 0.0001 21.6 0.0 1.8 2 0 0 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase SWI2_SNF2 PF18766.1 EGD92591.1 - 7.7e-05 22.5 0.0 0.04 13.6 0.0 2.7 3 0 0 3 3 3 2 SWI2/SNF2 ATPase SAM_1 PF00536.30 EGD92591.1 - 0.016 15.7 0.0 0.049 14.1 0.0 1.9 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 EGD92591.1 - 0.027 14.6 0.0 0.078 13.1 0.0 1.8 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) GSH_synth_ATP PF03917.17 EGD92592.1 - 4.9e-134 446.8 0.0 5.6e-134 446.6 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic glutathione synthase, ATP binding domain GSH_synthase PF03199.15 EGD92592.1 - 3.1e-27 95.0 0.0 5.3e-27 94.3 0.0 1.4 1 0 0 1 1 1 1 Eukaryotic glutathione synthase Bestrophin PF01062.21 EGD92596.1 - 1.5e-35 123.0 0.0 2.3e-35 122.4 0.0 1.1 1 0 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel Aminotran_3 PF00202.21 EGD92597.1 - 8.9e-125 416.5 0.0 1e-124 416.3 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.21 EGD92597.1 - 0.0091 15.2 0.0 0.013 14.7 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Orbi_NS3 PF01616.16 EGD92597.1 - 0.11 12.2 0.0 0.2 11.3 0.0 1.3 1 0 0 1 1 1 0 Orbivirus NS3 Spt4 PF06093.13 EGD92598.1 - 2.2e-32 111.0 0.2 2.6e-32 110.7 0.2 1.1 1 0 0 1 1 1 1 Spt4/RpoE2 zinc finger Coronavirus_5 PF05528.11 EGD92598.1 - 0.06 13.3 0.1 0.092 12.7 0.1 1.4 1 1 0 1 1 1 0 Coronavirus gene 5 protein PPP5 PF08321.12 EGD92599.1 - 1.4e-34 118.2 0.3 3.3e-34 117.1 0.3 1.7 1 0 0 1 1 1 1 PPP5 TPR repeat region Metallophos PF00149.28 EGD92599.1 - 1.9e-30 106.9 0.0 2.7e-30 106.4 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase TPR_1 PF00515.28 EGD92599.1 - 1.4e-12 46.9 4.7 0.00012 21.8 0.0 3.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.6 EGD92599.1 - 2.4e-11 43.1 5.0 4.3e-07 29.5 0.3 3.3 3 0 0 3 3 3 2 TPR repeat TPR_2 PF07719.17 EGD92599.1 - 3.5e-10 39.2 4.4 0.0011 18.9 0.9 3.8 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 EGD92599.1 - 1.5e-07 31.9 1.9 0.0057 17.3 0.1 3.3 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_9 PF13371.6 EGD92599.1 - 4.8e-06 26.6 0.1 0.0077 16.4 0.0 2.5 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.6 EGD92599.1 - 0.00062 20.2 0.6 0.55 10.8 0.0 2.6 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 EGD92599.1 - 0.0011 19.2 0.4 0.0055 17.0 0.4 2.1 1 1 0 1 1 1 1 Tetratricopeptide repeat TPR_17 PF13431.6 EGD92599.1 - 0.0021 18.3 0.8 5.2 7.7 0.0 3.5 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_6 PF13174.6 EGD92599.1 - 0.0026 18.3 1.2 3.6 8.4 0.0 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 EGD92599.1 - 0.0083 16.9 1.4 10 7.2 0.1 3.2 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 EGD92599.1 - 0.04 14.1 1.1 0.28 11.5 0.0 2.9 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_7 PF13176.6 EGD92599.1 - 0.076 13.1 0.3 0.88 9.8 0.1 2.6 3 0 0 3 3 3 0 Tetratricopeptide repeat MIT PF04212.18 EGD92599.1 - 0.64 10.1 6.6 0.82 9.8 0.3 2.7 3 0 0 3 3 3 0 MIT (microtubule interacting and transport) domain DUF89 PF01937.19 EGD92600.1 - 7.5e-135 449.4 0.2 8.6e-135 449.2 0.2 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF89 CENP-F_leu_zip PF10473.9 EGD92600.1 - 0.12 12.4 2.4 0.15 12.1 0.2 2.2 3 0 0 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Cut12 PF11500.8 EGD92601.1 - 2.7e-47 160.3 14.2 2.7e-47 160.3 14.2 4.1 4 1 1 5 5 5 1 Spindle pole body formation-associated protein DUF2730 PF10805.8 EGD92601.1 - 1.1 9.4 6.9 0.45 10.6 0.3 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2730) HGTP_anticodon2 PF12745.7 EGD92602.1 - 1.9e-84 283.3 3.2 3.6e-84 282.4 0.0 2.2 2 0 0 2 2 2 1 Anticodon binding domain of tRNAs Pkinase PF00069.25 EGD92602.1 - 2e-69 233.9 0.0 1.1e-36 126.6 0.0 3.6 3 0 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.17 EGD92602.1 - 1.4e-35 122.8 0.0 1.7e-18 66.8 0.0 3.6 3 0 0 3 3 3 3 Protein tyrosine kinase RWD PF05773.22 EGD92602.1 - 6.8e-18 65.0 2.2 1.1e-17 64.4 0.6 2.3 2 0 0 2 2 2 1 RWD domain tRNA-synt_His PF13393.6 EGD92602.1 - 2.4e-11 43.5 1.2 1.3e-10 41.0 0.0 2.1 2 0 0 2 2 2 1 Histidyl-tRNA synthetase APH PF01636.23 EGD92602.1 - 0.0046 16.9 0.1 0.0046 16.9 0.1 2.2 2 0 0 2 2 2 1 Phosphotransferase enzyme family gpUL132 PF11359.8 EGD92602.1 - 0.066 12.8 0.1 0.24 10.9 0.1 1.8 2 0 0 2 2 2 0 Glycoprotein UL132 Pkinase_fungal PF17667.1 EGD92602.1 - 0.85 8.3 3.0 0.53 9.0 0.0 2.0 2 0 0 2 2 2 0 Fungal protein kinase Torus PF16131.5 EGD92603.1 - 2e-45 154.0 1.9 4.2e-45 152.9 0.0 2.4 3 0 0 3 3 3 1 Torus domain zf_CCCH_4 PF18345.1 EGD92603.1 - 0.00028 20.8 1.0 0.00045 20.2 1.0 1.3 1 0 0 1 1 1 1 Zinc finger domain RRM_1 PF00076.22 EGD92603.1 - 0.00028 20.6 0.0 0.00062 19.5 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCCH PF00642.24 EGD92603.1 - 0.025 14.5 1.7 0.045 13.7 1.7 1.4 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Ifi-6-16 PF06140.13 EGD92603.1 - 0.05 13.5 0.4 0.087 12.8 0.4 1.3 1 0 0 1 1 1 0 Interferon-induced 6-16 family zf-CCCH_4 PF18044.1 EGD92603.1 - 1.1 9.1 3.8 1.8 8.5 3.8 1.3 1 0 0 1 1 1 0 CCCH-type zinc finger MMR_HSR1_Xtn PF16897.5 EGD92604.1 - 1.5e-34 118.2 1.3 8.9e-34 115.7 0.4 2.2 2 0 0 2 2 2 1 C-terminal region of MMR_HSR1 domain MMR_HSR1 PF01926.23 EGD92604.1 - 1.8e-20 73.1 0.0 4.5e-20 71.8 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase TGS PF02824.21 EGD92604.1 - 8.6e-18 64.1 0.4 1.9e-17 63.1 0.1 1.7 2 0 0 2 2 2 1 TGS domain FeoB_N PF02421.18 EGD92604.1 - 1.3e-12 47.6 0.0 1.9e-12 47.0 0.0 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 EGD92604.1 - 3.5e-05 23.9 0.3 0.04 14.0 0.0 2.5 1 1 1 2 2 2 2 Dynamin family AIG1 PF04548.16 EGD92604.1 - 0.046 13.0 0.0 0.074 12.4 0.0 1.3 1 0 0 1 1 1 0 AIG1 family MeaB PF03308.16 EGD92604.1 - 0.082 11.9 0.1 0.17 10.8 0.1 1.6 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Roc PF08477.13 EGD92604.1 - 0.1 12.8 0.1 3.8 7.7 0.0 2.4 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase MCM PF00493.23 EGD92604.1 - 0.12 11.5 0.1 0.27 10.3 0.0 1.6 2 0 0 2 2 2 0 MCM P-loop domain DnaJ_C PF01556.18 EGD92605.1 - 4.7e-36 124.1 0.5 6.2e-36 123.7 0.5 1.1 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 EGD92605.1 - 2.7e-28 97.9 1.7 4.8e-28 97.1 1.7 1.4 1 0 0 1 1 1 1 DnaJ domain PIG-X PF08320.12 EGD92606.1 - 2.3e-70 236.8 0.1 3.6e-70 236.2 0.1 1.3 1 0 0 1 1 1 1 PIG-X / PBN1 RFX_DNA_binding PF02257.15 EGD92607.1 - 5.5e-27 94.2 0.1 1.4e-26 92.9 0.1 1.7 1 0 0 1 1 1 1 RFX DNA-binding domain TB2_DP1_HVA22 PF03134.19 EGD92608.1 - 5.1e-27 93.6 9.5 5.1e-27 93.6 9.5 1.5 2 0 0 2 2 2 1 TB2/DP1, HVA22 family ATG101 PF07855.12 EGD92609.1 - 8.2e-53 178.5 0.1 9.5e-53 178.3 0.1 1.0 1 0 0 1 1 1 1 Autophagy-related protein 101 DUF2922 PF11148.8 EGD92609.1 - 0.0077 15.9 0.2 0.019 14.6 0.2 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2922) Peroxin-3 PF04882.12 EGD92610.1 - 1.4e-166 555.2 0.1 1.6e-166 554.9 0.1 1.0 1 0 0 1 1 1 1 Peroxin-3 Na_H_Exchanger PF00999.21 EGD92611.1 - 2.4e-59 201.0 44.5 3.6e-59 200.5 44.5 1.2 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family UDPG_MGDP_dh_N PF03721.14 EGD92611.1 - 0.093 12.3 0.0 0.17 11.4 0.0 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain MFS_1 PF07690.16 EGD92612.1 - 6.7e-38 130.5 28.8 6.7e-38 130.5 28.8 1.3 2 0 0 2 2 2 1 Major Facilitator Superfamily DUF3464 PF11947.8 EGD92612.1 - 0.28 10.9 0.6 1.5 8.5 0.0 2.3 2 1 0 2 2 2 0 Photosynthesis affected mutant 68 Acyl_transf_3 PF01757.22 EGD92612.1 - 1.9 7.4 36.4 2.1 7.3 16.3 3.1 2 1 1 3 3 3 0 Acyltransferase family zf-C4H2 PF10146.9 EGD92613.1 - 0.025 14.9 6.0 0.053 13.8 6.0 1.5 1 0 0 1 1 1 0 Zinc finger-containing protein SRP-alpha_N PF04086.13 EGD92613.1 - 0.26 11.2 2.6 0.49 10.3 2.6 1.4 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal PRIMA1 PF16101.5 EGD92613.1 - 0.28 11.2 6.9 0.092 12.8 3.2 2.1 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 TFIIA PF03153.13 EGD92613.1 - 3.1 7.7 13.6 0.43 10.5 9.3 1.6 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Cytochrom_B558a PF05038.13 EGD92613.1 - 5.1 6.6 4.6 11 5.5 4.6 1.6 1 0 0 1 1 1 0 Cytochrome Cytochrome b558 alpha-subunit ThiF PF00899.21 EGD92614.1 - 2e-32 112.5 0.0 2.5e-32 112.2 0.0 1.0 1 0 0 1 1 1 1 ThiF family Ytp1 PF10355.9 EGD92615.1 - 3.2e-69 233.2 18.3 3.2e-69 233.2 18.3 2.2 2 1 0 2 2 2 1 Protein of unknown function (Ytp1) DUF2427 PF10348.9 EGD92615.1 - 5.8e-32 109.6 3.3 5.8e-32 109.6 3.3 3.2 4 0 0 4 4 4 1 Domain of unknown function (DUF2427) ExoD PF06055.12 EGD92615.1 - 0.11 11.9 0.0 0.11 11.9 0.0 3.1 4 0 0 4 4 4 0 Exopolysaccharide synthesis, ExoD DUF3180 PF11377.8 EGD92615.1 - 0.12 12.6 8.6 1.8 8.7 5.5 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF3180) DUF973 PF06157.11 EGD92615.1 - 0.18 10.8 8.7 0.43 9.6 8.7 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF973) Swi5 PF07061.11 EGD92616.1 - 5.4e-28 96.9 0.2 7.1e-28 96.5 0.2 1.2 1 0 0 1 1 1 1 Swi5 DUF641 PF04859.12 EGD92616.1 - 0.077 13.3 0.0 0.11 12.9 0.0 1.2 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) ABC_tran_CTD PF16326.5 EGD92616.1 - 0.12 12.6 2.6 0.21 11.9 2.6 1.3 1 0 0 1 1 1 0 ABC transporter C-terminal domain HOOK PF05622.12 EGD92617.1 - 0.064 11.4 10.4 4.9 5.2 9.2 2.2 2 0 0 2 2 2 0 HOOK protein Spc7 PF08317.11 EGD92617.1 - 0.12 11.3 11.7 0.065 12.1 8.9 1.8 2 0 0 2 2 2 0 Spc7 kinetochore protein SKA1 PF07160.12 EGD92617.1 - 0.14 12.0 5.7 0.037 13.9 2.4 1.8 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 1 Pox_A_type_inc PF04508.12 EGD92617.1 - 0.21 11.5 4.7 2.1 8.3 1.0 2.9 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat FPP PF05911.11 EGD92617.1 - 0.28 9.3 12.5 2 6.5 8.9 2.1 2 0 0 2 2 2 0 Filament-like plant protein, long coiled-coil FapA PF03961.13 EGD92617.1 - 0.34 9.5 4.3 0.64 8.6 4.3 1.4 1 0 0 1 1 1 0 Flagellar Assembly Protein A Cauli_AT PF03233.13 EGD92617.1 - 0.4 10.6 5.8 0.4 10.6 2.3 2.2 2 0 0 2 2 2 0 Aphid transmission protein Filament PF00038.21 EGD92617.1 - 0.52 9.9 12.6 0.073 12.6 8.4 1.7 2 0 0 2 2 2 0 Intermediate filament protein Golgin_A5 PF09787.9 EGD92617.1 - 0.61 9.5 9.7 1.3 8.4 9.7 1.5 1 0 0 1 1 1 0 Golgin subfamily A member 5 DUF2570 PF10828.8 EGD92617.1 - 0.66 9.8 9.6 1.1 9.1 8.4 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2570) PRKG1_interact PF15898.5 EGD92617.1 - 0.73 10.8 16.2 59 4.6 0.1 3.7 3 1 0 3 3 3 0 cGMP-dependent protein kinase interacting domain ALMT PF11744.8 EGD92617.1 - 1.5 7.6 4.5 2.5 6.8 4.5 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter CENP-Q PF13094.6 EGD92617.1 - 1.6 8.9 15.8 27 4.9 15.8 2.3 1 1 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit Exonuc_VII_L PF02601.15 EGD92617.1 - 4.5 6.8 10.0 0.55 9.7 5.0 1.9 2 0 0 2 2 2 0 Exonuclease VII, large subunit V_ATPase_I PF01496.19 EGD92617.1 - 5.4 4.8 6.2 8.2 4.2 6.2 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family TMPIT PF07851.13 EGD92617.1 - 6.4 5.9 6.2 11 5.1 6.2 1.3 1 0 0 1 1 1 0 TMPIT-like protein Glycos_transf_2 PF00535.26 EGD92618.1 - 3.6e-23 82.2 0.0 4e-21 75.6 0.0 2.9 1 1 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 EGD92618.1 - 0.0001 22.3 0.0 0.36 10.7 0.0 3.0 2 1 1 3 3 3 2 Glycosyltransferase like family 2 Dicty_CAR PF05462.11 EGD92619.1 - 1.6e-11 43.9 7.6 1.6e-11 43.9 7.6 2.0 2 0 0 2 2 2 1 Slime mold cyclic AMP receptor 7tm_2 PF00002.24 EGD92619.1 - 2.6e-06 26.9 11.3 2.5e-05 23.7 10.4 2.3 2 1 0 2 2 2 1 7 transmembrane receptor (Secretin family) 7tm_1 PF00001.21 EGD92619.1 - 1.9e-05 24.2 0.0 3e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Frizzled PF01534.17 EGD92619.1 - 0.00038 19.6 12.6 0.14 11.2 12.6 2.3 1 1 0 1 1 1 1 Frizzled/Smoothened family membrane region Git3 PF11710.8 EGD92619.1 - 0.00041 20.2 6.7 0.00041 20.2 6.7 1.7 2 0 0 2 2 2 1 G protein-coupled glucose receptor regulating Gpa2 7TM_GPCR_Srsx PF10320.9 EGD92619.1 - 0.0031 16.9 2.1 0.0052 16.2 2.1 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx SUIM_assoc PF16619.5 EGD92619.1 - 0.06 13.4 4.8 0.15 12.2 4.8 1.6 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 GPR_Gpa2_C PF11970.8 EGD92619.1 - 0.15 12.1 2.1 0.31 11.2 0.4 2.3 2 0 0 2 2 2 0 G protein-coupled glucose receptor regulating Gpa2 C-term DUF2304 PF10066.9 EGD92619.1 - 9.5 6.5 9.4 1.3 9.3 0.2 3.2 3 1 0 3 3 3 0 Uncharacterized conserved protein (DUF2304) Kdo PF06293.14 EGD92621.1 - 0.0009 18.7 0.0 0.0017 17.7 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EGD92621.1 - 0.0057 16.6 0.1 0.0057 16.6 0.1 2.8 2 1 1 3 3 3 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EGD92621.1 - 0.065 12.8 0.4 0.18 11.4 0.0 1.8 2 0 0 2 2 2 0 Choline/ethanolamine kinase CDC45 PF02724.14 EGD92621.1 - 2.8 6.1 5.8 0.13 10.5 0.3 1.5 2 0 0 2 2 2 0 CDC45-like protein Autophagy_N PF03986.13 EGD92622.1 - 5e-45 152.8 1.7 6.4e-45 152.5 0.0 1.8 2 0 0 2 2 2 1 Autophagocytosis associated protein (Atg3), N-terminal domain Autophagy_C PF10381.9 EGD92622.1 - 1.3e-15 56.5 0.5 2.3e-15 55.8 0.5 1.4 1 0 0 1 1 1 1 Autophagocytosis associated protein C-terminal Autophagy_act_C PF03987.15 EGD92622.1 - 4.6e-14 52.8 0.1 7.6e-14 52.0 0.1 1.4 1 0 0 1 1 1 1 Autophagocytosis associated protein, active-site domain TFIIB PF00382.19 EGD92623.1 - 0.00052 20.0 0.0 0.035 14.1 0.0 2.5 2 1 0 2 2 2 2 Transcription factor TFIIB repeat EST1_DNA_bind PF10373.9 EGD92624.1 - 3.6e-10 39.8 3.9 3.6e-10 39.8 3.9 2.8 2 1 0 2 2 2 1 Est1 DNA/RNA binding domain 5_nucleotid PF05761.14 EGD92624.1 - 0.039 12.9 0.7 0.067 12.1 0.7 1.3 1 0 0 1 1 1 0 5' nucleotidase family PI3K_1B_p101 PF10486.9 EGD92625.1 - 0.42 8.3 3.7 0.52 8.0 3.7 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit CDC45 PF02724.14 EGD92625.1 - 0.65 8.2 5.9 0.91 7.7 5.9 1.1 1 0 0 1 1 1 0 CDC45-like protein NUDIX PF00293.28 EGD92627.1 - 5.8e-09 36.1 0.0 9.4e-09 35.4 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain NUDIX PF00293.28 EGD92628.1 - 8.1e-16 58.3 0.0 1.5e-15 57.4 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain TetR_C_30 PF17939.1 EGD92628.1 - 0.16 12.2 0.0 0.26 11.5 0.0 1.3 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain HAD_2 PF13419.6 EGD92629.1 - 3.7e-19 69.5 0.0 4.8e-19 69.1 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase NIF PF03031.18 EGD92629.1 - 8.9e-07 28.8 0.0 2e-05 24.4 0.0 2.1 1 1 0 1 1 1 1 NLI interacting factor-like phosphatase Hydrolase PF00702.26 EGD92629.1 - 2.4e-05 24.7 0.1 0.00016 22.0 0.1 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EGD92629.1 - 0.0016 18.4 0.0 0.0029 17.7 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like DUF4853 PF16145.5 EGD92629.1 - 0.13 12.4 0.0 0.23 11.6 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4853) Rit1_C PF17184.4 EGD92630.1 - 2.9e-97 325.4 0.0 3.7e-97 325.0 0.0 1.1 1 0 0 1 1 1 1 Rit1 N-terminal domain Init_tRNA_PT PF04179.12 EGD92630.1 - 7e-17 61.7 0.0 1.4e-16 60.8 0.0 1.5 1 0 0 1 1 1 1 Rit1 DUSP-like domain Aldo_ket_red PF00248.21 EGD92631.1 - 1.7e-10 40.6 0.0 2.3e-10 40.2 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family Tannase PF07519.11 EGD92633.1 - 1.1e-92 311.4 0.1 3.6e-92 309.7 0.1 1.7 1 1 0 1 1 1 1 Tannase and feruloyl esterase Peptidase_S9 PF00326.21 EGD92633.1 - 0.00024 20.6 0.0 0.18 11.2 0.0 2.2 2 0 0 2 2 2 2 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 EGD92633.1 - 0.0091 15.3 0.0 0.23 10.7 0.0 2.1 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Zn_clus PF00172.18 EGD92634.1 - 7.4e-08 32.4 13.4 1.3e-07 31.6 13.4 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PHD20L1_u1 PF16660.5 EGD92634.1 - 0.14 12.9 0.7 0.32 11.8 0.7 1.6 1 0 0 1 1 1 0 PHD finger protein 20-like protein 1 Sec8_exocyst PF04048.14 EGD92635.1 - 1.1e-39 135.5 2.0 1.4e-39 135.2 0.6 1.9 2 0 0 2 2 2 1 Sec8 exocyst complex component specific domain Vps54_N PF10475.9 EGD92635.1 - 1.8e-06 27.5 1.1 3.8e-06 26.4 1.1 1.4 1 0 0 1 1 1 1 Vacuolar-sorting protein 54, of GARP complex COG2 PF06148.11 EGD92635.1 - 1.2 9.2 3.1 0.72 9.9 0.5 2.0 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 RNA_pol_Rpc82 PF05645.13 EGD92636.1 - 3.4e-25 89.3 0.1 7.4e-15 55.4 0.0 3.6 2 1 2 4 4 4 3 RNA polymerase III subunit RPC82 HTH_9 PF08221.11 EGD92636.1 - 1.8e-22 79.2 2.9 5.1e-15 55.3 0.2 4.1 4 0 0 4 4 4 3 RNA polymerase III subunit RPC82 helix-turn-helix domain TFIIE_alpha PF02002.17 EGD92636.1 - 3e-08 33.5 0.0 4.1e-06 26.6 0.1 2.7 2 1 0 2 2 2 1 TFIIE alpha subunit FAM176 PF14851.6 EGD92636.1 - 0.03 14.0 1.5 1.4 8.5 0.5 2.8 2 0 0 2 2 2 0 FAM176 family Peptidase_M16 PF00675.20 EGD92637.1 - 3.9e-17 62.6 0.0 7e-17 61.8 0.0 1.4 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 EGD92637.1 - 3.9e-12 46.6 0.0 7e-12 45.7 0.0 1.4 1 0 0 1 1 1 1 Peptidase M16 inactive domain Mito_carr PF00153.27 EGD92638.1 - 4.4e-24 84.2 6.3 2.4e-10 40.2 0.0 3.4 3 1 0 3 3 3 3 Mitochondrial carrier protein Citrate_synt PF00285.21 EGD92639.1 - 3.3e-100 335.7 0.0 4.3e-100 335.3 0.0 1.1 1 0 0 1 1 1 1 Citrate synthase, C-terminal domain Eclosion PF04736.12 EGD92639.1 - 0.13 12.0 0.0 0.23 11.2 0.0 1.3 1 0 0 1 1 1 0 Eclosion hormone DSPc PF00782.20 EGD92640.1 - 8.8e-20 70.9 0.0 4.7e-17 62.1 0.0 2.1 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EGD92640.1 - 0.0063 16.1 1.1 0.012 15.1 0.3 1.9 1 1 1 2 2 2 1 Protein-tyrosine phosphatase HeLo PF14479.6 EGD92640.1 - 0.14 11.9 0.0 0.23 11.3 0.0 1.2 1 0 0 1 1 1 0 Prion-inhibition and propagation CTD_bind PF04818.13 EGD92642.1 - 0.077 13.8 0.0 0.16 12.8 0.0 1.6 1 0 0 1 1 1 0 RNA polymerase II-binding domain. RRM_1 PF00076.22 EGD92642.1 - 0.19 11.6 0.1 0.36 10.7 0.1 1.5 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TFIIA PF03153.13 EGD92642.1 - 0.69 9.9 17.1 1 9.3 17.1 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit GET2 PF08690.10 EGD92642.1 - 8.6 5.9 8.5 12 5.5 7.2 1.7 1 1 1 2 2 2 0 GET complex subunit GET2 FAM176 PF14851.6 EGD92643.1 - 0.0038 16.9 2.1 0.0044 16.7 2.1 1.1 1 0 0 1 1 1 1 FAM176 family ORC6 PF05460.13 EGD92643.1 - 0.0071 15.7 2.6 0.0076 15.6 2.6 1.0 1 0 0 1 1 1 1 Origin recognition complex subunit 6 (ORC6) Connexin PF00029.19 EGD92643.1 - 0.02 14.7 0.3 0.02 14.6 0.3 1.1 1 0 0 1 1 1 0 Connexin DUF3405 PF11885.8 EGD92643.1 - 0.04 12.5 1.8 0.049 12.2 1.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3405) RNA_pol_Rpc4 PF05132.14 EGD92643.1 - 0.043 14.2 0.4 0.048 14.1 0.4 1.1 1 0 0 1 1 1 0 RNA polymerase III RPC4 Ferlin_C PF16165.5 EGD92643.1 - 0.085 12.8 4.0 0.098 12.6 4.0 1.1 1 0 0 1 1 1 0 Ferlin C-terminus OATP PF03137.20 EGD92643.1 - 0.1 10.9 0.7 0.11 10.7 0.7 1.0 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family PEX11 PF05648.14 EGD92643.1 - 0.11 11.9 0.7 0.13 11.7 0.7 1.1 1 0 0 1 1 1 0 Peroxisomal biogenesis factor 11 (PEX11) CSG2 PF16965.5 EGD92643.1 - 0.12 11.3 0.1 0.12 11.2 0.1 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator Cnd2 PF05786.14 EGD92643.1 - 0.14 10.8 5.7 0.16 10.6 5.7 1.0 1 0 0 1 1 1 0 Condensin complex subunit 2 CLN3 PF02487.17 EGD92643.1 - 0.18 10.8 0.1 0.18 10.8 0.1 1.0 1 0 0 1 1 1 0 CLN3 protein EIIBC-GUT_N PF03612.14 EGD92643.1 - 0.21 11.3 1.1 0.25 11.0 1.1 1.1 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus CDC45 PF02724.14 EGD92643.1 - 0.31 9.3 5.5 0.3 9.3 5.5 1.0 1 0 0 1 1 1 0 CDC45-like protein DUF3899 PF13038.6 EGD92643.1 - 0.38 11.3 2.0 0.58 10.7 2.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3899) Presenilin PF01080.17 EGD92643.1 - 0.47 9.2 1.1 0.48 9.1 1.1 1.1 1 0 0 1 1 1 0 Presenilin Pap_E4 PF02711.14 EGD92643.1 - 0.48 11.4 3.7 0.63 11.0 3.7 1.2 1 0 0 1 1 1 0 E4 protein DUF3464 PF11947.8 EGD92643.1 - 1.2 8.8 3.9 1.4 8.7 3.9 1.1 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 DUF3682 PF12446.8 EGD92643.1 - 1.8 9.1 6.7 2.4 8.6 6.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3682) RuvC_III PF18541.1 EGD92643.1 - 3.6 7.5 0.0 3.6 7.5 0.0 2.0 1 1 1 2 2 2 0 RuvC endonuclease subdomain 3 RNA_polI_A34 PF08208.11 EGD92643.1 - 4.9 7.2 15.3 6.6 6.8 15.3 1.1 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 E1-E2_ATPase PF00122.20 EGD92645.1 - 4.4e-48 163.2 5.0 4.4e-48 163.2 5.0 2.5 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase_N PF00690.26 EGD92645.1 - 1.8e-11 43.6 0.0 4e-11 42.5 0.0 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase PF00702.26 EGD92645.1 - 1.9e-10 41.4 0.2 1.8e-08 34.9 0.0 2.5 1 1 1 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 EGD92645.1 - 0.0027 17.5 1.6 0.004 16.9 0.1 1.9 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase DUF4392 PF14336.6 EGD92645.1 - 0.075 12.5 0.0 0.14 11.6 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4392) Glycos_transf_1 PF00534.20 EGD92646.1 - 2e-20 73.0 0.0 3.9e-20 72.1 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 EGD92646.1 - 6.6e-13 49.2 0.0 1.1e-12 48.5 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.6 EGD92646.1 - 0.00028 21.2 0.0 0.00088 19.6 0.0 1.7 2 0 0 2 2 2 1 Glycosyl transferases group 1 DUF3632 PF12311.8 EGD92649.1 - 2.4e-44 151.8 10.5 3.1e-44 151.5 10.5 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3632) RNA_pol_Rpb2_6 PF00562.28 EGD92650.1 - 3.2e-124 414.9 0.0 5.5e-124 414.2 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 EGD92650.1 - 6.5e-56 189.1 0.4 9.7e-56 188.5 0.4 1.3 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_7 PF04560.20 EGD92650.1 - 5.5e-31 106.8 0.4 1.3e-30 105.6 0.4 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_2 PF04561.14 EGD92650.1 - 8.7e-30 103.8 1.9 3.7e-29 101.7 1.6 2.1 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_4 PF04566.13 EGD92650.1 - 4.4e-26 90.9 0.6 1.3e-25 89.4 0.6 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_3 PF04565.16 EGD92650.1 - 3.2e-18 65.6 0.0 7.7e-18 64.4 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_5 PF04567.17 EGD92650.1 - 1.9e-11 44.4 0.5 7e-11 42.5 0.5 2.1 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 Ribosomal_L22e PF01776.17 EGD92650.1 - 0.18 12.2 0.9 1.1 9.7 0.0 2.4 2 0 0 2 2 2 0 Ribosomal L22e protein family PUF PF00806.19 EGD92652.1 - 9.1e-57 185.7 8.4 1.3e-07 30.9 0.0 9.0 9 0 0 9 9 9 8 Pumilio-family RNA binding repeat LolA_2 PF16584.5 EGD92652.1 - 0.11 12.4 0.0 0.24 11.3 0.0 1.5 1 0 0 1 1 1 0 Outer membrane lipoprotein carrier protein LolA ORC5_C PF14630.6 EGD92653.1 - 1e-77 261.5 0.0 1.4e-77 261.1 0.0 1.2 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 5 C-terminus AAA_16 PF13191.6 EGD92653.1 - 5.1e-20 72.5 0.0 1e-19 71.6 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain NACHT PF05729.12 EGD92653.1 - 1.3e-06 28.5 0.0 0.015 15.2 0.0 2.5 2 0 0 2 2 2 2 NACHT domain T2SSE PF00437.20 EGD92653.1 - 0.00076 18.6 0.0 0.0012 18.0 0.0 1.2 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_22 PF13401.6 EGD92653.1 - 0.0017 18.7 0.0 0.0041 17.4 0.0 1.7 1 1 0 1 1 1 1 AAA domain KAP_NTPase PF07693.14 EGD92653.1 - 0.0055 16.0 0.0 0.0077 15.5 0.0 1.3 1 0 0 1 1 1 1 KAP family P-loop domain ABC_tran PF00005.27 EGD92653.1 - 0.009 16.5 0.0 0.018 15.5 0.0 1.5 1 0 0 1 1 1 1 ABC transporter AAA_30 PF13604.6 EGD92653.1 - 0.01 15.5 0.0 0.018 14.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 EGD92653.1 - 0.011 16.3 0.0 0.018 15.6 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 EGD92653.1 - 0.011 15.4 0.0 0.031 14.0 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain FtsK_SpoIIIE PF01580.18 EGD92653.1 - 0.013 14.9 0.0 0.022 14.1 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_33 PF13671.6 EGD92653.1 - 0.018 15.2 0.0 0.038 14.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.6 EGD92653.1 - 0.033 14.2 0.0 0.063 13.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 EGD92653.1 - 0.069 12.7 0.0 0.59 9.6 0.0 2.0 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_27 PF13514.6 EGD92653.1 - 0.088 12.4 0.2 7.6 6.1 0.0 2.5 3 0 0 3 3 2 0 AAA domain cobW PF02492.19 EGD92653.1 - 0.1 12.2 0.0 0.15 11.6 0.0 1.2 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain RNA_helicase PF00910.22 EGD92653.1 - 0.11 12.9 0.0 0.21 12.0 0.0 1.4 1 0 0 1 1 1 0 RNA helicase NB-ARC PF00931.22 EGD92653.1 - 0.13 11.5 0.0 0.21 10.7 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain Zeta_toxin PF06414.12 EGD92653.1 - 0.14 11.4 0.0 0.22 10.8 0.0 1.2 1 0 0 1 1 1 0 Zeta toxin SMC_N PF02463.19 EGD92653.1 - 0.15 11.5 0.0 0.27 10.6 0.0 1.3 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain ATPase_2 PF01637.18 EGD92653.1 - 0.18 11.7 0.0 0.27 11.1 0.0 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA PF00004.29 EGD92653.1 - 0.21 12.0 0.1 0.53 10.7 0.1 1.8 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Guanylate_kin PF00625.21 EGD92653.1 - 0.22 11.2 0.0 0.39 10.4 0.0 1.4 1 0 0 1 1 1 0 Guanylate kinase ATP_bind_1 PF03029.17 EGD92653.1 - 0.25 11.1 0.0 0.38 10.5 0.0 1.3 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein Septin PF00735.18 EGD92653.1 - 0.28 10.4 0.0 0.59 9.4 0.0 1.6 2 0 0 2 2 1 0 Septin Mak10 PF04112.13 EGD92654.1 - 1.2e-43 148.5 0.0 2.5e-43 147.5 0.0 1.5 1 0 0 1 1 1 1 Mak10 subunit, NatC N(alpha)-terminal acetyltransferase ATP-synt_Eps PF04627.13 EGD92655.1 - 2.7e-21 75.3 0.3 3.5e-21 74.9 0.3 1.2 1 0 0 1 1 1 1 Mitochondrial ATP synthase epsilon chain Myb_DNA-binding PF00249.31 EGD92656.1 - 0.02 15.1 0.0 0.039 14.1 0.0 1.5 1 0 0 1 1 1 0 Myb-like DNA-binding domain HTH_AsnC-type PF13404.6 EGD92656.1 - 0.036 13.9 0.0 0.076 12.9 0.0 1.6 1 0 0 1 1 1 0 AsnC-type helix-turn-helix domain Cpn60_TCP1 PF00118.24 EGD92657.1 - 4.9e-86 289.3 10.5 7.3e-86 288.7 10.5 1.2 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family CHASE6_C PF17150.4 EGD92657.1 - 0.18 12.5 0.0 21 5.9 0.0 2.7 2 0 0 2 2 2 0 C-terminal domain of two-partite extracellular sensor domain Cofilin_ADF PF00241.20 EGD92658.1 - 6.6e-34 116.3 0.0 7.5e-34 116.1 0.0 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein Galanin PF01296.18 EGD92659.1 - 0.16 12.0 0.9 1.6 8.8 0.0 2.3 2 0 0 2 2 2 0 Galanin COX4 PF02936.14 EGD92660.1 - 1.3e-45 154.8 0.3 1.8e-45 154.3 0.3 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase subunit IV DUF3106 PF11304.8 EGD92660.1 - 0.017 15.6 2.7 0.017 15.6 2.7 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3106) DUF1138 PF06592.13 EGD92660.1 - 0.11 12.6 0.0 0.33 11.0 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1138) DUF1104 PF06518.11 EGD92660.1 - 0.14 12.5 0.3 0.14 12.5 0.3 1.8 2 1 0 2 2 2 0 Protein of unknown function (DUF1104) Alpha-amylase_C PF02806.18 EGD92661.1 - 2.9e-25 88.6 0.1 7.7e-25 87.2 0.1 1.7 1 0 0 1 1 1 1 Alpha amylase, C-terminal all-beta domain CBM_48 PF02922.18 EGD92661.1 - 6.6e-19 68.1 0.0 2.1e-18 66.4 0.0 1.9 1 0 0 1 1 1 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) Alpha-amylase PF00128.24 EGD92661.1 - 1e-11 45.0 0.4 3.3e-11 43.3 0.5 1.7 2 0 0 2 2 2 1 Alpha amylase, catalytic domain ATP-synt_ab PF00006.25 EGD92662.1 - 7e-48 163.1 0.1 3.2e-46 157.7 0.1 2.3 1 1 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 EGD92662.1 - 3.2e-21 75.6 3.1 9.5e-21 74.1 2.6 2.1 2 0 0 2 2 2 1 ATP synthase alpha/beta family, beta-barrel domain AAA PF00004.29 EGD92662.1 - 0.004 17.6 0.1 0.18 12.2 0.0 2.4 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) RsgA_GTPase PF03193.16 EGD92662.1 - 0.0098 15.8 0.5 0.029 14.3 0.0 2.0 3 0 0 3 3 3 1 RsgA GTPase NB-ARC PF00931.22 EGD92662.1 - 0.017 14.3 0.2 0.093 11.9 0.1 2.0 2 0 0 2 2 2 0 NB-ARC domain AAA_19 PF13245.6 EGD92662.1 - 0.032 14.6 1.0 0.47 10.8 0.2 2.4 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 EGD92662.1 - 0.041 13.8 0.4 0.12 12.3 0.0 2.0 3 0 0 3 3 3 0 NACHT domain ATPase PF06745.13 EGD92662.1 - 0.045 13.1 0.1 0.082 12.2 0.1 1.4 1 0 0 1 1 1 0 KaiC T3SS_ATPase_C PF18269.1 EGD92662.1 - 0.052 13.4 0.8 0.26 11.2 0.8 2.1 1 1 0 1 1 1 0 T3SS EscN ATPase C-terminal domain RNA_helicase PF00910.22 EGD92662.1 - 0.081 13.3 0.0 0.17 12.2 0.0 1.6 1 0 0 1 1 1 0 RNA helicase AAA_22 PF13401.6 EGD92662.1 - 0.15 12.4 0.0 0.85 9.9 0.0 2.1 2 0 0 2 2 2 0 AAA domain ATPase_2 PF01637.18 EGD92662.1 - 0.22 11.4 0.2 0.66 9.8 0.0 1.8 2 1 0 2 2 2 0 ATPase domain predominantly from Archaea FAD_binding_4 PF01565.23 EGD92664.1 - 1.9e-18 66.5 0.3 3.7e-18 65.6 0.3 1.5 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EGD92664.1 - 2.4e-10 40.4 0.2 5.6e-10 39.2 0.2 1.7 1 0 0 1 1 1 1 Berberine and berberine like AAA_2 PF07724.14 EGD92667.1 - 3.6e-38 131.4 0.0 4.1e-37 127.9 0.0 2.3 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA PF00004.29 EGD92667.1 - 1.2e-14 54.9 0.0 2.5e-14 53.8 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ClpB_D2-small PF10431.9 EGD92667.1 - 2.8e-09 36.9 0.3 9.1e-09 35.3 0.0 1.9 2 0 0 2 2 2 1 C-terminal, D2-small domain, of ClpB protein AAA_5 PF07728.14 EGD92667.1 - 1.6e-06 28.1 0.0 3.8e-06 27.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 EGD92667.1 - 0.00017 21.0 0.1 0.0077 15.6 0.0 2.9 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.26 EGD92667.1 - 0.00034 20.4 0.0 0.096 12.4 0.0 2.4 2 0 0 2 2 2 1 Sigma-54 interaction domain MCM PF00493.23 EGD92667.1 - 0.0026 16.9 0.4 0.0066 15.6 0.1 1.8 2 0 0 2 2 2 1 MCM P-loop domain AAA_16 PF13191.6 EGD92667.1 - 0.0029 18.0 0.1 0.012 16.1 0.1 2.0 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EGD92667.1 - 0.0039 17.5 0.3 0.033 14.5 0.3 2.3 1 1 0 1 1 1 1 AAA domain AAA_24 PF13479.6 EGD92667.1 - 0.0041 16.9 0.0 0.0073 16.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.12 EGD92667.1 - 0.0049 16.6 0.2 0.074 12.8 0.0 2.4 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain IstB_IS21 PF01695.17 EGD92667.1 - 0.0051 16.6 0.0 0.013 15.3 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_7 PF12775.7 EGD92667.1 - 0.041 13.4 0.0 0.075 12.6 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_18 PF13238.6 EGD92667.1 - 0.051 14.1 0.2 0.22 12.1 0.0 2.2 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 EGD92667.1 - 0.052 13.9 0.0 0.11 12.9 0.0 1.5 1 0 0 1 1 1 0 RNA helicase ABC_tran PF00005.27 EGD92667.1 - 0.069 13.7 0.0 0.15 12.6 0.0 1.6 1 0 0 1 1 1 0 ABC transporter AAA_33 PF13671.6 EGD92667.1 - 0.074 13.2 0.6 1.7 8.8 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_14 PF13173.6 EGD92667.1 - 0.086 12.9 0.0 0.2 11.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_3 PF07726.11 EGD92667.1 - 0.093 12.6 0.0 0.24 11.3 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) TsaE PF02367.17 EGD92667.1 - 0.15 12.0 0.0 0.3 11.1 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Chromo PF00385.24 EGD92668.1 - 1.3e-08 34.6 0.1 3.8e-08 33.1 0.1 1.9 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Mtf2_C PF14061.6 EGD92668.1 - 0.0081 16.3 0.0 0.02 15.0 0.0 1.7 1 0 0 1 1 1 1 Polycomb-like MTF2 factor 2 Ras PF00071.22 EGD92669.1 - 3.9e-63 211.9 0.2 4.6e-63 211.6 0.2 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EGD92669.1 - 3e-35 121.1 0.2 4.2e-35 120.6 0.2 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EGD92669.1 - 2e-13 50.1 0.1 2.6e-13 49.8 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EGD92669.1 - 1.2e-07 31.7 0.1 2e-07 31.1 0.1 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EGD92669.1 - 0.00016 21.6 1.3 0.017 15.0 0.2 2.2 1 1 0 2 2 2 1 RsgA GTPase GTP_EFTU PF00009.27 EGD92669.1 - 0.00021 20.9 0.1 0.00091 18.8 0.1 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EGD92669.1 - 0.00055 19.4 0.1 0.00088 18.7 0.1 1.4 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_22 PF13401.6 EGD92669.1 - 0.0017 18.7 0.1 0.013 15.8 0.0 2.2 2 1 0 2 2 2 1 AAA domain SRPRB PF09439.10 EGD92669.1 - 0.0077 15.7 0.0 0.013 14.9 0.0 1.4 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_14 PF13173.6 EGD92669.1 - 0.014 15.4 0.1 0.048 13.7 0.1 1.9 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EGD92669.1 - 0.014 15.7 0.1 0.026 14.9 0.1 1.6 1 1 0 1 1 1 0 AAA ATPase domain ABC_tran PF00005.27 EGD92669.1 - 0.017 15.6 0.1 0.025 15.1 0.1 1.5 1 1 0 1 1 1 0 ABC transporter AAA_24 PF13479.6 EGD92669.1 - 0.024 14.4 0.1 0.061 13.0 0.1 1.8 1 1 0 1 1 1 0 AAA domain TniB PF05621.11 EGD92669.1 - 0.035 13.5 0.0 0.17 11.3 0.0 1.9 2 0 0 2 2 2 0 Bacterial TniB protein SpoIIID PF12116.8 EGD92669.1 - 0.038 14.1 0.1 0.81 9.8 0.0 2.2 2 0 0 2 2 2 0 Stage III sporulation protein D MCM PF00493.23 EGD92669.1 - 0.091 11.8 0.0 0.22 10.6 0.0 1.7 1 1 0 1 1 1 0 MCM P-loop domain AAA_21 PF13304.6 EGD92669.1 - 0.097 12.5 0.9 0.13 12.0 0.9 1.7 1 1 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_7 PF12775.7 EGD92669.1 - 0.1 12.1 0.0 0.18 11.3 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region FeoB_N PF02421.18 EGD92669.1 - 0.11 12.0 0.1 0.29 10.7 0.0 1.6 2 0 0 2 2 2 0 Ferrous iron transport protein B F-box-like PF12937.7 EGD92670.1 - 1.1e-07 31.7 0.3 8.5e-07 28.8 0.2 2.2 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 EGD92670.1 - 0.0022 17.9 0.1 0.008 16.0 0.1 2.0 1 0 0 1 1 1 1 F-box domain Brix PF04427.18 EGD92671.1 - 6.1e-32 111.3 0.0 8.5e-32 110.8 0.0 1.2 1 0 0 1 1 1 1 Brix domain Elongin_A PF06881.11 EGD92671.1 - 0.022 15.2 0.0 0.053 14.0 0.0 1.7 1 0 0 1 1 1 0 RNA polymerase II transcription factor SIII (Elongin) subunit A BUD22 PF09073.10 EGD92671.1 - 0.044 13.1 12.3 0.014 14.7 7.6 2.0 2 0 0 2 2 2 0 BUD22 Nop14 PF04147.12 EGD92671.1 - 0.089 11.0 8.7 0.15 10.2 8.7 1.3 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.14 EGD92671.1 - 0.26 9.5 5.0 0.46 8.7 5.0 1.4 1 0 0 1 1 1 0 CDC45-like protein DNA_pol_phi PF04931.13 EGD92671.1 - 0.47 8.5 16.6 0.65 8.0 16.6 1.2 1 0 0 1 1 1 0 DNA polymerase phi RRN3 PF05327.11 EGD92671.1 - 0.54 8.7 3.8 0.77 8.2 3.8 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 TRAP_alpha PF03896.16 EGD92671.1 - 3.7 6.7 7.3 7 5.8 7.3 1.4 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit WW PF00397.26 EGD92672.1 - 3.3e-10 39.9 2.5 7.4e-10 38.8 2.5 1.7 1 0 0 1 1 1 1 WW domain DUF3623 PF12291.8 EGD92674.1 - 0.012 14.8 1.8 0.02 14.1 1.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3623) Abp2 PF09441.10 EGD92675.1 - 4.2e-86 287.3 0.1 8.1e-86 286.4 0.1 1.4 1 0 0 1 1 1 1 ARS binding protein 2 ORC6 PF05460.13 EGD92676.1 - 0.052 12.8 4.8 0.069 12.4 4.8 1.2 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) TMEM171 PF15471.6 EGD92678.1 - 1 8.3 7.2 1.3 7.9 7.2 1.3 1 0 0 1 1 1 0 Transmembrane protein family 171 4F5 PF04419.14 EGD92679.1 - 1.7 9.6 7.0 0.39 11.6 1.5 2.5 1 1 1 2 2 2 0 4F5 protein family Glycophorin_A PF01102.18 EGD92681.1 - 0.0025 18.0 0.5 0.0077 16.5 0.5 1.8 1 1 0 1 1 1 1 Glycophorin A DUF3246 PF11596.8 EGD92683.1 - 0.077 12.4 4.8 0.1 12.0 4.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3246) ORC6 PF05460.13 EGD92683.1 - 4.6 6.4 10.9 10 5.3 11.4 1.4 1 1 1 2 2 2 0 Origin recognition complex subunit 6 (ORC6) DUF829 PF05705.14 EGD92684.1 - 3.5e-48 164.6 0.0 4e-48 164.4 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF829) ODR4-like PF14778.6 EGD92684.1 - 0.13 11.1 0.0 0.2 10.6 0.0 1.1 1 0 0 1 1 1 0 Olfactory receptor 4-like UFD1 PF03152.14 EGD92685.1 - 1.6e-75 252.3 0.0 2.2e-75 251.9 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 CDC48_2 PF02933.17 EGD92685.1 - 0.05 13.4 0.0 0.81 9.5 0.0 2.2 1 1 1 2 2 2 0 Cell division protein 48 (CDC48), domain 2 GYF PF02213.16 EGD92686.1 - 4.6e-08 32.6 1.0 1.1e-07 31.4 1.0 1.7 1 0 0 1 1 1 1 GYF domain TIP49 PF06068.13 EGD92687.1 - 4.9e-153 509.4 1.4 4.9e-153 509.4 1.4 1.4 2 0 0 2 2 2 1 TIP49 P-loop domain TIP49_C PF17856.1 EGD92687.1 - 7.7e-21 74.0 0.5 3.2e-20 72.0 0.1 2.3 3 0 0 3 3 3 1 TIP49 AAA-lid domain AAA PF00004.29 EGD92687.1 - 6.7e-08 33.0 0.1 9e-05 22.9 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 EGD92687.1 - 2e-07 30.9 0.5 0.0002 21.1 0.1 2.6 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EGD92687.1 - 2.2e-05 24.9 0.1 6.2e-05 23.5 0.1 1.9 1 1 0 1 1 1 1 AAA ATPase domain DnaB_C PF03796.15 EGD92687.1 - 5e-05 22.8 0.6 9e-05 21.9 0.6 1.3 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain Mg_chelatase PF01078.21 EGD92687.1 - 0.0021 17.5 0.8 0.027 13.9 0.3 2.2 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 EGD92687.1 - 0.0083 16.1 0.1 0.62 10.1 0.0 2.8 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EGD92687.1 - 0.015 15.6 0.0 0.99 9.7 0.0 2.4 1 1 1 2 2 2 0 AAA domain Sigma54_activat PF00158.26 EGD92687.1 - 0.026 14.2 0.0 8.8 6.0 0.0 2.4 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_19 PF13245.6 EGD92687.1 - 0.051 13.9 1.6 1.8 8.9 1.6 2.4 1 1 0 1 1 1 0 AAA domain AAA_25 PF13481.6 EGD92687.1 - 0.054 13.1 0.1 0.1 12.2 0.1 1.4 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 EGD92687.1 - 0.062 13.5 0.1 0.27 11.4 0.0 2.1 2 0 0 2 2 2 0 AAA domain Parvo_NS1 PF01057.17 EGD92687.1 - 0.09 11.8 0.0 0.14 11.2 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_7 PF12775.7 EGD92687.1 - 0.12 11.9 0.2 0.49 9.9 0.0 2.0 2 0 0 2 2 2 0 P-loop containing dynein motor region HSBP1 PF06825.12 EGD92688.1 - 3.7e-06 26.7 2.4 0.096 12.6 0.0 5.4 5 0 0 5 5 4 1 Heat shock factor binding protein 1 DUF1664 PF07889.12 EGD92688.1 - 0.00086 19.3 21.5 0.14 12.2 0.6 5.2 4 3 0 4 4 4 1 Protein of unknown function (DUF1664) GAS PF13851.6 EGD92688.1 - 0.0014 18.0 0.2 0.0014 18.0 0.2 5.2 3 1 2 5 5 5 1 Growth-arrest specific micro-tubule binding Baculo_PEP_C PF04513.12 EGD92688.1 - 0.0036 17.3 31.4 0.41 10.7 1.8 5.7 3 2 1 5 5 5 2 Baculovirus polyhedron envelope protein, PEP, C terminus Cortex-I_coil PF09304.10 EGD92688.1 - 0.041 14.1 33.4 0.043 14.0 1.2 6.4 3 2 3 7 7 7 0 Cortexillin I, coiled coil FlaC_arch PF05377.11 EGD92688.1 - 0.1 13.0 21.9 0.78 10.2 0.9 7.0 7 2 1 8 8 8 0 Flagella accessory protein C (FlaC) MbeD_MobD PF04899.12 EGD92688.1 - 0.11 12.6 11.8 0.37 10.9 0.0 4.8 3 1 1 4 4 4 0 MbeD/MobD like MtrB PF05440.12 EGD92688.1 - 0.14 12.6 1.7 40 4.7 0.0 4.5 4 2 1 5 5 5 0 Tetrahydromethanopterin S-methyltransferase subunit B Flavodoxin_3 PF12641.7 EGD92688.1 - 0.25 11.0 2.4 1 9.0 0.0 2.9 3 1 0 3 3 3 0 Flavodoxin domain PRD PF00874.20 EGD92688.1 - 0.31 11.4 2.6 30 5.0 0.2 3.3 2 1 0 2 2 2 0 PRD domain YvrJ PF12841.7 EGD92688.1 - 0.49 10.0 3.2 91 2.7 0.0 4.5 4 0 0 4 4 4 0 YvrJ protein family DUF948 PF06103.11 EGD92688.1 - 0.55 10.5 24.9 3.7 7.9 0.5 7.1 3 1 1 6 6 6 0 Bacterial protein of unknown function (DUF948) BLOC1_2 PF10046.9 EGD92688.1 - 1.3 9.3 26.4 0.12 12.7 1.5 7.1 4 2 3 8 8 8 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 CENP-F_leu_zip PF10473.9 EGD92688.1 - 1.4 8.9 35.7 0.54 10.3 0.8 5.1 2 1 1 5 5 5 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 COG2 PF06148.11 EGD92688.1 - 1.7 8.7 19.6 2.9 8.0 0.5 5.4 2 2 2 5 5 5 0 COG (conserved oligomeric Golgi) complex component, COG2 Bacillus_HBL PF05791.11 EGD92688.1 - 1.9 8.2 32.0 0.52 10.1 4.8 4.9 3 2 2 5 5 5 0 Bacillus haemolytic enterotoxin (HBL) DUF4407 PF14362.6 EGD92688.1 - 2.4 7.4 34.6 32 3.7 14.9 4.4 1 1 2 3 3 3 0 Domain of unknown function (DUF4407) GAIN_A PF18619.1 EGD92688.1 - 2.5 8.4 5.9 8.7 6.6 0.9 3.5 2 0 0 2 2 2 0 GPCR-Autoproteolysis-INducing (GAIN) subdomain A KIP1 PF07765.12 EGD92688.1 - 4 7.6 6.1 7.5 6.8 0.3 4.1 2 1 3 5 5 5 0 KIP1-like protein TMPIT PF07851.13 EGD92688.1 - 4.5 6.4 31.2 0.44 9.8 0.4 4.7 2 1 3 5 5 4 0 TMPIT-like protein HrpB7 PF09486.10 EGD92688.1 - 5.7 7.3 21.2 0.024 15.0 4.6 3.9 4 1 0 4 4 4 0 Bacterial type III secretion protein (HrpB7) ISG65-75 PF11727.8 EGD92688.1 - 6.1 6.0 22.3 0.22 10.7 0.7 3.1 3 1 0 3 3 3 0 Invariant surface glycoprotein Syntaxin-6_N PF09177.11 EGD92688.1 - 7.2 7.2 29.8 1.5 9.5 0.9 6.1 2 2 2 5 5 5 0 Syntaxin 6, N-terminal ApoLp-III PF07464.11 EGD92688.1 - 7.8 6.6 33.3 0.63 10.1 8.1 5.2 3 2 2 5 5 5 0 Apolipophorin-III precursor (apoLp-III) HIP1_clath_bdg PF16515.5 EGD92688.1 - 8.1 7.1 35.8 0.08 13.6 7.7 5.3 4 2 1 5 5 5 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Phasin PF05597.11 EGD92688.1 - 9.3 6.3 23.2 1.5 8.8 1.2 5.2 4 2 1 5 5 5 0 Poly(hydroxyalcanoate) granule associated protein (phasin) DUF4254 PF14063.6 EGD92688.1 - 9.8 6.0 12.4 2.2 8.1 0.4 4.3 3 1 1 4 4 4 0 Protein of unknown function (DUF4254) FSH1 PF03959.13 EGD92689.1 - 5.4e-29 101.4 0.0 7.3e-29 101.0 0.0 1.1 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_2 PF02230.16 EGD92689.1 - 0.029 14.2 0.4 1.1 9.0 0.2 2.6 2 1 0 2 2 2 0 Phospholipase/Carboxylesterase Methyltransf_25 PF13649.6 EGD92690.1 - 5.7e-14 52.6 0.0 1.2e-13 51.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EGD92690.1 - 7.9e-10 39.3 0.0 1.4e-09 38.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EGD92690.1 - 1.5e-08 34.7 0.0 2.1e-08 34.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EGD92690.1 - 3e-08 33.6 0.0 4e-08 33.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EGD92690.1 - 5.8e-08 33.4 0.0 1.3e-07 32.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain TehB PF03848.14 EGD92690.1 - 0.0016 17.9 0.0 0.0024 17.3 0.0 1.3 1 0 0 1 1 1 1 Tellurite resistance protein TehB Ubie_methyltran PF01209.18 EGD92690.1 - 0.0059 16.0 0.0 0.0082 15.5 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_20 PF12147.8 EGD92690.1 - 0.016 14.4 0.0 0.02 14.1 0.0 1.1 1 0 0 1 1 1 0 Putative methyltransferase Methyltransf_16 PF10294.9 EGD92690.1 - 0.022 14.5 0.0 0.032 14.0 0.0 1.3 1 0 0 1 1 1 0 Lysine methyltransferase MTS PF05175.14 EGD92690.1 - 0.026 14.1 0.0 0.041 13.4 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain NodS PF05401.11 EGD92690.1 - 0.059 13.0 0.0 0.11 12.1 0.0 1.4 1 1 0 1 1 1 0 Nodulation protein S (NodS) Peptidase_M14 PF00246.24 EGD92691.1 - 1.1e-80 271.6 0.0 9.2e-80 268.5 0.0 1.9 2 0 0 2 2 2 1 Zinc carboxypeptidase Propep_M14 PF02244.16 EGD92691.1 - 8.6e-11 42.1 0.7 1.8e-10 41.0 0.1 1.9 2 0 0 2 2 2 1 Carboxypeptidase activation peptide Thioredoxin PF00085.20 EGD92692.1 - 0.00095 19.1 0.0 0.0019 18.2 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin Osteopontin PF00865.18 EGD92692.1 - 0.5 9.8 18.0 0.29 10.6 6.6 2.2 2 0 0 2 2 2 0 Osteopontin SMI1_KNR4 PF09346.10 EGD92693.1 - 1e-33 116.6 0.0 1.9e-33 115.7 0.0 1.5 1 0 0 1 1 1 1 SMI1 / KNR4 family (SUKH-1) PNRC PF15365.6 EGD92694.1 - 1e-08 34.8 7.7 1e-08 34.8 7.7 4.6 5 0 0 5 5 5 1 Proline-rich nuclear receptor coactivator motif zf-rbx1 PF12678.7 EGD92695.1 - 5.5e-25 87.4 12.5 7.7e-25 86.9 12.5 1.2 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 EGD92695.1 - 3.5e-17 62.2 10.0 4.6e-17 61.9 10.0 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_2 PF13639.6 EGD92695.1 - 2.4e-06 27.8 14.7 8e-05 22.9 14.7 2.2 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EGD92695.1 - 5e-05 23.1 3.3 5e-05 23.1 3.3 2.3 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EGD92695.1 - 0.0025 17.6 11.7 0.045 13.6 11.7 2.4 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) FANCL_C PF11793.8 EGD92695.1 - 0.11 12.7 8.9 0.56 10.4 9.0 1.9 1 1 1 2 2 2 0 FANCL C-terminal domain zf-C3HC4_3 PF13920.6 EGD92695.1 - 0.41 10.5 10.8 0.83 9.6 4.4 2.5 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EGD92695.1 - 0.6 10.2 8.2 2.2 8.4 8.2 2.0 1 1 0 1 1 1 0 RING-type zinc-finger Zn_ribbon_17 PF17120.5 EGD92695.1 - 0.69 9.6 14.3 1e+02 2.6 14.3 2.3 1 1 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-RING_11 PF17123.5 EGD92695.1 - 1.1 9.0 17.1 1e+02 2.8 17.1 2.5 1 1 0 1 1 1 0 RING-like zinc finger SPC12 PF06645.13 EGD92696.1 - 4.5e-26 90.7 1.4 5.6e-26 90.4 1.4 1.1 1 0 0 1 1 1 1 Microsomal signal peptidase 12 kDa subunit (SPC12) MFS_1 PF07690.16 EGD92697.1 - 2.3e-30 105.8 35.7 2.3e-30 105.8 35.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EGD92697.1 - 8.4e-15 54.6 8.6 1.3e-14 53.9 8.6 1.3 1 0 0 1 1 1 1 Sugar (and other) transporter YqcI_YcgG PF08892.11 EGD92698.1 - 1.2e-66 224.5 0.1 1.6e-66 224.2 0.1 1.2 1 0 0 1 1 1 1 YqcI/YcgG family CorA PF01544.18 EGD92699.1 - 3.7e-43 147.9 0.0 4.9e-43 147.5 0.0 1.1 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein Mid1 PF12929.7 EGD92700.1 - 2.8e-154 514.4 3.4 3.3e-154 514.2 3.4 1.0 1 0 0 1 1 1 1 Stretch-activated Ca2+-permeable channel component Fz PF01392.22 EGD92700.1 - 0.00025 21.7 7.2 0.014 16.0 3.0 2.5 2 0 0 2 2 2 2 Fz domain Es2 PF09751.9 EGD92701.1 - 1.6e-140 469.7 17.1 2e-140 469.4 17.1 1.1 1 0 0 1 1 1 1 Nuclear protein Es2 Zn_clus PF00172.18 EGD92705.1 - 2.2e-06 27.7 10.3 3.6e-06 27.0 10.3 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SGL PF08450.12 EGD92706.1 - 8e-27 94.4 0.7 7.5e-25 87.9 0.7 2.4 1 1 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region Str_synth PF03088.16 EGD92706.1 - 0.0041 17.2 0.0 0.096 12.8 0.0 3.0 2 1 0 2 2 2 1 Strictosidine synthase Arylesterase PF01731.20 EGD92706.1 - 0.13 12.5 0.0 0.67 10.2 0.0 2.1 2 0 0 2 2 2 0 Arylesterase TPR_2 PF07719.17 EGD92707.1 - 1.6e-24 83.9 22.1 0.0071 16.4 0.1 12.4 11 0 0 11 11 11 7 Tetratricopeptide repeat TPR_1 PF00515.28 EGD92707.1 - 1.2e-22 78.7 23.6 0.0013 18.5 0.1 11.6 11 0 0 11 11 11 7 Tetratricopeptide repeat TPR_19 PF14559.6 EGD92707.1 - 2.8e-15 56.6 37.7 0.00021 21.7 0.0 10.2 9 3 1 10 10 10 5 Tetratricopeptide repeat TPR_8 PF13181.6 EGD92707.1 - 2.1e-14 52.5 24.6 0.049 13.9 0.2 11.5 13 0 0 13 13 12 4 Tetratricopeptide repeat TPR_14 PF13428.6 EGD92707.1 - 3.2e-13 49.3 36.2 0.0044 17.7 0.3 12.5 12 1 0 13 13 12 4 Tetratricopeptide repeat TPR_12 PF13424.6 EGD92707.1 - 1.8e-08 34.6 33.2 0.0073 16.6 3.7 9.3 7 3 3 10 10 10 5 Tetratricopeptide repeat TPR_16 PF13432.6 EGD92707.1 - 4.7e-08 33.5 27.2 0.084 13.5 0.5 8.7 9 0 0 9 9 8 3 Tetratricopeptide repeat TPR_6 PF13174.6 EGD92707.1 - 1.6e-06 28.4 32.4 0.0093 16.6 0.2 12.9 15 0 0 15 15 15 1 Tetratricopeptide repeat TPR_17 PF13431.6 EGD92707.1 - 2.3e-05 24.5 22.5 0.14 12.6 0.1 10.2 12 0 0 12 12 12 1 Tetratricopeptide repeat TPR_7 PF13176.6 EGD92707.1 - 0.0078 16.2 28.5 0.49 10.5 0.0 8.9 10 0 0 10 10 8 2 Tetratricopeptide repeat TPR_11 PF13414.6 EGD92707.1 - 0.013 15.2 26.6 0.05 13.3 0.4 8.6 9 1 1 10 10 10 0 TPR repeat TPR_4 PF07721.14 EGD92707.1 - 0.12 13.1 3.7 27 5.8 0.0 4.7 3 0 0 3 3 3 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EGD92707.1 - 0.29 11.2 7.7 5.3 7.2 0.1 4.3 4 0 0 4 4 4 0 Fis1 C-terminal tetratricopeptide repeat Acyltransferase PF01553.21 EGD92708.1 - 1.4e-27 96.0 0.0 2.2e-27 95.3 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase Acyltransf_C PF16076.5 EGD92708.1 - 9e-14 51.3 0.1 1.7e-13 50.4 0.1 1.5 1 0 0 1 1 1 1 Acyltransferase C-terminus NAD_kinase PF01513.21 EGD92709.1 - 1.6e-48 165.4 0.1 2.5e-48 164.8 0.1 1.2 1 0 0 1 1 1 1 ATP-NAD kinase DAGK_cat PF00781.24 EGD92709.1 - 0.013 15.1 0.0 0.022 14.4 0.0 1.4 1 0 0 1 1 1 0 Diacylglycerol kinase catalytic domain Myticin-prepro PF10690.9 EGD92710.1 - 0.17 12.2 0.3 0.3 11.4 0.3 1.4 1 0 0 1 1 1 0 Myticin pre-proprotein from the mussel Pkinase PF00069.25 EGD92711.1 - 3.8e-67 226.4 0.2 4.1e-66 223.0 0.2 2.2 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD92711.1 - 1.5e-50 171.9 0.0 3e-50 170.9 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.28 EGD92711.1 - 4.5e-24 84.6 0.0 4.5e-24 84.6 0.0 2.6 3 0 0 3 3 3 1 P21-Rho-binding domain Kinase-like PF14531.6 EGD92711.1 - 1.8e-05 24.3 0.0 3.1e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EGD92711.1 - 2e-05 23.5 0.0 2e-05 23.5 0.0 2.1 3 1 0 3 3 3 1 Fungal protein kinase Haspin_kinase PF12330.8 EGD92711.1 - 4e-05 22.7 0.0 8e-05 21.7 0.0 1.4 1 0 0 1 1 1 1 Haspin like kinase domain KIND PF16474.5 EGD92711.1 - 0.027 14.4 0.0 0.062 13.2 0.0 1.6 1 0 0 1 1 1 0 Kinase non-catalytic C-lobe domain Seadorna_VP7 PF07387.11 EGD92711.1 - 0.033 13.2 0.1 0.056 12.5 0.1 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 APH PF01636.23 EGD92711.1 - 0.92 9.4 6.0 1 9.2 0.4 2.9 2 1 1 3 3 3 0 Phosphotransferase enzyme family HGTP_anticodon PF03129.20 EGD92713.1 - 1.2e-19 70.3 2.6 4.2e-19 68.5 0.0 3.0 3 0 0 3 3 3 1 Anticodon binding domain tRNA-synt_2b PF00587.25 EGD92713.1 - 5e-09 36.4 0.0 7.7e-08 32.5 0.0 2.4 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Brix PF04427.18 EGD92714.1 - 6.8e-23 81.8 0.0 1e-22 81.2 0.0 1.3 1 0 0 1 1 1 1 Brix domain Sporozoite_P67 PF05642.11 EGD92714.1 - 0.83 7.7 4.8 1.1 7.2 4.8 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Nop14 PF04147.12 EGD92714.1 - 3.3 5.8 18.9 4.3 5.4 18.9 1.1 1 0 0 1 1 1 0 Nop14-like family SRI PF08236.11 EGD92716.1 - 9.3e-21 73.8 15.2 3.1e-20 72.1 15.2 2.0 1 0 0 1 1 1 1 SRI (Set2 Rpb1 interacting) domain SET PF00856.28 EGD92716.1 - 1.1e-17 64.9 0.4 1.1e-17 64.9 0.4 3.3 3 1 0 3 3 3 1 SET domain AWS PF17907.1 EGD92716.1 - 1.6e-10 40.9 11.9 1.6e-10 40.9 11.9 2.7 2 0 0 2 2 2 1 AWS domain Med26 PF08711.11 EGD92716.1 - 1.1e-05 25.4 0.2 3.2e-05 23.8 0.2 1.8 1 0 0 1 1 1 1 TFIIS helical bundle-like domain WW PF00397.26 EGD92716.1 - 0.033 14.3 0.3 0.089 12.9 0.3 1.8 1 0 0 1 1 1 0 WW domain PHA_synth_III_E PF09712.10 EGD92716.1 - 0.13 11.4 0.4 0.22 10.6 0.4 1.3 1 0 0 1 1 1 0 Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E) Pox_H7 PF04787.12 EGD92716.1 - 0.34 11.4 4.8 0.71 10.4 4.8 1.5 1 0 0 1 1 1 0 Late protein H7 Baculo_PEP_C PF04513.12 EGD92718.1 - 5.2e-06 26.5 9.4 0.00028 20.9 1.6 2.0 1 1 1 2 2 2 2 Baculovirus polyhedron envelope protein, PEP, C terminus Spc7 PF08317.11 EGD92718.1 - 3.1e-05 23.0 0.9 3.8e-05 22.7 0.9 1.1 1 0 0 1 1 1 1 Spc7 kinetochore protein EzrA PF06160.12 EGD92718.1 - 3.5e-05 22.2 0.5 0.00011 20.5 0.8 1.6 2 0 0 2 2 2 1 Septation ring formation regulator, EzrA Transcrip_act PF04949.13 EGD92718.1 - 0.00013 21.9 0.1 0.014 15.3 0.0 2.1 1 1 1 2 2 2 1 Transcriptional activator Mer2 PF09074.10 EGD92718.1 - 0.0015 18.4 0.5 0.0022 17.8 0.5 1.2 1 0 0 1 1 1 1 Mer2 DUF677 PF05055.12 EGD92718.1 - 0.0033 16.4 0.4 0.0042 16.0 0.4 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF677) TelA PF05816.11 EGD92718.1 - 0.0034 16.5 2.3 0.54 9.3 0.1 2.3 1 1 1 2 2 2 2 Toxic anion resistance protein (TelA) RasGAP_C PF03836.15 EGD92718.1 - 0.005 17.0 2.0 1.9 8.6 1.1 2.6 1 1 2 3 3 3 1 RasGAP C-terminus Effector_1 PF04518.12 EGD92718.1 - 0.0061 15.7 0.5 0.014 14.5 0.3 1.6 1 1 1 2 2 2 1 Effector from type III secretion system NPV_P10 PF05531.12 EGD92718.1 - 0.0066 16.9 4.3 0.018 15.5 2.4 2.6 2 1 0 2 2 1 1 Nucleopolyhedrovirus P10 protein 7TMR-HDED PF07697.11 EGD92718.1 - 0.0073 16.5 0.5 0.0098 16.0 0.5 1.1 1 0 0 1 1 1 1 7TM-HD extracellular Filament PF00038.21 EGD92718.1 - 0.0079 15.8 0.9 0.011 15.3 0.9 1.1 1 0 0 1 1 1 1 Intermediate filament protein ISG65-75 PF11727.8 EGD92718.1 - 0.0092 15.2 2.0 0.013 14.8 1.7 1.3 1 1 0 1 1 1 1 Invariant surface glycoprotein ApoLp-III PF07464.11 EGD92718.1 - 0.0094 16.1 3.6 0.016 15.3 3.6 1.4 1 1 0 1 1 1 1 Apolipophorin-III precursor (apoLp-III) Serine_rich PF08824.10 EGD92718.1 - 0.01 15.9 0.5 0.036 14.1 0.5 1.8 1 1 0 1 1 1 0 Serine rich protein interaction domain TACC_C PF05010.14 EGD92718.1 - 0.01 15.6 0.7 0.044 13.6 0.8 1.6 1 1 0 1 1 1 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal Syntaxin PF00804.25 EGD92718.1 - 0.012 15.3 3.3 0.019 14.6 2.4 1.6 2 0 0 2 2 2 0 Syntaxin FlaC_arch PF05377.11 EGD92718.1 - 0.012 16.0 3.1 0.9 10.0 0.0 3.1 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) MAP65_ASE1 PF03999.12 EGD92718.1 - 0.012 14.3 0.3 0.016 14.0 0.3 1.0 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) CdvA PF18822.1 EGD92718.1 - 0.013 15.3 2.1 0.053 13.4 0.3 2.4 2 1 1 3 3 2 0 CdvA-like coiled-coil domain DUF812 PF05667.11 EGD92718.1 - 0.014 14.3 0.1 0.016 14.1 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF812) IFT57 PF10498.9 EGD92718.1 - 0.015 14.3 1.1 0.019 14.0 1.1 1.1 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 CLZ PF16526.5 EGD92718.1 - 0.016 15.6 1.2 0.24 11.8 0.1 2.4 1 1 1 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Fib_alpha PF08702.10 EGD92718.1 - 0.019 15.2 3.5 0.027 14.6 3.1 1.4 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family BLOC1_2 PF10046.9 EGD92718.1 - 0.02 15.2 1.2 0.76 10.1 0.5 2.2 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 APG17 PF04108.12 EGD92718.1 - 0.021 14.0 1.1 0.97 8.5 0.8 1.9 1 1 1 2 2 2 0 Autophagy protein Apg17 Rab5-bind PF09311.11 EGD92718.1 - 0.021 14.2 1.3 0.028 13.8 1.3 1.1 1 0 0 1 1 1 0 Rabaptin-like protein Cortex-I_coil PF09304.10 EGD92718.1 - 0.024 14.8 0.7 0.044 14.0 0.6 1.5 1 1 0 1 1 1 0 Cortexillin I, coiled coil SHE3 PF17078.5 EGD92718.1 - 0.025 14.3 1.9 0.041 13.6 1.8 1.3 1 1 0 1 1 1 0 SWI5-dependent HO expression protein 3 DegS PF05384.11 EGD92718.1 - 0.036 13.6 0.1 0.049 13.1 0.1 1.2 1 0 0 1 1 1 0 Sensor protein DegS CorA PF01544.18 EGD92718.1 - 0.04 13.2 0.1 0.058 12.7 0.1 1.3 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein Apolipoprotein PF01442.18 EGD92718.1 - 0.041 13.7 0.3 0.066 13.1 0.3 1.3 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain DUF1640 PF07798.11 EGD92718.1 - 0.041 13.9 1.0 0.064 13.3 1.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1640) GAS PF13851.6 EGD92718.1 - 0.044 13.1 0.3 0.066 12.6 0.3 1.2 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Prefoldin_2 PF01920.20 EGD92718.1 - 0.045 13.7 1.9 1.4 8.9 1.8 2.3 1 1 0 1 1 1 0 Prefoldin subunit Atg14 PF10186.9 EGD92718.1 - 0.047 12.8 0.9 0.06 12.4 0.9 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF1664 PF07889.12 EGD92718.1 - 0.063 13.3 4.8 2.1 8.4 0.6 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) VasL PF12486.8 EGD92718.1 - 0.065 13.1 0.4 0.21 11.4 0.2 1.9 2 0 0 2 2 2 0 Type VI secretion system, EvfB, or VasL DUF3206 PF11472.8 EGD92718.1 - 0.077 13.0 0.1 0.11 12.5 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3206) HIP1_clath_bdg PF16515.5 EGD92718.1 - 0.083 13.5 0.9 0.27 11.9 0.2 2.0 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 FlgN PF05130.12 EGD92718.1 - 0.098 13.2 1.1 0.35 11.4 1.0 2.0 1 1 0 1 1 1 0 FlgN protein Uso1_p115_C PF04871.13 EGD92718.1 - 0.11 12.9 0.7 0.17 12.2 0.7 1.3 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region TPR_MLP1_2 PF07926.12 EGD92718.1 - 0.11 12.6 1.1 0.31 11.1 0.9 1.7 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein Spectrin PF00435.21 EGD92718.1 - 0.11 13.0 1.5 6.1 7.4 0.1 2.4 1 1 1 2 2 2 0 Spectrin repeat Laminin_II PF06009.12 EGD92718.1 - 0.15 12.0 3.7 0.5 10.4 2.5 2.0 1 1 1 2 2 2 0 Laminin Domain II DUF948 PF06103.11 EGD92718.1 - 0.19 12.0 3.2 1.7 8.9 0.5 2.8 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) DUF16 PF01519.16 EGD92718.1 - 0.23 11.9 3.4 1.2 9.7 1.6 2.2 1 1 1 2 2 2 0 Protein of unknown function DUF16 PspA_IM30 PF04012.12 EGD92718.1 - 0.27 10.8 1.6 0.75 9.3 0.7 1.8 1 1 1 2 2 2 0 PspA/IM30 family YkyA PF10368.9 EGD92718.1 - 0.27 10.9 2.6 0.65 9.6 2.7 1.7 1 1 0 1 1 1 0 Putative cell-wall binding lipoprotein AT_hook PF02178.19 EGD92722.1 - 0.016 15.0 1.5 0.077 12.9 1.5 2.2 1 0 0 1 1 1 0 AT hook motif BAR PF03114.18 EGD92723.1 - 6.6e-47 160.2 2.6 1.3e-46 159.2 2.6 1.4 1 1 0 1 1 1 1 BAR domain CP12 PF02672.15 EGD92723.1 - 0.012 16.3 0.5 0.051 14.3 0.0 2.3 3 1 0 3 3 3 0 CP12 domain Pkinase PF00069.25 EGD92725.1 - 4e-50 170.6 0.0 5.7e-50 170.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD92725.1 - 4e-27 95.1 0.0 5.4e-27 94.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EGD92725.1 - 0.009 15.4 0.0 0.017 14.5 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EGD92725.1 - 0.019 14.3 0.0 0.027 13.8 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Sybindin PF04099.12 EGD92726.1 - 6.3e-25 87.8 0.0 7.9e-25 87.5 0.0 1.1 1 0 0 1 1 1 1 Sybindin-like family Sedlin_N PF04628.13 EGD92726.1 - 0.0037 17.4 0.2 0.0051 16.9 0.2 1.2 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region Pkinase PF00069.25 EGD92727.1 - 9.6e-57 192.3 0.0 6.2e-51 173.3 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EGD92727.1 - 4.8e-35 121.1 0.0 3.3e-33 115.1 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 EGD92727.1 - 9e-09 35.0 0.0 4.3e-07 29.5 0.0 2.2 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 EGD92727.1 - 0.0011 19.0 0.0 0.0043 17.0 0.0 1.9 2 0 0 2 2 2 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EGD92727.1 - 0.0023 16.8 0.0 0.011 14.5 0.0 1.9 2 0 0 2 2 2 1 Fungal protein kinase Pept_tRNA_hydro PF01195.19 EGD92728.1 - 3.7e-23 82.3 0.0 3.5e-20 72.6 0.0 2.8 1 1 0 1 1 1 1 Peptidyl-tRNA hydrolase DUF2263 PF10021.9 EGD92729.1 - 0.016 15.5 0.2 0.2 12.0 0.2 2.3 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2263) Methyltransf_23 PF13489.6 EGD92730.1 - 1.3e-10 41.3 0.0 2.8e-10 40.3 0.0 1.6 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EGD92730.1 - 9.1e-08 32.7 0.0 2.2e-07 31.5 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EGD92730.1 - 9.7e-06 25.5 0.0 4.9e-05 23.2 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EGD92730.1 - 2.9e-05 24.7 0.0 0.00027 21.6 0.0 2.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EGD92730.1 - 0.0025 18.4 0.0 0.0049 17.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_2 PF00891.18 EGD92730.1 - 0.0066 15.8 0.0 0.011 15.0 0.0 1.4 1 0 0 1 1 1 1 O-methyltransferase domain MTS PF05175.14 EGD92730.1 - 0.013 15.1 0.0 0.05 13.1 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase small domain FtsJ PF01728.19 EGD92730.1 - 0.013 15.6 0.0 0.22 11.6 0.0 2.1 2 0 0 2 2 2 0 FtsJ-like methyltransferase Methyltransf_4 PF02390.17 EGD92730.1 - 0.026 14.0 0.0 0.069 12.6 0.0 1.6 2 0 0 2 2 2 0 Putative methyltransferase DUF938 PF06080.12 EGD92730.1 - 0.074 12.8 0.0 0.12 12.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF938) TP6A_N PF04406.14 EGD92731.1 - 9.5e-15 54.3 0.0 1.7e-14 53.5 0.0 1.4 1 0 0 1 1 1 1 Type IIB DNA topoisomerase UQ_con PF00179.26 EGD92732.1 - 1.3e-48 164.2 0.0 1.5e-48 164.1 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Scramblase PF03803.15 EGD92733.1 - 9.2e-56 188.6 0.0 3.2e-54 183.6 0.0 2.7 1 1 0 1 1 1 1 Scramblase Ribosomal_L27 PF01016.19 EGD92735.1 - 8.1e-32 109.1 1.1 1.4e-31 108.4 1.1 1.4 1 0 0 1 1 1 1 Ribosomal L27 protein Rad9_Rad53_bind PF08605.10 EGD92736.1 - 8.6e-17 61.5 0.0 1.6e-16 60.6 0.0 1.4 1 0 0 1 1 1 1 Fungal Rad9-like Rad53-binding Tudor_3 PF18115.1 EGD92736.1 - 2e-16 59.5 0.0 4.2e-16 58.5 0.0 1.6 1 0 0 1 1 1 1 DNA repair protein Crb2 Tudor domain BRCT PF00533.26 EGD92736.1 - 6.2e-08 32.9 0.0 1.8e-07 31.4 0.0 1.9 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 EGD92736.1 - 4.2e-07 30.3 0.0 9.1e-07 29.2 0.0 1.6 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain RTT107_BRCT_5 PF16770.5 EGD92736.1 - 3.3e-05 23.7 0.1 0.00025 20.9 0.0 2.3 2 0 0 2 2 2 1 Regulator of Ty1 transposition protein 107 BRCT domain BRCT_3 PF18428.1 EGD92736.1 - 0.099 12.7 0.0 0.31 11.2 0.0 1.8 1 0 0 1 1 1 0 BRCA1 C Terminus (BRCT) domain Anillin_N PF16018.5 EGD92736.1 - 0.91 10.2 6.8 6.6 7.4 0.2 4.5 3 1 1 4 4 4 0 Anillin N-terminus tRNA_int_endo PF01974.17 EGD92737.1 - 1.4e-17 63.6 0.4 4e-17 62.1 0.5 1.7 1 1 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain tRNA_int_endo_N PF02778.14 EGD92737.1 - 0.0013 18.4 0.0 0.05 13.3 0.0 2.3 2 0 0 2 2 2 1 tRNA intron endonuclease, N-terminal domain Nop10p PF04135.12 EGD92738.1 - 5.2e-22 77.6 0.6 6.2e-22 77.4 0.6 1.1 1 0 0 1 1 1 1 Nucleolar RNA-binding protein, Nop10p family NOB1_Zn_bind PF08772.11 EGD92739.1 - 5.8e-33 112.9 3.2 1.2e-32 111.8 3.2 1.6 1 0 0 1 1 1 1 Nin one binding (NOB1) Zn-ribbon like PIN_6 PF17146.4 EGD92739.1 - 2.4e-30 104.8 0.3 1.8e-29 102.0 0.1 2.5 3 0 0 3 3 3 1 PIN domain of ribonuclease HypA PF01155.19 EGD92739.1 - 0.0041 17.1 0.2 0.15 12.1 0.2 2.3 2 0 0 2 2 2 1 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-NADH-PPase PF09297.11 EGD92739.1 - 0.0061 16.2 0.6 0.0061 16.2 0.6 2.3 2 0 0 2 2 2 1 NADH pyrophosphatase zinc ribbon domain zinc_ribbon_15 PF17032.5 EGD92739.1 - 0.054 14.2 0.2 0.12 13.1 0.2 1.6 1 0 0 1 1 1 0 zinc-ribbon family SDA1 PF05285.12 EGD92739.1 - 0.081 12.3 6.6 0.0091 15.5 2.6 1.4 2 0 0 2 2 2 0 SDA1 SWIRM-assoc_2 PF16496.5 EGD92739.1 - 0.26 10.1 8.0 0.4 9.5 8.0 1.3 1 0 0 1 1 1 0 SWIRM-associated domain at the N-terminal Zn-ribbon_8 PF09723.10 EGD92739.1 - 0.32 11.2 5.5 0.19 11.9 1.4 2.3 2 0 0 2 2 2 0 Zinc ribbon domain Peptidase_M18 PF02127.15 EGD92740.1 - 2.6e-133 445.0 0.0 3e-133 444.8 0.0 1.0 1 0 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) ABC_tran PF00005.27 EGD92741.1 - 6e-51 172.5 0.0 1.7e-25 90.1 0.0 2.6 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 EGD92741.1 - 6.8e-23 81.9 1.1 0.00012 22.0 0.0 4.3 2 2 1 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system ABC2_membrane_3 PF12698.7 EGD92741.1 - 1e-21 77.5 44.6 2.1e-13 50.1 24.0 2.5 2 0 0 2 2 2 2 ABC-2 family transporter protein SMC_N PF02463.19 EGD92741.1 - 8.7e-10 38.4 1.1 0.004 16.6 0.0 3.8 2 2 1 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EGD92741.1 - 2.8e-09 36.6 1.7 6.9e-05 22.5 0.4 2.8 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_23 PF13476.6 EGD92741.1 - 9.1e-08 32.8 2.9 0.007 16.9 0.2 2.4 2 0 0 2 2 2 2 AAA domain AAA_27 PF13514.6 EGD92741.1 - 6.8e-06 25.8 0.4 0.099 12.2 0.0 2.3 2 0 0 2 2 2 2 AAA domain RsgA_GTPase PF03193.16 EGD92741.1 - 1.8e-05 24.7 0.2 0.058 13.3 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase AAA_15 PF13175.6 EGD92741.1 - 4.7e-05 23.3 0.0 0.026 14.2 0.1 3.3 3 0 0 3 3 3 1 AAA ATPase domain DUF4162 PF13732.6 EGD92741.1 - 0.00029 21.5 0.0 0.012 16.3 0.0 3.0 3 0 0 3 3 3 1 Domain of unknown function (DUF4162) AAA_16 PF13191.6 EGD92741.1 - 0.00058 20.3 0.0 1.2 9.5 0.0 2.6 2 0 0 2 2 2 2 AAA ATPase domain AAA_30 PF13604.6 EGD92741.1 - 0.0008 19.2 0.9 0.42 10.3 0.2 2.8 3 0 0 3 3 2 2 AAA domain SbcCD_C PF13558.6 EGD92741.1 - 0.0054 16.9 0.1 8 6.8 0.1 4.0 3 2 0 3 3 3 1 Putative exonuclease SbcCD, C subunit AAA_28 PF13521.6 EGD92741.1 - 0.017 15.3 0.1 1.5 9.1 0.1 2.4 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 EGD92741.1 - 0.023 14.3 0.7 2.9 7.4 0.1 2.7 2 0 0 2 2 2 0 AAA domain SRP54 PF00448.22 EGD92741.1 - 0.047 13.3 0.5 8.4 6.0 0.2 2.4 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain MMR_HSR1 PF01926.23 EGD92741.1 - 0.061 13.4 0.6 4 7.5 0.0 2.5 2 0 0 2 2 2 0 50S ribosome-binding GTPase Zeta_toxin PF06414.12 EGD92741.1 - 0.082 12.2 0.3 11 5.3 0.1 2.6 3 0 0 3 3 3 0 Zeta toxin AAA_22 PF13401.6 EGD92741.1 - 0.19 12.0 0.2 25 5.1 0.1 2.7 2 0 0 2 2 2 0 AAA domain AAA_13 PF13166.6 EGD92741.1 - 0.26 9.9 0.7 6.2 5.3 0.0 2.5 3 0 0 3 3 3 0 AAA domain MFS_1 PF07690.16 EGD92743.1 - 9.5e-36 123.4 23.7 3.7e-35 121.5 23.3 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily ABC2_membrane PF01061.24 EGD92744.1 - 7.2e-80 267.3 54.7 4.9e-41 140.5 12.0 2.9 3 0 0 3 3 3 2 ABC-2 type transporter ABC_tran PF00005.27 EGD92744.1 - 1.5e-33 116.2 0.0 1e-16 61.7 0.0 2.5 2 0 0 2 2 2 2 ABC transporter PDR_CDR PF06422.12 EGD92744.1 - 8.1e-23 80.1 7.0 2.5e-20 72.2 0.0 3.2 3 0 0 3 3 2 2 CDR ABC transporter ABC_trans_N PF14510.6 EGD92744.1 - 2.4e-11 44.1 0.0 1.2e-10 41.9 0.0 2.3 1 0 0 1 1 1 1 ABC-transporter N-terminal AAA_21 PF13304.6 EGD92744.1 - 1.3e-05 25.2 0.0 0.16 11.8 0.0 2.5 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 EGD92744.1 - 2.8e-05 24.6 0.1 0.015 15.6 0.1 2.5 2 0 0 2 2 2 1 AAA ATPase domain AAA_33 PF13671.6 EGD92744.1 - 4.3e-05 23.7 0.2 0.0015 18.7 0.0 2.8 3 0 0 3 3 2 1 AAA domain AAA_18 PF13238.6 EGD92744.1 - 0.00015 22.3 0.0 0.0038 17.8 0.0 2.5 2 0 0 2 2 2 1 AAA domain ABC2_membrane_3 PF12698.7 EGD92744.1 - 0.0012 18.0 49.8 0.0027 16.9 24.0 3.6 2 1 1 3 3 3 2 ABC-2 family transporter protein RsgA_GTPase PF03193.16 EGD92744.1 - 0.0016 18.4 0.0 0.0036 17.2 0.0 1.5 1 0 0 1 1 1 1 RsgA GTPase AAA_25 PF13481.6 EGD92744.1 - 0.0016 18.1 0.1 0.019 14.6 0.1 2.4 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 EGD92744.1 - 0.0021 17.7 0.4 0.016 15.0 0.2 2.3 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_28 PF13521.6 EGD92744.1 - 0.0051 17.1 0.1 0.12 12.7 0.1 2.4 2 0 0 2 2 2 1 AAA domain SMC_N PF02463.19 EGD92744.1 - 0.017 14.6 0.0 0.73 9.2 0.0 2.5 3 0 0 3 3 3 0 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 EGD92744.1 - 0.062 13.6 0.2 0.41 10.9 0.2 2.5 2 1 0 2 2 2 0 AAA domain AAA_17 PF13207.6 EGD92744.1 - 0.067 13.6 0.1 0.31 11.5 0.0 2.1 2 0 0 2 2 2 0 AAA domain cobW PF02492.19 EGD92744.1 - 0.078 12.6 0.4 0.17 11.5 0.4 1.5 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain ATP-grasp_5 PF13549.6 EGD92744.1 - 0.17 11.3 0.0 0.34 10.3 0.0 1.4 1 0 0 1 1 1 0 ATP-grasp domain PRK PF00485.18 EGD92744.1 - 0.21 11.3 0.1 27 4.4 0.0 2.4 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family AAA_23 PF13476.6 EGD92744.1 - 0.36 11.3 0.0 0.36 11.3 0.0 2.0 2 0 0 2 2 1 0 AAA domain Adap_comp_sub PF00928.21 EGD92747.1 - 5.9e-91 304.5 0.0 9.2e-91 303.9 0.0 1.3 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 EGD92747.1 - 1.4e-09 38.0 0.1 2.4e-09 37.3 0.1 1.3 1 0 0 1 1 1 1 Clathrin adaptor complex small chain muHD PF10291.9 EGD92747.1 - 0.1 12.0 0.0 0.29 10.5 0.0 1.7 2 0 0 2 2 2 0 Muniscin C-terminal mu homology domain Ribonucleas_3_3 PF14622.6 EGD92748.1 - 1.8e-27 96.0 0.0 2.9e-27 95.3 0.0 1.3 1 0 0 1 1 1 1 Ribonuclease-III-like Ribonuclease_3 PF00636.26 EGD92748.1 - 4.7e-06 27.2 0.0 9.5e-06 26.2 0.0 1.5 1 0 0 1 1 1 1 Ribonuclease III domain Sdh_cyt PF01127.22 EGD92750.1 - 7.2e-24 84.1 3.9 9.5e-24 83.7 3.9 1.1 1 0 0 1 1 1 1 Succinate dehydrogenase/Fumarate reductase transmembrane subunit NMO PF03060.15 EGD92751.1 - 5.9e-52 177.1 0.2 6.5e-51 173.7 0.2 1.9 1 1 0 1 1 1 1 Nitronate monooxygenase IMPDH PF00478.25 EGD92751.1 - 1.1e-08 34.5 0.0 5.6e-07 28.9 0.0 2.2 1 1 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain FMN_dh PF01070.18 EGD92751.1 - 0.001 18.2 0.2 0.0018 17.4 0.2 1.4 1 0 0 1 1 1 1 FMN-dependent dehydrogenase NanE PF04131.14 EGD92751.1 - 0.018 14.3 0.3 0.047 12.9 0.1 1.8 2 1 0 2 2 2 0 Putative N-acetylmannosamine-6-phosphate epimerase SCP1201-deam PF14428.6 EGD92752.1 - 0.008 16.1 0.1 0.008 16.1 0.1 2.3 3 0 0 3 3 3 1 SCP1.201-like deaminase Hydrophobin PF01185.18 EGD92753.1 - 1.9e-07 31.6 10.9 2.6e-07 31.2 10.9 1.2 1 0 0 1 1 1 1 Fungal hydrophobin WW PF00397.26 EGD92754.1 - 3.6e-10 39.8 2.0 3.6e-10 39.8 2.0 2.3 2 0 0 2 2 2 1 WW domain WRW PF10206.9 EGD92754.1 - 0.094 13.1 0.1 0.21 11.9 0.1 1.5 1 0 0 1 1 1 0 Mitochondrial F1F0-ATP synthase, subunit f Ank_2 PF12796.7 EGD92755.1 - 5.5e-13 49.3 0.8 7.3e-12 45.7 0.7 2.4 2 1 0 2 2 2 1 Ankyrin repeats (3 copies) Ank PF00023.30 EGD92755.1 - 4.2e-11 42.8 0.6 8.3e-07 29.2 0.2 3.4 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 EGD92755.1 - 5.8e-10 39.2 1.7 2.4e-07 30.9 0.4 3.1 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EGD92755.1 - 3.4e-09 36.2 0.3 6.4e-06 26.1 0.0 3.0 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.6 EGD92755.1 - 1.7e-08 34.8 0.2 8.1e-08 32.7 0.2 2.2 2 1 0 2 2 2 1 Ankyrin repeats (many copies) Glyco_transf_21 PF13506.6 EGD92756.1 - 1.3e-13 50.8 0.0 6.8e-07 28.9 0.0 3.3 2 1 0 2 2 2 2 Glycosyl transferase family 21 Glyco_tranf_2_3 PF13641.6 EGD92756.1 - 3.8e-07 30.2 0.0 7.4e-07 29.3 0.0 1.5 1 1 0 1 1 1 1 Glycosyltransferase like family 2 E1-E2_ATPase PF00122.20 EGD92757.1 - 5.3e-34 117.3 0.7 1.3e-33 116.1 0.7 1.7 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.26 EGD92757.1 - 2.2e-23 83.6 0.0 4.9e-11 43.3 0.0 2.7 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EGD92757.1 - 2.2e-11 43.7 0.2 7.5e-11 42.0 0.1 2.0 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 EGD92757.1 - 2.2e-08 33.7 0.0 5e-08 32.5 0.0 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 EGD92757.1 - 1.1e-05 25.4 1.1 2.3e-05 24.3 0.2 1.9 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase DUF2157 PF09925.9 EGD92757.1 - 0.0092 15.8 1.8 2.2 8.0 0.0 2.4 2 0 0 2 2 2 2 Predicted membrane protein (DUF2157) Sigma_reg_N PF13800.6 EGD92757.1 - 0.43 10.9 1.9 1.7 9.0 0.4 2.5 2 0 0 2 2 2 0 Sigma factor regulator N-terminal DUF3262 PF11660.8 EGD92757.1 - 2.7 8.4 7.8 26 5.3 2.7 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3262) Cation_ATPase_C PF00689.21 EGD92758.1 - 3.4e-33 114.9 4.6 4e-33 114.6 4.6 1.0 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus DUF4133 PF13571.6 EGD92758.1 - 0.26 11.6 2.1 0.28 11.6 0.4 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4133) HAT_KAT11 PF08214.11 EGD92759.1 - 5.3e-94 315.4 0.0 6.7e-94 315.0 0.0 1.1 1 0 0 1 1 1 1 Histone acetylation protein Cupin_2 PF07883.11 EGD92760.1 - 6.7e-07 28.9 0.0 1.2e-06 28.2 0.0 1.4 1 0 0 1 1 1 1 Cupin domain MannoseP_isomer PF01050.18 EGD92760.1 - 0.013 15.4 0.1 0.018 14.9 0.1 1.2 1 0 0 1 1 1 0 Mannose-6-phosphate isomerase Hid1 PF12722.7 EGD92762.1 - 0 1099.0 0.0 0 1098.8 0.0 1.0 1 0 0 1 1 1 1 High-temperature-induced dauer-formation protein Dymeclin PF09742.9 EGD92762.1 - 3.9e-99 332.8 0.0 4.8e-99 332.5 0.0 1.0 1 0 0 1 1 1 1 Dyggve-Melchior-Clausen syndrome protein BC10 PF06726.12 EGD92762.1 - 0.076 13.3 0.1 0.29 11.4 0.1 2.0 2 0 0 2 2 2 0 Bladder cancer-related protein BC10 CDC45 PF02724.14 EGD92764.1 - 0.59 8.4 4.4 0.69 8.1 4.4 1.0 1 0 0 1 1 1 0 CDC45-like protein Vps54 PF07928.12 EGD92766.1 - 1.3e-50 171.3 0.4 5.5e-50 169.3 0.1 2.3 2 0 0 2 2 2 1 Vps54-like protein DUF2451 PF10474.9 EGD92766.1 - 7e-09 35.8 0.1 5.2e-08 33.0 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function C-terminus (DUF2451) Vps54_N PF10475.9 EGD92766.1 - 1.9e-05 24.1 0.2 6.2e-05 22.4 0.2 1.9 1 0 0 1 1 1 1 Vacuolar-sorting protein 54, of GARP complex Cytochrom_B562 PF07361.11 EGD92766.1 - 0.057 14.1 0.4 0.2 12.3 0.4 2.0 1 0 0 1 1 1 0 Cytochrome b562 DUF4363 PF14276.6 EGD92766.1 - 0.092 12.9 0.3 2.1 8.5 0.1 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4363) Pkinase PF00069.25 EGD92768.1 - 1.5e-25 90.1 0.0 7.9e-25 87.7 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD92768.1 - 7.6e-09 35.2 0.0 0.0028 17.0 0.0 2.3 2 1 0 2 2 2 2 Protein tyrosine kinase Pkinase_fungal PF17667.1 EGD92768.1 - 0.046 12.5 0.0 0.059 12.1 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase APH PF01636.23 EGD92768.1 - 0.077 12.9 0.0 0.16 11.9 0.0 1.7 1 1 0 1 1 1 0 Phosphotransferase enzyme family MCM PF00493.23 EGD92769.1 - 6.8e-104 345.9 0.1 1.4e-103 344.9 0.1 1.5 2 0 0 2 2 2 1 MCM P-loop domain MCM_OB PF17207.3 EGD92769.1 - 5.5e-37 126.4 0.7 1.1e-36 125.5 0.7 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 EGD92769.1 - 7.4e-29 100.0 1.0 1.9e-28 98.7 1.0 1.8 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 EGD92769.1 - 2.4e-16 60.2 0.5 5.5e-16 59.0 0.5 1.6 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 EGD92769.1 - 8.9e-07 28.5 0.0 0.00014 21.3 0.0 2.3 1 1 1 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 EGD92769.1 - 2.3e-05 24.4 0.0 4.9e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 EGD92769.1 - 0.00085 19.2 0.0 0.0033 17.3 0.0 2.0 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_7 PF17867.1 EGD92769.1 - 0.0013 19.0 0.2 0.0052 17.0 0.1 2.1 2 0 0 2 2 2 1 Midasin AAA lid domain Sigma54_activat PF00158.26 EGD92769.1 - 0.023 14.4 0.1 0.26 11.0 0.1 2.3 1 1 0 1 1 1 0 Sigma-54 interaction domain ECH_1 PF00378.20 EGD92770.1 - 8.3e-36 123.6 0.1 3.1e-23 82.4 0.2 2.1 2 0 0 2 2 2 2 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EGD92770.1 - 6.6e-17 62.0 0.0 3.6e-08 33.3 0.0 2.0 2 0 0 2 2 2 2 Enoyl-CoA hydratase/isomerase PfkB PF00294.24 EGD92771.1 - 6.7e-42 143.8 0.0 1.1e-41 143.1 0.0 1.4 1 1 0 1 1 1 1 pfkB family carbohydrate kinase p6 PF17548.2 EGD92771.1 - 0.025 14.6 0.0 0.072 13.0 0.0 1.8 1 0 0 1 1 1 0 Histone-like Protein p6 PAN_1 PF00024.26 EGD92772.1 - 1.3e-07 31.5 23.2 0.00086 19.2 5.6 2.8 2 1 1 3 3 3 2 PAN domain PAN_4 PF14295.6 EGD92772.1 - 0.00095 19.0 17.4 0.0028 17.5 3.5 3.7 3 0 0 3 3 3 2 PAN domain PAN_3 PF08277.12 EGD92772.1 - 0.049 13.4 6.4 1.9 8.3 2.8 2.6 2 0 0 2 2 2 0 PAN-like domain FAP PF07174.11 EGD92773.1 - 0.72 9.3 19.9 0.71 9.3 19.9 1.1 1 0 0 1 1 1 0 Fibronectin-attachment protein (FAP) Mito_fiss_reg PF05308.11 EGD92773.1 - 9.1 6.3 8.2 11 6.0 8.2 1.2 1 0 0 1 1 1 0 Mitochondrial fission regulator 2OG-FeII_Oxy_3 PF13640.6 EGD92774.1 - 1.5e-05 25.8 0.0 3.7e-05 24.5 0.0 1.7 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 7TM_GPCR_Srw PF10324.9 EGD92775.1 - 0.095 12.0 0.9 0.12 11.6 0.9 1.1 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srw Tau95 PF09734.9 EGD92777.1 - 6.4e-40 137.2 0.6 1.5e-39 136.0 0.6 1.7 1 0 0 1 1 1 1 RNA polymerase III transcription factor (TF)IIIC subunit HTH domain Tau95_N PF17682.1 EGD92777.1 - 7.6e-39 132.8 0.0 1.6e-38 131.7 0.0 1.6 1 0 0 1 1 1 1 Tau95 Triple barrel domain RNA_pol_3_Rpc31 PF11705.8 EGD92777.1 - 0.21 11.8 10.4 0.47 10.7 10.4 1.5 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 B56 PF01603.20 EGD92778.1 - 4.9e-190 631.9 4.2 5.9e-190 631.6 4.2 1.1 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) Sec7_N PF12783.7 EGD92778.1 - 0.0021 18.0 3.1 0.83 9.6 0.1 2.4 2 0 0 2 2 2 2 Guanine nucleotide exchange factor in Golgi transport N-terminal FAT PF02259.23 EGD92779.1 - 9.1e-72 242.2 13.3 1.9e-71 241.1 13.3 1.6 1 0 0 1 1 1 1 FAT domain PI3_PI4_kinase PF00454.27 EGD92779.1 - 3.8e-35 121.9 0.1 8.9e-35 120.7 0.1 1.7 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FATC PF02260.20 EGD92779.1 - 6.8e-06 25.8 0.1 2e-05 24.3 0.1 1.9 1 0 0 1 1 1 1 FATC domain DUF2576 PF10845.8 EGD92779.1 - 0.11 12.1 0.0 0.38 10.4 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2576) Gluconate_2-dh3 PF13618.6 EGD92779.1 - 0.12 12.6 0.1 19 5.5 0.0 3.0 2 0 0 2 2 2 0 Gluconate 2-dehydrogenase subunit 3 HEAT PF02985.22 EGD92779.1 - 0.17 12.3 0.2 37 4.9 0.1 4.6 3 0 0 3 3 3 0 HEAT repeat DUF572 PF04502.13 EGD92780.1 - 1.3e-69 235.4 13.8 1.5e-69 235.2 13.8 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF572) DUF951 PF06107.11 EGD92780.1 - 0.044 13.7 0.1 3.5 7.6 0.0 2.4 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF951) Trypan_glycop PF00913.19 EGD92780.1 - 0.045 13.0 0.7 0.057 12.7 0.7 1.2 1 0 0 1 1 1 0 Trypanosome variant surface glycoprotein (A-type) HypA PF01155.19 EGD92780.1 - 0.072 13.1 0.6 2 8.5 0.1 2.3 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DNA_RNApol_7kD PF03604.13 EGD92780.1 - 0.11 12.2 2.4 7.8 6.3 0.4 2.5 2 0 0 2 2 2 0 DNA directed RNA polymerase, 7 kDa subunit zf-FCS PF06467.14 EGD92780.1 - 0.11 12.4 3.6 0.75 9.8 0.2 2.3 2 0 0 2 2 2 0 MYM-type Zinc finger with FCS sequence motif TF_Zn_Ribbon PF08271.12 EGD92780.1 - 0.52 9.9 6.0 0.88 9.1 1.3 2.5 2 0 0 2 2 2 0 TFIIB zinc-binding zinc_ribbon_2 PF13240.6 EGD92780.1 - 0.79 9.5 3.6 1.1 9.0 0.7 2.3 2 0 0 2 2 2 0 zinc-ribbon domain zf-ACC PF17848.1 EGD92780.1 - 2.2 8.4 5.5 3.4 7.8 0.8 2.6 2 0 0 2 2 2 0 Acetyl-coA carboxylase zinc finger domain Zn_ribbon_SprT PF17283.2 EGD92780.1 - 3.5 7.6 6.0 5.3 7.0 0.5 2.2 1 1 1 2 2 2 0 SprT-like zinc ribbon domain TPR_2 PF07719.17 EGD92781.1 - 2.9e-27 92.5 11.8 0.001 19.0 0.3 11.6 12 0 0 12 12 11 5 Tetratricopeptide repeat TPR_1 PF00515.28 EGD92781.1 - 1.3e-24 85.0 7.9 0.00037 20.2 0.8 10.4 11 0 0 11 11 11 6 Tetratricopeptide repeat ANAPC3 PF12895.7 EGD92781.1 - 1.8e-22 79.4 21.6 4.6e-21 74.8 1.7 5.7 5 1 0 5 5 5 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 EGD92781.1 - 1.7e-15 57.3 13.2 0.0025 18.3 0.0 7.6 7 1 1 8 8 8 4 Tetratricopeptide repeat TPR_8 PF13181.6 EGD92781.1 - 4.6e-15 54.5 10.0 0.013 15.7 0.1 8.8 10 0 0 10 10 9 3 Tetratricopeptide repeat TPR_12 PF13424.6 EGD92781.1 - 6.4e-14 52.0 25.9 4.3e-08 33.3 0.3 10.1 8 3 3 11 11 11 2 Tetratricopeptide repeat TPR_16 PF13432.6 EGD92781.1 - 6.2e-11 42.8 15.6 0.056 14.1 0.6 8.6 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_14 PF13428.6 EGD92781.1 - 4.3e-10 39.6 16.0 2 9.4 0.1 8.6 6 2 2 8 8 8 3 Tetratricopeptide repeat TPR_10 PF13374.6 EGD92781.1 - 2.7e-09 36.6 17.5 0.00012 21.8 0.1 7.3 9 0 0 9 9 8 2 Tetratricopeptide repeat TPR_6 PF13174.6 EGD92781.1 - 2.1e-06 28.0 8.2 3.1 8.6 0.1 7.6 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_11 PF13414.6 EGD92781.1 - 3.2e-06 26.7 9.8 0.38 10.5 0.1 6.9 6 1 1 7 7 7 2 TPR repeat TPR_7 PF13176.6 EGD92781.1 - 5.9e-06 25.9 22.9 0.93 9.7 0.1 9.5 10 0 0 10 10 10 2 Tetratricopeptide repeat TPR_17 PF13431.6 EGD92781.1 - 0.0017 18.6 11.3 8 7.1 0.0 7.8 8 1 1 9 9 8 2 Tetratricopeptide repeat TPR_21 PF09976.9 EGD92781.1 - 0.0063 16.2 2.3 5.7 6.6 0.1 4.7 5 0 0 5 5 5 1 Tetratricopeptide repeat-like domain SRP_TPR_like PF17004.5 EGD92781.1 - 0.011 15.7 0.2 0.95 9.5 0.0 3.5 3 0 0 3 3 3 0 Putative TPR-like repeat TPR_4 PF07721.14 EGD92781.1 - 0.59 10.9 12.4 0.22 12.2 0.4 5.7 7 0 0 7 7 5 0 Tetratricopeptide repeat Fungal_trans PF04082.18 EGD92782.1 - 1.4e-07 30.9 0.0 3.1e-07 29.7 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EGD92782.1 - 1.9e-06 27.9 12.2 3.9e-06 26.9 12.2 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DHHC PF01529.20 EGD92784.1 - 2.2e-26 92.5 3.5 2.2e-26 92.5 3.5 2.3 2 0 0 2 2 2 1 DHHC palmitoyltransferase Oxidored_q4 PF00507.19 EGD92784.1 - 9.6 6.4 9.7 0.46 10.7 3.7 1.9 2 0 0 2 2 2 0 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 Glyco_hydro_17 PF00332.18 EGD92786.1 - 1.1e-08 35.1 2.8 3.9e-05 23.4 1.1 2.2 1 1 1 2 2 2 2 Glycosyl hydrolases family 17 Presenilin PF01080.17 EGD92787.1 - 0.21 10.3 16.5 0.067 12.0 11.1 2.0 2 0 0 2 2 2 0 Presenilin SRR1 PF07985.12 EGD92788.1 - 7.1e-15 54.8 0.1 2.3e-14 53.2 0.1 1.8 1 1 0 1 1 1 1 SRR1 RRP7 PF12923.7 EGD92788.1 - 0.088 12.9 0.2 0.3 11.2 0.1 1.9 3 0 0 3 3 3 0 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain Abhydrolase_1 PF00561.20 EGD92790.1 - 4.4e-17 62.6 0.1 1.1e-15 58.1 0.1 2.1 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EGD92790.1 - 9.1e-14 52.6 4.0 1.3e-13 52.1 4.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EGD92790.1 - 2.3e-08 33.6 0.2 5.5e-08 32.4 0.3 1.6 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Chlorophyllase2 PF12740.7 EGD92790.1 - 0.0041 16.1 0.0 0.0061 15.5 0.0 1.2 1 0 0 1 1 1 1 Chlorophyllase enzyme Chlorophyllase PF07224.11 EGD92790.1 - 0.014 14.4 0.0 0.018 14.1 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase Esterase PF00756.20 EGD92790.1 - 0.053 13.2 0.1 0.15 11.6 0.1 1.7 1 1 0 1 1 1 0 Putative esterase Peptidase_S9 PF00326.21 EGD92790.1 - 0.12 11.9 0.2 0.19 11.2 0.2 1.3 1 0 0 1 1 1 0 Prolyl oligopeptidase family DDHD PF02862.17 EGD92791.1 - 0.0018 18.5 5.5 0.0018 18.5 5.5 2.8 2 1 0 2 2 1 1 DDHD domain Band_3_cyto PF07565.13 EGD92791.1 - 0.17 11.7 13.6 0.56 10.0 13.6 1.8 1 0 0 1 1 1 0 Band 3 cytoplasmic domain GNAT_acetyltr_2 PF13718.6 EGD92791.1 - 0.98 8.8 12.1 1.9 7.8 12.1 1.4 1 0 0 1 1 1 0 GNAT acetyltransferase 2 Membralin PF09746.9 EGD92791.1 - 1.6 7.7 7.2 2.6 7.0 7.2 1.2 1 0 0 1 1 1 0 Tumour-associated protein NARP1 PF12569.8 EGD92791.1 - 1.9 7.3 15.6 2.8 6.7 15.6 1.2 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Zip PF02535.22 EGD92791.1 - 2 7.5 7.0 5.7 6.0 7.0 1.8 1 0 0 1 1 1 0 ZIP Zinc transporter DUF4638 PF15472.6 EGD92791.1 - 2.4 7.8 12.6 5.8 6.6 12.6 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) SpoIIP PF07454.11 EGD92791.1 - 4.2 6.7 21.5 0.068 12.6 13.9 1.9 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) EOS1 PF12326.8 EGD92791.1 - 4.3 7.2 7.8 13 5.7 7.8 1.8 1 0 0 1 1 1 0 N-glycosylation protein Otopetrin PF03189.13 EGD92791.1 - 4.3 6.0 8.0 6.6 5.4 8.0 1.2 1 0 0 1 1 1 0 Otopetrin AUX_IAA PF02309.16 EGD92791.1 - 4.9 6.9 16.2 0.47 10.3 10.6 2.2 2 0 0 2 2 2 0 AUX/IAA family SID-1_RNA_chan PF13965.6 EGD92791.1 - 5.4 5.3 6.5 8.1 4.7 6.5 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 ALMT PF11744.8 EGD92791.1 - 6.5 5.5 13.1 12 4.6 13.1 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter MDM10 PF12519.8 EGD92791.1 - 7.7 5.3 14.0 16 4.2 14.0 1.4 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 YhhN PF07947.14 EGD92792.1 - 7.7e-44 149.5 2.4 1.3e-43 148.8 2.4 1.3 1 1 0 1 1 1 1 YhhN family MFS_1 PF07690.16 EGD92793.1 - 2.9e-45 154.7 25.8 2.9e-45 154.7 25.8 1.7 1 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EGD92793.1 - 7.4e-09 35.0 7.8 7.4e-09 35.0 7.8 2.2 2 1 0 2 2 2 1 Sugar (and other) transporter CPP1-like PF11833.8 EGD92793.1 - 0.025 14.2 3.1 0.096 12.3 3.1 2.0 1 0 0 1 1 1 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like OATP PF03137.20 EGD92793.1 - 0.054 11.8 2.1 0.072 11.4 1.2 1.6 1 1 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family eIF-5a PF01287.20 EGD92794.1 - 0.00018 21.5 0.1 0.00036 20.6 0.1 1.4 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold F-box-like_2 PF13013.6 EGD92795.1 - 0.089 12.8 0.1 0.12 12.4 0.1 1.5 1 1 0 1 1 1 0 F-box-like domain PHD PF00628.29 EGD92796.1 - 6.8e-10 38.7 1.7 6.8e-10 38.7 1.7 1.6 2 0 0 2 2 2 1 PHD-finger PHD_2 PF13831.6 EGD92796.1 - 0.0019 17.7 2.2 0.003 17.1 2.2 1.3 1 0 0 1 1 1 1 PHD-finger zf-CW PF07496.15 EGD92796.1 - 0.16 12.0 1.4 0.4 10.7 1.4 1.6 1 0 0 1 1 1 0 CW-type Zinc Finger Zip PF02535.22 EGD92797.1 - 0.18 11.0 12.6 0.24 10.6 12.6 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Macoilin PF09726.9 EGD92797.1 - 1.3 7.5 6.8 1.6 7.2 6.8 1.0 1 0 0 1 1 1 0 Macoilin family FAM76 PF16046.5 EGD92797.1 - 2.8 7.2 4.1 3.5 6.9 4.1 1.1 1 0 0 1 1 1 0 FAM76 protein NOA36 PF06524.12 EGD92797.1 - 4.2 6.6 12.2 6 6.1 12.2 1.1 1 0 0 1 1 1 0 NOA36 protein MARVEL PF01284.23 EGD92798.1 - 2.4e-10 40.6 3.5 3.7e-10 40.0 3.5 1.3 1 1 0 1 1 1 1 Membrane-associating domain DUF1752 PF08550.10 EGD92799.1 - 1.6e-10 40.6 3.5 3.5e-10 39.5 3.5 1.6 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) adh_short_C2 PF13561.6 EGD92800.1 - 4.7e-52 176.9 0.0 6.2e-52 176.5 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EGD92800.1 - 1.4e-35 122.5 0.0 2.3e-35 121.8 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EGD92800.1 - 1.3e-11 44.7 0.1 2.4e-11 43.9 0.1 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EGD92800.1 - 0.019 14.4 0.0 0.047 13.1 0.0 1.6 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EGD92800.1 - 0.028 13.8 0.0 2 7.7 0.0 2.1 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase CPSase_L_D2 PF02786.17 EGD92801.1 - 8.7e-74 247.6 0.0 1.3e-73 247.0 0.0 1.2 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_C PF02785.19 EGD92801.1 - 2.2e-36 124.3 0.0 4.8e-36 123.1 0.0 1.6 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain Biotin_carb_N PF00289.22 EGD92801.1 - 2.3e-35 121.5 0.0 5e-35 120.4 0.0 1.6 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_lipoyl PF00364.22 EGD92801.1 - 6.9e-15 54.7 3.5 7.7e-15 54.5 2.1 1.9 2 0 0 2 2 2 1 Biotin-requiring enzyme Dala_Dala_lig_C PF07478.13 EGD92801.1 - 1.9e-09 37.3 0.0 4.4e-09 36.2 0.0 1.6 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 EGD92801.1 - 2.2e-08 33.9 0.0 4.4e-08 32.9 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain Biotin_lipoyl_2 PF13533.6 EGD92801.1 - 1.3e-05 24.9 0.3 0.12 12.2 0.0 2.7 1 1 1 2 2 2 2 Biotin-lipoyl like ATP-grasp_3 PF02655.14 EGD92801.1 - 0.00048 20.2 0.0 0.001 19.1 0.0 1.6 1 0 0 1 1 1 1 ATP-grasp domain HlyD_3 PF13437.6 EGD92801.1 - 0.0017 19.0 0.2 0.86 10.3 0.0 2.8 2 0 0 2 2 2 1 HlyD family secretion protein GARS_A PF01071.19 EGD92801.1 - 0.0026 17.5 0.0 0.005 16.6 0.0 1.4 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain ATPgrasp_ST PF14397.6 EGD92801.1 - 0.0092 15.3 0.0 0.018 14.3 0.0 1.4 1 0 0 1 1 1 1 Sugar-transfer associated ATP-grasp GCV_H PF01597.19 EGD92801.1 - 0.015 15.2 0.4 0.035 14.0 0.2 1.7 2 0 0 2 2 1 0 Glycine cleavage H-protein ATP-grasp_4 PF13535.6 EGD92801.1 - 0.02 14.5 0.0 0.069 12.7 0.0 1.9 2 0 0 2 2 2 0 ATP-grasp domain HlyD_D23 PF16576.5 EGD92801.1 - 0.079 12.2 0.1 3.9 6.6 0.0 2.4 1 1 1 2 2 2 0 Barrel-sandwich domain of CusB or HlyD membrane-fusion RimK PF08443.11 EGD92801.1 - 0.18 11.4 0.0 0.53 9.9 0.0 1.7 2 0 0 2 2 2 0 RimK-like ATP-grasp domain Acyl-CoA_dh_1 PF00441.24 EGD92803.1 - 2.4e-40 138.2 0.5 4.6e-40 137.3 0.5 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 EGD92803.1 - 4.5e-35 120.7 0.1 9.9e-35 119.6 0.1 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 EGD92803.1 - 1.3e-26 92.7 0.1 2.6e-26 91.7 0.1 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 EGD92803.1 - 6.6e-16 58.8 0.0 1.2e-15 57.9 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain HpaB_N PF11794.8 EGD92803.1 - 0.00019 21.2 0.3 0.00047 19.9 0.3 1.6 1 1 0 1 1 1 1 4-hydroxyphenylacetate 3-hydroxylase N terminal Carboxyl_trans PF01039.22 EGD92804.1 - 3.3e-139 464.7 0.0 4.2e-139 464.4 0.0 1.1 1 0 0 1 1 1 1 Carboxyl transferase domain MdcE PF06833.11 EGD92804.1 - 0.031 13.8 0.0 7.4 6.0 0.0 2.4 2 0 0 2 2 2 0 Malonate decarboxylase gamma subunit (MdcE) Ras PF00071.22 EGD92805.1 - 1.7e-45 154.5 0.0 1.4e-24 86.5 0.0 2.1 2 0 0 2 2 2 2 Ras family Roc PF08477.13 EGD92805.1 - 5.9e-13 49.1 0.0 6.9e-08 32.7 0.0 2.2 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EGD92805.1 - 1.1e-06 28.2 0.0 0.0029 17.1 0.0 2.1 2 0 0 2 2 2 2 ADP-ribosylation factor family RsgA_GTPase PF03193.16 EGD92805.1 - 0.0011 19.0 0.0 1.8 8.5 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 EGD92805.1 - 0.0061 16.6 0.0 0.012 15.7 0.0 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EGD92805.1 - 0.022 14.3 0.0 0.16 11.5 0.0 2.5 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain AAA_22 PF13401.6 EGD92805.1 - 0.049 13.9 0.1 0.58 10.4 0.1 2.4 1 1 0 1 1 1 0 AAA domain AAA_7 PF12775.7 EGD92805.1 - 0.092 12.3 0.0 0.18 11.3 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region Abhydrolase_1 PF00561.20 EGD92807.1 - 4e-26 92.2 0.0 6.9e-26 91.4 0.0 1.4 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydro_lipase PF04083.16 EGD92807.1 - 5.9e-24 83.4 0.1 1.2e-23 82.4 0.1 1.6 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region FSH1 PF03959.13 EGD92807.1 - 0.00014 21.6 0.1 0.0038 16.9 0.1 2.2 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Hydrolase_4 PF12146.8 EGD92807.1 - 0.00026 20.4 0.0 0.0064 15.8 0.0 2.2 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_2 PF02230.16 EGD92807.1 - 0.036 13.9 0.1 7.6 6.3 0.0 2.5 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase Pet191_N PF10203.9 EGD92808.1 - 2.2e-27 95.1 6.7 2.8e-27 94.8 6.7 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein PET191 CX9C PF16860.5 EGD92808.1 - 0.0035 17.3 10.1 0.099 12.7 1.6 2.7 1 1 2 3 3 3 2 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, Cmc1 PF08583.10 EGD92808.1 - 0.011 15.7 4.7 1.4 9.0 0.5 2.2 2 0 0 2 2 2 0 Cytochrome c oxidase biogenesis protein Cmc1 like COBRA PF04833.15 EGD92808.1 - 0.016 15.1 0.5 0.019 14.9 0.5 1.1 1 0 0 1 1 1 0 COBRA-like protein PAN_3 PF08277.12 EGD92808.1 - 0.023 14.5 0.3 0.044 13.6 0.3 1.4 1 0 0 1 1 1 0 PAN-like domain DDOST_48kD PF03345.14 EGD92809.1 - 2.2e-158 527.4 0.0 2.6e-158 527.2 0.0 1.0 1 0 0 1 1 1 1 Oligosaccharyltransferase 48 kDa subunit beta NADHdh_A3 PF14987.6 EGD92810.1 - 0.023 15.0 0.2 0.03 14.6 0.2 1.1 1 0 0 1 1 1 0 NADH dehydrogenase 1 alpha subcomplex subunit 3 FAM76 PF16046.5 EGD92812.1 - 0.0028 17.1 5.1 0.015 14.6 0.2 2.1 1 1 1 2 2 2 1 FAM76 protein SDA1 PF05285.12 EGD92812.1 - 0.012 15.0 10.8 0.019 14.4 10.8 1.2 1 0 0 1 1 1 0 SDA1 DNA_pol_phi PF04931.13 EGD92812.1 - 0.019 13.1 10.3 0.026 12.7 10.3 1.1 1 0 0 1 1 1 0 DNA polymerase phi FAM176 PF14851.6 EGD92812.1 - 0.02 14.6 9.1 0.11 12.1 1.9 2.2 2 0 0 2 2 2 0 FAM176 family RRN3 PF05327.11 EGD92812.1 - 0.026 13.1 3.8 0.034 12.7 3.8 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Spt5_N PF11942.8 EGD92812.1 - 0.16 12.9 20.2 0.4 11.7 6.6 2.3 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal GOLD_2 PF13897.6 EGD92812.1 - 0.37 11.3 6.6 3.4 8.2 0.9 2.2 2 0 0 2 2 2 0 Golgi-dynamics membrane-trafficking Sigma70_ner PF04546.13 EGD92812.1 - 0.46 10.3 9.5 0.21 11.5 0.4 2.1 2 0 0 2 2 2 0 Sigma-70, non-essential region Pox_Ag35 PF03286.14 EGD92812.1 - 0.48 10.2 11.1 4.1 7.1 4.7 2.2 2 0 0 2 2 2 0 Pox virus Ag35 surface protein CDC45 PF02724.14 EGD92812.1 - 0.59 8.4 11.6 0.21 9.9 3.3 2.0 2 0 0 2 2 2 0 CDC45-like protein DUF4611 PF15387.6 EGD92812.1 - 0.7 10.2 15.2 0.15 12.3 3.6 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) LAT PF15234.6 EGD92812.1 - 0.94 9.2 5.9 7.1 6.3 0.1 2.2 2 0 0 2 2 2 0 Linker for activation of T-cells Presenilin PF01080.17 EGD92812.1 - 2.3 6.9 3.1 3 6.5 3.1 1.3 1 0 0 1 1 1 0 Presenilin CENP-B_dimeris PF09026.10 EGD92812.1 - 2.7 8.4 20.8 6.4 7.2 10.6 2.3 2 0 0 2 2 2 0 Centromere protein B dimerisation domain WRNPLPNID PF15017.6 EGD92812.1 - 2.9 8.8 15.5 6.4 7.7 3.0 2.4 2 0 0 2 2 2 0 Putative WW-binding domain and destruction box DUF3245 PF11595.8 EGD92812.1 - 4.8 7.7 15.7 6.1 7.3 9.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3245) GST_C_2 PF13410.6 EGD92813.1 - 7.6e-07 29.1 0.5 1.9e-06 27.8 0.2 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EGD92813.1 - 1.1e-06 28.8 0.0 1.9e-06 28.0 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EGD92813.1 - 0.0011 19.3 0.0 0.0024 18.3 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EGD92813.1 - 0.0035 17.5 0.0 0.0063 16.7 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_4 PF17172.4 EGD92813.1 - 0.016 15.9 0.0 0.036 14.8 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase N-terminal domain DUF2306 PF10067.9 EGD92816.1 - 1.5e-17 64.1 4.1 1.5e-17 64.1 4.1 2.3 2 0 0 2 2 2 1 Predicted membrane protein (DUF2306) DUF420 PF04238.12 EGD92816.1 - 0.0014 18.9 0.5 0.0014 18.9 0.5 2.1 2 1 0 2 2 2 1 Protein of unknown function (DUF420) Sugar_tr PF00083.24 EGD92817.1 - 2.6e-81 273.8 21.7 3e-81 273.6 21.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EGD92817.1 - 1.9e-28 99.4 38.4 1.9e-24 86.2 32.4 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily ABC_tran PF00005.27 EGD92819.1 - 3.9e-67 225.0 0.0 1.3e-32 113.2 0.0 2.4 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 EGD92819.1 - 4.1e-47 161.1 44.5 7.4e-21 75.0 9.3 5.1 4 1 1 5 5 5 5 ABC transporter transmembrane region SMC_N PF02463.19 EGD92819.1 - 2.4e-14 53.3 0.0 5e-05 22.8 0.0 3.5 1 1 2 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EGD92819.1 - 3.4e-07 29.9 0.0 0.0034 17.1 0.1 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain ABC_ATPase PF09818.9 EGD92819.1 - 1.2e-06 27.6 0.4 0.034 13.0 0.1 2.5 2 0 0 2 2 2 2 Predicted ATPase of the ABC class AAA_16 PF13191.6 EGD92819.1 - 3.1e-06 27.7 2.0 0.092 13.1 0.1 3.3 2 2 0 2 2 2 2 AAA ATPase domain AAA_15 PF13175.6 EGD92819.1 - 9.2e-06 25.6 0.1 0.14 11.8 0.0 2.8 2 1 0 2 2 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 EGD92819.1 - 2e-05 24.6 0.0 0.28 11.1 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase AAA_21 PF13304.6 EGD92819.1 - 0.00029 20.7 4.1 0.76 9.5 0.2 3.9 2 2 1 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 EGD92819.1 - 0.0016 18.7 2.8 1.9 8.8 0.1 3.6 2 2 0 2 2 2 2 AAA domain G-alpha PF00503.20 EGD92819.1 - 0.0019 17.5 0.0 0.93 8.6 0.0 2.2 2 0 0 2 2 2 2 G-protein alpha subunit AAA_25 PF13481.6 EGD92819.1 - 0.0023 17.6 0.0 0.52 9.9 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 EGD92819.1 - 0.0051 16.6 3.3 2.5 7.8 0.6 3.7 3 1 0 3 3 3 1 AAA domain AAA_5 PF07728.14 EGD92819.1 - 0.0064 16.5 0.1 2.2 8.2 0.0 3.5 3 0 0 3 3 3 1 AAA domain (dynein-related subfamily) SbcCD_C PF13558.6 EGD92819.1 - 0.0067 16.6 3.1 3.8 7.8 0.5 3.6 2 2 0 2 2 2 1 Putative exonuclease SbcCD, C subunit AAA_23 PF13476.6 EGD92819.1 - 0.0094 16.5 0.0 1.6 9.1 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EGD92819.1 - 0.0095 16.1 0.1 5.3 7.2 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 EGD92819.1 - 0.01 16.4 0.0 4.6 7.8 0.0 2.7 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 EGD92819.1 - 0.01 16.1 1.1 0.84 9.9 0.0 2.5 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 EGD92819.1 - 0.012 14.9 1.7 1.1 8.5 0.0 3.2 4 0 0 4 4 4 0 Zeta toxin DUF87 PF01935.17 EGD92819.1 - 0.013 15.6 0.9 0.3 11.2 0.1 2.6 2 0 0 2 2 2 0 Helicase HerA, central domain AAA_7 PF12775.7 EGD92819.1 - 0.02 14.4 0.1 6.9 6.1 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region DUF815 PF05673.13 EGD92819.1 - 0.056 12.6 0.0 3.4 6.7 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF815) PRK PF00485.18 EGD92819.1 - 0.12 12.1 0.0 11 5.7 0.0 2.3 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family RNA_helicase PF00910.22 EGD92819.1 - 0.13 12.6 0.7 9.3 6.7 0.0 2.9 3 0 0 3 3 2 0 RNA helicase Rad17 PF03215.15 EGD92819.1 - 0.16 11.9 0.1 0.9 9.4 0.0 2.2 2 0 0 2 2 2 0 Rad17 P-loop domain MMR_HSR1 PF01926.23 EGD92819.1 - 0.28 11.3 0.7 21 5.2 0.0 2.8 2 0 0 2 2 2 0 50S ribosome-binding GTPase ADH_N PF08240.12 EGD92820.1 - 8e-27 93.3 6.1 1.4e-26 92.5 6.1 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EGD92820.1 - 5.2e-14 52.3 0.0 8.3e-14 51.7 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 EGD92820.1 - 0.00041 19.8 0.1 0.00066 19.1 0.1 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ELFV_dehydrog PF00208.21 EGD92820.1 - 0.0038 17.0 0.1 0.0061 16.3 0.1 1.2 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase AlaDh_PNT_C PF01262.21 EGD92820.1 - 0.0046 16.3 0.1 0.0072 15.6 0.1 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_10 PF13460.6 EGD92820.1 - 0.13 12.2 0.0 0.19 11.6 0.0 1.2 1 0 0 1 1 1 0 NAD(P)H-binding Mito_carr PF00153.27 EGD92821.1 - 3.1e-40 136.0 8.9 4.2e-16 58.6 0.3 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Ferric_reduct PF01794.19 EGD92822.1 - 3.3e-19 69.2 13.6 3.3e-19 69.2 13.6 2.5 3 0 0 3 3 3 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.12 EGD92822.1 - 3.8e-13 49.5 0.0 9.5e-13 48.2 0.0 1.7 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_6 PF08030.12 EGD92822.1 - 5.3e-13 49.4 0.0 8.7e-13 48.7 0.0 1.4 1 0 0 1 1 1 1 Ferric reductase NAD binding domain ABC1 PF03109.16 EGD92823.1 - 3.5e-20 72.4 0.1 9.7e-20 70.9 0.0 1.9 2 0 0 2 2 2 1 ABC1 family APH PF01636.23 EGD92823.1 - 0.05 13.5 0.8 0.17 11.8 0.3 2.0 2 0 0 2 2 2 0 Phosphotransferase enzyme family IMS PF00817.20 EGD92824.1 - 9.8e-36 123.0 0.0 1.5e-21 76.9 0.0 2.4 2 0 0 2 2 2 2 impB/mucB/samB family zf_UBZ PF18439.1 EGD92824.1 - 2.9e-12 45.9 1.0 6.1e-12 44.9 1.0 1.6 1 0 0 1 1 1 1 Ubiquitin-Binding Zinc Finger IMS_C PF11799.8 EGD92824.1 - 2e-11 44.6 0.0 3.9e-11 43.7 0.0 1.4 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain Ribophorin_II PF05817.14 EGD92827.1 - 0.68 8.4 1.4 0.89 8.0 1.4 1.1 1 0 0 1 1 1 0 Oligosaccharyltransferase subunit Ribophorin II CDC45 PF02724.14 EGD92827.1 - 8.2 4.6 8.7 11 4.1 8.7 1.1 1 0 0 1 1 1 0 CDC45-like protein WSC PF01822.19 EGD92828.1 - 1.3e-07 31.7 9.1 1.3e-07 31.7 9.1 1.8 2 0 0 2 2 2 1 WSC domain TMEM154 PF15102.6 EGD92828.1 - 0.00051 20.0 3.5 0.0023 17.8 3.5 1.9 1 1 0 1 1 1 1 TMEM154 protein family FixQ PF05545.11 EGD92828.1 - 0.017 15.1 0.1 0.038 14.0 0.1 1.6 1 0 0 1 1 1 0 Cbb3-type cytochrome oxidase component FixQ Mucin PF01456.17 EGD92828.1 - 0.038 14.0 16.5 0.08 12.9 16.5 1.5 1 0 0 1 1 1 0 Mucin-like glycoprotein DUF2207 PF09972.9 EGD92828.1 - 0.2 10.4 0.0 0.29 9.8 0.0 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) AJAP1_PANP_C PF15298.6 EGD92828.1 - 0.71 10.1 8.6 1.5 9.0 8.6 1.5 1 1 0 1 1 1 0 AJAP1/PANP C-terminus Transp_cyt_pur PF02133.15 EGD92829.1 - 7.9e-26 90.8 32.4 7.9e-26 90.8 32.4 1.5 1 1 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin PRP38 PF03371.15 EGD92831.1 - 9.1e-65 217.8 0.0 1.2e-64 217.4 0.0 1.0 1 0 0 1 1 1 1 PRP38 family Tnp_22_trimer PF17489.2 EGD92831.1 - 0.18 11.8 2.4 0.37 10.8 2.4 1.4 1 0 0 1 1 1 0 L1 transposable element trimerization domain FeoB_N PF02421.18 EGD92832.1 - 0.15 11.6 0.2 0.3 10.6 0.1 1.5 2 0 0 2 2 2 0 Ferrous iron transport protein B WD40 PF00400.32 EGD92833.1 - 2.7e-16 59.7 4.5 0.24 12.3 0.0 7.3 8 0 0 8 8 8 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EGD92833.1 - 0.0052 17.0 0.0 7.3 7.0 0.0 3.9 2 2 2 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain Trypan_PARP PF05887.11 EGD92833.1 - 0.013 15.5 5.3 0.013 15.5 5.3 2.3 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) PALB2_WD40 PF16756.5 EGD92833.1 - 0.12 11.3 0.0 0.19 10.7 0.0 1.3 1 0 0 1 1 1 0 Partner and localizer of BRCA2 WD40 domain AAA_12 PF13087.6 EGD92834.1 - 6.9e-38 130.3 0.0 1.1e-37 129.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 EGD92834.1 - 7.1e-25 88.3 0.0 2.4e-24 86.5 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EGD92834.1 - 9.5e-10 38.5 0.0 3.6e-07 30.1 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.6 EGD92834.1 - 2.1e-09 37.9 0.0 3.1e-08 34.1 0.0 2.4 1 1 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 EGD92834.1 - 5.7e-07 29.5 0.1 0.00042 20.1 0.0 3.4 3 1 0 3 3 3 1 Viral (Superfamily 1) RNA helicase ResIII PF04851.15 EGD92834.1 - 0.00027 21.0 0.0 0.00065 19.7 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EGD92834.1 - 0.00076 19.3 0.0 0.002 17.9 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase PhoH PF02562.16 EGD92834.1 - 0.0018 17.8 0.0 0.0035 16.8 0.0 1.4 1 0 0 1 1 1 1 PhoH-like protein DUF2075 PF09848.9 EGD92834.1 - 0.0084 15.4 0.1 0.38 9.9 0.0 2.5 3 0 0 3 3 3 1 Uncharacterized conserved protein (DUF2075) ABC_tran PF00005.27 EGD92835.1 - 2e-56 190.3 0.2 6.7e-31 107.6 0.0 2.6 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 EGD92835.1 - 1.8e-51 175.4 30.4 3.4e-34 118.7 13.5 3.5 3 0 0 3 3 3 2 ABC transporter transmembrane region SMC_N PF02463.19 EGD92835.1 - 3.2e-07 30.0 8.5 0.021 14.3 0.2 4.6 3 2 0 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EGD92835.1 - 2.9e-06 27.3 2.1 0.053 13.3 0.0 3.6 2 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system MMR_HSR1 PF01926.23 EGD92835.1 - 1e-05 25.6 0.2 0.035 14.2 0.0 2.9 2 0 0 2 2 2 2 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EGD92835.1 - 1.2e-05 25.3 0.3 0.15 11.9 0.1 2.5 2 0 0 2 2 2 2 RsgA GTPase AAA_23 PF13476.6 EGD92835.1 - 3.5e-05 24.4 8.1 0.00063 20.3 0.1 2.9 3 0 0 3 3 2 2 AAA domain AAA_29 PF13555.6 EGD92835.1 - 0.00018 21.2 1.1 0.51 10.1 0.1 3.3 3 0 0 3 3 3 2 P-loop containing region of AAA domain DUF87 PF01935.17 EGD92835.1 - 0.00056 20.1 1.2 0.018 15.2 0.0 2.5 2 0 0 2 2 2 1 Helicase HerA, central domain AAA_22 PF13401.6 EGD92835.1 - 0.0017 18.6 0.5 8.3 6.7 0.0 3.4 3 0 0 3 3 3 0 AAA domain AAA_25 PF13481.6 EGD92835.1 - 0.002 17.7 0.0 0.19 11.3 0.0 2.5 2 0 0 2 2 2 1 AAA domain T2SSE PF00437.20 EGD92835.1 - 0.0025 16.9 0.2 0.028 13.5 0.1 2.2 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA PF00004.29 EGD92835.1 - 0.014 15.8 0.3 3.2 8.2 0.0 3.3 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EGD92835.1 - 0.016 15.6 2.6 3.9 7.8 0.0 3.2 3 1 0 3 3 2 0 AAA ATPase domain Zeta_toxin PF06414.12 EGD92835.1 - 0.017 14.4 0.4 1.9 7.7 0.1 2.4 2 0 0 2 2 2 0 Zeta toxin IstB_IS21 PF01695.17 EGD92835.1 - 0.032 14.0 2.1 3 7.5 0.0 3.2 4 0 0 4 4 3 0 IstB-like ATP binding protein AAA_7 PF12775.7 EGD92835.1 - 0.042 13.4 0.2 10 5.6 0.0 2.5 2 0 0 2 2 2 0 P-loop containing dynein motor region FtsK_SpoIIIE PF01580.18 EGD92835.1 - 0.047 13.0 0.5 0.47 9.8 0.1 2.2 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_18 PF13238.6 EGD92835.1 - 0.071 13.7 0.0 14 6.2 0.0 3.0 2 0 0 2 2 2 0 AAA domain ResIII PF04851.15 EGD92835.1 - 0.075 13.0 0.0 12 5.9 0.0 2.9 3 0 0 3 3 3 0 Type III restriction enzyme, res subunit DEAD PF00270.29 EGD92835.1 - 0.12 12.1 0.1 3.2 7.5 0.0 2.8 3 0 0 3 3 3 0 DEAD/DEAH box helicase Adeno_IVa2 PF02456.15 EGD92835.1 - 0.22 10.3 0.5 0.77 8.5 0.1 1.9 2 0 0 2 2 2 0 Adenovirus IVa2 protein AAA_15 PF13175.6 EGD92835.1 - 0.27 10.9 3.6 0.81 9.3 0.0 2.8 4 0 0 4 4 2 0 AAA ATPase domain TrwB_AAD_bind PF10412.9 EGD92835.1 - 0.32 9.9 2.0 3.7 6.4 0.1 2.2 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain cobW PF02492.19 EGD92835.1 - 0.33 10.5 2.5 0.93 9.1 0.4 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain NACHT PF05729.12 EGD92835.1 - 0.49 10.3 2.8 5.4 6.9 0.3 2.5 2 0 0 2 2 2 0 NACHT domain Dynamin_N PF00350.23 EGD92835.1 - 4.9 7.2 6.7 10 6.2 0.4 3.0 3 0 0 3 3 3 0 Dynamin family Peptidase_M36 PF02128.15 EGD92836.1 - 3.5e-156 520.0 0.4 4.4e-156 519.7 0.4 1.1 1 0 0 1 1 1 1 Fungalysin metallopeptidase (M36) FTP PF07504.13 EGD92836.1 - 2.1e-16 59.5 3.1 2.1e-16 59.5 3.1 2.2 2 0 0 2 2 2 1 Fungalysin/Thermolysin Propeptide Motif Peptidase_M4_C PF02868.15 EGD92836.1 - 0.00051 19.9 0.0 0.0013 18.6 0.0 1.7 1 0 0 1 1 1 1 Thermolysin metallopeptidase, alpha-helical domain Colicin_M PF14859.6 EGD92836.1 - 0.025 13.7 0.0 0.044 12.9 0.0 1.3 1 0 0 1 1 1 0 Colicin M UQ_con PF00179.26 EGD92837.1 - 2.7e-38 130.8 0.0 3.3e-38 130.5 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 EGD92837.1 - 0.025 14.8 0.3 0.049 13.9 0.3 1.6 1 1 0 1 1 1 0 RWD domain Prok-E2_B PF14461.6 EGD92837.1 - 0.031 14.0 0.0 0.1 12.3 0.0 1.7 1 1 0 1 1 1 0 Prokaryotic E2 family B Bax1-I PF01027.20 EGD92838.1 - 1.8e-55 188.0 28.3 2.1e-55 187.8 28.3 1.0 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 SLATT_4 PF18186.1 EGD92838.1 - 2.2 7.9 3.9 1.1 8.9 0.8 1.9 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain family 4 Aa_trans PF01490.18 EGD92839.1 - 7.4e-88 295.0 17.2 1.1e-87 294.4 17.2 1.2 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein YfhO PF09586.10 EGD92839.1 - 0.096 10.9 3.4 0.16 10.2 3.4 1.3 1 0 0 1 1 1 0 Bacterial membrane protein YfhO Glyco_hydro_75 PF07335.11 EGD92840.1 - 1.4e-61 207.6 0.2 1.7e-61 207.3 0.2 1.1 1 0 0 1 1 1 1 Fungal chitosanase of glycosyl hydrolase group 75 EMC1_C PF07774.13 EGD92841.1 - 1.7e-77 259.9 0.0 2.9e-77 259.1 0.0 1.4 1 0 0 1 1 1 1 ER membrane protein complex subunit 1, C-terminal PQQ_2 PF13360.6 EGD92841.1 - 2e-21 76.7 10.8 5e-18 65.5 3.1 2.8 2 1 0 2 2 2 2 PQQ-like domain PQQ PF01011.21 EGD92841.1 - 2e-06 27.4 4.7 1.2 9.2 0.0 5.6 5 0 0 5 5 5 3 PQQ enzyme repeat AT_hook PF02178.19 EGD92842.1 - 4.9e-07 28.9 66.1 0.054 13.4 1.7 6.7 6 0 0 6 6 6 6 AT hook motif CRAL_TRIO PF00650.20 EGD92843.1 - 7.9e-24 84.2 0.0 1.1e-23 83.7 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 EGD92843.1 - 3.9e-08 33.4 0.0 1.4e-07 31.5 0.0 2.0 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain SNase PF00565.17 EGD92844.1 - 2e-80 266.3 0.1 6.7e-26 90.9 0.0 5.4 5 0 0 5 5 5 5 Staphylococcal nuclease homologue TUDOR PF00567.24 EGD92844.1 - 1.2e-24 86.7 0.0 3.4e-24 85.2 0.0 1.7 1 0 0 1 1 1 1 Tudor domain SMN PF06003.12 EGD92844.1 - 0.00024 20.5 0.0 0.00043 19.6 0.0 1.3 1 0 0 1 1 1 1 Survival motor neuron protein (SMN) Agenet PF05641.12 EGD92844.1 - 0.0094 16.4 0.9 0.046 14.2 0.2 2.6 3 0 0 3 3 3 1 Agenet domain DUF3297 PF11730.8 EGD92844.1 - 0.032 14.1 0.0 0.14 12.0 0.0 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3297) Fungal_trans PF04082.18 EGD92845.1 - 7.4e-26 90.8 0.2 1.5e-25 89.8 0.2 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EGD92845.1 - 2.1e-05 24.5 8.2 2.1e-05 24.5 8.2 1.8 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF4175 PF13779.6 EGD92845.1 - 0.2 9.5 1.6 0.32 8.9 1.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Sod_Cu PF00080.20 EGD92847.1 - 2.5e-46 157.4 5.4 2.9e-46 157.2 5.4 1.0 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) TAL_FSA PF00923.19 EGD92848.1 - 6.5e-95 317.8 0.1 7.4e-95 317.6 0.1 1.0 1 0 0 1 1 1 1 Transaldolase/Fructose-6-phosphate aldolase Beach PF02138.18 EGD92849.1 - 1.7e-118 395.0 0.0 2.8e-118 394.3 0.0 1.4 1 0 0 1 1 1 1 Beige/BEACH domain PH_BEACH PF14844.6 EGD92849.1 - 8.5e-10 38.6 0.1 8.5e-10 38.6 0.1 2.1 2 0 0 2 2 2 1 PH domain associated with Beige/BEACH WD40 PF00400.32 EGD92849.1 - 7.5e-08 32.9 4.2 0.0099 16.7 0.0 4.7 5 0 0 5 5 5 2 WD domain, G-beta repeat Laminin_G_3 PF13385.6 EGD92849.1 - 7.7e-07 29.4 0.0 2.4e-06 27.8 0.0 1.8 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Peptidase_S8 PF00082.22 EGD92850.1 - 2e-38 132.3 4.0 2.9e-38 131.8 4.0 1.3 1 0 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 EGD92850.1 - 3.7e-21 75.6 0.3 9.2e-21 74.3 0.3 1.7 1 0 0 1 1 1 1 Peptidase inhibitor I9 BIRC6 PF12356.8 EGD92851.1 - 0.0042 16.5 0.4 0.0059 16.1 0.4 1.2 1 0 0 1 1 1 1 Baculoviral IAP repeat-containing protein 6 Paf1 PF03985.13 EGD92851.1 - 0.2 10.6 4.3 0.24 10.4 4.3 1.1 1 0 0 1 1 1 0 Paf1 Nop14 PF04147.12 EGD92851.1 - 0.54 8.4 6.3 0.55 8.4 6.3 1.0 1 0 0 1 1 1 0 Nop14-like family Pox_Ag35 PF03286.14 EGD92851.1 - 1.5 8.6 5.2 2.2 8.0 5.2 1.2 1 0 0 1 1 1 0 Pox virus Ag35 surface protein GCP5-Mod21 PF14609.6 EGD92851.1 - 6.8 4.9 5.5 8.7 4.5 5.5 1.0 1 0 0 1 1 1 0 gamma-Tubulin ring complex non-core subunit mod21 FKBP_C PF00254.28 EGD92856.1 - 2.6e-10 40.5 0.0 1.1e-09 38.5 0.0 1.8 1 1 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase MINDY_DUB PF04424.13 EGD92858.1 - 2.7e-19 69.3 0.0 4.3e-19 68.7 0.0 1.3 1 0 0 1 1 1 1 MINDY deubiquitinase Gcd10p PF04189.13 EGD92859.1 - 7.9e-113 376.5 0.0 1.5e-110 369.0 0.0 2.2 1 1 0 1 1 1 1 Gcd10p family Heme_oxygenase PF01126.20 EGD92862.1 - 0.1 12.3 0.0 0.18 11.6 0.0 1.4 1 0 0 1 1 1 0 Heme oxygenase CorA PF01544.18 EGD92863.1 - 0.00032 20.1 1.2 0.00058 19.3 0.6 1.7 1 1 0 1 1 1 1 CorA-like Mg2+ transporter protein CNF1 PF05785.12 EGD92863.1 - 0.02 14.2 0.0 0.03 13.6 0.0 1.3 1 0 0 1 1 1 0 Rho-activating domain of cytotoxic necrotizing factor NmrA PF05368.13 EGD92864.1 - 6.4e-55 186.2 0.1 8.3e-55 185.9 0.1 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EGD92864.1 - 1.6e-17 64.0 0.0 2.2e-17 63.5 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding 3Beta_HSD PF01073.19 EGD92864.1 - 1.5e-05 24.1 0.0 2.2e-05 23.6 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family AIG1 PF04548.16 EGD92864.1 - 0.052 12.9 0.1 0.082 12.2 0.1 1.3 1 0 0 1 1 1 0 AIG1 family Epimerase PF01370.21 EGD92864.1 - 0.081 12.4 0.0 0.13 11.7 0.0 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Sacchrp_dh_NADP PF03435.18 EGD92864.1 - 0.11 12.7 0.1 0.19 12.0 0.1 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Myb_DNA-binding PF00249.31 EGD92866.1 - 8.9e-17 61.0 0.0 8.5e-09 35.5 0.0 2.5 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EGD92866.1 - 4.7e-06 26.8 0.0 0.044 14.0 0.1 2.9 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 EGD92866.1 - 4.6e-05 23.2 4.4 0.00029 20.7 0.0 3.5 3 0 0 3 3 3 1 Myb DNA-binding like DS PF01916.17 EGD92868.1 - 1.7e-129 431.2 0.0 2e-129 431.0 0.0 1.0 1 0 0 1 1 1 1 Deoxyhypusine synthase Pkinase PF00069.25 EGD92869.1 - 0.0013 18.2 0.0 0.0016 17.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain UCH PF00443.29 EGD92870.1 - 1.3e-10 41.2 0.0 2.6e-10 40.2 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-C3HC4_3 PF13920.6 EGD92870.1 - 3.2e-10 39.7 11.8 5.3e-10 39.0 11.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) MORN PF02493.20 EGD92870.1 - 3.4e-06 26.6 23.6 0.025 14.5 4.8 4.6 4 0 0 4 4 4 3 MORN repeat Prok-RING_4 PF14447.6 EGD92870.1 - 0.0097 15.8 10.6 0.019 14.8 10.6 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 USP7_ICP0_bdg PF12436.8 EGD92870.1 - 0.11 11.8 0.0 0.98 8.7 0.0 2.1 2 0 0 2 2 2 0 ICP0-binding domain of Ubiquitin-specific protease 7 zf-RING_5 PF14634.6 EGD92870.1 - 0.61 10.1 12.4 1.2 9.2 12.4 1.5 1 0 0 1 1 1 0 zinc-RING finger domain Abhydrolase_1 PF00561.20 EGD92872.1 - 3.3e-11 43.3 2.9 2.7e-10 40.3 2.9 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EGD92872.1 - 5.6e-09 36.9 1.0 7.2e-09 36.6 1.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EGD92872.1 - 0.00085 18.7 0.0 0.0013 18.0 0.0 1.4 1 1 0 1 1 1 1 Serine aminopeptidase, S33 HsbA PF12296.8 EGD92874.1 - 5.7e-29 101.0 7.8 5.7e-29 101.0 6.4 1.7 1 1 0 1 1 1 1 Hydrophobic surface binding protein A MF_alpha_N PF05436.11 EGD92874.1 - 0.046 13.6 1.7 0.083 12.8 0.5 2.1 2 0 0 2 2 2 0 Mating factor alpha precursor N-terminus DUF3216 PF11505.8 EGD92874.1 - 0.096 12.9 0.1 0.6 10.3 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3216) PIG-P PF08510.12 EGD92875.1 - 8.5e-49 164.5 0.6 8.5e-49 164.5 0.6 1.7 2 0 0 2 2 2 1 PIG-P DPM2 PF07297.12 EGD92875.1 - 0.011 16.0 7.8 0.02 15.2 7.8 1.3 1 0 0 1 1 1 0 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) CDC45 PF02724.14 EGD92875.1 - 0.036 12.4 0.0 0.05 11.9 0.0 1.1 1 0 0 1 1 1 0 CDC45-like protein BUD22 PF09073.10 EGD92875.1 - 0.044 13.1 6.5 0.055 12.8 6.5 1.2 1 0 0 1 1 1 0 BUD22 SDA1 PF05285.12 EGD92875.1 - 0.064 12.7 3.7 0.079 12.4 3.7 1.1 1 0 0 1 1 1 0 SDA1 Phage_holin_3_6 PF07332.11 EGD92875.1 - 0.27 11.3 0.1 0.42 10.7 0.1 1.2 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III Rab5ip PF07019.12 EGD92875.1 - 0.33 11.6 2.6 0.69 10.5 2.6 1.5 1 0 0 1 1 1 0 Rab5-interacting protein (Rab5ip) XPA_C PF05181.12 EGD92876.1 - 2.8e-26 91.2 2.3 5.6e-26 90.3 2.3 1.6 1 0 0 1 1 1 1 XPA protein C-terminus YhfH PF14149.6 EGD92876.1 - 0.0066 16.4 3.3 0.89 9.6 0.2 2.8 2 0 0 2 2 2 2 YhfH-like protein ADD_DNMT3 PF17980.1 EGD92876.1 - 0.28 11.2 3.3 0.12 12.4 0.5 1.7 2 0 0 2 2 2 0 Cysteine rich ADD domain in DNMT3 Ribosomal_L32e PF01655.18 EGD92876.1 - 0.34 11.3 2.2 0.46 10.9 0.5 2.0 2 0 0 2 2 2 0 Ribosomal protein L32 MAS20 PF02064.15 EGD92876.1 - 2.1 8.4 5.6 0.52 10.4 1.6 2.0 2 0 0 2 2 2 0 MAS20 protein import receptor Striatin PF08232.12 EGD92877.1 - 8e-47 159.7 3.6 8e-47 159.7 3.6 2.6 2 1 0 2 2 2 1 Striatin family WD40 PF00400.32 EGD92877.1 - 1.5e-25 89.0 22.3 2.4e-05 25.0 0.4 8.0 8 1 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EGD92877.1 - 0.00013 22.2 0.0 5.2 7.4 0.0 4.4 3 1 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EGD92877.1 - 0.13 12.2 0.0 0.21 11.4 0.0 1.3 1 0 0 1 1 1 0 Eukaryotic translation initiation factor eIF2A Cytochrom_D1 PF02239.16 EGD92877.1 - 0.14 10.7 0.0 0.31 9.5 0.0 1.5 1 0 0 1 1 1 0 Cytochrome D1 heme domain Blt1 PF12754.7 EGD92878.1 - 3.4e-58 196.2 0.3 4.5e-58 195.8 0.3 1.2 1 0 0 1 1 1 1 Blt1 N-terminal domain Blt1_C PF17183.4 EGD92878.1 - 0.0066 16.0 0.0 0.018 14.7 0.0 1.7 1 0 0 1 1 1 1 Get5 carboxyl domain DUF2340 PF10209.9 EGD92878.1 - 0.016 15.7 0.0 0.025 15.0 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2340) Pyridox_ox_2 PF12900.7 EGD92878.1 - 0.14 12.1 0.0 0.27 11.2 0.0 1.5 1 1 0 1 1 1 0 Pyridoxamine 5'-phosphate oxidase Methyltr_RsmB-F PF01189.17 EGD92879.1 - 1.7e-73 246.6 0.0 2.6e-73 246.0 0.0 1.3 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Methyltr_RsmF_N PF17125.5 EGD92879.1 - 1.8e-07 31.5 0.0 1.4e-06 28.7 0.0 2.3 2 0 0 2 2 2 1 N-terminal domain of 16S rRNA methyltransferase RsmF FtsJ PF01728.19 EGD92879.1 - 0.016 15.4 0.0 0.031 14.4 0.0 1.4 1 0 0 1 1 1 0 FtsJ-like methyltransferase DUF4717 PF15838.5 EGD92879.1 - 0.17 11.9 3.0 0.5 10.4 3.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4717) EamA PF00892.20 EGD92880.1 - 1.9e-05 24.8 6.7 1.9e-05 24.8 6.7 2.2 2 0 0 2 2 2 2 EamA-like transporter family Dscam_C PF12355.8 EGD92880.1 - 0.66 10.9 4.5 0.16 12.9 1.2 1.6 2 0 0 2 2 2 0 Down syndrome cell adhesion molecule C terminal DUF2431 PF10354.9 EGD92881.1 - 5.6e-45 153.6 0.0 9.2e-45 152.9 0.0 1.3 1 1 0 1 1 1 1 Domain of unknown function (DUF2431) RAB3GAP2_N PF14655.6 EGD92881.1 - 0.96 8.6 2.7 1.5 8.0 2.7 1.2 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus CLTH PF10607.9 EGD92882.1 - 1.1e-35 122.7 0.5 1.9e-35 121.9 0.1 1.6 2 0 0 2 2 2 1 CTLH/CRA C-terminal to LisH motif domain INCA1 PF15142.6 EGD92882.1 - 0.061 13.3 0.4 0.13 12.3 0.2 1.6 2 0 0 2 2 2 0 INCA1 DUF5398 PF17376.2 EGD92882.1 - 0.062 13.9 0.6 4.8 7.9 0.0 2.6 1 1 1 2 2 2 0 Family of unknown function (DUF5398) SKA2 PF16740.5 EGD92882.1 - 0.47 10.3 3.7 0.26 11.1 0.5 2.2 3 0 0 3 3 3 0 Spindle and kinetochore-associated protein 2 Adaptin_binding PF10199.9 EGD92882.1 - 0.54 10.9 2.4 0.35 11.5 0.3 1.8 2 0 0 2 2 2 0 Alpha and gamma adaptin binding protein p34 GIT_CC PF16559.5 EGD92882.1 - 3.8 7.4 5.4 10 6.1 0.9 2.6 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor DKCLD PF08068.12 EGD92883.1 - 9.3e-34 115.3 0.2 2.6e-32 110.7 0.3 2.6 2 0 0 2 2 2 1 DKCLD (NUC011) domain TruB_C_2 PF16198.5 EGD92883.1 - 3.9e-23 81.4 1.5 7.1e-23 80.5 1.5 1.5 1 0 0 1 1 1 1 tRNA pseudouridylate synthase B C-terminal domain TruB_N PF01509.18 EGD92883.1 - 5.5e-23 82.0 0.2 6e-20 72.1 0.2 3.5 1 1 0 1 1 1 1 TruB family pseudouridylate synthase (N terminal domain) PUA PF01472.20 EGD92883.1 - 7.6e-21 73.9 1.3 1.5e-20 72.9 1.3 1.5 1 0 0 1 1 1 1 PUA domain UPF0113 PF03657.13 EGD92883.1 - 0.0049 17.1 0.0 0.012 15.8 0.0 1.7 1 0 0 1 1 1 1 UPF0113 PUA domain DUF4407 PF14362.6 EGD92883.1 - 1.1 8.6 11.8 1.9 7.7 11.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DER1 PF04511.15 EGD92884.1 - 2.8e-25 89.4 3.1 3.2e-25 89.2 3.1 1.0 1 0 0 1 1 1 1 Der1-like family Rhomboid PF01694.22 EGD92884.1 - 0.32 11.0 10.0 0.029 14.4 4.7 1.8 2 0 0 2 2 2 0 Rhomboid family Abhydrolase_3 PF07859.13 EGD92885.1 - 1.5e-44 152.3 0.0 8e-43 146.8 0.0 2.3 1 1 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 EGD92885.1 - 1.8e-07 30.4 0.3 1.4e-06 27.5 0.3 1.8 1 1 0 1 1 1 1 Carboxylesterase family Esterase_phd PF10503.9 EGD92885.1 - 0.13 11.7 0.1 2.5 7.5 0.1 2.1 2 0 0 2 2 2 0 Esterase PHB depolymerase MaoC_dehydratas PF01575.19 EGD92886.1 - 0.0018 17.8 0.0 0.0031 17.1 0.0 1.3 1 0 0 1 1 1 1 MaoC like domain PDT PF00800.18 EGD92887.1 - 2.7e-58 196.8 0.0 3.6e-58 196.4 0.0 1.2 1 0 0 1 1 1 1 Prephenate dehydratase ACT PF01842.25 EGD92887.1 - 6.6e-06 25.8 0.0 2.5e-05 23.9 0.0 2.0 1 1 0 1 1 1 1 ACT domain eRF1_2 PF03464.15 EGD92888.1 - 1.6e-46 158.0 0.0 2.5e-46 157.3 0.0 1.3 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.15 EGD92888.1 - 4.5e-39 133.4 0.2 1.1e-38 132.1 0.2 1.7 1 0 0 1 1 1 1 eRF1 domain 3 eRF1_1 PF03463.15 EGD92888.1 - 2.1e-19 69.8 0.0 3.3e-19 69.2 0.0 1.3 1 0 0 1 1 1 1 eRF1 domain 1 baeRF_family10 PF18854.1 EGD92888.1 - 5.1e-10 39.8 0.0 9.3e-10 38.9 0.0 1.4 1 0 0 1 1 1 1 Bacterial archaeo-eukaryotic release factor family 10 acVLRF1 PF18859.1 EGD92888.1 - 1.1e-08 35.4 0.0 1.8e-08 34.7 0.0 1.3 1 0 0 1 1 1 1 Actinobacteria/chloroflexi VLRF1 release factor Bmt2 PF11968.8 EGD92890.1 - 1.5e-86 289.8 0.0 1.8e-86 289.6 0.0 1.1 1 0 0 1 1 1 1 25S rRNA (adenine(2142)-N(1))-methyltransferase, Bmt2 Methyltransf_23 PF13489.6 EGD92890.1 - 0.033 14.0 0.0 0.043 13.6 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Ribosomal_L23eN PF03939.13 EGD92891.1 - 5e-27 93.9 8.8 5e-27 93.9 8.8 1.7 1 1 0 1 1 1 1 Ribosomal protein L23, N-terminal domain Ribosomal_L23 PF00276.20 EGD92891.1 - 4.3e-13 49.4 3.9 5.4e-13 49.1 0.3 2.2 2 1 0 2 2 2 1 Ribosomal protein L23 Linker_histone PF00538.19 EGD92891.1 - 0.43 11.0 3.2 0.34 11.3 0.3 2.1 2 0 0 2 2 2 0 linker histone H1 and H5 family Forkhead PF00250.18 EGD92892.1 - 8.9e-34 115.6 0.0 1.6e-33 114.8 0.0 1.4 1 0 0 1 1 1 1 Forkhead domain G10 PF01125.17 EGD92893.1 - 1.1e-67 226.3 4.6 1.3e-67 226.2 4.6 1.0 1 0 0 1 1 1 1 G10 protein zf-Tim10_DDP PF02953.15 EGD92894.1 - 2.1e-18 65.7 2.0 2.7e-18 65.3 2.0 1.2 1 0 0 1 1 1 1 Tim10/DDP family zinc finger AA_kinase PF00696.28 EGD92895.1 - 3.5e-42 144.7 0.1 5.5e-42 144.0 0.1 1.3 1 0 0 1 1 1 1 Amino acid kinase family ACT_7 PF13840.6 EGD92895.1 - 2.7e-14 52.7 1.5 1.5e-11 43.9 0.2 2.6 2 0 0 2 2 2 2 ACT domain ACT PF01842.25 EGD92895.1 - 1.1e-12 47.5 0.1 5.2e-09 35.7 0.1 2.9 3 0 0 3 3 3 2 ACT domain Peptidase_C78 PF07910.13 EGD92897.1 - 8.6e-66 221.4 0.0 1.1e-65 221.0 0.0 1.1 1 0 0 1 1 1 1 Peptidase family C78 zf-Di19 PF05605.12 EGD92897.1 - 0.00082 19.6 3.2 0.071 13.4 1.0 2.5 2 0 0 2 2 2 2 Drought induced 19 protein (Di19), zinc-binding zf_UBZ PF18439.1 EGD92897.1 - 0.0035 16.9 0.0 0.0077 15.8 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin-Binding Zinc Finger zf-H2C2_5 PF13909.6 EGD92897.1 - 0.19 11.5 0.5 0.42 10.4 0.5 1.6 1 0 0 1 1 1 0 C2H2-type zinc-finger domain zf-C2H2_4 PF13894.6 EGD92897.1 - 1.1 10.3 3.7 6 8.0 1.3 2.7 2 0 0 2 2 2 0 C2H2-type zinc finger AAA_18 PF13238.6 EGD92898.1 - 2.8e-26 92.6 0.1 5.2e-26 91.7 0.0 1.5 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.6 EGD92898.1 - 4.1e-08 33.7 0.0 1.1e-07 32.3 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA PF00004.29 EGD92898.1 - 0.00035 21.0 0.0 0.00067 20.1 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EGD92898.1 - 0.0018 18.7 0.2 0.014 15.7 0.2 2.0 1 1 0 1 1 1 1 AAA ATPase domain AAA_28 PF13521.6 EGD92898.1 - 0.0019 18.5 0.6 0.0032 17.7 0.6 1.8 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EGD92898.1 - 0.0019 18.3 0.1 0.033 14.4 0.0 2.1 1 1 0 2 2 2 1 AAA domain AAA_22 PF13401.6 EGD92898.1 - 0.0024 18.1 0.0 0.0051 17.1 0.0 1.6 2 0 0 2 2 2 1 AAA domain AAA_14 PF13173.6 EGD92898.1 - 0.0029 17.6 0.0 0.0075 16.3 0.0 1.7 2 0 0 2 2 2 1 AAA domain ADK PF00406.22 EGD92898.1 - 0.0043 17.2 0.1 0.018 15.2 0.0 1.9 1 1 1 2 2 2 1 Adenylate kinase NTPase_1 PF03266.15 EGD92898.1 - 0.0055 16.6 0.1 0.015 15.2 0.0 1.7 2 0 0 2 2 2 1 NTPase KTI12 PF08433.10 EGD92898.1 - 0.0067 15.9 0.0 0.017 14.6 0.0 1.6 2 0 0 2 2 2 1 Chromatin associated protein KTI12 Hydin_ADK PF17213.3 EGD92898.1 - 0.016 15.5 0.0 0.029 14.7 0.0 1.4 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain RNA_helicase PF00910.22 EGD92898.1 - 0.038 14.4 0.0 0.063 13.7 0.0 1.4 1 0 0 1 1 1 0 RNA helicase IstB_IS21 PF01695.17 EGD92898.1 - 0.13 11.9 0.0 0.22 11.3 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_3 PF07726.11 EGD92898.1 - 0.14 12.0 0.0 0.23 11.3 0.0 1.3 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 EGD92898.1 - 0.18 11.3 0.0 0.25 10.8 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_19 PF13245.6 EGD92898.1 - 0.21 11.9 0.3 0.4 11.0 0.2 1.5 1 1 0 1 1 1 0 AAA domain Ham1p_like PF01725.16 EGD92899.1 - 6.8e-57 192.4 0.0 7.7e-57 192.2 0.0 1.0 1 0 0 1 1 1 1 Ham1 family Myosin_head PF00063.21 EGD92900.1 - 2e-263 875.7 2.6 2.8e-263 875.2 2.6 1.2 1 0 0 1 1 1 1 Myosin head (motor domain) DIL PF01843.19 EGD92900.1 - 3.2e-26 91.6 2.6 3.2e-26 91.6 2.6 3.2 3 1 1 4 4 3 1 DIL domain IQ PF00612.27 EGD92900.1 - 8.4e-12 43.8 31.9 3.7e-05 23.1 0.6 6.8 6 0 0 6 6 6 3 IQ calmodulin-binding motif GAS PF13851.6 EGD92900.1 - 0.00093 18.6 15.0 0.00093 18.6 15.0 2.8 1 1 1 2 2 2 1 Growth-arrest specific micro-tubule binding AAA_16 PF13191.6 EGD92900.1 - 0.0031 17.9 0.0 0.013 15.9 0.0 2.1 1 0 0 1 1 1 1 AAA ATPase domain Myosin_N PF02736.19 EGD92900.1 - 0.0032 17.3 3.3 0.0082 16.0 3.3 1.7 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain Spc7 PF08317.11 EGD92900.1 - 0.0033 16.3 20.5 0.0041 16.0 19.0 1.9 1 1 0 1 1 1 1 Spc7 kinetochore protein AAA_22 PF13401.6 EGD92900.1 - 0.0097 16.2 0.1 0.0097 16.2 0.1 2.8 2 1 0 2 2 2 1 AAA domain T2SSE PF00437.20 EGD92900.1 - 0.017 14.2 0.0 0.039 13.0 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein CALCOCO1 PF07888.11 EGD92900.1 - 0.048 12.5 19.6 0.11 11.4 19.6 1.5 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like EzrA PF06160.12 EGD92900.1 - 0.059 11.5 16.0 0.41 8.8 2.7 2.4 1 1 0 2 2 2 0 Septation ring formation regulator, EzrA RNA_helicase PF00910.22 EGD92900.1 - 0.088 13.2 0.0 0.36 11.2 0.0 2.1 2 0 0 2 2 1 0 RNA helicase TsaE PF02367.17 EGD92900.1 - 0.11 12.4 0.0 0.33 11.0 0.0 1.7 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Fez1 PF06818.15 EGD92900.1 - 0.32 11.4 19.3 1.7 9.1 19.4 2.2 1 1 0 1 1 1 0 Fez1 KASH_CCD PF14662.6 EGD92900.1 - 0.71 9.7 23.5 0.3 10.9 19.2 2.4 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 or KASH Baculo_PEP_C PF04513.12 EGD92900.1 - 0.74 9.9 10.3 0.27 11.2 4.9 3.0 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus FlaC_arch PF05377.11 EGD92900.1 - 1.8 9.0 10.9 1.3 9.5 0.1 4.0 3 1 1 4 4 4 0 Flagella accessory protein C (FlaC) TPR_MLP1_2 PF07926.12 EGD92900.1 - 4.5 7.3 26.8 0.076 13.1 3.3 3.3 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein NAP PF00956.18 EGD92901.1 - 1.9e-98 328.9 7.4 1.9e-98 328.9 7.4 1.7 2 0 0 2 2 2 1 Nucleosome assembly protein (NAP) DUF2457 PF10446.9 EGD92901.1 - 4.4 6.3 35.9 1.5 7.8 25.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2457) Nop14 PF04147.12 EGD92901.1 - 4.6 5.3 33.7 0.72 8.0 24.1 2.1 2 0 0 2 2 2 0 Nop14-like family P5-ATPase PF12409.8 EGD92902.1 - 1.7e-40 138.0 0.0 3.7e-40 136.9 0.0 1.6 1 0 0 1 1 1 1 P5-type ATPase cation transporter E1-E2_ATPase PF00122.20 EGD92902.1 - 3.1e-30 105.0 1.1 4.8e-30 104.4 0.0 1.8 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 EGD92902.1 - 1.2e-14 55.1 0.0 4.4e-08 33.7 0.0 3.1 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EGD92902.1 - 0.0005 19.7 0.0 0.0013 18.4 0.0 1.7 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Cation_ATPase PF13246.6 EGD92902.1 - 0.00056 19.9 0.0 0.0013 18.7 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 EGD92902.1 - 0.0051 16.6 0.0 2.9 7.5 0.0 2.4 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase G_glu_transpept PF01019.21 EGD92903.1 - 2e-124 416.2 0.0 2.6e-124 415.8 0.0 1.0 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase Peptidase_S64 PF08192.11 EGD92904.1 - 2.3e-08 33.0 0.7 4.6e-08 32.1 0.7 1.6 1 1 0 1 1 1 1 Peptidase family S64 Peptidase_S7 PF00949.21 EGD92904.1 - 2.4e-05 24.1 0.0 0.0012 18.7 0.0 2.7 2 0 0 2 2 2 1 Peptidase S7, Flavivirus NS3 serine protease Trypsin_2 PF13365.6 EGD92904.1 - 0.00014 22.8 0.0 0.00067 20.6 0.0 2.0 1 1 0 1 1 1 1 Trypsin-like peptidase domain Peptidase_S32 PF05579.13 EGD92904.1 - 0.0025 17.1 0.0 0.004 16.4 0.0 1.2 1 0 0 1 1 1 1 Equine arteritis virus serine endopeptidase S32 DUF31 PF01732.16 EGD92904.1 - 0.058 12.9 0.3 0.22 11.0 0.1 1.8 2 0 0 2 2 2 0 Putative peptidase (DUF31) ANAPC15 PF15243.6 EGD92904.1 - 0.078 13.4 0.0 0.16 12.4 0.0 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 15 Pkinase PF00069.25 EGD92905.1 - 2.6e-65 220.4 0.0 3.1e-65 220.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD92905.1 - 1e-30 106.9 0.0 1.4e-30 106.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EGD92905.1 - 0.0019 17.2 0.0 0.0027 16.7 0.0 1.1 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 EGD92905.1 - 0.0068 15.8 0.0 0.016 14.5 0.0 1.7 1 1 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EGD92905.1 - 0.035 12.9 0.0 0.052 12.3 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase FTA2 PF13095.6 EGD92905.1 - 0.095 12.3 0.0 4.8 6.7 0.0 2.1 1 1 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 UPF0242 PF06785.11 EGD92906.1 - 0.022 14.9 4.8 0.024 14.8 4.8 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DUF2681 PF10883.8 EGD92906.1 - 0.024 15.0 1.9 0.038 14.4 0.7 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2681) PMSI1 PF15322.6 EGD92906.1 - 0.027 13.9 1.5 0.032 13.7 1.5 1.1 1 0 0 1 1 1 0 Protein missing in infertile sperm 1, putative BBP1_C PF15272.6 EGD92906.1 - 0.028 14.3 5.0 0.034 14.0 5.0 1.2 1 0 0 1 1 1 0 Spindle pole body component BBP1, C-terminal DUF1489 PF07370.11 EGD92906.1 - 0.037 13.7 0.8 0.058 13.1 0.8 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1489) ATP-synt_E PF05680.12 EGD92906.1 - 0.4 11.1 6.7 0.13 12.7 0.8 2.1 2 0 0 2 2 2 0 ATP synthase E chain FUSC PF04632.12 EGD92906.1 - 4.4 5.7 6.1 5.6 5.4 6.1 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family Vpu PF00558.19 EGD92906.1 - 9.2 6.1 9.2 0.3 10.9 0.3 2.5 1 1 2 3 3 3 0 Vpu protein 2-Hacid_dh_C PF02826.19 EGD92907.1 - 9.1e-49 165.2 0.0 1.4e-48 164.6 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EGD92907.1 - 2.2e-34 118.0 0.0 3.1e-34 117.5 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain ACT PF01842.25 EGD92907.1 - 7.4e-05 22.4 0.2 0.00021 21.0 0.1 1.8 2 0 0 2 2 2 1 ACT domain NAD_binding_2 PF03446.15 EGD92907.1 - 0.00012 22.3 0.3 0.00033 20.9 0.3 1.7 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase AdoHcyase_NAD PF00670.21 EGD92907.1 - 0.0081 16.2 0.1 0.018 15.1 0.1 1.5 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain IlvN PF07991.12 EGD92907.1 - 0.014 15.0 0.1 0.038 13.6 0.0 1.7 2 0 0 2 2 2 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain XdhC_C PF13478.6 EGD92907.1 - 0.016 15.7 0.1 0.06 13.9 0.0 1.9 2 0 0 2 2 2 0 XdhC Rossmann domain DUF1780 PF08682.10 EGD92907.1 - 0.046 13.4 0.0 0.095 12.4 0.0 1.5 1 0 0 1 1 1 0 Putative endonuclease, protein of unknown function (DUF1780) 3HCDH_N PF02737.18 EGD92907.1 - 0.19 11.6 1.7 3.2 7.6 0.6 2.7 2 1 1 3 3 3 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain tRNA-synt_2b PF00587.25 EGD92908.1 - 3e-34 118.6 0.0 5.2e-34 117.8 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.22 EGD92908.1 - 7.8e-20 71.1 4.8 7.8e-20 71.1 4.8 1.9 3 0 0 3 3 3 1 Seryl-tRNA synthetase N-terminal domain CAMSAP_CC1 PF17095.5 EGD92908.1 - 0.034 14.0 2.7 0.076 12.9 2.7 1.5 1 0 0 1 1 1 0 Spectrin-binding region of Ca2+-Calmodulin DUF3698 PF12479.8 EGD92908.1 - 0.087 13.4 0.2 0.4 11.2 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3698) DUF4337 PF14235.6 EGD92908.1 - 2 8.5 4.8 4 7.5 4.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) Ras PF00071.22 EGD92909.1 - 4.3e-47 159.7 0.2 4.9e-47 159.5 0.2 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EGD92909.1 - 5.1e-17 62.2 0.1 7.5e-17 61.7 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EGD92909.1 - 3.5e-07 29.8 0.0 3.8e-07 29.7 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EGD92909.1 - 1.3e-05 24.8 0.2 0.00024 20.7 0.1 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EGD92909.1 - 0.00012 22.2 0.1 0.00018 21.6 0.1 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EGD92909.1 - 0.0011 18.9 0.0 0.33 10.8 0.0 2.1 2 0 0 2 2 2 2 RsgA GTPase SRPRB PF09439.10 EGD92909.1 - 0.0016 17.9 0.0 0.0023 17.4 0.0 1.4 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_7 PF12775.7 EGD92909.1 - 0.011 15.2 0.1 0.02 14.4 0.1 1.5 2 0 0 2 2 2 0 P-loop containing dynein motor region DUF3568 PF12092.8 EGD92909.1 - 0.06 13.4 0.1 0.11 12.6 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3568) AAA_14 PF13173.6 EGD92909.1 - 0.11 12.6 0.1 0.17 12.0 0.1 1.3 1 0 0 1 1 1 0 AAA domain NolV PF06635.12 EGD92910.1 - 0.12 11.8 2.6 6.8 6.0 1.4 2.1 2 0 0 2 2 2 0 Nodulation protein NolV TAF1D PF15333.6 EGD92911.1 - 0.15 11.8 0.6 0.25 11.1 0.6 1.3 1 0 0 1 1 1 0 TATA box-binding protein-associated factor 1D WAPL PF07814.13 EGD92913.1 - 9.4e-79 264.8 2.5 1.4e-78 264.2 2.5 1.3 1 0 0 1 1 1 1 Wings apart-like protein regulation of heterochromatin RIX1 PF08167.12 EGD92913.1 - 0.033 13.9 0.4 0.27 10.9 0.2 2.3 2 0 0 2 2 2 0 rRNA processing/ribosome biogenesis UPRTase PF14681.6 EGD92914.1 - 6.3e-77 257.7 0.0 8.3e-77 257.3 0.0 1.0 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Pribosyltran PF00156.27 EGD92914.1 - 0.012 15.1 0.0 0.016 14.7 0.0 1.2 1 0 0 1 1 1 0 Phosphoribosyl transferase domain Elf1 PF05129.13 EGD92915.1 - 9.1e-28 96.1 0.6 1.4e-27 95.6 0.6 1.3 1 0 0 1 1 1 1 Transcription elongation factor Elf1 like Peptidase_U32 PF01136.19 EGD92915.1 - 0.1 11.7 0.0 0.13 11.4 0.0 1.1 1 0 0 1 1 1 0 Peptidase family U32 GTP_CH_N PF12471.8 EGD92916.1 - 4.8e-91 303.8 0.0 6.7e-91 303.3 0.0 1.2 1 0 0 1 1 1 1 GTP cyclohydrolase N terminal GTP_cyclohydro2 PF00925.20 EGD92916.1 - 1.4e-17 63.7 0.0 2.3e-17 63.1 0.0 1.3 1 0 0 1 1 1 1 GTP cyclohydrolase II Ribosomal_S3Ae PF01015.18 EGD92917.1 - 1.4e-84 282.7 5.0 1.7e-84 282.4 5.0 1.1 1 0 0 1 1 1 1 Ribosomal S3Ae family SUI1 PF01253.22 EGD92917.1 - 0.017 15.7 0.4 0.096 13.2 0.2 2.2 1 1 1 2 2 2 0 Translation initiation factor SUI1 LPD1 PF18796.1 EGD92917.1 - 0.15 12.2 0.1 0.6 10.3 0.0 2.0 2 0 0 2 2 2 0 Large polyvalent protein-associated domain 1 Abhydrolase_1 PF00561.20 EGD92918.1 - 5.1e-23 82.0 0.0 2.1e-21 76.7 0.0 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EGD92918.1 - 5.2e-15 56.6 0.0 7.7e-15 56.1 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EGD92918.1 - 1.9e-11 43.7 0.0 4.4e-11 42.5 0.0 1.7 2 0 0 2 2 2 1 Serine aminopeptidase, S33 PGAP1 PF07819.13 EGD92918.1 - 9.5e-07 28.8 0.2 0.008 15.9 0.0 2.1 1 1 1 2 2 2 2 PGAP1-like protein Thioesterase PF00975.20 EGD92918.1 - 1.3e-05 25.4 0.0 2.4e-05 24.6 0.0 1.4 1 1 0 1 1 1 1 Thioesterase domain Esterase PF00756.20 EGD92918.1 - 0.0011 18.6 0.0 0.0027 17.4 0.0 1.4 1 1 0 1 1 1 1 Putative esterase Ndr PF03096.14 EGD92918.1 - 0.0023 16.7 0.0 0.0035 16.1 0.0 1.2 1 0 0 1 1 1 1 Ndr family Chlorophyllase PF07224.11 EGD92918.1 - 0.0054 15.8 0.0 0.0092 15.0 0.0 1.3 1 0 0 1 1 1 1 Chlorophyllase Chlorophyllase2 PF12740.7 EGD92918.1 - 0.0075 15.2 0.0 0.014 14.4 0.0 1.4 1 0 0 1 1 1 1 Chlorophyllase enzyme Abhydrolase_5 PF12695.7 EGD92918.1 - 0.012 15.4 0.0 0.034 13.9 0.0 1.7 2 0 0 2 2 2 0 Alpha/beta hydrolase family DUF915 PF06028.11 EGD92918.1 - 0.015 14.6 0.0 0.59 9.4 0.0 2.4 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF915) Abhydrolase_3 PF07859.13 EGD92918.1 - 0.021 14.7 0.0 0.032 14.1 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold Palm_thioest PF02089.15 EGD92918.1 - 0.029 14.2 0.0 0.037 13.8 0.0 1.3 1 0 0 1 1 1 0 Palmitoyl protein thioesterase DUF3089 PF11288.8 EGD92918.1 - 0.11 12.0 0.0 0.91 9.0 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3089) Abhydro_lipase PF04083.16 EGD92918.1 - 0.12 11.9 0.1 9.4 5.9 0.0 2.3 2 0 0 2 2 2 0 Partial alpha/beta-hydrolase lipase region Fungal_trans_2 PF11951.8 EGD92919.1 - 7.6e-06 25.0 0.0 1.2e-05 24.3 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain SLED PF12140.8 EGD92919.1 - 0.069 13.7 0.0 0.22 12.0 0.0 1.8 1 0 0 1 1 1 0 SLED domain RTA1 PF04479.13 EGD92920.1 - 2.7e-55 187.2 3.0 3.6e-55 186.8 3.0 1.2 1 0 0 1 1 1 1 RTA1 like protein Ribonuclease_3 PF00636.26 EGD92921.1 - 5.1e-14 52.8 0.1 4.2e-13 49.8 0.0 2.6 3 0 0 3 3 3 1 Ribonuclease III domain Ribonucleas_3_3 PF14622.6 EGD92921.1 - 2.5e-11 43.8 0.0 5.7e-11 42.7 0.0 1.7 1 0 0 1 1 1 1 Ribonuclease-III-like dsrm PF00035.26 EGD92921.1 - 0.16 12.7 0.1 0.16 12.7 0.1 2.3 2 0 0 2 2 2 0 Double-stranded RNA binding motif PLAC9 PF15205.6 EGD92921.1 - 0.17 12.3 0.0 0.33 11.4 0.0 1.5 1 0 0 1 1 1 0 Placenta-specific protein 9 Pannexin_like PF12534.8 EGD92921.1 - 0.23 10.5 3.8 0.37 9.8 3.8 1.2 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 MRP-S33 PF08293.11 EGD92922.1 - 7.6e-29 99.8 0.1 9.7e-29 99.5 0.1 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal subunit S27 DUF382 PF04037.13 EGD92923.1 - 3.8e-29 101.4 1.4 9.2e-29 100.2 0.0 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF382) ER_lumen_recept PF00810.18 EGD92925.1 - 2.9e-54 183.9 7.0 2.9e-54 183.9 7.0 1.6 2 0 0 2 2 2 1 ER lumen protein retaining receptor DUF485 PF04341.12 EGD92925.1 - 1 9.4 7.3 0.2 11.6 0.3 2.8 2 1 1 3 3 3 0 Protein of unknown function, DUF485 PQ-loop PF04193.14 EGD92925.1 - 1.3 8.8 15.9 0.75 9.6 0.2 4.4 4 1 1 5 5 5 0 PQ loop repeat Integrase_H2C2 PF17921.1 EGD92926.1 - 1.5e-07 31.4 0.8 1.5e-07 31.4 0.8 2.5 3 0 0 3 3 3 1 Integrase zinc binding domain XRCC4 PF06632.12 EGD92928.1 - 2e-10 40.1 16.4 4.8e-10 38.8 16.4 1.6 1 1 0 1 1 1 1 DNA double-strand break repair and V(D)J recombination protein XRCC4 DUF3585 PF12130.8 EGD92928.1 - 0.0093 16.1 3.7 0.0093 16.1 3.7 1.6 2 0 0 2 2 2 1 Bivalent Mical/EHBP Rab binding domain Baculo_gp64 PF03273.13 EGD92928.1 - 0.058 12.2 0.0 0.081 11.7 0.0 1.1 1 0 0 1 1 1 0 Baculovirus gp64 envelope glycoprotein family DUF4407 PF14362.6 EGD92928.1 - 0.98 8.7 14.7 0.38 10.1 12.2 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) ISG65-75 PF11727.8 EGD92928.1 - 1.1 8.4 9.0 1.1 8.4 7.8 1.6 1 1 1 2 2 2 0 Invariant surface glycoprotein SKA1 PF07160.12 EGD92928.1 - 1.5 8.6 13.1 0.048 13.5 7.1 1.5 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 1 Jnk-SapK_ap_N PF09744.9 EGD92928.1 - 2.3 8.5 10.9 0.27 11.5 5.4 2.0 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 V_ATPase_I PF01496.19 EGD92928.1 - 7 4.4 6.0 9.1 4.0 6.0 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Molybdopterin PF00384.22 EGD92929.1 - 2.1e-70 237.9 0.0 8.5e-68 229.3 0.0 2.1 1 1 0 1 1 1 1 Molybdopterin oxidoreductase NADH_dhqG_C PF09326.11 EGD92929.1 - 8.6e-19 68.0 0.0 2.1e-18 66.7 0.0 1.7 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase subunit G, C-terminal NADH-G_4Fe-4S_3 PF10588.9 EGD92929.1 - 2.8e-17 62.0 0.2 2.8e-17 62.0 0.2 2.2 2 0 0 2 2 2 1 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region Fer2_4 PF13510.6 EGD92929.1 - 2.9e-15 56.1 0.1 8.1e-15 54.6 0.1 1.8 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Fer2 PF00111.27 EGD92929.1 - 0.00011 22.0 1.8 0.00017 21.5 0.1 2.1 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain Fer4 PF00037.27 EGD92929.1 - 0.12 12.2 1.1 3.4 7.6 0.3 2.5 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_19 PF06902.11 EGD92929.1 - 0.25 11.5 2.0 4.8 7.3 2.0 2.6 1 1 0 1 1 1 0 Divergent 4Fe-4S mono-cluster TPT PF03151.16 EGD92930.1 - 1.8e-58 198.2 17.1 2.2e-58 197.9 17.1 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family PSII PF00421.19 EGD92930.1 - 4.1e-06 25.8 0.1 7.4e-06 24.9 0.1 1.4 1 0 0 1 1 1 1 Photosystem II protein EamA PF00892.20 EGD92930.1 - 7.5e-05 22.9 35.0 0.0016 18.6 12.2 2.8 2 1 0 2 2 2 2 EamA-like transporter family UAA PF08449.11 EGD92930.1 - 0.11 11.6 21.3 2.1 7.5 21.3 2.1 1 1 0 1 1 1 0 UAA transporter family Peptidase_S9 PF00326.21 EGD92931.1 - 4.8e-08 32.7 1.0 8.8e-08 31.9 1.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Esterase PF00756.20 EGD92931.1 - 0.0013 18.5 0.2 0.0032 17.2 0.2 1.6 1 0 0 1 1 1 1 Putative esterase PUF PF00806.19 EGD92932.1 - 8.1e-35 116.6 1.2 8.9e-06 25.1 0.0 8.8 9 0 0 9 9 9 7 Pumilio-family RNA binding repeat RraB PF06877.11 EGD92932.1 - 0.009 16.7 0.2 0.055 14.2 0.0 2.3 3 0 0 3 3 3 1 Regulator of ribonuclease activity B DUF5572 PF17733.1 EGD92933.1 - 4.8e-25 87.1 0.2 9.8e-25 86.1 0.2 1.6 1 0 0 1 1 1 1 Family of unknown function (DUF5572) Ssl1 PF04056.14 EGD92934.1 - 1.9e-73 246.4 0.0 2.6e-73 245.9 0.0 1.2 1 0 0 1 1 1 1 Ssl1-like C1_4 PF07975.12 EGD92934.1 - 3.4e-18 65.6 8.2 3.4e-18 65.6 8.2 2.4 2 1 0 2 2 2 1 TFIIH C1-like domain VWA_2 PF13519.6 EGD92934.1 - 4.5e-15 56.2 0.0 1e-14 55.0 0.0 1.6 2 0 0 2 2 2 1 von Willebrand factor type A domain Tfb4 PF03850.14 EGD92934.1 - 0.00062 19.4 3.5 0.00062 19.4 3.5 1.8 2 0 0 2 2 2 1 Transcription factor Tfb4 DZR PF12773.7 EGD92934.1 - 0.19 11.8 19.0 2.1 8.5 5.7 2.9 2 1 0 2 2 2 0 Double zinc ribbon YL1 PF05764.13 EGD92934.1 - 1.2 9.2 9.2 1.6 8.8 9.2 1.1 1 0 0 1 1 1 0 YL1 nuclear protein FYVE PF01363.21 EGD92934.1 - 4.6 7.5 18.8 0.027 14.6 5.4 2.6 2 0 0 2 2 2 0 FYVE zinc finger DUF4796 PF16044.5 EGD92934.1 - 9.7 5.7 14.4 1.2 8.7 5.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4796) ERAP1_C PF11838.8 EGD92935.1 - 6.4e-88 295.3 0.0 1.3e-87 294.3 0.0 1.5 1 0 0 1 1 1 1 ERAP1-like C-terminal domain Peptidase_M1 PF01433.20 EGD92935.1 - 5.5e-84 281.1 5.2 8.5e-84 280.5 5.2 1.3 1 0 0 1 1 1 1 Peptidase family M1 domain Peptidase_M1_N PF17900.1 EGD92935.1 - 3.7e-39 134.8 0.1 1.8e-38 132.6 0.0 2.1 2 0 0 2 2 2 1 Peptidase M1 N-terminal domain GlcNAc-1_reg PF18440.1 EGD92935.1 - 0.12 12.6 0.0 0.32 11.3 0.0 1.7 1 0 0 1 1 1 0 Putative GlcNAc-1 phosphotransferase regulatory domain Ras PF00071.22 EGD92936.1 - 1.2e-65 220.1 0.6 1.4e-65 219.8 0.6 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EGD92936.1 - 6.6e-36 123.2 0.2 1.2e-35 122.3 0.2 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EGD92936.1 - 1.6e-16 60.3 0.1 1.9e-16 60.0 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EGD92936.1 - 2.2e-05 24.5 0.0 9.2e-05 22.5 0.0 1.8 1 1 1 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EGD92936.1 - 2.3e-05 24.4 0.3 0.13 12.2 0.0 2.3 1 1 1 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 EGD92936.1 - 0.00015 21.4 0.4 0.00041 19.9 0.2 1.8 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EGD92936.1 - 0.00023 20.6 0.1 0.0003 20.2 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA PF00004.29 EGD92936.1 - 0.00043 20.7 0.0 0.18 12.3 0.0 2.2 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) SRPRB PF09439.10 EGD92936.1 - 0.00086 18.8 0.0 0.0013 18.2 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit FeoB_N PF02421.18 EGD92936.1 - 0.0042 16.6 0.1 0.023 14.2 0.1 1.9 1 1 0 1 1 1 1 Ferrous iron transport protein B AAA_16 PF13191.6 EGD92936.1 - 0.0085 16.5 0.0 0.011 16.1 0.0 1.3 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EGD92936.1 - 0.026 14.8 0.0 0.067 13.5 0.0 2.0 1 1 0 1 1 1 0 AAA domain Septin PF00735.18 EGD92936.1 - 0.033 13.5 0.1 0.18 11.1 0.0 1.9 2 0 0 2 2 2 0 Septin AAA_29 PF13555.6 EGD92936.1 - 0.054 13.2 0.0 0.15 11.8 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_tran PF00005.27 EGD92936.1 - 0.064 13.8 0.1 0.15 12.6 0.1 1.8 1 1 0 1 1 1 0 ABC transporter TniB PF05621.11 EGD92936.1 - 0.067 12.6 0.0 0.21 11.0 0.0 1.8 2 0 0 2 2 2 0 Bacterial TniB protein AAA_5 PF07728.14 EGD92936.1 - 0.072 13.1 0.1 0.2 11.6 0.0 1.7 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_25 PF13481.6 EGD92936.1 - 0.076 12.6 0.0 2.2 7.8 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 EGD92936.1 - 0.082 12.4 0.0 0.18 11.3 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region PduV-EutP PF10662.9 EGD92936.1 - 0.089 12.5 0.1 1.2 8.8 0.0 2.3 1 1 1 2 2 2 0 Ethanolamine utilisation - propanediol utilisation EIIBC-GUT_N PF03612.14 EGD92938.1 - 0.19 11.5 3.5 0.32 10.7 3.5 1.3 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Mito_carr PF00153.27 EGD92939.1 - 3.1e-56 187.3 1.9 2.8e-18 65.6 0.0 3.1 2 1 1 3 3 3 3 Mitochondrial carrier protein HMD PF03201.16 EGD92939.1 - 0.043 14.0 0.0 5.4 7.3 0.0 3.5 4 1 0 4 4 4 0 H2-forming N5,N10-methylene-tetrahydromethanopterin dehydrogenase Arteri_Gl PF00951.18 EGD92939.1 - 0.11 12.4 0.3 0.3 10.9 0.0 1.9 2 0 0 2 2 2 0 Arterivirus GL envelope glycoprotein DUF3278 PF11683.8 EGD92939.1 - 0.11 12.6 0.0 0.33 11.0 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3278) TadE PF07811.12 EGD92939.1 - 0.52 10.6 4.0 3.3 8.1 0.3 2.9 2 0 0 2 2 2 0 TadE-like protein WD40 PF00400.32 EGD92940.1 - 0.00032 21.5 17.2 1.2 10.1 0.0 7.1 8 0 0 8 8 8 3 WD domain, G-beta repeat UPF0029 PF01205.19 EGD92941.1 - 8.9e-36 122.4 0.0 1.5e-35 121.7 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized protein family UPF0029 RWD PF05773.22 EGD92941.1 - 0.00092 19.5 0.0 0.0018 18.6 0.0 1.5 1 0 0 1 1 1 1 RWD domain Glyco_hydro_61 PF03443.14 EGD92942.1 - 6.3e-05 23.0 0.0 0.00011 22.3 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 Ribosomal_L4 PF00573.22 EGD92944.1 - 5.2e-36 124.1 0.2 7e-36 123.7 0.2 1.2 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family Ribos_L4_asso_C PF14374.6 EGD92944.1 - 5.6e-30 103.2 1.2 9.4e-30 102.5 0.4 1.8 2 0 0 2 2 2 1 60S ribosomal protein L4 C-terminal domain DSPc PF00782.20 EGD92945.1 - 5.9e-23 81.1 0.0 7.1e-23 80.9 0.0 1.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EGD92945.1 - 0.0022 17.6 0.0 0.0079 15.8 0.0 1.7 2 0 0 2 2 2 1 Protein-tyrosine phosphatase Init_tRNA_PT PF04179.12 EGD92945.1 - 0.029 14.7 0.0 0.043 14.1 0.0 1.2 1 0 0 1 1 1 0 Rit1 DUSP-like domain PTPlike_phytase PF14566.6 EGD92945.1 - 0.09 12.9 0.0 0.14 12.3 0.0 1.3 1 0 0 1 1 1 0 Inositol hexakisphosphate SIS_2 PF13580.6 EGD92945.1 - 0.09 12.8 0.0 0.21 11.6 0.0 1.6 2 0 0 2 2 2 0 SIS domain DUF1877 PF08974.10 EGD92945.1 - 0.17 12.0 0.0 0.22 11.6 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1877) BCS1_N PF08740.11 EGD92946.1 - 1.5e-40 139.1 2.6 3e-40 138.2 2.6 1.5 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.29 EGD92946.1 - 3e-17 63.3 0.0 3.9e-15 56.5 0.0 2.5 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EGD92946.1 - 0.0048 17.3 0.0 0.093 13.1 0.0 2.8 1 1 1 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 EGD92946.1 - 0.0083 15.9 0.0 0.017 14.9 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain ATPase PF06745.13 EGD92946.1 - 0.028 13.8 0.0 0.053 12.9 0.0 1.4 1 0 0 1 1 1 0 KaiC AAA_5 PF07728.14 EGD92946.1 - 0.09 12.8 0.0 0.39 10.7 0.0 2.1 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) NAAA-beta PF15508.6 EGD92947.1 - 1.4e-11 44.5 0.1 2.9e-11 43.5 0.1 1.5 1 0 0 1 1 1 1 beta subunit of N-acylethanolamine-hydrolyzing acid amidase DUF3395 PF11875.8 EGD92948.1 - 2e-40 138.2 0.0 4.2e-40 137.2 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3395) DnaJ PF00226.31 EGD92948.1 - 3.3e-16 59.2 0.1 7.6e-16 58.0 0.1 1.7 1 0 0 1 1 1 1 DnaJ domain KOG2701 PF09762.9 EGD92948.1 - 0.023 14.9 0.2 0.067 13.4 0.2 1.7 1 0 0 1 1 1 0 Coiled-coil domain-containing protein (DUF2037) SKIP_SNW PF02731.15 EGD92950.1 - 7.7e-72 240.2 5.7 7.7e-72 240.2 5.7 2.3 3 0 0 3 3 3 1 SKIP/SNW domain Nucleo_P87 PF07267.11 EGD92950.1 - 2.2 7.1 11.5 5.1 5.8 11.5 1.6 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 Borrelia_P83 PF05262.11 EGD92950.1 - 2.8 6.3 14.4 5.7 5.3 14.4 1.5 1 0 0 1 1 1 0 Borrelia P83/100 protein WD40 PF00400.32 EGD92951.1 - 8.6e-38 127.7 32.8 1.6e-09 38.2 0.9 12.9 13 0 0 13 13 13 7 WD domain, G-beta repeat Utp12 PF04003.12 EGD92951.1 - 1.8e-27 95.7 0.0 2.9e-27 95.1 0.0 1.3 1 0 0 1 1 1 1 Dip2/Utp12 Family ANAPC4_WD40 PF12894.7 EGD92951.1 - 3.9e-22 78.3 0.0 0.0073 16.6 0.0 9.4 5 2 5 11 11 11 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EGD92951.1 - 2.6e-09 36.5 0.2 0.28 10.1 0.0 5.1 3 2 2 5 5 5 4 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 EGD92951.1 - 5.4e-07 29.7 0.7 0.0089 15.9 0.1 4.9 5 1 0 6 6 6 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 EGD92951.1 - 5.3e-06 25.4 4.6 0.65 8.6 0.0 4.9 2 2 1 4 4 4 3 Nucleoporin Nup120/160 ELYS-bb PF16687.5 EGD92951.1 - 0.0017 17.1 0.1 0.03 12.9 0.0 2.7 3 1 1 4 4 4 1 beta-propeller of ELYS nucleoporin WD40_like PF17005.5 EGD92951.1 - 0.0031 16.9 0.0 2 7.7 0.0 3.7 4 0 0 4 4 4 1 WD40-like domain PQQ_3 PF13570.6 EGD92951.1 - 0.028 14.9 0.9 60 4.3 0.0 4.8 4 0 0 4 4 4 0 PQQ-like domain Pox_T4_N PF04491.12 EGD92951.1 - 0.045 13.6 0.4 0.26 11.2 0.1 2.2 2 0 0 2 2 2 0 Poxvirus T4 protein, N terminus Septin PF00735.18 EGD92952.1 - 1.4e-112 375.6 0.3 2.1e-112 375.0 0.3 1.3 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 EGD92952.1 - 1.4e-07 31.6 0.0 3e-07 30.5 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EGD92952.1 - 4.9e-06 26.2 2.4 0.00016 21.2 0.1 2.6 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EGD92952.1 - 6.7e-06 26.1 1.1 5.7e-05 23.1 0.0 2.7 3 0 0 3 3 3 1 RsgA GTPase AAA_22 PF13401.6 EGD92952.1 - 0.0021 18.3 0.6 0.0074 16.6 0.0 2.2 2 1 0 2 2 2 1 AAA domain Pox_A32 PF04665.12 EGD92952.1 - 0.0028 17.2 0.1 0.0052 16.3 0.1 1.4 1 0 0 1 1 1 1 Poxvirus A32 protein Roc PF08477.13 EGD92952.1 - 0.0059 16.8 0.0 0.013 15.7 0.0 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase AIG1 PF04548.16 EGD92952.1 - 0.0059 15.9 0.0 0.011 15.0 0.0 1.5 1 0 0 1 1 1 1 AIG1 family IIGP PF05049.13 EGD92952.1 - 0.0085 15.2 0.0 0.016 14.3 0.0 1.5 1 0 0 1 1 1 1 Interferon-inducible GTPase (IIGP) Casc1_N PF15927.5 EGD92952.1 - 0.012 15.3 10.5 0.032 13.9 10.5 1.6 1 0 0 1 1 1 0 Cancer susceptibility candidate 1 N-terminus AAA_24 PF13479.6 EGD92952.1 - 0.014 15.1 0.0 0.027 14.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 EGD92952.1 - 0.023 14.3 0.4 0.17 11.4 0.0 2.3 2 0 0 2 2 2 0 AAA domain FOXP-CC PF16159.5 EGD92952.1 - 0.027 15.1 2.3 0.041 14.5 0.8 2.1 1 1 1 2 2 1 0 FOXP coiled-coil domain AAA_16 PF13191.6 EGD92952.1 - 0.031 14.7 1.3 0.083 13.3 0.1 2.4 2 1 0 2 2 2 0 AAA ATPase domain KAP_NTPase PF07693.14 EGD92952.1 - 0.037 13.3 0.0 0.046 13.0 0.0 1.5 1 1 0 1 1 1 0 KAP family P-loop domain T2SSE PF00437.20 EGD92952.1 - 0.042 12.9 0.4 0.12 11.5 0.0 1.8 2 0 0 2 2 2 0 Type II/IV secretion system protein Ras PF00071.22 EGD92952.1 - 0.043 13.4 0.3 0.12 12.0 0.3 1.8 1 1 0 1 1 1 0 Ras family NACHT PF05729.12 EGD92952.1 - 0.052 13.5 0.0 0.1 12.5 0.0 1.5 1 0 0 1 1 1 0 NACHT domain ABC_tran PF00005.27 EGD92952.1 - 0.06 13.9 0.1 0.3 11.6 0.0 2.1 2 0 0 2 2 2 0 ABC transporter Sigma54_activat PF00158.26 EGD92952.1 - 0.097 12.4 0.0 0.19 11.4 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain PduV-EutP PF10662.9 EGD92952.1 - 0.15 11.8 0.4 5.4 6.8 0.4 2.6 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation ATP_bind_1 PF03029.17 EGD92952.1 - 0.26 11.0 0.7 14 5.4 0.1 2.6 1 1 0 2 2 2 0 Conserved hypothetical ATP binding protein Dynamin_N PF00350.23 EGD92952.1 - 0.36 10.9 5.4 6.1 6.9 0.0 3.2 2 1 1 3 3 3 0 Dynamin family DegS PF05384.11 EGD92952.1 - 4.1 6.9 12.4 2 7.9 7.4 2.6 2 1 1 3 3 3 0 Sensor protein DegS WD40 PF00400.32 EGD92953.1 - 9.3e-21 73.8 15.8 6.7e-05 23.6 0.5 6.4 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EGD92953.1 - 1.7e-09 37.8 0.2 0.021 15.1 0.0 4.4 2 1 4 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain PQQ PF01011.21 EGD92953.1 - 4e-07 29.6 2.1 0.016 15.1 0.0 4.3 5 0 0 5 5 5 2 PQQ enzyme repeat Ge1_WD40 PF16529.5 EGD92953.1 - 0.021 13.8 1.1 0.93 8.4 0.0 3.3 2 1 1 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein VID27 PF08553.10 EGD92953.1 - 0.024 13.7 0.0 0.078 12.0 0.1 1.9 2 1 0 2 2 2 0 VID27 C-terminal WD40-like domain BBS2_Mid PF14783.6 EGD92953.1 - 0.11 12.5 0.0 0.96 9.5 0.0 2.6 3 1 0 3 3 3 0 Ciliary BBSome complex subunit 2, middle region ACT_7 PF13840.6 EGD92954.1 - 1.4e-23 82.4 0.4 8.9e-16 57.4 0.1 2.4 2 1 0 2 2 2 2 ACT domain XRN_M PF17846.1 EGD92955.1 - 2.5e-98 330.0 2.0 4.7e-98 329.0 2.0 1.4 1 0 0 1 1 1 1 Xrn1 helical domain XRN_N PF03159.18 EGD92955.1 - 1.3e-97 326.0 0.0 2e-97 325.4 0.0 1.3 1 0 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus XRN1_D1 PF18332.1 EGD92955.1 - 1.1e-73 247.1 2.6 1.5e-73 246.7 0.1 2.1 2 0 0 2 2 2 1 Exoribonuclease Xrn1 D1 domain XRN1_D2_D3 PF18334.1 EGD92955.1 - 4.5e-33 113.3 0.0 1.1e-32 112.0 0.0 1.8 1 0 0 1 1 1 1 Exoribonuclease Xrn1 D2/D3 domain SH3_12 PF18129.1 EGD92955.1 - 4.6e-23 81.1 0.1 1.2e-22 79.8 0.1 1.8 1 0 0 1 1 1 1 Xrn1 SH3-like domain Xrn1_D3 PF18194.1 EGD92955.1 - 1.1e-09 38.2 0.5 2.7e-09 37.0 0.5 1.7 1 0 0 1 1 1 1 Exoribonuclease 1 Domain-3 DUF2207 PF09972.9 EGD92955.1 - 0.084 11.6 0.7 0.15 10.8 0.7 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) RXLR PF16810.5 EGD92955.1 - 0.64 10.5 2.4 1.3 9.4 2.4 1.4 1 0 0 1 1 1 0 RXLR phytopathogen effector protein, Avirulence activity Cwf_Cwc_15 PF04889.12 EGD92955.1 - 2 8.1 7.8 3.8 7.2 7.8 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein CAF1C_H4-bd PF12265.8 EGD92956.1 - 7.4e-30 103.0 0.8 5.6e-29 100.2 1.0 2.4 2 0 0 2 2 2 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 EGD92956.1 - 4.1e-28 97.1 8.2 3e-05 24.7 0.1 6.3 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EGD92956.1 - 1.3e-06 28.5 1.2 0.14 12.5 0.1 4.4 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain GTP_cyclohydroI PF01227.22 EGD92957.1 - 6.2e-73 244.0 0.3 8.9e-73 243.5 0.3 1.2 1 0 0 1 1 1 1 GTP cyclohydrolase I QueF PF14489.6 EGD92957.1 - 0.0011 19.1 0.0 0.0022 18.1 0.0 1.4 1 0 0 1 1 1 1 QueF-like protein Cu_amine_oxidN2 PF02727.16 EGD92957.1 - 0.082 13.1 0.0 0.25 11.6 0.0 1.8 1 0 0 1 1 1 0 Copper amine oxidase, N2 domain Questin_oxidase PF14027.6 EGD92959.1 - 3.4e-96 322.7 0.5 4.1e-96 322.5 0.5 1.1 1 0 0 1 1 1 1 Questin oxidase-like Lactamase_B_5 PF14597.6 EGD92959.1 - 0.0039 16.7 0.0 0.0065 16.0 0.0 1.2 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Thymidylate_kin PF02223.17 EGD92959.1 - 0.16 11.6 0.0 0.36 10.5 0.0 1.5 1 0 0 1 1 1 0 Thymidylate kinase Pkinase PF00069.25 EGD92960.1 - 2.5e-70 236.9 0.0 3.5e-70 236.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD92960.1 - 1.9e-32 112.6 0.0 3.4e-32 111.8 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EGD92960.1 - 0.00035 20.0 0.5 0.00077 18.9 0.5 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EGD92960.1 - 0.001 18.4 0.2 0.0054 16.1 0.0 1.9 1 1 1 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 EGD92960.1 - 0.031 13.0 0.0 0.031 13.0 0.0 2.6 4 0 0 4 4 4 0 Fungal protein kinase Haspin_kinase PF12330.8 EGD92960.1 - 0.21 10.5 0.0 0.21 10.5 0.0 2.0 3 0 0 3 3 3 0 Haspin like kinase domain NUDIX PF00293.28 EGD92961.1 - 3.2e-16 59.6 0.0 6.1e-16 58.7 0.0 1.4 1 0 0 1 1 1 1 NUDIX domain NUDIX-like PF09296.11 EGD92961.1 - 6e-15 55.7 0.0 3e-14 53.5 0.0 2.1 3 0 0 3 3 3 1 NADH pyrophosphatase-like rudimentary NUDIX domain DUF5447 PF17525.2 EGD92961.1 - 0.0028 18.1 1.4 6.2 7.4 0.5 3.4 3 0 0 3 3 3 1 Family of unknown function (DUF5447) zf-NADH-PPase PF09297.11 EGD92961.1 - 0.0042 16.7 1.3 0.0069 16.0 1.3 1.3 1 0 0 1 1 1 1 NADH pyrophosphatase zinc ribbon domain 120_Rick_ant PF12574.8 EGD92961.1 - 0.14 11.3 0.0 0.22 10.7 0.0 1.2 1 0 0 1 1 1 0 120 KDa Rickettsia surface antigen MPM1 PF17234.2 EGD92962.1 - 0.084 13.1 4.3 0.18 12.0 4.3 1.6 1 0 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 G_path_suppress PF15991.5 EGD92962.1 - 1.2 9.2 11.2 0.43 10.7 7.2 2.1 2 0 0 2 2 2 0 G-protein pathway suppressor Dynamin_N PF00350.23 EGD92963.1 - 2e-20 73.5 0.0 5e-20 72.2 0.0 1.7 1 0 0 1 1 1 1 Dynamin family Dynamin_M PF01031.20 EGD92963.1 - 7.2e-14 51.7 0.0 2.8e-13 49.7 0.0 2.0 1 1 0 1 1 1 1 Dynamin central region FeoB_N PF02421.18 EGD92963.1 - 4.8e-05 22.9 0.4 0.031 13.8 0.1 2.6 2 0 0 2 2 2 2 Ferrous iron transport protein B MMR_HSR1 PF01926.23 EGD92963.1 - 0.00017 21.6 0.0 0.0015 18.6 0.0 2.5 2 1 0 2 2 2 1 50S ribosome-binding GTPase GED PF02212.18 EGD92963.1 - 0.013 15.6 0.6 0.05 13.8 0.1 2.2 2 0 0 2 2 2 0 Dynamin GTPase effector domain AAA_23 PF13476.6 EGD92963.1 - 0.016 15.7 0.8 0.42 11.1 0.0 2.9 3 0 0 3 3 3 0 AAA domain AAA_15 PF13175.6 EGD92963.1 - 0.024 14.4 1.2 0.27 10.9 0.0 2.5 3 0 0 3 3 3 0 AAA ATPase domain EF-G-binding_N PF07299.11 EGD92963.1 - 0.083 13.4 0.2 0.36 11.4 0.2 2.2 1 0 0 1 1 1 0 Elongation factor G-binding protein, N-terminal TetR_C_16 PF17920.1 EGD92963.1 - 0.099 12.9 0.0 0.32 11.2 0.0 1.9 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain Striatin PF08232.12 EGD92963.1 - 1.6 9.3 3.9 3 8.4 3.3 1.8 2 0 0 2 2 2 0 Striatin family ERCC3_RAD25_C PF16203.5 EGD92964.1 - 1.2e-122 407.9 0.7 2e-122 407.1 0.7 1.3 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase Helicase_C_3 PF13625.6 EGD92964.1 - 8.1e-34 116.5 0.0 3.3e-33 114.5 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EGD92964.1 - 1.8e-14 54.1 0.0 4e-14 53.0 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EGD92964.1 - 7.3e-14 52.1 0.1 1.7e-13 50.9 0.1 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SNF2_N PF00176.23 EGD92964.1 - 2.6e-07 29.7 0.0 3.5e-07 29.3 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain AAA_34 PF13872.6 EGD92964.1 - 0.00093 18.2 0.0 0.0015 17.5 0.0 1.3 1 0 0 1 1 1 1 P-loop containing NTP hydrolase pore-1 DUF4677 PF15726.5 EGD92964.1 - 0.075 13.2 1.1 0.16 12.1 1.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4677) DUF4748 PF15932.5 EGD92965.1 - 4.8e-23 80.7 0.9 4.8e-23 80.7 0.9 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4748) CTD_bind PF04818.13 EGD92968.1 - 1.3e-10 42.0 0.0 2.9e-10 40.8 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase II-binding domain. SOBP PF15279.6 EGD92968.1 - 0.002 18.8 22.6 0.002 18.8 22.6 2.2 2 0 0 2 2 2 1 Sine oculis-binding protein EMP24_GP25L PF01105.24 EGD92969.1 - 2.7e-44 151.3 0.2 3.2e-44 151.0 0.2 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD USP7_ICP0_bdg PF12436.8 EGD92970.1 - 5.5e-87 291.0 0.0 6.2e-86 287.6 0.0 2.2 2 0 0 2 2 2 1 ICP0-binding domain of Ubiquitin-specific protease 7 USP7_C2 PF14533.6 EGD92970.1 - 1.6e-71 240.3 0.9 6.5e-71 238.3 0.6 2.1 2 0 0 2 2 2 1 Ubiquitin-specific protease C-terminal UCH PF00443.29 EGD92970.1 - 1.6e-45 155.6 0.2 2.6e-45 154.9 0.2 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EGD92970.1 - 5.3e-21 75.5 0.0 1.2e-20 74.4 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase MATH PF00917.26 EGD92970.1 - 1.2e-07 31.9 0.1 4.3e-07 30.1 0.0 2.0 2 0 0 2 2 2 1 MATH domain Rad60-SLD PF11976.8 EGD92970.1 - 0.12 12.3 0.9 2.2 8.2 0.0 3.5 4 1 0 4 4 4 0 Ubiquitin-2 like Rad60 SUMO-like BCDHK_Adom3 PF10436.9 EGD92971.1 - 5.7e-45 153.1 0.1 1.2e-44 152.0 0.0 1.6 2 0 0 2 2 2 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 EGD92971.1 - 3.3e-06 27.6 0.0 1.7e-05 25.3 0.0 2.0 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 EGD92971.1 - 0.18 11.6 0.0 0.33 10.8 0.0 1.4 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_2 PF13581.6 EGD92971.1 - 0.19 11.7 0.0 2.3 8.2 0.0 2.2 2 0 0 2 2 2 0 Histidine kinase-like ATPase domain Pmp3 PF01679.17 EGD92972.1 - 6.1e-19 68.0 8.2 7.9e-19 67.6 8.2 1.2 1 0 0 1 1 1 1 Proteolipid membrane potential modulator SPC22 PF04573.12 EGD92973.1 - 1.5e-39 135.2 0.6 3.7e-37 127.4 0.6 2.1 1 1 0 1 1 1 1 Signal peptidase subunit Peptidase_C48 PF02902.19 EGD92974.1 - 5.4e-32 111.4 0.3 1e-30 107.2 0.3 2.4 1 1 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain IF4E PF01652.18 EGD92975.1 - 5.4e-55 185.5 0.1 8.7e-55 184.9 0.1 1.3 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E Aminotran_1_2 PF00155.21 EGD92977.1 - 3.2e-27 95.7 0.0 3.9e-27 95.4 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_3 PF00202.21 EGD92977.1 - 0.00091 18.0 0.0 0.033 12.9 0.0 2.1 2 0 0 2 2 2 2 Aminotransferase class-III POT1 PF02765.17 EGD92978.1 - 9.2e-18 64.4 0.0 1.7e-17 63.6 0.0 1.5 1 0 0 1 1 1 1 Telomeric single stranded DNA binding POT1/CDC13 zf-C2H2 PF00096.26 EGD92979.1 - 1e-12 47.7 45.5 0.015 15.8 1.3 6.7 6 0 0 6 6 6 5 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EGD92979.1 - 2.5e-12 46.6 46.1 0.0033 17.8 1.5 6.7 7 0 0 7 7 7 5 Zinc-finger double domain zf-C2H2_4 PF13894.6 EGD92979.1 - 2.3e-09 37.3 41.7 0.15 13.0 1.9 6.8 6 0 0 6 6 6 5 C2H2-type zinc finger zf-C2H2_3rep PF18868.1 EGD92979.1 - 0.011 16.4 16.7 0.14 12.8 3.0 3.4 1 1 2 3 3 3 0 Zinc finger C2H2-type, 3 repeats FXa_inhibition PF14670.6 EGD92979.1 - 0.016 15.4 8.8 7 7.0 0.1 4.2 4 0 0 4 4 4 0 Coagulation Factor Xa inhibitory site zf-TRAF PF02176.18 EGD92979.1 - 0.11 13.2 19.6 2 9.2 1.0 4.5 1 1 4 5 5 5 0 TRAF-type zinc finger zinc_ribbon_15 PF17032.5 EGD92979.1 - 0.13 13.0 26.4 0.25 12.1 3.8 3.7 1 1 5 6 6 6 0 zinc-ribbon family ARS2 PF04959.13 EGD92979.1 - 0.28 11.6 20.3 0.64 10.4 0.6 4.7 2 2 3 5 5 5 0 Arsenite-resistance protein 2 FhuF_C PF11575.8 EGD92979.1 - 0.4 10.7 6.7 81 3.3 0.1 4.6 4 0 0 4 4 4 0 FhuF 2Fe-2S C-terminal domain zf-met PF12874.7 EGD92979.1 - 0.9 10.0 23.0 1.9 9.0 0.4 6.6 7 0 0 7 7 7 0 Zinc-finger of C2H2 type Ephrin_rec_like PF07699.13 EGD92979.1 - 1.4 8.8 25.2 1.8 8.4 6.3 4.3 2 1 2 4 4 4 0 Putative ephrin-receptor like NCD3G PF07562.14 EGD92979.1 - 4.5 7.3 26.4 0.74 9.8 5.7 4.3 1 1 4 5 5 5 0 Nine Cysteines Domain of family 3 GPCR DUF2841 PF11001.8 EGD92980.1 - 8.2e-48 161.6 0.1 1.3e-47 160.9 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2841) SWI-SNF_Ssr4 PF08549.10 EGD92982.1 - 0.027 13.1 6.2 0.057 12.1 6.2 1.4 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) DUF1590 PF07629.11 EGD92983.1 - 0.033 14.0 0.1 0.065 13.1 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1590) EST1_DNA_bind PF10373.9 EGD92984.1 - 0.00062 19.3 0.1 0.0017 17.9 0.2 1.7 2 0 0 2 2 2 1 Est1 DNA/RNA binding domain DnaB PF00772.21 EGD92986.1 - 0.038 14.1 0.1 0.091 12.8 0.1 1.6 1 0 0 1 1 1 0 DnaB-like helicase N terminal domain Cu_bind_like PF02298.17 EGD92987.1 - 0.092 12.8 0.1 0.27 11.3 0.1 1.8 1 1 0 1 1 1 0 Plastocyanin-like domain zf-RING_2 PF13639.6 EGD92989.1 - 7.4e-10 39.0 11.8 3.5e-08 33.6 9.1 2.6 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 EGD92989.1 - 3.4e-06 26.8 9.9 0.003 17.4 7.9 2.6 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EGD92989.1 - 0.0007 19.8 10.2 0.0074 16.6 8.1 2.6 2 0 0 2 2 2 1 RING-H2 zinc finger domain Zn_ribbon_17 PF17120.5 EGD92989.1 - 0.0027 17.3 6.9 0.0027 17.3 6.9 2.1 2 0 0 2 2 2 1 Zinc-ribbon, C4HC2 type zf-RING-like PF08746.11 EGD92989.1 - 0.051 13.9 10.2 0.1 12.9 10.2 1.5 1 0 0 1 1 1 0 RING-like domain zf-C3HC4 PF00097.25 EGD92989.1 - 0.055 13.4 14.9 0.38 10.7 0.0 3.4 3 1 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EGD92989.1 - 0.081 12.9 11.1 5.5 7.0 0.0 2.5 2 0 0 2 2 2 0 zinc-RING finger domain C1_1 PF00130.22 EGD92989.1 - 0.3 11.0 8.1 0.045 13.6 3.2 2.0 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Zf_RING PF16744.5 EGD92989.1 - 0.56 10.4 4.1 1.1 9.5 2.8 2.1 2 0 0 2 2 2 0 KIAA1045 RING finger FANCL_C PF11793.8 EGD92989.1 - 0.58 10.4 15.3 0.66 10.2 12.0 2.7 2 1 0 2 2 2 0 FANCL C-terminal domain PHD PF00628.29 EGD92989.1 - 0.8 9.6 8.0 2.3 8.2 8.0 1.9 1 0 0 1 1 1 0 PHD-finger RINGv PF12906.7 EGD92989.1 - 1.6 8.9 8.7 4.2 7.6 8.7 1.7 1 0 0 1 1 1 0 RING-variant domain zf-C5HC2 PF02928.16 EGD92989.1 - 1.9 8.9 5.5 6 7.3 5.5 1.8 1 0 0 1 1 1 0 C5HC2 zinc finger zf-ANAPC11 PF12861.7 EGD92989.1 - 2.9 8.0 9.6 3.5 7.7 6.3 2.7 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger Pkinase PF00069.25 EGD92990.1 - 0.0018 17.7 0.0 0.0032 16.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.23 EGD92990.1 - 0.033 14.1 0.0 0.069 13.1 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase PF00069.25 EGD92991.1 - 2.2e-08 33.8 0.1 4e-08 32.9 0.1 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD92991.1 - 2.3e-06 27.1 0.1 3.2e-06 26.6 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Ferric_reduct PF01794.19 EGD92992.1 - 3.4e-10 40.1 27.9 1.6e-09 37.9 10.6 3.3 2 1 1 3 3 3 2 Ferric reductase like transmembrane component FAD_binding_8 PF08022.12 EGD92992.1 - 1.3e-09 38.1 0.0 2.9e-09 37.0 0.0 1.5 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_6 PF08030.12 EGD92992.1 - 9.6e-05 22.6 0.0 0.0002 21.5 0.0 1.6 1 0 0 1 1 1 1 Ferric reductase NAD binding domain DUF948 PF06103.11 EGD92992.1 - 2.7 8.3 4.6 1.3 9.3 0.1 2.5 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) DUF3723 PF12520.8 EGD92993.1 - 5e-166 553.3 0.0 5e-166 553.3 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF3723) DUF3552 PF12072.8 EGD92993.1 - 0.00085 18.8 72.2 0.003 17.0 31.9 3.2 2 1 1 3 3 3 2 Domain of unknown function (DUF3552) DUF390 PF04094.14 EGD92993.1 - 0.2 9.9 8.1 0.31 9.3 8.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF390) YlqD PF11068.8 EGD92994.1 - 1.1 9.6 12.4 9.4 6.6 0.3 2.5 2 1 0 2 2 2 0 YlqD protein Pkinase PF00069.25 EGD92996.1 - 0.097 12.0 0.0 0.52 9.6 0.0 1.9 2 0 0 2 2 2 0 Protein kinase domain UPF0270 PF06794.12 EGD92999.1 - 0.049 13.7 0.0 0.11 12.6 0.0 1.5 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0270) DUF3435 PF11917.8 EGD93000.1 - 0.0032 16.5 0.0 0.0039 16.2 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3435) FMO-like PF00743.19 EGD93002.1 - 1.2e-36 126.2 0.0 1.7e-22 79.5 0.0 2.6 2 1 0 3 3 3 2 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 EGD93002.1 - 3.5e-11 42.9 0.0 5.2e-09 35.8 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EGD93002.1 - 2.6e-06 26.9 0.0 5e-06 26.0 0.0 1.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EGD93002.1 - 2.9e-05 23.4 0.0 0.00013 21.2 0.0 1.8 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) HDA2-3 PF11496.8 EGD93003.1 - 8.1e-37 127.0 1.3 5.8e-18 65.1 0.0 2.8 3 1 0 3 3 3 2 Class II histone deacetylase complex subunits 2 and 3 DUF745 PF05335.13 EGD93003.1 - 0.0024 17.6 21.1 0.0088 15.8 6.7 2.7 2 0 0 2 2 2 2 Protein of unknown function (DUF745) Glutaredoxin2_C PF04399.13 EGD93003.1 - 0.47 10.3 2.7 24 4.8 0.1 3.2 2 0 0 2 2 2 0 Glutaredoxin 2, C terminal domain Med9 PF07544.13 EGD93003.1 - 1.1 9.4 21.3 0.2 11.8 1.3 4.0 2 2 1 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 ADIP PF11559.8 EGD93003.1 - 3.1 7.9 38.8 1.1 9.3 15.6 3.4 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding DUF1664 PF07889.12 EGD93003.1 - 3.3 7.8 15.6 1.7 8.7 3.2 3.5 2 1 2 4 4 4 0 Protein of unknown function (DUF1664) GAS PF13851.6 EGD93003.1 - 5.4 6.3 33.3 2.6 7.4 3.1 2.7 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding Fib_alpha PF08702.10 EGD93003.1 - 6.1 7.0 22.5 7.6 6.7 8.4 3.3 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family DUF4407 PF14362.6 EGD93003.1 - 6.6 6.0 32.4 0.07 12.5 17.4 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) MIP PF00230.20 EGD93004.1 - 1e-44 153.0 12.6 1.3e-44 152.7 12.6 1.0 1 0 0 1 1 1 1 Major intrinsic protein Transglut_core PF01841.19 EGD93006.1 - 4e-11 43.4 0.2 1e-10 42.0 0.2 1.8 2 0 0 2 2 2 1 Transglutaminase-like superfamily SH3_2 PF07653.17 EGD93006.1 - 1.5e-08 34.2 0.1 3.7e-08 32.9 0.1 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EGD93006.1 - 1.2e-05 24.9 0.1 1.2e-05 24.9 0.1 2.2 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 EGD93006.1 - 0.00061 19.6 0.1 0.011 15.5 0.1 2.5 2 0 0 2 2 2 1 Variant SH3 domain Transglut_core2 PF13369.6 EGD93006.1 - 0.065 12.8 0.1 0.14 11.8 0.1 1.4 1 0 0 1 1 1 0 Transglutaminase-like superfamily DHHA2 PF02833.14 EGD93007.1 - 3.6e-34 118.0 0.1 6.4e-34 117.2 0.1 1.4 1 0 0 1 1 1 1 DHHA2 domain DHH PF01368.20 EGD93007.1 - 9.9e-06 25.7 0.0 6.9e-05 23.0 0.0 2.4 1 1 0 1 1 1 1 DHH family PLU-1 PF08429.11 EGD93008.1 - 7.6e-110 367.2 15.6 1.4e-107 359.8 14.1 2.2 2 0 0 2 2 2 2 PLU-1-like protein JmjC PF02373.22 EGD93008.1 - 2.3e-42 144.0 1.0 6.5e-42 142.6 0.4 2.2 2 0 0 2 2 2 1 JmjC domain, hydroxylase ARID PF01388.21 EGD93008.1 - 8.2e-22 77.7 0.1 2.5e-21 76.1 0.1 1.9 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain JmjN PF02375.17 EGD93008.1 - 1.5e-18 66.4 3.2 3.7e-18 65.2 3.2 1.8 1 0 0 1 1 1 1 jmjN domain PHD PF00628.29 EGD93008.1 - 5e-18 64.7 28.0 6.4e-10 38.8 7.0 3.7 3 0 0 3 3 3 2 PHD-finger zf-C5HC2 PF02928.16 EGD93008.1 - 7.7e-12 45.4 5.4 2.2e-11 44.0 5.4 1.9 1 0 0 1 1 1 1 C5HC2 zinc finger PHD_2 PF13831.6 EGD93008.1 - 0.0041 16.6 2.0 0.0041 16.6 2.0 2.9 2 0 0 2 2 2 1 PHD-finger zf-PHD-like PF15446.6 EGD93008.1 - 0.17 11.5 15.1 0.043 13.4 1.9 3.0 3 0 0 3 3 3 0 PHD/FYVE-zinc-finger like domain PHD_4 PF16866.5 EGD93008.1 - 2 8.5 21.0 0.27 11.4 4.8 3.0 2 0 0 2 2 2 0 PHD-finger DUF515 PF04415.12 EGD93008.1 - 3.6 5.9 4.2 11 4.3 4.2 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF515) C1_1 PF00130.22 EGD93008.1 - 6.3 6.8 24.9 0.5 10.3 4.5 3.4 3 0 0 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) GIY-YIG PF01541.24 EGD93010.1 - 6.9e-16 58.3 0.0 1.1e-15 57.7 0.0 1.3 1 0 0 1 1 1 1 GIY-YIG catalytic domain T5orf172 PF10544.9 EGD93010.1 - 0.12 12.9 0.1 0.21 12.1 0.1 1.7 1 1 0 1 1 1 0 T5orf172 domain Thymidylate_kin PF02223.17 EGD93011.1 - 8.5e-42 142.9 0.0 9.9e-42 142.7 0.0 1.0 1 0 0 1 1 1 1 Thymidylate kinase AAA_28 PF13521.6 EGD93011.1 - 0.00044 20.5 0.0 0.00052 20.3 0.0 1.1 1 0 0 1 1 1 1 AAA domain KTI12 PF08433.10 EGD93011.1 - 0.002 17.6 0.0 0.0041 16.6 0.0 1.4 1 1 0 1 1 1 1 Chromatin associated protein KTI12 AAA_22 PF13401.6 EGD93011.1 - 0.12 12.7 0.0 0.16 12.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain TGT PF01702.18 EGD93012.1 - 2.9e-62 210.8 0.0 3.6e-62 210.5 0.0 1.0 1 0 0 1 1 1 1 Queuine tRNA-ribosyltransferase MFS_1 PF07690.16 EGD93013.1 - 3.8e-32 111.6 28.8 3.8e-32 111.6 28.8 1.6 1 1 1 2 2 2 1 Major Facilitator Superfamily MTHFR PF02219.17 EGD93014.1 - 1.2e-92 310.3 0.0 2.2e-92 309.4 0.0 1.4 1 0 0 1 1 1 1 Methylenetetrahydrofolate reductase FLILHELTA PF10306.9 EGD93015.1 - 1.3e-29 102.4 0.0 2.2e-29 101.7 0.0 1.3 1 0 0 1 1 1 1 Hypothetical protein FLILHELTA DUF1279 PF06916.13 EGD93015.1 - 0.0043 17.6 0.4 0.0052 17.3 0.4 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF1279) NDK PF00334.19 EGD93016.1 - 4.5e-55 185.4 0.0 5.1e-55 185.2 0.0 1.0 1 0 0 1 1 1 1 Nucleoside diphosphate kinase Glyco_hydro_31 PF01055.26 EGD93017.1 - 2.9e-137 458.5 6.2 5.2e-137 457.6 6.2 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.6 EGD93017.1 - 1.3e-26 92.7 0.5 1.2e-25 89.6 0.2 2.4 2 0 0 2 2 2 1 Galactose mutarotase-like DUF5110 PF17137.4 EGD93017.1 - 5.1e-08 33.1 0.3 1.9e-07 31.3 0.3 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF5110) PQ-loop PF04193.14 EGD93018.1 - 1.2e-20 73.1 4.2 5.1e-13 48.6 0.3 2.6 2 0 0 2 2 2 2 PQ loop repeat ER_lumen_recept PF00810.18 EGD93018.1 - 0.0011 19.8 2.9 0.0043 17.9 2.9 1.9 1 1 0 1 1 1 1 ER lumen protein retaining receptor Phage_holin_5_2 PF16079.5 EGD93018.1 - 0.053 13.8 1.4 0.6 10.5 0.0 2.3 2 0 0 2 2 2 0 Phage holin family Hol44, in holin superfamily V NMT1 PF09084.11 EGD93020.1 - 0.00073 19.5 0.0 0.014 15.4 0.0 2.3 1 1 1 2 2 2 1 NMT1/THI5 like NMT1_3 PF16868.5 EGD93020.1 - 0.0058 16.1 0.0 0.0086 15.5 0.0 1.2 1 0 0 1 1 1 1 NMT1-like family NMT1_2 PF13379.6 EGD93020.1 - 0.0072 16.1 0.0 0.012 15.3 0.0 1.3 1 0 0 1 1 1 1 NMT1-like family SBP_bac_3 PF00497.20 EGD93020.1 - 0.03 13.8 0.0 0.21 11.0 0.0 2.0 1 1 0 1 1 1 0 Bacterial extracellular solute-binding proteins, family 3 FAD_binding_3 PF01494.19 EGD93021.1 - 5.4e-64 216.6 0.0 9e-63 212.6 0.0 2.0 1 1 0 1 1 1 1 FAD binding domain Phe_hydrox_dim PF07976.12 EGD93021.1 - 9.5e-24 84.3 0.0 2.7e-23 82.8 0.0 1.8 1 0 0 1 1 1 1 Phenol hydroxylase, C-terminal dimerisation domain Pyr_redox_2 PF07992.14 EGD93021.1 - 0.059 12.6 0.0 0.1 11.8 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Glyco_hydro_16 PF00722.21 EGD93022.1 - 4.3e-06 26.3 0.1 1e-05 25.1 0.0 1.6 2 0 0 2 2 2 1 Glycosyl hydrolases family 16 Ribosomal_L1 PF00687.21 EGD93023.1 - 8.1e-34 117.2 0.0 1.3e-33 116.5 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family COG2 PF06148.11 EGD93024.1 - 4.7e-30 104.4 1.1 9.2e-30 103.4 1.1 1.5 1 0 0 1 1 1 1 COG (conserved oligomeric Golgi) complex component, COG2 Vps51 PF08700.11 EGD93024.1 - 1.1e-05 25.5 1.7 2.4e-05 24.3 0.2 2.3 1 1 1 2 2 2 1 Vps51/Vps67 Sec8_exocyst PF04048.14 EGD93024.1 - 0.021 14.7 0.4 0.042 13.7 0.4 1.5 1 0 0 1 1 1 0 Sec8 exocyst complex component specific domain KxDL PF10241.9 EGD93024.1 - 0.031 14.6 0.7 0.11 12.8 0.7 2.0 1 0 0 1 1 1 0 Uncharacterized conserved protein Vps54_N PF10475.9 EGD93024.1 - 0.033 13.5 0.2 0.069 12.4 0.1 1.6 2 0 0 2 2 2 0 Vacuolar-sorting protein 54, of GARP complex COG5 PF10392.9 EGD93024.1 - 0.046 13.9 1.3 0.06 13.5 0.3 1.7 2 0 0 2 2 2 0 Golgi transport complex subunit 5 BLOC1S3 PF15753.5 EGD93024.1 - 0.049 13.8 1.2 1.7 8.7 0.0 2.4 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex 1 subunit 3 Spc7 PF08317.11 EGD93024.1 - 0.055 12.3 3.4 0.085 11.7 3.4 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein Atg14 PF10186.9 EGD93024.1 - 0.069 12.2 1.3 0.12 11.4 1.3 1.4 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Dor1 PF04124.12 EGD93024.1 - 0.086 11.5 1.4 0.12 11.0 1.4 1.2 1 0 0 1 1 1 0 Dor1-like family IFT20 PF14931.6 EGD93024.1 - 0.098 12.8 1.7 0.3 11.3 1.7 1.8 1 1 0 1 1 1 0 Intraflagellar transport complex B, subunit 20 DUF1690 PF07956.11 EGD93024.1 - 0.18 12.2 2.2 0.48 10.9 2.2 1.7 1 0 0 1 1 1 0 Protein of Unknown function (DUF1690) FTCD_C PF04961.12 EGD93024.1 - 0.19 11.4 0.3 0.77 9.5 0.0 1.9 1 1 1 2 2 2 0 Formiminotransferase-cyclodeaminase Bul1_C PF04426.12 EGD93024.1 - 0.21 11.0 0.9 7.4 5.9 0.0 2.1 1 1 1 2 2 2 0 Bul1 C terminus UPF0242 PF06785.11 EGD93024.1 - 0.42 10.7 4.7 0.58 10.2 3.3 1.9 2 1 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Sds3 PF08598.11 EGD93024.1 - 0.56 10.2 4.8 1.3 9.0 4.8 1.7 1 1 0 1 1 1 0 Sds3-like Seryl_tRNA_N PF02403.22 EGD93024.1 - 1.3 9.3 5.3 3 8.1 0.4 2.6 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain ParA PF10609.9 EGD93028.1 - 9.8e-86 287.2 0.0 1.3e-59 201.6 0.0 2.1 1 1 1 2 2 2 2 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 EGD93028.1 - 1.5e-09 38.0 0.0 3.5e-09 36.8 0.0 1.7 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain MipZ PF09140.11 EGD93028.1 - 5e-05 22.7 0.0 0.00012 21.5 0.0 1.5 2 0 0 2 2 2 1 ATPase MipZ AAA_31 PF13614.6 EGD93028.1 - 0.00013 22.0 0.3 0.00046 20.1 0.2 1.8 2 0 0 2 2 2 1 AAA domain ArsA_ATPase PF02374.15 EGD93028.1 - 0.00047 19.4 0.3 0.00098 18.4 0.3 1.4 1 0 0 1 1 1 1 Anion-transporting ATPase AAA_25 PF13481.6 EGD93028.1 - 0.00074 19.2 0.1 0.0014 18.3 0.1 1.4 1 0 0 1 1 1 1 AAA domain AAA_26 PF13500.6 EGD93028.1 - 0.011 15.5 0.8 1.4 8.7 0.0 2.3 2 0 0 2 2 2 0 AAA domain CBP_BcsQ PF06564.12 EGD93028.1 - 0.031 13.8 0.4 0.089 12.3 0.2 1.8 2 0 0 2 2 2 0 Cellulose biosynthesis protein BcsQ MeaB PF03308.16 EGD93028.1 - 0.047 12.7 0.2 0.077 12.0 0.2 1.3 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB OrfB_Zn_ribbon PF07282.11 EGD93028.1 - 0.074 13.0 0.2 0.17 11.9 0.2 1.5 1 0 0 1 1 1 0 Putative transposase DNA-binding domain CLP1_P PF16575.5 EGD93028.1 - 0.081 12.7 0.1 0.15 11.9 0.1 1.4 1 0 0 1 1 1 0 mRNA cleavage and polyadenylation factor CLP1 P-loop APS_kinase PF01583.20 EGD93028.1 - 0.09 12.7 0.1 0.14 12.0 0.1 1.3 1 0 0 1 1 1 0 Adenylylsulphate kinase SEP PF08059.13 EGD93029.1 - 1.3e-22 80.2 0.1 2.8e-22 79.1 0.1 1.6 1 0 0 1 1 1 1 SEP domain UBX PF00789.20 EGD93029.1 - 5.7e-14 52.1 0.0 8.8e-14 51.5 0.0 1.3 1 0 0 1 1 1 1 UBX domain UBA_4 PF14555.6 EGD93029.1 - 7.6e-14 51.3 0.0 1.3e-13 50.6 0.0 1.4 1 0 0 1 1 1 1 UBA-like domain TAP_C PF03943.13 EGD93029.1 - 0.0015 18.2 0.0 0.0026 17.4 0.0 1.4 1 0 0 1 1 1 1 TAP C-terminal domain TOM13 PF08219.11 EGD93030.1 - 9e-34 115.3 0.0 1.2e-33 115.0 0.0 1.1 1 0 0 1 1 1 1 Outer membrane protein TOM13 60KD_IMP PF02096.20 EGD93031.1 - 3.4e-20 72.6 0.1 5.7e-20 71.9 0.1 1.3 1 0 0 1 1 1 1 60Kd inner membrane protein DUF5326 PF17260.2 EGD93031.1 - 0.076 13.2 0.5 0.16 12.1 0.5 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5326) TAFII28 PF04719.14 EGD93032.1 - 7.6e-29 99.7 1.1 2.7e-26 91.5 0.4 2.6 2 1 0 2 2 2 2 hTAFII28-like protein conserved region SRP-alpha_N PF04086.13 EGD93032.1 - 0.65 9.9 13.8 0.32 10.9 3.2 2.1 2 0 0 2 2 2 0 Signal recognition particle, alpha subunit, N-terminal SAM_decarbox PF01536.16 EGD93033.1 - 1.3e-130 435.5 0.0 1.5e-130 435.3 0.0 1.0 1 0 0 1 1 1 1 Adenosylmethionine decarboxylase DUF5471 PF17565.2 EGD93034.1 - 0.16 12.3 1.9 0.2 12.0 0.6 1.8 1 1 1 2 2 2 0 Family of unknown function (DUF5471) TAF6_C PF07571.13 EGD93035.1 - 1.4e-30 105.5 0.0 3.1e-30 104.3 0.0 1.6 1 0 0 1 1 1 1 TAF6 C-terminal HEAT repeat domain TAF PF02969.17 EGD93035.1 - 4.1e-25 87.7 0.0 2.1e-24 85.5 0.0 2.2 3 0 0 3 3 3 1 TATA box binding protein associated factor (TAF) TFIID-31kDa PF02291.15 EGD93035.1 - 0.0015 18.6 0.1 0.0044 17.1 0.1 1.7 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Histone PF00125.24 EGD93035.1 - 0.0085 16.4 0.0 0.023 15.0 0.0 1.7 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 Bromo_TP PF07524.13 EGD93035.1 - 0.0098 15.9 0.0 0.024 14.7 0.0 1.6 1 0 0 1 1 1 1 Bromodomain associated CBFD_NFYB_HMF PF00808.23 EGD93035.1 - 0.059 13.7 0.0 0.21 11.9 0.0 2.0 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TAF4 PF05236.14 EGD93035.1 - 0.12 12.1 0.1 0.2 11.4 0.1 1.2 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family CRAL_TRIO PF00650.20 EGD93036.1 - 1.6e-12 47.4 0.0 2.5e-12 46.8 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 EGD93036.1 - 3.8e-09 36.6 0.0 1.1e-08 35.2 0.0 1.8 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain DDHD PF02862.17 EGD93036.1 - 8.7 6.4 6.8 13 5.8 0.2 2.2 2 0 0 2 2 2 0 DDHD domain IPP-2 PF04979.14 EGD93037.1 - 6.1e-20 72.3 15.6 6.1e-20 72.3 15.6 2.4 2 1 0 2 2 2 1 Protein phosphatase inhibitor 2 (IPP-2) Swm2 PF17083.5 EGD93038.1 - 0.046 13.7 0.1 0.1 12.6 0.1 1.5 1 0 0 1 1 1 0 Nucleolar protein Swm2 CAF1A PF12253.8 EGD93039.1 - 6.6e-22 77.5 4.4 6.6e-22 77.5 4.4 3.7 2 1 0 2 2 1 1 Chromatin assembly factor 1 subunit A Caldesmon PF02029.15 EGD93039.1 - 1.1e-06 27.8 28.0 2e-06 26.9 28.0 1.4 1 0 0 1 1 1 1 Caldesmon CAF-1_p150 PF11600.8 EGD93039.1 - 0.00026 20.7 59.5 0.00047 19.9 59.5 1.3 1 0 0 1 1 1 1 Chromatin assembly factor 1 complex p150 subunit, N-terminal RR_TM4-6 PF06459.12 EGD93039.1 - 0.011 15.6 29.4 0.03 14.2 29.4 1.8 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 SprA-related PF12118.8 EGD93039.1 - 0.019 14.1 22.6 0.031 13.4 22.6 1.3 1 0 0 1 1 1 0 SprA-related family Mem_trans PF03547.18 EGD93039.1 - 0.19 10.1 1.6 0.27 9.6 1.6 1.2 1 0 0 1 1 1 0 Membrane transport protein Asp-B-Hydro_N PF05279.11 EGD93039.1 - 0.31 11.1 32.5 0.6 10.1 32.5 1.4 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region DUF966 PF06136.13 EGD93039.1 - 2.3 7.9 23.9 4.2 7.0 23.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF966) Peptidase_S64 PF08192.11 EGD93039.1 - 3.3 6.1 18.6 4.9 5.5 18.6 1.2 1 0 0 1 1 1 0 Peptidase family S64 DUF262 PF03235.14 EGD93039.1 - 5.4 7.1 12.6 11 6.1 12.6 1.6 1 0 0 1 1 1 0 Protein of unknown function DUF262 CNDH2_C PF16858.5 EGD93039.1 - 5.8 6.7 36.2 5.5 6.8 25.8 3.1 3 0 0 3 3 3 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term Mitofilin PF09731.9 EGD93039.1 - 7.2 5.3 37.3 11 4.7 37.3 1.2 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Methyltransf_23 PF13489.6 EGD93041.1 - 7.8e-16 58.3 0.0 3.1e-15 56.4 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EGD93041.1 - 0.00021 22.0 0.1 0.0061 17.2 0.0 2.3 1 1 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EGD93041.1 - 0.0042 17.7 0.0 0.0075 16.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EGD93041.1 - 0.0077 17.0 0.0 0.021 15.6 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EGD93041.1 - 0.054 13.3 0.0 0.3 10.9 0.0 1.9 2 0 0 2 2 2 0 Methyltransferase domain CoA_transf_3 PF02515.17 EGD93043.1 - 1.3e-68 231.9 0.0 1.5e-68 231.6 0.0 1.0 1 0 0 1 1 1 1 CoA-transferase family III DNA_ligase_OB_2 PF14743.6 EGD93043.1 - 0.16 12.1 0.0 0.37 10.8 0.0 1.7 1 0 0 1 1 1 0 DNA ligase OB-like domain Fez1 PF06818.15 EGD93044.1 - 0.0092 16.5 28.5 0.0092 16.5 28.5 4.2 2 2 2 4 4 4 2 Fez1 Macoilin PF09726.9 EGD93044.1 - 0.024 13.2 70.5 0.23 10.0 38.5 2.4 2 1 0 2 2 2 0 Macoilin family Baculo_PEP_C PF04513.12 EGD93044.1 - 0.35 10.9 22.0 0.22 11.5 3.5 4.1 2 2 4 6 6 6 0 Baculovirus polyhedron envelope protein, PEP, C terminus adh_short_C2 PF13561.6 EGD93045.1 - 6.5e-57 192.8 0.0 8e-57 192.5 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EGD93045.1 - 1.3e-46 158.6 0.0 1.9e-46 158.0 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EGD93045.1 - 1.4e-11 44.6 0.5 2.3e-11 44.0 0.5 1.3 1 0 0 1 1 1 1 KR domain 3Beta_HSD PF01073.19 EGD93045.1 - 0.01 14.9 0.1 0.014 14.4 0.1 1.3 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family HATPase_c PF02518.26 EGD93045.1 - 0.047 14.2 0.0 0.1 13.1 0.0 1.6 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Epimerase PF01370.21 EGD93045.1 - 0.05 13.1 0.1 0.11 12.0 0.1 1.7 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family CcmE PF03100.15 EGD93045.1 - 0.062 13.3 0.0 0.11 12.4 0.0 1.5 1 0 0 1 1 1 0 CcmE YjeF_N PF03853.15 EGD93045.1 - 0.077 12.9 0.0 0.44 10.4 0.0 2.0 1 1 0 2 2 2 0 YjeF-related protein N-terminus GDP_Man_Dehyd PF16363.5 EGD93045.1 - 0.12 11.7 0.1 0.16 11.3 0.1 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Peptidase_S64 PF08192.11 EGD93046.1 - 0.00073 18.2 0.0 0.0029 16.2 0.0 1.8 1 1 0 1 1 1 1 Peptidase family S64 Glyco_hydro_18 PF00704.28 EGD93048.1 - 8.3e-16 58.6 0.0 9.7e-16 58.4 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 PhoD PF09423.10 EGD93049.1 - 1.2e-37 129.8 0.0 3.7e-37 128.2 0.0 1.8 1 1 0 1 1 1 1 PhoD-like phosphatase Pur_ac_phosph_N PF16656.5 EGD93049.1 - 0.056 14.0 1.0 0.27 11.8 1.0 2.2 1 1 0 1 1 1 0 Purple acid Phosphatase, N-terminal domain SRP54 PF00448.22 EGD93050.1 - 3.1e-74 248.9 1.9 6.1e-74 247.9 1.9 1.5 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain SRP_SPB PF02978.19 EGD93050.1 - 2.6e-28 98.5 0.1 2.6e-28 98.5 0.1 4.3 2 2 3 5 5 4 1 Signal peptide binding domain SRP54_N PF02881.19 EGD93050.1 - 6.5e-20 71.1 0.4 1.6e-19 69.9 0.4 1.7 1 0 0 1 1 1 1 SRP54-type protein, helical bundle domain cobW PF02492.19 EGD93050.1 - 4.9e-07 29.5 0.7 1.9e-06 27.6 0.6 2.1 2 1 0 2 2 1 1 CobW/HypB/UreG, nucleotide-binding domain AAA_33 PF13671.6 EGD93050.1 - 2.9e-06 27.5 0.1 8.1e-06 26.1 0.1 1.8 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 EGD93050.1 - 7.2e-05 22.2 0.1 0.00014 21.2 0.1 1.4 1 0 0 1 1 1 1 Zeta toxin AAA_17 PF13207.6 EGD93050.1 - 7.3e-05 23.2 0.1 7.3e-05 23.2 0.1 2.3 3 0 0 3 3 1 1 AAA domain MeaB PF03308.16 EGD93050.1 - 0.00035 19.7 0.8 0.0033 16.5 0.0 2.6 3 0 0 3 3 3 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_16 PF13191.6 EGD93050.1 - 0.00054 20.4 0.0 0.0017 18.7 0.0 1.8 1 1 0 1 1 1 1 AAA ATPase domain ATP_bind_1 PF03029.17 EGD93050.1 - 0.00065 19.6 0.8 0.024 14.4 0.1 2.5 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein ResIII PF04851.15 EGD93050.1 - 0.0018 18.3 0.9 0.0074 16.3 0.9 2.0 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit 6PF2K PF01591.18 EGD93050.1 - 0.0019 17.5 0.0 0.0037 16.6 0.0 1.4 1 0 0 1 1 1 1 6-phosphofructo-2-kinase APS_kinase PF01583.20 EGD93050.1 - 0.0024 17.8 0.1 0.0052 16.7 0.1 1.5 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_30 PF13604.6 EGD93050.1 - 0.0044 16.8 2.3 0.0049 16.6 0.3 2.1 2 1 0 2 2 2 1 AAA domain SRPRB PF09439.10 EGD93050.1 - 0.0048 16.3 2.4 2.1 7.7 1.9 3.0 2 1 0 2 2 2 1 Signal recognition particle receptor beta subunit CbiA PF01656.23 EGD93050.1 - 0.0075 16.3 0.0 0.014 15.5 0.0 1.8 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain Thymidylate_kin PF02223.17 EGD93050.1 - 0.0097 15.6 0.2 0.038 13.7 0.2 2.0 1 0 0 1 1 1 1 Thymidylate kinase AAA_22 PF13401.6 EGD93050.1 - 0.011 16.1 0.0 0.046 14.0 0.0 2.2 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 EGD93050.1 - 0.015 15.8 0.1 0.042 14.4 0.0 1.8 2 0 0 2 2 1 0 AAA domain Methyltransf_25 PF13649.6 EGD93050.1 - 0.02 15.6 0.5 1.7 9.4 0.0 3.1 3 0 0 3 3 3 0 Methyltransferase domain MMR_HSR1 PF01926.23 EGD93050.1 - 0.021 14.9 0.2 0.094 12.8 0.2 2.1 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_24 PF13479.6 EGD93050.1 - 0.037 13.7 0.1 0.095 12.4 0.1 1.7 1 0 0 1 1 1 0 AAA domain Arf PF00025.21 EGD93050.1 - 0.042 13.3 0.0 0.11 12.0 0.0 1.7 1 0 0 1 1 1 0 ADP-ribosylation factor family AAA_28 PF13521.6 EGD93050.1 - 0.043 14.1 0.0 0.079 13.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.6 EGD93050.1 - 0.044 14.1 0.2 0.11 12.8 0.2 1.7 1 0 0 1 1 1 0 AAA domain MobB PF03205.14 EGD93050.1 - 0.054 13.4 0.1 0.15 11.9 0.1 1.8 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_31 PF13614.6 EGD93050.1 - 0.076 12.9 0.7 0.61 10.0 0.2 2.3 1 1 1 2 2 2 0 AAA domain VirE PF05272.11 EGD93050.1 - 0.1 12.3 0.1 0.25 11.1 0.1 1.6 1 0 0 1 1 1 0 Virulence-associated protein E ABC_tran PF00005.27 EGD93050.1 - 0.13 12.8 1.0 0.32 11.5 0.1 2.2 2 1 0 2 2 2 0 ABC transporter Rrp15p PF07890.12 EGD93051.1 - 1.2e-38 132.5 8.3 1.2e-38 132.5 8.3 2.0 2 0 0 2 2 2 1 Rrp15p RRN3 PF05327.11 EGD93051.1 - 0.57 8.7 4.7 0.79 8.2 4.7 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 FliL PF03748.14 EGD93051.1 - 1.8 9.2 6.0 13 6.4 0.0 3.1 2 1 1 3 3 3 0 Flagellar basal body-associated protein FliL Ndc1_Nup PF09531.10 EGD93051.1 - 3.5 6.2 6.2 4.5 5.9 6.2 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Fer2 PF00111.27 EGD93052.1 - 3.4e-14 52.6 0.6 5e-14 52.0 0.6 1.3 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Mito_carr PF00153.27 EGD93053.1 - 8e-10 38.5 0.8 0.0098 15.8 0.0 4.7 4 1 0 4 4 4 4 Mitochondrial carrier protein bZIP_1 PF00170.21 EGD93054.1 - 4e-08 33.2 11.3 1.1e-07 31.9 11.3 1.7 1 0 0 1 1 1 1 bZIP transcription factor Hap4_Hap_bind PF10297.9 EGD93054.1 - 1e-07 31.8 6.9 2.3e-07 30.7 6.9 1.7 1 0 0 1 1 1 1 Minimal binding motif of Hap4 for binding to Hap2/3/5 Fmp27_WPPW PF10359.9 EGD93054.1 - 0.021 13.7 2.9 0.028 13.3 2.9 1.2 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain DUF812 PF05667.11 EGD93054.1 - 0.024 13.6 7.2 0.035 13.0 7.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF812) dsrm PF00035.26 EGD93054.1 - 0.074 13.8 0.0 0.19 12.4 0.0 1.7 1 0 0 1 1 1 0 Double-stranded RNA binding motif PSI_PsaF PF02507.15 EGD93054.1 - 0.19 11.5 1.2 0.34 10.7 1.2 1.3 1 0 0 1 1 1 0 Photosystem I reaction centre subunit III bZIP_2 PF07716.15 EGD93054.1 - 0.25 11.5 17.3 1.2 9.3 16.9 2.3 1 1 1 2 2 2 0 Basic region leucine zipper SlyX PF04102.12 EGD93054.1 - 0.39 11.4 7.4 1.3 9.7 6.3 2.4 1 1 1 2 2 2 0 SlyX bZIP_Maf PF03131.17 EGD93054.1 - 0.71 10.4 11.5 2.5 8.7 11.5 1.9 1 0 0 1 1 1 0 bZIP Maf transcription factor Golgin_A5 PF09787.9 EGD93054.1 - 0.87 9.0 12.5 2.3 7.6 12.5 1.6 1 1 0 1 1 1 0 Golgin subfamily A member 5 DUF4407 PF14362.6 EGD93054.1 - 2.8 7.2 6.2 4.6 6.5 6.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) V_ATPase_I PF01496.19 EGD93054.1 - 3.7 5.4 5.9 4.6 5.0 5.9 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Methyltransf_24 PF13578.6 EGD93055.1 - 3.2e-12 47.4 0.0 4.7e-12 46.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_3 PF01596.17 EGD93055.1 - 0.0014 17.8 0.1 0.0063 15.7 0.1 1.8 1 1 0 1 1 1 1 O-methyltransferase TylF PF05711.11 EGD93055.1 - 0.14 11.4 0.0 0.2 10.9 0.0 1.2 1 0 0 1 1 1 0 Macrocin-O-methyltransferase (TylF) Ribosomal_L19 PF01245.20 EGD93056.1 - 2.2e-11 43.7 0.1 5.3e-11 42.4 0.1 1.6 1 0 0 1 1 1 1 Ribosomal protein L19 AMP-binding PF00501.28 EGD93058.1 - 1.2e-16 60.4 0.0 1.7e-07 30.2 0.0 2.2 2 0 0 2 2 2 2 AMP-binding enzyme NPCC PF08058.11 EGD93059.1 - 2.4e-24 85.8 0.0 3.7e-24 85.2 0.0 1.3 1 0 0 1 1 1 1 Nuclear pore complex component Glycogen_syn PF05693.13 EGD93060.1 - 0 1137.7 0.0 0 1137.4 0.0 1.0 1 0 0 1 1 1 1 Glycogen synthase Glyco_transf_4 PF13439.6 EGD93060.1 - 1.4e-05 25.1 0.2 3.6e-05 23.8 0.2 1.7 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glycos_transf_1 PF00534.20 EGD93060.1 - 2.2e-05 24.1 0.0 0.0064 16.1 0.0 2.3 2 0 0 2 2 2 2 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 EGD93060.1 - 2.7e-05 24.6 0.0 0.031 14.7 0.0 2.4 2 0 0 2 2 2 2 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 EGD93060.1 - 0.00016 22.2 0.1 0.00037 21.0 0.0 1.8 2 0 0 2 2 2 1 Glycosyl transferase 4-like domain Glyco_transf_5 PF08323.11 EGD93060.1 - 0.00016 21.4 0.1 0.00035 20.3 0.1 1.5 1 0 0 1 1 1 1 Starch synthase catalytic domain polyprenyl_synt PF00348.17 EGD93061.1 - 3.2e-68 229.6 0.0 7e-53 179.3 0.1 2.1 1 1 1 2 2 2 2 Polyprenyl synthetase Imm68 PF15583.6 EGD93061.1 - 0.068 13.3 0.0 18 5.5 0.0 2.3 2 0 0 2 2 2 0 Immunity protein 68 ANAPC8 PF04049.13 EGD93062.1 - 6.3e-53 178.6 0.0 1.4e-52 177.5 0.0 1.6 1 0 0 1 1 1 1 Anaphase promoting complex subunit 8 / Cdc23 TPR_1 PF00515.28 EGD93062.1 - 9.2e-25 85.4 9.0 0.00018 21.2 0.0 8.2 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_8 PF13181.6 EGD93062.1 - 9.1e-21 72.3 18.5 1.8e-05 24.6 0.0 9.2 9 0 0 9 9 9 4 Tetratricopeptide repeat TPR_2 PF07719.17 EGD93062.1 - 1.9e-20 71.3 23.6 0.061 13.5 2.8 9.2 9 1 0 9 9 9 6 Tetratricopeptide repeat TPR_14 PF13428.6 EGD93062.1 - 2.1e-11 43.6 21.7 0.007 17.1 0.0 8.8 7 2 2 9 9 9 3 Tetratricopeptide repeat TPR_11 PF13414.6 EGD93062.1 - 4.7e-11 42.2 4.0 1.1e-06 28.2 0.3 4.9 3 2 2 5 5 5 2 TPR repeat TPR_19 PF14559.6 EGD93062.1 - 9.7e-11 42.0 13.3 0.065 13.8 0.4 7.6 7 2 0 7 7 6 3 Tetratricopeptide repeat TPR_12 PF13424.6 EGD93062.1 - 1.1e-10 41.6 7.8 0.24 11.7 0.0 7.0 6 1 0 6 6 6 2 Tetratricopeptide repeat TPR_16 PF13432.6 EGD93062.1 - 4.7e-10 40.0 20.1 1.7e-05 25.4 0.0 7.1 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_9 PF13371.6 EGD93062.1 - 5.8e-10 39.2 13.5 0.00012 22.1 0.4 6.2 5 1 1 6 6 6 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EGD93062.1 - 2.8e-07 30.7 21.3 0.11 12.8 0.3 6.7 8 0 0 8 8 6 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.6 EGD93062.1 - 4.4e-06 26.7 9.4 1.3 9.5 0.0 7.1 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_7 PF13176.6 EGD93062.1 - 0.00026 20.8 9.8 1.9 8.7 0.1 6.0 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_6 PF13174.6 EGD93062.1 - 0.00072 20.0 27.0 0.72 10.6 0.2 9.0 9 1 0 9 9 9 1 Tetratricopeptide repeat TPR_15 PF13429.6 EGD93062.1 - 0.0035 16.6 9.9 0.0039 16.5 4.5 3.5 3 1 1 4 4 4 1 Tetratricopeptide repeat Sel1 PF08238.12 EGD93062.1 - 0.035 14.8 6.5 7 7.5 0.1 4.2 3 0 0 3 3 3 0 Sel1 repeat HrpB1_HrpK PF09613.10 EGD93062.1 - 0.053 13.2 0.0 0.16 11.6 0.0 1.8 1 0 0 1 1 1 0 Bacterial type III secretion protein (HrpB1_HrpK) TPR_3 PF07720.12 EGD93062.1 - 0.27 11.3 3.5 0.5 10.4 0.1 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat PPR PF01535.20 EGD93062.1 - 1.3 9.4 4.8 38 4.8 0.0 4.5 5 0 0 5 5 5 0 PPR repeat DNA_ligase_A_M PF01068.21 EGD93063.1 - 5.4e-23 81.7 0.0 8.8e-23 81.0 0.0 1.3 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 EGD93063.1 - 1.8e-19 70.7 0.0 3.3e-19 69.9 0.0 1.4 1 0 0 1 1 1 1 DNA ligase N terminus Inhibitor_I48 PF10467.9 EGD93064.1 - 0.12 12.2 0.0 0.16 11.8 0.0 1.1 1 0 0 1 1 1 0 Peptidase inhibitor clitocypin DUF3449 PF11931.8 EGD93065.1 - 2.2e-76 255.7 0.3 2.2e-76 255.7 0.3 2.0 3 0 0 3 3 3 1 Domain of unknown function (DUF3449) SF3A3 PF16837.5 EGD93065.1 - 4.7e-23 81.5 1.8 7.1e-23 80.9 0.6 1.9 2 0 0 2 2 2 1 Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 SF3a60_bindingd PF12108.8 EGD93065.1 - 2.1e-11 43.5 0.2 4.7e-11 42.4 0.2 1.7 1 0 0 1 1 1 1 Splicing factor SF3a60 binding domain zf-met PF12874.7 EGD93065.1 - 2.7e-09 37.1 3.9 1.2e-07 31.9 1.0 2.4 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EGD93065.1 - 7.4e-08 32.5 1.0 7.4e-08 32.5 1.0 2.7 2 1 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 EGD93065.1 - 0.00023 21.5 0.2 0.011 16.0 0.0 2.8 2 0 0 2 2 2 1 C2H2 type zinc-finger (2 copies) zf-LYAR PF08790.11 EGD93065.1 - 0.053 13.4 0.2 0.13 12.1 0.2 1.7 1 0 0 1 1 1 0 LYAR-type C2HC zinc finger zf-C2H2_4 PF13894.6 EGD93065.1 - 0.087 13.7 1.4 5.3 8.2 0.1 2.7 2 0 0 2 2 2 0 C2H2-type zinc finger PRP9_N PF16958.5 EGD93065.1 - 1.5 8.8 20.2 0.3 11.1 1.2 3.6 3 1 1 4 4 4 0 Pre-mRNA-splicing factor PRP9 N-terminus zf-C2H2 PF00096.26 EGD93065.1 - 2.8 8.6 4.3 5.6 7.6 0.5 2.6 2 0 0 2 2 2 0 Zinc finger, C2H2 type DEAD PF00270.29 EGD93066.1 - 1.3e-41 142.3 0.1 2.3e-41 141.5 0.1 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EGD93066.1 - 1.6e-33 115.4 0.1 6.5e-33 113.4 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain AAA_30 PF13604.6 EGD93066.1 - 0.00068 19.4 0.0 0.001 18.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain ResIII PF04851.15 EGD93066.1 - 0.00085 19.4 0.0 0.0014 18.6 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 EGD93066.1 - 0.0028 18.0 0.1 0.027 14.8 0.1 2.2 2 0 0 2 2 2 1 AAA domain Flavi_DEAD PF07652.14 EGD93066.1 - 0.037 14.0 0.3 0.14 12.1 0.1 2.2 1 1 1 2 2 2 0 Flavivirus DEAD domain Helicase_RecD PF05127.14 EGD93066.1 - 0.05 13.5 0.0 0.083 12.7 0.0 1.4 1 0 0 1 1 1 0 Helicase TniB PF05621.11 EGD93066.1 - 0.059 12.8 0.0 0.12 11.7 0.0 1.5 1 0 0 1 1 1 0 Bacterial TniB protein AAA_22 PF13401.6 EGD93066.1 - 0.22 11.8 1.0 1.2 9.4 1.0 2.1 1 1 0 1 1 1 0 AAA domain WD40 PF00400.32 EGD93067.1 - 5.4e-24 84.0 8.1 0.00015 22.4 0.0 7.9 8 0 0 8 8 8 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EGD93067.1 - 8.1e-14 51.7 1.2 0.0026 18.0 0.0 5.2 3 2 3 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EGD93067.1 - 0.00034 19.7 0.2 0.032 13.2 0.0 2.7 1 1 2 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 EGD93067.1 - 0.0018 18.1 2.0 20 5.3 0.0 5.1 5 0 0 5 5 5 1 WD40-like Beta Propeller Repeat eIF2A PF08662.11 EGD93067.1 - 0.0047 16.8 0.0 0.53 10.1 0.0 2.4 2 0 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A Cytochrom_D1 PF02239.16 EGD93067.1 - 0.16 10.4 0.0 1.2 7.6 0.0 2.0 2 0 0 2 2 2 0 Cytochrome D1 heme domain ATP-synt_ab PF00006.25 EGD93068.1 - 1.6e-109 364.6 0.0 2.2e-109 364.1 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_Xtn PF16886.5 EGD93068.1 - 2.4e-44 150.1 0.0 5.1e-44 149.0 0.0 1.6 1 0 0 1 1 1 1 ATPsynthase alpha/beta subunit N-term extension ATP-synt_ab_N PF02874.23 EGD93068.1 - 2.3e-14 53.7 3.6 4.8e-14 52.6 3.6 1.6 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain Menin PF05053.13 EGD93068.1 - 0.16 10.3 9.3 0.24 9.7 9.3 1.2 1 0 0 1 1 1 0 Menin Presenilin PF01080.17 EGD93068.1 - 0.95 8.2 3.4 1.4 7.6 3.4 1.2 1 0 0 1 1 1 0 Presenilin Dynamin_M PF01031.20 EGD93069.1 - 1.5e-101 339.4 0.0 2.9e-101 338.4 0.0 1.5 1 0 0 1 1 1 1 Dynamin central region Dynamin_N PF00350.23 EGD93069.1 - 5.2e-57 192.6 0.2 9.8e-57 191.7 0.2 1.5 1 0 0 1 1 1 1 Dynamin family GED PF02212.18 EGD93069.1 - 8.5e-30 102.8 2.8 2.2e-29 101.4 2.8 1.8 1 0 0 1 1 1 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.23 EGD93069.1 - 6.3e-06 26.2 1.1 3.7e-05 23.8 1.1 2.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase DUF2738 PF10927.8 EGD93069.1 - 0.065 12.3 0.0 0.13 11.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2738) AAA_16 PF13191.6 EGD93069.1 - 0.075 13.4 0.0 0.2 12.0 0.0 1.8 1 0 0 1 1 1 0 AAA ATPase domain AAA_15 PF13175.6 EGD93069.1 - 0.26 11.0 3.2 2.1 8.0 0.4 2.5 2 1 0 2 2 2 0 AAA ATPase domain COesterase PF00135.28 EGD93070.1 - 1.2e-77 261.9 0.0 9e-73 245.9 0.0 2.0 1 1 1 2 2 2 2 Carboxylesterase family Abhydrolase_3 PF07859.13 EGD93070.1 - 1.6e-14 54.2 0.0 3e-14 53.4 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EGD93070.1 - 0.00048 20.8 1.2 0.0012 19.6 1.1 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family DUF2974 PF11187.8 EGD93070.1 - 0.012 15.2 0.0 0.018 14.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) Abhydrolase_1 PF00561.20 EGD93070.1 - 0.05 13.2 0.0 0.071 12.7 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold PGAP1 PF07819.13 EGD93070.1 - 0.12 12.1 0.0 0.19 11.4 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein Abhydrolase_5 PF12695.7 EGD93070.1 - 0.14 11.9 0.0 0.28 10.9 0.0 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase family TrkH PF02386.16 EGD93071.1 - 2.2e-145 485.0 2.0 5.4e-143 477.1 2.2 2.1 2 0 0 2 2 2 2 Cation transport protein KASH_CCD PF14662.6 EGD93074.1 - 0.0064 16.3 4.4 0.0076 16.1 3.3 1.6 2 0 0 2 2 2 1 Coiled-coil region of CCDC155 or KASH PH PF00169.29 EGD93077.1 - 3.3e-05 24.3 0.3 8.6e-05 23.0 0.3 1.6 1 0 0 1 1 1 1 PH domain NOA36 PF06524.12 EGD93077.1 - 0.11 11.8 5.8 0.24 10.7 5.8 1.5 1 0 0 1 1 1 0 NOA36 protein CDC45 PF02724.14 EGD93077.1 - 5.6 5.1 6.1 9.5 4.4 6.1 1.3 1 0 0 1 1 1 0 CDC45-like protein Cwf_Cwc_15 PF04889.12 EGD93077.1 - 7.4 6.2 10.0 0.99 9.1 4.4 2.3 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein F-box-like PF12937.7 EGD93078.1 - 6.6e-08 32.3 0.0 1.4e-07 31.3 0.0 1.6 1 0 0 1 1 1 1 F-box-like LRR_4 PF12799.7 EGD93078.1 - 0.0013 19.0 2.4 40 4.8 0.1 4.8 4 1 1 5 5 5 3 Leucine Rich repeats (2 copies) F-box PF00646.33 EGD93078.1 - 0.044 13.7 0.2 4.3 7.3 0.0 3.3 3 0 0 3 3 3 0 F-box domain DUF1688 PF07958.11 EGD93079.1 - 1.3e-183 610.6 0.0 1.5e-183 610.3 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1688) TPR_2 PF07719.17 EGD93081.1 - 5.4e-06 26.1 0.6 0.57 10.4 0.3 3.9 4 0 0 4 4 4 2 Tetratricopeptide repeat UBA PF00627.31 EGD93081.1 - 0.00049 20.0 0.0 0.0013 18.5 0.0 1.8 1 0 0 1 1 1 1 UBA/TS-N domain TPR_1 PF00515.28 EGD93081.1 - 0.003 17.3 0.0 3.6 7.6 0.1 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 EGD93081.1 - 0.022 15.0 0.0 0.44 10.9 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat DnaJ PF00226.31 EGD93081.1 - 0.052 13.7 0.0 0.12 12.5 0.0 1.6 1 0 0 1 1 1 0 DnaJ domain Ank_5 PF13857.6 EGD93082.1 - 1.1e-17 63.8 3.9 3.8e-09 36.6 0.1 3.3 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 EGD93082.1 - 2.9e-13 50.2 0.2 9.8e-13 48.5 0.1 2.0 2 1 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EGD93082.1 - 3.5e-11 43.4 0.0 8e-06 26.3 0.0 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EGD93082.1 - 1.2e-07 31.4 0.4 0.031 14.8 0.0 3.6 3 0 0 3 3 3 2 Ankyrin repeat Ank PF00023.30 EGD93082.1 - 5.5e-07 29.7 0.9 0.059 13.8 0.1 3.5 3 1 0 3 3 3 2 Ankyrin repeat bZIP_1 PF00170.21 EGD93082.1 - 0.075 13.1 7.0 0.16 12.1 7.0 1.5 1 0 0 1 1 1 0 bZIP transcription factor AMP-binding PF00501.28 EGD93083.1 - 1.6e-73 247.7 0.0 2.3e-73 247.2 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme Condensation PF00668.20 EGD93083.1 - 4.6e-32 111.3 0.0 1e-28 100.2 0.0 2.1 2 0 0 2 2 2 2 Condensation domain PP-binding PF00550.25 EGD93083.1 - 2.5e-10 40.5 0.0 7.2e-09 35.9 0.0 2.8 2 0 0 2 2 2 1 Phosphopantetheine attachment site DegT_DnrJ_EryC1 PF01041.17 EGD93084.1 - 7.1e-60 203.2 0.0 1.1e-59 202.6 0.0 1.3 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family GFO_IDH_MocA PF01408.22 EGD93084.1 - 5.9e-19 69.1 0.0 1.5e-18 67.7 0.0 1.7 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold Beta_elim_lyase PF01212.21 EGD93084.1 - 0.00044 19.6 0.0 0.00079 18.8 0.0 1.4 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_5 PF00266.19 EGD93084.1 - 0.00053 19.0 0.0 0.001 18.1 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class-V CoA_binding PF02629.19 EGD93084.1 - 0.00097 19.8 0.0 0.0034 18.0 0.0 1.9 2 0 0 2 2 2 1 CoA binding domain Cys_Met_Meta_PP PF01053.20 EGD93084.1 - 0.0022 16.6 0.0 0.0035 15.9 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Semialdhyde_dh PF01118.24 EGD93084.1 - 0.0056 17.1 0.0 0.012 16.1 0.0 1.5 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain 5_nucleotid_C PF02872.18 EGD93086.1 - 3.8e-36 124.7 0.0 7.6e-36 123.7 0.0 1.5 1 0 0 1 1 1 1 5'-nucleotidase, C-terminal domain Metallophos PF00149.28 EGD93086.1 - 0.00038 21.0 0.0 0.00079 20.0 0.0 1.6 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase tRNA-synt_1e PF01406.19 EGD93087.1 - 1.3e-114 382.6 0.0 2e-114 382.0 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.11 EGD93087.1 - 2.6e-05 23.2 0.4 0.09 11.5 0.2 2.4 2 0 0 2 2 2 2 tRNA synthetases class I (M) DALR_2 PF09190.11 EGD93087.1 - 0.00061 20.2 0.1 0.0019 18.7 0.1 1.9 1 0 0 1 1 1 1 DALR domain tRNA-synt_1f PF01921.18 EGD93087.1 - 0.048 12.6 0.0 0.92 8.4 0.0 2.3 2 0 0 2 2 2 0 tRNA synthetases class I (K) GCD14 PF08704.10 EGD93088.1 - 1.7e-62 211.3 0.0 1.8e-61 208.0 0.0 2.1 1 1 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit ABC_membrane PF00664.23 EGD93089.1 - 3.5e-85 286.0 38.8 5.2e-45 154.2 14.6 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EGD93089.1 - 4.1e-69 231.4 0.0 6.7e-34 117.4 0.0 2.5 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EGD93089.1 - 4.4e-12 45.9 7.7 0.0014 18.1 0.1 4.2 3 1 0 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EGD93089.1 - 7e-08 32.1 1.0 0.012 15.3 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 EGD93089.1 - 2.4e-07 31.3 0.5 0.0038 17.6 0.1 3.1 2 2 0 2 2 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 EGD93089.1 - 2.4e-06 27.5 0.2 0.047 13.6 0.0 3.0 3 0 0 3 3 2 2 RsgA GTPase AAA_15 PF13175.6 EGD93089.1 - 3.1e-06 27.1 0.0 0.052 13.2 0.0 2.4 2 0 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.6 EGD93089.1 - 3.2e-06 27.5 0.6 0.022 15.1 0.0 3.9 2 2 0 2 2 2 1 AAA domain AAA_23 PF13476.6 EGD93089.1 - 4.3e-06 27.4 0.3 0.042 14.3 0.0 2.5 2 0 0 2 2 2 2 AAA domain DEAD PF00270.29 EGD93089.1 - 9.1e-06 25.5 0.0 0.0055 16.5 0.0 2.9 2 1 0 2 2 2 1 DEAD/DEAH box helicase ABC_ATPase PF09818.9 EGD93089.1 - 1.4e-05 24.1 2.0 0.011 14.5 0.1 2.6 3 0 0 3 3 3 2 Predicted ATPase of the ABC class SbcCD_C PF13558.6 EGD93089.1 - 0.00011 22.4 2.0 0.25 11.6 0.2 3.5 2 2 0 2 2 2 2 Putative exonuclease SbcCD, C subunit MMR_HSR1 PF01926.23 EGD93089.1 - 0.00027 21.0 0.0 1.4 9.1 0.0 3.0 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_21 PF13304.6 EGD93089.1 - 0.00047 20.1 0.1 0.23 11.2 0.0 2.8 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system DUF87 PF01935.17 EGD93089.1 - 0.0014 18.7 0.5 1.4 8.9 0.0 2.7 3 0 0 3 3 2 2 Helicase HerA, central domain Zeta_toxin PF06414.12 EGD93089.1 - 0.0063 15.8 0.0 1.3 8.3 0.0 2.4 2 0 0 2 2 2 1 Zeta toxin AAA_30 PF13604.6 EGD93089.1 - 0.0078 15.9 0.4 6.7 6.4 0.0 3.7 3 1 0 3 3 3 0 AAA domain FtsK_SpoIIIE PF01580.18 EGD93089.1 - 0.013 14.9 0.2 0.42 9.9 0.0 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_7 PF12775.7 EGD93089.1 - 0.017 14.6 0.0 1.4 8.4 0.0 2.5 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_33 PF13671.6 EGD93089.1 - 0.023 14.9 0.0 12 6.1 0.0 2.7 2 0 0 2 2 2 0 AAA domain G-alpha PF00503.20 EGD93089.1 - 0.027 13.6 0.0 0.61 9.2 0.0 2.2 2 0 0 2 2 2 0 G-protein alpha subunit AAA_5 PF07728.14 EGD93089.1 - 0.066 13.2 0.0 49 3.9 0.0 3.9 5 0 0 5 5 4 0 AAA domain (dynein-related subfamily) AAA_10 PF12846.7 EGD93089.1 - 0.073 12.0 0.0 12 4.7 0.0 2.5 2 0 0 2 2 2 0 AAA-like domain TMEM100 PF16311.5 EGD93089.1 - 0.085 12.4 0.2 0.24 11.0 0.2 1.7 1 0 0 1 1 1 0 Transmembrane protein 100 AAA_25 PF13481.6 EGD93089.1 - 0.1 12.1 0.1 27 4.2 0.0 3.2 3 0 0 3 3 3 0 AAA domain AAA_18 PF13238.6 EGD93089.1 - 0.13 12.8 0.0 23 5.6 0.0 2.6 2 0 0 2 2 2 0 AAA domain ATP-synt_ab PF00006.25 EGD93089.1 - 1.2 8.7 3.2 29 4.2 1.0 3.2 3 1 0 3 3 2 0 ATP synthase alpha/beta family, nucleotide-binding domain Dynamin_N PF00350.23 EGD93089.1 - 4.1 7.4 6.8 24 4.9 0.2 3.7 5 0 0 5 5 3 0 Dynamin family adh_short PF00106.25 EGD93090.1 - 1e-40 139.3 0.0 1.4e-40 138.9 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EGD93090.1 - 9e-27 94.1 0.0 1.2e-26 93.8 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase DUF1776 PF08643.10 EGD93090.1 - 5.5e-07 29.3 0.0 7.1e-07 28.9 0.0 1.1 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) KR PF08659.10 EGD93090.1 - 2.9e-06 27.3 0.0 7e-06 26.1 0.0 1.5 2 0 0 2 2 2 1 KR domain PQ-loop PF04193.14 EGD93091.1 - 3.4e-40 135.6 10.2 2.2e-20 72.2 1.0 2.7 2 0 0 2 2 2 2 PQ loop repeat NMN_transporter PF04973.12 EGD93091.1 - 4.1 7.3 11.2 0.23 11.4 2.9 2.7 2 1 0 2 2 2 0 Nicotinamide mononucleotide transporter SGS PF05002.15 EGD93092.1 - 1e-27 96.0 9.0 6.4e-27 93.5 9.0 2.3 1 1 0 1 1 1 1 SGS domain CS PF04969.16 EGD93092.1 - 4e-18 66.2 0.0 8.9e-18 65.1 0.0 1.6 1 0 0 1 1 1 1 CS domain TPR_1 PF00515.28 EGD93092.1 - 0.00024 20.8 1.0 0.0086 15.9 0.0 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 EGD93092.1 - 0.0063 16.5 1.5 1.3 9.4 0.0 2.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 EGD93092.1 - 0.055 13.2 0.0 0.15 11.8 0.0 1.7 1 0 0 1 1 1 0 TPR repeat CcmH PF03918.14 EGD93092.1 - 0.065 12.5 0.2 0.14 11.4 0.2 1.5 1 0 0 1 1 1 0 Cytochrome C biogenesis protein SQHop_cyclase_C PF13243.6 EGD93093.1 - 1.8e-45 155.4 0.2 1.3e-43 149.4 0.1 2.6 2 1 1 3 3 3 1 Squalene-hopene cyclase C-terminal domain SQHop_cyclase_N PF13249.6 EGD93093.1 - 1.1e-43 149.4 1.1 2.5e-37 128.6 0.1 3.4 2 1 1 3 3 3 3 Squalene-hopene cyclase N-terminal domain Prenyltrans PF00432.21 EGD93093.1 - 1.5e-31 107.8 4.3 3e-09 36.5 0.0 5.2 6 0 0 6 6 6 3 Prenyltransferase and squalene oxidase repeat Pec_lyase PF09492.10 EGD93093.1 - 1e-05 25.0 0.8 0.13 11.6 0.1 4.1 2 1 2 4 4 4 3 Pectic acid lyase TED_complement PF07678.14 EGD93093.1 - 0.01 14.9 0.1 0.12 11.4 0.2 2.5 2 1 0 2 2 2 0 A-macroglobulin TED domain Ank_4 PF13637.6 EGD93095.1 - 3.1e-26 91.4 4.4 2.4e-08 34.3 0.0 5.6 4 1 1 5 5 5 5 Ankyrin repeats (many copies) Ank_2 PF12796.7 EGD93095.1 - 1.8e-24 86.1 5.2 6.9e-10 39.4 0.1 4.8 4 2 1 5 5 5 4 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EGD93095.1 - 1.3e-17 63.6 7.7 2e-10 40.7 0.2 6.0 5 1 1 6 6 6 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EGD93095.1 - 3.9e-15 54.5 11.3 1.6e-05 24.9 0.0 9.4 10 1 0 10 10 10 3 Ankyrin repeat Ank PF00023.30 EGD93095.1 - 6.5e-14 51.7 7.6 3.9e-06 27.1 0.1 6.8 6 1 0 6 6 6 2 Ankyrin repeat F-box-like PF12937.7 EGD93095.1 - 0.00016 21.5 0.2 0.00032 20.5 0.2 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EGD93095.1 - 0.00018 21.3 0.3 0.00038 20.3 0.3 1.5 1 0 0 1 1 1 1 F-box domain eIF-6 PF01912.18 EGD93096.1 - 2.5e-79 265.3 0.7 3.2e-79 264.9 0.7 1.1 1 0 0 1 1 1 1 eIF-6 family SRR1 PF07985.12 EGD93097.1 - 7e-14 51.6 0.0 3.8e-13 49.3 0.0 2.3 2 0 0 2 2 2 1 SRR1 Zn_clus PF00172.18 EGD93098.1 - 0.00012 22.1 8.2 0.00025 21.1 8.2 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain COesterase PF00135.28 EGD93098.1 - 0.017 14.0 0.0 0.027 13.4 0.0 1.2 1 0 0 1 1 1 0 Carboxylesterase family TauD PF02668.16 EGD93099.1 - 3.8e-40 138.4 0.0 4.4e-40 138.2 0.0 1.0 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family DUF1330 PF07045.11 EGD93099.1 - 0.096 13.0 0.0 6 7.3 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1330) Pkinase_Tyr PF07714.17 EGD93100.1 - 2.5e-14 53.2 0.0 3.4e-14 52.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EGD93100.1 - 1.2e-11 44.5 0.0 2.3e-11 43.6 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain APH PF01636.23 EGD93100.1 - 0.024 14.6 0.0 0.042 13.8 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Choline_kinase PF01633.20 EGD93100.1 - 0.038 13.6 0.0 0.066 12.8 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase Kdo PF06293.14 EGD93100.1 - 0.045 13.1 0.0 0.072 12.4 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family PHO4 PF01384.20 EGD93101.1 - 7.9e-125 416.4 15.5 9.2e-125 416.2 15.5 1.0 1 0 0 1 1 1 1 Phosphate transporter family Alpha-2-MRAP_C PF06401.11 EGD93101.1 - 0.25 11.3 0.0 0.39 10.7 0.0 1.2 1 0 0 1 1 1 0 Alpha-2-macroglobulin RAP, C-terminal domain Aminotran_1_2 PF00155.21 EGD93102.1 - 7.1e-43 147.1 0.0 8.7e-43 146.9 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 EGD93102.1 - 4.9e-11 41.8 0.0 6.9e-11 41.3 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 EGD93102.1 - 4.6e-09 35.7 0.0 8.3e-09 34.9 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 EGD93102.1 - 1.3e-05 24.7 0.0 1.6e-05 24.3 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase DUF3431 PF11913.8 EGD93103.1 - 4.9e-79 265.1 4.0 1.6e-78 263.4 0.5 2.0 2 0 0 2 2 2 2 Protein of unknown function (DUF3431) XPC-binding PF09280.11 EGD93104.1 - 2.5e-24 84.7 17.2 2.5e-24 84.7 17.2 1.8 2 0 0 2 2 2 1 XPC-binding domain ubiquitin PF00240.23 EGD93104.1 - 3.4e-22 78.0 0.1 6e-22 77.2 0.1 1.4 1 0 0 1 1 1 1 Ubiquitin family UBA PF00627.31 EGD93104.1 - 5.3e-22 77.3 1.9 2.1e-12 46.6 0.1 2.6 2 0 0 2 2 2 2 UBA/TS-N domain Rad60-SLD PF11976.8 EGD93104.1 - 3.7e-08 33.1 0.4 6.7e-08 32.3 0.4 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like UBA_3 PF09288.10 EGD93104.1 - 0.0076 16.0 0.0 2.3 8.1 0.0 2.5 2 0 0 2 2 2 2 Fungal ubiquitin-associated domain Rad60-SLD_2 PF13881.6 EGD93104.1 - 0.032 14.3 0.0 0.062 13.4 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_5 PF18037.1 EGD93104.1 - 0.04 14.3 0.1 0.074 13.4 0.1 1.4 1 0 0 1 1 1 0 Ubiquitin-like domain Ubiquitin_2 PF14560.6 EGD93104.1 - 0.17 12.3 0.0 0.54 10.8 0.0 1.8 1 0 0 1 1 1 0 Ubiquitin-like domain Pheromone PF08015.11 EGD93104.1 - 3 8.9 10.4 5.4 8.1 4.4 2.8 2 0 0 2 2 2 0 Fungal mating-type pheromone Glyco_transf_22 PF03901.17 EGD93105.1 - 3.3e-59 201.2 21.7 5e-59 200.6 21.7 1.2 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family Skp1 PF01466.19 EGD93106.1 - 3e-28 97.7 0.5 4.8e-28 97.0 0.5 1.4 1 0 0 1 1 1 1 Skp1 family, dimerisation domain Skp1_POZ PF03931.15 EGD93106.1 - 1.7e-24 85.7 0.2 4.2e-24 84.5 0.1 1.7 2 0 0 2 2 2 1 Skp1 family, tetramerisation domain DFF-C PF09033.10 EGD93106.1 - 0.044 13.7 0.1 0.081 12.8 0.0 1.5 2 0 0 2 2 2 0 DNA Fragmentation factor 45kDa, C terminal domain Ribosomal_L39 PF00832.20 EGD93107.1 - 4.7e-21 74.1 9.4 6.8e-21 73.6 9.4 1.3 1 0 0 1 1 1 1 Ribosomal L39 protein ABC_membrane PF00664.23 EGD93108.1 - 3.7e-102 341.7 36.0 2.2e-52 178.4 11.7 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EGD93108.1 - 2.2e-68 229.0 0.0 4.4e-33 114.7 0.0 2.7 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EGD93108.1 - 5.3e-15 55.5 0.0 0.00016 21.2 0.0 4.2 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 EGD93108.1 - 2.4e-07 31.3 1.5 0.025 15.0 0.1 3.2 2 2 0 2 2 2 2 AAA ATPase domain AAA_29 PF13555.6 EGD93108.1 - 8.8e-07 28.6 1.0 0.0068 16.1 0.2 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EGD93108.1 - 1.1e-06 28.7 0.0 0.0079 16.1 0.0 2.8 3 0 0 3 3 2 2 RsgA GTPase AAA_22 PF13401.6 EGD93108.1 - 1.8e-06 28.3 1.3 0.054 13.8 0.1 3.8 2 2 0 2 2 2 2 AAA domain ABC_ATPase PF09818.9 EGD93108.1 - 1.9e-05 23.7 1.7 0.1 11.4 0.0 3.4 3 0 0 3 3 3 2 Predicted ATPase of the ABC class AAA_30 PF13604.6 EGD93108.1 - 3.8e-05 23.5 2.0 0.37 10.5 0.2 3.6 3 1 0 3 3 3 2 AAA domain AAA_25 PF13481.6 EGD93108.1 - 0.00011 21.9 0.3 0.089 12.4 0.0 3.0 3 0 0 3 3 3 1 AAA domain AAA PF00004.29 EGD93108.1 - 0.00011 22.6 4.4 0.34 11.3 0.4 4.7 3 2 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) AAA_15 PF13175.6 EGD93108.1 - 0.00016 21.6 0.0 0.094 12.4 0.0 2.8 2 1 0 2 2 2 1 AAA ATPase domain AAA_21 PF13304.6 EGD93108.1 - 0.00016 21.6 3.7 0.92 9.3 0.2 4.4 3 2 1 5 5 5 2 AAA domain, putative AbiEii toxin, Type IV TA system Rad17 PF03215.15 EGD93108.1 - 0.00021 21.3 0.1 0.088 12.7 0.0 2.6 2 0 0 2 2 2 1 Rad17 P-loop domain AAA_7 PF12775.7 EGD93108.1 - 0.00063 19.3 0.0 1.4 8.4 0.0 2.4 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA_5 PF07728.14 EGD93108.1 - 0.00069 19.6 0.2 0.83 9.7 0.0 3.0 3 0 0 3 3 2 1 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 EGD93108.1 - 0.002 18.7 0.0 1.9 9.1 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EGD93108.1 - 0.0024 18.0 0.1 2.6 8.2 0.0 2.7 2 0 0 2 2 2 1 AAA domain SRP54 PF00448.22 EGD93108.1 - 0.003 17.2 0.1 1.5 8.5 0.0 2.7 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain Zeta_toxin PF06414.12 EGD93108.1 - 0.003 16.8 0.0 3.8 6.7 0.0 2.9 2 0 0 2 2 2 2 Zeta toxin AAA_23 PF13476.6 EGD93108.1 - 0.0032 18.0 4.4 1.5 9.3 0.0 4.0 3 1 0 3 3 3 1 AAA domain AAA_24 PF13479.6 EGD93108.1 - 0.0079 15.9 0.0 3.5 7.3 0.0 2.5 2 0 0 2 2 2 1 AAA domain SbcCD_C PF13558.6 EGD93108.1 - 0.011 16.0 3.5 6.7 7.0 0.5 3.9 2 2 0 2 2 2 0 Putative exonuclease SbcCD, C subunit PRK PF00485.18 EGD93108.1 - 0.016 15.0 0.1 2.3 7.9 0.0 2.5 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family RNA_helicase PF00910.22 EGD93108.1 - 0.019 15.4 0.0 5.2 7.5 0.0 3.0 2 0 0 2 2 2 0 RNA helicase AAA_28 PF13521.6 EGD93108.1 - 0.051 13.8 0.9 6 7.1 0.1 2.7 2 0 0 2 2 2 0 AAA domain SAA PF00277.18 EGD93108.1 - 0.059 13.9 1.4 1.2 9.7 0.0 2.8 3 0 0 3 3 2 0 Serum amyloid A protein APS_kinase PF01583.20 EGD93108.1 - 0.064 13.1 0.1 2.3 8.1 0.0 2.7 2 0 0 2 2 2 0 Adenylylsulphate kinase G-alpha PF00503.20 EGD93108.1 - 0.078 12.1 0.0 11 5.1 0.0 2.3 2 0 0 2 2 2 0 G-protein alpha subunit Cytidylate_kin PF02224.18 EGD93108.1 - 0.081 12.6 0.9 5.4 6.7 0.2 2.8 2 1 0 2 2 2 0 Cytidylate kinase AAA_17 PF13207.6 EGD93108.1 - 0.13 12.7 0.2 46 4.4 0.0 3.2 3 0 0 3 3 3 0 AAA domain DUF87 PF01935.17 EGD93108.1 - 0.72 9.9 4.0 4.4 7.3 0.1 3.0 3 0 0 3 3 3 0 Helicase HerA, central domain MFS_1 PF07690.16 EGD93110.1 - 7.1e-61 206.1 57.5 2.6e-44 151.6 29.9 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 EGD93110.1 - 4e-06 25.9 21.8 0.00066 18.6 4.4 3.9 1 1 3 4 4 4 3 MFS_1 like family Asp-Al_Ex PF06826.12 EGD93110.1 - 0.0038 17.1 5.9 0.0038 17.1 5.9 3.3 2 1 1 3 3 3 1 Predicted Permease Membrane Region OATP PF03137.20 EGD93110.1 - 0.0085 14.4 0.0 0.0085 14.4 0.0 3.0 3 1 0 3 3 3 2 Organic Anion Transporter Polypeptide (OATP) family MFS_4 PF06779.14 EGD93110.1 - 0.077 12.3 26.2 0.06 12.6 7.4 3.6 2 2 1 3 3 3 0 Uncharacterised MFS-type transporter YbfB MFS_3 PF05977.13 EGD93110.1 - 3.1 6.1 21.4 0.018 13.5 5.4 2.9 2 2 0 2 2 2 0 Transmembrane secretion effector tRNA-synt_2c PF01411.19 EGD93111.1 - 1.1e-09 37.4 0.1 1.4e-09 37.0 0.1 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (A) tRNA_SAD PF07973.14 EGD93111.1 - 4.9e-06 26.5 0.7 8.1e-06 25.8 0.7 1.4 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain WD40 PF00400.32 EGD93112.1 - 7.8e-22 77.2 6.2 1.4e-05 25.7 0.0 8.3 8 1 0 8 8 8 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EGD93112.1 - 9.3e-17 61.1 0.0 0.0018 18.5 0.0 6.4 4 2 3 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain Peptidase_S8 PF00082.22 EGD93112.1 - 3.3e-14 52.8 0.0 1.7e-13 50.5 0.0 2.0 1 1 0 1 1 1 1 Subtilase family PD40 PF07676.12 EGD93112.1 - 2.2e-09 37.0 0.6 29 4.8 0.0 8.6 9 0 0 9 9 9 0 WD40-like Beta Propeller Repeat NACHT PF05729.12 EGD93112.1 - 5.4e-07 29.7 0.9 4.5e-06 26.7 0.2 2.4 2 0 0 2 2 2 1 NACHT domain AAA_16 PF13191.6 EGD93112.1 - 6.6e-05 23.4 0.0 0.00025 21.5 0.0 2.0 1 0 0 1 1 1 1 AAA ATPase domain KAP_NTPase PF07693.14 EGD93112.1 - 0.00011 21.6 0.0 0.00018 20.9 0.0 1.3 1 0 0 1 1 1 1 KAP family P-loop domain Ge1_WD40 PF16529.5 EGD93112.1 - 0.0017 17.4 0.0 1.6 7.6 0.0 4.0 4 1 1 5 5 5 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Nbas_N PF15492.6 EGD93112.1 - 0.0062 15.9 0.5 8.9 5.5 0.0 4.0 4 1 1 5 5 5 1 Neuroblastoma-amplified sequence, N terminal Nup160 PF11715.8 EGD93112.1 - 0.011 14.4 0.2 0.4 9.3 0.1 2.8 3 0 0 3 3 3 0 Nucleoporin Nup120/160 DUF1513 PF07433.11 EGD93112.1 - 0.015 14.4 0.0 0.44 9.6 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1513) AAA_30 PF13604.6 EGD93112.1 - 0.034 13.9 0.0 0.084 12.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain Proteasome_A_N PF10584.9 EGD93112.1 - 0.038 13.7 8.6 8.1 6.2 0.0 5.9 6 0 0 6 6 6 0 Proteasome subunit A N-terminal signature PALB2_WD40 PF16756.5 EGD93112.1 - 0.13 11.2 0.1 7 5.5 0.1 2.5 2 0 0 2 2 2 0 Partner and localizer of BRCA2 WD40 domain Glyco_transf_54 PF04666.13 EGD93114.1 - 1.3e-10 40.7 0.0 8.2e-10 38.0 0.0 1.9 1 1 0 1 1 1 1 N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region EamA PF00892.20 EGD93114.1 - 0.17 12.1 3.6 3.1 8.0 0.2 2.3 2 0 0 2 2 2 0 EamA-like transporter family MUG113 PF13455.6 EGD93115.1 - 5.2e-21 75.1 0.5 9.8e-21 74.2 0.5 1.5 1 0 0 1 1 1 1 Meiotically up-regulated gene 113 T5orf172 PF10544.9 EGD93115.1 - 2.6e-20 72.9 0.2 6.6e-20 71.6 0.1 1.8 2 0 0 2 2 2 1 T5orf172 domain Promethin PF16015.5 EGD93116.1 - 6.5e-27 93.5 17.5 8.7e-27 93.1 17.5 1.2 1 0 0 1 1 1 1 Promethin Spc42p PF11544.8 EGD93117.1 - 0.082 12.9 9.2 0.73 9.9 9.2 2.8 1 0 0 1 1 1 0 Spindle pole body component Spc42p Sas6_CC PF18594.1 EGD93117.1 - 0.73 9.7 8.0 0.11 12.3 0.5 3.3 3 0 0 3 3 3 0 Sas6/XLF/XRCC4 coiled-coil domain SseC PF04888.12 EGD93117.1 - 2.5 7.6 11.8 6.9 6.2 11.7 1.8 1 1 0 1 1 1 0 Secretion system effector C (SseC) like family Exonuc_VII_L PF02601.15 EGD93117.1 - 7.2 6.1 28.6 1.1 8.8 16.3 2.2 1 1 1 2 2 2 0 Exonuclease VII, large subunit SlyX PF04102.12 EGD93117.1 - 8.8 7.0 20.0 0.2 12.3 8.1 4.2 3 1 1 4 4 4 0 SlyX SecY PF00344.20 EGD93118.1 - 1e-64 218.7 4.3 1.3e-64 218.4 4.3 1.0 1 0 0 1 1 1 1 SecY translocase ArgJ PF01960.18 EGD93119.1 - 1.6e-150 501.0 0.0 1.8e-150 500.9 0.0 1.0 1 0 0 1 1 1 1 ArgJ family ORC2 PF04084.14 EGD93120.1 - 2.5e-116 388.2 0.0 3.1e-116 387.9 0.0 1.1 1 0 0 1 1 1 1 Origin recognition complex subunit 2 AT_hook PF02178.19 EGD93120.1 - 3.8 7.7 9.4 12 6.2 9.4 1.9 1 0 0 1 1 1 0 AT hook motif FUN14 PF04930.15 EGD93121.1 - 2.4e-08 34.3 0.4 4.8e-08 33.3 0.4 1.5 1 1 0 1 1 1 1 FUN14 family TMEM43 PF07787.12 EGD93121.1 - 0.15 11.4 1.2 0.93 8.8 0.7 2.0 2 0 0 2 2 2 0 Transmembrane protein 43 SOR_SNZ PF01680.17 EGD93122.1 - 7.8e-108 359.0 5.2 1.3e-107 358.2 5.2 1.3 1 0 0 1 1 1 1 SOR/SNZ family ThiG PF05690.14 EGD93122.1 - 4.8e-09 35.9 8.5 1.3e-07 31.1 0.1 2.7 3 1 1 4 4 4 2 Thiazole biosynthesis protein ThiG Dus PF01207.17 EGD93122.1 - 0.0019 17.4 0.6 0.32 10.0 0.0 2.6 2 1 0 2 2 2 2 Dihydrouridine synthase (Dus) His_biosynth PF00977.21 EGD93122.1 - 0.0022 17.5 0.2 0.032 13.7 0.0 2.5 2 1 0 2 2 2 1 Histidine biosynthesis protein TetR_C_27 PF17935.1 EGD93122.1 - 0.0039 17.2 0.0 0.01 15.9 0.0 1.6 1 0 0 1 1 1 1 Tetracyclin repressor-like, C-terminal domain IGPS PF00218.21 EGD93122.1 - 0.0083 15.3 0.0 0.35 10.0 0.0 2.5 2 1 0 2 2 2 1 Indole-3-glycerol phosphate synthase TMP-TENI PF02581.17 EGD93122.1 - 0.017 14.5 0.7 0.62 9.4 0.0 3.1 3 0 0 3 3 3 0 Thiamine monophosphate synthase NanE PF04131.14 EGD93122.1 - 0.024 13.8 0.8 0.26 10.5 0.0 2.4 2 1 0 2 2 2 0 Putative N-acetylmannosamine-6-phosphate epimerase OMPdecase PF00215.24 EGD93122.1 - 0.044 13.4 0.1 0.39 10.3 0.0 2.2 1 1 2 3 3 3 0 Orotidine 5'-phosphate decarboxylase / HUMPS family Xpo1 PF08389.12 EGD93124.1 - 0.019 15.0 0.0 0.21 11.6 0.0 2.6 2 0 0 2 2 2 0 Exportin 1-like protein Importin_rep_3 PF18806.1 EGD93124.1 - 0.023 14.7 0.0 0.55 10.3 0.0 2.6 2 0 0 2 2 2 0 Importin 13 repeat Bcl-2 PF00452.19 EGD93124.1 - 0.075 13.7 0.2 29 5.4 0.0 3.8 3 0 0 3 3 3 0 Apoptosis regulator proteins, Bcl-2 family Creatinase_N_2 PF16189.5 EGD93125.1 - 5.4e-53 179.4 0.1 1.1e-51 175.2 0.1 2.3 2 0 0 2 2 2 1 Creatinase/Prolidase N-terminal domain Peptidase_M24 PF00557.24 EGD93125.1 - 7.2e-41 140.2 0.0 1.1e-40 139.5 0.0 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 Peptidase_M24_C PF16188.5 EGD93125.1 - 2.8e-25 88.1 0.3 9.9e-25 86.4 0.3 2.0 2 0 0 2 2 2 1 C-terminal region of peptidase_M24 Creatinase_N PF01321.18 EGD93125.1 - 3.7e-19 69.7 0.0 8.9e-16 58.7 0.0 2.5 2 0 0 2 2 2 2 Creatinase/Prolidase N-terminal domain Pga1 PF10333.9 EGD93126.1 - 0.0016 18.3 0.0 0.0024 17.8 0.0 1.4 1 0 0 1 1 1 1 GPI-Mannosyltransferase II co-activator Tubulin PF00091.25 EGD93127.1 - 6.9e-65 218.9 0.0 1.1e-64 218.3 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EGD93127.1 - 5.2e-48 162.4 0.2 9.7e-48 161.5 0.2 1.5 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 EGD93127.1 - 0.0017 18.0 0.0 0.005 16.5 0.0 1.8 2 0 0 2 2 2 1 Tubulin domain EF-hand_4 PF12763.7 EGD93128.1 - 7.7e-39 131.8 0.0 1.6e-15 56.9 0.0 3.4 3 0 0 3 3 3 3 Cytoskeletal-regulatory complex EF hand EF-hand_7 PF13499.6 EGD93128.1 - 8.9e-09 35.7 0.0 4e-05 24.0 0.0 4.2 2 1 1 3 3 3 1 EF-hand domain pair EF-hand_1 PF00036.32 EGD93128.1 - 8.2e-07 28.1 1.3 0.022 14.3 0.0 6.0 7 0 0 7 7 7 1 EF hand EF-hand_6 PF13405.6 EGD93128.1 - 3.3e-05 23.5 1.0 9.2 6.5 0.0 6.3 6 0 0 6 6 6 1 EF-hand domain UBA PF00627.31 EGD93128.1 - 6.4e-05 22.8 0.1 0.00012 21.9 0.1 1.5 1 0 0 1 1 1 1 UBA/TS-N domain EF-hand_8 PF13833.6 EGD93128.1 - 0.0031 17.3 0.2 0.091 12.6 0.0 3.5 4 0 0 4 4 4 1 EF-hand domain pair BicD PF09730.9 EGD93128.1 - 0.0079 14.7 26.8 0.064 11.7 26.3 2.0 1 1 0 1 1 1 1 Microtubule-associated protein Bicaudal-D GAS PF13851.6 EGD93128.1 - 0.0086 15.4 32.4 0.049 13.0 18.3 2.7 1 1 0 2 2 2 2 Growth-arrest specific micro-tubule binding DUF3450 PF11932.8 EGD93128.1 - 0.46 9.7 35.4 0.11 11.8 14.0 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) TMF_TATA_bd PF12325.8 EGD93128.1 - 0.5 10.6 29.8 0.095 12.9 4.6 3.4 1 1 2 3 3 3 0 TATA element modulatory factor 1 TATA binding CALCOCO1 PF07888.11 EGD93128.1 - 0.93 8.3 27.5 1.4 7.7 27.5 1.1 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like FPP PF05911.11 EGD93128.1 - 1.2 7.2 24.6 1.9 6.6 24.6 1.2 1 0 0 1 1 1 0 Filament-like plant protein, long coiled-coil CENP-F_leu_zip PF10473.9 EGD93128.1 - 1.3 9.1 31.6 0.25 11.3 12.1 2.4 1 1 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ATG16 PF08614.11 EGD93128.1 - 2 8.6 38.4 2.8 8.1 15.0 2.7 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) IFT57 PF10498.9 EGD93128.1 - 3.3 6.6 20.8 18 4.2 20.8 1.9 1 1 0 1 1 1 0 Intra-flagellar transport protein 57 Fib_alpha PF08702.10 EGD93128.1 - 3.5 7.8 21.2 0.027 14.7 8.0 2.4 1 1 0 2 2 2 0 Fibrinogen alpha/beta chain family Spc7 PF08317.11 EGD93128.1 - 3.8 6.3 33.8 1.3 7.8 10.9 2.2 1 1 1 2 2 2 0 Spc7 kinetochore protein Cep57_MT_bd PF06657.13 EGD93128.1 - 8.6 6.9 13.2 0.15 12.5 3.6 2.8 1 1 2 3 3 3 0 Centrosome microtubule-binding domain of Cep57 MARVEL PF01284.23 EGD93129.1 - 7.3e-17 61.7 21.0 9.2e-17 61.4 21.0 1.1 1 0 0 1 1 1 1 Membrane-associating domain Sulfotransfer_4 PF17784.1 EGD93130.1 - 1.5e-71 240.6 0.0 1.8e-71 240.4 0.0 1.1 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 EGD93130.1 - 4e-05 24.1 0.5 0.085 13.2 0.0 2.6 1 1 1 2 2 2 2 Sulfotransferase family Cys_Met_Meta_PP PF01053.20 EGD93131.1 - 1e-144 481.8 0.0 1.2e-144 481.6 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 EGD93131.1 - 8.8e-13 48.3 0.2 1.7e-12 47.3 0.2 1.4 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_1_2 PF00155.21 EGD93131.1 - 4.5e-09 36.0 0.1 7.3e-09 35.3 0.1 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 EGD93131.1 - 1.5e-07 30.7 0.2 2.7e-07 29.9 0.2 1.4 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 EGD93131.1 - 0.0009 18.6 0.0 0.0015 17.9 0.0 1.4 1 0 0 1 1 1 1 Beta-eliminating lyase Asparaginase_C PF17763.1 EGD93131.1 - 0.024 14.9 0.1 0.092 13.0 0.0 2.0 3 0 0 3 3 3 0 Glutaminase/Asparaginase C-terminal domain SepSecS PF05889.13 EGD93131.1 - 0.036 12.8 0.0 0.054 12.2 0.0 1.2 1 0 0 1 1 1 0 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS AMP-binding PF00501.28 EGD93132.1 - 8.8e-83 278.2 0.0 1.1e-82 278.0 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme DUF2012 PF09430.10 EGD93133.1 - 6.8e-24 84.3 0.0 9.5e-24 83.9 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2012) SOP4 PF17081.5 EGD93133.1 - 0.093 12.3 0.0 0.35 10.4 0.0 1.8 2 0 0 2 2 2 0 Suppressor of PMA 1-7 protein LCCL PF03815.19 EGD93134.1 - 5.1e-20 71.4 0.1 8.2e-20 70.7 0.1 1.3 1 0 0 1 1 1 1 LCCL domain CENP-B_dimeris PF09026.10 EGD93134.1 - 0.09 13.2 2.4 0.17 12.3 2.4 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DUF3328 PF11807.8 EGD93136.1 - 6.5e-48 163.4 0.4 7.9e-48 163.1 0.4 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) Ank_2 PF12796.7 EGD93137.1 - 3.2e-34 117.4 4.9 9.9e-22 77.3 0.4 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EGD93137.1 - 1.5e-29 102.0 3.3 3.1e-15 56.3 0.2 3.1 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 EGD93137.1 - 1.1e-19 70.2 2.6 1.9e-07 31.2 0.1 3.1 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 EGD93137.1 - 2.8e-18 65.5 1.9 3e-06 27.4 0.0 3.4 3 0 0 3 3 3 3 Ankyrin repeat Ank_3 PF13606.6 EGD93137.1 - 9.1e-16 56.4 0.1 1.9e-06 27.8 0.0 3.4 3 0 0 3 3 3 2 Ankyrin repeat bZIP_1 PF00170.21 EGD93137.1 - 0.0071 16.4 8.8 0.013 15.6 8.8 1.4 1 0 0 1 1 1 1 bZIP transcription factor VWA_3_C PF18571.1 EGD93137.1 - 0.056 13.3 0.9 2.3 8.2 0.1 2.5 2 0 0 2 2 2 0 von Willebrand factor type A C-terminal domain NACHT_N PF17100.5 EGD93137.1 - 0.11 12.3 0.3 0.16 11.8 0.3 1.2 1 0 0 1 1 1 0 N-terminal domain of NWD NACHT-NTPase PTR2 PF00854.21 EGD93138.1 - 3.4e-78 263.2 8.9 4.5e-78 262.8 8.9 1.1 1 0 0 1 1 1 1 POT family Methyltransf_32 PF13679.6 EGD93140.1 - 1.3e-20 74.0 1.3 5e-20 72.1 1.3 1.9 1 1 0 1 1 1 1 Methyltransferase domain Syntaxin-6_N PF09177.11 EGD93141.1 - 4.6e-24 84.8 1.1 1.3e-23 83.4 0.1 2.0 2 0 0 2 2 2 1 Syntaxin 6, N-terminal APG17 PF04108.12 EGD93141.1 - 0.0024 17.1 3.0 0.065 12.3 0.2 2.2 2 0 0 2 2 2 2 Autophagy protein Apg17 SNARE PF05739.19 EGD93141.1 - 0.0026 17.7 1.4 0.0059 16.6 1.4 1.6 1 0 0 1 1 1 1 SNARE domain DUF3618 PF12277.8 EGD93141.1 - 0.0045 17.2 7.3 0.98 9.7 0.1 3.7 3 0 0 3 3 3 2 Protein of unknown function (DUF3618) HMMR_N PF15905.5 EGD93141.1 - 0.026 14.0 0.1 0.026 14.0 0.1 2.0 2 0 0 2 2 2 0 Hyaluronan mediated motility receptor N-terminal DUF4795 PF16043.5 EGD93141.1 - 0.037 13.6 0.8 0.9 9.1 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4795) Phage_int_SAM_2 PF12834.7 EGD93141.1 - 0.12 13.1 0.1 0.33 11.7 0.1 1.7 1 0 0 1 1 1 0 Phage integrase, N-terminal Vps51 PF08700.11 EGD93141.1 - 0.14 12.2 3.9 10 6.3 0.0 3.3 3 1 0 3 3 3 0 Vps51/Vps67 Laminin_II PF06009.12 EGD93141.1 - 0.15 12.1 1.3 4.1 7.4 0.1 2.4 2 1 0 2 2 2 0 Laminin Domain II DUF4726 PF15855.5 EGD93141.1 - 0.27 11.5 0.1 0.27 11.5 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4726) Cnn_1N PF07989.11 EGD93141.1 - 0.35 11.1 8.0 7.7 6.7 1.4 3.3 3 0 0 3 3 3 0 Centrosomin N-terminal motif 1 YtxH PF12732.7 EGD93141.1 - 0.51 10.9 3.0 2.7 8.6 0.5 2.5 2 1 0 2 2 2 0 YtxH-like protein DUF883 PF05957.13 EGD93141.1 - 0.52 10.9 5.0 22 5.7 0.0 3.3 3 1 0 3 3 3 0 Bacterial protein of unknown function (DUF883) SOAR PF16533.5 EGD93141.1 - 0.9 9.6 3.5 16 5.6 0.6 3.1 3 0 0 3 3 3 0 STIM1 Orai1-activating region GCIP PF13324.6 EGD93141.1 - 0.99 9.0 5.7 0.52 9.9 2.4 2.1 2 1 0 2 2 2 0 Grap2 and cyclin-D-interacting Spc7 PF08317.11 EGD93141.1 - 1.5 7.7 6.2 1.7 7.5 0.2 2.2 2 0 0 2 2 2 0 Spc7 kinetochore protein NAP PF00956.18 EGD93142.1 - 3.1e-19 69.2 7.0 3.1e-19 69.2 7.0 2.3 2 1 1 3 3 3 1 Nucleosome assembly protein (NAP) NmrA PF05368.13 EGD93143.1 - 6.5e-69 232.0 0.0 7.9e-69 231.8 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family DUF1876 PF08962.11 EGD93143.1 - 0.18 11.8 1.5 0.23 11.4 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF1876) Asparaginase PF00710.20 EGD93144.1 - 2.8e-57 193.4 0.0 4e-57 192.9 0.0 1.2 1 0 0 1 1 1 1 Asparaginase, N-terminal Asparaginase_C PF17763.1 EGD93144.1 - 4.5e-30 104.2 0.2 2e-29 102.1 0.3 1.9 2 0 0 2 2 2 1 Glutaminase/Asparaginase C-terminal domain MTTB PF06253.11 EGD93144.1 - 0.013 13.5 0.1 0.019 13.0 0.1 1.1 1 0 0 1 1 1 0 Trimethylamine methyltransferase (MTTB) 2-Hacid_dh_C PF02826.19 EGD93145.1 - 1e-46 158.6 0.1 1.5e-46 158.0 0.1 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_2 PF03446.15 EGD93145.1 - 3.7e-06 27.2 0.1 5.2e-06 26.7 0.1 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 EGD93145.1 - 0.00046 20.7 0.1 0.00087 19.8 0.1 1.5 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent 2-Hacid_dh PF00389.30 EGD93145.1 - 0.12 12.0 0.0 0.21 11.3 0.0 1.3 1 1 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain Rossmann-like PF10727.9 EGD93145.1 - 0.14 12.0 2.7 0.26 11.2 2.7 1.4 1 0 0 1 1 1 0 Rossmann-like domain Peptidase_S8 PF00082.22 EGD93146.1 - 3.2e-25 89.0 1.9 4.2e-25 88.6 0.4 2.0 2 1 0 2 2 2 1 Subtilase family Ecl1 PF12855.7 EGD93149.1 - 0.2 12.8 4.3 0.39 11.9 4.3 1.4 1 0 0 1 1 1 0 ECL1/2/3 zinc binding proteins APH PF01636.23 EGD93150.1 - 1.2e-09 38.5 0.0 5e-09 36.4 0.0 1.9 1 1 0 1 1 1 1 Phosphotransferase enzyme family MBR1 PF17058.5 EGD93151.1 - 0.86 9.9 11.8 0.02 15.2 4.7 1.8 2 0 0 2 2 2 0 Mitochondrial biogenesis regulation protein 1 ARL17 PF15840.5 EGD93152.1 - 0.0017 18.7 0.3 0.0029 17.9 0.3 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor-like protein 17 DUF1996 PF09362.10 EGD93153.1 - 5.2e-84 281.9 0.0 9.5e-84 281.0 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1996) AdoMet_MTase PF07757.13 EGD93153.1 - 0.016 15.5 0.0 0.029 14.7 0.0 1.3 1 0 0 1 1 1 0 Predicted AdoMet-dependent methyltransferase adh_short_C2 PF13561.6 EGD93154.1 - 1.3e-62 211.4 0.0 1.7e-62 211.1 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EGD93154.1 - 3.8e-52 176.6 0.3 4.8e-52 176.3 0.3 1.0 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EGD93154.1 - 7.2e-05 22.8 0.7 0.00019 21.4 0.7 1.6 1 1 0 1 1 1 1 KR domain HI0933_like PF03486.14 EGD93154.1 - 0.044 12.5 0.2 0.053 12.2 0.2 1.2 1 0 0 1 1 1 0 HI0933-like protein AA_permease_2 PF13520.6 EGD93155.1 - 8.8e-41 140.1 50.5 1.1e-40 139.8 50.5 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EGD93155.1 - 1e-16 60.6 40.6 1.4e-16 60.2 40.6 1.0 1 0 0 1 1 1 1 Amino acid permease ELO PF01151.18 EGD93158.1 - 1.3e-56 191.9 22.1 1.7e-55 188.3 22.1 2.0 1 1 0 1 1 1 1 GNS1/SUR4 family COX5A PF02284.16 EGD93159.1 - 2.1e-38 130.5 0.8 2.7e-38 130.1 0.8 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit Va DUF4972 PF16342.5 EGD93159.1 - 0.11 12.2 0.0 0.17 11.6 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4972) WD40_4 PF16300.5 EGD93159.1 - 0.13 12.2 0.0 9.8 6.2 0.0 2.4 2 0 0 2 2 2 0 Type of WD40 repeat ABC_membrane PF00664.23 EGD93160.1 - 2.2e-74 250.6 32.4 1.8e-46 159.0 10.7 3.1 3 0 0 3 3 3 3 ABC transporter transmembrane region ABC_tran PF00005.27 EGD93160.1 - 4e-66 221.7 0.0 6.7e-32 110.9 0.1 2.5 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EGD93160.1 - 2.5e-16 59.8 2.7 1.9e-05 24.2 0.0 4.3 4 0 0 4 4 4 3 RecF/RecN/SMC N terminal domain ABC_ATPase PF09818.9 EGD93160.1 - 7.2e-10 38.2 0.3 0.0022 16.8 0.0 3.1 3 0 0 3 3 3 2 Predicted ATPase of the ABC class AAA_29 PF13555.6 EGD93160.1 - 4.6e-09 35.9 0.7 0.0019 17.9 0.0 3.0 3 0 0 3 3 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 EGD93160.1 - 6.7e-08 33.1 0.7 0.002 18.5 0.1 2.8 2 0 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.6 EGD93160.1 - 8.2e-08 32.6 2.1 0.097 13.0 0.0 4.2 3 1 0 4 4 3 2 AAA domain DUF87 PF01935.17 EGD93160.1 - 1.7e-07 31.6 0.4 0.0013 18.9 0.0 2.9 3 0 0 3 3 3 2 Helicase HerA, central domain AAA_15 PF13175.6 EGD93160.1 - 1.3e-05 25.1 0.0 0.057 13.1 0.0 2.4 2 0 0 2 2 2 2 AAA ATPase domain AAA_30 PF13604.6 EGD93160.1 - 4.8e-05 23.2 1.1 0.13 12.0 0.0 3.7 3 1 0 3 3 3 2 AAA domain RsgA_GTPase PF03193.16 EGD93160.1 - 7.6e-05 22.7 0.0 0.56 10.1 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase DUF3987 PF13148.6 EGD93160.1 - 0.00023 20.3 0.0 0.16 10.9 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF3987) AAA_21 PF13304.6 EGD93160.1 - 0.00029 20.7 1.2 4.3 7.0 0.0 3.6 4 0 0 4 4 4 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_18 PF13238.6 EGD93160.1 - 0.00069 20.2 0.0 0.41 11.2 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_23 PF13476.6 EGD93160.1 - 0.00074 20.1 0.5 2.2 8.7 0.0 2.8 3 0 0 3 3 2 2 AAA domain Zeta_toxin PF06414.12 EGD93160.1 - 0.0014 17.9 0.8 0.65 9.2 0.0 3.1 3 0 0 3 3 3 1 Zeta toxin G-alpha PF00503.20 EGD93160.1 - 0.0023 17.2 0.0 0.99 8.5 0.0 2.3 2 0 0 2 2 2 2 G-protein alpha subunit AAA_33 PF13671.6 EGD93160.1 - 0.0026 17.9 0.1 1.8 8.7 0.0 2.6 2 0 0 2 2 2 1 AAA domain FtsK_SpoIIIE PF01580.18 EGD93160.1 - 0.0036 16.7 0.0 0.045 13.1 0.0 2.3 2 0 0 2 2 2 1 FtsK/SpoIIIE family AAA_5 PF07728.14 EGD93160.1 - 0.0059 16.6 0.1 6.6 6.7 0.0 3.1 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) SRP54 PF00448.22 EGD93160.1 - 0.0094 15.6 1.1 0.78 9.3 0.0 2.7 3 0 0 3 3 2 1 SRP54-type protein, GTPase domain AAA_25 PF13481.6 EGD93160.1 - 0.011 15.4 0.0 2.9 7.4 0.0 2.8 3 0 0 3 3 2 0 AAA domain AAA_28 PF13521.6 EGD93160.1 - 0.017 15.3 0.2 3.7 7.7 0.0 2.7 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 EGD93160.1 - 0.018 14.7 0.1 7.2 6.3 0.0 2.5 2 0 0 2 2 2 0 AAA domain TrwB_AAD_bind PF10412.9 EGD93160.1 - 0.028 13.4 0.1 1.2 7.9 0.0 2.9 3 0 0 3 3 3 0 Type IV secretion-system coupling protein DNA-binding domain SbcCD_C PF13558.6 EGD93160.1 - 0.045 14.0 4.8 4.7 7.5 0.3 3.8 2 2 0 2 2 2 0 Putative exonuclease SbcCD, C subunit PRK PF00485.18 EGD93160.1 - 0.065 13.0 0.7 13 5.5 0.1 2.4 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family Rad17 PF03215.15 EGD93160.1 - 0.07 13.1 0.0 2.8 7.8 0.0 2.4 2 0 0 2 2 2 0 Rad17 P-loop domain MTH865 PF07747.11 EGD93160.1 - 0.076 12.8 0.0 6.4 6.6 0.0 2.5 2 0 0 2 2 2 0 MTH865-like family AAA_7 PF12775.7 EGD93160.1 - 0.079 12.5 0.0 13 5.2 0.0 2.8 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_17 PF13207.6 EGD93160.1 - 0.11 12.9 0.1 25 5.3 0.0 3.1 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 EGD93160.1 - 0.17 12.0 0.1 28 4.8 0.0 2.8 2 0 0 2 2 2 0 50S ribosome-binding GTPase FERM_N PF09379.10 EGD93160.1 - 0.17 11.8 0.1 0.54 10.2 0.1 1.9 1 0 0 1 1 1 0 FERM N-terminal domain ATP_bind_1 PF03029.17 EGD93160.1 - 0.3 10.8 1.7 11 5.7 0.0 2.8 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein Acetyltransf_8 PF13523.6 EGD93162.1 - 9.8e-44 148.6 0.7 1.4e-43 148.1 0.7 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain CLASP_N PF12348.8 EGD93163.1 - 1.2e-150 499.3 3.6 1.1e-92 309.7 0.0 3.0 3 1 1 4 4 4 2 CLASP N terminal Cnd1 PF12717.7 EGD93163.1 - 2.5e-06 27.6 0.0 0.044 13.8 0.0 4.2 3 1 1 4 4 4 2 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 EGD93163.1 - 5.5e-06 26.2 0.7 5.3 7.6 0.0 6.5 7 0 0 7 7 7 2 HEAT repeat BSP PF04450.12 EGD93164.1 - 5.1e-65 219.1 0.0 6e-65 218.9 0.0 1.0 1 0 0 1 1 1 1 Peptidase of plants and bacteria Ribonucleas_3_3 PF14622.6 EGD93166.1 - 9.3e-07 29.1 0.0 0.0039 17.3 0.0 2.3 2 0 0 2 2 2 2 Ribonuclease-III-like dsrm PF00035.26 EGD93166.1 - 4.8e-06 27.2 0.0 8.6e-06 26.4 0.0 1.4 1 0 0 1 1 1 1 Double-stranded RNA binding motif Ribonuclease_3 PF00636.26 EGD93166.1 - 0.00013 22.5 0.0 0.00025 21.6 0.0 1.5 1 0 0 1 1 1 1 Ribonuclease III domain PfkB PF00294.24 EGD93168.1 - 3.2e-11 43.1 0.0 5.4e-11 42.3 0.0 1.3 1 0 0 1 1 1 1 pfkB family carbohydrate kinase CAP_N PF01213.19 EGD93169.1 - 1.8e-82 277.3 0.3 1.8e-82 277.3 0.3 1.5 1 1 1 2 2 2 1 Adenylate cyclase associated (CAP) N terminal CAP_C PF08603.11 EGD93169.1 - 9.1e-55 184.6 1.6 1.2e-54 184.2 1.6 1.1 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal TBCC PF07986.12 EGD93169.1 - 0.033 13.9 3.2 1.2 8.9 2.6 2.2 1 1 1 2 2 2 0 Tubulin binding cofactor C Ribosomal_60s PF00428.19 EGD93169.1 - 0.47 11.1 4.4 0.21 12.2 1.5 1.8 2 0 0 2 2 2 0 60s Acidic ribosomal protein PRIMA1 PF16101.5 EGD93169.1 - 4.8 7.2 13.5 0.95 9.5 9.2 2.0 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 DUF4210 PF13915.6 EGD93170.1 - 4.8e-33 113.6 0.1 1.4e-32 112.0 0.1 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF4210) Chromosome_seg PF13889.6 EGD93170.1 - 9.3e-22 77.0 1.0 2.3e-21 75.7 0.2 2.1 2 0 0 2 2 2 1 Chromosome segregation during meiosis rRNA_processing PF08524.11 EGD93171.1 - 0.00079 19.5 11.6 0.00079 19.5 11.6 2.5 1 1 1 2 2 2 1 rRNA processing Serglycin PF04360.12 EGD93171.1 - 0.031 14.2 0.0 0.044 13.7 0.0 1.3 1 0 0 1 1 1 0 Serglycin GCP_C_terminal PF04130.13 EGD93172.1 - 3.1e-67 227.2 0.0 4.4e-67 226.7 0.0 1.2 1 0 0 1 1 1 1 Gamma tubulin complex component C-terminal GCP_N_terminal PF17681.1 EGD93172.1 - 3.5e-33 115.5 0.0 4e-32 112.1 0.0 2.5 2 1 0 2 2 2 1 Gamma tubulin complex component N-terminal Eaf7 PF07904.13 EGD93173.1 - 4.2e-29 101.0 0.0 8.6e-29 100.0 0.0 1.5 1 0 0 1 1 1 1 Chromatin modification-related protein EAF7 Iso_dh PF00180.20 EGD93174.1 - 1.9e-101 339.7 0.0 2.4e-101 339.4 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Phage_30_3 PF08010.11 EGD93174.1 - 0.0088 15.9 0.0 0.017 14.9 0.0 1.4 1 0 0 1 1 1 1 Bacteriophage protein GP30.3 Sec5 PF15469.6 EGD93175.1 - 1.8e-35 122.5 0.0 6.3e-35 120.7 0.0 1.9 2 0 0 2 2 2 1 Exocyst complex component Sec5 Vps51 PF08700.11 EGD93175.1 - 4e-05 23.6 0.4 0.00016 21.7 0.4 2.1 1 0 0 1 1 1 1 Vps51/Vps67 GTP-bdg_M PF16360.5 EGD93175.1 - 0.0052 17.4 0.6 0.61 10.7 0.1 3.7 3 0 0 3 3 3 1 GTP-binding GTPase Middle Region RINT1_TIP1 PF04437.13 EGD93175.1 - 0.02 13.8 0.2 0.039 12.8 0.2 1.4 1 0 0 1 1 1 0 RINT-1 / TIP-1 family DUF802 PF05650.11 EGD93175.1 - 0.68 10.5 4.0 0.32 11.5 0.4 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF802) Mo-co_dimer PF03404.16 EGD93176.1 - 2e-58 196.3 0.5 3.5e-58 195.5 0.5 1.4 1 0 0 1 1 1 1 Mo-co oxidoreductase dimerisation domain Oxidored_molyb PF00174.19 EGD93176.1 - 5.6e-54 182.3 0.0 9.6e-54 181.6 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase molybdopterin binding domain NAD_binding_1 PF00175.21 EGD93176.1 - 1.6e-27 96.3 0.0 1e-26 93.7 0.0 2.2 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain Cyt-b5 PF00173.28 EGD93176.1 - 1.1e-18 67.1 0.0 2.5e-18 66.0 0.0 1.7 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain FAD_binding_6 PF00970.24 EGD93176.1 - 3.8e-17 62.5 0.0 6.7e-17 61.7 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 EGD93176.1 - 0.00052 20.2 0.1 0.0092 16.1 0.0 2.3 1 1 1 2 2 2 1 Ferric reductase NAD binding domain LPMO_10 PF03067.15 EGD93178.1 - 0.0063 17.2 0.2 0.024 15.3 0.2 1.8 1 1 0 1 1 1 1 Lytic polysaccharide mono-oxygenase, cellulose-degrading PI-PLC-X PF00388.19 EGD93182.1 - 4.8e-58 194.9 0.0 1e-57 193.8 0.0 1.6 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 EGD93182.1 - 2e-42 144.2 0.1 3.9e-42 143.2 0.1 1.5 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain C2 PF00168.30 EGD93182.1 - 9.8e-05 22.6 0.0 0.00066 19.9 0.0 2.3 1 1 0 1 1 1 1 C2 domain EF-hand_like PF09279.11 EGD93182.1 - 0.003 18.0 0.6 0.0087 16.5 0.6 1.8 1 1 0 1 1 1 1 Phosphoinositide-specific phospholipase C, efhand-like EF-hand_8 PF13833.6 EGD93182.1 - 0.0049 16.7 0.0 0.01 15.6 0.0 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_7 PF13499.6 EGD93182.1 - 0.13 12.8 0.0 0.51 10.8 0.0 2.0 2 0 0 2 2 2 0 EF-hand domain pair AhpC-TSA_2 PF13911.6 EGD93183.1 - 9.5e-12 45.0 0.0 1.5e-11 44.4 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA antioxidant enzyme AhpC-TSA PF00578.21 EGD93183.1 - 0.00087 19.2 0.0 0.0015 18.4 0.0 1.4 1 0 0 1 1 1 1 AhpC/TSA family Brix PF04427.18 EGD93184.1 - 4.7e-32 111.7 0.0 6e-32 111.3 0.0 1.1 1 0 0 1 1 1 1 Brix domain AAA_12 PF13087.6 EGD93185.1 - 4.6e-58 196.1 0.0 7.3e-58 195.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 EGD93185.1 - 4.5e-52 177.4 5.3 4.6e-30 105.3 0.3 2.3 1 1 1 2 2 2 2 AAA domain UPF1_Zn_bind PF09416.10 EGD93185.1 - 6.9e-48 162.5 0.8 3.2e-46 157.0 0.0 2.4 2 0 0 2 2 2 1 RNA helicase (UPF2 interacting domain) DUF5599 PF18141.1 EGD93185.1 - 3e-33 113.9 0.0 6.2e-33 112.9 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF5599) AAA_30 PF13604.6 EGD93185.1 - 3.7e-12 46.4 0.2 3e-11 43.4 0.2 2.2 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EGD93185.1 - 5.4e-10 39.8 0.1 2.6e-09 37.5 0.0 2.1 2 1 0 2 2 2 1 AAA domain ResIII PF04851.15 EGD93185.1 - 3.4e-06 27.2 0.0 6.6e-06 26.2 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_RecD PF05127.14 EGD93185.1 - 0.00017 21.5 0.0 0.00033 20.5 0.0 1.5 1 0 0 1 1 1 1 Helicase Viral_helicase1 PF01443.18 EGD93185.1 - 0.00046 20.0 0.1 1.2 8.8 0.0 2.8 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase DUF2075 PF09848.9 EGD93185.1 - 0.0019 17.5 0.6 0.033 13.4 0.1 2.4 2 1 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) UvrD-helicase PF00580.21 EGD93185.1 - 0.022 14.3 0.1 0.29 10.6 0.1 2.3 2 1 1 3 3 3 0 UvrD/REP helicase N-terminal domain PIF1 PF05970.14 EGD93185.1 - 0.024 13.8 0.0 5.7 6.0 0.0 2.2 2 0 0 2 2 2 0 PIF1-like helicase DEAD PF00270.29 EGD93185.1 - 0.025 14.3 0.3 0.05 13.4 0.2 1.6 1 1 0 1 1 1 0 DEAD/DEAH box helicase AAA_22 PF13401.6 EGD93185.1 - 0.028 14.7 0.0 0.082 13.2 0.0 1.8 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 EGD93185.1 - 0.044 13.2 0.0 0.099 12.1 0.0 1.6 1 0 0 1 1 1 0 PhoH-like protein DUF4123 PF13503.6 EGD93185.1 - 0.075 13.5 0.7 0.93 9.9 0.4 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4123) SRP54 PF00448.22 EGD93185.1 - 0.1 12.2 0.0 0.32 10.6 0.0 1.8 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_10 PF12846.7 EGD93185.1 - 0.14 11.1 0.0 0.22 10.4 0.0 1.2 1 0 0 1 1 1 0 AAA-like domain AAA_16 PF13191.6 EGD93185.1 - 0.14 12.5 0.1 0.29 11.5 0.1 1.4 1 0 0 1 1 1 0 AAA ATPase domain ATPase PF06745.13 EGD93185.1 - 0.2 10.9 0.0 0.38 10.1 0.0 1.5 1 0 0 1 1 1 0 KaiC TFIIF_alpha PF05793.12 EGD93185.1 - 0.55 8.8 3.2 0.93 8.0 3.2 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) PBP1_TM PF14812.6 EGD93185.1 - 1.2 9.6 4.7 3.1 8.2 4.7 1.6 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal PTCB-BRCT PF12738.7 EGD93186.1 - 5.9e-07 29.3 0.1 1.2e-06 28.3 0.1 1.6 1 0 0 1 1 1 1 twin BRCT domain BRCT_2 PF16589.5 EGD93186.1 - 7e-06 26.4 0.0 1.5e-05 25.3 0.0 1.5 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 EGD93186.1 - 1.5e-05 25.3 0.0 3.5e-05 24.1 0.0 1.7 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain WGR PF05406.15 EGD93186.1 - 0.0002 21.3 0.0 0.00044 20.2 0.0 1.5 1 0 0 1 1 1 1 WGR domain IGPS PF00218.21 EGD93187.1 - 2e-94 315.5 0.0 4.6e-94 314.3 0.0 1.6 2 0 0 2 2 2 1 Indole-3-glycerol phosphate synthase PRAI PF00697.22 EGD93187.1 - 8.6e-52 175.7 0.1 8.4e-47 159.5 0.0 2.3 2 0 0 2 2 2 2 N-(5'phosphoribosyl)anthranilate (PRA) isomerase GATase PF00117.28 EGD93187.1 - 7e-48 162.9 0.0 1.4e-47 162.0 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 EGD93187.1 - 0.00095 19.0 1.2 0.0049 16.6 0.6 2.2 2 1 0 2 2 2 1 Peptidase C26 QRPTase_C PF01729.19 EGD93187.1 - 0.016 15.0 0.3 0.91 9.3 0.0 2.5 2 0 0 2 2 2 0 Quinolinate phosphoribosyl transferase, C-terminal domain His_biosynth PF00977.21 EGD93187.1 - 0.018 14.5 0.1 0.12 11.8 0.0 2.1 2 0 0 2 2 2 0 Histidine biosynthesis protein NanE PF04131.14 EGD93187.1 - 0.14 11.3 0.4 0.41 9.8 0.0 2.0 3 0 0 3 3 3 0 Putative N-acetylmannosamine-6-phosphate epimerase Nup188_C PF18378.1 EGD93188.1 - 2.9e-138 460.7 0.0 4.7e-138 460.0 0.0 1.3 1 0 0 1 1 1 1 Nuclear pore protein NUP188 C-terminal domain Nup188 PF10487.9 EGD93188.1 - 2.6e-81 273.9 0.1 6.1e-68 229.7 0.0 2.7 2 1 0 2 2 2 2 Nucleoporin subcomplex protein binding to Pom34 AMP-binding PF00501.28 EGD93189.1 - 2.8e-68 230.5 0.0 6.5e-49 166.7 0.0 2.1 2 0 0 2 2 2 2 AMP-binding enzyme AMP-binding_C PF13193.6 EGD93189.1 - 3.6e-13 50.3 0.3 1.3e-11 45.3 0.3 2.7 1 1 0 1 1 1 1 AMP-binding enzyme C-terminal domain Acetyltransf_1 PF00583.25 EGD93192.1 - 0.00032 20.9 0.0 0.00088 19.5 0.0 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EGD93192.1 - 0.00044 20.2 0.0 0.016 15.1 0.0 2.2 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EGD93192.1 - 0.071 13.5 0.0 0.14 12.6 0.0 1.7 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Use1 PF09753.9 EGD93193.1 - 5.1e-11 42.8 13.7 7.2e-09 35.7 13.7 2.2 1 1 0 1 1 1 1 Membrane fusion protein Use1 Hamartin PF04388.12 EGD93193.1 - 0.45 9.1 23.2 0.77 8.3 23.2 1.4 1 0 0 1 1 1 0 Hamartin protein DUF5538 PF17692.1 EGD93193.1 - 0.59 10.2 4.4 1.4 9.0 4.4 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5538) DUF4482 PF14818.6 EGD93193.1 - 1 10.2 6.2 0.27 12.1 1.9 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4482) HR1 PF02185.16 EGD93193.1 - 3.4 7.9 10.5 0.17 12.0 3.6 2.5 2 1 0 2 2 2 0 Hr1 repeat Macoilin PF09726.9 EGD93193.1 - 4.7 5.6 15.8 10 4.5 15.3 1.6 1 1 1 2 2 2 0 Macoilin family DUF4683 PF15735.5 EGD93193.1 - 5.3 6.5 11.7 0.32 10.6 6.6 1.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4683) Menin PF05053.13 EGD93193.1 - 8.3 4.6 9.7 12 4.1 9.7 1.2 1 0 0 1 1 1 0 Menin G-alpha PF00503.20 EGD93194.1 - 1.4e-108 363.3 4.1 2.1e-95 319.9 0.3 2.0 1 1 1 2 2 2 2 G-protein alpha subunit Arf PF00025.21 EGD93194.1 - 5.3e-13 48.8 1.0 2.2e-10 40.2 0.1 2.4 2 0 0 2 2 2 2 ADP-ribosylation factor family zf-CHC2 PF01807.20 EGD93194.1 - 5.7e-05 22.8 0.0 0.00024 20.8 0.0 1.9 2 0 0 2 2 2 1 CHC2 zinc finger CH PF00307.31 EGD93196.1 - 2.5e-48 162.8 0.2 8.9e-24 83.8 0.0 3.0 3 0 0 3 3 3 2 Calponin homology (CH) domain EFhand_Ca_insen PF08726.10 EGD93196.1 - 2.2e-25 88.5 0.2 5.5e-25 87.2 0.2 1.8 1 0 0 1 1 1 1 Ca2+ insensitive EF hand CAMSAP_CH PF11971.8 EGD93196.1 - 1.2e-10 41.1 0.1 3.7e-07 29.9 0.0 2.9 2 0 0 2 2 2 2 CAMSAP CH domain EF-hand_6 PF13405.6 EGD93196.1 - 0.0013 18.5 0.0 0.0077 16.1 0.0 2.4 1 0 0 1 1 1 1 EF-hand domain CH_2 PF06294.11 EGD93196.1 - 0.0031 17.6 0.0 0.2 11.8 0.0 2.8 2 0 0 2 2 2 1 CH-like domain in sperm protein EF-hand_8 PF13833.6 EGD93196.1 - 0.0067 16.3 0.2 0.045 13.6 0.1 2.5 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.32 EGD93196.1 - 0.017 14.6 0.0 0.23 11.1 0.0 2.7 2 0 0 2 2 2 0 EF hand SKA1 PF07160.12 EGD93196.1 - 0.093 12.6 1.5 0.19 11.5 0.9 1.8 1 1 0 1 1 1 0 Spindle and kinetochore-associated protein 1 FliG_N PF14842.6 EGD93196.1 - 0.17 12.4 2.6 3.8 8.1 0.1 3.1 2 1 1 3 3 3 0 FliG N-terminal domain zf-RRPl_C4 PF17026.5 EGD93196.1 - 0.17 12.0 0.0 0.49 10.5 0.0 1.8 1 0 0 1 1 1 0 Putative ribonucleoprotein zinc-finger pf C4 type EF-hand_7 PF13499.6 EGD93196.1 - 0.23 11.9 2.5 0.93 10.0 0.2 2.9 2 0 0 2 2 2 0 EF-hand domain pair Spectrin PF00435.21 EGD93196.1 - 0.25 11.9 10.4 0.71 10.4 0.0 3.2 3 1 0 3 3 3 0 Spectrin repeat SAPS PF04499.15 EGD93197.1 - 7.2 5.3 7.9 8.9 5.0 7.9 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Dickkopf_N PF04706.12 EGD93199.1 - 0.00091 19.7 12.3 0.00091 19.7 12.3 4.5 4 0 0 4 4 4 2 Dickkopf N-terminal cysteine-rich region EB PF01683.18 EGD93199.1 - 0.051 13.9 4.7 0.051 13.9 4.7 5.1 1 1 2 4 4 4 0 EB module YbgS PF13985.6 EGD93199.1 - 0.47 10.8 6.3 0.34 11.2 0.7 2.5 2 1 0 2 2 2 0 YbgS-like protein Ribosomal_S16 PF00886.19 EGD93200.1 - 1.9e-24 85.4 0.1 3.1e-24 84.8 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein S16 YjeF_N PF03853.15 EGD93201.1 - 9.2e-37 126.6 0.0 1.1e-36 126.3 0.0 1.1 1 0 0 1 1 1 1 YjeF-related protein N-terminus SL4P PF17618.2 EGD93201.1 - 0.22 11.6 0.0 0.41 10.7 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized Strongylid L4 protein PUL PF08324.11 EGD93202.1 - 2.6e-71 240.1 0.2 3.4e-71 239.7 0.2 1.2 1 0 0 1 1 1 1 PUL domain WD40 PF00400.32 EGD93202.1 - 4e-30 103.4 16.8 6.2e-07 30.0 0.0 7.9 8 0 0 8 8 8 6 WD domain, G-beta repeat PFU PF09070.11 EGD93202.1 - 3.3e-29 101.4 0.2 7.7e-29 100.2 0.2 1.6 1 0 0 1 1 1 1 PFU (PLAA family ubiquitin binding) WD40 PF00400.32 EGD93203.1 - 1.4e-08 35.2 1.8 1.4e-06 28.9 0.1 3.1 3 0 0 3 3 3 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EGD93203.1 - 0.024 14.9 0.0 0.06 13.7 0.0 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EGD93203.1 - 0.029 13.4 0.0 0.39 9.6 0.0 2.0 2 0 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein RRM_1 PF00076.22 EGD93204.1 - 2.1e-16 59.5 0.0 3.6e-16 58.7 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FoP_duplication PF13865.6 EGD93204.1 - 4.9e-07 30.2 9.4 4.9e-07 30.2 9.4 4.1 4 0 0 4 4 4 2 C-terminal duplication domain of Friend of PRMT1 Bot1p PF12298.8 EGD93205.1 - 1.3e-58 198.0 0.8 1.3e-58 198.0 0.8 1.8 2 0 0 2 2 2 1 Eukaryotic mitochondrial regulator protein Pkinase PF00069.25 EGD93207.1 - 5.9e-51 173.3 0.0 8.1e-51 172.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD93207.1 - 5.8e-25 88.0 0.2 3.2e-24 85.6 0.2 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EGD93207.1 - 0.002 17.5 0.0 0.0044 16.4 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EGD93207.1 - 0.086 11.6 0.0 0.19 10.4 0.0 1.6 1 0 0 1 1 1 0 Fungal protein kinase Kdo PF06293.14 EGD93207.1 - 0.2 11.0 0.0 0.36 10.1 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RNA_pol_3_Rpc31 PF11705.8 EGD93208.1 - 0.075 13.3 12.2 0.091 13.0 12.2 1.0 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 Myc_N PF01056.18 EGD93208.1 - 0.22 11.4 5.6 0.23 11.3 5.6 1.2 1 0 0 1 1 1 0 Myc amino-terminal region Astro_capsid_p PF12226.8 EGD93208.1 - 6.4 5.8 8.5 6.5 5.8 8.5 1.1 1 0 0 1 1 1 0 Turkey astrovirus capsid protein RRP14 PF15459.6 EGD93209.1 - 4.5 7.9 15.1 6.5 7.4 15.1 1.2 1 0 0 1 1 1 0 60S ribosome biogenesis protein Rrp14 BSP_II PF05432.11 EGD93210.1 - 0.0013 18.5 3.8 0.0015 18.3 3.8 1.0 1 0 0 1 1 1 1 Bone sialoprotein II (BSP-II) RNA_pol_3_Rpc31 PF11705.8 EGD93210.1 - 0.0033 17.7 4.5 0.0034 17.7 4.5 1.1 1 0 0 1 1 1 1 DNA-directed RNA polymerase III subunit Rpc31 NOA36 PF06524.12 EGD93210.1 - 0.0036 16.7 6.9 0.0038 16.6 6.9 1.1 1 0 0 1 1 1 1 NOA36 protein SDA1 PF05285.12 EGD93210.1 - 0.012 15.1 7.0 0.014 14.9 7.0 1.0 1 0 0 1 1 1 0 SDA1 RXT2_N PF08595.11 EGD93210.1 - 0.038 14.0 2.6 0.041 13.9 2.6 1.2 1 0 0 1 1 1 0 RXT2-like, N-terminal PPP4R2 PF09184.11 EGD93210.1 - 0.066 12.8 4.4 0.067 12.8 4.4 1.1 1 0 0 1 1 1 0 PPP4R2 Nop14 PF04147.12 EGD93210.1 - 0.12 10.6 5.6 0.11 10.7 5.6 1.0 1 0 0 1 1 1 0 Nop14-like family FAM176 PF14851.6 EGD93210.1 - 0.2 11.3 6.8 0.29 10.8 6.8 1.2 1 0 0 1 1 1 0 FAM176 family GCIP PF13324.6 EGD93210.1 - 0.37 10.4 3.0 0.38 10.3 3.0 1.1 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting Nucleo_P87 PF07267.11 EGD93210.1 - 0.39 9.5 2.6 0.38 9.5 2.6 1.0 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 DUF4611 PF15387.6 EGD93210.1 - 0.64 10.3 9.6 1.2 9.4 9.6 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) TFB6 PF17110.5 EGD93210.1 - 1.2 8.9 4.5 1.7 8.3 4.5 1.2 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH PBP1_TM PF14812.6 EGD93210.1 - 2.5 8.5 14.6 0.59 10.5 11.7 1.4 2 0 0 2 2 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF2722 PF10846.8 EGD93210.1 - 4 6.3 5.6 4.8 6.0 5.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Pox_Ag35 PF03286.14 EGD93210.1 - 4.7 7.0 8.5 6.3 6.5 8.5 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Radial_spoke PF04712.12 EGD93210.1 - 8.2 5.2 8.7 10 4.9 8.7 1.1 1 0 0 1 1 1 0 Radial spokehead-like protein CDC45 PF02724.14 EGD93210.1 - 8.5 4.5 9.4 11 4.2 9.4 1.1 1 0 0 1 1 1 0 CDC45-like protein AMP-binding PF00501.28 EGD93212.1 - 7.9e-97 324.5 0.0 9.2e-97 324.3 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EGD93212.1 - 2.2e-13 51.0 0.3 6.8e-13 49.4 0.3 1.9 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain SET PF00856.28 EGD93213.1 - 1.6e-11 44.9 0.0 2.1e-11 44.5 0.0 1.3 1 0 0 1 1 1 1 SET domain UBA_4 PF14555.6 EGD93214.1 - 1.1e-12 47.6 0.4 2.2e-12 46.6 0.4 1.5 1 0 0 1 1 1 1 UBA-like domain Mst1_SARAH PF11629.8 EGD93214.1 - 2.4 8.3 4.1 56 3.9 0.0 3.4 3 0 0 3 3 3 0 C terminal SARAH domain of Mst1 Dynactin_p22 PF07426.11 EGD93215.1 - 5.4e-07 29.6 0.0 7.9e-07 29.1 0.0 1.2 1 0 0 1 1 1 1 Dynactin subunit p22 SH3_1 PF00018.28 EGD93216.1 - 3e-09 36.4 0.1 5.2e-09 35.6 0.1 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EGD93216.1 - 3.6e-07 29.9 0.0 1e-06 28.5 0.0 1.8 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.17 EGD93216.1 - 6.7e-06 25.7 0.0 1.3e-05 24.8 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_10 PF17902.1 EGD93216.1 - 0.09 12.9 0.0 0.16 12.0 0.0 1.3 1 0 0 1 1 1 0 SH3 domain YhhN PF07947.14 EGD93216.1 - 0.14 11.7 8.7 0.2 11.3 8.7 1.1 1 0 0 1 1 1 0 YhhN family Response_reg PF00072.24 EGD93217.1 - 3.6e-21 75.4 0.0 2.5e-14 53.4 0.0 2.3 2 0 0 2 2 2 2 Response regulator receiver domain DUF2052 PF09747.9 EGD93218.1 - 6.2e-20 72.2 16.5 4.1e-10 40.1 0.4 2.1 1 1 1 2 2 2 2 Coiled-coil domain containing protein (DUF2052) Spermine_synth PF01564.17 EGD93219.1 - 1.1e-05 24.9 0.2 2.1e-05 24.0 0.2 1.3 1 0 0 1 1 1 1 Spermine/spermidine synthase domain Methyltransf_23 PF13489.6 EGD93219.1 - 0.02 14.8 0.0 0.032 14.1 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_30 PF05430.11 EGD93219.1 - 0.042 13.7 0.0 0.079 12.9 0.0 1.4 1 0 0 1 1 1 0 S-adenosyl-L-methionine-dependent methyltransferase Y_phosphatase3 PF13350.6 EGD93220.1 - 1.1e-57 195.7 0.0 1.3e-57 195.5 0.0 1.0 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase2 PF03162.13 EGD93220.1 - 0.0064 16.1 0.0 0.0099 15.5 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family Lysis_col PF02402.16 EGD93220.1 - 0.02 14.6 0.1 0.042 13.5 0.1 1.5 1 0 0 1 1 1 0 Lysis protein Y_phosphatase PF00102.27 EGD93220.1 - 0.034 13.7 0.0 0.048 13.2 0.0 1.2 1 0 0 1 1 1 0 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 EGD93220.1 - 0.21 11.7 0.0 0.35 11.0 0.0 1.3 1 0 0 1 1 1 0 Inositol hexakisphosphate Peptidase_C12 PF01088.21 EGD93221.1 - 3.2e-51 174.1 0.0 3.8e-51 173.8 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 Peptidase_S9 PF00326.21 EGD93223.1 - 3e-50 170.6 0.2 8.4e-50 169.2 0.1 1.7 2 0 0 2 2 2 1 Prolyl oligopeptidase family PD40 PF07676.12 EGD93223.1 - 6.6e-11 41.9 1.4 0.0056 16.6 0.0 4.9 4 0 0 4 4 4 4 WD40-like Beta Propeller Repeat Peptidase_S9_N PF02897.15 EGD93223.1 - 0.02 13.7 0.0 0.05 12.4 0.0 1.6 2 0 0 2 2 2 0 Prolyl oligopeptidase, N-terminal beta-propeller domain DLIC PF05783.11 EGD93224.1 - 5.5e-31 107.9 2.1 5.6e-27 94.7 0.0 3.9 2 1 0 3 3 3 3 Dynein light intermediate chain (DLIC) Urb2 PF10441.9 EGD93224.1 - 0.2 11.6 0.0 4.2 7.3 0.0 2.1 2 0 0 2 2 2 0 Urb2/Npa2 family RRM_1 PF00076.22 EGD93225.1 - 1.2e-19 69.9 0.1 4.6e-19 68.0 0.0 2.0 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EGD93225.1 - 1.4e-05 25.2 0.0 4.6e-05 23.5 0.0 1.9 1 1 0 1 1 1 1 RNA recognition motif RRM_5 PF13893.6 EGD93225.1 - 0.14 11.7 0.0 0.26 10.9 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) OB_RNB PF08206.11 EGD93225.1 - 1.6 8.5 0.0 1.6 8.5 0.0 3.1 3 1 0 3 3 3 0 Ribonuclease B OB domain WD40 PF00400.32 EGD93226.1 - 0.00012 22.8 0.0 0.93 10.5 0.0 3.1 3 0 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EGD93226.1 - 0.0011 19.2 0.0 0.43 10.9 0.0 2.6 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EGD93226.1 - 0.021 13.8 0.1 0.14 11.1 0.1 2.0 1 1 1 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Nbas_N PF15492.6 EGD93226.1 - 0.047 13.0 0.0 0.29 10.4 0.0 1.9 1 1 1 2 2 2 0 Neuroblastoma-amplified sequence, N terminal Septin PF00735.18 EGD93227.1 - 3.9e-108 361.0 0.3 6.3e-108 360.3 0.0 1.4 2 0 0 2 2 2 1 Septin MMR_HSR1 PF01926.23 EGD93227.1 - 9.7e-06 25.7 0.0 2.4e-05 24.4 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 EGD93227.1 - 0.0011 19.0 4.0 1 9.4 0.0 3.2 2 1 1 3 3 3 2 Dynamin family GTP_EFTU PF00009.27 EGD93227.1 - 0.0029 17.2 0.2 0.17 11.4 0.0 2.3 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EGD93227.1 - 0.0079 16.1 0.5 0.0079 16.1 0.5 2.5 3 1 0 3 3 3 1 RsgA GTPase AIG1 PF04548.16 EGD93227.1 - 0.016 14.5 0.0 0.04 13.2 0.0 1.7 1 0 0 1 1 1 0 AIG1 family IIGP PF05049.13 EGD93227.1 - 0.062 12.3 0.0 0.11 11.5 0.0 1.4 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) ABC_tran PF00005.27 EGD93227.1 - 0.18 12.3 1.3 0.96 10.0 0.0 2.5 2 1 0 2 2 2 0 ABC transporter EB1 PF03271.17 EGD93227.1 - 0.33 11.2 4.3 3.5 8.0 1.3 2.8 2 0 0 2 2 2 0 EB1-like C-terminal motif CNH PF00780.22 EGD93228.1 - 2.9e-81 273.1 0.0 2e-80 270.4 0.0 2.0 2 0 0 2 2 2 1 CNH domain PH_5 PF15405.6 EGD93228.1 - 1.5e-39 135.2 0.0 3.3e-39 134.1 0.0 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain RhoGEF PF00621.20 EGD93228.1 - 8.8e-38 130.4 0.0 1.6e-37 129.5 0.0 1.5 1 0 0 1 1 1 1 RhoGEF domain DEP PF00610.21 EGD93228.1 - 3.9e-13 49.3 0.0 8.4e-13 48.2 0.0 1.6 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) ATP-synt_C PF00137.21 EGD93229.1 - 8.4e-29 99.7 36.0 6.5e-18 64.8 14.4 2.2 2 0 0 2 2 2 2 ATP synthase subunit C Pkinase PF00069.25 EGD93230.1 - 1.6e-63 214.6 0.0 2.3e-63 214.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD93230.1 - 4.4e-34 117.9 0.0 6.1e-34 117.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EGD93230.1 - 0.0005 19.5 0.0 0.00077 18.9 0.0 1.3 1 0 0 1 1 1 1 Kinase-like PyrBI_leader PF08052.11 EGD93230.1 - 0.0082 16.1 0.1 2.8 8.0 0.0 2.5 2 0 0 2 2 2 2 PyrBI operon leader peptide Haspin_kinase PF12330.8 EGD93230.1 - 0.012 14.5 0.0 0.017 14.1 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain DUF2773 PF10971.8 EGD93230.1 - 0.032 14.4 0.1 0.099 12.8 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2773) APH PF01636.23 EGD93230.1 - 0.037 14.0 0.0 0.13 12.1 0.0 1.8 1 1 1 2 2 2 0 Phosphotransferase enzyme family Choline_kinase PF01633.20 EGD93230.1 - 0.094 12.3 0.0 0.16 11.5 0.0 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase Kdo PF06293.14 EGD93230.1 - 0.099 12.0 0.0 0.18 11.1 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.11 EGD93230.1 - 0.23 10.5 0.0 0.36 9.9 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Gly_transf_sug PF04488.15 EGD93231.1 - 1.6e-14 54.3 0.0 3e-14 53.4 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif Trypan_PARP PF05887.11 EGD93231.1 - 0.0024 17.9 8.9 0.0039 17.2 8.9 1.3 1 0 0 1 1 1 1 Procyclic acidic repetitive protein (PARP) Abhydrolase_1 PF00561.20 EGD93233.1 - 8.2e-33 114.1 0.5 1.1e-32 113.7 0.2 1.4 2 0 0 2 2 2 1 alpha/beta hydrolase fold Esterase PF00756.20 EGD93233.1 - 0.00031 20.5 0.0 0.00052 19.7 0.0 1.3 1 0 0 1 1 1 1 Putative esterase EphA2_TM PF14575.6 EGD93234.1 - 0.18 12.7 0.0 0.44 11.5 0.0 1.6 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain GSHPx PF00255.19 EGD93236.1 - 1.7e-39 133.7 0.0 2.3e-39 133.3 0.0 1.2 1 0 0 1 1 1 1 Glutathione peroxidase AhpC-TSA PF00578.21 EGD93236.1 - 0.04 13.8 0.0 0.12 12.3 0.0 1.9 1 1 0 1 1 1 0 AhpC/TSA family Ral PF11058.8 EGD93236.1 - 0.12 12.0 0.1 0.22 11.1 0.1 1.4 1 0 0 1 1 1 0 Antirestriction protein Ral ORC6 PF05460.13 EGD93237.1 - 0.24 10.6 8.1 0.28 10.4 8.1 1.1 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) Hydrolase_6 PF13344.6 EGD93238.1 - 6.5e-24 84.0 0.0 1.4e-23 82.9 0.0 1.6 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EGD93238.1 - 5.5e-11 42.4 0.0 2.5e-10 40.2 0.0 2.2 2 0 0 2 2 2 1 HAD-hyrolase-like Hydrolase PF00702.26 EGD93238.1 - 0.095 13.0 0.0 22 5.3 0.0 2.8 3 0 0 3 3 3 0 haloacid dehalogenase-like hydrolase DUF676 PF05057.14 EGD93239.1 - 3.9e-48 163.8 0.0 5.9e-48 163.3 0.0 1.2 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Palm_thioest PF02089.15 EGD93239.1 - 0.00012 22.1 0.0 0.0002 21.3 0.0 1.4 1 0 0 1 1 1 1 Palmitoyl protein thioesterase Lipase_3 PF01764.25 EGD93239.1 - 0.00042 20.2 0.0 0.00084 19.2 0.0 1.4 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_6 PF12697.7 EGD93239.1 - 0.0011 19.6 0.0 0.0017 19.0 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family PE-PPE PF08237.11 EGD93239.1 - 0.012 15.1 0.0 0.025 14.1 0.0 1.4 1 0 0 1 1 1 0 PE-PPE domain PGAP1 PF07819.13 EGD93239.1 - 0.013 15.2 0.0 0.049 13.4 0.0 1.9 2 1 0 2 2 2 0 PGAP1-like protein DUF915 PF06028.11 EGD93239.1 - 0.03 13.7 0.0 7.9 5.7 0.1 2.2 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF915) Ribosomal_L22e PF01776.17 EGD93241.1 - 6.5e-47 158.4 0.5 8.1e-47 158.1 0.5 1.0 1 0 0 1 1 1 1 Ribosomal L22e protein family Translin PF01997.16 EGD93242.1 - 3.2e-54 184.0 0.0 3.7e-54 183.8 0.0 1.0 1 0 0 1 1 1 1 Translin family Rx_N PF18052.1 EGD93242.1 - 0.004 17.4 1.1 0.89 9.9 0.6 3.3 2 1 0 2 2 2 1 Rx N-terminal domain Syntaxin_2 PF14523.6 EGD93242.1 - 0.1 13.0 1.8 0.29 11.5 0.4 2.4 3 1 0 3 3 3 0 Syntaxin-like protein Pcc1 PF09341.10 EGD93243.1 - 1.4e-33 114.8 2.6 1.8e-33 114.5 2.6 1.1 1 0 0 1 1 1 1 Transcription factor Pcc1 DSPn PF14671.6 EGD93245.1 - 2.7e-39 134.8 0.0 2e-37 128.8 0.0 2.7 2 1 0 2 2 2 1 Dual specificity protein phosphatase, N-terminal half DSPc PF00782.20 EGD93245.1 - 8.5e-16 58.0 0.0 1.8e-15 56.9 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EGD93245.1 - 6.6e-05 22.6 0.0 0.00011 21.9 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Pyridoxal_deC PF00282.19 EGD93247.1 - 5e-30 104.5 0.0 6.7e-30 104.0 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Pyridoxal_deC PF00282.19 EGD93248.1 - 7.5e-10 38.1 0.0 9e-10 37.8 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain SnoaL_4 PF13577.6 EGD93248.1 - 0.11 12.6 0.0 0.21 11.7 0.0 1.5 1 1 0 1 1 1 0 SnoaL-like domain DUF917 PF06032.12 EGD93249.1 - 1.9e-73 247.3 0.8 4.6e-36 124.4 0.0 3.0 3 0 0 3 3 3 2 Protein of unknown function (DUF917) Hydantoinase_A PF01968.18 EGD93249.1 - 1.9e-31 109.5 7.4 1.8e-26 93.1 0.9 3.3 2 1 1 3 3 3 3 Hydantoinase/oxoprolinase Hydant_A_N PF05378.13 EGD93249.1 - 3.6e-27 95.2 1.8 9e-25 87.4 0.1 2.8 2 0 0 2 2 2 2 Hydantoinase/oxoprolinase N-terminal region MutL PF13941.6 EGD93249.1 - 0.00022 20.0 5.4 0.024 13.3 0.5 2.6 3 0 0 3 3 3 2 MutL protein BcrAD_BadFG PF01869.20 EGD93249.1 - 0.03 13.8 0.3 0.03 13.8 0.3 2.9 2 1 0 2 2 2 0 BadF/BadG/BcrA/BcrD ATPase family Cucumo_coat PF00760.18 EGD93249.1 - 0.044 13.4 0.0 0.13 11.9 0.0 1.7 2 0 0 2 2 2 0 Cucumovirus coat protein BRE PF06113.12 EGD93249.1 - 0.074 11.9 0.0 0.13 11.1 0.0 1.3 1 0 0 1 1 1 0 Brain and reproductive organ-expressed protein (BRE) FtsA PF14450.6 EGD93249.1 - 0.2 12.1 7.0 6.7 7.2 0.3 3.5 3 2 0 3 3 3 0 Cell division protein FtsA Homeodomain PF00046.29 EGD93250.1 - 5.5e-14 51.8 1.2 1.4e-13 50.4 1.2 1.8 1 0 0 1 1 1 1 Homeodomain REV PF00424.18 EGD93250.1 - 1.8 8.6 7.0 0.19 11.8 0.2 2.8 3 0 0 3 3 3 0 REV protein (anti-repression trans-activator protein) MFS_1 PF07690.16 EGD93251.1 - 4.4e-41 141.0 10.9 1e-33 116.8 12.7 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 EGD93251.1 - 2.9e-11 42.4 7.5 3.9e-11 42.0 3.2 2.7 1 1 1 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family Sugar_tr PF00083.24 EGD93251.1 - 6.3e-10 38.5 9.6 1.6e-07 30.5 3.9 2.4 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_4 PF06779.14 EGD93251.1 - 5.4e-06 26.0 3.0 0.003 16.9 0.1 2.5 2 0 0 2 2 2 2 Uncharacterised MFS-type transporter YbfB MFS_3 PF05977.13 EGD93251.1 - 0.00053 18.5 2.5 0.013 13.9 2.0 2.7 2 1 1 3 3 3 2 Transmembrane secretion effector MFS_2 PF13347.6 EGD93251.1 - 0.00056 18.6 16.3 0.005 15.5 8.1 3.0 3 1 0 3 3 3 2 MFS/sugar transport protein MscS_TM PF12794.7 EGD93251.1 - 0.0099 14.8 0.4 0.027 13.3 0.1 2.0 2 1 0 2 2 2 1 Mechanosensitive ion channel inner membrane domain 1 Fungal_trans_2 PF11951.8 EGD93252.1 - 1.7e-52 178.5 0.1 2.4e-52 178.1 0.1 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EGD93252.1 - 1.2e-07 31.8 9.8 1.2e-07 31.8 9.8 1.8 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Pkinase PF00069.25 EGD93253.1 - 7.8e-61 205.7 0.0 3.8e-60 203.5 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD93253.1 - 4.8e-29 101.4 0.5 3.9e-20 72.2 0.1 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase_C PF00433.24 EGD93253.1 - 0.00029 21.5 1.0 0.00082 20.0 1.0 1.8 1 0 0 1 1 1 1 Protein kinase C terminal domain APH PF01636.23 EGD93253.1 - 0.00029 20.8 2.4 0.48 10.3 0.0 3.5 2 1 1 3 3 3 2 Phosphotransferase enzyme family Kinase-like PF14531.6 EGD93253.1 - 0.00033 20.1 0.5 0.0016 17.9 0.0 2.2 3 0 0 3 3 3 1 Kinase-like Haspin_kinase PF12330.8 EGD93253.1 - 0.023 13.6 0.0 0.06 12.3 0.0 1.4 1 1 0 1 1 1 0 Haspin like kinase domain Kdo PF06293.14 EGD93253.1 - 0.032 13.6 0.1 0.091 12.1 0.0 1.7 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF1687 PF07955.11 EGD93254.1 - 3e-26 92.4 0.0 4e-26 92.0 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1687) 1-cysPrx_C PF10417.9 EGD93254.1 - 0.061 13.2 0.0 8.8 6.3 0.0 2.5 2 0 0 2 2 2 0 C-terminal domain of 1-Cys peroxiredoxin Abhydrolase_2 PF02230.16 EGD93255.1 - 6.1e-56 189.6 0.0 7.1e-56 189.4 0.0 1.0 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Peptidase_S9 PF00326.21 EGD93255.1 - 8.8e-08 31.9 0.1 1.9e-05 24.2 0.0 2.8 3 0 0 3 3 3 1 Prolyl oligopeptidase family DLH PF01738.18 EGD93255.1 - 3.6e-06 26.7 0.0 5.5e-06 26.1 0.0 1.2 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_3 PF07859.13 EGD93255.1 - 6.6e-05 22.9 0.0 0.024 14.5 0.0 2.2 1 1 0 2 2 2 2 alpha/beta hydrolase fold FSH1 PF03959.13 EGD93255.1 - 9.6e-05 22.1 0.0 0.00031 20.5 0.0 1.7 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Hydrolase_4 PF12146.8 EGD93255.1 - 0.00051 19.4 0.9 0.11 11.7 0.0 3.0 2 1 1 3 3 3 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EGD93255.1 - 0.0045 17.6 0.0 0.079 13.6 0.0 2.0 1 1 1 2 2 2 1 Alpha/beta hydrolase family Esterase PF00756.20 EGD93255.1 - 0.046 13.4 0.0 0.071 12.8 0.0 1.2 1 0 0 1 1 1 0 Putative esterase Lipase_3 PF01764.25 EGD93255.1 - 0.13 12.1 0.0 0.21 11.5 0.0 1.5 1 1 0 1 1 1 0 Lipase (class 3) Ctr PF04145.15 EGD93257.1 - 2e-27 96.6 0.0 2.4e-27 96.3 0.0 1.1 1 0 0 1 1 1 1 Ctr copper transporter family FAD_binding_8 PF08022.12 EGD93258.1 - 3.4e-20 72.1 0.0 8.2e-20 70.9 0.0 1.6 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_6 PF08030.12 EGD93258.1 - 4.7e-18 65.8 0.0 1.9e-17 63.8 0.0 1.9 2 0 0 2 2 2 1 Ferric reductase NAD binding domain Ferric_reduct PF01794.19 EGD93258.1 - 9.1e-18 64.6 11.5 2.3e-17 63.3 11.5 1.7 1 0 0 1 1 1 1 Ferric reductase like transmembrane component FAD_binding_3 PF01494.19 EGD93259.1 - 1.1e-70 238.6 0.2 1.4e-68 231.8 0.2 2.1 1 1 0 1 1 1 1 FAD binding domain Phe_hydrox_dim PF07976.12 EGD93259.1 - 4.6e-31 108.1 0.0 1.2e-30 106.7 0.0 1.7 2 0 0 2 2 2 1 Phenol hydroxylase, C-terminal dimerisation domain SE PF08491.10 EGD93259.1 - 0.014 14.5 0.0 0.046 12.8 0.0 1.7 2 0 0 2 2 2 0 Squalene epoxidase Trp_halogenase PF04820.14 EGD93259.1 - 0.083 11.7 0.1 0.16 10.8 0.0 1.4 2 0 0 2 2 2 0 Tryptophan halogenase Nup35_RRM PF05172.13 EGD93260.1 - 0.0015 18.5 0.0 0.0027 17.6 0.0 1.3 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif DUF1664 PF07889.12 EGD93261.1 - 0.012 15.6 0.2 0.018 15.0 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) DUF5024 PF16427.5 EGD93261.1 - 0.077 13.3 0.4 3 8.2 0.1 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF5024) BLOC1_2 PF10046.9 EGD93261.1 - 0.078 13.3 0.1 0.21 11.9 0.1 1.7 1 1 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Hrs_helical PF12210.8 EGD93261.1 - 0.14 12.7 2.2 12 6.6 0.2 2.4 2 0 0 2 2 2 0 Hepatocyte growth factor-regulated tyrosine kinase substrate Wbp11 PF09429.10 EGD93263.1 - 2.1e-20 72.9 17.2 2.1e-20 72.9 17.2 2.1 3 0 0 3 3 3 1 WW domain binding protein 11 Nkap_C PF06047.11 EGD93263.1 - 0.056 13.6 0.1 0.056 13.6 0.1 2.5 2 1 1 3 3 3 0 NF-kappa-B-activating protein C-terminal domain Pkinase PF00069.25 EGD93265.1 - 4e-55 187.0 0.0 1.1e-33 116.7 0.0 2.5 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EGD93265.1 - 7.9e-36 123.7 0.0 7.5e-35 120.4 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EGD93265.1 - 0.0057 15.5 0.4 0.071 11.9 0.0 2.2 2 0 0 2 2 2 1 Fungal protein kinase Spore_GerAC PF05504.11 EGD93265.1 - 0.23 11.7 2.6 0.54 10.5 2.6 1.6 1 0 0 1 1 1 0 Spore germination B3/ GerAC like, C-terminal DUF3896 PF13035.6 EGD93265.1 - 3 8.1 7.1 0.32 11.2 0.7 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF3896) ALMT PF11744.8 EGD93265.1 - 3.6 6.3 5.9 5.7 5.7 5.9 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter BTB PF00651.31 EGD93266.1 - 1.6e-26 92.7 0.0 3.8e-13 49.6 0.3 2.7 2 0 0 2 2 2 2 BTB/POZ domain Ank_2 PF12796.7 EGD93266.1 - 8.3e-07 29.5 0.1 1.6e-06 28.6 0.1 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EGD93266.1 - 3e-05 24.5 0.0 7.9e-05 23.1 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_5 PF13857.6 EGD93266.1 - 0.00045 20.4 0.0 0.0012 19.1 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.30 EGD93266.1 - 0.00092 19.6 0.0 0.0028 18.0 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeat Ank_3 PF13606.6 EGD93266.1 - 0.054 14.1 0.2 0.33 11.7 0.1 2.4 2 0 0 2 2 2 0 Ankyrin repeat TRP PF06011.12 EGD93267.1 - 2.5e-77 260.4 23.6 6.6e-77 259.0 23.7 1.6 1 1 0 1 1 1 1 Transient receptor potential (TRP) ion channel TRP_N PF14558.6 EGD93267.1 - 2.5e-31 108.9 0.0 4.5e-31 108.1 0.0 1.5 1 0 0 1 1 1 1 ML-like domain PIG-F PF06699.11 EGD93267.1 - 0.0069 16.6 0.9 0.0069 16.6 0.9 3.0 3 0 0 3 3 3 1 GPI biosynthesis protein family Pig-F DUF4501 PF14946.6 EGD93267.1 - 6.9 6.7 8.7 0.93 9.5 0.3 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4501) zf-C2H2 PF00096.26 EGD93273.1 - 8.3e-09 35.4 11.2 0.00051 20.3 1.5 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EGD93273.1 - 6.1e-05 23.3 10.4 6.2e-05 23.2 1.0 3.3 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 EGD93273.1 - 0.00059 20.4 9.8 0.12 13.3 1.9 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger zf-met PF12874.7 EGD93273.1 - 0.031 14.7 3.1 0.077 13.4 1.2 2.3 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 EGD93273.1 - 0.11 12.5 0.7 0.11 12.5 0.7 2.1 2 0 0 2 2 2 0 C2H2-type zinc finger Zn-ribbon_8 PF09723.10 EGD93273.1 - 0.47 10.6 3.0 11 6.3 0.2 2.4 1 1 1 2 2 2 0 Zinc ribbon domain zf-BED PF02892.15 EGD93273.1 - 2.9 8.0 7.6 1 9.5 1.0 2.4 2 0 0 2 2 2 0 BED zinc finger adh_short PF00106.25 EGD93274.1 - 1.6e-21 76.7 0.0 2.2e-17 63.2 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EGD93274.1 - 1.4e-10 41.2 0.0 5.5e-07 29.4 0.0 2.6 2 1 1 3 3 3 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EGD93274.1 - 3.2e-09 36.9 0.0 5.1e-09 36.3 0.0 1.3 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 EGD93274.1 - 0.0022 17.2 0.0 0.0034 16.6 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Sacchrp_dh_NADP PF03435.18 EGD93274.1 - 0.048 13.9 0.0 0.087 13.1 0.0 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain NAC PF01849.18 EGD93275.1 - 1.2e-24 86.0 0.5 1.2e-24 86.0 0.5 1.6 2 0 0 2 2 2 1 NAC domain Sigma70_ner PF04546.13 EGD93275.1 - 0.68 9.8 6.4 0.64 9.9 1.7 2.0 2 0 0 2 2 2 0 Sigma-70, non-essential region Rpr2 PF04032.16 EGD93276.1 - 1e-23 83.4 0.3 2e-23 82.5 0.3 1.5 1 1 0 1 1 1 1 RNAse P Rpr2/Rpp21/SNM1 subunit domain Mut7-C PF01927.16 EGD93276.1 - 0.038 14.1 0.5 0.045 13.9 0.5 1.3 1 0 0 1 1 1 0 Mut7-C RNAse domain zf-ribbon_3 PF13248.6 EGD93276.1 - 0.6 9.6 2.9 2 7.9 0.1 2.3 2 0 0 2 2 2 0 zinc-ribbon domain DEAD PF00270.29 EGD93277.1 - 9.6e-27 93.9 0.0 1.7e-26 93.1 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EGD93277.1 - 1.7e-26 92.7 0.0 5e-24 84.8 0.1 2.5 2 0 0 2 2 2 2 Helicase conserved C-terminal domain ResIII PF04851.15 EGD93277.1 - 1.5e-05 25.0 0.0 2.9e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CMS1 PF14617.6 EGD93277.1 - 0.00083 18.8 0.1 0.0044 16.4 0.0 2.0 2 0 0 2 2 2 1 U3-containing 90S pre-ribosomal complex subunit Ank_2 PF12796.7 EGD93278.1 - 4.5e-30 104.1 4.8 1.5e-09 38.3 0.0 5.1 3 2 2 5 5 5 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EGD93278.1 - 1.5e-20 73.3 9.8 5.9e-05 23.5 0.0 7.4 4 2 5 9 9 9 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EGD93278.1 - 3e-16 57.9 3.8 0.0013 19.1 0.0 7.7 8 0 0 8 8 8 4 Ankyrin repeat Ank_5 PF13857.6 EGD93278.1 - 6.1e-16 58.3 6.3 0.00015 21.9 0.1 5.0 3 2 1 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.30 EGD93278.1 - 1.4e-09 38.0 4.0 0.0049 17.3 0.0 6.8 8 0 0 8 8 8 2 Ankyrin repeat Sacchrp_dh_NADP PF03435.18 EGD93278.1 - 0.14 12.4 0.6 0.41 10.9 0.2 1.9 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain ApbA PF02558.16 EGD93279.1 - 6.6e-26 90.8 0.0 1e-25 90.1 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA ApbA_C PF08546.11 EGD93279.1 - 4.8e-22 78.5 0.0 7.9e-22 77.8 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal DASH_Hsk3 PF08227.11 EGD93280.1 - 1.3e-20 73.5 4.5 1.7e-20 73.1 4.5 1.2 1 0 0 1 1 1 1 DASH complex subunit Hsk3 like Sec2p PF06428.11 EGD93280.1 - 0.068 13.1 0.3 0.11 12.5 0.3 1.3 1 0 0 1 1 1 0 GDP/GTP exchange factor Sec2p DUF2076 PF09849.9 EGD93280.1 - 0.61 10.1 7.8 2.2 8.2 7.8 1.7 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) BBS2_C PF14782.6 EGD93281.1 - 0.0033 16.3 2.1 0.0039 16.0 2.1 1.0 1 0 0 1 1 1 1 Ciliary BBSome complex subunit 2, C-terminal L31 PF09784.9 EGD93281.1 - 0.058 13.8 0.5 0.081 13.4 0.5 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal protein L31 Lipase_3 PF01764.25 EGD93282.1 - 1e-16 61.1 0.0 5.3e-12 45.8 0.0 2.6 1 1 1 2 2 2 2 Lipase (class 3) Abhydrolase_6 PF12697.7 EGD93282.1 - 0.041 14.5 0.4 0.1 13.2 0.4 1.7 1 0 0 1 1 1 0 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EGD93282.1 - 0.12 11.6 0.0 0.23 10.7 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 RGS PF00615.19 EGD93283.1 - 3e-06 27.5 0.0 0.0019 18.5 0.0 2.2 2 0 0 2 2 2 2 Regulator of G protein signaling domain SMC_N PF02463.19 EGD93284.1 - 1.5e-21 76.8 0.0 2.8e-21 76.0 0.0 1.4 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 EGD93284.1 - 1e-11 45.2 1.7 1.6e-08 34.7 0.0 3.2 2 2 0 2 2 2 2 AAA ATPase domain AAA_23 PF13476.6 EGD93284.1 - 2.2e-11 44.7 63.4 1.2e-10 42.2 28.1 5.4 2 2 0 2 2 1 1 AAA domain AAA_21 PF13304.6 EGD93284.1 - 0.00015 21.7 2.9 0.069 13.0 0.0 3.3 4 0 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EGD93284.1 - 0.001 18.8 0.0 0.002 17.8 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain Baculo_PEP_C PF04513.12 EGD93284.1 - 0.017 15.2 11.1 1.7 8.7 0.4 4.5 2 1 2 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus Snapin_Pallidin PF14712.6 EGD93284.1 - 0.019 15.4 56.8 0.36 11.3 2.3 7.8 4 2 3 7 7 7 0 Snapin/Pallidin DUF4944 PF16302.5 EGD93284.1 - 0.23 11.5 1.3 2.1 8.4 0.4 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4944) AAA_27 PF13514.6 EGD93284.1 - 0.35 10.4 0.0 0.35 10.4 0.0 4.5 4 2 3 8 8 8 0 AAA domain ABC_tran PF00005.27 EGD93284.1 - 0.44 11.1 0.0 0.44 11.1 0.0 4.3 4 1 0 4 4 3 0 ABC transporter AAA_25 PF13481.6 EGD93284.1 - 2.1 7.9 7.6 0.83 9.2 0.0 3.2 3 0 0 3 3 3 0 AAA domain DUF4162 PF13732.6 EGD93284.1 - 8.5 7.2 12.4 2.3 9.0 1.5 4.4 3 1 1 4 4 4 0 Domain of unknown function (DUF4162) AdoMet_MTase PF07757.13 EGD93285.1 - 3.4e-36 124.0 0.0 1.2e-18 67.4 0.0 2.3 2 0 0 2 2 2 2 Predicted AdoMet-dependent methyltransferase DUF3237 PF11578.8 EGD93286.1 - 4.9e-33 114.1 0.0 7.5e-33 113.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3237) DUF2722 PF10846.8 EGD93286.1 - 1.6e-05 24.0 4.1 2.1e-05 23.7 4.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) zf-BED PF02892.15 EGD93286.1 - 0.00063 19.7 4.9 0.2 11.7 0.5 2.3 2 0 0 2 2 2 2 BED zinc finger Spt20 PF12090.8 EGD93286.1 - 0.011 15.4 19.2 0.022 14.4 19.2 1.5 1 0 0 1 1 1 0 Spt20 family SARAF PF06682.12 EGD93286.1 - 0.065 12.9 9.9 0.13 11.9 9.9 1.4 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis Activator_LAG-3 PF11498.8 EGD93286.1 - 0.13 11.2 23.5 0.3 10.0 23.5 1.6 1 0 0 1 1 1 0 Transcriptional activator LAG-3 Presenilin PF01080.17 EGD93286.1 - 0.26 10.0 0.8 0.32 9.7 0.8 1.2 1 0 0 1 1 1 0 Presenilin Pex14_N PF04695.13 EGD93286.1 - 0.27 11.9 20.9 0.036 14.7 9.9 2.3 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region PyrI_C PF02748.15 EGD93286.1 - 1.3 9.0 6.0 8.1 6.4 0.5 2.3 2 0 0 2 2 2 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain Coilin_N PF15862.5 EGD93286.1 - 1.7 8.5 5.7 3.9 7.3 5.7 1.6 1 0 0 1 1 1 0 Coilin N-terminus Ndc1_Nup PF09531.10 EGD93286.1 - 2.5 6.7 8.4 3.7 6.1 8.4 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup eIF-3_zeta PF05091.12 EGD93286.1 - 2.7 6.9 7.4 3.9 6.4 7.4 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Spore_coat_CotO PF14153.6 EGD93286.1 - 4 7.3 13.5 3.2 7.6 10.7 2.1 3 0 0 3 3 3 0 Spore coat protein CotO CCDC53 PF10152.9 EGD93286.1 - 4.5 7.7 15.0 0.74 10.2 5.5 2.3 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex DUF5327 PF17261.2 EGD93286.1 - 7.5 7.4 12.2 1.8 9.3 7.7 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5327) Gln-synt_C PF00120.24 EGD93287.1 - 1.3e-17 63.8 0.0 1.7e-17 63.5 0.0 1.0 1 0 0 1 1 1 1 Glutamine synthetase, catalytic domain adh_short_C2 PF13561.6 EGD93289.1 - 2.1e-60 204.2 0.2 2.3e-60 204.0 0.2 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EGD93289.1 - 4.4e-42 143.8 0.1 5.6e-42 143.4 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EGD93289.1 - 1.2e-11 44.9 0.7 1.9e-11 44.2 0.7 1.3 1 1 0 1 1 1 1 KR domain 3HCDH_N PF02737.18 EGD93289.1 - 0.00011 22.1 0.2 0.00021 21.2 0.2 1.5 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Methyltransf_25 PF13649.6 EGD93289.1 - 0.00035 21.2 0.0 0.00075 20.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Polysacc_synt_2 PF02719.15 EGD93289.1 - 0.011 14.9 0.0 0.016 14.4 0.0 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Epimerase PF01370.21 EGD93289.1 - 0.016 14.7 0.1 0.023 14.1 0.1 1.4 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Lig_C PF18330.1 EGD93289.1 - 0.045 13.8 0.0 0.068 13.2 0.0 1.2 1 0 0 1 1 1 0 Ligase Pab1020 C-terminal region RecC_C PF17946.1 EGD93289.1 - 0.046 13.5 0.0 0.077 12.8 0.0 1.3 1 0 0 1 1 1 0 RecC C-terminal domain 3Beta_HSD PF01073.19 EGD93289.1 - 0.059 12.4 0.1 0.26 10.2 0.1 1.9 1 1 1 2 2 2 0 3-beta hydroxysteroid dehydrogenase/isomerase family THF_DHG_CYH_C PF02882.19 EGD93289.1 - 0.06 12.7 0.2 0.16 11.3 0.2 1.7 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Ldh_1_N PF00056.23 EGD93289.1 - 0.062 13.4 0.9 0.28 11.3 0.5 2.0 1 1 1 2 2 2 0 lactate/malate dehydrogenase, NAD binding domain Methyltransf_12 PF08242.12 EGD93289.1 - 0.16 12.8 0.0 0.32 11.8 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain ChuX_HutX PF06228.13 EGD93289.1 - 0.16 11.7 0.0 13 5.6 0.0 2.3 1 1 0 2 2 2 0 Haem utilisation ChuX/HutX Eno-Rase_NADH_b PF12242.8 EGD93289.1 - 0.43 10.4 2.7 7.2 6.5 0.6 2.4 2 0 0 2 2 2 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Myco_arth_vir_N PF09610.10 EGD93289.1 - 0.73 10.0 3.7 8.7 6.5 1.4 2.5 2 0 0 2 2 2 0 Mycoplasma virulence signal region (Myco_arth_vir_N) BTB PF00651.31 EGD93290.1 - 0.0082 16.4 0.0 0.026 14.8 0.0 1.8 2 0 0 2 2 2 1 BTB/POZ domain CBP4 PF07960.11 EGD93291.1 - 2e-29 102.1 0.7 2.1e-29 102.0 0.7 1.0 1 0 0 1 1 1 1 CBP4 DUF4574 PF15141.6 EGD93291.1 - 0.0021 17.9 0.0 0.0034 17.3 0.0 1.3 1 1 0 1 1 1 1 Ubiquinol-cytochrome-c reductase complex assembly factor 3 Tmemb_161AB PF10268.9 EGD93291.1 - 0.098 11.3 0.1 0.098 11.3 0.1 1.2 1 0 0 1 1 1 0 Predicted transmembrane protein 161AB FERM_F2 PF18377.1 EGD93291.1 - 0.11 12.4 1.1 0.14 12.1 1.1 1.2 1 0 0 1 1 1 0 FERM F2 acyl-CoA binding protein-like domain Glyco_hydro_76 PF03663.14 EGD93292.1 - 4.1e-152 506.9 15.2 4.9e-152 506.7 15.2 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 Glyco_hydro_88 PF07470.13 EGD93292.1 - 0.00012 21.3 9.5 0.041 13.0 1.4 3.2 2 1 0 3 3 3 3 Glycosyl Hydrolase Family 88 Rad21_Rec8_N PF04825.13 EGD93293.1 - 4.9e-32 110.4 0.0 8.8e-32 109.5 0.0 1.4 1 0 0 1 1 1 1 N terminus of Rad21 / Rec8 like protein Rad21_Rec8 PF04824.16 EGD93293.1 - 0.013 14.8 0.1 0.03 13.6 0.1 1.6 1 0 0 1 1 1 0 Conserved region of Rad21 / Rec8 like protein T4BSS_DotH_IcmK PF12293.8 EGD93293.1 - 0.034 13.4 0.0 0.061 12.6 0.0 1.3 1 0 0 1 1 1 0 Putative outer membrane core complex of type IVb secretion DUF4006 PF13179.6 EGD93293.1 - 0.044 13.7 0.1 0.088 12.7 0.1 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF4006) NAT PF04768.13 EGD93294.1 - 4e-52 176.3 0.1 8.5e-52 175.2 0.0 1.6 2 0 0 2 2 2 1 NAT, N-acetyltransferase, of N-acetylglutamate synthase Semialdhyde_dh PF01118.24 EGD93294.1 - 8.9e-32 110.1 0.0 2.9e-31 108.4 0.0 2.0 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain AA_kinase PF00696.28 EGD93294.1 - 5.2e-28 98.3 0.3 1.5e-27 96.8 0.0 1.8 2 0 0 2 2 2 1 Amino acid kinase family Synaptobrevin PF00957.21 EGD93295.1 - 1.4e-32 111.3 1.6 1.6e-32 111.1 1.6 1.1 1 0 0 1 1 1 1 Synaptobrevin AKNA PF12443.8 EGD93295.1 - 0.046 14.4 0.2 0.11 13.2 0.1 1.6 1 1 1 2 2 2 0 AT-hook-containing transcription factor EMP24_GP25L PF01105.24 EGD93295.1 - 0.097 12.6 0.0 0.13 12.2 0.0 1.2 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD DUF1035 PF06281.12 EGD93295.1 - 0.21 11.6 1.5 0.4 10.7 1.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1035) Sel1 PF08238.12 EGD93297.1 - 5.4e-49 163.5 24.5 3.5e-09 37.0 0.1 7.5 7 0 0 7 7 7 7 Sel1 repeat L51_S25_CI-B8 PF05047.16 EGD93298.1 - 1.5e-13 50.4 0.0 2e-13 50.0 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain Glyco_hydro_36 PF17167.4 EGD93298.1 - 0.11 11.1 0.0 0.14 10.8 0.0 1.0 1 0 0 1 1 1 0 Glycosyl hydrolase 36 superfamily, catalytic domain MPC PF03650.13 EGD93299.1 - 2.3e-34 117.8 0.0 3.2e-34 117.4 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial pyruvate carriers Enoyl_reductase PF12241.8 EGD93299.1 - 0.028 13.8 0.0 0.034 13.5 0.0 1.1 1 0 0 1 1 1 0 Trans-2-enoyl-CoA reductase catalytic region FAD_binding_3 PF01494.19 EGD93300.1 - 1.8e-14 53.8 1.0 7.9e-14 51.7 1.0 1.8 1 1 0 1 1 1 1 FAD binding domain Amino_oxidase PF01593.24 EGD93300.1 - 0.035 13.4 0.0 0.063 12.5 0.0 1.4 1 0 0 1 1 1 0 Flavin containing amine oxidoreductase Methyltransf_23 PF13489.6 EGD93301.1 - 3.4e-21 75.8 0.0 3.4e-21 75.8 0.0 2.2 2 1 0 2 2 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EGD93301.1 - 9.1e-15 55.1 0.0 2.1e-14 54.0 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EGD93301.1 - 2.2e-13 50.7 0.0 4.5e-13 49.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EGD93301.1 - 9.7e-12 44.9 1.0 1.3e-10 41.3 0.0 2.7 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EGD93301.1 - 2.5e-10 41.0 0.1 1.2e-09 38.8 0.0 2.2 2 1 0 2 2 1 1 Methyltransferase domain CMAS PF02353.20 EGD93301.1 - 2.9e-06 26.8 0.0 5.2e-06 26.0 0.0 1.5 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Ubie_methyltran PF01209.18 EGD93301.1 - 3.5e-05 23.2 0.0 0.00069 19.0 0.0 2.2 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_2 PF00891.18 EGD93301.1 - 0.00015 21.1 0.0 0.0032 16.8 0.0 2.2 2 0 0 2 2 2 1 O-methyltransferase domain MTS PF05175.14 EGD93301.1 - 0.00027 20.5 0.0 0.0046 16.5 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase small domain PPP1R26_N PF15740.5 EGD93301.1 - 0.0016 17.2 4.0 0.0022 16.8 4.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 1 regulatory subunit 26 N-terminus PrmA PF06325.13 EGD93301.1 - 0.011 15.1 0.4 0.018 14.4 0.0 1.6 2 0 0 2 2 1 0 Ribosomal protein L11 methyltransferase (PrmA) FtsJ PF01728.19 EGD93301.1 - 0.021 15.0 0.0 0.043 13.9 0.0 1.4 1 0 0 1 1 1 0 FtsJ-like methyltransferase Methyltransf_16 PF10294.9 EGD93301.1 - 0.024 14.4 0.0 0.043 13.6 0.0 1.3 1 0 0 1 1 1 0 Lysine methyltransferase Methyltransf_4 PF02390.17 EGD93301.1 - 0.041 13.4 1.2 0.23 10.9 0.0 2.5 3 0 0 3 3 3 0 Putative methyltransferase Methyltransf_PK PF05891.12 EGD93301.1 - 0.13 11.8 0.1 0.25 10.8 0.1 1.4 1 0 0 1 1 1 0 AdoMet dependent proline di-methyltransferase GidB PF02527.15 EGD93301.1 - 0.2 11.0 0.0 0.41 10.0 0.0 1.6 1 0 0 1 1 1 0 rRNA small subunit methyltransferase G TFIIA PF03153.13 EGD93301.1 - 0.35 10.8 18.4 0.42 10.6 18.4 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit LRR19-TM PF15176.6 EGD93301.1 - 0.51 10.4 4.0 1 9.4 4.0 1.5 1 0 0 1 1 1 0 Leucine-rich repeat family 19 TM domain Paf1 PF03985.13 EGD93301.1 - 3.2 6.7 15.3 4.8 6.1 15.3 1.2 1 0 0 1 1 1 0 Paf1 DUF575 PF04746.12 EGD93303.1 - 0.00089 19.5 0.2 0.0016 18.7 0.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF575) Podoplanin PF05808.11 EGD93303.1 - 0.0019 18.3 0.6 0.0046 17.1 0.6 1.5 1 0 0 1 1 1 1 Podoplanin TMEM154 PF15102.6 EGD93303.1 - 0.014 15.3 0.0 0.03 14.2 0.0 1.5 1 0 0 1 1 1 0 TMEM154 protein family DAP10 PF07213.11 EGD93303.1 - 0.018 15.0 1.9 0.23 11.4 0.2 2.3 2 0 0 2 2 2 0 DAP10 membrane protein Sporozoite_P67 PF05642.11 EGD93303.1 - 0.044 11.9 3.9 0.054 11.6 3.9 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Ashwin PF15323.6 EGD93303.1 - 0.1 12.6 2.0 0.18 11.8 2.0 1.3 1 0 0 1 1 1 0 Developmental protein RIFIN PF02009.16 EGD93303.1 - 0.11 12.4 0.0 0.15 11.9 0.0 1.1 1 0 0 1 1 1 0 Rifin DUF5383 PF17355.2 EGD93303.1 - 0.11 12.8 0.0 0.18 12.2 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5383) DUF5305 PF17231.2 EGD93303.1 - 0.13 11.7 0.2 0.18 11.1 0.2 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5305) DUF2749 PF10907.8 EGD93303.1 - 1 9.6 2.8 3.6 7.8 2.8 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF2749) RAP1 PF07218.11 EGD93303.1 - 3.8 5.7 9.9 5.3 5.2 9.9 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) DUF515 PF04415.12 EGD93303.1 - 9.3 4.5 10.9 13 4.0 10.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF515) Malate_synthase PF01274.22 EGD93304.1 - 1.1e-227 756.4 0.0 1.3e-227 756.3 0.0 1.0 1 0 0 1 1 1 1 Malate synthase HpcH_HpaI PF03328.14 EGD93304.1 - 0.15 11.2 0.0 0.23 10.5 0.0 1.3 1 0 0 1 1 1 0 HpcH/HpaI aldolase/citrate lyase family PsbH PF00737.20 EGD93305.1 - 0.075 12.8 0.1 0.18 11.5 0.1 1.6 1 0 0 1 1 1 0 Photosystem II 10 kDa phosphoprotein FMO-like PF00743.19 EGD93306.1 - 1.4e-11 43.6 0.0 5.8e-08 31.6 0.1 2.6 2 1 0 2 2 2 2 Flavin-binding monooxygenase-like NAD_binding_8 PF13450.6 EGD93306.1 - 4.4e-10 39.7 0.1 2e-09 37.6 0.0 2.2 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EGD93306.1 - 1.4e-06 27.8 0.0 0.058 12.6 0.0 2.6 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EGD93306.1 - 3.2e-05 23.7 0.3 0.0049 16.5 0.3 3.2 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 EGD93306.1 - 0.016 15.2 0.0 0.13 12.3 0.0 2.3 2 0 0 2 2 2 0 FAD-NAD(P)-binding K_oxygenase PF13434.6 EGD93306.1 - 0.022 13.9 0.1 0.6 9.2 0.0 2.8 2 1 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox PF00070.27 EGD93306.1 - 0.071 13.7 0.8 0.82 10.3 0.0 2.8 2 1 1 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EGD93306.1 - 0.21 10.8 0.1 0.49 9.6 0.0 1.5 2 0 0 2 2 2 0 Thi4 family HI0933_like PF03486.14 EGD93306.1 - 0.3 9.7 0.6 0.5 9.0 0.0 1.6 2 0 0 2 2 2 0 HI0933-like protein Glyco_hydro_3_C PF01915.22 EGD93307.1 - 2.6e-38 132.0 0.0 4.7e-38 131.2 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 EGD93307.1 - 1.8e-35 122.9 0.0 2.5e-35 122.4 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 EGD93307.1 - 2.1e-22 79.0 0.1 4.7e-22 77.9 0.1 1.6 1 0 0 1 1 1 1 Fibronectin type III-like domain Serpin PF00079.20 EGD93308.1 - 1.9e-53 182.1 0.0 2.5e-53 181.7 0.0 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) AA_permease_2 PF13520.6 EGD93309.1 - 6.5e-52 176.8 55.0 8e-52 176.5 55.0 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EGD93309.1 - 1.5e-19 69.9 40.7 2.1e-19 69.5 40.7 1.1 1 0 0 1 1 1 1 Amino acid permease DUF4668 PF15701.5 EGD93309.1 - 1.2 8.9 5.6 0.45 10.3 0.1 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4668) LapA_dom PF06305.11 EGD93309.1 - 2.8 7.8 6.2 0.44 10.4 0.1 2.8 3 0 0 3 3 3 0 Lipopolysaccharide assembly protein A domain GST_N_2 PF13409.6 EGD93311.1 - 5.2e-12 45.9 0.0 1.1e-11 44.8 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 EGD93311.1 - 3e-09 37.2 0.0 6e-09 36.2 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EGD93311.1 - 4.8e-05 23.3 0.1 0.00033 20.6 0.0 2.3 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EGD93311.1 - 0.00053 20.2 0.0 0.00098 19.3 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EGD93311.1 - 0.0012 19.0 0.0 0.0025 18.0 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain ABC_tran PF00005.27 EGD93312.1 - 4.2e-44 150.4 0.1 2.2e-24 86.5 0.0 4.0 2 2 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 EGD93312.1 - 5.6e-14 52.6 1.2 0.00044 20.2 0.0 4.5 4 0 0 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EGD93312.1 - 6.7e-11 42.0 0.3 0.0014 18.1 0.0 4.2 2 2 0 3 3 3 2 RecF/RecN/SMC N terminal domain Chromo PF00385.24 EGD93312.1 - 2.4e-08 33.7 0.1 5e-08 32.7 0.1 1.6 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain MMR_HSR1 PF01926.23 EGD93312.1 - 2.3e-07 30.9 0.0 0.013 15.6 0.0 3.1 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_23 PF13476.6 EGD93312.1 - 5.6e-07 30.3 0.9 0.0058 17.2 0.0 3.1 3 0 0 3 3 3 2 AAA domain RsgA_GTPase PF03193.16 EGD93312.1 - 2.1e-06 27.7 0.1 0.027 14.4 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase AAA_29 PF13555.6 EGD93312.1 - 1.7e-05 24.5 2.5 0.11 12.3 1.2 2.9 2 1 1 3 3 3 2 P-loop containing region of AAA domain NACHT PF05729.12 EGD93312.1 - 0.0003 20.8 0.7 0.14 12.0 0.0 2.8 2 0 0 2 2 2 1 NACHT domain DUF87 PF01935.17 EGD93312.1 - 0.0004 20.5 1.3 0.064 13.4 0.1 3.4 3 0 0 3 3 2 1 Helicase HerA, central domain AAA_28 PF13521.6 EGD93312.1 - 0.0019 18.5 0.0 0.015 15.5 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_15 PF13175.6 EGD93312.1 - 0.0027 17.5 0.1 0.89 9.2 0.1 2.5 2 0 0 2 2 2 1 AAA ATPase domain RNA_helicase PF00910.22 EGD93312.1 - 0.0047 17.3 0.2 5 7.6 0.0 2.8 2 0 0 2 2 2 1 RNA helicase AAA_22 PF13401.6 EGD93312.1 - 0.007 16.6 0.0 6.4 7.1 0.0 3.2 2 0 0 2 2 2 0 AAA domain SbcCD_C PF13558.6 EGD93312.1 - 0.0078 16.4 0.0 8.2 6.7 0.0 3.4 2 2 0 2 2 2 0 Putative exonuclease SbcCD, C subunit ALF PF03752.13 EGD93312.1 - 0.031 14.3 2.2 0.26 11.3 0.6 2.7 2 0 0 2 2 2 0 Short repeats of unknown function AAA_18 PF13238.6 EGD93312.1 - 0.031 14.8 0.5 4.8 7.7 0.0 3.4 3 0 0 3 3 3 0 AAA domain MeaB PF03308.16 EGD93312.1 - 0.037 13.0 0.4 7.3 5.5 0.0 2.4 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Ploopntkinase3 PF18751.1 EGD93312.1 - 0.041 13.8 0.0 3.3 7.6 0.0 2.4 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 Roc PF08477.13 EGD93312.1 - 0.044 14.0 0.1 8.8 6.6 0.0 2.7 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase SR-25 PF10500.9 EGD93312.1 - 0.057 13.0 0.5 0.11 12.1 0.5 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein AAA_30 PF13604.6 EGD93312.1 - 0.065 12.9 0.6 1.2 8.8 0.2 2.7 2 0 0 2 2 2 0 AAA domain MukB PF04310.12 EGD93312.1 - 0.071 12.9 0.4 2 8.2 0.1 2.4 2 0 0 2 2 2 0 MukB N-terminal ATP-synt_ab PF00006.25 EGD93312.1 - 0.072 12.7 0.1 15 5.2 0.0 2.7 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain HEAT PF02985.22 EGD93312.1 - 0.077 13.3 0.3 1.1e+02 3.5 0.0 4.5 5 0 0 5 5 4 0 HEAT repeat PduV-EutP PF10662.9 EGD93312.1 - 0.092 12.5 0.1 0.92 9.3 0.0 2.4 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_24 PF13479.6 EGD93312.1 - 0.097 12.4 1.1 2 8.1 0.1 2.4 2 0 0 2 2 2 0 AAA domain DUF1666 PF07891.12 EGD93312.1 - 0.11 12.1 0.1 0.34 10.5 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1666) NB-ARC PF00931.22 EGD93312.1 - 0.13 11.5 1.0 3.7 6.7 0.0 2.6 3 0 0 3 3 3 0 NB-ARC domain Glyco_hydro_92 PF07971.12 EGD93313.1 - 1.6e-147 492.2 0.4 1.9e-147 491.9 0.4 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 Glyco_hydro_92N PF17678.1 EGD93313.1 - 4.5e-60 203.5 0.7 7.3e-60 202.8 0.7 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 N-terminal domain Citrate_synt PF00285.21 EGD93314.1 - 3.6e-98 328.9 0.0 4.3e-98 328.7 0.0 1.0 1 0 0 1 1 1 1 Citrate synthase, C-terminal domain ICL PF00463.21 EGD93315.1 - 1.2e-194 647.7 0.1 1.4e-194 647.5 0.1 1.0 1 0 0 1 1 1 1 Isocitrate lyase family PEP_mutase PF13714.6 EGD93315.1 - 2.6e-10 40.2 0.0 1.5e-09 37.7 0.0 1.9 1 1 0 2 2 2 1 Phosphoenolpyruvate phosphomutase AMP-binding PF00501.28 EGD93316.1 - 4e-65 220.1 0.0 4.9e-65 219.8 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EGD93316.1 - 2.7e-06 28.3 0.1 7.3e-06 26.9 0.1 1.8 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain DUF1661 PF07877.11 EGD93316.1 - 0.12 12.0 0.4 0.31 10.7 0.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1661) MmgE_PrpD PF03972.14 EGD93317.1 - 2.4e-146 487.7 0.0 2.9e-146 487.5 0.0 1.0 1 0 0 1 1 1 1 MmgE/PrpD family DNA_methylase PF00145.17 EGD93318.1 - 5e-43 147.7 0.0 9.3e-33 114.0 0.0 2.1 1 1 1 2 2 2 2 C-5 cytosine-specific DNA methylase GATase_6 PF13522.6 EGD93319.1 - 1.4e-13 51.2 0.0 3.1e-13 50.1 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.6 EGD93319.1 - 2.4e-11 43.6 0.0 7.2e-11 42.1 0.0 1.9 1 0 0 1 1 1 1 Glutamine amidotransferase domain Pribosyltran PF00156.27 EGD93319.1 - 2.7e-07 30.2 0.1 6.9e-07 28.9 0.1 1.6 1 0 0 1 1 1 1 Phosphoribosyl transferase domain GATase_4 PF13230.6 EGD93319.1 - 0.00057 18.9 0.0 0.0013 17.7 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferases class-II HhH-GPD PF00730.25 EGD93320.1 - 7.2e-08 32.8 0.0 1.3e-07 32.0 0.0 1.4 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein Aldedh PF00171.22 EGD93321.1 - 1.7e-122 409.3 0.0 2e-122 409.0 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF2992 PF11208.8 EGD93322.1 - 0.014 15.6 3.7 0.036 14.3 3.7 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2992) Pkinase PF00069.25 EGD93323.1 - 6.2e-28 97.9 0.0 1e-27 97.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD93323.1 - 9.1e-18 64.5 0.0 1.4e-17 63.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EGD93323.1 - 0.0042 17.1 0.0 0.0073 16.3 0.0 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kinase-like PF14531.6 EGD93323.1 - 0.012 15.0 0.0 0.019 14.3 0.0 1.2 1 0 0 1 1 1 0 Kinase-like Pkinase_fungal PF17667.1 EGD93323.1 - 0.013 14.3 0.1 0.021 13.6 0.1 1.2 1 0 0 1 1 1 0 Fungal protein kinase Kdo PF06293.14 EGD93323.1 - 0.029 13.7 0.1 0.051 12.9 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family F-box-like_2 PF13013.6 EGD93324.1 - 0.067 13.2 0.1 0.4 10.7 0.1 2.2 2 0 0 2 2 2 0 F-box-like domain F-box-like PF12937.7 EGD93324.1 - 0.11 12.4 0.4 0.26 11.2 0.4 1.6 1 0 0 1 1 1 0 F-box-like Mt_ATP-synt_D PF05873.12 EGD93326.1 - 7.2e-24 84.4 2.4 8.8e-24 84.1 2.4 1.1 1 0 0 1 1 1 1 ATP synthase D chain, mitochondrial (ATP5H) E3_UbLigase_R4 PF13764.6 EGD93326.1 - 0.014 13.6 0.5 0.015 13.5 0.5 1.0 1 0 0 1 1 1 0 E3 ubiquitin-protein ligase UBR4 T2SSM_b PF10741.9 EGD93326.1 - 0.021 14.6 0.3 0.088 12.6 0.0 2.0 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein M subtype b DUF948 PF06103.11 EGD93326.1 - 0.12 12.7 1.5 0.88 9.9 0.4 2.6 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) NAC PF01849.18 EGD93327.1 - 3.2e-22 78.2 0.0 1.1e-21 76.5 0.0 1.9 2 0 0 2 2 2 1 NAC domain Cytomega_UL84 PF06284.11 EGD93327.1 - 0.15 10.5 0.5 0.17 10.3 0.5 1.1 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein Shadoo PF14999.6 EGD93327.1 - 0.2 11.8 3.5 0.36 10.9 3.5 1.4 1 0 0 1 1 1 0 Shadow of prion protein, neuroprotective PGA2 PF07543.12 EGD93327.1 - 7.1 6.6 12.3 3.3 7.7 8.1 2.0 2 0 0 2 2 2 0 Protein trafficking PGA2 Myc_N PF01056.18 EGD93327.1 - 8.8 6.1 9.4 2.1 8.2 5.8 1.6 1 1 1 2 2 2 0 Myc amino-terminal region Ribosomal_L14e PF01929.17 EGD93328.1 - 4.4e-31 107.2 1.9 6.1e-31 106.7 1.9 1.2 1 0 0 1 1 1 1 Ribosomal protein L14 KOW PF00467.29 EGD93328.1 - 9.5e-07 28.6 1.0 1.9e-06 27.6 0.1 1.9 2 0 0 2 2 2 1 KOW motif MFS_1 PF07690.16 EGD93329.1 - 1.1e-33 116.6 26.6 3.2e-21 75.6 12.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EGD93329.1 - 4.6e-10 38.9 11.6 2.4e-09 36.6 4.4 2.3 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_4 PF06779.14 EGD93329.1 - 4.7e-05 22.9 3.0 4.7e-05 22.9 3.0 2.4 2 1 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB MFS_2 PF13347.6 EGD93329.1 - 6.9e-05 21.6 11.7 0.032 12.8 1.8 3.4 2 2 1 3 3 3 3 MFS/sugar transport protein MFS_1_like PF12832.7 EGD93329.1 - 0.00016 20.7 8.4 0.0038 16.2 0.2 3.3 2 2 1 3 3 3 3 MFS_1 like family Folate_carrier PF01770.18 EGD93329.1 - 0.0047 15.7 0.0 0.0083 14.9 0.0 1.3 1 0 0 1 1 1 1 Reduced folate carrier SRP-alpha_N PF04086.13 EGD93330.1 - 3.3e-75 253.7 0.0 4.4e-75 253.3 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle, alpha subunit, N-terminal SRP54 PF00448.22 EGD93330.1 - 1.5e-50 171.6 0.0 2.5e-50 170.9 0.0 1.4 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain SRP54_N PF02881.19 EGD93330.1 - 6.8e-10 39.0 0.1 1.9e-09 37.6 0.1 1.8 1 0 0 1 1 1 1 SRP54-type protein, helical bundle domain MeaB PF03308.16 EGD93330.1 - 2e-06 27.0 0.0 3.6e-06 26.2 0.0 1.3 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_30 PF13604.6 EGD93330.1 - 0.00075 19.3 0.0 0.002 17.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.6 EGD93330.1 - 0.0068 16.1 0.0 0.013 15.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EGD93330.1 - 0.0079 16.6 0.0 0.027 14.9 0.0 1.9 2 0 0 2 2 2 1 AAA ATPase domain CbiA PF01656.23 EGD93330.1 - 0.011 15.7 0.0 0.043 13.9 0.0 2.0 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain MMR_HSR1 PF01926.23 EGD93330.1 - 0.028 14.5 0.1 0.15 12.1 0.1 2.3 2 1 0 2 2 2 0 50S ribosome-binding GTPase AAA_31 PF13614.6 EGD93330.1 - 0.028 14.3 0.2 0.25 11.2 0.0 2.1 1 1 1 2 2 2 0 AAA domain AAA_17 PF13207.6 EGD93330.1 - 0.048 14.1 0.1 0.29 11.6 0.0 2.3 2 0 0 2 2 2 0 AAA domain Fer4_NifH PF00142.18 EGD93330.1 - 0.053 13.0 0.0 0.1 12.0 0.0 1.4 1 0 0 1 1 1 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family AAA_33 PF13671.6 EGD93330.1 - 0.085 13.0 0.0 0.22 11.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain ArsA_ATPase PF02374.15 EGD93330.1 - 0.13 11.4 0.2 13 4.9 0.0 2.3 1 1 1 2 2 2 0 Anion-transporting ATPase YIF1 PF03878.15 EGD93331.1 - 2.8e-98 328.2 4.0 3.3e-98 328.0 4.0 1.0 1 0 0 1 1 1 1 YIF1 Catalase PF00199.19 EGD93332.1 - 2.4e-174 579.9 0.9 3e-174 579.6 0.9 1.1 1 0 0 1 1 1 1 Catalase Catalase-rel PF06628.12 EGD93332.1 - 1.7e-16 60.2 0.0 3.2e-16 59.3 0.0 1.5 1 0 0 1 1 1 1 Catalase-related immune-responsive Catalase_C PF18011.1 EGD93332.1 - 2.1e-08 33.9 0.3 1.4e-07 31.3 0.0 2.4 3 0 0 3 3 3 1 C-terminal domain found in long catalases DJ-1_PfpI PF01965.24 EGD93332.1 - 0.00044 20.1 0.0 0.00093 19.0 0.0 1.5 1 0 0 1 1 1 1 DJ-1/PfpI family RabGAP-TBC PF00566.18 EGD93335.1 - 5.8e-38 130.7 4.7 1.1e-37 129.8 4.7 1.5 1 1 0 1 1 1 1 Rab-GTPase-TBC domain PH_RBD PF12068.8 EGD93335.1 - 1.3e-06 28.0 0.0 0.00089 18.8 0.0 3.5 3 1 0 3 3 3 1 Rab-binding domain (RBD) GAS2 PF02187.17 EGD93336.1 - 4.4e-06 26.7 0.3 1e-05 25.6 0.3 1.5 1 0 0 1 1 1 1 Growth-Arrest-Specific Protein 2 Domain Hus1 PF04005.12 EGD93337.1 - 2.5e-108 361.6 0.0 2.9e-108 361.4 0.0 1.0 1 0 0 1 1 1 1 Hus1-like protein Sec16_C PF12931.7 EGD93338.1 - 1.3e-109 366.5 0.2 1.8e-109 366.0 0.2 1.2 1 0 0 1 1 1 1 Sec23-binding domain of Sec16 Sec16_N PF12935.7 EGD93338.1 - 1.7e-54 185.5 22.0 1.7e-54 185.5 22.0 4.7 4 1 0 4 4 4 2 Vesicle coat trafficking protein Sec16 N-terminus Sec16 PF12932.7 EGD93338.1 - 1.3e-32 112.8 0.1 3.4e-32 111.5 0.1 1.8 1 0 0 1 1 1 1 Vesicle coat trafficking protein Sec16 mid-region GIY-YIG PF01541.24 EGD93339.1 - 0.035 14.4 0.1 0.079 13.2 0.1 1.6 1 0 0 1 1 1 0 GIY-YIG catalytic domain PhoLip_ATPase_C PF16212.5 EGD93340.1 - 1.8e-46 158.9 7.3 1.8e-46 158.9 7.3 2.2 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EGD93340.1 - 4.6e-16 58.3 1.7 9.3e-16 57.3 1.7 1.5 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.26 EGD93340.1 - 8.3e-13 49.1 0.1 8e-08 32.8 0.1 3.4 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EGD93340.1 - 1.8e-09 37.6 0.1 1.2e-06 28.5 0.0 3.7 3 1 0 3 3 3 1 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.20 EGD93340.1 - 1.1e-05 25.1 1.4 0.023 14.2 0.0 2.5 2 0 0 2 2 2 2 E1-E2 ATPase Hydrolase_3 PF08282.12 EGD93340.1 - 0.012 15.4 0.0 0.03 14.1 0.0 1.6 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase HIGH_NTase1_ass PF16581.5 EGD93340.1 - 0.032 14.2 0.1 0.078 13.0 0.0 1.6 2 0 0 2 2 2 0 Cytidyltransferase-related C-terminal region Mso1_Sec1_bdg PF14475.6 EGD93341.1 - 4.8e-13 48.5 0.0 8.3e-13 47.7 0.0 1.5 1 0 0 1 1 1 1 Sec1-binding region of Mso1 Sporozoite_P67 PF05642.11 EGD93341.1 - 1.5 6.9 6.4 2 6.4 6.4 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Ribosomal_L28e PF01778.17 EGD93342.1 - 1.5e-38 132.1 0.6 2.6e-38 131.3 0.6 1.4 1 0 0 1 1 1 1 Ribosomal L28e protein family Mak16 PF04874.14 EGD93342.1 - 3e-30 104.8 14.0 3e-30 104.8 14.0 2.3 2 0 0 2 2 2 1 Mak16 protein C-terminal region BUD22 PF09073.10 EGD93342.1 - 9.2e-06 25.3 14.6 1.1e-05 25.0 14.6 1.1 1 0 0 1 1 1 1 BUD22 Ribosomal_L24e PF01246.20 EGD93342.1 - 0.0085 16.3 0.3 0.022 15.0 0.3 1.7 1 0 0 1 1 1 1 Ribosomal protein L24e PYC_OADA PF02436.18 EGD93342.1 - 0.025 14.3 1.3 0.043 13.6 0.9 1.5 1 1 0 1 1 1 0 Conserved carboxylase domain TFIIF_alpha PF05793.12 EGD93342.1 - 0.091 11.3 24.7 0.11 11.1 24.7 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Nop14 PF04147.12 EGD93342.1 - 4.9 5.2 27.4 6 4.9 27.4 1.1 1 0 0 1 1 1 0 Nop14-like family zf-C2H2_4 PF13894.6 EGD93343.1 - 2.2e-08 34.2 29.2 0.52 11.3 0.7 6.3 6 0 0 6 6 6 5 C2H2-type zinc finger zf-C2H2 PF00096.26 EGD93343.1 - 0.0058 17.0 27.7 1.3 9.6 1.9 6.0 6 0 0 6 6 6 3 Zinc finger, C2H2 type zf-C2H2_2 PF12756.7 EGD93343.1 - 0.07 13.5 17.3 0.34 11.3 3.9 3.6 1 1 3 4 4 4 0 C2H2 type zinc-finger (2 copies) zf-B_box PF00643.24 EGD93343.1 - 2.3 8.5 27.4 0.31 11.2 0.9 4.8 4 1 0 4 4 4 0 B-box zinc finger zf_C2H2_ZHX PF18387.1 EGD93343.1 - 5.9 6.6 16.9 0.084 12.5 0.9 3.7 2 1 2 4 4 4 0 Zinc-fingers and homeoboxes C2H2 finger domain ECH_1 PF00378.20 EGD93344.1 - 4.2e-25 88.5 0.0 5.3e-25 88.2 0.0 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EGD93344.1 - 1.7e-18 67.2 0.0 1.9e-18 67.1 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase D123 PF07065.14 EGD93345.1 - 5.1e-109 364.1 0.1 6.5e-109 363.8 0.1 1.1 1 0 0 1 1 1 1 D123 Vps51 PF08700.11 EGD93346.1 - 2.5e-13 49.9 0.0 1.7e-12 47.2 0.0 2.5 1 0 0 1 1 1 1 Vps51/Vps67 DUF1640 PF07798.11 EGD93347.1 - 5.7e-35 120.9 8.5 8.3e-35 120.4 8.5 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1640) HIP1_clath_bdg PF16515.5 EGD93347.1 - 0.0011 19.5 2.1 0.0036 17.9 2.1 1.9 1 0 0 1 1 1 1 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF1387 PF07139.11 EGD93347.1 - 0.17 11.6 17.3 1.6 8.4 15.5 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1387) Baculo_PEP_C PF04513.12 EGD93347.1 - 0.85 9.7 5.9 1.5 8.8 5.9 1.4 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus ALMT PF11744.8 EGD93347.1 - 4.8 5.9 12.5 0.029 13.2 2.3 2.3 1 1 1 2 2 2 0 Aluminium activated malate transporter HEAT_2 PF13646.6 EGD93348.1 - 2.8e-08 34.0 0.0 0.32 11.4 0.0 5.9 4 1 0 4 4 4 2 HEAT repeats HEAT PF02985.22 EGD93348.1 - 4.3e-06 26.5 9.0 3.2 8.2 0.0 8.6 9 0 0 9 9 9 2 HEAT repeat Vac14_Fab1_bd PF12755.7 EGD93348.1 - 0.00051 20.6 0.0 0.1 13.2 0.0 4.0 3 0 0 3 3 3 1 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.6 EGD93348.1 - 0.0053 17.2 13.0 28 5.4 0.1 7.0 7 0 0 7 7 7 0 HEAT-like repeat Arm PF00514.23 EGD93348.1 - 0.023 14.8 3.2 3.6 7.8 0.0 4.9 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat RTP1_C1 PF10363.9 EGD93348.1 - 0.11 12.7 0.1 41 4.4 0.0 4.3 4 0 0 4 4 4 0 Required for nuclear transport of RNA pol II C-terminus 1 V-ATPase_H_N PF03224.14 EGD93348.1 - 0.51 9.6 5.0 2.4 7.4 0.1 3.7 3 1 0 3 3 3 0 V-ATPase subunit H Cnd1 PF12717.7 EGD93348.1 - 0.82 9.7 6.3 2.1 8.4 0.0 4.3 5 0 0 5 5 5 0 non-SMC mitotic condensation complex subunit 1 Transcrip_reg PF01709.20 EGD93349.1 - 5.6e-73 245.3 0.1 6.4e-73 245.1 0.1 1.0 1 0 0 1 1 1 1 Transcriptional regulator CENP-I PF07778.11 EGD93350.1 - 4.2e-47 161.0 0.9 2.6e-46 158.4 0.9 1.9 1 1 0 1 1 1 1 Mis6 Sedlin_N PF04628.13 EGD93350.1 - 0.037 14.1 0.0 0.31 11.2 0.0 2.4 2 0 0 2 2 2 0 Sedlin, N-terminal conserved region DUF4360 PF14273.6 EGD93351.1 - 1.3e-70 236.9 2.8 1.6e-70 236.6 2.8 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4360) CLPTM1 PF05602.12 EGD93353.1 - 7.3e-123 410.8 2.6 3.9e-94 316.1 0.1 2.1 1 1 1 2 2 2 2 Cleft lip and palate transmembrane protein 1 (CLPTM1) adh_short PF00106.25 EGD93354.1 - 4.7e-20 71.9 0.0 9.9e-20 70.8 0.0 1.6 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EGD93354.1 - 9.4e-15 54.8 0.0 1.5e-14 54.1 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase ASXH PF13919.6 EGD93355.1 - 6.9e-36 123.3 1.0 1.6e-35 122.1 1.0 1.7 1 0 0 1 1 1 1 Asx homology domain Longin PF13774.6 EGD93356.1 - 1.1e-25 89.4 0.6 1.9e-25 88.7 0.6 1.4 1 0 0 1 1 1 1 Regulated-SNARE-like domain Synaptobrevin PF00957.21 EGD93356.1 - 1.8e-15 56.5 0.8 6.1e-15 54.8 0.0 1.9 2 0 0 2 2 2 1 Synaptobrevin SLM4 PF16818.5 EGD93356.1 - 0.01 15.8 1.3 0.18 11.7 0.0 2.1 1 1 1 2 2 2 0 Protein SLM4 Bac_small_YrzI PF09501.10 EGD93356.1 - 0.11 12.7 0.5 0.23 11.6 0.5 1.6 1 0 0 1 1 1 0 Probable sporulation protein (Bac_small_yrzI) SCVP PF17619.2 EGD93356.1 - 0.12 13.2 1.2 1.3 9.9 0.1 2.2 2 0 0 2 2 2 0 Secreted clade V proteins DUF1664 PF07889.12 EGD93356.1 - 0.29 11.2 6.2 0.23 11.5 0.5 2.4 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) SIMPL PF04402.14 EGD93356.1 - 0.5 10.8 4.0 1.5 9.2 4.0 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF541) YgaB PF14182.6 EGD93356.1 - 1.1 9.7 4.2 0.65 10.4 0.4 2.3 2 1 1 3 3 3 0 YgaB-like protein EMP24_GP25L PF01105.24 EGD93356.1 - 2.3 8.1 6.4 1.5 8.7 0.7 2.2 1 1 1 2 2 2 0 emp24/gp25L/p24 family/GOLD Elong_Iki1 PF10483.9 EGD93357.1 - 1.5e-98 330.0 0.0 1.9e-98 329.6 0.0 1.1 1 0 0 1 1 1 1 Elongator subunit Iki1 SNRNP27 PF08648.12 EGD93358.1 - 1.6e-26 92.1 1.8 3.7e-26 91.0 1.8 1.6 1 0 0 1 1 1 1 U4/U6.U5 small nuclear ribonucleoproteins DAO PF01266.24 EGD93359.1 - 1.4e-70 238.6 1.0 1.6e-70 238.4 1.0 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EGD93359.1 - 1.5e-07 31.5 0.3 6e-07 29.6 0.3 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EGD93359.1 - 5.4e-07 29.1 0.1 0.0078 15.5 0.1 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EGD93359.1 - 0.00015 21.0 0.3 0.0024 17.0 0.1 2.1 2 0 0 2 2 2 1 FAD binding domain Thi4 PF01946.17 EGD93359.1 - 0.00086 18.6 0.1 0.0016 17.7 0.1 1.4 1 0 0 1 1 1 1 Thi4 family Pyr_redox PF00070.27 EGD93359.1 - 0.00088 19.8 0.1 0.013 16.1 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 EGD93359.1 - 0.0017 17.3 0.1 0.12 11.2 0.0 2.1 2 0 0 2 2 2 1 Tryptophan halogenase MCRA PF06100.11 EGD93359.1 - 0.0064 15.3 0.3 0.012 14.4 0.1 1.4 2 0 0 2 2 2 1 MCRA family GIDA PF01134.22 EGD93359.1 - 0.01 15.0 0.1 1.1 8.2 0.0 2.2 2 0 0 2 2 2 2 Glucose inhibited division protein A NAD_binding_9 PF13454.6 EGD93359.1 - 0.016 15.2 0.2 0.099 12.6 0.1 2.1 2 0 0 2 2 2 0 FAD-NAD(P)-binding FAD_oxidored PF12831.7 EGD93359.1 - 0.025 13.9 0.6 0.52 9.6 0.6 2.1 1 1 0 1 1 1 0 FAD dependent oxidoreductase Sacchrp_dh_NADP PF03435.18 EGD93359.1 - 0.029 14.6 0.1 0.2 11.9 0.1 2.2 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain Mqo PF06039.15 EGD93359.1 - 0.14 10.7 0.0 9.2 4.7 0.0 2.1 2 0 0 2 2 2 0 Malate:quinone oxidoreductase (Mqo) Glyco_hydro_63 PF03200.16 EGD93360.1 - 5.1e-175 582.9 5.2 5.1e-175 582.9 5.2 2.7 2 1 0 2 2 2 1 Glycosyl hydrolase family 63 C-terminal domain Glyco_hydro_63N PF16923.5 EGD93360.1 - 1.1e-88 297.1 0.0 9.5e-88 294.1 0.0 2.2 3 0 0 3 3 3 1 Glycosyl hydrolase family 63 N-terminal domain Trehalase PF01204.18 EGD93360.1 - 0.002 17.0 0.9 0.0043 16.0 0.9 1.4 1 1 0 1 1 1 1 Trehalase MMtag PF10159.9 EGD93361.1 - 2.5e-33 114.2 3.2 2.5e-33 114.2 3.2 2.3 2 1 0 2 2 2 1 Multiple myeloma tumor-associated PAP1 PF08601.10 EGD93361.1 - 0.58 9.8 3.6 0.9 9.2 3.6 1.2 1 0 0 1 1 1 0 Transcription factor PAP1 CRT10 PF08728.10 EGD93362.1 - 2.8e-15 55.6 0.1 4.9e-09 34.9 0.0 2.2 2 0 0 2 2 2 2 CRT10 DUF568 PF04526.13 EGD93362.1 - 0.12 13.1 0.2 0.28 11.9 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF568) YL1 PF05764.13 EGD93362.1 - 6.6 6.8 15.6 12 6.0 15.6 1.3 1 0 0 1 1 1 0 YL1 nuclear protein DUF3402 PF11882.8 EGD93363.1 - 1.7e-169 564.8 0.0 2.2e-169 564.5 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3402) N1221 PF07923.13 EGD93363.1 - 1.6e-85 286.8 0.0 2.2e-85 286.3 0.0 1.2 1 0 0 1 1 1 1 N1221-like protein IBR PF01485.21 EGD93364.1 - 2.3e-18 66.2 41.4 7.3e-16 58.1 3.3 4.1 3 1 1 4 4 4 2 IBR domain, a half RING-finger domain RWD PF05773.22 EGD93364.1 - 3.1e-17 62.9 0.1 8.5e-17 61.5 0.1 1.8 1 1 0 1 1 1 1 RWD domain zf-RING_2 PF13639.6 EGD93364.1 - 0.027 14.8 9.1 0.027 14.8 9.1 4.1 3 1 1 4 4 4 0 Ring finger domain PAP2 PF01569.21 EGD93365.1 - 8.4e-14 51.5 6.2 1.6e-13 50.6 4.8 2.1 1 1 0 1 1 1 1 PAP2 superfamily DUF212 PF02681.14 EGD93365.1 - 0.002 18.3 0.1 0.69 10.1 0.0 2.3 2 0 0 2 2 2 2 Divergent PAP2 family Ldh_2 PF02615.14 EGD93366.1 - 3.4e-128 427.5 0.2 3.8e-128 427.3 0.2 1.0 1 0 0 1 1 1 1 Malate/L-lactate dehydrogenase Pet100 PF09803.9 EGD93367.1 - 2.7e-19 69.5 0.1 3.2e-19 69.2 0.1 1.2 1 0 0 1 1 1 1 Pet100 CSN7a_helixI PF18392.1 EGD93367.1 - 0.24 11.4 0.6 0.34 10.8 0.6 1.2 1 0 0 1 1 1 0 COP9 signalosome complex subunit 7a helix I domain SPT_ssu-like PF11779.8 EGD93368.1 - 9.8e-23 79.5 4.3 1.3e-22 79.1 4.3 1.2 1 0 0 1 1 1 1 Small subunit of serine palmitoyltransferase-like RF-1 PF00472.20 EGD93369.1 - 8.7e-25 86.9 6.8 1.3e-24 86.4 6.8 1.2 1 0 0 1 1 1 1 RF-1 domain Cwf_Cwc_15 PF04889.12 EGD93369.1 - 0.015 15.0 4.8 0.018 14.8 4.8 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein XRN_M PF17846.1 EGD93369.1 - 0.3 10.0 2.2 0.37 9.7 2.2 1.0 1 0 0 1 1 1 0 Xrn1 helical domain CAS_CSE1 PF03378.15 EGD93370.1 - 3.4e-167 556.4 0.0 7.2e-167 555.4 0.0 1.6 1 0 0 1 1 1 1 CAS/CSE protein, C-terminus Cse1 PF08506.10 EGD93370.1 - 4.4e-157 522.6 3.9 6.4e-157 522.1 3.9 1.3 1 0 0 1 1 1 1 Cse1 IBN_N PF03810.19 EGD93370.1 - 1.1e-16 60.5 0.4 5.1e-16 58.4 0.2 2.4 2 0 0 2 2 2 1 Importin-beta N-terminal domain Xpo1 PF08389.12 EGD93370.1 - 0.023 14.7 1.0 1.7 8.7 0.0 4.1 3 1 0 3 3 3 0 Exportin 1-like protein V-ATPase_H_N PF03224.14 EGD93370.1 - 0.09 12.1 1.6 0.2 10.9 0.1 2.3 3 0 0 3 3 3 0 V-ATPase subunit H DUF3384 PF11864.8 EGD93371.1 - 7.1e-89 298.9 0.3 3.6e-88 296.6 0.1 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF3384) Tuberin PF03542.16 EGD93371.1 - 1e-40 139.9 2.1 8.9e-36 123.7 0.0 3.2 3 0 0 3 3 3 2 Tuberin CPSF100_C PF13299.6 EGD93371.1 - 1.3 9.2 4.5 11 6.1 2.8 2.4 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Presenilin PF01080.17 EGD93371.1 - 1.7 7.3 5.3 2.9 6.6 5.3 1.2 1 0 0 1 1 1 0 Presenilin PUF PF00806.19 EGD93372.1 - 8e-43 141.8 4.0 9.1e-07 28.2 0.0 6.7 6 0 0 6 6 6 6 Pumilio-family RNA binding repeat DUF5326 PF17260.2 EGD93374.1 - 0.052 13.7 0.1 0.078 13.1 0.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5326) Phosphodiest PF01663.22 EGD93375.1 - 9.2e-16 58.4 0.8 1.4e-15 57.7 0.8 1.3 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Metalloenzyme PF01676.18 EGD93375.1 - 7.5e-05 22.2 0.9 0.00013 21.5 0.9 1.2 1 0 0 1 1 1 1 Metalloenzyme superfamily Sulfatase PF00884.23 EGD93375.1 - 0.00039 19.9 0.0 0.00067 19.1 0.0 1.4 1 0 0 1 1 1 1 Sulfatase DUF2304 PF10066.9 EGD93375.1 - 0.42 10.8 2.4 18 5.6 0.4 2.9 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2304) cwf21 PF08312.12 EGD93376.1 - 1e-05 25.5 19.0 1e-05 25.5 19.0 2.4 2 1 0 2 2 2 1 cwf21 domain NRBF2 PF08961.10 EGD93376.1 - 0.022 14.4 4.0 0.022 14.4 4.0 1.8 2 0 0 2 2 2 0 Nuclear receptor-binding factor 2, autophagy regulator APG6_N PF17675.1 EGD93376.1 - 0.033 14.7 2.6 0.033 14.7 2.6 1.9 2 0 0 2 2 2 0 Apg6 coiled-coil region YabA PF06156.13 EGD93376.1 - 1.6 9.5 7.1 0.76 10.4 3.1 2.0 2 0 0 2 2 2 0 Initiation control protein YabA HA2 PF04408.23 EGD93377.1 - 7.7e-27 93.7 0.1 7.7e-27 93.7 0.1 2.7 2 0 0 2 2 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 EGD93377.1 - 3.7e-12 46.4 0.0 9.1e-12 45.2 0.0 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 EGD93377.1 - 4.4e-12 46.3 0.0 1.7e-11 44.4 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 EGD93377.1 - 4.8e-10 39.5 0.0 1.6e-08 34.5 0.0 2.4 2 0 0 2 2 2 1 DEAD/DEAH box helicase AAA_19 PF13245.6 EGD93377.1 - 0.0023 18.3 0.0 0.0045 17.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain ResIII PF04851.15 EGD93377.1 - 0.0031 17.5 1.5 2 8.4 0.0 2.8 3 0 0 3 3 3 2 Type III restriction enzyme, res subunit AAA_23 PF13476.6 EGD93377.1 - 0.0074 16.8 0.0 0.0074 16.8 0.0 3.6 4 0 0 4 4 3 1 AAA domain AAA_22 PF13401.6 EGD93377.1 - 0.0097 16.2 0.4 0.036 14.3 0.0 2.1 2 1 0 2 2 2 1 AAA domain AAA_30 PF13604.6 EGD93377.1 - 0.012 15.3 0.0 0.029 14.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain T2SSE PF00437.20 EGD93377.1 - 0.075 12.1 0.1 0.21 10.6 0.0 1.8 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_24 PF13479.6 EGD93377.1 - 0.082 12.6 0.0 0.21 11.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain FtsK_SpoIIIE PF01580.18 EGD93377.1 - 0.087 12.2 0.0 0.19 11.1 0.0 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family PAC3 PF10178.9 EGD93378.1 - 0.00017 21.6 0.0 0.00037 20.6 0.0 1.6 1 1 0 1 1 1 1 Proteasome assembly chaperone 3 TLP1_add_C PF18313.1 EGD93379.1 - 5.8e-24 83.9 0.3 2e-23 82.1 0.0 2.0 2 0 0 2 2 2 1 Thiolase-like protein type 1 additional C-terminal domain Cohesin_load PF10345.9 EGD93381.1 - 3.8e-165 550.8 5.6 4.6e-165 550.5 5.6 1.0 1 0 0 1 1 1 1 Cohesin loading factor Lactamase_B_4 PF13691.6 EGD93381.1 - 0.026 14.2 0.0 0.076 12.7 0.0 1.8 1 0 0 1 1 1 0 tRNase Z endonuclease EAP30 PF04157.16 EGD93381.1 - 0.049 12.9 0.0 0.15 11.3 0.0 1.9 1 1 0 1 1 1 0 EAP30/Vps36 family TPR_4 PF07721.14 EGD93381.1 - 1.2 10.0 5.5 18 6.3 0.1 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.6 EGD93381.1 - 1.7 9.0 19.0 3.5 8.0 0.8 5.8 6 0 0 6 6 6 0 Tetratricopeptide repeat Histone PF00125.24 EGD93382.1 - 1.3e-41 142.0 0.3 1.8e-41 141.5 0.2 1.2 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 EGD93382.1 - 5.8e-05 23.2 0.0 0.0001 22.4 0.0 1.3 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 EGD93382.1 - 0.00045 20.6 0.0 0.00066 20.0 0.0 1.3 1 0 0 1 1 1 1 CENP-S protein CBFD_NFYB_HMF PF00808.23 EGD93382.1 - 0.0063 16.8 0.3 0.012 15.8 0.3 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 EGD93382.1 - 0.1 12.6 0.0 0.15 12.1 0.0 1.2 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit DER1 PF04511.15 EGD93383.1 - 1.6e-47 161.9 5.7 1.9e-47 161.7 5.7 1.0 1 0 0 1 1 1 1 Der1-like family Serpentine_r_xa PF03383.15 EGD93383.1 - 0.068 13.1 1.8 0.12 12.4 1.8 1.4 1 0 0 1 1 1 0 Caenorhabditis serpentine receptor-like protein, class xa EMP70 PF02990.16 EGD93384.1 - 1.1e-155 519.2 11.5 1.1e-76 258.7 24.5 2.2 1 1 1 2 2 2 2 Endomembrane protein 70 ubiquitin PF00240.23 EGD93385.1 - 4e-19 68.1 0.0 6.9e-19 67.4 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family UBA PF00627.31 EGD93385.1 - 7.4e-08 32.2 0.1 1.8e-07 30.9 0.1 1.7 1 0 0 1 1 1 1 UBA/TS-N domain Rad60-SLD PF11976.8 EGD93385.1 - 2.1e-05 24.2 0.0 3.6e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 EGD93385.1 - 0.00029 21.4 1.5 0.00047 20.7 0.0 2.0 3 0 0 3 3 3 1 DUF2407 ubiquitin-like domain Rad60-SLD_2 PF13881.6 EGD93385.1 - 0.0011 19.1 0.0 0.0026 17.9 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like STI1 PF17830.1 EGD93385.1 - 0.015 15.2 1.1 0.015 15.2 1.1 3.0 2 1 1 3 3 3 0 STI1 domain HOIP-UBA PF16678.5 EGD93385.1 - 0.074 13.1 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 HOIP UBA domain pair GerD PF17898.1 EGD93385.1 - 0.3 11.1 5.1 0.66 9.9 4.3 1.9 1 1 1 2 2 2 0 Spore germination GerD central core domain Corazonin PF17308.2 EGD93385.1 - 0.33 11.3 8.2 0.4 11.1 0.3 3.0 4 0 0 4 4 4 0 Pro-corazonin MMS1_N PF10433.9 EGD93386.1 - 4.8e-135 450.9 0.0 1.2e-134 449.7 0.0 1.7 1 1 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.15 EGD93386.1 - 3.4e-102 342.0 0.0 7.1e-101 337.7 0.0 2.7 3 0 0 3 3 3 1 CPSF A subunit region ANAPC4_WD40 PF12894.7 EGD93386.1 - 0.043 14.1 0.0 1.5 9.2 0.0 3.4 3 1 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain CN_hydrolase PF00795.22 EGD93387.1 - 1.1e-31 110.1 0.0 1.5e-31 109.7 0.0 1.1 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase BP28CT PF08146.12 EGD93388.1 - 9.1e-43 145.8 0.2 4.5e-42 143.6 0.2 2.3 1 0 0 1 1 1 1 BP28CT (NUC211) domain U3snoRNP10 PF12397.8 EGD93388.1 - 7e-25 87.6 0.8 7e-25 87.6 0.8 5.2 6 0 0 6 6 6 1 U3 small nucleolar RNA-associated protein 10 HEAT_2 PF13646.6 EGD93388.1 - 3.1e-05 24.3 6.7 0.54 10.7 0.1 7.0 5 3 1 6 6 6 1 HEAT repeats Adaptin_N PF01602.20 EGD93388.1 - 0.0022 16.7 9.3 0.0024 16.5 0.3 4.2 4 1 0 4 4 4 1 Adaptin N terminal region Nipped-B_C PF12830.7 EGD93388.1 - 0.27 11.1 4.9 30 4.5 0.0 4.8 5 0 0 5 5 5 0 Sister chromatid cohesion C-terminus HEAT PF02985.22 EGD93388.1 - 1.3 9.4 13.5 1.2 9.5 0.0 7.0 9 0 0 9 9 9 0 HEAT repeat NRDE-2 PF08424.10 EGD93389.1 - 7.3e-94 314.5 0.0 2.5e-92 309.4 0.0 2.7 3 0 0 3 3 3 1 NRDE-2, necessary for RNA interference TPR_14 PF13428.6 EGD93389.1 - 0.00061 20.4 2.1 8.4 7.5 0.0 5.6 5 1 1 6 6 6 1 Tetratricopeptide repeat TPR_17 PF13431.6 EGD93389.1 - 0.18 12.2 0.2 1.4 9.5 0.2 2.6 1 0 0 1 1 1 0 Tetratricopeptide repeat UDG PF03167.19 EGD93390.1 - 5.2e-19 68.8 0.0 5.5e-18 65.4 0.0 2.1 2 0 0 2 2 2 1 Uracil DNA glycosylase superfamily 7TMR-DISM_7TM PF07695.11 EGD93391.1 - 0.38 10.6 8.5 1.1 9.1 8.5 1.7 1 1 0 1 1 1 0 7TM diverse intracellular signalling NAD_binding_6 PF08030.12 EGD93393.1 - 1.2e-23 83.9 0.0 2.1e-23 83.2 0.0 1.4 1 0 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 EGD93393.1 - 1.1e-22 80.2 0.0 2.4e-22 79.1 0.0 1.5 1 0 0 1 1 1 1 FAD-binding domain Ferric_reduct PF01794.19 EGD93393.1 - 7.1e-21 74.6 9.4 1.4e-20 73.6 9.4 1.6 1 0 0 1 1 1 1 Ferric reductase like transmembrane component NAD_binding_1 PF00175.21 EGD93393.1 - 0.043 14.5 0.0 5 7.8 0.0 2.4 2 0 0 2 2 2 0 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 EGD93393.1 - 0.043 14.2 0.0 0.087 13.2 0.0 1.5 1 0 0 1 1 1 0 Oxidoreductase FAD-binding domain SBDS PF01172.18 EGD93394.1 - 1.4e-25 89.1 0.1 1.7e-25 88.9 0.1 1.1 1 0 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein RhoGEF PF00621.20 EGD93395.1 - 1.1e-22 81.2 0.0 2e-22 80.3 0.0 1.5 1 0 0 1 1 1 1 RhoGEF domain Nas2_N PF18265.1 EGD93396.1 - 1.3e-27 95.6 0.1 1.8e-27 95.0 0.1 1.3 1 0 0 1 1 1 1 Nas2 N_terminal domain PDZ_2 PF13180.6 EGD93396.1 - 1e-05 25.8 0.0 2.1e-05 24.7 0.0 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 EGD93396.1 - 2.7e-05 23.9 0.0 5.7e-05 22.9 0.0 1.6 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 EGD93396.1 - 0.002 18.4 0.0 0.0039 17.5 0.0 1.4 1 0 0 1 1 1 1 PDZ domain Ras PF00071.22 EGD93397.1 - 1.6e-49 167.6 0.0 1.9e-49 167.4 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EGD93397.1 - 1.3e-29 102.9 0.1 3.1e-29 101.6 0.0 1.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EGD93397.1 - 4.2e-11 42.6 0.0 6.3e-11 42.0 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family RNA_helicase PF00910.22 EGD93397.1 - 0.0003 21.1 0.1 0.0017 18.7 0.1 2.0 1 1 0 1 1 1 1 RNA helicase Gtr1_RagA PF04670.12 EGD93397.1 - 0.00061 19.2 0.0 0.0008 18.8 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EGD93397.1 - 0.00088 19.3 0.0 0.0018 18.3 0.0 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase G-alpha PF00503.20 EGD93397.1 - 0.0059 15.8 1.6 1.8 7.6 0.1 2.9 2 1 1 3 3 3 2 G-protein alpha subunit Pox_A32 PF04665.12 EGD93397.1 - 0.021 14.3 0.1 0.041 13.3 0.1 1.4 1 0 0 1 1 1 0 Poxvirus A32 protein RsgA_GTPase PF03193.16 EGD93397.1 - 0.031 14.2 0.0 7.3 6.5 0.0 2.2 2 0 0 2 2 2 0 RsgA GTPase AAA_7 PF12775.7 EGD93397.1 - 0.034 13.7 0.1 0.057 12.9 0.1 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_24 PF13479.6 EGD93397.1 - 0.042 13.6 0.2 0.055 13.2 0.2 1.4 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EGD93397.1 - 0.074 13.4 0.0 0.12 12.8 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain TsaE PF02367.17 EGD93397.1 - 0.083 12.9 0.0 0.22 11.6 0.0 1.7 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE SRPRB PF09439.10 EGD93397.1 - 0.1 12.0 0.0 0.17 11.3 0.0 1.4 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_33 PF13671.6 EGD93397.1 - 0.11 12.6 0.2 0.22 11.7 0.2 1.5 1 0 0 1 1 1 0 AAA domain Septin PF00735.18 EGD93397.1 - 0.15 11.3 0.3 0.23 10.7 0.0 1.5 2 0 0 2 2 2 0 Septin SNF2_N PF00176.23 EGD93398.1 - 1e-60 205.4 0.4 2.2e-60 204.2 0.4 1.6 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EGD93398.1 - 2.3e-14 53.7 0.0 5.7e-14 52.4 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-C3HC4_2 PF13923.6 EGD93398.1 - 3.2e-08 33.3 1.8 3.2e-08 33.3 1.8 1.8 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EGD93398.1 - 7e-08 32.2 2.8 1.4e-07 31.3 2.8 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EGD93398.1 - 3.8e-06 26.7 3.5 7.8e-06 25.7 3.5 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) ResIII PF04851.15 EGD93398.1 - 1e-05 25.6 0.0 2.2e-05 24.5 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit zf-RING_2 PF13639.6 EGD93398.1 - 3.7e-05 24.0 3.8 8.2e-05 22.9 3.8 1.6 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 EGD93398.1 - 5.4e-05 23.1 3.5 0.00012 22.0 3.5 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EGD93398.1 - 6.5e-05 22.9 2.0 0.00014 21.8 2.0 1.6 1 0 0 1 1 1 1 RING-type zinc-finger Prok-RING_4 PF14447.6 EGD93398.1 - 0.0013 18.6 4.1 0.0042 16.9 4.1 1.9 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_4 PF14570.6 EGD93398.1 - 0.002 17.9 3.5 0.0044 16.8 3.5 1.7 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-C3HC4_4 PF15227.6 EGD93398.1 - 0.015 15.5 5.4 0.031 14.4 5.4 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING DZR PF12773.7 EGD93398.1 - 0.045 13.8 3.7 0.11 12.5 3.8 1.6 1 1 0 1 1 1 0 Double zinc ribbon CCDC50_N PF15295.6 EGD93398.1 - 0.72 10.0 7.7 2 8.6 7.7 1.7 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 50 N-terminus DUF1644 PF07800.12 EGD93398.1 - 1.7 8.7 4.9 26 4.8 2.0 2.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1644) SPT6_acidic PF14632.6 EGD93398.1 - 9.9 6.8 18.0 0.63 10.7 6.5 2.6 2 0 0 2 2 2 0 Acidic N-terminal SPT6 F-box-like PF12937.7 EGD93399.1 - 0.00026 20.8 0.1 0.12 12.3 0.0 2.5 2 0 0 2 2 2 2 F-box-like F-box PF00646.33 EGD93399.1 - 0.12 12.3 1.2 5.5 7.0 0.0 2.5 2 0 0 2 2 2 0 F-box domain Ran_BP1 PF00638.18 EGD93400.1 - 6.5e-14 52.2 0.0 1.3e-13 51.2 0.0 1.5 1 0 0 1 1 1 1 RanBP1 domain Nucleoporin_FG PF13634.6 EGD93400.1 - 0.0014 19.4 44.1 0.004 18.0 20.7 11.3 3 3 7 10 10 10 5 Nucleoporin FG repeat region WH1 PF00568.23 EGD93400.1 - 0.11 12.4 0.0 0.21 11.5 0.0 1.3 1 0 0 1 1 1 0 WH1 domain TRAP_alpha PF03896.16 EGD93400.1 - 5.3 6.2 5.5 11 5.1 5.5 1.6 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit CN_hydrolase PF00795.22 EGD93401.1 - 5.2e-58 196.4 0.0 6.1e-58 196.2 0.0 1.1 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase Ribosomal_L31e PF01198.19 EGD93401.1 - 3.3e-30 104.2 0.1 5.7e-30 103.4 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L31e Fungal_trans PF04082.18 EGD93402.1 - 5.7e-09 35.4 2.6 8.8e-09 34.8 2.6 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EGD93402.1 - 3.6e-06 27.0 8.0 6.6e-06 26.1 8.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF885 PF05960.11 EGD93402.1 - 0.095 12.3 0.0 0.15 11.7 0.0 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF885) FAD_binding_3 PF01494.19 EGD93403.1 - 4.3e-32 111.7 0.1 5.6e-32 111.3 0.1 1.1 1 0 0 1 1 1 1 FAD binding domain Trp_halogenase PF04820.14 EGD93403.1 - 6.5e-08 31.9 1.4 2.6e-05 23.3 0.1 2.4 1 1 1 2 2 2 2 Tryptophan halogenase Pyr_redox_2 PF07992.14 EGD93403.1 - 9.8e-06 25.0 0.2 0.012 14.9 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EGD93403.1 - 8.6e-05 21.7 0.1 0.00017 20.7 0.1 1.4 1 1 0 1 1 1 1 Lycopene cyclase protein NAD_binding_8 PF13450.6 EGD93403.1 - 0.0018 18.4 0.5 0.0056 16.9 0.1 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 EGD93403.1 - 0.0068 16.9 0.0 0.016 15.7 0.0 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EGD93403.1 - 0.038 13.2 0.1 0.091 12.0 0.1 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EGD93403.1 - 1 8.9 3.8 1.2 8.6 1.1 1.9 1 1 0 2 2 2 0 FAD dependent oxidoreductase Thioesterase PF00975.20 EGD93404.1 - 3.8e-19 69.7 0.1 6.8e-19 68.9 0.0 1.4 1 1 0 1 1 1 1 Thioesterase domain Abhydrolase_1 PF00561.20 EGD93404.1 - 7.1e-07 29.1 0.0 9.7e-07 28.7 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EGD93404.1 - 4.5e-05 24.1 0.0 4.5e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Pyr_redox PF00070.27 EGD93404.1 - 0.055 14.0 0.0 0.14 12.8 0.0 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EGD93404.1 - 0.059 12.6 0.0 0.1 11.8 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Abhydrolase_5 PF12695.7 EGD93404.1 - 0.12 12.1 0.0 0.69 9.7 0.0 2.0 2 0 0 2 2 2 0 Alpha/beta hydrolase family Asp PF00026.23 EGD93405.1 - 6.8e-13 48.7 0.6 3.8e-08 33.1 0.0 2.2 2 0 0 2 2 2 2 Eukaryotic aspartyl protease TAXi_C PF14541.6 EGD93405.1 - 0.025 14.4 0.0 0.044 13.5 0.0 1.4 1 0 0 1 1 1 0 Xylanase inhibitor C-terminal p450 PF00067.22 EGD93406.1 - 3.3e-51 174.5 0.0 5.4e-51 173.8 0.0 1.3 1 0 0 1 1 1 1 Cytochrome P450 DUF2953 PF11167.8 EGD93406.1 - 0.12 12.5 0.1 0.41 10.7 0.1 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2953) AMP-binding PF00501.28 EGD93407.1 - 7.5e-80 268.6 0.0 1.2e-79 268.0 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme Condensation PF00668.20 EGD93407.1 - 3e-77 260.3 0.0 4.7e-77 259.6 0.0 1.2 1 0 0 1 1 1 1 Condensation domain ketoacyl-synt PF00109.26 EGD93407.1 - 5.4e-73 245.7 0.0 1.1e-72 244.6 0.0 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain PS-DH PF14765.6 EGD93407.1 - 4.6e-61 206.6 0.0 7.2e-61 206.0 0.0 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase KR PF08659.10 EGD93407.1 - 8.2e-60 201.8 0.2 3.4e-59 199.8 0.0 2.3 2 0 0 2 2 2 1 KR domain Acyl_transf_1 PF00698.21 EGD93407.1 - 3.9e-57 194.2 0.0 6.9e-57 193.3 0.0 1.4 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 EGD93407.1 - 3.2e-40 136.8 0.1 1.7e-39 134.5 0.1 2.2 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain NAD_binding_4 PF07993.12 EGD93407.1 - 2.9e-36 125.0 0.0 6.3e-36 123.9 0.0 1.6 1 0 0 1 1 1 1 Male sterility protein KAsynt_C_assoc PF16197.5 EGD93407.1 - 1.6e-22 80.1 0.0 7.4e-22 77.9 0.0 2.2 2 0 0 2 2 2 1 Ketoacyl-synthetase C-terminal extension PP-binding PF00550.25 EGD93407.1 - 1.1e-20 73.7 0.2 1.7e-10 41.1 0.0 2.9 2 0 0 2 2 2 2 Phosphopantetheine attachment site ADH_zinc_N PF00107.26 EGD93407.1 - 8.3e-18 64.6 0.0 4.9e-17 62.1 0.0 2.4 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EGD93407.1 - 5.3e-16 59.9 0.0 1.2e-14 55.5 0.0 3.2 4 0 0 4 4 2 1 Zinc-binding dehydrogenase adh_short PF00106.25 EGD93407.1 - 9.6e-09 35.0 0.4 2.6e-08 33.6 0.0 1.9 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 EGD93407.1 - 3.7e-06 26.7 0.0 8.2e-06 25.5 0.0 1.5 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Thiolase_N PF00108.23 EGD93407.1 - 0.00084 18.8 0.0 0.0024 17.3 0.0 1.7 1 0 0 1 1 1 1 Thiolase, N-terminal domain AMP-binding_C PF13193.6 EGD93407.1 - 0.0037 18.2 0.0 0.0096 16.9 0.0 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain DUF1233 PF06806.12 EGD93407.1 - 0.088 12.4 0.0 0.22 11.1 0.0 1.6 1 0 0 1 1 1 0 Putative excisionase (DUF1233) ATG2_CAD PF13329.6 EGD93411.1 - 2.1e-44 151.0 0.2 5e-44 149.7 0.2 1.7 1 0 0 1 1 1 1 Autophagy-related protein 2 CAD motif ATG_C PF09333.11 EGD93411.1 - 1.4e-25 89.4 0.4 4.6e-25 87.8 0.1 2.0 2 0 0 2 2 2 1 Autophagy-related protein C terminal domain VPS13_C PF16909.5 EGD93411.1 - 0.0022 17.8 0.0 0.0098 15.7 0.0 2.0 2 0 0 2 2 2 1 Vacuolar-sorting-associated 13 protein C-terminal A_deaminase PF00962.22 EGD93412.1 - 4.2e-21 75.6 0.0 9.2e-21 74.5 0.0 1.6 2 0 0 2 2 2 1 Adenosine/AMP deaminase Mt_ATP-synt_B PF05405.14 EGD93412.1 - 0.067 12.8 1.3 0.12 12.0 1.3 1.3 1 0 0 1 1 1 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) Ribosomal_S17 PF00366.20 EGD93413.1 - 1.6e-13 50.5 0.7 2.7e-13 49.8 0.7 1.4 1 0 0 1 1 1 1 Ribosomal protein S17 DUF737 PF05300.11 EGD93413.1 - 0.058 13.7 2.4 0.84 10.0 2.3 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF737) AAA PF00004.29 EGD93414.1 - 1.3e-36 125.9 0.0 2.2e-36 125.2 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.10 EGD93414.1 - 2.1e-11 43.7 0.0 1.1e-07 31.7 0.0 3.5 3 0 0 3 3 3 2 Vps4 C terminal oligomerisation domain AAA_lid_3 PF17862.1 EGD93414.1 - 1.6e-08 34.2 0.0 4.3e-08 32.8 0.0 1.8 1 0 0 1 1 1 1 AAA+ lid domain AAA_22 PF13401.6 EGD93414.1 - 5.7e-05 23.4 0.1 0.00042 20.6 0.1 2.3 1 1 0 1 1 1 1 AAA domain AAA_2 PF07724.14 EGD93414.1 - 9.6e-05 22.6 0.0 0.00016 21.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 EGD93414.1 - 0.00012 21.8 0.0 0.00023 20.9 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EGD93414.1 - 0.00022 21.7 1.4 0.0052 17.2 0.1 3.2 3 1 0 3 3 3 1 AAA ATPase domain AAA_5 PF07728.14 EGD93414.1 - 0.002 18.1 0.1 0.01 15.8 0.0 2.3 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) TIP49 PF06068.13 EGD93414.1 - 0.0036 16.6 0.0 0.0072 15.6 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain Mg_chelatase PF01078.21 EGD93414.1 - 0.0061 16.0 0.0 0.013 14.9 0.0 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 EGD93414.1 - 0.0091 15.7 0.0 0.018 14.8 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein DUF815 PF05673.13 EGD93414.1 - 0.032 13.4 0.0 0.054 12.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_18 PF13238.6 EGD93414.1 - 0.061 13.9 0.0 0.18 12.4 0.0 1.8 1 1 0 1 1 1 0 AAA domain TniB PF05621.11 EGD93414.1 - 0.068 12.6 0.0 2.2 7.6 0.0 2.3 1 1 1 2 2 2 0 Bacterial TniB protein AAA_7 PF12775.7 EGD93414.1 - 0.079 12.5 0.0 0.15 11.5 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_33 PF13671.6 EGD93414.1 - 0.09 12.9 0.0 0.18 11.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.6 EGD93414.1 - 0.096 12.7 0.0 0.21 11.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 EGD93414.1 - 0.11 12.2 0.0 0.22 11.2 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_25 PF13481.6 EGD93414.1 - 0.11 12.0 0.0 0.37 10.3 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 EGD93414.1 - 0.19 12.0 0.5 2.3 8.5 0.0 2.6 3 0 0 3 3 3 0 AAA domain Sde2_N_Ubi PF13019.6 EGD93415.1 - 9.5e-67 223.9 0.1 2.5e-66 222.5 0.1 1.8 2 0 0 2 2 2 1 Silencing defective 2 N-terminal ubiquitin domain MMR_HSR1 PF01926.23 EGD93415.1 - 0.00014 21.9 0.4 0.32 11.1 0.2 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase S10_plectin PF03501.15 EGD93416.1 - 7.3e-41 138.2 0.1 8.8e-41 137.9 0.1 1.1 1 0 0 1 1 1 1 Plectin/S10 domain Peptidase_M20 PF01546.28 EGD93417.1 - 1.1e-28 100.4 0.2 1.5e-28 99.9 0.2 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 EGD93417.1 - 6.3e-06 26.1 0.0 1.6e-05 24.8 0.0 1.7 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 EGD93417.1 - 0.007 16.1 0.0 0.013 15.2 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M28 HIT PF01230.23 EGD93418.1 - 4.5e-22 78.6 0.1 5.7e-22 78.3 0.1 1.1 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.8 EGD93418.1 - 5.3e-12 46.2 0.0 8.2e-12 45.6 0.0 1.3 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding CwfJ_C_1 PF04677.15 EGD93418.1 - 0.0046 16.8 0.0 0.0086 15.9 0.0 1.4 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 CRAL_TRIO PF00650.20 EGD93419.1 - 2.7e-38 131.2 0.0 5.7e-38 130.1 0.0 1.6 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 EGD93419.1 - 6.5e-14 51.9 0.1 2e-13 50.3 0.1 1.9 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.6 EGD93419.1 - 2.6e-06 27.6 0.0 4.5e-06 26.9 0.0 1.4 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain DUF755 PF05501.11 EGD93419.1 - 0.037 14.3 1.4 0.037 14.3 1.4 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF755) DASH_Dam1 PF08653.10 EGD93420.1 - 7.6e-30 102.5 2.1 1.1e-29 102.0 2.1 1.2 1 0 0 1 1 1 1 DASH complex subunit Dam1 Aminopep PF10023.9 EGD93420.1 - 0.12 11.7 0.6 0.16 11.3 0.6 1.1 1 0 0 1 1 1 0 Putative aminopeptidase UCH PF00443.29 EGD93422.1 - 7.6e-53 179.6 0.1 1e-52 179.2 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EGD93422.1 - 1.1e-23 84.3 3.1 7.6e-23 81.6 3.1 2.0 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 EGD93422.1 - 0.00012 22.4 0.7 0.00012 22.4 0.7 2.6 3 0 0 3 3 3 1 Zn-finger in ubiquitin-hydrolases and other protein APH PF01636.23 EGD93423.1 - 2.1e-09 37.7 0.0 3.4e-09 37.0 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family DUF4091 PF13320.6 EGD93423.1 - 0.051 13.7 0.3 0.1 12.8 0.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4091) Choline_kinase PF01633.20 EGD93423.1 - 0.15 11.6 0.0 0.24 11.0 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase EcKinase PF02958.20 EGD93423.1 - 0.23 10.8 0.0 0.35 10.1 0.0 1.3 1 0 0 1 1 1 0 Ecdysteroid kinase Abhydrolase_2 PF02230.16 EGD93424.1 - 2.3e-18 66.8 0.0 1.8e-14 54.0 0.0 2.1 1 1 1 2 2 2 2 Phospholipase/Carboxylesterase FSH1 PF03959.13 EGD93424.1 - 0.006 16.3 0.0 0.027 14.1 0.0 1.8 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Hydrolase_4 PF12146.8 EGD93424.1 - 0.038 13.3 0.5 0.084 12.1 0.0 1.8 3 0 0 3 3 3 0 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 EGD93424.1 - 0.17 11.3 0.0 0.29 10.6 0.0 1.3 1 0 0 1 1 1 0 Prolyl oligopeptidase family Rhomboid PF01694.22 EGD93425.1 - 2.6e-13 50.3 8.8 4.6e-13 49.4 8.8 1.3 1 0 0 1 1 1 1 Rhomboid family Ytp1 PF10355.9 EGD93426.1 - 1.8e-117 391.5 6.4 1.8e-117 391.5 6.4 1.7 2 1 0 2 2 2 1 Protein of unknown function (Ytp1) DUF2427 PF10348.9 EGD93426.1 - 1.7e-27 95.2 8.1 1.7e-27 95.2 8.1 3.2 4 0 0 4 4 4 2 Domain of unknown function (DUF2427) DUF1440 PF07274.12 EGD93426.1 - 0.14 12.5 2.7 0.19 12.1 0.1 2.4 2 1 1 3 3 3 0 Protein of unknown function (DUF1440) RTA1 PF04479.13 EGD93427.1 - 1.1e-68 230.9 0.2 1.1e-68 230.9 0.2 1.5 2 0 0 2 2 2 1 RTA1 like protein Pex24p PF06398.11 EGD93427.1 - 0.67 8.9 2.8 0.93 8.4 1.4 1.9 2 1 1 3 3 3 0 Integral peroxisomal membrane peroxin PhrC_PhrF PF11131.8 EGD93427.1 - 3.9 7.2 5.4 13 5.5 1.0 2.5 2 0 0 2 2 2 0 Rap-phr extracellular signalling DndE PF08870.11 EGD93428.1 - 0.044 14.0 0.0 2.5 8.4 0.0 2.2 2 0 0 2 2 2 0 DNA sulphur modification protein DndE Gaa1 PF04114.14 EGD93429.1 - 5e-180 599.8 5.5 6.1e-180 599.5 5.5 1.1 1 0 0 1 1 1 1 Gaa1-like, GPI transamidase component PCI PF01399.27 EGD93430.1 - 6e-10 39.6 0.1 1.3e-09 38.5 0.1 1.6 1 0 0 1 1 1 1 PCI domain Rpn9_C PF18261.1 EGD93430.1 - 0.00027 20.5 0.1 0.00051 19.6 0.1 1.4 1 0 0 1 1 1 1 Rpn9 C-terminal helix Methyltransf_23 PF13489.6 EGD93431.1 - 3e-13 49.9 0.0 3.8e-13 49.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EGD93431.1 - 2.1e-12 47.6 0.0 5e-12 46.4 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EGD93431.1 - 2.5e-12 46.8 0.0 3.2e-12 46.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EGD93431.1 - 5.9e-12 46.1 0.0 1.3e-11 45.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EGD93431.1 - 2.9e-11 43.9 0.0 1.1e-10 42.1 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EGD93431.1 - 3.9e-07 29.6 0.0 7.3e-07 28.8 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_15 PF09445.10 EGD93431.1 - 0.029 14.0 0.0 0.037 13.6 0.0 1.1 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase DREV PF05219.12 EGD93431.1 - 0.036 13.2 0.0 0.053 12.6 0.0 1.2 1 0 0 1 1 1 0 DREV methyltransferase Methyltransf_32 PF13679.6 EGD93431.1 - 0.038 14.0 0.0 0.053 13.5 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain GMC_oxred_N PF00732.19 EGD93432.1 - 4.3e-62 210.1 0.0 6e-62 209.7 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EGD93432.1 - 5.3e-36 124.3 0.0 8.2e-36 123.7 0.0 1.3 1 0 0 1 1 1 1 GMC oxidoreductase DAO PF01266.24 EGD93432.1 - 1.1e-07 31.8 0.1 0.0039 16.8 0.0 3.2 3 1 0 3 3 3 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EGD93432.1 - 5.4e-07 29.0 0.0 0.0095 15.1 0.0 2.2 2 0 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.6 EGD93432.1 - 0.0003 21.0 0.0 0.00098 19.3 0.0 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 EGD93432.1 - 0.00085 18.6 0.2 0.009 15.3 0.0 2.0 2 0 0 2 2 2 1 Thi4 family Lycopene_cycl PF05834.12 EGD93432.1 - 0.0014 17.8 0.1 0.002 17.2 0.1 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein Pyr_redox_2 PF07992.14 EGD93432.1 - 0.034 13.4 0.1 3.2 6.9 0.0 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EGD93432.1 - 0.11 11.2 0.0 1.2 7.7 0.0 2.0 2 0 0 2 2 2 0 HI0933-like protein Pyr_redox PF00070.27 EGD93432.1 - 0.17 12.5 0.1 37 5.0 0.0 2.4 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase DUF1242 PF06842.12 EGD93434.1 - 0.037 13.8 0.5 0.037 13.8 0.5 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1242) Epimerase PF01370.21 EGD93435.1 - 2.2e-14 53.5 0.1 6.7e-14 51.9 0.0 1.8 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 EGD93435.1 - 5.9e-12 45.8 0.0 1.1e-11 45.0 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 EGD93435.1 - 2.1e-11 43.8 0.0 3.1e-11 43.3 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family 3Beta_HSD PF01073.19 EGD93435.1 - 2.5e-11 43.1 0.1 4.3e-11 42.4 0.1 1.4 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 EGD93435.1 - 2.6e-07 30.4 0.4 7.4e-07 28.9 0.1 1.7 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase adh_short PF00106.25 EGD93435.1 - 0.00013 21.5 0.0 0.00023 20.7 0.0 1.4 1 0 0 1 1 1 1 short chain dehydrogenase NAD_binding_4 PF07993.12 EGD93435.1 - 0.00014 21.1 0.2 0.012 14.8 0.1 2.8 1 1 1 2 2 2 1 Male sterility protein RmlD_sub_bind PF04321.17 EGD93435.1 - 0.00071 18.8 0.0 0.061 12.4 0.0 2.4 1 1 0 1 1 1 1 RmlD substrate binding domain adh_short_C2 PF13561.6 EGD93435.1 - 0.004 16.7 0.0 0.0073 15.9 0.0 1.4 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase HIM1 PF08732.10 EGD93435.1 - 0.028 14.0 0.0 0.043 13.3 0.0 1.3 1 0 0 1 1 1 0 HIM1 DDE_Tnp_1_3 PF13612.6 EGD93435.1 - 0.11 12.5 0.0 0.42 10.6 0.0 1.8 2 0 0 2 2 2 0 Transposase DDE domain KR PF08659.10 EGD93435.1 - 0.17 11.8 0.0 2.4 8.0 0.0 2.3 3 0 0 3 3 3 0 KR domain fn3 PF00041.21 EGD93437.1 - 0.078 13.3 0.4 0.13 12.6 0.4 1.3 1 0 0 1 1 1 0 Fibronectin type III domain Pkinase PF00069.25 EGD93438.1 - 1e-24 87.3 0.0 2e-23 83.1 0.0 2.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD93438.1 - 1.4e-14 54.0 0.0 5.7e-12 45.5 0.0 2.8 1 1 0 1 1 1 1 Protein tyrosine kinase Nt_Gln_amidase PF09764.9 EGD93438.1 - 0.056 13.1 0.0 0.094 12.3 0.0 1.3 1 0 0 1 1 1 0 N-terminal glutamine amidase HEM4 PF02602.15 EGD93439.1 - 1.3e-36 126.1 0.0 1.8e-36 125.6 0.0 1.1 1 0 0 1 1 1 1 Uroporphyrinogen-III synthase HemD Pkinase PF00069.25 EGD93440.1 - 1.3e-67 228.0 0.0 1.5e-67 227.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD93440.1 - 8.5e-32 110.4 0.0 1.1e-31 110.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EGD93440.1 - 0.00054 19.4 0.2 0.0009 18.7 0.2 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 EGD93440.1 - 0.002 17.1 0.1 0.0031 16.5 0.1 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 EGD93440.1 - 0.0097 15.2 0.0 0.018 14.4 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 EGD93440.1 - 0.03 14.3 0.2 0.086 12.7 0.2 1.5 1 1 0 1 1 1 0 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 EGD93440.1 - 0.078 12.0 0.0 0.12 11.4 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 S_100 PF01023.19 EGD93440.1 - 0.15 11.8 0.8 0.45 10.3 0.8 1.8 1 0 0 1 1 1 0 S-100/ICaBP type calcium binding domain Sec23_trunk PF04811.15 EGD93441.1 - 9e-72 241.5 0.0 1.9e-71 240.5 0.0 1.5 2 0 0 2 2 2 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.15 EGD93441.1 - 5.7e-22 77.5 0.0 2e-21 75.7 0.0 2.0 2 0 0 2 2 2 1 Sec23/Sec24 helical domain Sec23_BS PF08033.12 EGD93441.1 - 8.7e-17 61.7 0.0 1.9e-16 60.6 0.0 1.6 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.15 EGD93441.1 - 2.5e-16 59.4 3.7 4.6e-16 58.6 3.7 1.5 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 EGD93441.1 - 2e-06 27.6 0.0 3.8e-06 26.7 0.0 1.5 1 0 0 1 1 1 1 Gelsolin repeat Vps36-NZF-N PF16988.5 EGD93441.1 - 0.011 15.1 0.0 0.022 14.1 0.0 1.4 1 0 0 1 1 1 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain Kinesin PF00225.23 EGD93442.1 - 1.3e-79 267.6 0.2 1.9e-79 267.1 0.2 1.3 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EGD93442.1 - 1.7e-17 63.8 0.0 3.3e-17 62.8 0.0 1.5 1 0 0 1 1 1 1 Microtubule binding HHH PF00633.23 EGD93442.1 - 0.0077 16.0 0.1 2.6 8.1 0.0 2.8 2 0 0 2 2 2 2 Helix-hairpin-helix motif TPR_14 PF13428.6 EGD93442.1 - 0.18 12.7 0.3 0.79 10.7 0.2 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat MFS_1 PF07690.16 EGD93443.1 - 3.3e-24 85.5 46.9 7.1e-17 61.3 21.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily bZIP_1 PF00170.21 EGD93444.1 - 0.033 14.3 4.7 0.074 13.2 4.7 1.6 1 0 0 1 1 1 0 bZIP transcription factor NICE-3 PF07406.11 EGD93444.1 - 0.063 13.3 1.1 0.13 12.3 1.1 1.4 1 0 0 1 1 1 0 NICE-3 protein DUF5393 PF17371.2 EGD93444.1 - 0.085 11.0 0.1 0.085 11.0 0.1 2.1 1 1 0 2 2 2 0 Family of unknown function (DUF5393) TSC22 PF01166.18 EGD93444.1 - 0.29 11.5 4.3 6.2 7.2 0.1 2.9 1 1 2 3 3 3 0 TSC-22/dip/bun family TRAF_BIRC3_bd PF16673.5 EGD93444.1 - 1.5 8.7 5.8 0.68 9.8 2.6 2.1 2 0 0 2 2 2 0 TNF receptor-associated factor BIRC3 binding domain Med9 PF07544.13 EGD93444.1 - 3.5 7.8 7.4 3.2 7.9 1.7 2.8 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 Chromate_transp PF02417.15 EGD93445.1 - 3.6e-61 205.9 35.5 7.9e-32 110.6 14.3 2.3 2 0 0 2 2 2 2 Chromate transporter Ndc1_Nup PF09531.10 EGD93445.1 - 5.6 5.5 5.1 13 4.3 4.6 1.8 1 1 0 1 1 1 0 Nucleoporin protein Ndc1-Nup HRI1 PF16815.5 EGD93446.1 - 2.3e-26 92.9 0.1 3.4e-26 92.4 0.1 1.4 1 1 0 1 1 1 1 Protein HRI1 YebF PF13995.6 EGD93446.1 - 0.035 14.1 0.0 0.062 13.3 0.0 1.3 1 0 0 1 1 1 0 YebF-like protein Peptidase_M43 PF05572.13 EGD93447.1 - 2.1e-15 57.0 0.6 4.7e-15 55.8 0.6 1.6 1 0 0 1 1 1 1 Pregnancy-associated plasma protein-A Reprolysin_5 PF13688.6 EGD93447.1 - 0.00045 20.4 2.4 0.00085 19.5 2.5 1.4 1 1 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_4 PF13583.6 EGD93447.1 - 0.0052 16.4 0.1 0.013 15.1 0.1 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M7 PF02031.16 EGD93447.1 - 0.0082 16.3 0.1 0.022 14.9 0.1 1.7 1 0 0 1 1 1 1 Streptomyces extracellular neutral proteinase (M7) family Reprolysin_3 PF13582.6 EGD93447.1 - 0.0094 16.5 0.5 0.025 15.1 0.5 1.9 1 1 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.6 EGD93447.1 - 0.0095 15.8 0.8 0.014 15.3 0.1 1.7 2 0 0 2 2 2 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M10 PF00413.24 EGD93447.1 - 0.072 12.9 0.0 0.091 12.6 0.0 1.3 1 0 0 1 1 1 0 Matrixin AIM24 PF01987.17 EGD93448.1 - 1.3e-50 172.0 0.2 1.6e-50 171.7 0.2 1.1 1 0 0 1 1 1 1 Mitochondrial biogenesis AIM24 ABC_membrane PF00664.23 EGD93449.1 - 5.2e-41 141.1 13.2 6.6e-41 140.8 13.2 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 EGD93449.1 - 5.6e-34 117.6 0.0 1.1e-33 116.6 0.0 1.5 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 EGD93449.1 - 1.1e-05 25.0 0.0 0.0016 17.9 0.0 2.3 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 EGD93449.1 - 0.00014 22.1 0.0 0.00047 20.4 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EGD93449.1 - 0.00019 21.8 0.0 0.00044 20.7 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA_21 PF13304.6 EGD93449.1 - 0.00073 19.4 0.1 0.011 15.6 0.0 2.3 1 1 1 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system MMR_HSR1 PF01926.23 EGD93449.1 - 0.01 15.9 0.0 0.15 12.1 0.0 2.7 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_29 PF13555.6 EGD93449.1 - 0.015 15.0 0.1 0.039 13.7 0.1 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_15 PF13175.6 EGD93449.1 - 0.018 14.8 0.6 0.034 13.8 0.0 1.7 2 0 0 2 2 2 0 AAA ATPase domain AAA_23 PF13476.6 EGD93449.1 - 0.021 15.3 0.0 0.058 13.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.6 EGD93449.1 - 0.025 14.6 0.1 0.37 10.8 0.0 2.4 2 0 0 2 2 2 0 AAA domain Rad17 PF03215.15 EGD93449.1 - 0.028 14.4 0.0 0.059 13.3 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain RsgA_GTPase PF03193.16 EGD93449.1 - 0.033 14.1 0.0 0.13 12.1 0.0 2.0 2 0 0 2 2 2 0 RsgA GTPase AAA_18 PF13238.6 EGD93449.1 - 0.036 14.6 0.0 0.1 13.1 0.0 1.8 1 0 0 1 1 1 0 AAA domain Rop-like PF05082.13 EGD93449.1 - 0.055 13.3 0.0 0.16 11.8 0.0 1.7 1 0 0 1 1 1 0 Rop-like AAA PF00004.29 EGD93449.1 - 0.059 13.8 0.0 0.45 10.9 0.0 2.2 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.6 EGD93449.1 - 0.06 12.9 0.0 0.15 11.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 EGD93449.1 - 0.062 13.0 0.0 0.12 12.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain ATP-synt_ab PF00006.25 EGD93449.1 - 0.066 12.9 0.0 0.12 12.0 0.0 1.4 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_28 PF13521.6 EGD93449.1 - 0.067 13.4 0.0 0.23 11.7 0.0 1.9 2 0 0 2 2 1 0 AAA domain GPAT_N PF14829.6 EGD93449.1 - 0.067 13.2 0.0 8.3 6.5 0.0 2.5 2 0 0 2 2 2 0 Glycerol-3-phosphate acyltransferase N-terminal G-alpha PF00503.20 EGD93449.1 - 0.069 12.3 0.0 0.13 11.4 0.0 1.5 1 0 0 1 1 1 0 G-protein alpha subunit DUF629 PF04780.12 EGD93449.1 - 0.22 10.0 0.0 0.34 9.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF629) IstB_IS21 PF01695.17 EGD93449.1 - 0.42 10.3 2.4 13 5.5 0.0 3.0 4 0 0 4 4 3 0 IstB-like ATP binding protein DUF2013 PF09431.10 EGD93450.1 - 1.3e-50 171.1 2.7 1.3e-50 171.1 2.7 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF2013) Glyco_hydro_17 PF00332.18 EGD93451.1 - 1.2e-05 25.1 4.0 1.7e-05 24.6 0.4 2.3 1 1 1 2 2 2 1 Glycosyl hydrolases family 17 Aminotran_1_2 PF00155.21 EGD93452.1 - 2e-34 119.3 0.0 2.6e-34 119.0 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 EGD93452.1 - 0.04 12.5 0.0 0.34 9.4 0.0 2.0 2 0 0 2 2 2 0 Cys/Met metabolism PLP-dependent enzyme Zn_clus PF00172.18 EGD93453.1 - 0.0084 16.2 1.0 0.0084 16.2 1.0 2.3 3 0 0 3 3 3 1 Fungal Zn(2)-Cys(6) binuclear cluster domain ATPgrasp_N PF18130.1 EGD93454.1 - 5.8e-17 62.0 0.0 1.8e-16 60.4 0.0 1.9 1 0 0 1 1 1 1 ATP-grasp N-terminal domain ATP-grasp_4 PF13535.6 EGD93454.1 - 1.2e-08 34.7 0.0 5.9e-08 32.5 0.0 2.2 1 1 0 1 1 1 1 ATP-grasp domain Dala_Dala_lig_C PF07478.13 EGD93454.1 - 2.2e-08 33.9 0.0 2.2e-07 30.6 0.0 2.1 2 0 0 2 2 2 1 D-ala D-ala ligase C-terminus ATP-grasp_3 PF02655.14 EGD93454.1 - 0.0015 18.6 0.0 0.039 14.0 0.0 2.3 2 0 0 2 2 2 1 ATP-grasp domain CPSase_L_D2 PF02786.17 EGD93454.1 - 0.01 15.4 0.0 0.034 13.6 0.0 1.8 2 0 0 2 2 2 0 Carbamoyl-phosphate synthase L chain, ATP binding domain AP_endonuc_2 PF01261.24 EGD93454.1 - 0.018 14.5 0.0 0.034 13.6 0.0 1.4 1 0 0 1 1 1 0 Xylose isomerase-like TIM barrel GARS_A PF01071.19 EGD93454.1 - 0.032 14.0 0.0 0.057 13.2 0.0 1.3 1 0 0 1 1 1 0 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain Glucan_synthase PF02364.15 EGD93455.1 - 0 1370.0 0.0 0 1369.5 0.0 1.2 1 0 0 1 1 1 1 1,3-beta-glucan synthase component FKS1_dom1 PF14288.6 EGD93455.1 - 2.2e-43 147.7 0.2 6e-43 146.3 0.2 1.8 1 0 0 1 1 1 1 1,3-beta-glucan synthase subunit FKS1, domain-1 SLX9 PF15341.6 EGD93456.1 - 0.1 13.0 12.2 0.13 12.7 12.2 1.1 1 0 0 1 1 1 0 Ribosome biogenesis protein SLX9 UPF0239 PF06783.11 EGD93456.1 - 5.9 7.1 10.8 0.74 10.0 3.5 2.1 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0239) PGA2 PF07543.12 EGD93456.1 - 9.2 6.2 14.6 12 5.8 14.6 1.1 1 0 0 1 1 1 0 Protein trafficking PGA2 CDC45 PF02724.14 EGD93456.1 - 9.6 4.4 12.9 11 4.2 12.9 1.0 1 0 0 1 1 1 0 CDC45-like protein Glyco_hydro_72 PF03198.14 EGD93457.1 - 2.6e-132 440.9 7.9 3.3e-132 440.5 7.9 1.1 1 0 0 1 1 1 1 Glucanosyltransferase X8 PF07983.13 EGD93457.1 - 2.2e-26 92.3 3.9 6.1e-26 90.9 3.9 1.8 1 0 0 1 1 1 1 X8 domain Cellulase PF00150.18 EGD93457.1 - 0.0025 17.3 1.4 0.7 9.3 0.2 2.2 2 0 0 2 2 2 2 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_2_C PF02836.17 EGD93457.1 - 0.0045 16.1 4.0 0.019 14.1 3.8 2.0 1 1 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Glyco_hydro_114 PF03537.13 EGD93457.1 - 0.072 12.4 1.1 9.2 5.5 0.3 2.2 2 0 0 2 2 2 0 Glycoside-hydrolase family GH114 SprT-like PF10263.9 EGD93458.1 - 3.5e-36 123.5 0.6 6.4e-36 122.6 0.2 1.6 2 0 0 2 2 2 1 SprT-like family Zn_ribbon_SprT PF17283.2 EGD93458.1 - 2.9e-07 30.3 6.2 7.6e-07 28.9 6.2 1.8 1 0 0 1 1 1 1 SprT-like zinc ribbon domain Zn-ribbon_8 PF09723.10 EGD93458.1 - 0.98 9.6 4.7 2.8 8.1 2.3 2.6 2 0 0 2 2 2 0 Zinc ribbon domain Mog1 PF04603.12 EGD93459.1 - 6.1e-31 107.6 0.0 8.7e-31 107.1 0.0 1.2 1 0 0 1 1 1 1 Ran-interacting Mog1 protein DUF2576 PF10845.8 EGD93459.1 - 0.015 14.9 0.0 0.033 13.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2576) NYN PF01936.18 EGD93460.1 - 0.00021 21.8 0.1 0.0028 18.1 0.1 2.3 1 1 0 1 1 1 1 NYN domain HSP9_HSP12 PF04119.12 EGD93461.1 - 2.6e-26 91.8 3.7 2.6e-26 91.8 3.7 1.8 2 0 0 2 2 2 1 Heat shock protein 9/12 Chlorosome_CsmC PF11098.8 EGD93461.1 - 0.019 14.9 0.2 0.024 14.6 0.2 1.1 1 0 0 1 1 1 0 Chlorosome envelope protein C COG6 PF06419.11 EGD93462.1 - 4.2e-207 689.3 0.5 4.8e-207 689.1 0.5 1.0 1 0 0 1 1 1 1 Conserved oligomeric complex COG6 Transcrip_act PF04949.13 EGD93462.1 - 0.0032 17.4 0.3 0.013 15.4 0.3 2.2 1 0 0 1 1 1 1 Transcriptional activator NIF3 PF01784.18 EGD93463.1 - 2.5e-51 174.7 0.0 3.2e-50 171.1 0.0 2.1 1 1 0 1 1 1 1 NIF3 (NGG1p interacting factor 3) DUF5525 PF17663.1 EGD93463.1 - 0.021 13.0 0.1 0.024 12.7 0.1 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5525) BolA PF01722.18 EGD93464.1 - 1.1e-19 70.5 0.0 1.5e-19 70.0 0.0 1.2 1 0 0 1 1 1 1 BolA-like protein Redoxin PF08534.10 EGD93465.1 - 1.2e-30 106.2 0.0 1.4e-30 105.9 0.0 1.0 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 EGD93465.1 - 3.4e-07 30.2 0.0 4.5e-07 29.8 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family HSF_DNA-bind PF00447.17 EGD93466.1 - 2.3e-31 108.3 1.4 7.7e-31 106.6 1.4 2.0 1 0 0 1 1 1 1 HSF-type DNA-binding Response_reg PF00072.24 EGD93466.1 - 3.4e-22 78.7 0.0 7.3e-22 77.7 0.0 1.6 1 0 0 1 1 1 1 Response regulator receiver domain PIP5K PF01504.18 EGD93466.1 - 0.0015 17.8 0.0 0.14 11.3 0.0 2.7 2 2 0 2 2 2 2 Phosphatidylinositol-4-phosphate 5-Kinase COA2 PF17051.5 EGD93467.1 - 0.23 11.5 1.3 12 6.0 0.3 2.5 2 1 1 3 3 3 0 Cytochrome C oxidase assembly factor 2 Antifungal_pept PF11410.8 EGD93468.1 - 0.097 12.6 13.8 0.16 11.9 1.0 3.4 3 1 0 3 3 3 0 Antifungal peptide Tryp_inh PF17983.1 EGD93468.1 - 3.5 7.8 15.1 0.28 11.3 3.6 2.8 2 1 0 2 2 2 0 Trypsin inhibitors 1,2 and 3 W2 PF02020.18 EGD93469.1 - 1.8e-18 66.4 1.9 1.8e-18 66.4 1.9 3.1 3 0 0 3 3 3 1 eIF4-gamma/eIF5/eIF2-epsilon Hexapep PF00132.24 EGD93469.1 - 2.6e-13 49.1 35.6 1.2e-06 28.0 4.4 3.5 1 1 4 5 5 5 5 Bacterial transferase hexapeptide (six repeats) NTP_transferase PF00483.23 EGD93469.1 - 6.3e-05 22.7 0.0 0.00013 21.7 0.0 1.4 1 0 0 1 1 1 1 Nucleotidyl transferase Hexapep_2 PF14602.6 EGD93469.1 - 0.00052 19.7 11.3 0.0023 17.6 2.8 2.9 2 1 0 2 2 2 2 Hexapeptide repeat of succinyl-transferase DUF4954 PF16314.5 EGD93469.1 - 0.02 13.0 2.0 0.035 12.3 2.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4954) Fucokinase PF07959.12 EGD93469.1 - 0.058 12.3 0.3 0.15 10.9 0.3 1.6 1 1 0 1 1 1 0 L-fucokinase IBR PF01485.21 EGD93470.1 - 8.1e-23 80.4 49.0 7.5e-13 48.5 5.7 4.4 3 1 1 4 4 4 3 IBR domain, a half RING-finger domain zf-RING_2 PF13639.6 EGD93470.1 - 0.00089 19.5 8.7 0.00089 19.5 8.7 4.0 3 1 1 4 4 4 2 Ring finger domain UN_NPL4 PF11543.8 EGD93470.1 - 0.0011 19.4 0.0 0.0019 18.6 0.0 1.4 1 0 0 1 1 1 1 Nuclear pore localisation protein NPL4 zf-C3HC4 PF00097.25 EGD93470.1 - 0.0016 18.3 5.4 0.0016 18.3 5.4 4.5 3 1 1 4 4 4 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EGD93470.1 - 0.0063 16.3 5.6 0.0063 16.3 5.6 5.0 3 1 1 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EGD93470.1 - 0.012 15.5 9.6 0.012 15.5 9.6 3.1 3 0 0 3 3 3 0 zinc-RING finger domain Mito_carr PF00153.27 EGD93471.1 - 1.8e-65 216.9 6.3 5.6e-22 77.5 0.1 3.0 2 1 1 3 3 3 3 Mitochondrial carrier protein PBP-Tp47_a PF14889.6 EGD93471.1 - 0.075 12.7 0.0 0.83 9.3 0.0 2.1 2 0 0 2 2 2 0 Penicillin-binding protein Tp47 domain a Serine_protease PF18405.1 EGD93471.1 - 0.18 10.9 3.1 1.3 8.1 0.2 3.1 2 1 1 3 3 3 0 Gammaproteobacterial serine protease tRNA-synt_1 PF00133.22 EGD93472.1 - 1.7e-34 119.0 0.0 1.7e-24 86.1 0.0 3.3 2 1 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 EGD93472.1 - 2.1e-15 56.4 0.0 3.7e-10 39.1 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class I (M) Anticodon_1 PF08264.13 EGD93472.1 - 2e-11 44.1 0.0 5.7e-11 42.6 0.0 1.8 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1e PF01406.19 EGD93472.1 - 4.2e-07 29.6 0.0 8e-07 28.7 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1f PF01921.18 EGD93472.1 - 0.02 13.8 0.0 0.15 10.9 0.0 2.2 2 0 0 2 2 2 0 tRNA synthetases class I (K) L51_S25_CI-B8 PF05047.16 EGD93473.1 - 2.8e-13 49.5 0.0 5e-13 48.7 0.0 1.5 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain LRS4 PF10422.9 EGD93473.1 - 0.25 10.9 3.0 0.35 10.4 3.0 1.2 1 0 0 1 1 1 0 Monopolin complex subunit LRS4 DUF1751 PF08551.10 EGD93474.1 - 4.8e-29 100.9 0.5 1e-28 99.8 0.5 1.6 1 0 0 1 1 1 1 Eukaryotic integral membrane protein (DUF1751) Rhomboid PF01694.22 EGD93474.1 - 0.00012 22.1 10.4 0.00031 20.8 10.4 1.6 1 0 0 1 1 1 1 Rhomboid family ANAPC4_WD40 PF12894.7 EGD93475.1 - 5.7e-07 29.8 0.1 0.0012 19.1 0.0 4.8 3 1 2 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EGD93475.1 - 8.1e-07 29.6 1.6 6.2 7.9 0.0 5.7 7 1 0 7 7 7 2 WD domain, G-beta repeat eIF2A PF08662.11 EGD93475.1 - 0.095 12.6 0.0 0.25 11.2 0.0 1.7 1 0 0 1 1 1 0 Eukaryotic translation initiation factor eIF2A LisH PF08513.11 EGD93475.1 - 0.15 12.1 0.0 0.29 11.2 0.0 1.5 1 0 0 1 1 1 0 LisH PD40 PF07676.12 EGD93475.1 - 4.1 7.5 7.5 57 3.8 0.1 4.2 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat AATF-Che1 PF13339.6 EGD93476.1 - 0.2 12.3 1.7 1.1 9.9 1.7 2.2 1 1 0 1 1 1 0 Apoptosis antagonizing transcription factor Chorismate_bind PF00425.18 EGD93477.1 - 1.9e-72 243.9 0.0 2.8e-72 243.4 0.0 1.2 1 0 0 1 1 1 1 chorismate binding enzyme Anth_synt_I_N PF04715.13 EGD93477.1 - 3.5e-22 79.1 0.0 1.2e-18 67.6 0.0 3.3 2 1 1 3 3 3 2 Anthranilate synthase component I, N terminal region DUF1720 PF08226.11 EGD93478.1 - 4.8e-09 36.5 40.3 4.8e-09 36.5 40.3 5.5 1 1 2 3 3 3 1 Domain of unknown function (DUF1720) Pkinase PF00069.25 EGD93479.1 - 5.2e-12 45.7 0.0 7.2e-08 32.1 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EGD93479.1 - 1.5e-06 27.7 0.0 6.2e-06 25.7 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase APH PF01636.23 EGD93479.1 - 0.024 14.5 0.1 0.042 13.7 0.1 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.14 EGD93479.1 - 0.056 12.8 0.0 0.097 12.0 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 EGD93479.1 - 0.17 11.4 0.0 0.3 10.7 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase CLASP_N PF12348.8 EGD93480.1 - 2.2e-06 27.4 0.0 0.0046 16.6 0.0 2.5 3 0 0 3 3 2 2 CLASP N terminal TAN PF11640.8 EGD93480.1 - 2.7e-05 24.3 0.9 0.00011 22.3 0.0 2.3 2 0 0 2 2 2 1 Telomere-length maintenance and DNA damage repair Adaptin_N PF01602.20 EGD93480.1 - 6.1e-05 21.8 0.2 0.00046 18.9 0.2 2.5 1 1 0 1 1 1 1 Adaptin N terminal region HEAT_2 PF13646.6 EGD93480.1 - 9.9e-05 22.7 0.2 0.018 15.4 0.1 3.3 3 1 1 4 4 3 1 HEAT repeats Cnd1 PF12717.7 EGD93480.1 - 0.0009 19.3 0.0 0.46 10.5 0.0 2.7 3 0 0 3 3 2 1 non-SMC mitotic condensation complex subunit 1 Macoilin PF09726.9 EGD93480.1 - 0.0016 17.1 0.6 0.0022 16.7 0.0 1.5 2 0 0 2 2 2 1 Macoilin family HEAT PF02985.22 EGD93480.1 - 0.0035 17.5 0.0 0.98 9.9 0.0 3.6 3 0 0 3 3 3 1 HEAT repeat DCB PF16213.5 EGD93480.1 - 0.05 13.3 0.1 0.32 10.7 0.0 2.3 2 0 0 2 2 2 0 Dimerisation and cyclophilin-binding domain of Mon2 Exonuc_VII_L PF02601.15 EGD93480.1 - 0.081 12.5 8.0 0.49 9.9 3.2 2.5 2 0 0 2 2 2 0 Exonuclease VII, large subunit HEAT_EZ PF13513.6 EGD93480.1 - 0.11 13.1 0.4 1.4 9.5 0.2 2.9 3 0 0 3 3 2 0 HEAT-like repeat G-gamma PF00631.22 EGD93480.1 - 0.18 11.8 0.9 0.76 9.8 0.9 2.1 1 0 0 1 1 1 0 GGL domain Latarcin PF10279.9 EGD93480.1 - 0.24 11.9 3.1 6.5 7.2 4.5 2.6 3 1 0 3 3 3 0 Latarcin precursor HsbA PF12296.8 EGD93480.1 - 0.42 11.1 2.4 17 5.9 0.0 3.3 3 1 0 3 3 3 0 Hydrophobic surface binding protein A Proteasom_PSMB PF10508.9 EGD93480.1 - 0.75 8.2 3.5 9.1 4.6 0.0 2.4 3 0 0 3 3 3 0 Proteasome non-ATPase 26S subunit Spc7 PF08317.11 EGD93480.1 - 0.77 8.6 14.7 0.19 10.5 11.4 1.7 2 0 0 2 2 2 0 Spc7 kinetochore protein Atg14 PF10186.9 EGD93480.1 - 1.1 8.2 6.0 2.1 7.3 6.0 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 JIP_LZII PF16471.5 EGD93480.1 - 1.9 8.7 7.4 2.4 8.4 5.6 2.1 1 1 0 1 1 1 0 JNK-interacting protein leucine zipper II Fez1 PF06818.15 EGD93480.1 - 2.7 8.4 16.0 0.4 11.1 10.2 2.1 2 0 0 2 2 2 0 Fez1 MCC-bdg_PDZ PF10506.9 EGD93480.1 - 2.8 8.0 6.6 3.8 7.6 2.7 2.8 2 0 0 2 2 2 0 PDZ domain of MCC-2 bdg protein for Usher syndrome ERM PF00769.19 EGD93480.1 - 4 7.2 22.6 2.5 7.8 16.0 2.5 2 0 0 2 2 2 0 Ezrin/radixin/moesin family Ribosomal_L7Ae PF01248.26 EGD93481.1 - 7.8e-21 73.6 0.3 1.3e-20 72.9 0.3 1.4 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family RRP36 PF06102.12 EGD93481.1 - 0.01 15.8 0.5 0.01 15.8 0.5 2.1 2 0 0 2 2 2 0 rRNA biogenesis protein RRP36 DUF1048 PF06304.11 EGD93481.1 - 0.042 14.3 0.0 0.13 12.7 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1048) Clat_adaptor_s PF01217.20 EGD93483.1 - 2.2e-42 144.4 0.0 3.5e-42 143.7 0.0 1.3 1 1 0 1 1 1 1 Clathrin adaptor complex small chain MMR_HSR1 PF01926.23 EGD93484.1 - 1.5e-17 63.7 0.0 2.5e-17 63.0 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase AIG1 PF04548.16 EGD93484.1 - 7.5e-07 28.7 0.0 9.6e-07 28.3 0.0 1.2 1 0 0 1 1 1 1 AIG1 family Dynamin_N PF00350.23 EGD93484.1 - 3.1e-06 27.3 0.0 0.00028 21.0 0.0 2.3 2 0 0 2 2 2 1 Dynamin family GTP_EFTU PF00009.27 EGD93484.1 - 6.9e-06 25.7 0.0 3.5e-05 23.4 0.0 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EGD93484.1 - 0.00013 21.9 0.6 0.001 19.0 0.2 2.2 2 1 0 2 2 2 1 RsgA GTPase FeoB_N PF02421.18 EGD93484.1 - 0.001 18.6 0.0 0.0014 18.2 0.0 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B SRPRB PF09439.10 EGD93484.1 - 0.0027 17.2 0.0 0.0037 16.7 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Septin PF00735.18 EGD93484.1 - 0.0092 15.3 0.0 0.017 14.4 0.0 1.4 1 0 0 1 1 1 1 Septin PduV-EutP PF10662.9 EGD93484.1 - 0.13 12.0 0.0 0.28 10.9 0.0 1.6 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation TniB PF05621.11 EGD93484.1 - 0.14 11.5 0.0 0.36 10.2 0.0 1.7 1 0 0 1 1 1 0 Bacterial TniB protein CLP1_P PF16575.5 EGD93484.1 - 0.17 11.7 0.1 6 6.6 0.0 2.2 2 0 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop WD40 PF00400.32 EGD93485.1 - 1.2e-40 136.7 16.7 3.4e-06 27.7 0.2 7.7 7 0 0 7 7 7 7 WD domain, G-beta repeat F-box-like PF12937.7 EGD93485.1 - 2.3e-10 40.2 0.1 5.2e-10 39.1 0.1 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EGD93485.1 - 3e-10 39.7 0.2 6e-10 38.7 0.2 1.5 1 0 0 1 1 1 1 F-box domain ANAPC4_WD40 PF12894.7 EGD93485.1 - 3.7e-05 23.9 1.2 8.3 6.8 0.0 4.6 3 2 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EGD93485.1 - 8.2e-05 21.4 3.3 4.9 5.7 0.2 5.2 4 2 1 6 6 6 3 Nucleoporin Nup120/160 F-box_4 PF15966.5 EGD93485.1 - 0.0026 17.6 0.0 0.0077 16.1 0.0 1.8 1 0 0 1 1 1 1 F-box Vert_IL3-reg_TF PF06529.11 EGD93485.1 - 0.032 13.4 0.1 0.057 12.5 0.1 1.3 1 0 0 1 1 1 0 Vertebrate interleukin-3 regulated transcription factor FliG_C PF01706.16 EGD93485.1 - 0.096 12.9 0.0 0.2 11.8 0.0 1.4 1 0 0 1 1 1 0 FliG C-terminal domain AcylCoA_DH_N PF12418.8 EGD93485.1 - 0.16 12.0 0.2 0.49 10.5 0.2 1.9 1 0 0 1 1 1 0 Acyl-CoA dehydrogenase N terminal HORMA PF02301.18 EGD93486.1 - 7.4e-71 238.1 0.4 1.5e-70 237.1 0.0 1.7 2 0 0 2 2 2 1 HORMA domain DUF4407 PF14362.6 EGD93487.1 - 8.7 5.6 14.4 1.3 8.3 6.9 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Nuc_sug_transp PF04142.15 EGD93488.1 - 3.6e-83 279.3 6.6 4.8e-83 278.9 6.6 1.1 1 0 0 1 1 1 1 Nucleotide-sugar transporter EamA PF00892.20 EGD93488.1 - 0.0068 16.6 9.9 0.0068 16.6 9.9 2.9 2 2 0 2 2 2 1 EamA-like transporter family Sec63 PF02889.16 EGD93489.1 - 1.7e-33 115.9 0.0 2.5e-33 115.3 0.0 1.3 1 0 0 1 1 1 1 Sec63 Brl domain DEAD PF00270.29 EGD93489.1 - 2e-27 96.1 0.1 5e-27 94.8 0.1 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 EGD93489.1 - 1.5e-14 54.3 0.0 3.2e-14 53.3 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EGD93489.1 - 2.9e-08 34.0 0.0 1.3e-07 32.0 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain AAA_19 PF13245.6 EGD93489.1 - 0.0003 21.2 0.0 0.0016 18.8 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 EGD93489.1 - 0.0013 19.0 0.0 0.004 17.4 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EGD93489.1 - 0.0032 17.2 0.0 0.0067 16.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 EGD93489.1 - 0.035 14.5 0.0 0.095 13.1 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Helicase_RecD PF05127.14 EGD93489.1 - 0.08 12.8 0.1 0.81 9.5 0.0 2.3 2 0 0 2 2 2 0 Helicase LRR_4 PF12799.7 EGD93490.1 - 0.0002 21.7 2.3 0.00095 19.5 1.2 2.6 2 0 0 2 2 2 1 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EGD93490.1 - 0.039 14.0 5.4 31 5.0 0.1 4.5 4 0 0 4 4 4 0 Leucine Rich repeat LRR_8 PF13855.6 EGD93490.1 - 0.041 13.7 1.0 0.57 10.0 0.8 2.6 2 1 0 2 2 2 0 Leucine rich repeat LRR_1 PF00560.33 EGD93490.1 - 0.17 12.5 0.4 1.1e+02 4.0 0.1 3.6 3 0 0 3 3 3 0 Leucine Rich Repeat Acid_PPase PF12689.7 EGD93491.1 - 4.7e-69 231.6 0.0 5.5e-69 231.3 0.0 1.0 1 0 0 1 1 1 1 Acid Phosphatase HAD PF12710.7 EGD93491.1 - 0.2 12.1 0.7 6.2 7.2 0.0 2.2 1 1 1 2 2 2 0 haloacid dehalogenase-like hydrolase Hexapep PF00132.24 EGD93492.1 - 1.9e-08 33.7 8.1 0.0013 18.3 3.3 4.2 2 2 1 3 3 3 3 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 EGD93492.1 - 5.7e-05 22.8 4.2 0.0099 15.6 1.9 3.4 3 0 0 3 3 3 2 Hexapeptide repeat of succinyl-transferase TPR_MLP1_2 PF07926.12 EGD93493.1 - 2.4e-37 127.9 30.5 2.4e-37 127.9 30.5 17.5 6 6 11 18 18 18 9 TPR/MLP1/MLP2-like protein Baculo_PEP_C PF04513.12 EGD93493.1 - 0.0011 19.0 4.4 0.0011 19.0 4.4 13.1 9 5 6 16 16 16 4 Baculovirus polyhedron envelope protein, PEP, C terminus Cbl_N PF02262.16 EGD93493.1 - 0.56 10.2 7.6 0.94 9.5 0.2 4.7 3 0 0 3 3 3 0 CBL proto-oncogene N-terminal domain 1 Fez1 PF06818.15 EGD93493.1 - 3.6 8.0 245.7 0.013 15.9 18.4 12.5 2 2 10 12 12 12 0 Fez1 TFIIE_beta PF02186.15 EGD93494.1 - 1e-22 80.1 0.1 1.2e-21 76.8 0.0 2.5 2 1 0 2 2 2 1 TFIIE beta subunit core domain TFA2_Winged_2 PF18121.1 EGD93494.1 - 4.4e-22 77.5 1.5 6.9e-22 76.9 0.3 2.0 3 0 0 3 3 3 1 TFA2 Winged helix domain 2 DHBP_synthase PF00926.19 EGD93495.1 - 2.2e-72 242.6 0.0 2.6e-72 242.4 0.0 1.0 1 0 0 1 1 1 1 3,4-dihydroxy-2-butanone 4-phosphate synthase F-box PF00646.33 EGD93496.1 - 1.4e-08 34.4 1.1 2.6e-08 33.6 1.1 1.5 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EGD93496.1 - 2.2e-06 27.4 2.5 4.1e-06 26.6 2.5 1.5 1 0 0 1 1 1 1 F-box-like Pkinase PF00069.25 EGD93497.1 - 5.1e-61 206.3 0.0 1.7e-60 204.7 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD93497.1 - 2.6e-26 92.5 0.0 3.7e-26 92.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EGD93497.1 - 6.7e-10 38.7 0.0 9e-10 38.3 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 EGD93497.1 - 0.0033 16.8 0.0 0.032 13.6 0.0 2.1 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family UQ_con PF00179.26 EGD93498.1 - 7.1e-49 165.1 0.0 8.5e-49 164.8 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 EGD93498.1 - 0.0001 22.5 0.0 0.00017 21.9 0.0 1.4 1 1 0 1 1 1 1 RWD domain Prok-E2_B PF14461.6 EGD93498.1 - 0.0043 16.8 0.0 0.0064 16.2 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.13 EGD93498.1 - 0.0059 16.5 0.0 0.0084 16.0 0.0 1.4 1 0 0 1 1 1 1 UEV domain UFC1 PF08694.11 EGD93498.1 - 0.11 12.1 0.0 0.66 9.6 0.0 1.9 2 0 0 2 2 2 0 Ubiquitin-fold modifier-conjugating enzyme 1 Nucleos_tra2_C PF07662.13 EGD93499.1 - 7.5e-73 244.8 1.0 7.5e-73 244.8 1.0 3.6 4 0 0 4 4 4 1 Na+ dependent nucleoside transporter C-terminus Nucleos_tra2_N PF01773.20 EGD93499.1 - 1.5e-22 79.9 4.4 1.5e-22 79.9 4.4 3.0 3 0 0 3 3 3 1 Na+ dependent nucleoside transporter N-terminus FA_desaturase PF00487.24 EGD93499.1 - 0.041 13.7 0.0 0.041 13.7 0.0 3.1 3 1 0 3 3 3 0 Fatty acid desaturase Prenyltransf PF01255.19 EGD93501.1 - 1.3e-67 227.7 0.0 1.6e-67 227.3 0.0 1.1 1 0 0 1 1 1 1 Putative undecaprenyl diphosphate synthase DUF2600 PF10776.9 EGD93501.1 - 0.11 11.3 0.0 0.19 10.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2600) PnpCD_PnpD_N PF18191.1 EGD93501.1 - 0.14 11.8 0.0 0.3 10.7 0.0 1.5 1 0 0 1 1 1 0 Hydroquinone 1,2-dioxygenase large subunit N-terminal Porin_10 PF14121.6 EGD93501.1 - 0.25 9.9 0.5 0.37 9.3 0.1 1.3 1 1 0 1 1 1 0 Putative porin UbiA PF01040.18 EGD93502.1 - 7e-15 55.0 0.1 8.6e-15 54.7 0.1 1.0 1 0 0 1 1 1 1 UbiA prenyltransferase family Glyco_transf_20 PF00982.21 EGD93503.1 - 2.5e-200 666.2 0.0 2.9e-200 666.0 0.0 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 20 Glyco_transf_5 PF08323.11 EGD93503.1 - 0.015 15.0 0.2 0.039 13.6 0.0 1.9 2 0 0 2 2 2 0 Starch synthase catalytic domain Lactamase_B PF00753.27 EGD93504.1 - 5.6e-17 62.4 2.4 6.5e-16 58.9 2.4 2.1 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily BLACT_WH PF17778.1 EGD93504.1 - 2.7e-16 59.3 0.1 5.1e-16 58.4 0.1 1.5 1 0 0 1 1 1 1 Beta-lactamase associated winged helix domain Lactamase_B_2 PF12706.7 EGD93504.1 - 1.8e-06 27.6 0.7 3.3e-06 26.7 0.6 1.4 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 EGD93504.1 - 0.0035 17.2 0.0 0.0051 16.7 0.0 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain YmzC PF14157.6 EGD93504.1 - 0.14 12.3 0.0 0.31 11.2 0.0 1.5 1 0 0 1 1 1 0 YmzC-like protein DUF1450 PF07293.11 EGD93504.1 - 0.17 11.7 0.0 5.4 6.9 0.0 3.0 4 0 0 4 4 4 0 Protein of unknown function (DUF1450) Aconitase PF00330.20 EGD93505.1 - 5.5e-149 497.1 0.0 6.9e-149 496.8 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 EGD93505.1 - 2.6e-43 147.5 0.0 4.5e-43 146.7 0.0 1.4 1 0 0 1 1 1 1 Aconitase C-terminal domain zf-C2H2_jaz PF12171.8 EGD93506.1 - 6.7e-09 35.8 3.0 6.7e-09 35.8 3.0 1.9 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-U1 PF06220.12 EGD93506.1 - 0.0067 16.2 0.8 0.01 15.6 0.2 1.7 2 0 0 2 2 2 1 U1 zinc finger zf-C2H2_2 PF12756.7 EGD93506.1 - 0.065 13.6 0.7 0.093 13.1 0.7 1.3 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) Mito_carr PF00153.27 EGD93507.1 - 2e-49 165.4 3.9 1.5e-19 69.7 0.1 3.7 3 1 0 3 3 3 3 Mitochondrial carrier protein SNF2_N PF00176.23 EGD93508.1 - 1.7e-57 194.8 0.0 2.6e-57 194.1 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Rad54_N PF08658.10 EGD93508.1 - 1.8e-57 194.4 0.3 3.1e-57 193.7 0.3 1.4 1 0 0 1 1 1 1 Rad54 N terminal ResIII PF04851.15 EGD93508.1 - 3.5e-09 36.9 0.0 6.4e-09 36.0 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Vac14_Fig4_bd PF11916.8 EGD93509.1 - 6.9e-62 208.3 7.3 7.7e-62 208.1 4.8 2.1 2 0 0 2 2 2 1 Vacuolar protein 14 C-terminal Fig4p binding Vac14_Fab1_bd PF12755.7 EGD93509.1 - 8.9e-44 148.0 0.1 3.1e-40 136.7 0.0 4.1 4 0 0 4 4 4 1 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.6 EGD93509.1 - 6.4e-08 32.9 3.4 0.2 12.2 0.1 5.8 5 1 1 6 6 6 2 HEAT-like repeat HEAT PF02985.22 EGD93509.1 - 6.1e-06 26.0 0.3 0.44 10.9 0.0 6.1 6 0 0 6 6 6 1 HEAT repeat Cnd1 PF12717.7 EGD93509.1 - 0.00075 19.6 2.2 0.055 13.5 0.2 3.8 4 0 0 4 4 4 1 non-SMC mitotic condensation complex subunit 1 Arm PF00514.23 EGD93509.1 - 0.055 13.5 0.0 49 4.2 0.0 4.6 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat APH PF01636.23 EGD93510.1 - 3.2e-12 46.9 0.0 6.1e-11 42.7 0.0 2.2 1 1 0 1 1 1 1 Phosphotransferase enzyme family DUF1679 PF07914.11 EGD93510.1 - 6.5e-06 25.3 0.1 0.0095 14.8 0.1 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF1679) EcKinase PF02958.20 EGD93510.1 - 0.00085 18.7 0.0 0.0022 17.3 0.0 1.6 1 0 0 1 1 1 1 Ecdysteroid kinase Glyco_hydro_47 PF01532.20 EGD93512.1 - 3.6e-183 609.6 0.0 4.3e-183 609.4 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 APG9 PF04109.16 EGD93513.1 - 9.4e-163 542.6 12.6 2.4e-112 376.4 4.1 2.1 2 0 0 2 2 2 2 Autophagy protein Apg9 AMP-binding PF00501.28 EGD93514.1 - 1.2e-147 491.9 0.0 2.1e-73 247.4 0.2 2.5 2 0 0 2 2 2 2 AMP-binding enzyme Condensation PF00668.20 EGD93514.1 - 1.1e-67 228.7 0.0 6.8e-41 140.4 0.0 3.0 3 0 0 3 3 3 2 Condensation domain PP-binding PF00550.25 EGD93514.1 - 4.5e-12 46.1 0.2 1.3e-07 31.8 0.0 2.9 2 0 0 2 2 2 2 Phosphopantetheine attachment site AMP-binding_C PF13193.6 EGD93514.1 - 0.008 17.1 0.0 0.82 10.7 0.0 3.0 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain DUF5126 PF17166.4 EGD93514.1 - 0.049 13.5 0.0 0.17 11.8 0.0 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF5126) SnoaL_2 PF12680.7 EGD93515.1 - 6.4e-05 23.5 0.0 0.00019 22.0 0.0 1.7 1 1 0 1 1 1 1 SnoaL-like domain Methyltransf_11 PF08241.12 EGD93516.1 - 5.1e-16 59.1 0.0 9.5e-16 58.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EGD93516.1 - 5e-15 56.0 0.0 8.7e-15 55.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EGD93516.1 - 7e-11 41.9 0.0 1.2e-10 41.1 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 EGD93516.1 - 2.5e-10 40.9 0.0 3.8e-10 40.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EGD93516.1 - 5.7e-10 39.2 0.0 7.4e-10 38.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EGD93516.1 - 6.6e-08 32.6 0.0 8.9e-08 32.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EGD93516.1 - 0.0032 17.0 0.0 0.014 14.9 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_32 PF13679.6 EGD93516.1 - 0.22 11.5 0.0 0.3 11.1 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Abhydrolase_1 PF00561.20 EGD93517.1 - 1.2e-13 51.4 0.0 1.9e-13 50.7 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EGD93517.1 - 5.5e-08 32.4 0.0 1.2e-07 31.2 0.0 1.5 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EGD93517.1 - 0.0026 18.4 0.0 0.0055 17.3 0.0 1.6 1 0 0 1 1 1 1 Alpha/beta hydrolase family Esterase PF00756.20 EGD93517.1 - 0.0069 16.1 0.0 0.027 14.1 0.0 1.8 2 0 0 2 2 2 1 Putative esterase CENP-K PF11802.8 EGD93518.1 - 0.0032 17.1 5.5 2.6 7.6 5.0 2.7 2 1 0 2 2 2 2 Centromere-associated protein K Sec34 PF04136.15 EGD93518.1 - 0.065 13.1 0.4 9.4 6.1 0.0 3.2 3 0 0 3 3 3 0 Sec34-like family Fib_alpha PF08702.10 EGD93518.1 - 0.065 13.4 6.2 0.57 10.4 0.3 2.6 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family Sec20 PF03908.13 EGD93518.1 - 0.14 12.1 1.3 1.3 9.0 0.0 2.7 3 0 0 3 3 3 0 Sec20 Syntaxin-6_N PF09177.11 EGD93518.1 - 0.38 11.3 14.4 4 8.1 1.7 3.8 3 1 1 4 4 4 0 Syntaxin 6, N-terminal Spc7 PF08317.11 EGD93518.1 - 0.6 8.9 14.6 0.2 10.5 6.2 2.2 2 0 0 2 2 2 0 Spc7 kinetochore protein Syntaxin_2 PF14523.6 EGD93518.1 - 3.5 8.1 10.1 4.4 7.7 0.1 3.2 3 1 0 3 3 3 0 Syntaxin-like protein ISG65-75 PF11727.8 EGD93518.1 - 6.8 5.8 12.0 0.81 8.9 1.4 2.3 2 0 0 2 2 2 0 Invariant surface glycoprotein Exonuc_VII_L PF02601.15 EGD93518.1 - 8.2 5.9 14.0 2.8e+02 0.8 13.7 2.3 1 1 0 1 1 1 0 Exonuclease VII, large subunit KH_1 PF00013.29 EGD93519.1 - 1.8e-43 146.2 4.0 1e-17 63.7 0.2 3.2 3 0 0 3 3 3 3 KH domain KH_2 PF07650.17 EGD93519.1 - 1.8e-11 43.7 2.0 0.011 15.5 0.1 3.3 3 0 0 3 3 3 3 KH domain KH_4 PF13083.6 EGD93519.1 - 1.2e-05 25.1 0.3 0.78 9.7 0.1 3.3 3 0 0 3 3 3 2 KH domain MOEP19 PF16005.5 EGD93519.1 - 0.00012 22.0 0.0 0.019 15.0 0.0 2.4 2 0 0 2 2 2 1 KH-like RNA-binding domain KH_5 PF13184.6 EGD93519.1 - 0.00039 20.5 7.9 0.21 11.7 0.2 3.4 3 0 0 3 3 3 2 NusA-like KH domain Pol_alpha_B_N PF08418.10 EGD93519.1 - 0.018 15.0 0.6 0.029 14.3 0.6 1.3 1 0 0 1 1 1 0 DNA polymerase alpha subunit B N-terminal AA_permease_2 PF13520.6 EGD93520.1 - 1.6e-53 182.1 41.2 1.9e-53 181.8 41.2 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EGD93520.1 - 3.5e-26 91.9 32.6 4.7e-26 91.4 32.6 1.1 1 0 0 1 1 1 1 Amino acid permease Spec3 PF15795.5 EGD93521.1 - 3.2 8.3 8.1 1.5 9.4 4.7 2.2 2 0 0 2 2 2 0 Ectodermal ciliogenesis protein Raptor_N PF14538.6 EGD93522.1 - 0.007 16.3 0.1 0.028 14.4 0.0 2.0 2 1 1 3 3 3 1 Raptor N-terminal CASPase like domain Acetyltransf_7 PF13508.7 EGD93523.1 - 8.3e-08 32.5 0.0 1.3e-07 31.9 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EGD93523.1 - 9.1e-08 32.4 0.0 1.9e-07 31.3 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EGD93523.1 - 7.9e-06 25.8 0.0 1.3e-05 25.1 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EGD93523.1 - 0.00015 21.9 0.0 0.0018 18.4 0.0 2.2 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EGD93523.1 - 0.022 14.7 0.0 0.042 13.8 0.0 1.5 1 0 0 1 1 1 0 FR47-like protein GAD-like PF08887.11 EGD93523.1 - 0.053 13.3 0.1 0.094 12.5 0.1 1.4 1 0 0 1 1 1 0 GAD-like domain MOZ_SAS PF01853.18 EGD93523.1 - 0.14 11.8 0.0 0.81 9.3 0.0 1.9 2 0 0 2 2 2 0 MOZ/SAS family PI-PLC-Y PF00387.19 EGD93524.1 - 0.091 13.1 0.1 0.23 11.8 0.1 1.6 1 0 0 1 1 1 0 Phosphatidylinositol-specific phospholipase C, Y domain Fungal_trans PF04082.18 EGD93525.1 - 2.8e-13 49.5 0.2 4.6e-13 48.8 0.2 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain NUP214 PF16755.5 EGD93526.1 - 4e-11 42.8 0.0 6.2e-11 42.1 0.0 1.2 1 0 0 1 1 1 1 Nucleoporin or Nuclear pore complex subunit NUP214=Nup159 ANAPC4_WD40 PF12894.7 EGD93526.1 - 2.1e-06 27.9 0.0 0.00097 19.4 0.0 2.4 2 0 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Syntaxin-6_N PF09177.11 EGD93526.1 - 0.018 15.5 0.1 0.046 14.3 0.1 1.7 1 0 0 1 1 1 0 Syntaxin 6, N-terminal Proteasome PF00227.26 EGD93527.1 - 1.2e-47 161.9 0.1 1.4e-47 161.6 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Pr_beta_C PF12465.8 EGD93527.1 - 7.4e-15 54.1 0.1 7.4e-15 54.1 0.1 1.7 2 0 0 2 2 2 1 Proteasome beta subunits C terminal Methyltransf_23 PF13489.6 EGD93529.1 - 4.5e-27 94.9 0.0 6.2e-27 94.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EGD93529.1 - 4.1e-10 40.2 0.0 9.6e-10 39.1 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EGD93529.1 - 2.1e-09 37.4 0.0 3.4e-08 33.4 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EGD93529.1 - 6e-07 30.1 0.0 1.9e-06 28.5 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EGD93529.1 - 1.2e-06 29.0 0.0 2.2e-06 28.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 EGD93529.1 - 0.00067 19.2 0.8 0.002 17.6 0.0 2.1 2 0 0 2 2 2 1 Putative methyltransferase CMAS PF02353.20 EGD93529.1 - 0.02 14.2 0.0 0.034 13.4 0.0 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Ubie_methyltran PF01209.18 EGD93529.1 - 0.031 13.6 0.0 0.22 10.8 0.0 2.2 2 1 0 2 2 2 0 ubiE/COQ5 methyltransferase family PrmA PF06325.13 EGD93529.1 - 0.039 13.3 0.0 0.058 12.8 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 EGD93529.1 - 0.11 12.0 0.0 1.7 8.2 0.0 2.1 2 0 0 2 2 2 0 Methyltransferase small domain Methyltransf_16 PF10294.9 EGD93529.1 - 0.18 11.5 0.0 0.28 10.9 0.0 1.2 1 0 0 1 1 1 0 Lysine methyltransferase Peptidase_M3 PF01432.20 EGD93531.1 - 7.5e-121 404.6 0.0 1e-120 404.1 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M3 Peptidase_M91 PF14891.6 EGD93531.1 - 0.18 12.1 0.0 0.33 11.3 0.0 1.3 1 0 0 1 1 1 0 Effector protein ApoO PF09769.9 EGD93532.1 - 1e-41 142.0 0.1 2.7e-41 140.6 0.1 1.7 2 0 0 2 2 2 1 Apolipoprotein O GRASP55_65 PF04495.14 EGD93533.1 - 5.2e-42 143.4 0.0 5.4e-40 136.9 0.0 2.1 1 1 1 2 2 2 2 GRASP55/65 PDZ-like domain Methyltransf_15 PF09445.10 EGD93534.1 - 1.2e-50 171.3 0.0 1.6e-50 170.9 0.0 1.1 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Met_10 PF02475.16 EGD93534.1 - 9.6e-09 35.3 0.0 1.2e-08 34.9 0.0 1.2 1 0 0 1 1 1 1 Met-10+ like-protein Cons_hypoth95 PF03602.15 EGD93534.1 - 1.9e-08 34.2 0.0 2.7e-08 33.7 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical protein 95 UPF0020 PF01170.18 EGD93534.1 - 2.1e-07 30.8 0.0 3.2e-07 30.2 0.0 1.3 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_18 PF12847.7 EGD93534.1 - 0.00045 20.2 0.0 0.00065 19.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_5 PF01795.19 EGD93534.1 - 0.0006 19.4 0.0 0.0009 18.8 0.0 1.2 1 0 0 1 1 1 1 MraW methylase family Methyltransf_25 PF13649.6 EGD93534.1 - 0.0017 19.0 0.0 0.0035 18.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain N6_Mtase PF02384.16 EGD93534.1 - 0.0033 16.7 0.0 0.0046 16.3 0.0 1.2 1 0 0 1 1 1 1 N-6 DNA Methylase Methyltransf_3 PF01596.17 EGD93534.1 - 0.011 14.9 0.0 0.016 14.4 0.0 1.3 1 0 0 1 1 1 0 O-methyltransferase MTS PF05175.14 EGD93534.1 - 0.017 14.7 0.0 0.025 14.1 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_11 PF08241.12 EGD93534.1 - 0.049 14.3 0.0 0.086 13.5 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain PrmA PF06325.13 EGD93534.1 - 0.055 12.9 0.0 0.075 12.4 0.0 1.1 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) DNA_methylase PF00145.17 EGD93534.1 - 0.071 12.4 0.0 0.09 12.1 0.0 1.1 1 0 0 1 1 1 0 C-5 cytosine-specific DNA methylase DUF3591 PF12157.8 EGD93535.1 - 4.9e-186 618.7 0.5 6.8e-186 618.2 0.5 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3591) zf-CCHC PF00098.23 EGD93535.1 - 0.0049 16.9 0.7 0.0087 16.1 0.7 1.4 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_6 PF15288.6 EGD93535.1 - 0.017 15.0 3.4 0.039 13.8 3.4 1.6 1 0 0 1 1 1 0 Zinc knuckle Pkinase PF00069.25 EGD93536.1 - 1.6e-48 165.3 0.7 2.4e-25 89.4 0.0 3.4 3 0 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.17 EGD93536.1 - 6.9e-20 71.4 0.0 2.2e-12 46.8 0.0 2.4 2 0 0 2 2 2 2 Protein tyrosine kinase APH PF01636.23 EGD93536.1 - 0.019 14.9 0.1 0.058 13.3 0.1 1.8 1 0 0 1 1 1 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EGD93536.1 - 0.028 13.4 0.3 0.052 12.5 0.3 1.4 1 0 0 1 1 1 0 Haspin like kinase domain FKBP_C PF00254.28 EGD93537.1 - 1.3e-30 105.5 0.1 5.7e-30 103.5 0.0 2.1 2 0 0 2 2 2 1 FKBP-type peptidyl-prolyl cis-trans isomerase NPL PF17800.1 EGD93537.1 - 5.3e-30 104.1 2.0 5.3e-30 104.1 2.0 2.8 2 2 0 2 2 2 1 Nucleoplasmin-like domain IMS PF00817.20 EGD93538.1 - 5.5e-40 136.8 0.0 1.4e-39 135.5 0.0 1.8 1 0 0 1 1 1 1 impB/mucB/samB family REV1_C PF16727.5 EGD93538.1 - 1.9e-23 82.7 0.0 4.6e-23 81.4 0.0 1.7 2 0 0 2 2 2 1 DNA repair protein REV1 C-terminal domain IMS_C PF11799.8 EGD93538.1 - 4.1e-14 53.3 0.0 9.2e-14 52.2 0.0 1.6 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain UBM PF14377.6 EGD93538.1 - 1.9e-13 49.3 12.9 1.3e-09 37.2 2.8 4.0 3 0 0 3 3 3 2 Ubiquitin binding region BRCT_2 PF16589.5 EGD93538.1 - 5.1e-10 39.6 0.0 2e-09 37.7 0.0 2.1 2 0 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 EGD93538.1 - 2.4e-06 27.8 0.0 7.8e-06 26.2 0.0 2.0 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain LIG3_BRCT PF16759.5 EGD93538.1 - 3e-06 27.4 0.0 7.2e-06 26.2 0.0 1.6 1 0 0 1 1 1 1 DNA ligase 3 BRCT domain mCpol PF18182.1 EGD93538.1 - 0.00043 20.6 0.0 0.0012 19.2 0.0 1.8 1 0 0 1 1 1 1 minimal CRISPR polymerase domain IMS_HHH PF11798.8 EGD93538.1 - 0.0066 16.7 0.1 0.038 14.3 0.0 2.4 2 0 0 2 2 2 1 IMS family HHH motif PTCB-BRCT PF12738.7 EGD93538.1 - 0.034 14.1 0.0 0.07 13.1 0.0 1.6 1 0 0 1 1 1 0 twin BRCT domain DUF1805 PF08827.11 EGD93538.1 - 0.071 13.4 0.0 0.29 11.5 0.0 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1805) DJ-1_PfpI PF01965.24 EGD93539.1 - 4.8e-21 75.3 0.0 6.3e-21 74.9 0.0 1.2 1 0 0 1 1 1 1 DJ-1/PfpI family GATase PF00117.28 EGD93539.1 - 0.0057 16.4 0.0 0.0079 16.0 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferase class-I DUF4246 PF14033.6 EGD93540.1 - 1.6e-177 591.2 0.1 2.1e-177 590.8 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF4246) 2OG-FeII_Oxy_5 PF13759.6 EGD93540.1 - 0.0083 16.5 0.0 0.019 15.3 0.0 1.6 1 0 0 1 1 1 1 Putative 2OG-Fe(II) oxygenase Aminotran_1_2 PF00155.21 EGD93541.1 - 2.3e-72 244.2 0.0 2.7e-72 244.0 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II OMPdecase PF00215.24 EGD93543.1 - 2.1e-75 253.2 0.0 2.4e-75 253.0 0.0 1.0 1 0 0 1 1 1 1 Orotidine 5'-phosphate decarboxylase / HUMPS family MAPEG PF01124.18 EGD93544.1 - 6.3e-24 84.3 3.6 8.7e-24 83.9 3.6 1.2 1 0 0 1 1 1 1 MAPEG family MBOAT PF03062.19 EGD93545.1 - 1.1e-24 87.5 15.8 2e-24 86.6 15.8 1.5 1 1 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family MBOAT_2 PF13813.6 EGD93545.1 - 0.0071 16.6 2.6 0.021 15.1 2.6 1.8 1 0 0 1 1 1 1 Membrane bound O-acyl transferase family DUF2530 PF10745.9 EGD93545.1 - 2.2 8.6 8.9 2.2 8.6 0.0 3.7 3 1 0 4 4 4 0 Protein of unknown function (DUF2530) Orf78 PF06024.12 EGD93545.1 - 3.2 8.1 4.3 3.4 8.0 0.0 2.5 2 1 0 2 2 2 0 Orf78 (ac78) HTH_32 PF13565.6 EGD93547.1 - 2.4e-09 37.6 0.4 1.3e-07 32.1 0.0 2.1 1 1 1 2 2 2 1 Homeodomain-like domain HTH_Tnp_Tc3_2 PF01498.18 EGD93547.1 - 2.7e-07 30.7 0.6 5.9e-07 29.6 0.2 1.8 2 0 0 2 2 2 1 Transposase HTH_23 PF13384.6 EGD93547.1 - 3.4e-07 29.9 0.1 0.00065 19.4 0.0 2.3 2 0 0 2 2 2 2 Homeodomain-like domain Sigma70_r4_2 PF08281.12 EGD93547.1 - 8.2e-05 22.2 0.5 0.0063 16.2 0.0 2.8 3 0 0 3 3 3 1 Sigma-70, region 4 HTH_29 PF13551.6 EGD93547.1 - 0.00021 21.2 0.5 0.036 14.1 0.2 2.4 2 0 0 2 2 2 1 Winged helix-turn helix HTH_WhiA PF02650.14 EGD93547.1 - 0.00055 20.2 0.1 0.0046 17.3 0.1 2.1 2 0 0 2 2 2 1 WhiA C-terminal HTH domain HTH_24 PF13412.6 EGD93547.1 - 0.00057 19.4 0.5 1.3 8.7 0.1 2.9 2 1 0 2 2 2 2 Winged helix-turn-helix DNA-binding HTH_38 PF13936.6 EGD93547.1 - 0.0016 18.2 1.8 0.25 11.2 0.1 2.6 2 1 0 2 2 2 2 Helix-turn-helix domain HTH_20 PF12840.7 EGD93547.1 - 0.0023 17.9 0.0 1.4 9.0 0.0 2.2 2 0 0 2 2 2 2 Helix-turn-helix domain HTH_IclR PF09339.10 EGD93547.1 - 0.013 15.2 0.1 0.17 11.7 0.0 2.2 2 0 0 2 2 2 0 IclR helix-turn-helix domain Sigma70_r4 PF04545.16 EGD93547.1 - 0.029 13.9 0.0 0.15 11.6 0.0 2.0 2 1 0 2 2 2 0 Sigma-70, region 4 HTH_7 PF02796.15 EGD93547.1 - 0.04 14.0 4.8 0.25 11.4 2.4 2.8 2 1 0 2 2 2 0 Helix-turn-helix domain of resolvase HTH_28 PF13518.6 EGD93547.1 - 0.042 14.0 0.3 1.4 9.1 0.1 2.5 2 0 0 2 2 2 0 Helix-turn-helix domain TrmB PF01978.19 EGD93547.1 - 0.062 13.2 0.1 13 5.7 0.0 2.3 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB HTH_AsnC-type PF13404.6 EGD93547.1 - 0.084 12.7 0.1 5.8 6.8 0.0 2.4 2 0 0 2 2 2 0 AsnC-type helix-turn-helix domain WD40 PF00400.32 EGD93548.1 - 2e-32 110.7 31.0 1.3e-06 29.0 1.7 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EGD93548.1 - 1.5e-18 66.9 0.1 0.00013 22.2 0.0 5.2 3 1 1 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Frtz PF11768.8 EGD93548.1 - 0.059 11.7 0.0 0.18 10.1 0.0 1.7 1 1 0 1 1 1 0 WD repeat-containing and planar cell polarity effector protein Fritz RNase_PH PF01138.21 EGD93549.1 - 7.1e-19 68.6 0.0 1.5e-18 67.6 0.0 1.5 2 0 0 2 2 2 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 EGD93549.1 - 2.3e-08 33.9 0.2 8.4e-08 32.1 0.1 2.0 2 0 0 2 2 2 1 3' exoribonuclease family, domain 2 PhoLip_ATPase_C PF16212.5 EGD93550.1 - 9e-83 277.8 18.3 9e-83 277.8 18.3 2.4 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EGD93550.1 - 1.3e-26 92.1 8.1 4.2e-26 90.4 8.1 2.0 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Cation_ATPase PF13246.6 EGD93550.1 - 2.2e-12 46.9 0.0 3.6e-11 43.0 0.0 2.8 2 1 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 EGD93550.1 - 3.9e-12 46.9 0.2 1e-07 32.5 0.0 3.1 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 EGD93550.1 - 3e-07 30.1 0.0 8.3e-07 28.7 0.0 1.7 1 1 0 1 1 1 1 E1-E2 ATPase Hydrolase_3 PF08282.12 EGD93550.1 - 0.00097 18.9 0.2 0.0049 16.6 0.2 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase GP38 PF05268.11 EGD93550.1 - 0.74 9.4 5.6 1.6 8.3 5.6 1.5 1 0 0 1 1 1 0 Phage tail fibre adhesin Gp38 DNA_pol_B_thumb PF14791.6 EGD93551.1 - 2.7e-22 78.7 0.5 1.5e-21 76.4 0.2 2.4 3 0 0 3 3 3 1 DNA polymerase beta thumb DNA_pol_lambd_f PF10391.9 EGD93551.1 - 3.8e-18 65.0 0.8 7.7e-18 64.1 0.8 1.5 1 0 0 1 1 1 1 Fingers domain of DNA polymerase lambda DNA_pol_B_palm PF14792.6 EGD93551.1 - 4.1e-18 65.6 0.0 3.9e-15 56.0 0.0 2.5 2 0 0 2 2 2 2 DNA polymerase beta palm HHH_8 PF14716.6 EGD93551.1 - 7.8e-10 39.0 0.0 2e-09 37.7 0.0 1.7 1 0 0 1 1 1 1 Helix-hairpin-helix domain HHH_5 PF14520.6 EGD93551.1 - 0.035 14.7 0.0 0.13 12.9 0.0 1.9 2 0 0 2 2 2 0 Helix-hairpin-helix domain Peptidase_S8 PF00082.22 EGD93553.1 - 2.6e-34 118.8 12.5 4.9e-34 117.9 12.5 1.4 1 0 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 EGD93553.1 - 9.7e-18 64.6 0.2 1.6e-17 63.9 0.2 1.4 1 0 0 1 1 1 1 Peptidase inhibitor I9 NicO PF03824.16 EGD93554.1 - 4e-55 187.2 24.9 5.1e-53 180.2 8.0 2.5 3 0 0 3 3 3 2 High-affinity nickel-transport protein Peptidase_M14 PF00246.24 EGD93555.1 - 1.9e-72 244.5 0.0 2.6e-72 244.1 0.0 1.2 1 0 0 1 1 1 1 Zinc carboxypeptidase SET PF00856.28 EGD93556.1 - 1.6e-15 57.9 0.4 2.3e-14 54.1 0.4 2.2 1 1 0 1 1 1 1 SET domain SAF PF08666.12 EGD93556.1 - 0.018 15.7 0.0 11 6.7 0.0 2.4 2 0 0 2 2 2 0 SAF domain zf-RING_UBOX PF13445.6 EGD93557.1 - 3.2e-06 27.1 7.7 1.2e-05 25.2 1.2 3.0 2 1 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 EGD93557.1 - 5.3e-05 23.0 9.8 0.00021 21.1 1.8 3.4 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-NOSIP PF15906.5 EGD93557.1 - 9.4e-05 22.5 0.0 0.00018 21.6 0.0 1.5 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein zf-RING_5 PF14634.6 EGD93557.1 - 0.00015 21.7 4.8 0.00015 21.7 4.8 2.8 2 1 0 2 2 2 1 zinc-RING finger domain zf-RING_2 PF13639.6 EGD93557.1 - 0.00015 22.0 11.0 0.0087 16.4 5.0 3.1 2 1 1 3 3 3 2 Ring finger domain Atg14 PF10186.9 EGD93557.1 - 0.00035 19.8 10.3 0.00035 19.8 10.3 1.6 2 0 0 2 2 2 1 Vacuolar sorting 38 and autophagy-related subunit 14 Rtf2 PF04641.12 EGD93557.1 - 0.00045 19.7 2.2 0.00045 19.7 2.2 3.3 2 1 1 3 3 2 2 Rtf2 RING-finger zf-C3HC4_3 PF13920.6 EGD93557.1 - 0.0011 18.8 13.1 0.0017 18.2 2.0 3.3 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EGD93557.1 - 0.0029 17.4 8.5 0.0037 17.1 1.0 3.2 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_5 PF17121.5 EGD93557.1 - 0.0034 17.2 0.7 0.0093 15.8 0.7 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) FYVE PF01363.21 EGD93557.1 - 0.0038 17.3 13.6 0.021 15.0 5.9 3.7 2 2 1 3 3 3 1 FYVE zinc finger DUF1195 PF06708.11 EGD93557.1 - 0.03 14.1 0.1 0.054 13.3 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1195) Prok-RING_4 PF14447.6 EGD93557.1 - 0.077 12.9 14.0 0.039 13.8 5.6 3.5 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 zf-FLZ PF04570.14 EGD93557.1 - 0.39 10.2 3.3 4 7.0 0.1 3.3 3 0 0 3 3 3 0 zinc-finger of the FCS-type, C2-C2 Siva PF05458.12 EGD93557.1 - 0.46 10.1 5.9 0.13 11.9 1.2 2.1 2 0 0 2 2 2 0 Cd27 binding protein (Siva) zf-C3HC4_4 PF15227.6 EGD93557.1 - 0.68 10.1 13.4 0.44 10.8 6.1 3.4 2 1 1 3 3 3 0 zinc finger of C3HC4-type, RING IBR PF01485.21 EGD93557.1 - 2.1 8.6 13.0 1.4 9.2 2.3 3.4 2 1 1 3 3 3 0 IBR domain, a half RING-finger domain Zn_ribbon_17 PF17120.5 EGD93557.1 - 9.2 6.0 10.3 4.7 6.9 0.7 2.7 3 0 0 3 3 2 0 Zinc-ribbon, C4HC2 type Sec7 PF01369.20 EGD93558.1 - 4.1e-30 104.8 0.1 6.5e-30 104.2 0.1 1.3 1 0 0 1 1 1 1 Sec7 domain PH_9 PF15410.6 EGD93558.1 - 2.4e-06 27.9 0.0 5.7e-06 26.7 0.0 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain PH PF00169.29 EGD93558.1 - 1.2e-05 25.8 0.0 3.8e-05 24.1 0.0 2.0 2 0 0 2 2 2 1 PH domain RNA_pol_3_Rpc31 PF11705.8 EGD93558.1 - 1.6 8.9 5.0 0.36 11.0 0.9 2.0 2 0 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 BTB PF00651.31 EGD93559.1 - 0.0047 17.1 0.1 0.2 11.9 0.0 2.6 3 0 0 3 3 3 1 BTB/POZ domain SWIRM-assoc_2 PF16496.5 EGD93559.1 - 0.11 11.4 0.2 0.16 10.8 0.2 1.2 1 0 0 1 1 1 0 SWIRM-associated domain at the N-terminal Endonuclease_NS PF01223.23 EGD93560.1 - 7.5e-65 218.9 0.0 9.1e-65 218.6 0.0 1.0 1 0 0 1 1 1 1 DNA/RNA non-specific endonuclease Zip PF02535.22 EGD93561.1 - 5.4e-23 81.7 9.3 1.3e-22 80.5 9.1 1.7 1 1 0 1 1 1 1 ZIP Zinc transporter DUF2040 PF09745.9 EGD93562.1 - 5.6e-39 132.9 15.5 5.6e-39 132.9 15.5 3.9 3 1 0 3 3 3 1 Coiled-coil domain-containing protein 55 (DUF2040) Adhesin_P1_N PF18652.1 EGD93562.1 - 5.6 7.0 18.1 14 5.8 4.9 3.3 2 0 0 2 2 2 0 Adhesin P1 N-terminal domain Sedlin_N PF04628.13 EGD93563.1 - 3e-40 137.4 0.0 3.8e-40 137.1 0.0 1.1 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region Sybindin PF04099.12 EGD93563.1 - 0.0028 17.6 0.0 0.054 13.4 0.0 2.1 2 0 0 2 2 2 1 Sybindin-like family Herpes_capsid PF06112.11 EGD93563.1 - 0.0091 16.1 2.8 0.012 15.7 2.8 1.3 1 0 0 1 1 1 1 Gammaherpesvirus capsid protein NLBH PF05211.12 EGD93563.1 - 0.093 12.3 0.0 0.13 11.8 0.0 1.2 1 0 0 1 1 1 0 Neuraminyllactose-binding hemagglutinin precursor (NLBH) Isochorismatase PF00857.20 EGD93564.1 - 1.8e-24 86.8 0.0 1.2e-23 84.2 0.0 1.9 2 0 0 2 2 2 1 Isochorismatase family FAR1 PF03101.15 EGD93564.1 - 0.031 15.0 0.0 0.057 14.1 0.0 1.4 1 0 0 1 1 1 0 FAR1 DNA-binding domain Hexokinase_1 PF00349.21 EGD93565.1 - 3.1e-48 164.3 0.0 4.7e-48 163.7 0.0 1.3 1 0 0 1 1 1 1 Hexokinase Hexokinase_2 PF03727.16 EGD93565.1 - 1.4e-37 129.4 0.0 2.1e-37 128.9 0.0 1.2 1 0 0 1 1 1 1 Hexokinase NUDE_C PF04880.13 EGD93567.1 - 1.7e-57 194.7 11.2 1.7e-57 194.7 11.2 4.7 3 1 0 4 4 4 1 NUDE protein, C-terminal conserved region DUF16 PF01519.16 EGD93567.1 - 0.012 16.1 5.2 0.012 16.1 5.2 2.5 1 1 1 2 2 2 0 Protein of unknown function DUF16 CLZ PF16526.5 EGD93567.1 - 0.014 15.7 3.3 0.014 15.7 3.3 3.4 4 1 0 4 4 4 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels DUF1729 PF08354.10 EGD93567.1 - 0.042 12.8 0.5 0.062 12.2 0.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1729) PSII_Pbs27 PF13326.6 EGD93567.1 - 0.085 13.2 2.8 0.25 11.6 2.8 1.8 1 0 0 1 1 1 0 Photosystem II Pbs27 ZapB PF06005.12 EGD93567.1 - 0.37 11.3 33.4 0.24 11.8 8.0 4.9 2 1 2 4 4 4 0 Cell division protein ZapB ADIP PF11559.8 EGD93567.1 - 2.2 8.3 26.0 5.5 7.1 4.8 3.5 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding Chibby PF14645.6 EGD93567.1 - 8.6 6.8 12.9 6.8 7.1 4.1 3.1 1 1 0 2 2 2 0 Chibby family GAS PF13851.6 EGD93567.1 - 8.8 5.6 27.7 3.9 6.8 13.9 2.4 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding ACC_central PF08326.12 EGD93568.1 - 1.7e-282 939.0 0.0 2.1e-282 938.7 0.0 1.1 1 0 0 1 1 1 1 Acetyl-CoA carboxylase, central region Carboxyl_trans PF01039.22 EGD93568.1 - 2.4e-190 633.4 0.0 4.3e-190 632.5 0.0 1.4 2 0 0 2 2 2 1 Carboxyl transferase domain CPSase_L_D2 PF02786.17 EGD93568.1 - 7.2e-54 182.5 0.0 1.4e-53 181.6 0.0 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.22 EGD93568.1 - 2.7e-27 95.5 0.1 5.4e-27 94.5 0.1 1.6 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 EGD93568.1 - 9.4e-23 80.4 0.0 9.8e-20 70.7 0.0 2.9 2 0 0 2 2 2 2 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.22 EGD93568.1 - 2.4e-15 56.1 0.2 6.8e-15 54.7 0.0 1.9 2 0 0 2 2 2 1 Biotin-requiring enzyme Dala_Dala_lig_C PF07478.13 EGD93568.1 - 8e-05 22.3 0.0 0.00026 20.6 0.0 1.9 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp_3 PF02655.14 EGD93568.1 - 0.00017 21.7 0.0 0.00044 20.3 0.0 1.7 1 0 0 1 1 1 1 ATP-grasp domain Antiterm PF03589.13 EGD93568.1 - 0.052 13.9 0.0 0.82 10.0 0.0 2.8 2 0 0 2 2 2 0 Antitermination protein ATPgrasp_Ter PF15632.6 EGD93568.1 - 0.1 12.4 0.0 0.27 11.0 0.0 1.6 1 0 0 1 1 1 0 ATP-grasp in the biosynthetic pathway with Ter operon HeLo PF14479.6 EGD93569.1 - 4.9e-05 23.3 0.3 0.0028 17.5 0.3 2.4 1 1 0 1 1 1 1 Prion-inhibition and propagation Trypsin_2 PF13365.6 EGD93569.1 - 0.14 13.1 0.1 0.3 12.0 0.1 1.5 1 0 0 1 1 1 0 Trypsin-like peptidase domain RINGv PF12906.7 EGD93570.1 - 5.4e-16 58.4 10.1 9.4e-16 57.7 10.1 1.4 1 0 0 1 1 1 1 RING-variant domain zf-RING_2 PF13639.6 EGD93570.1 - 0.0037 17.5 8.8 0.0066 16.8 8.8 1.4 1 0 0 1 1 1 1 Ring finger domain zf-ANAPC11 PF12861.7 EGD93570.1 - 0.41 10.7 3.6 0.92 9.6 3.6 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Zf_RING PF16744.5 EGD93570.1 - 0.95 9.6 3.7 2 8.6 3.7 1.4 1 0 0 1 1 1 0 KIAA1045 RING finger zf-RING_4 PF14570.6 EGD93570.1 - 1.4 8.8 6.6 2.3 8.1 6.6 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Merozoite_SPAM PF07133.11 EGD93570.1 - 1.5 8.8 17.3 3.2 7.7 17.3 1.4 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) zf-C3HC4_3 PF13920.6 EGD93570.1 - 3.4 7.6 5.6 6.7 6.7 5.6 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) FANCL_C PF11793.8 EGD93570.1 - 4.2 7.6 6.7 9.1 6.5 6.7 1.5 1 0 0 1 1 1 0 FANCL C-terminal domain RR_TM4-6 PF06459.12 EGD93570.1 - 4.9 6.9 6.7 12 5.6 6.7 1.5 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 PET10 PF17316.2 EGD93571.1 - 1.3 8.5 7.4 6.6 6.2 3.1 2.5 1 1 1 2 2 2 0 Petite colonies protein 10 YtxH PF12732.7 EGD93571.1 - 2 9.0 3.9 27 5.4 0.1 3.9 4 1 0 4 4 4 0 YtxH-like protein Uso1_p115_C PF04871.13 EGD93571.1 - 4 7.8 6.3 1 9.8 0.3 2.7 2 1 0 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region TMEM208_SND2 PF05620.11 EGD93572.1 - 4e-54 182.9 0.0 4.5e-54 182.7 0.0 1.0 1 0 0 1 1 1 1 SRP-independent targeting protein 2/TMEM208 TPR_1 PF00515.28 EGD93573.1 - 5.4e-39 130.4 11.5 5.1e-06 26.1 0.0 8.8 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_2 PF07719.17 EGD93573.1 - 8.3e-33 109.8 19.5 0.00056 19.8 0.0 9.9 10 0 0 10 10 10 7 Tetratricopeptide repeat ANAPC3 PF12895.7 EGD93573.1 - 3.2e-30 104.2 22.5 5.8e-24 84.1 0.5 4.9 5 0 0 5 5 5 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.6 EGD93573.1 - 1.1e-24 85.9 7.7 1.1e-07 31.4 1.0 8.7 7 1 2 9 9 9 7 TPR repeat TPR_8 PF13181.6 EGD93573.1 - 5.4e-24 82.4 11.3 0.00095 19.2 0.5 9.3 9 0 0 9 9 9 5 Tetratricopeptide repeat TPR_19 PF14559.6 EGD93573.1 - 1.5e-22 79.9 15.5 4.4e-08 33.5 0.4 7.3 6 1 1 7 7 7 3 Tetratricopeptide repeat TPR_14 PF13428.6 EGD93573.1 - 5.3e-20 70.4 7.9 0.0021 18.7 0.1 9.5 7 1 2 9 9 9 5 Tetratricopeptide repeat TPR_16 PF13432.6 EGD93573.1 - 8.9e-19 67.9 10.5 7.6e-09 36.1 0.4 8.3 7 1 1 8 8 8 2 Tetratricopeptide repeat TPR_12 PF13424.6 EGD93573.1 - 2.4e-14 53.4 18.6 0.0029 17.9 0.2 8.3 6 3 1 7 7 7 4 Tetratricopeptide repeat TPR_17 PF13431.6 EGD93573.1 - 1.6e-12 46.9 11.4 0.011 16.1 0.0 9.1 9 0 0 9 9 9 2 Tetratricopeptide repeat TPR_7 PF13176.6 EGD93573.1 - 2.3e-06 27.2 10.6 2.6 8.2 0.0 8.0 9 0 0 9 9 8 2 Tetratricopeptide repeat TPR_9 PF13371.6 EGD93573.1 - 8.6e-06 25.8 0.8 0.057 13.6 0.0 4.2 2 1 3 5 5 5 2 Tetratricopeptide repeat TPR_6 PF13174.6 EGD93573.1 - 6.8e-05 23.3 15.8 2.2 9.1 0.1 7.9 10 0 0 10 10 9 1 Tetratricopeptide repeat ChAPs PF09295.10 EGD93573.1 - 0.0054 15.8 0.2 0.29 10.1 0.0 2.3 2 0 0 2 2 2 1 ChAPs (Chs5p-Arf1p-binding proteins) TPR_MalT PF17874.1 EGD93573.1 - 0.04 13.3 1.5 3.1 7.1 0.0 3.6 3 1 1 4 4 4 0 MalT-like TPR region PPTA PF01239.22 EGD93573.1 - 0.048 13.4 0.2 0.14 11.9 0.2 1.9 1 0 0 1 1 1 0 Protein prenyltransferase alpha subunit repeat TPR_21 PF09976.9 EGD93573.1 - 1.8 8.2 7.3 1.8 8.2 0.4 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat-like domain NAM-associated PF14303.6 EGD93573.1 - 8.2 7.1 10.8 0.87 10.3 2.4 2.6 2 0 0 2 2 2 0 No apical meristem-associated C-terminal domain Acyltransferase PF01553.21 EGD93574.1 - 2.6e-30 104.8 0.0 4.5e-30 104.0 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase ACPS PF01648.20 EGD93575.1 - 8.2e-14 51.7 0.0 2.5e-13 50.2 0.0 1.8 2 0 0 2 2 2 1 4'-phosphopantetheinyl transferase superfamily SNO PF01174.19 EGD93577.1 - 9.8e-53 178.8 0.0 5.1e-42 143.9 0.0 2.1 1 1 0 2 2 2 2 SNO glutamine amidotransferase family GATase_3 PF07685.14 EGD93577.1 - 2.2e-08 34.0 0.0 7.1e-07 29.0 0.0 2.2 2 0 0 2 2 2 1 CobB/CobQ-like glutamine amidotransferase domain GATase PF00117.28 EGD93577.1 - 0.0019 18.0 0.0 0.019 14.7 0.0 2.3 1 1 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_S51 PF03575.17 EGD93577.1 - 0.0053 16.4 0.0 0.0075 15.9 0.0 1.2 1 0 0 1 1 1 1 Peptidase family S51 DJ-1_PfpI PF01965.24 EGD93577.1 - 0.0081 16.0 0.0 0.015 15.1 0.0 1.5 1 0 0 1 1 1 1 DJ-1/PfpI family RRM_1 PF00076.22 EGD93578.1 - 1.5e-14 53.5 0.0 2.2e-14 53.0 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup54 PF13874.6 EGD93579.1 - 0.0018 18.4 0.8 0.0018 18.4 0.8 2.3 2 1 0 2 2 2 1 Nucleoporin complex subunit 54 Rotamase PF00639.21 EGD93581.1 - 8.6e-24 84.3 0.1 1.2e-23 83.9 0.1 1.2 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_3 PF13616.6 EGD93581.1 - 7.8e-16 58.7 0.0 1e-15 58.3 0.0 1.2 1 0 0 1 1 1 1 PPIC-type PPIASE domain WW PF00397.26 EGD93581.1 - 3.6e-09 36.5 0.4 3.6e-09 36.5 0.4 1.7 2 0 0 2 2 2 1 WW domain Rotamase_2 PF13145.6 EGD93581.1 - 5.5e-05 24.0 0.0 7.2e-05 23.6 0.0 1.2 1 0 0 1 1 1 1 PPIC-type PPIASE domain WW_1 PF18507.1 EGD93581.1 - 0.029 14.1 0.1 0.048 13.4 0.1 1.4 1 0 0 1 1 1 0 WW domain Pro_3_hydrox_C PF05373.11 EGD93582.1 - 0.01 15.9 0.0 0.031 14.4 0.0 1.8 1 0 0 1 1 1 0 L-proline 3-hydroxylase, C-terminal TFIIS_C PF01096.18 EGD93583.1 - 8.4e-15 54.3 2.8 8.4e-15 54.3 2.8 2.9 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) RNA_POL_M_15KD PF02150.16 EGD93583.1 - 3.7e-12 45.9 1.0 3.7e-12 45.9 1.0 2.9 3 0 0 3 3 3 1 RNA polymerases M/15 Kd subunit GFA PF04828.14 EGD93583.1 - 0.014 15.7 10.1 0.33 11.3 0.6 2.7 1 1 2 3 3 3 0 Glutathione-dependent formaldehyde-activating enzyme Lar_restr_allev PF14354.6 EGD93583.1 - 0.045 14.1 2.5 0.045 14.1 2.5 2.3 2 1 0 2 2 2 0 Restriction alleviation protein Lar DZR PF12773.7 EGD93583.1 - 0.39 10.8 13.3 1.9 8.6 3.1 2.5 2 2 0 2 2 2 0 Double zinc ribbon Ribosomal_L14 PF00238.19 EGD93584.1 - 1.1e-47 161.1 1.5 1.2e-47 160.9 1.5 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e Dak1_2 PF13684.6 EGD93584.1 - 0.097 11.7 0.1 0.11 11.5 0.1 1.1 1 0 0 1 1 1 0 Dihydroxyacetone kinase family SET PF00856.28 EGD93585.1 - 5.8e-09 36.6 0.0 1.5e-08 35.3 0.0 1.8 1 0 0 1 1 1 1 SET domain HypA PF01155.19 EGD93585.1 - 0.083 12.9 0.3 0.083 12.9 0.3 2.0 3 0 0 3 3 3 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DUF4519 PF15012.6 EGD93585.1 - 0.27 11.4 2.3 2.7 8.2 0.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4519) Med19 PF10278.9 EGD93587.1 - 0.062 13.2 0.8 0.062 13.2 0.8 1.9 2 0 0 2 2 2 0 Mediator of RNA pol II transcription subunit 19 SNARE PF05739.19 EGD93587.1 - 0.32 11.0 0.7 0.69 10.0 0.7 1.5 1 0 0 1 1 1 0 SNARE domain DEAD PF00270.29 EGD93588.1 - 1.2e-31 109.8 0.0 2.2e-31 109.0 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EGD93588.1 - 9.8e-20 71.0 0.2 3.6e-17 62.7 0.1 2.7 2 1 0 2 2 2 2 Helicase conserved C-terminal domain ResIII PF04851.15 EGD93588.1 - 5.9e-05 23.1 0.1 0.0012 18.9 0.0 2.7 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit SNF2_N PF00176.23 EGD93588.1 - 0.12 11.0 0.0 0.19 10.4 0.0 1.2 1 0 0 1 1 1 0 SNF2 family N-terminal domain Anillin PF08174.11 EGD93589.1 - 4.7e-09 36.8 0.0 1.8e-08 34.9 0.0 2.1 1 0 0 1 1 1 1 Cell division protein anillin PH PF00169.29 EGD93589.1 - 1.8e-07 31.6 0.0 5.7e-07 30.0 0.0 1.9 1 0 0 1 1 1 1 PH domain DUF3439 PF11921.8 EGD93589.1 - 2.6 8.0 4.6 10 6.1 0.2 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) PseudoU_synth_1 PF01416.20 EGD93590.1 - 1.4e-10 41.6 0.0 3.4e-08 33.9 0.0 2.8 3 0 0 3 3 3 2 tRNA pseudouridine synthase ATP_bind_2 PF03668.15 EGD93590.1 - 0.026 13.8 0.0 0.048 12.9 0.0 1.3 1 0 0 1 1 1 0 P-loop ATPase protein family TFIIE_alpha PF02002.17 EGD93591.1 - 2.9e-19 68.8 0.0 6.5e-19 67.7 0.0 1.6 1 0 0 1 1 1 1 TFIIE alpha subunit HTH_Crp_2 PF13545.6 EGD93591.1 - 0.007 16.3 0.6 0.013 15.5 0.6 1.4 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain zinc-ribbons_6 PF07191.12 EGD93591.1 - 0.019 14.9 0.2 0.035 14.1 0.2 1.4 1 0 0 1 1 1 0 zinc-ribbons zf_UBZ PF18439.1 EGD93591.1 - 0.042 13.5 1.1 0.98 9.1 0.1 2.4 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger SR1P PF13790.6 EGD93591.1 - 0.18 12.0 3.6 0.24 11.5 0.3 2.3 2 0 0 2 2 2 0 SR1 protein Gin PF10764.9 EGD93591.1 - 0.23 11.4 0.6 5 7.2 0.1 2.3 2 0 0 2 2 2 0 Inhibitor of sigma-G Gin TrkH PF02386.16 EGD93592.1 - 2.2e-137 458.6 11.5 3.3e-134 448.1 4.8 2.0 2 0 0 2 2 2 2 Cation transport protein NnrU PF07298.11 EGD93592.1 - 0.41 10.1 4.8 0.15 11.6 1.4 1.9 2 0 0 2 2 2 0 NnrU protein MFS_1 PF07690.16 EGD93593.1 - 2.1e-16 59.8 53.4 2.1e-16 59.8 53.4 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily PALP PF00291.25 EGD93594.1 - 2.1e-46 158.7 0.3 2.8e-46 158.3 0.3 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme DUF3517 PF12030.8 EGD93595.1 - 6.7e-90 301.4 1.0 1.1e-89 300.7 1.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3517) UCH PF00443.29 EGD93595.1 - 4.1e-41 141.2 0.0 7.4e-41 140.3 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EGD93595.1 - 2.1e-22 80.1 0.0 4.4e-22 79.1 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase p47_phox_C PF08944.11 EGD93595.1 - 0.057 12.8 0.7 0.17 11.3 0.7 1.8 1 0 0 1 1 1 0 NADPH oxidase subunit p47Phox, C terminal domain Peptidase_C98 PF15499.6 EGD93595.1 - 0.13 11.7 0.1 0.27 10.7 0.1 1.4 1 0 0 1 1 1 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase ADD_ATRX PF17981.1 EGD93595.1 - 0.15 12.0 0.1 0.52 10.2 0.1 1.8 2 0 0 2 2 2 0 Cysteine Rich ADD domain RNase_P_pop3 PF08228.11 EGD93596.1 - 7.9e-05 22.8 0.0 0.00015 21.8 0.0 1.4 1 1 0 1 1 1 1 RNase P subunit Pop3 CD34_antigen PF06365.12 EGD93596.1 - 0.092 12.3 0.0 0.12 11.9 0.0 1.2 1 0 0 1 1 1 0 CD34/Podocalyxin family Mac PF12464.8 EGD93597.1 - 8.5e-11 41.9 0.1 1.3e-10 41.3 0.1 1.3 1 0 0 1 1 1 1 Maltose acetyltransferase Hexapep PF00132.24 EGD93597.1 - 2.9e-10 39.4 11.6 2.8e-09 36.3 4.6 3.2 3 0 0 3 3 3 2 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 EGD93597.1 - 9.8e-09 34.8 10.8 4.2e-08 32.8 4.1 2.7 3 0 0 3 3 3 2 Hexapeptide repeat of succinyl-transferase Ank_2 PF12796.7 EGD93598.1 - 1.4e-40 137.7 3.9 1e-11 45.3 0.0 5.5 3 2 4 7 7 7 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EGD93598.1 - 2.4e-37 126.8 6.8 2e-08 34.6 0.1 8.0 2 2 7 9 9 9 8 Ankyrin repeats (many copies) Ank_5 PF13857.6 EGD93598.1 - 3.8e-32 109.9 9.4 2.2e-09 37.4 0.1 6.6 3 2 3 6 6 6 6 Ankyrin repeats (many copies) Ank PF00023.30 EGD93598.1 - 1.7e-30 104.1 7.4 1.5e-06 28.4 0.0 8.9 8 1 1 9 9 9 6 Ankyrin repeat Ank_3 PF13606.6 EGD93598.1 - 1.8e-28 95.4 8.4 6e-06 26.2 0.0 9.0 9 0 0 9 9 9 6 Ankyrin repeat AIRC PF00731.20 EGD93599.1 - 2.7e-59 199.0 1.7 5.3e-59 198.0 1.7 1.5 1 0 0 1 1 1 1 AIR carboxylase ATP-grasp PF02222.22 EGD93599.1 - 6.1e-52 175.6 0.0 1.3e-51 174.6 0.0 1.6 1 0 0 1 1 1 1 ATP-grasp domain PurK_C PF17769.1 EGD93599.1 - 1.2e-18 66.6 0.0 2.8e-18 65.4 0.0 1.7 1 0 0 1 1 1 1 Phosphoribosylaminoimidazole carboxylase C-terminal domain CPSase_L_D2 PF02786.17 EGD93599.1 - 0.00013 21.5 0.2 0.00049 19.6 0.0 2.0 2 0 0 2 2 2 1 Carbamoyl-phosphate synthase L chain, ATP binding domain PrpR_N PF06506.11 EGD93599.1 - 0.00066 19.3 0.7 0.0052 16.4 0.1 2.4 2 0 0 2 2 2 1 Propionate catabolism activator AlaDh_PNT_C PF01262.21 EGD93599.1 - 0.00088 18.6 0.2 0.0018 17.6 0.2 1.5 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Dala_Dala_lig_C PF07478.13 EGD93599.1 - 0.023 14.2 0.0 0.45 10.0 0.0 2.3 1 1 0 1 1 1 0 D-ala D-ala ligase C-terminus CoA_binding_2 PF13380.6 EGD93599.1 - 0.1 13.1 1.0 26 5.4 0.0 3.4 2 1 1 3 3 3 0 CoA binding domain SCA7 PF08313.12 EGD93600.1 - 5.6e-31 106.2 0.8 5.6e-31 106.2 0.8 2.1 2 0 0 2 2 2 1 SCA7, zinc-binding domain DUF2151 PF10221.9 EGD93600.1 - 0.098 11.2 7.5 0.13 10.8 7.5 1.1 1 0 0 1 1 1 0 Cell cycle and development regulator Neugrin PF06413.11 EGD93600.1 - 0.35 10.8 7.0 0.56 10.2 7.0 1.4 1 0 0 1 1 1 0 Neugrin DUF4551 PF15087.6 EGD93600.1 - 1.3 7.7 5.6 1.7 7.4 5.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) CDC45 PF02724.14 EGD93600.1 - 1.4 7.1 7.8 1.9 6.6 7.8 1.2 1 0 0 1 1 1 0 CDC45-like protein DUF913 PF06025.12 EGD93600.1 - 1.7 7.5 6.3 2.8 6.8 6.3 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) ATP-synt_Eps PF04627.13 EGD93600.1 - 1.7 8.7 6.7 4.1 7.5 6.7 1.6 1 0 0 1 1 1 0 Mitochondrial ATP synthase epsilon chain mRNA_cap_enzyme PF01331.19 EGD93601.1 - 6.2e-52 176.3 0.4 8.5e-52 175.8 0.4 1.2 1 0 0 1 1 1 1 mRNA capping enzyme, catalytic domain mRNA_cap_C PF03919.15 EGD93601.1 - 7.6e-36 123.0 0.0 1.5e-35 122.1 0.0 1.5 1 0 0 1 1 1 1 mRNA capping enzyme, C-terminal domain DNA_ligase_A_M PF01068.21 EGD93601.1 - 1.2e-08 34.9 0.6 7.9e-07 28.9 0.2 2.4 1 1 1 2 2 2 2 ATP dependent DNA ligase domain DNA_ligase_A_M PF01068.21 EGD93602.1 - 2e-59 200.7 1.9 1.6e-57 194.4 0.4 2.7 2 1 0 2 2 2 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 EGD93602.1 - 5.6e-33 114.7 0.1 2.1e-32 112.8 0.1 2.0 1 1 0 1 1 1 1 DNA ligase N terminus DNA_ligase_A_C PF04679.15 EGD93602.1 - 1.1e-27 96.5 0.0 5.2e-27 94.3 0.0 2.3 2 0 0 2 2 2 1 ATP dependent DNA ligase C terminal region RNA_ligase PF09414.10 EGD93602.1 - 6.8e-06 26.5 0.1 1.2e-05 25.7 0.1 1.4 1 0 0 1 1 1 1 RNA ligase CFEM PF05730.11 EGD93603.1 - 5.2e-10 39.3 4.7 7.4e-10 38.8 4.7 1.2 1 0 0 1 1 1 1 CFEM domain PT PF04886.12 EGD93603.1 - 0.00027 20.4 12.7 0.0064 16.0 6.4 2.9 2 0 0 2 2 2 2 PT repeat Catalase PF00199.19 EGD93604.1 - 3.1e-173 576.3 0.1 3.7e-173 576.0 0.1 1.1 1 0 0 1 1 1 1 Catalase Catalase-rel PF06628.12 EGD93604.1 - 0.027 14.7 0.0 0.081 13.1 0.0 1.8 1 0 0 1 1 1 0 Catalase-related immune-responsive GMC_oxred_N PF00732.19 EGD93605.1 - 1.4e-47 162.5 0.0 1.8e-47 162.2 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EGD93605.1 - 6.5e-32 111.0 0.0 1e-31 110.4 0.0 1.3 1 0 0 1 1 1 1 GMC oxidoreductase Pyr_redox_3 PF13738.6 EGD93605.1 - 0.0043 16.3 0.1 2.1 7.5 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EGD93605.1 - 0.0046 17.2 0.0 0.013 15.7 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 EGD93605.1 - 0.0081 15.2 0.4 0.014 14.5 0.4 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein FAD_binding_2 PF00890.24 EGD93605.1 - 0.021 13.9 1.9 0.051 12.6 1.8 1.6 2 0 0 2 2 2 0 FAD binding domain DAO PF01266.24 EGD93605.1 - 0.026 14.1 0.0 0.041 13.5 0.0 1.4 1 0 0 1 1 1 0 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EGD93605.1 - 0.041 13.1 0.1 0.072 12.3 0.1 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EGD93605.1 - 0.057 12.1 0.6 0.08 11.6 0.6 1.1 1 0 0 1 1 1 0 HI0933-like protein Trp_halogenase PF04820.14 EGD93605.1 - 0.085 11.7 0.5 0.12 11.1 0.5 1.2 1 0 0 1 1 1 0 Tryptophan halogenase FAD_oxidored PF12831.7 EGD93605.1 - 0.22 10.8 2.0 0.32 10.3 2.0 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase FPN1 PF06963.12 EGD93606.1 - 8.2e-108 360.8 12.6 8.4e-107 357.4 12.6 1.9 1 1 0 1 1 1 1 Ferroportin1 (FPN1) Transgly_assoc PF04226.13 EGD93606.1 - 6 7.2 7.6 20 5.5 1.0 3.7 3 0 0 3 3 3 0 Transglycosylase associated protein TTRAP PF14203.6 EGD93607.1 - 0.032 14.2 0.5 0.56 10.2 0.1 3.2 3 0 0 3 3 3 0 Putative tranposon-transfer assisting protein DCB PF16213.5 EGD93607.1 - 0.45 10.2 6.1 5.2 6.7 0.1 3.7 4 0 0 4 4 4 0 Dimerisation and cyclophilin-binding domain of Mon2 eIF-5_eIF-2B PF01873.17 EGD93608.1 - 4.9e-39 132.8 0.0 8.6e-39 132.0 0.0 1.4 1 0 0 1 1 1 1 Domain found in IF2B/IF5 W2 PF02020.18 EGD93608.1 - 1.6e-21 76.2 0.4 1.6e-21 76.2 0.4 2.4 3 0 0 3 3 3 1 eIF4-gamma/eIF5/eIF2-epsilon PcfK PF14058.6 EGD93608.1 - 0.19 12.0 0.0 0.19 12.0 0.0 3.0 3 0 0 3 3 3 0 PcfK-like protein HK PF02110.15 EGD93609.1 - 1.5e-76 257.1 0.3 1.5e-76 257.1 0.3 1.5 2 0 0 2 2 2 1 Hydroxyethylthiazole kinase family TMP-TENI PF02581.17 EGD93609.1 - 3.4e-59 199.2 3.4 3.9e-59 199.0 2.6 1.5 2 0 0 2 2 2 1 Thiamine monophosphate synthase QRPTase_C PF01729.19 EGD93609.1 - 0.00044 20.1 0.0 0.0011 18.8 0.0 1.6 1 1 0 1 1 1 1 Quinolinate phosphoribosyl transferase, C-terminal domain PfkB PF00294.24 EGD93609.1 - 0.0043 16.4 0.0 0.0082 15.5 0.0 1.4 1 0 0 1 1 1 1 pfkB family carbohydrate kinase NMO PF03060.15 EGD93609.1 - 0.25 10.7 7.3 0.062 12.7 3.5 1.9 2 1 0 2 2 2 0 Nitronate monooxygenase Isochorismatase PF00857.20 EGD93610.1 - 2.1e-27 96.4 0.0 2.7e-27 96.1 0.0 1.1 1 0 0 1 1 1 1 Isochorismatase family Trimer_CC PF08954.11 EGD93614.1 - 0.43 10.2 3.0 0.26 10.9 0.1 2.1 2 0 0 2 2 2 0 Trimerisation motif Lipase_GDSL_2 PF13472.6 EGD93615.1 - 1.2e-22 81.2 0.0 2.5e-22 80.1 0.0 1.6 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 EGD93615.1 - 2.3e-16 60.4 0.0 3.1e-16 60.0 0.0 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Voltage_CLC PF00654.20 EGD93616.1 - 4e-90 302.6 23.9 5.7e-90 302.1 20.2 2.0 2 0 0 2 2 2 2 Voltage gated chloride channel DHFR_1 PF00186.19 EGD93617.1 - 5.3e-18 65.2 0.0 2.6e-09 37.0 0.0 3.3 3 1 0 3 3 3 3 Dihydrofolate reductase TPALS PF18178.1 EGD93617.1 - 0.053 13.0 0.0 0.087 12.2 0.0 1.2 1 0 0 1 1 1 0 TIR- and PNP-associating SLOG family Med22 PF06179.12 EGD93618.1 - 6.5e-20 71.3 1.6 7.9e-20 71.0 1.6 1.1 1 0 0 1 1 1 1 Surfeit locus protein 5 subunit 22 of Mediator complex PrmC_N PF17827.1 EGD93618.1 - 0.02 15.5 2.3 0.14 12.8 2.3 2.0 1 1 0 1 1 1 0 PrmC N-terminal domain Cwf_Cwc_15 PF04889.12 EGD93620.1 - 1.4e-87 293.5 16.6 1.7e-87 293.3 16.6 1.0 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein MFAP1 PF06991.11 EGD93620.1 - 0.015 15.1 14.0 0.021 14.7 14.0 1.5 1 0 0 1 1 1 0 Microfibril-associated/Pre-mRNA processing DUF3752 PF12572.8 EGD93620.1 - 0.055 14.0 13.9 0.073 13.6 13.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3752) DUF4636 PF15468.6 EGD93620.1 - 0.22 11.2 3.5 0.3 10.8 3.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4636) SDA1 PF05285.12 EGD93620.1 - 0.48 9.8 19.4 0.55 9.6 19.4 1.1 1 0 0 1 1 1 0 SDA1 PA26 PF04636.13 EGD93620.1 - 1.3 7.9 4.0 1.5 7.6 4.0 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) CDC45 PF02724.14 EGD93620.1 - 2.7 6.2 14.9 2.9 6.1 14.9 1.1 1 0 0 1 1 1 0 CDC45-like protein Hid1 PF12722.7 EGD93620.1 - 3.9 5.5 5.1 4.4 5.3 5.1 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Presenilin PF01080.17 EGD93620.1 - 7.6 5.2 6.7 9.1 4.9 6.7 1.1 1 0 0 1 1 1 0 Presenilin Tmemb_170 PF10190.9 EGD93621.1 - 1.2e-23 83.4 9.3 1.4e-23 83.2 9.3 1.1 1 0 0 1 1 1 1 Putative transmembrane protein 170 ICMT PF04140.14 EGD93623.1 - 3e-29 101.3 0.3 3e-29 101.3 0.3 2.1 2 0 0 2 2 2 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.13 EGD93623.1 - 3.2e-11 43.6 3.4 3.2e-11 43.6 3.4 1.9 2 1 1 3 3 3 1 Phospholipid methyltransferase DUF1295 PF06966.12 EGD93623.1 - 1.4e-05 24.7 0.5 2.4e-05 24.0 0.5 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) 7tm_3 PF00003.22 EGD93623.1 - 0.091 12.5 9.5 0.13 12.0 9.5 1.2 1 0 0 1 1 1 0 7 transmembrane sweet-taste receptor of 3 GCPR Neugrin PF06413.11 EGD93624.1 - 2.6e-09 37.4 3.8 4.7e-09 36.6 3.8 1.5 1 1 0 1 1 1 1 Neugrin MRP-L20 PF12824.7 EGD93624.1 - 5.2e-08 33.2 6.6 1.2e-07 32.0 6.6 1.7 1 0 0 1 1 1 1 Mitochondrial ribosomal protein subunit L20 HTH_DeoR PF08220.12 EGD93624.1 - 0.04 13.7 0.0 0.1 12.3 0.0 1.7 1 0 0 1 1 1 0 DeoR-like helix-turn-helix domain HTH_7 PF02796.15 EGD93624.1 - 0.092 12.8 0.2 0.68 10.1 0.0 2.6 3 1 0 3 3 3 0 Helix-turn-helix domain of resolvase Rgp1 PF08737.10 EGD93625.1 - 4.2e-135 451.1 0.0 9.1e-135 450.0 0.0 1.6 1 0 0 1 1 1 1 Rgp1 Arrestin_N PF00339.29 EGD93625.1 - 2.1e-05 24.6 0.0 6.1e-05 23.1 0.0 1.8 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 EGD93625.1 - 0.001 19.5 0.0 0.29 11.6 0.0 3.1 3 0 0 3 3 3 2 Arrestin (or S-antigen), C-terminal domain Mob1_phocein PF03637.17 EGD93626.1 - 1.5e-72 243.1 0.1 1.9e-72 242.8 0.1 1.0 1 0 0 1 1 1 1 Mob1/phocein family OSCP PF00213.18 EGD93627.1 - 4.1e-40 137.7 1.4 6.1e-40 137.1 1.4 1.2 1 0 0 1 1 1 1 ATP synthase delta (OSCP) subunit ATG16 PF08614.11 EGD93628.1 - 0.009 16.3 0.5 0.009 16.3 0.5 1.7 2 0 0 2 2 2 1 Autophagy protein 16 (ATG16) Sugarporin_N PF11471.8 EGD93628.1 - 0.041 13.9 2.7 0.076 13.0 2.7 1.4 1 0 0 1 1 1 0 Maltoporin periplasmic N-terminal extension Bromodomain PF00439.25 EGD93629.1 - 1.3e-06 28.3 0.0 0.0002 21.4 0.0 2.3 2 0 0 2 2 2 2 Bromodomain Diphthamide_syn PF01866.17 EGD93630.1 - 3.9e-119 397.6 0.0 5e-119 397.2 0.0 1.1 1 0 0 1 1 1 1 Putative diphthamide synthesis protein HMGL-like PF00682.19 EGD93631.1 - 1.5e-44 152.5 0.0 1.8e-44 152.3 0.0 1.0 1 0 0 1 1 1 1 HMGL-like PE PF00934.20 EGD93631.1 - 0.3 11.4 1.6 0.48 10.8 0.4 2.1 2 1 0 2 2 2 0 PE family DUF1674 PF07896.12 EGD93632.1 - 1.9e-20 73.1 4.6 1.9e-20 73.1 4.6 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF1674) Msap1 PF17077.5 EGD93632.1 - 0.17 11.0 1.7 0.19 10.8 1.7 1.1 1 0 0 1 1 1 0 Mitotic spindle associated protein SHE1 MSA_2 PF00985.17 EGD93632.1 - 0.18 12.2 2.5 0.2 12.0 2.5 1.1 1 0 0 1 1 1 0 Merozoite Surface Antigen 2 (MSA-2) family ORC6 PF05460.13 EGD93632.1 - 0.49 9.6 4.8 0.51 9.6 4.8 1.0 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) DprA_WH PF17782.1 EGD93632.1 - 6.1 7.0 6.4 3.9 7.6 0.3 2.2 2 0 0 2 2 2 0 DprA winged helix domain Aminotran_3 PF00202.21 EGD93633.1 - 1.5e-113 379.5 0.0 2e-113 379.1 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.21 EGD93633.1 - 4.5e-05 22.8 0.0 0.00018 20.8 0.0 1.8 1 1 0 1 1 1 1 Aminotransferase class I and II Abhydrolase_3 PF07859.13 EGD93634.1 - 3.2e-33 115.4 0.0 1.3e-22 80.7 0.0 2.7 2 0 0 2 2 2 2 alpha/beta hydrolase fold Lipase_3 PF01764.25 EGD93634.1 - 0.093 12.6 0.0 0.25 11.2 0.0 1.6 1 0 0 1 1 1 0 Lipase (class 3) CLN3 PF02487.17 EGD93635.1 - 4.7e-161 536.3 1.2 5.4e-161 536.1 1.2 1.0 1 0 0 1 1 1 1 CLN3 protein Rxt3 PF08642.10 EGD93636.1 - 3.8e-46 157.0 1.7 2e-45 154.6 0.0 2.8 2 0 0 2 2 2 1 Histone deacetylation protein Rxt3 LCCL PF03815.19 EGD93636.1 - 0.00042 20.4 0.0 0.0063 16.6 0.0 2.4 2 0 0 2 2 2 1 LCCL domain Macoilin PF09726.9 EGD93636.1 - 5.7 5.4 12.1 8.4 4.8 0.1 2.3 2 0 0 2 2 2 0 Macoilin family Carn_acyltransf PF00755.20 EGD93637.1 - 7.7e-209 695.2 0.0 8.9e-209 694.9 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase DUF2046 PF09755.9 EGD93638.1 - 0.014 14.7 2.2 0.038 13.2 0.3 2.0 2 0 0 2 2 2 0 Uncharacterized conserved protein H4 (DUF2046) TMCO5 PF14992.6 EGD93638.1 - 0.024 14.2 0.2 0.054 13.1 0.2 1.6 1 1 0 1 1 1 0 TMCO5 family Jnk-SapK_ap_N PF09744.9 EGD93638.1 - 0.12 12.6 7.0 0.82 9.9 0.4 2.2 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 Cnn_1N PF07989.11 EGD93638.1 - 0.15 12.3 3.2 0.23 11.6 0.0 2.2 2 0 0 2 2 2 0 Centrosomin N-terminal motif 1 SlyX PF04102.12 EGD93638.1 - 0.15 12.7 8.4 2.8 8.6 2.9 2.5 2 0 0 2 2 2 0 SlyX Uso1_p115_C PF04871.13 EGD93638.1 - 0.64 10.4 6.0 7.3 7.0 1.6 2.4 2 0 0 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region DUF2968 PF11180.8 EGD93638.1 - 0.72 9.5 13.1 0.22 11.2 0.8 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2968) DUF3450 PF11932.8 EGD93638.1 - 2 7.7 10.6 1.1 8.5 0.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) Atg14 PF10186.9 EGD93638.1 - 4 6.4 11.4 0.7 8.9 1.4 2.8 2 1 1 3 3 3 0 Vacuolar sorting 38 and autophagy-related subunit 14 FlxA PF14282.6 EGD93638.1 - 5.4 7.1 18.5 2.9 8.0 1.1 2.6 2 0 0 2 2 2 0 FlxA-like protein GIT_CC PF16559.5 EGD93638.1 - 8.2 6.4 12.0 18 5.3 5.5 2.4 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor Spc24 PF08286.11 EGD93638.1 - 10 6.5 7.6 28 5.0 0.3 2.4 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 Pyr_redox_2 PF07992.14 EGD93639.1 - 3e-05 23.4 0.0 0.00039 19.7 0.0 2.3 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EGD93639.1 - 0.054 13.7 0.0 0.15 12.3 0.0 1.7 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 EGD93639.1 - 0.12 11.0 0.0 0.19 10.4 0.0 1.2 1 0 0 1 1 1 0 HI0933-like protein Lectin_C PF00059.21 EGD93640.1 - 0.00023 21.8 1.3 0.00047 20.9 0.3 2.1 2 0 0 2 2 2 1 Lectin C-type domain Sec62 PF03839.16 EGD93641.1 - 1.5e-73 246.9 0.7 1.5e-73 246.9 0.7 1.9 2 1 1 3 3 3 1 Translocation protein Sec62 Zip PF02535.22 EGD93641.1 - 0.0058 15.9 0.1 0.081 12.1 0.0 2.1 2 0 0 2 2 2 1 ZIP Zinc transporter DUF3439 PF11921.8 EGD93641.1 - 0.6 10.1 10.0 0.32 11.0 2.8 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) ASD2 PF08687.11 EGD93641.1 - 2.7 7.5 7.0 10 5.6 0.1 2.1 2 0 0 2 2 2 0 Apx/Shroom domain ASD2 Ipi1_N PF12333.8 EGD93641.1 - 3.8 8.2 5.7 1.6 9.3 0.0 2.4 2 0 0 2 2 2 0 Rix1 complex component involved in 60S ribosome maturation Tudor_1_RapA PF18339.1 EGD93644.1 - 0.12 12.4 0.0 0.24 11.4 0.0 1.5 1 0 0 1 1 1 0 RapA N-terminal Tudor like domain 1 Usher_TcfC PF17271.2 EGD93644.1 - 0.21 10.3 2.2 0.3 9.8 2.2 1.2 1 0 0 1 1 1 0 TcfC Usher-like barrel domain Cupin_1 PF00190.22 EGD93646.1 - 4.5e-33 114.0 0.0 1.2e-16 60.7 0.0 2.2 2 0 0 2 2 2 2 Cupin Cupin_2 PF07883.11 EGD93646.1 - 1.6e-19 69.4 0.6 1.1e-10 41.1 0.1 2.4 2 0 0 2 2 2 2 Cupin domain Cupin_3 PF05899.12 EGD93646.1 - 3.5e-06 26.6 0.1 0.011 15.4 0.0 2.6 2 0 0 2 2 2 2 Protein of unknown function (DUF861) 3-HAO PF06052.12 EGD93646.1 - 0.18 11.4 0.0 1.4 8.5 0.0 2.3 2 0 0 2 2 2 0 3-hydroxyanthranilic acid dioxygenase Ank_2 PF12796.7 EGD93648.1 - 0.00065 20.2 0.3 0.0065 17.0 0.0 2.7 3 0 0 3 3 3 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EGD93648.1 - 0.0065 17.0 0.0 0.32 11.6 0.0 3.0 2 1 1 3 3 3 2 Ankyrin repeats (many copies) AAA_10 PF12846.7 EGD93648.1 - 0.045 12.7 0.0 0.086 11.7 0.0 1.4 1 0 0 1 1 1 0 AAA-like domain AAA_16 PF13191.6 EGD93648.1 - 0.05 14.0 0.0 0.22 11.9 0.0 2.1 3 0 0 3 3 3 0 AAA ATPase domain ClpB_D2-small PF10431.9 EGD93648.1 - 0.051 13.6 0.0 0.13 12.3 0.0 1.6 1 0 0 1 1 1 0 C-terminal, D2-small domain, of ClpB protein NB-ARC PF00931.22 EGD93648.1 - 0.14 11.3 0.0 0.33 10.1 0.0 1.5 1 0 0 1 1 1 0 NB-ARC domain AAA_7 PF12775.7 EGD93648.1 - 0.2 11.2 0.0 0.74 9.3 0.0 1.9 2 0 0 2 2 2 0 P-loop containing dynein motor region Torus PF16131.5 EGD93648.1 - 0.22 12.3 0.4 0.41 11.4 0.4 1.4 1 0 0 1 1 1 0 Torus domain zf_CCCH_4 PF18345.1 EGD93648.1 - 0.64 10.1 3.3 3.9 7.7 3.3 2.3 1 1 0 1 1 1 0 Zinc finger domain SNAP PF14938.6 EGD93649.1 - 2.6e-109 365.0 15.6 3.1e-109 364.8 15.6 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_12 PF13424.6 EGD93649.1 - 8e-07 29.3 10.5 0.0026 18.0 1.3 4.3 2 1 1 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 EGD93649.1 - 0.00075 19.4 15.1 0.7 10.1 0.1 6.7 4 1 1 6 6 6 1 Tetratricopeptide repeat TPR_7 PF13176.6 EGD93649.1 - 0.0022 17.9 3.9 22 5.4 0.0 5.7 3 1 2 5 5 5 0 Tetratricopeptide repeat TPR_16 PF13432.6 EGD93649.1 - 0.035 14.8 12.8 2.7 8.7 3.2 4.6 1 1 3 4 4 4 0 Tetratricopeptide repeat NSF PF02071.20 EGD93649.1 - 0.17 12.7 0.4 0.17 12.7 0.4 6.1 6 0 0 6 6 6 0 Aromatic-di-Alanine (AdAR) repeat TPR_8 PF13181.6 EGD93649.1 - 0.54 10.6 0.1 0.54 10.6 0.1 6.2 7 0 0 7 7 7 0 Tetratricopeptide repeat MIT PF04212.18 EGD93649.1 - 0.59 10.2 8.3 19 5.4 0.1 4.8 3 1 2 5 5 5 0 MIT (microtubule interacting and transport) domain TPR_6 PF13174.6 EGD93649.1 - 0.99 10.2 16.8 5 8.0 0.1 5.5 8 0 0 8 8 8 0 Tetratricopeptide repeat DUF726 PF05277.12 EGD93650.1 - 1.6e-121 405.4 0.4 2.6e-121 404.8 0.4 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF726) Glu-tRNAGln PF02686.15 EGD93650.1 - 1.5e-12 47.6 0.3 9.3e-12 45.1 0.1 2.5 2 1 0 2 2 2 1 Glu-tRNAGln amidotransferase C subunit DUF4407 PF14362.6 EGD93650.1 - 0.069 12.5 1.3 0.25 10.7 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Thioesterase PF00975.20 EGD93650.1 - 0.08 13.0 0.1 0.26 11.4 0.0 1.8 2 0 0 2 2 2 0 Thioesterase domain HlyIII PF03006.20 EGD93651.1 - 5.1e-37 127.7 12.3 7.1e-37 127.3 12.3 1.1 1 0 0 1 1 1 1 Haemolysin-III related ATP-synt_8 PF00895.20 EGD93651.1 - 0.27 11.7 0.3 0.27 11.7 0.3 2.3 2 0 0 2 2 2 0 ATP synthase protein 8 RIBIOP_C PF04950.12 EGD93652.1 - 9.5e-110 366.6 0.0 2.8e-109 365.0 0.0 1.8 2 0 0 2 2 2 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal AARP2CN PF08142.12 EGD93652.1 - 1.6e-23 82.6 0.0 3.7e-23 81.4 0.0 1.7 1 0 0 1 1 1 1 AARP2CN (NUC121) domain BING4CT PF08149.11 EGD93653.1 - 2.5e-39 132.9 0.2 1.6e-35 120.8 0.0 3.4 3 1 1 4 4 4 2 BING4CT (NUC141) domain ANAPC4_WD40 PF12894.7 EGD93653.1 - 4.8e-07 30.0 0.4 5.8 7.3 0.0 5.2 3 2 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EGD93653.1 - 0.0006 20.6 2.3 0.41 11.6 0.0 4.4 4 1 1 5 5 5 1 WD domain, G-beta repeat DUF4427 PF14468.6 EGD93653.1 - 0.033 14.3 0.3 0.11 12.5 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF4427) Nucleoporin_N PF08801.11 EGD93653.1 - 0.1 11.3 0.0 0.15 10.8 0.0 1.2 1 0 0 1 1 1 0 Nup133 N terminal like CHASE3 PF05227.13 EGD93653.1 - 4.1 7.3 11.0 0.16 11.9 4.3 2.0 2 1 0 2 2 2 0 CHASE3 domain cobW PF02492.19 EGD93654.1 - 2.5e-33 115.1 0.0 3.1e-33 114.9 0.0 1.1 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain MeaB PF03308.16 EGD93654.1 - 4.7e-06 25.8 0.0 0.0065 15.5 0.0 2.0 2 0 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_23 PF13476.6 EGD93654.1 - 0.0054 17.3 0.0 0.0077 16.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.23 EGD93654.1 - 0.0062 16.6 0.0 0.014 15.4 0.0 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase NACHT PF05729.12 EGD93654.1 - 0.036 14.0 0.0 0.057 13.3 0.0 1.3 1 0 0 1 1 1 0 NACHT domain CbiA PF01656.23 EGD93654.1 - 0.075 13.1 0.0 0.15 12.1 0.0 1.4 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain IstB_IS21 PF01695.17 EGD93654.1 - 0.13 11.9 0.0 0.27 11.0 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein GTP_EFTU PF00009.27 EGD93654.1 - 0.14 11.6 0.1 6.1 6.3 0.0 2.5 2 1 0 2 2 2 0 Elongation factor Tu GTP binding domain AAA_5 PF07728.14 EGD93654.1 - 0.16 12.0 0.0 0.22 11.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) ResIII PF04851.15 EGD93654.1 - 0.18 11.8 0.0 0.24 11.4 0.0 1.4 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit PRK PF00485.18 EGD93654.1 - 0.2 11.4 0.0 0.66 9.7 0.0 1.8 1 1 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family LIM_bind PF01803.16 EGD93655.1 - 1.8e-45 155.4 0.0 1.8e-45 155.4 0.0 4.0 2 1 1 3 3 3 1 LIM-domain binding protein AAA PF00004.29 EGD93656.1 - 9.1e-39 132.9 0.0 1.1e-37 129.4 0.0 2.3 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EGD93656.1 - 3.1e-09 36.5 0.0 8.8e-09 35.0 0.0 1.9 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 EGD93656.1 - 8.1e-05 23.1 0.5 0.001 19.5 0.0 3.1 2 1 0 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 EGD93656.1 - 0.00014 21.6 0.0 0.00032 20.5 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EGD93656.1 - 0.00023 21.5 0.1 0.018 15.3 0.0 2.7 1 1 1 2 2 2 1 AAA domain TIP49 PF06068.13 EGD93656.1 - 0.00041 19.7 0.0 0.00084 18.6 0.0 1.5 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_5 PF07728.14 EGD93656.1 - 0.0007 19.6 0.0 0.0031 17.5 0.0 2.1 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 EGD93656.1 - 0.0011 19.2 0.0 0.0037 17.4 0.0 2.0 2 0 0 2 2 2 1 AAA domain Mg_chelatase PF01078.21 EGD93656.1 - 0.0042 16.5 0.1 0.01 15.3 0.1 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 EGD93656.1 - 0.012 15.3 0.0 0.024 14.4 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_14 PF13173.6 EGD93656.1 - 0.014 15.5 0.0 0.034 14.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 EGD93656.1 - 0.021 15.4 0.0 0.094 13.3 0.0 2.2 2 0 0 2 2 1 0 AAA domain RNA_helicase PF00910.22 EGD93656.1 - 0.026 14.9 0.0 0.065 13.6 0.0 1.7 1 0 0 1 1 1 0 RNA helicase AAA_28 PF13521.6 EGD93656.1 - 0.026 14.7 0.0 0.082 13.2 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 EGD93656.1 - 0.027 14.2 0.1 0.072 12.8 0.0 1.7 2 0 0 2 2 1 0 AAA domain TniB PF05621.11 EGD93656.1 - 0.067 12.6 0.0 0.31 10.4 0.0 2.0 3 0 0 3 3 3 0 Bacterial TniB protein AAA_17 PF13207.6 EGD93656.1 - 0.074 13.5 0.1 0.25 11.8 0.1 2.0 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 EGD93656.1 - 0.087 12.8 0.1 0.24 11.4 0.0 1.7 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_2 PF07724.14 EGD93656.1 - 0.13 12.4 0.0 0.96 9.5 0.0 2.4 2 1 0 2 2 1 0 AAA domain (Cdc48 subfamily) NACHT PF05729.12 EGD93656.1 - 0.15 12.0 0.2 0.43 10.5 0.1 1.8 2 0 0 2 2 2 0 NACHT domain IPT PF01745.16 EGD93656.1 - 0.15 11.4 0.0 0.31 10.4 0.0 1.4 1 0 0 1 1 1 0 Isopentenyl transferase Sigma54_activat PF00158.26 EGD93656.1 - 0.17 11.6 0.2 2.3 7.9 0.0 2.3 2 0 0 2 2 2 0 Sigma-54 interaction domain Pkinase PF00069.25 EGD93657.1 - 4.4e-17 62.3 0.0 6.5e-17 61.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD93657.1 - 7.6e-09 35.2 0.0 4.2e-08 32.8 0.0 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase RIO1 PF01163.22 EGD93657.1 - 0.034 13.7 0.0 0.075 12.6 0.0 1.5 1 0 0 1 1 1 0 RIO1 family DUF600 PF04634.12 EGD93657.1 - 0.037 14.1 0.3 0.23 11.5 0.1 2.1 2 1 0 2 2 2 0 Protein of unknown function, DUF600 APH PF01636.23 EGD93657.1 - 0.038 13.9 0.1 0.066 13.1 0.1 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.11 EGD93657.1 - 0.11 11.5 0.0 0.15 11.0 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Pkinase_fungal PF17667.1 EGD93657.1 - 0.12 11.1 0.1 0.23 10.2 0.0 1.4 2 0 0 2 2 2 0 Fungal protein kinase TPR_19 PF14559.6 EGD93658.1 - 0.0004 20.8 2.4 0.47 11.0 2.1 3.7 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_12 PF13424.6 EGD93658.1 - 0.00095 19.4 3.6 0.94 9.8 0.3 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 EGD93658.1 - 0.042 14.0 2.5 20 5.6 0.0 4.7 5 0 0 5 5 5 0 Tetratricopeptide repeat DUF4050 PF13259.6 EGD93660.1 - 2e-56 191.2 1.0 2e-56 191.2 1.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF4050) Mus7 PF09462.10 EGD93661.1 - 2.6e-160 535.3 0.0 3.6e-160 534.8 0.0 1.2 1 0 0 1 1 1 1 Mus7/MMS22 family PAPA-1 PF04795.12 EGD93663.1 - 8e-32 109.9 5.6 8e-32 109.9 5.6 3.1 3 0 0 3 3 3 1 PAPA-1-like conserved region Pex14_N PF04695.13 EGD93664.1 - 2.2e-43 148.6 3.2 2.2e-43 148.6 3.2 2.4 2 0 0 2 2 2 1 Peroxisomal membrane anchor protein (Pex14p) conserved region Sigma70_ECF PF07638.11 EGD93664.1 - 0.09 12.7 0.2 0.18 11.7 0.2 1.4 1 0 0 1 1 1 0 ECF sigma factor Calcipressin PF04847.12 EGD93665.1 - 1e-33 116.7 0.1 1.5e-33 116.1 0.1 1.2 1 0 0 1 1 1 1 Calcipressin YhdX PF17444.2 EGD93665.1 - 0.11 12.3 0.1 0.28 11.0 0.0 1.7 2 0 0 2 2 2 0 Uncharacterized YhdX-like DUF3394 PF11874.8 EGD93667.1 - 0.15 11.8 0.0 0.15 11.7 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3394) Uds1 PF15456.6 EGD93669.1 - 1.3e-28 99.7 3.7 2.9e-28 98.7 3.7 1.6 1 0 0 1 1 1 1 Up-regulated During Septation Stathmin PF00836.19 EGD93669.1 - 0.014 15.4 1.3 0.036 14.0 0.3 2.2 2 0 0 2 2 2 0 Stathmin family GrpE PF01025.19 EGD93670.1 - 8.6e-43 145.9 2.3 1.3e-42 145.3 2.3 1.2 1 0 0 1 1 1 1 GrpE DLEU7 PF15760.5 EGD93670.1 - 0.044 13.3 0.8 0.071 12.6 0.7 1.4 1 1 0 1 1 1 0 Leukemia-associated protein 7 PEARLI-4 PF05278.12 EGD93670.1 - 0.076 12.6 2.5 0.12 12.0 2.5 1.3 1 0 0 1 1 1 0 Arabidopsis phospholipase-like protein (PEARLI 4) HSCB_C PF07743.13 EGD93670.1 - 3.8 8.1 8.4 2.2 8.9 2.8 2.3 1 1 1 2 2 2 0 HSCB C-terminal oligomerisation domain tRNA-synt_2d PF01409.20 EGD93671.1 - 9.2e-48 162.8 0.0 1.6e-26 93.3 0.0 2.2 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) FDX-ACB PF03147.14 EGD93671.1 - 0.00014 22.2 0.0 0.00039 20.8 0.0 1.7 1 0 0 1 1 1 1 Ferredoxin-fold anticodon binding domain Mito_carr PF00153.27 EGD93672.1 - 2.4e-49 165.2 0.1 1.1e-17 63.7 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein COX6B PF02297.17 EGD93673.1 - 1.9e-19 69.7 7.1 2.2e-19 69.4 7.1 1.1 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb ketoacyl-synt PF00109.26 EGD93673.1 - 0.034 13.7 0.0 0.034 13.7 0.0 1.1 1 0 0 1 1 1 0 Beta-ketoacyl synthase, N-terminal domain T2SSJ PF11612.8 EGD93673.1 - 0.041 14.1 0.5 0.77 10.0 0.5 2.0 1 1 0 1 1 1 0 Type II secretion system (T2SS), protein J CHCH PF06747.13 EGD93673.1 - 0.042 14.0 1.2 0.11 12.7 1.3 1.7 1 1 0 1 1 1 0 CHCH domain CX9C PF16860.5 EGD93673.1 - 0.05 13.6 4.1 0.058 13.4 3.1 1.6 1 1 1 2 2 2 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, APOBEC_C PF05240.14 EGD93673.1 - 0.065 13.2 2.6 0.076 13.0 2.0 1.5 1 1 0 1 1 1 0 APOBEC-like C-terminal domain RRM_1 PF00076.22 EGD93675.1 - 7.3e-16 57.7 0.0 1e-15 57.3 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EGD93675.1 - 0.11 12.6 0.0 0.17 12.0 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif Nup35_RRM_2 PF14605.6 EGD93675.1 - 0.12 12.4 0.0 0.22 11.5 0.0 1.5 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif SRA1 PF07304.11 EGD93676.1 - 2.5e-12 46.8 0.0 2.5e-12 46.8 0.0 2.5 2 0 0 2 2 2 1 Steroid receptor RNA activator (SRA1) Sec16_C PF12931.7 EGD93676.1 - 1.2e-07 31.7 0.1 2.3e-06 27.5 0.1 2.2 1 1 0 1 1 1 1 Sec23-binding domain of Sec16 WD40 PF00400.32 EGD93676.1 - 4e-07 30.6 3.3 0.22 12.5 0.0 5.9 7 0 0 7 7 7 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EGD93676.1 - 0.00033 20.9 0.1 0.043 14.1 0.1 3.6 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Prp18 PF02840.15 EGD93676.1 - 0.0026 17.8 0.2 0.013 15.6 0.0 2.1 2 0 0 2 2 2 1 Prp18 domain Transp_cyt_pur PF02133.15 EGD93677.1 - 2.6e-23 82.5 27.7 1.9e-13 50.0 2.0 2.1 1 1 0 2 2 2 2 Permease for cytosine/purines, uracil, thiamine, allantoin DUF1418 PF07214.12 EGD93677.1 - 0.13 12.1 4.2 2.7 7.9 2.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1418) ATE_C PF04377.15 EGD93678.1 - 1.1e-34 119.9 1.0 2.1e-34 119.0 1.0 1.4 1 0 0 1 1 1 1 Arginine-tRNA-protein transferase, C terminus ATE_N PF04376.13 EGD93678.1 - 1.5e-23 83.0 3.7 3.6e-23 81.8 3.7 1.7 1 0 0 1 1 1 1 Arginine-tRNA-protein transferase, N terminus Acetyltransf_6 PF13480.7 EGD93678.1 - 0.11 12.7 0.1 0.11 12.7 0.1 2.0 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain NUDIX PF00293.28 EGD93679.1 - 1.4e-18 67.2 0.2 1.7e-18 66.9 0.2 1.1 1 0 0 1 1 1 1 NUDIX domain RNA_pol_A_bac PF01000.26 EGD93680.1 - 1.7e-30 105.6 0.0 2.7e-30 105.0 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 EGD93680.1 - 2.1e-14 52.7 0.0 2.7e-14 52.3 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Baculo_PEP_C PF04513.12 EGD93681.1 - 0.1 12.6 5.7 0.55 10.3 0.2 2.5 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Cytochrom_C PF00034.21 EGD93684.1 - 3.4e-11 44.1 0.0 1.1e-10 42.5 0.0 1.8 2 0 0 2 2 2 1 Cytochrome c Cytochrome_CBB3 PF13442.6 EGD93684.1 - 2.5e-08 34.1 0.9 2e-07 31.2 0.9 2.2 1 1 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III CCP_MauG PF03150.14 EGD93684.1 - 0.02 15.5 0.0 0.032 14.9 0.0 1.4 1 0 0 1 1 1 0 Di-haem cytochrome c peroxidase BPS1 PF05633.11 EGD93684.1 - 0.037 13.0 0.0 0.049 12.6 0.0 1.1 1 0 0 1 1 1 0 Protein BYPASS1-related Cytochrom_C550 PF14495.6 EGD93684.1 - 0.087 12.5 0.1 0.45 10.2 0.0 2.0 2 0 0 2 2 2 0 Cytochrome c-550 domain Ferritin-like PF12902.7 EGD93685.1 - 0.065 13.1 0.0 0.1 12.4 0.0 1.2 1 0 0 1 1 1 0 Ferritin-like DUF390 PF04094.14 EGD93685.1 - 0.077 11.3 0.6 0.094 11.0 0.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF390) RNase_PH PF01138.21 EGD93686.1 - 6.2e-12 46.1 0.0 1.7e-11 44.7 0.0 1.8 1 1 0 1 1 1 1 3' exoribonuclease family, domain 1 CW_binding_2 PF04122.12 EGD93687.1 - 0.19 12.4 0.2 0.8 10.4 0.1 1.9 2 0 0 2 2 2 0 Putative cell wall binding repeat 2 Metallophos PF00149.28 EGD93688.1 - 8.4e-12 46.0 0.3 1e-11 45.7 0.3 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Inv-AAD PF18785.1 EGD93689.1 - 8.9e-47 158.2 0.1 1.5e-46 157.4 0.1 1.3 1 0 0 1 1 1 1 Invertebrate-AID/APOBEC-deaminase dCMP_cyt_deam_1 PF00383.23 EGD93689.1 - 4e-09 36.3 0.1 4.6e-08 32.9 0.0 2.4 2 1 0 2 2 2 1 Cytidine and deoxycytidylate deaminase zinc-binding region APOBEC_N PF08210.11 EGD93689.1 - 2.2e-06 27.7 0.0 3e-06 27.2 0.0 1.3 1 1 0 1 1 1 1 APOBEC-like N-terminal domain NAD1 PF18778.1 EGD93689.1 - 0.051 13.7 0.0 0.1 12.7 0.0 1.6 1 1 0 1 1 1 0 Novel AID APOBEC clade 1 SNAD4 PF18750.1 EGD93689.1 - 0.061 13.4 0.0 0.15 12.2 0.0 1.7 1 1 0 1 1 1 0 Secreted Novel AID/APOBEC-like Deaminase 4 Stn1 PF10451.9 EGD93694.1 - 4.2e-13 48.9 0.2 7.2e-12 44.8 0.2 2.0 1 1 0 1 1 1 1 Telomere regulation protein Stn1 Vma12 PF11712.8 EGD93694.1 - 0.53 10.3 3.5 0.94 9.5 3.5 1.3 1 0 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase SelP_N PF04592.14 EGD93695.1 - 3.3 7.0 12.6 6.1 6.2 12.6 1.3 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Abhydrolase_1 PF00561.20 EGD93696.1 - 1.2e-12 48.1 0.1 2.5e-11 43.7 0.1 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EGD93696.1 - 0.0092 15.3 0.0 0.073 12.3 0.0 2.0 1 1 0 1 1 1 1 Serine aminopeptidase, S33 F-box-like PF12937.7 EGD93697.1 - 0.00034 20.4 0.1 0.0011 18.8 0.1 1.9 1 0 0 1 1 1 1 F-box-like APH PF01636.23 EGD93699.1 - 3.8e-12 46.6 0.0 4.2e-11 43.2 0.0 2.3 1 1 0 1 1 1 1 Phosphotransferase enzyme family DUF1679 PF07914.11 EGD93699.1 - 0.11 11.4 0.1 1.4 7.7 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1679) Stc1 PF12898.7 EGD93700.1 - 4.7e-20 71.9 11.1 9.6e-20 70.9 11.1 1.5 1 0 0 1 1 1 1 Stc1 domain His_Me_b4a2 PF18275.1 EGD93700.1 - 2.3 8.4 13.9 2.8 8.1 2.1 3.3 3 1 0 3 3 3 0 His-Me finger endonuclease beta4-alpha2 domain F-box-like PF12937.7 EGD93702.1 - 0.0035 17.2 0.0 0.0061 16.4 0.0 1.3 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EGD93702.1 - 0.0083 16.0 1.2 0.025 14.5 0.2 2.2 2 1 0 2 2 2 1 F-box domain Sporozoite_P67 PF05642.11 EGD93705.1 - 0.052 11.6 2.1 0.052 11.6 2.1 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Calc_CGRP_IAPP PF00214.19 EGD93705.1 - 0.073 13.4 0.2 0.086 13.2 0.2 1.1 1 0 0 1 1 1 0 Calcitonin / CGRP / IAPP family FAM176 PF14851.6 EGD93705.1 - 0.077 12.6 1.9 0.087 12.5 1.9 1.2 1 0 0 1 1 1 0 FAM176 family U79_P34 PF03064.16 EGD93705.1 - 0.3 10.4 4.7 0.34 10.2 4.7 1.1 1 0 0 1 1 1 0 HSV U79 / HCMV P34 NARP1 PF12569.8 EGD93705.1 - 1.4 7.7 7.4 1.6 7.5 7.4 1.0 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Paf1 PF03985.13 EGD93705.1 - 1.6 7.7 8.8 1.7 7.5 8.8 1.0 1 0 0 1 1 1 0 Paf1 CDC45 PF02724.14 EGD93705.1 - 3 6.0 6.3 3.1 6.0 6.3 1.0 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 EGD93705.1 - 3.3 6.4 3.5 3.4 6.3 3.5 1.0 1 0 0 1 1 1 0 Presenilin Pkinase PF00069.25 EGD93706.1 - 1.2e-57 195.3 0.0 2.4e-57 194.3 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD93706.1 - 1.1e-32 113.3 0.0 9.4e-32 110.3 0.0 2.1 2 0 0 2 2 2 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EGD93706.1 - 0.0006 18.9 0.2 0.0013 17.8 0.0 1.6 2 0 0 2 2 2 1 Haspin like kinase domain Pox_ser-thr_kin PF05445.11 EGD93706.1 - 0.078 11.9 0.0 0.11 11.5 0.0 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase MbeB_N PF04837.12 EGD93707.1 - 0.078 13.3 0.4 5.2 7.4 0.0 2.5 2 0 0 2 2 2 0 MbeB-like, N-term conserved region BEN PF10523.9 EGD93708.1 - 0.12 12.7 0.1 13 6.1 0.0 3.0 2 1 1 3 3 3 0 BEN domain DnaJ PF00226.31 EGD93709.1 - 6.3e-22 77.5 1.5 6.3e-22 77.5 1.5 1.9 2 0 0 2 2 2 1 DnaJ domain MetOD1 PF18546.1 EGD93709.1 - 0.52 10.3 1.5 0.5 10.3 0.1 1.6 2 0 0 2 2 2 0 Metanogen output domain 1 TMIE PF16038.5 EGD93710.1 - 0.16 11.8 0.3 2.8 7.9 0.0 2.1 2 0 0 2 2 2 0 TMIE protein Usp PF00582.26 EGD93711.1 - 7.7e-22 78.3 0.9 1.7e-14 54.5 0.3 2.7 2 0 0 2 2 2 2 Universal stress protein family DUF3716 PF12511.8 EGD93712.1 - 1.5e-09 37.7 1.1 2.3e-09 37.1 1.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3716) Peptidase_S10 PF00450.22 EGD93715.1 - 8.2e-72 242.9 0.0 1.6e-71 241.9 0.0 1.4 1 1 0 1 1 1 1 Serine carboxypeptidase GCK PF07802.11 EGD93715.1 - 0.021 15.2 0.1 0.047 14.1 0.1 1.5 1 0 0 1 1 1 0 GCK domain ATP-synt_ab PF00006.25 EGD93716.1 - 1.7e-67 227.2 0.0 2.3e-67 226.8 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 EGD93716.1 - 3.4e-12 46.7 0.8 7e-12 45.7 0.8 1.6 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain Adeno_E3_CR2 PF02439.15 EGD93717.1 - 0.04 13.7 0.0 0.07 12.9 0.0 1.4 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 DUF5305 PF17231.2 EGD93717.1 - 0.077 12.4 0.2 0.42 10.0 0.0 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5305) Gram_pos_anchor PF00746.21 EGD93717.1 - 1.2 9.1 3.4 0.32 11.0 0.4 1.7 2 0 0 2 2 2 0 LPXTG cell wall anchor motif Trp_syntA PF00290.20 EGD93718.1 - 6.8e-94 313.5 0.0 1.3e-93 312.6 0.0 1.4 1 0 0 1 1 1 1 Tryptophan synthase alpha chain PALP PF00291.25 EGD93718.1 - 6.7e-48 163.6 2.2 1.1e-47 162.9 2.2 1.3 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme TIG PF01833.24 EGD93719.1 - 0.014 15.4 2.1 0.019 15.0 0.4 2.2 2 0 0 2 2 2 0 IPT/TIG domain ADH_zinc_N PF00107.26 EGD93722.1 - 2.7e-23 82.4 1.0 4e-23 81.8 1.0 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EGD93722.1 - 8.7e-09 36.5 0.0 2e-08 35.3 0.0 1.7 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EGD93722.1 - 0.0002 21.2 0.0 0.00039 20.3 0.0 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain AlaDh_PNT_C PF01262.21 EGD93722.1 - 0.024 13.9 1.6 0.042 13.1 1.6 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain adh_short PF00106.25 EGD93722.1 - 0.039 13.4 1.4 0.1 12.1 0.6 2.1 2 1 0 2 2 2 0 short chain dehydrogenase APH PF01636.23 EGD93723.1 - 1.6e-13 51.1 0.0 4.5e-13 49.7 0.0 1.8 1 1 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 EGD93723.1 - 0.0018 17.7 0.0 0.58 9.5 0.0 2.9 3 0 0 3 3 3 2 Lipopolysaccharide kinase (Kdo/WaaP) family DUF1679 PF07914.11 EGD93723.1 - 0.0032 16.4 0.0 0.38 9.6 0.0 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF1679) Choline_kinase PF01633.20 EGD93723.1 - 0.079 12.5 0.0 0.15 11.7 0.0 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase RIO1 PF01163.22 EGD93723.1 - 0.14 11.8 0.0 9 5.8 0.0 2.3 2 0 0 2 2 2 0 RIO1 family DUF4407 PF14362.6 EGD93724.1 - 0.047 13.0 0.1 0.079 12.3 0.1 1.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) HNH_2 PF13391.6 EGD93725.1 - 1.7e-11 44.1 0.0 3.7e-11 43.0 0.0 1.6 1 0 0 1 1 1 1 HNH endonuclease GYF PF02213.16 EGD93728.1 - 1.6e-16 59.7 1.9 4e-16 58.4 0.4 2.5 2 0 0 2 2 2 1 GYF domain B12D PF06522.11 EGD93728.1 - 0.043 13.6 0.7 0.14 12.0 0.0 2.2 2 0 0 2 2 2 0 NADH-ubiquinone reductase complex 1 MLRQ subunit GYF_2 PF14237.6 EGD93728.1 - 0.15 11.9 0.3 0.44 10.4 0.3 1.9 1 0 0 1 1 1 0 GYF domain 2 Homeodomain PF00046.29 EGD93728.1 - 0.45 10.4 3.7 1.4 8.8 3.7 1.8 1 0 0 1 1 1 0 Homeodomain Aminotran_5 PF00266.19 EGD93729.1 - 6.1e-19 68.2 0.0 9.7e-19 67.6 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.21 EGD93729.1 - 0.00064 19.0 0.0 0.00092 18.5 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 EGD93729.1 - 0.0014 17.3 0.0 0.0021 16.6 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme zf-RING_2 PF13639.6 EGD93730.1 - 2.2e-13 50.3 9.4 2.2e-13 50.3 9.4 2.3 2 0 0 2 2 2 1 Ring finger domain zf-RING_11 PF17123.5 EGD93730.1 - 3.4e-11 42.7 8.8 1.1e-10 41.1 4.4 2.4 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 EGD93730.1 - 2.5e-09 36.8 8.6 2.5e-09 36.8 8.6 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EGD93730.1 - 3e-09 36.6 11.6 6.6e-08 32.3 4.5 2.2 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EGD93730.1 - 3.4e-07 30.4 8.2 3.4e-07 30.4 8.2 2.4 2 0 0 2 2 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 EGD93730.1 - 4.5e-07 29.6 18.1 7.6e-07 28.9 8.7 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EGD93730.1 - 4.6e-07 29.7 6.1 4.6e-07 29.7 6.1 2.4 2 0 0 2 2 2 1 zinc-RING finger domain zinc_ribbon_9 PF14369.6 EGD93730.1 - 2e-06 27.9 10.4 0.00015 22.0 5.1 2.5 2 0 0 2 2 2 2 zinc-ribbon Prok-RING_4 PF14447.6 EGD93730.1 - 5.8e-06 26.1 14.6 0.00015 21.6 5.2 2.3 2 0 0 2 2 2 2 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 EGD93730.1 - 4.3e-05 23.5 3.3 4.3e-05 23.5 3.3 2.7 2 0 0 2 2 2 1 RING-type zinc-finger zf-ANAPC11 PF12861.7 EGD93730.1 - 0.00035 20.6 2.2 0.00035 20.6 2.2 2.1 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger HypA PF01155.19 EGD93730.1 - 0.00074 19.5 7.1 0.0014 18.7 0.4 2.3 2 0 0 2 2 2 1 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Zn_ribbon_17 PF17120.5 EGD93730.1 - 0.0042 16.7 6.6 0.0042 16.7 6.6 2.3 2 0 0 2 2 2 1 Zinc-ribbon, C4HC2 type DZR PF12773.7 EGD93730.1 - 0.04 14.0 8.3 0.068 13.2 0.2 2.7 2 1 0 2 2 2 0 Double zinc ribbon zf-C3HC4_4 PF15227.6 EGD93730.1 - 0.061 13.5 13.4 1.7 8.8 0.7 2.5 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING Baculo_RING PF05883.11 EGD93730.1 - 0.1 12.6 2.6 0.29 11.1 0.5 2.2 2 0 0 2 2 2 0 Baculovirus U-box/Ring-like domain zf-RING_4 PF14570.6 EGD93730.1 - 0.12 12.1 14.1 0.18 11.6 4.7 2.3 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain Spt20 PF12090.8 EGD93730.1 - 0.57 9.7 13.3 0.036 13.7 7.7 1.7 2 0 0 2 2 2 0 Spt20 family DUF1272 PF06906.11 EGD93730.1 - 0.68 10.1 9.8 2.1 8.5 3.3 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1272) PHD PF00628.29 EGD93730.1 - 0.86 9.6 14.3 0.74 9.8 7.1 2.6 2 0 0 2 2 2 0 PHD-finger UPF0547 PF10571.9 EGD93730.1 - 2.5 8.2 9.7 4.4 7.5 0.2 3.4 3 0 0 3 3 3 0 Uncharacterised protein family UPF0547 zinc-ribbons_6 PF07191.12 EGD93730.1 - 2.9 8.0 13.7 0.4 10.7 0.9 2.7 2 1 0 2 2 2 0 zinc-ribbons Fis1_TPR_C PF14853.6 EGD93731.1 - 5.5e-26 90.4 0.4 8.8e-26 89.7 0.4 1.3 1 0 0 1 1 1 1 Fis1 C-terminal tetratricopeptide repeat Fis1_TPR_N PF14852.6 EGD93731.1 - 6.6e-17 60.9 0.0 1e-16 60.3 0.0 1.3 1 0 0 1 1 1 1 Fis1 N-terminal tetratricopeptide repeat TPR_2 PF07719.17 EGD93731.1 - 0.00099 19.1 1.6 0.0023 17.9 1.6 1.7 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_1 PF00515.28 EGD93731.1 - 2.5 8.1 6.7 0.23 11.4 2.4 1.5 2 0 0 2 2 2 0 Tetratricopeptide repeat Spc24 PF08286.11 EGD93732.1 - 2.5e-39 133.7 3.1 9.2e-38 128.7 0.2 2.2 2 0 0 2 2 2 1 Spc24 subunit of Ndc80 APG6_N PF17675.1 EGD93732.1 - 0.0032 18.0 11.4 0.0044 17.5 11.4 1.2 1 0 0 1 1 1 1 Apg6 coiled-coil region MAP65_ASE1 PF03999.12 EGD93732.1 - 0.0037 16.1 3.4 0.0039 16.0 3.4 1.1 1 0 0 1 1 1 1 Microtubule associated protein (MAP65/ASE1 family) FlaC_arch PF05377.11 EGD93732.1 - 0.017 15.5 2.9 0.79 10.2 0.2 2.5 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) WXG100 PF06013.12 EGD93732.1 - 0.02 15.1 3.0 0.18 12.0 0.2 2.6 2 1 0 2 2 2 0 Proteins of 100 residues with WXG Syntaxin PF00804.25 EGD93732.1 - 0.023 14.4 3.0 0.045 13.4 3.0 1.5 1 0 0 1 1 1 0 Syntaxin Spc7 PF08317.11 EGD93732.1 - 0.03 13.2 8.1 0.04 12.8 8.1 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein FlxA PF14282.6 EGD93732.1 - 0.03 14.3 2.4 2.2 8.3 0.1 2.2 2 0 0 2 2 2 0 FlxA-like protein CLZ PF16526.5 EGD93732.1 - 0.072 13.5 9.1 0.2 12.0 1.5 2.4 2 0 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels DUF4472 PF14739.6 EGD93732.1 - 0.072 13.8 1.7 0.072 13.8 1.7 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4472) DUF4795 PF16043.5 EGD93732.1 - 0.092 12.3 4.8 0.5 9.9 4.6 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4795) DUF4337 PF14235.6 EGD93732.1 - 0.1 12.7 3.9 0.13 12.3 2.8 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4337) Prefoldin_2 PF01920.20 EGD93732.1 - 0.1 12.5 6.3 0.66 10.0 1.0 2.3 2 0 0 2 2 2 0 Prefoldin subunit DUF5344 PF17279.2 EGD93732.1 - 0.12 13.0 2.4 4.2 8.0 0.1 2.6 3 0 0 3 3 2 0 Family of unknown function (DUF5344) Streptin-Immun PF11083.8 EGD93732.1 - 0.12 12.7 1.1 0.42 11.1 0.1 2.0 1 1 1 2 2 2 0 Lantibiotic streptin immunity protein V_ATPase_I PF01496.19 EGD93732.1 - 0.14 10.0 1.3 0.14 10.0 1.3 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family FapA PF03961.13 EGD93732.1 - 0.18 10.4 1.8 0.21 10.2 1.8 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A DHR10 PF18595.1 EGD93732.1 - 0.27 11.3 14.2 1.1 9.3 14.2 1.9 1 1 0 1 1 1 0 Designed helical repeat protein 10 domain EAP30 PF04157.16 EGD93732.1 - 0.28 10.4 5.6 19 4.5 5.6 2.1 1 1 0 1 1 1 0 EAP30/Vps36 family YlqD PF11068.8 EGD93732.1 - 0.49 10.8 4.4 0.76 10.1 4.4 1.3 1 0 0 1 1 1 0 YlqD protein Phage_GPO PF05929.11 EGD93732.1 - 0.53 9.9 5.9 2.5 7.7 5.8 1.9 1 1 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase Swi5 PF07061.11 EGD93732.1 - 0.62 10.2 3.9 9.4 6.4 0.4 2.4 2 0 0 2 2 2 0 Swi5 Ribosomal_L29 PF00831.23 EGD93732.1 - 0.67 10.0 6.9 2.2 8.3 0.5 2.6 2 0 0 2 2 2 0 Ribosomal L29 protein SlyX PF04102.12 EGD93732.1 - 1 10.1 7.8 1.8 9.2 1.1 2.5 2 1 0 2 2 2 0 SlyX Csm1_N PF18504.1 EGD93732.1 - 1.1 9.7 6.8 6.8 7.1 0.9 2.3 2 0 0 2 2 2 0 Csm1 N-terminal domain YabA PF06156.13 EGD93732.1 - 1.2 9.8 4.4 22 5.7 0.3 2.2 1 1 1 2 2 2 0 Initiation control protein YabA DUF2937 PF11157.8 EGD93732.1 - 1.3 8.7 3.8 1.2 8.9 0.5 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2937) Viral_P18 PF04521.13 EGD93732.1 - 2.4 8.0 6.4 6.4 6.6 1.0 2.4 1 1 1 2 2 2 0 ssRNA positive strand viral 18kD cysteine rich protein DUF1690 PF07956.11 EGD93732.1 - 4.9 7.6 9.7 14 6.0 9.7 1.7 1 1 0 1 1 1 0 Protein of Unknown function (DUF1690) DUF4140 PF13600.6 EGD93732.1 - 5 7.6 9.2 12 6.4 2.9 2.6 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) DASH_Hsk3 PF08227.11 EGD93732.1 - 5.4 7.5 9.4 3 8.3 0.8 2.7 2 1 1 3 3 3 0 DASH complex subunit Hsk3 like DUF3431 PF11913.8 EGD93733.1 - 5.1e-83 278.1 0.0 6.5e-83 277.7 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3431) MbtH PF03621.13 EGD93733.1 - 0.13 11.8 0.1 0.3 10.5 0.1 1.6 1 0 0 1 1 1 0 MbtH-like protein DUF2034 PF10356.9 EGD93734.1 - 1.9e-37 128.5 0.0 4e-21 75.3 0.0 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF2034) Mrr_cat PF04471.12 EGD93734.1 - 1.5e-08 34.7 0.0 2.3e-08 34.0 0.0 1.2 1 0 0 1 1 1 1 Restriction endonuclease Med21 PF11221.8 EGD93735.1 - 4e-54 182.8 18.1 1.2e-52 178.0 18.1 2.0 1 1 0 1 1 1 1 Subunit 21 of Mediator complex Med26_C PF15693.5 EGD93735.1 - 0.011 15.9 2.4 0.013 15.6 2.4 1.1 1 0 0 1 1 1 0 Mediator complex subunit 26 C-terminal Spore_III_AB PF09548.10 EGD93735.1 - 0.061 13.4 0.7 0.11 12.6 0.7 1.4 1 0 0 1 1 1 0 Stage III sporulation protein AB (spore_III_AB) DUF4194 PF13835.6 EGD93735.1 - 0.087 12.6 3.0 0.12 12.1 3.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4194) TFIIA PF03153.13 EGD93735.1 - 0.11 12.5 8.9 0.13 12.3 8.9 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Spt20 PF12090.8 EGD93735.1 - 0.54 9.8 7.8 0.64 9.6 7.8 1.2 1 0 0 1 1 1 0 Spt20 family NINJA_B PF16136.5 EGD93735.1 - 1.5 9.2 10.3 3.1 8.2 1.0 2.2 2 0 0 2 2 2 0 Putative nuclear localisation signal SlyX PF04102.12 EGD93735.1 - 2.3 8.9 11.0 0.24 12.1 1.1 3.3 3 0 0 3 3 3 0 SlyX DUF4527 PF15030.6 EGD93735.1 - 5.3 6.4 10.4 0.07 12.5 2.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF4527) Med9 PF07544.13 EGD93735.1 - 5.9 7.1 10.2 0.087 12.9 1.4 2.5 2 1 0 2 2 1 0 RNA polymerase II transcription mediator complex subunit 9 DUF4175 PF13779.6 EGD93735.1 - 6.1 4.6 19.2 9.5 4.0 19.1 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4175) SNF2_N PF00176.23 EGD93736.1 - 9.6e-65 218.6 0.0 1.4e-64 218.0 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EGD93736.1 - 1.2e-11 44.9 0.0 7.4e-11 42.4 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 EGD93736.1 - 1.4e-05 25.0 0.0 4e-05 23.5 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase Prok-RING_4 PF14447.6 EGD93736.1 - 0.031 14.2 1.6 0.08 12.8 1.6 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 DUF896 PF05979.12 EGD93736.1 - 2.1 8.3 7.1 36 4.3 0.0 2.6 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF896) PI3_PI4_kinase PF00454.27 EGD93737.1 - 1e-45 156.5 0.0 7.6e-45 153.7 0.0 2.0 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase DUF1658 PF07871.11 EGD93737.1 - 0.019 14.9 2.2 3.1 7.9 1.1 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1658) EF-hand_1 PF00036.32 EGD93737.1 - 0.17 11.5 0.0 0.36 10.5 0.0 1.6 1 0 0 1 1 1 0 EF hand GATA PF00320.27 EGD93738.1 - 2.8e-15 55.6 2.5 5.2e-15 54.8 2.5 1.5 1 0 0 1 1 1 1 GATA zinc finger DivIVA PF05103.13 EGD93738.1 - 0.00047 20.2 2.2 0.00083 19.4 2.2 1.3 1 0 0 1 1 1 1 DivIVA protein DASH_Spc19 PF08287.11 EGD93738.1 - 0.015 15.2 5.9 0.038 13.9 5.9 1.7 1 0 0 1 1 1 0 Spc19 Pox_A_type_inc PF04508.12 EGD93738.1 - 0.028 14.3 1.8 0.34 10.8 0.7 2.4 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat TF_Zn_Ribbon PF08271.12 EGD93738.1 - 0.039 13.5 0.4 0.073 12.6 0.4 1.4 1 0 0 1 1 1 0 TFIIB zinc-binding CENP-F_N PF10481.9 EGD93738.1 - 0.042 13.5 5.2 2.7 7.6 1.6 2.3 1 1 1 2 2 2 0 Cenp-F N-terminal domain Auto_anti-p27 PF06677.12 EGD93738.1 - 0.046 13.9 0.9 0.073 13.2 0.9 1.3 1 0 0 1 1 1 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) DUF3461 PF11944.8 EGD93738.1 - 0.11 12.6 0.0 0.18 11.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3461) ArfGap PF01412.18 EGD93738.1 - 0.12 12.5 0.2 0.32 11.1 0.1 1.8 2 0 0 2 2 2 0 Putative GTPase activating protein for Arf DUF1465 PF07323.12 EGD93738.1 - 0.23 11.3 2.7 3.8 7.3 1.2 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1465) HAUS-augmin3 PF14932.6 EGD93738.1 - 0.71 9.4 7.6 1.4 8.5 7.6 1.4 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 Med4 PF10018.9 EGD93738.1 - 1.1 8.9 7.9 0.07 12.8 1.8 2.0 2 0 0 2 2 2 0 Vitamin-D-receptor interacting Mediator subunit 4 SlyX PF04102.12 EGD93738.1 - 4.7 7.9 5.5 14 6.4 5.5 1.8 1 0 0 1 1 1 0 SlyX Nodulin-like PF06813.13 EGD93739.1 - 2e-19 70.0 7.1 2e-19 70.0 7.1 1.9 2 1 0 2 2 2 1 Nodulin-like MFS_1 PF07690.16 EGD93739.1 - 1.2e-15 57.3 31.8 1.4e-12 47.2 10.5 2.6 2 1 1 3 3 3 2 Major Facilitator Superfamily Serinc PF03348.15 EGD93740.1 - 6.8e-139 463.5 16.2 9.2e-138 459.8 16.2 1.9 1 1 0 1 1 1 1 Serine incorporator (Serinc) Spem1 PF15670.5 EGD93740.1 - 1.6 8.2 4.0 4.2 6.9 1.8 2.1 1 1 1 2 2 2 0 Spermatid maturation protein 1 DUF4148 PF13663.6 EGD93740.1 - 1.8 8.8 5.3 0.46 10.7 0.6 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4148) DNA_mis_repair PF01119.19 EGD93741.1 - 8.4e-21 73.9 0.0 3.1e-19 68.8 0.0 2.6 2 0 0 2 2 2 1 DNA mismatch repair protein, C-terminal domain MutL_C PF08676.11 EGD93741.1 - 1.8e-19 70.0 2.1 3.6e-16 59.2 1.1 3.1 3 0 0 3 3 3 2 MutL C terminal dimerisation domain HATPase_c_3 PF13589.6 EGD93741.1 - 0.0001 22.2 0.0 0.00028 20.7 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 EGD93741.1 - 0.076 13.5 0.0 0.44 11.1 0.0 2.1 2 0 0 2 2 2 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DASH_Spc19 PF08287.11 EGD93741.1 - 4.2 7.2 7.4 0.84 9.5 0.5 2.7 1 1 1 3 3 3 0 Spc19 GCN5L1 PF06320.13 EGD93742.1 - 3.5e-17 62.6 1.6 5.7e-17 61.9 1.6 1.3 1 0 0 1 1 1 1 GCN5-like protein 1 (GCN5L1) DUF3552 PF12072.8 EGD93742.1 - 0.018 14.5 2.3 0.019 14.4 2.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) DASH_Dad2 PF08654.10 EGD93742.1 - 0.032 14.6 0.6 0.14 12.6 0.5 2.0 1 1 1 2 2 2 0 DASH complex subunit Dad2 Cellsynth_D PF03500.13 EGD93742.1 - 0.14 12.1 0.1 0.19 11.6 0.1 1.2 1 0 0 1 1 1 0 Cellulose synthase subunit D DivIC PF04977.15 EGD93742.1 - 0.3 10.9 2.3 0.56 10.0 2.3 1.4 1 0 0 1 1 1 0 Septum formation initiator Syntaxin-6_N PF09177.11 EGD93742.1 - 2 9.0 5.9 92 3.7 5.9 2.6 1 1 0 1 1 1 0 Syntaxin 6, N-terminal Sugar_tr PF00083.24 EGD93743.1 - 8.2e-83 278.7 27.9 9.3e-83 278.6 27.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EGD93743.1 - 2.1e-23 82.8 26.7 3.5e-22 78.8 24.7 2.0 2 0 0 2 2 2 2 Major Facilitator Superfamily PIG-Y PF15159.6 EGD93743.1 - 0.14 13.0 5.0 0.17 12.9 2.1 2.8 2 1 0 2 2 2 0 Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y FTA2 PF13095.6 EGD93746.1 - 1.5e-44 152.2 0.0 6.4e-42 143.6 0.0 2.8 2 1 0 2 2 2 1 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 EGD93746.1 - 0.14 12.1 0.0 0.36 10.7 0.0 1.7 2 0 0 2 2 2 0 Phosphotransferase enzyme family WD40 PF00400.32 EGD93747.1 - 3.3e-21 75.2 8.5 0.00074 20.3 0.0 8.3 8 0 0 8 8 8 6 WD domain, G-beta repeat DUF2812 PF11193.8 EGD93748.1 - 0.043 14.0 0.2 0.66 10.2 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2812) SPO22 PF08631.10 EGD93749.1 - 8.7e-12 45.1 2.6 9e-12 45.0 0.6 2.0 2 1 0 2 2 2 1 Meiosis protein SPO22/ZIP4 like Zn_clus PF00172.18 EGD93750.1 - 4.4e-06 26.7 10.6 8.2e-06 25.8 10.6 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CENP-Q PF13094.6 EGD93751.1 - 2.1e-41 141.9 7.5 3.3e-41 141.3 7.5 1.3 1 0 0 1 1 1 1 CENP-Q, a CENPA-CAD centromere complex subunit BRE1 PF08647.11 EGD93751.1 - 0.0098 15.9 10.3 0.029 14.4 10.3 1.8 1 0 0 1 1 1 1 BRE1 E3 ubiquitin ligase ZapB PF06005.12 EGD93751.1 - 0.012 16.1 12.1 0.012 16.1 12.1 2.6 3 1 0 3 3 3 0 Cell division protein ZapB Leu_zip PF15294.6 EGD93751.1 - 0.057 12.9 9.3 0.011 15.3 5.9 1.5 2 0 0 2 2 2 0 Leucine zipper HrpB7 PF09486.10 EGD93751.1 - 0.067 13.6 8.4 0.2 12.0 5.8 2.4 2 0 0 2 2 2 0 Bacterial type III secretion protein (HrpB7) DUF4407 PF14362.6 EGD93751.1 - 0.36 10.1 6.3 0.5 9.7 5.5 1.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) DUF4337 PF14235.6 EGD93751.1 - 1 9.5 4.5 2 8.5 4.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) DUF1840 PF08895.11 EGD93751.1 - 1.9 8.9 6.2 6.2 7.2 6.2 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF1840) Atg14 PF10186.9 EGD93751.1 - 2.4 7.2 6.6 0.76 8.8 3.7 1.6 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 Cep57_CLD_2 PF14197.6 EGD93751.1 - 2.9 8.1 16.6 20 5.4 0.1 3.4 2 1 1 3 3 3 0 Centrosome localisation domain of PPC89 TMF_TATA_bd PF12325.8 EGD93751.1 - 3.2 8.0 12.0 0.56 10.4 7.3 2.1 3 0 0 3 3 3 0 TATA element modulatory factor 1 TATA binding Spc24 PF08286.11 EGD93751.1 - 9.4 6.5 8.4 16 5.8 7.2 2.1 1 1 0 1 1 1 0 Spc24 subunit of Ndc80 APH PF01636.23 EGD93752.1 - 1.5e-18 67.6 0.0 3.8e-17 63.0 0.0 2.3 1 1 0 1 1 1 1 Phosphotransferase enzyme family DUF1679 PF07914.11 EGD93752.1 - 0.00012 21.1 0.1 0.047 12.6 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF1679) EcKinase PF02958.20 EGD93752.1 - 0.00044 19.7 0.0 0.00073 18.9 0.0 1.3 1 0 0 1 1 1 1 Ecdysteroid kinase Fructosamin_kin PF03881.14 EGD93752.1 - 0.049 12.8 0.0 1.2 8.3 0.0 2.1 2 0 0 2 2 2 0 Fructosamine kinase Pkinase PF00069.25 EGD93752.1 - 0.11 11.9 0.0 5.9 6.2 0.0 2.2 2 0 0 2 2 2 0 Protein kinase domain BTRD1 PF17660.1 EGD93753.1 - 1.2e-76 252.4 12.5 4.2e-16 58.5 0.3 5.0 5 0 0 5 5 5 5 Bacterial tandem repeat domain 1 Ser_hydrolase PF06821.13 EGD93753.1 - 0.0038 17.1 0.0 0.0066 16.3 0.0 1.4 1 0 0 1 1 1 1 Serine hydrolase UvrA_inter PF17760.1 EGD93753.1 - 0.043 13.9 0.1 1.7 8.7 0.0 3.0 2 1 1 3 3 3 0 UvrA interaction domain DUF4342 PF14242.6 EGD93753.1 - 0.17 11.9 0.0 0.33 11.0 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4342) DUF3884 PF13024.6 EGD93753.1 - 0.22 11.1 1.8 8.8 6.0 0.8 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3884) HLH PF00010.26 EGD93754.1 - 0.00043 20.2 0.1 0.0014 18.6 0.0 1.8 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain Sporozoite_P67 PF05642.11 EGD93754.1 - 2.7 6.0 9.7 4.2 5.3 9.7 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen SprA-related PF12118.8 EGD93754.1 - 8.6 5.4 15.3 5.3 6.1 2.5 2.2 2 0 0 2 2 2 0 SprA-related family TMEM135_C_rich PF15982.5 EGD93755.1 - 0.00091 19.8 1.8 0.0021 18.7 1.8 1.6 1 1 0 1 1 1 1 N-terminal cysteine-rich region of Transmembrane protein 135 Cation_ATPase_C PF00689.21 EGD93755.1 - 0.02 14.6 0.1 0.038 13.7 0.1 1.5 1 0 0 1 1 1 0 Cation transporting ATPase, C-terminus Semialdhyde_dhC PF02774.18 EGD93756.1 - 2.2e-37 128.9 0.0 3.3e-37 128.3 0.0 1.3 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, dimerisation domain Semialdhyde_dh PF01118.24 EGD93756.1 - 1.2e-29 103.2 0.0 5e-29 101.2 0.0 1.9 2 0 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain GFO_IDH_MocA PF01408.22 EGD93756.1 - 0.0021 18.9 0.0 0.0041 17.9 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold DapB_N PF01113.20 EGD93756.1 - 0.14 12.3 0.0 0.25 11.5 0.0 1.4 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus Peptidase_M35 PF02102.15 EGD93757.1 - 5.3e-106 354.5 4.6 6.2e-106 354.3 4.6 1.0 1 0 0 1 1 1 1 Deuterolysin metalloprotease (M35) family Aspzincin_M35 PF14521.6 EGD93757.1 - 9.9e-43 146.2 0.6 1.8e-42 145.3 0.6 1.4 1 0 0 1 1 1 1 Lysine-specific metallo-endopeptidase HRXXH PF13933.6 EGD93757.1 - 0.0005 19.7 0.5 0.0033 17.0 0.5 1.9 1 1 0 1 1 1 1 Putative peptidase family Polysacc_deac_1 PF01522.21 EGD93759.1 - 2.6e-27 95.2 0.0 4.6e-27 94.4 0.0 1.4 1 0 0 1 1 1 1 Polysaccharide deacetylase Glyco_hydro_57 PF03065.15 EGD93759.1 - 0.0097 15.1 0.0 0.014 14.6 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 57 DUF1444 PF07285.11 EGD93760.1 - 0.056 13.0 0.0 0.076 12.6 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1444) DUF2371 PF10177.9 EGD93760.1 - 0.072 13.3 0.0 0.11 12.6 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2371) CtaG_Cox11 PF04442.14 EGD93761.1 - 9.2e-62 207.5 0.1 1.3e-61 207.1 0.1 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein CtaG/Cox11 DNA_pol3_delta2 PF13177.6 EGD93762.1 - 1e-10 41.6 0.1 2e-10 40.7 0.1 1.5 1 1 0 1 1 1 1 DNA polymerase III, delta subunit AAA PF00004.29 EGD93762.1 - 8.6e-07 29.4 0.1 1.6e-06 28.6 0.1 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EGD93762.1 - 5.9e-06 26.6 0.1 1.5e-05 25.3 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EGD93762.1 - 0.00061 20.2 0.3 0.0046 17.3 0.2 2.3 2 1 0 2 2 2 1 AAA ATPase domain AAA_24 PF13479.6 EGD93762.1 - 0.0012 18.6 0.4 0.0031 17.3 0.4 1.6 1 1 0 1 1 1 1 AAA domain Rad17 PF03215.15 EGD93762.1 - 0.0065 16.4 0.0 0.057 13.3 0.0 2.1 2 0 0 2 2 2 1 Rad17 P-loop domain ABC_tran PF00005.27 EGD93762.1 - 0.021 15.4 0.1 0.045 14.3 0.1 1.7 1 1 0 1 1 1 0 ABC transporter Rep_fac_C PF08542.11 EGD93762.1 - 0.032 14.6 0.0 0.09 13.2 0.0 1.8 2 0 0 2 2 2 0 Replication factor C C-terminal domain T4SS-DNA_transf PF02534.14 EGD93762.1 - 0.072 11.9 0.0 0.12 11.2 0.0 1.3 1 0 0 1 1 1 0 Type IV secretory system Conjugative DNA transfer ResIII PF04851.15 EGD93762.1 - 0.11 12.5 0.2 0.61 10.1 0.2 1.9 1 1 1 2 2 2 0 Type III restriction enzyme, res subunit TK PF00265.18 EGD93762.1 - 0.19 11.6 0.7 0.91 9.4 0.7 1.9 1 1 0 1 1 1 0 Thymidine kinase Ribosomal_L16 PF00252.18 EGD93763.1 - 9.5e-31 106.5 0.1 1.4e-30 106.0 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e RFC1 PF08519.12 EGD93764.1 - 1.4e-58 197.5 0.2 9.4e-58 194.8 0.1 2.3 2 0 0 2 2 2 1 Replication factor RFC1 C terminal domain BRCT PF00533.26 EGD93764.1 - 2.1e-13 50.4 0.0 6.6e-13 48.9 0.0 2.0 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain AAA PF00004.29 EGD93764.1 - 2.3e-09 37.7 1.3 3.5e-09 37.2 0.1 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 EGD93764.1 - 0.00021 21.3 0.0 0.00047 20.1 0.0 1.5 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_22 PF13401.6 EGD93764.1 - 0.00073 19.8 0.0 0.0019 18.4 0.0 1.7 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.12 EGD93764.1 - 0.0029 17.4 0.0 0.006 16.4 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EGD93764.1 - 0.003 18.0 0.1 0.012 16.0 0.1 1.9 1 1 1 2 2 2 1 AAA ATPase domain AAA_14 PF13173.6 EGD93764.1 - 0.0072 16.4 0.0 0.018 15.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EGD93764.1 - 0.0076 16.4 0.0 0.021 15.0 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EGD93764.1 - 0.014 15.9 0.0 0.047 14.2 0.0 1.9 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 EGD93764.1 - 0.038 13.7 0.1 0.072 12.8 0.1 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_30 PF13604.6 EGD93764.1 - 0.044 13.5 0.0 0.12 12.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 EGD93764.1 - 0.064 13.2 0.1 0.4 10.7 0.0 2.4 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) NACHT PF05729.12 EGD93764.1 - 0.096 12.6 0.0 0.29 11.0 0.0 1.8 2 0 0 2 2 2 0 NACHT domain NAD_binding_8 PF13450.6 EGD93765.1 - 3.5e-14 52.8 0.1 2e-13 50.4 0.0 2.4 4 0 0 4 4 4 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.24 EGD93765.1 - 3.7e-13 49.6 0.0 6.9e-11 42.1 0.0 2.8 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase Pyr_redox_2 PF07992.14 EGD93765.1 - 0.0043 16.3 0.0 0.23 10.6 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EGD93765.1 - 0.01 15.9 0.0 0.24 11.4 0.0 2.7 2 0 0 2 2 2 1 FAD-NAD(P)-binding DAO PF01266.24 EGD93765.1 - 0.011 15.4 0.0 0.061 12.9 0.0 1.9 2 0 0 2 2 2 0 FAD dependent oxidoreductase Trp_halogenase PF04820.14 EGD93765.1 - 0.041 12.7 0.0 0.067 12.0 0.0 1.3 1 0 0 1 1 1 0 Tryptophan halogenase Homeodomain PF00046.29 EGD93765.1 - 0.14 12.0 0.1 5.5 6.9 0.0 2.3 2 0 0 2 2 2 0 Homeodomain Pyr_redox PF00070.27 EGD93765.1 - 0.18 12.4 0.0 13 6.5 0.0 2.6 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Septin PF00735.18 EGD93767.1 - 4.9e-119 396.8 0.1 4.9e-119 396.8 0.1 1.6 2 0 0 2 2 2 1 Septin MMR_HSR1 PF01926.23 EGD93767.1 - 1.3e-06 28.5 1.3 2.3e-06 27.7 0.0 2.0 2 1 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EGD93767.1 - 5.6e-05 23.1 0.2 5.6e-05 23.1 0.2 3.4 3 1 0 3 3 3 1 RsgA GTPase GTP_EFTU PF00009.27 EGD93767.1 - 0.00037 20.1 1.5 0.055 13.0 0.0 3.1 2 2 0 2 2 2 1 Elongation factor Tu GTP binding domain ABC_tran PF00005.27 EGD93767.1 - 0.00038 21.0 3.4 0.078 13.5 0.0 2.9 2 1 1 3 3 3 1 ABC transporter AAA_16 PF13191.6 EGD93767.1 - 0.0019 18.6 0.2 0.007 16.8 0.0 2.0 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 EGD93767.1 - 0.0034 17.6 0.5 0.022 15.0 0.0 2.5 2 2 0 2 2 2 1 AAA domain AAA_23 PF13476.6 EGD93767.1 - 0.0076 16.8 8.1 2.4 8.6 0.0 2.3 2 0 0 2 2 2 1 AAA domain Ras PF00071.22 EGD93767.1 - 0.02 14.5 0.0 0.081 12.5 0.0 2.0 1 1 0 1 1 1 0 Ras family Roc PF08477.13 EGD93767.1 - 0.034 14.4 0.0 0.087 13.1 0.0 1.7 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_29 PF13555.6 EGD93767.1 - 0.034 13.9 0.0 0.062 13.0 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Exonuc_VII_L PF02601.15 EGD93767.1 - 0.083 12.4 7.3 0.15 11.6 7.3 1.4 1 0 0 1 1 1 0 Exonuclease VII, large subunit ATP_bind_1 PF03029.17 EGD93767.1 - 0.29 10.9 5.0 1.2 8.9 0.0 3.1 2 1 1 3 3 3 0 Conserved hypothetical ATP binding protein Dynamin_N PF00350.23 EGD93767.1 - 0.65 10.0 7.2 13 5.8 0.0 3.7 3 1 0 3 3 3 0 Dynamin family DUF2937 PF11157.8 EGD93767.1 - 1.3 8.7 8.7 0.13 11.9 4.2 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2937) DUF87 PF01935.17 EGD93767.1 - 3.6 7.6 5.6 21 5.1 0.0 2.5 2 0 0 2 2 2 0 Helicase HerA, central domain SPESP1 PF15754.5 EGD93767.1 - 3.8 6.6 11.9 0.087 12.0 3.6 2.1 2 0 0 2 2 2 0 Sperm equatorial segment protein 1 Strep_SA_rep PF06696.11 EGD93767.1 - 3.8 7.6 5.7 3.3 7.8 3.7 1.9 1 1 1 2 2 2 0 Streptococcal surface antigen repeat Atg14 PF10186.9 EGD93767.1 - 5.1 6.1 9.0 7.7 5.5 9.0 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 UPF0121 PF03661.13 EGD93769.1 - 1.1e-25 90.5 1.4 1.4e-25 90.1 1.4 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0121) 7TM_GPCR_Str PF10326.9 EGD93769.1 - 0.014 14.7 2.2 0.04 13.3 0.4 2.0 2 0 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Str Mito_carr PF00153.27 EGD93770.1 - 4.4e-40 135.5 0.1 3.7e-19 68.4 0.1 2.2 2 0 0 2 2 2 2 Mitochondrial carrier protein DUF3496 PF12001.8 EGD93771.1 - 0.086 13.2 0.2 0.28 11.6 0.2 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF3496) CHCH PF06747.13 EGD93772.1 - 8.9e-07 28.9 5.3 1.5e-06 28.2 5.3 1.4 1 0 0 1 1 1 1 CHCH domain GCK PF07802.11 EGD93772.1 - 0.0043 17.4 2.0 0.01 16.2 2.0 1.8 1 1 0 1 1 1 1 GCK domain TPK_catalytic PF04263.16 EGD93773.1 - 3.1e-30 104.7 0.0 5.4e-30 103.9 0.0 1.3 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, catalytic domain TPK_B1_binding PF04265.14 EGD93773.1 - 3e-18 65.3 0.1 4.9e-18 64.6 0.1 1.3 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, vitamin B1 binding domain MIF4G PF02854.19 EGD93775.1 - 5.6e-54 183.0 0.0 1.6e-27 96.5 0.0 4.2 4 1 0 4 4 4 2 MIF4G domain Upf2 PF04050.14 EGD93775.1 - 1.8e-40 138.8 13.3 1.8e-40 138.8 13.3 2.7 2 0 0 2 2 2 1 Up-frameshift suppressor 2 FliD_C PF07195.12 EGD93775.1 - 0.034 13.6 0.8 0.079 12.4 0.8 1.5 1 0 0 1 1 1 0 Flagellar hook-associated protein 2 C-terminus TraF PF13728.6 EGD93775.1 - 3.6 7.3 13.5 5.1 6.8 2.2 3.6 3 0 0 3 3 3 0 F plasmid transfer operon protein DUF1515 PF07439.11 EGD93776.1 - 0.01 15.9 0.3 0.047 13.7 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1515) WDCP PF15390.6 EGD93776.1 - 0.013 13.9 0.1 0.016 13.6 0.1 1.0 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family ATG16 PF08614.11 EGD93776.1 - 0.016 15.4 0.7 0.036 14.3 0.4 1.6 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) CENP-F_leu_zip PF10473.9 EGD93776.1 - 0.073 13.1 0.9 0.29 11.1 0.5 1.8 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 CorA PF01544.18 EGD93776.1 - 0.15 11.4 0.1 0.19 11.0 0.1 1.1 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein Yuri_gagarin PF15934.5 EGD93776.1 - 0.24 11.2 1.9 0.33 10.8 1.9 1.1 1 0 0 1 1 1 0 Yuri gagarin FMO-like PF00743.19 EGD93777.1 - 2.8e-18 65.7 0.1 3.6e-17 62.0 0.1 2.2 1 1 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 EGD93777.1 - 1e-12 48.0 0.0 7.5e-12 45.1 0.0 2.4 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EGD93777.1 - 1.7e-09 37.8 0.0 3.9e-09 36.6 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.6 EGD93777.1 - 6.8e-08 32.0 0.1 6.3e-06 25.6 0.0 2.8 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.14 EGD93777.1 - 9.4e-08 31.6 0.0 1.7e-05 24.3 0.0 2.5 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EGD93777.1 - 3.8e-05 23.4 0.0 0.00021 21.0 0.0 2.0 2 0 0 2 2 2 1 FAD dependent oxidoreductase Shikimate_DH PF01488.20 EGD93777.1 - 0.0006 19.9 0.0 0.12 12.4 0.0 2.5 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase Thi4 PF01946.17 EGD93777.1 - 0.0098 15.2 0.2 0.017 14.3 0.2 1.3 1 0 0 1 1 1 1 Thi4 family FAD_binding_2 PF00890.24 EGD93777.1 - 0.024 13.7 0.3 0.034 13.2 0.3 1.2 1 0 0 1 1 1 0 FAD binding domain NAD_binding_9 PF13454.6 EGD93777.1 - 0.03 14.3 0.0 0.16 12.0 0.0 2.2 3 0 0 3 3 3 0 FAD-NAD(P)-binding MrpF_PhaF PF04066.13 EGD93777.1 - 0.035 14.5 0.0 0.066 13.6 0.0 1.4 1 0 0 1 1 1 0 Multiple resistance and pH regulation protein F (MrpF / PhaF) FAD_oxidored PF12831.7 EGD93777.1 - 0.1 11.9 0.1 0.17 11.2 0.1 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase HI0933_like PF03486.14 EGD93777.1 - 0.46 9.1 1.4 0.8 8.3 1.4 1.3 1 0 0 1 1 1 0 HI0933-like protein Glyco_hydro_18 PF00704.28 EGD93778.1 - 6e-85 285.7 0.2 7.2e-85 285.4 0.2 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 LysM PF01476.20 EGD93778.1 - 1.8e-12 47.1 0.1 3.5e-12 46.2 0.1 1.5 1 0 0 1 1 1 1 LysM domain Glyco_transf_8 PF01501.20 EGD93779.1 - 1e-13 51.4 0.0 1.3e-13 51.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 8 Mannosyl_trans3 PF11051.8 EGD93779.1 - 0.063 12.6 0.0 0.11 11.8 0.0 1.4 1 0 0 1 1 1 0 Mannosyltransferase putative APH PF01636.23 EGD93780.1 - 1.2e-10 41.8 0.0 2.9e-10 40.5 0.0 1.6 1 1 0 1 1 1 1 Phosphotransferase enzyme family SUN PF03856.13 EGD93783.1 - 5.6e-90 301.1 4.9 7.2e-90 300.7 4.9 1.1 1 0 0 1 1 1 1 Beta-glucosidase (SUN family) Ribosomal_L1 PF00687.21 EGD93784.1 - 5.8e-57 192.7 0.2 5.8e-57 192.7 0.2 1.6 2 0 0 2 2 2 1 Ribosomal protein L1p/L10e family RNA_pol_3_Rpc31 PF11705.8 EGD93784.1 - 4 7.6 11.2 0.47 10.7 4.7 2.4 3 0 0 3 3 3 0 DNA-directed RNA polymerase III subunit Rpc31 ETF PF01012.21 EGD93785.1 - 7.8e-41 140.0 2.0 1.5e-40 139.1 2.0 1.5 1 0 0 1 1 1 1 Electron transfer flavoprotein domain ETF_alpha PF00766.19 EGD93785.1 - 2.1e-33 114.2 0.1 6.1e-33 112.7 0.1 1.8 1 0 0 1 1 1 1 Electron transfer flavoprotein FAD-binding domain Kdo PF06293.14 EGD93787.1 - 6.6e-07 28.9 0.1 1.5e-06 27.7 0.1 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.25 EGD93787.1 - 7.4e-05 22.2 0.0 0.00029 20.3 0.0 2.0 2 0 0 2 2 2 1 Protein kinase domain APH PF01636.23 EGD93787.1 - 7.9e-05 22.7 0.2 7.9e-05 22.7 0.2 2.7 2 1 1 3 3 3 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EGD93787.1 - 0.018 14.6 0.0 0.041 13.4 0.0 1.5 1 0 0 1 1 1 0 Choline/ethanolamine kinase RIO1 PF01163.22 EGD93787.1 - 0.092 12.3 0.0 0.27 10.8 0.0 1.8 1 0 0 1 1 1 0 RIO1 family AAA PF00004.29 EGD93790.1 - 8.6e-12 45.6 0.0 1.6e-11 44.8 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EGD93790.1 - 4.1e-06 27.1 0.0 9.9e-06 25.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain Rad17 PF03215.15 EGD93790.1 - 4.9e-06 26.6 0.0 9.4e-06 25.7 0.0 1.4 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_5 PF07728.14 EGD93790.1 - 6.3e-06 26.2 0.0 1.2e-05 25.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 EGD93790.1 - 1.9e-05 24.4 0.0 3.8e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_14 PF13173.6 EGD93790.1 - 0.001 19.1 0.0 0.0019 18.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EGD93790.1 - 0.0026 17.9 0.0 0.0062 16.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EGD93790.1 - 0.0029 18.0 0.0 0.012 16.0 0.0 1.9 2 0 0 2 2 2 1 AAA ATPase domain NTPase_1 PF03266.15 EGD93790.1 - 0.032 14.1 0.1 0.07 13.0 0.1 1.6 1 0 0 1 1 1 0 NTPase DUF1776 PF08643.10 EGD93790.1 - 0.039 13.3 0.0 0.059 12.7 0.0 1.2 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) Zeta_toxin PF06414.12 EGD93790.1 - 0.039 13.2 0.0 0.081 12.2 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_19 PF13245.6 EGD93790.1 - 0.074 13.4 0.4 0.29 11.5 0.0 2.1 2 0 0 2 2 2 0 AAA domain TsaE PF02367.17 EGD93790.1 - 0.098 12.7 0.0 0.2 11.7 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE RsgA_GTPase PF03193.16 EGD93790.1 - 0.13 12.2 1.0 0.24 11.3 0.0 1.9 2 0 0 2 2 2 0 RsgA GTPase Lebercilin PF15619.6 EGD93791.1 - 0.00047 19.9 1.2 0.34 10.5 0.0 2.8 1 1 1 2 2 2 2 Ciliary protein causing Leber congenital amaurosis disease Spc7 PF08317.11 EGD93791.1 - 0.0031 16.5 6.7 0.007 15.3 6.5 1.6 1 1 0 1 1 1 1 Spc7 kinetochore protein Filament PF00038.21 EGD93791.1 - 0.0057 16.3 4.6 0.01 15.5 4.6 1.4 1 0 0 1 1 1 1 Intermediate filament protein Mating_N PF12731.7 EGD93791.1 - 0.026 14.6 2.3 0.073 13.2 0.7 2.4 1 1 1 2 2 2 0 Mating-type protein beta 1 FAM184 PF15665.5 EGD93791.1 - 0.04 13.7 2.7 0.091 12.5 2.7 1.6 1 0 0 1 1 1 0 Family with sequence similarity 184, A and B TolA_bind_tri PF16331.5 EGD93791.1 - 0.063 13.4 5.6 1.5 8.9 0.0 2.9 2 1 0 2 2 2 0 TolA binding protein trimerisation THOC7 PF05615.13 EGD93791.1 - 0.067 13.5 4.3 0.16 12.2 4.3 1.7 1 0 0 1 1 1 0 Tho complex subunit 7 EzrA PF06160.12 EGD93791.1 - 0.068 11.3 3.6 0.1 10.8 3.6 1.2 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA Tropomyosin PF00261.20 EGD93791.1 - 0.12 11.7 6.2 0.53 9.6 2.0 2.7 1 1 1 2 2 2 0 Tropomyosin Matrilin_ccoil PF10393.9 EGD93791.1 - 0.23 11.3 5.7 13 5.7 0.0 4.0 4 0 0 4 4 4 0 Trimeric coiled-coil oligomerisation domain of matrilin Baculo_PEP_C PF04513.12 EGD93791.1 - 0.34 10.9 11.3 2.6 8.1 0.5 2.5 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Phage_Mu_Gam PF07352.12 EGD93791.1 - 0.82 9.6 6.2 2 8.3 2.3 2.4 2 0 0 2 2 2 0 Bacteriophage Mu Gam like protein FAM76 PF16046.5 EGD93791.1 - 1.3 8.3 8.2 1.9 7.8 7.9 1.6 1 1 0 1 1 1 0 FAM76 protein DUF724 PF05266.14 EGD93791.1 - 1.5 8.6 6.8 0.23 11.3 1.9 2.1 2 1 1 3 3 3 0 Protein of unknown function (DUF724) DUF3450 PF11932.8 EGD93791.1 - 1.6 8.0 9.4 14 4.9 0.1 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) Snapin_Pallidin PF14712.6 EGD93791.1 - 2 8.9 7.2 2.8 8.4 0.6 3.2 2 1 1 3 3 3 0 Snapin/Pallidin Exonuc_VII_L PF02601.15 EGD93791.1 - 2.1 7.9 7.9 0.26 10.8 3.8 1.6 2 0 0 2 2 2 0 Exonuclease VII, large subunit SlyX PF04102.12 EGD93791.1 - 2.6 8.7 6.8 3.5 8.3 1.2 3.7 1 1 2 3 3 3 0 SlyX TMF_DNA_bd PF12329.8 EGD93791.1 - 3.3 7.8 7.7 16 5.6 0.3 3.3 3 1 0 3 3 3 0 TATA element modulatory factor 1 DNA binding ABC_tran_CTD PF16326.5 EGD93791.1 - 3.7 7.9 5.4 20 5.5 3.4 3.1 2 1 1 3 3 2 0 ABC transporter C-terminal domain Fib_alpha PF08702.10 EGD93791.1 - 4.2 7.6 9.2 1.6 8.9 2.3 2.6 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family AAA_13 PF13166.6 EGD93791.1 - 4.5 5.8 9.0 0.97 8.0 4.4 1.8 2 0 0 2 2 2 0 AAA domain SWIRM PF04433.17 EGD93792.1 - 6.2e-31 106.6 0.0 1.5e-30 105.3 0.0 1.7 1 0 0 1 1 1 1 SWIRM domain SWIRM-assoc_1 PF16495.5 EGD93792.1 - 1.9e-30 104.6 8.5 4.9e-30 103.3 8.5 1.7 1 0 0 1 1 1 1 SWIRM-associated region 1 Myb_DNA-binding PF00249.31 EGD93792.1 - 1.4e-09 37.9 0.1 2.6e-09 37.1 0.1 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EGD93792.1 - 6e-06 26.4 0.2 1.3e-05 25.3 0.2 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain ZZ PF00569.17 EGD93792.1 - 1.8 8.4 4.5 0.66 9.8 0.1 2.0 2 0 0 2 2 2 0 Zinc finger, ZZ type RR_TM4-6 PF06459.12 EGD93793.1 - 0.43 10.4 17.1 0.78 9.5 17.1 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 NOA36 PF06524.12 EGD93793.1 - 1 8.6 7.8 2.2 7.5 7.8 1.5 1 0 0 1 1 1 0 NOA36 protein Pkinase_Tyr PF07714.17 EGD93794.1 - 2.6e-09 36.8 0.0 4.1e-09 36.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EGD93794.1 - 8.5e-08 31.9 0.0 2.5e-07 30.3 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain APH PF01636.23 EGD93794.1 - 4.9e-07 29.9 0.0 2.9e-05 24.1 0.1 2.3 1 1 0 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EGD93794.1 - 0.057 13.0 0.0 0.33 10.5 0.0 1.9 1 1 1 2 2 2 0 Choline/ethanolamine kinase Seadorna_VP7 PF07387.11 EGD93794.1 - 0.068 12.2 0.0 0.11 11.6 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Kinase-like PF14531.6 EGD93794.1 - 0.1 11.9 0.0 0.14 11.4 0.0 1.2 1 0 0 1 1 1 0 Kinase-like RIO1 PF01163.22 EGD93794.1 - 0.11 12.1 0.0 0.17 11.4 0.0 1.2 1 0 0 1 1 1 0 RIO1 family Pkinase_fungal PF17667.1 EGD93794.1 - 0.22 10.2 0.0 0.29 9.8 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase ResIII PF04851.15 EGD93795.1 - 3e-25 89.2 0.0 5.4e-25 88.4 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EGD93795.1 - 1.4e-13 51.1 0.0 1.3e-12 48.1 0.0 2.3 2 1 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 EGD93795.1 - 4.5e-11 42.8 0.0 8.2e-11 42.0 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase SWI2_SNF2 PF18766.1 EGD93795.1 - 3.5e-06 26.9 0.0 5.9e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 SWI2/SNF2 ATPase DUF2075 PF09848.9 EGD93795.1 - 7.2e-05 22.2 0.0 0.00012 21.5 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) UvrD-helicase PF00580.21 EGD93795.1 - 0.069 12.7 0.4 1.2 8.6 0.0 2.2 1 1 0 2 2 2 0 UvrD/REP helicase N-terminal domain T2SSE PF00437.20 EGD93795.1 - 0.1 11.7 0.0 0.17 10.9 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein Ank_2 PF12796.7 EGD93796.1 - 3.8e-11 43.4 0.0 6.4e-06 26.7 0.0 2.8 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EGD93796.1 - 3.2e-08 33.2 0.1 0.91 10.3 0.0 4.5 4 0 0 4 4 4 2 Ankyrin repeat Ank_4 PF13637.6 EGD93796.1 - 1.2e-07 32.1 0.1 0.089 13.4 0.0 4.0 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 EGD93796.1 - 1.7e-07 31.4 0.4 0.1 13.1 0.0 4.6 5 0 0 5 5 5 2 Ankyrin repeat Glyco_transf_90 PF05686.12 EGD93798.1 - 7.3e-28 97.6 1.2 9.8e-28 97.2 1.2 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 90 Glyco_trans_1_2 PF13524.6 EGD93798.1 - 0.052 13.9 0.1 0.12 12.8 0.1 1.6 1 0 0 1 1 1 0 Glycosyl transferases group 1 PGAP1 PF07819.13 EGD93799.1 - 1.7e-85 286.4 0.0 2.5e-85 285.9 0.0 1.3 1 0 0 1 1 1 1 PGAP1-like protein Abhydrolase_6 PF12697.7 EGD93799.1 - 5.6e-05 23.8 0.1 0.0001 23.0 0.1 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family Palm_thioest PF02089.15 EGD93799.1 - 0.00054 19.9 0.0 0.00087 19.2 0.0 1.3 1 0 0 1 1 1 1 Palmitoyl protein thioesterase Abhydrolase_1 PF00561.20 EGD93799.1 - 0.00067 19.4 0.3 0.0019 17.9 0.3 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Esterase PF00756.20 EGD93799.1 - 0.0023 17.6 0.0 0.0042 16.8 0.0 1.3 1 0 0 1 1 1 1 Putative esterase Hydrolase_4 PF12146.8 EGD93799.1 - 0.0056 16.0 0.0 0.011 15.0 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 LCAT PF02450.15 EGD93799.1 - 0.0057 15.9 0.0 0.0098 15.1 0.0 1.3 1 0 0 1 1 1 1 Lecithin:cholesterol acyltransferase DUF676 PF05057.14 EGD93799.1 - 0.019 14.5 0.0 0.035 13.6 0.0 1.3 1 0 0 1 1 1 0 Putative serine esterase (DUF676) Peptidase_M28 PF04389.17 EGD93800.1 - 1.8e-27 96.3 0.1 5.3e-27 94.8 0.1 1.7 1 1 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.28 EGD93800.1 - 1.1e-07 31.8 0.0 1.5e-07 31.4 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 Peptidase_M42 PF05343.14 EGD93800.1 - 0.00041 19.5 0.0 0.001 18.2 0.0 1.7 1 1 0 1 1 1 1 M42 glutamyl aminopeptidase fn3 PF00041.21 EGD93800.1 - 0.038 14.3 0.0 0.081 13.3 0.0 1.5 1 0 0 1 1 1 0 Fibronectin type III domain Nicastrin PF05450.15 EGD93800.1 - 0.091 12.2 0.0 0.13 11.7 0.0 1.2 1 0 0 1 1 1 0 Nicastrin HlyIII PF03006.20 EGD93801.1 - 3.9e-11 43.1 4.3 6.5e-08 32.6 0.8 2.1 1 1 1 2 2 2 2 Haemolysin-III related 2TM PF13239.6 EGD93801.1 - 0.051 13.9 0.1 0.093 13.1 0.1 1.4 1 0 0 1 1 1 0 2TM domain NAD_binding_10 PF13460.6 EGD93803.1 - 5.8e-11 42.6 0.1 1.9e-10 41.0 0.1 1.9 1 1 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 EGD93803.1 - 6.1e-05 22.7 0.3 0.00027 20.6 0.1 1.9 2 0 0 2 2 2 1 NmrA-like family adh_short PF00106.25 EGD93803.1 - 0.0016 17.9 0.2 0.0026 17.3 0.2 1.3 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EGD93803.1 - 0.024 14.5 0.0 0.039 13.9 0.0 1.2 1 0 0 1 1 1 0 KR domain HSDR_N PF04313.14 EGD93803.1 - 0.095 12.6 0.0 0.15 12.0 0.0 1.2 1 0 0 1 1 1 0 Type I restriction enzyme R protein N terminus (HSDR_N) APG17 PF04108.12 EGD93806.1 - 6.4e-128 427.2 0.5 7.6e-128 427.0 0.5 1.1 1 0 0 1 1 1 1 Autophagy protein Apg17 Tweety PF04906.13 EGD93806.1 - 0.016 13.9 1.0 0.26 9.9 0.0 2.5 3 0 0 3 3 3 0 Tweety DUF4795 PF16043.5 EGD93806.1 - 2.4 7.7 7.0 0.44 10.1 0.3 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4795) 7TMR-HDED PF07697.11 EGD93806.1 - 5.4 7.1 9.6 5.4 7.1 7.0 2.5 1 1 1 2 2 2 0 7TM-HD extracellular WD40 PF00400.32 EGD93807.1 - 5.4e-46 153.6 21.8 5.7e-09 36.5 0.5 8.1 8 0 0 8 8 8 6 WD domain, G-beta repeat F-box-like PF12937.7 EGD93807.1 - 3.5e-15 55.6 0.4 7.4e-15 54.6 0.4 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EGD93807.1 - 1.9e-11 43.5 0.3 5.1e-11 42.2 0.1 1.9 2 0 0 2 2 2 1 F-box domain Nup160 PF11715.8 EGD93807.1 - 4.4e-10 38.8 7.5 0.062 11.9 0.2 5.7 4 2 1 6 6 6 4 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 EGD93807.1 - 7e-09 35.9 0.5 0.0013 18.9 0.0 4.5 1 1 3 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EGD93807.1 - 0.0012 18.3 0.2 0.0021 17.5 0.2 1.3 1 0 0 1 1 1 1 WD40-like domain F-box_4 PF15966.5 EGD93807.1 - 0.0012 18.7 0.1 0.0038 17.1 0.0 1.9 2 0 0 2 2 2 1 F-box Arm PF00514.23 EGD93810.1 - 0.11 12.6 0.8 0.2 11.7 0.8 1.4 1 0 0 1 1 1 0 Armadillo/beta-catenin-like repeat CENP-Q PF13094.6 EGD93812.1 - 0.048 13.9 0.3 0.091 13.0 0.3 1.4 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit Caskin-tail PF16632.5 EGD93812.1 - 0.12 12.8 4.8 0.16 12.4 0.1 2.5 2 0 0 2 2 2 0 C-terminal region of Caskin RIO1 PF01163.22 EGD93813.1 - 2.1e-72 242.7 0.1 2.1e-72 242.7 0.1 1.8 2 0 0 2 2 2 1 RIO1 family APH PF01636.23 EGD93813.1 - 2.5e-05 24.3 0.2 0.0062 16.5 0.1 2.5 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 EGD93813.1 - 0.0026 17.1 0.6 0.031 13.6 0.6 2.2 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 EGD93813.1 - 0.084 12.4 0.8 0.19 11.3 0.2 1.8 2 0 0 2 2 2 0 Choline/ethanolamine kinase DUF3464 PF11947.8 EGD93813.1 - 0.19 11.5 2.6 0.55 10.0 2.6 1.7 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 Kinase-PolyVal PF18762.1 EGD93813.1 - 0.28 11.1 1.6 0.54 10.2 0.1 2.2 3 0 0 3 3 3 0 Serine/Threonine/Tyrosine Kinase found in polyvalent proteins Pkinase_fungal PF17667.1 EGD93813.1 - 0.6 8.8 4.5 0.1 11.4 0.4 1.7 2 0 0 2 2 2 0 Fungal protein kinase SMC_N PF02463.19 EGD93814.1 - 1.7e-66 223.9 21.1 4e-66 222.6 21.1 1.9 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 EGD93814.1 - 4.3e-32 110.9 0.3 6.9e-31 107.0 0.0 3.0 3 0 0 3 3 3 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 EGD93814.1 - 7.4e-20 72.0 4.5 6.8e-12 45.8 0.2 3.4 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 EGD93814.1 - 4.2e-18 66.6 4.8 4.2e-18 66.6 4.8 6.6 2 2 3 5 5 5 1 AAA domain AAA_15 PF13175.6 EGD93814.1 - 1.4e-14 54.6 47.3 6.7e-11 42.5 7.8 4.2 2 2 1 3 3 3 2 AAA ATPase domain AAA_29 PF13555.6 EGD93814.1 - 0.0054 16.5 0.0 0.012 15.3 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain APG6_N PF17675.1 EGD93814.1 - 0.096 13.2 133.7 0.038 14.5 11.7 8.1 4 2 4 8 8 8 0 Apg6 coiled-coil region ABC_tran PF00005.27 EGD93814.1 - 0.47 11.0 0.0 0.47 11.0 0.0 6.1 4 2 0 4 4 4 0 ABC transporter DUF87 PF01935.17 EGD93814.1 - 2.8 8.0 0.0 2.8 8.0 0.0 6.3 3 2 2 5 5 5 0 Helicase HerA, central domain DUF3605 PF12239.8 EGD93815.1 - 8.3e-61 204.8 0.3 9.8e-61 204.6 0.3 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3605) Dfp1_Him1_M PF08630.10 EGD93815.1 - 0.11 12.7 0.0 0.67 10.2 0.0 2.1 2 0 0 2 2 2 0 Dfp1/Him1, central region FAD_binding_6 PF00970.24 EGD93816.1 - 4.8e-32 110.2 0.0 8e-32 109.5 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.21 EGD93816.1 - 3.9e-28 98.3 0.0 6.2e-28 97.6 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.12 EGD93816.1 - 1.8e-05 24.9 0.0 0.0018 18.4 0.0 2.2 2 0 0 2 2 2 1 Ferric reductase NAD binding domain DUF4176 PF13780.6 EGD93816.1 - 0.017 15.2 0.0 0.041 13.9 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4176) FAD_binding_9 PF08021.11 EGD93816.1 - 0.068 13.4 0.0 0.14 12.4 0.0 1.5 1 0 0 1 1 1 0 Siderophore-interacting FAD-binding domain WD40 PF00400.32 EGD93817.1 - 8.4e-11 42.3 17.9 9.5e-05 23.1 0.3 7.0 7 0 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EGD93817.1 - 8.4e-05 22.8 0.3 2.6 8.4 0.0 4.8 4 1 0 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EGD93817.1 - 0.1 11.6 0.7 0.38 9.7 0.1 2.2 2 1 1 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein tRNA-synt_1d PF00750.19 EGD93818.1 - 8.6e-96 320.9 8.7 3.4e-94 315.6 8.7 2.0 1 1 0 1 1 1 1 tRNA synthetases class I (R) DALR_1 PF05746.15 EGD93818.1 - 8.8e-29 100.1 0.0 2.2e-28 98.8 0.0 1.7 1 0 0 1 1 1 1 DALR anticodon binding domain Arg_tRNA_synt_N PF03485.16 EGD93818.1 - 1.1e-05 26.0 0.8 5.1e-05 23.8 0.0 2.5 2 0 0 2 2 2 1 Arginyl tRNA synthetase N terminal domain DUF16 PF01519.16 EGD93818.1 - 0.059 13.9 4.3 0.38 11.3 0.8 2.5 2 0 0 2 2 2 0 Protein of unknown function DUF16 Kelch_4 PF13418.6 EGD93820.1 - 2.6e-05 24.1 0.4 0.028 14.4 0.0 3.3 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_3 PF13415.6 EGD93820.1 - 0.00082 19.6 2.6 0.9 9.9 0.1 4.3 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_5 PF13854.6 EGD93820.1 - 0.00083 19.3 0.0 0.063 13.3 0.0 3.1 3 0 0 3 3 3 1 Kelch motif Kelch_6 PF13964.6 EGD93820.1 - 0.00094 19.4 0.2 0.27 11.6 0.0 4.1 5 0 0 5 5 5 1 Kelch motif Mid2 PF04478.12 EGD93820.1 - 0.0022 17.9 0.0 0.0053 16.6 0.0 1.6 1 0 0 1 1 1 1 Mid2 like cell wall stress sensor Kelch_2 PF07646.15 EGD93820.1 - 0.0033 17.3 1.2 0.75 9.9 0.0 4.0 3 0 0 3 3 3 1 Kelch motif SKG6 PF08693.10 EGD93820.1 - 0.04 13.3 4.4 0.081 12.3 4.4 1.4 1 0 0 1 1 1 0 Transmembrane alpha-helix domain BPL_LplA_LipB PF03099.19 EGD93821.1 - 7.7e-05 22.6 0.0 0.00014 21.7 0.0 1.4 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family Chorismate_synt PF01264.21 EGD93822.1 - 1.5e-139 464.3 0.0 1.7e-139 464.1 0.0 1.0 1 0 0 1 1 1 1 Chorismate synthase Ima1_N PF09779.9 EGD93823.1 - 4.6e-37 127.9 7.0 4.6e-37 127.9 7.0 1.8 2 0 0 2 2 2 1 Ima1 N-terminal domain OrfB_Zn_ribbon PF07282.11 EGD93823.1 - 0.26 11.2 3.0 0.29 11.1 0.8 2.2 2 0 0 2 2 2 0 Putative transposase DNA-binding domain DZR PF12773.7 EGD93823.1 - 0.31 11.1 4.0 8 6.6 0.2 2.6 2 0 0 2 2 2 0 Double zinc ribbon Zn_Tnp_IS1595 PF12760.7 EGD93823.1 - 0.84 9.7 11.0 0.063 13.3 4.3 2.5 3 0 0 3 3 3 0 Transposase zinc-ribbon domain zf-Sec23_Sec24 PF04810.15 EGD93823.1 - 3.5 7.8 4.9 1.2 9.2 0.9 2.4 2 0 0 2 2 2 0 Sec23/Sec24 zinc finger Alg14 PF08660.11 EGD93824.1 - 2.7e-42 144.7 0.0 3.6e-42 144.3 0.0 1.2 1 0 0 1 1 1 1 Oligosaccharide biosynthesis protein Alg14 like PNK3P PF08645.11 EGD93827.1 - 1.6e-54 183.9 0.2 3.1e-54 183.0 0.1 1.5 2 0 0 2 2 2 1 Polynucleotide kinase 3 phosphatase AAA_33 PF13671.6 EGD93827.1 - 2.9e-26 92.4 0.0 7.1e-24 84.6 0.0 2.5 1 1 0 1 1 1 1 AAA domain KTI12 PF08433.10 EGD93827.1 - 6.9e-08 32.3 1.2 0.00014 21.4 0.1 2.3 1 1 1 2 2 2 2 Chromatin associated protein KTI12 AAA_29 PF13555.6 EGD93827.1 - 0.039 13.7 0.2 0.33 10.7 0.0 2.5 3 0 0 3 3 3 0 P-loop containing region of AAA domain Zeta_toxin PF06414.12 EGD93827.1 - 0.055 12.7 0.0 0.11 11.8 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin AAA_16 PF13191.6 EGD93827.1 - 0.072 13.5 0.0 0.14 12.6 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain G-alpha PF00503.20 EGD93827.1 - 0.073 12.2 0.1 3 6.9 0.1 2.1 1 1 1 2 2 2 0 G-protein alpha subunit AAA_18 PF13238.6 EGD93827.1 - 0.075 13.6 0.0 0.14 12.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain PGP_phosphatase PF09419.10 EGD93827.1 - 0.091 12.4 0.1 0.2 11.3 0.1 1.5 1 0 0 1 1 1 0 Mitochondrial PGP phosphatase CgtA PF06306.11 EGD93827.1 - 0.16 11.4 0.1 0.28 10.6 0.1 1.3 1 0 0 1 1 1 0 Beta-1,4-N-acetylgalactosaminyltransferase (CgtA) Med18 PF09637.10 EGD93828.1 - 5.3e-34 118.2 0.0 1.7e-16 60.8 0.0 2.0 1 1 1 2 2 2 2 Med18 protein S36_mt PF10937.8 EGD93829.1 - 1.4e-42 145.9 0.5 1.6e-42 145.7 0.5 1.1 1 0 0 1 1 1 1 Ribosomal protein S36, mitochondrial DUF647 PF04884.14 EGD93830.1 - 2.5e-70 236.8 0.3 4.8e-70 235.9 0.3 1.4 1 0 0 1 1 1 1 Vitamin B6 photo-protection and homoeostasis RGS PF00615.19 EGD93833.1 - 3e-11 43.6 0.0 4.6e-11 43.0 0.0 1.2 1 0 0 1 1 1 1 Regulator of G protein signaling domain Pkinase PF00069.25 EGD93835.1 - 1.3e-27 96.8 0.0 1.7e-27 96.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD93835.1 - 2.3e-14 53.3 0.0 3.2e-14 52.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EGD93835.1 - 1.9e-07 30.2 0.1 2.7e-07 29.7 0.1 1.2 1 0 0 1 1 1 1 Fungal protein kinase AICARFT_IMPCHas PF01808.18 EGD93836.1 - 3.8e-89 299.1 0.0 7.7e-89 298.0 0.0 1.5 1 0 0 1 1 1 1 AICARFT/IMPCHase bienzyme MGS PF02142.22 EGD93836.1 - 4.9e-25 87.5 0.1 9.1e-25 86.7 0.1 1.5 1 0 0 1 1 1 1 MGS-like domain Rtt106 PF08512.12 EGD93837.1 - 9.9e-31 106.0 0.0 1.9e-30 105.1 0.0 1.5 1 0 0 1 1 1 1 Histone chaperone Rttp106-like PH_18 PF18469.1 EGD93837.1 - 0.012 15.6 0.0 0.074 13.0 0.0 2.1 2 0 0 2 2 2 0 Pleckstrin homology domain PPP4R2 PF09184.11 EGD93837.1 - 6.9 6.2 13.9 10 5.6 13.9 1.3 1 0 0 1 1 1 0 PPP4R2 KOW PF00467.29 EGD93838.1 - 2.1e-06 27.5 0.5 4.2e-06 26.5 0.5 1.5 1 0 0 1 1 1 1 KOW motif SH3_13 PF18335.1 EGD93838.1 - 0.13 12.1 1.1 0.29 11.0 0.0 2.1 2 0 0 2 2 2 0 ATP-dependent RecD-like DNA helicase SH3 domain Ras PF00071.22 EGD93839.1 - 3.3e-44 150.4 0.0 4.1e-44 150.0 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EGD93839.1 - 7.5e-22 77.8 0.0 1.1e-21 77.3 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EGD93839.1 - 2.6e-05 23.7 0.0 4e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 EGD93839.1 - 0.0054 16.2 0.0 0.0074 15.7 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MGC-24 PF05283.11 EGD93840.1 - 2.2e-05 24.9 0.2 2.2e-05 24.9 0.2 1.9 2 0 0 2 2 2 1 Multi-glycosylated core protein 24 (MGC-24), sialomucin Podoplanin PF05808.11 EGD93840.1 - 0.00032 20.8 0.3 0.00073 19.7 0.0 1.6 2 0 0 2 2 2 1 Podoplanin AJAP1_PANP_C PF15298.6 EGD93840.1 - 0.11 12.7 0.2 0.11 12.7 0.2 1.4 2 0 0 2 2 2 0 AJAP1/PANP C-terminus Syndecan PF01034.20 EGD93840.1 - 0.19 11.6 1.0 0.35 10.8 1.0 1.3 1 0 0 1 1 1 0 Syndecan domain VSP PF03302.13 EGD93840.1 - 0.2 10.5 0.5 0.33 9.8 0.5 1.3 1 0 0 1 1 1 0 Giardia variant-specific surface protein DUF4690 PF15756.5 EGD93840.1 - 0.38 11.4 5.1 0.14 12.7 1.0 2.3 2 0 0 2 2 2 0 Small Novel Rich in Cartilage SKG6 PF08693.10 EGD93840.1 - 0.44 10.0 3.9 1.2 8.6 3.9 1.7 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Pex14_N PF04695.13 EGD93840.1 - 1 10.0 6.6 0.27 11.9 0.3 2.1 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF4124 PF13511.6 EGD93840.1 - 1.1 9.6 0.0 1.1 9.6 0.0 4.2 4 0 0 4 4 4 0 Domain of unknown function (DUF4124) Aldedh PF00171.22 EGD93841.1 - 5.7e-126 420.7 0.0 8.4e-95 318.0 0.0 2.0 1 1 1 2 2 2 2 Aldehyde dehydrogenase family DUF1712 PF08217.11 EGD93842.1 - 9.6e-19 67.3 0.0 3.1e-18 65.6 0.0 1.9 2 0 0 2 2 2 1 Fungal domain of unknown function (DUF1712) Formyl_trans_N PF00551.19 EGD93843.1 - 9.8e-23 80.8 0.0 1.5e-22 80.2 0.0 1.2 1 0 0 1 1 1 1 Formyl transferase adh_short_C2 PF13561.6 EGD93844.1 - 8.5e-43 146.6 0.2 1.1e-42 146.3 0.2 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EGD93844.1 - 4.7e-42 143.7 0.1 6e-42 143.3 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EGD93844.1 - 1.4e-11 44.6 0.4 2e-11 44.1 0.4 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EGD93844.1 - 0.011 15.2 0.2 0.065 12.7 0.2 2.1 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 EGD93844.1 - 0.039 13.1 0.0 0.15 11.1 0.0 1.8 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein EMP24_GP25L PF01105.24 EGD93845.1 - 4.7e-51 173.3 0.0 6.1e-51 172.9 0.0 1.2 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Peptidase_S46 PF10459.9 EGD93845.1 - 0.061 12.0 0.7 0.13 10.9 0.2 1.6 1 1 1 2 2 2 0 Peptidase S46 TMEMspv1-c74-12 PF11044.8 EGD93845.1 - 0.11 12.5 0.2 0.21 11.6 0.2 1.5 1 0 0 1 1 1 0 Plectrovirus spv1-c74 ORF 12 transmembrane protein PspB PF06667.12 EGD93845.1 - 0.2 11.7 0.5 0.42 10.7 0.5 1.6 1 0 0 1 1 1 0 Phage shock protein B SANT_DAMP1_like PF16282.5 EGD93846.1 - 1e-30 105.8 1.3 2e-30 104.8 1.3 1.5 1 0 0 1 1 1 1 SANT/Myb-like domain of DAMP1 DMAP1 PF05499.12 EGD93846.1 - 0.0006 19.7 4.6 0.0006 19.7 4.6 3.0 2 1 1 3 3 3 1 DNA methyltransferase 1-associated protein 1 (DMAP1) Myb_DNA-binding PF00249.31 EGD93846.1 - 0.11 12.8 0.0 0.55 10.5 0.0 2.3 2 1 0 2 2 2 0 Myb-like DNA-binding domain UPF0242 PF06785.11 EGD93846.1 - 0.93 9.6 10.0 0.4 10.8 1.7 2.4 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Meth_synt_2 PF01717.18 EGD93848.1 - 1e-151 504.8 0.0 2.1e-148 493.9 0.0 2.5 3 0 0 3 3 3 2 Cobalamin-independent synthase, Catalytic domain Meth_synt_1 PF08267.12 EGD93848.1 - 9.7e-118 393.2 0.0 5.6e-112 374.3 0.0 2.7 3 0 0 3 3 3 2 Cobalamin-independent synthase, N-terminal domain URO-D PF01208.17 EGD93848.1 - 1.5e-05 24.3 0.0 0.013 14.7 0.0 2.5 2 0 0 2 2 2 2 Uroporphyrinogen decarboxylase (URO-D) VbhA PF18495.1 EGD93848.1 - 0.0053 16.6 0.1 2.2 8.2 0.0 2.8 2 0 0 2 2 2 2 Antitoxin VbhA SHOCT PF09851.9 EGD93848.1 - 0.64 9.8 2.9 0.53 10.1 0.2 2.4 2 0 0 2 2 2 0 Short C-terminal domain Steroid_dh PF02544.16 EGD93849.1 - 7.2e-09 35.8 2.9 0.0056 16.7 0.1 4.0 3 1 0 3 3 3 2 3-oxo-5-alpha-steroid 4-dehydrogenase DUF1295 PF06966.12 EGD93849.1 - 0.015 14.9 0.3 0.1 12.1 0.3 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF1295) Ufd2P_core PF10408.9 EGD93850.1 - 3.2e-207 690.0 14.8 3.9e-207 689.7 14.8 1.1 1 0 0 1 1 1 1 Ubiquitin elongating factor core U-box PF04564.15 EGD93850.1 - 1.2e-27 95.8 1.9 6e-27 93.6 0.5 2.6 2 0 0 2 2 2 1 U-box domain DUF1977 PF09320.11 EGD93852.1 - 1.4e-31 108.8 0.1 2.6e-31 108.0 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1977) DnaJ PF00226.31 EGD93852.1 - 1.5e-22 79.5 0.4 2.6e-22 78.7 0.4 1.4 1 0 0 1 1 1 1 DnaJ domain Aim19 PF10315.9 EGD93853.1 - 9.1e-06 26.0 1.0 2.1e-05 24.8 0.1 1.7 1 1 1 2 2 2 1 Altered inheritance of mitochondria protein 19 CTP_transf_like PF01467.26 EGD93854.1 - 0.00055 20.2 0.1 0.0015 18.8 0.1 1.9 1 1 0 1 1 1 1 Cytidylyltransferase-like Ydc2-catalyt PF09159.10 EGD93856.1 - 2.6e-94 316.1 0.0 3.2e-94 315.8 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial resolvase Ydc2 / RNA splicing MRS1 SAP PF02037.27 EGD93856.1 - 6.2e-05 22.6 0.6 0.00015 21.4 0.6 1.7 1 0 0 1 1 1 1 SAP domain Pox_A22 PF04848.13 EGD93856.1 - 7.1e-05 23.0 0.0 2.1 8.4 0.0 3.4 3 0 0 3 3 3 2 Poxvirus A22 protein Tcp11 PF05794.13 EGD93857.1 - 4.4e-95 319.4 0.0 6.5e-95 318.8 0.0 1.2 1 0 0 1 1 1 1 T-complex protein 11 LIN37 PF15306.6 EGD93857.1 - 2.1 8.6 6.3 1.9 8.7 4.7 1.8 2 1 0 2 2 2 0 LIN37 Peptidase_S10 PF00450.22 EGD93858.1 - 2.8e-76 257.6 0.0 6e-76 256.5 0.0 1.5 1 1 0 1 1 1 1 Serine carboxypeptidase SOG2 PF10428.9 EGD93859.1 - 2.7e-105 353.5 2.4 2.7e-105 353.5 2.4 4.2 3 1 0 3 3 3 1 RAM signalling pathway protein LRR_4 PF12799.7 EGD93859.1 - 5.2e-13 48.9 5.1 5.6e-05 23.4 0.5 3.9 2 1 1 3 3 3 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EGD93859.1 - 1.9e-12 46.7 6.3 2.7e-07 30.2 0.5 2.7 1 1 1 2 2 2 2 Leucine rich repeat LRR_1 PF00560.33 EGD93859.1 - 0.028 14.9 6.7 40 5.3 0.1 5.6 5 0 0 5 5 5 0 Leucine Rich Repeat LRR_6 PF13516.6 EGD93859.1 - 0.058 13.5 5.2 3.3 8.0 0.1 4.1 4 0 0 4 4 4 0 Leucine Rich repeat MRP-S25 PF13741.6 EGD93860.1 - 1.7e-79 266.6 6.0 2.1e-79 266.3 6.0 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal protein S25 MRP-S23 PF10484.9 EGD93860.1 - 0.059 13.6 3.3 3.6 7.9 0.0 2.9 1 1 1 3 3 3 0 Mitochondrial ribosomal protein S23 PPR_2 PF13041.6 EGD93861.1 - 6e-10 39.2 0.3 0.0097 16.1 0.0 4.7 3 1 1 4 4 4 3 PPR repeat family PPR PF01535.20 EGD93861.1 - 3.8e-07 29.9 1.1 0.25 11.7 0.1 4.4 4 0 0 4 4 4 2 PPR repeat PPR_long PF17177.4 EGD93861.1 - 0.0014 18.1 0.0 0.0027 17.1 0.0 1.4 1 0 0 1 1 1 1 Pentacotripeptide-repeat region of PRORP ESSS PF10183.9 EGD93861.1 - 0.035 14.3 0.1 0.087 13.1 0.1 1.6 1 0 0 1 1 1 0 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) PPR_3 PF13812.6 EGD93861.1 - 0.087 12.9 0.2 4.7 7.4 0.0 3.0 3 0 0 3 3 3 0 Pentatricopeptide repeat domain DEAD PF00270.29 EGD93862.1 - 1.1e-16 61.1 0.0 5.1e-16 58.9 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EGD93862.1 - 1.5e-13 51.1 0.0 1.8e-10 41.1 0.0 3.0 3 0 0 3 3 3 2 Helicase conserved C-terminal domain RecQ_Zn_bind PF16124.5 EGD93862.1 - 2.5e-05 24.9 1.9 7.3e-05 23.4 1.9 1.8 1 0 0 1 1 1 1 RecQ zinc-binding KH_1 PF00013.29 EGD93863.1 - 5.6e-08 32.5 0.0 4.2e-06 26.5 0.0 2.5 2 0 0 2 2 2 2 KH domain ATLF PF07737.11 EGD93863.1 - 0.16 11.2 0.0 0.56 9.5 0.0 1.7 2 0 0 2 2 2 0 Anthrax toxin lethal factor, N- and C-terminal domain ALS_ss_C PF10369.9 EGD93864.1 - 2.8e-15 56.3 0.0 6.6e-14 51.9 0.0 2.3 2 0 0 2 2 2 1 Small subunit of acetolactate synthase ACT PF01842.25 EGD93864.1 - 2.1e-12 46.6 0.2 3.7e-12 45.8 0.2 1.4 1 0 0 1 1 1 1 ACT domain ACT_5 PF13710.6 EGD93864.1 - 5e-08 32.7 0.0 9.4e-08 31.8 0.0 1.5 1 0 0 1 1 1 1 ACT domain ACT_6 PF13740.6 EGD93864.1 - 0.03 14.3 0.1 11 6.0 0.0 2.6 2 0 0 2 2 2 0 ACT domain Cu-oxidase_3 PF07732.15 EGD93868.1 - 4.4e-42 142.8 0.1 8.3e-41 138.7 0.2 2.4 2 0 0 2 2 2 1 Multicopper oxidase Cu-oxidase_2 PF07731.14 EGD93868.1 - 2.7e-38 130.8 6.7 3.6e-35 120.7 0.9 3.9 3 1 1 4 4 4 2 Multicopper oxidase Cu-oxidase PF00394.22 EGD93868.1 - 7.3e-26 91.2 0.0 5.2e-25 88.4 0.0 2.2 2 1 0 2 2 2 1 Multicopper oxidase DUF3712 PF12505.8 EGD93869.1 - 3.4e-07 30.6 0.8 0.048 13.9 0.0 3.6 3 0 0 3 3 3 2 Protein of unknown function (DUF3712) OTCace PF00185.24 EGD93870.1 - 9.8e-45 152.4 0.0 1.6e-44 151.8 0.0 1.3 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain OTCace_N PF02729.21 EGD93870.1 - 2.1e-44 151.2 0.1 3e-44 150.6 0.1 1.3 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain DUF3984 PF13136.6 EGD93871.1 - 6.1e-104 348.0 23.0 8.9e-104 347.5 23.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3984) Ndc1_Nup PF09531.10 EGD93872.1 - 7.2e-196 652.5 2.2 8.1e-196 652.4 2.2 1.0 1 0 0 1 1 1 1 Nucleoporin protein Ndc1-Nup Syntaxin_2 PF14523.6 EGD93873.1 - 2.9e-23 82.2 7.5 3.3e-23 81.9 2.2 2.4 2 0 0 2 2 2 1 Syntaxin-like protein SNARE PF05739.19 EGD93873.1 - 9.8e-15 54.3 1.9 9.8e-15 54.3 1.9 2.1 3 0 0 3 3 3 1 SNARE domain Syntaxin PF00804.25 EGD93873.1 - 1.4e-06 28.2 7.9 2.4e-06 27.4 7.9 1.5 1 1 0 1 1 1 1 Syntaxin Synaptobrevin PF00957.21 EGD93873.1 - 0.00024 20.8 0.8 0.0011 18.8 0.3 2.3 2 1 0 2 2 2 1 Synaptobrevin T3SSipB PF16535.5 EGD93873.1 - 0.01 16.3 4.5 0.061 13.8 3.1 2.4 2 0 0 2 2 2 0 Type III cell invasion protein SipB DUF334 PF03904.13 EGD93873.1 - 0.014 15.0 3.5 0.27 10.7 1.5 2.7 1 1 0 2 2 2 0 Domain of unknown function (DUF334) SepF PF04472.12 EGD93873.1 - 0.056 13.7 0.0 0.27 11.5 0.0 2.0 2 0 0 2 2 2 0 Cell division protein SepF DUF883 PF05957.13 EGD93873.1 - 0.092 13.4 9.7 0.57 10.8 0.2 3.2 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF883) Fib_alpha PF08702.10 EGD93873.1 - 0.25 11.5 2.2 1 9.5 0.1 2.5 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family DUF5345 PF17280.2 EGD93873.1 - 0.59 10.2 0.1 0.59 10.2 0.1 2.3 3 0 0 3 3 3 0 Family of unknown function (DUF5345) DUF16 PF01519.16 EGD93873.1 - 0.93 10.0 6.1 0.97 10.0 0.8 2.8 1 1 1 2 2 2 0 Protein of unknown function DUF16 Cyto_heme_lyase PF01265.17 EGD93874.1 - 1.2e-39 136.7 6.1 2.4e-35 122.6 0.2 2.6 2 1 0 2 2 2 2 Cytochrome c/c1 heme lyase MDD_C PF18376.1 EGD93876.1 - 2.1e-56 190.7 0.0 3e-56 190.1 0.0 1.2 1 0 0 1 1 1 1 Mevalonate 5-diphosphate decarboxylase C-terminal domain GHMP_kinases_N PF00288.26 EGD93876.1 - 2.3e-10 40.5 1.7 6.2e-10 39.2 1.7 1.8 1 0 0 1 1 1 1 GHMP kinases N terminal domain IKI3 PF04762.12 EGD93877.1 - 5.5e-293 974.5 0.0 6.5e-293 974.3 0.0 1.0 1 0 0 1 1 1 1 IKI3 family ANAPC4_WD40 PF12894.7 EGD93877.1 - 0.00026 21.2 0.2 2 8.8 0.0 4.3 2 1 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain COX7C PF02935.16 EGD93878.1 - 1.7e-21 76.2 5.3 2.8e-21 75.5 5.3 1.3 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIIc rRNA_proc-arch PF13234.6 EGD93879.1 - 2.8e-92 309.5 1.0 7.1e-92 308.2 1.0 1.7 1 0 0 1 1 1 1 rRNA-processing arch domain DSHCT PF08148.12 EGD93879.1 - 1.3e-54 184.3 1.2 1.3e-54 184.3 1.2 2.1 3 0 0 3 3 3 1 DSHCT (NUC185) domain DEAD PF00270.29 EGD93879.1 - 8.6e-19 68.0 0.1 3.2e-18 66.1 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EGD93879.1 - 3.9e-06 27.2 0.1 2.5e-05 24.6 0.1 2.2 1 1 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EGD93879.1 - 2.3e-05 24.5 0.0 5.8e-05 23.2 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit T2SSE PF00437.20 EGD93879.1 - 0.037 13.1 0.0 0.097 11.7 0.0 1.7 1 0 0 1 1 1 0 Type II/IV secretion system protein ATPase_2 PF01637.18 EGD93879.1 - 0.076 12.9 0.2 0.31 10.9 0.0 2.1 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea DUF5388 PF17363.2 EGD93879.1 - 0.11 12.7 0.6 1.3 9.2 0.0 2.6 2 0 0 2 2 2 0 Family of unknown function (DUF5388) AAA_22 PF13401.6 EGD93879.1 - 0.14 12.5 0.1 0.75 10.1 0.0 2.2 2 0 0 2 2 2 0 AAA domain Cut8 PF08559.10 EGD93880.1 - 1.7e-81 273.4 0.0 2.1e-81 273.1 0.0 1.0 1 0 0 1 1 1 1 Cut8, nuclear proteasome tether protein HalOD1 PF18545.1 EGD93880.1 - 0.1 12.9 0.1 0.21 11.9 0.1 1.4 1 0 0 1 1 1 0 Halobacterial output domain 1 Motile_Sperm PF00635.26 EGD93881.1 - 2.7e-25 88.3 0.1 5.2e-25 87.4 0.1 1.5 1 1 0 1 1 1 1 MSP (Major sperm protein) domain Trypan_PARP PF05887.11 EGD93881.1 - 0.0033 17.4 1.7 0.0058 16.6 1.7 1.4 1 0 0 1 1 1 1 Procyclic acidic repetitive protein (PARP) ASH PF15780.5 EGD93881.1 - 0.013 15.7 0.0 0.032 14.4 0.0 1.6 1 0 0 1 1 1 0 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin UBX PF00789.20 EGD93882.1 - 9.5e-06 25.7 0.1 2.9e-05 24.2 0.0 1.9 2 0 0 2 2 2 1 UBX domain UBA PF00627.31 EGD93882.1 - 0.0019 18.1 0.0 0.0086 16.0 0.0 2.0 2 0 0 2 2 2 1 UBA/TS-N domain Exonuc_VII_L PF02601.15 EGD93882.1 - 0.048 13.2 11.3 0.059 12.9 11.3 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit zf-C2H2_6 PF13912.6 EGD93882.1 - 0.073 13.1 0.2 0.14 12.2 0.2 1.5 1 0 0 1 1 1 0 C2H2-type zinc finger GATA PF00320.27 EGD93882.1 - 0.16 11.6 0.0 0.31 10.7 0.0 1.5 1 0 0 1 1 1 0 GATA zinc finger zf-C2H2 PF00096.26 EGD93882.1 - 0.17 12.4 0.2 0.32 11.5 0.2 1.5 1 0 0 1 1 1 0 Zinc finger, C2H2 type AAA_13 PF13166.6 EGD93882.1 - 2 7.0 22.9 2.9 6.4 22.9 1.2 1 0 0 1 1 1 0 AAA domain zf-C2H2_2 PF12756.7 EGD93882.1 - 2.8 8.3 6.5 0.28 11.5 0.3 2.2 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) FapA PF03961.13 EGD93882.1 - 3.6 6.1 21.1 5 5.6 21.1 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A LMBR1 PF04791.16 EGD93882.1 - 6.6 5.5 13.9 8.1 5.2 13.9 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Rad52_Rad22 PF04098.15 EGD93883.1 - 6.1e-57 191.9 0.0 9.7e-57 191.2 0.0 1.3 1 0 0 1 1 1 1 Rad52/22 family double-strand break repair protein Sperm_Ag_HE2 PF05324.13 EGD93883.1 - 9.3 6.8 7.8 1.6 9.3 2.3 2.4 2 0 0 2 2 2 0 Sperm antigen HE2 UPF0449 PF15136.6 EGD93884.1 - 0.032 14.7 0.3 0.16 12.5 0.3 2.2 1 0 0 1 1 1 0 Uncharacterised protein family UPF0449 Aa_trans PF01490.18 EGD93885.1 - 2.7e-71 240.4 28.7 3.2e-71 240.2 28.7 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein DUF3043 PF11241.8 EGD93885.1 - 0.33 10.9 3.2 30 4.6 0.2 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF3043) Trypsin_2 PF13365.6 EGD93886.1 - 3.8e-06 27.9 0.0 4.1e-05 24.5 0.0 2.6 2 1 0 2 2 2 1 Trypsin-like peptidase domain Peptidase_S32 PF05579.13 EGD93886.1 - 0.00022 20.5 0.0 0.0019 17.4 0.0 2.2 3 0 0 3 3 3 1 Equine arteritis virus serine endopeptidase S32 Peptidase_S64 PF08192.11 EGD93886.1 - 0.00048 18.8 0.0 0.00065 18.3 0.0 1.3 1 0 0 1 1 1 1 Peptidase family S64 Nup54_57_C PF18570.1 EGD93886.1 - 0.13 11.9 0.4 0.25 10.9 0.4 1.4 1 0 0 1 1 1 0 NUP57/Nup54 C-terminal domain SIR4_SID PF16991.5 EGD93887.1 - 0.079 13.0 0.6 0.21 11.6 0.0 1.9 2 0 0 2 2 2 0 Sir4 SID domain Y_phosphatase2 PF03162.13 EGD93888.1 - 2.1e-42 144.5 0.0 3e-42 144.0 0.0 1.1 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.6 EGD93888.1 - 8.3e-09 35.7 0.0 1.2e-08 35.3 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.20 EGD93888.1 - 4.9e-06 26.4 0.0 6.7e-06 25.9 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EGD93888.1 - 0.0011 18.6 0.0 0.0018 17.9 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 EGD93888.1 - 0.1 12.7 0.0 0.17 12.0 0.0 1.4 1 0 0 1 1 1 0 Inositol hexakisphosphate DUF1133 PF06576.11 EGD93888.1 - 0.15 11.5 0.0 0.23 10.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1133) TatD_DNase PF01026.21 EGD93890.1 - 2.5e-47 161.4 0.0 4.5e-47 160.6 0.0 1.3 2 0 0 2 2 2 1 TatD related DNase FMN_dh PF01070.18 EGD93891.1 - 6.2e-112 374.1 0.0 7.5e-112 373.8 0.0 1.1 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Cyt-b5 PF00173.28 EGD93891.1 - 1.7e-17 63.3 0.0 3.4e-17 62.4 0.0 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain ThiG PF05690.14 EGD93891.1 - 0.00081 18.8 0.0 0.034 13.4 0.0 2.2 2 0 0 2 2 2 1 Thiazole biosynthesis protein ThiG NMO PF03060.15 EGD93891.1 - 0.0014 18.1 0.0 0.0025 17.3 0.0 1.4 1 0 0 1 1 1 1 Nitronate monooxygenase Glu_synthase PF01645.17 EGD93891.1 - 0.0014 17.9 0.0 0.0022 17.2 0.0 1.2 1 0 0 1 1 1 1 Conserved region in glutamate synthase IMPDH PF00478.25 EGD93891.1 - 0.02 13.9 0.5 0.054 12.5 0.5 1.7 1 1 0 1 1 1 0 IMP dehydrogenase / GMP reductase domain CbiJ PF02571.14 EGD93891.1 - 0.082 12.4 0.0 4.1 6.8 0.0 2.4 2 0 0 2 2 2 0 Precorrin-6x reductase CbiJ/CobK SAP PF02037.27 EGD93893.1 - 2.2e-09 36.8 0.0 4.5e-09 35.8 0.0 1.6 1 0 0 1 1 1 1 SAP domain HHV-1_VABD PF16852.5 EGD93893.1 - 0.072 13.1 0.2 0.24 11.5 0.2 1.8 1 0 0 1 1 1 0 Herpes viral adaptor-to-host cellular mRNA binding domain PCMT PF01135.19 EGD93893.1 - 0.19 11.5 0.0 0.27 11.0 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) RNA_pol_Rpb1_1 PF04997.12 EGD93894.1 - 3.2e-82 276.4 0.0 5.7e-82 275.5 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_5 PF04998.17 EGD93894.1 - 3.6e-79 265.9 0.9 3.6e-79 265.9 0.9 1.5 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 EGD93894.1 - 8e-72 240.9 0.0 1.5e-71 240.0 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.18 EGD93894.1 - 6.2e-34 117.2 0.0 1.3e-33 116.2 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.17 EGD93894.1 - 1.8e-25 89.0 0.5 5.3e-25 87.4 0.5 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 Asp PF00026.23 EGD93895.1 - 8.3e-71 239.0 1.0 1e-70 238.7 1.0 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EGD93895.1 - 2.9e-10 40.7 0.3 1.2e-07 32.2 0.3 2.6 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 EGD93895.1 - 0.00046 20.8 0.2 0.068 13.8 0.0 2.9 2 2 0 2 2 2 1 Aspartyl protease gag-asp_proteas PF13975.6 EGD93895.1 - 0.011 16.2 0.1 2 9.0 0.0 2.6 2 0 0 2 2 2 0 gag-polyprotein putative aspartyl protease CarboxypepD_reg PF13620.6 EGD93896.1 - 0.014 15.7 1.1 0.17 12.1 0.2 2.3 2 0 0 2 2 2 0 Carboxypeptidase regulatory-like domain Vfa1 PF08432.10 EGD93897.1 - 4.6e-60 203.0 19.3 5.2e-60 202.9 19.3 1.0 1 0 0 1 1 1 1 AAA-ATPase Vps4-associated protein 1 RR_TM4-6 PF06459.12 EGD93897.1 - 0.00042 20.2 13.3 0.00056 19.8 13.3 1.1 1 0 0 1 1 1 1 Ryanodine Receptor TM 4-6 NPR3 PF03666.13 EGD93897.1 - 0.027 13.3 12.9 0.03 13.1 12.9 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF4746 PF15928.5 EGD93897.1 - 0.037 13.5 12.8 0.042 13.3 12.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) SAPS PF04499.15 EGD93897.1 - 0.065 12.0 6.2 0.065 12.0 6.2 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein PPL5 PF18168.1 EGD93897.1 - 0.065 12.5 9.1 0.076 12.3 9.1 1.1 1 0 0 1 1 1 0 Prim-pol family 5 DUF913 PF06025.12 EGD93897.1 - 0.18 10.8 4.3 0.2 10.6 4.3 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF262 PF03235.14 EGD93897.1 - 0.39 10.9 6.8 0.46 10.6 6.8 1.2 1 0 0 1 1 1 0 Protein of unknown function DUF262 DDHD PF02862.17 EGD93897.1 - 0.45 10.6 4.9 0.58 10.3 4.9 1.2 1 0 0 1 1 1 0 DDHD domain Atrophin-1 PF03154.15 EGD93897.1 - 0.71 8.1 19.9 0.95 7.7 19.9 1.2 1 0 0 1 1 1 0 Atrophin-1 family SID-1_RNA_chan PF13965.6 EGD93897.1 - 0.89 7.9 1.9 0.99 7.7 1.9 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 SLC12 PF03522.15 EGD93897.1 - 1.2 8.1 11.6 1.4 7.9 11.6 1.1 1 0 0 1 1 1 0 Solute carrier family 12 DUF4407 PF14362.6 EGD93897.1 - 1.3 8.4 13.7 1.6 8.0 13.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) CDC45 PF02724.14 EGD93897.1 - 2.1 6.5 20.5 2.5 6.3 20.5 1.0 1 0 0 1 1 1 0 CDC45-like protein CLN3 PF02487.17 EGD93897.1 - 2.2 7.2 4.6 2.5 7.1 4.6 1.2 1 0 0 1 1 1 0 CLN3 protein Neur_chan_memb PF02932.16 EGD93897.1 - 2.2 8.3 5.5 2.5 8.1 5.5 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Ycf1 PF05758.12 EGD93897.1 - 2.5 5.8 14.7 2.7 5.7 14.7 1.1 1 0 0 1 1 1 0 Ycf1 Borrelia_P83 PF05262.11 EGD93897.1 - 3 6.2 22.6 3.6 6.0 22.6 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein DUF2722 PF10846.8 EGD93897.1 - 3.3 6.6 15.6 4.4 6.2 15.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) MCM_bind PF09739.9 EGD93897.1 - 3.3 6.0 13.2 4.1 5.7 13.2 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor Presenilin PF01080.17 EGD93897.1 - 4 6.1 13.1 4.6 5.9 13.1 1.1 1 0 0 1 1 1 0 Presenilin RNA_pol_3_Rpc31 PF11705.8 EGD93897.1 - 4.4 7.5 26.6 7.5 6.7 26.6 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 ATP11 PF06644.11 EGD93897.1 - 4.5 7.0 16.9 5.9 6.6 16.9 1.2 1 0 0 1 1 1 0 ATP11 protein ALMT PF11744.8 EGD93897.1 - 4.7 5.9 9.9 5.4 5.7 9.9 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Zip PF02535.22 EGD93897.1 - 5.8 6.0 8.7 6.5 5.9 8.7 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter RasGAP PF00616.19 EGD93897.1 - 7.7 6.2 11.7 10 5.8 11.7 1.3 1 0 0 1 1 1 0 GTPase-activator protein for Ras-like GTPase DSPc PF00782.20 EGD93898.1 - 1.5e-23 83.1 0.0 2e-23 82.7 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Init_tRNA_PT PF04179.12 EGD93898.1 - 0.0066 16.7 0.0 0.013 15.8 0.0 1.4 1 0 0 1 1 1 1 Rit1 DUSP-like domain Y_phosphatase PF00102.27 EGD93898.1 - 0.059 12.9 0.0 0.079 12.5 0.0 1.2 1 0 0 1 1 1 0 Protein-tyrosine phosphatase zf-C2H2 PF00096.26 EGD93899.1 - 0.014 15.8 3.3 0.014 15.8 3.3 4.1 4 0 0 4 4 4 0 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EGD93899.1 - 0.015 15.7 1.2 0.015 15.7 1.2 3.4 4 0 0 4 4 4 0 Zinc-finger double domain zf-C2H2_jaz PF12171.8 EGD93899.1 - 0.066 13.5 4.2 0.19 12.0 4.2 1.8 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding DUF2614 PF11023.8 EGD93899.1 - 0.15 12.2 0.3 0.24 11.5 0.3 1.2 1 0 0 1 1 1 0 Zinc-ribbon containing domain Cytochrome_C7 PF14522.6 EGD93899.1 - 2.2 8.4 13.0 7.5 6.6 13.0 2.0 1 1 0 1 1 1 0 Cytochrome c7 and related cytochrome c zf-C2H2_4 PF13894.6 EGD93899.1 - 2.5 9.2 20.6 0.35 11.8 2.3 4.7 4 0 0 4 4 4 0 C2H2-type zinc finger FA_desaturase PF00487.24 EGD93900.1 - 8.3e-27 94.6 8.6 1.2e-26 94.1 8.6 1.2 1 0 0 1 1 1 1 Fatty acid desaturase Lipid_DES PF08557.10 EGD93900.1 - 2.1e-17 62.3 0.7 3.9e-17 61.4 0.7 1.4 1 0 0 1 1 1 1 Sphingolipid Delta4-desaturase (DES) ABC1 PF03109.16 EGD93901.1 - 5e-33 113.8 0.0 9.2e-33 112.9 0.0 1.5 1 0 0 1 1 1 1 ABC1 family RIO1 PF01163.22 EGD93901.1 - 0.061 12.9 0.0 0.15 11.6 0.0 1.6 2 0 0 2 2 2 0 RIO1 family Anp1 PF03452.14 EGD93902.1 - 4.1e-104 347.7 0.1 5.2e-104 347.3 0.1 1.1 1 0 0 1 1 1 1 Anp1 Recep_L_domain PF01030.24 EGD93903.1 - 2.3e-11 43.8 1.2 0.055 13.6 0.0 5.5 1 1 4 5 5 5 4 Receptor L domain Ecm33 PF12454.8 EGD93903.1 - 7.4e-11 42.0 1.5 1.3e-10 41.2 0.6 2.0 1 1 0 1 1 1 1 GPI-anchored cell wall organization protein LRR_5 PF13306.6 EGD93903.1 - 0.01 15.8 0.8 1.2 9.2 0.1 2.9 1 1 1 2 2 2 0 BspA type Leucine rich repeat region (6 copies) HhH-GPD PF00730.25 EGD93904.1 - 5.3e-13 49.4 0.0 1.2e-12 48.2 0.0 1.6 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HMG14_17 PF01101.18 EGD93904.1 - 0.6 11.1 14.6 1.7 9.7 14.6 1.7 1 0 0 1 1 1 0 HMG14 and HMG17 UCR_14kD PF02271.16 EGD93905.1 - 1.2e-44 150.3 0.2 1.4e-44 150.1 0.2 1.0 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase complex 14kD subunit Mito_carr PF00153.27 EGD93906.1 - 6.1e-63 208.8 2.5 1.9e-21 75.8 0.0 3.7 2 2 1 3 3 3 3 Mitochondrial carrier protein CHD5 PF04420.14 EGD93907.1 - 4e-59 199.0 2.1 5e-59 198.7 2.1 1.1 1 0 0 1 1 1 1 CHD5-like protein HetR_C PF18460.1 EGD93907.1 - 0.02 14.8 0.1 0.033 14.1 0.1 1.3 1 0 0 1 1 1 0 Heterocyst differentiation regulator C-terminal Hood domain SUI1 PF01253.22 EGD93908.1 - 7.8e-19 68.0 0.0 1.9e-18 66.7 0.0 1.7 1 0 0 1 1 1 1 Translation initiation factor SUI1 Pre-PUA PF17832.1 EGD93908.1 - 8.4e-08 32.8 0.1 6.1e-06 26.8 0.1 2.8 1 1 0 1 1 1 1 Pre-PUA-like domain Trypsin PF00089.26 EGD93909.1 - 1.4e-08 34.8 0.1 2.8e-08 33.9 0.1 1.4 1 1 0 1 1 1 1 Trypsin Trypsin_2 PF13365.6 EGD93909.1 - 0.0045 17.9 0.0 0.0067 17.3 0.0 1.3 1 0 0 1 1 1 1 Trypsin-like peptidase domain TIG PF01833.24 EGD93910.1 - 1.5e-09 37.7 0.2 4.5e-09 36.3 0.2 1.8 1 0 0 1 1 1 1 IPT/TIG domain Ank PF00023.30 EGD93910.1 - 1.3e-08 34.9 6.2 0.0025 18.2 2.9 2.7 2 0 0 2 2 2 2 Ankyrin repeat Ank_2 PF12796.7 EGD93910.1 - 6.6e-08 33.0 0.1 1.3e-07 32.1 0.1 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EGD93910.1 - 4.9e-07 29.9 0.9 5.8e-05 23.3 0.6 2.6 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 EGD93910.1 - 5e-07 30.1 0.9 2.1e-06 28.2 0.4 2.2 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EGD93910.1 - 5.5e-06 26.3 0.9 0.078 13.6 0.3 2.7 2 0 0 2 2 2 2 Ankyrin repeat Bap31 PF05529.12 EGD93910.1 - 0.13 12.1 0.0 0.23 11.3 0.0 1.3 1 0 0 1 1 1 0 Bap31/Bap29 transmembrane region TRAPPC10 PF12584.8 EGD93911.1 - 8.8e-40 136.0 0.0 1.8e-39 134.9 0.0 1.6 1 0 0 1 1 1 1 Trafficking protein particle complex subunit 10, TRAPPC10 FA_desaturase PF00487.24 EGD93912.1 - 6.2e-23 81.9 18.3 1.7e-22 80.5 18.3 1.7 1 1 0 1 1 1 1 Fatty acid desaturase DUF3474 PF11960.8 EGD93912.1 - 8.5e-09 35.7 0.0 2e-08 34.5 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3474) Rad51 PF08423.11 EGD93913.1 - 1.2e-39 136.1 0.0 2e-37 128.9 0.0 2.1 2 0 0 2 2 2 2 Rad51 AAA_25 PF13481.6 EGD93913.1 - 1.3e-06 28.2 0.0 2.2e-06 27.4 0.0 1.3 1 0 0 1 1 1 1 AAA domain ATPase PF06745.13 EGD93913.1 - 2.9e-06 26.8 0.0 7.8e-06 25.4 0.0 1.6 1 1 0 1 1 1 1 KaiC DnaB_C PF03796.15 EGD93913.1 - 0.0042 16.5 0.0 0.025 13.9 0.0 1.9 1 1 0 1 1 1 1 DnaB-like helicase C terminal domain DUF1254 PF06863.12 EGD93913.1 - 0.0049 16.9 0.0 1 9.4 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF1254) RecA PF00154.21 EGD93913.1 - 0.031 13.7 0.1 0.11 11.9 0.0 1.8 2 0 0 2 2 2 0 recA bacterial DNA recombination protein AAA_22 PF13401.6 EGD93913.1 - 0.053 13.8 0.0 0.11 12.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 EGD93913.1 - 0.15 11.8 0.0 0.3 10.8 0.0 1.4 1 1 0 1 1 1 0 AAA domain La PF05383.17 EGD93914.1 - 4.5e-21 74.7 0.0 9.3e-21 73.6 0.0 1.6 1 0 0 1 1 1 1 La domain RRM_1 PF00076.22 EGD93914.1 - 2.9e-05 23.8 0.1 8.3e-05 22.3 0.1 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Chitin_synth_2 PF03142.15 EGD93915.1 - 6.2e-22 77.9 2.9 6.2e-22 77.9 2.9 2.8 3 0 0 3 3 3 2 Chitin synthase Glyco_trans_2_3 PF13632.6 EGD93915.1 - 5e-15 55.9 5.8 5e-15 55.9 5.8 2.5 2 2 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 EGD93915.1 - 7.1e-10 39.2 0.1 2.6e-09 37.3 0.1 1.9 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 EGD93915.1 - 0.0095 15.8 0.0 2.8 7.7 0.0 2.4 2 0 0 2 2 2 2 Glycosyl transferase family 2 HSP70 PF00012.20 EGD93916.1 - 9.3e-167 555.8 0.1 1.3e-166 555.4 0.1 1.2 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EGD93916.1 - 4.4e-11 42.2 0.3 9.2e-11 41.1 0.0 1.6 2 0 0 2 2 2 1 MreB/Mbl protein FtsA PF14450.6 EGD93916.1 - 0.0037 17.7 0.1 0.47 10.9 0.0 3.1 2 1 0 2 2 2 1 Cell division protein FtsA Ketoacyl-synt_C PF02801.22 EGD93916.1 - 0.072 13.1 0.0 0.21 11.6 0.0 1.8 1 0 0 1 1 1 0 Beta-ketoacyl synthase, C-terminal domain Thiolase_N PF00108.23 EGD93917.1 - 1.9e-69 233.9 0.2 2.8e-69 233.4 0.2 1.3 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 EGD93917.1 - 3e-41 139.9 0.5 6.2e-41 138.9 0.5 1.5 1 0 0 1 1 1 1 Thiolase, C-terminal domain ACP_syn_III PF08545.10 EGD93917.1 - 0.011 15.5 0.3 2.8 7.9 0.1 2.5 2 0 0 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III ketoacyl-synt PF00109.26 EGD93917.1 - 0.021 14.4 1.2 0.13 11.9 1.2 2.1 2 0 0 2 2 2 0 Beta-ketoacyl synthase, N-terminal domain WLM PF08325.10 EGD93918.1 - 1.5e-49 168.7 0.0 2.1e-49 168.2 0.0 1.2 1 0 0 1 1 1 1 WLM domain DUF45 PF01863.17 EGD93918.1 - 0.00013 22.1 0.1 0.0011 19.0 0.1 2.0 2 0 0 2 2 2 1 Protein of unknown function DUF45 SprT-like PF10263.9 EGD93918.1 - 0.033 14.0 0.2 0.069 13.0 0.0 1.6 2 0 0 2 2 2 0 SprT-like family LicD PF04991.13 EGD93919.1 - 7e-22 78.7 1.1 1.1e-17 65.0 1.9 2.1 1 1 1 2 2 2 2 LicD family HNH_2 PF13391.6 EGD93921.1 - 5.1e-11 42.5 0.0 1.1e-10 41.4 0.0 1.6 1 0 0 1 1 1 1 HNH endonuclease DASH_Ask1 PF08655.10 EGD93922.1 - 1.6e-30 104.8 1.0 2.8e-30 104.0 1.0 1.4 1 0 0 1 1 1 1 DASH complex subunit Ask1 RhoGAP PF00620.27 EGD93923.1 - 5.2e-46 156.2 0.1 1.7e-45 154.6 0.0 1.9 2 0 0 2 2 2 1 RhoGAP domain LIM PF00412.22 EGD93923.1 - 8.3e-14 51.6 18.5 3e-09 37.0 2.7 2.5 2 0 0 2 2 2 2 LIM domain CENP-H PF05837.12 EGD93923.1 - 0.073 13.5 0.2 0.073 13.5 0.2 2.9 2 1 0 2 2 2 0 Centromere protein H (CENP-H) OrfB_Zn_ribbon PF07282.11 EGD93923.1 - 8.9 6.3 16.4 0.19 11.7 0.6 3.6 3 1 1 4 4 4 0 Putative transposase DNA-binding domain TF_Zn_Ribbon PF08271.12 EGD93923.1 - 9 5.9 17.6 33 4.1 0.1 4.4 3 1 0 3 3 3 0 TFIIB zinc-binding 4HBT PF03061.22 EGD93925.1 - 0.014 15.7 0.2 0.034 14.5 0.2 1.7 1 1 0 1 1 1 0 Thioesterase superfamily Neocarzinostat PF00960.18 EGD93925.1 - 0.13 12.3 0.0 1.5 8.8 0.0 2.0 2 0 0 2 2 2 0 Neocarzinostatin family Carn_acyltransf PF00755.20 EGD93926.1 - 2.7e-209 696.6 0.0 3.2e-209 696.4 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase JmjC PF02373.22 EGD93927.1 - 2.4e-38 131.1 1.2 4.2e-38 130.3 0.5 1.9 2 0 0 2 2 2 1 JmjC domain, hydroxylase zf-HC5HC2H PF13771.6 EGD93927.1 - 1e-18 67.3 2.9 2.1e-18 66.4 2.9 1.5 1 0 0 1 1 1 1 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.6 EGD93927.1 - 3.6e-18 65.7 3.0 6.2e-18 65.0 3.0 1.4 1 0 0 1 1 1 1 PHD-zinc-finger like domain JmjN PF02375.17 EGD93927.1 - 4.6e-08 32.9 0.1 1.2e-07 31.6 0.1 1.8 1 0 0 1 1 1 1 jmjN domain UQ_con PF00179.26 EGD93928.1 - 2.2e-24 85.7 0.0 3.9e-24 84.9 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme AA_permease_2 PF13520.6 EGD93929.1 - 5e-61 206.8 47.7 6.8e-61 206.4 47.7 1.2 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EGD93929.1 - 3.5e-29 101.7 44.6 4.6e-29 101.3 44.6 1.1 1 0 0 1 1 1 1 Amino acid permease APH PF01636.23 EGD93930.1 - 7.9e-11 42.3 0.0 4.2e-10 40.0 0.0 1.9 1 1 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EGD93930.1 - 0.0012 18.5 0.0 0.0021 17.7 0.0 1.4 1 0 0 1 1 1 1 Choline/ethanolamine kinase C12orf66_like PF09404.10 EGD93931.1 - 0.025 13.4 0.0 0.029 13.2 0.0 1.0 1 0 0 1 1 1 0 KICSTOR complex C12orf66 like Cyclase PF04199.13 EGD93932.1 - 5.2e-08 33.2 0.0 1.2e-07 32.0 0.0 1.6 1 1 0 1 1 1 1 Putative cyclase PEP_mutase PF13714.6 EGD93933.1 - 2.7e-65 220.2 0.0 3.3e-65 219.9 0.0 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase MinE PF03776.14 EGD93933.1 - 0.097 12.7 0.0 0.19 11.8 0.0 1.4 1 0 0 1 1 1 0 Septum formation topological specificity factor MinE MFS_1 PF07690.16 EGD93934.1 - 7.1e-33 114.0 27.3 1.1e-31 110.1 26.6 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF373 PF04123.13 EGD93934.1 - 1.6 8.1 3.8 0.48 9.8 0.2 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF373) DHDPS PF00701.22 EGD93935.1 - 8.3e-35 119.9 0.0 5.9e-34 117.1 0.0 1.9 1 1 0 1 1 1 1 Dihydrodipicolinate synthetase family zf-HC2 PF13490.6 EGD93935.1 - 0.21 11.9 0.2 0.66 10.3 0.0 1.9 2 0 0 2 2 2 0 Putative zinc-finger Ribonuc_L-PSP PF01042.21 EGD93936.1 - 5.7e-39 132.9 0.1 6.3e-39 132.7 0.1 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP QRPTase_C PF01729.19 EGD93936.1 - 0.01 15.6 0.0 0.012 15.4 0.0 1.1 1 0 0 1 1 1 0 Quinolinate phosphoribosyl transferase, C-terminal domain D-ser_dehydrat PF14031.6 EGD93937.1 - 1.3e-24 86.7 0.0 2.7e-24 85.7 0.0 1.6 1 0 0 1 1 1 1 Putative serine dehydratase domain Ala_racemase_N PF01168.20 EGD93937.1 - 3.4e-10 39.9 0.0 1.5e-09 37.8 0.0 1.9 1 1 0 1 1 1 1 Alanine racemase, N-terminal domain BST2 PF16716.5 EGD93938.1 - 0.38 11.4 3.1 0.18 12.4 0.4 1.9 2 0 0 2 2 2 0 Bone marrow stromal antigen 2 CDC45 PF02724.14 EGD93939.1 - 7.2 4.8 11.6 8 4.6 11.6 1.0 1 0 0 1 1 1 0 CDC45-like protein Velvet PF11754.8 EGD93940.1 - 4.9e-25 88.9 0.1 4.9e-25 88.9 0.1 4.0 2 1 0 2 2 2 1 Velvet factor PPTA PF01239.22 EGD93942.1 - 0.00022 20.8 3.5 0.13 12.0 1.2 2.5 2 0 0 2 2 2 2 Protein prenyltransferase alpha subunit repeat FUSC PF04632.12 EGD93942.1 - 0.25 9.9 4.4 0.36 9.3 4.4 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family AA_permease_2 PF13520.6 EGD93944.1 - 8.5e-49 166.5 49.4 1.1e-48 166.2 49.4 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EGD93944.1 - 4.1e-26 91.6 44.4 2.7e-25 88.9 44.4 1.9 1 1 0 1 1 1 1 Amino acid permease TRAM_LAG1_CLN8 PF03798.16 EGD93945.1 - 1.4e-39 135.9 22.8 1.4e-39 135.9 22.8 1.8 2 0 0 2 2 2 1 TLC domain TRAM1 PF08390.11 EGD93945.1 - 1.9e-13 49.9 2.8 1.9e-13 49.8 0.1 2.3 2 0 0 2 2 2 1 TRAM1-like protein RRM_1 PF00076.22 EGD93946.1 - 5e-15 55.1 0.0 1.4e-14 53.7 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EGD93946.1 - 0.02 15.0 0.0 0.1 12.7 0.0 2.2 1 0 0 1 1 1 0 RNA recognition motif Nup35_RRM_2 PF14605.6 EGD93946.1 - 0.11 12.5 0.0 0.43 10.6 0.0 1.9 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif SMN PF06003.12 EGD93947.1 - 8.8e-09 35.0 1.1 2.1e-07 30.5 0.1 2.1 1 1 1 2 2 2 2 Survival motor neuron protein (SMN) DUF2254 PF10011.9 EGD93947.1 - 0.08 11.8 0.5 0.095 11.5 0.5 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2254) Cytadhesin_P30 PF07271.11 EGD93947.1 - 2.3 7.7 11.3 0.15 11.6 1.6 2.0 1 1 1 2 2 2 0 Cytadhesin P30/P32 Thiolase_N PF00108.23 EGD93948.1 - 2e-14 53.6 0.1 3e-13 49.7 0.1 2.2 1 1 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 EGD93948.1 - 9e-12 44.7 2.9 6.7e-11 41.9 0.0 2.8 2 1 1 3 3 3 1 Thiolase, C-terminal domain ACP_syn_III PF08545.10 EGD93948.1 - 1.3e-07 31.3 0.1 1e-05 25.3 0.1 2.6 2 0 0 2 2 2 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III ketoacyl-synt PF00109.26 EGD93948.1 - 0.003 17.2 0.1 0.0063 16.1 0.1 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain SpoVAD PF07451.11 EGD93948.1 - 0.013 14.2 0.4 0.042 12.6 0.1 1.9 2 0 0 2 2 2 0 Stage V sporulation protein AD (SpoVAD) Mito_carr PF00153.27 EGD93950.1 - 5.9e-40 135.1 5.7 9.6e-16 57.5 0.4 4.1 3 1 0 3 3 3 3 Mitochondrial carrier protein BRO1 PF03097.18 EGD93951.1 - 3.6e-121 404.6 0.2 1.4e-119 399.4 0.0 2.6 3 0 0 3 3 3 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.6 EGD93951.1 - 2.8e-88 296.0 11.0 6.6e-88 294.8 11.0 1.7 1 0 0 1 1 1 1 ALIX V-shaped domain binding to HIV Cellulase-like PF12876.7 EGD93951.1 - 0.0087 15.4 0.5 0.093 12.1 0.1 2.1 2 0 0 2 2 2 1 Sugar-binding cellulase-like GAS PF13851.6 EGD93951.1 - 2.1 7.7 11.3 0.35 10.2 5.0 2.8 3 1 0 3 3 3 0 Growth-arrest specific micro-tubule binding bZIP_2 PF07716.15 EGD93952.1 - 4.2e-13 49.2 12.1 7.2e-13 48.4 12.1 1.4 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.21 EGD93952.1 - 2.1e-05 24.5 10.9 3.6e-05 23.8 10.9 1.4 1 0 0 1 1 1 1 bZIP transcription factor TSC22 PF01166.18 EGD93952.1 - 0.098 13.0 0.5 0.39 11.1 0.5 2.0 1 1 0 1 1 1 0 TSC-22/dip/bun family DUF4094 PF13334.6 EGD93952.1 - 1.3 9.5 5.2 0.27 11.7 1.7 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4094) TFIIA PF03153.13 EGD93952.1 - 1.6 8.7 30.0 2.7 7.9 30.0 1.4 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SOGA PF11365.8 EGD93952.1 - 1.6 9.9 8.5 0.28 12.3 3.7 2.1 2 0 0 2 2 2 0 Protein SOGA CCDC106 PF15794.5 EGD93952.1 - 2.2 8.0 16.9 0.83 9.3 1.6 2.1 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 106 Nucleo_P87 PF07267.11 EGD93952.1 - 9.6 4.9 13.6 13 4.5 13.6 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 CENP-N PF05238.13 EGD93954.1 - 1.3e-120 403.6 4.2 3.1e-120 402.3 4.2 1.5 1 1 0 1 1 1 1 Kinetochore protein CHL4 like zf-RING_2 PF13639.6 EGD93955.1 - 1.6e-05 25.1 2.9 1.6e-05 25.1 2.9 2.2 2 0 0 2 2 2 1 Ring finger domain zf-ANAPC11 PF12861.7 EGD93955.1 - 2.6e-05 24.2 3.0 0.00013 22.0 0.6 2.4 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger FANCL_C PF11793.8 EGD93955.1 - 5.3e-05 23.3 5.0 0.0017 18.5 2.6 2.4 2 0 0 2 2 2 1 FANCL C-terminal domain SWIM PF04434.17 EGD93955.1 - 0.00015 21.3 0.3 0.00029 20.4 0.3 1.5 1 0 0 1 1 1 1 SWIM zinc finger Prok-RING_1 PF14446.6 EGD93955.1 - 0.00069 19.5 1.5 0.0014 18.5 1.5 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 1 PHD PF00628.29 EGD93955.1 - 0.0082 16.0 3.7 0.017 15.0 3.7 1.6 1 0 0 1 1 1 1 PHD-finger zf-rbx1 PF12678.7 EGD93955.1 - 0.012 15.9 1.6 0.012 15.9 1.6 2.1 2 0 0 2 2 2 0 RING-H2 zinc finger domain RINGv PF12906.7 EGD93955.1 - 0.013 15.6 4.6 0.028 14.6 4.6 1.6 1 0 0 1 1 1 0 RING-variant domain zf-RING_4 PF14570.6 EGD93955.1 - 0.17 11.7 3.5 0.38 10.6 3.5 1.7 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING-like PF08746.11 EGD93955.1 - 2.2 8.6 7.5 0.33 11.3 0.8 2.8 4 0 0 4 4 4 0 RING-like domain zf-C3HC4_2 PF13923.6 EGD93955.1 - 4.8 7.1 8.3 0.28 11.1 1.2 2.4 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EGD93955.1 - 8.6 6.5 8.0 0.49 10.5 2.4 1.9 2 0 0 2 2 2 0 RING-type zinc-finger DUF974 PF06159.13 EGD93956.1 - 4.7e-77 259.1 0.0 5.6e-77 258.9 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF974) DENN PF02141.21 EGD93957.1 - 2.5e-55 187.3 0.1 5.3e-55 186.3 0.1 1.6 1 0 0 1 1 1 1 DENN (AEX-3) domain uDENN PF03456.18 EGD93957.1 - 2.8e-15 56.8 0.3 1.4e-14 54.5 0.0 2.4 2 0 0 2 2 2 1 uDENN domain dDENN PF03455.19 EGD93957.1 - 3.2e-14 52.6 0.7 7.3e-14 51.5 0.7 1.7 1 0 0 1 1 1 1 dDENN domain C1_2 PF03107.16 EGD93957.1 - 1.5e-06 28.4 4.6 3.2e-06 27.3 4.6 1.6 1 0 0 1 1 1 1 C1 domain C1_1 PF00130.22 EGD93957.1 - 0.005 16.7 5.8 0.01 15.7 5.8 1.5 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Zf_RING PF16744.5 EGD93957.1 - 0.14 12.3 5.9 0.31 11.2 5.9 1.6 1 0 0 1 1 1 0 KIAA1045 RING finger Zn_ribbon_17 PF17120.5 EGD93957.1 - 2.6 7.8 7.6 4.6 6.9 7.6 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type PHD PF00628.29 EGD93957.1 - 3 7.8 8.7 2.2 8.2 6.6 1.9 1 1 1 2 2 2 0 PHD-finger zf-HIT PF04438.16 EGD93957.1 - 8 6.4 5.5 18 5.3 5.5 1.6 1 1 0 1 1 1 0 HIT zinc finger RTA1 PF04479.13 EGD93958.1 - 7.2e-67 225.0 15.1 7.2e-67 225.0 15.1 1.3 2 0 0 2 2 2 1 RTA1 like protein LHC PF00556.20 EGD93958.1 - 2.4 8.5 8.7 1 9.7 2.0 2.7 2 0 0 2 2 2 0 Antenna complex alpha/beta subunit MBOAT_2 PF13813.6 EGD93961.1 - 9.3e-15 54.7 5.3 9.3e-15 54.7 5.3 1.8 2 0 0 2 2 2 1 Membrane bound O-acyl transferase family Fungal_trans_2 PF11951.8 EGD93962.1 - 0.0012 17.8 0.6 0.0012 17.8 0.6 1.8 2 0 0 2 2 2 1 Fungal specific transcription factor domain SLATT_fungal PF18142.1 EGD93963.1 - 1.9e-33 115.0 0.0 2.6e-33 114.5 0.0 1.2 1 0 0 1 1 1 1 SMODS and SLOG-associating 2TM effector domain Vicilin_N PF04702.12 EGD93963.1 - 0.085 12.7 3.6 0.13 12.1 3.6 1.2 1 0 0 1 1 1 0 Vicilin N terminal region Ninjurin PF04923.12 EGD93963.1 - 0.18 11.8 0.0 0.31 11.0 0.0 1.3 1 0 0 1 1 1 0 Ninjurin HATPase_c_3 PF13589.6 EGD93965.1 - 2.7e-17 62.9 0.0 4.7e-17 62.1 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase MutL_C PF08676.11 EGD93965.1 - 2.8e-10 40.2 0.0 2.1e-09 37.3 0.0 2.1 2 0 0 2 2 2 1 MutL C terminal dimerisation domain HATPase_c PF02518.26 EGD93965.1 - 1.7e-05 25.3 0.1 3.6e-05 24.2 0.1 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase RasGEF PF00617.19 EGD93966.1 - 7.9e-52 176.0 0.7 1.5e-51 175.1 0.7 1.5 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 EGD93966.1 - 2.7e-14 53.3 0.0 8.8e-14 51.6 0.0 1.9 1 0 0 1 1 1 1 RasGEF N-terminal motif SH3_9 PF14604.6 EGD93966.1 - 9.4e-07 28.6 0.0 2.2e-06 27.4 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EGD93966.1 - 3.2e-05 23.5 0.0 7.1e-05 22.3 0.0 1.7 1 0 0 1 1 1 1 SH3 domain DUF2722 PF10846.8 EGD93968.1 - 2.9e-06 26.5 6.9 2.9e-06 26.5 6.9 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) DUF2076 PF09849.9 EGD93968.1 - 0.00041 20.5 10.5 0.00044 20.4 10.5 1.1 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2076) TFIIA PF03153.13 EGD93968.1 - 0.0014 18.7 11.6 0.0014 18.7 11.6 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Med15 PF09606.10 EGD93968.1 - 0.0023 16.7 12.3 0.0023 16.7 12.3 1.0 1 0 0 1 1 1 1 ARC105 or Med15 subunit of Mediator complex non-fungal Gastrin PF00918.17 EGD93968.1 - 0.0047 17.9 2.0 0.0059 17.6 2.0 1.2 1 0 0 1 1 1 1 Gastrin/cholecystokinin family CPSF73-100_C PF11718.8 EGD93968.1 - 0.026 14.1 0.3 0.026 14.1 0.3 1.1 1 0 0 1 1 1 0 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term Pex14_N PF04695.13 EGD93968.1 - 0.032 14.9 6.1 0.042 14.5 6.1 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Spt20 PF12090.8 EGD93968.1 - 0.045 13.4 22.0 0.054 13.1 22.0 1.1 1 0 0 1 1 1 0 Spt20 family Presenilin PF01080.17 EGD93968.1 - 0.071 11.9 0.7 0.065 12.0 0.7 1.1 1 0 0 1 1 1 0 Presenilin DUF3853 PF12964.7 EGD93968.1 - 0.072 13.3 0.5 0.1 12.8 0.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3853) V_ATPase_I PF01496.19 EGD93968.1 - 0.073 11.0 0.5 0.07 11.0 0.5 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family EIIBC-GUT_N PF03612.14 EGD93968.1 - 0.085 12.6 3.4 0.11 12.2 3.4 1.1 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Activator_LAG-3 PF11498.8 EGD93968.1 - 0.1 11.5 23.5 0.12 11.3 23.5 1.1 1 0 0 1 1 1 0 Transcriptional activator LAG-3 DUF3464 PF11947.8 EGD93968.1 - 0.42 10.4 2.5 0.5 10.1 2.5 1.1 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 DUF4407 PF14362.6 EGD93968.1 - 0.46 9.8 9.6 0.6 9.4 9.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF945 PF06097.11 EGD93968.1 - 0.53 9.3 11.3 0.68 9.0 11.3 1.0 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF945) baeRF_family10 PF18854.1 EGD93968.1 - 0.6 10.3 5.4 0.85 9.9 5.4 1.2 1 0 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 10 UPF0560 PF10577.9 EGD93968.1 - 1.4 7.3 9.9 1.5 7.2 9.9 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 YqzE PF14038.6 EGD93968.1 - 2.1 8.4 7.4 14 5.8 7.4 2.0 1 1 0 1 1 1 0 YqzE-like protein DUF4834 PF16118.5 EGD93968.1 - 2.8 9.0 8.2 4.2 8.4 8.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) TERB2 PF15101.6 EGD93968.1 - 6.9 6.7 11.1 9 6.3 11.1 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 WASH-7_C PF14746.6 EGD93968.1 - 7.2 6.3 8.8 9.3 5.9 8.8 1.1 1 0 0 1 1 1 0 WASH complex subunit 7, C-terminal DivIC PF04977.15 EGD93968.1 - 7.5 6.4 15.8 13 5.6 15.8 1.3 1 0 0 1 1 1 0 Septum formation initiator SseC PF04888.12 EGD93968.1 - 9 5.8 14.4 11 5.5 14.4 1.0 1 0 0 1 1 1 0 Secretion system effector C (SseC) like family Roughex PF06020.11 EGD93968.1 - 9.9 5.2 10.7 11 5.0 10.7 1.1 1 0 0 1 1 1 0 Drosophila roughex protein GHMP_kinases_N PF00288.26 EGD93969.1 - 1.9e-11 44.0 0.1 4.4e-11 42.8 0.1 1.7 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 EGD93969.1 - 5.6e-05 23.4 0.0 0.00011 22.4 0.0 1.5 1 0 0 1 1 1 1 GHMP kinases C terminal Med5 PF08689.10 EGD93970.1 - 1e-142 477.2 0.0 2.6e-141 472.6 0.0 2.5 1 1 0 1 1 1 1 Mediator complex subunit Med5 BCDHK_Adom3 PF10436.9 EGD93970.1 - 0.12 12.2 0.3 1.9 8.3 0.1 2.9 3 0 0 3 3 3 0 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase ELFV_dehydrog_N PF02812.18 EGD93975.1 - 7.6e-46 155.2 0.0 3.9e-44 149.7 0.0 2.1 1 1 0 1 1 1 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain DPBB_1 PF03330.18 EGD93976.1 - 0.0019 18.4 0.0 0.0056 16.9 0.0 1.8 1 1 0 1 1 1 1 Lytic transglycolase DUF2749 PF10907.8 EGD93976.1 - 0.16 12.1 0.2 0.36 11.0 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2749) MFS_1 PF07690.16 EGD93977.1 - 6.6e-10 38.4 28.4 6.6e-10 38.4 28.4 4.0 2 2 1 3 3 3 2 Major Facilitator Superfamily Chloroa_b-bind PF00504.21 EGD93977.1 - 1.1 9.7 4.5 0.36 11.3 0.1 2.4 3 0 0 3 3 3 0 Chlorophyll A-B binding protein Ribonuc_red_lgC PF02867.15 EGD93978.1 - 1.1e-186 621.4 0.0 1.6e-186 621.0 0.0 1.2 1 0 0 1 1 1 1 Ribonucleotide reductase, barrel domain Ribonuc_red_lgN PF00317.21 EGD93978.1 - 8.2e-26 89.8 0.0 1.8e-25 88.8 0.0 1.6 1 0 0 1 1 1 1 Ribonucleotide reductase, all-alpha domain ATP-cone PF03477.16 EGD93978.1 - 1.6e-16 60.6 0.1 5.7e-16 58.9 0.0 2.0 2 0 0 2 2 2 1 ATP cone domain PRK PF00485.18 EGD93980.1 - 0.00014 21.7 0.0 0.00019 21.2 0.0 1.2 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family AAA_18 PF13238.6 EGD93980.1 - 0.00048 20.7 0.0 0.021 15.3 0.0 2.1 2 0 0 2 2 2 1 AAA domain NB-ARC PF00931.22 EGD93980.1 - 0.0023 17.2 0.0 0.0034 16.6 0.0 1.1 1 0 0 1 1 1 1 NB-ARC domain AAA_33 PF13671.6 EGD93980.1 - 0.0026 17.9 0.3 0.38 10.9 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 EGD93980.1 - 0.0044 17.4 0.0 0.0068 16.8 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EGD93980.1 - 0.0098 16.3 0.0 0.014 15.8 0.0 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_17 PF13207.6 EGD93980.1 - 0.02 15.3 0.1 1.3 9.4 0.0 2.2 2 0 0 2 2 2 0 AAA domain DUF463 PF04317.12 EGD93980.1 - 0.072 12.0 0.0 0.1 11.5 0.0 1.1 1 0 0 1 1 1 0 YcjX-like family, DUF463 Thymidylate_kin PF02223.17 EGD93980.1 - 0.1 12.3 0.0 4.2 7.0 0.0 2.1 2 0 0 2 2 2 0 Thymidylate kinase MeaB PF03308.16 EGD93980.1 - 0.1 11.5 0.0 0.18 10.8 0.0 1.3 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_19 PF13245.6 EGD93980.1 - 0.12 12.7 0.0 0.12 12.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 EGD93980.1 - 0.15 11.4 0.4 0.35 10.1 0.0 1.7 2 0 0 2 2 2 0 Zeta toxin DUF2075 PF09848.9 EGD93980.1 - 0.16 11.2 0.0 0.22 10.8 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Viral_helicase1 PF01443.18 EGD93980.1 - 0.25 11.1 0.0 0.37 10.5 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase Mur_ligase_M PF08245.12 EGD93982.1 - 1.4e-06 28.4 0.1 3e-06 27.3 0.1 1.6 1 1 0 1 1 1 1 Mur ligase middle domain Mur_ligase_C PF02875.21 EGD93982.1 - 0.057 13.7 0.0 0.15 12.3 0.0 1.7 1 0 0 1 1 1 0 Mur ligase family, glutamate ligase domain Pkinase PF00069.25 EGD93983.1 - 3.3e-71 239.8 0.0 1.1e-70 238.0 0.0 1.8 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD93983.1 - 7.1e-51 173.0 0.0 1.7e-50 171.8 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EGD93983.1 - 0.0037 16.1 0.0 0.0076 15.1 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 EGD93983.1 - 0.14 11.5 0.0 0.76 9.0 0.0 2.1 2 0 0 2 2 2 0 Kinase-like GerD PF17898.1 EGD93983.1 - 0.16 11.9 1.1 0.41 10.6 1.1 1.7 1 0 0 1 1 1 0 Spore germination GerD central core domain Peptidase_M24 PF00557.24 EGD93984.1 - 7e-44 150.0 0.0 8.7e-44 149.7 0.0 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 Pectinesterase PF01095.19 EGD93984.1 - 0.1 11.3 0.0 0.17 10.6 0.0 1.2 1 0 0 1 1 1 0 Pectinesterase RNA_polI_A34 PF08208.11 EGD93984.1 - 0.12 12.5 8.1 0.2 11.7 8.1 1.4 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 Casc1 PF12366.8 EGD93984.1 - 0.2 11.1 1.5 0.35 10.3 1.5 1.3 1 0 0 1 1 1 0 Cancer susceptibility candidate 1 PGA2 PF07543.12 EGD93984.1 - 0.41 10.6 7.5 0.93 9.5 7.5 1.5 1 0 0 1 1 1 0 Protein trafficking PGA2 CDC45 PF02724.14 EGD93984.1 - 0.55 8.5 6.1 0.76 8.0 6.1 1.1 1 0 0 1 1 1 0 CDC45-like protein PBP1_TM PF14812.6 EGD93984.1 - 1.4 9.4 6.4 2.9 8.3 6.4 1.5 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DnaJ PF00226.31 EGD93985.1 - 1.5e-23 82.6 0.3 2.8e-23 81.8 0.3 1.4 1 0 0 1 1 1 1 DnaJ domain Porin_3 PF01459.22 EGD93986.1 - 2.9e-57 194.2 7.4 3.7e-56 190.5 5.4 2.3 2 1 0 2 2 2 1 Eukaryotic porin Asn_synthase PF00733.21 EGD93987.1 - 1.1e-88 298.3 0.1 2.4e-52 178.7 0.0 2.1 1 1 1 2 2 2 2 Asparagine synthase GATase_7 PF13537.6 EGD93987.1 - 3.1e-36 124.0 0.0 5.7e-36 123.1 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.6 EGD93987.1 - 2.2e-26 92.6 0.0 3.8e-26 91.9 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain DUF3700 PF12481.8 EGD93987.1 - 1.1e-06 28.3 0.0 2.1e-06 27.4 0.0 1.3 1 0 0 1 1 1 1 Aluminium induced protein NAD_synthase PF02540.17 EGD93987.1 - 0.0013 17.9 0.1 0.0074 15.4 0.1 1.9 1 1 0 1 1 1 1 NAD synthase UQ_con PF00179.26 EGD93988.1 - 8.9e-47 158.3 0.0 1e-46 158.1 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EGD93988.1 - 1.3e-05 24.9 0.0 1.5e-05 24.7 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 EGD93988.1 - 0.21 11.9 0.9 0.43 10.9 0.8 1.6 1 1 0 1 1 1 0 RWD domain G-patch PF01585.23 EGD93989.1 - 6.6e-12 45.1 1.2 1.3e-11 44.2 1.2 1.4 1 0 0 1 1 1 1 G-patch domain RRM_1 PF00076.22 EGD93989.1 - 0.00015 21.5 0.0 0.00034 20.4 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Mac PF12464.8 EGD93989.1 - 0.11 12.7 1.7 0.26 11.6 0.7 2.1 2 0 0 2 2 2 0 Maltose acetyltransferase AMP-binding PF00501.28 EGD93990.1 - 2.4e-88 296.6 0.0 2.8e-88 296.3 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EGD93990.1 - 1.3e-12 48.5 0.1 2.9e-12 47.4 0.1 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain GH3 PF03321.13 EGD93990.1 - 1.9e-05 23.8 0.0 0.00034 19.6 0.0 2.1 2 0 0 2 2 2 1 GH3 auxin-responsive promoter RTX_C PF08339.10 EGD93990.1 - 0.019 15.0 0.0 0.042 13.9 0.0 1.5 1 0 0 1 1 1 0 RTX C-terminal domain YCII PF03795.14 EGD93991.1 - 2.9e-05 24.4 0.0 3.8e-05 24.0 0.0 1.2 1 0 0 1 1 1 1 YCII-related domain Fungal_trans PF04082.18 EGD93992.1 - 1.6e-14 53.6 1.1 1.4e-13 50.5 1.1 2.4 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EGD93992.1 - 1.2e-06 28.5 13.8 2.2e-06 27.7 13.8 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 EGD93993.1 - 2e-11 43.3 0.0 1.8e-10 40.2 0.0 2.0 2 0 0 2 2 2 1 Fungal specific transcription factor domain Rad10 PF03834.14 EGD93994.1 - 9.2e-49 164.2 0.0 1.3e-48 163.8 0.0 1.2 1 0 0 1 1 1 1 Binding domain of DNA repair protein Ercc1 (rad10/Swi10) HHH_5 PF14520.6 EGD93994.1 - 0.0041 17.7 0.0 0.0084 16.7 0.0 1.5 1 0 0 1 1 1 1 Helix-hairpin-helix domain Tape_meas_lam_C PF09718.10 EGD93994.1 - 0.005 16.9 1.1 0.51 10.5 0.0 2.6 3 0 0 3 3 3 2 Lambda phage tail tape-measure protein (Tape_meas_lam_C) HHH_2 PF12826.7 EGD93994.1 - 0.035 14.2 0.0 0.076 13.1 0.0 1.5 1 0 0 1 1 1 0 Helix-hairpin-helix motif HHH PF00633.23 EGD93994.1 - 0.04 13.8 0.0 0.095 12.6 0.0 1.6 1 0 0 1 1 1 0 Helix-hairpin-helix motif RRM_1 PF00076.22 EGD93995.1 - 9.6e-60 198.3 0.0 1.7e-18 66.2 0.0 5.6 5 0 0 5 5 5 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PHM7_cyt PF14703.6 EGD93995.1 - 2.4e-06 27.9 7.0 2.5 8.3 0.0 5.8 5 3 3 8 8 8 3 Cytosolic domain of 10TM putative phosphate transporter RRM_Rrp7 PF17799.1 EGD93995.1 - 0.00014 21.7 0.6 2.5 7.9 0.0 3.6 2 2 1 3 3 3 2 Rrp7 RRM-like N-terminal domain RRM_7 PF16367.5 EGD93995.1 - 0.00027 21.0 0.0 4.1 7.6 0.0 3.9 3 0 0 3 3 3 1 RNA recognition motif RRM_5 PF13893.6 EGD93995.1 - 0.003 17.1 0.0 1.6 8.4 0.0 2.5 1 1 1 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 EGD93995.1 - 0.012 15.6 2.0 0.78 9.9 0.1 4.4 4 1 0 4 4 4 0 Limkain b1 NosL PF05573.12 EGD93995.1 - 0.049 14.0 0.1 3.2 8.1 0.0 2.4 2 0 0 2 2 2 0 NosL Cyt-b5 PF00173.28 EGD93996.1 - 2.4e-08 34.0 0.0 2.8e-08 33.8 0.0 1.1 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Gryzun PF07919.12 EGD93997.1 - 2e-215 717.0 0.0 2.6e-215 716.7 0.0 1.1 1 0 0 1 1 1 1 Gryzun, putative trafficking through Golgi Foie-gras_1 PF11817.8 EGD93997.1 - 4.8e-85 285.3 2.5 2e-75 253.7 2.4 2.3 2 0 0 2 2 2 2 Foie gras liver health family 1 Gryzun-like PF12742.7 EGD93997.1 - 0.0015 18.5 0.0 0.0036 17.3 0.0 1.7 1 0 0 1 1 1 1 Gryzun, putative Golgi trafficking PhoD PF09423.10 EGD93998.1 - 3.5e-07 29.6 0.1 0.00057 19.0 0.1 2.7 2 1 0 2 2 2 2 PhoD-like phosphatase DUF3220 PF11516.8 EGD93998.1 - 0.12 12.5 0.0 0.42 10.8 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3120) Rhomboid PF01694.22 EGD93999.1 - 9.6e-23 80.8 8.6 2.5e-22 79.5 6.7 2.0 2 0 0 2 2 2 1 Rhomboid family SlyX PF04102.12 EGD94000.1 - 0.022 15.4 0.8 1.8 9.2 0.3 2.3 2 0 0 2 2 2 0 SlyX Spc7 PF08317.11 EGD94000.1 - 0.1 11.5 0.0 0.13 11.1 0.0 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein NIF PF03031.18 EGD94001.1 - 2.8e-44 150.6 0.0 5e-36 123.8 0.0 2.3 1 1 1 2 2 2 2 NLI interacting factor-like phosphatase Aminotran_5 PF00266.19 EGD94002.1 - 3.7e-28 98.5 0.0 4.8e-28 98.2 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.21 EGD94002.1 - 0.0056 15.9 0.0 0.0065 15.7 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II KR PF08659.10 EGD94002.1 - 0.1 12.5 0.0 0.21 11.5 0.0 1.5 1 0 0 1 1 1 0 KR domain RSS_P20 PF11757.8 EGD94003.1 - 0.013 16.0 0.1 0.22 12.0 0.1 2.3 2 0 0 2 2 2 0 Suppressor of RNA silencing P21-like N-terminal domain DASH_Dad3 PF08656.10 EGD94003.1 - 0.077 13.1 0.1 0.14 12.3 0.1 1.4 1 0 0 1 1 1 0 DASH complex subunit Dad3 HsbA PF12296.8 EGD94003.1 - 0.084 13.3 0.0 0.17 12.3 0.0 1.4 1 0 0 1 1 1 0 Hydrophobic surface binding protein A DUF2203 PF09969.9 EGD94003.1 - 0.089 13.5 0.9 0.4 11.4 0.1 2.3 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2203) HECT PF00632.25 EGD94004.1 - 3.3e-98 328.9 0.0 4.6e-98 328.5 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) WW PF00397.26 EGD94004.1 - 4.8e-33 112.9 31.6 9.7e-13 48.0 5.7 4.7 5 0 0 5 5 5 3 WW domain C2 PF00168.30 EGD94004.1 - 8.5e-20 71.0 0.0 2.2e-19 69.6 0.0 1.7 1 0 0 1 1 1 1 C2 domain RRM_1 PF00076.22 EGD94005.1 - 2.3e-15 56.2 0.0 3.6e-15 55.5 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Med9 PF07544.13 EGD94005.1 - 0.0069 16.4 0.7 0.012 15.7 0.7 1.3 1 0 0 1 1 1 1 RNA polymerase II transcription mediator complex subunit 9 Spc7 PF08317.11 EGD94005.1 - 0.013 14.4 1.8 0.015 14.2 1.8 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein EMP24_GP25L PF01105.24 EGD94005.1 - 0.034 14.1 0.8 0.049 13.6 0.8 1.1 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD Nup35_RRM_2 PF14605.6 EGD94005.1 - 0.05 13.6 0.0 0.088 12.8 0.0 1.4 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif Nup54 PF13874.6 EGD94005.1 - 0.064 13.4 0.6 0.084 13.0 0.6 1.2 1 0 0 1 1 1 0 Nucleoporin complex subunit 54 V_ATPase_I PF01496.19 EGD94005.1 - 0.18 9.7 0.8 0.2 9.5 0.8 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family UPF0242 PF06785.11 EGD94005.1 - 0.28 11.3 2.2 0.34 11.0 2.2 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DivIC PF04977.15 EGD94005.1 - 1.6 8.5 4.5 2.6 7.9 4.5 1.3 1 0 0 1 1 1 0 Septum formation initiator SUZ PF12752.7 EGD94006.1 - 2.7e-14 53.7 12.6 2.7e-14 53.7 12.6 4.9 4 1 0 4 4 4 1 SUZ domain R3H PF01424.22 EGD94006.1 - 4.1e-08 33.1 0.0 8.7e-08 32.0 0.0 1.6 1 0 0 1 1 1 1 R3H domain zf-CCHC_3 PF13917.6 EGD94007.1 - 2.4e-05 24.2 2.4 2.4e-05 24.2 2.4 2.7 2 1 0 2 2 2 1 Zinc knuckle cwf18 PF08315.12 EGD94008.1 - 3.4e-41 141.1 8.9 5.3e-41 140.4 8.9 1.2 1 0 0 1 1 1 1 cwf18 pre-mRNA splicing factor PPR_2 PF13041.6 EGD94009.1 - 7.4e-23 80.5 0.6 3.4e-10 39.9 0.0 5.2 4 1 1 5 5 5 3 PPR repeat family PPR PF01535.20 EGD94009.1 - 3.3e-14 52.1 0.0 0.00046 20.2 0.0 5.0 5 0 0 5 5 5 3 PPR repeat PPR_3 PF13812.6 EGD94009.1 - 7e-09 35.6 0.1 0.0016 18.4 0.0 3.3 2 1 1 3 3 3 3 Pentatricopeptide repeat domain PPR_1 PF12854.7 EGD94009.1 - 1.1e-08 34.6 0.0 0.0013 18.4 0.0 4.1 4 0 0 4 4 4 2 PPR repeat PPR_long PF17177.4 EGD94009.1 - 2.1e-07 30.5 0.0 0.00026 20.4 0.0 2.6 2 0 0 2 2 2 2 Pentacotripeptide-repeat region of PRORP TFIID-18kDa PF02269.16 EGD94010.1 - 2.5e-23 81.9 0.0 3.8e-23 81.3 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor IID, 18kD subunit TFIID_20kDa PF03847.13 EGD94010.1 - 0.011 16.2 0.1 0.021 15.3 0.1 1.4 1 0 0 1 1 1 0 Transcription initiation factor TFIID subunit A Histone PF00125.24 EGD94010.1 - 0.072 13.5 0.1 0.21 12.0 0.0 1.8 2 0 0 2 2 2 0 Core histone H2A/H2B/H3/H4 CENP-S PF15630.6 EGD94010.1 - 0.081 13.3 0.0 0.13 12.6 0.0 1.2 1 0 0 1 1 1 0 CENP-S protein JAB PF01398.21 EGD94011.1 - 5.6e-20 71.5 0.0 9.8e-20 70.7 0.0 1.4 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.6 EGD94011.1 - 1.5e-18 67.3 0.2 2.7e-18 66.4 0.2 1.4 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function UPF0172 PF03665.13 EGD94011.1 - 8.6e-05 22.7 0.0 0.0002 21.5 0.0 1.5 2 0 0 2 2 2 1 Uncharacterised protein family (UPF0172) UTP25 PF06862.12 EGD94012.1 - 1.2e-189 631.1 0.0 1.4e-189 630.8 0.0 1.1 1 0 0 1 1 1 1 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 DEAD PF00270.29 EGD94012.1 - 0.00028 20.7 0.0 0.58 9.9 0.0 2.3 2 0 0 2 2 2 2 DEAD/DEAH box helicase EamA PF00892.20 EGD94013.1 - 6.2e-20 71.8 23.5 1.3e-10 41.6 5.3 2.9 2 1 1 3 3 3 2 EamA-like transporter family Trp_oprn_chp PF09534.10 EGD94013.1 - 0.076 12.8 0.1 3.9 7.2 0.1 2.2 2 0 0 2 2 2 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Serinc PF03348.15 EGD94013.1 - 0.1 11.5 0.1 0.58 9.0 0.0 2.0 2 0 0 2 2 2 0 Serine incorporator (Serinc) PEP-CTERM PF07589.11 EGD94013.1 - 0.17 12.0 10.7 0.84 9.8 0.0 4.1 4 0 0 4 4 4 0 PEP-CTERM motif CTP_transf_like PF01467.26 EGD94014.1 - 9.8e-30 103.6 0.0 1.9e-29 102.7 0.0 1.5 1 0 0 1 1 1 1 Cytidylyltransferase-like HIGH_NTase1 PF05636.11 EGD94014.1 - 0.13 11.4 0.2 0.29 10.3 0.0 1.6 2 0 0 2 2 2 0 HIGH Nucleotidyl Transferase IHABP4_N PF16174.5 EGD94014.1 - 1.1 9.8 12.0 4 8.0 9.7 2.3 2 0 0 2 2 2 0 Intracellular hyaluronan-binding protein 4 N-terminal PP2C PF00481.21 EGD94015.1 - 1.1e-78 264.5 0.1 3.2e-78 262.9 0.1 1.7 1 1 0 1 1 1 1 Protein phosphatase 2C LpxD PF04613.14 EGD94015.1 - 0.11 12.3 0.1 0.95 9.3 0.0 2.3 2 0 0 2 2 2 0 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD CDC45 PF02724.14 EGD94015.1 - 0.14 10.4 2.5 0.2 9.9 2.5 1.1 1 0 0 1 1 1 0 CDC45-like protein Acetyltransf_1 PF00583.25 EGD94016.1 - 9.7e-15 54.8 0.1 1.7e-14 54.0 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EGD94016.1 - 1.2e-12 47.9 0.0 1.8e-12 47.3 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EGD94016.1 - 1.3e-10 41.5 0.0 1.8e-10 41.1 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EGD94016.1 - 2e-08 34.1 0.1 3.4e-08 33.3 0.1 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_8 PF13523.6 EGD94016.1 - 0.00056 19.6 0.1 0.001 18.8 0.1 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EGD94016.1 - 0.0014 18.7 0.0 0.0027 17.8 0.0 1.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 EGD94016.1 - 0.0036 17.4 0.1 0.0072 16.4 0.1 1.5 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase PanZ PF12568.8 EGD94016.1 - 0.049 13.4 0.2 0.08 12.7 0.2 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain, PanZ Acetyltransf_4 PF13420.7 EGD94016.1 - 0.083 13.0 0.0 0.12 12.5 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain MOZART1 PF12554.8 EGD94017.1 - 4.3e-26 90.4 1.5 4.9e-26 90.3 1.5 1.0 1 0 0 1 1 1 1 Mitotic-spindle organizing gamma-tubulin ring associated CUE PF02845.16 EGD94018.1 - 1.3e-11 44.0 0.0 3.1e-11 42.7 0.0 1.7 2 0 0 2 2 2 1 CUE domain eRF1_2 PF03464.15 EGD94018.1 - 0.047 14.0 0.0 0.084 13.2 0.0 1.4 1 0 0 1 1 1 0 eRF1 domain 2 HA2 PF04408.23 EGD94019.1 - 1.9e-17 63.5 0.0 3.9e-17 62.5 0.0 1.6 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 EGD94019.1 - 8.8e-14 51.6 0.0 1.8e-13 50.6 0.0 1.5 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 EGD94019.1 - 4e-12 46.5 0.1 1.8e-11 44.4 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 EGD94019.1 - 2.6e-05 24.1 0.1 6.9e-05 22.7 0.1 1.7 1 1 0 1 1 1 1 DEAD/DEAH box helicase AAA_30 PF13604.6 EGD94019.1 - 0.00032 20.5 0.0 0.00069 19.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EGD94019.1 - 0.00034 20.9 0.1 0.0019 18.5 0.1 2.1 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EGD94019.1 - 0.0015 18.9 0.2 0.0038 17.6 0.0 1.7 2 0 0 2 2 2 1 AAA domain cobW PF02492.19 EGD94019.1 - 0.0059 16.2 0.1 0.24 11.0 0.0 2.3 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain T2SSE PF00437.20 EGD94019.1 - 0.03 13.4 0.1 0.1 11.7 0.0 1.9 2 0 0 2 2 2 0 Type II/IV secretion system protein ABC_tran PF00005.27 EGD94019.1 - 0.059 13.9 0.0 0.19 12.3 0.0 2.0 2 0 0 2 2 2 0 ABC transporter PITH PF06201.13 EGD94020.1 - 5.1e-43 146.9 0.0 6.2e-43 146.6 0.0 1.1 1 0 0 1 1 1 1 PITH domain Snf7 PF03357.21 EGD94021.1 - 9.4e-30 103.5 9.8 1.2e-29 103.2 9.8 1.1 1 0 0 1 1 1 1 Snf7 DHDPS PF00701.22 EGD94021.1 - 0.013 14.3 0.3 0.026 13.3 0.2 1.4 1 1 0 1 1 1 0 Dihydrodipicolinate synthetase family AAA PF00004.29 EGD94022.1 - 4.1e-91 302.3 0.0 1.3e-45 155.1 0.0 2.8 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EGD94022.1 - 2.5e-18 65.6 2.0 9.9e-09 34.9 0.1 2.8 2 0 0 2 2 2 2 AAA+ lid domain AAA_16 PF13191.6 EGD94022.1 - 3.2e-14 53.7 1.0 0.00019 21.9 0.0 4.7 4 2 1 5 5 4 2 AAA ATPase domain RuvB_N PF05496.12 EGD94022.1 - 2.9e-13 49.9 0.0 5.4e-06 26.2 0.0 2.6 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EGD94022.1 - 1.7e-11 44.5 0.8 0.0075 16.5 0.0 5.3 3 2 2 5 5 4 2 AAA domain AAA_2 PF07724.14 EGD94022.1 - 9.3e-11 42.1 0.0 0.00031 20.9 0.0 2.5 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_33 PF13671.6 EGD94022.1 - 1e-10 41.9 0.0 3.3e-05 24.1 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_5 PF07728.14 EGD94022.1 - 4.9e-10 39.5 0.3 0.00086 19.3 0.0 4.0 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) TIP49 PF06068.13 EGD94022.1 - 4.9e-09 35.9 0.0 0.00015 21.1 0.0 2.3 2 0 0 2 2 2 2 TIP49 P-loop domain RNA_helicase PF00910.22 EGD94022.1 - 6.4e-08 33.0 0.0 0.0064 16.9 0.0 2.8 2 1 0 2 2 2 2 RNA helicase AAA_14 PF13173.6 EGD94022.1 - 1.6e-07 31.5 0.0 0.015 15.3 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.6 EGD94022.1 - 3.4e-07 30.9 0.0 0.012 16.1 0.0 2.9 3 0 0 3 3 2 2 AAA domain AAA_28 PF13521.6 EGD94022.1 - 5.3e-07 30.0 0.0 0.0074 16.5 0.0 2.5 2 0 0 2 2 2 2 AAA domain Mg_chelatase PF01078.21 EGD94022.1 - 7.5e-07 28.7 1.9 0.022 14.1 0.1 2.8 3 0 0 3 3 2 2 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 EGD94022.1 - 8.3e-07 28.9 0.1 0.059 13.1 0.0 2.6 2 1 0 2 2 2 2 IstB-like ATP binding protein Zeta_toxin PF06414.12 EGD94022.1 - 9.8e-07 28.2 0.0 0.033 13.5 0.0 2.5 2 0 0 2 2 2 2 Zeta toxin AAA_3 PF07726.11 EGD94022.1 - 1.2e-06 28.4 0.0 0.004 17.0 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 EGD94022.1 - 9e-06 25.7 0.0 0.14 12.1 0.0 3.4 3 0 0 3 3 3 2 NACHT domain TsaE PF02367.17 EGD94022.1 - 1e-05 25.5 0.0 0.078 13.0 0.0 2.3 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE Rad17 PF03215.15 EGD94022.1 - 1.6e-05 24.9 0.0 0.086 12.8 0.0 2.3 2 0 0 2 2 2 2 Rad17 P-loop domain AAA_7 PF12775.7 EGD94022.1 - 3.9e-05 23.2 0.0 0.13 11.8 0.0 2.6 2 1 0 2 2 2 2 P-loop containing dynein motor region ABC_tran PF00005.27 EGD94022.1 - 4.9e-05 23.9 0.0 0.18 12.3 0.0 2.7 2 0 0 2 2 2 2 ABC transporter Cytidylate_kin2 PF13189.6 EGD94022.1 - 5.3e-05 23.4 0.0 0.017 15.3 0.0 2.4 2 0 0 2 2 2 1 Cytidylate kinase-like family AAA_17 PF13207.6 EGD94022.1 - 6.6e-05 23.4 0.0 0.19 12.2 0.0 3.3 2 1 0 2 2 2 1 AAA domain AAA_25 PF13481.6 EGD94022.1 - 7.1e-05 22.5 0.6 1.2 8.6 0.0 3.9 3 1 1 4 4 4 2 AAA domain ATPase PF06745.13 EGD94022.1 - 8e-05 22.1 0.1 0.68 9.2 0.0 3.2 2 1 1 3 3 3 2 KaiC Sigma54_activat PF00158.26 EGD94022.1 - 9.5e-05 22.2 0.0 0.38 10.4 0.0 3.1 2 1 0 2 2 2 2 Sigma-54 interaction domain PhoH PF02562.16 EGD94022.1 - 0.00041 19.9 0.0 0.54 9.7 0.0 2.4 2 0 0 2 2 2 2 PhoH-like protein TniB PF05621.11 EGD94022.1 - 0.00041 19.8 0.0 0.13 11.6 0.0 3.1 3 0 0 3 3 3 1 Bacterial TniB protein AFG1_ATPase PF03969.16 EGD94022.1 - 0.00045 19.2 0.0 0.088 11.7 0.0 2.4 2 0 0 2 2 2 1 AFG1-like ATPase AAA_11 PF13086.6 EGD94022.1 - 0.00048 20.0 0.1 1.2 8.9 0.0 2.6 3 0 0 3 3 2 2 AAA domain NB-ARC PF00931.22 EGD94022.1 - 0.00052 19.3 0.0 0.99 8.5 0.0 3.0 3 0 0 3 3 3 1 NB-ARC domain SKI PF01202.22 EGD94022.1 - 0.00071 19.7 0.0 0.8 9.8 0.0 2.8 2 0 0 2 2 2 1 Shikimate kinase Viral_helicase1 PF01443.18 EGD94022.1 - 0.00089 19.1 0.0 0.6 9.8 0.0 2.3 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase ATPase_2 PF01637.18 EGD94022.1 - 0.00096 19.1 0.0 1.8 8.4 0.0 3.3 2 1 1 3 3 3 1 ATPase domain predominantly from Archaea AAA_24 PF13479.6 EGD94022.1 - 0.001 18.8 0.0 0.88 9.3 0.0 2.4 2 0 0 2 2 2 1 AAA domain DUF815 PF05673.13 EGD94022.1 - 0.0012 18.1 0.0 0.049 12.8 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF815) Sigma54_activ_2 PF14532.6 EGD94022.1 - 0.0012 19.0 0.0 2.3 8.3 0.0 2.6 2 0 0 2 2 2 2 Sigma-54 interaction domain Parvo_NS1 PF01057.17 EGD94022.1 - 0.0021 17.2 0.0 1.7 7.7 0.0 2.2 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 AAA_19 PF13245.6 EGD94022.1 - 0.012 15.9 1.7 3.5 8.0 0.2 3.1 2 1 0 2 2 2 0 AAA domain CPT PF07931.12 EGD94022.1 - 0.019 14.8 0.0 0.47 10.3 0.0 2.3 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein ResIII PF04851.15 EGD94022.1 - 0.024 14.6 0.0 8.7 6.3 0.0 2.8 2 1 1 3 3 2 0 Type III restriction enzyme, res subunit Vps4_C PF09336.10 EGD94022.1 - 0.053 13.5 0.4 1.8 8.6 0.1 3.2 2 1 1 3 3 3 0 Vps4 C terminal oligomerisation domain IPT PF01745.16 EGD94022.1 - 0.057 12.8 0.1 7.6 5.8 0.0 2.6 3 0 0 3 3 2 0 Isopentenyl transferase AAA_23 PF13476.6 EGD94022.1 - 0.065 13.7 0.9 5.6 7.4 0.0 3.2 3 0 0 3 3 3 0 AAA domain DUF2075 PF09848.9 EGD94022.1 - 0.078 12.2 0.0 4.7 6.3 0.0 2.2 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) NTPase_1 PF03266.15 EGD94022.1 - 0.11 12.4 0.0 11 5.9 0.0 2.6 2 0 0 2 2 2 0 NTPase AAA_30 PF13604.6 EGD94022.1 - 0.13 11.9 0.3 17 5.0 0.0 2.6 3 0 0 3 3 2 0 AAA domain Cytidylate_kin PF02224.18 EGD94022.1 - 0.16 11.7 0.1 13 5.5 0.0 2.6 2 0 0 2 2 2 0 Cytidylate kinase BET PF17035.5 EGD94022.1 - 2.4 8.4 4.1 5.5 7.2 0.5 3.2 4 0 0 4 4 3 0 Bromodomain extra-terminal - transcription regulation BOP1NT PF08145.12 EGD94023.1 - 3.1e-105 351.8 6.9 5.2e-105 351.1 6.9 1.4 1 0 0 1 1 1 1 BOP1NT (NUC169) domain WD40 PF00400.32 EGD94023.1 - 8.3e-21 73.9 8.4 1.1e-09 38.7 0.2 5.3 5 0 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EGD94023.1 - 5.7e-05 23.3 0.0 0.032 14.5 0.0 3.7 3 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain PQQ_3 PF13570.6 EGD94023.1 - 0.067 13.7 2.6 16 6.1 0.0 4.2 4 0 0 4 4 4 0 PQQ-like domain Zn_clus PF00172.18 EGD94024.1 - 5e-08 32.9 7.2 9e-08 32.1 7.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Leo1 PF04004.13 EGD94025.1 - 5.3e-29 101.2 0.7 5.3e-29 101.2 0.7 2.4 2 1 0 2 2 2 1 Leo1-like protein Mob1_phocein PF03637.17 EGD94026.1 - 4.5e-52 176.5 0.0 1.1e-51 175.2 0.0 1.6 1 1 0 1 1 1 1 Mob1/phocein family IF-2B PF01008.17 EGD94027.1 - 9.4e-59 198.9 7.0 1.2e-48 165.7 3.4 3.0 2 1 0 2 2 2 2 Initiation factor 2 subunit family Ribosom_S12_S23 PF00164.25 EGD94028.1 - 3.2e-50 168.5 1.0 4e-50 168.2 1.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S12/S23 DUF5315 PF17242.2 EGD94029.1 - 9e-19 67.1 0.0 2.2e-18 65.8 0.0 1.7 1 0 0 1 1 1 1 Disordered region of unknown function (DUF5315) THUMP PF02926.17 EGD94029.1 - 0.013 15.6 0.6 0.019 15.1 0.6 1.2 1 0 0 1 1 1 0 THUMP domain AIM5 PF17050.5 EGD94030.1 - 2.6e-11 44.2 0.2 4.1e-11 43.5 0.2 1.3 1 0 0 1 1 1 1 Altered inheritance of mitochondria 5 Ribosomal_L17 PF01196.19 EGD94031.1 - 3.7e-34 117.5 0.0 8.2e-34 116.4 0.0 1.5 2 0 0 2 2 2 1 Ribosomal protein L17 Mrpl_C PF18502.1 EGD94031.1 - 0.042 14.1 0.1 0.47 10.7 0.0 2.0 2 0 0 2 2 2 0 54S ribosomal protein L8 C-terminal domain Metallophos_2 PF12850.7 EGD94032.1 - 1.5e-12 48.0 0.0 1.8e-12 47.8 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain DUF202 PF02656.15 EGD94035.1 - 3.9e-14 52.8 4.5 3.9e-14 52.8 4.5 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF202) DUF5337 PF17272.2 EGD94035.1 - 1.4 8.8 10.0 0.23 11.3 5.2 2.2 2 1 0 2 2 2 0 Family of unknown function (DUF5337) Tctex-1 PF03645.13 EGD94036.1 - 4e-21 75.2 0.0 6.8e-21 74.4 0.0 1.3 1 0 0 1 1 1 1 Tctex-1 family WD40 PF00400.32 EGD94037.1 - 1.2e-34 117.7 19.3 1.2e-09 38.6 0.2 8.5 8 0 0 8 8 8 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EGD94037.1 - 9.9e-09 35.4 0.8 0.016 15.5 0.0 4.3 2 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EGD94037.1 - 2.4e-06 26.5 3.6 0.052 12.2 0.1 4.4 3 1 1 4 4 4 2 Nucleoporin Nup120/160 PALB2_WD40 PF16756.5 EGD94037.1 - 6.3e-06 25.3 0.6 3.4e-05 23.0 0.1 2.2 2 1 0 2 2 2 1 Partner and localizer of BRCA2 WD40 domain Ge1_WD40 PF16529.5 EGD94037.1 - 0.0011 18.0 0.1 1.7 7.5 0.0 3.8 3 1 1 4 4 4 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Hira PF07569.11 EGD94037.1 - 0.092 12.5 4.1 0.2 11.4 0.4 3.2 2 1 1 3 3 3 0 TUP1-like enhancer of split HPS3_N PF14761.6 EGD94037.1 - 0.19 11.3 0.0 0.92 9.0 0.0 2.1 1 1 1 2 2 2 0 Hermansky-Pudlak syndrome 3 Filament PF00038.21 EGD94038.1 - 0.034 13.7 0.5 0.055 13.0 0.5 1.2 1 0 0 1 1 1 0 Intermediate filament protein HNH_2 PF13391.6 EGD94039.1 - 1.8e-06 27.9 0.0 4.1e-06 26.8 0.0 1.6 1 0 0 1 1 1 1 HNH endonuclease ketoacyl-synt PF00109.26 EGD94040.1 - 1.1e-78 264.4 0.0 1.8e-78 263.6 0.0 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain SAT PF16073.5 EGD94040.1 - 7e-74 248.6 1.6 1e-73 248.0 0.1 2.2 3 0 0 3 3 3 1 Starter unit:ACP transacylase in aflatoxin biosynthesis Acyl_transf_1 PF00698.21 EGD94040.1 - 2.5e-36 125.8 0.0 4.4e-36 125.0 0.0 1.3 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 EGD94040.1 - 1.8e-34 118.3 0.1 4.7e-34 116.9 0.1 1.8 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Thioesterase PF00975.20 EGD94040.1 - 1.4e-27 97.3 0.0 3.7e-27 95.9 0.0 1.8 2 0 0 2 2 2 1 Thioesterase domain PS-DH PF14765.6 EGD94040.1 - 2.1e-17 63.3 0.0 3.5e-17 62.6 0.0 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase PP-binding PF00550.25 EGD94040.1 - 1.5e-13 50.9 7.9 9.6e-07 29.1 0.4 2.8 2 0 0 2 2 2 2 Phosphopantetheine attachment site KAsynt_C_assoc PF16197.5 EGD94040.1 - 5.6e-08 33.2 0.1 1.5e-07 31.8 0.1 1.7 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Abhydrolase_6 PF12697.7 EGD94040.1 - 0.0013 19.4 0.3 0.0084 16.7 0.1 2.5 2 0 0 2 2 2 1 Alpha/beta hydrolase family Thiolase_N PF00108.23 EGD94040.1 - 0.0099 15.3 0.0 0.025 14.0 0.0 1.6 1 0 0 1 1 1 1 Thiolase, N-terminal domain Abhydrolase_3 PF07859.13 EGD94040.1 - 0.026 14.4 0.0 0.21 11.4 0.0 2.5 2 0 0 2 2 2 0 alpha/beta hydrolase fold FMO-like PF00743.19 EGD94041.1 - 3.2e-64 217.2 0.0 4.1e-64 216.9 0.0 1.0 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 EGD94041.1 - 8.4e-13 48.2 0.0 5.3e-10 39.0 0.0 2.3 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EGD94041.1 - 3.6e-11 42.8 0.0 2.4e-07 30.3 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EGD94041.1 - 1.4e-06 27.7 0.3 5e-06 25.9 0.0 1.8 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 EGD94041.1 - 0.00073 19.5 0.0 0.37 10.8 0.0 2.8 2 1 0 2 2 2 1 FAD-NAD(P)-binding 2-Hacid_dh_C PF02826.19 EGD94041.1 - 0.0025 17.2 0.1 1.4 8.2 0.1 2.4 2 0 0 2 2 2 2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Pyr_redox PF00070.27 EGD94041.1 - 0.0055 17.2 0.4 0.11 13.0 0.1 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_2 PF03446.15 EGD94041.1 - 0.019 15.1 0.1 0.043 14.0 0.1 1.6 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_8 PF13450.6 EGD94041.1 - 0.019 15.2 0.0 0.047 13.9 0.0 1.7 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain ELFV_dehydrog PF00208.21 EGD94041.1 - 0.05 13.3 0.1 0.49 10.1 0.0 2.1 2 0 0 2 2 2 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase UDPG_MGDP_dh_N PF03721.14 EGD94041.1 - 0.078 12.5 0.0 0.14 11.7 0.0 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain IlvN PF07991.12 EGD94041.1 - 0.079 12.5 0.0 2.3 7.8 0.0 2.5 2 0 0 2 2 2 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain Cas_Csa5 PF09702.10 EGD94041.1 - 0.079 13.2 0.0 0.16 12.2 0.0 1.4 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Csa5) NAD_binding_7 PF13241.6 EGD94041.1 - 0.12 12.8 0.0 4.8 7.7 0.0 2.4 2 0 0 2 2 2 0 Putative NAD(P)-binding Methyltransf_11 PF08241.12 EGD94041.1 - 0.17 12.5 0.0 0.37 11.5 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Shikimate_DH PF01488.20 EGD94041.1 - 0.19 11.8 0.0 3.2 7.8 0.0 2.3 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase Peptidase_M17_N PF02789.17 EGD94041.1 - 0.21 11.4 0.1 4 7.3 0.0 2.2 2 0 0 2 2 2 0 Cytosol aminopeptidase family, N-terminal domain adh_short PF00106.25 EGD94042.1 - 3.9e-35 121.1 0.4 3e-34 118.2 0.1 2.5 2 1 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 EGD94042.1 - 2.2e-32 112.5 0.3 4.7e-30 104.9 0.3 2.5 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EGD94042.1 - 2.2e-08 34.2 0.1 4.6e-08 33.2 0.1 1.5 1 0 0 1 1 1 1 KR domain Sacchrp_dh_NADP PF03435.18 EGD94042.1 - 0.02 15.1 0.1 0.035 14.3 0.1 1.3 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Epimerase PF01370.21 EGD94042.1 - 0.028 13.9 0.0 0.058 12.8 0.0 1.5 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family Pyr_redox PF00070.27 EGD94042.1 - 0.25 11.9 0.7 0.5 11.0 0.7 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Fasciclin PF02469.22 EGD94043.1 - 2.9e-35 121.3 0.0 8.4e-22 77.8 0.2 2.3 2 0 0 2 2 2 2 Fasciclin domain HHV-1_VABD PF16852.5 EGD94043.1 - 0.032 14.2 0.0 0.069 13.2 0.0 1.5 1 0 0 1 1 1 0 Herpes viral adaptor-to-host cellular mRNA binding domain Cu-oxidase_3 PF07732.15 EGD94044.1 - 2.1e-38 131.0 1.7 3e-38 130.5 0.4 2.0 2 0 0 2 2 2 1 Multicopper oxidase Cu-oxidase_2 PF07731.14 EGD94044.1 - 7.3e-25 87.3 12.1 1.1e-21 77.1 0.4 4.0 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase PF00394.22 EGD94044.1 - 7.4e-19 68.4 0.1 2.1e-18 67.0 0.1 1.8 1 1 0 1 1 1 1 Multicopper oxidase DUF4087 PF13316.6 EGD94044.1 - 0.076 13.5 0.0 1.4 9.5 0.0 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF4087) Methyltransf_2 PF00891.18 EGD94047.1 - 2.6e-26 92.2 0.0 4.6e-26 91.4 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_25 PF13649.6 EGD94047.1 - 0.024 15.3 0.0 0.2 12.4 0.0 2.6 3 0 0 3 3 3 0 Methyltransferase domain CheR PF01739.18 EGD94047.1 - 0.065 12.7 0.0 0.2 11.1 0.0 1.8 1 1 1 2 2 2 0 CheR methyltransferase, SAM binding domain Methyltransf_12 PF08242.12 EGD94047.1 - 0.075 13.8 0.0 0.35 11.6 0.0 2.2 2 0 0 2 2 2 0 Methyltransferase domain MFS_1 PF07690.16 EGD94048.1 - 9.3e-40 136.6 47.4 3.5e-39 134.7 47.4 1.9 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EGD94048.1 - 7.1e-11 41.6 29.8 4.6e-10 38.9 6.8 3.6 2 1 1 3 3 3 3 Sugar (and other) transporter Fungal_trans PF04082.18 EGD94049.1 - 1.4e-12 47.2 1.8 2.7e-12 46.3 1.8 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EGD94049.1 - 6.1e-08 32.6 12.7 1.2e-07 31.8 12.7 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain FAD_binding_4 PF01565.23 EGD94050.1 - 2e-17 63.2 2.1 4e-17 62.2 2.1 1.5 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EGD94050.1 - 2e-06 27.8 0.0 4.2e-06 26.8 0.0 1.5 1 0 0 1 1 1 1 Berberine and berberine like AflR PF08493.10 EGD94051.1 - 2.8e-07 30.3 6.6 2.8e-07 30.3 6.6 1.8 1 1 0 1 1 1 1 Aflatoxin regulatory protein CTV_P13 PF06922.11 EGD94051.1 - 0.16 12.0 0.0 0.77 9.8 0.0 2.0 2 0 0 2 2 2 0 Citrus tristeza virus P13 protein RGS12_usC PF16612.5 EGD94051.1 - 0.4 11.1 10.0 0.56 10.7 1.4 3.0 2 1 1 3 3 3 0 C-terminal unstructured region of RGS12 HNF-1_N PF04814.13 EGD94051.1 - 1 9.9 4.1 0.82 10.3 0.5 2.2 2 0 0 2 2 2 0 Hepatocyte nuclear factor 1 (HNF-1), N terminus Alpha_GJ PF03229.13 EGD94051.1 - 9.7 6.8 16.7 10 6.7 4.1 2.6 2 0 0 2 2 2 0 Alphavirus glycoprotein J p450 PF00067.22 EGD94053.1 - 9e-24 84.0 0.0 4.2e-22 78.5 0.0 2.2 2 0 0 2 2 2 2 Cytochrome P450 Transket_pyr PF02779.24 EGD94055.1 - 1.3e-42 145.5 0.0 2.1e-42 144.8 0.0 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 EGD94055.1 - 1.3e-31 109.1 0.0 3.1e-31 107.8 0.0 1.7 2 0 0 2 2 2 1 Transketolase, C-terminal domain PFOR_II PF17147.4 EGD94055.1 - 0.0086 16.4 0.0 0.017 15.4 0.0 1.5 1 0 0 1 1 1 1 Pyruvate:ferredoxin oxidoreductase core domain II DUF4200 PF13863.6 EGD94056.1 - 0.0031 17.9 23.2 0.0031 17.9 23.2 4.1 2 1 3 5 5 5 4 Domain of unknown function (DUF4200) zf-C4H2 PF10146.9 EGD94056.1 - 0.62 10.3 36.0 0.036 14.4 12.6 2.8 2 1 1 3 3 3 0 Zinc finger-containing protein DUF21 PF01595.20 EGD94057.1 - 4.1e-30 104.8 0.0 6.3e-30 104.2 0.0 1.2 1 0 0 1 1 1 1 Cyclin M transmembrane N-terminal domain CBS PF00571.28 EGD94057.1 - 0.0016 18.8 0.2 0.51 10.8 0.0 3.0 2 0 0 2 2 2 2 CBS domain His_Phos_1 PF00300.22 EGD94058.1 - 1.5e-15 57.4 0.0 3.1e-15 56.4 0.0 1.5 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) DUF1799 PF08809.11 EGD94058.1 - 0.085 13.0 0.4 0.21 11.8 0.1 1.8 2 0 0 2 2 2 0 Phage related hypothetical protein (DUF1799) Methyltransf_25 PF13649.6 EGD94058.1 - 0.17 12.6 0.0 0.38 11.5 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain AZUL PF16558.5 EGD94059.1 - 3.8e-22 78.3 2.3 3.8e-22 78.3 2.3 2.1 2 0 0 2 2 2 1 Amino-terminal Zinc-binding domain of ubiquitin ligase E3A HECT PF00632.25 EGD94059.1 - 1.6e-15 57.4 0.0 2.1e-12 47.2 0.0 2.2 2 0 0 2 2 2 2 HECT-domain (ubiquitin-transferase) zf-C2H2_2 PF12756.7 EGD94060.1 - 2.6e-35 120.8 20.1 1.2e-30 105.8 3.0 3.7 4 0 0 4 4 4 3 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.8 EGD94060.1 - 1.4e-09 38.0 18.5 1.7e-05 24.9 3.1 3.8 4 0 0 4 4 4 3 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EGD94060.1 - 1e-07 32.1 9.7 7e-06 26.3 3.5 2.9 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.6 EGD94060.1 - 0.00042 20.9 13.5 1.9 9.5 0.2 4.7 4 0 0 4 4 4 3 C2H2-type zinc finger DUF2024 PF09630.10 EGD94060.1 - 0.024 14.5 5.4 0.054 13.4 0.1 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF2024) Cytochrome-c551 PF10643.9 EGD94060.1 - 0.025 14.2 0.3 5.9 6.4 0.0 2.2 2 0 0 2 2 2 0 Photosystem P840 reaction-centre cytochrome c-551 zf-C2H2 PF00096.26 EGD94060.1 - 0.091 13.3 18.5 0.11 13.0 0.3 4.6 4 0 0 4 4 4 0 Zinc finger, C2H2 type Cytochrom_NNT PF03264.14 EGD94060.1 - 0.99 9.1 7.3 5.8 6.6 1.9 2.4 2 0 0 2 2 2 0 NapC/NirT cytochrome c family, N-terminal region Cytochrome_CBB3 PF13442.6 EGD94060.1 - 1.1 9.6 5.9 20 5.6 0.8 2.8 2 1 0 2 2 2 0 Cytochrome C oxidase, cbb3-type, subunit III Abhydrolase_3 PF07859.13 EGD94062.1 - 2.2e-06 27.7 0.0 5e-06 26.5 0.0 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EGD94062.1 - 0.00098 18.6 0.0 0.0016 18.0 0.0 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family Peptidase_S15 PF02129.18 EGD94062.1 - 0.0023 17.6 0.0 0.0036 16.9 0.0 1.2 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) Esterase PF00756.20 EGD94062.1 - 0.12 12.0 0.0 0.51 9.9 0.0 1.8 2 0 0 2 2 2 0 Putative esterase Pkinase PF00069.25 EGD94063.1 - 8e-70 235.2 0.0 1.1e-69 234.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD94063.1 - 3.9e-31 108.3 0.0 5.1e-31 107.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EGD94063.1 - 0.00018 20.9 0.0 0.00041 19.8 0.0 1.5 1 1 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 EGD94063.1 - 0.00081 18.4 0.1 0.018 14.0 0.0 2.0 2 0 0 2 2 2 1 Haspin like kinase domain APH PF01636.23 EGD94063.1 - 0.0025 17.8 0.1 0.0044 17.0 0.1 1.4 1 1 0 1 1 1 1 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 EGD94063.1 - 0.039 13.0 0.0 0.06 12.4 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 2OG-FeII_Oxy_2 PF13532.6 EGD94064.1 - 6.6e-14 52.5 0.0 7.1e-13 49.2 0.0 2.0 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily Glyco_trans_2_3 PF13632.6 EGD94064.1 - 0.019 14.9 0.1 0.037 13.9 0.1 1.4 1 0 0 1 1 1 0 Glycosyl transferase family group 2 zf-C2HC_2 PF13913.6 EGD94066.1 - 0.0014 18.5 0.0 0.003 17.4 0.0 1.5 1 0 0 1 1 1 1 zinc-finger of a C2HC-type zf-C2H2_4 PF13894.6 EGD94066.1 - 0.0072 17.1 0.3 0.017 15.9 0.3 1.7 1 0 0 1 1 1 1 C2H2-type zinc finger zf-Di19 PF05605.12 EGD94066.1 - 0.013 15.8 0.1 0.028 14.7 0.1 1.5 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding JAKMIP_CC3 PF16034.5 EGD94066.1 - 0.04 13.9 3.9 0.12 12.3 3.9 1.8 1 0 0 1 1 1 0 JAKMIP CC3 domain zf-C2H2 PF00096.26 EGD94066.1 - 0.058 13.9 0.4 0.12 12.8 0.4 1.6 1 0 0 1 1 1 0 Zinc finger, C2H2 type FAD_binding_3 PF01494.19 EGD94067.1 - 4.6e-14 52.4 1.7 2.5e-07 30.3 0.1 3.2 2 1 0 2 2 2 2 FAD binding domain FAD_binding_2 PF00890.24 EGD94067.1 - 0.00014 21.1 0.2 0.00076 18.7 0.1 1.9 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_2 PF07992.14 EGD94067.1 - 0.00038 19.8 0.1 0.0011 18.3 0.1 1.7 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EGD94067.1 - 0.00042 20.0 2.8 0.024 14.2 0.3 2.3 1 1 0 2 2 2 2 FAD dependent oxidoreductase Imm_superinfect PF14373.6 EGD94067.1 - 0.0054 16.6 1.4 0.0054 16.6 1.4 2.0 2 0 0 2 2 2 1 Superinfection immunity protein HI0933_like PF03486.14 EGD94067.1 - 0.095 11.4 0.0 0.14 10.8 0.0 1.2 1 0 0 1 1 1 0 HI0933-like protein MFS_1 PF07690.16 EGD94069.1 - 5.8e-43 147.2 41.2 5.8e-43 147.2 41.2 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EGD94069.1 - 7.6e-10 38.2 14.7 7.6e-10 38.2 14.7 2.6 2 1 0 2 2 2 2 Sugar (and other) transporter TRI12 PF06609.13 EGD94069.1 - 0.0021 16.6 6.2 0.0021 16.6 6.2 1.6 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Fungal_trans PF04082.18 EGD94070.1 - 1.4e-14 53.8 0.0 2.2e-14 53.2 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain ketoacyl-synt PF00109.26 EGD94071.1 - 8.9e-67 225.3 0.0 2e-66 224.1 0.0 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain KR PF08659.10 EGD94071.1 - 8.3e-49 165.9 0.0 1.7e-48 164.9 0.0 1.5 1 0 0 1 1 1 1 KR domain PS-DH PF14765.6 EGD94071.1 - 3.5e-45 154.5 0.0 5.6e-45 153.8 0.0 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase Acyl_transf_1 PF00698.21 EGD94071.1 - 3e-39 135.4 0.1 7.5e-39 134.1 0.1 1.6 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 EGD94071.1 - 2.9e-28 98.3 0.1 2.9e-28 98.3 0.1 2.3 3 0 0 3 3 2 1 Beta-ketoacyl synthase, C-terminal domain Methyltransf_12 PF08242.12 EGD94071.1 - 5.7e-20 71.9 0.0 1.7e-19 70.4 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain KAsynt_C_assoc PF16197.5 EGD94071.1 - 3.3e-15 56.5 0.0 8.3e-15 55.2 0.0 1.6 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Methyltransf_25 PF13649.6 EGD94071.1 - 9.9e-15 55.0 0.0 3.6e-14 53.2 0.0 2.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EGD94071.1 - 1e-12 48.5 0.0 2.8e-12 47.1 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EGD94071.1 - 7.2e-11 42.2 0.0 1.5e-10 41.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EGD94071.1 - 1.4e-09 37.9 0.0 3.7e-09 36.5 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain adh_short PF00106.25 EGD94071.1 - 1.7e-08 34.2 0.0 4.3e-08 32.8 0.0 1.7 1 0 0 1 1 1 1 short chain dehydrogenase Ubie_methyltran PF01209.18 EGD94071.1 - 1.4e-06 27.9 0.0 2.8e-06 26.8 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family adh_short_C2 PF13561.6 EGD94071.1 - 2e-06 27.5 0.0 4e-06 26.6 0.0 1.5 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase PP-binding PF00550.25 EGD94071.1 - 3.8e-05 24.0 0.3 0.0001 22.6 0.3 1.8 1 0 0 1 1 1 1 Phosphopantetheine attachment site Thiolase_N PF00108.23 EGD94071.1 - 9.1e-05 21.9 0.5 0.00066 19.1 0.1 2.2 2 0 0 2 2 2 1 Thiolase, N-terminal domain Methyltransf_16 PF10294.9 EGD94071.1 - 0.0036 17.1 0.0 0.0084 15.9 0.0 1.5 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_24 PF13578.6 EGD94071.1 - 0.009 17.0 0.0 0.043 14.8 0.0 2.2 2 0 0 2 2 1 1 Methyltransferase domain NodS PF05401.11 EGD94071.1 - 0.012 15.2 0.0 0.024 14.3 0.0 1.4 1 0 0 1 1 1 0 Nodulation protein S (NodS) Methyltransf_28 PF02636.17 EGD94071.1 - 0.05 13.2 0.0 0.09 12.4 0.0 1.3 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase SAT PF16073.5 EGD94071.1 - 0.059 13.1 1.9 4.8 6.8 0.3 2.5 2 0 0 2 2 2 0 Starter unit:ACP transacylase in aflatoxin biosynthesis AA_permease_2 PF13520.6 EGD94072.1 - 1.2e-57 195.7 47.7 1.5e-57 195.4 47.7 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EGD94072.1 - 2.2e-20 72.7 40.3 3e-20 72.3 40.3 1.1 1 0 0 1 1 1 1 Amino acid permease Plasmod_dom_1 PF09715.10 EGD94072.1 - 0.18 11.9 1.0 0.66 10.1 1.0 2.1 1 0 0 1 1 1 0 Plasmodium protein of unknown function (Plasmod_dom_1) DUF3237 PF11578.8 EGD94074.1 - 7.5e-07 29.1 0.1 1.1e-06 28.5 0.1 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF3237) DLH PF01738.18 EGD94076.1 - 3.3e-14 53.0 0.0 4.2e-14 52.6 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family Cu-oxidase_3 PF07732.15 EGD94077.1 - 4.6e-44 149.2 0.1 4.1e-43 146.2 0.2 2.2 2 0 0 2 2 2 1 Multicopper oxidase Cu-oxidase_2 PF07731.14 EGD94077.1 - 4.9e-39 133.2 3.6 1e-35 122.4 0.1 4.1 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase PF00394.22 EGD94077.1 - 6.5e-32 110.8 0.1 2.1e-31 109.2 0.0 2.0 2 0 0 2 2 2 1 Multicopper oxidase Atx10homo_assoc PF09759.9 EGD94077.1 - 0.062 13.3 0.0 0.14 12.2 0.0 1.5 1 0 0 1 1 1 0 Spinocerebellar ataxia type 10 protein domain LysM PF01476.20 EGD94079.1 - 1.7e-14 53.6 0.0 1.5e-07 31.3 0.0 3.2 3 0 0 3 3 3 3 LysM domain MFS_1 PF07690.16 EGD94080.1 - 2.1e-22 79.5 47.7 1.1e-14 54.1 23.4 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Cutinase PF01083.22 EGD94081.1 - 3.3e-11 43.4 0.0 5.2e-07 29.8 0.2 2.1 2 0 0 2 2 2 2 Cutinase Glyco_hydro_cc PF11790.8 EGD94083.1 - 2.8e-61 207.1 1.6 3.3e-61 206.9 1.6 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase catalytic core Peptidase_S8 PF00082.22 EGD94084.1 - 4.1e-37 128.0 2.5 6.1e-37 127.5 2.5 1.2 1 0 0 1 1 1 1 Subtilase family P_proprotein PF01483.20 EGD94084.1 - 1.4e-25 89.1 0.7 1.4e-25 89.1 0.7 2.4 2 0 0 2 2 2 1 Proprotein convertase P-domain Rimk_N PF18030.1 EGD94085.1 - 0.19 12.1 0.0 5.1 7.6 0.0 2.1 1 1 1 2 2 2 0 RimK PreATP-grasp domain DUF3328 PF11807.8 EGD94086.1 - 5.2e-26 91.8 5.7 6.9e-26 91.4 5.7 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) DUF3328 PF11807.8 EGD94087.1 - 1.3e-15 57.8 0.6 1.2e-14 54.6 0.6 2.0 1 1 0 1 1 1 1 Domain of unknown function (DUF3328) Methyltransf_2 PF00891.18 EGD94088.1 - 1.9e-22 79.6 0.0 3.3e-22 78.8 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_23 PF13489.6 EGD94088.1 - 1.4e-05 25.0 0.0 2.3e-05 24.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EGD94088.1 - 0.00011 22.9 0.1 0.003 18.2 0.0 2.7 3 0 0 3 3 3 1 Methyltransferase domain CheR PF01739.18 EGD94088.1 - 0.0014 18.2 0.0 0.0028 17.2 0.0 1.4 1 0 0 1 1 1 1 CheR methyltransferase, SAM binding domain MTS PF05175.14 EGD94088.1 - 0.021 14.4 0.0 0.052 13.1 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_12 PF08242.12 EGD94088.1 - 0.14 12.9 0.0 0.7 10.7 0.0 2.3 2 1 0 2 2 2 0 Methyltransferase domain DUF1998 PF09369.10 EGD94089.1 - 9.9e-19 67.9 0.3 3.8e-18 66.0 0.3 2.0 1 1 0 1 1 1 1 Domain of unknown function (DUF1998) Pox_A9 PF04835.12 EGD94089.1 - 0.075 13.2 0.1 0.85 9.8 0.0 2.2 2 0 0 2 2 2 0 A9 protein conserved region Acylphosphatase PF00708.18 EGD94089.1 - 0.15 12.4 0.0 7.1 7.1 0.0 2.4 2 0 0 2 2 2 0 Acylphosphatase Fungal_trans_2 PF11951.8 EGD94090.1 - 1.6e-10 40.4 6.2 7.5e-10 38.2 6.2 1.9 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EGD94090.1 - 8.5e-06 25.8 10.8 1.7e-05 24.8 10.8 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Opy2 PF09463.10 EGD94090.1 - 2.2 8.7 7.9 0.96 9.8 3.8 2.4 2 0 0 2 2 2 0 Opy2 protein NUDE_C PF04880.13 EGD94090.1 - 4.5 7.7 7.2 10 6.6 7.2 1.5 1 0 0 1 1 1 0 NUDE protein, C-terminal conserved region DUF3583 PF12126.8 EGD94090.1 - 6 6.2 6.6 10 5.4 6.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3583) MFS_1 PF07690.16 EGD94091.1 - 3.4e-18 65.7 30.1 7.7e-17 61.2 15.5 2.8 3 0 0 3 3 3 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EGD94091.1 - 6.2e-10 38.5 8.5 6.2e-10 38.5 8.5 2.5 3 0 0 3 3 3 2 Sugar (and other) transporter TRI12 PF06609.13 EGD94091.1 - 6.7e-06 24.8 7.5 0.00052 18.6 2.2 2.5 3 0 0 3 3 3 2 Fungal trichothecene efflux pump (TRI12) AMP-binding PF00501.28 EGD94092.1 - 6.9e-49 166.6 0.0 1e-48 166.0 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme PP-binding PF00550.25 EGD94092.1 - 2e-15 56.8 0.1 4.1e-15 55.9 0.1 1.5 1 0 0 1 1 1 1 Phosphopantetheine attachment site Hexapep PF00132.24 EGD94092.1 - 1.7e-10 40.2 9.0 2.1e-05 24.1 0.3 6.4 6 2 0 6 6 6 3 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 EGD94092.1 - 1.1e-06 28.3 19.2 0.012 15.3 0.1 5.6 5 1 1 6 6 6 4 Hexapeptide repeat of succinyl-transferase PUNUT PF16913.5 EGD94092.1 - 0.047 12.9 0.6 0.1 11.8 0.1 1.8 2 0 0 2 2 2 0 Purine nucleobase transmembrane transport zf-RING_2 PF13639.6 EGD94093.1 - 1.4e-12 47.8 8.2 2.1e-12 47.2 8.2 1.3 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 EGD94093.1 - 3.3e-09 36.9 5.0 6.5e-09 36.0 5.0 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 EGD94093.1 - 2.4e-07 30.5 6.6 3.9e-07 29.8 6.6 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EGD94093.1 - 2.4e-06 27.2 5.5 4.4e-06 26.3 5.5 1.4 1 0 0 1 1 1 1 RING-like zinc finger Zn_ribbon_17 PF17120.5 EGD94093.1 - 6.5e-06 25.7 4.4 1.2e-05 24.9 4.4 1.3 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-C3HC4 PF00097.25 EGD94093.1 - 1.2e-05 25.1 8.1 1.9e-05 24.4 8.1 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 EGD94093.1 - 0.00011 22.2 2.9 0.00028 20.9 2.9 1.6 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_5 PF14634.6 EGD94093.1 - 0.00026 20.9 6.2 0.00039 20.3 6.2 1.3 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 EGD94093.1 - 0.00034 20.4 5.2 0.00057 19.7 5.2 1.3 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 EGD94093.1 - 0.002 18.1 6.0 0.0041 17.1 6.0 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 EGD94093.1 - 0.0027 17.5 5.8 0.0045 16.8 5.8 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3H2C3 PF17122.5 EGD94093.1 - 0.0069 16.4 1.6 0.014 15.4 1.6 1.4 1 0 0 1 1 1 1 Zinc-finger zf-Nse PF11789.8 EGD94093.1 - 0.063 13.1 3.3 0.12 12.2 3.3 1.4 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit RINGv PF12906.7 EGD94093.1 - 0.068 13.3 9.0 0.11 12.6 9.0 1.4 1 0 0 1 1 1 0 RING-variant domain FANCL_C PF11793.8 EGD94093.1 - 0.11 12.7 5.7 0.21 11.8 5.7 1.4 1 0 0 1 1 1 0 FANCL C-terminal domain zf-RING-like PF08746.11 EGD94093.1 - 0.24 11.7 1.8 0.48 10.8 1.8 1.4 1 0 0 1 1 1 0 RING-like domain Prok-RING_1 PF14446.6 EGD94093.1 - 3.4 7.7 8.0 0.68 9.9 4.2 1.6 1 1 0 1 1 1 0 Prokaryotic RING finger family 1 ECM11 PF15463.6 EGD94094.1 - 3.1e-39 134.6 0.0 8.2e-39 133.2 0.0 1.8 1 0 0 1 1 1 1 Extracellular mutant protein 11 FAM216B PF15107.6 EGD94094.1 - 0.039 13.8 0.0 0.075 12.9 0.0 1.4 1 0 0 1 1 1 0 FAM216B protein family RNA_pol_I_TF PF04090.12 EGD94095.1 - 2e-06 27.5 0.0 0.002 17.7 0.0 2.2 2 0 0 2 2 2 2 RNA polymerase I specific initiation factor OmpH PF03938.14 EGD94095.1 - 4.8 7.5 8.4 2.3 8.5 0.3 2.9 3 0 0 3 3 3 0 Outer membrane protein (OmpH-like) bZIP_Maf PF03131.17 EGD94096.1 - 1.4e-05 25.5 15.3 1.4e-05 25.5 15.3 2.9 1 1 1 2 2 2 1 bZIP Maf transcription factor bZIP_2 PF07716.15 EGD94096.1 - 0.0002 21.4 11.6 0.0002 21.4 11.6 3.4 2 1 1 3 3 3 1 Basic region leucine zipper bZIP_1 PF00170.21 EGD94096.1 - 0.00027 21.0 14.2 0.00027 21.0 14.2 3.2 1 1 2 3 3 3 1 bZIP transcription factor DUF1062 PF06353.12 EGD94096.1 - 0.15 12.9 9.3 1 10.2 7.7 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1062) AAA_23 PF13476.6 EGD94096.1 - 1.4 9.3 10.3 2.9 8.3 10.3 1.6 1 0 0 1 1 1 0 AAA domain zf-CCCH PF00642.24 EGD94100.1 - 4.7e-13 48.7 26.2 0.00056 19.8 1.3 5.3 5 0 0 5 5 5 4 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 EGD94100.1 - 5.5e-08 32.6 28.3 0.0064 16.5 0.5 5.9 5 1 0 5 5 5 4 Zinc finger domain zf-CCCH_3 PF15663.5 EGD94100.1 - 0.0018 18.5 14.1 0.022 15.0 1.1 3.7 1 1 2 3 3 3 2 Zinc-finger containing family Torus PF16131.5 EGD94100.1 - 0.01 16.5 25.3 0.31 11.8 1.0 4.9 2 1 3 5 5 5 0 Torus domain zf-C3H1 PF10650.9 EGD94100.1 - 1.2 8.9 0.0 1.2 8.9 0.0 4.0 5 0 0 5 5 5 0 Putative zinc-finger domain FXMRP1_C_core PF12235.8 EGD94100.1 - 6.2 7.5 15.4 15 6.2 13.5 2.4 2 1 0 2 2 2 0 Fragile X-related 1 protein core C terminal TFIIF_beta_N PF17683.1 EGD94101.1 - 9.5e-32 110.5 0.9 1.7e-31 109.7 0.9 1.4 1 0 0 1 1 1 1 TFIIF, beta subunit N-terminus TFIIF_beta PF02270.15 EGD94101.1 - 3.9e-28 97.4 0.3 7.2e-28 96.5 0.3 1.5 1 0 0 1 1 1 1 TFIIF, beta subunit HTH domain Tau95 PF09734.9 EGD94101.1 - 0.015 16.1 6.5 0.088 13.6 6.5 2.1 1 1 0 1 1 1 0 RNA polymerase III transcription factor (TF)IIIC subunit HTH domain PCI PF01399.27 EGD94102.1 - 1.9e-11 44.4 0.0 4.4e-11 43.2 0.0 1.7 1 0 0 1 1 1 1 PCI domain RPN7 PF10602.9 EGD94102.1 - 1.2e-07 31.6 0.1 2.3e-07 30.7 0.1 1.4 1 0 0 1 1 1 1 26S proteasome subunit RPN7 NAD_binding_4 PF07993.12 EGD94103.1 - 1.7e-32 112.6 0.0 5.3e-32 111.0 0.0 1.8 2 0 0 2 2 2 1 Male sterility protein AMP-binding PF00501.28 EGD94103.1 - 1.4e-24 86.5 0.0 3.7e-24 85.1 0.0 1.6 2 0 0 2 2 2 1 AMP-binding enzyme Epimerase PF01370.21 EGD94103.1 - 4.3e-11 42.7 0.0 7.6e-11 41.9 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family PP-binding PF00550.25 EGD94103.1 - 5.4e-10 39.5 0.0 1.4e-09 38.2 0.0 1.8 1 0 0 1 1 1 1 Phosphopantetheine attachment site Polysacc_synt_2 PF02719.15 EGD94103.1 - 0.092 11.9 0.0 0.16 11.0 0.0 1.4 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein p450 PF00067.22 EGD94104.1 - 4.7e-76 256.4 0.0 5.2e-76 256.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 adh_short PF00106.25 EGD94105.1 - 2.9e-20 72.5 0.1 1.7e-16 60.3 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EGD94105.1 - 2.6e-08 33.7 0.0 5.7e-05 22.8 0.0 2.2 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EGD94105.1 - 5e-07 29.8 0.1 1e-06 28.8 0.1 1.5 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.6 EGD94106.1 - 6.8e-62 209.1 2.5 2.1e-61 207.5 2.5 1.6 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EGD94106.1 - 2.1e-43 148.1 1.2 3.6e-43 147.3 1.2 1.3 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EGD94106.1 - 5.3e-10 39.5 0.3 5.3e-10 39.5 0.3 1.8 2 0 0 2 2 2 1 KR domain Fungal_trans PF04082.18 EGD94107.1 - 1.3e-07 31.0 0.0 4.4e-07 29.2 0.0 1.8 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EGD94107.1 - 5.5e-07 29.6 8.2 5.5e-07 29.6 8.2 2.5 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain ketoacyl-synt PF00109.26 EGD94108.1 - 2.5e-79 266.4 0.1 6e-79 265.2 0.1 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain KR PF08659.10 EGD94108.1 - 2.5e-61 206.7 0.0 3.2e-60 203.1 0.0 2.6 3 0 0 3 3 3 1 KR domain Acyl_transf_1 PF00698.21 EGD94108.1 - 7e-60 203.2 0.0 1.4e-59 202.2 0.0 1.5 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 EGD94108.1 - 9.8e-43 144.9 0.6 2.5e-42 143.6 0.6 1.8 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain KAsynt_C_assoc PF16197.5 EGD94108.1 - 2e-13 50.8 0.0 4.6e-13 49.6 0.0 1.7 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension PP-binding PF00550.25 EGD94108.1 - 6.1e-13 48.9 0.1 7.2e-12 45.5 0.0 2.5 2 0 0 2 2 2 1 Phosphopantetheine attachment site PS-DH PF14765.6 EGD94108.1 - 1.3e-11 44.3 0.0 2.5e-11 43.4 0.0 1.5 1 1 0 1 1 1 1 Polyketide synthase dehydratase adh_short PF00106.25 EGD94108.1 - 4.9e-06 26.1 0.1 0.00043 19.8 0.0 3.2 3 1 0 3 3 3 1 short chain dehydrogenase Thiolase_N PF00108.23 EGD94108.1 - 1.5e-05 24.5 1.7 6.7e-05 22.4 0.8 2.5 2 0 0 2 2 2 1 Thiolase, N-terminal domain KfrA_N PF11740.8 EGD94108.1 - 0.082 13.6 0.0 0.31 11.7 0.0 2.0 1 0 0 1 1 1 0 Plasmid replication region DNA-binding N-term MFS_1 PF07690.16 EGD94109.1 - 8.1e-24 84.2 30.0 1e-23 83.8 30.0 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily WD40 PF00400.32 EGD94110.1 - 4.2e-13 49.6 4.8 0.11 13.4 0.2 6.7 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EGD94110.1 - 0.0066 16.7 0.1 2.4 8.5 0.0 3.7 3 2 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain FAD_binding_2 PF00890.24 EGD94112.1 - 1.1e-58 199.3 0.5 2.1e-58 198.4 0.5 1.4 1 0 0 1 1 1 1 FAD binding domain Cyt-b5 PF00173.28 EGD94112.1 - 2.1e-21 75.8 0.0 4.9e-20 71.5 0.1 2.9 3 0 0 3 3 3 1 Cytochrome b5-like Heme/Steroid binding domain DAO PF01266.24 EGD94112.1 - 4.3e-12 46.3 0.6 1.1e-11 44.9 0.6 1.6 1 1 0 1 1 1 1 FAD dependent oxidoreductase FAD_oxidored PF12831.7 EGD94112.1 - 2.5e-10 40.3 1.2 1e-09 38.2 1.2 1.9 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EGD94112.1 - 1.7e-08 34.5 1.3 6.9e-08 32.6 0.2 2.5 2 1 1 3 3 3 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EGD94112.1 - 3.6e-07 29.7 0.2 8.5e-07 28.5 0.2 1.7 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EGD94112.1 - 8.7e-07 28.5 0.0 0.0064 15.8 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EGD94112.1 - 1.8e-05 23.6 1.0 0.00011 21.1 1.0 2.1 1 1 0 1 1 1 1 HI0933-like protein GIDA PF01134.22 EGD94112.1 - 8.4e-05 21.8 1.7 0.023 13.8 0.3 2.2 2 0 0 2 2 2 2 Glucose inhibited division protein A FAD_binding_3 PF01494.19 EGD94112.1 - 0.00049 19.5 0.1 0.00081 18.7 0.1 1.2 1 0 0 1 1 1 1 FAD binding domain Pyr_redox PF00070.27 EGD94112.1 - 0.024 15.2 1.4 5.5 7.6 0.1 2.9 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EGD94112.1 - 0.034 13.4 0.1 0.066 12.4 0.1 1.5 1 0 0 1 1 1 0 Thi4 family Amino_oxidase PF01593.24 EGD94112.1 - 0.1 11.9 0.4 2.6 7.2 0.0 2.9 2 1 1 3 3 3 0 Flavin containing amine oxidoreductase PAP1 PF08601.10 EGD94112.1 - 3.3 7.3 7.3 5 6.8 7.3 1.2 1 0 0 1 1 1 0 Transcription factor PAP1 Sin3a_C PF16879.5 EGD94113.1 - 1.3e-77 261.4 0.1 1.3e-77 261.4 0.1 3.4 4 0 0 4 4 4 1 C-terminal domain of Sin3a protein PAH PF02671.21 EGD94113.1 - 3.3e-43 145.6 1.1 9.3e-18 64.1 0.0 3.8 3 0 0 3 3 3 3 Paired amphipathic helix repeat Sin3_corepress PF08295.12 EGD94113.1 - 3.3e-40 136.1 0.0 9.2e-40 134.7 0.0 1.8 1 0 0 1 1 1 1 Sin3 family co-repressor Glyco_hydro_17 PF00332.18 EGD94114.1 - 0.00032 20.4 0.2 0.0039 16.8 0.1 2.2 2 0 0 2 2 2 1 Glycosyl hydrolases family 17 MFS_1 PF07690.16 EGD94115.1 - 4.6e-41 140.9 65.0 1.7e-39 135.7 64.8 3.3 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EGD94115.1 - 1.6e-15 56.6 25.3 2.6e-15 55.9 25.3 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 EGD94115.1 - 8.3e-15 54.6 9.5 8.3e-15 54.6 9.5 2.5 3 0 0 3 3 3 1 Sugar (and other) transporter OATP PF03137.20 EGD94115.1 - 2.7 6.2 14.4 0.24 9.6 3.5 2.7 2 1 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family Sel1 PF08238.12 EGD94116.1 - 2.5e-38 129.6 31.1 1.6e-05 25.4 0.1 7.5 7 0 0 7 7 7 7 Sel1 repeat TPR_6 PF13174.6 EGD94116.1 - 0.023 15.3 5.1 3.1 8.7 0.3 4.6 4 1 0 4 4 4 0 Tetratricopeptide repeat Chitin_synth_2 PF03142.15 EGD94117.1 - 1.9e-290 964.0 0.1 3e-290 963.3 0.1 1.3 1 0 0 1 1 1 1 Chitin synthase Glyco_trans_2_3 PF13632.6 EGD94117.1 - 4.7e-13 49.5 2.3 1.4e-12 47.9 2.3 1.9 1 1 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 EGD94117.1 - 3.1e-09 37.1 0.0 7.8e-09 35.8 0.0 1.7 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 EGD94117.1 - 0.00014 21.4 0.1 0.0019 17.7 0.0 2.1 2 0 0 2 2 2 1 Glycosyl transferase family 21 Glycos_transf_2 PF00535.26 EGD94117.1 - 0.01 15.7 0.1 0.088 12.6 0.0 2.3 2 0 0 2 2 2 0 Glycosyl transferase family 2 Selenoprotein_S PF06936.11 EGD94117.1 - 1.4 8.7 7.7 3.3 7.5 5.9 2.1 2 0 0 2 2 2 0 Selenoprotein S (SelS) RskA PF10099.9 EGD94118.1 - 0.0067 16.7 3.1 0.012 15.9 0.9 2.0 2 0 0 2 2 2 1 Anti-sigma-K factor rskA WD40 PF00400.32 EGD94119.1 - 9.3e-05 23.1 2.3 0.02 15.8 0.1 3.7 3 0 0 3 3 3 1 WD domain, G-beta repeat LRR19-TM PF15176.6 EGD94119.1 - 0.16 12.0 0.3 0.47 10.5 0.3 1.7 1 0 0 1 1 1 0 Leucine-rich repeat family 19 TM domain SUIM_assoc PF16619.5 EGD94120.1 - 4.7 7.3 20.1 83 3.4 11.6 3.7 3 1 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 ATG22 PF11700.8 EGD94121.1 - 7.7e-132 440.3 28.6 9.4e-132 440.0 28.6 1.1 1 0 0 1 1 1 1 Vacuole effluxer Atg22 like MFS_1 PF07690.16 EGD94121.1 - 1.7e-11 43.7 33.5 1.1e-06 27.8 8.0 3.1 2 1 1 3 3 3 3 Major Facilitator Superfamily Ras PF00071.22 EGD94122.1 - 8.3e-59 197.8 0.2 9.6e-59 197.6 0.2 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EGD94122.1 - 2.6e-36 124.5 0.2 4.4e-36 123.7 0.1 1.4 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EGD94122.1 - 1.1e-14 54.3 0.1 1.3e-14 54.0 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EGD94122.1 - 2.8e-07 30.3 0.0 3.9e-07 29.8 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EGD94122.1 - 6.2e-07 29.5 0.0 9.9e-07 28.8 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EGD94122.1 - 1.4e-06 27.9 0.0 1.7e-06 27.5 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 EGD94122.1 - 2.1e-05 24.5 1.1 0.19 11.6 0.2 2.4 1 1 2 3 3 3 2 RsgA GTPase AAA_16 PF13191.6 EGD94122.1 - 0.011 16.1 0.2 0.028 14.8 0.2 1.7 1 1 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 EGD94122.1 - 0.056 13.7 0.0 3.1 8.1 0.0 2.3 1 1 1 2 2 2 0 AAA domain AAT PF03417.16 EGD94122.1 - 0.14 11.8 0.2 0.21 11.3 0.2 1.2 1 0 0 1 1 1 0 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase Mitofilin PF09731.9 EGD94123.1 - 1.4e-153 513.1 28.3 1.9e-126 423.5 25.0 2.2 1 1 1 2 2 2 2 Mitochondrial inner membrane protein ATP-synt_B PF00430.18 EGD94123.1 - 0.014 15.4 19.1 0.41 10.7 8.2 2.7 1 1 1 2 2 2 0 ATP synthase B/B' CF(0) Focal_AT PF03623.13 EGD94123.1 - 0.048 13.7 1.6 0.12 12.4 0.3 2.1 1 1 1 2 2 2 0 Focal adhesion targeting region Ribosomal_L20 PF00453.18 EGD94123.1 - 0.069 13.2 2.3 0.16 12.1 2.3 1.6 1 0 0 1 1 1 0 Ribosomal protein L20 ArnB_C PF18677.1 EGD94123.1 - 0.097 12.8 8.9 11 6.2 0.0 4.0 4 0 0 4 4 4 0 Archaellum regulatory network B, C-terminal domain DUF2205 PF10224.9 EGD94123.1 - 0.36 10.9 7.1 0.13 12.2 2.3 2.6 1 1 0 2 2 2 0 Short coiled-coil protein YqhG PF11079.8 EGD94123.1 - 0.55 9.1 3.4 0.94 8.4 3.4 1.3 1 0 0 1 1 1 0 Bacterial protein YqhG of unknown function DUF4363 PF14276.6 EGD94123.1 - 4.1 7.6 10.7 1.6 8.9 0.0 3.5 2 1 1 3 3 3 0 Domain of unknown function (DUF4363) DSBA PF01323.20 EGD94127.1 - 2e-12 47.3 0.0 2.9e-12 46.8 0.0 1.2 1 0 0 1 1 1 1 DSBA-like thioredoxin domain Bromodomain PF00439.25 EGD94128.1 - 2.7e-21 75.4 0.3 5e-21 74.6 0.3 1.4 1 0 0 1 1 1 1 Bromodomain Acetyltransf_1 PF00583.25 EGD94128.1 - 9e-08 32.4 0.1 1.7e-07 31.5 0.1 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EGD94128.1 - 4.9e-07 29.7 0.1 9.6e-07 28.8 0.1 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EGD94128.1 - 5.3e-05 23.6 0.2 0.00012 22.4 0.2 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EGD94128.1 - 0.088 12.8 0.0 0.16 11.9 0.0 1.3 1 0 0 1 1 1 0 FR47-like protein Methyltransf_16 PF10294.9 EGD94130.1 - 3e-49 167.1 0.0 4.4e-49 166.6 0.0 1.2 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_25 PF13649.6 EGD94130.1 - 1.6e-05 25.5 0.1 7.6e-05 23.3 0.0 2.1 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EGD94130.1 - 4e-05 23.5 0.1 0.00021 21.1 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 EGD94130.1 - 0.00044 20.1 0.0 0.00067 19.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EGD94130.1 - 0.0016 18.0 0.0 0.003 17.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_12 PF08242.12 EGD94130.1 - 0.0024 18.6 0.1 0.0096 16.7 0.0 2.0 2 1 0 2 2 2 1 Methyltransferase domain VWA_CoxE PF05762.14 EGD94130.1 - 0.026 13.9 0.1 0.057 12.8 0.1 1.6 2 0 0 2 2 2 0 VWA domain containing CoxE-like protein PrmA PF06325.13 EGD94130.1 - 0.03 13.7 0.1 0.047 13.1 0.1 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Orn_Arg_deC_N PF02784.16 EGD94131.1 - 4.1e-83 278.5 0.0 6.7e-83 277.9 0.0 1.3 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.22 EGD94131.1 - 6.3e-18 64.8 0.0 7.7e-18 64.5 0.0 1.3 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain AP_endonuc_2 PF01261.24 EGD94131.1 - 0.01 15.3 0.0 0.021 14.2 0.0 1.5 1 0 0 1 1 1 0 Xylose isomerase-like TIM barrel Luteo_P1-P2 PF08467.10 EGD94131.1 - 0.014 14.6 0.0 0.021 14.1 0.0 1.2 1 0 0 1 1 1 0 Luteovirus RNA polymerase P1-P2/replicase cobW PF02492.19 EGD94132.1 - 7.1e-42 143.0 0.0 1.1e-41 142.3 0.0 1.3 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain MobB PF03205.14 EGD94132.1 - 0.00076 19.4 0.0 0.0017 18.2 0.0 1.5 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_22 PF13401.6 EGD94132.1 - 0.027 14.7 0.0 0.068 13.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain Viral_helicase1 PF01443.18 EGD94132.1 - 0.04 13.7 0.0 0.12 12.1 0.0 1.8 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase Pox_A32 PF04665.12 EGD94132.1 - 0.12 11.8 0.1 0.29 10.5 0.0 1.6 2 0 0 2 2 2 0 Poxvirus A32 protein AAA_29 PF13555.6 EGD94132.1 - 0.15 11.9 0.3 1.2 8.9 0.2 2.3 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_14 PF13173.6 EGD94132.1 - 0.21 11.6 0.0 0.43 10.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain SET PF00856.28 EGD94133.1 - 6.6e-07 29.9 0.1 1.2e-06 29.1 0.1 1.3 1 1 0 1 1 1 1 SET domain Glyco_transf_54 PF04666.13 EGD94134.1 - 1.1e-12 47.5 0.0 8.8e-09 34.6 0.0 3.1 2 1 0 2 2 2 2 N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region DUF2754 PF10953.8 EGD94134.1 - 0.0085 16.3 0.2 0.019 15.2 0.2 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2754) DUF3431 PF11913.8 EGD94135.1 - 1.5e-87 292.9 0.0 1.8e-87 292.6 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3431) MGC-24 PF05283.11 EGD94136.1 - 0.2 12.1 0.2 0.33 11.4 0.2 1.3 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin DNA_mis_repair PF01119.19 EGD94137.1 - 5.5e-11 42.2 0.0 1.2e-10 41.1 0.0 1.6 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.6 EGD94137.1 - 3.9e-06 26.7 0.1 8.5e-06 25.6 0.1 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 EGD94137.1 - 1.6e-05 25.4 0.0 4e-05 24.1 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase APH PF01636.23 EGD94138.1 - 3.2e-10 40.3 0.0 8.2e-10 39.0 0.0 1.6 1 1 0 1 1 1 1 Phosphotransferase enzyme family MFS_1 PF07690.16 EGD94139.1 - 1.2e-31 110.0 29.4 1.2e-31 110.0 29.4 1.7 2 0 0 2 2 2 1 Major Facilitator Superfamily Chordopox_A13L PF05961.11 EGD94139.1 - 0.092 13.0 0.0 0.21 11.9 0.0 1.6 1 0 0 1 1 1 0 Chordopoxvirus A13L protein DHHC PF01529.20 EGD94140.1 - 2.1e-32 112.0 5.9 2.1e-32 112.0 5.9 1.8 2 0 0 2 2 2 1 DHHC palmitoyltransferase DUF2254 PF10011.9 EGD94140.1 - 0.033 13.0 0.2 0.05 12.4 0.2 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2254) Acetyltransf_3 PF13302.7 EGD94141.1 - 1.8e-26 93.5 0.1 2.8e-26 92.8 0.0 1.3 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EGD94141.1 - 0.0006 20.0 0.0 0.00082 19.6 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_8 PF13523.6 EGD94141.1 - 0.0022 17.7 0.0 0.005 16.5 0.0 1.5 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain FeoB_Cyto PF17910.1 EGD94141.1 - 0.14 12.7 0.0 0.24 12.0 0.0 1.3 1 0 0 1 1 1 0 FeoB cytosolic helical domain Pkinase PF00069.25 EGD94142.1 - 2.3e-72 243.6 0.0 3.7e-72 242.9 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD94142.1 - 6.6e-45 153.4 0.0 1.1e-44 152.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EGD94142.1 - 7.5e-06 25.5 0.0 1.9e-05 24.2 0.0 1.5 1 1 0 1 1 1 1 Kinase-like POLO_box PF00659.18 EGD94142.1 - 8.6e-06 25.9 0.0 0.058 13.6 0.0 3.0 2 0 0 2 2 2 2 POLO box duplicated region Haspin_kinase PF12330.8 EGD94142.1 - 0.014 14.4 0.2 0.028 13.4 0.2 1.4 1 0 0 1 1 1 0 Haspin like kinase domain Kdo PF06293.14 EGD94142.1 - 0.059 12.7 0.0 0.1 12.0 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EGD94142.1 - 0.072 11.8 0.0 0.072 11.8 0.0 2.0 2 1 0 2 2 2 0 Fungal protein kinase OPA3 PF07047.12 EGD94143.1 - 1.4e-48 163.8 1.8 2e-48 163.3 1.8 1.2 1 0 0 1 1 1 1 Optic atrophy 3 protein (OPA3) Med11 PF10280.9 EGD94143.1 - 0.00099 19.6 0.3 0.00099 19.6 0.3 2.1 2 0 0 2 2 2 1 Mediator complex protein TPD52 PF04201.15 EGD94143.1 - 0.37 10.4 5.3 0.17 11.5 0.9 2.1 2 0 0 2 2 2 0 Tumour protein D52 family DUF4472 PF14739.6 EGD94143.1 - 0.53 11.0 7.5 0.3 11.8 0.9 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4472) Myosin_head PF00063.21 EGD94144.1 - 3.8e-241 802.0 4.7 4.6e-241 801.8 4.7 1.0 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_TH1 PF06017.13 EGD94144.1 - 9.2e-50 168.9 0.0 1.6e-49 168.1 0.0 1.4 1 0 0 1 1 1 1 Unconventional myosin tail, actin- and lipid-binding SH3_1 PF00018.28 EGD94144.1 - 9.8e-12 44.3 0.0 2.1e-11 43.2 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 EGD94144.1 - 2.5e-09 36.7 0.0 7.8e-09 35.1 0.0 1.9 2 0 0 2 2 2 1 Variant SH3 domain SH3_9 PF14604.6 EGD94144.1 - 4e-09 36.2 0.0 1e-08 34.9 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain IQ PF00612.27 EGD94144.1 - 0.0095 15.7 8.7 0.5 10.3 0.6 2.7 2 0 0 2 2 2 2 IQ calmodulin-binding motif AAA_22 PF13401.6 EGD94144.1 - 0.012 15.9 0.0 0.041 14.2 0.0 1.9 2 0 0 2 2 1 0 AAA domain AAA_16 PF13191.6 EGD94144.1 - 0.016 15.6 0.0 0.047 14.1 0.0 1.8 1 0 0 1 1 1 0 AAA ATPase domain Hpr_kinase_C PF07475.12 EGD94144.1 - 0.02 14.4 0.5 3.4 7.2 0.0 2.6 2 0 0 2 2 2 0 HPr Serine kinase C-terminal domain TrwB_AAD_bind PF10412.9 EGD94144.1 - 0.15 11.0 0.1 0.31 9.9 0.0 1.5 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain AAA_33 PF13671.6 EGD94144.1 - 0.16 12.1 0.2 5.5 7.1 0.0 3.2 4 0 0 4 4 4 0 AAA domain NACHT PF05729.12 EGD94144.1 - 0.19 11.7 0.0 0.49 10.3 0.0 1.7 1 0 0 1 1 1 0 NACHT domain p450 PF00067.22 EGD94147.1 - 1.7e-49 168.8 0.0 2.4e-49 168.3 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Methyltransf_23 PF13489.6 EGD94148.1 - 1.2e-17 64.3 0.0 1.8e-17 63.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EGD94148.1 - 1.2e-10 41.9 0.0 3.2e-10 40.6 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EGD94148.1 - 7.9e-08 32.2 0.0 1.4e-06 28.2 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EGD94148.1 - 3.2e-07 31.0 0.0 3.4e-06 27.7 0.0 2.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EGD94148.1 - 4.3e-07 30.5 0.0 8.3e-07 29.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_16 PF10294.9 EGD94148.1 - 0.0047 16.7 0.0 0.0075 16.0 0.0 1.2 1 0 0 1 1 1 1 Lysine methyltransferase PrmA PF06325.13 EGD94148.1 - 0.014 14.8 0.0 0.021 14.2 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 EGD94148.1 - 0.023 14.2 0.0 0.04 13.5 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_4 PF02390.17 EGD94148.1 - 0.029 13.8 0.0 0.081 12.4 0.0 1.7 2 0 0 2 2 2 0 Putative methyltransferase Methyltransf_2 PF00891.18 EGD94148.1 - 0.11 11.8 0.0 0.19 11.0 0.0 1.4 1 0 0 1 1 1 0 O-methyltransferase domain PRCC PF10253.9 EGD94148.1 - 1.5 9.6 10.2 2.9 8.6 10.2 1.6 1 0 0 1 1 1 0 Mitotic checkpoint regulator, MAD2B-interacting Med3 PF11593.8 EGD94148.1 - 5.6 6.0 14.7 8 5.5 14.7 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal DUF4620 PF15399.6 EGD94149.1 - 0.061 13.7 0.1 0.092 13.1 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4620) ABC_membrane PF00664.23 EGD94150.1 - 2.7e-89 299.5 27.9 3.9e-48 164.5 10.0 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EGD94150.1 - 1.8e-60 203.4 0.0 4.5e-29 101.7 0.0 2.5 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EGD94150.1 - 1.4e-15 57.4 5.7 1.6e-05 24.5 0.0 4.4 3 1 0 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EGD94150.1 - 1e-08 34.8 1.5 0.0012 18.5 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 EGD94150.1 - 3.3e-07 30.8 0.1 0.0049 17.3 0.0 3.2 2 2 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.6 EGD94150.1 - 5.1e-07 30.0 3.8 0.0098 16.2 0.3 4.1 2 2 0 2 2 2 2 AAA domain AAA_25 PF13481.6 EGD94150.1 - 7.5e-06 25.6 0.1 0.059 12.9 0.0 3.1 3 0 0 3 3 3 2 AAA domain RsgA_GTPase PF03193.16 EGD94150.1 - 1.2e-05 25.3 0.1 0.27 11.1 0.0 3.1 3 0 0 3 3 3 2 RsgA GTPase AAA_23 PF13476.6 EGD94150.1 - 1.3e-05 25.8 0.5 0.0077 16.7 0.1 2.5 2 0 0 2 2 2 1 AAA domain AAA_21 PF13304.6 EGD94150.1 - 1.6e-05 24.8 5.7 0.35 10.6 0.2 4.4 5 0 0 5 5 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_18 PF13238.6 EGD94150.1 - 0.00015 22.4 0.1 0.82 10.2 0.1 2.6 2 0 0 2 2 2 2 AAA domain ABC_ATPase PF09818.9 EGD94150.1 - 0.00049 19.0 3.1 0.12 11.2 0.8 3.4 3 0 0 3 3 3 1 Predicted ATPase of the ABC class AAA_15 PF13175.6 EGD94150.1 - 0.0018 18.0 1.7 1.3 8.6 0.1 2.2 2 0 0 2 2 2 2 AAA ATPase domain AAA_33 PF13671.6 EGD94150.1 - 0.0031 17.7 0.8 1.5 9.0 0.1 2.6 2 0 0 2 2 2 1 AAA domain SbcCD_C PF13558.6 EGD94150.1 - 0.0046 17.2 0.1 1.1 9.6 0.0 3.3 2 1 0 2 2 2 1 Putative exonuclease SbcCD, C subunit ATPase PF06745.13 EGD94150.1 - 0.0067 15.8 0.2 3.5 6.9 0.0 2.7 2 0 0 2 2 2 1 KaiC DUF3987 PF13148.6 EGD94150.1 - 0.0088 15.1 0.1 3.5 6.5 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF3987) MMR_HSR1 PF01926.23 EGD94150.1 - 0.01 15.9 1.4 2.5 8.2 0.1 2.9 2 1 0 2 2 2 0 50S ribosome-binding GTPase AAA_5 PF07728.14 EGD94150.1 - 0.011 15.7 0.2 1 9.4 0.0 2.6 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) APS_kinase PF01583.20 EGD94150.1 - 0.012 15.5 1.1 6.5 6.6 0.0 3.1 3 0 0 3 3 3 0 Adenylylsulphate kinase DUF87 PF01935.17 EGD94150.1 - 0.015 15.4 1.8 0.92 9.5 0.1 3.0 3 0 0 3 3 3 0 Helicase HerA, central domain IstB_IS21 PF01695.17 EGD94150.1 - 0.017 14.9 1.0 5.9 6.6 0.0 3.8 4 0 0 4 4 4 0 IstB-like ATP binding protein AAA PF00004.29 EGD94150.1 - 0.02 15.3 0.0 1.3 9.5 0.0 3.3 2 2 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 EGD94150.1 - 0.021 15.2 0.1 15 6.1 0.0 2.8 2 0 0 2 2 2 0 RNA helicase AAA_24 PF13479.6 EGD94150.1 - 0.023 14.5 0.7 2.2 8.0 0.0 2.7 3 0 0 3 3 3 0 AAA domain G-alpha PF00503.20 EGD94150.1 - 0.047 12.8 0.1 0.69 9.0 0.0 2.1 2 0 0 2 2 2 0 G-protein alpha subunit AAA_30 PF13604.6 EGD94150.1 - 0.056 13.1 2.3 11 5.7 0.1 3.4 4 0 0 4 4 4 0 AAA domain AAA_7 PF12775.7 EGD94150.1 - 0.083 12.4 0.0 10 5.6 0.0 2.5 2 0 0 2 2 2 0 P-loop containing dynein motor region NACHT PF05729.12 EGD94150.1 - 0.09 12.7 0.3 35 4.3 0.1 3.4 3 0 0 3 3 3 0 NACHT domain IspD PF01128.19 EGD94150.1 - 0.11 12.2 0.2 0.23 11.2 0.2 1.4 1 0 0 1 1 1 0 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase Cytidylate_kin PF02224.18 EGD94150.1 - 0.11 12.1 0.1 1.7 8.3 0.2 2.4 2 0 0 2 2 2 0 Cytidylate kinase FtsK_SpoIIIE PF01580.18 EGD94150.1 - 0.13 11.6 0.0 20 4.5 0.0 2.5 2 0 0 2 2 2 0 FtsK/SpoIIIE family Zeta_toxin PF06414.12 EGD94150.1 - 0.17 11.1 0.1 14 4.9 0.0 2.7 2 0 0 2 2 2 0 Zeta toxin Guanylate_kin PF00625.21 EGD94150.1 - 0.18 11.4 0.0 11 5.7 0.0 2.3 2 0 0 2 2 2 0 Guanylate kinase AcrZ PF10766.9 EGD94150.1 - 0.4 10.3 2.8 0.38 10.3 0.1 2.3 2 0 0 2 2 2 0 Multidrug efflux pump-associated protein AcrZ MFS_1 PF07690.16 EGD94151.1 - 2.8e-30 105.4 48.6 2.8e-30 105.4 48.6 2.4 2 1 0 2 2 2 1 Major Facilitator Superfamily p450 PF00067.22 EGD94152.1 - 6.7e-45 153.7 0.0 8.1e-45 153.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Ric8 PF10165.9 EGD94154.1 - 7e-130 434.1 0.1 8.2e-130 433.9 0.1 1.0 1 0 0 1 1 1 1 Guanine nucleotide exchange factor synembryn Polysacc_synt_4 PF04669.13 EGD94155.1 - 3.2e-22 79.0 0.8 9.1e-21 74.3 0.8 2.0 1 1 0 1 1 1 1 Polysaccharide biosynthesis Sugar_tr PF00083.24 EGD94156.1 - 9e-141 469.8 15.3 1e-140 469.6 15.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EGD94156.1 - 8.9e-28 97.2 26.2 2.1e-24 86.2 12.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily BT1 PF03092.16 EGD94156.1 - 0.00075 17.8 0.7 0.27 9.4 0.0 2.3 2 0 0 2 2 2 2 BT1 family UPF0014 PF03649.13 EGD94156.1 - 3.7 6.8 9.1 0.32 10.3 2.8 2.5 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0014) Glyco_hydro_25 PF01183.20 EGD94157.1 - 4.4e-40 137.8 0.0 5.1e-40 137.5 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 25 Rif1_N PF12231.8 EGD94158.1 - 7.8e-127 423.3 0.2 1.4e-126 422.5 0.2 1.4 1 0 0 1 1 1 1 Rap1-interacting factor 1 N terminal RhoGEF67_u2 PF16614.5 EGD94158.1 - 0.043 13.9 0.0 0.18 11.8 0.0 2.1 1 0 0 1 1 1 0 Unstructured region two on RhoGEF 6 and 7 DUF5538 PF17692.1 EGD94158.1 - 0.28 11.3 4.1 0.27 11.3 1.0 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5538) Aldose_epim PF01263.20 EGD94160.1 - 8e-29 100.9 0.0 9.6e-29 100.6 0.0 1.0 1 0 0 1 1 1 1 Aldose 1-epimerase BclA_C PF18573.1 EGD94160.1 - 0.046 13.6 0.3 0.099 12.6 0.1 1.6 2 0 0 2 2 2 0 BclA C-terminal domain MFS_1 PF07690.16 EGD94161.1 - 5.7e-24 84.7 27.4 5.7e-24 84.7 27.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily PHO4 PF01384.20 EGD94161.1 - 8.9 5.2 11.2 0.17 10.9 2.5 2.2 2 0 0 2 2 2 0 Phosphate transporter family DAHP_synth_2 PF01474.16 EGD94163.1 - 5.1e-205 681.1 0.0 5.7e-205 680.9 0.0 1.0 1 0 0 1 1 1 1 Class-II DAHP synthetase family PLA2_B PF01735.18 EGD94165.1 - 5.6e-195 648.4 0.3 6.5e-195 648.2 0.3 1.0 1 0 0 1 1 1 1 Lysophospholipase catalytic domain EphA2_TM PF14575.6 EGD94167.1 - 0.074 13.9 0.5 0.2 12.5 0.0 2.0 2 1 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Neur_chan_memb PF02932.16 EGD94167.1 - 0.16 12.0 6.7 1.2 9.2 6.7 2.2 1 1 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region SP_C-Propep PF08999.10 EGD94167.1 - 0.58 10.0 3.5 1.1 9.1 3.5 1.4 1 0 0 1 1 1 0 Surfactant protein C, N terminal propeptide adh_short_C2 PF13561.6 EGD94169.1 - 7.5e-60 202.4 0.3 8.6e-60 202.2 0.3 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EGD94169.1 - 1.6e-50 171.3 1.0 2.1e-50 170.9 1.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EGD94169.1 - 3.4e-16 59.7 0.2 4.5e-16 59.3 0.2 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EGD94169.1 - 0.0016 17.9 0.4 0.0026 17.2 0.4 1.3 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EGD94169.1 - 0.0021 17.5 0.1 0.0038 16.7 0.0 1.5 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase GGACT PF06094.12 EGD94170.1 - 2.6e-15 57.1 0.2 3.1e-15 56.8 0.2 1.1 1 0 0 1 1 1 1 Gamma-glutamyl cyclotransferase, AIG2-like Piwi PF02171.17 EGD94171.1 - 8.1e-73 245.3 0.0 1.2e-72 244.8 0.0 1.2 1 0 0 1 1 1 1 Piwi domain ArgoN PF16486.5 EGD94171.1 - 1.7e-16 61.1 0.0 3e-16 60.3 0.0 1.4 1 0 0 1 1 1 1 N-terminal domain of argonaute ArgoL1 PF08699.10 EGD94171.1 - 1.7e-12 46.8 0.1 5.5e-12 45.2 0.1 1.9 1 0 0 1 1 1 1 Argonaute linker 1 domain ArgoL2 PF16488.5 EGD94171.1 - 1.1e-07 32.1 0.0 3.4e-07 30.5 0.0 1.9 1 0 0 1 1 1 1 Argonaute linker 2 domain PAZ PF02170.22 EGD94171.1 - 1.9e-06 27.7 0.0 4.2e-06 26.6 0.0 1.6 1 0 0 1 1 1 1 PAZ domain ArgoMid PF16487.5 EGD94171.1 - 0.032 14.5 0.0 0.1 12.9 0.0 1.9 1 1 0 1 1 1 0 Mid domain of argonaute Ribophorin_II PF05817.14 EGD94173.1 - 1.3e-29 103.3 0.0 1.6e-29 103.0 0.0 1.1 1 0 0 1 1 1 1 Oligosaccharyltransferase subunit Ribophorin II PufQ PF05398.11 EGD94173.1 - 0.02 15.0 0.9 0.58 10.3 0.1 2.4 2 0 0 2 2 2 0 PufQ cytochrome subunit ORC6 PF05460.13 EGD94174.1 - 0.14 11.4 4.2 0.17 11.1 4.2 1.1 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) EVE PF01878.18 EGD94176.1 - 4.6e-46 156.4 1.9 6.1e-46 156.0 0.1 1.9 2 0 0 2 2 2 1 EVE domain DUF4551 PF15087.6 EGD94176.1 - 2.1 7.1 10.3 2.9 6.6 10.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Methyltransf_PK PF05891.12 EGD94177.1 - 3.8e-66 222.7 0.0 6.2e-66 222.1 0.0 1.3 1 1 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Methyltransf_2 PF00891.18 EGD94177.1 - 5.2e-08 32.4 0.1 1.3e-07 31.2 0.1 1.7 1 1 0 1 1 1 1 O-methyltransferase domain Methyltransf_25 PF13649.6 EGD94177.1 - 4.6e-06 27.2 0.0 1.4e-05 25.7 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EGD94177.1 - 0.00015 22.3 0.0 0.00035 21.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EGD94177.1 - 0.0016 19.2 0.0 0.0044 17.7 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Bin3 PF06859.12 EGD94177.1 - 0.027 15.1 0.0 0.045 14.4 0.0 1.3 1 0 0 1 1 1 0 Bicoid-interacting protein 3 (Bin3) Sec23_helical PF04815.15 EGD94177.1 - 0.027 14.3 0.1 0.46 10.3 0.1 2.1 1 1 0 1 1 1 0 Sec23/Sec24 helical domain Aldedh PF00171.22 EGD94178.1 - 2.3e-182 606.6 3.2 2.6e-182 606.5 3.2 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.11 EGD94178.1 - 0.00087 18.8 0.0 0.0037 16.7 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF1487) GAIN PF16489.5 EGD94178.1 - 0.085 12.3 0.1 0.15 11.4 0.1 1.3 1 0 0 1 1 1 0 GPCR-Autoproteolysis INducing (GAIN) domain bZIP_2 PF07716.15 EGD94181.1 - 3.1e-05 23.9 10.4 5.2e-05 23.3 10.4 1.3 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.21 EGD94181.1 - 5.8 7.1 11.5 13 6.0 11.5 1.5 1 1 0 1 1 1 0 bZIP transcription factor His_Phos_2 PF00328.22 EGD94183.1 - 3.3e-65 220.9 0.0 3.8e-65 220.7 0.0 1.0 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) AhpC-TSA PF00578.21 EGD94185.1 - 4.9e-14 52.3 0.1 1.4e-07 31.4 0.0 2.3 1 1 1 2 2 2 2 AhpC/TSA family 1-cysPrx_C PF10417.9 EGD94185.1 - 6e-09 35.6 0.1 1.1e-08 34.7 0.1 1.4 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin Kelch_3 PF13415.6 EGD94186.1 - 2e-16 59.8 9.3 3.5e-10 39.9 0.0 5.8 6 0 0 6 6 6 3 Galactose oxidase, central domain Kelch_4 PF13418.6 EGD94186.1 - 4e-14 52.3 0.5 0.00019 21.3 0.0 5.2 4 1 0 4 4 4 2 Galactose oxidase, central domain Kelch_6 PF13964.6 EGD94186.1 - 3.7e-13 49.2 0.7 0.067 13.5 0.0 5.6 5 0 0 5 5 5 4 Kelch motif Kelch_1 PF01344.25 EGD94186.1 - 2.6e-11 42.9 0.0 0.03 13.9 0.0 4.1 3 1 0 3 3 3 3 Kelch motif Kelch_5 PF13854.6 EGD94186.1 - 3.5e-09 36.4 1.7 0.0086 16.0 0.0 4.0 3 1 0 3 3 3 2 Kelch motif Kelch_2 PF07646.15 EGD94186.1 - 3e-05 23.8 8.7 0.0027 17.6 0.0 5.2 6 0 0 6 6 6 1 Kelch motif mRNA_triPase PF02940.15 EGD94187.1 - 5.5e-31 108.0 0.0 4.9e-18 65.6 0.0 2.3 1 1 1 2 2 2 2 mRNA capping enzyme, beta chain WD40 PF00400.32 EGD94188.1 - 2.5e-14 53.4 4.2 5.4e-05 23.9 0.0 4.9 4 0 0 4 4 4 3 WD domain, G-beta repeat TFIIA PF03153.13 EGD94188.1 - 4.1 7.3 31.2 9.3 6.1 31.2 1.6 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CTP_transf_like PF01467.26 EGD94189.1 - 0.017 15.3 2.1 0.44 10.7 0.3 2.4 2 1 0 2 2 2 0 Cytidylyltransferase-like F-box PF00646.33 EGD94192.1 - 0.12 12.3 1.5 0.28 11.1 0.1 2.3 2 0 0 2 2 2 0 F-box domain Zn_clus PF00172.18 EGD94193.1 - 2.7e-09 37.0 6.6 2.7e-09 37.0 6.6 2.3 3 0 0 3 3 3 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 EGD94193.1 - 2e-05 23.6 0.2 2.7e-05 23.2 0.2 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain UbiA PF01040.18 EGD94194.1 - 1.3e-56 191.7 17.0 1.3e-56 191.7 17.0 1.7 2 0 0 2 2 2 1 UbiA prenyltransferase family PQ-loop PF04193.14 EGD94195.1 - 4.7e-19 67.9 13.8 1.9e-12 46.7 1.6 3.2 3 0 0 3 3 3 2 PQ loop repeat Med8 PF10232.9 EGD94196.1 - 3.3e-61 206.9 1.0 4.6e-61 206.4 1.0 1.2 1 0 0 1 1 1 1 Mediator of RNA polymerase II transcription complex subunit 8 BSP_II PF05432.11 EGD94196.1 - 0.045 13.4 2.3 0.061 13.0 2.3 1.1 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) TMEM154 PF15102.6 EGD94197.1 - 0.18 11.7 0.0 0.32 10.9 0.0 1.3 1 0 0 1 1 1 0 TMEM154 protein family DUF3136 PF11334.8 EGD94200.1 - 0.13 12.1 0.0 0.26 11.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3136) FAD_binding_4 PF01565.23 EGD94201.1 - 1e-21 77.1 0.3 1.8e-21 76.3 0.3 1.4 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EGD94201.1 - 0.019 15.1 0.0 0.14 12.3 0.0 2.4 3 0 0 3 3 3 0 Berberine and berberine like Peptidase_S9 PF00326.21 EGD94202.1 - 0.038 13.5 2.6 0.17 11.3 0.0 2.5 3 0 0 3 3 3 0 Prolyl oligopeptidase family Abhydrolase_1 PF00561.20 EGD94202.1 - 0.11 12.1 0.3 0.3 10.7 0.3 1.7 1 1 0 1 1 1 0 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EGD94202.1 - 0.15 11.3 0.0 0.43 9.8 0.0 1.7 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Peptidase_S15 PF02129.18 EGD94202.1 - 0.15 11.7 0.0 0.31 10.6 0.0 1.5 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) TMF_TATA_bd PF12325.8 EGD94203.1 - 0.0005 20.3 6.6 0.0005 20.3 6.6 4.1 3 2 1 4 4 4 1 TATA element modulatory factor 1 TATA binding ABC_tran_CTD PF16326.5 EGD94203.1 - 0.022 15.0 4.7 0.022 15.0 4.7 4.1 4 1 1 5 5 5 0 ABC transporter C-terminal domain FlgN PF05130.12 EGD94203.1 - 0.036 14.6 20.2 0.54 10.8 2.3 3.6 3 1 1 4 4 4 0 FlgN protein ESCRT-II PF05871.12 EGD94203.1 - 0.043 14.1 1.1 0.13 12.5 0.8 1.8 1 1 0 1 1 1 0 ESCRT-II complex subunit TolA_bind_tri PF16331.5 EGD94203.1 - 0.07 13.2 11.2 0.11 12.6 4.8 3.1 2 0 0 2 2 2 0 TolA binding protein trimerisation Spc7 PF08317.11 EGD94203.1 - 0.071 12.0 18.8 0.14 11.0 7.7 2.4 2 0 0 2 2 2 0 Spc7 kinetochore protein DNA_repr_REX1B PF14966.6 EGD94203.1 - 0.13 13.0 5.4 0.052 14.2 1.7 2.3 2 1 0 2 2 2 0 DNA repair REX1-B CorA PF01544.18 EGD94203.1 - 0.14 11.4 4.5 0.045 13.1 0.6 2.1 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein DUF465 PF04325.13 EGD94203.1 - 0.25 11.4 6.9 1.5 8.9 4.4 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF465) Fez1 PF06818.15 EGD94203.1 - 0.35 11.3 22.7 0.93 9.9 3.8 2.5 3 0 0 3 3 2 0 Fez1 SKA2 PF16740.5 EGD94203.1 - 1.1 9.1 13.6 0.029 14.1 1.9 3.5 3 1 0 3 3 3 0 Spindle and kinetochore-associated protein 2 Seryl_tRNA_N PF02403.22 EGD94203.1 - 1.5 9.1 20.3 0.36 11.1 6.3 4.0 3 2 1 4 4 4 0 Seryl-tRNA synthetase N-terminal domain DUF1515 PF07439.11 EGD94203.1 - 1.7 8.7 10.0 0.1 12.6 2.8 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF1515) CENP-H PF05837.12 EGD94203.1 - 2.3 8.7 21.5 0.61 10.5 5.7 4.2 3 2 0 3 3 3 0 Centromere protein H (CENP-H) COG2 PF06148.11 EGD94203.1 - 2.6 8.2 11.9 0.1 12.7 2.4 2.9 3 1 0 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 APG6_N PF17675.1 EGD94203.1 - 3.1 8.3 29.1 0.47 11.0 9.3 3.9 2 1 1 3 3 3 0 Apg6 coiled-coil region Prominin PF05478.11 EGD94203.1 - 4.4 5.1 12.8 0.27 9.1 4.9 2.0 1 1 1 2 2 2 0 Prominin Allexi_40kDa PF05549.11 EGD94203.1 - 4.9 6.6 12.7 0.19 11.2 1.4 3.0 3 0 0 3 3 3 0 Allexivirus 40kDa protein DUF2730 PF10805.8 EGD94203.1 - 5 7.3 8.4 0.58 10.3 2.7 2.3 2 1 1 3 3 3 0 Protein of unknown function (DUF2730) DUF4140 PF13600.6 EGD94203.1 - 6.1 7.4 14.2 1.6 9.2 3.0 4.1 3 2 0 3 3 3 0 N-terminal domain of unknown function (DUF4140) Osmo_CC PF08946.10 EGD94203.1 - 7.3 6.9 11.0 1.3 9.4 2.7 3.0 3 0 0 3 3 2 0 Osmosensory transporter coiled coil FAA_hydro_N_2 PF18288.1 EGD94203.1 - 9.3 6.8 6.9 64 4.1 0.0 3.9 5 1 0 5 5 4 0 Fumarylacetoacetase N-terminal domain 2 RPN2_C PF18004.1 EGD94204.1 - 1.7e-54 184.0 5.4 1.7e-54 184.0 5.4 2.3 2 0 0 2 2 2 1 26S proteasome regulatory subunit RPN2 C-terminal domain PC_rep PF01851.22 EGD94204.1 - 3.4e-32 109.2 25.2 7.6e-10 38.7 0.0 8.8 8 0 0 8 8 8 7 Proteasome/cyclosome repeat HEAT_2 PF13646.6 EGD94204.1 - 3.8e-22 78.5 0.5 6.5e-16 58.5 0.0 3.8 3 1 1 4 4 3 2 HEAT repeats HEAT_EZ PF13513.6 EGD94204.1 - 8.3e-09 35.8 0.1 0.019 15.5 0.0 4.0 3 0 0 3 3 3 2 HEAT-like repeat HEAT PF02985.22 EGD94204.1 - 3.7e-06 26.7 0.0 1.8 9.0 0.0 4.8 4 0 0 4 4 4 2 HEAT repeat Cnd1 PF12717.7 EGD94204.1 - 0.0023 18.0 0.0 0.17 11.9 0.0 2.8 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 HEAT_PBS PF03130.16 EGD94204.1 - 0.0077 16.8 2.3 1.1 10.2 0.0 3.9 3 0 0 3 3 3 1 PBS lyase HEAT-like repeat UBN_AB PF14075.6 EGD94204.1 - 0.0084 15.8 1.0 0.021 14.5 1.0 1.6 1 0 0 1 1 1 1 Ubinuclein conserved middle domain GCIP PF13324.6 EGD94204.1 - 0.071 12.7 5.3 0.15 11.7 5.3 1.4 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting RRN3 PF05327.11 EGD94204.1 - 3.5 6.1 7.6 6 5.3 7.6 1.3 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Vfa1 PF08432.10 EGD94204.1 - 9.4 6.5 14.6 0.34 11.2 3.2 2.3 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 Acyl-CoA_dh_1 PF00441.24 EGD94205.1 - 2.2e-42 144.8 0.3 3.2e-42 144.3 0.3 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 EGD94205.1 - 2.5e-21 75.7 0.1 4.1e-21 75.0 0.1 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 EGD94205.1 - 5.5e-20 72.1 0.0 1.1e-19 71.1 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Cyt-b5 PF00173.28 EGD94205.1 - 6.2e-15 55.1 0.3 1.2e-14 54.1 0.3 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Acyl-CoA_dh_2 PF08028.11 EGD94205.1 - 6e-10 39.5 0.0 9.9e-10 38.8 0.0 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Spt5-NGN PF03439.13 EGD94206.1 - 8.2e-22 76.9 0.0 1.5e-21 76.1 0.0 1.4 1 0 0 1 1 1 1 Early transcription elongation factor of RNA pol II, NGN section CTD PF12815.7 EGD94206.1 - 9.9e-19 67.7 18.2 9.9e-19 67.7 18.2 3.8 1 1 2 3 3 3 2 Spt5 C-terminal nonapeptide repeat binding Spt4 Spt5_N PF11942.8 EGD94206.1 - 2e-17 64.0 10.7 2e-17 64.0 10.7 3.8 2 1 1 3 3 3 1 Spt5 transcription elongation factor, acidic N-terminal KOW PF00467.29 EGD94206.1 - 1.2e-05 25.1 13.6 0.0033 17.3 1.6 4.3 4 0 0 4 4 4 2 KOW motif DUF3912 PF13051.6 EGD94206.1 - 0.00066 19.9 7.6 0.0093 16.2 0.1 3.1 3 0 0 3 3 3 2 Protein of unknown function (DUF3912) DUF1506 PF07405.11 EGD94206.1 - 0.21 11.8 0.2 0.97 9.6 0.2 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1506) CS PF04969.16 EGD94207.1 - 2.6e-07 31.5 0.0 3.2e-07 31.3 0.0 1.1 1 0 0 1 1 1 1 CS domain Anoctamin PF04547.12 EGD94208.1 - 2e-109 366.4 10.3 2.6e-109 366.1 10.3 1.1 1 0 0 1 1 1 1 Calcium-activated chloride channel Pex2_Pex12 PF04757.14 EGD94208.1 - 0.025 14.2 0.0 0.025 14.2 0.0 2.3 3 0 0 3 3 3 0 Pex2 / Pex12 amino terminal region YMF19 PF02326.15 EGD94208.1 - 0.66 10.8 3.7 15 6.5 0.8 3.5 3 0 0 3 3 3 0 Plant ATP synthase F0 ERM PF00769.19 EGD94209.1 - 3.8e-05 23.6 23.6 8.9e-05 22.4 23.6 1.6 1 0 0 1 1 1 1 Ezrin/radixin/moesin family APH PF01636.23 EGD94209.1 - 8.4e-05 22.6 0.1 8.4e-05 22.6 0.1 3.3 2 1 1 3 3 3 1 Phosphotransferase enzyme family HSDR_N_2 PF13588.6 EGD94209.1 - 0.0013 18.7 0.0 1.2 9.1 0.0 2.6 2 0 0 2 2 2 2 Type I restriction enzyme R protein N terminus (HSDR_N) Pkinase PF00069.25 EGD94209.1 - 0.0031 16.9 0.0 0.0059 16.0 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Choline_kinase PF01633.20 EGD94209.1 - 0.0064 16.1 0.5 0.013 15.0 0.0 1.7 2 0 0 2 2 2 1 Choline/ethanolamine kinase K_channel_TID PF07941.11 EGD94209.1 - 0.13 12.7 0.2 0.13 12.7 0.2 3.2 3 0 0 3 3 3 0 Potassium channel Kv1.4 tandem inactivation domain Golgin_A5 PF09787.9 EGD94209.1 - 1.9 7.9 25.0 3 7.2 25.0 1.2 1 0 0 1 1 1 0 Golgin subfamily A member 5 Atg14 PF10186.9 EGD94209.1 - 2.8 6.9 13.3 4.4 6.3 13.3 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF874 PF05917.11 EGD94209.1 - 5.1 6.0 9.3 7.8 5.4 9.3 1.2 1 0 0 1 1 1 0 Helicobacter pylori protein of unknown function (DUF874) APG6_N PF17675.1 EGD94209.1 - 5.8 7.4 31.6 13 6.3 31.6 1.5 1 0 0 1 1 1 0 Apg6 coiled-coil region Actin PF00022.19 EGD94211.1 - 7.8e-55 186.1 0.0 2.1e-30 105.7 0.0 2.4 1 1 1 2 2 2 2 Actin DASH_Dad4 PF08650.10 EGD94212.1 - 4.4e-31 106.7 5.6 5e-31 106.5 5.6 1.0 1 0 0 1 1 1 1 DASH complex subunit Dad4 GM_CSF PF01109.17 EGD94212.1 - 0.0099 16.0 0.4 0.013 15.7 0.4 1.2 1 0 0 1 1 1 1 Granulocyte-macrophage colony-stimulating factor DASH_Dad1 PF08649.10 EGD94212.1 - 0.053 13.7 2.5 0.081 13.1 2.5 1.3 1 1 0 1 1 1 0 DASH complex subunit Dad1 DUF2443 PF10398.9 EGD94212.1 - 0.054 13.5 0.2 0.09 12.8 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2443) Biotin_carb_C PF02785.19 EGD94212.1 - 0.1 12.7 0.0 0.12 12.5 0.0 1.1 1 0 0 1 1 1 0 Biotin carboxylase C-terminal domain YL1_C PF08265.11 EGD94213.1 - 5.6e-17 61.2 0.3 9e-17 60.5 0.3 1.3 1 0 0 1 1 1 1 YL1 nuclear protein C-terminal domain Gag_p12 PF01141.18 EGD94213.1 - 0.35 11.2 3.0 0.25 11.7 0.8 2.0 2 0 0 2 2 2 0 Gag polyprotein, inner coat protein p12 Got1 PF04178.12 EGD94214.1 - 3.3e-14 53.3 13.9 4.4e-14 52.9 13.9 1.1 1 0 0 1 1 1 1 Got1/Sft2-like family DUF373 PF04123.13 EGD94214.1 - 7.8 5.8 6.0 3.9 6.8 3.7 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF373) Profilin PF00235.19 EGD94215.1 - 7e-47 158.9 0.0 7.8e-47 158.7 0.0 1.0 1 0 0 1 1 1 1 Profilin XTBD PF11952.8 EGD94217.1 - 0.17 11.7 0.0 0.32 10.8 0.0 1.4 1 0 0 1 1 1 0 XRN-Two Binding Domain, XTBD Sec63 PF02889.16 EGD94218.1 - 2.2e-128 426.9 0.0 4.3e-77 258.8 0.1 2.3 2 0 0 2 2 2 2 Sec63 Brl domain DEAD PF00270.29 EGD94218.1 - 3.4e-53 180.0 1.2 2.4e-26 92.6 1.5 2.8 3 0 0 3 3 3 2 DEAD/DEAH box helicase ResIII PF04851.15 EGD94218.1 - 6.2e-23 81.7 0.0 4.1e-11 43.2 0.0 2.5 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EGD94218.1 - 7.1e-16 58.5 0.1 4.2e-07 30.3 0.0 4.4 4 2 0 4 4 4 2 Helicase conserved C-terminal domain AAA_22 PF13401.6 EGD94218.1 - 1.2e-07 32.0 2.0 0.0034 17.7 0.0 3.7 3 1 0 3 3 2 2 AAA domain AAA_30 PF13604.6 EGD94218.1 - 2.3e-07 30.7 0.3 0.0012 18.6 0.6 2.5 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.6 EGD94218.1 - 2.6e-05 24.6 1.6 0.002 18.5 1.2 2.6 2 0 0 2 2 2 1 AAA domain T2SSE PF00437.20 EGD94218.1 - 0.0024 17.0 0.0 0.8 8.7 0.0 2.5 2 0 0 2 2 2 2 Type II/IV secretion system protein Helicase_PWI PF18149.1 EGD94218.1 - 0.0032 17.6 0.0 0.008 16.3 0.0 1.6 1 0 0 1 1 1 1 N-terminal helicase PWI domain PhoH PF02562.16 EGD94218.1 - 0.011 15.2 0.0 0.7 9.3 0.0 2.5 2 0 0 2 2 2 0 PhoH-like protein IstB_IS21 PF01695.17 EGD94218.1 - 0.054 13.2 0.1 3.8 7.2 0.0 3.1 3 0 0 3 3 3 0 IstB-like ATP binding protein AAA_7 PF12775.7 EGD94218.1 - 0.072 12.6 0.1 6.3 6.3 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region DEK_C PF08766.11 EGD94218.1 - 0.075 13.0 0.1 0.21 11.6 0.1 1.7 1 0 0 1 1 1 0 DEK C terminal domain FtsK_SpoIIIE PF01580.18 EGD94218.1 - 0.24 10.7 0.8 0.83 9.0 0.8 1.9 1 1 0 1 1 1 0 FtsK/SpoIIIE family TniB PF05621.11 EGD94218.1 - 0.25 10.8 3.9 31 3.9 0.4 3.7 3 1 0 4 4 4 0 Bacterial TniB protein Synaptobrevin PF00957.21 EGD94219.1 - 8.7e-14 51.1 0.2 1.3e-13 50.5 0.2 1.2 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.6 EGD94219.1 - 1.6e-11 44.1 0.0 3e-11 43.2 0.0 1.4 1 0 0 1 1 1 1 Regulated-SNARE-like domain Amidohydro_2 PF04909.14 EGD94219.1 - 0.044 13.6 0.0 0.066 13.0 0.0 1.4 1 1 0 1 1 1 0 Amidohydrolase Pkinase PF00069.25 EGD94221.1 - 1.3e-25 90.2 0.0 2.2e-24 86.3 0.0 2.2 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD94221.1 - 4.4e-05 22.9 0.3 0.05 12.9 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase MFS_1 PF07690.16 EGD94222.1 - 5.9e-25 87.9 69.1 1.8e-18 66.6 42.8 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 EGD94222.1 - 6.8e-08 31.5 14.1 1.5e-05 23.8 5.5 3.0 1 1 0 2 2 2 2 MFS/sugar transport protein CDH-cyt PF16010.5 EGD94222.1 - 0.027 14.2 1.0 0.047 13.4 1.0 1.3 1 0 0 1 1 1 0 Cytochrome domain of cellobiose dehydrogenase MFS_4 PF06779.14 EGD94222.1 - 0.91 8.7 31.9 0.81 8.9 17.3 2.5 1 1 0 2 2 2 0 Uncharacterised MFS-type transporter YbfB DUF5337 PF17272.2 EGD94222.1 - 5.1 7.0 8.7 0.28 11.0 0.8 3.1 3 0 0 3 3 3 0 Family of unknown function (DUF5337) Ras PF00071.22 EGD94223.1 - 7.6e-36 123.2 0.0 8.7e-35 119.7 0.0 2.0 1 1 0 1 1 1 1 Ras family Roc PF08477.13 EGD94223.1 - 3.1e-28 98.4 0.0 4.7e-28 97.8 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EGD94223.1 - 2.6e-10 40.0 0.0 4e-10 39.4 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EGD94223.1 - 0.00026 21.1 0.0 0.0004 20.4 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.6 EGD94223.1 - 0.0008 19.8 0.1 0.0017 18.8 0.0 1.6 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 EGD94223.1 - 0.011 16.0 0.0 0.034 14.4 0.0 1.8 1 1 0 1 1 1 0 AAA domain SRPRB PF09439.10 EGD94223.1 - 0.012 15.1 0.0 0.019 14.4 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit PduV-EutP PF10662.9 EGD94223.1 - 0.056 13.2 0.0 0.63 9.8 0.0 2.1 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Gtr1_RagA PF04670.12 EGD94223.1 - 0.072 12.4 0.0 0.1 11.9 0.0 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region NACHT PF05729.12 EGD94223.1 - 0.085 12.8 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 NACHT domain AAA_14 PF13173.6 EGD94223.1 - 0.099 12.7 0.0 0.17 11.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 EGD94223.1 - 0.15 11.9 0.0 0.31 10.9 0.0 1.6 1 0 0 1 1 1 0 RsgA GTPase AAA_24 PF13479.6 EGD94223.1 - 0.16 11.6 0.0 0.26 11.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 EGD94223.1 - 0.2 11.2 0.1 0.3 10.6 0.1 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region FMN_dh PF01070.18 EGD94224.1 - 7.2e-121 403.5 0.2 8.5e-121 403.2 0.2 1.0 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Cyt-b5 PF00173.28 EGD94224.1 - 3.9e-20 71.8 0.0 8.1e-20 70.8 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Glu_synthase PF01645.17 EGD94224.1 - 4.9e-06 25.9 0.1 7.8e-06 25.3 0.1 1.3 1 0 0 1 1 1 1 Conserved region in glutamate synthase NMO PF03060.15 EGD94224.1 - 1.4e-05 24.7 0.5 3.4e-05 23.4 0.3 1.7 1 1 1 2 2 2 1 Nitronate monooxygenase IMPDH PF00478.25 EGD94224.1 - 0.00065 18.8 2.4 0.0019 17.3 0.1 2.6 2 1 1 3 3 3 1 IMP dehydrogenase / GMP reductase domain His_biosynth PF00977.21 EGD94224.1 - 0.042 13.3 0.0 2.6 7.4 0.0 2.3 2 0 0 2 2 2 0 Histidine biosynthesis protein Metallophos PF00149.28 EGD94225.1 - 6.6e-16 59.4 3.0 8.6e-16 59.0 3.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EGD94225.1 - 8e-08 32.6 0.9 1.4e-06 28.7 0.9 2.1 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain MutL PF13941.6 EGD94225.1 - 0.018 13.6 0.0 0.027 13.1 0.0 1.1 1 0 0 1 1 1 0 MutL protein Pkinase PF00069.25 EGD94226.1 - 2.8e-40 138.3 0.0 7.8e-23 81.2 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EGD94226.1 - 6e-13 48.7 0.1 2.2e-09 37.0 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase_fungal PF17667.1 EGD94226.1 - 0.11 11.3 2.3 0.074 11.8 0.3 1.7 1 1 1 2 2 2 0 Fungal protein kinase Herpes_DNAp_acc PF04929.12 EGD94226.1 - 0.46 9.4 2.6 0.8 8.6 2.6 1.3 1 0 0 1 1 1 0 Herpes DNA replication accessory factor Bud13 PF09736.9 EGD94227.1 - 4.2e-49 166.7 1.6 4.2e-49 166.7 1.6 3.0 2 1 1 3 3 3 1 Pre-mRNA-splicing factor of RES complex Nop16 PF09420.10 EGD94227.1 - 2.9 7.9 14.2 0.026 14.6 5.7 1.9 2 1 0 2 2 2 0 Ribosome biogenesis protein Nop16 SPATIAL PF15256.6 EGD94227.1 - 7.3 6.9 9.9 0.71 10.2 4.7 1.9 2 0 0 2 2 2 0 SPATIAL DUF812 PF05667.11 EGD94228.1 - 0.016 14.1 0.2 0.019 13.9 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF812) Macoilin PF09726.9 EGD94228.1 - 0.045 12.3 1.0 0.057 12.0 1.0 1.1 1 0 0 1 1 1 0 Macoilin family DUF1192 PF06698.11 EGD94228.1 - 0.11 12.6 1.5 0.21 11.7 0.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) DNA_binding_1 PF01035.20 EGD94229.1 - 3.6e-26 91.1 0.0 4.7e-26 90.7 0.0 1.1 1 0 0 1 1 1 1 6-O-methylguanine DNA methyltransferase, DNA binding domain PHINT_rpt PF14882.6 EGD94229.1 - 0.13 12.5 0.2 0.28 11.5 0.2 1.5 1 0 0 1 1 1 0 Phage-integrase repeat unit Fungal_trans_2 PF11951.8 EGD94233.1 - 2.1e-96 323.1 1.6 2.4e-96 322.9 1.6 1.0 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EGD94233.1 - 8.9e-11 41.7 10.0 8.9e-11 41.7 10.0 1.7 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Brr6_like_C_C PF10104.9 EGD94234.1 - 1.6e-47 160.6 0.7 2.2e-47 160.2 0.7 1.2 1 0 0 1 1 1 1 Di-sulfide bridge nucleocytoplasmic transport domain DUF5423 PF17461.2 EGD94234.1 - 0.43 9.4 6.6 0.7 8.7 6.6 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5423) AA_permease PF00324.21 EGD94235.1 - 1.7e-118 396.2 51.1 2.1e-118 395.9 51.1 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EGD94235.1 - 2.6e-30 105.6 52.2 3.4e-30 105.2 52.2 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EGD94236.1 - 2.3e-63 214.5 49.7 2.8e-63 214.2 49.7 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EGD94236.1 - 1.3e-10 40.5 44.8 1.7e-10 40.2 44.8 1.1 1 0 0 1 1 1 1 Amino acid permease Acetyltransf_1 PF00583.25 EGD94238.1 - 1.2e-17 64.2 0.0 1.4e-17 64.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EGD94238.1 - 2.1e-08 34.4 0.0 3.1e-08 33.9 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EGD94238.1 - 7.1e-08 32.3 0.0 1.1e-07 31.7 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_10 PF13673.7 EGD94238.1 - 5.8e-07 29.5 0.0 9.2e-07 28.8 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 EGD94238.1 - 1.5e-06 28.9 0.0 1.8e-06 28.7 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_15 PF17013.5 EGD94238.1 - 0.012 15.1 0.0 0.012 15.1 0.0 1.2 1 0 0 1 1 1 0 Putative acetyl-transferase Acetyltransf_CG PF14542.6 EGD94238.1 - 0.025 14.7 0.0 0.043 14.0 0.0 1.3 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase Acetyltransf_4 PF13420.7 EGD94238.1 - 0.058 13.5 0.0 0.19 11.9 0.0 1.6 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain OB_aCoA_assoc PF01796.17 EGD94238.1 - 0.17 11.9 0.1 0.33 11.0 0.1 1.4 1 0 0 1 1 1 0 DUF35 OB-fold domain, acyl-CoA-associated GRIP PF01465.20 EGD94239.1 - 7.9e-15 54.5 0.2 1.7e-14 53.5 0.2 1.6 1 0 0 1 1 1 1 GRIP domain CALCOCO1 PF07888.11 EGD94239.1 - 6.3e-06 25.3 138.0 0.0013 17.7 23.9 5.8 3 1 2 5 5 5 3 Calcium binding and coiled-coil domain (CALCOCO1) like Baculo_PEP_C PF04513.12 EGD94239.1 - 0.00031 20.8 40.5 0.23 11.5 4.9 7.1 6 2 1 7 7 7 3 Baculovirus polyhedron envelope protein, PEP, C terminus GAS PF13851.6 EGD94239.1 - 0.0012 18.2 132.3 0.025 13.9 10.4 9.0 4 2 3 8 8 8 4 Growth-arrest specific micro-tubule binding Lebercilin PF15619.6 EGD94239.1 - 0.0015 18.2 12.6 0.0015 18.2 12.6 8.0 4 2 4 8 8 7 2 Ciliary protein causing Leber congenital amaurosis disease TMF_TATA_bd PF12325.8 EGD94239.1 - 0.002 18.3 10.3 0.002 18.3 10.3 11.5 6 3 7 13 13 12 3 TATA element modulatory factor 1 TATA binding Spc7 PF08317.11 EGD94239.1 - 0.0038 16.2 137.7 0.039 12.8 17.9 8.0 3 2 4 7 7 7 4 Spc7 kinetochore protein HMMR_N PF15905.5 EGD94239.1 - 0.0089 15.5 134.4 0.18 11.2 24.3 8.5 3 2 5 8 8 8 4 Hyaluronan mediated motility receptor N-terminal CENP-F_leu_zip PF10473.9 EGD94239.1 - 0.011 15.7 147.8 0.022 14.8 13.6 9.8 3 2 7 10 10 10 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DHR10 PF18595.1 EGD94239.1 - 0.013 15.6 11.6 0.013 15.6 11.6 11.9 5 2 6 12 12 11 0 Designed helical repeat protein 10 domain TolA_bind_tri PF16331.5 EGD94239.1 - 0.12 12.5 0.1 0.12 12.5 0.1 11.3 7 4 3 10 10 10 0 TolA binding protein trimerisation MAD PF05557.13 EGD94239.1 - 0.15 10.3 127.5 0.0053 15.2 6.9 6.2 3 2 4 7 7 7 0 Mitotic checkpoint protein Bap31_Bap29_C PF18035.1 EGD94239.1 - 0.19 11.8 0.1 0.19 11.8 0.1 10.1 9 2 1 10 10 10 0 Bap31/Bap29 cytoplasmic coiled-coil domain Myosin_tail_1 PF01576.19 EGD94239.1 - 0.3 8.9 144.4 0.014 13.3 18.2 3.8 3 1 0 3 3 3 0 Myosin tail VGPC1_C PF16799.5 EGD94239.1 - 0.57 10.2 16.2 0.24 11.4 0.8 4.7 4 0 0 4 4 4 0 C-terminal membrane-localisation domain of ion-channel, VCN1 Filament PF00038.21 EGD94239.1 - 0.7 9.4 125.1 0.25 10.9 47.3 6.9 3 2 4 7 7 6 0 Intermediate filament protein FPP PF05911.11 EGD94239.1 - 2.6 6.1 134.6 0.43 8.7 19.0 6.6 1 1 6 7 7 7 0 Filament-like plant protein, long coiled-coil EzrA PF06160.12 EGD94239.1 - 2.6 6.1 104.7 0.13 10.4 44.8 7.1 3 2 2 5 5 5 0 Septation ring formation regulator, EzrA DUF641 PF04859.12 EGD94239.1 - 2.7 8.4 105.4 0.037 14.3 9.1 10.5 6 3 4 10 10 9 0 Plant protein of unknown function (DUF641) AAA_13 PF13166.6 EGD94239.1 - 3.6 6.1 105.4 0.54 8.8 18.8 6.2 3 1 2 5 5 5 0 AAA domain FAA_hydro_N_2 PF18288.1 EGD94239.1 - 7.1 7.1 9.4 0.75 10.3 0.4 4.3 3 1 1 4 4 3 0 Fumarylacetoacetase N-terminal domain 2 zinc_ribbon_10 PF10058.9 EGD94240.1 - 1.1e-18 66.6 0.1 1.8e-18 66.0 0.1 1.3 1 0 0 1 1 1 1 Predicted integral membrane zinc-ribbon metal-binding protein cNMP_binding PF00027.29 EGD94241.1 - 3.2e-29 100.8 2.9 2e-19 69.5 0.0 5.5 5 1 0 5 5 5 3 Cyclic nucleotide-binding domain Patatin PF01734.22 EGD94241.1 - 5.9e-17 62.5 10.7 6.2e-16 59.2 7.8 2.9 2 1 0 2 2 2 1 Patatin-like phospholipase DAO PF01266.24 EGD94242.1 - 6.1e-30 105.0 0.0 8.3e-30 104.6 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Sacchrp_dh_NADP PF03435.18 EGD94242.1 - 0.00011 22.4 0.0 0.00051 20.3 0.0 2.0 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain NAD_binding_9 PF13454.6 EGD94242.1 - 0.0017 18.4 0.0 0.065 13.2 0.0 2.4 2 0 0 2 2 2 1 FAD-NAD(P)-binding NAD_binding_8 PF13450.6 EGD94242.1 - 0.0088 16.3 0.0 0.032 14.5 0.0 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.6 EGD94242.1 - 0.11 11.6 0.0 0.25 10.4 0.0 1.5 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) TrkA_N PF02254.18 EGD94242.1 - 0.13 12.6 0.0 0.23 11.7 0.0 1.4 1 0 0 1 1 1 0 TrkA-N domain Pyr_redox_2 PF07992.14 EGD94242.1 - 0.19 10.9 0.0 3.4 6.8 0.0 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Methyltransf_33 PF10017.9 EGD94243.1 - 7.8e-72 242.0 0.0 1e-71 241.6 0.0 1.1 1 0 0 1 1 1 1 Histidine-specific methyltransferase, SAM-dependent Fungal_trans_2 PF11951.8 EGD94244.1 - 2e-28 99.3 0.5 2.8e-28 98.8 0.5 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-C2H2 PF00096.26 EGD94245.1 - 2.1 9.0 9.9 2.9 8.5 0.5 2.8 2 1 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EGD94245.1 - 2.3 9.3 5.5 4.9 8.2 0.1 3.0 3 0 0 3 3 3 0 C2H2-type zinc finger HNH_2 PF13391.6 EGD94246.1 - 1.5e-06 28.2 0.2 2.8e-06 27.4 0.2 1.6 1 0 0 1 1 1 1 HNH endonuclease ISN1 PF06437.11 EGD94247.1 - 8.9e-195 647.3 0.0 1e-194 647.2 0.0 1.0 1 0 0 1 1 1 1 IMP-specific 5'-nucleotidase eIF-5a PF01287.20 EGD94247.1 - 0.028 14.5 0.0 0.079 13.1 0.0 1.8 1 0 0 1 1 1 0 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold Med17 PF10156.9 EGD94248.1 - 5.2e-99 332.0 1.6 8.5e-99 331.3 1.3 1.4 1 1 0 1 1 1 1 Subunit 17 of Mediator complex PFK PF00365.20 EGD94249.1 - 3.3e-192 636.9 0.1 1.4e-106 356.0 0.1 2.1 2 0 0 2 2 2 2 Phosphofructokinase DAGK_cat PF00781.24 EGD94249.1 - 0.043 13.4 0.1 0.17 11.5 0.1 2.0 1 0 0 1 1 1 0 Diacylglycerol kinase catalytic domain Glyco_hydro_76 PF03663.14 EGD94250.1 - 2e-160 534.3 7.6 2.3e-160 534.1 7.6 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 Glyco_hydro_88 PF07470.13 EGD94250.1 - 3.3e-05 23.1 8.1 0.0028 16.8 0.1 3.1 2 1 1 3 3 3 3 Glycosyl Hydrolase Family 88 MARVEL PF01284.23 EGD94251.1 - 1.2e-10 41.6 9.6 1.5e-10 41.2 9.6 1.1 1 0 0 1 1 1 1 Membrane-associating domain DUF4181 PF13789.6 EGD94251.1 - 0.029 14.6 2.8 0.033 14.5 1.3 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4181) RAC_head PF16717.5 EGD94252.1 - 7e-31 107.1 2.6 7e-31 107.1 2.6 2.8 2 1 0 2 2 2 1 Ribosome-associated complex head domain DnaJ PF00226.31 EGD94252.1 - 0.00014 21.9 0.1 0.00068 19.7 0.0 2.3 2 0 0 2 2 2 1 DnaJ domain RRM_1 PF00076.22 EGD94253.1 - 4e-10 39.4 0.0 7.6e-10 38.5 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EGD94253.1 - 0.0026 17.7 0.0 0.0043 17.0 0.0 1.3 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif RRM_occluded PF16842.5 EGD94253.1 - 0.057 13.3 0.0 0.098 12.5 0.0 1.3 1 0 0 1 1 1 0 Occluded RNA-recognition motif Sterol_MT_C PF08498.10 EGD94254.1 - 3.9e-28 97.6 0.2 6.5e-28 96.8 0.2 1.4 1 0 0 1 1 1 1 Sterol methyltransferase C-terminal Methyltransf_11 PF08241.12 EGD94254.1 - 3.3e-18 66.1 0.0 5.8e-18 65.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EGD94254.1 - 4.4e-18 65.8 0.0 8e-18 64.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EGD94254.1 - 1.5e-15 57.3 0.0 2.3e-15 56.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EGD94254.1 - 3.4e-11 43.3 0.0 5.6e-11 42.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 EGD94254.1 - 5e-11 42.4 0.0 7.8e-11 41.8 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_12 PF08242.12 EGD94254.1 - 9.5e-11 42.3 0.0 2.5e-10 41.0 0.0 1.8 2 0 0 2 2 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EGD94254.1 - 2.7e-09 36.7 0.0 4.3e-09 36.0 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family PCMT PF01135.19 EGD94254.1 - 0.0011 18.7 0.0 0.0019 18.0 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_15 PF09445.10 EGD94254.1 - 0.0012 18.4 0.0 0.0018 17.8 0.0 1.3 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase PrmA PF06325.13 EGD94254.1 - 0.0015 18.0 0.0 0.0026 17.2 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 EGD94254.1 - 0.0033 17.0 0.0 0.014 14.9 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_32 PF13679.6 EGD94254.1 - 0.0056 16.7 1.2 0.01 15.8 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_4 PF02390.17 EGD94254.1 - 0.0064 16.0 0.0 0.019 14.4 0.0 1.8 2 0 0 2 2 2 1 Putative methyltransferase RrnaAD PF00398.20 EGD94254.1 - 0.021 13.9 0.0 0.033 13.3 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase Methyltransf_2 PF00891.18 EGD94254.1 - 0.062 12.6 0.0 0.091 12.0 0.0 1.3 1 0 0 1 1 1 0 O-methyltransferase domain Methyltransf_24 PF13578.6 EGD94254.1 - 0.14 13.2 0.0 0.45 11.6 0.0 1.9 2 0 0 2 2 1 0 Methyltransferase domain zf-MYND PF01753.18 EGD94255.1 - 1.6e-07 31.3 10.6 1.6e-07 31.3 10.6 2.1 2 0 0 2 2 2 1 MYND finger zf-HIT PF04438.16 EGD94255.1 - 1.4 8.8 15.0 0.2 11.6 9.4 2.4 2 0 0 2 2 2 0 HIT zinc finger Peptidase_S8 PF00082.22 EGD94256.1 - 2.1e-18 66.7 15.3 5.8e-18 65.2 15.3 1.7 1 1 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 EGD94256.1 - 1.6e-14 54.3 0.0 2.7e-14 53.6 0.0 1.4 1 0 0 1 1 1 1 Peptidase inhibitor I9 MFS_1 PF07690.16 EGD94257.1 - 1.6e-43 149.0 53.3 1.8e-42 145.5 53.3 2.2 1 1 0 1 1 1 1 Major Facilitator Superfamily DUF3377 PF11857.8 EGD94257.1 - 0.043 13.7 0.1 0.043 13.7 0.1 3.2 4 1 1 5 5 5 0 Domain of unknown function (DUF3377) Strabismus PF06638.11 EGD94257.1 - 0.062 11.9 2.5 0.095 11.3 2.5 1.2 1 0 0 1 1 1 0 Strabismus protein Zn_clus PF00172.18 EGD94258.1 - 2e-08 34.2 9.3 3.7e-08 33.4 9.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Sulfatase PF00884.23 EGD94259.1 - 2.1e-51 175.2 0.0 7.7e-50 170.0 0.0 2.1 1 1 0 1 1 1 1 Sulfatase Choline_sulf_C PF12411.8 EGD94259.1 - 6.3e-21 73.9 0.1 4.7e-20 71.1 0.0 2.2 1 1 1 2 2 2 1 Choline sulfatase enzyme C terminal Phosphodiest PF01663.22 EGD94259.1 - 8.3e-08 32.2 0.0 5.4e-06 26.2 0.0 2.4 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase_C PF14707.6 EGD94259.1 - 0.038 14.7 0.0 0.1 13.3 0.0 1.8 1 0 0 1 1 1 0 C-terminal region of aryl-sulfatase DUF4976 PF16347.5 EGD94259.1 - 0.077 13.3 0.0 0.18 12.1 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4976) DUF229 PF02995.17 EGD94259.1 - 0.09 11.4 0.0 0.11 11.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF229) Amidohydro_1 PF01979.20 EGD94260.1 - 4.9e-72 243.1 0.0 5.8e-72 242.9 0.0 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 EGD94260.1 - 8.1e-09 35.5 1.0 4.3e-06 26.5 0.0 2.7 3 0 0 3 3 3 2 Amidohydrolase family A_deaminase PF00962.22 EGD94260.1 - 1e-05 25.1 0.0 1.7e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 Adenosine/AMP deaminase Toxin_29 PF08116.11 EGD94260.1 - 0.035 14.1 0.3 0.1 12.6 0.3 1.8 1 0 0 1 1 1 0 PhTx neurotoxin family tRNA_int_end_N2 PF12928.7 EGD94260.1 - 0.043 14.0 0.0 0.17 12.0 0.0 2.0 2 0 0 2 2 2 0 tRNA-splicing endonuclease subunit sen54 N-term DUF3466 PF11949.8 EGD94260.1 - 0.098 11.2 0.1 0.14 10.8 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3466) GDC-P PF02347.16 EGD94264.1 - 2.9e-171 570.0 0.0 7.5e-160 532.5 0.0 2.6 2 1 0 2 2 2 2 Glycine cleavage system P-protein Beta_elim_lyase PF01212.21 EGD94264.1 - 4.8e-07 29.3 0.2 1.8e-06 27.4 0.1 1.9 2 0 0 2 2 2 1 Beta-eliminating lyase Aminotran_5 PF00266.19 EGD94264.1 - 0.0014 17.7 0.1 0.0069 15.4 0.0 2.1 2 0 0 2 2 2 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 EGD94264.1 - 0.018 14.4 0.0 0.03 13.6 0.0 1.2 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family TMEM51 PF15345.6 EGD94265.1 - 3.7e-05 23.7 1.5 4.9e-05 23.3 0.0 1.9 2 1 1 3 3 3 1 Transmembrane protein 51 PRIMA1 PF16101.5 EGD94265.1 - 5.7 7.0 0.0 5.7 7.0 0.0 2.7 2 1 1 3 3 3 0 Proline-rich membrane anchor 1 Pyridoxal_deC PF00282.19 EGD94266.1 - 4.9e-105 351.3 0.0 5.7e-105 351.1 0.0 1.0 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Beta_elim_lyase PF01212.21 EGD94266.1 - 0.00027 20.3 0.0 0.00071 18.9 0.0 1.5 1 1 0 1 1 1 1 Beta-eliminating lyase Abhydrolase_6 PF12697.7 EGD94267.1 - 6.9e-14 53.0 0.2 8.1e-14 52.8 0.2 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family MBOAT_2 PF13813.6 EGD94268.1 - 2.4e-23 82.2 0.3 4.5e-23 81.3 0.3 1.5 1 0 0 1 1 1 1 Membrane bound O-acyl transferase family Glyco_hydro_65N PF03636.15 EGD94269.1 - 2.2e-36 125.6 0.0 3.6e-36 124.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 65, N-terminal domain Glyco_hydro_65m PF03632.15 EGD94269.1 - 6.6e-26 91.1 1.7 1.7e-20 73.2 0.2 2.2 1 1 1 2 2 2 2 Glycosyl hydrolase family 65 central catalytic domain Glyco_hydro_65C PF03633.15 EGD94269.1 - 0.00014 21.6 0.1 0.00043 20.1 0.1 1.9 1 0 0 1 1 1 1 Glycosyl hydrolase family 65, C-terminal domain SMC_Nse1 PF07574.13 EGD94270.1 - 1.5e-69 233.8 0.2 1.9e-69 233.5 0.2 1.1 1 0 0 1 1 1 1 Nse1 non-SMC component of SMC5-6 complex zf-RING-like PF08746.11 EGD94270.1 - 3.4e-12 46.5 9.9 7.4e-12 45.4 9.9 1.6 1 0 0 1 1 1 1 RING-like domain zf-RING_2 PF13639.6 EGD94270.1 - 0.0014 18.9 8.2 0.0024 18.2 8.2 1.4 1 0 0 1 1 1 1 Ring finger domain PaaX PF07848.12 EGD94270.1 - 0.0046 17.1 0.1 0.011 15.9 0.1 1.7 1 0 0 1 1 1 1 PaaX-like protein zf-ANAPC11 PF12861.7 EGD94270.1 - 0.01 15.9 2.1 0.019 15.0 2.1 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger AbiEi_4 PF13338.6 EGD94270.1 - 0.014 15.6 0.9 0.048 13.8 0.2 2.3 2 1 1 3 3 3 0 Transcriptional regulator, AbiEi antitoxin zf-rbx1 PF12678.7 EGD94270.1 - 0.096 13.0 5.3 0.19 12.0 5.3 1.5 1 0 0 1 1 1 0 RING-H2 zinc finger domain CtsR_C PF17727.1 EGD94270.1 - 0.1 12.8 0.0 3.1 8.0 0.0 2.8 3 0 0 3 3 3 0 CtsR C-terminal dimerization domain Baculo_IE-1 PF05290.11 EGD94270.1 - 0.67 9.9 4.4 1.5 8.8 3.6 1.8 2 0 0 2 2 2 0 Baculovirus immediate-early protein (IE-0) zf-HC5HC2H_2 PF13832.6 EGD94270.1 - 0.82 9.9 9.2 3.6 7.8 9.3 2.0 1 1 0 1 1 1 0 PHD-zinc-finger like domain zf-C3HC4_2 PF13923.6 EGD94270.1 - 0.96 9.4 7.3 1.7 8.5 7.3 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-HC5HC2H PF13771.6 EGD94270.1 - 1 9.7 11.0 3 8.2 9.8 2.1 1 1 1 2 2 2 0 PHD-like zinc-binding domain Zn_ribbon_17 PF17120.5 EGD94270.1 - 1.1 8.9 7.2 2 8.1 7.2 1.5 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-C3HC4 PF00097.25 EGD94270.1 - 1.8 8.5 8.0 3.6 7.5 8.0 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EGD94270.1 - 2.8 8.0 9.6 5.2 7.1 9.6 1.5 1 0 0 1 1 1 0 zinc-RING finger domain DAO PF01266.24 EGD94271.1 - 7.2e-44 150.8 0.6 8.3e-44 150.6 0.6 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 EGD94271.1 - 0.0053 17.3 0.0 0.048 14.2 0.1 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EGD94271.1 - 0.0087 16.3 0.0 0.02 15.1 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 EGD94271.1 - 0.0091 16.0 0.0 0.019 14.9 0.0 1.5 1 0 0 1 1 1 1 FAD-NAD(P)-binding Pyr_redox_2 PF07992.14 EGD94271.1 - 0.039 13.2 0.0 0.58 9.3 0.0 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase DJ-1_PfpI PF01965.24 EGD94272.1 - 1.6e-20 73.6 0.0 2.4e-20 73.0 0.0 1.2 1 0 0 1 1 1 1 DJ-1/PfpI family GATase PF00117.28 EGD94272.1 - 0.0009 19.1 0.0 0.0013 18.6 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferase class-I APH PF01636.23 EGD94273.1 - 9.3e-12 45.4 0.0 3.6e-07 30.4 0.0 2.4 2 0 0 2 2 2 2 Phosphotransferase enzyme family APH PF01636.23 EGD94274.1 - 9.1e-11 42.1 0.0 1.8e-10 41.2 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EGD94274.1 - 2.8e-05 23.8 0.0 4.3e-05 23.2 0.0 1.2 1 0 0 1 1 1 1 Choline/ethanolamine kinase Pkinase PF00069.25 EGD94274.1 - 0.00032 20.1 0.1 0.54 9.6 0.0 2.3 2 1 0 2 2 2 2 Protein kinase domain CBM_19 PF03427.13 EGD94274.1 - 0.025 14.5 0.2 0.081 12.9 0.0 1.8 2 0 0 2 2 2 0 Carbohydrate binding domain (family 19) Fructosamin_kin PF03881.14 EGD94274.1 - 0.043 13.0 0.0 7.8 5.6 0.0 2.1 2 0 0 2 2 2 0 Fructosamine kinase DUF1679 PF07914.11 EGD94274.1 - 0.09 11.6 0.1 2.5 6.8 0.1 2.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1679) AA_permease_2 PF13520.6 EGD94275.1 - 5.4e-71 239.6 31.2 6.9e-71 239.3 31.2 1.1 1 0 0 1 1 1 1 Amino acid permease DAP10 PF07213.11 EGD94275.1 - 0.03 14.3 1.6 0.72 9.8 0.4 2.6 2 0 0 2 2 2 0 DAP10 membrane protein adh_short PF00106.25 EGD94276.1 - 1.5e-40 138.8 0.0 1.9e-40 138.4 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EGD94276.1 - 7.4e-26 91.1 0.0 8.8e-26 90.9 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EGD94276.1 - 1.4e-08 34.9 0.0 1.9e-08 34.4 0.0 1.1 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 EGD94276.1 - 0.00016 21.6 0.1 0.00031 20.7 0.1 1.5 1 0 0 1 1 1 1 NAD(P)H-binding TrkA_N PF02254.18 EGD94276.1 - 0.00028 21.1 0.0 0.00048 20.4 0.0 1.4 1 0 0 1 1 1 1 TrkA-N domain Epimerase PF01370.21 EGD94276.1 - 0.00038 20.0 0.0 0.0037 16.7 0.0 2.1 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family NmrA PF05368.13 EGD94276.1 - 0.052 13.1 0.1 0.11 12.1 0.0 1.5 2 0 0 2 2 2 0 NmrA-like family 3Beta_HSD PF01073.19 EGD94276.1 - 0.055 12.5 0.0 0.098 11.6 0.0 1.3 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family PALP PF00291.25 EGD94276.1 - 0.14 11.6 0.0 0.19 11.1 0.0 1.2 1 0 0 1 1 1 0 Pyridoxal-phosphate dependent enzyme CBFD_NFYB_HMF PF00808.23 EGD94277.1 - 7.3e-19 67.8 0.6 1.2e-18 67.1 0.6 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EGD94277.1 - 4.7e-06 27.0 0.1 1.4e-05 25.5 0.0 1.7 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 TFIID-31kDa PF02291.15 EGD94277.1 - 0.029 14.4 0.0 0.043 13.9 0.0 1.2 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 EGD94277.1 - 0.078 13.0 0.0 0.11 12.5 0.0 1.2 1 0 0 1 1 1 0 Bromodomain associated YolD PF08863.10 EGD94277.1 - 0.3 11.2 4.4 0.17 12.0 2.2 1.6 2 0 0 2 2 2 0 YolD-like protein Actin PF00022.19 EGD94278.1 - 3.6e-21 75.2 0.0 1.1e-17 63.7 0.0 3.1 3 0 0 3 3 3 3 Actin Bystin PF05291.11 EGD94279.1 - 1e-130 435.3 0.0 1.4e-130 434.9 0.0 1.1 1 0 0 1 1 1 1 Bystin Amidase PF01425.21 EGD94281.1 - 7.9e-118 394.3 0.1 1.6e-117 393.3 0.1 1.4 1 1 0 1 1 1 1 Amidase DUF3347 PF11827.8 EGD94282.1 - 9.1 6.4 8.7 14 5.8 4.8 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3347) BTRD1 PF17660.1 EGD94283.1 - 4.6e-73 240.9 12.7 4e-15 55.4 0.1 5.0 5 0 0 5 5 5 5 Bacterial tandem repeat domain 1 bZIP_2 PF07716.15 EGD94284.1 - 3.5e-08 33.4 14.1 3.5e-08 33.4 14.1 2.6 1 1 1 2 2 2 2 Basic region leucine zipper bZIP_1 PF00170.21 EGD94284.1 - 1.6e-06 28.1 17.9 8.5e-06 25.8 17.9 2.2 1 1 0 1 1 1 1 bZIP transcription factor bZIP_Maf PF03131.17 EGD94284.1 - 0.013 16.0 12.0 0.013 16.0 12.0 1.9 2 0 0 2 2 2 0 bZIP Maf transcription factor FPP PF05911.11 EGD94284.1 - 0.02 13.1 6.0 0.029 12.6 6.0 1.2 1 0 0 1 1 1 0 Filament-like plant protein, long coiled-coil SOGA PF11365.8 EGD94284.1 - 0.024 15.7 0.8 0.024 15.7 0.8 2.7 2 1 1 3 3 3 0 Protein SOGA Striatin PF08232.12 EGD94284.1 - 0.028 15.0 9.3 0.034 14.7 7.8 2.0 1 1 0 1 1 1 0 Striatin family DLIC PF05783.11 EGD94284.1 - 0.057 12.2 5.0 0.093 11.5 5.0 1.2 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) APG6_N PF17675.1 EGD94284.1 - 0.29 11.6 13.1 0.55 10.7 13.1 1.4 1 0 0 1 1 1 0 Apg6 coiled-coil region ATF7IP_BD PF16788.5 EGD94284.1 - 0.41 10.7 18.1 0.12 12.4 12.1 2.3 2 0 0 2 2 2 0 ATF-interacting protein binding domain APH PF01636.23 EGD94286.1 - 3.6e-08 33.6 0.0 1.5e-07 31.6 0.0 2.0 2 1 0 2 2 2 1 Phosphotransferase enzyme family DUF1679 PF07914.11 EGD94286.1 - 0.00071 18.6 0.0 0.017 14.0 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF1679) Mvb12 PF09452.10 EGD94286.1 - 0.022 15.2 1.8 0.041 14.3 1.0 2.0 1 1 0 1 1 1 0 ESCRT-I subunit Mvb12 ADH_zinc_N PF00107.26 EGD94287.1 - 9.6e-15 54.7 0.0 1.9e-14 53.8 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EGD94287.1 - 0.019 14.8 0.0 0.047 13.6 0.0 1.6 2 0 0 2 2 2 0 Alcohol dehydrogenase GroES-like domain MSV199 PF10553.9 EGD94287.1 - 0.12 12.6 0.0 0.24 11.6 0.0 1.4 1 0 0 1 1 1 0 MSV199 domain Metallophos PF00149.28 EGD94288.1 - 1.4e-09 38.7 0.2 3.9e-09 37.3 0.2 1.7 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase 5_nucleotid_C PF02872.18 EGD94288.1 - 0.002 18.4 0.0 0.0043 17.3 0.0 1.5 1 0 0 1 1 1 1 5'-nucleotidase, C-terminal domain Transket_pyr PF02779.24 EGD94289.1 - 4.6e-47 160.0 0.0 8.5e-47 159.1 0.0 1.5 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 EGD94289.1 - 3.3e-35 120.7 0.1 8.6e-35 119.3 0.1 1.8 1 0 0 1 1 1 1 Transketolase, C-terminal domain Glyco_hydro_43 PF04616.14 EGD94290.1 - 6.1e-60 203.0 3.6 7e-60 202.8 3.6 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 Glyco_hydro_32N PF00251.20 EGD94290.1 - 0.2 11.2 1.6 0.35 10.4 1.6 1.5 1 1 0 1 1 1 0 Glycosyl hydrolases family 32 N-terminal domain zf-C2H2 PF00096.26 EGD94291.1 - 0.0032 17.8 1.2 0.0071 16.7 1.2 1.6 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-met PF12874.7 EGD94291.1 - 0.006 16.9 0.3 0.011 16.2 0.3 1.4 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EGD94291.1 - 0.015 15.6 2.3 0.025 14.9 2.3 1.4 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding zf-LYAR PF08790.11 EGD94291.1 - 0.08 12.9 0.1 0.14 12.0 0.1 1.5 1 0 0 1 1 1 0 LYAR-type C2HC zinc finger zf-C2H2_4 PF13894.6 EGD94291.1 - 0.085 13.7 0.5 0.21 12.5 0.5 1.7 1 0 0 1 1 1 0 C2H2-type zinc finger DUF1691 PF07950.11 EGD94292.1 - 2.3e-41 140.8 5.7 5.6e-33 113.9 4.6 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF1691) Phage_holin_3_6 PF07332.11 EGD94292.1 - 0.88 9.6 4.1 0.56 10.3 0.3 2.3 2 1 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III TRM PF02005.16 EGD94293.1 - 2.2e-108 362.8 0.0 1.7e-93 313.8 0.0 2.1 2 0 0 2 2 2 2 N2,N2-dimethylguanosine tRNA methyltransferase Methyltransf_25 PF13649.6 EGD94293.1 - 0.014 16.1 0.0 0.037 14.7 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.6 EGD94293.1 - 0.032 14.0 0.0 0.1 12.4 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase domain Met_10 PF02475.16 EGD94293.1 - 0.034 13.9 0.0 0.059 13.1 0.0 1.3 1 0 0 1 1 1 0 Met-10+ like-protein DUF2067 PF09840.9 EGD94293.1 - 0.11 12.1 0.0 0.29 10.7 0.0 1.6 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2067) MTS PF05175.14 EGD94293.1 - 0.16 11.5 0.0 0.39 10.3 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase small domain FAS_I_H PF18314.1 EGD94294.1 - 9.7e-77 257.2 0.6 3.9e-76 255.2 0.0 2.2 2 0 0 2 2 2 1 Fatty acid synthase type I helical domain Fas_alpha_ACP PF18325.1 EGD94294.1 - 1.8e-75 252.7 0.2 4.5e-75 251.4 0.0 1.8 2 0 0 2 2 2 1 Fatty acid synthase subunit alpha Acyl carrier domain ketoacyl-synt PF00109.26 EGD94294.1 - 6.3e-21 75.1 0.0 1.2e-20 74.2 0.0 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain ACPS PF01648.20 EGD94294.1 - 1.8e-18 66.8 0.1 4e-18 65.6 0.1 1.6 1 0 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily Ketoacyl-synt_C PF02801.22 EGD94294.1 - 2.8e-12 46.7 0.0 7.1e-12 45.4 0.0 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain adh_short PF00106.25 EGD94294.1 - 6.7e-05 22.4 0.0 0.00013 21.5 0.0 1.5 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EGD94294.1 - 0.003 17.2 0.0 0.0066 16.0 0.0 1.6 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EGD94294.1 - 0.0033 17.3 0.0 0.0077 16.2 0.0 1.6 1 0 0 1 1 1 1 KR domain DUF1729 PF08354.10 EGD94295.1 - 1.3e-141 471.7 0.0 2e-141 471.0 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1729) Acyl_transf_1 PF00698.21 EGD94295.1 - 4.9e-94 315.4 0.0 7.7e-91 304.9 0.0 3.7 5 0 0 5 5 5 2 Acyl transferase domain FAS_meander PF17951.1 EGD94295.1 - 6.8e-54 181.6 0.0 1.6e-53 180.4 0.0 1.7 1 0 0 1 1 1 1 Fatty acid synthase meander beta sheet domain MaoC_dehydratas PF01575.19 EGD94295.1 - 7e-39 132.2 0.1 2.8e-38 130.3 0.0 2.0 2 0 0 2 2 2 1 MaoC like domain SAT PF16073.5 EGD94295.1 - 1.5e-37 129.7 0.1 5.2e-37 127.9 0.0 1.9 2 0 0 2 2 2 1 Starter unit:ACP transacylase in aflatoxin biosynthesis FAS_N PF17828.1 EGD94295.1 - 4.8e-37 126.8 0.0 1.2e-36 125.5 0.0 1.7 1 0 0 1 1 1 1 N-terminal domain in fatty acid synthase subunit beta MaoC_dehydrat_N PF13452.6 EGD94295.1 - 1.3e-21 77.1 0.0 3.8e-21 75.6 0.0 1.8 1 0 0 1 1 1 1 N-terminal half of MaoC dehydratase Gamma-thionin PF00304.20 EGD94296.1 - 0.0039 17.4 7.4 0.005 17.1 7.4 1.2 1 0 0 1 1 1 1 Gamma-thionin family SLR1-BP PF07333.12 EGD94296.1 - 0.0045 17.4 3.4 0.0054 17.2 3.4 1.1 1 0 0 1 1 1 1 S locus-related glycoprotein 1 binding pollen coat protein (SLR1-BP) Myticin-prepro PF10690.9 EGD94296.1 - 0.031 14.5 3.5 0.035 14.4 3.5 1.0 1 0 0 1 1 1 0 Myticin pre-proprotein from the mussel Defensin_2 PF01097.18 EGD94296.1 - 0.93 9.5 10.8 1.5 8.8 10.8 1.4 1 1 0 1 1 1 0 Arthropod defensin His_Phos_2 PF00328.22 EGD94297.1 - 8.4e-107 357.8 0.0 1.1e-106 357.5 0.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) PPIP5K2_N PF18086.1 EGD94297.1 - 9.4e-38 128.3 0.0 2e-37 127.2 0.0 1.6 1 0 0 1 1 1 1 Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain RimK PF08443.11 EGD94297.1 - 0.00011 21.9 0.0 0.00023 20.8 0.0 1.4 1 0 0 1 1 1 1 RimK-like ATP-grasp domain Utp21 PF04192.12 EGD94298.1 - 1.1e-81 273.8 0.1 1.6e-81 273.2 0.1 1.2 1 0 0 1 1 1 1 Utp21 specific WD40 associated putative domain WD40 PF00400.32 EGD94298.1 - 7.3e-13 48.8 27.5 0.00026 21.7 0.4 10.6 11 1 0 11 11 11 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EGD94298.1 - 3.6e-12 46.4 0.5 0.0021 18.3 0.0 7.4 3 2 5 8 8 8 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EGD94298.1 - 1.1e-05 24.3 0.0 0.64 8.6 0.0 3.3 3 0 0 3 3 3 3 Nucleoporin Nup120/160 Lgl_C PF08596.10 EGD94298.1 - 0.15 10.8 0.2 0.43 9.2 0.0 1.9 2 0 0 2 2 2 0 Lethal giant larvae(Lgl) like, C-terminal FeoB_associated PF12669.7 EGD94299.1 - 0.13 12.6 0.8 0.22 11.9 0.8 1.2 1 0 0 1 1 1 0 FeoB-associated Cys-rich membrane protein DUF383 PF04063.14 EGD94300.1 - 3.4e-69 232.3 0.0 3.5e-68 229.1 0.0 2.5 3 0 0 3 3 3 1 Domain of unknown function (DUF383) DUF384 PF04064.13 EGD94300.1 - 7.5e-22 76.9 2.4 1.7e-21 75.8 1.0 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF384) Peptidase_C50 PF03568.17 EGD94300.1 - 0.00096 18.4 0.0 0.0021 17.2 0.0 1.4 1 1 0 1 1 1 1 Peptidase family C50 Rep-A_N PF04057.12 EGD94301.1 - 0.0016 18.4 0.0 0.0029 17.6 0.0 1.4 1 0 0 1 1 1 1 Replication factor-A protein 1, N-terminal domain BRCA-2_OB1 PF09103.10 EGD94301.1 - 0.0068 16.4 0.0 0.013 15.5 0.0 1.4 1 0 0 1 1 1 1 BRCA2, oligonucleotide/oligosaccharide-binding, domain 1 TPP1 PF10341.9 EGD94301.1 - 0.029 14.3 0.0 0.066 13.2 0.0 1.6 1 0 0 1 1 1 0 Shelterin complex subunit, TPP1/ACD PAP_assoc PF03828.19 EGD94302.1 - 2.2e-07 31.0 0.0 5.4e-07 29.7 0.0 1.6 1 0 0 1 1 1 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.23 EGD94302.1 - 0.045 14.1 0.0 0.092 13.1 0.0 1.4 1 0 0 1 1 1 0 Nucleotidyltransferase domain TFIIF_alpha PF05793.12 EGD94303.1 - 1e-08 34.2 10.6 1e-08 34.2 10.6 3.5 1 1 2 3 3 3 3 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) IBR PF01485.21 EGD94304.1 - 4.1e-11 42.9 43.8 2.1e-07 31.1 10.7 3.5 3 1 0 3 3 3 2 IBR domain, a half RING-finger domain XPG_I_2 PF12813.7 EGD94305.1 - 4.6e-75 252.3 0.0 6.4e-75 251.8 0.0 1.2 1 0 0 1 1 1 1 XPG domain containing 5_3_exonuc_N PF02739.16 EGD94305.1 - 0.032 14.1 0.0 0.35 10.8 0.0 2.5 3 0 0 3 3 3 0 5'-3' exonuclease, N-terminal resolvase-like domain Inositol_P PF00459.25 EGD94306.1 - 1.9e-68 230.9 0.0 2.4e-68 230.6 0.0 1.0 1 0 0 1 1 1 1 Inositol monophosphatase family DUF676 PF05057.14 EGD94307.1 - 2.2e-37 128.7 0.0 1e-35 123.3 0.0 2.8 1 1 0 1 1 1 1 Putative serine esterase (DUF676) DAGK_cat PF00781.24 EGD94307.1 - 8.9e-12 44.7 0.0 2.1e-11 43.5 0.0 1.6 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain Lipase_3 PF01764.25 EGD94307.1 - 0.18 11.7 0.0 0.43 10.5 0.0 1.5 1 0 0 1 1 1 0 Lipase (class 3) Fcf1 PF04900.12 EGD94308.1 - 8.5e-36 122.3 1.5 8.6e-36 122.3 0.3 1.6 2 0 0 2 2 2 1 Fcf1 PIN_9 PF18477.1 EGD94308.1 - 6e-13 49.1 0.3 2.8e-12 47.0 0.0 1.9 2 0 0 2 2 2 1 PIN like domain Ras PF00071.22 EGD94310.1 - 2.1e-32 111.9 0.0 2.7e-32 111.6 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EGD94310.1 - 2.7e-07 30.8 0.0 4.7e-07 30.0 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EGD94310.1 - 6.5e-05 22.5 0.0 7.6e-05 22.2 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family FeoB_N PF02421.18 EGD94310.1 - 0.028 14.0 0.4 0.041 13.4 0.0 1.5 2 0 0 2 2 2 0 Ferrous iron transport protein B NCA2 PF08637.10 EGD94311.1 - 3.3e-102 341.6 0.5 1.2e-101 339.8 0.1 2.0 2 0 0 2 2 2 1 ATP synthase regulation protein NCA2 FANCF PF11107.8 EGD94311.1 - 0.0077 15.5 0.0 0.022 14.0 0.0 1.8 2 1 0 2 2 2 1 Fanconi anemia group F protein (FANCF) Radial_spoke PF04712.12 EGD94311.1 - 0.1 11.5 0.5 0.15 11.0 0.5 1.1 1 0 0 1 1 1 0 Radial spokehead-like protein PBP_sp32 PF07222.12 EGD94311.1 - 0.11 12.0 1.3 0.19 11.2 1.3 1.3 1 0 0 1 1 1 0 Proacrosin binding protein sp32 Ribosomal_60s PF00428.19 EGD94311.1 - 1.3 9.6 8.8 3 8.5 8.8 1.5 1 0 0 1 1 1 0 60s Acidic ribosomal protein FA_hydroxylase PF04116.13 EGD94312.1 - 6.4e-26 91.3 16.9 6.4e-26 91.3 16.9 1.8 2 1 0 2 2 2 1 Fatty acid hydroxylase superfamily AAA PF00004.29 EGD94313.1 - 1.5e-57 193.7 0.0 2.3e-40 138.1 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EGD94313.1 - 5.1e-13 48.6 0.6 4.8e-07 29.5 0.1 2.8 2 0 0 2 2 2 2 AAA+ lid domain AAA_16 PF13191.6 EGD94313.1 - 5.7e-08 33.3 2.5 0.1 13.0 0.0 4.1 2 2 0 3 3 3 2 AAA ATPase domain AAA_22 PF13401.6 EGD94313.1 - 7.7e-06 26.2 0.5 0.19 12.0 0.0 3.5 2 1 0 2 2 2 2 AAA domain AAA_5 PF07728.14 EGD94313.1 - 1.1e-05 25.4 0.5 0.0048 16.9 0.1 3.4 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) Bac_DnaA PF00308.18 EGD94313.1 - 1.3e-05 25.1 0.0 0.0056 16.5 0.0 3.0 2 1 0 2 2 2 1 Bacterial dnaA protein RuvB_N PF05496.12 EGD94313.1 - 0.00011 21.9 0.0 0.032 14.0 0.0 2.7 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain Rad17 PF03215.15 EGD94313.1 - 0.00013 22.0 0.0 0.002 18.1 0.0 2.2 2 0 0 2 2 2 1 Rad17 P-loop domain TIP49 PF06068.13 EGD94313.1 - 0.00014 21.2 0.3 0.0023 17.2 0.1 2.2 2 0 0 2 2 2 1 TIP49 P-loop domain RNA_helicase PF00910.22 EGD94313.1 - 0.00014 22.2 0.0 0.24 11.8 0.0 2.7 2 0 0 2 2 2 2 RNA helicase AAA_7 PF12775.7 EGD94313.1 - 0.00021 20.9 0.3 0.6 9.6 0.0 2.5 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA_25 PF13481.6 EGD94313.1 - 0.00024 20.7 0.3 6.2 6.3 0.0 4.0 3 1 1 4 4 4 1 AAA domain AAA_28 PF13521.6 EGD94313.1 - 0.00026 21.3 0.0 0.63 10.3 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_2 PF07724.14 EGD94313.1 - 0.0005 20.2 0.0 0.0014 18.7 0.0 1.8 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) CDC48_N PF02359.18 EGD94313.1 - 0.00072 19.7 0.0 0.067 13.4 0.0 2.6 2 0 0 2 2 2 1 Cell division protein 48 (CDC48), N-terminal domain AAA_14 PF13173.6 EGD94313.1 - 0.00088 19.3 0.0 0.34 10.9 0.0 2.6 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 EGD94313.1 - 0.0014 18.4 0.0 1.4 8.6 0.0 2.3 2 0 0 2 2 2 2 IstB-like ATP binding protein Mg_chelatase PF01078.21 EGD94313.1 - 0.0026 17.2 2.0 0.011 15.1 0.1 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI DUF815 PF05673.13 EGD94313.1 - 0.0034 16.6 0.0 2.3 7.3 0.0 2.6 3 0 0 3 3 3 2 Protein of unknown function (DUF815) NACHT PF05729.12 EGD94313.1 - 0.0068 16.3 0.3 5.7 6.8 0.1 2.9 3 0 0 3 3 3 1 NACHT domain AAA_30 PF13604.6 EGD94313.1 - 0.023 14.4 0.5 6.2 6.5 0.1 2.9 3 0 0 3 3 3 0 AAA domain ATPase_2 PF01637.18 EGD94313.1 - 0.024 14.5 0.5 5.8 6.7 0.1 3.1 2 1 1 3 3 3 0 ATPase domain predominantly from Archaea MCM PF00493.23 EGD94313.1 - 0.027 13.6 0.1 5.8 5.9 0.0 2.3 2 0 0 2 2 2 0 MCM P-loop domain AAA_24 PF13479.6 EGD94313.1 - 0.033 13.9 0.2 5.6 6.6 0.3 2.5 2 0 0 2 2 2 0 AAA domain Vps4_C PF09336.10 EGD94313.1 - 0.035 14.1 0.2 6.9 6.8 0.1 2.6 2 0 0 2 2 2 0 Vps4 C terminal oligomerisation domain AAA_29 PF13555.6 EGD94313.1 - 0.13 12.1 0.2 1.1 9.1 0.1 2.2 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_3 PF07726.11 EGD94313.1 - 0.16 11.9 0.0 0.36 10.7 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) HNH_2 PF13391.6 EGD94314.1 - 1.6e-14 53.7 0.1 3.3e-14 52.8 0.1 1.6 1 0 0 1 1 1 1 HNH endonuclease RRM_1 PF00076.22 EGD94315.1 - 7.7e-14 51.3 0.0 1.2e-13 50.7 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EGD94315.1 - 0.00041 19.9 0.0 0.00065 19.3 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EGD94315.1 - 0.11 12.3 0.0 0.2 11.6 0.0 1.3 1 0 0 1 1 1 0 Occluded RNA-recognition motif PI3_PI4_kinase PF00454.27 EGD94316.1 - 1.1e-51 176.1 0.0 2.3e-51 175.0 0.0 1.6 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase UME PF08064.13 EGD94316.1 - 2.6e-32 110.8 0.3 1.4e-31 108.4 0.0 2.6 2 0 0 2 2 2 1 UME (NUC010) domain FAT PF02259.23 EGD94316.1 - 1.9e-31 109.6 0.2 9.6e-31 107.3 0.0 2.2 2 0 0 2 2 2 1 FAT domain FATC PF02260.20 EGD94316.1 - 2.1e-13 49.8 0.0 4.2e-13 48.9 0.0 1.6 1 0 0 1 1 1 1 FATC domain TPR_19 PF14559.6 EGD94316.1 - 0.12 12.9 0.1 24 5.6 0.0 3.1 2 0 0 2 2 2 0 Tetratricopeptide repeat dCMP_cyt_deam_1 PF00383.23 EGD94317.1 - 8.4e-27 93.0 0.1 1.1e-26 92.7 0.1 1.1 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 EGD94317.1 - 9.3e-22 77.3 0.0 1.2e-21 76.9 0.0 1.1 1 0 0 1 1 1 1 MafB19-like deaminase Bd3614-deam PF14439.6 EGD94317.1 - 0.0094 16.0 0.2 0.027 14.5 0.2 1.8 1 1 0 1 1 1 1 Bd3614-like deaminase SNAD4 PF18750.1 EGD94317.1 - 0.01 16.0 0.0 0.017 15.3 0.0 1.3 1 0 0 1 1 1 0 Secreted Novel AID/APOBEC-like Deaminase 4 APOBEC3 PF18771.1 EGD94317.1 - 0.053 13.6 0.0 0.082 13.0 0.0 1.2 1 0 0 1 1 1 0 APOBEC3 XOO_2897-deam PF14440.6 EGD94317.1 - 0.081 13.0 0.0 0.13 12.4 0.0 1.3 1 0 0 1 1 1 0 Xanthomonas XOO_2897-like deaminase NADH-u_ox-rdase PF10785.9 EGD94318.1 - 5.4e-27 94.3 0.4 1.5e-26 92.9 0.2 1.7 2 0 0 2 2 2 1 NADH-ubiquinone oxidoreductase complex I, 21 kDa subunit NADH_u_ox_C PF12853.7 EGD94318.1 - 2e-26 91.8 0.1 2.9e-26 91.2 0.1 1.2 1 0 0 1 1 1 1 C-terminal of NADH-ubiquinone oxidoreductase 21 kDa subunit Swi3 PF07962.12 EGD94319.1 - 2.4e-31 107.5 0.1 5e-31 106.5 0.1 1.5 1 0 0 1 1 1 1 Replication Fork Protection Component Swi3 Peptidase_U32 PF01136.19 EGD94319.1 - 0.19 10.8 0.0 0.29 10.3 0.0 1.2 1 0 0 1 1 1 0 Peptidase family U32 RCC1 PF00415.18 EGD94320.1 - 2.6e-61 204.0 14.9 1.8e-10 41.3 0.3 7.6 7 1 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EGD94320.1 - 6.3e-42 140.6 35.9 5.6e-08 32.4 1.0 6.4 6 0 0 6 6 6 6 Regulator of chromosome condensation (RCC1) repeat RibD_C PF01872.17 EGD94321.1 - 7.3e-29 101.0 0.0 1.4e-28 100.1 0.0 1.5 1 0 0 1 1 1 1 RibD C-terminal domain Nic96 PF04097.14 EGD94322.1 - 6.3e-221 735.1 0.0 7.9e-221 734.8 0.0 1.0 1 0 0 1 1 1 1 Nup93/Nic96 Nucleoporin_FG PF13634.6 EGD94322.1 - 0.95 10.4 28.1 0.12 13.2 17.6 2.6 2 0 0 2 2 2 0 Nucleoporin FG repeat region COX16 PF14138.6 EGD94323.1 - 7.3e-32 109.7 0.2 9.4e-32 109.4 0.2 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein COX16 Y_phosphatase PF00102.27 EGD94324.1 - 2.8e-65 220.2 0.0 4.4e-65 219.5 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Rhodanese PF00581.20 EGD94324.1 - 4.4e-10 40.0 0.0 1.5e-09 38.3 0.0 1.9 2 0 0 2 2 2 1 Rhodanese-like domain DSPc PF00782.20 EGD94324.1 - 0.086 12.7 2.3 0.19 11.5 2.3 1.5 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain F-box PF00646.33 EGD94325.1 - 0.0016 18.3 2.2 0.0033 17.3 2.2 1.6 1 0 0 1 1 1 1 F-box domain F-box-like_2 PF13013.6 EGD94325.1 - 0.002 18.0 0.3 0.0065 16.4 0.2 1.9 2 0 0 2 2 2 1 F-box-like domain F-box-like PF12937.7 EGD94325.1 - 2.9 7.9 6.1 0.88 9.5 2.5 2.0 2 0 0 2 2 2 0 F-box-like PPP4R2 PF09184.11 EGD94325.1 - 3.7 7.1 8.2 6.4 6.3 8.2 1.3 1 0 0 1 1 1 0 PPP4R2 RNA_pol_3_Rpc31 PF11705.8 EGD94325.1 - 4.2 7.6 14.1 7 6.8 14.1 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 FGGY_C PF02782.16 EGD94327.1 - 1.6e-50 171.6 0.2 2.5e-50 171.0 0.2 1.4 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.21 EGD94327.1 - 9.2e-23 81.1 0.0 1e-21 77.7 0.0 2.2 1 1 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain BcrAD_BadFG PF01869.20 EGD94327.1 - 0.066 12.7 0.1 0.17 11.3 0.0 1.7 2 0 0 2 2 2 0 BadF/BadG/BcrA/BcrD ATPase family F-box-like PF12937.7 EGD94328.1 - 0.0089 15.9 0.1 0.031 14.2 0.1 2.0 1 0 0 1 1 1 1 F-box-like AAA PF00004.29 EGD94330.1 - 1.7e-43 148.2 0.0 2.8e-43 147.5 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EGD94330.1 - 4.4e-14 52.0 0.0 1e-13 50.8 0.0 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_2 PF07724.14 EGD94330.1 - 9.2e-08 32.4 0.0 1.9e-07 31.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 EGD94330.1 - 1.6e-07 31.4 0.0 3.9e-07 30.2 0.0 1.7 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EGD94330.1 - 2e-06 28.3 0.0 0.00012 22.6 0.0 2.8 2 1 0 3 3 3 1 AAA ATPase domain AAA_22 PF13401.6 EGD94330.1 - 2.8e-05 24.4 0.2 0.0064 16.8 0.2 2.4 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.12 EGD94330.1 - 6e-05 22.9 0.0 0.00012 21.9 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 EGD94330.1 - 0.00099 19.7 0.0 0.02 15.4 0.0 2.5 2 0 0 2 2 2 1 AAA domain TIP49 PF06068.13 EGD94330.1 - 0.001 18.4 0.0 0.0021 17.3 0.0 1.5 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_33 PF13671.6 EGD94330.1 - 0.0016 18.6 0.0 0.0031 17.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 EGD94330.1 - 0.0029 17.4 0.0 0.0054 16.5 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_3 PF07726.11 EGD94330.1 - 0.0036 17.2 0.0 0.01 15.7 0.0 1.8 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.21 EGD94330.1 - 0.0081 15.6 0.0 0.018 14.4 0.0 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI ATPase PF06745.13 EGD94330.1 - 0.0091 15.4 0.0 0.02 14.2 0.0 1.5 1 0 0 1 1 1 1 KaiC TsaE PF02367.17 EGD94330.1 - 0.011 15.8 0.0 0.021 14.8 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_28 PF13521.6 EGD94330.1 - 0.012 15.9 0.0 0.021 15.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain DUF815 PF05673.13 EGD94330.1 - 0.022 13.9 0.0 0.04 13.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Sigma54_activat PF00158.26 EGD94330.1 - 0.023 14.4 0.0 0.1 12.3 0.0 2.0 3 0 0 3 3 2 0 Sigma-54 interaction domain AAA_7 PF12775.7 EGD94330.1 - 0.025 14.1 0.0 0.047 13.2 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region HR1 PF02185.16 EGD94330.1 - 0.037 14.1 0.7 0.095 12.8 0.7 1.7 1 0 0 1 1 1 0 Hr1 repeat RNA_helicase PF00910.22 EGD94330.1 - 0.037 14.4 0.0 0.067 13.6 0.0 1.4 1 0 0 1 1 1 0 RNA helicase PhoH PF02562.16 EGD94330.1 - 0.037 13.5 0.0 0.14 11.6 0.0 1.9 2 0 0 2 2 2 0 PhoH-like protein AAA_14 PF13173.6 EGD94330.1 - 0.038 14.0 0.0 0.064 13.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 EGD94330.1 - 0.04 13.6 0.0 0.1 12.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 EGD94330.1 - 0.064 12.8 0.0 0.17 11.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain Parvo_NS1 PF01057.17 EGD94330.1 - 0.065 12.3 0.0 0.11 11.6 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 Zeta_toxin PF06414.12 EGD94330.1 - 0.12 11.7 0.0 0.2 10.9 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin Prot_ATP_ID_OB PF16450.5 EGD94330.1 - 0.12 12.3 1.2 0.44 10.5 1.2 2.0 1 1 0 1 1 1 0 Proteasomal ATPase OB C-terminal domain Na_Ca_ex PF01699.24 EGD94331.1 - 2.3e-21 76.4 37.2 1.7e-15 57.3 13.4 3.5 5 1 0 5 5 5 2 Sodium/calcium exchanger protein YccF PF03733.13 EGD94331.1 - 6.7e-15 55.5 10.9 6.7e-15 55.5 10.9 4.4 5 0 0 5 5 5 1 Inner membrane component domain Peptidase_S10 PF00450.22 EGD94332.1 - 5.7e-88 296.1 0.6 8.3e-88 295.6 0.6 1.2 1 0 0 1 1 1 1 Serine carboxypeptidase Choline_transpo PF04515.12 EGD94333.1 - 1.9e-81 273.8 22.9 1.9e-81 273.8 22.9 2.1 2 0 0 2 2 2 1 Plasma-membrane choline transporter tRNA-synt_1g PF09334.11 EGD94334.1 - 4.4e-141 470.1 0.0 5.9e-141 469.7 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 EGD94334.1 - 0.00038 18.9 0.6 0.0043 15.4 0.0 2.5 2 1 0 2 2 2 1 tRNA synthetases class I (I, L, M and V) HNH_2 PF13391.6 EGD94336.1 - 3.5e-19 68.7 0.0 8.9e-19 67.4 0.0 1.7 2 0 0 2 2 2 1 HNH endonuclease Alk_phosphatase PF00245.20 EGD94336.1 - 0.19 10.6 0.0 0.28 10.1 0.0 1.2 1 0 0 1 1 1 0 Alkaline phosphatase Glyoxalase PF00903.25 EGD94337.1 - 0.056 13.6 0.0 0.42 10.8 0.0 2.0 1 1 0 1 1 1 0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily EMG1 PF03587.14 EGD94338.1 - 5.1e-79 264.4 0.0 6e-79 264.2 0.0 1.0 1 0 0 1 1 1 1 EMG1/NEP1 methyltransferase UPF0506 PF11703.8 EGD94339.1 - 0.0066 16.8 4.8 0.0097 16.3 4.8 1.2 1 0 0 1 1 1 1 UPF0506 Colipase-like PF15083.6 EGD94339.1 - 0.031 14.4 2.0 0.041 14.0 2.0 1.1 1 0 0 1 1 1 0 Colipase-like Conotoxin_I2 PF17557.2 EGD94339.1 - 0.069 13.3 8.8 0.12 12.5 8.8 1.3 1 0 0 1 1 1 0 I2-superfamily conotoxins Toxin_18 PF08087.11 EGD94339.1 - 0.26 11.3 5.0 0.55 10.3 5.0 1.5 1 0 0 1 1 1 0 Conotoxin O-superfamily DEC-1_N PF04625.13 EGD94339.1 - 0.46 9.4 5.6 0.45 9.5 5.6 1.1 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region XPG_I PF00867.18 EGD94340.1 - 2.2e-29 101.6 0.0 2.2e-29 101.6 0.0 2.4 3 0 0 3 3 3 1 XPG I-region XPG_N PF00752.17 EGD94340.1 - 7.1e-20 71.4 1.4 6.4e-17 61.9 0.0 2.9 2 1 0 2 2 2 1 XPG N-terminal domain 5_3_exonuc PF01367.20 EGD94340.1 - 7.8e-05 23.2 0.6 0.00038 21.0 0.0 2.3 2 0 0 2 2 2 1 5'-3' exonuclease, C-terminal SAM fold HXXSHH PF07586.11 EGD94340.1 - 0.42 10.1 6.5 0.093 12.3 3.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1552) Linker_histone PF00538.19 EGD94341.1 - 2.6e-29 101.4 0.2 2.6e-29 101.4 0.2 2.4 3 1 1 4 4 4 1 linker histone H1 and H5 family SRP-alpha_N PF04086.13 EGD94341.1 - 0.049 13.5 31.5 0.067 13.1 31.5 1.2 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Toxin_trans PF07952.12 EGD94341.1 - 0.052 12.6 0.1 0.072 12.2 0.1 1.1 1 0 0 1 1 1 0 Clostridium neurotoxin, Translocation domain SAPS PF04499.15 EGD94341.1 - 0.75 8.5 8.0 1.1 8.0 8.0 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein MAM33 PF02330.16 EGD94341.1 - 6 6.7 8.7 0.54 10.2 0.2 2.2 1 1 0 2 2 2 0 Mitochondrial glycoprotein Pkinase PF00069.25 EGD94343.1 - 2.7e-11 43.3 0.0 3.8e-11 42.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD94343.1 - 0.00043 19.6 0.6 0.003 16.9 0.1 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase DUF2880 PF11082.8 EGD94343.1 - 0.14 12.5 0.0 0.38 11.1 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2880) Oxidored_q4 PF00507.19 EGD94344.1 - 5.1e-15 55.4 0.3 5.1e-15 55.4 0.3 1.4 1 1 0 1 1 1 1 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 DUF3169 PF11368.8 EGD94344.1 - 0.018 14.6 4.0 0.043 13.3 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3169) Pkinase PF00069.25 EGD94345.1 - 9.6e-21 74.3 0.0 4.5e-14 52.4 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EGD94345.1 - 2e-07 30.6 0.0 9.4e-07 28.4 0.0 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 EGD94345.1 - 2.4e-06 27.1 0.0 0.027 13.8 0.0 3.0 3 0 0 3 3 3 2 Kinase-like Pkinase_fungal PF17667.1 EGD94345.1 - 0.00048 19.0 0.4 0.00098 18.0 0.4 1.3 1 1 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EGD94345.1 - 0.0061 16.5 0.0 0.01 15.8 0.0 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 EGD94345.1 - 0.0082 15.5 0.0 0.014 14.8 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family PhnH PF05845.12 EGD94345.1 - 0.08 12.7 0.0 0.15 11.8 0.0 1.4 1 0 0 1 1 1 0 Bacterial phosphonate metabolism protein (PhnH) PIP5K PF01504.18 EGD94346.1 - 6.3e-101 337.2 0.1 6.3e-101 337.2 0.1 2.4 3 0 0 3 3 3 1 Phosphatidylinositol-4-phosphate 5-Kinase ANAPC1 PF12859.7 EGD94348.1 - 2.1e-32 112.4 1.3 2.1e-32 112.4 1.3 2.8 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 1 PC_rep PF01851.22 EGD94348.1 - 0.00036 20.8 9.3 0.011 16.1 0.1 4.7 5 0 0 5 5 5 2 Proteasome/cyclosome repeat Fungal_trans_2 PF11951.8 EGD94349.1 - 2.3e-60 204.5 0.2 4.2e-60 203.6 0.2 1.3 1 1 0 1 1 1 1 Fungal specific transcription factor domain MFS_1 PF07690.16 EGD94350.1 - 5e-26 91.5 26.7 5e-26 91.5 26.7 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily P5-ATPase PF12409.8 EGD94350.1 - 0.074 13.2 0.1 0.22 11.6 0.1 1.8 1 0 0 1 1 1 0 P5-type ATPase cation transporter Saf_2TM PF18303.1 EGD94350.1 - 5 6.7 5.4 1 8.9 0.0 2.6 3 1 1 4 4 4 0 SAVED-fused 2TM effector domain Herpes_ICP4_C PF03585.14 EGD94353.1 - 0.00017 20.5 0.1 0.00021 20.2 0.1 1.1 1 0 0 1 1 1 1 Herpesvirus ICP4-like protein C-terminal region RPAP1_C PF08620.10 EGD94354.1 - 8.9e-24 83.4 0.0 1.6e-23 82.6 0.0 1.4 1 0 0 1 1 1 1 RPAP1-like, C-terminal RPAP1_N PF08621.10 EGD94354.1 - 4.3e-15 55.2 7.9 4.3e-15 55.2 7.9 2.1 2 0 0 2 2 2 1 RPAP1-like, N-terminal ABC2_membrane PF01061.24 EGD94355.1 - 2.8e-74 249.1 61.0 2.4e-39 134.9 22.5 3.3 4 1 0 4 4 4 2 ABC-2 type transporter ABC_tran PF00005.27 EGD94355.1 - 9.8e-40 136.2 0.0 1.8e-18 67.4 0.0 3.2 4 0 0 4 4 3 2 ABC transporter PDR_CDR PF06422.12 EGD94355.1 - 3.5e-31 106.9 11.0 5.3e-26 90.3 0.0 3.7 4 0 0 4 4 3 2 CDR ABC transporter ABC_trans_N PF14510.6 EGD94355.1 - 2.5e-15 56.8 0.0 6.1e-15 55.6 0.0 1.7 1 0 0 1 1 1 1 ABC-transporter N-terminal AAA_33 PF13671.6 EGD94355.1 - 1.6e-07 31.5 0.2 0.0028 17.8 0.1 2.4 2 0 0 2 2 2 2 AAA domain ABC2_membrane_3 PF12698.7 EGD94355.1 - 3.5e-07 29.7 9.9 3.5e-07 29.7 9.9 3.6 2 2 1 3 3 3 1 ABC-2 family transporter protein AAA_25 PF13481.6 EGD94355.1 - 2.4e-06 27.3 0.0 5e-05 23.0 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 EGD94355.1 - 3.5e-06 26.7 0.5 0.0031 17.2 0.1 3.0 3 0 0 3 3 3 1 P-loop containing region of AAA domain AAA_21 PF13304.6 EGD94355.1 - 1.6e-05 24.9 0.1 0.22 11.3 0.1 3.1 2 1 1 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EGD94355.1 - 2.1e-05 24.1 0.0 0.095 12.1 0.0 3.3 2 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 EGD94355.1 - 4.4e-05 23.4 0.1 0.0015 18.4 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase AAA_16 PF13191.6 EGD94355.1 - 5.1e-05 23.7 0.2 0.002 18.5 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain AAA_18 PF13238.6 EGD94355.1 - 5.3e-05 23.8 0.0 0.00082 19.9 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_23 PF13476.6 EGD94355.1 - 0.0015 19.1 0.0 0.073 13.6 0.0 2.3 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 EGD94355.1 - 0.0019 18.3 0.1 2.8 8.1 0.0 2.5 2 0 0 2 2 2 2 50S ribosome-binding GTPase cobW PF02492.19 EGD94355.1 - 0.0044 16.6 0.6 0.036 13.7 0.1 2.2 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_22 PF13401.6 EGD94355.1 - 0.0068 16.7 0.8 0.43 10.8 0.2 3.3 3 1 0 3 3 3 1 AAA domain NACHT PF05729.12 EGD94355.1 - 0.0088 16.0 1.4 1.3 9.0 0.3 2.6 2 0 0 2 2 2 1 NACHT domain AAA PF00004.29 EGD94355.1 - 0.026 14.9 0.1 4.5 7.7 0.0 2.6 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 EGD94355.1 - 0.045 13.5 0.1 1.1 8.9 0.0 2.3 2 0 0 2 2 2 0 AAA domain ABC2_membrane_2 PF12679.7 EGD94355.1 - 0.048 12.9 20.8 0.022 14.1 10.6 2.4 2 0 0 2 2 2 0 ABC-2 family transporter protein AAA_17 PF13207.6 EGD94355.1 - 0.053 14.0 0.3 0.54 10.7 0.0 2.4 3 0 0 3 3 2 0 AAA domain RNA_helicase PF00910.22 EGD94355.1 - 0.059 13.8 0.0 26 5.3 0.0 2.9 2 0 0 2 2 2 0 RNA helicase Pax2_C PF12403.8 EGD94355.1 - 0.11 12.5 0.6 0.48 10.5 0.5 2.1 1 1 1 2 2 2 0 Paired-box protein 2 C terminal AAA_28 PF13521.6 EGD94355.1 - 0.14 12.4 0.2 0.39 10.9 0.2 1.8 1 0 0 1 1 1 0 AAA domain IDO PF01231.18 EGD94357.1 - 0.00011 21.1 2.9 0.00099 18.0 2.9 2.3 1 1 0 1 1 1 1 Indoleamine 2,3-dioxygenase FAD_binding_3 PF01494.19 EGD94358.1 - 2.5e-12 46.7 0.2 1.2e-08 34.6 0.1 2.8 2 1 0 2 2 2 2 FAD binding domain DAO PF01266.24 EGD94358.1 - 2.1e-05 24.3 0.3 0.00014 21.6 0.0 2.2 3 0 0 3 3 3 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EGD94358.1 - 6.8e-05 23.0 0.0 0.00016 21.8 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EGD94358.1 - 9.8e-05 21.7 0.2 0.14 11.3 0.0 2.4 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 EGD94358.1 - 0.00031 19.7 0.0 0.038 12.8 0.0 2.2 2 0 0 2 2 2 2 Tryptophan halogenase SE PF08491.10 EGD94358.1 - 0.0013 17.9 0.0 0.0023 17.0 0.0 1.4 1 1 0 1 1 1 1 Squalene epoxidase NAD_binding_9 PF13454.6 EGD94358.1 - 0.0078 16.2 0.0 0.047 13.7 0.0 2.0 2 0 0 2 2 2 1 FAD-NAD(P)-binding TetR_C_12 PF16914.5 EGD94358.1 - 0.15 12.2 0.1 0.31 11.2 0.1 1.4 1 0 0 1 1 1 0 Bacterial transcriptional repressor C-terminal GnRH PF00446.17 EGD94359.1 - 1.1 9.8 3.0 3 8.4 3.0 1.7 1 0 0 1 1 1 0 Gonadotropin-releasing hormone Methyltransf_23 PF13489.6 EGD94360.1 - 8.7e-17 61.5 0.0 1.7e-16 60.5 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EGD94360.1 - 1.8e-08 35.0 0.0 7.5e-08 33.0 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EGD94360.1 - 3.2e-07 30.3 0.0 0.02 14.7 0.0 2.3 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_12 PF08242.12 EGD94360.1 - 6.5e-07 30.0 0.0 1.6e-05 25.5 0.0 2.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EGD94360.1 - 3.8e-06 27.4 0.0 1.1e-05 26.0 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 EGD94360.1 - 0.063 12.7 0.0 1.7 8.1 0.0 2.2 2 0 0 2 2 2 0 Putative methyltransferase MTS PF05175.14 EGD94360.1 - 0.07 12.7 0.0 0.29 10.7 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase small domain FtsJ PF01728.19 EGD94360.1 - 0.091 12.9 0.0 0.21 11.7 0.0 1.6 1 0 0 1 1 1 0 FtsJ-like methyltransferase Methyltransf_16 PF10294.9 EGD94360.1 - 0.16 11.7 0.0 0.84 9.3 0.0 1.9 2 0 0 2 2 2 0 Lysine methyltransferase IFRD PF05004.13 EGD94362.1 - 1e-81 274.4 12.1 1.3e-81 274.1 12.1 1.1 1 0 0 1 1 1 1 Interferon-related developmental regulator (IFRD) RRN3 PF05327.11 EGD94362.1 - 0.44 9.0 14.4 0.52 8.8 4.2 2.1 2 0 0 2 2 2 0 RNA polymerase I specific transcription initiation factor RRN3 ORC6 PF05460.13 EGD94362.1 - 3 7.0 10.1 0.19 11.0 3.7 1.9 2 0 0 2 2 2 0 Origin recognition complex subunit 6 (ORC6) Pkinase PF00069.25 EGD94363.1 - 1.2e-63 214.9 0.0 1.5e-63 214.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD94363.1 - 6.6e-35 120.6 0.0 9.2e-35 120.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EGD94363.1 - 7.7e-05 21.6 0.0 0.00012 21.0 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 EGD94363.1 - 0.051 12.9 0.0 0.089 12.1 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Seadorna_VP7 PF07387.11 EGD94363.1 - 0.098 11.7 0.0 0.14 11.1 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 APH PF01636.23 EGD94363.1 - 0.11 12.4 0.0 0.23 11.4 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EGD94363.1 - 0.12 11.3 0.0 0.2 10.5 0.0 1.3 1 1 0 1 1 1 0 Haspin like kinase domain SH2_2 PF14633.6 EGD94364.1 - 1.1e-86 289.7 2.2 2.7e-86 288.5 0.0 2.4 2 0 0 2 2 2 1 SH2 domain HTH_44 PF14641.6 EGD94364.1 - 4.7e-37 126.9 0.5 1.3e-36 125.5 0.5 1.8 1 0 0 1 1 1 1 Helix-turn-helix DNA-binding domain of SPT6 HHH_7 PF14635.6 EGD94364.1 - 6.8e-31 106.7 0.0 1.5e-30 105.6 0.0 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix motif YqgF PF14639.6 EGD94364.1 - 1.6e-29 102.6 0.0 4.6e-29 101.1 0.0 1.9 1 0 0 1 1 1 1 Holliday-junction resolvase-like of SPT6 SPT6_acidic PF14632.6 EGD94364.1 - 5.1e-07 30.2 18.1 5.1e-07 30.2 18.1 4.9 5 1 1 6 6 6 1 Acidic N-terminal SPT6 HHH_3 PF12836.7 EGD94364.1 - 1.5e-05 25.1 0.0 4.6e-05 23.6 0.0 1.9 1 0 0 1 1 1 1 Helix-hairpin-helix motif HHH_9 PF17674.1 EGD94364.1 - 4.3e-05 24.3 10.1 0.00017 22.5 3.4 4.2 2 2 1 3 3 3 1 HHH domain SH2 PF00017.24 EGD94364.1 - 0.00032 20.7 0.0 0.00093 19.2 0.0 1.9 1 0 0 1 1 1 1 SH2 domain Tex_YqgF PF16921.5 EGD94364.1 - 0.13 12.7 0.0 0.57 10.6 0.0 2.1 2 0 0 2 2 2 0 Tex protein YqgF-like domain Acetyltransf_3 PF13302.7 EGD94365.1 - 5.4e-22 79.0 0.0 7.2e-22 78.5 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EGD94365.1 - 5.4e-06 26.6 0.0 6.6e-05 23.1 0.0 2.1 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.10 EGD94365.1 - 0.075 13.0 0.0 0.14 12.1 0.0 1.4 1 0 0 1 1 1 0 FR47-like protein TBPIP PF07106.13 EGD94367.1 - 5.8e-17 61.4 0.3 1.1e-16 60.5 0.3 1.5 1 0 0 1 1 1 1 TBPIP/Hop2 winged helix domain PspA_IM30 PF04012.12 EGD94367.1 - 0.0015 18.2 6.7 0.0015 18.2 6.7 1.9 1 1 1 2 2 2 1 PspA/IM30 family Penicillinase_R PF03965.16 EGD94367.1 - 0.004 17.5 2.8 0.0052 17.1 1.8 1.7 1 1 0 1 1 1 1 Penicillinase repressor DUF4140 PF13600.6 EGD94367.1 - 0.014 15.9 5.4 0.034 14.6 1.6 2.4 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) HutP PF09021.11 EGD94367.1 - 0.016 15.5 0.7 0.031 14.6 0.3 1.7 1 1 1 2 2 2 0 HutP ABC_tran_CTD PF16326.5 EGD94367.1 - 0.019 15.2 3.4 3.1 8.1 1.7 2.7 1 1 1 2 2 2 0 ABC transporter C-terminal domain Spc7 PF08317.11 EGD94367.1 - 0.052 12.4 8.2 0.069 12.0 8.2 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein TFIIE_beta PF02186.15 EGD94367.1 - 0.14 12.5 1.7 0.29 11.4 0.2 2.2 2 1 0 2 2 2 0 TFIIE beta subunit core domain DUF5320 PF17253.2 EGD94367.1 - 0.33 12.1 1.2 1.1 10.3 0.3 2.3 1 1 1 2 2 2 0 Family of unknown function (DUF5320) HalX PF08663.10 EGD94367.1 - 0.5 10.7 5.5 11 6.5 0.9 2.5 1 1 1 2 2 2 0 HalX domain YabA PF06156.13 EGD94367.1 - 0.77 10.4 4.1 4.3 8.0 4.1 2.2 1 1 0 1 1 1 0 Initiation control protein YabA Uso1_p115_C PF04871.13 EGD94367.1 - 1.1 9.6 10.0 2.3 8.6 10.0 1.6 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region FlxA PF14282.6 EGD94367.1 - 4 7.5 9.5 1.7 8.6 4.6 2.5 2 1 0 2 2 2 0 FlxA-like protein Sel1 PF08238.12 EGD94368.1 - 1.8e-10 41.1 5.7 1.8e-07 31.6 0.1 3.8 4 1 0 4 4 4 2 Sel1 repeat Helicase_C_2 PF13307.6 EGD94369.1 - 3.5e-53 180.3 0.0 9.2e-53 178.9 0.0 1.8 1 0 0 1 1 1 1 Helicase C-terminal domain DEAD_2 PF06733.15 EGD94369.1 - 1.2e-45 155.3 0.4 3.3e-45 153.9 0.4 1.7 1 1 0 1 1 1 1 DEAD_2 AAA_22 PF13401.6 EGD94369.1 - 0.011 16.0 0.3 0.21 11.9 0.3 2.7 2 1 0 2 2 2 0 AAA domain MAJIN PF15077.6 EGD94369.1 - 0.033 14.0 1.1 1.3 8.8 2.1 2.6 3 0 0 3 3 3 0 Membrane-anchored junction protein Ribosomal_L27A PF00828.19 EGD94370.1 - 2.4e-22 80.0 0.0 3.3e-22 79.5 0.0 1.2 1 0 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A Hydrolase_4 PF12146.8 EGD94371.1 - 0.011 15.0 0.0 0.75 9.0 0.0 2.1 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 EGD94371.1 - 0.097 12.1 0.0 5.8 6.3 0.0 2.2 1 1 0 2 2 2 0 Prolyl oligopeptidase family PLDc PF00614.22 EGD94372.1 - 2.2e-17 62.4 0.4 4.6e-08 32.9 0.2 2.7 2 0 0 2 2 2 2 Phospholipase D Active site motif PLDc_2 PF13091.6 EGD94372.1 - 4.6e-13 49.2 0.0 7.5e-07 29.1 0.0 2.9 3 0 0 3 3 3 2 PLD-like domain PX PF00787.24 EGD94372.1 - 9.4e-10 38.5 1.1 2.2e-09 37.3 0.2 2.1 2 0 0 2 2 2 1 PX domain AA_permease PF00324.21 EGD94373.1 - 3.1e-47 161.3 18.0 7.2e-33 113.9 8.8 2.7 2 1 0 2 2 2 2 Amino acid permease AA_permease_2 PF13520.6 EGD94373.1 - 9.5e-19 67.5 16.9 6.1e-16 58.3 3.9 2.3 2 1 0 2 2 2 2 Amino acid permease MtN3_slv PF03083.16 EGD94373.1 - 5.1 7.2 8.2 2 8.5 0.2 3.6 4 0 0 4 4 4 0 Sugar efflux transporter for intercellular exchange Herpes_BBRF1 PF04793.12 EGD94375.1 - 0.032 13.3 0.0 1.7 7.6 0.0 2.5 2 0 0 2 2 2 0 BRRF1-like protein Methyltransf_31 PF13847.6 EGD94376.1 - 2.9e-28 98.6 0.0 4.9e-28 97.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EGD94376.1 - 6.5e-19 68.4 0.4 1.5e-18 67.3 0.0 1.8 3 0 0 3 3 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EGD94376.1 - 1.4e-16 60.9 0.3 8.2e-16 58.4 0.0 2.2 3 0 0 3 3 2 1 Methyltransferase domain Ubie_methyltran PF01209.18 EGD94376.1 - 1.2e-15 57.5 0.2 2.6e-15 56.4 0.1 1.6 1 1 1 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.6 EGD94376.1 - 2.5e-09 37.2 0.0 5.1e-09 36.2 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 EGD94376.1 - 3e-09 37.0 0.0 6e-09 36.0 0.0 1.4 1 1 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_12 PF08242.12 EGD94376.1 - 1.6e-07 32.0 0.0 2.7e-07 31.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 EGD94376.1 - 5e-07 29.4 0.4 8.7e-07 28.6 0.4 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 EGD94376.1 - 2.5e-05 23.9 0.1 5e-05 22.9 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_32 PF13679.6 EGD94376.1 - 3.4e-05 23.9 0.0 5.6e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 EGD94376.1 - 0.00013 21.4 0.0 0.00017 21.0 0.0 1.3 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase DOT1 PF08123.13 EGD94376.1 - 0.002 17.7 1.4 0.0037 16.8 0.5 1.9 2 1 0 2 2 2 1 Histone methylation protein DOT1 UPF0020 PF01170.18 EGD94376.1 - 0.002 17.8 0.1 0.0036 17.0 0.1 1.3 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_3 PF01596.17 EGD94376.1 - 0.0069 15.6 0.1 0.016 14.4 0.1 1.6 1 1 0 1 1 1 1 O-methyltransferase Methyltransf_4 PF02390.17 EGD94376.1 - 0.0075 15.8 0.4 0.03 13.8 0.3 2.1 3 0 0 3 3 3 1 Putative methyltransferase Methyltransf_15 PF09445.10 EGD94376.1 - 0.017 14.7 0.0 0.024 14.2 0.0 1.3 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase Methyltransf_18 PF12847.7 EGD94376.1 - 0.026 14.4 0.1 0.049 13.6 0.1 1.4 1 0 0 1 1 1 0 Methyltransferase domain ADH_zinc_N PF00107.26 EGD94376.1 - 0.034 14.1 0.1 0.47 10.5 0.1 2.6 1 1 1 2 2 2 0 Zinc-binding dehydrogenase FtsJ PF01728.19 EGD94376.1 - 0.14 12.3 0.1 0.24 11.5 0.1 1.5 1 1 0 1 1 1 0 FtsJ-like methyltransferase bZIP_1 PF00170.21 EGD94377.1 - 0.047 13.8 5.7 0.077 13.1 5.5 1.4 1 1 0 1 1 1 0 bZIP transcription factor Peptidase_S41 PF03572.18 EGD94378.1 - 5.1e-08 32.7 0.0 1.1e-07 31.6 0.0 1.5 1 1 0 1 1 1 1 Peptidase family S41 Ras PF00071.22 EGD94379.1 - 2.5e-37 128.0 0.0 6.8e-24 84.3 0.0 2.1 2 0 0 2 2 2 2 Ras family Roc PF08477.13 EGD94379.1 - 1.5e-10 41.4 0.0 3.6e-10 40.1 0.0 1.7 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EGD94379.1 - 0.016 14.7 0.0 0.06 12.8 0.0 1.8 2 0 0 2 2 2 0 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EGD94379.1 - 0.017 15.2 0.0 0.034 14.2 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EGD94379.1 - 0.073 12.6 0.0 1.2 8.7 0.0 2.5 2 1 0 2 2 2 0 Elongation factor Tu GTP binding domain Zn_clus PF00172.18 EGD94380.1 - 7.3e-09 35.6 10.7 1.1e-08 35.1 10.7 1.2 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Aldose_epim PF01263.20 EGD94381.1 - 5.5e-58 196.6 0.0 6.5e-58 196.4 0.0 1.0 1 0 0 1 1 1 1 Aldose 1-epimerase Glyoxalase_6 PF18029.1 EGD94382.1 - 6.8e-06 26.8 0.0 8.9e-06 26.5 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase-like domain Glyoxalase PF00903.25 EGD94382.1 - 0.0075 16.5 0.0 0.015 15.5 0.0 1.5 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_2 PF12681.7 EGD94382.1 - 0.13 12.2 0.0 0.23 11.4 0.0 1.5 1 1 0 1 1 1 0 Glyoxalase-like domain SseB_C PF14581.6 EGD94382.1 - 0.16 12.1 0.0 0.2 11.8 0.0 1.1 1 0 0 1 1 1 0 SseB protein C-terminal domain QRPTase_C PF01729.19 EGD94383.1 - 3.6e-48 163.5 0.5 4.9e-25 88.2 0.1 2.1 1 1 1 2 2 2 2 Quinolinate phosphoribosyl transferase, C-terminal domain QRPTase_N PF02749.16 EGD94383.1 - 4.4e-23 81.2 0.0 1.3e-22 79.7 0.0 1.8 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, N-terminal domain DUF768 PF05589.11 EGD94383.1 - 4.7 7.3 5.3 14 5.8 0.6 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF768) Mto2_bdg PF12808.7 EGD94384.1 - 2.8e-30 104.3 32.0 1.7e-19 69.8 20.1 10.0 11 1 0 11 11 11 2 Micro-tubular organiser Mto1 C-term Mto2-binding region Cnn_1N PF07989.11 EGD94384.1 - 2.3e-22 78.9 9.5 2.3e-22 78.9 9.5 11.8 8 2 5 13 13 13 2 Centrosomin N-terminal motif 1 Fib_alpha PF08702.10 EGD94384.1 - 0.0015 18.8 7.1 0.0015 18.8 7.1 7.9 4 1 4 8 8 8 3 Fibrinogen alpha/beta chain family DUF1664 PF07889.12 EGD94384.1 - 0.29 11.2 0.0 0.29 11.2 0.0 8.2 4 1 4 8 8 8 0 Protein of unknown function (DUF1664) DUF2935 PF11155.8 EGD94384.1 - 1.9 8.9 10.5 7.3 7.0 0.3 5.7 3 1 2 5 5 5 0 Domain of unknown function (DUF2935) Sec7 PF01369.20 EGD94385.1 - 3.2e-28 98.6 0.0 6.2e-28 97.7 0.0 1.4 1 0 0 1 1 1 1 Sec7 domain PH_9 PF15410.6 EGD94385.1 - 1.1e-19 71.0 0.0 2.5e-19 69.8 0.0 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain COesterase PF00135.28 EGD94387.1 - 2e-31 109.5 0.0 8.7e-21 74.4 0.0 2.4 1 1 2 3 3 3 3 Carboxylesterase family UNC-50 PF05216.13 EGD94388.1 - 3.6e-72 242.5 7.4 4.4e-72 242.2 7.4 1.0 1 0 0 1 1 1 1 UNC-50 family FAD_binding_3 PF01494.19 EGD94390.1 - 4.5e-16 59.0 0.0 2.5e-09 36.9 0.1 3.0 2 1 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.6 EGD94390.1 - 3.5e-07 30.4 0.0 8.2e-07 29.2 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EGD94390.1 - 1.3e-06 27.8 0.0 0.0017 17.7 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EGD94390.1 - 3.2e-06 27.6 0.0 0.00065 20.2 0.0 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EGD94390.1 - 4.5e-05 23.2 0.0 6.2e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EGD94390.1 - 0.0046 16.1 0.0 0.007 15.5 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain PQQ PF01011.21 EGD94390.1 - 0.023 14.6 0.0 0.051 13.5 0.0 1.5 1 0 0 1 1 1 0 PQQ enzyme repeat HI0933_like PF03486.14 EGD94390.1 - 0.13 10.9 0.0 0.38 9.4 0.0 1.6 2 0 0 2 2 2 0 HI0933-like protein TrkA_N PF02254.18 EGD94390.1 - 0.13 12.5 0.0 0.22 11.8 0.0 1.3 1 0 0 1 1 1 0 TrkA-N domain Lycopene_cycl PF05834.12 EGD94390.1 - 0.17 10.9 0.1 0.35 9.9 0.0 1.5 2 0 0 2 2 2 0 Lycopene cyclase protein Pyr_redox_3 PF13738.6 EGD94390.1 - 0.24 10.6 0.0 1 8.5 0.0 1.8 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase MFS_1 PF07690.16 EGD94392.1 - 2.4e-34 118.8 28.6 3.9e-34 118.1 28.6 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_4 PF06779.14 EGD94392.1 - 0.0027 17.1 23.1 0.48 9.7 23.1 2.3 1 1 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB Holin_BhlA PF10960.8 EGD94392.1 - 0.14 12.2 0.1 0.46 10.5 0.0 1.9 2 0 0 2 2 2 0 BhlA holin family PP28 PF10252.9 EGD94393.1 - 9.4e-29 99.7 20.7 9.4e-29 99.7 20.7 3.9 2 2 1 3 3 3 1 Casein kinase substrate phosphoprotein PP28 MFS_1 PF07690.16 EGD94394.1 - 4.6e-18 65.3 49.6 1.1e-17 64.1 40.0 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Acetyltransf_1 PF00583.25 EGD94395.1 - 7e-13 48.8 0.0 1e-12 48.3 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EGD94395.1 - 4.2e-09 36.7 0.0 7.9e-09 35.8 0.0 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EGD94395.1 - 5.6e-08 32.8 0.0 9.9e-08 32.0 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EGD94395.1 - 4.5e-06 26.5 0.0 7.8e-06 25.8 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_CG PF14542.6 EGD94395.1 - 0.00063 19.8 0.0 0.0011 19.0 0.0 1.3 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase PanZ PF12568.8 EGD94395.1 - 0.036 13.8 0.0 0.06 13.1 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain, PanZ Acetyltransf_3 PF13302.7 EGD94395.1 - 0.048 14.3 0.0 0.06 14.0 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Glyco_transf_20 PF00982.21 EGD94396.1 - 1.2e-148 495.8 0.0 1.8e-148 495.2 0.0 1.3 1 1 0 1 1 1 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.16 EGD94396.1 - 3.1e-82 275.2 0.0 5.8e-82 274.3 0.0 1.5 1 0 0 1 1 1 1 Trehalose-phosphatase Glyco_hydro_44 PF12891.7 EGD94397.1 - 0.11 12.4 0.0 0.15 12.0 0.0 1.2 1 0 0 1 1 1 0 Glycoside hydrolase family 44 LETM1 PF07766.13 EGD94398.1 - 6.5e-10 38.8 0.2 1.6e-05 24.4 0.2 2.4 1 1 1 2 2 2 2 LETM1-like protein N_BRCA1_IG PF16158.5 EGD94399.1 - 1.9e-30 105.6 0.0 4.2e-30 104.5 0.0 1.6 1 0 0 1 1 1 1 Ig-like domain from next to BRCA1 gene ZZ PF00569.17 EGD94399.1 - 1e-16 60.4 36.3 9.9e-07 28.5 8.5 3.6 3 0 0 3 3 3 3 Zinc finger, ZZ type C1_2 PF03107.16 EGD94399.1 - 0.034 14.4 36.7 0.063 13.6 9.5 3.9 3 0 0 3 3 3 0 C1 domain Btz PF09405.10 EGD94401.1 - 2e-23 83.1 6.6 2e-23 83.1 6.6 2.6 2 1 0 2 2 2 1 CASC3/Barentsz eIF4AIII binding RRM_1 PF00076.22 EGD94402.1 - 1.1e-22 79.7 0.3 9e-15 54.3 0.0 3.4 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EGD94402.1 - 0.0029 17.7 0.1 0.066 13.3 0.0 2.8 2 1 0 2 2 2 1 RNA recognition motif Nup35_RRM_2 PF14605.6 EGD94402.1 - 0.12 12.4 0.0 0.35 10.9 0.0 1.8 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif DUF4604 PF15377.6 EGD94402.1 - 0.44 10.9 23.4 2.1 8.7 3.4 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4604) Spt5_N PF11942.8 EGD94402.1 - 1.9 9.5 9.2 0.44 11.5 4.5 2.3 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal Ino80_Iec3 PF14612.6 EGD94403.1 - 2.7e-73 247.6 8.4 4.1e-73 247.0 8.4 1.3 1 0 0 1 1 1 1 IEC3 subunit of the Ino80 complex, chromatin re-modelling ASFV_J13L PF05568.11 EGD94403.1 - 9.6 5.9 7.6 27 4.5 0.6 2.6 2 0 0 2 2 2 0 African swine fever virus J13L protein FAD_binding_4 PF01565.23 EGD94404.1 - 1e-18 67.4 0.5 1.8e-18 66.6 0.5 1.5 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EGD94404.1 - 1e-10 41.5 0.4 2.5e-10 40.3 0.1 1.9 2 0 0 2 2 2 1 Berberine and berberine like GFA PF04828.14 EGD94405.1 - 4.2e-20 71.9 0.8 5.7e-20 71.4 0.8 1.2 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme Dynamin_N PF00350.23 EGD94406.1 - 1.5e-34 119.5 0.1 3.6e-34 118.2 0.1 1.7 1 0 0 1 1 1 1 Dynamin family Dynamin_M PF01031.20 EGD94406.1 - 4.2e-20 72.1 1.4 2e-18 66.6 1.4 2.4 1 1 0 1 1 1 1 Dynamin central region MMR_HSR1 PF01926.23 EGD94406.1 - 5.7e-06 26.4 0.0 3e-05 24.1 0.0 2.2 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.6 EGD94406.1 - 0.0011 19.4 0.6 1.4 9.3 0.0 3.1 3 1 0 3 3 3 2 AAA ATPase domain GED PF02212.18 EGD94406.1 - 0.018 15.2 1.5 0.69 10.1 0.2 2.8 2 0 0 2 2 2 0 Dynamin GTPase effector domain Roc PF08477.13 EGD94406.1 - 0.02 15.1 0.4 0.78 10.0 0.0 3.2 4 0 0 4 4 4 0 Ras of Complex, Roc, domain of DAPkinase AAA_15 PF13175.6 EGD94406.1 - 0.075 12.7 5.8 0.14 11.9 0.6 3.1 2 1 0 2 2 2 0 AAA ATPase domain AAA_29 PF13555.6 EGD94406.1 - 0.12 12.1 0.0 0.27 11.0 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain FeoB_N PF02421.18 EGD94406.1 - 0.15 11.6 0.1 14 5.2 0.0 2.7 3 0 0 3 3 3 0 Ferrous iron transport protein B YABBY PF04690.13 EGD94406.1 - 0.2 12.2 0.8 0.38 11.3 0.0 1.8 2 0 0 2 2 2 0 YABBY protein AAA_23 PF13476.6 EGD94406.1 - 1.3 9.5 4.4 0.62 10.5 0.4 2.5 2 1 0 2 2 2 0 AAA domain ECR1_N PF14382.6 EGD94407.1 - 1.8e-14 53.3 0.6 4.2e-14 52.1 0.6 1.6 1 0 0 1 1 1 1 Exosome complex exonuclease RRP4 N-terminal region KH_6 PF15985.5 EGD94407.1 - 6.7e-06 26.4 0.2 1.2e-05 25.5 0.2 1.4 1 0 0 1 1 1 1 KH domain EXOSC1 PF10447.9 EGD94407.1 - 0.49 11.0 4.2 0.67 10.6 0.1 2.8 3 0 0 3 3 3 0 Exosome component EXOSC1/CSL4 Oxysterol_BP PF01237.18 EGD94408.1 - 5.3e-120 400.7 0.0 9.9e-120 399.8 0.0 1.5 1 0 0 1 1 1 1 Oxysterol-binding protein PH_8 PF15409.6 EGD94408.1 - 1.2e-39 134.4 0.9 4.7e-39 132.6 0.1 2.2 2 0 0 2 2 2 1 Pleckstrin homology domain PH PF00169.29 EGD94408.1 - 6.5e-06 26.6 0.9 2.7e-05 24.6 0.0 2.2 2 0 0 2 2 2 1 PH domain PH_11 PF15413.6 EGD94408.1 - 0.85 10.1 4.5 19 5.7 0.8 3.4 2 1 0 2 2 2 0 Pleckstrin homology domain Plus-3 PF03126.18 EGD94409.1 - 1.5e-29 102.7 0.0 1.1e-28 99.9 0.0 2.4 3 0 0 3 3 3 1 Plus-3 domain COQ7 PF03232.13 EGD94410.1 - 5.2e-68 228.2 0.4 6.4e-68 227.9 0.4 1.1 1 0 0 1 1 1 1 Ubiquinone biosynthesis protein COQ7 Rubrerythrin PF02915.17 EGD94410.1 - 0.006 17.0 0.0 0.015 15.7 0.0 1.6 2 0 0 2 2 2 1 Rubrerythrin Crr6 PF08847.11 EGD94410.1 - 0.026 14.2 0.1 1.4 8.6 0.0 2.3 1 1 1 2 2 2 0 Chlororespiratory reduction 6 DUF4455 PF14643.6 EGD94410.1 - 0.074 11.7 0.1 0.1 11.2 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4455) LMWPc PF01451.21 EGD94411.1 - 4.3e-37 127.6 0.0 5e-37 127.4 0.0 1.0 1 0 0 1 1 1 1 Low molecular weight phosphotyrosine protein phosphatase Chitin_synth_1 PF01644.17 EGD94412.1 - 3.5e-73 245.0 0.0 5.6e-73 244.3 0.0 1.3 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_1N PF08407.11 EGD94412.1 - 7.8e-30 102.7 0.0 1.6e-29 101.7 0.0 1.6 1 0 0 1 1 1 1 Chitin synthase N-terminal Chitin_synth_2 PF03142.15 EGD94412.1 - 2.8e-20 72.4 3.9 9.9e-17 60.7 0.0 2.2 2 0 0 2 2 2 2 Chitin synthase Glyco_trans_2_3 PF13632.6 EGD94412.1 - 0.0017 18.3 20.5 0.0018 18.2 14.5 3.2 2 1 0 2 2 2 1 Glycosyl transferase family group 2 Lipase_GDSL_2 PF13472.6 EGD94413.1 - 1.3e-10 42.0 0.1 4.2e-09 37.1 0.0 2.2 2 0 0 2 2 2 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 EGD94413.1 - 5.3e-05 23.3 0.0 0.0001 22.4 0.0 1.5 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase TMEM234 PF10639.9 EGD94414.1 - 2e-33 114.9 2.1 2.9e-32 111.1 2.1 2.0 1 1 0 1 1 1 1 Putative transmembrane family 234 EamA PF00892.20 EGD94414.1 - 0.0013 18.9 8.4 0.039 14.1 5.1 2.2 2 0 0 2 2 2 2 EamA-like transporter family MFS_MOT1 PF16983.5 EGD94415.1 - 3.1e-61 204.6 35.0 1e-32 112.8 9.8 3.2 3 0 0 3 3 3 2 Molybdate transporter of MFS superfamily PhyH PF05721.13 EGD94417.1 - 1.5e-42 146.2 0.0 1.9e-42 145.9 0.0 1.1 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) UTP15_C PF09384.10 EGD94418.1 - 1.1e-51 174.4 0.0 2e-51 173.6 0.0 1.4 1 0 0 1 1 1 1 UTP15 C terminal WD40 PF00400.32 EGD94418.1 - 2.2e-17 63.1 3.6 0.00042 21.1 0.1 4.6 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EGD94418.1 - 1.5e-07 31.6 0.1 0.11 12.8 0.0 4.3 4 1 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.6 EGD94418.1 - 0.00077 19.1 0.7 0.012 15.2 0.1 2.4 1 1 1 2 2 2 1 PQQ-like domain RAB3GAP2_N PF14655.6 EGD94418.1 - 0.02 14.2 0.1 4.7 6.4 0.1 2.3 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Nup160 PF11715.8 EGD94418.1 - 0.041 12.5 0.3 1.6 7.3 0.1 2.6 2 1 1 3 3 3 0 Nucleoporin Nup120/160 LRS4 PF10422.9 EGD94418.1 - 0.48 10.0 2.2 0.36 10.4 0.3 1.7 2 0 0 2 2 2 0 Monopolin complex subunit LRS4 C2 PF00168.30 EGD94419.1 - 3.7e-15 56.1 0.0 6.2e-15 55.4 0.0 1.4 1 0 0 1 1 1 1 C2 domain AAA_12 PF13087.6 EGD94420.1 - 6.4e-25 87.9 0.0 1.9e-19 70.1 0.0 2.5 1 1 1 2 2 2 2 AAA domain AAA_11 PF13086.6 EGD94420.1 - 4.4e-09 36.5 2.4 0.00079 19.3 0.0 2.6 3 0 0 3 3 3 2 AAA domain Viral_helicase1 PF01443.18 EGD94420.1 - 0.005 16.6 0.0 0.38 10.5 0.0 2.4 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase AAA_19 PF13245.6 EGD94420.1 - 0.0071 16.7 0.0 0.015 15.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain UvrD-helicase PF00580.21 EGD94420.1 - 0.0087 15.6 0.0 0.059 12.9 0.0 2.0 2 0 0 2 2 2 1 UvrD/REP helicase N-terminal domain AAA_30 PF13604.6 EGD94420.1 - 0.22 11.2 0.2 1.1 8.9 0.0 2.2 3 0 0 3 3 3 0 AAA domain Fungal_trans PF04082.18 EGD94421.1 - 1.3e-12 47.4 0.3 1.7e-12 46.9 0.3 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EGD94421.1 - 2.2e-10 40.5 10.5 4.4e-10 39.5 10.5 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain IBR PF01485.21 EGD94422.1 - 0.00043 20.4 6.8 0.00043 20.4 6.8 5.9 4 1 0 4 4 4 1 IBR domain, a half RING-finger domain IL4 PF00727.18 EGD94422.1 - 0.0045 17.2 0.0 3.3 8.0 0.1 2.8 2 0 0 2 2 2 2 Interleukin 4 OTU PF02338.19 EGD94423.1 - 2.5e-07 31.2 0.0 4.4e-07 30.4 0.0 1.4 1 0 0 1 1 1 1 OTU-like cysteine protease UN_NPL4 PF11543.8 EGD94423.1 - 0.012 16.1 0.0 0.032 14.7 0.0 1.7 1 0 0 1 1 1 0 Nuclear pore localisation protein NPL4 Cyclophil_like2 PF18050.1 EGD94423.1 - 0.035 14.1 0.0 0.075 13.0 0.0 1.5 1 0 0 1 1 1 0 Cyclophilin-like family UBX PF00789.20 EGD94423.1 - 0.036 14.3 0.2 0.28 11.4 0.0 2.3 1 1 1 2 2 2 0 UBX domain APC_r PF05923.12 EGD94423.1 - 0.23 11.2 1.0 0.47 10.2 1.0 1.5 1 0 0 1 1 1 0 APC repeat Bromodomain PF00439.25 EGD94424.1 - 5.7e-38 128.9 3.4 3.9e-20 71.7 0.2 2.5 2 0 0 2 2 2 2 Bromodomain BAH PF01426.18 EGD94424.1 - 3.5e-17 62.4 0.8 8e-17 61.2 0.8 1.7 1 0 0 1 1 1 1 BAH domain BLOC1S3 PF15753.5 EGD94424.1 - 0.74 9.9 9.2 2 8.5 1.1 2.4 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex 1 subunit 3 Nucleo_P87 PF07267.11 EGD94424.1 - 0.81 8.5 16.2 0.026 13.4 2.6 2.3 2 0 0 2 2 2 0 Nucleopolyhedrovirus capsid protein P87 CDC45 PF02724.14 EGD94424.1 - 2.5 6.3 14.4 0.01 14.2 4.4 1.8 2 0 0 2 2 2 0 CDC45-like protein Astro_capsid_p PF12226.8 EGD94424.1 - 3 6.9 7.3 6 5.9 7.3 1.4 1 0 0 1 1 1 0 Turkey astrovirus capsid protein MRC1 PF09444.10 EGD94425.1 - 1e-41 142.8 21.3 1e-41 142.8 21.3 5.5 4 1 1 5 5 5 2 MRC1-like domain Hydrolase_like PF13242.6 EGD94427.1 - 0.00049 20.1 0.0 0.0011 19.0 0.0 1.6 1 0 0 1 1 1 1 HAD-hyrolase-like Plus-3 PF03126.18 EGD94427.1 - 0.085 13.4 0.0 0.44 11.1 0.0 2.1 2 0 0 2 2 2 0 Plus-3 domain MIF4G PF02854.19 EGD94428.1 - 4.4e-23 82.0 4.4 9.9e-22 77.6 3.4 2.3 2 0 0 2 2 2 1 MIF4G domain MA3 PF02847.17 EGD94428.1 - 1.1e-17 64.0 0.5 3e-17 62.6 0.1 2.0 2 0 0 2 2 2 1 MA3 domain EST1_DNA_bind PF10373.9 EGD94428.1 - 0.00036 20.1 1.7 0.00077 19.0 1.7 1.5 1 0 0 1 1 1 1 Est1 DNA/RNA binding domain SRP14 PF02290.15 EGD94429.1 - 8.5e-29 99.8 0.0 1.1e-28 99.4 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle 14kD protein Inp1 PF12634.7 EGD94430.1 - 2.1e-37 128.2 0.1 4.8e-37 127.0 0.0 1.7 2 0 0 2 2 2 1 Inheritance of peroxisomes protein 1 EI24 PF07264.11 EGD94431.1 - 5e-12 46.4 5.0 1.1e-09 38.8 5.0 2.2 1 1 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) DUF3742 PF12553.8 EGD94431.1 - 0.5 10.5 0.1 0.5 10.5 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3742) Sugar_tr PF00083.24 EGD94433.1 - 1.1e-42 146.5 23.6 2.1e-27 96.1 6.9 3.1 3 0 0 3 3 3 2 Sugar (and other) transporter MFS_1 PF07690.16 EGD94433.1 - 9.1e-22 77.4 26.1 5.4e-21 74.9 20.9 2.9 1 1 0 2 2 2 1 Major Facilitator Superfamily NADH-u_ox-rdase PF10785.9 EGD94433.1 - 5.9 7.6 5.6 5.2 7.8 0.3 3.1 3 0 0 3 3 3 0 NADH-ubiquinone oxidoreductase complex I, 21 kDa subunit Pol_alpha_B_N PF08418.10 EGD94434.1 - 0.006 16.6 2.8 0.012 15.6 2.8 1.4 1 0 0 1 1 1 1 DNA polymerase alpha subunit B N-terminal Helo_like_N PF17111.5 EGD94434.1 - 0.087 12.2 0.3 0.46 9.8 0.1 2.0 2 0 0 2 2 2 0 Fungal N-terminal domain of STAND proteins MRNIP PF15749.5 EGD94434.1 - 0.77 10.5 2.1 1.5 9.6 0.1 2.2 2 0 0 2 2 2 0 MRN-interacting protein NADHdeh_related PF10125.9 EGD94435.1 - 0.044 13.2 0.0 0.057 12.8 0.0 1.1 1 0 0 1 1 1 0 NADH dehydrogenase I, subunit N related protein FixQ PF05545.11 EGD94436.1 - 0.092 12.7 0.1 0.3 11.1 0.1 1.9 1 0 0 1 1 1 0 Cbb3-type cytochrome oxidase component FixQ DUF3397 PF11877.8 EGD94436.1 - 1.9 8.7 17.0 0.28 11.4 0.6 3.4 2 2 1 3 3 3 0 Protein of unknown function (DUF3397) CPP1-like PF11833.8 EGD94436.1 - 6 6.5 6.5 0.73 9.5 1.7 1.9 2 0 0 2 2 2 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like DUF2841 PF11001.8 EGD94437.1 - 5.4e-35 120.1 0.0 7.8e-35 119.6 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2841) TNT PF14021.6 EGD94438.1 - 5.2e-30 103.8 0.0 7.7e-30 103.3 0.0 1.3 1 0 0 1 1 1 1 Tuberculosis necrotizing toxin FmdA_AmdA PF03069.15 EGD94439.1 - 1.1e-156 521.4 0.0 1.2e-155 518.0 0.0 1.9 1 1 0 1 1 1 1 Acetamidase/Formamidase family Pro_isomerase PF00160.21 EGD94440.1 - 3.7e-42 144.3 0.9 5.2e-42 143.8 0.1 1.6 2 0 0 2 2 2 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TPR_2 PF07719.17 EGD94440.1 - 1e-05 25.3 6.0 8.2e-05 22.4 1.1 3.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 EGD94440.1 - 5.6e-05 22.8 0.5 5.6e-05 22.8 0.5 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 EGD94440.1 - 0.0065 17.1 7.8 0.067 13.9 5.4 2.7 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_9 PF13371.6 EGD94440.1 - 0.0077 16.4 2.3 0.46 10.7 1.1 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 EGD94440.1 - 0.059 13.6 0.3 0.059 13.6 0.3 3.2 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_14 PF13428.6 EGD94440.1 - 0.71 10.8 4.3 0.69 10.9 1.2 2.6 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.6 EGD94440.1 - 0.71 10.2 7.6 1.8 8.9 5.3 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_11 PF13414.6 EGD94440.1 - 2.3 8.0 6.3 16 5.3 0.2 3.3 3 0 0 3 3 3 0 TPR repeat Tyr_Deacylase PF02580.16 EGD94441.1 - 1.5e-51 174.7 0.1 1.7e-51 174.5 0.1 1.0 1 0 0 1 1 1 1 D-Tyr-tRNA(Tyr) deacylase Not3 PF04065.15 EGD94442.1 - 4.9e-87 291.2 15.3 7.2e-87 290.6 15.3 1.2 1 0 0 1 1 1 1 Not1 N-terminal domain, CCR4-Not complex component NOT2_3_5 PF04153.18 EGD94442.1 - 4.1e-38 130.4 7.4 1e-37 129.2 7.4 1.7 1 0 0 1 1 1 1 NOT2 / NOT3 / NOT5 family CLZ PF16526.5 EGD94442.1 - 0.019 15.3 2.1 0.045 14.1 0.5 2.4 2 0 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels DUF2373 PF10180.9 EGD94442.1 - 0.082 12.8 4.8 0.19 11.6 4.8 1.5 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2373) Syntaxin_2 PF14523.6 EGD94442.1 - 0.47 10.9 7.7 0.071 13.5 2.1 2.5 2 0 0 2 2 2 0 Syntaxin-like protein zf-C2H2_aberr PF17017.5 EGD94444.1 - 0.00037 20.7 0.3 0.00065 19.9 0.3 1.4 1 0 0 1 1 1 1 Aberrant zinc-finger zf-C2H2 PF00096.26 EGD94444.1 - 0.0033 17.8 8.2 0.32 11.5 0.2 3.0 2 1 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EGD94444.1 - 0.04 14.8 5.4 0.07 14.0 0.2 2.9 2 1 0 2 2 2 0 C2H2-type zinc finger APH PF01636.23 EGD94445.1 - 2.3e-14 53.9 0.0 6.7e-14 52.4 0.0 1.7 2 1 0 2 2 2 1 Phosphotransferase enzyme family DNA_binding_1 PF01035.20 EGD94447.1 - 2.5e-24 85.2 0.0 3.7e-24 84.6 0.0 1.3 1 0 0 1 1 1 1 6-O-methylguanine DNA methyltransferase, DNA binding domain Rubella_Capsid PF05750.11 EGD94447.1 - 0.0037 16.9 0.2 0.0066 16.1 0.0 1.5 2 0 0 2 2 2 1 Rubella capsid protein Sugar_tr PF00083.24 EGD94448.1 - 8.3e-89 298.5 19.6 9.6e-89 298.3 19.6 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EGD94448.1 - 8.7e-19 67.6 49.2 1.5e-14 53.7 20.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 EGD94448.1 - 2.2 6.4 11.0 0.46 8.7 2.7 2.9 1 1 2 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family Pyr_redox_2 PF07992.14 EGD94449.1 - 5.4e-48 163.7 5.1 5.4e-48 163.7 5.1 1.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 EGD94449.1 - 2.1e-39 134.2 0.1 5.4e-39 132.8 0.1 1.8 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 EGD94449.1 - 3.5e-21 75.5 12.1 1.3e-20 73.7 1.1 3.1 3 1 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EGD94449.1 - 3.3e-11 43.2 8.3 1e-10 41.6 0.3 2.6 2 1 1 3 3 3 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EGD94449.1 - 1.1e-09 38.4 4.2 2.5e-05 24.4 0.4 2.5 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain GIDA PF01134.22 EGD94449.1 - 1.7e-08 34.0 13.1 3.1e-07 29.8 5.0 3.0 2 2 1 3 3 3 2 Glucose inhibited division protein A AlaDh_PNT_C PF01262.21 EGD94449.1 - 5.7e-07 29.1 4.0 0.003 16.9 0.3 3.2 3 1 1 4 4 4 2 Alanine dehydrogenase/PNT, C-terminal domain FAD_binding_2 PF00890.24 EGD94449.1 - 7.7e-07 28.5 2.5 7.7e-07 28.5 2.5 2.8 2 1 1 3 3 3 1 FAD binding domain HI0933_like PF03486.14 EGD94449.1 - 4.6e-06 25.6 10.4 0.00053 18.8 1.4 3.2 3 0 0 3 3 3 3 HI0933-like protein Thi4 PF01946.17 EGD94449.1 - 1.9e-05 24.0 2.8 0.00038 19.8 0.1 2.3 2 0 0 2 2 2 1 Thi4 family Pyr_redox_3 PF13738.6 EGD94449.1 - 2.8e-05 23.5 6.8 0.0057 16.0 0.1 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EGD94449.1 - 0.00025 20.8 12.6 0.04 13.5 0.9 3.8 4 0 0 4 4 4 2 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 EGD94449.1 - 0.00026 20.1 2.5 0.013 14.5 0.1 2.4 2 1 0 2 2 2 1 Lycopene cyclase protein K_oxygenase PF13434.6 EGD94449.1 - 0.013 14.7 0.3 0.086 12.0 0.0 2.1 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) FAD_binding_3 PF01494.19 EGD94449.1 - 0.022 14.0 7.4 0.18 11.0 1.3 2.4 2 0 0 2 2 2 0 FAD binding domain FMO-like PF00743.19 EGD94449.1 - 0.15 10.4 0.9 0.35 9.2 0.1 1.8 2 0 0 2 2 2 0 Flavin-binding monooxygenase-like NAD_binding_7 PF13241.6 EGD94449.1 - 0.19 12.2 2.4 2 8.9 0.1 3.0 3 0 0 3 3 3 0 Putative NAD(P)-binding Trp_halogenase PF04820.14 EGD94449.1 - 1.6 7.5 7.3 1 8.1 0.9 2.2 2 0 0 2 2 2 0 Tryptophan halogenase 3HCDH_N PF02737.18 EGD94449.1 - 4 7.3 7.3 0.39 10.6 0.7 2.5 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain PGM_PMM_I PF02878.16 EGD94451.1 - 1.9e-32 111.9 0.0 3.9e-32 110.9 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_II PF02879.16 EGD94451.1 - 4.6e-25 88.2 0.0 1e-24 87.1 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_III PF02880.16 EGD94451.1 - 3.8e-15 56.1 0.0 6.8e-15 55.3 0.0 1.4 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_IV PF00408.20 EGD94451.1 - 2.9e-07 30.5 0.0 9.2e-07 29.0 0.0 1.8 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain AdoMet_MTase PF07757.13 EGD94451.1 - 0.054 13.8 0.0 20 5.5 0.0 2.7 2 0 0 2 2 2 0 Predicted AdoMet-dependent methyltransferase FA_desaturase PF00487.24 EGD94452.1 - 2.4e-24 86.6 30.9 3.5e-24 86.0 30.9 1.3 1 0 0 1 1 1 1 Fatty acid desaturase Cyt-b5 PF00173.28 EGD94452.1 - 4.8e-11 42.6 0.0 1.2e-10 41.4 0.0 1.7 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain CUE PF02845.16 EGD94453.1 - 1.1e-10 41.0 0.1 2.4e-10 39.9 0.1 1.6 1 0 0 1 1 1 1 CUE domain MCC-bdg_PDZ PF10506.9 EGD94453.1 - 0.01 15.8 0.0 0.041 13.9 0.0 2.0 2 0 0 2 2 2 0 PDZ domain of MCC-2 bdg protein for Usher syndrome Ribosomal_S10 PF00338.22 EGD94454.1 - 9.9e-27 93.1 0.3 1.2e-26 92.8 0.3 1.0 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e zf-CCCH_4 PF18044.1 EGD94455.1 - 7.5e-09 35.2 2.5 1.5e-08 34.3 2.5 1.5 1 0 0 1 1 1 1 CCCH-type zinc finger zf-CCCH PF00642.24 EGD94455.1 - 6.4e-06 25.9 2.7 1.4e-05 24.9 2.7 1.6 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 EGD94455.1 - 8.9e-06 25.6 6.3 1.8e-05 24.6 6.3 1.5 1 0 0 1 1 1 1 Zinc finger domain Torus PF16131.5 EGD94455.1 - 0.049 14.3 1.1 0.11 13.2 1.1 1.6 1 0 0 1 1 1 0 Torus domain zf-CCCH_2 PF14608.6 EGD94455.1 - 0.096 13.2 1.3 0.22 12.0 1.3 1.7 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger ELYS PF13934.6 EGD94456.1 - 4.7e-66 222.9 0.2 6.6e-66 222.4 0.2 1.2 1 0 0 1 1 1 1 Nuclear pore complex assembly Peptidase_M75 PF09375.10 EGD94456.1 - 0.076 12.5 0.0 0.11 11.9 0.0 1.2 1 0 0 1 1 1 0 Imelysin SMC_N PF02463.19 EGD94457.1 - 1.3e-65 221.0 38.3 6.5e-65 218.6 38.3 2.6 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 EGD94457.1 - 1.8e-24 86.3 0.1 1.2e-23 83.6 0.0 2.5 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 EGD94457.1 - 2.3e-12 47.3 0.1 4.8e-05 23.3 0.0 3.0 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 EGD94457.1 - 1.9e-09 37.8 14.3 1.9e-09 37.8 14.3 3.8 2 2 1 3 3 3 1 AAA ATPase domain Tektin PF03148.14 EGD94457.1 - 0.00024 20.0 16.1 0.00024 20.0 16.1 5.4 3 2 1 5 5 5 2 Tektin family AAA_29 PF13555.6 EGD94457.1 - 0.00068 19.3 0.0 0.0014 18.3 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain Fib_alpha PF08702.10 EGD94457.1 - 0.0052 17.0 8.0 0.0052 17.0 8.0 6.9 2 2 2 6 6 6 2 Fibrinogen alpha/beta chain family ATG16 PF08614.11 EGD94457.1 - 0.0056 16.9 18.9 0.0056 16.9 18.9 7.6 4 2 3 7 7 7 2 Autophagy protein 16 (ATG16) RT_RNaseH PF17917.1 EGD94457.1 - 0.57 10.5 6.8 0.85 9.9 0.1 3.4 3 0 0 3 3 3 0 RNase H-like domain found in reverse transcriptase Fungal_trans PF04082.18 EGD94458.1 - 4.7e-11 42.2 0.3 1.5e-10 40.6 0.3 1.8 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EGD94458.1 - 4.9e-08 33.0 4.8 9.3e-08 32.1 4.8 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CDC45 PF02724.14 EGD94458.1 - 0.54 8.5 6.7 0.79 7.9 6.7 1.2 1 0 0 1 1 1 0 CDC45-like protein Trypan_PARP PF05887.11 EGD94458.1 - 9.8 6.2 13.2 23 4.9 13.2 1.5 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Suc_Fer-like PF06999.12 EGD94459.1 - 4.3e-69 232.3 0.0 5.1e-69 232.1 0.0 1.1 1 0 0 1 1 1 1 Sucrase/ferredoxin-like Ribonuc_L-PSP PF01042.21 EGD94460.1 - 2.7e-10 40.3 0.1 4.5e-10 39.6 0.1 1.3 1 1 0 1 1 1 1 Endoribonuclease L-PSP WD40 PF00400.32 EGD94461.1 - 8.6e-06 26.4 4.5 0.39 11.7 0.1 4.5 4 0 0 4 4 4 2 WD domain, G-beta repeat Sec62 PF03839.16 EGD94461.1 - 0.71 9.3 7.3 1.3 8.5 7.3 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 RNA_pol_N PF01194.17 EGD94462.1 - 3.5e-31 107.3 1.4 4e-31 107.1 1.4 1.0 1 0 0 1 1 1 1 RNA polymerases N / 8 kDa subunit Chordopox_RPO7 PF05864.12 EGD94462.1 - 0.029 14.6 0.6 0.049 13.9 0.6 1.4 1 1 0 1 1 1 0 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7) GCIP PF13324.6 EGD94463.1 - 0.37 10.4 3.5 4.9 6.7 0.0 2.9 3 0 0 3 3 3 0 Grap2 and cyclin-D-interacting Fer4_13 PF13370.6 EGD94463.1 - 1.3 9.6 3.7 10 6.7 0.0 3.7 3 2 1 4 4 4 0 4Fe-4S single cluster domain of Ferredoxin I Sugar_tr PF00083.24 EGD94464.1 - 4.2e-111 372.0 25.7 4.9e-111 371.8 25.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EGD94464.1 - 4.7e-24 85.0 39.2 2.7e-15 56.2 12.1 2.1 1 1 0 2 2 2 2 Major Facilitator Superfamily DIOX_N PF14226.6 EGD94465.1 - 1.4e-34 119.3 0.0 1.1e-32 113.3 0.0 2.5 2 0 0 2 2 2 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EGD94465.1 - 1.7e-14 54.1 0.0 3.9e-14 53.0 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily GxGYxYP_C PF14323.6 EGD94465.1 - 0.046 13.6 0.0 0.092 12.6 0.0 1.4 1 0 0 1 1 1 0 GxGYxYP putative glycoside hydrolase C-terminal domain MFS_1 PF07690.16 EGD94466.1 - 1.2e-36 126.4 51.7 1.5e-36 126.1 48.7 2.4 2 1 0 2 2 2 1 Major Facilitator Superfamily DUF2254 PF10011.9 EGD94466.1 - 0.0011 17.8 0.0 0.0024 16.8 0.0 1.5 1 0 0 1 1 1 1 Predicted membrane protein (DUF2254) LacY_symp PF01306.19 EGD94466.1 - 0.0018 17.1 0.8 0.0018 17.1 0.8 2.6 2 1 1 3 3 3 1 LacY proton/sugar symporter Sarcolipin PF05366.11 EGD94466.1 - 0.058 13.1 0.1 0.15 11.7 0.1 1.7 1 0 0 1 1 1 0 Sarcolipin CcmD PF04995.14 EGD94466.1 - 4.4 7.5 8.0 2 8.5 0.3 3.4 3 0 0 3 3 3 0 Heme exporter protein D (CcmD) DNA_primase_S PF01896.19 EGD94467.1 - 1.6e-60 204.2 0.1 2.8e-60 203.4 0.1 1.4 1 0 0 1 1 1 1 DNA primase small subunit TRAP_alpha PF03896.16 EGD94467.1 - 0.43 9.7 3.9 0.71 9.0 3.9 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit CDC27 PF09507.10 EGD94467.1 - 1.2 8.4 24.0 0.039 13.4 18.1 1.4 2 0 0 2 2 2 0 DNA polymerase subunit Cdc27 MAM33 PF02330.16 EGD94468.1 - 1.1e-74 250.9 1.2 1.3e-74 250.7 1.2 1.1 1 0 0 1 1 1 1 Mitochondrial glycoprotein DUF3567 PF12091.8 EGD94468.1 - 0.16 12.1 0.5 0.99 9.6 0.3 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF3567) cobW PF02492.19 EGD94469.1 - 1.1e-47 161.9 6.2 1.9e-36 125.3 1.1 2.2 1 1 1 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.14 EGD94469.1 - 9.2e-22 76.8 0.1 1.8e-17 63.1 0.0 2.9 3 0 0 3 3 3 2 Cobalamin synthesis protein cobW C-terminal domain MobB PF03205.14 EGD94469.1 - 0.0072 16.2 0.1 0.017 15.0 0.1 1.7 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_16 PF13191.6 EGD94469.1 - 0.013 15.9 0.4 0.036 14.5 0.4 1.9 1 1 0 1 1 1 0 AAA ATPase domain AAA_33 PF13671.6 EGD94469.1 - 0.023 14.8 0.0 0.17 12.0 0.0 2.3 2 0 0 2 2 2 0 AAA domain TsaE PF02367.17 EGD94469.1 - 0.05 13.6 0.0 0.12 12.4 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE MeaB PF03308.16 EGD94469.1 - 0.054 12.5 0.4 2.4 7.1 0.0 2.4 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Viral_helicase1 PF01443.18 EGD94469.1 - 0.11 12.2 0.1 0.32 10.7 0.1 1.8 1 1 1 2 2 2 0 Viral (Superfamily 1) RNA helicase T2SSE PF00437.20 EGD94469.1 - 0.12 11.5 0.8 0.16 11.0 0.0 1.6 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_29 PF13555.6 EGD94469.1 - 0.15 11.8 0.1 0.41 10.4 0.1 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain Tma16 PF11176.8 EGD94470.1 - 3.3e-49 166.5 3.0 4.2e-49 166.2 3.0 1.1 1 0 0 1 1 1 1 Translation machinery-associated protein 16 XPG_N PF00752.17 EGD94471.1 - 1.3e-23 83.4 0.0 1.7e-22 79.8 0.0 2.5 3 0 0 3 3 3 1 XPG N-terminal domain XPG_I PF00867.18 EGD94471.1 - 2.5e-22 79.0 0.0 5.4e-22 78.0 0.0 1.6 1 0 0 1 1 1 1 XPG I-region XPG_I_2 PF12813.7 EGD94471.1 - 0.0048 16.4 0.0 0.0086 15.6 0.0 1.4 1 0 0 1 1 1 1 XPG domain containing TPR_14 PF13428.6 EGD94471.1 - 0.14 13.0 0.0 0.38 11.7 0.0 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_2 PF07719.17 EGD94471.1 - 0.15 12.3 0.0 0.37 11.0 0.0 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat Fig1 PF12351.8 EGD94472.1 - 1.5e-58 197.9 4.3 1.5e-58 197.9 4.3 1.9 2 0 0 2 2 2 1 Ca2+ regulator and membrane fusion protein Fig1 SUR7 PF06687.12 EGD94472.1 - 2.9e-06 27.1 9.0 4.8e-06 26.3 9.0 1.3 1 1 0 1 1 1 1 SUR7/PalI family MLTD_N PF06474.12 EGD94472.1 - 0.89 9.8 7.0 0.35 11.1 3.0 2.3 2 0 0 2 2 2 0 MltD lipid attachment motif DUF898 PF05987.13 EGD94472.1 - 7.8 5.4 11.1 0.61 9.1 5.5 1.7 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF898) HAD_SAK_1 PF10307.9 EGD94475.1 - 1.7e-79 266.4 0.0 5.3e-79 264.7 0.0 1.7 2 0 0 2 2 2 1 HAD domain family 1 in Swiss Army Knife RNA repair proteins DUF4719 PF15843.5 EGD94475.1 - 4.7 7.3 12.5 10 6.2 12.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4719) zf-RING_2 PF13639.6 EGD94476.1 - 4.5e-08 33.3 9.2 8.1e-08 32.5 9.2 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 EGD94476.1 - 2.1e-05 24.3 8.7 3.3e-05 23.6 8.7 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EGD94476.1 - 2.5e-05 24.0 8.7 4e-05 23.4 8.7 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EGD94476.1 - 0.00011 22.4 8.8 0.00043 20.5 8.8 2.0 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 EGD94476.1 - 0.00011 21.9 8.3 0.00021 21.1 8.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EGD94476.1 - 0.56 10.0 7.0 1.2 8.9 7.0 1.5 1 0 0 1 1 1 0 RING-like zinc finger Drc1-Sld2 PF11719.8 EGD94477.1 - 9.6e-83 279.2 22.6 1.1e-82 279.0 22.6 1.0 1 0 0 1 1 1 1 DNA replication and checkpoint protein Tli4_N PF18443.1 EGD94477.1 - 7.4 6.9 7.4 0.44 10.9 0.4 2.4 2 1 1 3 3 3 0 Tle cognate immunity protein 4 N-terminal domain 2-oxoacid_dh PF00198.23 EGD94478.1 - 4.3e-81 271.8 0.0 8e-81 270.9 0.0 1.4 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 EGD94478.1 - 8.9e-16 57.5 1.4 8.9e-16 57.5 1.4 1.8 2 0 0 2 2 2 1 Biotin-requiring enzyme SAGA-Tad1 PF12767.7 EGD94478.1 - 0.069 12.9 2.8 0.039 13.7 0.9 1.7 2 0 0 2 2 2 0 Transcriptional regulator of RNA polII, SAGA, subunit GCV_H PF01597.19 EGD94478.1 - 0.092 12.6 0.5 0.21 11.5 0.5 1.6 1 0 0 1 1 1 0 Glycine cleavage H-protein FAP PF07174.11 EGD94478.1 - 1.8 7.9 13.0 2.8 7.3 13.0 1.2 1 0 0 1 1 1 0 Fibronectin-attachment protein (FAP) Presenilin PF01080.17 EGD94478.1 - 1.8 7.2 4.3 2.6 6.7 4.3 1.1 1 0 0 1 1 1 0 Presenilin Ndc1_Nup PF09531.10 EGD94478.1 - 4.8 5.7 6.6 7.2 5.2 6.6 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Complex1_LYR PF05347.15 EGD94479.1 - 3.8e-06 26.8 0.5 6.2e-06 26.2 0.5 1.3 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Histone_H2A_C PF16211.5 EGD94480.1 - 4.7e-18 64.6 0.5 8.6e-18 63.8 0.5 1.4 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.24 EGD94480.1 - 4.5e-16 59.4 0.0 5.7e-16 59.1 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EGD94480.1 - 3.6e-05 24.0 0.0 4.8e-05 23.6 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EGD94481.1 - 1.9e-16 60.6 0.5 2.5e-16 60.2 0.5 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EGD94481.1 - 0.058 13.7 0.0 0.058 13.7 0.0 1.8 2 0 0 2 2 2 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Endomucin PF07010.12 EGD94481.1 - 0.11 12.5 3.9 0.13 12.3 3.9 1.1 1 0 0 1 1 1 0 Endomucin Peptidase_C54 PF03416.19 EGD94482.1 - 7.8e-99 330.6 0.0 1.4e-98 329.8 0.0 1.4 2 0 0 2 2 2 1 Peptidase family C54 R3H PF01424.22 EGD94483.1 - 1e-11 44.6 0.0 2.6e-11 43.3 0.0 1.7 1 0 0 1 1 1 1 R3H domain G-patch PF01585.23 EGD94483.1 - 6.5e-09 35.5 0.4 1.5e-08 34.4 0.4 1.7 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 EGD94483.1 - 0.0033 17.5 0.2 0.0033 17.5 0.2 2.6 4 0 0 4 4 4 1 G-patch domain Pet20 PF08692.10 EGD94483.1 - 0.55 10.9 2.2 0.64 10.7 0.2 2.1 2 0 0 2 2 2 0 Mitochondrial protein Pet20 BNIP3 PF06553.12 EGD94483.1 - 5.7 6.6 15.7 0.034 13.8 6.4 1.9 2 0 0 2 2 2 0 BNIP3 DnaJ PF00226.31 EGD94484.1 - 3.4e-25 88.0 0.3 9.8e-25 86.5 0.3 1.9 1 0 0 1 1 1 1 DnaJ domain zf-met PF12874.7 EGD94484.1 - 2.6e-12 46.7 7.5 9.1e-09 35.4 2.7 2.6 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EGD94484.1 - 1.4e-11 44.4 9.7 9.3e-10 38.5 6.5 2.5 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 EGD94484.1 - 6.8e-10 39.2 6.6 0.00022 21.5 1.8 2.4 2 0 0 2 2 2 2 C2H2 type zinc-finger (2 copies) zf-C2H2 PF00096.26 EGD94484.1 - 5.7e-07 29.7 6.1 0.012 16.0 0.4 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EGD94484.1 - 1.3e-06 28.7 4.5 0.016 16.0 0.4 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger Actin_micro PF17003.5 EGD94484.1 - 0.00054 19.2 0.6 0.21 10.8 0.1 2.2 2 0 0 2 2 2 2 Putative actin-like family DUF3449 PF11931.8 EGD94484.1 - 0.0028 17.5 1.9 0.015 15.1 0.2 2.9 3 0 0 3 3 3 1 Domain of unknown function (DUF3449) zf-C2H2_6 PF13912.6 EGD94484.1 - 0.0086 16.1 9.4 0.72 9.9 0.5 2.5 2 0 0 2 2 2 2 C2H2-type zinc finger LIM PF00412.22 EGD94484.1 - 0.01 16.1 1.9 1.7 8.9 0.6 2.4 2 0 0 2 2 2 1 LIM domain zf-C2H2_3rep PF18868.1 EGD94484.1 - 0.01 16.5 2.1 1.9 9.2 0.1 2.7 2 0 0 2 2 2 0 Zinc finger C2H2-type, 3 repeats zf-BED PF02892.15 EGD94484.1 - 0.13 12.3 0.4 24 5.0 0.2 2.4 2 0 0 2 2 2 0 BED zinc finger DUF2256 PF10013.9 EGD94484.1 - 0.16 12.1 0.7 21 5.3 0.1 2.4 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2256) zf-H2C2_2 PF13465.6 EGD94484.1 - 0.37 11.3 1.5 5.8 7.5 0.3 2.5 2 0 0 2 2 2 0 Zinc-finger double domain MRNIP PF15749.5 EGD94484.1 - 2.9 8.6 11.9 0.086 13.6 3.7 2.6 2 1 1 3 3 2 0 MRN-interacting protein Choline_kin_N PF04428.14 EGD94485.1 - 0.05 13.3 0.0 0.093 12.4 0.0 1.5 1 0 0 1 1 1 0 Choline kinase N terminus YccV-like PF08755.11 EGD94486.1 - 6e-30 103.7 0.3 2.6e-29 101.6 0.1 2.1 2 0 0 2 2 2 1 Hemimethylated DNA-binding protein YccV like Transglut_core2 PF13369.6 EGD94486.1 - 8.5e-15 54.7 0.0 1.4e-14 53.9 0.0 1.4 1 0 0 1 1 1 1 Transglutaminase-like superfamily F-box-like PF12937.7 EGD94486.1 - 7.6e-06 25.7 0.0 1.8e-05 24.5 0.0 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EGD94486.1 - 0.0012 18.7 0.0 0.0029 17.4 0.0 1.7 1 0 0 1 1 1 1 F-box domain Elongin_A PF06881.11 EGD94486.1 - 0.0035 17.8 0.1 0.0072 16.8 0.1 1.4 1 0 0 1 1 1 1 RNA polymerase II transcription factor SIII (Elongin) subunit A 23S_rRNA_IVP PF05635.11 EGD94486.1 - 0.022 15.0 0.1 0.069 13.5 0.1 1.8 1 0 0 1 1 1 0 23S rRNA-intervening sequence protein SPX PF03105.19 EGD94487.1 - 1.7e-46 159.9 0.3 3.6e-46 158.8 0.3 1.5 1 1 0 1 1 1 1 SPX domain zf-C3HC4_3 PF13920.6 EGD94487.1 - 8.7e-07 28.7 9.3 1.6e-06 27.9 9.3 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EGD94487.1 - 5.4e-06 26.5 10.5 5.4e-06 26.5 10.5 2.1 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 EGD94487.1 - 1.4e-05 24.9 10.3 3.6e-05 23.6 10.3 1.8 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 EGD94487.1 - 2.3e-05 24.2 10.8 5.7e-05 22.9 10.8 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EGD94487.1 - 0.00015 22.0 12.5 0.00036 20.8 12.5 1.6 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EGD94487.1 - 0.00028 20.7 12.1 0.00069 19.4 12.1 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EGD94487.1 - 0.0015 18.5 10.9 0.0041 17.1 10.9 1.8 1 0 0 1 1 1 1 RING-type zinc-finger zf-ANAPC11 PF12861.7 EGD94487.1 - 0.0096 16.0 3.4 0.021 14.9 3.4 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.6 EGD94487.1 - 0.013 15.4 9.9 0.045 13.6 10.1 1.8 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 zf-RING_4 PF14570.6 EGD94487.1 - 0.026 14.3 3.4 0.026 14.3 3.4 1.9 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain TerY_C PF15616.6 EGD94487.1 - 0.08 13.0 0.8 0.17 12.0 0.8 1.5 1 0 0 1 1 1 0 TerY-C metal binding domain zf-rbx1 PF12678.7 EGD94487.1 - 0.41 11.0 9.8 1.4 9.3 9.8 1.9 1 1 0 1 1 1 0 RING-H2 zinc finger domain zf-P11 PF03854.14 EGD94487.1 - 0.46 10.2 8.2 12 5.7 8.5 2.3 1 1 1 2 2 2 0 P-11 zinc finger Peptidase_C12 PF01088.21 EGD94488.1 - 1.5e-63 214.4 0.1 2.3e-63 213.7 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 UCH_C PF18031.1 EGD94488.1 - 0.074 13.0 1.6 0.21 11.5 1.6 1.8 1 0 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolases I-set PF07679.16 EGD94489.1 - 0.00088 19.3 0.0 0.37 10.9 0.0 3.9 5 0 0 5 5 5 1 Immunoglobulin I-set domain DUF1918 PF08940.11 EGD94489.1 - 0.0018 17.8 0.0 11 5.8 0.0 4.2 4 0 0 4 4 4 3 Domain of unknown function (DUF1918) Nrap_D5 PF17406.2 EGD94490.1 - 3.3e-51 173.3 0.6 6.9e-51 172.2 0.2 1.8 2 0 0 2 2 2 1 Nrap protein PAP/OAS1-like domain 5 Nrap_D2 PF17403.2 EGD94490.1 - 7.8e-50 168.6 0.0 1.6e-47 161.1 0.0 2.6 2 0 0 2 2 2 2 Nrap protein PAP/OAS-like domain Nrap_D4 PF17405.2 EGD94490.1 - 1.4e-41 142.2 0.4 2.6e-41 141.3 0.4 1.4 1 0 0 1 1 1 1 Nrap protein nucleotidyltransferase domain 4 Nrap PF03813.14 EGD94490.1 - 2.5e-41 141.3 0.2 4.3e-41 140.5 0.2 1.4 1 0 0 1 1 1 1 Nrap protein domain 1 Nrap_D3 PF17404.2 EGD94490.1 - 1.3e-40 139.1 0.0 2.7e-40 138.0 0.0 1.5 1 0 0 1 1 1 1 Nrap protein domain 3 Nrap_D6 PF17407.2 EGD94490.1 - 1.3e-27 96.6 0.0 3.1e-27 95.4 0.0 1.7 1 0 0 1 1 1 1 Nrap protein domain 6 Fibroin_P25 PF07294.11 EGD94490.1 - 0.064 13.3 0.1 0.13 12.3 0.1 1.4 1 0 0 1 1 1 0 Fibroin P25 Cys_Met_Meta_PP PF01053.20 EGD94491.1 - 1.6e-31 109.2 0.0 2.1e-31 108.8 0.0 1.1 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Mt_ATP_synt PF15704.5 EGD94491.1 - 0.0032 17.4 0.1 0.0056 16.6 0.1 1.3 1 0 0 1 1 1 1 Mitochondrial ATP synthase subunit MRP-L20 PF12824.7 EGD94493.1 - 3.1e-58 196.6 2.7 3.5e-58 196.4 2.7 1.0 1 0 0 1 1 1 1 Mitochondrial ribosomal protein subunit L20 Neugrin PF06413.11 EGD94493.1 - 0.0077 16.3 0.0 0.019 15.0 0.0 1.6 1 0 0 1 1 1 1 Neugrin Pkinase PF00069.25 EGD94494.1 - 1.6e-05 24.4 0.0 2.6e-05 23.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.23 EGD94494.1 - 0.00031 20.7 0.1 0.00031 20.7 0.1 2.7 3 1 1 4 4 4 1 Phosphotransferase enzyme family HSDR_N_2 PF13588.6 EGD94494.1 - 0.0009 19.2 0.0 0.32 11.0 0.0 2.6 1 1 1 2 2 2 2 Type I restriction enzyme R protein N terminus (HSDR_N) Kdo PF06293.14 EGD94494.1 - 0.01 15.2 0.1 0.019 14.4 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 EGD94494.1 - 0.021 14.4 0.0 0.036 13.7 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase Pkinase_Tyr PF07714.17 EGD94494.1 - 0.11 11.7 0.0 0.19 11.0 0.0 1.2 1 0 0 1 1 1 0 Protein tyrosine kinase DUF5596 PF18082.1 EGD94495.1 - 0.12 12.2 0.0 0.2 11.5 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5596) Peptidase_M20 PF01546.28 EGD94496.1 - 3.5e-32 111.8 0.0 4.6e-32 111.4 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 EGD94496.1 - 2.3e-12 46.8 0.0 3.6e-12 46.2 0.0 1.3 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 EGD94496.1 - 0.025 14.3 0.0 0.054 13.2 0.0 1.5 1 0 0 1 1 1 0 Peptidase family M28 CobS_N PF12556.8 EGD94496.1 - 0.069 12.9 0.0 0.14 11.9 0.0 1.5 1 0 0 1 1 1 0 Cobaltochelatase CobS subunit N terminal Methyltransf_25 PF13649.6 EGD94498.1 - 4.3e-09 37.0 0.0 1e-08 35.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EGD94498.1 - 9.8e-06 25.4 0.0 1.6e-05 24.8 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EGD94498.1 - 0.00012 22.8 0.0 0.00027 21.6 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EGD94498.1 - 0.00019 22.0 0.0 0.00043 20.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain adh_short PF00106.25 EGD94499.1 - 4e-26 91.7 0.0 5.9e-26 91.1 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EGD94499.1 - 1.7e-15 57.3 0.0 6.9e-15 55.2 0.0 1.8 1 1 1 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EGD94499.1 - 1e-05 25.5 0.0 1.5e-05 25.0 0.0 1.3 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 EGD94499.1 - 0.00037 19.7 0.0 0.0005 19.3 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Phageshock_PspD PF09584.10 EGD94499.1 - 0.13 12.3 0.1 0.24 11.4 0.1 1.4 1 0 0 1 1 1 0 Phage shock protein PspD (Phageshock_PspD) Fanconi_A_N PF15865.5 EGD94499.1 - 0.23 10.8 0.0 0.36 10.2 0.0 1.2 1 0 0 1 1 1 0 Fanconi anaemia group A protein N terminus Eno-Rase_NADH_b PF12242.8 EGD94499.1 - 0.28 11.0 0.1 0.28 11.0 0.1 1.9 2 0 0 2 2 2 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase AMP-binding PF00501.28 EGD94500.1 - 6.4e-67 226.0 0.0 9e-67 225.5 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme Condensation PF00668.20 EGD94500.1 - 5.7e-31 107.7 0.0 1.2e-30 106.6 0.0 1.5 1 0 0 1 1 1 1 Condensation domain PP-binding PF00550.25 EGD94500.1 - 9.3e-09 35.5 0.9 2.2e-08 34.3 0.4 2.0 2 0 0 2 2 2 1 Phosphopantetheine attachment site p450 PF00067.22 EGD94501.1 - 1.7e-66 224.9 0.0 2.3e-66 224.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF4296 PF14129.6 EGD94501.1 - 0.11 13.1 0.1 0.23 12.1 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4296) NmrA PF05368.13 EGD94502.1 - 1e-42 146.3 0.0 1.4e-42 145.8 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EGD94502.1 - 4.5e-16 59.3 0.0 6.1e-16 58.9 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EGD94502.1 - 0.00085 18.9 0.0 0.0013 18.2 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Semialdhyde_dh PF01118.24 EGD94502.1 - 0.001 19.5 0.0 0.002 18.6 0.0 1.5 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain TrkA_N PF02254.18 EGD94502.1 - 0.031 14.5 0.0 0.055 13.7 0.0 1.3 1 0 0 1 1 1 0 TrkA-N domain F420_oxidored PF03807.17 EGD94502.1 - 0.055 14.0 0.1 0.22 12.1 0.1 1.9 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent DapB_N PF01113.20 EGD94502.1 - 0.16 12.1 0.0 0.33 11.1 0.0 1.5 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus AMP-binding PF00501.28 EGD94503.1 - 6.6e-69 232.5 0.0 1.1e-68 231.8 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme NAD_binding_4 PF07993.12 EGD94503.1 - 5.4e-56 189.6 0.0 8e-56 189.1 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein PP-binding PF00550.25 EGD94503.1 - 1e-12 48.2 0.2 2e-12 47.2 0.2 1.6 1 0 0 1 1 1 1 Phosphopantetheine attachment site Epimerase PF01370.21 EGD94503.1 - 3.8e-07 29.8 0.0 1.3e-06 28.1 0.0 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EGD94503.1 - 1.5e-05 24.2 0.0 3.3e-05 23.0 0.0 1.5 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family AMP-binding_C PF13193.6 EGD94503.1 - 0.094 13.7 0.0 0.25 12.4 0.0 1.8 1 0 0 1 1 1 0 AMP-binding enzyme C-terminal domain Methyltransf_2 PF00891.18 EGD94504.1 - 3e-34 118.2 0.0 4.4e-34 117.6 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_12 PF08242.12 EGD94504.1 - 0.00042 21.0 0.0 0.00078 20.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EGD94504.1 - 0.0035 18.0 0.0 0.0086 16.8 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EGD94505.1 - 1.4e-08 35.3 0.0 3e-08 34.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EGD94505.1 - 1.1e-06 29.3 0.0 2e-06 28.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EGD94505.1 - 1.8e-05 25.3 0.0 4.6e-05 24.0 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EGD94505.1 - 0.00029 20.7 0.0 0.00064 19.5 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EGD94505.1 - 0.021 14.7 0.0 0.41 10.5 0.0 2.2 1 1 0 1 1 1 0 Methyltransferase domain GidB PF02527.15 EGD94505.1 - 0.044 13.1 0.0 0.071 12.4 0.0 1.2 1 0 0 1 1 1 0 rRNA small subunit methyltransferase G MFS_1 PF07690.16 EGD94506.1 - 7.2e-47 160.0 29.8 2e-40 138.8 25.0 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 EGD94506.1 - 7.7e-09 34.9 11.6 0.00014 20.9 4.4 3.5 2 1 1 3 3 3 3 MFS_1 like family OATP PF03137.20 EGD94506.1 - 4.5e-07 28.6 11.8 3.5e-06 25.6 3.5 3.5 2 1 0 3 3 3 1 Organic Anion Transporter Polypeptide (OATP) family DUF2627 PF11118.8 EGD94506.1 - 0.29 11.8 3.4 1.1 9.8 0.1 3.0 2 1 0 2 2 2 0 Protein of unknown function (DUF2627) UPRTase PF14681.6 EGD94507.1 - 1.2e-22 80.4 0.0 1.9e-22 79.7 0.0 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase AAA_17 PF13207.6 EGD94507.1 - 1.6e-22 80.4 0.0 2.1e-21 76.8 0.0 2.2 2 0 0 2 2 2 1 AAA domain HAD PF12710.7 EGD94507.1 - 3.6e-14 53.6 0.0 6e-14 52.9 0.0 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase AAA_18 PF13238.6 EGD94507.1 - 5.1e-07 30.3 0.0 1.2e-06 29.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain KAP_NTPase PF07693.14 EGD94507.1 - 1.9e-05 24.1 0.0 4.4e-05 22.9 0.0 1.5 2 0 0 2 2 2 1 KAP family P-loop domain AAA_16 PF13191.6 EGD94507.1 - 8.6e-05 23.0 0.0 0.00019 21.9 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain G-alpha PF00503.20 EGD94507.1 - 0.0028 16.9 0.0 0.0038 16.4 0.0 1.2 1 0 0 1 1 1 1 G-protein alpha subunit AAA_24 PF13479.6 EGD94507.1 - 0.0035 17.1 0.0 0.0057 16.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 EGD94507.1 - 0.0043 16.3 0.0 0.0074 15.6 0.0 1.3 1 0 0 1 1 1 1 Zeta toxin AAA_22 PF13401.6 EGD94507.1 - 0.0058 16.9 0.0 0.016 15.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain ATPase_2 PF01637.18 EGD94507.1 - 0.0094 15.9 0.0 0.016 15.1 0.0 1.3 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea SRP54 PF00448.22 EGD94507.1 - 0.011 15.4 0.0 0.018 14.7 0.0 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain NB-ARC PF00931.22 EGD94507.1 - 0.011 14.9 0.0 0.032 13.4 0.0 1.7 1 0 0 1 1 1 0 NB-ARC domain Hydrolase_3 PF08282.12 EGD94507.1 - 0.016 15.0 0.0 0.028 14.1 0.0 1.3 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase AAA_33 PF13671.6 EGD94507.1 - 0.016 15.3 0.0 0.036 14.2 0.0 1.6 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 EGD94507.1 - 0.018 15.6 0.0 0.037 14.5 0.0 1.5 1 0 0 1 1 1 0 ABC transporter cobW PF02492.19 EGD94507.1 - 0.03 13.9 0.1 0.11 12.1 0.1 1.9 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain APS_kinase PF01583.20 EGD94507.1 - 0.03 14.2 0.0 0.047 13.6 0.0 1.3 1 0 0 1 1 1 0 Adenylylsulphate kinase MobB PF03205.14 EGD94507.1 - 0.033 14.1 0.1 0.068 13.1 0.1 1.5 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B NACHT PF05729.12 EGD94507.1 - 0.037 14.0 0.0 0.069 13.1 0.0 1.4 1 0 0 1 1 1 0 NACHT domain S6PP PF05116.13 EGD94507.1 - 0.052 13.1 0.3 0.13 11.8 0.0 1.8 2 0 0 2 2 2 0 Sucrose-6F-phosphate phosphohydrolase PduV-EutP PF10662.9 EGD94507.1 - 0.059 13.1 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation SKI PF01202.22 EGD94507.1 - 0.07 13.2 0.0 0.32 11.1 0.0 2.0 2 0 0 2 2 2 0 Shikimate kinase Pox_A32 PF04665.12 EGD94507.1 - 0.072 12.5 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 Poxvirus A32 protein AAA_28 PF13521.6 EGD94507.1 - 0.087 13.1 0.0 0.31 11.3 0.0 1.9 1 0 0 1 1 1 0 AAA domain PRK PF00485.18 EGD94507.1 - 0.097 12.4 0.0 0.17 11.6 0.0 1.4 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family RsgA_GTPase PF03193.16 EGD94507.1 - 0.1 12.5 0.0 0.2 11.6 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase PEPCK_ATP PF01293.20 EGD94507.1 - 0.1 11.2 0.0 0.16 10.6 0.0 1.2 1 0 0 1 1 1 0 Phosphoenolpyruvate carboxykinase AAA_5 PF07728.14 EGD94507.1 - 0.11 12.5 0.0 0.68 9.9 0.0 2.2 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_30 PF13604.6 EGD94507.1 - 0.11 12.1 0.0 0.25 11.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 EGD94507.1 - 0.15 12.5 0.0 0.33 11.4 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 EGD94507.1 - 0.15 12.1 0.0 0.33 11.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain dNK PF01712.19 EGD94507.1 - 0.2 11.5 0.0 0.95 9.3 0.0 2.0 2 0 0 2 2 2 0 Deoxynucleoside kinase PRELI PF04707.14 EGD94508.1 - 1.8e-23 83.1 0.0 1.8e-20 73.3 0.0 2.2 2 0 0 2 2 2 2 PRELI-like family His_Phos_1 PF00300.22 EGD94509.1 - 6.2e-39 133.7 0.1 7.8e-39 133.4 0.1 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Pkinase PF00069.25 EGD94510.1 - 2.9e-73 246.5 0.0 3.7e-73 246.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD94510.1 - 6.9e-37 127.1 0.0 9.5e-37 126.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase UBA_2 PF08587.11 EGD94510.1 - 2.4e-16 59.6 0.0 5.5e-16 58.4 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin associated domain (UBA) AdenylateSensor PF16579.5 EGD94510.1 - 4.6e-07 30.3 0.1 0.00039 20.9 0.0 2.5 2 0 0 2 2 2 2 Adenylate sensor of SNF1-like protein kinase Kinase-like PF14531.6 EGD94510.1 - 2.2e-06 27.2 0.0 5e-06 26.1 0.0 1.7 1 1 0 1 1 1 1 Kinase-like RIO1 PF01163.22 EGD94510.1 - 0.00019 21.1 0.2 0.00034 20.3 0.2 1.3 1 0 0 1 1 1 1 RIO1 family Haspin_kinase PF12330.8 EGD94510.1 - 0.00084 18.4 0.3 0.0019 17.2 0.3 1.6 1 1 0 1 1 1 1 Haspin like kinase domain YukC PF10140.9 EGD94510.1 - 0.0098 14.8 0.1 0.015 14.2 0.1 1.2 1 0 0 1 1 1 1 WXG100 protein secretion system (Wss), protein YukC APH PF01636.23 EGD94510.1 - 0.015 15.2 0.9 0.058 13.3 0.1 2.2 2 1 0 3 3 3 0 Phosphotransferase enzyme family Kdo PF06293.14 EGD94510.1 - 0.13 11.6 0.1 0.23 10.8 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.11 EGD94510.1 - 0.13 11.3 0.5 0.2 10.7 0.5 1.1 1 0 0 1 1 1 0 Seadornavirus VP7 MARVEL PF01284.23 EGD94511.1 - 6.6e-23 81.3 8.6 8.1e-23 81.0 8.6 1.0 1 0 0 1 1 1 1 Membrane-associating domain Pkinase_fungal PF17667.1 EGD94512.1 - 3.4e-44 151.2 0.0 5.5e-44 150.6 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase His_Phos_1 PF00300.22 EGD94517.1 - 2.9e-12 46.7 0.0 1.4e-11 44.4 0.0 1.9 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Peptidase_M28 PF04389.17 EGD94518.1 - 9.6e-32 110.3 0.2 1.9e-31 109.3 0.2 1.5 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.28 EGD94518.1 - 0.0024 17.6 0.3 0.0049 16.6 0.1 1.7 2 0 0 2 2 2 1 Peptidase family M20/M25/M40 DUF1257 PF06868.11 EGD94518.1 - 0.074 13.3 0.0 0.2 11.9 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1257) Med28 PF11594.8 EGD94518.1 - 0.088 12.9 0.3 0.19 11.8 0.0 1.6 2 0 0 2 2 2 0 Mediator complex subunit 28 L_HMGIC_fpl PF10242.9 EGD94519.1 - 0.019 15.2 1.2 0.019 15.2 1.2 2.4 2 1 0 2 2 2 0 Lipoma HMGIC fusion partner-like protein RRM_1 PF00076.22 EGD94520.1 - 1.2e-51 172.4 0.2 1.7e-19 69.4 0.1 4.8 5 0 0 5 5 5 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EGD94520.1 - 5.6e-37 125.5 0.0 3.6e-30 103.7 0.0 4.3 4 0 0 4 4 4 3 Occluded RNA-recognition motif Nup35_RRM_2 PF14605.6 EGD94520.1 - 2.1e-05 24.4 0.0 0.016 15.2 0.1 3.5 3 0 0 3 3 3 1 Nup53/35/40-type RNA recognition motif DUF1866 PF08952.11 EGD94520.1 - 0.002 18.0 0.0 1 9.2 0.0 2.9 2 1 1 3 3 3 2 Domain of unknown function (DUF1866) Glyco_hydro_30C PF17189.4 EGD94520.1 - 0.0073 16.5 0.4 0.014 15.6 0.4 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 30 beta sandwich domain TPR_14 PF13428.6 EGD94520.1 - 0.0079 16.9 0.1 9.7 7.3 0.0 4.4 3 0 0 3 3 3 1 Tetratricopeptide repeat eIF-3_zeta PF05091.12 EGD94520.1 - 0.47 9.4 7.9 0.92 8.4 7.9 1.4 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Band_3_cyto PF07565.13 EGD94520.1 - 1 9.1 5.7 2.5 7.8 5.7 1.6 1 0 0 1 1 1 0 Band 3 cytoplasmic domain TMEM51 PF15345.6 EGD94520.1 - 1.1 9.1 8.4 2.9 7.7 8.4 1.7 1 0 0 1 1 1 0 Transmembrane protein 51 Spt20 PF12090.8 EGD94520.1 - 1.5 8.4 19.3 0.31 10.6 13.3 2.3 2 0 0 2 2 2 0 Spt20 family DUF2681 PF10883.8 EGD94521.1 - 0.037 14.4 1.2 0.046 14.1 1.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2681) CENP-U PF13097.6 EGD94521.1 - 0.089 12.7 5.8 0.11 12.5 5.8 1.0 1 0 0 1 1 1 0 CENP-A nucleosome associated complex (NAC) subunit DEAD PF00270.29 EGD94523.1 - 6.7e-47 159.5 0.0 1.3e-46 158.6 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EGD94523.1 - 6.9e-25 87.6 0.0 7.1e-24 84.3 0.0 2.5 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 EGD94523.1 - 1e-19 70.5 0.2 2.6e-19 69.2 0.2 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 EGD94523.1 - 0.00088 19.3 0.0 0.0022 18.0 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit SecA_DEAD PF07517.14 EGD94523.1 - 0.044 13.1 0.0 0.06 12.6 0.0 1.3 1 0 0 1 1 1 0 SecA DEAD-like domain Ribosomal_L22 PF00237.19 EGD94524.1 - 2e-28 98.6 0.1 3.6e-28 97.8 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e Oxysterol_BP PF01237.18 EGD94525.1 - 4.2e-48 164.1 0.0 1.7e-45 155.5 0.0 2.7 1 1 0 1 1 1 1 Oxysterol-binding protein Miga PF10265.9 EGD94525.1 - 3.2 6.6 7.0 4.7 6.1 7.0 1.2 1 0 0 1 1 1 0 Mitoguardin Cnd1_N PF12922.7 EGD94526.1 - 1e-57 194.6 0.0 2.7e-57 193.2 0.0 1.8 1 0 0 1 1 1 1 non-SMC mitotic condensation complex subunit 1, N-term Cnd1 PF12717.7 EGD94526.1 - 3e-48 163.9 5.3 1.5e-43 148.6 1.8 3.6 3 0 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 EGD94526.1 - 1.2e-09 37.6 6.2 0.12 12.7 0.0 7.2 6 0 0 6 6 6 2 HEAT repeat HEAT_2 PF13646.6 EGD94526.1 - 2.2e-09 37.6 5.2 0.00064 20.1 0.0 5.4 4 2 2 6 6 6 3 HEAT repeats Adaptin_N PF01602.20 EGD94526.1 - 1.5e-07 30.4 8.9 0.00021 20.0 1.1 4.2 4 0 0 4 4 4 2 Adaptin N terminal region RTP1_C1 PF10363.9 EGD94526.1 - 3.9e-06 27.0 0.7 1.3 9.2 0.0 4.9 3 1 0 3 3 3 2 Required for nuclear transport of RNA pol II C-terminus 1 Cnd3 PF12719.7 EGD94526.1 - 0.00028 20.2 3.1 0.0031 16.8 1.0 3.6 3 1 1 4 4 4 1 Nuclear condensing complex subunits, C-term domain HEAT_EZ PF13513.6 EGD94526.1 - 0.00045 20.7 8.0 0.42 11.2 0.1 5.6 5 0 0 5 5 5 1 HEAT-like repeat VHS PF00790.19 EGD94526.1 - 0.13 12.1 0.4 36 4.2 0.0 3.5 3 0 0 3 3 3 0 VHS domain DUF2967 PF11179.8 EGD94526.1 - 1.4 6.9 5.1 0.34 9.0 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2967) Pkinase PF00069.25 EGD94527.1 - 1.9e-42 145.5 0.0 4.6e-22 78.6 0.0 3.0 3 0 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.17 EGD94527.1 - 6.6e-15 55.1 0.0 5.1e-11 42.3 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase APH PF01636.23 EGD94527.1 - 0.011 15.6 0.0 0.28 11.1 0.0 2.5 2 1 1 3 3 3 0 Phosphotransferase enzyme family Kinase-like PF14531.6 EGD94527.1 - 0.032 13.6 0.0 5.7 6.2 0.0 2.3 2 0 0 2 2 2 0 Kinase-like FTA2 PF13095.6 EGD94527.1 - 0.059 13.0 0.0 0.19 11.3 0.0 1.8 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Pkinase_fungal PF17667.1 EGD94527.1 - 0.12 11.1 0.0 0.18 10.5 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase PCMT PF01135.19 EGD94528.1 - 2.6e-61 207.1 0.0 3.1e-61 206.8 0.0 1.0 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.6 EGD94528.1 - 1.4e-07 31.5 0.0 2.1e-07 30.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EGD94528.1 - 2.3e-06 28.2 0.0 3.9e-06 27.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EGD94528.1 - 3.4e-05 23.7 0.0 4.6e-05 23.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EGD94528.1 - 0.00048 20.8 0.0 0.00074 20.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 EGD94528.1 - 0.00052 20.0 0.0 0.00081 19.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EGD94528.1 - 0.0051 16.4 0.0 0.0086 15.6 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_11 PF08241.12 EGD94528.1 - 0.0091 16.6 0.0 0.016 15.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MetW PF07021.12 EGD94528.1 - 0.015 14.9 0.0 0.022 14.4 0.0 1.2 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW PrmA PF06325.13 EGD94528.1 - 0.032 13.6 0.0 0.042 13.2 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) CMAS PF02353.20 EGD94528.1 - 0.037 13.3 0.0 0.062 12.6 0.0 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_9 PF08003.11 EGD94528.1 - 0.14 11.0 0.0 0.18 10.7 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) DnaJ PF00226.31 EGD94529.1 - 1.7e-22 79.3 1.3 5e-22 77.8 1.3 1.9 1 0 0 1 1 1 1 DnaJ domain TPR_2 PF07719.17 EGD94529.1 - 4e-19 67.1 1.5 0.00034 20.5 0.0 6.7 7 0 0 7 7 6 4 Tetratricopeptide repeat TPR_1 PF00515.28 EGD94529.1 - 1.8e-17 62.3 1.0 9.8e-06 25.2 0.0 6.4 7 0 0 7 7 6 4 Tetratricopeptide repeat TPR_9 PF13371.6 EGD94529.1 - 1.5e-15 57.1 0.4 0.0014 18.7 0.0 4.9 2 1 3 5 5 5 3 Tetratricopeptide repeat TPR_14 PF13428.6 EGD94529.1 - 3.8e-13 49.1 0.5 0.087 13.7 0.1 6.9 3 3 4 7 7 7 3 Tetratricopeptide repeat TPR_19 PF14559.6 EGD94529.1 - 6.6e-12 45.8 2.2 0.011 16.3 0.4 4.8 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 EGD94529.1 - 1.1e-11 44.0 0.1 0.016 15.3 0.0 6.7 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_16 PF13432.6 EGD94529.1 - 8.5e-11 42.3 1.1 1.4e-05 25.6 0.1 4.9 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_11 PF13414.6 EGD94529.1 - 5.9e-09 35.5 1.7 0.042 13.5 0.0 4.5 3 1 1 4 4 4 3 TPR repeat TPR_6 PF13174.6 EGD94529.1 - 1.2e-08 35.0 6.0 4.1 8.2 0.0 7.6 8 0 0 8 8 8 1 Tetratricopeptide repeat TPR_17 PF13431.6 EGD94529.1 - 1.3e-06 28.3 2.6 0.014 15.7 0.0 6.1 7 2 0 7 7 5 1 Tetratricopeptide repeat PknG_TPR PF16918.5 EGD94529.1 - 0.00012 20.9 0.1 0.0061 15.3 0.0 2.8 3 0 0 3 3 3 1 Protein kinase G tetratricopeptide repeat TPR_12 PF13424.6 EGD94529.1 - 0.00043 20.5 1.2 3.3 8.1 0.0 5.1 6 0 0 6 6 5 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EGD94529.1 - 0.00058 20.0 6.6 5.7 7.2 0.0 5.0 4 2 2 6 6 5 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 EGD94529.1 - 0.00078 19.3 0.0 26 5.2 0.0 4.9 5 0 0 5 5 4 0 Tetratricopeptide repeat DUF3856 PF12968.7 EGD94529.1 - 0.0079 16.3 1.7 5.5 7.1 0.0 3.9 3 2 1 4 4 4 1 Domain of Unknown Function (DUF3856) HrpB1_HrpK PF09613.10 EGD94529.1 - 0.019 14.6 0.0 8.7 6.0 0.0 3.3 3 1 1 4 4 4 0 Bacterial type III secretion protein (HrpB1_HrpK) Alkyl_sulf_dimr PF14863.6 EGD94529.1 - 0.044 14.2 1.2 0.61 10.5 0.3 2.9 3 0 0 3 3 3 0 Alkyl sulfatase dimerisation Fis1_TPR_C PF14853.6 EGD94529.1 - 0.098 12.7 2.8 8.5 6.5 0.1 4.0 4 1 0 4 4 4 0 Fis1 C-terminal tetratricopeptide repeat DUF4363 PF14276.6 EGD94529.1 - 0.12 12.5 1.3 0.7 10.0 0.3 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4363) PTS_IIA PF02255.16 EGD94529.1 - 0.15 12.2 6.8 8.2 6.6 0.2 3.0 2 0 0 2 2 2 0 PTS system, Lactose/Cellobiose specific IIA subunit RPT PF13446.6 EGD94529.1 - 0.25 11.3 0.9 5.7 6.9 0.0 3.4 5 0 0 5 5 4 0 A repeated domain in UCH-protein LMBR1 PF04791.16 EGD94529.1 - 0.68 8.8 3.0 1.5 7.6 2.2 1.8 2 0 0 2 2 2 0 LMBR1-like membrane protein PCRF PF03462.18 EGD94530.1 - 5.5e-49 166.7 0.3 1.8e-48 165.0 0.0 2.0 3 0 0 3 3 3 1 PCRF domain RF-1 PF00472.20 EGD94530.1 - 1.3e-33 115.3 1.0 1.3e-33 115.3 1.0 2.0 2 0 0 2 2 2 1 RF-1 domain Abdominal-A PF12407.8 EGD94530.1 - 0.76 9.4 9.1 1.6 8.4 9.1 1.5 1 0 0 1 1 1 0 Homeobox protein Mito_carr PF00153.27 EGD94531.1 - 7.9e-54 179.6 4.0 5.7e-23 80.7 0.1 4.0 4 0 0 4 4 4 4 Mitochondrial carrier protein Helicase_C PF00271.31 EGD94532.1 - 2.9e-27 95.2 1.2 3.5e-27 95.0 0.4 1.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 EGD94532.1 - 1.9e-16 60.3 0.0 2.8e-16 59.8 0.0 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase CMS1 PF14617.6 EGD94532.1 - 0.069 12.5 0.1 0.14 11.5 0.1 1.4 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit SMC_N PF02463.19 EGD94533.1 - 1.1e-22 80.6 0.0 8.2e-11 41.8 0.1 2.2 2 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 EGD94533.1 - 6.3e-15 56.2 42.6 2.4e-13 51.1 14.0 4.5 2 2 1 3 3 3 2 AAA domain AAA_15 PF13175.6 EGD94533.1 - 7e-11 42.4 0.0 7e-11 42.4 0.0 2.5 2 0 0 2 2 2 1 AAA ATPase domain AAA_21 PF13304.6 EGD94533.1 - 3.2e-08 33.7 3.8 8.5e-06 25.8 0.1 3.3 4 0 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EGD94533.1 - 0.0004 20.1 0.0 0.001 18.8 0.0 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain SbcCD_C PF13558.6 EGD94533.1 - 0.004 17.3 0.0 0.012 15.8 0.0 1.8 1 0 0 1 1 1 1 Putative exonuclease SbcCD, C subunit ABC_tran PF00005.27 EGD94533.1 - 0.1 13.1 0.2 0.1 13.1 0.2 4.9 3 2 0 3 3 3 0 ABC transporter RsgA_GTPase PF03193.16 EGD94533.1 - 6.8 6.6 10.9 3 7.7 0.0 3.9 4 0 0 4 4 4 0 RsgA GTPase NUDIX PF00293.28 EGD94534.1 - 6e-13 49.0 0.7 1.1e-12 48.1 0.7 1.4 1 1 0 1 1 1 1 NUDIX domain NUDIX_4 PF14815.6 EGD94534.1 - 0.00014 21.8 0.3 0.0028 17.6 0.3 2.4 1 1 0 1 1 1 1 NUDIX domain Spt20 PF12090.8 EGD94535.1 - 5.6 6.5 13.9 0.59 9.7 7.7 2.4 2 0 0 2 2 2 0 Spt20 family SNARE PF05739.19 EGD94537.1 - 9e-13 48.0 0.1 2.5e-12 46.6 0.1 1.8 1 0 0 1 1 1 1 SNARE domain Syntaxin-5_N PF11416.8 EGD94537.1 - 7.5e-11 41.0 0.4 2.1e-10 39.5 0.4 1.8 1 0 0 1 1 1 1 Syntaxin-5 N-terminal, Sly1p-binding domain KxDL PF10241.9 EGD94537.1 - 0.00011 22.4 2.6 0.19 12.0 0.1 3.5 4 0 0 4 4 4 2 Uncharacterized conserved protein Syntaxin PF00804.25 EGD94537.1 - 0.002 17.8 3.1 0.012 15.3 0.1 2.8 2 1 1 3 3 3 1 Syntaxin Snapin_Pallidin PF14712.6 EGD94537.1 - 0.026 14.9 0.4 22 5.6 0.0 3.2 3 0 0 3 3 3 0 Snapin/Pallidin DUF4988 PF16378.5 EGD94537.1 - 0.076 12.7 1.1 18 4.9 0.1 3.1 3 0 0 3 3 3 0 Domain of unknown function NPV_P10 PF05531.12 EGD94537.1 - 0.079 13.4 2.9 9.5 6.8 0.1 3.3 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein MCPsignal PF00015.21 EGD94537.1 - 0.13 12.1 5.7 0.56 10.0 0.5 3.0 2 1 0 3 3 3 0 Methyl-accepting chemotaxis protein (MCP) signalling domain Syntaxin-18_N PF10496.9 EGD94537.1 - 0.14 12.4 2.3 0.19 12.0 0.1 2.3 3 0 0 3 3 3 0 SNARE-complex protein Syntaxin-18 N-terminus SUR7 PF06687.12 EGD94538.1 - 0.00046 19.9 0.0 0.00067 19.3 0.0 1.1 1 0 0 1 1 1 1 SUR7/PalI family AAA_22 PF13401.6 EGD94539.1 - 0.039 14.2 0.1 2.7 8.3 0.0 2.4 2 0 0 2 2 2 0 AAA domain DUF87 PF01935.17 EGD94539.1 - 0.041 14.0 0.1 11 6.0 0.1 2.3 2 0 0 2 2 2 0 Helicase HerA, central domain Zeta_toxin PF06414.12 EGD94539.1 - 0.13 11.5 0.0 0.26 10.6 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin FtsK_SpoIIIE PF01580.18 EGD94539.1 - 0.15 11.4 0.1 0.25 10.7 0.1 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family Glyco_hydro_18 PF00704.28 EGD94540.1 - 3.2e-20 73.1 0.5 8.9e-20 71.6 0.5 1.6 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 adh_short PF00106.25 EGD94541.1 - 3.1e-35 121.4 0.0 3.8e-35 121.1 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EGD94541.1 - 3.6e-31 108.5 0.0 4.3e-31 108.3 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EGD94541.1 - 1.8e-12 47.5 0.0 2.9e-12 46.9 0.0 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EGD94541.1 - 7.4e-06 25.6 0.1 0.00015 21.3 0.1 2.1 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 EGD94541.1 - 8.1e-05 21.9 0.0 9.1e-05 21.7 0.0 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein DUF1776 PF08643.10 EGD94541.1 - 0.012 15.0 0.0 0.018 14.4 0.0 1.1 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) Ion_trans_2 PF07885.16 EGD94542.1 - 6.4e-24 83.7 24.2 5.2e-14 52.0 7.6 3.3 3 0 0 3 3 3 2 Ion channel GWT1 PF06423.12 EGD94542.1 - 8.5 6.5 7.0 37 4.4 2.7 2.8 2 1 0 2 2 2 0 GWT1 PTR2 PF00854.21 EGD94544.1 - 5.2e-52 177.0 5.3 8.8e-52 176.3 5.3 1.4 1 1 0 1 1 1 1 POT family EBP PF05241.12 EGD94544.1 - 0.26 10.8 5.6 1.2 8.5 4.5 2.3 2 0 0 2 2 2 0 Emopamil binding protein ATPgrasp_N PF18130.1 EGD94545.1 - 1e-18 67.6 0.1 2.2e-18 66.6 0.1 1.6 1 0 0 1 1 1 1 ATP-grasp N-terminal domain ATP-grasp_4 PF13535.6 EGD94545.1 - 3e-13 49.7 0.0 1e-12 48.0 0.0 1.9 2 0 0 2 2 2 1 ATP-grasp domain Dala_Dala_lig_C PF07478.13 EGD94545.1 - 1.8e-07 30.9 0.0 3.4e-07 30.0 0.0 1.4 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus CPSase_L_D2 PF02786.17 EGD94545.1 - 0.00036 20.1 0.0 0.001 18.6 0.0 1.8 2 0 0 2 2 2 1 Carbamoyl-phosphate synthase L chain, ATP binding domain ATP-grasp_3 PF02655.14 EGD94545.1 - 0.0009 19.3 0.0 0.0044 17.1 0.0 2.1 2 0 0 2 2 2 1 ATP-grasp domain RTA1 PF04479.13 EGD94547.1 - 5.3e-73 245.0 8.6 8.4e-73 244.4 8.6 1.3 1 0 0 1 1 1 1 RTA1 like protein DHHC PF01529.20 EGD94547.1 - 0.54 10.4 10.9 1.1 9.4 0.6 3.1 3 0 0 3 3 3 0 DHHC palmitoyltransferase DUF3433 PF11915.8 EGD94548.1 - 1.4e-31 108.8 27.3 3.2e-22 78.8 5.9 3.4 3 0 0 3 3 3 2 Protein of unknown function (DUF3433) Pkinase PF00069.25 EGD94549.1 - 4.6e-24 85.2 0.0 2.2e-23 83.0 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD94549.1 - 1.2e-10 41.1 0.4 2.1e-09 37.0 0.4 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EGD94549.1 - 0.0096 14.7 0.0 0.012 14.4 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Pkinase PF00069.25 EGD94550.1 - 3.8e-26 92.0 0.0 1.5e-25 90.0 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD94550.1 - 2.9e-11 43.2 0.0 3.1e-10 39.8 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase RRM_1 PF00076.22 EGD94551.1 - 2.7e-10 39.9 0.0 0.00017 21.3 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) G-patch PF01585.23 EGD94551.1 - 1e-09 38.1 3.6 2.3e-09 37.0 3.6 1.6 1 0 0 1 1 1 1 G-patch domain zf-RanBP PF00641.18 EGD94551.1 - 4.8e-09 35.4 1.1 7.5e-09 34.7 1.1 1.3 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others G-patch_2 PF12656.7 EGD94551.1 - 0.00024 21.1 2.9 0.00083 19.4 2.9 1.9 1 0 0 1 1 1 1 G-patch domain Rad50_zn_hook PF04423.14 EGD94551.1 - 0.037 13.9 0.2 0.11 12.4 0.2 1.7 1 0 0 1 1 1 0 Rad50 zinc hook motif TRAF_BIRC3_bd PF16673.5 EGD94552.1 - 0.013 15.3 1.5 0.019 14.7 1.5 1.4 1 0 0 1 1 1 0 TNF receptor-associated factor BIRC3 binding domain Nexin_C PF08628.12 EGD94553.1 - 0.25 11.9 2.4 0.51 10.9 2.5 1.8 1 1 0 1 1 1 0 Sorting nexin C terminal SLAC1 PF03595.17 EGD94554.1 - 1.1e-97 327.2 56.7 1.2e-97 327.0 56.7 1.0 1 0 0 1 1 1 1 Voltage-dependent anion channel Caerin_1 PF07440.12 EGD94554.1 - 0.96 9.6 3.0 21 5.3 1.1 2.5 2 0 0 2 2 2 0 Caerin 1 protein T4SS_CagC PF16943.5 EGD94554.1 - 3.7 7.8 6.2 1.3 9.2 0.3 2.5 2 0 0 2 2 2 0 Cag pathogenicity island, type IV secretory system MoaE PF02391.17 EGD94555.1 - 4.5e-36 123.6 0.1 5.5e-36 123.3 0.1 1.1 1 0 0 1 1 1 1 MoaE protein Ntox25 PF15530.6 EGD94555.1 - 0.2 11.8 0.0 0.3 11.3 0.0 1.2 1 0 0 1 1 1 0 Bacterial toxin 25 SCO1-SenC PF02630.14 EGD94556.1 - 7.2e-43 145.7 0.0 1.1e-42 145.1 0.0 1.3 1 0 0 1 1 1 1 SCO1/SenC Thioredoxin_8 PF13905.6 EGD94556.1 - 0.11 12.9 0.0 0.24 11.7 0.0 1.7 1 1 0 1 1 1 0 Thioredoxin-like DUF572 PF04502.13 EGD94557.1 - 3.8 7.1 41.3 0.25 10.9 1.1 3.3 3 0 0 3 3 3 0 Family of unknown function (DUF572) MFS_1 PF07690.16 EGD94558.1 - 4.9e-29 101.4 24.2 4.9e-29 101.4 24.2 1.9 1 1 0 1 1 1 1 Major Facilitator Superfamily MFS_4 PF06779.14 EGD94558.1 - 2.4e-08 33.7 0.5 2.4e-08 33.7 0.5 3.1 3 1 1 4 4 4 1 Uncharacterised MFS-type transporter YbfB HNH_2 PF13391.6 EGD94559.1 - 1.8e-10 40.8 0.1 3.9e-10 39.7 0.1 1.6 1 0 0 1 1 1 1 HNH endonuclease ABC_tran PF00005.27 EGD94562.1 - 1.9e-52 177.4 0.0 4.7e-32 111.4 0.0 2.7 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 EGD94562.1 - 1.7e-25 90.2 8.5 1.7e-25 90.2 8.5 3.0 2 1 1 3 3 3 1 ABC transporter transmembrane region SMC_N PF02463.19 EGD94562.1 - 7.3e-08 32.1 3.1 0.015 14.7 0.0 4.3 4 0 0 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EGD94562.1 - 4.7e-07 29.5 0.8 0.018 14.8 0.1 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_22 PF13401.6 EGD94562.1 - 5.8e-07 29.9 0.3 0.038 14.3 0.0 3.4 3 1 0 3 3 2 2 AAA domain DUF87 PF01935.17 EGD94562.1 - 5.4e-06 26.7 7.5 0.00068 19.8 0.3 3.2 3 0 0 3 3 3 2 Helicase HerA, central domain RsgA_GTPase PF03193.16 EGD94562.1 - 1.1e-05 25.4 1.0 0.075 12.9 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase AAA_16 PF13191.6 EGD94562.1 - 1.1e-05 25.9 0.1 0.13 12.7 0.0 2.9 2 0 0 2 2 2 2 AAA ATPase domain AAA_21 PF13304.6 EGD94562.1 - 7.4e-05 22.7 0.0 0.34 10.7 0.1 3.2 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system MMR_HSR1 PF01926.23 EGD94562.1 - 9.7e-05 22.4 0.2 0.28 11.3 0.0 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_23 PF13476.6 EGD94562.1 - 0.00025 21.6 0.3 0.53 10.8 0.0 2.5 2 0 0 2 2 2 2 AAA domain Dynamin_N PF00350.23 EGD94562.1 - 0.00042 20.4 0.7 0.1 12.6 0.1 2.5 2 0 0 2 2 2 1 Dynamin family AAA_7 PF12775.7 EGD94562.1 - 0.00045 19.8 0.2 0.16 11.5 0.1 2.4 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_25 PF13481.6 EGD94562.1 - 0.00069 19.2 0.1 0.72 9.4 0.0 2.9 2 0 0 2 2 2 1 AAA domain FtsK_SpoIIIE PF01580.18 EGD94562.1 - 0.00083 18.8 0.8 0.7 9.2 0.1 2.6 3 0 0 3 3 2 2 FtsK/SpoIIIE family Zeta_toxin PF06414.12 EGD94562.1 - 0.0015 17.9 0.1 0.81 8.9 0.0 2.6 2 0 0 2 2 2 1 Zeta toxin T2SSE PF00437.20 EGD94562.1 - 0.0022 17.1 1.3 1.2 8.1 0.1 2.4 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_24 PF13479.6 EGD94562.1 - 0.0044 16.8 0.4 1.3 8.7 0.0 3.3 3 0 0 3 3 3 1 AAA domain AAA PF00004.29 EGD94562.1 - 0.006 17.0 1.9 34 4.9 0.1 4.3 3 1 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 EGD94562.1 - 0.008 16.3 0.2 5.2 7.2 0.2 2.6 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 EGD94562.1 - 0.0082 16.7 0.1 7 7.2 0.0 2.6 2 0 0 2 2 2 0 AAA domain Viral_helicase1 PF01443.18 EGD94562.1 - 0.02 14.6 0.6 3.5 7.3 0.0 3.2 3 0 0 3 3 3 0 Viral (Superfamily 1) RNA helicase DUF815 PF05673.13 EGD94562.1 - 0.021 14.0 0.1 1.6 7.8 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF815) NB-ARC PF00931.22 EGD94562.1 - 0.025 13.7 0.5 2.1 7.4 0.0 2.9 2 1 0 2 2 2 0 NB-ARC domain Mg_chelatase PF01078.21 EGD94562.1 - 0.028 13.8 0.2 1.6 8.1 0.0 2.8 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 EGD94562.1 - 0.043 14.2 0.1 8.4 6.8 0.0 2.6 2 0 0 2 2 2 0 RNA helicase cobW PF02492.19 EGD94562.1 - 0.043 13.4 1.5 1.6 8.3 0.3 2.5 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_15 PF13175.6 EGD94562.1 - 0.05 13.3 0.2 3.2 7.4 0.0 2.5 2 1 0 2 2 2 0 AAA ATPase domain SbcCD_C PF13558.6 EGD94562.1 - 0.083 13.1 0.1 16 5.8 0.0 2.9 2 0 0 2 2 2 0 Putative exonuclease SbcCD, C subunit SNARE PF05739.19 EGD94562.1 - 0.14 12.1 0.0 0.56 10.2 0.0 2.1 1 0 0 1 1 1 0 SNARE domain TrwB_AAD_bind PF10412.9 EGD94562.1 - 0.15 10.9 1.3 9.4 5.0 0.1 2.3 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain dNK PF01712.19 EGD94562.1 - 0.2 11.5 0.3 7 6.4 0.0 2.3 2 0 0 2 2 2 0 Deoxynucleoside kinase TsaE PF02367.17 EGD94562.1 - 0.21 11.6 0.3 23 5.0 0.1 2.4 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE DUF3040 PF11239.8 EGD94562.1 - 2.5 8.4 9.6 6.4 7.1 0.0 5.0 5 0 0 5 5 4 0 Protein of unknown function (DUF3040) DUF3459 PF11941.8 EGD94563.1 - 0.047 14.0 0.0 0.075 13.4 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3459) Neocarzinostat PF00960.18 EGD94563.1 - 0.049 13.6 0.7 0.13 12.2 0.2 1.8 1 1 0 2 2 2 0 Neocarzinostatin family AMP-binding PF00501.28 EGD94564.1 - 1e-142 475.7 0.0 5.4e-70 236.1 0.0 5.7 5 2 2 7 7 7 4 AMP-binding enzyme Condensation PF00668.20 EGD94564.1 - 4.5e-93 312.4 0.0 6.7e-30 104.1 0.0 5.0 5 1 0 5 5 5 4 Condensation domain PP-binding PF00550.25 EGD94564.1 - 4.5e-26 91.0 0.2 1.3e-13 51.1 0.0 2.7 2 0 0 2 2 2 2 Phosphopantetheine attachment site AMP-binding_C PF13193.6 EGD94564.1 - 0.00086 20.2 0.0 0.019 15.9 0.0 2.5 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain Amidase PF01425.21 EGD94565.1 - 1.4e-36 126.4 0.2 2.7e-36 125.5 0.2 1.4 1 0 0 1 1 1 1 Amidase Amino_oxidase PF01593.24 EGD94566.1 - 3.7e-33 115.5 0.0 4.6e-33 115.2 0.0 1.1 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EGD94566.1 - 1.2e-05 25.4 0.0 2.8e-05 24.2 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 EGD94566.1 - 0.024 13.9 0.3 0.046 13.0 0.3 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase ARL2_Bind_BART PF11527.8 EGD94566.1 - 0.14 12.3 0.2 0.31 11.2 0.2 1.5 1 0 0 1 1 1 0 The ARF-like 2 binding protein BART Abhydrolase_4 PF08386.10 EGD94567.1 - 2.3e-19 69.4 0.0 6.2e-19 68.0 0.0 1.7 2 0 0 2 2 2 1 TAP-like protein Abhydrolase_1 PF00561.20 EGD94567.1 - 1.5e-12 47.7 0.0 2.2e-11 43.9 0.0 2.3 2 0 0 2 2 2 1 alpha/beta hydrolase fold Beta-lactamase PF00144.24 EGD94568.1 - 2.2e-45 155.3 0.0 3e-45 154.9 0.0 1.1 1 0 0 1 1 1 1 Beta-lactamase DUF3471 PF11954.8 EGD94568.1 - 1.7e-10 41.3 0.1 3.4e-10 40.3 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3471) Ank_4 PF13637.6 EGD94569.1 - 2.8e-43 145.7 1.6 2.9e-09 37.3 0.0 5.6 2 1 5 7 7 6 6 Ankyrin repeats (many copies) Ank_2 PF12796.7 EGD94569.1 - 1.4e-38 131.4 0.0 6.3e-13 49.1 0.0 4.1 2 1 2 4 4 4 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EGD94569.1 - 4.3e-32 106.5 0.0 5.4e-06 26.4 0.0 7.0 6 0 0 6 6 6 6 Ankyrin repeat Ank PF00023.30 EGD94569.1 - 5.9e-32 108.7 0.0 3.5e-07 30.4 0.0 6.9 6 0 0 6 6 6 5 Ankyrin repeat Ank_5 PF13857.6 EGD94569.1 - 1.2e-29 102.0 0.5 1.5e-11 44.3 0.1 6.1 3 1 5 8 8 6 5 Ankyrin repeats (many copies) NACHT PF05729.12 EGD94569.1 - 5.4e-12 45.9 0.0 1.3e-11 44.7 0.0 1.7 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 EGD94569.1 - 5e-05 23.7 0.0 0.0002 21.8 0.0 2.0 1 0 0 1 1 1 1 AAA ATPase domain NB-ARC PF00931.22 EGD94569.1 - 0.0022 17.2 0.0 0.0054 15.9 0.0 1.6 1 0 0 1 1 1 1 NB-ARC domain AAA_33 PF13671.6 EGD94569.1 - 0.011 15.9 0.0 0.027 14.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 EGD94569.1 - 0.017 15.4 0.0 0.057 13.7 0.0 1.9 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EGD94569.1 - 0.019 15.3 0.0 0.052 13.9 0.0 1.7 1 0 0 1 1 1 0 RNA helicase AAA_19 PF13245.6 EGD94569.1 - 0.026 14.9 0.0 1.5 9.2 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA PF00004.29 EGD94569.1 - 0.033 14.6 0.0 0.096 13.1 0.0 1.8 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.12 EGD94569.1 - 0.088 12.1 0.3 0.44 9.8 0.0 2.1 2 0 0 2 2 2 0 Zeta toxin DUF2075 PF09848.9 EGD94569.1 - 0.1 11.8 0.0 0.24 10.6 0.0 1.6 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Ank_2 PF12796.7 EGD94571.1 - 2.5e-73 242.7 0.9 3.1e-17 62.9 0.5 6.4 3 3 3 6 6 6 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EGD94571.1 - 8.2e-64 211.2 4.7 3.5e-12 46.6 0.0 9.1 6 2 4 10 10 10 9 Ankyrin repeats (many copies) Ank_3 PF13606.6 EGD94571.1 - 3.7e-55 177.4 4.3 0.00073 19.8 0.0 13.6 13 0 0 13 13 13 11 Ankyrin repeat Ank_5 PF13857.6 EGD94571.1 - 3e-50 167.6 4.9 1.5e-07 31.5 0.1 12.0 2 1 11 13 13 13 11 Ankyrin repeats (many copies) Ank PF00023.30 EGD94571.1 - 1.1e-48 161.6 10.6 0.00024 21.4 0.0 13.2 13 0 0 13 13 13 10 Ankyrin repeat HbrB PF08539.11 EGD94572.1 - 5.2e-50 169.7 0.7 1.4e-49 168.4 0.0 2.2 2 0 0 2 2 2 1 HbrB-like SUIM_assoc PF16619.5 EGD94572.1 - 3.3 7.8 12.5 1.5 9.0 5.3 3.3 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 UPF0239 PF06783.11 EGD94572.1 - 5.1 7.3 6.3 6.1 7.1 0.0 3.8 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0239) Trypsin_2 PF13365.6 EGD94575.1 - 0.0013 19.7 0.0 0.0045 17.9 0.0 1.8 1 1 0 1 1 1 1 Trypsin-like peptidase domain Peptidase_S64 PF08192.11 EGD94575.1 - 0.0046 15.5 0.8 0.062 11.8 0.8 2.1 1 1 0 1 1 1 1 Peptidase family S64 Peptidase_S32 PF05579.13 EGD94575.1 - 0.0082 15.4 0.0 0.018 14.2 0.0 1.5 1 0 0 1 1 1 1 Equine arteritis virus serine endopeptidase S32 Myb_DNA-bind_3 PF12776.7 EGD94576.1 - 0.00051 21.0 0.3 0.75 10.8 0.0 2.3 1 1 1 2 2 2 2 Myb/SANT-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EGD94576.1 - 0.00063 19.9 0.3 0.53 10.6 0.0 2.5 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_5 PF13873.6 EGD94576.1 - 0.026 14.6 1.7 1.2 9.3 0.1 2.5 2 0 0 2 2 2 0 Myb/SANT-like DNA-binding domain Myb_DNA-bind_4 PF13837.6 EGD94576.1 - 0.058 13.8 2.4 0.17 12.3 0.2 2.3 1 1 1 2 2 2 0 Myb/SANT-like DNA-binding domain AAA PF00004.29 EGD94577.1 - 6.9e-17 62.1 0.1 5.3e-16 59.2 0.0 2.5 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 EGD94577.1 - 0.00026 21.0 0.0 0.0008 19.4 0.0 1.8 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EGD94577.1 - 0.0012 19.1 0.5 0.014 15.7 0.1 2.6 1 1 1 2 2 2 1 AAA domain AAA_16 PF13191.6 EGD94577.1 - 0.0014 19.0 0.0 0.0086 16.5 0.0 2.2 1 1 0 1 1 1 1 AAA ATPase domain AAA_30 PF13604.6 EGD94577.1 - 0.0059 16.3 0.5 0.029 14.1 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 EGD94577.1 - 0.022 15.1 0.0 0.085 13.2 0.0 2.1 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 EGD94577.1 - 0.085 13.0 0.1 0.085 13.0 0.1 2.7 3 1 0 3 3 3 0 AAA domain Ldh_1_C PF02866.18 EGD94579.1 - 3.2e-48 163.8 0.0 7.1e-48 162.7 0.0 1.6 2 0 0 2 2 2 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.23 EGD94579.1 - 3e-42 144.1 0.0 4.4e-42 143.5 0.0 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain 3Beta_HSD PF01073.19 EGD94579.1 - 0.00022 20.3 0.0 0.00032 19.8 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Glyco_hydro_4 PF02056.16 EGD94579.1 - 0.029 13.9 0.0 0.66 9.5 0.2 2.3 1 1 1 2 2 2 0 Family 4 glycosyl hydrolase V-SNARE_C PF12352.8 EGD94582.1 - 7.9e-16 58.1 1.0 7.9e-16 58.1 1.0 1.9 2 0 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.13 EGD94582.1 - 9.3e-06 25.5 0.0 1.8e-05 24.5 0.0 1.4 1 0 0 1 1 1 1 Sec20 BAR_2 PF10455.9 EGD94582.1 - 0.0045 16.2 0.1 0.0059 15.8 0.1 1.2 1 0 0 1 1 1 1 Bin/amphiphysin/Rvs domain for vesicular trafficking HTH_DeoR PF08220.12 EGD94582.1 - 0.02 14.6 0.1 4 7.3 0.0 2.4 2 0 0 2 2 2 0 DeoR-like helix-turn-helix domain Sigma70_r4 PF04545.16 EGD94582.1 - 0.021 14.3 0.1 0.048 13.2 0.1 1.6 1 0 0 1 1 1 0 Sigma-70, region 4 Pox_EPC_I2-L1 PF12575.8 EGD94582.1 - 0.033 14.4 0.1 0.85 9.9 0.0 2.2 2 0 0 2 2 2 0 Poxvirus entry protein complex L1 and I2 E2F_TDP PF02319.20 EGD94582.1 - 0.088 12.9 0.0 0.18 11.9 0.0 1.5 1 0 0 1 1 1 0 E2F/DP family winged-helix DNA-binding domain DUF745 PF05335.13 EGD94582.1 - 0.3 10.8 2.5 1.5 8.5 0.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF745) TPR_MLP1_2 PF07926.12 EGD94582.1 - 0.72 9.9 3.8 1.3 9.1 1.2 2.2 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein HNH_2 PF13391.6 EGD94583.1 - 2.6e-08 33.9 0.0 6.7e-08 32.6 0.0 1.7 1 0 0 1 1 1 1 HNH endonuclease DUF3246 PF11596.8 EGD94583.1 - 0.19 11.2 2.7 0.31 10.4 2.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3246) Phage_T4_gp19 PF06841.12 EGD94584.1 - 0.088 12.7 0.0 0.13 12.1 0.0 1.2 1 0 0 1 1 1 0 T4-like virus tail tube protein gp19 NDC10_II PF16787.5 EGD94585.1 - 0.024 13.7 0.1 0.037 13.1 0.1 1.2 1 0 0 1 1 1 0 Centromere DNA-binding protein complex CBF3 subunit, domain 2 Glyco_hydro_18 PF00704.28 EGD94586.1 - 1.7e-33 116.7 1.3 2.7e-33 116.0 1.3 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 LysM PF01476.20 EGD94586.1 - 1.8e-08 34.3 0.0 4.6e-06 26.6 0.1 2.5 2 0 0 2 2 2 2 LysM domain Chitin_bind_1 PF00187.19 EGD94586.1 - 4.4e-05 23.9 8.8 4.4e-05 23.9 8.8 3.5 5 0 0 5 5 5 1 Chitin recognition protein HNH_2 PF13391.6 EGD94587.1 - 5.6e-13 48.8 0.0 2e-11 43.9 0.0 2.4 1 1 0 1 1 1 1 HNH endonuclease MFS_1 PF07690.16 EGD94588.1 - 3.8e-30 105.0 51.4 1.1e-18 67.3 24.1 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EGD94588.1 - 1.4e-09 37.3 22.7 9.2e-05 21.5 8.3 2.6 1 1 1 2 2 2 2 Sugar (and other) transporter F-box-like PF12937.7 EGD94589.1 - 1.3e-06 28.2 0.1 2.9e-06 27.0 0.1 1.6 1 0 0 1 1 1 1 F-box-like F-box_4 PF15966.5 EGD94589.1 - 0.007 16.2 0.3 0.022 14.6 0.0 1.9 2 0 0 2 2 2 1 F-box F-box PF00646.33 EGD94589.1 - 0.09 12.7 0.1 0.22 11.4 0.1 1.7 1 0 0 1 1 1 0 F-box domain UBM PF14377.6 EGD94589.1 - 0.13 11.8 0.3 0.35 10.4 0.1 1.9 2 0 0 2 2 2 0 Ubiquitin binding region His_Phos_1 PF00300.22 EGD94591.1 - 8.2e-20 71.3 0.0 2.1e-19 70.0 0.0 1.6 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) LSM PF01423.22 EGD94592.1 - 5.5e-18 64.4 0.0 7.1e-18 64.1 0.0 1.2 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EGD94592.1 - 0.0047 17.1 0.0 0.0059 16.7 0.0 1.3 1 1 0 1 1 1 1 Ataxin 2 SM domain DSPc PF00782.20 EGD94593.1 - 4.2e-10 39.5 0.1 7e-10 38.8 0.1 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EGD94593.1 - 5.8e-06 26.0 0.0 8.9e-06 25.4 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 EGD94593.1 - 0.0051 16.9 0.0 0.0096 16.0 0.0 1.3 1 0 0 1 1 1 1 Inositol hexakisphosphate AChE_tetra PF08674.10 EGD94593.1 - 0.014 15.1 0.5 0.044 13.5 0.5 1.9 1 0 0 1 1 1 0 Acetylcholinesterase tetramerisation domain Y_phosphatase3 PF13350.6 EGD94593.1 - 0.023 14.7 0.0 0.038 13.9 0.0 1.2 1 0 0 1 1 1 0 Tyrosine phosphatase family CDKN3 PF05706.12 EGD94593.1 - 0.042 13.5 0.0 0.064 12.9 0.0 1.2 1 0 0 1 1 1 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) PPR_2 PF13041.6 EGD94594.1 - 1.2e-15 57.4 0.0 0.04 14.1 0.1 7.3 5 2 3 8 8 8 5 PPR repeat family PPR PF01535.20 EGD94594.1 - 7.4e-12 44.7 5.9 0.054 13.8 0.0 7.6 9 0 0 9 9 9 2 PPR repeat PPR_3 PF13812.6 EGD94594.1 - 2.4e-11 43.5 0.3 0.32 11.1 0.0 6.7 5 2 2 7 7 7 4 Pentatricopeptide repeat domain PPR_long PF17177.4 EGD94594.1 - 3.5e-10 39.6 0.0 0.0053 16.2 0.1 3.7 1 1 2 3 3 3 3 Pentacotripeptide-repeat region of PRORP Dak1_2 PF13684.6 EGD94594.1 - 0.048 12.7 0.0 0.088 11.9 0.0 1.3 1 0 0 1 1 1 0 Dihydroxyacetone kinase family Frtz PF11768.8 EGD94594.1 - 0.064 11.6 0.0 0.1 10.9 0.0 1.2 1 0 0 1 1 1 0 WD repeat-containing and planar cell polarity effector protein Fritz TPR_7 PF13176.6 EGD94594.1 - 0.067 13.3 0.1 91 3.4 0.0 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat PLA2_B PF01735.18 EGD94595.1 - 7.6e-28 97.2 0.0 1.1e-27 96.7 0.0 1.1 1 0 0 1 1 1 1 Lysophospholipase catalytic domain Exo70 PF03081.15 EGD94596.1 - 1.2e-87 294.4 0.0 1.9e-87 293.8 0.0 1.3 1 0 0 1 1 1 1 Exo70 exocyst complex subunit Pax2_C PF12403.8 EGD94596.1 - 0.14 12.3 0.2 0.83 9.7 0.0 2.1 2 0 0 2 2 2 0 Paired-box protein 2 C terminal Laminin_II PF06009.12 EGD94596.1 - 0.37 10.8 2.2 3.6 7.6 0.3 2.7 2 0 0 2 2 2 0 Laminin Domain II Sec34 PF04136.15 EGD94596.1 - 0.4 10.5 2.3 4.6 7.1 0.0 3.5 3 2 1 4 4 4 0 Sec34-like family Ank_2 PF12796.7 EGD94597.1 - 2e-27 95.6 0.6 1.1e-10 41.9 0.1 4.7 2 1 2 4 4 4 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EGD94597.1 - 1.9e-22 79.3 2.4 6.2e-10 39.4 0.2 4.7 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EGD94597.1 - 3.9e-18 63.7 2.1 0.0048 17.3 0.0 7.0 7 0 0 7 7 7 4 Ankyrin repeat Ank PF00023.30 EGD94597.1 - 2.5e-17 62.4 3.9 0.0035 17.7 0.1 5.9 5 0 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.6 EGD94597.1 - 1.8e-16 60.0 1.3 9.5e-06 25.8 0.0 4.6 1 1 4 5 5 5 4 Ankyrin repeats (many copies) NACHT PF05729.12 EGD94597.1 - 1.7e-05 24.8 0.1 5.7e-05 23.1 0.0 1.9 2 0 0 2 2 2 1 NACHT domain AAA_22 PF13401.6 EGD94597.1 - 3.4e-05 24.1 0.0 0.00018 21.8 0.0 2.2 2 0 0 2 2 2 1 AAA domain Helo_like_N PF17111.5 EGD94597.1 - 0.0095 15.3 1.0 0.077 12.4 1.0 2.2 1 1 0 1 1 1 1 Fungal N-terminal domain of STAND proteins BtpA PF03437.15 EGD94597.1 - 0.18 11.2 0.0 1.3 8.4 0.0 2.0 2 0 0 2 2 2 0 BtpA family BCDHK_Adom3 PF10436.9 EGD94600.1 - 3.6e-30 104.9 0.0 4.3e-30 104.7 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase STE2 PF02116.15 EGD94601.1 - 9.2e-87 290.9 24.4 1e-86 290.8 24.4 1.0 1 0 0 1 1 1 1 Fungal pheromone mating factor STE2 GPCR TPPK_C PF12555.8 EGD94601.1 - 4.6 7.4 8.0 6.8 6.8 2.0 2.7 2 0 0 2 2 2 0 Thiamine pyrophosphokinase C terminal Metallophos PF00149.28 EGD94602.1 - 9.7e-09 36.0 0.2 1.4e-08 35.5 0.2 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Kdo PF06293.14 EGD94604.1 - 3.1e-08 33.2 0.0 0.0035 16.7 0.0 3.1 3 0 0 3 3 3 3 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EGD94604.1 - 3.4e-08 33.7 0.0 0.006 16.5 0.0 2.9 2 1 1 3 3 3 2 Phosphotransferase enzyme family Pkinase PF00069.25 EGD94604.1 - 8e-07 28.7 0.0 1.3e-06 28.0 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 EGD94604.1 - 0.011 14.5 0.0 0.015 14.1 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase Pkinase_Tyr PF07714.17 EGD94604.1 - 0.015 14.6 0.0 0.034 13.4 0.0 1.6 2 0 0 2 2 2 0 Protein tyrosine kinase RIO1 PF01163.22 EGD94604.1 - 0.022 14.3 0.0 1.1 8.8 0.0 2.8 3 0 0 3 3 3 0 RIO1 family Choline_kinase PF01633.20 EGD94604.1 - 0.09 12.3 0.0 0.13 11.8 0.0 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase Aldo_ket_red PF00248.21 EGD94605.1 - 1.7e-13 50.4 0.0 2.5e-13 49.9 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family Clat_adaptor_s PF01217.20 EGD94606.1 - 8.1e-53 178.2 1.9 9.7e-53 177.9 1.9 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain PulA_N1 PF17999.1 EGD94606.1 - 0.056 14.2 0.2 0.1 13.3 0.2 1.5 1 1 0 1 1 1 0 Pullulanase N1-terminal domain Maf1 PF09174.10 EGD94607.1 - 1.1e-58 198.3 0.1 1.6e-58 197.7 0.1 1.2 1 0 0 1 1 1 1 Maf1 regulator Filament PF00038.21 EGD94608.1 - 0.00048 19.8 20.2 0.00048 19.8 20.2 4.1 1 1 2 3 3 3 1 Intermediate filament protein Tropomyosin_1 PF12718.7 EGD94608.1 - 0.001 19.2 29.6 0.001 19.2 29.6 5.3 5 1 1 6 6 6 2 Tropomyosin like TSC22 PF01166.18 EGD94608.1 - 0.11 12.9 0.1 0.11 12.9 0.1 5.7 6 2 2 8 8 8 0 TSC-22/dip/bun family NPV_P10 PF05531.12 EGD94608.1 - 2.8 8.5 18.2 4.1 7.9 4.5 4.5 1 1 2 3 3 3 0 Nucleopolyhedrovirus P10 protein MscS_porin PF12795.7 EGD94608.1 - 6.3 6.3 58.6 0.025 14.1 41.2 3.7 2 1 1 3 3 3 0 Mechanosensitive ion channel porin domain N2227 PF07942.12 EGD94609.1 - 3e-60 203.7 0.0 3.9e-60 203.4 0.0 1.1 1 0 0 1 1 1 1 N2227-like protein Methyltransf_23 PF13489.6 EGD94609.1 - 0.0049 16.7 0.0 0.0096 15.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Abhydrolase_6 PF12697.7 EGD94611.1 - 1.2e-17 65.3 0.0 1.6e-17 64.9 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EGD94611.1 - 2.7e-05 23.5 0.1 0.00023 20.5 0.1 2.3 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Chlorophyllase PF07224.11 EGD94611.1 - 0.0046 16.0 0.0 0.059 12.4 0.0 2.0 1 1 1 2 2 2 1 Chlorophyllase Chlorophyllase2 PF12740.7 EGD94611.1 - 0.13 11.2 0.0 0.17 10.8 0.0 1.3 1 0 0 1 1 1 0 Chlorophyllase enzyme COPIIcoated_ERV PF07970.12 EGD94612.1 - 1.2e-32 113.5 0.0 2.5e-32 112.5 0.0 1.5 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 EGD94612.1 - 3.5e-23 81.8 0.0 5.9e-23 81.0 0.0 1.4 1 0 0 1 1 1 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Pkinase PF00069.25 EGD94613.1 - 4.2e-30 105.0 0.2 6.5e-30 104.4 0.2 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD94613.1 - 1.2e-13 50.9 0.1 1.8e-13 50.4 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase ABC1 PF03109.16 EGD94613.1 - 0.16 12.1 0.1 0.31 11.2 0.1 1.4 1 0 0 1 1 1 0 ABC1 family Pex24p PF06398.11 EGD94614.1 - 1.8e-82 277.3 0.1 2.5e-82 276.8 0.1 1.2 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin DUF3292 PF11696.8 EGD94614.1 - 0.0016 16.9 0.0 0.0028 16.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3292) Nop16 PF09420.10 EGD94616.1 - 3.2e-63 213.6 8.8 3.6e-63 213.4 8.8 1.0 1 0 0 1 1 1 1 Ribosome biogenesis protein Nop16 DUF3283 PF11686.8 EGD94616.1 - 0.41 10.5 5.0 0.12 12.2 0.8 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3283) Zip PF02535.22 EGD94617.1 - 1.2e-54 185.7 12.7 7.7e-54 183.1 12.7 1.8 1 1 0 1 1 1 1 ZIP Zinc transporter DUF456 PF04306.13 EGD94617.1 - 5.5 7.3 18.4 39 4.5 13.0 3.1 2 1 0 2 2 2 0 Protein of unknown function (DUF456) Anp1 PF03452.14 EGD94618.1 - 1.4e-102 342.7 0.0 1.8e-102 342.3 0.0 1.1 1 0 0 1 1 1 1 Anp1 Glycos_transf_2 PF00535.26 EGD94618.1 - 0.013 15.3 0.0 0.024 14.5 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferase family 2 Mito_carr PF00153.27 EGD94619.1 - 7.6e-52 173.2 0.3 2.4e-18 65.9 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Ank_2 PF12796.7 EGD94621.1 - 1.7e-58 195.1 1.5 1.5e-10 41.5 0.0 7.1 2 2 4 7 7 7 6 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EGD94621.1 - 1.9e-46 155.5 10.8 5.8e-11 42.4 0.1 10.7 5 2 8 13 13 13 12 Ankyrin repeats (many copies) Ank_4 PF13637.6 EGD94621.1 - 2.2e-45 152.4 3.4 2.4e-07 31.2 0.0 11.1 5 3 6 11 11 11 10 Ankyrin repeats (many copies) Ank_3 PF13606.6 EGD94621.1 - 1.1e-40 133.0 5.6 0.0006 20.1 0.0 13.9 14 0 0 14 14 14 10 Ankyrin repeat Ank PF00023.30 EGD94621.1 - 3.5e-34 115.7 14.4 0.011 16.1 0.1 12.9 14 0 0 14 14 14 9 Ankyrin repeat Chorismate_bind PF00425.18 EGD94622.1 - 5.6e-86 288.3 0.0 8.8e-86 287.6 0.0 1.3 1 0 0 1 1 1 1 chorismate binding enzyme GATase PF00117.28 EGD94622.1 - 1.2e-36 126.3 0.0 1.8e-36 125.7 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Anth_synt_I_N PF04715.13 EGD94622.1 - 1.9e-09 37.9 0.0 4.6e-09 36.6 0.0 1.6 1 0 0 1 1 1 1 Anthranilate synthase component I, N terminal region Peptidase_C26 PF07722.13 EGD94622.1 - 9.7e-09 35.3 0.0 2.2e-08 34.1 0.0 1.6 1 0 0 1 1 1 1 Peptidase C26 MFS_1 PF07690.16 EGD94623.1 - 2e-36 125.7 26.8 3e-36 125.1 26.8 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_4 PF06779.14 EGD94623.1 - 4.7e-06 26.2 1.6 4.7e-06 26.2 1.6 2.2 2 0 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB DHDPS PF00701.22 EGD94625.1 - 2e-41 141.6 0.0 2.3e-41 141.4 0.0 1.0 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family DUF2014 PF09427.10 EGD94626.1 - 2.5e-102 341.7 0.2 3.4e-102 341.3 0.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF2014) HLH PF00010.26 EGD94626.1 - 1.5e-17 63.3 2.2 2.9e-17 62.4 2.2 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain ZapB PF06005.12 EGD94626.1 - 0.13 12.7 1.4 0.27 11.7 0.9 1.7 2 0 0 2 2 2 0 Cell division protein ZapB bZIP_1 PF00170.21 EGD94626.1 - 0.6 10.2 3.7 0.54 10.4 2.0 1.8 2 0 0 2 2 2 0 bZIP transcription factor E1-E2_ATPase PF00122.20 EGD94627.1 - 5.5e-40 136.8 14.3 1.6e-31 109.3 0.0 3.7 3 1 1 4 4 4 2 E1-E2 ATPase Cation_ATPase_C PF00689.21 EGD94627.1 - 1.1e-26 93.7 4.1 1.1e-26 93.7 4.1 2.4 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 EGD94627.1 - 3.7e-19 69.8 0.3 9.9e-16 58.7 0.1 2.5 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EGD94627.1 - 9.8e-17 60.4 0.1 9.2e-16 57.3 0.0 2.5 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Cation_ATPase PF13246.6 EGD94627.1 - 8.8e-12 45.0 0.0 1.7e-11 44.0 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 EGD94627.1 - 1.9e-05 24.6 1.5 1.9e-05 24.6 1.5 1.6 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase DUF2463 PF09591.10 EGD94627.1 - 0.0081 16.1 0.9 0.025 14.4 0.9 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF2463) RNase_PH PF01138.21 EGD94628.1 - 0.12 12.8 0.1 0.25 11.9 0.1 1.5 1 1 0 1 1 1 0 3' exoribonuclease family, domain 1 Pro-kuma_activ PF09286.11 EGD94630.1 - 2.1e-35 122.1 0.0 3.4e-35 121.4 0.0 1.3 1 0 0 1 1 1 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.22 EGD94630.1 - 1.8e-08 34.0 0.2 3.8e-08 33.0 0.2 1.6 1 1 0 1 1 1 1 Subtilase family NAD_kinase PF01513.21 EGD94631.1 - 8.4e-66 222.1 0.0 8.3e-65 218.9 0.0 2.1 1 1 0 1 1 1 1 ATP-NAD kinase DAO PF01266.24 EGD94632.1 - 1.9e-33 116.5 0.1 2.5e-30 106.3 0.1 2.0 1 1 0 1 1 1 1 FAD dependent oxidoreductase K_oxygenase PF13434.6 EGD94632.1 - 0.091 11.9 0.0 0.27 10.3 0.0 1.6 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) Thi4 PF01946.17 EGD94632.1 - 0.15 11.3 0.0 0.24 10.6 0.0 1.3 1 0 0 1 1 1 0 Thi4 family GAF_2 PF13185.6 EGD94633.1 - 1.2e-11 45.1 0.0 1.5e-11 44.8 0.0 1.2 1 0 0 1 1 1 1 GAF domain GAF PF01590.26 EGD94633.1 - 4.8e-06 27.2 0.0 5.2e-06 27.1 0.0 1.2 1 0 0 1 1 1 1 GAF domain DEAD PF00270.29 EGD94634.1 - 1.6e-35 122.5 0.6 6.2e-35 120.5 0.1 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EGD94634.1 - 6.8e-24 84.4 0.1 2.3e-23 82.6 0.1 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain AAA_30 PF13604.6 EGD94634.1 - 0.1 12.3 0.0 0.19 11.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain tRNA-synt_1b PF00579.25 EGD94634.1 - 0.14 11.5 0.0 0.25 10.6 0.0 1.3 1 0 0 1 1 1 0 tRNA synthetases class I (W and Y) SH3_9 PF14604.6 EGD94635.1 - 1.3e-24 85.8 0.9 3.5e-12 46.0 0.1 2.5 2 0 0 2 2 2 2 Variant SH3 domain FCH PF00611.23 EGD94635.1 - 4.2e-18 65.4 2.0 6.5e-18 64.8 0.2 2.3 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain C1_1 PF00130.22 EGD94635.1 - 1.1e-15 57.3 5.2 1.7e-15 56.6 5.2 1.3 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) SH3_1 PF00018.28 EGD94635.1 - 3.1e-15 55.5 0.2 1.5e-06 27.7 0.0 2.4 2 0 0 2 2 2 2 SH3 domain SH3_2 PF07653.17 EGD94635.1 - 4.8e-06 26.2 0.1 0.00086 18.9 0.0 2.4 2 0 0 2 2 2 2 Variant SH3 domain C1_2 PF03107.16 EGD94635.1 - 0.046 14.1 5.3 0.083 13.2 5.3 1.4 1 0 0 1 1 1 0 C1 domain SH3_3 PF08239.11 EGD94635.1 - 0.05 13.9 0.4 0.56 10.5 0.1 2.4 2 0 0 2 2 2 0 Bacterial SH3 domain FapA PF03961.13 EGD94635.1 - 1.9 7.0 7.3 0.54 8.8 1.1 2.4 2 0 0 2 2 2 0 Flagellar Assembly Protein A Glyco_hydro_72 PF03198.14 EGD94636.1 - 1.3e-137 458.3 3.4 1.5e-137 458.0 3.4 1.0 1 0 0 1 1 1 1 Glucanosyltransferase Cellulase PF00150.18 EGD94636.1 - 2.2e-07 30.6 0.4 8.7e-07 28.6 0.5 1.8 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Arf PF00025.21 EGD94637.1 - 9.5e-74 246.6 0.1 1.1e-73 246.4 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EGD94637.1 - 5.6e-14 52.4 0.0 7.6e-14 52.0 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 EGD94637.1 - 1.4e-11 44.1 0.0 1.8e-11 43.8 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 EGD94637.1 - 2.1e-10 40.4 0.0 2.5e-10 40.2 0.0 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 EGD94637.1 - 2.4e-10 40.1 0.3 3.3e-06 26.5 0.0 2.4 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.12 EGD94637.1 - 2.7e-08 33.5 0.0 3.5e-08 33.1 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EGD94637.1 - 2.2e-06 27.7 0.0 4e-06 26.9 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EGD94637.1 - 0.00029 20.4 0.0 0.025 14.1 0.0 2.1 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 EGD94637.1 - 0.006 16.1 0.5 0.026 14.1 0.5 2.0 1 1 0 1 1 1 1 Ferrous iron transport protein B AAA_18 PF13238.6 EGD94637.1 - 0.13 12.8 0.0 0.19 12.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain Actin PF00022.19 EGD94638.1 - 1.7e-27 96.1 0.0 2.6e-25 88.9 0.0 2.6 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 EGD94638.1 - 6.8e-06 25.1 0.0 0.0078 15.1 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein Actin_micro PF17003.5 EGD94638.1 - 6.7e-05 22.2 1.2 0.26 10.4 0.1 2.9 3 0 0 3 3 3 2 Putative actin-like family FtsA PF14450.6 EGD94638.1 - 0.07 13.6 0.0 0.18 12.3 0.0 1.7 2 0 0 2 2 2 0 Cell division protein FtsA Paf1 PF03985.13 EGD94639.1 - 1.1e-56 192.7 0.0 1.5e-56 192.3 0.0 1.2 1 0 0 1 1 1 1 Paf1 LON_substr_bdg PF02190.16 EGD94640.1 - 2.9e-23 82.8 0.0 4.6e-23 82.2 0.0 1.3 1 0 0 1 1 1 1 ATP-dependent protease La (LON) substrate-binding domain zf-C3HC4_2 PF13923.6 EGD94640.1 - 1.2e-12 47.4 21.9 5.6e-11 42.1 9.0 2.9 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EGD94640.1 - 1.3e-12 47.5 28.0 1.9e-08 34.1 3.4 3.8 3 0 0 3 3 3 2 RING-type zinc-finger zf-C3HC4_4 PF15227.6 EGD94640.1 - 2e-10 40.6 22.2 9.6e-06 25.7 7.4 3.2 2 2 0 2 2 2 2 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.6 EGD94640.1 - 5.5e-10 39.4 24.8 2.7e-08 34.0 8.5 2.9 2 0 0 2 2 2 2 Ring finger domain zf-RING_5 PF14634.6 EGD94640.1 - 8.5e-09 35.2 24.7 4.1e-07 29.9 7.7 2.8 2 0 0 2 2 2 2 zinc-RING finger domain zf-C3HC4 PF00097.25 EGD94640.1 - 1.4e-08 34.4 22.2 9.1e-07 28.7 9.1 3.0 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EGD94640.1 - 4.1e-07 29.8 7.2 4.1e-07 29.8 7.2 2.9 3 0 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) zf-RING_10 PF16685.5 EGD94640.1 - 5e-05 23.4 7.2 5e-05 23.4 7.2 2.6 2 0 0 2 2 2 1 zinc RING finger of MSL2 U-box PF04564.15 EGD94640.1 - 9.2e-05 22.5 1.7 0.012 15.8 0.2 3.1 3 0 0 3 3 3 1 U-box domain Prok-RING_4 PF14447.6 EGD94640.1 - 0.00012 21.8 20.3 0.00047 20.0 7.2 2.7 2 0 0 2 2 2 2 Prokaryotic RING finger family 4 zf-P11 PF03854.14 EGD94640.1 - 0.0011 18.6 6.8 0.0011 18.6 6.8 2.6 2 0 0 2 2 2 1 P-11 zinc finger zf-rbx1 PF12678.7 EGD94640.1 - 0.0026 18.0 3.2 0.0026 18.0 3.2 2.8 2 1 1 3 3 2 1 RING-H2 zinc finger domain zf-RING_4 PF14570.6 EGD94640.1 - 0.021 14.6 18.5 0.027 14.3 6.1 3.7 2 1 1 3 3 3 0 RING/Ubox like zinc-binding domain Baculo_IE-1 PF05290.11 EGD94640.1 - 0.89 9.5 8.3 1.2 9.1 1.2 2.5 2 0 0 2 2 2 0 Baculovirus immediate-early protein (IE-0) zf-Nse PF11789.8 EGD94640.1 - 4.1 7.3 13.2 0.069 13.0 4.7 2.3 2 0 0 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit RICTOR_N PF14664.6 EGD94641.1 - 7.1e-129 430.0 0.2 1.3e-128 429.2 0.2 1.5 1 0 0 1 1 1 1 Rapamycin-insensitive companion of mTOR, N-term RasGEF_N_2 PF14663.6 EGD94641.1 - 5.3e-38 129.7 0.1 2.9e-36 124.2 0.0 3.4 4 0 0 4 4 4 1 Rapamycin-insensitive companion of mTOR RasGEF_N domain RICTOR_M PF14666.6 EGD94641.1 - 6.1e-37 125.6 1.6 6.1e-34 115.9 0.2 4.7 3 1 1 4 4 4 1 Rapamycin-insensitive companion of mTOR, middle domain RICTOR_V PF14668.6 EGD94641.1 - 3.7e-29 100.8 1.7 1.5e-26 92.4 0.1 4.1 5 0 0 5 5 5 1 Rapamycin-insensitive companion of mTOR, domain 5 HR1 PF02185.16 EGD94641.1 - 2.9e-14 52.9 10.5 9e-14 51.3 10.5 1.9 1 0 0 1 1 1 1 Hr1 repeat DLP_helical PF18709.1 EGD94641.1 - 0.064 12.4 1.4 0.12 11.5 1.4 1.4 1 0 0 1 1 1 0 Dynamin-like helical domain Arm PF00514.23 EGD94641.1 - 1.5 9.0 5.3 51 4.1 0.1 4.1 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat Uricase PF01014.18 EGD94642.1 - 5.1e-74 246.7 0.7 4.4e-40 137.0 0.8 2.0 2 0 0 2 2 2 2 Uricase Mob_Pre PF01076.19 EGD94642.1 - 0.17 11.7 0.0 0.25 11.2 0.0 1.3 1 0 0 1 1 1 0 Plasmid recombination enzyme Ribosomal_L13 PF00572.18 EGD94643.1 - 3e-42 143.8 0.0 3.7e-42 143.5 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L13 PDZ_6 PF17820.1 EGD94643.1 - 0.065 13.1 0.0 0.31 10.9 0.0 2.0 2 0 0 2 2 2 0 PDZ domain Ribosomal_S9 PF00380.19 EGD94644.1 - 1.8e-31 109.2 0.2 2e-31 109.0 0.2 1.0 1 0 0 1 1 1 1 Ribosomal protein S9/S16 AAR2 PF05282.11 EGD94645.1 - 5.4e-90 302.3 0.4 1.7e-49 169.1 0.3 2.0 1 1 1 2 2 2 2 AAR2 protein DUF4604 PF15377.6 EGD94645.1 - 0.26 11.7 3.4 0.2 12.1 0.9 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4604) Ribosomal_S11 PF00411.19 EGD94646.1 - 2.2e-46 156.8 1.1 2.7e-46 156.5 1.1 1.1 1 0 0 1 1 1 1 Ribosomal protein S11 CBM_25 PF03423.13 EGD94646.1 - 0.12 12.7 0.0 0.23 11.7 0.0 1.5 1 0 0 1 1 1 0 Carbohydrate binding domain (family 25) PDH PF02153.17 EGD94647.1 - 1.3e-14 53.8 0.0 2e-14 53.2 0.0 1.3 1 0 0 1 1 1 1 Prephenate dehydrogenase F420_oxidored PF03807.17 EGD94647.1 - 2e-06 28.3 0.0 4.1e-06 27.3 0.0 1.5 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_2 PF03446.15 EGD94647.1 - 1.1e-05 25.7 0.0 2.4e-05 24.6 0.0 1.5 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase 2-Hacid_dh_C PF02826.19 EGD94647.1 - 0.0024 17.3 0.0 0.0042 16.5 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ApbA PF02558.16 EGD94647.1 - 0.0028 17.3 0.0 0.005 16.5 0.0 1.6 1 1 0 1 1 1 1 Ketopantoate reductase PanE/ApbA TrkA_N PF02254.18 EGD94647.1 - 0.021 15.1 0.0 0.046 14.0 0.0 1.6 1 0 0 1 1 1 0 TrkA-N domain 3HCDH_N PF02737.18 EGD94647.1 - 0.021 14.7 0.0 0.04 13.8 0.0 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Rossmann-like PF10727.9 EGD94647.1 - 0.085 12.7 0.0 0.16 11.8 0.0 1.4 1 0 0 1 1 1 0 Rossmann-like domain CDH-cyt PF16010.5 EGD94649.1 - 2e-26 92.8 0.1 3.3e-26 92.1 0.1 1.2 1 0 0 1 1 1 1 Cytochrome domain of cellobiose dehydrogenase Cytochrom_B561 PF03188.16 EGD94649.1 - 8.8e-09 35.6 12.8 8.8e-09 35.6 12.8 1.5 2 0 0 2 2 2 1 Eukaryotic cytochrome b561 UAA PF08449.11 EGD94649.1 - 0.02 14.1 1.9 0.035 13.3 1.6 1.6 1 1 0 1 1 1 0 UAA transporter family DOMON PF03351.17 EGD94649.1 - 0.04 14.1 0.1 0.072 13.3 0.1 1.4 1 0 0 1 1 1 0 DOMON domain DUF2427 PF10348.9 EGD94649.1 - 0.067 13.0 8.5 0.036 13.9 4.8 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF2427) DUF4083 PF13314.6 EGD94649.1 - 0.21 11.6 0.4 13 5.8 0.1 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4083) RRM_occluded PF16842.5 EGD94650.1 - 0.0023 17.7 0.3 0.0059 16.4 0.0 1.8 2 0 0 2 2 2 1 Occluded RNA-recognition motif Paf67 PF10255.9 EGD94651.1 - 5.7e-159 529.4 0.0 6.7e-159 529.2 0.0 1.0 1 0 0 1 1 1 1 RNA polymerase I-associated factor PAF67 TPR_2 PF07719.17 EGD94651.1 - 0.026 14.6 0.0 0.16 12.2 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TRAPPC-Trs85 PF12739.7 EGD94651.1 - 0.082 11.9 0.1 0.11 11.5 0.1 1.2 1 0 0 1 1 1 0 ER-Golgi trafficking TRAPP I complex 85 kDa subunit Fe-S_biosyn PF01521.20 EGD94652.1 - 2.3e-10 40.7 0.0 1.4e-08 34.9 0.0 2.3 1 1 0 1 1 1 1 Iron-sulphur cluster biosynthesis Hemerythrin PF01814.23 EGD94653.1 - 7.8e-11 42.7 0.3 1.4e-10 41.9 0.3 1.4 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain UvrD_C PF13361.6 EGD94653.1 - 0.064 12.6 0.1 0.071 12.5 0.1 1.1 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain Lactamase_B PF00753.27 EGD94654.1 - 1.1e-07 32.0 0.3 3.5e-07 30.4 0.1 1.9 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EGD94654.1 - 0.0013 18.3 0.0 0.0024 17.4 0.0 1.5 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Aminotran_5 PF00266.19 EGD94655.1 - 2.1e-07 30.2 0.0 6.5e-07 28.6 0.0 1.6 2 0 0 2 2 2 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 EGD94655.1 - 0.0013 18.1 0.0 0.0019 17.6 0.0 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family DUF1788 PF08747.11 EGD94655.1 - 0.14 12.1 0.0 0.25 11.3 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1788) DUF1077 PF06417.12 EGD94656.1 - 2.3e-50 169.5 2.5 2.9e-50 169.2 2.5 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1077) TMEM171 PF15471.6 EGD94656.1 - 0.12 11.3 5.5 0.22 10.5 5.5 1.4 1 0 0 1 1 1 0 Transmembrane protein family 171 Methyltransf_2 PF00891.18 EGD94657.1 - 2.8e-22 79.1 0.0 4.2e-22 78.5 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain Cnd3 PF12719.7 EGD94657.1 - 0.1 11.7 0.0 2 7.5 0.0 2.2 2 0 0 2 2 2 0 Nuclear condensing complex subunits, C-term domain Adaptin_N PF01602.20 EGD94660.1 - 4e-111 372.1 8.1 4.7e-111 371.9 8.1 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 EGD94660.1 - 4.9e-57 192.5 6.9 1.3e-55 187.8 1.1 2.8 3 0 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EGD94660.1 - 2.2e-13 50.4 6.3 2.3e-08 34.3 0.4 4.7 4 1 1 5 5 5 3 HEAT repeats HEAT PF02985.22 EGD94660.1 - 8.9e-10 38.0 4.8 0.019 15.2 0.0 5.8 7 0 0 7 7 7 3 HEAT repeat Atx10homo_assoc PF09759.9 EGD94660.1 - 0.00076 19.5 0.1 15 5.7 0.0 4.2 3 1 1 4 4 4 2 Spinocerebellar ataxia type 10 protein domain Arm PF00514.23 EGD94660.1 - 0.0013 18.7 5.4 3.6 7.8 0.0 5.3 5 0 0 5 5 5 1 Armadillo/beta-catenin-like repeat CLASP_N PF12348.8 EGD94660.1 - 0.0018 17.9 2.4 0.51 9.9 0.0 3.1 2 1 1 3 3 3 2 CLASP N terminal HEAT_EZ PF13513.6 EGD94660.1 - 0.0026 18.2 8.3 0.8 10.3 0.1 5.8 7 1 1 8 8 8 1 HEAT-like repeat Importin_rep_4 PF18808.1 EGD94660.1 - 0.099 12.9 0.1 11 6.3 0.0 3.5 3 0 0 3 3 3 0 Importin repeat RasGEF_N_2 PF14663.6 EGD94660.1 - 0.31 11.5 1.2 7.9 6.9 0.1 3.3 3 0 0 3 3 3 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain SH3_2 PF07653.17 EGD94661.1 - 4e-10 39.2 0.1 1.1e-09 37.8 0.0 1.8 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.28 EGD94661.1 - 5.7e-10 38.6 0.1 1.1e-09 37.7 0.1 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EGD94661.1 - 7e-09 35.4 0.1 1.9e-08 34.1 0.1 1.8 2 0 0 2 2 2 1 Variant SH3 domain DNA_pol_phi PF04931.13 EGD94661.1 - 4.9 5.1 6.8 8.2 4.4 6.8 1.2 1 0 0 1 1 1 0 DNA polymerase phi RPAP2_Rtr1 PF04181.13 EGD94662.1 - 2.7e-24 85.3 0.1 4e-24 84.7 0.1 1.3 1 0 0 1 1 1 1 Rtr1/RPAP2 family Ribosomal_S17e PF00833.18 EGD94663.1 - 8e-46 154.9 2.2 3.9e-45 152.7 2.2 1.8 1 1 0 1 1 1 1 Ribosomal S17 Mit_ribos_Mrp51 PF11709.8 EGD94664.1 - 5.9e-117 391.3 0.1 6.7e-117 391.1 0.1 1.0 1 0 0 1 1 1 1 Mitochondrial ribosomal protein subunit FAT PF02259.23 EGD94665.1 - 5.3e-131 436.9 0.3 5.3e-131 436.9 0.3 1.8 2 0 0 2 2 2 1 FAT domain PI3_PI4_kinase PF00454.27 EGD94665.1 - 1.6e-69 234.5 0.2 3.3e-69 233.5 0.2 1.6 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase DUF3385 PF11865.8 EGD94665.1 - 1.8e-68 229.5 6.8 6.8e-62 208.1 2.0 4.4 3 0 0 3 3 3 3 Domain of unknown function (DUF3385) FRB_dom PF08771.11 EGD94665.1 - 1.2e-40 137.9 2.7 7.4e-40 135.4 0.1 3.8 3 0 0 3 3 3 1 FKBP12-rapamycin binding domain HEAT_2 PF13646.6 EGD94665.1 - 5.1e-17 62.0 10.5 0.00019 21.8 0.0 9.4 8 2 1 9 9 9 3 HEAT repeats HEAT PF02985.22 EGD94665.1 - 8.6e-15 53.6 18.6 0.0023 18.1 0.1 12.4 13 0 0 13 13 12 1 HEAT repeat HEAT_EZ PF13513.6 EGD94665.1 - 9.7e-15 54.7 11.7 0.003 18.0 0.0 11.1 11 1 2 13 13 12 4 HEAT-like repeat FATC PF02260.20 EGD94665.1 - 1.3e-14 53.7 0.3 4.4e-14 52.0 0.3 2.0 1 0 0 1 1 1 1 FATC domain Cnd1 PF12717.7 EGD94665.1 - 6.2e-09 36.1 0.3 0.86 9.6 0.0 6.7 4 2 3 7 7 7 2 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 EGD94665.1 - 5.8e-08 31.7 6.2 0.016 13.8 0.1 5.3 3 2 1 5 5 5 2 Adaptin N terminal region UME PF08064.13 EGD94665.1 - 2.7e-05 24.0 7.2 7.3 6.6 0.0 6.9 6 2 0 6 6 6 1 UME (NUC010) domain MMS19_C PF12460.8 EGD94665.1 - 0.00033 19.9 11.0 0.029 13.5 0.1 4.8 4 1 0 4 4 4 2 RNAPII transcription regulator C-terminal CLASP_N PF12348.8 EGD94665.1 - 0.00043 19.9 0.2 20 4.7 0.0 5.2 5 1 0 5 5 5 0 CLASP N terminal Tti2 PF10521.9 EGD94665.1 - 0.0023 17.5 1.2 5.7 6.4 0.0 4.7 3 1 3 6 6 6 1 Tti2 family TPR_14 PF13428.6 EGD94665.1 - 0.017 15.9 5.1 9.4 7.4 0.0 5.0 3 1 1 4 4 3 0 Tetratricopeptide repeat IFRD PF05004.13 EGD94665.1 - 0.019 14.1 0.3 0.63 9.1 0.1 3.2 2 1 1 3 3 3 0 Interferon-related developmental regulator (IFRD) TPR_11 PF13414.6 EGD94665.1 - 0.07 12.8 0.6 2.3 8.0 0.0 3.1 2 0 0 2 2 2 0 TPR repeat Sec7_N PF12783.7 EGD94665.1 - 0.078 12.9 2.4 3.6 7.5 0.0 4.7 5 1 0 5 5 5 0 Guanine nucleotide exchange factor in Golgi transport N-terminal RTP1_C1 PF10363.9 EGD94665.1 - 0.087 13.0 0.5 40 4.5 0.0 5.2 5 0 0 5 5 5 0 Required for nuclear transport of RNA pol II C-terminus 1 Methyltransf_23 PF13489.6 EGD94667.1 - 3.8e-10 39.9 0.0 5.2e-10 39.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EGD94667.1 - 4.2e-08 33.8 0.0 8e-08 32.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EGD94667.1 - 9.2e-08 32.6 0.0 4.2e-07 30.5 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EGD94667.1 - 2.1e-07 31.6 0.0 3.5e-07 30.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EGD94667.1 - 8.2e-06 25.7 0.0 1e-05 25.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain KR PF08659.10 EGD94667.1 - 0.00012 22.0 0.0 0.00022 21.2 0.0 1.4 1 0 0 1 1 1 1 KR domain DREV PF05219.12 EGD94667.1 - 0.042 12.9 0.0 0.064 12.3 0.0 1.2 1 0 0 1 1 1 0 DREV methyltransferase MTS PF05175.14 EGD94667.1 - 0.062 12.8 0.0 0.1 12.2 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Pam16 PF03656.13 EGD94668.1 - 1.3e-35 122.1 0.2 1.6e-35 121.9 0.2 1.0 1 0 0 1 1 1 1 Pam16 Pex24p PF06398.11 EGD94669.1 - 2.5e-97 326.1 0.5 3.2e-97 325.8 0.5 1.1 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin DAHP_synth_1 PF00793.20 EGD94672.1 - 1.4e-101 339.0 0.0 1.6e-101 338.8 0.0 1.0 1 0 0 1 1 1 1 DAHP synthetase I family DUF2458 PF10454.9 EGD94673.1 - 1.6e-66 223.2 1.8 2.1e-66 222.8 1.8 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2458) Ribosomal_L50 PF10501.9 EGD94675.1 - 7.5e-17 61.5 0.0 1.5e-16 60.5 0.0 1.5 1 0 0 1 1 1 1 Ribosomal subunit 39S SAP PF02037.27 EGD94675.1 - 0.14 11.9 0.0 0.29 10.9 0.0 1.5 1 0 0 1 1 1 0 SAP domain Rtf2 PF04641.12 EGD94676.1 - 1.3e-33 116.5 0.0 1.6e-33 116.2 0.0 1.1 1 0 0 1 1 1 1 Rtf2 RING-finger zf-Nse PF11789.8 EGD94676.1 - 2.7e-05 23.9 0.0 7.3e-05 22.5 0.0 1.7 1 1 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-NOSIP PF15906.5 EGD94676.1 - 0.00048 20.2 0.0 0.00091 19.3 0.0 1.3 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein ApoO PF09769.9 EGD94676.1 - 0.028 14.4 0.0 0.087 12.8 0.0 1.8 3 0 0 3 3 3 0 Apolipoprotein O PRKCSH-like PF12999.7 EGD94677.1 - 3.2e-45 154.0 10.5 2.3e-41 141.5 10.5 2.6 1 1 0 1 1 1 1 Glucosidase II beta subunit-like PRKCSH_1 PF13015.6 EGD94677.1 - 1.3e-27 96.4 0.5 3.4e-27 95.0 0.5 1.7 1 0 0 1 1 1 1 Glucosidase II beta subunit-like protein PRKCSH PF07915.13 EGD94677.1 - 3e-09 37.8 0.9 3e-09 37.8 0.9 2.1 2 0 0 2 2 2 1 Glucosidase II beta subunit-like protein HMG_box PF00505.19 EGD94677.1 - 0.012 16.0 2.2 0.031 14.7 2.2 1.6 1 0 0 1 1 1 0 HMG (high mobility group) box Ax_dynein_light PF10211.9 EGD94677.1 - 0.019 14.9 9.4 0.043 13.8 9.4 1.6 1 0 0 1 1 1 0 Axonemal dynein light chain DUF3450 PF11932.8 EGD94677.1 - 0.14 11.4 11.0 0.37 10.0 9.5 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF3450) DUF4407 PF14362.6 EGD94677.1 - 0.27 10.6 9.8 0.44 9.9 9.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) TolA_bind_tri PF16331.5 EGD94677.1 - 0.33 11.1 5.3 0.071 13.2 1.4 1.9 2 0 0 2 2 2 0 TolA binding protein trimerisation CorA PF01544.18 EGD94677.1 - 0.45 9.8 3.4 0.87 8.8 3.4 1.4 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein Taxilin PF09728.9 EGD94677.1 - 1.3 8.1 15.9 2.3 7.3 15.9 1.3 1 0 0 1 1 1 0 Myosin-like coiled-coil protein NTP_transf_2 PF01909.23 EGD94679.1 - 2e-11 44.0 0.0 4.1e-11 43.0 0.0 1.5 1 0 0 1 1 1 1 Nucleotidyltransferase domain PAP_assoc PF03828.19 EGD94679.1 - 4.2e-11 42.9 0.0 8.1e-11 42.0 0.0 1.5 1 0 0 1 1 1 1 Cid1 family poly A polymerase Polbeta PF18765.1 EGD94679.1 - 0.021 14.9 0.0 0.042 13.9 0.0 1.4 1 0 0 1 1 1 0 Polymerase beta, Nucleotidyltransferase Aldo_ket_red PF00248.21 EGD94680.1 - 2.3e-67 227.3 0.0 2.9e-67 227.0 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family FA_hydroxylase PF04116.13 EGD94681.1 - 6.2e-25 88.1 25.9 2e-24 86.4 22.6 2.1 2 0 0 2 2 2 2 Fatty acid hydroxylase superfamily COX14 PF14880.6 EGD94682.1 - 4.9e-18 64.7 0.0 4.9e-18 64.7 0.0 1.9 2 0 0 2 2 2 1 Cytochrome oxidase c assembly HetR_C PF18460.1 EGD94682.1 - 0.083 12.8 0.0 0.19 11.7 0.0 1.5 1 0 0 1 1 1 0 Heterocyst differentiation regulator C-terminal Hood domain PepSY_TM PF03929.16 EGD94682.1 - 1.7 8.2 5.1 2 8.0 0.0 2.1 1 1 1 2 2 2 0 PepSY-associated TM region Methyltransf_23 PF13489.6 EGD94683.1 - 2.5e-20 73.0 0.0 3.9e-20 72.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EGD94683.1 - 5.7e-10 39.8 0.0 2.5e-09 37.7 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EGD94683.1 - 8.8e-09 35.9 0.0 2.9e-08 34.3 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EGD94683.1 - 1.7e-06 27.9 0.0 1.3e-05 25.0 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EGD94683.1 - 4.3e-06 27.4 0.0 1.5e-05 25.6 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EGD94683.1 - 0.0005 19.5 0.0 0.0011 18.3 0.0 1.5 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family PCMT PF01135.19 EGD94683.1 - 0.036 13.8 0.0 0.092 12.5 0.0 1.6 1 1 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) GidB PF02527.15 EGD94683.1 - 0.037 13.4 0.0 0.1 11.9 0.0 1.6 1 1 0 1 1 1 0 rRNA small subunit methyltransferase G DUF4897 PF16238.5 EGD94683.1 - 0.14 12.0 0.0 0.29 10.9 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4897) HAD_2 PF13419.6 EGD94684.1 - 4.7e-26 91.9 0.0 5.8e-26 91.7 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EGD94684.1 - 3.3e-15 56.9 0.0 9.9e-14 52.1 0.0 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 EGD94684.1 - 6.2e-10 39.8 0.0 1.8e-09 38.3 0.0 1.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EGD94684.1 - 8.5e-09 35.4 0.2 2.3e-08 34.0 0.0 1.8 3 0 0 3 3 3 1 HAD-hyrolase-like Hydrolase_6 PF13344.6 EGD94684.1 - 1.7e-07 31.2 0.0 0.00019 21.5 0.0 2.6 2 1 0 2 2 2 2 Haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 EGD94684.1 - 0.004 16.9 0.0 0.14 11.9 0.0 2.6 3 0 0 3 3 3 1 haloacid dehalogenase-like hydrolase Acid_PPase PF12689.7 EGD94684.1 - 0.0084 16.0 0.1 2.4 8.0 0.0 2.9 3 0 0 3 3 3 1 Acid Phosphatase Acid_phosphat_B PF03767.14 EGD94684.1 - 0.091 12.3 0.0 0.46 10.0 0.0 1.9 2 0 0 2 2 2 0 HAD superfamily, subfamily IIIB (Acid phosphatase) Peptidase_M35 PF02102.15 EGD94685.1 - 6.4e-101 337.8 0.8 7.4e-101 337.6 0.8 1.0 1 0 0 1 1 1 1 Deuterolysin metalloprotease (M35) family Aspzincin_M35 PF14521.6 EGD94685.1 - 7.6e-42 143.3 4.0 1.3e-41 142.5 4.0 1.3 1 0 0 1 1 1 1 Lysine-specific metallo-endopeptidase Glyco_hydro_32N PF00251.20 EGD94685.1 - 0.0079 15.8 0.1 0.011 15.3 0.1 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 32 N-terminal domain Actin PF00022.19 EGD94686.1 - 8e-142 472.6 0.0 9e-142 472.5 0.0 1.0 1 0 0 1 1 1 1 Actin MreB_Mbl PF06723.13 EGD94686.1 - 0.064 12.1 0.0 13 4.5 0.0 2.9 3 0 0 3 3 3 0 MreB/Mbl protein ATG22 PF11700.8 EGD94687.1 - 2.1e-199 663.1 14.4 2.4e-199 662.9 14.4 1.0 1 0 0 1 1 1 1 Vacuole effluxer Atg22 like MFS_1 PF07690.16 EGD94687.1 - 9.7e-07 28.0 48.4 0.0017 17.3 26.0 3.2 2 1 1 3 3 3 3 Major Facilitator Superfamily MFS_2 PF13347.6 EGD94687.1 - 0.0018 16.9 5.4 0.0018 16.9 5.4 2.9 3 0 0 3 3 3 2 MFS/sugar transport protein Mpp10 PF04006.12 EGD94688.1 - 6.1e-111 371.8 62.3 1.4e-109 367.3 62.3 2.0 1 1 0 1 1 1 1 Mpp10 protein HJURP_mid PF12346.8 EGD94688.1 - 0.27 11.7 4.2 1.4 9.4 1.9 2.6 2 0 0 2 2 2 0 Holliday junction recognition protein-associated repeat RepA_C PF04796.12 EGD94688.1 - 0.69 9.9 3.4 0.22 11.5 0.1 1.8 2 0 0 2 2 2 0 Plasmid encoded RepA protein Methyltransf_16 PF10294.9 EGD94689.1 - 3e-46 157.3 0.0 3.9e-46 157.0 0.0 1.1 1 0 0 1 1 1 1 Lysine methyltransferase MTS PF05175.14 EGD94689.1 - 0.0018 17.9 0.0 0.0036 16.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.13 EGD94689.1 - 0.0045 16.4 0.1 0.0073 15.7 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Cons_hypoth95 PF03602.15 EGD94689.1 - 0.022 14.4 0.0 0.03 14.0 0.0 1.3 1 0 0 1 1 1 0 Conserved hypothetical protein 95 CI-B14_5a PF07347.12 EGD94690.1 - 0.086 12.7 0.2 0.22 11.4 0.0 1.8 2 1 0 2 2 2 0 NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a) AhpC-TSA PF00578.21 EGD94691.1 - 6.1e-22 77.8 0.0 9.2e-22 77.3 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 EGD94691.1 - 4.2e-12 46.0 0.0 6.8e-12 45.3 0.0 1.3 1 0 0 1 1 1 1 Redoxin AhpC-TSA_2 PF13911.6 EGD94691.1 - 0.0053 16.9 0.0 0.011 15.8 0.0 1.5 1 0 0 1 1 1 1 AhpC/TSA antioxidant enzyme Spore_coat_CotO PF14153.6 EGD94691.1 - 0.22 11.4 15.3 15 5.4 17.8 2.0 2 0 0 2 2 2 0 Spore coat protein CotO Zip PF02535.22 EGD94691.1 - 0.93 8.6 1.7 0.99 8.6 1.7 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Paf1 PF03985.13 EGD94691.1 - 1.3 8.0 12.8 1.7 7.6 12.8 1.1 1 0 0 1 1 1 0 Paf1 NARP1 PF12569.8 EGD94691.1 - 2.3 7.0 14.7 3.3 6.5 14.7 1.3 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Pox_Ag35 PF03286.14 EGD94691.1 - 2.7 7.7 15.5 4.3 7.1 15.5 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein VIR_N PF15912.5 EGD94691.1 - 4.3 6.9 9.7 5.7 6.5 9.7 1.1 1 0 0 1 1 1 0 Virilizer, N-terminal CDC27 PF09507.10 EGD94691.1 - 6.6 6.0 21.5 8 5.7 21.5 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 CCDC53 PF10152.9 EGD94691.1 - 9.1 6.7 10.8 16 5.9 10.8 1.5 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex CH PF00307.31 EGD94692.1 - 7.8e-74 244.9 0.0 4.8e-20 71.8 0.1 4.2 4 0 0 4 4 4 4 Calponin homology (CH) domain EF-hand_7 PF13499.6 EGD94692.1 - 1.4e-07 31.8 1.5 2.2e-06 28.0 0.6 2.8 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 EGD94692.1 - 0.0001 21.9 0.9 0.013 15.4 0.1 3.1 2 0 0 2 2 2 1 EF-hand domain EF-hand_1 PF00036.32 EGD94692.1 - 0.00024 20.4 2.2 0.66 9.7 0.1 3.7 3 0 0 3 3 3 2 EF hand CAMSAP_CH PF11971.8 EGD94692.1 - 0.0004 20.2 0.0 0.63 9.9 0.0 3.9 4 0 0 4 4 4 1 CAMSAP CH domain EF-hand_5 PF13202.6 EGD94692.1 - 0.49 10.0 1.8 3.9 7.1 0.1 2.7 2 0 0 2 2 2 0 EF hand Hydantoinase_B PF02538.14 EGD94693.1 - 3.6e-221 735.0 0.0 5.4e-221 734.5 0.0 1.3 1 0 0 1 1 1 1 Hydantoinase B/oxoprolinase Hydantoinase_A PF01968.18 EGD94693.1 - 1.7e-92 309.8 1.5 1.7e-92 309.8 1.5 1.8 2 0 0 2 2 2 1 Hydantoinase/oxoprolinase Hydant_A_N PF05378.13 EGD94693.1 - 3.1e-60 202.9 0.6 1.3e-58 197.7 0.0 2.6 2 0 0 2 2 2 1 Hydantoinase/oxoprolinase N-terminal region PC4 PF02229.16 EGD94694.1 - 6.7e-24 83.3 0.1 1e-23 82.7 0.1 1.3 1 0 0 1 1 1 1 Transcriptional Coactivator p15 (PC4) MIT PF04212.18 EGD94695.1 - 2.7e-11 43.4 0.1 6.5e-11 42.1 0.1 1.7 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain Ubiq_cyt_C_chap PF03981.12 EGD94696.1 - 1e-33 116.4 0.3 1.6e-33 115.7 0.3 1.3 1 0 0 1 1 1 1 Ubiquinol-cytochrome C chaperone Peptidase_M24 PF00557.24 EGD94698.1 - 6.8e-57 192.5 0.0 8.8e-57 192.2 0.0 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.16 EGD94698.1 - 1.1e-22 80.1 0.0 2.1e-22 79.2 0.0 1.4 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain TIP41 PF04176.13 EGD94700.1 - 9.2e-71 236.8 0.0 1.1e-70 236.6 0.0 1.1 1 0 0 1 1 1 1 TIP41-like family Pkinase PF00069.25 EGD94701.1 - 2e-58 197.8 0.0 2e-39 135.6 0.0 2.1 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EGD94701.1 - 5.6e-32 111.0 0.0 1.5e-19 70.3 0.0 2.1 1 1 1 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 EGD94701.1 - 2.4e-06 27.1 0.0 3.5e-05 23.3 0.0 2.1 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 EGD94701.1 - 0.061 12.7 0.1 0.1 11.9 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Peptidase_M76 PF09768.9 EGD94702.1 - 6.2e-71 237.7 2.5 7.4e-71 237.4 2.5 1.1 1 0 0 1 1 1 1 Peptidase M76 family SprT-like PF10263.9 EGD94702.1 - 0.00089 19.1 0.7 0.0021 17.9 0.4 1.6 1 1 1 2 2 2 1 SprT-like family Peptidase_M91 PF14891.6 EGD94702.1 - 0.009 16.3 0.0 0.015 15.7 0.0 1.3 1 0 0 1 1 1 1 Effector protein CAF20 PF17052.5 EGD94702.1 - 0.091 12.9 0.0 0.17 12.0 0.0 1.4 1 0 0 1 1 1 0 Cap associated factor Tox-MPTase2 PF15638.6 EGD94702.1 - 0.18 11.5 0.0 0.28 10.9 0.0 1.3 1 0 0 1 1 1 0 Metallopeptidase toxin 2 PALP PF00291.25 EGD94703.1 - 4e-65 220.1 0.1 4.9e-65 219.8 0.1 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme CBS PF00571.28 EGD94703.1 - 4.5e-11 43.0 0.0 5.5e-07 29.9 0.0 3.1 4 0 0 4 4 4 2 CBS domain FIST PF08495.10 EGD94703.1 - 0.13 12.2 0.2 0.77 9.8 0.2 2.3 1 1 0 1 1 1 0 FIST N domain SRPRB PF09439.10 EGD94704.1 - 4.8e-26 91.3 0.1 1.6e-24 86.4 0.1 2.2 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit Arf PF00025.21 EGD94704.1 - 6.1e-07 29.1 0.0 0.0012 18.4 0.0 2.6 2 1 0 2 2 2 2 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EGD94704.1 - 0.00023 21.2 0.0 0.00056 20.0 0.0 1.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_16 PF13191.6 EGD94704.1 - 0.013 15.9 0.3 0.027 14.9 0.2 1.6 1 1 0 1 1 1 0 AAA ATPase domain SRP54 PF00448.22 EGD94704.1 - 0.023 14.3 0.7 0.35 10.5 0.7 2.1 1 1 0 1 1 1 0 SRP54-type protein, GTPase domain Roc PF08477.13 EGD94704.1 - 0.037 14.3 0.1 0.62 10.3 0.1 3.0 3 1 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase PduV-EutP PF10662.9 EGD94704.1 - 0.063 13.0 0.0 0.14 11.9 0.0 1.6 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_29 PF13555.6 EGD94704.1 - 0.081 12.7 0.3 0.38 10.5 0.0 2.1 2 0 0 2 2 2 0 P-loop containing region of AAA domain ATP_bind_1 PF03029.17 EGD94704.1 - 0.13 12.1 0.3 14 5.3 0.2 2.2 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein NACHT PF05729.12 EGD94704.1 - 0.14 12.1 0.0 0.63 9.9 0.0 2.0 2 0 0 2 2 2 0 NACHT domain AAA_22 PF13401.6 EGD94704.1 - 0.2 11.9 0.4 0.46 10.8 0.4 1.8 1 1 0 1 1 1 0 AAA domain Gtr1_RagA PF04670.12 EGD94704.1 - 0.21 10.9 0.0 0.41 10.0 0.0 1.5 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region GPI-anchored PF10342.9 EGD94705.1 - 5.5e-10 39.9 0.1 1.3e-09 38.7 0.0 1.6 2 0 0 2 2 2 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family KRE9 PF05390.11 EGD94705.1 - 1.7e-09 38.4 3.8 2.9e-09 37.6 3.8 1.3 1 0 0 1 1 1 1 Yeast cell wall synthesis protein KRE9/KNH1 AA_kinase PF00696.28 EGD94706.1 - 9.3e-42 143.3 2.6 1.4e-41 142.7 2.6 1.2 1 0 0 1 1 1 1 Amino acid kinase family PUA PF01472.20 EGD94706.1 - 6.2e-12 45.3 0.1 5.6e-11 42.2 0.0 2.4 2 0 0 2 2 2 1 PUA domain Pkinase PF00069.25 EGD94707.1 - 1.5e-41 142.5 0.0 2.5e-40 138.5 0.0 2.2 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD94707.1 - 3.1e-23 82.4 0.0 4.7e-23 81.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EGD94707.1 - 0.031 14.2 0.1 0.06 13.3 0.1 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family AMP-binding PF00501.28 EGD94708.1 - 2.8e-222 737.8 0.0 7.5e-78 262.0 0.0 3.4 3 0 0 3 3 3 3 AMP-binding enzyme Condensation PF00668.20 EGD94708.1 - 1e-147 492.5 0.0 1.6e-34 119.4 0.0 5.8 5 1 0 5 5 5 5 Condensation domain PP-binding PF00550.25 EGD94708.1 - 2.4e-55 184.8 18.6 8.1e-10 38.9 0.2 6.9 6 0 0 6 6 6 6 Phosphopantetheine attachment site AMP-binding_C PF13193.6 EGD94708.1 - 4.6e-14 53.2 0.0 8e-06 26.7 0.0 4.0 3 0 0 3 3 3 2 AMP-binding enzyme C-terminal domain WES_acyltransf PF03007.16 EGD94708.1 - 0.054 13.3 0.3 58 3.3 0.0 3.6 4 0 0 4 4 4 0 Wax ester synthase-like Acyl-CoA acyltransferase domain K_oxygenase PF13434.6 EGD94709.1 - 1.9e-112 375.8 0.0 2.3e-112 375.5 0.0 1.1 1 0 0 1 1 1 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 EGD94709.1 - 6.9e-06 26.1 0.0 0.00016 21.7 0.0 2.5 2 0 0 2 2 2 1 FAD-NAD(P)-binding Pyr_redox_2 PF07992.14 EGD94709.1 - 9.8e-06 25.0 0.0 0.0022 17.3 0.0 2.8 2 2 1 3 3 3 3 Pyridine nucleotide-disulphide oxidoreductase DHHC PF01529.20 EGD94711.1 - 8.7e-36 123.0 10.9 8.7e-36 123.0 10.9 2.6 2 1 0 2 2 2 1 DHHC palmitoyltransferase Ank_2 PF12796.7 EGD94711.1 - 1.3e-28 99.4 0.0 7.3e-10 39.3 0.0 3.7 2 1 2 5 5 5 4 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EGD94711.1 - 1.2e-22 79.7 0.1 5.5e-07 29.7 0.0 4.7 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EGD94711.1 - 4.1e-22 75.9 2.4 1.5e-07 31.2 0.0 6.0 6 0 0 6 6 6 4 Ankyrin repeat Ank_4 PF13637.6 EGD94711.1 - 8.8e-20 70.8 1.7 3e-06 27.7 0.0 5.0 1 1 4 5 5 5 4 Ankyrin repeats (many copies) Ank PF00023.30 EGD94711.1 - 1.5e-19 69.5 0.0 8.8e-07 29.1 0.0 4.8 4 0 0 4 4 4 4 Ankyrin repeat PWI PF01480.17 EGD94712.1 - 2.2e-06 27.9 0.0 4.6e-06 26.8 0.0 1.5 1 0 0 1 1 1 1 PWI domain DUF1542 PF07564.11 EGD94712.1 - 0.37 10.9 2.3 0.73 10.0 2.3 1.5 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1542) OB_NTP_bind PF07717.16 EGD94713.1 - 8.8e-22 77.3 0.0 2.6e-21 75.8 0.0 1.8 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.23 EGD94713.1 - 4.1e-20 72.1 0.0 1e-19 70.8 0.0 1.7 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.31 EGD94713.1 - 1.4e-13 51.2 0.0 2.4e-13 50.4 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Cyt-b5 PF00173.28 EGD94714.1 - 1.1e-20 73.6 0.1 1.2e-20 73.4 0.1 1.0 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain DUF4430 PF14478.6 EGD94714.1 - 0.077 13.6 0.1 0.11 13.1 0.1 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4430) V-ATPase_H_C PF11698.8 EGD94714.1 - 0.12 12.5 0.0 0.42 10.8 0.0 1.8 1 1 1 2 2 2 0 V-ATPase subunit H DUF4291 PF14124.6 EGD94715.1 - 1.2e-72 243.6 0.1 1.4e-72 243.4 0.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4291) Mcp5_PH PF12814.7 EGD94716.1 - 8e-45 151.9 0.8 1.2e-44 151.4 0.0 1.7 2 0 0 2 2 2 1 Meiotic cell cortex C-terminal pleckstrin homology Fez1 PF06818.15 EGD94716.1 - 0.004 17.6 11.8 0.004 17.6 11.8 1.7 1 1 0 1 1 1 1 Fez1 DUF3584 PF12128.8 EGD94716.1 - 0.12 9.9 12.4 0.17 9.4 12.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) TPR_MLP1_2 PF07926.12 EGD94716.1 - 0.28 11.2 17.6 5.4 7.1 15.7 2.5 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein AMP-binding PF00501.28 EGD94717.1 - 6.7e-73 245.7 0.0 8.9e-73 245.3 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme ACAS_N PF16177.5 EGD94717.1 - 1.2e-15 57.2 0.1 2.7e-15 56.0 0.1 1.7 1 0 0 1 1 1 1 Acetyl-coenzyme A synthetase N-terminus AMP-binding_C PF13193.6 EGD94717.1 - 4.4e-15 56.4 0.1 1.5e-14 54.8 0.0 2.0 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain Ras PF00071.22 EGD94719.1 - 3.3e-50 169.8 0.5 7.1e-49 165.5 0.5 2.0 1 1 0 1 1 1 1 Ras family Roc PF08477.13 EGD94719.1 - 4.1e-18 65.7 0.1 8.8e-17 61.4 0.0 2.3 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EGD94719.1 - 0.00022 20.8 0.0 0.0017 17.9 0.0 2.0 2 0 0 2 2 2 1 ADP-ribosylation factor family SUIM_assoc PF16619.5 EGD94719.1 - 0.0075 16.3 1.6 0.017 15.2 1.6 1.5 1 0 0 1 1 1 1 Unstructured region C-term to UIM in Ataxin3 AAA_16 PF13191.6 EGD94719.1 - 0.089 13.2 0.3 0.19 12.1 0.3 1.8 1 1 0 1 1 1 0 AAA ATPase domain Septin PF00735.18 EGD94719.1 - 0.12 11.6 0.6 0.2 10.9 0.0 1.6 2 0 0 2 2 2 0 Septin RsgA_GTPase PF03193.16 EGD94719.1 - 0.14 12.1 0.0 9.5 6.1 0.0 2.6 2 1 1 3 3 3 0 RsgA GTPase AAA_25 PF13481.6 EGD94719.1 - 0.14 11.7 0.1 0.34 10.5 0.1 1.6 1 1 0 1 1 1 0 AAA domain FeoB_N PF02421.18 EGD94719.1 - 0.15 11.6 0.2 2.6 7.5 0.0 2.4 2 1 1 3 3 3 0 Ferrous iron transport protein B MFS_1 PF07690.16 EGD94720.1 - 2.6e-35 122.0 33.7 3.7e-35 121.5 33.7 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily SH PF01445.17 EGD94720.1 - 0.018 15.0 0.0 0.069 13.1 0.0 2.0 1 0 0 1 1 1 0 Viral small hydrophobic protein SHMT PF00464.19 EGD94723.1 - 4.7e-196 651.1 0.0 5.4e-196 650.9 0.0 1.0 1 0 0 1 1 1 1 Serine hydroxymethyltransferase Mor PF08765.11 EGD94723.1 - 0.052 13.5 0.0 0.13 12.3 0.0 1.6 1 0 0 1 1 1 0 Mor transcription activator family MOSC PF03473.17 EGD94724.1 - 2.3e-34 118.2 0.0 3.5e-34 117.7 0.0 1.3 1 0 0 1 1 1 1 MOSC domain MOSC_N PF03476.16 EGD94724.1 - 4.1e-13 49.3 0.0 1.2e-12 47.7 0.0 1.8 1 1 0 1 1 1 1 MOSC N-terminal beta barrel domain DUF2235 PF09994.9 EGD94725.1 - 7.7e-92 307.7 0.1 9.5e-92 307.4 0.1 1.1 1 0 0 1 1 1 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) Patatin PF01734.22 EGD94726.1 - 2.5e-15 57.2 0.0 1.1e-14 55.1 0.0 2.0 2 1 0 2 2 2 1 Patatin-like phospholipase Mg_trans_NIPA PF05653.14 EGD94727.1 - 5.9e-85 284.9 19.9 8.4e-85 284.4 19.9 1.1 1 0 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.20 EGD94727.1 - 3.4e-05 24.0 6.1 3.4e-05 24.0 6.1 3.2 3 0 0 3 3 3 2 EamA-like transporter family DUF1435 PF07256.12 EGD94727.1 - 0.23 11.6 1.9 0.38 10.9 0.0 2.3 2 1 1 3 3 3 0 Protein of unknown function (DUF1435) PTCB-BRCT PF12738.7 EGD94728.1 - 3.5e-05 23.6 0.4 0.00014 21.7 0.0 2.1 2 0 0 2 2 2 1 twin BRCT domain BRCT_2 PF16589.5 EGD94728.1 - 0.0066 16.8 0.0 0.012 16.0 0.0 1.4 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 EGD94728.1 - 0.15 12.5 0.0 0.27 11.7 0.0 1.6 1 0 0 1 1 1 0 BRCA1 C Terminus (BRCT) domain KilA-N PF04383.13 EGD94730.1 - 0.0005 19.9 0.0 0.0081 16.0 0.0 2.3 1 1 0 1 1 1 1 KilA-N domain HA2 PF04408.23 EGD94734.1 - 1.4e-16 60.7 0.0 3.6e-16 59.4 0.0 1.7 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.31 EGD94734.1 - 3.5e-13 49.9 0.0 7.9e-13 48.7 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 EGD94734.1 - 3.3e-11 43.3 0.0 7.1e-11 42.2 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 EGD94734.1 - 1.5e-07 31.7 0.2 3.2e-06 27.5 0.1 2.8 2 0 0 2 2 2 1 AAA domain OB_NTP_bind PF07717.16 EGD94734.1 - 9.2e-06 25.9 0.0 2.2e-05 24.7 0.0 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold AAA_23 PF13476.6 EGD94734.1 - 0.0018 18.8 1.1 0.0042 17.6 0.0 2.2 2 0 0 2 2 1 1 AAA domain T2SSE PF00437.20 EGD94734.1 - 0.0046 16.0 0.0 0.009 15.1 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein FtsK_SpoIIIE PF01580.18 EGD94734.1 - 0.0096 15.3 0.1 0.035 13.5 0.0 1.9 2 0 0 2 2 2 1 FtsK/SpoIIIE family AAA_19 PF13245.6 EGD94734.1 - 0.031 14.6 0.0 0.1 12.9 0.0 1.9 1 1 0 1 1 1 0 AAA domain AAA_29 PF13555.6 EGD94734.1 - 0.051 13.3 0.0 0.13 12.0 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF494 PF04361.13 EGD94734.1 - 0.06 13.2 0.1 13 5.7 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF494) ATPase PF06745.13 EGD94734.1 - 0.094 12.0 0.1 0.37 10.1 0.0 2.0 2 0 0 2 2 2 0 KaiC ABC_tran PF00005.27 EGD94734.1 - 0.1 13.1 1.5 0.33 11.5 0.1 2.5 2 1 1 3 3 3 0 ABC transporter RuvA_C PF07499.13 EGD94734.1 - 1.9 9.0 4.3 2.1 8.9 0.1 3.1 4 0 0 4 4 3 0 RuvA, C-terminal domain Gcn1_N PF12074.8 EGD94735.1 - 1.4e-114 383.1 1.4 7.4e-114 380.8 0.1 3.2 2 0 0 2 2 2 1 Generalcontrol nonderepressible 1 (Gcn1) N-terminal HEAT PF02985.22 EGD94735.1 - 1.5e-28 96.4 37.8 0.48 10.8 0.1 22.3 24 0 0 24 24 23 7 HEAT repeat HEAT_2 PF13646.6 EGD94735.1 - 2.1e-20 72.9 37.1 1.6e-05 25.2 0.0 13.4 9 4 6 15 15 14 8 HEAT repeats HEAT_EZ PF13513.6 EGD94735.1 - 2.7e-19 69.3 42.6 3.8e-07 30.5 0.0 18.4 23 0 0 23 23 17 3 HEAT-like repeat Vac14_Fab1_bd PF12755.7 EGD94735.1 - 1.3e-12 48.2 0.0 0.24 12.0 0.0 8.1 6 1 2 8 8 8 3 Vacuolar 14 Fab1-binding region Cnd1 PF12717.7 EGD94735.1 - 2.1e-11 44.1 15.0 0.0099 15.9 0.2 8.7 7 2 1 8 8 8 2 non-SMC mitotic condensation complex subunit 1 ParcG PF10274.9 EGD94735.1 - 2.5e-07 31.0 7.3 0.18 11.9 0.0 6.8 6 1 1 7 7 7 2 Parkin co-regulated protein TIP120 PF08623.10 EGD94735.1 - 6.9e-07 29.2 1.0 0.01 15.6 0.0 6.1 6 0 0 6 6 6 1 TATA-binding protein interacting (TIP20) CLASP_N PF12348.8 EGD94735.1 - 1.1e-06 28.4 0.1 1.6 8.3 0.0 6.7 5 1 1 6 6 6 1 CLASP N terminal Adaptin_N PF01602.20 EGD94735.1 - 0.0013 17.4 14.5 2.1 6.8 0.0 6.2 6 1 1 7 7 7 3 Adaptin N terminal region DUF937 PF06078.11 EGD94735.1 - 0.0014 19.2 2.3 6.6 7.3 0.0 5.3 3 1 1 4 4 4 1 Bacterial protein of unknown function (DUF937) Pes-10 PF07149.11 EGD94735.1 - 0.059 12.4 0.1 0.16 11.0 0.1 1.7 1 0 0 1 1 1 0 Pes-10 RasGEF_N_2 PF14663.6 EGD94735.1 - 0.069 13.5 0.8 16 5.9 0.0 4.5 4 0 0 4 4 3 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain FANCI_S2 PF14676.6 EGD94735.1 - 0.6 10.4 7.9 9.7 6.5 0.1 4.7 5 0 0 5 5 4 0 FANCI solenoid 2 DCB PF16213.5 EGD94735.1 - 0.7 9.5 3.6 24 4.6 0.1 4.4 4 0 0 4 4 4 0 Dimerisation and cyclophilin-binding domain of Mon2 IFRD PF05004.13 EGD94735.1 - 1.1 8.3 23.2 0.58 9.2 0.1 6.6 7 0 0 7 7 7 0 Interferon-related developmental regulator (IFRD) Tti2 PF10521.9 EGD94735.1 - 1.6 8.2 10.3 19 4.7 0.0 5.8 7 1 1 8 8 8 0 Tti2 family RTP1_C1 PF10363.9 EGD94735.1 - 3.2 8.0 10.3 61 3.9 0.0 6.5 7 0 0 7 7 7 0 Required for nuclear transport of RNA pol II C-terminus 1 Ribosomal_L19e PF01280.20 EGD94736.1 - 6.6e-62 207.8 7.1 6.6e-62 207.8 7.1 1.8 1 1 1 2 2 2 1 Ribosomal protein L19e DUF4239 PF14023.6 EGD94736.1 - 0.12 12.1 1.4 0.21 11.3 1.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4239) TRAP-gamma PF07074.12 EGD94736.1 - 0.19 11.3 3.5 0.28 10.7 3.5 1.2 1 0 0 1 1 1 0 Translocon-associated protein, gamma subunit (TRAP-gamma) Zn_clus PF00172.18 EGD94742.1 - 1.6e-09 37.7 11.0 2.7e-09 37.0 11.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain N_NLPC_P60 PF12912.7 EGD94743.1 - 0.018 15.4 1.5 2.1 8.8 0.0 2.1 2 0 0 2 2 2 0 NLPC_P60 stabilising domain, N term adh_short PF00106.25 EGD94744.1 - 6.4e-36 123.6 0.1 9e-36 123.2 0.1 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EGD94744.1 - 1.2e-27 97.0 0.0 1.7e-27 96.5 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EGD94744.1 - 4.3e-09 36.5 2.2 4.6e-07 29.9 3.1 2.8 1 1 1 2 2 2 1 KR domain Epimerase PF01370.21 EGD94744.1 - 3.8e-05 23.3 0.0 6.2e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 EGD94744.1 - 0.0047 16.1 0.0 0.007 15.5 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain UPF0146 PF03686.13 EGD94744.1 - 0.015 15.1 0.0 0.03 14.2 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0146) DUF3216 PF11505.8 EGD94744.1 - 0.2 11.9 0.0 0.44 10.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3216) CorA PF01544.18 EGD94746.1 - 3.3e-40 138.2 0.4 7.9e-40 137.0 0.4 1.6 1 1 0 1 1 1 1 CorA-like Mg2+ transporter protein Vac7 PF12751.7 EGD94747.1 - 6.4e-137 457.0 0.5 6.4e-137 457.0 0.5 3.1 2 1 2 4 4 4 1 Vacuolar segregation subunit 7 EIIBC-GUT_N PF03612.14 EGD94747.1 - 0.17 11.6 1.1 0.36 10.6 1.1 1.4 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus DUF3824 PF12868.7 EGD94750.1 - 1.1e-14 55.3 32.2 1.1e-14 55.3 32.2 11.3 3 2 7 10 10 10 1 Domain of unknwon function (DUF3824) NDUF_B12 PF08122.12 EGD94750.1 - 0.0051 16.8 1.0 0.36 10.9 0.0 3.6 3 1 1 4 4 4 1 NADH-ubiquinone oxidoreductase B12 subunit family DUF4473 PF14747.6 EGD94750.1 - 0.084 13.4 5.1 1.9 9.1 0.1 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4473) CbtA PF09490.10 EGD94750.1 - 0.39 10.5 1.9 0.82 9.4 0.1 2.5 3 0 0 3 3 3 0 Probable cobalt transporter subunit (CbtA) GNAT_acetyltr_2 PF13718.6 EGD94750.1 - 8.2 5.8 8.2 1.1 8.7 0.4 2.4 2 0 0 2 2 2 0 GNAT acetyltransferase 2 Amidohydro_1 PF01979.20 EGD94751.1 - 1.6e-18 67.2 2.0 2.2e-18 66.7 2.0 1.2 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 EGD94751.1 - 2.2e-13 50.5 4.5 1.2e-11 44.8 0.9 2.2 1 1 0 2 2 2 2 Amidohydrolase family LIP1 PF15904.5 EGD94752.1 - 0.073 13.4 0.0 0.1 12.9 0.0 1.3 1 0 0 1 1 1 0 LKB1 serine/threonine kinase interacting protein 1 Abhydrolase_1 PF00561.20 EGD94753.1 - 8e-22 78.1 0.0 1.7e-18 67.2 0.0 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EGD94753.1 - 5.7e-19 69.6 0.2 7.1e-19 69.3 0.2 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EGD94753.1 - 1.4e-18 67.1 0.0 2.1e-18 66.5 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Ndr PF03096.14 EGD94753.1 - 2e-05 23.4 0.0 2.5e-05 23.1 0.0 1.1 1 0 0 1 1 1 1 Ndr family Thioesterase PF00975.20 EGD94753.1 - 0.00032 20.9 0.1 0.00056 20.1 0.0 1.3 1 1 0 1 1 1 1 Thioesterase domain PGAP1 PF07819.13 EGD94753.1 - 0.032 14.0 0.9 1.5 8.5 0.8 2.3 1 1 0 1 1 1 0 PGAP1-like protein Fungal_trans PF04082.18 EGD94754.1 - 3.6e-15 55.7 1.2 7.8e-15 54.6 0.3 2.0 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EGD94754.1 - 6.1e-08 32.7 5.3 1.1e-07 31.8 5.3 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain 2-oxogl_dehyd_N PF16078.5 EGD94754.1 - 0.0065 16.0 0.0 0.017 14.7 0.0 1.6 1 0 0 1 1 1 1 2-oxoglutarate dehydrogenase N-terminus Spore_YpjB PF09577.10 EGD94754.1 - 0.078 12.8 0.1 0.16 11.8 0.1 1.4 1 0 0 1 1 1 0 Sporulation protein YpjB (SpoYpjB) Ribosomal_L44 PF00935.19 EGD94755.1 - 5.7e-36 122.8 12.1 9e-36 122.2 12.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L44 Cathelicidins PF00666.17 EGD94755.1 - 0.74 10.2 4.7 0.15 12.4 1.2 1.6 2 0 0 2 2 2 0 Cathelicidin ubiquitin PF00240.23 EGD94756.1 - 6.8e-24 83.4 0.0 7.6e-24 83.3 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 EGD94756.1 - 4.1e-13 48.9 0.0 4.5e-13 48.8 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EGD94756.1 - 9.9e-05 22.7 0.0 0.00029 21.2 0.0 1.7 1 1 0 1 1 1 1 Ubiquitin-like domain TBK1_ULD PF18396.1 EGD94756.1 - 0.012 15.5 0.0 0.014 15.3 0.0 1.1 1 0 0 1 1 1 0 TANK binding kinase 1 ubiquitin-like domain Ferritin_2 PF13668.6 EGD94757.1 - 2.9e-17 63.1 0.0 4.3e-17 62.6 0.0 1.2 1 0 0 1 1 1 1 Ferritin-like domain PilN PF05137.13 EGD94757.1 - 0.042 14.0 0.2 2.6 8.2 0.1 2.4 2 0 0 2 2 2 0 Fimbrial assembly protein (PilN) Rav1p_C PF12234.8 EGD94758.1 - 2.8e-283 941.2 0.0 4e-283 940.7 0.0 1.2 1 0 0 1 1 1 1 RAVE protein 1 C terminal Nup160 PF11715.8 EGD94758.1 - 0.69 8.5 5.1 2.6 6.6 0.2 2.6 3 0 0 3 3 3 0 Nucleoporin Nup120/160 WD40 PF00400.32 EGD94758.1 - 2.5 9.1 16.8 20 6.2 0.5 5.8 6 1 1 7 7 7 0 WD domain, G-beta repeat OPT PF03169.15 EGD94759.1 - 2.3e-161 538.6 20.3 2.6e-161 538.4 20.3 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein SH3_9 PF14604.6 EGD94760.1 - 3.5e-08 33.2 0.0 5.5e-08 32.6 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EGD94760.1 - 4.1e-06 26.3 0.0 6.5e-06 25.7 0.0 1.3 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 EGD94760.1 - 1.8e-05 24.3 0.0 3e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain Podoplanin PF05808.11 EGD94760.1 - 9.1e-05 22.6 0.2 0.00021 21.4 0.2 1.6 1 0 0 1 1 1 1 Podoplanin Pup PF05639.11 EGD94760.1 - 1.1 10.2 2.3 1.4 9.8 0.0 2.3 2 0 0 2 2 2 0 Pup-like protein DUF4366 PF14283.6 EGD94760.1 - 2.8 8.0 6.7 3.1 7.8 0.0 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4366) Pkinase PF00069.25 EGD94762.1 - 9.4e-37 126.8 0.0 1.4e-36 126.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD94762.1 - 1.3e-13 50.8 0.0 1.9e-13 50.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EGD94762.1 - 0.0033 16.3 0.0 0.0051 15.6 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EGD94762.1 - 0.0062 16.5 0.1 0.022 14.7 0.1 1.7 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.6 EGD94762.1 - 0.012 14.9 0.0 0.02 14.2 0.0 1.3 1 0 0 1 1 1 0 Kinase-like FTA2 PF13095.6 EGD94762.1 - 0.018 14.7 0.0 0.027 14.1 0.0 1.2 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 EGD94762.1 - 0.018 14.4 0.0 0.029 13.7 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family KIX_2 PF16987.5 EGD94762.1 - 0.022 14.7 0.0 0.04 13.9 0.0 1.4 1 0 0 1 1 1 0 KIX domain muHD PF10291.9 EGD94763.1 - 2.5e-74 250.0 0.0 3.6e-74 249.5 0.0 1.2 1 0 0 1 1 1 1 Muniscin C-terminal mu homology domain FCH PF00611.23 EGD94763.1 - 3.2e-08 33.7 0.2 1.3e-07 31.8 0.0 2.2 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain Laminin_II PF06009.12 EGD94763.1 - 0.084 12.9 5.0 0.058 13.4 2.5 2.2 2 0 0 2 2 2 0 Laminin Domain II Spc7 PF08317.11 EGD94763.1 - 1.3 7.9 5.4 2.2 7.1 5.4 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein Peptidase_M20 PF01546.28 EGD94764.1 - 1.5e-27 96.7 0.3 3.9e-27 95.3 0.1 1.8 2 1 0 2 2 2 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 EGD94764.1 - 2.6e-18 65.9 0.0 8.6e-18 64.3 0.0 1.9 1 1 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 EGD94764.1 - 0.00029 20.6 0.0 0.00086 19.0 0.0 1.8 2 0 0 2 2 2 1 Peptidase family M28 MAD PF05557.13 EGD94765.1 - 6.3e-59 200.0 75.0 1.5e-50 172.3 76.1 2.2 2 0 0 2 2 2 2 Mitotic checkpoint protein CC2-LZ PF16516.5 EGD94765.1 - 0.13 12.6 0.1 0.13 12.6 0.1 9.1 4 2 2 6 6 6 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator YojJ PF10372.9 EGD94765.1 - 1.2 9.3 6.8 1.1 9.4 0.4 4.1 3 0 0 3 3 3 0 Bacterial membrane-spanning protein N-terminus Arginosuc_synth PF00764.19 EGD94766.1 - 3e-143 477.8 0.0 3.6e-143 477.5 0.0 1.0 1 0 0 1 1 1 1 Arginosuccinate synthase QueC PF06508.13 EGD94766.1 - 0.0031 17.0 0.0 0.0047 16.4 0.0 1.3 1 0 0 1 1 1 1 Queuosine biosynthesis protein QueC tRNA_Me_trans PF03054.16 EGD94766.1 - 0.02 13.7 0.0 0.029 13.2 0.0 1.2 1 0 0 1 1 1 0 tRNA methyl transferase Asn_synthase PF00733.21 EGD94766.1 - 0.06 13.0 0.0 0.072 12.7 0.0 1.1 1 0 0 1 1 1 0 Asparagine synthase DNA_pol3_gamma3 PF12169.8 EGD94766.1 - 0.15 11.9 0.1 0.46 10.4 0.0 1.7 2 0 0 2 2 2 0 DNA polymerase III subunits gamma and tau domain III RasGEF PF00617.19 EGD94768.1 - 6e-42 143.8 0.3 9.3e-42 143.2 0.3 1.3 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 EGD94768.1 - 1.7e-13 50.7 0.1 4.1e-13 49.5 0.1 1.6 1 0 0 1 1 1 1 RasGEF N-terminal motif DIL PF01843.19 EGD94769.1 - 6.1e-18 65.0 0.8 6.1e-18 65.0 0.8 2.0 2 0 0 2 2 2 1 DIL domain Ank_2 PF12796.7 EGD94769.1 - 1.2e-13 51.5 0.1 7.2e-13 48.9 0.0 2.3 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EGD94769.1 - 1e-09 38.4 0.0 5.8e-05 23.3 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 EGD94769.1 - 5.1e-09 36.2 0.7 0.0061 16.9 0.0 3.9 4 0 0 4 4 4 2 Ankyrin repeat Ank_4 PF13637.6 EGD94769.1 - 8.9e-08 32.5 0.5 0.00029 21.3 0.1 4.5 2 1 2 4 4 4 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EGD94769.1 - 1.1e-06 28.5 1.4 0.011 16.2 0.0 4.7 4 1 0 4 4 4 1 Ankyrin repeat BTB PF00651.31 EGD94771.1 - 1.2e-17 64.1 0.1 1.7e-17 63.6 0.1 1.2 1 0 0 1 1 1 1 BTB/POZ domain SKG6 PF08693.10 EGD94772.1 - 3.7e-06 26.2 0.3 6.7e-06 25.4 0.3 1.4 1 0 0 1 1 1 1 Transmembrane alpha-helix domain RabGAP-TBC PF00566.18 EGD94773.1 - 1.3e-35 123.0 0.0 2.2e-35 122.3 0.0 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain DPCD PF14913.6 EGD94773.1 - 0.022 14.1 0.2 0.047 13.1 0.2 1.5 1 0 0 1 1 1 0 DPCD protein family TPP_enzyme_N PF02776.18 EGD94774.1 - 3.2e-40 137.6 0.0 6.5e-40 136.5 0.0 1.6 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.21 EGD94774.1 - 1.2e-17 64.1 0.0 4.6e-17 62.2 0.0 1.9 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.22 EGD94774.1 - 5.6e-14 52.0 0.0 1.1e-13 51.2 0.0 1.4 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain Mo25 PF08569.11 EGD94775.1 - 4.5e-133 443.7 0.0 5.1e-133 443.5 0.0 1.0 1 0 0 1 1 1 1 Mo25-like Methyltransf_25 PF13649.6 EGD94776.1 - 4.2e-10 40.2 0.0 1.3e-09 38.6 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 EGD94776.1 - 1.1e-08 34.9 0.0 1.8e-08 34.2 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_31 PF13847.6 EGD94776.1 - 1.6e-08 34.4 0.0 3.2e-08 33.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EGD94776.1 - 2.1e-08 34.7 0.0 5.1e-08 33.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EGD94776.1 - 1.7e-05 24.7 0.0 3e-05 23.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.7 EGD94776.1 - 3.8e-05 23.7 0.0 7.6e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EGD94776.1 - 0.00021 20.9 0.1 0.00037 20.1 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_9 PF08003.11 EGD94776.1 - 0.0011 18.0 0.0 0.0015 17.5 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) RasGAP_C PF03836.15 EGD94776.1 - 0.014 15.6 0.4 0.027 14.6 0.4 1.4 1 0 0 1 1 1 0 RasGAP C-terminus TehB PF03848.14 EGD94776.1 - 0.015 14.7 0.0 0.024 14.0 0.0 1.3 1 0 0 1 1 1 0 Tellurite resistance protein TehB Methyltransf_12 PF08242.12 EGD94776.1 - 0.029 15.1 0.0 0.067 13.9 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain CMAS PF02353.20 EGD94776.1 - 0.041 13.2 0.1 0.22 10.8 0.0 2.1 3 0 0 3 3 3 0 Mycolic acid cyclopropane synthetase PCMT PF01135.19 EGD94776.1 - 0.044 13.5 0.0 0.1 12.3 0.0 1.6 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_24 PF13578.6 EGD94776.1 - 0.05 14.6 0.0 0.13 13.3 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain Ubie_methyltran PF01209.18 EGD94776.1 - 0.11 11.9 0.0 0.18 11.1 0.0 1.3 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_32 PF13679.6 EGD94776.1 - 0.2 11.6 0.0 0.42 10.6 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Cir_N PF10197.9 EGD94777.1 - 1.6e-06 28.2 8.4 1.6e-06 28.2 8.4 5.5 5 1 0 5 5 5 1 N-terminal domain of CBF1 interacting co-repressor CIR AAA PF00004.29 EGD94778.1 - 9.2e-27 94.1 0.0 4.7e-12 46.5 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EGD94778.1 - 9.6e-11 41.3 0.0 2.2e-10 40.2 0.0 1.6 1 0 0 1 1 1 1 AAA+ lid domain CDC48_2 PF02933.17 EGD94778.1 - 7.1e-10 38.5 0.1 2.1e-08 33.8 0.0 2.7 2 0 0 2 2 2 1 Cell division protein 48 (CDC48), domain 2 CDC48_N PF02359.18 EGD94778.1 - 7e-08 32.5 0.0 1.8e-07 31.2 0.0 1.7 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), N-terminal domain AAA_16 PF13191.6 EGD94778.1 - 0.0015 18.9 0.0 0.0069 16.8 0.0 2.1 2 0 0 2 2 2 1 AAA ATPase domain AAA_14 PF13173.6 EGD94778.1 - 0.0016 18.4 0.0 0.086 12.9 0.0 2.5 2 0 0 2 2 2 1 AAA domain RuvB_N PF05496.12 EGD94778.1 - 0.0027 17.5 0.0 0.0075 16.0 0.0 1.8 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain TIP49 PF06068.13 EGD94778.1 - 0.0039 16.4 0.0 0.0067 15.7 0.0 1.3 1 0 0 1 1 1 1 TIP49 P-loop domain NACHT PF05729.12 EGD94778.1 - 0.011 15.6 0.4 0.028 14.3 0.0 1.8 2 0 0 2 2 1 0 NACHT domain AAA_33 PF13671.6 EGD94778.1 - 0.015 15.5 0.0 0.03 14.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 EGD94778.1 - 0.016 15.8 0.0 0.31 11.6 0.0 2.4 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 EGD94778.1 - 0.025 14.9 0.0 0.06 13.7 0.0 1.6 1 0 0 1 1 1 0 RNA helicase AAA_22 PF13401.6 EGD94778.1 - 0.028 14.7 0.0 0.43 10.8 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.14 EGD94778.1 - 0.032 14.2 0.0 0.087 12.8 0.0 1.8 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) NB-ARC PF00931.22 EGD94778.1 - 0.036 13.3 0.0 0.096 11.8 0.0 1.6 2 0 0 2 2 2 0 NB-ARC domain AAA_17 PF13207.6 EGD94778.1 - 0.04 14.3 0.1 0.16 12.4 0.0 2.0 2 0 0 2 2 2 0 AAA domain Vps4_C PF09336.10 EGD94778.1 - 0.048 13.7 0.0 0.21 11.6 0.0 2.1 1 0 0 1 1 1 0 Vps4 C terminal oligomerisation domain Mg_chelatase PF01078.21 EGD94778.1 - 0.061 12.7 0.0 0.12 11.7 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI KxDL PF10241.9 EGD94780.1 - 6.2e-23 80.9 0.2 7.8e-23 80.6 0.2 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein HATPase_c PF02518.26 EGD94781.1 - 3e-21 76.0 0.8 9.1e-21 74.5 0.1 2.1 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 EGD94781.1 - 6.7e-19 68.1 0.1 1.3e-18 67.2 0.1 1.5 1 0 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.25 EGD94781.1 - 8.3e-16 57.8 0.0 2.6e-15 56.2 0.0 1.9 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain PAS_3 PF08447.12 EGD94781.1 - 2.2e-11 43.9 1.0 0.00091 19.5 0.1 3.9 3 0 0 3 3 3 3 PAS fold PAS_4 PF08448.10 EGD94781.1 - 9.6e-06 25.8 0.2 4e-05 23.8 0.0 2.2 2 0 0 2 2 2 1 PAS fold PAS PF00989.25 EGD94781.1 - 0.0022 18.0 3.3 0.33 11.0 0.0 3.7 4 0 0 4 4 4 2 PAS fold PAS_9 PF13426.7 EGD94781.1 - 0.014 15.6 0.1 6.1 7.2 0.0 3.9 4 0 0 4 4 4 0 PAS domain MotA_ExbB PF01618.16 EGD94781.1 - 0.59 9.9 1.7 0.89 9.3 0.0 2.1 2 0 0 2 2 2 0 MotA/TolQ/ExbB proton channel family F-protein PF00469.20 EGD94781.1 - 4.1 6.9 8.5 9.2 5.8 8.5 1.6 1 0 0 1 1 1 0 Negative factor, (F-Protein) or Nef DUF883 PF05957.13 EGD94781.1 - 10 6.8 8.4 6.7 7.4 2.9 3.2 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF883) HATPase_c PF02518.26 EGD94782.1 - 1.9e-31 108.9 0.1 5.9e-31 107.3 0.0 1.9 2 0 0 2 2 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 EGD94782.1 - 8.9e-20 70.9 0.1 2.6e-19 69.4 0.1 1.9 1 0 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.25 EGD94782.1 - 2.4e-19 69.1 0.0 1.4e-18 66.7 0.0 2.5 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain GAF_2 PF13185.6 EGD94782.1 - 7.9e-10 39.2 0.0 3.8e-09 36.9 0.0 2.3 1 0 0 1 1 1 1 GAF domain AAA_16 PF13191.6 EGD94782.1 - 1.6e-09 38.3 0.1 1.2e-08 35.5 0.0 2.6 2 0 0 2 2 1 1 AAA ATPase domain GAF PF01590.26 EGD94782.1 - 1.2e-06 29.2 0.0 3.6e-06 27.7 0.0 1.9 1 0 0 1 1 1 1 GAF domain Pkinase PF00069.25 EGD94782.1 - 5.3e-06 26.0 0.0 8.3e-05 22.1 0.0 2.3 2 0 0 2 2 2 1 Protein kinase domain GAF_3 PF13492.6 EGD94782.1 - 1.8e-05 25.1 0.0 4.6e-05 23.8 0.0 1.7 1 0 0 1 1 1 1 GAF domain HATPase_c_3 PF13589.6 EGD94782.1 - 6e-05 22.9 0.0 0.00016 21.5 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase NB-ARC PF00931.22 EGD94782.1 - 0.0001 21.6 0.0 0.025 13.8 0.0 3.2 3 0 0 3 3 3 1 NB-ARC domain AAA_22 PF13401.6 EGD94782.1 - 0.018 15.3 0.0 1.3 9.3 0.0 3.3 3 0 0 3 3 3 0 AAA domain MeaB PF03308.16 EGD94782.1 - 0.024 13.6 0.0 0.048 12.6 0.0 1.4 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB TPR_2 PF07719.17 EGD94782.1 - 0.067 13.3 2.8 6 7.2 0.1 3.6 3 0 0 3 3 2 0 Tetratricopeptide repeat AAA_35 PF14516.6 EGD94782.1 - 0.089 11.6 0.0 0.27 10.0 0.0 1.7 2 0 0 2 2 2 0 AAA-like domain DUF3369 PF11849.8 EGD94782.1 - 0.13 12.5 0.0 0.32 11.2 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3369) AAA_33 PF13671.6 EGD94782.1 - 0.14 12.3 0.0 1.6 8.9 0.0 2.5 2 0 0 2 2 2 0 AAA domain RsgA_GTPase PF03193.16 EGD94782.1 - 0.17 11.8 0.2 0.66 9.9 0.0 2.0 2 0 0 2 2 2 0 RsgA GTPase Allantoicase PF03561.15 EGD94783.1 - 1.9e-85 284.1 0.0 1.7e-41 141.5 0.0 2.0 2 0 0 2 2 2 2 Allantoicase repeat Cytochrom_B561 PF03188.16 EGD94784.1 - 1.2e-16 61.1 2.0 1.2e-16 61.1 2.0 1.6 1 1 0 1 1 1 1 Eukaryotic cytochrome b561 DUF4079 PF13301.6 EGD94784.1 - 0.012 15.8 2.7 0.012 15.8 2.7 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF4079) Ni_hydr_CYTB PF01292.20 EGD94784.1 - 0.034 13.7 6.5 0.44 10.1 6.5 2.3 1 1 0 1 1 1 0 Prokaryotic cytochrome b561 Bax1-I PF01027.20 EGD94784.1 - 0.041 13.7 13.0 0.053 13.3 6.3 2.2 1 1 1 2 2 2 0 Inhibitor of apoptosis-promoting Bax1 DUF2306 PF10067.9 EGD94784.1 - 0.051 13.8 7.0 0.35 11.1 0.6 2.2 1 1 1 2 2 2 0 Predicted membrane protein (DUF2306) TctB PF07331.11 EGD94784.1 - 0.13 12.5 11.3 1.7 8.9 0.8 2.4 1 1 1 2 2 2 0 Tripartite tricarboxylate transporter TctB family DUF2427 PF10348.9 EGD94784.1 - 0.14 12.0 4.8 1.2 9.0 0.6 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF2427) DUF4271 PF14093.6 EGD94784.1 - 0.33 10.8 5.9 0.3 11.0 5.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4271) DUF1129 PF06570.11 EGD94784.1 - 0.5 9.8 4.4 1 8.8 4.2 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1129) tRNA-synt_2b PF00587.25 EGD94785.1 - 6.5e-20 71.8 0.0 2.1e-19 70.2 0.0 1.8 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.22 EGD94785.1 - 2.8e-08 34.0 3.2 5.5e-08 33.0 3.2 1.4 1 0 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain FapA PF03961.13 EGD94785.1 - 0.0016 17.2 4.9 0.0023 16.6 4.9 1.1 1 0 0 1 1 1 1 Flagellar Assembly Protein A tRNA-synt_His PF13393.6 EGD94785.1 - 0.014 14.7 1.6 0.51 9.6 1.7 2.2 2 0 0 2 2 2 0 Histidyl-tRNA synthetase FAM184 PF15665.5 EGD94785.1 - 0.044 13.6 3.0 0.091 12.5 3.0 1.4 1 0 0 1 1 1 0 Family with sequence similarity 184, A and B Flagellar_rod PF05149.12 EGD94785.1 - 0.055 12.9 3.0 0.08 12.4 3.0 1.2 1 0 0 1 1 1 0 Paraflagellar rod protein Spc7 PF08317.11 EGD94785.1 - 0.062 12.2 4.8 0.11 11.4 4.8 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein Nebulin PF00880.18 EGD94785.1 - 0.14 12.1 0.1 1.5 8.8 0.0 2.3 2 0 0 2 2 2 0 Nebulin repeat FUSC PF04632.12 EGD94785.1 - 0.2 10.2 0.5 0.28 9.7 0.5 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family BLOC1_2 PF10046.9 EGD94785.1 - 0.38 11.1 1.9 7.6 6.9 0.0 2.2 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 OmpH PF03938.14 EGD94785.1 - 1.2 9.5 7.9 2.3 8.6 7.9 1.4 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) KELK PF15796.5 EGD94785.1 - 1.3 9.5 8.3 1.9 9.0 7.2 1.8 1 1 1 2 2 2 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase JIP_LZII PF16471.5 EGD94785.1 - 1.8 8.8 4.8 25 5.1 0.1 2.5 2 0 0 2 2 2 0 JNK-interacting protein leucine zipper II DUF2205 PF10224.9 EGD94785.1 - 1.9 8.6 8.6 8.1 6.5 0.3 2.4 1 1 1 2 2 2 0 Short coiled-coil protein DivIC PF04977.15 EGD94785.1 - 8.9 6.2 7.4 5.3 6.9 0.4 2.4 1 1 0 2 2 2 0 Septum formation initiator APH PF01636.23 EGD94786.1 - 4.1e-08 33.4 0.0 3.8e-07 30.3 0.0 2.0 1 1 0 1 1 1 1 Phosphotransferase enzyme family Fructosamin_kin PF03881.14 EGD94786.1 - 4.1e-05 22.9 0.0 0.015 14.5 0.0 2.2 2 0 0 2 2 2 2 Fructosamine kinase DUF1679 PF07914.11 EGD94786.1 - 0.0012 17.8 0.0 0.0023 16.9 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1679) EcKinase PF02958.20 EGD94786.1 - 0.061 12.6 0.1 0.15 11.4 0.0 1.6 2 0 0 2 2 2 0 Ecdysteroid kinase Strep_SA_rep PF06696.11 EGD94786.1 - 0.062 13.3 1.4 0.32 11.0 0.3 2.2 2 0 0 2 2 2 0 Streptococcal surface antigen repeat ABC_membrane PF00664.23 EGD94788.1 - 8.1e-87 291.3 39.2 1e-44 153.2 19.9 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EGD94788.1 - 1.5e-68 229.6 0.1 6.8e-34 117.3 0.0 2.9 3 0 0 3 3 2 2 ABC transporter RsgA_GTPase PF03193.16 EGD94788.1 - 1.7e-09 37.8 0.0 0.00046 20.1 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase AAA_29 PF13555.6 EGD94788.1 - 2.3e-08 33.6 0.4 0.0032 17.2 0.4 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain SMC_N PF02463.19 EGD94788.1 - 1.6e-07 31.0 3.2 0.012 15.1 0.1 4.3 4 0 0 4 4 4 1 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 EGD94788.1 - 2.3e-07 31.4 0.1 0.016 15.6 0.0 2.7 2 0 0 2 2 2 2 AAA ATPase domain ABC_ATPase PF09818.9 EGD94788.1 - 9.9e-07 27.9 2.7 0.024 13.4 0.0 4.2 4 0 0 4 4 4 2 Predicted ATPase of the ABC class AAA_22 PF13401.6 EGD94788.1 - 1.9e-06 28.2 0.8 0.18 12.0 0.0 3.8 2 2 0 2 2 2 2 AAA domain AAA_5 PF07728.14 EGD94788.1 - 3.9e-05 23.7 0.0 0.03 14.3 0.0 3.2 3 0 0 3 3 3 1 AAA domain (dynein-related subfamily) AAA_25 PF13481.6 EGD94788.1 - 4.5e-05 23.1 0.0 0.37 10.3 0.1 2.5 2 0 0 2 2 2 2 AAA domain AAA_15 PF13175.6 EGD94788.1 - 6.6e-05 22.8 0.1 0.33 10.6 0.0 2.8 3 0 0 3 3 3 2 AAA ATPase domain AAA_21 PF13304.6 EGD94788.1 - 0.00011 22.1 1.8 0.65 9.8 0.3 3.9 3 1 0 4 4 4 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA PF00004.29 EGD94788.1 - 0.00017 22.0 1.0 0.45 10.9 0.0 3.9 3 1 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) MMR_HSR1 PF01926.23 EGD94788.1 - 0.00022 21.3 0.0 0.062 13.4 0.0 2.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_30 PF13604.6 EGD94788.1 - 0.00035 20.3 0.2 1 9.0 0.2 3.6 4 0 0 4 4 3 1 AAA domain AAA_7 PF12775.7 EGD94788.1 - 0.00083 18.9 0.1 0.29 10.6 0.0 2.4 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_23 PF13476.6 EGD94788.1 - 0.00087 19.8 4.0 0.4 11.1 0.0 2.9 3 0 0 3 3 3 2 AAA domain AAA_33 PF13671.6 EGD94788.1 - 0.0016 18.6 0.5 1.1 9.4 0.0 3.0 3 0 0 3 3 3 1 AAA domain RNA_helicase PF00910.22 EGD94788.1 - 0.004 17.5 0.1 0.23 11.9 0.0 2.6 2 0 0 2 2 2 1 RNA helicase AAA_18 PF13238.6 EGD94788.1 - 0.0057 17.2 0.2 5.2 7.6 0.0 3.0 3 0 0 3 3 3 1 AAA domain AAA_28 PF13521.6 EGD94788.1 - 0.0061 16.8 3.8 2.6 8.3 0.0 3.6 3 1 0 3 3 2 1 AAA domain G-alpha PF00503.20 EGD94788.1 - 0.015 14.5 0.0 5.4 6.1 0.0 2.3 2 0 0 2 2 2 0 G-protein alpha subunit Rad17 PF03215.15 EGD94788.1 - 0.015 15.2 0.0 0.17 11.8 0.0 2.4 2 0 0 2 2 2 0 Rad17 P-loop domain Zeta_toxin PF06414.12 EGD94788.1 - 0.034 13.4 0.0 3.6 6.8 0.0 2.8 3 0 0 3 3 2 0 Zeta toxin AAA_14 PF13173.6 EGD94788.1 - 0.064 13.3 0.0 3.7 7.6 0.0 3.1 3 0 0 3 3 3 0 AAA domain SRP54 PF00448.22 EGD94788.1 - 0.08 12.6 0.4 5.6 6.5 0.1 2.5 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain DUF87 PF01935.17 EGD94788.1 - 0.099 12.7 0.1 1.6 8.8 0.1 2.4 2 0 0 2 2 2 0 Helicase HerA, central domain APS_kinase PF01583.20 EGD94788.1 - 0.1 12.5 0.2 2.5 8.0 0.1 2.8 2 1 0 2 2 2 0 Adenylylsulphate kinase AAA_24 PF13479.6 EGD94788.1 - 0.14 11.9 0.0 21 4.8 0.0 2.4 2 0 0 2 2 2 0 AAA domain DUF3632 PF12311.8 EGD94789.1 - 1.7e-31 110.0 0.2 2.2e-31 109.6 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3632) AMP-binding PF00501.28 EGD94790.1 - 1.2e-27 96.6 0.2 1.8e-27 96.1 0.2 1.2 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EGD94790.1 - 0.056 14.4 0.1 0.13 13.2 0.1 1.7 1 1 0 1 1 1 0 AMP-binding enzyme C-terminal domain AMP-binding PF00501.28 EGD94791.1 - 1.8e-09 36.7 0.0 2.2e-09 36.4 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme MFS_1 PF07690.16 EGD94792.1 - 4.3e-29 101.6 38.2 4.3e-29 101.6 38.2 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily UNC-93 PF05978.16 EGD94792.1 - 0.096 12.4 5.0 0.33 10.7 4.6 1.9 1 1 0 1 1 1 0 Ion channel regulatory protein UNC-93 Gln-synt_C PF00120.24 EGD94793.1 - 5.8e-16 58.4 0.0 6e-13 48.5 0.0 2.1 2 0 0 2 2 2 2 Glutamine synthetase, catalytic domain Gln-synt_N PF03951.19 EGD94793.1 - 1.4e-12 47.1 0.0 2.3e-12 46.5 0.0 1.3 1 0 0 1 1 1 1 Glutamine synthetase, beta-Grasp domain Med1 PF10744.9 EGD94794.1 - 3.3e-133 444.8 0.0 3.2e-132 441.5 0.0 2.0 2 0 0 2 2 2 1 Mediator of RNA polymerase II transcription subunit 1 CPSF100_C PF13299.6 EGD94794.1 - 0.79 9.9 8.7 6.1 7.0 1.2 3.9 4 0 0 4 4 4 0 Cleavage and polyadenylation factor 2 C-terminal CRA_rpt PF07046.11 EGD94794.1 - 2.6 8.3 5.5 16 5.8 0.9 2.6 2 0 0 2 2 2 0 Cytoplasmic repetitive antigen (CRA) like repeat Ank_2 PF12796.7 EGD94795.1 - 2.3e-14 53.7 0.0 5.4e-05 23.7 0.0 3.6 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EGD94795.1 - 3.1e-12 46.7 0.1 0.0049 17.4 0.0 4.7 4 0 0 4 4 4 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 EGD94795.1 - 3.9e-10 39.8 1.1 0.026 14.9 0.0 5.2 6 0 0 6 6 6 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EGD94795.1 - 3e-09 36.4 0.4 9.5 7.2 0.0 7.0 7 0 0 7 7 7 2 Ankyrin repeat Ank PF00023.30 EGD94795.1 - 3.9e-09 36.6 0.0 0.14 12.6 0.0 5.1 5 0 0 5 5 5 4 Ankyrin repeat F-box-like PF12937.7 EGD94795.1 - 0.0099 15.8 0.2 0.03 14.2 0.2 1.9 1 0 0 1 1 1 1 F-box-like MACPF PF01823.19 EGD94796.1 - 4.3e-16 59.7 0.9 6.6e-16 59.0 0.9 1.3 1 0 0 1 1 1 1 MAC/Perforin domain Toxin_10 PF05431.11 EGD94796.1 - 0.035 13.6 0.7 0.078 12.4 0.7 1.5 1 0 0 1 1 1 0 Insecticidal Crystal Toxin, P42 DUF1344 PF07076.11 EGD94796.1 - 0.069 13.1 0.1 0.16 11.9 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1344) FecR PF04773.13 EGD94796.1 - 0.29 11.8 2.2 0.45 11.2 0.4 2.1 2 0 0 2 2 2 0 FecR protein CBM_19 PF03427.13 EGD94796.1 - 0.53 10.3 3.9 1.5 8.9 3.9 1.7 1 0 0 1 1 1 0 Carbohydrate binding domain (family 19) SRAP PF02586.14 EGD94799.1 - 1.9e-63 214.0 0.1 1.4e-35 122.8 0.0 2.2 1 1 1 2 2 2 2 SOS response associated peptidase (SRAP) TPR_2 PF07719.17 EGD94800.1 - 0.00018 21.3 5.3 0.76 10.0 0.2 4.5 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.28 EGD94800.1 - 0.00026 20.7 4.5 0.15 11.9 0.1 4.3 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_12 PF13424.6 EGD94800.1 - 0.00037 20.7 12.9 0.26 11.6 0.1 5.4 5 2 0 5 5 5 2 Tetratricopeptide repeat TPR_8 PF13181.6 EGD94800.1 - 0.083 13.1 9.6 0.63 10.4 0.0 4.5 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_19 PF14559.6 EGD94800.1 - 0.1 13.1 0.6 0.1 13.1 0.6 3.7 4 1 1 5 5 5 0 Tetratricopeptide repeat Peptidase_M4 PF01447.18 EGD94800.1 - 0.18 12.3 0.1 0.34 11.4 0.1 1.4 1 0 0 1 1 1 0 Thermolysin metallopeptidase, catalytic domain TPR_7 PF13176.6 EGD94800.1 - 0.26 11.4 9.7 16 5.8 0.0 5.4 6 0 0 6 6 6 0 Tetratricopeptide repeat WD40 PF00400.32 EGD94801.1 - 2.4e-44 148.4 26.9 1.2e-09 38.7 0.2 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EGD94801.1 - 1.4e-09 38.1 0.6 0.06 13.7 0.0 4.4 2 1 3 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EGD94801.1 - 5.2e-05 22.1 8.5 0.1 11.3 0.1 4.7 1 1 4 6 6 6 3 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 EGD94801.1 - 0.0019 17.3 0.0 0.9 8.4 0.0 3.7 2 2 1 4 4 4 1 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 EGD94801.1 - 0.016 15.2 0.2 20 5.3 0.0 4.2 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 EGD94801.1 - 0.02 13.4 0.0 2.1 6.8 0.0 2.2 2 0 0 2 2 2 0 Cytochrome D1 heme domain WD40_like PF17005.5 EGD94801.1 - 0.035 13.5 0.0 1.9 7.7 0.0 2.2 2 0 0 2 2 2 0 WD40-like domain Sdh5 PF03937.16 EGD94802.1 - 2e-24 85.3 0.2 7e-24 83.6 0.2 1.9 2 0 0 2 2 2 1 Flavinator of succinate dehydrogenase EMP24_GP25L PF01105.24 EGD94803.1 - 4.4e-40 137.6 0.0 5.4e-40 137.3 0.0 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD EzrA PF06160.12 EGD94803.1 - 0.17 10.0 0.3 0.23 9.6 0.3 1.1 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA Dicty_REP PF05086.12 EGD94805.1 - 0.96 7.3 12.0 1.8 6.4 12.0 1.3 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DUF3439 PF11921.8 EGD94805.1 - 2.1 8.3 10.6 1.1 9.3 7.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) RRN3 PF05327.11 EGD94807.1 - 0.039 12.5 5.2 0.067 11.7 5.2 1.4 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 SDA1 PF05285.12 EGD94807.1 - 0.2 11.1 13.0 0.29 10.5 13.0 1.2 1 0 0 1 1 1 0 SDA1 DNA_pol_phi PF04931.13 EGD94807.1 - 0.35 8.9 22.8 0.51 8.4 22.8 1.2 1 0 0 1 1 1 0 DNA polymerase phi CobT PF06213.12 EGD94807.1 - 0.76 9.1 9.8 1.9 7.8 8.1 2.1 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT Nop14 PF04147.12 EGD94807.1 - 2.2 6.4 12.7 2.9 6.0 12.7 1.3 1 0 0 1 1 1 0 Nop14-like family UBN_AB PF14075.6 EGD94809.1 - 0.0032 17.2 1.0 0.004 16.9 1.0 1.2 1 0 0 1 1 1 1 Ubinuclein conserved middle domain NDUFA12 PF05071.16 EGD94811.1 - 2e-10 41.4 10.4 4.5e-09 37.0 10.4 2.4 1 1 0 1 1 1 1 NADH ubiquinone oxidoreductase subunit NDUFA12 PTRF_SDPR PF15237.6 EGD94811.1 - 0.069 12.8 0.2 0.096 12.3 0.2 1.1 1 0 0 1 1 1 0 PTRF/SDPR family CH PF00307.31 EGD94812.1 - 6.3e-14 52.1 0.0 1.1e-13 51.3 0.0 1.4 1 0 0 1 1 1 1 Calponin homology (CH) domain CDC24 PF06395.11 EGD94812.1 - 0.11 12.8 0.0 0.2 11.9 0.0 1.3 1 0 0 1 1 1 0 CDC24 Calponin Calponin PF00402.18 EGD94812.1 - 0.17 11.6 5.5 1.1 8.9 1.3 2.7 2 0 0 2 2 2 0 Calponin family repeat PGA2 PF07543.12 EGD94813.1 - 0.37 10.8 6.1 0.98 9.4 5.1 1.9 2 0 0 2 2 2 0 Protein trafficking PGA2 ORMDL PF04061.14 EGD94816.1 - 1.8e-58 196.2 3.4 2.1e-58 196.0 3.4 1.0 1 0 0 1 1 1 1 ORMDL family Pollen_Ole_e_I PF01190.17 EGD94818.1 - 0.11 12.8 2.6 0.28 11.6 2.6 1.6 1 0 0 1 1 1 0 Pollen proteins Ole e I like HAD_2 PF13419.6 EGD94819.1 - 6.1e-15 55.8 0.0 1.8e-14 54.2 0.0 1.7 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EGD94819.1 - 1.1e-13 52.0 0.0 8.8e-11 42.5 0.0 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EGD94819.1 - 1.2e-06 28.5 0.0 2.3e-06 27.5 0.0 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like HAD PF12710.7 EGD94819.1 - 0.0015 18.9 0.0 0.0061 17.0 0.0 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 EGD94819.1 - 0.022 14.9 0.1 0.2 11.8 0.1 2.2 1 1 0 1 1 1 0 Haloacid dehalogenase-like hydrolase APH PF01636.23 EGD94820.1 - 8.4e-12 45.5 0.0 2e-11 44.3 0.0 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EGD94820.1 - 0.028 14.0 0.0 0.047 13.3 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase DUF1679 PF07914.11 EGD94820.1 - 0.12 11.2 0.0 0.2 10.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1679) TRP PF06011.12 EGD94824.1 - 2.2e-110 369.4 22.0 1.5e-67 228.2 8.6 2.1 1 1 1 2 2 2 2 Transient receptor potential (TRP) ion channel TRP_N PF14558.6 EGD94824.1 - 1.5e-34 119.4 0.1 2.5e-34 118.6 0.1 1.4 1 0 0 1 1 1 1 ML-like domain DUF1883 PF08980.10 EGD94824.1 - 0.079 12.9 0.0 0.17 11.9 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1883) SLATT_fungal PF18142.1 EGD94824.1 - 7.6 6.5 6.3 1.6 8.7 2.5 1.9 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain zf-U1 PF06220.12 EGD94825.1 - 6e-06 25.9 0.8 8.3e-06 25.5 0.8 1.2 1 0 0 1 1 1 1 U1 zinc finger p450 PF00067.22 EGD94826.1 - 2.2e-58 198.1 0.0 2.8e-58 197.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 HsbA PF12296.8 EGD94827.1 - 2.3e-10 41.0 0.0 3.4e-10 40.4 0.0 1.3 1 0 0 1 1 1 1 Hydrophobic surface binding protein A DUF3602 PF12223.8 EGD94829.1 - 4.8e-19 68.7 4.3 7.7e-14 52.1 0.1 2.6 2 1 1 3 3 3 2 Protein of unknown function (DUF3602) GTP1_OBG PF01018.22 EGD94829.1 - 0.19 11.3 4.6 16 5.1 0.3 3.1 1 1 2 3 3 3 0 GTP1/OBG Actin PF00022.19 EGD94830.1 - 7.9e-84 281.6 0.0 3.3e-58 197.2 0.0 2.0 1 1 1 2 2 2 2 Actin Glyco_tran_28_C PF04101.16 EGD94831.1 - 2.3e-17 63.5 0.1 9.1e-17 61.5 0.1 1.8 1 1 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain MRP-S28 PF10213.9 EGD94832.1 - 2.8e-10 40.7 0.1 4.9e-10 39.9 0.1 1.4 1 0 0 1 1 1 1 Mitochondrial ribosomal subunit protein Glyco_hydro_3_C PF01915.22 EGD94836.1 - 2.4e-47 161.5 0.0 4e-47 160.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 EGD94836.1 - 2.4e-39 135.6 0.0 5.1e-39 134.5 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 EGD94836.1 - 3.3e-12 46.3 0.0 6.4e-12 45.4 0.0 1.5 1 0 0 1 1 1 1 Fibronectin type III-like domain Glyco_hydro_47 PF01532.20 EGD94837.1 - 2.8e-162 540.8 0.0 9.9e-88 295.0 0.0 2.0 1 1 1 2 2 2 2 Glycosyl hydrolase family 47 Glyco_hydro_127 PF07944.12 EGD94837.1 - 0.00064 18.3 0.0 0.042 12.3 0.0 2.4 2 1 0 2 2 2 2 Beta-L-arabinofuranosidase, GH127 DUF5615 PF18480.1 EGD94837.1 - 0.14 11.9 0.0 0.28 11.0 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5615) SKG6 PF08693.10 EGD94838.1 - 0.00025 20.4 0.1 0.00046 19.5 0.1 1.4 1 0 0 1 1 1 1 Transmembrane alpha-helix domain TMEM51 PF15345.6 EGD94838.1 - 0.015 15.1 0.1 0.021 14.7 0.1 1.2 1 0 0 1 1 1 0 Transmembrane protein 51 DUF4381 PF14316.6 EGD94838.1 - 0.09 13.0 0.0 0.16 12.2 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) Sensor PF13796.6 EGD94838.1 - 0.12 12.5 0.2 0.24 11.4 0.0 1.5 2 0 0 2 2 2 0 Putative sensor Mfa_like_2 PF15415.6 EGD94838.1 - 0.17 10.7 0.0 0.24 10.2 0.0 1.2 1 0 0 1 1 1 0 Fimbrillin-like Fungal_trans PF04082.18 EGD94839.1 - 1.4e-24 86.6 0.0 6.3e-24 84.4 0.0 2.1 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EGD94839.1 - 6.5e-09 35.8 10.8 1.2e-08 35.0 10.8 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SUIM_assoc PF16619.5 EGD94839.1 - 0.51 10.4 24.6 1.9 8.6 13.0 2.9 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Spt20 PF12090.8 EGD94839.1 - 1.4 8.5 34.9 0.06 12.9 14.6 2.4 2 0 0 2 2 2 0 Spt20 family DUF4407 PF14362.6 EGD94839.1 - 4.7 6.5 4.9 9.1 5.5 4.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) CcdA PF07362.12 EGD94839.1 - 5.3 7.6 5.6 12 6.4 5.6 1.5 1 0 0 1 1 1 0 Post-segregation antitoxin CcdA Man-6-P_recep PF02157.15 EGD94840.1 - 3.9e-12 45.8 0.0 2.4e-11 43.2 0.0 1.9 2 0 0 2 2 2 1 Mannose-6-phosphate receptor ATG27 PF09451.10 EGD94840.1 - 4.1e-09 36.7 0.1 5.9e-08 32.9 0.0 2.1 2 0 0 2 2 2 1 Autophagy-related protein 27 CIMR PF00878.18 EGD94840.1 - 1.4e-07 31.7 0.2 4.3e-05 23.6 0.0 2.4 2 0 0 2 2 2 2 Cation-independent mannose-6-phosphate receptor repeat Roughex PF06020.11 EGD94840.1 - 8.2 5.4 7.1 31 3.5 5.1 2.0 2 0 0 2 2 2 0 Drosophila roughex protein ERG4_ERG24 PF01222.17 EGD94841.1 - 3.5e-138 461.0 0.1 2.4e-137 458.3 0.1 1.8 1 1 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family DUF1295 PF06966.12 EGD94841.1 - 0.00023 20.8 0.4 0.00052 19.6 0.1 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF1295) A_deamin PF02137.18 EGD94842.1 - 6.1e-24 85.1 0.0 1.8e-21 77.0 0.0 2.5 1 1 0 2 2 2 2 Adenosine-deaminase (editase) domain APOBEC_N PF08210.11 EGD94842.1 - 0.0054 16.6 0.4 0.018 14.9 0.2 1.8 2 0 0 2 2 2 1 APOBEC-like N-terminal domain SF3b10 PF07189.11 EGD94844.1 - 7.2e-34 115.7 0.0 8.4e-34 115.5 0.0 1.0 1 0 0 1 1 1 1 Splicing factor 3B subunit 10 (SF3b10) p450 PF00067.22 EGD94847.1 - 7.4e-41 140.4 0.0 1.1e-37 129.9 0.0 2.1 1 1 1 2 2 2 2 Cytochrome P450 p450 PF00067.22 EGD94848.1 - 8.9e-30 103.8 0.0 1.4e-29 103.2 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 NT-C2 PF10358.9 EGD94849.1 - 2.7e-12 46.6 0.0 3.9e-12 46.1 0.0 1.2 1 0 0 1 1 1 1 N-terminal C2 in EEIG1 and EHBP1 proteins SLS PF14611.6 EGD94850.1 - 3.9e-34 118.4 0.0 7.1e-34 117.6 0.0 1.5 1 0 0 1 1 1 1 Mitochondrial inner-membrane-bound regulator EcoEI_R_C PF08463.10 EGD94850.1 - 0.0015 18.7 0.3 0.0031 17.7 0.3 1.5 1 0 0 1 1 1 1 EcoEI R protein C-terminal Myotub-related PF06602.14 EGD94851.1 - 5.7e-150 499.1 0.0 6.9e-150 498.9 0.0 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain Y_phosphatase3 PF13350.6 EGD94851.1 - 0.0012 18.9 0.2 0.0038 17.2 0.0 1.8 2 0 0 2 2 2 1 Tyrosine phosphatase family Y_phosphatase PF00102.27 EGD94851.1 - 0.07 12.7 0.0 0.12 11.9 0.0 1.2 1 0 0 1 1 1 0 Protein-tyrosine phosphatase Ribosomal_S3_C PF00189.20 EGD94852.1 - 3.7e-25 88.3 0.1 2e-24 85.9 0.1 2.1 2 0 0 2 2 2 1 Ribosomal protein S3, C-terminal domain KH_2 PF07650.17 EGD94852.1 - 6.5e-12 45.1 0.1 1.2e-11 44.3 0.1 1.5 1 0 0 1 1 1 1 KH domain Coilin_N PF15862.5 EGD94852.1 - 0.036 13.9 0.1 0.34 10.7 0.0 2.0 2 0 0 2 2 2 0 Coilin N-terminus UN_NPL4 PF11543.8 EGD94852.1 - 0.1 13.1 0.0 0.2 12.1 0.0 1.5 1 0 0 1 1 1 0 Nuclear pore localisation protein NPL4 tRNA_synthFbeta PF17759.1 EGD94853.1 - 8.6e-50 169.1 0.0 1.2e-49 168.6 0.0 1.2 1 0 0 1 1 1 1 Phenylalanyl tRNA synthetase beta chain CLM domain PhetRS_B1 PF18262.1 EGD94853.1 - 4.1e-27 94.2 0.2 4.8e-26 90.8 0.0 2.2 2 0 0 2 2 2 1 Phe-tRNA synthetase beta subunit B1 domain B3_4 PF03483.17 EGD94853.1 - 1.1e-24 87.1 0.1 2.1e-24 86.2 0.1 1.5 1 0 0 1 1 1 1 B3/4 domain B5 PF03484.15 EGD94853.1 - 2.8e-18 66.0 0.0 9.5e-15 54.7 0.0 2.5 2 0 0 2 2 2 2 tRNA synthetase B5 domain DUF2740 PF10872.8 EGD94853.1 - 0.063 13.2 0.0 0.14 12.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2740) HEAT PF02985.22 EGD94854.1 - 4.3e-39 129.2 13.0 0.015 15.5 0.1 11.9 12 0 0 12 12 12 10 HEAT repeat HEAT_2 PF13646.6 EGD94854.1 - 3.6e-34 117.0 4.2 9.3e-10 38.8 0.0 7.3 3 2 3 7 7 7 7 HEAT repeats HEAT_EZ PF13513.6 EGD94854.1 - 2.4e-13 50.3 5.8 5.9e-05 23.5 0.0 7.9 7 2 2 9 9 9 2 HEAT-like repeat Cnd1 PF12717.7 EGD94854.1 - 3.6e-11 43.4 8.2 0.0022 18.0 0.3 5.4 5 1 1 6 6 6 2 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 EGD94854.1 - 2.9e-10 40.6 2.7 0.00025 21.6 0.1 6.4 5 2 4 9 9 9 1 Vacuolar 14 Fab1-binding region Adaptin_N PF01602.20 EGD94854.1 - 3.1e-08 32.7 6.4 3.2e-07 29.3 1.3 3.5 2 1 2 4 4 4 1 Adaptin N terminal region RTP1_C1 PF10363.9 EGD94854.1 - 1.6e-05 25.1 6.2 0.98 9.6 0.4 4.9 4 1 0 4 4 4 2 Required for nuclear transport of RNA pol II C-terminus 1 CLASP_N PF12348.8 EGD94854.1 - 0.0087 15.6 3.0 3.5 7.1 0.1 4.4 4 2 2 6 6 6 1 CLASP N terminal Proteasom_PSMB PF10508.9 EGD94854.1 - 0.011 14.3 4.3 0.65 8.4 1.5 2.4 2 1 0 2 2 2 0 Proteasome non-ATPase 26S subunit Arm PF00514.23 EGD94854.1 - 0.11 12.6 4.6 2.9 8.1 0.0 4.7 6 0 0 6 6 6 0 Armadillo/beta-catenin-like repeat M11L PF11099.8 EGD94854.1 - 0.17 12.2 0.2 57 4.0 0.1 3.3 2 1 1 3 3 3 0 Apoptosis regulator M11L like Ecm29 PF13001.7 EGD94854.1 - 0.42 9.2 3.2 14 4.2 0.1 3.5 3 1 1 4 4 4 0 Proteasome stabiliser API5 PF05918.11 EGD94854.1 - 2.8 6.6 6.3 1.1 7.9 1.6 2.7 3 1 0 3 3 3 0 Apoptosis inhibitory protein 5 (API5) Glyco_transf_8 PF01501.20 EGD94855.1 - 1.1e-25 90.7 0.0 2.3e-25 89.7 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 8 DUF3072 PF11272.8 EGD94855.1 - 0.054 13.4 0.4 0.14 12.1 0.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3072) Abhydrolase_6 PF12697.7 EGD94856.1 - 9.6e-15 55.8 0.8 1.5e-13 51.9 0.8 2.2 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EGD94856.1 - 4.9e-12 46.0 0.0 2.9e-11 43.5 0.0 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EGD94856.1 - 0.00085 18.7 0.0 0.0015 17.9 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 EHN PF06441.12 EGD94856.1 - 0.021 15.2 0.1 0.042 14.2 0.1 1.5 1 0 0 1 1 1 0 Epoxide hydrolase N terminus Abhydrolase_2 PF02230.16 EGD94856.1 - 0.1 12.4 0.0 14 5.4 0.0 2.2 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase Med10 PF09748.9 EGD94856.1 - 0.12 12.4 0.0 0.21 11.6 0.0 1.4 1 0 0 1 1 1 0 Transcription factor subunit Med10 of Mediator complex Glyco_transf_90 PF05686.12 EGD94857.1 - 8e-16 57.9 10.4 1.6e-12 47.0 8.0 3.2 2 1 0 2 2 2 2 Glycosyl transferase family 90 Tau95_N PF17682.1 EGD94857.1 - 0.17 12.1 0.0 0.34 11.1 0.0 1.5 1 0 0 1 1 1 0 Tau95 Triple barrel domain CDO_I PF05995.12 EGD94858.1 - 2.7e-40 137.4 0.0 3.3e-40 137.2 0.0 1.1 1 0 0 1 1 1 1 Cysteine dioxygenase type I PCO_ADO PF07847.12 EGD94858.1 - 8e-07 28.7 0.0 1.1e-06 28.2 0.0 1.3 1 0 0 1 1 1 1 PCO_ADO MMR_HSR1_Xtn PF16897.5 EGD94859.1 - 2e-39 133.9 0.8 5e-39 132.6 0.3 1.8 2 0 0 2 2 2 1 C-terminal region of MMR_HSR1 domain TGS PF02824.21 EGD94859.1 - 1.9e-22 79.0 0.0 4e-22 78.0 0.0 1.6 1 0 0 1 1 1 1 TGS domain MMR_HSR1 PF01926.23 EGD94859.1 - 1.2e-20 73.7 0.1 3.7e-20 72.1 0.0 1.8 1 1 1 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EGD94859.1 - 3.8e-09 36.3 0.1 1.7e-08 34.2 0.0 1.9 2 0 0 2 2 2 1 Ferrous iron transport protein B Dynamin_N PF00350.23 EGD94859.1 - 0.00091 19.3 0.1 0.2 11.7 0.0 2.3 2 0 0 2 2 2 2 Dynamin family MeaB PF03308.16 EGD94859.1 - 0.0062 15.6 0.1 0.018 14.0 0.1 1.7 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB Arf PF00025.21 EGD94859.1 - 0.14 11.6 0.3 7.5 6.0 0.0 2.2 2 0 0 2 2 2 0 ADP-ribosylation factor family RsgA_GTPase PF03193.16 EGD94859.1 - 0.15 12.0 1.0 3.7 7.4 0.1 2.7 2 1 1 3 3 3 0 RsgA GTPase DUF3289 PF11692.8 EGD94860.1 - 0.021 14.4 0.0 0.028 14.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3289) PXA PF02194.15 EGD94861.1 - 7.1e-45 153.2 0.0 2.1e-44 151.7 0.0 1.8 2 0 0 2 2 2 1 PXA domain IU_nuc_hydro PF01156.19 EGD94862.1 - 2.5e-81 273.6 0.0 2.9e-81 273.4 0.0 1.0 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase MR_MLE_C PF13378.6 EGD94863.1 - 7.1e-54 182.7 0.0 9.2e-54 182.3 0.0 1.1 1 0 0 1 1 1 1 Enolase C-terminal domain-like MR_MLE_N PF02746.16 EGD94863.1 - 1.2e-17 64.2 0.0 2.8e-17 63.0 0.0 1.6 1 0 0 1 1 1 1 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain Vac_ImportDeg PF09783.9 EGD94864.1 - 1.8e-39 135.2 0.4 4.5e-39 133.9 0.2 1.8 2 0 0 2 2 2 1 Vacuolar import and degradation protein Ribosomal_L7Ae PF01248.26 EGD94865.1 - 1.4e-26 92.0 0.6 1.9e-26 91.6 0.6 1.2 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family PELOTA_1 PF15608.6 EGD94865.1 - 0.11 12.4 0.0 0.17 11.8 0.0 1.3 1 0 0 1 1 1 0 PELOTA RNA binding domain Ank_2 PF12796.7 EGD94866.1 - 2.6e-24 85.6 0.2 1.2e-12 48.2 0.0 3.2 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EGD94866.1 - 2.4e-20 72.3 0.8 1.7e-09 37.8 0.0 4.5 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 EGD94866.1 - 1.9e-14 53.8 0.0 3.1e-07 30.8 0.0 3.3 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 EGD94866.1 - 1.5e-13 50.5 0.8 0.0011 19.3 0.0 4.6 4 0 0 4 4 4 3 Ankyrin repeat Ank_3 PF13606.6 EGD94866.1 - 7.1e-12 44.4 0.7 0.00015 21.9 0.0 4.2 5 0 0 5 5 5 3 Ankyrin repeat Steroid_dh PF02544.16 EGD94867.1 - 1.4e-09 38.1 1.3 1.4e-09 38.1 1.3 2.3 1 1 0 2 2 2 1 3-oxo-5-alpha-steroid 4-dehydrogenase SLATT_fungal PF18142.1 EGD94867.1 - 0.45 10.5 2.3 1.2 9.1 0.1 2.2 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain 2OG-FeII_Oxy_2 PF13532.6 EGD94868.1 - 5.6e-12 46.3 0.0 2.2e-11 44.3 0.0 1.8 1 1 1 2 2 2 1 2OG-Fe(II) oxygenase superfamily Rax2 PF12768.7 EGD94870.1 - 0.043 13.3 0.0 0.065 12.7 0.0 1.4 1 0 0 1 1 1 0 Cortical protein marker for cell polarity SKG6 PF08693.10 EGD94870.1 - 0.16 11.4 1.5 0.44 10.0 1.5 1.8 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Rotamase_3 PF13616.6 EGD94871.1 - 5.4e-16 59.2 0.1 1.1e-15 58.2 0.1 1.5 1 1 0 1 1 1 1 PPIC-type PPIASE domain Rotamase PF00639.21 EGD94871.1 - 2.8e-14 53.9 0.0 4.9e-14 53.1 0.0 1.4 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_2 PF13145.6 EGD94871.1 - 2.6e-05 25.0 0.1 4.1e-05 24.4 0.0 1.3 1 1 0 1 1 1 1 PPIC-type PPIASE domain UAA PF08449.11 EGD94872.1 - 4.9e-43 147.5 15.1 1.3e-42 146.1 15.1 1.6 1 1 0 1 1 1 1 UAA transporter family Nuc_sug_transp PF04142.15 EGD94872.1 - 1.9e-07 30.6 0.2 0.00086 18.6 0.0 2.2 2 0 0 2 2 2 2 Nucleotide-sugar transporter EamA PF00892.20 EGD94872.1 - 5e-05 23.5 34.4 0.0011 19.1 12.3 3.8 3 1 0 3 3 3 2 EamA-like transporter family Sen15 PF09631.10 EGD94873.1 - 9.1e-09 35.5 0.0 2.7e-08 34.0 0.0 1.8 1 1 0 1 1 1 1 Sen15 protein 4HBT_3 PF13622.6 EGD94873.1 - 0.082 13.1 0.0 0.11 12.8 0.0 1.3 1 0 0 1 1 1 0 Thioesterase-like superfamily VASt PF16016.5 EGD94874.1 - 8.6e-37 126.9 0.6 2e-36 125.7 0.2 1.9 2 0 0 2 2 2 1 VAD1 Analog of StAR-related lipid transfer domain BAR_3 PF16746.5 EGD94874.1 - 1.7e-15 57.4 0.2 2.8e-15 56.7 0.2 1.3 1 0 0 1 1 1 1 BAR domain of APPL family PH PF00169.29 EGD94874.1 - 1e-07 32.4 0.0 3.9e-07 30.5 0.0 2.1 2 0 0 2 2 2 1 PH domain GRAM PF02893.20 EGD94874.1 - 0.00085 19.2 0.0 0.0019 18.0 0.0 1.6 1 0 0 1 1 1 1 GRAM domain BAR PF03114.18 EGD94874.1 - 0.0064 16.2 1.2 0.011 15.4 1.2 1.3 1 0 0 1 1 1 1 BAR domain Kri1 PF05178.12 EGD94875.1 - 2.4e-30 105.1 20.5 2.4e-30 105.1 20.5 5.4 6 1 0 6 6 6 1 KRI1-like family Kri1_C PF12936.7 EGD94875.1 - 2.8e-29 101.1 0.2 2.8e-29 101.1 0.2 4.2 3 2 2 5 5 5 1 KRI1-like family C-terminal Mito_carr PF00153.27 EGD94876.1 - 1e-67 224.1 5.8 6.7e-25 86.8 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Stb3 PF10330.9 EGD94878.1 - 1.6e-37 127.4 0.0 2.7e-37 126.7 0.0 1.3 1 0 0 1 1 1 1 Putative Sin3 binding protein APH PF01636.23 EGD94880.1 - 4.5e-16 59.5 0.0 2.6e-15 57.0 0.0 2.2 1 1 0 1 1 1 1 Phosphotransferase enzyme family XkdW PF09636.10 EGD94880.1 - 0.029 14.5 0.0 0.35 11.0 0.0 2.4 2 0 0 2 2 2 0 XkdW protein RIO1 PF01163.22 EGD94880.1 - 0.051 13.2 0.1 0.15 11.7 0.0 1.7 2 0 0 2 2 2 0 RIO1 family PTS_2-RNA PF01885.16 EGD94881.1 - 1.7e-63 213.9 0.0 2.1e-63 213.7 0.0 1.1 1 0 0 1 1 1 1 RNA 2'-phosphotransferase, Tpt1 / KptA family zinc_ribbon_16 PF17034.5 EGD94882.1 - 4.9e-25 88.1 11.1 1e-24 87.1 11.1 1.6 1 0 0 1 1 1 1 Zinc-ribbon like family Zn_ribbon_17 PF17120.5 EGD94882.1 - 9.5e-06 25.2 7.3 9.5e-06 25.2 7.3 2.3 2 0 0 2 2 2 1 Zinc-ribbon, C4HC2 type zf-rbx1 PF12678.7 EGD94882.1 - 0.34 11.2 10.6 0.034 14.4 5.2 2.2 2 1 0 2 2 2 0 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 EGD94882.1 - 3.5 7.6 8.1 0.24 11.3 0.9 2.8 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) Efg1 PF10153.9 EGD94883.1 - 1.1e-31 109.5 12.6 1.1e-31 109.5 12.6 2.2 2 0 0 2 2 2 1 rRNA-processing protein Efg1 DUF573 PF04504.14 EGD94883.1 - 0.023 15.4 2.8 0.023 15.4 2.8 3.1 2 1 2 4 4 4 0 Protein of unknown function, DUF573 DUF1676 PF07898.13 EGD94883.1 - 5.3 7.1 7.2 13 5.8 7.2 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1676) LRR_6 PF13516.6 EGD94884.1 - 3e-13 48.7 12.8 0.0032 17.4 0.1 7.3 7 0 0 7 7 7 5 Leucine Rich repeat F-box-like PF12937.7 EGD94884.1 - 8.4e-11 41.6 0.1 2.4e-10 40.1 0.1 1.9 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EGD94884.1 - 8.7e-10 38.2 0.4 2.3e-09 36.9 0.4 1.8 1 0 0 1 1 1 1 F-box domain LRR_4 PF12799.7 EGD94884.1 - 2.5e-05 24.5 22.4 0.00014 22.2 1.2 5.4 4 2 1 6 6 6 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EGD94884.1 - 0.002 18.4 19.7 0.46 11.2 0.4 7.1 8 0 0 8 8 8 2 Leucine Rich Repeat PRANC PF09372.10 EGD94884.1 - 0.1 12.9 0.0 0.25 11.7 0.0 1.6 1 0 0 1 1 1 0 PRANC domain LRR_8 PF13855.6 EGD94884.1 - 0.13 12.1 4.1 13 5.6 0.1 4.1 4 1 0 4 4 4 0 Leucine rich repeat Pkinase PF00069.25 EGD94885.1 - 4.8e-55 186.8 0.0 7.1e-55 186.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD94885.1 - 9.9e-20 70.9 0.0 1.7e-19 70.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EGD94885.1 - 0.00013 21.5 0.0 0.00026 20.4 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 EGD94885.1 - 0.00016 20.7 0.0 0.00016 20.7 0.0 1.5 2 0 0 2 2 2 1 Haspin like kinase domain APH PF01636.23 EGD94885.1 - 0.0005 20.1 0.1 0.002 18.1 0.1 1.9 1 1 1 2 2 2 1 Phosphotransferase enzyme family PAS_9 PF13426.7 EGD94885.1 - 0.0042 17.3 0.0 6.9 7.0 0.0 2.9 2 0 0 2 2 2 2 PAS domain Pkinase_fungal PF17667.1 EGD94885.1 - 0.0071 15.2 0.0 0.014 14.2 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase RIO1 PF01163.22 EGD94885.1 - 0.0074 15.9 0.3 0.017 14.8 0.3 1.6 1 1 0 1 1 1 1 RIO1 family Choline_kinase PF01633.20 EGD94885.1 - 0.08 12.5 0.0 0.14 11.8 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase RabGAP-TBC PF00566.18 EGD94886.1 - 5.9e-32 111.1 1.2 1.7e-31 109.6 1.2 1.8 1 1 0 1 1 1 1 Rab-GTPase-TBC domain RAP1 PF07218.11 EGD94886.1 - 5.9 5.0 8.3 8.2 4.6 8.3 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) DUF5102 PF17104.5 EGD94887.1 - 0.65 10.0 6.7 0.97 9.4 0.4 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF5102) Yippee-Mis18 PF03226.14 EGD94889.1 - 2.6e-18 66.1 0.4 3e-18 66.0 0.4 1.1 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly RIG-I_C-RD PF11648.8 EGD94889.1 - 0.0015 18.7 2.4 0.0021 18.3 2.4 1.3 1 0 0 1 1 1 1 C-terminal domain of RIG-I DUF2039 PF10217.9 EGD94889.1 - 0.0083 16.4 1.8 0.064 13.6 0.2 2.1 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2039) DUF4451 PF14616.6 EGD94889.1 - 0.0084 16.3 2.5 0.013 15.7 2.5 1.3 1 1 0 1 1 1 1 Domain of unknown function (DUF4451) HNH_5 PF14279.6 EGD94889.1 - 0.031 14.1 1.1 0.18 11.7 0.1 2.1 2 0 0 2 2 2 0 HNH endonuclease Endonuclease_7 PF02945.15 EGD94889.1 - 0.038 13.9 2.3 0.077 12.9 2.3 1.7 1 1 0 1 1 1 0 Recombination endonuclease VII Eapp_C PF10238.9 EGD94889.1 - 0.16 12.0 3.5 0.9 9.6 3.5 2.0 1 1 0 1 1 1 0 E2F-associated phosphoprotein Evr1_Alr PF04777.13 EGD94889.1 - 0.35 11.4 2.7 1.8 9.0 0.4 2.1 1 1 1 2 2 2 0 Erv1 / Alr family ADH_N PF08240.12 EGD94890.1 - 2.9e-29 101.2 1.0 4.8e-29 100.4 1.0 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EGD94890.1 - 1.7e-17 63.6 0.0 2.5e-17 63.1 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 EGD94890.1 - 9.6e-06 25.2 0.0 2.1e-05 24.1 0.0 1.5 2 0 0 2 2 2 1 Glucose dehydrogenase C-terminus ADH_zinc_N_2 PF13602.6 EGD94890.1 - 0.0076 17.3 0.0 0.014 16.5 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N_assoc PF13823.6 EGD94890.1 - 0.026 14.4 0.4 0.095 12.7 0.4 2.1 1 0 0 1 1 1 0 Alcohol dehydrogenase GroES-associated AlaDh_PNT_C PF01262.21 EGD94890.1 - 0.041 13.2 0.0 0.07 12.4 0.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Dehydratase_hem PF13816.6 EGD94891.1 - 4.9e-115 384.2 0.0 5.7e-115 384.0 0.0 1.0 1 0 0 1 1 1 1 Haem-containing dehydratase DUF4188 PF13826.6 EGD94891.1 - 2e-08 34.6 0.1 0.0013 19.1 0.0 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF4188) KH_1 PF00013.29 EGD94892.1 - 4.4e-41 138.6 9.0 6.3e-17 61.2 0.1 3.2 3 0 0 3 3 3 3 KH domain KH_2 PF07650.17 EGD94892.1 - 4.1e-10 39.3 7.5 0.0012 18.6 0.2 3.4 3 0 0 3 3 3 3 KH domain KH_4 PF13083.6 EGD94892.1 - 2.8e-09 36.7 3.2 0.025 14.5 0.2 3.3 3 0 0 3 3 3 3 KH domain KH_5 PF13184.6 EGD94892.1 - 0.00091 19.3 6.8 0.29 11.3 0.1 3.4 3 0 0 3 3 3 2 NusA-like KH domain ECF-ribofla_trS PF07155.12 EGD94892.1 - 0.13 12.2 0.0 0.26 11.3 0.0 1.4 1 0 0 1 1 1 0 ECF-type riboflavin transporter, S component Epimerase PF01370.21 EGD94893.1 - 1.7e-15 57.2 0.0 2.6e-15 56.6 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EGD94893.1 - 3.6e-13 49.2 0.0 4.6e-13 48.8 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 EGD94893.1 - 7e-08 31.9 0.0 1.6e-07 30.8 0.0 1.5 1 1 0 1 1 1 1 Male sterility protein GDP_Man_Dehyd PF16363.5 EGD94893.1 - 7.8e-08 32.1 0.0 2e-07 30.7 0.0 1.6 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase KR PF08659.10 EGD94893.1 - 2.2e-06 27.7 0.0 3.4e-06 27.1 0.0 1.3 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 EGD94893.1 - 2.7e-06 27.4 0.0 5.5e-06 26.4 0.0 1.5 1 0 0 1 1 1 1 NAD(P)H-binding Polysacc_synt_2 PF02719.15 EGD94893.1 - 0.0018 17.5 0.0 0.0025 17.0 0.0 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein adh_short PF00106.25 EGD94893.1 - 0.019 14.4 0.1 0.038 13.5 0.0 1.5 2 0 0 2 2 2 0 short chain dehydrogenase NmrA PF05368.13 EGD94893.1 - 0.021 14.4 0.3 0.085 12.4 0.3 2.1 1 1 0 1 1 1 0 NmrA-like family RmlD_sub_bind PF04321.17 EGD94893.1 - 0.047 12.8 0.0 0.072 12.2 0.0 1.3 1 0 0 1 1 1 0 RmlD substrate binding domain DSBA PF01323.20 EGD94894.1 - 5.4e-36 124.2 0.0 6.1e-36 124.0 0.0 1.0 1 0 0 1 1 1 1 DSBA-like thioredoxin domain Thioredoxin_4 PF13462.6 EGD94894.1 - 0.011 16.0 0.1 0.059 13.5 0.0 2.0 2 0 0 2 2 2 0 Thioredoxin GRAS PF03514.14 EGD94894.1 - 0.18 10.7 0.0 0.24 10.3 0.0 1.1 1 0 0 1 1 1 0 GRAS domain family Pkinase PF00069.25 EGD94895.1 - 5e-25 88.4 0.0 1.7e-24 86.6 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD94895.1 - 1e-07 31.5 0.0 1.3e-06 27.9 0.0 2.3 2 1 0 2 2 2 1 Protein tyrosine kinase EABR PF12180.8 EGD94896.1 - 0.1 12.2 0.1 0.31 10.7 0.1 1.8 1 0 0 1 1 1 0 TSG101 and ALIX binding domain of CEP55 ABC2_membrane PF01061.24 EGD94897.1 - 1.4e-34 119.3 34.5 1.7e-30 106.0 6.9 4.5 4 1 0 5 5 5 3 ABC-2 type transporter ABC_tran PF00005.27 EGD94897.1 - 3.4e-21 76.2 0.1 8.6e-13 49.0 0.0 3.3 3 0 0 3 3 3 2 ABC transporter PDR_CDR PF06422.12 EGD94897.1 - 1.4e-13 50.5 8.3 2e-10 40.5 0.0 3.6 5 0 0 5 5 5 2 CDR ABC transporter ABC_trans_N PF14510.6 EGD94897.1 - 1.7e-05 25.3 0.2 5.6e-05 23.7 0.2 1.9 1 1 0 1 1 1 1 ABC-transporter N-terminal AAA_21 PF13304.6 EGD94897.1 - 0.00095 19.1 0.0 0.55 10.0 0.0 2.5 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system ABC2_membrane_3 PF12698.7 EGD94897.1 - 0.0016 17.7 9.8 0.0016 17.7 9.8 2.0 2 0 0 2 2 2 1 ABC-2 family transporter protein RsgA_GTPase PF03193.16 EGD94897.1 - 0.015 15.2 0.3 1.8 8.5 0.5 2.3 2 0 0 2 2 2 0 RsgA GTPase AAA_29 PF13555.6 EGD94897.1 - 0.02 14.6 0.2 0.55 10.0 0.0 2.7 3 0 0 3 3 3 0 P-loop containing region of AAA domain SMC_N PF02463.19 EGD94897.1 - 0.046 13.1 0.0 0.25 10.8 0.0 2.1 3 0 0 3 3 3 0 RecF/RecN/SMC N terminal domain AAA_33 PF13671.6 EGD94897.1 - 0.11 12.7 0.1 0.24 11.6 0.1 1.5 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 EGD94897.1 - 0.2 12.2 0.0 0.47 11.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain CDC45 PF02724.14 EGD94901.1 - 1.9 6.6 5.4 2.1 6.5 5.4 1.1 1 0 0 1 1 1 0 CDC45-like protein CENP-B_dimeris PF09026.10 EGD94901.1 - 4.6 7.7 14.0 0.96 9.9 9.7 1.9 2 0 0 2 2 2 0 Centromere protein B dimerisation domain FAM176 PF14851.6 EGD94901.1 - 5.4 6.7 6.0 2.9 7.6 3.1 1.9 2 0 0 2 2 2 0 FAM176 family DNA_pol_phi PF04931.13 EGD94901.1 - 8.3 4.4 8.1 12 3.8 8.1 1.1 1 0 0 1 1 1 0 DNA polymerase phi DSPc PF00782.20 EGD94904.1 - 1e-21 77.2 0.0 1.5e-21 76.6 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EGD94904.1 - 0.042 13.4 0.0 0.063 12.8 0.0 1.2 1 0 0 1 1 1 0 Protein-tyrosine phosphatase Beta-lactamase PF00144.24 EGD94905.1 - 1.3e-46 159.4 0.0 1.8e-46 158.9 0.0 1.1 1 0 0 1 1 1 1 Beta-lactamase DUF3471 PF11954.8 EGD94905.1 - 6.9e-08 32.9 0.1 1.3e-07 32.0 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3471) ABC_membrane PF00664.23 EGD94906.1 - 1.9e-100 336.0 38.7 2.1e-55 188.3 16.7 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EGD94906.1 - 2.5e-71 238.6 0.0 1.4e-34 119.5 0.0 2.6 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EGD94906.1 - 1.9e-16 60.2 6.3 2.9e-05 23.6 0.2 4.6 4 1 1 5 5 4 3 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 EGD94906.1 - 1.5e-10 41.7 4.3 0.001 19.5 1.6 3.7 3 1 0 3 3 2 2 AAA ATPase domain AAA_15 PF13175.6 EGD94906.1 - 1.3e-08 35.0 0.1 0.0011 18.8 0.0 2.2 2 0 0 2 2 2 2 AAA ATPase domain ABC_ATPase PF09818.9 EGD94906.1 - 1.6e-07 30.5 0.5 0.0061 15.4 0.0 2.4 2 0 0 2 2 2 2 Predicted ATPase of the ABC class RsgA_GTPase PF03193.16 EGD94906.1 - 1.7e-07 31.3 0.0 0.0061 16.5 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase AAA_29 PF13555.6 EGD94906.1 - 5.1e-07 29.3 0.2 0.025 14.3 0.0 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_21 PF13304.6 EGD94906.1 - 2.3e-06 27.6 0.3 0.0043 16.9 0.0 3.2 3 0 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 EGD94906.1 - 3.4e-06 27.4 0.4 0.012 15.9 0.1 3.5 2 2 0 2 2 2 1 AAA domain Zeta_toxin PF06414.12 EGD94906.1 - 5.2e-06 25.9 0.1 0.12 11.7 0.0 3.4 3 0 0 3 3 3 2 Zeta toxin AAA_30 PF13604.6 EGD94906.1 - 3.1e-05 23.8 0.5 0.13 12.0 0.0 3.8 4 0 0 4 4 4 1 AAA domain AAA_5 PF07728.14 EGD94906.1 - 0.00011 22.2 0.2 0.4 10.7 0.0 3.9 4 0 0 4 4 4 1 AAA domain (dynein-related subfamily) AAA PF00004.29 EGD94906.1 - 0.00014 22.3 0.9 16 5.9 0.2 4.3 3 1 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) G-alpha PF00503.20 EGD94906.1 - 0.00042 19.6 0.0 0.24 10.5 0.0 2.4 2 0 0 2 2 2 2 G-protein alpha subunit AAA_7 PF12775.7 EGD94906.1 - 0.0021 17.6 0.0 2.4 7.6 0.0 2.4 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA_23 PF13476.6 EGD94906.1 - 0.0021 18.6 0.0 3.8 8.0 0.0 2.5 2 0 0 2 2 2 2 AAA domain SbcCD_C PF13558.6 EGD94906.1 - 0.0027 17.9 3.2 3 8.2 0.1 3.7 2 2 0 2 2 2 2 Putative exonuclease SbcCD, C subunit PRK PF00485.18 EGD94906.1 - 0.003 17.3 0.0 0.47 10.2 0.0 2.3 2 0 0 2 2 2 1 Phosphoribulokinase / Uridine kinase family AAA_18 PF13238.6 EGD94906.1 - 0.0043 17.6 0.0 0.11 13.0 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EGD94906.1 - 0.0047 17.1 0.0 0.55 10.4 0.0 2.8 2 0 0 2 2 2 1 AAA domain DUF815 PF05673.13 EGD94906.1 - 0.0069 15.6 0.0 1.3 8.1 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF815) Rad17 PF03215.15 EGD94906.1 - 0.0092 15.9 0.1 1.5 8.7 0.0 3.1 3 0 0 3 3 3 1 Rad17 P-loop domain DUF87 PF01935.17 EGD94906.1 - 0.024 14.7 0.3 17 5.4 0.0 3.2 3 0 0 3 3 3 0 Helicase HerA, central domain AAA_24 PF13479.6 EGD94906.1 - 0.029 14.1 0.2 0.74 9.5 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 EGD94906.1 - 0.034 14.4 0.1 3.7 7.8 0.0 3.2 3 0 0 3 3 3 0 AAA domain AAA_25 PF13481.6 EGD94906.1 - 0.036 13.6 0.0 13 5.3 0.0 2.6 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 EGD94906.1 - 0.037 14.1 2.0 1.7 8.8 0.1 3.3 3 1 0 3 3 2 0 50S ribosome-binding GTPase RNA_helicase PF00910.22 EGD94906.1 - 0.057 13.8 0.1 8.2 6.9 0.0 3.0 2 0 0 2 2 2 0 RNA helicase Dynamin_N PF00350.23 EGD94906.1 - 0.065 13.3 1.6 36 4.4 0.0 4.5 5 0 0 5 5 5 0 Dynamin family APS_kinase PF01583.20 EGD94906.1 - 0.11 12.4 0.0 5 7.0 0.0 2.4 2 0 0 2 2 2 0 Adenylylsulphate kinase AMP-binding PF00501.28 EGD94907.1 - 1.2e-130 435.9 0.0 3.9e-65 220.1 0.0 2.2 2 0 0 2 2 2 2 AMP-binding enzyme Condensation PF00668.20 EGD94907.1 - 1.9e-109 366.4 0.0 1.3e-35 122.9 0.0 5.9 5 1 0 5 5 5 5 Condensation domain PP-binding PF00550.25 EGD94907.1 - 2.4e-35 120.7 0.2 1.9e-12 47.3 0.0 3.8 3 0 0 3 3 3 3 Phosphopantetheine attachment site AMP-binding_C PF13193.6 EGD94907.1 - 0.0014 19.5 0.0 0.19 12.7 0.0 2.8 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain HpaB PF03241.13 EGD94907.1 - 0.014 14.5 0.0 0.12 11.4 0.0 2.3 2 0 0 2 2 2 0 4-hydroxyphenylacetate 3-hydroxylase C terminal Cyclophil_like2 PF18050.1 EGD94907.1 - 0.018 15.0 0.0 1.2 9.1 0.0 2.6 2 0 0 2 2 2 0 Cyclophilin-like family Methyltransf_31 PF13847.6 EGD94908.1 - 7.4e-14 51.8 0.0 1.7e-13 50.7 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EGD94908.1 - 2.5e-07 31.3 0.0 3.2e-06 27.7 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EGD94908.1 - 9.1e-06 25.6 0.0 1.3e-05 25.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EGD94908.1 - 4.9e-05 23.9 0.0 0.00014 22.5 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EGD94908.1 - 0.0039 17.9 0.0 0.0087 16.8 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain MetW PF07021.12 EGD94908.1 - 0.026 14.1 0.1 0.047 13.3 0.1 1.4 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW MTS PF05175.14 EGD94908.1 - 0.13 11.8 0.0 0.21 11.1 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_16 PF10294.9 EGD94909.1 - 0.00054 19.7 0.0 0.084 12.6 0.0 2.2 1 1 0 2 2 2 2 Lysine methyltransferase zf-C2H2 PF00096.26 EGD94910.1 - 0.012 16.1 3.7 0.042 14.3 3.7 2.1 1 0 0 1 1 1 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EGD94910.1 - 0.57 11.2 3.3 2 9.5 3.3 2.0 1 0 0 1 1 1 0 C2H2-type zinc finger DUF1635 PF07795.11 EGD94910.1 - 7.6 6.3 7.9 3.9 7.3 0.1 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1635) ING PF12998.7 EGD94911.1 - 2.9e-07 31.0 0.0 6.8e-07 29.8 0.0 1.7 1 0 0 1 1 1 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.29 EGD94911.1 - 2.7e-06 27.2 9.6 6.2e-06 26.0 9.6 1.6 1 0 0 1 1 1 1 PHD-finger zf-HC5HC2H PF13771.6 EGD94911.1 - 0.15 12.3 1.0 0.34 11.2 1.0 1.6 1 0 0 1 1 1 0 PHD-like zinc-binding domain PHD_2 PF13831.6 EGD94911.1 - 1.3 8.6 3.6 2.2 7.9 3.6 1.3 1 0 0 1 1 1 0 PHD-finger Collagen PF01391.18 EGD94913.1 - 6.7e-07 29.0 9.6 1.7e-06 27.7 9.6 1.6 1 0 0 1 1 1 1 Collagen triple helix repeat (20 copies) BAG PF02179.16 EGD94914.1 - 5.3e-09 36.4 0.1 1.2e-08 35.2 0.1 1.6 1 0 0 1 1 1 1 BAG domain SUIM_assoc PF16619.5 EGD94914.1 - 0.0035 17.4 25.5 0.13 12.4 10.3 3.1 2 0 0 2 2 2 2 Unstructured region C-term to UIM in Ataxin3 CAP_N PF01213.19 EGD94914.1 - 0.0055 16.2 1.9 0.0055 16.2 1.9 4.2 2 1 1 4 4 4 1 Adenylate cyclase associated (CAP) N terminal XRCC4 PF06632.12 EGD94914.1 - 1.4 7.7 14.4 2.5 6.9 14.4 1.3 1 0 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 DUF4834 PF16118.5 EGD94914.1 - 1.6 9.8 9.9 10 7.2 0.6 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) LMBR1 PF04791.16 EGD94915.1 - 1.9e-123 413.1 1.8 2.1e-123 412.9 1.8 1.0 1 0 0 1 1 1 1 LMBR1-like membrane protein Ribosomal_60s PF00428.19 EGD94915.1 - 0.031 14.9 2.9 0.031 14.9 2.9 2.1 2 0 0 2 2 2 0 60s Acidic ribosomal protein Med15_fungi PF05397.12 EGD94916.1 - 2.5e-25 88.9 0.3 2.5e-25 88.9 0.3 7.7 8 1 0 8 8 8 1 Mediator complex subunit 15 EamA PF00892.20 EGD94917.1 - 1e-08 35.5 26.0 8.7e-06 26.0 2.9 2.7 2 1 0 2 2 2 2 EamA-like transporter family Nuc_sug_transp PF04142.15 EGD94917.1 - 1.1e-08 34.7 0.1 1.9e-08 33.9 0.1 1.4 1 0 0 1 1 1 1 Nucleotide-sugar transporter UAA PF08449.11 EGD94917.1 - 8.2e-05 21.9 8.0 0.00017 20.9 8.0 1.6 1 0 0 1 1 1 1 UAA transporter family TPT PF03151.16 EGD94917.1 - 0.00077 18.9 6.8 0.001 18.5 0.3 2.3 2 0 0 2 2 2 1 Triose-phosphate Transporter family DMT_6 PF04342.12 EGD94917.1 - 0.56 10.4 5.6 3.8 7.8 1.6 2.7 2 0 0 2 2 2 0 Putative member of DMT superfamily (DUF486) MBOAT PF03062.19 EGD94918.1 - 4.2e-35 121.7 22.5 6.4e-33 114.6 15.3 2.1 2 0 0 2 2 2 2 MBOAT, membrane-bound O-acyltransferase family Adaptin_N PF01602.20 EGD94919.1 - 6.4e-141 470.5 0.2 7.5e-141 470.2 0.2 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptinC2 PF02883.20 EGD94919.1 - 2.8e-21 75.9 0.0 7.2e-21 74.6 0.0 1.8 1 0 0 1 1 1 1 Adaptin C-terminal domain HEAT_2 PF13646.6 EGD94919.1 - 5.2e-09 36.4 0.5 0.0089 16.4 0.0 4.5 4 0 0 4 4 4 2 HEAT repeats Cnd1 PF12717.7 EGD94919.1 - 1.4e-08 35.0 2.5 0.00022 21.3 0.0 4.0 2 2 2 4 4 4 2 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 EGD94919.1 - 0.00047 20.2 2.1 6.5 7.3 0.1 4.4 4 0 0 4 4 4 1 HEAT repeat HEAT_EZ PF13513.6 EGD94919.1 - 0.0041 17.6 0.1 22 5.7 0.0 4.7 3 1 0 3 3 3 1 HEAT-like repeat Arm PF00514.23 EGD94919.1 - 0.038 14.0 0.1 99 3.2 0.1 5.1 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat RICTOR_M PF14666.6 EGD94919.1 - 0.063 13.1 0.5 0.43 10.4 0.0 2.5 2 0 0 2 2 2 0 Rapamycin-insensitive companion of mTOR, middle domain DnaJ PF00226.31 EGD94922.1 - 3.9e-21 75.0 1.0 8.6e-21 73.8 1.0 1.6 1 0 0 1 1 1 1 DnaJ domain PRP38_assoc PF12871.7 EGD94922.1 - 2.4e-05 24.8 34.8 2.4e-05 24.8 34.8 6.2 4 1 2 6 6 6 1 Pre-mRNA-splicing factor 38-associated hydrophilic C-term DDE_Tnp_IS1595 PF12762.7 EGD94924.1 - 0.046 13.7 1.8 0.069 13.1 1.8 1.3 1 0 0 1 1 1 0 ISXO2-like transposase domain DFRP_C PF16543.5 EGD94924.1 - 1.4 9.4 9.6 2.5 8.7 9.6 1.4 1 0 0 1 1 1 0 DRG Family Regulatory Proteins, Tma46 Peptidase_S49_N PF08496.10 EGD94924.1 - 6.1 6.9 8.8 9.1 6.3 8.8 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal AP3D1 PF06375.11 EGD94924.1 - 7.4 6.8 13.2 19 5.4 13.2 1.7 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 Pyr_redox_2 PF07992.14 EGD94926.1 - 2.8e-29 102.3 0.0 3.7e-29 101.9 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EGD94926.1 - 3.1e-11 43.7 0.0 5.3e-11 42.9 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EGD94926.1 - 1.4e-05 24.5 0.0 2.1e-05 24.0 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EGD94926.1 - 7.6e-05 22.0 0.2 0.00014 21.1 0.1 1.5 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) Trp_halogenase PF04820.14 EGD94926.1 - 0.00064 18.7 0.0 0.11 11.3 0.0 2.1 2 0 0 2 2 2 2 Tryptophan halogenase NAD_binding_9 PF13454.6 EGD94926.1 - 0.078 13.0 0.1 45 4.0 0.0 3.2 3 0 0 3 3 3 0 FAD-NAD(P)-binding Metallophos PF00149.28 EGD94927.1 - 4e-15 56.9 0.7 5.9e-15 56.3 0.7 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EGD94927.1 - 2e-07 31.3 0.1 9.5e-05 22.7 0.0 2.1 2 0 0 2 2 2 2 Calcineurin-like phosphoesterase superfamily domain Metallophos_3 PF14582.6 EGD94927.1 - 0.0056 16.0 0.0 0.9 8.8 0.0 2.5 2 1 0 2 2 2 2 Metallophosphoesterase, calcineurin superfamily MutL PF13941.6 EGD94927.1 - 0.026 13.1 0.0 0.038 12.6 0.0 1.1 1 0 0 1 1 1 0 MutL protein Ribosomal_L13 PF00572.18 EGD94928.1 - 3.6e-11 43.4 0.0 3.1e-09 37.1 0.0 2.3 1 1 0 1 1 1 1 Ribosomal protein L13 AMP-binding PF00501.28 EGD94929.1 - 2.1e-72 244.0 0.0 2.5e-72 243.8 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EGD94929.1 - 2.4e-16 60.5 0.1 5.5e-16 59.3 0.1 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain LysR_substrate PF03466.20 EGD94929.1 - 0.0035 16.7 0.0 0.007 15.7 0.0 1.5 1 0 0 1 1 1 1 LysR substrate binding domain LRR_6 PF13516.6 EGD94930.1 - 9.4e-13 47.1 22.4 0.35 11.0 0.0 12.6 13 0 0 13 13 13 3 Leucine Rich repeat F-box-like PF12937.7 EGD94930.1 - 2.5e-09 36.9 1.4 2.5e-09 36.9 1.4 3.1 3 0 0 3 3 3 1 F-box-like LRR_4 PF12799.7 EGD94930.1 - 5.1e-09 36.3 15.3 2.7 8.5 0.0 7.9 3 2 4 9 9 9 5 Leucine Rich repeats (2 copies) F-box PF00646.33 EGD94930.1 - 0.0016 18.2 8.9 0.0022 17.8 2.1 3.4 3 0 0 3 3 3 1 F-box domain Preseq_ALAS PF09029.10 EGD94930.1 - 0.055 13.9 0.3 0.23 12.0 0.1 2.1 2 1 1 3 3 3 0 5-aminolevulinate synthase presequence CbbQ_C PF08406.10 EGD94930.1 - 0.057 13.7 0.2 22 5.4 0.0 3.5 3 0 0 3 3 3 0 CbbQ/NirQ/NorQ C-terminal LRR_8 PF13855.6 EGD94930.1 - 0.41 10.4 10.2 3.6 7.4 0.0 5.3 5 1 1 6 6 6 0 Leucine rich repeat Peptidase_M28 PF04389.17 EGD94931.1 - 8.9e-35 120.2 0.0 1.5e-34 119.4 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M28 ATP-synt_8 PF00895.20 EGD94931.1 - 0.077 13.5 0.0 0.077 13.5 0.0 4.4 5 0 0 5 5 5 0 ATP synthase protein 8 Peptidase_M20 PF01546.28 EGD94931.1 - 0.12 12.1 0.0 0.2 11.3 0.0 1.3 1 0 0 1 1 1 0 Peptidase family M20/M25/M40 Med10 PF09748.9 EGD94933.1 - 7.8e-42 142.1 0.0 9.3e-42 141.8 0.0 1.1 1 0 0 1 1 1 1 Transcription factor subunit Med10 of Mediator complex DUF3877 PF12993.7 EGD94933.1 - 0.0089 15.9 0.0 0.014 15.3 0.0 1.4 1 1 0 1 1 1 1 Domain of unknown function, E. rectale Gene description (DUF3877) AAA_16 PF13191.6 EGD94935.1 - 9.2e-07 29.4 0.3 3.9e-06 27.3 0.3 2.1 2 1 0 2 2 2 1 AAA ATPase domain AAA PF00004.29 EGD94935.1 - 0.00023 21.6 0.0 0.029 14.8 0.0 2.6 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) ATPase_2 PF01637.18 EGD94935.1 - 0.0049 16.8 0.0 0.0095 15.9 0.0 1.5 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_7 PF12775.7 EGD94935.1 - 0.0086 15.6 0.0 0.016 14.8 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region DUF2859 PF11072.8 EGD94935.1 - 0.013 15.2 0.0 0.025 14.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2859) DUF815 PF05673.13 EGD94935.1 - 0.033 13.4 0.0 0.069 12.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_22 PF13401.6 EGD94935.1 - 0.048 13.9 0.3 0.48 10.7 0.2 2.4 2 1 0 2 2 2 0 AAA domain AAA_5 PF07728.14 EGD94935.1 - 0.08 12.9 0.0 0.29 11.1 0.0 1.9 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Metallophos PF00149.28 EGD94936.1 - 4.7e-12 46.8 0.4 8.9e-12 45.9 0.4 1.5 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EGD94936.1 - 6e-09 36.3 1.2 3e-08 34.0 1.2 1.9 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain CLU PF13236.6 EGD94938.1 - 3.1e-74 249.5 0.0 5.3e-74 248.8 0.0 1.4 1 0 0 1 1 1 1 Clustered mitochondria eIF3_p135 PF12807.7 EGD94938.1 - 1.5e-55 187.9 0.0 4.5e-55 186.4 0.0 1.9 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit 135 TPR_12 PF13424.6 EGD94938.1 - 5.5e-27 93.9 4.2 1.5e-12 47.6 0.0 3.9 3 1 1 4 4 4 3 Tetratricopeptide repeat CLU_N PF15044.6 EGD94938.1 - 1e-24 86.7 0.3 5.4e-24 84.4 0.1 2.3 2 0 0 2 2 2 1 Mitochondrial function, CLU-N-term TPR_10 PF13374.6 EGD94938.1 - 3.1e-22 77.7 0.6 1.3e-05 24.9 0.0 5.4 5 1 0 5 5 5 3 Tetratricopeptide repeat TPR_2 PF07719.17 EGD94938.1 - 9.5e-05 22.2 4.9 0.3 11.3 0.1 5.1 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_8 PF13181.6 EGD94938.1 - 0.0041 17.2 4.1 0.14 12.4 0.3 3.7 3 0 0 3 3 3 1 Tetratricopeptide repeat DUF727 PF05303.12 EGD94938.1 - 0.0049 16.9 0.0 0.017 15.2 0.0 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF727) TPR_17 PF13431.6 EGD94938.1 - 4.5 7.9 5.6 1.7e+02 3.0 0.1 4.9 5 0 0 5 5 5 0 Tetratricopeptide repeat Ferric_reduct PF01794.19 EGD94940.1 - 1.1e-21 77.2 9.5 1.1e-21 77.2 9.5 2.8 2 0 0 2 2 2 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.12 EGD94940.1 - 2.7e-17 63.3 0.0 8.7e-15 55.2 0.0 2.3 1 1 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 EGD94940.1 - 5.2e-13 49.0 0.0 3.9e-11 43.0 0.0 2.4 1 1 0 1 1 1 1 FAD-binding domain GST_N_3 PF13417.6 EGD94941.1 - 1.5e-15 57.4 0.0 2.4e-15 56.7 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 EGD94941.1 - 1.1e-14 54.5 0.0 1.9e-14 53.7 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EGD94941.1 - 5.9e-11 42.5 0.0 1.2e-10 41.6 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EGD94941.1 - 1.9e-10 40.8 0.0 3.4e-10 40.0 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EGD94941.1 - 4.5e-10 39.6 0.0 7.6e-10 38.9 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EGD94941.1 - 7.7e-08 32.3 0.0 1.5e-07 31.4 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Glyco_trans_1_2 PF13524.6 EGD94941.1 - 0.16 12.4 0.1 3.1 8.3 0.0 2.2 2 0 0 2 2 2 0 Glycosyl transferases group 1 SF1-HH PF16275.5 EGD94942.1 - 1.2e-43 148.0 1.0 3.1e-43 146.7 1.0 1.7 1 0 0 1 1 1 1 Splicing factor 1 helix-hairpin domain zf-CCHC PF00098.23 EGD94942.1 - 1.4e-11 43.9 11.1 2e-05 24.4 3.6 2.4 2 0 0 2 2 2 2 Zinc knuckle KH_1 PF00013.29 EGD94942.1 - 7.3e-07 28.9 0.0 1.4e-06 28.0 0.0 1.5 1 0 0 1 1 1 1 KH domain zf-CCHC_3 PF13917.6 EGD94942.1 - 2.5e-06 27.3 6.2 0.0014 18.6 2.9 2.6 1 1 1 2 2 2 2 Zinc knuckle zf-CCHC_4 PF14392.6 EGD94942.1 - 0.00052 19.7 4.7 0.28 11.0 0.4 2.4 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_6 PF15288.6 EGD94942.1 - 0.003 17.3 8.3 0.55 10.1 1.5 2.9 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_2 PF13696.6 EGD94942.1 - 0.022 14.6 0.6 0.022 14.6 0.6 2.4 2 0 0 2 2 2 0 Zinc knuckle Prim_Zn_Ribbon PF08273.12 EGD94942.1 - 4.6 7.6 7.4 0.75 10.1 3.0 1.9 2 0 0 2 2 2 0 Zinc-binding domain of primase-helicase DUF3716 PF12511.8 EGD94943.1 - 2.2e-06 27.6 0.7 4e-06 26.8 0.7 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF3716) C1_1 PF00130.22 EGD94943.1 - 0.068 13.1 0.1 0.091 12.7 0.1 1.2 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) HCO3_cotransp PF00955.21 EGD94944.1 - 1.8e-84 284.4 15.5 9.9e-45 153.3 6.9 2.0 1 1 1 2 2 2 2 HCO3- transporter family DEAD PF00270.29 EGD94945.1 - 9.6e-41 139.5 0.0 2.4e-40 138.1 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EGD94945.1 - 3e-30 104.8 0.0 6.5e-30 103.7 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EGD94945.1 - 0.00025 21.1 0.0 0.00052 20.0 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit SNF2_N PF00176.23 EGD94945.1 - 0.0094 14.7 0.0 0.018 13.8 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain tRNA-synt_1c PF00749.21 EGD94949.1 - 1.3e-100 336.3 0.0 1.8e-100 335.9 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.18 EGD94949.1 - 1.3e-20 74.0 0.0 2.2e-20 73.2 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain GST_C_3 PF14497.6 EGD94949.1 - 0.00078 19.6 0.1 0.037 14.2 0.0 2.6 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EGD94949.1 - 0.0064 16.7 0.0 0.015 15.5 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EGD94949.1 - 0.013 15.5 0.0 0.031 14.3 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain DUF1793 PF08760.11 EGD94950.1 - 4.7e-70 235.3 0.1 8.2e-70 234.6 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1793) DUF4965 PF16335.5 EGD94950.1 - 3.5e-53 179.8 0.3 9.8e-49 165.3 0.0 2.5 2 0 0 2 2 2 2 Domain of unknown function (DUF4965) DUF5127 PF17168.4 EGD94950.1 - 7.7e-22 78.2 0.0 1.7e-21 77.1 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF5127) DUF4964 PF16334.5 EGD94950.1 - 0.017 14.7 0.2 0.043 13.4 0.2 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4964) CusF_Ec PF11604.8 EGD94950.1 - 0.15 12.0 0.1 0.38 10.8 0.1 1.6 1 0 0 1 1 1 0 Copper binding periplasmic protein CusF Stm1_N PF09598.10 EGD94952.1 - 3.3e-14 53.5 5.2 3.3e-14 53.5 5.2 4.6 2 2 0 3 3 3 1 Stm1 HABP4_PAI-RBP1 PF04774.15 EGD94952.1 - 0.00023 22.0 13.0 0.00023 22.0 13.0 2.6 1 1 1 2 2 2 1 Hyaluronan / mRNA binding family bZIP_1 PF00170.21 EGD94953.1 - 9.1e-07 28.9 7.8 2.1e-06 27.7 7.8 1.6 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 EGD94953.1 - 0.0068 16.5 7.8 0.0068 16.5 7.8 2.1 2 0 0 2 2 2 1 Basic region leucine zipper GvpL_GvpF PF06386.11 EGD94953.1 - 0.13 12.2 1.5 0.25 11.2 1.5 1.4 1 0 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF CCDC-167 PF15188.6 EGD94953.1 - 0.54 10.6 3.9 1.1 9.6 3.9 1.4 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 167 Lgl_C PF08596.10 EGD94955.1 - 5.7e-121 403.9 0.0 4.6e-120 400.9 0.0 2.2 3 0 0 3 3 3 1 Lethal giant larvae(Lgl) like, C-terminal WD40 PF00400.32 EGD94955.1 - 0.015 16.1 3.3 14 6.8 0.1 5.4 6 0 0 6 6 6 0 WD domain, G-beta repeat APH PF01636.23 EGD94956.1 - 5.7e-05 23.2 0.0 8.4e-05 22.6 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family THUMP PF02926.17 EGD94957.1 - 2.2e-07 31.1 0.0 3.9e-07 30.3 0.0 1.5 1 0 0 1 1 1 1 THUMP domain TPP_enzyme_N PF02776.18 EGD94958.1 - 9.6e-32 110.0 0.0 1.5e-31 109.3 0.0 1.2 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.22 EGD94958.1 - 1.4e-20 73.5 0.0 2.9e-20 72.4 0.0 1.6 1 1 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.21 EGD94958.1 - 1.3e-14 54.2 0.0 3.3e-14 52.9 0.0 1.7 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain E1_dh PF00676.20 EGD94958.1 - 0.0053 15.8 0.0 0.0097 14.9 0.0 1.3 1 0 0 1 1 1 1 Dehydrogenase E1 component Bromodomain PF00439.25 EGD94959.1 - 1.1e-17 63.8 0.2 2.6e-17 62.6 0.2 1.6 1 0 0 1 1 1 1 Bromodomain Bromo_TP PF07524.13 EGD94959.1 - 1.7e-08 34.3 0.0 5.1e-08 32.8 0.0 1.8 1 0 0 1 1 1 1 Bromodomain associated NADH_Oxid_Nqo15 PF11497.8 EGD94959.1 - 0.085 12.9 0.0 0.18 11.8 0.0 1.5 1 0 0 1 1 1 0 NADH-quinone oxidoreductase chain 15 DUF3947 PF13135.6 EGD94959.1 - 4.1 7.7 7.1 8.9 6.6 7.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3947) VanZ PF04892.12 EGD94960.1 - 1.8e-07 31.8 1.1 2.5e-07 31.4 0.5 1.4 1 1 0 1 1 1 1 VanZ like family Phage_holin_2_4 PF16082.5 EGD94960.1 - 0.76 9.5 0.0 0.76 9.5 0.0 2.2 3 0 0 3 3 3 0 Bacteriophage holin family, superfamily II-like Y_phosphatase PF00102.27 EGD94961.1 - 8.5e-55 185.9 0.0 1.2e-54 185.4 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 EGD94961.1 - 0.001 19.2 0.0 0.0025 17.9 0.0 1.6 1 0 0 1 1 1 1 Inositol hexakisphosphate DSPc PF00782.20 EGD94961.1 - 0.0089 15.8 0.2 0.028 14.2 0.2 1.9 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 EGD94961.1 - 0.011 15.7 0.0 0.018 15.0 0.0 1.4 1 0 0 1 1 1 0 Tyrosine phosphatase family Ig_C19orf38 PF17737.1 EGD94961.1 - 0.07 13.5 0.1 0.26 11.7 0.0 1.9 2 0 0 2 2 2 0 Ig domain in C19orf38 (HIDE1) Piwi PF02171.17 EGD94962.1 - 1.1e-68 231.7 0.0 2.2e-68 230.7 0.0 1.5 1 0 0 1 1 1 1 Piwi domain ArgoN PF16486.5 EGD94962.1 - 3.6e-22 79.5 0.1 1e-21 78.0 0.1 1.8 1 0 0 1 1 1 1 N-terminal domain of argonaute PAZ PF02170.22 EGD94962.1 - 1.4e-13 50.8 0.6 2.7e-13 49.9 0.6 1.4 1 0 0 1 1 1 1 PAZ domain ArgoL1 PF08699.10 EGD94962.1 - 1.5e-11 43.8 1.1 3.9e-10 39.2 0.1 2.5 2 0 0 2 2 2 1 Argonaute linker 1 domain ArgoMid PF16487.5 EGD94962.1 - 2.6e-09 37.2 0.0 6.1e-09 36.0 0.0 1.5 1 0 0 1 1 1 1 Mid domain of argonaute ArgoL2 PF16488.5 EGD94962.1 - 3.2e-09 37.0 0.1 8.2e-09 35.7 0.1 1.8 1 0 0 1 1 1 1 Argonaute linker 2 domain PerB PF06590.11 EGD94962.1 - 0.15 12.6 0.0 0.46 11.0 0.0 1.8 1 0 0 1 1 1 0 PerB protein DUF3357 PF11837.8 EGD94964.1 - 0.14 12.7 0.1 0.18 12.2 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3357) TSP_1 PF00090.19 EGD94966.1 - 0.075 13.3 2.9 0.088 13.0 0.2 2.2 2 0 0 2 2 2 0 Thrombospondin type 1 domain Sugar_tr PF00083.24 EGD94967.1 - 7.2e-74 249.3 15.8 2.3e-73 247.6 15.8 1.6 1 1 1 2 2 2 1 Sugar (and other) transporter MFS_1 PF07690.16 EGD94967.1 - 9.9e-10 37.9 27.8 2.6e-09 36.5 27.8 1.7 1 1 0 1 1 1 1 Major Facilitator Superfamily DUF2207 PF09972.9 EGD94969.1 - 0.21 10.3 2.7 0.38 9.4 2.7 1.4 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) RNase_T PF00929.24 EGD94970.1 - 4.8e-27 95.5 0.0 5.5e-27 95.3 0.0 1.0 1 0 0 1 1 1 1 Exonuclease PGM_PMM_I PF02878.16 EGD94971.1 - 1.4e-33 115.6 0.2 2e-33 115.0 0.2 1.3 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_III PF02880.16 EGD94971.1 - 9.1e-26 90.3 0.0 1.7e-25 89.5 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.16 EGD94971.1 - 4.4e-17 62.6 0.0 1.1e-16 61.3 0.0 1.7 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.20 EGD94971.1 - 7.3e-09 35.7 0.0 1.7e-08 34.5 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain GFO_IDH_MocA PF01408.22 EGD94972.1 - 6.6e-10 39.9 0.0 1.3e-09 38.9 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 EGD94972.1 - 0.011 15.7 0.0 0.03 14.3 0.0 1.7 1 0 0 1 1 1 0 Oxidoreductase family, C-terminal alpha/beta domain HMG_CoA_synt_C PF08540.10 EGD94974.1 - 5e-104 347.8 0.2 6.3e-104 347.5 0.2 1.1 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase C terminal HMG_CoA_synt_N PF01154.17 EGD94974.1 - 4e-96 319.9 0.1 6.4e-96 319.2 0.1 1.3 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase N terminal TFR_dimer PF04253.15 EGD94975.1 - 1.3e-33 115.6 0.1 2.4e-33 114.8 0.1 1.5 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain Peptidase_M28 PF04389.17 EGD94975.1 - 3.2e-16 59.6 0.0 8.5e-16 58.2 0.0 1.7 2 0 0 2 2 2 1 Peptidase family M28 PA PF02225.22 EGD94975.1 - 1.3e-14 54.0 0.1 2.9e-14 52.9 0.1 1.6 1 0 0 1 1 1 1 PA domain TFIIB PF00382.19 EGD94976.1 - 3.6e-20 71.8 0.1 7.4e-20 70.8 0.1 1.6 1 0 0 1 1 1 1 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.12 EGD94976.1 - 6.9e-11 41.5 0.9 6.9e-11 41.5 0.9 1.9 2 0 0 2 2 2 1 TFIIB zinc-binding RB_B PF01857.20 EGD94976.1 - 0.00017 21.6 0.1 0.00027 21.0 0.1 1.2 1 0 0 1 1 1 1 Retinoblastoma-associated protein B domain Zn_ribbon_SprT PF17283.2 EGD94976.1 - 0.083 12.8 0.3 2.6 8.0 0.0 2.3 2 0 0 2 2 2 0 SprT-like zinc ribbon domain DZR PF12773.7 EGD94976.1 - 0.11 12.6 1.5 0.58 10.2 0.3 2.2 2 0 0 2 2 2 0 Double zinc ribbon DUF1610 PF07754.11 EGD94976.1 - 0.11 12.5 2.4 0.71 9.9 0.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1610) ATP_sub_h PF10775.9 EGD94977.1 - 2.1e-26 91.7 2.1 3.5e-26 91.0 2.1 1.4 1 0 0 1 1 1 1 ATP synthase complex subunit h Agouti PF05039.12 EGD94978.1 - 0.6 10.9 7.3 5.8 7.7 1.2 2.2 1 1 1 2 2 2 0 Agouti protein DUF1765 PF08578.10 EGD94979.1 - 5e-42 143.3 1.0 9.7e-42 142.4 1.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1765) Surp PF01805.20 EGD94980.1 - 6.4e-09 35.7 0.0 1.2e-08 34.8 0.0 1.5 1 0 0 1 1 1 1 Surp module RXT2_N PF08595.11 EGD94980.1 - 0.99 9.4 7.0 0.15 12.1 0.5 2.8 3 0 0 3 3 3 0 RXT2-like, N-terminal NTF2 PF02136.20 EGD94981.1 - 3.3e-33 114.8 0.1 3.7e-33 114.7 0.1 1.0 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain Mtr2 PF10429.9 EGD94981.1 - 0.044 13.7 0.0 0.05 13.5 0.0 1.1 1 0 0 1 1 1 0 Nuclear pore RNA shuttling protein Mtr2 DUF4518 PF15008.6 EGD94981.1 - 0.099 11.8 0.1 0.22 10.7 0.1 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4518) Cg6151-P PF10233.9 EGD94982.1 - 1.3e-39 135.0 12.1 1.6e-39 134.7 12.1 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein CG6151-P Trep_Strep PF09605.10 EGD94982.1 - 0.096 12.7 0.5 0.096 12.7 0.5 2.1 2 0 0 2 2 2 0 Hypothetical bacterial integral membrane protein (Trep_Strep) CbiN PF02553.15 EGD94982.1 - 1 9.4 4.2 0.49 10.4 0.4 2.2 2 0 0 2 2 2 0 Cobalt transport protein component CbiN DUF2721 PF11026.8 EGD94982.1 - 2.1 8.3 11.6 0.51 10.2 4.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) PRA1 PF03208.19 EGD94982.1 - 8.6 6.0 10.5 17 5.0 10.5 1.5 1 1 0 1 1 1 0 PRA1 family protein ABC2_membrane_2 PF12679.7 EGD94982.1 - 9.4 5.4 12.4 23 4.1 12.0 1.7 1 1 1 2 2 2 0 ABC-2 family transporter protein Aim21 PF11489.8 EGD94983.1 - 2.9e-133 446.4 91.7 3.1e-113 380.1 71.9 3.1 3 1 1 4 4 4 2 Altered inheritance of mitochondria protein 21 FAD_binding_4 PF01565.23 EGD94984.1 - 4.6e-23 81.5 2.5 7.2e-23 80.9 2.5 1.3 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EGD94984.1 - 1.6e-08 34.5 0.1 3.5e-08 33.4 0.1 1.6 1 0 0 1 1 1 1 Berberine and berberine like DUF2951 PF11166.8 EGD94986.1 - 0.028 14.6 0.0 0.065 13.4 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2951) Gly-zipper_Omp PF13488.6 EGD94986.1 - 0.39 10.8 6.4 0.84 9.7 6.4 1.5 1 0 0 1 1 1 0 Glycine zipper Bacteriocin_IIc PF10439.9 EGD94986.1 - 0.74 10.0 4.2 1.7 8.8 4.2 1.5 1 0 0 1 1 1 0 Bacteriocin class II with double-glycine leader peptide AIM3 PF17096.5 EGD94986.1 - 2.3 9.2 8.0 3.1 8.8 5.2 2.8 3 1 0 3 3 3 0 Altered inheritance of mitochondria protein 3 GREB1 PF15782.5 EGD94986.1 - 9.3 3.2 15.1 13 2.7 15.1 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Nucleo_P87 PF07267.11 EGD94987.1 - 0.11 11.4 7.4 0.12 11.3 7.4 1.0 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 RR_TM4-6 PF06459.12 EGD94987.1 - 2.9 7.7 11.4 3.3 7.5 11.4 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 PQ-loop PF04193.14 EGD94988.1 - 1.1e-18 66.7 16.6 1.2e-11 44.2 3.5 3.6 4 0 0 4 4 4 2 PQ loop repeat LtrA PF06772.11 EGD94988.1 - 0.0092 15.2 2.5 0.0092 15.2 2.5 2.3 1 1 2 3 3 3 1 Bacterial low temperature requirement A protein (LtrA) Arteri_GP4 PF02497.15 EGD94988.1 - 0.05 13.7 0.1 0.11 12.6 0.1 1.5 1 1 0 1 1 1 0 Arterivirus glycoprotein OppC_N PF12911.7 EGD94988.1 - 0.14 12.1 4.8 0.22 11.5 0.1 3.4 4 0 0 4 4 4 0 N-terminal TM domain of oligopeptide transport permease C TrbC PF04956.13 EGD94988.1 - 0.37 11.0 8.1 0.23 11.7 4.7 2.4 1 1 1 2 2 2 0 TrbC/VIRB2 family Ish1 PF10281.9 EGD94989.1 - 1e-83 275.3 17.6 5.3e-14 52.2 0.0 7.6 7 0 0 7 7 7 7 Putative stress-responsive nuclear envelope protein HeH PF12949.7 EGD94989.1 - 3.8e-08 32.9 0.7 0.33 10.7 0.0 5.2 5 0 0 5 5 5 3 HeH/LEM domain SAP PF02037.27 EGD94989.1 - 5.1e-07 29.3 0.0 0.74 9.6 0.0 4.5 4 0 0 4 4 4 2 SAP domain Slx4 PF09494.10 EGD94989.1 - 0.0014 18.5 0.2 20 5.3 0.0 4.7 5 0 0 5 5 5 0 Slx4 endonuclease ANAPC2 PF08672.11 EGD94989.1 - 0.0041 17.6 0.1 51 4.5 0.0 5.0 6 0 0 6 6 6 0 Anaphase promoting complex (APC) subunit 2 Recombinase PF07508.13 EGD94989.1 - 0.011 16.1 2.9 0.76 10.2 0.1 3.9 2 2 0 2 2 2 0 Recombinase LEM PF03020.15 EGD94989.1 - 0.017 14.6 0.0 12 5.6 0.0 3.4 4 0 0 4 4 4 0 LEM domain Endonuc-dimeris PF09124.10 EGD94989.1 - 0.058 13.6 0.0 20 5.5 0.0 4.0 5 0 0 5 5 5 0 T4 recombination endonuclease VII, dimerisation SAM_2 PF07647.17 EGD94989.1 - 0.15 12.2 0.3 79 3.5 0.0 4.5 5 0 0 5 5 5 0 SAM domain (Sterile alpha motif) EloA-BP1 PF15870.5 EGD94989.1 - 0.15 12.3 0.3 0.36 11.1 0.0 1.9 2 0 0 2 2 2 0 ElonginA binding-protein 1 YtxH PF12732.7 EGD94989.1 - 0.97 10.0 5.9 4.1 8.0 0.2 3.7 4 0 0 4 4 4 0 YtxH-like protein Cyt-b5 PF00173.28 EGD94990.1 - 3.6e-15 55.9 0.0 4.7e-15 55.5 0.0 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Filament PF00038.21 EGD94991.1 - 0.033 13.8 0.2 0.049 13.2 0.2 1.1 1 0 0 1 1 1 0 Intermediate filament protein Fib_alpha PF08702.10 EGD94991.1 - 0.067 13.4 2.7 0.18 12.0 2.7 1.7 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family Baculo_PEP_C PF04513.12 EGD94991.1 - 0.12 12.5 1.0 0.21 11.6 1.0 1.4 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Uds1 PF15456.6 EGD94991.1 - 0.36 11.0 1.5 6.7 6.9 0.9 2.3 1 1 1 2 2 2 0 Up-regulated During Septation TMA7 PF09072.10 EGD94992.1 - 5.6e-25 88.0 23.6 6.2e-25 87.8 23.6 1.0 1 0 0 1 1 1 1 Translation machinery associated TMA7 Pkinase PF00069.25 EGD94993.1 - 2.4e-53 181.2 0.0 3.9e-53 180.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD94993.1 - 1.7e-23 83.2 0.0 1e-22 80.7 0.0 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase Pox_ser-thr_kin PF05445.11 EGD94993.1 - 0.014 14.4 0.2 0.021 13.8 0.2 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Kinase-like PF14531.6 EGD94993.1 - 0.024 13.9 0.0 6 6.1 0.0 2.4 2 1 0 2 2 2 0 Kinase-like Pkinase_fungal PF17667.1 EGD94993.1 - 4.6 5.9 9.5 20 3.8 9.4 2.1 1 1 0 1 1 1 0 Fungal protein kinase Wound_ind PF08186.11 EGD94997.1 - 0.057 13.9 1.7 0.36 11.3 0.2 2.4 2 1 0 2 2 2 0 Wound-inducible basic protein family Pkinase PF00069.25 EGD94999.1 - 2.3e-53 181.3 0.0 3e-53 180.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD94999.1 - 1e-32 113.5 0.0 1.3e-32 113.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EGD94999.1 - 0.0018 17.6 0.0 0.0061 15.9 0.0 1.8 1 1 1 2 2 2 1 Kinase-like APH PF01636.23 EGD94999.1 - 0.0026 17.7 0.0 0.012 15.5 0.0 1.8 1 1 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 EGD94999.1 - 0.025 13.9 0.0 0.038 13.3 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 EGD94999.1 - 0.13 11.2 0.1 0.31 9.9 0.0 1.7 2 0 0 2 2 2 0 Haspin like kinase domain adh_short_C2 PF13561.6 EGD95000.1 - 4.3e-48 163.9 4.8 5.3e-40 137.4 3.6 2.0 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EGD95000.1 - 1.4e-45 155.1 3.3 1.8e-45 154.8 3.3 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EGD95000.1 - 5.4e-15 55.8 0.7 7.5e-15 55.3 0.7 1.2 1 0 0 1 1 1 1 KR domain 3HCDH_N PF02737.18 EGD95000.1 - 0.0042 17.0 0.5 0.0061 16.5 0.5 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain AdoHcyase_NAD PF00670.21 EGD95000.1 - 0.035 14.2 0.5 0.097 12.7 0.5 1.7 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain DDE_Tnp_1 PF01609.21 EGD95000.1 - 0.046 13.4 0.0 0.063 12.9 0.0 1.2 1 0 0 1 1 1 0 Transposase DDE domain GDP_Man_Dehyd PF16363.5 EGD95000.1 - 0.072 12.5 0.0 0.11 11.9 0.0 1.4 1 1 0 1 1 1 0 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 EGD95000.1 - 0.096 11.8 0.0 0.15 11.2 0.0 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 EGD95000.1 - 0.13 11.4 0.6 0.36 9.9 0.6 1.8 1 1 0 1 1 1 0 RmlD substrate binding domain ADH_zinc_N PF00107.26 EGD95000.1 - 0.16 12.0 2.7 0.65 10.0 1.4 2.5 2 1 0 2 2 2 0 Zinc-binding dehydrogenase HlyIII PF03006.20 EGD95001.1 - 7.7e-61 205.7 12.7 9.5e-61 205.4 12.7 1.1 1 0 0 1 1 1 1 Haemolysin-III related TPR_19 PF14559.6 EGD95003.1 - 1.5e-05 25.4 0.0 0.35 11.4 0.0 2.9 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_14 PF13428.6 EGD95003.1 - 0.0018 19.0 0.5 70 4.6 0.0 5.0 3 2 2 5 5 5 0 Tetratricopeptide repeat TPR_6 PF13174.6 EGD95003.1 - 0.0018 18.8 0.1 6.5 7.6 0.0 4.5 5 0 0 5 5 5 1 Tetratricopeptide repeat DUF4332 PF14229.6 EGD95003.1 - 0.0039 17.4 0.1 0.0089 16.3 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4332) PknG_TPR PF16918.5 EGD95003.1 - 0.007 15.1 0.0 0.017 13.9 0.0 1.5 1 1 0 1 1 1 1 Protein kinase G tetratricopeptide repeat TPR_12 PF13424.6 EGD95003.1 - 0.014 15.6 0.0 0.38 11.1 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_4 PF07721.14 EGD95003.1 - 0.025 15.2 0.2 39 5.3 0.1 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat Glycos_transf_2 PF00535.26 EGD95004.1 - 7.9e-35 120.2 0.0 9.9e-35 119.8 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 EGD95004.1 - 2.2e-14 53.9 0.0 2.7e-14 53.6 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 EGD95004.1 - 1.2e-06 28.2 0.0 1.7e-06 27.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 EGD95004.1 - 0.0019 17.7 0.0 0.003 17.1 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 21 UPA_2 PF17809.1 EGD95004.1 - 0.065 13.1 0.0 3.9 7.3 0.0 2.2 2 0 0 2 2 2 0 UPA domain DUF1749 PF08538.10 EGD95005.1 - 2.7e-89 299.2 0.0 3e-89 299.1 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1749) Hydrolase_4 PF12146.8 EGD95005.1 - 0.00018 20.9 0.0 0.0003 20.1 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Ser_hydrolase PF06821.13 EGD95005.1 - 0.0037 17.1 0.0 0.061 13.2 0.0 2.5 2 0 0 2 2 2 1 Serine hydrolase Abhydrolase_3 PF07859.13 EGD95005.1 - 0.069 13.0 0.0 0.11 12.3 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold DUF900 PF05990.12 EGD95005.1 - 0.14 11.6 0.0 0.2 11.1 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) Ge1_WD40 PF16529.5 EGD95006.1 - 0.045 12.7 0.0 0.072 12.0 0.0 1.2 1 0 0 1 1 1 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Vps35 PF03635.17 EGD95008.1 - 0 1019.0 0.4 0 1018.8 0.4 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 35 CobT PF06213.12 EGD95008.1 - 1.2 8.4 8.9 2.4 7.5 8.9 1.4 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT NST1 PF13945.6 EGD95009.1 - 6.3e-80 267.8 4.6 6.3e-80 267.8 4.6 4.7 3 2 2 5 5 5 1 Salt tolerance down-regulator Ras PF00071.22 EGD95010.1 - 2.9e-47 160.3 0.0 3.3e-47 160.1 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EGD95010.1 - 1.6e-20 73.5 0.0 2.4e-20 73.0 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EGD95010.1 - 2.8e-06 26.9 0.0 3.9e-06 26.4 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 EGD95010.1 - 0.0039 16.6 0.0 0.005 16.3 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 EGD95010.1 - 0.058 13.5 0.0 0.099 12.7 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase PduV-EutP PF10662.9 EGD95010.1 - 0.063 13.0 0.0 1.4 8.6 0.0 2.3 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Gtr1_RagA PF04670.12 EGD95010.1 - 0.076 12.4 0.0 0.094 12.1 0.0 1.3 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region ADH_zinc_N PF00107.26 EGD95010.1 - 0.12 12.4 0.0 16 5.5 0.0 2.3 2 0 0 2 2 2 0 Zinc-binding dehydrogenase AAA_21 PF13304.6 EGD95010.1 - 0.26 11.1 0.1 0.6 9.9 0.1 1.4 1 1 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system MRP-L28 PF09812.9 EGD95011.1 - 1.6e-05 25.1 0.1 2.1e-05 24.7 0.1 1.2 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L28 FANCL_C PF11793.8 EGD95012.1 - 4.2e-06 26.9 2.4 9.3e-06 25.7 2.4 1.6 1 0 0 1 1 1 1 FANCL C-terminal domain RINGv PF12906.7 EGD95012.1 - 7.2e-06 26.0 5.6 1.6e-05 24.9 5.6 1.7 1 0 0 1 1 1 1 RING-variant domain zf-TFIIB PF13453.6 EGD95012.1 - 0.0066 15.8 0.1 0.017 14.5 0.1 1.7 1 0 0 1 1 1 1 Transcription factor zinc-finger PhnA_Zn_Ribbon PF08274.12 EGD95012.1 - 0.0089 16.0 0.3 0.022 14.7 0.3 1.7 1 0 0 1 1 1 1 PhnA Zinc-Ribbon zf-RING_2 PF13639.6 EGD95012.1 - 0.014 15.7 4.5 0.044 14.1 4.5 1.9 1 0 0 1 1 1 0 Ring finger domain TPP_enzyme_C PF02775.21 EGD95013.1 - 3.8e-47 159.9 0.2 1.5e-46 157.9 0.0 2.0 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.22 EGD95013.1 - 4.1e-40 136.7 0.2 9.2e-40 135.6 0.2 1.6 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_N PF02776.18 EGD95013.1 - 7.7e-32 110.3 0.4 3.1e-29 101.8 0.0 3.5 3 0 0 3 3 3 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain GalKase_gal_bdg PF10509.9 EGD95014.1 - 1e-18 66.6 0.0 2.4e-18 65.4 0.0 1.7 1 0 0 1 1 1 1 Galactokinase galactose-binding signature GHMP_kinases_N PF00288.26 EGD95014.1 - 3.1e-14 52.9 1.6 6.3e-14 52.0 1.6 1.6 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 EGD95014.1 - 3.6e-11 43.3 0.0 9.4e-11 41.9 0.0 1.7 1 0 0 1 1 1 1 GHMP kinases C terminal Crp PF00325.20 EGD95014.1 - 0.17 11.6 0.1 10 5.9 0.1 2.4 2 0 0 2 2 2 0 Bacterial regulatory proteins, crp family Ydr279_N PF17745.1 EGD95015.1 - 7.3e-22 77.4 0.1 2e-21 76.0 0.0 1.8 2 0 0 2 2 2 1 Ydr279p protein triple barrel domain RNase_H2-Ydr279 PF09468.10 EGD95015.1 - 1.8e-21 77.0 1.0 1.8e-21 77.0 1.0 2.9 1 1 1 2 2 2 1 Ydr279p protein family (RNase H2 complex component) wHTH domain U1snRNP70_N PF12220.8 EGD95015.1 - 0.01 16.4 3.0 0.012 16.2 0.8 2.2 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal HAUS-augmin3 PF14932.6 EGD95015.1 - 0.32 10.5 8.4 0.097 12.2 5.4 1.6 1 1 0 1 1 1 0 HAUS augmin-like complex subunit 3 RNA_pol_Rpc4 PF05132.14 EGD95015.1 - 1.4 9.3 10.3 2.9 8.3 0.2 2.8 3 0 0 3 3 3 0 RNA polymerase III RPC4 CCDC53 PF10152.9 EGD95015.1 - 1.6 9.2 9.6 0.37 11.2 1.4 2.6 3 0 0 3 3 3 0 Subunit CCDC53 of WASH complex CPSF100_C PF13299.6 EGD95015.1 - 2.8 8.1 7.9 14 5.8 0.4 2.4 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal zf-primase PF09329.11 EGD95016.1 - 5.6e-20 70.9 1.0 9.7e-20 70.1 1.0 1.4 1 0 0 1 1 1 1 Primase zinc finger Sugarporin_N PF11471.8 EGD95016.1 - 1.2 9.1 5.2 4.4 7.3 5.2 2.0 1 0 0 1 1 1 0 Maltoporin periplasmic N-terminal extension DASH_Duo1 PF08651.10 EGD95018.1 - 6.4e-32 109.2 0.1 1.1e-31 108.5 0.1 1.4 1 0 0 1 1 1 1 DASH complex subunit Duo1 DUF745 PF05335.13 EGD95018.1 - 0.0043 16.8 4.2 0.0078 15.9 4.2 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF745) Retinal PF15449.6 EGD95018.1 - 0.0055 14.6 11.0 0.0071 14.2 11.0 1.1 1 0 0 1 1 1 1 Retinal protein PEARLI-4 PF05278.12 EGD95018.1 - 0.023 14.3 4.4 0.048 13.3 4.4 1.5 1 0 0 1 1 1 0 Arabidopsis phospholipase-like protein (PEARLI 4) 3HCDH_N PF02737.18 EGD95018.1 - 0.15 12.0 4.1 0.42 10.5 0.1 2.1 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Fmp27_GFWDK PF10347.9 EGD95018.1 - 0.68 10.0 2.1 0.82 9.8 0.1 1.8 1 1 1 2 2 2 0 RNA pol II promoter Fmp27 protein domain U79_P34 PF03064.16 EGD95018.1 - 4.3 6.6 11.3 2.6 7.4 9.1 1.5 1 1 0 1 1 1 0 HSV U79 / HCMV P34 SH3_1 PF00018.28 EGD95020.1 - 6.5e-13 48.1 0.0 1.5e-12 46.9 0.0 1.6 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 EGD95020.1 - 2e-11 43.6 0.0 2.4e-10 40.1 0.0 2.2 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.17 EGD95020.1 - 8.6e-11 41.4 0.0 3.3e-10 39.5 0.0 2.0 2 0 0 2 2 2 1 Variant SH3 domain FCH PF00611.23 EGD95021.1 - 1.3e-15 57.5 0.0 3e-15 56.3 0.0 1.7 1 0 0 1 1 1 1 Fes/CIP4, and EFC/F-BAR homology domain Glyco_hydro_15 PF00723.21 EGD95021.1 - 0.0025 16.7 0.2 0.0036 16.1 0.2 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 15 Rapsyn_N PF10579.9 EGD95021.1 - 0.013 15.6 0.1 0.025 14.7 0.1 1.5 1 0 0 1 1 1 0 Rapsyn N-terminal myristoylation and linker region Not1 PF04054.15 EGD95022.1 - 8.1e-141 469.2 3.7 8.9e-141 469.1 0.3 2.6 3 0 0 3 3 3 1 CCR4-Not complex component, Not1 CNOT1_CAF1_bind PF16415.5 EGD95022.1 - 3.6e-93 311.1 3.5 1.2e-92 309.4 3.5 1.9 1 0 0 1 1 1 1 CCR4-NOT transcription complex subunit 1 CAF1-binding domain DUF3819 PF12842.7 EGD95022.1 - 4.3e-51 172.7 2.0 1e-50 171.5 2.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF3819) CNOT1_TTP_bind PF16417.5 EGD95022.1 - 6.7e-40 136.3 0.0 6.7e-40 136.3 0.0 2.4 2 0 0 2 2 2 1 CCR4-NOT transcription complex subunit 1 TTP binding domain CNOT1_HEAT PF16418.5 EGD95022.1 - 7.3e-29 100.8 4.2 1.4e-28 99.8 0.0 2.7 2 0 0 2 2 2 1 CCR4-NOT transcription complex subunit 1 HEAT repeat TTL PF03133.15 EGD95023.1 - 5.1e-55 186.7 0.0 7.6e-55 186.1 0.0 1.1 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family SurE PF01975.17 EGD95023.1 - 3.3e-33 115.1 0.0 5e-33 114.5 0.0 1.2 1 0 0 1 1 1 1 Survival protein SurE ATPgrasp_YheCD PF14398.6 EGD95023.1 - 0.0036 16.6 0.0 0.0066 15.7 0.0 1.3 1 0 0 1 1 1 1 YheC/D like ATP-grasp ABC_tran PF00005.27 EGD95025.1 - 1.5e-33 116.2 0.0 2.7e-33 115.4 0.0 1.4 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 EGD95025.1 - 3.8e-24 85.8 0.4 3.8e-24 85.8 0.4 2.3 2 0 0 2 2 2 1 ABC transporter transmembrane region SMC_N PF02463.19 EGD95025.1 - 3e-05 23.6 0.2 0.0022 17.4 0.0 2.3 1 1 1 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 EGD95025.1 - 0.0031 18.0 0.5 0.015 15.8 0.2 2.1 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 EGD95025.1 - 0.012 15.4 0.2 0.036 13.8 0.2 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_10 PF12846.7 EGD95025.1 - 0.059 12.3 0.0 0.1 11.5 0.0 1.3 1 0 0 1 1 1 0 AAA-like domain SbcCD_C PF13558.6 EGD95025.1 - 0.064 13.5 0.1 0.37 11.0 0.1 2.4 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit RsgA_GTPase PF03193.16 EGD95025.1 - 0.083 12.8 0.0 0.17 11.8 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase AAA_22 PF13401.6 EGD95025.1 - 0.087 13.1 0.3 0.32 11.3 0.3 2.0 1 1 0 1 1 1 0 AAA domain AAA_15 PF13175.6 EGD95025.1 - 0.2 11.3 0.0 0.33 10.6 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain Pex14_N PF04695.13 EGD95027.1 - 1.8e-40 139.2 0.0 1.8e-40 139.2 0.0 3.3 2 1 1 3 3 3 1 Peroxisomal membrane anchor protein (Pex14p) conserved region Golgin_A5 PF09787.9 EGD95027.1 - 0.0027 17.2 1.2 0.0046 16.5 1.2 1.3 1 0 0 1 1 1 1 Golgin subfamily A member 5 DUF1043 PF06295.12 EGD95027.1 - 0.032 14.2 0.3 0.09 12.8 0.3 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1043) SYCE1 PF15233.6 EGD95027.1 - 0.092 12.8 4.2 0.17 12.0 4.2 1.3 1 0 0 1 1 1 0 Synaptonemal complex central element protein 1 LMBR1 PF04791.16 EGD95027.1 - 0.11 11.4 0.0 0.15 10.9 0.0 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Baculo_PEP_C PF04513.12 EGD95027.1 - 0.38 10.8 1.9 1.3 9.1 1.6 1.9 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus zf-C4H2 PF10146.9 EGD95027.1 - 0.78 10.0 6.4 0.12 12.7 2.0 1.9 2 1 0 2 2 2 0 Zinc finger-containing protein DUF1664 PF07889.12 EGD95027.1 - 1.1 9.3 2.6 6.5 6.8 1.9 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DUF3584 PF12128.8 EGD95027.1 - 4.3 4.7 14.0 0.014 13.0 4.8 1.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) Ndc80_HEC PF03801.13 EGD95028.1 - 2.1e-60 202.8 0.5 4e-60 201.9 0.5 1.5 1 0 0 1 1 1 1 HEC/Ndc80p family Spc7 PF08317.11 EGD95028.1 - 0.013 14.4 39.9 0.21 10.4 18.8 2.9 2 0 0 2 2 2 0 Spc7 kinetochore protein DUF812 PF05667.11 EGD95028.1 - 0.058 12.3 32.6 0.014 14.4 14.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF812) ProRS-C_2 PF09181.10 EGD95028.1 - 0.39 10.9 3.8 11 6.3 0.5 3.0 2 0 0 2 2 2 0 Prolyl-tRNA synthetase, C-terminal TPR_MLP1_2 PF07926.12 EGD95028.1 - 2.9 7.9 45.4 1 9.4 3.7 4.1 3 1 1 4 4 4 0 TPR/MLP1/MLP2-like protein Cep57_CLD PF14073.6 EGD95028.1 - 4.1 7.4 43.5 0.14 12.1 18.5 3.2 2 1 1 3 3 3 0 Centrosome localisation domain of Cep57 Golgin_A5 PF09787.9 EGD95028.1 - 5.7 6.3 46.0 1.2 8.6 14.7 3.3 2 1 1 3 3 3 0 Golgin subfamily A member 5 CEP63 PF17045.5 EGD95028.1 - 7.2 6.4 40.0 0.96 9.3 12.0 3.3 2 1 1 3 3 3 0 Centrosomal protein of 63 kDa Pkinase PF00069.25 EGD95030.1 - 1.9e-54 184.8 0.0 3.7e-54 183.8 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD95030.1 - 7.2e-22 77.9 0.0 1.7e-21 76.7 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EGD95030.1 - 0.047 12.6 0.2 0.074 12.0 0.2 1.2 1 0 0 1 1 1 0 Haspin like kinase domain Pkinase_fungal PF17667.1 EGD95030.1 - 0.051 12.3 0.0 0.1 11.3 0.0 1.4 1 0 0 1 1 1 0 Fungal protein kinase APH PF01636.23 EGD95030.1 - 0.14 12.1 1.1 3 7.7 0.2 2.2 1 1 1 2 2 2 0 Phosphotransferase enzyme family FolB PF02152.18 EGD95031.1 - 1.3e-27 96.6 0.6 1.9e-22 79.9 0.5 2.5 3 0 0 3 3 3 2 Dihydroneopterin aldolase RRM_1 PF00076.22 EGD95032.1 - 2.3e-17 62.6 0.1 9.6e-08 31.7 0.0 3.1 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 EGD95032.1 - 0.087 12.9 0.0 1.3 9.1 0.0 2.0 2 0 0 2 2 2 0 RNA binding motif ETF_QO PF05187.13 EGD95033.1 - 6.6e-42 141.9 0.9 1.4e-24 86.2 0.0 2.4 2 0 0 2 2 2 2 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S DAO PF01266.24 EGD95033.1 - 1.8e-09 37.6 0.0 1.8e-05 24.5 0.0 2.3 2 0 0 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EGD95033.1 - 2.9e-05 24.2 0.0 8.1e-05 22.8 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 EGD95033.1 - 3.9e-05 22.9 0.0 0.0029 16.8 0.0 2.2 2 0 0 2 2 2 1 FAD binding domain Pyr_redox PF00070.27 EGD95033.1 - 0.00028 21.4 0.1 0.24 12.0 0.0 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 EGD95033.1 - 0.00055 19.3 0.4 0.0014 18.0 0.1 1.8 2 0 0 2 2 2 1 FAD binding domain NAD_binding_9 PF13454.6 EGD95033.1 - 0.00056 19.9 0.0 0.001 19.1 0.0 1.4 1 0 0 1 1 1 1 FAD-NAD(P)-binding HI0933_like PF03486.14 EGD95033.1 - 0.00092 18.0 0.1 0.0014 17.4 0.1 1.3 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox_2 PF07992.14 EGD95033.1 - 0.0012 18.1 0.0 0.0036 16.6 0.0 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 EGD95033.1 - 0.0017 17.3 0.0 0.03 13.2 0.0 2.1 2 0 0 2 2 2 1 Tryptophan halogenase FAD_oxidored PF12831.7 EGD95033.1 - 0.0019 17.6 0.1 0.0033 16.8 0.1 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.17 EGD95033.1 - 0.0025 17.1 0.0 0.01 15.1 0.0 1.7 2 0 0 2 2 2 1 Thi4 family Pyr_redox_3 PF13738.6 EGD95033.1 - 0.008 15.5 0.2 0.012 14.9 0.2 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EGD95033.1 - 0.16 11.0 0.4 0.25 10.4 0.4 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A TBP PF00352.21 EGD95034.1 - 1.8e-67 223.3 0.1 9.3e-33 112.0 0.1 2.1 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) DUF3378 PF11858.8 EGD95034.1 - 5.5e-05 23.2 0.0 0.23 11.6 0.0 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF3378) DUF4295 PF14128.6 EGD95034.1 - 0.13 12.1 0.1 0.69 9.8 0.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4295) DAO PF01266.24 EGD95035.1 - 8.4e-48 163.7 0.5 1e-47 163.5 0.5 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EGD95035.1 - 6.3e-09 35.5 0.0 0.0029 16.9 0.0 2.5 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 EGD95035.1 - 5.7e-06 25.5 0.4 0.023 13.6 0.1 2.1 2 0 0 2 2 2 2 Tryptophan halogenase NAD_binding_9 PF13454.6 EGD95035.1 - 6.1e-06 26.3 0.2 0.037 14.0 0.0 2.4 2 0 0 2 2 2 2 FAD-NAD(P)-binding GIDA PF01134.22 EGD95035.1 - 6.4e-06 25.5 0.1 7.8e-05 21.9 0.0 2.0 2 0 0 2 2 2 1 Glucose inhibited division protein A NAD_binding_8 PF13450.6 EGD95035.1 - 0.00022 21.4 0.0 0.0006 20.0 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 EGD95035.1 - 0.0015 17.7 0.7 0.93 8.5 0.1 2.2 2 0 0 2 2 2 2 FAD binding domain FAD_binding_3 PF01494.19 EGD95035.1 - 0.0028 17.0 0.3 1.4 8.1 0.2 2.2 2 0 0 2 2 2 2 FAD binding domain Pyr_redox PF00070.27 EGD95035.1 - 0.02 15.4 0.0 0.052 14.1 0.0 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EGD95035.1 - 0.035 13.2 0.1 0.88 8.6 0.0 2.1 2 0 0 2 2 2 0 Lycopene cyclase protein GMC_oxred_N PF00732.19 EGD95035.1 - 0.048 13.0 0.0 1.7 7.9 0.0 2.6 3 0 0 3 3 3 0 GMC oxidoreductase Methyltransf_23 PF13489.6 EGD95036.1 - 2.1e-27 96.0 0.0 3.1e-27 95.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EGD95036.1 - 5.7e-05 23.7 0.0 0.00052 20.7 0.0 2.5 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EGD95036.1 - 0.009 16.7 0.0 0.018 15.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EGD95036.1 - 0.027 15.1 0.0 0.082 13.6 0.0 1.9 1 1 0 1 1 1 0 Methyltransferase domain CENP-B_dimeris PF09026.10 EGD95037.1 - 0.24 11.8 8.2 0.23 11.9 6.3 2.0 2 0 0 2 2 2 0 Centromere protein B dimerisation domain Cyclin_N PF00134.23 EGD95038.1 - 3.1e-14 52.8 0.1 6.3e-14 51.8 0.1 1.5 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 EGD95038.1 - 0.0021 18.2 0.0 0.04 14.0 0.0 2.5 2 0 0 2 2 2 1 Cyclin, C-terminal domain TFIIB PF00382.19 EGD95038.1 - 0.0033 17.4 1.9 0.064 13.3 0.0 2.5 2 0 0 2 2 2 1 Transcription factor TFIIB repeat PPP4R2 PF09184.11 EGD95038.1 - 8 6.0 15.1 12 5.4 15.1 1.2 1 0 0 1 1 1 0 PPP4R2 EAF PF09816.9 EGD95039.1 - 2.3e-16 60.0 0.1 2.3e-16 60.0 0.1 2.3 3 0 0 3 3 3 1 RNA polymerase II transcription elongation factor Dor1 PF04124.12 EGD95040.1 - 1.5e-52 178.4 0.6 7.3e-43 146.5 0.6 2.5 1 1 1 2 2 2 2 Dor1-like family Sec8_exocyst PF04048.14 EGD95040.1 - 0.023 14.6 0.6 0.063 13.2 0.6 1.7 1 0 0 1 1 1 0 Sec8 exocyst complex component specific domain Vps51 PF08700.11 EGD95040.1 - 0.059 13.5 2.2 0.083 13.0 0.4 2.2 2 0 0 2 2 2 0 Vps51/Vps67 Snf7 PF03357.21 EGD95040.1 - 6.7 6.3 6.6 0.29 10.7 0.7 1.8 2 0 0 2 2 2 0 Snf7 COG5 PF10392.9 EGD95040.1 - 6.9 6.9 9.9 9.8 6.4 3.7 3.5 3 1 0 3 3 3 0 Golgi transport complex subunit 5 His_Phos_1 PF00300.22 EGD95041.1 - 8.5e-30 103.9 0.0 1.8e-29 102.9 0.0 1.5 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) His_Phos_2 PF00328.22 EGD95041.1 - 0.0033 16.8 0.0 0.0062 15.9 0.0 1.4 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) YL1 PF05764.13 EGD95041.1 - 2.6 8.1 9.9 0.33 11.1 2.7 2.6 3 0 0 3 3 3 0 YL1 nuclear protein Zn_clus PF00172.18 EGD95042.1 - 4.2e-07 30.0 6.7 4.2e-07 30.0 6.7 1.7 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 EGD95042.1 - 2.7e-05 23.2 4.0 3.9e-05 22.6 3.5 1.4 2 0 0 2 2 2 1 Fungal specific transcription factor domain PocR PF10114.9 EGD95042.1 - 1 9.1 2.8 2 8.2 2.8 1.5 1 0 0 1 1 1 0 Sensory domain found in PocR Abhydrolase_1 PF00561.20 EGD95043.1 - 2.1e-06 27.6 0.0 4.1e-06 26.6 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EGD95043.1 - 6.3e-06 27.0 0.0 9.7e-06 26.3 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EGD95043.1 - 8.5e-05 21.9 0.0 0.00018 20.9 0.0 1.5 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 EGD95043.1 - 0.036 13.6 0.1 7.2 6.0 0.0 2.4 2 0 0 2 2 2 0 Prolyl oligopeptidase family Peptidase_M43 PF05572.13 EGD95046.1 - 5.7e-17 62.0 0.2 1.1e-16 61.1 0.2 1.4 1 0 0 1 1 1 1 Pregnancy-associated plasma protein-A Reprolysin_3 PF13582.6 EGD95046.1 - 4.9e-06 27.1 0.7 4.8e-05 23.9 0.7 2.3 1 1 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.6 EGD95046.1 - 4.1e-05 23.8 3.6 0.0001 22.5 3.6 1.6 1 1 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_4 PF13583.6 EGD95046.1 - 0.0002 21.0 3.4 0.0017 18.1 1.8 2.3 2 1 0 2 2 2 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M10 PF00413.24 EGD95046.1 - 0.0055 16.6 0.0 0.0075 16.1 0.0 1.3 1 0 0 1 1 1 1 Matrixin Reprolysin_2 PF13574.6 EGD95046.1 - 0.012 15.6 0.7 0.016 15.1 0.7 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Astacin PF01400.24 EGD95046.1 - 0.074 12.7 0.1 0.2 11.2 0.0 1.7 2 0 0 2 2 2 0 Astacin (Peptidase family M12A) Peptidase_M57 PF12388.8 EGD95046.1 - 0.12 12.0 2.6 0.14 11.7 0.8 1.9 2 0 0 2 2 2 0 Dual-action HEIGH metallo-peptidase DUF4953 PF16313.5 EGD95046.1 - 0.12 11.6 0.0 0.21 10.8 0.0 1.3 1 0 0 1 1 1 0 Met-zincin KCH PF16944.5 EGD95047.1 - 1.9e-99 332.6 9.9 2.2e-99 332.3 9.9 1.1 1 0 0 1 1 1 1 Fungal potassium channel DUF747 PF05346.11 EGD95048.1 - 2.8e-118 395.0 9.0 3.8e-118 394.6 9.0 1.2 1 0 0 1 1 1 1 Eukaryotic membrane protein family DUF4834 PF16118.5 EGD95048.1 - 0.3 12.1 2.6 0.48 11.4 0.0 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) p450 PF00067.22 EGD95049.1 - 2.4e-70 237.6 0.0 2.8e-70 237.3 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Peptidase_M20 PF01546.28 EGD95050.1 - 4.2e-21 75.6 0.0 8.2e-20 71.4 0.0 2.2 2 0 0 2 2 2 1 Peptidase family M20/M25/M40 WD40 PF00400.32 EGD95050.1 - 2.7e-14 53.3 14.2 0.017 16.0 0.1 6.5 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EGD95050.1 - 0.00023 21.4 0.1 2 8.8 0.0 4.0 3 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain M20_dimer PF07687.14 EGD95050.1 - 0.00084 19.2 0.0 0.002 18.0 0.0 1.6 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 EGD95050.1 - 0.0014 18.4 0.0 0.0028 17.3 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M28 MtN3_slv PF03083.16 EGD95051.1 - 0.0062 16.6 0.0 0.0078 16.2 0.0 1.1 1 0 0 1 1 1 1 Sugar efflux transporter for intercellular exchange FolB PF02152.18 EGD95051.1 - 0.11 13.0 0.0 0.12 12.9 0.0 1.2 1 0 0 1 1 1 0 Dihydroneopterin aldolase TraQ PF09679.10 EGD95052.1 - 0.073 13.0 1.2 0.22 11.5 0.0 2.2 2 0 0 2 2 2 0 Type-F conjugative transfer system pilin chaperone (TraQ) Dsh_C PF12316.8 EGD95052.1 - 2.6 8.4 17.0 3.1 8.2 4.2 2.4 2 0 0 2 2 2 0 Segment polarity protein dishevelled (Dsh) C terminal Tim17 PF02466.19 EGD95053.1 - 2e-32 111.9 8.4 2.5e-32 111.6 8.4 1.1 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family Asparaginase_2 PF01112.18 EGD95054.1 - 1.4e-51 175.3 0.0 1.1e-49 169.1 0.0 3.3 2 1 0 2 2 2 1 Asparaginase p450 PF00067.22 EGD95055.1 - 1.6e-52 178.9 0.0 2.4e-29 102.4 0.0 2.0 1 1 1 2 2 2 2 Cytochrome P450 RTP1_C2 PF10304.9 EGD95056.1 - 0.13 11.9 0.0 0.23 11.2 0.0 1.5 1 0 0 1 1 1 0 Required for nuclear transport of RNA pol II C-terminus 2 Peptidase_S8 PF00082.22 EGD95057.1 - 7.7e-30 104.2 12.7 1.7e-29 103.0 12.7 1.5 1 1 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 EGD95057.1 - 4.4e-17 62.5 0.1 7.8e-17 61.7 0.1 1.4 1 0 0 1 1 1 1 Peptidase inhibitor I9 Flavoprotein PF02441.19 EGD95058.1 - 1.6e-12 47.4 0.0 2.6e-12 46.8 0.0 1.3 1 0 0 1 1 1 1 Flavoprotein Ank_4 PF13637.6 EGD95058.1 - 0.0058 17.2 0.2 42 4.9 0.0 4.3 3 1 2 5 5 5 2 Ankyrin repeats (many copies) MFS_1 PF07690.16 EGD95059.1 - 1.7e-45 155.5 45.6 1.7e-45 155.5 45.6 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EGD95059.1 - 5.2e-15 55.3 13.5 5.2e-15 55.3 13.5 2.8 3 0 0 3 3 3 2 Sugar (and other) transporter RICTOR_V PF14668.6 EGD95059.1 - 0.028 14.6 0.0 0.1 12.8 0.0 2.0 1 0 0 1 1 1 0 Rapamycin-insensitive companion of mTOR, domain 5 Pox_EPC_I2-L1 PF12575.8 EGD95059.1 - 5.4 7.3 5.4 6.7 7.0 0.1 3.2 3 0 0 3 3 3 0 Poxvirus entry protein complex L1 and I2 MFS_1_like PF12832.7 EGD95059.1 - 7.1 5.4 28.2 0.04 12.8 9.5 2.9 3 1 0 3 3 3 0 MFS_1 like family Cerato-platanin PF07249.12 EGD95060.1 - 6e-43 145.7 0.3 7.4e-43 145.4 0.3 1.1 1 0 0 1 1 1 1 Cerato-platanin Barwin PF00967.17 EGD95060.1 - 0.0026 17.6 0.2 0.0055 16.5 0.2 1.6 1 1 0 1 1 1 1 Barwin family GLTT PF01744.20 EGD95060.1 - 0.32 10.8 1.7 1.1 9.1 0.4 2.2 2 0 0 2 2 2 0 GLTT repeat (6 copies) Sulfotransfer_3 PF13469.6 EGD95061.1 - 0.01 16.2 0.0 0.27 11.6 0.0 2.3 2 0 0 2 2 2 0 Sulfotransferase family D123 PF07065.14 EGD95062.1 - 0.0052 16.0 0.0 0.029 13.5 0.0 1.9 1 1 0 1 1 1 1 D123 R2K_3 PF14243.6 EGD95062.1 - 0.028 14.4 0.0 0.097 12.7 0.0 1.9 1 1 0 1 1 1 0 ATP-grasp domain, R2K clade family 3 R2K_2 PF18299.1 EGD95062.1 - 0.038 13.8 0.0 0.085 12.7 0.0 1.5 1 0 0 1 1 1 0 ATP-grasp domain, R2K clade family 2 DUF2011 PF09428.10 EGD95064.1 - 1.5e-28 98.8 0.1 7.1e-28 96.7 0.0 2.1 2 0 0 2 2 2 1 Fungal protein of unknown function (DUF2011) TRAP-gamma PF07074.12 EGD95064.1 - 0.68 9.5 2.2 1.1 8.8 2.2 1.3 1 0 0 1 1 1 0 Translocon-associated protein, gamma subunit (TRAP-gamma) LAMTOR PF15454.6 EGD95065.1 - 3.3e-11 43.6 0.3 1.2e-10 41.8 0.0 2.0 2 0 0 2 2 2 1 Late endosomal/lysosomal adaptor and MAPK and MTOR activator UQ_con PF00179.26 EGD95067.1 - 2.7e-36 124.3 0.7 1.2e-35 122.2 0.7 1.8 1 1 0 1 1 1 1 Ubiquitin-conjugating enzyme Pox_P21 PF05313.12 EGD95068.1 - 2.2 7.8 10.3 0.11 12.1 1.3 2.7 3 0 0 3 3 3 0 Poxvirus P21 membrane protein APG12 PF04110.13 EGD95070.1 - 6.1e-27 93.9 0.0 9e-27 93.3 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 Atg8 PF02991.16 EGD95070.1 - 0.037 14.2 0.0 0.05 13.8 0.0 1.3 1 0 0 1 1 1 0 Autophagy protein Atg8 ubiquitin like Pantoate_transf PF02548.15 EGD95071.1 - 2.1e-106 355.1 1.9 2.5e-106 354.8 1.9 1.1 1 0 0 1 1 1 1 Ketopantoate hydroxymethyltransferase PEP_mutase PF13714.6 EGD95071.1 - 4.2e-10 39.5 0.7 6e-10 39.0 0.1 1.6 2 0 0 2 2 2 1 Phosphoenolpyruvate phosphomutase YjcQ PF09639.10 EGD95071.1 - 0.15 12.3 0.1 0.34 11.1 0.1 1.5 1 0 0 1 1 1 0 YjcQ protein Dfp1_Him1_M PF08630.10 EGD95072.1 - 1.3e-36 125.6 0.1 1.3e-36 125.6 0.1 2.5 2 0 0 2 2 2 1 Dfp1/Him1, central region zf-DBF PF07535.12 EGD95072.1 - 1.3e-18 66.9 0.3 1.3e-18 66.9 0.3 1.6 2 0 0 2 2 2 1 DBF zinc finger PTCB-BRCT PF12738.7 EGD95072.1 - 0.015 15.2 0.0 0.036 14.0 0.0 1.6 1 0 0 1 1 1 0 twin BRCT domain BRCT PF00533.26 EGD95072.1 - 0.031 14.7 0.0 0.12 12.8 0.0 2.0 1 0 0 1 1 1 0 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 EGD95072.1 - 0.11 12.9 0.0 0.41 11.1 0.0 2.0 1 0 0 1 1 1 0 BRCT domain, a BRCA1 C-terminus domain AMP_N PF05195.16 EGD95073.1 - 1.5e-37 128.1 0.0 2.3e-37 127.4 0.0 1.3 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain Peptidase_M24 PF00557.24 EGD95073.1 - 2e-35 122.4 0.0 8.9e-33 113.7 0.0 2.5 1 1 1 2 2 2 2 Metallopeptidase family M24 FR47 PF08445.10 EGD95074.1 - 4.3e-09 36.2 0.1 2e-06 27.7 0.1 2.5 1 1 0 1 1 1 1 FR47-like protein Acetyltransf_3 PF13302.7 EGD95074.1 - 3.2e-06 27.9 0.1 1.4e-05 25.8 0.0 2.1 1 1 1 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EGD95074.1 - 8.8e-05 22.7 0.0 0.00043 20.5 0.0 2.1 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EGD95074.1 - 0.073 13.5 0.0 0.13 12.7 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 EGD95074.1 - 0.087 13.0 0.0 0.17 12.0 0.0 1.4 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase ADH_zinc_N PF00107.26 EGD95075.1 - 2.7e-20 72.7 0.0 5.1e-20 71.8 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EGD95075.1 - 7.5e-13 49.7 0.0 1.5e-12 48.7 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EGD95075.1 - 6.4e-07 29.2 0.0 2.7e-06 27.2 0.0 1.9 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Pyridox_ox_2 PF12900.7 EGD95076.1 - 5.7e-37 126.8 0.0 8.4e-37 126.3 0.0 1.3 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase SIR2 PF02146.17 EGD95077.1 - 6.9e-37 127.1 0.0 3.2e-36 124.9 0.0 1.8 1 1 0 1 1 1 1 Sir2 family MFS_1 PF07690.16 EGD95078.1 - 5.3e-38 130.8 20.4 8.8e-21 74.2 5.7 2.0 2 0 0 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 EGD95078.1 - 1.1e-13 50.6 24.6 2e-05 23.4 7.3 3.1 3 0 0 3 3 3 3 MFS/sugar transport protein MFS_1_like PF12832.7 EGD95078.1 - 2.8e-07 29.7 19.6 0.00017 20.6 0.8 2.1 1 1 1 2 2 2 2 MFS_1 like family Sugar_tr PF00083.24 EGD95078.1 - 7.9e-05 21.7 21.3 0.00067 18.6 21.3 2.5 1 1 0 1 1 1 1 Sugar (and other) transporter OATP PF03137.20 EGD95078.1 - 0.026 12.8 14.1 0.36 9.0 2.1 3.3 1 1 2 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family DUF3938 PF13074.6 EGD95078.1 - 0.17 12.1 4.2 1.8 8.9 0.2 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3938) Trp_oprn_chp PF09534.10 EGD95078.1 - 0.78 9.5 5.5 16 5.2 5.5 2.6 1 1 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) MFS_3 PF05977.13 EGD95078.1 - 1.2 7.5 18.7 0.009 14.4 4.0 2.6 3 0 0 3 3 3 0 Transmembrane secretion effector BT1 PF03092.16 EGD95078.1 - 1.7 6.8 10.8 1.5 7.0 0.0 3.7 4 1 1 5 5 5 0 BT1 family CoA_binding_3 PF13727.6 EGD95078.1 - 7.1 6.6 10.0 0.86 9.6 5.2 1.9 2 0 0 2 2 2 0 CoA-binding domain MFS_1 PF07690.16 EGD95079.1 - 1e-24 87.2 55.4 1.2e-22 80.4 47.5 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily PALP PF00291.25 EGD95080.1 - 6.9e-49 166.8 0.8 7.1e-48 163.5 0.8 2.0 1 1 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme GRDA PF04723.14 EGD95080.1 - 0.082 12.7 0.1 0.16 11.8 0.1 1.4 1 0 0 1 1 1 0 Glycine reductase complex selenoprotein A SRR1 PF07985.12 EGD95081.1 - 5.4e-10 39.2 0.0 8e-10 38.6 0.0 1.2 1 0 0 1 1 1 1 SRR1 SNF2_N PF00176.23 EGD95082.1 - 7.3e-67 225.5 0.0 3.4e-65 220.1 0.0 2.8 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EGD95082.1 - 9.1e-16 58.2 0.0 3.9e-15 56.2 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 EGD95082.1 - 1.1e-05 25.3 0.0 3.8e-05 23.5 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.15 EGD95082.1 - 8.2e-05 22.7 0.0 0.00024 21.1 0.0 1.9 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit PPV_E1_N PF00524.18 EGD95082.1 - 0.011 16.1 0.6 0.051 14.0 0.6 2.2 1 0 0 1 1 1 0 E1 Protein, N terminal domain Nop25 PF09805.9 EGD95082.1 - 1.9 9.0 18.1 4.2 7.8 5.7 3.1 2 0 0 2 2 2 0 Nucleolar protein 12 (25kDa) DUF3736 PF12540.8 EGD95082.1 - 3.2 7.9 11.8 0.44 10.6 0.4 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF3736) Pkinase PF00069.25 EGD95083.1 - 8.6e-64 215.4 0.0 1e-63 215.2 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD95083.1 - 7.6e-34 117.2 0.0 9.5e-34 116.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EGD95083.1 - 2.3e-06 27.1 0.0 3.6e-06 26.5 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EGD95083.1 - 0.00018 20.4 0.0 0.00027 19.9 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EGD95083.1 - 0.0057 16.6 0.3 0.011 15.7 0.3 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 EGD95083.1 - 0.012 15.0 0.9 0.026 13.9 0.9 1.5 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 EGD95083.1 - 0.037 13.0 0.0 0.049 12.6 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain Endonuc_Holl PF10107.9 EGD95083.1 - 0.11 12.3 0.0 0.19 11.6 0.0 1.3 1 0 0 1 1 1 0 Endonuclease related to archaeal Holliday junction resolvase Seadorna_VP7 PF07387.11 EGD95083.1 - 0.13 11.3 0.1 0.17 10.9 0.1 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Cellulase PF00150.18 EGD95084.1 - 3.2e-09 36.6 2.8 1.1e-08 34.9 0.0 2.2 2 0 0 2 2 2 1 Cellulase (glycosyl hydrolase family 5) DUF3899 PF13038.6 EGD95084.1 - 3.8 8.1 7.6 12 6.5 0.0 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF3899) Shisa PF13908.6 EGD95085.1 - 0.00017 21.9 0.0 0.00022 21.6 0.0 1.1 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator DUF1310 PF07006.11 EGD95085.1 - 0.13 12.3 0.5 0.18 11.8 0.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1310) CD99L2 PF12301.8 EGD95085.1 - 0.24 11.7 0.1 0.24 11.7 0.1 2.0 1 1 0 2 2 2 0 CD99 antigen like protein 2 Zn_peptidase PF04228.13 EGD95085.1 - 0.26 10.7 0.2 0.36 10.2 0.2 1.1 1 0 0 1 1 1 0 Putative neutral zinc metallopeptidase Collagen PF01391.18 EGD95085.1 - 0.31 10.8 6.9 0.18 11.6 2.8 2.2 2 0 0 2 2 2 0 Collagen triple helix repeat (20 copies) Fib_alpha PF08702.10 EGD95087.1 - 0.019 15.2 3.8 0.019 15.2 3.8 4.0 1 1 4 5 5 5 0 Fibrinogen alpha/beta chain family UPF0029 PF01205.19 EGD95087.1 - 0.15 12.4 2.0 0.72 10.2 2.0 2.1 1 0 0 1 1 1 0 Uncharacterized protein family UPF0029 DivIC PF04977.15 EGD95088.1 - 0.0041 16.9 16.9 0.19 11.5 5.9 2.5 1 1 1 2 2 2 2 Septum formation initiator Fez1 PF06818.15 EGD95088.1 - 0.0077 16.7 6.2 0.0084 16.6 6.2 1.2 1 0 0 1 1 1 1 Fez1 ERM PF00769.19 EGD95088.1 - 0.0095 15.8 12.2 0.011 15.5 12.2 1.1 1 0 0 1 1 1 1 Ezrin/radixin/moesin family DUF4201 PF13870.6 EGD95088.1 - 0.011 15.5 7.0 0.016 14.9 6.2 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4201) ZapB PF06005.12 EGD95088.1 - 0.012 16.0 18.5 0.043 14.3 2.9 2.3 1 1 1 2 2 2 0 Cell division protein ZapB Phage_GP20 PF06810.11 EGD95088.1 - 0.018 14.9 11.7 0.024 14.4 11.7 1.3 1 0 0 1 1 1 0 Phage minor structural protein GP20 RelA_SpoT PF04607.17 EGD95088.1 - 0.044 14.1 0.3 0.072 13.4 0.3 1.4 1 0 0 1 1 1 0 Region found in RelA / SpoT proteins Rootletin PF15035.6 EGD95088.1 - 0.063 13.3 12.2 0.13 12.3 12.2 1.5 1 1 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion D5_N PF08706.11 EGD95088.1 - 0.069 13.4 2.8 0.11 12.8 2.8 1.3 1 0 0 1 1 1 0 D5 N terminal like YabA PF06156.13 EGD95088.1 - 0.1 13.2 8.3 1 10.0 0.5 2.4 1 1 1 2 2 2 0 Initiation control protein YabA HALZ PF02183.18 EGD95088.1 - 0.16 12.2 8.4 3.5 7.9 2.2 2.6 2 1 0 2 2 2 0 Homeobox associated leucine zipper Ribosomal_S13_N PF08069.12 EGD95088.1 - 0.21 11.6 1.1 0.76 9.9 0.2 2.2 2 0 0 2 2 2 0 Ribosomal S13/S15 N-terminal domain bZIP_1 PF00170.21 EGD95088.1 - 0.34 11.0 8.3 1.9 8.7 0.4 2.5 2 0 0 2 2 2 0 bZIP transcription factor PRKG1_interact PF15898.5 EGD95088.1 - 0.48 11.4 11.5 1.1 10.2 11.5 1.7 1 0 0 1 1 1 0 cGMP-dependent protein kinase interacting domain Hemagglutinin PF00509.18 EGD95088.1 - 0.53 8.6 4.2 0.72 8.2 4.2 1.1 1 0 0 1 1 1 0 Haemagglutinin DUF4407 PF14362.6 EGD95088.1 - 0.83 9.0 11.7 1.1 8.6 11.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) APG6_N PF17675.1 EGD95088.1 - 1 9.9 16.9 2.8 8.5 16.9 1.7 1 1 0 1 1 1 0 Apg6 coiled-coil region Atg14 PF10186.9 EGD95088.1 - 1.2 8.1 7.0 1.5 7.8 7.0 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 V_ATPase_I PF01496.19 EGD95088.1 - 2.1 6.2 6.0 2.3 6.1 6.0 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Cnn_1N PF07989.11 EGD95088.1 - 2.1 8.6 12.2 78 3.5 11.2 2.4 1 1 0 1 1 1 0 Centrosomin N-terminal motif 1 TMF_TATA_bd PF12325.8 EGD95088.1 - 2.8 8.2 12.8 4 7.7 4.8 2.3 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding CENP-H PF05837.12 EGD95088.1 - 3.6 8.0 16.3 12 6.3 6.8 2.3 1 1 1 2 2 2 0 Centromere protein H (CENP-H) HAUS-augmin3 PF14932.6 EGD95088.1 - 5.8 6.4 12.2 8 6.0 12.2 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 ATP-synt_D PF01813.17 EGD95090.1 - 0.0044 16.9 1.4 0.22 11.4 1.6 2.2 2 0 0 2 2 2 2 ATP synthase subunit D HTH_37 PF13744.6 EGD95090.1 - 0.045 13.7 1.1 0.14 12.1 0.4 2.2 2 0 0 2 2 2 0 Helix-turn-helix domain Med13_C PF06333.12 EGD95091.1 - 9.1e-77 258.5 8.1 9.1e-77 258.5 8.1 1.8 2 0 0 2 2 2 1 Mediator complex subunit 13 C-terminal domain Med13_N PF11597.8 EGD95091.1 - 4.4e-41 141.3 1.9 4.4e-41 141.3 1.9 2.3 2 0 0 2 2 2 1 Mediator complex subunit 13 N-terminal MID_MedPIWI PF18296.1 EGD95091.1 - 5.4e-24 85.3 8.8 3e-22 79.6 0.3 3.9 3 1 0 3 3 3 1 MID domain of medPIWI NUC153 PF08159.12 EGD95092.1 - 4.7e-10 39.1 1.1 1.1e-09 38.0 1.1 1.6 1 0 0 1 1 1 1 NUC153 domain WD40 PF00400.32 EGD95092.1 - 8.3e-05 23.3 0.0 8.5 7.4 0.0 5.0 5 0 0 5 5 5 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EGD95092.1 - 0.01 16.1 0.0 0.067 13.5 0.0 2.3 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain Sulfotransfer_4 PF17784.1 EGD95093.1 - 7.7e-74 248.1 0.0 9.4e-74 247.9 0.0 1.1 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 EGD95093.1 - 0.00016 22.2 0.4 0.016 15.6 0.0 2.5 1 1 1 2 2 2 2 Sulfotransferase family Lipase3_N PF03893.16 EGD95093.1 - 0.11 12.5 0.1 4.5 7.4 0.0 2.7 3 0 0 3 3 3 0 Lipase 3 N-terminal region SET PF00856.28 EGD95094.1 - 9.3e-15 55.4 1.3 5.1e-14 53.0 0.0 2.8 2 2 0 2 2 2 1 SET domain TPR_8 PF13181.6 EGD95094.1 - 0.00056 19.9 0.7 0.0091 16.1 0.1 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 EGD95094.1 - 0.00088 19.2 4.9 0.042 14.0 0.3 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 EGD95094.1 - 0.0014 18.9 1.8 0.0041 17.4 1.8 1.8 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_14 PF13428.6 EGD95094.1 - 0.0038 17.9 0.0 0.029 15.2 0.0 2.6 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_1 PF00515.28 EGD95094.1 - 0.017 14.9 3.2 0.33 10.8 0.1 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat PDZ_6 PF17820.1 EGD95094.1 - 0.048 13.5 0.0 14 5.6 0.0 2.9 3 0 0 3 3 3 0 PDZ domain TPR_16 PF13432.6 EGD95094.1 - 0.23 12.1 3.9 1.9 9.2 0.1 2.6 1 1 1 2 2 2 0 Tetratricopeptide repeat FAD_binding_4 PF01565.23 EGD95095.1 - 1e-26 93.3 0.5 2e-26 92.4 0.5 1.5 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EGD95095.1 - 4.8e-05 23.4 0.0 0.0001 22.3 0.0 1.6 1 0 0 1 1 1 1 Berberine and berberine like ATG13 PF10033.9 EGD95096.1 - 5.9e-67 225.9 0.0 8.7e-67 225.3 0.0 1.3 1 0 0 1 1 1 1 Autophagy-related protein 13 RCC1 PF00415.18 EGD95098.1 - 7.5e-25 87.3 0.1 6.2e-07 29.9 0.0 5.4 5 0 0 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat BTB PF00651.31 EGD95098.1 - 1.3e-13 51.1 0.2 7.5e-08 32.6 0.0 2.5 2 0 0 2 2 2 2 BTB/POZ domain RCC1_2 PF13540.6 EGD95098.1 - 4.7e-10 39.0 4.5 9.1e-09 34.9 0.1 4.1 5 0 0 5 5 5 1 Regulator of chromosome condensation (RCC1) repeat Ank_4 PF13637.6 EGD95098.1 - 8e-06 26.3 0.1 0.00022 21.7 0.0 2.5 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_5 PF13857.6 EGD95098.1 - 0.0032 17.7 0.0 0.082 13.3 0.0 2.5 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 EGD95098.1 - 0.0081 16.7 0.0 0.018 15.6 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EGD95098.1 - 0.016 15.7 0.1 2 9.3 0.0 3.0 2 0 0 2 2 2 0 Ankyrin repeat TCO89 PF10452.9 EGD95099.1 - 0.021 13.9 17.4 0.076 12.0 0.0 3.4 2 2 0 2 2 2 0 TORC1 subunit TCO89 PBP1_TM PF14812.6 EGD95099.1 - 0.19 12.1 4.5 2.5 8.5 0.3 2.8 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal VHS PF00790.19 EGD95100.1 - 2e-42 144.4 3.1 7.9e-42 142.5 0.4 2.4 2 0 0 2 2 2 1 VHS domain FYVE PF01363.21 EGD95100.1 - 8.4e-16 57.9 1.8 1.5e-15 57.1 1.8 1.4 1 0 0 1 1 1 1 FYVE zinc finger UIM PF02809.20 EGD95100.1 - 9.5e-07 28.3 10.5 0.0014 18.4 1.9 2.6 2 0 0 2 2 2 2 Ubiquitin interaction motif GAT PF03127.14 EGD95100.1 - 3.6e-06 27.2 0.3 2.5e-05 24.5 0.0 2.4 2 0 0 2 2 2 1 GAT domain Npa1 PF11707.8 EGD95100.1 - 0.016 14.6 0.2 0.038 13.3 0.2 1.6 1 1 0 1 1 1 0 Ribosome 60S biogenesis N-terminal DUF753 PF05444.12 EGD95100.1 - 0.059 13.4 1.2 0.099 12.6 1.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF753) FYVE_2 PF02318.16 EGD95100.1 - 0.069 13.4 0.3 0.17 12.1 0.3 1.6 1 0 0 1 1 1 0 FYVE-type zinc finger OrfB_Zn_ribbon PF07282.11 EGD95100.1 - 1.8 8.6 5.2 1.7 8.7 3.6 1.7 2 0 0 2 2 2 0 Putative transposase DNA-binding domain Fer4_2 PF12797.7 EGD95100.1 - 3.5 7.9 4.3 2.2 8.6 0.2 2.3 2 0 0 2 2 2 0 4Fe-4S binding domain UCH PF00443.29 EGD95101.1 - 3e-53 180.9 0.1 4.5e-53 180.4 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EGD95101.1 - 1.9e-17 63.8 0.6 2.2e-14 53.8 0.2 2.2 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase Rhodanese PF00581.20 EGD95101.1 - 0.00014 22.3 0.0 0.00035 21.1 0.0 1.7 1 0 0 1 1 1 1 Rhodanese-like domain HSP70 PF00012.20 EGD95102.1 - 1.3e-259 862.5 12.9 1.5e-259 862.3 12.9 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EGD95102.1 - 2.8e-19 69.1 0.8 5.5e-18 64.9 0.4 2.1 2 0 0 2 2 2 1 MreB/Mbl protein DDR PF08841.10 EGD95102.1 - 0.0024 16.9 0.5 0.03 13.3 0.4 2.2 2 0 0 2 2 2 1 Diol dehydratase reactivase ATPase-like domain Hydantoinase_A PF01968.18 EGD95102.1 - 0.01 15.1 1.6 0.95 8.7 0.2 2.9 3 0 0 3 3 3 0 Hydantoinase/oxoprolinase BcrAD_BadFG PF01869.20 EGD95102.1 - 0.016 14.7 0.1 0.74 9.3 0.0 2.6 2 0 0 2 2 2 0 BadF/BadG/BcrA/BcrD ATPase family FGGY_C PF02782.16 EGD95102.1 - 0.089 12.5 0.0 0.23 11.1 0.0 1.7 2 0 0 2 2 2 0 FGGY family of carbohydrate kinases, C-terminal domain StbA PF06406.11 EGD95102.1 - 0.21 10.8 2.9 0.9 8.7 0.6 2.6 2 1 0 2 2 2 0 StbA protein FtsA PF14450.6 EGD95102.1 - 0.65 10.5 8.0 8.4 6.9 0.2 3.5 3 2 0 3 3 3 0 Cell division protein FtsA FIVAR PF07554.13 EGD95102.1 - 2 9.2 8.9 3.3 8.5 1.2 3.8 4 0 0 4 4 4 0 FIVAR domain GTP_EFTU PF00009.27 EGD95103.1 - 1e-49 168.8 0.0 1.9e-49 167.9 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain HBS1_N PF08938.10 EGD95103.1 - 2.1e-19 69.6 8.1 4.3e-19 68.6 8.1 1.5 1 0 0 1 1 1 1 HBS1 N-terminus GTP_EFTU_D3 PF03143.17 EGD95103.1 - 7.8e-09 35.8 0.1 2.9e-08 34.0 0.0 2.2 2 0 0 2 2 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 EGD95103.1 - 1.1e-07 32.2 0.0 4.6e-07 30.1 0.0 2.1 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EGD95103.1 - 1.3e-07 31.7 0.0 3.2e-06 27.2 0.0 2.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase Arf PF00025.21 EGD95103.1 - 0.00014 21.4 0.1 0.034 13.6 0.0 2.4 1 1 1 2 2 2 2 ADP-ribosylation factor family Ras PF00071.22 EGD95103.1 - 0.00099 18.7 0.2 0.019 14.5 0.0 2.3 1 1 1 2 2 2 1 Ras family FeoB_N PF02421.18 EGD95103.1 - 0.0011 18.5 0.1 0.057 12.9 0.2 3.1 2 1 0 2 2 2 1 Ferrous iron transport protein B SRPRB PF09439.10 EGD95103.1 - 0.0032 16.9 0.1 0.43 10.0 0.1 2.5 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit RsgA_GTPase PF03193.16 EGD95103.1 - 0.0045 16.9 0.4 0.56 10.1 0.2 2.5 2 0 0 2 2 2 1 RsgA GTPase Gtr1_RagA PF04670.12 EGD95103.1 - 0.0065 15.9 0.1 0.013 14.9 0.1 1.5 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region Roc PF08477.13 EGD95103.1 - 0.0098 16.1 0.1 3.3 8.0 0.0 2.6 1 1 1 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 EGD95103.1 - 0.058 12.5 0.5 0.97 8.5 0.0 2.5 3 0 0 3 3 3 0 G-protein alpha subunit Cyt-b5 PF00173.28 EGD95104.1 - 5.7e-24 84.1 0.1 7.4e-24 83.7 0.1 1.1 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain K_trans PF02705.16 EGD95105.1 - 3.7e-185 616.5 17.3 4.3e-185 616.2 17.3 1.0 1 0 0 1 1 1 1 K+ potassium transporter VHS PF00790.19 EGD95106.1 - 1.6e-36 125.2 1.5 2.8e-36 124.5 1.5 1.4 1 0 0 1 1 1 1 VHS domain SH3_1 PF00018.28 EGD95106.1 - 1.1e-17 63.4 0.1 7.5e-17 60.7 0.0 2.2 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 EGD95106.1 - 3e-15 55.8 0.1 6e-15 54.8 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EGD95106.1 - 3.8e-13 48.9 0.1 1.1e-12 47.5 0.0 1.8 2 0 0 2 2 2 1 Variant SH3 domain GAT PF03127.14 EGD95106.1 - 4.2e-10 39.8 1.5 4.2e-10 39.8 1.5 2.4 2 1 0 2 2 2 1 GAT domain DUF4598 PF15370.6 EGD95106.1 - 0.0023 18.4 1.2 0.0061 17.0 1.2 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4598) UIM PF02809.20 EGD95106.1 - 0.022 14.7 1.4 0.052 13.5 1.4 1.7 1 0 0 1 1 1 0 Ubiquitin interaction motif DUF3361 PF11841.8 EGD95106.1 - 0.54 10.2 2.3 0.44 10.5 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3361) CemA PF03040.14 EGD95106.1 - 7.5 6.4 5.2 4.4 7.2 0.2 2.2 2 1 0 2 2 2 0 CemA family Pkinase PF00069.25 EGD95107.1 - 1e-64 218.5 0.1 2.1e-64 217.5 0.1 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD95107.1 - 5.6e-43 147.1 0.8 8e-43 146.6 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase PBD PF00786.28 EGD95107.1 - 1.7e-21 76.3 0.4 1.7e-21 76.3 0.4 2.2 2 0 0 2 2 2 1 P21-Rho-binding domain Pkinase_fungal PF17667.1 EGD95107.1 - 4.1e-07 29.1 0.8 2e-06 26.9 0.0 2.2 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 EGD95107.1 - 2e-06 27.3 0.0 3.8e-06 26.4 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 EGD95107.1 - 0.03 13.7 1.0 0.046 13.1 0.2 1.7 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EGD95107.1 - 0.042 13.8 0.1 0.55 10.1 0.1 2.3 1 1 1 2 2 2 0 Phosphotransferase enzyme family DSHCT PF08148.12 EGD95107.1 - 0.054 13.2 0.6 0.14 11.8 0.0 1.9 2 0 0 2 2 2 0 DSHCT (NUC185) domain FTA2 PF13095.6 EGD95107.1 - 0.43 10.2 0.0 0.43 10.2 0.0 2.0 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Haspin_kinase PF12330.8 EGD95107.1 - 8.7 5.2 8.7 0.4 9.6 1.3 2.3 2 1 0 2 2 2 0 Haspin like kinase domain KH_1 PF00013.29 EGD95108.1 - 5.8e-99 324.0 12.4 1.5e-12 47.2 0.3 13.8 13 2 0 13 13 13 9 KH domain SLS PF14611.6 EGD95108.1 - 2.2e-11 44.0 0.0 0.14 12.0 0.0 7.0 3 3 6 9 9 9 5 Mitochondrial inner-membrane-bound regulator KH_2 PF07650.17 EGD95108.1 - 1.9e-09 37.2 19.0 0.0033 17.2 0.2 8.3 9 0 0 9 9 9 3 KH domain KH_4 PF13083.6 EGD95108.1 - 0.00052 19.8 4.8 19 5.2 0.1 6.0 7 0 0 7 7 7 1 KH domain KH_5 PF13184.6 EGD95108.1 - 0.67 10.1 9.2 38 4.5 0.3 5.7 6 0 0 6 6 6 0 NusA-like KH domain BMC PF00936.19 EGD95108.1 - 2.1 8.4 7.8 1.7 8.7 0.2 4.1 5 0 0 5 5 5 0 BMC domain UCH_1 PF13423.6 EGD95109.1 - 3.7e-96 322.5 0.6 4.9e-96 322.1 0.6 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase RNase_T PF00929.24 EGD95109.1 - 3.6e-14 53.6 0.0 3.8e-13 50.3 0.0 2.5 2 0 0 2 2 2 1 Exonuclease UCH PF00443.29 EGD95109.1 - 0.0027 17.2 0.0 0.011 15.2 0.0 1.9 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase DUF3632 PF12311.8 EGD95110.1 - 4e-14 53.4 0.0 7e-13 49.4 0.0 2.6 2 1 0 2 2 2 1 Protein of unknown function (DUF3632) MSC PF09402.10 EGD95111.1 - 7.4e-105 351.1 0.0 1e-104 350.6 0.0 1.2 1 0 0 1 1 1 1 Man1-Src1p-C-terminal domain HeH PF12949.7 EGD95111.1 - 2.9e-16 58.9 0.1 5.7e-16 57.9 0.1 1.5 1 0 0 1 1 1 1 HeH/LEM domain PP2C PF00481.21 EGD95112.1 - 3.1e-53 181.1 0.0 4.4e-53 180.5 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C LRR_8 PF13855.6 EGD95112.1 - 7.8e-41 137.7 63.9 1.3e-11 44.0 7.7 11.0 7 3 6 13 13 13 10 Leucine rich repeat LRR_4 PF12799.7 EGD95112.1 - 7.2e-37 124.8 67.0 2.4e-06 27.8 2.2 12.4 7 2 7 14 14 14 13 Leucine Rich repeats (2 copies) Guanylate_cyc PF00211.20 EGD95112.1 - 3.9e-27 95.1 0.0 2.6e-26 92.4 0.0 2.0 2 0 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain LRR_9 PF14580.6 EGD95112.1 - 7.7e-09 35.3 16.4 0.0043 16.6 1.1 4.8 2 1 3 5 5 5 5 Leucine-rich repeat Ad_cyc_g-alpha PF08509.11 EGD95112.1 - 1.4e-08 34.3 0.1 6.4e-08 32.2 0.1 2.2 1 0 0 1 1 1 1 Adenylate cyclase G-alpha binding domain LRR_1 PF00560.33 EGD95112.1 - 6.5e-08 32.1 61.1 2.1 9.2 0.1 15.8 16 2 0 16 16 16 5 Leucine Rich Repeat LRR_5 PF13306.6 EGD95112.1 - 7.7e-06 25.9 4.7 0.057 13.4 0.2 4.0 3 1 0 4 4 4 2 BspA type Leucine rich repeat region (6 copies) LRR_6 PF13516.6 EGD95112.1 - 0.00049 19.9 48.2 4.3 7.7 0.3 13.4 15 0 0 15 15 15 4 Leucine Rich repeat RA PF00788.23 EGD95112.1 - 0.059 14.0 0.0 0.13 12.9 0.0 1.6 1 0 0 1 1 1 0 Ras association (RalGDS/AF-6) domain tRNA-synt_1b PF00579.25 EGD95113.1 - 2.6e-66 223.9 0.0 3.2e-66 223.6 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) Pkinase PF00069.25 EGD95116.1 - 7.6e-08 32.0 0.0 1.1e-07 31.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD95116.1 - 0.013 14.8 0.0 0.018 14.3 0.0 1.2 1 0 0 1 1 1 0 Protein tyrosine kinase Kdo PF06293.14 EGD95116.1 - 0.16 11.3 0.0 0.35 10.2 0.0 1.7 2 1 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Glyco_hydro_16 PF00722.21 EGD95117.1 - 1.9e-43 148.0 0.1 1.9e-43 148.0 0.1 1.5 2 0 0 2 2 2 1 Glycosyl hydrolases family 16 Laminin_G_3 PF13385.6 EGD95117.1 - 0.0039 17.4 0.2 0.0039 17.4 0.2 1.9 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily MFS_1 PF07690.16 EGD95118.1 - 1.2e-35 123.0 25.4 1.2e-35 123.0 25.4 1.3 2 0 0 2 2 2 1 Major Facilitator Superfamily S4 PF01479.25 EGD95120.1 - 2e-11 43.4 0.0 3.2e-11 42.7 0.0 1.4 1 0 0 1 1 1 1 S4 domain Ribosomal_S4 PF00163.19 EGD95120.1 - 1.2e-10 42.2 2.7 1.5e-10 41.8 2.1 1.5 1 1 0 1 1 1 1 Ribosomal protein S4/S9 N-terminal domain PilP PF04351.13 EGD95120.1 - 0.031 14.2 0.0 0.058 13.3 0.0 1.6 2 0 0 2 2 2 0 Pilus assembly protein, PilP ADH_zinc_N PF00107.26 EGD95121.1 - 6.2e-08 32.7 0.0 1.2e-07 31.8 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Lsm_interact PF05391.11 EGD95123.1 - 0.013 14.9 0.3 0.025 14.1 0.3 1.5 1 0 0 1 1 1 0 Lsm interaction motif baeRF_family12 PF18856.1 EGD95124.1 - 0.037 14.6 0.0 0.06 13.9 0.0 1.2 1 0 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 12 DUF1206 PF06724.11 EGD95124.1 - 0.15 12.2 0.1 0.24 11.5 0.1 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1206) DnaJ PF00226.31 EGD95125.1 - 1.7e-23 82.5 2.4 2.8e-23 81.8 2.4 1.4 1 0 0 1 1 1 1 DnaJ domain DnaJ_C PF01556.18 EGD95125.1 - 2.4e-19 69.9 0.0 3.6e-19 69.3 0.0 1.3 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.19 EGD95125.1 - 1.7e-13 50.7 16.8 2.7e-13 50.0 16.8 1.4 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 EGD95125.1 - 0.0005 20.0 8.3 0.12 12.4 1.7 2.4 2 0 0 2 2 2 2 Tryptophan RNA-binding attenuator protein inhibitory protein HypA PF01155.19 EGD95125.1 - 0.064 13.3 6.9 2.1 8.4 1.1 2.2 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DUF4449 PF14613.6 EGD95126.1 - 1e-05 25.7 5.2 0.00011 22.3 0.1 2.9 2 0 0 2 2 2 1 Protein of unknown function (DUF4449) Ku_PK_bind PF08785.11 EGD95126.1 - 0.0067 16.6 0.3 0.15 12.2 0.0 3.1 3 0 0 3 3 3 1 Ku C terminal domain like Maelstrom PF13017.6 EGD95126.1 - 0.057 13.1 0.1 1.1 8.9 0.0 2.3 2 0 0 2 2 2 0 piRNA pathway germ-plasm component Kinesin PF00225.23 EGD95127.1 - 1.9e-25 89.5 0.1 2.7e-25 89.0 0.1 1.2 1 0 0 1 1 1 1 Kinesin motor domain SAM_PNT PF02198.16 EGD95127.1 - 0.066 13.2 0.0 0.14 12.2 0.0 1.5 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain Malic_M PF03949.15 EGD95128.1 - 4.8e-92 307.9 0.0 6.6e-92 307.4 0.0 1.2 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.19 EGD95128.1 - 2.9e-64 216.2 0.0 4.9e-64 215.5 0.0 1.3 1 0 0 1 1 1 1 Malic enzyme, N-terminal domain PTR2 PF00854.21 EGD95129.1 - 1.5e-95 320.4 10.6 4.5e-95 318.8 10.6 1.7 1 1 0 1 1 1 1 POT family THOC7 PF05615.13 EGD95130.1 - 1.1e-44 152.0 8.5 1.1e-44 152.0 8.5 2.3 1 1 1 2 2 2 1 Tho complex subunit 7 CCDC92 PF14916.6 EGD95130.1 - 0.0025 17.6 0.2 0.0071 16.1 0.2 1.7 1 0 0 1 1 1 1 Coiled-coil domain of unknown function DUF1843 PF08898.10 EGD95130.1 - 0.031 14.8 2.2 0.032 14.7 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1843) Peroxin-13_N PF04088.13 EGD95130.1 - 0.067 13.5 0.1 0.16 12.3 0.1 1.7 1 0 0 1 1 1 0 Peroxin 13, N-terminal region LMBR1 PF04791.16 EGD95130.1 - 3 6.6 7.3 3.8 6.3 7.3 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein FUSC PF04632.12 EGD95130.1 - 9.4 4.6 10.8 9 4.7 9.4 1.3 1 1 0 1 1 1 0 Fusaric acid resistance protein family TBCA PF02970.16 EGD95131.1 - 8.5e-22 77.3 9.3 1.6e-21 76.4 8.9 1.7 1 1 0 1 1 1 1 Tubulin binding cofactor A AdoMet_Synthase PF01941.19 EGD95131.1 - 0.028 13.2 0.0 0.051 12.4 0.0 1.4 1 0 0 1 1 1 0 S-adenosylmethionine synthetase (AdoMet synthetase) FIVAR PF07554.13 EGD95131.1 - 0.033 14.9 1.1 0.033 14.9 1.1 2.0 2 0 0 2 2 2 0 FIVAR domain DUF948 PF06103.11 EGD95131.1 - 0.05 13.9 0.7 0.072 13.4 0.1 1.5 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) AAA_23 PF13476.6 EGD95131.1 - 0.1 13.1 4.3 0.15 12.6 4.3 1.3 1 0 0 1 1 1 0 AAA domain Bacillus_HBL PF05791.11 EGD95131.1 - 0.25 11.1 3.5 0.27 11.0 0.1 1.9 2 0 0 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) Dynamin_M PF01031.20 EGD95131.1 - 0.28 10.4 4.5 0.21 10.8 0.2 2.0 2 0 0 2 2 2 0 Dynamin central region APG6_N PF17675.1 EGD95131.1 - 0.4 11.2 14.3 1.3 9.6 14.3 1.7 1 1 0 1 1 1 0 Apg6 coiled-coil region TMF_DNA_bd PF12329.8 EGD95131.1 - 2.4 8.2 14.5 1.4 8.9 2.0 2.5 2 1 0 2 2 2 0 TATA element modulatory factor 1 DNA binding DUF2203 PF09969.9 EGD95131.1 - 4.6 8.0 7.6 5.3 7.8 2.0 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) Spc24 PF08286.11 EGD95131.1 - 9.7 6.5 8.9 2.2 8.6 1.4 2.1 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 Band_7 PF01145.25 EGD95133.1 - 3.8e-16 59.6 0.0 3.8e-16 59.6 0.0 2.7 2 1 0 2 2 2 1 SPFH domain / Band 7 family Sugar_tr PF00083.24 EGD95134.1 - 1.5e-84 284.4 23.1 1.7e-84 284.3 23.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EGD95134.1 - 1e-15 57.6 34.4 4.1e-12 45.7 19.7 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily EBP PF05241.12 EGD95134.1 - 1.2 8.6 11.3 0.38 10.2 4.2 2.5 2 1 0 2 2 2 0 Emopamil binding protein HERV-K_REC PF15695.5 EGD95135.1 - 0.045 13.8 2.8 0.075 13.1 0.2 2.4 2 1 1 3 3 3 0 Rec (regulator of expression encoded by corf) of HERV-K-113 DUF4611 PF15387.6 EGD95135.1 - 0.064 13.5 3.2 0.098 12.9 3.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) F-box-like PF12937.7 EGD95136.1 - 0.011 15.6 0.0 0.028 14.3 0.0 1.7 1 0 0 1 1 1 0 F-box-like F-box PF00646.33 EGD95136.1 - 0.02 14.8 0.0 0.06 13.2 0.0 1.8 1 0 0 1 1 1 0 F-box domain Stc1 PF12898.7 EGD95136.1 - 0.038 14.5 2.0 0.14 12.8 0.5 2.3 2 0 0 2 2 2 0 Stc1 domain zf-C2HCIx2C PF10782.9 EGD95136.1 - 3 7.8 5.9 1.2 9.1 3.1 1.8 2 0 0 2 2 2 0 Zinc-finger Elongin_A PF06881.11 EGD95137.1 - 3.2e-28 98.3 1.6 5.7e-28 97.5 1.6 1.4 1 0 0 1 1 1 1 RNA polymerase II transcription factor SIII (Elongin) subunit A Sfi1 PF08457.10 EGD95138.1 - 2.2e-197 657.1 89.4 3.7e-196 653.1 78.9 2.1 1 1 1 2 2 2 2 Sfi1 spindle body protein IZUMO PF15005.6 EGD95138.1 - 0.07 13.7 1.2 0.45 11.0 1.2 2.4 1 0 0 1 1 1 0 Izumo sperm-egg fusion, Ig domain-associated Alpha_kinase PF02816.18 EGD95138.1 - 8 6.5 6.3 0.74 9.9 0.1 2.4 3 0 0 3 3 3 0 Alpha-kinase family p450 PF00067.22 EGD95139.1 - 3.6e-74 250.2 0.0 5.6e-74 249.6 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 FAD_binding_1 PF00667.20 EGD95139.1 - 4.2e-27 95.2 0.0 6.8e-27 94.5 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 EGD95139.1 - 3.2e-21 76.0 0.0 7.3e-21 74.9 0.0 1.7 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.21 EGD95139.1 - 2.2e-11 44.4 0.0 4.8e-11 43.3 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Flavodoxin_5 PF12724.7 EGD95139.1 - 0.00099 19.4 0.0 0.0022 18.3 0.0 1.5 1 0 0 1 1 1 1 Flavodoxin domain tRNA-synt_1 PF00133.22 EGD95140.1 - 3.6e-223 742.2 0.0 5e-223 741.7 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 EGD95140.1 - 7e-24 84.5 0.0 2.1e-23 82.9 0.0 1.8 2 0 0 2 2 2 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 EGD95140.1 - 2.2e-13 49.7 0.0 9.9e-06 24.5 0.0 4.1 3 1 0 3 3 3 3 tRNA synthetases class I (M) tRNA-synt_1e PF01406.19 EGD95140.1 - 0.078 12.3 0.0 1.2 8.5 0.0 2.3 2 0 0 2 2 2 0 tRNA synthetases class I (C) catalytic domain Uso1_p115_head PF04869.14 EGD95141.1 - 5.1e-111 370.8 0.2 5.4e-110 367.4 0.0 2.6 3 0 0 3 3 3 1 Uso1 / p115 like vesicle tethering protein, head region Uso1_p115_C PF04871.13 EGD95141.1 - 6.2e-17 62.1 41.8 6.2e-17 62.1 41.8 3.4 1 1 2 3 3 3 1 Uso1 / p115 like vesicle tethering protein, C terminal region DUF2570 PF10828.8 EGD95141.1 - 0.5 10.2 28.9 0.13 12.1 7.2 3.9 2 1 2 4 4 4 0 Protein of unknown function (DUF2570) Filament PF00038.21 EGD95141.1 - 1.5 8.4 50.4 3.1 7.3 50.2 1.6 1 1 0 1 1 1 0 Intermediate filament protein UPF0227 PF05728.12 EGD95141.1 - 9.3 6.1 8.7 7.2 6.5 1.0 2.4 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0227) XRN_M PF17846.1 EGD95142.1 - 1.8e-153 511.7 0.1 1.8e-153 511.7 0.1 1.8 2 1 0 2 2 2 1 Xrn1 helical domain XRN_N PF03159.18 EGD95142.1 - 6.5e-93 310.6 1.6 2.9e-91 305.2 0.0 3.4 3 1 0 3 3 3 1 XRN 5'-3' exonuclease N-terminus EPSP_synthase PF00275.20 EGD95143.1 - 1.8e-131 438.7 0.0 5e-131 437.2 0.0 1.7 2 0 0 2 2 2 1 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) DHQ_synthase PF01761.20 EGD95143.1 - 6.5e-98 327.1 0.0 1.1e-97 326.3 0.0 1.4 1 0 0 1 1 1 1 3-dehydroquinate synthase DHquinase_I PF01487.15 EGD95143.1 - 1.9e-55 188.7 0.0 4.5e-55 187.4 0.0 1.7 1 0 0 1 1 1 1 Type I 3-dehydroquinase SKI PF01202.22 EGD95143.1 - 4.1e-36 124.5 0.0 8.7e-36 123.4 0.0 1.6 1 0 0 1 1 1 1 Shikimate kinase Shikimate_dh_N PF08501.11 EGD95143.1 - 7.1e-26 90.3 0.0 2.1e-25 88.8 0.0 1.9 1 0 0 1 1 1 1 Shikimate dehydrogenase substrate binding domain SDH_C PF18317.1 EGD95143.1 - 1.4e-07 31.1 1.2 3.3e-07 29.9 0.3 2.1 2 0 0 2 2 2 1 Shikimate 5'-dehydrogenase C-terminal domain Fe-ADH_2 PF13685.6 EGD95143.1 - 4.9e-07 29.7 0.0 1.3e-06 28.3 0.0 1.7 1 1 0 1 1 1 1 Iron-containing alcohol dehydrogenase Shikimate_DH PF01488.20 EGD95143.1 - 3.9e-05 23.7 0.0 0.00011 22.3 0.0 1.7 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase AAA_24 PF13479.6 EGD95143.1 - 0.00086 19.1 0.0 0.0026 17.5 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EGD95143.1 - 0.053 13.7 0.0 0.12 12.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 EGD95143.1 - 0.12 12.9 0.1 0.31 11.6 0.1 1.7 1 0 0 1 1 1 0 AAA domain PPR_2 PF13041.6 EGD95144.1 - 9.7e-25 86.5 0.0 5.2e-17 61.8 0.0 3.0 3 0 0 3 3 3 2 PPR repeat family PPR_3 PF13812.6 EGD95144.1 - 1.2e-09 38.1 0.0 0.00013 21.9 0.0 2.8 2 0 0 2 2 2 2 Pentatricopeptide repeat domain PPR_1 PF12854.7 EGD95144.1 - 8.6e-07 28.5 0.0 0.27 11.0 0.0 3.8 3 0 0 3 3 3 3 PPR repeat PPR PF01535.20 EGD95144.1 - 2e-05 24.5 5.3 8.4e-05 22.6 0.0 4.0 5 0 0 5 5 5 1 PPR repeat PPR_long PF17177.4 EGD95144.1 - 0.018 14.4 0.0 0.063 12.6 0.0 1.9 1 1 0 1 1 1 0 Pentacotripeptide-repeat region of PRORP Cas_Cmr3 PF09700.10 EGD95144.1 - 0.21 11.0 1.2 0.66 9.3 0.6 1.9 2 0 0 2 2 2 0 CRISPR-associated protein (Cas_Cmr3) FAM176 PF14851.6 EGD95144.1 - 1.9 8.1 9.5 1.2 8.8 4.7 2.7 3 0 0 3 3 3 0 FAM176 family DEAD PF00270.29 EGD95145.1 - 1.3e-50 171.6 0.0 2.4e-49 167.5 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.15 EGD95145.1 - 4e-05 23.7 0.0 0.00014 21.9 0.0 1.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EGD95145.1 - 0.00015 22.1 0.0 0.00084 19.7 0.0 2.1 1 1 1 2 2 2 1 Helicase conserved C-terminal domain AAA_19 PF13245.6 EGD95145.1 - 0.012 15.9 0.0 5.2 7.4 0.0 2.4 2 1 0 2 2 2 0 AAA domain DUF5335 PF17269.2 EGD95145.1 - 0.017 14.9 0.1 0.03 14.2 0.1 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5335) DUF2443 PF10398.9 EGD95145.1 - 0.064 13.3 0.4 0.14 12.2 0.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2443) DUF445 PF04286.12 EGD95145.1 - 0.076 12.8 0.1 0.11 12.3 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF445) AAA_22 PF13401.6 EGD95145.1 - 0.2 11.9 2.4 11 6.3 0.0 3.0 2 1 0 3 3 3 0 AAA domain Phos_pyr_kin PF08543.12 EGD95146.1 - 5.4e-62 209.4 0.3 1.1e-57 195.3 0.5 2.2 1 1 0 2 2 2 2 Phosphomethylpyrimidine kinase TENA_THI-4 PF03070.16 EGD95146.1 - 8.9e-43 146.5 0.2 1.6e-42 145.7 0.2 1.4 1 0 0 1 1 1 1 TENA/THI-4/PQQC family PfkB PF00294.24 EGD95146.1 - 3.1e-05 23.4 0.0 4.9e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Paramyxo_C PF01692.18 EGD95147.1 - 0.13 11.7 0.2 0.25 10.7 0.2 1.5 1 0 0 1 1 1 0 Paramyxovirus non-structural protein C zf-C2H2 PF00096.26 EGD95147.1 - 0.38 11.3 1.4 0.46 11.0 0.2 1.8 2 0 0 2 2 2 0 Zinc finger, C2H2 type Ribosomal_60s PF00428.19 EGD95151.1 - 0.31 11.7 5.3 0.38 11.4 5.3 1.2 1 0 0 1 1 1 0 60s Acidic ribosomal protein Sds3 PF08598.11 EGD95154.1 - 4.9e-47 160.7 8.2 4.4e-46 157.6 2.4 2.2 1 1 1 2 2 2 2 Sds3-like Collagen PF01391.18 EGD95156.1 - 1.1e-16 60.3 96.9 6.6e-10 38.6 46.4 5.1 4 2 1 5 5 5 2 Collagen triple helix repeat (20 copies) CFEM PF05730.11 EGD95156.1 - 1e-05 25.6 0.9 1e-05 25.6 0.9 2.6 3 0 0 3 3 3 1 CFEM domain Pro-rich PF15240.6 EGD95160.1 - 0.17 12.2 6.9 0.33 11.2 6.9 1.5 1 1 0 1 1 1 0 Proline-rich PilO PF04350.13 EGD95161.1 - 0.016 15.4 1.1 0.039 14.1 0.3 2.0 1 1 1 2 2 2 0 Pilus assembly protein, PilO Baculo_PEP_C PF04513.12 EGD95161.1 - 0.019 15.0 0.7 0.019 15.0 0.7 2.1 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Med3 PF11593.8 EGD95161.1 - 0.16 11.1 15.9 0.13 11.4 8.1 2.4 2 0 0 2 2 2 0 Mediator complex subunit 3 fungal DUF2752 PF10825.8 EGD95161.1 - 0.29 11.2 1.1 0.49 10.5 1.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2752) DUF148 PF02520.17 EGD95161.1 - 2.4 8.3 6.6 0.17 12.0 0.9 2.0 2 0 0 2 2 2 0 Domain of unknown function DUF148 RCC1 PF00415.18 EGD95162.1 - 8e-48 160.9 10.1 4.7e-11 43.1 0.0 8.3 7 1 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EGD95162.1 - 6.4e-36 121.4 28.6 1.7e-07 30.8 1.4 6.7 7 0 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat p450 PF00067.22 EGD95163.1 - 8.3e-28 97.3 0.0 1.3e-27 96.7 0.0 1.3 1 0 0 1 1 1 1 Cytochrome P450 Sterol_MT_C PF08498.10 EGD95164.1 - 1.9e-23 82.6 0.1 3.4e-23 81.7 0.1 1.4 1 0 0 1 1 1 1 Sterol methyltransferase C-terminal Methyltransf_11 PF08241.12 EGD95164.1 - 9.8e-20 71.0 0.0 1.7e-19 70.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EGD95164.1 - 1.3e-18 67.2 0.0 1.8e-18 66.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EGD95164.1 - 2.2e-18 66.7 0.0 4.2e-18 65.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EGD95164.1 - 1.1e-13 51.1 0.0 1.8e-13 50.4 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family CMAS PF02353.20 EGD95164.1 - 5.4e-13 48.9 0.0 7.3e-13 48.4 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_23 PF13489.6 EGD95164.1 - 6.3e-13 48.9 0.0 9.9e-13 48.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EGD95164.1 - 4.4e-10 40.2 0.0 9.2e-10 39.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 EGD95164.1 - 1.3e-06 28.3 0.0 2.2e-06 27.6 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) PrmA PF06325.13 EGD95164.1 - 0.0027 17.2 0.0 0.0043 16.5 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MetW PF07021.12 EGD95164.1 - 0.0052 16.4 0.0 0.0084 15.7 0.0 1.3 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW MTS PF05175.14 EGD95164.1 - 0.0096 15.5 0.0 0.016 14.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_15 PF09445.10 EGD95164.1 - 0.065 12.8 0.0 0.083 12.5 0.0 1.2 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase DRE2_N PF16803.5 EGD95164.1 - 0.088 13.1 0.0 0.21 11.8 0.0 1.6 1 0 0 1 1 1 0 Fe-S cluster assembly protein DRE2 N-terminus Methyltransf_32 PF13679.6 EGD95164.1 - 0.11 12.5 0.0 0.17 11.9 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain RrnaAD PF00398.20 EGD95164.1 - 0.19 10.8 0.0 0.31 10.1 0.0 1.3 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase BTB PF00651.31 EGD95165.1 - 3e-06 27.4 0.0 8.6e-06 26.0 0.0 1.8 2 0 0 2 2 2 1 BTB/POZ domain Peptidase_S24 PF00717.23 EGD95166.1 - 5.7e-08 32.6 0.0 8.9e-08 32.0 0.0 1.3 1 0 0 1 1 1 1 Peptidase S24-like UQ_con PF00179.26 EGD95169.1 - 2.6e-42 143.8 0.0 2.9e-42 143.6 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EGD95169.1 - 2.2e-06 27.4 0.0 2.8e-06 27.1 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.13 EGD95169.1 - 0.037 13.9 0.0 0.06 13.2 0.0 1.3 1 0 0 1 1 1 0 UEV domain RWD PF05773.22 EGD95169.1 - 0.069 13.4 0.1 0.1 12.9 0.1 1.5 1 1 0 1 1 1 0 RWD domain Acyl_transf_3 PF01757.22 EGD95170.1 - 1.2e-08 34.4 27.0 3.9e-06 26.2 0.5 3.0 1 1 2 3 3 3 3 Acyltransferase family CAP_N PF01213.19 EGD95171.1 - 3.2 7.2 12.1 4 6.8 12.1 1.2 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal CDC27 PF09507.10 EGD95171.1 - 5.6 6.2 7.8 6.1 6.1 7.8 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 RabGAP-TBC PF00566.18 EGD95172.1 - 2e-34 119.2 0.5 4.3e-31 108.3 0.1 3.0 3 1 0 3 3 3 2 Rab-GTPase-TBC domain BCS1_N PF08740.11 EGD95174.1 - 4.6e-49 166.9 0.7 6.8e-49 166.4 0.7 1.3 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.29 EGD95174.1 - 6e-13 49.4 0.0 3.1e-05 24.4 0.0 2.5 1 1 1 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EGD95174.1 - 0.0001 22.7 0.0 0.00028 21.3 0.0 1.9 1 1 0 1 1 1 1 AAA ATPase domain AAA_7 PF12775.7 EGD95174.1 - 0.00062 19.3 0.0 0.0015 18.1 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_33 PF13671.6 EGD95174.1 - 0.0024 18.0 0.0 0.0059 16.8 0.0 1.7 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 EGD95174.1 - 0.0094 16.3 0.0 0.033 14.6 0.0 1.9 2 0 0 2 2 1 1 RNA helicase AAA_22 PF13401.6 EGD95174.1 - 0.011 16.1 0.0 0.075 13.3 0.0 2.3 3 0 0 3 3 3 0 AAA domain AAA_11 PF13086.6 EGD95174.1 - 0.013 15.3 0.0 0.037 13.8 0.0 1.6 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 EGD95174.1 - 0.014 15.1 0.0 0.055 13.2 0.0 2.0 1 0 0 1 1 1 0 P-loop containing region of AAA domain Rad17 PF03215.15 EGD95174.1 - 0.023 14.6 0.0 0.06 13.3 0.0 1.7 1 0 0 1 1 1 0 Rad17 P-loop domain DUF815 PF05673.13 EGD95174.1 - 0.036 13.2 0.0 0.41 9.8 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA_5 PF07728.14 EGD95174.1 - 0.044 13.8 0.0 0.13 12.2 0.0 1.9 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 EGD95174.1 - 0.045 14.3 0.0 0.11 13.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 EGD95174.1 - 0.046 13.4 0.0 0.098 12.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 EGD95174.1 - 0.065 13.7 0.0 0.14 12.7 0.0 1.6 1 0 0 1 1 1 0 ABC transporter ATPase PF06745.13 EGD95174.1 - 0.076 12.3 0.0 0.14 11.5 0.0 1.4 1 0 0 1 1 1 0 KaiC MMR_HSR1 PF01926.23 EGD95174.1 - 0.14 12.3 0.0 0.35 11.0 0.0 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase Lactamase_B_3 PF13483.6 EGD95175.1 - 7e-09 35.8 0.0 2.3e-08 34.1 0.0 1.9 3 0 0 3 3 3 1 Beta-lactamase superfamily domain Lactamase_B_2 PF12706.7 EGD95175.1 - 1.6e-06 27.8 0.0 1.3e-05 24.8 0.0 2.0 2 0 0 2 2 2 1 Beta-lactamase superfamily domain Cpn60_TCP1 PF00118.24 EGD95176.1 - 3.6e-172 573.4 1.5 4.1e-172 573.2 1.5 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family zf-PARP PF00645.18 EGD95177.1 - 2.7e-22 79.4 0.5 2.7e-22 79.4 0.5 3.8 2 1 0 2 2 2 1 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region Kinesin PF00225.23 EGD95178.1 - 1.9e-23 83.0 0.0 3.2e-23 82.2 0.0 1.2 1 0 0 1 1 1 1 Kinesin motor domain bZIP_2 PF07716.15 EGD95178.1 - 0.00023 21.2 0.5 0.00069 19.6 0.5 1.9 1 0 0 1 1 1 1 Basic region leucine zipper AAA_13 PF13166.6 EGD95178.1 - 0.0081 14.9 3.3 0.012 14.3 3.3 1.2 1 0 0 1 1 1 1 AAA domain Peptidase_M32 PF02074.15 EGD95178.1 - 0.12 11.2 0.0 0.12 11.2 0.0 1.8 2 0 0 2 2 2 0 Carboxypeptidase Taq (M32) metallopeptidase TPR_14 PF13428.6 EGD95179.1 - 0.028 15.2 4.4 5 8.2 0.0 4.3 3 0 0 3 3 3 0 Tetratricopeptide repeat ChAPs PF09295.10 EGD95180.1 - 7.4e-153 509.2 0.0 1e-152 508.7 0.0 1.2 1 0 0 1 1 1 1 ChAPs (Chs5p-Arf1p-binding proteins) TPR_2 PF07719.17 EGD95180.1 - 0.0004 20.3 0.1 0.96 9.7 0.0 4.0 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_1 PF00515.28 EGD95180.1 - 0.00056 19.6 0.2 8 6.5 0.0 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 EGD95180.1 - 0.0006 20.4 1.7 0.67 10.9 0.0 4.4 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_19 PF14559.6 EGD95180.1 - 0.0037 17.8 0.0 6.4 7.4 0.0 2.9 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_9 PF13371.6 EGD95180.1 - 0.0049 17.0 0.1 0.68 10.1 0.0 2.8 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 EGD95180.1 - 0.052 13.8 0.6 1 9.7 0.1 3.0 2 1 0 2 2 2 0 Tetratricopeptide repeat CDC45 PF02724.14 EGD95180.1 - 0.063 11.6 4.2 0.083 11.2 4.2 1.1 1 0 0 1 1 1 0 CDC45-like protein ANAPC3 PF12895.7 EGD95180.1 - 0.62 10.3 3.2 1.5 9.1 0.3 2.9 3 1 1 4 4 3 0 Anaphase-promoting complex, cyclosome, subunit 3 Nop14 PF04147.12 EGD95180.1 - 0.74 7.9 8.4 1.1 7.4 8.4 1.2 1 0 0 1 1 1 0 Nop14-like family NOA36 PF06524.12 EGD95180.1 - 0.77 9.0 9.0 1.5 8.0 9.0 1.4 1 0 0 1 1 1 0 NOA36 protein PBP1_TM PF14812.6 EGD95180.1 - 0.82 10.1 8.0 0.7 10.3 6.3 1.7 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal RRN3 PF05327.11 EGD95180.1 - 3.2 6.2 6.4 5 5.5 6.4 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Exo5 PF09810.9 EGD95182.1 - 2.2e-109 366.3 0.0 1.4e-107 360.4 0.0 2.2 1 1 0 1 1 1 1 Exonuclease V - a 5' deoxyribonuclease PDDEXK_1 PF12705.7 EGD95182.1 - 0.0045 16.9 1.7 1.3 8.9 0.0 3.3 3 1 0 3 3 3 2 PD-(D/E)XK nuclease superfamily DUF3799 PF12684.7 EGD95182.1 - 0.11 12.2 0.0 1.5 8.5 0.0 2.2 2 0 0 2 2 2 0 PDDEXK-like domain of unknown function (DUF3799) Mpv17_PMP22 PF04117.12 EGD95183.1 - 1.2e-13 51.1 0.4 1.2e-13 51.1 0.4 2.0 2 1 0 2 2 2 1 Mpv17 / PMP22 family Oxidored_q4 PF00507.19 EGD95183.1 - 0.07 13.3 0.0 0.07 13.3 0.0 1.9 3 0 0 3 3 3 0 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 Histone PF00125.24 EGD95184.1 - 2.5e-49 167.0 3.3 2.8e-49 166.8 3.3 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.6 EGD95184.1 - 5.3e-06 26.7 0.0 8.2e-06 26.1 0.0 1.2 1 0 0 1 1 1 1 CENP-S protein CENP-T_C PF15511.6 EGD95184.1 - 6e-05 23.1 0.7 8.5e-05 22.6 0.1 1.6 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold PAF PF15715.5 EGD95184.1 - 0.0013 19.4 1.2 0.0015 19.1 1.2 1.2 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CBFD_NFYB_HMF PF00808.23 EGD95184.1 - 0.0077 16.5 0.2 0.025 14.9 0.0 1.8 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Bromo_TP PF07524.13 EGD95184.1 - 0.025 14.6 0.0 0.042 13.9 0.0 1.3 1 0 0 1 1 1 0 Bromodomain associated TFIID-31kDa PF02291.15 EGD95184.1 - 0.13 12.3 0.1 0.22 11.6 0.1 1.4 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit CENP-T_C PF15511.6 EGD95185.1 - 1.1e-08 35.1 0.0 1.4e-08 34.8 0.0 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold Histone PF00125.24 EGD95185.1 - 3.7e-05 24.1 0.1 4.2e-05 23.9 0.1 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TAF PF02969.17 EGD95185.1 - 0.00012 22.2 0.1 0.00017 21.7 0.1 1.4 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) CENP-S PF15630.6 EGD95185.1 - 0.00049 20.4 0.1 0.00066 20.0 0.1 1.4 1 1 0 1 1 1 1 CENP-S protein CBFD_NFYB_HMF PF00808.23 EGD95185.1 - 0.00053 20.2 0.1 0.0011 19.2 0.0 1.6 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 EGD95185.1 - 0.0087 16.1 0.0 0.01 15.9 0.0 1.1 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 EGD95185.1 - 0.052 13.6 0.0 0.08 13.0 0.0 1.2 1 0 0 1 1 1 0 Bromodomain associated HIGH_NTase1_ass PF16581.5 EGD95185.1 - 0.15 12.0 0.0 0.17 11.9 0.0 1.1 1 0 0 1 1 1 0 Cytidyltransferase-related C-terminal region zf-C2H2 PF00096.26 EGD95188.1 - 0.00013 22.3 33.0 0.00016 22.0 1.4 4.4 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EGD95188.1 - 0.029 15.2 1.1 0.029 15.2 1.1 4.7 4 0 0 4 4 4 0 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EGD95188.1 - 1.6 9.3 11.1 13 6.4 0.0 3.9 3 0 0 3 3 3 0 Zinc-finger double domain Glyco_transf_22 PF03901.17 EGD95189.1 - 7.8e-87 292.2 15.6 9.1e-87 292.0 15.6 1.0 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family HET PF06985.11 EGD95190.1 - 2.4e-09 37.7 0.0 4.9e-09 36.7 0.0 1.5 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) DUF3128 PF11326.8 EGD95190.1 - 0.054 13.9 0.1 0.17 12.3 0.1 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3128) Gar1 PF04410.14 EGD95191.1 - 2.9e-45 153.8 0.2 6.5e-45 152.7 0.2 1.6 1 0 0 1 1 1 1 Gar1/Naf1 RNA binding region YL1 PF05764.13 EGD95191.1 - 2.6 8.1 12.1 6.2 6.9 5.4 2.2 2 0 0 2 2 2 0 YL1 nuclear protein RRM_1 PF00076.22 EGD95193.1 - 2.7e-05 23.9 0.0 4.7e-05 23.1 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Methyltransf_28 PF02636.17 EGD95194.1 - 1.4e-82 277.3 0.0 2e-82 276.7 0.0 1.3 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase Rhodanese PF00581.20 EGD95195.1 - 1.9e-09 38.0 0.0 2.3e-09 37.7 0.0 1.1 1 0 0 1 1 1 1 Rhodanese-like domain Ribosomal_S21 PF01165.20 EGD95196.1 - 1.2e-07 31.3 1.3 1.7e-07 30.9 0.3 1.8 2 0 0 2 2 2 1 Ribosomal protein S21 PGI PF00342.19 EGD95198.1 - 1.1e-240 799.3 2.5 1.3e-240 799.1 2.5 1.0 1 0 0 1 1 1 1 Phosphoglucose isomerase Urease_beta PF00699.20 EGD95198.1 - 0.02 14.9 0.0 0.045 13.8 0.0 1.5 1 0 0 1 1 1 0 Urease beta subunit PUD1_2 PF18457.1 EGD95200.1 - 2.4e-42 144.9 0.6 2.8e-42 144.7 0.6 1.0 1 0 0 1 1 1 1 Up-Regulated in long-lived daf-2 PWI PF01480.17 EGD95201.1 - 6.1e-17 61.7 0.7 1.5e-16 60.4 0.7 1.7 1 0 0 1 1 1 1 PWI domain RRM_1 PF00076.22 EGD95201.1 - 0.07 13.0 0.0 0.18 11.7 0.0 1.7 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Aminotran_5 PF00266.19 EGD95202.1 - 5.4e-26 91.4 0.0 9.4e-26 90.6 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V MR_MLE_C PF13378.6 EGD95203.1 - 1.3e-56 191.7 0.1 3.6e-56 190.2 0.0 1.6 2 0 0 2 2 2 1 Enolase C-terminal domain-like MR_MLE_N PF02746.16 EGD95203.1 - 3e-07 30.6 0.1 6e-07 29.7 0.1 1.4 1 0 0 1 1 1 1 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain MAAL_C PF07476.11 EGD95203.1 - 0.0052 16.0 0.0 0.015 14.5 0.0 1.7 2 0 0 2 2 2 1 Methylaspartate ammonia-lyase C-terminus TIM21 PF08294.11 EGD95204.1 - 4e-39 133.8 0.0 5.1e-39 133.5 0.0 1.1 1 0 0 1 1 1 1 TIM21 Coa1 PF08695.10 EGD95204.1 - 2.8e-06 27.1 0.0 6e-06 26.0 0.0 1.5 1 1 0 1 1 1 1 Cytochrome oxidase complex assembly protein 1 ArfGap PF01412.18 EGD95205.1 - 9.8e-35 119.2 0.4 1.7e-34 118.4 0.4 1.4 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf Pterin_bind PF00809.22 EGD95206.1 - 1.4e-80 270.5 0.2 1.8e-80 270.1 0.2 1.2 1 0 0 1 1 1 1 Pterin binding enzyme HPPK PF01288.20 EGD95206.1 - 3.3e-35 121.0 0.0 7.1e-35 119.9 0.0 1.6 1 0 0 1 1 1 1 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) NMO PF03060.15 EGD95207.1 - 1.5e-56 192.2 1.3 2e-56 191.8 1.3 1.2 1 0 0 1 1 1 1 Nitronate monooxygenase IMPDH PF00478.25 EGD95207.1 - 6.6e-11 41.8 0.6 1.8e-09 37.1 0.7 2.2 1 1 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain FMN_dh PF01070.18 EGD95207.1 - 1e-07 31.3 1.8 1.7e-07 30.6 1.8 1.3 1 0 0 1 1 1 1 FMN-dependent dehydrogenase DHO_dh PF01180.21 EGD95207.1 - 0.003 16.8 0.2 0.0049 16.1 0.2 1.3 1 0 0 1 1 1 1 Dihydroorotate dehydrogenase Glu_synthase PF01645.17 EGD95207.1 - 0.0044 16.2 1.2 0.0079 15.4 1.2 1.4 1 0 0 1 1 1 1 Conserved region in glutamate synthase eIF3g PF12353.8 EGD95208.1 - 5.6e-45 152.8 1.6 5.6e-45 152.8 1.6 1.5 2 0 0 2 2 2 1 Eukaryotic translation initiation factor 3 subunit G RRM_1 PF00076.22 EGD95208.1 - 2.2e-17 62.6 0.2 3.6e-17 61.9 0.2 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EGD95208.1 - 0.0065 16.3 0.0 0.014 15.2 0.0 1.6 1 0 0 1 1 1 1 Occluded RNA-recognition motif zf-CCCH_7 PF18586.1 EGD95208.1 - 0.0095 16.2 0.1 0.023 15.0 0.1 1.6 1 0 0 1 1 1 1 Chromatin remodeling factor Mit1 C-terminal Zn finger 1 TackOD1 PF18551.1 EGD95208.1 - 0.049 13.3 0.1 0.086 12.5 0.1 1.3 1 0 0 1 1 1 0 Thaumarchaeal output domain 1 NDT80_PhoG PF05224.12 EGD95211.1 - 3e-41 141.7 0.0 4.6e-41 141.1 0.0 1.3 1 0 0 1 1 1 1 NDT80 / PhoG like DNA-binding family PHO4 PF01384.20 EGD95212.1 - 4.1e-77 259.5 9.4 5e-77 259.2 9.4 1.0 1 0 0 1 1 1 1 Phosphate transporter family DUF4229 PF14012.6 EGD95212.1 - 2 8.6 5.8 1.4 9.1 0.2 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF4229) MFS_1 PF07690.16 EGD95213.1 - 3.8e-11 42.5 56.7 1.1e-07 31.1 17.9 2.7 2 1 0 3 3 3 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EGD95213.1 - 0.0002 20.4 11.6 0.0002 20.4 11.6 3.1 2 1 0 2 2 2 1 Sugar (and other) transporter TANGO2 PF05742.12 EGD95214.1 - 1.6e-73 247.9 0.0 1.8e-73 247.7 0.0 1.0 1 0 0 1 1 1 1 Transport and Golgi organisation 2 BPL_N PF09825.9 EGD95215.1 - 1.3e-146 488.5 0.0 5.3e-146 486.5 0.0 1.8 1 1 1 2 2 2 1 Biotin-protein ligase, N terminal BPL_LplA_LipB PF03099.19 EGD95215.1 - 1.3e-17 64.0 0.0 2.6e-17 63.0 0.0 1.6 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family BPL_C PF02237.17 EGD95215.1 - 6.7e-06 25.9 0.0 1.3e-05 25.0 0.0 1.5 1 0 0 1 1 1 1 Biotin protein ligase C terminal domain CHCH PF06747.13 EGD95216.1 - 3.4e-06 27.1 4.9 4.2e-06 26.7 4.9 1.2 1 0 0 1 1 1 1 CHCH domain Cmc1 PF08583.10 EGD95216.1 - 0.0091 16.0 1.5 0.013 15.5 1.3 1.4 1 1 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like CX9C PF16860.5 EGD95216.1 - 0.08 13.0 1.2 0.087 12.9 0.6 1.4 1 1 0 1 1 1 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, Mgm101p PF06420.12 EGD95217.1 - 1.2e-87 291.8 0.0 1.3e-87 291.6 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial genome maintenance MGM101 zf-RING_2 PF13639.6 EGD95218.1 - 2e-13 50.5 5.4 3.1e-13 49.8 5.4 1.3 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 EGD95218.1 - 2.1e-10 40.1 1.6 3.5e-10 39.4 1.6 1.4 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 EGD95218.1 - 8.4e-09 35.1 5.0 1.4e-08 34.5 5.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EGD95218.1 - 7.1e-08 32.2 2.1 1.2e-07 31.5 2.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EGD95218.1 - 1.8e-06 28.2 5.8 5.8e-06 26.5 5.8 1.8 1 1 0 1 1 1 1 RING-H2 zinc finger domain Prok-RING_4 PF14447.6 EGD95218.1 - 1.1e-05 25.1 6.7 0.00016 21.4 6.6 2.3 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 EGD95218.1 - 3.9e-05 23.5 1.7 6.7e-05 22.8 1.7 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 EGD95218.1 - 7.1e-05 22.6 1.9 0.00014 21.6 1.9 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EGD95218.1 - 0.00013 21.9 4.3 0.00027 20.9 4.3 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-ANAPC11 PF12861.7 EGD95218.1 - 0.00044 20.3 1.5 0.00087 19.3 1.5 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_4 PF14570.6 EGD95218.1 - 0.014 15.1 2.9 0.027 14.3 2.9 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING-like PF08746.11 EGD95218.1 - 0.11 12.9 1.1 0.22 11.9 1.1 1.6 1 0 0 1 1 1 0 RING-like domain Zn_ribbon_17 PF17120.5 EGD95218.1 - 0.21 11.3 1.2 0.35 10.5 1.2 1.3 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type Prok-RING_1 PF14446.6 EGD95218.1 - 0.26 11.2 3.8 0.35 10.8 1.4 2.1 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 PHD PF00628.29 EGD95218.1 - 0.78 9.7 2.7 1.6 8.7 2.7 1.6 1 0 0 1 1 1 0 PHD-finger zf-C3HC4_4 PF15227.6 EGD95218.1 - 0.95 9.7 5.1 1.9 8.7 5.1 1.5 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING FANCL_C PF11793.8 EGD95218.1 - 2.5 8.3 6.4 3.8 7.8 3.8 2.5 2 1 0 2 2 2 0 FANCL C-terminal domain NLPC_P60 PF00877.19 EGD95219.1 - 0.0016 18.4 0.2 0.0025 17.8 0.2 1.3 1 0 0 1 1 1 1 NlpC/P60 family Phage_lysozyme PF00959.19 EGD95220.1 - 2.2e-12 47.4 0.0 2.9e-12 47.0 0.0 1.1 1 0 0 1 1 1 1 Phage lysozyme Stanniocalcin PF03298.13 EGD95221.1 - 0.00036 19.9 0.0 0.0005 19.4 0.0 1.2 1 0 0 1 1 1 1 Stanniocalcin family MS_channel PF00924.18 EGD95222.1 - 2e-19 70.0 0.5 4.2e-19 68.9 0.5 1.5 1 0 0 1 1 1 1 Mechanosensitive ion channel EF-hand_7 PF13499.6 EGD95222.1 - 0.54 10.8 1.6 0.83 10.1 0.1 2.1 3 0 0 3 3 3 0 EF-hand domain pair EF-hand_1 PF00036.32 EGD95222.1 - 3.3 7.5 5.3 0.28 10.8 0.2 2.0 2 0 0 2 2 2 0 EF hand TraG_N PF07916.11 EGD95222.1 - 8.7 5.1 8.4 0.11 11.4 0.1 1.9 2 0 0 2 2 2 0 TraG-like protein, N-terminal region Pkinase PF00069.25 EGD95223.1 - 0.084 12.2 0.7 3 7.1 0.0 2.1 1 1 1 2 2 2 0 Protein kinase domain MRPL52 PF18699.1 EGD95226.1 - 0.05 13.8 1.2 2.5 8.3 0.0 2.2 2 0 0 2 2 2 0 Mitoribosomal protein mL52 Aminotran_1_2 PF00155.21 EGD95227.1 - 5.6e-77 259.4 0.0 6.4e-77 259.2 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Syntaxin-18_N PF10496.9 EGD95229.1 - 7.5e-09 35.7 0.4 6.4e-08 32.7 0.0 2.5 2 0 0 2 2 2 1 SNARE-complex protein Syntaxin-18 N-terminus SNARE PF05739.19 EGD95229.1 - 3.5e-06 26.9 0.4 9.2e-06 25.6 0.1 1.8 2 0 0 2 2 2 1 SNARE domain DUF1897 PF09005.10 EGD95229.1 - 1 8.9 3.0 19 4.8 0.1 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF1897) DUF4404 PF14357.6 EGD95229.1 - 8.6 7.1 7.4 3.2 8.4 0.1 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4404) TPR_1 PF00515.28 EGD95230.1 - 9.7e-14 50.5 7.3 3.1e-07 29.9 0.2 4.5 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 EGD95230.1 - 2.4e-13 49.1 5.8 1.5e-05 24.8 0.1 4.6 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_12 PF13424.6 EGD95230.1 - 4.7e-10 39.6 0.3 1.2e-05 25.5 0.0 3.1 2 1 1 3 3 3 2 Tetratricopeptide repeat PB1 PF00564.24 EGD95230.1 - 2.8e-07 30.4 0.1 5.5e-07 29.4 0.1 1.4 1 0 0 1 1 1 1 PB1 domain TPR_7 PF13176.6 EGD95230.1 - 1.2e-06 28.1 1.0 0.00026 20.8 0.1 3.6 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 EGD95230.1 - 9.6e-06 25.2 4.6 7.9e-05 22.3 0.8 3.5 2 1 1 3 3 3 1 TPR repeat TPR_8 PF13181.6 EGD95230.1 - 1.4e-05 24.9 7.1 0.0012 18.8 0.1 4.5 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_6 PF13174.6 EGD95230.1 - 1.7e-05 25.2 0.2 8.3 7.3 0.0 4.5 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 EGD95230.1 - 0.00018 22.1 0.2 0.03 15.0 0.0 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_9 PF13371.6 EGD95230.1 - 0.0012 18.9 0.0 2.5 8.3 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.6 EGD95230.1 - 0.0063 16.8 0.3 0.36 11.3 0.1 3.4 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 EGD95230.1 - 0.13 13.1 4.1 0.28 12.1 0.1 3.2 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_10 PF13374.6 EGD95230.1 - 0.18 11.7 4.5 1 9.3 0.1 3.6 4 1 1 5 5 3 0 Tetratricopeptide repeat HMA PF00403.26 EGD95231.1 - 2.7e-12 47.0 0.0 5.1e-12 46.0 0.0 1.5 1 0 0 1 1 1 1 Heavy-metal-associated domain Sod_Cu PF00080.20 EGD95231.1 - 6.2e-09 36.2 0.0 9.2e-09 35.6 0.0 1.2 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) Pkinase PF00069.25 EGD95232.1 - 3.1e-62 210.3 0.0 5.5e-62 209.5 0.0 1.4 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD95232.1 - 5.2e-26 91.5 0.0 8.6e-26 90.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EGD95232.1 - 0.0057 16.0 0.0 0.0057 16.0 0.0 1.8 2 0 0 2 2 1 1 Kinase-like Haspin_kinase PF12330.8 EGD95232.1 - 0.033 13.1 0.7 0.06 12.3 0.0 1.7 2 0 0 2 2 2 0 Haspin like kinase domain Kdo PF06293.14 EGD95232.1 - 0.034 13.5 0.1 0.061 12.7 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family LCD1 PF09798.9 EGD95232.1 - 0.2 10.2 0.4 0.25 9.8 0.4 1.1 1 0 0 1 1 1 0 DNA damage checkpoint protein APH PF01636.23 EGD95232.1 - 0.24 11.3 0.0 0.24 11.3 0.0 2.0 2 0 0 2 2 2 0 Phosphotransferase enzyme family MCM_bind PF09739.9 EGD95232.1 - 2.5 6.4 9.5 3.4 6.0 9.5 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor CDC45 PF02724.14 EGD95232.1 - 4.1 5.6 6.6 5.8 5.1 6.6 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF1168 PF06658.12 EGD95232.1 - 6.4 6.6 16.9 13 5.6 16.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1168) Med3 PF11593.8 EGD95232.1 - 9.9 5.2 11.6 14 4.8 11.6 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal RXT2_N PF08595.11 EGD95233.1 - 0.48 10.4 11.0 3.5 7.6 3.8 2.3 2 0 0 2 2 2 0 RXT2-like, N-terminal Cwf_Cwc_15 PF04889.12 EGD95233.1 - 2.2 8.0 18.1 0.71 9.6 7.0 2.2 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein CDC45 PF02724.14 EGD95233.1 - 8.8 4.5 9.2 14 3.8 9.2 1.4 1 1 0 1 1 1 0 CDC45-like protein AMP-binding PF00501.28 EGD95234.1 - 5.6e-220 730.2 0.0 1.9e-76 257.4 0.0 3.2 3 0 0 3 3 3 3 AMP-binding enzyme Condensation PF00668.20 EGD95234.1 - 1.1e-120 403.4 0.0 1.5e-45 155.8 0.1 5.1 4 1 0 4 4 4 4 Condensation domain PP-binding PF00550.25 EGD95234.1 - 1.4e-38 131.0 2.2 6.2e-11 42.5 0.0 5.0 4 0 0 4 4 4 3 Phosphopantetheine attachment site NAD_binding_4 PF07993.12 EGD95234.1 - 2.4e-33 115.4 0.0 6.6e-33 114.0 0.0 1.8 1 1 0 1 1 1 1 Male sterility protein Epimerase PF01370.21 EGD95234.1 - 4.9e-09 36.0 0.0 1.3e-08 34.6 0.0 1.7 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family AMP-binding_C PF13193.6 EGD95234.1 - 1.3e-05 26.1 0.0 0.47 11.5 0.0 3.8 3 0 0 3 3 3 2 AMP-binding enzyme C-terminal domain AvrM_N PF18247.1 EGD95234.1 - 0.16 11.9 0.1 18 5.4 0.0 2.9 2 0 0 2 2 2 0 Flax-rust effector AvrM N-terminal domain Usp PF00582.26 EGD95235.1 - 1.6e-22 80.5 0.1 3.4e-22 79.5 0.1 1.6 1 0 0 1 1 1 1 Universal stress protein family Med27 PF11571.8 EGD95236.1 - 2.5e-20 72.6 2.0 2.8e-20 72.4 0.6 1.8 2 0 0 2 2 2 1 Mediator complex subunit 27 DUF4919 PF16266.5 EGD95236.1 - 0.099 12.6 0.2 0.17 11.8 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4919) SpoIIIAH PF12685.7 EGD95237.1 - 0.00032 20.6 1.5 0.00039 20.3 1.5 1.2 1 0 0 1 1 1 1 SpoIIIAH-like protein MFMR_assoc PF16596.5 EGD95237.1 - 0.0076 16.7 11.7 0.014 15.8 11.7 1.5 1 0 0 1 1 1 1 Disordered region downstream of MFMR GRA6 PF05084.13 EGD95237.1 - 0.06 13.3 2.1 0.12 12.3 2.1 1.4 1 0 0 1 1 1 0 Granule antigen protein (GRA6) AAR2 PF05282.11 EGD95237.1 - 0.085 12.3 0.5 0.12 11.8 0.5 1.1 1 0 0 1 1 1 0 AAR2 protein Presenilin PF01080.17 EGD95237.1 - 0.1 11.3 0.8 0.14 10.9 0.8 1.2 1 0 0 1 1 1 0 Presenilin NPR3 PF03666.13 EGD95237.1 - 0.18 10.6 2.1 0.25 10.1 2.1 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Macoilin PF09726.9 EGD95237.1 - 0.27 9.7 4.1 0.29 9.6 4.1 1.1 1 0 0 1 1 1 0 Macoilin family TraV PF09676.10 EGD95237.1 - 0.53 11.3 5.4 1.5 9.8 3.8 2.0 2 0 0 2 2 2 0 Type IV conjugative transfer system lipoprotein (TraV) SNF2_N PF00176.23 EGD95238.1 - 8.3e-67 225.4 0.0 1.4e-66 224.6 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EGD95238.1 - 4.3e-18 65.7 0.0 1e-17 64.5 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EGD95238.1 - 8.4e-06 25.9 0.0 2.2e-05 24.5 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit TFIIF_beta PF02270.15 EGD95238.1 - 0.0016 18.5 0.1 0.015 15.4 0.0 2.5 2 0 0 2 2 2 1 TFIIF, beta subunit HTH domain SPEG_u2 PF16650.5 EGD95238.1 - 0.0063 16.7 0.4 0.0063 16.7 0.4 1.9 2 0 0 2 2 2 1 Unstructured region on SPEG complex protein AAA_11 PF13086.6 EGD95238.1 - 3.8 7.2 0.0 3.8 7.2 0.0 3.7 4 0 0 4 4 4 0 AAA domain Pkinase PF00069.25 EGD95240.1 - 1.2e-49 169.1 0.1 5.1e-49 167.0 0.1 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD95240.1 - 5.4e-23 81.6 0.1 1.5e-22 80.1 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase APH PF01636.23 EGD95240.1 - 0.00038 20.5 0.1 0.00038 20.5 0.1 2.1 2 0 0 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.22 EGD95240.1 - 0.003 17.2 0.1 0.0081 15.8 0.1 1.7 1 1 0 1 1 1 1 RIO1 family Choline_kinase PF01633.20 EGD95240.1 - 0.42 10.2 2.3 0.4 10.2 0.2 2.0 2 0 0 2 2 2 0 Choline/ethanolamine kinase TAF4 PF05236.14 EGD95240.1 - 0.47 10.2 3.8 0.79 9.4 3.8 1.5 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family eIF-3c_N PF05470.12 EGD95241.1 - 1.1e-168 562.3 28.0 3.7e-136 454.9 4.2 3.1 1 1 2 3 3 3 2 Eukaryotic translation initiation factor 3 subunit 8 N-terminus PCI PF01399.27 EGD95241.1 - 1.8e-13 50.9 3.2 6.6e-12 45.9 0.1 3.8 2 2 2 4 4 4 1 PCI domain DASH_Ask1 PF08655.10 EGD95241.1 - 0.09 12.7 0.2 3.3 7.7 0.1 2.9 2 0 0 2 2 2 0 DASH complex subunit Ask1 CDC45 PF02724.14 EGD95241.1 - 1.6 7.0 18.3 2.4 6.4 18.3 1.2 1 0 0 1 1 1 0 CDC45-like protein EAP30 PF04157.16 EGD95242.1 - 3.9e-71 239.1 0.0 4.5e-71 238.9 0.0 1.0 1 0 0 1 1 1 1 EAP30/Vps36 family Ribosomal_L30_N PF08079.12 EGD95243.1 - 9.2e-27 93.1 15.0 1.9e-26 92.1 15.0 1.6 1 0 0 1 1 1 1 Ribosomal L30 N-terminal domain Ribosomal_L30 PF00327.20 EGD95243.1 - 2.3e-17 62.6 1.7 2.3e-17 62.6 1.7 1.8 2 0 0 2 2 2 1 Ribosomal protein L30p/L7e DNA_pol_B PF00136.21 EGD95244.1 - 1.2e-116 390.2 1.8 1.3e-116 390.1 0.4 1.8 2 0 0 2 2 2 1 DNA polymerase family B zf-DNA_Pol PF08996.10 EGD95244.1 - 2.2e-68 229.7 1.2 3.7e-68 228.9 0.4 1.9 2 0 0 2 2 2 1 DNA Polymerase alpha zinc finger DNA_pol_B_exo1 PF03104.19 EGD95244.1 - 9.7e-47 159.7 0.0 1.9e-46 158.8 0.0 1.5 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain DNA_pol_alpha_N PF12254.8 EGD95244.1 - 4.9e-25 87.4 9.9 4.9e-25 87.4 9.9 2.6 2 0 0 2 2 2 1 DNA polymerase alpha subunit p180 N terminal DNA_pol_B_2 PF03175.13 EGD95244.1 - 0.00082 18.4 0.0 0.0018 17.2 0.0 1.5 1 0 0 1 1 1 1 DNA polymerase type B, organellar and viral HSP70 PF00012.20 EGD95245.1 - 2.4e-263 874.8 16.0 2.7e-263 874.6 16.0 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EGD95245.1 - 1.5e-14 53.6 6.2 1e-12 47.5 2.1 2.5 2 0 0 2 2 2 2 MreB/Mbl protein FGGY_C PF02782.16 EGD95245.1 - 9.7e-05 22.2 0.0 0.00032 20.5 0.0 1.9 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain StbA PF06406.11 EGD95245.1 - 0.012 14.8 5.8 0.09 12.0 0.1 3.3 3 1 1 4 4 4 0 StbA protein DUF1464 PF07318.12 EGD95245.1 - 0.041 13.0 1.1 0.58 9.3 0.0 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF1464) Scaffolding_pro PF11418.8 EGD95245.1 - 0.077 13.6 0.5 0.2 12.2 0.5 1.6 1 0 0 1 1 1 0 Phi29 scaffolding protein SMBP PF16785.5 EGD95245.1 - 0.092 13.0 3.9 0.1 12.8 1.4 2.2 2 0 0 2 2 2 0 Small metal-binding protein Histone_HNS PF00816.21 EGD95245.1 - 4.4 8.2 10.5 17 6.4 3.9 3.2 3 0 0 3 3 3 0 H-NS histone family FtsA PF14450.6 EGD95245.1 - 7.1 7.1 13.3 1.3 9.5 0.9 3.9 3 3 0 3 3 3 0 Cell division protein FtsA DUF2415 PF10313.9 EGD95246.1 - 9.6e-16 57.4 0.0 2.5e-15 56.1 0.0 1.8 1 0 0 1 1 1 1 Uncharacterised protein domain (DUF2415) PRIMA1 PF16101.5 EGD95246.1 - 4 7.5 6.6 9.8 6.2 6.6 1.7 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 CAP_N PF01213.19 EGD95246.1 - 4.8 6.6 9.3 9.2 5.6 9.3 1.4 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal DSHCT PF08148.12 EGD95248.1 - 2.2e-51 173.8 0.5 4.7e-51 172.7 0.5 1.6 1 0 0 1 1 1 1 DSHCT (NUC185) domain Ski2_N PF17911.1 EGD95248.1 - 6.3e-41 139.3 0.0 1.2e-40 138.4 0.0 1.5 1 0 0 1 1 1 1 Ski2 N-terminal region rRNA_proc-arch PF13234.6 EGD95248.1 - 8.9e-18 65.2 0.6 4e-17 63.0 0.1 2.4 2 1 0 2 2 2 1 rRNA-processing arch domain DEAD PF00270.29 EGD95248.1 - 5.3e-17 62.1 0.0 1.1e-16 61.1 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EGD95248.1 - 7e-06 26.4 0.0 1.9e-05 24.9 0.0 1.9 1 1 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EGD95248.1 - 0.00023 21.2 0.0 0.00051 20.1 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit IBN_N PF03810.19 EGD95249.1 - 1e-15 57.4 0.0 1.4e-13 50.5 0.0 3.8 4 0 0 4 4 4 1 Importin-beta N-terminal domain Cse1 PF08506.10 EGD95249.1 - 1.3e-06 27.5 0.0 3.2e-06 26.2 0.0 1.7 1 0 0 1 1 1 1 Cse1 HEAT_2 PF13646.6 EGD95249.1 - 4.5e-05 23.7 0.1 0.45 10.9 0.0 3.6 2 1 1 3 3 3 2 HEAT repeats GRIP PF01465.20 EGD95249.1 - 0.00083 19.2 0.0 0.0092 15.9 0.0 2.9 1 1 0 1 1 1 1 GRIP domain Xpo1 PF08389.12 EGD95249.1 - 0.0015 18.6 2.4 0.019 15.0 0.1 3.7 3 1 0 3 3 3 1 Exportin 1-like protein RTP1_C1 PF10363.9 EGD95249.1 - 0.0053 16.9 0.1 0.13 12.5 0.1 3.0 2 0 0 2 2 2 1 Required for nuclear transport of RNA pol II C-terminus 1 CAS_CSE1 PF03378.15 EGD95249.1 - 0.0062 15.1 0.2 0.13 10.8 0.0 2.8 3 0 0 3 3 3 1 CAS/CSE protein, C-terminus Vac14_Fab1_bd PF12755.7 EGD95249.1 - 0.056 14.1 0.2 1.6 9.4 0.0 3.4 2 0 0 2 2 2 0 Vacuolar 14 Fab1-binding region Telomere_reg-2 PF10193.9 EGD95249.1 - 0.091 13.2 0.4 0.46 11.0 0.1 2.4 2 0 0 2 2 2 0 Telomere length regulation protein HEAT_EZ PF13513.6 EGD95249.1 - 0.14 12.7 1.9 22 5.7 0.0 4.6 6 0 0 6 6 6 0 HEAT-like repeat RRM_1 PF00076.22 EGD95250.1 - 5.3e-08 32.6 0.0 1.2e-07 31.5 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EGD95250.1 - 1.1e-05 25.3 0.0 2.1e-05 24.4 0.0 1.4 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif RRM_occluded PF16842.5 EGD95250.1 - 0.00075 19.3 0.0 0.0044 16.8 0.0 2.1 2 0 0 2 2 2 1 Occluded RNA-recognition motif PHM7_cyt PF14703.6 EGD95250.1 - 0.023 14.9 0.4 0.26 11.5 0.1 2.4 1 1 1 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter CENP-F_N PF10481.9 EGD95251.1 - 0.13 11.9 6.9 0.77 9.3 6.9 2.0 1 1 0 1 1 1 0 Cenp-F N-terminal domain SlyX PF04102.12 EGD95251.1 - 0.86 10.3 4.5 15 6.3 0.1 2.4 2 0 0 2 2 2 0 SlyX Mito_fiss_reg PF05308.11 EGD95251.1 - 2.4 8.2 15.4 0.05 13.7 5.3 2.5 1 1 1 2 2 2 0 Mitochondrial fission regulator FlaC_arch PF05377.11 EGD95251.1 - 3.6 8.1 4.4 2.5 8.5 0.3 2.2 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) AP3D1 PF06375.11 EGD95252.1 - 0.0039 17.4 8.6 0.0039 17.4 8.6 3.1 4 0 0 4 4 4 1 AP-3 complex subunit delta-1 Ferlin_C PF16165.5 EGD95252.1 - 1.6 8.6 8.7 3.4 7.6 2.8 2.4 2 0 0 2 2 2 0 Ferlin C-terminus DUF501 PF04417.12 EGD95252.1 - 2.6 7.9 5.5 8.7 6.1 5.5 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF501) DUF1168 PF06658.12 EGD95252.1 - 3.9 7.3 30.4 0.28 11.0 16.3 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1168) DbpA PF03880.15 EGD95253.1 - 0.0028 17.6 0.0 0.0051 16.8 0.0 1.4 1 0 0 1 1 1 1 DbpA RNA binding domain Neur_chan_memb PF02932.16 EGD95253.1 - 6.4 6.8 13.8 3.8 7.5 7.4 2.5 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region MFS_1 PF07690.16 EGD95255.1 - 3.6e-33 115.0 24.7 3.4e-32 111.7 10.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EGD95255.1 - 5e-09 35.5 5.5 5e-09 35.5 5.5 2.4 2 1 0 2 2 2 1 Sugar (and other) transporter Fungal_TACC PF12709.7 EGD95256.1 - 1.5e-09 38.2 24.5 1.4e-08 35.1 3.5 4.4 3 1 2 5 5 5 2 Fungal Transforming acidic coiled-coil (TACC) proteins DUF1664 PF07889.12 EGD95256.1 - 0.013 15.6 5.3 0.013 15.6 5.3 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) Pox_A_type_inc PF04508.12 EGD95256.1 - 0.11 12.4 0.7 1.6 8.7 0.0 3.3 4 0 0 4 4 4 0 Viral A-type inclusion protein repeat DUF4407 PF14362.6 EGD95256.1 - 0.23 10.7 29.1 0.31 10.3 8.6 2.3 1 1 0 2 2 2 0 Domain of unknown function (DUF4407) Z1 PF10593.9 EGD95256.1 - 0.53 9.7 7.0 5.9 6.3 1.4 2.6 2 0 0 2 2 2 0 Z1 domain MscS_porin PF12795.7 EGD95256.1 - 0.62 9.6 28.7 5.3 6.5 8.1 3.7 1 1 2 3 3 3 0 Mechanosensitive ion channel porin domain AAA_13 PF13166.6 EGD95256.1 - 0.69 8.5 23.2 0.47 9.0 8.0 2.2 2 0 0 2 2 2 0 AAA domain Fib_alpha PF08702.10 EGD95256.1 - 0.89 9.7 13.2 2.2 8.5 0.6 3.4 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family DUF745 PF05335.13 EGD95256.1 - 1 9.0 31.2 0.035 13.8 14.1 2.9 1 1 2 3 3 3 0 Protein of unknown function (DUF745) DUF2959 PF11172.8 EGD95256.1 - 1.3 9.2 17.3 0.95 9.6 11.1 2.4 1 1 2 3 3 3 0 Protein of unknown function (DUF2959) Fez1 PF06818.15 EGD95256.1 - 2.3 8.6 37.8 25 5.2 20.0 2.7 1 1 1 2 2 2 0 Fez1 ATG16 PF08614.11 EGD95256.1 - 3.6 7.8 45.5 0.42 10.8 6.7 4.2 1 1 3 4 4 4 0 Autophagy protein 16 (ATG16) ERM PF00769.19 EGD95256.1 - 6.3 6.5 46.5 3.2 7.5 31.3 2.7 1 1 1 2 2 2 0 Ezrin/radixin/moesin family GAS PF13851.6 EGD95256.1 - 6.4 6.1 33.9 1 8.7 12.9 2.9 2 1 0 2 2 2 0 Growth-arrest specific micro-tubule binding FAD_binding_3 PF01494.19 EGD95257.1 - 7.1e-12 45.2 0.2 2e-11 43.8 0.0 1.8 2 1 0 2 2 2 1 FAD binding domain Lycopene_cycl PF05834.12 EGD95257.1 - 0.00011 21.4 1.0 0.53 9.3 0.0 3.0 3 0 0 3 3 3 2 Lycopene cyclase protein DAO PF01266.24 EGD95257.1 - 0.00034 20.3 0.1 0.0008 19.1 0.1 1.5 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EGD95257.1 - 0.0056 16.9 1.1 0.053 13.8 0.1 2.8 2 1 0 3 3 3 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 EGD95257.1 - 0.035 14.1 0.0 0.28 11.2 0.0 2.1 2 0 0 2 2 2 0 FAD-NAD(P)-binding SE PF08491.10 EGD95257.1 - 0.05 12.7 0.0 0.073 12.1 0.0 1.2 1 0 0 1 1 1 0 Squalene epoxidase DegT_DnrJ_EryC1 PF01041.17 EGD95257.1 - 0.12 11.6 0.0 0.2 10.9 0.0 1.2 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family Fungal_trans PF04082.18 EGD95259.1 - 7.6e-31 107.1 0.5 1.2e-30 106.5 0.5 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain MFS_1 PF07690.16 EGD95260.1 - 3.3e-06 26.3 22.3 4.2e-06 25.9 17.6 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily UNC-93 PF05978.16 EGD95260.1 - 0.0078 15.9 7.0 0.062 13.0 4.3 2.8 1 1 0 1 1 1 1 Ion channel regulatory protein UNC-93 Ni_hydr_CYTB PF01292.20 EGD95260.1 - 0.11 12.1 5.9 0.12 11.9 4.9 1.6 1 1 0 1 1 1 0 Prokaryotic cytochrome b561 Amidohydro_1 PF01979.20 EGD95261.1 - 2.5e-17 63.2 0.0 1.7e-16 60.5 0.0 2.0 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 EGD95261.1 - 7.4e-13 48.8 1.2 1.2e-08 34.9 0.1 2.2 2 0 0 2 2 2 2 Amidohydrolase family GMC_oxred_C PF05199.13 EGD95262.1 - 5.2e-37 127.6 0.0 7.2e-37 127.1 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_N PF00732.19 EGD95262.1 - 4.4e-36 124.8 0.0 8.4e-19 68.0 0.0 2.1 1 1 1 2 2 2 2 GMC oxidoreductase Lycopene_cycl PF05834.12 EGD95262.1 - 2.6e-05 23.5 0.0 3.7e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein NAD_binding_8 PF13450.6 EGD95262.1 - 4.7e-05 23.5 0.1 0.00019 21.6 0.1 2.1 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EGD95262.1 - 0.0012 18.5 0.1 0.0024 17.5 0.1 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EGD95262.1 - 0.0031 16.8 0.0 0.0054 16.0 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 EGD95262.1 - 0.012 14.5 0.0 0.017 14.0 0.0 1.2 1 0 0 1 1 1 0 Tryptophan halogenase Thi4 PF01946.17 EGD95262.1 - 0.033 13.4 0.1 0.36 10.0 0.1 2.1 2 0 0 2 2 2 0 Thi4 family FAD_binding_2 PF00890.24 EGD95262.1 - 0.057 12.5 0.0 0.1 11.7 0.0 1.4 1 0 0 1 1 1 0 FAD binding domain Pyr_redox PF00070.27 EGD95262.1 - 0.22 12.1 0.0 0.51 10.9 0.0 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Aldedh PF00171.22 EGD95263.1 - 2.1e-160 534.3 0.3 2.5e-160 534.0 0.3 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Wtap PF17098.5 EGD95263.1 - 0.0087 16.0 0.0 0.018 15.0 0.0 1.4 1 0 0 1 1 1 1 WTAP/Mum2p family Glucosamine_iso PF01182.20 EGD95264.1 - 3.2e-23 82.8 0.0 4.9e-23 82.2 0.0 1.3 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase Glyco_hydro_3 PF00933.21 EGD95265.1 - 3.6e-67 227.0 0.0 5.2e-67 226.5 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.22 EGD95265.1 - 1e-06 28.9 0.4 2.1e-06 27.8 0.0 1.7 2 0 0 2 2 2 1 Glycosyl hydrolase family 3 C-terminal domain Acetyltransf_1 PF00583.25 EGD95265.1 - 3.2e-05 24.1 0.0 9.4e-05 22.6 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EGD95265.1 - 0.015 15.2 0.0 0.037 14.0 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain FR47 PF08445.10 EGD95265.1 - 0.022 14.7 0.0 0.11 12.5 0.0 2.2 1 0 0 1 1 1 0 FR47-like protein Acetyltransf_7 PF13508.7 EGD95265.1 - 0.068 13.6 0.0 0.2 12.1 0.0 1.7 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain NDT80_PhoG PF05224.12 EGD95266.1 - 5.4e-33 114.8 3.2 6.1e-33 114.6 0.0 2.5 3 0 0 3 3 3 1 NDT80 / PhoG like DNA-binding family KRTAP PF11759.8 EGD95266.1 - 0.074 13.6 6.0 0.14 12.7 6.0 1.4 1 0 0 1 1 1 0 Keratin-associated matrix TFIIA PF03153.13 EGD95266.1 - 0.94 9.4 20.4 1.7 8.6 11.0 2.2 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Keratin_2_head PF16208.5 EGD95266.1 - 1.6 8.9 13.3 0.2 11.8 7.8 2.1 2 0 0 2 2 2 0 Keratin type II head Hexokinase_2 PF03727.16 EGD95267.1 - 9.6e-54 182.3 0.0 1.7e-53 181.5 0.0 1.4 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 EGD95267.1 - 2.6e-46 158.1 0.0 4e-46 157.5 0.0 1.3 1 0 0 1 1 1 1 Hexokinase p450 PF00067.22 EGD95268.1 - 2.8e-58 197.8 0.0 3.5e-58 197.5 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Emaravirus_P4 PF16505.5 EGD95268.1 - 0.21 10.6 0.0 0.34 9.9 0.0 1.2 1 0 0 1 1 1 0 P4 movement protein of Emaravirus, and the 30K superfamily Hep_59 PF07052.11 EGD95269.1 - 4.6e-19 69.1 0.1 4.6e-19 69.1 0.1 2.4 3 1 0 3 3 3 1 Hepatocellular carcinoma-associated antigen 59 CRT10 PF08728.10 EGD95272.1 - 0.0034 15.6 0.9 0.0039 15.4 0.9 1.0 1 0 0 1 1 1 1 CRT10 JHD PF17811.1 EGD95272.1 - 0.019 15.5 9.9 0.11 13.0 1.2 2.2 1 1 1 2 2 2 0 Jumonji helical domain DUF3074 PF11274.8 EGD95272.1 - 0.81 9.6 3.4 1.8 8.5 3.4 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3074) HAUS-augmin3 PF14932.6 EGD95272.1 - 1.8 8.1 15.6 2.8 7.4 15.6 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 V_ATPase_I PF01496.19 EGD95272.1 - 3.3 5.5 7.2 4.1 5.2 7.2 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Helicase_IV_N PF12462.8 EGD95272.1 - 6.8 6.6 10.5 0.32 10.9 3.9 1.9 2 0 0 2 2 2 0 DNA helicase IV / RNA helicase N terminal TRP PF06011.12 EGD95273.1 - 1.2e-138 462.4 9.2 1.6e-138 462.0 9.2 1.1 1 0 0 1 1 1 1 Transient receptor potential (TRP) ion channel TRP_N PF14558.6 EGD95273.1 - 4.3e-31 108.1 0.2 6.7e-31 107.5 0.2 1.3 1 0 0 1 1 1 1 ML-like domain RseC_MucC PF04246.12 EGD95273.1 - 5.7 6.9 10.0 5.4 7.0 0.8 3.1 3 0 0 3 3 3 0 Positive regulator of sigma(E), RseC/MucC TFIIIC_sub6 PF10419.9 EGD95274.1 - 4.8e-08 32.8 0.0 8.6e-08 32.0 0.0 1.4 1 0 0 1 1 1 1 TFIIIC subunit triple barrel domain GATA PF00320.27 EGD95274.1 - 0.088 12.4 0.3 0.16 11.6 0.3 1.4 1 0 0 1 1 1 0 GATA zinc finger INTS2 PF14750.6 EGD95275.1 - 0.052 11.1 0.1 0.07 10.7 0.1 1.1 1 0 0 1 1 1 0 Integrator complex subunit 2 FAM70 PF14967.6 EGD95275.1 - 3.3 7.1 7.5 3.9 6.8 7.5 1.1 1 0 0 1 1 1 0 FAM70 protein MFS_1 PF07690.16 EGD95278.1 - 4.1e-50 170.7 46.7 2.8e-45 154.8 48.8 2.6 2 1 0 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 EGD95278.1 - 2e-10 39.7 10.1 2e-10 39.7 10.1 2.3 1 1 1 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Myb_DNA-binding PF00249.31 EGD95280.1 - 1e-31 108.9 8.7 1.3e-11 44.5 0.7 3.2 3 0 0 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EGD95280.1 - 6.2e-31 106.4 3.4 8.3e-15 54.8 1.8 3.2 1 1 2 3 3 3 3 Myb-like DNA-binding domain SANT_DAMP1_like PF16282.5 EGD95280.1 - 7.2e-05 22.9 1.2 0.065 13.4 0.2 2.9 2 1 1 3 3 3 2 SANT/Myb-like domain of DAMP1 Myb_DNA-bind_7 PF15963.5 EGD95280.1 - 0.00088 19.1 0.3 0.92 9.4 0.0 2.6 2 1 1 3 3 3 2 Myb DNA-binding like Rap1_C PF11626.8 EGD95280.1 - 0.021 14.9 1.6 3.5 7.8 1.2 2.6 1 1 0 1 1 1 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain SLIDE PF09111.10 EGD95280.1 - 0.16 12.0 0.1 18 5.4 0.0 3.0 1 1 2 3 3 3 0 SLIDE RAP80_UIM PF18282.1 EGD95280.1 - 0.22 11.3 0.6 0.43 10.4 0.1 1.7 2 0 0 2 2 2 0 RAP80 N-terminal ubiquitin interaction motif PPR_2 PF13041.6 EGD95281.1 - 7.4e-11 42.1 0.3 0.021 15.0 0.0 6.7 5 3 2 7 7 7 2 PPR repeat family PPR PF01535.20 EGD95281.1 - 2e-07 30.8 5.2 0.65 10.4 0.0 7.5 8 0 0 8 8 8 1 PPR repeat DDT PF02791.17 EGD95281.1 - 0.01 16.1 0.5 0.18 12.1 0.1 2.9 2 0 0 2 2 2 0 DDT domain TPR_14 PF13428.6 EGD95281.1 - 0.011 16.5 0.0 23 6.1 0.0 5.4 6 0 0 6 6 6 0 Tetratricopeptide repeat T2SS_PulS_OutS PF09691.10 EGD95281.1 - 0.12 12.6 0.3 7.2 6.8 0.1 2.4 2 0 0 2 2 2 0 Type II secretion system pilotin lipoprotein (PulS_OutS) PPR_3 PF13812.6 EGD95281.1 - 0.62 10.2 2.9 16 5.7 0.0 4.3 6 0 0 6 6 6 0 Pentatricopeptide repeat domain Ribosomal_S18 PF01084.20 EGD95282.1 - 4e-16 58.9 0.2 7.6e-16 58.1 0.2 1.4 1 0 0 1 1 1 1 Ribosomal protein S18 Cro PF09048.10 EGD95282.1 - 0.013 15.5 0.0 0.025 14.6 0.0 1.4 1 0 0 1 1 1 0 Cro WD40 PF00400.32 EGD95283.1 - 9.6e-36 121.2 26.9 5.4e-05 23.9 0.3 11.0 11 0 0 11 11 11 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EGD95283.1 - 2.9e-19 69.2 4.8 4.2e-05 23.8 0.0 6.4 4 2 3 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 EGD95283.1 - 0.0012 18.8 1.0 24 5.0 0.0 5.2 5 0 0 5 5 5 1 WD40-like Beta Propeller Repeat BBS2_N PF14781.6 EGD95283.1 - 0.0013 18.7 0.0 0.033 14.1 0.0 2.6 2 0 0 2 2 2 1 Ciliary BBSome complex subunit 2, N-terminal Ge1_WD40 PF16529.5 EGD95283.1 - 0.0014 17.6 0.2 20 4.0 0.0 4.5 4 2 0 4 4 4 1 WD40 region of Ge1, enhancer of mRNA-decapping protein IRF PF00605.17 EGD95283.1 - 0.23 11.8 1.4 16 5.9 0.2 2.5 2 0 0 2 2 2 0 Interferon regulatory factor transcription factor Peptidase_M36 PF02128.15 EGD95287.1 - 5e-156 519.5 4.2 6.3e-156 519.2 4.2 1.1 1 0 0 1 1 1 1 Fungalysin metallopeptidase (M36) FTP PF07504.13 EGD95287.1 - 1.8e-18 66.1 4.1 3.5e-18 65.2 4.1 1.5 1 0 0 1 1 1 1 Fungalysin/Thermolysin Propeptide Motif Peptidase_M4_C PF02868.15 EGD95287.1 - 0.07 13.0 0.0 0.17 11.7 0.0 1.6 1 0 0 1 1 1 0 Thermolysin metallopeptidase, alpha-helical domain MFS_1 PF07690.16 EGD95289.1 - 3.3e-26 92.1 38.8 3.3e-26 92.1 38.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Pex14_N PF04695.13 EGD95289.1 - 0.055 14.1 0.5 0.13 12.9 0.5 1.6 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF3328 PF11807.8 EGD95290.1 - 1.4e-22 80.6 0.1 2e-22 80.1 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) Ycf9 PF01737.17 EGD95290.1 - 0.03 14.2 0.0 0.051 13.5 0.0 1.3 1 0 0 1 1 1 0 YCF9 DUF4869 PF16163.5 EGD95291.1 - 0.14 11.8 0.3 0.18 11.5 0.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4869) DIM PF08194.12 EGD95291.1 - 0.43 10.8 1.3 0.6 10.3 1.3 1.3 1 0 0 1 1 1 0 DIM protein CitT PF12431.8 EGD95291.1 - 1.3 9.5 3.6 32 5.0 0.3 2.5 2 0 0 2 2 2 0 Transcriptional regulator DUF3328 PF11807.8 EGD95292.1 - 4e-22 79.1 0.1 5.2e-22 78.7 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) DUF3328 PF11807.8 EGD95293.1 - 2.9e-40 138.4 2.1 3.5e-40 138.1 2.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) Methyltransf_2 PF00891.18 EGD95294.1 - 1.4e-20 73.5 0.1 2.2e-20 72.9 0.1 1.4 1 1 0 1 1 1 1 O-methyltransferase domain CDC37_M PF08565.11 EGD95294.1 - 0.083 12.8 0.0 0.22 11.5 0.0 1.7 1 0 0 1 1 1 0 Cdc37 Hsp90 binding domain Carb_anhydrase PF00194.21 EGD95297.1 - 2.3e-33 115.8 0.0 3.8e-33 115.1 0.0 1.3 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase CA_like PF10563.9 EGD95297.1 - 0.018 15.0 0.3 0.1 12.5 0.1 2.1 1 1 1 2 2 2 0 Putative carbonic anhydrase Cu-oxidase_3 PF07732.15 EGD95297.1 - 0.11 12.5 0.0 0.22 11.6 0.0 1.4 1 0 0 1 1 1 0 Multicopper oxidase Alk_phosphatase PF00245.20 EGD95299.1 - 5.9e-107 358.2 0.0 7.1e-107 357.9 0.0 1.1 1 0 0 1 1 1 1 Alkaline phosphatase Metalloenzyme PF01676.18 EGD95299.1 - 8.5e-07 28.6 0.0 4.3e-06 26.3 0.0 1.9 2 0 0 2 2 2 1 Metalloenzyme superfamily FUSC_2 PF13515.6 EGD95300.1 - 2.4e-31 108.5 11.0 2.4e-31 108.5 11.0 2.4 2 0 0 2 2 2 1 Fusaric acid resistance protein-like FUSC PF04632.12 EGD95300.1 - 1.2e-05 24.1 18.0 8e-05 21.4 15.1 2.9 2 1 0 2 2 2 1 Fusaric acid resistance protein family ArAE_2 PF10334.9 EGD95300.1 - 0.00028 20.8 0.4 0.00059 19.7 0.4 1.5 1 0 0 1 1 1 1 Aromatic acid exporter family member 2 ALMT PF11744.8 EGD95300.1 - 0.017 14.0 24.6 0.057 12.2 11.5 3.5 3 2 0 3 3 3 0 Aluminium activated malate transporter TraS PF10624.9 EGD95300.1 - 0.089 12.7 1.9 5.9 6.8 0.7 2.6 2 0 0 2 2 2 0 Plasmid conjugative transfer entry exclusion protein TraS YajC PF02699.15 EGD95300.1 - 0.11 12.4 0.2 0.32 10.9 0.2 1.7 1 0 0 1 1 1 0 Preprotein translocase subunit SAGA-Tad1 PF12767.7 EGD95301.1 - 4.2e-54 183.8 0.0 5.5e-54 183.4 0.0 1.2 1 0 0 1 1 1 1 Transcriptional regulator of RNA polII, SAGA, subunit PRP1_N PF06424.12 EGD95302.1 - 1.5e-53 181.2 7.5 3.9e-53 179.8 7.5 1.7 1 0 0 1 1 1 1 PRP1 splicing factor, N-terminal TPR_14 PF13428.6 EGD95302.1 - 6.1e-29 98.2 26.6 0.0038 17.9 0.1 14.4 5 4 10 15 15 14 7 Tetratricopeptide repeat TPR_19 PF14559.6 EGD95302.1 - 4.7e-26 91.1 7.2 1.2e-06 29.0 0.1 9.7 6 3 2 9 9 9 3 Tetratricopeptide repeat TPR_2 PF07719.17 EGD95302.1 - 3.6e-10 39.2 9.8 0.27 11.4 0.0 8.9 10 0 0 10 10 9 2 Tetratricopeptide repeat TPR_8 PF13181.6 EGD95302.1 - 1.3e-08 34.3 3.0 0.093 13.0 0.0 7.8 10 0 0 10 10 9 2 Tetratricopeptide repeat TPR_17 PF13431.6 EGD95302.1 - 1.4e-08 34.5 1.7 2.6 8.6 0.0 8.9 9 0 0 9 9 8 1 Tetratricopeptide repeat TPR_16 PF13432.6 EGD95302.1 - 5.7e-07 30.1 14.1 0.22 12.2 0.0 7.7 7 1 1 8 8 8 1 Tetratricopeptide repeat NARP1 PF12569.8 EGD95302.1 - 7.2e-07 28.5 8.4 0.0099 14.8 0.0 5.5 3 1 3 6 6 6 1 NMDA receptor-regulated protein 1 TPR_9 PF13371.6 EGD95302.1 - 1e-05 25.6 3.8 0.043 14.0 0.1 4.6 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_11 PF13414.6 EGD95302.1 - 0.00016 21.3 1.3 33 4.3 0.0 6.7 7 1 1 8 8 8 0 TPR repeat TPR_1 PF00515.28 EGD95302.1 - 0.00024 20.8 1.6 0.88 9.5 0.0 4.7 5 0 0 5 5 5 1 Tetratricopeptide repeat ZNRF_3_ecto PF18212.1 EGD95302.1 - 0.011 15.8 0.2 35 4.5 0.0 4.6 6 0 0 6 6 6 0 ZNRF-3 Ectodomain TPR_12 PF13424.6 EGD95302.1 - 0.026 14.8 5.8 20 5.6 0.1 6.3 7 1 0 7 7 7 0 Tetratricopeptide repeat DUF3808 PF10300.9 EGD95302.1 - 0.097 11.4 0.3 3.4 6.3 0.0 3.4 3 1 0 4 4 4 0 Protein of unknown function (DUF3808) AdenylateSensor PF16579.5 EGD95302.1 - 0.11 12.9 0.5 24 5.4 0.0 3.7 3 1 1 4 4 4 0 Adenylate sensor of SNF1-like protein kinase TPR_7 PF13176.6 EGD95302.1 - 0.27 11.3 2.4 1.1e+02 3.2 0.0 4.8 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_21 PF09976.9 EGD95302.1 - 0.59 9.8 21.8 1.1 8.9 0.1 4.7 3 1 1 5 5 5 0 Tetratricopeptide repeat-like domain TPR_6 PF13174.6 EGD95302.1 - 6.9 7.5 12.8 53 4.8 0.0 6.9 9 0 0 9 9 6 0 Tetratricopeptide repeat RrnaAD PF00398.20 EGD95303.1 - 3.1e-64 216.6 0.0 4.5e-64 216.1 0.0 1.2 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_25 PF13649.6 EGD95303.1 - 1.9e-07 31.7 0.0 4e-07 30.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EGD95303.1 - 1.3e-05 25.7 0.0 3e-05 24.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 EGD95303.1 - 0.0001 22.1 0.0 0.00017 21.4 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) CMAS PF02353.20 EGD95303.1 - 0.00025 20.5 0.0 0.0004 19.8 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_12 PF08242.12 EGD95303.1 - 0.00097 19.8 0.0 0.0071 17.1 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 EGD95303.1 - 0.0011 18.9 0.0 0.002 18.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EGD95303.1 - 0.0012 18.5 0.0 0.0018 17.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Met_10 PF02475.16 EGD95303.1 - 0.012 15.3 0.0 0.022 14.5 0.0 1.4 1 0 0 1 1 1 0 Met-10+ like-protein PrmA PF06325.13 EGD95303.1 - 0.018 14.4 0.0 0.034 13.5 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_31 PF13847.6 EGD95303.1 - 0.021 14.6 0.0 0.036 13.9 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_2 PF00891.18 EGD95303.1 - 0.029 13.6 0.0 0.048 13.0 0.0 1.2 1 0 0 1 1 1 0 O-methyltransferase domain Ubie_methyltran PF01209.18 EGD95303.1 - 0.038 13.3 0.0 0.059 12.7 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_4 PF02390.17 EGD95303.1 - 0.045 13.2 0.0 0.1 12.0 0.0 1.6 1 0 0 1 1 1 0 Putative methyltransferase DREV PF05219.12 EGD95303.1 - 0.052 12.6 0.0 0.084 12.0 0.0 1.3 1 0 0 1 1 1 0 DREV methyltransferase Methyltransf_28 PF02636.17 EGD95303.1 - 0.054 13.1 0.0 0.09 12.4 0.0 1.3 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_18 PF12847.7 EGD95303.1 - 0.13 12.2 0.0 0.25 11.3 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain RabGAP-TBC PF00566.18 EGD95304.1 - 2.3e-51 174.5 0.0 9.5e-51 172.5 0.0 1.8 1 1 0 1 1 1 1 Rab-GTPase-TBC domain MCPVI PF02993.14 EGD95304.1 - 2.5 7.9 8.6 0.17 11.7 3.4 1.6 2 0 0 2 2 2 0 Minor capsid protein VI Herpes_pp85 PF04637.12 EGD95305.1 - 0.74 8.2 2.2 0.74 8.2 2.2 1.2 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) RRM_1 PF00076.22 EGD95306.1 - 1.7e-32 111.0 0.3 2.6e-15 56.0 0.1 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EGD95306.1 - 1.6e-09 37.8 0.3 0.00061 19.9 0.1 3.0 2 1 0 2 2 2 2 RNA recognition motif RRM_3 PF08777.11 EGD95306.1 - 0.0038 17.2 0.6 2.2 8.4 0.0 2.8 3 0 0 3 3 3 2 RNA binding motif Nup35_RRM_2 PF14605.6 EGD95306.1 - 0.016 15.2 0.0 5 7.2 0.0 2.3 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif Phytochelatin PF05023.14 EGD95306.1 - 0.072 12.3 0.8 1.3 8.2 0.0 2.7 3 0 0 3 3 3 0 Phytochelatin synthase MCRS_N PF13325.6 EGD95306.1 - 0.57 10.2 2.3 1.2 9.1 2.3 1.5 1 0 0 1 1 1 0 N-terminal region of micro-spherule protein LOH1CR12 PF10158.9 EGD95306.1 - 0.74 9.8 4.2 2.1 8.4 4.2 1.7 1 0 0 1 1 1 0 Tumour suppressor protein JmjC PF02373.22 EGD95308.1 - 5.2e-09 36.5 0.0 6.7e-08 32.9 0.0 2.5 1 1 0 1 1 1 1 JmjC domain, hydroxylase PHD PF00628.29 EGD95308.1 - 4.7e-08 32.8 8.0 4.7e-08 32.8 8.0 2.5 3 0 0 3 3 3 1 PHD-finger Cupin_8 PF13621.6 EGD95308.1 - 5.9e-08 32.7 0.0 1.6e-07 31.3 0.0 1.7 1 0 0 1 1 1 1 Cupin-like domain JHD PF17811.1 EGD95308.1 - 1.3e-06 28.9 0.3 2.4e-06 28.0 0.3 1.4 1 0 0 1 1 1 1 Jumonji helical domain PHD_2 PF13831.6 EGD95308.1 - 2.4 7.8 9.8 1.9 8.1 7.5 2.1 2 0 0 2 2 2 0 PHD-finger COG4 PF08318.12 EGD95309.1 - 5e-124 413.7 0.0 6.5e-124 413.4 0.0 1.2 1 0 0 1 1 1 1 COG4 transport protein SIR2 PF02146.17 EGD95310.1 - 1.6e-56 191.0 0.0 2.4e-56 190.5 0.0 1.3 1 0 0 1 1 1 1 Sir2 family TPP_enzyme_M PF00205.22 EGD95310.1 - 0.095 12.4 0.0 0.56 10.0 0.0 2.1 2 0 0 2 2 2 0 Thiamine pyrophosphate enzyme, central domain Hexokinase_2 PF03727.16 EGD95311.1 - 1e-81 273.9 0.0 1.4e-81 273.4 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 EGD95311.1 - 2.7e-72 242.8 0.0 3.6e-72 242.5 0.0 1.1 1 0 0 1 1 1 1 Hexokinase ANAPC4_WD40 PF12894.7 EGD95312.1 - 0.00016 21.9 0.1 0.61 10.4 0.2 4.0 4 1 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EGD95312.1 - 0.0013 19.5 4.9 1.3 10.1 0.0 5.1 6 0 0 6 6 6 1 WD domain, G-beta repeat SGL PF08450.12 EGD95312.1 - 0.015 14.9 0.2 0.17 11.4 0.0 2.1 1 1 1 2 2 2 0 SMP-30/Gluconolactonase/LRE-like region PikAIV_N PF18605.1 EGD95312.1 - 0.23 11.0 5.8 2.3 7.9 0.7 2.9 3 0 0 3 3 3 0 Narbonolide/10-deoxymethynolide synthase PikA4 N-terminal domain STIMATE PF12400.8 EGD95313.1 - 1e-37 129.5 7.0 1.8e-37 128.6 7.0 1.4 1 0 0 1 1 1 1 STIMATE family Mucin PF01456.17 EGD95313.1 - 3.5 7.6 19.8 6.3 6.8 19.8 1.3 1 0 0 1 1 1 0 Mucin-like glycoprotein RRM_1 PF00076.22 EGD95314.1 - 3.7e-19 68.3 0.3 5.6e-19 67.7 0.3 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EGD95314.1 - 5e-06 26.1 0.0 5.3e-06 26.0 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EGD95314.1 - 0.0021 17.9 0.0 0.0032 17.3 0.0 1.2 1 0 0 1 1 1 1 Occluded RNA-recognition motif Ammonium_transp PF00909.21 EGD95315.1 - 3.2e-115 385.0 28.8 3.7e-115 384.8 28.8 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family E1-E2_ATPase PF00122.20 EGD95316.1 - 3.3e-46 157.1 0.3 3.3e-46 157.1 0.3 2.0 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 EGD95316.1 - 1.2e-44 152.2 0.2 1.2e-44 152.2 0.2 2.2 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Cation_ATPase_N PF00690.26 EGD95316.1 - 9.6e-22 76.5 0.0 2.6e-21 75.1 0.0 1.8 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase PF00702.26 EGD95316.1 - 9.3e-21 75.1 2.8 1.3e-19 71.4 2.8 2.6 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EGD95316.1 - 1.3e-11 44.4 0.0 2.8e-11 43.3 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 EGD95316.1 - 2e-05 24.5 1.7 0.00038 20.3 0.9 2.3 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Rad21_Rec8_N PF04825.13 EGD95317.1 - 1.3e-37 128.3 0.0 2.3e-37 127.5 0.0 1.4 1 0 0 1 1 1 1 N terminus of Rad21 / Rec8 like protein Rad21_Rec8 PF04824.16 EGD95317.1 - 3.2e-07 29.5 0.3 6.9e-07 28.5 0.3 1.5 1 0 0 1 1 1 1 Conserved region of Rad21 / Rec8 like protein Zn_clus PF00172.18 EGD95321.1 - 0.0035 17.4 9.0 0.0035 17.4 9.0 1.7 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PAS PF00989.25 EGD95321.1 - 0.039 14.0 0.0 0.081 12.9 0.0 1.5 1 0 0 1 1 1 0 PAS fold Flavokinase PF01687.17 EGD95323.1 - 3.1e-31 107.9 0.0 4.3e-31 107.5 0.0 1.1 1 0 0 1 1 1 1 Riboflavin kinase RSN1_7TM PF02714.15 EGD95324.1 - 4.8e-85 285.2 28.9 4.8e-85 285.2 28.9 1.8 3 0 0 3 3 3 1 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 EGD95324.1 - 5.6e-47 159.4 1.0 5.6e-47 159.4 1.0 3.7 3 1 1 4 4 4 1 Late exocytosis, associated with Golgi transport PHM7_cyt PF14703.6 EGD95324.1 - 5.8e-25 88.5 4.9 1.1e-23 84.4 4.9 2.4 1 1 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter PHM7_ext PF12621.8 EGD95324.1 - 6.5e-14 51.9 1.0 1.5e-13 50.7 0.0 2.1 2 0 0 2 2 2 1 Extracellular tail, of 10TM putative phosphate transporter VCX_VCY PF15231.6 EGD95325.1 - 0.17 12.6 2.0 0.23 12.2 2.0 1.2 1 0 0 1 1 1 0 Variable charge X/Y family SnoaL_2 PF12680.7 EGD95326.1 - 1.5e-06 28.8 0.0 2.6e-06 28.0 0.0 1.4 1 0 0 1 1 1 1 SnoaL-like domain SnoaL PF07366.12 EGD95326.1 - 0.00019 21.3 0.0 0.00034 20.4 0.0 1.4 1 0 0 1 1 1 1 SnoaL-like polyketide cyclase DLH PF01738.18 EGD95326.1 - 0.043 13.3 0.0 1.3 8.5 0.0 2.4 2 1 1 3 3 3 0 Dienelactone hydrolase family Indigoidine_A PF04227.12 EGD95327.1 - 2e-123 411.4 0.6 2.8e-123 411.0 0.6 1.2 1 0 0 1 1 1 1 Indigoidine synthase A like protein PfkB PF00294.24 EGD95327.1 - 2.8e-13 49.9 0.0 1.6e-07 30.9 0.0 3.2 2 1 0 2 2 2 2 pfkB family carbohydrate kinase Ribophorin_I PF04597.14 EGD95328.1 - 4.1e-143 477.8 0.2 4.6e-143 477.6 0.2 1.0 1 0 0 1 1 1 1 Ribophorin I VTC PF09359.10 EGD95329.1 - 7.1e-100 333.9 0.4 1e-99 333.4 0.4 1.2 1 0 0 1 1 1 1 VTC domain SPX PF03105.19 EGD95329.1 - 7.5e-15 55.7 4.8 7.5e-06 26.1 0.0 3.4 2 1 1 3 3 3 3 SPX domain DUF202 PF02656.15 EGD95329.1 - 2.5e-11 43.8 3.6 2.5e-11 43.8 3.6 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF202) MCM PF00493.23 EGD95330.1 - 1.7e-102 341.3 0.0 2.5e-102 340.7 0.0 1.2 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 EGD95330.1 - 9.6e-37 125.6 0.3 1.9e-36 124.7 0.3 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 EGD95330.1 - 1.3e-28 99.2 2.3 3.1e-28 98.0 2.3 1.7 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 EGD95330.1 - 9.9e-19 67.9 0.0 3.2e-18 66.2 0.0 2.0 2 0 0 2 2 2 1 MCM N-terminal domain Mg_chelatase PF01078.21 EGD95330.1 - 7.6e-06 25.4 0.0 0.00027 20.4 0.0 2.4 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 EGD95330.1 - 1.6e-05 25.0 0.1 0.00011 22.2 0.0 2.6 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 EGD95330.1 - 0.0026 17.6 0.0 0.011 15.6 0.0 2.1 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_32 PF13654.6 EGD95330.1 - 8.1 5.1 6.7 1.1 8.0 0.7 2.1 2 0 0 2 2 2 0 AAA domain Ank_2 PF12796.7 EGD95331.1 - 0.0018 18.8 0.1 0.31 11.6 0.1 2.4 1 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 EGD95331.1 - 0.0097 16.3 0.0 0.034 14.6 0.0 2.0 2 0 0 2 2 2 1 Ankyrin repeat Ank_4 PF13637.6 EGD95331.1 - 0.022 15.3 0.0 1.5 9.5 0.0 2.5 2 0 0 2 2 2 0 Ankyrin repeats (many copies) HeLo PF14479.6 EGD95332.1 - 2e-09 37.6 0.0 2.8e-09 37.1 0.0 1.4 1 0 0 1 1 1 1 Prion-inhibition and propagation Band_7 PF01145.25 EGD95333.1 - 1.7e-22 80.3 6.2 2.9e-22 79.5 6.2 1.4 1 1 0 1 1 1 1 SPFH domain / Band 7 family CSTF2_hinge PF14327.6 EGD95334.1 - 2.4e-32 111.2 2.5 2.4e-32 111.2 2.5 2.2 3 0 0 3 3 3 1 Hinge domain of cleavage stimulation factor subunit 2 RRM_1 PF00076.22 EGD95334.1 - 7e-20 70.6 0.0 1.2e-19 69.8 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CSTF_C PF14304.6 EGD95334.1 - 4.7e-18 64.5 8.8 2.2e-17 62.4 8.8 2.3 1 0 0 1 1 1 1 Transcription termination and cleavage factor C-terminal RRM_7 PF16367.5 EGD95334.1 - 0.01 15.9 0.1 1 9.5 0.0 2.4 1 1 1 2 2 2 0 RNA recognition motif Spo7_2_N PF15407.6 EGD95334.1 - 0.014 15.0 0.0 0.027 14.1 0.0 1.4 1 0 0 1 1 1 0 Sporulation protein family 7 RRM_Rrp7 PF17799.1 EGD95334.1 - 0.022 14.6 0.0 2.2 8.1 0.0 2.3 1 1 1 2 2 2 0 Rrp7 RRM-like N-terminal domain RRM_occluded PF16842.5 EGD95334.1 - 0.06 13.2 0.0 0.2 11.5 0.0 1.8 1 1 0 1 1 1 0 Occluded RNA-recognition motif MCCD1 PF15707.5 EGD95334.1 - 0.54 10.7 4.1 0.55 10.7 0.4 2.3 2 0 0 2 2 2 0 Mitochondrial coiled-coil domain protein 1 SNF2_N PF00176.23 EGD95335.1 - 3.6e-22 78.6 0.1 7.3e-21 74.3 0.1 2.2 1 1 0 1 1 1 1 SNF2 family N-terminal domain DNA_methylase PF00145.17 EGD95335.1 - 7.2e-19 68.3 0.0 1.4e-18 67.4 0.0 1.4 1 0 0 1 1 1 1 C-5 cytosine-specific DNA methylase Helicase_C PF00271.31 EGD95335.1 - 6.1e-05 23.3 0.0 0.00052 20.3 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain zf-RING_UBOX PF13445.6 EGD95335.1 - 0.52 10.4 15.5 0.48 10.5 5.9 2.9 2 0 0 2 2 2 0 RING-type zinc-finger zf-RING_5 PF14634.6 EGD95335.1 - 0.95 9.5 23.9 0.46 10.5 11.7 2.8 2 0 0 2 2 2 0 zinc-RING finger domain zf-C3HC4_2 PF13923.6 EGD95335.1 - 9.6 6.2 19.2 3.4 7.6 6.7 2.8 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) 2Fe-2S_thioredx PF01257.19 EGD95336.1 - 5.6e-59 198.1 0.1 7.1e-59 197.8 0.1 1.1 1 0 0 1 1 1 1 Thioredoxin-like [2Fe-2S] ferredoxin DUF4139 PF13598.6 EGD95337.1 - 7e-21 74.9 0.5 1.4e-16 60.8 0.0 3.1 2 1 0 2 2 2 1 Domain of unknown function (DUF4139) DUF4140 PF13600.6 EGD95337.1 - 1.9e-15 57.1 9.4 1.9e-15 57.1 9.4 3.0 1 1 1 2 2 2 1 N-terminal domain of unknown function (DUF4140) AAA_13 PF13166.6 EGD95337.1 - 0.089 11.4 7.0 0.13 10.9 7.0 1.1 1 0 0 1 1 1 0 AAA domain V_ATPase_I PF01496.19 EGD95337.1 - 0.39 8.6 6.6 0.58 8.0 6.6 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Nucleoporin_FG PF13634.6 EGD95337.1 - 0.45 11.4 6.0 1.2 10.1 6.0 1.6 1 0 0 1 1 1 0 Nucleoporin FG repeat region RR_TM4-6 PF06459.12 EGD95337.1 - 0.56 10.0 8.1 1.1 9.0 8.1 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 YhzD PF14120.6 EGD95337.1 - 4.4 7.5 6.0 11 6.2 6.0 1.6 1 0 0 1 1 1 0 YhzD-like protein Atg14 PF10186.9 EGD95337.1 - 4.7 6.2 6.9 10 5.1 6.9 1.5 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 UPF0242 PF06785.11 EGD95337.1 - 6.6 6.8 12.3 11 6.1 12.3 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Sua5_yciO_yrdC PF01300.18 EGD95338.1 - 3.3e-54 183.1 0.0 5.3e-54 182.4 0.0 1.3 1 0 0 1 1 1 1 Telomere recombination SUA5 PF03481.13 EGD95338.1 - 5.2e-32 111.2 0.0 9.4e-32 110.4 0.0 1.4 1 0 0 1 1 1 1 Putative GTP-binding controlling metal-binding NFACT-C PF11923.8 EGD95339.1 - 1.4e-36 124.6 0.0 1.4e-36 124.6 0.0 3.6 5 0 0 5 5 5 1 NFACT protein C-terminal domain FbpA PF05833.11 EGD95339.1 - 1.2e-33 116.6 9.2 2.2e-33 115.7 9.2 1.4 1 0 0 1 1 1 1 Fibronectin-binding protein A N-terminus (FbpA) NFACT-R_1 PF05670.13 EGD95339.1 - 9.3e-28 97.1 0.0 2e-27 96.0 0.0 1.6 1 0 0 1 1 1 1 NFACT protein RNA binding domain Clat_adaptor_s PF01217.20 EGD95340.1 - 6e-14 52.2 0.0 1.3e-12 47.8 0.1 2.0 2 0 0 2 2 2 2 Clathrin adaptor complex small chain PAG PF15347.6 EGD95341.1 - 0.012 14.7 0.1 0.015 14.3 0.1 1.2 1 0 0 1 1 1 0 Phosphoprotein associated with glycosphingolipid-enriched TLE_N PF03920.15 EGD95341.1 - 0.06 13.4 0.3 0.11 12.5 0.3 1.4 1 0 0 1 1 1 0 Groucho/TLE N-terminal Q-rich domain DUF948 PF06103.11 EGD95342.1 - 0.031 14.5 1.2 0.072 13.4 1.2 1.6 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) DUF1515 PF07439.11 EGD95342.1 - 0.13 12.3 10.5 0.035 14.1 4.0 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1515) TTKRSYEDQ PF10212.9 EGD95342.1 - 0.27 10.2 9.6 0.06 12.3 5.3 1.8 2 0 0 2 2 2 0 Predicted coiled-coil domain-containing protein DUF4407 PF14362.6 EGD95342.1 - 0.7 9.2 12.4 1.8 7.9 12.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Bacillus_HBL PF05791.11 EGD95342.1 - 1.5 8.6 7.7 0.62 9.9 3.8 2.1 1 1 1 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) Laminin_II PF06009.12 EGD95342.1 - 2.2 8.3 10.9 7.1 6.6 10.9 1.9 1 0 0 1 1 1 0 Laminin Domain II DUF1664 PF07889.12 EGD95342.1 - 2.5 8.1 6.8 1.5 8.9 4.0 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) FlaC_arch PF05377.11 EGD95342.1 - 2.8 8.4 11.8 12 6.4 0.3 4.2 3 1 1 4 4 4 0 Flagella accessory protein C (FlaC) MPS2 PF17060.5 EGD95342.1 - 7.9 5.6 12.2 15 4.7 12.2 1.5 1 0 0 1 1 1 0 Monopolar spindle protein 2 FapA PF03961.13 EGD95342.1 - 8.4 4.9 9.7 19 3.7 9.7 1.6 1 0 0 1 1 1 0 Flagellar Assembly Protein A Pyridoxal_deC PF00282.19 EGD95343.1 - 1.1e-17 63.8 0.0 2.2e-08 33.2 0.0 3.2 3 0 0 3 3 3 3 Pyridoxal-dependent decarboxylase conserved domain Ribosomal_L16 PF00252.18 EGD95344.1 - 4.1e-43 146.6 0.1 5.6e-43 146.1 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e Lambda_CIII PF02061.16 EGD95345.1 - 0.077 13.1 0.1 6.4 6.9 0.0 2.6 2 0 0 2 2 2 0 Lambda Phage CIII Retrotran_gag_2 PF14223.6 EGD95346.1 - 0.0053 16.4 0.0 0.015 15.0 0.0 1.7 2 0 0 2 2 2 1 gag-polypeptide of LTR copia-type FAD_binding_2 PF00890.24 EGD95347.1 - 5.4e-84 282.7 0.2 7.4e-84 282.2 0.2 1.2 1 0 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.7 EGD95347.1 - 6.5e-10 38.9 3.3 1.9e-08 34.1 1.4 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase DAO PF01266.24 EGD95347.1 - 6e-09 35.9 2.9 1.9e-08 34.3 2.9 1.9 1 1 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 EGD95347.1 - 6.1e-08 32.3 0.2 0.0027 17.0 0.6 2.2 2 0 0 2 2 2 2 FAD binding domain Pyr_redox_2 PF07992.14 EGD95347.1 - 3.6e-06 26.4 0.1 4.9e-05 22.7 0.1 2.3 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EGD95347.1 - 1e-05 25.7 3.6 2.8e-05 24.2 3.6 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 EGD95347.1 - 1.1e-05 24.3 2.0 1.9e-05 23.6 0.3 1.9 2 0 0 2 2 2 1 HI0933-like protein Thi4 PF01946.17 EGD95347.1 - 5.4e-05 22.6 1.7 6.1e-05 22.4 0.6 1.6 2 0 0 2 2 2 1 Thi4 family Pyr_redox_3 PF13738.6 EGD95347.1 - 0.0015 17.8 0.4 0.0026 17.1 0.2 1.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase UPF0227 PF05728.12 EGD95347.1 - 0.093 12.7 0.0 0.16 11.9 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0227) GIDA PF01134.22 EGD95347.1 - 0.16 11.1 0.7 0.28 10.2 0.7 1.4 1 0 0 1 1 1 0 Glucose inhibited division protein A AAA PF00004.29 EGD95348.1 - 2.4e-19 70.1 0.0 6.7e-19 68.6 0.0 1.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EGD95348.1 - 0.00012 22.6 0.4 0.0013 19.2 0.0 2.8 3 1 0 3 3 3 1 AAA ATPase domain AAA_5 PF07728.14 EGD95348.1 - 0.00053 20.0 0.0 0.0013 18.7 0.0 1.8 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.17 EGD95348.1 - 0.0039 16.9 0.0 0.0072 16.1 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_22 PF13401.6 EGD95348.1 - 0.0054 17.0 0.9 0.048 13.9 0.0 2.6 2 1 1 3 3 3 1 AAA domain AAA_18 PF13238.6 EGD95348.1 - 0.0073 16.9 0.0 0.045 14.3 0.0 2.4 2 0 0 2 2 2 1 AAA domain Sigma54_activat PF00158.26 EGD95348.1 - 0.014 15.1 0.0 0.43 10.3 0.0 2.2 2 0 0 2 2 2 0 Sigma-54 interaction domain Zot PF05707.12 EGD95348.1 - 0.017 14.7 0.1 0.12 12.1 0.0 2.1 1 1 0 2 2 2 0 Zonular occludens toxin (Zot) Mg_chelatase PF01078.21 EGD95348.1 - 0.041 13.3 0.0 0.095 12.1 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_2 PF07724.14 EGD95348.1 - 0.073 13.2 0.0 0.21 11.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) AAA_28 PF13521.6 EGD95348.1 - 0.08 13.2 0.0 0.21 11.8 0.0 1.9 1 0 0 1 1 1 0 AAA domain T2SSE PF00437.20 EGD95348.1 - 0.089 11.8 0.0 0.16 11.0 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein ATPase PF06745.13 EGD95348.1 - 0.2 11.0 0.0 0.4 10.0 0.0 1.5 1 0 0 1 1 1 0 KaiC FA_hydroxylase PF04116.13 EGD95349.1 - 2.5e-22 79.6 12.1 2.5e-22 79.6 12.1 1.7 2 1 0 2 2 2 1 Fatty acid hydroxylase superfamily HA2 PF04408.23 EGD95350.1 - 6.3e-21 74.7 0.0 6.3e-21 74.7 0.0 2.8 3 0 0 3 3 3 1 Helicase associated domain (HA2) Helicase_C PF00271.31 EGD95350.1 - 2.5e-12 47.1 0.0 6.4e-12 45.8 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain OB_NTP_bind PF07717.16 EGD95350.1 - 7.7e-12 45.4 0.0 2.4e-11 43.8 0.0 1.8 2 0 0 2 2 2 1 Oligonucleotide/oligosaccharide-binding (OB)-fold DEAD PF00270.29 EGD95350.1 - 0.00054 19.8 0.0 0.0015 18.3 0.0 1.7 1 1 0 1 1 1 1 DEAD/DEAH box helicase AAA_29 PF13555.6 EGD95350.1 - 0.0048 16.6 0.0 0.013 15.2 0.0 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_22 PF13401.6 EGD95350.1 - 0.032 14.5 0.0 0.11 12.8 0.0 1.9 1 1 0 1 1 1 0 AAA domain ATPase PF06745.13 EGD95350.1 - 0.1 12.0 0.0 0.19 11.1 0.0 1.3 1 0 0 1 1 1 0 KaiC ABC_tran PF00005.27 EGD95350.1 - 0.11 13.1 0.0 0.28 11.7 0.0 1.7 1 0 0 1 1 1 0 ABC transporter Zn_clus PF00172.18 EGD95351.1 - 4.3e-08 33.1 11.8 7.7e-08 32.3 11.8 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain RTA1 PF04479.13 EGD95352.1 - 1.6e-39 135.7 4.0 2.1e-39 135.3 4.0 1.1 1 0 0 1 1 1 1 RTA1 like protein Phosducin PF02114.16 EGD95353.1 - 0.15 10.9 0.0 0.2 10.6 0.0 1.2 1 0 0 1 1 1 0 Phosducin SAUGI PF06106.11 EGD95353.1 - 0.16 12.5 0.0 0.28 11.7 0.0 1.4 1 1 0 1 1 1 0 S. aureus uracil DNA glycosylase inhibitor Fungal_lectin PF07938.12 EGD95354.1 - 5.9e-144 479.0 0.2 6.7e-144 478.8 0.2 1.0 1 0 0 1 1 1 1 Fungal fucose-specific lectin TauD PF02668.16 EGD95355.1 - 7.8e-30 104.6 0.0 1.2e-29 104.0 0.0 1.2 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family TSSC4 PF15264.6 EGD95355.1 - 0.13 12.5 0.1 0.25 11.6 0.1 1.4 1 0 0 1 1 1 0 Tumour suppressing sub-chromosomal transferable candidate 4 GAGA PF09237.11 EGD95356.1 - 0.1 12.4 0.1 0.2 11.5 0.1 1.5 1 0 0 1 1 1 0 GAGA factor Complex1_LYR_2 PF13233.6 EGD95357.1 - 5.5e-20 71.9 0.0 7e-20 71.6 0.0 1.1 1 0 0 1 1 1 1 Complex1_LYR-like Complex1_LYR PF05347.15 EGD95357.1 - 3.7e-09 36.5 0.0 6.2e-09 35.8 0.0 1.3 1 0 0 1 1 1 1 Complex 1 protein (LYR family) MTS PF05175.14 EGD95358.1 - 0.0071 15.9 0.1 2.5 7.6 0.0 2.3 1 1 1 2 2 2 2 Methyltransferase small domain Methyltransf_12 PF08242.12 EGD95358.1 - 0.11 13.3 0.0 0.2 12.4 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_25 PF13649.6 EGD95358.1 - 0.2 12.4 0.0 0.36 11.5 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain LSM PF01423.22 EGD95359.1 - 4.2e-17 61.6 0.0 5.3e-17 61.3 0.0 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EGD95359.1 - 0.0043 17.2 0.0 0.0056 16.8 0.0 1.2 1 0 0 1 1 1 1 Ataxin 2 SM domain F-box-like PF12937.7 EGD95360.1 - 1e-05 25.3 1.6 3e-05 23.8 0.1 2.4 1 1 1 2 2 2 1 F-box-like F-box_4 PF15966.5 EGD95360.1 - 0.002 18.0 0.1 0.0042 17.0 0.1 1.4 1 0 0 1 1 1 1 F-box F-box PF00646.33 EGD95360.1 - 0.0074 16.1 0.1 0.022 14.6 0.1 1.9 1 0 0 1 1 1 1 F-box domain zf-C2H2 PF00096.26 EGD95362.1 - 1.4e-05 25.3 2.4 0.054 14.0 0.5 2.9 2 0 0 2 2 2 2 Zinc finger, C2H2 type Zn_ribbon_recom PF13408.6 EGD95362.1 - 0.06 13.9 0.4 0.14 12.7 0.4 1.6 1 0 0 1 1 1 0 Recombinase zinc beta ribbon domain zf-C2H2_4 PF13894.6 EGD95362.1 - 0.087 13.7 10.2 0.72 10.9 0.0 3.7 3 0 0 3 3 3 0 C2H2-type zinc finger FEZ PF07763.13 EGD95364.1 - 0.047 13.4 0.0 0.056 13.2 0.0 1.2 1 0 0 1 1 1 0 FEZ-like protein DUF936 PF06075.12 EGD95365.1 - 0.024 13.6 13.1 0.028 13.4 13.1 1.0 1 0 0 1 1 1 0 Plant protein of unknown function (DUF936) NARP1 PF12569.8 EGD95365.1 - 1.5 7.7 19.2 1 8.2 18.1 1.3 1 1 0 1 1 1 0 NMDA receptor-regulated protein 1 U79_P34 PF03064.16 EGD95365.1 - 2.7 7.3 14.1 2.7 7.3 14.1 1.2 1 0 0 1 1 1 0 HSV U79 / HCMV P34 DUF4407 PF14362.6 EGD95365.1 - 4.1 6.7 13.5 4.6 6.5 13.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF4778 PF16008.5 EGD95365.1 - 4.7 7.2 11.3 5.2 7.0 11.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4778) V_ATPase_I PF01496.19 EGD95365.1 - 8.8 4.1 7.8 8.6 4.1 7.8 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family GTP_EFTU PF00009.27 EGD95366.1 - 3.6e-09 36.4 0.0 8.2e-09 35.3 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EGD95366.1 - 0.0016 18.4 0.3 0.4 10.6 0.1 2.4 2 0 0 2 2 2 2 RsgA GTPase AAA_18 PF13238.6 EGD95366.1 - 0.008 16.7 0.0 0.019 15.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.27 EGD95366.1 - 0.0094 16.5 0.0 0.03 14.8 0.1 1.8 2 0 0 2 2 2 1 ABC transporter AAA_16 PF13191.6 EGD95366.1 - 0.016 15.6 0.2 0.063 13.7 0.2 2.1 1 1 0 1 1 1 0 AAA ATPase domain AAA_29 PF13555.6 EGD95366.1 - 0.026 14.3 0.2 0.066 13.0 0.2 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain FtsK_SpoIIIE PF01580.18 EGD95366.1 - 0.044 13.1 0.1 0.086 12.2 0.1 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family MMR_HSR1 PF01926.23 EGD95366.1 - 0.065 13.3 0.1 0.37 10.9 0.1 2.1 1 1 0 1 1 1 0 50S ribosome-binding GTPase ATP_bind_1 PF03029.17 EGD95366.1 - 0.15 11.8 0.1 7.1 6.3 0.0 2.2 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein Pkr1 PF08636.10 EGD95367.1 - 2e-30 104.7 4.5 2.7e-30 104.3 4.5 1.2 1 0 0 1 1 1 1 ER protein Pkr1 Phage_Gp23 PF10669.9 EGD95367.1 - 0.11 12.8 3.8 1.2 9.4 3.8 2.1 1 1 0 1 1 1 0 Protein gp23 (Bacteriophage A118) ANAPC2 PF08672.11 EGD95368.1 - 2e-22 79.5 0.3 5.6e-22 78.0 0.3 1.9 1 0 0 1 1 1 1 Anaphase promoting complex (APC) subunit 2 Cullin PF00888.22 EGD95368.1 - 3.1e-22 79.0 0.2 5.6e-22 78.1 0.2 1.3 1 0 0 1 1 1 1 Cullin family DUF3235 PF11574.8 EGD95368.1 - 0.14 13.0 6.1 0.32 11.9 6.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3235) SNF2_N PF00176.23 EGD95369.1 - 9.4e-28 96.9 0.0 1.5e-26 93.0 0.0 2.6 2 1 0 2 2 2 1 SNF2 family N-terminal domain ResIII PF04851.15 EGD95369.1 - 1.6e-06 28.2 0.0 4.1e-06 26.9 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit APH PF01636.23 EGD95371.1 - 0.00053 20.0 0.1 0.0011 18.9 0.1 1.5 1 1 0 1 1 1 1 Phosphotransferase enzyme family Presenilin PF01080.17 EGD95371.1 - 1.1 8.0 2.6 1.5 7.5 2.6 1.1 1 0 0 1 1 1 0 Presenilin F-box-like PF12937.7 EGD95372.1 - 2.2e-08 33.8 0.9 6.4e-08 32.4 0.6 2.0 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 EGD95372.1 - 6.7e-07 29.0 0.5 1.8e-06 27.7 0.5 1.7 1 0 0 1 1 1 1 F-box domain TPR_2 PF07719.17 EGD95372.1 - 0.1 12.7 0.6 6.6 7.1 0.2 2.5 1 1 1 2 2 2 0 Tetratricopeptide repeat Mito_carr PF00153.27 EGD95373.1 - 7.8e-60 198.8 1.7 2.7e-21 75.3 0.2 4.1 3 1 0 3 3 3 3 Mitochondrial carrier protein SpoIIP PF07454.11 EGD95374.1 - 0.088 12.2 5.7 0.15 11.5 5.7 1.3 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) DUF4407 PF14362.6 EGD95374.1 - 0.36 10.1 8.3 0.67 9.3 8.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) eIF-3_zeta PF05091.12 EGD95374.1 - 0.46 9.4 16.3 0.021 13.8 10.1 1.7 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) KAR9 PF08580.10 EGD95375.1 - 9.7e-246 817.6 0.1 9.7e-246 817.6 0.1 2.6 2 1 0 2 2 2 1 Yeast cortical protein KAR9 CDC45 PF02724.14 EGD95376.1 - 1.1 7.5 5.9 1.5 7.1 5.9 1.1 1 0 0 1 1 1 0 CDC45-like protein CRAL_TRIO PF00650.20 EGD95377.1 - 1.1e-28 99.9 0.0 1.7e-28 99.3 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 EGD95377.1 - 5.8e-07 29.6 0.1 1.9e-06 27.9 0.1 1.9 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.6 EGD95377.1 - 0.0022 18.1 0.0 0.0044 17.2 0.0 1.4 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain DUF1769 PF08588.10 EGD95377.1 - 0.081 13.1 0.0 0.18 12.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1769) Acylphosphatase PF00708.18 EGD95379.1 - 1.8e-17 63.5 0.1 2.1e-17 63.3 0.1 1.0 1 0 0 1 1 1 1 Acylphosphatase AOX PF01786.17 EGD95380.1 - 9.6e-99 329.3 0.0 1.2e-98 329.0 0.0 1.1 1 0 0 1 1 1 1 Alternative oxidase adh_short_C2 PF13561.6 EGD95381.1 - 1.3e-50 172.2 0.0 1.7e-50 171.7 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EGD95381.1 - 6.4e-45 153.0 0.0 8.5e-45 152.6 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EGD95381.1 - 1.1e-06 28.7 0.0 1.6e-06 28.2 0.0 1.2 1 0 0 1 1 1 1 KR domain THF_DHG_CYH_C PF02882.19 EGD95381.1 - 0.013 14.8 0.0 0.022 14.1 0.0 1.3 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain DUF1776 PF08643.10 EGD95381.1 - 0.022 14.1 0.1 0.033 13.5 0.1 1.2 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) PALP PF00291.25 EGD95381.1 - 0.063 12.7 0.0 0.086 12.2 0.0 1.2 1 0 0 1 1 1 0 Pyridoxal-phosphate dependent enzyme Epimerase PF01370.21 EGD95381.1 - 0.14 11.6 0.0 0.21 11.0 0.0 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family TMEMspv1-c74-12 PF11044.8 EGD95382.1 - 0.099 12.6 3.3 0.18 11.8 3.3 1.4 1 0 0 1 1 1 0 Plectrovirus spv1-c74 ORF 12 transmembrane protein MBOAT PF03062.19 EGD95384.1 - 1.3e-44 153.0 14.4 1.5e-33 116.6 6.7 2.3 2 0 0 2 2 2 2 MBOAT, membrane-bound O-acyltransferase family FA_desaturase PF00487.24 EGD95385.1 - 8e-29 101.2 22.8 1.2e-28 100.6 22.8 1.3 1 0 0 1 1 1 1 Fatty acid desaturase Cyt-b5 PF00173.28 EGD95385.1 - 3.6e-07 30.2 0.0 6.9e-07 29.3 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Laps PF10169.9 EGD95385.1 - 0.47 11.0 4.5 0.8 10.3 4.5 1.3 1 0 0 1 1 1 0 Learning-associated protein zf-HIT PF04438.16 EGD95388.1 - 3.6e-10 39.5 7.2 5.3e-10 39.0 7.2 1.3 1 0 0 1 1 1 1 HIT zinc finger Dopey_N PF04118.14 EGD95389.1 - 1.5e-119 398.7 0.0 1.2e-118 395.8 0.0 2.4 3 0 0 3 3 3 1 Dopey, N-terminal Mon1 PF03164.14 EGD95390.1 - 1.3e-149 498.7 0.0 1.5e-149 498.5 0.0 1.0 1 0 0 1 1 1 1 Trafficking protein Mon1 DEAD PF00270.29 EGD95391.1 - 5.8e-22 78.3 0.0 1.3e-21 77.1 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EGD95391.1 - 4.1e-21 75.4 0.7 3e-17 62.9 0.0 3.1 3 0 0 3 3 3 2 Helicase conserved C-terminal domain RQC PF09382.10 EGD95391.1 - 5.3e-15 55.2 0.0 1.2e-14 54.0 0.0 1.7 1 0 0 1 1 1 1 RQC domain RecQ_Zn_bind PF16124.5 EGD95391.1 - 1.2e-13 51.5 8.7 1.2e-13 51.5 8.7 2.3 2 0 0 2 2 2 1 RecQ zinc-binding HRDC PF00570.23 EGD95391.1 - 1.2e-07 31.6 0.0 2.8e-07 30.4 0.0 1.6 1 0 0 1 1 1 1 HRDC domain ResIII PF04851.15 EGD95391.1 - 3.5e-06 27.1 0.0 1e-05 25.6 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit MutS_V PF00488.21 EGD95393.1 - 2e-73 246.5 0.1 3.9e-73 245.5 0.1 1.5 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 EGD95393.1 - 4.5e-34 118.3 0.6 1.2e-33 117.0 0.6 1.7 1 0 0 1 1 1 1 MutS domain III MutS_I PF01624.20 EGD95393.1 - 7e-29 100.4 0.1 1.5e-28 99.3 0.1 1.6 1 0 0 1 1 1 1 MutS domain I MutS_II PF05188.17 EGD95393.1 - 5.2e-10 39.7 0.0 2.7e-09 37.4 0.0 2.3 2 0 0 2 2 2 1 MutS domain II MutS_IV PF05190.18 EGD95393.1 - 9.8e-06 25.8 0.2 2.5e-05 24.5 0.2 1.8 1 0 0 1 1 1 1 MutS family domain IV LpxB PF02684.15 EGD95393.1 - 0.046 12.5 0.0 0.086 11.7 0.0 1.3 1 0 0 1 1 1 0 Lipid-A-disaccharide synthetase DUF2052 PF09747.9 EGD95393.1 - 2 8.5 7.4 5 7.2 7.4 1.7 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Ribosomal_S28e PF01200.18 EGD95394.1 - 4.4e-33 113.1 0.4 4.9e-33 112.9 0.4 1.0 1 0 0 1 1 1 1 Ribosomal protein S28e HisG PF01634.18 EGD95395.1 - 1.7e-54 184.1 0.0 2.4e-54 183.6 0.0 1.2 1 0 0 1 1 1 1 ATP phosphoribosyltransferase HisG_C PF08029.11 EGD95395.1 - 1.6e-28 98.6 0.3 3.6e-28 97.5 0.3 1.6 1 0 0 1 1 1 1 HisG, C-terminal domain NMT1 PF09084.11 EGD95395.1 - 0.0026 17.7 0.0 0.0075 16.2 0.0 1.7 1 1 0 1 1 1 1 NMT1/THI5 like AAA PF00004.29 EGD95396.1 - 1.5e-54 183.9 0.0 2.9e-43 147.5 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) PEX-1N PF09262.11 EGD95396.1 - 2.1e-30 104.9 0.6 4.8e-30 103.8 0.6 1.7 1 0 0 1 1 1 1 Peroxisome biogenesis factor 1, N-terminal AAA_lid_3 PF17862.1 EGD95396.1 - 8e-15 54.4 0.1 3e-08 33.3 0.0 2.7 2 0 0 2 2 2 2 AAA+ lid domain AAA_16 PF13191.6 EGD95396.1 - 1.8e-08 34.9 3.2 0.0049 17.3 0.1 4.3 2 2 1 3 3 3 2 AAA ATPase domain AAA_2 PF07724.14 EGD95396.1 - 9e-07 29.2 0.0 0.053 13.6 0.0 2.7 3 0 0 3 3 2 2 AAA domain (Cdc48 subfamily) NACHT PF05729.12 EGD95396.1 - 1e-06 28.8 0.4 0.00067 19.6 0.0 3.4 3 0 0 3 3 3 1 NACHT domain RuvB_N PF05496.12 EGD95396.1 - 1.6e-05 24.7 0.0 0.022 14.5 0.0 2.8 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain TsaE PF02367.17 EGD95396.1 - 6.4e-05 23.0 0.1 0.12 12.3 0.0 2.8 3 0 0 3 3 3 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE IstB_IS21 PF01695.17 EGD95396.1 - 9.9e-05 22.1 0.0 0.071 12.8 0.0 2.4 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_22 PF13401.6 EGD95396.1 - 0.00014 22.2 1.0 1.4 9.2 0.1 3.7 2 2 1 3 3 3 2 AAA domain AAA_5 PF07728.14 EGD95396.1 - 0.00068 19.7 0.0 1.9 8.5 0.0 2.9 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_14 PF13173.6 EGD95396.1 - 0.00077 19.5 0.0 0.81 9.7 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.6 EGD95396.1 - 0.0019 18.7 0.0 2.1 8.9 0.0 2.7 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.12 EGD95396.1 - 0.0032 16.8 0.0 0.72 9.1 0.0 2.3 2 0 0 2 2 2 1 Zeta toxin TIP49 PF06068.13 EGD95396.1 - 0.0033 16.7 0.0 2 7.5 0.0 2.3 2 0 0 2 2 2 2 TIP49 P-loop domain AAA_33 PF13671.6 EGD95396.1 - 0.0034 17.5 0.0 0.17 12.0 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.6 EGD95396.1 - 0.0036 16.9 0.3 5.8 6.4 0.2 3.1 2 1 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 EGD95396.1 - 0.0097 16.3 0.0 7.4 7.0 0.0 2.7 2 0 0 2 2 2 0 RNA helicase AAA_28 PF13521.6 EGD95396.1 - 0.016 15.4 0.0 3 8.1 0.0 2.5 2 0 0 2 2 2 0 AAA domain Mg_chelatase PF01078.21 EGD95396.1 - 0.02 14.3 0.5 1 8.7 0.1 2.7 3 0 0 3 3 2 0 Magnesium chelatase, subunit ChlI T2SSE PF00437.20 EGD95396.1 - 0.028 13.5 0.0 0.07 12.2 0.0 1.6 2 0 0 2 2 2 0 Type II/IV secretion system protein ABC_tran PF00005.27 EGD95396.1 - 0.03 14.8 0.0 5.7 7.5 0.1 2.7 2 0 0 2 2 2 0 ABC transporter KAP_NTPase PF07693.14 EGD95396.1 - 0.05 12.8 0.1 0.39 9.9 0.0 2.1 1 1 1 2 2 2 0 KAP family P-loop domain AAA_7 PF12775.7 EGD95396.1 - 0.067 12.7 0.0 1.6 8.2 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region Viral_helicase1 PF01443.18 EGD95396.1 - 0.069 12.9 0.2 0.34 10.6 0.0 2.3 3 0 0 3 3 2 0 Viral (Superfamily 1) RNA helicase ATPase PF06745.13 EGD95396.1 - 0.087 12.2 0.1 15 4.9 0.0 2.5 2 0 0 2 2 2 0 KaiC APS_kinase PF01583.20 EGD95396.1 - 0.15 11.9 0.1 0.63 9.9 0.0 2.1 2 0 0 2 2 2 0 Adenylylsulphate kinase Sigma54_activat PF00158.26 EGD95396.1 - 0.19 11.4 0.0 7.8 6.2 0.0 2.7 3 0 0 3 3 3 0 Sigma-54 interaction domain AAA_17 PF13207.6 EGD95396.1 - 0.31 11.4 2.3 2.7 8.4 0.0 3.2 4 0 0 4 4 3 0 AAA domain DUF1840 PF08895.11 EGD95396.1 - 0.36 11.2 1.0 1.7 9.0 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1840) MCM PF00493.23 EGD95397.1 - 6.6e-103 342.6 0.0 1.1e-102 342.0 0.0 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 EGD95397.1 - 2e-31 108.5 0.1 3.5e-31 107.7 0.1 1.3 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 EGD95397.1 - 1e-21 77.1 0.7 2.8e-21 75.7 0.7 1.8 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 EGD95397.1 - 5.7e-18 65.4 0.2 1.7e-17 63.9 0.2 1.9 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 EGD95397.1 - 3.2e-07 29.9 0.0 4.8e-05 22.8 0.0 2.5 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 EGD95397.1 - 2.2e-05 24.5 0.0 5.6e-05 23.2 0.0 1.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) Mg_chelatase_C PF13335.6 EGD95397.1 - 0.031 14.9 0.1 0.13 12.9 0.1 2.1 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI C-terminal AAA_lid_2 PF17863.1 EGD95397.1 - 0.047 13.5 0.0 0.13 12.1 0.0 1.7 1 0 0 1 1 1 0 AAA lid domain AAA_3 PF07726.11 EGD95397.1 - 0.06 13.2 0.0 0.17 11.7 0.0 1.8 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA-ATPase_like PF09820.9 EGD95397.1 - 0.11 11.9 0.3 0.27 10.6 0.3 1.6 1 1 0 1 1 1 0 Predicted AAA-ATPase EGF_CA PF07645.15 EGD95399.1 - 6.7e-06 26.2 5.1 6.7e-06 26.2 5.1 1.7 2 0 0 2 2 2 1 Calcium-binding EGF domain FXa_inhibition PF14670.6 EGD95399.1 - 0.003 17.8 3.4 0.003 17.8 3.4 2.5 2 1 0 2 2 2 1 Coagulation Factor Xa inhibitory site EGF_3 PF12947.7 EGD95399.1 - 0.0034 17.5 5.0 0.0034 17.5 5.0 2.1 2 1 0 2 2 2 1 EGF domain cEGF PF12662.7 EGD95399.1 - 0.004 17.0 0.1 0.004 17.0 0.1 2.2 2 0 0 2 2 2 1 Complement Clr-like EGF-like Plasmod_Pvs28 PF06247.11 EGD95399.1 - 0.0068 16.7 1.7 0.0068 16.7 1.7 1.9 2 0 0 2 2 2 1 Pvs28 EGF domain EGF PF00008.27 EGD95399.1 - 0.0079 16.5 5.2 0.0079 16.5 5.2 2.0 2 1 0 2 2 2 1 EGF-like domain hEGF PF12661.7 EGD95399.1 - 6.1 7.6 10.0 0.83 10.4 0.8 2.7 2 0 0 2 2 2 0 Human growth factor-like EGF MFS_1 PF07690.16 EGD95401.1 - 2.2e-39 135.4 31.6 2.4e-33 115.5 24.8 2.0 2 0 0 2 2 2 2 Major Facilitator Superfamily MFS_4 PF06779.14 EGD95401.1 - 9.7e-07 28.4 13.7 2.5e-05 23.7 3.6 2.3 2 0 0 2 2 2 2 Uncharacterised MFS-type transporter YbfB OATP PF03137.20 EGD95401.1 - 4.6e-05 21.9 13.0 0.00016 20.2 8.3 3.2 2 1 0 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1_like PF12832.7 EGD95401.1 - 0.0026 16.7 14.9 0.07 12.0 10.2 2.2 2 0 0 2 2 2 2 MFS_1 like family Mucin15 PF15672.5 EGD95401.1 - 0.19 11.2 3.0 4.4 6.7 0.1 2.3 2 0 0 2 2 2 0 Cell-membrane associated Mucin15 Paired_CXXCH_1 PF09699.10 EGD95403.1 - 0.025 14.3 0.7 0.051 13.3 0.7 1.5 1 0 0 1 1 1 0 Doubled CXXCH motif (Paired_CXXCH_1) SNF2_N PF00176.23 EGD95404.1 - 0.0029 16.4 0.0 0.0032 16.2 0.0 1.1 1 0 0 1 1 1 1 SNF2 family N-terminal domain AMP-binding PF00501.28 EGD95406.1 - 3.3e-92 309.3 0.0 4e-92 309.0 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EGD95406.1 - 2.7e-16 60.3 0.1 1.3e-15 58.1 0.0 2.2 2 1 0 2 2 2 1 AMP-binding enzyme C-terminal domain CMAS PF02353.20 EGD95408.1 - 2.8e-56 190.8 0.0 3.8e-56 190.4 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_23 PF13489.6 EGD95408.1 - 1.1e-08 35.0 0.0 2e-08 34.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EGD95408.1 - 2.6e-08 34.5 0.0 5.8e-08 33.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EGD95408.1 - 3e-08 34.2 0.0 1.1e-07 32.4 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EGD95408.1 - 0.002 18.9 0.0 0.0045 17.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain DOT1 PF08123.13 EGD95408.1 - 0.012 15.2 0.0 0.02 14.5 0.0 1.3 1 0 0 1 1 1 0 Histone methylation protein DOT1 FtsJ PF01728.19 EGD95408.1 - 0.11 12.6 0.0 0.18 11.9 0.0 1.3 1 0 0 1 1 1 0 FtsJ-like methyltransferase MTS PF05175.14 EGD95408.1 - 0.12 11.9 0.1 0.21 11.1 0.1 1.3 1 0 0 1 1 1 0 Methyltransferase small domain PCMT PF01135.19 EGD95408.1 - 0.18 11.5 0.0 0.27 10.9 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Dicty_REP PF05086.12 EGD95409.1 - 0.42 8.5 6.1 0.57 8.1 6.1 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Tropomyosin_1 PF12718.7 EGD95410.1 - 6.3e-50 169.1 34.7 7.8e-50 168.8 34.7 1.1 1 0 0 1 1 1 1 Tropomyosin like Tropomyosin PF00261.20 EGD95410.1 - 8.6e-10 38.4 35.5 4e-06 26.4 16.2 2.1 1 1 1 2 2 2 2 Tropomyosin KLRAQ PF10205.9 EGD95410.1 - 0.00014 22.0 24.6 0.0003 21.0 10.3 3.3 1 1 1 3 3 3 2 Predicted coiled-coil domain-containing protein Spc7 PF08317.11 EGD95410.1 - 0.00022 20.2 34.1 0.091 11.6 18.1 2.0 1 1 1 2 2 2 2 Spc7 kinetochore protein GAS PF13851.6 EGD95410.1 - 0.0011 18.4 33.5 0.0086 15.5 26.6 2.2 1 1 1 2 2 2 1 Growth-arrest specific micro-tubule binding DUF1664 PF07889.12 EGD95410.1 - 0.0018 18.3 18.7 0.0073 16.3 4.0 2.5 1 1 1 2 2 2 2 Protein of unknown function (DUF1664) CENP-F_leu_zip PF10473.9 EGD95410.1 - 0.0023 18.0 6.2 0.0023 18.0 6.2 3.1 1 1 2 3 3 3 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ATG16 PF08614.11 EGD95410.1 - 0.01 16.1 32.7 0.34 11.1 24.2 2.2 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) DHR10 PF18595.1 EGD95410.1 - 0.011 15.8 16.7 0.011 15.8 16.7 2.7 1 1 1 2 2 2 0 Designed helical repeat protein 10 domain Laminin_II PF06009.12 EGD95410.1 - 0.012 15.6 8.4 0.012 15.6 8.4 2.1 1 1 1 2 2 2 0 Laminin Domain II Med9 PF07544.13 EGD95410.1 - 0.013 15.5 6.1 0.013 15.5 6.1 3.2 1 1 1 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 ADIP PF11559.8 EGD95410.1 - 0.025 14.7 33.2 0.42 10.7 10.5 3.0 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding MAD PF05557.13 EGD95410.1 - 0.025 13.0 31.8 0.035 12.5 31.8 1.1 1 0 0 1 1 1 0 Mitotic checkpoint protein CEP63 PF17045.5 EGD95410.1 - 0.16 11.8 29.3 1.1 9.0 29.3 1.9 1 1 0 1 1 1 0 Centrosomal protein of 63 kDa DUF4200 PF13863.6 EGD95410.1 - 0.18 12.2 35.0 0.21 12.0 15.3 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) ERM PF00769.19 EGD95410.1 - 0.22 11.3 39.9 0.18 11.6 19.7 2.0 1 1 1 2 2 2 0 Ezrin/radixin/moesin family DUF724 PF05266.14 EGD95410.1 - 0.27 11.0 28.9 0.12 12.2 10.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF724) SesA PF17107.5 EGD95410.1 - 0.38 10.9 10.2 0.17 12.1 6.8 2.1 1 1 0 1 1 1 0 N-terminal domain on NACHT_NTPase and P-loop NTPases BLOC1_2 PF10046.9 EGD95410.1 - 0.41 11.0 24.2 1.3 9.4 1.0 3.4 1 1 3 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 FlaC_arch PF05377.11 EGD95410.1 - 0.41 11.1 22.3 0.62 10.5 0.3 4.3 2 1 1 4 4 4 0 Flagella accessory protein C (FlaC) Jnk-SapK_ap_N PF09744.9 EGD95410.1 - 0.55 10.4 35.3 0.079 13.2 23.7 2.2 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 Laminin_I PF06008.14 EGD95410.1 - 0.58 9.8 27.2 93 2.6 27.2 2.7 1 1 0 1 1 1 0 Laminin Domain I SlyX PF04102.12 EGD95410.1 - 0.75 10.5 26.9 1.8 9.2 1.7 3.5 1 1 2 3 3 3 0 SlyX CLZ PF16526.5 EGD95410.1 - 0.85 10.0 24.8 0.31 11.4 2.8 3.3 1 1 1 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Atg14 PF10186.9 EGD95410.1 - 1.1 8.2 27.9 3.7 6.5 11.9 2.1 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 AAA_13 PF13166.6 EGD95410.1 - 1.3 7.6 27.7 4.8 5.7 27.7 2.0 1 1 0 1 1 1 0 AAA domain DUF3584 PF12128.8 EGD95410.1 - 1.3 6.5 29.6 1.8 6.0 29.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DUF3450 PF11932.8 EGD95410.1 - 1.6 8.0 31.1 0.44 9.8 12.5 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) BST2 PF16716.5 EGD95410.1 - 2.2 8.9 29.4 2.1 9.0 11.5 3.3 1 1 3 4 4 4 0 Bone marrow stromal antigen 2 Cep57_MT_bd PF06657.13 EGD95410.1 - 2.3 8.7 23.5 0.054 13.9 3.8 3.7 2 1 2 4 4 4 0 Centrosome microtubule-binding domain of Cep57 Fez1 PF06818.15 EGD95410.1 - 2.7 8.4 30.2 3.2 8.2 26.9 1.9 1 1 1 2 2 2 0 Fez1 JIP_LZII PF16471.5 EGD95410.1 - 2.8 8.2 27.3 0.29 11.4 5.4 4.0 2 1 1 4 4 4 0 JNK-interacting protein leucine zipper II KxDL PF10241.9 EGD95410.1 - 3 8.2 22.5 0.39 11.0 1.2 4.0 1 1 3 4 4 4 0 Uncharacterized conserved protein KELK PF15796.5 EGD95410.1 - 3.2 8.3 33.8 16 6.0 15.2 3.6 1 1 2 3 3 3 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase DUF16 PF01519.16 EGD95410.1 - 3.4 8.2 24.1 17 6.0 5.2 2.7 1 1 1 2 2 2 0 Protein of unknown function DUF16 FUSC PF04632.12 EGD95410.1 - 3.7 6.0 9.1 4.2 5.8 9.1 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family DUF948 PF06103.11 EGD95410.1 - 3.8 7.8 12.9 10 6.5 4.5 3.0 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) UPF0242 PF06785.11 EGD95410.1 - 4.3 7.4 33.4 13 5.8 13.3 2.1 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus PI3K_P85_iSH2 PF16454.5 EGD95410.1 - 4.6 6.8 29.3 9.1 5.9 23.3 2.5 1 1 1 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain PspB PF06667.12 EGD95410.1 - 5 7.3 18.7 0.73 9.9 4.7 3.7 1 1 2 3 3 3 0 Phage shock protein B Fmp27_SW PF10305.9 EGD95410.1 - 5.2 7.8 7.9 0.52 11.1 1.3 2.3 1 1 2 3 3 3 0 RNA pol II promoter Fmp27 protein domain MS_channel PF00924.18 EGD95410.1 - 6 6.3 5.0 9.7 5.7 5.0 1.6 1 1 0 1 1 1 0 Mechanosensitive ion channel TMF_DNA_bd PF12329.8 EGD95410.1 - 6.3 6.9 37.5 0.67 10.0 14.4 3.3 2 1 1 3 3 3 0 TATA element modulatory factor 1 DNA binding XhlA PF10779.9 EGD95410.1 - 6.8 7.0 27.0 6.2 7.1 1.7 4.2 1 1 3 4 4 4 0 Haemolysin XhlA YabA PF06156.13 EGD95410.1 - 7.3 7.3 26.5 1.8e+04 -6.3 26.2 3.1 1 1 0 1 1 0 0 Initiation control protein YabA TMF_TATA_bd PF12325.8 EGD95410.1 - 7.4 6.8 33.6 36 4.6 15.0 2.9 1 1 2 3 3 3 0 TATA element modulatory factor 1 TATA binding APG6_N PF17675.1 EGD95410.1 - 7.8 7.0 40.5 18 5.8 16.8 2.6 1 1 1 2 2 2 0 Apg6 coiled-coil region bZIP_1 PF00170.21 EGD95410.1 - 8 6.7 27.2 2.4 8.3 0.7 4.4 2 1 2 4 4 4 0 bZIP transcription factor Nop25 PF09805.9 EGD95411.1 - 2e-38 132.0 8.4 2e-38 132.0 8.4 3.1 2 1 1 3 3 3 1 Nucleolar protein 12 (25kDa) EIIBC-GUT_N PF03612.14 EGD95411.1 - 0.15 11.8 10.3 0.14 11.9 1.0 2.5 2 1 1 3 3 3 0 Sorbitol phosphotransferase enzyme II N-terminus CDC45 PF02724.14 EGD95411.1 - 1.8 6.7 30.7 0.12 10.6 18.8 2.0 2 0 0 2 2 2 0 CDC45-like protein YL1 PF05764.13 EGD95411.1 - 1.8 8.6 38.9 0.28 11.3 21.7 2.3 2 0 0 2 2 2 0 YL1 nuclear protein ATP-synt_S1 PF05827.12 EGD95412.1 - 5.2e-05 23.1 0.0 0.0001 22.2 0.0 1.4 1 0 0 1 1 1 1 Vacuolar ATP synthase subunit S1 (ATP6S1) DUF2615 PF11027.8 EGD95413.1 - 9.1 6.5 9.6 6 7.1 0.0 3.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2615) Sin_N PF04801.13 EGD95414.1 - 1.7e-27 96.7 0.5 6.7e-27 94.8 0.5 1.7 1 1 0 1 1 1 1 Sin-like protein conserved region RNA_pol PF00940.19 EGD95415.1 - 9.7e-184 611.0 0.0 1.4e-183 610.4 0.0 1.3 1 0 0 1 1 1 1 DNA-dependent RNA polymerase RPOL_N PF14700.6 EGD95415.1 - 3.6e-92 309.3 0.5 5.3e-92 308.8 0.5 1.3 1 0 0 1 1 1 1 DNA-directed RNA polymerase N-terminal HGTP_anticodon2 PF12745.7 EGD95417.1 - 0.015 14.8 1.4 0.017 14.6 1.4 1.0 1 0 0 1 1 1 0 Anticodon binding domain of tRNAs T2SSI PF02501.17 EGD95418.1 - 0.35 11.1 3.5 0.6 10.3 3.5 1.4 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein I Radical_SAM PF04055.21 EGD95419.1 - 8.2e-09 36.0 0.0 1.2e-08 35.5 0.0 1.3 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_12 PF13353.6 EGD95419.1 - 9.1e-05 22.7 0.0 0.00016 21.9 0.0 1.4 1 0 0 1 1 1 1 4Fe-4S single cluster domain Fer4_14 PF13394.6 EGD95419.1 - 0.032 14.4 0.0 0.11 12.7 0.0 1.9 2 0 0 2 2 2 0 4Fe-4S single cluster domain Fructosamin_kin PF03881.14 EGD95420.1 - 9.8e-30 103.7 0.0 1.2e-29 103.4 0.0 1.0 1 0 0 1 1 1 1 Fructosamine kinase APH PF01636.23 EGD95420.1 - 0.092 12.6 0.0 0.11 12.4 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family WD40 PF00400.32 EGD95421.1 - 4.2e-06 27.4 0.9 0.36 11.8 0.0 5.8 6 0 0 6 6 6 1 WD domain, G-beta repeat DUF676 PF05057.14 EGD95421.1 - 1.9e-05 24.3 0.0 9.1e-05 22.1 0.0 2.0 2 0 0 2 2 2 1 Putative serine esterase (DUF676) PGAP1 PF07819.13 EGD95421.1 - 0.0032 17.2 0.0 0.011 15.5 0.0 1.9 1 1 0 1 1 1 1 PGAP1-like protein Abhydrolase_6 PF12697.7 EGD95421.1 - 0.0087 16.7 0.0 0.022 15.4 0.0 1.7 1 0 0 1 1 1 1 Alpha/beta hydrolase family MFS_1 PF07690.16 EGD95422.1 - 1.4e-11 43.9 25.4 2.2e-07 30.1 2.2 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily NADH-u_ox-rdase PF10785.9 EGD95422.1 - 0.052 14.2 0.6 1.7 9.4 0.2 2.9 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase complex I, 21 kDa subunit DUF92 PF01940.16 EGD95423.1 - 8.1e-83 277.5 4.6 9.7e-83 277.2 4.6 1.1 1 0 0 1 1 1 1 Integral membrane protein DUF92 TPR_2 PF07719.17 EGD95425.1 - 3.8e-05 23.5 0.0 0.011 15.7 0.0 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat DUF1635 PF07795.11 EGD95425.1 - 0.026 14.4 0.1 0.77 9.6 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1635) TPR_1 PF00515.28 EGD95425.1 - 0.077 12.8 0.0 3.6 7.6 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 EGD95425.1 - 0.083 13.7 0.0 9.7 7.3 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.6 EGD95425.1 - 0.17 11.6 0.0 6.3 6.6 0.0 2.5 2 0 0 2 2 2 0 TPR repeat Methyltransf_33 PF10017.9 EGD95426.1 - 1.3e-86 290.5 0.0 1.9e-86 290.0 0.0 1.1 1 0 0 1 1 1 1 Histidine-specific methyltransferase, SAM-dependent FGE-sulfatase PF03781.16 EGD95426.1 - 1.7e-19 70.4 4.9 2e-18 66.9 4.9 2.1 1 1 0 1 1 1 1 Sulfatase-modifying factor enzyme 1 DinB_2 PF12867.7 EGD95426.1 - 1.1e-06 29.2 1.7 5.5e-06 26.9 1.0 2.3 2 0 0 2 2 2 1 DinB superfamily GAD-like PF08887.11 EGD95426.1 - 0.012 15.4 0.0 0.031 14.1 0.0 1.7 1 0 0 1 1 1 0 GAD-like domain DUF2890 PF11081.8 EGD95426.1 - 0.21 11.7 0.9 0.45 10.6 0.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2890) LRRC37 PF15779.5 EGD95427.1 - 0.19 12.1 0.0 0.35 11.2 0.0 1.4 1 0 0 1 1 1 0 Leucine-rich repeat-containing protein 37 family Aldedh PF00171.22 EGD95428.1 - 7.2e-131 436.9 0.0 8.1e-131 436.7 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.14 EGD95428.1 - 0.00018 20.7 0.0 0.00087 18.4 0.0 1.9 2 0 0 2 2 2 1 Acyl-CoA reductase (LuxC) CdiI_2 PF18593.1 EGD95428.1 - 0.17 12.6 0.1 0.71 10.6 0.0 2.0 2 0 0 2 2 2 0 CdiI immunity protein Lipase_GDSL_2 PF13472.6 EGD95430.1 - 1.7e-12 48.1 0.2 4.3e-11 43.5 0.2 2.1 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 EGD95430.1 - 3.2e-05 24.0 0.0 5.5e-05 23.2 0.0 1.4 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase TFIIA_gamma_N PF02268.16 EGD95431.1 - 1.7e-24 85.5 0.1 2.4e-24 85.1 0.1 1.2 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit, helical domain TFIIA_gamma_C PF02751.14 EGD95431.1 - 9.4e-24 83.3 1.0 9.4e-24 83.3 1.0 1.6 2 0 0 2 2 2 1 Transcription initiation factor IIA, gamma subunit Hexokinase_1 PF00349.21 EGD95434.1 - 1.4e-61 207.8 0.0 2.2e-61 207.3 0.0 1.3 1 0 0 1 1 1 1 Hexokinase Hexokinase_2 PF03727.16 EGD95434.1 - 4.7e-39 134.2 0.0 4.3e-38 131.1 0.0 2.2 1 1 0 1 1 1 1 Hexokinase SR-25 PF10500.9 EGD95434.1 - 0.13 11.8 4.4 0.21 11.2 4.4 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein GILT PF03227.16 EGD95435.1 - 5.1e-15 55.6 1.7 4.9e-14 52.5 1.0 2.6 1 1 0 1 1 1 1 Gamma interferon inducible lysosomal thiol reductase (GILT) Carla_C4 PF01623.17 EGD95436.1 - 9.4 6.3 8.1 0.27 11.2 1.4 1.9 1 1 1 2 2 2 0 Carlavirus putative nucleic acid binding protein MFS_1 PF07690.16 EGD95437.1 - 6.3e-32 110.9 24.9 6.3e-32 110.9 24.9 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily GCP_N_terminal PF17681.1 EGD95438.1 - 8.1e-30 104.5 0.0 3.2e-29 102.5 0.0 1.8 2 0 0 2 2 2 1 Gamma tubulin complex component N-terminal GCP_C_terminal PF04130.13 EGD95438.1 - 1.8e-25 90.1 0.0 2.8e-25 89.4 0.0 1.3 1 0 0 1 1 1 1 Gamma tubulin complex component C-terminal DUF3459 PF11941.8 EGD95438.1 - 0.052 13.9 0.1 0.16 12.3 0.1 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF3459) ThiF PF00899.21 EGD95439.1 - 2.3e-113 377.5 0.0 3.7e-75 252.4 0.0 2.3 2 1 0 2 2 2 2 ThiF family UBA_e1_thiolCys PF10585.9 EGD95439.1 - 9.1e-96 320.6 1.3 5.4e-95 318.1 0.6 2.0 2 0 0 2 2 2 1 Ubiquitin-activating enzyme active site E1_FCCH PF16190.5 EGD95439.1 - 5e-30 103.5 0.1 1.1e-29 102.5 0.1 1.6 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 FCCH domain E1_UFD PF09358.10 EGD95439.1 - 2.9e-28 98.4 0.0 6.7e-28 97.2 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin fold domain E1_4HB PF16191.5 EGD95439.1 - 2.5e-20 72.5 1.6 2.5e-20 72.5 1.6 2.1 2 0 0 2 2 2 1 Ubiquitin-activating enzyme E1 four-helix bundle GST_N_2 PF13409.6 EGD95440.1 - 1.1e-22 80.1 0.0 2.7e-22 78.8 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EGD95440.1 - 1.6e-13 50.4 0.0 3.3e-13 49.4 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EGD95440.1 - 6.8e-06 26.4 0.1 0.00044 20.6 0.1 2.6 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EGD95440.1 - 4.1e-05 23.7 0.0 0.00013 22.1 0.0 2.0 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Mito_carr PF00153.27 EGD95441.1 - 9.4e-67 221.0 5.3 6.9e-23 80.4 0.1 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein EF-hand_7 PF13499.6 EGD95441.1 - 3.5e-22 78.6 5.6 1.4e-11 44.7 0.5 2.5 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 EGD95441.1 - 6e-19 66.1 7.3 4.1e-05 22.8 1.1 4.4 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 EGD95441.1 - 4e-17 60.6 11.0 9.9e-06 25.1 0.1 4.4 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 EGD95441.1 - 1.7e-16 58.9 11.3 1.4e-05 24.3 1.2 4.4 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.6 EGD95441.1 - 3.1e-12 46.1 3.6 6e-06 26.0 0.2 4.1 2 2 2 4 4 4 4 EF-hand domain pair SPARC_Ca_bdg PF10591.9 EGD95441.1 - 2e-09 37.8 0.3 0.0004 20.7 0.1 2.3 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 EGD95441.1 - 0.00099 19.0 4.1 0.29 11.1 0.5 3.2 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand EF-hand_10 PF14788.6 EGD95441.1 - 0.0059 16.5 0.2 3.2 7.7 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_9 PF14658.6 EGD95441.1 - 0.022 15.1 0.0 6.6 7.1 0.0 3.1 3 0 0 3 3 3 0 EF-hand domain Cyclin_N PF00134.23 EGD95442.1 - 4.1e-11 42.7 0.1 6.2e-11 42.1 0.1 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C_2 PF16899.5 EGD95442.1 - 0.035 14.5 0.1 0.13 12.7 0.0 1.9 2 0 0 2 2 2 0 Cyclin C-terminal domain DUF4452 PF14618.6 EGD95443.1 - 6.8e-52 175.7 7.0 6.8e-52 175.7 7.0 2.6 1 1 1 2 2 2 1 Domain of unknown function (DUF4452) Zip PF02535.22 EGD95443.1 - 0.046 12.9 2.9 0.051 12.8 2.9 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter MAP65_ASE1 PF03999.12 EGD95443.1 - 0.98 8.0 4.6 0.95 8.1 4.6 1.1 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) Rubella_E2 PF05749.11 EGD95443.1 - 2 7.8 10.1 0.059 12.8 3.6 1.6 2 0 0 2 2 2 0 Rubella membrane glycoprotein E2 FAM76 PF16046.5 EGD95443.1 - 2.2 7.6 7.0 3 7.1 7.0 1.2 1 0 0 1 1 1 0 FAM76 protein F-box-like PF12937.7 EGD95445.1 - 0.0032 17.3 0.9 0.0064 16.4 0.3 1.9 2 0 0 2 2 2 1 F-box-like Chal_sti_synt_C PF02797.15 EGD95446.1 - 3.1e-18 66.2 0.0 5.7e-18 65.3 0.0 1.5 1 0 0 1 1 1 1 Chalcone and stilbene synthases, C-terminal domain Chal_sti_synt_N PF00195.19 EGD95446.1 - 2.8e-14 53.1 0.1 4.4e-14 52.4 0.1 1.2 1 0 0 1 1 1 1 Chalcone and stilbene synthases, N-terminal domain ACP_syn_III_C PF08541.10 EGD95446.1 - 0.0019 18.3 0.0 0.015 15.5 0.0 2.1 2 0 0 2 2 2 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal AMP-binding PF00501.28 EGD95448.1 - 4e-185 615.4 0.0 8.2e-65 219.0 0.0 4.2 3 1 1 4 4 4 4 AMP-binding enzyme Condensation PF00668.20 EGD95448.1 - 1.3e-58 198.8 0.0 4.3e-28 98.2 0.0 4.6 3 2 0 3 3 3 3 Condensation domain PP-binding PF00550.25 EGD95448.1 - 8.5e-38 128.5 5.2 1.3e-12 47.8 0.0 4.7 4 0 0 4 4 4 3 Phosphopantetheine attachment site AMP-binding_C PF13193.6 EGD95448.1 - 1.4e-07 32.4 0.0 0.22 12.5 0.0 3.7 3 0 0 3 3 3 2 AMP-binding enzyme C-terminal domain MFS_1 PF07690.16 EGD95449.1 - 1.9e-14 53.4 33.9 2.9e-08 33.0 8.1 3.9 1 1 2 3 3 3 3 Major Facilitator Superfamily PRIMA1 PF16101.5 EGD95449.1 - 0.083 12.9 0.3 0.083 12.9 0.3 2.2 3 0 0 3 3 3 0 Proline-rich membrane anchor 1 SNARE PF05739.19 EGD95450.1 - 6.2e-10 38.9 0.1 1.2e-09 38.0 0.1 1.5 1 0 0 1 1 1 1 SNARE domain DUF1676 PF07898.13 EGD95450.1 - 0.019 15.0 0.0 0.036 14.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1676) Spectrin PF00435.21 EGD95450.1 - 0.099 13.1 1.7 0.24 11.9 0.1 2.1 2 0 0 2 2 2 0 Spectrin repeat TPR_MLP1_2 PF07926.12 EGD95450.1 - 0.28 11.2 3.9 0.14 12.2 1.2 1.8 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein zf-TRAF PF02176.18 EGD95451.1 - 8.8e-08 32.7 40.9 1.1e-05 26.0 8.0 4.7 2 1 3 5 5 4 4 TRAF-type zinc finger zf-TRAF_2 PF15965.5 EGD95451.1 - 2.1e-07 31.3 10.2 2.1e-07 31.3 10.2 3.2 1 1 1 3 3 2 1 TRAF-like zinc-finger zf-RING_2 PF13639.6 EGD95451.1 - 0.00039 20.7 15.3 0.00039 20.7 15.3 4.3 2 1 3 5 5 5 1 Ring finger domain zf-RING_5 PF14634.6 EGD95451.1 - 0.0016 18.3 14.0 0.0016 18.3 14.0 3.3 2 1 0 2 2 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EGD95451.1 - 0.0034 17.4 13.2 0.0034 17.4 13.2 2.5 3 0 0 3 3 2 1 RING-type zinc-finger zf-C3HC4 PF00097.25 EGD95451.1 - 0.012 15.4 15.1 0.012 15.4 15.1 4.0 4 0 0 4 4 4 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EGD95451.1 - 0.023 14.9 14.9 0.023 14.9 14.9 3.2 4 0 0 4 4 4 0 zinc finger of C3HC4-type, RING TSC22 PF01166.18 EGD95451.1 - 0.092 13.1 0.9 5.3 7.4 0.2 2.6 2 0 0 2 2 2 0 TSC-22/dip/bun family DUF2730 PF10805.8 EGD95451.1 - 0.35 11.0 1.2 4.9 7.3 0.4 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2730) zf_UBZ PF18439.1 EGD95451.1 - 4.6 6.9 13.5 4.7 6.9 2.5 3.9 4 0 0 4 4 4 0 Ubiquitin-Binding Zinc Finger Sina PF03145.16 EGD95451.1 - 5.1 7.0 21.8 9 6.2 6.7 2.7 1 1 1 2 2 2 0 Seven in absentia protein family zf-RING_6 PF14835.6 EGD95451.1 - 7.2 6.6 14.7 20 5.1 12.3 3.0 1 1 1 2 2 2 0 zf-RING of BARD1-type protein Het-C PF07217.11 EGD95453.1 - 6.3e-278 922.9 0.0 7.6e-278 922.7 0.0 1.0 1 0 0 1 1 1 1 Heterokaryon incompatibility protein Het-C Metal_resist PF13801.6 EGD95454.1 - 0.0088 16.2 0.9 0.013 15.7 0.1 1.6 2 0 0 2 2 2 1 Heavy-metal resistance DUF2336 PF10098.9 EGD95455.1 - 0.021 14.3 0.6 0.021 14.3 0.6 2.3 2 1 0 2 2 2 0 Uncharacterised protein conserved in bacteria (DUF2336) Med4 PF10018.9 EGD95455.1 - 0.055 13.1 4.7 0.13 12.0 4.7 1.6 1 0 0 1 1 1 0 Vitamin-D-receptor interacting Mediator subunit 4 UPF0242 PF06785.11 EGD95455.1 - 0.42 10.7 6.3 0.26 11.4 4.6 1.5 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Ank_2 PF12796.7 EGD95456.1 - 1.7e-40 137.5 0.1 4.6e-10 39.9 0.0 8.4 8 0 0 8 8 8 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EGD95456.1 - 4.1e-37 126.1 3.2 1.4e-05 25.5 0.0 10.9 9 2 2 11 11 11 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EGD95456.1 - 7e-30 99.8 7.3 0.0014 18.9 0.1 12.2 12 0 0 12 12 12 7 Ankyrin repeat Ank_5 PF13857.6 EGD95456.1 - 1.2e-26 92.5 9.3 1.7e-05 25.0 0.0 10.6 11 0 0 11 11 11 6 Ankyrin repeats (many copies) Ank PF00023.30 EGD95456.1 - 2.2e-25 87.9 3.4 0.00073 19.9 0.1 8.9 8 1 0 8 8 8 6 Ankyrin repeat Polbeta PF18765.1 EGD95456.1 - 0.12 12.4 0.1 0.47 10.6 0.1 2.1 1 0 0 1 1 1 0 Polymerase beta, Nucleotidyltransferase IBN_N PF03810.19 EGD95457.1 - 1.3e-10 41.0 0.7 1.1e-08 34.9 0.1 3.2 3 0 0 3 3 3 1 Importin-beta N-terminal domain Xpo1 PF08389.12 EGD95457.1 - 2.5e-05 24.4 0.1 0.00088 19.4 0.1 3.2 2 1 0 2 2 2 1 Exportin 1-like protein Proteasom_PSMB PF10508.9 EGD95457.1 - 8.3e-05 21.3 1.7 0.0027 16.3 0.0 3.0 3 0 0 3 3 3 1 Proteasome non-ATPase 26S subunit RIX1 PF08167.12 EGD95457.1 - 0.00067 19.5 3.1 0.013 15.2 0.0 3.9 4 0 0 4 4 4 1 rRNA processing/ribosome biogenesis CAS_CSE1 PF03378.15 EGD95457.1 - 0.00095 17.8 0.2 0.0049 15.4 0.0 2.2 3 0 0 3 3 3 1 CAS/CSE protein, C-terminus HORMA PF02301.18 EGD95459.1 - 3.6e-10 39.8 0.0 4.2e-10 39.6 0.0 1.1 1 0 0 1 1 1 1 HORMA domain IBR PF01485.21 EGD95460.1 - 2.1e-07 31.0 7.1 2.1e-07 31.0 7.1 3.7 3 1 0 3 3 3 2 IBR domain, a half RING-finger domain Pkinase PF00069.25 EGD95461.1 - 5.2e-12 45.7 0.0 5.1e-07 29.3 0.0 2.1 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EGD95461.1 - 0.0047 16.2 0.1 0.033 13.5 0.0 2.2 3 0 0 3 3 3 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EGD95461.1 - 0.018 13.9 0.0 0.025 13.3 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase Kdo PF06293.14 EGD95461.1 - 0.1 11.9 0.0 0.18 11.2 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pectate_lyase22 PF14583.6 EGD95461.1 - 0.17 10.5 0.0 0.23 10.1 0.0 1.1 1 0 0 1 1 1 0 Oligogalacturonate lyase Acetyltransf_7 PF13508.7 EGD95463.1 - 0.00035 20.9 0.0 0.00065 20.1 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EGD95463.1 - 0.0044 17.1 0.0 0.012 15.7 0.0 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 EGD95463.1 - 0.054 13.6 0.0 0.12 12.5 0.0 1.6 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase FR47 PF08445.10 EGD95463.1 - 0.084 12.9 0.0 0.2 11.7 0.0 1.6 1 0 0 1 1 1 0 FR47-like protein Dcc1 PF09724.9 EGD95464.1 - 1.7e-29 103.2 2.3 2.1e-26 93.0 0.0 2.0 2 0 0 2 2 2 2 Sister chromatid cohesion protein Dcc1 PrmC_N PF17827.1 EGD95464.1 - 0.2 12.3 0.9 1.7 9.3 0.3 2.4 2 0 0 2 2 2 0 PrmC N-terminal domain Anp1 PF03452.14 EGD95465.1 - 2.4e-111 371.4 0.0 2.4e-111 371.4 0.0 2.4 2 1 0 3 3 3 1 Anp1 Smg8_Smg9 PF10220.9 EGD95465.1 - 1.1 7.5 17.6 1.8 6.8 17.6 1.3 1 0 0 1 1 1 0 Smg8_Smg9 tRNA_bind PF01588.20 EGD95466.1 - 5.8e-20 71.2 0.0 2.9e-19 69.0 0.0 2.1 1 1 0 1 1 1 1 Putative tRNA binding domain GST_C_2 PF13410.6 EGD95466.1 - 0.029 14.4 0.0 0.053 13.6 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Asp PF00026.23 EGD95467.1 - 5.5e-60 203.4 0.0 6.4e-60 203.2 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EGD95467.1 - 6.9e-09 36.2 0.3 0.0041 17.4 0.0 2.5 1 1 1 2 2 2 2 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 EGD95467.1 - 1.3e-06 29.0 0.8 0.0067 17.0 0.2 2.7 2 1 0 2 2 2 2 Aspartyl protease gag-asp_proteas PF13975.6 EGD95467.1 - 5.7e-05 23.6 0.2 0.029 14.9 0.1 2.9 2 1 0 2 2 2 2 gag-polyprotein putative aspartyl protease ParA PF10609.9 EGD95468.1 - 2.5e-95 318.6 0.0 3e-95 318.4 0.0 1.0 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 EGD95468.1 - 5.2e-08 33.0 0.0 1.7e-07 31.3 0.0 1.8 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 EGD95468.1 - 5.4e-06 26.4 0.0 1.8e-05 24.7 0.0 1.8 1 1 0 1 1 1 1 AAA domain ArsA_ATPase PF02374.15 EGD95468.1 - 1e-05 24.9 1.2 0.00023 20.5 0.3 2.5 1 1 0 2 2 2 1 Anion-transporting ATPase MipZ PF09140.11 EGD95468.1 - 0.0041 16.5 0.0 0.0089 15.3 0.0 1.5 1 1 0 1 1 1 1 ATPase MipZ AAA_26 PF13500.6 EGD95468.1 - 0.0049 16.7 0.0 1.3 8.9 0.0 2.1 2 0 0 2 2 2 2 AAA domain CLP1_P PF16575.5 EGD95468.1 - 0.012 15.4 0.0 0.02 14.7 0.0 1.3 1 0 0 1 1 1 0 mRNA cleavage and polyadenylation factor CLP1 P-loop RsgA_GTPase PF03193.16 EGD95468.1 - 0.02 14.8 0.0 0.039 13.9 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase AAA_25 PF13481.6 EGD95468.1 - 0.025 14.2 0.0 0.044 13.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 EGD95468.1 - 0.051 13.3 0.0 0.082 12.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain SRP54 PF00448.22 EGD95468.1 - 0.11 12.1 0.0 0.25 11.0 0.0 1.7 1 1 0 1 1 1 0 SRP54-type protein, GTPase domain TsaE PF02367.17 EGD95468.1 - 0.14 12.2 0.0 0.27 11.2 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE RNA_helicase PF00910.22 EGD95468.1 - 0.15 12.5 0.0 0.26 11.7 0.0 1.4 1 0 0 1 1 1 0 RNA helicase PEMT PF04191.13 EGD95469.1 - 2.4e-60 201.5 9.3 1.7e-36 124.8 0.7 3.3 3 0 0 3 3 3 2 Phospholipid methyltransferase SKICH PF17751.1 EGD95469.1 - 0.035 14.6 0.1 1.4 9.6 0.0 2.4 2 0 0 2 2 2 0 SKICH domain HECW_N PF16562.5 EGD95469.1 - 0.038 13.8 0.1 0.13 12.1 0.1 1.8 2 0 0 2 2 2 0 N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2 RNase_PH PF01138.21 EGD95470.1 - 3.1e-26 92.4 0.1 6e-26 91.5 0.0 1.5 2 0 0 2 2 2 1 3' exoribonuclease family, domain 1 Lactamase_B PF00753.27 EGD95471.1 - 7.8e-10 39.1 0.0 1.7e-09 38.0 0.0 1.6 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EGD95471.1 - 0.00074 19.1 0.0 0.0013 18.3 0.0 1.4 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Bim_N PF06773.11 EGD95472.1 - 0.067 12.9 0.2 1 9.1 0.0 2.3 2 0 0 2 2 2 0 Bim protein N-terminus GST_N_3 PF13417.6 EGD95473.1 - 0.085 13.3 0.4 0.26 11.7 0.1 2.0 2 0 0 2 2 2 0 Glutathione S-transferase, N-terminal domain MFS_1 PF07690.16 EGD95474.1 - 2.1e-33 115.7 38.4 1.5e-24 86.6 12.4 2.6 2 1 1 3 3 3 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EGD95474.1 - 3e-08 33.0 9.1 3e-08 33.0 9.1 2.6 3 0 0 3 3 3 1 Sugar (and other) transporter MFS_3 PF05977.13 EGD95474.1 - 0.067 11.6 1.1 0.11 10.9 1.1 1.3 1 0 0 1 1 1 0 Transmembrane secretion effector ProRS-C_1 PF09180.11 EGD95475.1 - 3.5e-23 81.6 3.7 7.4e-23 80.5 3.4 1.7 2 0 0 2 2 2 1 Prolyl-tRNA synthetase, C-terminal tRNA-synt_2b PF00587.25 EGD95475.1 - 1e-17 64.7 0.0 1.8e-17 63.9 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 EGD95475.1 - 4.5e-12 46.0 0.0 1.2e-11 44.6 0.0 1.8 2 0 0 2 2 2 1 Anticodon binding domain Cpn60_TCP1 PF00118.24 EGD95476.1 - 4.3e-150 500.6 16.5 4.9e-150 500.4 16.5 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family WD40 PF00400.32 EGD95477.1 - 4e-13 49.6 9.3 0.00039 21.2 0.1 5.7 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EGD95477.1 - 1.9e-06 28.1 0.0 0.0092 16.3 0.0 4.3 3 2 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain S1 PF00575.23 EGD95478.1 - 6.4e-70 231.5 40.0 1.6e-15 57.2 0.5 12.4 12 0 0 12 12 12 10 S1 RNA binding domain TPR_19 PF14559.6 EGD95478.1 - 2.9e-05 24.5 0.0 0.01 16.3 0.1 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat RNase_II_C_S1 PF18614.1 EGD95478.1 - 8.2e-05 22.5 0.0 1 9.3 0.0 5.0 5 0 0 5 5 5 1 RNase II-type exonuclease C-terminal S1 domain TPR_14 PF13428.6 EGD95478.1 - 0.00017 22.1 0.1 0.54 11.2 0.1 4.5 2 1 2 4 4 4 1 Tetratricopeptide repeat Suf PF05843.14 EGD95478.1 - 0.0009 19.3 12.4 0.028 14.4 0.0 4.4 2 2 1 4 4 3 2 Suppressor of forked protein (Suf) PCB_OB PF17092.5 EGD95478.1 - 0.0028 18.4 12.7 3 8.6 0.0 6.6 6 0 0 6 6 6 2 Penicillin-binding protein OB-like domain TPR_16 PF13432.6 EGD95478.1 - 0.0089 16.7 0.0 14 6.4 0.0 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat NRDE-2 PF08424.10 EGD95478.1 - 0.014 14.5 0.0 0.077 12.1 0.0 2.1 2 0 0 2 2 2 0 NRDE-2, necessary for RNA interference PPR PF01535.20 EGD95478.1 - 0.098 12.9 0.0 32 5.1 0.0 3.3 2 1 1 3 3 3 0 PPR repeat Cue1_U7BR PF18499.1 EGD95478.1 - 0.12 12.4 1.4 0.17 11.9 0.0 2.0 2 0 0 2 2 1 0 Ubc7p-binding region of Cue1 S1_2 PF13509.6 EGD95478.1 - 0.63 10.2 5.5 26 4.9 0.0 5.6 7 0 0 7 7 7 0 S1 domain PP28 PF10252.9 EGD95479.1 - 0.031 14.7 0.2 0.032 14.7 0.2 1.1 1 0 0 1 1 1 0 Casein kinase substrate phosphoprotein PP28 DDHD PF02862.17 EGD95480.1 - 0.091 12.9 5.1 0.1 12.8 5.1 1.2 1 0 0 1 1 1 0 DDHD domain Presenilin PF01080.17 EGD95480.1 - 0.85 8.3 7.6 0.87 8.3 7.6 1.1 1 0 0 1 1 1 0 Presenilin V_ATPase_I PF01496.19 EGD95480.1 - 1.5 6.7 3.1 1.6 6.6 3.1 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Phage_lysozyme PF00959.19 EGD95481.1 - 1.5e-11 44.7 0.0 1.8e-11 44.5 0.0 1.1 1 0 0 1 1 1 1 Phage lysozyme UreD PF01774.17 EGD95482.1 - 6.1e-78 261.6 0.0 7.3e-78 261.3 0.0 1.1 1 0 0 1 1 1 1 UreD urease accessory protein STAG PF08514.11 EGD95483.1 - 9.2e-40 135.1 1.4 9.2e-40 135.1 1.4 3.7 3 0 0 3 3 3 1 STAG domain YL1 PF05764.13 EGD95483.1 - 0.004 17.3 21.7 0.004 17.3 21.7 4.5 4 1 1 5 5 5 1 YL1 nuclear protein HEAT_2 PF13646.6 EGD95483.1 - 0.005 17.2 0.0 0.24 11.8 0.3 3.1 1 1 1 2 2 2 1 HEAT repeats FAM209 PF15206.6 EGD95483.1 - 0.11 12.2 0.1 0.11 12.2 0.1 2.7 2 0 0 2 2 2 0 FAM209 family Allexi_40kDa PF05549.11 EGD95483.1 - 6.8 6.1 11.9 0.3 10.6 0.1 3.7 2 2 1 3 3 3 0 Allexivirus 40kDa protein GFA PF04828.14 EGD95484.1 - 1.5e-14 54.1 2.8 2.2e-14 53.5 2.8 1.3 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme Acatn PF13000.7 EGD95485.1 - 3.6e-155 517.6 15.4 1.8e-82 277.6 8.5 3.2 1 1 2 3 3 3 3 Acetyl-coenzyme A transporter 1 CENP-O PF09496.10 EGD95486.1 - 9.6e-66 221.8 0.0 1.3e-64 218.1 0.0 2.0 2 0 0 2 2 2 1 Cenp-O kinetochore centromere component CENP-H PF05837.12 EGD95488.1 - 0.065 13.7 0.7 0.065 13.7 0.7 2.9 3 0 0 3 3 3 0 Centromere protein H (CENP-H) MreB_Mbl PF06723.13 EGD95488.1 - 0.23 10.2 0.2 0.33 9.7 0.2 1.1 1 0 0 1 1 1 0 MreB/Mbl protein Atg29_N PF18388.1 EGD95489.1 - 2.9e-21 75.0 0.4 5.7e-21 74.1 0.4 1.5 1 0 0 1 1 1 1 Atg29 N-terminal domain DFP PF04127.15 EGD95491.1 - 1.4e-12 47.8 0.0 6.7e-05 22.8 0.0 3.2 2 1 1 3 3 3 3 DNA / pantothenate metabolism flavoprotein Polysacc_deac_1 PF01522.21 EGD95492.1 - 6e-19 68.2 0.0 1e-18 67.4 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide deacetylase Glyco_hydro_57 PF03065.15 EGD95492.1 - 0.0029 16.8 0.0 0.0066 15.7 0.0 1.6 1 0 0 1 1 1 1 Glycosyl hydrolase family 57 DUF2334 PF10096.9 EGD95492.1 - 0.11 12.1 0.0 0.18 11.4 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2334) DEAD PF00270.29 EGD95493.1 - 3.5e-42 144.1 0.0 6.1e-42 143.4 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EGD95493.1 - 2.1e-27 95.6 0.0 5.9e-26 91.0 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain UTP25 PF06862.12 EGD95493.1 - 0.019 13.8 0.0 2.4 6.8 0.0 2.4 2 0 0 2 2 2 0 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 ResIII PF04851.15 EGD95493.1 - 0.025 14.6 0.0 0.054 13.5 0.0 1.6 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit Glyoxal_oxid_N PF07250.11 EGD95494.1 - 1.8e-37 128.9 0.0 9.1e-37 126.5 0.0 2.2 3 0 0 3 3 3 1 Glyoxal oxidase N-terminus DUF1929 PF09118.11 EGD95494.1 - 1.6e-24 86.0 0.2 3.4e-24 85.0 0.2 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1929) Chitin_bind_1 PF00187.19 EGD95494.1 - 4.9e-06 26.9 20.5 4.9e-06 26.9 20.5 2.4 2 0 0 2 2 2 1 Chitin recognition protein Kelch_6 PF13964.6 EGD95494.1 - 0.00093 19.4 0.4 23 5.5 0.0 5.6 6 0 0 6 6 6 1 Kelch motif PQQ_2 PF13360.6 EGD95494.1 - 0.085 12.4 0.0 1.4 8.4 0.0 2.3 2 0 0 2 2 2 0 PQQ-like domain Fumble PF03630.14 EGD95495.1 - 1.3e-144 481.5 0.9 1.6e-144 481.1 0.9 1.1 1 0 0 1 1 1 1 Fumble GPI2 PF06432.11 EGD95496.1 - 3.2e-129 430.3 6.4 3.9e-129 430.0 6.4 1.1 1 0 0 1 1 1 1 Phosphatidylinositol N-acetylglucosaminyltransferase Intg_mem_TP0381 PF09529.10 EGD95496.1 - 3.7 7.0 8.8 3.1 7.2 0.4 2.7 3 0 0 3 3 3 0 Integral membrane protein (intg_mem_TP0381) Macoilin PF09726.9 EGD95497.1 - 0.025 13.2 9.7 0.03 12.9 9.7 1.0 1 0 0 1 1 1 0 Macoilin family PTPRCAP PF15713.5 EGD95497.1 - 0.54 10.5 12.9 0.051 13.9 6.7 2.0 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated EMC3_TMCO1 PF01956.16 EGD95497.1 - 1.1 9.0 2.2 1.6 8.4 2.2 1.2 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like AIF_C PF14721.6 EGD95497.1 - 3.7 7.9 9.3 51 4.2 7.8 2.2 2 0 0 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Glyco_hydro_18 PF00704.28 EGD95501.1 - 2.6e-22 80.0 0.1 1.1e-21 77.9 0.1 1.9 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 SLATT_5 PF18160.1 EGD95503.1 - 0.41 9.9 2.5 0.54 9.6 0.5 2.2 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain family 5 Bunya_G2 PF03563.13 EGD95503.1 - 1.8 7.7 6.2 3.3 6.9 6.2 1.4 1 0 0 1 1 1 0 Bunyavirus glycoprotein G2 AA_permease_2 PF13520.6 EGD95504.1 - 1.3e-46 159.3 55.2 1.6e-46 159.0 55.2 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EGD95504.1 - 4.7e-23 81.5 47.5 5.9e-23 81.2 47.5 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EGD95506.1 - 1.1e-48 166.1 46.5 1.5e-48 165.7 46.5 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EGD95506.1 - 5e-29 101.2 41.4 6.6e-29 100.8 41.4 1.0 1 0 0 1 1 1 1 Amino acid permease Dynamin_N PF00350.23 EGD95507.1 - 1.1e-27 97.2 0.0 2.4e-27 96.0 0.0 1.7 1 0 0 1 1 1 1 Dynamin family Dynamin_M PF01031.20 EGD95507.1 - 1.9e-26 93.0 0.5 3.1e-25 88.9 0.1 2.7 2 1 0 2 2 2 1 Dynamin central region MMR_HSR1 PF01926.23 EGD95507.1 - 0.0036 17.4 0.0 0.021 14.9 0.0 2.2 1 1 0 1 1 1 1 50S ribosome-binding GTPase OSCP PF00213.18 EGD95507.1 - 0.083 13.0 0.0 8.9 6.4 0.0 2.6 2 0 0 2 2 2 0 ATP synthase delta (OSCP) subunit GED PF02212.18 EGD95507.1 - 4.6 7.5 10.6 0.77 10.0 0.7 4.0 5 0 0 5 5 5 0 Dynamin GTPase effector domain DUF2254 PF10011.9 EGD95508.1 - 0.047 12.5 0.8 0.068 12.0 0.8 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2254) HemY_N PF07219.13 EGD95508.1 - 0.15 12.3 1.3 0.3 11.3 1.3 1.5 1 0 0 1 1 1 0 HemY protein N-terminus Col_cuticle_N PF01484.17 EGD95508.1 - 0.82 9.8 6.2 2 8.6 6.2 1.7 1 0 0 1 1 1 0 Nematode cuticle collagen N-terminal domain 5_nucleotid_C PF02872.18 EGD95510.1 - 4.7e-33 114.6 0.1 2e-31 109.4 0.1 2.3 1 1 0 1 1 1 1 5'-nucleotidase, C-terminal domain Metallophos PF00149.28 EGD95510.1 - 0.00026 21.6 1.0 0.00058 20.4 1.0 1.6 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase TMEM154 PF15102.6 EGD95511.1 - 0.0012 18.7 0.0 0.0013 18.7 0.0 1.1 1 0 0 1 1 1 1 TMEM154 protein family Protocadherin PF08374.11 EGD95511.1 - 0.028 14.4 0.0 0.032 14.2 0.0 1.1 1 0 0 1 1 1 0 Protocadherin DUF5385 PF17359.2 EGD95511.1 - 0.054 13.0 0.0 0.071 12.7 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5385) DUF5367 PF17329.2 EGD95511.1 - 0.1 12.7 0.1 0.15 12.2 0.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5367) Chordopox_A13L PF05961.11 EGD95511.1 - 0.11 12.8 0.1 0.18 12.1 0.1 1.3 1 0 0 1 1 1 0 Chordopoxvirus A13L protein Aldedh PF00171.22 EGD95512.1 - 5.1e-153 509.9 0.1 6.4e-153 509.6 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Glyco_trans_2_3 PF13632.6 EGD95514.1 - 0.033 14.1 0.0 0.046 13.6 0.0 1.2 1 0 0 1 1 1 0 Glycosyl transferase family group 2 Gln-synt_C PF00120.24 EGD95518.1 - 6.9e-63 212.7 0.0 2.2e-62 211.1 0.0 1.7 1 1 0 1 1 1 1 Glutamine synthetase, catalytic domain Amidohydro_2 PF04909.14 EGD95518.1 - 5.9e-14 52.5 0.0 1.1e-13 51.6 0.0 1.4 1 0 0 1 1 1 1 Amidohydrolase Gln-synt_N_2 PF16952.5 EGD95518.1 - 0.075 12.9 0.0 0.15 11.9 0.0 1.5 1 0 0 1 1 1 0 Glutamine synthetase N-terminal domain MFS_1 PF07690.16 EGD95519.1 - 2.4e-36 125.4 22.8 2.4e-36 125.4 22.8 2.0 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EGD95519.1 - 4.4e-14 52.2 9.8 4.4e-14 52.2 9.8 2.7 2 1 0 3 3 3 1 Sugar (and other) transporter TRI12 PF06609.13 EGD95519.1 - 0.00029 19.4 3.3 0.00048 18.7 3.3 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFA1_2 PF17317.2 EGD95519.1 - 0.18 11.6 0.7 0.45 10.3 0.0 2.1 2 0 0 2 2 2 0 Mating hormone A-factor 1&2 UPF0016 PF01169.19 EGD95522.1 - 4.9e-39 132.5 26.3 1.7e-19 69.9 7.5 2.3 2 0 0 2 2 2 2 Uncharacterized protein family UPF0016 Mntp PF02659.15 EGD95522.1 - 0.02 14.6 0.1 0.02 14.6 0.1 2.2 2 0 0 2 2 2 0 Putative manganese efflux pump DUF2070 PF09843.9 EGD95522.1 - 0.025 12.9 2.1 0.04 12.2 2.1 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) DUF4614 PF15391.6 EGD95522.1 - 1.1 9.3 0.0 1.1 9.3 0.0 2.9 3 1 2 5 5 5 0 Domain of unknown function (DUF4614) DUF3357 PF11837.8 EGD95522.1 - 9 6.8 9.3 45 4.6 0.1 4.1 4 1 0 4 4 4 0 Domain of unknown function (DUF3357) Myb_DNA-binding PF00249.31 EGD95524.1 - 0.00014 22.0 0.3 0.00031 20.9 0.3 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain TRF PF08558.10 EGD95524.1 - 0.0012 18.5 0.0 0.0021 17.7 0.0 1.4 1 0 0 1 1 1 1 Telomere repeat binding factor (TRF) Annexin PF00191.20 EGD95525.1 - 2.2e-13 50.1 5.9 0.0024 17.9 0.1 4.6 4 1 0 4 4 4 4 Annexin Ribosomal_L21e PF01157.18 EGD95526.1 - 8.7e-31 105.8 4.1 8.7e-31 105.8 4.1 1.6 2 0 0 2 2 2 1 Ribosomal protein L21e DUF5486 PF17588.2 EGD95526.1 - 0.23 11.4 3.0 0.93 9.4 0.8 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5486) Strep_his_triad PF04270.13 EGD95526.1 - 0.54 10.3 1.8 4.6 7.3 0.2 2.7 1 1 1 2 2 2 0 Streptococcal histidine triad protein S4 PF01479.25 EGD95527.1 - 3.7e-12 45.8 1.3 3.7e-12 45.8 1.3 2.3 3 0 0 3 3 3 1 S4 domain Ribosomal_S4 PF00163.19 EGD95527.1 - 1.9e-06 28.7 0.2 4e-06 27.6 0.2 1.6 1 0 0 1 1 1 1 Ribosomal protein S4/S9 N-terminal domain Vault_2 PF17794.1 EGD95529.1 - 0.24 11.8 0.3 0.48 10.8 0.3 1.4 1 0 0 1 1 1 0 Major Vault Protein repeat domain Amidoligase_2 PF12224.8 EGD95530.1 - 4.3e-08 33.1 0.0 0.003 17.3 0.0 3.0 2 1 0 2 2 2 2 Putative amidoligase enzyme Vps62 PF06101.11 EGD95532.1 - 1.1e-10 40.5 0.8 1.5e-08 33.5 0.3 2.1 2 0 0 2 2 2 2 Vacuolar protein sorting-associated protein 62 Septin PF00735.18 EGD95533.1 - 1.5e-34 119.6 0.0 1.4e-13 50.8 0.0 3.2 2 1 0 3 3 3 3 Septin FtsK_SpoIIIE PF01580.18 EGD95533.1 - 0.056 12.8 0.0 0.12 11.7 0.0 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_23 PF13476.6 EGD95533.1 - 0.13 12.7 0.8 0.48 10.9 0.3 2.2 2 1 0 2 2 2 0 AAA domain Dynamin_N PF00350.23 EGD95533.1 - 0.21 11.6 1.3 0.74 9.9 0.0 2.5 3 0 0 3 3 3 0 Dynamin family DUF3275 PF11679.8 EGD95533.1 - 0.24 11.4 4.0 0.67 9.9 4.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3275) DUF348 PF03990.14 EGD95533.1 - 0.4 10.5 2.3 3.7 7.4 0.4 2.5 2 0 0 2 2 2 0 G5-linked-Ubiquitin-like domain Mito_carr PF00153.27 EGD95534.1 - 4.7e-74 244.4 1.3 1.1e-24 86.2 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein HMD PF03201.16 EGD95534.1 - 0.12 12.6 0.0 4.8 7.5 0.0 3.0 3 0 0 3 3 3 0 H2-forming N5,N10-methylene-tetrahydromethanopterin dehydrogenase SecE PF00584.20 EGD95537.1 - 9.7e-14 51.0 0.0 1.2e-13 50.8 0.0 1.1 1 0 0 1 1 1 1 SecE/Sec61-gamma subunits of protein translocation complex RRM_1 PF00076.22 EGD95538.1 - 3.5e-06 26.8 0.0 6.1e-06 26.0 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FYDLN_acid PF09538.10 EGD95538.1 - 0.0083 16.8 4.8 0.018 15.7 4.8 1.5 1 0 0 1 1 1 1 Protein of unknown function (FYDLN_acid) PA26 PF04636.13 EGD95538.1 - 0.13 11.1 4.4 0.18 10.7 4.4 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Presenilin PF01080.17 EGD95538.1 - 0.74 8.5 11.0 0.93 8.2 11.0 1.2 1 0 0 1 1 1 0 Presenilin Ndc1_Nup PF09531.10 EGD95538.1 - 1 8.0 7.5 1.2 7.8 7.5 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Menin PF05053.13 EGD95538.1 - 3.3 5.9 13.8 5.2 5.3 13.8 1.2 1 0 0 1 1 1 0 Menin DUF4407 PF14362.6 EGD95538.1 - 3.7 6.8 6.4 4.3 6.6 6.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Suf PF05843.14 EGD95538.1 - 4.8 7.1 16.1 8.5 6.3 16.1 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) GREB1 PF15782.5 EGD95538.1 - 4.8 4.2 9.2 6.2 3.8 9.2 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Hid1 PF12722.7 EGD95538.1 - 6.1 4.8 11.3 7.3 4.6 11.3 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein TERB2 PF15101.6 EGD95538.1 - 6.8 6.7 14.4 8.5 6.4 14.0 1.4 1 1 0 1 1 1 0 Telomere-associated protein TERB2 Connexin PF00029.19 EGD95538.1 - 9.7 5.9 5.8 16 5.1 5.8 1.3 1 0 0 1 1 1 0 Connexin WD40 PF00400.32 EGD95539.1 - 5.5e-19 68.2 17.2 0.0011 19.8 0.2 8.0 8 0 0 8 8 8 6 WD domain, G-beta repeat Cytochrom_D1 PF02239.16 EGD95539.1 - 2.8e-06 26.1 0.6 0.018 13.6 0.0 3.9 4 0 0 4 4 4 2 Cytochrome D1 heme domain ANAPC4_WD40 PF12894.7 EGD95539.1 - 1.7e-05 25.0 0.0 0.35 11.2 0.0 4.3 4 1 0 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain PQQ_3 PF13570.6 EGD95539.1 - 0.00062 20.2 3.7 0.19 12.3 0.1 4.5 4 0 0 4 4 4 1 PQQ-like domain PD40 PF07676.12 EGD95539.1 - 0.17 11.9 3.5 0.3 11.1 0.0 3.2 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat DNA_pol_phi PF04931.13 EGD95539.1 - 0.94 7.5 20.2 1.2 7.1 20.2 1.1 1 0 0 1 1 1 0 DNA polymerase phi Nop14 PF04147.12 EGD95539.1 - 4.3 5.4 11.5 5.8 5.0 11.5 1.1 1 0 0 1 1 1 0 Nop14-like family SDA1 PF05285.12 EGD95539.1 - 6 6.2 11.5 8.8 5.6 11.5 1.1 1 0 0 1 1 1 0 SDA1 PX PF00787.24 EGD95540.1 - 3.1e-27 94.8 0.2 3.7e-27 94.6 0.2 1.1 1 0 0 1 1 1 1 PX domain Myb_DNA-bind_6 PF13921.6 EGD95541.1 - 1.1e-15 57.6 0.2 2.4e-07 30.9 0.0 3.0 3 0 0 3 3 3 2 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 EGD95541.1 - 3.5e-12 46.3 0.1 3.9e-06 27.0 0.0 2.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain SLIDE PF09111.10 EGD95541.1 - 0.011 15.8 0.0 7.5 6.6 0.0 2.5 2 0 0 2 2 2 0 SLIDE RasGEF PF00617.19 EGD95543.1 - 5.7e-05 23.4 0.0 0.00019 21.7 0.0 1.9 2 1 0 2 2 2 1 RasGEF domain UPF0139 PF03669.13 EGD95544.1 - 1.4e-08 34.5 0.1 1.7e-08 34.2 0.1 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0139) DNA_pol_B PF00136.21 EGD95545.1 - 1.7e-100 336.9 0.1 3.8e-100 335.8 0.0 1.7 2 0 0 2 2 2 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 EGD95545.1 - 5.4e-18 65.2 0.0 8.1e-13 48.2 0.0 2.7 2 0 0 2 2 2 2 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.6 EGD95545.1 - 5e-17 62.1 9.1 5e-17 62.1 9.1 2.3 2 0 0 2 2 2 1 C4-type zinc-finger of DNA polymerase delta DUF1744 PF08490.12 EGD95545.1 - 0.01 14.5 0.0 0.017 13.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1744) HTH_ABP1_N PF18107.1 EGD95545.1 - 1.9 8.3 4.0 1.3 8.8 0.7 2.5 2 0 0 2 2 2 0 Fission yeast centromere protein N-terminal domain Slu7 PF11708.8 EGD95546.1 - 3.6e-84 282.7 17.4 3.6e-84 282.7 17.4 2.3 2 0 0 2 2 2 1 Pre-mRNA splicing Prp18-interacting factor zf-CCHC_4 PF14392.6 EGD95546.1 - 0.019 14.7 0.5 0.042 13.6 0.5 1.6 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC PF00098.23 EGD95546.1 - 0.29 11.3 2.8 0.57 10.4 2.8 1.4 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_5 PF14787.6 EGD95546.1 - 1.2 8.9 4.5 2.6 7.8 4.5 1.5 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger Ribosomal_L37e PF01907.19 EGD95547.1 - 4.8e-24 84.3 6.2 7.7e-24 83.6 6.2 1.3 1 0 0 1 1 1 1 Ribosomal protein L37e DZR PF12773.7 EGD95547.1 - 0.036 14.1 0.8 0.063 13.3 0.8 1.3 1 0 0 1 1 1 0 Double zinc ribbon ELP6 PF09807.9 EGD95548.1 - 1.8e-13 50.5 0.0 2e-07 30.7 0.0 2.1 2 0 0 2 2 2 2 Elongation complex protein 6 ATPase PF06745.13 EGD95548.1 - 0.12 11.7 0.0 0.45 9.8 0.0 1.7 2 0 0 2 2 2 0 KaiC RdRP PF05183.12 EGD95549.1 - 1.3e-194 648.2 0.0 1.7e-194 647.8 0.0 1.1 1 0 0 1 1 1 1 RNA dependent RNA polymerase RRM_1 PF00076.22 EGD95549.1 - 0.0036 17.1 0.0 0.012 15.4 0.0 1.9 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Mur_ligase_C PF02875.21 EGD95549.1 - 0.18 12.1 0.1 1.8 8.9 0.0 2.5 2 0 0 2 2 2 0 Mur ligase family, glutamate ligase domain AA_permease PF00324.21 EGD95550.1 - 4.4e-138 460.9 42.0 5.3e-138 460.6 42.0 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EGD95550.1 - 5.4e-37 127.6 45.6 6.6e-37 127.3 45.6 1.1 1 0 0 1 1 1 1 Amino acid permease DDE_Tnp_1_assoc PF13808.6 EGD95550.1 - 0.11 12.5 0.0 3.3 7.8 0.0 2.6 2 0 0 2 2 2 0 DDE_Tnp_1-associated Sulfate_transp PF00916.20 EGD95551.1 - 1.9e-117 392.2 17.8 2.3e-117 392.0 17.8 1.1 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 EGD95551.1 - 5e-08 32.6 0.0 1e-07 31.6 0.0 1.5 1 0 0 1 1 1 1 STAS domain MFS_MOT1 PF16983.5 EGD95551.1 - 3.8e-05 24.0 3.4 3.8e-05 24.0 3.4 2.9 2 1 0 2 2 2 2 Molybdate transporter of MFS superfamily FAD-oxidase_C PF02913.19 EGD95552.1 - 1.9e-58 198.0 0.0 2.5e-58 197.6 0.0 1.2 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 EGD95552.1 - 7e-35 119.8 0.1 2.3e-34 118.1 0.0 2.0 2 0 0 2 2 2 1 FAD binding domain Ribosomal_S4e PF00900.20 EGD95553.1 - 8.7e-37 124.9 0.2 1.8e-36 123.9 0.2 1.5 1 0 0 1 1 1 1 Ribosomal family S4e 40S_S4_C PF16121.5 EGD95553.1 - 1.7e-24 85.2 0.0 3e-24 84.4 0.0 1.4 1 0 0 1 1 1 1 40S ribosomal protein S4 C-terminus RS4NT PF08071.12 EGD95553.1 - 1.2e-18 66.9 7.0 2.4e-18 66.0 7.0 1.5 1 0 0 1 1 1 1 RS4NT (NUC023) domain S4 PF01479.25 EGD95553.1 - 1.1e-05 25.0 0.0 2.1e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 S4 domain KOW PF00467.29 EGD95553.1 - 0.0047 16.8 1.1 0.0047 16.8 1.1 3.1 3 0 0 3 3 3 1 KOW motif Sipho_tail PF05709.11 EGD95553.1 - 0.1 12.0 0.0 0.24 10.8 0.0 1.5 1 1 0 1 1 1 0 Phage tail protein MATalpha_HMGbox PF04769.12 EGD95555.1 - 2e-33 115.4 0.0 2.9e-33 114.9 0.0 1.3 1 0 0 1 1 1 1 Mating-type protein MAT alpha 1 HMG-box DUF3525 PF12039.8 EGD95555.1 - 0.17 10.6 0.0 0.27 9.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3525) Glyco_hydro_72 PF03198.14 EGD95556.1 - 0.085 12.1 0.0 0.13 11.5 0.0 1.2 1 0 0 1 1 1 0 Glucanosyltransferase Exo_endo_phos PF03372.23 EGD95557.1 - 2.3e-12 47.0 0.0 3.6e-12 46.3 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family zf-GRF PF06839.12 EGD95557.1 - 0.001 19.1 0.2 0.0026 17.8 0.2 1.7 1 0 0 1 1 1 1 GRF zinc finger COX6A PF02046.15 EGD95558.1 - 3.9e-52 175.5 1.2 4.7e-52 175.2 1.2 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIa I_LWEQ PF01608.17 EGD95559.1 - 1.5e-56 190.9 8.3 1.5e-56 190.9 8.3 6.2 3 2 2 7 7 7 2 I/LWEQ domain ANTH PF07651.16 EGD95559.1 - 5.1e-55 186.4 0.0 5.1e-55 186.4 0.0 2.8 2 1 0 2 2 2 1 ANTH domain TcdB_N PF12918.7 EGD95559.1 - 0.09 13.1 6.0 0.14 12.5 3.1 3.1 2 0 0 2 2 2 0 TcdB toxin N-terminal helical domain MMM1 PF10296.9 EGD95560.1 - 0.8 8.7 2.5 0.61 9.1 0.0 1.9 2 1 1 3 3 3 0 Maintenance of mitochondrial morphology protein 1 Hemerythrin PF01814.23 EGD95561.1 - 8.2e-13 49.1 0.1 1.2e-12 48.6 0.1 1.3 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain DUF5358 PF17311.2 EGD95561.1 - 0.034 14.2 0.1 0.045 13.8 0.1 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5358) MATalpha_HMGbox PF04769.12 EGD95561.1 - 0.065 12.5 0.0 0.09 12.1 0.0 1.3 1 0 0 1 1 1 0 Mating-type protein MAT alpha 1 HMG-box SKG6 PF08693.10 EGD95562.1 - 0.00055 19.3 0.2 0.001 18.4 0.2 1.4 1 0 0 1 1 1 1 Transmembrane alpha-helix domain TMEM51 PF15345.6 EGD95562.1 - 0.043 13.6 0.0 0.067 13.0 0.0 1.3 1 0 0 1 1 1 0 Transmembrane protein 51 Mid2 PF04478.12 EGD95562.1 - 0.079 12.8 0.0 0.14 12.0 0.0 1.5 1 0 0 1 1 1 0 Mid2 like cell wall stress sensor Med12 PF09497.10 EGD95563.1 - 2.7e-28 98.0 0.1 1e-27 96.2 0.1 2.1 2 0 0 2 2 2 1 Transcription mediator complex subunit Med12 Kv2channel PF03521.14 EGD95563.1 - 0.0084 15.5 2.9 0.014 14.8 2.9 1.3 1 0 0 1 1 1 1 Kv2 voltage-gated K+ channel Med12-LCEWAV PF12145.8 EGD95563.1 - 0.019 13.8 0.1 0.074 11.9 0.0 1.9 1 1 1 2 2 2 0 Eukaryotic Mediator 12 subunit domain CIA30 PF08547.12 EGD95564.1 - 3.5e-39 134.4 0.0 3.7e-25 88.8 0.0 2.2 2 0 0 2 2 2 2 Complex I intermediate-associated protein 30 (CIA30) SAICAR_synt PF01259.18 EGD95565.1 - 2.9e-96 322.0 0.0 3.5e-96 321.7 0.0 1.1 1 0 0 1 1 1 1 SAICAR synthetase Collectrin PF16959.5 EGD95565.1 - 0.033 14.0 0.0 0.053 13.3 0.0 1.2 1 0 0 1 1 1 0 Renal amino acid transporter DUF3439 PF11921.8 EGD95565.1 - 1.7 8.6 5.9 2 8.4 4.5 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) ANAPC5 PF12862.7 EGD95566.1 - 8.1e-31 106.0 1.7 1.5e-30 105.1 0.4 2.1 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 5 TPR_12 PF13424.6 EGD95566.1 - 5.4e-05 23.4 5.0 0.5 10.7 0.0 4.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_MalT PF17874.1 EGD95566.1 - 0.001 18.5 0.1 0.0025 17.3 0.1 1.7 1 0 0 1 1 1 1 MalT-like TPR region TPR_19 PF14559.6 EGD95566.1 - 0.0012 19.3 3.2 0.037 14.5 0.1 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 EGD95566.1 - 0.0024 18.5 0.8 1.7 9.3 0.0 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 EGD95566.1 - 0.038 14.0 0.1 8.9 6.6 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.17 EGD95566.1 - 0.046 13.9 0.2 25 5.3 0.0 3.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.28 EGD95566.1 - 0.089 12.6 0.2 11 6.1 0.1 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_4 PF07721.14 EGD95566.1 - 0.17 12.6 4.0 15 6.6 0.0 4.9 5 0 0 5 5 5 0 Tetratricopeptide repeat SUI1 PF01253.22 EGD95567.1 - 1.2e-27 96.3 3.9 1.6e-27 95.8 3.9 1.2 1 0 0 1 1 1 1 Translation initiation factor SUI1 GlcNAc-1_reg PF18440.1 EGD95567.1 - 0.051 13.8 0.1 0.083 13.1 0.1 1.2 1 0 0 1 1 1 0 Putative GlcNAc-1 phosphotransferase regulatory domain EOS1 PF12326.8 EGD95568.1 - 9.2e-13 48.5 14.8 1.4e-12 47.9 11.9 2.1 1 1 1 2 2 2 1 N-glycosylation protein MBA1 PF07961.11 EGD95569.1 - 3.9e-08 32.6 0.1 7.7e-08 31.7 0.1 1.4 1 1 0 1 1 1 1 MBA1-like protein SSF PF00474.17 EGD95570.1 - 5.4e-08 32.1 31.4 2.7e-07 29.8 31.4 2.1 1 1 0 1 1 1 1 Sodium:solute symporter family RhoGAP PF00620.27 EGD95571.1 - 4.1e-48 163.1 0.0 9.5e-48 161.9 0.0 1.6 1 0 0 1 1 1 1 RhoGAP domain FCH PF00611.23 EGD95571.1 - 6.7e-13 48.7 0.7 6.7e-13 48.7 0.7 2.9 2 1 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain OmpH PF03938.14 EGD95571.1 - 1.3 9.4 15.6 7.6 6.9 14.2 2.4 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) V-ATPase_G_2 PF16999.5 EGD95571.1 - 6.4 7.2 15.5 1.7 9.1 3.1 3.1 3 0 0 3 3 3 0 Vacuolar (H+)-ATPase G subunit ABM PF03992.16 EGD95572.1 - 3.7e-14 52.6 0.0 4.2e-14 52.4 0.0 1.1 1 0 0 1 1 1 1 Antibiotic biosynthesis monooxygenase ADPRTs_Tse2 PF18648.1 EGD95575.1 - 0.0054 16.8 0.0 0.12 12.4 0.0 2.2 2 0 0 2 2 2 2 Tse2 ADP-ribosyltransferase toxins ADPRTs_Tse2 PF18648.1 EGD95576.1 - 0.00048 20.2 0.0 0.00088 19.3 0.0 1.4 1 1 0 1 1 1 1 Tse2 ADP-ribosyltransferase toxins AAA PF00004.29 EGD95579.1 - 1.8e-21 76.9 0.0 4.3e-21 75.7 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 EGD95579.1 - 5.3e-05 23.0 0.0 0.00014 21.6 0.0 1.7 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EGD95579.1 - 0.00034 21.0 1.3 0.0019 18.6 0.7 2.7 2 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 EGD95579.1 - 0.00034 20.9 0.2 0.019 15.2 0.0 2.8 1 1 1 2 2 2 1 AAA domain AAA_5 PF07728.14 EGD95579.1 - 0.00064 19.7 0.0 0.0025 17.8 0.0 2.1 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_17 PF13207.6 EGD95579.1 - 0.018 15.4 0.0 0.07 13.6 0.0 1.9 1 1 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 EGD95579.1 - 0.027 14.2 0.0 0.058 13.1 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_18 PF13238.6 EGD95579.1 - 0.038 14.5 0.0 0.099 13.2 0.0 1.8 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 EGD95579.1 - 0.089 12.2 0.1 0.26 10.7 0.1 1.8 1 1 1 2 2 2 0 Magnesium chelatase, subunit ChlI MMS19_C PF12460.8 EGD95579.1 - 0.095 11.8 0.0 0.17 10.9 0.0 1.3 1 0 0 1 1 1 0 RNAPII transcription regulator C-terminal RNA_helicase PF00910.22 EGD95579.1 - 0.1 13.0 0.0 0.31 11.5 0.0 1.8 1 0 0 1 1 1 0 RNA helicase DEAD PF00270.29 EGD95579.1 - 0.12 12.2 0.1 4 7.2 0.0 2.3 1 1 0 2 2 2 0 DEAD/DEAH box helicase AAA_33 PF13671.6 EGD95579.1 - 0.16 12.2 0.0 0.34 11.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain L51_S25_CI-B8 PF05047.16 EGD95580.1 - 0.028 14.4 0.0 0.079 12.9 0.0 1.7 2 0 0 2 2 2 0 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain GTP_EFTU PF00009.27 EGD95581.1 - 0.15 11.6 0.0 0.24 10.9 0.0 1.2 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain SpvD PF05563.12 EGD95584.1 - 0.062 12.9 0.0 0.063 12.9 0.0 1.1 1 0 0 1 1 1 0 Salmonella plasmid virulence protein SpvD Kdo PF06293.14 EGD95585.1 - 0.00011 21.6 0.0 0.00022 20.6 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.25 EGD95585.1 - 0.00017 21.1 0.0 0.00038 19.9 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.23 EGD95585.1 - 0.0014 18.6 0.1 0.0014 18.6 0.1 2.8 2 1 1 3 3 3 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EGD95585.1 - 0.06 12.9 0.3 0.14 11.7 0.0 1.7 2 0 0 2 2 2 0 Choline/ethanolamine kinase ARGLU PF15346.6 EGD95585.1 - 1.1 9.1 14.0 2.8 7.8 14.0 1.7 1 0 0 1 1 1 0 Arginine and glutamate-rich 1 ORC_WH_C PF18137.1 EGD95585.1 - 1.4 9.0 4.7 3.5 7.7 4.7 1.6 1 0 0 1 1 1 0 Origin recognition complex winged helix C-terminal MAGE_N PF12440.8 EGD95585.1 - 4.2 8.1 19.3 3.3 8.5 6.1 2.5 2 0 0 2 2 2 0 Melanoma associated antigen family N terminal Casc1_N PF15927.5 EGD95585.1 - 7.4 6.2 12.5 5.3 6.7 10.6 1.7 2 0 0 2 2 2 0 Cancer susceptibility candidate 1 N-terminus Pkinase_fungal PF17667.1 EGD95586.1 - 2.9e-45 154.8 0.0 3.2e-45 154.6 0.0 1.0 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EGD95589.1 - 1.6e-11 44.6 0.0 3.9e-11 43.3 0.0 1.6 1 1 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EGD95589.1 - 0.0026 17.4 0.0 0.0047 16.5 0.0 1.5 1 0 0 1 1 1 1 Choline/ethanolamine kinase MFS_1 PF07690.16 EGD95590.1 - 1.5e-45 155.7 44.0 1.5e-45 155.7 44.0 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily FPN1 PF06963.12 EGD95590.1 - 0.0001 21.0 1.5 0.00015 20.5 0.0 1.9 2 0 0 2 2 2 1 Ferroportin1 (FPN1) Sugar_tr PF00083.24 EGD95590.1 - 0.00021 20.3 23.2 0.0011 17.9 23.2 2.1 1 1 0 1 1 1 1 Sugar (and other) transporter Wyosine_form PF08608.12 EGD95591.1 - 5.1e-22 78.0 0.0 1.1e-21 77.0 0.0 1.6 1 0 0 1 1 1 1 Wyosine base formation Radical_SAM PF04055.21 EGD95591.1 - 1.1e-21 78.0 0.0 3e-21 76.5 0.0 1.8 1 1 0 1 1 1 1 Radical SAM superfamily Flavodoxin_1 PF00258.25 EGD95591.1 - 0.023 14.9 0.3 0.71 10.1 0.3 2.5 1 1 0 1 1 1 0 Flavodoxin Pro_dh PF01619.18 EGD95592.1 - 3.1e-64 217.4 4.1 4e-64 217.0 4.1 1.1 1 0 0 1 1 1 1 Proline dehydrogenase Hydrolase PF00702.26 EGD95592.1 - 0.049 13.9 0.4 2.9 8.1 0.1 2.2 1 1 1 2 2 2 0 haloacid dehalogenase-like hydrolase Aldedh PF00171.22 EGD95593.1 - 5.5e-98 328.5 0.0 6.2e-98 328.3 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family OCD_Mu_crystall PF02423.15 EGD95594.1 - 1e-10 41.1 0.0 3e-05 23.1 0.0 2.8 2 1 0 2 2 2 2 Ornithine cyclodeaminase/mu-crystallin family Shikimate_DH PF01488.20 EGD95594.1 - 1.1e-05 25.5 0.0 0.092 12.8 0.0 2.6 2 0 0 2 2 2 2 Shikimate / quinate 5-dehydrogenase 2-Hacid_dh_C PF02826.19 EGD95594.1 - 0.083 12.3 0.3 0.49 9.7 0.0 2.4 4 0 0 4 4 4 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Zn_clus PF00172.18 EGD95595.1 - 2.1e-05 24.5 10.0 3.2e-05 23.9 10.0 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Amino_oxidase PF01593.24 EGD95596.1 - 3.7e-44 151.8 0.0 1.3e-43 150.0 0.0 1.7 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EGD95596.1 - 1.3e-12 47.7 0.0 2.8e-12 46.7 0.0 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 EGD95596.1 - 0.00014 22.4 0.4 0.0012 19.3 0.2 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EGD95596.1 - 0.00015 21.1 0.1 0.00061 19.1 0.0 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EGD95596.1 - 0.00021 20.5 0.1 0.0003 20.0 0.1 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A FAD_binding_3 PF01494.19 EGD95596.1 - 0.00038 19.8 1.0 0.00065 19.1 1.0 1.2 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 EGD95596.1 - 0.0024 16.6 0.2 0.0036 16.1 0.2 1.2 1 0 0 1 1 1 1 HI0933-like protein DAO PF01266.24 EGD95596.1 - 0.0064 16.1 7.5 0.026 14.1 4.2 2.8 2 1 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EGD95596.1 - 0.0099 15.0 0.3 0.014 14.5 0.3 1.2 1 0 0 1 1 1 1 FAD binding domain NAD_binding_9 PF13454.6 EGD95596.1 - 0.015 15.3 1.1 0.76 9.8 0.2 2.3 2 0 0 2 2 2 0 FAD-NAD(P)-binding 3HCDH_N PF02737.18 EGD95596.1 - 0.015 15.2 0.1 0.024 14.5 0.1 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Lycopene_cycl PF05834.12 EGD95596.1 - 0.015 14.3 0.2 0.056 12.5 0.1 1.8 2 0 0 2 2 2 0 Lycopene cyclase protein FAD_oxidored PF12831.7 EGD95596.1 - 0.063 12.6 0.0 0.1 11.9 0.0 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase Thi4 PF01946.17 EGD95596.1 - 0.12 11.6 0.1 0.2 10.9 0.1 1.2 1 0 0 1 1 1 0 Thi4 family AlaDh_PNT_C PF01262.21 EGD95596.1 - 0.25 10.6 0.0 0.41 9.9 0.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain LEA_6 PF10714.9 EGD95597.1 - 0.4 10.8 3.9 0.97 9.5 0.7 2.6 2 0 0 2 2 2 0 Late embryogenesis abundant protein 18 Metallophos PF00149.28 EGD95598.1 - 2e-06 28.5 0.0 3.1e-06 27.9 0.0 1.3 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EGD95598.1 - 3e-06 27.5 0.0 0.00046 20.4 0.0 2.1 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain DUF2183 PF09949.9 EGD95599.1 - 6.2e-32 109.9 0.0 2.1e-31 108.1 0.0 2.0 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2183) HrpB2 PF09487.10 EGD95599.1 - 0.0026 18.2 0.2 0.0069 16.8 0.2 1.7 1 0 0 1 1 1 1 Bacterial type III secretion protein (HrpB2) CarboxypepD_reg PF13620.6 EGD95599.1 - 0.044 14.0 0.1 0.39 11.0 0.0 2.4 2 0 0 2 2 2 0 Carboxypeptidase regulatory-like domain RPAP1_N PF08621.10 EGD95599.1 - 0.11 12.3 2.4 0.2 11.5 2.4 1.4 1 0 0 1 1 1 0 RPAP1-like, N-terminal PI31_Prot_N PF11566.8 EGD95600.1 - 8.4e-37 126.5 0.0 1.3e-36 125.9 0.0 1.1 1 0 0 1 1 1 1 PI31 proteasome regulator N-terminal PI31_Prot_C PF08577.11 EGD95600.1 - 1.9e-18 67.4 12.7 1.9e-18 67.4 12.7 2.8 3 0 0 3 3 3 1 PI31 proteasome regulator Metallophos PF00149.28 EGD95601.1 - 1.6e-37 130.0 0.4 2.7e-37 129.3 0.4 1.4 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase Glyco_hydro_65N PF03636.15 EGD95601.1 - 0.098 12.3 0.0 0.15 11.7 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 65, N-terminal domain adh_short_C2 PF13561.6 EGD95602.1 - 3.3e-51 174.1 0.9 4.1e-51 173.8 0.9 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EGD95602.1 - 2.7e-46 157.5 0.8 3.6e-46 157.1 0.8 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EGD95602.1 - 2.5e-11 43.8 0.2 3.5e-11 43.3 0.2 1.1 1 0 0 1 1 1 1 KR domain 2-Hacid_dh_C PF02826.19 EGD95602.1 - 0.02 14.3 0.1 0.034 13.5 0.1 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain THF_DHG_CYH_C PF02882.19 EGD95602.1 - 0.022 14.1 0.2 0.034 13.5 0.2 1.3 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Shikimate_DH PF01488.20 EGD95602.1 - 0.023 14.7 0.4 0.04 14.0 0.4 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase DUF1776 PF08643.10 EGD95602.1 - 0.032 13.6 0.0 0.045 13.1 0.0 1.2 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) Epimerase PF01370.21 EGD95602.1 - 0.073 12.5 0.4 4.2 6.8 0.2 2.3 2 1 0 2 2 2 0 NAD dependent epimerase/dehydratase family Pyr_redox PF00070.27 EGD95602.1 - 0.1 13.2 0.5 0.1 13.2 0.5 1.8 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase DUF3112 PF11309.8 EGD95603.1 - 3.2e-12 46.4 9.2 4e-10 39.5 0.7 2.6 2 2 1 2 2 2 2 Protein of unknown function (DUF3112) TPR_1 PF00515.28 EGD95604.1 - 9.1e-08 31.6 0.6 0.00034 20.3 0.0 3.5 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.6 EGD95604.1 - 8.4e-05 22.2 0.1 0.00022 20.8 0.1 1.8 1 0 0 1 1 1 1 TPR repeat TPR_2 PF07719.17 EGD95604.1 - 8.5e-05 22.4 3.3 0.03 14.4 0.0 4.0 4 1 0 4 4 4 1 Tetratricopeptide repeat TPR_12 PF13424.6 EGD95604.1 - 0.00015 22.0 0.5 0.00041 20.6 0.1 2.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.6 EGD95604.1 - 0.00053 19.8 0.8 0.13 12.3 0.1 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat ELH PF02323.15 EGD95604.1 - 0.0011 18.3 0.4 0.0019 17.6 0.1 1.4 2 0 0 2 2 2 1 Egg-laying hormone precursor TPR_14 PF13428.6 EGD95604.1 - 0.0075 17.0 0.4 0.22 12.4 0.0 2.9 3 0 0 3 3 3 1 Tetratricopeptide repeat Pkinase PF00069.25 EGD95605.1 - 4.8e-25 88.4 0.0 1.3e-23 83.7 0.0 2.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD95605.1 - 1.2e-13 50.9 0.0 1.1e-12 47.8 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase HAD_2 PF13419.6 EGD95606.1 - 1.5e-13 51.3 0.0 2.4e-13 50.5 0.0 1.4 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EGD95606.1 - 1e-06 29.2 0.0 1.3e-05 25.6 0.0 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EGD95606.1 - 0.022 14.8 0.0 0.1 12.7 0.0 2.1 2 0 0 2 2 2 0 HAD-hyrolase-like WD40 PF00400.32 EGD95610.1 - 0.053 14.4 12.9 20 6.3 1.3 6.8 6 2 0 6 6 6 0 WD domain, G-beta repeat Lactonase PF10282.9 EGD95610.1 - 0.11 11.7 0.0 0.17 11.1 0.0 1.2 1 0 0 1 1 1 0 Lactonase, 7-bladed beta-propeller Nucleoporin_FG PF13634.6 EGD95611.1 - 1.7e-07 32.0 70.2 0.0026 18.6 30.5 3.5 1 1 2 3 3 3 3 Nucleoporin FG repeat region DUF1664 PF07889.12 EGD95611.1 - 0.015 15.4 0.9 2.2 8.3 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Cpn10 PF00166.21 EGD95613.1 - 3.9e-27 94.2 0.0 4.4e-27 94.0 0.0 1.0 1 0 0 1 1 1 1 Chaperonin 10 Kd subunit Fip1 PF05182.13 EGD95614.1 - 1.1e-20 72.8 1.9 2e-20 72.0 1.9 1.4 1 0 0 1 1 1 1 Fip1 motif DNA_pol_phi PF04931.13 EGD95614.1 - 4.1 5.4 7.4 5.4 5.0 7.4 1.1 1 0 0 1 1 1 0 DNA polymerase phi Lin-8 PF03353.15 EGD95614.1 - 5.2 6.5 6.9 7 6.1 6.9 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Nop14 PF04147.12 EGD95614.1 - 7.8 4.6 9.5 10 4.2 9.5 1.1 1 0 0 1 1 1 0 Nop14-like family XAP5 PF04921.14 EGD95615.1 - 5.1e-45 154.3 0.0 1.6e-44 152.6 0.0 1.9 1 1 1 2 2 2 1 XAP5, circadian clock regulator DUF4604 PF15377.6 EGD95615.1 - 0.0034 17.8 6.0 0.0061 17.0 6.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4604) zf-RING_5 PF14634.6 EGD95616.1 - 1.5e-08 34.5 8.1 3.2e-08 33.4 8.1 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 EGD95616.1 - 0.00038 20.3 4.2 0.00096 19.0 4.2 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EGD95616.1 - 0.00041 20.3 1.7 0.00041 20.3 1.7 1.9 1 1 1 2 2 2 1 RING-type zinc-finger CCCAP PF15964.5 EGD95616.1 - 0.00041 18.8 3.3 0.00061 18.2 3.3 1.3 1 0 0 1 1 1 1 Centrosomal colon cancer autoantigen protein family Prok-RING_4 PF14447.6 EGD95616.1 - 0.00049 19.9 5.9 0.00097 18.9 5.9 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 EGD95616.1 - 0.00086 19.6 6.8 0.0021 18.4 6.8 1.7 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EGD95616.1 - 0.0012 18.6 4.1 0.0053 16.6 4.2 2.0 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) IFT57 PF10498.9 EGD95616.1 - 0.0037 16.3 1.8 0.0047 15.9 1.8 1.2 1 0 0 1 1 1 1 Intra-flagellar transport protein 57 DUF4472 PF14739.6 EGD95616.1 - 0.004 17.9 4.3 0.0065 17.2 4.3 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4472) ZapB PF06005.12 EGD95616.1 - 0.0094 16.4 4.3 0.016 15.6 4.3 1.4 1 0 0 1 1 1 1 Cell division protein ZapB RmuC PF02646.16 EGD95616.1 - 0.011 14.8 3.7 0.016 14.3 3.7 1.3 1 0 0 1 1 1 0 RmuC family Prefoldin PF02996.17 EGD95616.1 - 0.016 15.1 1.4 0.029 14.3 1.4 1.5 1 0 0 1 1 1 0 Prefoldin subunit DUF4403 PF14356.6 EGD95616.1 - 0.017 13.8 0.2 0.029 13.1 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4403) DUF1664 PF07889.12 EGD95616.1 - 0.019 15.0 3.5 0.034 14.2 3.2 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) Mod_r PF07200.13 EGD95616.1 - 0.027 14.6 6.7 0.042 13.9 6.7 1.3 1 0 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein zf-C3HC4_4 PF15227.6 EGD95616.1 - 0.041 14.0 5.6 0.043 14.0 4.3 1.8 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_6 PF14835.6 EGD95616.1 - 0.042 13.7 2.9 0.093 12.6 2.9 1.6 1 0 0 1 1 1 0 zf-RING of BARD1-type protein Phage_Mu_Gam PF07352.12 EGD95616.1 - 0.055 13.4 2.8 0.09 12.7 2.8 1.3 1 0 0 1 1 1 0 Bacteriophage Mu Gam like protein DUF87 PF01935.17 EGD95616.1 - 0.089 12.9 1.6 0.13 12.3 1.6 1.2 1 0 0 1 1 1 0 Helicase HerA, central domain Exonuc_VII_L PF02601.15 EGD95616.1 - 0.11 12.1 3.3 0.14 11.7 3.3 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Sec23_helical PF04815.15 EGD95616.1 - 0.11 12.3 4.5 0.56 10.1 1.8 2.9 2 1 0 2 2 2 0 Sec23/Sec24 helical domain zf-rbx1 PF12678.7 EGD95616.1 - 0.13 12.5 3.6 0.36 11.1 3.6 1.8 1 0 0 1 1 1 0 RING-H2 zinc finger domain OmpH PF03938.14 EGD95616.1 - 0.2 12.0 6.3 0.31 11.4 6.3 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) TSC22 PF01166.18 EGD95616.1 - 0.2 12.0 2.8 0.5 10.7 2.5 1.9 1 1 0 1 1 1 0 TSC-22/dip/bun family CEP19 PF14933.6 EGD95616.1 - 0.56 10.5 6.7 0.96 9.7 6.7 1.3 1 0 0 1 1 1 0 CEP19-like protein zf-P11 PF03854.14 EGD95616.1 - 0.85 9.3 4.3 2.3 7.9 4.3 1.8 1 0 0 1 1 1 0 P-11 zinc finger DZR PF12773.7 EGD95616.1 - 1.1 9.3 6.1 5.5 7.1 6.1 2.1 1 1 0 1 1 1 0 Double zinc ribbon DUF4407 PF14362.6 EGD95616.1 - 1.7 8.0 6.0 2.1 7.6 6.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DNA_ligase_ZBD PF03119.16 EGD95616.1 - 2.7 8.1 5.4 25 5.0 0.5 2.6 2 0 0 2 2 2 0 NAD-dependent DNA ligase C4 zinc finger domain Ly49 PF08391.10 EGD95616.1 - 3.5 8.0 7.3 7.6 6.9 7.0 1.6 1 1 0 1 1 1 0 Ly49-like protein, N-terminal region IBR PF01485.21 EGD95616.1 - 9.9 6.5 8.7 2.7 8.3 2.7 2.6 1 1 0 2 2 2 0 IBR domain, a half RING-finger domain zf-C3HC4_3 PF13920.6 EGD95617.1 - 2.1e-09 37.1 12.2 3.5e-09 36.4 12.2 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EGD95617.1 - 0.13 12.2 13.1 0.23 11.4 13.1 1.4 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 Asp PF00026.23 EGD95618.1 - 4e-15 56.1 0.2 5.8e-15 55.5 0.2 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease Phage_holin_2_4 PF16082.5 EGD95618.1 - 0.0072 16.0 0.0 0.015 15.0 0.0 1.5 1 0 0 1 1 1 1 Bacteriophage holin family, superfamily II-like TAXi_N PF14543.6 EGD95618.1 - 0.017 15.4 0.3 0.053 13.7 0.0 1.9 2 0 0 2 2 2 0 Xylanase inhibitor N-terminal Mid2 PF04478.12 EGD95618.1 - 0.091 12.6 0.1 0.2 11.5 0.1 1.5 1 0 0 1 1 1 0 Mid2 like cell wall stress sensor Podoplanin PF05808.11 EGD95618.1 - 2.6 8.1 6.0 3 7.9 0.4 2.2 2 0 0 2 2 2 0 Podoplanin SPX PF03105.19 EGD95620.1 - 9.3 6.0 11.3 14 5.5 11.3 1.3 1 0 0 1 1 1 0 SPX domain ThiF PF00899.21 EGD95621.1 - 2e-12 47.0 0.0 2.2e-10 40.3 0.0 2.9 1 1 0 1 1 1 1 ThiF family Rib_5-P_isom_A PF06026.14 EGD95622.1 - 4.9e-42 143.5 0.0 7.8e-42 142.8 0.0 1.3 1 0 0 1 1 1 1 Ribose 5-phosphate isomerase A (phosphoriboisomerase A) ketoacyl-synt PF00109.26 EGD95623.1 - 7.1e-05 22.5 0.0 0.00011 21.9 0.0 1.3 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain WD40 PF00400.32 EGD95624.1 - 1e-08 35.6 0.1 0.12 13.2 0.1 4.8 5 0 0 5 5 5 3 WD domain, G-beta repeat SARS_X4 PF08779.10 EGD95624.1 - 0.14 12.4 0.0 1.4 9.1 0.0 2.5 3 0 0 3 3 3 0 SARS coronavirus X4 like ATP_bind_1 PF03029.17 EGD95625.1 - 6.3e-78 261.9 0.0 7.7e-78 261.6 0.0 1.1 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein AAA_31 PF13614.6 EGD95625.1 - 0.00098 19.1 0.0 0.17 11.8 0.0 2.3 1 1 0 1 1 1 1 AAA domain MeaB PF03308.16 EGD95625.1 - 0.0018 17.3 0.1 0.0039 16.2 0.0 1.5 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB MMR_HSR1 PF01926.23 EGD95625.1 - 0.0022 18.1 0.0 0.012 15.7 0.0 2.1 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_10 PF12846.7 EGD95625.1 - 0.0097 14.9 0.0 0.015 14.2 0.0 1.2 1 0 0 1 1 1 1 AAA-like domain Fer4_NifH PF00142.18 EGD95625.1 - 0.017 14.6 0.2 0.054 12.9 0.2 1.8 1 1 0 1 1 1 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family KTI12 PF08433.10 EGD95625.1 - 0.02 14.4 0.0 0.032 13.7 0.0 1.3 1 0 0 1 1 1 0 Chromatin associated protein KTI12 AAA_16 PF13191.6 EGD95625.1 - 0.027 14.8 0.0 0.042 14.2 0.0 1.6 1 1 0 1 1 1 0 AAA ATPase domain AAA_17 PF13207.6 EGD95625.1 - 0.052 14.0 0.2 0.13 12.7 0.1 1.7 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 EGD95625.1 - 0.057 13.2 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_22 PF13401.6 EGD95625.1 - 0.064 13.5 0.0 0.13 12.6 0.0 1.6 1 1 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EGD95625.1 - 0.075 13.4 0.0 0.15 12.5 0.0 1.5 1 0 0 1 1 1 0 RNA helicase AAA_30 PF13604.6 EGD95625.1 - 0.082 12.6 0.0 0.17 11.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 EGD95625.1 - 0.095 13.2 0.0 0.28 11.7 0.0 1.9 2 0 0 2 2 2 0 AAA domain CLP1_P PF16575.5 EGD95625.1 - 0.098 12.4 0.0 0.17 11.7 0.0 1.4 1 0 0 1 1 1 0 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_33 PF13671.6 EGD95625.1 - 0.19 11.9 0.0 0.35 11.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain RNase_P_Rpp14 PF01900.19 EGD95626.1 - 7.5e-39 132.1 0.0 9.5e-39 131.8 0.0 1.1 1 0 0 1 1 1 1 Rpp14/Pop5 family Citrate_synt PF00285.21 EGD95627.1 - 1.3e-19 70.5 0.0 1.7e-16 60.3 0.0 2.8 1 1 1 2 2 2 2 Citrate synthase, C-terminal domain CoA_binding PF02629.19 EGD95627.1 - 2.2e-18 66.7 0.1 8.9e-18 64.8 0.0 2.0 2 0 0 2 2 2 1 CoA binding domain Ligase_CoA PF00549.19 EGD95627.1 - 7.4e-13 48.6 0.1 1.3e-12 47.8 0.1 1.4 1 0 0 1 1 1 1 CoA-ligase Succ_CoA_lig PF13607.6 EGD95627.1 - 1.3e-05 25.0 0.1 0.00012 21.9 0.0 2.2 2 0 0 2 2 2 1 Succinyl-CoA ligase like flavodoxin domain Citrate_bind PF16114.5 EGD95628.1 - 2e-54 183.8 0.3 3e-54 183.2 0.3 1.2 1 0 0 1 1 1 1 ATP citrate lyase citrate-binding ATP-grasp_2 PF08442.10 EGD95628.1 - 1.4e-07 31.3 0.0 2e-07 30.8 0.0 1.2 1 0 0 1 1 1 1 ATP-grasp domain CFEM PF05730.11 EGD95630.1 - 1.9e-15 56.7 7.7 2.7e-15 56.2 7.7 1.2 1 0 0 1 1 1 1 CFEM domain MGC-24 PF05283.11 EGD95630.1 - 0.062 13.8 5.6 0.089 13.2 5.6 1.4 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin Amidase PF01425.21 EGD95633.1 - 4e-88 296.3 0.0 5.5e-88 295.9 0.0 1.2 1 0 0 1 1 1 1 Amidase RT_RNaseH_2 PF17919.1 EGD95635.1 - 0.08 13.0 0.0 0.14 12.2 0.0 1.4 1 0 0 1 1 1 0 RNase H-like domain found in reverse transcriptase ORC6 PF05460.13 EGD95636.1 - 1e-47 163.1 0.2 1.4e-47 162.7 0.2 1.2 1 0 0 1 1 1 1 Origin recognition complex subunit 6 (ORC6) DUF2336 PF10098.9 EGD95636.1 - 0.017 14.6 0.0 0.03 13.8 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein conserved in bacteria (DUF2336) Senescence_reg PF04520.13 EGD95636.1 - 0.13 13.1 3.0 0.48 11.3 0.7 2.3 2 0 0 2 2 2 0 Senescence regulator Q_salvage PF10343.9 EGD95637.1 - 2.5e-133 444.0 0.0 3e-133 443.7 0.0 1.1 1 0 0 1 1 1 1 Potential Queuosine, Q, salvage protein family ThiF PF00899.21 EGD95638.1 - 1.2e-73 247.4 0.0 1.8e-73 246.9 0.0 1.1 1 0 0 1 1 1 1 ThiF family UAE_UbL PF14732.6 EGD95638.1 - 1.4e-21 76.9 0.1 3.4e-21 75.6 0.1 1.7 1 0 0 1 1 1 1 Ubiquitin/SUMO-activating enzyme ubiquitin-like domain UBA_e1_thiolCys PF10585.9 EGD95638.1 - 4.5e-08 33.3 1.2 0.0013 18.7 0.1 2.4 1 1 1 2 2 2 2 Ubiquitin-activating enzyme active site NAD_binding_7 PF13241.6 EGD95638.1 - 0.00019 21.9 0.0 0.00077 19.9 0.0 2.1 2 0 0 2 2 2 1 Putative NAD(P)-binding Shikimate_DH PF01488.20 EGD95638.1 - 0.02 15.0 0.0 0.046 13.8 0.0 1.6 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase E2_bind PF08825.10 EGD95638.1 - 0.044 13.9 0.8 0.083 13.1 0.2 1.8 2 0 0 2 2 2 0 E2 binding domain Pyr_redox PF00070.27 EGD95638.1 - 0.054 14.1 0.1 7.2 7.2 0.0 2.6 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase adh_short_C2 PF13561.6 EGD95639.1 - 4.2e-32 111.6 2.5 4.9e-31 108.1 2.5 2.4 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EGD95639.1 - 7e-31 107.2 3.7 2.3e-16 59.8 0.1 2.8 2 1 0 2 2 2 2 short chain dehydrogenase KR PF08659.10 EGD95639.1 - 2.1e-07 31.0 0.0 2.1e-07 31.0 0.0 2.2 2 1 0 2 2 2 1 KR domain Epimerase PF01370.21 EGD95639.1 - 0.00026 20.5 0.1 0.00081 18.9 0.1 1.8 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 EGD95639.1 - 0.0063 15.7 0.0 0.01 15.0 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.12 EGD95639.1 - 0.0095 15.1 0.0 0.015 14.5 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein Pkinase PF00069.25 EGD95640.1 - 8.4e-07 28.6 0.0 2.6e-06 27.0 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain APH PF01636.23 EGD95640.1 - 2e-06 27.9 3.3 1.3e-05 25.2 0.0 2.7 3 0 0 3 3 3 1 Phosphotransferase enzyme family Kdo PF06293.14 EGD95640.1 - 0.00019 20.8 0.0 0.00041 19.7 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 EGD95640.1 - 0.003 17.2 0.2 0.017 14.7 0.0 2.2 3 0 0 3 3 3 1 Choline/ethanolamine kinase HSDR_N_2 PF13588.6 EGD95640.1 - 0.019 15.0 0.1 4 7.5 0.0 3.1 3 0 0 3 3 3 0 Type I restriction enzyme R protein N terminus (HSDR_N) UBA2_C PF16195.5 EGD95640.1 - 0.3 11.8 0.0 0.3 11.8 0.0 3.0 4 0 0 4 4 4 0 SUMO-activating enzyme subunit 2 C-terminus SR-25 PF10500.9 EGD95640.1 - 1.2 8.7 13.3 0.31 10.6 8.7 2.2 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Skp1_POZ PF03931.15 EGD95641.1 - 2.2e-09 37.3 0.0 2.8e-09 37.0 0.0 1.1 1 0 0 1 1 1 1 Skp1 family, tetramerisation domain Nif11 PF07862.11 EGD95641.1 - 0.074 13.4 0.0 0.14 12.5 0.0 1.3 1 0 0 1 1 1 0 Nif11 domain tRNA_int_end_N2 PF12928.7 EGD95642.1 - 2.4e-28 98.1 0.0 4.1e-28 97.4 0.0 1.4 1 0 0 1 1 1 1 tRNA-splicing endonuclease subunit sen54 N-term tRNA_int_endo_N PF02778.14 EGD95642.1 - 0.0063 16.2 0.0 0.012 15.2 0.0 1.4 1 0 0 1 1 1 1 tRNA intron endonuclease, N-terminal domain Arrestin_C PF02752.22 EGD95644.1 - 5.5e-13 49.5 0.0 1.7e-12 48.0 0.0 1.8 2 1 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain Pro_isomerase PF00160.21 EGD95645.1 - 1.8e-34 119.3 0.0 2.8e-34 118.7 0.0 1.3 1 1 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD zf-ZPR1 PF03367.13 EGD95646.1 - 8.1e-106 350.8 0.0 4.6e-54 182.6 0.0 2.2 2 0 0 2 2 2 2 ZPR1 zinc-finger domain HypA PF01155.19 EGD95646.1 - 0.026 14.5 1.3 1.3 9.1 0.1 2.5 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zinc-ribbons_6 PF07191.12 EGD95646.1 - 0.049 13.6 2.3 1.9 8.6 0.2 2.6 2 1 0 2 2 2 0 zinc-ribbons OrfB_Zn_ribbon PF07282.11 EGD95646.1 - 0.11 12.5 0.1 7 6.7 0.0 2.6 2 0 0 2 2 2 0 Putative transposase DNA-binding domain Cys_rich_KTR PF14205.6 EGD95646.1 - 0.24 11.2 0.8 1.3 8.9 0.1 2.3 2 0 0 2 2 2 0 Cysteine-rich KTR zf-ISL3 PF14690.6 EGD95646.1 - 0.38 11.4 5.6 34 5.2 0.6 3.4 3 0 0 3 3 3 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 Rpr2 PF04032.16 EGD95647.1 - 7.3e-12 45.4 2.6 7.3e-12 45.4 2.6 1.9 2 0 0 2 2 2 1 RNAse P Rpr2/Rpp21/SNM1 subunit domain zf-ribbon_3 PF13248.6 EGD95647.1 - 0.022 14.2 0.7 0.06 12.8 0.1 2.0 2 0 0 2 2 2 0 zinc-ribbon domain Zn-ribbon_8 PF09723.10 EGD95647.1 - 0.082 13.0 0.7 3.2 8.0 0.1 2.5 2 0 0 2 2 2 0 Zinc ribbon domain DUF4674 PF15719.5 EGD95647.1 - 6.8 6.7 16.5 32 4.5 13.1 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4674) DBR1 PF05011.13 EGD95648.1 - 4.6e-43 147.0 0.0 1.2e-42 145.6 0.0 1.8 1 0 0 1 1 1 1 Lariat debranching enzyme, C-terminal domain RTP1_C1 PF10363.9 EGD95649.1 - 1.6e-29 102.3 0.1 2.1e-28 98.8 0.0 2.8 3 0 0 3 3 3 1 Required for nuclear transport of RNA pol II C-terminus 1 RTP1_C2 PF10304.9 EGD95649.1 - 1.7e-10 40.4 0.0 3.7e-10 39.3 0.0 1.6 1 0 0 1 1 1 1 Required for nuclear transport of RNA pol II C-terminus 2 FliT PF05400.13 EGD95649.1 - 0.23 12.3 1.8 0.38 11.6 0.4 2.1 2 0 0 2 2 2 0 Flagellar protein FliT Polysacc_deac_1 PF01522.21 EGD95650.1 - 3e-27 95.0 0.0 6.6e-27 93.9 0.0 1.5 1 0 0 1 1 1 1 Polysaccharide deacetylase Chitin_bind_1 PF00187.19 EGD95650.1 - 4.6e-09 36.6 41.3 7.4e-05 23.1 16.3 2.5 2 0 0 2 2 2 2 Chitin recognition protein DUF2334 PF10096.9 EGD95650.1 - 0.062 12.9 0.0 0.09 12.4 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2334) RAD51_interact PF15696.5 EGD95651.1 - 0.037 14.1 0.1 0.12 12.5 0.1 1.9 1 0 0 1 1 1 0 RAD51 interacting motif FAD_binding_3 PF01494.19 EGD95652.1 - 6.2e-23 81.6 0.0 8.1e-23 81.2 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 EGD95652.1 - 1.1e-06 28.1 1.1 0.00045 19.5 0.1 2.5 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EGD95652.1 - 6.3e-06 26.7 0.5 0.00064 20.2 0.2 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EGD95652.1 - 0.001 18.8 2.1 0.008 15.8 1.4 2.2 2 1 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EGD95652.1 - 0.0027 16.9 0.7 0.0048 16.0 0.7 1.4 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 EGD95652.1 - 0.0055 16.9 0.4 0.012 15.8 0.4 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain SE PF08491.10 EGD95652.1 - 0.043 12.8 0.0 0.08 12.0 0.0 1.4 1 0 0 1 1 1 0 Squalene epoxidase Pyr_redox_3 PF13738.6 EGD95652.1 - 0.084 12.1 0.7 6.3 6.0 0.2 2.3 1 1 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.18 EGD95652.1 - 0.16 11.8 0.1 0.29 11.0 0.1 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Trp_halogenase PF04820.14 EGD95652.1 - 0.19 10.6 0.2 5.2 5.8 0.0 2.5 3 0 0 3 3 3 0 Tryptophan halogenase Trypsin_2 PF13365.6 EGD95653.1 - 0.0011 19.9 0.1 0.0061 17.5 0.1 2.0 1 1 0 1 1 1 1 Trypsin-like peptidase domain Peptidase_S7 PF00949.21 EGD95653.1 - 0.1 12.4 0.0 0.21 11.4 0.0 1.4 1 0 0 1 1 1 0 Peptidase S7, Flavivirus NS3 serine protease Peptidase_S46 PF10459.9 EGD95653.1 - 0.15 10.7 0.3 0.25 9.9 0.0 1.4 2 0 0 2 2 2 0 Peptidase S46 Clathrin PF00637.20 EGD95654.1 - 2e-20 73.1 2.8 1.2e-17 64.1 0.8 2.8 2 0 0 2 2 2 2 Region in Clathrin and VPS VPS11_C PF12451.8 EGD95654.1 - 4.9e-18 65.1 0.5 1.1e-17 64.0 0.5 1.6 1 0 0 1 1 1 1 Vacuolar protein sorting protein 11 C terminal zf-C3H2C3 PF17122.5 EGD95654.1 - 5.2e-07 29.6 8.1 9.6e-07 28.7 8.1 1.5 1 0 0 1 1 1 1 Zinc-finger zf-C3HC4_2 PF13923.6 EGD95654.1 - 4.5e-06 26.4 6.4 8.7e-06 25.5 6.4 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EGD95654.1 - 0.0002 21.2 5.7 0.00043 20.2 5.7 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 EGD95654.1 - 0.00045 20.5 6.4 0.00088 19.6 6.4 1.5 1 0 0 1 1 1 1 Ring finger domain TPR_11 PF13414.6 EGD95654.1 - 0.0014 18.2 1.3 0.0023 17.6 0.1 2.0 2 0 0 2 2 2 1 TPR repeat WD40_like PF17005.5 EGD95654.1 - 0.0021 17.5 0.2 0.041 13.2 0.0 2.4 3 0 0 3 3 3 1 WD40-like domain HPS3_N PF14761.6 EGD95654.1 - 0.0043 16.6 0.0 0.022 14.3 0.0 2.2 3 0 0 3 3 3 1 Hermansky-Pudlak syndrome 3 TPR_14 PF13428.6 EGD95654.1 - 0.0061 17.3 0.0 0.32 11.9 0.0 3.4 3 0 0 3 3 2 1 Tetratricopeptide repeat zf-rbx1 PF12678.7 EGD95654.1 - 0.0078 16.5 4.7 0.016 15.5 4.7 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger domain TPR_8 PF13181.6 EGD95654.1 - 0.026 14.7 0.1 1.3 9.5 0.1 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat zf-C3HC4 PF00097.25 EGD95654.1 - 0.056 13.3 5.5 0.11 12.4 5.5 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) TPR_2 PF07719.17 EGD95654.1 - 0.072 13.2 0.7 0.72 10.1 0.1 3.0 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_12 PF13424.6 EGD95654.1 - 0.11 12.9 1.1 1.3 9.3 0.1 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat zf-ANAPC11 PF12861.7 EGD95654.1 - 0.53 10.4 2.3 1.5 8.9 2.3 1.8 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.6 EGD95654.1 - 1.2 9.2 6.5 3 8.0 6.5 1.7 1 0 0 1 1 1 0 RING-type zinc-finger TPR_1 PF00515.28 EGD95654.1 - 1.4 8.8 3.5 3.2 7.7 0.1 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat adh_short_C2 PF13561.6 EGD95655.1 - 3e-61 207.0 0.1 3.4e-61 206.8 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EGD95655.1 - 2.7e-41 141.2 0.2 3.2e-41 140.9 0.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EGD95655.1 - 3.6e-14 53.1 0.1 5.2e-14 52.6 0.1 1.2 1 0 0 1 1 1 1 KR domain LktC PF06261.11 EGD95655.1 - 0.16 11.9 0.0 0.3 11.0 0.0 1.4 1 1 0 1 1 1 0 Actinobacillus actinomycetemcomitans leukotoxin activator LktC LRR_4 PF12799.7 EGD95657.1 - 1.5e-23 82.5 43.0 3.4e-05 24.1 1.5 9.1 8 1 0 9 9 9 7 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EGD95657.1 - 7.4e-20 70.5 43.3 6.2e-07 29.1 3.2 7.9 5 1 2 8 8 8 6 Leucine rich repeat LRR_9 PF14580.6 EGD95657.1 - 8.4e-11 41.7 10.3 5.2e-05 22.8 1.0 4.3 2 1 2 4 4 4 3 Leucine-rich repeat LRR_6 PF13516.6 EGD95657.1 - 3.5 7.9 29.4 1.8 8.8 1.3 9.1 9 1 0 10 10 10 0 Leucine Rich repeat IPK PF03770.16 EGD95658.1 - 6.4e-57 192.6 1.6 9e-57 192.1 0.0 2.1 2 1 0 2 2 2 1 Inositol polyphosphate kinase Pam17 PF08566.10 EGD95658.1 - 0.046 13.6 0.1 0.13 12.1 0.1 1.7 1 0 0 1 1 1 0 Mitochondrial import protein Pam17 DUF4100 PF13352.6 EGD95659.1 - 0.38 10.5 4.0 0.52 10.0 4.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4100) MFS_1 PF07690.16 EGD95660.1 - 2.9e-17 62.6 20.7 2.9e-17 62.6 20.7 2.2 2 0 0 2 2 2 1 Major Facilitator Superfamily Nodulin-like PF06813.13 EGD95660.1 - 0.0016 17.9 13.9 0.0066 16.0 0.9 3.5 4 0 0 4 4 4 2 Nodulin-like ERCC4 PF02732.15 EGD95661.1 - 5.9e-24 85.0 0.0 5.9e-24 85.0 0.0 2.8 1 1 2 3 3 3 1 ERCC4 domain SspN PF08177.11 EGD95661.1 - 0.073 13.0 0.9 0.26 11.3 0.0 2.4 2 0 0 2 2 2 0 Small acid-soluble spore protein N family Mre11_DNA_bind PF04152.14 EGD95662.1 - 6.6e-53 179.5 0.7 1.4e-52 178.4 0.7 1.6 1 0 0 1 1 1 1 Mre11 DNA-binding presumed domain Metallophos PF00149.28 EGD95662.1 - 2.8e-13 50.9 1.1 1.4e-12 48.5 0.7 2.1 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EGD95662.1 - 0.00035 20.8 0.0 0.0058 16.8 0.0 2.7 2 1 0 2 2 2 1 Calcineurin-like phosphoesterase superfamily domain CHIP_TPR_N PF18391.1 EGD95662.1 - 3.1 8.6 7.9 0.2 12.5 1.2 2.3 2 0 0 2 2 2 0 CHIP N-terminal tetratricopeptide repeat domain HNH_2 PF13391.6 EGD95663.1 - 5.6e-12 45.6 0.0 9.9e-12 44.8 0.0 1.4 1 0 0 1 1 1 1 HNH endonuclease Snf7 PF03357.21 EGD95665.1 - 2e-20 73.1 12.4 2e-20 73.1 12.4 1.9 1 1 1 2 2 2 1 Snf7 MerR-DNA-bind PF09278.11 EGD95665.1 - 0.71 10.4 11.9 2.2 8.9 1.1 3.7 4 0 0 4 4 4 0 MerR, DNA binding PDZ_5 PF17817.1 EGD95666.1 - 0.15 12.4 1.4 17 5.8 0.0 2.6 2 0 0 2 2 2 0 PDZ domain DFRP_C PF16543.5 EGD95667.1 - 1.5e-25 89.5 11.0 1.5e-25 89.5 11.0 3.5 3 1 0 3 3 3 1 DRG Family Regulatory Proteins, Tma46 Torus PF16131.5 EGD95667.1 - 4.9e-06 27.2 4.5 4.9e-06 27.2 4.5 4.1 2 2 2 4 4 4 2 Torus domain zf-CCCH_4 PF18044.1 EGD95667.1 - 5.8e-05 22.8 10.2 0.00087 19.0 2.7 3.3 3 0 0 3 3 3 1 CCCH-type zinc finger zf-CCCH PF00642.24 EGD95667.1 - 0.00033 20.5 1.3 0.00033 20.5 1.3 2.7 3 1 0 3 3 3 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 EGD95667.1 - 0.0012 18.8 6.7 0.0012 18.8 6.7 3.3 4 0 0 4 4 4 1 Zinc finger domain zf-CCCH_3 PF15663.5 EGD95667.1 - 0.1 12.8 6.2 0.58 10.4 0.9 2.7 1 1 0 2 2 2 0 Zinc-finger containing family zf-CCCH_2 PF14608.6 EGD95667.1 - 0.24 11.9 14.5 0.32 11.5 4.4 2.9 2 1 0 2 2 2 0 RNA-binding, Nab2-type zinc finger Ribosomal_L26 PF16906.5 EGD95669.1 - 2.8e-39 133.4 3.3 3.5e-39 133.1 3.3 1.1 1 0 0 1 1 1 1 Ribosomal proteins L26 eukaryotic, L24P archaeal KOW PF00467.29 EGD95669.1 - 9.7e-09 34.9 2.1 2e-08 33.9 2.1 1.6 1 0 0 1 1 1 1 KOW motif DUF1223 PF06764.11 EGD95669.1 - 0.011 15.7 0.1 0.013 15.6 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1223) Synaptobrevin PF00957.21 EGD95670.1 - 1e-31 108.5 0.0 1.4e-31 108.1 0.0 1.2 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.6 EGD95670.1 - 1.2e-29 102.2 0.1 1.7e-29 101.7 0.1 1.2 1 0 0 1 1 1 1 Regulated-SNARE-like domain Ion_trans PF00520.31 EGD95671.1 - 3e-08 33.2 27.6 4.6e-08 32.6 27.6 1.2 1 0 0 1 1 1 1 Ion transport protein GPR_Gpa2_C PF11970.8 EGD95672.1 - 0.09 12.9 0.1 0.99 9.5 0.0 2.4 2 0 0 2 2 2 0 G protein-coupled glucose receptor regulating Gpa2 C-term LrgB PF04172.16 EGD95672.1 - 1.2 8.7 9.6 0.096 12.2 3.0 2.4 1 1 1 2 2 2 0 LrgB-like family DUF2569 PF10754.9 EGD95672.1 - 5.1 7.5 12.6 0.21 12.0 2.6 2.8 1 1 0 2 2 2 0 Protein of unknown function (DUF2569) CPSase_L_D2 PF02786.17 EGD95673.1 - 3.3e-115 382.9 0.3 4.7e-84 281.1 0.0 2.3 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_sm_chain PF00988.22 EGD95673.1 - 2.3e-49 166.5 0.0 4.6e-49 165.5 0.0 1.5 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain GATase PF00117.28 EGD95673.1 - 6.2e-46 156.6 0.0 3.1e-45 154.3 0.0 2.2 2 0 0 2 2 2 1 Glutamine amidotransferase class-I OTCace_N PF02729.21 EGD95673.1 - 7.6e-46 155.8 0.1 1.7e-45 154.6 0.1 1.7 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain CPSase_L_D3 PF02787.19 EGD95673.1 - 1.1e-38 132.4 0.0 2.6e-38 131.1 0.0 1.7 1 0 0 1 1 1 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain OTCace PF00185.24 EGD95673.1 - 4.8e-32 111.2 0.0 1.4e-31 109.7 0.0 1.9 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain MGS PF02142.22 EGD95673.1 - 3.2e-22 78.5 0.0 1.4e-21 76.5 0.0 2.3 2 0 0 2 2 1 1 MGS-like domain Dala_Dala_lig_C PF07478.13 EGD95673.1 - 2.4e-18 66.4 0.7 7e-09 35.5 0.1 2.5 2 0 0 2 2 2 2 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 EGD95673.1 - 2.2e-16 59.9 0.1 8.9e-08 31.9 0.0 2.5 2 0 0 2 2 2 2 ATP-grasp domain ATPgrasp_Ter PF15632.6 EGD95673.1 - 3.1e-10 39.9 0.0 4.8e-05 23.1 0.0 2.9 3 0 0 3 3 3 2 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp_3 PF02655.14 EGD95673.1 - 4.7e-06 26.7 0.5 0.035 14.2 0.1 2.9 3 0 0 3 3 3 2 ATP-grasp domain Peptidase_C26 PF07722.13 EGD95673.1 - 9.1e-05 22.3 0.1 0.0068 16.2 0.1 2.7 1 1 0 1 1 1 1 Peptidase C26 DJ-1_PfpI PF01965.24 EGD95673.1 - 0.00036 20.4 0.0 0.35 10.6 0.0 3.9 4 0 0 4 4 4 1 DJ-1/PfpI family RimK PF08443.11 EGD95673.1 - 0.0017 18.0 0.0 1.6 8.3 0.0 2.7 2 0 0 2 2 2 2 RimK-like ATP-grasp domain GARS_A PF01071.19 EGD95673.1 - 0.0027 17.5 0.1 2.4 7.9 0.0 2.9 2 1 0 2 2 2 2 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain TrkA_N PF02254.18 EGD95673.1 - 0.074 13.3 0.1 0.68 10.2 0.0 2.5 2 0 0 2 2 2 0 TrkA-N domain ABC_tran PF00005.27 EGD95674.1 - 1.1e-19 71.3 0.0 1.1e-09 39.0 0.0 3.1 2 1 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 EGD95674.1 - 8.6e-05 22.5 3.9 0.063 13.1 0.0 2.8 2 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SbcCD_C PF13558.6 EGD95674.1 - 0.00049 20.3 0.0 0.055 13.7 0.0 2.7 2 0 0 2 2 2 1 Putative exonuclease SbcCD, C subunit DUF3584 PF12128.8 EGD95674.1 - 0.17 9.4 0.1 0.38 8.2 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) NB-ARC PF00931.22 EGD95674.1 - 0.19 10.9 0.1 1.8 7.7 0.0 2.1 2 0 0 2 2 2 0 NB-ARC domain Exo84_C PF16528.5 EGD95675.1 - 9.5e-69 231.3 0.1 9.5e-69 231.3 0.1 2.2 3 0 0 3 3 3 1 Exocyst component 84 C-terminal Vps51 PF08700.11 EGD95675.1 - 4.2e-16 58.8 1.9 4.2e-16 58.8 1.9 2.1 2 0 0 2 2 2 1 Vps51/Vps67 COG2 PF06148.11 EGD95675.1 - 0.0017 18.4 3.0 0.003 17.6 0.1 2.6 3 0 0 3 3 3 1 COG (conserved oligomeric Golgi) complex component, COG2 DUF2594 PF10769.9 EGD95675.1 - 0.022 14.8 0.1 0.049 13.7 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2594) DUF4088 PF13317.6 EGD95675.1 - 0.11 12.0 1.7 0.37 10.3 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4088) 7TMR-HDED PF07697.11 EGD95675.1 - 0.11 12.5 8.8 0.11 12.6 3.2 2.2 2 0 0 2 2 2 0 7TM-HD extracellular HIP1_clath_bdg PF16515.5 EGD95675.1 - 0.48 11.1 8.9 1.2 9.8 3.0 2.7 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF4407 PF14362.6 EGD95675.1 - 0.89 8.9 6.9 0.7 9.2 0.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Baculo_PEP_C PF04513.12 EGD95675.1 - 0.96 9.5 4.8 0.45 10.6 0.3 2.4 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus TPR_MLP1_2 PF07926.12 EGD95675.1 - 2.8 8.0 13.3 1.2 9.2 2.1 3.4 3 0 0 3 3 3 0 TPR/MLP1/MLP2-like protein MscS_porin PF12795.7 EGD95675.1 - 5 6.6 11.0 0.96 8.9 5.2 2.3 2 0 0 2 2 2 0 Mechanosensitive ion channel porin domain BST2 PF16716.5 EGD95675.1 - 6.1 7.5 6.8 17 6.1 1.3 2.7 2 0 0 2 2 2 0 Bone marrow stromal antigen 2 MAS20 PF02064.15 EGD95676.1 - 6.9e-44 149.1 0.3 8.1e-44 148.8 0.3 1.0 1 0 0 1 1 1 1 MAS20 protein import receptor Glyco_hydro_72 PF03198.14 EGD95677.1 - 2.8e-121 404.6 0.1 3.8e-121 404.2 0.1 1.1 1 0 0 1 1 1 1 Glucanosyltransferase Cellulase PF00150.18 EGD95677.1 - 2.6e-05 23.8 0.0 0.00061 19.3 0.0 2.1 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Ank_2 PF12796.7 EGD95678.1 - 2e-77 255.8 0.1 3.5e-16 59.6 0.5 7.8 4 3 3 7 7 7 7 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EGD95678.1 - 1.2e-57 191.6 0.0 3.5e-13 49.8 0.0 11.2 6 2 6 12 12 12 11 Ankyrin repeats (many copies) Ank_3 PF13606.6 EGD95678.1 - 3.1e-49 159.2 2.6 1.6e-05 24.9 0.0 15.8 18 0 0 18 18 16 8 Ankyrin repeat Ank PF00023.30 EGD95678.1 - 3.8e-43 144.1 7.0 1.1e-05 25.6 0.0 13.0 14 0 0 14 14 12 7 Ankyrin repeat Ank_5 PF13857.6 EGD95678.1 - 6.4e-39 131.5 5.9 9.3e-08 32.2 0.0 12.2 5 4 8 13 13 13 6 Ankyrin repeats (many copies) HeLo PF14479.6 EGD95678.1 - 4.9e-13 49.4 0.0 1.2e-10 41.5 0.0 2.5 1 1 0 1 1 1 1 Prion-inhibition and propagation NACHT PF05729.12 EGD95678.1 - 2.8e-06 27.3 0.0 6.1e-06 26.3 0.0 1.5 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 EGD95678.1 - 7.6e-05 23.0 0.0 0.00031 21.0 0.0 2.0 1 1 0 1 1 1 1 AAA domain NB-ARC PF00931.22 EGD95678.1 - 0.0013 18.0 0.1 0.012 14.8 0.1 2.1 1 1 0 1 1 1 1 NB-ARC domain AAA_16 PF13191.6 EGD95678.1 - 0.0016 18.8 0.0 0.0047 17.3 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain RNA_helicase PF00910.22 EGD95678.1 - 0.0033 17.8 0.0 0.0087 16.4 0.0 1.7 1 0 0 1 1 1 1 RNA helicase VWA_3_C PF18571.1 EGD95678.1 - 0.012 15.4 0.3 0.33 10.8 0.1 3.0 3 0 0 3 3 3 0 von Willebrand factor type A C-terminal domain ATPase_2 PF01637.18 EGD95678.1 - 0.026 14.5 0.0 0.05 13.5 0.0 1.5 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea GAF_3 PF13492.6 EGD95678.1 - 0.13 12.6 0.0 0.3 11.4 0.0 1.5 1 0 0 1 1 1 0 GAF domain ATP_bind_1 PF03029.17 EGD95678.1 - 0.14 11.9 0.0 0.28 10.9 0.0 1.5 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein RRM_1 PF00076.22 EGD95679.1 - 2.5e-06 27.2 0.0 0.00061 19.6 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FoP_duplication PF13865.6 EGD95679.1 - 7.3e-05 23.2 0.8 7.3e-05 23.2 0.8 2.7 2 1 0 2 2 2 1 C-terminal duplication domain of Friend of PRMT1 TetR_C_15 PF17918.1 EGD95685.1 - 0.27 12.0 4.0 0.66 10.8 4.0 1.6 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain Amino_oxidase PF01593.24 EGD95686.1 - 4.4e-70 237.2 0.0 6.3e-70 236.7 0.0 1.2 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EGD95686.1 - 1.1e-08 35.2 0.0 2.3e-08 34.2 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EGD95686.1 - 0.00016 21.0 0.1 0.0058 15.9 0.1 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EGD95686.1 - 0.00055 19.6 0.0 0.035 13.7 0.0 2.3 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 EGD95686.1 - 0.0079 15.5 0.1 0.27 10.4 0.0 2.3 2 0 0 2 2 2 1 FAD binding domain Pyr_redox PF00070.27 EGD95686.1 - 0.012 16.2 0.2 0.52 10.9 0.1 2.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EGD95686.1 - 0.05 12.9 0.2 0.18 11.0 0.1 1.9 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EGD95686.1 - 0.052 12.8 0.0 0.096 11.9 0.0 1.3 1 0 0 1 1 1 0 Thi4 family FAD_binding_2 PF00890.24 EGD95686.1 - 0.075 12.1 0.1 0.12 11.4 0.1 1.3 1 0 0 1 1 1 0 FAD binding domain AlaDh_PNT_C PF01262.21 EGD95686.1 - 0.098 11.9 0.9 0.19 11.0 0.1 1.9 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain adh_short PF00106.25 EGD95687.1 - 2.4e-22 79.3 0.0 3.2e-22 78.9 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EGD95687.1 - 2.7e-22 79.5 0.0 3.4e-22 79.2 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EGD95687.1 - 0.00018 21.5 0.0 0.00025 21.0 0.0 1.3 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 EGD95687.1 - 0.049 13.0 0.0 0.071 12.5 0.0 1.1 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) MlaE PF02405.16 EGD95687.1 - 0.058 13.1 0.1 0.13 11.9 0.0 1.5 2 0 0 2 2 2 0 Permease MlaE MFS_1 PF07690.16 EGD95688.1 - 1.2e-33 116.6 22.8 1.2e-33 116.6 22.8 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily Nucleo_P87 PF07267.11 EGD95690.1 - 8.8 5.0 10.1 14 4.4 10.1 1.3 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 Fungal_trans_2 PF11951.8 EGD95691.1 - 1.1e-48 166.0 0.2 8.1e-48 163.1 0.2 2.1 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EGD95691.1 - 0.00012 22.1 5.4 0.00024 21.1 5.4 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain ABC_tran PF00005.27 EGD95693.1 - 1.1e-47 161.9 0.3 6.3e-26 91.5 0.1 2.4 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 EGD95693.1 - 3.3e-28 99.1 37.3 2.5e-23 83.1 16.7 2.8 2 0 0 2 2 2 2 ABC transporter transmembrane region AAA_21 PF13304.6 EGD95693.1 - 2.1e-09 37.7 6.0 0.012 15.5 0.1 4.3 3 1 1 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EGD95693.1 - 6.2e-09 35.6 5.7 0.0024 17.3 0.1 4.1 4 0 0 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 EGD95693.1 - 9.3e-07 29.5 0.4 0.0011 19.5 0.0 2.5 2 0 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 EGD95693.1 - 1.8e-06 28.0 0.5 0.0014 18.5 0.0 2.4 2 0 0 2 2 2 1 RsgA GTPase AAA_29 PF13555.6 EGD95693.1 - 2e-06 27.5 0.7 0.011 15.4 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 EGD95693.1 - 1.8e-05 25.2 0.4 0.054 13.9 0.0 3.1 3 0 0 3 3 3 2 AAA ATPase domain MMR_HSR1 PF01926.23 EGD95693.1 - 7.1e-05 22.9 0.2 0.15 12.2 0.0 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_19 PF13245.6 EGD95693.1 - 0.00036 20.9 0.0 0.05 13.9 0.0 2.6 2 1 0 2 2 2 1 AAA domain AAA_24 PF13479.6 EGD95693.1 - 0.00038 20.2 0.1 5.6 6.6 0.0 3.3 3 0 0 3 3 3 0 AAA domain AAA PF00004.29 EGD95693.1 - 0.00043 20.7 0.5 0.11 13.0 0.0 3.6 2 2 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Dynamin_N PF00350.23 EGD95693.1 - 0.00086 19.4 0.1 0.036 14.1 0.0 2.5 2 0 0 2 2 2 1 Dynamin family AAA_22 PF13401.6 EGD95693.1 - 0.0012 19.1 3.8 0.28 11.5 0.4 3.0 3 0 0 3 3 2 1 AAA domain AAA_15 PF13175.6 EGD95693.1 - 0.0027 17.5 1.0 0.041 13.6 0.1 2.2 2 0 0 2 2 2 1 AAA ATPase domain Viral_helicase1 PF01443.18 EGD95693.1 - 0.0039 17.0 0.8 0.3 10.8 0.0 2.5 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase NB-ARC PF00931.22 EGD95693.1 - 0.006 15.8 1.0 0.82 8.8 0.5 2.7 2 1 0 2 2 2 1 NB-ARC domain ATPase_2 PF01637.18 EGD95693.1 - 0.0069 16.3 0.1 0.48 10.3 0.0 2.8 3 0 0 3 3 3 1 ATPase domain predominantly from Archaea DUF815 PF05673.13 EGD95693.1 - 0.011 14.9 0.2 1 8.5 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA_7 PF12775.7 EGD95693.1 - 0.013 15.0 0.3 1.5 8.3 0.0 2.5 2 0 0 2 2 2 0 P-loop containing dynein motor region T2SSE PF00437.20 EGD95693.1 - 0.016 14.2 0.5 0.22 10.6 0.0 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein RNA_helicase PF00910.22 EGD95693.1 - 0.018 15.4 0.2 2.3 8.6 0.0 2.9 3 0 0 3 3 2 0 RNA helicase AAA_30 PF13604.6 EGD95693.1 - 0.02 14.7 0.1 2.6 7.7 0.0 2.8 2 1 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 EGD95693.1 - 0.022 14.5 4.2 13 5.5 0.0 4.2 4 0 0 4 4 4 0 IstB-like ATP binding protein MeaB PF03308.16 EGD95693.1 - 0.044 12.8 0.9 1.2 8.0 0.1 2.4 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_10 PF12846.7 EGD95693.1 - 0.049 12.5 1.0 4.6 6.1 0.1 2.5 2 1 0 2 2 2 0 AAA-like domain Adeno_IVa2 PF02456.15 EGD95693.1 - 0.057 12.2 0.2 0.21 10.4 0.0 1.9 2 0 0 2 2 2 0 Adenovirus IVa2 protein Zeta_toxin PF06414.12 EGD95693.1 - 0.062 12.6 0.1 4.1 6.6 0.0 2.4 2 0 0 2 2 2 0 Zeta toxin NTPase_1 PF03266.15 EGD95693.1 - 0.088 12.7 2.8 7 6.5 0.1 2.6 2 0 0 2 2 2 0 NTPase AAA_14 PF13173.6 EGD95693.1 - 0.097 12.7 0.2 0.66 10.0 0.0 2.5 3 0 0 3 3 2 0 AAA domain ABC_ATPase PF09818.9 EGD95693.1 - 0.16 10.7 3.1 1.4 7.6 0.1 3.0 3 1 0 3 3 3 0 Predicted ATPase of the ABC class AAA_18 PF13238.6 EGD95693.1 - 0.16 12.5 0.1 8.5 6.9 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 EGD95693.1 - 0.22 11.1 0.4 2.2 7.8 0.1 2.3 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 EGD95693.1 - 0.23 11.4 3.4 0.96 9.3 0.0 3.1 3 0 0 3 3 2 0 NACHT domain Roc PF08477.13 EGD95693.1 - 0.24 11.6 0.4 64 3.8 0.0 3.2 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase cobW PF02492.19 EGD95693.1 - 0.45 10.1 7.1 0.38 10.3 0.8 2.7 3 0 0 3 3 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_33 PF13671.6 EGD95693.1 - 0.49 10.5 1.4 7.5 6.7 0.1 3.1 3 0 0 3 3 2 0 AAA domain DUF87 PF01935.17 EGD95693.1 - 0.84 9.7 3.8 1.9 8.5 0.5 2.4 2 0 0 2 2 2 0 Helicase HerA, central domain Rad17 PF03215.15 EGD95693.1 - 1.9 8.3 5.4 1 9.3 0.3 2.7 3 0 0 3 3 3 0 Rad17 P-loop domain Condensation PF00668.20 EGD95695.1 - 0 1309.3 0.0 1.2e-55 189.0 0.0 11.1 10 3 0 10 10 10 10 Condensation domain AMP-binding PF00501.28 EGD95695.1 - 0 1304.0 0.0 2e-82 277.1 0.0 5.2 5 0 0 5 5 5 5 AMP-binding enzyme PP-binding PF00550.25 EGD95695.1 - 5.4e-74 244.5 6.7 3.3e-11 43.4 0.3 7.8 7 0 0 7 7 7 7 Phosphopantetheine attachment site AMP-binding_C PF13193.6 EGD95695.1 - 7.6e-14 52.4 0.2 0.00089 20.2 0.0 5.8 5 0 0 5 5 5 2 AMP-binding enzyme C-terminal domain Transferase PF02458.15 EGD95695.1 - 7.5e-12 44.6 0.2 0.0014 17.4 0.0 5.9 7 0 0 7 7 7 4 Transferase family DUF5122 PF17164.4 EGD95695.1 - 0.35 11.2 1.5 21 5.5 0.1 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF5122) beta-propeller GMP_synt_C PF00958.22 EGD95697.1 - 2.6e-42 142.8 0.0 5.1e-42 141.9 0.0 1.5 1 0 0 1 1 1 1 GMP synthase C terminal domain GATase PF00117.28 EGD95697.1 - 1.3e-38 132.7 0.0 2.2e-38 131.9 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase class-I NAD_synthase PF02540.17 EGD95697.1 - 1.7e-10 40.4 0.1 2.6e-06 26.7 0.1 2.3 2 0 0 2 2 2 2 NAD synthase Peptidase_C26 PF07722.13 EGD95697.1 - 3.6e-07 30.2 0.1 6.3e-07 29.4 0.1 1.4 1 0 0 1 1 1 1 Peptidase C26 QueC PF06508.13 EGD95697.1 - 0.0011 18.5 0.0 0.0084 15.6 0.0 2.0 1 1 0 1 1 1 1 Queuosine biosynthesis protein QueC tRNA_Me_trans PF03054.16 EGD95697.1 - 0.0029 16.4 0.1 0.007 15.2 0.1 1.6 2 0 0 2 2 2 1 tRNA methyl transferase ThiI PF02568.14 EGD95697.1 - 0.0074 15.9 0.1 0.017 14.7 0.1 1.5 2 0 0 2 2 2 1 Thiamine biosynthesis protein (ThiI) Arginosuc_synth PF00764.19 EGD95697.1 - 0.011 15.1 0.1 0.017 14.4 0.1 1.3 1 0 0 1 1 1 0 Arginosuccinate synthase PAPS_reduct PF01507.19 EGD95697.1 - 0.059 13.4 0.0 0.093 12.8 0.0 1.3 1 0 0 1 1 1 0 Phosphoadenosine phosphosulfate reductase family ATP_bind_3 PF01171.20 EGD95697.1 - 0.098 12.4 0.0 0.15 11.8 0.0 1.3 1 0 0 1 1 1 0 PP-loop family BCIP PF13862.6 EGD95698.1 - 3.7e-74 249.0 0.1 4.7e-74 248.6 0.1 1.1 1 0 0 1 1 1 1 p21-C-terminal region-binding protein VID27_N PF17748.1 EGD95698.1 - 0.069 13.0 0.5 0.12 12.2 0.5 1.4 1 0 0 1 1 1 0 VID27 N-terminal region WD40 PF00400.32 EGD95700.1 - 2e-28 98.0 11.1 6.9e-07 29.9 0.5 6.7 7 0 0 7 7 7 5 WD domain, G-beta repeat Nup160 PF11715.8 EGD95700.1 - 1.6e-06 27.0 2.3 0.094 11.3 0.1 4.9 4 1 1 5 5 5 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 EGD95700.1 - 2.7e-05 24.4 0.0 0.16 12.3 0.0 4.4 3 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain CENP-F_leu_zip PF10473.9 EGD95700.1 - 0.0081 16.2 3.1 0.014 15.4 3.1 1.3 1 0 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Seryl_tRNA_N PF02403.22 EGD95700.1 - 0.015 15.5 0.5 0.031 14.5 0.5 1.4 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain APG6_N PF17675.1 EGD95700.1 - 0.025 15.1 1.8 0.054 14.0 1.8 1.6 1 1 0 1 1 1 0 Apg6 coiled-coil region DUF3450 PF11932.8 EGD95700.1 - 0.037 13.3 0.7 0.068 12.5 0.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) EzrA PF06160.12 EGD95700.1 - 0.041 12.1 0.2 0.06 11.5 0.2 1.2 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA RasGAP_C PF03836.15 EGD95700.1 - 0.073 13.2 0.0 0.53 10.4 0.0 2.1 2 0 0 2 2 2 0 RasGAP C-terminus BBS2_Mid PF14783.6 EGD95700.1 - 0.078 13.0 0.1 1.3 9.1 0.0 3.1 6 0 0 6 6 6 0 Ciliary BBSome complex subunit 2, middle region DUF5046 PF16465.5 EGD95700.1 - 0.14 11.6 0.2 0.79 9.1 0.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF5046) PI3K_P85_iSH2 PF16454.5 EGD95700.1 - 0.16 11.6 1.4 0.36 10.4 1.3 1.5 1 1 0 1 1 1 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain DUF1664 PF07889.12 EGD95700.1 - 0.25 11.4 2.7 1 9.4 0.4 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) DUF4164 PF13747.6 EGD95700.1 - 0.72 10.2 4.8 9 6.7 0.1 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4164) Sad1_UNC PF07738.13 EGD95701.1 - 3.5e-13 49.7 0.0 1.4e-11 44.5 0.0 2.4 1 1 0 1 1 1 1 Sad1 / UNC-like C-terminal Suf PF05843.14 EGD95701.1 - 4.1 7.3 14.4 5.6 6.9 3.0 2.5 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) DUF3439 PF11921.8 EGD95701.1 - 6.9 6.7 10.9 0.22 11.5 3.9 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) Spt20 PF12090.8 EGD95701.1 - 7.4 6.1 23.8 1.3 8.6 3.6 2.4 2 0 0 2 2 2 0 Spt20 family Kinesin PF00225.23 EGD95702.1 - 3.3e-89 299.1 3.8 1.3e-88 297.2 0.0 3.1 3 0 0 3 3 3 1 Kinesin motor domain Microtub_bd PF16796.5 EGD95702.1 - 2e-17 63.5 0.0 8e-14 51.8 0.0 3.5 3 0 0 3 3 3 2 Microtubule binding SHE3 PF17078.5 EGD95702.1 - 0.0029 17.4 19.5 0.0029 17.4 19.5 8.8 5 2 3 9 9 9 2 SWI5-dependent HO expression protein 3 Glycos_transf_1 PF00534.20 EGD95703.1 - 6.4e-31 107.2 0.0 5.1e-29 101.0 0.0 2.3 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 EGD95703.1 - 2e-19 70.2 0.2 4.3e-19 69.1 0.2 1.6 1 1 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_1_4 PF13692.6 EGD95703.1 - 1.3e-13 51.6 0.0 8.4e-13 48.9 0.0 2.3 1 1 1 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 EGD95703.1 - 5.5e-09 36.7 0.5 9.5e-09 35.9 0.5 1.4 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_trans_1_2 PF13524.6 EGD95703.1 - 0.00011 22.5 0.0 0.00025 21.4 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferases group 1 ALG11_N PF15924.5 EGD95703.1 - 0.025 14.6 0.0 5.9 6.9 0.0 2.4 2 0 0 2 2 2 0 ALG11 mannosyltransferase N-terminus Peptidase_M19 PF01244.21 EGD95704.1 - 1.1e-107 359.9 0.0 1.3e-107 359.7 0.0 1.0 1 0 0 1 1 1 1 Membrane dipeptidase (Peptidase family M19) GST_C PF00043.25 EGD95707.1 - 2.9e-15 56.3 0.0 5.9e-15 55.3 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EGD95707.1 - 2.2e-10 40.8 0.0 4.7e-10 39.7 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 EGD95707.1 - 5.5e-10 39.4 0.0 1.1e-09 38.5 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EGD95707.1 - 1.8e-09 37.8 0.0 3.6e-09 36.8 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EGD95707.1 - 3.5e-09 36.8 0.0 6.2e-09 36.0 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EGD95707.1 - 4.4e-08 33.0 0.0 8.4e-08 32.1 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Aldedh PF00171.22 EGD95708.1 - 3.8e-144 480.6 1.4 5.6e-87 292.2 0.1 2.0 1 1 1 2 2 2 2 Aldehyde dehydrogenase family DUF1487 PF07368.11 EGD95708.1 - 0.1 12.1 0.0 11 5.4 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1487) Metallophos PF00149.28 EGD95709.1 - 6.2e-32 111.8 0.0 1.4e-27 97.5 0.0 2.1 2 0 0 2 2 2 2 Calcineurin-like phosphoesterase Glyco_hydro_65N PF03636.15 EGD95709.1 - 0.0023 17.6 0.0 0.0035 17.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 65, N-terminal domain DIOX_N PF14226.6 EGD95710.1 - 1.7e-09 38.4 0.0 3.6e-09 37.4 0.0 1.5 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EGD95710.1 - 1.1e-06 29.0 0.0 6.1e-05 23.4 0.0 2.3 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Ctr PF04145.15 EGD95711.1 - 9.7e-41 139.8 0.1 1.2e-40 139.5 0.1 1.1 1 0 0 1 1 1 1 Ctr copper transporter family TraL PF07178.11 EGD95711.1 - 0.48 10.9 2.9 15 6.1 0.3 2.2 2 0 0 2 2 2 0 TraL protein RRM_1 PF00076.22 EGD95712.1 - 1.8e-08 34.0 0.0 4.9e-08 32.7 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-C2H2 PF00096.26 EGD95714.1 - 1.4e-11 44.2 11.8 4.8e-06 26.7 0.6 2.9 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EGD95714.1 - 4.7e-08 33.2 9.3 0.00038 21.1 0.6 3.1 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EGD95714.1 - 5.2e-07 29.8 8.4 2.1e-05 24.7 2.3 3.1 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_jaz PF12171.8 EGD95714.1 - 0.00071 19.8 8.6 0.014 15.7 0.1 3.0 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 EGD95714.1 - 0.0014 18.6 5.6 0.52 10.4 0.8 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_5 PF13909.6 EGD95714.1 - 0.0072 16.1 0.2 0.0072 16.1 0.2 3.4 3 0 0 3 3 3 1 C2H2-type zinc-finger domain zf-C2HE PF16278.5 EGD95714.1 - 0.046 14.2 8.5 1.1 9.8 0.9 2.7 1 1 1 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger zf-met PF12874.7 EGD95714.1 - 0.05 14.0 11.8 0.4 11.1 0.2 3.2 3 0 0 3 3 2 0 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.5 EGD95714.1 - 0.33 10.7 3.2 5.7 6.8 0.2 2.5 2 0 0 2 2 2 0 zinc-finger C2H2-type zf-BED PF02892.15 EGD95714.1 - 0.64 10.1 4.3 0.38 10.8 0.5 2.2 2 0 0 2 2 2 0 BED zinc finger BolA PF01722.18 EGD95714.1 - 4.3 7.7 6.6 1.1 9.6 0.1 2.7 2 1 1 3 3 3 0 BolA-like protein p450 PF00067.22 EGD95716.1 - 3.9e-62 210.5 0.0 4.7e-62 210.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DivIC PF04977.15 EGD95717.1 - 0.029 14.1 0.1 0.029 14.1 0.1 2.0 3 0 0 3 3 3 0 Septum formation initiator GATA PF00320.27 EGD95718.1 - 5.2e-15 54.7 1.3 1.1e-14 53.7 1.3 1.6 1 0 0 1 1 1 1 GATA zinc finger SUIM_assoc PF16619.5 EGD95718.1 - 0.00068 19.7 3.1 0.00068 19.7 3.1 2.9 3 0 0 3 3 3 1 Unstructured region C-term to UIM in Ataxin3 TF_Zn_Ribbon PF08271.12 EGD95718.1 - 0.1 12.1 0.2 0.22 11.0 0.2 1.5 1 0 0 1 1 1 0 TFIIB zinc-binding Auto_anti-p27 PF06677.12 EGD95718.1 - 0.23 11.6 0.2 0.4 10.9 0.2 1.4 1 0 0 1 1 1 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) Metallophos PF00149.28 EGD95721.1 - 2.3e-10 41.3 0.4 3.4e-10 40.8 0.4 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EGD95721.1 - 1.5e-05 25.3 0.0 0.00019 21.7 0.0 2.1 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Phage_Mu_Gam PF07352.12 EGD95721.1 - 0.14 12.0 0.1 0.24 11.3 0.1 1.3 1 0 0 1 1 1 0 Bacteriophage Mu Gam like protein Ribosomal_S8 PF00410.19 EGD95722.1 - 8.6e-22 77.4 0.2 1.3e-21 76.8 0.2 1.3 1 1 0 1 1 1 1 Ribosomal protein S8 His_Phos_1 PF00300.22 EGD95723.1 - 1.8e-13 50.6 0.0 6.3e-13 48.8 0.0 1.8 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) ubiquitin PF00240.23 EGD95724.1 - 7.2e-06 25.7 0.0 1.5e-05 24.6 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family DUF2407 PF10302.9 EGD95724.1 - 0.00045 20.7 0.1 0.0016 19.0 0.0 2.0 2 0 0 2 2 2 1 DUF2407 ubiquitin-like domain PS_Dcarbxylase PF02666.15 EGD95725.1 - 1.8e-75 252.9 0.0 6.6e-75 251.0 0.0 1.8 1 1 0 1 1 1 1 Phosphatidylserine decarboxylase E1-E2_ATPase PF00122.20 EGD95726.1 - 6.7e-37 126.8 17.1 8.3e-31 106.9 0.1 3.7 4 0 0 4 4 4 2 E1-E2 ATPase Cation_ATPase_C PF00689.21 EGD95726.1 - 9.1e-26 90.7 7.2 9.1e-26 90.7 7.2 2.8 3 0 0 3 3 3 2 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 EGD95726.1 - 1.1e-18 68.3 0.0 1.8e-14 54.5 0.0 3.1 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EGD95726.1 - 9e-17 60.5 0.0 1.9e-16 59.5 0.0 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Cation_ATPase PF13246.6 EGD95726.1 - 1.5e-15 57.0 0.0 3.3e-15 55.9 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 EGD95726.1 - 0.00013 21.8 0.4 0.0026 17.5 0.6 2.2 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase DUF2463 PF09591.10 EGD95726.1 - 0.0037 17.2 0.6 0.0082 16.0 0.6 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2463) Wzy_C PF04932.15 EGD95726.1 - 0.34 10.5 0.0 0.34 10.5 0.0 2.6 3 0 0 3 3 3 0 O-Antigen ligase ANAPC10 PF03256.16 EGD95727.1 - 1.9e-45 154.8 0.0 2.9e-45 154.2 0.0 1.2 1 0 0 1 1 1 1 Anaphase-promoting complex, subunit 10 (APC10) BUD22 PF09073.10 EGD95727.1 - 0.078 12.3 24.0 0.019 14.3 11.4 2.1 2 0 0 2 2 2 0 BUD22 DNA_pol_phi PF04931.13 EGD95727.1 - 1.3 7.1 39.2 0.15 10.1 24.2 2.0 2 0 0 2 2 2 0 DNA polymerase phi Cwf_Cwc_15 PF04889.12 EGD95727.1 - 3.7 7.2 32.2 0.95 9.2 6.5 2.2 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein CPSF100_C PF13299.6 EGD95727.1 - 6.2 7.0 8.6 5.4 7.2 4.6 2.1 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal FYDLN_acid PF09538.10 EGD95727.1 - 6.2 7.5 28.4 2.7 8.7 5.3 2.6 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) Iso_dh PF00180.20 EGD95728.1 - 5.1e-128 427.1 0.0 5.8e-128 426.9 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase AAA_lid_3 PF17862.1 EGD95728.1 - 0.043 13.6 0.0 0.12 12.2 0.0 1.7 1 0 0 1 1 1 0 AAA+ lid domain Methyltransf_23 PF13489.6 EGD95730.1 - 2.2e-20 73.1 0.0 3.6e-20 72.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EGD95730.1 - 8.4e-10 39.2 0.0 2.1e-09 37.9 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EGD95730.1 - 9.1e-09 35.3 0.0 7.8e-08 32.2 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EGD95730.1 - 4.7e-07 30.4 0.0 1.1e-06 29.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EGD95730.1 - 9.7e-06 26.3 0.0 7.1e-05 23.5 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EGD95730.1 - 0.0019 17.7 0.0 0.0041 16.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain FtsJ PF01728.19 EGD95730.1 - 0.0089 16.2 0.0 0.016 15.3 0.0 1.4 1 1 0 1 1 1 1 FtsJ-like methyltransferase Sterol_MT_C PF08498.10 EGD95730.1 - 0.014 15.7 0.0 0.063 13.6 0.0 2.1 1 1 0 1 1 1 0 Sterol methyltransferase C-terminal Methyltransf_16 PF10294.9 EGD95730.1 - 0.036 13.8 0.0 0.059 13.1 0.0 1.3 1 0 0 1 1 1 0 Lysine methyltransferase Methyltransf_4 PF02390.17 EGD95730.1 - 0.039 13.4 0.0 0.095 12.2 0.0 1.6 2 0 0 2 2 2 0 Putative methyltransferase PrmA PF06325.13 EGD95730.1 - 0.1 12.0 0.0 0.18 11.2 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) CDP-OH_P_transf PF01066.21 EGD95731.1 - 1.8e-12 47.8 0.3 1.8e-12 47.8 0.3 2.0 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase PP2C PF00481.21 EGD95732.1 - 9.9e-32 110.6 0.0 9.1e-26 91.0 0.0 2.2 2 0 0 2 2 2 2 Protein phosphatase 2C PP2C_2 PF13672.6 EGD95732.1 - 0.0052 16.4 0.0 0.018 14.7 0.0 1.9 2 0 0 2 2 2 1 Protein phosphatase 2C Rap1a PF18602.1 EGD95733.1 - 0.11 12.9 0.8 0.22 11.8 0.8 1.5 1 0 0 1 1 1 0 Rap1a immunity proteins DUF5423 PF17461.2 EGD95733.1 - 0.64 8.8 10.5 0.89 8.3 10.5 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5423) ATG16 PF08614.11 EGD95734.1 - 0.015 15.5 1.9 0.026 14.8 1.9 1.3 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) GrpE PF01025.19 EGD95734.1 - 0.41 10.3 4.3 4.5 6.9 2.0 2.8 2 1 1 3 3 3 0 GrpE ABC_tran_CTD PF16326.5 EGD95734.1 - 1.4 9.2 6.3 44 4.4 6.7 2.3 1 1 1 2 2 2 0 ABC transporter C-terminal domain PKcGMP_CC PF16808.5 EGD95734.1 - 2.3 8.2 5.9 5.2 7.0 1.1 3.0 3 0 0 3 3 3 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Serglycin PF04360.12 EGD95734.1 - 8.7 6.3 12.8 0.084 12.8 2.6 2.4 2 0 0 2 2 2 0 Serglycin RRM_1 PF00076.22 EGD95735.1 - 1.3e-40 137.1 0.4 1.7e-18 66.2 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RBM39linker PF15519.6 EGD95735.1 - 2.7e-26 92.5 0.5 5.4e-24 85.1 0.2 3.0 3 0 0 3 3 3 1 linker between RRM2 and RRM3 domains in RBM39 protein RRM_occluded PF16842.5 EGD95735.1 - 0.00083 19.2 0.0 1 9.2 0.0 2.7 3 0 0 3 3 3 2 Occluded RNA-recognition motif RRM_3 PF08777.11 EGD95735.1 - 0.061 13.4 0.0 0.28 11.3 0.0 2.1 2 0 0 2 2 2 0 RNA binding motif RRM_7 PF16367.5 EGD95735.1 - 0.068 13.3 0.0 1.4 9.1 0.0 2.4 2 0 0 2 2 2 0 RNA recognition motif PHM7_cyt PF14703.6 EGD95735.1 - 0.072 13.3 0.1 5.6 7.2 0.1 2.7 1 1 0 1 1 1 0 Cytosolic domain of 10TM putative phosphate transporter MFS_1 PF07690.16 EGD95736.1 - 1.5e-36 126.1 42.5 2.1e-35 122.3 41.4 2.6 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EGD95736.1 - 4.4e-11 42.3 12.1 4.4e-11 42.3 12.1 3.0 3 0 0 3 3 3 2 Sugar (and other) transporter Ac76 PF05814.11 EGD95736.1 - 0.0019 18.1 1.1 0.5 10.4 0.2 2.6 2 0 0 2 2 2 2 Orf76 (Ac76) OATP PF03137.20 EGD95736.1 - 0.0067 14.8 2.1 0.0067 14.8 2.1 2.9 3 0 0 3 3 3 2 Organic Anion Transporter Polypeptide (OATP) family DUF2721 PF11026.8 EGD95736.1 - 0.025 14.5 0.2 0.025 14.5 0.2 3.8 4 0 0 4 4 4 0 Protein of unknown function (DUF2721) DUF2561 PF10812.8 EGD95736.1 - 0.036 14.1 4.9 0.04 14.0 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2561) Cyt-b5 PF00173.28 EGD95738.1 - 2.1e-18 66.2 0.1 2.1e-18 66.2 0.1 1.9 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain FA_hydroxylase PF04116.13 EGD95738.1 - 1.5e-12 48.0 15.6 1.5e-12 48.0 15.6 1.8 3 0 0 3 3 3 1 Fatty acid hydroxylase superfamily Anth_synt_I_N PF04715.13 EGD95738.1 - 0.0069 16.6 0.4 0.014 15.6 0.4 1.5 1 0 0 1 1 1 1 Anthranilate synthase component I, N terminal region OMPdecase PF00215.24 EGD95740.1 - 1.6e-08 34.5 0.0 1.3e-06 28.2 0.0 2.4 2 1 0 2 2 2 2 Orotidine 5'-phosphate decarboxylase / HUMPS family Cu-oxidase_2 PF07731.14 EGD95741.1 - 4.1e-49 165.8 8.4 8.1e-43 145.4 0.4 3.5 3 1 0 3 3 3 3 Multicopper oxidase Cu-oxidase_3 PF07732.15 EGD95741.1 - 9.3e-42 141.8 1.9 1.8e-38 131.2 0.3 3.2 3 0 0 3 3 3 2 Multicopper oxidase Cu-oxidase PF00394.22 EGD95741.1 - 2.5e-37 128.4 1.1 3.8e-33 114.9 0.3 3.1 3 0 0 3 3 3 2 Multicopper oxidase Cupredoxin_1 PF13473.6 EGD95741.1 - 0.00068 19.7 0.0 4.2 7.5 0.0 3.5 2 1 0 2 2 2 2 Cupredoxin-like domain FTR1 PF03239.14 EGD95742.1 - 8.2e-82 274.8 11.9 1e-81 274.5 11.9 1.0 1 0 0 1 1 1 1 Iron permease FTR1 family FtsX PF02687.21 EGD95742.1 - 0.07 13.6 1.0 0.07 13.6 1.0 3.8 2 1 0 2 2 2 0 FtsX-like permease family Rft-1 PF04506.13 EGD95742.1 - 0.25 10.0 4.5 0.037 12.8 0.7 1.5 2 0 0 2 2 2 0 Rft protein Adap_comp_sub PF00928.21 EGD95744.1 - 6.9e-21 74.8 0.0 9.7e-21 74.3 0.0 1.2 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 EGD95744.1 - 5.4e-08 32.9 0.1 8.7e-08 32.2 0.1 1.3 1 0 0 1 1 1 1 Clathrin adaptor complex small chain RPM2 PF08579.11 EGD95744.1 - 0.0024 18.3 0.2 0.0045 17.4 0.2 1.4 1 0 0 1 1 1 1 Mitochondrial ribonuclease P subunit (RPM2) DUF2420 PF10336.9 EGD95745.1 - 3.3e-18 65.7 0.0 5.6e-18 64.9 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2420) Mg_trans_NIPA PF05653.14 EGD95748.1 - 7.8e-105 350.2 15.0 9.1e-105 350.0 15.0 1.0 1 0 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.20 EGD95748.1 - 1.2e-06 28.8 31.7 4e-05 23.8 8.0 3.3 3 0 0 3 3 3 3 EamA-like transporter family Acyl_transf_3 PF01757.22 EGD95748.1 - 0.0026 16.9 7.2 0.0026 16.9 7.2 2.2 1 1 1 2 2 2 2 Acyltransferase family Syja_N PF02383.18 EGD95749.1 - 4.4e-92 308.8 0.0 7.1e-92 308.1 0.0 1.3 1 0 0 1 1 1 1 SacI homology domain hSac2 PF12456.8 EGD95749.1 - 5.5e-38 129.2 0.0 9.7e-38 128.4 0.0 1.4 1 0 0 1 1 1 1 Inositol phosphatase HEAT_EZ PF13513.6 EGD95750.1 - 3.5e-30 104.0 12.6 1.4e-15 57.4 0.0 10.1 7 3 4 11 11 11 5 HEAT-like repeat HEAT PF02985.22 EGD95750.1 - 1.9e-22 77.4 18.3 7.5e-05 22.7 0.0 11.6 14 0 0 14 14 13 3 HEAT repeat HEAT_2 PF13646.6 EGD95750.1 - 4.8e-18 65.3 2.2 1.8e-05 25.0 0.0 8.1 5 3 3 8 8 8 3 HEAT repeats Cnd1 PF12717.7 EGD95750.1 - 1.3e-11 44.8 0.0 0.0042 17.1 0.0 5.9 4 2 2 6 6 6 2 non-SMC mitotic condensation complex subunit 1 MMS19_C PF12460.8 EGD95750.1 - 1.6e-08 34.1 5.9 0.42 9.7 0.3 5.4 5 1 0 5 5 5 3 RNAPII transcription regulator C-terminal Vac14_Fab1_bd PF12755.7 EGD95750.1 - 5.2e-08 33.4 0.0 0.074 13.6 0.0 4.5 4 1 0 4 4 4 2 Vacuolar 14 Fab1-binding region CLASP_N PF12348.8 EGD95750.1 - 8.7e-08 32.0 0.4 0.0045 16.6 0.2 5.7 3 3 2 5 5 5 1 CLASP N terminal Xpo1 PF08389.12 EGD95750.1 - 2e-05 24.7 0.1 0.00048 20.2 0.0 3.4 4 1 0 4 4 1 1 Exportin 1-like protein RIX1 PF08167.12 EGD95750.1 - 5.1e-05 23.1 0.8 3.1 7.5 0.0 5.5 5 1 1 6 6 6 1 rRNA processing/ribosome biogenesis IBN_N PF03810.19 EGD95750.1 - 7.8e-05 22.5 0.8 0.012 15.5 0.0 4.2 3 2 1 4 4 4 1 Importin-beta N-terminal domain Sec7_N PF12783.7 EGD95750.1 - 0.00031 20.7 0.3 0.0099 15.8 0.1 2.7 2 0 0 2 2 2 1 Guanine nucleotide exchange factor in Golgi transport N-terminal Adaptin_N PF01602.20 EGD95750.1 - 0.00047 18.8 0.1 0.16 10.5 0.0 3.8 2 2 1 3 3 3 1 Adaptin N terminal region DUF3437 PF11919.8 EGD95750.1 - 0.00062 19.6 0.7 0.16 11.9 0.0 4.6 6 0 0 6 6 5 1 Domain of unknown function (DUF3437) Dopey_N PF04118.14 EGD95750.1 - 0.00077 18.7 0.0 0.06 12.4 0.0 2.5 2 0 0 2 2 2 1 Dopey, N-terminal Arm PF00514.23 EGD95750.1 - 0.0027 17.7 6.7 2.1 8.5 0.0 6.1 7 0 0 7 7 6 1 Armadillo/beta-catenin-like repeat RTP1_C1 PF10363.9 EGD95750.1 - 0.0045 17.1 0.0 0.03 14.5 0.0 2.5 2 0 0 2 2 1 1 Required for nuclear transport of RNA pol II C-terminus 1 DNA_alkylation PF08713.11 EGD95750.1 - 0.085 12.6 0.0 2.4 7.8 0.0 2.7 3 0 0 3 3 3 0 DNA alkylation repair enzyme HEAT_PBS PF03130.16 EGD95750.1 - 0.19 12.5 4.5 27 5.8 0.0 5.3 7 0 0 7 7 3 0 PBS lyase HEAT-like repeat TAFH PF07531.14 EGD95750.1 - 0.93 9.6 7.0 29 4.8 0.0 5.3 6 0 0 6 6 5 0 NHR1 homology to TAF DUF2846 PF11008.8 EGD95751.1 - 0.02 14.9 0.0 0.028 14.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2846) Fungal_trans_2 PF11951.8 EGD95753.1 - 2.3e-09 36.6 1.2 3.8e-09 35.8 1.2 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EGD95753.1 - 3.8e-07 30.1 15.5 7.1e-07 29.2 15.5 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Peptidase_C12 PF01088.21 EGD95754.1 - 3.7e-68 229.4 0.0 5.4e-68 228.9 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 UCH_C PF18031.1 EGD95754.1 - 6.6e-08 32.3 0.0 1.6e-07 31.1 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolases GP120 PF00516.18 EGD95755.1 - 0.095 11.3 0.0 0.12 11.0 0.0 1.1 1 0 0 1 1 1 0 Envelope glycoprotein GP120 RT_RNaseH_2 PF17919.1 EGD95758.1 - 0.00014 21.9 0.2 0.0002 21.4 0.2 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 EGD95758.1 - 0.00019 21.7 0.2 0.00024 21.4 0.2 1.4 1 1 0 1 1 1 1 RNase H-like domain found in reverse transcriptase ThiS-like PF14453.6 EGD95758.1 - 0.009 16.0 0.3 0.017 15.2 0.1 1.5 2 0 0 2 2 2 1 ThiS-like ubiquitin MFS_1 PF07690.16 EGD95759.1 - 6e-27 94.5 33.4 9.4e-27 93.9 33.1 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily Neurensin PF14927.6 EGD95759.1 - 2.7 7.7 9.4 2.4 7.8 0.3 3.2 3 1 0 3 3 3 0 Neurensin Amidohydro_2 PF04909.14 EGD95760.1 - 5.9e-19 68.9 0.0 7e-19 68.7 0.0 1.1 1 0 0 1 1 1 1 Amidohydrolase Fungal_trans PF04082.18 EGD95761.1 - 9.8e-26 90.4 0.1 1.5e-25 89.7 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EGD95761.1 - 1.9e-10 40.6 7.7 3.4e-10 39.9 7.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SOGA PF11365.8 EGD95761.1 - 0.14 13.3 0.9 0.42 11.8 0.9 1.7 2 0 0 2 2 2 0 Protein SOGA Sugarporin_N PF11471.8 EGD95761.1 - 0.16 11.9 0.0 0.43 10.6 0.0 1.7 1 0 0 1 1 1 0 Maltoporin periplasmic N-terminal extension Spc24 PF08286.11 EGD95761.1 - 1.8 8.8 4.0 8.5 6.7 0.0 2.7 2 1 0 2 2 2 0 Spc24 subunit of Ndc80 Opy2 PF09463.10 EGD95761.1 - 2.3 8.6 8.8 0.47 10.8 3.7 2.3 2 0 0 2 2 2 0 Opy2 protein tRNA-synt_2b PF00587.25 EGD95762.1 - 5.4e-33 114.5 0.0 8.9e-33 113.7 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 EGD95762.1 - 0.00042 20.4 0.0 0.0026 17.9 0.0 2.2 3 0 0 3 3 3 1 Anticodon binding domain ECH_1 PF00378.20 EGD95763.1 - 4.9e-43 147.3 0.0 6.4e-43 146.9 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EGD95763.1 - 3.3e-26 92.6 0.2 5.8e-26 91.8 0.2 1.4 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Pyr_redox_2 PF07992.14 EGD95764.1 - 1.1e-54 185.6 0.9 1.8e-54 185.0 0.9 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 EGD95764.1 - 2.4e-29 101.8 0.3 1.1e-28 99.6 0.1 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 EGD95764.1 - 2.7e-14 53.5 0.1 2.7e-14 53.5 0.1 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EGD95764.1 - 1.7e-10 40.6 1.4 1.8e-09 37.3 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EGD95764.1 - 0.008 15.4 0.0 0.013 14.6 0.0 1.3 1 0 0 1 1 1 1 L-lysine 6-monooxygenase (NADPH-requiring) 3HCDH_N PF02737.18 EGD95764.1 - 0.014 15.3 0.1 0.033 14.1 0.1 1.7 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain FAD_oxidored PF12831.7 EGD95764.1 - 0.14 11.5 0.0 0.2 11.0 0.0 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase GIDA PF01134.22 EGD95764.1 - 0.2 10.7 2.4 0.67 9.0 0.4 2.7 3 1 1 4 4 4 0 Glucose inhibited division protein A Ank_2 PF12796.7 EGD95765.1 - 5.5e-08 33.3 0.2 0.00036 21.1 0.1 2.3 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EGD95765.1 - 9.2e-06 26.1 0.2 0.24 12.1 0.0 3.4 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 EGD95765.1 - 5.9e-05 23.3 0.1 0.013 15.8 0.0 2.3 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 EGD95765.1 - 0.1 13.1 0.4 30 5.3 0.1 3.6 3 1 0 3 3 3 0 Ankyrin repeat Pkinase PF00069.25 EGD95767.1 - 4.9e-53 180.2 0.0 1e-50 172.5 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EGD95767.1 - 1.2e-31 109.9 0.0 1.4e-30 106.4 0.0 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 EGD95767.1 - 0.0027 17.1 0.0 0.0043 16.4 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 EGD95767.1 - 0.0044 16.0 0.0 0.0064 15.5 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Seadorna_VP7 PF07387.11 EGD95767.1 - 0.0051 15.9 0.1 0.0093 15.1 0.1 1.3 1 0 0 1 1 1 1 Seadornavirus VP7 Pkinase_fungal PF17667.1 EGD95767.1 - 0.17 10.7 0.0 0.24 10.1 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase Mem_trans PF03547.18 EGD95769.1 - 2.7e-53 180.8 0.3 3.4e-53 180.4 0.3 1.1 1 0 0 1 1 1 1 Membrane transport protein Choline_kinase PF01633.20 EGD95770.1 - 2.1e-60 204.0 0.0 4.3e-60 202.9 0.0 1.5 1 0 0 1 1 1 1 Choline/ethanolamine kinase Choline_kin_N PF04428.14 EGD95770.1 - 6.9e-17 60.9 0.0 1.5e-16 59.8 0.0 1.6 1 0 0 1 1 1 1 Choline kinase N terminus APH PF01636.23 EGD95770.1 - 0.0011 18.9 0.2 0.0011 18.9 0.2 2.0 2 1 0 2 2 2 1 Phosphotransferase enzyme family Abhydrolase_2 PF02230.16 EGD95771.1 - 5.2e-23 82.0 0.1 3.6e-17 62.9 0.1 2.1 1 1 1 2 2 2 2 Phospholipase/Carboxylesterase FSH1 PF03959.13 EGD95771.1 - 0.0012 18.6 0.0 0.0025 17.5 0.0 1.5 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Peptidase_S9 PF00326.21 EGD95771.1 - 0.0063 16.0 0.5 0.016 14.7 0.5 1.7 1 1 0 1 1 1 1 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 EGD95771.1 - 0.03 13.6 0.1 0.12 11.6 0.0 2.0 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Glyco_hydro_31 PF01055.26 EGD95772.1 - 5.8e-169 562.9 0.4 8.2e-169 562.4 0.4 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 NtCtMGAM_N PF16863.5 EGD95772.1 - 6.4e-39 132.8 0.4 1.4e-38 131.6 0.4 1.6 1 0 0 1 1 1 1 N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase Gal_mutarotas_2 PF13802.6 EGD95772.1 - 3e-15 56.3 0.2 1.1e-14 54.5 0.2 2.0 1 0 0 1 1 1 1 Galactose mutarotase-like Asp PF00026.23 EGD95774.1 - 1.2e-05 24.9 0.5 0.00018 21.0 0.5 2.4 1 1 0 1 1 1 1 Eukaryotic aspartyl protease EphA2_TM PF14575.6 EGD95774.1 - 0.11 13.4 0.0 0.21 12.5 0.0 1.4 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Gram_pos_anchor PF00746.21 EGD95774.1 - 0.29 11.1 2.0 1.1 9.3 2.0 2.1 1 1 0 1 1 1 0 LPXTG cell wall anchor motif MFS_1 PF07690.16 EGD95775.1 - 1.6e-18 66.8 39.4 1.9e-12 46.8 27.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EGD95775.1 - 5.2e-14 51.9 23.0 5.3e-13 48.6 23.0 2.8 1 1 0 1 1 1 1 Sugar (and other) transporter Glyco_hydro_92 PF07971.12 EGD95776.1 - 1.4e-124 416.5 1.3 3.2e-122 408.8 1.3 2.1 1 1 0 1 1 1 1 Glycosyl hydrolase family 92 Glyco_hydro_92N PF17678.1 EGD95776.1 - 7.8e-47 160.2 2.6 1.3e-46 159.4 2.6 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 N-terminal domain ATP-synt_G PF04718.15 EGD95778.1 - 1e-33 116.1 0.1 4e-33 114.2 0.0 1.8 2 0 0 2 2 2 1 Mitochondrial ATP synthase g subunit ADH_zinc_N PF00107.26 EGD95779.1 - 2.5e-18 66.3 0.0 5.7e-18 65.1 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EGD95779.1 - 1.1e-16 62.1 0.0 2.3e-16 61.0 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EGD95779.1 - 6.1e-07 29.3 0.0 3.6e-06 26.8 0.0 2.1 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain Abhydrolase_1 PF00561.20 EGD95780.1 - 2.6e-14 53.5 0.0 7.9e-12 45.4 0.0 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EGD95780.1 - 0.019 14.3 0.0 0.028 13.7 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EGD95780.1 - 0.12 13.0 0.0 0.17 12.4 0.0 1.4 1 1 0 1 1 1 0 Alpha/beta hydrolase family PAP_central PF04928.17 EGD95781.1 - 2e-108 361.1 0.0 2.9e-108 360.5 0.0 1.2 1 0 0 1 1 1 1 Poly(A) polymerase central domain PAP_RNA-bind PF04926.15 EGD95781.1 - 3.5e-61 205.8 0.0 5.7e-61 205.1 0.0 1.3 1 0 0 1 1 1 1 Poly(A) polymerase predicted RNA binding domain NTP_transf_2 PF01909.23 EGD95781.1 - 1.7e-12 47.5 0.0 3.5e-12 46.5 0.0 1.5 1 0 0 1 1 1 1 Nucleotidyltransferase domain Nrap_D2 PF17403.2 EGD95781.1 - 0.14 11.9 0.1 0.27 11.0 0.1 1.5 1 0 0 1 1 1 0 Nrap protein PAP/OAS-like domain Glyco_transf_20 PF00982.21 EGD95782.1 - 5.6e-170 566.1 0.0 6.4e-170 565.9 0.0 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 20 Glyco_trans_1_4 PF13692.6 EGD95782.1 - 0.0006 20.3 0.0 0.0013 19.2 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glycos_transf_1 PF00534.20 EGD95782.1 - 0.0019 17.8 0.1 0.0045 16.5 0.0 1.7 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_transf_5 PF08323.11 EGD95782.1 - 0.0057 16.4 0.3 0.0092 15.7 0.3 1.3 1 0 0 1 1 1 1 Starch synthase catalytic domain adh_short_C2 PF13561.6 EGD95783.1 - 6.9e-43 146.9 2.4 8.5e-43 146.6 2.4 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EGD95783.1 - 1.9e-39 135.2 0.8 2.3e-39 134.9 0.8 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EGD95783.1 - 4.2e-11 43.1 0.3 6.5e-11 42.5 0.3 1.3 1 0 0 1 1 1 1 KR domain DUF429 PF04250.13 EGD95783.1 - 0.042 13.6 0.0 0.063 13.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF429) Amidase PF01425.21 EGD95784.1 - 1.6e-90 304.3 0.0 2e-90 304.0 0.0 1.1 1 0 0 1 1 1 1 Amidase Cation_efflux PF01545.21 EGD95785.1 - 4.8e-14 52.6 8.4 5.9e-14 52.3 8.4 1.1 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 EGD95785.1 - 1.2e-10 41.4 0.2 2.9e-10 40.1 0.2 1.6 1 0 0 1 1 1 1 Dimerisation domain of Zinc Transporter FlgN PF05130.12 EGD95785.1 - 0.089 13.3 2.9 0.19 12.3 2.9 1.4 1 0 0 1 1 1 0 FlgN protein Sulfotransfer_4 PF17784.1 EGD95786.1 - 2e-56 191.2 0.0 2.3e-56 191.0 0.0 1.0 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 EGD95786.1 - 0.00051 20.5 0.9 0.018 15.4 0.1 2.3 1 1 1 2 2 2 2 Sulfotransferase family Methyltransf_25 PF13649.6 EGD95787.1 - 4.6e-09 36.9 0.0 1.3e-08 35.4 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EGD95787.1 - 1.5e-07 32.0 0.0 3e-07 31.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EGD95787.1 - 1.4e-05 25.0 0.0 6.8e-05 22.8 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EGD95787.1 - 2.2e-05 24.3 0.0 5.1e-05 23.1 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EGD95787.1 - 0.00076 20.1 0.0 0.0099 16.5 0.0 2.7 2 1 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.18 EGD95787.1 - 0.0011 18.4 0.0 0.0022 17.4 0.0 1.5 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_20 PF12147.8 EGD95787.1 - 0.011 14.9 0.0 0.033 13.3 0.0 1.7 2 0 0 2 2 2 0 Putative methyltransferase BTRD1 PF17660.1 EGD95788.1 - 1.3e-31 108.1 4.9 2.5e-15 56.0 0.2 3.0 3 0 0 3 3 3 2 Bacterial tandem repeat domain 1 rve_2 PF13333.6 EGD95788.1 - 0.006 16.7 0.3 0.038 14.2 0.0 2.4 2 1 1 3 3 3 1 Integrase core domain FGAR-AT_linker PF18072.1 EGD95788.1 - 0.18 12.4 0.0 0.66 10.6 0.0 1.8 2 0 0 2 2 2 0 Formylglycinamide ribonucleotide amidotransferase linker domain 2_5_RNA_ligase2 PF13563.6 EGD95789.1 - 4.2e-33 114.4 0.1 1.1e-32 113.1 0.1 1.7 1 0 0 1 1 1 1 2'-5' RNA ligase superfamily PAP_central PF04928.17 EGD95789.1 - 5.4e-21 74.7 0.0 1.1e-20 73.7 0.0 1.5 1 0 0 1 1 1 1 Poly(A) polymerase central domain MJ1316 PF04457.12 EGD95789.1 - 2.3e-20 73.1 0.4 5.9e-20 71.8 0.4 1.8 1 0 0 1 1 1 1 MJ1316 RNA cyclic group end recognition domain Exo_endo_phos PF03372.23 EGD95789.1 - 1.9e-06 27.6 1.3 5.6e-06 26.0 1.3 1.8 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family NTP_transf_2 PF01909.23 EGD95789.1 - 0.00056 20.1 0.0 0.0023 18.2 0.0 1.9 2 0 0 2 2 2 1 Nucleotidyltransferase domain LigT_PEase PF02834.16 EGD95789.1 - 0.033 14.4 0.0 0.13 12.5 0.0 2.0 1 0 0 1 1 1 0 LigT like Phosphoesterase He_PIG PF05345.12 EGD95790.1 - 0.0058 16.8 0.7 0.023 14.9 0.2 2.3 2 0 0 2 2 2 1 Putative Ig domain UTRA PF07702.13 EGD95790.1 - 0.15 11.9 0.0 1.2 9.0 0.0 2.2 2 0 0 2 2 2 0 UTRA domain HNH_2 PF13391.6 EGD95793.1 - 7.5e-14 51.6 0.0 2.5e-13 49.9 0.0 1.9 1 1 0 1 1 1 1 HNH endonuclease Gon7 PF08738.10 EGD95794.1 - 2.3e-13 50.2 2.1 5.9e-13 48.8 2.1 1.6 1 1 0 1 1 1 1 Gon7 family Vps39_1 PF10366.9 EGD95795.1 - 3.2e-29 101.4 0.0 2.6e-28 98.4 0.0 2.6 3 0 0 3 3 3 1 Vacuolar sorting protein 39 domain 1 Vps39_2 PF10367.9 EGD95795.1 - 2.1e-21 76.4 0.1 1.3e-20 73.9 0.0 2.4 3 0 0 3 3 3 1 Vacuolar sorting protein 39 domain 2 CNH PF00780.22 EGD95795.1 - 9.6e-16 58.2 0.0 3e-15 56.6 0.0 1.8 1 1 0 1 1 1 1 CNH domain TPR_1 PF00515.28 EGD95795.1 - 0.0012 18.6 0.0 28 4.8 0.0 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat Clathrin PF00637.20 EGD95795.1 - 0.016 15.0 0.6 0.18 11.6 0.2 2.9 3 0 0 3 3 3 0 Region in Clathrin and VPS 6PF2K PF01591.18 EGD95796.1 - 3.3e-81 271.8 0.0 4.8e-81 271.3 0.0 1.1 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 EGD95796.1 - 5.3e-41 140.5 0.0 7.8e-41 139.9 0.0 1.3 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.6 EGD95796.1 - 1.6e-06 28.3 0.0 3e-06 27.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain APH PF01636.23 EGD95798.1 - 1.4e-18 67.7 0.0 3.3e-18 66.5 0.0 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EGD95798.1 - 0.00038 20.1 0.0 0.00086 18.9 0.0 1.5 1 0 0 1 1 1 1 Choline/ethanolamine kinase Pkinase PF00069.25 EGD95799.1 - 3.4e-22 79.1 0.0 5.2e-22 78.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD95799.1 - 5.3e-21 75.1 0.0 1e-20 74.1 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EGD95799.1 - 0.0052 16.7 0.2 1.3 8.9 0.0 2.1 1 1 1 2 2 2 2 Phosphotransferase enzyme family RIO1 PF01163.22 EGD95799.1 - 0.01 15.5 0.0 0.014 15.0 0.0 1.1 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.14 EGD95799.1 - 0.025 13.9 0.1 0.052 12.9 0.0 1.4 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EGD95799.1 - 0.11 11.8 0.0 0.23 10.7 0.0 1.6 1 1 0 1 1 1 0 Kinase-like DUF5353 PF17304.2 EGD95800.1 - 3.3e-35 119.6 2.1 5.1e-35 119.0 2.1 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF5353) Rotamase PF00639.21 EGD95800.1 - 0.00026 21.9 0.8 0.00037 21.4 0.8 1.3 1 0 0 1 1 1 1 PPIC-type PPIASE domain Ax_dynein_light PF10211.9 EGD95800.1 - 0.031 14.2 4.5 0.042 13.8 4.5 1.1 1 0 0 1 1 1 0 Axonemal dynein light chain OmpH PF03938.14 EGD95800.1 - 0.088 13.1 7.2 0.12 12.7 7.2 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF883 PF05957.13 EGD95800.1 - 0.16 12.6 4.0 0.29 11.8 4.0 1.4 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF883) YtxH PF12732.7 EGD95800.1 - 0.52 10.9 6.5 1.3 9.6 6.5 1.7 1 0 0 1 1 1 0 YtxH-like protein DUF4337 PF14235.6 EGD95800.1 - 0.95 9.6 4.5 1.4 9.0 4.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) ATP-synt_B PF00430.18 EGD95800.1 - 1.4 9.1 8.7 2.1 8.4 8.7 1.2 1 0 0 1 1 1 0 ATP synthase B/B' CF(0) DUF3292 PF11696.8 EGD95800.1 - 3.9 5.7 6.5 4.5 5.5 6.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) 2-oxoacid_dh PF00198.23 EGD95801.1 - 6e-75 251.7 0.0 7.5e-75 251.3 0.0 1.1 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 EGD95801.1 - 2.6e-17 62.4 0.4 2.6e-17 62.4 0.4 2.0 2 0 0 2 2 2 1 Biotin-requiring enzyme E3_binding PF02817.17 EGD95801.1 - 1e-15 57.8 1.2 2.8e-15 56.3 0.4 2.2 2 0 0 2 2 2 1 e3 binding domain SopE_GEF PF07487.13 EGD95801.1 - 0.04 14.0 0.0 0.078 13.1 0.0 1.4 1 0 0 1 1 1 0 SopE GEF domain Biotin_lipoyl_2 PF13533.6 EGD95801.1 - 0.082 12.7 0.0 0.24 11.3 0.0 1.7 1 0 0 1 1 1 0 Biotin-lipoyl like Sec7 PF01369.20 EGD95802.1 - 3.4e-69 232.2 0.2 9.3e-69 230.8 0.2 1.8 1 0 0 1 1 1 1 Sec7 domain Sec7_N PF12783.7 EGD95802.1 - 3.5e-43 147.2 5.3 3.5e-43 147.2 5.3 2.1 2 0 0 2 2 2 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DUF1981 PF09324.10 EGD95802.1 - 8.8e-35 118.4 5.1 1.4e-32 111.4 0.1 4.9 5 0 0 5 5 5 1 Domain of unknown function (DUF1981) DCB PF16213.5 EGD95802.1 - 1.6e-16 60.5 2.0 6.8e-16 58.4 0.1 2.8 3 0 0 3 3 3 1 Dimerisation and cyclophilin-binding domain of Mon2 NAD_binding_7 PF13241.6 EGD95804.1 - 1.7e-31 108.7 0.2 2.8e-31 108.1 0.2 1.3 1 0 0 1 1 1 1 Putative NAD(P)-binding Sirohm_synth_C PF14823.6 EGD95804.1 - 4.6e-29 99.9 0.0 7.1e-29 99.2 0.0 1.3 1 0 0 1 1 1 1 Sirohaem biosynthesis protein C-terminal Sirohm_synth_M PF14824.6 EGD95804.1 - 6.1e-15 54.4 0.1 1.2e-14 53.5 0.1 1.5 1 0 0 1 1 1 1 Sirohaem biosynthesis protein central Shikimate_DH PF01488.20 EGD95804.1 - 0.014 15.5 0.0 0.023 14.8 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Pyr_redox_3 PF13738.6 EGD95804.1 - 0.038 13.2 0.1 0.057 12.7 0.1 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase ThiF PF00899.21 EGD95804.1 - 0.17 11.2 1.9 0.29 10.5 0.3 1.9 1 1 1 2 2 2 0 ThiF family Pribosyltran_N PF13793.6 EGD95805.1 - 1.5e-44 150.7 0.3 2.5e-42 143.5 0.0 2.4 2 0 0 2 2 2 2 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.6 EGD95805.1 - 1.1e-33 116.8 0.1 5.9e-29 101.4 0.0 2.3 2 0 0 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.27 EGD95805.1 - 7.2e-11 41.8 0.0 2e-07 30.7 0.0 2.4 2 0 0 2 2 2 2 Phosphoribosyl transferase domain CbiJ PF02571.14 EGD95805.1 - 0.094 12.2 0.1 0.33 10.4 0.0 2.0 2 1 0 2 2 2 0 Precorrin-6x reductase CbiJ/CobK Isochorismatase PF00857.20 EGD95807.1 - 5.8e-21 75.5 0.0 7e-21 75.2 0.0 1.1 1 0 0 1 1 1 1 Isochorismatase family Methyltransf_10 PF05971.12 EGD95808.1 - 8.2e-71 238.8 0.0 1.1e-70 238.4 0.0 1.1 1 0 0 1 1 1 1 RNA methyltransferase MTS PF05175.14 EGD95808.1 - 1.8e-06 27.6 0.0 3e-06 26.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.13 EGD95808.1 - 0.00043 19.8 0.0 0.00071 19.1 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_18 PF12847.7 EGD95808.1 - 0.0089 16.0 0.0 0.016 15.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain UPF0020 PF01170.18 EGD95808.1 - 0.013 15.2 0.0 0.023 14.4 0.0 1.4 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 Methyltransf_25 PF13649.6 EGD95808.1 - 0.02 15.6 0.0 0.065 13.9 0.0 1.9 2 0 0 2 2 1 0 Methyltransferase domain Methyltransf_11 PF08241.12 EGD95808.1 - 0.021 15.5 0.0 0.07 13.8 0.0 1.9 2 0 0 2 2 1 0 Methyltransferase domain Methyltransf_31 PF13847.6 EGD95808.1 - 0.033 14.0 0.0 0.055 13.3 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.12 EGD95808.1 - 0.13 13.0 0.0 0.5 11.1 0.0 2.0 2 0 0 2 2 1 0 Methyltransferase domain AviRa PF11599.8 EGD95808.1 - 0.14 11.6 0.0 0.28 10.6 0.0 1.4 1 0 0 1 1 1 0 RRNA methyltransferase AviRa Methyltransf_33 PF10017.9 EGD95808.1 - 0.18 11.0 0.0 0.27 10.4 0.0 1.3 1 0 0 1 1 1 0 Histidine-specific methyltransferase, SAM-dependent TrmK PF04816.12 EGD95808.1 - 0.2 11.1 0.0 0.34 10.4 0.0 1.3 1 0 0 1 1 1 0 tRNA (adenine(22)-N(1))-methyltransferase Imm17 PF15562.6 EGD95808.1 - 1.6 8.7 3.1 9.8 6.1 0.0 2.6 2 0 0 2 2 2 0 Immunity protein 17 Complex1_LYR PF05347.15 EGD95809.1 - 0.00017 21.6 2.1 0.00039 20.4 2.1 1.6 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 EGD95809.1 - 0.53 11.1 5.2 0.6 10.9 3.5 1.9 2 0 0 2 2 2 0 Complex1_LYR-like Ank_4 PF13637.6 EGD95810.1 - 3.5e-10 40.2 0.7 3.3e-08 33.9 0.2 3.0 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 EGD95810.1 - 2.9e-06 27.8 0.1 0.013 16.0 0.3 2.5 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EGD95810.1 - 6e-05 23.2 1.7 0.0032 17.7 0.3 3.4 3 1 0 3 3 3 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EGD95810.1 - 0.0016 18.8 2.9 0.058 14.0 0.2 3.9 4 1 0 4 4 3 1 Ankyrin repeat KilA-N PF04383.13 EGD95810.1 - 0.0047 16.8 0.2 0.0047 16.8 0.2 2.7 2 1 0 2 2 2 1 KilA-N domain Sec8_exocyst PF04048.14 EGD95810.1 - 0.079 12.9 4.1 0.28 11.1 4.1 1.9 1 0 0 1 1 1 0 Sec8 exocyst complex component specific domain Mtr2 PF10429.9 EGD95810.1 - 0.089 12.7 0.0 0.17 11.8 0.0 1.4 1 0 0 1 1 1 0 Nuclear pore RNA shuttling protein Mtr2 FapA PF03961.13 EGD95810.1 - 0.11 11.1 5.4 0.2 10.2 5.4 1.3 1 0 0 1 1 1 0 Flagellar Assembly Protein A Baculo_PEP_C PF04513.12 EGD95810.1 - 0.15 12.1 1.1 0.98 9.5 0.3 2.3 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DivIC PF04977.15 EGD95810.1 - 4.2 7.2 6.9 59 3.5 4.4 2.9 2 0 0 2 2 2 0 Septum formation initiator Ank PF00023.30 EGD95810.1 - 4.8 7.8 8.0 5.5 7.6 0.4 3.8 4 0 0 4 4 4 0 Ankyrin repeat DUF4407 PF14362.6 EGD95810.1 - 6.8 5.9 14.4 6.9 5.9 5.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Rick_17kDa_Anti PF05433.15 EGD95811.1 - 0.0027 17.5 24.9 0.0068 16.2 24.9 1.8 1 0 0 1 1 1 1 Glycine zipper 2TM domain Gly-zipper_Omp PF13488.6 EGD95811.1 - 0.16 12.0 22.1 0.49 10.4 22.1 2.0 1 0 0 1 1 1 0 Glycine zipper DUF1275 PF06912.11 EGD95812.1 - 5.6e-43 147.1 12.6 8.1e-43 146.6 12.6 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1275) AzlC PF03591.14 EGD95812.1 - 4.1 7.8 9.8 0.48 10.9 3.0 2.6 1 1 1 2 2 2 0 AzlC protein Oxidored_q6 PF01058.22 EGD95813.1 - 5.4e-07 29.5 0.0 8.4e-07 28.9 0.0 1.2 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase, 20 Kd subunit TPR_11 PF13414.6 EGD95814.1 - 0.0015 18.1 0.0 0.006 16.2 0.0 2.2 1 0 0 1 1 1 1 TPR repeat TPR_1 PF00515.28 EGD95814.1 - 0.003 17.3 8.3 0.018 14.8 0.0 4.8 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_7 PF13176.6 EGD95814.1 - 0.0037 17.2 3.9 0.35 11.0 0.0 4.1 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_2 PF07719.17 EGD95814.1 - 0.025 14.7 0.0 0.025 14.7 0.0 4.8 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_19 PF14559.6 EGD95814.1 - 0.036 14.6 7.8 11 6.6 0.1 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_17 PF13431.6 EGD95814.1 - 0.061 13.7 0.1 3.9 8.1 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 EGD95814.1 - 0.17 12.6 0.0 0.17 12.6 0.0 5.0 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_9 PF13371.6 EGD95814.1 - 2.3 8.4 11.9 3.1 8.0 0.2 4.7 4 0 0 4 4 4 0 Tetratricopeptide repeat ABC_tran PF00005.27 EGD95815.1 - 2.1e-35 122.2 0.0 1.8e-23 83.5 0.0 3.2 2 1 0 2 2 2 2 ABC transporter 4HB PF17947.1 EGD95815.1 - 9.8e-30 102.5 0.8 2.7e-29 101.0 0.8 1.8 1 0 0 1 1 1 1 Four helical bundle domain AAA_21 PF13304.6 EGD95815.1 - 1.7e-13 51.0 0.0 0.0005 20.0 0.0 4.1 4 0 0 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EGD95815.1 - 8.3e-12 45.0 0.0 6.2e-07 29.1 0.0 2.6 2 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 EGD95815.1 - 2.6e-10 41.1 2.7 9.6e-05 23.0 0.2 2.9 3 0 0 3 3 3 2 AAA domain AAA_29 PF13555.6 EGD95815.1 - 3.3e-09 36.3 0.1 0.0026 17.5 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EGD95815.1 - 1.2e-08 35.1 0.1 8.7e-05 22.5 0.0 2.8 3 0 0 3 3 2 2 RsgA GTPase AAA_28 PF13521.6 EGD95815.1 - 3.5e-07 30.6 0.0 0.0093 16.2 0.0 2.8 2 0 0 2 2 2 2 AAA domain MMR_HSR1 PF01926.23 EGD95815.1 - 5.3e-07 29.7 0.0 0.0035 17.4 0.0 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_16 PF13191.6 EGD95815.1 - 1.2e-06 29.0 0.5 0.16 12.3 0.0 3.9 4 1 0 4 4 4 2 AAA ATPase domain AAA_18 PF13238.6 EGD95815.1 - 3.2e-06 27.7 0.1 0.085 13.4 0.0 2.9 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 EGD95815.1 - 5.3e-06 26.8 0.0 0.12 12.7 0.0 3.3 3 0 0 3 3 3 2 AAA domain PduV-EutP PF10662.9 EGD95815.1 - 1.4e-05 24.9 0.0 0.038 13.7 0.0 3.0 3 0 0 3 3 2 2 Ethanolamine utilisation - propanediol utilisation MeaB PF03308.16 EGD95815.1 - 1.9e-05 23.8 0.1 0.11 11.5 0.1 2.6 2 0 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB DUF87 PF01935.17 EGD95815.1 - 3.4e-05 24.0 0.0 0.15 12.1 0.0 2.7 2 0 0 2 2 2 2 Helicase HerA, central domain AAA PF00004.29 EGD95815.1 - 3.5e-05 24.3 0.0 0.12 12.8 0.0 3.2 3 0 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) AAA_15 PF13175.6 EGD95815.1 - 3.6e-05 23.7 0.0 0.34 10.6 0.0 3.2 3 0 0 3 3 3 2 AAA ATPase domain NACHT PF05729.12 EGD95815.1 - 5.2e-05 23.2 0.0 0.054 13.4 0.0 2.6 2 0 0 2 2 2 1 NACHT domain RNA_helicase PF00910.22 EGD95815.1 - 6.6e-05 23.3 0.0 0.46 10.9 0.0 2.7 2 0 0 2 2 2 2 RNA helicase AAA_33 PF13671.6 EGD95815.1 - 8.2e-05 22.8 0.0 0.32 11.1 0.0 2.7 2 0 0 2 2 2 2 AAA domain Dynamin_N PF00350.23 EGD95815.1 - 0.0001 22.4 0.1 0.0032 17.5 0.0 2.6 2 1 0 2 2 2 1 Dynamin family AAA_27 PF13514.6 EGD95815.1 - 0.00013 21.6 0.1 0.14 11.8 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.6 EGD95815.1 - 0.00018 21.3 0.0 0.67 9.6 0.0 3.1 3 0 0 3 3 3 2 AAA domain AAA_14 PF13173.6 EGD95815.1 - 0.00054 20.0 0.0 2.4 8.2 0.0 3.0 3 0 0 3 3 3 2 AAA domain AAA_30 PF13604.6 EGD95815.1 - 0.00057 19.7 0.0 1.5 8.5 0.0 3.1 3 0 0 3 3 3 1 AAA domain NB-ARC PF00931.22 EGD95815.1 - 0.00068 18.9 0.1 0.058 12.6 0.0 2.5 2 0 0 2 2 2 1 NB-ARC domain G-alpha PF00503.20 EGD95815.1 - 0.0013 17.9 0.0 1.1 8.3 0.0 2.3 2 0 0 2 2 2 2 G-protein alpha subunit Roc PF08477.13 EGD95815.1 - 0.0022 18.2 0.0 2.1 8.6 0.0 2.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase ATP_bind_1 PF03029.17 EGD95815.1 - 0.0035 17.2 0.0 2.5 7.8 0.0 2.6 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein cobW PF02492.19 EGD95815.1 - 0.004 16.8 0.1 4.8 6.7 0.0 3.2 3 0 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain MukB PF04310.12 EGD95815.1 - 0.0052 16.6 0.0 1.4 8.7 0.0 2.3 2 0 0 2 2 2 1 MukB N-terminal CLP1_P PF16575.5 EGD95815.1 - 0.008 16.0 0.0 0.86 9.4 0.0 2.7 2 0 0 2 2 2 1 mRNA cleavage and polyadenylation factor CLP1 P-loop Rad17 PF03215.15 EGD95815.1 - 0.01 15.8 0.0 0.78 9.6 0.0 2.4 2 0 0 2 2 2 0 Rad17 P-loop domain AAA_7 PF12775.7 EGD95815.1 - 0.01 15.4 0.0 2.6 7.5 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region Cytidylate_kin PF02224.18 EGD95815.1 - 0.011 15.5 0.0 2.3 7.9 0.0 2.4 2 0 0 2 2 2 0 Cytidylate kinase IstB_IS21 PF01695.17 EGD95815.1 - 0.011 15.5 0.0 7.8 6.2 0.0 2.8 3 0 0 3 3 2 0 IstB-like ATP binding protein ATP-synt_ab PF00006.25 EGD95815.1 - 0.011 15.4 0.0 6.3 6.4 0.0 2.5 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain ATPase_2 PF01637.18 EGD95815.1 - 0.012 15.5 0.1 2 8.2 0.0 2.8 3 0 0 3 3 2 0 ATPase domain predominantly from Archaea Ploopntkinase3 PF18751.1 EGD95815.1 - 0.014 15.3 0.0 3.8 7.4 0.0 2.4 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 Mg_chelatase PF01078.21 EGD95815.1 - 0.018 14.4 0.0 1.9 7.8 0.0 2.8 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 EGD95815.1 - 0.019 15.0 0.0 11 6.0 0.0 3.0 3 0 0 3 3 2 0 AAA domain (dynein-related subfamily) AAA_13 PF13166.6 EGD95815.1 - 0.02 13.5 3.1 1.9 7.0 0.0 3.3 3 1 1 4 4 4 0 AAA domain Septin PF00735.18 EGD95815.1 - 0.026 13.8 0.4 2.2 7.5 0.0 2.8 3 0 0 3 3 3 0 Septin AAA_25 PF13481.6 EGD95815.1 - 0.031 13.8 0.0 2.7 7.5 0.0 2.7 2 0 0 2 2 2 0 AAA domain DUF815 PF05673.13 EGD95815.1 - 0.037 13.2 0.0 7.1 5.7 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF815) T2SSE PF00437.20 EGD95815.1 - 0.05 12.7 0.1 3.7 6.5 0.0 2.4 2 0 0 2 2 2 0 Type II/IV secretion system protein dNK PF01712.19 EGD95815.1 - 0.07 13.0 0.0 1.3 8.8 0.0 2.3 2 0 0 2 2 2 0 Deoxynucleoside kinase NTPase_1 PF03266.15 EGD95815.1 - 0.093 12.6 0.1 11 5.9 0.1 2.7 2 0 0 2 2 2 0 NTPase TsaE PF02367.17 EGD95815.1 - 0.1 12.6 0.0 19 5.3 0.0 2.8 2 1 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Arf PF00025.21 EGD95815.1 - 0.12 11.8 0.0 5.8 6.3 0.0 2.4 2 0 0 2 2 2 0 ADP-ribosylation factor family FtsK_SpoIIIE PF01580.18 EGD95815.1 - 0.16 11.3 1.0 4.5 6.5 0.0 3.0 3 0 0 3 3 3 0 FtsK/SpoIIIE family FeoB_N PF02421.18 EGD95815.1 - 0.16 11.5 0.3 1.5 8.3 0.1 2.2 2 0 0 2 2 2 0 Ferrous iron transport protein B ABC2_membrane_3 PF12698.7 EGD95816.1 - 0.018 14.2 0.5 0.028 13.6 0.5 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein Orf78 PF06024.12 EGD95816.1 - 0.86 9.9 3.6 5.2 7.4 3.0 2.3 2 1 0 2 2 2 0 Orf78 (ac78) UCH PF00443.29 EGD95817.1 - 7.2e-70 235.4 0.7 1.5e-69 234.4 0.0 1.9 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase DUSP PF06337.12 EGD95817.1 - 4.9e-13 49.5 0.0 1.3e-12 48.2 0.0 1.8 1 0 0 1 1 1 1 DUSP domain UCH_1 PF13423.6 EGD95817.1 - 8.9e-12 45.2 0.7 6.1e-05 22.8 0.0 3.8 3 1 0 3 3 3 2 Ubiquitin carboxyl-terminal hydrolase USP7_C2 PF14533.6 EGD95817.1 - 0.0019 17.9 0.0 0.022 14.5 0.0 2.2 2 0 0 2 2 2 1 Ubiquitin-specific protease C-terminal PX PF00787.24 EGD95818.1 - 7.8e-19 67.7 0.0 3.2e-18 65.7 0.0 2.0 2 0 0 2 2 2 1 PX domain Vps5 PF09325.10 EGD95818.1 - 6e-08 32.5 6.6 0.00075 19.1 1.0 2.1 2 0 0 2 2 2 2 Vps5 C terminal like BAR PF03114.18 EGD95818.1 - 0.34 10.5 3.3 4.4 6.9 0.7 2.3 2 0 0 2 2 2 0 BAR domain DUF4554 PF15091.6 EGD95819.1 - 0.49 9.2 7.1 0.38 9.6 6.1 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4554) DUF4778 PF16008.5 EGD95819.1 - 2.6 8.0 11.7 3.5 7.6 11.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4778) DUF2428 PF10350.9 EGD95820.1 - 1.2e-46 159.1 0.7 2.5e-46 158.2 0.7 1.4 1 0 0 1 1 1 1 Putative death-receptor fusion protein (DUF2428) HEAT PF02985.22 EGD95820.1 - 0.099 13.0 0.2 9.7 6.8 0.0 4.3 4 0 0 4 4 4 0 HEAT repeat Tim17 PF02466.19 EGD95821.1 - 7.7e-28 97.1 3.4 1e-27 96.7 3.4 1.1 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family Pkinase PF00069.25 EGD95823.1 - 1.8e-45 155.4 0.0 2.8e-45 154.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD95823.1 - 1.9e-29 102.8 0.0 2.8e-29 102.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EGD95823.1 - 0.00049 19.0 0.0 0.0012 17.7 0.0 1.6 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 EGD95823.1 - 0.022 14.1 0.1 0.11 11.8 0.0 2.0 2 1 0 2 2 2 0 Kinase-like Kdo PF06293.14 EGD95823.1 - 0.055 12.8 0.0 0.092 12.1 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family UPF0547 PF10571.9 EGD95824.1 - 0.19 11.8 0.5 0.44 10.7 0.5 1.6 1 0 0 1 1 1 0 Uncharacterised protein family UPF0547 ILVD_EDD PF00920.21 EGD95826.1 - 3.6e-210 699.0 0.4 4.4e-210 698.7 0.4 1.1 1 0 0 1 1 1 1 Dehydratase family 5_nucleotid_C PF02872.18 EGD95826.1 - 0.1 12.8 0.1 0.49 10.6 0.0 2.1 2 0 0 2 2 2 0 5'-nucleotidase, C-terminal domain Lipase_3 PF01764.25 EGD95827.1 - 1.7e-19 70.1 0.0 3.8e-19 69.0 0.0 1.6 1 0 0 1 1 1 1 Lipase (class 3) RAI16-like PF10257.9 EGD95828.1 - 1.1e-78 264.6 0.0 1.7e-78 264.0 0.0 1.3 1 0 0 1 1 1 1 Retinoic acid induced 16-like protein BTB PF00651.31 EGD95830.1 - 0.0038 17.4 0.0 0.011 16.0 0.0 1.7 1 0 0 1 1 1 1 BTB/POZ domain SWIRM-assoc_2 PF16496.5 EGD95830.1 - 2.3 7.0 3.5 3.2 6.5 3.5 1.1 1 0 0 1 1 1 0 SWIRM-associated domain at the N-terminal CBFD_NFYB_HMF PF00808.23 EGD95831.1 - 5.1e-14 52.3 0.8 8e-14 51.7 0.8 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EGD95831.1 - 1.8e-05 25.1 3.9 1.8e-05 25.1 3.9 2.6 2 1 2 4 4 4 1 Core histone H2A/H2B/H3/H4 PAT1 PF09770.9 EGD95831.1 - 1.1 7.4 31.8 1.3 7.2 31.8 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Ndc1_Nup PF09531.10 EGD95831.1 - 9.6 4.8 15.9 11 4.6 15.9 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup zf-C3HC4_3 PF13920.6 EGD95832.1 - 0.003 17.4 10.3 0.0055 16.5 10.3 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Transposase_21 PF02992.14 EGD95832.1 - 0.1 11.9 0.3 0.24 10.6 0.0 1.7 2 0 0 2 2 2 0 Transposase family tnp2 DUF1899 PF08953.11 EGD95833.1 - 2.3e-32 110.6 0.0 5.2e-32 109.5 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1899) WD40_4 PF16300.5 EGD95833.1 - 5.2e-20 71.1 0.2 1.1e-19 70.0 0.2 1.6 1 0 0 1 1 1 1 Type of WD40 repeat WD40 PF00400.32 EGD95833.1 - 8.1e-17 61.3 4.4 0.00045 21.0 0.1 4.9 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EGD95833.1 - 5.2e-07 29.9 0.0 0.0022 18.3 0.1 3.0 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EGD95833.1 - 0.015 15.2 0.0 0.88 9.4 0.0 2.6 2 1 1 3 3 3 0 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 EGD95833.1 - 0.022 13.4 0.2 0.05 12.2 0.2 1.6 1 1 0 1 1 1 0 Nucleoporin Nup120/160 SlyX PF04102.12 EGD95833.1 - 0.038 14.6 0.2 0.078 13.6 0.2 1.5 1 0 0 1 1 1 0 SlyX ATG16 PF08614.11 EGD95833.1 - 1.5 9.0 4.8 3 8.0 4.8 1.5 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) Kinesin PF00225.23 EGD95834.1 - 1.5e-107 359.4 1.2 1.5e-107 359.4 1.2 2.2 2 1 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 EGD95834.1 - 2.6e-59 199.4 2.0 3.3e-59 199.1 0.0 2.2 2 0 0 2 2 2 1 Microtubule binding GARS_N PF02844.15 EGD95834.1 - 0.08 13.7 0.0 8.3 7.3 0.0 2.9 1 1 0 1 1 1 0 Phosphoribosylglycinamide synthetase, N domain AAA_16 PF13191.6 EGD95834.1 - 0.12 12.8 0.0 0.12 12.8 0.0 3.6 2 1 0 2 2 2 0 AAA ATPase domain AAA_24 PF13479.6 EGD95834.1 - 0.22 11.2 2.2 0.57 9.9 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 EGD95834.1 - 6.5 7.0 8.8 0.88 9.8 0.1 3.3 3 0 0 3 3 3 0 AAA domain Sugar_tr PF00083.24 EGD95835.1 - 1e-84 285.0 21.8 1.2e-84 284.8 21.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EGD95835.1 - 2.2e-14 53.2 33.7 6.2e-14 51.7 25.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Peptidase_S8 PF00082.22 EGD95836.1 - 1.2e-28 100.2 15.6 3e-28 98.9 15.6 1.6 1 1 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 EGD95836.1 - 1.3e-14 54.6 0.3 2e-14 54.0 0.3 1.3 1 0 0 1 1 1 1 Peptidase inhibitor I9 DUF3553 PF12073.8 EGD95836.1 - 0.0076 15.9 0.0 0.026 14.2 0.0 1.9 1 1 0 1 1 1 1 Protein of unknown function (DUF3553) Nramp PF01566.18 EGD95837.1 - 1.2e-86 290.9 26.6 1.5e-86 290.6 23.3 2.4 2 1 0 2 2 2 1 Natural resistance-associated macrophage protein Aminotran_4 PF01063.19 EGD95838.1 - 5.7e-26 91.8 0.0 7.5e-26 91.4 0.0 1.1 1 0 0 1 1 1 1 Amino-transferase class IV TPR_1 PF00515.28 EGD95839.1 - 1.6e-41 138.5 34.6 4.9e-06 26.1 0.1 11.4 10 1 1 11 11 11 10 Tetratricopeptide repeat TPR_2 PF07719.17 EGD95839.1 - 1.9e-39 130.6 34.0 7.9e-05 22.5 0.1 11.6 10 1 1 11 11 11 8 Tetratricopeptide repeat TPR_8 PF13181.6 EGD95839.1 - 3.8e-24 82.8 25.8 0.00031 20.7 0.0 10.7 10 0 0 10 10 10 5 Tetratricopeptide repeat TPR_16 PF13432.6 EGD95839.1 - 9.8e-21 74.1 21.9 3.7e-06 27.5 0.1 7.0 5 2 2 7 7 7 5 Tetratricopeptide repeat TPR_11 PF13414.6 EGD95839.1 - 2.7e-20 71.8 29.9 9e-07 28.5 0.1 9.2 7 2 3 10 10 10 5 TPR repeat TPR_17 PF13431.6 EGD95839.1 - 1.3e-17 62.9 18.4 0.012 16.0 0.0 9.1 8 2 0 8 8 8 6 Tetratricopeptide repeat TPR_12 PF13424.6 EGD95839.1 - 1.5e-16 60.5 36.4 0.00025 21.3 2.8 8.6 3 2 7 10 10 10 9 Tetratricopeptide repeat TPR_19 PF14559.6 EGD95839.1 - 4.6e-14 52.7 30.7 5.5e-06 26.8 2.4 8.1 6 2 0 8 8 8 3 Tetratricopeptide repeat TPR_9 PF13371.6 EGD95839.1 - 9.3e-14 51.3 16.6 7.6e-06 26.0 0.2 6.5 4 2 4 8 8 7 3 Tetratricopeptide repeat TPR_7 PF13176.6 EGD95839.1 - 1.2e-12 46.8 24.3 0.0097 15.9 0.6 9.8 9 1 1 10 10 9 3 Tetratricopeptide repeat TPR_14 PF13428.6 EGD95839.1 - 2.1e-11 43.7 24.9 0.038 14.8 1.1 10.1 3 3 9 12 12 11 4 Tetratricopeptide repeat TPR_10 PF13374.6 EGD95839.1 - 3e-07 30.1 27.7 0.052 13.4 1.0 9.6 11 0 0 11 11 10 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EGD95839.1 - 3.8e-07 30.2 19.6 0.087 13.1 0.4 5.9 3 2 1 5 5 5 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_MalT PF17874.1 EGD95839.1 - 2.1e-06 27.3 9.4 8.1e-05 22.1 4.4 4.0 2 1 2 4 4 4 2 MalT-like TPR region SHNi-TPR PF10516.9 EGD95839.1 - 2.1e-05 23.8 12.2 0.18 11.3 0.0 7.7 8 0 0 8 8 8 1 SHNi-TPR MAS20 PF02064.15 EGD95839.1 - 0.0026 17.9 7.6 0.013 15.6 0.6 4.0 4 1 1 5 5 5 1 MAS20 protein import receptor TAF1_subA PF14929.6 EGD95839.1 - 0.0034 16.8 0.8 0.0086 15.5 0.4 1.8 2 1 0 2 2 2 1 TAF RNA Polymerase I subunit A DUF3856 PF12968.7 EGD95839.1 - 0.0067 16.5 4.6 7.2 6.7 0.0 4.9 4 3 0 4 4 4 0 Domain of Unknown Function (DUF3856) Sel1 PF08238.12 EGD95839.1 - 0.019 15.6 5.8 0.92 10.3 0.1 4.2 4 0 0 4 4 2 0 Sel1 repeat MIT PF04212.18 EGD95839.1 - 0.022 14.8 13.7 9 6.4 0.3 6.7 7 0 0 7 7 6 0 MIT (microtubule interacting and transport) domain Transglut_prok PF09017.10 EGD95839.1 - 0.044 13.1 1.4 0.96 8.7 0.0 2.3 2 0 0 2 2 2 0 Microbial transglutaminase Wzy_C_2 PF11846.8 EGD95839.1 - 0.045 13.7 0.7 16 5.3 0.0 3.5 2 1 1 3 3 3 0 Virulence factor membrane-bound polymerase, C-terminal FAT PF02259.23 EGD95839.1 - 0.052 12.8 2.2 8.5 5.5 0.3 3.2 3 1 0 3 3 3 0 FAT domain TPR_6 PF13174.6 EGD95839.1 - 0.17 12.6 28.6 9.6 7.1 0.9 9.3 11 0 0 11 11 9 0 Tetratricopeptide repeat HemY_N PF07219.13 EGD95839.1 - 0.2 11.9 9.8 42 4.4 2.0 4.6 4 1 0 4 4 3 0 HemY protein N-terminus TPR_4 PF07721.14 EGD95839.1 - 0.22 12.2 6.9 1.7e+02 3.3 0.2 6.4 7 0 0 7 7 5 0 Tetratricopeptide repeat Alkyl_sulf_dimr PF14863.6 EGD95839.1 - 0.96 9.9 4.5 26 5.2 0.1 3.9 3 2 0 3 3 3 0 Alkyl sulfatase dimerisation CMS1 PF14617.6 EGD95839.1 - 1.7 7.9 5.6 3.2 7.0 5.6 1.4 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit BCIP PF13862.6 EGD95839.1 - 5.1 6.8 5.8 2.9 7.6 0.0 2.3 2 0 0 2 2 2 0 p21-C-terminal region-binding protein NARP1 PF12569.8 EGD95839.1 - 8.6 5.1 29.3 0.095 11.6 0.3 4.6 2 2 2 4 4 4 0 NMDA receptor-regulated protein 1 FHA PF00498.26 EGD95840.1 - 4e-11 43.1 0.8 6.1e-11 42.5 0.3 1.6 2 0 0 2 2 2 1 FHA domain Yop-YscD_cpl PF16697.5 EGD95840.1 - 0.003 17.8 0.0 0.0061 16.9 0.0 1.4 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain Sec1 PF00995.23 EGD95842.1 - 1.2e-127 427.6 0.0 1.4e-127 427.4 0.0 1.0 1 0 0 1 1 1 1 Sec1 family CEP19 PF14933.6 EGD95843.1 - 1.1 9.5 6.8 0.19 12.0 1.5 2.4 2 0 0 2 2 2 0 CEP19-like protein HORMA PF02301.18 EGD95844.1 - 4.9e-34 117.8 0.0 5.7e-34 117.6 0.0 1.0 1 0 0 1 1 1 1 HORMA domain ATG101 PF07855.12 EGD95844.1 - 0.0031 17.5 0.4 0.014 15.4 0.4 2.0 1 1 0 1 1 1 1 Autophagy-related protein 101 DUF2660 PF10859.8 EGD95844.1 - 0.02 15.3 0.1 0.099 13.1 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2660) bacHORMA_2 PF18173.1 EGD95844.1 - 0.095 12.5 0.0 0.15 11.9 0.0 1.5 1 0 0 1 1 1 0 Bacterial HORMA domain 2 GTP_EFTU PF00009.27 EGD95845.1 - 3.6e-50 170.2 0.0 5.7e-50 169.6 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain LepA_C PF06421.12 EGD95845.1 - 4.3e-43 145.8 2.6 6.8e-43 145.2 2.6 1.3 1 0 0 1 1 1 1 GTP-binding protein LepA C-terminus EFG_C PF00679.24 EGD95845.1 - 1.2e-20 73.3 0.0 2.2e-20 72.5 0.0 1.5 1 0 0 1 1 1 1 Elongation factor G C-terminus Ras PF00071.22 EGD95845.1 - 2.9e-05 23.7 0.0 0.00021 20.9 0.0 2.1 2 0 0 2 2 2 1 Ras family MMR_HSR1 PF01926.23 EGD95845.1 - 0.00012 22.2 0.0 0.00035 20.6 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D2 PF03144.25 EGD95845.1 - 0.00042 20.6 0.8 0.00079 19.8 0.1 1.9 2 0 0 2 2 2 1 Elongation factor Tu domain 2 EFG_II PF14492.6 EGD95845.1 - 0.00086 19.4 0.0 0.0022 18.0 0.0 1.8 1 0 0 1 1 1 1 Elongation Factor G, domain II RF3_C PF16658.5 EGD95845.1 - 0.0094 15.8 0.0 0.024 14.5 0.0 1.7 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain SRPRB PF09439.10 EGD95845.1 - 0.023 14.2 0.0 0.052 13.0 0.0 1.6 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit MMR_HSR1_Xtn PF16897.5 EGD95845.1 - 0.062 13.3 0.0 0.14 12.2 0.0 1.5 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain p450 PF00067.22 EGD95846.1 - 1.9e-31 109.4 0.0 2.8e-31 108.8 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 Methyltransf_25 PF13649.6 EGD95847.1 - 0.00045 20.9 0.0 0.91 10.3 0.0 2.4 1 1 1 2 2 2 2 Methyltransferase domain Methyltransf_11 PF08241.12 EGD95847.1 - 0.0027 18.3 0.0 0.29 11.8 0.0 2.3 1 1 1 2 2 2 2 Methyltransferase domain Methyltransf_31 PF13847.6 EGD95847.1 - 0.014 15.2 0.0 0.32 10.8 0.0 2.6 1 1 2 3 3 3 0 Methyltransferase domain Methyltransf_12 PF08242.12 EGD95847.1 - 0.097 13.4 0.0 1.5 9.7 0.0 2.3 1 1 1 2 2 2 0 Methyltransferase domain DUF3328 PF11807.8 EGD95848.1 - 1.2e-21 77.5 4.3 2.8e-20 73.1 4.3 2.3 1 1 0 1 1 1 1 Domain of unknown function (DUF3328) FAD_binding_4 PF01565.23 EGD95850.1 - 1.3e-24 86.5 5.4 2e-24 85.9 5.4 1.3 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EGD95850.1 - 9.3e-09 35.3 0.0 1.9e-08 34.3 0.0 1.5 1 0 0 1 1 1 1 Berberine and berberine like Trypsin_2 PF13365.6 EGD95851.1 - 0.00047 21.1 0.1 0.0017 19.3 0.1 1.8 1 1 0 1 1 1 1 Trypsin-like peptidase domain Peptidase_S64 PF08192.11 EGD95851.1 - 0.0012 17.4 0.3 0.2 10.1 0.1 2.1 2 0 0 2 2 2 2 Peptidase family S64 Peptidase_S29 PF02907.15 EGD95851.1 - 0.042 13.6 0.0 0.079 12.7 0.0 1.4 1 0 0 1 1 1 0 Hepatitis C virus NS3 protease Tfb5 PF06331.12 EGD95852.1 - 1e-15 57.4 0.1 1.3e-15 57.1 0.1 1.2 1 0 0 1 1 1 1 Transcription factor TFIIH complex subunit Tfb5 ECH_1 PF00378.20 EGD95853.1 - 7.4e-43 146.7 0.0 1.2e-42 146.0 0.0 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EGD95853.1 - 3.2e-30 105.8 0.0 1.6e-29 103.4 0.0 1.7 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase 2OG-FeII_Oxy_2 PF13532.6 EGD95854.1 - 1.8e-26 93.5 0.1 3.4e-26 92.6 0.1 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Isochorismatase PF00857.20 EGD95854.1 - 2e-21 77.0 0.0 9.4e-15 55.2 0.0 2.3 2 0 0 2 2 2 2 Isochorismatase family GST_N PF02798.20 EGD95854.1 - 0.015 15.6 0.0 0.062 13.7 0.0 2.1 2 0 0 2 2 2 0 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 EGD95854.1 - 0.024 15.0 0.0 0.09 13.2 0.0 2.0 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EGD95854.1 - 0.034 14.3 0.0 0.12 12.6 0.0 1.9 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain Glutaredoxin2_C PF04399.13 EGD95854.1 - 0.085 12.7 0.0 0.17 11.7 0.0 1.4 1 0 0 1 1 1 0 Glutaredoxin 2, C terminal domain GST_N_2 PF13409.6 EGD95854.1 - 0.14 12.5 0.0 0.58 10.5 0.0 2.0 2 0 0 2 2 2 0 Glutathione S-transferase, N-terminal domain IlvN PF07991.12 EGD95855.1 - 4.5e-46 156.4 0.0 7.3e-46 155.8 0.0 1.2 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain IlvC PF01450.19 EGD95855.1 - 1.4e-40 138.9 0.0 2.6e-40 138.1 0.0 1.5 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain NAD_binding_2 PF03446.15 EGD95855.1 - 0.01 16.0 0.0 0.02 15.0 0.0 1.5 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 EGD95855.1 - 0.14 12.7 0.2 0.4 11.3 0.0 2.0 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent GGACT PF06094.12 EGD95857.1 - 0.015 15.9 0.0 0.025 15.2 0.0 1.4 1 1 0 1 1 1 0 Gamma-glutamyl cyclotransferase, AIG2-like PALP PF00291.25 EGD95858.1 - 5.8e-65 219.6 0.2 7.8e-65 219.2 0.2 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme DegT_DnrJ_EryC1 PF01041.17 EGD95858.1 - 0.0015 17.9 0.0 0.0025 17.2 0.0 1.3 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Rad51 PF08423.11 EGD95859.1 - 0.0035 16.6 0.0 0.013 14.8 0.0 1.8 2 0 0 2 2 2 1 Rad51 Mitochondr_Som1 PF11093.8 EGD95861.1 - 7.1e-20 70.8 0.0 8.1e-20 70.6 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial export protein Som1 TAF8_C PF10406.9 EGD95862.1 - 1e-20 74.0 0.6 3e-20 72.5 0.6 1.9 1 0 0 1 1 1 1 Transcription factor TFIID complex subunit 8 C-term Bromo_TP PF07524.13 EGD95862.1 - 1.1e-05 25.4 0.0 2.6e-05 24.2 0.0 1.6 1 0 0 1 1 1 1 Bromodomain associated Tir_receptor_C PF07489.11 EGD95862.1 - 0.098 12.6 12.4 0.21 11.5 12.4 1.5 1 0 0 1 1 1 0 Translocated intimin receptor (Tir) C-terminus Dicty_REP PF05086.12 EGD95862.1 - 0.098 10.6 3.1 0.13 10.2 3.1 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein FSA_C PF10479.9 EGD95862.1 - 0.26 9.4 2.7 0.36 8.9 2.7 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Mucin PF01456.17 EGD95862.1 - 0.73 9.8 22.4 1.6 8.7 22.4 1.5 1 0 0 1 1 1 0 Mucin-like glycoprotein DUF3439 PF11921.8 EGD95862.1 - 0.99 9.4 17.6 2 8.4 17.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Sporozoite_P67 PF05642.11 EGD95862.1 - 8.1 4.4 9.7 12 3.8 9.7 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen COX6C PF02937.15 EGD95863.1 - 0.048 13.8 0.0 0.055 13.6 0.0 1.1 1 0 0 1 1 1 0 Cytochrome c oxidase subunit VIc UQ_con PF00179.26 EGD95864.1 - 8.9e-36 122.6 0.0 1.1e-35 122.3 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EGD95864.1 - 0.092 12.4 0.0 0.11 12.2 0.0 1.2 1 0 0 1 1 1 0 Prokaryotic E2 family B Chitin_synth_1 PF01644.17 EGD95865.1 - 4.7e-69 231.5 0.0 6.8e-69 231.0 0.0 1.2 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_1N PF08407.11 EGD95865.1 - 2.7e-28 97.7 0.0 5.1e-28 96.8 0.0 1.5 1 0 0 1 1 1 1 Chitin synthase N-terminal Chitin_synth_2 PF03142.15 EGD95865.1 - 9.2e-23 80.6 0.1 3.6e-18 65.5 0.0 2.1 2 0 0 2 2 2 2 Chitin synthase Glyco_trans_2_3 PF13632.6 EGD95865.1 - 6.5e-09 36.0 0.1 6.5e-09 36.0 0.1 2.6 4 0 0 4 4 4 1 Glycosyl transferase family group 2 Psu PF07455.11 EGD95865.1 - 0.0032 17.1 0.0 3.1 7.4 0.0 2.3 2 0 0 2 2 2 2 Phage polarity suppression protein (Psu) AMP-binding PF00501.28 EGD95866.1 - 1.5e-46 158.9 0.0 2e-46 158.5 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EGD95866.1 - 0.099 13.6 0.1 0.2 12.7 0.1 1.5 1 0 0 1 1 1 0 AMP-binding enzyme C-terminal domain Opy2 PF09463.10 EGD95867.1 - 1.6e-09 37.9 19.9 2.7e-09 37.2 19.9 1.4 1 0 0 1 1 1 1 Opy2 protein SKG6 PF08693.10 EGD95867.1 - 2.7e-05 23.4 0.3 2.7e-05 23.4 0.3 2.2 2 0 0 2 2 2 1 Transmembrane alpha-helix domain Beta-APP PF03494.13 EGD95867.1 - 0.069 13.0 1.4 0.14 12.1 1.4 1.4 1 0 0 1 1 1 0 Beta-amyloid peptide (beta-APP) Dicty_REP PF05086.12 EGD95867.1 - 0.24 9.3 9.7 0.32 8.9 9.7 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DUF3439 PF11921.8 EGD95867.1 - 0.56 10.2 10.4 4.5 7.2 9.3 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) Tmemb_cc2 PF10267.9 EGD95867.1 - 1.2 8.2 9.9 1.8 7.7 9.9 1.2 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein DUF5401 PF17380.2 EGD95867.1 - 7.1 4.6 14.5 9.8 4.1 14.5 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5401) Rrn6 PF10214.9 EGD95868.1 - 2.3 6.6 6.2 2.9 6.3 6.2 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor Methyltransf_23 PF13489.6 EGD95870.1 - 4.4e-05 23.4 0.0 6.3e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EGD95870.1 - 7.9e-05 23.3 0.0 0.00018 22.2 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EGD95870.1 - 0.00019 22.0 0.0 0.00035 21.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EGD95870.1 - 0.0044 16.8 0.0 0.0095 15.7 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EGD95870.1 - 0.0083 16.8 0.0 0.016 15.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain TehB PF03848.14 EGD95870.1 - 0.025 14.0 0.0 0.037 13.4 0.0 1.2 1 0 0 1 1 1 0 Tellurite resistance protein TehB CheR PF01739.18 EGD95870.1 - 0.049 13.1 0.0 0.078 12.4 0.0 1.2 1 0 0 1 1 1 0 CheR methyltransferase, SAM binding domain ZZ PF00569.17 EGD95871.1 - 6.3e-15 54.7 26.6 3.7e-10 39.4 10.8 2.4 2 0 0 2 2 2 2 Zinc finger, ZZ type HET PF06985.11 EGD95871.1 - 6.7e-11 42.7 6.3 9.6e-09 35.7 1.0 2.4 1 1 1 2 2 2 2 Heterokaryon incompatibility protein (HET) C1_2 PF03107.16 EGD95871.1 - 2.3e-09 37.4 23.2 0.00014 22.1 3.7 2.5 2 0 0 2 2 2 2 C1 domain F-box PF00646.33 EGD95872.1 - 0.0017 18.1 0.3 0.042 13.7 0.0 2.8 2 0 0 2 2 2 1 F-box domain F-box_4 PF15966.5 EGD95872.1 - 0.14 12.1 0.0 0.42 10.5 0.0 2.0 1 0 0 1 1 1 0 F-box Phosphoesterase PF04185.14 EGD95874.1 - 6.3e-71 239.4 0.9 9.2e-71 238.9 0.9 1.2 1 0 0 1 1 1 1 Phosphoesterase family Cu-oxidase_3 PF07732.15 EGD95875.1 - 2.4e-44 150.1 0.9 2.7e-42 143.6 0.1 3.0 3 0 0 3 3 3 1 Multicopper oxidase Cu-oxidase_2 PF07731.14 EGD95875.1 - 8.3e-36 122.7 8.8 6.1e-35 119.9 2.8 3.1 2 1 0 2 2 2 2 Multicopper oxidase Cu-oxidase PF00394.22 EGD95875.1 - 1.7e-14 54.2 0.0 2.3e-12 47.3 0.0 3.0 3 0 0 3 3 3 1 Multicopper oxidase WW PF00397.26 EGD95876.1 - 1.8e-06 27.9 0.4 4.2e-06 26.8 0.4 1.7 1 0 0 1 1 1 1 WW domain TFIIA PF03153.13 EGD95876.1 - 0.043 13.8 8.5 0.054 13.5 8.5 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CobD_Cbib PF03186.13 EGD95876.1 - 0.12 11.6 0.1 0.16 11.2 0.1 1.2 1 0 0 1 1 1 0 CobD/Cbib protein zf-C2H2 PF00096.26 EGD95877.1 - 5.5e-06 26.5 35.5 0.00074 19.8 4.5 4.5 5 0 0 5 5 5 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EGD95877.1 - 0.00021 21.8 31.7 0.0031 18.2 2.5 4.5 4 0 0 4 4 4 3 C2H2-type zinc finger zf-C2H2_11 PF16622.5 EGD95877.1 - 0.0025 17.5 14.8 0.12 12.1 0.4 3.7 3 0 0 3 3 3 2 zinc-finger C2H2-type zf-H2C2_2 PF13465.6 EGD95877.1 - 0.0055 17.1 18.7 0.21 12.1 0.3 4.0 4 0 0 4 4 4 3 Zinc-finger double domain zf-C2H2_6 PF13912.6 EGD95877.1 - 0.047 13.7 12.8 0.077 13.0 0.2 3.4 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2_8 PF15909.5 EGD95877.1 - 0.048 13.9 7.9 0.76 10.1 7.5 2.9 1 1 1 2 2 2 0 C2H2-type zinc ribbon CpXC PF14353.6 EGD95877.1 - 0.055 13.5 6.5 1.3 9.1 0.4 2.5 1 1 1 2 2 2 0 CpXC protein Zn-ribbon_8 PF09723.10 EGD95877.1 - 0.11 12.7 9.6 1.1 9.5 2.2 2.8 2 0 0 2 2 2 0 Zinc ribbon domain zinc-ribbons_6 PF07191.12 EGD95877.1 - 0.92 9.5 7.3 0.65 10.0 0.3 2.7 2 0 0 2 2 2 0 zinc-ribbons Rubredoxin_2 PF18073.1 EGD95877.1 - 2.1 8.2 8.1 8.7 6.2 1.2 2.8 2 0 0 2 2 2 0 Rubredoxin metal binding domain Pkinase PF00069.25 EGD95879.1 - 3.2e-17 62.8 0.0 1.1e-16 61.0 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain WD40 PF00400.32 EGD95879.1 - 3.3e-08 34.0 9.5 3.2e-05 24.6 0.0 5.4 4 0 0 4 4 4 2 WD domain, G-beta repeat HEAT PF02985.22 EGD95879.1 - 8.8e-08 31.8 10.4 0.25 11.7 0.0 6.5 7 0 0 7 7 7 3 HEAT repeat HEAT_EZ PF13513.6 EGD95879.1 - 0.0028 18.1 0.1 0.26 11.9 0.1 3.4 3 0 0 3 3 3 1 HEAT-like repeat Ge1_WD40 PF16529.5 EGD95879.1 - 0.017 14.1 0.0 0.36 9.8 0.0 2.8 3 0 0 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Pkinase_Tyr PF07714.17 EGD95879.1 - 0.033 13.5 0.0 0.066 12.5 0.0 1.4 1 1 0 1 1 1 0 Protein tyrosine kinase Tti2 PF10521.9 EGD95879.1 - 0.053 13.0 0.1 0.12 11.9 0.1 1.5 1 0 0 1 1 1 0 Tti2 family RabGAP-TBC PF00566.18 EGD95880.1 - 4e-42 144.3 0.0 2.4e-40 138.5 0.0 2.2 2 0 0 2 2 2 2 Rab-GTPase-TBC domain DUF3322 PF11795.8 EGD95880.1 - 0.26 11.3 2.3 0.23 11.4 0.3 1.9 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria N-term (DUF3322) Peptidase_M6 PF05547.11 EGD95881.1 - 4.1e-06 25.5 1.2 0.00028 19.4 0.5 2.2 2 0 0 2 2 2 2 Immune inhibitor A peptidase M6 Abhydrolase_4 PF08386.10 EGD95883.1 - 0.08 13.1 0.0 0.12 12.5 0.0 1.3 1 0 0 1 1 1 0 TAP-like protein COesterase PF00135.28 EGD95885.1 - 3e-89 300.2 0.0 3.6e-89 300.0 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EGD95885.1 - 2.4e-06 27.6 0.0 6.6e-06 26.1 0.0 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EGD95885.1 - 0.00053 19.5 0.0 0.001 18.6 0.0 1.5 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_6 PF12697.7 EGD95885.1 - 0.0012 19.5 0.0 0.0036 17.9 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family DUF1749 PF08538.10 EGD95885.1 - 0.05 12.7 0.0 0.071 12.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1749) SmpA_OmlA PF04355.13 EGD95885.1 - 0.058 13.2 0.3 11 5.9 0.0 2.6 2 0 0 2 2 2 0 SmpA / OmlA family Nop14 PF04147.12 EGD95886.1 - 1.2e-291 970.0 22.6 1.6e-291 969.7 22.6 1.1 1 0 0 1 1 1 1 Nop14-like family Cylicin_N PF15241.6 EGD95886.1 - 6.9 6.8 9.4 1.2 9.3 0.5 3.2 3 0 0 3 3 3 0 Cylicin N-terminus HEAT_2 PF13646.6 EGD95887.1 - 0.018 15.4 0.2 0.038 14.4 0.2 1.5 1 0 0 1 1 1 0 HEAT repeats PaaA_PaaC PF05138.12 EGD95887.1 - 0.12 11.5 0.0 0.18 10.9 0.0 1.2 1 0 0 1 1 1 0 Phenylacetic acid catabolic protein PPR_2 PF13041.6 EGD95888.1 - 2.8e-09 37.0 0.0 0.38 11.0 0.0 5.7 5 0 0 5 5 5 3 PPR repeat family PPR PF01535.20 EGD95888.1 - 0.0032 17.6 0.6 6.5 7.2 0.0 5.0 6 0 0 6 6 6 1 PPR repeat PPR_3 PF13812.6 EGD95888.1 - 0.0045 17.0 0.1 1 9.5 0.0 3.3 3 0 0 3 3 3 1 Pentatricopeptide repeat domain ORC3_N PF07034.11 EGD95889.1 - 3.8e-37 128.1 0.0 5.9e-22 78.2 0.0 2.4 2 0 0 2 2 2 2 Origin recognition complex (ORC) subunit 3 N-terminus ORC_WH_C PF18137.1 EGD95889.1 - 5.7e-24 84.8 0.4 2.2e-15 57.0 0.0 2.8 2 1 1 3 3 3 2 Origin recognition complex winged helix C-terminal DUF3456 PF11938.8 EGD95889.1 - 0.039 14.5 0.1 0.089 13.3 0.1 1.6 1 0 0 1 1 1 0 TLR4 regulator and MIR-interacting MSAP Symplekin_C PF12295.8 EGD95889.1 - 0.053 13.6 0.1 0.33 11.0 0.0 2.3 3 0 0 3 3 3 0 Symplekin tight junction protein C terminal Sec66 PF09802.9 EGD95890.1 - 9.9e-79 263.1 0.7 1.2e-78 262.8 0.7 1.1 1 0 0 1 1 1 1 Preprotein translocase subunit Sec66 DUF3848 PF12959.7 EGD95890.1 - 0.00017 21.6 0.1 0.00033 20.7 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3848) DUF1539 PF07560.11 EGD95890.1 - 0.017 15.2 0.0 0.038 14.1 0.0 1.6 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1539) DUF2465 PF10239.9 EGD95890.1 - 0.027 13.7 0.1 0.04 13.1 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2465) AAA PF00004.29 EGD95891.1 - 3.7e-46 156.8 0.1 1.6e-41 141.8 0.0 2.8 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EGD95891.1 - 4.9e-10 39.1 0.0 2.5e-09 36.8 0.0 2.2 2 0 0 2 2 1 1 AAA+ lid domain IstB_IS21 PF01695.17 EGD95891.1 - 8.7e-07 28.8 0.0 2.7e-06 27.3 0.0 1.7 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_16 PF13191.6 EGD95891.1 - 9.8e-07 29.3 0.0 2.2e-05 24.9 0.0 3.1 2 0 0 2 2 2 1 AAA ATPase domain AAA_2 PF07724.14 EGD95891.1 - 1.2e-05 25.5 0.0 3e-05 24.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) Bromodomain PF00439.25 EGD95891.1 - 0.00019 21.4 0.0 0.00049 20.1 0.0 1.6 1 0 0 1 1 1 1 Bromodomain AAA_5 PF07728.14 EGD95891.1 - 0.00083 19.4 0.0 0.0027 17.7 0.0 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EGD95891.1 - 0.0034 17.7 0.3 0.083 13.2 0.3 3.0 1 1 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 EGD95891.1 - 0.0049 17.2 0.0 0.018 15.5 0.0 2.0 2 0 0 2 2 1 1 RNA helicase AAA_33 PF13671.6 EGD95891.1 - 0.0089 16.2 0.0 0.03 14.5 0.0 2.0 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.6 EGD95891.1 - 0.013 15.1 0.0 0.04 13.5 0.0 1.8 2 0 0 2 2 1 0 AAA domain TIP49 PF06068.13 EGD95891.1 - 0.018 14.3 0.0 0.028 13.6 0.0 1.2 1 0 0 1 1 1 0 TIP49 P-loop domain AAA_14 PF13173.6 EGD95891.1 - 0.019 15.0 0.0 0.057 13.5 0.0 1.8 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 EGD95891.1 - 0.029 14.9 0.0 0.099 13.2 0.0 1.9 1 0 0 1 1 1 0 ABC transporter AAA_30 PF13604.6 EGD95891.1 - 0.034 13.9 0.0 0.075 12.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 EGD95891.1 - 0.044 13.1 0.0 0.096 12.1 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 EGD95891.1 - 0.07 13.7 0.0 0.27 11.8 0.0 2.1 1 0 0 1 1 1 0 AAA domain RuvB_N PF05496.12 EGD95891.1 - 0.075 12.8 0.0 0.16 11.7 0.0 1.5 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain Sigma54_activat PF00158.26 EGD95891.1 - 0.081 12.6 0.0 3.2 7.4 0.0 2.7 3 0 0 3 3 3 0 Sigma-54 interaction domain NACHT PF05729.12 EGD95891.1 - 0.088 12.7 0.0 0.31 10.9 0.0 2.0 1 0 0 1 1 1 0 NACHT domain Sigma54_activ_2 PF14532.6 EGD95891.1 - 0.099 12.8 0.0 1.9 8.6 0.0 2.4 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_3 PF07726.11 EGD95891.1 - 0.15 12.0 0.0 0.27 11.1 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) PhoH PF02562.16 EGD95891.1 - 0.17 11.3 0.0 0.33 10.4 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein Parvo_NS1 PF01057.17 EGD95891.1 - 0.2 10.7 0.0 0.35 9.9 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_11 PF13086.6 EGD95891.1 - 0.86 9.3 0.0 0.86 9.3 0.0 3.7 3 0 0 3 3 1 0 AAA domain DUF5470 PF17564.2 EGD95892.1 - 0.018 15.2 0.6 0.03 14.5 0.6 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5470) Cauli_AT PF03233.13 EGD95892.1 - 0.1 12.5 0.5 0.15 12.0 0.5 1.3 1 1 0 1 1 1 0 Aphid transmission protein CPSF_A PF03178.15 EGD95893.1 - 1.3e-100 336.9 0.0 4.3e-100 335.2 0.0 1.9 2 0 0 2 2 2 1 CPSF A subunit region MMS1_N PF10433.9 EGD95893.1 - 1.9e-15 56.5 0.0 3.2e-15 55.8 0.0 1.3 1 0 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term MFS_1 PF07690.16 EGD95894.1 - 1.6e-46 158.9 40.0 2.2e-42 145.3 41.0 2.5 2 1 0 2 2 2 2 Major Facilitator Superfamily PALP PF00291.25 EGD95895.1 - 3.2e-34 118.7 0.0 2.7e-32 112.4 0.0 2.1 2 0 0 2 2 2 2 Pyridoxal-phosphate dependent enzyme Rhodanese PF00581.20 EGD95895.1 - 8.1e-10 39.2 0.0 4.5e-09 36.8 0.0 2.2 1 1 0 1 1 1 1 Rhodanese-like domain Pkinase PF00069.25 EGD95896.1 - 2.3e-32 112.4 0.0 2.7e-32 112.2 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD95896.1 - 1.3e-26 93.5 0.0 1.7e-26 93.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EGD95896.1 - 4.7e-05 22.3 0.0 5e-05 22.3 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 EGD95896.1 - 6.9e-05 21.9 0.1 8.8e-05 21.6 0.1 1.2 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 EGD95896.1 - 0.0002 21.4 0.1 0.0059 16.6 0.0 2.0 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.6 EGD95896.1 - 0.018 14.4 0.1 0.88 8.8 0.2 2.6 1 1 1 2 2 2 0 Kinase-like RIO1 PF01163.22 EGD95896.1 - 0.044 13.4 0.1 0.073 12.7 0.1 1.3 1 1 0 1 1 1 0 RIO1 family AAA_11 PF13086.6 EGD95898.1 - 5.1e-64 216.6 0.4 1.1e-63 215.5 0.4 1.6 1 0 0 1 1 1 1 AAA domain AAA_12 PF13087.6 EGD95898.1 - 3.3e-57 193.3 0.0 9.8e-57 191.8 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 EGD95898.1 - 1.3e-13 51.1 0.0 2.4e-12 47.0 0.0 2.7 2 1 0 2 2 1 1 AAA domain AAA_19 PF13245.6 EGD95898.1 - 7.6e-11 42.5 0.0 4.7e-10 40.0 0.0 2.4 3 1 0 3 3 1 1 AAA domain Viral_helicase1 PF01443.18 EGD95898.1 - 1.6e-09 37.9 0.1 0.072 12.8 0.0 3.3 3 0 0 3 3 3 3 Viral (Superfamily 1) RNA helicase ResIII PF04851.15 EGD95898.1 - 1.9e-07 31.2 0.0 5.9e-07 29.6 0.0 1.8 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit DUF2075 PF09848.9 EGD95898.1 - 3e-07 30.0 0.2 3.1e-06 26.7 0.2 2.2 1 1 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_22 PF13401.6 EGD95898.1 - 1.3e-05 25.5 0.1 0.00012 22.3 0.1 2.4 1 1 0 1 1 1 1 AAA domain PIF1 PF05970.14 EGD95898.1 - 1.4e-05 24.5 0.0 0.13 11.4 0.0 2.5 2 0 0 2 2 2 2 PIF1-like helicase Helicase_RecD PF05127.14 EGD95898.1 - 3.6e-05 23.7 0.0 0.0045 16.8 0.0 3.2 2 1 0 2 2 2 1 Helicase UvrD-helicase PF00580.21 EGD95898.1 - 0.00015 21.4 0.3 0.0014 18.2 0.4 2.1 1 1 0 1 1 1 1 UvrD/REP helicase N-terminal domain AAA_16 PF13191.6 EGD95898.1 - 0.00018 22.0 0.1 0.00054 20.4 0.1 1.9 1 0 0 1 1 1 1 AAA ATPase domain T2SSE PF00437.20 EGD95898.1 - 0.00021 20.4 0.0 0.00041 19.5 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein PhoH PF02562.16 EGD95898.1 - 0.00042 19.8 0.0 0.013 15.0 0.0 2.8 2 1 0 2 2 1 1 PhoH-like protein Flavi_DEAD PF07652.14 EGD95898.1 - 0.0007 19.6 0.1 0.002 18.1 0.1 1.8 1 0 0 1 1 1 1 Flavivirus DEAD domain TrwB_AAD_bind PF10412.9 EGD95898.1 - 0.0023 16.9 0.0 0.005 15.8 0.0 1.5 1 0 0 1 1 1 1 Type IV secretion-system coupling protein DNA-binding domain AAA_5 PF07728.14 EGD95898.1 - 0.0048 16.9 0.0 0.031 14.3 0.0 2.3 1 1 1 2 2 2 1 AAA domain (dynein-related subfamily) UvrD_C PF13361.6 EGD95898.1 - 0.0052 16.2 0.6 2 7.7 0.0 3.0 2 2 0 3 3 3 1 UvrD-like helicase C-terminal domain AAA PF00004.29 EGD95898.1 - 0.011 16.2 0.2 0.058 13.8 0.2 2.4 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 EGD95898.1 - 0.011 15.5 0.0 0.042 13.6 0.0 2.1 1 1 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 EGD95898.1 - 0.014 15.1 0.0 0.033 13.9 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein UvrD_C_2 PF13538.6 EGD95898.1 - 0.017 14.9 0.0 0.2 11.5 0.0 2.3 2 0 0 2 2 2 0 UvrD-like helicase C-terminal domain 4HB_MCP_1 PF12729.7 EGD95898.1 - 0.03 13.9 0.0 0.07 12.7 0.0 1.5 1 0 0 1 1 1 0 Four helix bundle sensory module for signal transduction CbiA PF01656.23 EGD95898.1 - 0.034 14.2 0.0 0.12 12.4 0.0 2.0 2 0 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain TK PF00265.18 EGD95898.1 - 0.047 13.6 0.0 0.64 9.9 0.0 2.3 2 0 0 2 2 2 0 Thymidine kinase SRP54 PF00448.22 EGD95898.1 - 0.049 13.3 0.0 1.2 8.7 0.0 2.3 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_33 PF13671.6 EGD95898.1 - 0.084 13.0 0.0 0.29 11.3 0.0 2.0 2 0 0 2 2 1 0 AAA domain Rad17 PF03215.15 EGD95898.1 - 0.11 12.4 0.1 0.75 9.7 0.0 2.1 1 1 1 2 2 2 0 Rad17 P-loop domain AAA_23 PF13476.6 EGD95898.1 - 0.11 12.9 0.0 1.2 9.6 0.0 2.3 2 0 0 2 2 2 0 AAA domain CmcI PF04989.12 EGD95898.1 - 0.12 12.1 0.0 0.27 10.9 0.0 1.5 1 1 1 2 2 2 0 Cephalosporin hydroxylase Herpes_ori_bp PF02399.15 EGD95898.1 - 0.12 10.4 0.0 0.18 9.8 0.0 1.2 1 0 0 1 1 1 0 Origin of replication binding protein Mg_chelatase PF01078.21 EGD95898.1 - 0.12 11.7 0.0 0.22 10.9 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_7 PF12775.7 EGD95898.1 - 0.15 11.6 0.0 0.5 9.9 0.0 2.0 1 0 0 1 1 1 0 P-loop containing dynein motor region RNA_helicase PF00910.22 EGD95898.1 - 0.19 12.1 0.0 0.5 10.8 0.0 1.7 1 0 0 1 1 1 0 RNA helicase PCB_OB PF17092.5 EGD95898.1 - 0.26 12.1 1.1 15 6.4 0.3 3.1 2 1 1 3 3 3 0 Penicillin-binding protein OB-like domain HhH-GPD PF00730.25 EGD95899.1 - 1.3e-20 73.8 0.0 2.9e-20 72.7 0.0 1.6 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 EGD95899.1 - 3.4e-07 29.8 0.0 1.2e-06 28.1 0.0 2.0 1 0 0 1 1 1 1 Helix-hairpin-helix motif UQ_con PF00179.26 EGD95900.1 - 1.5e-39 134.8 0.0 1.8e-39 134.6 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EGD95900.1 - 0.019 14.7 0.0 0.022 14.5 0.0 1.3 1 0 0 1 1 1 0 Prokaryotic E2 family B UFC1 PF08694.11 EGD95900.1 - 0.058 13.0 0.0 0.063 12.9 0.0 1.2 1 0 0 1 1 1 0 Ubiquitin-fold modifier-conjugating enzyme 1 Methyltransf_23 PF13489.6 EGD95901.1 - 1.7e-21 76.8 0.0 2.9e-21 76.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EGD95901.1 - 6.5e-11 42.8 0.0 2.2e-10 41.1 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EGD95901.1 - 5.5e-08 32.8 0.0 1.9e-06 27.7 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EGD95901.1 - 1.7e-07 31.9 0.0 9e-07 29.6 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EGD95901.1 - 1.9e-06 28.4 0.0 5e-06 27.1 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EGD95901.1 - 0.0017 17.9 0.0 0.0031 17.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_4 PF02390.17 EGD95901.1 - 0.0019 17.7 0.0 0.0034 16.9 0.0 1.4 1 0 0 1 1 1 1 Putative methyltransferase FtsJ PF01728.19 EGD95901.1 - 0.023 14.8 0.0 0.037 14.1 0.0 1.3 1 0 0 1 1 1 0 FtsJ-like methyltransferase DUF1461 PF07314.11 EGD95901.1 - 0.11 12.3 0.0 0.2 11.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1461) Ubie_methyltran PF01209.18 EGD95901.1 - 0.15 11.4 0.0 0.46 9.8 0.0 1.7 2 0 0 2 2 2 0 ubiE/COQ5 methyltransferase family PCMT PF01135.19 EGD95901.1 - 0.19 11.5 0.0 6 6.6 0.0 2.2 1 1 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) PT PF04886.12 EGD95902.1 - 2e-06 27.3 187.3 77 2.9 2.1 9.3 3 2 1 4 4 4 1 PT repeat SoxY PF13501.6 EGD95902.1 - 0.14 12.4 0.0 0.23 11.7 0.0 1.3 1 0 0 1 1 1 0 Sulfur oxidation protein SoxY Papilin_u7 PF16626.5 EGD95903.1 - 0.024 15.2 0.8 0.045 14.3 0.8 1.7 1 1 0 1 1 1 0 Linking region between Kunitz_BPTI and I-set on papilin MBOAT_2 PF13813.6 EGD95904.1 - 1.2e-12 47.9 0.7 3.9e-12 46.3 0.7 1.9 1 0 0 1 1 1 1 Membrane bound O-acyl transferase family DUF1467 PF07330.12 EGD95904.1 - 3.2 7.8 8.3 2.7 8.0 0.2 3.5 4 0 0 4 4 4 0 Protein of unknown function (DUF1467) p450 PF00067.22 EGD95905.1 - 2.9e-53 181.3 0.0 3.7e-53 180.9 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 AMP-binding PF00501.28 EGD95906.1 - 1.6e-30 106.1 0.0 1.2e-29 103.1 0.0 1.9 1 1 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EGD95906.1 - 2.2e-06 28.6 0.0 5.5e-06 27.3 0.0 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Cu_amine_oxid PF01179.20 EGD95907.1 - 9.8e-167 555.0 0.3 1.2e-166 554.7 0.3 1.1 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain Cu_amine_oxidN3 PF02728.16 EGD95907.1 - 4.8e-05 23.7 0.0 0.00011 22.5 0.0 1.6 1 0 0 1 1 1 1 Copper amine oxidase, N3 domain Cu_amine_oxidN2 PF02727.16 EGD95907.1 - 0.022 15.0 0.0 0.045 14.0 0.0 1.5 1 0 0 1 1 1 0 Copper amine oxidase, N2 domain Tim17 PF02466.19 EGD95908.1 - 9.9e-10 38.8 1.4 1.6e-09 38.1 1.4 1.2 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family zf-rbx1 PF12678.7 EGD95910.1 - 0.00018 21.7 4.0 0.0006 20.0 4.0 1.9 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 EGD95910.1 - 0.0023 18.2 6.1 0.0023 18.2 6.1 2.1 2 0 0 2 2 2 1 Ring finger domain zf-ANAPC11 PF12861.7 EGD95910.1 - 0.024 14.7 4.1 0.024 14.7 4.1 1.8 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger COesterase PF00135.28 EGD95911.1 - 1.8e-67 228.4 0.3 5.6e-52 177.3 0.6 3.0 2 1 1 3 3 3 3 Carboxylesterase family Abhydrolase_3 PF07859.13 EGD95911.1 - 0.00014 21.8 0.0 0.00027 20.9 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold LapA_dom PF06305.11 EGD95912.1 - 0.0085 15.9 2.3 2.2 8.2 0.2 2.8 2 0 0 2 2 2 2 Lipopolysaccharide assembly protein A domain CitMHS PF03600.16 EGD95912.1 - 0.013 14.7 4.1 0.043 13.0 4.1 1.7 1 1 0 1 1 1 0 Citrate transporter Glyco_hydro_3 PF00933.21 EGD95913.1 - 1.1e-52 179.5 0.0 1.5e-52 179.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain LIM PF00412.22 EGD95914.1 - 1.2e-16 60.6 19.2 2.3e-11 43.8 3.2 3.3 3 1 0 3 3 3 2 LIM domain Peptidase_S10 PF00450.22 EGD95916.1 - 1.1e-74 252.3 0.2 1.4e-74 252.0 0.2 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase Ribonucleas_3_3 PF14622.6 EGD95918.1 - 6.7e-07 29.5 0.0 9.7e-07 29.0 0.0 1.2 1 0 0 1 1 1 1 Ribonuclease-III-like Ribonuclease_3 PF00636.26 EGD95918.1 - 0.00062 20.3 0.0 0.0042 17.7 0.0 2.0 1 1 0 1 1 1 1 Ribonuclease III domain NAD_binding_5 PF07994.12 EGD95920.1 - 4.5e-145 483.0 0.1 5.5e-145 482.7 0.1 1.1 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase Inos-1-P_synth PF01658.17 EGD95920.1 - 2.5e-45 153.2 0.6 6e-45 152.0 0.6 1.7 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase PepSY PF03413.19 EGD95920.1 - 0.19 12.3 1.6 17 6.1 0.5 2.6 2 0 0 2 2 2 0 Peptidase propeptide and YPEB domain Amidase PF01425.21 EGD95922.1 - 7.8e-82 275.6 0.1 6.7e-80 269.2 0.1 2.1 1 1 0 1 1 1 1 Amidase RhoGAP PF00620.27 EGD95923.1 - 1.8e-38 131.7 0.0 3e-38 131.0 0.0 1.3 1 0 0 1 1 1 1 RhoGAP domain SesA PF17107.5 EGD95925.1 - 3.4e-38 130.6 0.3 5e-38 130.0 0.3 1.2 1 0 0 1 1 1 1 N-terminal domain on NACHT_NTPase and P-loop NTPases NACHT_sigma PF17106.5 EGD95925.1 - 8e-12 45.1 10.9 8e-12 45.1 10.9 1.6 2 0 0 2 2 2 1 Sigma domain on NACHT-NTPases DUF2802 PF10975.8 EGD95925.1 - 0.12 12.5 0.9 0.21 11.7 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2802) SesA PF17107.5 EGD95926.1 - 1.9e-27 95.9 0.0 3.2e-27 95.1 0.0 1.3 2 0 0 2 2 2 1 N-terminal domain on NACHT_NTPase and P-loop NTPases NACHT_sigma PF17106.5 EGD95926.1 - 7.9e-11 41.9 7.1 1.3e-10 41.2 7.1 1.4 1 0 0 1 1 1 1 Sigma domain on NACHT-NTPases WD40 PF00400.32 EGD95927.1 - 7.3e-116 374.8 75.5 6.5e-10 39.4 0.6 14.6 15 0 0 15 15 14 13 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EGD95927.1 - 2e-35 121.0 22.2 0.0017 18.6 0.1 12.6 1 1 11 12 12 12 10 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EGD95927.1 - 6.6e-20 71.3 30.7 0.02 13.6 0.0 10.8 4 3 7 11 11 11 8 Nucleoporin Nup120/160 NACHT PF05729.12 EGD95927.1 - 8.4e-19 68.1 0.0 1.6e-18 67.2 0.0 1.4 1 0 0 1 1 1 1 NACHT domain Ank_2 PF12796.7 EGD95927.1 - 3.4e-13 50.0 0.4 0.00018 22.0 0.0 4.3 3 2 2 5 5 4 2 Ankyrin repeats (3 copies) eIF2A PF08662.11 EGD95927.1 - 3e-11 43.6 3.4 0.0031 17.4 0.1 4.8 3 2 1 4 4 4 3 Eukaryotic translation initiation factor eIF2A Ank_4 PF13637.6 EGD95927.1 - 1.8e-08 34.7 0.0 0.00075 20.0 0.0 3.3 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ge1_WD40 PF16529.5 EGD95927.1 - 2.2e-08 33.5 20.8 0.0081 15.2 2.1 8.3 1 1 5 8 8 8 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Ank PF00023.30 EGD95927.1 - 1.4e-07 31.6 0.4 0.024 15.1 0.0 4.5 4 0 0 4 4 4 2 Ankyrin repeat WD40_like PF17005.5 EGD95927.1 - 6.6e-07 28.9 2.1 0.11 11.9 0.1 4.6 5 0 0 5 5 5 2 WD40-like domain Ank_3 PF13606.6 EGD95927.1 - 9.2e-07 28.7 0.0 0.004 17.5 0.0 4.3 3 0 0 3 3 3 1 Ankyrin repeat Ank_5 PF13857.6 EGD95927.1 - 3.8e-06 27.1 0.0 0.32 11.4 0.0 3.4 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Nucleoporin_N PF08801.11 EGD95927.1 - 9.5e-06 24.6 19.2 0.029 13.1 0.1 6.2 2 2 1 5 5 5 2 Nup133 N terminal like AAA_16 PF13191.6 EGD95927.1 - 6.5e-05 23.4 0.0 0.00016 22.1 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain HPS3_N PF14761.6 EGD95927.1 - 0.00021 20.9 0.0 2.2 7.8 0.0 4.2 4 0 0 4 4 4 1 Hermansky-Pudlak syndrome 3 NACHT_sigma PF17106.5 EGD95927.1 - 0.0014 18.8 1.8 0.0029 17.7 1.8 1.5 1 0 0 1 1 1 1 Sigma domain on NACHT-NTPases Cytochrom_D1 PF02239.16 EGD95927.1 - 0.013 14.0 11.1 0.55 8.7 0.4 4.2 2 1 3 6 6 6 0 Cytochrome D1 heme domain DUF5046 PF16465.5 EGD95927.1 - 0.047 13.1 0.2 0.5 9.8 0.1 2.6 2 1 0 3 3 3 0 Domain of unknown function (DUF5046) AAA_19 PF13245.6 EGD95927.1 - 0.081 13.3 0.0 0.22 11.8 0.0 1.8 1 1 0 1 1 1 0 AAA domain Methyltransf_PK PF05891.12 EGD95928.1 - 2.6e-66 223.3 0.0 3e-66 223.1 0.0 1.0 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Methyltransf_11 PF08241.12 EGD95928.1 - 1.2e-05 25.8 0.1 4.4e-05 24.0 0.1 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EGD95928.1 - 3e-05 23.9 0.0 0.00012 22.0 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EGD95928.1 - 6.2e-05 23.6 0.1 0.00037 21.2 0.1 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_2 PF00891.18 EGD95928.1 - 0.078 12.3 0.0 0.14 11.4 0.0 1.4 1 0 0 1 1 1 0 O-methyltransferase domain APH PF01636.23 EGD95930.1 - 9e-10 38.9 0.0 4.6e-09 36.6 0.0 2.1 1 1 0 1 1 1 1 Phosphotransferase enzyme family Pkinase PF00069.25 EGD95933.1 - 3.3e-25 88.9 0.0 1.6e-24 86.7 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD95933.1 - 1.9e-08 33.9 0.1 1.5e-07 30.9 0.1 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase zf-Tim10_DDP PF02953.15 EGD95934.1 - 4.5e-16 58.3 3.7 4.5e-16 58.3 3.7 1.4 1 1 0 1 1 1 1 Tim10/DDP family zinc finger YqzH PF14164.6 EGD95934.1 - 0.043 13.9 1.1 0.15 12.2 0.7 2.1 2 1 0 2 2 2 0 YqzH-like protein ADH_N PF08240.12 EGD95935.1 - 1.2e-26 92.8 0.8 2.8e-26 91.5 0.8 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EGD95935.1 - 7.3e-19 68.0 0.2 1.4e-18 67.1 0.2 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 EGD95935.1 - 0.00028 20.3 0.7 0.00048 19.5 0.7 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Sacchrp_dh_NADP PF03435.18 EGD95935.1 - 0.0078 16.5 0.2 0.029 14.6 0.1 1.9 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain Amidase PF01425.21 EGD95936.1 - 9.2e-93 311.6 0.0 1.6e-91 307.5 0.0 2.0 1 1 0 1 1 1 1 Amidase PIG-F PF06699.11 EGD95937.1 - 1.5e-65 220.7 7.0 1.7e-65 220.5 7.0 1.0 1 0 0 1 1 1 1 GPI biosynthesis protein family Pig-F ATPase_gene1 PF09527.10 EGD95937.1 - 2.3 8.4 10.7 0.19 11.9 4.0 2.5 2 0 0 2 2 2 0 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter Gly-zipper_OmpA PF13436.6 EGD95937.1 - 5.5 6.9 12.2 3.2 7.6 0.6 3.5 3 0 0 3 3 3 0 Glycine-zipper domain FlxA PF14282.6 EGD95938.1 - 0.28 11.2 1.5 7.4 6.6 1.1 2.4 2 0 0 2 2 2 0 FlxA-like protein DUF4470 PF14737.6 EGD95939.1 - 4.9e-25 87.6 0.2 1.5e-24 86.0 0.1 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4470) zf-MYND PF01753.18 EGD95939.1 - 1e-10 41.5 10.2 2.1e-10 40.5 10.2 1.5 1 0 0 1 1 1 1 MYND finger PHINT_rpt PF14882.6 EGD95940.1 - 0.0039 17.4 0.1 0.0082 16.4 0.1 1.5 1 0 0 1 1 1 1 Phage-integrase repeat unit NTP_transf_5 PF14907.6 EGD95940.1 - 0.042 13.5 0.6 0.34 10.5 0.6 2.0 1 1 0 1 1 1 0 Uncharacterised nucleotidyltransferase LMBR1 PF04791.16 EGD95941.1 - 7.5e-17 61.4 5.1 7.5e-17 61.4 5.1 2.4 2 1 0 3 3 3 2 LMBR1-like membrane protein DUF5367 PF17329.2 EGD95941.1 - 0.028 14.5 2.2 0.028 14.5 2.2 4.4 7 0 0 7 7 7 0 Family of unknown function (DUF5367) SLATT_1 PF18181.1 EGD95942.1 - 0.047 13.6 1.2 0.079 12.9 0.5 1.6 1 1 1 2 2 2 0 SMODS and SLOG-associating 2TM effector domain 1 CREPT PF16566.5 EGD95942.1 - 0.55 10.4 4.2 1.3 9.2 4.2 1.5 1 1 0 1 1 1 0 Cell-cycle alteration and expression-elevated protein in tumour Atg14 PF10186.9 EGD95943.1 - 2.7e-85 286.3 0.0 3.6e-85 285.8 0.0 1.1 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 BBP1_C PF15272.6 EGD95943.1 - 0.078 12.8 4.2 0.13 12.1 4.2 1.2 1 0 0 1 1 1 0 Spindle pole body component BBP1, C-terminal Filament PF00038.21 EGD95943.1 - 0.24 10.9 6.7 1.8 8.1 7.4 1.8 2 0 0 2 2 2 0 Intermediate filament protein DUF1192 PF06698.11 EGD95943.1 - 0.33 11.1 3.5 1 9.5 3.5 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1192) Prefoldin_2 PF01920.20 EGD95943.1 - 0.37 10.8 1.5 1.7 8.6 0.1 2.1 2 0 0 2 2 2 0 Prefoldin subunit DUF4200 PF13863.6 EGD95943.1 - 1.7 9.1 6.4 2.9 8.3 6.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) CREPT PF16566.5 EGD95944.1 - 0.13 12.4 0.0 0.22 11.7 0.0 1.2 1 0 0 1 1 1 0 Cell-cycle alteration and expression-elevated protein in tumour Pkinase PF00069.25 EGD95945.1 - 5.5e-09 35.8 0.0 1e-08 34.9 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD95945.1 - 5.1e-07 29.2 0.0 9.7e-07 28.3 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Choline_kinase PF01633.20 EGD95945.1 - 0.0011 18.6 0.0 0.0047 16.6 0.0 1.8 2 0 0 2 2 2 1 Choline/ethanolamine kinase DUF2401 PF10287.9 EGD95946.1 - 9.4e-76 254.4 0.0 1.5e-75 253.7 0.0 1.3 1 0 0 1 1 1 1 Putative TOS1-like glycosyl hydrolase (DUF2401) DUF2403 PF10290.9 EGD95946.1 - 2.4e-22 79.1 0.2 6.2e-22 77.8 0.2 1.7 1 0 0 1 1 1 1 Glycine-rich protein domain (DUF2403) Zip PF02535.22 EGD95947.1 - 2e-50 171.9 7.1 4.6e-50 170.7 7.1 1.6 1 1 0 1 1 1 1 ZIP Zinc transporter KRTAP PF11759.8 EGD95947.1 - 0.11 13.1 2.1 0.29 11.7 2.1 1.7 1 0 0 1 1 1 0 Keratin-associated matrix Thiolase_N PF00108.23 EGD95948.1 - 7.1e-93 310.7 0.2 1.1e-92 310.1 0.2 1.3 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 EGD95948.1 - 2.6e-44 149.8 1.7 5.8e-44 148.7 1.1 1.9 2 0 0 2 2 2 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 EGD95948.1 - 7.6e-06 25.7 1.4 3.1e-05 23.7 1.4 2.1 1 1 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III PF08545.10 EGD95948.1 - 0.065 13.1 1.5 2.2 8.2 0.1 3.1 3 0 0 3 3 3 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III LysM PF01476.20 EGD95949.1 - 5.1e-13 48.9 0.0 2e-05 24.5 0.0 4.2 4 0 0 4 4 4 3 LysM domain UPF0203 PF05254.12 EGD95949.1 - 0.0044 17.2 9.8 1.8 8.8 0.0 4.7 4 2 0 4 4 4 2 Uncharacterised protein family (UPF0203) Rab15_effector PF15208.6 EGD95949.1 - 0.0073 15.6 0.0 2.8 7.2 0.0 2.6 3 0 0 3 3 3 2 Rab15 effector CarbpepA_inh PF02977.15 EGD95949.1 - 0.016 15.0 5.2 17 5.3 0.0 5.0 5 0 0 5 5 5 0 Carboxypeptidase A inhibitor GTP_EFTU PF00009.27 EGD95950.1 - 3.8e-47 160.3 0.0 5.9e-47 159.7 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFTUD2 PF16004.5 EGD95950.1 - 5.4e-37 127.1 7.8 9.7e-37 126.3 7.8 1.4 1 0 0 1 1 1 1 116 kDa U5 small nuclear ribonucleoprotein component N-terminus EFG_IV PF03764.18 EGD95950.1 - 3.4e-21 75.2 0.0 1e-20 73.7 0.0 1.9 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_C PF00679.24 EGD95950.1 - 1.5e-19 69.8 0.0 5.1e-19 68.1 0.0 2.0 2 0 0 2 2 2 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 EGD95950.1 - 1.3e-10 41.5 0.0 3.4e-10 40.2 0.0 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_II PF14492.6 EGD95950.1 - 4.1e-07 30.0 0.1 1.2e-06 28.5 0.0 1.8 2 0 0 2 2 2 1 Elongation Factor G, domain II MMR_HSR1 PF01926.23 EGD95950.1 - 1.3e-05 25.2 0.1 2.5e-05 24.3 0.1 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 EGD95950.1 - 0.097 12.1 0.1 1.1 8.7 0.1 2.4 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit DUF5505 PF17610.2 EGD95950.1 - 0.12 12.4 0.1 0.24 11.4 0.1 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5505) Septin PF00735.18 EGD95950.1 - 0.16 11.2 0.0 0.32 10.2 0.0 1.4 1 0 0 1 1 1 0 Septin Chromate_transp PF02417.15 EGD95951.1 - 7.4e-60 201.6 35.9 5.9e-35 120.7 13.8 2.5 3 0 0 3 3 3 2 Chromate transporter adh_short_C2 PF13561.6 EGD95952.1 - 9.1e-48 162.8 1.7 2e-47 161.7 1.7 1.5 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EGD95952.1 - 6.2e-38 130.2 0.4 1.6e-37 128.9 0.4 1.6 1 1 0 1 1 1 1 short chain dehydrogenase Epimerase PF01370.21 EGD95952.1 - 1.1e-06 28.2 0.3 3e-05 23.6 0.0 2.4 2 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family Sacchrp_dh_NADP PF03435.18 EGD95952.1 - 9.4e-05 22.7 0.0 0.00019 21.7 0.0 1.5 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain GDP_Man_Dehyd PF16363.5 EGD95952.1 - 0.00019 20.9 0.1 0.0058 16.1 0.0 2.1 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase TrkA_N PF02254.18 EGD95952.1 - 0.0016 18.7 0.0 0.0035 17.6 0.0 1.6 1 0 0 1 1 1 1 TrkA-N domain KR PF08659.10 EGD95952.1 - 0.0024 17.8 1.9 0.0026 17.7 0.6 2.0 2 1 0 2 2 2 1 KR domain Polysacc_synt_2 PF02719.15 EGD95952.1 - 0.027 13.6 0.0 0.04 13.1 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein F420_oxidored PF03807.17 EGD95952.1 - 0.043 14.4 0.0 0.098 13.2 0.0 1.6 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent 3Beta_HSD PF01073.19 EGD95952.1 - 0.16 10.9 0.1 0.24 10.4 0.1 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family FeS_assembly_P PF01883.19 EGD95953.1 - 1.7e-10 40.9 0.0 4.5e-10 39.6 0.0 1.8 1 1 0 1 1 1 1 Iron-sulfur cluster assembly protein Fungal_trans PF04082.18 EGD95954.1 - 7.2e-08 31.8 0.6 1.5e-07 30.8 0.0 1.7 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EGD95954.1 - 2.6e-05 24.3 7.9 4.5e-05 23.5 7.9 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain RRF PF01765.19 EGD95956.1 - 1.9e-46 158.0 1.4 2.7e-46 157.5 1.4 1.2 1 0 0 1 1 1 1 Ribosome recycling factor Guanylate_kin PF00625.21 EGD95956.1 - 0.036 13.7 0.0 0.11 12.1 0.0 1.8 2 0 0 2 2 2 0 Guanylate kinase FliG_N PF14842.6 EGD95956.1 - 0.068 13.7 0.7 0.2 12.2 0.4 2.0 2 1 1 3 3 3 0 FliG N-terminal domain DUF3813 PF12758.7 EGD95956.1 - 0.9 9.9 4.1 3.5 8.0 1.6 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3813) HSP70 PF00012.20 EGD95957.1 - 8.9e-227 754.0 8.2 1e-226 753.9 8.2 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EGD95957.1 - 6.9e-16 58.0 0.6 4.6e-15 55.3 0.3 2.0 2 0 0 2 2 2 1 MreB/Mbl protein FGGY_C PF02782.16 EGD95957.1 - 9.9e-05 22.1 0.0 0.00021 21.1 0.0 1.5 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain DDR PF08841.10 EGD95957.1 - 0.03 13.3 0.1 0.39 9.7 0.1 2.2 2 0 0 2 2 2 0 Diol dehydratase reactivase ATPase-like domain DevR PF01905.16 EGD95957.1 - 0.086 11.9 0.0 0.15 11.1 0.0 1.3 1 0 0 1 1 1 0 CRISPR-associated negative auto-regulator DevR/Csa2 MscS_porin PF12795.7 EGD95957.1 - 0.29 10.7 2.8 0.18 11.3 0.4 1.8 2 0 0 2 2 2 0 Mechanosensitive ion channel porin domain Bromodomain PF00439.25 EGD95958.1 - 4.9e-29 100.2 1.9 3.9e-16 58.9 0.1 3.3 3 0 0 3 3 3 2 Bromodomain QRPTase_C PF01729.19 EGD95958.1 - 0.017 14.9 0.0 0.036 13.8 0.0 1.5 1 0 0 1 1 1 0 Quinolinate phosphoribosyl transferase, C-terminal domain Trypan_PARP PF05887.11 EGD95958.1 - 6.1 6.8 33.1 1.9 8.5 16.4 2.9 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) CKS PF01111.19 EGD95959.1 - 3e-34 117.1 1.4 3e-34 117.1 1.4 1.4 2 0 0 2 2 2 1 Cyclin-dependent kinase regulatory subunit Thioredoxin_4 PF13462.6 EGD95960.1 - 5.2e-11 43.0 0.1 7.7e-10 39.2 0.1 2.0 1 1 0 1 1 1 1 Thioredoxin UPF0020 PF01170.18 EGD95960.1 - 0.048 13.3 0.1 0.087 12.5 0.1 1.4 1 1 0 1 1 1 0 Putative RNA methylase family UPF0020 DSBA PF01323.20 EGD95960.1 - 0.33 10.7 4.1 0.89 9.3 0.2 2.5 1 1 1 2 2 2 0 DSBA-like thioredoxin domain DUF3844 PF12955.7 EGD95962.1 - 3.3e-36 123.6 4.3 5.7e-36 122.8 4.3 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3844) zf-RING_2 PF13639.6 EGD95963.1 - 2.5e-12 46.9 6.7 3.9e-12 46.3 6.7 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EGD95963.1 - 9.7e-09 34.9 5.9 1.6e-08 34.2 5.9 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EGD95963.1 - 1.6e-08 34.1 1.5 2.9e-08 33.3 1.5 1.5 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4 PF00097.25 EGD95963.1 - 3.7e-08 33.1 4.0 6.1e-08 32.4 4.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EGD95963.1 - 2.7e-06 27.2 3.5 4.4e-06 26.5 3.5 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-rbx1 PF12678.7 EGD95963.1 - 5.1e-06 26.7 10.0 2.5e-05 24.5 10.0 2.0 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 EGD95963.1 - 0.00018 21.4 0.9 0.00018 21.4 0.9 2.3 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 EGD95963.1 - 0.0012 18.6 2.6 0.0021 17.9 2.6 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 EGD95963.1 - 0.0029 17.6 3.2 0.0079 16.2 3.2 1.7 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.5 EGD95963.1 - 0.015 14.9 4.1 0.029 14.0 4.1 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type OAD_gamma PF04277.13 EGD95963.1 - 0.039 14.5 0.0 0.24 12.0 0.0 2.1 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain zf-RING_4 PF14570.6 EGD95963.1 - 0.092 12.6 5.9 0.17 11.7 5.9 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain PHD PF00628.29 EGD95963.1 - 0.11 12.4 5.8 0.23 11.4 5.8 1.6 1 0 0 1 1 1 0 PHD-finger zf-C3HC4_4 PF15227.6 EGD95963.1 - 0.19 11.9 4.9 0.4 10.9 4.9 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 EGD95963.1 - 0.33 10.9 6.1 1.1 9.2 6.1 1.8 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 RINGv PF12906.7 EGD95963.1 - 0.55 10.4 4.0 1.5 9.0 4.0 1.8 1 1 0 1 1 1 0 RING-variant domain FANCL_C PF11793.8 EGD95963.1 - 0.55 10.4 3.7 1.8 8.8 3.7 1.9 1 1 0 1 1 1 0 FANCL C-terminal domain zf-C3H2C3 PF17122.5 EGD95963.1 - 1 9.4 4.9 2.7 8.1 4.9 1.7 1 1 0 1 1 1 0 Zinc-finger Prok-RING_1 PF14446.6 EGD95963.1 - 2.5 8.1 8.1 0.15 12.0 1.4 2.1 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 Pro_isomerase PF00160.21 EGD95965.1 - 9.3e-51 172.2 0.5 1.1e-50 172.0 0.5 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD tRNA-synt_2c PF01411.19 EGD95966.1 - 5.8e-218 724.9 0.0 9.1e-218 724.2 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class II (A) tRNA_SAD PF07973.14 EGD95966.1 - 5e-18 64.9 0.6 1.3e-17 63.5 0.6 1.8 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain DHHA1 PF02272.19 EGD95966.1 - 1.9e-14 54.2 1.3 1.9e-14 54.2 1.3 2.2 2 0 0 2 2 2 1 DHHA1 domain DUF3752 PF12572.8 EGD95968.1 - 1.6e-46 158.6 13.9 1.6e-46 158.6 13.9 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF3752) JHY PF15261.6 EGD95968.1 - 1.4 9.6 12.7 0.14 12.8 7.5 2.0 2 0 0 2 2 2 0 Jhy protein Peptidase_S10 PF00450.22 EGD95969.1 - 3.3e-81 273.8 0.0 4.3e-81 273.5 0.0 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase PHO4 PF01384.20 EGD95970.1 - 0.088 11.8 3.7 0.12 11.4 3.7 1.1 1 0 0 1 1 1 0 Phosphate transporter family Peptidase_S8 PF00082.22 EGD95971.1 - 2.9e-31 108.9 1.3 4.5e-31 108.2 1.3 1.3 1 0 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 EGD95971.1 - 5.2e-13 49.5 0.0 8.3e-13 48.8 0.0 1.3 1 0 0 1 1 1 1 Peptidase inhibitor I9 Rap_GAP PF02145.15 EGD95971.1 - 0.053 13.1 0.0 0.44 10.1 0.0 2.0 2 0 0 2 2 2 0 Rap/ran-GAP TBPIP_N PF15517.6 EGD95971.1 - 0.16 12.0 0.0 0.35 10.9 0.0 1.5 1 0 0 1 1 1 0 TBP-interacting protein N-terminus MIP PF00230.20 EGD95973.1 - 4.9e-58 196.5 3.8 6.3e-58 196.2 3.8 1.1 1 0 0 1 1 1 1 Major intrinsic protein DUF2644 PF10841.8 EGD95973.1 - 1.8 8.8 5.3 0.91 9.8 0.1 3.0 4 0 0 4 4 4 0 Protein of unknown function (DUF2644) FGGY_C PF02782.16 EGD95974.1 - 1.3e-70 237.2 1.5 1.5e-70 237.0 0.6 1.6 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.21 EGD95974.1 - 8e-68 228.6 0.0 1.1e-67 228.1 0.0 1.2 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain APH PF01636.23 EGD95975.1 - 0.075 12.9 0.0 0.14 12.1 0.0 1.5 1 1 0 1 1 1 0 Phosphotransferase enzyme family Pkinase PF00069.25 EGD95976.1 - 4.3e-27 95.1 0.0 2.2e-26 92.8 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD95976.1 - 3e-14 53.0 0.0 6.5e-14 51.8 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EGD95976.1 - 0.0033 16.3 0.0 0.064 12.0 0.0 2.1 2 0 0 2 2 2 1 Fungal protein kinase A_deaminase PF00962.22 EGD95977.1 - 6.2e-123 410.3 0.0 8.2e-123 409.9 0.0 1.2 1 0 0 1 1 1 1 Adenosine/AMP deaminase Abhydrolase_6 PF12697.7 EGD95979.1 - 2.3e-21 77.4 0.1 2.9e-21 77.1 0.1 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EGD95979.1 - 0.027 13.7 0.0 0.053 12.8 0.0 1.6 2 0 0 2 2 2 0 Serine aminopeptidase, S33 PGAP1 PF07819.13 EGD95979.1 - 0.037 13.7 0.0 0.099 12.3 0.0 1.6 2 0 0 2 2 2 0 PGAP1-like protein Peptidase_S9 PF00326.21 EGD95979.1 - 0.041 13.4 0.0 0.07 12.6 0.0 1.3 1 0 0 1 1 1 0 Prolyl oligopeptidase family Frigida PF07899.11 EGD95979.1 - 0.099 11.9 0.0 0.14 11.4 0.0 1.1 1 0 0 1 1 1 0 Frigida-like protein Abhydrolase_8 PF06259.12 EGD95979.1 - 0.14 11.8 0.0 0.24 11.0 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase Abhydrolase_5 PF12695.7 EGD95979.1 - 0.2 11.4 0.0 0.36 10.6 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family VirB8 PF04335.13 EGD95979.1 - 0.24 11.2 0.0 0.39 10.5 0.0 1.2 1 0 0 1 1 1 0 VirB8 protein F-box PF00646.33 EGD95981.1 - 0.00011 22.0 0.0 0.00025 20.8 0.0 1.5 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EGD95981.1 - 0.00027 20.8 0.0 0.0007 19.4 0.0 1.6 1 0 0 1 1 1 1 F-box-like RNase_P_p30 PF01876.16 EGD95982.1 - 5.8e-66 222.0 0.0 7.2e-66 221.7 0.0 1.1 1 0 0 1 1 1 1 RNase P subunit p30 p450 PF00067.22 EGD95983.1 - 0.059 12.1 0.0 0.15 10.8 0.0 1.8 1 1 0 1 1 1 0 Cytochrome P450 ApbA_C PF08546.11 EGD95983.1 - 0.17 12.1 0.0 0.37 11.0 0.0 1.6 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA C terminal EamA PF00892.20 EGD95983.1 - 0.42 10.8 6.1 4.1 7.6 1.7 2.3 2 0 0 2 2 2 0 EamA-like transporter family NmrA PF05368.13 EGD95984.1 - 5.4e-16 58.9 0.1 1.1e-15 57.9 0.1 1.5 1 1 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EGD95984.1 - 1.3e-08 35.0 0.0 2.3e-08 34.1 0.0 1.5 1 0 0 1 1 1 1 NAD(P)H-binding MFS_1 PF07690.16 EGD95985.1 - 3.1e-29 102.0 72.6 3e-26 92.2 44.4 3.4 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EGD95985.1 - 5.1e-10 38.8 6.2 5.1e-10 38.8 6.2 2.5 2 1 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.13 EGD95985.1 - 0.00021 19.9 11.2 0.00035 19.1 11.1 1.5 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) DUF3493 PF11998.8 EGD95985.1 - 0.91 9.7 7.2 1.5 9.0 1.0 3.9 4 0 0 4 4 4 0 Low psii accumulation1 / Rep27 DUF4235 PF14019.6 EGD95985.1 - 1.1 9.4 5.9 2.8 8.1 0.0 3.6 4 0 0 4 4 4 0 Protein of unknown function (DUF4235) Peptidase_M56 PF05569.11 EGD95986.1 - 1.1 8.4 6.5 0.25 10.5 2.1 1.9 1 1 1 2 2 2 0 BlaR1 peptidase M56 p450 PF00067.22 EGD95987.1 - 1.8e-59 201.8 0.0 2.4e-59 201.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Methyltransf_2 PF00891.18 EGD95988.1 - 2.1e-20 72.9 0.0 3e-20 72.4 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain Dimerisation2 PF16864.5 EGD95988.1 - 0.00034 20.5 0.1 0.00087 19.2 0.0 1.7 2 0 0 2 2 2 1 Dimerisation domain Dimerisation PF08100.11 EGD95988.1 - 0.012 15.6 0.0 0.051 13.6 0.0 2.2 1 0 0 1 1 1 0 Dimerisation domain AMP-binding PF00501.28 EGD95989.1 - 1.6e-49 168.7 0.0 2.2e-49 168.2 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme Thioesterase PF00975.20 EGD95989.1 - 5.6e-27 95.3 0.1 3.3e-26 92.8 0.1 2.2 2 1 0 2 2 2 1 Thioesterase domain PP-binding PF00550.25 EGD95989.1 - 3.4e-10 40.1 0.1 9e-10 38.8 0.0 1.8 2 0 0 2 2 2 1 Phosphopantetheine attachment site Abhydrolase_1 PF00561.20 EGD95989.1 - 5.3e-06 26.3 0.0 9.1e-06 25.5 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EGD95989.1 - 0.00013 21.3 0.0 0.00027 20.3 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EGD95989.1 - 0.00023 21.9 0.2 0.00045 20.9 0.2 1.6 1 0 0 1 1 1 1 Alpha/beta hydrolase family Methyltransf_2 PF00891.18 EGD95990.1 - 4.1e-24 85.0 0.0 5.7e-24 84.6 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_25 PF13649.6 EGD95990.1 - 0.007 17.0 0.0 0.016 15.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EGD95990.1 - 0.017 15.7 0.0 0.034 14.8 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Pkinase PF00069.25 EGD95991.1 - 4.6e-65 219.6 0.0 5.4e-65 219.4 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD95991.1 - 2.1e-19 69.8 0.0 2.9e-19 69.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EGD95991.1 - 6.4e-09 36.1 0.7 0.00012 22.0 0.1 2.6 2 1 1 3 3 3 2 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EGD95991.1 - 0.0033 16.3 0.1 0.008 15.0 0.0 1.6 2 0 0 2 2 2 1 Fungal protein kinase Kdo PF06293.14 EGD95991.1 - 0.029 13.7 0.0 0.045 13.1 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EGD95991.1 - 0.03 13.6 0.0 0.052 12.9 0.0 1.4 1 1 0 1 1 1 0 Kinase-like Choline_kinase PF01633.20 EGD95991.1 - 0.041 13.5 1.1 0.06 12.9 0.1 1.8 2 0 0 2 2 2 0 Choline/ethanolamine kinase Pkinase PF00069.25 EGD95992.1 - 8.6e-17 61.4 0.0 2.2e-16 60.0 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD95992.1 - 0.0003 20.2 0.0 0.00044 19.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase BRO1 PF03097.18 EGD95993.1 - 0.082 11.7 0.0 0.084 11.7 0.0 1.1 1 0 0 1 1 1 0 BRO1-like domain TPR_12 PF13424.6 EGD95994.1 - 0.07 13.4 0.0 0.37 11.1 0.0 2.2 1 0 0 1 1 1 0 Tetratricopeptide repeat tRNA-synt_1 PF00133.22 EGD95996.1 - 3.4e-221 735.7 0.3 3.6e-220 732.3 0.3 2.0 1 1 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 EGD95996.1 - 8e-34 116.8 0.5 8e-34 116.8 0.5 2.4 2 0 0 2 2 2 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 EGD95996.1 - 8.6e-15 54.4 0.7 2.7e-07 29.7 0.0 4.5 3 2 1 4 4 4 3 tRNA synthetases class I (M) tRNA-synt_1_2 PF13603.6 EGD95996.1 - 3.8e-09 36.3 4.0 5.8e-06 25.9 0.0 2.9 2 1 1 3 3 3 2 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1e PF01406.19 EGD95996.1 - 0.0024 17.3 0.1 0.3 10.4 0.0 2.6 3 0 0 3 3 3 2 tRNA synthetases class I (C) catalytic domain PepSY PF03413.19 EGD95996.1 - 0.033 14.8 1.9 0.16 12.5 0.0 2.8 2 0 0 2 2 2 0 Peptidase propeptide and YPEB domain DnaJ PF00226.31 EGD95998.1 - 1.1e-20 73.6 0.5 3.6e-20 71.8 0.5 2.0 1 0 0 1 1 1 1 DnaJ domain Trypan_PARP PF05887.11 EGD95998.1 - 0.00013 21.9 15.9 0.00013 21.9 15.9 2.3 2 1 0 2 2 2 1 Procyclic acidic repetitive protein (PARP) zf-B_box PF00643.24 EGD95998.1 - 0.029 14.5 1.9 0.056 13.6 1.9 1.4 1 0 0 1 1 1 0 B-box zinc finger Zn_ribbon_17 PF17120.5 EGD95998.1 - 0.038 13.6 2.1 0.064 12.9 2.1 1.3 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type FYVE PF01363.21 EGD95998.1 - 0.5 10.6 5.1 0.53 10.5 3.5 1.9 2 0 0 2 2 2 0 FYVE zinc finger DUF116 PF01976.17 EGD95999.1 - 0.13 11.8 0.2 0.21 11.1 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function DUF116 DUF3431 PF11913.8 EGD96000.1 - 3.2e-83 278.8 0.0 4.4e-83 278.3 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3431) SurE PF01975.17 EGD96002.1 - 7.4e-36 123.8 0.1 9.8e-36 123.4 0.1 1.1 1 0 0 1 1 1 1 Survival protein SurE zf-rbx1 PF12678.7 EGD96003.1 - 4.9e-09 36.3 3.1 1.1e-08 35.2 3.1 1.7 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 EGD96003.1 - 1.8e-07 31.4 2.8 1.8e-07 31.4 2.8 2.1 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4 PF00097.25 EGD96003.1 - 2.3e-07 30.5 0.2 5.1e-07 29.5 0.2 1.6 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EGD96003.1 - 8.2e-06 25.6 5.6 4e-05 23.4 1.8 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EGD96003.1 - 5.1e-05 23.2 0.8 0.00011 22.2 0.8 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 EGD96003.1 - 0.00013 21.7 3.1 0.00013 21.7 3.1 1.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EGD96003.1 - 0.00028 20.8 1.5 0.0017 18.3 0.4 2.1 2 0 0 2 2 2 1 zinc-RING finger domain Zn_ribbon_17 PF17120.5 EGD96003.1 - 0.00064 19.3 0.7 0.0013 18.4 0.7 1.4 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type Prok-RING_4 PF14447.6 EGD96003.1 - 0.0035 17.2 0.8 0.0035 17.2 0.8 1.7 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 EGD96003.1 - 0.0041 17.1 5.0 0.066 13.3 5.0 2.2 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger YacG PF03884.14 EGD96003.1 - 0.02 14.6 0.4 0.056 13.2 0.4 1.8 1 0 0 1 1 1 0 DNA gyrase inhibitor YacG zf-RING_11 PF17123.5 EGD96003.1 - 0.2 11.5 2.5 0.78 9.5 0.2 2.4 2 0 0 2 2 2 0 RING-like zinc finger MCM_bind PF09739.9 EGD96003.1 - 1.7 7.0 4.1 2.8 6.3 4.1 1.2 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor NOA36 PF06524.12 EGD96003.1 - 2 7.6 14.0 4.5 6.5 14.0 1.5 1 0 0 1 1 1 0 NOA36 protein zf-RING_4 PF14570.6 EGD96003.1 - 3 7.7 4.4 1.1 9.1 1.4 1.7 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain MFS_1 PF07690.16 EGD96004.1 - 9e-21 74.2 35.8 4.6e-11 42.2 7.2 3.1 3 0 0 3 3 3 3 Major Facilitator Superfamily ATG22 PF11700.8 EGD96004.1 - 2.9e-07 29.5 1.3 2e-05 23.4 0.0 2.9 2 1 1 3 3 3 3 Vacuole effluxer Atg22 like MFS_1_like PF12832.7 EGD96004.1 - 8.5e-07 28.2 6.1 0.0069 15.3 0.1 3.3 3 0 0 3 3 3 3 MFS_1 like family MFS_2 PF13347.6 EGD96004.1 - 9.4e-05 21.1 6.0 9.4e-05 21.1 6.0 3.2 3 0 0 3 3 3 2 MFS/sugar transport protein LacY_symp PF01306.19 EGD96004.1 - 0.018 13.8 11.9 0.033 13.0 1.9 3.2 3 0 0 3 3 3 0 LacY proton/sugar symporter Myb_DNA-bind_4 PF13837.6 EGD96005.1 - 0.048 14.0 0.1 0.12 12.7 0.1 1.7 1 0 0 1 1 1 0 Myb/SANT-like DNA-binding domain ATP_transf PF09830.9 EGD96006.1 - 1.5e-23 82.7 0.2 2.6e-23 81.9 0.2 1.4 1 0 0 1 1 1 1 ATP adenylyltransferase HIT PF01230.23 EGD96006.1 - 0.056 14.2 0.1 0.12 13.1 0.1 1.6 1 0 0 1 1 1 0 HIT domain E1_4HB PF16191.5 EGD96006.1 - 0.099 12.8 0.5 0.26 11.5 0.1 1.9 2 0 0 2 2 2 0 Ubiquitin-activating enzyme E1 four-helix bundle DUF4931 PF16285.5 EGD96006.1 - 0.1 11.9 0.0 0.22 10.8 0.0 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4931) zf-C2H2 PF00096.26 EGD96007.1 - 0.00015 22.1 16.8 1.5 9.4 0.1 5.0 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EGD96007.1 - 0.69 10.9 19.7 4.7 8.3 0.1 5.1 5 1 0 5 5 5 0 C2H2-type zinc finger RPN7 PF10602.9 EGD96008.1 - 1.8e-50 171.0 0.1 3.1e-50 170.3 0.1 1.4 1 0 0 1 1 1 1 26S proteasome subunit RPN7 PCI PF01399.27 EGD96008.1 - 2.7e-10 40.7 0.1 8e-10 39.2 0.1 1.8 1 0 0 1 1 1 1 PCI domain DSBA PF01323.20 EGD96009.1 - 1.6e-18 67.2 0.0 1.8e-18 67.0 0.0 1.0 1 0 0 1 1 1 1 DSBA-like thioredoxin domain adh_short PF00106.25 EGD96010.1 - 6.3e-28 97.6 0.6 2.7e-18 66.1 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EGD96010.1 - 2e-20 73.4 0.1 1.9e-18 66.9 0.1 2.1 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EGD96010.1 - 3.8e-05 23.7 0.0 5.9e-05 23.1 0.0 1.2 1 0 0 1 1 1 1 KR domain LtrA PF06772.11 EGD96011.1 - 1.5e-21 77.0 20.6 1.5e-21 77.0 20.6 2.1 2 0 0 2 2 2 2 Bacterial low temperature requirement A protein (LtrA) OrfB_IS605 PF01385.19 EGD96012.1 - 0.4 10.9 2.9 8.8 6.6 0.1 2.8 1 1 1 2 2 2 0 Probable transposase Nup54 PF13874.6 EGD96012.1 - 0.43 10.7 7.7 0.37 10.9 1.4 2.4 2 0 0 2 2 2 0 Nucleoporin complex subunit 54 zf-C4H2 PF10146.9 EGD96012.1 - 5.2 7.3 12.4 0.041 14.2 2.5 2.3 2 1 0 2 2 2 0 Zinc finger-containing protein LSM PF01423.22 EGD96013.1 - 5.3e-23 80.5 0.5 5.9e-23 80.4 0.5 1.0 1 0 0 1 1 1 1 LSM domain Peptidase_M1_N PF17900.1 EGD96014.1 - 0.0029 17.8 0.1 2.9 8.0 0.0 2.6 2 0 0 2 2 2 2 Peptidase M1 N-terminal domain CDP-OH_P_transf PF01066.21 EGD96015.1 - 9.3e-16 58.4 0.0 9.3e-16 58.4 0.0 2.8 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase PALP PF00291.25 EGD96016.1 - 2.1e-37 129.1 0.1 2.6e-37 128.8 0.1 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme DUF4187 PF13821.6 EGD96017.1 - 3.7e-21 74.7 0.9 3.7e-21 74.7 0.9 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF4187) G-patch PF01585.23 EGD96017.1 - 2.1e-10 40.3 1.9 1.2e-08 34.7 1.9 3.0 2 1 0 2 2 2 1 G-patch domain FAM60A PF15396.6 EGD96017.1 - 1.7 8.6 7.6 0.19 11.7 1.1 2.2 2 0 0 2 2 2 0 Protein Family FAM60A SPX PF03105.19 EGD96018.1 - 0.011 15.7 6.2 0.013 15.4 6.2 1.2 1 0 0 1 1 1 0 SPX domain CPSase_L_D2 PF02786.17 EGD96021.1 - 8.9e-107 355.4 0.0 2e-83 279.0 0.0 2.2 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_L_D3 PF02787.19 EGD96021.1 - 1.7e-41 141.4 0.1 4.3e-41 140.1 0.1 1.7 1 0 0 1 1 1 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain ATP-grasp PF02222.22 EGD96021.1 - 1.6e-17 63.6 0.0 1.7e-07 31.0 0.0 2.3 2 0 0 2 2 2 2 ATP-grasp domain Dala_Dala_lig_C PF07478.13 EGD96021.1 - 9.5e-16 57.9 0.1 7.7e-07 28.8 0.0 2.4 2 0 0 2 2 2 2 D-ala D-ala ligase C-terminus ATPgrasp_Ter PF15632.6 EGD96021.1 - 5.5e-10 39.1 0.0 0.0013 18.5 0.0 3.0 2 1 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon RimK PF08443.11 EGD96021.1 - 2e-05 24.2 0.0 0.041 13.5 0.0 2.5 2 0 0 2 2 2 2 RimK-like ATP-grasp domain ATP-grasp_5 PF13549.6 EGD96021.1 - 0.00013 21.5 0.0 0.024 14.1 0.0 2.4 2 0 0 2 2 2 2 ATP-grasp domain GARS_A PF01071.19 EGD96021.1 - 0.00045 20.0 0.0 0.062 13.1 0.0 2.5 2 0 0 2 2 2 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain Pkinase PF00069.25 EGD96023.1 - 6.5e-09 35.5 0.0 1.2e-08 34.6 0.0 1.4 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD96023.1 - 4.6e-07 29.4 0.0 7e-07 28.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EGD96023.1 - 0.0023 17.9 0.0 0.0033 17.4 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.22 EGD96023.1 - 0.0096 15.5 0.0 0.013 15.2 0.0 1.1 1 0 0 1 1 1 1 RIO1 family FAM178 PF14816.6 EGD96023.1 - 0.023 13.7 0.0 0.03 13.3 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function, FAM178 Kdo PF06293.14 EGD96023.1 - 0.028 13.8 0.0 0.041 13.2 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EGD96023.1 - 0.058 12.7 0.0 0.074 12.4 0.0 1.1 1 0 0 1 1 1 0 Kinase-like Choline_kinase PF01633.20 EGD96023.1 - 0.067 12.8 0.0 0.098 12.2 0.0 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase SET PF00856.28 EGD96024.1 - 7.6e-15 55.7 0.2 6.6e-14 52.6 0.1 2.2 2 0 0 2 2 2 1 SET domain zf-MYND PF01753.18 EGD96024.1 - 4.5e-10 39.5 6.6 4.5e-10 39.5 6.6 2.1 2 0 0 2 2 2 1 MYND finger V-ATPase_G PF03179.15 EGD96024.1 - 2.6 8.6 5.6 0.51 10.9 1.8 1.8 2 0 0 2 2 2 0 Vacuolar (H+)-ATPase G subunit Ribosomal_S19 PF00203.21 EGD96025.1 - 8.7e-33 112.1 0.3 1.2e-32 111.6 0.3 1.2 1 0 0 1 1 1 1 Ribosomal protein S19 Ribosomal_60s PF00428.19 EGD96026.1 - 2.1e-26 92.3 8.2 2.5e-26 92.1 8.2 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein Sigma70_r1_1 PF03979.14 EGD96026.1 - 0.54 10.4 0.1 0.54 10.4 0.1 2.1 2 0 0 2 2 2 0 Sigma-70 factor, region 1.1 SPT2 PF08243.11 EGD96027.1 - 8.6e-12 45.6 11.5 8.6e-12 45.6 11.5 2.3 2 0 0 2 2 2 1 SPT2 chromatin protein Carb_kinase PF01256.17 EGD96028.1 - 6.4e-56 189.6 0.1 7.7e-55 186.0 0.0 1.9 2 0 0 2 2 2 2 Carbohydrate kinase zf-C2H2 PF00096.26 EGD96029.1 - 0.0082 16.6 40.7 0.017 15.5 0.7 6.5 6 0 0 6 6 6 3 Zinc finger, C2H2 type zf-C2H2_8 PF15909.5 EGD96029.1 - 0.74 10.2 13.7 0.13 12.6 0.7 3.3 3 1 0 3 3 3 0 C2H2-type zinc ribbon zf-C2H2_jaz PF12171.8 EGD96029.1 - 1.6 9.1 16.8 2.3 8.6 1.5 4.5 5 0 0 5 5 5 0 Zinc-finger double-stranded RNA-binding zf-C2H2_aberr PF17017.5 EGD96029.1 - 7.1 6.7 7.7 0.88 9.7 0.5 2.8 2 1 1 3 3 3 0 Aberrant zinc-finger Peptidase_S8 PF00082.22 EGD96030.1 - 6.3e-25 88.0 6.8 9.1e-25 87.5 5.6 1.9 1 1 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 EGD96030.1 - 1.6e-13 51.1 0.3 2.9e-13 50.3 0.3 1.3 1 0 0 1 1 1 1 Peptidase inhibitor I9 CLN3 PF02487.17 EGD96030.1 - 0.14 11.2 0.0 0.21 10.6 0.0 1.2 1 0 0 1 1 1 0 CLN3 protein OEP PF02321.18 EGD96031.1 - 0.00047 20.0 3.0 0.001 18.9 3.0 1.5 1 0 0 1 1 1 1 Outer membrane efflux protein zf-C2H2 PF00096.26 EGD96031.1 - 0.0029 18.0 26.0 0.09 13.3 0.5 4.7 4 0 0 4 4 4 3 Zinc finger, C2H2 type FOXP-CC PF16159.5 EGD96031.1 - 0.016 15.8 1.5 0.016 15.8 1.5 3.8 3 1 1 4 4 4 0 FOXP coiled-coil domain PapD_N PF00345.20 EGD96031.1 - 0.056 13.4 0.4 0.16 11.9 0.1 1.9 2 0 0 2 2 2 0 Pili and flagellar-assembly chaperone, PapD N-terminal domain Filament PF00038.21 EGD96032.1 - 0.00083 19.0 47.4 0.00083 19.0 47.4 3.6 2 1 1 3 3 3 1 Intermediate filament protein Methyltransf_16 PF10294.9 EGD96034.1 - 0.031 14.0 0.0 1.9 8.2 0.0 2.4 2 0 0 2 2 2 0 Lysine methyltransferase Peptidase_M36 PF02128.15 EGD96035.1 - 1.7e-158 527.6 5.5 2.2e-158 527.3 5.5 1.1 1 0 0 1 1 1 1 Fungalysin metallopeptidase (M36) FTP PF07504.13 EGD96035.1 - 1.4e-16 60.0 1.5 3.1e-16 58.9 1.5 1.5 1 0 0 1 1 1 1 Fungalysin/Thermolysin Propeptide Motif Peptidase_M4_C PF02868.15 EGD96035.1 - 0.074 12.9 0.0 0.21 11.5 0.0 1.8 1 0 0 1 1 1 0 Thermolysin metallopeptidase, alpha-helical domain Cys_Met_Meta_PP PF01053.20 EGD96036.1 - 1.9e-129 431.6 0.0 2.3e-129 431.3 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 EGD96036.1 - 8.6e-06 25.2 0.0 1.3e-05 24.6 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 EGD96036.1 - 0.0049 16.2 0.6 0.012 14.9 0.6 1.6 1 1 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_5 PF00266.19 EGD96036.1 - 0.0098 14.9 0.1 0.021 13.8 0.1 1.5 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 EGD96036.1 - 0.011 15.0 0.1 0.019 14.2 0.1 1.5 1 1 0 1 1 1 0 Beta-eliminating lyase Crinivirus_P26 PF07416.11 EGD96036.1 - 0.075 12.7 0.0 0.15 11.8 0.0 1.4 1 0 0 1 1 1 0 Crinivirus P26 protein RNA_pol_Rbc25 PF08292.12 EGD96037.1 - 6e-35 120.3 1.1 2.1e-34 118.5 1.1 1.8 1 1 0 1 1 1 1 RNA polymerase III subunit Rpc25 SHS2_Rpb7-N PF03876.17 EGD96037.1 - 2.9e-15 56.4 0.0 4.7e-15 55.7 0.0 1.4 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 NUFIP1 PF10453.9 EGD96038.1 - 7.3e-11 41.7 6.0 7.3e-11 41.7 6.0 4.3 2 1 1 3 3 3 1 Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1) zf-CCCH PF00642.24 EGD96038.1 - 5.7e-07 29.3 5.8 9.3e-07 28.6 5.8 1.4 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 EGD96038.1 - 0.00011 22.1 5.0 0.0002 21.3 5.0 1.4 1 0 0 1 1 1 1 Zinc finger domain AF-4 PF05110.13 EGD96038.1 - 0.00084 17.6 21.6 0.00084 17.6 21.6 2.6 1 1 1 2 2 2 1 AF-4 proto-oncoprotein zf-CCCH_4 PF18044.1 EGD96038.1 - 0.0089 15.8 4.1 0.014 15.2 4.1 1.3 1 0 0 1 1 1 1 CCCH-type zinc finger RRM_1 PF00076.22 EGD96039.1 - 1.1e-10 41.1 0.6 9.6e-07 28.5 0.0 3.1 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Med24_N PF11277.8 EGD96039.1 - 1.7 6.6 4.6 2.3 6.1 4.6 1.1 1 0 0 1 1 1 0 Mediator complex subunit 24 N-terminal APH PF01636.23 EGD96040.1 - 3.4e-08 33.7 0.0 4.7e-08 33.3 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EGD96040.1 - 0.0087 15.7 0.0 0.016 14.8 0.0 1.5 2 0 0 2 2 2 1 Choline/ethanolamine kinase RIO1 PF01163.22 EGD96040.1 - 0.027 14.1 0.0 0.052 13.1 0.0 1.4 1 0 0 1 1 1 0 RIO1 family EcKinase PF02958.20 EGD96040.1 - 0.15 11.3 0.0 0.23 10.7 0.0 1.2 1 0 0 1 1 1 0 Ecdysteroid kinase Sds3 PF08598.11 EGD96042.1 - 4.5e-12 46.4 0.9 4.5e-12 46.4 0.9 2.3 2 1 0 2 2 2 1 Sds3-like DUF4940 PF16298.5 EGD96042.1 - 0.03 14.0 0.1 0.63 9.7 0.1 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4940) Coiled-coil_56 PF09813.9 EGD96044.1 - 0.0024 17.9 0.0 0.0024 17.9 0.0 1.1 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 56 DUF3453 PF11935.8 EGD96045.1 - 2.5e-68 230.1 2.6 2.5e-68 230.1 2.6 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF3453) SMN PF06003.12 EGD96045.1 - 0.099 11.9 2.5 0.2 10.9 2.5 1.5 1 0 0 1 1 1 0 Survival motor neuron protein (SMN) CSN8_PSD8_EIF3K PF10075.9 EGD96046.1 - 4.2e-15 56.0 0.0 6.1e-15 55.5 0.0 1.2 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family PCI PF01399.27 EGD96046.1 - 0.1 13.1 0.0 0.26 11.8 0.0 1.8 1 1 0 1 1 1 0 PCI domain ATP-synt_E PF05680.12 EGD96047.1 - 6.9e-23 80.8 0.2 7.1e-23 80.8 0.2 1.0 1 0 0 1 1 1 1 ATP synthase E chain Drf_GBD PF06371.13 EGD96047.1 - 0.11 12.1 0.0 0.12 11.9 0.0 1.1 1 0 0 1 1 1 0 Diaphanous GTPase-binding Domain WD40 PF00400.32 EGD96048.1 - 0.0002 22.1 11.5 2.2 9.3 0.1 6.1 6 1 0 6 6 6 3 WD domain, G-beta repeat Ribosomal_60s PF00428.19 EGD96049.1 - 1.2 9.8 5.9 0.15 12.7 0.6 2.3 2 0 0 2 2 2 0 60s Acidic ribosomal protein PMT PF02366.18 EGD96050.1 - 4.9e-86 288.3 15.6 7.9e-86 287.6 15.6 1.3 1 0 0 1 1 1 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 EGD96050.1 - 1.9e-59 200.6 1.7 1.9e-59 200.6 1.7 3.1 2 1 1 3 3 3 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 EGD96050.1 - 3.2e-20 72.8 0.3 6.6e-20 71.7 0.3 1.5 1 0 0 1 1 1 1 MIR domain PMT_2 PF13231.6 EGD96050.1 - 0.0044 17.2 3.6 0.0044 17.2 3.6 2.8 3 1 1 4 4 4 1 Dolichyl-phosphate-mannose-protein mannosyltransferase Pirin PF02678.16 EGD96051.1 - 9.5e-30 102.8 0.1 1.9e-29 101.8 0.1 1.5 1 0 0 1 1 1 1 Pirin Pirin_C PF05726.13 EGD96051.1 - 5.3e-25 87.8 0.0 1.6e-24 86.3 0.0 1.8 2 0 0 2 2 2 1 Pirin C-terminal cupin domain Cupin_2 PF07883.11 EGD96051.1 - 0.00011 21.9 1.2 0.0018 18.0 1.0 2.4 2 1 0 2 2 2 1 Cupin domain APH PF01636.23 EGD96052.1 - 1.3e-16 61.3 0.0 2.6e-16 60.3 0.0 1.4 1 1 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 EGD96052.1 - 0.00056 19.3 0.0 0.11 11.8 0.0 2.2 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 EGD96052.1 - 0.0014 18.3 0.0 0.0023 17.5 0.0 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase RIO1 PF01163.22 EGD96052.1 - 0.062 12.9 0.0 0.29 10.7 0.0 1.8 2 0 0 2 2 2 0 RIO1 family Pox_ser-thr_kin PF05445.11 EGD96052.1 - 0.075 12.0 0.0 0.1 11.5 0.0 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase STT3 PF02516.14 EGD96054.1 - 1.4e-147 492.6 33.6 1.8e-141 472.4 33.8 2.4 3 0 0 3 3 3 2 Oligosaccharyl transferase STT3 subunit PRKCSH PF07915.13 EGD96055.1 - 3.6e-18 66.3 0.1 3.6e-18 66.3 0.1 2.9 2 1 0 2 2 2 1 Glucosidase II beta subunit-like protein SHD1 PF03983.12 EGD96056.1 - 1.9e-33 114.1 0.0 3.4e-33 113.3 0.0 1.4 1 0 0 1 1 1 1 SLA1 homology domain 1, SHD1 SH3_1 PF00018.28 EGD96056.1 - 2.9e-32 110.0 4.7 1.8e-11 43.5 0.1 4.4 4 0 0 4 4 4 3 SH3 domain SH3_9 PF14604.6 EGD96056.1 - 5.3e-30 103.0 5.8 2.9e-11 43.1 0.1 4.0 4 0 0 4 4 4 3 Variant SH3 domain SH3_2 PF07653.17 EGD96056.1 - 4.6e-21 74.2 0.4 6.6e-08 32.1 0.0 4.5 4 0 0 4 4 4 4 Variant SH3 domain SAM_4 PF18017.1 EGD96056.1 - 4.4e-05 23.4 0.0 0.00014 21.7 0.0 1.8 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SH3_10 PF17902.1 EGD96056.1 - 0.044 13.8 0.9 2.2 8.4 0.0 3.2 4 0 0 4 4 4 0 SH3 domain HSCB_C PF07743.13 EGD96058.1 - 1.4e-17 63.9 1.7 2.3e-17 63.3 0.5 1.9 2 0 0 2 2 2 1 HSCB C-terminal oligomerisation domain DnaJ PF00226.31 EGD96058.1 - 3.1e-05 24.0 0.1 0.00022 21.3 0.0 2.2 2 0 0 2 2 2 1 DnaJ domain DUF4352 PF11611.8 EGD96058.1 - 0.079 13.2 0.0 0.14 12.5 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4352) 3Beta_HSD PF01073.19 EGD96059.1 - 4.6e-08 32.4 0.1 9.6e-08 31.4 0.0 1.5 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 EGD96059.1 - 3.3e-05 23.5 0.1 0.00011 21.7 0.1 1.8 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 EGD96059.1 - 0.0016 18.4 0.0 0.0028 17.6 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding NAD_binding_4 PF07993.12 EGD96059.1 - 0.023 13.8 0.0 0.15 11.2 0.0 1.9 2 0 0 2 2 2 0 Male sterility protein F-box-like PF12937.7 EGD96060.1 - 0.00027 20.8 0.5 0.00027 20.8 0.5 2.3 2 0 0 2 2 2 1 F-box-like ATP-synt_D PF01813.17 EGD96060.1 - 0.00098 19.0 0.1 0.0019 18.1 0.1 1.4 1 0 0 1 1 1 1 ATP synthase subunit D F-box PF00646.33 EGD96060.1 - 0.023 14.6 1.0 0.023 14.6 1.0 1.9 2 0 0 2 2 2 0 F-box domain WD40 PF00400.32 EGD96061.1 - 2.7e-33 113.5 22.1 2.4e-07 31.3 0.6 7.9 8 0 0 8 8 8 5 WD domain, G-beta repeat PRP4 PF08799.11 EGD96061.1 - 2.2e-14 52.7 0.8 4.2e-14 51.8 0.8 1.5 1 0 0 1 1 1 1 pre-mRNA processing factor 4 (PRP4) like ANAPC4_WD40 PF12894.7 EGD96061.1 - 3e-11 43.5 0.1 0.026 14.8 0.0 5.7 3 1 2 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EGD96061.1 - 0.0079 15.6 0.0 0.31 10.3 0.0 2.6 2 0 0 2 2 2 1 WD40-like domain Nbas_N PF15492.6 EGD96061.1 - 0.073 12.4 0.0 3.6 6.8 0.0 2.5 2 1 1 3 3 3 0 Neuroblastoma-amplified sequence, N terminal SpoIIE PF07228.12 EGD96062.1 - 3.3e-11 43.5 0.1 1.1e-09 38.5 0.1 2.1 2 0 0 2 2 2 1 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.6 EGD96062.1 - 2.9e-07 30.3 0.2 6.9e-07 29.1 0.2 1.6 1 1 0 1 1 1 1 Protein phosphatase 2C PP2C PF00481.21 EGD96062.1 - 4.9e-06 26.4 0.1 0.0024 17.5 0.0 2.2 2 0 0 2 2 2 2 Protein phosphatase 2C ComA PF02679.15 EGD96063.1 - 3.4e-88 295.2 0.0 4e-88 295.0 0.0 1.0 1 0 0 1 1 1 1 (2R)-phospho-3-sulfolactate synthase (ComA) PWWP PF00855.17 EGD96064.1 - 2.2e-15 56.8 7.3 2.2e-15 56.8 7.3 3.7 2 1 0 2 2 2 1 PWWP domain OPT PF03169.15 EGD96065.1 - 6.7e-85 286.0 47.0 7.9e-85 285.7 47.0 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein DUF3632 PF12311.8 EGD96066.1 - 1.5e-11 45.1 0.0 2.2e-11 44.5 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3632) Pkinase PF00069.25 EGD96067.1 - 1.4e-34 119.7 0.0 1.4e-19 70.5 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EGD96067.1 - 1.4e-11 44.2 0.0 5.7e-09 35.6 0.0 2.8 2 1 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 EGD96067.1 - 0.005 16.2 0.0 0.63 9.3 0.0 2.2 2 0 0 2 2 2 2 Kinase-like APH PF01636.23 EGD96067.1 - 0.0086 16.0 0.0 0.016 15.2 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family CAP_GLY PF01302.25 EGD96068.1 - 2e-15 56.5 0.8 4.4e-15 55.4 0.2 1.9 2 0 0 2 2 2 1 CAP-Gly domain CLIP1_ZNF PF16641.5 EGD96068.1 - 1.7e-07 31.0 9.6 4.9e-05 23.1 0.9 2.6 2 0 0 2 2 2 2 CLIP1 zinc knuckle Fez1 PF06818.15 EGD96068.1 - 0.0013 19.3 23.1 0.065 13.7 14.1 3.0 2 1 1 3 3 3 2 Fez1 TolA_bind_tri PF16331.5 EGD96068.1 - 0.011 15.8 2.5 0.011 15.8 2.5 4.0 2 1 0 3 3 3 0 TolA binding protein trimerisation Spc7 PF08317.11 EGD96068.1 - 0.073 11.9 25.8 0.91 8.3 0.2 3.0 2 1 1 3 3 3 0 Spc7 kinetochore protein DUF1664 PF07889.12 EGD96068.1 - 0.16 12.0 14.0 0.36 10.9 2.3 3.4 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) DUF812 PF05667.11 EGD96068.1 - 0.16 10.8 22.6 0.11 11.3 13.2 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF812) AAA_13 PF13166.6 EGD96068.1 - 0.19 10.3 12.1 0.17 10.5 6.1 2.2 2 0 0 2 2 2 0 AAA domain C1_2 PF03107.16 EGD96068.1 - 0.45 10.9 2.1 15 6.0 0.1 2.4 2 0 0 2 2 2 0 C1 domain HMMR_N PF15905.5 EGD96068.1 - 0.6 9.5 25.8 2.6 7.4 0.6 2.6 2 1 0 2 2 2 0 Hyaluronan mediated motility receptor N-terminal EzrA PF06160.12 EGD96068.1 - 0.65 8.1 17.4 0.61 8.2 3.1 3.0 2 1 1 3 3 3 0 Septation ring formation regulator, EzrA GIT_CC PF16559.5 EGD96068.1 - 0.72 9.8 5.9 9.2 6.2 2.1 2.8 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor Sec34 PF04136.15 EGD96068.1 - 1 9.2 8.1 1.6 8.6 2.9 2.3 2 0 0 2 2 2 0 Sec34-like family DUF745 PF05335.13 EGD96068.1 - 1.9 8.1 12.6 0.17 11.6 2.2 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF745) FAM76 PF16046.5 EGD96068.1 - 2.6 7.3 13.7 9 5.6 5.9 2.8 2 1 0 2 2 2 0 FAM76 protein DUF16 PF01519.16 EGD96068.1 - 3 8.4 12.6 2.6 8.6 0.1 3.9 3 1 1 4 4 4 0 Protein of unknown function DUF16 Syntaxin-6_N PF09177.11 EGD96068.1 - 3.4 8.3 12.9 32 5.2 0.0 3.8 2 1 1 3 3 3 0 Syntaxin 6, N-terminal PKcGMP_CC PF16808.5 EGD96068.1 - 4.1 7.3 27.5 0.24 11.3 2.3 4.6 5 0 0 5 5 4 0 Coiled-coil N-terminus of cGMP-dependent protein kinase NPV_P10 PF05531.12 EGD96068.1 - 5.7 7.5 13.6 53 4.4 0.1 4.3 3 1 1 4 4 4 0 Nucleopolyhedrovirus P10 protein FliS PF02561.14 EGD96068.1 - 6.5 7.1 6.9 7.3 6.9 0.6 2.8 3 1 1 4 4 3 0 Flagellar protein FliS 3-HAO PF06052.12 EGD96069.1 - 3.2e-56 189.2 0.0 3.7e-56 189.0 0.0 1.1 1 0 0 1 1 1 1 3-hydroxyanthranilic acid dioxygenase Cupin_2 PF07883.11 EGD96069.1 - 5.7e-05 22.7 0.1 8.3e-05 22.2 0.1 1.3 1 0 0 1 1 1 1 Cupin domain AraC_binding PF02311.19 EGD96069.1 - 0.026 14.4 0.0 0.043 13.7 0.0 1.3 1 0 0 1 1 1 0 AraC-like ligand binding domain RTC_insert PF05189.13 EGD96070.1 - 1.7e-31 108.7 0.0 6.1e-31 107.0 0.0 1.9 2 0 0 2 2 2 1 RNA 3'-terminal phosphate cyclase (RTC), insert domain RTC PF01137.21 EGD96070.1 - 3.6e-19 68.9 0.0 3.1e-18 65.8 0.0 1.9 1 1 0 1 1 1 1 RNA 3'-terminal phosphate cyclase Peptidase_S9 PF00326.21 EGD96072.1 - 7.8e-51 172.6 0.0 1.2e-50 171.9 0.0 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family AXE1 PF05448.12 EGD96072.1 - 0.0002 20.2 0.0 0.052 12.2 0.0 2.2 2 0 0 2 2 2 2 Acetyl xylan esterase (AXE1) DUF3189 PF11385.8 EGD96072.1 - 0.09 12.6 0.0 0.17 11.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3189) Sec63 PF02889.16 EGD96073.1 - 1e-165 549.2 0.1 5.2e-93 310.9 0.0 2.2 2 0 0 2 2 2 2 Sec63 Brl domain DEAD PF00270.29 EGD96073.1 - 3e-46 157.4 0.1 1.6e-27 96.4 0.0 3.2 3 0 0 3 3 3 2 DEAD/DEAH box helicase Helicase_PWI PF18149.1 EGD96073.1 - 2.1e-29 101.9 0.1 5.8e-29 100.5 0.1 1.8 1 0 0 1 1 1 1 N-terminal helicase PWI domain ResIII PF04851.15 EGD96073.1 - 2.8e-22 79.5 0.0 5e-13 49.4 0.0 2.5 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EGD96073.1 - 2e-10 41.0 0.0 1.2e-07 32.1 0.0 3.6 2 2 0 2 2 2 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 EGD96073.1 - 5e-06 26.8 0.1 0.0033 17.7 0.0 3.5 3 0 0 3 3 3 1 AAA domain PhoH PF02562.16 EGD96073.1 - 0.00093 18.7 0.0 0.053 13.0 0.0 2.4 2 0 0 2 2 2 1 PhoH-like protein T2SSE PF00437.20 EGD96073.1 - 0.026 13.6 0.0 1.5 7.8 0.0 2.4 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_19 PF13245.6 EGD96073.1 - 0.056 13.8 0.1 23 5.3 0.0 3.2 3 0 0 3 3 3 0 AAA domain MutS_V PF00488.21 EGD96074.1 - 6.6e-73 244.8 0.0 1.2e-72 243.9 0.0 1.4 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 EGD96074.1 - 1.6e-43 149.2 2.8 1.6e-43 149.2 2.8 1.8 2 0 0 2 2 2 1 MutS domain III MutS_I PF01624.20 EGD96074.1 - 1e-14 54.7 0.0 2.6e-14 53.4 0.0 1.7 1 0 0 1 1 1 1 MutS domain I MutS_II PF05188.17 EGD96074.1 - 2.6e-09 37.5 0.0 7.4e-09 36.0 0.0 1.7 1 0 0 1 1 1 1 MutS domain II AAA_29 PF13555.6 EGD96074.1 - 0.038 13.7 0.0 0.1 12.3 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_27 PF13514.6 EGD96074.1 - 0.046 13.3 0.1 0.31 10.6 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.6 EGD96074.1 - 0.047 14.2 1.5 0.31 11.5 0.0 2.5 2 1 0 2 2 2 0 AAA domain AAA_14 PF13173.6 EGD96074.1 - 0.063 13.3 0.0 0.21 11.6 0.0 1.9 1 0 0 1 1 1 0 AAA domain Ureidogly_lyase PF04115.12 EGD96075.1 - 3.8e-57 193.1 0.0 4.5e-57 192.8 0.0 1.0 1 0 0 1 1 1 1 Ureidoglycolate lyase Catalase PF00199.19 EGD96076.1 - 5.9e-195 647.8 0.0 7.4e-195 647.4 0.0 1.0 1 0 0 1 1 1 1 Catalase Catalase-rel PF06628.12 EGD96076.1 - 5e-12 45.9 0.0 1.2e-11 44.6 0.0 1.7 1 0 0 1 1 1 1 Catalase-related immune-responsive Rer1 PF03248.13 EGD96077.1 - 1.4e-73 246.3 3.1 1.6e-73 246.1 3.1 1.0 1 0 0 1 1 1 1 Rer1 family ECH_1 PF00378.20 EGD96078.1 - 5.7e-79 265.0 0.1 6.5e-79 264.8 0.1 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EGD96078.1 - 6e-37 127.9 0.9 4.8e-34 118.3 0.3 2.0 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase adh_short PF00106.25 EGD96080.1 - 1.1e-31 109.8 0.7 1.7e-31 109.2 0.7 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EGD96080.1 - 8e-24 84.5 0.7 1e-23 84.2 0.7 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EGD96080.1 - 1.8e-09 37.8 0.2 2.3e-09 37.4 0.2 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EGD96080.1 - 0.0019 17.7 0.1 0.0034 16.9 0.1 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EGD96080.1 - 0.0044 16.5 0.0 0.086 12.2 0.0 2.0 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 EGD96080.1 - 0.09 11.8 0.0 0.16 11.0 0.0 1.3 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 EGD96080.1 - 0.12 12.2 0.5 0.21 11.4 0.5 1.8 1 1 0 1 1 1 0 NAD(P)H-binding BTB PF00651.31 EGD96081.1 - 8.2e-16 58.2 0.1 3.8e-15 56.1 0.1 1.9 2 0 0 2 2 2 1 BTB/POZ domain RGS12_usC PF16612.5 EGD96081.1 - 0.089 13.2 0.4 10 6.5 0.1 2.3 2 0 0 2 2 2 0 C-terminal unstructured region of RGS12 A_deaminase PF00962.22 EGD96082.1 - 6.1e-25 88.2 0.0 8.1e-25 87.8 0.0 1.3 1 0 0 1 1 1 1 Adenosine/AMP deaminase Acetyltransf_1 PF00583.25 EGD96083.1 - 2.5e-10 40.6 0.0 4.7e-10 39.7 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EGD96083.1 - 6.6e-10 39.3 0.0 1.4e-09 38.2 0.0 1.5 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EGD96083.1 - 1.3e-09 38.1 0.0 5.6e-09 36.0 0.0 1.8 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EGD96083.1 - 0.00025 21.1 0.0 0.00078 19.5 0.0 1.8 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EGD96083.1 - 0.031 14.3 0.0 0.053 13.5 0.0 1.4 1 0 0 1 1 1 0 FR47-like protein Acetyltransf_CG PF14542.6 EGD96083.1 - 0.15 12.2 0.0 0.24 11.6 0.0 1.3 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase DUF3419 PF11899.8 EGD96084.1 - 8.4e-159 528.9 0.0 1.2e-158 528.3 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3419) Methyltransf_23 PF13489.6 EGD96084.1 - 1.2e-13 51.2 0.0 4.6e-13 49.3 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EGD96084.1 - 3.2e-12 47.0 0.0 1.5e-11 44.9 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EGD96084.1 - 2.7e-11 44.1 0.0 1.4e-10 41.8 0.0 2.3 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_31 PF13847.6 EGD96084.1 - 4.2e-11 42.9 0.0 1.2e-10 41.3 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EGD96084.1 - 1.8e-10 41.3 0.0 5.3e-10 39.8 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EGD96084.1 - 1.8e-08 34.0 0.0 3.3e-08 33.2 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family PCMT PF01135.19 EGD96084.1 - 0.00048 19.9 0.0 0.00092 19.0 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_32 PF13679.6 EGD96084.1 - 0.0026 17.7 0.0 0.005 16.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 EGD96084.1 - 0.01 15.3 0.0 0.75 9.2 0.0 2.4 2 0 0 2 2 2 0 Putative methyltransferase PAS_3 PF08447.12 EGD96085.1 - 1.2e-14 54.3 0.0 8.7e-11 42.0 0.0 2.3 2 0 0 2 2 2 2 PAS fold PAS PF00989.25 EGD96085.1 - 6.4e-06 26.1 0.0 0.00017 21.6 0.0 2.3 2 0 0 2 2 2 1 PAS fold PAS_9 PF13426.7 EGD96085.1 - 1.7e-05 25.0 0.0 0.0001 22.5 0.0 2.0 2 0 0 2 2 2 1 PAS domain PAS_11 PF14598.6 EGD96085.1 - 3e-05 24.1 0.0 5.7e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 PAS domain PAS_4 PF08448.10 EGD96085.1 - 0.00041 20.6 0.0 0.002 18.4 0.0 2.1 2 0 0 2 2 2 1 PAS fold Tom5 PF10642.9 EGD96085.1 - 0.12 12.5 0.1 0.25 11.4 0.1 1.6 1 0 0 1 1 1 0 Mitochondrial import receptor subunit or translocase Lipase_3 PF01764.25 EGD96086.1 - 5.8e-06 26.2 0.0 1.2e-05 25.2 0.0 1.5 1 0 0 1 1 1 1 Lipase (class 3) PGAP1 PF07819.13 EGD96086.1 - 0.023 14.4 0.2 0.36 10.5 0.0 2.2 2 0 0 2 2 2 0 PGAP1-like protein UPF0227 PF05728.12 EGD96086.1 - 0.048 13.6 0.0 0.088 12.7 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0227) Hydrolase_4 PF12146.8 EGD96086.1 - 0.15 11.3 0.0 0.25 10.6 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 VPS9 PF02204.18 EGD96087.1 - 2.1e-27 95.3 0.0 3.5e-27 94.6 0.0 1.4 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain Sel1 PF08238.12 EGD96088.1 - 2.3e-16 59.8 2.5 4.1e-06 27.3 0.3 3.8 4 0 0 4 4 4 3 Sel1 repeat TPR_6 PF13174.6 EGD96088.1 - 0.0057 17.2 2.6 0.25 12.0 0.1 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat Pkinase PF00069.25 EGD96089.1 - 6.7e-21 74.8 0.0 1.9e-20 73.4 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD96089.1 - 1.1e-09 38.0 0.0 0.0012 18.2 0.0 2.4 2 1 0 2 2 2 2 Protein tyrosine kinase Mt_ATP-synt_B PF05405.14 EGD96090.1 - 2.3e-50 170.4 9.7 2.8e-50 170.1 9.7 1.1 1 0 0 1 1 1 1 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) CBF PF03914.17 EGD96091.1 - 1.2e-35 123.1 0.3 3e-35 121.8 0.3 1.7 1 0 0 1 1 1 1 CBF/Mak21 family DUF2115 PF09888.9 EGD96091.1 - 0.006 17.1 0.0 0.021 15.3 0.0 1.9 1 0 0 1 1 1 1 Uncharacterized protein conserved in archaea (DUF2115) PRO8NT PF08082.11 EGD96091.1 - 0.056 13.4 0.0 0.14 12.1 0.0 1.6 1 0 0 1 1 1 0 PRO8NT (NUC069), PrP8 N-terminal domain DUF4806 PF16064.5 EGD96091.1 - 0.12 12.7 0.1 0.77 10.1 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4806) GPI-anchored PF10342.9 EGD96093.1 - 3.8e-14 53.2 5.9 6.6e-14 52.4 0.0 2.7 2 1 0 2 2 2 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family Mcm10 PF09332.11 EGD96093.1 - 9.6 5.5 8.9 13 5.1 8.9 1.1 1 0 0 1 1 1 0 Mcm10 replication factor Vault PF01505.18 EGD96094.1 - 0.48 10.6 2.2 0.9 9.8 2.2 1.6 1 1 0 1 1 1 0 Major Vault Protein repeat domain DUF3632 PF12311.8 EGD96095.1 - 8.3e-35 120.8 1.2 1.1e-34 120.4 1.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3632) SHE3 PF17078.5 EGD96096.1 - 1.2e-08 35.0 26.9 9e-08 32.1 24.5 2.0 1 1 1 2 2 2 2 SWI5-dependent HO expression protein 3 HSCB_C PF07743.13 EGD96096.1 - 0.046 14.2 0.8 0.046 14.2 0.8 3.7 1 1 3 4 4 4 0 HSCB C-terminal oligomerisation domain YjbH PF06082.11 EGD96096.1 - 0.21 10.4 5.3 0.24 10.2 5.3 1.2 1 0 0 1 1 1 0 Exopolysaccharide biosynthesis protein YbjH ATG16 PF08614.11 EGD96096.1 - 0.47 10.6 35.8 6 7.0 23.0 2.2 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) KASH_CCD PF14662.6 EGD96096.1 - 0.63 9.8 29.7 5.2 6.9 7.9 2.4 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 or KASH DDHD PF02862.17 EGD96096.1 - 1.3 9.1 8.3 2 8.5 8.3 1.4 1 0 0 1 1 1 0 DDHD domain MMS19_C PF12460.8 EGD96098.1 - 5.6e-122 407.9 21.0 7.4e-120 400.9 16.0 4.2 3 2 1 4 4 4 1 RNAPII transcription regulator C-terminal MMS19_N PF14500.6 EGD96098.1 - 1.8e-92 309.6 1.9 4.3e-89 298.6 0.0 4.3 4 0 0 4 4 4 1 Dos2-interacting transcription regulator of RNA-Pol-II HEAT_2 PF13646.6 EGD96098.1 - 3e-05 24.3 5.7 1.6 9.2 0.1 5.5 5 0 0 5 5 5 2 HEAT repeats M11L PF11099.8 EGD96098.1 - 0.032 14.5 0.6 3.1 8.1 0.2 2.7 2 0 0 2 2 2 0 Apoptosis regulator M11L like Cnd1 PF12717.7 EGD96098.1 - 0.096 12.7 5.9 12 5.9 0.0 4.9 4 1 0 4 4 4 0 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 EGD96098.1 - 0.11 12.8 13.0 33 5.1 0.3 6.8 8 0 0 8 8 8 0 HEAT repeat Fasciclin PF02469.22 EGD96099.1 - 0.0021 18.3 0.0 0.0037 17.5 0.0 1.4 1 1 0 1 1 1 1 Fasciclin domain EMC3_TMCO1 PF01956.16 EGD96100.1 - 1e-52 178.3 1.2 1.2e-52 178.0 1.2 1.1 1 0 0 1 1 1 1 Integral membrane protein EMC3/TMCO1-like AmpE PF17113.5 EGD96100.1 - 0.075 12.4 0.0 0.1 11.9 0.0 1.2 1 0 0 1 1 1 0 Regulatory signalling modulator protein AmpE SPC25 PF06703.11 EGD96101.1 - 2.5e-48 163.9 0.5 2.9e-48 163.7 0.5 1.0 1 0 0 1 1 1 1 Microsomal signal peptidase 25 kDa subunit (SPC25) THF_DHG_CYH PF00763.23 EGD96102.1 - 8.1e-26 90.6 0.0 1.3e-25 90.0 0.0 1.3 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain THF_DHG_CYH_C PF02882.19 EGD96102.1 - 9.4e-14 51.0 0.0 3.6e-09 36.1 0.0 2.7 2 1 0 2 2 2 2 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Fer2_BFD PF04324.15 EGD96102.1 - 0.071 13.5 0.0 0.16 12.4 0.0 1.6 1 0 0 1 1 1 0 BFD-like [2Fe-2S] binding domain ATP-synt_ab PF00006.25 EGD96103.1 - 3.1e-73 246.0 0.0 4.5e-73 245.4 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.27 EGD96103.1 - 1.7e-47 160.8 0.2 3e-47 160.1 0.2 1.4 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.23 EGD96103.1 - 5.3e-15 55.7 2.7 1.5e-14 54.3 2.7 1.8 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain DUF3659 PF12396.8 EGD96103.1 - 0.15 12.0 0.6 25 4.9 0.6 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF3659) DUF962 PF06127.11 EGD96104.1 - 2.5e-26 91.6 0.0 4.3e-26 90.8 0.0 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF962) SHS2_Rpb7-N PF03876.17 EGD96105.1 - 3.4e-14 52.9 0.1 5.3e-14 52.3 0.1 1.3 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 S1 PF00575.23 EGD96105.1 - 0.0005 20.3 0.0 0.00087 19.6 0.0 1.3 1 0 0 1 1 1 1 S1 RNA binding domain SnoaL PF07366.12 EGD96106.1 - 0.00053 19.8 0.3 0.024 14.4 0.0 2.9 2 1 0 2 2 2 1 SnoaL-like polyketide cyclase eIF-3_zeta PF05091.12 EGD96106.1 - 0.021 13.8 4.1 0.029 13.4 4.1 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) SnoaL_2 PF12680.7 EGD96106.1 - 0.16 12.6 0.0 0.36 11.5 0.0 1.6 1 0 0 1 1 1 0 SnoaL-like domain Fungal_trans PF04082.18 EGD96107.1 - 1.4e-13 50.5 0.1 2.8e-13 49.5 0.1 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EGD96107.1 - 7e-07 29.3 12.4 1.5e-06 28.2 12.4 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain HSBP1 PF06825.12 EGD96107.1 - 0.011 15.6 0.3 0.022 14.6 0.3 1.4 1 0 0 1 1 1 0 Heat shock factor binding protein 1 RRM_1 PF00076.22 EGD96108.1 - 2.5e-32 110.5 0.0 6.2e-18 64.4 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 EGD96108.1 - 0.05 13.7 0.6 0.14 12.2 0.0 2.1 3 0 0 3 3 3 0 RNA binding motif RRM_7 PF16367.5 EGD96108.1 - 0.1 12.7 0.0 8.5 6.6 0.0 2.6 2 1 0 2 2 2 0 RNA recognition motif AID PF18767.1 EGD96108.1 - 0.18 11.8 0.0 4.3 7.4 0.0 2.2 2 0 0 2 2 2 0 Activation induced deaminase TPR_1 PF00515.28 EGD96109.1 - 1.1e-26 91.5 1.8 2.7e-09 36.4 0.0 5.9 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_2 PF07719.17 EGD96109.1 - 1e-24 84.6 2.6 1.4e-07 31.0 0.0 6.0 6 0 0 6 6 5 5 Tetratricopeptide repeat TPR_11 PF13414.6 EGD96109.1 - 1.2e-19 69.7 3.9 1.8e-08 33.9 0.0 4.9 4 1 1 5 5 5 3 TPR repeat TPR_16 PF13432.6 EGD96109.1 - 2.2e-19 69.8 0.8 1.7e-05 25.3 0.0 4.5 3 1 1 4 4 4 4 Tetratricopeptide repeat TPR_14 PF13428.6 EGD96109.1 - 3.2e-18 64.8 2.2 3.5e-05 24.3 0.0 5.6 3 1 2 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.6 EGD96109.1 - 2.4e-16 58.5 0.1 7.3e-07 28.9 0.0 5.2 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_19 PF14559.6 EGD96109.1 - 8.6e-16 58.2 2.3 0.00028 21.3 0.0 4.7 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_17 PF13431.6 EGD96109.1 - 1.2e-15 56.7 1.7 0.0028 17.9 0.1 5.0 5 0 0 5 5 4 4 Tetratricopeptide repeat TPR_20 PF14561.6 EGD96109.1 - 1.5e-10 41.2 0.5 0.0057 17.0 0.0 4.6 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.6 EGD96109.1 - 2.1e-10 39.9 2.0 0.007 16.3 0.0 6.2 7 0 0 7 7 6 2 Tetratricopeptide repeat TPR_9 PF13371.6 EGD96109.1 - 2.5e-10 40.3 0.6 0.0041 17.2 0.0 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 EGD96109.1 - 3.9e-10 39.9 4.5 8.6e-06 26.0 0.3 4.1 3 2 0 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.6 EGD96109.1 - 1.5e-07 31.6 1.1 2.4 9.0 0.0 6.0 6 0 0 6 6 5 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EGD96109.1 - 5.6e-06 26.5 1.3 0.0025 18.0 0.1 2.7 2 0 0 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_15 PF13429.6 EGD96109.1 - 0.00024 20.4 0.4 0.29 10.3 0.4 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_3 PF07720.12 EGD96109.1 - 0.0025 17.8 0.1 4.3 7.4 0.0 3.2 4 0 0 4 4 3 1 Tetratricopeptide repeat MIT PF04212.18 EGD96109.1 - 0.0065 16.5 0.5 10 6.3 0.1 4.2 5 0 0 5 5 5 0 MIT (microtubule interacting and transport) domain TPR_10 PF13374.6 EGD96109.1 - 0.013 15.3 4.1 0.084 12.8 0.3 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF4192 PF13830.6 EGD96109.1 - 0.07 13.2 5.1 0.085 12.9 3.3 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF4192) TOM20_plant PF06552.12 EGD96109.1 - 0.072 12.8 0.1 4.8 6.9 0.0 2.9 3 1 0 3 3 3 0 Plant specific mitochondrial import receptor subunit TOM20 DUF1641 PF07849.11 EGD96109.1 - 0.12 12.3 0.2 0.24 11.3 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1641) NatB_MDM20 PF09797.9 EGD96109.1 - 0.21 10.5 0.0 0.37 9.7 0.0 1.4 1 0 0 1 1 1 0 N-acetyltransferase B complex (NatB) non catalytic subunit TPP_enzyme_N PF02776.18 EGD96110.1 - 1.1e-44 152.1 0.1 2.3e-44 151.1 0.1 1.5 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.22 EGD96110.1 - 1.2e-34 119.0 0.0 2.1e-34 118.2 0.0 1.4 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.21 EGD96110.1 - 2.2e-18 66.5 0.0 5e-18 65.3 0.0 1.6 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain B12-binding PF02310.19 EGD96110.1 - 0.0097 15.9 0.5 0.033 14.2 0.1 2.1 2 0 0 2 2 2 1 B12 binding domain CO_dh PF02552.16 EGD96110.1 - 0.041 13.7 0.0 0.072 12.9 0.0 1.3 1 0 0 1 1 1 0 CO dehydrogenase beta subunit/acetyl-CoA synthase epsilon subunit ERO1 PF04137.15 EGD96111.1 - 2.4e-134 448.0 0.1 8e-134 446.3 0.0 1.7 2 0 0 2 2 2 1 Endoplasmic Reticulum Oxidoreductin 1 (ERO1) GST_C PF00043.25 EGD96112.1 - 3.3e-09 36.8 0.0 5e-09 36.3 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EGD96112.1 - 2.1e-08 34.4 0.0 3.5e-08 33.7 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EGD96112.1 - 2.2e-05 24.6 0.0 3.5e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EGD96112.1 - 4e-05 24.0 0.0 9.5e-05 22.7 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EGD96112.1 - 0.0026 18.0 0.0 0.0052 17.0 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EGD96112.1 - 0.0027 17.7 0.0 0.0053 16.7 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Glutaredoxin PF00462.24 EGD96112.1 - 0.057 13.6 0.0 0.11 12.7 0.0 1.4 1 0 0 1 1 1 0 Glutaredoxin Peroxin-13_N PF04088.13 EGD96113.1 - 3.5e-51 173.3 0.0 6.3e-51 172.5 0.0 1.4 1 0 0 1 1 1 1 Peroxin 13, N-terminal region SH3_2 PF07653.17 EGD96113.1 - 6.9e-09 35.3 0.0 1.3e-08 34.4 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EGD96113.1 - 2.3e-07 30.3 0.0 4.2e-07 29.5 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EGD96113.1 - 9.9e-06 25.3 0.1 1.7e-05 24.5 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain hSH3 PF14603.6 EGD96113.1 - 0.21 12.0 0.0 0.37 11.2 0.0 1.3 1 0 0 1 1 1 0 Helically-extended SH3 domain Aminotran_5 PF00266.19 EGD96114.1 - 4.2e-29 101.6 0.0 6.9e-29 100.9 0.0 1.3 2 0 0 2 2 2 1 Aminotransferase class-V APG6 PF04111.12 EGD96115.1 - 6e-73 244.6 0.0 9e-73 244.0 0.0 1.3 1 0 0 1 1 1 1 Apg6 BARA domain APG6_N PF17675.1 EGD96115.1 - 7.6e-39 133.3 10.7 1.3e-38 132.6 10.7 1.4 1 0 0 1 1 1 1 Apg6 coiled-coil region YabA PF06156.13 EGD96115.1 - 0.082 13.5 0.9 0.19 12.4 0.9 1.6 1 0 0 1 1 1 0 Initiation control protein YabA Jnk-SapK_ap_N PF09744.9 EGD96115.1 - 1.7 8.9 11.5 3.3 7.9 11.5 1.4 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 Scm3 PF10384.9 EGD96116.1 - 2.4e-22 78.4 0.1 4.7e-22 77.5 0.1 1.5 1 0 0 1 1 1 1 Centromere protein Scm3 Myb_DNA-bind_6 PF13921.6 EGD96116.1 - 0.00047 20.3 1.6 0.58 10.5 0.0 3.0 3 0 0 3 3 3 2 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 EGD96116.1 - 0.00065 19.8 0.2 3.1 8.1 0.0 3.3 3 0 0 3 3 3 2 Myb-like DNA-binding domain PALP PF00291.25 EGD96117.1 - 3.8e-60 203.8 2.1 9.1e-60 202.5 2.1 1.6 1 1 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Methyltransf_28 PF02636.17 EGD96118.1 - 5.4e-40 137.7 0.0 1e-39 136.8 0.0 1.4 2 0 0 2 2 2 1 Putative S-adenosyl-L-methionine-dependent methyltransferase Pathogen_betaC1 PF09593.10 EGD96118.1 - 0.16 11.9 0.3 14 5.7 0.0 2.3 2 0 0 2 2 2 0 Beta-satellite pathogenicity beta C1 protein Pal1 PF08316.11 EGD96119.1 - 1.1e-07 32.7 0.2 1.7e-07 32.1 0.2 1.3 1 0 0 1 1 1 1 Pal1 cell morphology protein Terpene_synth_C PF03936.16 EGD96120.1 - 1.9e-07 30.7 0.4 4.1e-07 29.6 0.4 1.6 1 1 0 1 1 1 1 Terpene synthase family, metal binding domain HVSL PF09749.9 EGD96121.1 - 2.2e-84 282.7 0.1 2.9e-84 282.3 0.1 1.1 1 0 0 1 1 1 1 Uncharacterised conserved protein DUF3807 PF12720.7 EGD96122.1 - 4.3e-43 147.7 2.6 5.5e-43 147.3 2.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3807) DUF4640 PF15480.6 EGD96123.1 - 0.006 16.4 1.2 0.0066 16.2 1.2 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4640) PY_rept_46 PF09689.10 EGD96123.1 - 9.6 6.9 8.3 7.7 7.2 0.7 2.8 1 1 2 3 3 3 0 Plasmodium yoelii repeat (PY_rept_46) SAS4 PF15460.6 EGD96126.1 - 1.1e-31 108.9 4.3 1.1e-31 108.9 4.3 2.5 2 0 0 2 2 2 1 Something about silencing, SAS, complex subunit 4 TFIIF_alpha PF05793.12 EGD96126.1 - 0.0041 15.8 20.8 0.007 15.0 20.8 1.3 1 0 0 1 1 1 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Nop14 PF04147.12 EGD96126.1 - 0.016 13.4 19.4 0.025 12.8 19.4 1.2 1 0 0 1 1 1 0 Nop14-like family CENP-B_dimeris PF09026.10 EGD96126.1 - 0.074 13.5 10.3 0.17 12.3 10.3 1.6 1 0 0 1 1 1 0 Centromere protein B dimerisation domain TRAP_alpha PF03896.16 EGD96126.1 - 1.2 8.3 9.9 2.3 7.4 9.9 1.5 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit BSP_II PF05432.11 EGD96126.1 - 1.7 8.3 23.6 0.4 10.3 20.0 1.8 2 0 0 2 2 2 0 Bone sialoprotein II (BSP-II) BT1 PF03092.16 EGD96126.1 - 1.9 6.6 2.3 3 5.9 2.3 1.2 1 0 0 1 1 1 0 BT1 family DNA_pol_phi PF04931.13 EGD96126.1 - 2.9 5.9 18.3 4.4 5.3 18.3 1.2 1 0 0 1 1 1 0 DNA polymerase phi CDC45 PF02724.14 EGD96126.1 - 3.2 5.9 19.0 6.3 5.0 19.0 1.5 1 0 0 1 1 1 0 CDC45-like protein NOA36 PF06524.12 EGD96126.1 - 3.9 6.7 12.0 7.4 5.8 12.0 1.4 1 0 0 1 1 1 0 NOA36 protein DHHW PF14286.6 EGD96126.1 - 5 6.4 4.9 10 5.3 4.9 1.4 1 0 0 1 1 1 0 DHHW protein PX PF00787.24 EGD96127.1 - 1.1e-14 54.3 0.0 1.9e-14 53.6 0.0 1.3 1 0 0 1 1 1 1 PX domain Brix PF04427.18 EGD96129.1 - 1.4e-36 126.5 0.0 1.8e-36 126.1 0.0 1.2 1 0 0 1 1 1 1 Brix domain SH3_9 PF14604.6 EGD96130.1 - 5.7e-30 102.9 3.6 3.7e-14 52.3 0.4 2.5 2 0 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.28 EGD96130.1 - 1.8e-29 101.1 4.2 1.8e-14 53.0 0.4 2.4 2 0 0 2 2 2 2 SH3 domain SH3_2 PF07653.17 EGD96130.1 - 5.1e-16 58.1 0.1 2.6e-07 30.2 0.0 2.8 3 0 0 3 3 3 2 Variant SH3 domain Cofilin_ADF PF00241.20 EGD96130.1 - 1.5e-14 53.8 0.0 2.7e-14 53.0 0.0 1.4 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein Dynamin_M PF01031.20 EGD96131.1 - 2.2e-111 371.7 0.0 3.9e-111 370.8 0.0 1.4 1 0 0 1 1 1 1 Dynamin central region Dynamin_N PF00350.23 EGD96131.1 - 2.2e-57 193.8 0.7 1.8e-56 190.8 0.1 2.4 3 0 0 3 3 3 1 Dynamin family GED PF02212.18 EGD96131.1 - 7.5e-32 109.3 0.8 1.9e-31 108.1 0.8 1.7 1 0 0 1 1 1 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.23 EGD96131.1 - 0.00012 22.1 0.6 0.0012 18.9 0.6 2.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_21 PF13304.6 EGD96131.1 - 0.043 13.6 0.0 0.084 12.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system zf-C2H2 PF00096.26 EGD96132.1 - 0.0028 18.0 5.9 0.0028 18.0 5.9 3.7 3 0 0 3 3 3 2 Zinc finger, C2H2 type C1_4 PF07975.12 EGD96132.1 - 0.058 13.6 0.3 0.16 12.2 0.3 1.7 1 0 0 1 1 1 0 TFIIH C1-like domain zf-C2H2_4 PF13894.6 EGD96132.1 - 1.1 10.3 18.1 0.08 13.8 4.9 3.6 3 0 0 3 3 3 0 C2H2-type zinc finger AAA PF00004.29 EGD96136.1 - 9.2e-48 162.0 0.0 1.2e-42 145.5 0.0 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EGD96136.1 - 4e-06 26.5 2.3 0.0026 17.5 0.0 3.2 3 0 0 3 3 3 2 AAA+ lid domain AAA_16 PF13191.6 EGD96136.1 - 9.7e-05 22.8 0.0 0.023 15.1 0.0 3.2 2 0 0 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 EGD96136.1 - 0.00015 21.6 0.0 0.0004 20.2 0.0 1.7 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain Parvo_NS1 PF01057.17 EGD96136.1 - 0.0005 19.2 0.0 0.00094 18.3 0.0 1.3 1 0 0 1 1 1 1 Parvovirus non-structural protein NS1 RNA_helicase PF00910.22 EGD96136.1 - 0.0016 18.8 0.1 0.016 15.6 0.0 2.6 3 0 0 3 3 2 1 RNA helicase AAA_2 PF07724.14 EGD96136.1 - 0.0027 17.8 0.0 0.0083 16.3 0.0 1.9 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 EGD96136.1 - 0.0029 17.9 0.1 0.051 13.9 0.0 3.0 4 1 1 5 5 2 1 AAA domain AAA_25 PF13481.6 EGD96136.1 - 0.003 17.2 0.1 0.04 13.5 0.0 2.7 2 1 0 2 2 2 1 AAA domain PhoH PF02562.16 EGD96136.1 - 0.0056 16.2 0.0 0.2 11.1 0.0 2.4 2 0 0 2 2 2 1 PhoH-like protein TIP49 PF06068.13 EGD96136.1 - 0.0062 15.8 0.0 0.012 14.9 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain IstB_IS21 PF01695.17 EGD96136.1 - 0.0084 15.9 0.0 0.018 14.8 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein Mg_chelatase PF01078.21 EGD96136.1 - 0.024 14.0 0.1 0.05 13.0 0.1 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI ATPase PF06745.13 EGD96136.1 - 0.03 13.7 0.0 0.08 12.3 0.0 1.7 1 0 0 1 1 1 0 KaiC Vps4_C PF09336.10 EGD96136.1 - 0.031 14.3 0.5 0.61 10.1 0.1 2.7 2 0 0 2 2 2 0 Vps4 C terminal oligomerisation domain AAA_18 PF13238.6 EGD96136.1 - 0.035 14.7 0.0 0.12 12.9 0.0 2.0 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 EGD96136.1 - 0.041 13.9 0.0 0.13 12.3 0.0 1.9 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 EGD96136.1 - 0.042 13.4 0.0 0.085 12.4 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_33 PF13671.6 EGD96136.1 - 0.059 13.5 0.0 0.44 10.7 0.0 2.4 2 0 0 2 2 2 0 AAA domain TsaE PF02367.17 EGD96136.1 - 0.066 13.2 0.0 0.16 12.0 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Kinase-PolyVal PF18762.1 EGD96136.1 - 0.073 13.0 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 Serine/Threonine/Tyrosine Kinase found in polyvalent proteins AAA_28 PF13521.6 EGD96136.1 - 0.14 12.4 0.0 0.31 11.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain TPR_10 PF13374.6 EGD96137.1 - 1.2e-44 149.0 20.2 6.8e-10 38.5 0.1 7.8 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_12 PF13424.6 EGD96137.1 - 2e-43 146.5 15.1 1.3e-17 63.8 1.0 6.0 3 3 3 6 6 6 6 Tetratricopeptide repeat TPR_2 PF07719.17 EGD96137.1 - 1.7e-12 46.5 18.5 0.0078 16.3 0.1 6.4 6 1 1 7 7 7 4 Tetratricopeptide repeat TPR_7 PF13176.6 EGD96137.1 - 2.8e-10 39.5 17.7 0.002 18.0 0.0 7.2 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_1 PF00515.28 EGD96137.1 - 9e-09 34.8 17.2 4.8e-05 23.0 0.3 6.1 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_16 PF13432.6 EGD96137.1 - 1.9e-07 31.6 16.9 0.19 12.4 0.1 5.2 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.6 EGD96137.1 - 3.1e-06 26.9 17.0 0.45 10.9 0.0 7.0 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_MalT PF17874.1 EGD96137.1 - 1.2e-05 24.9 6.6 0.01 15.2 2.6 3.1 2 1 1 3 3 3 2 MalT-like TPR region TPR_4 PF07721.14 EGD96137.1 - 0.00051 20.4 1.4 6 7.8 0.0 4.7 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_14 PF13428.6 EGD96137.1 - 0.00062 20.4 8.2 13 7.0 0.0 5.8 5 1 1 6 6 6 0 Tetratricopeptide repeat TPR_17 PF13431.6 EGD96137.1 - 0.0026 18.0 8.3 1 9.9 0.3 5.3 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_11 PF13414.6 EGD96137.1 - 0.035 13.8 6.4 16 5.3 0.1 4.4 4 0 0 4 4 4 0 TPR repeat ANAPC3 PF12895.7 EGD96137.1 - 0.055 13.7 7.2 0.058 13.6 1.0 3.6 3 1 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 EGD96137.1 - 0.1 13.1 14.9 3.4 8.2 0.7 4.7 3 1 1 5 5 5 0 Tetratricopeptide repeat TPR_3 PF07720.12 EGD96137.1 - 1.2 9.2 4.7 0.67 10.0 0.2 3.0 4 0 0 4 4 4 0 Tetratricopeptide repeat MIT PF04212.18 EGD96137.1 - 1.9 8.6 16.7 1.2 9.3 0.3 4.6 4 1 1 5 5 5 0 MIT (microtubule interacting and transport) domain Questin_oxidase PF14027.6 EGD96138.1 - 1.8e-84 284.2 0.7 2.1e-84 284.0 0.7 1.0 1 0 0 1 1 1 1 Questin oxidase-like HECT_2 PF09814.9 EGD96140.1 - 3.4e-56 190.7 0.0 3.8e-56 190.6 0.0 1.0 1 0 0 1 1 1 1 HECT-like Ubiquitin-conjugating enzyme (E2)-binding HECT_2 PF09814.9 EGD96141.1 - 1.2e-44 152.7 0.1 1.3e-44 152.6 0.1 1.0 1 0 0 1 1 1 1 HECT-like Ubiquitin-conjugating enzyme (E2)-binding PI-PLC-X PF00388.19 EGD96144.1 - 9.7e-55 184.1 1.1 2.1e-40 137.6 0.0 2.4 2 0 0 2 2 2 2 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 EGD96144.1 - 2e-41 141.0 0.0 4e-41 140.0 0.0 1.6 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain DPPIV_N PF00930.21 EGD96146.1 - 6e-102 341.0 0.7 9.2e-102 340.4 0.7 1.3 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.21 EGD96146.1 - 2.2e-57 193.9 5.2 2.2e-57 193.9 5.2 1.6 2 0 0 2 2 2 1 Prolyl oligopeptidase family Peptidase_S15 PF02129.18 EGD96146.1 - 3e-05 23.8 1.3 0.00015 21.5 0.6 2.2 1 1 1 2 2 2 1 X-Pro dipeptidyl-peptidase (S15 family) PBP1_TM PF14812.6 EGD96146.1 - 0.0014 19.0 0.0 0.0033 17.8 0.0 1.6 1 0 0 1 1 1 1 Transmembrane domain of transglycosylase PBP1 at N-terminal Esterase PF00756.20 EGD96146.1 - 0.022 14.4 0.2 0.069 12.8 0.2 1.8 1 1 0 1 1 1 0 Putative esterase Abhydrolase_1 PF00561.20 EGD96146.1 - 0.051 13.2 0.0 0.098 12.3 0.0 1.5 1 0 0 1 1 1 0 alpha/beta hydrolase fold FAD_binding_2 PF00890.24 EGD96147.1 - 6.5e-125 417.5 3.8 8.3e-125 417.1 3.8 1.1 1 0 0 1 1 1 1 FAD binding domain Succ_DH_flav_C PF02910.20 EGD96147.1 - 1e-43 148.3 1.3 1.6e-43 147.8 1.3 1.3 1 0 0 1 1 1 1 Fumarate reductase flavoprotein C-term Pyr_redox_2 PF07992.14 EGD96147.1 - 2.2e-06 27.1 0.2 0.00099 18.4 0.1 2.9 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EGD96147.1 - 7.7e-06 25.2 1.1 0.014 14.5 2.1 2.3 2 0 0 2 2 2 2 Glucose inhibited division protein A Thi4 PF01946.17 EGD96147.1 - 6.8e-05 22.2 0.2 0.055 12.7 0.0 2.3 2 0 0 2 2 2 2 Thi4 family FAD_binding_3 PF01494.19 EGD96147.1 - 0.0039 16.5 0.7 0.0085 15.4 0.2 1.9 2 0 0 2 2 2 1 FAD binding domain DAO PF01266.24 EGD96147.1 - 0.049 13.2 1.9 0.18 11.3 1.8 1.9 1 1 0 1 1 1 0 FAD dependent oxidoreductase HI0933_like PF03486.14 EGD96147.1 - 0.21 10.2 1.3 0.94 8.1 0.7 2.3 3 0 0 3 3 3 0 HI0933-like protein AAA PF00004.29 EGD96148.1 - 6.1e-41 139.9 0.0 1.1e-40 139.2 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EGD96148.1 - 3.3e-05 23.6 0.0 7.8e-05 22.4 0.0 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_22 PF13401.6 EGD96148.1 - 7.2e-05 23.1 0.0 0.0073 16.6 0.0 2.4 1 1 1 2 2 2 1 AAA domain AAA_5 PF07728.14 EGD96148.1 - 0.00011 22.2 0.1 0.00043 20.3 0.0 2.2 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 EGD96148.1 - 0.00021 21.4 0.0 0.00069 19.8 0.0 1.8 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 EGD96148.1 - 0.00031 21.2 0.1 0.0076 16.7 0.1 2.4 1 1 1 2 2 2 1 AAA ATPase domain DUF815 PF05673.13 EGD96148.1 - 0.0023 17.1 0.0 0.0042 16.3 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) RuvB_N PF05496.12 EGD96148.1 - 0.0083 15.9 0.0 0.017 14.9 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_28 PF13521.6 EGD96148.1 - 0.016 15.4 0.1 0.063 13.5 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 EGD96148.1 - 0.048 13.2 0.0 0.16 11.4 0.0 1.9 1 1 0 1 1 1 0 P-loop containing dynein motor region AAA_33 PF13671.6 EGD96148.1 - 0.051 13.7 0.0 0.094 12.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EGD96148.1 - 0.062 13.7 0.0 0.16 12.4 0.0 1.7 1 0 0 1 1 1 0 RNA helicase AAA_30 PF13604.6 EGD96148.1 - 0.068 12.9 0.1 0.6 9.8 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_3 PF07726.11 EGD96148.1 - 0.089 12.7 0.0 0.16 11.9 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 EGD96148.1 - 0.095 12.4 0.0 0.24 11.1 0.0 1.9 1 1 0 1 1 1 0 AAA domain AAA_18 PF13238.6 EGD96148.1 - 0.12 13.0 0.0 0.49 10.9 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_14 PF13173.6 EGD96148.1 - 0.15 12.1 0.0 0.33 11.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain Cpn60_TCP1 PF00118.24 EGD96149.1 - 8.2e-146 486.5 13.0 9.3e-146 486.3 13.0 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family TMEM154 PF15102.6 EGD96150.1 - 0.047 13.6 3.5 0.15 12.0 0.0 2.5 2 0 0 2 2 2 0 TMEM154 protein family Beta-APP PF03494.13 EGD96150.1 - 0.3 11.0 0.7 0.48 10.3 0.7 1.3 1 0 0 1 1 1 0 Beta-amyloid peptide (beta-APP) Ribosomal_L37 PF08561.10 EGD96151.1 - 3.3e-22 79.2 0.1 5.1e-22 78.7 0.1 1.3 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L37 NMT1 PF09084.11 EGD96152.1 - 1.2e-77 260.8 0.0 1.5e-77 260.4 0.0 1.1 1 0 0 1 1 1 1 NMT1/THI5 like NMT1_2 PF13379.6 EGD96152.1 - 2.3e-05 24.2 0.0 0.85 9.3 0.0 3.1 3 0 0 3 3 3 2 NMT1-like family RRM_1 PF00076.22 EGD96155.1 - 4.4e-39 132.1 0.0 4.9e-19 67.9 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EGD96155.1 - 0.00047 20.2 0.0 0.16 12.1 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif Alg6_Alg8 PF03155.15 EGD96156.1 - 8.9e-126 420.7 22.0 1.9e-78 264.6 5.9 2.0 2 0 0 2 2 2 2 ALG6, ALG8 glycosyltransferase family EpsG PF14897.6 EGD96156.1 - 0.12 11.6 5.9 0.32 10.2 5.9 1.8 1 0 0 1 1 1 0 EpsG family COX17 PF05051.13 EGD96157.1 - 2.7e-21 75.7 5.8 3.4e-21 75.3 5.8 1.1 1 0 0 1 1 1 1 Cytochrome C oxidase copper chaperone (COX17) Cmc1 PF08583.10 EGD96157.1 - 0.0082 16.1 2.8 0.048 13.7 0.0 2.1 1 1 1 2 2 2 2 Cytochrome c oxidase biogenesis protein Cmc1 like LRR_6 PF13516.6 EGD96158.1 - 4.3e-11 41.9 1.7 0.021 14.9 0.0 7.3 8 0 0 8 8 8 1 Leucine Rich repeat LRR_4 PF12799.7 EGD96158.1 - 9.8e-09 35.4 2.7 0.17 12.3 0.5 5.4 5 0 0 5 5 5 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EGD96158.1 - 0.017 15.6 7.2 59 4.8 0.1 6.4 7 0 0 7 7 7 0 Leucine Rich Repeat BPL_N PF09825.9 EGD96158.1 - 0.58 9.2 4.6 0.85 8.6 4.6 1.2 1 0 0 1 1 1 0 Biotin-protein ligase, N terminal Nop14 PF04147.12 EGD96158.1 - 1.3 7.1 26.7 1.7 6.8 26.7 1.1 1 0 0 1 1 1 0 Nop14-like family Presenilin PF01080.17 EGD96158.1 - 4.3 6.0 6.5 5.3 5.7 6.5 1.1 1 0 0 1 1 1 0 Presenilin NOA36 PF06524.12 EGD96158.1 - 4.4 6.5 16.1 6.8 5.9 16.1 1.2 1 0 0 1 1 1 0 NOA36 protein RNA_pol_Rpc4 PF05132.14 EGD96158.1 - 5.1 7.5 6.9 8.8 6.7 6.9 1.4 1 0 0 1 1 1 0 RNA polymerase III RPC4 SDA1 PF05285.12 EGD96158.1 - 5.5 6.3 28.6 7.7 5.8 28.6 1.1 1 0 0 1 1 1 0 SDA1 MBOAT_2 PF13813.6 EGD96159.1 - 1.3e-16 60.6 0.2 3.3e-16 59.3 0.2 1.8 1 0 0 1 1 1 1 Membrane bound O-acyl transferase family Sec10 PF07393.11 EGD96160.1 - 1.1e-233 777.8 0.0 1.3e-233 777.5 0.0 1.0 1 0 0 1 1 1 1 Exocyst complex component Sec10 MarR_2 PF12802.7 EGD96160.1 - 0.079 12.9 0.3 1.5 8.8 0.0 2.9 3 0 0 3 3 3 0 MarR family TFIIS_M PF07500.14 EGD96163.1 - 3.4e-30 104.8 1.7 3.4e-30 104.8 1.7 1.9 2 1 0 2 2 2 1 Transcription factor S-II (TFIIS), central domain TFIIS_C PF01096.18 EGD96163.1 - 1.9e-18 66.0 4.7 3e-18 65.4 4.7 1.3 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS) Med26 PF08711.11 EGD96163.1 - 6.6e-13 48.5 0.4 1.5e-12 47.3 0.4 1.7 1 0 0 1 1 1 1 TFIIS helical bundle-like domain Baculo_LEF5_C PF11792.8 EGD96163.1 - 0.092 12.4 0.1 0.092 12.4 0.1 2.0 2 0 0 2 2 2 0 Baculoviridae late expression factor 5 C-terminal domain zf-LITAF-like PF10601.9 EGD96163.1 - 0.19 12.0 1.9 0.39 11.0 1.9 1.4 1 0 0 1 1 1 0 LITAF-like zinc ribbon domain SP_C-Propep PF08999.10 EGD96166.1 - 0.075 12.8 0.1 0.11 12.2 0.1 1.3 1 0 0 1 1 1 0 Surfactant protein C, N terminal propeptide DAP10 PF07213.11 EGD96166.1 - 0.42 10.6 3.2 0.29 11.1 1.4 1.7 1 1 1 2 2 2 0 DAP10 membrane protein Macoilin PF09726.9 EGD96167.1 - 1.6 7.2 12.5 2.5 6.5 12.5 1.3 1 0 0 1 1 1 0 Macoilin family Sortilin-Vps10 PF15902.5 EGD96168.1 - 7.2e-284 941.3 3.6 8e-152 506.1 0.7 2.1 2 0 0 2 2 2 2 Sortilin, neurotensin receptor 3, Sortilin_C PF15901.5 EGD96168.1 - 2.9e-94 314.1 20.7 3.2e-48 164.3 7.6 2.4 2 0 0 2 2 2 2 Sortilin, neurotensin receptor 3, C-terminal BNR PF02012.20 EGD96168.1 - 5.2e-07 28.7 28.4 0.87 9.8 0.0 9.4 10 0 0 10 10 10 6 BNR/Asp-box repeat CHB_HEX_C PF03174.13 EGD96168.1 - 0.015 15.3 0.2 2.6 8.1 0.0 3.1 2 0 0 2 2 2 0 Chitobiase/beta-hexosaminidase C-terminal domain Transp_cyt_pur PF02133.15 EGD96169.1 - 3.4e-94 316.1 36.4 4.2e-94 315.8 36.4 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin dCMP_cyt_deam_1 PF00383.23 EGD96170.1 - 3.3e-15 55.8 1.0 4e-15 55.5 1.0 1.1 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region dCMP_cyt_deam_2 PF08211.12 EGD96170.1 - 3e-08 33.9 3.4 3.5e-07 30.5 0.3 2.0 2 0 0 2 2 2 2 Cytidine and deoxycytidylate deaminase zinc-binding region LmjF365940-deam PF14421.6 EGD96170.1 - 2.4e-05 24.0 2.9 0.00066 19.3 0.2 2.1 1 1 1 2 2 2 2 A distinct subfamily of CDD/CDA-like deaminases Mito_carr PF00153.27 EGD96171.1 - 1.4e-61 204.5 1.6 3.9e-21 74.8 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Cgr1 PF03879.14 EGD96172.1 - 1.4e-34 118.7 30.9 1.7e-34 118.4 30.9 1.1 1 0 0 1 1 1 1 Cgr1 family DUF737 PF05300.11 EGD96172.1 - 0.17 12.2 19.1 0.21 11.9 19.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF737) AAA_11 PF13086.6 EGD96172.1 - 6.1 6.5 11.0 6.2 6.5 11.0 1.1 1 0 0 1 1 1 0 AAA domain CDC27 PF09507.10 EGD96172.1 - 8 5.7 23.2 9 5.6 23.2 1.0 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 YqfD PF06898.11 EGD96173.1 - 6.4 5.5 9.8 0.31 9.8 3.3 1.9 2 0 0 2 2 2 0 Putative stage IV sporulation protein YqfD SUI1 PF01253.22 EGD96174.1 - 9.8e-24 83.7 0.1 2.1e-23 82.6 0.1 1.5 1 0 0 1 1 1 1 Translation initiation factor SUI1 R3H-assoc PF13902.6 EGD96174.1 - 0.011 16.1 0.8 0.022 15.1 0.8 1.4 1 0 0 1 1 1 0 R3H-associated N-terminal domain SRP14 PF02290.15 EGD96174.1 - 0.054 13.9 0.3 0.091 13.1 0.3 1.4 1 0 0 1 1 1 0 Signal recognition particle 14kD protein Img2 PF05046.14 EGD96174.1 - 0.066 13.5 0.5 0.12 12.7 0.1 1.7 2 1 0 2 2 2 0 Mitochondrial large subunit ribosomal protein (Img2) DUF1752 PF08550.10 EGD96176.1 - 3.3e-10 39.6 2.8 8.3e-10 38.3 2.8 1.8 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) ELMO_CED12 PF04727.13 EGD96177.1 - 3e-51 174.0 0.2 5.3e-51 173.2 0.2 1.4 1 0 0 1 1 1 1 ELMO/CED-12 family PH_12 PF16457.5 EGD96177.1 - 7.4e-32 110.7 0.0 1.7e-31 109.5 0.0 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain DUF3361 PF11841.8 EGD96177.1 - 1.3e-15 57.7 0.0 3.7e-15 56.2 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF3361) Rad17 PF03215.15 EGD96178.1 - 4.2e-26 92.0 0.0 7.5e-26 91.2 0.0 1.3 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_16 PF13191.6 EGD96178.1 - 0.0002 21.8 0.0 0.00055 20.4 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain AAA_30 PF13604.6 EGD96178.1 - 0.0019 17.9 0.0 0.0034 17.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 EGD96178.1 - 0.0071 15.4 0.0 0.014 14.5 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_5 PF07728.14 EGD96178.1 - 0.0072 16.3 0.0 0.022 14.7 0.0 1.8 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_28 PF13521.6 EGD96178.1 - 0.01 16.1 0.1 0.01 16.1 0.1 1.8 2 0 0 2 2 2 0 AAA domain AAA PF00004.29 EGD96178.1 - 0.012 16.0 0.1 0.1 13.0 0.0 2.5 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 EGD96178.1 - 0.022 15.3 5.2 0.056 14.0 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_6 PF12774.7 EGD96178.1 - 0.032 13.2 0.0 0.054 12.5 0.0 1.2 1 0 0 1 1 1 0 Hydrolytic ATP binding site of dynein motor region AAA_22 PF13401.6 EGD96178.1 - 0.034 14.4 0.0 0.077 13.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 EGD96178.1 - 0.066 13.4 0.2 0.25 11.5 0.1 2.1 2 0 0 2 2 1 0 AAA domain TsaE PF02367.17 EGD96178.1 - 0.067 13.2 0.0 0.14 12.1 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_11 PF13086.6 EGD96178.1 - 0.098 12.4 1.4 1.9 8.2 0.0 2.3 2 0 0 2 2 2 0 AAA domain dNK PF01712.19 EGD96178.1 - 0.14 12.0 0.0 0.31 10.9 0.0 1.5 1 0 0 1 1 1 0 Deoxynucleoside kinase AAA_23 PF13476.6 EGD96178.1 - 0.14 12.6 2.5 2.1 8.8 0.0 2.4 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.27 EGD96178.1 - 0.2 12.2 1.7 0.35 11.4 0.0 2.3 3 0 0 3 3 3 0 ABC transporter UAA PF08449.11 EGD96179.1 - 1.9e-76 257.1 12.3 4e-76 256.1 12.3 1.5 1 1 0 1 1 1 1 UAA transporter family TMEM100 PF16311.5 EGD96179.1 - 0.095 12.3 0.4 0.24 11.0 0.4 1.6 1 0 0 1 1 1 0 Transmembrane protein 100 MFS_5 PF05631.14 EGD96180.1 - 4.7e-62 209.9 3.9 6.8e-62 209.4 3.9 1.2 1 0 0 1 1 1 1 Sugar-tranasporters, 12 TM MFS_1 PF07690.16 EGD96180.1 - 9.5e-20 70.8 32.0 3.7e-19 68.9 15.2 2.1 1 1 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EGD96180.1 - 9.8e-12 44.5 4.8 9.8e-12 44.5 4.8 2.1 3 0 0 3 3 3 1 Sugar (and other) transporter Hydrolase_6 PF13344.6 EGD96182.1 - 9.1e-21 73.9 0.0 2.8e-20 72.3 0.0 1.8 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EGD96182.1 - 3.1e-17 62.4 0.0 6.9e-17 61.3 0.0 1.6 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.26 EGD96182.1 - 0.0053 17.1 0.0 1.7 8.9 0.0 3.2 3 0 0 3 3 3 1 haloacid dehalogenase-like hydrolase Apt1 PF10351.9 EGD96182.1 - 0.064 12.1 0.0 0.064 12.1 0.0 1.4 2 0 0 2 2 2 0 Golgi-body localisation protein domain HAD_2 PF13419.6 EGD96182.1 - 0.068 13.2 0.0 1 9.4 0.0 2.3 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase Aldo_ket_red PF00248.21 EGD96183.1 - 3.5e-53 180.7 0.0 1.2e-52 179.0 0.0 1.7 1 1 0 1 1 1 1 Aldo/keto reductase family TnpV PF14198.6 EGD96183.1 - 0.0081 16.1 0.0 0.017 15.1 0.0 1.5 1 0 0 1 1 1 1 Transposon-encoded protein TnpV DUF3818 PF12825.7 EGD96184.1 - 2.7e-129 431.1 6.7 4.8e-129 430.2 6.7 1.4 1 0 0 1 1 1 1 Domain of unknown function in PX-proteins (DUF3818) PXB PF12828.7 EGD96184.1 - 7.5e-40 135.9 0.2 1.3e-39 135.1 0.2 1.4 1 0 0 1 1 1 1 PX-associated PX PF00787.24 EGD96184.1 - 4.7e-13 49.1 0.2 8.4e-12 45.1 0.0 3.0 2 1 0 2 2 2 1 PX domain GFD1 PF17331.2 EGD96184.1 - 0.075 13.2 2.2 0.31 11.3 2.2 2.0 1 0 0 1 1 1 0 GFD1 mRNA transport factor zf-GRF PF06839.12 EGD96185.1 - 2.9e-11 43.3 4.0 5.4e-11 42.4 4.0 1.5 1 0 0 1 1 1 1 GRF zinc finger Met_10 PF02475.16 EGD96187.1 - 6.6e-67 225.1 0.1 8.9e-67 224.7 0.1 1.2 1 0 0 1 1 1 1 Met-10+ like-protein TRM PF02005.16 EGD96187.1 - 0.05 12.8 0.0 0.085 12.0 0.0 1.3 1 0 0 1 1 1 0 N2,N2-dimethylguanosine tRNA methyltransferase RNA_pol_Rpb4 PF03874.16 EGD96188.1 - 2.9e-22 79.3 3.0 4.1e-22 78.8 3.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb4 Cut8 PF08559.10 EGD96188.1 - 0.0034 17.1 0.3 0.0037 16.9 0.3 1.2 1 0 0 1 1 1 1 Cut8, nuclear proteasome tether protein AMP-binding PF00501.28 EGD96189.1 - 4.6e-68 229.8 0.0 7.5e-68 229.0 0.0 1.3 1 1 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EGD96189.1 - 4.2e-10 40.5 0.0 7.9e-10 39.6 0.0 1.5 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain RhoGAP PF00620.27 EGD96190.1 - 2.2e-33 115.3 0.1 4.2e-33 114.3 0.1 1.5 1 0 0 1 1 1 1 RhoGAP domain LIM PF00412.22 EGD96190.1 - 5.2e-29 100.3 33.7 1.2e-11 44.6 6.1 4.9 5 0 0 5 5 5 4 LIM domain Nudc_N PF14050.6 EGD96190.1 - 0.19 11.8 0.0 0.45 10.5 0.0 1.6 1 0 0 1 1 1 0 N-terminal conserved domain of Nudc. Nbl1_Borealin_N PF10444.9 EGD96191.1 - 2.5e-19 68.7 5.2 4.6e-19 67.8 5.2 1.5 1 0 0 1 1 1 1 Nbl1 / Borealin N terminal VWA_2 PF13519.6 EGD96192.1 - 2.2e-18 66.8 0.0 3.8e-18 66.1 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain UIM PF02809.20 EGD96192.1 - 0.013 15.4 0.3 0.032 14.1 0.3 1.7 1 0 0 1 1 1 0 Ubiquitin interaction motif Sybindin PF04099.12 EGD96193.1 - 3.9e-46 156.5 0.0 5.9e-46 155.9 0.0 1.3 1 0 0 1 1 1 1 Sybindin-like family Sedlin_N PF04628.13 EGD96193.1 - 1.1e-06 28.8 0.0 2.1e-06 27.9 0.0 1.4 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region UQ_con PF00179.26 EGD96194.1 - 1.4e-35 122.0 0.0 6.2e-25 87.5 0.0 2.4 2 0 0 2 2 2 2 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EGD96194.1 - 2.2e-08 33.9 0.0 0.00043 20.0 0.0 2.3 2 0 0 2 2 2 2 Prokaryotic E2 family B RWD PF05773.22 EGD96194.1 - 0.0016 18.7 0.3 0.96 9.8 0.1 2.9 2 2 0 2 2 2 2 RWD domain SQS_PSY PF00494.19 EGD96196.1 - 0.043 13.3 0.0 0.064 12.7 0.0 1.2 1 0 0 1 1 1 0 Squalene/phytoene synthase FGE-sulfatase PF03781.16 EGD96197.1 - 2.2e-31 109.4 0.1 3.5e-31 108.7 0.1 1.3 1 0 0 1 1 1 1 Sulfatase-modifying factor enzyme 1 DinB_2 PF12867.7 EGD96197.1 - 2.7e-06 27.9 0.3 5.8e-06 26.8 0.3 1.6 1 0 0 1 1 1 1 DinB superfamily Methyltransf_25 PF13649.6 EGD96197.1 - 1.3e-05 25.8 0.1 0.00073 20.2 0.0 2.6 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EGD96197.1 - 0.0032 18.1 0.1 0.033 14.8 0.1 2.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EGD96197.1 - 0.025 14.4 0.1 6.6 6.5 0.0 2.7 3 0 0 3 3 3 0 Methyltransferase domain NAS PF03059.16 EGD96197.1 - 0.16 11.3 0.0 0.26 10.6 0.0 1.2 1 0 0 1 1 1 0 Nicotianamine synthase protein Methyltransf_12 PF08242.12 EGD96197.1 - 0.2 12.4 0.1 0.63 10.8 0.0 2.0 2 1 0 2 2 2 0 Methyltransferase domain Gln-synt_C PF00120.24 EGD96198.1 - 1.1e-47 162.7 0.0 8.2e-47 159.9 0.0 2.0 1 1 0 1 1 1 1 Glutamine synthetase, catalytic domain IDO PF01231.18 EGD96199.1 - 1e-33 116.8 0.0 1.4e-33 116.3 0.0 1.2 1 0 0 1 1 1 1 Indoleamine 2,3-dioxygenase PRORP PF16953.5 EGD96199.1 - 0.073 12.6 0.0 0.12 11.9 0.0 1.2 1 0 0 1 1 1 0 Protein-only RNase P APH PF01636.23 EGD96200.1 - 3.1e-11 43.6 0.0 1.8e-10 41.2 0.0 2.3 1 1 0 1 1 1 1 Phosphotransferase enzyme family 3Beta_HSD PF01073.19 EGD96201.1 - 1.3e-45 155.6 0.0 1.3e-44 152.3 0.0 1.9 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 EGD96201.1 - 6.8e-16 58.5 0.3 4.8e-15 55.7 0.0 2.3 2 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 EGD96201.1 - 3e-10 39.7 0.0 4.1e-08 32.7 0.0 2.1 2 0 0 2 2 2 2 Male sterility protein GDP_Man_Dehyd PF16363.5 EGD96201.1 - 3.5e-10 39.8 0.0 0.00012 21.6 0.0 3.3 2 1 0 3 3 3 3 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 EGD96201.1 - 0.00033 19.8 0.0 0.00098 18.3 0.0 1.7 2 0 0 2 2 2 1 RmlD substrate binding domain NAD_binding_10 PF13460.6 EGD96201.1 - 0.055 13.4 0.0 1.1 9.1 0.0 2.1 2 0 0 2 2 2 0 NAD(P)H-binding HMG_CoA_synt_C PF08540.10 EGD96202.1 - 8.1e-99 330.8 3.1 9.9e-99 330.5 3.1 1.1 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase C terminal HMG_CoA_synt_N PF01154.17 EGD96202.1 - 5.1e-87 290.2 0.0 7.6e-87 289.7 0.0 1.3 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase N terminal Pkinase PF00069.25 EGD96203.1 - 1.4e-59 201.6 0.0 4e-39 134.6 0.0 2.4 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EGD96203.1 - 7.3e-29 100.8 0.0 5.5e-21 75.0 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Response_reg PF00072.24 EGD96203.1 - 1.4e-12 47.7 0.0 2.9e-12 46.7 0.0 1.5 1 0 0 1 1 1 1 Response regulator receiver domain Kinase-like PF14531.6 EGD96203.1 - 6.5e-08 32.2 0.0 1.2e-05 24.8 0.0 2.4 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 EGD96203.1 - 8.4e-05 22.6 0.4 0.0055 16.7 0.2 2.9 2 1 1 3 3 3 1 Phosphotransferase enzyme family Kdo PF06293.14 EGD96203.1 - 0.0031 16.9 0.0 0.0057 16.0 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family PAS_9 PF13426.7 EGD96203.1 - 0.0044 17.2 0.0 0.012 15.9 0.0 1.7 1 0 0 1 1 1 1 PAS domain Haspin_kinase PF12330.8 EGD96203.1 - 0.016 14.2 0.0 0.031 13.2 0.0 1.4 1 0 0 1 1 1 0 Haspin like kinase domain PAS PF00989.25 EGD96203.1 - 0.025 14.6 0.0 0.056 13.4 0.0 1.6 1 0 0 1 1 1 0 PAS fold RIO1 PF01163.22 EGD96203.1 - 0.084 12.5 0.0 0.21 11.2 0.0 1.6 1 0 0 1 1 1 0 RIO1 family PAS_4 PF08448.10 EGD96203.1 - 0.096 12.9 0.0 0.26 11.6 0.0 1.7 1 0 0 1 1 1 0 PAS fold Seadorna_VP7 PF07387.11 EGD96203.1 - 0.16 11.0 0.1 0.3 10.1 0.1 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 eIF-3_zeta PF05091.12 EGD96204.1 - 1.8e-200 667.4 0.0 2.1e-200 667.1 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) bZIP_1 PF00170.21 EGD96205.1 - 0.0072 16.4 11.7 0.1 12.7 11.7 2.3 1 1 0 1 1 1 1 bZIP transcription factor Med9 PF07544.13 EGD96205.1 - 0.018 15.1 4.3 0.041 14.0 2.3 2.2 1 1 1 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 bZIP_2 PF07716.15 EGD96205.1 - 1 9.5 12.1 0.16 12.1 4.6 2.3 2 0 0 2 2 2 0 Basic region leucine zipper ADD_ATRX PF17981.1 EGD96206.1 - 0.047 13.6 0.1 12 5.8 0.1 2.4 2 0 0 2 2 2 0 Cysteine Rich ADD domain NOA36 PF06524.12 EGD96206.1 - 3.7 6.8 9.5 6 6.1 9.5 1.3 1 0 0 1 1 1 0 NOA36 protein Ins_P5_2-kin PF06090.12 EGD96207.1 - 4.1e-40 138.2 0.0 1e-35 123.8 0.0 2.1 1 1 0 2 2 2 2 Inositol-pentakisphosphate 2-kinase DUF4444 PF14563.6 EGD96207.1 - 0.046 13.4 0.0 0.1 12.3 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4444) Sec15 PF04091.12 EGD96208.1 - 8.9e-110 367.0 0.1 3.4e-109 365.1 0.1 2.1 1 0 0 1 1 1 1 Exocyst complex subunit Sec15-like COG2 PF06148.11 EGD96208.1 - 0.0013 18.8 4.8 0.0013 18.8 4.8 2.5 3 0 0 3 3 3 1 COG (conserved oligomeric Golgi) complex component, COG2 Sec8_exocyst PF04048.14 EGD96208.1 - 0.0018 18.2 3.2 0.0018 18.2 3.2 2.3 2 0 0 2 2 2 1 Sec8 exocyst complex component specific domain PMEI PF04043.15 EGD96208.1 - 0.046 14.1 0.6 0.11 12.9 0.6 1.6 1 0 0 1 1 1 0 Plant invertase/pectin methylesterase inhibitor Sec5 PF15469.6 EGD96208.1 - 0.085 12.7 6.4 0.39 10.5 3.3 2.9 2 0 0 2 2 2 0 Exocyst complex component Sec5 COG5 PF10392.9 EGD96208.1 - 0.33 11.1 7.3 0.37 11.0 4.7 2.6 3 0 0 3 3 3 0 Golgi transport complex subunit 5 CBFD_NFYB_HMF PF00808.23 EGD96209.1 - 1.1e-18 67.2 0.5 2e-18 66.4 0.5 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EGD96209.1 - 1.8e-15 57.5 0.1 1.8e-15 57.5 0.1 1.6 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 CENP-X PF09415.10 EGD96209.1 - 0.08 13.3 0.0 0.14 12.5 0.0 1.4 1 0 0 1 1 1 0 CENP-S associating Centromere protein X Fcf2 PF08698.11 EGD96211.1 - 1.3e-37 128.0 0.4 1.3e-37 128.0 0.4 1.9 2 0 0 2 2 2 1 Fcf2 pre-rRNA processing PNP_UDP_1 PF01048.20 EGD96212.1 - 1.2e-53 181.8 0.2 1.9e-53 181.2 0.2 1.3 1 1 0 1 1 1 1 Phosphorylase superfamily Ribosomal_S10 PF00338.22 EGD96213.1 - 2.8e-28 98.0 0.0 4.7e-28 97.3 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e tRNA-synt_1b PF00579.25 EGD96214.1 - 7.3e-68 229.0 0.0 9.3e-68 228.7 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) SWIRM PF04433.17 EGD96218.1 - 7.7e-12 45.4 0.0 2.7e-11 43.7 0.0 1.8 2 0 0 2 2 2 1 SWIRM domain CDC50 PF03381.15 EGD96219.1 - 7e-96 321.0 0.0 1e-95 320.5 0.0 1.3 1 0 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family SPT16 PF08644.11 EGD96220.1 - 1.6e-56 190.7 0.1 3.8e-56 189.5 0.1 1.7 1 0 0 1 1 1 1 FACT complex subunit (SPT16/CDC68) FACT-Spt16_Nlob PF14826.6 EGD96220.1 - 4.6e-55 185.8 0.1 1.7e-54 184.0 0.1 2.1 1 0 0 1 1 1 1 FACT complex subunit SPT16 N-terminal lobe domain Peptidase_M24 PF00557.24 EGD96220.1 - 5e-27 95.0 0.0 7.8e-27 94.3 0.0 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 Rtt106 PF08512.12 EGD96220.1 - 1.2e-13 51.3 0.1 3.1e-13 49.9 0.0 1.8 2 0 0 2 2 2 1 Histone chaperone Rttp106-like Mito_carr PF00153.27 EGD96221.1 - 8.8e-17 60.8 1.7 1.8e-10 40.6 0.0 3.3 3 1 0 3 3 3 2 Mitochondrial carrier protein GST_N_3 PF13417.6 EGD96223.1 - 1e-08 35.4 0.0 2.2e-08 34.4 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EGD96223.1 - 8.2e-08 32.4 0.0 1.5e-07 31.6 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EGD96223.1 - 5.6e-05 23.3 0.0 9.9e-05 22.5 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EGD96223.1 - 9.5e-05 22.4 0.1 0.00019 21.4 0.1 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EGD96223.1 - 0.00037 20.6 0.0 0.00082 19.6 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain DBD_Tnp_Hermes PF10683.9 EGD96223.1 - 0.042 13.5 0.0 0.1 12.3 0.0 1.6 1 0 0 1 1 1 0 Hermes transposase DNA-binding domain Sugar_tr PF00083.24 EGD96224.1 - 2.3e-102 343.2 15.4 2.8e-102 342.9 15.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EGD96224.1 - 1e-31 110.2 20.9 2.9e-31 108.7 15.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 EGD96224.1 - 3.6e-10 39.0 14.3 1.4e-05 23.9 6.3 2.4 2 0 0 2 2 2 2 MFS/sugar transport protein MFS_1_like PF12832.7 EGD96224.1 - 0.002 17.1 3.2 0.53 9.1 0.0 2.4 2 0 0 2 2 2 2 MFS_1 like family INSIG PF07281.12 EGD96224.1 - 0.073 12.7 2.0 0.2 11.3 2.0 1.8 1 0 0 1 1 1 0 Insulin-induced protein (INSIG) GRAM PF02893.20 EGD96224.1 - 0.23 11.3 0.2 0.45 10.4 0.2 1.3 1 0 0 1 1 1 0 GRAM domain AAA_lid_5 PF17865.1 EGD96225.1 - 0.039 14.0 0.8 0.06 13.4 0.1 1.7 2 0 0 2 2 2 0 Midasin AAA lid domain PMT PF02366.18 EGD96226.1 - 2.9e-88 295.6 15.8 2.9e-88 295.6 15.8 2.6 2 1 1 3 3 3 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 EGD96226.1 - 1.7e-64 217.1 17.5 1.7e-64 217.1 17.5 2.1 2 0 0 2 2 2 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 EGD96226.1 - 2.8e-35 121.9 0.1 4.5e-35 121.2 0.1 1.2 1 0 0 1 1 1 1 MIR domain HKR_ArcB_TM PF18415.1 EGD96226.1 - 0.45 11.4 4.7 0.98 10.3 0.5 3.0 2 0 0 2 2 2 0 Histidine kinase receptor ArcB trans-membrane domain Ras PF00071.22 EGD96230.1 - 1e-41 142.2 0.2 3.4e-36 124.3 0.0 3.1 3 0 0 3 3 3 3 Ras family Roc PF08477.13 EGD96230.1 - 1.2e-23 83.6 0.0 1.3e-17 64.1 0.0 3.4 3 0 0 3 3 3 3 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 EGD96230.1 - 4.4e-08 32.7 0.0 0.00017 21.1 0.0 2.1 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region Arf PF00025.21 EGD96230.1 - 1.3e-07 31.2 0.1 3.1e-07 30.0 0.1 1.6 1 1 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EGD96230.1 - 1.6e-07 31.1 0.0 2.9e-07 30.2 0.0 1.4 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EGD96230.1 - 0.0082 16.1 0.2 1.4 8.8 0.0 2.4 2 1 0 2 2 2 1 RsgA GTPase AAA_22 PF13401.6 EGD96230.1 - 0.025 14.9 0.4 0.28 11.4 0.0 2.5 3 0 0 3 3 3 0 AAA domain FAM176 PF14851.6 EGD96230.1 - 0.14 11.8 3.1 0.22 11.2 3.1 1.2 1 0 0 1 1 1 0 FAM176 family DUF2868 PF11067.8 EGD96230.1 - 0.17 11.3 0.0 0.24 10.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2868) CAP_N PF01213.19 EGD96230.1 - 4 6.8 7.3 3.2 7.1 0.2 2.1 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal Choline_transpo PF04515.12 EGD96232.1 - 3.8e-29 101.9 22.4 3.8e-29 101.9 22.4 2.3 2 0 0 2 2 2 1 Plasma-membrane choline transporter Nucleo_P87 PF07267.11 EGD96234.1 - 0.47 9.2 4.4 0.59 8.9 4.4 1.0 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 SUIM_assoc PF16619.5 EGD96234.1 - 0.84 9.8 6.9 2.6 8.2 6.9 1.9 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 Aldo_ket_red PF00248.21 EGD96235.1 - 3.8e-41 141.2 0.0 8.5e-40 136.8 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family UPF0061 PF02696.14 EGD96236.1 - 3e-131 438.4 0.0 3.9e-131 438.1 0.0 1.0 1 0 0 1 1 1 1 Uncharacterized ACR, YdiU/UPF0061 family SpoIIIAH PF12685.7 EGD96237.1 - 9.7 5.9 9.2 1 9.2 4.9 1.5 2 0 0 2 2 2 0 SpoIIIAH-like protein zf-CCHC PF00098.23 EGD96238.1 - 1e-44 148.7 58.8 1.2e-07 31.5 2.6 7.2 6 1 1 7 7 7 7 Zinc knuckle zf-CCHC_4 PF14392.6 EGD96238.1 - 1.3e-10 40.8 40.2 0.12 12.2 0.7 7.0 6 1 1 7 7 7 7 Zinc knuckle zf-CCHC_3 PF13917.6 EGD96238.1 - 5.3e-05 23.1 43.7 0.049 13.6 0.1 6.6 3 2 3 6 6 6 4 Zinc knuckle zf-CCHC_5 PF14787.6 EGD96238.1 - 0.00022 20.9 41.2 0.57 9.9 0.9 7.0 6 1 1 7 7 7 6 GAG-polyprotein viral zinc-finger zf-CCHC_6 PF15288.6 EGD96238.1 - 0.019 14.8 42.3 2.3 8.1 0.7 6.9 3 2 3 6 6 6 0 Zinc knuckle F-box PF00646.33 EGD96239.1 - 7.3e-06 25.7 0.1 1.4e-05 24.8 0.1 1.5 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EGD96239.1 - 1.4e-05 24.9 0.1 3.1e-05 23.8 0.1 1.6 1 0 0 1 1 1 1 F-box-like F-box_4 PF15966.5 EGD96239.1 - 0.17 11.7 0.2 0.47 10.4 0.0 1.8 2 0 0 2 2 2 0 F-box SAE2 PF08573.10 EGD96240.1 - 8.3e-29 100.9 3.5 5.3e-26 91.9 0.0 3.1 2 0 0 2 2 2 1 DNA repair protein endonuclease SAE2/CtIP C-terminus APG6_N PF17675.1 EGD96240.1 - 0.01 16.4 17.2 0.026 15.1 17.2 1.7 1 0 0 1 1 1 0 Apg6 coiled-coil region TMPIT PF07851.13 EGD96240.1 - 0.024 13.9 9.2 0.036 13.3 9.2 1.2 1 0 0 1 1 1 0 TMPIT-like protein Syntaxin PF00804.25 EGD96240.1 - 0.026 14.2 7.7 0.066 12.9 7.7 1.7 1 0 0 1 1 1 0 Syntaxin EzrA PF06160.12 EGD96240.1 - 0.036 12.3 11.3 0.063 11.5 11.3 1.4 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA KASH_CCD PF14662.6 EGD96240.1 - 0.04 13.7 10.5 0.11 12.3 10.5 1.7 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH HOOK PF05622.12 EGD96240.1 - 0.061 11.5 14.2 0.097 10.8 14.2 1.2 1 0 0 1 1 1 0 HOOK protein Cnn_1N PF07989.11 EGD96240.1 - 0.42 10.8 12.3 20 5.4 10.7 3.3 2 1 1 3 3 3 0 Centrosomin N-terminal motif 1 SIKE PF05769.11 EGD96240.1 - 0.44 10.5 11.6 0.88 9.5 11.6 1.5 1 0 0 1 1 1 0 SIKE family ATG16 PF08614.11 EGD96240.1 - 0.93 9.7 15.8 0.089 13.0 10.4 2.0 2 0 0 2 2 1 0 Autophagy protein 16 (ATG16) DivIC PF04977.15 EGD96240.1 - 1 9.2 8.3 0.68 9.7 5.8 2.0 1 1 0 1 1 1 0 Septum formation initiator DUF724 PF05266.14 EGD96240.1 - 1.2 9.0 11.7 2.3 8.0 11.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF724) DUF1640 PF07798.11 EGD96240.1 - 1.3 9.0 7.9 4.4 7.3 7.4 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1640) Spc7 PF08317.11 EGD96240.1 - 1.8 7.4 12.4 3 6.6 12.4 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF4407 PF14362.6 EGD96240.1 - 1.8 7.8 5.2 3.3 7.0 5.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Fib_alpha PF08702.10 EGD96240.1 - 2.1 8.5 7.4 5 7.3 7.4 1.6 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family V_ATPase_I PF01496.19 EGD96240.1 - 2.6 5.8 4.6 3.8 5.3 4.6 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family YabA PF06156.13 EGD96240.1 - 4.7 7.9 10.1 3.3 8.4 5.8 2.5 1 1 1 2 2 2 0 Initiation control protein YabA Seryl_tRNA_N PF02403.22 EGD96240.1 - 5.4 7.3 10.8 96 3.3 10.8 2.6 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain DUF3450 PF11932.8 EGD96240.1 - 5.8 6.1 10.7 9.7 5.4 10.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) Pex16 PF08610.10 EGD96241.1 - 9.1e-141 468.7 0.1 1e-140 468.5 0.1 1.0 1 0 0 1 1 1 1 Peroxisomal membrane protein (Pex16) RNase_HII PF01351.18 EGD96242.1 - 5.7e-45 153.6 0.0 2.7e-41 141.6 0.0 2.1 1 1 1 2 2 2 2 Ribonuclease HII CENP-C_C PF11699.8 EGD96243.1 - 9.9e-34 115.4 1.6 9.9e-34 115.4 1.6 2.0 2 0 0 2 2 2 1 Mif2/CENP-C like Mif2_N PF15624.6 EGD96243.1 - 1.5e-24 87.2 5.8 1.5e-24 87.2 5.8 3.8 2 1 1 4 4 4 1 Kinetochore CENP-C fungal homologue, Mif2, N-terminal Cupin_2 PF07883.11 EGD96243.1 - 2.5e-05 23.9 0.0 8e-05 22.3 0.0 1.9 1 0 0 1 1 1 1 Cupin domain CAP_GLY PF01302.25 EGD96244.1 - 1.1e-27 95.9 0.0 2e-27 95.0 0.0 1.5 1 0 0 1 1 1 1 CAP-Gly domain Ubiquitin_2 PF14560.6 EGD96244.1 - 5.1e-16 58.9 0.0 1.1e-15 57.8 0.0 1.6 2 0 0 2 2 2 1 Ubiquitin-like domain ubiquitin PF00240.23 EGD96244.1 - 4.8e-06 26.2 0.0 1.9e-05 24.3 0.0 1.9 1 1 0 1 1 1 1 Ubiquitin family Methyltransf_11 PF08241.12 EGD96245.1 - 1.9e-12 47.6 0.0 3.3e-12 46.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EGD96245.1 - 6e-10 39.7 0.0 1e-09 38.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EGD96245.1 - 1.7e-07 31.2 0.0 6.9e-07 29.2 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EGD96245.1 - 2e-06 27.7 0.0 2.8e-06 27.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EGD96245.1 - 5.8e-05 23.8 0.0 0.00011 22.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MetW PF07021.12 EGD96245.1 - 0.093 12.3 0.0 0.13 11.8 0.0 1.3 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW Myb_DNA-binding PF00249.31 EGD96247.1 - 5.2e-13 49.0 1.9 4.8e-09 36.3 0.0 2.5 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EGD96247.1 - 6.1e-07 29.6 4.3 0.00074 19.7 0.1 2.5 2 0 0 2 2 2 2 Myb-like DNA-binding domain UCH PF00443.29 EGD96251.1 - 7e-29 101.1 0.1 8.8e-29 100.8 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EGD96251.1 - 7.5e-18 65.2 3.7 5.4e-15 55.8 0.8 2.1 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase Peptidase_C98 PF15499.6 EGD96251.1 - 0.0089 15.5 4.6 0.097 12.1 0.5 2.8 3 0 0 3 3 3 2 Ubiquitin-specific peptidase-like, SUMO isopeptidase IL22 PF14565.6 EGD96251.1 - 0.026 14.8 0.0 0.05 13.9 0.0 1.4 1 0 0 1 1 1 0 Interleukin 22 IL-10-related T-cell-derived-inducible factor MitMem_reg PF13012.6 EGD96253.1 - 3.2e-36 124.1 0.3 5.9e-36 123.3 0.3 1.4 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function JAB PF01398.21 EGD96253.1 - 1e-30 106.1 0.0 2.8e-30 104.7 0.0 1.7 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease tRNA_bind_2 PF13725.6 EGD96253.1 - 0.17 11.5 7.2 0.25 11.0 7.2 1.2 1 0 0 1 1 1 0 Possible tRNA binding domain Connexin PF00029.19 EGD96253.1 - 0.47 10.2 3.1 0.82 9.4 3.1 1.4 1 0 0 1 1 1 0 Connexin ADK PF00406.22 EGD96254.1 - 8e-61 204.6 0.1 1e-60 204.2 0.1 1.1 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 EGD96254.1 - 4.7e-25 88.6 0.9 9.1e-25 87.7 0.3 1.7 1 1 1 2 2 2 1 AAA domain ADK_lid PF05191.14 EGD96254.1 - 5.2e-17 61.5 0.0 1.3e-16 60.2 0.0 1.7 2 0 0 2 2 2 1 Adenylate kinase, active site lid AAA_33 PF13671.6 EGD96254.1 - 5.2e-05 23.4 0.0 0.0001 22.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EGD96254.1 - 0.00026 21.5 0.0 0.00048 20.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain Thymidylate_kin PF02223.17 EGD96254.1 - 0.15 11.8 0.0 0.31 10.7 0.0 1.5 1 0 0 1 1 1 0 Thymidylate kinase CFIA_Pcf11 PF11526.8 EGD96256.1 - 4.6e-12 46.2 1.4 2e-11 44.2 1.4 2.1 1 0 0 1 1 1 1 Subunit of cleavage factor IA Pcf11 CTD_bind PF04818.13 EGD96256.1 - 1.7e-06 28.7 0.0 7.1e-06 26.8 0.0 2.1 2 0 0 2 2 2 1 RNA polymerase II-binding domain. VHS PF00790.19 EGD96256.1 - 0.0027 17.6 0.0 0.0088 15.9 0.0 1.8 2 0 0 2 2 2 1 VHS domain zf_UBZ PF18439.1 EGD96256.1 - 1.2 8.8 8.0 4.6 6.9 1.4 2.9 2 1 0 2 2 2 0 Ubiquitin-Binding Zinc Finger zf-C2H2_4 PF13894.6 EGD96256.1 - 2.2 9.3 3.9 39 5.5 0.4 2.5 2 0 0 2 2 2 0 C2H2-type zinc finger Inhibitor_I9 PF05922.16 EGD96257.1 - 0.014 16.1 0.0 0.023 15.4 0.0 1.5 1 1 0 1 1 1 0 Peptidase inhibitor I9 PV-1 PF06637.11 EGD96257.1 - 0.15 10.8 0.0 0.16 10.8 0.0 1.0 1 0 0 1 1 1 0 PV-1 protein (PLVAP) HOOK PF05622.12 EGD96258.1 - 3.6e-23 81.6 34.6 3.6e-23 81.6 34.6 2.9 1 1 2 3 3 3 2 HOOK protein PXA PF02194.15 EGD96258.1 - 2.8 7.9 9.4 6.1 6.8 1.5 2.8 2 0 0 2 2 2 0 PXA domain KASH_CCD PF14662.6 EGD96258.1 - 6.1 6.6 83.1 0.15 11.9 16.4 6.0 3 2 3 6 6 6 0 Coiled-coil region of CCDC155 or KASH Coprogen_oxidas PF01218.18 EGD96259.1 - 1.1e-135 451.1 0.0 1.4e-135 450.8 0.0 1.1 1 0 0 1 1 1 1 Coproporphyrinogen III oxidase Atg8 PF02991.16 EGD96260.1 - 3.1e-51 171.9 0.2 3.6e-51 171.7 0.2 1.0 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like APG12 PF04110.13 EGD96260.1 - 3.4e-06 27.4 0.0 4e-06 27.1 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 SH3_9 PF14604.6 EGD96260.1 - 0.15 11.9 0.0 9.7 6.1 0.0 2.5 2 0 0 2 2 2 0 Variant SH3 domain Mito_carr PF00153.27 EGD96262.1 - 2.6e-29 101.0 2.7 5.9e-15 55.0 0.1 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein Apc15p PF05841.11 EGD96263.1 - 2.7e-12 47.6 0.1 8.5e-12 46.0 0.0 1.8 2 0 0 2 2 2 1 Apc15p protein Use1 PF09753.9 EGD96264.1 - 0.0042 16.8 0.0 0.005 16.6 0.0 1.1 1 0 0 1 1 1 1 Membrane fusion protein Use1 CHZ PF09649.10 EGD96265.1 - 2.3e-13 49.4 0.1 2.3e-13 49.4 0.1 2.9 3 0 0 3 3 3 1 Histone chaperone domain CHZ Shugoshin_C PF07557.11 EGD96265.1 - 0.19 11.6 0.1 0.28 11.0 0.1 1.2 1 0 0 1 1 1 0 Shugoshin C terminus CDC27 PF09507.10 EGD96265.1 - 0.45 9.8 9.8 0.48 9.7 9.8 1.0 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 HSP70 PF00012.20 EGD96266.1 - 5.5e-261 867.0 7.8 6.3e-261 866.8 7.8 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EGD96266.1 - 1.8e-16 59.9 0.1 1.5e-15 56.9 0.0 2.0 2 0 0 2 2 2 1 MreB/Mbl protein FGGY_C PF02782.16 EGD96266.1 - 0.0032 17.2 0.0 0.01 15.5 0.0 1.9 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain FtsA PF14450.6 EGD96266.1 - 0.012 16.0 4.1 5.4 7.5 0.0 3.5 3 2 0 3 3 3 0 Cell division protein FtsA Hydantoinase_A PF01968.18 EGD96266.1 - 0.014 14.6 0.1 0.03 13.6 0.1 1.5 1 0 0 1 1 1 0 Hydantoinase/oxoprolinase Fungal_trans PF04082.18 EGD96267.1 - 1.2e-21 76.9 1.0 2e-21 76.3 1.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EGD96267.1 - 0.013 15.6 13.4 0.02 15.0 13.4 1.3 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain PAX PF00292.18 EGD96267.1 - 0.022 14.7 0.9 0.16 11.9 1.0 2.0 2 0 0 2 2 2 0 'Paired box' domain DIOX_N PF14226.6 EGD96269.1 - 1.1e-31 110.0 0.1 2.4e-31 108.9 0.1 1.6 1 1 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EGD96269.1 - 2.3e-16 60.1 0.0 4.4e-16 59.2 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Transp_cyt_pur PF02133.15 EGD96270.1 - 1.4e-93 314.1 32.2 1.6e-93 313.9 32.2 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin DUF485 PF04341.12 EGD96270.1 - 4 7.5 7.8 8.9 6.3 0.2 3.7 2 1 1 3 3 3 0 Protein of unknown function, DUF485 GATase_2 PF00310.21 EGD96271.1 - 1.8e-179 596.9 0.0 2.5e-179 596.4 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferases class-II Glu_synthase PF01645.17 EGD96271.1 - 2.4e-155 517.2 0.0 4.3e-155 516.4 0.0 1.4 1 0 0 1 1 1 1 Conserved region in glutamate synthase Glu_syn_central PF04898.14 EGD96271.1 - 1.1e-114 382.7 0.0 3.5e-113 377.7 0.0 2.2 2 0 0 2 2 2 1 Glutamate synthase central domain GXGXG PF01493.19 EGD96271.1 - 1.3e-84 282.6 4.3 2.1e-84 281.9 4.3 1.3 1 0 0 1 1 1 1 GXGXG motif Pyr_redox_2 PF07992.14 EGD96271.1 - 2e-25 89.6 0.1 1.1e-24 87.2 0.0 2.2 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Fer4_20 PF14691.6 EGD96271.1 - 4.3e-21 74.8 0.0 9.3e-21 73.7 0.0 1.6 1 0 0 1 1 1 1 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster NAD_binding_8 PF13450.6 EGD96271.1 - 1.8e-08 34.5 0.1 6.4e-08 32.7 0.1 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 EGD96271.1 - 7.7e-07 29.6 0.1 0.00061 20.3 0.1 3.1 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EGD96271.1 - 1.1e-06 28.5 1.7 0.0053 16.4 0.7 2.7 2 0 0 2 2 2 2 FAD dependent oxidoreductase Amino_oxidase PF01593.24 EGD96271.1 - 2.5e-06 27.1 0.2 4.7e-06 26.2 0.2 1.5 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase Pyr_redox_3 PF13738.6 EGD96271.1 - 5.7e-06 25.8 0.9 0.041 13.1 0.1 3.4 2 1 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EGD96271.1 - 1.5e-05 24.6 0.4 1.5e-05 24.6 0.4 1.7 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EGD96271.1 - 2.5e-05 23.5 1.1 0.00019 20.6 0.4 2.4 2 0 0 2 2 2 1 FAD binding domain HI0933_like PF03486.14 EGD96271.1 - 9.3e-05 21.3 0.4 9.3e-05 21.3 0.4 1.7 2 0 0 2 2 2 1 HI0933-like protein FAD_binding_3 PF01494.19 EGD96271.1 - 0.00075 18.8 0.0 0.0017 17.7 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.17 EGD96271.1 - 0.013 14.8 0.1 0.013 14.8 0.1 2.2 3 0 0 3 3 3 0 Thi4 family GIDA PF01134.22 EGD96271.1 - 0.015 14.4 2.0 0.033 13.3 0.1 2.2 2 0 0 2 2 2 0 Glucose inhibited division protein A AlaDh_PNT_C PF01262.21 EGD96271.1 - 0.022 14.0 0.3 1.3 8.3 0.1 2.4 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain FMN_dh PF01070.18 EGD96271.1 - 0.13 11.2 0.5 0.51 9.3 0.5 1.9 2 0 0 2 2 2 0 FMN-dependent dehydrogenase NAD_binding_7 PF13241.6 EGD96271.1 - 0.16 12.4 1.3 14 6.2 0.1 2.9 3 0 0 3 3 2 0 Putative NAD(P)-binding AdoHcyase_NAD PF00670.21 EGD96271.1 - 0.25 11.4 0.9 20 5.2 0.0 2.7 2 0 0 2 2 2 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain Rossmann-like PF10727.9 EGD96271.1 - 0.41 10.5 2.8 2.4 8.0 0.1 2.6 2 0 0 2 2 2 0 Rossmann-like domain DUF3128 PF11326.8 EGD96272.1 - 5.1e-27 94.1 3.7 1e-26 93.1 3.7 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3128) RNA12 PF10443.9 EGD96273.1 - 8.5e-158 525.7 1.1 2.5e-156 520.9 1.1 2.2 1 1 0 1 1 1 1 RNA12 protein ATPase_2 PF01637.18 EGD96273.1 - 0.00054 20.0 0.1 0.0048 16.9 0.1 2.2 1 1 0 1 1 1 1 ATPase domain predominantly from Archaea RRM_1 PF00076.22 EGD96273.1 - 0.0036 17.1 0.0 0.008 16.0 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF2487 PF10673.9 EGD96273.1 - 0.0049 16.9 0.2 0.017 15.2 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF2487) p450 PF00067.22 EGD96275.1 - 3.2e-06 26.2 0.0 0.0064 15.3 0.0 2.2 2 0 0 2 2 2 2 Cytochrome P450 Mcl1_mid PF12341.8 EGD96276.1 - 2.4e-104 348.8 0.0 6.8e-103 344.1 0.0 2.6 2 1 0 2 2 2 1 Minichromosome loss protein, Mcl1, middle region WD40 PF00400.32 EGD96276.1 - 1.7e-19 69.8 2.8 1.2e-08 35.5 0.1 7.6 9 0 0 9 9 9 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EGD96276.1 - 2e-17 63.2 0.0 5.6e-05 23.4 0.0 6.8 3 1 4 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain Coatomer_WDAD PF04053.14 EGD96276.1 - 2e-09 37.0 0.2 7.7e-09 35.1 0.1 1.7 1 1 1 2 2 2 1 Coatomer WD associated region eIF2A PF08662.11 EGD96276.1 - 9.1e-05 22.4 0.2 0.00047 20.1 0.0 2.2 3 0 0 3 3 3 1 Eukaryotic translation initiation factor eIF2A Frtz PF11768.8 EGD96276.1 - 0.00067 18.1 0.0 0.16 10.2 0.0 2.1 2 0 0 2 2 2 2 WD repeat-containing and planar cell polarity effector protein Fritz IKI3 PF04762.12 EGD96276.1 - 0.0013 16.9 3.0 0.011 13.8 0.2 2.9 3 1 0 3 3 3 1 IKI3 family DNA_pol_alpha_N PF12254.8 EGD96276.1 - 0.017 15.2 3.2 0.049 13.7 3.2 1.7 1 0 0 1 1 1 0 DNA polymerase alpha subunit p180 N terminal Ge1_WD40 PF16529.5 EGD96276.1 - 0.055 12.4 0.1 1 8.3 0.0 2.5 1 1 1 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein MMS1_N PF10433.9 EGD96276.1 - 0.089 11.4 0.0 0.18 10.4 0.0 1.5 1 0 0 1 1 1 0 Mono-functional DNA-alkylating methyl methanesulfonate N-term MMU163 PF17119.5 EGD96277.1 - 5.5e-114 379.5 0.0 6.9e-114 379.1 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial protein up-regulated during meiosis MFS_1 PF07690.16 EGD96278.1 - 4.3e-38 131.2 39.2 2.8e-36 125.2 21.5 1.5 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EGD96278.1 - 6e-07 28.7 6.8 1.3e-06 27.6 6.8 1.7 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_5 PF05631.14 EGD96278.1 - 0.00091 18.2 1.5 0.0016 17.5 1.5 1.3 1 0 0 1 1 1 1 Sugar-tranasporters, 12 TM LacY_symp PF01306.19 EGD96278.1 - 0.012 14.5 0.3 0.025 13.4 0.3 1.5 1 0 0 1 1 1 0 LacY proton/sugar symporter DUF1129 PF06570.11 EGD96278.1 - 0.41 10.1 2.7 14 5.1 0.2 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1129) Herpes_UL7 PF01677.16 EGD96279.1 - 0.088 12.5 0.3 0.14 11.9 0.3 1.2 1 0 0 1 1 1 0 Herpesvirus UL7 like DUF1451 PF07295.11 EGD96279.1 - 0.15 12.1 2.4 0.41 10.7 2.4 1.7 1 0 0 1 1 1 0 Zinc-ribbon containing domain DUF2347 PF09804.9 EGD96279.1 - 0.22 11.1 2.2 0.36 10.4 2.2 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2347) FAM76 PF16046.5 EGD96279.1 - 2.2 7.6 11.3 3.2 7.0 11.3 1.2 1 0 0 1 1 1 0 FAM76 protein DUF4298 PF14131.6 EGD96279.1 - 2.5 8.1 9.5 0.63 10.0 4.4 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4298) CENP-W PF15510.6 EGD96280.1 - 4e-05 23.7 0.1 4.1e-05 23.7 0.1 1.2 1 0 0 1 1 1 1 CENP-W protein CBFD_NFYB_HMF PF00808.23 EGD96280.1 - 0.00081 19.6 0.1 0.001 19.3 0.1 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone VTC PF09359.10 EGD96281.1 - 4e-83 279.0 0.1 7.9e-83 278.0 0.1 1.5 1 0 0 1 1 1 1 VTC domain DUF202 PF02656.15 EGD96281.1 - 1e-11 45.1 1.9 1e-11 45.1 1.9 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF202) SPX PF03105.19 EGD96281.1 - 4.1e-08 33.6 21.7 3.1e-07 30.7 0.0 4.2 2 2 2 4 4 4 2 SPX domain RAP1 PF07218.11 EGD96281.1 - 0.1 10.9 0.1 0.18 10.1 0.1 1.3 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Cation_efflux PF01545.21 EGD96281.1 - 0.12 12.1 0.1 0.21 11.3 0.1 1.2 1 0 0 1 1 1 0 Cation efflux family 6PF2K PF01591.18 EGD96282.1 - 1e-45 155.8 0.0 1.5e-45 155.2 0.0 1.2 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 EGD96282.1 - 5.9e-29 101.1 0.0 2.9e-22 79.3 0.0 2.5 2 0 0 2 2 2 2 Histidine phosphatase superfamily (branch 1) DUF202 PF02656.15 EGD96283.1 - 0.00093 19.6 7.9 0.0061 17.0 7.9 2.0 1 1 0 1 1 1 1 Domain of unknown function (DUF202) Myelin_PLP PF01275.19 EGD96283.1 - 0.037 13.9 0.7 0.046 13.6 0.7 1.1 1 0 0 1 1 1 0 Myelin proteolipid protein (PLP or lipophilin) F-box PF00646.33 EGD96284.1 - 3.1e-06 26.9 0.0 5.5e-06 26.1 0.0 1.4 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EGD96284.1 - 4e-05 23.4 0.4 8.8e-05 22.3 0.4 1.6 1 0 0 1 1 1 1 F-box-like zf-CHY PF05495.12 EGD96284.1 - 0.032 14.7 1.4 0.032 14.7 1.4 2.0 2 1 0 2 2 2 0 CHY zinc finger FMN_dh PF01070.18 EGD96285.1 - 1.3e-103 346.7 0.0 1.6e-103 346.4 0.0 1.1 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Cyt-b5 PF00173.28 EGD96285.1 - 1e-19 70.4 0.0 2.4e-19 69.3 0.0 1.6 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain IMPDH PF00478.25 EGD96285.1 - 7.5e-07 28.5 0.2 0.00063 18.8 0.0 2.3 2 1 0 2 2 2 2 IMP dehydrogenase / GMP reductase domain Glu_synthase PF01645.17 EGD96285.1 - 7.6e-06 25.3 0.0 1.3e-05 24.6 0.0 1.3 1 0 0 1 1 1 1 Conserved region in glutamate synthase NMO PF03060.15 EGD96285.1 - 0.03 13.7 0.3 0.19 11.1 0.1 2.0 2 0 0 2 2 2 0 Nitronate monooxygenase His_biosynth PF00977.21 EGD96285.1 - 0.092 12.2 0.0 0.19 11.2 0.0 1.5 1 0 0 1 1 1 0 Histidine biosynthesis protein Ribul_P_3_epim PF00834.19 EGD96285.1 - 0.18 11.2 0.0 0.3 10.5 0.0 1.3 1 0 0 1 1 1 0 Ribulose-phosphate 3 epimerase family Cauli_VI PF01693.16 EGD96286.1 - 1.3e-38 131.0 7.8 4.8e-20 71.6 0.6 2.4 2 0 0 2 2 2 2 Caulimovirus viroplasmin RNase_H PF00075.24 EGD96286.1 - 7.7e-37 126.6 0.1 1.3e-36 125.9 0.1 1.3 1 0 0 1 1 1 1 RNase H RVT_3 PF13456.6 EGD96286.1 - 0.01 15.6 0.0 0.02 14.7 0.0 1.7 1 1 0 1 1 1 0 Reverse transcriptase-like YmgB PF10798.8 EGD96286.1 - 0.043 13.6 0.3 0.09 12.6 0.3 1.5 1 0 0 1 1 1 0 Biofilm development protein YmgB/AriR Na_H_Exchanger PF00999.21 EGD96288.1 - 6.9e-48 163.3 20.1 8.9e-48 163.0 20.1 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family 7TM_GPCR_Srv PF10323.9 EGD96288.1 - 0.031 13.7 2.4 0.029 13.7 0.9 1.6 2 0 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srv GFO_IDH_MocA PF01408.22 EGD96289.1 - 1.1e-13 52.0 0.0 1.9e-13 51.3 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold Methyltransf_23 PF13489.6 EGD96290.1 - 2.2e-17 63.4 0.0 3.2e-17 62.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EGD96290.1 - 4.4e-09 36.9 0.0 1e-08 35.8 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EGD96290.1 - 5.6e-09 36.0 0.0 5.3e-08 32.8 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EGD96290.1 - 4.4e-08 33.8 0.0 2.4e-07 31.4 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EGD96290.1 - 2e-05 25.1 0.0 4.1e-05 24.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.19 EGD96290.1 - 0.0053 16.9 0.0 0.0079 16.3 0.0 1.2 1 0 0 1 1 1 1 FtsJ-like methyltransferase MTS PF05175.14 EGD96290.1 - 0.0067 16.0 0.0 0.022 14.3 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_4 PF02390.17 EGD96290.1 - 0.0077 15.7 0.0 0.054 13.0 0.0 2.1 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_16 PF10294.9 EGD96290.1 - 0.013 15.2 0.0 0.023 14.4 0.0 1.3 1 0 0 1 1 1 0 Lysine methyltransferase CMAS PF02353.20 EGD96290.1 - 0.085 12.1 0.0 0.53 9.5 0.0 1.9 1 1 0 1 1 1 0 Mycolic acid cyclopropane synthetase Ubie_methyltran PF01209.18 EGD96290.1 - 0.1 11.9 0.0 0.61 9.4 0.0 2.0 2 0 0 2 2 2 0 ubiE/COQ5 methyltransferase family ERG4_ERG24 PF01222.17 EGD96291.1 - 3.5e-143 477.5 21.8 4.1e-143 477.2 21.8 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family ORC6 PF05460.13 EGD96291.1 - 1.8 7.7 6.7 3.3 6.9 6.7 1.3 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) DUF2052 PF09747.9 EGD96291.1 - 1.9 8.6 5.8 2.9 8.0 5.8 1.2 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) zf-C3HC4 PF00097.25 EGD96292.1 - 1.1e-05 25.2 9.4 2.1e-05 24.3 9.4 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EGD96292.1 - 2.7e-05 24.1 5.2 2.7e-05 24.1 5.2 2.4 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_2 PF13639.6 EGD96292.1 - 0.00018 21.8 11.6 0.0031 17.8 5.7 2.3 2 0 0 2 2 2 2 Ring finger domain zf-RING_5 PF14634.6 EGD96292.1 - 0.00048 20.0 6.7 0.0011 18.9 6.6 1.7 1 1 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 EGD96292.1 - 0.00094 19.0 7.7 0.0021 17.9 7.7 1.5 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EGD96292.1 - 0.0022 17.8 6.2 0.0022 17.8 6.2 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EGD96292.1 - 0.0029 17.7 8.8 0.015 15.5 8.9 2.0 1 1 1 2 2 2 1 zinc finger of C3HC4-type, RING GAGA PF09237.11 EGD96292.1 - 0.4 10.5 2.8 0.43 10.4 0.3 2.3 2 0 0 2 2 2 0 GAGA factor UCH PF00443.29 EGD96293.1 - 2.3e-38 132.2 0.1 4.2e-34 118.2 0.0 2.3 1 1 1 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EGD96293.1 - 8.1e-10 38.8 0.0 1.7e-09 37.7 0.0 1.5 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase DLH PF01738.18 EGD96294.1 - 6.8e-27 94.4 0.0 8e-27 94.2 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family BAAT_C PF08840.11 EGD96294.1 - 0.0054 16.7 0.0 0.11 12.4 0.0 2.1 1 1 1 2 2 2 1 BAAT / Acyl-CoA thioester hydrolase C terminal Peptidase_S15 PF02129.18 EGD96294.1 - 0.022 14.4 0.0 0.026 14.1 0.0 1.3 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) Chs7 PF12271.8 EGD96295.1 - 4.8e-108 360.9 7.0 5.4e-108 360.7 7.0 1.0 1 0 0 1 1 1 1 Chitin synthase export chaperone MpPF26 PF07666.11 EGD96295.1 - 0.019 15.1 4.1 0.019 15.1 4.1 3.0 3 2 1 4 4 4 0 M penetrans paralogue family 26 DUF2569 PF10754.9 EGD96295.1 - 0.022 15.2 16.9 0.049 14.1 8.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2569) PsbW PF07123.12 EGD96295.1 - 0.21 11.6 1.5 1.5 8.9 0.2 2.3 2 0 0 2 2 2 0 Photosystem II reaction centre W protein (PsbW) UPF0220 PF05255.11 EGD96295.1 - 0.56 9.7 6.3 0.19 11.3 0.9 2.5 2 2 0 2 2 2 0 Uncharacterised protein family (UPF0220) EMP70 PF02990.16 EGD96295.1 - 7.4 5.1 13.0 0.28 9.8 6.1 1.8 2 0 0 2 2 2 0 Endomembrane protein 70 Glyoxalase PF00903.25 EGD96296.1 - 6e-06 26.5 0.3 2.1e-05 24.7 0.3 1.8 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Imm52 PF15579.6 EGD96296.1 - 0.2 11.5 0.0 0.27 11.1 0.0 1.2 1 0 0 1 1 1 0 Immunity protein 52 Nuclease_act PF08133.11 EGD96296.1 - 0.26 11.5 2.0 15 5.9 0.0 2.8 2 0 0 2 2 2 0 Anticodon nuclease activator family BC10 PF06726.12 EGD96297.1 - 4.8e-17 62.0 9.9 9.2e-17 61.0 9.9 1.5 1 0 0 1 1 1 1 Bladder cancer-related protein BC10 Ge1_WD40 PF16529.5 EGD96298.1 - 0.0073 15.3 0.0 0.021 13.8 0.0 1.7 1 1 0 1 1 1 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Importin_rep_6 PF18829.1 EGD96298.1 - 0.076 13.2 1.9 0.13 12.4 0.2 2.1 2 0 0 2 2 2 0 Importin repeat 6 KfrA_N PF11740.8 EGD96298.1 - 0.29 11.8 4.3 3.5 8.4 0.8 3.6 2 1 1 3 3 3 0 Plasmid replication region DNA-binding N-term EMP24_GP25L PF01105.24 EGD96298.1 - 3.2 7.7 5.6 40 4.1 1.2 3.2 3 0 0 3 3 3 0 emp24/gp25L/p24 family/GOLD IZUMO PF15005.6 EGD96298.1 - 4.5 7.8 5.9 1 9.9 1.4 2.2 2 0 0 2 2 2 0 Izumo sperm-egg fusion, Ig domain-associated dCMP_cyt_deam_1 PF00383.23 EGD96299.1 - 0.00011 22.1 0.0 0.00035 20.4 0.0 1.9 1 1 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region DUF4819 PF16090.5 EGD96299.1 - 0.063 13.4 0.1 0.28 11.3 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4819) Cyclin PF08613.11 EGD96300.1 - 1.2e-29 103.7 1.6 1.2e-29 103.7 1.6 3.0 2 2 0 2 2 2 1 Cyclin Cyclin_N PF00134.23 EGD96300.1 - 0.00044 20.0 0.0 0.00044 20.0 0.0 2.1 2 0 0 2 2 2 1 Cyclin, N-terminal domain Spt20 PF12090.8 EGD96300.1 - 0.012 15.2 14.1 0.012 15.2 14.1 2.3 2 0 0 2 2 2 0 Spt20 family DUF966 PF06136.13 EGD96300.1 - 0.04 13.6 11.5 0.055 13.2 11.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF966) TFIIA PF03153.13 EGD96300.1 - 2 8.3 36.9 2.8 7.9 36.9 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Arm PF00514.23 EGD96301.1 - 2.3e-12 46.5 14.9 0.0091 16.0 0.5 8.7 9 0 0 9 9 9 5 Armadillo/beta-catenin-like repeat HEAT PF02985.22 EGD96301.1 - 0.46 10.9 19.3 1.9 9.0 0.1 7.0 9 0 0 9 9 9 0 HEAT repeat Fructosamin_kin PF03881.14 EGD96302.1 - 6.2e-72 242.2 0.0 8.9e-71 238.4 0.0 2.0 1 1 0 1 1 1 1 Fructosamine kinase APH PF01636.23 EGD96302.1 - 0.00078 19.4 0.0 0.0015 18.5 0.0 1.5 1 1 0 1 1 1 1 Phosphotransferase enzyme family GST_N_3 PF13417.6 EGD96303.1 - 4.1e-15 55.9 0.0 7.9e-15 55.0 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EGD96303.1 - 4.5e-15 55.7 0.0 8.8e-15 54.8 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 EGD96303.1 - 0.00047 20.4 0.0 0.001 19.3 0.0 1.7 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EGD96303.1 - 0.044 13.8 0.0 0.088 12.8 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_C_5 PF16865.5 EGD96303.1 - 0.061 13.9 0.0 0.1 13.2 0.0 1.3 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_N_4 PF17172.4 EGD96303.1 - 0.09 13.5 0.0 0.2 12.4 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase N-terminal domain zf-C2H2_jaz PF12171.8 EGD96304.1 - 0.008 16.4 1.9 0.4 11.0 0.3 2.5 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf_UBZ PF18439.1 EGD96304.1 - 0.0086 15.6 2.8 0.76 9.4 0.1 2.5 2 0 0 2 2 2 2 Ubiquitin-Binding Zinc Finger zf-met PF12874.7 EGD96304.1 - 0.021 15.2 0.5 0.021 15.2 0.5 3.1 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf_C2H2_6 PF18450.1 EGD96304.1 - 0.062 13.0 0.2 0.16 11.7 0.0 1.8 2 0 0 2 2 2 0 Zinc Finger domain zf-C2H2 PF00096.26 EGD96304.1 - 0.11 13.0 0.2 0.11 13.0 0.2 2.9 3 0 0 3 3 3 0 Zinc finger, C2H2 type Zn-ribbon_8 PF09723.10 EGD96304.1 - 0.34 11.1 5.6 0.32 11.2 3.3 2.1 2 0 0 2 2 2 0 Zinc ribbon domain PhnA_Zn_Ribbon PF08274.12 EGD96304.1 - 0.52 10.3 5.5 6.2 6.9 5.7 2.3 1 1 0 1 1 1 0 PhnA Zinc-Ribbon DUF1610 PF07754.11 EGD96304.1 - 0.57 10.2 7.5 0.75 9.8 0.7 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1610) zf-C2H2_9 PF16293.5 EGD96304.1 - 0.83 9.5 0.1 0.83 9.5 0.1 2.8 3 0 0 3 3 3 0 C2H2 type zinc-finger (1 copy) zf-C2H2_4 PF13894.6 EGD96304.1 - 0.83 10.7 8.7 2.5 9.2 0.3 3.3 3 0 0 3 3 3 0 C2H2-type zinc finger Rhodanese_C PF12368.8 EGD96304.1 - 1.6 9.1 6.1 0.56 10.6 2.1 2.1 2 0 0 2 2 2 0 Rhodanase C-terminal zf-ACC PF17848.1 EGD96304.1 - 2.5 8.3 5.4 28 4.9 0.1 2.5 2 0 0 2 2 2 0 Acetyl-coA carboxylase zinc finger domain Rubredoxin_2 PF18073.1 EGD96304.1 - 7.3 6.4 11.1 19 5.1 2.9 3.6 3 1 0 3 3 3 0 Rubredoxin metal binding domain zf-RING_7 PF02591.15 EGD96304.1 - 8.3 6.7 6.8 14 6.0 5.4 2.1 2 0 0 2 2 2 0 C4-type zinc ribbon domain zf-C2H2_jaz PF12171.8 EGD96305.1 - 1.6e-07 31.4 39.8 0.021 15.1 0.3 7.1 5 2 2 7 7 7 4 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 EGD96305.1 - 7.1e-05 23.3 40.6 0.06 14.2 0.1 7.6 7 1 1 8 8 8 4 C2H2-type zinc finger zf-met PF12874.7 EGD96305.1 - 0.00023 21.4 33.8 0.4 11.2 0.7 6.8 6 1 0 6 6 6 4 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 EGD96305.1 - 0.00076 19.4 0.2 0.00076 19.4 0.2 5.8 6 0 0 6 6 6 1 C2H2-type zinc finger zf-C2H2 PF00096.26 EGD96305.1 - 0.003 17.9 0.2 0.003 17.9 0.2 8.3 7 1 1 8 8 8 2 Zinc finger, C2H2 type zf-C2H2_2 PF12756.7 EGD96305.1 - 0.065 13.6 38.2 1.2 9.6 6.9 4.2 1 1 1 3 3 3 0 C2H2 type zinc-finger (2 copies) DUF4520 PF15016.6 EGD96305.1 - 0.066 13.3 0.8 3.6 7.7 0.3 2.9 2 1 0 2 2 2 0 Domain of unknown function (DUF4520) DUF1477 PF07346.11 EGD96305.1 - 0.26 11.6 7.1 2.7 8.3 0.3 3.5 1 1 3 4 4 4 0 Protein of unknown function (DUF1477) Cyclin_N PF00134.23 EGD96306.1 - 1e-08 35.0 0.0 6.6e-07 29.1 0.0 2.4 2 0 0 2 2 2 2 Cyclin, N-terminal domain MRP-S34 PF16053.5 EGD96306.1 - 0.0071 16.0 0.0 0.016 14.9 0.0 1.5 1 0 0 1 1 1 1 Mitochondrial 28S ribosomal protein S34 CTP_transf_1 PF01148.20 EGD96307.1 - 9.4e-82 274.7 21.8 1.2e-81 274.4 21.8 1.1 1 0 0 1 1 1 1 Cytidylyltransferase family DUF3636 PF12331.8 EGD96308.1 - 4.9e-44 149.8 0.0 1e-43 148.7 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF3636) DUF1192 PF06698.11 EGD96308.1 - 0.0028 17.7 2.0 0.01 15.8 2.0 2.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1192) Takusan PF04822.13 EGD96308.1 - 0.02 14.8 0.5 0.02 14.8 0.5 2.3 2 0 0 2 2 2 0 Takusan MOZART1 PF12554.8 EGD96308.1 - 0.12 12.2 0.0 0.46 10.3 0.0 1.9 2 0 0 2 2 2 0 Mitotic-spindle organizing gamma-tubulin ring associated LUD_dom PF02589.15 EGD96308.1 - 0.38 10.4 1.5 0.72 9.5 1.5 1.4 1 0 0 1 1 1 0 LUD domain LCD1 PF09798.9 EGD96308.1 - 0.49 8.9 15.1 0.91 8.0 0.0 2.8 2 1 0 2 2 2 0 DNA damage checkpoint protein CorA PF01544.18 EGD96308.1 - 0.84 8.9 3.1 1.7 7.9 3.1 1.4 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein TMF_TATA_bd PF12325.8 EGD96308.1 - 1.5 9.1 12.1 0.24 11.6 6.9 2.4 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding DUF4164 PF13747.6 EGD96308.1 - 2 8.8 13.5 0.13 12.6 3.8 2.9 1 1 0 2 2 2 0 Domain of unknown function (DUF4164) PRKG1_interact PF15898.5 EGD96308.1 - 2.8 8.9 18.6 0.7 10.8 8.5 3.5 3 0 0 3 3 3 0 cGMP-dependent protein kinase interacting domain SDA1 PF05285.12 EGD96309.1 - 0.14 11.6 15.6 0.13 11.7 15.6 1.0 1 0 0 1 1 1 0 SDA1 NOA36 PF06524.12 EGD96309.1 - 0.3 10.4 21.7 0.36 10.1 21.7 1.3 1 0 0 1 1 1 0 NOA36 protein CDC45 PF02724.14 EGD96309.1 - 0.52 8.5 13.1 0.51 8.6 13.1 1.0 1 0 0 1 1 1 0 CDC45-like protein Nop14 PF04147.12 EGD96309.1 - 0.54 8.4 18.3 0.51 8.5 18.3 1.0 1 0 0 1 1 1 0 Nop14-like family CobT PF06213.12 EGD96309.1 - 1.4 8.3 17.4 1.6 8.1 17.4 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT PPP4R2 PF09184.11 EGD96309.1 - 2.3 7.7 20.3 3 7.4 20.3 1.2 1 0 0 1 1 1 0 PPP4R2 Sigma70_ner PF04546.13 EGD96309.1 - 6.4 6.6 14.7 8.2 6.3 14.7 1.3 1 0 0 1 1 1 0 Sigma-70, non-essential region TFB6 PF17110.5 EGD96309.1 - 7.7 6.2 10.1 8.7 6.1 10.1 1.1 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH FA_desaturase PF00487.24 EGD96310.1 - 3.5e-16 59.8 25.5 3.5e-16 59.8 25.5 1.9 1 1 1 2 2 2 1 Fatty acid desaturase GDPD PF03009.17 EGD96311.1 - 7.6e-17 61.9 0.0 1.1e-16 61.4 0.0 1.2 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family adh_short PF00106.25 EGD96312.1 - 6.9e-18 64.8 0.0 7.6e-12 45.1 0.0 2.2 2 0 0 2 2 2 2 short chain dehydrogenase Epimerase PF01370.21 EGD96312.1 - 2.9e-06 26.9 0.0 0.023 14.2 0.0 2.4 2 1 0 2 2 2 2 NAD dependent epimerase/dehydratase family KR PF08659.10 EGD96312.1 - 2.8e-05 24.1 0.0 5.6e-05 23.1 0.0 1.5 1 0 0 1 1 1 1 KR domain NAD_binding_4 PF07993.12 EGD96312.1 - 0.00025 20.3 0.0 0.00065 18.9 0.0 1.7 2 0 0 2 2 2 1 Male sterility protein adh_short_C2 PF13561.6 EGD96312.1 - 0.018 14.6 0.0 0.18 11.3 0.0 2.0 2 0 0 2 2 2 0 Enoyl-(Acyl carrier protein) reductase NAD_binding_10 PF13460.6 EGD96312.1 - 0.049 13.5 0.0 1.4 8.8 0.0 2.4 2 0 0 2 2 2 0 NAD(P)H-binding Polysacc_synt_2 PF02719.15 EGD96312.1 - 0.081 12.0 0.0 0.36 9.9 0.0 1.9 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein Semialdhyde_dh PF01118.24 EGD96312.1 - 0.17 12.3 0.0 0.35 11.3 0.0 1.5 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain MFS_1 PF07690.16 EGD96313.1 - 5.2e-30 104.6 28.3 5.2e-30 104.6 28.3 1.7 1 1 0 1 1 1 1 Major Facilitator Superfamily FtsX PF02687.21 EGD96314.1 - 1.6 9.2 7.1 0.26 11.8 2.0 2.1 2 0 0 2 2 2 0 FtsX-like permease family MTS PF05175.14 EGD96315.1 - 6.8e-07 29.0 0.0 6.2e-05 22.6 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_31 PF13847.6 EGD96315.1 - 9e-07 28.8 0.0 1.5e-06 28.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EGD96315.1 - 0.00011 22.9 0.0 0.00024 21.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain N6_Mtase PF02384.16 EGD96315.1 - 0.00036 19.9 0.0 0.00087 18.6 0.0 1.5 1 1 0 1 1 1 1 N-6 DNA Methylase Methyltransf_10 PF05971.12 EGD96315.1 - 0.00054 19.4 0.0 0.0019 17.6 0.0 1.7 2 0 0 2 2 2 1 RNA methyltransferase PrmA PF06325.13 EGD96315.1 - 0.0011 18.5 0.0 0.0015 18.0 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) AviRa PF11599.8 EGD96315.1 - 0.0015 18.0 0.0 0.0025 17.3 0.0 1.4 1 0 0 1 1 1 1 RRNA methyltransferase AviRa PrmC_N PF17827.1 EGD96315.1 - 0.0019 18.8 0.7 0.0019 18.8 0.7 2.9 3 1 0 3 3 3 1 PrmC N-terminal domain Ubie_methyltran PF01209.18 EGD96315.1 - 0.0033 16.8 0.0 0.0049 16.2 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 EGD96315.1 - 0.13 13.0 0.0 0.26 12.1 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain CheR PF01739.18 EGD96315.1 - 0.18 11.3 0.0 0.3 10.5 0.0 1.2 1 0 0 1 1 1 0 CheR methyltransferase, SAM binding domain Asp PF00026.23 EGD96316.1 - 5.1e-65 219.9 0.1 6.7e-65 219.6 0.1 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EGD96316.1 - 7.3e-14 52.4 1.1 7.7e-10 39.3 2.1 3.1 2 1 0 2 2 2 2 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 EGD96316.1 - 2.4e-05 24.9 0.4 0.081 13.6 0.1 3.7 2 1 0 2 2 2 2 Aspartyl protease gag-asp_proteas PF13975.6 EGD96316.1 - 0.0012 19.4 0.0 0.43 11.2 0.0 3.4 2 1 0 2 2 2 1 gag-polyprotein putative aspartyl protease TAXi_C PF14541.6 EGD96316.1 - 0.17 11.6 0.0 0.35 10.6 0.0 1.5 1 0 0 1 1 1 0 Xylanase inhibitor C-terminal zf-C2H2 PF00096.26 EGD96319.1 - 0.0058 17.0 3.1 0.016 15.6 3.1 1.8 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EGD96319.1 - 0.0086 16.5 2.4 0.77 10.3 0.1 2.6 2 0 0 2 2 2 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 EGD96319.1 - 0.094 13.6 1.8 0.25 12.3 1.8 1.8 1 0 0 1 1 1 0 C2H2-type zinc finger Thiamine_BP PF01910.17 EGD96326.1 - 4.3e-18 65.0 0.2 4.8e-18 64.9 0.2 1.0 1 0 0 1 1 1 1 Thiamine-binding protein TPR_8 PF13181.6 EGD96327.1 - 8.3e-06 25.6 0.2 0.051 13.8 0.0 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 EGD96327.1 - 0.0019 18.5 1.7 16 5.9 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 EGD96327.1 - 0.012 16.4 4.8 3.1 8.8 0.0 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.6 EGD96327.1 - 0.049 14.1 5.8 4.9 7.7 0.1 4.1 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.17 EGD96327.1 - 0.26 11.5 6.3 3.2 8.1 0.0 4.3 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_1 PF00515.28 EGD96327.1 - 0.27 11.1 2.6 6.6 6.7 0.0 3.5 4 0 0 4 4 4 0 Tetratricopeptide repeat PH_10 PF15411.6 EGD96328.1 - 7.5e-15 55.3 0.0 6.5e-09 36.1 0.0 2.4 2 0 0 2 2 2 2 Pleckstrin homology domain VWA PF00092.28 EGD96328.1 - 1.3e-12 48.3 0.0 2.2e-12 47.6 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.6 EGD96328.1 - 1.7e-08 34.5 0.0 3.7e-07 30.2 0.0 2.8 2 1 0 2 2 2 1 von Willebrand factor type A domain VWA_2 PF13519.6 EGD96328.1 - 1.9e-06 28.4 0.0 5e-06 27.1 0.0 1.7 1 0 0 1 1 1 1 von Willebrand factor type A domain zf-RING_5 PF14634.6 EGD96328.1 - 0.00023 21.0 4.0 0.00038 20.3 4.0 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 EGD96328.1 - 0.002 18.4 4.8 0.0036 17.6 4.8 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 EGD96328.1 - 0.028 14.3 4.4 0.05 13.5 4.4 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EGD96328.1 - 0.035 14.0 4.2 0.066 13.1 4.2 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EGD96328.1 - 0.07 13.0 1.9 0.13 12.1 1.9 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 EGD96328.1 - 0.12 12.0 5.9 0.044 13.4 2.9 1.8 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type zf-rbx1 PF12678.7 EGD96328.1 - 0.13 12.6 2.3 0.27 11.6 2.3 1.5 1 0 0 1 1 1 0 RING-H2 zinc finger domain Prok-RING_4 PF14447.6 EGD96328.1 - 0.37 10.7 3.5 0.73 9.7 3.5 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-RING-like PF08746.11 EGD96328.1 - 0.5 10.7 3.5 0.9 9.9 3.5 1.4 1 0 0 1 1 1 0 RING-like domain zf-C3H2C3 PF17122.5 EGD96328.1 - 1.6 8.8 5.0 4.4 7.4 5.0 1.8 1 1 0 1 1 1 0 Zinc-finger Ribosomal_L12 PF00542.19 EGD96329.1 - 6.1e-22 77.7 8.3 1.6e-20 73.2 6.0 2.2 2 0 0 2 2 2 2 Ribosomal protein L7/L12 C-terminal domain Ribosomal_L12_N PF16320.5 EGD96329.1 - 9.9e-13 47.6 8.6 9.9e-13 47.6 8.6 3.4 3 1 0 3 3 3 1 Ribosomal protein L7/L12 dimerisation domain Ribosomal_60s PF00428.19 EGD96329.1 - 0.00094 19.7 4.1 0.00094 19.7 4.1 2.2 2 1 0 2 2 2 1 60s Acidic ribosomal protein SpoVIF PF14069.6 EGD96329.1 - 0.092 12.5 3.1 0.2 11.4 0.3 2.5 2 1 0 2 2 2 0 Stage VI sporulation protein F Cpn60_TCP1 PF00118.24 EGD96330.1 - 9.3e-147 489.6 6.0 1.1e-146 489.4 6.0 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family GP24_25 PF17388.2 EGD96330.1 - 0.071 13.1 0.6 0.22 11.5 0.6 1.8 1 0 0 1 1 1 0 Tail assembly gene products 24 & 25 NOA36 PF06524.12 EGD96330.1 - 1.1 8.5 3.8 1.7 7.9 3.8 1.2 1 0 0 1 1 1 0 NOA36 protein DUF4632 PF15451.6 EGD96330.1 - 3.7 7.7 5.3 8.8 6.5 5.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4632) DNA_pol_phi PF04931.13 EGD96330.1 - 5.1 5.1 6.1 7.4 4.5 6.1 1.1 1 0 0 1 1 1 0 DNA polymerase phi E1_dh PF00676.20 EGD96331.1 - 9.1e-113 376.1 0.2 1.3e-112 375.6 0.2 1.2 1 0 0 1 1 1 1 Dehydrogenase E1 component DXP_synthase_N PF13292.6 EGD96331.1 - 7.4e-05 22.1 0.1 0.00014 21.2 0.1 1.4 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase TPP_enzyme_C PF02775.21 EGD96331.1 - 0.03 14.1 2.0 0.07 12.9 2.0 1.6 1 0 0 1 1 1 0 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain S4 PF01479.25 EGD96333.1 - 2.8e-15 55.8 0.1 6.7e-15 54.5 0.0 1.7 2 0 0 2 2 2 1 S4 domain S4_2 PF13275.6 EGD96333.1 - 0.12 12.2 0.0 0.24 11.2 0.0 1.4 1 0 0 1 1 1 0 S4 domain PAP1 PF08601.10 EGD96333.1 - 0.23 11.2 18.9 0.33 10.6 18.9 1.2 1 0 0 1 1 1 0 Transcription factor PAP1 Pex14_N PF04695.13 EGD96333.1 - 0.31 11.7 14.1 0.15 12.8 9.6 2.5 3 0 0 3 3 3 0 Peroxisomal membrane anchor protein (Pex14p) conserved region NPV_P10 PF05531.12 EGD96333.1 - 1.1 9.8 3.5 3 8.4 0.2 2.2 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein ASD2 PF08687.11 EGD96333.1 - 9.2 5.7 12.8 0.8 9.2 6.6 1.9 2 0 0 2 2 2 0 Apx/Shroom domain ASD2 Abhydrolase_1 PF00561.20 EGD96334.1 - 2.9e-24 86.1 0.3 1e-17 64.7 0.1 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EGD96334.1 - 4e-20 73.4 1.3 5e-20 73.0 1.3 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EGD96334.1 - 1.7e-09 37.3 0.2 9.9e-09 34.8 0.2 1.9 1 1 0 1 1 1 1 Serine aminopeptidase, S33 PGAP1 PF07819.13 EGD96334.1 - 4.7e-05 23.2 0.3 0.013 15.2 0.3 2.1 1 1 0 1 1 1 1 PGAP1-like protein Esterase PF00756.20 EGD96334.1 - 0.00039 20.1 0.1 0.0021 17.7 0.1 2.0 1 1 0 1 1 1 1 Putative esterase Thioesterase PF00975.20 EGD96334.1 - 0.0024 18.0 0.0 0.0042 17.2 0.0 1.4 1 0 0 1 1 1 1 Thioesterase domain UPF0227 PF05728.12 EGD96334.1 - 0.0091 16.0 0.0 0.015 15.2 0.0 1.4 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0227) Chlorophyllase PF07224.11 EGD96334.1 - 0.029 13.4 0.0 0.056 12.5 0.0 1.4 1 0 0 1 1 1 0 Chlorophyllase Palm_thioest PF02089.15 EGD96334.1 - 0.058 13.2 0.0 0.081 12.8 0.0 1.2 1 0 0 1 1 1 0 Palmitoyl protein thioesterase Abhydro_lipase PF04083.16 EGD96334.1 - 0.13 11.8 0.8 0.29 10.7 0.1 1.9 2 0 0 2 2 2 0 Partial alpha/beta-hydrolase lipase region PAF-AH_p_II PF03403.13 EGD96334.1 - 0.23 9.9 0.2 3.6 6.0 0.0 2.0 1 1 1 2 2 2 0 Platelet-activating factor acetylhydrolase, isoform II APH PF01636.23 EGD96335.1 - 9.4e-08 32.3 1.3 5.9e-07 29.6 0.0 2.1 1 1 0 2 2 2 1 Phosphotransferase enzyme family T2SSK PF03934.13 EGD96335.1 - 0.099 12.0 0.1 0.15 11.5 0.1 1.2 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein K DUF4902 PF16245.5 EGD96335.1 - 0.13 12.2 0.3 0.28 11.1 0.2 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4902) AA_permease_2 PF13520.6 EGD96336.1 - 7e-64 216.2 42.9 9e-64 215.9 42.9 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EGD96336.1 - 5.2e-29 101.2 40.2 3e-28 98.6 29.1 2.1 2 0 0 2 2 2 2 Amino acid permease NAD_binding_1 PF00175.21 EGD96337.1 - 5.7e-08 33.4 0.0 6.3e-05 23.6 0.0 2.4 2 0 0 2 2 2 2 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 EGD96337.1 - 0.00019 21.8 0.0 0.00058 20.2 0.0 1.9 1 1 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 EGD96337.1 - 0.065 13.4 0.0 0.18 11.9 0.0 1.7 2 0 0 2 2 2 0 Ferric reductase NAD binding domain Aminotran_5 PF00266.19 EGD96338.1 - 4.6e-31 108.1 0.0 3.5e-19 69.0 0.0 2.1 2 0 0 2 2 2 2 Aminotransferase class-V Aconitase PF00330.20 EGD96339.1 - 2.5e-113 379.6 0.2 2.1e-112 376.5 0.2 2.0 1 1 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 EGD96339.1 - 9.2e-24 84.2 0.0 2.3e-23 83.0 0.0 1.7 1 0 0 1 1 1 1 Aconitase C-terminal domain DUF5068 PF16781.5 EGD96339.1 - 0.043 13.6 0.0 0.087 12.6 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5068) Peptidase_M22 PF00814.25 EGD96340.1 - 3.2e-84 282.8 0.0 4.3e-84 282.4 0.0 1.2 1 0 0 1 1 1 1 Glycoprotease family Carbam_trans_N PF02543.15 EGD96340.1 - 0.1 12.2 0.1 0.45 10.1 0.1 1.8 2 0 0 2 2 2 0 Carbamoyltransferase N-terminus SET PF00856.28 EGD96341.1 - 1.1e-18 68.2 0.0 2.6e-18 67.0 0.0 1.7 1 1 0 1 1 1 1 SET domain Rubis-subs-bind PF09273.11 EGD96341.1 - 8.5e-11 42.7 0.0 2.2e-10 41.3 0.0 1.7 1 0 0 1 1 1 1 Rubisco LSMT substrate-binding FAM178 PF14816.6 EGD96341.1 - 0.02 13.9 0.0 0.03 13.3 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function, FAM178 EPL1 PF10513.9 EGD96342.1 - 2.5e-20 73.5 0.3 2.5e-20 73.5 0.3 2.6 2 1 0 2 2 2 1 Enhancer of polycomb-like EF-hand_1 PF00036.32 EGD96343.1 - 2.8e-27 92.2 12.3 8.6e-08 31.2 0.5 4.4 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 EGD96343.1 - 1.3e-22 80.0 12.0 2e-13 50.6 1.2 2.6 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 EGD96343.1 - 4.1e-20 69.9 8.3 5.6e-05 22.8 0.1 4.6 5 0 0 5 5 5 4 EF-hand domain EF-hand_5 PF13202.6 EGD96343.1 - 8.9e-18 62.9 10.6 1.9e-06 27.1 0.3 4.4 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 EGD96343.1 - 1.8e-14 53.3 8.4 6.5e-05 22.7 0.1 4.2 3 1 1 4 4 4 4 EF-hand domain pair SPARC_Ca_bdg PF10591.9 EGD96343.1 - 4.4e-06 27.0 0.0 0.009 16.3 0.0 2.3 2 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 EGD96343.1 - 6.8e-05 22.8 8.5 0.02 14.8 0.3 3.9 1 1 3 4 4 4 2 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 EGD96343.1 - 0.035 14.4 0.1 0.82 10.0 0.0 2.7 2 1 1 3 3 3 0 EF-hand domain DUF5096 PF17019.5 EGD96345.1 - 0.014 15.2 0.0 0.021 14.6 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5096) DUF3849 PF12960.7 EGD96345.1 - 0.19 11.7 0.0 0.28 11.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3849) Ribosomal_S9 PF00380.19 EGD96346.1 - 3.1e-38 131.0 0.7 6.4e-38 130.0 0.7 1.5 1 0 0 1 1 1 1 Ribosomal protein S9/S16 EF1G PF00647.19 EGD96347.1 - 2.3e-48 162.6 0.3 4e-48 161.9 0.3 1.4 1 0 0 1 1 1 1 Elongation factor 1 gamma, conserved domain GST_C PF00043.25 EGD96347.1 - 1.5e-11 44.3 0.0 3.6e-11 43.1 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EGD96347.1 - 3.1e-11 43.4 0.0 8.9e-11 42.0 0.0 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 EGD96347.1 - 1.3e-08 35.1 0.0 2.8e-08 34.0 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EGD96347.1 - 6.4e-08 32.5 0.0 1.5e-07 31.3 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EGD96347.1 - 4e-05 23.7 0.0 9.8e-05 22.5 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 EGD96347.1 - 0.00093 19.5 0.0 0.0021 18.4 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain NIF PF03031.18 EGD96348.1 - 2.5e-27 95.6 2.7 1.2e-26 93.3 2.7 2.0 1 1 0 1 1 1 1 NLI interacting factor-like phosphatase RRP36 PF06102.12 EGD96349.1 - 8e-44 149.5 36.9 8e-44 149.5 36.9 2.4 1 1 1 2 2 2 1 rRNA biogenesis protein RRP36 DUF1509 PF07420.11 EGD96351.1 - 2.2 7.2 8.7 2.1 7.2 8.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1509) Atrophin-1 PF03154.15 EGD96351.1 - 4.1 5.6 10.5 4.3 5.5 10.5 1.2 1 0 0 1 1 1 0 Atrophin-1 family AMPK1_CBM PF16561.5 EGD96354.1 - 7.7e-30 102.9 0.1 1.3e-29 102.2 0.1 1.4 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase AMPKBI PF04739.15 EGD96354.1 - 5.5e-25 87.4 3.6 7.6e-25 87.0 1.7 2.3 2 0 0 2 2 2 1 5'-AMP-activated protein kinase beta subunit, interaction domain Mannosyl_trans3 PF11051.8 EGD96356.1 - 1.4e-59 201.8 0.0 3e-33 115.3 0.0 2.3 1 1 1 2 2 2 2 Mannosyltransferase putative Glyco_transf_8 PF01501.20 EGD96356.1 - 0.016 14.7 0.2 0.046 13.3 0.0 1.8 1 1 0 1 1 1 0 Glycosyl transferase family 8 ABC1 PF03109.16 EGD96357.1 - 9e-34 116.2 0.0 2.2e-33 114.9 0.0 1.7 1 0 0 1 1 1 1 ABC1 family UreF PF01730.16 EGD96358.1 - 1.6e-22 80.5 1.7 2.1e-22 80.1 1.7 1.2 1 0 0 1 1 1 1 UreF BRE1 PF08647.11 EGD96359.1 - 2.1e-25 88.6 14.5 2.1e-25 88.6 14.5 6.8 4 2 3 7 7 7 1 BRE1 E3 ubiquitin ligase zf-C3HC4_3 PF13920.6 EGD96359.1 - 6.3e-10 38.8 8.3 1.1e-09 37.9 8.3 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EGD96359.1 - 2.6e-09 36.8 8.5 5.1e-09 35.8 8.5 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EGD96359.1 - 9.6e-08 31.8 10.8 1.8e-07 30.9 10.8 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EGD96359.1 - 1e-07 31.8 6.4 2.2e-07 30.8 6.4 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.6 EGD96359.1 - 1.1e-07 32.0 9.1 2e-07 31.2 9.1 1.5 1 0 0 1 1 1 1 Ring finger domain Prok-RING_4 PF14447.6 EGD96359.1 - 2e-07 30.8 8.6 3.6e-07 29.9 8.6 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 EGD96359.1 - 2.1e-06 27.6 11.2 3.9e-06 26.7 11.2 1.5 1 0 0 1 1 1 1 zinc-RING finger domain DUF745 PF05335.13 EGD96359.1 - 0.00042 20.1 5.7 0.00042 20.1 5.7 5.6 3 2 3 6 6 5 1 Protein of unknown function (DUF745) zf-rbx1 PF12678.7 EGD96359.1 - 0.0015 18.8 5.1 0.0046 17.2 5.1 1.9 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_4 PF15227.6 EGD96359.1 - 0.0017 18.5 7.0 0.0033 17.5 7.0 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_10 PF16685.5 EGD96359.1 - 0.019 15.1 7.3 0.048 13.8 7.3 1.7 1 0 0 1 1 1 0 zinc RING finger of MSL2 DUF1272 PF06906.11 EGD96359.1 - 0.02 15.0 6.1 0.043 13.9 6.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1272) GP41 PF00517.17 EGD96359.1 - 0.038 13.9 0.1 0.038 13.9 0.1 4.4 4 1 0 4 4 4 0 Retroviral envelope protein zf-RING_4 PF14570.6 EGD96359.1 - 0.063 13.1 7.7 0.51 10.2 8.4 2.1 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain zf-Nse PF11789.8 EGD96359.1 - 0.56 10.1 6.0 1.3 8.9 6.0 1.6 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-UDP PF14569.6 EGD96359.1 - 0.76 9.9 4.6 1.9 8.7 4.6 1.7 1 0 0 1 1 1 0 Zinc-binding RING-finger zf-H2C2_2 PF13465.6 EGD96359.1 - 0.96 10.0 3.4 3.7 8.1 0.5 2.5 2 0 0 2 2 2 0 Zinc-finger double domain zf-RING_6 PF14835.6 EGD96359.1 - 1 9.3 3.8 2 8.3 3.8 1.4 1 0 0 1 1 1 0 zf-RING of BARD1-type protein FYVE PF01363.21 EGD96359.1 - 1.8 8.8 12.7 32 4.8 11.8 2.5 1 1 1 2 2 2 0 FYVE zinc finger zf-C2HE PF16278.5 EGD96359.1 - 2.4 8.7 6.2 7.2 7.1 0.2 3.9 1 1 1 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger AAA_13 PF13166.6 EGD96359.1 - 3.4 6.2 68.7 0.64 8.6 18.4 4.0 1 1 1 4 4 4 0 AAA domain HALZ PF02183.18 EGD96359.1 - 3.6 7.9 30.8 4.7 7.5 0.5 6.6 6 0 0 6 6 6 0 Homeobox associated leucine zipper Myb_DNA-bind_4 PF13837.6 EGD96359.1 - 4.5 7.7 11.7 0.34 11.3 0.3 4.0 4 0 0 4 4 3 0 Myb/SANT-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 EGD96360.1 - 7.1e-28 96.3 0.1 7.1e-28 96.3 0.1 2.3 2 1 1 3 3 3 1 Myb DNA-binding like Myb_DNA-binding PF00249.31 EGD96360.1 - 0.00031 20.9 1.8 0.00063 19.9 0.0 2.3 3 0 0 3 3 3 1 Myb-like DNA-binding domain Maf PF02545.14 EGD96360.1 - 0.054 13.3 0.8 0.096 12.5 0.8 1.3 1 0 0 1 1 1 0 Maf-like protein SARAF PF06682.12 EGD96361.1 - 3.9e-86 289.7 9.4 8.3e-85 285.4 9.4 2.0 1 1 0 1 1 1 1 SOCE-associated regulatory factor of calcium homoeostasis MMM1 PF10296.9 EGD96362.1 - 1.3e-134 448.5 0.0 1.5e-134 448.2 0.0 1.0 1 0 0 1 1 1 1 Maintenance of mitochondrial morphology protein 1 ARD PF03079.14 EGD96363.1 - 8.1e-48 162.6 0.2 9.5e-48 162.3 0.2 1.0 1 0 0 1 1 1 1 ARD/ARD' family Cupin_2 PF07883.11 EGD96363.1 - 5.4e-09 35.6 0.1 8.6e-09 35.0 0.1 1.2 1 0 0 1 1 1 1 Cupin domain AraC_binding PF02311.19 EGD96363.1 - 3.8e-05 23.6 0.0 5.3e-05 23.1 0.0 1.2 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_1 PF00190.22 EGD96363.1 - 0.06 13.0 0.0 0.078 12.6 0.0 1.2 1 0 0 1 1 1 0 Cupin GIDA PF01134.22 EGD96364.1 - 5.5e-155 516.3 0.0 1.3e-154 515.1 0.0 1.5 2 0 0 2 2 2 1 Glucose inhibited division protein A GIDA_assoc PF13932.6 EGD96364.1 - 1.5e-65 221.3 0.0 2e-65 220.9 0.0 1.2 1 0 0 1 1 1 1 GidA associated domain FAD_oxidored PF12831.7 EGD96364.1 - 2.3e-06 27.2 0.5 3.3e-06 26.7 0.5 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EGD96364.1 - 5.1e-06 25.9 0.3 9.4e-06 25.1 0.3 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EGD96364.1 - 0.00044 19.4 1.7 0.00091 18.4 1.7 1.5 1 0 0 1 1 1 1 FAD binding domain AlaDh_PNT_C PF01262.21 EGD96364.1 - 0.021 14.1 0.1 0.042 13.2 0.1 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Trp_halogenase PF04820.14 EGD96364.1 - 0.028 13.3 0.1 3.8 6.2 0.0 2.1 2 0 0 2 2 2 0 Tryptophan halogenase HI0933_like PF03486.14 EGD96364.1 - 0.035 12.8 0.6 0.38 9.4 0.3 2.3 2 0 0 2 2 2 0 HI0933-like protein DAO PF01266.24 EGD96364.1 - 0.086 12.4 0.5 5.6 6.4 0.0 2.4 2 0 0 2 2 2 0 FAD dependent oxidoreductase DUF3605 PF12239.8 EGD96365.1 - 8e-50 169.1 2.4 1e-49 168.8 2.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3605) Phytochelatin_C PF09328.10 EGD96365.1 - 0.053 12.9 0.1 0.098 12.0 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1984) Sec1 PF00995.23 EGD96366.1 - 1.5e-134 450.4 0.1 1.8e-134 450.1 0.1 1.0 1 0 0 1 1 1 1 Sec1 family adh_short PF00106.25 EGD96367.1 - 1.8e-33 115.7 0.0 2.5e-33 115.2 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EGD96367.1 - 1.2e-24 87.2 0.0 1.6e-24 86.8 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EGD96367.1 - 1.1e-09 38.5 0.0 1.6e-09 37.9 0.0 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EGD96367.1 - 4.1e-07 29.7 0.0 1.3e-06 28.1 0.0 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 EGD96367.1 - 0.00064 18.9 0.0 0.00082 18.6 0.0 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 EGD96367.1 - 0.0012 18.0 0.0 0.0019 17.4 0.0 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_10 PF13460.6 EGD96367.1 - 0.0018 18.2 0.0 0.0026 17.7 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 EGD96367.1 - 0.02 14.5 0.0 0.045 13.3 0.0 1.6 2 0 0 2 2 2 0 NmrA-like family 3Beta_HSD PF01073.19 EGD96367.1 - 0.091 11.8 0.0 0.13 11.2 0.0 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_8 PF13450.6 EGD96368.1 - 3.9e-15 55.8 0.3 4.6e-14 52.4 0.0 2.6 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EGD96368.1 - 3.1e-09 36.9 0.0 2.1e-06 27.6 0.0 2.3 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EGD96368.1 - 3.3e-08 33.1 0.1 3.2e-05 23.3 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 EGD96368.1 - 9.3e-08 31.8 0.0 6.9e-06 25.6 0.0 2.7 2 1 0 2 2 2 1 Flavin containing amine oxidoreductase FAD_binding_2 PF00890.24 EGD96368.1 - 4.6e-06 26.0 0.2 8.3e-06 25.1 0.2 1.4 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.17 EGD96368.1 - 1.9e-05 24.0 0.0 3.7e-05 23.1 0.0 1.4 1 0 0 1 1 1 1 Thi4 family HI0933_like PF03486.14 EGD96368.1 - 2e-05 23.5 0.4 0.00016 20.5 0.1 2.1 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox PF00070.27 EGD96368.1 - 8.4e-05 23.1 0.2 0.24 12.0 0.0 2.6 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EGD96368.1 - 0.0003 20.3 0.0 0.0016 17.9 0.0 2.0 2 0 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 EGD96368.1 - 0.0011 19.0 0.4 0.021 14.8 0.0 2.8 3 0 0 3 3 3 1 FAD-NAD(P)-binding Trp_halogenase PF04820.14 EGD96368.1 - 0.0021 17.0 0.1 0.007 15.3 0.0 1.8 2 0 0 2 2 2 1 Tryptophan halogenase Pyr_redox_3 PF13738.6 EGD96368.1 - 0.0025 17.1 0.0 0.09 12.0 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 EGD96368.1 - 0.02 14.1 0.1 0.067 12.4 0.1 1.9 2 1 0 2 2 2 0 FAD binding domain Lycopene_cycl PF05834.12 EGD96368.1 - 0.026 13.6 0.1 0.04 13.0 0.1 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein GIDA PF01134.22 EGD96368.1 - 0.07 12.2 0.2 0.12 11.4 0.2 1.4 1 0 0 1 1 1 0 Glucose inhibited division protein A ApbA PF02558.16 EGD96368.1 - 0.096 12.3 0.0 0.69 9.5 0.0 2.1 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA GMC_oxred_N PF00732.19 EGD96368.1 - 0.12 11.7 0.0 11 5.3 0.0 2.1 2 0 0 2 2 2 0 GMC oxidoreductase CAP_assoc_N PF14504.6 EGD96368.1 - 0.15 11.8 0.0 0.3 10.8 0.0 1.4 1 0 0 1 1 1 0 CAP-associated N-terminal Tyr-DNA_phospho PF06087.12 EGD96369.1 - 3.7e-93 312.7 0.0 4.5e-93 312.4 0.0 1.1 1 0 0 1 1 1 1 Tyrosyl-DNA phosphodiesterase PLDc_2 PF13091.6 EGD96369.1 - 3.2e-05 23.8 0.0 0.014 15.3 0.0 2.3 2 0 0 2 2 2 2 PLD-like domain UIM PF02809.20 EGD96369.1 - 2 8.5 12.6 0.087 12.8 1.0 3.6 3 0 0 3 3 3 0 Ubiquitin interaction motif Ribosomal_60s PF00428.19 EGD96369.1 - 7.4 7.2 25.8 0.1 13.2 9.0 3.0 3 0 0 3 3 3 0 60s Acidic ribosomal protein 2-Hacid_dh_C PF02826.19 EGD96370.1 - 1e-54 184.6 0.0 1.3e-54 184.3 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EGD96370.1 - 8.9e-19 67.5 0.0 1.3e-18 67.0 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 EGD96370.1 - 8e-08 32.6 0.0 1.3e-07 31.9 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 EGD96370.1 - 0.00064 20.2 0.0 0.0012 19.4 0.0 1.4 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent ApbA PF02558.16 EGD96370.1 - 0.037 13.7 0.0 0.1 12.2 0.0 1.7 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA XdhC_C PF13478.6 EGD96370.1 - 0.053 14.0 0.0 0.096 13.2 0.0 1.4 1 0 0 1 1 1 0 XdhC Rossmann domain AlaDh_PNT_C PF01262.21 EGD96370.1 - 0.11 11.8 0.0 0.16 11.2 0.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain CFEM PF05730.11 EGD96371.1 - 1.9e-11 43.9 11.3 3.3e-11 43.1 11.3 1.4 1 0 0 1 1 1 1 CFEM domain YEATS PF03366.16 EGD96372.1 - 0.00015 21.7 0.0 0.00023 21.1 0.0 1.2 1 0 0 1 1 1 1 YEATS family Ran_BP1 PF00638.18 EGD96373.1 - 5.6e-52 175.2 2.0 9.1e-52 174.5 2.0 1.3 1 0 0 1 1 1 1 RanBP1 domain VID27_PH PF17747.1 EGD96373.1 - 0.00046 20.4 0.1 0.00062 20.0 0.1 1.2 1 0 0 1 1 1 1 VID27 PH-like domain WH1 PF00568.23 EGD96373.1 - 0.0013 18.7 0.4 0.0078 16.1 0.4 2.0 1 1 0 1 1 1 1 WH1 domain LAP1C PF05609.12 EGD96373.1 - 0.52 9.3 9.2 0.62 9.1 9.2 1.2 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Tom5 PF10642.9 EGD96373.1 - 6.2 6.9 5.3 0.91 9.6 0.5 2.2 2 0 0 2 2 2 0 Mitochondrial import receptor subunit or translocase Apolipoprotein PF01442.18 EGD96374.1 - 0.0014 18.6 6.9 0.0038 17.1 6.9 1.7 1 1 0 1 1 1 1 Apolipoprotein A1/A4/E domain S1-P1_nuclease PF02265.16 EGD96374.1 - 0.067 13.0 0.1 0.91 9.3 0.0 2.0 2 0 0 2 2 2 0 S1/P1 Nuclease SMBP PF16785.5 EGD96374.1 - 0.11 12.7 2.5 0.21 11.8 2.5 1.4 1 0 0 1 1 1 0 Small metal-binding protein ATP-synt_B PF00430.18 EGD96374.1 - 0.37 10.9 6.5 0.66 10.1 6.5 1.3 1 0 0 1 1 1 0 ATP synthase B/B' CF(0) DUF883 PF05957.13 EGD96374.1 - 0.38 11.4 5.0 0.35 11.5 3.1 1.8 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF883) YtxH PF12732.7 EGD96374.1 - 0.9 10.1 4.0 0.57 10.8 1.9 1.8 2 0 0 2 2 2 0 YtxH-like protein DivIVA PF05103.13 EGD96374.1 - 1.3 9.1 6.6 3.5 7.7 6.6 1.7 1 1 0 1 1 1 0 DivIVA protein Glyco_transf_15 PF01793.16 EGD96376.1 - 2.5e-95 319.5 13.9 8.1e-95 317.8 13.9 1.7 1 1 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase PH PF00169.29 EGD96377.1 - 4.7e-28 97.8 1.7 9.4e-14 51.8 0.1 2.2 2 0 0 2 2 2 2 PH domain PH_9 PF15410.6 EGD96377.1 - 8.1e-13 48.8 3.9 1.7e-07 31.6 0.1 3.6 2 2 0 2 2 2 2 Pleckstrin homology domain PH_11 PF15413.6 EGD96377.1 - 8.1e-08 32.6 6.0 0.0023 18.3 0.1 3.3 2 2 0 2 2 2 2 Pleckstrin homology domain PH_6 PF15406.6 EGD96377.1 - 0.00057 20.2 0.0 0.014 15.7 0.0 2.5 2 0 0 2 2 2 1 Pleckstrin homology domain PBP_N PF17093.5 EGD96377.1 - 0.00062 20.0 0.0 0.0012 19.0 0.0 1.4 1 0 0 1 1 1 1 Penicillin-binding protein N-terminus PH_13 PF16652.5 EGD96377.1 - 0.11 12.4 0.2 0.5 10.2 0.0 2.0 2 0 0 2 2 2 0 Pleckstrin homology domain PH_2 PF08458.10 EGD96377.1 - 0.27 11.6 1.9 3.3 8.1 0.1 2.6 3 0 0 3 3 3 0 Plant pleckstrin homology-like region DOT1 PF08123.13 EGD96378.1 - 1.3e-76 256.7 0.0 2e-76 256.1 0.0 1.2 1 0 0 1 1 1 1 Histone methylation protein DOT1 Methyltransf_25 PF13649.6 EGD96378.1 - 0.0011 19.7 0.0 0.0064 17.2 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain NAD_binding_10 PF13460.6 EGD96378.1 - 0.028 14.3 0.0 0.053 13.4 0.0 1.4 1 0 0 1 1 1 0 NAD(P)H-binding Methyltransf_31 PF13847.6 EGD96378.1 - 0.07 12.9 0.0 0.13 12.0 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain NmrA PF05368.13 EGD96378.1 - 0.11 12.0 0.0 0.21 11.1 0.0 1.4 1 0 0 1 1 1 0 NmrA-like family ATG16 PF08614.11 EGD96379.1 - 1e-53 182.5 18.9 1.2e-53 182.4 18.9 1.0 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) CCDC144C PF14915.6 EGD96379.1 - 0.0038 16.4 11.2 0.0038 16.4 11.2 1.4 2 0 0 2 2 2 1 CCDC144C protein coiled-coil region Golgin_A5 PF09787.9 EGD96379.1 - 0.01 15.4 9.0 0.013 15.0 9.0 1.2 1 0 0 1 1 1 0 Golgin subfamily A member 5 UPF0242 PF06785.11 EGD96379.1 - 0.022 14.9 13.3 0.069 13.2 4.5 2.3 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Sec2p PF06428.11 EGD96379.1 - 0.043 13.8 10.7 0.076 13.0 9.7 2.0 1 1 0 1 1 1 0 GDP/GTP exchange factor Sec2p DUF3496 PF12001.8 EGD96379.1 - 0.12 12.8 3.5 0.11 12.9 0.9 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3496) HAUS-augmin3 PF14932.6 EGD96379.1 - 0.14 11.8 8.6 0.14 11.7 7.8 1.5 1 1 0 1 1 1 0 HAUS augmin-like complex subunit 3 Spc7 PF08317.11 EGD96379.1 - 0.27 10.1 15.0 0.13 11.1 12.7 1.6 1 1 1 2 2 2 0 Spc7 kinetochore protein DUF4201 PF13870.6 EGD96379.1 - 0.32 10.7 12.1 0.099 12.4 9.3 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4201) SecD-TM1 PF13721.6 EGD96379.1 - 0.39 11.2 1.8 0.69 10.4 1.1 1.9 1 1 1 2 2 2 0 SecD export protein N-terminal TM region DUF948 PF06103.11 EGD96379.1 - 0.87 9.9 3.3 13 6.2 3.3 2.3 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) FAM76 PF16046.5 EGD96379.1 - 0.98 8.7 7.0 1.2 8.4 7.0 1.1 1 0 0 1 1 1 0 FAM76 protein Fez1 PF06818.15 EGD96379.1 - 1.2 9.6 13.1 2.2 8.7 6.8 2.1 1 1 1 2 2 2 0 Fez1 COG2 PF06148.11 EGD96379.1 - 1.2 9.2 7.2 0.78 9.8 1.3 2.4 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF4407 PF14362.6 EGD96379.1 - 1.5 8.1 11.5 2.4 7.4 11.5 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Sec34 PF04136.15 EGD96379.1 - 1.9 8.4 7.2 1.7 8.5 0.5 2.6 2 1 1 3 3 3 0 Sec34-like family APG6_N PF17675.1 EGD96379.1 - 2.8 8.5 17.7 0.82 10.2 12.2 2.3 1 1 1 2 2 2 0 Apg6 coiled-coil region DUF4472 PF14739.6 EGD96379.1 - 3.3 8.5 12.6 0.81 10.4 6.9 2.5 2 1 1 3 3 3 0 Domain of unknown function (DUF4472) GvpG PF05120.12 EGD96379.1 - 3.8 7.6 9.0 0.16 12.0 1.9 2.3 2 1 1 3 3 2 0 Gas vesicle protein G Exonuc_VII_L PF02601.15 EGD96379.1 - 3.9 7.0 11.7 1.8 8.0 9.1 1.5 1 1 0 2 2 2 0 Exonuclease VII, large subunit YabA PF06156.13 EGD96379.1 - 5 7.8 11.1 0.68 10.6 2.2 2.5 2 1 1 3 3 3 0 Initiation control protein YabA Ras PF00071.22 EGD96380.1 - 5.8e-56 188.6 0.2 6.9e-56 188.3 0.2 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EGD96380.1 - 1.1e-31 109.5 0.0 1.7e-31 108.9 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EGD96380.1 - 9.8e-14 51.2 0.0 1.2e-13 51.0 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EGD96380.1 - 8.9e-08 32.2 0.0 1.4e-07 31.6 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EGD96380.1 - 3e-07 30.0 0.1 3.8e-07 29.7 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EGD96380.1 - 1.3e-06 28.1 0.0 4.1e-05 23.2 0.0 2.2 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EGD96380.1 - 8.3e-05 22.5 0.2 0.0031 17.5 0.1 2.4 1 1 2 3 3 3 1 RsgA GTPase PduV-EutP PF10662.9 EGD96380.1 - 0.0028 17.4 0.1 0.084 12.6 0.0 2.2 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation cobW PF02492.19 EGD96380.1 - 0.0042 16.7 0.0 0.014 15.0 0.0 1.7 1 1 2 3 3 3 1 CobW/HypB/UreG, nucleotide-binding domain AAA_5 PF07728.14 EGD96380.1 - 0.0079 16.2 0.0 0.016 15.2 0.0 1.7 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) ATP_bind_1 PF03029.17 EGD96380.1 - 0.0085 15.9 0.3 0.24 11.1 0.0 2.1 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein AAA_22 PF13401.6 EGD96380.1 - 0.0088 16.3 0.0 0.017 15.4 0.0 1.6 1 1 0 1 1 1 1 AAA domain Septin PF00735.18 EGD96380.1 - 0.0091 15.3 0.5 0.047 13.0 0.0 2.2 3 0 0 3 3 3 1 Septin AAA_16 PF13191.6 EGD96380.1 - 0.011 16.2 0.0 0.015 15.6 0.0 1.6 1 1 0 1 1 1 0 AAA ATPase domain SRPRB PF09439.10 EGD96380.1 - 0.012 15.1 0.0 0.016 14.6 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_7 PF12775.7 EGD96380.1 - 0.017 14.7 0.1 0.034 13.7 0.1 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_24 PF13479.6 EGD96380.1 - 0.023 14.4 0.3 0.054 13.2 0.1 1.7 2 0 0 2 2 2 0 AAA domain ATPase_2 PF01637.18 EGD96380.1 - 0.06 13.3 1.2 0.11 12.4 0.1 1.8 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea NTPase_1 PF03266.15 EGD96380.1 - 0.062 13.2 0.0 0.097 12.6 0.0 1.3 1 0 0 1 1 1 0 NTPase TniB PF05621.11 EGD96380.1 - 0.079 12.4 0.0 0.12 11.8 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein NACHT PF05729.12 EGD96380.1 - 0.12 12.3 0.0 0.18 11.7 0.0 1.3 1 0 0 1 1 1 0 NACHT domain ABC_tran PF00005.27 EGD96380.1 - 0.18 12.3 0.1 0.39 11.2 0.0 1.6 2 0 0 2 2 2 0 ABC transporter EamA PF00892.20 EGD96381.1 - 2.2e-10 40.8 35.4 1.4e-07 31.8 4.8 3.1 3 0 0 3 3 3 2 EamA-like transporter family SLC35F PF06027.12 EGD96381.1 - 1.7e-07 31.0 10.1 1.7e-07 31.0 10.1 1.9 2 0 0 2 2 2 1 Solute carrier family 35 PUNUT PF16913.5 EGD96381.1 - 1.7e-05 24.2 0.5 1.7e-05 24.2 0.5 1.7 2 0 0 2 2 2 1 Purine nucleobase transmembrane transport DUF3955 PF13127.6 EGD96381.1 - 0.00035 20.3 0.9 0.00035 20.3 0.9 4.1 5 2 1 6 6 6 1 Protein of unknown function (DUF3955) UAA PF08449.11 EGD96381.1 - 0.031 13.5 13.9 0.0057 15.9 10.4 1.5 2 0 0 2 2 2 0 UAA transporter family DUF2981 PF11200.8 EGD96381.1 - 0.062 13.1 0.0 0.1 12.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2981) Spb1_C PF07780.12 EGD96382.1 - 8.3e-85 283.7 19.2 8.3e-85 283.7 19.2 2.7 3 1 0 3 3 3 1 Spb1 C-terminal domain FtsJ PF01728.19 EGD96382.1 - 2.6e-55 187.2 0.0 5e-55 186.3 0.0 1.5 1 0 0 1 1 1 1 FtsJ-like methyltransferase DUF3381 PF11861.8 EGD96382.1 - 1.5e-51 174.5 9.7 1.5e-51 174.5 9.7 4.5 4 1 0 5 5 5 1 Domain of unknown function (DUF3381) Methyltransf_23 PF13489.6 EGD96382.1 - 0.0044 16.9 0.0 0.014 15.3 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltr_RsmB-F PF01189.17 EGD96382.1 - 0.058 13.0 0.0 0.14 11.8 0.0 1.6 1 0 0 1 1 1 0 16S rRNA methyltransferase RsmB/F KCT2 PF17818.1 EGD96382.1 - 4.3 7.4 12.5 10 6.2 3.6 2.5 2 0 0 2 2 2 0 Keratinocyte-associated gene product PcfJ PF14284.6 EGD96382.1 - 5.1 7.0 7.4 0.5 10.2 1.5 2.4 2 0 0 2 2 2 0 PcfJ-like protein Zn_clus PF00172.18 EGD96384.1 - 4.1e-07 30.0 10.5 8.1e-07 29.1 10.5 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EGD96384.1 - 0.002 17.2 0.0 0.0034 16.4 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain EF-hand_4 PF12763.7 EGD96386.1 - 0.00085 19.2 0.1 0.0016 18.4 0.1 1.3 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand Pkinase PF00069.25 EGD96387.1 - 7.2e-70 235.3 0.0 9.1e-70 235.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD96387.1 - 6.1e-33 114.2 0.0 8.3e-33 113.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.24 EGD96387.1 - 1.9e-09 38.1 2.5 4.8e-09 36.8 2.5 1.8 1 0 0 1 1 1 1 Protein kinase C terminal domain Haspin_kinase PF12330.8 EGD96387.1 - 9.7e-06 24.7 0.1 1.5e-05 24.1 0.1 1.3 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 EGD96387.1 - 0.042 13.2 0.0 0.077 12.3 0.0 1.4 1 0 0 1 1 1 0 Kinase-like FTA2 PF13095.6 EGD96387.1 - 0.072 12.7 0.1 0.81 9.3 0.1 2.1 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 DNA_ligase_A_M PF01068.21 EGD96388.1 - 4.9e-48 163.5 0.0 4.5e-47 160.3 0.0 2.5 3 0 0 3 3 3 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 EGD96388.1 - 3.8e-41 141.3 0.0 1e-40 139.9 0.0 1.8 2 0 0 2 2 2 1 DNA ligase N terminus BRCT_2 PF16589.5 EGD96388.1 - 7.7e-22 77.5 0.1 1.7e-14 54.0 0.1 2.6 2 0 0 2 2 2 2 BRCT domain, a BRCA1 C-terminus domain RNA_ligase PF09414.10 EGD96388.1 - 8.4e-19 68.4 0.0 1.9e-18 67.3 0.0 1.6 1 0 0 1 1 1 1 RNA ligase DNA_ligase_A_C PF04679.15 EGD96388.1 - 3.9e-17 62.7 0.0 1.2e-16 61.1 0.0 1.9 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region BRCT PF00533.26 EGD96388.1 - 7.1e-10 39.1 0.1 1.7e-06 28.3 0.1 2.8 2 0 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain LIG3_BRCT PF16759.5 EGD96388.1 - 4.5e-08 33.3 2.1 0.0011 19.2 0.0 2.8 2 1 0 2 2 2 2 DNA ligase 3 BRCT domain RTT107_BRCT_5 PF16770.5 EGD96388.1 - 0.0032 17.3 0.0 1 9.3 0.0 2.4 2 0 0 2 2 2 2 Regulator of Ty1 transposition protein 107 BRCT domain Fungal_trans PF04082.18 EGD96389.1 - 1.5e-45 155.3 0.0 3e-45 154.3 0.0 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EGD96389.1 - 4.6e-08 33.1 9.1 9e-08 32.1 9.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PHD PF00628.29 EGD96389.1 - 0.0076 16.1 4.7 0.019 14.9 4.7 1.7 1 0 0 1 1 1 1 PHD-finger MnmE_helical PF12631.7 EGD96389.1 - 0.1 12.7 0.0 0.14 12.3 0.0 1.3 1 0 0 1 1 1 0 MnmE helical domain Metallophos PF00149.28 EGD96390.1 - 1.1e-31 111.0 0.0 4.6e-22 79.5 0.0 2.1 1 1 1 2 2 2 2 Calcineurin-like phosphoesterase STPPase_N PF16891.5 EGD96390.1 - 0.088 13.3 0.1 0.23 11.9 0.1 1.7 1 0 0 1 1 1 0 Serine-threonine protein phosphatase N-terminal domain COA2 PF17051.5 EGD96391.1 - 0.0086 16.1 0.0 0.021 14.9 0.0 1.7 1 0 0 1 1 1 1 Cytochrome C oxidase assembly factor 2 DUF4646 PF15496.6 EGD96392.1 - 3.3e-19 69.7 0.0 5.3e-19 69.1 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4646) ALG3 PF05208.13 EGD96393.1 - 6e-138 460.2 21.0 6.9e-138 459.9 21.0 1.0 1 0 0 1 1 1 1 ALG3 protein CRPA PF05745.11 EGD96393.1 - 0.46 10.5 2.6 6.7 6.7 0.3 3.1 2 1 1 3 3 3 0 Chlamydia 15 kDa cysteine-rich outer membrane protein (CRPA) eIF-1a PF01176.19 EGD96394.1 - 1e-19 70.1 0.1 1.5e-19 69.6 0.1 1.2 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 Pkinase PF00069.25 EGD96395.1 - 2.8e-60 203.9 0.0 6e-60 202.8 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD96395.1 - 3.8e-35 121.4 0.0 6.8e-35 120.6 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase HR1 PF02185.16 EGD96395.1 - 3e-29 100.9 14.1 3e-15 56.1 4.5 2.6 2 0 0 2 2 2 2 Hr1 repeat C1_1 PF00130.22 EGD96395.1 - 1.8e-20 72.5 27.8 8.3e-12 44.8 9.0 2.4 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) Pkinase_C PF00433.24 EGD96395.1 - 1.5e-14 54.4 1.7 8.3e-14 52.0 1.7 2.4 2 0 0 2 2 2 1 Protein kinase C terminal domain C2 PF00168.30 EGD96395.1 - 1.5e-07 31.7 0.0 3.1e-07 30.6 0.0 1.5 1 0 0 1 1 1 1 C2 domain Kinase-like PF14531.6 EGD96395.1 - 0.028 13.8 0.0 0.049 13.0 0.0 1.3 1 0 0 1 1 1 0 Kinase-like zf-RING_9 PF13901.6 EGD96395.1 - 2.7 7.9 22.2 1.6 8.7 7.7 2.4 2 0 0 2 2 2 0 Putative zinc-RING and/or ribbon TFIIA PF03153.13 EGD96395.1 - 5.9 6.8 32.3 1 9.3 28.0 1.8 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit TFCD_C PF12612.8 EGD96397.1 - 3.6e-33 115.0 0.0 8e-33 113.9 0.0 1.6 1 0 0 1 1 1 1 Tubulin folding cofactor D C terminal HEAT PF02985.22 EGD96397.1 - 8.8e-06 25.6 0.3 1.5 9.3 0.0 5.6 6 0 0 6 6 6 2 HEAT repeat HEAT_2 PF13646.6 EGD96397.1 - 0.0031 17.9 1.7 0.54 10.7 0.2 3.9 4 0 0 4 4 4 1 HEAT repeats HEAT_EZ PF13513.6 EGD96397.1 - 0.0039 17.7 2.1 2 9.0 0.0 4.3 4 0 0 4 4 4 1 HEAT-like repeat Vac14_Fab1_bd PF12755.7 EGD96397.1 - 0.11 13.1 0.0 2.8 8.6 0.0 3.3 2 0 0 2 2 2 0 Vacuolar 14 Fab1-binding region RRM_1 PF00076.22 EGD96398.1 - 3e-27 94.2 0.5 2.3e-12 46.6 0.2 2.6 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EGD96398.1 - 0.0012 18.4 0.0 0.023 14.3 0.0 2.1 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PHM7_cyt PF14703.6 EGD96398.1 - 2.1 8.6 4.2 14 5.9 0.1 3.2 2 2 1 3 3 3 0 Cytosolic domain of 10TM putative phosphate transporter ATP-synt_D PF01813.17 EGD96399.1 - 6.7e-71 238.2 0.9 9.7e-71 237.7 0.9 1.2 1 0 0 1 1 1 1 ATP synthase subunit D SYCE1 PF15233.6 EGD96399.1 - 0.0035 17.4 1.6 0.017 15.2 0.5 2.2 2 0 0 2 2 2 1 Synaptonemal complex central element protein 1 HtrL_YibB PF09612.10 EGD96399.1 - 0.049 13.1 0.3 0.077 12.5 0.3 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (HtrL_YibB) DUF3919 PF13057.6 EGD96399.1 - 0.061 12.9 0.6 0.09 12.3 0.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3919) TPR_14 PF13428.6 EGD96400.1 - 2.9e-15 55.7 11.7 1.4 10.0 0.0 11.7 9 2 3 12 12 12 3 Tetratricopeptide repeat Suf PF05843.14 EGD96400.1 - 3.4e-11 43.7 10.7 0.0059 16.6 0.2 5.9 3 1 2 5 5 5 4 Suppressor of forked protein (Suf) TPR_19 PF14559.6 EGD96400.1 - 2.8e-08 34.2 1.2 0.56 10.8 0.0 6.3 7 0 0 7 7 6 1 Tetratricopeptide repeat TPR_8 PF13181.6 EGD96400.1 - 5e-08 32.5 4.4 0.33 11.3 0.0 6.9 7 0 0 7 7 7 2 Tetratricopeptide repeat Mad3_BUB1_I PF08311.12 EGD96400.1 - 9.5e-07 28.8 11.7 0.88 9.6 0.1 7.2 6 2 1 7 7 7 2 Mad3/BUB1 homology region 1 TPR_12 PF13424.6 EGD96400.1 - 9.8e-07 29.0 4.2 29 5.0 0.0 7.2 6 1 0 6 6 6 0 Tetratricopeptide repeat TPR_15 PF13429.6 EGD96400.1 - 2.1e-06 27.2 4.8 0.00042 19.6 0.2 4.3 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_2 PF07719.17 EGD96400.1 - 1.1e-05 25.2 12.9 1.1 9.6 0.0 7.5 8 0 0 8 8 7 1 Tetratricopeptide repeat TPR_17 PF13431.6 EGD96400.1 - 0.00049 20.3 3.1 1.3 9.6 0.0 6.7 8 0 0 8 8 6 1 Tetratricopeptide repeat TPR_1 PF00515.28 EGD96400.1 - 0.0024 17.6 0.0 5 7.1 0.0 4.4 3 0 0 3 3 3 1 Tetratricopeptide repeat HAT PF02184.16 EGD96400.1 - 0.0039 17.1 3.0 2.1 8.4 0.1 5.4 5 0 0 5 5 4 1 HAT (Half-A-TPR) repeat TPR_11 PF13414.6 EGD96400.1 - 0.041 13.6 0.1 0.52 10.0 0.1 3.1 3 1 0 3 3 3 0 TPR repeat TPR_10 PF13374.6 EGD96400.1 - 0.15 11.9 9.1 61 3.7 0.0 6.9 8 0 0 8 8 8 0 Tetratricopeptide repeat PPR PF01535.20 EGD96400.1 - 0.26 11.6 0.8 1.4e+02 3.0 0.0 4.5 4 0 0 4 4 4 0 PPR repeat NRDE-2 PF08424.10 EGD96400.1 - 1 8.4 15.3 0.086 12.0 0.5 5.9 3 3 2 5 5 5 0 NRDE-2, necessary for RNA interference Sec7 PF01369.20 EGD96401.1 - 2.4e-60 203.4 0.0 3.8e-60 202.7 0.0 1.3 1 0 0 1 1 1 1 Sec7 domain Sec7_N PF12783.7 EGD96401.1 - 2.5e-22 79.5 0.0 5.1e-20 72.0 0.0 3.5 3 0 0 3 3 3 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DCB PF16213.5 EGD96401.1 - 0.0019 17.9 0.8 0.0068 16.1 0.8 2.0 1 0 0 1 1 1 1 Dimerisation and cyclophilin-binding domain of Mon2 RhoGEF PF00621.20 EGD96403.1 - 2.9e-19 70.0 0.0 5.5e-19 69.1 0.0 1.5 1 0 0 1 1 1 1 RhoGEF domain DUF3507 PF12015.8 EGD96403.1 - 0.00013 21.8 0.0 0.00024 20.9 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3507) Nod1 PF17114.5 EGD96403.1 - 0.036 14.2 0.0 0.85 9.8 0.0 2.7 2 0 0 2 2 2 0 Gef2-related medial cortical node protein Nod1 OmpH PF03938.14 EGD96403.1 - 4.7 7.6 5.5 1.5 9.2 1.7 2.0 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Exonuc_VII_L PF02601.15 EGD96403.1 - 7.2 6.1 8.4 18 4.8 8.4 1.7 1 0 0 1 1 1 0 Exonuclease VII, large subunit ATP_bind_3 PF01171.20 EGD96404.1 - 1.4e-42 145.5 0.0 5.2e-42 143.7 0.0 1.9 1 1 0 1 1 1 1 PP-loop family NAD_synthase PF02540.17 EGD96404.1 - 0.013 14.6 0.0 0.096 11.8 0.0 2.1 2 0 0 2 2 2 0 NAD synthase Mito_carr PF00153.27 EGD96405.1 - 4.6e-45 151.5 3.2 8.8e-20 70.4 0.1 3.7 3 1 0 3 3 3 3 Mitochondrial carrier protein DUF3337 PF11816.8 EGD96406.1 - 8.1e-56 188.6 0.0 1.8e-55 187.5 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3337) WD40 PF00400.32 EGD96406.1 - 7.2e-21 74.1 18.3 9.8e-05 23.1 0.3 6.7 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EGD96406.1 - 8.8e-05 22.7 0.4 0.23 11.8 0.0 3.2 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EGD96406.1 - 0.00061 18.6 2.5 0.016 13.9 0.1 2.8 3 0 0 3 3 3 2 Nucleoporin Nup120/160 PALB2_WD40 PF16756.5 EGD96406.1 - 0.18 10.7 0.9 3.2 6.6 0.4 2.7 2 1 1 3 3 3 0 Partner and localizer of BRCA2 WD40 domain Pkinase PF00069.25 EGD96407.1 - 2.4e-47 161.5 0.0 1.3e-46 159.2 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD96407.1 - 1.1e-21 77.4 0.0 1.6e-21 76.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EGD96407.1 - 0.0029 17.6 0.0 0.0057 16.6 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kinase-like PF14531.6 EGD96407.1 - 0.0073 15.7 0.0 0.016 14.5 0.0 1.6 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 EGD96407.1 - 0.022 13.7 0.0 0.047 12.6 0.0 1.4 1 0 0 1 1 1 0 Haspin like kinase domain Kdo PF06293.14 EGD96407.1 - 0.09 12.1 0.0 0.16 11.3 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Ribosomal_L11 PF00298.19 EGD96408.1 - 3.9e-27 94.5 0.1 6.1e-27 93.9 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain Ribosomal_L11_N PF03946.14 EGD96408.1 - 3.5e-13 49.2 0.6 6.3e-13 48.4 0.6 1.5 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Svf1_C PF17187.4 EGD96409.1 - 2.5e-57 193.3 0.0 5.8e-57 192.1 0.0 1.6 1 0 0 1 1 1 1 Svf1-like C-terminal lipocalin-like domain Svf1 PF08622.10 EGD96409.1 - 2.2e-54 183.9 0.0 3.2e-54 183.4 0.0 1.2 1 0 0 1 1 1 1 Svf1-like N-terminal lipocalin domain MFMR PF07777.11 EGD96409.1 - 0.14 12.6 0.8 1.9 9.0 0.0 3.0 2 1 1 3 3 3 0 G-box binding protein MFMR DUF3853 PF12964.7 EGD96410.1 - 0.01 16.0 0.1 0.012 15.8 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3853) AAA_6 PF12774.7 EGD96412.1 - 4.4e-87 292.1 0.1 4.3e-86 288.9 0.0 2.8 3 0 0 3 3 3 1 Hydrolytic ATP binding site of dynein motor region AAA_9 PF12781.7 EGD96412.1 - 9.8e-75 250.5 1.1 9.8e-75 250.5 1.1 4.5 5 1 1 6 6 5 1 ATP-binding dynein motor region AAA_8 PF12780.7 EGD96412.1 - 1.5e-66 224.4 0.0 7.6e-66 222.1 0.0 2.3 2 0 0 2 2 2 1 P-loop containing dynein motor region D4 AAA_7 PF12775.7 EGD96412.1 - 1.6e-41 141.8 0.0 8.7e-37 126.4 0.0 4.0 4 0 0 4 4 3 2 P-loop containing dynein motor region MT PF12777.7 EGD96412.1 - 1.8e-39 135.8 6.8 2.7e-39 135.2 6.8 1.2 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_5 PF07728.14 EGD96412.1 - 1.3e-33 115.9 0.0 4.3e-11 43.0 0.0 5.9 5 0 0 5 5 5 4 AAA domain (dynein-related subfamily) Dynein_heavy PF03028.15 EGD96412.1 - 9.8e-32 109.5 0.0 2.7e-27 95.2 0.0 3.2 3 0 0 3 3 2 2 Dynein heavy chain region D6 P-loop domain AAA_lid_11 PF18198.1 EGD96412.1 - 3.2e-22 79.1 0.0 8.1e-22 77.8 0.0 1.7 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain Dynein_AAA_lid PF17852.1 EGD96412.1 - 3.6e-19 69.1 0.1 8.4e-17 61.5 0.0 2.7 2 0 0 2 2 2 1 Dynein heavy chain AAA lid domain AAA PF00004.29 EGD96412.1 - 1.6e-12 48.0 0.0 0.0002 21.8 0.0 3.8 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 EGD96412.1 - 8.1e-11 42.3 1.3 0.05 13.8 0.0 4.7 4 0 0 4 4 4 3 AAA domain AAA_22 PF13401.6 EGD96412.1 - 9.8e-11 42.1 7.8 0.0042 17.4 0.0 5.5 5 1 0 5 5 4 2 AAA domain AAA_18 PF13238.6 EGD96412.1 - 9.1e-10 39.2 0.5 0.04 14.5 0.0 4.9 4 0 0 4 4 4 2 AAA domain AAA_16 PF13191.6 EGD96412.1 - 1e-09 39.0 0.1 0.59 10.5 0.0 6.0 6 0 0 6 6 4 2 AAA ATPase domain AAA_lid_1 PF17857.1 EGD96412.1 - 3.5e-07 30.3 1.5 4.7e-05 23.5 0.0 3.8 4 0 0 4 4 2 1 AAA+ lid domain ABC_tran PF00005.27 EGD96412.1 - 7.3e-06 26.5 0.5 1.3 9.6 0.0 4.7 4 0 0 4 4 3 2 ABC transporter Mg_chelatase PF01078.21 EGD96412.1 - 8.2e-06 25.3 1.0 0.35 10.2 0.0 3.9 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI T2SSE PF00437.20 EGD96412.1 - 1.3e-05 24.4 0.0 0.018 14.1 0.0 2.8 3 0 0 3 3 3 2 Type II/IV secretion system protein AAA_14 PF13173.6 EGD96412.1 - 3e-05 24.1 0.0 0.9 9.6 0.0 4.2 3 0 0 3 3 3 1 AAA domain AAA_29 PF13555.6 EGD96412.1 - 7e-05 22.5 0.1 1.2 9.0 0.0 3.7 3 0 0 3 3 3 1 P-loop containing region of AAA domain AAA_19 PF13245.6 EGD96412.1 - 0.00025 21.4 0.2 0.14 12.5 0.0 3.6 3 0 0 3 3 3 1 AAA domain RsgA_GTPase PF03193.16 EGD96412.1 - 0.00029 20.8 0.0 6.2 6.7 0.0 3.7 3 0 0 3 3 3 0 RsgA GTPase FtsK_SpoIIIE PF01580.18 EGD96412.1 - 0.00082 18.8 2.9 1.1 8.6 0.0 4.0 4 0 0 4 4 4 1 FtsK/SpoIIIE family AAA_25 PF13481.6 EGD96412.1 - 0.00095 18.8 0.1 0.17 11.5 0.0 3.1 3 0 0 3 3 2 1 AAA domain Zeta_toxin PF06414.12 EGD96412.1 - 0.0011 18.3 0.6 2 7.7 0.2 4.0 4 0 0 4 4 4 1 Zeta toxin IstB_IS21 PF01695.17 EGD96412.1 - 0.0015 18.3 0.1 0.31 10.8 0.0 3.5 3 0 0 3 3 3 1 IstB-like ATP binding protein Rad17 PF03215.15 EGD96412.1 - 0.0049 16.8 0.0 3.4 7.5 0.0 3.6 3 0 0 3 3 3 1 Rad17 P-loop domain DUF4482 PF14818.6 EGD96412.1 - 0.02 15.7 10.7 11 6.8 9.8 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4482) RNA_helicase PF00910.22 EGD96412.1 - 0.029 14.7 0.1 17 5.9 0.0 3.7 3 0 0 3 3 3 0 RNA helicase AAA_24 PF13479.6 EGD96412.1 - 0.03 14.1 0.2 5.7 6.6 0.0 3.2 3 0 0 3 3 3 0 AAA domain PduV-EutP PF10662.9 EGD96412.1 - 0.05 13.3 1.2 6 6.6 0.1 4.0 4 0 0 4 4 4 0 Ethanolamine utilisation - propanediol utilisation RuvB_N PF05496.12 EGD96412.1 - 0.073 12.8 0.0 3 7.6 0.0 2.7 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain ERM PF00769.19 EGD96412.1 - 0.092 12.5 24.7 0.96 9.2 14.7 2.8 3 0 0 3 3 3 0 Ezrin/radixin/moesin family NACHT PF05729.12 EGD96412.1 - 0.097 12.6 2.4 17 5.3 0.0 3.9 3 0 0 3 3 3 0 NACHT domain DUF3450 PF11932.8 EGD96412.1 - 0.12 11.7 14.9 0.53 9.5 1.0 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) 3-alpha PF03475.14 EGD96412.1 - 0.16 11.9 0.3 0.45 10.4 0.3 1.8 1 0 0 1 1 1 0 3-alpha domain AAA_17 PF13207.6 EGD96412.1 - 0.18 12.2 6.7 77 3.7 0.0 4.8 4 0 0 4 4 4 0 AAA domain AAA_28 PF13521.6 EGD96412.1 - 0.5 10.6 2.7 36 4.6 0.0 4.0 4 1 1 5 5 3 0 AAA domain Spc7 PF08317.11 EGD96412.1 - 0.53 9.1 31.9 0.037 12.9 13.8 3.4 3 0 0 3 3 3 0 Spc7 kinetochore protein AAA_11 PF13086.6 EGD96412.1 - 0.8 9.4 0.0 0.8 9.4 0.0 3.6 4 0 0 4 4 3 0 AAA domain V_ATPase_I PF01496.19 EGD96412.1 - 0.97 7.3 14.5 1.9 6.3 14.5 1.4 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family NTPase_1 PF03266.15 EGD96412.1 - 0.99 9.3 6.3 32 4.4 0.0 4.2 5 0 0 5 5 4 0 NTPase cobW PF02492.19 EGD96412.1 - 1.2 8.7 3.1 28 4.3 0.0 3.5 4 0 0 4 4 3 0 CobW/HypB/UreG, nucleotide-binding domain Phage_GP20 PF06810.11 EGD96412.1 - 1.4 8.7 21.2 2.5 7.9 9.6 3.9 4 0 0 4 4 2 0 Phage minor structural protein GP20 DUF3867 PF12983.7 EGD96412.1 - 1.7 8.7 9.9 0.27 11.3 0.5 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3867) DUF724 PF05266.14 EGD96412.1 - 3.3 7.5 17.5 0.45 10.3 0.4 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF724) CLZ PF16526.5 EGD96412.1 - 9.9 6.6 13.1 0.094 13.1 1.2 3.2 2 1 0 2 2 1 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels DHC_N1 PF08385.12 EGD96413.1 - 3.8e-119 398.9 7.4 3.8e-119 398.9 7.4 3.2 3 1 1 4 4 4 1 Dynein heavy chain, N-terminal region 1 DHC_N2 PF08393.13 EGD96413.1 - 1.1e-116 390.2 14.7 1.5e-116 389.8 2.8 3.9 3 1 0 3 3 3 2 Dynein heavy chain, N-terminal region 2 MEDS PF14417.6 EGD96413.1 - 0.03 14.1 0.4 0.15 11.9 0.1 2.5 2 0 0 2 2 2 0 MEDS: MEthanogen/methylotroph, DcmR Sensory domain DUF2894 PF11445.8 EGD96413.1 - 0.086 13.3 4.9 0.77 10.2 1.1 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2894) HrpB7 PF09486.10 EGD96413.1 - 0.21 11.9 3.3 4 7.8 3.0 3.0 2 0 0 2 2 2 0 Bacterial type III secretion protein (HrpB7) Ribonuclease_3 PF00636.26 EGD96414.1 - 1.2e-40 138.4 0.0 1.5e-19 70.6 0.0 2.8 2 0 0 2 2 2 2 Ribonuclease III domain Ribonucleas_3_3 PF14622.6 EGD96414.1 - 2.4e-23 82.7 0.0 3.1e-12 46.8 0.0 3.4 2 1 0 2 2 2 2 Ribonuclease-III-like Dicer_dimer PF03368.14 EGD96414.1 - 7.6e-21 74.1 0.2 1.1e-18 67.1 0.1 3.0 1 1 1 2 2 2 1 Dicer dimerisation domain ResIII PF04851.15 EGD96414.1 - 3.4e-16 59.7 0.3 8.7e-16 58.4 0.3 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EGD96414.1 - 1.1e-13 51.5 0.2 5.5e-13 49.2 0.2 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 EGD96414.1 - 6.1e-10 39.1 0.0 1.3e-09 38.1 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase dsrm PF00035.26 EGD96414.1 - 0.0028 18.3 0.1 0.83 10.4 0.0 2.8 2 0 0 2 2 2 1 Double-stranded RNA binding motif AAA_22 PF13401.6 EGD96414.1 - 0.072 13.4 0.1 0.36 11.1 0.0 2.2 2 0 0 2 2 2 0 AAA domain TrbI_Ftype PF09677.10 EGD96414.1 - 0.072 13.4 0.0 0.24 11.7 0.0 1.9 1 0 0 1 1 1 0 Type-F conjugative transfer system protein (TrbI_Ftype) TAP42 PF04177.12 EGD96415.1 - 7.3e-43 146.9 12.6 1.8e-41 142.4 7.9 2.0 1 1 1 2 2 2 2 TAP42-like family Sas6_CC PF18594.1 EGD96415.1 - 3.9 7.4 7.8 3.1 7.6 1.0 2.9 2 0 0 2 2 2 0 Sas6/XLF/XRCC4 coiled-coil domain Lipase_GDSL_2 PF13472.6 EGD96416.1 - 4.7e-14 53.2 0.0 5.6e-13 49.7 0.0 2.3 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 EGD96416.1 - 3.9e-13 49.8 0.0 6.8e-13 49.0 0.0 1.4 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase PRP21_like_P PF12230.8 EGD96416.1 - 0.18 11.6 0.0 0.31 10.9 0.0 1.2 1 0 0 1 1 1 0 Pre-mRNA splicing factor PRP21 like protein Porphobil_deam PF01379.20 EGD96417.1 - 9.4e-74 247.3 0.1 1.3e-73 246.9 0.1 1.2 1 0 0 1 1 1 1 Porphobilinogen deaminase, dipyromethane cofactor binding domain Porphobil_deamC PF03900.15 EGD96417.1 - 9e-19 67.6 0.5 1.6e-18 66.9 0.5 1.4 1 0 0 1 1 1 1 Porphobilinogen deaminase, C-terminal domain DUF1534 PF07551.11 EGD96417.1 - 0.16 11.7 0.1 1.9 8.3 0.0 2.7 3 1 0 3 3 3 0 Protein of unknown function (DUF1534) Lon_C PF05362.13 EGD96418.1 - 7e-69 231.5 0.3 1.4e-68 230.5 0.3 1.5 1 0 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain AAA PF00004.29 EGD96418.1 - 4.4e-24 85.4 0.0 3.2e-23 82.6 0.0 2.5 3 0 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) LON_substr_bdg PF02190.16 EGD96418.1 - 9.8e-23 81.1 0.1 2.6e-22 79.7 0.0 1.7 2 0 0 2 2 2 1 ATP-dependent protease La (LON) substrate-binding domain AAA_5 PF07728.14 EGD96418.1 - 1e-07 32.0 0.0 3.7e-07 30.2 0.0 2.0 2 0 0 2 2 1 1 AAA domain (dynein-related subfamily) ChlI PF13541.6 EGD96418.1 - 2.4e-07 30.6 0.0 5.1e-07 29.6 0.0 1.6 1 0 0 1 1 1 1 Subunit ChlI of Mg-chelatase AAA_16 PF13191.6 EGD96418.1 - 2e-06 28.3 0.1 1e-05 26.0 0.1 2.2 1 0 0 1 1 1 1 AAA ATPase domain IstB_IS21 PF01695.17 EGD96418.1 - 7.6e-06 25.8 0.0 2.2e-05 24.3 0.0 1.8 1 0 0 1 1 1 1 IstB-like ATP binding protein TIP49 PF06068.13 EGD96418.1 - 2e-05 24.0 0.0 4.4e-05 22.9 0.0 1.5 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_3 PF07726.11 EGD96418.1 - 6.6e-05 22.8 0.0 0.00018 21.3 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 EGD96418.1 - 0.00032 20.5 0.1 0.0012 18.6 0.0 2.0 2 0 0 2 2 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 EGD96418.1 - 0.00064 19.9 0.0 0.0039 17.3 0.0 2.5 1 1 1 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 EGD96418.1 - 0.001 19.4 0.2 0.011 16.0 0.0 2.7 2 1 1 3 3 2 1 AAA domain Birna_VP4 PF01768.16 EGD96418.1 - 0.0052 16.6 0.0 0.011 15.5 0.0 1.6 1 0 0 1 1 1 1 Birnavirus VP4 protein AAA_33 PF13671.6 EGD96418.1 - 0.0063 16.7 0.0 0.015 15.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 EGD96418.1 - 0.012 16.0 0.0 0.054 13.9 0.0 2.2 1 0 0 1 1 1 0 RNA helicase AAA_14 PF13173.6 EGD96418.1 - 0.013 15.5 0.0 0.047 13.7 0.0 2.0 1 0 0 1 1 1 0 AAA domain Rad17 PF03215.15 EGD96418.1 - 0.015 15.2 0.1 0.08 12.9 0.0 2.1 2 0 0 2 2 2 0 Rad17 P-loop domain AAA_7 PF12775.7 EGD96418.1 - 0.02 14.4 0.0 0.038 13.5 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region Mg_chelatase PF01078.21 EGD96418.1 - 0.022 14.1 0.1 0.058 12.8 0.1 1.6 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 EGD96418.1 - 0.026 15.1 0.1 0.085 13.4 0.1 1.9 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 EGD96418.1 - 0.035 14.0 0.0 0.12 12.3 0.0 1.9 1 0 0 1 1 1 0 NACHT domain AAA_19 PF13245.6 EGD96418.1 - 0.038 14.3 0.6 0.21 11.9 0.3 2.5 2 1 0 2 2 1 0 AAA domain TniB PF05621.11 EGD96418.1 - 0.038 13.4 0.0 0.19 11.1 0.0 2.2 2 0 0 2 2 2 0 Bacterial TniB protein PhoH PF02562.16 EGD96418.1 - 0.043 13.3 0.0 0.11 11.9 0.0 1.6 1 0 0 1 1 1 0 PhoH-like protein TsaE PF02367.17 EGD96418.1 - 0.049 13.6 0.0 0.15 12.1 0.0 1.8 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_25 PF13481.6 EGD96418.1 - 0.058 13.0 0.0 0.14 11.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_PrkA PF08298.11 EGD96418.1 - 0.067 12.1 0.1 0.18 10.7 0.1 1.6 1 1 0 1 1 1 0 PrkA AAA domain AAA_11 PF13086.6 EGD96418.1 - 0.072 12.9 0.1 0.072 12.9 0.1 2.2 1 1 1 2 2 2 0 AAA domain AAA_24 PF13479.6 EGD96418.1 - 0.09 12.5 0.1 0.2 11.4 0.1 1.5 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 EGD96418.1 - 0.12 12.1 0.0 0.28 10.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.22 EGD96418.1 - 0.12 11.6 0.0 0.27 10.4 0.0 1.6 1 0 0 1 1 1 0 NB-ARC domain Zeta_toxin PF06414.12 EGD96418.1 - 0.13 11.5 0.1 0.28 10.4 0.1 1.5 1 0 0 1 1 1 0 Zeta toxin AAA_23 PF13476.6 EGD96418.1 - 0.16 12.5 0.1 0.16 12.5 0.1 3.2 1 1 1 2 2 1 0 AAA domain ABC_tran PF00005.27 EGD96418.1 - 0.28 11.7 0.1 0.28 11.7 0.1 2.7 1 1 0 2 2 2 0 ABC transporter Laps PF10169.9 EGD96418.1 - 1.4 9.5 3.9 5.5 7.6 0.1 2.5 1 1 1 2 2 2 0 Learning-associated protein Ribosomal_L23 PF00276.20 EGD96419.1 - 5.2e-10 39.5 0.0 8.8e-10 38.8 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L23 RIO1 PF01163.22 EGD96420.1 - 1.1e-40 139.3 0.3 4.8e-28 98.1 0.0 2.3 2 0 0 2 2 2 2 RIO1 family Rio2_N PF09202.11 EGD96420.1 - 5.5e-32 109.8 0.0 1.3e-31 108.6 0.0 1.6 1 0 0 1 1 1 1 Rio2, N-terminal APH PF01636.23 EGD96420.1 - 1.7e-05 24.9 0.0 0.068 13.1 0.0 2.6 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 EGD96420.1 - 3.7e-05 23.2 0.0 0.0016 17.9 0.0 2.3 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family SGT1 PF07093.11 EGD96420.1 - 0.17 10.3 4.9 2 6.8 5.4 1.9 2 0 0 2 2 2 0 SGT1 protein Chs7 PF12271.8 EGD96421.1 - 4.3e-124 413.5 15.5 5e-124 413.3 15.5 1.0 1 0 0 1 1 1 1 Chitin synthase export chaperone DUF3382 PF11862.8 EGD96421.1 - 9.4 6.6 9.5 2.1 8.7 3.8 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF3382) Ribosomal_L27A PF00828.19 EGD96422.1 - 2.8e-30 105.6 0.4 4.9e-30 104.8 0.4 1.4 1 0 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A Pkinase PF00069.25 EGD96424.1 - 2.8e-46 158.1 0.0 3.9e-46 157.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD96424.1 - 1.6e-26 93.2 0.0 4.6e-21 75.3 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase_fungal PF17667.1 EGD96424.1 - 0.0033 16.3 0.0 0.0061 15.4 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase SelP_N PF04592.14 EGD96424.1 - 0.31 10.4 19.1 0.52 9.7 19.1 1.3 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Zip PF02535.22 EGD96424.1 - 0.46 9.7 3.1 0.68 9.1 3.1 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter NicO PF03824.16 EGD96424.1 - 9.6 5.4 9.1 17 4.6 9.1 1.3 1 0 0 1 1 1 0 High-affinity nickel-transport protein Nucleo_P87 PF07267.11 EGD96425.1 - 0.27 10.1 14.3 0.29 9.9 14.3 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 CRT10 PF08728.10 EGD96425.1 - 1.1 7.3 6.0 1.2 7.2 6.0 1.0 1 0 0 1 1 1 0 CRT10 SH3_1 PF00018.28 EGD96426.1 - 1.8e-05 24.2 0.0 3.6e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EGD96426.1 - 0.0066 16.3 0.0 0.016 15.1 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_16 PF18348.1 EGD96426.1 - 0.033 14.0 0.1 0.1 12.4 0.0 1.8 2 0 0 2 2 2 0 Bacterial dipeptidyl-peptidase Sh3 domain RCC1_2 PF13540.6 EGD96427.1 - 9.6e-15 53.9 7.5 4.8e-08 32.6 0.0 4.8 5 0 0 5 5 5 2 Regulator of chromosome condensation (RCC1) repeat F-box-like PF12937.7 EGD96427.1 - 2.6e-08 33.6 0.5 8.2e-08 32.0 0.1 2.0 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 EGD96427.1 - 0.036 14.0 0.1 0.16 11.9 0.1 2.0 2 0 0 2 2 2 0 F-box domain RCC1 PF00415.18 EGD96427.1 - 0.11 13.2 1.0 4.6 7.9 0.0 3.8 4 1 0 4 4 4 0 Regulator of chromosome condensation (RCC1) repeat PQ-loop PF04193.14 EGD96429.1 - 4.9e-37 125.5 12.0 2.5e-18 65.6 1.7 2.7 2 0 0 2 2 2 2 PQ loop repeat MtN3_slv PF03083.16 EGD96429.1 - 0.001 19.0 6.5 0.016 15.2 0.2 2.9 3 0 0 3 3 3 2 Sugar efflux transporter for intercellular exchange 7TM_GPCR_Srsx PF10320.9 EGD96429.1 - 0.013 14.9 1.2 0.023 14.1 1.2 1.4 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srsx DUF2627 PF11118.8 EGD96429.1 - 0.12 12.9 0.3 4.1 8.0 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2627) Aminotran_1_2 PF00155.21 EGD96430.1 - 1.4e-63 215.3 0.0 2e-63 214.8 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Tmemb_18A PF09771.9 EGD96430.1 - 0.0024 18.3 0.0 0.0044 17.4 0.0 1.4 1 0 0 1 1 1 1 Transmembrane protein 188 Beta_elim_lyase PF01212.21 EGD96430.1 - 0.0048 16.2 0.0 0.0077 15.5 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase AMP-binding PF00501.28 EGD96432.1 - 2.2e-36 125.4 0.0 4e-36 124.5 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme ACAS_N PF16177.5 EGD96432.1 - 2e-09 37.2 1.4 7.5e-09 35.4 0.2 2.2 2 0 0 2 2 2 1 Acetyl-coenzyme A synthetase N-terminus Peptidase_M16_C PF05193.21 EGD96433.1 - 1.2e-48 165.6 0.0 2.7e-48 164.4 0.0 1.6 1 0 0 1 1 1 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 EGD96433.1 - 3.3e-40 137.5 0.0 4.3e-39 133.9 0.0 2.1 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) TRPM_tetra PF16519.5 EGD96433.1 - 0.18 11.9 1.0 0.57 10.3 1.0 1.8 1 0 0 1 1 1 0 Tetramerisation domain of TRPM Abhydrolase_2 PF02230.16 EGD96434.1 - 2.2e-26 93.1 0.0 1.3e-17 64.3 0.0 2.4 2 1 0 2 2 2 2 Phospholipase/Carboxylesterase Hydrolase_4 PF12146.8 EGD96434.1 - 0.0006 19.2 0.0 0.0095 15.2 0.0 2.3 1 1 0 2 2 2 1 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 EGD96434.1 - 0.00098 18.6 0.0 0.0017 17.9 0.0 1.4 1 1 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_6 PF12697.7 EGD96434.1 - 0.039 14.5 0.4 0.063 13.9 0.4 1.4 1 1 0 1 1 1 0 Alpha/beta hydrolase family Abhydrolase_3 PF07859.13 EGD96434.1 - 0.075 12.9 0.0 0.11 12.3 0.0 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold Tom22 PF04281.13 EGD96435.1 - 9.9e-52 174.4 1.1 1.1e-51 174.2 1.1 1.0 1 0 0 1 1 1 1 Mitochondrial import receptor subunit Tom22 DUF4211 PF13926.6 EGD96436.1 - 1.9e-43 148.0 0.0 4e-43 146.9 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4211) SAPS PF04499.15 EGD96436.1 - 5.5 5.7 7.6 1.4 7.6 1.4 2.1 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein DUF4449 PF14613.6 EGD96437.1 - 7.6e-64 214.7 0.7 7.6e-64 214.7 0.7 2.7 3 0 0 3 3 3 1 Protein of unknown function (DUF4449) Peptidase_M35 PF02102.15 EGD96438.1 - 6e-72 242.5 0.0 7.3e-72 242.2 0.0 1.0 1 0 0 1 1 1 1 Deuterolysin metalloprotease (M35) family Aspzincin_M35 PF14521.6 EGD96438.1 - 3.9e-33 115.0 0.2 6.8e-33 114.3 0.2 1.4 1 0 0 1 1 1 1 Lysine-specific metallo-endopeptidase vWA-TerF-like PF10138.9 EGD96440.1 - 5.7e-07 29.8 0.0 8.7e-07 29.2 0.0 1.2 1 0 0 1 1 1 1 vWA found in TerF C terminus Pro-rich PF15240.6 EGD96440.1 - 0.015 15.6 30.5 0.015 15.6 30.5 3.3 2 1 1 3 3 3 0 Proline-rich VWA PF00092.28 EGD96440.1 - 0.092 13.0 0.1 0.19 12.0 0.1 1.5 1 1 0 1 1 1 0 von Willebrand factor type A domain PhoLip_ATPase_C PF16212.5 EGD96441.1 - 4.3e-69 233.0 21.3 4.3e-69 233.0 21.3 2.2 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EGD96441.1 - 6.7e-25 86.6 3.6 1.2e-23 82.6 0.3 2.6 2 0 0 2 2 2 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.26 EGD96441.1 - 1.5e-16 61.3 0.2 3e-06 27.7 0.0 3.4 2 1 1 3 3 3 3 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EGD96441.1 - 2.3e-12 46.8 0.0 1.3e-11 44.4 0.0 2.2 2 0 0 2 2 2 1 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.20 EGD96441.1 - 2.3e-11 43.6 0.2 1.1e-10 41.4 0.1 2.2 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase_3 PF08282.12 EGD96441.1 - 0.0028 17.4 0.0 0.0094 15.7 0.0 1.8 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Homeodomain PF00046.29 EGD96443.1 - 3.9e-20 71.4 2.5 8.2e-20 70.4 2.5 1.6 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EGD96443.1 - 0.0016 18.3 0.4 0.004 17.0 0.4 1.7 1 0 0 1 1 1 1 Homeobox KN domain HNF-1_N PF04814.13 EGD96443.1 - 8.3 7.0 11.6 1.6 9.3 6.5 2.2 2 0 0 2 2 2 0 Hepatocyte nuclear factor 1 (HNF-1), N terminus PGP_phosphatase PF09419.10 EGD96444.1 - 5.8e-52 175.7 0.0 6.7e-52 175.5 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial PGP phosphatase Hydrolase_like PF13242.6 EGD96444.1 - 3.9e-06 26.8 0.1 6.9e-06 26.0 0.1 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.26 EGD96444.1 - 0.00084 19.7 0.2 0.62 10.3 0.0 2.2 1 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase TPP_enzyme_M PF00205.22 EGD96444.1 - 0.028 14.2 0.0 0.063 13.0 0.0 1.6 1 1 1 2 2 2 0 Thiamine pyrophosphate enzyme, central domain LSM PF01423.22 EGD96445.1 - 3.9e-15 55.3 0.2 5.2e-15 54.9 0.2 1.2 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EGD96445.1 - 0.097 12.8 0.1 0.17 12.0 0.1 1.4 1 1 0 1 1 1 0 Ataxin 2 SM domain Adaptin_binding PF10199.9 EGD96446.1 - 4.8e-18 65.9 4.5 4.8e-18 65.9 4.5 1.9 2 0 0 2 2 2 1 Alpha and gamma adaptin binding protein p34 PTPLA PF04387.14 EGD96447.1 - 1.8e-41 141.6 2.2 1.1e-30 106.5 0.0 2.4 1 1 1 2 2 2 2 Protein tyrosine phosphatase-like protein, PTPLA SRP_TPR_like PF17004.5 EGD96448.1 - 8e-19 67.8 0.4 2.4e-18 66.2 0.1 2.0 3 0 0 3 3 3 1 Putative TPR-like repeat SRP72 PF08492.12 EGD96448.1 - 4.6e-14 52.6 6.8 4.6e-14 52.6 6.8 2.0 2 0 0 2 2 2 1 SRP72 RNA-binding domain TPR_19 PF14559.6 EGD96448.1 - 1.6e-08 34.9 2.3 0.0031 18.0 0.0 5.0 3 2 1 4 4 4 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EGD96448.1 - 0.001 19.2 4.4 18 5.6 0.0 6.0 5 2 0 6 6 6 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_20 PF14561.6 EGD96448.1 - 0.0017 18.6 0.5 3 8.2 0.1 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_9 PF13371.6 EGD96448.1 - 0.018 15.2 0.7 0.2 11.8 0.0 3.1 4 0 0 4 4 3 0 Tetratricopeptide repeat AF0941-like PF14591.6 EGD96448.1 - 0.024 15.2 0.6 0.19 12.3 0.1 2.4 2 0 0 2 2 2 0 AF0941-like HrpB1_HrpK PF09613.10 EGD96448.1 - 0.027 14.1 0.1 0.92 9.2 0.0 2.8 3 0 0 3 3 3 0 Bacterial type III secretion protein (HrpB1_HrpK) TPR_2 PF07719.17 EGD96448.1 - 0.047 13.8 7.6 21 5.5 1.0 4.9 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_1 PF00515.28 EGD96448.1 - 0.6 10.0 2.1 1.5e+02 2.5 0.1 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat VCX_VCY PF15231.6 EGD96448.1 - 0.85 10.3 7.7 1.8 9.3 7.7 1.5 1 0 0 1 1 1 0 Variable charge X/Y family Homeobox_KN PF05920.11 EGD96449.1 - 3.5e-20 71.6 0.8 7e-20 70.7 0.8 1.5 1 0 0 1 1 1 1 Homeobox KN domain Homeodomain PF00046.29 EGD96449.1 - 0.00013 21.8 0.2 0.00023 21.0 0.2 1.4 1 0 0 1 1 1 1 Homeodomain FAD_binding_1 PF00667.20 EGD96450.1 - 9.1e-45 152.9 0.0 1.2e-44 152.5 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain NAD_binding_1 PF00175.21 EGD96450.1 - 3.7e-09 37.2 0.0 1.1e-08 35.7 0.0 1.8 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain Med20 PF08612.11 EGD96453.1 - 1e-57 195.1 0.0 1.3e-57 194.8 0.0 1.1 1 0 0 1 1 1 1 TATA-binding related factor (TRF) of subunit 20 of Mediator complex EF-hand_1 PF00036.32 EGD96454.1 - 1.3e-41 137.0 11.6 7.8e-10 37.6 0.9 4.1 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 EGD96454.1 - 3.6e-36 123.4 5.3 3.9e-19 68.9 2.2 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 EGD96454.1 - 1.9e-34 117.3 11.5 2.4e-15 56.1 0.6 4.0 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.6 EGD96454.1 - 3.8e-30 101.2 8.5 7.1e-09 34.9 0.1 4.4 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 EGD96454.1 - 6.8e-26 88.6 9.8 4.7e-06 25.9 0.1 4.2 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.6 EGD96454.1 - 1.4e-16 60.5 0.4 2.3e-09 37.4 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 EGD96454.1 - 6.8e-10 38.8 1.6 0.00078 19.4 0.3 2.1 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 EGD96454.1 - 5.9e-09 36.2 0.2 0.0016 18.7 0.1 2.1 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region UPF0154 PF03672.13 EGD96454.1 - 1e-06 28.6 0.1 0.008 16.2 0.0 3.0 2 1 1 3 3 3 2 Uncharacterised protein family (UPF0154) EFhand_Ca_insen PF08726.10 EGD96454.1 - 6.4e-06 26.2 1.6 2.3e-05 24.4 0.2 2.3 2 1 0 2 2 2 1 Ca2+ insensitive EF hand EF-hand_11 PF08976.11 EGD96454.1 - 9.4e-05 23.2 0.2 0.0025 18.6 0.1 2.0 1 1 1 2 2 2 1 EF-hand domain TerB PF05099.13 EGD96454.1 - 0.00013 21.9 0.3 0.35 10.8 0.0 2.2 1 1 1 2 2 2 2 Tellurite resistance protein TerB Caleosin PF05042.13 EGD96454.1 - 0.00059 19.8 1.6 0.52 10.2 0.0 3.5 1 1 3 4 4 4 1 Caleosin related protein RNA_pol_Rpb4 PF03874.16 EGD96454.1 - 0.00062 20.1 0.7 0.66 10.3 0.1 2.6 2 1 1 3 3 3 2 RNA polymerase Rpb4 Dockerin_1 PF00404.18 EGD96454.1 - 0.0053 16.9 7.0 0.38 11.0 0.8 2.9 1 1 2 3 3 3 2 Dockerin type I domain DUF5580 PF17743.1 EGD96454.1 - 0.0057 15.3 0.0 0.0058 15.2 0.0 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5580) SurA_N_2 PF13623.6 EGD96454.1 - 0.0084 16.0 0.7 0.32 10.9 0.1 2.2 1 1 1 2 2 2 1 SurA N-terminal domain EF-hand_14 PF17959.1 EGD96454.1 - 0.012 16.0 0.5 6.2 7.2 0.1 2.4 1 1 1 2 2 2 0 EF-hand domain Poly_export PF02563.16 EGD96454.1 - 0.023 14.9 0.0 0.18 12.0 0.0 2.5 2 1 0 2 2 2 0 Polysaccharide biosynthesis/export protein RuvA_C PF07499.13 EGD96454.1 - 0.058 13.9 0.1 8.5 6.9 0.0 3.0 3 0 0 3 3 3 0 RuvA, C-terminal domain dCache_2 PF08269.11 EGD96454.1 - 0.061 12.5 0.1 1 8.5 0.1 2.1 1 1 1 2 2 2 0 Cache domain MotA_activ PF09114.10 EGD96454.1 - 0.061 13.5 0.3 0.91 9.7 0.0 2.3 1 1 0 2 2 2 0 Transcription factor MotA, activation domain DUF4497 PF14924.6 EGD96454.1 - 0.092 13.2 0.0 8.7 6.9 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4497) RloB PF13707.6 EGD96454.1 - 0.11 12.7 1.3 0.72 10.0 0.2 2.1 1 1 1 2 2 2 0 RloB-like protein DUF5132 PF17195.4 EGD96454.1 - 0.16 12.1 0.5 21 5.3 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF5132) SNARE PF05739.19 EGD96455.1 - 7.2e-15 54.7 1.6 1.7e-14 53.6 1.6 1.7 1 0 0 1 1 1 1 SNARE domain Syntaxin PF00804.25 EGD96455.1 - 0.0014 18.3 8.8 0.0027 17.4 8.8 1.5 1 1 0 1 1 1 1 Syntaxin MCPsignal PF00015.21 EGD96455.1 - 0.11 12.3 6.5 0.07 12.9 0.8 2.5 3 0 0 3 3 3 0 Methyl-accepting chemotaxis protein (MCP) signalling domain CTD_bind PF04818.13 EGD96456.1 - 1.9e-17 63.8 0.1 1.1e-16 61.4 0.0 2.2 2 0 0 2 2 2 1 RNA polymerase II-binding domain. YscO-like PF16789.5 EGD96456.1 - 0.057 13.5 1.0 0.14 12.2 1.0 1.6 1 0 0 1 1 1 0 YscO-like protein Spc7 PF08317.11 EGD96456.1 - 0.07 12.0 1.2 0.19 10.6 0.3 2.0 2 0 0 2 2 2 0 Spc7 kinetochore protein CTK3 PF12243.8 EGD96456.1 - 0.11 12.5 0.0 0.34 10.9 0.0 1.8 1 0 0 1 1 1 0 CTD kinase subunit gamma CTK3 MCD_N PF17408.2 EGD96456.1 - 0.13 12.4 0.4 6.6 6.9 0.0 3.5 4 0 0 4 4 4 0 Malonyl-CoA decarboxylase N-terminal domain YjcZ PF13990.6 EGD96456.1 - 0.21 10.9 3.0 8.9 5.6 0.4 2.3 2 0 0 2 2 2 0 YjcZ-like protein POTRA_TamA_1 PF17243.2 EGD96456.1 - 0.32 11.1 1.7 15 5.8 0.7 3.4 3 0 0 3 3 3 0 POTRA domain TamA domain 1 Clathrin_lg_ch PF01086.17 EGD96457.1 - 2.2e-74 250.4 2.9 2.5e-74 250.2 2.9 1.0 1 0 0 1 1 1 1 Clathrin light chain Acyl_transf_3 PF01757.22 EGD96458.1 - 1.8e-15 56.8 21.0 2.3e-15 56.5 21.0 1.1 1 0 0 1 1 1 1 Acyltransferase family Mannosyl_trans3 PF11051.8 EGD96460.1 - 7.9e-56 189.4 0.0 6.2e-32 111.0 0.0 2.2 1 1 1 2 2 2 2 Mannosyltransferase putative CDC37_N PF03234.14 EGD96461.1 - 1.5e-50 171.4 2.1 1.5e-50 171.4 2.1 3.0 3 1 0 3 3 3 1 Cdc37 N terminal kinase binding CDC37_M PF08565.11 EGD96461.1 - 8.7e-41 138.5 0.4 2.6e-40 137.0 0.1 2.0 2 0 0 2 2 2 1 Cdc37 Hsp90 binding domain CDC37_C PF08564.10 EGD96461.1 - 1.2e-35 121.6 3.8 1.2e-35 121.6 3.8 2.3 3 0 0 3 3 3 1 Cdc37 C terminal domain MecA_N PF05223.11 EGD96461.1 - 0.0039 17.4 2.7 0.0055 17.0 1.0 2.2 2 0 0 2 2 2 1 NTF2-like N-terminal transpeptidase domain DUF3573 PF12097.8 EGD96461.1 - 0.047 12.5 0.5 0.074 11.9 0.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) Thiamine_BP PF01910.17 EGD96461.1 - 0.068 13.1 0.4 0.28 11.1 0.0 2.1 2 0 0 2 2 2 0 Thiamine-binding protein DUF2680 PF10925.8 EGD96461.1 - 0.85 9.7 4.6 5.5 7.1 0.3 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2680) ABC_membrane PF00664.23 EGD96462.1 - 2.4e-48 165.2 11.5 3.2e-48 164.8 11.5 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 EGD96462.1 - 3.1e-35 121.7 0.0 9.3e-35 120.1 0.0 1.9 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 EGD96462.1 - 6.4e-07 29.0 0.1 5.1e-05 22.8 0.0 2.3 1 1 1 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 EGD96462.1 - 0.00022 21.6 0.9 0.00079 19.9 0.1 2.3 2 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 EGD96462.1 - 0.0025 18.1 0.1 0.02 15.2 0.1 2.3 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.6 EGD96462.1 - 0.0057 16.4 0.5 0.018 14.8 0.0 2.1 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA PF00004.29 EGD96462.1 - 0.014 15.8 0.0 0.075 13.5 0.0 2.2 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) IstB_IS21 PF01695.17 EGD96462.1 - 0.03 14.1 0.2 0.5 10.1 0.0 2.5 2 1 1 3 3 3 0 IstB-like ATP binding protein AAA_30 PF13604.6 EGD96462.1 - 0.042 13.6 0.0 0.14 11.9 0.0 1.9 1 1 0 1 1 1 0 AAA domain AAA_25 PF13481.6 EGD96462.1 - 0.045 13.3 0.1 0.47 10.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain Sigma54_activ_2 PF14532.6 EGD96462.1 - 0.06 13.5 0.0 0.59 10.2 0.0 2.4 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_15 PF13175.6 EGD96462.1 - 0.11 12.2 0.0 0.17 11.6 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain AAA_5 PF07728.14 EGD96462.1 - 0.12 12.4 0.1 0.88 9.6 0.0 2.2 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 EGD96462.1 - 0.14 12.7 0.3 1.2 9.7 0.1 2.3 2 0 0 2 2 2 0 AAA domain SbcCD_C PF13558.6 EGD96462.1 - 0.22 11.8 1.4 2.5 8.4 0.6 3.0 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit Nucleoside_tran PF01733.18 EGD96463.1 - 1.1e-38 133.4 14.3 1.6e-37 129.6 11.9 2.9 1 1 1 2 2 2 1 Nucleoside transporter MFS_1 PF07690.16 EGD96463.1 - 5.9e-06 25.4 34.8 0.00011 21.3 10.2 2.8 1 1 0 2 2 2 2 Major Facilitator Superfamily Ac76 PF05814.11 EGD96463.1 - 0.9 9.6 2.9 1.8 8.7 0.3 2.6 2 0 0 2 2 2 0 Orf76 (Ac76) DUF5090 PF17009.5 EGD96463.1 - 2.7 7.9 7.9 40 4.1 0.1 3.7 4 0 0 4 4 4 0 Domain of unknown function (DUF5090) Gate PF07670.14 EGD96463.1 - 3.7 7.9 9.9 0.65 10.3 4.2 2.6 2 0 0 2 2 2 0 Nucleoside recognition Metallophos_2 PF12850.7 EGD96466.1 - 5.9e-08 33.1 0.0 2.1e-06 28.0 0.0 2.2 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.28 EGD96466.1 - 6.7e-08 33.3 0.1 1e-07 32.7 0.1 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Haspin_kinase PF12330.8 EGD96467.1 - 8e-44 150.1 0.0 1.1e-43 149.6 0.0 1.3 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 EGD96467.1 - 0.028 14.3 0.0 0.053 13.4 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF1682 PF07946.14 EGD96469.1 - 3.7e-114 381.3 2.1 4.2e-114 381.1 2.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1682) DUF3619 PF12279.8 EGD96469.1 - 0.012 15.9 0.8 8.6 6.7 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3619) Thymidylate_kin PF02223.17 EGD96469.1 - 0.017 14.8 1.3 0.029 14.0 1.3 1.4 1 0 0 1 1 1 0 Thymidylate kinase COX7a PF02238.15 EGD96470.1 - 9e-23 80.4 2.3 1.1e-22 80.1 2.3 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VII PPR_3 PF13812.6 EGD96471.1 - 0.011 15.8 0.0 0.025 14.6 0.0 1.5 1 0 0 1 1 1 0 Pentatricopeptide repeat domain SYF2 PF08231.12 EGD96473.1 - 4.3e-56 189.7 17.8 4.3e-56 189.7 17.8 2.2 2 0 0 2 2 2 1 SYF2 splicing factor ARD PF03079.14 EGD96473.1 - 0.081 13.1 0.5 0.081 13.1 0.5 3.5 2 1 2 4 4 4 0 ARD/ARD' family POT1PC PF16686.5 EGD96473.1 - 0.47 10.3 7.1 0.28 11.0 0.4 2.8 3 0 0 3 3 3 0 ssDNA-binding domain of telomere protection protein DUF1797 PF08796.10 EGD96473.1 - 1.1 9.4 4.3 0.58 10.3 0.3 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF1797) Ndc1_Nup PF09531.10 EGD96473.1 - 2.2 6.9 7.7 2.5 6.7 7.7 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup NAD_binding_10 PF13460.6 EGD96474.1 - 3.1e-07 30.5 0.0 1.2e-06 28.6 0.0 1.9 1 1 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EGD96474.1 - 2.9e-06 26.9 0.0 7.2e-06 25.6 0.0 1.6 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EGD96474.1 - 3.6e-05 22.9 0.0 0.00014 20.9 0.0 1.8 1 1 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family adh_short PF00106.25 EGD96474.1 - 0.0025 17.3 0.0 0.004 16.6 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase NAD_binding_4 PF07993.12 EGD96474.1 - 0.009 15.2 0.1 0.77 8.9 0.1 3.1 2 1 0 2 2 2 1 Male sterility protein GDP_Man_Dehyd PF16363.5 EGD96474.1 - 0.0094 15.4 0.0 0.015 14.8 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 EGD96474.1 - 0.011 14.8 0.0 0.029 13.5 0.0 1.7 2 0 0 2 2 2 0 RmlD substrate binding domain Pox_RNA_Pol_19 PF05320.12 EGD96474.1 - 0.033 14.2 0.0 0.048 13.6 0.0 1.3 1 0 0 1 1 1 0 Poxvirus DNA-directed RNA polymerase 19 kDa subunit KR PF08659.10 EGD96474.1 - 0.04 13.8 0.0 0.14 12.1 0.0 1.9 2 0 0 2 2 2 0 KR domain SMRP1 PF15181.6 EGD96474.1 - 0.044 13.4 0.0 0.061 12.9 0.0 1.1 1 0 0 1 1 1 0 Spermatid-specific manchette-related protein 1 NmrA PF05368.13 EGD96474.1 - 0.055 13.0 0.0 0.1 12.1 0.0 1.5 1 0 0 1 1 1 0 NmrA-like family Polysacc_synt_2 PF02719.15 EGD96474.1 - 0.094 11.8 0.0 0.37 9.9 0.0 1.8 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein YEATS PF03366.16 EGD96475.1 - 1.2e-36 124.5 0.7 1.9e-36 123.9 0.7 1.3 1 0 0 1 1 1 1 YEATS family YebG PF07130.12 EGD96475.1 - 0.11 12.4 0.2 0.38 10.6 0.1 1.8 2 0 0 2 2 2 0 YebG protein Rep_fac_C PF08542.11 EGD96476.1 - 2.6e-24 85.4 0.1 9.5e-24 83.6 0.0 2.0 2 0 0 2 2 2 1 Replication factor C C-terminal domain DNA_pol3_delta2 PF13177.6 EGD96476.1 - 6e-12 45.6 0.0 1e-08 35.1 0.0 2.2 1 1 1 2 2 2 2 DNA polymerase III, delta subunit AAA PF00004.29 EGD96476.1 - 3.2e-11 43.8 0.0 5.4e-11 43.0 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 EGD96476.1 - 1.1e-06 28.8 0.0 2.2e-06 27.7 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EGD96476.1 - 3.2e-06 27.6 0.0 0.00017 22.0 0.0 2.3 1 1 1 2 2 2 1 AAA ATPase domain Viral_helicase1 PF01443.18 EGD96476.1 - 2.7e-05 24.0 0.0 4.3e-05 23.4 0.0 1.3 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase RuvB_N PF05496.12 EGD96476.1 - 5.3e-05 23.0 0.0 0.00012 21.8 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EGD96476.1 - 0.00011 22.5 0.1 0.14 12.4 0.1 2.4 1 1 1 2 2 2 2 AAA domain AAA_3 PF07726.11 EGD96476.1 - 0.00023 21.0 0.0 0.00043 20.2 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta PF06144.13 EGD96476.1 - 0.00058 19.7 0.0 0.00094 19.0 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase III, delta subunit Mg_chelatase PF01078.21 EGD96476.1 - 0.0023 17.4 0.0 0.023 14.1 0.0 2.1 1 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_assoc_2 PF16193.5 EGD96476.1 - 0.0054 17.0 0.0 0.015 15.6 0.0 1.9 1 0 0 1 1 1 1 AAA C-terminal domain AAA_24 PF13479.6 EGD96476.1 - 0.0067 16.2 0.0 0.03 14.0 0.0 1.9 2 0 0 2 2 2 1 AAA domain MeaB PF03308.16 EGD96476.1 - 0.0068 15.4 0.0 0.012 14.6 0.0 1.4 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB Rad17 PF03215.15 EGD96476.1 - 0.0071 16.3 0.0 0.014 15.3 0.0 1.4 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_19 PF13245.6 EGD96476.1 - 0.016 15.5 0.1 0.042 14.2 0.1 1.8 1 1 0 1 1 1 0 AAA domain DEAD PF00270.29 EGD96476.1 - 0.018 14.8 0.1 0.92 9.3 0.0 2.4 1 1 1 2 2 2 0 DEAD/DEAH box helicase AAA_11 PF13086.6 EGD96476.1 - 0.019 14.8 0.0 0.031 14.1 0.0 1.3 1 1 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 EGD96476.1 - 0.024 14.6 0.2 0.08 12.9 0.1 1.9 1 1 1 2 2 2 0 NTPase TniB PF05621.11 EGD96476.1 - 0.029 13.8 0.0 3.8 6.9 0.0 2.3 2 0 0 2 2 2 0 Bacterial TniB protein KTI12 PF08433.10 EGD96476.1 - 0.061 12.8 0.0 0.1 12.0 0.0 1.5 1 1 0 1 1 1 0 Chromatin associated protein KTI12 AAA_30 PF13604.6 EGD96476.1 - 0.11 12.2 0.1 0.37 10.5 0.1 1.8 1 1 0 1 1 1 0 AAA domain His_Phos_2 PF00328.22 EGD96477.1 - 1.6e-05 24.4 0.0 0.0032 16.9 0.0 2.6 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) DUF1338 PF07063.13 EGD96478.1 - 7.2e-95 317.9 0.0 3.8e-47 161.1 0.0 2.0 1 1 1 2 2 2 2 Domain of unknown function (DUF1338) DUF410 PF04190.13 EGD96480.1 - 1.5e-88 296.9 0.0 1.7e-88 296.7 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF410) RAI1 PF08652.11 EGD96481.1 - 4.6e-27 94.0 0.1 1.1e-26 92.7 0.0 1.7 2 0 0 2 2 2 1 RAI1 like PD-(D/E)XK nuclease IPPT PF01715.17 EGD96482.1 - 7.1e-62 209.2 0.1 1.2e-61 208.5 0.1 1.3 1 0 0 1 1 1 1 IPP transferase IPT PF01745.16 EGD96482.1 - 5.4e-05 22.7 0.1 0.00017 21.1 0.0 1.8 2 0 0 2 2 2 1 Isopentenyl transferase AAA_33 PF13671.6 EGD96482.1 - 7.1e-05 23.0 0.7 0.004 17.3 0.3 3.0 2 1 0 2 2 2 1 AAA domain AAA_18 PF13238.6 EGD96482.1 - 0.0036 17.8 1.9 1.2 9.7 0.0 3.2 2 1 1 3 3 3 1 AAA domain zf-met PF12874.7 EGD96482.1 - 0.0048 17.2 0.0 0.0086 16.4 0.0 1.4 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 EGD96482.1 - 0.0061 16.9 0.4 0.021 15.2 0.0 2.0 2 0 0 2 2 2 1 C2H2 type zinc-finger (2 copies) AAA_25 PF13481.6 EGD96482.1 - 0.0092 15.6 0.4 0.048 13.2 0.1 2.1 2 0 0 2 2 2 1 AAA domain zf-C2H2_jaz PF12171.8 EGD96482.1 - 0.013 15.7 0.0 0.026 14.8 0.0 1.5 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding PhoH PF02562.16 EGD96482.1 - 0.11 11.9 0.1 0.24 10.8 0.1 1.5 1 0 0 1 1 1 0 PhoH-like protein DUF87 PF01935.17 EGD96482.1 - 1.1 9.3 6.4 1.1 9.3 0.1 2.9 2 1 1 3 3 3 0 Helicase HerA, central domain DUF3811 PF11656.8 EGD96482.1 - 3.1 8.3 7.2 4.5 7.7 0.1 2.9 3 0 0 3 3 3 0 YjbD family (DUF3811) ABC_tran PF00005.27 EGD96483.1 - 3.2e-05 24.5 0.0 0.00012 22.6 0.0 1.9 1 1 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 EGD96483.1 - 0.00092 19.1 0.2 0.0014 18.5 0.2 1.2 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EGD96483.1 - 0.11 12.0 0.0 0.11 12.0 0.0 1.1 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain WD40 PF00400.32 EGD96484.1 - 9.9e-32 108.5 26.5 4.8e-05 24.0 0.0 11.8 12 0 0 12 12 12 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EGD96484.1 - 3.5e-06 27.2 0.4 45 4.5 0.0 6.7 6 2 0 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain DUF4596 PF15363.6 EGD96484.1 - 0.17 12.1 1.3 0.48 10.7 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4596) Urm1 PF09138.11 EGD96485.1 - 1.1e-34 118.6 0.0 1.3e-34 118.4 0.0 1.0 1 0 0 1 1 1 1 Urm1 (Ubiquitin related modifier) ThiS PF02597.20 EGD96485.1 - 0.038 14.6 0.0 0.048 14.3 0.0 1.3 1 0 0 1 1 1 0 ThiS family 6PF2K PF01591.18 EGD96486.1 - 6.1e-62 208.8 0.0 9.4e-62 208.2 0.0 1.3 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 EGD96486.1 - 1.3e-19 70.7 0.0 6.1e-19 68.5 0.0 1.9 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.6 EGD96486.1 - 0.088 13.0 0.0 0.37 10.9 0.0 2.0 2 0 0 2 2 2 0 AAA domain Porin_3 PF01459.22 EGD96487.1 - 6.1e-81 271.8 0.0 7.1e-81 271.6 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic porin Zds_C PF08632.10 EGD96487.1 - 0.017 14.9 0.0 0.037 13.8 0.0 1.5 1 0 0 1 1 1 0 Activator of mitotic machinery Cdc14 phosphatase activation C-term UPF0564 PF10595.9 EGD96489.1 - 0.003 16.7 1.8 0.0038 16.3 1.8 1.2 1 0 0 1 1 1 1 Uncharacterised protein family UPF0564 Pkinase PF00069.25 EGD96490.1 - 2.8e-64 217.0 0.0 3.4e-64 216.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD96490.1 - 7.5e-24 84.4 0.0 1e-23 84.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EGD96490.1 - 3e-06 26.8 0.0 9.3e-06 25.2 0.0 1.7 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 EGD96490.1 - 0.00071 19.6 0.3 0.021 14.7 0.0 2.7 2 1 1 3 3 3 1 Phosphotransferase enzyme family MIF4G_like PF09088.11 EGD96491.1 - 4e-88 294.2 0.2 7.8e-88 293.2 0.2 1.5 1 0 0 1 1 1 1 MIF4G like MIF4G_like_2 PF09090.11 EGD96491.1 - 2.4e-72 243.6 0.0 3.9e-72 242.9 0.0 1.3 1 0 0 1 1 1 1 MIF4G like TonB_dep_Rec PF00593.24 EGD96491.1 - 0.35 10.7 0.5 0.54 10.1 0.5 1.1 1 0 0 1 1 1 0 TonB dependent receptor WD40 PF00400.32 EGD96493.1 - 2.5e-58 192.6 15.8 4.2e-09 36.9 0.7 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat Tup_N PF08581.10 EGD96493.1 - 1.3e-18 67.1 9.3 2.1e-18 66.4 9.3 1.4 1 0 0 1 1 1 1 Tup N-terminal ANAPC4_WD40 PF12894.7 EGD96493.1 - 1.3e-15 57.4 0.0 0.0059 16.9 0.0 6.7 2 2 5 7 7 7 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EGD96493.1 - 9.6e-08 31.7 0.0 0.064 12.6 0.0 4.2 2 1 2 4 4 4 3 WD40-like domain Cytochrom_D1 PF02239.16 EGD96493.1 - 1.2e-05 24.0 0.5 0.00015 20.4 0.2 2.4 1 1 1 2 2 2 2 Cytochrome D1 heme domain Ge1_WD40 PF16529.5 EGD96493.1 - 2.1e-05 23.7 0.2 0.78 8.6 0.0 4.6 1 1 1 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 EGD96493.1 - 6.5e-05 21.8 0.1 0.25 9.9 0.0 3.1 2 1 1 3 3 3 2 Nucleoporin Nup120/160 eIF2A PF08662.11 EGD96493.1 - 0.0011 18.9 0.0 0.071 13.0 0.0 2.6 1 1 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A MMS1_N PF10433.9 EGD96493.1 - 0.013 14.2 0.0 2.4 6.7 0.0 2.2 2 0 0 2 2 2 0 Mono-functional DNA-alkylating methyl methanesulfonate N-term Nbas_N PF15492.6 EGD96493.1 - 0.02 14.2 0.0 6.6 6.0 0.0 2.7 2 1 1 3 3 3 0 Neuroblastoma-amplified sequence, N terminal PD40 PF07676.12 EGD96493.1 - 0.022 14.7 0.0 20 5.3 0.0 4.0 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat TPX2 PF06886.11 EGD96493.1 - 5.1 7.4 6.7 11 6.4 6.7 1.5 1 1 0 1 1 1 0 Targeting protein for Xklp2 (TPX2) zf-C2H2 PF00096.26 EGD96495.1 - 3e-18 65.2 23.3 6.7e-05 23.1 0.9 4.5 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EGD96495.1 - 5.8e-16 58.1 21.9 8.3e-08 32.3 2.2 4.9 5 0 0 5 5 5 4 Zinc-finger double domain zf-C2H2_4 PF13894.6 EGD96495.1 - 4.1e-11 42.7 19.3 0.024 15.5 0.6 4.4 4 0 0 4 4 4 4 C2H2-type zinc finger zf-C2H2_aberr PF17017.5 EGD96495.1 - 1.6e-05 25.2 1.7 0.028 14.6 0.1 3.0 2 1 1 3 3 3 2 Aberrant zinc-finger zf-met PF12874.7 EGD96495.1 - 0.00016 22.0 7.0 0.15 12.5 0.2 4.1 4 0 0 4 4 4 2 Zinc-finger of C2H2 type zf-C2H2_8 PF15909.5 EGD96495.1 - 0.00047 20.4 5.9 0.0032 17.7 2.1 2.9 1 1 2 3 3 3 1 C2H2-type zinc ribbon FOXP-CC PF16159.5 EGD96495.1 - 0.01 16.4 4.5 19 6.0 0.1 3.4 2 1 1 3 3 3 0 FOXP coiled-coil domain zf-LYAR PF08790.11 EGD96495.1 - 0.032 14.1 10.2 4.5 7.3 0.4 4.6 4 0 0 4 4 4 0 LYAR-type C2HC zinc finger C1_4 PF07975.12 EGD96495.1 - 0.086 13.1 2.1 0.6 10.4 0.6 2.6 2 0 0 2 2 2 0 TFIIH C1-like domain zf-C2H2_6 PF13912.6 EGD96495.1 - 0.12 12.5 0.5 0.12 12.5 0.5 4.0 4 0 0 4 4 3 0 C2H2-type zinc finger CHORD PF04968.12 EGD96495.1 - 6.2 7.6 12.2 5.6 7.8 1.9 3.9 3 1 1 4 4 4 0 CHORD Mito_carr PF00153.27 EGD96496.1 - 2.4e-68 226.1 5.3 6.9e-23 80.4 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Tom7 PF08038.12 EGD96497.1 - 3.2e-14 52.3 0.4 3.9e-14 52.0 0.4 1.1 1 0 0 1 1 1 1 TOM7 family RRM_1 PF00076.22 EGD96498.1 - 6.4e-27 93.2 0.2 1.4e-15 56.9 0.0 3.1 2 1 1 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EGD96498.1 - 0.0013 18.3 0.0 0.031 13.9 0.0 2.2 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 EGD96498.1 - 0.0096 16.0 0.2 0.78 9.8 0.1 2.2 2 0 0 2 2 2 1 Limkain b1 Cas_Cas2CT1978 PF09707.10 EGD96498.1 - 0.023 14.8 0.0 1.9 8.6 0.0 2.3 2 0 0 2 2 2 0 CRISPR-associated protein (Cas_Cas2CT1978) PHM7_cyt PF14703.6 EGD96498.1 - 0.044 14.0 0.0 1.1 9.4 0.0 2.3 2 0 0 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter CMV_1a_C PF12503.8 EGD96498.1 - 0.07 13.1 0.1 16 5.6 0.0 2.3 2 0 0 2 2 2 0 Cucumber mosaic virus 1a protein C terminal OB_RNB PF08206.11 EGD96498.1 - 0.1 12.3 0.1 6.9 6.4 0.0 2.4 2 0 0 2 2 2 0 Ribonuclease B OB domain RRM_occluded PF16842.5 EGD96498.1 - 0.17 11.8 0.0 0.33 10.8 0.0 1.4 1 0 0 1 1 1 0 Occluded RNA-recognition motif DUF2015 PF09435.10 EGD96499.1 - 1.8e-43 147.0 0.0 2e-43 146.8 0.0 1.0 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF2015) Ribosomal_L28e PF01778.17 EGD96500.1 - 1.1e-31 110.0 0.1 1.4e-31 109.6 0.1 1.1 1 0 0 1 1 1 1 Ribosomal L28e protein family Ldh_1_N PF00056.23 EGD96501.1 - 1.4e-44 151.6 0.0 2.2e-44 151.0 0.0 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.18 EGD96501.1 - 2.7e-42 144.5 0.0 3.7e-42 144.1 0.0 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain 3Beta_HSD PF01073.19 EGD96501.1 - 0.00076 18.6 0.0 0.001 18.2 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Glyco_hydro_4 PF02056.16 EGD96501.1 - 0.15 11.6 0.0 0.26 10.8 0.0 1.5 1 0 0 1 1 1 0 Family 4 glycosyl hydrolase TRAPP PF04051.16 EGD96502.1 - 1.4e-43 148.1 0.0 1.8e-43 147.8 0.0 1.1 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component Glyco_transf_90 PF05686.12 EGD96503.1 - 6e-18 64.9 7.2 2.4e-13 49.8 4.7 3.7 2 1 0 2 2 2 2 Glycosyl transferase family 90 PINIT PF14324.6 EGD96504.1 - 5e-40 137.2 0.0 8.6e-40 136.4 0.0 1.4 1 0 0 1 1 1 1 PINIT domain zf-MIZ PF02891.20 EGD96504.1 - 3e-22 78.1 6.5 6.1e-22 77.1 6.5 1.5 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger SAP PF02037.27 EGD96504.1 - 1.8e-06 27.6 0.3 4.8e-06 26.2 0.3 1.7 1 0 0 1 1 1 1 SAP domain zf-Nse PF11789.8 EGD96504.1 - 5.8e-06 26.0 2.1 1.2e-05 25.0 2.1 1.6 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-Sec23_Sec24 PF04810.15 EGD96504.1 - 0.058 13.5 0.7 0.16 12.1 0.7 1.8 1 1 0 1 1 1 0 Sec23/Sec24 zinc finger zf-C3HC4_2 PF13923.6 EGD96504.1 - 2.4 8.1 6.0 5.4 6.9 6.0 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DUF2423 PF10338.9 EGD96505.1 - 1.6e-20 73.0 0.5 1.6e-20 73.0 0.5 2.1 3 0 0 3 3 3 1 Protein of unknown function (DUF2423) Phosphodiest PF01663.22 EGD96506.1 - 2.2e-14 53.9 1.1 4.6e-08 33.1 0.1 2.2 1 1 0 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 EGD96506.1 - 0.03 13.7 0.0 0.34 10.3 0.0 2.1 2 0 0 2 2 2 0 Sulfatase DUF2567 PF10821.8 EGD96506.1 - 0.29 11.2 5.2 6.7 6.8 1.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF2567) Caveolin PF01146.17 EGD96507.1 - 0.025 14.5 0.0 0.049 13.6 0.0 1.5 1 0 0 1 1 1 0 Caveolin Red1 PF07964.11 EGD96507.1 - 0.031 12.5 4.2 0.037 12.3 4.2 1.1 1 0 0 1 1 1 0 Rec10 / Red1 MARCKS PF02063.17 EGD96507.1 - 0.41 10.6 8.6 0.075 13.0 0.8 2.0 2 0 0 2 2 2 0 MARCKS family VIGSSK PF14773.6 EGD96507.1 - 0.57 10.3 2.8 21 5.3 0.1 2.8 2 1 1 3 3 3 0 Helicase-associated putative binding domain, C-terminal Amidohydro_1 PF01979.20 EGD96510.1 - 9.7e-10 38.3 0.3 2.1e-09 37.2 0.3 1.4 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_2 PF04909.14 EGD96510.1 - 5.1e-08 33.1 0.0 8.9e-08 32.3 0.0 1.4 1 0 0 1 1 1 1 Amidohydrolase CoA_binding_2 PF13380.6 EGD96510.1 - 0.0024 18.3 0.2 0.032 14.7 0.1 2.5 2 1 1 3 3 3 1 CoA binding domain DnaJ-X PF14308.6 EGD96511.1 - 1.6e-79 266.3 5.8 1.6e-79 266.3 5.8 2.9 3 1 0 3 3 3 1 X-domain of DnaJ-containing DnaJ PF00226.31 EGD96511.1 - 4.1e-25 87.7 0.3 1e-24 86.4 0.3 1.8 1 0 0 1 1 1 1 DnaJ domain Condensin2nSMC PF12422.8 EGD96511.1 - 0.036 14.2 0.2 0.11 12.6 0.1 2.0 2 0 0 2 2 2 0 Condensin II non structural maintenance of chromosomes subunit OrfB_IS605 PF01385.19 EGD96511.1 - 0.25 11.6 2.2 0.65 10.2 2.2 1.7 1 0 0 1 1 1 0 Probable transposase IMS PF00817.20 EGD96513.1 - 4.7e-42 143.5 0.8 1.1e-41 142.4 0.3 1.9 2 0 0 2 2 2 1 impB/mucB/samB family IMS_C PF11799.8 EGD96513.1 - 1.1e-13 51.9 0.2 2.9e-13 50.6 0.2 1.6 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain IMS_HHH PF11798.8 EGD96513.1 - 3.5e-05 23.9 0.0 0.0001 22.4 0.0 1.9 1 0 0 1 1 1 1 IMS family HHH motif NIBRIN_BRCT_II PF16508.5 EGD96514.1 - 1.8e-29 102.5 0.0 3.5e-29 101.5 0.0 1.5 1 0 0 1 1 1 1 Second BRCT domain on Nijmegen syndrome breakage protein FHA PF00498.26 EGD96514.1 - 1.4e-05 25.3 0.3 2.7e-05 24.4 0.3 1.5 1 0 0 1 1 1 1 FHA domain Acetyltransf_1 PF00583.25 EGD96515.1 - 2.9e-08 34.0 0.7 3.6e-08 33.6 0.1 1.5 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EGD96515.1 - 9.5e-08 32.0 0.0 2.4e-07 30.7 0.0 1.8 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EGD96515.1 - 8.3e-06 26.1 0.3 2e-05 24.9 0.0 1.8 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EGD96515.1 - 0.17 11.9 0.0 0.84 9.7 0.0 2.2 2 1 0 2 2 2 0 FR47-like protein Ferritin_2 PF13668.6 EGD96516.1 - 1.3e-12 48.1 0.1 2.3e-12 47.3 0.1 1.3 1 0 0 1 1 1 1 Ferritin-like domain Retinal PF15449.6 EGD96516.1 - 9.4 3.9 10.9 16 3.1 10.9 1.3 1 0 0 1 1 1 0 Retinal protein Sugar_tr PF00083.24 EGD96517.1 - 1.5e-21 76.8 19.9 1.2e-11 44.2 4.2 2.2 2 0 0 2 2 2 2 Sugar (and other) transporter Pkinase PF00069.25 EGD96519.1 - 1.3e-29 103.4 0.0 9.2e-29 100.6 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD96519.1 - 5.3e-11 42.3 0.0 6.1e-07 29.0 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase AMP-binding PF00501.28 EGD96520.1 - 1.4e-76 257.8 0.0 1.7e-76 257.5 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EGD96520.1 - 9.5e-12 45.7 0.7 2.2e-11 44.5 0.7 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain MFS_1 PF07690.16 EGD96521.1 - 1.8e-39 135.7 25.7 1.8e-39 135.7 25.7 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily CoA_binding_2 PF13380.6 EGD96523.1 - 1.4e-27 96.5 0.0 1.6e-27 96.3 0.0 1.1 1 0 0 1 1 1 1 CoA binding domain Methyltransf_11 PF08241.12 EGD96525.1 - 8.3e-23 80.9 0.0 1.4e-22 80.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EGD96525.1 - 1.1e-20 74.1 0.0 2.4e-20 73.1 0.0 1.6 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EGD96525.1 - 8.8e-12 45.1 0.0 1.3e-11 44.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EGD96525.1 - 9.5e-11 42.3 0.0 2.4e-10 41.0 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 EGD96525.1 - 1.4e-10 41.2 0.0 2.2e-10 40.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EGD96525.1 - 5.4e-09 35.7 0.0 4.8e-08 32.6 0.0 2.0 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family MTS PF05175.14 EGD96525.1 - 0.00038 20.0 0.0 0.00065 19.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_18 PF12847.7 EGD96525.1 - 0.0022 17.9 0.0 0.0034 17.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 EGD96525.1 - 0.0035 16.7 0.0 0.0076 15.6 0.0 1.5 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase DREV PF05219.12 EGD96525.1 - 0.0042 16.2 0.0 0.0068 15.5 0.0 1.2 1 0 0 1 1 1 1 DREV methyltransferase PrmA PF06325.13 EGD96525.1 - 0.021 14.2 0.0 0.034 13.6 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) MetW PF07021.12 EGD96525.1 - 0.11 12.1 0.0 0.17 11.5 0.0 1.2 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW Methyltransf_8 PF05148.15 EGD96525.1 - 0.12 12.2 0.0 0.35 10.7 0.0 1.7 1 1 0 1 1 1 0 Hypothetical methyltransferase Methyltransf_32 PF13679.6 EGD96525.1 - 0.14 12.2 0.0 0.21 11.5 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain HIT PF01230.23 EGD96526.1 - 7.8e-23 81.1 0.3 1.3e-22 80.3 0.0 1.5 2 0 0 2 2 2 1 HIT domain DcpS_C PF11969.8 EGD96526.1 - 1.1e-05 25.9 0.0 2.1e-05 25.0 0.0 1.4 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding CwfJ_C_1 PF04677.15 EGD96526.1 - 0.01 15.7 0.0 0.018 14.9 0.0 1.3 1 0 0 1 1 1 0 Protein similar to CwfJ C-terminus 1 GalP_UDP_tr_C PF02744.17 EGD96526.1 - 0.088 12.5 0.0 0.14 11.8 0.0 1.3 1 0 0 1 1 1 0 Galactose-1-phosphate uridyl transferase, C-terminal domain Rad4 PF03835.15 EGD96527.1 - 3.3e-31 107.9 1.6 5.4e-31 107.3 0.0 2.2 2 0 0 2 2 2 1 Rad4 transglutaminase-like domain BHD_3 PF10405.9 EGD96527.1 - 8.7e-29 99.8 0.2 1.8e-28 98.7 0.2 1.6 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 3 BHD_2 PF10404.9 EGD96527.1 - 1.3e-16 61.3 1.6 3.1e-16 60.1 0.1 2.5 2 0 0 2 2 2 1 Rad4 beta-hairpin domain 2 BHD_1 PF10403.9 EGD96527.1 - 1.8e-14 53.3 0.3 6e-14 51.6 0.1 2.1 2 0 0 2 2 2 1 Rad4 beta-hairpin domain 1 Transglut_core PF01841.19 EGD96527.1 - 0.0021 18.5 0.0 0.01 16.3 0.0 2.2 1 0 0 1 1 1 1 Transglutaminase-like superfamily DNA_pol_phi PF04931.13 EGD96527.1 - 5.3 5.0 6.9 8.5 4.3 6.9 1.2 1 0 0 1 1 1 0 DNA polymerase phi HD_3 PF13023.6 EGD96528.1 - 9.9e-49 165.4 0.1 1.2e-48 165.2 0.1 1.1 1 0 0 1 1 1 1 HD domain HD_2 PF12917.7 EGD96528.1 - 4.5e-13 49.3 0.1 6.4e-13 48.9 0.1 1.2 1 0 0 1 1 1 1 HD containing hydrolase-like enzyme HD PF01966.22 EGD96528.1 - 0.016 15.4 0.0 0.04 14.1 0.0 1.7 1 1 0 1 1 1 0 HD domain HATPase_c_4 PF13749.6 EGD96528.1 - 0.13 12.4 0.0 0.3 11.3 0.0 1.7 1 0 0 1 1 1 0 Putative ATP-dependent DNA helicase recG C-terminal HAUS6_N PF14661.6 EGD96529.1 - 6.1e-43 147.0 0.1 6.1e-43 147.0 0.1 1.6 2 0 0 2 2 2 1 HAUS augmin-like complex subunit 6 N-terminus cobW PF02492.19 EGD96530.1 - 2.4e-48 164.1 0.4 4e-48 163.3 0.4 1.4 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.14 EGD96530.1 - 6.6e-07 29.2 0.0 1.2e-06 28.3 0.0 1.5 1 0 0 1 1 1 1 Cobalamin synthesis protein cobW C-terminal domain RsgA_GTPase PF03193.16 EGD96530.1 - 7.4e-05 22.7 0.1 0.26 11.2 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase ATP_bind_1 PF03029.17 EGD96530.1 - 0.00078 19.3 0.1 0.0029 17.4 0.0 2.0 2 1 0 2 2 2 1 Conserved hypothetical ATP binding protein AAA_30 PF13604.6 EGD96530.1 - 0.0018 18.0 0.0 0.94 9.2 0.0 2.9 3 0 0 3 3 3 1 AAA domain AAA_18 PF13238.6 EGD96530.1 - 0.0024 18.4 0.0 0.04 14.4 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EGD96530.1 - 0.0062 16.9 0.0 0.018 15.4 0.0 1.7 2 0 0 2 2 2 1 AAA ATPase domain MMR_HSR1 PF01926.23 EGD96530.1 - 0.0068 16.5 0.0 0.017 15.2 0.0 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase TsaE PF02367.17 EGD96530.1 - 0.0084 16.1 0.0 0.28 11.2 0.0 2.6 2 1 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE ATPase_2 PF01637.18 EGD96530.1 - 0.013 15.4 0.0 0.028 14.3 0.0 1.5 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea T2SSE PF00437.20 EGD96530.1 - 0.02 14.0 0.0 0.037 13.1 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_22 PF13401.6 EGD96530.1 - 0.047 14.0 0.0 0.12 12.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain Auxin_BP PF02041.16 EGD96530.1 - 0.047 13.4 0.0 0.084 12.5 0.0 1.4 1 0 0 1 1 1 0 Auxin binding protein CDCA PF18484.1 EGD96530.1 - 0.05 13.5 0.0 0.081 12.8 0.0 1.3 1 0 0 1 1 1 0 Cadmium carbonic anhydrase repeat AAA_23 PF13476.6 EGD96530.1 - 0.073 13.6 0.1 0.19 12.2 0.1 1.6 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 EGD96530.1 - 0.08 13.5 0.0 0.2 12.1 0.0 1.7 1 0 0 1 1 1 0 ABC transporter Zeta_toxin PF06414.12 EGD96530.1 - 0.084 12.1 0.0 0.21 10.8 0.0 1.6 2 0 0 2 2 2 0 Zeta toxin Viral_helicase1 PF01443.18 EGD96530.1 - 0.11 12.3 0.0 0.32 10.7 0.0 1.8 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase AAA_14 PF13173.6 EGD96530.1 - 0.12 12.4 0.1 0.4 10.7 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 EGD96530.1 - 0.17 11.7 0.1 1.1 9.1 0.0 2.3 3 0 0 3 3 2 0 P-loop containing region of AAA domain Mob1_phocein PF03637.17 EGD96531.1 - 1.1e-23 84.1 0.2 5e-23 82.0 0.0 1.8 2 0 0 2 2 2 1 Mob1/phocein family CxC6 PF18721.1 EGD96531.1 - 0.39 11.0 5.1 0.73 10.1 5.1 1.4 1 0 0 1 1 1 0 CxC6 like cysteine cluster associated with KDZ transposases Pkinase PF00069.25 EGD96532.1 - 6.3e-11 42.1 0.0 1.9e-09 37.3 0.0 2.4 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD96532.1 - 1.4e-09 37.6 0.0 1.7e-08 34.1 0.0 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase DUF1158 PF06643.11 EGD96534.1 - 0.095 13.2 0.0 0.29 11.7 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1158) Lon_C PF05362.13 EGD96535.1 - 1.3e-63 214.3 0.0 2.7e-63 213.2 0.0 1.5 1 0 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain AAA PF00004.29 EGD96535.1 - 4.5e-22 78.9 0.0 1.2e-21 77.5 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) LON_substr_bdg PF02190.16 EGD96535.1 - 7.4e-13 48.8 0.3 2.1e-12 47.4 0.3 1.7 1 0 0 1 1 1 1 ATP-dependent protease La (LON) substrate-binding domain AAA_5 PF07728.14 EGD96535.1 - 4.8e-07 29.8 0.0 1e-06 28.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) ChlI PF13541.6 EGD96535.1 - 2.4e-06 27.4 0.0 7.1e-06 25.9 0.0 1.9 1 0 0 1 1 1 1 Subunit ChlI of Mg-chelatase AAA_2 PF07724.14 EGD96535.1 - 3.4e-06 27.3 0.0 9e-06 25.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 EGD96535.1 - 1.6e-05 25.2 0.0 0.0002 21.6 0.0 2.5 1 1 0 1 1 1 1 AAA domain AAA_PrkA PF08298.11 EGD96535.1 - 2.1e-05 23.6 0.1 5.9e-05 22.1 0.0 1.7 2 0 0 2 2 2 1 PrkA AAA domain RuvB_N PF05496.12 EGD96535.1 - 3.1e-05 23.8 0.5 0.00056 19.7 0.0 3.1 4 0 0 4 4 4 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EGD96535.1 - 0.00028 21.3 1.6 0.0019 18.6 0.0 2.8 2 1 1 3 3 3 1 AAA ATPase domain AAA_18 PF13238.6 EGD96535.1 - 0.0057 17.2 1.1 0.056 14.0 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_14 PF13173.6 EGD96535.1 - 0.024 14.7 0.0 0.055 13.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 EGD96535.1 - 0.03 14.1 0.0 0.061 13.0 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_30 PF13604.6 EGD96535.1 - 0.031 14.0 0.0 0.083 12.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 EGD96535.1 - 0.031 14.2 0.2 0.1 12.5 0.0 1.9 2 0 0 2 2 1 0 RsgA GTPase AAA_7 PF12775.7 EGD96535.1 - 0.066 12.7 0.5 0.14 11.7 0.0 1.7 2 0 0 2 2 2 0 P-loop containing dynein motor region RNA_helicase PF00910.22 EGD96535.1 - 0.07 13.5 0.0 0.17 12.3 0.0 1.7 1 0 0 1 1 1 0 RNA helicase F-box-like_2 PF13013.6 EGD96535.1 - 0.083 12.9 0.0 0.22 11.5 0.0 1.7 1 0 0 1 1 1 0 F-box-like domain NTPase_1 PF03266.15 EGD96535.1 - 0.085 12.8 0.2 1.2 9.1 0.0 2.5 1 1 1 2 2 2 0 NTPase Phage_connect_1 PF05135.13 EGD96535.1 - 0.11 13.1 0.6 7.4 7.1 0.0 3.4 3 0 0 3 3 3 0 Phage gp6-like head-tail connector protein SKI PF01202.22 EGD96535.1 - 0.33 11.1 0.0 0.33 11.1 0.0 2.4 3 0 0 3 3 2 0 Shikimate kinase DUF2161 PF09929.9 EGD96535.1 - 0.37 10.9 1.5 5.3 7.2 0.1 3.0 2 1 1 3 3 3 0 Putative PD-(D/E)XK phosphodiesterase (DUF2161) DUF445 PF04286.12 EGD96535.1 - 0.4 10.5 6.3 0.28 10.9 2.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF445) ABC_tran PF00005.27 EGD96535.1 - 0.71 10.4 4.8 0.71 10.4 0.1 2.9 3 0 0 3 3 3 0 ABC transporter APH PF01636.23 EGD96537.1 - 4.5e-12 46.4 0.0 7.9e-12 45.6 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EGD96537.1 - 0.0052 16.4 0.0 0.0088 15.7 0.0 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase DnaJ_C PF01556.18 EGD96538.1 - 1.1e-36 126.1 0.0 1.6e-36 125.7 0.0 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 EGD96538.1 - 1.7e-23 82.5 0.8 5.1e-23 81.0 0.4 2.0 2 0 0 2 2 2 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 EGD96538.1 - 1.1e-09 38.5 21.4 1.1e-09 38.5 21.4 1.9 2 0 0 2 2 2 1 DnaJ central domain HypA PF01155.19 EGD96538.1 - 0.26 11.3 8.7 0.081 12.9 1.1 2.3 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Anti-TRAP PF15777.5 EGD96538.1 - 2.8 8.0 19.7 0.19 11.7 5.2 2.9 1 1 1 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein BRO1 PF03097.18 EGD96539.1 - 1.1e-129 432.7 0.5 1.1e-129 432.7 0.5 1.9 2 1 0 2 2 2 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.6 EGD96539.1 - 7.3e-81 271.7 15.4 1.4e-80 270.8 15.4 1.5 1 0 0 1 1 1 1 ALIX V-shaped domain binding to HIV DUF2383 PF09537.10 EGD96539.1 - 0.69 10.3 7.2 1.3 9.4 0.5 4.4 5 0 0 5 5 5 0 Domain of unknown function (DUF2383) DUF416 PF04222.12 EGD96539.1 - 3.1 7.2 6.9 1.2 8.5 0.1 3.2 4 1 1 5 5 5 0 Protein of unknown function (DUF416) SAP30_Sin3_bdg PF13867.6 EGD96540.1 - 2.3e-09 37.4 0.2 7e-09 35.9 0.1 1.9 2 0 0 2 2 2 1 Sin3 binding region of histone deacetylase complex subunit SAP30 F-box PF00646.33 EGD96541.1 - 2e-05 24.3 0.0 6.2e-05 22.8 0.0 1.9 1 0 0 1 1 1 1 F-box domain F-box_4 PF15966.5 EGD96541.1 - 0.0028 17.5 0.1 0.0062 16.4 0.1 1.6 1 0 0 1 1 1 1 F-box F-box-like PF12937.7 EGD96541.1 - 0.003 17.4 0.0 0.0079 16.1 0.0 1.8 1 0 0 1 1 1 1 F-box-like PRANC PF09372.10 EGD96541.1 - 0.13 12.7 0.6 0.29 11.5 0.1 1.9 2 0 0 2 2 2 0 PRANC domain zf-H2C2_2 PF13465.6 EGD96542.1 - 8.1e-06 26.0 23.1 4.5e-05 23.7 2.0 4.0 3 1 0 3 3 3 2 Zinc-finger double domain Dicty_REP PF05086.12 EGD96542.1 - 0.0018 16.4 4.4 0.0022 16.1 4.4 1.1 1 0 0 1 1 1 1 Dictyostelium (Slime Mold) REP protein FSA_C PF10479.9 EGD96542.1 - 0.96 7.5 12.9 1.8 6.6 12.9 1.4 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus MOSC PF03473.17 EGD96543.1 - 7.8e-19 68.0 0.0 1.2e-18 67.4 0.0 1.2 1 0 0 1 1 1 1 MOSC domain MOSC_N PF03476.16 EGD96543.1 - 1.1e-08 35.0 0.0 5.8e-08 32.6 0.0 2.0 2 0 0 2 2 2 1 MOSC N-terminal beta barrel domain Amidase PF01425.21 EGD96544.1 - 1e-68 232.4 0.0 1.2e-67 228.8 0.0 2.0 1 1 0 1 1 1 1 Amidase Rad51 PF08423.11 EGD96545.1 - 7.9e-12 45.0 0.0 4.4e-11 42.5 0.0 2.1 2 1 0 2 2 2 1 Rad51 ATPase PF06745.13 EGD96545.1 - 1.4e-05 24.6 0.2 0.00011 21.7 0.0 2.2 2 1 0 2 2 2 1 KaiC RecA PF00154.21 EGD96545.1 - 3.7e-05 23.3 0.0 0.00012 21.6 0.0 1.8 2 0 0 2 2 2 1 recA bacterial DNA recombination protein PhoH PF02562.16 EGD96545.1 - 0.00038 20.0 0.0 0.00063 19.2 0.0 1.3 1 0 0 1 1 1 1 PhoH-like protein AAA_25 PF13481.6 EGD96545.1 - 0.00094 18.8 0.9 0.0046 16.6 0.1 2.6 3 1 0 3 3 3 1 AAA domain IstB_IS21 PF01695.17 EGD96545.1 - 0.0025 17.5 0.0 0.0044 16.8 0.0 1.3 1 0 0 1 1 1 1 IstB-like ATP binding protein CbiA PF01656.23 EGD96545.1 - 0.004 17.2 0.0 0.02 14.9 0.0 2.0 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_16 PF13191.6 EGD96545.1 - 0.0077 16.6 1.0 0.018 15.4 0.0 2.1 2 1 0 2 2 2 1 AAA ATPase domain ATPase_2 PF01637.18 EGD96545.1 - 0.0095 15.9 0.1 0.019 14.9 0.0 1.6 2 0 0 2 2 2 1 ATPase domain predominantly from Archaea ABC_tran PF00005.27 EGD96545.1 - 0.019 15.5 0.5 0.05 14.1 0.0 1.8 2 0 0 2 2 2 0 ABC transporter RNA12 PF10443.9 EGD96545.1 - 0.037 12.8 1.3 0.079 11.7 0.0 1.9 2 0 0 2 2 2 0 RNA12 protein Zot PF05707.12 EGD96545.1 - 0.064 12.9 0.0 0.099 12.3 0.0 1.2 1 0 0 1 1 1 0 Zonular occludens toxin (Zot) DnaB_C PF03796.15 EGD96545.1 - 0.13 11.6 0.0 1.7 7.9 0.0 2.1 2 0 0 2 2 2 0 DnaB-like helicase C terminal domain RRN3 PF05327.11 EGD96545.1 - 1.6 7.2 4.9 2.5 6.6 4.9 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 FA_desaturase PF00487.24 EGD96547.1 - 5.8e-18 65.6 14.1 1.1e-17 64.7 14.1 1.4 1 0 0 1 1 1 1 Fatty acid desaturase Cyt-b5 PF00173.28 EGD96547.1 - 2.3e-17 62.9 0.2 5.7e-17 61.6 0.0 1.8 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain DUF1189 PF06691.11 EGD96547.1 - 0.015 14.9 0.1 0.028 14.0 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1189) Eaf7 PF07904.13 EGD96547.1 - 2.5 8.5 4.5 3.6 8.0 0.2 2.2 2 0 0 2 2 2 0 Chromatin modification-related protein EAF7 Peptidase_M3 PF01432.20 EGD96548.1 - 2.4e-165 551.3 0.4 3.2e-165 550.8 0.4 1.2 1 0 0 1 1 1 1 Peptidase family M3 DUF4637 PF15470.6 EGD96549.1 - 0.051 13.3 3.4 0.12 12.1 3.4 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) YABBY PF04690.13 EGD96549.1 - 0.1 13.2 0.8 11 6.5 0.4 2.5 2 1 0 2 2 2 0 YABBY protein CDC45 PF02724.14 EGD96549.1 - 0.2 9.9 3.5 0.26 9.5 3.5 1.1 1 0 0 1 1 1 0 CDC45-like protein CobT PF06213.12 EGD96549.1 - 0.31 10.4 8.8 0.5 9.7 8.8 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT PI3K_1B_p101 PF10486.9 EGD96549.1 - 0.4 8.4 4.6 0.59 7.8 4.6 1.2 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit RNA_pol_Rpc4 PF05132.14 EGD96549.1 - 1.7 9.1 5.5 0.2 12.1 0.7 1.9 2 0 0 2 2 2 0 RNA polymerase III RPC4 Nucleo_P87 PF07267.11 EGD96549.1 - 2.8 6.7 4.9 3.5 6.4 4.9 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 Paf1 PF03985.13 EGD96549.1 - 5 6.0 10.8 6.9 5.6 10.8 1.1 1 0 0 1 1 1 0 Paf1 EF-hand_7 PF13499.6 EGD96550.1 - 3.6e-13 49.8 0.2 9.1e-09 35.7 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_9 PF14658.6 EGD96550.1 - 4.8e-11 42.8 0.0 3.7e-05 23.9 0.0 2.4 2 1 0 2 2 2 2 EF-hand domain EF-hand_6 PF13405.6 EGD96550.1 - 4.3e-10 38.7 0.1 0.01 15.7 0.0 3.5 3 0 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.32 EGD96550.1 - 1.2e-09 37.0 0.0 0.017 14.6 0.0 3.7 3 1 0 3 3 3 3 EF hand EF-hand_8 PF13833.6 EGD96550.1 - 1e-06 28.4 0.1 3.7e-05 23.5 0.0 2.9 2 1 1 3 3 3 1 EF-hand domain pair DUF3216 PF11505.8 EGD96550.1 - 0.093 12.9 0.0 0.15 12.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3216) EF-hand_14 PF17959.1 EGD96550.1 - 0.097 13.0 0.0 11 6.5 0.0 2.2 2 0 0 2 2 2 0 EF-hand domain Fungal_trans PF04082.18 EGD96552.1 - 3.3e-63 213.2 1.2 5.5e-63 212.5 0.6 1.7 2 0 0 2 2 2 1 Fungal specific transcription factor domain zf-C2H2 PF00096.26 EGD96552.1 - 0.00036 20.8 14.7 0.0053 17.1 3.8 2.9 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_8 PF15909.5 EGD96552.1 - 0.011 16.0 1.5 0.036 14.3 1.5 1.9 1 0 0 1 1 1 0 C2H2-type zinc ribbon zf-C2H2_4 PF13894.6 EGD96552.1 - 6.5 7.9 19.9 0.34 11.9 3.3 3.5 3 0 0 3 3 3 0 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EGD96552.1 - 9.2 6.9 10.4 2 9.0 2.7 2.8 2 0 0 2 2 2 0 Zinc-finger double domain Glyco_transf_90 PF05686.12 EGD96554.1 - 2.6e-13 49.7 0.3 3e-12 46.1 0.2 2.5 2 1 0 2 2 2 1 Glycosyl transferase family 90 DUF3932 PF13068.6 EGD96554.1 - 0.078 13.3 0.0 0.64 10.3 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3932) Xpo1 PF08389.12 EGD96555.1 - 7.8e-29 100.7 0.1 1.6e-27 96.4 0.1 3.0 2 0 0 2 2 2 1 Exportin 1-like protein IBN_N PF03810.19 EGD96555.1 - 7.2e-05 22.6 0.2 0.00023 21.0 0.1 2.0 2 0 0 2 2 2 1 Importin-beta N-terminal domain HEAT_2 PF13646.6 EGD96555.1 - 0.0032 17.8 0.0 0.03 14.7 0.0 2.7 2 0 0 2 2 2 1 HEAT repeats HEAT_EZ PF13513.6 EGD96555.1 - 0.018 15.5 0.0 0.25 11.9 0.0 3.1 2 0 0 2 2 2 0 HEAT-like repeat GAT PF03127.14 EGD96555.1 - 0.037 14.3 0.0 2.6 8.4 0.0 2.9 2 0 0 2 2 2 0 GAT domain HEAT PF02985.22 EGD96555.1 - 0.052 13.8 0.0 24 5.5 0.0 4.2 4 0 0 4 4 4 0 HEAT repeat DUF2267 PF10025.9 EGD96555.1 - 1.7 9.0 4.2 6 7.2 0.3 3.7 4 0 0 4 4 4 0 Uncharacterized conserved protein (DUF2267) LSM PF01423.22 EGD96556.1 - 2.8e-13 49.3 0.2 3.4e-13 49.1 0.2 1.1 1 0 0 1 1 1 1 LSM domain Hfq PF17209.3 EGD96556.1 - 0.001 18.7 0.1 0.0016 18.0 0.1 1.3 1 0 0 1 1 1 1 Hfq protein 5-FTHF_cyc-lig PF01812.20 EGD96557.1 - 2.8e-33 115.3 0.0 6.8e-33 114.1 0.0 1.5 1 1 0 1 1 1 1 5-formyltetrahydrofolate cyclo-ligase family Rot1 PF10681.9 EGD96558.1 - 1.7e-92 308.7 0.0 1.9e-92 308.5 0.0 1.0 1 0 0 1 1 1 1 Chaperone for protein-folding within the ER, fungal YqeY PF09424.10 EGD96559.1 - 3.2e-21 75.9 6.1 3.9e-21 75.6 6.1 1.1 1 0 0 1 1 1 1 Yqey-like protein Ino80_Iec3 PF14612.6 EGD96559.1 - 0.075 13.7 0.4 0.096 13.3 0.4 1.2 1 0 0 1 1 1 0 IEC3 subunit of the Ino80 complex, chromatin re-modelling Nucleoporin_N PF08801.11 EGD96560.1 - 4.9e-88 295.8 0.2 7.3e-88 295.2 0.2 1.3 1 0 0 1 1 1 1 Nup133 N terminal like Nucleoporin_C PF03177.14 EGD96560.1 - 2.3e-37 129.0 0.0 6e-30 104.6 0.0 2.9 2 1 1 3 3 3 2 Non-repetitive/WGA-negative nucleoporin C-terminal Fungal_lectin PF07938.12 EGD96560.1 - 0.16 11.3 0.0 0.41 10.0 0.0 1.6 2 0 0 2 2 2 0 Fungal fucose-specific lectin DUF2781 PF10914.8 EGD96561.1 - 1.9e-40 138.7 11.7 2.1e-40 138.5 11.7 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2781) SLAC1 PF03595.17 EGD96561.1 - 0.0047 16.2 3.1 0.0055 16.0 3.1 1.0 1 0 0 1 1 1 1 Voltage-dependent anion channel NAT PF04768.13 EGD96562.1 - 4.2e-51 173.0 0.0 9.1e-51 171.9 0.0 1.5 1 0 0 1 1 1 1 NAT, N-acetyltransferase, of N-acetylglutamate synthase Pyr_redox_2 PF07992.14 EGD96563.1 - 4.7e-36 124.5 0.0 5.8e-36 124.2 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EGD96563.1 - 2.3e-16 60.1 0.0 2.6e-12 47.1 0.0 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EGD96563.1 - 2.2e-07 30.5 0.0 0.00014 21.2 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EGD96563.1 - 1.7e-06 27.4 0.0 3.3e-05 23.2 0.0 2.1 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 EGD96563.1 - 9.2e-06 25.8 0.0 0.013 15.7 0.0 2.7 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 EGD96563.1 - 4.4e-05 23.5 0.3 0.053 13.5 0.0 3.8 3 1 1 4 4 4 1 FAD-NAD(P)-binding HI0933_like PF03486.14 EGD96563.1 - 0.00063 18.6 0.0 0.17 10.6 0.0 2.4 2 0 0 2 2 2 2 HI0933-like protein Trp_halogenase PF04820.14 EGD96563.1 - 0.00099 18.1 0.0 6.5 5.5 0.0 3.1 3 0 0 3 3 3 2 Tryptophan halogenase Lycopene_cycl PF05834.12 EGD96563.1 - 0.0013 17.8 0.0 1.6 7.7 0.0 2.5 3 0 0 3 3 3 2 Lycopene cyclase protein TrkA_N PF02254.18 EGD96563.1 - 0.0014 18.9 0.0 1.1 9.5 0.0 2.4 2 0 0 2 2 2 2 TrkA-N domain DUF1188 PF06690.11 EGD96563.1 - 0.0034 16.9 0.0 0.016 14.8 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF1188) DAO PF01266.24 EGD96563.1 - 0.0052 16.4 0.1 3.1 7.3 0.1 2.7 2 1 1 3 3 3 2 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 EGD96563.1 - 0.0079 15.5 0.0 0.48 9.6 0.0 2.3 2 1 0 2 2 2 1 FAD binding domain NAD_binding_7 PF13241.6 EGD96563.1 - 0.065 13.7 0.0 2.8 8.4 0.0 2.5 2 0 0 2 2 2 0 Putative NAD(P)-binding TPR_12 PF13424.6 EGD96564.1 - 6.1e-35 119.3 11.0 9.6e-12 45.0 0.9 7.4 2 1 7 9 9 8 7 Tetratricopeptide repeat TPR_10 PF13374.6 EGD96564.1 - 8e-27 92.3 6.0 0.00021 21.1 0.1 8.9 8 0 0 8 8 8 6 Tetratricopeptide repeat Helo_like_N PF17111.5 EGD96564.1 - 5e-09 35.8 0.2 2.3e-08 33.7 0.2 2.1 1 1 0 1 1 1 1 Fungal N-terminal domain of STAND proteins TPR_MalT PF17874.1 EGD96564.1 - 1.7e-07 31.0 1.5 0.052 12.9 0.1 3.4 2 1 2 4 4 4 3 MalT-like TPR region TPR_4 PF07721.14 EGD96564.1 - 1.9e-06 27.9 6.8 0.14 12.9 0.5 5.7 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_19 PF14559.6 EGD96564.1 - 2.2e-06 28.1 7.9 0.72 10.4 0.1 5.6 4 3 2 6 6 6 2 Tetratricopeptide repeat TPR_2 PF07719.17 EGD96564.1 - 2.5e-05 24.1 5.8 16 5.9 0.0 6.7 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_16 PF13432.6 EGD96564.1 - 4.5e-05 24.0 6.3 0.15 12.7 1.2 5.7 5 1 0 5 5 5 1 Tetratricopeptide repeat TPR_1 PF00515.28 EGD96564.1 - 0.00022 20.9 0.6 4.8 7.2 0.0 5.4 6 0 0 6 6 5 1 Tetratricopeptide repeat DUF3427 PF11907.8 EGD96564.1 - 0.0012 18.2 0.2 0.0024 17.2 0.2 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3427) NB-ARC PF00931.22 EGD96564.1 - 0.0013 18.0 0.0 0.0032 16.7 0.0 1.6 1 0 0 1 1 1 1 NB-ARC domain ATPase_2 PF01637.18 EGD96564.1 - 0.0025 17.8 0.1 0.016 15.2 0.0 2.3 2 0 0 2 2 2 1 ATPase domain predominantly from Archaea TPR_14 PF13428.6 EGD96564.1 - 0.0046 17.7 12.3 6 8.0 0.1 7.2 7 0 0 7 7 7 1 Tetratricopeptide repeat NACHT PF05729.12 EGD96564.1 - 0.0063 16.5 0.0 0.032 14.1 0.0 2.2 2 0 0 2 2 2 1 NACHT domain SesA PF17107.5 EGD96564.1 - 0.017 15.3 0.1 0.11 12.7 0.0 2.5 1 1 1 2 2 2 0 N-terminal domain on NACHT_NTPase and P-loop NTPases TPR_7 PF13176.6 EGD96564.1 - 0.019 15.0 6.4 34 4.8 0.1 6.5 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_8 PF13181.6 EGD96564.1 - 0.036 14.3 1.6 19 5.8 0.0 4.8 5 0 0 5 5 4 0 Tetratricopeptide repeat Arf PF00025.21 EGD96564.1 - 0.047 13.2 0.0 0.29 10.6 0.0 2.1 1 1 0 1 1 1 0 ADP-ribosylation factor family FlgN PF05130.12 EGD96564.1 - 0.049 14.2 0.1 0.049 14.2 0.1 2.7 3 0 0 3 3 3 0 FlgN protein AAA_22 PF13401.6 EGD96564.1 - 0.068 13.4 0.0 0.29 11.4 0.0 2.1 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 EGD96564.1 - 0.14 11.8 0.0 0.43 10.3 0.0 1.8 1 0 0 1 1 1 0 AAA domain DUF1664 PF07889.12 EGD96564.1 - 0.49 10.4 6.0 21 5.2 0.0 4.5 4 1 1 5 5 4 0 Protein of unknown function (DUF1664) Arv1 PF04161.13 EGD96565.1 - 2.6e-61 207.4 0.0 7.8e-52 176.5 0.0 2.3 2 0 0 2 2 2 2 Arv1-like family DUF1180 PF06679.12 EGD96565.1 - 3 8.2 5.1 7.3 7.0 5.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) Dabb PF07876.12 EGD96567.1 - 5.5e-16 59.0 0.0 5.9e-16 58.9 0.0 1.0 1 0 0 1 1 1 1 Stress responsive A/B Barrel Domain DUF4123 PF13503.6 EGD96567.1 - 0.16 12.4 0.0 0.18 12.2 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4123) Aminotran_3 PF00202.21 EGD96569.1 - 5.2e-82 275.7 0.0 6.3e-82 275.4 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III BAR_2 PF10455.9 EGD96570.1 - 3.1e-46 157.8 0.7 7.7e-44 149.9 0.7 2.2 1 1 0 1 1 1 1 Bin/amphiphysin/Rvs domain for vesicular trafficking BAR PF03114.18 EGD96570.1 - 2.8e-14 53.3 4.2 1.7e-13 50.8 4.2 1.9 1 1 0 1 1 1 1 BAR domain BAR_3 PF16746.5 EGD96570.1 - 0.012 15.4 0.7 0.076 12.7 0.0 2.1 2 0 0 2 2 2 0 BAR domain of APPL family ApoLp-III PF07464.11 EGD96570.1 - 0.014 15.5 2.2 0.6 10.2 0.1 2.4 2 0 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) TetR_C_24 PF17932.1 EGD96570.1 - 0.057 13.7 0.2 0.19 12.0 0.1 1.9 2 1 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain DUF4972 PF16342.5 EGD96570.1 - 0.11 12.2 0.2 3.1 7.5 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4972) Glyco_hydro_72 PF03198.14 EGD96573.1 - 3.8e-130 433.8 1.0 4.7e-130 433.5 1.0 1.1 1 0 0 1 1 1 1 Glucanosyltransferase X8 PF07983.13 EGD96573.1 - 6.2e-23 81.3 0.5 6.2e-23 81.3 0.5 2.0 2 0 0 2 2 2 1 X8 domain Glyco_hydro_2_C PF02836.17 EGD96573.1 - 0.016 14.3 0.1 0.092 11.8 0.1 2.3 2 1 0 2 2 2 0 Glycosyl hydrolases family 2, TIM barrel domain Cellulase PF00150.18 EGD96573.1 - 0.071 12.5 0.3 12 5.2 0.0 2.4 2 0 0 2 2 2 0 Cellulase (glycosyl hydrolase family 5) NAD_binding_2 PF03446.15 EGD96574.1 - 1.1e-25 90.6 0.1 2.9e-25 89.3 0.0 1.7 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 EGD96574.1 - 3e-11 43.6 0.9 5.1e-11 42.9 0.9 1.4 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase Shikimate_DH PF01488.20 EGD96574.1 - 1.2e-06 28.6 0.2 2.6e-06 27.5 0.1 1.6 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase F420_oxidored PF03807.17 EGD96574.1 - 4.7e-06 27.1 0.3 2.2e-05 24.9 0.1 2.2 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent ADH_zinc_N PF00107.26 EGD96574.1 - 0.0081 16.1 1.0 4.7 7.2 0.0 2.7 2 0 0 2 2 2 2 Zinc-binding dehydrogenase Abhydrolase_6 PF12697.7 EGD96576.1 - 2.9e-14 54.2 0.2 3.7e-14 53.8 0.2 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EGD96576.1 - 6.8e-12 45.6 0.2 2.8e-10 40.3 0.1 2.3 2 1 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EGD96576.1 - 4.8e-11 42.4 0.0 7e-11 41.9 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Thioesterase PF00975.20 EGD96576.1 - 0.0011 19.1 0.0 0.0017 18.6 0.0 1.3 1 0 0 1 1 1 1 Thioesterase domain PGAP1 PF07819.13 EGD96576.1 - 0.002 17.9 0.0 0.0033 17.2 0.0 1.3 1 0 0 1 1 1 1 PGAP1-like protein Peptidase_S28 PF05577.12 EGD96576.1 - 0.027 13.3 0.0 0.039 12.8 0.0 1.1 1 0 0 1 1 1 0 Serine carboxypeptidase S28 YjbR PF04237.13 EGD96578.1 - 0.0035 17.9 0.1 0.045 14.3 0.0 2.1 1 1 1 2 2 2 1 YjbR Thioredoxin PF00085.20 EGD96579.1 - 5.7e-56 186.9 0.0 4.2e-28 97.4 0.0 2.3 2 0 0 2 2 2 2 Thioredoxin ERp29 PF07749.12 EGD96579.1 - 1.1e-20 74.3 1.8 2.4e-20 73.2 1.1 1.9 2 0 0 2 2 2 1 Endoplasmic reticulum protein ERp29, C-terminal domain Thioredoxin_2 PF13098.6 EGD96579.1 - 2.3e-14 53.7 0.0 2.9e-06 27.7 0.0 2.5 2 0 0 2 2 2 2 Thioredoxin-like domain OST3_OST6 PF04756.13 EGD96579.1 - 9.7e-13 48.1 0.0 1.6e-05 24.4 0.0 2.2 1 1 1 2 2 2 2 OST3 / OST6 family, transporter family Thioredoxin_7 PF13899.6 EGD96579.1 - 5.6e-08 32.9 0.0 0.00074 19.6 0.0 2.4 2 0 0 2 2 2 2 Thioredoxin-like Thioredoxin_8 PF13905.6 EGD96579.1 - 1.4e-06 28.5 0.0 0.41 11.0 0.0 3.9 3 1 1 4 4 4 2 Thioredoxin-like AhpC-TSA PF00578.21 EGD96579.1 - 4.1e-06 26.7 0.0 0.02 14.8 0.0 2.3 2 0 0 2 2 2 2 AhpC/TSA family TraF PF13728.6 EGD96579.1 - 3.9e-05 23.6 0.0 0.066 13.0 0.0 2.3 2 0 0 2 2 2 2 F plasmid transfer operon protein Thioredoxin_6 PF13848.6 EGD96579.1 - 0.0015 18.5 0.0 0.62 9.9 0.0 2.7 3 0 0 3 3 3 1 Thioredoxin-like domain Thioredoxin_9 PF14595.6 EGD96579.1 - 0.0022 17.7 0.2 0.25 11.1 0.0 3.0 3 0 0 3 3 3 1 Thioredoxin HyaE PF07449.11 EGD96579.1 - 0.0091 16.0 0.0 0.41 10.6 0.0 2.3 2 0 0 2 2 2 1 Hydrogenase-1 expression protein HyaE Glutaredoxin PF00462.24 EGD96579.1 - 0.0099 16.1 0.0 5.8 7.2 0.1 3.0 2 1 0 2 2 2 1 Glutaredoxin OrfB_IS605 PF01385.19 EGD96579.1 - 0.065 13.5 0.4 0.13 12.5 0.4 1.4 1 0 0 1 1 1 0 Probable transposase Thioredoxin_4 PF13462.6 EGD96579.1 - 0.24 11.5 3.7 66 3.6 0.0 3.8 3 1 1 4 4 4 0 Thioredoxin HSBP1 PF06825.12 EGD96580.1 - 8.1e-20 70.4 2.5 1e-19 70.1 2.5 1.1 1 0 0 1 1 1 1 Heat shock factor binding protein 1 CLZ PF16526.5 EGD96580.1 - 5.7e-05 23.4 1.7 6.9e-05 23.1 1.7 1.1 1 0 0 1 1 1 1 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Matrilin_ccoil PF10393.9 EGD96580.1 - 0.0001 22.1 0.5 0.00082 19.2 0.5 2.1 1 1 0 1 1 1 1 Trimeric coiled-coil oligomerisation domain of matrilin NPV_P10 PF05531.12 EGD96580.1 - 0.00062 20.2 1.5 0.00079 19.8 1.5 1.2 1 0 0 1 1 1 1 Nucleopolyhedrovirus P10 protein Laminin_II PF06009.12 EGD96580.1 - 0.0019 18.2 0.6 0.0022 18.0 0.6 1.1 1 0 0 1 1 1 1 Laminin Domain II DUF3235 PF11574.8 EGD96580.1 - 0.0026 18.6 0.4 0.0031 18.3 0.4 1.2 1 1 0 1 1 1 1 Protein of unknown function (DUF3235) Baculo_PEP_C PF04513.12 EGD96580.1 - 0.005 16.9 0.8 0.0062 16.6 0.8 1.1 1 0 0 1 1 1 1 Baculovirus polyhedron envelope protein, PEP, C terminus BORCS6 PF10157.9 EGD96580.1 - 0.02 15.1 0.4 0.021 15.0 0.4 1.2 1 0 0 1 1 1 0 BLOC-1-related complex sub-unit 6 XhlA PF10779.9 EGD96580.1 - 0.076 13.2 0.4 0.22 11.8 0.1 1.7 1 1 1 2 2 2 0 Haemolysin XhlA Zw10 PF06248.13 EGD96580.1 - 0.077 11.5 0.8 0.084 11.4 0.8 1.0 1 0 0 1 1 1 0 Centromere/kinetochore Zw10 DUF3450 PF11932.8 EGD96580.1 - 0.092 12.0 3.2 0.12 11.7 3.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) Fzo_mitofusin PF04799.13 EGD96580.1 - 0.1 12.1 1.1 0.11 12.1 1.1 1.1 1 0 0 1 1 1 0 fzo-like conserved region Prominin PF05478.11 EGD96580.1 - 0.12 10.3 0.3 0.13 10.2 0.3 1.0 1 0 0 1 1 1 0 Prominin Ebp2 PF05890.12 EGD96581.1 - 3.5e-94 315.3 14.8 3.5e-94 315.3 14.8 2.2 1 1 1 2 2 2 1 Eukaryotic rRNA processing protein EBP2 DNMT1-RFD PF12047.8 EGD96582.1 - 0.0017 18.4 0.1 0.0085 16.1 0.0 2.2 2 0 0 2 2 2 1 Cytosine specific DNA methyltransferase replication foci domain Neuregulin PF02158.15 EGD96582.1 - 0.0027 17.1 3.5 0.0044 16.4 3.5 1.2 1 0 0 1 1 1 1 Neuregulin intracellular region Drc1-Sld2 PF11719.8 EGD96582.1 - 0.0037 16.9 5.0 0.0037 16.9 5.0 1.6 2 0 0 2 2 2 1 DNA replication and checkpoint protein E3_UbLigase_EDD PF11547.8 EGD96582.1 - 0.015 15.0 1.2 0.045 13.5 1.2 1.7 1 0 0 1 1 1 0 E3 ubiquitin ligase EDD RNase_T PF00929.24 EGD96582.1 - 0.038 14.5 0.0 0.082 13.4 0.0 1.5 1 0 0 1 1 1 0 Exonuclease TruB_N PF01509.18 EGD96583.1 - 3.8e-19 69.5 0.0 2.9e-18 66.7 0.0 2.2 2 1 1 3 3 3 1 TruB family pseudouridylate synthase (N terminal domain) TruB_C_2 PF16198.5 EGD96583.1 - 7.7e-07 29.2 0.0 1.9e-06 27.9 0.0 1.6 2 0 0 2 2 2 1 tRNA pseudouridylate synthase B C-terminal domain SWIRM-assoc_2 PF16496.5 EGD96583.1 - 0.49 9.2 7.7 0.66 8.8 7.7 1.2 1 0 0 1 1 1 0 SWIRM-associated domain at the N-terminal TcdA_TcdB_pore PF12920.7 EGD96585.1 - 0.07 11.4 0.0 0.079 11.2 0.0 1.0 1 0 0 1 1 1 0 TcdA/TcdB pore forming domain OHCU_decarbox PF09349.10 EGD96587.1 - 6.3e-45 153.4 0.1 7.3e-45 153.2 0.1 1.0 1 0 0 1 1 1 1 OHCU decarboxylase DUF3684 PF12449.8 EGD96587.1 - 0.028 12.2 0.0 0.051 11.4 0.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3684) WD40 PF00400.32 EGD96588.1 - 2.7e-19 69.1 4.6 7.9e-05 23.4 0.2 6.2 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EGD96588.1 - 0.00084 19.6 0.0 3.6 7.9 0.0 4.0 2 2 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EGD96588.1 - 0.014 14.0 0.1 0.4 9.3 0.2 2.2 1 1 1 2 2 2 0 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 EGD96588.1 - 0.03 12.9 0.0 0.067 11.7 0.0 1.5 1 1 0 1 1 1 0 Cytochrome D1 heme domain CBM_19 PF03427.13 EGD96588.1 - 0.23 11.5 3.2 0.28 11.2 0.0 2.7 3 0 0 3 3 3 0 Carbohydrate binding domain (family 19) Nudix_N_2 PF14803.6 EGD96588.1 - 1.3 9.0 4.5 13 5.8 5.6 2.1 2 0 0 2 2 2 0 Nudix N-terminal SRP9-21 PF05486.12 EGD96589.1 - 4.4e-33 113.5 1.5 5.8e-33 113.2 1.5 1.2 1 0 0 1 1 1 1 Signal recognition particle 9 kDa protein (SRP9) K_channel_TID PF07941.11 EGD96589.1 - 0.026 15.0 1.6 1.4 9.4 0.2 2.2 2 0 0 2 2 2 0 Potassium channel Kv1.4 tandem inactivation domain Ribonuc_red_sm PF00268.21 EGD96590.1 - 2.7e-121 404.3 2.2 3.3e-121 404.0 2.2 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, small chain Mito_carr PF00153.27 EGD96591.1 - 1.4e-51 172.3 3.6 9.1e-17 60.8 0.2 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein WD40 PF00400.32 EGD96592.1 - 7.3e-13 48.8 0.9 0.0002 22.1 0.1 5.4 6 0 0 6 6 6 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EGD96592.1 - 5.6e-06 26.6 0.0 0.0029 17.9 0.0 3.6 1 1 3 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain TruB_C PF09142.11 EGD96592.1 - 0.16 11.8 0.0 0.43 10.4 0.0 1.7 1 0 0 1 1 1 0 tRNA Pseudouridine synthase II, C terminal Frtz PF11768.8 EGD96592.1 - 0.23 9.7 0.0 0.44 8.8 0.0 1.3 1 0 0 1 1 1 0 WD repeat-containing and planar cell polarity effector protein Fritz DUF1308 PF07000.11 EGD96593.1 - 1.6e-14 54.2 0.0 1e-13 51.6 0.0 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF1308) DUF2408 PF10303.9 EGD96593.1 - 0.12 12.9 1.3 0.34 11.5 0.2 2.3 2 1 1 3 3 3 0 Protein of unknown function (DUF2408) Lung_7-TM_R PF06814.13 EGD96594.1 - 8.7e-73 245.1 19.7 1e-72 244.9 19.7 1.1 1 0 0 1 1 1 1 Lung seven transmembrane receptor SurA_N_3 PF13624.6 EGD96594.1 - 3.4 7.4 4.6 2.5 7.9 0.2 2.3 2 0 0 2 2 2 0 SurA N-terminal domain CTU2 PF10288.9 EGD96595.1 - 8.5e-10 38.9 0.3 8.5e-10 38.9 0.3 2.2 2 1 0 2 2 2 1 Cytoplasmic tRNA 2-thiolation protein 2 DUF4112 PF13430.6 EGD96596.1 - 3e-36 123.9 0.3 3.9e-36 123.5 0.3 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4112) AgrD PF05931.11 EGD96596.1 - 0.088 12.9 0.4 0.19 11.8 0.4 1.5 1 0 0 1 1 1 0 Staphylococcal AgrD protein DCP2 PF05026.13 EGD96597.1 - 3.9e-31 107.2 1.4 7e-31 106.4 1.4 1.4 1 0 0 1 1 1 1 Dcp2, box A domain NUDIX PF00293.28 EGD96597.1 - 8.5e-17 61.4 0.1 1.6e-16 60.6 0.1 1.4 1 0 0 1 1 1 1 NUDIX domain GCV_T PF01571.21 EGD96599.1 - 8.7e-05 22.0 0.0 0.00013 21.4 0.0 1.2 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain Mei4 PF13971.6 EGD96600.1 - 0.0032 17.1 0.1 0.0059 16.2 0.1 1.4 1 0 0 1 1 1 1 Meiosis-specific protein Mei4 DnaJ PF00226.31 EGD96601.1 - 1e-19 70.4 0.0 2.5e-19 69.1 0.0 1.7 1 0 0 1 1 1 1 DnaJ domain RRM_1 PF00076.22 EGD96601.1 - 0.032 14.1 0.2 0.088 12.6 0.2 1.8 1 1 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PIG-L PF02585.17 EGD96603.1 - 2.3e-28 99.4 0.0 3.3e-28 98.9 0.0 1.2 1 0 0 1 1 1 1 GlcNAc-PI de-N-acetylase ATP13 PF12921.7 EGD96604.1 - 5.6e-27 93.9 0.0 1.2e-26 92.8 0.0 1.6 1 0 0 1 1 1 1 Mitochondrial ATPase expression PPR_3 PF13812.6 EGD96604.1 - 1.4e-07 31.5 0.0 7.4e-06 26.0 0.0 2.5 2 0 0 2 2 2 1 Pentatricopeptide repeat domain PPR_2 PF13041.6 EGD96604.1 - 9.6e-06 25.7 0.1 0.15 12.3 0.1 3.3 4 0 0 4 4 4 2 PPR repeat family Csc2 PF18320.1 EGD96604.1 - 0.0059 15.6 0.0 0.0096 14.9 0.0 1.2 1 0 0 1 1 1 1 Csc2 Crispr FCD PF07729.12 EGD96604.1 - 0.0086 16.5 0.7 0.018 15.5 0.7 1.5 1 0 0 1 1 1 1 FCD domain PPR PF01535.20 EGD96604.1 - 0.026 14.8 0.3 8.7 6.8 0.1 3.5 3 0 0 3 3 3 0 PPR repeat DUF1216 PF06746.11 EGD96604.1 - 0.13 12.3 1.0 0.29 11.1 1.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1216) GTP_EFTU PF00009.27 EGD96605.1 - 1.2e-19 70.6 0.1 4.3e-19 68.8 0.1 1.8 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain LSM PF01423.22 EGD96605.1 - 2.4e-13 49.5 0.2 8.6e-13 47.8 0.2 2.0 1 0 0 1 1 1 1 LSM domain GTP_EFTU_D2 PF03144.25 EGD96605.1 - 7.4e-07 29.5 1.3 4e-06 27.1 0.7 2.7 2 0 0 2 2 2 1 Elongation factor Tu domain 2 GTP_EFTU_D3 PF03143.17 EGD96605.1 - 4.5e-05 23.7 0.0 0.00013 22.3 0.0 1.8 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain MMR_HSR1 PF01926.23 EGD96605.1 - 0.003 17.6 0.0 0.0077 16.3 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EGD96605.1 - 0.0083 16.1 0.1 5.1 7.0 0.1 2.4 2 0 0 2 2 2 2 RsgA GTPase PduV-EutP PF10662.9 EGD96605.1 - 0.014 15.2 0.3 3.8 7.2 0.0 3.2 2 1 1 3 3 3 0 Ethanolamine utilisation - propanediol utilisation Roc PF08477.13 EGD96605.1 - 0.088 13.0 0.2 1.3 9.3 0.1 2.4 1 1 1 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Dynamin_N PF00350.23 EGD96605.1 - 0.12 12.4 0.4 0.48 10.5 0.2 2.1 2 0 0 2 2 2 0 Dynamin family FtsK_SpoIIIE PF01580.18 EGD96605.1 - 0.14 11.5 0.0 0.4 10.0 0.0 1.7 2 0 0 2 2 2 0 FtsK/SpoIIIE family Lyase_1 PF00206.20 EGD96607.1 - 5e-22 78.7 0.1 9.1e-22 77.8 0.1 1.3 1 0 0 1 1 1 1 Lyase ADSL_C PF10397.9 EGD96607.1 - 3.2e-17 62.8 0.0 9.3e-17 61.3 0.0 1.9 1 0 0 1 1 1 1 Adenylosuccinate lyase C-terminus SNF2_N PF00176.23 EGD96608.1 - 3.6e-71 239.7 0.0 4.8e-71 239.3 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain HIRAN PF08797.11 EGD96608.1 - 8.1e-25 86.6 0.0 1.6e-24 85.6 0.0 1.5 1 0 0 1 1 1 1 HIRAN domain Helicase_C PF00271.31 EGD96608.1 - 4.1e-13 49.6 0.0 1.1e-12 48.3 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EGD96608.1 - 1.6e-07 31.5 0.0 3.6e-07 30.3 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit zf-C3HC4_3 PF13920.6 EGD96608.1 - 0.0002 21.2 9.5 0.00037 20.3 9.5 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EGD96608.1 - 0.0012 18.7 5.0 0.0029 17.4 5.0 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EGD96608.1 - 0.0019 18.0 12.6 0.004 17.0 12.6 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EGD96608.1 - 0.0083 16.1 11.3 0.022 14.8 11.3 1.8 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 EGD96608.1 - 0.06 13.3 11.0 0.14 12.2 11.0 1.6 1 0 0 1 1 1 0 zinc-RING finger domain zf-RING_2 PF13639.6 EGD96608.1 - 0.088 13.2 13.3 0.11 12.9 11.9 2.0 2 0 0 2 2 1 0 Ring finger domain zf-C3HC4_5 PF17121.5 EGD96608.1 - 0.45 10.4 3.3 1 9.3 3.3 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EGD96608.1 - 0.69 10.1 12.4 1.5 9.1 12.4 1.5 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 EGD96608.1 - 1.7 8.6 11.8 10 6.1 12.0 2.2 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 SQS_PSY PF00494.19 EGD96609.1 - 1.9e-50 171.8 0.0 3.4e-50 171.0 0.0 1.4 1 1 0 1 1 1 1 Squalene/phytoene synthase Soyouz_module PF14313.6 EGD96609.1 - 0.046 13.5 0.0 0.088 12.6 0.0 1.4 1 0 0 1 1 1 0 N-terminal region of Paramyxovirinae phosphoprotein (P) CorA PF01544.18 EGD96610.1 - 7.7e-24 84.5 6.3 2.2e-16 60.0 1.1 3.1 3 0 0 3 3 3 3 CorA-like Mg2+ transporter protein DNApol_Exo PF18136.1 EGD96611.1 - 2.1e-104 348.7 0.1 3.5e-104 347.9 0.1 1.4 1 0 0 1 1 1 1 DNA mitochondrial polymerase exonuclease domain DNA_pol_A PF00476.20 EGD96611.1 - 2.9e-57 194.4 0.0 4.9e-57 193.7 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase family A TFIIS_M PF07500.14 EGD96611.1 - 0.029 14.9 0.9 0.1 13.1 0.9 1.9 1 0 0 1 1 1 0 Transcription factor S-II (TFIIS), central domain DNA_pol_A_exo1 PF01612.20 EGD96611.1 - 0.041 13.6 0.1 0.72 9.5 0.1 2.4 1 1 0 1 1 1 0 3'-5' exonuclease Mad3_BUB1_I PF08311.12 EGD96611.1 - 0.1 12.5 0.2 0.25 11.3 0.2 1.5 1 0 0 1 1 1 0 Mad3/BUB1 homology region 1 zf-C3HC4_2 PF13923.6 EGD96612.1 - 5.2e-09 35.8 7.5 8.6e-09 35.1 3.7 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EGD96612.1 - 6.9e-09 35.4 4.2 2e-08 33.9 4.4 1.7 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EGD96612.1 - 4.7e-08 33.2 4.6 7.4e-08 32.6 4.6 1.3 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 EGD96612.1 - 5.8e-08 32.6 6.0 2.9e-07 30.4 1.8 2.3 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 EGD96612.1 - 1.4e-07 31.2 8.4 4.2e-07 29.7 8.4 1.7 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EGD96612.1 - 8.5e-07 28.8 5.2 1.6e-06 28.0 5.2 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 EGD96612.1 - 3.2e-06 27.2 6.4 3.1e-05 24.0 7.0 2.0 1 1 1 2 2 2 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 EGD96612.1 - 8.3e-05 22.4 6.6 0.00041 20.1 6.7 2.1 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 zf-Nse PF11789.8 EGD96612.1 - 0.047 13.5 1.3 0.11 12.3 1.3 1.6 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit RNHCP PF12647.7 EGD96612.1 - 0.057 13.4 1.9 8.9 6.4 0.1 2.4 1 1 1 2 2 2 0 RNHCP domain Rad50_zn_hook PF04423.14 EGD96612.1 - 0.08 12.8 0.5 2.7 7.9 0.1 2.4 2 0 0 2 2 2 0 Rad50 zinc hook motif DUF2616 PF11077.8 EGD96612.1 - 0.16 11.7 0.9 0.26 11.0 0.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2616) FANCL_C PF11793.8 EGD96612.1 - 0.17 12.1 3.2 0.82 9.9 3.3 2.0 1 1 1 2 2 2 0 FANCL C-terminal domain zf-rbx1 PF12678.7 EGD96612.1 - 0.18 12.1 5.9 0.6 10.4 5.9 1.9 1 1 0 1 1 1 0 RING-H2 zinc finger domain DUF1644 PF07800.12 EGD96612.1 - 0.32 11.0 6.1 0.92 9.6 2.2 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1644) zf-ANAPC11 PF12861.7 EGD96612.1 - 0.34 11.0 3.6 2.1 8.4 3.6 2.0 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_6 PF14835.6 EGD96612.1 - 0.59 10.1 4.3 0.48 10.3 1.4 2.1 2 0 0 2 2 2 0 zf-RING of BARD1-type protein zf-RING_4 PF14570.6 EGD96612.1 - 3.6 7.5 7.3 21 5.0 7.4 2.1 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain UPF0052 PF01933.18 EGD96613.1 - 2.3e-58 197.8 0.0 3.2e-58 197.3 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised protein family UPF0052 PI3_PI4_kinase PF00454.27 EGD96614.1 - 2.3e-49 168.4 0.0 4.8e-49 167.4 0.0 1.5 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase TAN PF11640.8 EGD96614.1 - 5.2e-45 153.3 0.1 1.6e-44 151.7 0.1 2.0 1 0 0 1 1 1 1 Telomere-length maintenance and DNA damage repair FATC PF02260.20 EGD96614.1 - 4.8e-08 32.7 0.1 1.1e-07 31.5 0.1 1.7 1 0 0 1 1 1 1 FATC domain FAT PF02259.23 EGD96614.1 - 5.8e-05 22.5 1.4 0.00014 21.2 1.4 1.6 1 0 0 1 1 1 1 FAT domain Nup192 PF11894.8 EGD96615.1 - 0 1285.5 20.8 0 1285.2 20.8 1.0 1 0 0 1 1 1 1 Nuclear pore complex scaffold, nucleoporins 186/192/205 Cullin PF00888.22 EGD96616.1 - 6.9e-174 579.9 3.6 8.5e-174 579.6 3.6 1.1 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 EGD96616.1 - 3.9e-24 84.5 1.7 1.2e-23 82.9 1.7 1.9 1 0 0 1 1 1 1 Cullin protein neddylation domain HbrB PF08539.11 EGD96616.1 - 0.049 13.6 0.0 0.18 11.8 0.0 2.0 1 0 0 1 1 1 0 HbrB-like Dak1 PF02733.17 EGD96617.1 - 8.4e-106 353.4 1.9 1.2e-105 352.9 1.9 1.2 1 0 0 1 1 1 1 Dak1 domain Dak2 PF02734.17 EGD96617.1 - 1e-48 165.5 0.6 4.6e-48 163.4 0.4 2.1 2 0 0 2 2 2 1 DAK2 domain LSM PF01423.22 EGD96618.1 - 1.1e-14 53.9 0.4 1e-13 50.7 0.4 2.0 1 1 0 1 1 1 1 LSM domain GATA PF00320.27 EGD96619.1 - 1.1e-05 24.9 3.4 0.0011 18.5 0.3 2.6 2 0 0 2 2 2 2 GATA zinc finger zf-RING_7 PF02591.15 EGD96619.1 - 0.2 11.9 1.6 0.38 11.0 0.7 2.0 2 0 0 2 2 2 0 C4-type zinc ribbon domain Rep_fac-A_3 PF08661.11 EGD96620.1 - 2e-22 79.5 0.0 2.3e-22 79.3 0.0 1.0 1 0 0 1 1 1 1 Replication factor A protein 3 Glyco_hydro_16 PF00722.21 EGD96621.1 - 4.1e-45 153.4 1.8 6.2e-45 152.8 1.8 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 MFAP1 PF06991.11 EGD96622.1 - 1.2e-41 143.0 14.2 1.2e-41 143.0 14.2 3.2 3 1 0 3 3 3 1 Microfibril-associated/Pre-mRNA processing TRAPP PF04051.16 EGD96623.1 - 5.5e-39 133.2 0.0 7.7e-39 132.7 0.0 1.2 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component NAD_kinase PF01513.21 EGD96624.1 - 1.8e-74 250.6 0.0 2.3e-74 250.2 0.0 1.2 1 0 0 1 1 1 1 ATP-NAD kinase tRNA_synt_1c_R2 PF04557.15 EGD96628.1 - 1.2 10.1 12.5 5.3 8.0 4.3 2.1 2 0 0 2 2 2 0 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 OAD_gamma PF04277.13 EGD96628.1 - 1.3 9.7 4.9 12 6.6 1.1 2.2 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain SR-25 PF10500.9 EGD96628.1 - 1.5 8.4 32.9 3.3 7.3 32.9 1.5 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein Menin PF05053.13 EGD96628.1 - 2 6.7 6.6 2.3 6.5 6.6 1.0 1 0 0 1 1 1 0 Menin Las1 PF04031.13 EGD96630.1 - 1.3e-39 135.8 0.7 3.5e-39 134.4 0.7 1.8 1 1 0 1 1 1 1 Las1-like HAGH_C PF16123.5 EGD96631.1 - 6.8e-21 74.6 0.9 1e-20 74.0 0.9 1.3 1 0 0 1 1 1 1 Hydroxyacylglutathione hydrolase C-terminus Lactamase_B PF00753.27 EGD96631.1 - 3.6e-17 63.0 5.6 3.1e-16 60.0 5.6 2.0 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EGD96631.1 - 0.012 15.2 4.4 0.14 11.6 4.2 2.4 1 1 0 1 1 1 0 Beta-lactamase superfamily domain BcrAD_BadFG PF01869.20 EGD96631.1 - 0.038 13.5 0.1 0.12 11.8 0.0 1.7 2 0 0 2 2 2 0 BadF/BadG/BcrA/BcrD ATPase family Peptidase_S24 PF00717.23 EGD96632.1 - 4.2e-09 36.2 0.1 7.3e-09 35.5 0.1 1.3 1 0 0 1 1 1 1 Peptidase S24-like Peptidase_S26 PF10502.9 EGD96632.1 - 0.00034 20.4 0.0 0.0098 15.7 0.0 2.3 1 1 0 1 1 1 1 Signal peptidase, peptidase S26 PBP PF01161.20 EGD96633.1 - 2.8e-06 27.7 0.0 4.6e-06 27.0 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein ABC_tran_Xtn PF12848.7 EGD96633.1 - 0.37 10.9 6.1 0.9 9.6 6.1 1.6 1 0 0 1 1 1 0 ABC transporter Ribosomal_L4 PF00573.22 EGD96634.1 - 4.5e-46 157.0 0.0 7.1e-46 156.3 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family Sde2_N_Ubi PF13019.6 EGD96634.1 - 0.11 12.3 0.2 0.2 11.5 0.2 1.3 1 0 0 1 1 1 0 Silencing defective 2 N-terminal ubiquitin domain ECH_2 PF16113.5 EGD96635.1 - 1.4e-121 406.1 0.0 1.9e-121 405.7 0.0 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_1 PF00378.20 EGD96635.1 - 4.6e-22 78.6 0.1 4.9e-21 75.2 0.0 2.3 2 1 0 2 2 2 1 Enoyl-CoA hydratase/isomerase RhoGAP PF00620.27 EGD96636.1 - 0.13 12.0 0.0 0.24 11.2 0.0 1.5 1 0 0 1 1 1 0 RhoGAP domain CBS PF00571.28 EGD96637.1 - 6.8e-22 77.7 7.8 1.3e-08 35.2 0.4 4.3 4 0 0 4 4 4 4 CBS domain CRAL_TRIO PF00650.20 EGD96638.1 - 1.8e-36 125.3 0.0 2.5e-36 124.8 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 EGD96638.1 - 5.6e-14 52.1 0.0 1.4e-13 50.8 0.0 1.7 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.6 EGD96638.1 - 0.0005 20.3 0.0 0.00073 19.7 0.0 1.2 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain Pol_alpha_B_N PF08418.10 EGD96639.1 - 3e-79 266.5 0.4 3.8e-79 266.1 0.4 1.1 1 0 0 1 1 1 1 DNA polymerase alpha subunit B N-terminal DNA_pol_E_B PF04042.16 EGD96639.1 - 2.2e-34 118.6 0.0 3.2e-34 118.1 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B Apc13p PF05839.11 EGD96640.1 - 3.8e-20 71.9 1.0 5.7e-17 61.7 0.1 2.2 1 1 0 2 2 2 2 Apc13p protein IF-2B PF01008.17 EGD96641.1 - 5.9e-70 235.7 0.1 7.6e-70 235.3 0.1 1.1 1 0 0 1 1 1 1 Initiation factor 2 subunit family Kinesin PF00225.23 EGD96642.1 - 1.1e-112 376.3 0.0 1.8e-112 375.5 0.0 1.3 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EGD96642.1 - 7.2e-26 90.9 0.9 1.3e-25 90.0 0.0 1.8 2 0 0 2 2 2 1 Microtubule binding DUF1460 PF07313.12 EGD96642.1 - 0.043 13.2 1.3 0.087 12.2 1.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1460) DUF5094 PF17015.5 EGD96642.1 - 0.095 12.8 5.9 0.23 11.6 5.9 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5094) FUSC PF04632.12 EGD96642.1 - 0.1 11.1 2.6 0.094 11.2 0.7 1.7 1 1 0 1 1 1 0 Fusaric acid resistance protein family Spc7 PF08317.11 EGD96642.1 - 0.11 11.4 10.8 0.21 10.4 10.8 1.4 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF87 PF01935.17 EGD96642.1 - 1.5 8.8 9.6 0.86 9.6 0.1 2.9 3 0 0 3 3 3 0 Helicase HerA, central domain YabA PF06156.13 EGD96642.1 - 1.8 9.2 12.7 28 5.4 7.4 3.1 3 1 0 3 3 3 0 Initiation control protein YabA PUL PF08324.11 EGD96643.1 - 1e-56 192.2 1.1 1.6e-56 191.6 1.1 1.3 1 0 0 1 1 1 1 PUL domain Peptidase_C97 PF05903.14 EGD96643.1 - 5e-40 136.8 0.0 8.8e-40 136.0 0.0 1.4 1 0 0 1 1 1 1 PPPDE putative peptidase domain Thioredoxin PF00085.20 EGD96643.1 - 4e-15 55.7 0.0 7.7e-15 54.7 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin TraF PF13728.6 EGD96643.1 - 3.4e-05 23.8 0.0 5.7e-05 23.1 0.0 1.2 1 0 0 1 1 1 1 F plasmid transfer operon protein Thioredoxin_2 PF13098.6 EGD96643.1 - 0.00036 21.0 0.3 0.0014 19.0 0.3 1.9 1 1 0 1 1 1 1 Thioredoxin-like domain OST3_OST6 PF04756.13 EGD96643.1 - 0.0084 15.5 0.0 0.012 15.0 0.0 1.2 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_3 PF13192.6 EGD96643.1 - 0.014 15.5 0.0 0.036 14.1 0.0 1.6 1 0 0 1 1 1 0 Thioredoxin domain Redoxin PF08534.10 EGD96643.1 - 0.032 14.0 0.0 0.083 12.6 0.0 1.7 1 0 0 1 1 1 0 Redoxin AhpC-TSA PF00578.21 EGD96643.1 - 0.034 14.0 0.0 0.11 12.4 0.0 1.8 2 0 0 2 2 2 0 AhpC/TSA family DSBA PF01323.20 EGD96643.1 - 0.056 13.2 0.0 1.3 8.7 0.0 2.2 1 1 1 2 2 2 0 DSBA-like thioredoxin domain DUF2847 PF11009.8 EGD96643.1 - 0.18 11.8 0.0 0.37 10.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2847) EF-hand_9 PF14658.6 EGD96644.1 - 0.0016 18.7 0.0 0.77 10.1 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 EGD96644.1 - 0.038 13.9 0.0 0.23 11.3 0.0 2.3 2 0 0 2 2 2 0 EF-hand domain pair Dak2 PF02734.17 EGD96644.1 - 0.074 13.0 0.0 0.15 11.9 0.0 1.5 1 1 0 1 1 1 0 DAK2 domain UCH PF00443.29 EGD96645.1 - 6.4e-29 101.2 0.0 3.2e-28 98.9 0.0 2.0 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EGD96645.1 - 6.5e-07 29.3 1.1 1.4e-05 24.8 1.1 2.2 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Alb1 PF09135.11 EGD96646.1 - 3.5e-31 108.2 10.5 5.6e-31 107.5 10.5 1.3 1 0 0 1 1 1 1 Alb1 CTX_RstB PF07459.11 EGD96646.1 - 0.13 12.5 0.2 0.31 11.3 0.2 1.6 1 1 0 1 1 1 0 CTX phage RstB protein Vps16_N PF04841.13 EGD96647.1 - 2e-98 329.9 0.0 3.1e-98 329.3 0.0 1.3 1 0 0 1 1 1 1 Vps16, N-terminal region Vps16_C PF04840.12 EGD96647.1 - 6.9e-89 298.0 0.4 1e-88 297.5 0.4 1.2 1 0 0 1 1 1 1 Vps16, C-terminal region ANAPC4_WD40 PF12894.7 EGD96647.1 - 2.9e-05 24.3 0.0 0.0019 18.5 0.0 2.6 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain AAA_lid_2 PF17863.1 EGD96648.1 - 8.5e-05 22.3 0.0 0.00017 21.4 0.0 1.5 1 0 0 1 1 1 1 AAA lid domain IGF2_C PF08365.11 EGD96649.1 - 1.7 8.7 5.3 24 5.0 0.5 3.3 3 0 0 3 3 3 0 Insulin-like growth factor II E-peptide Bestrophin PF01062.21 EGD96650.1 - 7.2e-58 196.3 0.0 9.2e-58 196.0 0.0 1.0 1 0 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel FHA PF00498.26 EGD96651.1 - 2.6e-14 53.3 0.0 5e-14 52.4 0.0 1.5 1 0 0 1 1 1 1 FHA domain zf-RING_11 PF17123.5 EGD96651.1 - 2.6e-10 39.9 4.2 5e-10 38.9 4.2 1.5 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_2 PF13639.6 EGD96651.1 - 8.1e-07 29.3 8.8 1.5e-06 28.4 8.8 1.5 1 0 0 1 1 1 1 Ring finger domain Yop-YscD_cpl PF16697.5 EGD96651.1 - 0.00034 20.9 0.0 0.00076 19.7 0.0 1.5 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain zf-RING_5 PF14634.6 EGD96651.1 - 0.0013 18.7 6.7 0.0025 17.7 6.7 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 EGD96651.1 - 0.012 15.5 8.1 0.023 14.6 8.1 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EGD96651.1 - 0.018 14.9 8.7 0.035 14.0 8.7 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING-like PF08746.11 EGD96651.1 - 0.02 15.2 5.5 0.046 14.0 5.5 1.7 1 0 0 1 1 1 0 RING-like domain zf-ANAPC11 PF12861.7 EGD96651.1 - 0.049 13.7 2.9 0.1 12.7 2.9 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.7 EGD96651.1 - 0.14 12.5 8.2 0.39 11.0 8.2 1.8 1 0 0 1 1 1 0 RING-H2 zinc finger domain PHD PF00628.29 EGD96651.1 - 0.2 11.5 5.6 0.41 10.6 5.6 1.5 1 0 0 1 1 1 0 PHD-finger zf-H2C2_2 PF13465.6 EGD96651.1 - 1.7 9.2 3.6 1.4 9.5 0.8 2.4 2 0 0 2 2 1 0 Zinc-finger double domain TFIIA PF03153.13 EGD96651.1 - 3.1 7.7 26.0 0.099 12.6 5.0 2.2 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Zn_ribbon_17 PF17120.5 EGD96651.1 - 3.8 7.2 8.1 7.8 6.2 8.1 1.5 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-C3HC4_4 PF15227.6 EGD96651.1 - 5.3 7.3 7.5 8.6 6.6 6.8 1.8 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING Arm PF00514.23 EGD96653.1 - 1.1e-70 231.7 26.4 3.6e-11 42.7 0.1 11.2 11 0 0 11 11 11 9 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 EGD96653.1 - 2.7e-17 62.9 18.8 5.4e-05 23.6 0.2 7.7 6 3 3 9 9 8 5 HEAT-like repeat HEAT PF02985.22 EGD96653.1 - 8e-15 53.7 15.4 0.24 11.8 0.2 9.0 10 0 0 10 10 9 4 HEAT repeat HEAT_2 PF13646.6 EGD96653.1 - 1e-14 54.7 12.4 0.00016 22.0 0.1 7.0 3 3 3 6 6 6 3 HEAT repeats Adaptin_N PF01602.20 EGD96653.1 - 9.9e-14 50.8 6.2 2.8e-08 32.8 0.2 2.6 1 1 1 2 2 2 2 Adaptin N terminal region Arm_2 PF04826.13 EGD96653.1 - 2.9e-09 36.8 4.7 1.5e-05 24.6 2.0 2.5 1 1 1 2 2 2 2 Armadillo-like KAP PF05804.12 EGD96653.1 - 3.5e-09 35.4 0.4 8.2e-09 34.2 0.1 1.7 1 1 1 2 2 2 1 Kinesin-associated protein (KAP) V-ATPase_H_N PF03224.14 EGD96653.1 - 4.5e-08 32.8 0.6 0.00059 19.2 0.9 2.8 2 1 1 3 3 3 2 V-ATPase subunit H DUF5578 PF17741.1 EGD96653.1 - 0.0003 20.3 7.5 0.47 9.8 0.0 4.7 2 1 3 6 6 6 1 Family of unknown function (DUF5578) Atx10homo_assoc PF09759.9 EGD96653.1 - 0.00072 19.5 2.7 1.7 8.7 0.0 4.7 4 1 1 5 5 5 1 Spinocerebellar ataxia type 10 protein domain Cnd1 PF12717.7 EGD96653.1 - 0.00073 19.6 5.8 0.042 13.9 0.6 4.4 2 2 3 5 5 5 2 non-SMC mitotic condensation complex subunit 1 DUF3361 PF11841.8 EGD96653.1 - 0.0013 18.7 6.1 1.1 9.1 0.0 4.2 2 1 3 5 5 5 1 Domain of unknown function (DUF3361) HEAT_PBS PF03130.16 EGD96653.1 - 0.0015 19.0 8.7 1.2 10.0 0.5 6.6 6 0 0 6 6 6 1 PBS lyase HEAT-like repeat V-ATPase_H_C PF11698.8 EGD96653.1 - 0.0018 18.3 1.6 30 4.8 0.0 4.8 2 1 5 7 7 7 0 V-ATPase subunit H UNC45-central PF11701.8 EGD96653.1 - 0.011 15.6 1.3 1.3 9.0 0.1 3.1 3 1 0 3 3 3 0 Myosin-binding striated muscle assembly central Vac14_Fab1_bd PF12755.7 EGD96653.1 - 0.039 14.6 0.1 0.67 10.6 0.1 2.8 1 1 2 3 3 3 0 Vacuolar 14 Fab1-binding region EXOSC1 PF10447.9 EGD96654.1 - 7.4e-28 97.3 4.5 1.1e-27 96.8 4.5 1.3 1 0 0 1 1 1 1 Exosome component EXOSC1/CSL4 ECR1_N PF14382.6 EGD96654.1 - 2.6e-12 46.3 0.1 4.5e-12 45.6 0.1 1.4 1 0 0 1 1 1 1 Exosome complex exonuclease RRP4 N-terminal region PCB_OB PF17092.5 EGD96654.1 - 0.089 13.5 1.1 0.75 10.6 1.0 2.2 1 1 1 2 2 2 0 Penicillin-binding protein OB-like domain GTP_EFTU PF00009.27 EGD96655.1 - 2e-57 193.9 0.1 5.1e-57 192.6 0.0 1.7 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain EFG_C PF00679.24 EGD96655.1 - 4.7e-15 55.4 0.0 1.1e-14 54.1 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_II PF14492.6 EGD96655.1 - 4.4e-07 29.9 0.0 1e-06 28.7 0.0 1.6 1 0 0 1 1 1 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.25 EGD96655.1 - 6.7e-07 29.6 0.0 2e-06 28.1 0.0 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_IV PF03764.18 EGD96655.1 - 0.00012 21.9 0.0 0.00096 18.9 0.0 2.5 1 1 0 1 1 1 1 Elongation factor G, domain IV MMR_HSR1 PF01926.23 EGD96655.1 - 0.066 13.3 0.0 0.23 11.5 0.0 2.0 1 1 0 1 1 1 0 50S ribosome-binding GTPase DUF4604 PF15377.6 EGD96656.1 - 1.6e-24 87.3 15.1 1.7e-24 87.1 15.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4604) CheD PF03975.13 EGD96656.1 - 0.078 13.1 0.1 0.11 12.5 0.1 1.4 1 0 0 1 1 1 0 CheD chemotactic sensory transduction DRY_EERY PF09750.9 EGD96656.1 - 1.7 8.9 7.8 9 6.6 7.8 1.9 1 1 0 1 1 1 0 Alternative splicing regulator Prp19 PF08606.11 EGD96657.1 - 6.9e-33 112.5 0.5 1.3e-32 111.6 0.5 1.5 1 0 0 1 1 1 1 Prp19/Pso4-like ANAPC4_WD40 PF12894.7 EGD96657.1 - 5.5e-14 52.2 0.1 4.5e-07 30.1 0.0 4.7 1 1 4 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Coatomer_WDAD PF04053.14 EGD96657.1 - 3.4e-09 36.3 0.3 0.00029 20.0 0.0 2.1 1 1 1 2 2 2 2 Coatomer WD associated region WD40 PF00400.32 EGD96657.1 - 3.4e-09 37.2 12.3 3.3e-05 24.6 0.0 6.3 7 0 0 7 7 7 2 WD domain, G-beta repeat eIF2A PF08662.11 EGD96657.1 - 2.9e-05 24.0 0.0 0.05 13.5 0.0 2.9 1 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A V_ATPase_I_N PF18670.1 EGD96657.1 - 0.0007 19.9 0.3 0.0015 18.8 0.3 1.5 1 0 0 1 1 1 1 V-type ATPase subunit I, N-terminal domain Cytochrom_D1 PF02239.16 EGD96657.1 - 0.001 17.7 0.6 0.21 10.1 0.1 2.2 1 1 0 2 2 2 2 Cytochrome D1 heme domain WD40_like PF17005.5 EGD96657.1 - 0.0023 17.3 0.0 0.88 8.8 0.0 2.5 1 1 0 2 2 2 2 WD40-like domain Ge1_WD40 PF16529.5 EGD96657.1 - 0.015 14.3 0.1 0.043 12.8 0.1 1.7 1 1 0 1 1 1 0 WD40 region of Ge1, enhancer of mRNA-decapping protein zf-Nse PF11789.8 EGD96657.1 - 0.1 12.4 0.0 0.22 11.4 0.0 1.5 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit VID27 PF08553.10 EGD96657.1 - 0.11 11.5 0.1 0.19 10.7 0.1 1.3 1 0 0 1 1 1 0 VID27 C-terminal WD40-like domain Frtz PF11768.8 EGD96657.1 - 0.16 10.3 0.0 0.24 9.6 0.0 1.3 1 0 0 1 1 1 0 WD repeat-containing and planar cell polarity effector protein Fritz Cation_efflux PF01545.21 EGD96658.1 - 1.2e-54 185.1 4.3 2e-54 184.3 4.3 1.4 1 1 0 1 1 1 1 Cation efflux family DUF202 PF02656.15 EGD96659.1 - 4.8e-18 65.4 1.4 4.8e-18 65.4 1.4 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF202) Methyltransf_25 PF13649.6 EGD96660.1 - 5.9e-17 62.2 0.1 1.5e-16 60.9 0.1 1.7 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EGD96660.1 - 7.2e-16 58.6 0.1 1.3e-15 57.8 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EGD96660.1 - 4.7e-15 55.7 0.0 6.5e-15 55.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EGD96660.1 - 1.6e-12 48.0 0.0 2.9e-12 47.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EGD96660.1 - 3.2e-12 46.6 0.0 4.3e-12 46.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EGD96660.1 - 9.7e-07 28.4 0.0 1.6e-06 27.6 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.14 EGD96660.1 - 7.1e-06 25.7 0.0 1e-05 25.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain PCMT PF01135.19 EGD96660.1 - 1.1e-05 25.3 0.0 1.8e-05 24.6 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_9 PF08003.11 EGD96660.1 - 0.00021 20.4 0.0 0.00036 19.6 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) CMAS PF02353.20 EGD96660.1 - 0.00043 19.7 0.0 0.0006 19.2 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase NodS PF05401.11 EGD96660.1 - 0.0025 17.4 0.0 0.0037 16.9 0.0 1.2 1 0 0 1 1 1 1 Nodulation protein S (NodS) PrmA PF06325.13 EGD96660.1 - 0.022 14.2 0.0 0.032 13.6 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) MetW PF07021.12 EGD96660.1 - 0.036 13.7 0.0 0.059 13.0 0.0 1.2 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW FtsJ PF01728.19 EGD96660.1 - 0.042 14.0 0.1 0.43 10.7 0.1 2.1 1 1 0 1 1 1 0 FtsJ-like methyltransferase RrnaAD PF00398.20 EGD96660.1 - 0.052 12.6 0.0 0.074 12.1 0.0 1.1 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase Methyltransf_32 PF13679.6 EGD96660.1 - 0.06 13.3 0.0 0.094 12.7 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain DREV PF05219.12 EGD96660.1 - 0.077 12.1 0.0 0.11 11.5 0.0 1.2 1 0 0 1 1 1 0 DREV methyltransferase Methyltransf_5 PF01795.19 EGD96660.1 - 0.16 11.5 0.0 0.24 10.9 0.0 1.2 1 0 0 1 1 1 0 MraW methylase family DRE2_N PF16803.5 EGD96660.1 - 0.2 11.9 0.0 0.31 11.3 0.0 1.4 1 0 0 1 1 1 0 Fe-S cluster assembly protein DRE2 N-terminus M16C_assoc PF08367.11 EGD96661.1 - 2.1e-74 249.8 0.3 3.5e-74 249.1 0.3 1.4 1 0 0 1 1 1 1 Peptidase M16C associated Peptidase_M16_C PF05193.21 EGD96661.1 - 8.8e-24 84.5 0.0 8.5e-15 55.2 0.0 2.7 2 0 0 2 2 2 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 EGD96661.1 - 2.8e-10 40.4 0.0 1.8e-09 37.7 0.0 2.3 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) Taxilin PF09728.9 EGD96663.1 - 4.3e-93 311.9 51.4 4.3e-93 311.9 51.4 1.4 2 0 0 2 2 2 1 Myosin-like coiled-coil protein GOLGA2L5 PF15070.6 EGD96663.1 - 0.64 8.6 43.3 0.087 11.5 33.0 2.1 1 1 1 2 2 2 0 Putative golgin subfamily A member 2-like protein 5 DUF3675 PF12428.8 EGD96663.1 - 0.83 10.2 3.3 9.2 6.9 0.2 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3675) TPR_MLP1_2 PF07926.12 EGD96663.1 - 1.1 9.3 51.3 0.35 11.0 14.5 3.2 2 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein TMF_TATA_bd PF12325.8 EGD96663.1 - 1.3 9.2 52.1 0.6 10.3 12.4 4.3 2 2 2 4 4 4 0 TATA element modulatory factor 1 TATA binding COG2 PF06148.11 EGD96663.1 - 2 8.5 26.4 1.1 9.4 0.4 3.8 3 1 1 4 4 4 0 COG (conserved oligomeric Golgi) complex component, COG2 UPF0242 PF06785.11 EGD96663.1 - 2.6 8.1 56.1 0.82 9.7 8.7 4.5 1 1 3 4 4 4 0 Uncharacterised protein family (UPF0242) N-terminus DUF745 PF05335.13 EGD96663.1 - 3.8 7.2 24.8 2 8.1 5.5 3.2 2 2 1 3 3 3 0 Protein of unknown function (DUF745) DUF3450 PF11932.8 EGD96663.1 - 3.9 6.7 44.6 0.11 11.8 7.0 4.1 1 1 3 4 4 4 0 Protein of unknown function (DUF3450) Laminin_II PF06009.12 EGD96663.1 - 4.2 7.4 35.7 0.62 10.1 3.8 4.2 1 1 2 4 4 4 0 Laminin Domain II ERM PF00769.19 EGD96663.1 - 5.4 6.8 60.8 0.27 11.0 20.0 3.2 1 1 2 3 3 3 0 Ezrin/radixin/moesin family zf-C4H2 PF10146.9 EGD96663.1 - 6 7.1 34.3 0.21 11.9 8.8 3.1 2 1 1 3 3 3 0 Zinc finger-containing protein DUF3584 PF12128.8 EGD96663.1 - 7.5 3.9 49.7 24 2.3 11.3 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) NMO PF03060.15 EGD96664.1 - 9.8e-53 179.7 0.5 1.3e-52 179.3 0.5 1.1 1 0 0 1 1 1 1 Nitronate monooxygenase IMPDH PF00478.25 EGD96664.1 - 1.6e-06 27.4 1.2 2.1e-05 23.7 0.4 2.3 2 1 0 2 2 2 1 IMP dehydrogenase / GMP reductase domain FMN_dh PF01070.18 EGD96664.1 - 0.0027 16.8 3.5 0.0043 16.1 3.5 1.3 1 0 0 1 1 1 1 FMN-dependent dehydrogenase PEP_hydrolase PF09370.10 EGD96664.1 - 0.12 11.6 0.0 0.2 10.9 0.0 1.3 1 0 0 1 1 1 0 Phosphoenolpyruvate hydrolase-like DNA_pol_D_N PF18018.1 EGD96665.1 - 5.6e-37 126.7 0.0 8.7e-37 126.1 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase delta subunit OB-fold domain DNA_pol_E_B PF04042.16 EGD96665.1 - 1.9e-35 122.2 0.0 5.3e-35 120.7 0.0 1.7 2 0 0 2 2 2 1 DNA polymerase alpha/epsilon subunit B Acetyltransf_3 PF13302.7 EGD96666.1 - 2.9e-25 89.5 0.0 1e-24 87.8 0.0 1.8 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EGD96666.1 - 0.00073 19.5 0.1 0.14 12.2 0.0 2.4 2 0 0 2 2 2 2 FR47-like protein Acetyltransf_4 PF13420.7 EGD96666.1 - 0.01 15.9 0.3 0.043 14.0 0.0 2.1 3 0 0 3 3 3 0 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 EGD96666.1 - 0.011 15.4 2.4 0.79 9.4 0.7 3.2 3 0 0 3 3 3 0 Acetyltransferase (GNAT) domain Ribosomal_L38e PF01781.18 EGD96667.1 - 1.1e-31 108.7 1.9 1.3e-31 108.5 1.9 1.1 1 0 0 1 1 1 1 Ribosomal L38e protein family Ish1 PF10281.9 EGD96668.1 - 6.6e-07 29.5 0.1 1e-06 28.9 0.1 1.3 1 0 0 1 1 1 1 Putative stress-responsive nuclear envelope protein ABATE PF07336.11 EGD96668.1 - 0.032 14.9 0.9 0.044 14.5 0.9 1.3 1 1 0 1 1 1 0 Putative stress-induced transcription regulator SAP PF02037.27 EGD96668.1 - 0.076 12.8 0.1 1.4 8.8 0.0 2.1 2 0 0 2 2 2 0 SAP domain SAM_2 PF07647.17 EGD96668.1 - 0.14 12.3 0.1 0.22 11.7 0.1 1.3 1 1 0 1 1 1 0 SAM domain (Sterile alpha motif) NTF2 PF02136.20 EGD96669.1 - 7.3e-09 36.2 0.3 4.3e-07 30.5 0.3 2.2 1 1 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain Mtr2 PF10429.9 EGD96669.1 - 0.0026 17.7 0.1 0.0056 16.6 0.0 1.4 1 1 0 1 1 1 1 Nuclear pore RNA shuttling protein Mtr2 tRNA-synt_1g PF09334.11 EGD96670.1 - 3.8e-79 266.2 1.2 1.1e-67 228.5 0.1 2.9 1 1 1 2 2 2 2 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 EGD96670.1 - 1.1e-17 63.5 1.1 1.4e-11 43.4 0.0 3.7 2 2 2 4 4 4 3 tRNA synthetases class I (I, L, M and V) tRNA-synt_1e PF01406.19 EGD96670.1 - 0.0002 20.8 0.1 0.034 13.5 0.0 3.0 3 0 0 3 3 3 2 tRNA synthetases class I (C) catalytic domain PALP PF00291.25 EGD96671.1 - 6.6e-56 189.9 0.4 2.7e-53 181.3 0.1 2.6 1 1 1 2 2 2 2 Pyridoxal-phosphate dependent enzyme PPTA PF01239.22 EGD96672.1 - 2.9e-18 65.0 0.3 0.00022 20.9 0.0 3.7 3 0 0 3 3 3 3 Protein prenyltransferase alpha subunit repeat TPR_14 PF13428.6 EGD96672.1 - 0.34 11.9 2.9 0.56 11.2 0.7 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat GHMP_kinases_N PF00288.26 EGD96673.1 - 3.3e-16 59.3 0.5 2.9e-15 56.3 0.0 2.3 2 0 0 2 2 2 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 EGD96673.1 - 1.5e-09 38.1 0.0 3.6e-09 36.9 0.0 1.6 1 0 0 1 1 1 1 GHMP kinases C terminal GalKase_gal_bdg PF10509.9 EGD96673.1 - 0.0004 19.9 0.0 0.0008 18.9 0.0 1.5 1 0 0 1 1 1 1 Galactokinase galactose-binding signature AA_permease PF00324.21 EGD96674.1 - 6.3e-54 183.3 32.9 7.8e-54 183.0 32.9 1.1 1 0 0 1 1 1 1 Amino acid permease SLC12 PF03522.15 EGD96674.1 - 1.9e-22 79.9 0.0 8.2e-07 28.4 0.0 3.3 3 0 0 3 3 3 3 Solute carrier family 12 Aa_trans PF01490.18 EGD96675.1 - 3e-83 279.8 34.1 3.7e-83 279.5 34.1 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein TM_PBP2_N PF16296.5 EGD96675.1 - 0.069 13.3 0.2 0.24 11.5 0.0 2.0 2 0 0 2 2 2 0 N-terminal of TM subunit in PBP-dependent ABC transporters LSM PF01423.22 EGD96676.1 - 4.1e-19 68.0 0.0 5.1e-19 67.7 0.0 1.1 1 0 0 1 1 1 1 LSM domain Ribosomal_L5_C PF00673.21 EGD96677.1 - 3.3e-22 78.5 0.0 4.8e-22 77.9 0.0 1.3 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.19 EGD96677.1 - 2e-20 72.9 0.0 7.4e-20 71.0 0.0 2.0 2 0 0 2 2 2 1 Ribosomal protein L5 DUF4764 PF15961.5 EGD96678.1 - 0.24 10.1 3.4 0.27 9.9 3.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4764) TMEM52 PF14979.6 EGD96678.1 - 0.25 11.2 0.8 0.35 10.8 0.8 1.2 1 0 0 1 1 1 0 Transmembrane 52 CPSase_L_D2 PF02786.17 EGD96679.1 - 1.3e-80 269.8 0.1 2.1e-80 269.2 0.1 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain PYC_OADA PF02436.18 EGD96679.1 - 4e-70 235.6 0.0 6.4e-70 234.9 0.0 1.3 1 0 0 1 1 1 1 Conserved carboxylase domain Biotin_carb_N PF00289.22 EGD96679.1 - 1.2e-39 135.3 0.1 2.5e-39 134.2 0.1 1.6 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 EGD96679.1 - 1.2e-31 109.0 0.0 4e-31 107.3 0.0 1.9 2 0 0 2 2 2 1 Biotin carboxylase C-terminal domain HMGL-like PF00682.19 EGD96679.1 - 2.9e-23 82.8 0.0 5.9e-23 81.8 0.0 1.5 1 0 0 1 1 1 1 HMGL-like Biotin_lipoyl PF00364.22 EGD96679.1 - 4.3e-17 61.7 4.5 4.6e-17 61.6 2.9 1.9 2 0 0 2 2 2 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.6 EGD96679.1 - 5.6e-09 35.7 1.9 0.0001 22.1 0.1 3.2 2 1 1 3 3 3 2 Biotin-lipoyl like Dala_Dala_lig_C PF07478.13 EGD96679.1 - 8e-09 35.3 0.0 1.5e-08 34.4 0.0 1.4 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 EGD96679.1 - 6e-07 29.2 0.0 1.2e-06 28.2 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_3 PF02655.14 EGD96679.1 - 0.00011 22.3 0.0 0.00029 20.9 0.0 1.7 1 0 0 1 1 1 1 ATP-grasp domain RimK PF08443.11 EGD96679.1 - 0.00047 19.8 0.0 0.00098 18.8 0.0 1.5 1 0 0 1 1 1 1 RimK-like ATP-grasp domain HlyD_D23 PF16576.5 EGD96679.1 - 0.0016 17.7 0.2 0.1 11.8 0.1 2.5 1 1 1 2 2 2 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion HlyD_3 PF13437.6 EGD96679.1 - 0.019 15.7 0.1 7.6 7.3 0.1 3.1 3 0 0 3 3 3 0 HlyD family secretion protein ATP-grasp_4 PF13535.6 EGD96679.1 - 0.025 14.2 0.0 0.36 10.4 0.0 2.4 2 0 0 2 2 2 0 ATP-grasp domain DUF2118 PF09891.9 EGD96679.1 - 0.038 14.0 0.1 0.091 12.7 0.1 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2118) Clathrin PF00637.20 EGD96680.1 - 3.6e-189 620.2 31.0 7.1e-33 113.5 0.4 7.4 6 1 1 7 7 7 7 Region in Clathrin and VPS Clathrin_propel PF01394.20 EGD96680.1 - 5.2e-31 105.4 4.8 1.4e-05 25.1 0.0 6.6 6 0 0 6 6 6 5 Clathrin propeller repeat Clathrin_H_link PF13838.6 EGD96680.1 - 2.5e-29 100.9 1.7 6.8e-29 99.6 0.3 2.6 2 1 0 2 2 2 1 Clathrin-H-link Clathrin-link PF09268.10 EGD96680.1 - 0.0011 18.3 0.1 0.0025 17.1 0.1 1.7 1 0 0 1 1 1 1 Clathrin, heavy-chain linker TPR_14 PF13428.6 EGD96680.1 - 0.0024 18.6 4.3 1.1e+02 4.0 0.0 7.6 9 0 0 9 9 7 0 Tetratricopeptide repeat TPR_8 PF13181.6 EGD96680.1 - 0.035 14.3 4.1 2.9 8.4 0.0 5.2 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_7 PF13176.6 EGD96680.1 - 0.055 13.5 5.6 95 3.4 0.0 6.6 7 0 0 7 7 7 0 Tetratricopeptide repeat VapB_antitoxin PF09957.9 EGD96680.1 - 0.11 12.5 0.6 0.47 10.4 0.0 2.5 3 0 0 3 3 3 0 Bacterial antitoxin of type II TA system, VapB TPR_1 PF00515.28 EGD96680.1 - 0.18 11.7 0.8 32 4.6 0.0 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF1400 PF07176.11 EGD96680.1 - 1.1 9.5 4.6 10 6.4 0.0 4.3 5 1 1 6 6 6 0 Alpha/beta hydrolase of unknown function (DUF1400) TPR_19 PF14559.6 EGD96680.1 - 6 7.4 8.4 51 4.5 0.0 5.0 6 0 0 6 6 4 0 Tetratricopeptide repeat Transformer PF06495.11 EGD96681.1 - 0.22 11.6 1.8 0.24 11.5 1.8 1.1 1 0 0 1 1 1 0 Fruit fly transformer protein INSIG PF07281.12 EGD96682.1 - 3.3e-74 249.1 5.6 5.8e-74 248.3 5.6 1.4 1 0 0 1 1 1 1 Insulin-induced protein (INSIG) DEAD PF00270.29 EGD96684.1 - 1.6e-27 96.4 0.0 3e-13 49.9 0.0 2.9 2 1 1 3 3 3 2 DEAD/DEAH box helicase Helicase_C PF00271.31 EGD96684.1 - 6.5e-19 68.3 0.0 1.2e-18 67.5 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Fungal_trans_2 PF11951.8 EGD96685.1 - 3e-06 26.3 0.0 2.3e-05 23.4 0.0 2.2 2 1 0 2 2 2 1 Fungal specific transcription factor domain DUF639 PF04842.12 EGD96685.1 - 0.2 11.0 0.0 0.35 10.2 0.0 1.3 1 0 0 1 1 1 0 Plant protein of unknown function (DUF639) COesterase PF00135.28 EGD96687.1 - 1.5e-103 347.4 0.0 1.9e-103 347.1 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EGD96687.1 - 4.5e-05 23.4 0.0 0.00011 22.1 0.0 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EGD96687.1 - 0.0058 16.1 0.0 0.012 15.1 0.0 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family Pro_isomerase PF00160.21 EGD96688.1 - 9e-50 169.0 0.3 1.2e-49 168.6 0.3 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Ribosomal_S13 PF00416.22 EGD96689.1 - 1.7e-16 60.8 0.1 2.3e-14 53.9 0.1 2.0 1 1 0 1 1 1 1 Ribosomal protein S13/S18 WD40 PF00400.32 EGD96690.1 - 6.3e-18 64.8 19.3 4.1e-07 30.6 0.2 6.0 6 0 0 6 6 6 5 WD domain, G-beta repeat NLE PF08154.12 EGD96690.1 - 4e-17 62.5 0.1 7e-17 61.7 0.1 1.4 1 0 0 1 1 1 1 NLE (NUC135) domain Nup160 PF11715.8 EGD96690.1 - 0.007 15.1 2.1 0.051 12.2 0.7 2.4 2 1 1 3 3 3 1 Nucleoporin Nup120/160 Zw10 PF06248.13 EGD96691.1 - 5.6e-08 31.8 5.7 2.4e-07 29.7 5.5 1.9 1 1 0 1 1 1 1 Centromere/kinetochore Zw10 Dsl1_C PF11989.8 EGD96691.1 - 2e-06 27.7 0.1 4.4e-06 26.6 0.1 1.5 1 0 0 1 1 1 1 Retrograde transport protein Dsl1 C terminal IFT46_B_C PF12317.8 EGD96691.1 - 0.16 11.7 1.8 0.32 10.7 1.8 1.5 1 0 0 1 1 1 0 Intraflagellar transport complex B protein 46 C terminal ArAE_1_C PF11728.8 EGD96691.1 - 0.25 11.3 5.6 0.63 10.0 5.6 1.6 1 0 0 1 1 1 0 Putative aromatic acid exporter C-terminal domain Peptidase_M16_C PF05193.21 EGD96692.1 - 1e-16 61.5 0.0 3.2e-15 56.6 0.0 2.9 2 1 0 2 2 2 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 EGD96692.1 - 4e-08 33.3 0.0 1e-07 32.1 0.0 1.7 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) RQC PF09382.10 EGD96692.1 - 0.031 14.1 0.2 1 9.1 0.0 2.7 2 0 0 2 2 2 0 RQC domain SMBP PF16785.5 EGD96692.1 - 0.21 11.8 1.0 0.64 10.3 1.0 1.8 1 0 0 1 1 1 0 Small metal-binding protein RRN3 PF05327.11 EGD96692.1 - 2.3 6.7 6.7 3.9 5.9 6.7 1.4 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Ank_2 PF12796.7 EGD96693.1 - 5.9e-50 167.8 0.1 9.2e-16 58.2 0.0 6.2 5 2 1 6 6 6 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EGD96693.1 - 8.9e-44 147.3 0.6 6.9e-11 42.4 0.1 8.4 4 2 5 9 9 9 8 Ankyrin repeats (many copies) Ank_3 PF13606.6 EGD96693.1 - 5.7e-36 118.4 0.2 0.0027 18.1 0.0 11.9 11 0 0 11 11 11 8 Ankyrin repeat Ank PF00023.30 EGD96693.1 - 2.1e-25 88.0 5.0 0.074 13.5 0.1 11.0 13 0 0 13 13 13 6 Ankyrin repeat Ank_5 PF13857.6 EGD96693.1 - 3.2e-25 87.8 0.7 1e-05 25.7 0.0 8.1 4 2 4 8 8 8 7 Ankyrin repeats (many copies) NACHT PF05729.12 EGD96693.1 - 0.079 12.9 0.0 0.17 11.8 0.0 1.5 1 0 0 1 1 1 0 NACHT domain Hydrolase_4 PF12146.8 EGD96695.1 - 6.8e-09 35.3 0.0 9.4e-09 34.9 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EGD96695.1 - 9.7e-09 36.1 0.5 1.6e-08 35.4 0.5 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EGD96695.1 - 0.00022 20.9 0.3 0.00035 20.3 0.3 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EGD96695.1 - 0.016 14.7 0.1 3.5 7.0 0.1 2.2 2 0 0 2 2 2 0 Prolyl oligopeptidase family Fungal_trans PF04082.18 EGD96696.1 - 9.4e-18 64.2 0.2 1.9e-17 63.2 0.2 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EGD96696.1 - 7.8e-09 35.5 11.9 1.6e-08 34.6 11.9 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MFS_1 PF07690.16 EGD96697.1 - 3.9e-41 141.1 55.8 2.4e-40 138.6 51.2 2.8 2 1 0 2 2 2 1 Major Facilitator Superfamily Cu-oxidase_3 PF07732.15 EGD96698.1 - 4.8e-42 142.7 1.6 4.1e-41 139.7 0.3 2.3 2 0 0 2 2 2 1 Multicopper oxidase Cu-oxidase_2 PF07731.14 EGD96698.1 - 1.2e-23 83.3 6.3 3.1e-17 62.6 0.9 3.1 2 1 0 2 2 2 2 Multicopper oxidase Cu-oxidase PF00394.22 EGD96698.1 - 5.1e-15 55.9 0.0 2.4e-13 50.5 0.0 2.7 2 1 0 2 2 2 1 Multicopper oxidase Zn_clus PF00172.18 EGD96699.1 - 2.1e-06 27.7 9.8 2.1e-06 27.7 9.8 2.1 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain EthD PF07110.11 EGD96700.1 - 4.3e-19 69.5 0.2 6.7e-19 68.8 0.2 1.3 1 0 0 1 1 1 1 EthD domain SAT PF16073.5 EGD96701.1 - 3.8e-68 229.8 0.2 3.8e-68 229.8 0.2 2.4 2 0 0 2 2 2 1 Starter unit:ACP transacylase in aflatoxin biosynthesis ketoacyl-synt PF00109.26 EGD96701.1 - 9.5e-66 221.9 0.1 7.1e-64 215.8 0.1 2.4 1 1 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.21 EGD96701.1 - 1.1e-38 133.5 0.0 2.4e-38 132.4 0.0 1.5 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 EGD96701.1 - 8.3e-33 112.9 0.6 3.7e-32 110.8 0.2 2.3 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain Thioesterase PF00975.20 EGD96701.1 - 9.1e-26 91.4 0.1 1.1e-24 87.8 0.0 2.9 3 1 0 3 3 3 1 Thioesterase domain PP-binding PF00550.25 EGD96701.1 - 3.4e-18 65.8 4.1 1.7e-10 41.1 0.6 2.8 2 0 0 2 2 2 2 Phosphopantetheine attachment site PS-DH PF14765.6 EGD96701.1 - 8.5e-14 51.5 0.0 1.4e-13 50.8 0.0 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase Abhydrolase_6 PF12697.7 EGD96701.1 - 6.7e-09 36.7 0.4 8e-05 23.3 0.0 3.0 2 0 0 2 2 2 2 Alpha/beta hydrolase family Thiolase_N PF00108.23 EGD96701.1 - 5.7e-06 25.9 0.0 1.3e-05 24.7 0.0 1.6 1 0 0 1 1 1 1 Thiolase, N-terminal domain KAsynt_C_assoc PF16197.5 EGD96701.1 - 0.00038 20.9 0.0 0.001 19.5 0.0 1.7 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Hydrolase_4 PF12146.8 EGD96701.1 - 0.047 12.9 0.1 1.9 7.7 0.0 2.4 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Methyltransf_2 PF00891.18 EGD96702.1 - 1.7e-25 89.6 0.0 2.5e-25 89.0 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_25 PF13649.6 EGD96702.1 - 0.0025 18.5 0.0 0.0052 17.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EGD96702.1 - 0.0037 18.0 0.0 0.0063 17.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Peptidase_M48_N PF16491.5 EGD96703.1 - 9.2e-67 224.5 8.9 9.2e-67 224.5 8.9 1.6 2 0 0 2 2 2 1 CAAX prenyl protease N-terminal, five membrane helices Peptidase_M48 PF01435.18 EGD96703.1 - 1.7e-44 152.0 0.8 2.1e-44 151.7 0.0 1.5 2 0 0 2 2 2 1 Peptidase family M48 DUF4538 PF15061.6 EGD96703.1 - 0.0093 15.7 1.1 0.027 14.2 1.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4538) Peptidase_M56 PF05569.11 EGD96703.1 - 0.025 13.8 1.8 0.12 11.6 0.5 2.3 2 1 0 2 2 2 0 BlaR1 peptidase M56 RNA_polI_A14 PF08203.11 EGD96704.1 - 0.045 14.5 0.1 0.63 10.8 0.0 2.3 2 0 0 2 2 2 0 Yeast RNA polymerase I subunit RPA14 Peptidase_S49_N PF08496.10 EGD96704.1 - 3.1 7.8 7.6 2.7 8.0 6.5 1.5 2 0 0 2 2 2 0 Peptidase family S49 N-terminal Ribosomal_L34 PF00468.17 EGD96705.1 - 4.6e-16 58.5 9.6 7.5e-16 57.8 9.6 1.4 1 0 0 1 1 1 1 Ribosomal protein L34 eIF2_C PF09173.11 EGD96706.1 - 3e-34 117.1 0.2 7.2e-34 115.9 0.2 1.7 1 0 0 1 1 1 1 Initiation factor eIF2 gamma, C terminal GTP_EFTU PF00009.27 EGD96706.1 - 4.7e-23 81.7 0.2 3.4e-22 78.9 0.2 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 EGD96706.1 - 8.7e-12 45.3 0.2 1.9e-11 44.2 0.2 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 RsgA_GTPase PF03193.16 EGD96706.1 - 0.0021 18.0 0.1 0.023 14.6 0.0 2.1 2 0 0 2 2 2 1 RsgA GTPase MMR_HSR1 PF01926.23 EGD96706.1 - 0.0061 16.6 0.0 0.012 15.7 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase WD40 PF00400.32 EGD96707.1 - 3.9e-09 37.0 0.0 3.7 8.6 0.0 5.5 5 0 0 5 5 5 3 WD domain, G-beta repeat Nucleoporin_N PF08801.11 EGD96707.1 - 0.0027 16.5 0.1 1.8 7.2 0.0 2.4 2 1 0 2 2 2 2 Nup133 N terminal like CW_7 PF08230.11 EGD96707.1 - 0.021 14.6 0.3 0.044 13.5 0.3 1.4 1 0 0 1 1 1 0 CW_7 repeat Myb_DNA-bind_6 PF13921.6 EGD96708.1 - 6.6e-17 61.5 0.1 6.6e-17 61.5 0.1 2.4 3 0 0 3 3 3 1 Myb-like DNA-binding domain HSA PF07529.13 EGD96708.1 - 1e-13 51.4 0.2 1e-13 51.4 0.2 3.3 3 0 0 3 3 3 1 HSA Myb_DNA-binding PF00249.31 EGD96708.1 - 0.00021 21.4 0.4 0.00057 20.0 0.4 1.8 1 0 0 1 1 1 1 Myb-like DNA-binding domain G-patch_2 PF12656.7 EGD96709.1 - 1.3e-24 86.0 0.2 4.9e-24 84.2 0.2 2.1 1 0 0 1 1 1 1 G-patch domain G-patch PF01585.23 EGD96709.1 - 0.00026 20.8 1.1 0.00071 19.4 0.5 2.1 2 0 0 2 2 2 1 G-patch domain WD40 PF00400.32 EGD96710.1 - 4.9e-55 182.3 15.7 1e-05 26.2 0.0 14.2 13 3 0 13 13 13 9 WD domain, G-beta repeat Utp13 PF08625.11 EGD96710.1 - 2.9e-48 163.4 0.2 4.6e-48 162.7 0.2 1.3 1 0 0 1 1 1 1 Utp13 specific WD40 associated domain ANAPC4_WD40 PF12894.7 EGD96710.1 - 1.8e-13 50.6 0.7 1.9 8.8 0.1 8.3 5 1 3 9 9 9 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EGD96710.1 - 1.4e-05 23.9 7.1 0.77 8.3 0.7 5.2 3 2 2 5 5 5 3 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 EGD96710.1 - 0.0016 17.5 3.6 6.8 5.5 0.0 5.3 3 2 3 6 6 6 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nucleoporin_N PF08801.11 EGD96710.1 - 0.002 16.9 4.4 1.8 7.2 0.1 4.6 5 1 2 7 7 7 2 Nup133 N terminal like MMS1_N PF10433.9 EGD96710.1 - 0.014 14.1 0.0 0.11 11.1 0.0 2.3 1 1 0 2 2 2 0 Mono-functional DNA-alkylating methyl methanesulfonate N-term DUF3086 PF11285.8 EGD96711.1 - 0.18 10.9 0.0 2 7.4 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3086) UCH PF00443.29 EGD96712.1 - 1.1e-21 77.5 0.1 3.4e-21 75.9 0.0 1.7 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 EGD96712.1 - 4.5e-12 46.1 0.3 7.8e-12 45.4 0.3 1.4 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein UCH_1 PF13423.6 EGD96712.1 - 0.0056 16.3 0.0 0.018 14.7 0.0 2.0 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase TLD PF07534.16 EGD96713.1 - 1.3e-10 41.6 0.0 2.5e-10 40.7 0.0 1.4 1 0 0 1 1 1 1 TLD MF_alpha_N PF05436.11 EGD96714.1 - 0.021 14.7 0.4 0.043 13.7 0.4 1.6 1 0 0 1 1 1 0 Mating factor alpha precursor N-terminus Peptidase_C97 PF05903.14 EGD96714.1 - 0.051 13.4 0.1 0.075 12.9 0.1 1.3 1 0 0 1 1 1 0 PPPDE putative peptidase domain Arrestin_N PF00339.29 EGD96714.1 - 0.081 13.0 1.1 0.12 12.4 1.1 1.3 1 0 0 1 1 1 0 Arrestin (or S-antigen), N-terminal domain LRRC37AB_C PF14914.6 EGD96714.1 - 0.23 11.4 2.6 0.4 10.6 2.6 1.4 1 0 0 1 1 1 0 LRRC37A/B like protein 1 C-terminal domain Proteasome PF00227.26 EGD96715.1 - 1.7e-29 102.7 0.0 1.9e-29 102.5 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit WD40 PF00400.32 EGD96716.1 - 8.2e-20 70.8 12.0 2.5e-05 24.9 0.0 5.9 5 0 0 5 5 5 4 WD domain, G-beta repeat Nup160 PF11715.8 EGD96716.1 - 9.6e-05 21.2 3.0 0.16 10.6 0.0 3.8 1 1 4 5 5 5 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 EGD96716.1 - 0.0016 18.7 0.0 0.021 15.1 0.0 2.7 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EGD96716.1 - 0.0089 15.4 0.0 0.016 14.5 0.0 1.4 1 0 0 1 1 1 1 WD40-like domain Nha1_C PF08619.10 EGD96716.1 - 2.1 7.4 12.3 4.6 6.3 12.3 1.5 1 0 0 1 1 1 0 Alkali metal cation/H+ antiporter Nha1 C terminus zf-C3HC4 PF00097.25 EGD96717.1 - 7.1e-09 35.4 7.7 7.1e-09 35.4 7.7 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EGD96717.1 - 1.6e-08 34.7 8.4 1.6e-08 34.7 8.4 2.3 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_3 PF13920.6 EGD96717.1 - 2.8e-08 33.5 5.5 2.8e-08 33.5 5.5 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EGD96717.1 - 3.3e-08 33.2 8.8 3.3e-08 33.2 8.8 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EGD96717.1 - 3e-07 30.5 10.6 3e-07 30.5 10.6 2.1 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.6 EGD96717.1 - 1.7e-06 27.9 9.1 1.7e-06 27.9 9.1 2.1 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_5 PF14634.6 EGD96717.1 - 4.5e-06 26.5 7.0 4.5e-06 26.5 7.0 2.4 2 1 0 2 2 2 1 zinc-RING finger domain Prok-RING_4 PF14447.6 EGD96717.1 - 0.0018 18.1 6.7 0.0018 18.1 6.7 2.6 2 1 1 3 3 3 1 Prokaryotic RING finger family 4 zf-rbx1 PF12678.7 EGD96717.1 - 0.023 15.0 7.9 0.023 15.0 7.9 2.2 2 1 0 2 2 2 0 RING-H2 zinc finger domain zf-RING_4 PF14570.6 EGD96717.1 - 0.026 14.3 3.5 0.026 14.3 3.5 2.7 2 1 0 2 2 2 0 RING/Ubox like zinc-binding domain DZR PF12773.7 EGD96717.1 - 0.074 13.1 14.6 2 8.5 0.2 3.3 2 1 1 3 3 3 0 Double zinc ribbon zf-RING_11 PF17123.5 EGD96717.1 - 0.32 10.8 4.0 1.3 8.8 4.0 2.1 1 0 0 1 1 1 0 RING-like zinc finger zf-RING_10 PF16685.5 EGD96717.1 - 0.76 10.0 5.7 1.6 8.9 5.7 1.5 1 0 0 1 1 1 0 zinc RING finger of MSL2 zf-ANAPC11 PF12861.7 EGD96717.1 - 0.9 9.6 9.7 0.061 13.4 4.1 2.0 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger CDC45 PF02724.14 EGD96717.1 - 6 5.0 7.3 8.8 4.5 7.3 1.2 1 0 0 1 1 1 0 CDC45-like protein CHCH PF06747.13 EGD96719.1 - 1.6e-05 24.9 4.2 3.3e-05 23.9 4.0 1.7 1 1 1 2 2 2 1 CHCH domain MTCP1 PF08991.10 EGD96719.1 - 0.00044 20.4 1.4 0.0006 20.0 1.4 1.2 1 0 0 1 1 1 1 Mature-T-Cell Proliferation I type Pet191_N PF10203.9 EGD96719.1 - 0.044 14.1 5.2 0.082 13.2 4.3 1.8 1 1 0 1 1 1 0 Cytochrome c oxidase assembly protein PET191 COX17 PF05051.13 EGD96719.1 - 0.061 13.7 2.6 0.42 11.0 1.4 2.1 1 1 1 2 2 2 0 Cytochrome C oxidase copper chaperone (COX17) UPF0203 PF05254.12 EGD96719.1 - 0.081 13.2 3.4 0.14 12.5 3.4 1.6 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0203) NatB_MDM20 PF09797.9 EGD96720.1 - 9.2e-102 340.8 1.0 1.4e-101 340.2 1.0 1.3 1 0 0 1 1 1 1 N-acetyltransferase B complex (NatB) non catalytic subunit TPR_19 PF14559.6 EGD96720.1 - 3.4e-06 27.5 7.9 0.0058 17.1 0.2 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 EGD96720.1 - 2.5 9.1 10.8 72 4.6 0.2 5.7 6 0 0 6 6 6 0 Tetratricopeptide repeat Proteasome PF00227.26 EGD96721.1 - 5.6e-42 143.4 0.0 6.5e-42 143.2 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit TUG-UBL1 PF11470.8 EGD96722.1 - 9.8e-25 86.6 1.1 2.9e-24 85.1 0.1 2.3 2 0 0 2 2 2 1 TUG ubiquitin-like domain UBX PF00789.20 EGD96722.1 - 4.8e-06 26.7 0.1 4.6e-05 23.5 0.0 2.7 3 0 0 3 3 3 1 UBX domain RBD PF02196.15 EGD96722.1 - 0.012 15.7 0.0 0.056 13.5 0.0 2.0 2 0 0 2 2 2 0 Raf-like Ras-binding domain Ribosomal_L36e PF01158.18 EGD96723.1 - 5.1e-38 129.2 7.1 5.7e-38 129.1 7.1 1.0 1 0 0 1 1 1 1 Ribosomal protein L36e HTH_38 PF13936.6 EGD96723.1 - 0.0095 15.7 1.6 0.22 11.3 0.1 2.6 2 1 0 2 2 2 1 Helix-turn-helix domain PBS_linker_poly PF00427.21 EGD96723.1 - 0.04 14.0 0.4 0.044 13.8 0.4 1.1 1 0 0 1 1 1 0 Phycobilisome Linker polypeptide LemA PF04011.12 EGD96723.1 - 0.13 12.1 0.3 0.16 11.8 0.3 1.2 1 0 0 1 1 1 0 LemA family MRP-L28 PF09812.9 EGD96723.1 - 0.13 12.4 2.6 0.15 12.2 2.6 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal protein L28 DUF2207 PF09972.9 EGD96723.1 - 0.13 11.0 0.1 0.14 10.9 0.1 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF4239 PF14023.6 EGD96723.1 - 0.14 11.9 0.1 0.18 11.5 0.1 1.2 1 1 0 1 1 1 0 Protein of unknown function (DUF4239) HATPase_c PF02518.26 EGD96724.1 - 5.9e-19 68.6 0.0 2e-18 66.9 0.0 1.9 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 EGD96724.1 - 2e-14 53.7 0.5 6.7e-09 35.9 0.1 3.4 2 1 0 2 2 2 2 Response regulator receiver domain HisKA PF00512.25 EGD96724.1 - 4.5e-05 23.4 0.1 0.0002 21.3 0.1 2.1 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HATPase_c_3 PF13589.6 EGD96724.1 - 0.055 13.3 0.0 0.17 11.7 0.0 1.8 2 0 0 2 2 2 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase M20_dimer PF07687.14 EGD96725.1 - 2.6e-21 75.6 0.0 6.8e-21 74.2 0.0 1.7 2 0 0 2 2 2 1 Peptidase dimerisation domain Peptidase_M20 PF01546.28 EGD96725.1 - 2.2e-15 57.0 0.1 8e-14 51.8 0.1 2.3 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 Peptidase_M42 PF05343.14 EGD96725.1 - 0.00014 21.0 0.0 0.0013 17.8 0.0 2.4 2 0 0 2 2 2 1 M42 glutamyl aminopeptidase Peptidase_M28 PF04389.17 EGD96725.1 - 0.025 14.2 0.0 0.047 13.4 0.0 1.4 1 0 0 1 1 1 0 Peptidase family M28 DUF373 PF04123.13 EGD96725.1 - 0.03 13.8 0.3 0.049 13.1 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF373) Peptidase_C14 PF00656.22 EGD96725.1 - 0.16 11.9 0.0 3.4 7.5 0.0 2.1 2 0 0 2 2 2 0 Caspase domain Glyco_hydro_47 PF01532.20 EGD96726.1 - 3e-164 547.3 0.0 3.6e-164 547.0 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 AAA PF00004.29 EGD96727.1 - 7.2e-43 146.2 0.0 1.2e-42 145.4 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 EGD96727.1 - 3.4e-11 42.9 0.0 9.5e-11 41.5 0.0 1.8 2 0 0 2 2 1 1 Proteasomal ATPase OB C-terminal domain AAA_lid_3 PF17862.1 EGD96727.1 - 1.6e-10 40.6 0.1 3e-10 39.7 0.1 1.5 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 EGD96727.1 - 2.8e-07 31.1 0.0 0.00012 22.5 0.0 2.7 2 1 1 3 3 3 1 AAA ATPase domain AAA_5 PF07728.14 EGD96727.1 - 1.8e-06 28.0 0.0 4.3e-05 23.5 0.0 2.7 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 EGD96727.1 - 2.5e-06 27.7 0.0 8e-06 26.1 0.0 1.9 2 0 0 2 2 1 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 EGD96727.1 - 6.9e-06 25.9 0.0 1.6e-05 24.7 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EGD96727.1 - 0.00019 21.8 0.0 0.0031 17.8 0.0 2.4 1 1 0 1 1 1 1 AAA domain DUF815 PF05673.13 EGD96727.1 - 0.00046 19.4 0.0 0.00096 18.4 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_18 PF13238.6 EGD96727.1 - 0.00051 20.6 0.1 0.0033 18.0 0.0 2.3 2 1 0 2 2 2 1 AAA domain AAA_7 PF12775.7 EGD96727.1 - 0.00056 19.5 0.0 0.0011 18.5 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region TIP49 PF06068.13 EGD96727.1 - 0.0019 17.5 0.0 0.0037 16.5 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_33 PF13671.6 EGD96727.1 - 0.0039 17.3 0.0 0.0095 16.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain Prot_ATP_OB_N PF17758.1 EGD96727.1 - 0.0041 16.7 0.0 0.012 15.2 0.0 1.7 1 0 0 1 1 1 1 Proteasomal ATPase OB N-terminal domain Mg_chelatase PF01078.21 EGD96727.1 - 0.0048 16.3 0.0 0.0093 15.4 0.0 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI TsaE PF02367.17 EGD96727.1 - 0.0052 16.8 0.0 0.011 15.7 0.0 1.5 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_14 PF13173.6 EGD96727.1 - 0.0073 16.3 0.0 0.019 15.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 EGD96727.1 - 0.0074 16.0 0.0 0.015 15.1 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein Sigma54_activat PF00158.26 EGD96727.1 - 0.0091 15.7 0.0 0.03 14.0 0.0 1.9 1 1 0 1 1 1 1 Sigma-54 interaction domain AAA_3 PF07726.11 EGD96727.1 - 0.0093 15.8 0.0 0.022 14.6 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 EGD96727.1 - 0.012 16.0 0.0 0.023 15.1 0.0 1.5 1 0 0 1 1 1 0 RNA helicase ATPase PF06745.13 EGD96727.1 - 0.032 13.6 0.0 0.13 11.6 0.0 2.0 2 0 0 2 2 2 0 KaiC AAA_24 PF13479.6 EGD96727.1 - 0.034 13.9 0.0 0.087 12.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 EGD96727.1 - 0.073 13.0 0.1 0.19 11.7 0.0 1.7 2 0 0 2 2 2 0 NACHT domain PhoH PF02562.16 EGD96727.1 - 0.075 12.5 0.0 0.13 11.7 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein AAA_30 PF13604.6 EGD96727.1 - 0.097 12.4 0.0 0.27 10.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain Parvo_NS1 PF01057.17 EGD96727.1 - 0.1 11.7 0.0 0.16 11.0 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_25 PF13481.6 EGD96727.1 - 0.1 12.1 0.0 0.23 11.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 EGD96727.1 - 0.11 11.7 0.0 0.24 10.6 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin AAA_28 PF13521.6 EGD96727.1 - 0.11 12.7 0.0 0.21 11.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.6 EGD96727.1 - 0.13 12.0 0.1 0.33 10.7 0.0 1.7 2 0 0 2 2 2 0 AAA domain Cation_ATPase_C PF00689.21 EGD96728.1 - 1.8e-43 148.4 3.9 1.8e-43 148.4 3.9 2.7 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 EGD96728.1 - 1.5e-38 132.1 4.0 9e-38 129.6 1.4 3.0 3 0 0 3 3 3 1 E1-E2 ATPase Hydrolase PF00702.26 EGD96728.1 - 2.4e-19 70.5 0.0 1.1e-07 32.4 0.0 3.3 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EGD96728.1 - 5.7e-18 64.8 0.0 1.2e-17 63.8 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 EGD96728.1 - 2.3e-11 43.2 0.0 4.9e-11 42.2 0.0 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 EGD96728.1 - 0.00079 19.2 0.2 0.0019 18.0 0.2 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 EGD96728.1 - 0.019 15.4 0.0 4.5 7.6 0.0 2.4 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase DUF2157 PF09925.9 EGD96728.1 - 3 7.6 6.7 11 5.8 0.9 3.3 3 0 0 3 3 3 0 Predicted membrane protein (DUF2157) DUF5543 PF17697.1 EGD96729.1 - 0.0023 18.2 0.4 0.0029 17.9 0.4 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF5543) Enolase_C PF00113.22 EGD96730.1 - 1.4e-153 510.4 0.0 1.8e-153 510.0 0.0 1.1 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.16 EGD96730.1 - 4.4e-57 191.9 0.2 7.5e-57 191.1 0.2 1.4 1 0 0 1 1 1 1 Enolase, N-terminal domain MR_MLE_C PF13378.6 EGD96730.1 - 2.1e-05 24.2 0.0 3.8e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 Enolase C-terminal domain-like VSP PF03302.13 EGD96730.1 - 0.13 11.1 0.1 0.19 10.5 0.1 1.2 1 0 0 1 1 1 0 Giardia variant-specific surface protein eIF3_subunit PF08597.10 EGD96731.1 - 4e-67 226.7 28.6 4.6e-67 226.5 28.6 1.0 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit DUF572 PF04502.13 EGD96731.1 - 0.068 12.8 20.8 0.089 12.4 20.8 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) DUF5384 PF17358.2 EGD96731.1 - 0.093 12.8 25.5 0.029 14.4 18.1 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5384) Rrn6 PF10214.9 EGD96731.1 - 0.74 8.2 8.6 0.99 7.8 8.6 1.2 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor GREB1 PF15782.5 EGD96731.1 - 1.6 5.7 7.0 1.7 5.7 7.0 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer 14-3-3 PF00244.20 EGD96732.1 - 6.4e-107 356.1 3.6 8e-107 355.8 3.6 1.1 1 0 0 1 1 1 1 14-3-3 protein DUF4164 PF13747.6 EGD96732.1 - 0.11 12.7 2.0 0.41 11.0 0.3 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4164) Peptidase_C98 PF15499.6 EGD96732.1 - 0.16 11.4 0.1 0.24 10.8 0.1 1.4 1 0 0 1 1 1 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase Ima1_N PF09779.9 EGD96732.1 - 0.29 12.0 2.8 2.1 9.2 0.0 3.2 4 0 0 4 4 4 0 Ima1 N-terminal domain adh_short PF00106.25 EGD96733.1 - 1.4e-19 70.3 0.0 7.6e-17 61.4 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EGD96733.1 - 5.8e-09 35.8 0.0 3.3e-08 33.4 0.0 1.9 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EGD96733.1 - 0.00048 20.1 0.0 0.00075 19.5 0.0 1.3 1 0 0 1 1 1 1 KR domain E1-E2_ATPase PF00122.20 EGD96734.1 - 4.9e-49 166.3 2.3 4.9e-49 166.3 2.3 3.1 3 0 0 3 3 3 2 E1-E2 ATPase Cation_ATPase_C PF00689.21 EGD96734.1 - 1.8e-46 158.2 7.5 1.8e-46 158.2 7.5 1.9 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 EGD96734.1 - 1.9e-22 80.6 0.5 8.1e-22 78.5 0.5 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EGD96734.1 - 6.7e-20 70.5 0.1 2.8e-19 68.6 0.0 2.2 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Cation_ATPase PF13246.6 EGD96734.1 - 3.1e-16 59.2 0.0 6.3e-16 58.2 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 EGD96734.1 - 3.5e-08 33.5 1.5 6.7e-06 26.0 1.0 2.4 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD PF12710.7 EGD96734.1 - 1.1e-06 29.2 0.0 3.9e-06 27.4 0.0 2.0 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Peptidase_S8 PF00082.22 EGD96735.1 - 2.9e-30 105.6 17.3 2.9e-30 105.6 17.3 1.6 2 1 0 2 2 2 1 Subtilase family Inhibitor_I9 PF05922.16 EGD96735.1 - 5.4e-16 59.0 0.5 9.1e-16 58.3 0.5 1.4 1 0 0 1 1 1 1 Peptidase inhibitor I9 MBOAT_2 PF13813.6 EGD96737.1 - 3.4e-17 62.5 4.6 8.4e-17 61.2 4.6 1.7 1 0 0 1 1 1 1 Membrane bound O-acyl transferase family FAM76 PF16046.5 EGD96738.1 - 1.4 8.2 3.2 1.8 7.9 3.2 1.1 1 0 0 1 1 1 0 FAM76 protein Macoilin PF09726.9 EGD96738.1 - 10 4.6 6.7 12 4.3 6.7 1.0 1 0 0 1 1 1 0 Macoilin family DnaJ PF00226.31 EGD96739.1 - 2.1e-19 69.4 3.5 3.6e-19 68.6 3.5 1.4 1 0 0 1 1 1 1 DnaJ domain DUF456 PF04306.13 EGD96739.1 - 0.00099 19.4 2.3 0.0015 18.8 2.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF456) DUF2076 PF09849.9 EGD96739.1 - 0.0016 18.5 0.1 0.0023 18.0 0.1 1.3 1 1 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2076) DUF460 PF04312.13 EGD96739.1 - 0.13 12.0 0.4 0.21 11.3 0.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF460) Bacteriocin_IIc PF10439.9 EGD96739.1 - 0.9 9.7 7.9 1.6 8.9 7.9 1.4 1 0 0 1 1 1 0 Bacteriocin class II with double-glycine leader peptide MFS_1 PF07690.16 EGD96741.1 - 7.5e-40 136.9 50.1 2.1e-39 135.5 50.1 1.7 1 1 0 1 1 1 1 Major Facilitator Superfamily TadZ_N PF16968.5 EGD96741.1 - 0.8 9.4 4.1 0.42 10.3 1.3 1.9 2 0 0 2 2 2 0 Pilus assembly protein TadZ N-terminal PMM PF03332.13 EGD96742.1 - 2.8e-103 344.4 0.1 3.3e-103 344.2 0.1 1.0 1 0 0 1 1 1 1 Eukaryotic phosphomannomutase Hydrolase_3 PF08282.12 EGD96742.1 - 3e-05 23.9 0.0 0.00019 21.3 0.0 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase TMPIT PF07851.13 EGD96742.1 - 0.037 13.3 0.1 0.05 12.8 0.1 1.1 1 0 0 1 1 1 0 TMPIT-like protein DUF1640 PF07798.11 EGD96743.1 - 1.4e-56 191.3 6.5 1.7e-56 191.1 6.5 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1640) BST2 PF16716.5 EGD96743.1 - 4 8.1 5.8 1.3 9.7 0.6 2.3 2 1 1 3 3 3 0 Bone marrow stromal antigen 2 Trypsin_2 PF13365.6 EGD96744.1 - 6.3e-27 95.3 0.0 9.2e-27 94.8 0.0 1.2 1 0 0 1 1 1 1 Trypsin-like peptidase domain Trypsin PF00089.26 EGD96744.1 - 1.3e-05 25.1 0.0 2.6e-05 24.1 0.0 1.4 1 1 0 1 1 1 1 Trypsin Peptidase_S32 PF05579.13 EGD96744.1 - 0.053 12.7 0.0 0.88 8.7 0.0 2.0 2 0 0 2 2 2 0 Equine arteritis virus serine endopeptidase S32 Eisosome1 PF12757.7 EGD96745.1 - 4e-28 98.2 3.3 4e-28 98.2 3.3 2.5 3 0 0 3 3 3 1 Eisosome protein 1 CAP PF00188.26 EGD96745.1 - 0.041 14.7 0.3 0.15 12.9 0.3 2.0 1 0 0 1 1 1 0 Cysteine-rich secretory protein family MFS_1 PF07690.16 EGD96746.1 - 2.5e-16 59.5 42.4 8.4e-15 54.5 42.6 2.1 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EGD96746.1 - 0.00019 20.5 8.0 0.00019 20.5 8.0 2.8 2 1 0 2 2 2 1 Sugar (and other) transporter HlyIII PF03006.20 EGD96746.1 - 0.0015 18.3 10.3 0.0062 16.3 0.1 3.3 1 1 1 3 3 3 2 Haemolysin-III related LapA_dom PF06305.11 EGD96746.1 - 0.12 12.2 1.6 1.3 8.9 0.0 3.2 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain TRIQK PF15168.6 EGD96746.1 - 0.73 9.8 4.5 0.68 9.9 0.2 2.8 3 0 0 3 3 3 0 Triple QxxK/R motif-containing protein family Pkinase PF00069.25 EGD96747.1 - 3.1e-66 223.4 0.0 5e-66 222.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD96747.1 - 1.6e-41 142.3 0.0 2.4e-41 141.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EGD96747.1 - 1.6e-08 34.2 0.0 2.4e-07 30.4 0.0 2.1 2 0 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 EGD96747.1 - 9.9e-06 24.7 0.0 9.9e-06 24.7 0.0 2.1 2 0 0 2 2 2 1 Haspin like kinase domain PRKG1_interact PF15898.5 EGD96747.1 - 0.018 15.9 2.9 0.059 14.3 2.9 1.8 1 0 0 1 1 1 0 cGMP-dependent protein kinase interacting domain Kdo PF06293.14 EGD96747.1 - 0.04 13.3 0.0 0.04 13.3 0.0 2.1 2 1 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Ferlin_C PF16165.5 EGD96747.1 - 0.27 11.2 0.5 0.48 10.4 0.5 1.3 1 0 0 1 1 1 0 Ferlin C-terminus APH PF01636.23 EGD96747.1 - 0.9 9.4 6.9 1.2 9.0 0.1 2.9 2 1 1 3 3 3 0 Phosphotransferase enzyme family RIO1 PF01163.22 EGD96747.1 - 2.8 7.5 4.3 1.5 8.4 0.0 2.2 2 0 0 2 2 2 0 RIO1 family Prenyltrans PF00432.21 EGD96748.1 - 5.5e-31 106.0 13.2 7.1e-08 32.1 0.1 5.9 6 0 0 6 6 6 5 Prenyltransferase and squalene oxidase repeat SQHop_cyclase_C PF13243.6 EGD96748.1 - 0.0017 17.5 0.0 0.0099 15.0 0.0 2.2 1 1 0 1 1 1 1 Squalene-hopene cyclase C-terminal domain SQHop_cyclase_N PF13249.6 EGD96748.1 - 0.14 11.2 0.0 8.2 5.4 0.0 3.2 4 1 0 4 4 4 0 Squalene-hopene cyclase N-terminal domain Ilm1 PF10311.9 EGD96749.1 - 1.9e-60 203.3 0.3 2.3e-60 203.0 0.3 1.1 1 0 0 1 1 1 1 Increased loss of mitochondrial DNA protein 1 DUF5357 PF17310.2 EGD96749.1 - 0.96 7.9 5.3 11 4.4 5.3 2.1 1 1 0 1 1 1 0 Family of unknown function (DUF5357) CFEM PF05730.11 EGD96751.1 - 7.2e-14 51.6 14.1 1.2e-13 50.9 14.1 1.4 1 0 0 1 1 1 1 CFEM domain MFS_1 PF07690.16 EGD96752.1 - 3.4e-18 65.7 31.7 9.3e-12 44.5 6.5 2.8 1 1 2 3 3 3 2 Major Facilitator Superfamily MFS_1 PF07690.16 EGD96753.1 - 3.7e-10 39.3 41.5 3.7e-10 39.3 41.5 2.2 1 1 2 3 3 3 1 Major Facilitator Superfamily UNC-93 PF05978.16 EGD96753.1 - 1e-08 35.1 7.0 1e-08 35.1 7.0 3.0 2 2 1 3 3 3 1 Ion channel regulatory protein UNC-93 DUF5542 PF17696.1 EGD96753.1 - 0.078 13.1 0.0 0.19 11.9 0.0 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5542) Bac_export_2 PF01312.19 EGD96753.1 - 7.3 5.7 9.0 0.13 11.4 0.2 2.4 3 0 0 3 3 3 0 FlhB HrpN YscU SpaS Family BcrAD_BadFG PF01869.20 EGD96754.1 - 6.2e-08 32.5 0.0 1.1e-07 31.7 0.0 1.5 1 0 0 1 1 1 1 BadF/BadG/BcrA/BcrD ATPase family SIS_2 PF13580.6 EGD96754.1 - 1.2e-05 25.4 0.0 4.2e-05 23.6 0.0 1.9 1 1 0 1 1 1 1 SIS domain SIS PF01380.22 EGD96754.1 - 0.001 18.9 0.1 0.0063 16.4 0.0 2.2 2 0 0 2 2 2 1 SIS domain ADP_ribosyl_GH PF03747.14 EGD96755.1 - 2.5e-57 194.9 0.0 3.1e-57 194.5 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylglycohydrolase DUF973 PF06157.11 EGD96756.1 - 0.022 13.8 13.4 0.006 15.7 8.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF973) DUF373 PF04123.13 EGD96756.1 - 9.2 5.6 16.1 6.5 6.1 11.0 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF373) DnaJ PF00226.31 EGD96757.1 - 2.2e-10 40.5 0.1 1.6e-09 37.7 0.1 2.3 2 0 0 2 2 2 1 DnaJ domain SEEEED PF14797.6 EGD96757.1 - 3.5 7.8 10.9 0.041 14.0 2.5 1.9 2 0 0 2 2 2 0 Serine-rich region of AP3B1, clathrin-adaptor complex PRA1 PF03208.19 EGD96758.1 - 1.2e-27 96.3 2.4 1.7e-27 95.8 2.4 1.2 1 0 0 1 1 1 1 PRA1 family protein FAM176 PF14851.6 EGD96758.1 - 0.0035 17.0 1.3 0.0035 17.0 1.3 2.5 1 1 1 2 2 2 1 FAM176 family SDA1 PF05285.12 EGD96758.1 - 1.2 8.5 16.2 2 7.8 16.2 1.3 1 0 0 1 1 1 0 SDA1 DNA_pol_phi PF04931.13 EGD96758.1 - 3.2 5.8 21.8 4.3 5.3 21.8 1.1 1 0 0 1 1 1 0 DNA polymerase phi Frag1 PF10277.9 EGD96759.1 - 3.1e-38 131.5 12.5 3.6e-38 131.3 12.5 1.0 1 0 0 1 1 1 1 Frag1/DRAM/Sfk1 family DUF4436 PF14494.6 EGD96759.1 - 0.05 12.9 1.7 0.084 12.2 1.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4436) DUF5134 PF17197.4 EGD96759.1 - 0.44 10.4 3.6 0.66 9.9 0.1 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF5134) DUF2070 PF09843.9 EGD96759.1 - 7.1 4.8 18.4 0.11 10.8 10.2 1.8 1 1 1 2 2 2 0 Predicted membrane protein (DUF2070) Peroxin-3 PF04882.12 EGD96762.1 - 3.8 6.4 8.5 4.3 6.2 8.5 1.1 1 0 0 1 1 1 0 Peroxin-3 SNF2_N PF00176.23 EGD96763.1 - 3e-58 197.2 0.0 5.8e-58 196.3 0.0 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain zf-C3HC4_2 PF13923.6 EGD96763.1 - 2e-09 37.1 8.4 5.9e-09 35.6 8.4 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EGD96763.1 - 2.6e-09 36.8 8.0 9.1e-09 35.1 8.0 2.1 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EGD96763.1 - 6.6e-08 32.3 7.7 1.9e-07 30.9 7.7 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EGD96763.1 - 8.9e-08 32.3 10.8 2.6e-07 30.9 10.8 1.9 1 0 0 1 1 1 1 Ring finger domain Prok-RING_4 PF14447.6 EGD96763.1 - 5.5e-06 26.1 8.3 1.2e-05 25.1 8.3 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-rbx1 PF12678.7 EGD96763.1 - 1.6e-05 25.1 8.0 5.3e-05 23.4 8.0 1.9 1 0 0 1 1 1 1 RING-H2 zinc finger domain Helicase_C PF00271.31 EGD96763.1 - 1.9e-05 25.0 0.0 6.6e-05 23.2 0.0 2.0 2 0 0 2 2 1 1 Helicase conserved C-terminal domain zf-RING_UBOX PF13445.6 EGD96763.1 - 2.1e-05 24.4 4.3 3.7e-05 23.6 3.1 2.2 1 1 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 EGD96763.1 - 0.00031 20.6 6.5 0.0009 19.2 6.5 1.9 1 0 0 1 1 1 1 zinc-RING finger domain ResIII PF04851.15 EGD96763.1 - 0.00048 20.2 0.0 0.0036 17.3 0.0 2.5 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit zf-C3HC4_4 PF15227.6 EGD96763.1 - 0.0021 18.2 7.8 0.0053 16.9 7.8 1.7 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-ANAPC11 PF12861.7 EGD96763.1 - 0.16 12.0 3.8 0.39 10.8 3.8 1.7 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Baculo_IE-1 PF05290.11 EGD96763.1 - 0.17 11.8 2.7 0.49 10.3 2.7 1.7 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) zf-RING_10 PF16685.5 EGD96763.1 - 0.18 11.9 4.9 0.47 10.6 4.9 1.7 1 0 0 1 1 1 0 zinc RING finger of MSL2 Voldacs PF03517.13 EGD96763.1 - 0.2 11.8 4.6 13 5.9 0.1 3.8 3 0 0 3 3 3 0 Regulator of volume decrease after cellular swelling Zn_ribbon_17 PF17120.5 EGD96763.1 - 0.33 10.6 7.6 0.81 9.4 7.6 1.6 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-RING_4 PF14570.6 EGD96763.1 - 0.34 10.7 7.4 0.91 9.4 7.4 1.8 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-P11 PF03854.14 EGD96763.1 - 1.5 8.6 6.0 3.6 7.3 6.0 1.7 1 0 0 1 1 1 0 P-11 zinc finger Mito_carr PF00153.27 EGD96764.1 - 2.5e-64 213.3 0.6 2.3e-21 75.5 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Bacteriocin_IIc PF10439.9 EGD96764.1 - 0.067 13.3 1.5 3.9 7.7 0.2 2.6 2 0 0 2 2 2 0 Bacteriocin class II with double-glycine leader peptide Serine_protease PF18405.1 EGD96764.1 - 0.22 10.6 0.2 3.9 6.5 0.0 2.7 2 1 0 2 2 2 0 Gammaproteobacterial serine protease Ecm29 PF13001.7 EGD96765.1 - 1.5e-154 515.4 0.3 1.5e-150 502.2 0.0 4.7 3 2 2 5 5 5 2 Proteasome stabiliser HEAT PF02985.22 EGD96765.1 - 1.9e-05 24.5 5.5 0.69 10.3 0.1 8.8 10 0 0 10 10 10 1 HEAT repeat HEAT_2 PF13646.6 EGD96765.1 - 0.0041 17.5 9.1 6.4 7.2 0.1 6.5 6 3 1 7 7 7 2 HEAT repeats HEAT_EZ PF13513.6 EGD96765.1 - 0.0043 17.5 6.6 0.64 10.6 0.0 6.1 6 0 0 6 6 6 1 HEAT-like repeat Vac14_Fab1_bd PF12755.7 EGD96765.1 - 0.04 14.5 3.0 0.44 11.2 0.1 4.5 5 1 0 5 5 5 0 Vacuolar 14 Fab1-binding region Fungal_trans_2 PF11951.8 EGD96767.1 - 5e-21 74.9 1.4 9.7e-20 70.7 1.4 2.1 1 1 0 1 1 1 1 Fungal specific transcription factor domain WW PF00397.26 EGD96768.1 - 1e-11 44.7 0.6 2.5e-11 43.4 0.6 1.7 1 0 0 1 1 1 1 WW domain DUF4585 PF15232.6 EGD96768.1 - 0.036 14.1 0.0 0.036 14.1 0.0 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4585) PhoD PF09423.10 EGD96768.1 - 0.08 11.9 0.2 0.15 11.0 0.2 1.4 1 0 0 1 1 1 0 PhoD-like phosphatase Lipase_3 PF01764.25 EGD96769.1 - 9.5e-30 103.3 0.0 1.4e-29 102.8 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) Esterase PF00756.20 EGD96769.1 - 0.00079 19.1 0.0 0.0014 18.4 0.0 1.3 1 0 0 1 1 1 1 Putative esterase Abhydrolase_6 PF12697.7 EGD96769.1 - 0.0074 16.9 0.1 0.011 16.4 0.1 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family GHMP_kinases_C PF08544.13 EGD96769.1 - 0.038 14.4 0.0 0.11 12.8 0.0 1.7 2 0 0 2 2 2 0 GHMP kinases C terminal Abhydrolase_5 PF12695.7 EGD96769.1 - 0.051 13.3 0.0 0.086 12.6 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family Op_neuropeptide PF08035.11 EGD96769.1 - 0.1 12.5 0.1 0.2 11.6 0.1 1.5 1 0 0 1 1 1 0 Opioids neuropeptide DUF2974 PF11187.8 EGD96769.1 - 0.12 12.0 0.0 1.7 8.2 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2974) Hydrolase_4 PF12146.8 EGD96769.1 - 0.23 10.7 0.0 0.38 10.0 0.0 1.2 1 0 0 1 1 1 0 Serine aminopeptidase, S33 WD40 PF00400.32 EGD96770.1 - 2.4e-16 59.8 10.8 0.00059 20.6 0.2 6.5 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EGD96770.1 - 1.3e-06 28.6 0.0 0.0013 19.0 0.0 3.7 4 1 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EGD96770.1 - 0.028 13.4 0.1 6.3 5.6 0.0 3.4 4 0 0 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Chi-conotoxin PF16981.5 EGD96770.1 - 0.18 12.0 0.1 0.74 10.1 0.1 2.0 1 1 0 1 1 1 0 chi-Conotoxin or t superfamily RRM_1 PF00076.22 EGD96771.1 - 1.6e-07 31.0 0.0 3.8e-07 29.8 0.0 1.6 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EGD96771.1 - 0.00019 21.0 0.0 0.00027 20.5 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EGD96771.1 - 0.0097 15.7 0.0 0.015 15.2 0.0 1.3 1 0 0 1 1 1 1 Occluded RNA-recognition motif Limkain-b1 PF11608.8 EGD96771.1 - 0.13 12.4 0.0 0.26 11.4 0.0 1.4 1 0 0 1 1 1 0 Limkain b1 Autophagy_act_C PF03987.15 EGD96772.1 - 5e-14 52.6 0.0 2.9e-13 50.2 0.1 2.0 2 0 0 2 2 2 1 Autophagocytosis associated protein, active-site domain Sulfatase PF00884.23 EGD96773.1 - 5.1e-78 262.6 0.0 6.4e-78 262.3 0.0 1.1 1 0 0 1 1 1 1 Sulfatase DUF229 PF02995.17 EGD96773.1 - 2.1e-05 23.3 0.0 2.9e-05 22.9 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF229) MFS_1 PF07690.16 EGD96775.1 - 1.7e-29 102.9 60.4 1e-27 97.0 40.8 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EGD96775.1 - 4.3e-08 32.5 38.3 0.00062 18.7 15.4 2.7 2 1 0 2 2 2 2 Sugar (and other) transporter Bac_rhodopsin PF01036.18 EGD96776.1 - 8e-36 123.7 19.7 9.1e-36 123.5 19.7 1.0 1 0 0 1 1 1 1 Bacteriorhodopsin-like protein AcrZ PF10766.9 EGD96776.1 - 0.42 10.2 3.6 0.67 9.6 0.1 2.4 2 0 0 2 2 2 0 Multidrug efflux pump-associated protein AcrZ HSP20 PF00011.21 EGD96779.1 - 3.5e-18 65.6 0.2 3.2e-12 46.5 0.0 2.4 2 0 0 2 2 2 2 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 EGD96779.1 - 4.1e-06 26.2 0.0 0.0067 16.0 0.0 2.3 2 0 0 2 2 2 2 HSP20-like domain found in ArsA Complex1_LYR PF05347.15 EGD96780.1 - 2.8e-17 62.5 1.7 3.4e-17 62.2 1.7 1.1 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 EGD96780.1 - 1.5e-06 28.9 0.5 1.8e-06 28.6 0.5 1.1 1 0 0 1 1 1 1 Complex1_LYR-like Complex1_LYR_1 PF13232.6 EGD96780.1 - 0.047 14.3 0.1 0.06 14.0 0.1 1.2 1 0 0 1 1 1 0 Complex1_LYR-like FAA_hydrolase PF01557.18 EGD96781.1 - 6.4e-65 218.9 0.0 8.6e-65 218.4 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family Proteasome PF00227.26 EGD96782.1 - 3.9e-30 104.7 0.0 4.8e-30 104.5 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Gal4_dimer PF03902.13 EGD96782.1 - 0.14 12.3 0.0 0.33 11.1 0.0 1.6 1 0 0 1 1 1 0 Gal4-like dimerisation domain HCNGP PF07818.13 EGD96783.1 - 7.2e-32 109.9 0.3 1.6e-31 108.8 0.3 1.6 1 0 0 1 1 1 1 HCNGP-like protein Ketoacyl-synt_C PF02801.22 EGD96783.1 - 0.058 13.4 0.0 0.11 12.5 0.0 1.4 1 0 0 1 1 1 0 Beta-ketoacyl synthase, C-terminal domain Proteasome PF00227.26 EGD96784.1 - 6.2e-32 110.6 0.1 1.6e-31 109.3 0.1 1.6 2 0 0 2 2 2 1 Proteasome subunit DUF974 PF06159.13 EGD96784.1 - 0.069 12.9 0.0 0.096 12.5 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF974) KH_8 PF17903.1 EGD96785.1 - 1.4e-05 25.1 0.0 2.8e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 Krr1 KH1 domain KH_1 PF00013.29 EGD96785.1 - 0.1 12.5 2.1 0.098 12.5 0.6 1.7 2 0 0 2 2 2 0 KH domain MDM31_MDM32 PF08118.11 EGD96786.1 - 1.4e-181 604.7 0.4 1.3e-180 601.6 0.4 1.9 1 1 0 1 1 1 1 Yeast mitochondrial distribution and morphology (MDM) proteins RhoGAP PF00620.27 EGD96787.1 - 6.1e-40 136.5 0.0 1.4e-39 135.4 0.0 1.6 1 0 0 1 1 1 1 RhoGAP domain PH PF00169.29 EGD96787.1 - 2.3e-14 53.8 0.6 5.7e-14 52.5 0.0 2.1 2 0 0 2 2 2 1 PH domain R_equi_Vir PF05526.11 EGD96787.1 - 0.0022 17.9 1.3 0.0084 16.0 1.3 2.0 1 0 0 1 1 1 1 Rhodococcus equi virulence-associated protein PH_8 PF15409.6 EGD96787.1 - 0.0086 16.3 0.1 0.03 14.6 0.0 1.9 2 0 0 2 2 2 1 Pleckstrin homology domain Peptidase_C25 PF01364.18 EGD96787.1 - 0.033 13.4 0.5 0.062 12.5 0.5 1.3 1 0 0 1 1 1 0 Peptidase family C25 DivIC PF04977.15 EGD96787.1 - 0.86 9.4 5.3 8.4 6.3 5.1 2.6 2 0 0 2 2 2 0 Septum formation initiator HrpB7 PF09486.10 EGD96787.1 - 5.9 7.3 18.1 2.1 8.8 2.3 3.3 3 0 0 3 3 3 0 Bacterial type III secretion protein (HrpB7) Erv26 PF04148.13 EGD96788.1 - 1.2e-92 309.4 0.1 1.4e-92 309.2 0.1 1.0 1 0 0 1 1 1 1 Transmembrane adaptor Erv26 Ferric_reduct PF01794.19 EGD96788.1 - 0.009 16.1 3.7 0.13 12.4 3.7 2.2 1 1 0 1 1 1 1 Ferric reductase like transmembrane component WBS_methylT PF12589.8 EGD96789.1 - 3.2e-15 56.6 3.9 5.6e-15 55.9 3.9 1.3 1 0 0 1 1 1 1 Methyltransferase involved in Williams-Beuren syndrome Methyltransf_11 PF08241.12 EGD96789.1 - 2.2e-11 44.2 0.0 4.1e-11 43.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EGD96789.1 - 2.3e-10 41.1 0.0 7.7e-10 39.4 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EGD96789.1 - 3.8e-05 24.4 0.0 9.4e-05 23.1 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EGD96789.1 - 0.00015 21.6 0.0 0.00023 21.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 EGD96789.1 - 0.00048 19.9 0.0 0.0009 19.1 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Ubie_methyltran PF01209.18 EGD96789.1 - 0.0024 17.2 0.0 0.021 14.1 0.0 2.2 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.6 EGD96789.1 - 0.0046 16.8 0.0 0.0074 16.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 EGD96789.1 - 0.041 13.2 0.0 0.5 9.6 0.0 2.0 2 0 0 2 2 2 0 Mycolic acid cyclopropane synthetase ACT_7 PF13840.6 EGD96789.1 - 0.21 11.4 0.1 0.46 10.3 0.1 1.5 1 0 0 1 1 1 0 ACT domain Iso_dh PF00180.20 EGD96790.1 - 9.1e-84 281.6 0.0 1.1e-83 281.3 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Peptidase_S46 PF10459.9 EGD96791.1 - 0.067 11.8 1.9 0.081 11.6 1.9 1.0 1 0 0 1 1 1 0 Peptidase S46 NdhL PF10716.9 EGD96791.1 - 0.075 13.0 0.3 0.13 12.2 0.3 1.3 1 0 0 1 1 1 0 NADH dehydrogenase transmembrane subunit PspB PF06667.12 EGD96791.1 - 0.31 11.1 5.5 0.49 10.5 5.1 1.6 1 1 0 1 1 1 0 Phage shock protein B DUF3270 PF11674.8 EGD96791.1 - 4 7.7 4.9 14 6.0 4.9 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3270) Vps36-NZF-N PF16988.5 EGD96792.1 - 0.14 11.5 0.0 0.39 10.1 0.0 1.7 1 0 0 1 1 1 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain Proteasome PF00227.26 EGD96793.1 - 1.7e-45 154.8 0.3 4e-32 111.2 0.0 2.7 3 0 0 3 3 3 2 Proteasome subunit Proteasome_A_N PF10584.9 EGD96793.1 - 5.2e-12 45.2 1.0 6.5e-12 44.9 0.0 1.7 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature RNA_pol_3_Rpc31 PF11705.8 EGD96793.1 - 0.17 12.1 10.9 0.24 11.6 10.9 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 NOA36 PF06524.12 EGD96793.1 - 1.3 8.3 10.3 1.7 7.9 10.3 1.2 1 0 0 1 1 1 0 NOA36 protein UPF0560 PF10577.9 EGD96793.1 - 1.4 7.3 4.6 1.7 7.1 4.6 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 DUF4611 PF15387.6 EGD96793.1 - 2 8.7 11.0 3.7 7.8 11.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) PBP1_TM PF14812.6 EGD96793.1 - 3.5 8.0 11.4 6.4 7.2 11.4 1.5 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal FAM176 PF14851.6 EGD96793.1 - 8.5 6.0 8.6 12 5.5 8.6 1.3 1 0 0 1 1 1 0 FAM176 family DMRL_synthase PF00885.19 EGD96794.1 - 3.1e-56 189.1 0.2 3.8e-56 188.8 0.2 1.1 1 0 0 1 1 1 1 6,7-dimethyl-8-ribityllumazine synthase Copper-fist PF00649.18 EGD96795.1 - 5.2e-23 80.2 1.4 1.4e-22 78.9 1.4 1.8 1 0 0 1 1 1 1 Copper fist DNA binding domain Zn_clus PF00172.18 EGD96796.1 - 2.7e-10 40.2 9.6 4e-10 39.6 9.6 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain RskA PF10099.9 EGD96796.1 - 0.24 11.7 29.0 0.085 13.2 6.4 2.8 3 0 0 3 3 3 0 Anti-sigma-K factor rskA F-box-like PF12937.7 EGD96797.1 - 6.8e-06 25.9 1.1 2.7e-05 24.0 1.1 2.0 1 1 0 1 1 1 1 F-box-like SUIM_assoc PF16619.5 EGD96797.1 - 0.0069 16.4 2.4 0.016 15.3 2.4 1.6 1 0 0 1 1 1 1 Unstructured region C-term to UIM in Ataxin3 Dehydrin PF00257.19 EGD96797.1 - 0.037 14.6 0.5 0.055 14.0 0.5 1.2 1 0 0 1 1 1 0 Dehydrin Androgen_recep PF02166.16 EGD96797.1 - 0.072 11.9 2.0 0.1 11.4 2.0 1.1 1 0 0 1 1 1 0 Androgen receptor DUF4571 PF15137.6 EGD96797.1 - 0.18 11.5 0.0 0.33 10.6 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4571) F-box PF00646.33 EGD96797.1 - 7 6.7 6.5 1.1e+02 2.8 6.5 2.4 1 1 0 1 1 1 0 F-box domain Pyr_redox_3 PF13738.6 EGD96798.1 - 4.1e-16 59.1 0.0 5.9e-15 55.3 0.0 2.4 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.19 EGD96798.1 - 2.1e-13 49.6 0.0 1.5e-11 43.4 0.0 2.2 2 0 0 2 2 2 1 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.14 EGD96798.1 - 2.4e-12 46.7 0.0 2.5e-10 40.1 0.0 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EGD96798.1 - 5.9e-11 42.1 0.0 1.3e-07 31.1 0.0 2.8 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) Thi4 PF01946.17 EGD96798.1 - 4.7e-07 29.3 0.1 2e-06 27.2 0.0 1.9 2 0 0 2 2 2 1 Thi4 family NAD_binding_8 PF13450.6 EGD96798.1 - 0.00015 21.9 0.5 0.00086 19.5 0.0 2.3 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 EGD96798.1 - 0.00023 21.2 0.0 0.084 12.9 0.0 2.7 2 1 0 2 2 2 1 FAD-NAD(P)-binding Pyr_redox PF00070.27 EGD96798.1 - 0.00059 20.3 1.4 0.27 11.8 0.1 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EGD96798.1 - 0.0009 18.7 0.1 0.74 9.1 0.0 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 EGD96798.1 - 0.0047 16.0 0.5 0.1 11.6 0.0 2.4 3 0 0 3 3 3 1 Lycopene cyclase protein FAD_binding_2 PF00890.24 EGD96798.1 - 0.0076 15.4 1.3 0.51 9.4 0.0 2.5 3 0 0 3 3 3 1 FAD binding domain NAD_binding_7 PF13241.6 EGD96798.1 - 0.0077 16.6 0.0 0.73 10.3 0.0 2.4 2 0 0 2 2 2 1 Putative NAD(P)-binding DAO PF01266.24 EGD96798.1 - 0.011 15.3 0.1 0.55 9.8 0.1 2.6 3 0 0 3 3 3 0 FAD dependent oxidoreductase Amino_oxidase PF01593.24 EGD96798.1 - 0.014 14.7 0.0 4 6.6 0.0 2.4 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase HI0933_like PF03486.14 EGD96798.1 - 0.042 12.6 2.6 0.33 9.6 0.1 2.9 3 0 0 3 3 3 0 HI0933-like protein DUF4147 PF13660.6 EGD96798.1 - 0.08 12.5 0.0 0.14 11.6 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4147) Arf PF00025.21 EGD96800.1 - 1.8e-73 245.7 0.1 2.2e-73 245.4 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EGD96800.1 - 3.9e-14 52.9 0.0 5.3e-14 52.5 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EGD96800.1 - 8.6e-12 44.9 0.0 9.8e-12 44.8 0.0 1.1 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 EGD96800.1 - 1.7e-11 43.9 0.0 2.1e-11 43.6 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region G-alpha PF00503.20 EGD96800.1 - 2.6e-11 43.3 1.5 3e-07 29.9 0.3 2.3 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.10 EGD96800.1 - 2.6e-11 43.3 0.0 3.1e-11 43.0 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 EGD96800.1 - 0.00016 21.7 0.0 0.00044 20.3 0.0 1.7 1 1 1 2 2 2 1 50S ribosome-binding GTPase 6PF2K PF01591.18 EGD96800.1 - 0.033 13.5 0.3 0.053 12.8 0.1 1.4 2 0 0 2 2 2 0 6-phosphofructo-2-kinase ANAPC4_WD40 PF12894.7 EGD96801.1 - 9.8e-12 45.0 0.0 6.7e-05 23.1 0.0 3.3 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EGD96801.1 - 4e-10 40.1 16.6 0.00033 21.4 0.3 5.9 5 1 0 5 5 5 3 WD domain, G-beta repeat eIF2A PF08662.11 EGD96801.1 - 0.0021 18.0 0.0 0.022 14.7 0.0 2.1 1 1 1 2 2 2 1 Eukaryotic translation initiation factor eIF2A IKI3 PF04762.12 EGD96801.1 - 0.0038 15.3 0.0 0.0099 13.9 0.0 1.5 1 1 1 2 2 2 1 IKI3 family Vps16_N PF04841.13 EGD96801.1 - 0.066 11.9 0.0 4 6.1 0.0 2.1 1 1 0 2 2 2 0 Vps16, N-terminal region Lgl_C PF08596.10 EGD96801.1 - 0.095 11.4 0.0 0.17 10.5 0.0 1.3 1 0 0 1 1 1 0 Lethal giant larvae(Lgl) like, C-terminal Cytochrom_D1 PF02239.16 EGD96801.1 - 0.12 10.9 0.0 0.21 10.0 0.0 1.4 1 0 0 1 1 1 0 Cytochrome D1 heme domain YpsA PF06908.11 EGD96801.1 - 0.14 12.1 0.0 0.25 11.3 0.0 1.3 1 0 0 1 1 1 0 YspA SLOG family ArAE_2_N PF10337.9 EGD96802.1 - 2.5e-21 76.3 0.4 2.5e-21 76.3 0.4 3.3 2 1 1 3 3 3 2 Putative ER transporter, 6TM, N-terminal FUSC_2 PF13515.6 EGD96802.1 - 1.4e-11 44.6 12.4 1.4e-11 44.6 12.4 3.7 4 1 0 4 4 4 1 Fusaric acid resistance protein-like ArAE_2 PF10334.9 EGD96802.1 - 7.7e-09 35.7 0.1 8.1e-08 32.4 0.0 2.2 2 0 0 2 2 2 1 Aromatic acid exporter family member 2 Zds_C PF08632.10 EGD96803.1 - 2e-28 97.9 1.6 2e-28 97.9 1.6 2.0 2 0 0 2 2 2 1 Activator of mitotic machinery Cdc14 phosphatase activation C-term Ysc84 PF04366.12 EGD96804.1 - 9.2e-43 145.0 0.3 1.8e-42 144.1 0.3 1.5 1 0 0 1 1 1 1 Las17-binding protein actin regulator SH3_1 PF00018.28 EGD96804.1 - 1e-12 47.4 0.1 5.2e-12 45.2 0.1 2.0 2 0 0 2 2 2 1 SH3 domain SH3_2 PF07653.17 EGD96804.1 - 1.9e-11 43.5 0.0 4.6e-11 42.2 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 EGD96804.1 - 1.1e-10 41.2 0.0 1.9e-10 40.5 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain EF_assoc_2 PF08356.12 EGD96805.1 - 8.5e-35 118.6 0.0 1.6e-34 117.7 0.0 1.5 1 0 0 1 1 1 1 EF hand associated EF_assoc_1 PF08355.12 EGD96805.1 - 2e-30 104.2 0.5 3.4e-30 103.5 0.5 1.4 1 0 0 1 1 1 1 EF hand associated Ras PF00071.22 EGD96805.1 - 4.6e-24 84.9 0.0 8.3e-14 51.5 0.0 2.2 2 0 0 2 2 2 2 Ras family Roc PF08477.13 EGD96805.1 - 3.8e-13 49.7 0.0 2.4e-08 34.2 0.0 2.4 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 EGD96805.1 - 2.2e-09 37.4 0.0 3.9e-05 23.7 0.0 2.5 2 0 0 2 2 2 2 50S ribosome-binding GTPase EF-hand_6 PF13405.6 EGD96805.1 - 1.2e-07 31.1 0.3 0.02 14.8 0.0 2.9 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 EGD96805.1 - 4.1e-07 29.1 3.5 0.0057 16.1 0.1 3.0 3 0 0 3 3 2 2 EF hand EF-hand_7 PF13499.6 EGD96805.1 - 9e-07 29.3 1.1 0.0031 17.9 0.2 3.0 3 0 0 3 3 2 2 EF-hand domain pair AAA_16 PF13191.6 EGD96805.1 - 1.2e-05 25.7 0.0 0.042 14.2 0.0 2.6 2 0 0 2 2 2 2 AAA ATPase domain AAA_29 PF13555.6 EGD96805.1 - 2e-05 24.2 0.1 0.016 14.9 0.0 2.4 2 0 0 2 2 2 1 P-loop containing region of AAA domain EF-hand_10 PF14788.6 EGD96805.1 - 2.9e-05 23.9 2.3 0.0057 16.5 0.3 2.4 2 0 0 2 2 2 1 EF hand Dynamin_N PF00350.23 EGD96805.1 - 0.00012 22.2 1.8 0.99 9.4 0.0 3.7 5 0 0 5 5 4 2 Dynamin family AAA_22 PF13401.6 EGD96805.1 - 0.00032 21.0 0.0 1.2 9.4 0.0 2.5 2 0 0 2 2 2 2 AAA domain RsgA_GTPase PF03193.16 EGD96805.1 - 0.00094 19.1 0.1 1.9 8.4 0.1 3.3 3 0 0 3 3 3 1 RsgA GTPase Viral_helicase1 PF01443.18 EGD96805.1 - 0.0027 17.5 0.2 0.11 12.3 0.0 2.7 2 1 0 2 2 2 1 Viral (Superfamily 1) RNA helicase EF-hand_8 PF13833.6 EGD96805.1 - 0.0048 16.7 0.2 0.81 9.6 0.0 2.6 2 0 0 2 2 2 1 EF-hand domain pair AAA_28 PF13521.6 EGD96805.1 - 0.0052 17.0 0.0 3.1 8.0 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 EGD96805.1 - 0.0055 17.3 0.1 2 8.9 0.2 2.7 2 0 0 2 2 2 1 AAA domain Ploopntkinase3 PF18751.1 EGD96805.1 - 0.0066 16.4 0.0 0.72 9.7 0.0 2.2 2 0 0 2 2 2 1 P-loop Nucleotide Kinase3 NACHT PF05729.12 EGD96805.1 - 0.0079 16.1 0.1 4.8 7.1 0.0 2.7 2 0 0 2 2 2 0 NACHT domain RNA_helicase PF00910.22 EGD96805.1 - 0.0082 16.5 0.0 1.1 9.7 0.0 2.6 2 0 0 2 2 2 1 RNA helicase GTP_EFTU PF00009.27 EGD96805.1 - 0.0093 15.5 0.0 11 5.5 0.0 3.2 3 0 0 3 3 3 0 Elongation factor Tu GTP binding domain ABC_tran PF00005.27 EGD96805.1 - 0.012 16.2 0.0 7.2 7.1 0.0 2.4 2 0 0 2 2 2 0 ABC transporter Septin PF00735.18 EGD96805.1 - 0.014 14.7 0.0 0.88 8.8 0.1 2.3 2 0 0 2 2 2 0 Septin AAA_25 PF13481.6 EGD96805.1 - 0.015 14.9 0.1 3.1 7.3 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 EGD96805.1 - 0.018 15.2 0.3 4.1 7.6 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 EGD96805.1 - 0.027 14.2 0.1 0.54 9.9 0.1 2.3 2 0 0 2 2 2 0 AAA domain FtsK_SpoIIIE PF01580.18 EGD96805.1 - 0.032 13.6 0.2 2.7 7.3 0.0 2.2 2 0 0 2 2 2 0 FtsK/SpoIIIE family MCM PF00493.23 EGD96805.1 - 0.033 13.3 0.0 1.7 7.7 0.0 2.4 2 0 0 2 2 2 0 MCM P-loop domain AAA_7 PF12775.7 EGD96805.1 - 0.046 13.2 0.1 1.9 8.0 0.1 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region ATP_bind_1 PF03029.17 EGD96805.1 - 0.052 13.3 3.0 3 7.6 0.0 3.3 4 0 0 4 4 3 0 Conserved hypothetical ATP binding protein SMC_N PF02463.19 EGD96805.1 - 0.068 12.6 0.3 2.1 7.8 0.0 2.2 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain AAA_5 PF07728.14 EGD96805.1 - 0.085 12.9 0.3 26 4.8 0.0 3.0 2 1 1 3 3 3 0 AAA domain (dynein-related subfamily) DUF815 PF05673.13 EGD96805.1 - 0.089 11.9 0.2 2.7 7.1 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF815) EF-hand_5 PF13202.6 EGD96805.1 - 0.099 12.2 6.1 0.87 9.2 0.3 3.0 3 0 0 3 3 2 0 EF hand Zeta_toxin PF06414.12 EGD96805.1 - 0.14 11.4 0.0 1.7 7.9 0.0 2.2 2 0 0 2 2 2 0 Zeta toxin AAA PF00004.29 EGD96805.1 - 0.15 12.5 0.4 16 5.9 0.1 3.0 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) cobW PF02492.19 EGD96805.1 - 1.1 8.8 2.4 8.7 5.9 0.0 3.1 4 1 0 5 5 4 0 CobW/HypB/UreG, nucleotide-binding domain Synaptobrevin PF00957.21 EGD96806.1 - 0.1 12.4 4.1 2.8 7.8 0.5 2.1 1 1 1 2 2 2 0 Synaptobrevin Fib_alpha PF08702.10 EGD96806.1 - 0.23 11.7 1.5 0.27 11.4 1.5 1.1 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family DUF1771 PF08590.10 EGD96807.1 - 2.2e-11 44.0 5.0 5.7e-11 42.6 5.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1771) CUE PF02845.16 EGD96807.1 - 2.6e-08 33.4 0.0 2.7e-07 30.1 0.0 2.8 2 0 0 2 2 2 1 CUE domain Smr PF01713.21 EGD96807.1 - 1.4e-05 25.4 0.2 4.3e-05 23.8 0.2 1.8 1 0 0 1 1 1 1 Smr domain SelR PF01641.18 EGD96808.1 - 1e-50 170.8 0.2 1.2e-50 170.6 0.2 1.0 1 0 0 1 1 1 1 SelR domain zinc_ribbon_10 PF10058.9 EGD96808.1 - 0.019 14.7 0.2 0.54 10.0 0.0 2.2 2 0 0 2 2 2 0 Predicted integral membrane zinc-ribbon metal-binding protein Yippee-Mis18 PF03226.14 EGD96808.1 - 0.028 14.6 1.4 0.12 12.6 1.4 1.9 1 1 0 1 1 1 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly DZR PF12773.7 EGD96808.1 - 0.38 10.8 3.8 7 6.8 3.8 2.3 1 1 1 2 2 2 0 Double zinc ribbon ArfGap PF01412.18 EGD96809.1 - 1.3e-39 134.9 2.5 1.9e-39 134.3 2.5 1.3 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf GPI-anchored PF10342.9 EGD96810.1 - 1.9e-11 44.6 0.0 3.1e-11 43.9 0.0 1.3 1 0 0 1 1 1 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family DJ-1_PfpI PF01965.24 EGD96811.1 - 2.8e-11 43.5 0.0 3.2e-11 43.3 0.0 1.1 1 0 0 1 1 1 1 DJ-1/PfpI family DUF3328 PF11807.8 EGD96812.1 - 0.0012 18.7 0.0 0.002 18.0 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) RFX_DNA_binding PF02257.15 EGD96812.1 - 0.11 13.1 0.0 0.25 12.0 0.0 1.6 1 0 0 1 1 1 0 RFX DNA-binding domain ARID PF01388.21 EGD96813.1 - 1.6e-10 41.5 0.0 2e-10 41.2 0.0 1.1 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain Amidase PF01425.21 EGD96814.1 - 4.3e-68 230.3 0.0 2.9e-66 224.3 0.0 2.0 1 1 0 1 1 1 1 Amidase PEX11 PF05648.14 EGD96815.1 - 5.8e-69 232.0 0.1 6.5e-69 231.8 0.1 1.0 1 0 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) Sugar_tr PF00083.24 EGD96816.1 - 3.8e-33 115.0 24.3 1.1e-21 77.2 7.2 2.1 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 EGD96816.1 - 8.4e-19 67.7 63.5 8.9e-18 64.3 39.9 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily PEPCK_ATP PF01293.20 EGD96817.1 - 2.6e-217 722.1 0.0 3.1e-217 721.8 0.0 1.1 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase Sde2_N_Ubi PF13019.6 EGD96818.1 - 0.016 15.1 0.3 0.026 14.3 0.3 1.4 1 0 0 1 1 1 0 Silencing defective 2 N-terminal ubiquitin domain Aminotran_1_2 PF00155.21 EGD96819.1 - 1.6e-38 132.8 0.0 2.1e-38 132.5 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II TetR_C_14 PF17754.1 EGD96819.1 - 0.17 11.8 0.0 0.44 10.5 0.0 1.6 1 0 0 1 1 1 0 MftR C-terminal domain RPN7 PF10602.9 EGD96820.1 - 7.8e-55 185.2 0.5 1.5e-54 184.4 0.5 1.5 1 0 0 1 1 1 1 26S proteasome subunit RPN7 PCI PF01399.27 EGD96820.1 - 8.3e-12 45.6 0.0 1.8e-11 44.5 0.0 1.6 1 0 0 1 1 1 1 PCI domain TPR_7 PF13176.6 EGD96820.1 - 0.11 12.5 2.0 0.51 10.5 0.0 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat MIS13 PF08202.11 EGD96821.1 - 2.1e-43 148.7 4.7 2.1e-43 148.7 4.7 2.8 2 1 0 2 2 2 1 Mis12-Mtw1 protein family GGN PF15685.5 EGD96821.1 - 0.00018 20.7 5.0 0.00018 20.7 5.0 2.2 2 0 0 2 2 2 1 Gametogenetin DivIC PF04977.15 EGD96821.1 - 0.017 14.9 0.1 0.051 13.3 0.1 1.8 1 0 0 1 1 1 0 Septum formation initiator Sugar_tr PF00083.24 EGD96822.1 - 5.7e-86 289.2 24.2 1e-85 288.3 24.2 1.4 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EGD96822.1 - 6.5e-33 114.1 42.9 1.2e-23 83.7 10.4 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily MFS_4 PF06779.14 EGD96822.1 - 6.8e-06 25.6 4.8 6.8e-06 25.6 4.8 3.0 2 1 1 3 3 3 1 Uncharacterised MFS-type transporter YbfB OATP PF03137.20 EGD96822.1 - 0.0051 15.2 2.0 0.0051 15.2 2.0 2.0 2 1 0 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family AMP-binding PF00501.28 EGD96823.1 - 3.6e-50 170.8 2.4 7e-49 166.6 2.4 2.2 1 1 0 1 1 1 1 AMP-binding enzyme Condensation PF00668.20 EGD96823.1 - 2.2e-48 165.1 0.0 3.8e-48 164.3 0.0 1.3 1 0 0 1 1 1 1 Condensation domain Acyl_transf_1 PF00698.21 EGD96823.1 - 1.4e-42 146.3 0.0 2.6e-42 145.4 0.0 1.3 1 0 0 1 1 1 1 Acyl transferase domain KR PF08659.10 EGD96823.1 - 1.3e-39 136.0 0.0 1.1e-37 129.7 0.0 2.5 2 0 0 2 2 2 1 KR domain ketoacyl-synt PF00109.26 EGD96823.1 - 5.1e-38 131.1 0.0 2e-28 99.6 0.0 2.5 1 1 1 2 2 2 2 Beta-ketoacyl synthase, N-terminal domain PS-DH PF14765.6 EGD96823.1 - 4.9e-31 108.1 0.0 4.6e-26 91.8 0.0 2.3 1 1 1 2 2 2 2 Polyketide synthase dehydratase Ketoacyl-synt_C PF02801.22 EGD96823.1 - 2e-29 102.0 0.0 6e-29 100.5 0.0 1.9 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain NAD_binding_4 PF07993.12 EGD96823.1 - 1.4e-23 83.4 0.0 4.2e-22 78.6 0.0 2.5 1 1 0 1 1 1 1 Male sterility protein Methyltransf_12 PF08242.12 EGD96823.1 - 1.4e-18 67.4 0.0 3.5e-17 63.0 0.0 2.8 2 0 0 2 2 2 1 Methyltransferase domain PP-binding PF00550.25 EGD96823.1 - 5.2e-18 65.2 0.2 6e-08 32.9 0.0 3.0 2 0 0 2 2 2 2 Phosphopantetheine attachment site Methyltransf_25 PF13649.6 EGD96823.1 - 2.3e-11 44.2 0.0 1.1e-10 42.1 0.0 2.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EGD96823.1 - 1.1e-09 38.4 0.0 2.4e-09 37.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain KAsynt_C_assoc PF16197.5 EGD96823.1 - 4.3e-09 36.8 0.0 2.6e-08 34.3 0.0 2.3 2 0 0 2 2 2 1 Ketoacyl-synthetase C-terminal extension Methyltransf_31 PF13847.6 EGD96823.1 - 1.3e-08 34.8 0.0 7.5e-08 32.3 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EGD96823.1 - 2.4e-08 34.5 0.0 1.6e-07 31.9 0.0 2.5 2 0 0 2 2 2 1 Methyltransferase domain Epimerase PF01370.21 EGD96823.1 - 4.7e-07 29.5 0.0 9.1e-07 28.6 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Ubie_methyltran PF01209.18 EGD96823.1 - 2.9e-05 23.5 0.0 8.2e-05 22.0 0.0 1.7 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_16 PF10294.9 EGD96823.1 - 0.0026 17.5 0.0 0.0061 16.3 0.0 1.6 1 0 0 1 1 1 1 Lysine methyltransferase adh_short PF00106.25 EGD96823.1 - 0.0069 15.9 0.0 0.052 13.0 0.0 2.5 2 0 0 2 2 2 1 short chain dehydrogenase Methyltransf_33 PF10017.9 EGD96823.1 - 0.011 14.9 0.0 0.023 13.8 0.0 1.4 1 0 0 1 1 1 0 Histidine-specific methyltransferase, SAM-dependent AMP-binding_C PF13193.6 EGD96823.1 - 0.021 15.8 0.1 0.099 13.6 0.0 2.3 2 0 0 2 2 1 0 AMP-binding enzyme C-terminal domain Post_transc_reg PF13797.6 EGD96823.1 - 0.17 11.8 0.0 0.41 10.6 0.0 1.6 1 0 0 1 1 1 0 Post-transcriptional regulator UvdE PF03851.14 EGD96824.1 - 4.1e-109 364.1 0.0 5.2e-109 363.8 0.0 1.1 1 0 0 1 1 1 1 UV-endonuclease UvdE ADH_zinc_N PF00107.26 EGD96826.1 - 3.9e-09 36.6 0.1 8.1e-09 35.5 0.0 1.6 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EGD96826.1 - 3.7e-06 26.8 1.4 1.2e-05 25.1 1.3 1.9 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_N_2 PF16884.5 EGD96826.1 - 0.063 13.2 0.2 3.7 7.5 0.2 2.3 2 0 0 2 2 2 0 N-terminal domain of oxidoreductase ADH_zinc_N_2 PF13602.6 EGD96826.1 - 0.15 13.1 0.0 0.31 12.1 0.0 1.6 1 1 0 1 1 1 0 Zinc-binding dehydrogenase Pkinase PF00069.25 EGD96827.1 - 4.5e-64 216.3 0.0 5.5e-64 216.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD96827.1 - 5.7e-30 104.5 0.0 8.6e-30 103.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EGD96827.1 - 0.0046 15.9 0.0 0.0058 15.6 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain zf-UBR PF02207.20 EGD96828.1 - 5.2e-14 52.2 4.1 5.2e-14 52.2 4.1 3.1 4 0 0 4 4 4 1 Putative zinc finger in N-recognin (UBR box) MCM PF00493.23 EGD96829.1 - 6.6e-98 326.3 0.0 1.1e-97 325.5 0.0 1.4 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 EGD96829.1 - 2.4e-39 134.1 0.1 4.4e-39 133.2 0.1 1.4 1 0 0 1 1 1 1 MCM OB domain MCM2_N PF12619.8 EGD96829.1 - 6.7e-27 94.7 27.6 6.7e-27 94.7 27.6 1.7 2 0 0 2 2 2 1 Mini-chromosome maintenance protein 2 MCM_lid PF17855.1 EGD96829.1 - 2.9e-24 85.3 0.3 9.9e-24 83.6 0.3 2.0 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 EGD96829.1 - 7.7e-12 45.7 0.2 2.4e-11 44.1 0.2 1.9 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 EGD96829.1 - 1.3e-07 31.3 0.1 7.4e-06 25.5 0.0 2.6 2 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 EGD96829.1 - 2.6e-06 27.5 0.0 5.1e-06 26.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 EGD96829.1 - 0.0044 16.9 0.0 0.038 13.9 0.0 2.3 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 EGD96829.1 - 0.0052 16.5 0.2 0.082 12.6 0.2 2.2 1 1 0 1 1 1 1 Sigma-54 interaction domain AAA_30 PF13604.6 EGD96829.1 - 0.15 11.7 0.3 0.34 10.6 0.3 1.5 1 0 0 1 1 1 0 AAA domain VHS PF00790.19 EGD96831.1 - 1.4e-29 102.8 0.1 7.8e-29 100.3 0.0 2.1 2 0 0 2 2 2 1 VHS domain GAT PF03127.14 EGD96831.1 - 1.2e-20 73.6 0.8 1.2e-20 73.6 0.8 2.5 3 0 0 3 3 3 1 GAT domain Alpha_adaptinC2 PF02883.20 EGD96831.1 - 1.6e-12 47.7 0.2 1.6e-12 47.7 0.2 2.3 1 1 1 2 2 2 1 Adaptin C-terminal domain GGA_N-GAT PF18308.1 EGD96831.1 - 1.8e-07 30.7 1.7 1e-06 28.3 0.1 2.7 2 0 0 2 2 2 1 GGA N-GAT domain Ribo_biogen_C PF04034.13 EGD96834.1 - 3.1e-32 111.0 0.3 1.3e-24 86.3 0.0 2.2 1 1 1 2 2 2 2 Ribosome biogenesis protein, C-terminal RLI PF04068.15 EGD96834.1 - 2.1e-09 37.0 0.4 3.4e-09 36.4 0.4 1.3 1 0 0 1 1 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI Peptidase_C37 PF05416.12 EGD96834.1 - 0.012 14.1 3.6 0.018 13.6 3.6 1.2 1 0 0 1 1 1 0 Southampton virus-type processing peptidase BUD22 PF09073.10 EGD96834.1 - 0.38 10.1 13.0 0.51 9.6 13.0 1.1 1 0 0 1 1 1 0 BUD22 CDC45 PF02724.14 EGD96834.1 - 0.89 7.8 7.1 1.1 7.4 7.1 1.2 1 0 0 1 1 1 0 CDC45-like protein zf-H2C2 PF09337.10 EGD96835.1 - 1.4e-14 54.0 2.2 3.4e-14 52.8 2.2 1.7 1 0 0 1 1 1 1 H2C2 zinc finger Integrase_H2C2 PF17921.1 EGD96835.1 - 8.9e-10 38.5 0.5 8.9e-10 38.5 0.5 2.4 3 0 0 3 3 3 1 Integrase zinc binding domain Acetyltransf_1 PF00583.25 EGD96835.1 - 0.00035 20.8 0.0 0.00095 19.4 0.0 1.7 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_4 PF13420.7 EGD96835.1 - 0.017 15.2 0.0 0.032 14.4 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 EGD96835.1 - 0.15 12.7 0.0 0.33 11.6 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Cpn60_TCP1 PF00118.24 EGD96836.1 - 6.6e-107 358.2 7.0 2.2e-76 257.5 4.0 2.0 2 0 0 2 2 2 2 TCP-1/cpn60 chaperonin family Rep_fac_C PF08542.11 EGD96836.1 - 0.021 15.2 0.1 9.9 6.7 0.0 2.7 2 0 0 2 2 2 0 Replication factor C C-terminal domain Peptidase_C14 PF00656.22 EGD96837.1 - 8e-61 206.1 0.0 1e-60 205.8 0.0 1.1 1 0 0 1 1 1 1 Caspase domain F-box-like PF12937.7 EGD96839.1 - 0.0014 18.5 0.3 0.0046 16.8 0.3 1.9 1 0 0 1 1 1 1 F-box-like LRR_6 PF13516.6 EGD96839.1 - 0.024 14.7 9.3 3.6 7.9 0.1 4.6 4 0 0 4 4 4 0 Leucine Rich repeat Deltaretro_Tax PF05599.11 EGD96839.1 - 0.047 14.2 1.1 0.12 12.9 1.1 1.7 1 0 0 1 1 1 0 Deltaretrovirus Tax protein LRR_4 PF12799.7 EGD96839.1 - 0.49 10.9 15.9 0.91 10.0 0.2 5.2 5 1 0 5 5 5 0 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EGD96839.1 - 3.8 8.4 7.7 64 4.7 0.2 5.3 5 0 0 5 5 5 0 Leucine Rich Repeat Ribosomal_S26e PF01283.19 EGD96840.1 - 4.7e-51 171.7 8.2 6e-51 171.4 8.2 1.1 1 0 0 1 1 1 1 Ribosomal protein S26e zf_CopZ PF18423.1 EGD96840.1 - 0.021 14.8 0.7 0.041 13.8 0.0 1.8 2 0 0 2 2 2 0 Zinc binding domain DUF4668 PF15701.5 EGD96840.1 - 0.2 11.5 1.9 0.26 11.1 1.3 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4668) CBS PF00571.28 EGD96841.1 - 5e-35 119.7 7.2 1e-08 35.5 0.1 5.8 6 0 0 6 6 6 4 CBS domain PB1 PF00564.24 EGD96841.1 - 8.4e-11 41.7 0.1 3.8e-10 39.6 0.0 2.2 2 0 0 2 2 2 1 PB1 domain Importin_rep_4 PF18808.1 EGD96842.1 - 2.4e-33 114.3 2.8 8.5e-33 112.5 1.1 3.0 2 0 0 2 2 2 1 Importin repeat Importin_rep_5 PF18816.1 EGD96842.1 - 8.3e-23 80.5 0.3 2.7e-22 78.8 0.3 2.0 1 0 0 1 1 1 1 Importin repeat HEAT_2 PF13646.6 EGD96842.1 - 4.6e-21 75.0 2.5 0.00011 22.6 0.0 7.9 4 2 2 7 7 7 5 HEAT repeats HEAT_EZ PF13513.6 EGD96842.1 - 7.8e-20 71.0 12.0 1.3e-08 35.2 0.3 8.7 9 1 1 10 10 9 2 HEAT-like repeat HEAT PF02985.22 EGD96842.1 - 2.3e-18 64.7 5.8 0.0072 16.5 0.0 11.0 11 0 0 11 11 9 4 HEAT repeat Importin_rep_6 PF18829.1 EGD96842.1 - 4.7e-14 52.4 0.8 3e-13 49.8 0.2 2.7 2 0 0 2 2 2 1 Importin repeat 6 MMS19_C PF12460.8 EGD96842.1 - 1.1e-09 38.0 0.2 0.00013 21.2 0.1 5.0 4 1 1 5 5 5 2 RNAPII transcription regulator C-terminal Vac14_Fab1_bd PF12755.7 EGD96842.1 - 1.1e-09 38.7 0.0 0.094 13.3 0.0 6.0 3 2 2 6 6 6 2 Vacuolar 14 Fab1-binding region DUF3385 PF11865.8 EGD96842.1 - 1.8e-07 31.2 2.3 0.26 11.2 0.0 6.3 6 2 1 8 8 8 2 Domain of unknown function (DUF3385) Cnd1 PF12717.7 EGD96842.1 - 4.5e-07 30.0 0.1 0.027 14.5 0.0 4.7 4 0 0 4 4 4 1 non-SMC mitotic condensation complex subunit 1 RIX1 PF08167.12 EGD96842.1 - 1.9e-06 27.7 0.9 0.0011 18.8 0.1 4.9 4 2 0 4 4 4 1 rRNA processing/ribosome biogenesis DRIM PF07539.12 EGD96842.1 - 2.8e-06 26.0 0.8 0.03 12.6 0.1 4.3 3 2 0 4 4 4 2 Down-regulated in metastasis Arm PF00514.23 EGD96842.1 - 6.2e-06 26.1 0.4 1.3 9.1 0.1 5.0 4 0 0 4 4 4 2 Armadillo/beta-catenin-like repeat CLASP_N PF12348.8 EGD96842.1 - 1.9e-05 24.3 0.0 0.21 11.1 0.0 5.1 5 1 0 5 5 4 1 CLASP N terminal RTP1_C1 PF10363.9 EGD96842.1 - 4.6e-05 23.6 0.2 0.21 11.8 0.1 4.8 5 0 0 5 5 5 1 Required for nuclear transport of RNA pol II C-terminus 1 Adaptin_N PF01602.20 EGD96842.1 - 0.00067 18.3 1.3 0.014 14.0 0.1 3.4 3 1 0 4 4 4 1 Adaptin N terminal region IBN_N PF03810.19 EGD96842.1 - 0.0034 17.3 1.2 0.035 14.0 0.0 3.3 4 0 0 4 4 3 1 Importin-beta N-terminal domain V-ATPase_H_N PF03224.14 EGD96842.1 - 0.011 15.1 1.8 0.13 11.6 0.0 3.2 4 0 0 4 4 4 0 V-ATPase subunit H Cnd3 PF12719.7 EGD96842.1 - 0.032 13.4 1.0 3.8 6.6 0.0 4.1 3 1 0 4 4 4 0 Nuclear condensing complex subunits, C-term domain TFCD_C PF12612.8 EGD96842.1 - 0.059 13.2 0.9 19 5.0 0.0 3.9 4 0 0 4 4 4 0 Tubulin folding cofactor D C terminal DUF4042 PF13251.6 EGD96842.1 - 0.13 12.0 5.6 16 5.2 0.0 5.1 7 0 0 7 7 6 0 Domain of unknown function (DUF4042) Aconitase PF00330.20 EGD96843.1 - 8.7e-144 479.9 0.0 1.2e-143 479.5 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 EGD96843.1 - 3.4e-41 140.6 0.0 5.5e-41 140.0 0.0 1.3 1 0 0 1 1 1 1 Aconitase C-terminal domain DUF2408 PF10303.9 EGD96844.1 - 4.1e-50 169.8 0.1 2.5e-28 99.3 0.0 5.2 4 2 1 5 5 5 4 Protein of unknown function (DUF2408) CARD PF00619.21 EGD96844.1 - 0.034 14.2 0.0 0.11 12.5 0.0 1.9 1 0 0 1 1 1 0 Caspase recruitment domain PolyG_pol PF01518.16 EGD96844.1 - 0.096 11.4 0.0 0.15 10.8 0.0 1.2 1 0 0 1 1 1 0 Sigma NS protein Baculo_PEP_C PF04513.12 EGD96844.1 - 0.13 12.3 0.6 0.85 9.6 0.1 2.6 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Snapin_Pallidin PF14712.6 EGD96844.1 - 0.14 12.6 1.3 3.1 8.3 0.1 3.2 3 0 0 3 3 3 0 Snapin/Pallidin ATG16 PF08614.11 EGD96844.1 - 0.56 10.4 2.1 9 6.5 0.0 2.9 3 0 0 3 3 3 0 Autophagy protein 16 (ATG16) Ribosomal_60s PF00428.19 EGD96845.1 - 1.4e-20 73.7 6.9 2.1e-20 73.1 6.9 1.3 1 0 0 1 1 1 1 60s Acidic ribosomal protein PQ-loop PF04193.14 EGD96846.1 - 1.7e-39 133.4 4.7 8.9e-20 70.2 0.0 2.8 2 0 0 2 2 2 2 PQ loop repeat NMN_transporter PF04973.12 EGD96846.1 - 4.6 7.2 10.5 8.2 6.3 0.1 2.7 2 1 0 2 2 2 0 Nicotinamide mononucleotide transporter Tcf25 PF04910.14 EGD96847.1 - 3.1e-74 250.1 0.1 4.7e-74 249.6 0.1 1.2 1 0 0 1 1 1 1 Transcriptional repressor TCF25 DUF1754 PF08555.10 EGD96847.1 - 0.026 15.3 3.1 0.026 15.3 3.1 2.3 2 0 0 2 2 2 0 Eukaryotic family of unknown function (DUF1754) DUF1387 PF07139.11 EGD96847.1 - 0.29 10.8 7.8 0.16 11.6 2.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1387) Stm1_N PF09598.10 EGD96847.1 - 0.52 11.2 8.8 2.5 9.0 8.8 2.2 1 1 0 1 1 1 0 Stm1 DUF3381 PF11861.8 EGD96847.1 - 4.1 7.2 8.4 7 6.4 8.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3381) PP2C PF00481.21 EGD96848.1 - 1.8e-41 142.5 0.0 2.9e-41 141.8 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.6 EGD96848.1 - 0.0003 20.5 0.0 0.00049 19.8 0.0 1.4 1 0 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 EGD96848.1 - 0.025 14.5 0.0 0.67 9.8 0.0 2.6 3 0 0 3 3 3 0 Stage II sporulation protein E (SpoIIE) PPDFL PF15060.6 EGD96848.1 - 1.4 9.5 7.3 9.6 6.8 0.0 2.9 2 1 0 2 2 2 0 Differentiation and proliferation regulator 60KD_IMP PF02096.20 EGD96849.1 - 3.4e-14 53.1 0.2 4.2e-14 52.8 0.2 1.1 1 0 0 1 1 1 1 60Kd inner membrane protein Antimicrobial19 PF08225.11 EGD96849.1 - 0.15 11.7 1.9 1.6 8.4 0.2 2.3 2 0 0 2 2 2 0 Pseudin antimicrobial peptide ALG11_N PF15924.5 EGD96850.1 - 1e-46 159.6 0.0 1.4e-46 159.2 0.0 1.1 1 0 0 1 1 1 1 ALG11 mannosyltransferase N-terminus HemY_N PF07219.13 EGD96850.1 - 0.0077 16.4 0.4 0.023 14.9 0.4 1.7 1 0 0 1 1 1 1 HemY protein N-terminus DUF4179 PF13786.6 EGD96850.1 - 0.13 12.8 0.0 0.33 11.4 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4179) ArenaCapSnatch PF17296.2 EGD96851.1 - 0.12 11.8 0.0 0.12 11.8 0.0 1.1 1 0 0 1 1 1 0 Arenavirus cap snatching domain Methyltransf_23 PF13489.6 EGD96853.1 - 9.1e-17 61.4 0.0 1.2e-16 61.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EGD96853.1 - 1.1e-08 35.7 0.0 3.5e-08 34.0 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EGD96853.1 - 1.4e-05 25.6 0.0 5.1e-05 23.8 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EGD96853.1 - 4.2e-05 23.4 0.0 0.0001 22.1 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_4 PF02390.17 EGD96853.1 - 0.00017 21.1 0.0 0.00039 19.9 0.0 1.6 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_12 PF08242.12 EGD96853.1 - 0.00031 21.4 0.0 0.00095 19.9 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EGD96853.1 - 0.0009 18.8 0.0 0.0016 18.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain FtsJ PF01728.19 EGD96853.1 - 0.0011 19.1 0.0 0.0018 18.4 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase PrmA PF06325.13 EGD96853.1 - 0.0055 16.1 0.0 0.0084 15.5 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_2 PF00891.18 EGD96853.1 - 0.013 14.8 0.0 0.022 14.1 0.0 1.3 1 0 0 1 1 1 0 O-methyltransferase domain Methyltransf_16 PF10294.9 EGD96853.1 - 0.019 14.7 0.0 0.03 14.1 0.0 1.2 1 0 0 1 1 1 0 Lysine methyltransferase CMAS PF02353.20 EGD96853.1 - 0.079 12.2 0.0 0.2 10.9 0.0 1.6 2 0 0 2 2 2 0 Mycolic acid cyclopropane synthetase Ubie_methyltran PF01209.18 EGD96853.1 - 0.082 12.2 0.0 0.48 9.7 0.0 2.1 3 0 0 3 3 3 0 ubiE/COQ5 methyltransferase family WD40 PF00400.32 EGD96854.1 - 6.9e-16 58.3 10.5 2.4e-06 28.2 0.5 5.6 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EGD96854.1 - 3.4e-11 43.3 1.3 0.006 16.9 0.0 4.3 3 2 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EGD96854.1 - 8.3e-05 22.6 0.1 0.78 9.6 0.0 2.9 3 0 0 3 3 3 2 Eukaryotic translation initiation factor eIF2A Cytochrom_D1 PF02239.16 EGD96854.1 - 0.11 10.9 0.0 0.21 10.1 0.0 1.5 1 0 0 1 1 1 0 Cytochrome D1 heme domain RNA_pol_Rpb1_1 PF04997.12 EGD96855.1 - 3.2e-112 374.9 0.0 5.7e-112 374.1 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_2 PF00623.20 EGD96855.1 - 2.8e-74 248.8 0.0 5.6e-74 247.9 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_5 PF04998.17 EGD96855.1 - 5.6e-73 245.7 0.0 1e-72 244.8 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_6 PF04992.14 EGD96855.1 - 2.2e-65 220.1 1.4 4.1e-65 219.2 1.4 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 6 RNA_pol_Rpb1_7 PF04990.12 EGD96855.1 - 9.8e-40 135.7 9.1 1.1e-36 125.7 7.2 3.1 2 1 0 2 2 2 1 RNA polymerase Rpb1, domain 7 RNA_pol_Rpb1_4 PF05000.17 EGD96855.1 - 7.4e-38 128.8 0.2 1.5e-37 127.8 0.2 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_3 PF04983.18 EGD96855.1 - 7.3e-28 97.5 0.0 1.7e-26 93.0 0.0 2.6 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_R PF05001.13 EGD96855.1 - 2.2e-17 62.4 200.0 0.01 16.2 1.4 14.3 12 1 1 13 13 13 10 RNA polymerase Rpb1 C-terminal repeat Thg1 PF04446.12 EGD96857.1 - 8.5e-55 184.1 0.1 1.4e-54 183.4 0.1 1.4 1 0 0 1 1 1 1 tRNAHis guanylyltransferase Thg1C PF14413.6 EGD96857.1 - 5e-51 172.0 2.8 6.8e-51 171.5 2.8 1.2 1 0 0 1 1 1 1 Thg1 C terminal domain fn3 PF00041.21 EGD96858.1 - 0.00068 19.9 0.0 0.0018 18.6 0.0 1.7 1 0 0 1 1 1 1 Fibronectin type III domain DUF4407 PF14362.6 EGD96858.1 - 0.39 10.0 27.9 0.14 11.5 24.7 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Snapin_Pallidin PF14712.6 EGD96858.1 - 1.6 9.2 26.5 3.6 8.1 2.4 3.3 2 1 1 3 3 3 0 Snapin/Pallidin T3SSipB PF16535.5 EGD96858.1 - 2.9 8.4 17.2 2.7 8.5 15.1 1.9 1 1 1 2 2 2 0 Type III cell invasion protein SipB Leu_zip PF15294.6 EGD96858.1 - 7.5 6.0 33.6 3.1 7.2 30.7 1.7 1 1 1 2 2 2 0 Leucine zipper LNS2 PF08235.13 EGD96859.1 - 4.8e-95 317.3 0.0 6.8e-95 316.8 0.0 1.2 1 0 0 1 1 1 1 LNS2 (Lipin/Ned1/Smp2) Lipin_N PF04571.14 EGD96859.1 - 7.2e-43 144.7 0.0 1.5e-42 143.7 0.0 1.5 1 0 0 1 1 1 1 lipin, N-terminal conserved region Acid_phosphat_B PF03767.14 EGD96859.1 - 0.026 14.1 0.0 0.26 10.8 0.0 2.5 3 0 0 3 3 3 0 HAD superfamily, subfamily IIIB (Acid phosphatase) TFIID-31kDa PF02291.15 EGD96860.1 - 5.6e-45 152.4 0.0 7.5e-45 151.9 0.0 1.2 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Cmc1 PF08583.10 EGD96861.1 - 5.5e-12 45.5 4.1 1.5e-11 44.2 4.1 1.9 1 1 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like Utp11 PF03998.13 EGD96862.1 - 2.8e-57 194.5 28.8 3.2e-57 194.3 28.8 1.0 1 0 0 1 1 1 1 Utp11 protein GCIP PF13324.6 EGD96862.1 - 0.6 9.7 6.5 0.83 9.2 6.5 1.2 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting Histidinol_dh PF00815.20 EGD96863.1 - 3.2e-160 533.6 4.8 4.7e-160 533.1 4.8 1.3 1 0 0 1 1 1 1 Histidinol dehydrogenase PRA-CH PF01502.18 EGD96863.1 - 6.8e-24 83.5 0.1 1.4e-23 82.5 0.1 1.5 1 0 0 1 1 1 1 Phosphoribosyl-AMP cyclohydrolase PRA-PH PF01503.17 EGD96863.1 - 1.4e-14 54.3 0.0 5.5e-14 52.4 0.0 2.1 1 0 0 1 1 1 1 Phosphoribosyl-ATP pyrophosphohydrolase MazG PF03819.17 EGD96863.1 - 0.12 12.6 0.2 0.32 11.2 0.2 1.8 1 0 0 1 1 1 0 MazG nucleotide pyrophosphohydrolase domain Glyco_hydro_47 PF01532.20 EGD96865.1 - 2e-142 475.3 0.0 2.3e-142 475.1 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 VIT1 PF01988.19 EGD96866.1 - 0.011 15.6 1.4 0.024 14.5 1.4 1.5 1 0 0 1 1 1 0 VIT family Acetyltransf_3 PF13302.7 EGD96867.1 - 4.9e-17 62.9 0.0 8.8e-17 62.1 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EGD96867.1 - 1.3e-09 38.3 0.0 2.5e-09 37.4 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.10 EGD96867.1 - 0.00021 21.2 0.0 0.00039 20.3 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_10 PF13673.7 EGD96867.1 - 0.062 13.2 0.0 0.47 10.4 0.0 2.0 1 1 0 2 2 2 0 Acetyltransferase (GNAT) domain AA_permease_2 PF13520.6 EGD96868.1 - 2.9e-41 141.7 46.5 3.8e-41 141.3 46.5 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EGD96868.1 - 5e-22 78.1 43.2 3.3e-21 75.5 43.2 1.9 1 1 0 1 1 1 1 Amino acid permease YlaH PF14036.6 EGD96868.1 - 0.0002 21.6 1.7 0.00096 19.4 1.7 2.2 1 0 0 1 1 1 1 YlaH-like protein CBM_19 PF03427.13 EGD96868.1 - 0.082 12.9 0.6 0.24 11.4 0.6 1.8 1 0 0 1 1 1 0 Carbohydrate binding domain (family 19) Acetyltransf_7 PF13508.7 EGD96871.1 - 6.6e-09 36.1 0.0 1e-08 35.4 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EGD96871.1 - 1.9e-08 34.3 0.0 3e-08 33.6 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EGD96871.1 - 2.1e-07 31.2 0.0 4e-07 30.3 0.0 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.10 EGD96871.1 - 2.4e-05 24.2 0.0 4.4e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.7 EGD96871.1 - 0.0032 17.6 0.5 0.34 11.0 0.0 2.5 2 1 1 3 3 3 1 Acetyltransferase (GNAT) domain CDC45 PF02724.14 EGD96872.1 - 8e-239 794.2 0.0 5e-238 791.6 0.0 2.6 1 1 0 1 1 1 1 CDC45-like protein BUD22 PF09073.10 EGD96872.1 - 0.1 12.0 26.7 0.19 11.0 10.8 2.1 2 0 0 2 2 2 0 BUD22 FAM60A PF15396.6 EGD96872.1 - 1.6 8.7 6.2 0.18 11.8 1.3 1.8 2 0 0 2 2 2 0 Protein Family FAM60A CSRNP_N PF16019.5 EGD96872.1 - 2.9 7.7 6.1 6.4 6.6 6.1 1.5 1 0 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus Med5 PF08689.10 EGD96872.1 - 4.5 5.0 4.9 6.3 4.5 4.9 1.1 1 0 0 1 1 1 0 Mediator complex subunit Med5 Peptidase_C13 PF01650.18 EGD96873.1 - 5.2e-41 140.9 0.0 8.4e-41 140.2 0.0 1.3 1 0 0 1 1 1 1 Peptidase C13 family F-box-like PF12937.7 EGD96874.1 - 4.6e-07 29.6 0.3 9.2e-07 28.7 0.3 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EGD96874.1 - 1.8e-06 27.7 0.6 1.8e-06 27.7 0.6 2.8 3 0 0 3 3 3 1 F-box domain F-box_4 PF15966.5 EGD96874.1 - 0.0018 18.1 0.1 0.0044 16.9 0.1 1.7 1 0 0 1 1 1 1 F-box Ccdc124 PF06244.12 EGD96875.1 - 9.6e-28 97.3 26.4 9.6e-28 97.3 26.4 2.4 2 1 0 2 2 2 1 Coiled-coil domain-containing protein 124 /Oxs1 WD40 PF00400.32 EGD96876.1 - 5.1e-15 55.6 14.9 0.012 16.5 0.1 6.3 6 0 0 6 6 6 6 WD domain, G-beta repeat Abhydrolase_6 PF12697.7 EGD96877.1 - 6.5e-16 59.6 5.5 3.3e-15 57.3 5.5 1.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EGD96877.1 - 0.017 14.8 0.0 0.034 13.8 0.0 1.5 1 1 0 1 1 1 0 alpha/beta hydrolase fold MFS_1 PF07690.16 EGD96878.1 - 5.3e-36 124.3 10.3 2e-34 119.1 10.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EGD96878.1 - 3.9e-10 39.2 0.9 8.4e-10 38.1 0.9 1.5 1 0 0 1 1 1 1 Sugar (and other) transporter DHHC PF01529.20 EGD96880.1 - 2.8e-36 124.6 12.9 2.8e-36 124.6 12.9 1.6 2 0 0 2 2 2 1 DHHC palmitoyltransferase UQ_con PF00179.26 EGD96881.1 - 7.2e-19 67.8 0.0 1.1e-18 67.3 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 EGD96881.1 - 0.019 15.3 0.0 0.041 14.2 0.0 1.5 1 0 0 1 1 1 0 RWD domain B-block_TFIIIC PF04182.12 EGD96882.1 - 2.6e-21 75.5 0.1 5.8e-21 74.4 0.1 1.6 1 0 0 1 1 1 1 B-block binding subunit of TFIIIC MarR_2 PF12802.7 EGD96882.1 - 0.076 12.9 0.1 0.076 12.9 0.1 3.0 3 0 0 3 3 3 0 MarR family HTH_36 PF13730.6 EGD96882.1 - 0.13 12.3 0.0 0.37 10.8 0.0 1.8 1 0 0 1 1 1 0 Helix-turn-helix domain Apt1 PF10351.9 EGD96884.1 - 2.1e-181 604.0 0.0 2.1e-181 604.0 0.0 2.7 4 0 0 4 4 4 1 Golgi-body localisation protein domain Fmp27 PF10344.9 EGD96884.1 - 5.5e-171 570.7 0.0 9.8e-171 569.9 0.0 1.4 1 0 0 1 1 1 1 Mitochondrial protein from FMP27 Fmp27_WPPW PF10359.9 EGD96884.1 - 2.1e-147 491.9 6.1 3.5e-147 491.2 6.1 1.3 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain Fmp27_GFWDK PF10347.9 EGD96884.1 - 1.6e-55 187.5 0.1 4.4e-55 186.1 0.0 1.8 2 0 0 2 2 2 1 RNA pol II promoter Fmp27 protein domain DUF2405 PF10293.9 EGD96884.1 - 1.3e-51 174.6 0.0 3.7e-51 173.1 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF2405) Fmp27_SW PF10305.9 EGD96884.1 - 1e-27 96.8 0.0 6.8e-27 94.2 0.0 2.6 2 0 0 2 2 2 1 RNA pol II promoter Fmp27 protein domain KRE1 PF17056.5 EGD96885.1 - 1.6e-06 27.7 0.1 3.3e-06 26.7 0.1 1.5 1 1 0 1 1 1 1 Killer toxin-resistance protein 1 RNA_pol_Rpc4 PF05132.14 EGD96886.1 - 5.3e-33 114.5 0.1 5.3e-33 114.5 0.1 3.4 1 1 1 2 2 2 1 RNA polymerase III RPC4 Pkinase PF00069.25 EGD96887.1 - 9.5e-07 28.4 0.4 0.0002 20.8 0.0 2.5 3 0 0 3 3 3 2 Protein kinase domain HTH_33 PF13592.6 EGD96887.1 - 2.7e-06 26.9 0.0 1.1e-05 25.0 0.0 1.9 2 0 0 2 2 2 1 Winged helix-turn helix HTH_32 PF13565.6 EGD96887.1 - 0.00021 21.9 3.9 0.027 15.1 0.0 3.5 3 0 0 3 3 3 2 Homeodomain-like domain Pkinase_Tyr PF07714.17 EGD96887.1 - 0.0012 18.2 0.2 0.04 13.2 0.0 2.3 2 0 0 2 2 2 1 Protein tyrosine kinase Kdo PF06293.14 EGD96887.1 - 0.057 12.8 0.0 0.14 11.5 0.0 1.6 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Zn_clus PF00172.18 EGD96888.1 - 0.00079 19.5 12.6 0.0017 18.5 12.6 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF4349 PF14257.6 EGD96888.1 - 0.023 14.1 0.1 0.023 14.1 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4349) CHZ PF09649.10 EGD96888.1 - 0.36 10.3 0.0 0.36 10.3 0.0 2.3 3 0 0 3 3 3 0 Histone chaperone domain CHZ Cyclin_N PF00134.23 EGD96891.1 - 8.4e-45 151.6 0.4 1.5e-44 150.8 0.4 1.5 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 EGD96891.1 - 1.8e-23 82.9 3.8 6.4e-23 81.1 0.0 3.3 3 1 1 4 4 4 2 Cyclin, C-terminal domain THEG4 PF15834.5 EGD96891.1 - 9 6.2 9.9 21 5.0 9.9 1.6 1 0 0 1 1 1 0 Testis highly expressed protein 4 zf-C2HE PF16278.5 EGD96892.1 - 3.9e-21 75.3 0.7 3.9e-21 75.3 0.7 1.9 2 0 0 2 2 2 1 C2HE / C2H2 / C2HC zinc-binding finger DcpS_C PF11969.8 EGD96892.1 - 6.4e-16 58.8 0.1 1.5e-07 31.9 0.1 2.2 2 0 0 2 2 2 2 Scavenger mRNA decapping enzyme C-term binding HIT PF01230.23 EGD96892.1 - 1.3e-12 48.3 1.4 4.3e-12 46.6 1.4 1.8 1 1 0 1 1 1 1 HIT domain 2-Hacid_dh_C PF02826.19 EGD96893.1 - 1.4e-54 184.2 0.0 1.8e-54 183.8 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EGD96893.1 - 1.2e-17 63.8 0.0 1.6e-17 63.5 0.0 1.0 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 EGD96893.1 - 7.3e-07 29.5 0.0 1.1e-06 28.9 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase GFO_IDH_MocA PF01408.22 EGD96893.1 - 0.0013 19.5 0.0 0.0049 17.7 0.0 2.0 2 0 0 2 2 2 1 Oxidoreductase family, NAD-binding Rossmann fold F420_oxidored PF03807.17 EGD96893.1 - 0.0061 17.1 0.0 0.012 16.1 0.0 1.5 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent XH PF03469.14 EGD96894.1 - 0.039 13.8 0.1 0.056 13.4 0.1 1.2 1 0 0 1 1 1 0 XH domain RRM_1 PF00076.22 EGD96895.1 - 3.5e-15 55.6 0.0 6.8e-15 54.6 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Sec2p PF06428.11 EGD96896.1 - 3.6e-10 39.7 13.7 3.6e-10 39.7 13.7 2.1 2 1 0 2 2 2 1 GDP/GTP exchange factor Sec2p ATG16 PF08614.11 EGD96896.1 - 0.0097 16.1 35.4 0.016 15.4 14.6 2.1 2 0 0 2 2 2 2 Autophagy protein 16 (ATG16) DUF4795 PF16043.5 EGD96896.1 - 0.032 13.8 7.1 0.11 12.1 2.4 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4795) SlyX PF04102.12 EGD96896.1 - 0.083 13.5 1.3 0.083 13.5 1.3 3.6 3 1 0 3 3 3 0 SlyX DUF4407 PF14362.6 EGD96896.1 - 1.7 8.0 17.5 0.48 9.7 2.7 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) DUF2072 PF09845.9 EGD96896.1 - 1.9 8.7 8.9 1.8 8.8 0.5 2.3 2 1 0 2 2 2 0 Zn-ribbon containing protein Spc7 PF08317.11 EGD96896.1 - 2.2 7.1 17.6 0.58 9.0 8.2 2.1 2 0 0 2 2 2 0 Spc7 kinetochore protein Ribosomal_L32e PF01655.18 EGD96897.1 - 9.5e-49 164.3 0.5 9.5e-49 164.3 0.5 1.4 1 1 1 2 2 2 1 Ribosomal protein L32 PseudoU_synth_2 PF00849.22 EGD96898.1 - 1.4e-24 87.0 0.0 2.1e-24 86.4 0.0 1.3 1 0 0 1 1 1 1 RNA pseudouridylate synthase S4 PF01479.25 EGD96898.1 - 0.097 12.4 0.1 0.17 11.6 0.1 1.4 1 0 0 1 1 1 0 S4 domain Glyco_tran_WecB PF03808.13 EGD96898.1 - 0.1 12.5 0.0 0.2 11.6 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase WecB/TagA/CpsF family 4HBT PF03061.22 EGD96899.1 - 1.2e-07 31.9 0.0 1.8e-07 31.4 0.0 1.3 1 0 0 1 1 1 1 Thioesterase superfamily Acyl-ACP_TE PF01643.17 EGD96899.1 - 0.00021 20.7 0.2 0.0003 20.2 0.2 1.2 1 0 0 1 1 1 1 Acyl-ACP thioesterase 4HBT_2 PF13279.6 EGD96899.1 - 0.0012 19.3 0.0 0.0016 18.9 0.0 1.1 1 0 0 1 1 1 1 Thioesterase-like superfamily DnaJ_C PF01556.18 EGD96900.1 - 8e-39 133.1 0.5 1.4e-38 132.3 0.5 1.3 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 EGD96900.1 - 5e-22 77.8 4.3 9e-22 77.0 4.3 1.4 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 EGD96900.1 - 3.7e-13 49.6 19.2 6.7e-13 48.8 19.2 1.5 1 0 0 1 1 1 1 DnaJ central domain PHD_4 PF16866.5 EGD96900.1 - 9.7 6.4 8.4 0.66 10.1 0.7 2.7 2 1 1 3 3 3 0 PHD-finger tRNA-synt_1c PF00749.21 EGD96901.1 - 6.6e-93 311.0 0.0 1.2e-92 310.2 0.0 1.4 2 0 0 2 2 2 1 tRNA synthetases class I (E and Q), catalytic domain MAP65_ASE1 PF03999.12 EGD96902.1 - 1.2e-68 232.3 38.1 1.7e-67 228.5 32.6 2.8 1 1 1 2 2 2 2 Microtubule associated protein (MAP65/ASE1 family) Seryl_tRNA_N PF02403.22 EGD96902.1 - 0.36 11.1 13.8 5.2 7.3 0.1 4.5 5 0 0 5 5 5 0 Seryl-tRNA synthetase N-terminal domain DUF5101 PF17031.5 EGD96902.1 - 0.46 10.6 3.0 0.34 11.0 0.7 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF5101) CC2-LZ PF16516.5 EGD96902.1 - 0.52 10.7 13.4 1.5 9.2 0.7 4.0 2 2 1 3 3 3 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator Occludin_ELL PF07303.13 EGD96902.1 - 0.83 10.4 4.0 4.4 8.1 0.0 3.6 2 2 0 2 2 2 0 Occludin homology domain TMF_TATA_bd PF12325.8 EGD96902.1 - 0.85 9.9 19.9 0.19 11.9 2.2 4.1 4 1 0 4 4 4 0 TATA element modulatory factor 1 TATA binding RmuC PF02646.16 EGD96902.1 - 1.3 8.0 6.0 7.9 5.5 0.2 2.8 3 0 0 3 3 3 0 RmuC family DUF4795 PF16043.5 EGD96902.1 - 6.1 6.4 9.6 9.7 5.7 1.7 2.9 2 2 1 3 3 3 0 Domain of unknown function (DUF4795) Spectrin PF00435.21 EGD96902.1 - 7.4 7.1 12.0 2.2 8.8 0.5 3.9 3 1 1 4 4 4 0 Spectrin repeat Pkinase PF00069.25 EGD96903.1 - 3.6e-22 79.0 0.0 4.5e-22 78.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD96903.1 - 1.9e-17 63.4 0.0 3.7e-17 62.5 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EGD96903.1 - 0.00016 21.1 0.1 0.00025 20.5 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 EGD96903.1 - 0.024 14.2 0.0 0.063 12.9 0.0 1.5 1 1 0 1 1 1 0 Choline/ethanolamine kinase JAB PF01398.21 EGD96904.1 - 2.1e-29 101.9 0.0 3.8e-29 101.1 0.0 1.5 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease CSN5_C PF18323.1 EGD96904.1 - 1.2e-24 87.0 0.0 2.3e-24 86.1 0.0 1.5 1 0 0 1 1 1 1 Cop9 signalosome subunit 5 C-terminal domain Prok-JAB PF14464.6 EGD96904.1 - 0.0012 18.6 0.0 0.0028 17.4 0.0 1.6 2 0 0 2 2 2 1 Prokaryotic homologs of the JAB domain SRP1_TIP1 PF00660.17 EGD96904.1 - 0.096 12.8 0.1 0.25 11.4 0.1 1.7 1 0 0 1 1 1 0 Seripauperin and TIP1 family DUF4234 PF14018.6 EGD96905.1 - 0.024 14.7 0.0 0.037 14.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4234) PAP_PilO PF06864.12 EGD96905.1 - 0.087 11.6 0.1 0.1 11.4 0.1 1.1 1 0 0 1 1 1 0 Pilin accessory protein (PilO) DUF1418 PF07214.12 EGD96905.1 - 0.17 11.7 0.0 0.23 11.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1418) CRCB PF02537.15 EGD96906.1 - 1e-39 134.7 12.0 2.2e-23 82.4 5.7 2.4 2 0 0 2 2 2 2 CrcB-like protein, Camphor Resistance (CrcB) Prion_bPrPp PF11587.8 EGD96906.1 - 3.5 7.5 6.0 2.5 8.0 1.7 2.5 2 0 0 2 2 2 0 Major prion protein bPrPp - N terminal UPRTase PF14681.6 EGD96907.1 - 4.2e-70 235.4 0.0 4.9e-70 235.2 0.0 1.0 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Pribosyltran PF00156.27 EGD96907.1 - 8.2e-07 28.7 0.0 1.2e-06 28.1 0.0 1.4 1 1 0 1 1 1 1 Phosphoribosyl transferase domain Fungal_trans PF04082.18 EGD96909.1 - 2.5e-19 69.4 3.3 4.7e-19 68.5 3.3 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-H2C2_2 PF13465.6 EGD96909.1 - 4.6e-07 30.0 13.8 8.1e-05 22.9 5.5 2.9 2 0 0 2 2 2 2 Zinc-finger double domain Mucin PF01456.17 EGD96909.1 - 0.0031 17.5 9.3 0.0098 15.9 9.3 1.8 1 0 0 1 1 1 1 Mucin-like glycoprotein zf-C2H2 PF00096.26 EGD96909.1 - 0.016 15.7 18.3 0.28 11.7 7.6 3.2 3 0 0 3 3 3 0 Zinc finger, C2H2 type zf-C2H2_3rep PF18868.1 EGD96909.1 - 2.1 9.0 6.3 2.3 8.9 0.0 3.0 2 1 1 3 3 3 0 Zinc finger C2H2-type, 3 repeats Suf PF05843.14 EGD96909.1 - 7.5 6.4 6.7 17 5.3 6.7 1.7 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) RasGEF PF00617.19 EGD96910.1 - 1.6e-60 204.4 0.1 2.7e-60 203.6 0.1 1.4 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 EGD96910.1 - 7.1e-26 90.5 0.1 1.6e-25 89.4 0.1 1.6 1 0 0 1 1 1 1 RasGEF N-terminal motif SH3_1 PF00018.28 EGD96910.1 - 7.7e-13 47.8 0.1 1.4e-12 47.0 0.1 1.5 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 EGD96910.1 - 8.1e-11 41.4 0.1 2.1e-10 40.1 0.1 1.8 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 EGD96910.1 - 9.4e-11 41.4 0.1 2.1e-10 40.3 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain WW PF00397.26 EGD96910.1 - 0.018 15.1 1.7 0.021 14.9 0.0 2.1 2 0 0 2 2 2 0 WW domain RHH_1 PF01402.21 EGD96910.1 - 0.057 13.4 0.7 0.2 11.6 0.7 2.0 1 0 0 1 1 1 0 Ribbon-helix-helix protein, copG family Arylsulfotran_2 PF14269.6 EGD96911.1 - 1.6e-111 372.5 0.4 2.3e-111 372.0 0.4 1.2 1 0 0 1 1 1 1 Arylsulfotransferase (ASST) Arylsulfotrans PF05935.11 EGD96911.1 - 6.3e-16 58.3 0.1 2e-14 53.3 0.1 2.2 1 1 0 1 1 1 1 Arylsulfotransferase (ASST) Pkinase PF00069.25 EGD96912.1 - 3e-33 115.3 0.0 7e-33 114.1 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD96912.1 - 4.4e-11 42.6 0.0 1.4e-09 37.6 0.0 2.5 1 1 0 1 1 1 1 Protein tyrosine kinase SIS PF01380.22 EGD96914.1 - 6.6e-52 174.8 0.1 3.5e-31 107.8 0.0 2.3 2 0 0 2 2 2 2 SIS domain GATase_6 PF13522.6 EGD96914.1 - 1.2e-17 64.4 0.0 2.2e-17 63.5 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.6 EGD96914.1 - 5.6e-11 42.4 0.0 1.1e-10 41.4 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_4 PF13230.6 EGD96914.1 - 0.00019 20.4 0.0 0.00031 19.7 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferases class-II SIS_2 PF13580.6 EGD96914.1 - 0.027 14.5 0.0 1.9 8.5 0.0 2.6 2 0 0 2 2 2 0 SIS domain N-SET PF11764.8 EGD96915.1 - 1.6e-58 197.6 0.3 1.6e-58 197.6 0.3 2.4 2 0 0 2 2 2 1 COMPASS (Complex proteins associated with Set1p) component N SET_assoc PF11767.8 EGD96915.1 - 2.3e-27 94.4 0.3 5.9e-27 93.1 0.3 1.8 1 0 0 1 1 1 1 Histone lysine methyltransferase SET associated SET PF00856.28 EGD96915.1 - 8.9e-20 71.8 0.2 8.9e-20 71.8 0.2 3.4 3 0 0 3 3 3 1 SET domain RRM_1 PF00076.22 EGD96915.1 - 0.0005 19.8 0.0 0.0012 18.6 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Trm112p PF03966.16 EGD96916.1 - 5.9e-15 55.6 0.1 7.3e-15 55.3 0.1 1.1 1 0 0 1 1 1 1 Trm112p-like protein Rad60-SLD PF11976.8 EGD96917.1 - 9.9e-24 83.0 1.1 2.4e-19 68.9 0.7 2.4 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 EGD96917.1 - 4.4e-05 23.1 0.4 0.0063 16.2 0.1 2.3 2 0 0 2 2 2 2 Ubiquitin family Rxt3 PF08642.10 EGD96917.1 - 3.2 8.5 12.3 0.88 10.4 0.6 3.0 3 1 0 3 3 3 0 Histone deacetylation protein Rxt3 LSM PF01423.22 EGD96918.1 - 9.1e-20 70.1 0.0 1e-19 70.0 0.0 1.0 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EGD96918.1 - 0.0022 18.1 0.1 0.0026 17.9 0.1 1.1 1 0 0 1 1 1 1 Ataxin 2 SM domain LSM14 PF12701.7 EGD96918.1 - 0.032 14.3 0.1 0.037 14.1 0.1 1.1 1 0 0 1 1 1 0 Scd6-like Sm domain Hfq PF17209.3 EGD96918.1 - 0.09 12.4 0.0 0.12 12.1 0.0 1.2 1 0 0 1 1 1 0 Hfq protein DUF1106 PF06523.11 EGD96918.1 - 0.13 12.3 0.0 0.15 12.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1106) IF-2B PF01008.17 EGD96919.1 - 5.4e-70 235.8 0.7 6.3e-70 235.6 0.7 1.0 1 0 0 1 1 1 1 Initiation factor 2 subunit family KxDL PF10241.9 EGD96920.1 - 0.018 15.3 0.2 0.03 14.6 0.2 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein DUF4446 PF14584.6 EGD96920.1 - 0.36 10.8 3.1 0.15 12.0 0.3 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF4446) Pkinase PF00069.25 EGD96921.1 - 3.5e-14 52.8 0.0 6.7e-14 51.9 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD96921.1 - 3.4e-11 42.9 0.0 7.9e-11 41.7 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EGD96921.1 - 9.6e-05 21.8 0.0 0.00013 21.4 0.0 1.1 1 0 0 1 1 1 1 Kinase-like GST_C PF00043.25 EGD96922.1 - 2.8e-14 53.1 0.0 1.2e-13 51.1 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EGD96922.1 - 9.4e-14 51.5 0.0 1.6e-13 50.8 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 EGD96922.1 - 8.6e-13 48.5 0.0 1.4e-12 47.8 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EGD96922.1 - 8.7e-09 35.5 0.0 1.6e-08 34.6 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 EGD96922.1 - 1.9e-08 34.5 0.0 7.1e-08 32.7 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EGD96922.1 - 2.2e-08 34.0 0.1 4.4e-08 33.0 0.1 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain RAMP4 PF06624.12 EGD96924.1 - 3.7e-13 49.3 0.1 4.7e-13 49.0 0.1 1.1 1 0 0 1 1 1 1 Ribosome associated membrane protein RAMP4 Adaptin_N PF01602.20 EGD96925.1 - 1.2e-79 268.3 0.0 2.3e-79 267.3 0.0 1.5 1 1 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 EGD96925.1 - 1.1e-06 28.8 0.0 0.0022 18.1 0.0 2.3 2 0 0 2 2 2 2 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 EGD96925.1 - 0.013 15.7 0.2 20 5.8 0.0 4.3 4 0 0 4 4 4 0 HEAT repeat TPR_14 PF13428.6 EGD96926.1 - 2.1e-08 34.3 3.2 0.026 15.3 0.0 4.8 2 2 2 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 EGD96926.1 - 7.5e-07 29.6 0.7 0.054 14.0 0.0 3.5 2 1 2 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 EGD96926.1 - 5.1e-06 26.3 0.0 0.0062 16.7 0.0 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.6 EGD96926.1 - 4e-05 23.7 0.0 0.14 12.6 0.0 3.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 EGD96926.1 - 9.2e-05 22.3 1.1 0.037 14.2 0.0 4.2 5 1 0 5 5 5 1 Tetratricopeptide repeat Wzy_C_2 PF11846.8 EGD96926.1 - 0.00083 19.3 0.0 0.16 11.9 0.0 2.3 1 1 1 2 2 2 1 Virulence factor membrane-bound polymerase, C-terminal TPR_11 PF13414.6 EGD96926.1 - 0.013 15.2 0.1 2.6 7.8 0.1 3.5 2 1 1 3 3 3 0 TPR repeat TPR_16 PF13432.6 EGD96926.1 - 0.018 15.7 1.1 2.3 9.0 0.0 3.7 3 1 0 4 4 4 0 Tetratricopeptide repeat TPR_1 PF00515.28 EGD96926.1 - 0.035 13.9 0.0 0.48 10.3 0.0 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF615 PF04751.14 EGD96926.1 - 0.056 13.4 0.2 0.31 11.0 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF615) TPR_9 PF13371.6 EGD96926.1 - 0.13 12.4 0.8 0.32 11.2 0.1 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_12 PF13424.6 EGD96926.1 - 0.13 12.5 3.2 17 5.8 0.1 4.0 4 1 0 4 4 4 0 Tetratricopeptide repeat RNA_pol_3_Rpc31 PF11705.8 EGD96927.1 - 0.00016 22.0 0.6 0.00016 22.0 0.6 3.0 2 1 0 2 2 2 1 DNA-directed RNA polymerase III subunit Rpc31 BAF1_ABF1 PF04684.13 EGD96927.1 - 0.33 10.0 6.2 0.03 13.4 1.1 1.7 2 0 0 2 2 2 0 BAF1 / ABF1 chromatin reorganising factor Spem1 PF15670.5 EGD96927.1 - 2.2 7.8 8.4 6.5 6.3 8.4 1.7 1 0 0 1 1 1 0 Spermatid maturation protein 1 Kinesin PF00225.23 EGD96929.1 - 5.1e-96 321.5 0.1 9.8e-96 320.6 0.1 1.4 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EGD96929.1 - 2.7e-23 82.6 0.2 2.2e-21 76.4 0.0 2.6 3 0 0 3 3 3 1 Microtubule binding Cytochrom_B562 PF07361.11 EGD96929.1 - 0.0079 16.8 0.8 0.06 14.0 0.0 2.7 2 0 0 2 2 2 1 Cytochrome b562 GNAT_acetyltr_2 PF13718.6 EGD96929.1 - 0.02 14.3 0.8 1 8.7 0.4 2.4 2 0 0 2 2 2 0 GNAT acetyltransferase 2 MoCF_biosynth PF00994.24 EGD96929.1 - 0.046 13.4 0.1 0.25 11.0 0.0 2.3 2 0 0 2 2 2 0 Probable molybdopterin binding domain FlxA PF14282.6 EGD96929.1 - 0.068 13.2 6.2 0.13 12.3 1.8 3.4 3 0 0 3 3 3 0 FlxA-like protein BBP1_C PF15272.6 EGD96929.1 - 0.1 12.4 5.4 3.8 7.3 0.9 3.0 2 0 0 2 2 2 0 Spindle pole body component BBP1, C-terminal MPS2 PF17060.5 EGD96929.1 - 0.11 11.7 1.3 0.14 11.4 0.0 1.8 2 0 0 2 2 2 0 Monopolar spindle protein 2 Lebercilin PF15619.6 EGD96929.1 - 0.23 11.1 15.3 0.14 11.8 1.6 2.7 2 1 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease DUF641 PF04859.12 EGD96929.1 - 1 9.7 7.7 1.4 9.3 0.4 3.4 2 1 1 3 3 3 0 Plant protein of unknown function (DUF641) Tho2 PF11262.8 EGD96929.1 - 1.1 8.4 4.3 1.9 7.6 4.3 1.3 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 Ank_2 PF12796.7 EGD96930.1 - 6e-88 289.5 12.5 1.5e-17 63.9 0.2 6.5 1 1 8 9 9 9 9 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EGD96930.1 - 8e-50 166.6 1.8 3e-08 34.0 0.0 9.6 2 1 8 10 10 10 10 Ankyrin repeats (many copies) Ank_5 PF13857.6 EGD96930.1 - 2.4e-42 142.4 8.8 5.5e-09 36.1 0.0 7.7 3 1 6 9 9 9 8 Ankyrin repeats (many copies) Ank_3 PF13606.6 EGD96930.1 - 6.2e-42 136.8 2.6 0.001 19.4 0.0 11.9 12 0 0 12 12 12 8 Ankyrin repeat Ank PF00023.30 EGD96930.1 - 3.4e-41 137.9 11.5 0.00028 21.2 0.0 12.0 12 0 0 12 12 12 8 Ankyrin repeat F-box-like PF12937.7 EGD96930.1 - 0.011 15.6 0.0 0.02 14.8 0.0 1.4 1 0 0 1 1 1 0 F-box-like PEGA PF08308.11 EGD96930.1 - 0.021 14.7 0.0 48 3.9 0.0 3.9 4 0 0 4 4 4 0 PEGA domain VWA_3_C PF18571.1 EGD96930.1 - 0.025 14.4 2.7 44 4.0 0.0 4.9 5 0 0 5 5 5 0 von Willebrand factor type A C-terminal domain DUF4988 PF16378.5 EGD96930.1 - 0.071 12.8 0.0 11 5.7 0.0 2.7 3 0 0 3 3 3 0 Domain of unknown function NOGCT PF08155.11 EGD96932.1 - 0.082 12.9 0.1 0.21 11.6 0.1 1.6 1 0 0 1 1 1 0 NOGCT (NUC087) domain DAGAT PF03982.13 EGD96933.1 - 4e-91 305.0 0.0 4.9e-91 304.7 0.0 1.1 1 0 0 1 1 1 1 Diacylglycerol acyltransferase Rer1 PF03248.13 EGD96933.1 - 0.055 13.2 3.2 0.12 12.1 3.2 1.5 1 0 0 1 1 1 0 Rer1 family G-patch PF01585.23 EGD96935.1 - 0.00043 20.1 0.1 0.0073 16.2 0.1 2.6 1 1 0 1 1 1 1 G-patch domain FAM60A PF15396.6 EGD96935.1 - 0.11 12.5 15.9 0.2 11.6 15.9 1.5 1 0 0 1 1 1 0 Protein Family FAM60A Asp-B-Hydro_N PF05279.11 EGD96935.1 - 0.94 9.5 22.7 1.3 9.0 22.7 1.2 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region CRT10 PF08728.10 EGD96935.1 - 1.1 7.4 6.8 1.3 7.1 6.8 1.1 1 0 0 1 1 1 0 CRT10 Dsh_C PF12316.8 EGD96935.1 - 1.8 8.9 11.5 3.6 7.9 11.5 1.4 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal DUF966 PF06136.13 EGD96935.1 - 2.6 7.7 19.0 3.4 7.3 19.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF966) DUF5521 PF17659.1 EGD96935.1 - 3.6 5.3 9.3 4.8 4.9 9.3 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5521) LAP1C PF05609.12 EGD96935.1 - 4.9 6.1 19.7 6.2 5.8 19.7 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Presenilin PF01080.17 EGD96935.1 - 5.1 5.8 19.4 7.2 5.3 19.4 1.2 1 0 0 1 1 1 0 Presenilin Coilin_N PF15862.5 EGD96935.1 - 6.4 6.6 30.5 0.33 10.8 7.5 2.3 2 0 0 2 2 2 0 Coilin N-terminus Med19 PF10278.9 EGD96935.1 - 6.6 6.6 38.0 8.8 6.2 19.4 2.4 2 0 0 2 2 2 0 Mediator of RNA pol II transcription subunit 19 SOBP PF15279.6 EGD96935.1 - 9.5 6.7 11.9 14 6.2 11.9 1.3 1 0 0 1 1 1 0 Sine oculis-binding protein GREB1 PF15782.5 EGD96935.1 - 9.8 3.1 14.6 12 2.9 14.6 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer FCH PF00611.23 EGD96936.1 - 0.00017 21.8 2.2 0.00039 20.6 2.2 1.7 1 0 0 1 1 1 1 Fes/CIP4, and EFC/F-BAR homology domain Muted PF14942.6 EGD96936.1 - 0.14 12.5 8.2 0.21 11.9 8.2 1.3 1 0 0 1 1 1 0 Organelle biogenesis, Muted-like protein NAM-associated PF14303.6 EGD96936.1 - 0.46 11.2 12.2 0.65 10.7 12.2 1.3 1 1 0 1 1 1 0 No apical meristem-associated C-terminal domain DUF5446 PF17522.2 EGD96936.1 - 6.6 7.0 8.2 4.7 7.4 0.6 2.4 1 1 1 2 2 2 0 Family of unknown function (DUF5446) Syja_N PF02383.18 EGD96937.1 - 1.7e-73 247.7 0.0 2.5e-73 247.2 0.0 1.2 1 0 0 1 1 1 1 SacI homology domain Exo_endo_phos PF03372.23 EGD96937.1 - 6.1e-06 25.9 0.0 1.1e-05 25.1 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Pkinase PF00069.25 EGD96938.1 - 2e-62 211.0 0.0 2.4e-62 210.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD96938.1 - 1.5e-34 119.5 0.0 2.1e-34 119.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EGD96938.1 - 0.096 12.0 0.0 0.2 10.9 0.0 1.5 1 0 0 1 1 1 0 Kinase-like APH PF01636.23 EGD96938.1 - 0.17 11.8 0.0 0.32 10.9 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EGD96938.1 - 0.19 10.5 0.0 0.28 9.9 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase IGR PF09597.10 EGD96939.1 - 2.9e-22 78.5 2.3 5.4e-22 77.6 2.3 1.5 1 0 0 1 1 1 1 IGR protein motif p450 PF00067.22 EGD96940.1 - 7.9e-69 232.6 0.0 1e-68 232.2 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 K-box PF01486.17 EGD96940.1 - 0.075 13.2 0.1 0.19 11.9 0.1 1.6 1 0 0 1 1 1 0 K-box region DUF3045 PF11243.8 EGD96940.1 - 0.14 12.3 0.0 0.32 11.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3045) Pkinase PF00069.25 EGD96941.1 - 8.4e-70 235.1 0.0 1.1e-69 234.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD96941.1 - 5e-36 124.3 0.0 6.7e-36 123.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase FHA PF00498.26 EGD96941.1 - 4.5e-16 59.0 0.2 1.1e-15 57.7 0.2 1.7 1 0 0 1 1 1 1 FHA domain Kinase-like PF14531.6 EGD96941.1 - 1e-06 28.3 0.0 1.1e-05 24.9 0.0 2.1 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 EGD96941.1 - 8.2e-05 21.5 0.0 0.00013 20.9 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Yop-YscD_cpl PF16697.5 EGD96941.1 - 0.0014 18.9 0.0 0.0035 17.6 0.0 1.6 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain Kdo PF06293.14 EGD96941.1 - 0.0043 16.4 0.1 0.0071 15.7 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 EGD96941.1 - 0.033 13.1 0.3 0.051 12.5 0.3 1.2 1 0 0 1 1 1 0 Haspin like kinase domain Pox_ser-thr_kin PF05445.11 EGD96941.1 - 0.082 11.9 0.0 0.12 11.3 0.0 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase PI3_PI4_kinase PF00454.27 EGD96942.1 - 1.7e-37 129.6 0.0 4.9e-35 121.5 0.0 2.8 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 EGD96942.1 - 1.7e-24 86.3 0.0 3.7e-24 85.1 0.0 1.5 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) DUF4135 PF13575.6 EGD96942.1 - 0.076 12.3 0.0 0.15 11.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4135) Pkinase PF00069.25 EGD96943.1 - 2e-23 83.1 0.0 2.5e-23 82.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD96943.1 - 3.5e-05 23.2 0.0 6.1e-05 22.4 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EGD96943.1 - 0.0045 16.4 0.0 0.0068 15.8 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pox_ser-thr_kin PF05445.11 EGD96943.1 - 0.026 13.5 0.3 0.036 13.1 0.3 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Chorion_2 PF03964.15 EGD96944.1 - 0.024 15.5 5.4 0.024 15.5 5.4 2.5 2 1 0 2 2 2 0 Chorion family 2 ArfGap PF01412.18 EGD96945.1 - 2.2e-32 111.6 0.0 2.2e-32 111.6 0.0 2.2 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf BAR_3 PF16746.5 EGD96945.1 - 1.2e-17 64.5 8.5 1.9e-17 63.8 8.5 1.3 1 0 0 1 1 1 1 BAR domain of APPL family PH PF00169.29 EGD96945.1 - 1.4e-11 44.8 0.5 4.1e-11 43.3 0.2 2.0 2 0 0 2 2 2 1 PH domain LSM PF01423.22 EGD96947.1 - 1.5e-21 75.8 0.1 1.7e-21 75.6 0.1 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EGD96947.1 - 0.13 12.4 0.1 0.13 12.4 0.1 1.1 1 0 0 1 1 1 0 Ataxin 2 SM domain Ank_2 PF12796.7 EGD96948.1 - 2.3e-51 172.3 0.2 2.9e-12 47.0 0.0 6.1 2 1 4 7 7 7 7 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EGD96948.1 - 8.9e-46 153.7 6.5 4.6e-08 33.4 0.5 10.5 3 1 9 12 12 12 11 Ankyrin repeats (many copies) Ank_3 PF13606.6 EGD96948.1 - 5.2e-37 121.6 3.3 0.00018 21.7 0.1 12.5 13 0 0 13 13 13 8 Ankyrin repeat Ank PF00023.30 EGD96948.1 - 7.1e-37 124.3 10.7 8.1e-08 32.4 0.0 10.8 11 0 0 11 11 11 7 Ankyrin repeat Ank_5 PF13857.6 EGD96948.1 - 8e-28 96.2 9.4 9.1e-06 25.9 0.0 8.5 5 2 5 10 10 10 6 Ankyrin repeats (many copies) Asp_protease_2 PF13650.6 EGD96948.1 - 0.057 14.1 0.2 13 6.5 0.0 4.1 3 1 1 4 4 4 0 Aspartyl protease RVP PF00077.20 EGD96948.1 - 0.099 13.0 0.0 11 6.4 0.0 3.3 3 1 0 3 3 3 0 Retroviral aspartyl protease Fungal_trans_2 PF11951.8 EGD96950.1 - 5e-28 98.0 0.3 6.9e-28 97.5 0.3 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EGD96950.1 - 1.8e-08 34.4 10.0 3.3e-08 33.5 10.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PBP1_TM PF14812.6 EGD96951.1 - 0.002 18.4 2.5 0.0027 18.1 2.5 1.1 1 0 0 1 1 1 1 Transmembrane domain of transglycosylase PBP1 at N-terminal CENP-B_dimeris PF09026.10 EGD96951.1 - 0.027 14.9 4.8 0.03 14.7 4.8 1.2 1 0 0 1 1 1 0 Centromere protein B dimerisation domain NOA36 PF06524.12 EGD96951.1 - 0.23 10.8 5.9 0.26 10.6 5.9 1.0 1 0 0 1 1 1 0 NOA36 protein DUF2457 PF10446.9 EGD96951.1 - 0.42 9.7 7.1 0.42 9.7 7.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) FAM176 PF14851.6 EGD96951.1 - 2.1 8.0 4.4 2.8 7.6 4.4 1.4 1 1 0 1 1 1 0 FAM176 family AA_permease PF00324.21 EGD96952.1 - 1.1e-141 472.7 36.2 1.4e-141 472.4 36.2 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EGD96952.1 - 4e-34 118.2 37.0 5.5e-34 117.7 37.0 1.1 1 0 0 1 1 1 1 Amino acid permease APH PF01636.23 EGD96953.1 - 3.6e-11 43.4 0.0 1.6e-07 31.5 0.0 2.4 2 0 0 2 2 2 2 Phosphotransferase enzyme family DUF1679 PF07914.11 EGD96953.1 - 3.6e-05 22.8 0.1 0.29 9.9 0.0 3.0 3 0 0 3 3 3 2 Protein of unknown function (DUF1679) Fructosamin_kin PF03881.14 EGD96953.1 - 0.0081 15.4 0.0 1.4 8.1 0.0 2.2 2 0 0 2 2 2 2 Fructosamine kinase RhoGAP PF00620.27 EGD96954.1 - 7.8e-14 51.8 0.2 3.3e-13 49.7 0.0 2.1 2 0 0 2 2 2 1 RhoGAP domain FCH PF00611.23 EGD96954.1 - 8.3e-11 42.0 0.2 8.3e-10 38.8 0.0 2.7 3 0 0 3 3 3 1 Fes/CIP4, and EFC/F-BAR homology domain DEP PF00610.21 EGD96954.1 - 1.6e-09 37.6 0.0 3.4e-09 36.6 0.0 1.6 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) YojJ PF10372.9 EGD96954.1 - 0.035 14.2 1.3 0.24 11.5 0.5 2.7 2 0 0 2 2 2 0 Bacterial membrane-spanning protein N-terminus RTA1 PF04479.13 EGD96955.1 - 5.9e-33 114.2 2.4 8.2e-33 113.8 2.4 1.2 1 0 0 1 1 1 1 RTA1 like protein Asp-Al_Ex PF06826.12 EGD96955.1 - 0.054 13.3 0.5 0.1 12.4 0.5 1.4 1 0 0 1 1 1 0 Predicted Permease Membrane Region AAA PF00004.29 EGD96956.1 - 2.5e-14 53.8 0.0 6.2e-14 52.6 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EGD96956.1 - 8.5e-14 52.0 0.1 5.3e-13 49.4 0.0 2.3 2 1 1 3 3 3 1 AAA domain AAA_16 PF13191.6 EGD96956.1 - 1.3e-12 48.5 0.4 2.6e-11 44.2 0.1 2.9 2 1 0 2 2 2 1 AAA ATPase domain Cdc6_C PF09079.11 EGD96956.1 - 3.8e-08 33.2 0.0 9.9e-08 31.9 0.0 1.7 1 0 0 1 1 1 1 CDC6, C terminal winged helix domain TniB PF05621.11 EGD96956.1 - 2.1e-06 27.3 0.0 4.1e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 Bacterial TniB protein NTPase_1 PF03266.15 EGD96956.1 - 0.00035 20.5 0.0 0.00061 19.7 0.0 1.4 1 0 0 1 1 1 1 NTPase AAA_7 PF12775.7 EGD96956.1 - 0.00044 19.8 0.0 0.001 18.6 0.0 1.6 1 0 0 1 1 1 1 P-loop containing dynein motor region TIP49 PF06068.13 EGD96956.1 - 0.00063 19.1 0.0 0.001 18.4 0.0 1.2 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_19 PF13245.6 EGD96956.1 - 0.00067 20.0 0.0 0.0018 18.6 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_lid_10 PF17872.1 EGD96956.1 - 0.0013 18.8 0.0 0.0033 17.5 0.0 1.6 1 0 0 1 1 1 1 AAA lid domain AAA_30 PF13604.6 EGD96956.1 - 0.0017 18.1 0.0 0.0038 17.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain NB-ARC PF00931.22 EGD96956.1 - 0.0019 17.4 0.0 0.0037 16.5 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain AAA_5 PF07728.14 EGD96956.1 - 0.002 18.1 0.0 0.0048 16.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) T2SSE PF00437.20 EGD96956.1 - 0.0026 16.9 0.0 0.0055 15.8 0.0 1.5 1 0 0 1 1 1 1 Type II/IV secretion system protein PIF1 PF05970.14 EGD96956.1 - 0.0037 16.5 0.0 0.0062 15.8 0.0 1.2 1 0 0 1 1 1 1 PIF1-like helicase ABC_tran PF00005.27 EGD96956.1 - 0.0049 17.4 0.0 0.015 15.8 0.0 1.8 1 0 0 1 1 1 1 ABC transporter ATPase_2 PF01637.18 EGD96956.1 - 0.0058 16.6 0.0 0.0093 15.9 0.0 1.4 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea KAP_NTPase PF07693.14 EGD96956.1 - 0.0072 15.6 0.0 0.012 14.9 0.0 1.3 1 0 0 1 1 1 1 KAP family P-loop domain RNA12 PF10443.9 EGD96956.1 - 0.0093 14.7 0.0 0.014 14.1 0.0 1.3 1 0 0 1 1 1 1 RNA12 protein RNA_helicase PF00910.22 EGD96956.1 - 0.01 16.2 0.1 0.029 14.8 0.0 1.9 2 0 0 2 2 1 1 RNA helicase AAA_18 PF13238.6 EGD96956.1 - 0.013 16.1 0.0 0.022 15.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain RuvB_N PF05496.12 EGD96956.1 - 0.017 14.9 0.0 0.047 13.4 0.0 1.7 1 1 1 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain AAA_24 PF13479.6 EGD96956.1 - 0.018 14.8 0.0 0.037 13.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.6 EGD96956.1 - 0.042 13.6 0.0 0.11 12.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain Rad17 PF03215.15 EGD96956.1 - 0.057 13.3 0.0 0.12 12.3 0.0 1.5 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_28 PF13521.6 EGD96956.1 - 0.059 13.6 0.0 0.2 11.9 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_14 PF13173.6 EGD96956.1 - 0.078 13.0 0.0 0.18 11.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 EGD96956.1 - 0.13 12.1 0.0 0.31 10.8 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain MeaB PF03308.16 EGD96956.1 - 0.15 11.0 0.0 0.27 10.2 0.0 1.3 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB DUF2075 PF09848.9 EGD96956.1 - 0.17 11.1 0.0 0.26 10.5 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) TsaE PF02367.17 EGD96956.1 - 0.19 11.8 0.0 0.41 10.7 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Herpes_US12 PF05363.12 EGD96956.1 - 1.2 9.9 4.9 24 5.8 0.1 3.5 3 0 0 3 3 3 0 Herpesvirus US12 family Thioredoxin_7 PF13899.6 EGD96957.1 - 3.6e-15 55.9 0.0 7.8e-15 54.8 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin-like UBA_4 PF14555.6 EGD96957.1 - 1.2e-13 50.7 0.1 2.1e-13 49.8 0.1 1.5 1 0 0 1 1 1 1 UBA-like domain UBX PF00789.20 EGD96957.1 - 3.9e-07 30.2 0.0 1.3e-06 28.6 0.0 1.9 2 0 0 2 2 2 1 UBX domain Thioredoxin_2 PF13098.6 EGD96957.1 - 0.068 13.6 0.0 0.14 12.6 0.0 1.5 1 0 0 1 1 1 0 Thioredoxin-like domain DUF1299 PF06975.11 EGD96957.1 - 0.15 12.1 0.3 1.2 9.3 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1299) Pkinase PF00069.25 EGD96959.1 - 5.9e-69 232.4 0.0 8.2e-69 231.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD96959.1 - 1.6e-50 171.8 0.0 2.4e-50 171.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EGD96959.1 - 3.7e-06 26.0 0.9 4.8e-05 22.3 0.0 2.2 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 EGD96959.1 - 0.027 13.8 0.0 0.45 9.8 0.0 2.2 2 0 0 2 2 2 0 Kinase-like Haspin_kinase PF12330.8 EGD96959.1 - 0.19 10.7 0.4 27 3.5 0.0 2.8 2 1 1 3 3 3 0 Haspin like kinase domain COesterase PF00135.28 EGD96960.1 - 2.2e-65 221.5 0.0 4.4e-65 220.5 0.0 1.5 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EGD96960.1 - 3.7e-09 36.8 0.0 7.2e-09 35.8 0.0 1.4 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EGD96960.1 - 0.051 13.0 0.0 0.12 11.8 0.0 1.6 1 1 1 2 2 2 0 Prolyl oligopeptidase family Fungal_trans PF04082.18 EGD96961.1 - 1.1e-23 83.6 0.0 1.6e-23 83.1 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EGD96961.1 - 5.5e-08 32.8 12.1 9.9e-08 32.0 12.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Trimer_CC PF08954.11 EGD96961.1 - 0.1 12.2 0.4 0.35 10.5 0.4 1.9 1 0 0 1 1 1 0 Trimerisation motif MR_MLE_C PF13378.6 EGD96963.1 - 1e-41 143.0 0.0 1.5e-41 142.4 0.0 1.2 1 0 0 1 1 1 1 Enolase C-terminal domain-like MR_MLE_N PF02746.16 EGD96963.1 - 1.3e-09 38.3 0.0 2.1e-09 37.6 0.0 1.3 1 0 0 1 1 1 1 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain Beta-lactamase PF00144.24 EGD96964.1 - 2.2e-23 83.0 0.0 3.5e-23 82.4 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase adh_short_C2 PF13561.6 EGD96965.1 - 2.8e-52 177.6 0.0 7.4e-52 176.2 0.0 1.5 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EGD96965.1 - 7.2e-39 133.3 0.1 3.1e-38 131.2 0.1 1.8 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EGD96965.1 - 2e-05 24.6 0.2 3.4e-05 23.8 0.2 1.3 1 0 0 1 1 1 1 KR domain DUF3431 PF11913.8 EGD96966.1 - 2.6e-84 282.3 0.1 3.3e-84 282.0 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3431) FlxA PF14282.6 EGD96966.1 - 0.015 15.3 1.5 0.03 14.3 1.5 1.4 1 0 0 1 1 1 0 FlxA-like protein Mucin2_WxxW PF13330.6 EGD96967.1 - 0.041 14.7 0.0 0.095 13.5 0.0 1.6 1 0 0 1 1 1 0 Mucin-2 protein WxxW repeating region ox_reductase_C PF08635.10 EGD96970.1 - 0.098 12.3 0.0 0.15 11.7 0.0 1.3 1 0 0 1 1 1 0 Putative oxidoreductase C terminal domain Amidohydro_2 PF04909.14 EGD96971.1 - 1.4e-05 25.0 0.0 8.1e-05 22.5 0.0 1.9 1 1 1 2 2 2 1 Amidohydrolase ADH_N PF08240.12 EGD96972.1 - 2.7e-24 85.1 0.2 5.8e-24 84.1 0.2 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EGD96972.1 - 2.9e-24 85.5 0.2 4.4e-24 84.9 0.2 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EGD96972.1 - 0.0014 19.7 0.0 0.0023 19.0 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 EGD96972.1 - 0.03 13.8 0.2 0.076 12.5 0.2 1.6 1 1 0 1 1 1 0 Glucose dehydrogenase C-terminus v110 PF01639.17 EGD96972.1 - 0.064 13.1 0.6 0.11 12.3 0.6 1.3 1 0 0 1 1 1 0 Viral family 110 Methyltransf_32 PF13679.6 EGD96972.1 - 0.088 12.8 0.0 0.15 12.0 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Peripla_BP_6 PF13458.6 EGD96972.1 - 0.17 11.5 0.0 0.25 11.0 0.0 1.2 1 0 0 1 1 1 0 Periplasmic binding protein SWIM PF04434.17 EGD96973.1 - 1.6e-05 24.4 0.2 2.9e-05 23.6 0.2 1.4 1 0 0 1 1 1 1 SWIM zinc finger CobT PF06213.12 EGD96973.1 - 0.26 10.7 8.0 0.8 9.0 5.1 2.1 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT CENP-B_dimeris PF09026.10 EGD96973.1 - 4.3 7.8 7.7 7 7.1 6.3 1.9 2 0 0 2 2 2 0 Centromere protein B dimerisation domain SET PF00856.28 EGD96975.1 - 1.7e-07 31.8 1.3 1.7e-05 25.3 0.1 3.4 2 1 1 3 3 3 2 SET domain TPR_16 PF13432.6 EGD96975.1 - 0.029 15.0 0.2 0.1 13.3 0.2 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat SAP PF02037.27 EGD96975.1 - 0.039 13.7 0.0 0.081 12.7 0.0 1.5 1 0 0 1 1 1 0 SAP domain LolB PF03550.14 EGD96975.1 - 0.067 13.2 0.1 0.2 11.7 0.1 1.8 1 1 0 1 1 1 0 Outer membrane lipoprotein LolB TPR_9 PF13371.6 EGD96975.1 - 0.078 13.1 0.0 0.23 11.7 0.0 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat Allexi_40kDa PF05549.11 EGD96976.1 - 0.16 11.5 0.0 0.16 11.5 0.0 2.8 3 0 0 3 3 3 0 Allexivirus 40kDa protein zf-H2C2_2 PF13465.6 EGD96977.1 - 3.2e-09 36.8 16.5 0.00064 20.0 1.2 3.7 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2 PF00096.26 EGD96977.1 - 2.8e-06 27.5 23.5 0.021 15.3 7.0 3.6 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EGD96977.1 - 0.0006 20.4 20.3 0.13 13.1 5.6 3.6 3 0 0 3 3 3 2 C2H2-type zinc finger zf-Di19 PF05605.12 EGD96977.1 - 0.018 15.3 6.1 0.034 14.5 6.1 1.4 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding Rad50_zn_hook PF04423.14 EGD96977.1 - 0.068 13.0 0.4 0.16 11.8 0.4 1.6 1 0 0 1 1 1 0 Rad50 zinc hook motif zf-C2H2_6 PF13912.6 EGD96977.1 - 0.11 12.6 17.3 0.12 12.4 0.1 3.5 3 0 0 3 3 3 0 C2H2-type zinc finger Zn-ribbon_8 PF09723.10 EGD96977.1 - 0.13 12.4 5.8 0.16 12.1 1.0 2.6 1 1 2 3 3 3 0 Zinc ribbon domain DUF3268 PF11672.8 EGD96977.1 - 0.21 11.9 1.1 0.38 11.1 1.1 1.4 1 0 0 1 1 1 0 zinc-finger-containing domain DZR PF12773.7 EGD96977.1 - 0.48 10.5 6.1 4.9 7.3 6.2 2.2 1 1 1 2 2 2 0 Double zinc ribbon zf-C2H2_9 PF16293.5 EGD96977.1 - 0.55 10.1 2.3 2.1 8.3 0.2 2.5 1 1 1 2 2 2 0 C2H2 type zinc-finger (1 copy) zf-BED PF02892.15 EGD96977.1 - 0.75 9.9 8.7 2 8.5 3.7 2.7 1 1 1 2 2 2 0 BED zinc finger zf-C2H2_jaz PF12171.8 EGD96977.1 - 0.77 10.1 7.6 1.5 9.2 2.4 3.2 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-C2HE PF16278.5 EGD96977.1 - 1.3 9.6 13.7 3.2 8.3 0.5 3.1 1 1 2 3 3 3 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_11 PF16622.5 EGD96977.1 - 1.5 8.7 7.5 0.48 10.2 0.2 2.8 2 0 0 2 2 2 0 zinc-finger C2H2-type zf-C2H2_2 PF12756.7 EGD96977.1 - 3.9 7.9 11.2 2.6 8.4 1.4 3.1 1 1 2 3 3 3 0 C2H2 type zinc-finger (2 copies) Zn_ribbon_SprT PF17283.2 EGD96977.1 - 4.1 7.4 12.3 7.9 6.5 4.0 2.6 1 1 2 3 3 3 0 SprT-like zinc ribbon domain DUF3074 PF11274.8 EGD96978.1 - 2.5e-13 50.4 0.1 9e-08 32.3 0.1 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF3074) GUN4_N PF16416.5 EGD96978.1 - 0.18 11.8 0.0 0.35 10.9 0.0 1.4 1 0 0 1 1 1 0 ARM-like repeat domain, GUN4-N terminal Stk19 PF10494.9 EGD96979.1 - 7e-80 268.2 0.0 8.7e-80 267.9 0.0 1.1 1 0 0 1 1 1 1 Serine-threonine protein kinase 19 Glyco_transf_20 PF00982.21 EGD96980.1 - 1.3e-157 525.3 0.1 2.3e-157 524.5 0.1 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.16 EGD96980.1 - 5.3e-35 120.6 0.0 2.5e-34 118.4 0.0 2.0 1 1 0 1 1 1 1 Trehalose-phosphatase Glyco_transf_5 PF08323.11 EGD96980.1 - 0.02 14.6 0.9 0.075 12.7 0.4 2.0 2 0 0 2 2 2 0 Starch synthase catalytic domain Glyco_trans_1_4 PF13692.6 EGD96980.1 - 0.097 13.1 0.0 0.36 11.3 0.0 2.0 2 0 0 2 2 2 0 Glycosyl transferases group 1 4HBT_3 PF13622.6 EGD96982.1 - 1.3e-47 163.1 0.0 1.5e-47 162.9 0.0 1.0 1 0 0 1 1 1 1 Thioesterase-like superfamily 4HBT PF03061.22 EGD96983.1 - 3.2e-05 24.2 0.0 4.6e-05 23.7 0.0 1.2 1 0 0 1 1 1 1 Thioesterase superfamily MaoC_dehydratas PF01575.19 EGD96983.1 - 0.15 11.6 0.0 0.27 10.8 0.0 1.4 1 0 0 1 1 1 0 MaoC like domain PCI PF01399.27 EGD96985.1 - 2.9e-11 43.8 0.0 9.8e-11 42.1 0.0 1.9 2 0 0 2 2 2 1 PCI domain eIF3m_C_helix PF18005.1 EGD96985.1 - 1.9e-10 40.2 3.6 3.9e-10 39.3 3.6 1.6 1 0 0 1 1 1 1 eIF3 subunit M, C-terminal helix DUF2408 PF10303.9 EGD96985.1 - 0.052 14.1 2.2 0.35 11.4 1.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2408) UME PF08064.13 EGD96985.1 - 0.12 12.3 0.2 0.56 10.2 0.0 2.2 2 0 0 2 2 2 0 UME (NUC010) domain DUF883 PF05957.13 EGD96985.1 - 0.33 11.6 9.6 1.7 9.3 4.5 3.3 4 0 0 4 4 4 0 Bacterial protein of unknown function (DUF883) Ribosomal_S14 PF00253.21 EGD96986.1 - 1.7e-14 53.3 4.9 1.8e-14 53.2 4.9 1.0 1 0 0 1 1 1 1 Ribosomal protein S14p/S29e ADK PF00406.22 EGD96987.1 - 7.1e-41 139.8 0.1 2e-40 138.4 0.1 1.6 1 1 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 EGD96987.1 - 5.2e-35 120.8 0.0 8.4e-35 120.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EGD96987.1 - 1e-08 35.8 0.0 1.6e-08 35.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EGD96987.1 - 6e-05 23.2 0.0 0.00058 20.0 0.0 2.1 1 1 0 1 1 1 1 AAA domain Thymidylate_kin PF02223.17 EGD96987.1 - 0.005 16.5 0.1 0.04 13.6 0.1 2.0 1 1 0 1 1 1 1 Thymidylate kinase Ploopntkinase3 PF18751.1 EGD96987.1 - 0.048 13.6 0.0 0.076 12.9 0.0 1.3 1 0 0 1 1 1 0 P-loop Nucleotide Kinase3 MFS_1 PF07690.16 EGD96989.1 - 1.3e-29 103.2 29.6 1.9e-29 102.7 29.6 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily WTF PF03303.13 EGD96989.1 - 2.5 7.8 5.2 20 4.8 1.2 2.3 2 0 0 2 2 2 0 WTF protein MARVEL PF01284.23 EGD96991.1 - 0.024 14.7 0.5 0.024 14.7 0.5 1.9 2 0 0 2 2 2 0 Membrane-associating domain ECF_trnsprt PF12822.7 EGD96991.1 - 0.04 14.0 0.5 0.065 13.3 0.5 1.4 1 0 0 1 1 1 0 ECF transporter, substrate-specific component DUF1461 PF07314.11 EGD96991.1 - 3.6 7.4 6.0 21 5.0 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1461) FeoB_associated PF12669.7 EGD96991.1 - 4.7 7.7 5.2 14 6.1 0.8 2.7 3 0 0 3 3 3 0 FeoB-associated Cys-rich membrane protein Cnd2 PF05786.14 EGD96992.1 - 0 1027.6 7.1 0 1027.4 7.1 1.0 1 0 0 1 1 1 1 Condensin complex subunit 2 CNDH2_N PF06278.11 EGD96992.1 - 0.019 15.1 2.3 0.02 15.1 0.0 2.2 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, N-terminal Na_Ca_ex PF01699.24 EGD96993.1 - 1.8e-49 167.6 42.1 5.8e-27 94.5 16.7 2.6 2 0 0 2 2 2 2 Sodium/calcium exchanger protein SPC12 PF06645.13 EGD96993.1 - 0.21 11.7 2.1 0.92 9.6 0.3 3.0 2 0 0 2 2 2 0 Microsomal signal peptidase 12 kDa subunit (SPC12) EF-hand_4 PF12763.7 EGD96994.1 - 2e-24 85.6 0.0 1.6e-12 47.3 0.0 2.4 2 0 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand WH2 PF02205.20 EGD96994.1 - 1.2e-10 40.8 0.2 3.8e-10 39.3 0.2 1.9 1 0 0 1 1 1 1 WH2 motif DUF1720 PF08226.11 EGD96994.1 - 6.8e-06 26.4 62.1 2.1e-05 24.9 33.2 6.8 4 3 2 6 6 6 2 Domain of unknown function (DUF1720) EF-hand_1 PF00036.32 EGD96994.1 - 0.0002 20.7 0.0 0.15 11.7 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 EGD96994.1 - 0.00068 20.0 2.7 0.14 12.7 0.0 3.3 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_8 PF13833.6 EGD96994.1 - 0.12 12.2 0.0 4.2 7.3 0.0 2.5 2 0 0 2 2 2 0 EF-hand domain pair RNA_pol_L_2 PF13656.6 EGD96995.1 - 3.9e-26 90.6 0.0 6.6e-26 89.9 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.24 EGD96995.1 - 5.6e-10 38.5 0.0 8.9e-10 37.9 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain SIR2_2 PF13289.6 EGD96995.1 - 0.13 12.4 0.0 0.15 12.2 0.0 1.2 1 0 0 1 1 1 0 SIR2-like domain NMO PF03060.15 EGD96996.1 - 5.6e-31 108.1 4.4 1.5e-25 90.3 1.3 2.1 2 0 0 2 2 2 2 Nitronate monooxygenase FMN_dh PF01070.18 EGD96996.1 - 5e-08 32.4 1.9 8.2e-08 31.7 1.9 1.3 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Glu_synthase PF01645.17 EGD96996.1 - 0.00044 19.5 1.4 0.0006 19.1 1.4 1.1 1 0 0 1 1 1 1 Conserved region in glutamate synthase IMPDH PF00478.25 EGD96996.1 - 0.0099 14.9 7.9 0.037 13.0 3.1 2.5 2 1 0 2 2 2 1 IMP dehydrogenase / GMP reductase domain HRCT1 PF15758.5 EGD96997.1 - 0.15 13.0 7.2 6.6 7.8 0.1 2.6 2 0 0 2 2 2 0 Histidine-rich carboxyl terminus protein 1 Gar1 PF04410.14 EGD96997.1 - 0.9 9.3 4.6 1.7 8.4 4.6 1.4 1 0 0 1 1 1 0 Gar1/Naf1 RNA binding region Dicty_REP PF05086.12 EGD96998.1 - 0.19 9.7 3.7 0.22 9.5 3.7 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein CDC45 PF02724.14 EGD96998.1 - 1.1 7.5 15.1 1.3 7.2 15.1 1.0 1 0 0 1 1 1 0 CDC45-like protein Nop53 PF07767.11 EGD96998.1 - 1.7 8.0 20.9 1.9 7.8 20.9 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) RR_TM4-6 PF06459.12 EGD96998.1 - 5 6.9 8.8 6.3 6.5 8.8 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 MCM_bind PF09739.9 EGD96998.1 - 9.5 4.5 9.4 11 4.3 9.4 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor LRR_4 PF12799.7 EGD96999.1 - 8.4e-06 26.0 5.4 0.61 10.6 0.0 6.8 6 3 3 9 9 9 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EGD96999.1 - 0.071 12.9 1.6 21 4.9 0.0 5.0 6 1 0 6 6 6 0 Leucine rich repeat BSP_II PF05432.11 EGD96999.1 - 0.16 11.6 10.8 0.24 11.0 10.8 1.1 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) LRR_6 PF13516.6 EGD96999.1 - 0.24 11.5 11.7 16 5.8 0.0 6.3 8 0 0 8 8 8 0 Leucine Rich repeat Mt_ATP-synt_B PF05405.14 EGD96999.1 - 1 8.9 11.4 1.8 8.2 11.4 1.3 1 0 0 1 1 1 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) CDC45 PF02724.14 EGD96999.1 - 1.6 6.9 10.3 2.4 6.3 10.3 1.2 1 0 0 1 1 1 0 CDC45-like protein BAF1_ABF1 PF04684.13 EGD96999.1 - 2.6 7.0 15.0 3.3 6.6 15.0 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor SNF2_N PF00176.23 EGD97000.1 - 5.2e-52 176.7 0.1 1.9e-50 171.6 0.1 2.3 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EGD97000.1 - 5.2e-16 59.0 0.1 3.7e-15 56.2 0.0 2.5 3 0 0 3 3 3 1 Helicase conserved C-terminal domain zf-C3HC4 PF00097.25 EGD97000.1 - 6.6e-05 22.7 11.5 6.6e-05 22.7 11.5 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) AAA_34 PF13872.6 EGD97000.1 - 0.00041 19.3 0.0 0.0011 17.9 0.0 1.6 1 0 0 1 1 1 1 P-loop containing NTP hydrolase pore-1 zf-RING_2 PF13639.6 EGD97000.1 - 2.3 8.6 26.5 0.024 14.9 11.7 2.6 2 0 0 2 2 2 0 Ring finger domain C2 PF00168.30 EGD97001.1 - 3.7e-10 40.0 0.0 6.6e-10 39.2 0.0 1.4 1 0 0 1 1 1 1 C2 domain Pex2_Pex12 PF04757.14 EGD97002.1 - 1.3e-42 146.0 3.7 1.6e-42 145.6 3.7 1.1 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-C3HC4_2 PF13923.6 EGD97002.1 - 2.6e-11 43.2 10.0 4.2e-11 42.5 10.0 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EGD97002.1 - 6.7e-11 42.3 10.4 1e-10 41.8 10.4 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 EGD97002.1 - 1.4e-10 40.9 7.6 2.2e-10 40.3 7.6 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EGD97002.1 - 2.4e-10 40.1 5.8 3.5e-10 39.6 5.8 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EGD97002.1 - 4.8e-08 32.9 9.3 9.7e-08 31.9 9.3 1.6 1 0 0 1 1 1 1 RING-type zinc-finger Prok-RING_4 PF14447.6 EGD97002.1 - 4.7e-07 29.6 7.2 7.6e-07 28.9 7.2 1.3 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 EGD97002.1 - 5.6e-07 29.4 6.6 8.8e-07 28.8 6.6 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-rbx1 PF12678.7 EGD97002.1 - 6.1e-07 29.6 7.2 1.2e-06 28.7 7.2 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_4 PF15227.6 EGD97002.1 - 4.6e-06 26.7 9.4 7.9e-06 25.9 9.4 1.4 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_10 PF16685.5 EGD97002.1 - 0.0016 18.5 5.4 0.0029 17.7 5.4 1.3 1 0 0 1 1 1 1 zinc RING finger of MSL2 zf-ANAPC11 PF12861.7 EGD97002.1 - 0.0076 16.3 3.0 0.013 15.5 3.0 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_6 PF14835.6 EGD97002.1 - 0.01 15.7 3.5 0.019 14.8 3.5 1.3 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-Nse PF11789.8 EGD97002.1 - 0.023 14.5 4.9 0.042 13.7 4.9 1.4 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-RING_4 PF14570.6 EGD97002.1 - 0.16 11.8 7.6 0.32 10.8 7.6 1.5 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain Rtf2 PF04641.12 EGD97002.1 - 0.23 10.8 0.9 0.47 9.8 0.9 1.6 1 0 0 1 1 1 0 Rtf2 RING-finger zf-RING_11 PF17123.5 EGD97002.1 - 0.34 10.7 4.1 0.9 9.3 4.1 1.8 1 0 0 1 1 1 0 RING-like zinc finger Zn_ribbon_17 PF17120.5 EGD97002.1 - 0.47 10.1 4.7 0.84 9.3 4.7 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type IBR PF01485.21 EGD97002.1 - 0.51 10.6 4.4 1.2 9.4 4.4 1.7 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain EXS PF03124.14 EGD97003.1 - 2.2e-103 346.1 10.8 2.5e-103 345.9 10.8 1.0 1 0 0 1 1 1 1 EXS family DUF3431 PF11913.8 EGD97004.1 - 2.8e-88 295.3 1.4 3.4e-88 295.0 1.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3431) NIR_SIR PF01077.22 EGD97005.1 - 1.4e-53 180.7 0.0 3e-46 156.8 0.0 2.7 3 0 0 3 3 3 2 Nitrite and sulphite reductase 4Fe-4S domain NIR_SIR_ferr PF03460.17 EGD97005.1 - 1.1e-28 98.9 0.0 9.7e-14 51.0 0.0 2.7 2 0 0 2 2 2 2 Nitrite/Sulfite reductase ferredoxin-like half domain Flavodoxin_1 PF00258.25 EGD97005.1 - 3.5e-28 98.6 0.0 7.2e-28 97.6 0.0 1.6 1 0 0 1 1 1 1 Flavodoxin POR_N PF01855.19 EGD97005.1 - 2.2e-05 24.3 0.9 6.4e-05 22.8 0.1 2.0 2 0 0 2 2 2 1 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg Kei1 PF08552.11 EGD97006.1 - 2.7e-60 203.5 0.1 3.7e-60 203.1 0.1 1.2 1 0 0 1 1 1 1 Inositolphosphorylceramide synthase subunit Kei1 Ras PF00071.22 EGD97007.1 - 8e-60 201.1 0.5 1e-59 200.8 0.5 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EGD97007.1 - 1.1e-36 125.7 0.2 1.7e-36 125.1 0.2 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EGD97007.1 - 4.9e-18 65.2 0.4 5.9e-18 64.9 0.4 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EGD97007.1 - 4.7e-06 26.3 0.1 2.9e-05 23.7 0.1 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EGD97007.1 - 1.4e-05 25.1 0.1 2.8e-05 24.2 0.1 1.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 EGD97007.1 - 1.5e-05 24.5 0.1 2.6e-05 23.7 0.1 1.3 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit RsgA_GTPase PF03193.16 EGD97007.1 - 2.3e-05 24.4 0.2 0.025 14.5 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase Gtr1_RagA PF04670.12 EGD97007.1 - 5.8e-05 22.6 0.3 7e-05 22.3 0.3 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_7 PF12775.7 EGD97007.1 - 0.068 12.7 0.0 0.16 11.5 0.0 1.5 2 0 0 2 2 2 0 P-loop containing dynein motor region Dynamin_N PF00350.23 EGD97007.1 - 0.081 13.0 0.4 9 6.3 0.0 2.7 2 1 1 3 3 3 0 Dynamin family TetR_C_16 PF17920.1 EGD97007.1 - 0.21 11.9 0.0 0.36 11.1 0.0 1.3 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain ATP-synt_C PF00137.21 EGD97008.1 - 1.5e-25 89.3 28.7 1.8e-16 60.2 10.8 2.5 2 0 0 2 2 2 2 ATP synthase subunit C SLATT_5 PF18160.1 EGD97008.1 - 0.57 9.5 5.1 0.12 11.7 0.7 1.9 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain family 5 MoCF_biosynth PF00994.24 EGD97009.1 - 8e-49 165.0 0.0 3.6e-23 81.8 0.1 2.4 2 0 0 2 2 2 2 Probable molybdopterin binding domain MoeA_N PF03453.17 EGD97009.1 - 2.4e-38 131.4 2.7 3.9e-38 130.7 2.7 1.4 1 0 0 1 1 1 1 MoeA N-terminal region (domain I and II) MoeA_C PF03454.15 EGD97009.1 - 1.5e-18 66.8 0.1 3.4e-18 65.6 0.1 1.7 1 0 0 1 1 1 1 MoeA C-terminal region (domain IV) DDHD PF02862.17 EGD97010.1 - 2.6e-26 93.2 0.0 7.4e-16 59.0 0.0 2.8 2 1 1 3 3 3 2 DDHD domain CENP-U PF13097.6 EGD97010.1 - 0.13 12.2 0.1 0.35 10.8 0.1 1.6 1 0 0 1 1 1 0 CENP-A nucleosome associated complex (NAC) subunit FAD_binding_3 PF01494.19 EGD97012.1 - 3.4e-70 237.0 0.0 4.2e-70 236.7 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain Phe_hydrox_dim PF07976.12 EGD97012.1 - 2.2e-35 122.2 0.0 3.6e-35 121.5 0.0 1.4 1 0 0 1 1 1 1 Phenol hydroxylase, C-terminal dimerisation domain DAO PF01266.24 EGD97012.1 - 0.00044 19.9 0.0 0.024 14.2 0.0 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EGD97012.1 - 0.016 14.5 0.0 0.065 12.5 0.0 1.9 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EGD97012.1 - 0.04 14.1 0.0 0.099 12.9 0.0 1.7 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 EGD97012.1 - 0.079 13.5 0.0 0.23 12.1 0.0 1.8 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase ApbA PF02558.16 EGD97012.1 - 0.14 11.8 0.0 0.74 9.4 0.0 2.0 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA LSM PF01423.22 EGD97013.1 - 4.3e-18 64.8 0.8 6.2e-18 64.2 0.8 1.2 1 0 0 1 1 1 1 LSM domain SH2_2 PF14633.6 EGD97013.1 - 0.18 11.2 0.0 0.23 10.9 0.0 1.1 1 0 0 1 1 1 0 SH2 domain PAC1 PF16094.5 EGD97014.1 - 0.00023 20.4 0.2 0.00027 20.2 0.2 1.0 1 0 0 1 1 1 1 Proteasome assembly chaperone 4 PI3K_1B_p101 PF10486.9 EGD97014.1 - 0.36 8.6 2.6 0.39 8.4 2.6 1.0 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit SR-25 PF10500.9 EGD97014.1 - 0.36 10.4 5.7 0.44 10.1 5.7 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Ras PF00071.22 EGD97015.1 - 2e-47 160.8 0.0 2.5e-47 160.5 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EGD97015.1 - 5.6e-20 71.7 0.0 1e-19 70.9 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EGD97015.1 - 0.00016 21.1 0.0 0.00026 20.5 0.0 1.4 1 1 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 EGD97015.1 - 0.022 14.2 0.0 0.036 13.5 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_7 PF12775.7 EGD97015.1 - 0.081 12.4 0.0 0.15 11.5 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region PAP2 PF01569.21 EGD97016.1 - 9.9e-18 64.2 2.4 9.9e-18 64.2 2.4 1.7 2 0 0 2 2 2 1 PAP2 superfamily PAP2_3 PF14378.6 EGD97016.1 - 0.1 12.3 10.6 0.67 9.6 10.6 2.4 1 1 0 1 1 1 0 PAP2 superfamily Peptidase_C48 PF02902.19 EGD97018.1 - 2.7e-26 92.8 0.0 4e-26 92.2 0.0 1.2 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain DUF1664 PF07889.12 EGD97021.1 - 0.0033 17.5 2.8 0.53 10.3 1.2 2.9 1 1 1 2 2 2 2 Protein of unknown function (DUF1664) Spc7 PF08317.11 EGD97021.1 - 0.0093 14.9 1.1 0.014 14.3 1.1 1.2 1 0 0 1 1 1 1 Spc7 kinetochore protein ADIP PF11559.8 EGD97021.1 - 0.01 16.0 2.4 0.13 12.4 2.1 2.3 1 1 0 1 1 1 1 Afadin- and alpha -actinin-Binding CCDC144C PF14915.6 EGD97021.1 - 0.01 15.0 0.2 0.022 13.9 0.1 1.4 1 1 0 1 1 1 0 CCDC144C protein coiled-coil region WEMBL PF05701.11 EGD97021.1 - 0.016 13.9 0.3 0.026 13.2 0.3 1.3 1 0 0 1 1 1 0 Weak chloroplast movement under blue light Fez1 PF06818.15 EGD97021.1 - 0.035 14.6 1.7 0.16 12.4 0.1 2.2 1 1 0 1 1 1 0 Fez1 TPR_MLP1_2 PF07926.12 EGD97021.1 - 0.046 13.8 0.1 5.8 7.0 0.1 2.5 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein COG5 PF10392.9 EGD97021.1 - 0.062 13.5 1.2 0.4 10.9 1.2 2.4 1 1 0 1 1 1 0 Golgi transport complex subunit 5 Baculo_PEP_C PF04513.12 EGD97021.1 - 0.067 13.2 0.2 0.15 12.1 0.1 1.6 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus YlqD PF11068.8 EGD97021.1 - 0.069 13.5 1.0 0.13 12.7 0.2 1.8 2 0 0 2 2 2 0 YlqD protein LPP PF04728.13 EGD97021.1 - 0.071 13.5 6.1 1.6 9.2 0.2 3.8 3 1 1 4 4 3 0 Lipoprotein leucine-zipper CENP-F_leu_zip PF10473.9 EGD97021.1 - 0.096 12.7 0.8 0.44 10.6 0.2 2.4 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF641 PF04859.12 EGD97021.1 - 0.12 12.8 0.9 1.7 9.0 0.2 2.4 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) NPV_P10 PF05531.12 EGD97021.1 - 0.21 12.1 2.1 46 4.6 0.0 3.4 2 2 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Syntaxin_2 PF14523.6 EGD97021.1 - 1.1 9.7 3.9 1.3 9.4 1.8 2.2 1 1 1 2 2 2 0 Syntaxin-like protein TolA_bind_tri PF16331.5 EGD97021.1 - 5.8 7.1 6.1 16 5.7 0.3 3.0 2 1 1 3 3 3 0 TolA binding protein trimerisation Sulfotransfer_3 PF13469.6 EGD97022.1 - 0.0091 16.4 0.0 1.8 8.9 0.0 2.4 2 0 0 2 2 2 2 Sulfotransferase family DUF1542 PF07564.11 EGD97023.1 - 0.11 12.6 0.1 0.24 11.5 0.1 1.5 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1542) Sulfotransfer_3 PF13469.6 EGD97023.1 - 0.15 12.4 0.1 1.4 9.3 0.1 2.1 1 1 0 1 1 1 0 Sulfotransferase family adh_short_C2 PF13561.6 EGD97024.1 - 1.9e-54 184.7 0.4 2.3e-54 184.4 0.4 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EGD97024.1 - 5.6e-47 159.7 0.4 7.1e-47 159.4 0.4 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EGD97024.1 - 2.4e-10 40.6 0.3 6.1e-10 39.3 0.3 1.6 1 1 0 1 1 1 1 KR domain Sacchrp_dh_NADP PF03435.18 EGD97024.1 - 0.0027 18.0 0.0 0.0053 17.0 0.0 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain zf-HIT PF04438.16 EGD97025.1 - 7.4e-10 38.5 10.9 1.3e-09 37.7 10.9 1.4 1 0 0 1 1 1 1 HIT zinc finger DUF5555 PF17710.1 EGD97025.1 - 0.083 12.4 1.7 0.51 9.8 0.6 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5555) zf-MYND PF01753.18 EGD97025.1 - 3 8.0 12.6 6.5 6.9 12.6 1.6 1 0 0 1 1 1 0 MYND finger DENN PF02141.21 EGD97027.1 - 1.1e-37 129.8 0.0 2.1e-37 128.9 0.0 1.5 1 0 0 1 1 1 1 DENN (AEX-3) domain uDENN PF03456.18 EGD97027.1 - 2.8e-06 28.0 0.1 1.3e-05 25.9 0.0 2.2 2 0 0 2 2 2 1 uDENN domain Elongin_A PF06881.11 EGD97027.1 - 0.047 14.2 7.3 0.041 14.4 5.0 2.1 2 0 0 2 2 2 0 RNA polymerase II transcription factor SIII (Elongin) subunit A TMF_TATA_bd PF12325.8 EGD97027.1 - 2.3 8.5 17.5 0.46 10.7 3.8 3.0 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding Cnn_1N PF07989.11 EGD97027.1 - 2.8 8.2 14.2 0.24 11.6 3.8 2.8 2 0 0 2 2 2 0 Centrosomin N-terminal motif 1 Git3 PF11710.8 EGD97028.1 - 8.9e-24 84.4 17.9 2.3e-23 83.1 17.9 1.6 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 GPR_Gpa2_C PF11970.8 EGD97028.1 - 2.4e-10 40.4 0.7 2.4e-10 40.4 0.7 2.5 2 0 0 2 2 2 1 G protein-coupled glucose receptor regulating Gpa2 C-term Dicty_CAR PF05462.11 EGD97028.1 - 0.3 10.2 17.2 0.048 12.8 13.1 1.6 1 1 0 1 1 1 0 Slime mold cyclic AMP receptor MOR2-PAG1_N PF14222.6 EGD97029.1 - 3.8e-210 699.5 0.0 6.1e-210 698.8 0.0 1.4 1 0 0 1 1 1 1 Cell morphogenesis N-terminal MOR2-PAG1_C PF14225.6 EGD97029.1 - 7.8e-70 235.6 1.8 6.8e-53 180.1 0.0 3.1 2 1 1 3 3 3 2 Cell morphogenesis C-terminal MOR2-PAG1_mid PF14228.6 EGD97029.1 - 3.4e-40 137.6 12.0 5.5e-18 64.1 0.1 4.1 2 1 1 3 3 3 3 Cell morphogenesis central region FAD_binding_1 PF00667.20 EGD97030.1 - 4.5e-54 183.4 0.1 1.2e-53 182.0 0.1 1.7 1 1 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 EGD97030.1 - 4.8e-35 120.9 0.7 9.6e-35 119.9 0.7 1.5 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.21 EGD97030.1 - 1.4e-21 77.2 0.0 1.4e-20 74.0 0.0 2.2 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain Flavodoxin_5 PF12724.7 EGD97030.1 - 0.088 13.0 0.1 1.6 9.0 0.0 2.5 2 0 0 2 2 2 0 Flavodoxin domain RRM_1 PF00076.22 EGD97031.1 - 9.6e-22 76.6 0.2 1.6e-10 40.7 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PAPS_reduct PF01507.19 EGD97032.1 - 5.5e-29 101.4 0.0 4.1e-27 95.3 0.0 2.2 1 1 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family DUF3678 PF12435.8 EGD97032.1 - 2.2 7.7 10.0 9.8 5.6 9.5 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3678) RPA_C PF08784.11 EGD97033.1 - 1.4e-13 51.4 0.2 5.8e-13 49.4 0.0 2.1 2 0 0 2 2 2 1 Replication protein A C terminal tRNA_anti-codon PF01336.25 EGD97033.1 - 0.00069 19.5 0.0 0.0035 17.3 0.0 2.1 1 1 0 1 1 1 1 OB-fold nucleic acid binding domain DEAD PF00270.29 EGD97034.1 - 3.8e-47 160.3 0.0 9.1e-47 159.1 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EGD97034.1 - 6.6e-25 87.6 0.1 2.7e-24 85.6 0.1 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DBP10CT PF08147.12 EGD97034.1 - 9.7e-20 70.6 1.7 4e-19 68.6 1.7 2.2 1 0 0 1 1 1 1 DBP10CT (NUC160) domain Coiled-coil_56 PF09813.9 EGD97035.1 - 0.097 12.7 0.0 0.12 12.4 0.0 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 56 Zn_clus PF00172.18 EGD97036.1 - 0.0003 20.8 10.5 0.00054 20.0 10.5 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain AA_permease PF00324.21 EGD97038.1 - 1.1e-103 347.5 32.6 1.2e-103 347.3 32.6 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EGD97038.1 - 3.3e-35 121.7 37.5 3.9e-35 121.5 37.5 1.0 1 0 0 1 1 1 1 Amino acid permease PrgI PF12666.7 EGD97038.1 - 0.021 15.5 1.5 0.021 15.5 1.5 3.3 3 1 1 4 4 4 0 PrgI family protein DEAD PF00270.29 EGD97039.1 - 1.2e-47 161.9 0.1 2.4e-47 161.0 0.1 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EGD97039.1 - 3.5e-24 85.3 0.0 2.9e-23 82.3 0.0 2.6 2 1 1 3 3 3 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 EGD97039.1 - 3.8e-21 75.1 0.0 8.6e-21 73.9 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 EGD97039.1 - 3.3e-08 33.7 0.0 8.3e-08 32.4 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C_2 PF13307.6 EGD97039.1 - 0.0083 16.3 0.1 0.045 13.9 0.0 2.2 2 0 0 2 2 2 1 Helicase C-terminal domain DnaJ PF00226.31 EGD97040.1 - 1.7e-14 53.7 1.3 5.8e-14 52.0 0.4 2.3 2 0 0 2 2 2 1 DnaJ domain Afi1 PF07792.12 EGD97040.1 - 10 6.6 6.5 1.8 9.1 2.8 1.7 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking MatE PF01554.18 EGD97041.1 - 8.5e-55 184.8 31.3 1.5e-34 119.0 11.6 2.3 2 0 0 2 2 2 2 MatE Otopetrin PF03189.13 EGD97041.1 - 0.0054 15.6 1.7 0.062 12.1 0.0 2.5 2 1 0 2 2 2 1 Otopetrin FAM27 PF15832.5 EGD97041.1 - 0.075 13.6 0.2 0.14 12.7 0.2 1.4 1 0 0 1 1 1 0 FAM27 D and E protein family DUF202 PF02656.15 EGD97042.1 - 5.4e-16 58.8 4.8 9.2e-16 58.1 1.1 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF202) SPT16 PF08644.11 EGD97042.1 - 0.16 12.1 0.0 0.21 11.7 0.0 1.2 1 0 0 1 1 1 0 FACT complex subunit (SPT16/CDC68) COX4_pro_2 PF07835.12 EGD97042.1 - 0.3 11.2 1.7 2.9 8.0 0.0 2.3 2 0 0 2 2 2 0 Bacterial aa3 type cytochrome c oxidase subunit IV NUDIX PF00293.28 EGD97043.1 - 7e-27 94.1 0.0 9.1e-27 93.7 0.0 1.1 1 0 0 1 1 1 1 NUDIX domain tRNA-synt_2 PF00152.20 EGD97045.1 - 4.6e-66 223.1 0.0 8.3e-65 218.9 0.0 2.0 1 1 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 EGD97045.1 - 2.6e-07 30.5 0.0 7.8e-07 29.0 0.0 1.9 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain Complex1_LYR PF05347.15 EGD97045.1 - 0.032 14.3 0.1 3.9 7.6 0.0 2.4 2 0 0 2 2 2 0 Complex 1 protein (LYR family) Lactamase_B_6 PF16661.5 EGD97047.1 - 2.4e-65 219.6 0.0 5.3e-65 218.5 0.0 1.6 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain CPSF100_C PF13299.6 EGD97047.1 - 7.1e-46 156.5 0.2 7.1e-46 156.5 0.2 2.5 3 0 0 3 3 3 1 Cleavage and polyadenylation factor 2 C-terminal Beta-Casp PF10996.8 EGD97047.1 - 4.2e-17 62.4 0.0 1.6e-16 60.5 0.0 2.0 1 0 0 1 1 1 1 Beta-Casp domain RMMBL PF07521.12 EGD97047.1 - 7.4e-13 48.2 0.0 1.7e-12 47.1 0.0 1.7 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B PF00753.27 EGD97047.1 - 0.11 12.5 0.0 0.29 11.1 0.0 1.7 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily CDT1_C PF16679.5 EGD97048.1 - 2.3e-19 69.6 0.5 5.1e-19 68.5 0.5 1.6 1 0 0 1 1 1 1 DNA replication factor Cdt1 C-terminal domain Apolipoprotein PF01442.18 EGD97049.1 - 0.00072 19.5 0.3 0.00089 19.2 0.3 1.1 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain ApoC-I PF04691.12 EGD97049.1 - 0.16 11.9 1.3 0.25 11.3 0.9 1.5 1 1 0 1 1 1 0 Apolipoprotein C-I (ApoC-1) DUF883 PF05957.13 EGD97049.1 - 0.52 10.9 4.3 1.7 9.3 4.1 1.9 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF883) Frag1 PF10277.9 EGD97050.1 - 9.6e-41 139.7 6.3 9.6e-41 139.7 6.3 2.4 2 1 0 2 2 2 1 Frag1/DRAM/Sfk1 family Exo_endo_phos PF03372.23 EGD97050.1 - 0.021 14.4 0.0 0.037 13.5 0.0 1.3 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family U3_assoc_6 PF08640.11 EGD97051.1 - 1e-28 99.2 1.4 1e-28 99.2 1.4 2.1 2 0 0 2 2 2 1 U3 small nucleolar RNA-associated protein 6 TPR_14 PF13428.6 EGD97051.1 - 7.5e-05 23.2 4.5 0.022 15.5 0.4 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat Suf PF05843.14 EGD97051.1 - 0.0068 16.4 0.2 0.99 9.3 0.0 2.7 3 0 0 3 3 3 2 Suppressor of forked protein (Suf) NRDE-2 PF08424.10 EGD97051.1 - 0.016 14.3 0.3 0.033 13.3 0.1 1.4 1 1 0 1 1 1 0 NRDE-2, necessary for RNA interference RF-1 PF00472.20 EGD97052.1 - 1.7e-20 73.1 1.2 2.5e-20 72.5 1.2 1.2 1 0 0 1 1 1 1 RF-1 domain MRP-S28 PF10213.9 EGD97052.1 - 0.019 15.4 0.1 0.031 14.7 0.1 1.4 1 1 0 1 1 1 0 Mitochondrial ribosomal subunit protein RRM_1 PF00076.22 EGD97053.1 - 2.7e-09 36.7 0.0 4.6e-09 36.0 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EGD97053.1 - 0.0079 15.8 0.0 0.02 14.5 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) COX6B PF02297.17 EGD97054.1 - 1.8e-23 82.5 4.0 2.3e-23 82.2 4.0 1.1 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb Swi6_N PF18530.1 EGD97054.1 - 0.055 13.6 0.0 0.12 12.6 0.0 1.4 2 0 0 2 2 2 0 Swi6 N-terminal domain CHCH PF06747.13 EGD97054.1 - 0.14 12.3 2.1 2 8.6 0.7 2.5 2 1 0 2 2 2 0 CHCH domain SYS1 PF09801.9 EGD97055.1 - 9.5e-54 181.5 8.0 1.1e-53 181.3 8.0 1.0 1 0 0 1 1 1 1 Integral membrane protein S linking to the trans Golgi network DUF485 PF04341.12 EGD97055.1 - 0.68 9.9 8.1 0.038 13.9 2.6 1.8 2 0 0 2 2 2 0 Protein of unknown function, DUF485 COG5 PF10392.9 EGD97056.1 - 1.3e-37 128.9 1.3 4e-37 127.3 0.0 2.4 3 0 0 3 3 3 1 Golgi transport complex subunit 5 zf-C2H2 PF00096.26 EGD97058.1 - 4.2e-05 23.8 11.7 0.017 15.5 1.6 2.9 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EGD97058.1 - 0.00011 22.4 5.8 0.00032 21.0 3.8 2.7 2 0 0 2 2 2 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 EGD97058.1 - 0.00069 20.2 11.1 0.085 13.7 2.9 3.0 2 0 0 2 2 2 2 C2H2-type zinc finger AMP-binding PF00501.28 EGD97060.1 - 1.9e-139 465.0 0.0 2.7e-71 240.4 0.0 2.2 2 0 0 2 2 2 2 AMP-binding enzyme Condensation PF00668.20 EGD97060.1 - 9.7e-76 255.3 0.0 7.8e-40 136.9 0.0 3.1 2 1 0 2 2 2 2 Condensation domain PP-binding PF00550.25 EGD97060.1 - 3.4e-21 75.4 0.0 3.5e-11 43.3 0.0 2.7 2 0 0 2 2 2 2 Phosphopantetheine attachment site AMP-binding_C PF13193.6 EGD97060.1 - 0.00015 22.7 0.0 1.5 9.9 0.0 3.0 2 0 0 2 2 2 2 AMP-binding enzyme C-terminal domain Transferase PF02458.15 EGD97060.1 - 0.031 12.9 0.1 0.07 11.8 0.0 1.5 2 0 0 2 2 2 0 Transferase family TAL_effector PF03377.13 EGD97060.1 - 0.21 11.9 0.6 0.67 10.3 0.6 1.8 1 0 0 1 1 1 0 TAL effector repeat MFS_1 PF07690.16 EGD97061.1 - 6.9e-38 130.5 51.8 6.9e-38 130.5 51.8 2.1 2 0 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EGD97061.1 - 2.7e-16 59.1 24.7 4.5e-16 58.4 24.7 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 EGD97061.1 - 1.5e-07 30.7 16.0 1.5e-07 30.7 16.0 2.9 3 1 0 3 3 3 2 Sugar (and other) transporter VMR2 PF17055.5 EGD97061.1 - 0.11 12.2 0.0 0.18 11.5 0.0 1.2 1 0 0 1 1 1 0 Viral matrix protein M2 p450 PF00067.22 EGD97062.1 - 2.6e-56 191.3 0.0 3e-56 191.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Methyltransf_33 PF10017.9 EGD97063.1 - 2.2e-59 201.1 0.0 8.1e-29 100.7 0.0 2.0 2 0 0 2 2 2 2 Histidine-specific methyltransferase, SAM-dependent MutS_V PF00488.21 EGD97064.1 - 4.2e-82 274.7 0.1 7.5e-82 273.9 0.1 1.4 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 EGD97064.1 - 4.7e-37 128.1 0.8 1.4e-36 126.5 0.4 2.0 2 0 0 2 2 2 1 MutS domain III MutS_II PF05188.17 EGD97064.1 - 4.6e-23 82.0 0.2 2.7e-22 79.5 0.0 2.3 2 0 0 2 2 2 1 MutS domain II MutS_I PF01624.20 EGD97064.1 - 4.3e-17 62.4 0.0 4.3e-16 59.1 0.0 2.4 2 0 0 2 2 2 1 MutS domain I MutS_IV PF05190.18 EGD97064.1 - 1.6e-15 57.2 0.8 5.4e-15 55.5 0.8 2.0 1 0 0 1 1 1 1 MutS family domain IV Gpi1 PF05024.15 EGD97065.1 - 2.6e-75 252.6 9.6 5e-75 251.7 9.6 1.5 1 0 0 1 1 1 1 N-acetylglucosaminyl transferase component (Gpi1) SOG2 PF10428.9 EGD97066.1 - 5.8 6.0 11.7 8.2 5.5 11.7 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein UPF0203 PF05254.12 EGD97067.1 - 2.1e-26 91.9 3.5 2.5e-26 91.7 3.5 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0203) COX17 PF05051.13 EGD97067.1 - 3.4e-05 24.1 1.0 7.9e-05 22.9 1.0 1.6 1 1 0 1 1 1 1 Cytochrome C oxidase copper chaperone (COX17) Cmc1 PF08583.10 EGD97067.1 - 0.0025 17.8 4.0 0.14 12.2 0.1 2.2 1 1 1 2 2 2 2 Cytochrome c oxidase biogenesis protein Cmc1 like UCR_hinge PF02320.16 EGD97067.1 - 0.17 12.1 4.8 3 8.1 5.1 2.0 1 1 1 2 2 2 0 Ubiquinol-cytochrome C reductase hinge protein DNA_pol_A_exo1 PF01612.20 EGD97068.1 - 1.1e-40 139.2 0.5 1.8e-40 138.5 0.5 1.4 1 0 0 1 1 1 1 3'-5' exonuclease PMC2NT PF08066.12 EGD97068.1 - 1.5e-15 57.6 0.0 4.5e-14 52.9 0.0 2.7 2 0 0 2 2 2 1 PMC2NT (NUC016) domain HRDC PF00570.23 EGD97068.1 - 1.4e-11 44.2 0.6 3.1e-11 43.1 0.1 1.9 2 0 0 2 2 2 1 HRDC domain SelP_N PF04592.14 EGD97068.1 - 0.58 9.5 11.3 1.1 8.6 11.3 1.4 1 0 0 1 1 1 0 Selenoprotein P, N terminal region CPSF73-100_C PF11718.8 EGD97068.1 - 8 5.9 5.9 2.4 7.7 2.7 1.7 2 0 0 2 2 2 0 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term RasGAP PF00616.19 EGD97069.1 - 1.3e-57 194.9 0.1 9.3e-57 192.1 0.0 2.2 2 0 0 2 2 2 1 GTPase-activator protein for Ras-like GTPase RasGAP_C PF03836.15 EGD97069.1 - 2.4e-31 108.7 5.6 2.4e-31 108.7 5.6 2.7 3 1 0 3 3 3 1 RasGAP C-terminus DUF1647 PF07801.11 EGD97069.1 - 0.33 10.7 1.6 0.62 9.8 0.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1647) CRAL_TRIO PF00650.20 EGD97070.1 - 9.8e-39 132.6 0.0 1.4e-38 132.2 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 EGD97070.1 - 4.9e-07 29.8 0.3 4.9e-07 29.8 0.3 2.5 3 0 0 3 3 3 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.6 EGD97070.1 - 0.00053 20.2 0.0 0.00082 19.5 0.0 1.3 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain CPSF100_C PF13299.6 EGD97070.1 - 0.54 10.4 3.8 1.2 9.3 3.3 1.8 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal RNA_pol_Rpc4 PF05132.14 EGD97070.1 - 0.88 10.0 6.0 1.5 9.2 6.0 1.4 1 0 0 1 1 1 0 RNA polymerase III RPC4 Mis14 PF08641.12 EGD97071.1 - 2.2e-22 79.8 5.0 5.1e-22 78.6 5.0 1.6 1 0 0 1 1 1 1 Kinetochore protein Mis14 like RRN3 PF05327.11 EGD97071.1 - 0.57 8.6 3.7 0.79 8.2 3.7 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Acetyltransf_1 PF00583.25 EGD97074.1 - 6.7e-19 68.3 0.0 1.1e-18 67.6 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EGD97074.1 - 6.9e-12 45.4 0.0 1e-11 44.9 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EGD97074.1 - 1.5e-11 44.5 0.0 2.3e-11 44.0 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EGD97074.1 - 2.4e-11 43.5 0.0 3.7e-11 42.8 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_3 PF13302.7 EGD97074.1 - 9e-08 32.9 0.0 1.2e-07 32.4 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 EGD97074.1 - 1.5e-06 27.9 0.0 2.4e-06 27.3 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EGD97074.1 - 1.4e-05 25.1 0.1 3.6e-05 23.9 0.0 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 EGD97074.1 - 0.0003 20.8 0.0 0.00055 20.0 0.0 1.5 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_4 PF13420.7 EGD97074.1 - 0.0033 17.6 0.0 0.0042 17.2 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_13 PF13880.6 EGD97074.1 - 0.029 14.3 0.0 0.05 13.6 0.0 1.3 1 0 0 1 1 1 0 ESCO1/2 acetyl-transferase LCAT PF02450.15 EGD97075.1 - 2.6e-101 339.6 0.0 3.1e-101 339.4 0.0 1.0 1 0 0 1 1 1 1 Lecithin:cholesterol acyltransferase Abhydrolase_6 PF12697.7 EGD97075.1 - 0.00035 21.3 0.1 0.00049 20.8 0.1 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Lipase_2 PF01674.18 EGD97075.1 - 0.04 13.4 0.0 0.068 12.7 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 2) LIDHydrolase PF10230.9 EGD97075.1 - 0.2 11.2 0.0 0.32 10.5 0.0 1.2 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase PAP2_3 PF14378.6 EGD97076.1 - 6.6e-26 91.2 12.4 6.6e-26 91.2 12.4 2.1 2 0 0 2 2 2 1 PAP2 superfamily PAP2 PF01569.21 EGD97076.1 - 4.6e-09 36.1 4.5 4.6e-09 36.1 4.5 1.9 2 0 0 2 2 2 1 PAP2 superfamily Sugar_tr PF00083.24 EGD97078.1 - 4.9e-33 114.7 23.9 7.1e-30 104.3 23.9 2.6 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EGD97078.1 - 2e-32 112.5 25.6 2e-32 112.5 25.6 2.4 1 1 0 2 2 2 1 Major Facilitator Superfamily BT1 PF03092.16 EGD97078.1 - 0.018 13.3 0.3 0.018 13.3 0.3 1.7 2 0 0 2 2 2 0 BT1 family Pkinase PF00069.25 EGD97079.1 - 1e-05 25.0 0.0 2.5e-05 23.8 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain YoeB_toxin PF06769.14 EGD97079.1 - 0.00035 20.5 0.0 0.00063 19.7 0.0 1.5 1 0 0 1 1 1 1 YoeB-like toxin of bacterial type II toxin-antitoxin system DUF1768 PF08719.11 EGD97080.1 - 8.6e-57 191.9 0.0 9.7e-57 191.7 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1768) Pkinase PF00069.25 EGD97081.1 - 8.9e-30 103.9 0.0 6.3e-29 101.1 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD97081.1 - 1.8e-07 30.7 0.0 0.0074 15.6 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase DUF2275 PF10039.9 EGD97082.1 - 0.027 14.6 0.0 0.031 14.4 0.0 1.2 1 0 0 1 1 1 0 Predicted integral membrane protein (DUF2275) TMEMspv1-c74-12 PF11044.8 EGD97082.1 - 0.098 12.7 0.1 0.098 12.7 0.1 1.7 2 0 0 2 2 2 0 Plectrovirus spv1-c74 ORF 12 transmembrane protein EMC3_TMCO1 PF01956.16 EGD97082.1 - 0.1 12.3 0.6 0.12 12.1 0.6 1.3 1 1 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like GRP PF07172.11 EGD97082.1 - 0.21 12.3 0.9 0.39 11.4 0.9 1.6 1 1 0 1 1 1 0 Glycine rich protein family DUF4307 PF14155.6 EGD97082.1 - 0.55 10.1 6.9 2.9 7.8 2.2 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4307) DUF4538 PF15061.6 EGD97082.1 - 0.64 9.8 2.4 20 5.0 0.1 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF4538) S_4TM PF18159.1 EGD97082.1 - 1.9 7.7 4.4 5.7 6.2 4.4 1.7 1 1 0 1 1 1 0 SMODS-associating 4TM effector domain EpuA PF11772.8 EGD97082.1 - 6.5 6.5 8.9 11 5.8 8.9 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase subunit beta DUF1577 PF07614.11 EGD97085.1 - 0.078 12.1 0.1 0.12 11.5 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1577) DUF4058 PF13267.6 EGD97085.1 - 0.16 11.3 0.0 1.7 8.0 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF4058) Gram_pos_anchor PF00746.21 EGD97086.1 - 5.2 7.1 9.1 73 3.4 0.1 5.2 5 0 0 5 5 5 0 LPXTG cell wall anchor motif cNMP_binding PF00027.29 EGD97087.1 - 1.5e-39 134.0 0.0 3.7e-20 71.8 0.0 2.4 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain 2OG-FeII_Oxy_3 PF13640.6 EGD97088.1 - 1.8e-09 38.3 0.0 2.9e-09 37.7 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Forkhead PF00250.18 EGD97089.1 - 5e-18 65.1 0.0 9.6e-18 64.2 0.0 1.5 1 0 0 1 1 1 1 Forkhead domain FHA PF00498.26 EGD97089.1 - 0.00014 22.1 0.0 0.00027 21.2 0.0 1.4 1 0 0 1 1 1 1 FHA domain Snf7 PF03357.21 EGD97090.1 - 2.5e-32 111.8 18.0 2.5e-32 111.8 18.0 2.0 1 1 1 2 2 2 1 Snf7 Pecanex_C PF05041.15 EGD97090.1 - 0.0024 17.5 0.9 0.0033 17.0 0.9 1.1 1 0 0 1 1 1 1 Pecanex protein (C-terminus) CCDC24 PF15669.5 EGD97090.1 - 0.0028 17.6 5.3 0.0044 16.9 5.3 1.3 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 24 family RTBV_P46 PF06216.11 EGD97090.1 - 0.75 8.6 3.2 1.1 8.1 2.7 1.4 1 1 1 2 2 2 0 Rice tungro bacilliform virus P46 protein DUF3138 PF11336.8 EGD97090.1 - 1.2 7.6 6.8 1.1 7.8 5.0 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF3138) Ten1 PF12658.7 EGD97091.1 - 1.5e-39 134.7 0.0 1.8e-39 134.5 0.0 1.0 1 0 0 1 1 1 1 Telomere capping, CST complex subunit Ten1_2 PF15490.6 EGD97091.1 - 0.006 16.3 0.0 0.0091 15.7 0.0 1.4 1 0 0 1 1 1 1 Telomere-capping, CST complex subunit Kelch_5 PF13854.6 EGD97092.1 - 1.1e-18 66.8 8.1 2.6e-08 33.7 0.0 4.6 4 0 0 4 4 4 3 Kelch motif Kelch_4 PF13418.6 EGD97092.1 - 1e-12 47.9 7.3 0.0095 15.9 0.2 5.8 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_6 PF13964.6 EGD97092.1 - 5.1e-11 42.5 6.8 0.04 14.2 0.2 5.2 5 0 0 5 5 5 3 Kelch motif Kelch_3 PF13415.6 EGD97092.1 - 1.7e-10 40.9 6.6 0.003 17.8 0.0 5.8 5 0 0 5 5 5 4 Galactose oxidase, central domain Kelch_1 PF01344.25 EGD97092.1 - 7.7e-07 28.6 5.7 0.053 13.1 0.2 5.2 5 0 0 5 5 5 2 Kelch motif Kelch_2 PF07646.15 EGD97092.1 - 1.3e-06 28.1 1.4 0.16 12.0 0.1 4.5 4 0 0 4 4 4 2 Kelch motif BCAS2 PF05700.11 EGD97093.1 - 1.9e-65 220.4 2.9 2.1e-65 220.3 2.9 1.0 1 0 0 1 1 1 1 Breast carcinoma amplified sequence 2 (BCAS2) Ceramidase_alk PF04734.13 EGD97094.1 - 2.8e-142 474.9 0.0 2.4e-141 471.9 0.0 1.9 2 0 0 2 2 2 1 Neutral/alkaline non-lysosomal ceramidase, N-terminal Ceramidse_alk_C PF17048.5 EGD97094.1 - 3.1e-58 196.4 0.1 4.6e-58 195.8 0.1 1.3 1 0 0 1 1 1 1 Neutral/alkaline non-lysosomal ceramidase, C-terminal EI24 PF07264.11 EGD97096.1 - 3.2e-13 50.3 12.4 7.1e-13 49.2 12.4 1.5 1 1 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) COA2 PF17051.5 EGD97096.1 - 0.22 11.6 0.6 0.44 10.7 0.1 1.7 2 0 0 2 2 2 0 Cytochrome C oxidase assembly factor 2 HNH PF01844.23 EGD97097.1 - 0.0034 17.5 2.3 0.0068 16.6 2.3 1.5 1 0 0 1 1 1 1 HNH endonuclease GTP_EFTU PF00009.27 EGD97099.1 - 7.8e-32 110.4 5.3 3.4e-30 105.0 5.3 2.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain IF-2 PF11987.8 EGD97099.1 - 4.8e-27 94.1 2.9 8.8e-27 93.3 1.0 2.4 2 0 0 2 2 2 1 Translation-initiation factor 2 MMR_HSR1 PF01926.23 EGD97099.1 - 1e-10 41.7 0.1 2.1e-10 40.7 0.1 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase IF2_N PF04760.15 EGD97099.1 - 5.4e-10 38.9 0.0 2.5e-09 36.8 0.0 2.2 2 0 0 2 2 2 1 Translation initiation factor IF-2, N-terminal region GTP_EFTU_D2 PF03144.25 EGD97099.1 - 2.6e-06 27.7 0.3 0.002 18.5 0.0 2.9 2 0 0 2 2 2 1 Elongation factor Tu domain 2 Arf PF00025.21 EGD97099.1 - 9.9e-05 21.9 0.0 0.00018 21.0 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 EGD97099.1 - 0.00015 21.3 0.1 0.00036 20.0 0.1 1.7 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit RsgA_GTPase PF03193.16 EGD97099.1 - 0.0013 18.7 3.5 0.069 13.0 0.2 2.8 1 1 1 2 2 2 1 RsgA GTPase Roc PF08477.13 EGD97099.1 - 0.012 15.8 0.0 0.028 14.6 0.0 1.6 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU_D4 PF14578.6 EGD97099.1 - 0.021 14.7 0.8 0.11 12.5 0.1 2.6 2 1 0 2 2 2 0 Elongation factor Tu domain 4 FeoB_N PF02421.18 EGD97099.1 - 0.027 14.0 0.5 0.08 12.5 0.5 1.8 1 1 0 1 1 1 0 Ferrous iron transport protein B Dynamin_N PF00350.23 EGD97099.1 - 0.031 14.4 0.1 6.3 6.8 0.0 3.0 1 1 1 2 2 2 0 Dynamin family PduV-EutP PF10662.9 EGD97099.1 - 0.11 12.2 0.3 0.33 10.7 0.3 1.8 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation DUF4519 PF15012.6 EGD97099.1 - 6.4 7.0 5.2 2.4 8.4 0.2 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4519) Mito_carr PF00153.27 EGD97100.1 - 5.3e-52 173.7 0.1 3.9e-19 68.4 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Zn_clus PF00172.18 EGD97101.1 - 0.048 13.8 1.7 0.048 13.8 1.7 2.0 2 0 0 2 2 2 0 Fungal Zn(2)-Cys(6) binuclear cluster domain Ribosomal_S2 PF00318.20 EGD97102.1 - 2.2e-65 219.9 0.0 2.3e-64 216.6 0.0 2.0 1 1 0 1 1 1 1 Ribosomal protein S2 Gly_transf_sug PF04488.15 EGD97103.1 - 1.1e-12 48.4 0.2 2.3e-12 47.4 0.2 1.5 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif Acyl_transf_3 PF01757.22 EGD97105.1 - 2.1e-39 135.5 31.2 2.5e-39 135.3 31.2 1.1 1 0 0 1 1 1 1 Acyltransferase family Rick_17kDa_Anti PF05433.15 EGD97107.1 - 4.2e-05 23.3 11.5 4.2e-05 23.3 11.5 2.9 3 1 0 3 3 3 1 Glycine zipper 2TM domain SURF6 PF04935.12 EGD97109.1 - 1.4e-50 171.9 31.7 1.4e-50 171.9 31.7 4.1 2 1 1 3 3 3 1 Surfeit locus protein 6 RRP14 PF15459.6 EGD97109.1 - 4.8e-18 65.5 0.5 4.8e-18 65.5 0.5 8.1 6 2 0 6 6 6 2 60S ribosome biogenesis protein Rrp14 DUF2951 PF11166.8 EGD97109.1 - 0.36 11.1 0.1 0.36 11.1 0.1 5.2 4 3 2 6 6 6 0 Protein of unknown function (DUF2951) Fer4 PF00037.27 EGD97110.1 - 1.5e-13 50.0 16.5 5.7e-08 32.3 3.6 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_7 PF12838.7 EGD97110.1 - 1.4e-12 48.0 10.0 2.2e-12 47.4 10.0 1.3 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_16 PF13484.6 EGD97110.1 - 7.3e-10 39.6 9.8 9.4e-05 23.3 0.9 2.3 1 1 1 2 2 2 2 4Fe-4S double cluster binding domain Fer4_21 PF14697.6 EGD97110.1 - 9.2e-10 38.5 31.2 4.6e-06 26.7 12.1 2.1 1 1 2 3 3 3 3 4Fe-4S dicluster domain Fer4_8 PF13183.6 EGD97110.1 - 1.5e-08 35.0 2.6 0.00033 21.0 0.2 2.2 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_10 PF13237.6 EGD97110.1 - 2.4e-08 34.0 21.3 4.3e-06 26.8 12.2 2.1 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_9 PF13187.6 EGD97110.1 - 3.1e-08 33.7 9.7 6.3e-08 32.7 9.7 1.5 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_6 PF12837.7 EGD97110.1 - 1.4e-06 28.1 17.1 0.00037 20.4 5.4 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_2 PF12797.7 EGD97110.1 - 4.3e-06 26.5 11.8 0.0091 16.0 1.7 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_4 PF12800.7 EGD97110.1 - 7.9e-06 26.0 11.4 0.00028 21.2 1.8 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_17 PF13534.6 EGD97110.1 - 0.00038 20.9 11.8 0.048 14.2 12.9 2.3 1 1 2 3 3 3 3 4Fe-4S dicluster domain c-SKI_SMAD_bind PF08782.10 EGD97110.1 - 0.0087 16.3 5.6 0.49 10.7 0.3 2.2 1 1 1 2 2 2 2 c-SKI Smad4 binding domain Fer4_13 PF13370.6 EGD97110.1 - 0.059 13.9 15.0 0.69 10.5 4.3 2.6 2 1 0 2 2 2 0 4Fe-4S single cluster domain of Ferredoxin I Fer4_18 PF13746.6 EGD97110.1 - 0.074 13.2 9.0 1.1 9.5 1.4 2.2 1 1 1 2 2 2 0 4Fe-4S dicluster domain ETF_QO PF05187.13 EGD97110.1 - 0.1 12.7 5.6 0.46 10.6 0.5 2.2 1 1 1 2 2 2 0 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S Fer4_3 PF12798.7 EGD97110.1 - 0.21 12.6 15.5 0.39 11.7 3.3 2.3 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_22 PF17179.4 EGD97110.1 - 0.89 10.4 12.1 2.1 9.2 1.6 2.2 1 1 1 2 2 2 0 4Fe-4S dicluster domain PP-binding PF00550.25 EGD97111.1 - 1.6e-11 44.4 0.3 2.5e-11 43.7 0.3 1.3 1 0 0 1 1 1 1 Phosphopantetheine attachment site PP-binding_2 PF14573.6 EGD97111.1 - 8.9e-05 22.6 0.1 0.00013 22.2 0.1 1.2 1 0 0 1 1 1 1 Acyl-carrier GPP34 PF05719.11 EGD97112.1 - 7e-68 228.7 0.2 9e-68 228.3 0.2 1.1 1 0 0 1 1 1 1 Golgi phosphoprotein 3 (GPP34) ADH_zinc_N_2 PF13602.6 EGD97113.1 - 3.6e-22 79.8 0.0 7.6e-22 78.8 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 EGD97113.1 - 2e-05 24.6 0.0 3.4e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EGD97113.1 - 0.0052 16.6 0.0 0.011 15.6 0.0 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain DUF2855 PF11017.8 EGD97113.1 - 0.053 13.3 0.0 0.083 12.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2855) DUF2183 PF09949.9 EGD97114.1 - 2.8e-32 111.0 0.0 8.9e-32 109.4 0.0 1.8 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2183) LNS2 PF08235.13 EGD97114.1 - 0.026 14.0 0.0 0.039 13.4 0.0 1.2 1 0 0 1 1 1 0 LNS2 (Lipin/Ned1/Smp2) DUF3885 PF13021.6 EGD97114.1 - 0.13 12.4 0.1 0.37 10.9 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3885) Alfin PF12165.8 EGD97117.1 - 0.14 11.8 0.8 1.1 9.0 0.0 2.6 3 1 0 3 3 3 0 Alfin CBS PF00571.28 EGD97118.1 - 4e-21 75.2 0.7 1.6e-06 28.5 0.0 5.3 5 0 0 5 5 5 5 CBS domain GCS PF03074.16 EGD97119.1 - 2.2e-175 583.4 0.0 2.7e-175 583.1 0.0 1.1 1 0 0 1 1 1 1 Glutamate-cysteine ligase DUF2811 PF10929.8 EGD97119.1 - 0.11 12.8 0.0 0.3 11.4 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2811) NDUF_B7 PF05676.13 EGD97120.1 - 7.2e-30 102.5 6.1 8.8e-30 102.2 6.1 1.1 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) Ank_4 PF13637.6 EGD97121.1 - 1e-12 48.3 0.1 1.1e-06 29.1 0.0 3.2 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 EGD97121.1 - 1.7e-09 38.1 0.0 2.2e-05 25.0 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EGD97121.1 - 7.6e-08 32.0 0.1 1.3e-05 25.2 0.0 3.5 3 0 0 3 3 3 1 Ankyrin repeat Ank_5 PF13857.6 EGD97121.1 - 2.1e-07 31.1 0.2 1.4e-05 25.3 0.0 2.5 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.30 EGD97121.1 - 8.2e-07 29.2 0.4 6.5e-06 26.4 0.0 2.7 3 1 0 3 3 3 1 Ankyrin repeat KilA-N PF04383.13 EGD97121.1 - 0.00011 22.0 0.1 0.0014 18.4 0.1 2.4 1 1 0 1 1 1 1 KilA-N domain DUF3567 PF12091.8 EGD97121.1 - 0.13 12.4 0.5 0.32 11.2 0.5 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3567) DUF4407 PF14362.6 EGD97121.1 - 2.7 7.3 8.3 19 4.5 8.3 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) HALZ PF02183.18 EGD97121.1 - 2.8 8.2 4.7 19 5.6 0.4 2.4 2 0 0 2 2 2 0 Homeobox associated leucine zipper Seryl_tRNA_N PF02403.22 EGD97121.1 - 4 7.7 6.1 13 6.1 5.8 2.0 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain PPL5 PF18168.1 EGD97122.1 - 1.2 8.3 5.8 1.6 7.9 5.8 1.1 1 0 0 1 1 1 0 Prim-pol family 5 Presenilin PF01080.17 EGD97122.1 - 2.1 7.0 6.3 2.4 6.8 6.3 1.1 1 0 0 1 1 1 0 Presenilin CDC45 PF02724.14 EGD97122.1 - 2.8 6.1 13.0 3.3 5.9 13.0 1.1 1 0 0 1 1 1 0 CDC45-like protein FAM176 PF14851.6 EGD97122.1 - 4.8 6.8 12.7 3.2 7.4 3.8 2.1 1 1 1 2 2 2 0 FAM176 family ThrE PF06738.12 EGD97125.1 - 2.6e-66 223.4 11.2 5.2e-62 209.4 0.5 2.4 2 0 0 2 2 2 2 Putative threonine/serine exporter ThrE_2 PF12821.7 EGD97125.1 - 6.5e-09 36.0 11.7 6.5e-09 36.0 11.7 3.0 3 0 0 3 3 3 2 Threonine/Serine exporter, ThrE PS_Dcarbxylase PF02666.15 EGD97129.1 - 1.6e-54 184.5 0.0 2.4e-54 183.9 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase C2 PF00168.30 EGD97129.1 - 4.5e-37 126.5 0.0 1.9e-17 63.4 0.0 2.7 2 0 0 2 2 2 2 C2 domain EF-hand_5 PF13202.6 EGD97129.1 - 0.008 15.6 0.0 0.021 14.3 0.0 1.8 1 0 0 1 1 1 1 EF hand EF-hand_1 PF00036.32 EGD97129.1 - 0.034 13.7 0.0 0.1 12.2 0.0 1.9 1 0 0 1 1 1 0 EF hand GATA PF00320.27 EGD97131.1 - 5.2e-13 48.4 0.9 1.1e-12 47.3 0.9 1.5 1 0 0 1 1 1 1 GATA zinc finger Macro PF01661.21 EGD97135.1 - 6.2e-34 116.6 0.0 1.1e-33 115.8 0.0 1.4 1 0 0 1 1 1 1 Macro domain Ank_2 PF12796.7 EGD97137.1 - 3.8e-13 49.8 0.1 1.2e-07 32.2 0.0 2.7 1 1 2 3 3 3 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EGD97137.1 - 2.8e-06 27.2 2.6 0.0013 19.0 0.0 3.9 4 0 0 4 4 4 1 Ankyrin repeat Ank_4 PF13637.6 EGD97137.1 - 9.3e-06 26.1 0.0 2.6e-05 24.6 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.30 EGD97137.1 - 0.00067 20.0 0.3 0.056 13.9 0.0 3.2 3 0 0 3 3 3 1 Ankyrin repeat Ank_5 PF13857.6 EGD97137.1 - 0.0029 17.9 0.5 0.017 15.5 0.0 2.5 2 1 1 3 3 3 1 Ankyrin repeats (many copies) Peptidase_S24 PF00717.23 EGD97138.1 - 0.00041 20.3 0.0 0.0024 17.8 0.0 2.1 1 1 0 1 1 1 1 Peptidase S24-like AMP-binding PF00501.28 EGD97139.1 - 6.3e-93 311.7 0.0 1.6e-92 310.3 0.0 1.7 2 0 0 2 2 2 1 AMP-binding enzyme ketoacyl-synt PF00109.26 EGD97139.1 - 4.5e-85 285.2 0.1 1.1e-84 283.9 0.0 1.7 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.21 EGD97139.1 - 1.7e-59 201.9 0.9 6.1e-59 200.1 1.1 1.8 2 0 0 2 2 2 1 Acyl transferase domain KR PF08659.10 EGD97139.1 - 9.4e-58 195.1 0.0 1.2e-56 191.4 0.0 2.7 2 0 0 2 2 2 1 KR domain NAD_binding_4 PF07993.12 EGD97139.1 - 4.1e-44 150.7 0.0 7.1e-43 146.6 0.0 2.7 2 1 0 2 2 2 1 Male sterility protein Ketoacyl-synt_C PF02801.22 EGD97139.1 - 1.3e-38 131.6 0.3 3.2e-38 130.4 0.3 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain PP-binding PF00550.25 EGD97139.1 - 5.4e-23 81.1 0.0 2.8e-12 46.8 0.0 3.1 2 0 0 2 2 2 2 Phosphopantetheine attachment site KAsynt_C_assoc PF16197.5 EGD97139.1 - 4.2e-13 49.7 0.0 4.8e-12 46.3 0.0 2.6 3 0 0 3 3 2 1 Ketoacyl-synthetase C-terminal extension Epimerase PF01370.21 EGD97139.1 - 2.5e-12 46.8 0.0 1.1e-07 31.6 0.0 2.4 2 0 0 2 2 2 2 NAD dependent epimerase/dehydratase family AMP-binding_C PF13193.6 EGD97139.1 - 2.7e-08 34.7 0.0 6.9e-08 33.4 0.0 1.8 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain adh_short PF00106.25 EGD97139.1 - 8.7e-08 31.8 0.0 1.5e-05 24.6 0.0 2.6 2 0 0 2 2 2 1 short chain dehydrogenase GDP_Man_Dehyd PF16363.5 EGD97139.1 - 8.7e-07 28.6 0.0 0.0015 18.0 0.0 2.3 2 0 0 2 2 2 2 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 EGD97139.1 - 9.5e-06 24.9 0.0 0.1 11.7 0.0 2.3 2 0 0 2 2 2 2 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.19 EGD97139.1 - 0.00021 20.4 0.0 0.43 9.5 0.1 2.5 2 0 0 2 2 2 2 3-beta hydroxysteroid dehydrogenase/isomerase family Thiolase_N PF00108.23 EGD97139.1 - 0.00024 20.6 0.2 0.00046 19.6 0.2 1.4 1 0 0 1 1 1 1 Thiolase, N-terminal domain NmrA PF05368.13 EGD97139.1 - 0.16 11.5 0.1 0.55 9.8 0.0 2.0 2 0 0 2 2 2 0 NmrA-like family ACP_syn_III PF08545.10 EGD97139.1 - 0.29 11.0 1.1 0.83 9.6 0.3 2.3 2 0 0 2 2 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III PhyH PF05721.13 EGD97140.1 - 1.4e-18 67.9 0.0 2.4e-18 67.2 0.0 1.4 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) Aminotran_1_2 PF00155.21 EGD97141.1 - 3.8e-18 65.8 0.0 4.8e-18 65.5 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_MocR PF12897.7 EGD97141.1 - 0.00021 20.2 0.0 0.0037 16.1 0.0 2.4 1 1 0 2 2 2 1 Alanine-glyoxylate amino-transferase Aminotran_5 PF00266.19 EGD97141.1 - 0.009 15.0 0.0 0.013 14.5 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V NmrA PF05368.13 EGD97142.1 - 1.7e-11 44.1 0.0 3.3e-11 43.2 0.0 1.4 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EGD97142.1 - 2.3e-09 37.4 0.0 4.7e-09 36.4 0.0 1.4 1 1 0 1 1 1 1 NAD(P)H-binding KR PF08659.10 EGD97142.1 - 2.9e-05 24.0 0.3 4.4e-05 23.5 0.3 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EGD97142.1 - 0.00015 21.3 0.0 0.00074 19.0 0.1 2.0 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family CUE PF02845.16 EGD97142.1 - 0.17 11.6 0.3 27 4.6 0.1 2.5 2 0 0 2 2 2 0 CUE domain AA_permease_2 PF13520.6 EGD97143.1 - 1.9e-33 115.9 53.4 2.4e-33 115.6 53.4 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EGD97143.1 - 3.6e-07 29.2 46.4 4.7e-07 28.8 46.4 1.1 1 0 0 1 1 1 1 Amino acid permease Tweety PF04906.13 EGD97143.1 - 0.47 9.1 3.2 0.39 9.3 0.8 2.1 2 0 0 2 2 2 0 Tweety PhyH PF05721.13 EGD97144.1 - 5.9e-22 79.0 0.0 7.5e-22 78.6 0.0 1.1 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) DUF1479 PF07350.12 EGD97144.1 - 0.035 12.9 0.0 0.049 12.4 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1479) Ank_3 PF13606.6 EGD97145.1 - 6e-10 38.5 0.2 0.0033 17.8 0.1 2.9 3 0 0 3 3 3 2 Ankyrin repeat Ank_2 PF12796.7 EGD97145.1 - 1e-09 38.8 0.0 2.8e-09 37.5 0.0 1.8 1 1 1 2 2 2 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EGD97145.1 - 1.2e-09 38.5 0.7 1.6e-07 31.7 0.1 2.6 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 EGD97145.1 - 2.1e-07 31.1 0.1 0.00065 20.0 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.6 EGD97145.1 - 8.4e-07 29.2 0.6 0.026 14.9 0.2 3.2 2 1 0 2 2 2 2 Ankyrin repeats (many copies) MAGE PF01454.19 EGD97146.1 - 5.5e-63 212.5 0.0 9.7e-63 211.7 0.0 1.4 1 0 0 1 1 1 1 MAGE family DUF2997 PF11211.8 EGD97146.1 - 0.1 12.4 0.4 0.22 11.3 0.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2997) Xan_ur_permease PF00860.20 EGD97147.1 - 9.2e-21 74.0 26.1 9.8e-20 70.6 25.9 2.2 1 1 0 1 1 1 1 Permease family Pal1 PF08316.11 EGD97148.1 - 1.3e-46 158.8 0.8 1.3e-46 158.8 0.8 2.4 2 0 0 2 2 2 1 Pal1 cell morphology protein Med31 PF05669.12 EGD97149.1 - 6.7e-32 109.4 0.1 8.6e-32 109.0 0.1 1.1 1 0 0 1 1 1 1 SOH1 Aldolase_II PF00596.21 EGD97151.1 - 5.2e-45 153.7 0.2 6.7e-45 153.3 0.2 1.1 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain CSM2 PF16834.5 EGD97152.1 - 0.096 12.3 0.0 0.15 11.7 0.0 1.3 1 0 0 1 1 1 0 Shu complex component Csm2, DNA-binding PHD PF00628.29 EGD97153.1 - 7.5e-09 35.4 5.1 1.5e-08 34.3 5.1 1.5 1 0 0 1 1 1 1 PHD-finger Choline_kinase PF01633.20 EGD97153.1 - 0.035 13.7 0.0 0.079 12.5 0.0 1.5 2 0 0 2 2 2 0 Choline/ethanolamine kinase Fungal_trans PF04082.18 EGD97154.1 - 8.1e-29 100.5 0.0 1.5e-28 99.6 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EGD97154.1 - 6.9e-11 42.1 13.4 1.3e-10 41.2 13.4 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Gal4_dimer PF03902.13 EGD97154.1 - 0.08 13.1 2.0 0.087 13.0 0.4 1.9 2 0 0 2 2 2 0 Gal4-like dimerisation domain Pkinase PF00069.25 EGD97155.1 - 7.9e-22 77.9 0.0 2.3e-10 40.3 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EGD97155.1 - 0.0021 17.4 0.0 0.96 8.7 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Glyco_trans_2_3 PF13632.6 EGD97156.1 - 0.029 14.3 0.0 0.043 13.7 0.0 1.2 1 0 0 1 1 1 0 Glycosyl transferase family group 2 DUF4770 PF15994.5 EGD97157.1 - 0.17 12.1 1.7 0.24 11.6 1.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) FAM176 PF14851.6 EGD97157.1 - 1.3 8.6 3.8 1.9 8.1 3.8 1.2 1 0 0 1 1 1 0 FAM176 family MCM_bind PF09739.9 EGD97157.1 - 8.7 4.6 6.3 11 4.4 6.3 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor zf-H2C2_2 PF13465.6 EGD97158.1 - 3.6e-05 24.0 3.3 3.6e-05 24.0 3.3 2.5 2 0 0 2 2 2 1 Zinc-finger double domain zf-C2H2 PF00096.26 EGD97158.1 - 4.6e-05 23.6 2.8 4.6e-05 23.6 2.8 3.9 4 0 0 4 4 4 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EGD97158.1 - 0.00015 22.3 1.7 0.00015 22.3 1.7 3.4 4 0 0 4 4 4 1 C2H2-type zinc finger zf-C2H2_6 PF13912.6 EGD97158.1 - 0.0043 17.0 1.3 0.011 15.7 1.3 1.7 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EGD97158.1 - 0.0052 17.0 0.7 0.0052 17.0 0.7 2.1 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2_8 PF15909.5 EGD97158.1 - 0.0087 16.3 3.2 0.026 14.8 3.2 1.9 1 0 0 1 1 1 1 C2H2-type zinc ribbon Forkhead PF00250.18 EGD97159.1 - 8.9e-34 115.6 1.6 1.8e-33 114.7 1.6 1.5 1 0 0 1 1 1 1 Forkhead domain FHA PF00498.26 EGD97159.1 - 2.8e-07 30.8 0.0 2e-06 28.0 0.0 2.2 2 0 0 2 2 2 1 FHA domain Linker_histone PF00538.19 EGD97159.1 - 0.013 15.9 0.2 0.029 14.7 0.2 1.5 1 0 0 1 1 1 0 linker histone H1 and H5 family Ribosomal_L24e PF01246.20 EGD97162.1 - 2.3e-29 101.4 6.3 6.3e-29 100.0 5.9 2.0 2 0 0 2 2 2 1 Ribosomal protein L24e DUF4820 PF16091.5 EGD97162.1 - 0.029 13.8 3.4 0.038 13.4 3.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) DUF4192 PF13830.6 EGD97162.1 - 0.13 12.3 0.9 0.15 12.1 0.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4192) Pam16 PF03656.13 EGD97163.1 - 5.1e-06 26.5 0.2 1.1e-05 25.4 0.2 1.6 1 1 0 1 1 1 1 Pam16 DnaJ PF00226.31 EGD97163.1 - 0.00044 20.3 0.0 0.00067 19.7 0.0 1.3 1 0 0 1 1 1 1 DnaJ domain DUF3918 PF13056.6 EGD97163.1 - 0.0017 17.9 0.9 0.0017 17.9 0.9 2.2 3 0 0 3 3 3 1 Protein of unknown function (DUF3918) Pkinase PF00069.25 EGD97164.1 - 2.1e-59 201.1 0.0 2.9e-59 200.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD97164.1 - 5.3e-27 94.7 0.0 8e-27 94.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EGD97164.1 - 0.0074 15.3 0.0 0.068 12.1 0.0 2.1 2 1 1 3 3 3 1 Haspin like kinase domain Kdo PF06293.14 EGD97164.1 - 0.049 13.0 0.1 0.11 11.9 0.1 1.6 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EGD97164.1 - 0.082 12.8 3.3 0.18 11.7 0.0 2.5 3 0 0 3 3 3 0 Phosphotransferase enzyme family G_glu_transpept PF01019.21 EGD97165.1 - 6e-143 477.3 0.0 6.8e-143 477.1 0.0 1.0 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase p450 PF00067.22 EGD97166.1 - 2.3e-28 99.2 0.0 9.1e-28 97.2 0.0 1.8 2 0 0 2 2 2 1 Cytochrome P450 PsiA PF06952.11 EGD97168.1 - 0.095 11.9 0.1 0.18 11.0 0.1 1.4 1 0 0 1 1 1 0 PsiA protein ICL PF00463.21 EGD97170.1 - 7.3e-297 985.0 1.8 8.3e-297 984.8 1.8 1.0 1 0 0 1 1 1 1 Isocitrate lyase family PEP_mutase PF13714.6 EGD97170.1 - 1.3e-11 44.4 0.0 3.3e-11 43.1 0.0 1.7 2 0 0 2 2 2 1 Phosphoenolpyruvate phosphomutase Trehalase PF01204.18 EGD97171.1 - 1.3e-190 634.6 0.1 1.5e-190 634.4 0.1 1.0 1 0 0 1 1 1 1 Trehalase Trehalase_Ca-bi PF07492.11 EGD97171.1 - 7.2e-17 60.8 0.1 1.2e-16 60.1 0.1 1.4 1 0 0 1 1 1 1 Neutral trehalase Ca2+ binding domain adh_short_C2 PF13561.6 EGD97172.1 - 5.1e-49 166.9 0.0 6e-49 166.7 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EGD97172.1 - 1.6e-46 158.3 0.0 1.9e-46 158.0 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EGD97172.1 - 8.9e-07 29.0 0.0 1.9e-06 27.9 0.0 1.5 1 0 0 1 1 1 1 KR domain HTH_Tnp_IS1 PF12759.7 EGD97172.1 - 0.062 12.9 0.1 59 3.4 0.1 3.2 3 0 0 3 3 3 0 InsA C-terminal domain OTU PF02338.19 EGD97173.1 - 7.1e-20 71.8 0.2 1.8e-19 70.5 0.0 1.8 2 1 0 2 2 2 1 OTU-like cysteine protease Peptidase_C65 PF10275.9 EGD97173.1 - 1e-06 28.4 0.0 0.0012 18.3 0.0 2.5 1 1 0 2 2 2 2 Peptidase C65 Otubain DUF4407 PF14362.6 EGD97173.1 - 0.058 12.7 12.4 0.092 12.1 12.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF4551 PF15087.6 EGD97173.1 - 1.1 8.0 9.3 1.5 7.6 9.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) TPMT PF05724.11 EGD97174.1 - 8.7e-29 100.7 0.1 6.3e-28 97.9 0.1 1.8 1 1 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) Methyltransf_31 PF13847.6 EGD97174.1 - 1e-06 28.6 0.0 4.2e-06 26.6 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EGD97174.1 - 6.8e-05 23.4 0.0 0.00013 22.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EGD97174.1 - 0.00025 21.7 0.0 0.00045 20.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EGD97174.1 - 0.0021 17.9 0.0 0.0027 17.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain N2227 PF07942.12 EGD97174.1 - 0.065 12.4 0.0 0.094 11.9 0.0 1.1 1 0 0 1 1 1 0 N2227-like protein MFS_1 PF07690.16 EGD97175.1 - 7.1e-48 163.3 38.6 3.4e-38 131.5 25.1 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EGD97175.1 - 5e-07 28.9 12.6 5e-07 28.9 12.6 2.5 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_4 PF06779.14 EGD97175.1 - 0.002 17.5 6.5 0.002 17.5 6.5 2.9 3 1 0 3 3 3 1 Uncharacterised MFS-type transporter YbfB OATP PF03137.20 EGD97175.1 - 0.0028 16.0 8.6 0.14 10.4 1.5 2.8 2 1 0 2 2 2 2 Organic Anion Transporter Polypeptide (OATP) family HC2 PF07382.11 EGD97176.1 - 2.6e-11 44.0 1.8 2.6e-11 44.0 1.8 5.7 4 2 0 5 5 5 2 Histone H1-like nucleoprotein HC2 Aldedh PF00171.22 EGD97177.1 - 1.7e-83 280.7 0.0 2e-83 280.4 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Adap_comp_sub PF00928.21 EGD97178.1 - 1e-61 208.7 0.0 1.3e-61 208.3 0.0 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 EGD97178.1 - 0.00031 20.7 0.0 0.00048 20.1 0.0 1.2 1 0 0 1 1 1 1 Clathrin adaptor complex small chain DUF4536 PF15055.6 EGD97179.1 - 0.0026 18.0 1.3 0.0039 17.4 0.3 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4536) DUF1636 PF07845.11 EGD97179.1 - 0.14 12.6 0.0 0.15 12.5 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1636) DUF4588 PF15251.6 EGD97180.1 - 5.5e-05 23.1 0.2 5.5e-05 23.1 0.2 2.0 2 1 0 2 2 2 1 Domain of unknown function (DUF4588) SNF2_N PF00176.23 EGD97181.1 - 2e-75 253.7 0.1 3.7e-75 252.8 0.1 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain SLIDE PF09111.10 EGD97181.1 - 6.3e-44 148.6 0.9 2.3e-43 146.8 0.9 2.1 1 0 0 1 1 1 1 SLIDE HAND PF09110.11 EGD97181.1 - 1.1e-30 106.7 4.8 1.1e-30 106.7 4.8 3.9 3 0 0 3 3 3 1 HAND Helicase_C PF00271.31 EGD97181.1 - 6.1e-18 65.2 0.7 2.4e-17 63.2 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EGD97181.1 - 1e-10 41.9 0.9 6.6e-10 39.3 0.0 2.9 4 0 0 4 4 3 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 EGD97181.1 - 1.2e-06 27.9 0.1 5.5e-06 25.8 0.0 2.1 2 0 0 2 2 2 1 Class II histone deacetylase complex subunits 2 and 3 SWI2_SNF2 PF18766.1 EGD97181.1 - 0.0003 20.5 0.0 0.0019 17.9 0.0 2.4 2 0 0 2 2 2 1 SWI2/SNF2 ATPase DEAD PF00270.29 EGD97181.1 - 0.00055 19.7 0.0 0.0015 18.3 0.0 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase DUF1086 PF06461.11 EGD97181.1 - 0.012 15.5 0.1 0.034 14.0 0.1 1.7 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1086) Ku_C PF03730.14 EGD97181.1 - 0.015 16.0 0.4 0.015 16.0 0.4 3.6 4 0 0 4 4 2 0 Ku70/Ku80 C-terminal arm AAA_14 PF13173.6 EGD97181.1 - 0.024 14.7 0.0 0.14 12.2 0.0 2.4 1 0 0 1 1 1 0 AAA domain DEAD_2 PF06733.15 EGD97181.1 - 0.037 13.7 0.0 0.08 12.6 0.0 1.5 1 0 0 1 1 1 0 DEAD_2 Myb_DNA-binding PF00249.31 EGD97181.1 - 0.13 12.5 0.0 4 7.7 0.0 2.8 2 0 0 2 2 2 0 Myb-like DNA-binding domain Occludin_ELL PF07303.13 EGD97181.1 - 0.16 12.7 3.2 0.64 10.8 3.2 2.1 1 0 0 1 1 1 0 Occludin homology domain ArdA PF07275.11 EGD97181.1 - 0.68 10.5 4.2 0.42 11.2 0.3 2.6 3 0 0 3 3 3 0 Antirestriction protein (ArdA) SpoU_methylase PF00588.19 EGD97182.1 - 5.6e-25 88.2 0.0 1.2e-24 87.1 0.0 1.6 1 1 0 1 1 1 1 SpoU rRNA Methylase family SpoU_sub_bind PF08032.12 EGD97182.1 - 4.7e-09 36.4 0.0 9e-09 35.5 0.0 1.5 1 0 0 1 1 1 1 RNA 2'-O ribose methyltransferase substrate binding zf-PHD-like PF15446.6 EGD97183.1 - 5.7e-64 214.8 11.0 1.2e-63 213.7 11.0 1.6 1 0 0 1 1 1 1 PHD/FYVE-zinc-finger like domain SNF2_N PF00176.23 EGD97183.1 - 3e-32 111.7 1.6 4.6e-32 111.1 1.6 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain zf-CCCH_6 PF18585.1 EGD97183.1 - 7e-25 86.7 0.9 7e-25 86.7 0.9 2.2 2 0 0 2 2 2 1 Chromatin remodeling factor Mit1 C-terminal Zn finger 2 Helicase_C PF00271.31 EGD97183.1 - 6.3e-18 65.1 0.0 1.8e-17 63.7 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HDA2-3 PF11496.8 EGD97183.1 - 2.4e-09 36.8 2.3 7.3e-09 35.2 2.3 1.7 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 Chromo PF00385.24 EGD97183.1 - 3.9e-06 26.7 3.1 0.018 15.0 0.5 2.8 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain PHD PF00628.29 EGD97183.1 - 1.3e-05 25.0 2.6 1.3e-05 25.0 2.6 3.7 2 1 0 2 2 2 1 PHD-finger ResIII PF04851.15 EGD97183.1 - 0.0027 17.7 0.0 0.018 15.0 0.0 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DUF1087 PF06465.13 EGD97183.1 - 0.0057 16.7 0.8 0.017 15.1 0.1 2.1 2 0 0 2 2 2 1 Domain of Unknown Function (DUF1087) DEAD_2 PF06733.15 EGD97183.1 - 0.023 14.3 0.1 0.09 12.4 0.0 2.0 2 0 0 2 2 2 0 DEAD_2 SnAC PF14619.6 EGD97183.1 - 0.056 14.0 5.0 0.2 12.3 0.3 3.5 3 0 0 3 3 3 0 Snf2-ATP coupling, chromatin remodelling complex FANCL_C PF11793.8 EGD97183.1 - 0.67 10.2 3.4 2.4 8.4 3.4 2.0 1 0 0 1 1 1 0 FANCL C-terminal domain Zf_RING PF16744.5 EGD97183.1 - 4.6 7.4 11.6 9.5 6.4 0.3 3.3 3 0 0 3 3 3 0 KIAA1045 RING finger HMG-CoA_red PF00368.18 EGD97184.1 - 1.7e-136 455.1 10.6 2.9e-136 454.3 10.6 1.4 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A reductase HPIH PF13323.6 EGD97184.1 - 6.7e-46 156.0 0.0 1.2e-45 155.1 0.0 1.5 1 0 0 1 1 1 1 N-terminal domain with HPIH motif Sterol-sensing PF12349.8 EGD97184.1 - 8.6e-13 48.4 4.8 1e-11 44.9 4.8 2.4 1 1 0 1 1 1 1 Sterol-sensing domain of SREBP cleavage-activation Patched PF02460.18 EGD97184.1 - 2.7e-05 22.5 2.3 2.7e-05 22.5 2.3 1.3 2 0 0 2 2 2 1 Patched family CVNH PF08881.10 EGD97185.1 - 1.7e-24 86.4 0.5 1.9e-24 86.3 0.5 1.0 1 0 0 1 1 1 1 CVNH domain Protamine_P2 PF00841.19 EGD97186.1 - 5.5 7.6 20.9 0.41 11.2 14.4 2.2 1 1 1 2 2 2 0 Sperm histone P2 GIT_SHD PF08518.11 EGD97187.1 - 4.2e-22 77.4 10.1 1.9e-11 43.3 1.2 2.8 2 0 0 2 2 2 2 Spa2 homology domain (SHD) of GIT APG6_N PF17675.1 EGD97187.1 - 0.0048 17.4 19.9 0.0048 17.4 19.9 3.7 3 1 1 4 4 4 1 Apg6 coiled-coil region DUF3450 PF11932.8 EGD97187.1 - 2 7.7 23.5 1.5 8.1 2.9 3.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) zf-C4H2 PF10146.9 EGD97187.1 - 3.9 7.7 24.4 23 5.2 6.8 3.7 2 1 0 2 2 2 0 Zinc finger-containing protein Phage_Nu1 PF07471.12 EGD97187.1 - 9.7 5.9 10.9 0.3 10.8 2.0 2.6 1 1 1 2 2 2 0 Phage DNA packaging protein Nu1 Pro_isomerase PF00160.21 EGD97188.1 - 1.4e-37 129.4 0.2 1.7e-37 129.1 0.2 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD RNase_PH PF01138.21 EGD97189.1 - 2e-28 99.5 0.3 4.2e-28 98.5 0.2 1.6 2 0 0 2 2 2 1 3' exoribonuclease family, domain 1 AIRC PF00731.20 EGD97189.1 - 0.07 12.7 0.0 0.18 11.4 0.0 1.6 1 0 0 1 1 1 0 AIR carboxylase SNF2_N PF00176.23 EGD97190.1 - 3.1e-52 177.4 0.0 5.2e-52 176.7 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain VIGSSK PF14773.6 EGD97190.1 - 5.5e-25 87.3 0.4 1.6e-24 85.8 0.4 1.8 1 0 0 1 1 1 1 Helicase-associated putative binding domain, C-terminal Helicase_C PF00271.31 EGD97190.1 - 3e-19 69.4 0.0 1.1e-18 67.6 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ERCC3_RAD25_C PF16203.5 EGD97190.1 - 1.9e-08 33.9 0.0 3.6e-08 32.9 0.0 1.4 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase ResIII PF04851.15 EGD97190.1 - 4e-08 33.4 0.2 1.9e-07 31.2 0.0 2.2 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EGD97190.1 - 0.0011 18.7 0.0 0.0024 17.7 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase DUF1018 PF06252.12 EGD97190.1 - 0.029 15.4 0.1 0.098 13.7 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1018) Ssu72 PF04722.13 EGD97191.1 - 3.8e-82 274.5 0.0 4.4e-82 274.3 0.0 1.0 1 0 0 1 1 1 1 Ssu72-like protein CAP_N PF01213.19 EGD97191.1 - 4.5 6.7 5.9 7.5 5.9 5.9 1.3 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal zf-CHCC PF10276.9 EGD97192.1 - 0.003 17.6 3.9 0.059 13.4 0.3 2.9 2 0 0 2 2 2 1 Zinc-finger domain PyrI_C PF02748.15 EGD97192.1 - 0.049 13.5 0.4 8.7 6.3 0.1 2.5 2 0 0 2 2 2 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-CCHC PF00098.23 EGD97192.1 - 0.05 13.7 3.3 0.1 12.7 3.3 1.6 1 0 0 1 1 1 0 Zinc knuckle RAP1 PF07218.11 EGD97192.1 - 0.2 9.9 4.6 0.3 9.3 4.6 1.3 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) zf-BED PF02892.15 EGD97192.1 - 0.55 10.3 3.7 11 6.2 0.1 2.5 2 0 0 2 2 2 0 BED zinc finger ATP-synt_G PF04718.15 EGD97192.1 - 0.97 10.3 3.0 1.4 9.8 1.1 2.2 2 0 0 2 2 2 0 Mitochondrial ATP synthase g subunit Trypan_PARP PF05887.11 EGD97192.1 - 2.8 7.9 11.5 12 5.8 6.0 2.6 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) Acyl-CoA_dh_1 PF00441.24 EGD97193.1 - 3.5e-18 66.3 0.1 1.6e-17 64.1 0.1 2.0 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain AidB_N PF18158.1 EGD97193.1 - 4.1e-12 46.3 0.0 8.7e-12 45.2 0.0 1.5 1 0 0 1 1 1 1 Adaptive response protein AidB N-terminal domain Acyl-CoA_dh_M PF02770.19 EGD97193.1 - 7.7e-10 38.9 0.0 1.8e-09 37.7 0.0 1.7 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Oxysterol_BP PF01237.18 EGD97194.1 - 5.3e-88 295.4 0.1 1e-77 261.5 0.0 2.0 1 1 1 2 2 2 2 Oxysterol-binding protein DUF3605 PF12239.8 EGD97195.1 - 4.6e-52 176.4 1.7 6.3e-52 176.0 1.7 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3605) DUF4116 PF13475.6 EGD97195.1 - 0.11 12.3 0.0 0.29 10.9 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4116) Isochorismatase PF00857.20 EGD97196.1 - 2.2e-25 89.8 0.0 4.1e-24 85.7 0.0 2.0 1 1 0 1 1 1 1 Isochorismatase family Hist_deacetyl PF00850.19 EGD97197.1 - 8.7e-78 261.9 0.0 1.3e-77 261.3 0.0 1.3 1 0 0 1 1 1 1 Histone deacetylase domain ING PF12998.7 EGD97198.1 - 1.7e-22 79.9 3.6 2.8e-22 79.2 3.6 1.4 1 0 0 1 1 1 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.29 EGD97198.1 - 2.7e-05 24.0 9.7 5e-05 23.1 9.7 1.5 1 0 0 1 1 1 1 PHD-finger TFIIA PF03153.13 EGD97198.1 - 0.0065 16.5 6.7 0.0097 15.9 6.7 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit zf-HC5HC2H PF13771.6 EGD97198.1 - 0.032 14.5 0.3 0.074 13.3 0.3 1.6 1 0 0 1 1 1 0 PHD-like zinc-binding domain Prominin PF05478.11 EGD97198.1 - 0.056 11.4 0.5 0.13 10.2 0.3 1.6 2 0 0 2 2 2 0 Prominin PHD_2 PF13831.6 EGD97198.1 - 0.54 9.9 3.8 1.1 8.8 3.8 1.5 1 0 0 1 1 1 0 PHD-finger Hamartin PF04388.12 EGD97198.1 - 5.4 5.5 11.5 8.1 5.0 11.5 1.2 1 0 0 1 1 1 0 Hamartin protein RNA_pol_Rpc34 PF05158.12 EGD97199.1 - 3.6e-101 338.9 0.0 4.4e-101 338.6 0.0 1.0 1 0 0 1 1 1 1 RNA polymerase Rpc34 subunit Rrf2 PF02082.20 EGD97199.1 - 0.18 12.1 0.1 0.86 10.0 0.0 2.0 2 0 0 2 2 2 0 Transcriptional regulator TPR_1 PF00515.28 EGD97200.1 - 8e-38 126.8 25.9 2.2e-05 24.1 0.0 9.7 9 0 0 9 9 9 8 Tetratricopeptide repeat STI1 PF17830.1 EGD97200.1 - 1e-34 118.2 3.3 4.8e-20 71.2 0.6 3.0 2 0 0 2 2 2 2 STI1 domain TPR_2 PF07719.17 EGD97200.1 - 2.7e-29 98.9 25.3 0.00026 20.9 0.1 10.0 9 0 0 9 9 9 8 Tetratricopeptide repeat TPR_11 PF13414.6 EGD97200.1 - 2e-17 62.6 18.3 0.0076 15.9 0.1 7.9 6 1 2 8 8 8 5 TPR repeat TPR_19 PF14559.6 EGD97200.1 - 1.3e-14 54.4 22.3 0.0019 18.6 0.2 6.8 6 1 1 7 7 7 4 Tetratricopeptide repeat TPR_8 PF13181.6 EGD97200.1 - 6.3e-14 51.0 23.4 0.01 16.0 0.1 8.9 9 0 0 9 9 8 5 Tetratricopeptide repeat TPR_9 PF13371.6 EGD97200.1 - 2.9e-10 40.1 4.6 0.0019 18.3 0.1 4.8 3 2 1 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 EGD97200.1 - 1.6e-09 38.3 17.9 0.014 16.1 0.3 6.7 3 3 4 8 8 8 4 Tetratricopeptide repeat TPR_12 PF13424.6 EGD97200.1 - 6.6e-09 35.9 20.1 0.00021 21.5 0.3 6.4 5 3 2 7 7 7 3 Tetratricopeptide repeat TPR_14 PF13428.6 EGD97200.1 - 1.2e-08 35.1 23.1 1.8 9.6 0.2 9.8 8 2 2 10 10 10 3 Tetratricopeptide repeat TPR_17 PF13431.6 EGD97200.1 - 1.7e-07 31.2 9.8 0.12 12.9 0.0 7.0 6 1 0 6 6 6 2 Tetratricopeptide repeat TPR_7 PF13176.6 EGD97200.1 - 4e-07 29.6 12.7 0.0073 16.3 0.0 6.6 8 0 0 8 8 7 2 Tetratricopeptide repeat TPR_10 PF13374.6 EGD97200.1 - 0.00042 20.1 11.0 0.32 10.9 0.1 6.5 6 1 1 7 7 7 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EGD97200.1 - 0.0019 18.4 8.7 0.24 11.6 0.2 3.9 3 0 0 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 EGD97200.1 - 0.039 14.6 21.7 1.3 9.8 0.0 8.5 9 0 0 9 9 9 0 Tetratricopeptide repeat SPESP1 PF15754.5 EGD97200.1 - 0.074 12.2 0.6 0.16 11.1 0.6 1.5 1 0 0 1 1 1 0 Sperm equatorial segment protein 1 SHNi-TPR PF10516.9 EGD97200.1 - 5 6.7 9.3 20 4.7 0.1 5.3 6 0 0 6 6 6 0 SHNi-TPR C2 PF00168.30 EGD97201.1 - 3.1e-72 239.4 0.3 5.1e-19 68.5 0.0 5.5 5 0 0 5 5 5 5 C2 domain SMP_LBD PF17047.5 EGD97201.1 - 0.0087 15.5 0.0 0.063 12.7 0.0 2.3 2 1 0 2 2 2 1 Synaptotagmin-like mitochondrial-lipid-binding domain FIVAR PF07554.13 EGD97202.1 - 0.11 13.3 0.0 0.17 12.7 0.0 1.3 1 0 0 1 1 1 0 FIVAR domain RRM_1 PF00076.22 EGD97203.1 - 2.1e-16 59.5 0.0 6.9e-12 45.0 0.0 3.2 3 1 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 EGD97203.1 - 0.0047 17.0 0.0 0.28 11.3 0.0 2.5 2 0 0 2 2 2 1 Limkain b1 UDPGP PF01704.18 EGD97204.1 - 2.8e-189 629.0 0.0 3.3e-189 628.8 0.0 1.0 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase PilO PF04350.13 EGD97204.1 - 0.06 13.5 0.0 0.15 12.2 0.0 1.6 1 0 0 1 1 1 0 Pilus assembly protein, PilO zf-CCCH PF00642.24 EGD97206.1 - 3.3e-08 33.2 20.0 3e-07 30.2 2.5 3.1 3 0 0 3 3 3 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) RRM_1 PF00076.22 EGD97206.1 - 0.00044 20.0 0.0 0.00068 19.4 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf_CCCH_4 PF18345.1 EGD97206.1 - 0.0058 16.7 3.3 0.0058 16.7 3.3 3.3 3 0 0 3 3 3 1 Zinc finger domain Torus PF16131.5 EGD97206.1 - 0.0087 16.7 3.1 0.5 11.1 0.2 2.5 2 0 0 2 2 2 2 Torus domain DUF4185 PF13810.6 EGD97207.1 - 0.00038 19.8 0.2 0.00053 19.3 0.2 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4185) Amidase PF01425.21 EGD97208.1 - 3.2e-87 293.4 0.0 5.6e-87 292.6 0.0 1.4 1 1 0 1 1 1 1 Amidase SepZ PF06066.11 EGD97208.1 - 0.075 13.3 0.2 0.17 12.1 0.2 1.5 1 0 0 1 1 1 0 SepZ MFS_1 PF07690.16 EGD97209.1 - 2.6e-15 56.2 25.3 3.2e-15 55.9 24.0 1.8 2 1 0 2 2 2 1 Major Facilitator Superfamily PhyH PF05721.13 EGD97210.1 - 9.7e-30 104.4 0.0 1.3e-29 104.0 0.0 1.1 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) HNH_2 PF13391.6 EGD97212.1 - 8.1e-13 48.3 0.1 1.7e-12 47.3 0.1 1.5 1 0 0 1 1 1 1 HNH endonuclease Epimerase PF01370.21 EGD97213.1 - 1.2e-05 24.9 0.0 1.7e-05 24.4 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Zn_clus PF00172.18 EGD97214.1 - 1.6e-05 24.9 12.1 2.9e-05 24.1 12.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain FYVE PF01363.21 EGD97216.1 - 5.2e-17 61.7 6.0 5.2e-17 61.7 6.0 3.2 3 1 0 3 3 3 1 FYVE zinc finger zf-RING_2 PF13639.6 EGD97216.1 - 1.4e-07 31.7 4.7 1.4e-07 31.7 4.7 3.5 3 0 0 3 3 3 1 Ring finger domain zf-C3HC4_2 PF13923.6 EGD97216.1 - 5.4e-06 26.1 3.7 5.4e-06 26.1 3.7 3.9 3 1 1 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EGD97216.1 - 0.00018 21.2 4.9 0.00018 21.2 4.9 3.4 3 0 0 3 3 3 1 RING-like zinc finger zf-rbx1 PF12678.7 EGD97216.1 - 0.0012 19.1 4.2 0.0012 19.1 4.2 3.8 4 0 0 4 4 4 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 EGD97216.1 - 0.0034 17.2 4.1 0.0034 17.2 4.1 3.4 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) Zn-C2H2_12 PF18112.1 EGD97216.1 - 0.04 14.4 7.2 0.63 10.6 1.2 3.0 2 0 0 2 2 2 0 Autophagy receptor zinc finger-C2H2 domain FYVE_2 PF02318.16 EGD97216.1 - 0.74 10.0 8.2 0.11 12.7 0.6 2.4 2 0 0 2 2 2 0 FYVE-type zinc finger TRP PF06011.12 EGD97217.1 - 7.8e-40 136.9 20.5 9e-38 130.1 20.5 2.2 1 1 0 1 1 1 1 Transient receptor potential (TRP) ion channel TRP_N PF14558.6 EGD97217.1 - 1.6e-15 57.7 0.1 2.4e-15 57.1 0.1 1.3 1 0 0 1 1 1 1 ML-like domain DUF4381 PF14316.6 EGD97217.1 - 6.4 7.0 6.9 15 5.9 0.9 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4381) Strabismus PF06638.11 EGD97217.1 - 8.2 4.9 6.3 13 4.3 6.3 1.1 1 0 0 1 1 1 0 Strabismus protein Cys_Met_Meta_PP PF01053.20 EGD97220.1 - 3.2e-61 207.0 0.0 1.4e-60 204.9 0.0 2.0 1 1 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 EGD97220.1 - 0.0014 17.7 0.0 0.0024 16.9 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V DUF2073 PF09846.9 EGD97220.1 - 0.0096 15.8 0.0 2.6 8.0 0.0 2.3 2 0 0 2 2 2 2 Uncharacterized protein conserved in archaea (DUF2073) Aminotran_1_2 PF00155.21 EGD97220.1 - 0.067 12.4 0.0 0.14 11.3 0.0 1.5 2 0 0 2 2 2 0 Aminotransferase class I and II ThiS PF02597.20 EGD97221.1 - 0.0009 19.8 0.0 0.0084 16.7 0.0 1.9 1 1 0 1 1 1 1 ThiS family GFA PF04828.14 EGD97222.1 - 2.3e-23 82.3 0.6 2.3e-23 82.3 0.6 1.5 2 0 0 2 2 2 1 Glutathione-dependent formaldehyde-activating enzyme INPP5B_PH PF16776.5 EGD97222.1 - 0.076 12.7 0.0 0.11 12.2 0.0 1.2 1 0 0 1 1 1 0 Type II inositol 1,4,5-trisphosphate 5-phosphatase PH domain Zn_clus PF00172.18 EGD97223.1 - 1.9e-08 34.3 4.5 3.6e-08 33.4 4.5 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EGD97223.1 - 3.1e-06 26.4 0.0 6.6e-06 25.3 0.0 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain ABC2_membrane PF01061.24 EGD97224.1 - 9.2e-27 93.8 26.9 1.3e-26 93.3 26.9 1.2 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.27 EGD97224.1 - 1.7e-25 90.2 0.3 5.1e-25 88.6 0.1 1.8 2 0 0 2 2 2 1 ABC transporter AAA_21 PF13304.6 EGD97224.1 - 2.2e-07 31.0 0.2 0.0083 16.0 0.0 2.3 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 EGD97224.1 - 6.3e-06 26.2 0.2 3.1e-05 23.9 0.0 2.0 2 0 0 2 2 2 1 RsgA GTPase SMC_N PF02463.19 EGD97224.1 - 3.7e-05 23.3 0.1 8.8e-05 22.0 0.1 1.5 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 EGD97224.1 - 0.00024 21.6 0.3 0.00068 20.1 0.0 1.9 2 0 0 2 2 2 1 AAA ATPase domain AAA PF00004.29 EGD97224.1 - 0.0022 18.4 0.0 0.034 14.6 0.0 2.4 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.6 EGD97224.1 - 0.0036 16.9 0.0 0.0082 15.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 EGD97224.1 - 0.0039 16.3 0.0 0.0075 15.4 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_22 PF13401.6 EGD97224.1 - 0.0062 16.8 0.1 0.019 15.3 0.1 1.7 1 1 0 1 1 1 1 AAA domain Rad17 PF03215.15 EGD97224.1 - 0.007 16.3 0.0 0.014 15.3 0.0 1.5 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_30 PF13604.6 EGD97224.1 - 0.0086 15.8 0.0 0.015 15.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 EGD97224.1 - 0.0088 15.8 0.2 0.019 14.7 0.2 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain ABC2_membrane_3 PF12698.7 EGD97224.1 - 0.011 14.8 23.3 0.018 14.2 23.3 1.3 1 0 0 1 1 1 0 ABC-2 family transporter protein AAA_13 PF13166.6 EGD97224.1 - 0.012 14.4 4.5 0.012 14.3 0.1 2.3 3 0 0 3 3 3 0 AAA domain cobW PF02492.19 EGD97224.1 - 0.012 15.3 0.0 0.025 14.2 0.0 1.5 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_18 PF13238.6 EGD97224.1 - 0.014 15.9 0.0 0.039 14.5 0.0 1.8 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 EGD97224.1 - 0.015 15.0 0.0 0.034 13.9 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_28 PF13521.6 EGD97224.1 - 0.021 15.1 0.0 0.039 14.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 EGD97224.1 - 0.031 14.4 0.0 0.065 13.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 EGD97224.1 - 0.053 13.0 0.0 0.1 12.1 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region NACHT PF05729.12 EGD97224.1 - 0.063 13.2 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 NACHT domain AAA_23 PF13476.6 EGD97224.1 - 0.078 13.5 0.9 0.25 11.8 0.2 2.0 2 1 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 EGD97224.1 - 0.09 13.2 0.0 0.56 10.6 0.0 2.2 2 0 0 2 2 2 0 RNA helicase ATPase_2 PF01637.18 EGD97224.1 - 0.11 12.4 0.0 0.23 11.4 0.0 1.5 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_19 PF13245.6 EGD97224.1 - 0.17 12.2 0.1 0.34 11.2 0.1 1.6 1 1 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 EGD97224.1 - 0.19 11.8 0.5 0.45 10.6 0.1 1.8 2 0 0 2 2 1 0 50S ribosome-binding GTPase tRNA-synt_2 PF00152.20 EGD97225.1 - 9.9e-88 294.2 0.0 1.3e-87 293.8 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 EGD97225.1 - 4.7e-05 23.3 0.0 8.5e-05 22.5 0.0 1.4 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2b PF00587.25 EGD97225.1 - 0.061 13.3 0.0 0.11 12.5 0.0 1.3 1 0 0 1 1 1 0 tRNA synthetase class II core domain (G, H, P, S and T) tRNA-synt_2d PF01409.20 EGD97225.1 - 0.17 11.4 0.0 0.51 9.8 0.0 1.8 1 0 0 1 1 1 0 tRNA synthetases class II core domain (F) LRRCT PF01463.24 EGD97226.1 - 0.26 11.9 1.7 8.5 7.2 0.0 2.9 3 0 0 3 3 3 0 Leucine rich repeat C-terminal domain PUD PF03714.14 EGD97227.1 - 0.066 14.1 0.7 15 6.6 0.0 2.4 2 0 0 2 2 2 0 Bacterial pullanase-associated domain Oxidored_q2 PF00420.24 EGD97227.1 - 0.17 11.5 0.0 0.17 11.5 0.0 2.6 3 0 0 3 3 3 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L PEP_mutase PF13714.6 EGD97228.1 - 7e-67 225.4 1.1 7.9e-67 225.2 1.1 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase ABC_tran PF00005.27 EGD97229.1 - 9.3e-49 165.5 0.0 1.8e-31 109.4 0.0 2.8 2 1 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 EGD97229.1 - 2.4e-39 135.6 30.0 1.6e-25 90.3 9.8 3.5 3 1 0 3 3 3 2 ABC transporter transmembrane region SMC_N PF02463.19 EGD97229.1 - 5e-12 45.7 0.0 0.0059 16.1 0.0 4.3 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 EGD97229.1 - 8.6e-08 32.9 0.5 4.2e-05 24.1 0.1 2.4 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 EGD97229.1 - 3.5e-05 24.1 0.0 1.5 9.1 0.0 3.4 3 0 0 3 3 3 2 AAA domain RsgA_GTPase PF03193.16 EGD97229.1 - 0.00029 20.8 0.0 0.67 9.8 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 EGD97229.1 - 0.00033 20.7 0.2 0.055 13.6 0.0 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_29 PF13555.6 EGD97229.1 - 0.00037 20.2 3.8 0.072 12.8 0.2 3.0 3 0 0 3 3 3 2 P-loop containing region of AAA domain T2SSE PF00437.20 EGD97229.1 - 0.00046 19.3 0.0 0.052 12.6 0.0 2.2 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_16 PF13191.6 EGD97229.1 - 0.00088 19.7 0.4 1.3 9.3 0.0 3.2 3 0 0 3 3 3 2 AAA ATPase domain AAA_21 PF13304.6 EGD97229.1 - 0.0043 16.9 0.2 8.8 6.0 0.0 3.3 3 0 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system IstB_IS21 PF01695.17 EGD97229.1 - 0.0065 16.2 0.3 0.67 9.7 0.0 3.1 3 0 0 3 3 3 1 IstB-like ATP binding protein Zeta_toxin PF06414.12 EGD97229.1 - 0.015 14.6 0.1 3.2 7.0 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin DUF87 PF01935.17 EGD97229.1 - 0.019 15.0 4.7 0.83 9.7 0.1 2.8 3 0 0 3 3 3 0 Helicase HerA, central domain AAA_15 PF13175.6 EGD97229.1 - 0.057 13.1 0.2 5.9 6.5 0.2 2.2 2 0 0 2 2 2 0 AAA ATPase domain AAA_30 PF13604.6 EGD97229.1 - 0.089 12.5 0.5 20 4.8 0.1 3.0 3 0 0 3 3 3 0 AAA domain MeaB PF03308.16 EGD97229.1 - 0.091 11.7 0.0 0.18 10.8 0.0 1.4 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB DUF2075 PF09848.9 EGD97229.1 - 0.091 12.0 0.1 1.2 8.3 0.0 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) CbiA PF01656.23 EGD97229.1 - 0.19 11.8 0.7 26 4.9 0.5 2.7 2 0 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain PhoD PF09423.10 EGD97230.1 - 6.2e-113 377.4 0.9 7.5e-113 377.1 0.9 1.1 1 0 0 1 1 1 1 PhoD-like phosphatase PhoD_N PF16655.5 EGD97230.1 - 1.7e-32 111.8 0.0 4.2e-32 110.5 0.0 1.7 1 0 0 1 1 1 1 PhoD-like phosphatase, N-terminal domain Pur_ac_phosph_N PF16656.5 EGD97230.1 - 8.2e-05 23.1 0.1 0.00023 21.7 0.1 1.9 1 0 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain LigD_N PF13298.6 EGD97231.1 - 3.1e-35 120.6 0.1 5.7e-35 119.8 0.1 1.4 1 0 0 1 1 1 1 DNA polymerase Ligase (LigD) Sulf_transp PF04143.14 EGD97232.1 - 1.1e-06 28.5 17.5 2.3e-05 24.1 3.5 3.3 3 0 0 3 3 3 3 Sulphur transport Peptidase_M28 PF04389.17 EGD97233.1 - 1.9e-29 102.8 0.0 3.6e-29 101.9 0.0 1.5 1 1 0 1 1 1 1 Peptidase family M28 Rhodanese PF00581.20 EGD97236.1 - 1.8e-07 31.7 0.0 2.5e-07 31.2 0.0 1.2 1 0 0 1 1 1 1 Rhodanese-like domain HTH_22 PF13309.6 EGD97236.1 - 0.082 13.0 0.0 0.16 12.0 0.0 1.5 1 0 0 1 1 1 0 HTH domain MutS_V PF00488.21 EGD97237.1 - 9.8e-67 224.6 0.1 1.8e-66 223.8 0.1 1.5 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 EGD97237.1 - 1.8e-42 145.7 0.1 4.1e-42 144.6 0.1 1.7 1 0 0 1 1 1 1 MutS domain III MutS_I PF01624.20 EGD97237.1 - 3.8e-33 114.1 0.1 1.7e-32 112.0 0.1 2.1 2 0 0 2 2 2 1 MutS domain I MutS_IV PF05190.18 EGD97237.1 - 1.7e-15 57.1 2.4 4e-15 55.9 2.4 1.7 1 0 0 1 1 1 1 MutS family domain IV MutS_II PF05188.17 EGD97237.1 - 2.7e-13 50.4 0.0 9.4e-13 48.6 0.0 2.0 1 0 0 1 1 1 1 MutS domain II SPT6_acidic PF14632.6 EGD97237.1 - 0.0055 17.3 9.4 0.0055 17.3 9.4 3.3 3 1 1 4 4 2 1 Acidic N-terminal SPT6 AAA_27 PF13514.6 EGD97237.1 - 0.018 14.6 0.0 0.047 13.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 EGD97237.1 - 0.025 15.1 0.1 0.025 15.1 0.1 3.2 3 0 0 3 3 3 0 AAA domain AAA_29 PF13555.6 EGD97237.1 - 0.068 12.9 0.0 0.14 12.0 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_21 PF13304.6 EGD97237.1 - 0.64 9.8 4.4 0.14 11.9 0.2 2.1 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system Spem1 PF15670.5 EGD97237.1 - 2.4 7.7 6.2 4.9 6.6 6.2 1.5 1 0 0 1 1 1 0 Spermatid maturation protein 1 tRNA-synt_1b PF00579.25 EGD97238.1 - 1.7e-72 244.2 0.0 2.3e-72 243.8 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) TyrRSs_C PF16714.5 EGD97238.1 - 9e-44 148.1 0.0 1.8e-43 147.2 0.0 1.5 1 0 0 1 1 1 1 Tyrosyl-tRNA synthetase C-terminal domain Raffinose_syn PF05691.12 EGD97239.1 - 3.4e-53 180.6 1.6 1.6e-48 165.1 1.4 4.2 3 1 0 3 3 3 2 Raffinose synthase or seed imbibition protein Sip1 Melibiase PF02065.18 EGD97239.1 - 0.0042 16.1 0.2 0.0073 15.3 0.2 1.3 1 0 0 1 1 1 1 Melibiase SnAC PF14619.6 EGD97239.1 - 0.034 14.8 0.0 0.15 12.7 0.0 2.0 2 0 0 2 2 2 0 Snf2-ATP coupling, chromatin remodelling complex DUF1697 PF08002.11 EGD97239.1 - 0.19 12.2 0.6 0.45 11.0 0.2 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1697) Aldedh PF00171.22 EGD97240.1 - 5.6e-165 549.3 0.4 6.4e-165 549.1 0.4 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family RRN9 PF10680.9 EGD97241.1 - 2.9e-23 81.9 0.5 8e-23 80.5 0.1 2.1 2 0 0 2 2 2 1 RNA polymerase I specific transcription initiation factor Pescadillo_N PF06732.11 EGD97242.1 - 1.6e-123 411.6 0.0 1.6e-123 411.6 0.0 2.2 2 0 0 2 2 2 1 Pescadillo N-terminus BRCT_2 PF16589.5 EGD97242.1 - 0.0019 18.6 0.0 0.0089 16.4 0.0 2.2 1 1 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 EGD97242.1 - 0.043 14.2 0.0 0.55 10.6 0.0 2.7 2 1 0 2 2 2 0 BRCA1 C Terminus (BRCT) domain PIG-U PF06728.13 EGD97243.1 - 7.7e-119 397.2 24.2 8.8e-119 397.0 24.2 1.0 1 0 0 1 1 1 1 GPI transamidase subunit PIG-U Acetyltransf_1 PF00583.25 EGD97244.1 - 1.8e-12 47.5 0.0 2.5e-12 47.1 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EGD97244.1 - 1.7e-09 37.6 0.0 5.2e-09 36.1 0.0 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EGD97244.1 - 6e-09 36.2 0.0 9.1e-09 35.6 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EGD97244.1 - 2.7e-05 24.0 0.0 4.9e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_4 PF13420.7 EGD97244.1 - 0.0035 17.5 0.0 0.0061 16.7 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 EGD97244.1 - 0.02 15.5 0.0 0.03 15.0 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain HIG_1_N PF04588.13 EGD97245.1 - 7.8e-30 102.9 0.6 1.1e-29 102.4 0.6 1.2 1 0 0 1 1 1 1 Hypoxia induced protein conserved region PALP PF00291.25 EGD97246.1 - 2.1e-78 263.7 0.4 2.6e-78 263.4 0.4 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Thr_dehydrat_C PF00585.18 EGD97246.1 - 9.5e-42 140.7 0.0 1.8e-19 69.3 0.0 2.4 2 0 0 2 2 2 2 C-terminal regulatory domain of Threonine dehydratase Ribosomal_L36 PF00444.18 EGD97247.1 - 4.6e-21 74.7 9.8 7.2e-21 74.1 9.8 1.3 1 0 0 1 1 1 1 Ribosomal protein L36 GTP_EFTU PF00009.27 EGD97248.1 - 2.3e-58 197.0 0.4 4.1e-58 196.1 0.4 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 EGD97248.1 - 9.4e-34 115.8 0.0 2.2e-33 114.6 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_II PF14492.6 EGD97248.1 - 2.7e-32 110.7 0.0 5.6e-32 109.7 0.0 1.6 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.24 EGD97248.1 - 1.1e-24 86.3 0.0 2.6e-24 85.1 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 EGD97248.1 - 1.6e-11 44.4 0.0 4.6e-11 42.9 0.0 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 2 RF3_C PF16658.5 EGD97248.1 - 1.5e-05 24.8 0.0 3.4e-05 23.7 0.0 1.6 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain ATP_bind_1 PF03029.17 EGD97248.1 - 0.041 13.7 0.1 0.15 11.8 0.1 2.0 1 1 0 1 1 1 0 Conserved hypothetical ATP binding protein MMR_HSR1 PF01926.23 EGD97248.1 - 0.16 12.0 0.0 0.38 10.9 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase Abhydrolase_6 PF12697.7 EGD97249.1 - 6.5e-13 49.8 0.1 1.2e-12 49.0 0.1 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EGD97249.1 - 3.7e-08 32.9 0.0 7.8e-08 31.9 0.0 1.6 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EGD97249.1 - 1.4e-07 31.5 0.0 1.7e-07 31.2 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_3 PF07859.13 EGD97249.1 - 0.00018 21.5 0.0 0.00027 20.9 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold DUF818 PF05677.12 EGD97249.1 - 0.0017 17.4 0.0 0.0027 16.7 0.0 1.2 1 0 0 1 1 1 1 Chlamydia CHLPS protein (DUF818) Peptidase_S9 PF00326.21 EGD97249.1 - 0.085 12.3 0.0 0.22 11.0 0.0 1.6 2 0 0 2 2 2 0 Prolyl oligopeptidase family TLD PF07534.16 EGD97251.1 - 1.3e-20 74.1 0.0 2.2e-20 73.3 0.0 1.4 1 0 0 1 1 1 1 TLD DUF1773 PF08593.10 EGD97251.1 - 0.00073 20.5 0.5 0.0029 18.6 0.5 2.1 1 1 0 1 1 1 1 Domain of unknown function NMT_C PF02799.15 EGD97252.1 - 1e-89 299.6 0.3 1.6e-89 299.0 0.3 1.3 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain NMT PF01233.19 EGD97252.1 - 1.3e-71 239.6 0.0 2.3e-71 238.8 0.0 1.4 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain Acetyltransf_9 PF13527.7 EGD97252.1 - 7e-05 22.9 0.0 0.00021 21.4 0.0 1.8 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Mur_ligase_M PF08245.12 EGD97253.1 - 6.5e-07 29.5 0.0 5.3e-05 23.3 0.0 2.9 1 1 0 1 1 1 1 Mur ligase middle domain FAM35_C PF15793.5 EGD97253.1 - 0.18 11.2 0.0 0.39 10.1 0.0 1.5 1 0 0 1 1 1 0 Protein family FAM35, C-terminal Syja_N PF02383.18 EGD97254.1 - 8.9e-89 298.0 0.0 1.1e-88 297.6 0.0 1.1 1 0 0 1 1 1 1 SacI homology domain FUN14 PF04930.15 EGD97254.1 - 0.026 14.9 0.1 1.2 9.5 0.0 3.0 3 0 0 3 3 3 0 FUN14 family zf-CCCH PF00642.24 EGD97255.1 - 2.5e-17 62.3 25.0 2.1e-06 27.5 0.7 5.3 5 0 0 5 5 5 5 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 EGD97255.1 - 2.1e-09 37.1 27.0 0.00056 19.9 2.5 5.2 5 0 0 5 5 5 4 Zinc finger domain Torus PF16131.5 EGD97255.1 - 5e-06 27.2 25.4 0.41 11.3 0.2 5.4 1 1 3 5 5 5 5 Torus domain zf-C3H1 PF10650.9 EGD97255.1 - 0.33 10.7 7.7 1.1 9.0 0.4 3.5 3 0 0 3 3 3 0 Putative zinc-finger domain TRP_N PF14558.6 EGD97255.1 - 0.4 11.1 3.6 15 5.9 0.1 3.0 2 1 1 3 3 3 0 ML-like domain zf-CCCH_4 PF18044.1 EGD97255.1 - 4.7 7.1 28.4 0.96 9.3 0.1 5.1 5 0 0 5 5 5 0 CCCH-type zinc finger Glyco_hydro_18 PF00704.28 EGD97256.1 - 3.8e-71 240.4 0.0 4.3e-71 240.2 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Glyco_hydro_75 PF07335.11 EGD97257.1 - 6.2e-34 117.6 0.0 7.3e-34 117.4 0.0 1.1 1 0 0 1 1 1 1 Fungal chitosanase of glycosyl hydrolase group 75 DUF3712 PF12505.8 EGD97258.1 - 7.4e-34 116.7 4.0 1.1e-33 116.1 2.5 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF3712) ASFV_J13L PF05568.11 EGD97258.1 - 0.097 12.4 0.1 0.15 11.8 0.1 1.2 1 0 0 1 1 1 0 African swine fever virus J13L protein DUF4307 PF14155.6 EGD97258.1 - 0.11 12.3 0.4 0.23 11.3 0.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4307) Sel1 PF08238.12 EGD97259.1 - 6.8e-11 42.5 12.7 0.00031 21.3 2.6 4.1 4 0 0 4 4 4 3 Sel1 repeat Glyco_hydro_18 PF00704.28 EGD97260.1 - 1.8e-25 90.3 1.6 3.1e-24 86.3 1.6 2.0 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 DUF4849 PF16141.5 EGD97260.1 - 0.0013 18.0 0.3 0.0057 16.0 0.3 2.1 1 1 0 1 1 1 1 Putative glycoside hydrolase Family 18, chitinase_18 GDI PF00996.18 EGD97260.1 - 0.012 14.2 0.0 0.016 13.7 0.0 1.1 1 0 0 1 1 1 0 GDP dissociation inhibitor Syndecan PF01034.20 EGD97261.1 - 0.091 12.7 0.9 0.22 11.4 0.9 1.6 1 0 0 1 1 1 0 Syndecan domain Myc_target_1 PF15179.6 EGD97261.1 - 0.28 11.0 7.8 0.3 11.0 0.0 2.1 2 0 0 2 2 2 0 Myc target protein 1 TFIIA PF03153.13 EGD97261.1 - 2 8.4 17.9 2.4 8.1 17.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit F-box PF00646.33 EGD97262.1 - 0.011 15.6 1.9 0.015 15.2 0.1 2.2 2 0 0 2 2 2 0 F-box domain F-box_4 PF15966.5 EGD97262.1 - 0.012 15.5 0.0 0.028 14.3 0.0 1.6 1 0 0 1 1 1 0 F-box F-box-like PF12937.7 EGD97262.1 - 0.032 14.1 1.6 0.11 12.4 0.2 2.6 2 0 0 2 2 2 0 F-box-like YrzO PF14142.6 EGD97262.1 - 2.5 8.1 4.1 5.5 7.0 4.1 1.5 1 0 0 1 1 1 0 YrzO-like protein DUF1776 PF08643.10 EGD97264.1 - 5.8e-88 295.1 0.0 7e-88 294.8 0.0 1.1 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) WLM PF08325.10 EGD97265.1 - 2.1e-67 226.9 0.1 3.3e-67 226.3 0.1 1.3 1 0 0 1 1 1 1 WLM domain zf-RanBP PF00641.18 EGD97265.1 - 0.00016 20.9 1.4 0.00016 20.9 1.4 3.1 2 1 0 2 2 2 2 Zn-finger in Ran binding protein and others DUF45 PF01863.17 EGD97265.1 - 0.0068 16.5 2.0 0.014 15.4 2.0 1.5 1 0 0 1 1 1 1 Protein of unknown function DUF45 SprT-like PF10263.9 EGD97265.1 - 0.018 14.9 0.1 0.033 14.0 0.1 1.4 1 0 0 1 1 1 0 SprT-like family Peptidase_M54 PF07998.11 EGD97265.1 - 0.018 15.0 0.0 0.028 14.4 0.0 1.2 1 0 0 1 1 1 0 Peptidase family M54 DZR PF12773.7 EGD97265.1 - 0.57 10.3 7.0 3.5 7.7 2.3 2.4 2 0 0 2 2 2 0 Double zinc ribbon C1_2 PF03107.16 EGD97265.1 - 0.9 9.9 4.8 15 6.0 0.8 2.7 2 0 0 2 2 2 0 C1 domain SVIP PF15811.5 EGD97265.1 - 3.4 8.2 6.1 21 5.7 0.7 2.8 2 0 0 2 2 2 0 Small VCP/p97-interacting protein Pkinase PF00069.25 EGD97266.1 - 5.9e-21 75.0 0.0 3.4e-20 72.5 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD97266.1 - 1.6e-06 27.6 0.0 0.0015 17.9 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase_fungal PF17667.1 EGD97266.1 - 0.073 11.8 0.0 0.11 11.2 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase Regulator_TrmB PF11495.8 EGD97267.1 - 0.099 11.8 0.2 0.12 11.5 0.2 1.2 1 0 0 1 1 1 0 Archaeal transcriptional regulator TrmB Trp_DMAT PF11991.8 EGD97268.1 - 3.3e-103 345.9 0.0 3.8e-103 345.7 0.0 1.0 1 0 0 1 1 1 1 Tryptophan dimethylallyltransferase FAD_binding_3 PF01494.19 EGD97269.1 - 7.8e-13 48.4 1.2 1.4e-11 44.3 1.2 2.5 1 1 0 1 1 1 1 FAD binding domain FAD_binding_2 PF00890.24 EGD97269.1 - 1.1e-06 28.0 1.1 2.6e-06 26.8 1.1 1.6 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 EGD97269.1 - 1.2e-06 28.0 1.1 0.0014 17.9 0.2 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EGD97269.1 - 4.4e-05 22.4 0.8 0.0018 17.1 0.6 2.1 2 0 0 2 2 2 1 HI0933-like protein DAO PF01266.24 EGD97269.1 - 0.00068 19.3 3.0 0.31 10.6 1.3 2.2 1 1 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 EGD97269.1 - 0.0024 17.2 0.1 1 8.5 0.3 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 EGD97269.1 - 0.0036 16.6 0.4 0.0065 15.8 0.4 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain GIDA PF01134.22 EGD97269.1 - 0.0064 15.6 1.4 0.0066 15.6 0.5 1.4 2 0 0 2 2 2 1 Glucose inhibited division protein A FAD_oxidored PF12831.7 EGD97269.1 - 0.0069 15.8 0.4 0.01 15.2 0.4 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EGD97269.1 - 0.019 15.2 0.4 0.07 13.4 0.2 2.1 3 0 0 3 3 3 0 NAD(P)-binding Rossmann-like domain AMP-binding PF00501.28 EGD97270.1 - 3.4e-63 213.7 0.0 3.7e-31 108.1 0.0 2.3 1 1 1 2 2 2 2 AMP-binding enzyme Condensation PF00668.20 EGD97270.1 - 2.7e-52 178.0 0.0 2.3e-31 109.0 0.0 3.6 2 1 0 2 2 2 2 Condensation domain PP-binding PF00550.25 EGD97270.1 - 1e-26 93.0 0.2 2.9e-12 46.7 0.0 2.9 2 0 0 2 2 2 2 Phosphopantetheine attachment site AMP-binding_C PF13193.6 EGD97270.1 - 0.0024 18.8 0.0 0.0086 17.0 0.0 2.0 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain GRIP PF01465.20 EGD97270.1 - 0.077 12.9 0.0 0.2 11.6 0.0 1.7 1 0 0 1 1 1 0 GRIP domain DFRP_C PF16543.5 EGD97270.1 - 0.18 12.3 0.2 0.37 11.3 0.2 1.5 1 0 0 1 1 1 0 DRG Family Regulatory Proteins, Tma46 Ribonuclease PF00545.20 EGD97271.1 - 1.8e-07 31.8 0.0 2.8e-07 31.2 0.0 1.3 1 0 0 1 1 1 1 ribonuclease WD40 PF00400.32 EGD97272.1 - 1.5e-44 149.1 35.5 2.6e-05 24.9 0.2 12.3 11 1 0 11 11 11 9 WD domain, G-beta repeat Utp12 PF04003.12 EGD97272.1 - 9.4e-22 77.3 0.0 2.4e-21 76.0 0.0 1.7 1 0 0 1 1 1 1 Dip2/Utp12 Family ANAPC4_WD40 PF12894.7 EGD97272.1 - 1.1e-19 70.5 7.2 0.0025 18.1 0.0 9.9 5 2 4 10 10 10 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EGD97272.1 - 9.9e-09 34.6 1.7 0.25 10.3 0.5 5.0 3 1 0 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 EGD97272.1 - 4e-06 26.4 0.0 0.12 11.7 0.0 3.8 4 0 0 4 4 4 2 WD40-like domain Nup160 PF11715.8 EGD97272.1 - 1.4e-05 24.0 2.5 0.52 8.9 0.0 5.5 6 0 0 6 6 6 2 Nucleoporin Nup120/160 Frtz PF11768.8 EGD97272.1 - 0.00074 18.0 0.0 0.073 11.4 0.0 2.4 2 0 0 2 2 2 2 WD repeat-containing and planar cell polarity effector protein Fritz P34-Arc PF04045.14 EGD97273.1 - 3.6e-104 347.7 0.0 4.3e-104 347.5 0.0 1.0 1 0 0 1 1 1 1 Arp2/3 complex, 34 kD subunit p34-Arc ARPC4 PF05856.12 EGD97273.1 - 0.065 12.8 0.0 0.31 10.6 0.0 1.9 2 0 0 2 2 2 0 ARP2/3 complex 20 kDa subunit (ARPC4) DUF2158 PF09926.9 EGD97273.1 - 0.15 11.8 0.0 0.28 11.0 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized small protein (DUF2158) DUF4294 PF14127.6 EGD97274.1 - 0.0043 17.0 0.0 0.0073 16.2 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4294) PP2C PF00481.21 EGD97275.1 - 9.4e-05 22.2 0.0 0.36 10.4 0.1 2.1 2 0 0 2 2 2 2 Protein phosphatase 2C PP2C_2 PF13672.6 EGD97275.1 - 0.0025 17.5 0.0 0.0035 17.0 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 EGD97275.1 - 0.0026 17.7 0.1 0.0098 15.8 0.1 1.9 1 1 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) Fcf1 PF04900.12 EGD97276.1 - 2.5e-19 69.5 0.3 4.6e-10 39.8 0.0 2.7 2 1 0 2 2 2 2 Fcf1 Cmc1 PF08583.10 EGD97277.1 - 1.2e-18 66.8 7.0 1.5e-18 66.6 7.0 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like HECA PF15353.6 EGD97277.1 - 0.072 13.3 1.7 0.092 13.0 1.7 1.2 1 0 0 1 1 1 0 Headcase protein family homologue WD40 PF00400.32 EGD97278.1 - 6e-15 55.4 13.8 0.00083 20.1 0.3 6.1 6 0 0 6 6 6 4 WD domain, G-beta repeat Nup160 PF11715.8 EGD97278.1 - 0.00046 19.0 4.2 0.017 13.8 0.7 2.9 1 1 1 3 3 3 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 EGD97278.1 - 0.0042 17.4 2.2 0.51 10.7 0.3 4.2 3 1 3 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 EGD97278.1 - 0.014 14.2 0.1 0.98 8.1 0.1 2.9 2 1 1 3 3 3 0 Nup133 N terminal like TENA_THI-4 PF03070.16 EGD97281.1 - 0.029 14.2 0.0 0.037 13.8 0.0 1.0 1 0 0 1 1 1 0 TENA/THI-4/PQQC family RRN3 PF05327.11 EGD97283.1 - 1.8e-168 561.6 0.0 1.8e-168 561.6 0.0 1.9 2 0 0 2 2 2 1 RNA polymerase I specific transcription initiation factor RRN3 Abhydrolase_3 PF07859.13 EGD97284.1 - 1.7e-40 139.2 0.2 1.8e-30 106.4 0.2 2.1 1 1 0 2 2 2 2 alpha/beta hydrolase fold COesterase PF00135.28 EGD97284.1 - 3.1e-10 39.6 0.0 6.6e-10 38.5 0.0 1.4 1 1 0 1 1 1 1 Carboxylesterase family DUF2974 PF11187.8 EGD97284.1 - 0.03 13.9 0.0 0.055 13.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) Esterase PF00756.20 EGD97284.1 - 0.036 13.7 0.1 0.079 12.6 0.1 1.5 1 1 0 1 1 1 0 Putative esterase Chlorophyllase2 PF12740.7 EGD97284.1 - 0.18 10.7 0.0 0.38 9.6 0.0 1.5 1 1 0 1 1 1 0 Chlorophyllase enzyme tRNA-synt_2 PF00152.20 EGD97285.1 - 6.7e-70 235.6 0.0 9.7e-70 235.1 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) DUF2156 PF09924.9 EGD97285.1 - 3.9e-17 62.2 0.0 5.8e-17 61.6 0.0 1.3 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2156) tRNA_anti-codon PF01336.25 EGD97285.1 - 0.00014 21.8 0.0 0.00029 20.8 0.0 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 EGD97285.1 - 0.00086 18.9 0.0 0.99 8.8 0.0 2.4 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) Ank_2 PF12796.7 EGD97286.1 - 5e-29 100.7 0.1 1.7e-08 35.0 0.0 5.3 2 2 2 5 5 5 4 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EGD97286.1 - 2.1e-17 61.4 0.3 0.033 14.7 0.0 8.5 9 0 0 9 9 9 3 Ankyrin repeat Ank_4 PF13637.6 EGD97286.1 - 7e-16 58.4 2.1 0.0026 18.3 0.0 7.0 3 3 4 7 7 7 6 Ankyrin repeats (many copies) Ank PF00023.30 EGD97286.1 - 1.5e-12 47.3 1.7 0.26 11.8 0.0 7.4 7 1 0 7 7 7 4 Ankyrin repeat Ank_5 PF13857.6 EGD97286.1 - 8.6e-09 35.5 1.2 0.018 15.4 0.0 6.2 6 3 3 9 9 9 2 Ankyrin repeats (many copies) DUF3447 PF11929.8 EGD97286.1 - 0.043 13.8 0.0 13 5.8 0.0 4.0 4 2 1 5 5 5 0 Domain of unknown function (DUF3447) VWA_3_C PF18571.1 EGD97286.1 - 0.15 12.0 0.7 21 5.1 0.0 3.2 3 0 0 3 3 3 0 von Willebrand factor type A C-terminal domain HLH PF00010.26 EGD97288.1 - 2.8e-13 49.6 0.3 2.8e-13 49.6 0.3 1.8 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain Septin PF00735.18 EGD97289.1 - 3.9e-10 39.5 0.1 5.3e-09 35.7 0.1 2.2 1 1 0 1 1 1 1 Septin MCM PF00493.23 EGD97289.1 - 0.012 14.7 0.0 0.023 13.8 0.0 1.3 1 0 0 1 1 1 0 MCM P-loop domain Zeta_toxin PF06414.12 EGD97289.1 - 0.027 13.7 0.0 0.077 12.3 0.0 1.7 1 0 0 1 1 1 0 Zeta toxin AAA_16 PF13191.6 EGD97289.1 - 0.048 14.0 0.0 0.12 12.7 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain Viral_helicase1 PF01443.18 EGD97289.1 - 0.067 12.9 0.0 0.13 12.0 0.0 1.5 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_24 PF13479.6 EGD97289.1 - 0.12 12.1 0.0 0.77 9.4 0.0 2.0 2 0 0 2 2 2 0 AAA domain Mg_chelatase PF01078.21 EGD97289.1 - 0.13 11.7 0.0 0.24 10.8 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI DUF815 PF05673.13 EGD97289.1 - 0.22 10.6 0.1 0.37 9.9 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF815) HSP90 PF00183.18 EGD97290.1 - 1.6e-220 733.4 30.9 2e-220 733.1 30.9 1.1 1 0 0 1 1 1 1 Hsp90 protein HATPase_c PF02518.26 EGD97290.1 - 6.5e-15 55.6 0.1 1.2e-14 54.8 0.1 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 EGD97290.1 - 1e-08 35.1 0.1 1e-08 35.1 0.1 2.0 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase ProQ PF04352.13 EGD97290.1 - 0.027 14.3 1.6 0.7 9.8 0.3 2.6 2 0 0 2 2 2 0 ProQ/FINO family LOH1CR12 PF10158.9 EGD97290.1 - 0.07 13.2 0.2 0.26 11.3 0.2 1.9 1 0 0 1 1 1 0 Tumour suppressor protein NTF2 PF02136.20 EGD97291.1 - 3.7e-23 82.4 0.2 6e-23 81.7 0.2 1.3 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain RRM_1 PF00076.22 EGD97291.1 - 1.9e-08 34.0 0.1 3.4e-08 33.2 0.1 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 EGD97291.1 - 0.023 14.7 0.0 0.055 13.5 0.0 1.7 1 0 0 1 1 1 0 RNA binding motif PPP4R2 PF09184.11 EGD97291.1 - 0.028 14.0 1.5 0.053 13.1 1.5 1.4 1 0 0 1 1 1 0 PPP4R2 TPR_17 PF13431.6 EGD97294.1 - 5.4e-05 23.3 0.9 0.64 10.5 0.0 3.9 4 0 0 4 4 4 2 Tetratricopeptide repeat Spt20 PF12090.8 EGD97294.1 - 0.0072 16.0 7.5 0.012 15.2 7.5 1.4 1 0 0 1 1 1 1 Spt20 family TPR_11 PF13414.6 EGD97294.1 - 0.012 15.3 3.1 0.19 11.5 0.0 3.8 4 0 0 4 4 4 0 TPR repeat TPR_1 PF00515.28 EGD97294.1 - 0.057 13.3 0.2 9 6.3 0.1 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF2722 PF10846.8 EGD97294.1 - 0.16 10.9 4.8 0.21 10.5 4.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) TPR_14 PF13428.6 EGD97294.1 - 0.24 12.3 3.6 23 6.1 0.0 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat UPF0560 PF10577.9 EGD97294.1 - 0.28 9.6 8.2 0.41 9.1 8.2 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Roughex PF06020.11 EGD97294.1 - 2.3 7.2 5.9 3.6 6.6 5.9 1.2 1 0 0 1 1 1 0 Drosophila roughex protein Nnf1 PF03980.14 EGD97295.1 - 1.3e-32 112.5 4.5 3e-32 111.3 4.5 1.6 1 0 0 1 1 1 1 Nnf1 FlgN PF05130.12 EGD97295.1 - 0.021 15.3 4.3 0.022 15.3 1.9 2.1 2 0 0 2 2 2 0 FlgN protein DUF16 PF01519.16 EGD97295.1 - 0.024 15.1 0.6 0.043 14.3 0.6 1.5 1 0 0 1 1 1 0 Protein of unknown function DUF16 DUF1887 PF09002.11 EGD97295.1 - 0.025 13.3 0.4 0.032 12.9 0.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1887) Cnn_1N PF07989.11 EGD97295.1 - 0.04 14.1 0.7 0.04 14.1 0.7 2.0 2 0 0 2 2 2 0 Centrosomin N-terminal motif 1 Mod_r PF07200.13 EGD97295.1 - 0.044 13.9 6.5 0.034 14.2 4.4 1.8 2 0 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein DUF948 PF06103.11 EGD97295.1 - 0.071 13.4 0.6 0.22 11.8 0.5 1.8 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Nup54 PF13874.6 EGD97295.1 - 0.089 12.9 6.1 0.078 13.1 4.0 1.9 2 0 0 2 2 2 0 Nucleoporin complex subunit 54 bZIP_1 PF00170.21 EGD97295.1 - 0.1 12.7 7.5 0.19 11.8 3.3 2.4 2 0 0 2 2 2 0 bZIP transcription factor MCM_N PF14551.6 EGD97295.1 - 0.11 13.1 0.8 0.18 12.4 0.7 1.6 1 1 1 2 2 2 0 MCM N-terminal domain DUF4515 PF14988.6 EGD97295.1 - 0.13 12.1 6.1 0.13 12.0 4.8 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4515) NYD-SP28 PF14772.6 EGD97295.1 - 0.57 10.3 7.3 0.18 11.8 4.0 1.9 2 0 0 2 2 2 0 Sperm tail TMPIT PF07851.13 EGD97295.1 - 0.65 9.2 2.2 0.86 8.8 2.2 1.2 1 0 0 1 1 1 0 TMPIT-like protein DUF1664 PF07889.12 EGD97295.1 - 0.68 10.0 3.7 1.2 9.2 3.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Uso1_p115_C PF04871.13 EGD97295.1 - 0.82 10.0 8.0 2.1 8.7 6.8 2.1 2 0 0 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region FlaC_arch PF05377.11 EGD97295.1 - 5.5 7.5 7.3 2.8 8.4 2.4 2.5 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) Pkinase PF00069.25 EGD97296.1 - 1.9e-75 253.6 0.0 3.3e-75 252.9 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD97296.1 - 4e-37 127.9 0.0 7.1e-37 127.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EGD97296.1 - 0.00033 19.7 3.9 0.00059 18.9 0.1 2.6 2 1 0 2 2 2 1 Haspin like kinase domain Kinase-like PF14531.6 EGD97296.1 - 0.036 13.4 0.1 0.036 13.4 0.1 2.5 2 2 2 4 4 4 0 Kinase-like APH PF01636.23 EGD97296.1 - 0.053 13.4 0.1 0.053 13.4 0.1 2.7 3 0 0 3 3 3 0 Phosphotransferase enzyme family SelP_N PF04592.14 EGD97296.1 - 0.38 10.1 11.1 0.62 9.4 11.1 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region TFIIA PF03153.13 EGD97296.1 - 7.7 6.4 17.0 1.9 8.4 14.0 1.5 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit SIR2 PF02146.17 EGD97297.1 - 6.9e-31 107.5 0.0 1.1e-30 106.9 0.0 1.3 1 0 0 1 1 1 1 Sir2 family AATase PF07247.12 EGD97298.1 - 3.1e-18 65.6 0.0 2.7e-17 62.5 0.0 2.3 1 1 0 1 1 1 1 Alcohol acetyltransferase MRP-L27 PF09809.9 EGD97298.1 - 0.035 13.9 0.0 0.092 12.6 0.0 1.6 2 0 0 2 2 2 0 Mitochondrial ribosomal protein L27 Cation_efflux PF01545.21 EGD97299.1 - 5.6e-55 186.2 5.8 7.8e-55 185.7 5.8 1.2 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 EGD97299.1 - 0.00016 21.8 0.0 0.00038 20.5 0.0 1.6 1 0 0 1 1 1 1 Dimerisation domain of Zinc Transporter FGGY_C PF02782.16 EGD97300.1 - 2.5e-30 105.7 0.0 6.1e-30 104.4 0.0 1.6 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.21 EGD97300.1 - 4.2e-19 69.1 0.0 1.2e-11 44.6 0.0 2.3 2 0 0 2 2 2 2 FGGY family of carbohydrate kinases, N-terminal domain Xpo1 PF08389.12 EGD97301.1 - 9.4e-38 129.6 0.8 9.4e-38 129.6 0.8 2.7 3 0 0 3 3 3 1 Exportin 1-like protein HEAT PF02985.22 EGD97301.1 - 0.026 14.7 0.1 1.1e+02 3.4 0.0 5.5 6 0 0 6 6 6 0 HEAT repeat 14-3-3 PF00244.20 EGD97301.1 - 0.043 13.3 0.2 0.091 12.3 0.2 1.5 1 0 0 1 1 1 0 14-3-3 protein Esterase PF00756.20 EGD97302.1 - 2e-55 188.2 0.0 2.4e-55 187.9 0.0 1.0 1 0 0 1 1 1 1 Putative esterase Peptidase_S9 PF00326.21 EGD97302.1 - 1.2e-05 24.9 0.0 1.9e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Chlorophyllase2 PF12740.7 EGD97302.1 - 9.3e-05 21.5 0.0 0.00016 20.7 0.0 1.3 1 0 0 1 1 1 1 Chlorophyllase enzyme Hydrolase_4 PF12146.8 EGD97302.1 - 0.0012 18.2 0.0 0.0018 17.6 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Esterase_phd PF10503.9 EGD97302.1 - 0.0013 18.3 0.0 0.051 13.0 0.0 2.1 2 0 0 2 2 2 1 Esterase PHB depolymerase Lipase_3 PF01764.25 EGD97302.1 - 0.026 14.4 0.0 0.039 13.8 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 3) PGAP1 PF07819.13 EGD97302.1 - 0.033 13.9 0.0 0.039 13.7 0.0 1.2 1 0 0 1 1 1 0 PGAP1-like protein Abhydrolase_3 PF07859.13 EGD97302.1 - 0.034 14.0 0.0 0.37 10.6 0.0 2.4 2 1 1 3 3 3 0 alpha/beta hydrolase fold AXE1 PF05448.12 EGD97302.1 - 0.053 12.2 0.0 0.072 11.8 0.0 1.2 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) Abhydrolase_2 PF02230.16 EGD97302.1 - 0.055 13.3 0.0 0.087 12.6 0.0 1.3 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase DLH PF01738.18 EGD97302.1 - 0.084 12.4 0.0 0.27 10.8 0.0 1.8 2 1 0 2 2 2 0 Dienelactone hydrolase family Abhydrolase_6 PF12697.7 EGD97302.1 - 0.15 12.6 0.0 0.16 12.5 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family Peptidase_C50 PF03568.17 EGD97303.1 - 5.5e-150 499.9 0.0 1.2e-149 498.7 0.0 1.6 1 0 0 1 1 1 1 Peptidase family C50 CHAT PF12770.7 EGD97303.1 - 4.3e-05 23.1 0.0 0.00038 20.0 0.0 2.5 2 0 0 2 2 2 1 CHAT domain TPR_14 PF13428.6 EGD97303.1 - 3.6 8.7 5.5 28 5.9 0.2 4.6 6 0 0 6 6 6 0 Tetratricopeptide repeat RsbRD_N PF14361.6 EGD97303.1 - 6.6 7.5 6.1 1.2 9.9 0.6 2.9 3 0 0 3 3 3 0 RsbT co-antagonist protein rsbRD N-terminal domain DUF5321 PF17254.2 EGD97304.1 - 1.2e-49 167.9 0.1 1.4e-49 167.7 0.1 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5321) DUF2852 PF11014.8 EGD97304.1 - 0.012 15.7 0.1 0.017 15.2 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2852) Muted PF14942.6 EGD97304.1 - 0.021 15.2 1.8 0.029 14.7 1.8 1.2 1 0 0 1 1 1 0 Organelle biogenesis, Muted-like protein DUF1611 PF07755.11 EGD97304.1 - 0.041 13.2 0.0 0.059 12.6 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1611_C) P-loop domain CREPT PF16566.5 EGD97304.1 - 0.066 13.4 0.8 0.093 12.9 0.8 1.1 1 0 0 1 1 1 0 Cell-cycle alteration and expression-elevated protein in tumour YtpI PF14007.6 EGD97307.1 - 4.5 7.5 7.6 0.13 12.4 0.9 1.8 2 0 0 2 2 2 0 YtpI-like protein Fungal_trans PF04082.18 EGD97309.1 - 2.3e-20 72.8 0.3 4.1e-20 71.9 0.3 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain p450 PF00067.22 EGD97310.1 - 1.4e-69 235.0 0.0 1.8e-69 234.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Terpene_synth_C PF03936.16 EGD97312.1 - 2.6e-10 40.1 0.2 8.4e-10 38.4 0.2 1.8 1 1 0 1 1 1 1 Terpene synthase family, metal binding domain MFS_1 PF07690.16 EGD97313.1 - 5.9e-35 120.8 24.7 6.5e-28 97.7 4.4 2.0 2 0 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EGD97313.1 - 1.7e-08 33.8 3.3 1.7e-08 33.8 3.3 2.7 2 1 0 2 2 2 1 Sugar (and other) transporter MFS_1_like PF12832.7 EGD97313.1 - 0.0013 17.7 0.9 0.0013 17.7 0.9 2.8 1 1 0 2 2 2 1 MFS_1 like family TRI12 PF06609.13 EGD97313.1 - 0.01 14.3 0.7 0.01 14.3 0.7 2.0 2 0 0 2 2 2 0 Fungal trichothecene efflux pump (TRI12) TFR_dimer PF04253.15 EGD97314.1 - 9.3e-31 106.5 0.0 1.5e-30 105.8 0.0 1.4 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain Peptidase_M28 PF04389.17 EGD97314.1 - 1e-20 74.3 0.0 2.3e-20 73.1 0.0 1.6 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.22 EGD97314.1 - 1.1e-09 38.1 0.0 5.1e-09 36.0 0.0 2.0 1 1 0 1 1 1 1 PA domain Peptidase_M20 PF01546.28 EGD97314.1 - 0.041 13.6 0.1 0.25 11.0 0.1 2.0 1 1 0 1 1 1 0 Peptidase family M20/M25/M40 zf-C2H2_4 PF13894.6 EGD97315.1 - 0.00032 21.3 2.0 0.0075 17.0 0.1 3.4 4 0 0 4 4 4 2 C2H2-type zinc finger zf-C2H2 PF00096.26 EGD97315.1 - 0.00069 19.9 5.1 0.012 16.1 0.1 3.1 3 0 0 3 3 3 2 Zinc finger, C2H2 type Ima1_N PF09779.9 EGD97315.1 - 0.069 14.0 0.4 0.21 12.4 0.4 1.9 1 1 0 1 1 1 0 Ima1 N-terminal domain IHABP4_N PF16174.5 EGD97315.1 - 4 8.0 13.0 0.8 10.3 2.9 2.4 2 0 0 2 2 2 0 Intracellular hyaluronan-binding protein 4 N-terminal TFIIA PF03153.13 EGD97319.1 - 3.7e-86 290.7 22.5 5.1e-86 290.3 22.5 1.4 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit DUF2563 PF10817.8 EGD97319.1 - 0.05 14.2 0.7 0.1 13.2 0.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2563) BOP1NT PF08145.12 EGD97319.1 - 1.8 8.4 11.6 0.24 11.3 4.9 2.2 2 0 0 2 2 2 0 BOP1NT (NUC169) domain DUF1387 PF07139.11 EGD97319.1 - 2.5 7.8 8.5 3.3 7.3 4.8 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1387) zf-C2H2_aberr PF17017.5 EGD97320.1 - 0.0001 22.5 1.0 0.041 14.0 0.0 2.3 2 0 0 2 2 2 2 Aberrant zinc-finger zf-C2H2_4 PF13894.6 EGD97320.1 - 0.00013 22.5 11.3 0.03 15.1 0.6 4.1 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2 PF00096.26 EGD97320.1 - 0.0072 16.7 19.6 0.05 14.1 0.8 4.4 4 0 0 4 4 4 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EGD97320.1 - 0.026 14.9 0.5 0.026 14.9 0.5 3.5 4 0 0 4 4 4 0 Zinc-finger double domain DUF4719 PF15843.5 EGD97320.1 - 0.11 12.6 0.0 0.11 12.6 0.0 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4719) Bap31 PF05529.12 EGD97321.1 - 2.9e-48 163.2 7.1 3.7e-48 162.8 7.1 1.1 1 0 0 1 1 1 1 Bap31/Bap29 transmembrane region Bap31_Bap29_C PF18035.1 EGD97321.1 - 7.2e-16 57.9 3.8 1.1e-15 57.3 3.8 1.3 1 0 0 1 1 1 1 Bap31/Bap29 cytoplasmic coiled-coil domain Atg14 PF10186.9 EGD97321.1 - 0.03 13.4 1.3 0.039 13.1 1.3 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 TMF_TATA_bd PF12325.8 EGD97321.1 - 0.032 14.4 0.5 0.057 13.6 0.4 1.5 1 1 0 1 1 1 0 TATA element modulatory factor 1 TATA binding DivIC PF04977.15 EGD97321.1 - 0.04 13.7 2.6 0.078 12.8 0.3 2.5 2 1 0 2 2 2 0 Septum formation initiator Cep57_MT_bd PF06657.13 EGD97321.1 - 0.075 13.5 0.1 0.14 12.6 0.1 1.4 1 0 0 1 1 1 0 Centrosome microtubule-binding domain of Cep57 DUF4349 PF14257.6 EGD97321.1 - 0.12 11.8 0.2 0.12 11.8 0.2 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4349) MMM1 PF10296.9 EGD97322.1 - 2e-07 30.4 0.0 4.6e-07 29.2 0.0 1.5 2 0 0 2 2 2 1 Maintenance of mitochondrial morphology protein 1 Pkinase PF00069.25 EGD97326.1 - 1.4e-63 214.7 0.0 2.3e-63 214.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD97326.1 - 9.9e-35 120.1 0.0 2.6e-29 102.3 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 EGD97326.1 - 2.5e-06 27.0 0.0 0.00059 19.2 0.0 2.2 1 1 0 1 1 1 1 Kinase-like APH PF01636.23 EGD97326.1 - 0.00039 20.4 0.4 0.0015 18.5 0.0 2.1 2 0 0 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.22 EGD97326.1 - 0.0031 17.1 0.2 0.0079 15.8 0.0 1.7 2 0 0 2 2 2 1 RIO1 family Haspin_kinase PF12330.8 EGD97326.1 - 0.016 14.2 0.2 0.026 13.5 0.2 1.3 1 0 0 1 1 1 0 Haspin like kinase domain Kdo PF06293.14 EGD97326.1 - 0.033 13.5 0.0 0.06 12.7 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family TSA PF03249.13 EGD97326.1 - 2.7 6.7 5.8 0.76 8.5 1.0 2.1 2 0 0 2 2 2 0 Type specific antigen Senescence PF06911.12 EGD97327.1 - 1.8e-54 184.8 2.1 2.9e-54 184.2 2.1 1.3 1 0 0 1 1 1 1 Senescence-associated protein Stanniocalcin PF03298.13 EGD97328.1 - 4.7e-05 22.8 0.1 5.3e-05 22.6 0.1 1.1 1 0 0 1 1 1 1 Stanniocalcin family Acyl-CoA_dh_1 PF00441.24 EGD97329.1 - 6.1e-38 130.4 6.2 9.9e-38 129.7 6.2 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 EGD97329.1 - 5e-30 104.5 0.8 1.3e-29 103.1 0.1 2.0 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 EGD97329.1 - 3.5e-24 84.8 0.0 1.3e-23 83.0 0.0 2.0 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 EGD97329.1 - 2.8e-14 53.5 2.4 5.3e-14 52.6 2.4 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain AgrD PF05931.11 EGD97329.1 - 0.0064 16.5 0.0 0.022 14.8 0.0 1.8 1 0 0 1 1 1 1 Staphylococcal AgrD protein HpaB_N PF11794.8 EGD97329.1 - 0.019 14.6 0.0 0.051 13.2 0.0 1.7 1 1 0 1 1 1 0 4-hydroxyphenylacetate 3-hydroxylase N terminal MFS_1 PF07690.16 EGD97330.1 - 6.3e-25 87.8 38.6 4.2e-20 72.0 9.4 2.1 1 1 0 2 2 2 2 Major Facilitator Superfamily MFS_3 PF05977.13 EGD97330.1 - 1e-06 27.4 1.0 1.6e-06 26.8 1.0 1.2 1 0 0 1 1 1 1 Transmembrane secretion effector MFS_1_like PF12832.7 EGD97330.1 - 0.00055 18.9 1.9 0.00055 18.9 1.9 3.2 3 1 1 4 4 4 2 MFS_1 like family GWT1 PF06423.12 EGD97332.1 - 1.1e-38 132.7 5.4 2e-38 131.8 2.4 2.5 2 0 0 2 2 2 1 GWT1 DUF4818 PF16089.5 EGD97332.1 - 0.016 15.7 1.9 0.53 10.8 0.0 3.5 3 1 0 3 3 3 0 Domain of unknown function (DUF4818) Amidase PF01425.21 EGD97333.1 - 5.1e-78 263.0 0.1 1.8e-77 261.3 0.1 1.7 1 1 0 1 1 1 1 Amidase DnaJ PF00226.31 EGD97334.1 - 1.6e-10 41.0 0.2 3.4e-10 39.9 0.2 1.5 1 0 0 1 1 1 1 DnaJ domain Sec63 PF02889.16 EGD97334.1 - 7.7e-06 25.3 0.0 0.00013 21.2 0.0 2.2 1 1 0 1 1 1 1 Sec63 Brl domain Peptidase_M24 PF00557.24 EGD97336.1 - 1.9e-52 178.0 0.0 2.5e-52 177.6 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.16 EGD97336.1 - 2.6e-22 78.8 0.0 4.8e-22 78.0 0.0 1.4 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain NAD_binding_8 PF13450.6 EGD97336.1 - 0.033 14.4 0.0 6.6 7.1 0.0 2.6 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain SPRY PF00622.28 EGD97339.1 - 1.2e-19 70.6 0.0 1.2e-19 70.6 0.0 1.9 2 0 0 2 2 2 1 SPRY domain TFIIA PF03153.13 EGD97339.1 - 0.00032 20.8 11.3 0.00032 20.8 11.3 2.2 2 0 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit TMEM51 PF15345.6 EGD97339.1 - 0.089 12.6 5.5 7.1 6.4 1.6 3.4 3 0 0 3 3 3 0 Transmembrane protein 51 DUF3611 PF12263.8 EGD97339.1 - 0.15 11.9 0.0 0.3 11.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3611) DUF4199 PF13858.6 EGD97339.1 - 0.21 12.0 1.0 1.6 9.1 0.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4199) Spt20 PF12090.8 EGD97339.1 - 2 8.0 23.2 0.045 13.4 13.2 2.2 2 0 0 2 2 2 0 Spt20 family Presenilin PF01080.17 EGD97339.1 - 4.8 5.8 7.9 4.8 5.8 4.7 2.0 2 0 0 2 2 2 0 Presenilin PDEase_II PF02112.15 EGD97340.1 - 1.9e-55 188.3 0.0 1.8e-26 93.0 0.0 3.0 3 0 0 3 3 3 3 cAMP phosphodiesterases class-II Lactamase_B_2 PF12706.7 EGD97340.1 - 0.00098 18.7 0.0 0.0018 17.8 0.0 1.5 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 EGD97340.1 - 0.0024 17.9 0.1 0.0053 16.8 0.1 1.5 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Zn_clus PF00172.18 EGD97341.1 - 2.2e-10 40.5 10.4 2.2e-10 40.5 10.4 1.9 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EGD97341.1 - 1.2e-06 27.7 0.1 2.1e-06 27.0 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Dak1_2 PF13684.6 EGD97341.1 - 0.22 10.5 0.0 0.34 10.0 0.0 1.2 1 0 0 1 1 1 0 Dihydroxyacetone kinase family adh_short PF00106.25 EGD97342.1 - 1e-17 64.3 0.0 4e-16 59.0 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EGD97342.1 - 9.7e-10 38.4 0.0 6.3e-08 32.5 0.0 2.1 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EGD97342.1 - 3.7e-08 33.5 0.0 6.6e-08 32.7 0.0 1.4 1 0 0 1 1 1 1 KR domain Zn_clus PF00172.18 EGD97343.1 - 6.1e-09 35.9 11.8 1.7e-08 34.5 11.8 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF4568 PF15132.6 EGD97343.1 - 0.042 13.2 1.5 0.082 12.3 1.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4568) ALO PF04030.14 EGD97344.1 - 2.7e-91 306.0 0.1 4.3e-91 305.3 0.1 1.3 1 0 0 1 1 1 1 D-arabinono-1,4-lactone oxidase FAD_binding_4 PF01565.23 EGD97344.1 - 5e-31 107.3 0.2 8.2e-31 106.6 0.2 1.4 1 0 0 1 1 1 1 FAD binding domain DUF4045 PF13254.6 EGD97345.1 - 8.1e-92 309.0 45.9 8.1e-92 309.0 45.9 5.9 3 3 1 4 4 4 1 Domain of unknown function (DUF4045) Gelsolin PF00626.22 EGD97345.1 - 2.7e-05 24.0 0.0 0.03 14.2 0.0 2.9 2 0 0 2 2 2 2 Gelsolin repeat Arf PF00025.21 EGD97346.1 - 3.2e-60 202.6 0.3 3.5e-60 202.4 0.3 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EGD97346.1 - 5.8e-09 36.2 0.0 8.4e-09 35.7 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 EGD97346.1 - 1.4e-08 34.3 2.0 1.9e-06 27.3 0.8 2.6 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.22 EGD97346.1 - 5.4e-08 32.6 0.0 6.7e-08 32.3 0.0 1.1 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 EGD97346.1 - 4e-07 29.6 0.0 4.8e-07 29.4 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EGD97346.1 - 1.1e-05 25.5 0.0 1.6e-05 24.9 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EGD97346.1 - 0.00066 19.3 0.0 0.0057 16.2 0.0 2.1 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 EGD97346.1 - 0.0043 16.5 0.0 0.0058 16.1 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit HCV_NS1 PF01560.17 EGD97346.1 - 0.0058 15.4 0.0 0.0069 15.1 0.0 1.1 1 0 0 1 1 1 1 Hepatitis C virus non-structural protein E2/NS1 FeoB_N PF02421.18 EGD97346.1 - 0.14 11.7 0.1 0.42 10.1 0.1 1.8 1 1 0 1 1 1 0 Ferrous iron transport protein B DEAD PF00270.29 EGD97348.1 - 4.7e-46 156.8 0.0 8.3e-46 155.9 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EGD97348.1 - 1.3e-29 102.7 0.2 1.8e-27 95.8 0.1 2.8 3 0 0 3 3 3 1 Helicase conserved C-terminal domain UTP25 PF06862.12 EGD97348.1 - 0.0043 15.9 2.2 0.011 14.5 0.3 2.5 2 1 1 3 3 3 1 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 HMGL-like PF00682.19 EGD97349.1 - 7.8e-81 271.5 0.0 1.2e-80 270.9 0.0 1.3 1 0 0 1 1 1 1 HMGL-like LeuA_dimer PF08502.10 EGD97349.1 - 8.2e-21 74.3 0.0 1.5e-20 73.4 0.0 1.5 1 0 0 1 1 1 1 LeuA allosteric (dimerisation) domain AMP-binding PF00501.28 EGD97350.1 - 1.5e-64 218.2 0.1 1.4e-36 126.0 0.0 4.5 2 2 0 2 2 2 2 AMP-binding enzyme DMAP_binding PF06464.11 EGD97350.1 - 1e-08 36.0 0.0 2.8e-08 34.5 0.0 1.7 1 0 0 1 1 1 1 DMAP1-binding Domain GvpG PF05120.12 EGD97350.1 - 0.012 15.6 0.1 0.026 14.5 0.1 1.6 1 0 0 1 1 1 0 Gas vesicle protein G Carb_anhydrase PF00194.21 EGD97351.1 - 4.7e-33 114.8 0.0 9.9e-33 113.7 0.0 1.5 1 1 0 1 1 1 1 Eukaryotic-type carbonic anhydrase CA_like PF10563.9 EGD97351.1 - 1.3 8.9 3.8 0.8 9.6 0.6 2.1 3 1 1 4 4 4 0 Putative carbonic anhydrase RNR_inhib PF08591.10 EGD97352.1 - 1.6e-17 64.8 0.5 1.6e-17 64.8 0.5 1.6 2 0 0 2 2 2 1 Ribonucleotide reductase inhibitor SDA1 PF05285.12 EGD97353.1 - 1.5e-73 248.2 50.1 3.6e-73 247.0 43.3 2.9 2 1 0 2 2 2 2 SDA1 NUC130_3NT PF08158.12 EGD97353.1 - 3.4e-23 81.7 0.0 9.6e-23 80.3 0.0 1.8 1 0 0 1 1 1 1 NUC130/3NT domain Ribosomal_S7 PF00177.21 EGD97354.1 - 4.2e-37 127.1 1.7 5.2e-37 126.8 1.7 1.1 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e Methyltransf_23 PF13489.6 EGD97355.1 - 1.5e-15 57.5 0.0 2.4e-15 56.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EGD97355.1 - 6.6e-10 39.6 0.0 1.6e-09 38.3 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EGD97355.1 - 7.8e-06 26.5 0.0 1.7e-05 25.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EGD97355.1 - 1.4e-05 25.8 0.0 8.7e-05 23.2 0.0 2.3 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EGD97355.1 - 8e-05 22.5 0.0 0.00079 19.3 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_16 PF10294.9 EGD97355.1 - 0.016 14.9 0.0 0.025 14.3 0.0 1.2 1 0 0 1 1 1 0 Lysine methyltransferase MTS PF05175.14 EGD97355.1 - 0.052 13.1 0.0 0.098 12.2 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain PrmA PF06325.13 EGD97355.1 - 0.18 11.1 0.0 0.25 10.7 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) p450 PF00067.22 EGD97356.1 - 4.6e-65 220.2 0.0 5.5e-65 219.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Smim3 PF17307.2 EGD97356.1 - 0.14 11.7 0.5 0.25 10.9 0.5 1.3 1 0 0 1 1 1 0 Small integral membrane protein 3 Pkinase PF00069.25 EGD97357.1 - 6.8e-17 61.7 0.0 8.4e-10 38.5 0.0 2.6 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EGD97357.1 - 3.6e-06 26.4 0.2 0.03 13.6 0.0 3.1 3 0 0 3 3 3 2 Protein tyrosine kinase Kdo PF06293.14 EGD97357.1 - 0.1 11.9 0.1 0.25 10.7 0.0 1.6 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family 5_nucleotid_C PF02872.18 EGD97358.1 - 0.003 17.8 0.0 0.0088 16.3 0.0 1.8 1 0 0 1 1 1 1 5'-nucleotidase, C-terminal domain DmpG_comm PF07836.11 EGD97358.1 - 0.061 12.9 0.0 0.72 9.4 0.0 2.3 2 0 0 2 2 2 0 DmpG-like communication domain Pkinase PF00069.25 EGD97359.1 - 1.9e-22 79.9 0.0 4.8e-22 78.6 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD97359.1 - 0.00099 18.5 0.2 0.012 14.9 0.0 2.5 2 1 0 2 2 2 1 Protein tyrosine kinase APH PF01636.23 EGD97359.1 - 0.13 12.2 1.5 0.29 11.0 0.0 2.0 2 1 0 2 2 2 0 Phosphotransferase enzyme family 4HBT_3 PF13622.6 EGD97360.1 - 3.2e-78 263.4 0.6 3.9e-78 263.2 0.6 1.1 1 0 0 1 1 1 1 Thioesterase-like superfamily Acyl_CoA_thio PF02551.15 EGD97360.1 - 7.1e-25 87.4 0.0 1.6e-11 44.2 0.0 4.1 3 1 0 3 3 3 3 Acyl-CoA thioesterase DUF3445 PF11927.8 EGD97361.1 - 4.6e-63 212.9 0.0 6.1e-63 212.5 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3445) Lipase_GDSL_3 PF14606.6 EGD97361.1 - 0.088 12.9 0.0 0.29 11.3 0.0 1.7 2 0 0 2 2 2 0 GDSL-like Lipase/Acylhydrolase family DUF1917 PF08939.10 EGD97361.1 - 0.097 12.6 4.0 2.7 7.8 0.2 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF1917) HSP70 PF00012.20 EGD97364.1 - 2.5e-10 39.2 0.1 5.8e-09 34.7 0.1 2.0 2 0 0 2 2 2 2 Hsp70 protein MreB_Mbl PF06723.13 EGD97364.1 - 0.11 11.3 0.0 0.33 9.7 0.0 1.7 2 0 0 2 2 2 0 MreB/Mbl protein N2227 PF07942.12 EGD97365.1 - 2.1e-87 292.8 0.0 3.4e-87 292.1 0.0 1.3 1 1 0 1 1 1 1 N2227-like protein SelP_N PF04592.14 EGD97365.1 - 1.4 8.2 5.1 3.4 7.0 5.1 1.6 1 0 0 1 1 1 0 Selenoprotein P, N terminal region PAC4 PF16093.5 EGD97367.1 - 2e-25 88.8 0.5 2.8e-25 88.3 0.5 1.2 1 0 0 1 1 1 1 Proteasome assembly chaperone 4 Fungal_trans PF04082.18 EGD97368.1 - 8.9e-20 70.8 0.4 1.6e-19 70.0 0.4 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EGD97368.1 - 2.2e-05 24.5 12.8 2.2e-05 24.5 12.8 2.2 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DVL PF08137.12 EGD97368.1 - 6.4 6.8 6.4 20 5.2 6.4 1.9 1 0 0 1 1 1 0 DVL family Prefoldin_2 PF01920.20 EGD97369.1 - 4.9e-11 42.5 3.2 2.2e-08 34.0 0.1 2.1 2 0 0 2 2 2 2 Prefoldin subunit ORF6C PF10552.9 EGD97369.1 - 0.019 15.1 0.3 0.47 10.6 0.1 2.0 2 0 0 2 2 2 0 ORF6C domain PI3K_P85_iSH2 PF16454.5 EGD97369.1 - 0.03 13.9 0.2 0.03 13.9 0.2 2.0 2 0 0 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain GPS2_interact PF15784.5 EGD97369.1 - 0.04 14.3 0.6 0.04 14.3 0.6 1.9 1 1 0 1 1 1 0 G-protein pathway suppressor 2-interacting domain Osmo_CC PF08946.10 EGD97369.1 - 0.044 14.0 2.6 0.097 12.9 2.6 1.5 1 0 0 1 1 1 0 Osmosensory transporter coiled coil LPP PF04728.13 EGD97369.1 - 0.045 14.1 0.1 0.1 13.0 0.1 1.6 1 0 0 1 1 1 0 Lipoprotein leucine-zipper Syntaxin-6_N PF09177.11 EGD97369.1 - 0.054 14.0 1.0 0.13 12.9 1.0 1.6 1 1 0 1 1 1 0 Syntaxin 6, N-terminal DUF3338 PF11819.8 EGD97369.1 - 0.15 12.0 5.4 3.7 7.5 1.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3338) Spc24 PF08286.11 EGD97369.1 - 0.81 10.0 4.2 1.4 9.2 0.4 2.1 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 APG6_N PF17675.1 EGD97369.1 - 0.84 10.2 10.6 0.35 11.4 0.8 2.1 2 0 0 2 2 2 0 Apg6 coiled-coil region bZIP_1 PF00170.21 EGD97369.1 - 2 8.6 10.3 0.11 12.6 2.4 2.1 2 0 0 2 2 2 0 bZIP transcription factor ATG27 PF09451.10 EGD97370.1 - 9.8e-84 281.3 0.0 1.2e-83 281.1 0.0 1.0 1 0 0 1 1 1 1 Autophagy-related protein 27 CIMR PF00878.18 EGD97370.1 - 0.0003 20.9 0.2 0.11 12.5 0.1 2.3 2 0 0 2 2 2 2 Cation-independent mannose-6-phosphate receptor repeat DUF1242 PF06842.12 EGD97370.1 - 0.029 14.2 1.0 0.16 11.8 0.1 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF1242) SRP9-21 PF05486.12 EGD97370.1 - 0.1 13.0 1.1 0.2 12.1 1.1 1.4 1 0 0 1 1 1 0 Signal recognition particle 9 kDa protein (SRP9) Sulfotransfer_3 PF13469.6 EGD97371.1 - 0.0072 16.7 0.0 2.7 8.3 0.0 2.8 2 1 0 2 2 2 2 Sulfotransferase family KAAG1 PF15354.6 EGD97371.1 - 0.16 12.5 4.7 0.096 13.2 1.8 2.1 2 1 1 3 3 3 0 Kidney-associated antigen 1 Deltameth_res PF16020.5 EGD97372.1 - 0.016 15.1 0.1 0.038 13.9 0.1 1.6 1 0 0 1 1 1 0 Deltamethrin resistance AAA_2 PF07724.14 EGD97374.1 - 2.1e-44 151.6 0.0 1.3e-42 145.8 0.0 2.9 2 1 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_lid_9 PF17871.1 EGD97374.1 - 1.5e-32 111.6 7.5 2e-32 111.2 1.4 3.7 3 1 1 4 4 3 1 AAA lid domain AAA PF00004.29 EGD97374.1 - 2.7e-26 92.6 0.0 1.7e-14 54.4 0.0 2.9 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) ClpB_D2-small PF10431.9 EGD97374.1 - 1.6e-22 79.3 0.1 6.5e-22 77.4 0.1 2.2 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA_5 PF07728.14 EGD97374.1 - 1.8e-14 53.9 1.3 1e-07 32.0 0.0 4.0 3 1 0 3 3 3 2 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EGD97374.1 - 3.8e-14 53.4 0.7 1.2e-07 32.3 0.1 4.1 3 2 0 4 4 3 2 AAA ATPase domain AAA_22 PF13401.6 EGD97374.1 - 3.4e-12 46.8 1.5 0.00035 20.9 0.1 4.2 2 2 1 3 3 3 2 AAA domain Sigma54_activat PF00158.26 EGD97374.1 - 3e-09 36.8 0.0 4.5e-05 23.2 0.0 2.5 2 0 0 2 2 2 2 Sigma-54 interaction domain Clp_N PF02861.20 EGD97374.1 - 3.8e-07 30.1 4.3 0.0067 16.5 0.1 4.2 3 1 0 3 3 2 2 Clp amino terminal domain, pathogenicity island component TniB PF05621.11 EGD97374.1 - 3.8e-07 29.7 2.2 0.012 15.0 0.1 5.2 5 1 0 5 5 4 1 Bacterial TniB protein AAA_7 PF12775.7 EGD97374.1 - 5.9e-07 29.2 0.0 0.0093 15.5 0.0 2.9 2 1 0 2 2 2 2 P-loop containing dynein motor region IstB_IS21 PF01695.17 EGD97374.1 - 2.4e-06 27.4 0.0 0.094 12.4 0.0 2.7 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_18 PF13238.6 EGD97374.1 - 6e-06 26.8 0.1 0.12 12.9 0.0 3.4 3 0 0 3 3 2 2 AAA domain AAA_14 PF13173.6 EGD97374.1 - 6.9e-06 26.1 0.0 0.12 12.4 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_33 PF13671.6 EGD97374.1 - 1.1e-05 25.7 0.0 0.27 11.4 0.0 3.1 2 0 0 2 2 2 2 AAA domain Mg_chelatase PF01078.21 EGD97374.1 - 3.8e-05 23.2 0.0 0.15 11.4 0.0 3.4 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 EGD97374.1 - 3.9e-05 24.0 0.0 0.54 10.7 0.0 2.7 2 0 0 2 2 2 2 RNA helicase AAA_28 PF13521.6 EGD97374.1 - 4.6e-05 23.7 0.8 1.3 9.3 0.0 3.5 3 0 0 3 3 3 2 AAA domain RuvB_N PF05496.12 EGD97374.1 - 8.7e-05 22.3 1.9 2.2 8.0 1.6 4.4 3 1 0 3 3 3 1 Holliday junction DNA helicase RuvB P-loop domain ATPase_2 PF01637.18 EGD97374.1 - 9.3e-05 22.4 6.5 0.32 10.9 0.1 4.6 5 1 0 5 5 4 2 ATPase domain predominantly from Archaea TsaE PF02367.17 EGD97374.1 - 0.00013 21.9 0.0 0.15 12.1 0.0 2.5 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_3 PF07726.11 EGD97374.1 - 0.00014 21.7 0.0 1.3 8.9 0.0 3.3 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 EGD97374.1 - 0.00031 20.5 0.0 0.55 9.9 0.0 3.2 3 0 0 3 3 2 1 AAA domain ABC_tran PF00005.27 EGD97374.1 - 0.00043 20.8 0.2 1.2 9.7 0.0 3.3 3 0 0 3 3 2 1 ABC transporter AAA_23 PF13476.6 EGD97374.1 - 0.00057 20.4 9.6 0.22 12.0 0.0 4.8 5 0 0 5 5 5 1 AAA domain RsgA_GTPase PF03193.16 EGD97374.1 - 0.00058 19.8 0.0 0.82 9.6 0.0 2.9 2 0 0 2 2 2 1 RsgA GTPase AAA_24 PF13479.6 EGD97374.1 - 0.00067 19.4 0.0 0.6 9.8 0.0 2.6 2 0 0 2 2 2 1 AAA domain Torsin PF06309.11 EGD97374.1 - 0.0015 18.6 0.0 0.0058 16.7 0.0 1.9 2 0 0 2 2 1 1 Torsin NTPase_1 PF03266.15 EGD97374.1 - 0.0022 17.9 0.2 0.1 12.5 0.0 3.3 3 0 0 3 3 3 1 NTPase AAA_19 PF13245.6 EGD97374.1 - 0.0029 18.0 0.1 0.82 10.0 0.1 3.2 2 1 0 3 3 3 1 AAA domain AAA_29 PF13555.6 EGD97374.1 - 0.0061 16.3 0.0 6.9 6.5 0.0 2.8 2 0 0 2 2 2 0 P-loop containing region of AAA domain NACHT PF05729.12 EGD97374.1 - 0.0063 16.4 0.0 0.38 10.6 0.0 2.6 2 0 0 2 2 2 1 NACHT domain T2SSE PF00437.20 EGD97374.1 - 0.0065 15.6 0.0 0.066 12.3 0.0 2.4 2 0 0 2 2 2 1 Type II/IV secretion system protein Rad17 PF03215.15 EGD97374.1 - 0.0079 16.1 0.0 7.2 6.5 0.0 2.8 3 0 0 3 3 2 0 Rad17 P-loop domain AAA_25 PF13481.6 EGD97374.1 - 0.0083 15.7 0.1 1.1 8.8 0.0 2.8 2 0 0 2 2 2 1 AAA domain Roc PF08477.13 EGD97374.1 - 0.0084 16.3 0.0 2.7 8.2 0.0 2.7 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase SRP54 PF00448.22 EGD97374.1 - 0.0096 15.6 0.1 1.6 8.4 0.0 2.8 3 0 0 3 3 2 1 SRP54-type protein, GTPase domain Zeta_toxin PF06414.12 EGD97374.1 - 0.013 14.8 0.0 5.6 6.2 0.0 2.8 2 0 0 2 2 2 0 Zeta toxin ResIII PF04851.15 EGD97374.1 - 0.02 14.9 0.0 3 7.8 0.0 3.2 3 0 0 3 3 3 0 Type III restriction enzyme, res subunit MMR_HSR1 PF01926.23 EGD97374.1 - 0.043 13.9 0.8 2.5 8.2 0.2 3.6 3 1 0 3 3 2 0 50S ribosome-binding GTPase ATP_bind_1 PF03029.17 EGD97374.1 - 0.14 11.9 0.1 19 5.0 0.0 2.9 3 0 0 3 3 2 0 Conserved hypothetical ATP binding protein FRQ PF09421.10 EGD97374.1 - 0.28 9.1 3.7 0.53 8.2 3.7 1.3 1 0 0 1 1 1 0 Frequency clock protein SNF2_N PF00176.23 EGD97375.1 - 2.5e-64 217.2 0.0 3.7e-64 216.6 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EGD97375.1 - 4.9e-15 55.8 0.0 1.1e-14 54.8 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EGD97375.1 - 4.9e-10 39.7 0.0 1.5e-09 38.0 0.0 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 EGD97375.1 - 0.0077 15.4 0.0 0.017 14.3 0.0 1.5 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 SpoIIIAH PF12685.7 EGD97376.1 - 0.00036 20.4 1.1 0.00039 20.3 1.1 1.0 1 0 0 1 1 1 1 SpoIIIAH-like protein SARAF PF06682.12 EGD97376.1 - 0.028 14.1 0.0 0.032 13.9 0.0 1.1 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis TRAP_alpha PF03896.16 EGD97376.1 - 0.083 12.1 4.8 0.11 11.7 4.8 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Serinc PF03348.15 EGD97376.1 - 0.086 11.8 0.0 0.099 11.6 0.0 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) NOA36 PF06524.12 EGD97376.1 - 0.2 11.0 25.5 0.24 10.7 25.5 1.1 1 0 0 1 1 1 0 NOA36 protein Zip PF02535.22 EGD97376.1 - 0.24 10.6 0.2 0.26 10.4 0.2 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter ORC_WH_C PF18137.1 EGD97376.1 - 0.36 10.9 3.2 0.53 10.4 3.2 1.3 1 0 0 1 1 1 0 Origin recognition complex winged helix C-terminal RPN2_C PF18004.1 EGD97376.1 - 0.51 10.2 3.1 0.61 10.0 3.1 1.2 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain EBP PF05241.12 EGD97377.1 - 5.5e-59 198.6 10.8 6.5e-59 198.4 10.8 1.0 1 0 0 1 1 1 1 Emopamil binding protein DUF2347 PF09804.9 EGD97378.1 - 7.1e-102 340.8 0.0 1.3e-101 340.0 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2347) DUF4484 PF14831.6 EGD97378.1 - 1.4e-59 201.6 2.7 2.1e-59 201.1 2.7 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4484) Avl9 PF09794.9 EGD97378.1 - 4.2e-07 29.0 0.0 0.0014 17.5 0.0 2.2 2 0 0 2 2 2 2 Transport protein Avl9 SPA PF08616.10 EGD97378.1 - 0.021 14.7 0.0 0.04 13.9 0.0 1.4 1 0 0 1 1 1 0 Stabilization of polarity axis Homez PF11569.8 EGD97378.1 - 0.12 11.9 0.1 0.34 10.4 0.1 1.8 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez Spc7 PF08317.11 EGD97379.1 - 0.59 9.0 19.8 1.1 8.0 19.8 1.4 1 0 0 1 1 1 0 Spc7 kinetochore protein DinB_2 PF12867.7 EGD97379.1 - 0.59 10.6 3.9 4 8.0 0.1 2.8 2 1 0 2 2 2 0 DinB superfamily FapA PF03961.13 EGD97379.1 - 1.7 7.1 7.6 2.9 6.4 7.6 1.3 1 0 0 1 1 1 0 Flagellar Assembly Protein A Pet100 PF09803.9 EGD97379.1 - 7.9 7.1 5.6 2.7 8.6 0.7 2.7 1 1 1 2 2 2 0 Pet100 Tubulin_3 PF14881.6 EGD97380.1 - 3.4e-82 274.5 0.1 5.6e-82 273.8 0.1 1.3 1 0 0 1 1 1 1 Tubulin domain Misat_Tub_SegII PF10644.9 EGD97380.1 - 3.4e-23 82.2 0.0 9.5e-23 80.7 0.0 1.7 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin PF00091.25 EGD97380.1 - 0.0027 17.9 0.0 0.0055 16.9 0.0 1.5 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain HSP70 PF00012.20 EGD97383.1 - 3.7e-63 213.7 17.9 1.5e-62 211.6 2.8 2.8 3 1 0 3 3 3 2 Hsp70 protein DUF4296 PF14129.6 EGD97383.1 - 0.12 13.0 0.4 1 10.0 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4296) MFS_1 PF07690.16 EGD97384.1 - 9.7e-31 107.0 57.9 6.5e-29 101.0 56.5 2.9 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EGD97384.1 - 9.1e-08 31.4 13.3 9.1e-08 31.4 13.3 2.8 3 0 0 3 3 3 1 Sugar (and other) transporter SpoVS PF04232.12 EGD97384.1 - 5.6 6.8 9.5 4.7 7.0 1.8 2.7 2 1 0 2 2 2 0 Stage V sporulation protein S (SpoVS) FAM199X PF15814.5 EGD97385.1 - 0.11 11.5 2.5 0.19 10.7 2.5 1.3 1 0 0 1 1 1 0 Protein family FAM199X tRNA-synt_1c PF00749.21 EGD97386.1 - 8.6e-98 327.1 0.0 1.2e-97 326.6 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.18 EGD97386.1 - 2.2e-29 102.5 0.0 6.1e-29 101.1 0.0 1.7 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain ATPgrasp_N PF18130.1 EGD97389.1 - 3.6e-07 30.6 0.0 6.3e-07 29.9 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp N-terminal domain Dala_Dala_lig_C PF07478.13 EGD97389.1 - 0.00034 20.2 0.0 0.00039 20.0 0.0 1.2 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp_4 PF13535.6 EGD97389.1 - 0.0019 17.8 0.1 0.004 16.8 0.0 1.5 2 0 0 2 2 2 1 ATP-grasp domain GDPD PF03009.17 EGD97391.1 - 1e-23 84.4 0.0 2.5e-23 83.1 0.0 1.7 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family Ank_2 PF12796.7 EGD97391.1 - 2.5e-13 50.4 0.1 1.7e-05 25.3 0.0 3.5 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EGD97391.1 - 7.3e-10 39.2 0.4 6.6e-05 23.4 0.0 4.3 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EGD97391.1 - 5.9e-07 29.3 0.2 0.17 12.6 0.0 4.6 6 0 0 6 6 6 2 Ankyrin repeat Ank PF00023.30 EGD97391.1 - 7.1e-06 26.2 0.0 0.0029 18.0 0.0 3.3 2 0 0 2 2 2 1 Ankyrin repeat Ank_5 PF13857.6 EGD97391.1 - 5.8e-05 23.3 0.0 0.021 15.2 0.0 3.1 1 1 1 2 2 2 2 Ankyrin repeats (many copies) SPX PF03105.19 EGD97391.1 - 0.045 13.7 0.1 0.045 13.7 0.1 2.1 3 0 0 3 3 3 0 SPX domain Fe-S_assembly PF04384.13 EGD97392.1 - 0.023 15.3 0.0 0.033 14.8 0.0 1.2 1 0 0 1 1 1 0 Iron-sulphur cluster assembly DUF790 PF05626.11 EGD97393.1 - 0.068 11.9 0.2 0.11 11.2 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF790) Fungal_trans PF04082.18 EGD97394.1 - 1.8e-20 73.1 0.0 6.5e-19 68.0 0.0 2.5 2 0 0 2 2 2 2 Fungal specific transcription factor domain Zn_clus PF00172.18 EGD97394.1 - 2.1e-07 30.9 8.0 3.5e-07 30.2 8.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain But2 PF09792.9 EGD97396.1 - 0.0043 17.5 0.0 0.023 15.1 0.0 1.9 1 1 0 1 1 1 1 Ubiquitin 3 binding protein But2 C-terminal domain MFS_1 PF07690.16 EGD97397.1 - 6.1e-45 153.7 35.8 6.1e-45 153.7 35.8 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EGD97397.1 - 9.3e-14 51.1 5.9 2.1e-13 49.9 5.9 1.6 1 0 0 1 1 1 1 Sugar (and other) transporter TRI12 PF06609.13 EGD97397.1 - 5e-05 21.9 1.1 5e-05 21.9 1.1 2.0 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) MFS_4 PF06779.14 EGD97397.1 - 0.00056 19.3 5.0 0.00056 19.3 5.0 2.9 1 1 2 3 3 3 1 Uncharacterised MFS-type transporter YbfB Vps55 PF04133.14 EGD97397.1 - 0.017 15.1 0.6 0.017 15.1 0.6 2.9 3 0 0 3 3 3 0 Vacuolar protein sorting 55 DUF697 PF05128.12 EGD97397.1 - 2.3 7.9 4.6 8.4 6.1 0.0 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF697) Alpha-amylase PF00128.24 EGD97399.1 - 2.2e-25 89.9 0.2 5.6e-25 88.6 0.2 1.6 1 1 0 1 1 1 1 Alpha amylase, catalytic domain Glyco_hydro_70 PF02324.16 EGD97399.1 - 2.3e-05 22.8 1.5 0.0047 15.2 0.0 2.5 3 0 0 3 3 3 2 Glycosyl hydrolase family 70 DUF1939 PF09154.10 EGD97399.1 - 0.06 13.5 0.0 0.18 12.0 0.0 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF1939) DEAD PF00270.29 EGD97400.1 - 2.1e-24 86.2 0.3 8.8e-24 84.2 0.3 2.0 1 1 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EGD97400.1 - 7.4e-23 81.0 0.1 2.2e-22 79.5 0.0 1.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EGD97400.1 - 2.1e-05 24.6 0.0 5.9e-05 23.1 0.0 1.8 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit Ribonuc_L-PSP PF01042.21 EGD97401.1 - 6.9e-38 129.4 0.0 7.9e-38 129.2 0.0 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP GFA PF04828.14 EGD97403.1 - 0.055 13.8 0.0 0.11 12.9 0.0 1.6 1 1 0 1 1 1 0 Glutathione-dependent formaldehyde-activating enzyme HLH PF00010.26 EGD97404.1 - 3.8e-09 36.4 0.1 1e-08 35.0 0.0 1.7 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain Hamartin PF04388.12 EGD97404.1 - 0.014 14.1 2.2 0.016 13.9 2.2 1.0 1 0 0 1 1 1 0 Hamartin protein HNH_2 PF13391.6 EGD97405.1 - 5.5e-12 45.6 0.0 1.1e-11 44.7 0.0 1.5 1 0 0 1 1 1 1 HNH endonuclease Maf PF02545.14 EGD97406.1 - 8e-45 152.7 0.0 9.6e-45 152.4 0.0 1.1 1 0 0 1 1 1 1 Maf-like protein CybS PF05328.12 EGD97407.1 - 1.7e-50 170.1 0.0 2.1e-50 169.9 0.0 1.1 1 0 0 1 1 1 1 CybS, succinate dehydrogenase cytochrome B small subunit ADH_zinc_N PF00107.26 EGD97408.1 - 1.5e-21 76.8 0.0 2e-21 76.3 0.0 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N_2 PF16884.5 EGD97408.1 - 7.3e-17 61.2 0.1 1.5e-16 60.2 0.0 1.6 2 0 0 2 2 2 1 N-terminal domain of oxidoreductase ADH_zinc_N_2 PF13602.6 EGD97408.1 - 1.8e-11 45.2 0.0 3e-11 44.5 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Peptidase_M16 PF00675.20 EGD97410.1 - 8.7e-55 184.8 0.0 3.1e-54 183.0 0.1 1.9 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 EGD97410.1 - 6.1e-40 137.2 0.0 1.3e-38 132.8 0.0 2.2 2 0 0 2 2 2 1 Peptidase M16 inactive domain MFS_1 PF07690.16 EGD97411.1 - 1e-32 113.5 60.7 1.3e-31 109.8 46.2 2.7 1 1 1 2 2 2 2 Major Facilitator Superfamily Nitroreductase PF00881.24 EGD97412.1 - 4e-16 59.5 0.0 4.9e-16 59.2 0.0 1.1 1 0 0 1 1 1 1 Nitroreductase family Phosphoesterase PF04185.14 EGD97412.1 - 0.015 14.5 0.1 0.033 13.4 0.0 1.5 1 1 1 2 2 2 0 Phosphoesterase family Epimerase PF01370.21 EGD97413.1 - 1.3e-19 70.7 0.0 1.6e-19 70.3 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EGD97413.1 - 1.2e-12 47.9 0.0 3.9e-12 46.2 0.0 1.7 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 EGD97413.1 - 1.6e-09 37.2 0.0 2e-09 36.9 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 EGD97413.1 - 0.00029 20.1 0.2 0.46 9.6 0.2 2.3 2 0 0 2 2 2 2 Male sterility protein RmlD_sub_bind PF04321.17 EGD97413.1 - 0.00063 18.9 0.0 0.0012 18.1 0.0 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_10 PF13460.6 EGD97413.1 - 0.0018 18.2 0.0 0.0028 17.6 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding adh_short PF00106.25 EGD97413.1 - 0.0066 15.9 0.0 0.021 14.3 0.0 1.8 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.10 EGD97413.1 - 0.0078 16.1 0.0 0.015 15.2 0.0 1.4 1 0 0 1 1 1 1 KR domain Ldh_1_N PF00056.23 EGD97413.1 - 0.12 12.4 0.0 0.19 11.8 0.0 1.3 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain Fibrillarin PF01269.17 EGD97414.1 - 1.6e-104 347.9 0.0 2e-104 347.7 0.0 1.0 1 0 0 1 1 1 1 Fibrillarin GCD14 PF08704.10 EGD97414.1 - 1.2e-05 25.2 0.0 1.9e-05 24.5 0.0 1.3 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit Methyltr_RsmB-F PF01189.17 EGD97414.1 - 0.031 13.9 0.0 0.066 12.8 0.0 1.5 2 0 0 2 2 2 0 16S rRNA methyltransferase RsmB/F PCMT PF01135.19 EGD97414.1 - 0.046 13.5 0.1 0.074 12.8 0.1 1.4 1 1 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) DUF3455 PF11937.8 EGD97415.1 - 4e-42 144.3 0.0 4.9e-42 144.0 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3455) DUF2990 PF11693.8 EGD97415.1 - 0.00036 20.6 0.0 0.00075 19.6 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2990) CASP_C PF08172.12 EGD97416.1 - 1.4e-89 299.8 0.2 1.4e-89 299.8 0.2 3.4 3 1 0 3 3 3 1 CASP C terminal HTH_Crp_2 PF13545.6 EGD97416.1 - 0.091 12.8 0.8 0.29 11.1 0.8 1.9 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain Vps39_2 PF10367.9 EGD97417.1 - 5.4e-08 33.3 0.2 1.6e-07 31.8 0.0 1.8 2 0 0 2 2 2 1 Vacuolar sorting protein 39 domain 2 CNH PF00780.22 EGD97417.1 - 0.21 11.2 0.0 24 4.4 0.0 2.4 2 0 0 2 2 2 0 CNH domain PALP PF00291.25 EGD97418.1 - 2.4e-57 194.6 0.2 4.3e-57 193.8 0.2 1.3 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Peptidase_M20 PF01546.28 EGD97418.1 - 1.5e-23 83.5 0.1 5.7e-23 81.7 0.0 2.0 2 0 0 2 2 2 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 EGD97418.1 - 4.2e-19 68.5 0.0 1.3e-18 66.9 0.0 1.9 2 0 0 2 2 2 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 EGD97418.1 - 0.00023 20.9 0.0 0.00049 19.8 0.0 1.6 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M42 PF05343.14 EGD97418.1 - 0.0024 16.9 0.0 4.3 6.3 0.0 3.1 3 0 0 3 3 3 2 M42 glutamyl aminopeptidase HTH_10 PF04967.12 EGD97418.1 - 0.19 11.6 0.0 3 7.7 0.0 2.6 2 0 0 2 2 2 0 HTH DNA binding domain UBA_4 PF14555.6 EGD97419.1 - 2.2e-11 43.4 0.0 4.1e-11 42.5 0.0 1.5 1 0 0 1 1 1 1 UBA-like domain UBX PF00789.20 EGD97419.1 - 1.5e-08 34.7 0.0 3.4e-08 33.6 0.0 1.6 1 0 0 1 1 1 1 UBX domain AAR2 PF05282.11 EGD97419.1 - 0.066 12.6 5.8 0.1 12.0 5.8 1.2 1 0 0 1 1 1 0 AAR2 protein CTP_transf_like PF01467.26 EGD97419.1 - 0.082 13.1 0.4 0.18 12.0 0.4 1.6 1 0 0 1 1 1 0 Cytidylyltransferase-like RR_TM4-6 PF06459.12 EGD97419.1 - 0.14 11.9 5.7 0.28 11.0 5.7 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF1682 PF07946.14 EGD97419.1 - 0.63 9.2 12.1 1.1 8.5 12.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) Atg14 PF10186.9 EGD97419.1 - 1.2 8.1 7.8 1.7 7.7 7.8 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Presenilin PF01080.17 EGD97419.1 - 7.4 5.2 9.3 12 4.6 9.3 1.2 1 0 0 1 1 1 0 Presenilin Pan3_PK PF18101.1 EGD97420.1 - 2.6e-62 208.9 0.4 4.1e-62 208.2 0.4 1.3 1 0 0 1 1 1 1 Pan3 Pseudokinase domain Pkinase PF00069.25 EGD97420.1 - 8.2e-05 22.1 0.0 0.00014 21.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain LSM PF01423.22 EGD97421.1 - 3e-20 71.7 1.0 3.9e-20 71.3 1.0 1.2 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EGD97421.1 - 0.028 14.6 0.1 0.047 13.8 0.1 1.4 1 1 0 1 1 1 0 Ataxin 2 SM domain DUF150_C PF17384.2 EGD97421.1 - 0.032 14.4 0.1 0.058 13.5 0.1 1.4 1 0 0 1 1 1 0 RimP C-terminal SH3 domain DUF4175 PF13779.6 EGD97421.1 - 4.1 5.2 10.3 4.6 5.0 10.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Zn_clus PF00172.18 EGD97422.1 - 0.64 10.2 11.9 1.8 8.8 11.9 1.7 1 1 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain FKBP_N PF01346.18 EGD97422.1 - 1.2 10.1 7.2 0.97 10.4 3.3 2.5 2 0 0 2 2 2 0 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase Dioxygenase_C PF00775.21 EGD97423.1 - 7.8e-42 142.8 0.0 1.1e-41 142.3 0.0 1.2 1 0 0 1 1 1 1 Dioxygenase Dioxygenase_N PF04444.14 EGD97423.1 - 6.6e-31 106.0 0.0 4.8e-30 103.2 0.0 2.1 2 0 0 2 2 2 1 Catechol dioxygenase N terminus CarboxypepD_reg PF13620.6 EGD97423.1 - 0.027 14.7 0.0 0.064 13.5 0.0 1.6 1 0 0 1 1 1 0 Carboxypeptidase regulatory-like domain Ribosomal_L22 PF00237.19 EGD97424.1 - 2.8e-40 136.7 0.1 3.7e-40 136.3 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e 2-Hacid_dh_C PF02826.19 EGD97425.1 - 9.5e-56 188.0 0.0 1.3e-55 187.5 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EGD97425.1 - 7.5e-18 64.5 0.0 9e-18 64.2 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 EGD97425.1 - 0.0033 17.6 0.1 0.0071 16.5 0.1 1.5 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase AdoHcyase_NAD PF00670.21 EGD97425.1 - 0.026 14.6 0.0 0.05 13.7 0.0 1.4 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain ADH_N PF08240.12 EGD97426.1 - 1.9e-26 92.1 0.1 3.2e-26 91.4 0.1 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EGD97426.1 - 4e-12 46.2 0.0 7.8e-12 45.3 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 EGD97426.1 - 1.5e-07 31.1 0.2 0.024 14.1 0.2 2.6 2 1 0 2 2 2 2 Glucose dehydrogenase C-terminus UDPG_MGDP_dh_N PF03721.14 EGD97426.1 - 0.049 13.2 0.0 0.08 12.5 0.0 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Sacchrp_dh_NADP PF03435.18 EGD97426.1 - 0.05 13.9 0.0 0.11 12.8 0.0 1.6 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain ApbA PF02558.16 EGD97426.1 - 0.072 12.7 0.0 0.12 12.0 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Ldh_1_N PF00056.23 EGD97426.1 - 0.11 12.6 0.0 0.21 11.7 0.0 1.5 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain adh_short PF00106.25 EGD97427.1 - 1.6e-44 151.8 0.7 2e-44 151.4 0.7 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EGD97427.1 - 1.9e-43 148.7 0.5 2.2e-43 148.5 0.5 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EGD97427.1 - 3.6e-09 36.8 0.5 5.2e-09 36.3 0.5 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EGD97427.1 - 0.00095 18.7 0.1 0.0052 16.3 0.1 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family DUF1776 PF08643.10 EGD97427.1 - 0.004 16.6 0.0 0.0058 16.0 0.0 1.2 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) NAD_binding_10 PF13460.6 EGD97427.1 - 0.0063 16.4 0.2 0.022 14.6 0.1 1.9 1 1 0 1 1 1 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 EGD97427.1 - 0.019 14.4 0.0 0.031 13.7 0.0 1.3 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Fungal_trans PF04082.18 EGD97428.1 - 1.4e-07 30.8 3.8 3.2e-07 29.6 0.0 3.0 2 1 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EGD97428.1 - 7e-06 26.1 11.1 1.2e-05 25.3 11.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Presenilin PF01080.17 EGD97428.1 - 0.58 8.9 3.3 1 8.1 3.3 1.3 1 0 0 1 1 1 0 Presenilin DUF4614 PF15391.6 EGD97428.1 - 3 7.8 12.3 20 5.1 0.0 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4614) adh_short_C2 PF13561.6 EGD97430.1 - 1.2e-30 106.9 0.1 1.2e-30 106.8 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EGD97430.1 - 2e-16 60.1 0.0 2.6e-16 59.7 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase Glyco_transf_5 PF08323.11 EGD97430.1 - 0.006 16.3 0.0 0.006 16.3 0.0 1.1 1 0 0 1 1 1 1 Starch synthase catalytic domain Ferric_reduct PF01794.19 EGD97431.1 - 2.4e-27 95.5 7.5 2.4e-27 95.5 7.5 1.9 2 0 0 2 2 2 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.12 EGD97431.1 - 3.9e-16 59.5 0.1 1.2e-13 51.4 0.0 2.7 2 1 0 2 2 2 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 EGD97431.1 - 2.4e-10 40.4 0.0 1.3e-05 25.3 0.0 2.4 2 0 0 2 2 2 2 FAD-binding domain NAD_binding_1 PF00175.21 EGD97431.1 - 0.046 14.4 0.0 0.21 12.2 0.0 2.2 1 1 0 1 1 1 0 Oxidoreductase NAD-binding domain GAT PF03127.14 EGD97432.1 - 2.2e-20 72.7 1.0 3.4e-20 72.1 0.3 1.7 2 0 0 2 2 2 1 GAT domain VHS PF00790.19 EGD97432.1 - 0.038 13.8 0.3 0.22 11.4 0.0 2.3 3 0 0 3 3 3 0 VHS domain Pyr_redox_2 PF07992.14 EGD97433.1 - 2.9e-35 121.9 0.0 1.1e-31 110.2 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EGD97433.1 - 1e-08 35.6 0.0 6.7e-08 33.0 0.0 2.4 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DUF5412 PF17428.2 EGD97433.1 - 0.13 12.1 0.1 0.27 11.1 0.1 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5412) DUF3408 PF11888.8 EGD97434.1 - 0.24 11.5 3.0 8.9 6.5 1.7 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3408) Fungal_trans_2 PF11951.8 EGD97437.1 - 6.3e-08 31.8 0.0 2.5e-05 23.3 0.1 2.2 2 0 0 2 2 2 2 Fungal specific transcription factor domain Zn_clus PF00172.18 EGD97437.1 - 3.1e-07 30.4 10.0 6.4e-07 29.4 10.0 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Pectate_lyase_3 PF12708.7 EGD97440.1 - 7.3e-102 339.7 14.0 2.1e-86 289.2 7.1 2.8 3 0 0 3 3 3 2 Pectate lyase superfamily protein End_N_terminal PF12218.8 EGD97440.1 - 3.5e-07 29.8 3.5 0.00046 19.8 0.1 3.2 3 0 0 3 3 3 2 N terminal extension of bacteriophage endosialidase Aminotran_1_2 PF00155.21 EGD97442.1 - 4.3e-09 36.0 0.0 0.00088 18.5 0.0 2.5 2 1 0 2 2 2 2 Aminotransferase class I and II FOG_N PF15888.5 EGD97442.1 - 0.19 12.1 0.0 0.37 11.2 0.0 1.4 1 0 0 1 1 1 0 Folded gastrulation N-terminus Ribosomal_L10 PF00466.20 EGD97444.1 - 8.8e-17 61.1 0.0 2.1e-16 59.9 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein L10 RL10P_insert PF17777.1 EGD97444.1 - 1.8e-16 59.9 0.0 3.5e-16 58.9 0.0 1.5 1 0 0 1 1 1 1 Insertion domain in 60S ribosomal protein L10P TIM PF00121.18 EGD97445.1 - 8.6e-90 300.3 0.5 9.8e-90 300.2 0.5 1.0 1 0 0 1 1 1 1 Triosephosphate isomerase DUF3860 PF12976.7 EGD97445.1 - 0.043 13.8 1.1 0.072 13.1 0.2 1.8 2 0 0 2 2 2 0 Domain of Unknown Function with PDB structure (DUF3860) MDM10 PF12519.8 EGD97446.1 - 1.4e-144 482.5 3.6 2.8e-126 422.1 2.0 2.0 1 1 1 2 2 2 2 Mitochondrial distribution and morphology protein 10 YjeF_N PF03853.15 EGD97447.1 - 1.4e-33 116.2 0.1 2.1e-33 115.6 0.1 1.3 1 0 0 1 1 1 1 YjeF-related protein N-terminus FDF PF09532.10 EGD97447.1 - 1.1e-06 29.5 0.7 1.1e-06 29.5 0.7 2.4 3 0 0 3 3 3 1 FDF domain OCD_Mu_crystall PF02423.15 EGD97447.1 - 0.045 12.7 0.2 1.1 8.1 0.0 2.1 2 0 0 2 2 2 0 Ornithine cyclodeaminase/mu-crystallin family Pkinase PF00069.25 EGD97448.1 - 5.8e-16 58.7 0.2 2.1e-13 50.3 0.1 3.0 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EGD97448.1 - 4.1e-10 39.4 0.0 2.4e-07 30.3 0.0 3.1 3 0 0 3 3 3 2 Protein tyrosine kinase RIO1 PF01163.22 EGD97448.1 - 5.1e-06 26.2 0.1 9e-06 25.4 0.1 1.3 1 0 0 1 1 1 1 RIO1 family Pro_isomerase PF00160.21 EGD97449.1 - 1.7e-38 132.4 0.0 3.1e-38 131.5 0.0 1.5 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD zf-NOSIP PF15906.5 EGD97449.1 - 0.00017 21.6 0.0 0.00046 20.3 0.0 1.7 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein U-box PF04564.15 EGD97449.1 - 0.00066 19.8 0.0 0.0028 17.8 0.0 2.0 1 1 0 1 1 1 1 U-box domain Rtf2 PF04641.12 EGD97449.1 - 0.0021 17.4 1.0 0.0021 17.4 1.0 2.4 2 1 0 2 2 2 1 Rtf2 RING-finger DFF40 PF09230.10 EGD97449.1 - 0.12 12.0 0.0 0.2 11.2 0.0 1.3 1 0 0 1 1 1 0 DNA fragmentation factor 40 kDa DUF3340 PF11818.8 EGD97449.1 - 0.84 9.8 7.3 0.059 13.5 1.8 1.8 2 0 0 2 2 2 0 C-terminal domain of tail specific protease (DUF3340) DUF2204 PF09970.9 EGD97450.1 - 0.066 12.9 0.1 0.091 12.4 0.1 1.2 1 0 0 1 1 1 0 Nucleotidyl transferase of unknown function (DUF2204) PIF1 PF05970.14 EGD97453.1 - 2.4e-52 178.3 0.1 2.4e-47 161.8 0.1 2.2 1 1 1 2 2 2 2 PIF1-like helicase AAA_30 PF13604.6 EGD97453.1 - 9.5e-25 87.4 0.0 1.7e-24 86.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EGD97453.1 - 2.1e-11 44.4 0.0 2.3e-10 41.0 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 EGD97453.1 - 1.6e-06 28.4 0.0 4.8e-06 26.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_7 PF12775.7 EGD97453.1 - 6.7e-05 22.5 0.0 0.00017 21.2 0.0 1.6 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA PF00004.29 EGD97453.1 - 0.00019 21.8 0.3 0.00063 20.2 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Herpes_Helicase PF02689.14 EGD97453.1 - 0.00023 19.3 0.0 0.001 17.1 0.0 1.9 2 0 0 2 2 2 1 Helicase UvrD_C_2 PF13538.6 EGD97453.1 - 0.00025 20.8 0.1 0.00072 19.3 0.1 1.8 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain Viral_helicase1 PF01443.18 EGD97453.1 - 0.0022 17.8 0.1 0.56 9.9 0.0 2.7 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase AAA_14 PF13173.6 EGD97453.1 - 0.0056 16.7 0.2 0.034 14.2 0.1 2.4 2 1 0 2 2 2 1 AAA domain AAA_5 PF07728.14 EGD97453.1 - 0.0066 16.4 0.0 0.022 14.8 0.0 1.9 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EGD97453.1 - 0.011 16.1 0.0 0.039 14.3 0.0 1.9 1 0 0 1 1 1 0 AAA ATPase domain PhoH PF02562.16 EGD97453.1 - 0.015 14.8 0.2 0.05 13.1 0.0 2.0 2 0 0 2 2 2 0 PhoH-like protein DUF2075 PF09848.9 EGD97453.1 - 0.032 13.5 0.0 0.12 11.6 0.0 2.2 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) T2SSE PF00437.20 EGD97453.1 - 0.046 12.8 0.0 0.086 11.9 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein NB-ARC PF00931.22 EGD97453.1 - 0.047 12.9 0.1 0.089 12.0 0.1 1.4 1 0 0 1 1 1 0 NB-ARC domain RNA_helicase PF00910.22 EGD97453.1 - 0.059 13.8 0.1 0.32 11.4 0.0 2.4 2 1 0 2 2 1 0 RNA helicase DUF5605 PF18310.1 EGD97453.1 - 0.064 13.2 0.0 0.26 11.2 0.0 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5605) RsgA_GTPase PF03193.16 EGD97453.1 - 0.075 12.9 0.1 0.15 12.0 0.1 1.5 1 0 0 1 1 1 0 RsgA GTPase ATPase_2 PF01637.18 EGD97453.1 - 0.11 12.4 0.7 0.58 10.0 0.7 2.1 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea PTCB-BRCT PF12738.7 EGD97454.1 - 4.5e-45 151.4 0.6 9.2e-22 76.8 0.1 3.5 3 0 0 3 3 3 3 twin BRCT domain BRCT PF00533.26 EGD97454.1 - 1.6e-28 98.9 0.0 4.3e-11 43.0 0.1 4.3 4 0 0 4 4 4 3 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 EGD97454.1 - 3.2e-10 40.3 0.0 0.00025 21.4 0.0 4.0 4 0 0 4 4 4 3 BRCT domain, a BRCA1 C-terminus domain LIG3_BRCT PF16759.5 EGD97454.1 - 3.2e-05 24.1 2.2 0.2 11.9 0.0 3.9 4 0 0 4 4 4 2 DNA ligase 3 BRCT domain Dynamin_N PF00350.23 EGD97455.1 - 2.9e-17 63.2 4.6 2.9e-17 63.2 0.1 2.9 3 1 0 3 3 3 1 Dynamin family MMR_HSR1 PF01926.23 EGD97455.1 - 1.7e-10 41.0 0.0 1.1e-08 35.2 0.0 3.3 3 1 0 3 3 3 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EGD97455.1 - 1.3e-07 31.4 0.1 9.1e-05 22.1 0.1 2.7 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain DUF2205 PF10224.9 EGD97455.1 - 0.034 14.1 0.1 0.12 12.4 0.1 1.9 1 0 0 1 1 1 0 Short coiled-coil protein FeoB_N PF02421.18 EGD97455.1 - 0.065 12.8 0.4 39 3.7 0.0 3.8 5 0 0 5 5 5 0 Ferrous iron transport protein B AAA_18 PF13238.6 EGD97455.1 - 0.067 13.7 0.0 0.58 10.7 0.0 2.4 2 0 0 2 2 2 0 AAA domain TsaE PF02367.17 EGD97455.1 - 0.098 12.7 0.0 0.23 11.5 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Roc PF08477.13 EGD97455.1 - 0.1 12.8 0.1 3 8.1 0.0 2.8 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase AAA_29 PF13555.6 EGD97455.1 - 0.15 11.8 0.0 0.36 10.6 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain Snf7 PF03357.21 EGD97456.1 - 3.4e-35 121.2 17.5 2.4e-34 118.4 15.8 2.0 2 0 0 2 2 2 1 Snf7 DUF3958 PF13125.6 EGD97456.1 - 4.9 7.4 12.4 0.21 11.8 4.1 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF3958) Remorin_C PF03763.13 EGD97456.1 - 9.5 6.2 13.3 0.59 10.0 7.8 2.0 2 1 0 2 2 2 0 Remorin, C-terminal region PP2C PF00481.21 EGD97457.1 - 9.1e-63 212.3 1.6 7.1e-50 170.0 0.0 3.9 2 1 1 3 3 3 2 Protein phosphatase 2C AAA_33 PF13671.6 EGD97457.1 - 0.023 14.9 0.0 0.093 12.9 0.0 2.1 2 0 0 2 2 2 0 AAA domain Mhr1 PF12829.7 EGD97458.1 - 1.3e-27 95.7 0.1 2.8e-27 94.6 0.1 1.6 1 0 0 1 1 1 1 Transcriptional regulation of mitochondrial recombination RR_TM4-6 PF06459.12 EGD97458.1 - 5.3 6.8 10.7 8.8 6.1 10.7 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Atg14 PF10186.9 EGD97459.1 - 4.7e-17 62.1 0.0 9.6e-17 61.0 0.0 1.4 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 VPS38 PF17649.1 EGD97459.1 - 0.0011 18.0 3.5 0.019 13.8 0.0 2.9 3 0 0 3 3 3 2 Vacuolar protein sorting 38 Zn_clus PF00172.18 EGD97460.1 - 5.5e-07 29.6 14.8 9.3e-07 28.9 14.8 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain F-box-like PF12937.7 EGD97461.1 - 1.2e-05 25.1 0.7 2.6e-05 24.0 0.2 1.8 2 0 0 2 2 2 1 F-box-like PalH PF08733.10 EGD97462.1 - 2.1e-113 378.7 0.0 2.8e-113 378.3 0.0 1.1 1 0 0 1 1 1 1 PalH/RIM21 TIP120 PF08623.10 EGD97464.1 - 1.6e-66 223.3 0.0 5.3e-64 215.0 0.0 3.5 3 0 0 3 3 3 1 TATA-binding protein interacting (TIP20) HEAT PF02985.22 EGD97464.1 - 2.4e-14 52.2 5.2 0.13 12.6 0.0 9.3 10 0 0 10 10 9 3 HEAT repeat HEAT_2 PF13646.6 EGD97464.1 - 3.4e-10 40.2 6.9 0.46 10.9 0.0 7.7 7 2 2 9 9 8 3 HEAT repeats HEAT_EZ PF13513.6 EGD97464.1 - 4.6e-07 30.2 11.7 2.3 8.8 0.0 10.0 10 1 2 12 12 12 2 HEAT-like repeat Cnd1 PF12717.7 EGD97464.1 - 8.8e-07 29.1 0.1 0.00016 21.7 0.0 3.4 3 0 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 EGD97464.1 - 3.9e-05 22.4 1.8 1.7 7.1 0.0 5.2 4 2 1 5 5 5 2 Adaptin N terminal region RTP1_C1 PF10363.9 EGD97464.1 - 0.0011 19.2 0.5 0.13 12.4 0.0 3.8 3 0 0 3 3 3 1 Required for nuclear transport of RNA pol II C-terminus 1 Vac14_Fab1_bd PF12755.7 EGD97464.1 - 0.0019 18.8 0.0 7.1 7.3 0.0 5.6 6 2 0 6 6 6 1 Vacuolar 14 Fab1-binding region DUF3295 PF11702.8 EGD97464.1 - 0.016 14.6 0.2 0.028 13.8 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3295) DRIM PF07539.12 EGD97464.1 - 0.058 11.7 3.5 22 3.2 0.0 4.7 4 1 0 5 5 5 0 Down-regulated in metastasis Arm PF00514.23 EGD97464.1 - 1 9.5 6.9 25 5.1 0.0 5.5 6 0 0 6 6 5 0 Armadillo/beta-catenin-like repeat MMS19_C PF12460.8 EGD97464.1 - 1.2 8.1 11.9 1.2 8.2 1.8 4.4 5 1 0 5 5 5 0 RNAPII transcription regulator C-terminal HEAT_PBS PF03130.16 EGD97464.1 - 9.5 7.2 10.0 0.87 10.4 0.3 4.7 5 0 0 5 5 4 0 PBS lyase HEAT-like repeat REC114-like PF15165.6 EGD97465.1 - 0.37 10.5 2.5 0.61 9.8 2.5 1.4 1 0 0 1 1 1 0 Meiotic recombination protein REC114-like SAPS PF04499.15 EGD97465.1 - 2.5 6.8 6.2 2.6 6.7 6.2 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Mitofilin PF09731.9 EGD97465.1 - 3.2 6.5 26.7 3.8 6.2 26.7 1.0 1 0 0 1 1 1 0 Mitochondrial inner membrane protein TRAM_LAG1_CLN8 PF03798.16 EGD97466.1 - 4.6e-39 134.2 18.4 7.5e-39 133.5 18.4 1.4 1 0 0 1 1 1 1 TLC domain TRAM1 PF08390.11 EGD97466.1 - 1.2e-21 76.2 0.0 3.3e-21 74.7 0.0 1.8 1 0 0 1 1 1 1 TRAM1-like protein Sugar_tr PF00083.24 EGD97467.1 - 1.2e-107 360.6 15.9 1.5e-107 360.3 15.9 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EGD97467.1 - 2.6e-26 92.4 32.6 7.6e-25 87.6 22.8 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_5 PF05631.14 EGD97467.1 - 5.2e-06 25.6 0.3 1e-05 24.7 0.3 1.4 1 0 0 1 1 1 1 Sugar-tranasporters, 12 TM DUF2530 PF10745.9 EGD97467.1 - 2.3 8.5 7.5 0.6 10.4 2.6 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2530) Transglut_core PF01841.19 EGD97469.1 - 2.9e-14 53.5 0.0 6.1e-14 52.4 0.0 1.5 1 0 0 1 1 1 1 Transglutaminase-like superfamily Ras PF00071.22 EGD97470.1 - 8.4e-31 106.8 0.2 1.2e-30 106.2 0.2 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EGD97470.1 - 3.3e-23 82.2 0.1 3.3e-23 82.2 0.1 1.7 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EGD97470.1 - 2.2e-06 27.2 0.1 3.7e-06 26.5 0.1 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EGD97470.1 - 0.00051 19.5 0.2 0.00051 19.5 0.2 1.5 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region DLIC PF05783.11 EGD97470.1 - 0.0017 17.3 0.1 1 8.1 0.0 2.3 2 0 0 2 2 2 2 Dynein light intermediate chain (DLIC) CrgA PF06781.12 EGD97470.1 - 0.05 13.7 0.1 0.12 12.4 0.1 1.6 1 0 0 1 1 1 0 Cell division protein CrgA TFIIA PF03153.13 EGD97470.1 - 0.1 12.6 28.6 0.14 12.1 28.6 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit LAP1C PF05609.12 EGD97470.1 - 0.13 11.3 13.7 0.19 10.8 13.7 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) SRP9-21 PF05486.12 EGD97470.1 - 1.7 9.1 5.8 0.43 11.0 0.5 2.5 2 0 0 2 2 2 0 Signal recognition particle 9 kDa protein (SRP9) CAF1C_H4-bd PF12265.8 EGD97471.1 - 7.8e-16 58.1 0.1 3.7e-15 55.9 0.0 2.1 2 0 0 2 2 2 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 EGD97471.1 - 8.4e-14 51.7 7.9 2.7e-06 28.0 0.1 4.5 4 0 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EGD97471.1 - 2.6e-07 30.8 1.6 0.0025 18.1 0.3 3.2 2 2 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EGD97471.1 - 0.023 13.4 0.7 0.19 10.3 0.1 2.2 2 0 0 2 2 2 0 Nucleoporin Nup120/160 Vpu PF00558.19 EGD97471.1 - 0.32 10.8 1.7 0.65 9.8 1.7 1.4 1 0 0 1 1 1 0 Vpu protein Fungal_trans PF04082.18 EGD97475.1 - 8.4e-23 80.7 0.7 1.6e-22 79.9 0.7 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-C2H2 PF00096.26 EGD97475.1 - 2.5e-09 37.1 14.0 7.4e-05 23.0 2.1 3.0 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EGD97475.1 - 1.5e-06 28.3 12.4 3.2e-06 27.3 6.6 2.8 2 0 0 2 2 2 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 EGD97475.1 - 0.00032 21.3 13.1 0.042 14.7 2.0 3.1 2 0 0 2 2 2 2 C2H2-type zinc finger Utp8 PF10395.9 EGD97476.1 - 1.1e-08 34.1 0.2 8.6e-08 31.2 0.0 2.3 3 0 0 3 3 3 1 Utp8 family AAA PF00004.29 EGD97477.1 - 5.7e-08 33.2 3.2 2.2e-07 31.4 0.9 2.9 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 EGD97477.1 - 9.9e-08 32.1 0.1 0.001 19.0 0.0 3.3 2 1 1 3 3 3 2 Rad17 P-loop domain AAA_16 PF13191.6 EGD97477.1 - 0.0026 18.2 0.0 0.0076 16.6 0.0 1.8 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EGD97477.1 - 0.013 15.8 0.0 0.055 13.7 0.0 2.1 1 0 0 1 1 1 0 AAA domain TIP49 PF06068.13 EGD97477.1 - 0.22 10.7 0.1 0.36 10.0 0.1 1.2 1 0 0 1 1 1 0 TIP49 P-loop domain DUF4869 PF16163.5 EGD97478.1 - 0.074 12.8 0.0 0.1 12.3 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4869) Tmemb_cc2 PF10267.9 EGD97479.1 - 0.0068 15.6 1.9 0.0085 15.3 1.8 1.3 1 1 0 1 1 1 1 Predicted transmembrane and coiled-coil 2 protein Prefoldin_3 PF13758.6 EGD97479.1 - 0.072 13.1 1.7 0.19 11.8 0.3 2.2 2 0 0 2 2 2 0 Prefoldin subunit Nha1_C PF08619.10 EGD97480.1 - 2.7e-80 270.9 15.1 3.3e-80 270.6 15.1 1.1 1 0 0 1 1 1 1 Alkali metal cation/H+ antiporter Nha1 C terminus Na_H_Exchanger PF00999.21 EGD97480.1 - 6.8e-73 245.6 19.3 8.1e-73 245.4 19.3 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family YrhC PF14143.6 EGD97480.1 - 0.022 14.8 3.1 0.022 14.8 0.4 2.4 2 0 0 2 2 2 0 YrhC-like protein DUF21 PF01595.20 EGD97480.1 - 9.6 5.9 8.4 0.46 10.2 2.4 1.9 2 0 0 2 2 2 0 Cyclin M transmembrane N-terminal domain SAM_2 PF07647.17 EGD97481.1 - 3.1e-15 56.0 0.0 5.1e-15 55.3 0.0 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) RA PF00788.23 EGD97481.1 - 5.3e-12 46.2 0.1 1.3e-11 44.9 0.0 1.7 2 0 0 2 2 2 1 Ras association (RalGDS/AF-6) domain SAM_1 PF00536.30 EGD97481.1 - 7.8e-12 45.5 0.0 1.2e-11 44.9 0.0 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_4 PF18017.1 EGD97481.1 - 0.01 15.8 0.0 0.019 14.9 0.0 1.3 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) EnY2 PF10163.9 EGD97482.1 - 1.6e-05 25.2 0.0 3e-05 24.3 0.0 1.6 1 0 0 1 1 1 1 Transcription factor e(y)2 AAA PF00004.29 EGD97483.1 - 1e-96 320.4 0.0 2e-47 160.9 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EGD97483.1 - 2.5e-24 84.8 5.5 6.7e-13 48.2 0.3 3.3 2 1 0 2 2 2 2 AAA+ lid domain CDC48_N PF02359.18 EGD97483.1 - 1e-18 67.3 1.4 2.3e-18 66.1 0.6 2.1 2 0 0 2 2 1 1 Cell division protein 48 (CDC48), N-terminal domain AAA_2 PF07724.14 EGD97483.1 - 3e-14 53.5 0.0 1.1e-07 32.2 0.0 2.9 2 1 0 2 2 2 2 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 EGD97483.1 - 8.9e-14 51.5 0.0 1.4e-05 24.9 0.0 3.4 4 1 0 4 4 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_33 PF13671.6 EGD97483.1 - 2.6e-12 47.1 0.0 2.3e-05 24.6 0.0 3.2 3 0 0 3 3 3 2 AAA domain AAA_16 PF13191.6 EGD97483.1 - 3.7e-11 43.7 0.0 0.00014 22.2 0.0 4.3 2 2 1 3 3 3 2 AAA ATPase domain AAA_5 PF07728.14 EGD97483.1 - 3.4e-10 40.1 0.6 4.5e-05 23.5 0.1 3.8 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EGD97483.1 - 6.4e-09 36.2 0.5 0.053 13.8 0.0 4.1 2 2 1 3 3 3 2 AAA domain TIP49 PF06068.13 EGD97483.1 - 7.4e-09 35.3 0.1 0.0015 17.8 0.0 2.6 2 1 0 2 2 2 2 TIP49 P-loop domain CDC48_2 PF02933.17 EGD97483.1 - 5e-08 32.6 0.0 1.1e-07 31.5 0.0 1.6 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), domain 2 IstB_IS21 PF01695.17 EGD97483.1 - 3.1e-07 30.3 0.0 0.02 14.7 0.0 2.6 2 0 0 2 2 2 2 IstB-like ATP binding protein Mg_chelatase PF01078.21 EGD97483.1 - 4.4e-07 29.5 0.4 0.033 13.6 0.0 2.6 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 EGD97483.1 - 1.1e-06 29.2 0.0 0.055 14.0 0.0 3.0 3 0 0 3 3 2 2 AAA domain ATPase PF06745.13 EGD97483.1 - 1.1e-06 28.2 0.4 0.64 9.3 0.0 3.5 3 0 0 3 3 3 2 KaiC Vps4_C PF09336.10 EGD97483.1 - 1.7e-06 27.9 0.4 1.7e-05 24.7 0.1 2.5 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain RNA_helicase PF00910.22 EGD97483.1 - 1.9e-06 28.2 0.0 0.028 14.8 0.0 2.8 2 0 0 2 2 2 2 RNA helicase AAA_14 PF13173.6 EGD97483.1 - 2.5e-06 27.5 0.0 0.023 14.7 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_25 PF13481.6 EGD97483.1 - 4.4e-06 26.4 6.5 0.43 10.1 0.1 4.9 3 2 1 5 5 5 2 AAA domain AAA_7 PF12775.7 EGD97483.1 - 7.1e-06 25.7 0.1 0.035 13.6 0.0 2.9 2 1 0 2 2 2 2 P-loop containing dynein motor region AAA_28 PF13521.6 EGD97483.1 - 3e-05 24.3 0.0 0.3 11.3 0.0 2.8 2 0 0 2 2 2 2 AAA domain DUF815 PF05673.13 EGD97483.1 - 3.7e-05 23.0 0.0 0.0086 15.3 0.0 2.6 2 0 0 2 2 2 1 Protein of unknown function (DUF815) ABC_tran PF00005.27 EGD97483.1 - 4.8e-05 23.9 0.0 0.26 11.8 0.0 3.3 2 1 0 2 2 2 1 ABC transporter Sigma54_activat PF00158.26 EGD97483.1 - 7e-05 22.6 0.1 0.75 9.5 0.0 3.3 2 2 0 2 2 2 2 Sigma-54 interaction domain PhoH PF02562.16 EGD97483.1 - 8.3e-05 22.1 0.4 0.35 10.3 0.0 2.5 2 0 0 2 2 2 2 PhoH-like protein AAA_24 PF13479.6 EGD97483.1 - 8.4e-05 22.4 0.0 0.66 9.7 0.0 2.8 3 0 0 3 3 2 2 AAA domain Parvo_NS1 PF01057.17 EGD97483.1 - 0.00011 21.5 0.1 0.1 11.7 0.0 2.3 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 Bac_DnaA PF00308.18 EGD97483.1 - 0.00026 20.9 0.0 0.69 9.7 0.0 2.8 3 0 0 3 3 2 2 Bacterial dnaA protein AAA_11 PF13086.6 EGD97483.1 - 0.00031 20.6 0.0 0.41 10.4 0.0 2.7 2 1 0 2 2 2 2 AAA domain ResIII PF04851.15 EGD97483.1 - 0.00041 20.4 0.0 0.11 12.5 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_17 PF13207.6 EGD97483.1 - 0.00045 20.6 0.0 0.88 10.0 0.0 3.1 2 0 0 2 2 2 1 AAA domain TsaE PF02367.17 EGD97483.1 - 0.0006 19.8 0.0 0.62 10.1 0.0 2.5 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_3 PF07726.11 EGD97483.1 - 0.00072 19.4 0.0 1.6 8.6 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) DUF2075 PF09848.9 EGD97483.1 - 0.0018 17.6 0.0 0.84 8.8 0.0 2.3 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) AAA_30 PF13604.6 EGD97483.1 - 0.0039 16.9 0.6 2.6 7.7 0.0 2.5 2 0 0 2 2 2 1 AAA domain ATPase_2 PF01637.18 EGD97483.1 - 0.0044 17.0 0.0 11 5.8 0.0 3.6 3 1 0 3 3 3 0 ATPase domain predominantly from Archaea AAA_19 PF13245.6 EGD97483.1 - 0.0054 17.1 0.7 6.9 7.0 0.0 3.5 3 1 0 4 4 2 0 AAA domain NACHT PF05729.12 EGD97483.1 - 0.0071 16.3 0.1 1.6 8.6 0.0 3.0 3 0 0 3 3 3 1 NACHT domain Viral_helicase1 PF01443.18 EGD97483.1 - 0.008 15.9 0.0 0.66 9.7 0.0 2.4 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase UFD1 PF03152.14 EGD97483.1 - 0.0086 15.6 0.0 0.069 12.6 0.0 2.1 1 1 1 2 2 2 1 Ubiquitin fusion degradation protein UFD1 KAP_NTPase PF07693.14 EGD97483.1 - 0.019 14.2 0.0 0.73 9.0 0.0 2.6 2 1 0 2 2 2 0 KAP family P-loop domain Sigma54_activ_2 PF14532.6 EGD97483.1 - 0.022 14.9 0.0 3.7 7.7 0.0 2.6 2 0 0 2 2 2 0 Sigma-54 interaction domain Zeta_toxin PF06414.12 EGD97483.1 - 0.026 13.8 1.5 6.2 6.0 0.0 3.1 4 0 0 4 4 3 0 Zeta toxin NB-ARC PF00931.22 EGD97483.1 - 0.026 13.7 0.0 1.9 7.6 0.0 2.6 2 0 0 2 2 2 0 NB-ARC domain IPT PF01745.16 EGD97483.1 - 0.029 13.8 0.1 2.3 7.5 0.0 2.3 2 0 0 2 2 2 0 Isopentenyl transferase eIF-1a PF01176.19 EGD97483.1 - 0.03 14.1 0.8 1.1 9.2 0.7 2.8 2 1 0 2 2 1 0 Translation initiation factor 1A / IF-1 NTPase_1 PF03266.15 EGD97483.1 - 0.051 13.5 3.0 3.7 7.4 0.0 4.1 5 0 0 5 5 4 0 NTPase T2SSE PF00437.20 EGD97483.1 - 0.082 12.0 0.0 3.2 6.7 0.0 2.4 2 0 0 2 2 2 0 Type II/IV secretion system protein Cytidylate_kin PF02224.18 EGD97483.1 - 0.084 12.6 0.2 18 5.0 0.0 3.1 3 0 0 3 3 2 0 Cytidylate kinase LXG PF04740.12 EGD97483.1 - 0.089 12.5 0.1 0.2 11.3 0.1 1.5 1 0 0 1 1 1 0 LXG domain of WXG superfamily AAA_6 PF12774.7 EGD97483.1 - 0.11 11.4 0.1 11 4.9 0.0 2.4 2 0 0 2 2 2 0 Hydrolytic ATP binding site of dynein motor region Zot PF05707.12 EGD97483.1 - 0.14 11.8 0.0 7 6.2 0.0 3.0 2 1 0 2 2 2 0 Zonular occludens toxin (Zot) PsiF_repeat PF07769.14 EGD97486.1 - 0.068 13.1 0.1 0.21 11.5 0.1 1.8 2 0 0 2 2 2 0 psiF repeat PEX11 PF05648.14 EGD97488.1 - 3.7e-17 62.6 1.8 3.9e-14 52.7 0.3 2.1 2 0 0 2 2 2 2 Peroxisomal biogenesis factor 11 (PEX11) Mpv17_PMP22 PF04117.12 EGD97491.1 - 9.2e-14 51.4 1.7 7.9e-12 45.2 0.7 2.3 2 0 0 2 2 2 2 Mpv17 / PMP22 family CKAP2_C PF15297.6 EGD97491.1 - 0.091 11.8 0.0 0.15 11.1 0.0 1.3 1 0 0 1 1 1 0 Cytoskeleton-associated protein 2 C-terminus Sin_N PF04801.13 EGD97491.1 - 0.14 11.3 0.1 0.23 10.6 0.1 1.3 1 0 0 1 1 1 0 Sin-like protein conserved region SprT-like PF10263.9 EGD97492.1 - 9.8e-09 35.1 0.0 9.8e-09 35.1 0.0 1.7 2 0 0 2 2 2 1 SprT-like family SUIM_assoc PF16619.5 EGD97492.1 - 0.0019 18.2 1.0 0.0047 17.0 1.0 1.6 1 1 0 1 1 1 1 Unstructured region C-term to UIM in Ataxin3 Cullin_binding PF03556.15 EGD97493.1 - 3.8e-31 108.0 3.6 5.2e-31 107.6 3.6 1.2 1 0 0 1 1 1 1 Cullin binding UPF0113_N PF17833.1 EGD97494.1 - 2.8e-25 88.7 0.0 3.7e-25 88.3 0.0 1.2 1 0 0 1 1 1 1 UPF0113 Pre-PUA domain UPF0113 PF03657.13 EGD97494.1 - 1.7e-21 76.3 0.0 2.4e-21 75.8 0.0 1.2 1 0 0 1 1 1 1 UPF0113 PUA domain PUA PF01472.20 EGD97494.1 - 0.12 12.4 0.0 0.18 11.8 0.0 1.3 1 0 0 1 1 1 0 PUA domain NOC3p PF07540.11 EGD97495.1 - 2.8e-29 101.4 0.4 1.5e-28 99.1 0.3 2.4 2 0 0 2 2 2 1 Nucleolar complex-associated protein CBF PF03914.17 EGD97495.1 - 4.8e-26 91.8 1.7 7.3e-25 88.0 0.0 2.9 2 1 1 3 3 3 1 CBF/Mak21 family Adaptin_N PF01602.20 EGD97495.1 - 0.012 14.2 1.2 4.8 5.6 0.0 3.0 3 0 0 3 3 3 0 Adaptin N terminal region Orbi_VP1 PF05788.12 EGD97495.1 - 0.046 11.3 0.2 0.068 10.8 0.2 1.1 1 0 0 1 1 1 0 Orbivirus RNA-dependent RNA polymerase (VP1) JIP_LZII PF16471.5 EGD97496.1 - 0.1 12.8 0.1 0.19 12.0 0.1 1.4 1 0 0 1 1 1 0 JNK-interacting protein leucine zipper II PARM PF17061.5 EGD97496.1 - 0.2 11.8 0.1 0.2 11.8 0.1 2.4 2 1 1 3 3 3 0 PARM AMPK1_CBM PF16561.5 EGD97497.1 - 1.8e-07 31.2 0.1 4.7e-07 29.9 0.1 1.7 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase DUF1349 PF07081.11 EGD97498.1 - 1.6e-22 80.1 0.0 3e-22 79.2 0.0 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF1349) Cript PF10235.9 EGD97499.1 - 4.5e-24 84.8 9.9 4.5e-24 84.8 9.9 1.9 1 1 1 2 2 2 1 Microtubule-associated protein CRIPT DZR PF12773.7 EGD97499.1 - 0.0042 17.1 15.0 0.41 10.7 10.3 3.0 1 1 1 2 2 2 2 Double zinc ribbon zinc_ribbon_15 PF17032.5 EGD97499.1 - 0.018 15.8 12.8 0.051 14.3 9.6 2.7 2 1 0 2 2 2 0 zinc-ribbon family zinc_ribbon_2 PF13240.6 EGD97499.1 - 0.29 10.9 8.7 9.5 6.1 0.8 3.4 2 1 2 4 4 4 0 zinc-ribbon domain CEBP_ZZ PF16366.5 EGD97499.1 - 0.39 11.0 8.1 0.25 11.6 4.7 2.0 2 0 0 2 2 2 0 Cytoplasmic polyadenylation element-binding protein ZZ domain LIM PF00412.22 EGD97499.1 - 2.1 8.7 11.3 2.2 8.6 0.1 3.5 3 1 0 3 3 3 0 LIM domain DUF1272 PF06906.11 EGD97499.1 - 2.2 8.4 8.7 0.67 10.1 4.4 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1272) DUF2039 PF10217.9 EGD97499.1 - 4 7.8 17.5 2.7 8.4 11.5 2.6 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2039) MRP-L46 PF11788.8 EGD97500.1 - 2.4e-38 131.5 0.2 3.7e-38 130.9 0.2 1.3 1 0 0 1 1 1 1 39S mitochondrial ribosomal protein L46 TFIIF_alpha PF05793.12 EGD97501.1 - 0.0017 17.0 16.5 0.0026 16.4 16.5 1.2 1 0 0 1 1 1 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) SRP-alpha_N PF04086.13 EGD97501.1 - 0.067 13.1 20.6 0.12 12.2 20.6 1.3 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal CDC45 PF02724.14 EGD97501.1 - 0.1 10.9 13.6 0.15 10.3 13.6 1.3 1 0 0 1 1 1 0 CDC45-like protein Borrelia_P83 PF05262.11 EGD97501.1 - 1.4 7.3 16.4 2 6.8 16.4 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein Folliculin PF11704.8 EGD97501.1 - 2.4 8.0 8.7 6.6 6.6 8.7 1.8 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport RR_TM4-6 PF06459.12 EGD97501.1 - 3.9 7.2 22.3 2.1 8.1 20.1 1.6 1 1 0 1 1 1 0 Ryanodine Receptor TM 4-6 SAPS PF04499.15 EGD97501.1 - 5 5.8 13.3 7.7 5.2 13.3 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein FAM178 PF14816.6 EGD97501.1 - 5.4 5.9 15.2 13 4.6 15.2 1.6 1 0 0 1 1 1 0 Family of unknown function, FAM178 Suf PF05843.14 EGD97501.1 - 7.3 6.5 15.6 0.32 10.9 10.0 1.5 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) ALMT PF11744.8 EGD97501.1 - 7.5 5.3 10.2 12 4.6 10.2 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter CAF1 PF04857.20 EGD97502.1 - 2.3e-84 283.3 0.0 2.9e-84 283.0 0.0 1.1 1 0 0 1 1 1 1 CAF1 family ribonuclease HDA2-3 PF11496.8 EGD97502.1 - 0.073 12.2 0.0 0.16 11.1 0.0 1.6 1 0 0 1 1 1 0 Class II histone deacetylase complex subunits 2 and 3 DNA_pol_A_exo1 PF01612.20 EGD97502.1 - 0.098 12.4 0.0 0.67 9.6 0.0 2.3 2 0 0 2 2 2 0 3'-5' exonuclease Mito_carr PF00153.27 EGD97503.1 - 1.5e-66 220.3 1.2 2.3e-22 78.7 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Cofilin_ADF PF00241.20 EGD97504.1 - 4.6e-29 100.7 0.0 7e-16 58.1 0.0 2.1 2 0 0 2 2 2 2 Cofilin/tropomyosin-type actin-binding protein PHF5 PF03660.14 EGD97505.1 - 4.3e-52 174.7 9.5 4.9e-52 174.5 9.5 1.0 1 0 0 1 1 1 1 PHF5-like protein PolC_DP2 PF03833.13 EGD97505.1 - 0.6 7.9 7.2 0.63 7.8 7.2 1.2 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 DZR PF12773.7 EGD97505.1 - 1.9 8.6 15.3 2.3 8.3 1.1 3.0 1 1 1 2 2 2 0 Double zinc ribbon Pkinase PF00069.25 EGD97506.1 - 6.9e-23 81.4 0.0 3.2e-22 79.2 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD97506.1 - 2.9e-11 43.2 0.0 6.1e-11 42.1 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EGD97506.1 - 7.6e-06 24.9 0.6 1.2e-05 24.3 0.6 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EGD97506.1 - 0.0074 16.2 0.0 0.011 15.7 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 EGD97506.1 - 0.013 14.9 0.0 0.02 14.2 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Antimicrobial15 PF08110.12 EGD97506.1 - 0.1 12.9 0.5 0.24 11.7 0.0 1.8 2 0 0 2 2 2 0 Ocellatin family ketoacyl-synt PF00109.26 EGD97507.1 - 2.6e-72 243.4 0.0 4.4e-72 242.7 0.0 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain HTH_51 PF18558.1 EGD97507.1 - 2.8e-34 116.9 0.6 7.5e-34 115.5 0.4 1.9 2 0 0 2 2 1 1 Helix-turn-helix domain Ketoacyl-synt_C PF02801.22 EGD97507.1 - 2.5e-32 111.4 0.0 5.4e-32 110.3 0.0 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Acyl_transf_1 PF00698.21 EGD97507.1 - 2e-25 90.0 0.0 4.1e-25 88.9 0.0 1.5 1 0 0 1 1 1 1 Acyl transferase domain NAD_binding_4 PF07993.12 EGD97507.1 - 7.4e-21 74.5 0.0 1.7e-20 73.3 0.0 1.7 1 0 0 1 1 1 1 Male sterility protein SAT PF16073.5 EGD97507.1 - 4.3e-19 69.2 0.0 2.1e-12 47.3 0.0 2.6 2 0 0 2 2 2 2 Starter unit:ACP transacylase in aflatoxin biosynthesis Methyltransf_12 PF08242.12 EGD97507.1 - 1.3e-13 51.5 0.0 3.2e-13 50.2 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EGD97507.1 - 6.3e-11 42.8 0.1 2.3e-10 41.1 0.0 2.1 2 0 0 2 2 1 1 Methyltransferase domain PP-binding PF00550.25 EGD97507.1 - 9.1e-10 38.8 0.3 2.6e-09 37.3 0.3 1.9 1 0 0 1 1 1 1 Phosphopantetheine attachment site Methyltransf_31 PF13847.6 EGD97507.1 - 1.1e-09 38.3 0.0 2.8e-09 36.9 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EGD97507.1 - 4.3e-09 36.9 0.0 1.2e-08 35.5 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EGD97507.1 - 8.8e-09 35.4 0.0 3.9e-08 33.3 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Thiolase_N PF00108.23 EGD97507.1 - 2.7e-07 30.2 0.3 2.8e-05 23.6 0.1 2.4 2 0 0 2 2 2 1 Thiolase, N-terminal domain Epimerase PF01370.21 EGD97507.1 - 6.1e-06 25.9 0.0 1.4e-05 24.7 0.0 1.6 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Ubie_methyltran PF01209.18 EGD97507.1 - 1.3e-05 24.7 0.0 0.00058 19.3 0.0 3.3 4 0 0 4 4 4 1 ubiE/COQ5 methyltransferase family KAsynt_C_assoc PF16197.5 EGD97507.1 - 0.00032 21.1 0.0 0.00079 19.9 0.0 1.7 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Polysacc_synt_2 PF02719.15 EGD97507.1 - 0.0017 17.6 0.0 0.032 13.4 0.0 2.2 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein Methyltransf_32 PF13679.6 EGD97507.1 - 0.038 14.0 0.0 0.083 12.9 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain NodS PF05401.11 EGD97507.1 - 0.081 12.5 0.0 0.17 11.4 0.0 1.5 1 0 0 1 1 1 0 Nodulation protein S (NodS) RmlD_sub_bind PF04321.17 EGD97507.1 - 0.13 11.4 0.0 12 4.9 0.0 2.8 3 0 0 3 3 3 0 RmlD substrate binding domain KR PF08659.10 EGD97507.1 - 0.13 12.2 0.0 0.32 10.9 0.0 1.7 1 0 0 1 1 1 0 KR domain DXP_reductoisom PF02670.16 EGD97507.1 - 0.15 12.8 0.4 0.43 11.3 0.1 2.0 2 0 0 2 2 1 0 1-deoxy-D-xylulose 5-phosphate reductoisomerase p450 PF00067.22 EGD97508.1 - 2.6e-56 191.3 0.0 3.3e-56 191.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 MFS_1 PF07690.16 EGD97509.1 - 2.4e-37 128.7 49.6 1.3e-36 126.2 49.6 2.1 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 EGD97509.1 - 6.9e-12 44.6 10.4 1.1e-11 44.0 10.4 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) DUF4728 PF15860.5 EGD97509.1 - 2.6 8.8 8.8 0.97 10.2 0.5 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4728) Myb_DNA-bind_6 PF13921.6 EGD97510.1 - 2.6e-25 88.4 9.6 2.5e-13 50.1 0.9 3.8 1 1 2 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 EGD97510.1 - 1.9e-24 85.5 18.6 4.5e-11 42.8 0.6 4.1 4 0 0 4 4 4 3 Myb-like DNA-binding domain Rap1_C PF11626.8 EGD97510.1 - 0.024 14.7 4.0 15 5.7 0.4 3.5 2 1 1 3 3 3 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain SLIDE PF09111.10 EGD97510.1 - 0.034 14.2 0.0 0.39 10.8 0.0 2.5 2 1 1 3 3 3 0 SLIDE MADF_DNA_bdg PF10545.9 EGD97510.1 - 0.13 12.6 7.3 1.9 8.8 0.1 4.1 3 2 0 3 3 3 0 Alcohol dehydrogenase transcription factor Myb/SANT-like DIOX_N PF14226.6 EGD97511.1 - 5.1e-30 104.7 0.0 8e-30 104.0 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EGD97511.1 - 4.4e-20 72.1 0.0 9.6e-20 71.0 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DUF2141 PF09912.9 EGD97511.1 - 0.00087 19.2 0.0 0.0016 18.3 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2141) Pinin_SDK_memA PF04696.13 EGD97512.1 - 6.1e-32 110.4 4.9 6.1e-32 110.4 4.9 1.7 1 1 0 1 1 1 1 pinin/SDK/memA/ protein conserved region Abhydrolase_1 PF00561.20 EGD97513.1 - 1.2e-05 25.2 0.0 1.9e-05 24.4 0.0 1.3 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EGD97513.1 - 0.021 15.4 0.0 0.025 15.2 0.0 1.1 1 0 0 1 1 1 0 Alpha/beta hydrolase family Sacchrp_dh_NADP PF03435.18 EGD97514.1 - 2.8e-17 63.2 0.0 5.3e-17 62.3 0.0 1.5 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Semialdhyde_dh PF01118.24 EGD97514.1 - 0.011 16.2 0.0 0.08 13.4 0.0 2.2 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain FIT1_2 PF17357.2 EGD97514.1 - 0.14 12.3 0.1 0.32 11.1 0.1 1.5 1 0 0 1 1 1 0 Facilitor Of iron transport 1 and 2 Ribosomal_L37ae PF01780.19 EGD97515.1 - 4.3e-40 135.7 11.9 4.8e-40 135.5 11.9 1.0 1 0 0 1 1 1 1 Ribosomal L37ae protein family zf-RING_13 PF17977.1 EGD97515.1 - 0.00032 20.8 1.6 0.00043 20.4 1.6 1.2 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain Zn_Tnp_IS1595 PF12760.7 EGD97515.1 - 0.0031 17.4 2.8 0.0052 16.7 2.8 1.4 1 0 0 1 1 1 1 Transposase zinc-ribbon domain DUF1451 PF07295.11 EGD97515.1 - 0.014 15.4 0.5 0.02 14.9 0.5 1.2 1 0 0 1 1 1 0 Zinc-ribbon containing domain zf-BED PF02892.15 EGD97515.1 - 0.028 14.4 4.6 1.2 9.2 0.5 2.2 1 1 1 2 2 2 0 BED zinc finger PHD PF00628.29 EGD97516.1 - 3.1e-09 36.6 8.4 3.1e-09 36.6 8.4 2.6 2 0 0 2 2 2 1 PHD-finger zf-RING_2 PF13639.6 EGD97516.1 - 1.4e-08 34.9 1.5 1.4e-08 34.9 1.5 3.4 3 0 0 3 3 3 1 Ring finger domain zf-rbx1 PF12678.7 EGD97516.1 - 8.9e-07 29.1 1.2 8.9e-07 29.1 1.2 2.4 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 EGD97516.1 - 9.1e-06 25.4 2.0 9.1e-06 25.4 2.0 2.9 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EGD97516.1 - 1.6e-05 24.7 3.4 1.6e-05 24.7 3.4 2.9 2 2 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) PHD_2 PF13831.6 EGD97516.1 - 1.7e-05 24.2 3.9 4.1e-05 23.0 3.9 1.7 1 0 0 1 1 1 1 PHD-finger zf-RING_5 PF14634.6 EGD97516.1 - 3.6e-05 23.6 2.1 3.6e-05 23.6 2.1 2.5 2 2 0 2 2 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 EGD97516.1 - 5e-05 23.1 1.5 5e-05 23.1 1.5 2.6 2 1 0 2 2 2 1 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 EGD97516.1 - 7.9e-05 22.4 1.0 7.9e-05 22.4 1.0 3.1 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 EGD97516.1 - 0.00048 20.1 0.3 0.00048 20.1 0.3 1.9 2 0 0 2 2 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.6 EGD97516.1 - 0.0052 16.8 2.6 0.0052 16.8 2.6 3.8 2 2 1 3 3 2 1 RING-type zinc-finger zinc_ribbon_16 PF17034.5 EGD97516.1 - 0.031 14.5 0.3 0.065 13.4 0.3 1.5 1 0 0 1 1 1 0 Zinc-ribbon like family zf-PHD-like PF15446.6 EGD97516.1 - 0.19 11.3 5.3 0.073 12.7 2.0 2.1 2 0 0 2 2 2 0 PHD/FYVE-zinc-finger like domain zf-RING_4 PF14570.6 EGD97516.1 - 0.7 9.7 6.3 0.15 11.8 1.1 2.4 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain zf-RING-like PF08746.11 EGD97516.1 - 4.5 7.7 9.2 2.8 8.3 1.7 2.6 2 0 0 2 2 2 0 RING-like domain Zn_ribbon_17 PF17120.5 EGD97516.1 - 6.7 6.4 9.9 0.4 10.4 1.5 2.4 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type DUF1644 PF07800.12 EGD97516.1 - 6.9 6.7 7.8 12 5.9 4.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1644) Ank_5 PF13857.6 EGD97517.1 - 5.6e-10 39.3 0.3 5.4e-08 33.0 0.0 2.0 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 EGD97517.1 - 1.4e-09 38.0 0.1 1.2e-07 31.8 0.0 2.9 3 0 0 3 3 3 1 Ankyrin repeat Ank_3 PF13606.6 EGD97517.1 - 1.4e-08 34.3 0.0 8e-07 28.9 0.0 2.8 3 0 0 3 3 3 1 Ankyrin repeat Ank_2 PF12796.7 EGD97517.1 - 2.4e-07 31.2 0.0 4.1e-07 30.5 0.0 1.5 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EGD97517.1 - 2.9e-05 24.5 0.0 6.4e-05 23.4 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_5 PF13857.6 EGD97518.1 - 8.6e-18 64.2 1.0 3.3e-07 30.4 0.0 4.0 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 EGD97518.1 - 8.7e-14 51.7 0.2 6.4e-07 29.8 0.0 3.3 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EGD97518.1 - 3.4e-11 42.3 1.1 0.098 13.3 0.0 5.2 5 0 0 5 5 5 3 Ankyrin repeat Ank_2 PF12796.7 EGD97518.1 - 6.5e-11 42.7 0.1 2.9e-06 27.8 0.1 2.9 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 EGD97518.1 - 1.3e-07 31.7 0.1 0.054 14.0 0.0 4.1 4 0 0 4 4 4 2 Ankyrin repeat Phlebovirus_G1 PF07243.11 EGD97518.1 - 0.0058 15.1 0.0 0.0074 14.7 0.0 1.1 1 0 0 1 1 1 1 Phlebovirus glycoprotein G1 UDPG_MGDP_dh_C PF03720.15 EGD97518.1 - 0.047 14.1 0.1 0.5 10.8 0.1 2.3 2 1 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain MFS_1 PF07690.16 EGD97519.1 - 5.2e-38 130.9 34.6 5.2e-38 130.9 34.6 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EGD97519.1 - 3e-05 23.1 11.8 3e-05 23.1 11.8 2.9 3 1 0 3 3 3 1 Sugar (and other) transporter ATP-synt_8 PF00895.20 EGD97519.1 - 6.8 7.2 7.3 1.9 9.0 2.0 2.8 2 0 0 2 2 2 0 ATP synthase protein 8 HEAT_2 PF13646.6 EGD97520.1 - 6.4e-08 32.9 3.1 1.3e-06 28.7 0.9 3.5 2 1 1 3 3 3 2 HEAT repeats HEAT PF02985.22 EGD97520.1 - 1.3e-05 25.0 8.2 0.18 12.1 0.1 5.5 5 0 0 5 5 5 2 HEAT repeat Cnd1 PF12717.7 EGD97520.1 - 2e-05 24.7 0.4 0.0027 17.8 0.1 4.3 4 1 1 5 5 5 2 non-SMC mitotic condensation complex subunit 1 CLASP_N PF12348.8 EGD97520.1 - 0.038 13.6 0.0 1.6 8.2 0.0 2.9 1 1 1 2 2 2 0 CLASP N terminal DUF3734 PF12536.8 EGD97520.1 - 0.046 14.1 0.2 0.9 9.9 0.0 3.1 2 0 0 2 2 2 0 Patatin phospholipase HEAT_EZ PF13513.6 EGD97520.1 - 0.062 13.8 11.6 0.093 13.3 0.3 5.1 6 0 0 6 6 6 0 HEAT-like repeat DUF4299 PF14132.6 EGD97520.1 - 0.12 11.8 0.1 0.36 10.2 0.1 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4299) Arena_ncap_C PF17290.2 EGD97520.1 - 0.13 11.6 0.0 0.32 10.3 0.0 1.6 1 0 0 1 1 1 0 Arenavirus nucleocapsid C-terminal domain SNF5 PF04855.12 EGD97521.1 - 5.6e-64 216.2 0.0 1.1e-62 212.0 0.0 2.3 1 1 0 1 1 1 1 SNF5 / SMARCB1 / INI1 INO80_Ies4 PF08193.11 EGD97521.1 - 0.00017 21.7 1.9 0.00017 21.7 1.9 3.6 4 1 1 5 5 5 1 INO80 complex subunit Ies4 Exo_endo_phos PF03372.23 EGD97522.1 - 1e-06 28.4 0.0 1.5e-06 27.9 0.0 1.3 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Peptidase_M24 PF00557.24 EGD97523.1 - 7.9e-09 35.5 0.0 1e-08 35.2 0.0 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 S-antigen PF05756.11 EGD97523.1 - 0.059 13.7 2.4 0.15 12.5 2.4 1.7 1 0 0 1 1 1 0 S-antigen protein PBP1_TM PF14812.6 EGD97523.1 - 2.2 8.7 6.7 4.9 7.6 6.7 1.6 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal PHD PF00628.29 EGD97524.1 - 1e-17 63.7 16.6 2.5e-11 43.3 6.6 2.4 2 0 0 2 2 2 2 PHD-finger zf-PHD-like PF15446.6 EGD97524.1 - 0.15 11.7 12.2 0.48 10.0 2.7 3.1 3 0 0 3 3 3 0 PHD/FYVE-zinc-finger like domain zf-HC5HC2H PF13771.6 EGD97524.1 - 0.46 10.8 4.5 1.8 8.9 1.1 2.5 2 0 0 2 2 2 0 PHD-like zinc-binding domain PHD_2 PF13831.6 EGD97524.1 - 1 9.0 8.9 0.76 9.4 1.2 3.2 3 0 0 3 3 3 0 PHD-finger C1_1 PF00130.22 EGD97524.1 - 6.6 6.7 6.5 23 5.0 1.5 2.5 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Lectin_leg-like PF03388.13 EGD97525.1 - 9.5e-25 87.3 0.0 1.3e-24 86.8 0.0 1.2 1 0 0 1 1 1 1 Legume-like lectin family Dynamitin PF04912.14 EGD97525.1 - 0.0092 15.3 1.7 0.012 14.9 1.7 1.1 1 0 0 1 1 1 1 Dynamitin TMF_TATA_bd PF12325.8 EGD97525.1 - 0.011 16.0 3.0 0.017 15.3 3.0 1.3 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding DUF4349 PF14257.6 EGD97525.1 - 0.015 14.8 0.1 0.023 14.1 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4349) ALMT PF11744.8 EGD97525.1 - 0.027 13.3 0.7 0.04 12.8 0.7 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Sperm_Ag_HE2 PF05324.13 EGD97525.1 - 0.061 13.8 0.0 9.5 6.8 0.0 2.5 2 0 0 2 2 2 0 Sperm antigen HE2 WXG100 PF06013.12 EGD97525.1 - 0.11 12.7 0.2 1.8 8.8 0.0 2.4 2 0 0 2 2 2 0 Proteins of 100 residues with WXG FUSC PF04632.12 EGD97525.1 - 0.26 9.8 0.6 0.35 9.4 0.6 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family DUF5385 PF17359.2 EGD97525.1 - 1.1 8.8 3.1 0.86 9.1 0.5 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5385) YlbD_coat PF14071.6 EGD97525.1 - 1.8 8.8 5.2 2.8 8.2 0.9 2.2 1 1 1 2 2 2 0 Putative coat protein APG6_N PF17675.1 EGD97525.1 - 2 9.0 4.1 5.1 7.6 4.1 1.7 1 1 0 1 1 1 0 Apg6 coiled-coil region Alg6_Alg8 PF03155.15 EGD97526.1 - 2.8e-173 577.4 26.3 3.2e-173 577.1 26.3 1.0 1 0 0 1 1 1 1 ALG6, ALG8 glycosyltransferase family WAC_Acf1_DNA_bd PF10537.9 EGD97527.1 - 1.5e-23 83.2 0.5 5.6e-23 81.4 0.1 2.2 2 0 0 2 2 2 1 ATP-utilising chromatin assembly and remodelling N-terminal WSD PF15613.6 EGD97527.1 - 4.4e-23 81.6 0.5 4.4e-23 81.6 0.5 3.4 3 1 0 3 3 3 1 Williams-Beuren syndrome DDT (WSD), D-TOX E motif DDT PF02791.17 EGD97527.1 - 3.7e-17 62.4 1.5 7.2e-17 61.5 1.5 1.4 1 0 0 1 1 1 1 DDT domain WHIM1 PF15612.6 EGD97527.1 - 5.1e-10 38.6 0.0 1.3e-09 37.4 0.0 1.7 1 0 0 1 1 1 1 WSTF, HB1, Itc1p, MBD9 motif 1 CtIP_N PF10482.9 EGD97527.1 - 6.2 6.9 13.8 2.2 8.3 1.1 3.4 2 1 1 3 3 3 0 Tumour-suppressor protein CtIP N-terminal domain Mito_carr PF00153.27 EGD97528.1 - 8.6e-60 198.7 3.4 1.7e-21 75.9 0.1 4.0 3 1 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 EGD97528.1 - 0.026 13.7 0.0 2.8 7.0 0.0 2.4 2 0 0 2 2 2 0 Gammaproteobacterial serine protease Pex2_Pex12 PF04757.14 EGD97529.1 - 1.9e-54 184.6 2.4 2.6e-54 184.2 2.4 1.2 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-C3HC4_4 PF15227.6 EGD97529.1 - 5.1e-06 26.5 2.8 9.2e-06 25.7 2.8 1.4 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.6 EGD97529.1 - 0.00066 20.0 1.1 0.0014 19.0 1.1 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EGD97529.1 - 0.00074 19.3 1.8 0.0014 18.4 1.0 1.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EGD97529.1 - 0.002 18.1 2.4 0.002 18.1 2.4 1.9 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 EGD97529.1 - 0.0022 17.8 1.1 0.0043 16.9 1.1 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EGD97529.1 - 0.0033 17.2 1.4 0.0064 16.3 1.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Auto_anti-p27 PF06677.12 EGD97529.1 - 3.4 7.9 4.8 6.5 7.0 4.8 1.4 1 0 0 1 1 1 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) RsfS PF02410.15 EGD97530.1 - 4.4e-11 43.1 0.0 1e-10 41.9 0.0 1.7 1 0 0 1 1 1 1 Ribosomal silencing factor during starvation NMD3 PF04981.13 EGD97531.1 - 8.2e-80 267.8 4.1 1.5e-79 266.9 4.1 1.4 1 0 0 1 1 1 1 NMD3 family HypA PF01155.19 EGD97531.1 - 0.45 10.6 9.6 2.1 8.4 1.3 3.1 2 1 1 3 3 3 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Rhodanese_C PF12368.8 EGD97531.1 - 9.4 6.7 9.5 5.2 7.5 6.3 2.0 2 0 0 2 2 2 0 Rhodanase C-terminal RRM_1 PF00076.22 EGD97532.1 - 0.0021 17.8 0.0 1.2 9.0 0.0 2.8 1 1 1 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Glyco_hydro_125 PF06824.11 EGD97533.1 - 5.7e-180 598.6 0.0 6.6e-180 598.4 0.0 1.0 1 0 0 1 1 1 1 Metal-independent alpha-mannosidase (GH125) CDC27 PF09507.10 EGD97534.1 - 6.8e-86 289.3 26.1 8e-86 289.1 26.1 1.0 1 0 0 1 1 1 1 DNA polymerase subunit Cdc27 zf-C3HC4_2 PF13923.6 EGD97535.1 - 3.1e-10 39.7 22.2 1e-09 38.0 15.9 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EGD97535.1 - 3.4e-07 30.0 13.2 3.4e-07 30.0 13.2 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.6 EGD97535.1 - 1e-06 28.5 7.8 1e-06 28.5 7.8 1.7 2 0 0 2 2 2 1 zf-RING of BARD1-type protein zf-C3HC4 PF00097.25 EGD97535.1 - 2.4e-06 27.3 17.0 2.4e-06 27.3 17.0 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EGD97535.1 - 1.2e-05 25.2 16.4 1.2e-05 25.2 16.4 2.3 2 0 0 2 2 2 1 zinc-RING finger domain SAP PF02037.27 EGD97535.1 - 1.3e-05 24.8 0.0 3e-05 23.6 0.0 1.6 1 0 0 1 1 1 1 SAP domain zf-RING_2 PF13639.6 EGD97535.1 - 2e-05 24.8 22.1 4.1e-05 23.8 17.0 2.3 2 0 0 2 2 2 1 Ring finger domain zf-RING_UBOX PF13445.6 EGD97535.1 - 0.00013 22.0 22.3 0.00013 22.0 16.9 2.5 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 EGD97535.1 - 0.00048 20.2 20.4 0.00073 19.6 17.0 2.3 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 EGD97535.1 - 0.00048 19.9 17.0 0.1 12.5 15.0 2.3 2 0 0 2 2 2 2 Prokaryotic RING finger family 4 U-box PF04564.15 EGD97535.1 - 0.02 15.1 0.0 0.076 13.2 0.0 2.0 2 0 0 2 2 1 0 U-box domain Mob_synth_C PF06463.13 EGD97535.1 - 0.031 14.2 5.3 0.066 13.1 5.3 1.5 1 0 0 1 1 1 0 Molybdenum Cofactor Synthesis C Rad50_zn_hook PF04423.14 EGD97535.1 - 0.14 12.0 3.6 5.9 6.8 1.4 2.7 2 0 0 2 2 2 0 Rad50 zinc hook motif zf-ANAPC11 PF12861.7 EGD97535.1 - 0.19 11.8 5.2 0.49 10.5 5.2 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.7 EGD97535.1 - 0.44 10.9 16.9 0.065 13.5 11.8 2.2 2 1 0 2 2 2 0 RING-H2 zinc finger domain zf-WRNIP1_ubi PF18279.1 EGD97535.1 - 1.8 9.3 5.2 3.7 8.4 0.2 2.8 3 0 0 3 3 2 0 Werner helicase-interacting protein 1 ubiquitin-binding domain zf-RING_10 PF16685.5 EGD97535.1 - 5.9 7.1 13.8 0.32 11.2 8.1 1.8 2 0 0 2 2 2 0 zinc RING finger of MSL2 Snf7 PF03357.21 EGD97536.1 - 9.8e-17 61.1 11.8 9.8e-17 61.1 11.8 2.2 1 1 1 2 2 2 1 Snf7 PspA_IM30 PF04012.12 EGD97536.1 - 0.27 10.8 19.4 1.5 8.4 17.6 2.5 1 1 0 1 1 1 0 PspA/IM30 family DUF948 PF06103.11 EGD97536.1 - 0.86 9.9 12.9 38 4.6 6.5 3.7 2 2 0 2 2 2 0 Bacterial protein of unknown function (DUF948) LPP PF04728.13 EGD97536.1 - 1 9.8 4.7 0.62 10.5 0.2 3.0 3 0 0 3 3 3 0 Lipoprotein leucine-zipper TRAPPC-Trs85 PF12739.7 EGD97539.1 - 2e-110 369.6 0.0 1.5e-108 363.4 0.0 2.0 2 0 0 2 2 2 2 ER-Golgi trafficking TRAPP I complex 85 kDa subunit PolyA_pol PF01743.20 EGD97540.1 - 6.4e-24 84.8 0.1 1.8e-23 83.3 0.1 1.8 1 1 0 1 1 1 1 Poly A polymerase head domain PolyA_pol_RNAbd PF12627.7 EGD97540.1 - 3.1e-07 30.1 0.0 7.6e-07 28.8 0.0 1.7 1 0 0 1 1 1 1 Probable RNA and SrmB- binding site of polymerase A tRNA_NucTran2_2 PF13735.6 EGD97540.1 - 0.00014 21.9 0.0 0.00024 21.1 0.0 1.3 1 0 0 1 1 1 1 tRNA nucleotidyltransferase domain 2 putative CdiI_2 PF18593.1 EGD97540.1 - 0.13 13.0 0.0 0.79 10.4 0.0 2.3 2 0 0 2 2 2 0 CdiI immunity protein Tti2 PF10521.9 EGD97541.1 - 3.2e-89 299.2 2.1 1.5e-88 297.1 1.0 2.0 2 0 0 2 2 2 1 Tti2 family Syja_N PF02383.18 EGD97542.1 - 2.4e-77 260.4 0.0 4e-77 259.7 0.0 1.4 1 0 0 1 1 1 1 SacI homology domain LIP PF03583.14 EGD97543.1 - 3.1e-79 266.3 0.0 4e-79 265.9 0.0 1.1 1 0 0 1 1 1 1 Secretory lipase Glyco_hydro_47 PF01532.20 EGD97544.1 - 2.4e-182 607.0 0.0 2.8e-182 606.7 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 TAtT PF16811.5 EGD97544.1 - 0.15 11.3 0.1 0.6 9.3 0.0 1.8 2 0 0 2 2 2 0 TRAP transporter T-component IBV_3C PF03620.13 EGD97545.1 - 0.02 15.4 0.5 0.052 14.0 0.1 1.9 2 0 0 2 2 2 0 IBV 3C protein DUF1772 PF08592.11 EGD97545.1 - 0.026 14.8 4.1 0.039 14.3 2.7 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF1772) Pkinase PF00069.25 EGD97546.1 - 3.2e-31 108.7 0.0 1.2e-16 60.9 0.0 2.5 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EGD97546.1 - 1.6e-11 44.0 0.0 6.6e-05 22.3 0.0 2.6 2 1 0 2 2 2 2 Protein tyrosine kinase Fungal_trans_2 PF11951.8 EGD97547.1 - 5.5e-10 38.6 1.1 7.5e-09 34.9 0.5 2.2 2 0 0 2 2 2 2 Fungal specific transcription factor domain Zn_clus PF00172.18 EGD97547.1 - 7e-08 32.5 9.9 1.2e-07 31.7 9.9 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DNA_pol_B PF00136.21 EGD97548.1 - 9.4e-132 440.0 8.4 1.4e-124 416.3 5.4 2.2 1 1 1 2 2 2 2 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 EGD97548.1 - 8.6e-80 268.4 0.2 1.9e-79 267.2 0.0 1.7 2 0 0 2 2 2 1 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.6 EGD97548.1 - 1.9e-19 69.9 3.1 4.5e-19 68.7 3.1 1.7 1 0 0 1 1 1 1 C4-type zinc-finger of DNA polymerase delta RNase_H_2 PF13482.6 EGD97548.1 - 0.00047 20.2 0.2 0.0025 17.8 0.2 2.2 1 1 0 1 1 1 1 RNase_H superfamily DNA_pol_B_exo2 PF10108.9 EGD97548.1 - 0.0083 15.8 0.1 0.02 14.6 0.1 1.6 1 0 0 1 1 1 1 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB C1_1 PF00130.22 EGD97548.1 - 0.017 15.0 6.7 0.072 13.0 1.0 2.6 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) ETC_C1_NDUFA5 PF04716.14 EGD97548.1 - 0.055 13.3 0.0 0.17 11.7 0.0 1.9 1 0 0 1 1 1 0 ETC complex I subunit conserved region FAD_binding_3 PF01494.19 EGD97549.1 - 1.6e-15 57.2 0.0 3.7e-11 42.9 0.0 2.2 2 0 0 2 2 2 2 FAD binding domain DAO PF01266.24 EGD97549.1 - 2.9e-05 23.8 0.0 0.00017 21.3 0.0 2.2 3 0 0 3 3 3 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EGD97549.1 - 0.00027 21.1 0.0 0.00065 19.9 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EGD97549.1 - 0.0006 19.1 0.0 0.001 18.4 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EGD97549.1 - 0.00071 19.0 0.1 0.0052 16.2 0.1 1.9 2 0 0 2 2 2 1 FAD dependent oxidoreductase GIDA PF01134.22 EGD97549.1 - 0.0011 18.2 0.0 0.0025 17.0 0.0 1.7 2 0 0 2 2 2 1 Glucose inhibited division protein A HI0933_like PF03486.14 EGD97549.1 - 0.0016 17.3 0.0 0.0046 15.7 0.0 1.7 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox PF00070.27 EGD97549.1 - 0.0073 16.9 0.0 0.014 16.0 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.18 EGD97549.1 - 0.046 13.6 0.0 0.078 12.9 0.0 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain SE PF08491.10 EGD97549.1 - 0.057 12.5 0.0 0.17 10.9 0.0 1.7 1 1 0 1 1 1 0 Squalene epoxidase AlaDh_PNT_C PF01262.21 EGD97549.1 - 0.067 12.5 0.0 0.12 11.6 0.0 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain MFS_1 PF07690.16 EGD97550.1 - 9.6e-30 103.7 41.5 1.5e-27 96.5 34.6 2.6 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 EGD97550.1 - 0.00042 19.3 13.3 0.00042 19.3 13.3 2.3 2 1 0 2 2 2 1 MFS_1 like family DUF3043 PF11241.8 EGD97550.1 - 6.4 6.8 5.2 2.3 8.2 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3043) DUF349 PF03993.12 EGD97551.1 - 0.087 13.1 3.7 0.095 13.0 1.3 2.2 3 0 0 3 3 3 0 Domain of Unknown Function (DUF349) Ca_chan_IQ PF08763.11 EGD97553.1 - 0.06 13.6 0.1 0.16 12.2 0.1 1.8 1 1 0 1 1 1 0 Voltage gated calcium channel IQ domain pRN1_helical PF13010.6 EGD97553.1 - 0.1 12.6 0.6 0.27 11.2 0.6 1.8 1 1 0 1 1 1 0 Primase helical domain zf-C2H2_4 PF13894.6 EGD97554.1 - 1.1e-10 41.4 22.8 0.19 12.7 0.2 7.3 7 0 0 7 7 7 4 C2H2-type zinc finger zf-C2H2 PF00096.26 EGD97554.1 - 1.7e-06 28.1 24.7 0.079 13.5 0.1 6.0 7 0 0 7 7 6 3 Zinc finger, C2H2 type zf-met PF12874.7 EGD97554.1 - 5e-05 23.5 15.8 0.033 14.6 0.2 4.9 5 0 0 5 5 4 2 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EGD97554.1 - 0.00015 21.9 0.9 0.019 15.3 0.1 4.7 5 0 0 5 5 4 2 Zinc-finger double-stranded RNA-binding zf-C2H2_3rep PF18868.1 EGD97554.1 - 0.012 16.2 8.7 0.032 14.9 0.6 3.0 3 0 0 3 3 3 0 Zinc finger C2H2-type, 3 repeats Prok-RING_4 PF14447.6 EGD97554.1 - 0.052 13.4 3.2 3 7.8 1.7 3.0 2 1 0 2 2 2 0 Prokaryotic RING finger family 4 zf-CSL PF05207.13 EGD97554.1 - 0.12 12.2 7.8 0.29 10.9 0.2 2.7 2 1 0 2 2 2 0 CSL zinc finger FOXP-CC PF16159.5 EGD97554.1 - 0.84 10.3 11.9 1.9 9.2 0.4 3.9 3 2 1 4 4 4 0 FOXP coiled-coil domain zf-C3HC4_2 PF13923.6 EGD97554.1 - 1 9.3 8.7 4.4 7.2 0.9 3.7 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) zf-C2H2_9 PF16293.5 EGD97554.1 - 1.2 9.0 8.0 7.1 6.6 0.7 3.9 3 0 0 3 3 3 0 C2H2 type zinc-finger (1 copy) zf-C2H2_2 PF12756.7 EGD97554.1 - 1.5 9.2 22.6 3.4 8.1 2.8 5.1 2 2 2 5 5 5 0 C2H2 type zinc-finger (2 copies) Zn-ribbon_8 PF09723.10 EGD97554.1 - 3 8.0 11.1 0.7 10.1 1.1 3.6 2 1 1 3 3 3 0 Zinc ribbon domain Zn-C2H2_12 PF18112.1 EGD97554.1 - 3.9 8.0 7.9 11 6.6 0.3 3.7 3 0 0 3 3 3 0 Autophagy receptor zinc finger-C2H2 domain zf-C2H2_8 PF15909.5 EGD97554.1 - 4.8 7.6 9.4 1.3 9.4 1.8 2.8 2 1 0 2 2 2 0 C2H2-type zinc ribbon DZR PF12773.7 EGD97554.1 - 7.5 6.7 11.6 16 5.6 4.0 3.2 2 1 0 2 2 2 0 Double zinc ribbon zinc_ribbon_4 PF13717.6 EGD97554.1 - 7.6 6.5 10.2 23 5.0 1.4 3.8 3 1 0 3 3 3 0 zinc-ribbon domain Cyanate_lyase PF02560.14 EGD97555.1 - 5.4e-33 112.7 0.0 1.1e-32 111.7 0.0 1.5 2 0 0 2 2 2 1 Cyanate lyase C-terminal domain HTH_31 PF13560.6 EGD97555.1 - 0.00017 21.9 0.0 0.00027 21.2 0.0 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_26 PF13443.6 EGD97555.1 - 0.00077 19.9 0.0 0.0013 19.2 0.0 1.3 1 0 0 1 1 1 1 Cro/C1-type HTH DNA-binding domain HTH_3 PF01381.22 EGD97555.1 - 0.018 15.1 0.0 0.026 14.6 0.0 1.3 1 0 0 1 1 1 0 Helix-turn-helix Sigma70_r1_1 PF03979.14 EGD97555.1 - 0.14 12.3 0.0 0.26 11.4 0.0 1.4 1 0 0 1 1 1 0 Sigma-70 factor, region 1.1 Myb_DNA-binding PF00249.31 EGD97555.1 - 0.16 12.2 0.0 52 4.1 0.0 3.1 3 0 0 3 3 3 0 Myb-like DNA-binding domain GFA PF04828.14 EGD97556.1 - 5.5e-20 71.5 0.3 8.5e-20 70.9 0.3 1.3 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme PLDc_2 PF13091.6 EGD97557.1 - 2.7e-16 59.7 0.0 2.7e-07 30.5 0.0 3.7 3 1 0 3 3 3 2 PLD-like domain PLDc PF00614.22 EGD97557.1 - 8.1e-14 51.1 0.6 2e-06 27.8 0.0 2.7 2 0 0 2 2 2 2 Phospholipase D Active site motif Regulator_TrmB PF11495.8 EGD97557.1 - 0.14 11.3 0.1 0.64 9.1 0.0 1.9 2 0 0 2 2 2 0 Archaeal transcriptional regulator TrmB DUF4834 PF16118.5 EGD97557.1 - 2.6 9.1 7.8 37 5.4 0.1 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) DUF883 PF05957.13 EGD97557.1 - 6.5 7.4 6.0 1.6 9.4 0.9 2.6 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF883) SPT_ssu-like PF11779.8 EGD97559.1 - 0.0042 16.7 3.0 0.0059 16.2 3.0 1.3 1 0 0 1 1 1 1 Small subunit of serine palmitoyltransferase-like Kinetochor_Ybp2 PF08568.10 EGD97560.1 - 5.5e-118 395.2 0.2 6.4e-118 394.9 0.2 1.0 1 0 0 1 1 1 1 Uncharacterised protein family, YAP/Alf4/glomulin GST_C_2 PF13410.6 EGD97561.1 - 3.3e-05 23.8 0.0 6.5e-05 22.9 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EGD97561.1 - 0.095 12.9 0.0 0.27 11.5 0.0 1.7 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Rhomboid PF01694.22 EGD97562.1 - 3.3e-33 114.8 7.8 3.3e-33 114.8 7.8 1.8 2 0 0 2 2 2 1 Rhomboid family DUF2177 PF09945.9 EGD97562.1 - 0.34 11.0 6.1 0.43 10.7 0.4 2.8 2 1 1 3 3 3 0 Predicted membrane protein (DUF2177) DUF4381 PF14316.6 EGD97562.1 - 8.3 6.6 6.7 1.6 9.0 2.6 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4381) DUF3439 PF11921.8 EGD97566.1 - 1 9.3 30.9 0.23 11.4 2.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) DUF3306 PF11748.8 EGD97566.1 - 5.2 8.0 11.3 2.8 8.8 1.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3306) DUF1681 PF07933.14 EGD97567.1 - 3.6e-51 172.8 0.0 6.7e-51 171.9 0.0 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF1681) Sporozoite_P67 PF05642.11 EGD97567.1 - 0.0014 16.9 4.5 0.0026 15.9 4.5 1.4 1 1 0 1 1 1 1 Sporozoite P67 surface antigen LAT PF15234.6 EGD97567.1 - 0.055 13.2 5.5 0.93 9.2 1.2 2.3 2 0 0 2 2 2 0 Linker for activation of T-cells Pox_Ag35 PF03286.14 EGD97567.1 - 0.14 11.9 7.1 2.3 8.0 0.4 2.1 2 0 0 2 2 2 0 Pox virus Ag35 surface protein FAM176 PF14851.6 EGD97567.1 - 0.2 11.3 7.8 1.1 8.9 1.9 2.2 2 0 0 2 2 2 0 FAM176 family Med13_C PF06333.12 EGD97567.1 - 0.22 10.7 6.2 0.8 8.9 0.5 2.1 2 0 0 2 2 2 0 Mediator complex subunit 13 C-terminal domain CPSF100_C PF13299.6 EGD97567.1 - 0.41 10.8 6.1 1.2 9.3 1.0 2.2 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal SR-25 PF10500.9 EGD97567.1 - 0.64 9.6 10.6 1.2 8.7 10.6 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein TT_ORF2 PF02957.15 EGD97567.1 - 1.3 9.9 5.4 0.89 10.5 0.7 2.1 2 0 0 2 2 2 0 TT viral ORF2 PAXIP1_C PF15364.6 EGD97567.1 - 3.6 7.9 15.5 0.88 9.9 5.3 2.3 2 0 0 2 2 2 0 PAXIP1-associated-protein-1 C term PTIP binding protein LIN37 PF15306.6 EGD97567.1 - 4.9 7.3 7.8 1.6 8.9 2.5 2.1 2 0 0 2 2 2 0 LIN37 TFIIF_alpha PF05793.12 EGD97567.1 - 5.2 5.5 12.0 0.72 8.4 5.2 2.0 2 0 0 2 2 2 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) IF-2B PF01008.17 EGD97568.1 - 6.5e-51 173.2 0.0 3.1e-50 171.0 0.0 1.8 1 1 0 1 1 1 1 Initiation factor 2 subunit family DeoRC PF00455.22 EGD97568.1 - 0.0087 16.0 0.0 0.8 9.6 0.0 2.3 2 0 0 2 2 2 2 DeoR C terminal sensor domain DHR10 PF18595.1 EGD97569.1 - 9.2e-31 106.3 17.0 9.2e-31 106.3 17.0 4.5 4 1 0 4 4 4 1 Designed helical repeat protein 10 domain Nuf2 PF03800.14 EGD97569.1 - 1.6e-30 106.0 0.1 7.3e-30 103.9 0.1 2.2 1 1 0 1 1 1 1 Nuf2 family Syntaxin-6_N PF09177.11 EGD97569.1 - 0.32 11.6 34.1 0.093 13.3 1.8 4.2 2 1 2 4 4 4 0 Syntaxin 6, N-terminal Spc7 PF08317.11 EGD97569.1 - 0.73 8.7 54.3 4.8 6.0 25.8 3.3 1 1 2 3 3 3 0 Spc7 kinetochore protein FlaC_arch PF05377.11 EGD97569.1 - 1.5 9.3 24.1 0.55 10.7 1.1 5.3 5 1 1 6 6 6 0 Flagella accessory protein C (FlaC) Leu_zip PF15294.6 EGD97569.1 - 4.3 6.8 44.8 0.13 11.7 19.8 3.0 1 1 2 3 3 3 0 Leucine zipper VSG_B PF13206.6 EGD97569.1 - 5.4 6.2 32.6 2.4 7.3 0.0 3.1 1 1 2 3 3 3 0 Trypanosomal VSG domain YvrJ PF12841.7 EGD97569.1 - 6 6.5 5.8 31 4.2 0.0 4.0 4 0 0 4 4 4 0 YvrJ protein family DUF1664 PF07889.12 EGD97569.1 - 9.3 6.3 28.9 5.8 7.0 1.0 3.8 2 2 1 4 4 4 0 Protein of unknown function (DUF1664) Nha1_C PF08619.10 EGD97570.1 - 0.00055 19.3 2.0 0.00065 19.0 2.0 1.1 1 0 0 1 1 1 1 Alkali metal cation/H+ antiporter Nha1 C terminus Eapp_C PF10238.9 EGD97570.1 - 0.0021 18.2 0.7 0.0024 17.9 0.7 1.2 1 0 0 1 1 1 1 E2F-associated phosphoprotein Pox_Ag35 PF03286.14 EGD97570.1 - 0.013 15.4 3.3 0.018 14.8 3.3 1.2 1 0 0 1 1 1 0 Pox virus Ag35 surface protein DUF2126 PF09899.9 EGD97570.1 - 0.013 13.6 0.5 0.018 13.2 0.5 1.1 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) RPA43_OB PF17875.1 EGD97570.1 - 0.02 15.5 0.7 0.031 14.9 0.7 1.3 1 0 0 1 1 1 0 RPA43 OB domain in RNA Pol I RXT2_N PF08595.11 EGD97570.1 - 0.061 13.4 5.6 0.12 12.4 5.6 1.5 1 0 0 1 1 1 0 RXT2-like, N-terminal Zip PF02535.22 EGD97570.1 - 0.074 12.3 0.6 0.077 12.2 0.6 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter DUF913 PF06025.12 EGD97570.1 - 0.11 11.5 0.5 0.15 11.1 0.5 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF4820 PF16091.5 EGD97570.1 - 0.11 11.8 4.1 0.17 11.3 4.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) Presenilin PF01080.17 EGD97570.1 - 0.14 10.9 0.8 0.15 10.8 0.8 1.1 1 0 0 1 1 1 0 Presenilin WPP PF13943.6 EGD97570.1 - 0.18 12.2 1.4 0.27 11.6 0.6 1.7 2 0 0 2 2 1 0 WPP domain DUF4746 PF15928.5 EGD97570.1 - 0.21 11.0 7.4 0.26 10.7 7.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) CDC45 PF02724.14 EGD97570.1 - 0.21 9.8 7.2 0.27 9.5 7.2 1.1 1 0 0 1 1 1 0 CDC45-like protein FAM176 PF14851.6 EGD97570.1 - 0.29 10.8 7.3 0.47 10.1 7.3 1.3 1 0 0 1 1 1 0 FAM176 family FYDLN_acid PF09538.10 EGD97570.1 - 0.32 11.7 8.1 0.53 11.0 8.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) Tfb4 PF03850.14 EGD97570.1 - 0.34 10.3 1.5 0.5 9.8 1.5 1.1 1 0 0 1 1 1 0 Transcription factor Tfb4 DUF551 PF04448.12 EGD97570.1 - 0.39 11.7 3.9 6.7 7.7 1.4 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF551) Nucleo_P87 PF07267.11 EGD97570.1 - 0.39 9.5 4.5 0.53 9.1 4.5 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 Ribosomal_60s PF00428.19 EGD97570.1 - 0.46 11.1 14.1 0.26 11.9 11.2 2.0 2 1 0 2 2 2 0 60s Acidic ribosomal protein ALMT PF11744.8 EGD97570.1 - 0.52 9.1 2.1 0.69 8.7 2.1 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF2457 PF10446.9 EGD97570.1 - 0.55 9.3 15.0 0.74 8.9 15.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) TRAP_alpha PF03896.16 EGD97570.1 - 0.62 9.2 5.2 0.89 8.7 5.2 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit RPN2_C PF18004.1 EGD97570.1 - 0.66 9.9 6.4 1.1 9.2 6.4 1.2 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Nop14 PF04147.12 EGD97570.1 - 0.66 8.1 10.6 0.98 7.5 10.6 1.2 1 0 0 1 1 1 0 Nop14-like family NOA36 PF06524.12 EGD97570.1 - 0.67 9.2 11.5 0.96 8.7 11.5 1.2 1 0 0 1 1 1 0 NOA36 protein DNA_pol_phi PF04931.13 EGD97570.1 - 0.95 7.5 11.9 1.2 7.1 11.9 1.1 1 0 0 1 1 1 0 DNA polymerase phi TFB6 PF17110.5 EGD97570.1 - 1.2 8.9 4.3 2 8.1 4.3 1.4 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH V_ATPase_I PF01496.19 EGD97570.1 - 3.4 5.5 5.3 4.2 5.1 5.3 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Astro_capsid_p PF12226.8 EGD97570.1 - 3.6 6.7 9.8 4.6 6.3 9.8 1.1 1 0 0 1 1 1 0 Turkey astrovirus capsid protein Cytomega_UL84 PF06284.11 EGD97570.1 - 5.2 5.4 5.0 6.6 5.1 5.0 1.1 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein Adaptin_N PF01602.20 EGD97571.1 - 5.1e-97 325.6 0.0 6.1e-97 325.3 0.0 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 EGD97571.1 - 1.8e-16 60.6 0.0 6.5e-14 52.3 0.0 3.2 2 1 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EGD97571.1 - 1.3e-09 38.3 2.1 0.0007 19.9 0.0 4.6 3 1 1 4 4 4 4 HEAT repeats HEAT PF02985.22 EGD97571.1 - 6e-07 29.2 0.5 0.15 12.4 0.0 5.0 5 0 0 5 5 5 2 HEAT repeat SPO22 PF08631.10 EGD97571.1 - 0.0011 18.5 0.7 0.37 10.2 0.1 3.2 3 0 0 3 3 3 1 Meiosis protein SPO22/ZIP4 like Cohesin_HEAT PF12765.7 EGD97571.1 - 0.0094 16.2 0.8 1.1 9.7 0.0 3.9 4 0 0 4 4 4 1 HEAT repeat associated with sister chromatid cohesion VHS PF00790.19 EGD97571.1 - 0.11 12.3 1.4 76 3.1 0.0 4.0 5 0 0 5 5 5 0 VHS domain CENP-B_dimeris PF09026.10 EGD97571.1 - 0.27 11.6 0.1 0.27 11.6 0.1 4.5 3 1 0 3 3 3 0 Centromere protein B dimerisation domain Arm PF00514.23 EGD97571.1 - 0.33 11.0 1.8 6.3 7.0 0.2 3.7 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat Metallophos PF00149.28 EGD97572.1 - 0.0017 18.9 0.0 0.0023 18.5 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 EGD97572.1 - 0.0065 16.9 0.4 0.021 15.2 0.4 1.8 1 1 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain Rho_GDI PF02115.17 EGD97573.1 - 2e-64 217.0 0.2 2.2e-64 216.8 0.2 1.0 1 0 0 1 1 1 1 RHO protein GDP dissociation inhibitor GFA PF04828.14 EGD97574.1 - 4.7e-05 23.6 0.4 4.7e-05 23.6 0.4 1.9 2 0 0 2 2 2 1 Glutathione-dependent formaldehyde-activating enzyme Nudix_N_2 PF14803.6 EGD97574.1 - 0.0012 18.7 0.1 0.0012 18.7 0.1 2.6 3 0 0 3 3 3 1 Nudix N-terminal zf-NADH-PPase PF09297.11 EGD97574.1 - 0.0035 17.0 0.1 0.0035 17.0 0.1 2.2 2 0 0 2 2 2 1 NADH pyrophosphatase zinc ribbon domain zf-CSL PF05207.13 EGD97574.1 - 0.12 12.2 1.7 0.14 11.9 0.5 1.7 2 0 0 2 2 2 0 CSL zinc finger DUF4746 PF15928.5 EGD97575.1 - 0.0087 15.5 6.5 0.0087 15.5 6.5 2.1 1 1 1 2 2 2 1 Domain of unknown function (DUF4746) KilA-N PF04383.13 EGD97575.1 - 0.19 11.6 0.7 1.4 8.8 0.0 2.6 2 1 0 2 2 2 0 KilA-N domain RF-1 PF00472.20 EGD97575.1 - 6.6 6.7 10.2 2.7 7.9 2.3 2.4 2 0 0 2 2 2 0 RF-1 domain CLP1_P PF16575.5 EGD97576.1 - 2.2e-34 118.9 0.0 2.1e-33 115.7 0.0 2.2 1 1 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop CLP1_N PF16573.5 EGD97576.1 - 6.8e-33 112.8 0.0 1.3e-32 111.9 0.0 1.5 1 0 0 1 1 1 1 N-terminal beta-sandwich domain of polyadenylation factor Clp1 PF06807.14 EGD97576.1 - 1.2e-20 74.0 0.0 2.4e-20 73.1 0.0 1.5 1 0 0 1 1 1 1 Pre-mRNA cleavage complex II protein Clp1 ATP_bind_1 PF03029.17 EGD97576.1 - 0.00022 21.1 0.0 0.0026 17.6 0.0 2.0 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein MMR_HSR1 PF01926.23 EGD97576.1 - 0.0072 16.4 0.0 0.052 13.6 0.0 2.3 2 1 0 2 2 2 1 50S ribosome-binding GTPase ABC_tran PF00005.27 EGD97576.1 - 0.032 14.8 0.0 0.14 12.7 0.0 2.0 2 0 0 2 2 2 0 ABC transporter AAA_24 PF13479.6 EGD97576.1 - 0.043 13.5 0.0 0.058 13.1 0.0 1.2 1 0 0 1 1 1 0 AAA domain SRPRB PF09439.10 EGD97576.1 - 0.19 11.1 0.0 0.48 9.8 0.0 1.6 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_35 PF14516.6 EGD97576.1 - 0.3 9.9 0.0 0.46 9.3 0.0 1.2 1 0 0 1 1 1 0 AAA-like domain Host_attach PF10116.9 EGD97577.1 - 1.1 9.9 0.0 1.1 9.9 0.0 2.6 3 1 1 4 4 4 0 Protein required for attachment to host cells ADH_zinc_N PF00107.26 EGD97578.1 - 4.8e-26 91.3 0.1 9.3e-26 90.3 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EGD97578.1 - 5.2e-23 82.6 0.0 9.5e-23 81.7 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EGD97578.1 - 8.5e-07 28.8 0.0 1.6e-06 28.0 0.0 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_N_2 PF16884.5 EGD97578.1 - 0.035 14.0 0.0 0.063 13.2 0.0 1.4 1 0 0 1 1 1 0 N-terminal domain of oxidoreductase Arb1 PF09692.10 EGD97579.1 - 3.7e-96 322.7 0.1 6.9e-65 219.8 0.1 2.0 1 1 1 2 2 2 2 Argonaute siRNA chaperone (ARC) complex subunit Arb1 PG_binding_1 PF01471.18 EGD97579.1 - 0.073 13.3 0.0 0.15 12.3 0.0 1.5 1 0 0 1 1 1 0 Putative peptidoglycan binding domain IPK PF03770.16 EGD97580.1 - 2e-60 204.0 0.0 2.5e-60 203.7 0.0 1.1 1 0 0 1 1 1 1 Inositol polyphosphate kinase DNA_pol_phi PF04931.13 EGD97580.1 - 0.13 10.3 3.2 0.18 9.9 3.2 1.1 1 0 0 1 1 1 0 DNA polymerase phi Ribosomal_S19 PF00203.21 EGD97581.1 - 4.6e-25 87.3 0.0 5.8e-25 87.0 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S19 TFIID_30kDa PF03540.13 EGD97582.1 - 3.5e-22 78.1 0.1 6e-22 77.3 0.1 1.4 1 0 0 1 1 1 1 Transcription initiation factor TFIID 23-30kDa subunit FoP_duplication PF13865.6 EGD97582.1 - 6.2 7.4 6.5 32 5.2 6.5 2.2 1 1 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 TRF PF08558.10 EGD97583.1 - 1.8e-81 273.3 0.4 3.3e-81 272.4 0.4 1.4 1 0 0 1 1 1 1 Telomere repeat binding factor (TRF) Myb_DNA-binding PF00249.31 EGD97583.1 - 0.00051 20.2 0.0 0.001 19.2 0.0 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Rrn6 PF10214.9 EGD97583.1 - 0.85 8.0 26.0 0.026 13.0 18.5 2.0 2 0 0 2 2 2 0 RNA polymerase I-specific transcription-initiation factor His_Phos_2 PF00328.22 EGD97584.1 - 1.5e-07 31.1 0.0 2.6e-07 30.3 0.0 1.5 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) MFS_1 PF07690.16 EGD97586.1 - 2.1e-29 102.6 54.4 7.2e-26 90.9 56.0 2.7 2 1 0 2 2 2 2 Major Facilitator Superfamily UL41A PF17591.2 EGD97586.1 - 0.0034 17.5 3.1 0.0046 17.0 0.8 2.5 2 0 0 2 2 2 1 Herpesvirus UL41A PepSY_TM_like_2 PF16357.5 EGD97586.1 - 0.071 13.1 0.3 0.18 11.8 0.3 1.6 1 0 0 1 1 1 0 Putative PepSY_TM-like DUF4006 PF13179.6 EGD97586.1 - 0.15 12.0 0.0 0.81 9.6 0.0 2.3 1 0 0 1 1 1 0 Family of unknown function (DUF4006) DUF4267 PF14087.6 EGD97588.1 - 1.8e-26 92.4 5.2 2.2e-26 92.1 5.2 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4267) Pkinase PF00069.25 EGD97589.1 - 7.4e-75 251.7 0.0 9.9e-75 251.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD97589.1 - 6.6e-32 110.8 0.0 8.8e-23 80.9 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 EGD97589.1 - 1.3e-06 28.0 0.1 0.54 9.5 0.0 3.1 3 0 0 3 3 3 3 Kinase-like Pkinase_fungal PF17667.1 EGD97589.1 - 0.017 13.9 0.0 0.028 13.2 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase Kdo PF06293.14 EGD97589.1 - 0.026 13.9 0.0 0.052 12.9 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EGD97589.1 - 0.041 13.8 0.0 2.4 8.0 0.0 2.3 1 1 1 2 2 2 0 Phosphotransferase enzyme family Astro_capsid_p PF12226.8 EGD97590.1 - 0.55 9.3 5.9 0.72 8.9 5.9 1.1 1 0 0 1 1 1 0 Turkey astrovirus capsid protein DASH_Dad3 PF08656.10 EGD97591.1 - 1.7e-29 101.7 2.1 2e-29 101.5 2.1 1.0 1 0 0 1 1 1 1 DASH complex subunit Dad3 Peptidase_M75 PF09375.10 EGD97591.1 - 0.058 12.9 0.1 0.06 12.8 0.1 1.1 1 0 0 1 1 1 0 Imelysin SopE_GEF PF07487.13 EGD97591.1 - 0.19 11.8 0.0 0.23 11.5 0.0 1.2 1 0 0 1 1 1 0 SopE GEF domain Ribosomal_S5_C PF03719.15 EGD97592.1 - 2.1e-24 84.8 0.1 3.1e-23 81.0 0.0 2.4 2 0 0 2 2 2 1 Ribosomal protein S5, C-terminal domain Ribosomal_S5 PF00333.20 EGD97592.1 - 2.4e-21 75.5 0.2 5.2e-21 74.4 0.2 1.6 1 0 0 1 1 1 1 Ribosomal protein S5, N-terminal domain CRAL_TRIO PF00650.20 EGD97594.1 - 0.009 15.7 0.0 0.024 14.4 0.0 1.8 1 1 0 1 1 1 1 CRAL/TRIO domain tRNA_U5-meth_tr PF05958.11 EGD97595.1 - 3.4e-16 59.2 0.1 3.3e-14 52.7 0.0 2.7 2 1 0 2 2 2 1 tRNA (Uracil-5-)-methyltransferase Methyltransf_31 PF13847.6 EGD97595.1 - 7.3e-05 22.6 0.0 0.00015 21.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EGD97595.1 - 8e-05 23.3 0.1 0.00032 21.4 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_15 PF09445.10 EGD97595.1 - 0.00033 20.3 0.0 0.00065 19.3 0.0 1.5 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_11 PF08241.12 EGD97595.1 - 0.0013 19.3 0.1 0.021 15.4 0.0 2.5 2 0 0 2 2 2 1 Methyltransferase domain PrmA PF06325.13 EGD97595.1 - 0.03 13.7 0.0 0.066 12.6 0.0 1.5 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Actin PF00022.19 EGD97596.1 - 8.5e-88 294.7 0.0 8.6e-86 288.1 0.0 2.0 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 EGD97596.1 - 0.00014 20.8 0.1 0.0046 15.8 0.1 2.2 2 0 0 2 2 2 2 MreB/Mbl protein FtsA PF14450.6 EGD97596.1 - 0.0052 17.2 0.0 0.0076 16.6 0.0 1.4 1 0 0 1 1 1 1 Cell division protein FtsA Asparaginase_2 PF01112.18 EGD97597.1 - 4.2e-46 157.4 7.0 1.8e-30 106.0 0.0 2.2 2 0 0 2 2 2 2 Asparaginase SasG_E PF17041.5 EGD97597.1 - 0.0061 16.5 0.2 0.015 15.3 0.2 1.6 1 0 0 1 1 1 1 E domain PEHE PF15275.6 EGD97597.1 - 0.07 13.8 0.5 0.17 12.5 0.3 1.6 1 1 0 1 1 1 0 PEHE domain Tfb4 PF03850.14 EGD97598.1 - 2.4e-109 365.1 0.0 3.1e-109 364.7 0.0 1.1 1 0 0 1 1 1 1 Transcription factor Tfb4 UNC45-central PF11701.8 EGD97599.1 - 1.6e-45 154.8 4.3 4.1e-45 153.5 1.1 3.0 3 0 0 3 3 3 1 Myosin-binding striated muscle assembly central Atx10homo_assoc PF09759.9 EGD97599.1 - 0.0003 20.8 0.0 0.85 9.7 0.0 2.9 2 0 0 2 2 2 2 Spinocerebellar ataxia type 10 protein domain Arm PF00514.23 EGD97599.1 - 0.089 12.9 13.2 26 5.0 0.0 7.8 9 0 0 9 9 9 0 Armadillo/beta-catenin-like repeat Trp_halogenase PF04820.14 EGD97600.1 - 1.3e-28 100.1 0.2 7.7e-14 51.4 0.0 2.8 1 1 1 2 2 2 2 Tryptophan halogenase FAD_binding_3 PF01494.19 EGD97600.1 - 1.9e-09 37.3 0.0 3.9e-09 36.2 0.0 1.5 1 1 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 EGD97600.1 - 3.7e-05 23.9 0.2 3.7e-05 23.9 0.2 1.9 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.7 EGD97600.1 - 0.00047 19.6 0.5 0.0014 18.0 0.2 1.9 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EGD97600.1 - 0.0006 19.1 0.1 0.001 18.4 0.1 1.5 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EGD97600.1 - 0.0013 17.9 0.1 0.0029 16.8 0.1 1.5 1 0 0 1 1 1 1 Glucose inhibited division protein A HI0933_like PF03486.14 EGD97600.1 - 0.0031 16.3 0.1 0.006 15.3 0.1 1.4 1 0 0 1 1 1 1 HI0933-like protein FAD_binding_2 PF00890.24 EGD97600.1 - 0.0084 15.2 0.7 0.03 13.4 0.2 2.0 2 0 0 2 2 2 1 FAD binding domain TrkA_N PF02254.18 EGD97600.1 - 0.012 15.9 0.1 4.2 7.7 0.0 2.4 2 0 0 2 2 2 0 TrkA-N domain DAO PF01266.24 EGD97600.1 - 0.022 14.4 0.7 0.044 13.4 0.4 1.7 2 0 0 2 2 2 0 FAD dependent oxidoreductase p450 PF00067.22 EGD97601.1 - 5.2e-27 94.7 0.0 7e-27 94.3 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 EGD97602.1 - 3.1e-71 240.5 0.0 5.6e-71 239.7 0.0 1.3 1 1 0 1 1 1 1 Cytochrome P450 UPF0203 PF05254.12 EGD97602.1 - 0.14 12.4 0.5 18 5.6 0.1 2.4 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0203) AIG2_2 PF13772.6 EGD97605.1 - 6.2e-05 23.3 0.0 9.6e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 AIG2-like family MFS_1 PF07690.16 EGD97606.1 - 1.8e-45 155.4 44.6 1.8e-45 155.4 44.6 1.9 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EGD97606.1 - 1.7e-19 69.7 14.9 3.7e-19 68.6 14.9 1.5 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 EGD97606.1 - 7.1e-12 44.9 10.2 7.1e-12 44.9 10.2 3.1 1 1 2 3 3 3 1 Sugar (and other) transporter DUF1422 PF07226.11 EGD97606.1 - 0.0055 16.7 0.5 0.0055 16.7 0.5 2.6 3 0 0 3 3 3 1 Protein of unknown function (DUF1422) PsbY PF06298.11 EGD97606.1 - 0.022 14.6 0.3 0.022 14.6 0.3 1.9 2 0 0 2 2 2 0 Photosystem II protein Y (PsbY) ABC_tran PF00005.27 EGD97607.1 - 3.8e-32 111.7 0.0 7.3e-32 110.7 0.0 1.5 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 EGD97607.1 - 1.1e-25 90.8 16.1 1.6e-25 90.3 16.1 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.19 EGD97607.1 - 2.4e-07 30.4 0.0 0.00043 19.8 0.0 2.3 1 1 1 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EGD97607.1 - 0.00076 19.2 0.1 0.0019 17.9 0.1 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_22 PF13401.6 EGD97607.1 - 0.00078 19.7 0.0 0.0042 17.4 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EGD97607.1 - 0.0027 18.1 0.2 0.013 15.9 0.0 2.0 2 0 0 2 2 2 1 AAA ATPase domain SbcCD_C PF13558.6 EGD97607.1 - 0.0093 16.2 0.3 0.24 11.7 0.3 2.5 1 1 0 1 1 1 1 Putative exonuclease SbcCD, C subunit AAA_21 PF13304.6 EGD97607.1 - 0.012 15.4 0.0 0.03 14.1 0.0 1.6 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 EGD97607.1 - 0.012 16.1 0.0 0.025 15.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 EGD97607.1 - 0.026 14.4 0.0 0.058 13.3 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase AAA_10 PF12846.7 EGD97607.1 - 0.034 13.1 0.0 0.049 12.5 0.0 1.3 1 0 0 1 1 1 0 AAA-like domain AAA_30 PF13604.6 EGD97607.1 - 0.046 13.5 0.1 0.093 12.4 0.1 1.6 1 1 0 1 1 1 0 AAA domain AAA_15 PF13175.6 EGD97607.1 - 0.056 13.1 0.0 0.087 12.5 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain DUF87 PF01935.17 EGD97607.1 - 0.059 13.4 0.2 0.17 12.0 0.1 1.7 2 0 0 2 2 2 0 Helicase HerA, central domain AAA_24 PF13479.6 EGD97607.1 - 0.063 13.0 0.0 0.14 11.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain TmoB PF06234.12 EGD97607.1 - 0.083 13.0 0.0 0.18 11.9 0.0 1.6 1 0 0 1 1 1 0 Toluene-4-monooxygenase system protein B (TmoB) Zeta_toxin PF06414.12 EGD97607.1 - 0.1 11.8 0.0 0.26 10.5 0.0 1.6 1 0 0 1 1 1 0 Zeta toxin AAA PF00004.29 EGD97607.1 - 0.15 12.5 0.0 1.1 9.7 0.0 2.1 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Aminotran_1_2 PF00155.21 EGD97608.1 - 3.1e-41 141.8 0.0 3.6e-41 141.5 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II DUF1382 PF07131.11 EGD97608.1 - 0.21 11.6 0.9 1.8 8.6 0.1 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1382) MBOAT_2 PF13813.6 EGD97609.1 - 5.8e-22 77.8 1.1 1e-21 77.0 1.1 1.4 1 0 0 1 1 1 1 Membrane bound O-acyl transferase family p450 PF00067.22 EGD97610.1 - 8.2e-36 123.7 0.0 1.2e-35 123.2 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Pyr_redox_2 PF07992.14 EGD97611.1 - 1.1e-18 67.5 0.0 1.9e-17 63.5 0.0 2.0 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EGD97611.1 - 0.00016 21.7 0.5 1.2 9.1 0.3 3.5 2 2 2 4 4 4 2 FAD-NAD(P)-binding DAO PF01266.24 EGD97611.1 - 0.00023 20.9 0.4 0.0068 16.0 0.1 2.3 2 1 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EGD97611.1 - 0.001 18.2 0.1 0.0023 17.1 0.1 1.5 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 EGD97611.1 - 0.0014 18.8 0.5 0.003 17.7 0.5 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 EGD97611.1 - 0.0023 17.2 0.4 2.1 7.5 0.2 3.2 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EGD97611.1 - 0.034 12.8 0.2 0.17 10.6 0.1 2.0 2 0 0 2 2 2 0 HI0933-like protein GIDA PF01134.22 EGD97611.1 - 0.041 13.0 0.0 0.08 12.0 0.0 1.5 1 0 0 1 1 1 0 Glucose inhibited division protein A AlaDh_PNT_C PF01262.21 EGD97611.1 - 0.045 13.0 0.0 0.094 12.0 0.0 1.5 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox_2 PF07992.14 EGD97613.1 - 1.8e-10 40.5 0.0 4.1e-10 39.4 0.0 1.6 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EGD97613.1 - 0.00028 20.3 0.1 0.0016 17.8 0.0 2.1 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 EGD97613.1 - 0.0006 19.1 0.0 0.0011 18.4 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain FAD_binding_2 PF00890.24 EGD97613.1 - 0.002 17.3 0.0 0.0028 16.8 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 EGD97613.1 - 0.0024 18.0 0.1 0.0052 17.0 0.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 EGD97613.1 - 0.0086 14.8 0.2 0.048 12.4 0.1 2.0 2 0 0 2 2 2 1 HI0933-like protein FAD_oxidored PF12831.7 EGD97613.1 - 0.069 12.5 3.0 0.091 12.1 2.6 1.4 1 1 0 1 1 1 0 FAD dependent oxidoreductase GIDA PF01134.22 EGD97613.1 - 0.081 12.0 0.1 0.29 10.2 0.1 1.9 3 0 0 3 3 3 0 Glucose inhibited division protein A NAD_binding_7 PF13241.6 EGD97613.1 - 0.13 12.8 0.0 0.38 11.2 0.0 1.8 1 1 0 1 1 1 0 Putative NAD(P)-binding Thi4 PF01946.17 EGD97613.1 - 0.17 11.1 0.1 0.28 10.4 0.1 1.3 1 0 0 1 1 1 0 Thi4 family NAD_binding_9 PF13454.6 EGD97613.1 - 0.2 11.6 4.2 1.4 8.9 0.9 2.5 1 1 0 2 2 2 0 FAD-NAD(P)-binding DAO PF01266.24 EGD97613.1 - 0.7 9.4 4.1 0.86 9.1 1.6 2.0 1 1 1 2 2 2 0 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EGD97614.1 - 2e-16 60.1 0.0 2.8e-16 59.6 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EGD97614.1 - 0.0001 21.6 0.2 0.00039 19.6 0.1 1.8 1 1 1 2 2 2 1 Glucose inhibited division protein A NAD_binding_8 PF13450.6 EGD97614.1 - 0.0001 22.4 0.1 0.00035 20.7 0.0 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Trp_halogenase PF04820.14 EGD97614.1 - 0.00017 20.6 0.0 0.00045 19.2 0.0 1.6 2 0 0 2 2 2 1 Tryptophan halogenase NAD_binding_9 PF13454.6 EGD97614.1 - 0.00042 20.3 0.0 3.3 7.7 0.0 3.3 3 0 0 3 3 3 2 FAD-NAD(P)-binding HI0933_like PF03486.14 EGD97614.1 - 0.00092 18.0 0.0 0.0052 15.5 0.0 1.9 2 0 0 2 2 2 1 HI0933-like protein DAO PF01266.24 EGD97614.1 - 0.0013 18.4 0.7 0.0048 16.5 0.2 2.0 1 1 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EGD97614.1 - 0.0038 16.4 0.1 0.0087 15.2 0.0 1.6 2 0 0 2 2 2 1 FAD binding domain FAD_binding_3 PF01494.19 EGD97614.1 - 0.0052 16.1 0.0 0.0086 15.4 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_3 PF13738.6 EGD97614.1 - 0.011 15.0 0.0 0.021 14.1 0.0 1.4 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EGD97614.1 - 0.026 13.8 0.0 0.038 13.2 0.0 1.2 1 0 0 1 1 1 0 Thi4 family Lycopene_cycl PF05834.12 EGD97614.1 - 0.027 13.5 0.0 0.32 10.0 0.0 2.6 3 0 0 3 3 3 0 Lycopene cyclase protein FAD_oxidored PF12831.7 EGD97614.1 - 0.057 12.8 0.1 0.057 12.8 0.1 1.8 2 0 0 2 2 2 0 FAD dependent oxidoreductase AlaDh_PNT_C PF01262.21 EGD97614.1 - 0.14 11.4 1.1 0.2 11.0 0.0 1.7 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain Methyltransf_2 PF00891.18 EGD97615.1 - 5.5e-31 107.5 0.0 1.3e-30 106.2 0.0 1.8 1 1 0 1 1 1 1 O-methyltransferase domain Methyltransf_23 PF13489.6 EGD97615.1 - 0.0048 16.8 0.0 0.01 15.7 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EGD97615.1 - 0.16 12.7 0.0 0.85 10.4 0.0 2.3 2 1 0 2 2 2 0 Methyltransferase domain GST_C PF00043.25 EGD97616.1 - 2.8e-07 30.7 0.0 4.6e-07 30.0 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EGD97616.1 - 2.2e-06 27.8 0.0 3.8e-06 27.0 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 EGD97616.1 - 5.1e-05 23.5 0.1 0.0001 22.5 0.1 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 EGD97616.1 - 6.6e-05 23.2 0.0 0.00012 22.4 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EGD97616.1 - 0.00016 21.6 0.1 0.0003 20.8 0.1 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EGD97616.1 - 0.0047 17.2 0.0 0.0091 16.3 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Tom37 PF10568.9 EGD97616.1 - 0.068 13.5 0.0 0.13 12.6 0.0 1.5 1 1 0 1 1 1 0 Outer mitochondrial membrane transport complex protein p450 PF00067.22 EGD97617.1 - 6.1e-51 173.6 0.0 8.2e-51 173.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Peptidase_M19 PF01244.21 EGD97618.1 - 7.3e-102 340.8 0.0 8.5e-102 340.6 0.0 1.0 1 0 0 1 1 1 1 Membrane dipeptidase (Peptidase family M19) HAS-barrel PF09378.10 EGD97618.1 - 0.061 13.5 0.0 14 5.9 0.1 2.3 2 0 0 2 2 2 0 HAS barrel domain DUF2113 PF09886.9 EGD97618.1 - 0.062 12.6 0.0 0.1 11.9 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2113) Stig1 PF04885.13 EGD97619.1 - 7.9e-34 117.1 194.9 0.00035 21.1 19.3 9.2 1 1 8 9 9 9 9 Stigma-specific protein, Stig1 AMP-binding PF00501.28 EGD97620.1 - 9.9e-77 258.3 0.0 1.4e-76 257.8 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme Condensation PF00668.20 EGD97620.1 - 1.9e-51 175.2 0.0 1.3e-27 96.6 0.0 2.8 2 1 0 2 2 2 2 Condensation domain PP-binding PF00550.25 EGD97620.1 - 3.9e-07 30.3 0.0 1.1e-06 28.9 0.0 1.8 1 0 0 1 1 1 1 Phosphopantetheine attachment site AMP-binding_C PF13193.6 EGD97620.1 - 0.015 16.2 0.1 0.041 14.9 0.1 1.7 1 0 0 1 1 1 0 AMP-binding enzyme C-terminal domain Transp_cyt_pur PF02133.15 EGD97621.1 - 6.4e-80 269.1 32.0 2.9e-79 266.9 32.0 1.8 1 1 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin GFO_IDH_MocA PF01408.22 EGD97622.1 - 4.8e-15 56.4 0.1 7.4e-15 55.8 0.1 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 EGD97622.1 - 1.5e-05 25.0 0.0 7e-05 22.8 0.0 2.2 2 1 0 2 2 2 1 Oxidoreductase family, C-terminal alpha/beta domain NAD_binding_3 PF03447.16 EGD97622.1 - 0.0088 16.7 0.2 0.016 15.8 0.2 1.4 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain ADSL_C PF10397.9 EGD97622.1 - 0.097 13.2 0.6 1.5 9.4 0.6 2.3 1 1 0 1 1 1 0 Adenylosuccinate lyase C-terminus DUF1489 PF07370.11 EGD97622.1 - 0.12 12.1 0.0 0.24 11.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1489) Methyltransf_2 PF00891.18 EGD97623.1 - 1e-27 96.8 0.0 2e-27 95.9 0.0 1.4 1 0 0 1 1 1 1 O-methyltransferase domain Dimerisation2 PF16864.5 EGD97623.1 - 0.00065 19.6 0.0 0.0017 18.3 0.0 1.7 1 0 0 1 1 1 1 Dimerisation domain Rrf2 PF02082.20 EGD97623.1 - 0.026 14.9 0.0 0.067 13.6 0.0 1.6 1 0 0 1 1 1 0 Transcriptional regulator PDZ_3 PF17815.1 EGD97623.1 - 0.14 12.0 0.0 0.27 11.1 0.0 1.4 1 0 0 1 1 1 0 PDZ domain GDPD PF03009.17 EGD97626.1 - 2.4e-65 220.8 0.0 5.5e-65 219.7 0.0 1.7 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family Ank_2 PF12796.7 EGD97626.1 - 3.9e-25 88.2 0.2 2.3e-07 31.3 0.5 3.6 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EGD97626.1 - 8.2e-24 83.7 0.6 2.4e-08 34.4 0.1 4.7 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 EGD97626.1 - 7.1e-18 64.2 3.3 0.0015 18.9 0.0 6.1 4 1 0 4 4 4 4 Ankyrin repeat SPX PF03105.19 EGD97626.1 - 8.4e-17 62.2 21.4 3.5e-11 43.6 0.2 4.3 3 2 1 4 4 4 3 SPX domain Ank_5 PF13857.6 EGD97626.1 - 8.9e-15 54.6 0.1 1.5e-05 25.2 0.0 4.5 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EGD97626.1 - 5.2e-14 51.0 0.9 0.031 14.8 0.0 6.0 6 0 0 6 6 6 3 Ankyrin repeat TAT_signal PF10518.9 EGD97626.1 - 0.037 13.9 0.1 0.84 9.6 0.1 2.6 2 0 0 2 2 2 0 TAT (twin-arginine translocation) pathway signal sequence PRMT5 PF05185.16 EGD97627.1 - 3.8e-65 218.9 0.0 5.5e-65 218.4 0.0 1.2 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase PRMT5_C PF17286.2 EGD97627.1 - 2.1e-58 197.1 0.0 4.3e-58 196.1 0.0 1.6 1 0 0 1 1 1 1 PRMT5 oligomerisation domain PRMT5_TIM PF17285.2 EGD97627.1 - 4.6e-54 183.3 0.0 6.7e-54 182.8 0.0 1.2 1 0 0 1 1 1 1 PRMT5 TIM barrel domain OB_NTP_bind PF07717.16 EGD97628.1 - 6.2e-21 74.6 0.0 1.7e-20 73.2 0.0 1.8 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.23 EGD97628.1 - 6.1e-19 68.3 0.0 1.6e-18 66.9 0.0 1.7 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.31 EGD97628.1 - 3e-10 40.4 0.0 7.7e-10 39.1 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 EGD97628.1 - 3.7e-07 30.1 0.1 6.5e-07 29.3 0.1 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 EGD97628.1 - 2.9e-05 24.3 0.0 9.9e-05 22.6 0.0 1.9 1 0 0 1 1 1 1 AAA domain SRP54 PF00448.22 EGD97628.1 - 0.00027 20.6 0.1 0.00075 19.2 0.1 1.7 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain AAA_19 PF13245.6 EGD97628.1 - 0.0024 18.2 0.1 0.0049 17.2 0.1 1.5 1 0 0 1 1 1 1 AAA domain Flavi_DEAD PF07652.14 EGD97628.1 - 0.0025 17.8 0.1 0.0046 16.9 0.1 1.4 1 0 0 1 1 1 1 Flavivirus DEAD domain AAA_30 PF13604.6 EGD97628.1 - 0.0042 16.8 0.0 0.0071 16.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_23 PF13476.6 EGD97628.1 - 0.042 14.4 0.0 0.077 13.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain T2SSE PF00437.20 EGD97628.1 - 0.1 11.6 0.0 0.2 10.7 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein DUF2075 PF09848.9 EGD97628.1 - 0.19 10.9 0.0 0.32 10.2 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) EF-hand_6 PF13405.6 EGD97630.1 - 6.2e-09 35.1 0.7 0.00031 20.4 0.1 2.9 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.6 EGD97630.1 - 1.8e-05 25.1 0.5 9.1e-05 22.8 0.2 2.1 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.32 EGD97630.1 - 0.0074 15.8 0.0 1.3 8.8 0.0 2.4 2 0 0 2 2 2 2 EF hand Met_10 PF02475.16 EGD97631.1 - 0.00011 22.0 0.1 0.00066 19.5 0.0 2.1 2 1 0 2 2 2 1 Met-10+ like-protein HpaP PF09483.10 EGD97632.1 - 0.0093 16.2 0.0 0.018 15.3 0.0 1.5 1 0 0 1 1 1 1 Type III secretion protein (HpaP) MFS_1 PF07690.16 EGD97634.1 - 2e-22 79.6 44.4 2.6e-18 66.1 20.9 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily ANAPC4_WD40 PF12894.7 EGD97635.1 - 1.3e-05 25.4 0.0 0.037 14.3 0.0 4.0 2 2 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EGD97635.1 - 7.1e-05 23.5 0.2 0.034 15.0 0.0 4.1 4 0 0 4 4 4 1 WD domain, G-beta repeat CNH PF00780.22 EGD97635.1 - 0.0046 16.6 0.2 1.6 8.3 0.1 3.4 3 1 0 3 3 3 1 CNH domain Coatomer_WDAD PF04053.14 EGD97635.1 - 0.0055 15.8 0.0 0.72 8.8 0.0 2.4 2 0 0 2 2 2 2 Coatomer WD associated region Big_7 PF17957.1 EGD97635.1 - 0.026 15.3 0.5 0.55 11.0 0.0 2.6 2 0 0 2 2 2 0 Bacterial Ig domain Hira PF07569.11 EGD97635.1 - 0.15 11.8 0.1 20 4.8 0.0 2.7 3 0 0 3 3 3 0 TUP1-like enhancer of split Kelch_4 PF13418.6 EGD97636.1 - 6.2e-13 48.5 19.2 1.2e-07 31.6 0.0 6.3 6 0 0 6 6 6 3 Galactose oxidase, central domain Kelch_3 PF13415.6 EGD97636.1 - 0.00014 22.1 9.5 0.0032 17.7 0.0 4.6 5 1 0 5 5 5 2 Galactose oxidase, central domain Kelch_5 PF13854.6 EGD97636.1 - 0.0026 17.7 7.9 0.11 12.5 0.1 4.4 5 0 0 5 5 5 2 Kelch motif Kelch_2 PF07646.15 EGD97636.1 - 0.048 13.7 10.5 2.5 8.2 0.8 4.7 5 0 0 5 5 5 0 Kelch motif LCM PF04072.14 EGD97636.1 - 0.11 12.5 0.0 0.17 11.8 0.0 1.3 1 0 0 1 1 1 0 Leucine carboxyl methyltransferase Kelch_6 PF13964.6 EGD97636.1 - 0.13 12.6 4.1 6.4 7.2 0.2 3.8 4 0 0 4 4 4 0 Kelch motif DSPc PF00782.20 EGD97638.1 - 4.1e-27 94.6 0.0 1.3e-19 70.3 0.0 2.3 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EGD97638.1 - 0.002 17.8 0.0 0.011 15.3 0.0 1.9 2 0 0 2 2 2 1 Protein-tyrosine phosphatase RSN1_TM PF13967.6 EGD97639.1 - 0.11 12.2 0.0 0.19 11.5 0.0 1.3 1 0 0 1 1 1 0 Late exocytosis, associated with Golgi transport Mlh1_C PF16413.5 EGD97640.1 - 3.8e-104 347.8 0.0 6e-104 347.2 0.0 1.3 1 0 0 1 1 1 1 DNA mismatch repair protein Mlh1 C-terminus DNA_mis_repair PF01119.19 EGD97640.1 - 6.1e-32 109.8 0.1 1.8e-31 108.3 0.0 1.8 2 0 0 2 2 2 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.6 EGD97640.1 - 3.3e-13 49.7 0.0 6.6e-13 48.7 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 EGD97640.1 - 1.1e-06 29.1 0.0 5.9e-06 26.8 0.0 2.2 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase RPN1_RPN2_N PF17781.1 EGD97642.1 - 4.5e-118 394.2 5.5 8e-118 393.3 5.5 1.4 1 0 0 1 1 1 1 RPN1/RPN2 N-terminal domain RPN1_C PF18051.1 EGD97642.1 - 4.3e-29 100.3 0.0 8e-29 99.5 0.0 1.5 1 0 0 1 1 1 1 26S proteasome non-ATPase regulatory subunit RPN1 C-terminal PC_rep PF01851.22 EGD97642.1 - 1.3e-19 69.5 16.2 7.2e-05 23.0 0.1 8.0 7 1 0 7 7 7 3 Proteasome/cyclosome repeat HEAT_2 PF13646.6 EGD97642.1 - 0.0028 18.0 1.2 3.2 8.2 0.0 4.2 5 2 1 6 6 6 2 HEAT repeats EMC3_TMCO1 PF01956.16 EGD97642.1 - 0.14 11.8 0.1 19 5.0 0.0 2.3 2 0 0 2 2 2 0 Integral membrane protein EMC3/TMCO1-like TetR_C_35 PF18556.1 EGD97643.1 - 0.13 12.4 0.0 0.36 11.0 0.0 1.7 2 0 0 2 2 2 0 Bacterial Tetracyclin repressor, C-terminal domain Cyclin PF08613.11 EGD97645.1 - 1.1e-12 48.6 0.6 1.1e-12 48.6 0.6 1.9 2 1 0 2 2 2 1 Cyclin Cyclin_N PF00134.23 EGD97645.1 - 0.0066 16.2 0.0 0.011 15.5 0.0 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain Pyr_redox_2 PF07992.14 EGD97648.1 - 1.9e-52 178.3 0.1 2.7e-52 177.9 0.1 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EGD97648.1 - 1.4e-10 41.6 0.0 3.4e-09 37.1 0.0 2.8 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EGD97648.1 - 0.0033 16.7 0.1 3.1 7.0 0.1 2.7 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase EcoR124_C PF12008.8 EGD97648.1 - 0.028 14.1 1.0 0.076 12.6 0.0 1.9 2 0 0 2 2 2 0 Type I restriction and modification enzyme - subunit R C terminal DUF4381 PF14316.6 EGD97649.1 - 0.054 13.7 0.1 0.089 13.0 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) Trp_oprn_chp PF09534.10 EGD97649.1 - 0.063 13.1 0.0 0.1 12.4 0.0 1.3 1 0 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) DUF2681 PF10883.8 EGD97649.1 - 0.073 13.5 0.0 0.11 12.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2681) ASFV_J13L PF05568.11 EGD97649.1 - 0.79 9.5 3.1 12 5.6 0.7 2.4 2 0 0 2 2 2 0 African swine fever virus J13L protein Acetyltransf_7 PF13508.7 EGD97650.1 - 5.8e-10 39.5 0.1 1.1e-09 38.6 0.1 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EGD97650.1 - 7.2e-10 38.9 0.0 1.1e-09 38.2 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EGD97650.1 - 1.3e-09 38.3 0.0 2.7e-09 37.3 0.0 1.6 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_9 PF13527.7 EGD97650.1 - 1.4e-05 25.2 0.0 0.016 15.3 0.0 2.3 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain FR47 PF08445.10 EGD97650.1 - 2.1e-05 24.4 0.0 3.7e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_CG PF14542.6 EGD97650.1 - 0.0022 18.1 0.0 0.0034 17.5 0.0 1.3 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Arrestin_C PF02752.22 EGD97651.1 - 5.5e-15 56.0 0.1 2.8e-14 53.7 0.0 2.4 2 1 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 EGD97651.1 - 2.2e-06 27.8 0.0 0.0014 18.7 0.0 2.9 3 0 0 3 3 3 2 Arrestin (or S-antigen), N-terminal domain RRM_1 PF00076.22 EGD97653.1 - 9.1e-49 163.2 0.0 1e-20 73.3 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EGD97653.1 - 3.6e-06 26.7 0.0 0.008 16.0 0.0 3.2 3 0 0 3 3 3 1 Occluded RNA-recognition motif Cas_Cas2CT1978 PF09707.10 EGD97653.1 - 0.00061 19.8 0.0 0.77 9.9 0.0 2.4 2 0 0 2 2 2 2 CRISPR-associated protein (Cas_Cas2CT1978) RRM_5 PF13893.6 EGD97653.1 - 0.0016 18.0 0.0 1.2 8.8 0.0 2.9 2 1 1 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_8 PF11835.8 EGD97653.1 - 0.0059 16.8 0.0 0.35 11.1 0.0 2.3 1 1 1 2 2 2 1 RRM-like domain RRM_7 PF16367.5 EGD97653.1 - 0.0081 16.3 0.0 7.6 6.7 0.0 3.2 3 0 0 3 3 3 2 RNA recognition motif Nup35_RRM PF05172.13 EGD97653.1 - 0.011 15.6 0.0 8.1 6.5 0.0 3.1 2 1 0 2 2 2 0 Nup53/35/40-type RNA recognition motif Nup35_RRM_2 PF14605.6 EGD97653.1 - 0.03 14.3 0.1 7.4 6.7 0.0 2.7 3 0 0 3 3 3 0 Nup53/35/40-type RNA recognition motif PIG-Y PF15159.6 EGD97654.1 - 9.1e-24 84.2 8.6 1.5e-23 83.5 8.6 1.3 1 0 0 1 1 1 1 Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y DUF1218 PF06749.12 EGD97654.1 - 0.4 11.2 4.5 3.9 8.0 0.6 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1218) GATase_4 PF13230.6 EGD97655.1 - 1.5e-14 53.6 0.0 9.9e-13 47.6 0.0 2.1 1 1 0 1 1 1 1 Glutamine amidotransferases class-II GATase_6 PF13522.6 EGD97655.1 - 4.6e-07 30.1 0.0 7.8e-07 29.4 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase domain Kazal_2 PF07648.15 EGD97656.1 - 4.5e-09 36.3 4.0 6.6e-09 35.8 4.0 1.3 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.21 EGD97656.1 - 3.8e-07 30.0 2.1 5.6e-07 29.5 2.1 1.4 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain GDC-P PF02347.16 EGD97656.1 - 0.21 10.4 0.0 0.28 10.0 0.0 1.1 1 0 0 1 1 1 0 Glycine cleavage system P-protein Dynamin_N PF00350.23 EGD97657.1 - 8.8e-26 91.0 0.3 5e-17 62.5 0.1 2.7 1 1 1 2 2 2 2 Dynamin family Dynamin_M PF01031.20 EGD97657.1 - 1.9e-12 47.0 0.0 4.8e-10 39.1 0.0 2.4 2 0 0 2 2 2 2 Dynamin central region AAA_16 PF13191.6 EGD97657.1 - 0.0022 18.4 0.6 0.058 13.8 0.0 2.9 3 1 0 3 3 3 1 AAA ATPase domain AAA_15 PF13175.6 EGD97657.1 - 0.0099 15.6 0.7 0.19 11.4 0.1 2.4 2 0 0 2 2 2 1 AAA ATPase domain MMR_HSR1 PF01926.23 EGD97657.1 - 0.028 14.5 0.0 0.076 13.1 0.0 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_21 PF13304.6 EGD97657.1 - 0.032 14.0 0.0 0.091 12.5 0.0 1.8 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_28 PF13521.6 EGD97657.1 - 0.16 12.2 0.1 1.3 9.3 0.0 2.3 2 0 0 2 2 2 0 AAA domain Ribosomal_S6 PF01250.17 EGD97658.1 - 5.7e-23 81.0 0.0 7.4e-23 80.6 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S6 GCV_H PF01597.19 EGD97659.1 - 1e-38 131.9 0.3 1.2e-38 131.8 0.3 1.0 1 0 0 1 1 1 1 Glycine cleavage H-protein RnfC_N PF13375.6 EGD97659.1 - 0.00073 19.5 0.2 0.0011 18.9 0.2 1.3 1 0 0 1 1 1 1 RnfC Barrel sandwich hybrid domain Biotin_lipoyl PF00364.22 EGD97659.1 - 0.022 14.6 0.9 0.022 14.6 0.9 2.0 2 1 0 2 2 2 0 Biotin-requiring enzyme GvpO PF05800.11 EGD97659.1 - 0.14 12.2 0.3 0.26 11.3 0.2 1.6 2 0 0 2 2 2 0 Gas vesicle synthesis protein GvpO zf-rbx1 PF12678.7 EGD97660.1 - 2e-09 37.6 3.4 5.7e-09 36.1 3.4 1.8 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 EGD97660.1 - 3.7e-08 33.6 8.0 1.2e-07 32.0 4.1 2.3 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 EGD97660.1 - 2e-07 30.7 7.0 5.2e-07 29.4 2.3 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EGD97660.1 - 1.1e-06 28.4 3.5 3.3e-06 26.9 3.5 1.8 1 1 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 EGD97660.1 - 5.5e-06 26.1 2.2 9.5e-06 25.4 2.2 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EGD97660.1 - 0.00012 21.8 1.8 0.00012 21.8 1.8 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EGD97660.1 - 0.0002 21.2 1.4 0.0002 21.2 1.4 1.9 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 EGD97660.1 - 0.00043 20.3 7.4 0.0011 18.9 2.8 3.2 1 1 1 2 2 2 1 RING-type zinc-finger zf-RING_11 PF17123.5 EGD97660.1 - 0.0016 18.1 10.1 0.0025 17.5 0.8 3.3 3 0 0 3 3 3 1 RING-like zinc finger Zn_ribbon_17 PF17120.5 EGD97660.1 - 0.013 15.1 1.6 0.013 15.1 1.6 1.6 2 0 0 2 2 1 0 Zinc-ribbon, C4HC2 type zf-ANAPC11 PF12861.7 EGD97660.1 - 0.025 14.6 3.7 0.057 13.5 3.7 1.6 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger DUF2921 PF11145.8 EGD97660.1 - 0.054 11.3 1.3 0.1 10.5 1.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2921) PQ-loop PF04193.14 EGD97660.1 - 0.78 9.6 8.4 2.1 8.2 2.7 2.8 2 0 0 2 2 2 0 PQ loop repeat FANCL_C PF11793.8 EGD97660.1 - 1.8 8.8 5.8 5 7.4 3.5 2.5 2 1 0 2 2 2 0 FANCL C-terminal domain RINGv PF12906.7 EGD97660.1 - 3.9 7.7 6.9 0.41 10.8 2.0 1.8 2 0 0 2 2 2 0 RING-variant domain zf-C3H2C3 PF17122.5 EGD97660.1 - 6 7.0 4.8 2.6 8.2 1.2 2.1 2 0 0 2 2 2 0 Zinc-finger Cation_efflux PF01545.21 EGD97661.1 - 3.2e-14 53.2 11.7 4.2e-14 52.8 11.7 1.1 1 0 0 1 1 1 1 Cation efflux family DnaB_2 PF07261.11 EGD97662.1 - 0.05 13.4 0.0 0.17 11.7 0.0 1.9 2 0 0 2 2 2 0 Replication initiation and membrane attachment COMPASS-Shg1 PF05205.12 EGD97664.1 - 8.1e-10 39.3 0.1 8.1e-10 39.3 0.1 3.2 3 1 1 4 4 4 2 COMPASS (Complex proteins associated with Set1p) component shg1 IF4E PF01652.18 EGD97665.1 - 1.2e-29 103.1 0.2 1.6e-29 102.7 0.2 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E DUF2517 PF10725.9 EGD97665.1 - 0.067 13.0 0.1 2.2 8.1 0.0 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF2517) 2Fe-2S_thioredx PF01257.19 EGD97665.1 - 0.12 12.2 0.0 0.21 11.4 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin-like [2Fe-2S] ferredoxin DUF4598 PF15370.6 EGD97666.1 - 5.4e-28 97.7 5.1 5.4e-28 97.7 5.1 2.9 2 1 0 2 2 2 1 Domain of unknown function (DUF4598) CENP-B_dimeris PF09026.10 EGD97666.1 - 2.3 8.7 10.7 0.18 12.2 2.1 2.4 2 0 0 2 2 2 0 Centromere protein B dimerisation domain GDA1_CD39 PF01150.17 EGD97667.1 - 2e-101 339.7 0.0 2.5e-101 339.4 0.0 1.0 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family IF3_C PF00707.22 EGD97668.1 - 2.1e-10 40.4 1.0 3.2e-10 39.8 1.0 1.3 1 0 0 1 1 1 1 Translation initiation factor IF-3, C-terminal domain IF3_N PF05198.16 EGD97668.1 - 5.4e-09 36.2 1.9 2.4e-08 34.1 0.1 2.2 2 0 0 2 2 2 1 Translation initiation factor IF-3, N-terminal domain mIF3 PF14877.6 EGD97668.1 - 2.1e-06 27.5 2.0 1.7e-05 24.5 1.8 2.0 1 1 1 2 2 2 1 Mitochondrial translation initiation factor GTP_EFTU PF00009.27 EGD97669.1 - 1.1e-57 194.8 0.0 1.5e-57 194.3 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 EGD97669.1 - 2.3e-21 76.2 0.0 4.7e-21 75.2 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 EGD97669.1 - 2.6e-17 63.0 1.7 6.3e-17 61.7 1.7 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EGD97669.1 - 2.2e-05 24.5 0.0 4.9e-05 23.4 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase cobW PF02492.19 EGD97669.1 - 0.016 14.8 0.2 0.13 11.8 0.0 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain RsgA_GTPase PF03193.16 EGD97669.1 - 0.035 14.0 0.0 0.12 12.3 0.0 1.8 2 0 0 2 2 2 0 RsgA GTPase PduV-EutP PF10662.9 EGD97669.1 - 0.041 13.6 0.2 6.6 6.5 0.1 2.3 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation SCAB-ABD PF16711.5 EGD97669.1 - 0.056 13.3 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 Actin-binding domain of plant-specific actin-binding protein Radical_SAM PF04055.21 EGD97670.1 - 5e-15 56.3 0.1 2.7e-14 53.9 0.1 2.0 1 1 0 1 1 1 1 Radical SAM superfamily Fer4_12 PF13353.6 EGD97670.1 - 1.3e-07 32.0 0.3 2.8e-07 30.9 0.1 1.6 2 0 0 2 2 2 1 4Fe-4S single cluster domain Fer4_14 PF13394.6 EGD97670.1 - 5.1e-07 29.8 0.0 1e-06 28.9 0.0 1.4 1 0 0 1 1 1 1 4Fe-4S single cluster domain DUF3222 PF11519.8 EGD97672.1 - 0.19 12.0 0.0 0.27 11.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3222) bZIP_1 PF00170.21 EGD97673.1 - 0.00018 21.6 12.2 0.00033 20.7 12.2 1.5 1 0 0 1 1 1 1 bZIP transcription factor YabA PF06156.13 EGD97673.1 - 0.1 13.2 0.1 0.29 11.8 0.1 1.7 1 1 0 1 1 1 0 Initiation control protein YabA DUF2205 PF10224.9 EGD97673.1 - 0.16 12.0 5.8 0.41 10.7 5.8 1.7 1 0 0 1 1 1 0 Short coiled-coil protein DUF4072 PF13284.6 EGD97673.1 - 0.27 11.7 2.0 1.1 9.8 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4072) GvpL_GvpF PF06386.11 EGD97673.1 - 0.71 9.7 5.3 1.1 9.2 5.3 1.2 1 0 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF MFS_1 PF07690.16 EGD97674.1 - 2.6e-36 125.3 53.9 2.6e-36 125.3 53.9 2.4 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EGD97674.1 - 2.1e-14 52.9 22.0 3.5e-14 52.2 22.0 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Zn_clus PF00172.18 EGD97675.1 - 6.7e-05 22.9 8.6 0.00016 21.7 8.6 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EGD97675.1 - 0.0096 15.0 0.0 0.0096 15.0 0.0 2.6 4 0 0 4 4 4 1 Fungal specific transcription factor domain TFIIA PF03153.13 EGD97675.1 - 1.2 9.0 12.2 2.5 8.0 12.2 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Androgen_recep PF02166.16 EGD97675.1 - 2.3 6.9 11.3 3.6 6.3 11.3 1.2 1 0 0 1 1 1 0 Androgen receptor MFS_1 PF07690.16 EGD97677.1 - 6.7e-23 81.2 43.1 1.5e-21 76.7 42.8 2.8 1 1 0 1 1 1 1 Major Facilitator Superfamily UL42 PF17638.2 EGD97677.1 - 0.063 13.2 1.0 0.68 9.9 0.0 2.8 3 0 0 3 3 3 0 HCMV UL42 RHD3 PF05879.12 EGD97678.1 - 5.7e-300 996.8 0.0 2.4e-185 617.9 1.7 2.0 1 1 1 2 2 2 2 Root hair defective 3 GTP-binding protein (RHD3) GBP PF02263.19 EGD97678.1 - 2.7e-07 30.2 0.1 4.9e-07 29.3 0.1 1.4 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain Dynamin_N PF00350.23 EGD97678.1 - 9.4e-06 25.8 0.1 1.8e-05 24.8 0.1 1.5 1 0 0 1 1 1 1 Dynamin family AAA_28 PF13521.6 EGD97678.1 - 0.00011 22.4 0.0 0.0004 20.7 0.0 2.0 1 0 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.23 EGD97678.1 - 0.00012 22.2 0.1 0.00025 21.1 0.1 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase Septin PF00735.18 EGD97678.1 - 0.00059 19.2 0.2 0.0012 18.2 0.2 1.5 1 0 0 1 1 1 1 Septin DIM1 PF02966.16 EGD97679.1 - 2.2e-68 228.1 0.1 2.6e-68 227.9 0.1 1.0 1 0 0 1 1 1 1 Mitosis protein DIM1 Thioredoxin PF00085.20 EGD97679.1 - 0.0047 16.9 0.0 0.006 16.6 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin 4HBT_2 PF13279.6 EGD97680.1 - 2.8e-09 37.5 0.0 4.1e-09 37.0 0.0 1.3 1 0 0 1 1 1 1 Thioesterase-like superfamily HIG_1_N PF04588.13 EGD97681.1 - 2.8e-06 27.4 0.2 2.8e-06 27.4 0.2 1.9 3 0 0 3 3 3 1 Hypoxia induced protein conserved region Med26 PF08711.11 EGD97682.1 - 1.9e-09 37.4 0.0 4e-09 36.4 0.0 1.6 1 0 0 1 1 1 1 TFIIS helical bundle-like domain Tom5 PF10642.9 EGD97683.1 - 1e-18 67.0 0.1 1.1e-18 66.9 0.1 1.0 1 0 0 1 1 1 1 Mitochondrial import receptor subunit or translocase Nup54 PF13874.6 EGD97684.1 - 1.1e-41 142.2 0.3 1.1e-41 142.2 0.3 3.0 3 1 0 3 3 3 1 Nucleoporin complex subunit 54 Nup54_57_C PF18570.1 EGD97684.1 - 9.4e-13 47.5 1.3 1.6e-12 46.7 1.3 1.4 1 0 0 1 1 1 1 NUP57/Nup54 C-terminal domain Nucleoporin_FG PF13634.6 EGD97684.1 - 8.6e-09 36.1 36.0 8.6e-09 36.1 36.0 2.5 1 1 1 2 2 2 1 Nucleoporin FG repeat region Fib_alpha PF08702.10 EGD97684.1 - 0.0027 17.9 0.7 0.0027 17.9 0.7 2.1 2 0 0 2 2 2 1 Fibrinogen alpha/beta chain family AAA PF00004.29 EGD97685.1 - 5.1e-16 59.3 0.0 1.4e-15 57.9 0.0 1.8 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_10 PF17872.1 EGD97685.1 - 1.6e-12 47.4 1.0 9.6e-12 44.9 0.5 2.3 2 0 0 2 2 2 1 AAA lid domain AAA_16 PF13191.6 EGD97685.1 - 2.3e-12 47.6 0.0 1.8e-10 41.5 0.0 3.2 3 1 0 3 3 3 1 AAA ATPase domain AAA_22 PF13401.6 EGD97685.1 - 2.7e-09 37.4 0.0 1.1e-08 35.4 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 EGD97685.1 - 0.00073 19.9 0.0 0.0015 18.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 EGD97685.1 - 0.0011 18.9 1.4 0.0017 18.2 0.0 2.0 3 0 0 3 3 3 1 AAA domain AAA_28 PF13521.6 EGD97685.1 - 0.0015 18.8 0.0 0.0042 17.4 0.0 1.8 1 0 0 1 1 1 1 AAA domain KAP_NTPase PF07693.14 EGD97685.1 - 0.0051 16.1 0.0 0.015 14.5 0.0 1.7 2 0 0 2 2 2 1 KAP family P-loop domain NACHT PF05729.12 EGD97685.1 - 0.012 15.6 0.0 0.035 14.0 0.0 1.8 1 1 0 1 1 1 0 NACHT domain BAH PF01426.18 EGD97685.1 - 0.018 14.9 0.0 0.04 13.8 0.0 1.5 1 0 0 1 1 1 0 BAH domain RNA_helicase PF00910.22 EGD97685.1 - 0.018 15.4 0.0 0.098 13.1 0.0 2.3 2 0 0 2 2 1 0 RNA helicase ATPase_2 PF01637.18 EGD97685.1 - 0.021 14.8 0.0 0.3 10.9 0.0 2.2 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_33 PF13671.6 EGD97685.1 - 0.028 14.6 0.0 0.31 11.2 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_6 PF12774.7 EGD97685.1 - 0.029 13.4 0.0 0.047 12.6 0.0 1.2 1 0 0 1 1 1 0 Hydrolytic ATP binding site of dynein motor region AAA_7 PF12775.7 EGD97685.1 - 0.037 13.5 0.0 0.31 10.5 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region PIF1 PF05970.14 EGD97685.1 - 0.074 12.2 0.0 0.14 11.3 0.0 1.3 1 0 0 1 1 1 0 PIF1-like helicase DUF2075 PF09848.9 EGD97685.1 - 0.076 12.2 0.0 0.56 9.4 0.0 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) BLM_N PF16202.5 EGD97685.1 - 0.1 11.7 0.1 0.1 11.7 0.1 1.6 2 0 0 2 2 2 0 N-terminal region of Bloom syndrome protein S6OS1 PF15676.5 EGD97685.1 - 0.13 10.7 0.1 0.24 9.8 0.1 1.3 1 0 0 1 1 1 0 Six6 opposite strand transcript 1 family WD40 PF00400.32 EGD97686.1 - 3.5e-42 141.6 15.5 9.8e-10 38.9 0.2 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EGD97686.1 - 5.1e-05 23.5 0.7 1.7 9.0 0.0 4.6 1 1 3 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EGD97686.1 - 0.012 14.3 1.9 8.7 4.9 0.0 3.8 1 1 3 4 4 4 0 Nucleoporin Nup120/160 WD40_like PF17005.5 EGD97686.1 - 0.24 10.7 0.0 1.1 8.5 0.0 2.0 2 0 0 2 2 2 0 WD40-like domain Ank_2 PF12796.7 EGD97687.1 - 1.3e-41 141.0 1.2 1.8e-14 54.1 0.1 3.6 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EGD97687.1 - 4.7e-33 112.8 2.4 4e-09 36.6 0.0 4.6 2 2 3 5 5 5 4 Ankyrin repeats (many copies) Ank_4 PF13637.6 EGD97687.1 - 4.9e-33 113.1 1.9 3.2e-09 37.1 0.0 4.9 2 2 4 6 6 6 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EGD97687.1 - 1.9e-27 92.2 0.3 0.00069 19.9 0.0 6.2 6 0 0 6 6 6 6 Ankyrin repeat Ank PF00023.30 EGD97687.1 - 2.2e-20 72.1 0.9 0.0025 18.2 0.0 5.9 6 0 0 6 6 6 5 Ankyrin repeat TMF_TATA_bd PF12325.8 EGD97688.1 - 5e-40 136.3 13.4 5e-40 136.3 13.4 7.4 3 1 3 7 7 7 3 TATA element modulatory factor 1 TATA binding TMF_DNA_bd PF12329.8 EGD97688.1 - 6.4e-23 80.5 19.0 6.4e-23 80.5 19.0 8.3 5 3 2 7 7 7 1 TATA element modulatory factor 1 DNA binding ATG16 PF08614.11 EGD97688.1 - 8.1e-05 22.9 3.9 8.1e-05 22.9 3.9 6.0 2 1 3 6 6 6 1 Autophagy protein 16 (ATG16) FH2 PF02181.23 EGD97688.1 - 0.0053 15.9 1.9 0.0053 15.9 1.9 5.0 3 2 2 5 5 5 1 Formin Homology 2 Domain Muted PF14942.6 EGD97688.1 - 0.013 15.9 6.5 0.013 15.9 6.5 6.1 2 1 4 7 7 7 0 Organelle biogenesis, Muted-like protein V-ATPase_H_N PF03224.14 EGD97690.1 - 5.5e-81 272.3 0.0 8.3e-81 271.7 0.0 1.3 1 0 0 1 1 1 1 V-ATPase subunit H V-ATPase_H_C PF11698.8 EGD97690.1 - 1.6e-35 121.8 0.0 5.6e-35 120.0 0.0 2.0 1 0 0 1 1 1 1 V-ATPase subunit H DUF3842 PF12953.7 EGD97690.1 - 0.11 12.9 0.0 3.2 8.1 0.0 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF3842) APH PF01636.23 EGD97692.1 - 2.4e-09 37.5 0.9 4.1e-09 36.7 0.2 1.7 2 0 0 2 2 2 1 Phosphotransferase enzyme family HNH_2 PF13391.6 EGD97693.1 - 2.9e-09 36.9 0.2 8.8e-09 35.4 0.1 1.9 2 0 0 2 2 2 1 HNH endonuclease EH_Signature PF15611.6 EGD97693.1 - 0.097 12.1 0.0 0.37 10.1 0.0 1.7 1 1 0 1 1 1 0 EH_Signature domain HSDR_N PF04313.14 EGD97696.1 - 0.047 13.6 0.0 0.076 13.0 0.0 1.3 1 0 0 1 1 1 0 Type I restriction enzyme R protein N terminus (HSDR_N) F-box PF00646.33 EGD97697.1 - 0.0032 17.3 0.0 0.0056 16.5 0.0 1.4 1 0 0 1 1 1 1 F-box domain His_Phos_1 PF00300.22 EGD97699.1 - 0.00025 20.8 1.3 1.9 8.1 0.0 4.0 4 0 0 4 4 4 3 Histidine phosphatase superfamily (branch 1) Peptidase_M35 PF02102.15 EGD97700.1 - 1.2e-89 300.7 12.5 1.4e-51 175.5 6.3 2.0 1 1 1 2 2 2 2 Deuterolysin metalloprotease (M35) family Aspzincin_M35 PF14521.6 EGD97700.1 - 3.3e-39 134.7 1.1 6.2e-39 133.8 1.1 1.4 1 0 0 1 1 1 1 Lysine-specific metallo-endopeptidase HRXXH PF13933.6 EGD97700.1 - 0.006 16.2 1.1 0.018 14.6 1.1 1.9 1 1 0 1 1 1 1 Putative peptidase family UPF0160 PF03690.13 EGD97703.1 - 5.2e-124 414.0 0.0 5.9e-124 413.8 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0160) Trimer_CC PF08954.11 EGD97703.1 - 0.0089 15.6 0.1 0.42 10.2 0.0 2.4 2 0 0 2 2 2 1 Trimerisation motif 5_nucleotid_C PF02872.18 EGD97705.1 - 5.6e-38 130.6 0.0 9e-38 130.0 0.0 1.3 1 0 0 1 1 1 1 5'-nucleotidase, C-terminal domain Metallophos PF00149.28 EGD97705.1 - 1.2e-06 29.2 0.0 2e-06 28.4 0.0 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Peptidase_C1_2 PF03051.15 EGD97707.1 - 7.9e-136 453.3 0.0 9.9e-136 453.0 0.0 1.0 1 0 0 1 1 1 1 Peptidase C1-like family Peptidase_C1 PF00112.23 EGD97707.1 - 1.4e-05 25.3 0.0 3.7e-05 23.9 0.0 1.8 2 0 0 2 2 2 1 Papain family cysteine protease Kinesin PF00225.23 EGD97708.1 - 2e-112 375.4 0.4 5.9e-112 373.9 0.4 1.8 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EGD97708.1 - 2.2e-25 89.3 0.0 9.7e-25 87.3 0.0 2.1 1 0 0 1 1 1 1 Microtubule binding DUF1398 PF07166.11 EGD97708.1 - 0.039 14.0 0.2 0.14 12.3 0.2 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1398) POTRA_2 PF08479.11 EGD97708.1 - 0.11 12.3 0.8 0.96 9.3 0.1 2.7 2 0 0 2 2 2 0 POTRA domain, ShlB-type LEA_6 PF10714.9 EGD97708.1 - 0.32 11.1 1.4 0.83 9.8 1.4 1.6 1 0 0 1 1 1 0 Late embryogenesis abundant protein 18 Nbl1_Borealin_N PF10444.9 EGD97708.1 - 5.1 6.8 11.7 0.81 9.4 0.4 4.5 3 1 0 3 3 3 0 Nbl1 / Borealin N terminal Thiolase_N PF00108.23 EGD97709.1 - 2.1e-92 309.1 1.4 2.8e-92 308.8 1.4 1.1 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 EGD97709.1 - 3.2e-37 126.9 0.7 3.2e-37 126.9 0.7 1.8 2 0 0 2 2 2 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 EGD97709.1 - 9.2e-05 22.1 0.4 0.00021 20.9 0.4 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III PF08545.10 EGD97709.1 - 0.027 14.3 3.4 2.4 8.0 0.0 3.1 3 0 0 3 3 3 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Asp_protease_2 PF13650.6 EGD97710.1 - 0.083 13.5 0.3 0.16 12.7 0.2 1.5 1 1 0 1 1 1 0 Aspartyl protease Helicase_C PF00271.31 EGD97711.1 - 5.9e-10 39.5 0.0 1e-09 38.7 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain UQ_con PF00179.26 EGD97713.1 - 1.3e-51 173.9 0.0 1.5e-51 173.8 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EGD97713.1 - 0.0007 19.3 0.0 0.00078 19.1 0.0 1.1 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 EGD97713.1 - 0.083 13.2 0.0 0.11 12.7 0.0 1.4 1 1 0 1 1 1 0 RWD domain Cation_efflux PF01545.21 EGD97714.1 - 3e-46 157.7 15.3 3e-46 157.7 15.3 2.8 2 0 0 2 2 2 1 Cation efflux family AveC_like PF17198.4 EGD97714.1 - 0.0018 17.8 0.1 0.0056 16.1 0.1 1.9 1 0 0 1 1 1 1 Spirocyclase AveC-like Glyco_trans_4_4 PF13579.6 EGD97715.1 - 8.2e-10 39.3 0.6 1.3e-09 38.7 0.6 1.3 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_transf_4 PF13439.6 EGD97715.1 - 3.4e-07 30.4 1.5 5.4e-07 29.8 1.5 1.4 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_1_4 PF13692.6 EGD97715.1 - 3.5e-06 27.5 0.0 2.6e-05 24.7 0.0 2.3 3 0 0 3 3 3 1 Glycosyl transferases group 1 Glycos_transf_1 PF00534.20 EGD97715.1 - 0.0014 18.2 0.0 0.011 15.2 0.0 2.1 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.6 EGD97715.1 - 0.032 14.6 0.0 0.066 13.6 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferases group 1 TFIIIC_delta PF12657.7 EGD97716.1 - 5.2e-43 147.1 0.1 1.5e-42 145.7 0.1 1.8 1 0 0 1 1 1 1 Transcription factor IIIC subunit delta N-term zf-TFIIIC PF12660.7 EGD97716.1 - 1.3e-29 102.2 2.1 2.7e-29 101.1 2.1 1.5 1 0 0 1 1 1 1 Putative zinc-finger of transcription factor IIIC complex Mito_carr PF00153.27 EGD97717.1 - 4.5e-58 193.2 4.6 6.9e-19 67.6 0.4 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein LtrA PF06772.11 EGD97718.1 - 4e-20 72.3 19.4 4e-20 72.3 19.4 2.1 2 0 0 2 2 2 2 Bacterial low temperature requirement A protein (LtrA) DUF2976 PF11190.8 EGD97718.1 - 0.013 15.3 0.5 0.013 15.3 0.5 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF2976) DUF4212 PF13937.6 EGD97718.1 - 0.89 10.0 10.8 0.54 10.7 0.2 3.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4212) HNH_2 PF13391.6 EGD97719.1 - 1.1e-15 57.5 0.1 2.4e-15 56.4 0.1 1.6 1 0 0 1 1 1 1 HNH endonuclease Ribosomal_L16 PF00252.18 EGD97720.1 - 6.6e-16 58.5 0.0 9.2e-16 58.1 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e AA_permease PF00324.21 EGD97721.1 - 5.3e-61 206.7 28.0 2.7e-60 204.3 28.0 1.9 1 1 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EGD97721.1 - 1.3e-21 77.0 22.0 2.5e-21 76.0 21.9 1.5 1 1 0 1 1 1 1 Amino acid permease TspO_MBR PF03073.15 EGD97721.1 - 2.2 8.3 11.2 0.24 11.4 5.6 2.4 2 1 0 2 2 2 0 TspO/MBR family UQ_con PF00179.26 EGD97723.1 - 1.8e-44 150.8 0.0 2e-44 150.7 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EGD97723.1 - 0.14 11.9 0.1 0.24 11.1 0.1 1.6 1 1 0 1 1 1 0 Prokaryotic E2 family B RWD PF05773.22 EGD97723.1 - 0.32 11.3 2.3 0.42 10.9 2.3 1.6 1 1 0 1 1 1 0 RWD domain CFEM PF05730.11 EGD97724.1 - 7.2e-13 48.4 5.8 1e-12 47.9 5.8 1.2 1 0 0 1 1 1 1 CFEM domain APH PF01636.23 EGD97726.1 - 6e-15 55.8 0.0 1.4e-14 54.6 0.0 1.6 1 1 0 1 1 1 1 Phosphotransferase enzyme family DUF1679 PF07914.11 EGD97726.1 - 0.0021 17.0 0.0 0.049 12.5 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF1679) Kdo PF06293.14 EGD97726.1 - 0.098 12.0 0.1 10 5.4 0.0 3.1 4 0 0 4 4 4 0 Lipopolysaccharide kinase (Kdo/WaaP) family Amidoligase_2 PF12224.8 EGD97727.1 - 8.2e-13 48.6 0.0 4.9e-12 46.1 0.0 2.1 1 1 0 1 1 1 1 Putative amidoligase enzyme MFS_1 PF07690.16 EGD97729.1 - 1.8e-11 43.6 39.1 1.8e-11 43.6 39.1 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily UNC-93 PF05978.16 EGD97729.1 - 5.9e-08 32.6 7.2 5.9e-08 32.6 7.2 3.0 3 1 0 3 3 3 1 Ion channel regulatory protein UNC-93 Sas10_Utp3 PF04000.15 EGD97730.1 - 1e-17 64.5 1.4 1e-17 64.5 1.4 2.4 2 1 1 3 3 3 1 Sas10/Utp3/C1D family Glypican PF01153.19 EGD97730.1 - 0.7 8.7 4.7 1.1 8.0 4.7 1.2 1 0 0 1 1 1 0 Glypican CENP-B_dimeris PF09026.10 EGD97730.1 - 1 9.8 14.1 2.4 8.6 14.1 1.6 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DUF4746 PF15928.5 EGD97730.1 - 2.5 7.4 12.3 9.1 5.6 12.4 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4746) RRN3 PF05327.11 EGD97730.1 - 2.6 6.5 6.8 3.5 6.1 6.8 1.3 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 DNA_pol_phi PF04931.13 EGD97730.1 - 2.8 5.9 26.1 0.49 8.4 22.2 1.6 2 0 0 2 2 2 0 DNA polymerase phi NOA36 PF06524.12 EGD97730.1 - 6.1 6.1 14.9 14 4.9 14.9 1.5 1 0 0 1 1 1 0 NOA36 protein FMO-like PF00743.19 EGD97732.1 - 1.5e-13 50.0 0.0 9.4e-13 47.4 0.0 2.0 1 1 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 EGD97732.1 - 5.6e-13 48.8 0.0 2.5e-09 36.8 0.0 2.9 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EGD97732.1 - 1.1e-11 44.5 0.0 5.6e-11 42.2 0.0 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EGD97732.1 - 1.7e-09 37.3 0.0 4.4e-07 29.4 0.0 2.8 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 EGD97732.1 - 7.4e-07 29.3 1.1 2.6e-05 24.3 0.0 3.0 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 EGD97732.1 - 1.7e-06 28.4 1.8 0.042 14.4 0.2 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 EGD97732.1 - 5.3e-06 25.9 0.1 0.0051 16.1 0.0 2.2 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_9 PF13454.6 EGD97732.1 - 0.00049 20.1 0.9 0.068 13.2 0.0 3.3 4 0 0 4 4 4 1 FAD-NAD(P)-binding DAO PF01266.24 EGD97732.1 - 0.0015 18.2 1.3 0.01 15.5 0.5 2.5 2 1 0 3 3 3 1 FAD dependent oxidoreductase NAD_binding_7 PF13241.6 EGD97732.1 - 0.0065 16.9 0.0 0.078 13.4 0.0 2.3 2 0 0 2 2 2 1 Putative NAD(P)-binding 3HCDH_N PF02737.18 EGD97732.1 - 0.0086 16.0 0.3 0.017 15.1 0.2 1.4 1 1 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Shikimate_DH PF01488.20 EGD97732.1 - 0.015 15.4 0.1 5.2 7.1 0.0 2.7 3 0 0 3 3 3 0 Shikimate / quinate 5-dehydrogenase FAD_binding_2 PF00890.24 EGD97732.1 - 0.028 13.5 0.2 0.028 13.5 0.2 1.5 2 0 0 2 2 2 0 FAD binding domain HI0933_like PF03486.14 EGD97732.1 - 0.35 9.5 1.4 1.2 7.8 0.1 2.3 3 0 0 3 3 3 0 HI0933-like protein FAD_oxidored PF12831.7 EGD97732.1 - 0.62 9.3 1.6 1.4 8.1 0.0 2.0 2 0 0 2 2 2 0 FAD dependent oxidoreductase GIDA PF01134.22 EGD97732.1 - 8.9 5.3 6.2 1 8.4 0.1 2.1 2 0 0 2 2 2 0 Glucose inhibited division protein A NmrA PF05368.13 EGD97733.1 - 4.8e-07 29.6 0.0 5.9e-07 29.3 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family Med3 PF11593.8 EGD97735.1 - 5.1 6.2 7.8 7 5.7 7.8 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal MFS_1 PF07690.16 EGD97737.1 - 5.9e-35 120.8 50.2 5.9e-35 120.8 50.2 2.1 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EGD97737.1 - 1.7e-20 73.0 13.7 2.2e-20 72.6 13.7 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 EGD97737.1 - 9.6e-13 47.8 10.1 9.6e-13 47.8 10.1 2.5 3 0 0 3 3 3 1 Sugar (and other) transporter OATP PF03137.20 EGD97737.1 - 0.76 8.0 10.5 2 6.6 5.2 2.4 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family Pkinase_fungal PF17667.1 EGD97738.1 - 1.9e-98 329.9 0.0 3e-96 322.7 0.0 2.1 1 1 1 2 2 2 2 Fungal protein kinase Pkinase PF00069.25 EGD97738.1 - 5.8e-07 29.1 0.0 1e-06 28.3 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD97738.1 - 0.0078 15.5 0.0 0.015 14.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.22 EGD97738.1 - 0.0093 15.6 0.0 0.025 14.2 0.0 1.7 1 0 0 1 1 1 1 RIO1 family EMP70 PF02990.16 EGD97739.1 - 1.5e-193 644.2 4.1 1.9e-193 643.8 4.1 1.1 1 0 0 1 1 1 1 Endomembrane protein 70 APH PF01636.23 EGD97740.1 - 1.1e-10 41.9 0.0 2.4e-10 40.7 0.0 1.4 1 1 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.20 EGD97740.1 - 0.00043 19.7 0.0 0.00087 18.7 0.0 1.4 1 0 0 1 1 1 1 Ecdysteroid kinase DUF1679 PF07914.11 EGD97740.1 - 0.011 14.7 0.0 0.018 14.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1679) Choline_kinase PF01633.20 EGD97740.1 - 0.026 14.1 0.0 0.04 13.5 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase EF-hand_1 PF00036.32 EGD97741.1 - 2.3e-26 89.3 9.6 2.7e-08 32.8 0.1 4.8 5 0 0 5 5 5 4 EF hand EF-hand_6 PF13405.6 EGD97741.1 - 1.5e-25 86.9 2.7 3e-06 26.7 0.1 5.2 5 0 0 5 5 5 4 EF-hand domain EF-hand_7 PF13499.6 EGD97741.1 - 1.7e-24 86.0 6.0 8.6e-16 58.2 0.6 3.0 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 EGD97741.1 - 1.1e-17 62.6 14.6 1.9e-05 24.0 0.0 4.8 6 0 0 6 6 6 4 EF hand EF-hand_8 PF13833.6 EGD97741.1 - 3.2e-16 58.9 9.9 3.2e-06 26.9 0.9 4.2 2 2 1 3 3 3 3 EF-hand domain pair EF-hand_4 PF12763.7 EGD97741.1 - 4.2e-09 36.3 4.6 0.001 19.0 0.1 3.7 1 1 3 4 4 4 3 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 EGD97741.1 - 8.7e-05 22.8 0.4 0.14 12.5 0.0 3.4 2 1 1 3 3 3 2 EF-hand domain SPARC_Ca_bdg PF10591.9 EGD97741.1 - 0.0033 17.7 0.9 0.52 10.7 0.2 3.1 2 2 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region DUF1679 PF07914.11 EGD97741.1 - 0.016 14.1 0.5 1.2 7.9 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1679) EF-hand_10 PF14788.6 EGD97741.1 - 0.033 14.1 2.3 1.3 9.0 0.1 3.6 4 1 0 4 4 4 0 EF hand Med4 PF10018.9 EGD97742.1 - 1.8e-34 119.1 0.1 4.6e-34 117.8 0.1 1.6 1 1 0 1 1 1 1 Vitamin-D-receptor interacting Mediator subunit 4 DNA_pol_phi PF04931.13 EGD97742.1 - 0.61 8.1 2.1 0.85 7.6 2.1 1.3 1 0 0 1 1 1 0 DNA polymerase phi MFS_1 PF07690.16 EGD97743.1 - 1.5e-27 96.5 36.5 2.3e-27 95.9 35.7 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EGD97743.1 - 0.0011 17.5 2.9 0.0014 17.1 2.9 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) EGF_2 PF07974.13 EGD97744.1 - 0.92 9.9 10.5 1.2 9.5 10.5 1.2 1 0 0 1 1 1 0 EGF-like domain RabGAP-TBC PF00566.18 EGD97745.1 - 2e-49 168.1 0.6 1e-48 165.9 0.0 2.5 2 1 2 4 4 4 1 Rab-GTPase-TBC domain DUF1664 PF07889.12 EGD97745.1 - 0.2 11.7 9.5 0.022 14.8 2.7 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) DUF2570 PF10828.8 EGD97745.1 - 2.7 7.9 14.2 0.96 9.3 2.7 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2570) ADIP PF11559.8 EGD97745.1 - 6.6 6.8 28.9 0.58 10.2 11.2 2.8 3 0 0 3 3 3 0 Afadin- and alpha -actinin-Binding APG6_N PF17675.1 EGD97745.1 - 9.3 6.8 32.4 0.63 10.6 5.9 4.3 4 0 0 4 4 4 0 Apg6 coiled-coil region Acyl-CoA_dh_1 PF00441.24 EGD97746.1 - 5.1e-30 104.7 1.9 9.4e-30 103.8 1.9 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 EGD97746.1 - 3.9e-23 82.3 0.1 8.9e-23 81.1 0.1 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 EGD97746.1 - 9.2e-16 57.8 0.0 1.6e-15 57.1 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 EGD97746.1 - 8.1e-15 55.3 3.3 1.4e-14 54.5 0.9 2.1 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Reticulon PF02453.17 EGD97747.1 - 2.2e-27 96.0 5.8 3e-27 95.5 5.8 1.2 1 0 0 1 1 1 1 Reticulon Pex24p PF06398.11 EGD97747.1 - 0.0067 15.5 4.7 0.011 14.8 3.7 1.5 1 1 1 2 2 2 2 Integral peroxisomal membrane peroxin SCAB_CC PF16712.5 EGD97747.1 - 0.097 12.5 0.3 0.15 11.9 0.3 1.2 1 0 0 1 1 1 0 Coiled-coil regions of plant-specific actin-binding protein Phasin_2 PF09361.10 EGD97747.1 - 0.11 12.7 1.5 0.24 11.7 0.4 2.0 2 0 0 2 2 2 0 Phasin protein CDC27 PF09507.10 EGD97747.1 - 0.14 11.5 6.6 0.2 11.0 6.6 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 DNA_topoisoIV PF00521.20 EGD97749.1 - 6.2e-135 450.4 0.1 1.4e-134 449.2 0.1 1.6 1 0 0 1 1 1 1 DNA gyrase/topoisomerase IV, subunit A TOPRIM_C PF16898.5 EGD97749.1 - 4.9e-52 175.6 6.9 4.9e-52 175.6 6.9 2.5 3 0 0 3 3 3 1 C-terminal associated domain of TOPRIM DNA_gyraseB PF00204.25 EGD97749.1 - 1e-25 90.2 2.7 1e-25 90.2 2.7 2.0 2 0 0 2 2 2 1 DNA gyrase B HATPase_c PF02518.26 EGD97749.1 - 4.9e-15 56.0 0.0 1.7e-14 54.3 0.0 1.9 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Toprim PF01751.22 EGD97749.1 - 5.5e-07 29.8 0.1 3.6e-06 27.1 0.0 2.6 2 0 0 2 2 2 1 Toprim domain Mitofilin PF09731.9 EGD97749.1 - 0.0009 18.2 11.1 0.0009 18.2 11.1 3.8 3 1 1 4 4 4 1 Mitochondrial inner membrane protein INCENP_ARK-bind PF03941.15 EGD97750.1 - 8.2e-17 60.9 0.9 2.7e-16 59.2 0.9 2.0 1 0 0 1 1 1 1 Inner centromere protein, ARK binding region PDZ_1 PF12812.7 EGD97751.1 - 4.8e-53 177.1 0.0 1.2e-34 118.1 0.0 3.3 3 0 0 3 3 3 2 PDZ-like domain PDZ_6 PF17820.1 EGD97751.1 - 1.6e-15 56.7 0.8 6e-07 29.2 0.6 4.6 4 0 0 4 4 4 3 PDZ domain PDZ_2 PF13180.6 EGD97751.1 - 2.8e-15 56.4 0.8 5.9e-06 26.5 0.0 4.5 5 0 0 5 5 5 3 PDZ domain Trypsin_2 PF13365.6 EGD97751.1 - 3.4e-13 50.7 1.6 7.9e-10 39.8 0.5 3.5 2 1 0 2 2 2 1 Trypsin-like peptidase domain PDZ PF00595.24 EGD97751.1 - 7.1e-10 39.1 0.0 0.00024 21.4 0.0 3.6 3 0 0 3 3 3 2 PDZ domain Tricorn_PDZ PF14685.6 EGD97751.1 - 0.001 19.0 0.3 0.39 10.7 0.2 3.9 4 0 0 4 4 4 1 Tricorn protease PDZ domain 4HPAD_g_N PF18671.1 EGD97751.1 - 0.058 13.1 0.0 0.19 11.5 0.0 1.9 1 0 0 1 1 1 0 4-Hydroxyphenylacetate decarboxylase subunit gamma N-terminal SSXT PF05030.12 EGD97752.1 - 1.8e-06 27.4 3.9 0.0049 16.5 0.0 2.7 3 0 0 3 3 3 2 SSXT protein (N-terminal region) K_channel_TID PF07941.11 EGD97752.1 - 2.9 8.4 11.9 0.38 11.3 2.9 2.8 2 1 0 2 2 2 0 Potassium channel Kv1.4 tandem inactivation domain ABC_membrane PF00664.23 EGD97754.1 - 5.9e-64 216.4 19.1 2.9e-48 164.9 10.5 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EGD97754.1 - 5.9e-50 169.3 0.0 2.8e-32 112.1 0.0 2.4 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EGD97754.1 - 7.9e-11 41.8 0.4 0.00047 19.6 0.1 3.5 3 0 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 EGD97754.1 - 5.2e-07 29.7 0.0 0.0047 16.7 0.0 3.0 3 0 0 3 3 3 2 AAA ATPase domain AAA_29 PF13555.6 EGD97754.1 - 5.8e-07 29.2 0.4 0.022 14.5 0.1 3.0 2 0 0 2 2 2 2 P-loop containing region of AAA domain FAD_binding_4 PF01565.23 EGD97754.1 - 9.8e-07 28.6 0.4 9.8e-07 28.6 0.4 2.6 3 0 0 3 3 2 1 FAD binding domain AAA_16 PF13191.6 EGD97754.1 - 9.9e-07 29.3 3.4 0.027 14.9 0.0 3.2 3 1 0 3 3 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 EGD97754.1 - 2.1e-06 27.7 0.1 0.033 14.1 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase AAA_21 PF13304.6 EGD97754.1 - 2.5e-06 27.5 0.6 0.014 15.2 0.0 3.2 2 1 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 EGD97754.1 - 3e-06 27.5 2.4 0.019 15.2 0.0 3.9 3 1 0 3 3 3 2 AAA domain AAA_30 PF13604.6 EGD97754.1 - 4.2e-06 26.6 1.3 0.25 11.0 1.5 3.7 2 1 0 2 2 2 2 AAA domain DUF87 PF01935.17 EGD97754.1 - 1.8e-05 25.0 0.0 0.0065 16.6 0.0 2.8 3 0 0 3 3 2 1 Helicase HerA, central domain AAA_23 PF13476.6 EGD97754.1 - 0.0001 22.9 0.2 0.16 12.4 0.3 2.4 2 0 0 2 2 2 2 AAA domain AAA_5 PF07728.14 EGD97754.1 - 0.00057 19.9 0.0 0.53 10.3 0.0 3.1 3 0 0 3 3 3 1 AAA domain (dynein-related subfamily) Zeta_toxin PF06414.12 EGD97754.1 - 0.0007 18.9 0.1 1.1 8.5 0.0 3.2 3 0 0 3 3 3 1 Zeta toxin AAA PF00004.29 EGD97754.1 - 0.00075 19.9 1.9 4.2 7.8 1.0 3.4 2 1 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) ABC_ATPase PF09818.9 EGD97754.1 - 0.0033 16.3 0.1 0.0087 14.9 0.1 1.7 1 0 0 1 1 1 1 Predicted ATPase of the ABC class AAA_25 PF13481.6 EGD97754.1 - 0.004 16.8 1.4 3 7.4 0.0 3.2 3 0 0 3 3 3 2 AAA domain AAA_33 PF13671.6 EGD97754.1 - 0.004 17.3 0.0 2.8 8.1 0.0 2.9 2 0 0 2 2 2 1 AAA domain AAA_7 PF12775.7 EGD97754.1 - 0.0042 16.6 0.1 2.4 7.6 0.0 2.4 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA_18 PF13238.6 EGD97754.1 - 0.0053 17.3 0.0 0.73 10.4 0.0 2.6 2 0 0 2 2 2 1 AAA domain Rad17 PF03215.15 EGD97754.1 - 0.0096 15.9 0.1 0.059 13.3 0.0 2.1 2 0 0 2 2 2 1 Rad17 P-loop domain PRK PF00485.18 EGD97754.1 - 0.021 14.6 0.3 0.085 12.6 0.0 2.0 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family AAA_24 PF13479.6 EGD97754.1 - 0.036 13.8 0.2 0.98 9.1 0.0 2.3 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 EGD97754.1 - 0.094 12.8 0.5 9.4 6.4 0.0 2.8 2 0 0 2 2 2 0 50S ribosome-binding GTPase RNA_helicase PF00910.22 EGD97754.1 - 0.1 13.0 0.1 4 7.9 0.0 2.5 2 0 0 2 2 2 0 RNA helicase Imm5 PF14423.6 EGD97754.1 - 0.14 12.4 0.1 1.2 9.3 0.1 2.3 2 0 0 2 2 2 0 Immunity protein Imm5 AAA_28 PF13521.6 EGD97754.1 - 0.15 12.3 0.2 1.4 9.1 0.0 2.3 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.22 EGD97754.1 - 0.16 11.1 0.1 1.7 7.8 0.0 2.2 2 0 0 2 2 2 0 NB-ARC domain Pkinase_fungal PF17667.1 EGD97755.1 - 3.4e-132 441.1 0.0 4.6e-132 440.7 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Pkinase PF00069.25 EGD97755.1 - 0.0002 20.9 0.0 0.00032 20.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain p450 PF00067.22 EGD97757.1 - 1.9e-30 106.0 0.0 2.2e-30 105.8 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 TnpW PF14202.6 EGD97757.1 - 0.17 11.7 2.4 53 3.8 0.0 3.4 3 0 0 3 3 3 0 Transposon-encoded protein TnpW Fungal_trans PF04082.18 EGD97758.1 - 1.6e-15 56.9 0.5 2.5e-15 56.2 0.5 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EGD97758.1 - 7e-06 26.1 10.2 1.6e-05 24.9 10.2 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain TPR_1 PF00515.28 EGD97759.1 - 8.6e-07 28.5 3.4 0.12 12.2 0.0 3.8 4 0 0 4 4 4 3 Tetratricopeptide repeat DUF3808 PF10300.9 EGD97759.1 - 0.00027 19.8 0.3 0.00038 19.3 0.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3808) TPR_2 PF07719.17 EGD97759.1 - 0.0032 17.5 5.0 0.27 11.4 0.0 3.9 3 1 0 3 3 3 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EGD97759.1 - 0.16 12.2 4.1 0.071 13.3 1.4 1.8 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 peroxidase PF00141.23 EGD97761.1 - 1.1e-45 156.1 0.0 1.6e-45 155.6 0.0 1.2 1 0 0 1 1 1 1 Peroxidase DUF4003 PF13170.6 EGD97761.1 - 0.17 11.2 0.0 0.3 10.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4003) COesterase PF00135.28 EGD97763.1 - 8.9e-61 206.3 0.0 1.1e-60 205.9 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EGD97763.1 - 0.0013 18.7 0.0 0.0078 16.1 0.0 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Fungal_trans_2 PF11951.8 EGD97764.1 - 3.8e-06 26.0 0.6 6.4e-06 25.2 0.6 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Pyridoxal_deC PF00282.19 EGD97765.1 - 5.2e-79 265.7 0.0 6.6e-79 265.3 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.19 EGD97765.1 - 4e-05 22.7 0.0 6.1e-05 22.1 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V OKR_DC_1 PF01276.20 EGD97765.1 - 0.027 13.2 0.0 0.039 12.7 0.0 1.2 1 0 0 1 1 1 0 Orn/Lys/Arg decarboxylase, major domain DegT_DnrJ_EryC1 PF01041.17 EGD97765.1 - 0.14 11.4 0.0 0.33 10.2 0.0 1.5 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family Peptidase_S8 PF00082.22 EGD97766.1 - 3.6e-32 111.8 8.8 1.2e-31 110.1 6.5 1.9 1 1 0 2 2 2 1 Subtilase family Inhibitor_I9 PF05922.16 EGD97766.1 - 4.8e-11 43.2 0.0 9.7e-11 42.2 0.0 1.5 1 0 0 1 1 1 1 Peptidase inhibitor I9 DUF3043 PF11241.8 EGD97768.1 - 0.34 10.9 11.9 0.98 9.4 11.9 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3043) FAM176 PF14851.6 EGD97768.1 - 1.6 8.4 5.4 5.8 6.6 5.4 1.9 1 0 0 1 1 1 0 FAM176 family MCM_bind PF09739.9 EGD97768.1 - 2.2 6.6 5.3 4.1 5.7 5.3 1.4 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor Rsm1 PF08600.10 EGD97770.1 - 1.1 9.5 5.2 2.9 8.1 5.2 1.7 1 0 0 1 1 1 0 Rsm1-like MgsA_C PF12002.8 EGD97770.1 - 9.5 6.1 7.5 18 5.2 7.5 1.4 1 0 0 1 1 1 0 MgsA AAA+ ATPase C terminal SBDS_C PF09377.10 EGD97771.1 - 2e-34 118.1 0.0 8.6e-34 116.0 0.0 1.9 1 1 0 1 1 1 1 SBDS protein C-terminal domain SBDS PF01172.18 EGD97771.1 - 6.7e-33 112.6 0.1 1.3e-32 111.7 0.1 1.5 1 0 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein Tox-REase-9 PF15650.6 EGD97771.1 - 0.064 13.5 0.1 0.16 12.2 0.1 1.7 1 0 0 1 1 1 0 Restriction endonuclease fold toxin 9 FAM176 PF14851.6 EGD97771.1 - 0.47 10.1 4.9 5.8 6.6 0.5 2.9 3 0 0 3 3 3 0 FAM176 family NST1 PF13945.6 EGD97771.1 - 0.59 10.2 10.3 2.3 8.3 1.2 3.1 3 0 0 3 3 3 0 Salt tolerance down-regulator Peptidase_S10 PF00450.22 EGD97772.1 - 5.7e-131 437.8 0.1 6.6e-131 437.6 0.1 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase Carbpep_Y_N PF05388.11 EGD97772.1 - 1.7e-06 28.6 0.4 8e-06 26.4 0.4 2.1 1 1 0 1 1 1 1 Carboxypeptidase Y pro-peptide Ribosomal_S13 PF00416.22 EGD97773.1 - 5e-56 188.6 4.2 5.8e-56 188.4 4.2 1.0 1 0 0 1 1 1 1 Ribosomal protein S13/S18 FbpA PF05833.11 EGD97773.1 - 0.016 14.0 0.0 0.018 13.8 0.0 1.2 1 0 0 1 1 1 0 Fibronectin-binding protein A N-terminus (FbpA) HHH_6 PF14579.6 EGD97773.1 - 0.038 14.2 0.1 0.23 11.8 0.0 2.2 1 1 1 2 2 2 0 Helix-hairpin-helix motif DUF1822 PF08852.11 EGD97773.1 - 0.11 11.5 0.0 0.14 11.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1822) LysM PF01476.20 EGD97775.1 - 1.9e-15 56.6 0.0 3.3e-06 27.1 0.0 2.6 2 0 0 2 2 2 2 LysM domain MAGI_u5 PF16666.5 EGD97775.1 - 1.3 9.2 5.9 0.19 11.9 1.5 1.9 2 0 0 2 2 2 0 Unstructured region on MAGI Cation_efflux PF01545.21 EGD97777.1 - 1.2e-30 106.8 7.9 2.8e-30 105.6 7.9 1.6 1 1 0 1 1 1 1 Cation efflux family MARVEL PF01284.23 EGD97777.1 - 0.00017 21.6 0.0 0.096 12.7 0.0 2.5 1 1 1 2 2 2 2 Membrane-associating domain EphA2_TM PF14575.6 EGD97777.1 - 0.15 12.9 1.3 8.3 7.4 0.0 3.1 3 1 1 4 4 4 0 Ephrin type-A receptor 2 transmembrane domain zf-MYND PF01753.18 EGD97778.1 - 5.5e-06 26.4 8.0 1e-05 25.5 8.0 1.4 1 0 0 1 1 1 1 MYND finger zf-HIT PF04438.16 EGD97778.1 - 1.8 8.5 5.4 3.1 7.7 5.4 1.4 1 0 0 1 1 1 0 HIT zinc finger Cyclin PF08613.11 EGD97780.1 - 3e-06 27.7 1.8 6.2e-06 26.7 0.0 2.3 2 0 0 2 2 2 1 Cyclin Cyclin_N PF00134.23 EGD97780.1 - 0.0021 17.8 0.0 0.0048 16.6 0.0 1.6 1 0 0 1 1 1 1 Cyclin, N-terminal domain Aminotran_4 PF01063.19 EGD97781.1 - 1.6e-23 83.8 0.0 1.9e-23 83.5 0.0 1.1 1 0 0 1 1 1 1 Amino-transferase class IV Sugar_tr PF00083.24 EGD97782.1 - 1.9e-85 287.4 19.3 2.3e-85 287.2 19.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EGD97782.1 - 3.9e-14 52.3 41.5 1.7e-11 43.7 22.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Radial_spoke PF04712.12 EGD97784.1 - 0.043 12.8 0.3 0.044 12.7 0.3 1.0 1 0 0 1 1 1 0 Radial spokehead-like protein CDC14 PF08045.11 EGD97785.1 - 3.7e-131 436.4 0.0 4.2e-131 436.2 0.0 1.0 1 0 0 1 1 1 1 Cell division control protein 14, SIN component TOH_N PF12549.8 EGD97785.1 - 0.057 13.3 3.6 0.19 11.6 3.6 1.9 1 0 0 1 1 1 0 Tyrosine hydroxylase N terminal Methyltransf_25 PF13649.6 EGD97786.1 - 7.9e-16 58.6 0.0 1.6e-15 57.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EGD97786.1 - 2.7e-15 56.8 0.0 4.8e-15 56.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EGD97786.1 - 1.5e-13 50.8 0.0 1.9e-13 50.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EGD97786.1 - 8.5e-13 48.9 0.0 1.4e-12 48.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EGD97786.1 - 1.5e-12 47.7 0.0 2.2e-12 47.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EGD97786.1 - 1.5e-05 24.4 0.0 4.1e-05 23.0 0.0 1.7 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family CMAS PF02353.20 EGD97786.1 - 4.2e-05 23.0 0.0 5.2e-05 22.7 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase MTS PF05175.14 EGD97786.1 - 6.2e-05 22.6 0.0 0.00045 19.8 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase small domain ADH_zinc_N PF00107.26 EGD97786.1 - 0.00084 19.3 0.0 0.0033 17.4 0.0 2.0 1 1 0 1 1 1 1 Zinc-binding dehydrogenase PCMT PF01135.19 EGD97786.1 - 0.0049 16.6 0.0 0.0062 16.3 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_4 PF02390.17 EGD97786.1 - 0.011 15.2 0.0 0.029 13.9 0.0 1.6 2 0 0 2 2 2 0 Putative methyltransferase Pox_MCEL PF03291.16 EGD97786.1 - 0.013 14.6 0.0 0.25 10.4 0.0 2.1 2 0 0 2 2 2 0 mRNA capping enzyme TehB PF03848.14 EGD97786.1 - 0.014 14.9 0.0 0.02 14.3 0.0 1.3 1 0 0 1 1 1 0 Tellurite resistance protein TehB Methyltransf_32 PF13679.6 EGD97786.1 - 0.03 14.3 0.0 0.048 13.7 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain VBS PF08913.10 EGD97786.1 - 0.043 14.3 0.0 0.18 12.2 0.0 2.0 2 1 0 2 2 2 0 Vinculin Binding Site Methyltransf_7 PF03492.15 EGD97786.1 - 0.053 12.7 0.0 0.096 11.9 0.0 1.3 1 0 0 1 1 1 0 SAM dependent carboxyl methyltransferase DOT1 PF08123.13 EGD97786.1 - 0.1 12.1 0.0 0.16 11.5 0.0 1.3 1 0 0 1 1 1 0 Histone methylation protein DOT1 Methyltransf_8 PF05148.15 EGD97786.1 - 0.2 11.5 0.0 0.7 9.7 0.0 1.8 1 1 0 1 1 1 0 Hypothetical methyltransferase GST_C_6 PF17171.4 EGD97787.1 - 6.9e-20 70.6 0.1 1.3e-19 69.7 0.1 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_4 PF17172.4 EGD97787.1 - 3.4e-19 69.4 0.0 7.7e-19 68.3 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase N-terminal domain Tom37 PF10568.9 EGD97787.1 - 2.8e-11 43.8 0.0 8.5e-11 42.2 0.0 1.8 1 1 0 1 1 1 1 Outer mitochondrial membrane transport complex protein SAM35 PF10806.8 EGD97787.1 - 4.3e-06 27.0 0.0 1.4e-05 25.4 0.0 1.8 2 0 0 2 2 2 1 SAM35, subunit of SAM coomplex GST_C_2 PF13410.6 EGD97787.1 - 0.033 14.2 0.0 0.068 13.2 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Copper-fist PF00649.18 EGD97788.1 - 1.2e-17 63.1 0.4 1.2e-17 63.1 0.4 2.0 2 0 0 2 2 2 1 Copper fist DNA binding domain DUF4805 PF16063.5 EGD97788.1 - 0.0067 15.8 6.1 0.02 14.3 6.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4805) SUIM_assoc PF16619.5 EGD97788.1 - 0.022 14.8 6.3 0.022 14.8 6.3 2.8 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Metallothio_2 PF01439.18 EGD97788.1 - 0.072 14.0 22.1 0.1 13.5 7.0 3.6 3 0 0 3 3 3 0 Metallothionein DUF543 PF04418.12 EGD97789.1 - 1.5e-27 95.4 0.0 1.7e-27 95.2 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF543) Urb2 PF10441.9 EGD97790.1 - 1.3e-63 214.7 4.8 2.5e-63 213.7 0.0 3.2 3 0 0 3 3 3 1 Urb2/Npa2 family A_deaminase PF00962.22 EGD97791.1 - 7.9e-25 87.9 0.0 9.2e-25 87.6 0.0 1.0 1 0 0 1 1 1 1 Adenosine/AMP deaminase p450 PF00067.22 EGD97792.1 - 7.8e-77 259.0 0.0 9.5e-77 258.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 TAXi_C PF14541.6 EGD97792.1 - 0.072 12.9 0.0 0.16 11.7 0.0 1.5 1 0 0 1 1 1 0 Xylanase inhibitor C-terminal WD40 PF00400.32 EGD97793.1 - 9.6e-33 111.7 9.5 2.8e-08 34.3 0.1 5.7 5 1 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EGD97793.1 - 0.00037 20.7 0.0 2.3 8.6 0.0 3.8 4 1 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EGD97793.1 - 0.0042 15.8 0.2 0.024 13.3 0.0 2.2 2 0 0 2 2 2 1 Nucleoporin Nup120/160 Pox_A_type_inc PF04508.12 EGD97793.1 - 0.061 13.2 0.1 0.13 12.1 0.1 1.6 1 0 0 1 1 1 0 Viral A-type inclusion protein repeat Rx_N PF18052.1 EGD97793.1 - 0.11 12.8 0.0 0.21 11.9 0.0 1.4 1 0 0 1 1 1 0 Rx N-terminal domain CHAP PF05257.16 EGD97793.1 - 0.12 13.0 0.0 4.1 8.1 0.0 2.5 2 0 0 2 2 2 0 CHAP domain zf-C2H2 PF00096.26 EGD97794.1 - 1.5e-06 28.3 8.5 0.00053 20.3 0.3 3.4 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_aberr PF17017.5 EGD97794.1 - 7.5e-05 22.9 0.4 0.00012 22.3 0.0 1.5 2 0 0 2 2 2 1 Aberrant zinc-finger Spc29 PF17082.5 EGD97794.1 - 0.00043 20.2 0.2 0.00074 19.4 0.2 1.3 1 0 0 1 1 1 1 Spindle Pole Component 29 APC_N_CC PF16689.5 EGD97794.1 - 0.0083 16.2 0.1 0.019 15.0 0.1 1.6 1 0 0 1 1 1 1 Coiled-coil N-terminus of APC, dimerisation domain ATG16 PF08614.11 EGD97794.1 - 0.029 14.6 0.0 0.054 13.7 0.0 1.4 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) zf-C2H2_4 PF13894.6 EGD97794.1 - 0.031 15.1 0.8 7.3 7.7 0.1 3.0 2 1 0 2 2 2 0 C2H2-type zinc finger Transpos_assoc PF13963.6 EGD97794.1 - 0.073 13.4 0.5 1.2 9.5 0.1 2.2 2 0 0 2 2 2 0 Transposase-associated domain Cep57_MT_bd PF06657.13 EGD97794.1 - 0.14 12.6 2.5 8 7.0 0.1 2.4 2 0 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 MPS2 PF17060.5 EGD97794.1 - 0.3 10.3 0.5 0.41 9.9 0.5 1.1 1 0 0 1 1 1 0 Monopolar spindle protein 2 Lebercilin PF15619.6 EGD97794.1 - 0.54 9.9 4.9 0.52 9.9 1.0 2.0 2 0 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease DSPc PF00782.20 EGD97795.1 - 5.2e-12 45.7 0.0 1.5e-11 44.3 0.0 1.7 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Init_tRNA_PT PF04179.12 EGD97795.1 - 7.5e-05 23.0 0.0 0.00014 22.2 0.0 1.4 1 0 0 1 1 1 1 Rit1 DUSP-like domain AI-2E_transport PF01594.16 EGD97795.1 - 0.2 10.8 0.0 7.2 5.7 0.0 2.1 2 0 0 2 2 2 0 AI-2E family transporter Ribosomal_L5e PF17144.4 EGD97796.1 - 0.12 12.4 0.1 0.29 11.1 0.0 1.6 2 0 0 2 2 2 0 Ribosomal large subunit proteins 60S L5, and 50S L18 SNF2_N PF00176.23 EGD97797.1 - 5.4e-63 212.8 0.1 5.4e-63 212.8 0.1 1.9 2 1 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EGD97797.1 - 8e-22 77.7 0.2 1.3e-20 73.8 0.0 3.0 3 0 0 3 3 3 1 Helicase conserved C-terminal domain HDA2-3 PF11496.8 EGD97797.1 - 1.5e-05 24.4 2.4 0.0062 15.7 0.0 4.0 3 1 0 3 3 3 2 Class II histone deacetylase complex subunits 2 and 3 Spt20 PF12090.8 EGD97797.1 - 2.6 7.6 13.1 7.5 6.1 13.1 1.8 1 0 0 1 1 1 0 Spt20 family Shugoshin_C PF07557.11 EGD97797.1 - 3.1 7.7 6.6 3.6 7.5 3.1 2.7 2 0 0 2 2 2 0 Shugoshin C terminus End3 PF12761.7 EGD97798.1 - 1.1e-72 244.3 1.5 1.5e-72 243.9 1.5 1.2 1 0 0 1 1 1 1 Actin cytoskeleton-regulatory complex protein END3 EF-hand_4 PF12763.7 EGD97798.1 - 2.4e-51 172.0 0.1 5e-49 164.6 0.0 2.4 2 0 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand EF-hand_1 PF00036.32 EGD97798.1 - 8.5e-08 31.2 0.2 2.6e-07 29.7 0.2 1.9 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 EGD97798.1 - 1.2e-06 28.9 0.7 6.1e-06 26.6 0.1 2.5 3 1 0 3 3 3 1 EF-hand domain pair EF-hand_6 PF13405.6 EGD97798.1 - 9.6e-05 22.0 0.5 0.00043 20.0 0.2 2.3 2 0 0 2 2 2 1 EF-hand domain EF-hand_8 PF13833.6 EGD97798.1 - 0.0016 18.2 0.2 0.0053 16.6 0.1 1.9 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.6 EGD97798.1 - 0.0029 17.0 1.0 0.0094 15.4 0.2 2.2 2 0 0 2 2 2 1 EF hand NPV_P10 PF05531.12 EGD97798.1 - 0.016 15.7 0.2 0.23 11.9 0.1 2.5 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein SKA1 PF07160.12 EGD97798.1 - 0.027 14.3 0.3 0.053 13.4 0.3 1.5 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 1 DUF4407 PF14362.6 EGD97798.1 - 0.075 12.4 5.2 0.11 11.9 5.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) COG2 PF06148.11 EGD97798.1 - 0.88 9.7 4.6 2.3 8.3 0.6 2.7 3 0 0 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 Spc7 PF08317.11 EGD97798.1 - 1.6 7.6 11.5 0.26 10.1 4.3 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein Wtap PF17098.5 EGD97798.1 - 2.3 8.1 9.6 2 8.3 7.8 1.7 2 0 0 2 2 2 0 WTAP/Mum2p family Sec2p PF06428.11 EGD97798.1 - 2.4 8.2 10.2 7.6 6.6 0.9 2.5 1 1 1 2 2 2 0 GDP/GTP exchange factor Sec2p Med9 PF07544.13 EGD97798.1 - 3.4 7.8 5.8 0.48 10.6 0.2 2.4 3 0 0 3 3 2 0 RNA polymerase II transcription mediator complex subunit 9 Mit_KHE1 PF10173.9 EGD97799.1 - 3.8e-66 222.8 0.7 3.8e-66 222.8 0.7 1.4 2 0 0 2 2 2 1 Mitochondrial K+-H+ exchange-related SCAB_CC PF16712.5 EGD97799.1 - 0.0016 18.3 0.5 0.14 12.0 0.1 2.2 2 0 0 2 2 2 2 Coiled-coil regions of plant-specific actin-binding protein ABC2_membrane_4 PF12730.7 EGD97799.1 - 0.12 12.3 0.0 0.18 11.7 0.0 1.3 1 0 0 1 1 1 0 ABC-2 family transporter protein MARVEL PF01284.23 EGD97800.1 - 0.0036 17.3 2.7 0.0078 16.3 2.7 1.5 1 0 0 1 1 1 1 Membrane-associating domain KcnmB2_inactiv PF09303.10 EGD97800.1 - 0.0086 15.8 0.5 0.035 13.9 0.5 2.1 1 0 0 1 1 1 1 KCNMB2, ball and chain domain DUF1418 PF07214.12 EGD97800.1 - 0.12 12.2 0.0 0.12 12.2 0.0 2.1 3 0 0 3 3 3 0 Protein of unknown function (DUF1418) Cupin_1 PF00190.22 EGD97801.1 - 1e-10 41.4 0.1 1.4e-10 41.0 0.1 1.2 1 0 0 1 1 1 1 Cupin Cupin_2 PF07883.11 EGD97801.1 - 4.7e-08 32.6 0.1 7.1e-08 32.1 0.1 1.3 1 0 0 1 1 1 1 Cupin domain ARD PF03079.14 EGD97801.1 - 0.00035 20.8 0.0 0.00049 20.3 0.0 1.2 1 0 0 1 1 1 1 ARD/ARD' family Cupin_6 PF12852.7 EGD97801.1 - 0.00056 19.7 0.1 0.00068 19.4 0.1 1.1 1 0 0 1 1 1 1 Cupin AraC_binding PF02311.19 EGD97801.1 - 0.0022 17.9 0.1 0.0025 17.7 0.1 1.1 1 0 0 1 1 1 1 AraC-like ligand binding domain Cullin PF00888.22 EGD97802.1 - 2.3e-186 621.1 5.0 3e-186 620.7 5.0 1.2 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 EGD97802.1 - 6.9e-27 93.3 2.3 6.9e-27 93.3 2.3 2.3 2 0 0 2 2 2 1 Cullin protein neddylation domain Avl9 PF09794.9 EGD97803.1 - 9.5e-144 478.8 0.0 1.3e-143 478.3 0.0 1.2 1 0 0 1 1 1 1 Transport protein Avl9 SPA PF08616.10 EGD97803.1 - 4.9e-08 32.9 0.1 0.00044 20.2 0.0 2.5 2 0 0 2 2 2 2 Stabilization of polarity axis DUF2347 PF09804.9 EGD97803.1 - 2.5e-07 30.6 8.5 7.6e-06 25.7 0.7 3.6 2 1 0 2 2 2 1 Uncharacterized conserved protein (DUF2347) IcmF-related PF06761.12 EGD97803.1 - 0.02 14.4 1.2 1.4 8.3 0.0 2.2 2 0 0 2 2 2 0 Intracellular multiplication and human macrophage-killing Afi1 PF07792.12 EGD97803.1 - 0.11 13.0 1.7 3.9 8.0 0.0 2.4 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Pkinase PF00069.25 EGD97804.1 - 2.1e-67 227.2 0.0 2.7e-67 226.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD97804.1 - 1.5e-32 112.9 0.0 2e-32 112.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EGD97804.1 - 1.1e-05 24.6 0.1 1.4e-05 24.2 0.1 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 EGD97804.1 - 7e-05 22.3 0.1 0.00023 20.6 0.1 1.7 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EGD97804.1 - 0.00032 20.1 0.0 0.024 14.0 0.0 2.1 1 1 1 2 2 2 1 Kinase-like APH PF01636.23 EGD97804.1 - 0.00054 20.0 0.1 0.0018 18.2 0.0 1.9 1 1 1 2 2 2 1 Phosphotransferase enzyme family FTA2 PF13095.6 EGD97804.1 - 0.012 15.3 0.0 0.023 14.3 0.0 1.5 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 RIO1 PF01163.22 EGD97804.1 - 0.036 13.7 0.0 0.052 13.1 0.0 1.3 1 0 0 1 1 1 0 RIO1 family Connexin PF00029.19 EGD97806.1 - 0.019 14.7 2.8 0.022 14.5 2.8 1.1 1 0 0 1 1 1 0 Connexin Presenilin PF01080.17 EGD97806.1 - 0.03 13.1 1.9 0.031 13.0 1.9 1.1 1 0 0 1 1 1 0 Presenilin RPN2_C PF18004.1 EGD97806.1 - 0.067 13.1 7.3 0.087 12.7 7.3 1.1 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain FAM176 PF14851.6 EGD97806.1 - 0.076 12.7 7.1 0.1 12.2 7.1 1.2 1 0 0 1 1 1 0 FAM176 family RPA43_OB PF17875.1 EGD97806.1 - 0.13 12.9 1.8 0.21 12.2 1.8 1.3 1 0 0 1 1 1 0 RPA43 OB domain in RNA Pol I DUF2151 PF10221.9 EGD97806.1 - 0.17 10.4 1.3 0.19 10.3 1.3 1.0 1 0 0 1 1 1 0 Cell cycle and development regulator CCDC71L PF15374.6 EGD97806.1 - 0.24 10.6 5.0 0.25 10.5 5.0 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 71L API5 PF05918.11 EGD97806.1 - 0.29 9.9 2.4 0.34 9.7 2.4 1.1 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) Serinc PF03348.15 EGD97806.1 - 0.36 9.7 0.4 0.4 9.6 0.4 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) SART-1 PF03343.13 EGD97806.1 - 0.47 8.9 18.7 0.57 8.7 18.7 1.0 1 0 0 1 1 1 0 SART-1 family Eapp_C PF10238.9 EGD97806.1 - 0.55 10.3 6.1 0.74 9.9 6.1 1.2 1 0 0 1 1 1 0 E2F-associated phosphoprotein Rrn6 PF10214.9 EGD97806.1 - 0.57 8.6 10.6 0.63 8.5 10.6 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor DUF2828 PF11443.8 EGD97806.1 - 0.7 7.9 7.8 0.82 7.7 7.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Peptidase_S49_N PF08496.10 EGD97806.1 - 0.78 9.8 3.5 1.2 9.1 3.5 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal RR_TM4-6 PF06459.12 EGD97806.1 - 1 9.1 7.4 1.3 8.8 7.4 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Afi1 PF07792.12 EGD97806.1 - 1.3 9.5 4.9 1.7 9.1 4.9 1.1 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking NPR3 PF03666.13 EGD97806.1 - 1.8 7.3 11.1 2.3 6.9 11.1 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 AAA_11 PF13086.6 EGD97806.1 - 3.8 7.2 6.8 4.7 6.9 6.8 1.1 1 0 0 1 1 1 0 AAA domain CDC45 PF02724.14 EGD97806.1 - 4.8 5.4 15.3 5.8 5.1 15.3 1.1 1 0 0 1 1 1 0 CDC45-like protein MCM_bind PF09739.9 EGD97806.1 - 6.4 5.1 6.8 8 4.8 6.8 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor IL28A PF15177.6 EGD97807.1 - 0.084 12.7 0.6 0.17 11.7 0.6 1.4 1 0 0 1 1 1 0 Interleukin-28A MCU PF04678.13 EGD97807.1 - 0.13 12.3 0.1 0.22 11.6 0.1 1.3 1 0 0 1 1 1 0 Mitochondrial calcium uniporter zf-C2H2 PF00096.26 EGD97807.1 - 0.72 10.4 7.2 3.4 8.3 0.3 3.1 2 0 0 2 2 2 0 Zinc finger, C2H2 type KTI12 PF08433.10 EGD97808.1 - 1.5e-66 224.6 0.0 6.1e-66 222.7 0.0 1.8 1 1 0 1 1 1 1 Chromatin associated protein KTI12 DUF243 PF03103.17 EGD97808.1 - 0.011 16.0 1.8 0.069 13.5 0.4 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF243) DUF3328 PF11807.8 EGD97809.1 - 5.9e-46 157.0 0.1 8.6e-46 156.5 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) R2K_2 PF18299.1 EGD97809.1 - 0.11 12.3 0.0 0.22 11.4 0.0 1.4 1 0 0 1 1 1 0 ATP-grasp domain, R2K clade family 2 Palm_thioest PF02089.15 EGD97812.1 - 4.4e-83 278.8 0.0 5.1e-83 278.6 0.0 1.0 1 0 0 1 1 1 1 Palmitoyl protein thioesterase Abhydrolase_1 PF00561.20 EGD97812.1 - 0.0026 17.4 0.1 0.0047 16.6 0.1 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold DUF915 PF06028.11 EGD97812.1 - 0.0085 15.5 0.0 0.016 14.5 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF915) Abhydrolase_6 PF12697.7 EGD97812.1 - 0.022 15.4 0.0 0.027 15.1 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family Acetyltransf_1 PF00583.25 EGD97813.1 - 1.2e-07 32.0 0.0 1.6e-07 31.6 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EGD97813.1 - 5.3e-07 30.0 0.0 8.4e-07 29.3 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EGD97813.1 - 9.1e-06 25.6 0.0 1.5e-05 24.9 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EGD97813.1 - 0.008 16.1 0.0 0.03 14.3 0.0 2.0 2 1 0 2 2 2 1 FR47-like protein Acetyltransf_CG PF14542.6 EGD97813.1 - 0.051 13.7 0.0 0.11 12.7 0.0 1.5 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase DUF3638 PF12340.8 EGD97814.1 - 4.8e-91 304.1 0.1 8.5e-91 303.3 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3638) DUF3645 PF12359.8 EGD97814.1 - 1.1e-15 56.7 0.7 3.8e-14 51.8 0.1 2.7 2 0 0 2 2 2 1 Protein of unknown function (DUF3645) CENP-L PF13092.6 EGD97815.1 - 2.3e-52 177.5 0.1 3e-52 177.1 0.1 1.2 1 0 0 1 1 1 1 Kinetochore complex Sim4 subunit Fta1 Cue1_U7BR PF18499.1 EGD97815.1 - 0.12 12.5 0.1 0.25 11.4 0.1 1.5 1 0 0 1 1 1 0 Ubc7p-binding region of Cue1 Sulfate_transp PF00916.20 EGD97816.1 - 6.2e-59 199.7 7.4 9e-59 199.1 7.4 1.1 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 EGD97816.1 - 1.6e-15 56.7 0.0 2.8e-15 56.0 0.0 1.3 1 0 0 1 1 1 1 STAS domain STAS_2 PF13466.6 EGD97816.1 - 0.0044 17.3 0.0 0.011 16.1 0.0 1.7 1 0 0 1 1 1 1 STAS domain MFS_MOT1 PF16983.5 EGD97816.1 - 0.2 12.1 11.7 0.077 13.4 5.4 2.6 2 0 0 2 2 2 0 Molybdate transporter of MFS superfamily EIF_2_alpha PF07541.12 EGD97817.1 - 2.5e-36 124.3 0.0 4.8e-36 123.4 0.0 1.5 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 2 alpha subunit S1 PF00575.23 EGD97817.1 - 1.6e-13 50.8 0.9 3e-13 49.9 0.9 1.4 1 0 0 1 1 1 1 S1 RNA binding domain RHH_1 PF01402.21 EGD97817.1 - 1.1 9.3 3.9 21 5.3 0.0 2.9 2 0 0 2 2 2 0 Ribbon-helix-helix protein, copG family PKD_channel PF08016.12 EGD97818.1 - 6.9e-08 31.6 20.4 3.9e-07 29.1 16.6 2.8 2 1 0 2 2 2 1 Polycystin cation channel DNA_alkylation PF08713.11 EGD97818.1 - 0.15 11.8 0.2 0.31 10.7 0.2 1.4 1 0 0 1 1 1 0 DNA alkylation repair enzyme CAML PF14963.6 EGD97818.1 - 2.2 8.3 4.0 2 8.4 2.0 1.9 2 0 0 2 2 2 0 Calcium signal-modulating cyclophilin ligand FYVE PF01363.21 EGD97819.1 - 2.8e-22 78.6 24.4 4.3e-17 62.0 5.7 3.1 3 0 0 3 3 3 2 FYVE zinc finger Rbsn PF11464.8 EGD97819.1 - 1.3e-17 63.3 0.6 3.3e-17 61.9 0.6 1.8 1 0 0 1 1 1 1 Rabenosyn Rab binding domain zf-Di19 PF05605.12 EGD97819.1 - 0.0013 19.0 13.6 0.011 16.0 0.0 3.2 4 0 0 4 4 3 2 Drought induced 19 protein (Di19), zinc-binding OrsD PF12013.8 EGD97819.1 - 0.005 17.3 0.4 0.097 13.1 0.0 3.1 3 0 0 3 3 3 1 Orsellinic acid/F9775 biosynthesis cluster protein D zf-AN1 PF01428.16 EGD97819.1 - 0.0077 16.4 3.3 0.0077 16.4 3.3 4.2 4 1 1 5 5 5 1 AN1-like Zinc finger YqaH PF17448.2 EGD97819.1 - 0.014 15.7 0.2 0.037 14.3 0.2 1.7 1 0 0 1 1 1 0 Uncharacterized YqaH-like Fer4_21 PF14697.6 EGD97819.1 - 0.02 15.0 4.2 0.02 15.0 4.2 2.6 3 0 0 3 3 2 0 4Fe-4S dicluster domain TMF_TATA_bd PF12325.8 EGD97819.1 - 0.063 13.5 0.5 0.063 13.5 0.5 2.5 3 0 0 3 3 3 0 TATA element modulatory factor 1 TATA binding RE_BstXI PF09552.10 EGD97819.1 - 0.084 12.1 0.1 0.18 11.0 0.1 1.5 1 0 0 1 1 1 0 BstXI restriction endonuclease Prok-RING_4 PF14447.6 EGD97819.1 - 0.29 11.0 0.1 0.29 11.0 0.1 4.8 5 1 1 6 6 6 0 Prokaryotic RING finger family 4 zf-C2H2_4 PF13894.6 EGD97819.1 - 0.79 10.7 0.0 0.79 10.7 0.0 6.3 6 1 0 6 6 6 0 C2H2-type zinc finger UBZ_FAAP20 PF15750.5 EGD97819.1 - 2.3 8.2 4.3 3.3 7.7 0.4 3.1 3 0 0 3 3 3 0 Ubiquitin-binding zinc-finger E1-E2_ATPase PF00122.20 EGD97820.1 - 3.4e-20 72.3 0.0 8.6e-20 71.0 0.0 1.7 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.26 EGD97820.1 - 1.1e-10 42.2 4.6 5.8e-10 39.8 4.6 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 EGD97820.1 - 0.0034 17.2 0.2 0.026 14.3 0.1 2.2 1 1 1 2 2 2 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EGD97820.1 - 0.014 15.4 0.0 0.042 13.9 0.0 1.7 1 0 0 1 1 1 0 Cation transport ATPase (P-type) S6PP PF05116.13 EGD97820.1 - 0.057 12.9 0.1 0.26 10.8 0.0 2.0 2 0 0 2 2 2 0 Sucrose-6F-phosphate phosphohydrolase ATP1G1_PLM_MAT8 PF02038.16 EGD97821.1 - 0.97 8.9 3.1 1.6 8.2 0.1 2.5 2 0 0 2 2 2 0 ATP1G1/PLM/MAT8 family Bac_export_2 PF01312.19 EGD97821.1 - 5.8 6.0 8.6 1.6 7.9 5.2 1.6 1 1 1 2 2 2 0 FlhB HrpN YscU SpaS Family AA_permease_2 PF13520.6 EGD97822.1 - 1.5e-62 211.8 51.5 1.9e-62 211.5 51.5 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EGD97822.1 - 3.6e-20 72.0 40.5 3.6e-20 72.0 40.5 1.3 1 1 0 1 1 1 1 Amino acid permease GLTP PF08718.11 EGD97823.1 - 4.2e-47 160.2 0.1 5.6e-47 159.8 0.1 1.2 1 0 0 1 1 1 1 Glycolipid transfer protein (GLTP) DUF3915 PF13054.6 EGD97824.1 - 3.1 7.8 7.6 3.3 7.7 7.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Peptidase_S49_N PF08496.10 EGD97824.1 - 3.9 7.5 10.3 3.9 7.5 10.3 1.1 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Atrophin-1 PF03154.15 EGD97824.1 - 8.6 4.5 11.4 7.8 4.6 11.4 1.0 1 0 0 1 1 1 0 Atrophin-1 family PH_4 PF15404.6 EGD97825.1 - 1.2e-26 93.7 2.9 1.1e-25 90.5 1.4 3.2 2 1 0 2 2 2 1 Pleckstrin homology domain Spo7_2_N PF15407.6 EGD97825.1 - 4.4e-22 77.5 0.1 1.1e-21 76.2 0.1 1.7 1 0 0 1 1 1 1 Sporulation protein family 7 PH PF00169.29 EGD97825.1 - 2.4e-06 28.0 0.4 1.5 9.4 0.0 4.2 4 0 0 4 4 4 2 PH domain PH_6 PF15406.6 EGD97825.1 - 0.0015 18.8 0.1 0.12 12.7 0.1 2.8 2 0 0 2 2 2 1 Pleckstrin homology domain PH_13 PF16652.5 EGD97825.1 - 0.026 14.4 0.4 4.1 7.2 0.0 2.5 2 0 0 2 2 2 0 Pleckstrin homology domain PH_9 PF15410.6 EGD97825.1 - 0.036 14.4 0.0 0.58 10.5 0.0 2.8 3 0 0 3 3 3 0 Pleckstrin homology domain Spt5_N PF11942.8 EGD97825.1 - 9.3 7.3 12.8 0.68 10.9 5.9 2.7 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal NmrA PF05368.13 EGD97826.1 - 0.0016 18.1 0.0 0.0051 16.4 0.0 1.7 1 1 0 1 1 1 1 NmrA-like family TrkA_N PF02254.18 EGD97826.1 - 0.03 14.6 0.0 0.083 13.2 0.0 1.8 2 1 0 2 2 2 0 TrkA-N domain F420_oxidored PF03807.17 EGD97826.1 - 0.13 12.9 0.0 0.26 11.9 0.0 1.7 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Shikimate_DH PF01488.20 EGD97826.1 - 0.2 11.7 0.0 0.35 10.9 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase TFIIS_C PF01096.18 EGD97827.1 - 9.8e-19 66.9 2.3 9.8e-19 66.9 2.3 3.0 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) RNA_POL_M_15KD PF02150.16 EGD97827.1 - 8.6e-06 25.5 9.9 0.0002 21.1 5.3 3.4 3 1 0 3 3 3 1 RNA polymerases M/15 Kd subunit Zn_Tnp_IS1595 PF12760.7 EGD97827.1 - 0.0065 16.4 6.7 0.12 12.3 1.3 2.5 2 0 0 2 2 2 2 Transposase zinc-ribbon domain C1_4 PF07975.12 EGD97827.1 - 0.098 12.9 4.9 1.4 9.2 0.3 2.6 2 2 0 2 2 2 0 TFIIH C1-like domain zf-Mss51 PF13824.6 EGD97827.1 - 0.12 12.5 0.1 0.12 12.5 0.1 2.0 2 1 0 2 2 2 0 Zinc-finger of mitochondrial splicing suppressor 51 zf-H2C2_2 PF13465.6 EGD97827.1 - 2.7 8.6 12.4 3.9 8.1 0.3 3.6 4 0 0 4 4 4 0 Zinc-finger double domain zinc_ribbon_4 PF13717.6 EGD97827.1 - 3.1 7.8 10.8 15 5.6 0.2 3.6 4 0 0 4 4 4 0 zinc-ribbon domain Rubredoxin PF00301.20 EGD97827.1 - 4.3 7.4 8.1 8.6 6.5 0.2 3.4 3 0 0 3 3 3 0 Rubredoxin GTP_EFTU_D3 PF03143.17 EGD97828.1 - 3.7e-42 143.2 0.0 8.7e-42 142.0 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU PF00009.27 EGD97828.1 - 1.9e-40 138.5 0.0 3.3e-40 137.7 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 EGD97828.1 - 1.1e-14 54.5 1.4 2.7e-14 53.3 1.4 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 GTP_EFTU_D4 PF14578.6 EGD97828.1 - 0.0096 15.8 1.2 0.024 14.5 1.2 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 4 MMR_HSR1 PF01926.23 EGD97828.1 - 0.064 13.3 0.1 0.13 12.4 0.1 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase Chalcone_2 PF16035.5 EGD97829.1 - 3.6e-73 245.7 0.0 5.7e-73 245.1 0.0 1.3 1 0 0 1 1 1 1 Chalcone isomerase like Chalcone_3 PF16036.5 EGD97829.1 - 0.016 15.3 0.1 0.055 13.6 0.0 1.9 2 0 0 2 2 2 0 Chalcone isomerase-like Glutaredoxin PF00462.24 EGD97830.1 - 5.3e-20 71.4 0.0 7.8e-20 70.9 0.0 1.3 1 0 0 1 1 1 1 Glutaredoxin GST_N_3 PF13417.6 EGD97830.1 - 0.029 14.8 0.0 0.043 14.2 0.0 1.4 1 1 0 1 1 1 0 Glutathione S-transferase, N-terminal domain DUF836 PF05768.14 EGD97830.1 - 0.037 14.4 0.1 0.052 14.0 0.1 1.4 1 1 0 1 1 1 0 Glutaredoxin-like domain (DUF836) Adeno_E3_CR2 PF02439.15 EGD97833.1 - 2.2 8.1 4.4 4.6 7.1 4.4 1.4 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 TFIIA PF03153.13 EGD97833.1 - 4.6 7.1 9.0 6.2 6.7 9.0 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit EB1 PF03271.17 EGD97834.1 - 2e-17 63.1 1.3 3.7e-17 62.3 1.3 1.5 1 0 0 1 1 1 1 EB1-like C-terminal motif CH PF00307.31 EGD97834.1 - 2.1e-06 27.8 0.4 5.8e-06 26.5 0.5 1.7 1 1 1 2 2 2 1 Calponin homology (CH) domain Herpes_UL6 PF01763.16 EGD97834.1 - 0.00055 18.6 0.0 0.00078 18.1 0.0 1.2 1 0 0 1 1 1 1 Herpesvirus UL6 like CH_2 PF06294.11 EGD97834.1 - 0.12 12.5 0.1 0.17 12.0 0.1 1.3 1 0 0 1 1 1 0 CH-like domain in sperm protein ADH_zinc_N_2 PF13602.6 EGD97835.1 - 5.2e-13 50.2 0.0 8.2e-13 49.6 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 EGD97835.1 - 6.9e-09 35.8 0.0 1.2e-08 35.0 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase WD40 PF00400.32 EGD97836.1 - 3.6e-26 90.9 12.1 6.2e-06 26.9 0.1 7.0 6 0 0 6 6 6 5 WD domain, G-beta repeat F-box-like PF12937.7 EGD97836.1 - 4.1e-09 36.2 0.1 8e-09 35.3 0.1 1.5 1 0 0 1 1 1 1 F-box-like PQQ PF01011.21 EGD97836.1 - 2e-05 24.3 0.0 1.4 9.0 0.0 3.8 3 0 0 3 3 3 2 PQQ enzyme repeat F-box PF00646.33 EGD97836.1 - 3.3e-05 23.6 0.1 6.8e-05 22.6 0.1 1.5 1 0 0 1 1 1 1 F-box domain PQQ_2 PF13360.6 EGD97836.1 - 0.00011 21.9 0.1 0.33 10.5 0.0 2.4 1 1 1 2 2 2 2 PQQ-like domain ANAPC4_WD40 PF12894.7 EGD97836.1 - 0.0053 17.0 0.8 8 6.8 0.0 4.5 2 1 4 6 6 6 1 Anaphase-promoting complex subunit 4 WD40 domain STE PF02200.16 EGD97836.1 - 0.04 14.3 0.1 0.73 10.3 0.0 2.4 2 0 0 2 2 2 0 STE like transcription factor DUF5046 PF16465.5 EGD97836.1 - 0.04 13.4 0.1 0.56 9.6 0.0 2.6 2 1 1 3 3 3 0 Domain of unknown function (DUF5046) F-box_4 PF15966.5 EGD97836.1 - 0.081 12.8 0.0 0.19 11.6 0.0 1.5 1 0 0 1 1 1 0 F-box PALB2_WD40 PF16756.5 EGD97836.1 - 0.091 11.7 0.1 3.8 6.4 0.0 2.3 1 1 1 2 2 2 0 Partner and localizer of BRCA2 WD40 domain SelP_N PF04592.14 EGD97836.1 - 2.8 7.3 13.3 4.4 6.6 13.3 1.4 1 0 0 1 1 1 0 Selenoprotein P, N terminal region ADH_N PF08240.12 EGD97837.1 - 8.2e-26 90.0 4.4 1.4e-25 89.3 4.4 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EGD97837.1 - 1.2e-15 57.6 0.0 9e-15 54.8 0.0 2.2 2 0 0 2 2 2 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 EGD97837.1 - 0.00022 20.6 0.2 0.00042 19.7 0.2 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain DHDPS PF00701.22 EGD97838.1 - 6.7e-34 116.9 0.0 2.7e-32 111.7 0.0 2.0 1 1 0 1 1 1 1 Dihydrodipicolinate synthetase family GFO_IDH_MocA PF01408.22 EGD97839.1 - 3.5e-08 34.3 0.2 1.4e-07 32.4 0.2 2.0 1 1 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold Cation_ATPase_C PF00689.21 EGD97840.1 - 1.9e-47 161.4 7.8 1.9e-47 161.4 7.8 2.1 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 EGD97840.1 - 1.4e-35 122.4 0.0 1.4e-35 122.4 0.0 2.6 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase PF13246.6 EGD97840.1 - 6e-21 74.3 0.0 1.1e-20 73.5 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 EGD97840.1 - 2.4e-16 60.7 1.8 1e-15 58.6 1.8 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EGD97840.1 - 2.8e-08 33.3 0.2 2.1e-07 30.5 0.0 2.4 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 EGD97840.1 - 3.1e-05 23.9 0.0 0.0014 18.5 0.1 2.4 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase DUF1774 PF08611.10 EGD97840.1 - 0.055 13.8 4.7 0.26 11.6 0.2 2.9 2 0 0 2 2 2 0 Fungal protein of unknown function (DUF1774) Ferlin_C PF16165.5 EGD97840.1 - 0.22 11.5 1.8 0.37 10.7 0.1 2.3 2 0 0 2 2 2 0 Ferlin C-terminus P16-Arc PF04699.14 EGD97841.1 - 1.5e-46 158.6 0.0 1.7e-46 158.4 0.0 1.0 1 0 0 1 1 1 1 ARP2/3 complex 16 kDa subunit (p16-Arc) Methyltransf_11 PF08241.12 EGD97842.1 - 9.3e-09 35.8 0.0 2e-08 34.8 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EGD97842.1 - 1.4e-07 31.5 0.0 2.9e-07 30.5 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EGD97842.1 - 2.2e-06 28.3 0.0 6.5e-06 26.8 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EGD97842.1 - 0.00012 22.8 0.0 0.00024 21.8 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EGD97842.1 - 0.001 18.9 0.0 0.004 17.0 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EGD97842.1 - 0.0075 15.6 0.0 0.012 14.9 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family GhoS PF11080.8 EGD97842.1 - 0.17 11.9 0.0 2 8.4 0.0 2.3 2 0 0 2 2 2 0 Endoribonuclease GhoS Dynactin_p62 PF05502.13 EGD97843.1 - 2e-207 689.7 0.1 2.4e-207 689.5 0.1 1.0 1 0 0 1 1 1 1 Dynactin p62 family Ribosomal_S7e PF01251.18 EGD97844.1 - 1.2e-78 263.1 0.2 1.4e-78 262.9 0.2 1.0 1 0 0 1 1 1 1 Ribosomal protein S7e Vezatin PF12632.7 EGD97844.1 - 0.016 14.6 0.8 2.1 7.6 0.0 2.0 2 0 0 2 2 2 0 Mysoin-binding motif of peroxisomes EntA_Immun PF08951.10 EGD97844.1 - 0.04 14.3 0.1 0.09 13.1 0.1 1.6 1 0 0 1 1 1 0 Enterocin A Immunity XFP_N PF09364.10 EGD97845.1 - 2.3e-149 497.2 0.0 3.4e-149 496.6 0.0 1.2 1 0 0 1 1 1 1 XFP N-terminal domain XFP_C PF09363.10 EGD97845.1 - 6.9e-79 264.0 0.0 1e-78 263.5 0.0 1.2 1 0 0 1 1 1 1 XFP C-terminal domain XFP PF03894.15 EGD97845.1 - 2e-74 249.1 0.0 2.9e-74 248.6 0.0 1.2 1 0 0 1 1 1 1 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase vATP-synt_AC39 PF01992.16 EGD97845.1 - 0.16 11.4 0.0 0.3 10.6 0.0 1.4 1 0 0 1 1 1 0 ATP synthase (C/AC39) subunit Acetate_kinase PF00871.17 EGD97846.1 - 5.1e-87 292.1 0.0 4.8e-86 288.9 0.0 1.9 1 1 0 1 1 1 1 Acetokinase family MCM6_C PF18263.1 EGD97846.1 - 0.051 13.8 0.1 0.096 12.9 0.1 1.4 1 0 0 1 1 1 0 MCM6 C-terminal winged-helix domain DUF1467 PF07330.12 EGD97848.1 - 0.035 14.0 0.0 0.16 11.9 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1467) Ras PF00071.22 EGD97849.1 - 2.3e-55 186.6 0.0 2.9e-55 186.3 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EGD97849.1 - 5.9e-34 116.9 0.0 8.3e-34 116.4 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EGD97849.1 - 6.1e-13 48.6 0.0 1e-12 47.9 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EGD97849.1 - 5.3e-05 22.8 0.0 9.2e-05 22.1 0.0 1.3 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EGD97849.1 - 0.00028 20.9 0.0 0.00042 20.4 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EGD97849.1 - 0.00029 20.3 0.0 0.00033 20.1 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_16 PF13191.6 EGD97849.1 - 0.0013 19.1 0.0 0.0021 18.5 0.0 1.3 1 1 0 1 1 1 1 AAA ATPase domain Pkinase PF00069.25 EGD97850.1 - 4.3e-39 134.5 0.0 7.9e-39 133.6 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD97850.1 - 4.1e-26 91.8 0.0 9.5e-26 90.6 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Kdo PF06293.14 EGD97850.1 - 0.013 14.9 0.0 0.022 14.1 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EGD97850.1 - 0.013 14.8 0.0 0.02 14.2 0.0 1.2 1 0 0 1 1 1 0 Kinase-like Macoilin PF09726.9 EGD97851.1 - 1.9 7.0 16.0 3.3 6.1 16.0 1.4 1 0 0 1 1 1 0 Macoilin family Sugar_tr PF00083.24 EGD97853.1 - 6.7e-81 272.5 29.6 7.7e-81 272.2 29.6 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EGD97853.1 - 9.1e-13 47.8 40.0 9.3e-09 34.7 14.9 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily Dynamin_N PF00350.23 EGD97854.1 - 3e-18 66.5 0.0 4.3e-17 62.7 0.0 2.9 3 1 0 3 3 3 1 Dynamin family MMR_HSR1 PF01926.23 EGD97854.1 - 3e-07 30.5 0.3 5.7e-06 26.4 0.0 2.8 2 1 0 2 2 2 1 50S ribosome-binding GTPase ABC_tran PF00005.27 EGD97854.1 - 0.0003 21.3 0.9 0.0011 19.5 0.0 2.4 2 1 0 2 2 2 1 ABC transporter RsgA_GTPase PF03193.16 EGD97854.1 - 0.0073 16.2 0.1 0.0073 16.2 0.1 2.5 3 0 0 3 3 3 1 RsgA GTPase ATP-grasp_2 PF08442.10 EGD97854.1 - 0.039 13.5 0.2 0.039 13.5 0.2 1.8 2 0 0 2 2 2 0 ATP-grasp domain AAA_16 PF13191.6 EGD97854.1 - 0.069 13.5 0.0 1 9.8 0.0 2.8 2 0 0 2 2 2 0 AAA ATPase domain FtsK_SpoIIIE PF01580.18 EGD97854.1 - 0.094 12.1 0.3 0.45 9.8 0.1 2.0 2 0 0 2 2 2 0 FtsK/SpoIIIE family T2SSE PF00437.20 EGD97854.1 - 0.094 11.8 0.1 0.18 10.8 0.1 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein Adeno_IVa2 PF02456.15 EGD97854.1 - 0.11 11.3 0.1 0.27 10.0 0.0 1.6 2 0 0 2 2 2 0 Adenovirus IVa2 protein AIG1 PF04548.16 EGD97854.1 - 0.12 11.7 0.1 0.12 11.7 0.1 2.7 4 0 0 4 4 4 0 AIG1 family Mei5_like PF17021.5 EGD97854.1 - 5.3 7.1 7.1 2.3 8.3 1.0 3.0 3 0 0 3 3 3 0 Putative double-strand recombination repair-like DUF4451 PF14616.6 EGD97855.1 - 2.8e-21 76.0 0.1 4.8e-21 75.2 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4451) TPR_1 PF00515.28 EGD97856.1 - 1.1e-35 120.0 9.6 8.9e-07 28.5 0.0 7.6 8 0 0 8 8 7 6 Tetratricopeptide repeat TPR_2 PF07719.17 EGD97856.1 - 2.9e-34 114.4 11.7 1.3e-06 28.0 0.0 7.6 7 0 0 7 7 7 6 Tetratricopeptide repeat DnaJ PF00226.31 EGD97856.1 - 1.4e-26 92.4 4.4 1.6e-26 92.2 1.2 2.8 3 0 0 3 3 3 1 DnaJ domain TPR_19 PF14559.6 EGD97856.1 - 3e-24 85.3 10.5 9.6e-06 26.0 0.2 6.2 3 3 2 5 5 5 5 Tetratricopeptide repeat TPR_14 PF13428.6 EGD97856.1 - 1.7e-21 75.0 7.9 0.00032 21.3 0.0 8.8 3 3 6 9 9 8 6 Tetratricopeptide repeat TPR_11 PF13414.6 EGD97856.1 - 1.1e-20 73.0 11.8 1.8e-05 24.3 0.0 7.4 4 2 3 7 7 7 4 TPR repeat TPR_17 PF13431.6 EGD97856.1 - 2e-18 65.3 10.1 0.0014 18.9 0.2 6.8 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_8 PF13181.6 EGD97856.1 - 2.2e-18 64.9 6.6 0.006 16.7 0.0 7.0 7 0 0 7 7 6 4 Tetratricopeptide repeat TPR_12 PF13424.6 EGD97856.1 - 2.1e-14 53.5 9.0 0.023 15.0 0.0 5.7 4 1 0 5 5 5 3 Tetratricopeptide repeat TPR_7 PF13176.6 EGD97856.1 - 2.7e-14 52.0 8.2 0.05 13.7 0.0 7.0 7 0 0 7 7 6 4 Tetratricopeptide repeat TPR_9 PF13371.6 EGD97856.1 - 4.9e-13 49.0 2.0 0.0011 19.0 0.0 4.1 4 0 0 4 4 4 3 Tetratricopeptide repeat ANAPC3 PF12895.7 EGD97856.1 - 5.7e-13 48.9 2.6 0.00059 20.0 0.1 4.2 2 2 1 3 3 3 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_16 PF13432.6 EGD97856.1 - 8.8e-12 45.5 27.1 0.0017 18.9 0.0 6.5 6 1 2 8 8 6 4 Tetratricopeptide repeat TPR_6 PF13174.6 EGD97856.1 - 1.7e-09 37.7 11.2 0.0021 18.6 0.0 7.7 8 0 0 8 8 7 1 Tetratricopeptide repeat TPR_15 PF13429.6 EGD97856.1 - 1.6e-08 34.1 4.2 0.013 14.7 0.0 4.5 3 2 1 4 4 4 2 Tetratricopeptide repeat BTAD PF03704.17 EGD97856.1 - 1.5e-06 28.7 4.4 0.0011 19.4 0.4 4.3 3 2 0 3 3 3 1 Bacterial transcriptional activator domain Fis1_TPR_C PF14853.6 EGD97856.1 - 1.9e-06 27.8 4.6 0.099 12.7 0.0 4.9 2 1 3 5 5 4 1 Fis1 C-terminal tetratricopeptide repeat TPR_10 PF13374.6 EGD97856.1 - 9.2e-06 25.4 11.5 0.15 11.9 0.0 6.1 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_20 PF14561.6 EGD97856.1 - 0.00013 22.2 5.4 6.8 7.1 0.2 4.7 3 1 1 4 4 4 0 Tetratricopeptide repeat ChAPs PF09295.10 EGD97856.1 - 0.00016 20.8 0.1 0.076 12.0 0.0 2.5 2 1 0 2 2 2 2 ChAPs (Chs5p-Arf1p-binding proteins) Coatomer_E PF04733.14 EGD97856.1 - 0.0013 18.2 0.4 7.6 5.9 0.1 3.2 3 0 0 3 3 3 0 Coatomer epsilon subunit SRP_TPR_like PF17004.5 EGD97856.1 - 0.01 15.9 0.2 2 8.4 0.0 2.8 2 0 0 2 2 2 0 Putative TPR-like repeat TPR_MalT PF17874.1 EGD97856.1 - 0.03 13.7 0.6 0.3 10.4 0.1 2.3 2 1 0 2 2 2 0 MalT-like TPR region TPR_21 PF09976.9 EGD97856.1 - 0.068 12.9 4.9 16 5.1 0.0 4.6 2 2 2 5 5 5 0 Tetratricopeptide repeat-like domain MAS20 PF02064.15 EGD97856.1 - 0.074 13.2 0.0 2.4 8.3 0.0 3.2 3 0 0 3 3 3 0 MAS20 protein import receptor TPR_4 PF07721.14 EGD97856.1 - 0.43 11.4 0.0 0.43 11.4 0.0 5.7 6 0 0 6 6 4 0 Tetratricopeptide repeat Wzy_C_2 PF11846.8 EGD97856.1 - 0.45 10.4 5.8 3.6 7.5 0.2 3.3 3 1 1 4 4 4 0 Virulence factor membrane-bound polymerase, C-terminal MIT PF04212.18 EGD97856.1 - 1.3 9.2 0.0 1.3 9.2 0.0 4.3 6 0 0 6 6 5 0 MIT (microtubule interacting and transport) domain HHH_8 PF14716.6 EGD97856.1 - 2.7 8.4 7.0 1.9 8.9 0.1 3.9 5 0 0 5 5 4 0 Helix-hairpin-helix domain RPN7 PF10602.9 EGD97856.1 - 7 6.3 6.9 7.1 6.3 0.0 3.8 3 3 1 4 4 4 0 26S proteasome subunit RPN7 UPF0029 PF01205.19 EGD97859.1 - 0.16 12.3 0.1 0.29 11.5 0.1 1.4 1 0 0 1 1 1 0 Uncharacterized protein family UPF0029 DUF4508 PF14969.6 EGD97859.1 - 0.31 11.3 3.3 0.73 10.1 0.7 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4508) ATG16 PF08614.11 EGD97859.1 - 0.73 10.0 14.0 0.019 15.2 7.3 1.7 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) HEPN_RES_NTD1 PF18870.1 EGD97862.1 - 0.054 13.7 0.3 0.14 12.4 0.3 1.7 1 0 0 1 1 1 0 HEPN/RES N-terminal domain 1 APH PF01636.23 EGD97866.1 - 2.3e-09 37.5 0.1 1.1e-08 35.3 0.1 1.8 1 1 0 1 1 1 1 Phosphotransferase enzyme family DUF1679 PF07914.11 EGD97866.1 - 0.033 13.1 0.0 0.041 12.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1679) Choline_kinase PF01633.20 EGD97866.1 - 0.086 12.4 0.0 0.13 11.8 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase Protoglobin PF11563.8 EGD97868.1 - 9.9e-52 175.0 0.0 1.2e-51 174.8 0.0 1.0 1 0 0 1 1 1 1 Protoglobin CN_hydrolase PF00795.22 EGD97869.1 - 9.6e-37 126.7 0.0 1.5e-36 126.1 0.0 1.3 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase NAD_synthase PF02540.17 EGD97869.1 - 6.5e-25 87.7 0.0 1.3e-24 86.6 0.0 1.5 1 0 0 1 1 1 1 NAD synthase Pkinase PF00069.25 EGD97871.1 - 1.2e-62 211.7 0.0 1.5e-62 211.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD97871.1 - 1.6e-34 119.4 0.0 2.1e-34 119.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EGD97871.1 - 6.9e-07 28.9 0.0 1.1e-06 28.2 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EGD97871.1 - 0.00019 20.4 0.0 0.00028 19.8 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EGD97871.1 - 0.17 11.2 0.0 0.28 10.5 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Sec39 PF08314.11 EGD97872.1 - 2.4e-268 892.6 0.0 2.8e-268 892.4 0.0 1.0 1 0 0 1 1 1 1 Secretory pathway protein Sec39 Ndufs5 PF10200.9 EGD97873.1 - 0.00066 19.9 0.0 0.00074 19.7 0.0 1.1 1 0 0 1 1 1 1 NADH:ubiquinone oxidoreductase, NDUFS5-15kDa DnaJ PF00226.31 EGD97873.1 - 0.0062 16.7 0.4 0.0085 16.2 0.4 1.2 1 0 0 1 1 1 1 DnaJ domain COX6B PF02297.17 EGD97873.1 - 0.007 16.6 0.2 0.01 16.0 0.2 1.3 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb DUF3128 PF11326.8 EGD97873.1 - 0.053 13.9 1.7 0.35 11.3 1.7 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3128) UPF0203 PF05254.12 EGD97873.1 - 0.062 13.6 0.1 0.094 13.0 0.1 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0203) DUF3535 PF12054.8 EGD97874.1 - 1.8e-127 426.2 0.0 2.7e-126 422.4 0.0 2.6 3 0 0 3 3 3 1 Domain of unknown function (DUF3535) SNF2_N PF00176.23 EGD97874.1 - 8.6e-64 215.4 0.0 2.4e-63 214.0 0.0 1.6 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EGD97874.1 - 2e-19 70.0 0.0 5.9e-19 68.5 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HEAT PF02985.22 EGD97874.1 - 3.4e-18 64.2 7.5 0.0014 18.7 0.2 9.4 11 0 0 11 11 11 4 HEAT repeat HEAT_2 PF13646.6 EGD97874.1 - 3.8e-06 27.2 4.7 0.018 15.4 0.1 6.3 6 1 0 6 6 6 1 HEAT repeats Vac14_Fab1_bd PF12755.7 EGD97874.1 - 5.2e-06 27.0 0.1 0.56 10.8 0.0 4.1 3 1 0 4 4 4 2 Vacuolar 14 Fab1-binding region CLASP_N PF12348.8 EGD97874.1 - 0.00038 20.1 0.0 0.11 12.0 0.0 3.8 3 1 1 4 4 4 1 CLASP N terminal HEAT_EZ PF13513.6 EGD97874.1 - 0.0009 19.7 7.4 7.6 7.2 0.0 6.9 6 1 2 8 8 8 1 HEAT-like repeat TAF6_C PF07571.13 EGD97874.1 - 0.0023 18.2 0.1 0.35 11.2 0.0 4.4 5 0 0 5 5 5 1 TAF6 C-terminal HEAT repeat domain RTP1_C1 PF10363.9 EGD97874.1 - 0.043 14.0 0.0 0.8 9.9 0.0 3.3 2 1 0 2 2 2 0 Required for nuclear transport of RNA pol II C-terminus 1 Erythro_esteras PF05139.14 EGD97876.1 - 2.9e-124 415.3 1.8 3.4e-124 415.1 1.8 1.0 1 0 0 1 1 1 1 Erythromycin esterase Cofac_haem_bdg PF04187.13 EGD97876.1 - 0.00021 21.4 0.2 0.22 11.5 0.1 2.3 2 0 0 2 2 2 2 Haem-binding uptake, Tiki superfamily, ChaN Scs3p PF10261.9 EGD97878.1 - 1.4e-71 240.9 1.5 2.2e-71 240.3 1.5 1.2 1 0 0 1 1 1 1 Inositol phospholipid synthesis and fat-storage-inducing TM Zn_clus PF00172.18 EGD97879.1 - 0.0067 16.5 12.3 0.013 15.6 12.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain TYA PF01021.19 EGD97879.1 - 0.12 12.7 0.0 0.34 11.3 0.0 1.7 1 0 0 1 1 1 0 TYA transposon protein DUF3262 PF11660.8 EGD97880.1 - 0.1 13.0 2.7 0.25 11.8 0.1 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF3262) tRNA-synt_1e PF01406.19 EGD97881.1 - 5.7e-28 98.1 0.0 7.5e-28 97.7 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain Pkinase PF00069.25 EGD97883.1 - 3.3e-14 52.9 0.0 5.5e-13 48.9 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD97883.1 - 4.7e-12 45.8 0.0 3.1e-10 39.8 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Atg8 PF02991.16 EGD97886.1 - 1.9e-34 117.9 0.0 2.2e-34 117.7 0.0 1.0 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like APG12 PF04110.13 EGD97886.1 - 0.0021 18.4 0.0 0.0027 18.1 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 Peptidase_S10 PF00450.22 EGD97887.1 - 2.7e-92 310.4 0.0 3.4e-92 310.1 0.0 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase Abhydrolase_6 PF12697.7 EGD97887.1 - 0.11 13.0 0.0 13 6.4 0.0 2.3 2 0 0 2 2 2 0 Alpha/beta hydrolase family Methyltransf_16 PF10294.9 EGD97888.1 - 2.9e-13 49.9 0.0 3.9e-13 49.5 0.0 1.2 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_23 PF13489.6 EGD97888.1 - 0.00046 20.1 0.0 0.00063 19.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain GidB PF02527.15 EGD97888.1 - 0.0034 16.7 0.0 0.0058 16.0 0.0 1.3 1 0 0 1 1 1 1 rRNA small subunit methyltransferase G NNMT_PNMT_TEMT PF01234.17 EGD97888.1 - 0.037 13.2 0.0 0.06 12.5 0.0 1.3 1 0 0 1 1 1 0 NNMT/PNMT/TEMT family PrmA PF06325.13 EGD97888.1 - 0.038 13.4 0.0 0.066 12.6 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.6 EGD97888.1 - 0.066 13.9 0.0 0.21 12.3 0.0 1.8 1 1 0 1 1 1 0 Methyltransferase domain Gpi1 PF05024.15 EGD97889.1 - 0.018 15.1 0.0 0.022 14.9 0.0 1.1 1 0 0 1 1 1 0 N-acetylglucosaminyl transferase component (Gpi1) BAT2_N PF07001.11 EGD97889.1 - 0.55 10.7 8.6 0.58 10.6 8.6 1.1 1 0 0 1 1 1 0 BAT2 N-terminus MFS_1 PF07690.16 EGD97890.1 - 2.1e-38 132.2 32.4 7.3e-36 123.8 22.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EGD97890.1 - 2.1e-08 33.5 9.6 2.1e-08 33.5 9.6 2.6 2 1 0 2 2 2 1 Sugar (and other) transporter OATP PF03137.20 EGD97890.1 - 0.0002 19.8 4.9 0.0043 15.4 0.0 3.0 2 1 1 3 3 3 2 Organic Anion Transporter Polypeptide (OATP) family MFS_4 PF06779.14 EGD97890.1 - 0.00072 18.9 26.9 0.025 13.9 4.8 3.5 2 2 0 3 3 3 2 Uncharacterised MFS-type transporter YbfB MFS_1_like PF12832.7 EGD97890.1 - 0.13 11.1 20.4 0.068 12.0 4.0 3.6 2 2 1 3 3 3 0 MFS_1 like family F-box PF00646.33 EGD97892.1 - 0.0096 15.8 0.0 0.022 14.6 0.0 1.6 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EGD97892.1 - 0.056 13.3 0.0 0.15 12.0 0.0 1.7 1 0 0 1 1 1 0 F-box-like AlaDh_PNT_N PF05222.15 EGD97893.1 - 1.3e-27 96.7 0.0 2.1e-27 96.1 0.0 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain AlaDh_PNT_C PF01262.21 EGD97893.1 - 0.00066 19.0 0.0 0.0012 18.2 0.0 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain BAR PF03114.18 EGD97894.1 - 1.2e-66 224.8 7.7 1.5e-66 224.5 7.7 1.1 1 0 0 1 1 1 1 BAR domain SH3_1 PF00018.28 EGD97894.1 - 3.9e-13 48.8 0.0 8.1e-13 47.8 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EGD97894.1 - 1e-11 44.5 0.0 1.8e-11 43.7 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EGD97894.1 - 2.2e-07 30.4 0.1 6.6e-07 28.9 0.0 1.8 2 0 0 2 2 2 1 Variant SH3 domain Vps5 PF09325.10 EGD97894.1 - 0.11 12.1 5.4 3.3 7.2 2.2 2.2 2 0 0 2 2 2 0 Vps5 C terminal like BAR_3 PF16746.5 EGD97894.1 - 0.5 10.0 10.1 2.1 8.0 10.1 2.2 1 1 0 1 1 1 0 BAR domain of APPL family TMPIT PF07851.13 EGD97894.1 - 0.75 9.0 8.7 1.2 8.3 0.2 2.1 1 1 1 2 2 2 0 TMPIT-like protein APG6_N PF17675.1 EGD97894.1 - 2.6 8.6 10.8 12 6.4 5.0 2.4 2 0 0 2 2 2 0 Apg6 coiled-coil region BRE1 PF08647.11 EGD97894.1 - 3.2 7.9 12.1 0.97 9.5 0.6 2.5 2 0 0 2 2 2 0 BRE1 E3 ubiquitin ligase Asp PF00026.23 EGD97895.1 - 3.6e-61 207.3 5.4 4.4e-61 207.0 5.4 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EGD97895.1 - 5.2e-06 26.8 2.5 0.0025 18.1 1.2 3.2 2 1 0 2 2 2 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 EGD97895.1 - 0.0014 19.2 0.9 1.3 9.7 0.3 3.1 2 1 0 2 2 2 2 Aspartyl protease TAXi_C PF14541.6 EGD97895.1 - 0.0031 17.3 0.0 0.0088 15.8 0.0 1.8 1 0 0 1 1 1 1 Xylanase inhibitor C-terminal AvrPphF-ORF-2 PF09143.10 EGD97895.1 - 0.074 13.0 0.1 0.13 12.2 0.1 1.3 1 0 0 1 1 1 0 AvrPphF-ORF-2 GST_N PF02798.20 EGD97896.1 - 5.3e-17 61.9 0.0 1.1e-16 60.9 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 EGD97896.1 - 7.6e-17 61.5 0.0 2e-16 60.1 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EGD97896.1 - 4.5e-10 39.7 0.0 9e-10 38.7 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EGD97896.1 - 1.3e-09 38.1 0.0 2e-09 37.6 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EGD97896.1 - 0.00019 21.5 0.0 0.00027 21.1 0.0 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain ERG4_ERG24 PF01222.17 EGD97897.1 - 1.2e-93 314.2 16.0 1.4e-93 314.0 16.0 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family DUF1295 PF06966.12 EGD97897.1 - 0.006 16.1 0.4 0.013 15.0 0.4 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) Abhydrolase_6 PF12697.7 EGD97898.1 - 0.00022 21.9 0.1 0.0004 21.0 0.1 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family AAA_16 PF13191.6 EGD97898.1 - 0.0056 17.1 0.1 0.022 15.2 0.0 2.0 2 0 0 2 2 2 1 AAA ATPase domain ATPase PF06745.13 EGD97898.1 - 0.091 12.1 0.0 0.19 11.0 0.0 1.5 1 0 0 1 1 1 0 KaiC ATP_transf PF09830.9 EGD97899.1 - 2.8e-15 56.2 1.0 3.7e-15 55.8 0.1 1.7 2 0 0 2 2 2 1 ATP adenylyltransferase Copper-bind PF00127.20 EGD97900.1 - 0.00049 20.5 0.1 0.00083 19.8 0.1 1.3 1 0 0 1 1 1 1 Copper binding proteins, plastocyanin/azurin family Cas_csx3 PF09620.10 EGD97900.1 - 0.011 15.6 0.0 0.017 15.0 0.0 1.3 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_csx3) LEA_6 PF10714.9 EGD97900.1 - 0.018 15.1 1.5 0.03 14.4 1.5 1.4 1 0 0 1 1 1 0 Late embryogenesis abundant protein 18 Cupredoxin_1 PF13473.6 EGD97900.1 - 0.073 13.2 0.2 0.33 11.1 0.2 1.9 1 1 1 2 2 2 0 Cupredoxin-like domain Aminotran_5 PF00266.19 EGD97901.1 - 2.2e-94 316.4 0.0 2.7e-94 316.2 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 EGD97901.1 - 5.3e-07 29.2 0.0 7.9e-07 28.6 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.17 EGD97901.1 - 8.9e-06 25.2 0.0 5.7e-05 22.6 0.1 2.1 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Pyridoxal_deC PF00282.19 EGD97901.1 - 0.0047 15.7 0.0 0.007 15.1 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Cys_Met_Meta_PP PF01053.20 EGD97901.1 - 0.09 11.3 0.0 0.13 10.7 0.0 1.2 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme IDO PF01231.18 EGD97902.1 - 4.2e-153 510.2 0.0 4.9e-153 510.0 0.0 1.0 1 0 0 1 1 1 1 Indoleamine 2,3-dioxygenase UEV PF05743.13 EGD97903.1 - 4.6e-36 123.3 0.0 7.6e-36 122.6 0.0 1.4 1 0 0 1 1 1 1 UEV domain Vps23_core PF09454.10 EGD97903.1 - 3.4e-21 75.0 0.0 1.6e-20 72.8 0.0 2.0 2 0 0 2 2 2 1 Vps23 core domain ADIP PF11559.8 EGD97903.1 - 0.0022 18.1 1.7 0.0035 17.4 1.7 1.2 1 0 0 1 1 1 1 Afadin- and alpha -actinin-Binding CENP-Q PF13094.6 EGD97903.1 - 0.031 14.5 0.0 0.069 13.4 0.0 1.5 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit AAA_13 PF13166.6 EGD97903.1 - 0.11 11.1 0.1 0.15 10.7 0.1 1.1 1 0 0 1 1 1 0 AAA domain TPR_MLP1_2 PF07926.12 EGD97903.1 - 0.22 11.6 0.8 4.4 7.4 0.1 2.2 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein Spidroin_N PF16763.5 EGD97903.1 - 0.24 11.4 0.9 0.44 10.6 0.9 1.3 1 0 0 1 1 1 0 Major ampullate spidroin 1, spider silk protein 1, N-term WD40 PF00400.32 EGD97904.1 - 1.2e-12 48.1 11.7 0.0074 17.1 0.0 5.7 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EGD97904.1 - 1.8e-10 40.9 0.0 0.057 13.7 0.0 4.8 3 1 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EGD97904.1 - 0.0023 17.0 0.8 1.3 7.9 0.0 3.6 1 1 2 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Pro_CA PF00484.19 EGD97907.1 - 1e-43 149.3 0.1 1.4e-43 148.9 0.1 1.2 1 0 0 1 1 1 1 Carbonic anhydrase Velvet PF11754.8 EGD97910.1 - 2.4e-47 162.0 0.7 4.2e-33 115.3 0.2 3.3 2 1 2 4 4 4 2 Velvet factor MOZ_SAS PF01853.18 EGD97912.1 - 9e-75 250.3 0.0 1.4e-74 249.6 0.0 1.2 1 0 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 EGD97912.1 - 1.9e-21 75.4 3.4 4.6e-21 74.2 3.4 1.6 1 0 0 1 1 1 1 MYST family zinc finger domain PHD_4 PF16866.5 EGD97912.1 - 8.7e-09 35.3 13.0 2.8e-08 33.7 13.0 2.0 1 0 0 1 1 1 1 PHD-finger PHD PF00628.29 EGD97912.1 - 0.012 15.5 12.5 0.012 15.5 12.5 2.2 2 0 0 2 2 2 0 PHD-finger PHD_2 PF13831.6 EGD97912.1 - 0.024 14.2 7.1 0.021 14.4 4.8 2.2 2 0 0 2 2 2 0 PHD-finger zf-Sec23_Sec24 PF04810.15 EGD97912.1 - 0.25 11.4 5.3 1.1 9.4 2.1 2.9 2 0 0 2 2 2 0 Sec23/Sec24 zinc finger MWFE PF15879.5 EGD97913.1 - 6e-23 80.8 0.0 7.8e-23 80.4 0.0 1.2 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase MWFE subunit Acetyltransf_2 PF00797.17 EGD97914.1 - 2.8e-40 138.6 0.0 3.9e-40 138.1 0.0 1.1 1 0 0 1 1 1 1 N-acetyltransferase RraA-like PF03737.15 EGD97915.1 - 5.4e-31 107.8 0.0 6.9e-31 107.4 0.0 1.1 1 0 0 1 1 1 1 Aldolase/RraA NTP_transf_3 PF12804.7 EGD97915.1 - 0.077 13.3 0.1 0.44 10.9 0.0 1.9 1 1 1 2 2 2 0 MobA-like NTP transferase domain Thiolase_N PF00108.23 EGD97916.1 - 1.9e-73 247.0 2.8 3.3e-73 246.3 2.0 1.7 2 0 0 2 2 2 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 EGD97916.1 - 5.6e-44 148.7 0.2 1.1e-43 147.8 0.2 1.5 1 0 0 1 1 1 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 EGD97916.1 - 0.027 14.0 0.5 0.14 11.7 0.3 2.2 2 0 0 2 2 2 0 Beta-ketoacyl synthase, N-terminal domain GFO_IDH_MocA PF01408.22 EGD97918.1 - 5.9e-20 72.3 0.2 1.3e-19 71.2 0.1 1.6 2 0 0 2 2 2 1 Oxidoreductase family, NAD-binding Rossmann fold APH PF01636.23 EGD97919.1 - 1.3e-08 35.1 0.1 4.8e-08 33.2 0.1 1.8 1 1 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EGD97919.1 - 5.8e-06 26.0 0.0 9.4e-06 25.4 0.0 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase Kdo PF06293.14 EGD97919.1 - 0.1 11.9 0.0 0.3 10.4 0.0 1.7 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Drf_GBD PF06371.13 EGD97920.1 - 4.9e-19 68.6 5.6 5.9e-17 61.8 5.6 2.5 1 1 0 1 1 1 1 Diaphanous GTPase-binding Domain Snf7 PF03357.21 EGD97921.1 - 8.4e-44 149.2 12.8 1e-43 148.9 12.8 1.1 1 0 0 1 1 1 1 Snf7 DUF3584 PF12128.8 EGD97921.1 - 0.00032 18.4 4.8 0.00044 17.9 4.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) Atg14 PF10186.9 EGD97921.1 - 0.00077 18.6 1.6 0.00095 18.3 1.6 1.1 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 CLZ PF16526.5 EGD97921.1 - 0.0014 18.9 2.1 0.47 10.8 0.0 3.4 2 1 1 3 3 3 1 C-terminal leucine zipper domain of cyclic nucleotide-gated channels NPV_P10 PF05531.12 EGD97921.1 - 0.012 16.1 5.5 0.41 11.1 2.0 2.6 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein DUF4201 PF13870.6 EGD97921.1 - 0.012 15.3 7.3 0.013 15.3 4.3 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4201) HsbA PF12296.8 EGD97921.1 - 0.069 13.6 0.3 0.38 11.2 0.3 2.0 1 1 1 2 2 2 0 Hydrophobic surface binding protein A Alpha-2-MRAP_C PF06401.11 EGD97921.1 - 0.095 12.7 2.3 0.16 11.9 1.0 1.9 1 1 1 2 2 2 0 Alpha-2-macroglobulin RAP, C-terminal domain DUF948 PF06103.11 EGD97921.1 - 0.13 12.5 0.6 0.66 10.3 0.6 2.0 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) FlaC_arch PF05377.11 EGD97921.1 - 0.26 11.7 5.0 33 5.0 0.8 3.3 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) ABC_tran_CTD PF16326.5 EGD97921.1 - 0.3 11.4 6.4 0.57 10.5 0.1 3.2 2 2 0 2 2 2 0 ABC transporter C-terminal domain Vps51 PF08700.11 EGD97921.1 - 1.6 8.9 6.3 2.7 8.1 0.6 3.1 2 1 1 3 3 3 0 Vps51/Vps67 DASH_Dam1 PF08653.10 EGD97921.1 - 1.8 8.4 3.6 22 5.0 0.3 3.1 3 0 0 3 3 3 0 DASH complex subunit Dam1 DUF4094 PF13334.6 EGD97921.1 - 2.8 8.4 5.0 12 6.4 0.0 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4094) SlyX PF04102.12 EGD97921.1 - 5.6 7.7 10.4 11 6.7 1.7 3.6 1 1 2 3 3 3 0 SlyX SAPS PF04499.15 EGD97922.1 - 3.4e-179 596.7 0.1 3.4e-179 596.7 0.1 2.3 3 0 0 3 3 3 1 SIT4 phosphatase-associated protein SET PF00856.28 EGD97923.1 - 0.0021 18.5 0.0 0.0047 17.3 0.0 1.6 1 0 0 1 1 1 1 SET domain Complex1_51K PF01512.17 EGD97924.1 - 1.3e-38 132.2 0.0 2.4e-38 131.4 0.0 1.4 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase 51 Kd subunit NADH_4Fe-4S PF10589.9 EGD97924.1 - 2.8e-29 101.0 2.0 3.7e-29 100.6 0.3 2.0 2 0 0 2 2 2 1 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region SLBB PF10531.9 EGD97924.1 - 9.5e-09 35.0 0.0 2.5e-08 33.6 0.0 1.8 1 0 0 1 1 1 1 SLBB domain Nup96 PF12110.8 EGD97925.1 - 1.1e-76 257.8 0.0 1.6e-76 257.2 0.0 1.3 1 0 0 1 1 1 1 Nuclear protein 96 Nucleoporin2 PF04096.14 EGD97925.1 - 4.5e-52 176.1 0.0 8.4e-52 175.2 0.0 1.5 1 0 0 1 1 1 1 Nucleoporin autopeptidase Nucleoporin_FG PF13634.6 EGD97925.1 - 3.4e-13 50.2 81.0 7.8e-11 42.7 43.4 11.3 5 3 4 9 9 9 2 Nucleoporin FG repeat region zf-C3Hc3H PF13891.6 EGD97926.1 - 0.054 13.9 2.9 0.11 12.8 2.4 1.8 1 1 0 1 1 1 0 Potential DNA-binding domain AMP-binding PF00501.28 EGD97927.1 - 2.3e-92 309.8 0.1 3e-92 309.4 0.1 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EGD97927.1 - 2.4e-27 95.7 2.2 1.5e-25 90.0 1.7 2.8 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain ACAS_N PF16177.5 EGD97927.1 - 2.3e-15 56.2 0.1 6.2e-15 54.9 0.1 1.8 1 0 0 1 1 1 1 Acetyl-coenzyme A synthetase N-terminus GET2 PF08690.10 EGD97928.1 - 3.5e-09 36.8 0.0 5.8e-09 36.1 0.0 1.4 1 1 0 1 1 1 1 GET complex subunit GET2 HTH_24 PF13412.6 EGD97928.1 - 0.053 13.1 0.0 0.31 10.6 0.0 2.2 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding C2 PF00168.30 EGD97929.1 - 6.3e-29 100.3 0.0 1.1e-16 61.0 0.0 2.5 2 0 0 2 2 2 2 C2 domain IMS PF00817.20 EGD97932.1 - 4.7e-40 137.0 0.0 7.8e-40 136.3 0.0 1.4 1 0 0 1 1 1 1 impB/mucB/samB family IMS_C PF11799.8 EGD97932.1 - 1.5e-16 61.2 0.0 1.1e-15 58.4 0.1 2.1 2 0 0 2 2 2 1 impB/mucB/samB family C-terminal domain IMS_HHH PF11798.8 EGD97932.1 - 0.11 12.8 0.0 0.69 10.4 0.0 2.3 2 0 0 2 2 2 0 IMS family HHH motif Reprolysin_5 PF13688.6 EGD97934.1 - 2.8e-58 197.3 6.7 2.8e-58 197.3 6.7 1.9 2 0 0 2 2 2 1 Metallo-peptidase family M12 Reprolysin_2 PF13574.6 EGD97934.1 - 3.3e-46 157.7 1.6 7.4e-46 156.5 1.6 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 EGD97934.1 - 6.7e-43 146.7 1.6 1.2e-42 145.8 1.6 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Disintegrin PF00200.23 EGD97934.1 - 2e-14 54.1 34.9 2e-14 54.1 34.9 4.3 3 1 1 4 4 4 1 Disintegrin Reprolysin_3 PF13582.6 EGD97934.1 - 3e-11 43.9 0.0 7.8e-11 42.6 0.0 1.8 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like ADAM_CR_2 PF17771.1 EGD97934.1 - 7.6e-07 29.6 1.6 7.6e-07 29.6 1.6 5.2 2 1 4 6 6 6 1 ADAM cysteine-rich domain Pep_M12B_propep PF01562.19 EGD97934.1 - 0.013 15.7 0.1 0.025 14.8 0.1 1.4 1 0 0 1 1 1 0 Reprolysin family propeptide EF-hand_7 PF13499.6 EGD97935.1 - 1.9e-10 41.0 0.5 4.5e-10 39.8 0.1 1.7 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_8 PF13833.6 EGD97935.1 - 5.1e-09 35.8 0.2 1.1e-08 34.8 0.2 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 EGD97935.1 - 4.2e-07 29.1 0.7 0.0005 19.4 0.1 2.7 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 EGD97935.1 - 4e-06 26.3 1.2 5.4e-05 22.8 0.1 2.8 3 1 0 3 3 3 1 EF-hand domain MgsA_C PF12002.8 EGD97936.1 - 2.1e-58 197.0 0.1 3.5e-58 196.2 0.1 1.3 1 0 0 1 1 1 1 MgsA AAA+ ATPase C terminal AAA_assoc_2 PF16193.5 EGD97936.1 - 3e-24 85.2 0.6 6.6e-24 84.1 0.6 1.6 1 0 0 1 1 1 1 AAA C-terminal domain AAA PF00004.29 EGD97936.1 - 5.3e-14 52.8 0.0 1.2e-13 51.7 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 EGD97936.1 - 2.2e-11 43.7 0.0 4.4e-11 42.8 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain Mg_chelatase PF01078.21 EGD97936.1 - 9.7e-06 25.1 0.2 0.044 13.2 0.0 2.3 1 1 1 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 EGD97936.1 - 4.2e-05 23.6 0.0 0.0013 18.7 0.0 2.5 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 EGD97936.1 - 7e-05 22.6 0.0 0.0037 17.0 0.0 2.3 1 1 0 1 1 1 1 Sigma-54 interaction domain AAA_16 PF13191.6 EGD97936.1 - 0.00011 22.7 0.3 0.038 14.4 0.1 2.9 2 1 1 3 3 3 1 AAA ATPase domain AAA_3 PF07726.11 EGD97936.1 - 0.00035 20.5 0.0 0.00091 19.1 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EGD97936.1 - 0.00093 19.5 0.1 0.0039 17.5 0.1 2.0 1 1 0 1 1 1 1 AAA domain DUF815 PF05673.13 EGD97936.1 - 0.0014 17.8 0.0 0.0022 17.2 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_14 PF13173.6 EGD97936.1 - 0.0021 18.1 0.0 0.004 17.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain ResIII PF04851.15 EGD97936.1 - 0.0058 16.7 0.1 0.51 10.3 0.0 2.3 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit TsaE PF02367.17 EGD97936.1 - 0.018 15.1 0.0 0.036 14.1 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_30 PF13604.6 EGD97936.1 - 0.021 14.5 0.2 0.081 12.6 0.2 2.0 1 1 0 1 1 1 0 AAA domain TIP49 PF06068.13 EGD97936.1 - 0.028 13.6 0.1 0.054 12.7 0.1 1.3 1 1 0 1 1 1 0 TIP49 P-loop domain Sigma54_activ_2 PF14532.6 EGD97936.1 - 0.036 14.2 0.0 0.076 13.1 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain PIF1 PF05970.14 EGD97936.1 - 0.037 13.2 0.0 0.072 12.2 0.0 1.4 1 0 0 1 1 1 0 PIF1-like helicase NACHT PF05729.12 EGD97936.1 - 0.064 13.2 0.1 0.16 11.9 0.1 1.6 1 0 0 1 1 1 0 NACHT domain AAA_29 PF13555.6 EGD97936.1 - 0.076 12.8 0.1 5.1 6.9 0.1 2.4 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_24 PF13479.6 EGD97936.1 - 0.094 12.4 0.0 0.15 11.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.22 EGD97936.1 - 0.1 11.7 0.0 0.17 11.0 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain RNA_helicase PF00910.22 EGD97936.1 - 0.11 12.9 0.0 0.21 12.0 0.0 1.5 1 0 0 1 1 1 0 RNA helicase AAA_18 PF13238.6 EGD97936.1 - 0.12 12.9 0.0 0.24 12.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 EGD97936.1 - 0.15 12.0 0.0 3.5 7.5 0.0 2.3 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_19 PF13245.6 EGD97936.1 - 0.15 12.4 0.2 0.53 10.6 0.2 2.0 1 1 0 1 1 1 0 AAA domain AAA_13 PF13166.6 EGD97936.1 - 0.2 10.3 0.1 0.39 9.3 0.1 1.4 1 0 0 1 1 1 0 AAA domain Aminotran_1_2 PF00155.21 EGD97937.1 - 2.2e-70 237.7 0.0 2.5e-70 237.5 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 EGD97937.1 - 0.00012 21.4 0.0 0.00019 20.8 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_5 PF00266.19 EGD97937.1 - 0.00022 20.3 0.1 0.0026 16.8 0.1 2.0 1 1 0 1 1 1 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 EGD97937.1 - 0.00045 18.9 0.0 0.001 17.7 0.0 1.6 1 1 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 EGD97937.1 - 0.042 13.2 0.0 0.091 12.0 0.0 1.6 1 1 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family KH_1 PF00013.29 EGD97938.1 - 1.7e-47 159.1 8.0 1.5e-15 56.8 0.4 3.3 3 0 0 3 3 3 3 KH domain KH_2 PF07650.17 EGD97938.1 - 6.6e-13 48.3 2.3 0.00074 19.3 0.1 3.4 3 0 0 3 3 3 3 KH domain KH_4 PF13083.6 EGD97938.1 - 4.3e-10 39.3 3.9 0.014 15.3 0.0 3.5 3 0 0 3 3 3 3 KH domain KH_5 PF13184.6 EGD97938.1 - 0.0045 17.0 3.1 7.1 6.8 0.1 3.3 3 0 0 3 3 3 2 NusA-like KH domain Amidoligase_2 PF12224.8 EGD97939.1 - 9.2e-14 51.7 0.0 1.4e-13 51.1 0.0 1.3 1 0 0 1 1 1 1 Putative amidoligase enzyme DUF3517 PF12030.8 EGD97939.1 - 0.12 11.2 0.1 0.27 10.1 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3517) DUF3665 PF12427.8 EGD97940.1 - 0.00011 21.8 0.2 0.64 9.8 0.0 2.5 2 0 0 2 2 2 2 Branched-chain amino acid aminotransferase HHH_3 PF12836.7 EGD97940.1 - 0.065 13.5 0.0 21 5.4 0.0 2.7 3 0 0 3 3 3 0 Helix-hairpin-helix motif Ald_Xan_dh_C2 PF02738.18 EGD97942.1 - 2.5e-205 683.1 0.4 3.6e-205 682.6 0.4 1.1 1 0 0 1 1 1 1 Molybdopterin-binding domain of aldehyde dehydrogenase FAD_binding_5 PF00941.21 EGD97942.1 - 5.6e-45 153.1 0.0 1.1e-44 152.2 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain in molybdopterin dehydrogenase CO_deh_flav_C PF03450.17 EGD97942.1 - 4.9e-34 116.6 0.0 1.9e-33 114.7 0.0 2.1 2 0 0 2 2 2 1 CO dehydrogenase flavoprotein C-terminal domain Ald_Xan_dh_C PF01315.22 EGD97942.1 - 3.9e-29 101.2 0.0 8.8e-29 100.1 0.0 1.7 1 0 0 1 1 1 1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain Fer2_2 PF01799.20 EGD97942.1 - 3.4e-28 97.5 0.0 8.3e-28 96.2 0.0 1.7 1 0 0 1 1 1 1 [2Fe-2S] binding domain Fer2 PF00111.27 EGD97942.1 - 5.6e-09 35.8 0.5 1.5e-08 34.5 0.1 2.0 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain PDGF PF00341.17 EGD97942.1 - 0.17 12.2 0.3 0.48 10.8 0.3 1.7 1 0 0 1 1 1 0 PDGF/VEGF domain NAD_binding_4 PF07993.12 EGD97943.1 - 2.2e-72 243.3 0.0 3.2e-72 242.8 0.0 1.2 1 0 0 1 1 1 1 Male sterility protein AMP-binding PF00501.28 EGD97943.1 - 1.9e-70 237.6 0.0 2.7e-70 237.1 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme Epimerase PF01370.21 EGD97943.1 - 9e-11 41.7 0.0 2.2e-10 40.4 0.0 1.6 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Condensation PF00668.20 EGD97943.1 - 7.9e-09 34.7 0.1 5.5e-08 31.9 0.1 2.1 1 1 0 1 1 1 1 Condensation domain PP-binding PF00550.25 EGD97943.1 - 1.5e-08 34.9 0.0 3.4e-08 33.7 0.0 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site 3Beta_HSD PF01073.19 EGD97943.1 - 0.00014 20.9 0.0 0.00039 19.5 0.0 1.7 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family AMP-binding_C PF13193.6 EGD97943.1 - 0.00099 20.0 0.0 0.0037 18.2 0.0 2.1 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain NAD_binding_10 PF13460.6 EGD97943.1 - 0.0021 18.0 0.0 0.052 13.4 0.0 2.5 1 1 0 1 1 1 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 EGD97943.1 - 0.021 14.2 0.0 0.034 13.5 0.0 1.3 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase DUF769 PF05590.11 EGD97943.1 - 0.09 12.2 0.1 0.2 11.1 0.0 1.5 2 0 0 2 2 2 0 Xylella fastidiosa protein of unknown function (DUF769) RmlD_sub_bind PF04321.17 EGD97943.1 - 0.097 11.8 0.0 0.42 9.7 0.0 2.0 2 0 0 2 2 2 0 RmlD substrate binding domain PRK PF00485.18 EGD97944.1 - 0.00021 21.1 0.0 0.00031 20.5 0.0 1.3 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family ABC_tran PF00005.27 EGD97944.1 - 0.00034 21.1 0.0 0.00049 20.6 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_16 PF13191.6 EGD97944.1 - 0.0055 17.1 0.0 0.0091 16.4 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_18 PF13238.6 EGD97944.1 - 0.02 15.4 0.0 0.05 14.1 0.0 1.9 1 1 0 1 1 1 0 AAA domain AAA_28 PF13521.6 EGD97944.1 - 0.055 13.7 0.2 0.13 12.5 0.1 1.6 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 EGD97944.1 - 0.13 12.6 0.1 0.61 10.4 0.1 1.9 1 1 0 1 1 1 0 AAA domain AAA_29 PF13555.6 EGD97944.1 - 0.14 11.9 0.2 0.29 10.9 0.2 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain SNF2_N PF00176.23 EGD97945.1 - 6.4e-37 127.1 0.0 1.6e-33 115.9 0.0 2.4 3 0 0 3 3 3 2 SNF2 family N-terminal domain Helicase_C PF00271.31 EGD97945.1 - 1.7e-08 34.7 0.0 9.8e-08 32.3 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HMG_box PF00505.19 EGD97946.1 - 1.9e-21 76.2 0.1 3.7e-21 75.3 0.1 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EGD97946.1 - 2e-05 25.1 0.0 4.2e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 HMG-box domain Ribosomal_S6e PF01092.19 EGD97947.1 - 5.3e-34 116.9 0.1 9.2e-30 103.2 0.1 2.6 1 1 1 2 2 2 2 Ribosomal protein S6e Pribosyltran_N PF13793.6 EGD97948.1 - 1.9e-47 160.0 0.3 6.2e-45 151.9 0.1 2.4 2 0 0 2 2 2 2 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.6 EGD97948.1 - 5.4e-44 150.4 1.0 4.4e-37 127.9 0.4 2.5 1 1 1 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.27 EGD97948.1 - 8.2e-19 67.7 0.5 9.3e-18 64.3 0.3 2.1 2 0 0 2 2 2 1 Phosphoribosyl transferase domain UPRTase PF14681.6 EGD97948.1 - 0.002 17.6 0.1 0.004 16.6 0.1 1.5 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase DUF913 PF06025.12 EGD97949.1 - 2.4e-126 421.7 0.0 2.4e-126 421.7 0.0 6.0 5 2 0 5 5 5 2 Domain of Unknown Function (DUF913) DUF908 PF06012.12 EGD97949.1 - 1.5e-110 370.0 6.7 1.5e-110 370.0 6.7 4.1 5 0 0 5 5 5 1 Domain of Unknown Function (DUF908) HECT PF00632.25 EGD97949.1 - 6.6e-94 314.8 0.0 1.9e-93 313.3 0.0 1.7 2 0 0 2 2 2 1 HECT-domain (ubiquitin-transferase) UBM PF14377.6 EGD97949.1 - 5.1e-30 102.0 21.6 4.6e-10 38.6 3.2 4.4 3 0 0 3 3 3 3 Ubiquitin binding region UBA PF00627.31 EGD97949.1 - 0.00074 19.4 0.0 0.0025 17.7 0.0 1.9 1 0 0 1 1 1 1 UBA/TS-N domain An_peroxidase PF03098.15 EGD97950.1 - 6.4e-37 127.3 0.0 1.9e-24 86.1 0.0 3.3 1 1 1 2 2 2 2 Animal haem peroxidase p450 PF00067.22 EGD97950.1 - 2.8e-09 36.3 0.0 3.5e-07 29.4 0.0 2.1 2 0 0 2 2 2 2 Cytochrome P450 Steroid_dh PF02544.16 EGD97952.1 - 3e-31 108.4 0.2 3.9e-31 108.1 0.2 1.1 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase DUF1295 PF06966.12 EGD97952.1 - 2.6e-06 27.2 0.3 3.3e-06 26.8 0.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) PEMT PF04191.13 EGD97952.1 - 6.4e-05 23.3 0.3 0.00014 22.2 0.3 1.6 1 0 0 1 1 1 1 Phospholipid methyltransferase Glyco_transf_34 PF05637.12 EGD97953.1 - 4.6e-58 196.7 0.0 5.7e-58 196.5 0.0 1.1 1 0 0 1 1 1 1 galactosyl transferase GMA12/MNN10 family Ribosomal_L28 PF00830.19 EGD97954.1 - 4.1e-16 58.9 0.7 7.5e-16 58.1 0.7 1.4 1 0 0 1 1 1 1 Ribosomal L28 family TIP49 PF06068.13 EGD97955.1 - 3.8e-166 552.6 0.1 4.5e-166 552.3 0.1 1.0 1 0 0 1 1 1 1 TIP49 P-loop domain TIP49_C PF17856.1 EGD97955.1 - 6.9e-21 74.2 0.1 3.3e-20 72.0 0.0 2.2 2 0 0 2 2 2 1 TIP49 AAA-lid domain AAA PF00004.29 EGD97955.1 - 1.9e-11 44.5 0.3 2.6e-07 31.1 0.1 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 EGD97955.1 - 9.7e-10 38.4 0.1 2.7e-06 27.2 0.0 2.4 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EGD97955.1 - 9.6e-06 25.9 0.1 0.047 13.9 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.6 EGD97955.1 - 9.8e-05 22.7 0.2 0.066 13.5 0.0 2.3 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 EGD97955.1 - 0.00017 22.1 0.2 0.0034 17.8 0.2 2.3 1 1 0 1 1 1 1 AAA ATPase domain AAA_28 PF13521.6 EGD97955.1 - 0.00036 20.8 0.2 0.001 19.3 0.1 1.8 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.14 EGD97955.1 - 0.00087 19.3 0.2 0.23 11.5 0.0 2.5 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 EGD97955.1 - 0.0015 18.3 0.0 1.4 8.6 0.0 2.4 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_17 PF13207.6 EGD97955.1 - 0.0039 17.6 0.1 0.062 13.7 0.0 2.4 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.12 EGD97955.1 - 0.0047 16.2 0.2 0.013 14.8 0.2 1.7 2 0 0 2 2 2 1 Zeta toxin AAA_25 PF13481.6 EGD97955.1 - 0.0071 15.9 0.1 0.015 14.9 0.1 1.5 1 0 0 1 1 1 1 AAA domain DnaB_C PF03796.15 EGD97955.1 - 0.0079 15.6 0.1 0.022 14.1 0.0 1.7 2 0 0 2 2 2 1 DnaB-like helicase C terminal domain ATPase PF06745.13 EGD97955.1 - 0.014 14.8 0.6 0.12 11.7 0.0 2.4 3 0 0 3 3 3 0 KaiC Mg_chelatase PF01078.21 EGD97955.1 - 0.017 14.5 0.1 0.8 9.0 0.0 2.3 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_14 PF13173.6 EGD97955.1 - 0.032 14.3 0.0 0.66 10.0 0.0 2.3 2 0 0 2 2 2 0 AAA domain TetR_C_30 PF17939.1 EGD97955.1 - 0.048 13.9 0.0 0.1 12.8 0.0 1.5 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain IstB_IS21 PF01695.17 EGD97955.1 - 0.051 13.3 0.0 0.1 12.3 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_18 PF13238.6 EGD97955.1 - 0.056 14.0 0.1 0.28 11.7 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 EGD97955.1 - 0.058 12.9 0.1 0.26 10.8 0.0 1.9 2 0 0 2 2 2 0 P-loop containing dynein motor region DUF2075 PF09848.9 EGD97955.1 - 0.067 12.4 0.0 0.12 11.6 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_30 PF13604.6 EGD97955.1 - 0.11 12.2 0.2 1.6 8.4 0.1 2.3 2 0 0 2 2 2 0 AAA domain V-SNARE PF05008.15 EGD97956.1 - 6.3e-23 81.0 7.2 6.3e-23 81.0 7.2 1.9 2 0 0 2 2 2 1 Vesicle transport v-SNARE protein N-terminus V-SNARE_C PF12352.8 EGD97956.1 - 2.3e-14 53.4 1.1 2.3e-14 53.4 1.1 2.8 3 1 0 3 3 3 1 Snare region anchored in the vesicle membrane C-terminus LMBR1 PF04791.16 EGD97956.1 - 0.0046 15.9 1.0 0.0053 15.7 1.0 1.0 1 0 0 1 1 1 1 LMBR1-like membrane protein Fusion_gly PF00523.18 EGD97956.1 - 0.039 12.2 1.0 1 7.6 0.1 2.3 2 0 0 2 2 2 0 Fusion glycoprotein F0 DUF1542 PF07564.11 EGD97956.1 - 0.13 12.4 6.1 0.16 12.1 3.8 2.1 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1542) FUSC PF04632.12 EGD97956.1 - 0.51 8.8 8.6 2.2 6.7 8.9 1.7 1 1 0 1 1 1 0 Fusaric acid resistance protein family DUF4355 PF14265.6 EGD97956.1 - 0.59 10.4 7.6 0.26 11.6 5.1 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4355) TBCA PF02970.16 EGD97956.1 - 1.3 9.4 7.7 0.73 10.2 2.6 2.6 2 1 0 2 2 2 0 Tubulin binding cofactor A zf-C4H2 PF10146.9 EGD97956.1 - 1.3 9.3 9.3 7.2 6.9 9.4 2.0 1 1 0 1 1 1 0 Zinc finger-containing protein Exonuc_VII_L PF02601.15 EGD97956.1 - 1.9 8.0 13.1 3.2 7.2 13.1 1.4 1 1 0 1 1 1 0 Exonuclease VII, large subunit DUF349 PF03993.12 EGD97956.1 - 3 8.2 10.9 4.7 7.6 0.3 2.5 1 1 1 2 2 2 0 Domain of Unknown Function (DUF349) V_ATPase_I PF01496.19 EGD97956.1 - 9.5 4.0 6.8 1.1 7.1 1.2 1.9 1 1 1 2 2 2 0 V-type ATPase 116kDa subunit family DUF2407_C PF13373.6 EGD97957.1 - 1.6e-42 145.0 0.1 2.5e-42 144.4 0.1 1.3 1 0 0 1 1 1 1 DUF2407 C-terminal domain DUF2407 PF10302.9 EGD97957.1 - 5e-39 133.1 0.0 7.5e-39 132.5 0.0 1.3 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain ubiquitin PF00240.23 EGD97957.1 - 0.018 14.8 0.0 0.031 14.0 0.0 1.3 1 0 0 1 1 1 0 Ubiquitin family Rad60-SLD_2 PF13881.6 EGD97957.1 - 0.036 14.2 0.0 0.065 13.3 0.0 1.3 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Fe-S_biosyn PF01521.20 EGD97958.1 - 5.7e-11 42.6 0.0 1.4e-09 38.1 0.0 2.8 2 1 1 3 3 3 1 Iron-sulphur cluster biosynthesis 2OG-Fe_Oxy_2 PF10014.9 EGD97959.1 - 1e-52 178.8 0.0 1.2e-52 178.5 0.0 1.1 1 0 0 1 1 1 1 2OG-Fe dioxygenase MFS_1 PF07690.16 EGD97960.1 - 3e-39 134.9 47.6 3e-39 134.9 47.6 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EGD97960.1 - 3.5e-14 52.5 8.4 3.5e-14 52.5 8.4 2.2 2 0 0 2 2 2 1 Sugar (and other) transporter DUF1741 PF08427.10 EGD97961.1 - 6.2e-85 284.6 0.3 1e-84 283.9 0.3 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1741) MRG PF05712.13 EGD97962.1 - 4.9e-60 202.2 0.1 7.1e-60 201.7 0.1 1.2 1 0 0 1 1 1 1 MRG Tudor-knot PF11717.8 EGD97962.1 - 8e-08 32.1 2.2 2e-07 30.8 2.2 1.6 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Cnl2_NKP2 PF09447.10 EGD97963.1 - 1.1e-27 96.0 3.7 1.8e-27 95.3 3.7 1.4 1 0 0 1 1 1 1 Cnl2/NKP2 family protein APG6_N PF17675.1 EGD97963.1 - 0.019 15.5 2.2 0.082 13.4 1.5 2.0 1 1 1 2 2 2 0 Apg6 coiled-coil region YabA PF06156.13 EGD97963.1 - 0.051 14.2 0.8 7.3 7.3 0.2 2.2 2 0 0 2 2 2 0 Initiation control protein YabA Mod_r PF07200.13 EGD97963.1 - 0.13 12.4 3.4 0.49 10.5 3.4 1.9 1 1 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein Ctf8 PF09696.10 EGD97965.1 - 3.3e-48 163.6 0.1 3.9e-48 163.4 0.1 1.0 1 0 0 1 1 1 1 Ctf8 Glyoxalase PF00903.25 EGD97966.1 - 8.3e-16 58.3 0.1 4.1e-14 52.9 0.0 2.4 2 1 0 2 2 2 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 EGD97966.1 - 2.3e-08 34.3 0.0 1.5e-05 25.2 0.0 3.0 2 2 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_3 PF13468.6 EGD97966.1 - 7.6e-05 22.9 0.0 0.91 9.6 0.0 3.4 2 2 1 3 3 3 2 Glyoxalase-like domain Pectinesterase PF01095.19 EGD97966.1 - 0.061 12.0 0.0 0.094 11.4 0.0 1.2 1 0 0 1 1 1 0 Pectinesterase RabGAP-TBC PF00566.18 EGD97967.1 - 1.1e-50 172.3 0.4 1.1e-50 172.3 0.4 2.9 2 1 0 2 2 2 1 Rab-GTPase-TBC domain Mago_nashi PF02792.14 EGD97967.1 - 1.3 9.2 4.2 0.39 10.8 0.4 1.9 1 1 1 2 2 2 0 Mago nashi protein PPTA PF01239.22 EGD97968.1 - 2.2e-38 128.9 9.1 1.9e-08 33.8 0.9 5.6 5 0 0 5 5 5 5 Protein prenyltransferase alpha subunit repeat APH PF01636.23 EGD97970.1 - 4.5e-16 59.5 0.3 7.2e-16 58.8 0.3 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EGD97970.1 - 6.7e-06 25.8 0.4 1.1e-05 25.2 0.4 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase Pkinase PF00069.25 EGD97970.1 - 0.0077 15.6 0.0 1.4 8.2 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain DUF1679 PF07914.11 EGD97970.1 - 0.076 11.9 0.1 5.1 5.9 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1679) WD40 PF00400.32 EGD97971.1 - 5.6e-10 39.6 3.9 6.6e-06 26.8 0.0 5.4 7 0 0 7 7 7 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EGD97971.1 - 5.4e-08 33.0 0.0 0.00064 20.0 0.0 3.9 4 0 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Utp12 PF04003.12 EGD97972.1 - 1.1e-22 80.4 0.5 7e-22 77.8 0.3 2.4 3 0 0 3 3 3 1 Dip2/Utp12 Family DUF212 PF02681.14 EGD97972.1 - 0.049 13.8 0.8 0.11 12.6 0.8 1.5 1 0 0 1 1 1 0 Divergent PAP2 family ANAPC4_WD40 PF12894.7 EGD97972.1 - 0.095 13.0 0.0 19 5.6 0.0 3.6 4 0 0 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain Bromodomain PF00439.25 EGD97974.1 - 1.6e-17 63.3 0.1 4.1e-16 58.8 0.0 2.3 2 0 0 2 2 2 1 Bromodomain zf-CSL PF05207.13 EGD97975.1 - 1.9e-21 75.6 0.1 2.3e-21 75.2 0.1 1.1 1 0 0 1 1 1 1 CSL zinc finger Frataxin_Cyay PF01491.16 EGD97976.1 - 6.8e-24 84.0 0.0 9.4e-24 83.6 0.0 1.2 1 0 0 1 1 1 1 Frataxin-like domain DUF1192 PF06698.11 EGD97976.1 - 0.21 11.7 1.2 0.49 10.5 1.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1192) AKAP7_NLS PF10469.9 EGD97977.1 - 3.2e-16 59.9 0.0 5.9e-16 59.0 0.0 1.4 1 1 0 1 1 1 1 AKAP7 2'5' RNA ligase-like domain Sec6 PF06046.13 EGD97979.1 - 2.7e-173 577.4 3.4 3.6e-173 577.0 3.4 1.2 1 0 0 1 1 1 1 Exocyst complex component Sec6 Mod_r PF07200.13 EGD97979.1 - 0.0021 18.2 0.1 0.0021 18.2 0.1 2.8 3 0 0 3 3 3 1 Modifier of rudimentary (Mod(r)) protein Ribosomal_L30 PF00327.20 EGD97980.1 - 4.1e-12 45.8 0.2 6e-12 45.3 0.2 1.3 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e Pyridoxal_deC PF00282.19 EGD97981.1 - 1.5e-12 47.0 0.0 2.9e-12 46.0 0.0 1.4 1 1 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain DegT_DnrJ_EryC1 PF01041.17 EGD97981.1 - 8.6e-06 25.3 0.0 1.4e-05 24.6 0.0 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_5 PF00266.19 EGD97981.1 - 2.2e-05 23.6 0.0 0.00013 21.1 0.0 1.9 2 0 0 2 2 2 1 Aminotransferase class-V Aminotran_1_2 PF00155.21 EGD97981.1 - 0.0022 17.2 0.0 0.0047 16.1 0.0 1.5 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 EGD97981.1 - 0.16 10.5 0.0 0.26 9.8 0.0 1.2 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme PKD_channel PF08016.12 EGD97981.1 - 0.22 10.2 0.1 0.31 9.7 0.1 1.1 1 0 0 1 1 1 0 Polycystin cation channel Aminotran_1_2 PF00155.21 EGD97982.1 - 5.3e-92 308.8 0.0 6e-92 308.6 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II DUF2140 PF09911.9 EGD97983.1 - 0.013 15.1 0.5 0.015 14.8 0.5 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2140) Lipoprotein_18 PF06804.11 EGD97983.1 - 0.095 11.7 7.5 0.1 11.6 7.5 1.0 1 0 0 1 1 1 0 NlpB/DapX lipoprotein SLC12 PF03522.15 EGD97983.1 - 0.6 9.1 8.4 0.68 8.9 8.4 1.0 1 0 0 1 1 1 0 Solute carrier family 12 O-antigen_lig PF13425.6 EGD97983.1 - 0.69 8.6 2.1 0.78 8.5 2.1 1.0 1 0 0 1 1 1 0 O-antigen ligase like membrane protein RR_TM4-6 PF06459.12 EGD97983.1 - 1.2 8.9 9.3 1.5 8.6 9.3 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Pannexin_like PF12534.8 EGD97983.1 - 5.6 5.9 7.2 6.1 5.8 7.2 1.0 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 Presenilin PF01080.17 EGD97983.1 - 9.7 4.8 9.7 10 4.8 9.7 1.0 1 0 0 1 1 1 0 Presenilin zf-C2H2 PF00096.26 EGD97984.1 - 3.2e-19 68.2 28.5 4.1e-05 23.8 1.8 5.1 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EGD97984.1 - 5.6e-17 61.3 25.2 1.5e-06 28.4 1.5 5.8 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2_jaz PF12171.8 EGD97984.1 - 0.00016 21.8 7.3 0.48 10.8 0.1 4.8 5 0 0 5 5 5 1 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 EGD97984.1 - 0.0012 19.5 11.1 0.0045 17.7 1.2 6.0 6 0 0 6 6 6 4 C2H2-type zinc finger zf-C2H2_aberr PF17017.5 EGD97984.1 - 0.025 14.7 2.2 3.2 7.9 0.1 2.4 2 0 0 2 2 2 0 Aberrant zinc-finger zf-C2H2_11 PF16622.5 EGD97984.1 - 0.028 14.2 0.7 0.028 14.2 0.7 3.4 3 0 0 3 3 3 0 zinc-finger C2H2-type zf-met PF12874.7 EGD97984.1 - 0.3 11.5 17.8 0.33 11.4 0.2 4.5 5 0 0 5 5 5 0 Zinc-finger of C2H2 type XPA_N PF01286.18 EGD97984.1 - 1.1 9.4 7.1 0.65 10.1 0.5 2.8 3 0 0 3 3 3 0 XPA protein N-terminal FOXP-CC PF16159.5 EGD97984.1 - 5.7 7.6 21.4 0.18 12.4 0.6 4.6 4 1 1 5 5 5 0 FOXP coiled-coil domain Methyltransf_23 PF13489.6 EGD97985.1 - 6.4e-19 68.4 0.0 9.7e-19 67.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EGD97985.1 - 3e-14 53.4 0.0 5.5e-14 52.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EGD97985.1 - 9.6e-12 45.5 0.0 1.9e-11 44.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EGD97985.1 - 2e-11 44.5 0.0 3.3e-11 43.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EGD97985.1 - 5.9e-09 35.9 0.0 8.5e-09 35.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 EGD97985.1 - 0.0011 18.3 0.0 0.22 10.8 0.0 2.2 2 0 0 2 2 2 2 Mycolic acid cyclopropane synthetase Caskin-Pro-rich PF16907.5 EGD97985.1 - 0.017 15.6 3.4 0.038 14.5 3.4 1.6 1 0 0 1 1 1 0 Proline rich region of Caskin proteins Methyltransf_24 PF13578.6 EGD97985.1 - 0.12 13.5 0.0 0.21 12.7 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Dscam_C PF12355.8 EGD97985.1 - 0.2 12.6 3.7 0.42 11.6 3.7 1.5 1 0 0 1 1 1 0 Down syndrome cell adhesion molecule C terminal Prp18 PF02840.15 EGD97985.1 - 0.26 11.3 0.2 0.48 10.5 0.2 1.4 1 0 0 1 1 1 0 Prp18 domain CAP_N PF01213.19 EGD97985.1 - 0.87 9.0 3.0 1.3 8.4 3.0 1.2 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal E1-E2_ATPase PF00122.20 EGD97988.1 - 3.4e-37 127.7 13.8 5.5e-30 104.2 0.4 3.4 4 0 0 4 4 4 2 E1-E2 ATPase Cation_ATPase_C PF00689.21 EGD97988.1 - 3.5e-28 98.5 3.9 3.5e-28 98.5 3.9 2.4 2 1 0 2 2 2 1 Cation transporting ATPase, C-terminus Cation_ATPase PF13246.6 EGD97988.1 - 3.4e-24 84.7 0.0 9.1e-24 83.4 0.0 1.8 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 EGD97988.1 - 2.7e-18 67.0 1.1 4.8e-17 62.9 1.1 2.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EGD97988.1 - 3.1e-14 52.4 0.1 7.8e-14 51.1 0.1 1.7 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 EGD97988.1 - 3.3e-05 23.7 0.7 0.0021 17.8 0.7 2.2 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase BRAP2 PF07576.12 EGD97989.1 - 7.4e-34 115.9 0.0 1.4e-33 115.0 0.0 1.4 1 0 0 1 1 1 1 BRCA1-associated protein 2 zf-UBP PF02148.19 EGD97989.1 - 1.3e-19 70.3 5.2 1.6e-19 70.0 3.7 1.9 2 0 0 2 2 1 1 Zn-finger in ubiquitin-hydrolases and other protein zf-RING_2 PF13639.6 EGD97989.1 - 1.5e-08 34.8 9.2 1.5e-08 34.8 9.2 2.4 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 EGD97989.1 - 2.3e-06 27.3 8.7 2.3e-06 27.3 8.7 2.0 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EGD97989.1 - 0.00053 19.7 5.2 0.00053 19.7 5.2 2.6 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4 PF00097.25 EGD97989.1 - 0.00059 19.6 7.7 0.00059 19.6 7.7 1.9 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EGD97989.1 - 0.00076 19.3 5.4 0.00076 19.3 5.4 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EGD97989.1 - 0.00076 19.4 7.2 0.00076 19.4 7.2 2.3 2 0 0 2 2 2 1 zinc-RING finger domain zf-rbx1 PF12678.7 EGD97989.1 - 0.00081 19.6 6.4 0.00081 19.6 6.4 2.0 2 0 0 2 2 1 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 EGD97989.1 - 0.0015 18.5 5.7 0.0015 18.5 5.7 2.5 2 1 1 3 3 2 1 RING-type zinc-finger Lectin_N PF03954.14 EGD97989.1 - 0.0028 17.4 2.3 0.0041 16.9 1.3 1.7 1 1 0 1 1 1 1 Hepatic lectin, N-terminal domain JAKMIP_CC3 PF16034.5 EGD97989.1 - 0.0028 17.6 7.7 0.0028 17.6 7.7 1.6 2 0 0 2 2 1 1 JAKMIP CC3 domain zf-ANAPC11 PF12861.7 EGD97989.1 - 0.0093 16.0 5.3 0.023 14.7 5.3 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.6 EGD97989.1 - 0.017 15.0 5.0 0.017 15.0 5.0 3.3 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 MIP-T3_C PF17749.1 EGD97989.1 - 0.043 13.8 7.2 0.094 12.7 7.2 1.5 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 C-terminal region zf-RING_6 PF14835.6 EGD97989.1 - 0.068 13.1 7.9 0.023 14.6 4.7 1.9 1 1 0 1 1 1 0 zf-RING of BARD1-type protein ATG16 PF08614.11 EGD97989.1 - 0.15 12.3 20.4 0.026 14.8 13.2 2.1 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) ERM PF00769.19 EGD97989.1 - 0.18 11.6 20.1 0.014 15.2 15.0 1.7 2 0 0 2 2 2 0 Ezrin/radixin/moesin family HALZ PF02183.18 EGD97989.1 - 0.19 12.0 1.4 3.9 7.8 0.1 2.5 2 0 0 2 2 2 0 Homeobox associated leucine zipper GIT_CC PF16559.5 EGD97989.1 - 0.29 11.0 4.9 0.97 9.3 0.7 2.5 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor KASH_CCD PF14662.6 EGD97989.1 - 0.31 10.9 10.5 0.58 9.9 10.5 1.4 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH TerY_C PF15616.6 EGD97989.1 - 0.39 10.8 10.6 1.5 8.9 1.5 2.5 1 1 1 2 2 2 0 TerY-C metal binding domain ZapB PF06005.12 EGD97989.1 - 0.42 11.1 8.3 0.12 12.8 0.4 2.5 1 1 1 2 2 2 0 Cell division protein ZapB TLE_N PF03920.15 EGD97989.1 - 0.74 9.9 5.3 1.4 9.0 2.6 2.4 1 1 1 2 2 2 0 Groucho/TLE N-terminal Q-rich domain TolA_bind_tri PF16331.5 EGD97989.1 - 1 9.5 8.0 2.3 8.4 0.9 2.4 1 1 1 2 2 2 0 TolA binding protein trimerisation zf-RING_4 PF14570.6 EGD97989.1 - 1.6 8.6 6.2 5 7.0 6.2 1.8 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain PRKG1_interact PF15898.5 EGD97989.1 - 1.8 9.5 12.7 1.9 9.4 10.8 2.0 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain UPF0242 PF06785.11 EGD97989.1 - 2.7 8.1 10.2 3.7 7.6 9.2 1.7 2 0 0 2 2 1 0 Uncharacterised protein family (UPF0242) N-terminus Exonuc_VII_L PF02601.15 EGD97989.1 - 3.3 7.2 8.5 6.5 6.2 8.5 1.4 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF1993 PF09351.10 EGD97989.1 - 3.5 7.8 10.5 2.5 8.2 3.5 3.3 3 1 1 4 4 4 0 Domain of unknown function (DUF1993) SHE3 PF17078.5 EGD97989.1 - 3.7 7.2 10.4 22 4.7 10.2 2.2 1 1 0 1 1 1 0 SWI5-dependent HO expression protein 3 TPR_MLP1_2 PF07926.12 EGD97989.1 - 5.7 7.0 23.0 1.6 8.8 19.9 1.6 2 0 0 2 2 1 0 TPR/MLP1/MLP2-like protein AATF-Che1 PF13339.6 EGD97989.1 - 7 7.3 13.3 18 6.0 0.1 2.6 2 1 0 2 2 2 0 Apoptosis antagonizing transcription factor DUF3450 PF11932.8 EGD97989.1 - 7.8 5.7 15.3 15 4.8 13.2 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF3450) DUF1664 PF07889.12 EGD97989.1 - 8 6.5 6.4 19 5.3 0.7 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) APH PF01636.23 EGD97990.1 - 2e-16 60.7 0.0 5.3e-16 59.3 0.0 1.6 1 1 0 1 1 1 1 Phosphotransferase enzyme family Pkinase PF00069.25 EGD97990.1 - 0.0014 18.1 0.0 0.009 15.4 0.0 2.0 2 0 0 2 2 2 1 Protein kinase domain Choline_kinase PF01633.20 EGD97990.1 - 0.0038 16.8 0.2 0.01 15.5 0.2 1.8 1 1 0 1 1 1 1 Choline/ethanolamine kinase DASH_Duo1 PF08651.10 EGD97991.1 - 0.0022 17.7 1.7 0.005 16.6 0.4 1.8 1 1 1 2 2 2 1 DASH complex subunit Duo1 TMF_TATA_bd PF12325.8 EGD97991.1 - 0.23 11.7 7.3 0.66 10.2 7.3 1.7 1 1 0 1 1 1 0 TATA element modulatory factor 1 TATA binding ubiquitin PF00240.23 EGD97992.1 - 1.4e-101 332.3 14.2 2.3e-33 113.7 0.7 3.0 3 0 0 3 3 3 3 Ubiquitin family Rad60-SLD PF11976.8 EGD97992.1 - 7.7e-48 160.2 14.9 1.8e-15 56.5 0.8 3.0 3 0 0 3 3 3 3 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EGD97992.1 - 1.2e-17 64.1 6.8 0.00026 21.4 0.2 4.6 3 3 0 3 3 3 3 Ubiquitin-like domain TBK1_ULD PF18396.1 EGD97992.1 - 4.1e-12 45.9 2.5 0.018 15.0 0.1 3.2 3 0 0 3 3 3 3 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_5 PF18037.1 EGD97992.1 - 1.1e-11 45.0 2.8 0.023 15.1 0.1 3.1 1 1 2 3 3 3 3 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 EGD97992.1 - 6.2e-11 42.4 1.6 0.078 13.1 0.0 3.9 3 3 0 3 3 3 3 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 EGD97992.1 - 4.1e-10 40.2 0.5 0.17 12.5 0.0 3.2 1 1 2 3 3 3 3 DUF2407 ubiquitin-like domain Sde2_N_Ubi PF13019.6 EGD97992.1 - 1.8e-07 31.2 0.3 0.71 9.7 0.0 3.1 1 1 2 3 3 3 3 Silencing defective 2 N-terminal ubiquitin domain Ubiquitin_4 PF18036.1 EGD97992.1 - 4.1e-06 26.8 16.7 11 6.1 0.2 6.0 6 0 0 6 6 6 0 Ubiquitin-like domain DUF3861 PF12977.7 EGD97992.1 - 5.9e-05 23.2 1.2 6.9 6.9 0.0 3.2 3 0 0 3 3 3 0 Domain of Unknown Function with PDB structure (DUF3861) DUF2870 PF11069.8 EGD97992.1 - 0.00024 21.4 0.0 20 5.6 0.0 3.7 3 0 0 3 3 3 0 Protein of unknown function (DUF2870) Methyltrans_RNA PF04452.14 EGD97992.1 - 0.00033 20.1 0.2 0.83 8.9 0.0 2.4 2 0 0 2 2 2 2 RNA methyltransferase Big_7 PF17957.1 EGD97992.1 - 0.00036 21.2 0.1 22 5.9 0.0 3.2 3 0 0 3 3 3 0 Bacterial Ig domain ACT_5 PF13710.6 EGD97992.1 - 0.0012 18.6 2.3 13 5.7 0.0 3.3 3 0 0 3 3 3 0 ACT domain Big_3_3 PF13750.6 EGD97992.1 - 0.0019 17.8 0.0 21 4.8 0.0 3.2 3 0 0 3 3 3 0 Bacterial Ig-like domain (group 3) NEAT PF05031.12 EGD97992.1 - 0.0037 17.9 1.7 0.27 11.9 1.8 2.4 1 1 0 1 1 1 1 Iron Transport-associated domain DUF969 PF06149.12 EGD97992.1 - 0.0046 16.4 0.0 12 5.2 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF969) UDP-g_GGTase PF06427.11 EGD97992.1 - 0.0088 16.2 3.5 4.1 7.6 0.1 3.2 4 0 0 4 4 3 2 UDP-glucose:Glycoprotein Glucosyltransferase YcgR_2 PF12945.7 EGD97992.1 - 0.014 15.6 3.0 31 4.8 0.1 3.3 3 0 0 3 3 3 0 Flagellar protein YcgR ACT_4 PF13291.6 EGD97992.1 - 0.019 15.6 0.3 79 3.9 0.0 3.3 3 0 0 3 3 3 0 ACT domain DUF493 PF04359.14 EGD97992.1 - 0.023 15.3 0.0 86 3.8 0.0 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF493) Raf1_HTH PF18579.1 EGD97992.1 - 0.032 13.9 0.1 72 3.2 0.0 3.2 3 0 0 3 3 3 0 Rubisco accumulation factor 1 helix turn helix domain ORF11CD3 PF10549.9 EGD97992.1 - 0.061 13.5 0.0 62 3.8 0.0 3.7 3 0 0 3 3 3 0 ORF11CD3 domain Tash_PEST PF07708.11 EGD97992.1 - 0.13 12.4 18.4 4.5 7.6 1.4 3.3 3 0 0 3 3 3 0 Tash protein PEST motif ProRS-C_2 PF09181.10 EGD97992.1 - 0.15 12.2 2.6 78 3.5 0.1 3.1 3 0 0 3 3 3 0 Prolyl-tRNA synthetase, C-terminal Myosin_N PF02736.19 EGD97992.1 - 0.23 11.3 3.4 76 3.3 0.0 4.4 3 0 0 3 3 3 0 Myosin N-terminal SH3-like domain DMA PF03474.14 EGD97992.1 - 0.27 10.9 1.5 72 3.1 0.0 3.2 3 0 0 3 3 3 0 DMRTA motif FlgD_ig PF13860.6 EGD97992.1 - 0.46 10.4 5.1 62 3.6 0.1 3.4 3 0 0 3 3 3 0 FlgD Ig-like domain Phage_sheath_1N PF17481.2 EGD97992.1 - 0.56 10.7 5.3 2.5e+02 2.2 5.3 3.1 1 1 0 1 1 1 0 Phage tail sheath protein beta-sandwich domain Plexin_cytopl PF08337.12 EGD97992.1 - 2.3 6.8 11.7 13 4.3 0.5 3.9 2 1 0 3 3 3 0 Plexin cytoplasmic RasGAP domain PI3K_p85B PF02192.16 EGD97992.1 - 5.1 6.9 6.0 98 2.8 0.1 3.2 3 0 0 3 3 3 0 PI3-kinase family, p85-binding domain Zn_clus PF00172.18 EGD97993.1 - 0.0045 17.1 7.8 0.01 16.0 7.8 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Prenyltrans PF00432.21 EGD97994.1 - 1.6e-31 107.7 36.8 1.4e-12 47.1 1.1 6.4 6 0 0 6 6 6 5 Prenyltransferase and squalene oxidase repeat SR-25 PF10500.9 EGD97994.1 - 0.061 12.9 7.5 0.093 12.3 7.5 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein eIF3_subunit PF08597.10 EGD97994.1 - 0.29 11.0 7.6 0.4 10.6 7.6 1.1 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit Peptidase_S49_N PF08496.10 EGD97994.1 - 2 8.4 5.8 3.2 7.8 5.8 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal DUF3464 PF11947.8 EGD97994.1 - 4.4 7.0 5.5 7.6 6.3 5.5 1.3 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 dsrm PF00035.26 EGD97995.1 - 9.1e-05 23.1 0.0 0.00015 22.4 0.0 1.3 1 0 0 1 1 1 1 Double-stranded RNA binding motif DND1_DSRM PF14709.7 EGD97995.1 - 0.025 14.8 0.0 0.049 13.9 0.0 1.4 1 0 0 1 1 1 0 double strand RNA binding domain from DEAD END PROTEIN 1 DUF4692 PF15763.5 EGD97995.1 - 0.33 11.4 1.1 0.7 10.3 1.1 1.5 1 0 0 1 1 1 0 Regulator of human erythroid cell expansion (RHEX) DUF4448 PF14610.6 EGD98000.1 - 6.7e-37 127.1 0.0 9.9e-37 126.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) LapA_dom PF06305.11 EGD98000.1 - 0.0017 18.1 0.6 0.0041 16.9 0.6 1.6 1 0 0 1 1 1 1 Lipopolysaccharide assembly protein A domain Alpha_GJ PF03229.13 EGD98000.1 - 1.7 9.2 15.4 5.4 7.6 11.8 2.2 2 0 0 2 2 2 0 Alphavirus glycoprotein J Mito_fiss_reg PF05308.11 EGD98000.1 - 3.6 7.6 5.6 45 4.0 0.0 2.2 2 0 0 2 2 2 0 Mitochondrial fission regulator Hpt PF01627.23 EGD98001.1 - 2.6e-14 53.3 0.0 4.1e-14 52.6 0.0 1.3 1 0 0 1 1 1 1 Hpt domain Ribonuc_L-PSP PF01042.21 EGD98001.1 - 0.13 12.2 0.0 0.44 10.6 0.0 1.8 1 1 1 2 2 2 0 Endoribonuclease L-PSP APH PF01636.23 EGD98003.1 - 9.2e-17 61.8 0.0 1.2e-16 61.4 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EGD98003.1 - 0.00019 21.1 0.0 0.00027 20.6 0.0 1.2 1 0 0 1 1 1 1 Choline/ethanolamine kinase DUF1679 PF07914.11 EGD98003.1 - 0.0073 15.2 0.0 0.011 14.6 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1679) Pkinase PF00069.25 EGD98003.1 - 0.14 11.5 0.0 1 8.7 0.0 1.9 2 0 0 2 2 2 0 Protein kinase domain HMGL-like PF00682.19 EGD98004.1 - 4.3e-79 265.8 0.3 6.1e-79 265.3 0.3 1.2 1 0 0 1 1 1 1 HMGL-like PTH2 PF01981.16 EGD98006.1 - 2.8e-42 143.7 0.0 3.5e-42 143.4 0.0 1.1 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 Ribosomal_60s PF00428.19 EGD98006.1 - 0.0027 18.3 1.1 0.0044 17.6 1.1 1.4 1 0 0 1 1 1 1 60s Acidic ribosomal protein FAM176 PF14851.6 EGD98006.1 - 0.0068 16.1 0.1 0.011 15.4 0.1 1.4 1 0 0 1 1 1 1 FAM176 family SDA1 PF05285.12 EGD98006.1 - 0.02 14.3 1.0 0.021 14.3 1.0 1.1 1 0 0 1 1 1 0 SDA1 GOLD_2 PF13897.6 EGD98006.1 - 0.1 13.1 0.3 0.14 12.6 0.3 1.2 1 0 0 1 1 1 0 Golgi-dynamics membrane-trafficking Sec23_trunk PF04811.15 EGD98006.1 - 0.13 11.8 0.0 0.19 11.2 0.0 1.2 1 0 0 1 1 1 0 Sec23/Sec24 trunk domain CENP-B_dimeris PF09026.10 EGD98006.1 - 0.13 12.6 11.5 0.22 11.9 11.5 1.3 1 0 0 1 1 1 0 Centromere protein B dimerisation domain NOA36 PF06524.12 EGD98006.1 - 0.16 11.3 8.0 0.23 10.7 8.0 1.2 1 0 0 1 1 1 0 NOA36 protein DUF3245 PF11595.8 EGD98006.1 - 0.31 11.5 2.8 1.4 9.4 1.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3245) DNA_pol_phi PF04931.13 EGD98006.1 - 0.32 9.1 7.8 0.38 8.8 7.8 1.1 1 0 0 1 1 1 0 DNA polymerase phi Astro_capsid_p PF12226.8 EGD98006.1 - 0.48 9.5 3.5 0.6 9.2 3.5 1.1 1 0 0 1 1 1 0 Turkey astrovirus capsid protein Nop14 PF04147.12 EGD98006.1 - 0.99 7.5 5.8 1.2 7.3 5.8 1.0 1 0 0 1 1 1 0 Nop14-like family PBP1_TM PF14812.6 EGD98006.1 - 2 8.8 7.3 3.8 7.9 7.3 1.4 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF2457 PF10446.9 EGD98006.1 - 8.9 5.3 12.1 12 4.9 12.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) SART-1 PF03343.13 EGD98007.1 - 2.1e-156 522.2 54.8 2.5e-156 521.9 54.8 1.0 1 0 0 1 1 1 1 SART-1 family FeoC PF09012.10 EGD98007.1 - 0.0055 16.7 1.4 2.9 8.0 0.1 2.9 3 0 0 3 3 3 2 FeoC like transcriptional regulator WD40 PF00400.32 EGD98008.1 - 1.5e-16 60.4 7.9 0.00031 21.5 0.0 5.5 6 1 0 6 6 6 3 WD domain, G-beta repeat Nucleoporin_N PF08801.11 EGD98008.1 - 0.00073 18.4 0.0 0.53 9.0 0.0 2.2 1 1 0 2 2 2 2 Nup133 N terminal like ANAPC4_WD40 PF12894.7 EGD98008.1 - 0.0029 17.9 0.0 3.5 8.0 0.0 3.4 3 1 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain PQQ_3 PF13570.6 EGD98008.1 - 0.068 13.7 0.1 22 5.7 0.0 3.1 3 0 0 3 3 3 0 PQQ-like domain ELL PF10390.9 EGD98009.1 - 0.00015 21.4 0.0 0.00015 21.4 0.0 2.5 2 1 0 2 2 2 1 RNA polymerase II elongation factor ELL APH PF01636.23 EGD98010.1 - 7.5e-11 42.4 2.6 7.9e-09 35.8 0.3 2.7 3 0 0 3 3 3 2 Phosphotransferase enzyme family DUF155 PF02582.14 EGD98011.1 - 5.1e-53 179.8 0.0 1.1e-52 178.7 0.0 1.6 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 Aldedh PF00171.22 EGD98012.1 - 1.8e-143 478.4 0.2 2.1e-143 478.2 0.2 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.11 EGD98012.1 - 0.15 11.5 0.1 0.33 10.4 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1487) Pkinase PF00069.25 EGD98014.1 - 4.7e-22 78.6 0.0 6.4e-22 78.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD98014.1 - 1.6e-11 44.0 0.0 1.9e-11 43.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase TetR_C_15 PF17918.1 EGD98015.1 - 0.089 13.5 1.6 6.5 7.6 2.1 2.3 1 1 1 2 2 2 0 Tetracyclin repressor-like, C-terminal domain LapA_dom PF06305.11 EGD98015.1 - 0.094 12.5 0.4 0.2 11.5 0.4 1.6 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain YL1 PF05764.13 EGD98017.1 - 9.5e-64 215.8 31.5 9.5e-64 215.8 31.5 2.4 2 1 0 2 2 2 1 YL1 nuclear protein YL1_C PF08265.11 EGD98017.1 - 9.8e-14 50.8 0.4 1.6e-13 50.1 0.4 1.4 1 0 0 1 1 1 1 YL1 nuclear protein C-terminal domain Ecl1 PF12855.7 EGD98018.1 - 2.9e-17 64.4 11.9 3.7e-17 64.0 11.9 1.2 1 0 0 1 1 1 1 ECL1/2/3 zinc binding proteins zf-MYND PF01753.18 EGD98018.1 - 0.53 10.4 7.2 0.9 9.7 7.2 1.3 1 0 0 1 1 1 0 MYND finger DUF2256 PF10013.9 EGD98018.1 - 1.1 9.4 7.3 0.35 11.0 0.9 2.2 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2256) zf_PR_Knuckle PF18445.1 EGD98018.1 - 3.5 7.5 6.4 15 5.5 2.0 2.5 2 0 0 2 2 2 0 PR zinc knuckle motif tRNA-synt_2 PF00152.20 EGD98019.1 - 1.2e-90 303.8 0.0 1.6e-90 303.4 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 EGD98019.1 - 7.3e-09 35.5 0.0 1.4e-08 34.6 0.0 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain PUF PF00806.19 EGD98021.1 - 9.7e-29 97.4 0.0 1.5e-05 24.4 0.0 6.1 6 0 0 6 6 6 5 Pumilio-family RNA binding repeat RRM_1 PF00076.22 EGD98021.1 - 2.3e-11 43.3 0.0 5.3e-11 42.2 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MT-A70 PF05063.14 EGD98022.1 - 4.5e-25 88.5 0.1 6.5e-25 88.0 0.1 1.2 1 0 0 1 1 1 1 MT-A70 Spore_YunB PF09560.10 EGD98022.1 - 0.037 14.0 0.0 0.071 13.1 0.0 1.4 1 0 0 1 1 1 0 Sporulation protein YunB (Spo_YunB) Peptidase_C12 PF01088.21 EGD98023.1 - 2.2e-53 181.1 0.0 2.7e-53 180.8 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 ketoacyl-synt PF00109.26 EGD98024.1 - 8.9e-78 261.4 0.0 8.9e-78 261.4 0.0 2.6 3 0 0 3 3 2 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.21 EGD98024.1 - 3e-75 253.7 0.5 5.1e-75 252.9 0.5 1.4 1 0 0 1 1 1 1 Acyl transferase domain KR PF08659.10 EGD98024.1 - 2.6e-57 193.6 0.1 7e-57 192.2 0.1 1.8 1 0 0 1 1 1 1 KR domain PS-DH PF14765.6 EGD98024.1 - 5.3e-44 150.6 1.3 1.1e-43 149.6 1.3 1.5 1 0 0 1 1 1 1 Polyketide synthase dehydratase Ketoacyl-synt_C PF02801.22 EGD98024.1 - 1.4e-34 118.6 0.1 6.2e-34 116.5 0.0 2.2 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain Thioesterase PF00975.20 EGD98024.1 - 2.6e-21 76.8 0.0 6.1e-21 75.6 0.0 1.7 1 0 0 1 1 1 1 Thioesterase domain ADH_zinc_N PF00107.26 EGD98024.1 - 1.4e-20 73.6 0.9 1.6e-19 70.2 0.6 2.5 2 0 0 2 2 2 1 Zinc-binding dehydrogenase adh_short PF00106.25 EGD98024.1 - 1.4e-16 60.5 0.6 7.2e-14 51.7 0.0 2.6 2 0 0 2 2 2 2 short chain dehydrogenase KAsynt_C_assoc PF16197.5 EGD98024.1 - 1.6e-13 51.1 0.0 1.8e-11 44.4 0.0 2.7 2 0 0 2 2 2 1 Ketoacyl-synthetase C-terminal extension ADH_zinc_N_2 PF13602.6 EGD98024.1 - 3.4e-13 50.8 0.0 2.4e-12 48.1 0.0 2.6 2 0 0 2 2 1 1 Zinc-binding dehydrogenase Abhydrolase_6 PF12697.7 EGD98024.1 - 5.6e-06 27.1 1.1 2.4e-05 25.1 0.4 2.5 2 0 0 2 2 2 1 Alpha/beta hydrolase family ADH_N PF08240.12 EGD98024.1 - 1.4e-05 24.9 0.3 4e-05 23.5 0.3 1.8 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain PP-binding PF00550.25 EGD98024.1 - 1.5e-05 25.3 0.0 3.6e-05 24.0 0.0 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site Epimerase PF01370.21 EGD98024.1 - 3.9e-05 23.2 0.4 0.0001 21.9 0.0 1.8 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family Thiolase_N PF00108.23 EGD98024.1 - 0.00016 21.1 0.5 0.00047 19.6 0.5 1.7 1 0 0 1 1 1 1 Thiolase, N-terminal domain Polysacc_synt_2 PF02719.15 EGD98024.1 - 0.00089 18.5 0.0 0.0015 17.7 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein GDP_Man_Dehyd PF16363.5 EGD98024.1 - 0.0048 16.4 0.0 0.0075 15.7 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase SAT PF16073.5 EGD98024.1 - 0.0099 15.6 1.1 0.88 9.2 0.6 2.8 2 1 0 2 2 2 1 Starter unit:ACP transacylase in aflatoxin biosynthesis AlaDh_PNT_C PF01262.21 EGD98024.1 - 0.01 15.2 2.2 0.019 14.2 2.2 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox PF00070.27 EGD98024.1 - 0.054 14.1 0.6 0.87 10.2 0.0 2.8 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Phage_CII PF05269.11 EGD98024.1 - 0.2 11.9 0.0 0.72 10.1 0.0 1.9 2 0 0 2 2 1 0 Bacteriophage CII protein YjeF_N PF03853.15 EGD98024.1 - 0.54 10.1 2.5 4.9 7.0 0.0 2.4 2 0 0 2 2 2 0 YjeF-related protein N-terminus FAD_binding_3 PF01494.19 EGD98024.1 - 1.8 7.7 5.1 0.14 11.4 0.1 1.6 2 0 0 2 2 1 0 FAD binding domain DcpS PF05652.12 EGD98025.1 - 6.2e-34 117.0 0.0 1.1e-33 116.1 0.0 1.4 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme (DcpS) N-terminal DcpS_C PF11969.8 EGD98025.1 - 2e-31 108.8 0.4 3e-31 108.3 0.4 1.3 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding Alk_phosphatase PF00245.20 EGD98026.1 - 1.3e-57 195.6 1.5 4.7e-56 190.5 1.5 2.8 1 1 0 1 1 1 1 Alkaline phosphatase Sulfatase PF00884.23 EGD98026.1 - 5.5e-08 32.6 1.3 1.5e-07 31.2 0.3 2.0 1 1 1 2 2 2 1 Sulfatase Phosphodiest PF01663.22 EGD98026.1 - 0.00093 18.9 0.1 0.0016 18.1 0.1 1.4 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase DUF229 PF02995.17 EGD98026.1 - 0.0011 17.7 0.1 0.0024 16.6 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF229) GPAT_N PF14829.6 EGD98026.1 - 0.023 14.7 0.0 0.054 13.5 0.0 1.5 1 0 0 1 1 1 0 Glycerol-3-phosphate acyltransferase N-terminal RNase_H2_suC PF08615.11 EGD98027.1 - 2.9e-27 95.5 0.2 4.7e-27 94.9 0.0 1.4 2 0 0 2 2 2 1 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) Peptidase_S24 PF00717.23 EGD98027.1 - 0.045 13.7 0.0 0.1 12.6 0.0 1.6 1 0 0 1 1 1 0 Peptidase S24-like RNase_T PF00929.24 EGD98028.1 - 4.9e-20 72.7 0.0 1.6e-19 71.0 0.0 1.9 1 1 0 1 1 1 1 Exonuclease Nop53 PF07767.11 EGD98029.1 - 7.7e-101 338.4 39.1 1.2e-100 337.8 39.1 1.3 1 0 0 1 1 1 1 Nop53 (60S ribosomal biogenesis) GTA_holin_3TM PF11351.8 EGD98029.1 - 1.1 9.8 6.6 0.68 10.5 3.1 2.3 2 0 0 2 2 2 0 Holin of 3TMs, for gene-transfer release Myb_Cef PF11831.8 EGD98030.1 - 7.1e-51 173.1 6.4 7.1e-51 173.1 6.4 2.9 3 0 0 3 3 3 1 pre-mRNA splicing factor component Myb_DNA-binding PF00249.31 EGD98030.1 - 1.2e-21 76.7 5.8 2.1e-10 40.6 0.7 3.2 3 0 0 3 3 3 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EGD98030.1 - 1.5e-19 70.0 4.7 1.5e-12 47.6 1.4 2.8 1 1 1 2 2 2 2 Myb-like DNA-binding domain Rap1_C PF11626.8 EGD98030.1 - 0.058 13.5 0.1 1 9.5 0.0 2.7 2 0 0 2 2 2 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain MOZ_SAS PF01853.18 EGD98031.1 - 8.3e-79 263.4 0.0 1.3e-78 262.8 0.0 1.3 1 0 0 1 1 1 1 MOZ/SAS family Tudor-knot PF11717.8 EGD98031.1 - 5.7e-23 80.6 0.0 1.1e-22 79.7 0.0 1.5 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain zf-MYST PF17772.1 EGD98031.1 - 3.6e-22 77.7 0.3 7.2e-22 76.8 0.3 1.5 1 0 0 1 1 1 1 MYST family zinc finger domain Acetyltransf_7 PF13508.7 EGD98031.1 - 0.005 17.2 0.0 0.011 16.1 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EGD98031.1 - 0.046 14.0 0.0 0.12 12.6 0.0 1.7 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family DUF1918 PF08940.11 EGD98031.1 - 0.093 12.4 0.0 0.35 10.5 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1918) Orthopox_C10L PF07020.11 EGD98032.1 - 0.21 12.4 8.5 2.6 8.9 0.2 3.5 3 0 0 3 3 3 0 Orthopoxvirus C10L protein F1F0-ATPsyn_F PF10791.9 EGD98033.1 - 1.3e-38 131.3 0.1 1.5e-38 131.1 0.1 1.0 1 0 0 1 1 1 1 Mitochondrial F1-F0 ATP synthase subunit F of fungi WRW PF10206.9 EGD98033.1 - 0.0096 16.3 0.0 0.011 16.1 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial F1F0-ATP synthase, subunit f ETC_C1_NDUFA4 PF04800.12 EGD98034.1 - 2.2e-36 124.0 2.0 3.2e-36 123.5 2.0 1.2 1 0 0 1 1 1 1 ETC complex I subunit conserved region Nipped-B_C PF12830.7 EGD98035.1 - 4.1e-48 163.9 5.6 4.7e-46 157.1 1.1 3.8 3 1 0 3 3 3 2 Sister chromatid cohesion C-terminus Cohesin_HEAT PF12765.7 EGD98035.1 - 1.2e-10 41.4 2.5 1.2e-10 41.4 2.5 3.0 3 0 0 3 3 3 1 HEAT repeat associated with sister chromatid cohesion Cnd3 PF12719.7 EGD98035.1 - 6.5e-05 22.3 0.7 0.29 10.3 0.2 2.9 2 0 0 2 2 2 2 Nuclear condensing complex subunits, C-term domain Cnd1 PF12717.7 EGD98035.1 - 0.0003 20.9 5.0 0.18 11.8 0.0 3.3 2 1 1 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 EGD98035.1 - 0.0003 20.8 2.3 0.49 10.8 0.1 5.0 4 0 0 4 4 4 1 HEAT repeat Adaptin_N PF01602.20 EGD98035.1 - 0.071 11.7 8.3 0.14 10.7 2.3 3.4 2 1 1 3 3 3 0 Adaptin N terminal region Vac14_Fab1_bd PF12755.7 EGD98035.1 - 0.1 13.2 0.4 1.8 9.2 0.1 2.9 2 0 0 2 2 2 0 Vacuolar 14 Fab1-binding region Methyltransf_11 PF08241.12 EGD98036.1 - 2.1e-08 34.7 0.0 4e-08 33.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EGD98036.1 - 3.5e-06 27.6 0.0 9.9e-06 26.2 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.18 EGD98036.1 - 0.00015 21.1 0.0 0.00024 20.5 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family TFIIS_C PF01096.18 EGD98037.1 - 4.7e-15 55.1 2.1 4.7e-15 55.1 2.1 2.9 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) RNA_POL_M_15KD PF02150.16 EGD98037.1 - 2.5e-06 27.3 0.5 2.5e-06 27.3 0.5 2.6 3 0 0 3 3 3 1 RNA polymerases M/15 Kd subunit RecR PF02132.15 EGD98037.1 - 0.0024 17.4 0.9 0.0024 17.4 0.9 2.0 2 0 0 2 2 2 1 RecR protein Ribosomal_S27e PF01667.17 EGD98037.1 - 0.012 15.2 3.9 2.6 7.8 0.0 3.3 2 1 1 3 3 3 0 Ribosomal protein S27 zinc_ribbon_2 PF13240.6 EGD98037.1 - 0.015 15.0 8.7 7.4 6.4 0.2 3.9 4 0 0 4 4 4 0 zinc-ribbon domain zf-ribbon_3 PF13248.6 EGD98037.1 - 0.018 14.4 8.4 4.5 6.8 0.0 3.8 4 0 0 4 4 4 0 zinc-ribbon domain Prok-RING_1 PF14446.6 EGD98037.1 - 0.031 14.2 3.4 4.9 7.2 0.7 2.5 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 DZR PF12773.7 EGD98037.1 - 0.032 14.3 7.3 0.11 12.5 0.4 2.5 1 1 1 2 2 2 0 Double zinc ribbon UCH_1 PF13423.6 EGD98037.1 - 0.033 13.8 0.5 0.04 13.5 0.5 1.1 1 0 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase tRNA-synt_1f PF01921.18 EGD98037.1 - 0.038 12.9 0.2 0.063 12.2 0.2 1.3 1 0 0 1 1 1 0 tRNA synthetases class I (K) NMD3 PF04981.13 EGD98037.1 - 0.041 13.4 3.8 0.13 11.7 0.2 2.1 1 1 1 2 2 2 0 NMD3 family zf-RING_7 PF02591.15 EGD98037.1 - 0.1 12.8 8.7 1.1 9.5 0.1 3.5 3 1 1 4 4 4 0 C4-type zinc ribbon domain zinc_ribbon_9 PF14369.6 EGD98037.1 - 0.11 12.7 3.0 1.8 8.9 0.1 2.6 2 1 0 2 2 2 0 zinc-ribbon DpnI PF06044.12 EGD98037.1 - 0.19 11.4 2.2 0.29 10.7 0.1 2.0 1 1 0 2 2 2 0 Dam-replacing family zf-C4_Topoisom PF01396.19 EGD98037.1 - 0.4 10.5 4.3 1 9.2 0.2 3.1 2 2 1 3 3 3 0 Topoisomerase DNA binding C4 zinc finger CpXC PF14353.6 EGD98037.1 - 0.61 10.1 5.2 2.9 8.0 2.6 2.5 1 1 0 1 1 1 0 CpXC protein Zn-ribbon_8 PF09723.10 EGD98037.1 - 0.85 9.8 0.1 0.85 9.8 0.1 2.9 3 0 0 3 3 3 0 Zinc ribbon domain Nudix_N_2 PF14803.6 EGD98037.1 - 1.2 9.1 9.9 0.64 10.0 0.4 2.8 3 0 0 3 3 3 0 Nudix N-terminal Zn_ribbon_recom PF13408.6 EGD98037.1 - 1.3 9.5 8.1 3.5 8.2 0.4 2.6 2 1 0 2 2 2 0 Recombinase zinc beta ribbon domain Auto_anti-p27 PF06677.12 EGD98037.1 - 1.4 9.2 6.1 4.9 7.4 0.1 3.2 3 0 0 3 3 3 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) zf-C2H2 PF00096.26 EGD98037.1 - 1.6 9.3 5.1 13 6.4 0.1 3.5 3 0 0 3 3 3 0 Zinc finger, C2H2 type OrfB_Zn_ribbon PF07282.11 EGD98037.1 - 4.3 7.3 8.8 10 6.2 0.4 2.7 2 2 0 2 2 2 0 Putative transposase DNA-binding domain TF_Zn_Ribbon PF08271.12 EGD98037.1 - 4.5 6.9 13.5 5.7 6.5 0.4 3.3 2 2 0 3 3 3 0 TFIIB zinc-binding zf-IS66 PF13005.7 EGD98037.1 - 7.9 7.0 12.1 3.8 8.0 0.1 3.6 3 1 1 4 4 3 0 zinc-finger binding domain of transposase IS66 HEAT_2 PF13646.6 EGD98038.1 - 3e-27 94.8 6.8 1.7e-11 44.4 0.1 3.6 2 2 1 3 3 3 3 HEAT repeats HEAT_PBS PF03130.16 EGD98038.1 - 2e-18 65.1 1.8 0.0032 18.0 0.0 6.5 7 0 0 7 7 7 4 PBS lyase HEAT-like repeat HEAT PF02985.22 EGD98038.1 - 2.8e-05 24.0 2.8 9.7 6.8 0.0 5.9 6 0 0 6 6 6 2 HEAT repeat HEAT_EZ PF13513.6 EGD98038.1 - 0.00028 21.3 4.5 0.24 11.9 0.0 5.0 3 2 2 5 5 5 1 HEAT-like repeat Pyr_redox_2 PF07992.14 EGD98039.1 - 8.4e-41 140.1 0.0 1.2e-40 139.6 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EGD98039.1 - 2.4e-10 40.8 0.0 4.8e-09 36.7 0.0 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase EF-hand_1 PF00036.32 EGD98039.1 - 1.2e-05 24.5 0.1 4.6e-05 22.7 0.1 2.1 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 EGD98039.1 - 0.00018 21.1 0.3 0.0006 19.5 0.3 1.9 1 0 0 1 1 1 1 EF-hand domain EF-hand_5 PF13202.6 EGD98039.1 - 0.0003 20.2 0.1 0.00074 18.9 0.1 1.7 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 EGD98039.1 - 0.003 18.0 0.1 0.009 16.4 0.1 1.9 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_4 PF12763.7 EGD98039.1 - 0.27 11.2 1.1 3.4 7.7 0.0 2.9 4 0 0 4 4 4 0 Cytoskeletal-regulatory complex EF hand CLTH PF10607.9 EGD98040.1 - 3.4e-33 114.6 0.3 4.7e-33 114.2 0.3 1.1 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain LisH PF08513.11 EGD98040.1 - 3.1e-09 36.5 0.1 6.9e-09 35.4 0.1 1.6 1 0 0 1 1 1 1 LisH PRK PF00485.18 EGD98041.1 - 7.5e-56 189.0 0.0 9.5e-56 188.7 0.0 1.1 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family AAA_18 PF13238.6 EGD98041.1 - 3.4e-06 27.6 0.0 5.4e-06 27.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 EGD98041.1 - 0.0003 20.1 0.0 0.00048 19.5 0.0 1.3 1 0 0 1 1 1 1 Zeta toxin CPT PF07931.12 EGD98041.1 - 0.0033 17.3 0.0 0.0088 15.9 0.0 1.7 2 0 0 2 2 2 1 Chloramphenicol phosphotransferase-like protein DUF87 PF01935.17 EGD98041.1 - 0.0073 16.4 0.1 0.014 15.5 0.1 1.8 1 1 0 1 1 1 1 Helicase HerA, central domain Cytidylate_kin PF02224.18 EGD98041.1 - 0.011 15.5 0.1 1 9.1 0.0 2.1 2 0 0 2 2 2 0 Cytidylate kinase AAA_17 PF13207.6 EGD98041.1 - 0.032 14.6 0.4 0.7 10.3 0.4 2.3 1 1 0 1 1 1 0 AAA domain CbiA PF01656.23 EGD98041.1 - 0.045 13.8 0.0 0.088 12.9 0.0 1.4 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_33 PF13671.6 EGD98041.1 - 0.083 13.0 0.0 0.21 11.7 0.0 1.7 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.27 EGD98041.1 - 0.17 12.4 0.0 0.28 11.7 0.0 1.3 1 0 0 1 1 1 0 ABC transporter NUC153 PF08159.12 EGD98042.1 - 2.4e-14 52.8 8.3 1.3e-13 50.4 0.2 3.6 3 0 0 3 3 3 2 NUC153 domain ATP-synt_J PF04911.12 EGD98042.1 - 0.053 13.1 0.5 0.42 10.2 0.0 2.3 2 0 0 2 2 2 0 ATP synthase j chain DUF4148 PF13663.6 EGD98042.1 - 0.19 11.9 0.1 0.19 11.9 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4148) Npa1 PF11707.8 EGD98043.1 - 4.3e-93 312.4 1.1 4.3e-93 312.4 1.1 2.2 2 0 0 2 2 2 1 Ribosome 60S biogenesis N-terminal NopRA1 PF16201.5 EGD98043.1 - 5.8e-57 192.5 0.1 6e-56 189.2 0.0 2.7 3 0 0 3 3 3 1 Nucleolar pre-ribosomal-associated protein 1 Mating_N PF12731.7 EGD98043.1 - 0.19 11.8 2.0 0.39 10.8 0.0 2.6 3 0 0 3 3 3 0 Mating-type protein beta 1 HA2 PF04408.23 EGD98045.1 - 1.1e-23 83.5 0.7 4.3e-23 81.7 0.0 2.4 2 0 0 2 2 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 EGD98045.1 - 2.7e-18 66.1 0.0 5.9e-18 65.0 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 EGD98045.1 - 2.2e-13 50.5 0.0 5.9e-13 49.1 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain S1 PF00575.23 EGD98045.1 - 9.7e-10 38.7 1.7 2.8e-09 37.2 1.7 1.8 1 0 0 1 1 1 1 S1 RNA binding domain DEAD PF00270.29 EGD98045.1 - 0.00029 20.7 0.2 0.00078 19.3 0.2 1.6 1 1 0 1 1 1 1 DEAD/DEAH box helicase T2SSE PF00437.20 EGD98045.1 - 0.0013 17.8 0.0 0.0032 16.6 0.0 1.5 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_22 PF13401.6 EGD98045.1 - 0.025 14.9 0.1 0.077 13.3 0.1 1.9 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EGD98045.1 - 0.075 13.4 0.0 0.24 11.8 0.0 1.8 1 0 0 1 1 1 0 AAA ATPase domain AAA_33 PF13671.6 EGD98045.1 - 0.097 12.8 0.0 0.43 10.7 0.0 2.2 2 0 0 2 2 2 0 AAA domain SUV3_C PF12513.8 EGD98046.1 - 2.4e-16 59.4 0.1 4.7e-16 58.4 0.1 1.6 1 0 0 1 1 1 1 Mitochondrial degradasome RNA helicase subunit C terminal Helicase_C PF00271.31 EGD98046.1 - 3.3e-10 40.3 0.0 7.6e-10 39.1 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Suv3_C_1 PF18147.1 EGD98046.1 - 0.0001 22.1 0.0 0.0002 21.2 0.0 1.5 1 0 0 1 1 1 1 Suv3 C-terminal domain 1 DUF4771 PF15995.5 EGD98046.1 - 0.11 12.8 0.0 0.27 11.5 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4771) Sec1 PF00995.23 EGD98047.1 - 1.7e-112 377.6 0.0 2.2e-112 377.2 0.0 1.1 1 0 0 1 1 1 1 Sec1 family G-patch PF01585.23 EGD98048.1 - 1.3e-07 31.3 0.2 3.2e-07 30.1 0.2 1.6 1 0 0 1 1 1 1 G-patch domain adh_short PF00106.25 EGD98049.1 - 2.2e-11 43.6 0.0 6.5e-11 42.1 0.0 1.7 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.10 EGD98049.1 - 5.8e-06 26.3 0.0 1.6e-05 24.9 0.0 1.8 2 0 0 2 2 2 1 KR domain adh_short_C2 PF13561.6 EGD98049.1 - 6.6e-06 25.9 0.0 1.3e-05 24.9 0.0 1.5 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 EGD98049.1 - 0.0052 16.3 0.1 0.0074 15.8 0.1 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EGD98050.1 - 2.9e-48 165.0 0.0 6.7e-48 163.8 0.0 1.6 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 EGD98050.1 - 1.8e-47 161.9 0.0 2.3e-47 161.5 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EGD98050.1 - 4.2e-15 55.5 0.0 6.6e-15 54.9 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 EGD98050.1 - 1.9e-12 47.0 0.0 2.4e-11 43.3 0.0 2.0 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 EGD98050.1 - 1.6e-11 43.9 0.0 2.2e-11 43.4 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain adh_short PF00106.25 EGD98050.1 - 5.3e-11 42.3 0.0 9.4e-11 41.5 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EGD98050.1 - 2.6e-07 30.7 0.0 4.2e-07 30.0 0.0 1.3 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.6 EGD98050.1 - 1.6e-05 24.6 0.0 4.8e-05 23.0 0.0 1.7 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase NAD_binding_4 PF07993.12 EGD98050.1 - 0.00012 21.4 0.0 0.014 14.6 0.0 2.2 1 1 0 1 1 1 1 Male sterility protein NAD_binding_10 PF13460.6 EGD98050.1 - 0.0011 18.9 0.0 0.0018 18.2 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding UDPG_MGDP_dh_N PF03721.14 EGD98050.1 - 0.011 15.3 0.1 0.024 14.2 0.1 1.5 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NmrA PF05368.13 EGD98050.1 - 0.012 15.2 0.0 0.028 14.0 0.0 1.6 2 0 0 2 2 2 0 NmrA-like family 3HCDH_N PF02737.18 EGD98050.1 - 0.029 14.3 0.0 0.044 13.7 0.0 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_10 PF13460.6 EGD98051.1 - 2.4e-26 92.8 0.0 2.8e-26 92.6 0.0 1.0 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 EGD98051.1 - 8.8e-10 38.5 0.0 1.2e-09 38.1 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family Epimerase PF01370.21 EGD98051.1 - 1.6e-06 27.8 0.0 2.6e-06 27.1 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EGD98051.1 - 2.7e-05 23.3 0.0 3.5e-05 22.9 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Sacchrp_dh_NADP PF03435.18 EGD98051.1 - 0.00045 20.5 0.0 0.00079 19.7 0.0 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain FIST_C PF10442.9 EGD98051.1 - 0.13 12.2 0.0 0.23 11.5 0.0 1.3 1 0 0 1 1 1 0 FIST C domain PAT1 PF09770.9 EGD98052.1 - 0 1135.8 7.6 0 1135.6 7.6 1.0 1 0 0 1 1 1 1 Topoisomerase II-associated protein PAT1 Glyco_transf_15 PF01793.16 EGD98053.1 - 1.1e-127 425.8 10.4 1.4e-127 425.5 10.4 1.0 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase SIC PF03482.13 EGD98053.1 - 0.026 14.7 1.2 0.068 13.4 1.2 1.7 1 0 0 1 1 1 0 sic protein repeat Ribosom_S12_S23 PF00164.25 EGD98054.1 - 2e-30 104.7 1.8 2.8e-30 104.3 1.8 1.2 1 0 0 1 1 1 1 Ribosomal protein S12/S23 HTH_Tnp_IS1 PF12759.7 EGD98054.1 - 0.031 13.9 0.1 0.22 11.2 0.0 2.2 2 0 0 2 2 2 0 InsA C-terminal domain UMP1 PF05348.11 EGD98055.1 - 7e-39 132.7 0.1 8.9e-39 132.4 0.1 1.1 1 0 0 1 1 1 1 Proteasome maturation factor UMP1 Rad60-SLD_2 PF13881.6 EGD98056.1 - 1.7e-12 47.4 0.0 4.1e-12 46.2 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 EGD98056.1 - 0.006 17.1 0.1 0.017 15.7 0.0 1.7 2 0 0 2 2 2 1 DUF2407 ubiquitin-like domain ubiquitin PF00240.23 EGD98056.1 - 0.0089 15.8 0.0 0.017 14.9 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin family IML1 PF12257.8 EGD98057.1 - 5.9e-108 360.3 0.0 8.5e-108 359.8 0.0 1.2 1 0 0 1 1 1 1 Vacuolar membrane-associated protein Iml1 DEP PF00610.21 EGD98057.1 - 3.7e-29 100.6 1.0 7.6e-29 99.6 1.0 1.6 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) FNIP_N PF14636.6 EGD98058.1 - 6.2e-32 111.7 0.2 6.2e-32 111.7 0.2 4.7 2 2 2 5 5 5 1 Folliculin-interacting protein N-terminus FNIP_M PF14637.6 EGD98058.1 - 0.047 13.7 0.2 0.16 12.0 0.1 1.8 1 1 1 2 2 2 0 Folliculin-interacting protein middle domain C9orf72-like PF15019.6 EGD98058.1 - 0.09 12.3 0.0 0.17 11.4 0.0 1.4 1 0 0 1 1 1 0 C9orf72-like protein family Helicase_C PF00271.31 EGD98059.1 - 3.1e-08 33.9 0.0 7.4e-08 32.7 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-C3HC4_3 PF13920.6 EGD98059.1 - 0.0007 19.4 10.9 0.0007 19.4 10.9 2.3 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Trypan_PARP PF05887.11 EGD98059.1 - 0.0022 18.0 18.5 0.0045 17.0 18.5 1.5 1 0 0 1 1 1 1 Procyclic acidic repetitive protein (PARP) zf-C3HC4 PF00097.25 EGD98059.1 - 0.39 10.6 12.1 1.5 8.7 12.2 2.1 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) TonB_N PF16031.5 EGD98059.1 - 1.5 9.3 13.5 2.9 8.4 13.5 1.4 1 0 0 1 1 1 0 TonB polyproline region Neisseria_TspB PF05616.13 EGD98059.1 - 2 6.8 3.9 2.6 6.4 3.9 1.1 1 0 0 1 1 1 0 Neisseria meningitidis TspB protein Prok-RING_4 PF14447.6 EGD98059.1 - 6.9 6.6 16.9 0.23 11.3 6.6 2.4 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 TPR_2 PF07719.17 EGD98060.1 - 2.2e-10 39.9 19.4 0.0003 20.7 0.0 6.4 6 0 0 6 6 5 4 Tetratricopeptide repeat TPR_1 PF00515.28 EGD98060.1 - 7e-08 32.0 9.0 0.00031 20.4 0.0 5.4 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_8 PF13181.6 EGD98060.1 - 1.1e-07 31.5 0.4 0.22 11.8 0.0 5.9 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_19 PF14559.6 EGD98060.1 - 3.9e-06 27.3 19.6 0.044 14.3 4.2 5.5 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_16 PF13432.6 EGD98060.1 - 7.7e-05 23.3 22.2 0.00035 21.2 0.2 5.8 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_12 PF13424.6 EGD98060.1 - 0.00039 20.6 15.0 1.2 9.4 3.3 5.6 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_14 PF13428.6 EGD98060.1 - 0.001 19.7 21.5 0.034 14.9 0.3 7.8 8 2 1 9 9 8 1 Tetratricopeptide repeat TPR_7 PF13176.6 EGD98060.1 - 0.0014 18.5 7.0 0.71 10.0 0.0 5.3 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_6 PF13174.6 EGD98060.1 - 0.003 18.1 13.9 6.3 7.7 0.0 6.4 7 0 0 7 7 6 2 Tetratricopeptide repeat TPR_11 PF13414.6 EGD98060.1 - 0.0085 15.8 12.5 0.01 15.5 0.1 5.2 6 0 0 6 6 6 1 TPR repeat TPR_9 PF13371.6 EGD98060.1 - 0.24 11.6 14.4 0.83 9.8 0.1 5.3 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_17 PF13431.6 EGD98060.1 - 0.26 11.8 5.1 28 5.4 0.1 5.1 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_10 PF13374.6 EGD98060.1 - 3.6 7.6 11.4 29 4.7 0.2 5.0 5 0 0 5 5 5 0 Tetratricopeptide repeat Pmp3 PF01679.17 EGD98061.1 - 5.1e-19 68.2 9.5 6.8e-19 67.8 9.5 1.2 1 0 0 1 1 1 1 Proteolipid membrane potential modulator Spt20 PF12090.8 EGD98061.1 - 0.22 11.1 8.5 0.26 10.9 8.5 1.1 1 0 0 1 1 1 0 Spt20 family DUF908 PF06012.12 EGD98061.1 - 0.99 8.7 4.4 1.1 8.5 4.4 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) Totivirus_coat PF05518.11 EGD98061.1 - 2.1 6.3 7.1 2.4 6.1 7.1 1.0 1 0 0 1 1 1 0 Totivirus coat protein SH3_9 PF14604.6 EGD98062.1 - 1.5e-05 24.7 1.7 1.7e-05 24.6 0.2 1.9 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.28 EGD98062.1 - 0.00023 20.7 0.1 0.00042 19.8 0.1 1.4 1 0 0 1 1 1 1 SH3 domain Rax2 PF12768.7 EGD98062.1 - 0.021 14.3 0.0 0.047 13.1 0.0 1.6 2 0 0 2 2 2 0 Cortical protein marker for cell polarity Syndecan PF01034.20 EGD98062.1 - 0.033 14.1 0.0 0.059 13.3 0.0 1.3 1 0 0 1 1 1 0 Syndecan domain SKG6 PF08693.10 EGD98062.1 - 0.36 10.3 1.8 0.69 9.4 1.8 1.4 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Fungal_trans PF04082.18 EGD98066.1 - 7.4e-21 74.4 0.0 1.7e-20 73.2 0.0 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EGD98066.1 - 8.4e-05 22.6 7.8 0.00018 21.5 7.8 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Na_Ca_ex PF01699.24 EGD98067.1 - 6.6e-43 146.3 38.7 3e-23 82.5 15.2 2.3 2 0 0 2 2 2 2 Sodium/calcium exchanger protein GHMP_kinases_N PF00288.26 EGD98068.1 - 1.7e-15 57.0 1.8 4.1e-15 55.8 1.8 1.6 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 EGD98068.1 - 1.1e-07 32.1 0.0 2.3e-07 31.0 0.0 1.6 1 0 0 1 1 1 1 GHMP kinases C terminal MCM PF00493.23 EGD98069.1 - 2.4e-99 331.0 0.1 3.6e-99 330.4 0.1 1.2 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 EGD98069.1 - 7.2e-38 129.3 0.2 1.5e-37 128.3 0.2 1.5 1 0 0 1 1 1 1 MCM OB domain MCM6_C PF18263.1 EGD98069.1 - 1e-32 112.5 2.0 2.6e-32 111.3 2.0 1.7 1 0 0 1 1 1 1 MCM6 C-terminal winged-helix domain MCM_lid PF17855.1 EGD98069.1 - 6e-24 84.3 0.5 1.7e-23 82.8 0.5 1.8 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 EGD98069.1 - 1e-20 74.3 1.4 2.7e-20 72.9 0.4 2.3 2 0 0 2 2 2 1 MCM N-terminal domain Mg_chelatase PF01078.21 EGD98069.1 - 7.2e-05 22.3 0.0 0.00037 19.9 0.0 2.2 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 EGD98069.1 - 0.0038 17.2 0.0 0.013 15.5 0.0 2.0 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 EGD98069.1 - 0.0059 16.5 0.0 0.014 15.2 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 EGD98069.1 - 0.018 14.8 0.0 0.043 13.5 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain GIDA_assoc PF13932.6 EGD98069.1 - 0.03 14.5 1.8 0.078 13.2 1.8 1.7 1 0 0 1 1 1 0 GidA associated domain EamA PF00892.20 EGD98070.1 - 1.2e-05 25.5 14.4 9e-05 22.7 14.4 1.9 1 1 0 1 1 1 1 EamA-like transporter family Trp_oprn_chp PF09534.10 EGD98070.1 - 0.026 14.3 0.0 1.5 8.5 0.0 2.1 2 0 0 2 2 2 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) TMEM234 PF10639.9 EGD98070.1 - 0.053 13.5 4.2 0.077 13.0 4.2 1.3 1 0 0 1 1 1 0 Putative transmembrane family 234 Voltage_CLC PF00654.20 EGD98071.1 - 1.3e-85 287.7 24.4 1.3e-85 287.7 24.4 1.5 2 0 0 2 2 2 1 Voltage gated chloride channel CBS PF00571.28 EGD98071.1 - 6.2e-06 26.6 0.0 0.00075 19.9 0.1 2.5 2 0 0 2 2 2 1 CBS domain ATPase_gene1 PF09527.10 EGD98071.1 - 0.079 13.1 7.5 4 7.7 1.2 3.7 3 0 0 3 3 3 0 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter CBFD_NFYB_HMF PF00808.23 EGD98072.1 - 7.5e-14 51.8 0.7 1.3e-13 51.0 0.0 1.8 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone UCR_TM PF02921.14 EGD98073.1 - 7.1e-11 42.4 0.5 1.6e-10 41.3 0.5 1.6 1 0 0 1 1 1 1 Ubiquinol cytochrome reductase transmembrane region Rieske PF00355.26 EGD98073.1 - 2e-10 40.5 0.0 3.3e-10 39.8 0.0 1.4 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain She9_MDM33 PF05546.11 EGD98074.1 - 6.6e-88 293.7 9.4 9e-88 293.3 9.4 1.2 1 0 0 1 1 1 1 She9 / Mdm33 family MBD_C PF14048.6 EGD98074.1 - 0.0076 16.9 0.3 0.031 15.0 0.1 2.2 2 0 0 2 2 2 1 C-terminal domain of methyl-CpG binding protein 2 and 3 DUF737 PF05300.11 EGD98074.1 - 0.011 16.0 7.8 0.059 13.7 7.5 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF737) PsbH PF00737.20 EGD98074.1 - 0.045 13.5 0.8 0.094 12.5 0.8 1.5 1 0 0 1 1 1 0 Photosystem II 10 kDa phosphoprotein SKA1 PF07160.12 EGD98074.1 - 0.88 9.4 9.6 0.043 13.7 2.7 2.0 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 1 Aminotran_1_2 PF00155.21 EGD98075.1 - 9.9e-40 136.8 0.0 1.1e-39 136.6 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 EGD98075.1 - 0.0048 16.2 0.0 0.01 15.1 0.0 1.5 2 0 0 2 2 2 1 Beta-eliminating lyase Aminotran_3 PF00202.21 EGD98075.1 - 0.029 13.0 0.0 0.048 12.3 0.0 1.3 1 0 0 1 1 1 0 Aminotransferase class-III RabGAP-TBC PF00566.18 EGD98075.1 - 0.033 13.9 0.0 0.059 13.0 0.0 1.3 1 0 0 1 1 1 0 Rab-GTPase-TBC domain Zn_clus PF00172.18 EGD98076.1 - 2.2e-16 59.7 30.3 3.7e-08 33.4 10.3 2.7 2 0 0 2 2 2 2 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EGD98076.1 - 9.6e-10 37.9 1.4 9.6e-10 37.9 1.4 2.2 3 0 0 3 3 3 1 Fungal specific transcription factor domain PNP_phzG_C PF10590.9 EGD98077.1 - 6.2e-21 74.2 4.4 7.3e-21 74.0 1.7 2.3 2 0 0 2 2 2 1 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region Putative_PNPOx PF01243.20 EGD98077.1 - 5e-11 42.6 0.0 4.3e-05 23.6 0.0 2.4 2 0 0 2 2 2 2 Pyridoxamine 5'-phosphate oxidase Pyridox_oxase_2 PF12766.7 EGD98077.1 - 0.011 16.3 0.1 0.097 13.3 0.1 2.1 1 1 0 1 1 1 0 Pyridoxamine 5'-phosphate oxidase PPR_2 PF13041.6 EGD98078.1 - 1.6e-41 140.3 12.0 1e-08 35.2 0.0 13.2 11 3 3 14 14 14 6 PPR repeat family PPR_3 PF13812.6 EGD98078.1 - 2.6e-31 107.5 0.5 0.00013 21.9 0.0 10.1 7 3 4 11 11 11 7 Pentatricopeptide repeat domain PPR PF01535.20 EGD98078.1 - 2.9e-23 80.4 15.1 0.0011 19.1 0.0 13.3 14 0 0 14 14 14 4 PPR repeat PPR_long PF17177.4 EGD98078.1 - 5.6e-19 68.3 8.2 1.4e-08 34.3 0.1 5.5 5 0 0 5 5 5 3 Pentacotripeptide-repeat region of PRORP PPR_1 PF12854.7 EGD98078.1 - 3.3e-17 61.9 0.2 9.3e-06 25.2 0.1 9.2 10 0 0 10 10 10 2 PPR repeat RPM2 PF08579.11 EGD98078.1 - 7.6e-08 32.8 0.1 8.8e-06 26.1 0.0 3.6 4 0 0 4 4 4 1 Mitochondrial ribonuclease P subunit (RPM2) ECSIT PF06239.11 EGD98078.1 - 0.026 13.6 0.8 2.2 7.4 0.0 3.6 4 0 0 4 4 4 0 Evolutionarily conserved signalling intermediate in Toll pathway F-box PF00646.33 EGD98079.1 - 2.3e-05 24.1 0.2 5.8e-05 22.9 0.2 1.6 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EGD98079.1 - 0.00025 20.8 1.2 0.00069 19.5 1.2 1.7 1 0 0 1 1 1 1 F-box-like F-box_4 PF15966.5 EGD98079.1 - 0.0017 18.3 1.5 0.0019 18.1 0.1 1.8 2 0 0 2 2 2 1 F-box Peptidase_S41 PF03572.18 EGD98080.1 - 2.1e-10 40.4 0.0 3.6e-10 39.7 0.0 1.3 1 0 0 1 1 1 1 Peptidase family S41 Ribosomal_L7Ae PF01248.26 EGD98081.1 - 4.8e-17 61.5 0.1 1.1e-16 60.3 0.1 1.6 1 1 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family RNase_P_pop3 PF08228.11 EGD98081.1 - 0.0048 17.0 0.4 0.014 15.4 0.4 1.8 1 1 0 1 1 1 1 RNase P subunit Pop3 RSN1_7TM PF02714.15 EGD98082.1 - 2.3e-92 309.2 23.0 1.2e-91 306.8 15.8 2.9 3 0 0 3 3 3 2 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 EGD98082.1 - 2.7e-43 147.4 3.3 3.5e-43 147.0 1.2 2.4 2 0 0 2 2 2 1 Late exocytosis, associated with Golgi transport PHM7_cyt PF14703.6 EGD98082.1 - 7.5e-37 127.3 0.0 1.5e-36 126.3 0.0 1.5 2 0 0 2 2 2 1 Cytosolic domain of 10TM putative phosphate transporter PHM7_ext PF12621.8 EGD98082.1 - 9e-29 99.5 0.0 1.9e-28 98.4 0.0 1.6 1 0 0 1 1 1 1 Extracellular tail, of 10TM putative phosphate transporter EHN PF06441.12 EGD98085.1 - 5.7e-36 123.2 2.9 6e-35 119.9 0.2 2.5 3 0 0 3 3 3 1 Epoxide hydrolase N terminus Abhydrolase_1 PF00561.20 EGD98085.1 - 1.8e-16 60.5 0.3 5.1e-16 59.1 0.1 1.8 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EGD98085.1 - 4.7e-07 30.6 2.3 8.8e-07 29.7 2.3 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family REJ PF02010.15 EGD98086.1 - 0.0072 15.2 0.1 0.0092 14.8 0.1 1.1 1 0 0 1 1 1 1 REJ domain RSN1_TM PF13967.6 EGD98087.1 - 0.023 14.4 0.0 0.028 14.2 0.0 1.1 1 0 0 1 1 1 0 Late exocytosis, associated with Golgi transport tRNA_NucTran2_2 PF13735.6 EGD98088.1 - 0.045 13.7 0.4 0.074 13.0 0.4 1.3 1 0 0 1 1 1 0 tRNA nucleotidyltransferase domain 2 putative Ribosomal_L17 PF01196.19 EGD98088.1 - 0.19 12.6 1.7 0.58 11.1 0.0 2.5 3 1 0 3 3 3 0 Ribosomal protein L17 DUF2849 PF11011.8 EGD98088.1 - 0.31 11.7 3.0 0.63 10.7 2.3 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF2849) Pyridox_oxase_2 PF12766.7 EGD98090.1 - 1e-22 80.6 0.0 1.8e-22 79.8 0.0 1.4 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase LRR_9 PF14580.6 EGD98091.1 - 6.6e-58 195.1 0.1 9.8e-58 194.5 0.1 1.3 1 0 0 1 1 1 1 Leucine-rich repeat LRR_8 PF13855.6 EGD98091.1 - 4.8e-10 39.0 14.9 5.7e-06 26.0 3.9 3.1 2 1 2 4 4 4 2 Leucine rich repeat LRR_4 PF12799.7 EGD98091.1 - 1.5e-05 25.2 11.9 0.00011 22.5 1.4 3.7 4 1 1 5 5 5 2 Leucine Rich repeats (2 copies) T4_Gp59_C PF08994.10 EGD98091.1 - 0.017 15.7 0.0 0.029 15.0 0.0 1.4 1 0 0 1 1 1 0 T4 gene Gp59 loader of gp41 DNA helicase C-term HTH_38 PF13936.6 EGD98091.1 - 0.049 13.4 0.2 0.1 12.3 0.2 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain UPF0128 PF03673.13 EGD98091.1 - 0.091 12.2 0.2 0.21 11.0 0.0 1.7 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0128) DUF4349 PF14257.6 EGD98091.1 - 0.14 11.6 1.3 0.23 10.9 1.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4349) GDA1_CD39 PF01150.17 EGD98092.1 - 6e-110 367.8 0.0 8.1e-110 367.4 0.0 1.1 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family Acyltransferase PF01553.21 EGD98093.1 - 6.9e-16 58.1 0.0 1.5e-15 57.0 0.0 1.5 1 0 0 1 1 1 1 Acyltransferase Pantoate_ligase PF02569.15 EGD98094.1 - 1.9e-91 306.0 0.0 2.2e-91 305.8 0.0 1.0 1 0 0 1 1 1 1 Pantoate-beta-alanine ligase Glyco_hydro_100 PF12899.7 EGD98094.1 - 0.033 12.9 0.0 0.043 12.5 0.0 1.1 1 0 0 1 1 1 0 Alkaline and neutral invertase DEAD PF00270.29 EGD98095.1 - 1.5e-40 138.9 0.0 2.5e-40 138.1 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EGD98095.1 - 8.5e-21 74.4 0.0 5.9e-20 71.7 0.0 2.2 1 1 0 2 2 2 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 EGD98095.1 - 2e-18 66.3 0.0 4.4e-18 65.3 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 EGD98095.1 - 4.1e-07 30.1 0.1 3.6e-06 27.1 0.0 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 EGD98095.1 - 0.013 14.8 0.4 0.022 14.0 0.0 1.6 2 0 0 2 2 2 0 ERCC3/RAD25/XPB C-terminal helicase PI3K_1B_p101 PF10486.9 EGD98095.1 - 1.5 6.5 9.1 0.14 9.9 4.3 1.6 2 0 0 2 2 2 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit WD40 PF00400.32 EGD98096.1 - 6.1e-11 42.7 10.9 0.00019 22.1 0.5 5.7 5 1 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EGD98096.1 - 0.00047 20.4 0.2 1.3 9.4 0.0 3.4 3 0 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain ParD_like PF11903.8 EGD98096.1 - 0.035 14.2 0.3 0.084 13.0 0.3 1.6 1 0 0 1 1 1 0 ParD-like antitoxin of type II bacterial toxin-antitoxin system Fungal_trans_2 PF11951.8 EGD98097.1 - 3e-09 36.2 5.1 5e-08 32.2 0.4 2.3 2 0 0 2 2 2 2 Fungal specific transcription factor domain Zn_clus PF00172.18 EGD98097.1 - 9.1e-06 25.7 10.1 2.3e-05 24.4 10.1 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SUIM_assoc PF16619.5 EGD98097.1 - 0.053 13.6 3.4 0.73 9.9 5.1 2.0 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 MFS_1 PF07690.16 EGD98098.1 - 2e-44 152.0 55.0 9.6e-44 149.7 53.6 2.2 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EGD98098.1 - 2e-10 40.2 35.3 6.2e-08 31.9 19.2 2.3 2 0 0 2 2 2 2 Sugar (and other) transporter TRI12 PF06609.13 EGD98098.1 - 1.3e-05 23.9 23.0 2e-05 23.3 23.0 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) CbtA PF09490.10 EGD98098.1 - 0.00094 19.0 4.9 0.0031 17.3 3.5 2.7 1 1 1 2 2 2 1 Probable cobalt transporter subunit (CbtA) GATase PF00117.28 EGD98099.1 - 3.7e-14 52.9 0.0 4.9e-14 52.5 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferase class-I GATase_3 PF07685.14 EGD98099.1 - 0.034 13.7 0.0 0.05 13.2 0.0 1.2 1 0 0 1 1 1 0 CobB/CobQ-like glutamine amidotransferase domain Peptidase_C26 PF07722.13 EGD98099.1 - 0.044 13.5 0.5 0.28 10.9 0.5 2.3 1 1 0 1 1 1 0 Peptidase C26 DUF775 PF05603.12 EGD98100.1 - 2.6e-65 219.7 0.0 2.9e-65 219.5 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF775) NUDIX PF00293.28 EGD98101.1 - 6.7e-12 45.6 0.0 1.3e-11 44.7 0.0 1.4 1 0 0 1 1 1 1 NUDIX domain DUF4743 PF15916.5 EGD98101.1 - 5.4e-10 39.3 0.0 7.8e-10 38.8 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4743) RNA_pol_Rpb8 PF03870.15 EGD98102.1 - 9.7e-47 158.7 0.0 1.1e-46 158.5 0.0 1.0 1 0 0 1 1 1 1 RNA polymerase Rpb8 PAXNEB PF05625.11 EGD98103.1 - 5.4e-119 397.6 0.0 6.2e-119 397.4 0.0 1.0 1 0 0 1 1 1 1 PAXNEB protein tRNA_int_endo PF01974.17 EGD98105.1 - 4.8e-15 55.4 0.0 1e-14 54.3 0.0 1.5 1 0 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain NMU PF02070.15 EGD98105.1 - 0.085 12.8 0.4 4 7.4 0.1 2.5 2 0 0 2 2 2 0 Neuromedin U UPF0086 PF01868.16 EGD98106.1 - 9.3e-32 108.8 0.1 1.6e-31 108.0 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function UPF0086 PGBA_C PF15437.6 EGD98106.1 - 0.51 10.7 4.2 17 5.9 0.7 2.3 2 0 0 2 2 2 0 Plasminogen-binding protein pgbA C-terminal Copper-bind PF00127.20 EGD98107.1 - 0.013 16.0 0.1 0.035 14.5 0.1 1.7 1 1 0 1 1 1 0 Copper binding proteins, plastocyanin/azurin family Apt1 PF10351.9 EGD98107.1 - 5.8 5.6 7.2 6.9 5.4 7.2 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Ank_2 PF12796.7 EGD98108.1 - 4.7e-67 222.6 4.8 3e-13 50.1 0.0 6.1 1 1 7 8 8 8 8 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EGD98108.1 - 2.1e-37 126.7 9.3 2.2e-10 40.5 0.1 7.3 5 1 3 8 8 8 7 Ankyrin repeats (many copies) Ank_4 PF13637.6 EGD98108.1 - 5.4e-37 125.7 8.1 1.9e-08 34.7 0.0 9.0 4 4 3 8 8 8 8 Ankyrin repeats (many copies) Ank_3 PF13606.6 EGD98108.1 - 3.3e-28 94.6 1.9 0.00018 21.7 0.0 10.8 11 0 0 11 11 11 6 Ankyrin repeat Ank PF00023.30 EGD98108.1 - 3.6e-27 93.6 0.6 0.049 14.1 0.0 10.6 10 1 0 10 10 10 8 Ankyrin repeat Trehalase_Ca-bi PF07492.11 EGD98108.1 - 3.8e-05 23.3 3.9 14 5.5 0.1 5.5 5 0 0 5 5 5 1 Neutral trehalase Ca2+ binding domain MFS_1 PF07690.16 EGD98109.1 - 3.8e-28 98.4 29.6 6e-28 97.8 29.6 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily Phos_pyr_kin PF08543.12 EGD98109.1 - 0.23 10.8 0.0 0.44 9.9 0.0 1.4 1 0 0 1 1 1 0 Phosphomethylpyrimidine kinase zf-C3HC4 PF00097.25 EGD98111.1 - 0.023 14.6 38.3 0.31 10.9 7.8 3.5 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) FYVE_2 PF02318.16 EGD98111.1 - 0.074 13.3 23.3 1.3 9.3 3.9 3.3 3 0 0 3 3 3 0 FYVE-type zinc finger zf-C3HC4_2 PF13923.6 EGD98111.1 - 0.19 11.6 38.5 0.37 10.7 6.5 3.5 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) TetR_C_19 PF17924.1 EGD98113.1 - 0.0066 17.0 0.1 0.07 13.7 0.1 2.0 1 1 1 2 2 2 1 Tetracyclin repressor-like, C-terminal domain DUF521 PF04412.13 EGD98113.1 - 0.14 10.9 0.0 0.15 10.7 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF521) Cofilin_ADF PF00241.20 EGD98114.1 - 5.2e-18 65.0 0.0 6.5e-18 64.7 0.0 1.1 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein MoCF_biosynth PF00994.24 EGD98115.1 - 1.3e-35 122.2 0.0 2.4e-35 121.3 0.0 1.4 1 0 0 1 1 1 1 Probable molybdopterin binding domain CinA_KH PF18146.1 EGD98115.1 - 0.08 13.1 0.0 0.21 11.8 0.0 1.7 2 0 0 2 2 2 0 Damage-inducible protein CinA KH domain Ras PF00071.22 EGD98116.1 - 7.5e-60 201.2 0.2 8.7e-60 201.0 0.2 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EGD98116.1 - 3.5e-20 72.4 0.0 5.3e-20 71.8 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EGD98116.1 - 2.2e-07 30.5 0.0 2.5e-07 30.3 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EGD98116.1 - 3.2e-05 23.6 0.1 0.00031 20.4 0.0 1.9 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EGD98116.1 - 4.9e-05 23.3 0.4 0.17 11.8 0.0 2.3 1 1 1 2 2 2 2 RsgA GTPase FeoB_N PF02421.18 EGD98116.1 - 0.001 18.6 0.0 0.0016 17.9 0.0 1.4 1 1 0 1 1 1 1 Ferrous iron transport protein B MMR_HSR1 PF01926.23 EGD98116.1 - 0.0021 18.1 0.0 0.0032 17.5 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase MMR_HSR1_Xtn PF16897.5 EGD98116.1 - 0.0031 17.5 0.1 0.0059 16.6 0.1 1.5 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain DUF2075 PF09848.9 EGD98116.1 - 0.18 11.0 0.4 11 5.1 0.1 2.0 1 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) CbiA PF01656.23 EGD98116.1 - 0.25 11.4 0.5 0.89 9.6 0.5 2.0 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain IstB_IS21 PF01695.17 EGD98116.1 - 0.32 10.7 1.2 3.4 7.3 0.2 2.2 1 1 1 2 2 2 0 IstB-like ATP binding protein adh_short PF00106.25 EGD98117.1 - 4e-53 179.8 0.0 5.2e-53 179.4 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EGD98117.1 - 3.5e-37 128.2 0.0 4.1e-37 128.0 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EGD98117.1 - 8e-13 48.7 0.0 1.1e-12 48.2 0.0 1.2 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 EGD98117.1 - 0.0018 17.4 0.2 0.0058 15.8 0.1 1.7 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein Sacchrp_dh_NADP PF03435.18 EGD98117.1 - 0.0056 16.9 0.1 0.011 16.0 0.1 1.5 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Lin0512_fam PF09585.10 EGD98117.1 - 0.092 12.8 0.4 1.5 8.9 0.0 2.2 2 0 0 2 2 2 0 Conserved hypothetical protein (Lin0512_fam) Epimerase PF01370.21 EGD98117.1 - 0.11 11.9 0.2 0.22 11.0 0.1 1.7 2 1 0 2 2 2 0 NAD dependent epimerase/dehydratase family Eno-Rase_NADH_b PF12242.8 EGD98117.1 - 0.14 11.9 0.1 0.39 10.5 0.1 1.7 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase GATA PF00320.27 EGD98119.1 - 9.1e-29 98.8 17.4 2.3e-15 55.9 4.8 2.4 2 0 0 2 2 2 2 GATA zinc finger TF_Zn_Ribbon PF08271.12 EGD98119.1 - 5.3e-08 32.3 3.8 0.0015 18.0 0.1 2.4 2 0 0 2 2 2 2 TFIIB zinc-binding Zn-ribbon_8 PF09723.10 EGD98119.1 - 0.00012 22.1 1.8 0.077 13.1 0.1 2.8 2 0 0 2 2 2 2 Zinc ribbon domain ArfGap PF01412.18 EGD98119.1 - 0.00047 20.2 1.9 0.99 9.5 0.1 2.6 2 0 0 2 2 2 2 Putative GTPase activating protein for Arf Auto_anti-p27 PF06677.12 EGD98119.1 - 0.003 17.7 6.4 0.27 11.4 0.9 2.5 2 0 0 2 2 2 2 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) TDP43_N PF18694.1 EGD98119.1 - 0.2 11.5 0.1 1.8 8.5 0.0 2.2 2 0 0 2 2 2 0 Transactive response DNA-binding protein N-terminal domain DZR PF12773.7 EGD98119.1 - 0.22 11.5 15.4 0.87 9.7 1.0 3.5 2 2 1 3 3 3 0 Double zinc ribbon zf-RRN7 PF11781.8 EGD98119.1 - 1.2 8.9 8.0 2.3 8.0 0.3 3.0 2 1 0 2 2 2 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 Eapp_C PF10238.9 EGD98119.1 - 1.6 8.8 8.0 28 4.8 4.7 2.8 2 0 0 2 2 2 0 E2F-associated phosphoprotein eIF-5_eIF-2B PF01873.17 EGD98119.1 - 1.8 8.5 4.4 23 4.9 0.7 2.4 2 0 0 2 2 2 0 Domain found in IF2B/IF5 OrfB_Zn_ribbon PF07282.11 EGD98119.1 - 3.1 7.8 14.1 0.85 9.6 0.3 3.2 3 0 0 3 3 3 0 Putative transposase DNA-binding domain COPI_assoc PF08507.10 EGD98120.1 - 4e-30 104.5 5.3 4.7e-30 104.3 5.3 1.0 1 0 0 1 1 1 1 COPI associated protein SPC12 PF06645.13 EGD98120.1 - 0.033 14.3 1.3 0.033 14.3 1.3 1.9 1 1 1 2 2 2 0 Microsomal signal peptidase 12 kDa subunit (SPC12) DAO PF01266.24 EGD98121.1 - 2.4e-33 116.2 0.2 3e-33 115.9 0.2 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EGD98121.1 - 0.00072 19.7 0.1 0.0016 18.6 0.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 EGD98121.1 - 0.0035 17.9 0.0 0.0081 16.7 0.0 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EGD98121.1 - 0.027 13.7 0.5 0.046 12.9 0.1 1.6 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Sacchrp_dh_NADP PF03435.18 EGD98121.1 - 0.028 14.7 0.2 0.092 13.0 0.1 1.9 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain Thi4 PF01946.17 EGD98121.1 - 0.047 12.9 0.1 0.047 12.9 0.1 1.6 2 0 0 2 2 2 0 Thi4 family NAD_binding_7 PF13241.6 EGD98121.1 - 0.072 13.5 0.0 0.12 12.8 0.0 1.6 1 1 0 1 1 1 0 Putative NAD(P)-binding GMC_oxred_N PF00732.19 EGD98121.1 - 0.12 11.7 0.2 0.27 10.6 0.0 1.8 2 0 0 2 2 2 0 GMC oxidoreductase ApbA PF02558.16 EGD98121.1 - 0.2 11.3 0.4 0.46 10.1 0.2 1.7 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA DUF1188 PF06690.11 EGD98121.1 - 0.2 11.2 0.1 16 4.9 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1188) Glyco_transf_54 PF04666.13 EGD98122.1 - 0.0077 15.1 0.0 0.49 9.2 0.0 2.1 2 0 0 2 2 2 2 N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region F-box_4 PF15966.5 EGD98125.1 - 6.3e-05 22.8 0.1 0.00011 22.0 0.1 1.4 1 0 0 1 1 1 1 F-box F-box PF00646.33 EGD98125.1 - 0.0013 18.5 1.5 0.0027 17.5 1.5 1.5 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EGD98125.1 - 0.0017 18.2 0.9 0.0037 17.1 0.9 1.5 1 0 0 1 1 1 1 F-box-like ssDBP_DBD PF18361.1 EGD98126.1 - 0.19 11.8 0.1 0.36 11.0 0.1 1.4 1 0 0 1 1 1 0 Single stranded DNA-binding protein ss DNA binding domain HNH_2 PF13391.6 EGD98127.1 - 0.0016 18.5 0.0 0.0035 17.4 0.0 1.6 1 0 0 1 1 1 1 HNH endonuclease peroxidase PF00141.23 EGD98128.1 - 1.4e-49 168.9 0.0 2.1e-49 168.3 0.0 1.2 1 0 0 1 1 1 1 Peroxidase ERG2_Sigma1R PF04622.12 EGD98129.1 - 6.7e-80 267.3 0.1 7.7e-80 267.1 0.1 1.0 1 0 0 1 1 1 1 ERG2 and Sigma1 receptor like protein zf-CSL PF05207.13 EGD98130.1 - 1.2e-18 66.5 1.1 2e-18 65.9 1.1 1.4 1 1 0 1 1 1 1 CSL zinc finger DnaJ PF00226.31 EGD98130.1 - 4.8e-13 49.0 0.1 4.9e-08 33.0 0.1 2.3 2 0 0 2 2 2 2 DnaJ domain PITH PF06201.13 EGD98131.1 - 3.8e-34 118.1 0.0 5.6e-34 117.6 0.0 1.3 1 0 0 1 1 1 1 PITH domain Thioredoxin PF00085.20 EGD98131.1 - 2.1e-24 85.5 0.0 4.1e-24 84.6 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 EGD98131.1 - 3.4e-05 24.1 0.0 0.00012 22.4 0.0 1.8 1 1 0 1 1 1 1 Thioredoxin-like Thioredoxin_2 PF13098.6 EGD98131.1 - 5.6e-05 23.5 0.1 0.00031 21.2 0.0 2.2 2 1 0 2 2 2 1 Thioredoxin-like domain AhpC-TSA PF00578.21 EGD98131.1 - 0.00063 19.7 0.0 0.0013 18.6 0.0 1.5 1 0 0 1 1 1 1 AhpC/TSA family Thioredoxin_7 PF13899.6 EGD98131.1 - 0.00071 19.7 0.1 0.0023 18.0 0.0 1.8 2 0 0 2 2 2 1 Thioredoxin-like OST3_OST6 PF04756.13 EGD98131.1 - 0.0013 18.1 0.0 0.002 17.5 0.0 1.2 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_9 PF14595.6 EGD98131.1 - 0.022 14.5 0.0 0.045 13.5 0.0 1.5 1 0 0 1 1 1 0 Thioredoxin Redoxin PF08534.10 EGD98131.1 - 0.13 11.9 0.0 0.25 11.1 0.0 1.4 1 0 0 1 1 1 0 Redoxin Glutaredoxin PF00462.24 EGD98131.1 - 0.15 12.3 0.0 0.37 11.1 0.0 1.6 1 0 0 1 1 1 0 Glutaredoxin Phosducin PF02114.16 EGD98131.1 - 0.18 10.7 0.0 0.27 10.1 0.0 1.2 1 0 0 1 1 1 0 Phosducin zf-C2H2 PF00096.26 EGD98133.1 - 2.9e-12 46.3 13.1 1.4e-06 28.4 0.9 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EGD98133.1 - 3.1e-07 30.7 10.7 0.0063 17.3 0.4 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EGD98133.1 - 1.9e-06 28.0 3.2 0.012 15.9 0.5 2.6 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-H2C2_2 PF13465.6 EGD98133.1 - 3.8e-06 27.1 3.5 3.8e-06 27.1 3.5 3.6 4 0 0 4 4 4 1 Zinc-finger double domain zf-C2H2_6 PF13912.6 EGD98133.1 - 0.00045 20.1 9.0 0.02 14.9 0.7 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger zf-met PF12874.7 EGD98133.1 - 0.0013 19.1 10.2 0.0081 16.5 0.3 3.0 3 0 0 3 3 3 2 Zinc-finger of C2H2 type zf-LYAR PF08790.11 EGD98133.1 - 0.0052 16.7 3.5 0.19 11.6 0.5 2.5 2 0 0 2 2 2 1 LYAR-type C2HC zinc finger zf_C2H2_ZHX PF18387.1 EGD98133.1 - 0.015 14.9 2.8 1.3 8.8 0.4 2.8 1 1 1 2 2 2 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-UBR PF02207.20 EGD98133.1 - 0.12 12.6 0.7 0.28 11.4 0.7 1.5 1 0 0 1 1 1 0 Putative zinc finger in N-recognin (UBR box) zf-C2H2_3rep PF18868.1 EGD98133.1 - 0.32 11.7 4.4 5.4 7.7 0.4 3.2 2 1 0 3 3 3 0 Zinc finger C2H2-type, 3 repeats zf_UBZ PF18439.1 EGD98133.1 - 0.34 10.5 1.9 1.1 8.9 0.1 2.4 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger zf-C2H2_2 PF12756.7 EGD98133.1 - 0.35 11.2 4.1 10 6.6 0.4 2.6 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-trcl PF13451.6 EGD98133.1 - 0.77 9.7 4.2 0.83 9.6 0.6 2.3 2 0 0 2 2 2 0 Probable zinc-ribbon domain zf-C2H2_11 PF16622.5 EGD98133.1 - 0.9 9.3 8.5 7.3 6.4 0.1 2.5 2 0 0 2 2 2 0 zinc-finger C2H2-type zf-BED PF02892.15 EGD98133.1 - 2.1 8.4 5.1 1.2 9.3 1.4 2.3 1 1 1 2 2 2 0 BED zinc finger DUF629 PF04780.12 EGD98133.1 - 2.6 6.5 4.5 13 4.2 0.1 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF629) Zn-ribbon_8 PF09723.10 EGD98133.1 - 2.8 8.1 4.4 6.6 6.9 0.6 2.3 1 1 1 2 2 2 0 Zinc ribbon domain zf-C2HE PF16278.5 EGD98133.1 - 5.5 7.5 6.8 5.5e+02 1.1 7.0 2.6 1 1 0 1 1 1 0 C2HE / C2H2 / C2HC zinc-binding finger Diphthami_syn_2 PF01902.17 EGD98134.1 - 1.7e-18 66.9 0.0 3.6e-05 23.4 0.0 4.2 3 1 0 3 3 3 3 Diphthamide synthase Ribonuc_L-PSP PF01042.21 EGD98134.1 - 4.4e-11 42.9 0.1 9.5e-06 25.6 0.0 4.0 3 1 0 3 3 3 2 Endoribonuclease L-PSP Pkinase PF00069.25 EGD98135.1 - 6.3e-11 42.1 0.0 1.1e-10 41.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD98135.1 - 1.5e-07 31.0 0.0 7.3e-07 28.7 0.0 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase APH PF01636.23 EGD98135.1 - 2.5e-07 30.9 1.5 0.00056 19.9 0.3 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 EGD98135.1 - 0.00015 21.2 0.0 0.00022 20.6 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 EGD98135.1 - 0.078 12.6 0.0 0.14 11.8 0.0 1.4 1 0 0 1 1 1 0 RIO1 family Choline_kinase PF01633.20 EGD98135.1 - 0.14 11.7 0.0 0.46 10.0 0.0 1.7 2 0 0 2 2 2 0 Choline/ethanolamine kinase MFS_Mycoplasma PF07672.13 EGD98137.1 - 0.098 11.9 3.4 0.2 10.9 0.2 2.4 2 0 0 2 2 2 0 Mycoplasma MFS transporter DHHC PF01529.20 EGD98137.1 - 3.5 7.8 4.7 1.4 9.0 1.3 2.1 2 0 0 2 2 2 0 DHHC palmitoyltransferase DUF3543 PF12063.8 EGD98138.1 - 3e-97 324.9 0.1 5.5e-97 324.1 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3543) Pkinase PF00069.25 EGD98138.1 - 2.2e-60 204.2 0.0 4.7e-60 203.2 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD98138.1 - 9.5e-42 143.1 0.0 3.5e-41 141.2 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EGD98138.1 - 0.05 13.5 0.9 0.14 12.1 0.1 2.2 2 0 0 2 2 2 0 Phosphotransferase enzyme family AA_permease_2 PF13520.6 EGD98139.1 - 4.5e-88 295.9 33.4 5.8e-88 295.5 33.4 1.2 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EGD98139.1 - 8.7e-22 77.3 30.6 1.6e-21 76.5 30.7 1.3 1 1 0 1 1 1 1 Amino acid permease ERAP1_C PF11838.8 EGD98140.1 - 1.1e-86 291.2 0.3 1.3e-84 284.5 0.1 2.5 2 0 0 2 2 2 2 ERAP1-like C-terminal domain Peptidase_M1 PF01433.20 EGD98140.1 - 4.4e-84 281.4 3.1 6.9e-84 280.8 3.1 1.3 1 0 0 1 1 1 1 Peptidase family M1 domain Peptidase_M1_N PF17900.1 EGD98140.1 - 1.2e-52 178.8 1.2 2.2e-52 177.9 1.2 1.5 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain DUF2808 PF10989.8 EGD98140.1 - 0.049 13.6 0.0 0.13 12.2 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2808) DEAD PF00270.29 EGD98141.1 - 3.5e-46 157.2 0.0 1.3e-45 155.3 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EGD98141.1 - 4.6e-30 104.2 0.1 2e-29 102.2 0.1 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EGD98141.1 - 0.007 16.4 0.0 0.014 15.4 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit PRAI PF00697.22 EGD98141.1 - 0.019 14.7 0.0 0.035 13.9 0.0 1.3 1 0 0 1 1 1 0 N-(5'phosphoribosyl)anthranilate (PRA) isomerase DUF2986 PF11661.8 EGD98141.1 - 2.3 8.8 10.0 0.13 12.8 3.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2986) Neur_chan_memb PF02932.16 EGD98141.1 - 7.3 6.6 5.1 18 5.3 5.1 1.6 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region UPF0164 PF03687.13 EGD98142.1 - 0.12 11.2 0.0 0.19 10.5 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0164) p450 PF00067.22 EGD98143.1 - 3e-21 75.7 0.1 9e-21 74.1 0.0 1.7 2 0 0 2 2 2 1 Cytochrome P450 FAD_binding_4 PF01565.23 EGD98144.1 - 9.9e-21 73.9 3.5 3.1e-20 72.3 3.5 1.9 1 1 0 1 1 1 1 FAD binding domain Suf PF05843.14 EGD98145.1 - 0.00049 20.2 4.9 0.00071 19.7 0.2 2.8 3 0 0 3 3 3 1 Suppressor of forked protein (Suf) TPR_14 PF13428.6 EGD98145.1 - 0.0082 16.9 0.4 0.0082 16.9 0.4 6.8 8 1 1 9 9 9 1 Tetratricopeptide repeat c-SKI_SMAD_bind PF08782.10 EGD98145.1 - 0.011 16.0 1.4 1.6 9.0 0.0 3.5 2 1 0 2 2 2 0 c-SKI Smad4 binding domain DUF4810 PF16068.5 EGD98145.1 - 0.048 14.2 0.0 3.5 8.2 0.0 3.2 2 1 1 3 3 3 0 Domain of unknown function (DUF4810) Fe_hyd_SSU PF02256.17 EGD98145.1 - 0.25 11.4 0.8 8.7 6.5 0.1 2.8 2 0 0 2 2 2 0 Iron hydrogenase small subunit Mitoc_mL59 PF18126.1 EGD98146.1 - 3.4e-49 166.4 1.8 6.2e-49 165.6 1.8 1.4 1 1 0 1 1 1 1 Mitochondrial ribosomal protein mL59 MOSC PF03473.17 EGD98147.1 - 8.1e-30 103.5 0.0 1.4e-29 102.8 0.0 1.4 1 0 0 1 1 1 1 MOSC domain MOSC_N PF03476.16 EGD98147.1 - 1.4e-25 89.5 0.0 2.4e-25 88.7 0.0 1.4 1 0 0 1 1 1 1 MOSC N-terminal beta barrel domain Aminotran_5 PF00266.19 EGD98147.1 - 1.1e-24 87.2 0.0 1.6e-24 86.6 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V MARVEL PF01284.23 EGD98148.1 - 0.0012 18.9 0.4 0.0023 18.0 0.4 1.4 1 0 0 1 1 1 1 Membrane-associating domain Kei1 PF08552.11 EGD98148.1 - 0.0029 17.5 0.0 0.0044 16.9 0.0 1.2 1 0 0 1 1 1 1 Inositolphosphorylceramide synthase subunit Kei1 RR_TM4-6 PF06459.12 EGD98149.1 - 1 9.1 7.2 1 9.2 7.2 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Pap_E4 PF02711.14 EGD98149.1 - 2.6 9.1 6.9 3.7 8.6 6.9 1.2 1 0 0 1 1 1 0 E4 protein Presenilin PF01080.17 EGD98149.1 - 5.4 5.7 4.4 5.7 5.6 4.4 1.1 1 0 0 1 1 1 0 Presenilin PAP2 PF01569.21 EGD98150.1 - 1e-20 73.9 0.1 1e-20 73.9 0.1 1.6 2 0 0 2 2 2 1 PAP2 superfamily Git3 PF11710.8 EGD98150.1 - 0.29 10.9 2.2 2.8 7.7 0.3 2.7 3 0 0 3 3 3 0 G protein-coupled glucose receptor regulating Gpa2 PARM PF17061.5 EGD98152.1 - 0.012 15.7 7.0 0.015 15.4 7.0 1.1 1 0 0 1 1 1 0 PARM But2 PF09792.9 EGD98153.1 - 2.6e-47 160.8 0.1 3.3e-47 160.4 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin 3 binding protein But2 C-terminal domain Lactamase_B PF00753.27 EGD98154.1 - 0.00011 22.2 0.1 0.00024 21.1 0.1 1.6 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Cytochrom_C552 PF02335.15 EGD98154.1 - 0.081 11.8 0.1 0.12 11.2 0.1 1.2 1 0 0 1 1 1 0 Cytochrome c552 NGP1NT PF08153.12 EGD98156.1 - 3.7e-50 169.4 0.2 5.7e-50 168.8 0.2 1.3 1 0 0 1 1 1 1 NGP1NT (NUC091) domain MMR_HSR1 PF01926.23 EGD98156.1 - 2.4e-16 59.8 0.0 1.5e-13 50.8 0.0 2.5 2 0 0 2 2 2 2 50S ribosome-binding GTPase FeoB_N PF02421.18 EGD98156.1 - 1.7e-05 24.4 0.0 5.7e-05 22.7 0.0 1.8 2 0 0 2 2 2 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 EGD98156.1 - 0.00074 19.5 0.0 0.0017 18.3 0.0 1.5 1 0 0 1 1 1 1 RsgA GTPase Arf PF00025.21 EGD98156.1 - 0.0094 15.4 0.0 0.3 10.5 0.0 2.2 2 0 0 2 2 2 1 ADP-ribosylation factor family Dynamin_N PF00350.23 EGD98156.1 - 0.029 14.4 0.5 0.84 9.7 0.0 3.0 3 1 1 4 4 4 0 Dynamin family Nop14 PF04147.12 EGD98156.1 - 6.8 4.8 7.8 10 4.2 7.8 1.1 1 0 0 1 1 1 0 Nop14-like family Gpr1_Fun34_YaaH PF01184.19 EGD98157.1 - 5.7e-49 166.5 9.6 8.5e-49 166.0 9.6 1.2 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family YrhC PF14143.6 EGD98157.1 - 0.023 14.8 4.5 0.059 13.5 4.5 1.7 1 0 0 1 1 1 0 YrhC-like protein p450 PF00067.22 EGD98158.1 - 1.3e-76 258.2 0.0 1.6e-76 258.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Pkinase PF00069.25 EGD98159.1 - 3.8e-39 134.7 0.0 1.5e-38 132.6 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD98159.1 - 4.4e-28 98.3 0.0 6.3e-28 97.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EGD98159.1 - 0.00089 18.1 0.0 0.0013 17.6 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 EGD98159.1 - 0.071 12.4 0.0 0.14 11.5 0.0 1.4 1 0 0 1 1 1 0 Kinase-like Kdo PF06293.14 EGD98159.1 - 0.15 11.4 0.0 0.29 10.5 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Prefoldin_3 PF13758.6 EGD98160.1 - 2.9e-33 113.8 0.1 8.6e-33 112.4 0.1 1.9 1 0 0 1 1 1 1 Prefoldin subunit DUF3835 PF12927.7 EGD98160.1 - 4.9e-25 88.2 11.2 2.3e-23 82.8 0.4 3.9 3 0 0 3 3 3 2 Domain of unknown function (DUF3835) Lzipper-MIP1 PF14389.6 EGD98160.1 - 0.016 15.5 0.8 14 6.0 0.0 3.8 3 0 0 3 3 3 0 Leucine-zipper of ternary complex factor MIP1 Prefoldin_2 PF01920.20 EGD98160.1 - 0.061 13.3 0.9 10 6.1 0.0 3.3 3 0 0 3 3 3 0 Prefoldin subunit Zip PF02535.22 EGD98161.1 - 3.1e-39 135.1 26.1 2.6e-38 132.1 26.1 2.1 1 1 0 1 1 1 1 ZIP Zinc transporter Lactamase_B PF00753.27 EGD98161.1 - 0.27 11.2 5.5 0.12 12.4 0.5 2.6 3 0 0 3 3 3 0 Metallo-beta-lactamase superfamily MAT1 PF06391.13 EGD98162.1 - 1.4e-41 142.6 16.0 1.8e-41 142.3 16.0 1.1 1 0 0 1 1 1 1 CDK-activating kinase assembly factor MAT1 zf-C3HC4_5 PF17121.5 EGD98162.1 - 1.9e-32 110.9 8.5 3e-32 110.3 8.5 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EGD98162.1 - 0.00013 21.7 5.1 0.00024 20.9 5.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EGD98162.1 - 0.00016 21.5 3.7 0.00041 20.1 3.7 1.7 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EGD98162.1 - 0.0014 18.5 4.1 0.0029 17.4 4.1 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EGD98162.1 - 0.0017 18.6 6.2 0.0033 17.7 6.2 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_4 PF14570.6 EGD98162.1 - 0.011 15.5 5.1 0.069 13.0 1.9 2.3 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain Zn_ribbon_17 PF17120.5 EGD98162.1 - 0.017 14.7 1.4 0.034 13.8 1.4 1.5 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-RING_5 PF14634.6 EGD98162.1 - 0.029 14.3 7.2 0.23 11.4 7.7 2.1 1 1 1 2 2 2 0 zinc-RING finger domain DUF3797 PF12677.7 EGD98162.1 - 0.069 13.1 2.3 0.16 11.9 2.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3797) zf-RING_UBOX PF13445.6 EGD98162.1 - 0.33 11.0 6.8 0.78 9.8 6.8 1.6 1 0 0 1 1 1 0 RING-type zinc-finger MTHFR_C PF12225.8 EGD98162.1 - 0.5 10.1 2.9 2.9 7.6 2.9 2.2 1 1 0 1 1 1 0 Methylene-tetrahydrofolate reductase C terminal Prok-RING_4 PF14447.6 EGD98162.1 - 1.7 8.6 8.0 41 4.2 8.8 2.3 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 adh_short PF00106.25 EGD98164.1 - 2e-24 86.2 0.0 2.7e-24 85.7 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EGD98164.1 - 9.1e-15 54.8 0.0 1.3e-14 54.3 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EGD98164.1 - 0.00035 20.5 0.1 0.0011 18.9 0.0 1.8 2 0 0 2 2 2 1 KR domain DUF1263 PF06882.12 EGD98164.1 - 0.052 13.6 0.0 0.13 12.3 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1263) DUF1776 PF08643.10 EGD98164.1 - 0.086 12.2 0.0 0.4 10.0 0.0 1.8 1 1 0 1 1 1 0 Fungal family of unknown function (DUF1776) NAD_binding_10 PF13460.6 EGD98164.1 - 0.16 11.9 0.0 0.28 11.0 0.0 1.4 1 0 0 1 1 1 0 NAD(P)H-binding F-box-like PF12937.7 EGD98166.1 - 6e-05 22.9 0.1 0.00017 21.4 0.1 1.9 1 0 0 1 1 1 1 F-box-like NHR2 PF08788.11 EGD98166.1 - 0.11 12.3 0.0 0.24 11.2 0.0 1.5 1 0 0 1 1 1 0 NHR2 domain like CoaE PF01121.20 EGD98167.1 - 0.13 11.9 0.0 0.26 11.0 0.0 1.3 1 0 0 1 1 1 0 Dephospho-CoA kinase PEX11 PF05648.14 EGD98168.1 - 4.2e-34 117.9 0.0 5.8e-34 117.5 0.0 1.2 1 0 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) FMN_red PF03358.15 EGD98169.1 - 3.9e-09 36.4 0.0 5.3e-09 36.0 0.0 1.2 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 EGD98169.1 - 1.5e-07 31.4 0.0 1.9e-07 31.0 0.0 1.1 1 0 0 1 1 1 1 Flavodoxin-like fold Flavodoxin_1 PF00258.25 EGD98169.1 - 2.3e-05 24.6 0.3 0.00029 21.1 0.3 2.2 1 1 0 1 1 1 1 Flavodoxin Flavodoxin_5 PF12724.7 EGD98169.1 - 0.00083 19.6 0.0 0.003 17.8 0.0 1.8 1 1 1 2 2 2 1 Flavodoxin domain NPL4 PF05021.15 EGD98170.1 - 1.2e-138 461.7 0.0 1.5e-138 461.4 0.0 1.1 1 0 0 1 1 1 1 NPL4 family zf-NPL4 PF05020.15 EGD98170.1 - 1.6e-68 229.4 0.1 2.5e-68 228.8 0.1 1.3 1 0 0 1 1 1 1 NPL4 family, putative zinc binding region Kinesin PF00225.23 EGD98171.1 - 1.1e-13 50.8 0.0 2.5e-13 49.7 0.0 1.5 1 0 0 1 1 1 1 Kinesin motor domain Herpes_UL14 PF03580.14 EGD98171.1 - 0.0085 16.4 1.8 0.0085 16.4 1.8 2.0 2 0 0 2 2 2 1 Herpesvirus UL14-like protein ArgoL2 PF16488.5 EGD98171.1 - 0.078 13.3 0.3 0.23 11.8 0.3 1.9 1 0 0 1 1 1 0 Argonaute linker 2 domain DUF5565 PF17720.1 EGD98172.1 - 0.14 11.0 0.0 0.2 10.5 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5565) MBD PF01429.19 EGD98172.1 - 0.15 11.8 0.2 2.1 8.1 0.0 2.3 2 0 0 2 2 2 0 Methyl-CpG binding domain Tim17 PF02466.19 EGD98173.1 - 0.00017 21.9 2.2 0.00023 21.5 1.5 1.6 1 1 1 2 2 2 1 Tim17/Tim22/Tim23/Pmp24 family Dsh_C PF12316.8 EGD98175.1 - 4.2 7.7 9.9 1.3 9.4 0.4 2.2 2 0 0 2 2 2 0 Segment polarity protein dishevelled (Dsh) C terminal cNMPbd_u2 PF16643.5 EGD98176.1 - 6.2e-38 130.7 8.9 6.2e-38 130.7 8.9 2.7 3 0 0 3 3 3 1 Unstructured region on cNMP-binding protein cNMP_binding PF00027.29 EGD98176.1 - 8.3e-35 118.7 0.0 1.5e-20 73.0 0.0 2.5 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain LRR_6 PF13516.6 EGD98176.1 - 1.1e-09 37.6 9.0 1.6 9.0 0.0 8.1 10 0 0 10 10 10 4 Leucine Rich repeat LRR_4 PF12799.7 EGD98176.1 - 1.7e-05 25.1 8.3 0.043 14.3 0.1 6.4 5 2 4 9 9 9 3 Leucine Rich repeats (2 copies) F-box-like PF12937.7 EGD98176.1 - 5.4e-05 23.0 1.4 0.00011 22.0 0.5 2.1 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 EGD98176.1 - 0.0018 18.1 7.0 0.0021 17.9 0.7 3.4 3 0 0 3 3 3 1 F-box domain LRR_1 PF00560.33 EGD98176.1 - 0.022 15.2 12.0 61 4.7 0.1 7.7 10 0 0 10 10 10 0 Leucine Rich Repeat SAM_Ste50p PF09235.10 EGD98176.1 - 0.12 12.7 3.4 9.8 6.5 0.5 3.9 3 2 0 3 3 3 0 Ste50p, sterile alpha motif Zn_clus PF00172.18 EGD98177.1 - 1.1e-07 31.8 7.8 1.9e-07 31.1 7.8 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain ZapB PF06005.12 EGD98177.1 - 0.016 15.7 0.7 0.016 15.7 0.7 2.7 3 1 0 3 3 3 0 Cell division protein ZapB YabA PF06156.13 EGD98177.1 - 0.016 15.9 0.4 0.059 14.0 0.0 2.1 2 0 0 2 2 2 0 Initiation control protein YabA NRBF2 PF08961.10 EGD98177.1 - 0.037 13.6 0.2 0.037 13.6 0.2 2.6 3 0 0 3 3 3 0 Nuclear receptor-binding factor 2, autophagy regulator RasGAP_C PF03836.15 EGD98177.1 - 0.08 13.1 2.9 0.13 12.4 0.0 2.1 2 0 0 2 2 2 0 RasGAP C-terminus TSC22 PF01166.18 EGD98177.1 - 1.6 9.1 3.5 0.51 10.7 0.2 1.8 2 0 0 2 2 2 0 TSC-22/dip/bun family PikAIV_N PF18605.1 EGD98177.1 - 4.3 7.0 10.7 1.5 8.5 1.1 2.4 1 1 1 2 2 2 0 Narbonolide/10-deoxymethynolide synthase PikA4 N-terminal domain Slx4 PF09494.10 EGD98178.1 - 4.1e-25 87.5 0.4 1e-24 86.2 0.5 1.7 2 0 0 2 2 2 1 Slx4 endonuclease CGI-121 PF08617.10 EGD98179.1 - 5.8e-59 198.8 0.5 6.7e-59 198.6 0.5 1.0 1 0 0 1 1 1 1 Kinase binding protein CGI-121 Bax1-I PF01027.20 EGD98180.1 - 6.7e-33 114.3 10.3 6.7e-33 114.3 10.3 1.4 2 0 0 2 2 2 1 Inhibitor of apoptosis-promoting Bax1 Cutinase PF01083.22 EGD98182.1 - 3.5e-37 128.1 0.0 5e-37 127.6 0.0 1.2 1 0 0 1 1 1 1 Cutinase Abhydrolase_2 PF02230.16 EGD98182.1 - 0.00066 19.6 0.0 0.0012 18.7 0.0 1.4 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase PE-PPE PF08237.11 EGD98182.1 - 0.068 12.7 0.1 0.25 10.9 0.1 1.9 1 1 0 1 1 1 0 PE-PPE domain Abhydrolase_1 PF00561.20 EGD98182.1 - 0.21 11.2 0.0 0.25 10.9 0.0 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold RRM_1 PF00076.22 EGD98183.1 - 1e-15 57.3 0.0 1.5e-15 56.8 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EGD98183.1 - 0.0061 16.1 0.0 0.0088 15.6 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Shadoo PF14999.6 EGD98183.1 - 8.9 6.4 10.2 14 5.8 7.7 2.0 2 0 0 2 2 2 0 Shadow of prion protein, neuroprotective Glyco_hydro_76 PF03663.14 EGD98184.1 - 2.5e-24 86.5 0.2 3.1e-16 59.8 0.1 2.4 2 0 0 2 2 2 2 Glycosyl hydrolase family 76 DUF2236 PF09995.9 EGD98185.1 - 1.5e-08 35.2 0.0 3e-08 34.1 0.0 1.6 1 1 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2236) DUF2205 PF10224.9 EGD98189.1 - 5.8e-33 112.7 0.4 1e-32 111.9 0.4 1.4 1 0 0 1 1 1 1 Short coiled-coil protein YabA PF06156.13 EGD98189.1 - 0.017 15.8 0.3 0.029 15.0 0.3 1.3 1 0 0 1 1 1 0 Initiation control protein YabA DUF4208 PF13907.6 EGD98189.1 - 0.021 15.2 0.1 0.033 14.6 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4208) DivIC PF04977.15 EGD98189.1 - 0.027 14.2 0.4 0.043 13.6 0.4 1.3 1 0 0 1 1 1 0 Septum formation initiator DUF4201 PF13870.6 EGD98189.1 - 0.027 14.2 0.4 0.038 13.7 0.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4201) CASP_C PF08172.12 EGD98189.1 - 0.038 13.3 0.9 0.038 13.3 0.9 2.0 2 0 0 2 2 2 0 CASP C terminal HALZ PF02183.18 EGD98189.1 - 0.043 14.0 2.8 0.097 12.9 0.2 2.2 1 1 1 2 2 2 0 Homeobox associated leucine zipper PI3K_P85_iSH2 PF16454.5 EGD98189.1 - 0.048 13.3 0.2 0.06 12.9 0.2 1.2 1 0 0 1 1 1 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain Prefoldin PF02996.17 EGD98189.1 - 0.073 13.0 0.6 0.11 12.4 0.6 1.3 1 0 0 1 1 1 0 Prefoldin subunit NAM-associated PF14303.6 EGD98189.1 - 2.5 8.8 8.8 6.3 7.5 8.9 1.8 1 1 0 1 1 1 0 No apical meristem-associated C-terminal domain 14-3-3 PF00244.20 EGD98193.1 - 9.8e-105 349.0 7.3 1.2e-104 348.7 7.3 1.1 1 0 0 1 1 1 1 14-3-3 protein IATP PF04568.12 EGD98194.1 - 1e-22 80.4 1.7 1.2e-22 80.2 1.7 1.0 1 0 0 1 1 1 1 Mitochondrial ATPase inhibitor, IATP Spot_14 PF07084.12 EGD98194.1 - 0.047 13.8 0.4 0.055 13.6 0.4 1.1 1 0 0 1 1 1 0 Thyroid hormone-inducible hepatic protein Spot 14 Nsp1_C PF05064.13 EGD98195.1 - 1.3e-42 144.3 3.4 1.3e-42 144.3 3.4 1.6 2 0 0 2 2 1 1 Nsp1-like C-terminal region Nucleoporin_FG PF13634.6 EGD98195.1 - 0.0086 16.9 22.6 0.0086 16.9 22.6 5.6 1 1 2 3 3 1 1 Nucleoporin FG repeat region ParB PF08775.10 EGD98195.1 - 0.033 14.7 0.4 0.033 14.7 0.4 2.0 2 1 0 2 2 2 0 ParB family HIP1_clath_bdg PF16515.5 EGD98195.1 - 0.12 13.0 14.1 1.4 9.6 6.0 2.4 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF2935 PF11155.8 EGD98195.1 - 0.27 11.6 1.3 3.1 8.1 1.2 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF2935) DUF4407 PF14362.6 EGD98195.1 - 0.32 10.3 8.1 0.6 9.4 8.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF4200 PF13863.6 EGD98195.1 - 0.39 11.1 11.9 0.2 12.1 6.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) OmpH PF03938.14 EGD98195.1 - 0.43 10.9 12.5 2.3 8.6 0.2 2.3 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) FlaC_arch PF05377.11 EGD98195.1 - 0.43 11.0 9.1 0.89 10.0 0.4 3.1 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) Baculo_PEP_C PF04513.12 EGD98195.1 - 0.87 9.6 7.0 1.4 8.9 5.4 2.0 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus AAA_13 PF13166.6 EGD98195.1 - 1.1 7.8 8.2 2.2 6.8 7.8 1.5 1 1 0 1 1 1 0 AAA domain Med21 PF11221.8 EGD98195.1 - 1.1 9.5 13.2 35 4.6 13.2 3.0 1 1 0 1 1 1 0 Subunit 21 of Mediator complex IFT57 PF10498.9 EGD98195.1 - 1.3 7.9 10.7 0.13 11.2 3.9 2.0 2 0 0 2 2 2 0 Intra-flagellar transport protein 57 DUF1664 PF07889.12 EGD98195.1 - 1.5 8.8 8.7 1.6 8.8 0.4 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) Laminin_II PF06009.12 EGD98195.1 - 2.1 8.3 10.5 3.8 7.5 3.0 2.4 1 1 2 3 3 3 0 Laminin Domain II CK2S PF15011.6 EGD98195.1 - 2.2 8.1 7.6 1.7 8.5 3.4 2.3 2 0 0 2 2 2 0 Casein Kinase 2 substrate CREPT PF16566.5 EGD98195.1 - 3.9 7.6 6.9 0.98 9.6 1.7 2.1 2 0 0 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour FliT PF05400.13 EGD98195.1 - 4.4 8.2 6.9 1.1 10.1 1.1 2.6 1 1 2 3 3 2 0 Flagellar protein FliT Occludin_ELL PF07303.13 EGD98195.1 - 5.3 7.8 5.3 6.6 7.5 1.9 2.2 2 0 0 2 2 2 0 Occludin homology domain GAT PF03127.14 EGD98195.1 - 5.4 7.4 6.7 12 6.3 0.2 2.8 1 1 1 2 2 2 0 GAT domain V-SNARE PF05008.15 EGD98195.1 - 5.8 7.4 10.0 1 9.7 0.7 3.1 2 1 1 3 3 3 0 Vesicle transport v-SNARE protein N-terminus Spc7 PF08317.11 EGD98195.1 - 6.4 5.6 14.7 1.9 7.3 7.5 2.1 2 0 0 2 2 2 0 Spc7 kinetochore protein BRE1 PF08647.11 EGD98195.1 - 9.5 6.4 9.9 9.7 6.3 4.8 2.2 2 0 0 2 2 2 0 BRE1 E3 ubiquitin ligase DUF5102 PF17104.5 EGD98196.1 - 1.1e-114 383.4 1.6 1.1e-114 383.4 1.6 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF5102) DUF4543 PF15076.6 EGD98196.1 - 0.17 12.0 0.8 0.29 11.3 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4543) zf-MIZ PF02891.20 EGD98197.1 - 1.4e-10 40.7 0.1 3.4e-10 39.5 0.1 1.6 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger DUF281 PF03436.13 EGD98197.1 - 0.44 11.0 0.1 0.44 11.0 0.1 3.2 4 0 0 4 4 4 0 Domain of unknown function (DUF281) SH3_1 PF00018.28 EGD98198.1 - 1.1e-09 37.7 0.0 2.2e-09 36.8 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EGD98198.1 - 4.8e-09 35.9 0.2 1.1e-08 34.7 0.2 1.6 1 0 0 1 1 1 1 Variant SH3 domain SAM_2 PF07647.17 EGD98198.1 - 2.3e-08 34.0 0.1 4.9e-08 33.0 0.1 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SH3_2 PF07653.17 EGD98198.1 - 0.00021 20.9 0.1 0.00042 19.9 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain SAM_1 PF00536.30 EGD98198.1 - 0.0021 18.4 0.1 0.0041 17.5 0.1 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Gastrin PF00918.17 EGD98198.1 - 0.2 12.6 2.3 0.58 11.1 0.1 3.0 2 0 0 2 2 2 0 Gastrin/cholecystokinin family Ribosomal_L14 PF00238.19 EGD98200.1 - 2.4e-31 108.4 0.0 2.7e-31 108.2 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e Endonuc-FokI_C PF09254.11 EGD98200.1 - 0.17 11.1 0.0 0.24 10.6 0.0 1.1 1 0 0 1 1 1 0 Restriction endonuclease FokI, C terminal Hist_deacetyl PF00850.19 EGD98201.1 - 3.1e-82 276.5 0.1 6.9e-82 275.3 0.0 1.6 2 0 0 2 2 2 1 Histone deacetylase domain JAB PF01398.21 EGD98202.1 - 1.1e-33 115.7 0.0 2.5e-33 114.5 0.0 1.6 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.6 EGD98202.1 - 4.8e-12 46.3 0.8 7.6e-12 45.6 0.8 1.4 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function Prok-JAB PF14464.6 EGD98202.1 - 6.4e-08 32.4 0.0 4.6e-07 29.6 0.0 2.1 2 0 0 2 2 2 1 Prokaryotic homologs of the JAB domain NIF PF03031.18 EGD98204.1 - 1.2e-40 138.9 0.0 1.7e-40 138.4 0.0 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase Fungal_trans PF04082.18 EGD98205.1 - 2.2e-16 59.7 0.0 5.8e-16 58.3 0.0 1.8 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EGD98205.1 - 2.3e-06 27.6 6.3 4.6e-06 26.7 6.3 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain F-box-like PF12937.7 EGD98207.1 - 2e-05 24.4 1.2 5.2e-05 23.1 1.2 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EGD98207.1 - 0.0061 16.4 1.4 0.012 15.4 1.4 1.5 1 0 0 1 1 1 1 F-box domain WD40 PF00400.32 EGD98207.1 - 0.007 17.2 0.0 11 7.1 0.1 4.4 4 0 0 4 4 4 1 WD domain, G-beta repeat EspF PF04806.12 EGD98207.1 - 0.038 14.4 12.5 0.52 10.8 3.9 3.5 2 0 0 2 2 2 0 EspF protein repeat Fungal_trans PF04082.18 EGD98208.1 - 4.4e-08 32.5 0.7 7.7e-08 31.7 0.7 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EGD98208.1 - 8.9e-06 25.7 8.8 2.1e-05 24.5 8.8 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SUIM_assoc PF16619.5 EGD98208.1 - 0.6 10.2 4.2 0.67 10.1 1.0 2.5 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Pkinase PF00069.25 EGD98210.1 - 5e-69 232.6 0.0 1e-68 231.6 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD98210.1 - 3.5e-34 118.3 0.0 2.9e-33 115.3 0.0 2.3 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EGD98210.1 - 0.0012 18.2 0.3 0.8 9.0 0.0 2.6 3 0 0 3 3 3 2 Kinase-like RIO1 PF01163.22 EGD98210.1 - 0.07 12.7 0.2 0.15 11.6 0.2 1.6 1 0 0 1 1 1 0 RIO1 family Pkinase_fungal PF17667.1 EGD98210.1 - 0.3 9.8 2.2 0.38 9.5 0.0 2.2 3 0 0 3 3 3 0 Fungal protein kinase MFS_1 PF07690.16 EGD98211.1 - 7.1e-28 97.5 34.3 1.1e-19 70.6 20.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EGD98211.1 - 9.7e-20 70.8 14.6 9.9e-19 67.5 14.6 2.2 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EGD98213.1 - 6.6e-13 48.3 18.6 6.6e-13 48.3 18.6 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EGD98213.1 - 0.00033 19.6 8.1 0.00046 19.2 8.1 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EGD98215.1 - 5.5e-06 25.6 12.2 6e-06 25.4 12.2 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF3789 PF12664.7 EGD98215.1 - 0.95 9.2 9.8 2 8.2 0.3 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3789) M20_dimer PF07687.14 EGD98216.1 - 0.94 9.4 6.1 3.4 7.6 0.3 3.1 4 0 0 4 4 4 0 Peptidase dimerisation domain HAMP PF00672.25 EGD98217.1 - 2.5e-36 123.8 15.9 6.7e-08 32.8 0.5 7.9 6 2 2 8 8 8 5 HAMP domain HATPase_c PF02518.26 EGD98217.1 - 2.9e-33 114.7 0.0 1.5e-32 112.4 0.0 2.3 2 0 0 2 2 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 EGD98217.1 - 1.1e-24 86.8 1.2 6e-24 84.4 0.5 2.7 2 0 0 2 2 2 1 Response regulator receiver domain HisKA PF00512.25 EGD98217.1 - 7.1e-17 61.2 4.1 2.3e-16 59.6 0.1 3.9 4 0 0 4 4 4 1 His Kinase A (phospho-acceptor) domain DUF4279 PF14106.6 EGD98217.1 - 1e-05 25.7 0.0 3.6 7.8 0.0 5.5 5 1 0 5 5 5 1 Domain of unknown function (DUF4279) DUF3829 PF12889.7 EGD98217.1 - 0.00094 18.7 13.8 0.037 13.5 0.2 5.0 5 1 1 6 6 6 2 Protein of unknown function (DUF3829) Syntaxin_2 PF14523.6 EGD98217.1 - 0.0014 18.9 14.9 7.3 7.0 0.0 6.8 3 2 2 6 6 6 1 Syntaxin-like protein DUF948 PF06103.11 EGD98217.1 - 0.0017 18.6 47.7 1.3 9.3 0.1 9.1 3 1 3 6 6 6 2 Bacterial protein of unknown function (DUF948) Fib_alpha PF08702.10 EGD98217.1 - 0.021 15.0 34.0 2.8 8.1 0.1 7.3 6 1 1 7 7 7 0 Fibrinogen alpha/beta chain family NOD PF06816.13 EGD98217.1 - 0.049 13.2 0.0 6.1 6.5 0.0 2.7 2 0 0 2 2 2 0 NOTCH protein IcmF_C PF06744.12 EGD98217.1 - 0.06 13.0 0.0 0.19 11.3 0.0 1.8 1 0 0 1 1 1 0 Type VI secretion protein IcmF C-terminal Vps52 PF04129.12 EGD98217.1 - 0.066 11.9 4.4 4.9 5.8 0.2 3.8 4 0 0 4 4 4 0 Vps52 / Sac2 family Gp-FAR-1 PF05823.12 EGD98217.1 - 0.1 12.9 4.3 34 4.8 0.0 4.7 1 1 3 5 5 5 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) SpoIIID PF12116.8 EGD98217.1 - 0.11 12.6 2.8 25 5.0 0.1 4.5 4 0 0 4 4 4 0 Stage III sporulation protein D WXG100 PF06013.12 EGD98217.1 - 0.44 10.8 19.5 11 6.3 0.2 7.1 6 2 1 7 7 7 0 Proteins of 100 residues with WXG CMD PF02627.20 EGD98217.1 - 0.6 10.2 2.2 8.7 6.5 0.1 3.7 4 0 0 4 4 4 0 Carboxymuconolactone decarboxylase family DUF2877 PF11392.8 EGD98217.1 - 1.3 9.8 9.0 11 6.7 0.2 4.6 4 0 0 4 4 4 0 Protein of unknown function (DUF2877) CENP-F_leu_zip PF10473.9 EGD98217.1 - 1.7 8.7 27.3 3.5 7.6 0.2 7.5 5 3 2 8 8 7 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 GhoS PF11080.8 EGD98217.1 - 3.7 7.6 7.4 4.3 7.4 0.1 3.9 4 0 0 4 4 4 0 Endoribonuclease GhoS GLE1 PF07817.13 EGD98217.1 - 3.9 6.6 11.4 21 4.2 0.5 4.3 3 1 2 5 5 5 0 GLE1-like protein AdHead_fibreRBD PF16812.5 EGD98217.1 - 3.9 7.2 11.9 0.047 13.5 0.4 3.3 4 0 0 4 4 4 0 C-terminal head domain of the fowl adenovirus type 1 long fibre tRNA-synt_2d PF01409.20 EGD98218.1 - 2.3e-88 295.8 0.0 3.1e-88 295.4 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II core domain (F) PheRS_DBD3 PF18553.1 EGD98218.1 - 1.3e-16 60.6 0.5 1.3e-16 60.6 0.5 2.0 2 0 0 2 2 2 1 PheRS DNA binding domain 3 tRNA-synt_2 PF00152.20 EGD98218.1 - 6.1e-05 22.3 0.1 0.0033 16.6 0.0 2.8 3 0 0 3 3 3 1 tRNA synthetases class II (D, K and N) tRNA_synthFbeta PF17759.1 EGD98218.1 - 7e-05 22.4 0.0 0.043 13.3 0.0 2.3 2 0 0 2 2 2 2 Phenylalanyl tRNA synthetase beta chain CLM domain PheRS_DBD2 PF18554.1 EGD98218.1 - 0.0015 18.5 0.3 0.0039 17.1 0.3 1.8 1 0 0 1 1 1 1 PheRS DNA binding domain 2 DUF2564 PF10819.8 EGD98218.1 - 0.012 15.9 0.1 0.031 14.6 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2564) Ribosomal_S21e PF01249.18 EGD98219.1 - 1.3e-30 105.3 0.3 3e-30 104.2 0.3 1.5 1 1 0 1 1 1 1 Ribosomal protein S21e Scm3 PF10384.9 EGD98219.1 - 0.084 12.6 0.1 0.23 11.2 0.0 1.8 2 0 0 2 2 2 0 Centromere protein Scm3 NUDIX PF00293.28 EGD98220.1 - 7.4e-07 29.3 0.0 3.1e-06 27.2 0.0 2.2 1 1 0 1 1 1 1 NUDIX domain IMPDH PF00478.25 EGD98221.1 - 5.7e-130 433.3 5.2 6.8e-130 433.1 5.2 1.0 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain CBS PF00571.28 EGD98221.1 - 1e-18 67.5 0.1 1.4e-09 38.3 0.0 2.6 2 0 0 2 2 2 2 CBS domain FMN_dh PF01070.18 EGD98221.1 - 7.9e-08 31.7 0.7 2e-07 30.4 0.7 1.6 2 0 0 2 2 2 1 FMN-dependent dehydrogenase NMO PF03060.15 EGD98221.1 - 4.1e-06 26.4 9.1 0.0025 17.3 6.3 3.0 2 1 1 3 3 3 2 Nitronate monooxygenase His_biosynth PF00977.21 EGD98221.1 - 9.5e-05 22.0 2.3 0.0003 20.3 2.3 1.7 1 1 0 1 1 1 1 Histidine biosynthesis protein PK PF00224.21 EGD98221.1 - 0.0013 17.7 0.0 0.0026 16.7 0.0 1.5 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain Aldolase PF01081.19 EGD98221.1 - 0.012 15.1 1.7 0.067 12.6 0.2 2.4 1 1 0 2 2 2 0 KDPG and KHG aldolase ThiG PF05690.14 EGD98221.1 - 0.031 13.6 0.5 0.031 13.6 0.5 1.7 2 0 0 2 2 2 0 Thiazole biosynthesis protein ThiG YpsA PF06908.11 EGD98221.1 - 0.032 14.2 0.0 0.056 13.4 0.0 1.3 1 0 0 1 1 1 0 YspA SLOG family Glu_synthase PF01645.17 EGD98221.1 - 0.053 12.7 3.3 0.094 11.8 3.3 1.4 1 0 0 1 1 1 0 Conserved region in glutamate synthase EAL PF00563.20 EGD98221.1 - 0.16 11.5 0.5 17 4.8 0.0 2.5 2 1 0 2 2 2 0 EAL domain G3P_antiterm PF04309.12 EGD98221.1 - 0.28 10.6 2.0 2.7 7.4 0.2 2.5 2 0 0 2 2 2 0 Glycerol-3-phosphate responsive antiterminator RasGAP PF00616.19 EGD98222.1 - 5.7e-52 176.5 0.0 1.2e-51 175.4 0.0 1.6 1 0 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase RasGAP_C PF03836.15 EGD98222.1 - 2e-50 170.5 4.7 7.7e-50 168.6 4.7 2.1 1 0 0 1 1 1 1 RasGAP C-terminus CH PF00307.31 EGD98222.1 - 2.6e-13 50.1 0.0 1.7e-12 47.5 0.0 2.3 2 0 0 2 2 2 1 Calponin homology (CH) domain IQ PF00612.27 EGD98222.1 - 4.5e-10 38.4 41.3 0.22 11.4 0.0 14.9 16 1 1 17 17 17 4 IQ calmodulin-binding motif CAMSAP_CH PF11971.8 EGD98222.1 - 0.013 15.3 0.0 0.14 12.0 0.0 2.4 2 0 0 2 2 2 0 CAMSAP CH domain DUF1033 PF06279.11 EGD98222.1 - 0.068 13.4 0.3 0.71 10.1 0.1 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF1033) IZUMO PF15005.6 EGD98222.1 - 0.074 13.6 0.1 0.38 11.3 0.1 2.3 1 0 0 1 1 1 0 Izumo sperm-egg fusion, Ig domain-associated Trypan_PARP PF05887.11 EGD98222.1 - 0.081 12.9 4.9 0.17 11.8 4.9 1.4 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) MbeB_N PF04837.12 EGD98222.1 - 6.9 7.1 6.2 53 4.2 0.2 3.7 3 0 0 3 3 3 0 MbeB-like, N-term conserved region ENTH PF01417.20 EGD98223.1 - 2.5e-46 156.8 0.1 4e-46 156.1 0.1 1.3 1 0 0 1 1 1 1 ENTH domain ANTH PF07651.16 EGD98223.1 - 0.001 18.1 0.0 0.0016 17.5 0.0 1.2 1 0 0 1 1 1 1 ANTH domain SH3_1 PF00018.28 EGD98224.1 - 3.2e-11 42.6 0.0 5.6e-11 41.9 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EGD98224.1 - 6.4e-09 35.5 0.0 1.2e-08 34.6 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EGD98224.1 - 4.2e-07 29.6 0.0 7.5e-07 28.7 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain MFS_1 PF07690.16 EGD98225.1 - 7.2e-26 90.9 50.3 9.3e-15 54.4 24.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 EGD98225.1 - 9.2e-07 27.8 13.3 9.2e-07 27.8 13.3 2.3 1 1 1 2 2 2 2 MFS/sugar transport protein MFS_1_like PF12832.7 EGD98225.1 - 9.6e-06 24.7 25.5 3e-05 23.1 10.2 2.1 1 1 1 2 2 2 2 MFS_1 like family 7TM_GPCR_Srh PF10318.9 EGD98225.1 - 3.8e-05 22.9 1.4 3.8e-05 22.9 1.4 2.9 4 1 0 4 4 4 1 Serpentine type 7TM GPCR chemoreceptor Srh Pkinase PF00069.25 EGD98228.1 - 3.4e-66 223.3 0.0 5.4e-66 222.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD98228.1 - 1.3e-34 119.6 0.0 1.1e-33 116.7 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EGD98228.1 - 2.8e-06 26.4 0.1 5.2e-06 25.5 0.1 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 EGD98228.1 - 3.9e-06 26.4 0.1 2.3e-05 23.9 0.1 2.1 1 1 0 1 1 1 1 Kinase-like APH PF01636.23 EGD98228.1 - 2e-05 24.7 0.0 0.005 16.8 0.1 2.6 1 1 1 2 2 2 2 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 EGD98228.1 - 0.0099 15.0 0.1 0.018 14.1 0.1 1.3 1 0 0 1 1 1 1 Seadornavirus VP7 Kdo PF06293.14 EGD98228.1 - 0.074 12.4 0.8 0.57 9.5 0.1 2.2 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family RRM_1 PF00076.22 EGD98229.1 - 5.7e-18 64.5 0.1 8.9e-09 35.1 0.0 3.2 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 EGD98229.1 - 0.014 15.4 0.9 0.24 11.5 0.0 2.6 2 1 1 3 3 3 0 RNA binding motif Tubulin PF00091.25 EGD98230.1 - 1e-68 231.4 0.0 2.2e-68 230.4 0.0 1.5 2 0 0 2 2 2 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EGD98230.1 - 1.3e-43 148.2 0.1 2.1e-43 147.5 0.1 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 EGD98230.1 - 2.1e-05 24.8 0.0 5.7e-05 23.4 0.0 1.7 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_2 PF13809.6 EGD98230.1 - 0.00085 18.6 0.0 0.034 13.4 0.0 2.1 2 0 0 2 2 2 1 Tubulin like Tubulin_3 PF14881.6 EGD98230.1 - 0.0043 16.8 0.0 0.0092 15.7 0.0 1.6 1 0 0 1 1 1 1 Tubulin domain Aldedh PF00171.22 EGD98231.1 - 2.2e-107 359.4 0.0 2.7e-107 359.1 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF2236 PF09995.9 EGD98232.1 - 1.5e-06 28.6 0.0 2.2e-06 28.0 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2236) AGT PF11440.8 EGD98232.1 - 0.054 12.5 0.0 0.076 12.0 0.0 1.2 1 0 0 1 1 1 0 DNA alpha-glucosyltransferase Methyltransf_31 PF13847.6 EGD98233.1 - 2.5e-10 40.3 0.0 3.7e-10 39.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EGD98233.1 - 1.1e-09 38.9 0.0 2e-09 38.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EGD98233.1 - 4.1e-08 33.2 0.0 5.5e-08 32.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EGD98233.1 - 5e-08 33.6 0.0 9.3e-08 32.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EGD98233.1 - 5.3e-05 23.8 0.0 0.0001 22.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EGD98233.1 - 0.032 13.5 0.0 0.075 12.4 0.0 1.6 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family CheR PF01739.18 EGD98233.1 - 0.045 13.2 0.0 0.075 12.5 0.0 1.3 1 0 0 1 1 1 0 CheR methyltransferase, SAM binding domain Isochorismatase PF00857.20 EGD98234.1 - 3.2e-34 118.6 0.1 1.1e-33 116.8 0.1 1.8 2 0 0 2 2 2 1 Isochorismatase family Iso_dh PF00180.20 EGD98234.1 - 3.8e-13 49.3 0.0 1.4e-07 31.1 0.0 2.4 2 1 0 2 2 2 2 Isocitrate/isopropylmalate dehydrogenase TK PF00265.18 EGD98234.1 - 0.0072 16.2 0.0 0.045 13.6 0.0 2.1 2 0 0 2 2 2 1 Thymidine kinase Methyltransf_25 PF13649.6 EGD98235.1 - 1.7e-10 41.4 0.0 6.2e-10 39.7 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EGD98235.1 - 4e-06 27.4 0.0 1.2e-05 25.9 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 EGD98235.1 - 6.7e-05 22.8 0.0 0.0001 22.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EGD98235.1 - 7.6e-05 23.4 0.0 0.00011 22.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EGD98235.1 - 0.00048 19.9 0.0 0.0006 19.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EGD98235.1 - 0.064 12.6 0.0 0.083 12.2 0.0 1.1 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Abhydrolase_6 PF12697.7 EGD98236.1 - 5e-08 33.8 0.0 6.1e-08 33.5 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Aminotran_1_2 PF00155.21 EGD98236.1 - 0.1 11.7 0.0 0.17 11.1 0.0 1.2 1 0 0 1 1 1 0 Aminotransferase class I and II Rad60-SLD PF11976.8 EGD98238.1 - 5.8e-21 74.1 0.2 6.7e-21 73.9 0.2 1.1 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 EGD98238.1 - 7.2e-12 44.9 0.1 8.1e-12 44.7 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin family MTCP1 PF08991.10 EGD98239.1 - 4.6e-27 94.0 11.7 5.2e-27 93.9 11.7 1.0 1 0 0 1 1 1 1 Mature-T-Cell Proliferation I type CHCH PF06747.13 EGD98239.1 - 0.021 15.0 6.5 0.034 14.3 6.5 1.4 1 0 0 1 1 1 0 CHCH domain Nup84_Nup100 PF04121.13 EGD98240.1 - 1.3e-177 592.2 3.8 1.7e-177 591.8 3.8 1.1 1 0 0 1 1 1 1 Nuclear pore protein 84 / 107 HBM PF16591.5 EGD98240.1 - 0.011 15.2 0.8 0.011 15.2 0.8 1.9 2 0 0 2 2 2 0 Helical bimodular sensor domain PEP-utilizers_C PF02896.18 EGD98240.1 - 0.097 11.8 0.0 0.2 10.7 0.0 1.5 1 0 0 1 1 1 0 PEP-utilising enzyme, TIM barrel domain Cation_ATPase_C PF00689.21 EGD98242.1 - 5.8e-46 156.5 4.4 5.8e-46 156.5 4.4 2.9 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 EGD98242.1 - 1.2e-34 119.5 4.1 1.2e-34 119.5 4.1 3.0 3 1 0 3 3 3 1 E1-E2 ATPase Hydrolase PF00702.26 EGD98242.1 - 2.9e-16 60.4 1.0 1.7e-15 57.9 1.0 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EGD98242.1 - 1.2e-08 34.9 0.1 2.5e-08 33.9 0.1 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 EGD98242.1 - 2e-06 27.4 0.2 1.5e-05 24.6 0.0 2.4 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 EGD98242.1 - 2.5e-05 24.2 0.6 7.8e-05 22.5 0.4 1.9 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase DUF1774 PF08611.10 EGD98242.1 - 0.11 12.8 5.3 0.11 12.8 0.4 2.9 2 0 0 2 2 2 0 Fungal protein of unknown function (DUF1774) LptF_LptG PF03739.14 EGD98242.1 - 0.65 8.8 10.9 0.074 11.9 6.2 1.8 2 0 0 2 2 2 0 Lipopolysaccharide export system permease LptF/LptG BatA PF07584.11 EGD98242.1 - 2.8 8.4 5.9 3.7 8.0 0.1 3.5 4 0 0 4 4 4 0 Aerotolerance regulator N-terminal Nucleo_P87 PF07267.11 EGD98243.1 - 0.52 9.1 11.0 0.59 8.9 11.0 1.0 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 TMEM171 PF15471.6 EGD98243.1 - 1.2 8.0 4.3 1.6 7.6 4.3 1.2 1 0 0 1 1 1 0 Transmembrane protein family 171 Peptidase_S64 PF08192.11 EGD98243.1 - 4.3 5.7 10.2 4.8 5.5 10.2 1.0 1 0 0 1 1 1 0 Peptidase family S64 GREB1 PF15782.5 EGD98243.1 - 8.9 3.3 10.0 11 3.0 10.0 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Ligase_CoA PF00549.19 EGD98244.1 - 7.1e-34 116.8 2.3 7.8e-18 64.8 0.1 2.2 2 0 0 2 2 2 2 CoA-ligase Succ_CoA_lig PF13607.6 EGD98244.1 - 1e-10 41.5 0.4 8.2e-09 35.4 0.1 2.3 2 0 0 2 2 2 2 Succinyl-CoA ligase like flavodoxin domain 4HBT PF03061.22 EGD98245.1 - 7.8e-11 42.2 0.0 1.3e-10 41.5 0.0 1.3 1 0 0 1 1 1 1 Thioesterase superfamily V-ATPase_C PF03223.15 EGD98246.1 - 1.3e-122 409.8 0.0 1.5e-122 409.6 0.0 1.0 1 0 0 1 1 1 1 V-ATPase subunit C mRNA_cap_C PF03919.15 EGD98246.1 - 0.039 14.6 0.0 0.091 13.4 0.0 1.6 1 0 0 1 1 1 0 mRNA capping enzyme, C-terminal domain APS_kinase PF01583.20 EGD98247.1 - 1.1e-51 174.9 0.0 1.8e-51 174.1 0.0 1.4 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_18 PF13238.6 EGD98247.1 - 9.4e-07 29.4 0.1 6.2e-05 23.6 0.0 2.5 2 1 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EGD98247.1 - 0.00031 20.9 2.6 0.00054 20.1 0.0 2.6 2 2 0 2 2 2 1 AAA domain AAA_29 PF13555.6 EGD98247.1 - 0.002 17.8 0.6 0.0052 16.5 0.0 1.9 2 0 0 2 2 2 1 P-loop containing region of AAA domain Zeta_toxin PF06414.12 EGD98247.1 - 0.016 14.5 1.2 0.04 13.2 0.0 2.1 2 0 0 2 2 2 0 Zeta toxin ABC_tran PF00005.27 EGD98247.1 - 0.045 14.3 2.0 0.071 13.6 0.0 2.3 3 1 0 3 3 3 0 ABC transporter CbiA PF01656.23 EGD98247.1 - 0.07 13.2 0.0 0.21 11.7 0.0 1.9 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain RNA_helicase PF00910.22 EGD98247.1 - 0.18 12.2 0.0 0.38 11.1 0.0 1.6 1 0 0 1 1 1 0 RNA helicase AAA_16 PF13191.6 EGD98247.1 - 0.56 10.6 7.5 1.2 9.5 0.0 2.4 2 1 0 2 2 2 0 AAA ATPase domain AAA_23 PF13476.6 EGD98247.1 - 2.2 8.7 4.6 11 6.5 0.0 2.3 2 0 0 2 2 2 0 AAA domain GCV_T PF01571.21 EGD98248.1 - 6.9e-78 261.6 0.0 9.6e-78 261.1 0.0 1.2 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain GCV_T_C PF08669.11 EGD98248.1 - 2.7e-17 62.5 0.5 1.2e-16 60.4 0.3 2.1 2 0 0 2 2 2 1 Glycine cleavage T-protein C-terminal barrel domain Aa_trans PF01490.18 EGD98249.1 - 1.2e-26 93.4 34.8 2e-26 92.6 34.8 1.4 1 1 0 1 1 1 1 Transmembrane amino acid transporter protein DUF973 PF06157.11 EGD98249.1 - 2.2 7.2 12.0 1.4 7.9 1.3 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF973) DUF3040 PF11239.8 EGD98249.1 - 2.4 8.5 0.0 2.4 8.5 0.0 4.2 5 0 0 5 5 5 0 Protein of unknown function (DUF3040) S1FA PF04689.13 EGD98249.1 - 4.4 7.5 5.3 1 9.6 0.7 2.3 2 0 0 2 2 2 0 DNA binding protein S1FA Ank_2 PF12796.7 EGD98250.1 - 6.2e-34 116.4 0.4 1e-13 51.6 0.0 4.1 3 1 1 4 4 4 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EGD98250.1 - 6.2e-24 84.0 0.5 1.5e-07 31.8 0.0 5.7 4 1 1 5 5 5 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 EGD98250.1 - 7.8e-20 70.7 0.0 1.5e-08 34.7 0.0 4.9 2 2 3 5 5 5 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EGD98250.1 - 6.9e-19 66.0 2.5 0.013 16.0 0.0 8.4 10 0 0 10 10 10 4 Ankyrin repeat Ank PF00023.30 EGD98250.1 - 2e-15 56.4 1.3 0.017 15.6 0.0 6.6 6 0 0 6 6 6 4 Ankyrin repeat Fe-ADH_2 PF13685.6 EGD98253.1 - 0.24 11.1 2.1 0.19 11.4 0.1 1.8 2 1 0 2 2 2 0 Iron-containing alcohol dehydrogenase Syntaxin-6_N PF09177.11 EGD98253.1 - 0.51 10.9 12.0 2.2 8.9 5.1 2.8 2 0 0 2 2 2 0 Syntaxin 6, N-terminal DUF948 PF06103.11 EGD98253.1 - 2.2 8.6 16.7 0.97 9.7 1.4 4.4 3 2 2 5 5 5 0 Bacterial protein of unknown function (DUF948) DUF812 PF05667.11 EGD98253.1 - 2.5 6.9 13.6 0.31 9.9 5.4 2.0 1 1 0 2 2 2 0 Protein of unknown function (DUF812) RasGEF_N_2 PF14663.6 EGD98254.1 - 0.042 14.3 0.4 1.8 9.0 0.0 3.4 3 0 0 3 3 3 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain DUF4407 PF14362.6 EGD98254.1 - 3.6 6.8 15.2 5.4 6.3 6.0 3.0 2 1 1 3 3 3 0 Domain of unknown function (DUF4407) BLOC1S3 PF15753.5 EGD98254.1 - 4.4 7.4 10.5 1 9.4 1.0 3.1 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex 1 subunit 3 HrpB7 PF09486.10 EGD98254.1 - 6.4 7.2 12.7 1.8 9.0 3.5 2.7 2 0 0 2 2 2 0 Bacterial type III secretion protein (HrpB7) PTN_MK_C PF01091.18 EGD98255.1 - 0.058 13.8 0.1 1.8 9.0 0.0 2.1 2 0 0 2 2 2 0 PTN/MK heparin-binding protein family, C-terminal domain Guanylate_kin PF00625.21 EGD98256.1 - 9.4e-44 149.3 0.0 1.1e-43 149.0 0.0 1.0 1 0 0 1 1 1 1 Guanylate kinase Vac_ImportDeg PF09783.9 EGD98257.1 - 1.1e-66 223.7 1.0 1.4e-66 223.3 1.0 1.1 1 0 0 1 1 1 1 Vacuolar import and degradation protein DUF3738 PF12543.8 EGD98257.1 - 0.097 12.8 1.7 0.17 12.0 1.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3738) Mago_nashi PF02792.14 EGD98258.1 - 6.9e-71 236.9 0.3 8.2e-71 236.7 0.3 1.0 1 0 0 1 1 1 1 Mago nashi protein Adaptin_N PF01602.20 EGD98259.1 - 1e-94 318.0 12.0 2e-94 317.0 12.0 1.4 1 0 0 1 1 1 1 Adaptin N terminal region Coatamer_beta_C PF07718.12 EGD98259.1 - 1.4e-57 193.5 0.6 3.2e-57 192.4 0.6 1.7 1 0 0 1 1 1 1 Coatomer beta C-terminal region Coatomer_b_Cpla PF14806.6 EGD98259.1 - 9.3e-56 187.3 0.1 4.4e-55 185.1 0.0 2.2 2 0 0 2 2 2 1 Coatomer beta subunit appendage platform Cnd1 PF12717.7 EGD98259.1 - 6.4e-13 49.1 11.4 8.2e-10 39.0 0.0 3.5 2 1 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EGD98259.1 - 7.5e-10 39.1 0.4 4.8e-06 26.9 0.0 5.2 5 1 1 6 6 6 3 HEAT repeats HEAT PF02985.22 EGD98259.1 - 0.00035 20.6 1.1 1.7 9.1 0.1 5.2 5 0 0 5 5 5 1 HEAT repeat HEAT_EZ PF13513.6 EGD98259.1 - 0.0033 17.9 4.3 0.036 14.6 0.1 4.4 4 0 0 4 4 4 1 HEAT-like repeat AP4E_app_platf PF14807.6 EGD98259.1 - 0.0058 17.0 0.2 0.02 15.2 0.2 2.0 1 0 0 1 1 1 1 Adaptin AP4 complex epsilon appendage platform Arm PF00514.23 EGD98259.1 - 0.033 14.2 2.4 16 5.7 0.0 5.2 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat NBD94 PF16830.5 EGD98259.1 - 0.41 11.0 3.5 7.7 7.0 0.9 2.7 2 0 0 2 2 2 0 Nucleotide-Binding Domain 94 of RH DUF4239 PF14023.6 EGD98259.1 - 1.8 8.2 7.6 0.53 10.0 3.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4239) DUF1542 PF07564.11 EGD98259.1 - 3.1 8.0 8.3 0.19 11.9 2.1 2.2 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1542) DUF2569 PF10754.9 EGD98260.1 - 0.11 13.0 13.0 0.14 12.6 3.9 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF2569) LrgB PF04172.16 EGD98260.1 - 1.7 8.1 12.5 0.036 13.6 4.1 2.3 2 1 0 2 2 2 0 LrgB-like family DAGK_cat PF00781.24 EGD98262.1 - 2.2e-26 91.9 0.1 3.3e-26 91.4 0.1 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain Pkinase PF00069.25 EGD98263.1 - 4.5e-72 242.6 0.0 7.7e-72 241.8 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD98263.1 - 3.6e-41 141.2 0.0 9.2e-41 139.8 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase KA1 PF02149.19 EGD98263.1 - 4.2e-17 61.7 0.4 8e-17 60.8 0.4 1.5 1 0 0 1 1 1 1 Kinase associated domain 1 Haspin_kinase PF12330.8 EGD98263.1 - 1.1e-06 27.8 0.0 1.9e-06 27.1 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 EGD98263.1 - 4e-06 26.3 0.1 7.4e-06 25.5 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EGD98263.1 - 6.8e-06 25.6 0.0 9.8e-05 21.8 0.0 2.4 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 EGD98263.1 - 0.0027 17.7 0.1 0.16 11.9 0.1 2.4 1 1 1 2 2 2 1 Phosphotransferase enzyme family WaaY PF06176.11 EGD98263.1 - 0.012 15.3 0.1 0.02 14.5 0.1 1.2 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) RIO1 PF01163.22 EGD98263.1 - 0.025 14.2 0.5 0.073 12.7 0.5 1.7 1 1 0 1 1 1 0 RIO1 family YrbL-PhoP_reg PF10707.9 EGD98263.1 - 0.11 12.0 0.0 0.23 11.0 0.0 1.5 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL DUF1604 PF07713.13 EGD98264.1 - 3.7e-43 145.2 9.9 2.7e-42 142.5 2.3 4.1 4 0 0 4 4 4 1 Protein of unknown function (DUF1604) G-patch PF01585.23 EGD98264.1 - 1.7e-07 31.0 1.5 2.8e-07 30.3 0.4 1.9 2 0 0 2 2 2 1 G-patch domain G-patch_2 PF12656.7 EGD98264.1 - 0.043 13.9 0.4 0.043 13.9 0.4 3.9 3 1 1 4 4 4 0 G-patch domain SLT_2 PF13406.6 EGD98264.1 - 0.066 12.4 0.1 0.17 11.1 0.1 1.6 1 1 0 1 1 1 0 Transglycosylase SLT domain UBD PF16455.5 EGD98265.1 - 5.4e-41 139.1 0.0 8.2e-41 138.5 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-binding domain ubiquitin PF00240.23 EGD98265.1 - 1.8e-05 24.4 0.0 2.8e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family baeRF_family2 PF18844.1 EGD98265.1 - 0.0031 17.6 1.6 0.0074 16.4 1.6 1.6 1 0 0 1 1 1 1 Bacterial archaeo-eukaryotic release factor family 2 Rad60-SLD PF11976.8 EGD98265.1 - 0.0096 15.7 0.0 0.016 15.0 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like baeRF_family10 PF18854.1 EGD98265.1 - 0.0098 16.1 1.2 0.012 15.9 0.1 1.7 2 0 0 2 2 2 1 Bacterial archaeo-eukaryotic release factor family 10 Nop52 PF05997.12 EGD98266.1 - 4.3e-55 186.9 1.8 6.5e-54 183.0 1.8 2.1 1 1 0 1 1 1 1 Nucleolar protein,Nop52 TAN PF11640.8 EGD98266.1 - 0.023 14.8 0.0 0.045 13.9 0.0 1.6 1 0 0 1 1 1 0 Telomere-length maintenance and DNA damage repair NOT2_3_5 PF04153.18 EGD98266.1 - 0.064 13.4 0.0 0.12 12.5 0.0 1.5 1 0 0 1 1 1 0 NOT2 / NOT3 / NOT5 family SET PF00856.28 EGD98267.1 - 1.2e-17 64.9 0.1 3.3e-17 63.4 0.1 1.8 1 1 0 1 1 1 1 SET domain Pre-SET PF05033.16 EGD98267.1 - 7.7e-11 42.6 3.3 7.7e-11 42.6 3.3 2.3 3 0 0 3 3 3 1 Pre-SET motif Ion_trans PF00520.31 EGD98270.1 - 2.8e-126 419.7 88.0 5.4e-40 137.2 7.5 4.6 4 1 0 4 4 4 4 Ion transport protein GPHH PF16905.5 EGD98270.1 - 0.0087 15.8 0.0 0.02 14.6 0.0 1.7 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated EF-hand_1 PF00036.32 EGD98270.1 - 0.0099 15.4 0.0 0.039 13.5 0.0 2.0 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.6 EGD98270.1 - 0.03 14.3 0.0 0.27 11.3 0.0 2.6 2 0 0 2 2 2 0 EF-hand domain EF-hand_7 PF13499.6 EGD98270.1 - 0.034 14.6 0.0 0.41 11.1 0.0 2.7 2 0 0 2 2 2 0 EF-hand domain pair FUN14 PF04930.15 EGD98270.1 - 0.076 13.4 0.3 25 5.4 0.0 2.8 2 0 0 2 2 2 0 FUN14 family Proteasom_Rpn13 PF04683.13 EGD98271.1 - 7.9e-26 90.4 0.0 1.3e-25 89.8 0.0 1.3 1 0 0 1 1 1 1 Proteasome complex subunit Rpn13 ubiquitin receptor RPN13_C PF16550.5 EGD98271.1 - 2.5e-13 50.2 1.8 1.6e-12 47.6 2.6 1.8 2 0 0 2 2 2 1 UCH-binding domain Ribosomal_L6e PF01159.19 EGD98272.1 - 5.4e-37 126.7 0.6 7.2e-37 126.3 0.0 1.4 2 0 0 2 2 2 1 Ribosomal protein L6e FA_hydroxylase PF04116.13 EGD98273.1 - 1.2e-16 61.3 13.8 1.2e-16 61.3 13.8 1.9 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily adh_short PF00106.25 EGD98274.1 - 1.8e-23 83.1 0.0 2.4e-23 82.6 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EGD98274.1 - 1.9e-10 40.7 0.0 3.2e-10 40.0 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EGD98274.1 - 2.4e-10 40.6 0.1 2.2e-09 37.5 0.1 2.0 1 1 0 1 1 1 1 KR domain THF_DHG_CYH_C PF02882.19 EGD98274.1 - 0.0065 15.8 0.0 0.013 14.9 0.0 1.4 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain GDP_Man_Dehyd PF16363.5 EGD98274.1 - 0.0079 15.6 0.0 0.015 14.7 0.0 1.5 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 EGD98274.1 - 0.014 14.9 0.0 0.024 14.1 0.0 1.5 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family NAD_binding_7 PF13241.6 EGD98274.1 - 0.022 15.2 0.0 0.04 14.4 0.0 1.4 1 0 0 1 1 1 0 Putative NAD(P)-binding Shikimate_DH PF01488.20 EGD98274.1 - 0.027 14.5 0.0 0.093 12.8 0.1 1.8 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase Sacchrp_dh_NADP PF03435.18 EGD98274.1 - 0.038 14.2 0.1 0.066 13.5 0.1 1.3 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Polysacc_synt_2 PF02719.15 EGD98274.1 - 0.14 11.3 0.2 0.91 8.6 0.0 2.0 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein Sas10 PF09368.10 EGD98275.1 - 8.5e-29 99.8 7.6 8.5e-29 99.8 7.6 3.5 4 1 1 5 5 5 1 Sas10 C-terminal domain Sas10_Utp3 PF04000.15 EGD98275.1 - 4.9e-12 46.3 0.1 3e-11 43.8 0.0 2.5 2 0 0 2 2 2 1 Sas10/Utp3/C1D family MutS_V PF00488.21 EGD98276.1 - 1.2e-48 165.7 0.0 2.1e-48 164.8 0.0 1.4 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 EGD98276.1 - 2.4e-19 70.3 0.6 1.3e-18 67.9 0.0 2.3 2 1 0 2 2 2 1 MutS domain III MutS_IV PF05190.18 EGD98276.1 - 0.0057 17.0 0.0 0.019 15.3 0.0 1.9 1 0 0 1 1 1 1 MutS family domain IV Beta_propel PF09826.9 EGD98276.1 - 0.054 12.3 0.0 0.094 11.6 0.0 1.3 1 0 0 1 1 1 0 Beta propeller domain AAA PF00004.29 EGD98276.1 - 0.12 12.8 0.0 0.33 11.4 0.0 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_2 PF07724.14 EGD98277.1 - 4.8e-46 157.0 0.0 1.8e-44 151.9 0.0 2.4 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_lid_9 PF17871.1 EGD98277.1 - 2.8e-35 120.3 1.8 2.8e-35 120.3 1.8 2.5 1 1 1 2 2 2 1 AAA lid domain ClpB_D2-small PF10431.9 EGD98277.1 - 8.1e-27 93.1 0.1 3.2e-26 91.2 0.1 2.1 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA PF00004.29 EGD98277.1 - 1.9e-17 63.9 0.0 8.4e-09 35.9 0.0 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 EGD98277.1 - 1.5e-12 47.7 0.1 1.7e-07 31.3 0.0 2.9 3 0 0 3 3 2 2 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EGD98277.1 - 2.8e-08 34.3 10.0 0.00019 21.9 0.1 4.3 3 2 1 4 4 4 2 AAA ATPase domain Sigma54_activat PF00158.26 EGD98277.1 - 4.6e-08 32.9 0.3 0.00022 21.0 0.0 2.4 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_22 PF13401.6 EGD98277.1 - 1.6e-06 28.4 2.8 0.022 15.0 0.0 3.8 3 2 0 3 3 3 2 AAA domain IstB_IS21 PF01695.17 EGD98277.1 - 7.4e-06 25.8 0.0 0.058 13.1 0.0 3.2 3 0 0 3 3 3 2 IstB-like ATP binding protein TniB PF05621.11 EGD98277.1 - 3.3e-05 23.4 0.1 0.029 13.8 0.0 3.6 3 1 0 3 3 2 1 Bacterial TniB protein AAA_7 PF12775.7 EGD98277.1 - 3.9e-05 23.3 0.0 0.067 12.7 0.0 2.4 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA_14 PF13173.6 EGD98277.1 - 4.8e-05 23.4 0.2 0.17 11.9 0.0 2.8 3 0 0 3 3 2 2 AAA domain NACHT PF05729.12 EGD98277.1 - 6.9e-05 22.8 0.3 0.2 11.6 0.0 2.8 3 0 0 3 3 2 2 NACHT domain AAA_28 PF13521.6 EGD98277.1 - 0.00016 21.9 1.5 0.032 14.5 0.0 3.4 3 1 1 4 4 3 1 AAA domain AAA_18 PF13238.6 EGD98277.1 - 0.00037 21.1 0.1 1.5 9.3 0.0 2.9 2 0 0 2 2 2 2 AAA domain ATPase_2 PF01637.18 EGD98277.1 - 0.00056 19.9 5.6 0.96 9.3 0.1 4.2 3 2 0 3 3 3 1 ATPase domain predominantly from Archaea SRP54 PF00448.22 EGD98277.1 - 0.00098 18.8 0.1 0.16 11.5 0.0 2.5 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain AAA_24 PF13479.6 EGD98277.1 - 0.0011 18.7 0.0 0.64 9.7 0.0 2.4 2 0 0 2 2 2 1 AAA domain Mg_chelatase PF01078.21 EGD98277.1 - 0.0035 16.8 0.2 1.9 7.8 0.1 3.0 2 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI ResIII PF04851.15 EGD98277.1 - 0.0045 17.0 0.0 7.3 6.6 0.0 3.1 3 0 0 3 3 3 0 Type III restriction enzyme, res subunit RNA_helicase PF00910.22 EGD98277.1 - 0.0046 17.3 0.1 2 8.8 0.0 2.8 2 1 0 2 2 2 1 RNA helicase AAA_19 PF13245.6 EGD98277.1 - 0.0054 17.1 0.9 0.17 12.2 0.1 2.9 2 1 0 2 2 2 1 AAA domain ABC_tran PF00005.27 EGD98277.1 - 0.0088 16.6 1.0 0.68 10.4 0.0 3.0 3 0 0 3 3 3 1 ABC transporter AAA_33 PF13671.6 EGD98277.1 - 0.0097 16.1 0.1 3.9 7.6 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.6 EGD98277.1 - 0.01 15.4 0.3 0.19 11.3 0.0 2.8 2 0 0 2 2 2 0 AAA domain RsgA_GTPase PF03193.16 EGD98277.1 - 0.012 15.5 1.1 1.5 8.7 0.0 2.8 3 0 0 3 3 2 0 RsgA GTPase PduV-EutP PF10662.9 EGD98277.1 - 0.012 15.3 0.0 0.49 10.1 0.0 2.6 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation TsaE PF02367.17 EGD98277.1 - 0.015 15.3 1.2 6.4 6.8 0.0 2.9 3 0 0 3 3 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE TrwB_AAD_bind PF10412.9 EGD98277.1 - 0.016 14.1 0.1 0.49 9.3 0.1 2.4 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain Zeta_toxin PF06414.12 EGD98277.1 - 0.019 14.3 0.0 1.9 7.7 0.0 2.5 2 0 0 2 2 2 0 Zeta toxin Roc PF08477.13 EGD98277.1 - 0.02 15.1 0.1 1.7 8.9 0.0 2.5 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase DUF815 PF05673.13 EGD98277.1 - 0.02 14.0 0.3 0.68 9.0 0.1 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF815) UvrD-helicase PF00580.21 EGD98277.1 - 0.035 13.6 2.3 0.42 10.1 0.1 2.2 2 0 0 2 2 2 0 UvrD/REP helicase N-terminal domain FapA PF03961.13 EGD98277.1 - 0.047 12.3 3.3 0.083 11.5 3.3 1.3 1 0 0 1 1 1 0 Flagellar Assembly Protein A AAA_21 PF13304.6 EGD98277.1 - 0.074 12.9 0.2 1.1 9.0 0.0 2.9 4 0 0 4 4 3 0 AAA domain, putative AbiEii toxin, Type IV TA system ATP_bind_1 PF03029.17 EGD98277.1 - 0.11 12.2 0.1 2.1 8.1 0.0 2.4 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_30 PF13604.6 EGD98277.1 - 0.2 11.4 8.1 0.17 11.6 0.4 3.7 4 1 0 4 4 4 0 AAA domain HisKA_2 PF07568.12 EGD98277.1 - 0.24 11.5 1.4 0.78 9.9 0.8 2.2 2 0 0 2 2 1 0 Histidine kinase DUF4094 PF13334.6 EGD98277.1 - 0.34 11.4 2.3 0.72 10.3 0.6 2.5 3 0 0 3 3 1 0 Domain of unknown function (DUF4094) V_ATPase_I PF01496.19 EGD98277.1 - 0.77 7.6 3.0 1.1 7.1 3.0 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family EF1_GNE PF00736.19 EGD98278.1 - 1e-31 108.9 0.8 1e-31 108.9 0.8 1.5 2 0 0 2 2 2 1 EF-1 guanine nucleotide exchange domain EF-1_beta_acid PF10587.9 EGD98278.1 - 5.8e-07 29.8 1.7 5.8e-07 29.8 1.7 1.9 2 0 0 2 2 2 1 Eukaryotic elongation factor 1 beta central acidic region DUF4604 PF15377.6 EGD98278.1 - 0.04 14.3 1.0 0.055 13.9 1.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) GST_C PF00043.25 EGD98278.1 - 0.079 13.2 0.1 0.27 11.5 0.1 1.9 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain MMgT PF10270.9 EGD98279.1 - 6.8e-33 113.0 0.0 8.2e-33 112.7 0.0 1.1 1 0 0 1 1 1 1 Membrane magnesium transporter UQ_con PF00179.26 EGD98281.1 - 0.062 13.0 0.0 0.13 11.9 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin-conjugating enzyme Plasmodium_Vir PF05795.11 EGD98281.1 - 0.78 9.1 2.4 1.6 8.1 2.4 1.5 1 0 0 1 1 1 0 Plasmodium vivax Vir protein RNB PF00773.19 EGD98282.1 - 2.1e-77 260.6 0.0 6.8e-77 259.0 0.0 1.8 2 0 0 2 2 2 1 RNB domain Dis3l2_C_term PF17877.1 EGD98282.1 - 2.1e-25 88.9 0.0 6.8e-25 87.2 0.0 2.0 1 0 0 1 1 1 1 DIS3-like exonuclease 2 C terminal OB_Dis3 PF17849.1 EGD98282.1 - 1.4e-24 85.9 0.0 3.2e-24 84.7 0.0 1.6 1 0 0 1 1 1 1 Dis3-like cold-shock domain 2 (CSD2) CSD2 PF17876.1 EGD98282.1 - 0.00058 20.0 0.0 0.19 11.9 0.0 2.6 2 0 0 2 2 2 2 Cold shock domain DUF4667 PF15700.5 EGD98282.1 - 0.00071 19.8 3.9 0.00071 19.8 3.9 2.6 3 0 0 3 3 3 1 Domain of unknown function (DUF4667) Rrp44_CSD1 PF17216.3 EGD98282.1 - 0.0014 18.3 0.0 0.0039 16.9 0.0 1.7 1 0 0 1 1 1 1 Rrp44-like cold shock domain TFIIA PF03153.13 EGD98282.1 - 0.0053 16.8 15.2 0.0053 16.8 15.2 3.3 2 1 0 3 3 3 1 Transcription factor IIA, alpha/beta subunit Cytomega_UL84 PF06284.11 EGD98283.1 - 0.056 11.9 0.1 0.056 11.9 0.1 2.1 2 0 0 2 2 2 0 Cytomegalovirus UL84 protein AP3D1 PF06375.11 EGD98283.1 - 0.27 11.5 5.3 0.47 10.7 5.3 1.4 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 GLE1 PF07817.13 EGD98284.1 - 7.3e-33 113.8 0.0 7.3e-33 113.8 0.0 1.6 2 0 0 2 2 2 1 GLE1-like protein AF-4 PF05110.13 EGD98284.1 - 1.8 6.6 33.9 2.3 6.2 33.9 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein DUF4045 PF13254.6 EGD98284.1 - 7.2 6.1 33.5 11 5.6 33.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) DUF3425 PF11905.8 EGD98285.1 - 1.2e-10 41.4 0.1 2.4e-10 40.5 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3425) bZIP_1 PF00170.21 EGD98285.1 - 0.0041 17.2 17.2 0.069 13.3 17.2 2.1 1 1 0 1 1 1 1 bZIP transcription factor PRKG1_interact PF15898.5 EGD98285.1 - 0.0079 17.1 7.4 0.011 16.6 7.4 1.2 1 0 0 1 1 1 1 cGMP-dependent protein kinase interacting domain ZapB PF06005.12 EGD98285.1 - 0.022 15.2 3.5 0.033 14.6 3.0 1.5 1 1 0 1 1 1 0 Cell division protein ZapB DivIC PF04977.15 EGD98285.1 - 0.062 13.1 0.9 0.12 12.2 0.6 1.6 1 1 0 1 1 1 0 Septum formation initiator DUF3696 PF12476.8 EGD98285.1 - 0.1 13.0 0.1 0.26 11.7 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3696) DUF2937 PF11157.8 EGD98285.1 - 0.35 10.6 1.2 0.55 9.9 1.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2937) DUF5094 PF17015.5 EGD98285.1 - 0.57 10.3 3.1 0.82 9.7 3.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5094) TMEM192 PF14802.6 EGD98285.1 - 0.62 9.1 2.4 0.84 8.7 2.4 1.2 1 0 0 1 1 1 0 TMEM192 family GBP_C PF02841.14 EGD98285.1 - 0.69 9.3 5.3 0.95 8.8 5.3 1.1 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain DUF2508 PF10704.9 EGD98286.1 - 0.022 14.9 0.5 0.022 14.9 0.5 4.3 6 0 0 6 6 6 0 Protein of unknown function (DUF2508) PAM2 PF07145.15 EGD98286.1 - 0.75 9.6 10.4 12 5.9 0.1 4.3 4 0 0 4 4 4 0 Ataxin-2 C-terminal region Glyco_hydro_17 PF00332.18 EGD98287.1 - 6.6e-32 111.3 0.0 5.5e-31 108.3 0.0 1.9 1 1 0 1 1 1 1 Glycosyl hydrolases family 17 Myb_DNA-bind_6 PF13921.6 EGD98288.1 - 0.00069 19.8 1.4 0.0082 16.4 0.7 2.4 2 0 0 2 2 2 1 Myb-like DNA-binding domain MADF_DNA_bdg PF10545.9 EGD98288.1 - 0.03 14.6 2.1 0.057 13.7 1.1 2.2 2 1 0 2 2 2 0 Alcohol dehydrogenase transcription factor Myb/SANT-like Myb_DNA-binding PF00249.31 EGD98288.1 - 0.048 13.9 3.4 0.88 9.8 1.8 2.5 2 1 0 2 2 2 0 Myb-like DNA-binding domain GcrA PF07750.11 EGD98288.1 - 0.6 10.5 5.2 0.22 11.9 0.8 2.4 2 1 0 2 2 2 0 GcrA cell cycle regulator FGF-BP1 PF06473.12 EGD98288.1 - 1.1 9.1 10.0 0.061 13.2 2.9 2.0 1 1 1 2 2 2 0 FGF binding protein 1 (FGF-BP1) Totivirus_coat PF05518.11 EGD98288.1 - 3.1 5.8 6.8 4.1 5.3 6.8 1.1 1 0 0 1 1 1 0 Totivirus coat protein PRIMA1 PF16101.5 EGD98288.1 - 3.8 7.6 11.6 3.4 7.7 6.5 2.2 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 EMP24_GP25L PF01105.24 EGD98289.1 - 1.5e-46 158.7 0.1 1.7e-46 158.5 0.1 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Vac_ImportDeg PF09783.9 EGD98289.1 - 0.06 13.1 0.0 0.09 12.6 0.0 1.3 1 0 0 1 1 1 0 Vacuolar import and degradation protein DUF5643 PF18705.1 EGD98289.1 - 0.069 13.1 0.0 0.095 12.7 0.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5643) DUF1408 PF07193.11 EGD98289.1 - 0.13 12.4 0.1 0.21 11.7 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1408) MAP17 PF15807.5 EGD98290.1 - 0.00063 20.0 0.0 0.0012 19.0 0.0 1.4 2 0 0 2 2 2 1 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 GRP PF07172.11 EGD98290.1 - 0.00071 20.2 8.7 0.001 19.7 8.7 1.2 1 0 0 1 1 1 1 Glycine rich protein family PSI PF01437.25 EGD98290.1 - 0.00093 19.7 7.6 0.0018 18.8 7.6 1.5 1 0 0 1 1 1 1 Plexin repeat SARAF PF06682.12 EGD98290.1 - 0.0018 18.0 0.0 0.0021 17.8 0.0 1.1 1 0 0 1 1 1 1 SOCE-associated regulatory factor of calcium homoeostasis TNFR_16_TM PF18422.1 EGD98290.1 - 0.02 14.9 0.0 0.036 14.0 0.0 1.4 1 0 0 1 1 1 0 Tumor necrosis factor receptor member 16 trans-membrane domain TM231 PF10149.9 EGD98290.1 - 0.2 10.9 0.1 0.29 10.4 0.1 1.1 1 0 0 1 1 1 0 Transmembrane protein 231 EphA2_TM PF14575.6 EGD98290.1 - 0.22 12.4 0.0 0.31 11.9 0.0 1.4 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain PSI_integrin PF17205.3 EGD98290.1 - 0.4 10.5 9.8 0.82 9.5 9.8 1.4 1 0 0 1 1 1 0 Integrin plexin domain FeoB_associated PF12669.7 EGD98290.1 - 0.46 10.9 0.0 0.46 10.9 0.0 2.5 2 1 0 2 2 2 0 FeoB-associated Cys-rich membrane protein DUF3237 PF11578.8 EGD98291.1 - 1.8e-38 131.7 0.0 2.1e-38 131.5 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3237) SRP72 PF08492.12 EGD98292.1 - 0.11 12.9 9.7 0.18 12.3 6.3 2.7 2 0 0 2 2 2 0 SRP72 RNA-binding domain Lant_dehydr_C PF14028.6 EGD98292.1 - 0.13 11.7 0.0 0.29 10.6 0.0 1.5 1 0 0 1 1 1 0 Lantibiotic biosynthesis dehydratase C-term Goodbye PF17109.5 EGD98293.1 - 9.6e-30 103.5 0.3 4.7e-29 101.3 0.3 2.3 1 0 0 1 1 1 1 fungal STAND N-terminal Goodbye domain TPR_6 PF13174.6 EGD98293.1 - 0.04 14.6 0.8 5 8.0 0.1 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat PP1_inhibitor PF05361.12 EGD98293.1 - 2.6 8.0 9.2 19 5.3 5.8 3.8 3 1 0 3 3 3 0 PKC-activated protein phosphatase-1 inhibitor SesA PF17107.5 EGD98295.1 - 3.8e-06 27.1 0.0 0.0071 16.5 0.0 2.4 2 0 0 2 2 2 2 N-terminal domain on NACHT_NTPase and P-loop NTPases VIT PF08487.10 EGD98296.1 - 1.4e-30 105.8 0.0 6.1e-30 103.7 0.1 2.1 3 0 0 3 3 3 1 Vault protein inter-alpha-trypsin domain VWA_3 PF13768.6 EGD98296.1 - 7.6e-25 87.7 0.0 1.4e-24 86.8 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VIT_2 PF13757.6 EGD98296.1 - 1.5e-06 28.0 0.0 4.4e-06 26.5 0.0 1.7 2 0 0 2 2 2 1 Vault protein inter-alpha-trypsin domain VWA PF00092.28 EGD98296.1 - 3.1e-06 27.5 0.0 5.2e-06 26.8 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 EGD98296.1 - 0.0017 19.0 0.0 0.0039 17.8 0.0 1.7 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_CoxE PF05762.14 EGD98296.1 - 0.0094 15.4 0.0 0.0094 15.4 0.0 1.9 2 0 0 2 2 2 1 VWA domain containing CoxE-like protein DUF2201 PF09967.9 EGD98296.1 - 0.12 12.5 0.1 0.35 11.0 0.0 1.8 2 0 0 2 2 2 0 VWA-like domain (DUF2201) LANC_like PF05147.13 EGD98297.1 - 1.9e-21 76.0 0.0 3.5e-19 68.6 0.0 2.3 2 1 0 2 2 2 2 Lanthionine synthetase C-like protein Haem_oxygenas_2 PF14518.6 EGD98297.1 - 0.097 12.4 0.0 0.2 11.4 0.0 1.5 1 0 0 1 1 1 0 Iron-containing redox enzyme CBF PF03914.17 EGD98298.1 - 1.3e-54 184.8 0.1 1.3e-54 184.8 0.1 2.9 5 0 0 5 5 5 1 CBF/Mak21 family Prok-E2_C PF14459.6 EGD98298.1 - 0.092 12.9 0.0 0.2 11.8 0.0 1.5 1 0 0 1 1 1 0 Prokaryotic E2 family C Cnd1 PF12717.7 EGD98298.1 - 0.099 12.7 0.3 1.6 8.8 0.0 2.3 2 0 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1 tRNA-synt_2b PF00587.25 EGD98299.1 - 1.6e-29 103.1 0.0 6e-29 101.3 0.0 1.9 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 EGD98299.1 - 3.5e-09 36.7 0.0 9.2e-09 35.4 0.0 1.8 1 0 0 1 1 1 1 Anticodon binding domain zf-ribbon_3 PF13248.6 EGD98299.1 - 0.072 12.5 0.4 0.072 12.5 0.4 2.1 2 0 0 2 2 2 0 zinc-ribbon domain Prefoldin PF02996.17 EGD98300.1 - 8.6e-23 80.5 0.1 1.1e-22 80.2 0.1 1.1 1 0 0 1 1 1 1 Prefoldin subunit KH_1 PF00013.29 EGD98301.1 - 0.0046 16.8 0.0 0.59 10.0 0.0 2.5 2 0 0 2 2 2 2 KH domain CHCH PF06747.13 EGD98302.1 - 2.4e-06 27.5 11.6 6.4e-05 23.0 5.7 2.4 2 0 0 2 2 2 2 CHCH domain Cmc1 PF08583.10 EGD98302.1 - 0.036 14.1 8.1 2.7 8.1 0.0 3.0 2 1 1 3 3 3 0 Cytochrome c oxidase biogenesis protein Cmc1 like CX9C PF16860.5 EGD98302.1 - 0.16 12.0 7.7 1 9.4 4.5 2.2 2 0 0 2 2 2 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, NDUF_B7 PF05676.13 EGD98302.1 - 1.1 9.0 5.5 7.8 6.3 1.6 2.3 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) CAP PF00188.26 EGD98303.1 - 3.9e-14 53.6 6.9 5.9e-14 53.0 6.9 1.2 1 0 0 1 1 1 1 Cysteine-rich secretory protein family PPTA PF01239.22 EGD98303.1 - 0.3 10.9 1.4 0.64 9.8 1.4 1.5 1 0 0 1 1 1 0 Protein prenyltransferase alpha subunit repeat Thioredox_DsbH PF03190.15 EGD98304.1 - 5.8e-70 234.5 0.0 1.4e-69 233.3 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function, DUF255 Thioredoxin_7 PF13899.6 EGD98304.1 - 2.9e-06 27.4 0.0 1.2e-05 25.4 0.0 2.1 2 0 0 2 2 2 1 Thioredoxin-like DUF2384 PF09722.10 EGD98304.1 - 0.11 12.5 0.0 6.3 6.9 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2384) WD40 PF00400.32 EGD98305.1 - 1.6e-12 47.7 16.2 0.0078 17.0 0.0 6.2 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EGD98305.1 - 0.01 16.1 0.1 6.8 7.1 0.0 3.5 2 2 1 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain DUF1513 PF07433.11 EGD98305.1 - 0.025 13.7 0.1 0.22 10.6 0.0 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF1513) Nucleoporin_N PF08801.11 EGD98305.1 - 0.068 11.9 0.1 0.22 10.3 0.0 1.8 2 1 0 2 2 2 0 Nup133 N terminal like Nup160 PF11715.8 EGD98305.1 - 0.091 11.4 0.0 0.13 10.8 0.0 1.3 1 0 0 1 1 1 0 Nucleoporin Nup120/160 LSM14 PF12701.7 EGD98306.1 - 3.4e-26 91.1 0.0 6.1e-26 90.3 0.0 1.4 1 0 0 1 1 1 1 Scd6-like Sm domain FDF PF09532.10 EGD98306.1 - 1.6e-18 67.4 2.6 1.6e-18 67.4 2.6 3.4 3 0 0 3 3 3 1 FDF domain SM-ATX PF14438.6 EGD98306.1 - 0.00026 21.1 0.1 0.00076 19.6 0.0 1.8 2 0 0 2 2 2 1 Ataxin 2 SM domain TFIIA PF03153.13 EGD98306.1 - 0.35 10.8 43.1 0.022 14.8 32.8 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit ACBP PF00887.19 EGD98307.1 - 2.5e-22 78.9 0.0 2.5e-22 78.9 0.0 2.4 2 1 0 2 2 2 1 Acyl CoA binding protein DNA_repr_REX1B PF14966.6 EGD98307.1 - 0.1 13.3 0.4 0.23 12.2 0.4 1.5 1 0 0 1 1 1 0 DNA repair REX1-B Sporozoite_P67 PF05642.11 EGD98307.1 - 0.16 10.0 2.2 0.2 9.7 2.2 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen TraP PF07296.11 EGD98307.1 - 0.25 10.5 0.9 0.39 9.9 0.9 1.3 1 0 0 1 1 1 0 TraP protein PilJ PF13675.6 EGD98307.1 - 0.4 10.7 3.4 1.2 9.2 1.8 2.2 2 0 0 2 2 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term DUF1754 PF08555.10 EGD98307.1 - 1.6 9.6 10.2 2.3 9.0 7.2 2.2 2 0 0 2 2 2 0 Eukaryotic family of unknown function (DUF1754) DNA_pol_phi PF04931.13 EGD98307.1 - 2.6 6.0 6.1 4.5 5.3 6.0 1.4 2 0 0 2 2 2 0 DNA polymerase phi NOA36 PF06524.12 EGD98307.1 - 4.6 6.5 7.1 7 5.9 7.1 1.2 1 0 0 1 1 1 0 NOA36 protein Glyco_transf_15 PF01793.16 EGD98308.1 - 8.5e-116 386.7 7.7 1e-115 386.5 7.7 1.0 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase GCP_N_terminal PF17681.1 EGD98309.1 - 1.6e-29 103.5 2.3 2e-29 103.2 0.6 1.9 2 0 0 2 2 2 1 Gamma tubulin complex component N-terminal GCP_C_terminal PF04130.13 EGD98309.1 - 6.8e-24 84.9 1.6 6.8e-24 84.9 1.6 2.3 2 0 0 2 2 2 1 Gamma tubulin complex component C-terminal GCP5-Mod21 PF14609.6 EGD98309.1 - 0.00013 20.5 1.4 0.00034 19.1 0.5 2.1 2 1 0 2 2 2 1 gamma-Tubulin ring complex non-core subunit mod21 GATase_5 PF13507.6 EGD98310.1 - 2.6e-97 325.0 0.0 4.3e-97 324.3 0.0 1.4 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain AIRS_C PF02769.22 EGD98310.1 - 2.3e-39 135.0 0.6 1.1e-24 87.4 0.2 2.5 2 0 0 2 2 2 2 AIR synthase related protein, C-terminal domain FGAR-AT_N PF18076.1 EGD98310.1 - 4.2e-32 110.5 0.0 7.5e-32 109.7 0.0 1.4 1 0 0 1 1 1 1 Formylglycinamide ribonucleotide amidotransferase N-terminal FGAR-AT_linker PF18072.1 EGD98310.1 - 3.7e-21 75.4 0.0 8.7e-21 74.2 0.0 1.7 1 0 0 1 1 1 1 Formylglycinamide ribonucleotide amidotransferase linker domain AIRS PF00586.24 EGD98310.1 - 0.1 13.3 0.7 0.85 10.3 0.0 2.7 3 0 0 3 3 3 0 AIR synthase related protein, N-terminal domain MFS_1 PF07690.16 EGD98311.1 - 1.3e-44 152.6 28.6 1.3e-44 152.6 28.6 1.7 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EGD98311.1 - 4.4e-08 32.4 26.9 9.9e-08 31.3 26.9 1.5 1 1 0 1 1 1 1 Sugar (and other) transporter TRI12 PF06609.13 EGD98311.1 - 1.2e-06 27.3 3.3 2e-06 26.5 3.3 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_4 PF06779.14 EGD98311.1 - 1.8e-05 24.2 0.9 1.8e-05 24.2 0.9 2.3 3 0 0 3 3 3 1 Uncharacterised MFS-type transporter YbfB DUF4271 PF14093.6 EGD98311.1 - 0.065 13.1 0.1 0.065 13.1 0.1 3.8 3 1 0 4 4 4 0 Domain of unknown function (DUF4271) DUF4064 PF13273.6 EGD98311.1 - 5.7 7.3 11.2 3 8.2 0.1 4.5 4 2 0 4 4 4 0 Protein of unknown function (DUF4064) zf-C3H1 PF10650.9 EGD98312.1 - 1.1e-09 37.8 1.0 1.9e-09 37.0 1.0 1.4 1 0 0 1 1 1 1 Putative zinc-finger domain Myosin_head PF00063.21 EGD98313.1 - 1.5e-264 879.3 1.5 1.8e-264 879.1 0.0 1.9 2 0 0 2 2 2 1 Myosin head (motor domain) Myosin_tail_1 PF01576.19 EGD98313.1 - 1.4e-15 56.3 269.2 1.1e-09 36.8 119.0 6.9 2 2 1 3 3 3 2 Myosin tail Myosin_N PF02736.19 EGD98313.1 - 7.7e-11 41.6 0.1 1.8e-10 40.4 0.1 1.7 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain ADIP PF11559.8 EGD98313.1 - 0.00068 19.7 12.0 0.00068 19.7 12.0 17.7 4 3 13 19 19 19 3 Afadin- and alpha -actinin-Binding DUF1292 PF06949.11 EGD98313.1 - 0.04 14.9 0.1 0.2 12.6 0.1 2.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1292) AAA_22 PF13401.6 EGD98313.1 - 0.51 10.6 0.0 0.51 10.6 0.0 5.4 4 2 2 6 6 6 0 AAA domain Isy1 PF06246.12 EGD98314.1 - 1.4e-87 293.5 0.1 1.6e-87 293.3 0.1 1.0 1 0 0 1 1 1 1 Isy1-like splicing family MMR_HSR1 PF01926.23 EGD98315.1 - 2.2e-12 47.1 0.0 4.5e-12 46.1 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EGD98315.1 - 4.1e-07 30.1 0.0 9e-07 28.9 0.0 1.5 1 1 0 1 1 1 1 RsgA GTPase FeoB_N PF02421.18 EGD98315.1 - 0.00065 19.3 0.3 0.0016 18.0 0.3 1.7 1 1 0 1 1 1 1 Ferrous iron transport protein B AAA_18 PF13238.6 EGD98315.1 - 0.011 16.3 0.0 0.021 15.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain GTP_EFTU PF00009.27 EGD98315.1 - 0.022 14.3 0.0 0.055 13.0 0.0 1.6 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain NB-ARC PF00931.22 EGD98315.1 - 0.044 13.0 0.0 2.1 7.5 0.0 2.2 2 0 0 2 2 2 0 NB-ARC domain MeaB PF03308.16 EGD98315.1 - 0.06 12.3 0.0 0.096 11.6 0.0 1.3 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Arf PF00025.21 EGD98315.1 - 0.1 12.1 0.0 0.19 11.1 0.0 1.4 1 0 0 1 1 1 0 ADP-ribosylation factor family TniB PF05621.11 EGD98315.1 - 0.1 12.0 0.0 0.23 10.9 0.0 1.5 1 0 0 1 1 1 0 Bacterial TniB protein NTPase_1 PF03266.15 EGD98315.1 - 0.1 12.5 0.1 0.18 11.7 0.1 1.4 1 0 0 1 1 1 0 NTPase Septin PF00735.18 EGD98315.1 - 0.11 11.7 0.0 0.27 10.5 0.0 1.6 2 0 0 2 2 2 0 Septin Roc PF08477.13 EGD98315.1 - 0.15 12.3 0.0 0.26 11.5 0.0 1.4 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase HCO3_cotransp PF00955.21 EGD98316.1 - 2.7e-67 227.8 14.1 1.5e-38 132.9 0.5 2.1 1 1 1 2 2 2 2 HCO3- transporter family PI3Ka PF00613.20 EGD98317.1 - 7.9e-59 198.2 0.1 1.3e-58 197.5 0.1 1.2 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3_PI4_kinase PF00454.27 EGD98317.1 - 1e-45 156.5 0.0 1.4e-30 107.0 0.0 2.5 1 1 1 2 2 2 2 Phosphatidylinositol 3- and 4-kinase PI3K_C2 PF00792.24 EGD98317.1 - 1.9e-32 112.1 0.0 3.2e-32 111.3 0.0 1.4 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 Nse4_C PF08743.10 EGD98318.1 - 1.2e-31 108.8 0.0 3.5e-31 107.3 0.0 1.8 1 0 0 1 1 1 1 Nse4 C-terminal Nse4-Nse3_bdg PF15412.6 EGD98318.1 - 2.2e-15 56.5 0.1 6.7e-15 54.9 0.1 1.9 1 0 0 1 1 1 1 Binding domain of Nse4/EID3 to Nse3-MAGE DUF4336 PF14234.6 EGD98319.1 - 6.3e-13 48.6 0.1 8.5e-13 48.2 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4336) Tox-GHH PF15636.6 EGD98319.1 - 0.024 14.6 0.2 5.3 7.1 0.1 2.2 2 0 0 2 2 2 0 GHH signature containing HNH/Endo VII superfamily nuclease toxin MARVEL PF01284.23 EGD98320.1 - 4.3e-10 39.8 11.2 6.8e-10 39.1 11.2 1.4 1 1 0 1 1 1 1 Membrane-associating domain ABC2_membrane_2 PF12679.7 EGD98320.1 - 0.41 9.9 4.1 0.32 10.2 2.8 1.4 2 0 0 2 2 2 0 ABC-2 family transporter protein ThiF PF00899.21 EGD98322.1 - 2.3e-41 141.8 0.0 3.4e-41 141.2 0.0 1.2 1 0 0 1 1 1 1 ThiF family Sacchrp_dh_NADP PF03435.18 EGD98322.1 - 0.00096 19.4 1.4 0.016 15.4 1.4 2.3 1 1 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain TrkA_N PF02254.18 EGD98322.1 - 0.0056 16.9 0.1 0.013 15.7 0.1 1.7 1 0 0 1 1 1 1 TrkA-N domain UDPG_MGDP_dh_N PF03721.14 EGD98322.1 - 0.032 13.8 0.1 0.09 12.3 0.1 1.8 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain ApbA PF02558.16 EGD98322.1 - 0.083 12.5 0.0 0.14 11.8 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Melibiase_2 PF16499.5 EGD98322.1 - 0.097 11.8 0.0 0.15 11.2 0.0 1.2 1 0 0 1 1 1 0 Alpha galactosidase A GIDA PF01134.22 EGD98322.1 - 0.24 10.4 0.4 0.44 9.6 0.4 1.4 1 0 0 1 1 1 0 Glucose inhibited division protein A Clathrin PF00637.20 EGD98323.1 - 7.7e-19 68.0 0.0 3.4e-18 65.9 0.0 2.0 2 0 0 2 2 2 1 Region in Clathrin and VPS WD40_like PF17005.5 EGD98323.1 - 0.014 14.7 0.0 0.022 14.1 0.0 1.2 1 0 0 1 1 1 0 WD40-like domain zf-RING_5 PF14634.6 EGD98323.1 - 0.017 15.1 0.3 0.017 15.1 0.3 1.9 2 0 0 2 2 2 0 zinc-RING finger domain Vps39_1 PF10366.9 EGD98323.1 - 0.13 12.5 0.1 0.46 10.8 0.0 1.9 2 0 0 2 2 2 0 Vacuolar sorting protein 39 domain 1 Cwf_Cwc_15 PF04889.12 EGD98323.1 - 3.9 7.1 13.6 8.8 6.0 13.6 1.5 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DUF155 PF02582.14 EGD98324.1 - 8.2e-51 172.6 0.0 1.1e-50 172.1 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 zf-H2C2_2 PF13465.6 EGD98325.1 - 2e-09 37.5 5.1 0.0013 19.1 0.1 3.0 2 0 0 2 2 2 2 Zinc-finger double domain zf-C2H2 PF00096.26 EGD98325.1 - 3e-07 30.5 17.1 0.00099 19.4 4.7 3.8 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EGD98325.1 - 6.1e-06 26.6 14.7 0.0071 17.1 3.4 4.1 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_6 PF13912.6 EGD98325.1 - 0.05 13.6 7.1 1.3 9.1 2.5 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger zf-H2C2_5 PF13909.6 EGD98325.1 - 0.16 11.7 7.2 0.085 12.6 2.7 2.7 2 0 0 2 2 2 0 C2H2-type zinc-finger domain zf-C2HE PF16278.5 EGD98325.1 - 0.17 12.3 1.4 0.45 11.0 1.4 1.7 1 0 0 1 1 1 0 C2HE / C2H2 / C2HC zinc-binding finger zf-BED PF02892.15 EGD98325.1 - 1.3 9.1 6.8 1.7 8.8 3.7 2.5 1 1 1 2 2 2 0 BED zinc finger zf-LYAR PF08790.11 EGD98325.1 - 7.6 6.5 9.0 30 4.6 0.0 3.7 3 0 0 3 3 3 0 LYAR-type C2HC zinc finger zf-C2H2_jaz PF12171.8 EGD98325.1 - 9 6.7 9.3 0.61 10.4 2.2 2.6 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding ubiquitin PF00240.23 EGD98326.1 - 5.7e-34 115.7 0.7 9.7e-34 115.0 0.7 1.4 1 0 0 1 1 1 1 Ubiquitin family Ribosomal_S27 PF01599.19 EGD98326.1 - 1.5e-26 92.3 1.9 1.5e-26 92.3 1.9 1.9 2 0 0 2 2 2 1 Ribosomal protein S27a Rad60-SLD PF11976.8 EGD98326.1 - 4.1e-16 58.6 0.8 7.4e-16 57.7 0.8 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EGD98326.1 - 2.5e-05 24.7 0.2 0.00013 22.4 0.2 2.0 1 1 0 1 1 1 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 EGD98326.1 - 0.00085 19.4 0.6 0.0019 18.3 0.6 1.6 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like TBK1_ULD PF18396.1 EGD98326.1 - 0.0061 16.5 0.0 0.009 15.9 0.0 1.3 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_5 PF18037.1 EGD98326.1 - 0.0081 16.5 0.9 0.013 15.8 0.1 1.7 1 1 1 2 2 2 1 Ubiquitin-like domain DUF2407 PF10302.9 EGD98326.1 - 0.0086 16.6 0.9 0.012 16.1 0.9 1.2 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain IBR PF01485.21 EGD98326.1 - 0.013 15.7 0.3 0.021 15.0 0.3 1.4 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain Ubiquitin_4 PF18036.1 EGD98326.1 - 0.023 14.7 1.1 6.1 7.0 0.2 2.4 2 0 0 2 2 2 0 Ubiquitin-like domain Glyco_hydro_18 PF00704.28 EGD98327.1 - 1.1e-86 291.4 1.2 1.3e-86 291.2 1.2 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 PTR2 PF00854.21 EGD98328.1 - 5.1e-92 308.7 8.1 9.5e-92 307.8 8.1 1.4 1 1 0 1 1 1 1 POT family Rbx_binding PF18113.1 EGD98329.1 - 0.17 11.7 0.0 0.38 10.6 0.0 1.5 1 0 0 1 1 1 0 Rubredoxin binding C-terminal domain Proteasome PF00227.26 EGD98330.1 - 3.9e-48 163.5 0.0 5.5e-48 163.0 0.0 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EGD98330.1 - 4.6e-13 48.6 0.3 8.3e-13 47.8 0.3 1.5 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature SCP2 PF02036.17 EGD98330.1 - 0.041 14.4 0.0 0.092 13.2 0.0 1.6 1 0 0 1 1 1 0 SCP-2 sterol transfer family Amidase_5 PF05382.13 EGD98330.1 - 0.057 13.3 0.0 4.1 7.3 0.0 2.3 2 0 0 2 2 2 0 Bacteriophage peptidoglycan hydrolase DUF2373 PF10180.9 EGD98331.1 - 1.9e-21 75.7 0.1 3.6e-21 74.8 0.1 1.5 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2373) GCP_C_terminal PF04130.13 EGD98332.1 - 1.3e-101 340.2 0.0 2.6e-101 339.2 0.0 1.5 1 0 0 1 1 1 1 Gamma tubulin complex component C-terminal GCP_N_terminal PF17681.1 EGD98332.1 - 1.7e-79 267.6 0.1 1.7e-78 264.4 0.0 2.2 2 0 0 2 2 2 1 Gamma tubulin complex component N-terminal EGF_Tenascin PF18720.1 EGD98333.1 - 2.2 8.4 52.6 0.79 9.8 6.3 4.8 4 0 0 4 4 4 0 Tenascin EGF domain FliC PF12445.8 EGD98333.1 - 7.3 6.9 7.4 17 5.8 3.1 2.9 1 1 2 3 3 3 0 Flagellin protein Pkinase PF00069.25 EGD98334.1 - 1.4e-62 211.5 0.0 2e-62 210.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD98334.1 - 5.4e-43 147.2 0.0 8.3e-43 146.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EGD98334.1 - 2.4e-10 40.2 0.0 7.2e-07 28.8 0.0 2.2 2 0 0 2 2 2 2 Kinase-like Pkinase_fungal PF17667.1 EGD98334.1 - 0.003 16.4 0.0 0.0074 15.1 0.0 1.6 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EGD98334.1 - 0.003 16.9 0.0 0.0059 16.0 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RepL PF05732.11 EGD98334.1 - 0.058 12.8 0.1 0.11 12.0 0.1 1.3 1 0 0 1 1 1 0 Firmicute plasmid replication protein (RepL) APH PF01636.23 EGD98334.1 - 0.074 13.0 0.0 0.15 11.9 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family Rad9 PF04139.13 EGD98335.1 - 2.3e-50 171.4 0.0 3e-50 171.0 0.0 1.1 1 0 0 1 1 1 1 Rad9 Sushi_2 PF09014.10 EGD98335.1 - 0.063 13.2 0.2 0.22 11.4 0.1 1.9 2 0 0 2 2 2 0 Beta-2-glycoprotein-1 fifth domain RCC1 PF00415.18 EGD98336.1 - 2.8e-33 114.3 7.3 8.1e-07 29.6 0.0 6.4 6 0 0 6 6 6 6 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EGD98336.1 - 3.8e-14 52.0 22.1 3.9e-05 23.3 0.3 5.9 6 0 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat Mannitol_dh_C PF08125.13 EGD98337.1 - 8.3e-41 140.1 0.0 1.2e-40 139.5 0.0 1.3 1 0 0 1 1 1 1 Mannitol dehydrogenase C-terminal domain Mannitol_dh PF01232.23 EGD98337.1 - 1.9e-07 31.4 2.0 2.4e-07 31.0 0.8 1.8 2 0 0 2 2 2 1 Mannitol dehydrogenase Rossmann domain Sec34 PF04136.15 EGD98339.1 - 3.3e-49 166.6 0.1 8.4e-49 165.3 0.1 1.7 1 0 0 1 1 1 1 Sec34-like family Pkinase PF00069.25 EGD98342.1 - 1.6e-13 50.7 0.0 3.5e-12 46.2 0.0 2.2 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD98342.1 - 4.8e-10 39.1 0.0 1.9e-09 37.2 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase Aldose_epim PF01263.20 EGD98344.1 - 2.4e-48 165.0 0.2 3.1e-48 164.6 0.2 1.1 1 0 0 1 1 1 1 Aldose 1-epimerase Actin PF00022.19 EGD98346.1 - 6.2e-22 77.8 0.0 8e-19 67.5 0.0 3.0 2 1 0 2 2 2 2 Actin MreB_Mbl PF06723.13 EGD98346.1 - 0.11 11.3 0.0 0.36 9.6 0.0 1.7 2 0 0 2 2 2 0 MreB/Mbl protein XPG_I PF00867.18 EGD98347.1 - 5.3e-22 78.0 0.1 1.2e-21 76.8 0.1 1.7 1 0 0 1 1 1 1 XPG I-region GEN1_C PF18380.1 EGD98347.1 - 5.5e-16 59.4 0.2 5.5e-16 59.4 0.2 2.4 1 1 1 2 2 2 1 Holliday junction resolvase Gen1 C-terminal domain XPG_N PF00752.17 EGD98347.1 - 9e-08 32.5 0.0 2.1e-07 31.3 0.0 1.7 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I_2 PF12813.7 EGD98347.1 - 0.024 14.1 0.0 0.043 13.3 0.0 1.3 1 0 0 1 1 1 0 XPG domain containing DEAD PF00270.29 EGD98349.1 - 4.4e-37 127.5 0.0 2.1e-36 125.3 0.0 2.0 1 1 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EGD98349.1 - 2e-21 76.4 0.0 1.4e-20 73.7 0.0 2.4 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 EGD98349.1 - 7.1e-20 71.0 0.0 1.3e-19 70.2 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 EGD98349.1 - 0.011 15.8 0.0 0.033 14.2 0.0 1.7 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit AAA_22 PF13401.6 EGD98349.1 - 0.096 13.0 1.4 0.51 10.6 0.2 2.5 2 1 0 2 2 2 0 AAA domain Ribosomal_S15 PF00312.22 EGD98351.1 - 8.8e-25 86.7 1.3 2.9e-24 85.1 0.1 2.1 2 0 0 2 2 2 1 Ribosomal protein S15 Hanta_nucleocap PF00846.18 EGD98351.1 - 0.0013 17.3 0.8 0.0017 16.9 0.2 1.5 2 0 0 2 2 2 1 Hantavirus nucleocapsid protein Ribosomal_S2 PF00318.20 EGD98352.1 - 5.1e-26 91.2 0.1 3e-14 52.8 0.1 2.1 1 1 1 2 2 2 2 Ribosomal protein S2 40S_SA_C PF16122.5 EGD98352.1 - 3.1e-05 25.3 20.6 5.8e-05 24.4 20.6 1.5 1 0 0 1 1 1 1 40S ribosomal protein SA C-terminus Amidoligase_2 PF12224.8 EGD98353.1 - 2.7e-07 30.5 0.0 3.3e-06 27.0 0.0 2.1 1 1 0 1 1 1 1 Putative amidoligase enzyme PseudoU_synth_1 PF01416.20 EGD98354.1 - 4.8e-35 120.3 0.0 1.9e-34 118.4 0.0 2.0 2 0 0 2 2 2 1 tRNA pseudouridine synthase Pox_A_type_inc PF04508.12 EGD98354.1 - 0.0057 16.5 0.2 0.014 15.2 0.2 1.7 1 0 0 1 1 1 1 Viral A-type inclusion protein repeat PIG-H PF10181.9 EGD98355.1 - 7.2e-27 93.1 0.3 1.6e-26 91.9 0.3 1.6 1 0 0 1 1 1 1 GPI-GlcNAc transferase complex, PIG-H component YukD PF08817.10 EGD98356.1 - 0.0027 18.4 0.0 0.0042 17.7 0.0 1.3 1 0 0 1 1 1 1 WXG100 protein secretion system (Wss), protein YukD ubiquitin PF00240.23 EGD98356.1 - 0.0027 17.4 0.0 0.0043 16.8 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin family Presenilin PF01080.17 EGD98356.1 - 3.9 6.1 3.9 4.2 6.0 3.9 1.2 1 0 0 1 1 1 0 Presenilin Pribosyl_synth PF14572.6 EGD98357.1 - 7.1e-41 140.3 2.4 2e-36 125.7 0.8 2.4 1 1 1 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran_N PF13793.6 EGD98357.1 - 8.9e-34 115.9 0.0 2e-33 114.8 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyltran PF00156.27 EGD98357.1 - 8.9e-14 51.3 0.3 1.9e-13 50.3 0.3 1.5 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 EGD98357.1 - 0.00044 19.7 0.2 0.00069 19.1 0.2 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase vATP-synt_AC39 PF01992.16 EGD98358.1 - 6.6e-109 364.5 0.1 7.4e-109 364.3 0.1 1.0 1 0 0 1 1 1 1 ATP synthase (C/AC39) subunit Nop PF01798.18 EGD98359.1 - 1.6e-83 279.7 0.5 1.6e-83 279.7 0.5 1.9 2 0 0 2 2 2 1 snoRNA binding domain, fibrillarin NOP5NT PF08156.13 EGD98359.1 - 1.2e-21 76.9 1.1 1.2e-21 76.9 1.1 3.0 3 0 0 3 3 3 1 NOP5NT (NUC127) domain RNA_pol_Rpb4 PF03874.16 EGD98360.1 - 3.1e-07 30.7 0.6 0.014 15.7 0.0 2.5 2 1 0 2 2 2 2 RNA polymerase Rpb4 DASH_Spc19 PF08287.11 EGD98361.1 - 5.2 6.9 11.0 3.8 7.4 0.1 3.3 3 1 0 3 3 3 0 Spc19 PARP PF00644.20 EGD98363.1 - 1.1e-10 41.4 0.2 2.2e-10 40.5 0.2 1.4 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain UQ_con PF00179.26 EGD98363.1 - 3.7e-08 33.1 0.0 7.7e-08 32.1 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 EGD98363.1 - 0.016 15.4 0.0 0.084 13.2 0.0 2.2 2 0 0 2 2 2 0 RWD domain Aft1_HRR PF11787.8 EGD98364.1 - 1.9e-18 67.4 1.7 1.9e-18 67.4 1.7 4.1 3 1 1 4 4 4 1 Aft1 HRR domain Aft1_HRA PF11786.8 EGD98364.1 - 3.7e-18 65.6 11.8 3.7e-18 65.6 11.8 3.5 3 1 1 4 4 4 1 Aft1 HRA domain Aft1_OSA PF11785.8 EGD98364.1 - 6.2e-14 52.2 8.9 9e-14 51.7 5.7 2.9 2 0 0 2 2 2 1 Aft1 osmotic stress response (OSM) domain bZIP_1 PF00170.21 EGD98364.1 - 5.8e-08 32.7 10.7 9.4e-08 32.0 10.7 1.3 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 EGD98364.1 - 0.0032 17.5 9.7 0.0063 16.6 9.7 1.5 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.17 EGD98364.1 - 0.045 14.3 4.7 0.09 13.3 4.7 1.4 1 0 0 1 1 1 0 bZIP Maf transcription factor HeLo PF14479.6 EGD98364.1 - 0.1 12.5 0.9 0.16 11.8 0.9 1.3 1 0 0 1 1 1 0 Prion-inhibition and propagation DUF615 PF04751.14 EGD98364.1 - 0.11 12.4 1.8 0.19 11.7 1.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF615) Nop53 PF07767.11 EGD98364.1 - 0.19 11.1 13.5 0.29 10.5 13.5 1.2 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) Transthyretin PF00576.21 EGD98365.1 - 2.6e-29 102.1 0.0 3.5e-29 101.7 0.0 1.2 1 0 0 1 1 1 1 HIUase/Transthyretin family NAD_binding_6 PF08030.12 EGD98366.1 - 2.7e-17 63.3 0.0 4.1e-17 62.7 0.0 1.3 1 0 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 EGD98366.1 - 0.0018 18.4 0.0 0.011 15.8 0.0 2.2 3 0 0 3 3 3 1 FAD-binding domain NAD_binding_1 PF00175.21 EGD98366.1 - 0.0042 17.7 0.0 0.36 11.5 0.0 2.3 1 1 0 1 1 1 1 Oxidoreductase NAD-binding domain Ferric_reduct PF01794.19 EGD98367.1 - 2.9e-16 59.7 22.8 3.2e-16 59.6 19.7 2.6 2 1 0 2 2 2 1 Ferric reductase like transmembrane component ArsA_ATPase PF02374.15 EGD98368.1 - 3.9e-113 377.7 0.0 4.5e-113 377.5 0.0 1.0 1 0 0 1 1 1 1 Anion-transporting ATPase AAA_31 PF13614.6 EGD98368.1 - 1.1e-13 51.5 0.3 4.4e-12 46.3 0.0 2.6 2 1 0 2 2 2 1 AAA domain CbiA PF01656.23 EGD98368.1 - 1.6e-12 47.6 0.0 3.2e-12 46.6 0.0 1.7 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain Fer4_NifH PF00142.18 EGD98368.1 - 6.7e-06 25.7 0.0 1.5e-05 24.6 0.0 1.6 1 0 0 1 1 1 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family ParA PF10609.9 EGD98368.1 - 7.2e-06 25.6 1.0 0.00019 21.0 0.1 2.3 2 0 0 2 2 2 1 NUBPL iron-transfer P-loop NTPase SRP54 PF00448.22 EGD98368.1 - 1.5e-05 24.7 0.2 0.00065 19.4 0.0 2.6 3 0 0 3 3 3 1 SRP54-type protein, GTPase domain CBP_BcsQ PF06564.12 EGD98368.1 - 8.4e-05 22.2 0.0 0.00029 20.4 0.0 1.8 2 0 0 2 2 2 1 Cellulose biosynthesis protein BcsQ PhoH PF02562.16 EGD98368.1 - 0.058 12.8 0.0 0.15 11.5 0.0 1.6 2 0 0 2 2 2 0 PhoH-like protein NB-ARC PF00931.22 EGD98368.1 - 0.077 12.2 0.0 0.2 10.8 0.0 1.6 1 0 0 1 1 1 0 NB-ARC domain AAA_18 PF13238.6 EGD98368.1 - 0.16 12.5 0.0 0.9 10.1 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 EGD98368.1 - 0.21 11.2 0.1 0.73 9.4 0.0 1.8 2 0 0 2 2 2 0 AAA domain eIF3_N PF09440.10 EGD98371.1 - 2.1e-48 164.1 2.4 5.3e-48 162.8 2.4 1.7 1 0 0 1 1 1 1 eIF3 subunit 6 N terminal domain PCI PF01399.27 EGD98371.1 - 4.6e-14 52.8 0.0 1.4e-13 51.3 0.0 1.9 1 0 0 1 1 1 1 PCI domain Img2 PF05046.14 EGD98372.1 - 6.2e-26 90.5 0.0 9e-26 90.0 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial large subunit ribosomal protein (Img2) ARID PF01388.21 EGD98373.1 - 1.5e-18 67.2 0.0 1.5e-18 67.2 0.0 2.3 2 1 0 2 2 2 1 ARID/BRIGHT DNA binding domain Cnd2 PF05786.14 EGD98373.1 - 7.9e-05 21.5 0.2 7.9e-05 21.5 0.2 2.7 2 1 1 3 3 3 1 Condensin complex subunit 2 Queuosine_synth PF02547.15 EGD98374.1 - 0.087 11.9 0.0 0.12 11.5 0.0 1.1 1 0 0 1 1 1 0 Queuosine biosynthesis protein Pkinase PF00069.25 EGD98375.1 - 6e-06 25.8 0.1 1.6e-05 24.4 0.1 1.6 1 1 1 2 2 2 1 Protein kinase domain R3H PF01424.22 EGD98376.1 - 5.3e-13 48.7 0.0 4.9e-12 45.7 0.1 2.3 2 0 0 2 2 2 1 R3H domain zf-NF-X1 PF01422.17 EGD98376.1 - 0.00019 21.4 80.5 0.00073 19.5 14.5 14.4 15 2 1 16 16 16 7 NF-X1 type zinc finger zf-LYAR PF08790.11 EGD98377.1 - 4.7e-14 52.0 3.5 4.7e-14 52.0 3.5 2.0 2 0 0 2 2 2 1 LYAR-type C2HC zinc finger RNHCP PF12647.7 EGD98377.1 - 1.9 8.5 6.2 7.5 6.6 6.2 1.9 1 1 0 1 1 1 0 RNHCP domain Evr1_Alr PF04777.13 EGD98378.1 - 5.4e-12 46.1 0.0 7.6e-12 45.6 0.0 1.3 1 0 0 1 1 1 1 Erv1 / Alr family MFS_1 PF07690.16 EGD98379.1 - 1.5e-19 70.2 60.3 2.2e-17 63.0 54.5 3.9 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EGD98379.1 - 1.4e-08 33.7 29.8 1.7e-08 33.4 15.8 2.2 1 1 1 2 2 2 2 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 EGD98379.1 - 6.5e-07 28.6 38.3 6.6e-06 25.2 15.0 2.5 3 0 0 3 3 3 2 Sugar (and other) transporter DUF2109 PF09882.9 EGD98379.1 - 3.6 7.7 9.0 0.4 10.7 1.3 3.5 3 0 0 3 3 3 0 Predicted membrane protein (DUF2109) MFS_1 PF07690.16 EGD98380.1 - 1.7e-47 162.0 36.5 1.7e-47 162.0 36.5 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EGD98380.1 - 5.1e-11 42.1 11.5 5.1e-11 42.1 11.5 2.8 2 1 1 3 3 3 1 Sugar (and other) transporter TRI12 PF06609.13 EGD98380.1 - 3.8e-06 25.6 1.8 3.8e-06 25.6 1.8 1.5 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) GFA PF04828.14 EGD98381.1 - 6.3e-11 42.5 0.5 1.4e-05 25.3 0.0 2.3 1 1 1 2 2 2 2 Glutathione-dependent formaldehyde-activating enzyme Acetyltransf_1 PF00583.25 EGD98382.1 - 1.3e-08 35.1 0.0 2.2e-08 34.3 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EGD98382.1 - 5.4e-07 29.6 0.0 2.2e-06 27.6 0.0 1.8 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EGD98382.1 - 1.2e-05 25.6 0.0 2.1e-05 24.9 0.0 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EGD98382.1 - 9.7e-05 22.5 0.1 0.001 19.2 0.0 2.1 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_6 PF13480.7 EGD98382.1 - 0.013 15.6 0.0 0.056 13.6 0.0 1.8 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain FR47 PF08445.10 EGD98382.1 - 0.044 13.8 0.0 0.43 10.6 0.0 2.3 2 0 0 2 2 2 0 FR47-like protein Acetyltransf_CG PF14542.6 EGD98382.1 - 0.14 12.3 0.0 0.29 11.3 0.0 1.5 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase Acetyltransf_7 PF13508.7 EGD98383.1 - 0.0056 17.1 0.0 0.014 15.9 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EGD98383.1 - 0.072 13.2 0.0 0.14 12.3 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EGD98383.1 - 0.1 12.9 0.0 0.28 11.4 0.0 1.8 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family Peptidase_S10 PF00450.22 EGD98384.1 - 1.4e-71 242.1 0.0 2.6e-71 241.2 0.0 1.3 1 0 0 1 1 1 1 Serine carboxypeptidase fn3_2 PF16893.5 EGD98385.1 - 7.6e-38 128.6 0.1 1.3e-37 127.8 0.1 1.4 1 0 0 1 1 1 1 Fibronectin type III domain CHS5_N PF16892.5 EGD98385.1 - 7.3e-24 83.5 0.5 1.4e-23 82.5 0.5 1.5 1 0 0 1 1 1 1 Chitin biosynthesis protein CHS5 N-terminus PTCB-BRCT PF12738.7 EGD98385.1 - 1.4e-14 53.8 0.0 2.6e-14 52.9 0.0 1.5 1 0 0 1 1 1 1 twin BRCT domain BRCT PF00533.26 EGD98385.1 - 1.7e-07 31.5 0.0 3e-07 30.7 0.0 1.4 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain DUF3006 PF11213.8 EGD98385.1 - 1.3e-05 25.3 0.0 4.4e-05 23.6 0.0 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF3006) BRCT_2 PF16589.5 EGD98385.1 - 4e-05 23.9 0.0 8.9e-05 22.8 0.0 1.5 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain fn3 PF00041.21 EGD98385.1 - 0.0022 18.3 0.0 0.0084 16.4 0.0 1.9 1 1 0 1 1 1 1 Fibronectin type III domain ERCC4 PF02732.15 EGD98386.1 - 4.2e-18 66.0 0.0 2.2e-17 63.7 0.0 2.3 3 0 0 3 3 3 1 ERCC4 domain HHH_5 PF14520.6 EGD98386.1 - 0.1 13.2 0.2 0.78 10.4 0.0 2.4 2 0 0 2 2 2 0 Helix-hairpin-helix domain eIF-1a PF01176.19 EGD98387.1 - 4.7e-22 77.6 0.0 6.5e-22 77.1 0.0 1.2 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 WH1 PF00568.23 EGD98389.1 - 1.6e-28 98.9 0.0 2.4e-28 98.3 0.0 1.2 1 0 0 1 1 1 1 WH1 domain WH2 PF02205.20 EGD98389.1 - 0.0025 17.6 2.5 0.0038 17.0 0.1 2.5 2 0 0 2 2 2 1 WH2 motif CorA PF01544.18 EGD98390.1 - 3e-09 36.6 0.0 5.7e-09 35.7 0.0 1.4 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein ApoL PF05461.11 EGD98390.1 - 0.078 12.3 0.2 0.12 11.7 0.2 1.3 1 0 0 1 1 1 0 Apolipoprotein L CAP59_mtransfer PF11735.8 EGD98392.1 - 7e-71 238.7 0.0 1.2e-70 238.0 0.0 1.4 1 0 0 1 1 1 1 Cryptococcal mannosyltransferase 1 SUIM_assoc PF16619.5 EGD98392.1 - 0.09 12.8 3.9 0.23 11.5 3.9 1.6 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 SEN1_N PF12726.7 EGD98393.1 - 6e-209 696.0 6.7 8.1e-209 695.6 6.7 1.2 1 0 0 1 1 1 1 SEN1 N terminal AAA_11 PF13086.6 EGD98393.1 - 4.5e-72 243.0 2.8 4.5e-72 243.0 2.8 2.3 3 0 0 3 3 3 1 AAA domain AAA_12 PF13087.6 EGD98393.1 - 6e-60 202.3 0.0 1.4e-59 201.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EGD98393.1 - 5.3e-09 36.1 0.1 1.9e-05 24.5 0.0 2.6 2 0 0 2 2 2 2 AAA domain UvrD-helicase PF00580.21 EGD98393.1 - 1.3e-07 31.4 2.0 1e-05 25.3 0.2 3.1 2 1 0 2 2 2 1 UvrD/REP helicase N-terminal domain Viral_helicase1 PF01443.18 EGD98393.1 - 1.5e-07 31.4 0.1 0.015 15.1 0.0 3.6 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase AAA_19 PF13245.6 EGD98393.1 - 3.1e-07 30.8 0.0 1.6e-06 28.5 0.0 2.2 2 1 0 2 2 1 1 AAA domain zf-CCHC PF00098.23 EGD98393.1 - 0.0023 17.9 1.3 0.0023 17.9 1.3 3.5 3 0 0 3 3 2 2 Zinc knuckle DEAD PF00270.29 EGD98393.1 - 0.0025 17.6 0.1 0.01 15.6 0.1 2.1 1 0 0 1 1 1 1 DEAD/DEAH box helicase T2SSE PF00437.20 EGD98393.1 - 0.0094 15.0 0.0 0.026 13.6 0.0 1.7 1 0 0 1 1 1 1 Type II/IV secretion system protein ResIII PF04851.15 EGD98393.1 - 0.023 14.7 0.0 0.14 12.2 0.0 2.4 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit AAA_22 PF13401.6 EGD98393.1 - 0.1 12.9 0.0 2.4 8.4 0.0 3.1 2 0 0 2 2 2 0 AAA domain Med9 PF07544.13 EGD98393.1 - 0.11 12.6 1.9 0.46 10.6 1.9 2.1 1 0 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 Sigma70_r1_1 PF03979.14 EGD98393.1 - 0.38 10.8 2.3 0.62 10.2 0.8 2.2 2 0 0 2 2 1 0 Sigma-70 factor, region 1.1 zf-CCHC_5 PF14787.6 EGD98393.1 - 0.76 9.5 17.0 0.069 12.9 0.7 3.1 2 1 1 3 3 2 0 GAG-polyprotein viral zinc-finger HAUS6_N PF14661.6 EGD98393.1 - 2.5 7.6 10.9 0.32 10.5 5.6 2.2 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus zf-CCHC_2 PF13696.6 EGD98393.1 - 4.8 7.1 7.2 2.1 8.2 1.0 2.4 2 0 0 2 2 2 0 Zinc knuckle DUF4164 PF13747.6 EGD98393.1 - 6.2 7.2 7.6 5.8 7.3 5.1 2.3 2 0 0 2 2 1 0 Domain of unknown function (DUF4164) PhoLip_ATPase_C PF16212.5 EGD98394.1 - 1.8e-76 257.2 19.3 1.8e-76 257.2 19.3 2.2 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EGD98394.1 - 4.3e-19 68.0 1.4 8.9e-19 66.9 1.4 1.5 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.26 EGD98394.1 - 3.2e-10 40.7 1.1 7.2e-05 23.2 0.2 3.4 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 EGD98394.1 - 7e-05 22.4 0.1 0.0003 20.4 0.0 2.1 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase PF13246.6 EGD98394.1 - 0.00016 21.7 0.0 0.00081 19.4 0.0 2.1 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 EGD98394.1 - 0.023 14.5 0.2 0.054 13.2 0.2 1.5 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase vATP-synt_E PF01991.18 EGD98397.1 - 2.7e-59 199.9 11.2 3.2e-59 199.7 11.2 1.0 1 0 0 1 1 1 1 ATP synthase (E/31 kDa) subunit DUF4288 PF14119.6 EGD98397.1 - 0.014 15.7 5.1 4.6 7.7 0.5 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4288) IFS PF16718.5 EGD98397.1 - 0.066 13.3 0.7 0.33 11.0 0.5 1.9 2 0 0 2 2 2 0 Immunity factor for SPN Mg_trans_NIPA PF05653.14 EGD98398.1 - 4.2e-15 55.6 11.6 8.7e-09 34.9 2.1 2.1 2 0 0 2 2 2 2 Magnesium transporter NIPA EamA PF00892.20 EGD98398.1 - 3.1e-06 27.4 0.6 3.1e-06 27.4 0.6 3.2 4 0 0 4 4 4 2 EamA-like transporter family PUNUT PF16913.5 EGD98398.1 - 9.6e-05 21.8 0.5 9.6e-05 21.8 0.5 2.2 2 0 0 2 2 2 1 Purine nucleobase transmembrane transport UAA PF08449.11 EGD98398.1 - 0.0015 17.8 0.6 0.0023 17.2 0.6 1.3 1 1 0 1 1 1 1 UAA transporter family DUF4079 PF13301.6 EGD98398.1 - 0.012 15.8 0.4 0.012 15.8 0.4 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF4079) Multi_Drug_Res PF00893.19 EGD98398.1 - 0.021 15.5 5.4 0.15 12.7 0.1 2.8 2 0 0 2 2 2 0 Small Multidrug Resistance protein TMEM61 PF15105.6 EGD98398.1 - 0.049 13.5 0.0 0.089 12.6 0.0 1.4 1 0 0 1 1 1 0 TMEM61 protein family Lactonase PF10282.9 EGD98399.1 - 8.4e-86 288.3 0.0 1e-85 288.1 0.0 1.0 1 0 0 1 1 1 1 Lactonase, 7-bladed beta-propeller SRF-TF PF00319.18 EGD98400.1 - 3.7e-21 74.3 0.1 5.6e-21 73.8 0.1 1.3 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) Tetraspanin PF00335.20 EGD98401.1 - 0.77 9.4 9.1 4.2 7.0 9.1 2.3 1 1 0 1 1 1 0 Tetraspanin family Acetyltransf_7 PF13508.7 EGD98403.1 - 0.016 15.6 0.0 0.031 14.7 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EGD98403.1 - 0.046 14.0 0.0 0.57 10.4 0.0 2.2 2 0 0 2 2 2 0 Acetyltransferase (GNAT) family NAD_binding_6 PF08030.12 EGD98404.1 - 1.5e-19 70.7 0.0 4.9e-19 69.0 0.0 1.8 1 1 0 1 1 1 1 Ferric reductase NAD binding domain Ferric_reduct PF01794.19 EGD98404.1 - 1.6e-17 63.8 9.8 1.6e-17 63.8 9.8 2.3 2 0 0 2 2 2 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.12 EGD98404.1 - 2.2e-14 53.4 0.0 6.3e-14 52.0 0.0 1.8 1 1 0 1 1 1 1 FAD-binding domain NAD_binding_1 PF00175.21 EGD98404.1 - 0.0081 16.8 0.0 6.6 7.4 0.0 2.4 2 0 0 2 2 2 2 Oxidoreductase NAD-binding domain DUF4405 PF14358.6 EGD98404.1 - 0.013 16.0 1.0 0.013 16.0 1.0 3.1 2 1 0 2 2 2 0 Domain of unknown function (DUF4405) DUF2975 PF11188.8 EGD98404.1 - 0.17 11.8 0.0 0.17 11.8 0.0 3.0 3 1 0 3 3 3 0 Protein of unknown function (DUF2975) RNase_PH PF01138.21 EGD98405.1 - 4.1e-17 62.9 0.7 1.9e-15 57.6 0.7 2.4 1 1 0 1 1 1 1 3' exoribonuclease family, domain 1 Peptidase_A22B PF04258.13 EGD98406.1 - 2.2e-44 152.1 0.2 1e-43 149.9 0.1 2.1 1 1 1 2 2 2 1 Signal peptide peptidase SPP PF06550.11 EGD98406.1 - 4.1e-05 23.2 3.3 0.00013 21.6 3.3 1.8 1 1 0 1 1 1 1 Signal-peptide peptidase, presenilin aspartyl protease Pro_isomerase PF00160.21 EGD98407.1 - 5.2e-55 186.0 0.0 5.8e-55 185.9 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD GDI PF00996.18 EGD98408.1 - 3.3e-25 88.5 0.0 3.2e-24 85.2 0.0 2.2 1 1 0 1 1 1 1 GDP dissociation inhibitor DUF604 PF04646.12 EGD98409.1 - 1.5e-08 34.3 0.0 2.4e-08 33.7 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function, DUF604 Fringe PF02434.16 EGD98409.1 - 0.00084 18.9 0.0 0.0022 17.5 0.0 1.6 1 1 0 1 1 1 1 Fringe-like Phospholip_A2_3 PF09056.11 EGD98411.1 - 8.3e-40 135.9 4.9 9.8e-40 135.7 4.9 1.1 1 0 0 1 1 1 1 Prokaryotic phospholipase A2 zf-C2HC5 PF06221.13 EGD98412.1 - 5.7e-20 71.1 6.4 9.1e-20 70.4 6.4 1.3 1 0 0 1 1 1 1 Putative zinc finger motif, C2HC5-type Hexokinase_2 PF03727.16 EGD98413.1 - 2.5e-74 249.7 0.0 3.4e-74 249.3 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 EGD98413.1 - 2e-72 243.3 0.0 3e-72 242.7 0.0 1.3 1 0 0 1 1 1 1 Hexokinase Redoxin PF08534.10 EGD98414.1 - 2.2e-37 128.0 0.0 2.4e-37 127.9 0.0 1.0 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 EGD98414.1 - 1.6e-11 44.2 0.0 2.1e-11 43.8 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family POP1 PF06978.11 EGD98415.1 - 2.2e-74 249.9 16.3 4.3e-74 248.9 16.3 1.5 1 0 0 1 1 1 1 Ribonucleases P/MRP protein subunit POP1 POPLD PF08170.12 EGD98415.1 - 8.5e-33 112.6 1.7 8.5e-33 112.6 1.7 2.1 2 0 0 2 2 2 1 POPLD (NUC188) domain DUF1690 PF07956.11 EGD98416.1 - 6.8e-39 133.5 5.2 3e-19 69.8 2.4 2.0 2 0 0 2 2 2 2 Protein of Unknown function (DUF1690) Rootletin PF15035.6 EGD98416.1 - 0.018 15.1 1.3 0.18 11.8 0.3 2.1 2 0 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion DAO PF01266.24 EGD98417.1 - 3e-27 96.1 0.0 3.4e-27 96.0 0.0 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EGD98417.1 - 0.0061 15.8 0.0 0.011 15.0 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EGD98417.1 - 0.03 14.3 0.0 0.044 13.8 0.0 1.3 1 0 0 1 1 1 0 FAD-NAD(P)-binding Pkinase PF00069.25 EGD98419.1 - 2.6e-66 223.7 0.0 3e-65 220.2 0.0 2.2 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD98419.1 - 1.3e-33 116.4 0.0 1.2e-32 113.2 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Fungal_KA1 PF16797.5 EGD98419.1 - 5.3e-33 113.2 0.3 1.1e-32 112.2 0.3 1.6 1 0 0 1 1 1 1 Fungal kinase associated-1 domain Kinase-like PF14531.6 EGD98419.1 - 2.2e-05 23.9 0.0 3.8e-05 23.1 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 EGD98419.1 - 0.00049 19.2 0.0 0.0012 17.9 0.0 1.7 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 EGD98419.1 - 0.0043 16.4 0.0 0.0084 15.5 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EGD98419.1 - 0.047 13.6 0.1 0.24 11.3 0.0 2.0 1 1 1 2 2 2 0 Phosphotransferase enzyme family Zn_clus PF00172.18 EGD98420.1 - 8.2e-09 35.4 7.3 1.2e-08 34.9 7.3 1.2 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF3328 PF11807.8 EGD98421.1 - 1.3e-15 57.8 0.6 1.2e-14 54.6 0.6 2.0 1 1 0 1 1 1 1 Domain of unknown function (DUF3328) Methyltransf_2 PF00891.18 EGD98422.1 - 1.6e-28 99.5 0.0 2.5e-28 98.8 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_23 PF13489.6 EGD98422.1 - 2.6e-06 27.4 0.0 4.6e-06 26.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EGD98422.1 - 6.6e-05 23.5 0.3 0.0031 18.2 0.0 3.1 4 0 0 4 4 4 1 Methyltransferase domain CheR PF01739.18 EGD98422.1 - 0.0014 18.1 0.0 0.0029 17.1 0.0 1.4 1 0 0 1 1 1 1 CheR methyltransferase, SAM binding domain MTS PF05175.14 EGD98422.1 - 0.017 14.7 0.0 0.055 13.0 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase small domain Methyltransf_12 PF08242.12 EGD98422.1 - 0.14 12.9 0.0 0.73 10.6 0.0 2.3 2 1 0 2 2 2 0 Methyltransferase domain Myb_DNA-binding PF00249.31 EGD98423.1 - 3.5e-37 126.3 6.7 1e-12 48.1 0.2 3.3 3 0 0 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EGD98423.1 - 5.7e-28 96.9 3.8 1.1e-13 51.2 0.0 3.3 1 1 2 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 EGD98423.1 - 1.2e-05 25.1 0.1 0.0022 17.8 0.0 3.1 3 1 0 3 3 3 1 Myb DNA-binding like Myb_DNA-bind_4 PF13837.6 EGD98423.1 - 0.00047 20.5 7.1 0.37 11.2 0.1 3.8 3 1 0 3 3 3 2 Myb/SANT-like DNA-binding domain Rap1_C PF11626.8 EGD98423.1 - 0.003 17.6 0.0 0.71 10.0 0.0 2.8 1 1 1 2 2 2 2 TRF2-interacting telomeric protein/Rap1 - C terminal domain SANT_DAMP1_like PF16282.5 EGD98423.1 - 0.0057 16.8 2.7 0.03 14.5 0.2 3.2 1 1 2 3 3 3 1 SANT/Myb-like domain of DAMP1 FAD_binding_4 PF01565.23 EGD98424.1 - 3.4e-25 88.4 0.1 5.3e-25 87.8 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EGD98424.1 - 0.00078 19.5 0.2 0.0027 17.8 0.0 1.9 2 0 0 2 2 2 1 Berberine and berberine like PsbT PF01405.17 EGD98424.1 - 0.09 12.6 0.0 0.21 11.4 0.0 1.6 1 0 0 1 1 1 0 Photosystem II reaction centre T protein adh_short PF00106.25 EGD98425.1 - 1.5e-41 142.0 0.2 1.7e-41 141.8 0.2 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EGD98425.1 - 3.5e-29 102.0 0.4 4.1e-29 101.8 0.4 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EGD98425.1 - 3.4e-10 40.1 0.2 4.2e-10 39.8 0.2 1.1 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 EGD98425.1 - 0.00078 19.4 0.1 0.00083 19.3 0.1 1.2 1 0 0 1 1 1 1 NAD(P)H-binding DUF1776 PF08643.10 EGD98425.1 - 0.0021 17.5 0.0 0.0059 16.0 0.0 1.7 1 1 0 1 1 1 1 Fungal family of unknown function (DUF1776) 3HCDH_N PF02737.18 EGD98425.1 - 0.082 12.8 0.1 0.12 12.3 0.1 1.2 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain AA_permease PF00324.21 EGD98426.1 - 1.1e-119 400.2 37.1 1.2e-119 400.0 37.1 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EGD98426.1 - 8.6e-29 100.6 41.9 1e-28 100.4 41.9 1.0 1 0 0 1 1 1 1 Amino acid permease HTH_23 PF13384.6 EGD98427.1 - 1e-06 28.3 0.2 2.7e-06 27.0 0.1 1.8 2 0 0 2 2 2 1 Homeodomain-like domain Sigma70_r4_2 PF08281.12 EGD98427.1 - 4.9e-05 22.9 0.1 0.00065 19.3 0.1 2.2 2 0 0 2 2 2 1 Sigma-70, region 4 HTH_38 PF13936.6 EGD98427.1 - 5.5e-05 22.8 0.6 5.5e-05 22.8 0.6 2.2 2 0 0 2 2 2 1 Helix-turn-helix domain Mucin PF01456.17 EGD98427.1 - 0.00013 22.0 6.3 0.00016 21.7 6.3 1.3 1 0 0 1 1 1 1 Mucin-like glycoprotein HTH_32 PF13565.6 EGD98427.1 - 0.00015 22.3 3.7 0.0038 17.8 0.1 2.8 1 1 1 3 3 3 1 Homeodomain-like domain HTH_7 PF02796.15 EGD98427.1 - 0.0012 18.9 0.3 0.26 11.4 0.1 2.4 2 0 0 2 2 2 1 Helix-turn-helix domain of resolvase HTH_31 PF13560.6 EGD98427.1 - 0.0034 17.7 0.7 0.011 16.0 0.7 1.8 1 1 0 1 1 1 1 Helix-turn-helix domain GerE PF00196.19 EGD98427.1 - 0.0067 15.9 0.0 0.014 14.9 0.0 1.5 1 0 0 1 1 1 1 Bacterial regulatory proteins, luxR family HTH_28 PF13518.6 EGD98427.1 - 0.0084 16.2 0.3 0.0084 16.2 0.3 2.1 2 0 0 2 2 2 1 Helix-turn-helix domain Sigma70_r4 PF04545.16 EGD98427.1 - 0.028 13.9 0.1 0.12 11.9 0.1 2.0 2 0 0 2 2 2 0 Sigma-70, region 4 HTH_Tnp_1 PF01527.20 EGD98427.1 - 0.068 13.5 0.9 0.21 11.9 0.1 2.2 2 1 0 2 2 2 0 Transposase HTH_3 PF01381.22 EGD98427.1 - 0.1 12.7 0.7 0.2 11.8 0.2 1.8 2 0 0 2 2 2 0 Helix-turn-helix TMEM154 PF15102.6 EGD98427.1 - 4.1 7.3 10.0 6.2 6.7 10.0 1.2 1 0 0 1 1 1 0 TMEM154 protein family DUF3439 PF11921.8 EGD98427.1 - 6.6 6.7 10.8 13 5.7 10.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) KGG PF10685.9 EGD98428.1 - 3.1e-25 87.6 15.7 5.1e-10 39.3 0.5 3.3 3 0 0 3 3 3 3 Stress-induced bacterial acidophilic repeat motif Aminotran_5 PF00266.19 EGD98429.1 - 7.2e-16 58.1 0.0 1.1e-14 54.2 0.0 2.1 1 1 0 1 1 1 1 Aminotransferase class-V EutN_CcmL PF03319.13 EGD98429.1 - 0.13 12.9 0.0 0.28 11.8 0.0 1.5 1 0 0 1 1 1 0 Ethanolamine utilisation protein EutN/carboxysome UNC-93 PF05978.16 EGD98430.1 - 1.7e-05 24.6 2.3 1.7e-05 24.6 2.3 2.4 2 0 0 2 2 2 1 Ion channel regulatory protein UNC-93 CcmE PF03100.15 EGD98430.1 - 0.036 14.1 0.4 0.082 12.9 0.4 1.6 1 0 0 1 1 1 0 CcmE WD40 PF00400.32 EGD98431.1 - 1.5e-56 187.0 12.2 7.8e-11 42.4 0.6 8.0 7 1 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EGD98431.1 - 6e-24 84.2 0.0 3.7e-05 23.9 0.0 5.9 2 1 4 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EGD98431.1 - 2.5e-08 33.2 0.2 0.06 12.3 0.0 4.6 1 1 4 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 EGD98431.1 - 2.9e-08 32.8 0.3 0.086 11.5 0.0 4.6 2 2 2 4 4 4 2 Nucleoporin Nup120/160 WD40_like PF17005.5 EGD98431.1 - 1.5e-05 24.5 0.0 0.0002 20.8 0.0 2.6 2 1 1 3 3 3 1 WD40-like domain PD40 PF07676.12 EGD98431.1 - 6.7e-05 22.7 2.0 0.9 9.6 0.1 4.8 5 0 0 5 5 5 1 WD40-like Beta Propeller Repeat DUF1513 PF07433.11 EGD98431.1 - 0.0076 15.4 0.1 0.29 10.2 0.0 2.9 1 1 1 3 3 3 1 Protein of unknown function (DUF1513) Nbas_N PF15492.6 EGD98431.1 - 0.021 14.1 0.5 6.3 6.0 0.0 3.4 1 1 2 4 4 4 0 Neuroblastoma-amplified sequence, N terminal Frtz PF11768.8 EGD98431.1 - 0.042 12.2 0.0 0.14 10.5 0.0 1.7 2 1 0 2 2 2 0 WD repeat-containing and planar cell polarity effector protein Fritz RAB3GAP2_N PF14655.6 EGD98431.1 - 0.15 11.3 0.0 0.59 9.3 0.0 2.0 3 0 0 3 3 3 0 Rab3 GTPase-activating protein regulatory subunit N-terminus PALB2_WD40 PF16756.5 EGD98431.1 - 0.19 10.6 0.2 13 4.6 0.1 2.8 2 1 0 2 2 2 0 Partner and localizer of BRCA2 WD40 domain Exo_endo_phos PF03372.23 EGD98432.1 - 3.3e-13 49.7 0.1 5.1e-13 49.1 0.1 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Thi4 PF01946.17 EGD98433.1 - 3.3e-108 360.3 0.0 4e-108 360.1 0.0 1.1 1 0 0 1 1 1 1 Thi4 family DAO PF01266.24 EGD98433.1 - 6.5e-07 29.3 0.0 7.4e-07 29.1 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EGD98433.1 - 1.3e-05 25.3 0.1 7.9e-05 22.8 0.1 2.4 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 EGD98433.1 - 0.00019 20.6 0.3 0.00034 19.8 0.3 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein Pyr_redox_2 PF07992.14 EGD98433.1 - 0.0018 17.6 0.0 0.0026 17.0 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EGD98433.1 - 0.0034 17.4 0.1 0.015 15.3 0.1 2.0 2 0 0 2 2 2 1 FAD-NAD(P)-binding Trp_halogenase PF04820.14 EGD98433.1 - 0.077 11.8 0.2 0.11 11.3 0.2 1.2 1 0 0 1 1 1 0 Tryptophan halogenase FAD_binding_3 PF01494.19 EGD98433.1 - 0.088 12.0 0.1 0.13 11.5 0.1 1.2 1 0 0 1 1 1 0 FAD binding domain FAD_binding_2 PF00890.24 EGD98433.1 - 0.12 11.4 0.3 0.3 10.1 0.3 1.6 2 0 0 2 2 2 0 FAD binding domain ACC_epsilon PF13822.6 EGD98434.1 - 2.1 9.1 8.6 1.8 9.3 1.1 2.5 2 0 0 2 2 2 0 Acyl-CoA carboxylase epsilon subunit Ppx-GppA PF02541.16 EGD98435.1 - 2.8e-39 135.3 0.0 1.7e-38 132.7 0.0 1.9 1 1 0 1 1 1 1 Ppx/GppA phosphatase family Proteasome PF00227.26 EGD98436.1 - 1.2e-46 158.6 0.1 1.5e-46 158.3 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Pil1 PF13805.6 EGD98437.1 - 3.1e-84 282.6 1.2 3.8e-84 282.3 1.2 1.0 1 0 0 1 1 1 1 Eisosome component PIL1 SWI-SNF_Ssr4 PF08549.10 EGD98438.1 - 6.5e-247 821.8 16.4 2.8e-246 819.7 16.4 1.7 1 1 0 1 1 1 1 Fungal domain of unknown function (DUF1750) DUF4832 PF16116.5 EGD98438.1 - 0.16 11.8 0.3 0.37 10.6 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4832) MRPL52 PF18699.1 EGD98438.1 - 0.45 10.7 1.9 0.65 10.2 0.2 2.1 2 0 0 2 2 2 0 Mitoribosomal protein mL52 RNA_pol_Rpb2_6 PF00562.28 EGD98439.1 - 2.9e-116 388.8 0.0 3.8e-116 388.3 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 EGD98439.1 - 7.7e-39 133.3 0.0 1.2e-38 132.7 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_3 PF04565.16 EGD98439.1 - 1.5e-27 95.6 0.0 3.1e-27 94.5 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_2 PF04561.14 EGD98439.1 - 1.7e-27 96.3 0.0 3e-27 95.5 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpa2_4 PF06883.12 EGD98439.1 - 4.5e-25 87.4 0.0 1.1e-24 86.2 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase I, Rpa2 specific domain RNA_pol_Rpb2_7 PF04560.20 EGD98439.1 - 6.4e-16 58.5 0.0 1.4e-14 54.2 0.0 2.4 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 7 PS-DH PF14765.6 EGD98441.1 - 1.5e-61 208.2 0.0 2.4e-61 207.6 0.0 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase Acyl_transf_1 PF00698.21 EGD98441.1 - 1.2e-58 199.2 0.0 5.5e-58 197.0 0.0 1.9 2 0 0 2 2 2 1 Acyl transferase domain KR PF08659.10 EGD98441.1 - 4.2e-58 196.2 0.0 3.6e-57 193.2 0.0 2.6 2 0 0 2 2 2 1 KR domain ketoacyl-synt PF00109.26 EGD98441.1 - 6.9e-56 189.6 0.0 1.4e-55 188.6 0.0 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain KAsynt_C_assoc PF16197.5 EGD98441.1 - 2.7e-23 82.6 0.0 5.7e-23 81.5 0.0 1.6 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension ADH_zinc_N PF00107.26 EGD98441.1 - 1.5e-16 60.5 0.0 4.2e-16 59.1 0.0 1.8 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EGD98441.1 - 3.6e-16 60.4 0.0 4.8e-15 56.8 0.0 2.6 2 0 0 2 2 2 1 Zinc-binding dehydrogenase Methyltransf_12 PF08242.12 EGD98441.1 - 3.5e-15 56.5 0.0 8.4e-15 55.3 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EGD98441.1 - 5.5e-13 49.1 0.0 1.3e-12 47.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain adh_short PF00106.25 EGD98441.1 - 1.7e-12 47.2 0.4 3.6e-09 36.4 0.0 3.2 3 0 0 3 3 3 2 short chain dehydrogenase Ketoacyl-synt_C PF02801.22 EGD98441.1 - 1.7e-12 47.4 0.0 5.6e-12 45.7 0.0 2.0 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Methyltransf_31 PF13847.6 EGD98441.1 - 8.3e-10 38.7 0.0 1.7e-09 37.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EGD98441.1 - 3.6e-09 37.2 0.0 1.1e-08 35.7 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EGD98441.1 - 9.1e-09 35.9 0.0 2.9e-08 34.2 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain PP-binding PF00550.25 EGD98441.1 - 0.00012 22.4 0.0 0.00031 21.0 0.0 1.8 1 0 0 1 1 1 1 Phosphopantetheine attachment site Ubie_methyltran PF01209.18 EGD98441.1 - 0.00018 21.0 0.0 0.00038 19.8 0.0 1.5 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family ADH_N PF08240.12 EGD98441.1 - 0.00035 20.4 0.0 0.001 18.9 0.0 1.8 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Methyltransf_16 PF10294.9 EGD98441.1 - 0.0015 18.3 0.0 0.017 14.8 0.0 2.3 2 0 0 2 2 2 1 Lysine methyltransferase SAT PF16073.5 EGD98441.1 - 0.056 13.2 0.0 3 7.5 0.0 2.8 3 0 0 3 3 3 0 Starter unit:ACP transacylase in aflatoxin biosynthesis Rsm22 PF09243.10 EGD98441.1 - 0.06 12.6 0.0 0.17 11.2 0.0 1.6 2 0 0 2 2 2 0 Mitochondrial small ribosomal subunit Rsm22 Arf PF00025.21 EGD98442.1 - 1.6e-43 148.1 0.0 1.9e-43 147.9 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 EGD98442.1 - 5.5e-20 71.6 0.0 6.2e-20 71.4 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EGD98442.1 - 3.5e-15 56.3 0.0 5.2e-15 55.7 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 EGD98442.1 - 2.9e-08 33.8 0.0 4.2e-08 33.3 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 EGD98442.1 - 1.9e-06 27.5 0.0 2.1e-06 27.3 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 EGD98442.1 - 2.4e-06 27.1 0.0 2.9e-06 26.8 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region G-alpha PF00503.20 EGD98442.1 - 7.2e-05 22.1 0.0 0.00058 19.1 0.0 2.2 1 1 1 2 2 2 1 G-protein alpha subunit MMR_HSR1_Xtn PF16897.5 EGD98442.1 - 0.00064 19.7 0.0 0.0011 18.9 0.0 1.3 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain Dynamin_N PF00350.23 EGD98442.1 - 0.0024 17.9 0.1 0.035 14.2 0.2 2.1 1 1 1 2 2 2 1 Dynamin family FeoB_N PF02421.18 EGD98442.1 - 0.022 14.3 0.2 0.061 12.9 0.0 1.7 3 0 0 3 3 3 0 Ferrous iron transport protein B RsgA_GTPase PF03193.16 EGD98442.1 - 0.081 12.8 0.1 9 6.2 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase DUF1979 PF09322.10 EGD98442.1 - 0.17 11.8 1.6 3.5 7.6 0.4 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1979) RCR PF12273.8 EGD98443.1 - 2.6e-18 66.8 9.2 2.6e-18 66.8 9.2 1.4 2 0 0 2 2 2 1 Chitin synthesis regulation, resistance to Congo red SARAF PF06682.12 EGD98443.1 - 0.00039 20.2 1.7 0.00046 19.9 1.7 1.2 1 0 0 1 1 1 1 SOCE-associated regulatory factor of calcium homoeostasis DUF2868 PF11067.8 EGD98443.1 - 0.0014 18.2 0.3 0.0015 18.1 0.3 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2868) TMEM51 PF15345.6 EGD98443.1 - 0.018 14.9 0.1 0.029 14.2 0.1 1.3 1 1 0 1 1 1 0 Transmembrane protein 51 DUF3328 PF11807.8 EGD98443.1 - 0.04 13.7 0.0 0.051 13.3 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3328) Corona_S2 PF01601.16 EGD98444.1 - 2.1 6.7 16.8 2.9 6.3 16.8 1.1 1 0 0 1 1 1 0 Coronavirus S2 glycoprotein MFS_1 PF07690.16 EGD98445.1 - 2.4e-10 39.9 49.1 2.4e-10 39.9 38.1 2.6 2 1 1 3 3 3 2 Major Facilitator Superfamily MFS_4 PF06779.14 EGD98445.1 - 0.00068 19.0 20.5 0.00091 18.6 20.5 1.1 1 0 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB EMC3_TMCO1 PF01956.16 EGD98445.1 - 6.9 6.4 5.6 1.8 8.3 0.2 2.3 2 0 0 2 2 2 0 Integral membrane protein EMC3/TMCO1-like CwfJ_C_1 PF04677.15 EGD98447.1 - 8.9e-25 86.9 0.0 1.5e-24 86.2 0.0 1.3 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 CwfJ_C_2 PF04676.14 EGD98447.1 - 2.3e-16 60.5 0.2 5.6e-16 59.2 0.2 1.7 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 2 Toxin_38 PF14866.6 EGD98447.1 - 0.17 12.2 0.0 0.33 11.3 0.0 1.4 1 0 0 1 1 1 0 Potassium channel toxin DRIM PF07539.12 EGD98448.1 - 7e-185 615.9 11.9 2.9e-184 613.9 0.7 4.1 4 0 0 4 4 4 2 Down-regulated in metastasis HEAT PF02985.22 EGD98448.1 - 0.00018 21.5 2.6 0.73 10.3 0.0 6.1 6 0 0 6 6 6 1 HEAT repeat KAR PF15222.6 EGD98448.1 - 0.00057 20.2 0.2 0.0026 18.0 0.1 2.2 2 0 0 2 2 2 1 Kidney androgen-regulated Wap1 PF16997.5 EGD98448.1 - 0.019 14.1 0.0 3.4 6.7 0.0 3.5 3 0 0 3 3 3 0 Wap1 domain HTH_37 PF13744.6 EGD98448.1 - 3.5 7.7 5.2 64 3.6 0.0 4.3 4 0 0 4 4 4 0 Helix-turn-helix domain zf-DNL PF05180.12 EGD98449.1 - 1.3e-27 95.5 0.4 2.3e-27 94.7 0.4 1.4 1 0 0 1 1 1 1 DNL zinc finger TFIIS_C PF01096.18 EGD98449.1 - 0.0097 15.7 1.1 1.4 8.8 0.2 2.4 2 0 0 2 2 2 2 Transcription factor S-II (TFIIS) zf-CSL PF05207.13 EGD98449.1 - 0.018 14.8 0.1 0.032 13.9 0.1 1.4 1 0 0 1 1 1 0 CSL zinc finger Elf1 PF05129.13 EGD98449.1 - 0.077 13.0 0.3 0.14 12.2 0.3 1.3 1 0 0 1 1 1 0 Transcription elongation factor Elf1 like zinc_ribbon_4 PF13717.6 EGD98449.1 - 0.23 11.4 2.1 0.51 10.3 0.1 2.3 2 0 0 2 2 2 0 zinc-ribbon domain E7 PF00527.18 EGD98449.1 - 0.65 10.2 3.5 1.4 9.2 1.7 2.4 2 1 0 2 2 2 0 E7 protein, Early protein Cullin PF00888.22 EGD98450.1 - 6.6e-200 665.8 7.9 6.6e-200 665.8 7.9 1.4 2 0 0 2 2 2 1 Cullin family Cullin_Nedd8 PF10557.9 EGD98450.1 - 1.9e-27 95.1 1.2 6.8e-27 93.3 0.8 2.3 2 0 0 2 2 2 1 Cullin protein neddylation domain DUF1737 PF08410.10 EGD98450.1 - 0.11 12.3 0.1 0.32 10.9 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1737) HEPN_DZIP3 PF18738.1 EGD98450.1 - 0.18 11.5 1.4 18 5.1 0.0 2.9 2 1 0 2 2 2 0 DZIP3/ hRUL138-like HEPN Kinesin_assoc PF16183.5 EGD98450.1 - 1.2 9.3 7.3 4.1 7.5 0.1 3.2 3 0 0 3 3 3 0 Kinesin-associated SLD5_C PF16922.5 EGD98451.1 - 3.9e-11 43.0 0.1 6.5e-11 42.3 0.1 1.4 1 0 0 1 1 1 1 DNA replication complex GINS protein SLD5 C-terminus Sld5 PF05916.11 EGD98451.1 - 0.0047 17.4 0.1 0.0067 16.9 0.1 1.2 1 0 0 1 1 1 1 GINS complex protein Rhodanese PF00581.20 EGD98452.1 - 7e-14 52.3 0.1 1.5e-13 51.1 0.1 1.6 1 0 0 1 1 1 1 Rhodanese-like domain OAD_gamma PF04277.13 EGD98453.1 - 0.011 16.3 0.1 0.014 15.9 0.1 1.2 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain BatD PF13584.6 EGD98453.1 - 0.044 12.6 1.1 0.053 12.3 1.1 1.1 1 0 0 1 1 1 0 Oxygen tolerance DUF2615 PF11027.8 EGD98453.1 - 0.059 13.5 0.2 0.086 13.0 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2615) Connexin PF00029.19 EGD98453.1 - 0.061 13.1 0.6 0.073 12.8 0.6 1.1 1 0 0 1 1 1 0 Connexin HA2 PF04408.23 EGD98453.1 - 0.091 13.1 0.8 0.1 12.9 0.8 1.3 1 1 0 1 1 1 0 Helicase associated domain (HA2) DUF92 PF01940.16 EGD98453.1 - 0.24 10.8 0.5 0.3 10.5 0.5 1.1 1 0 0 1 1 1 0 Integral membrane protein DUF92 TMEMspv1-c74-12 PF11044.8 EGD98453.1 - 0.25 11.3 6.4 0.54 10.3 6.4 1.6 1 0 0 1 1 1 0 Plectrovirus spv1-c74 ORF 12 transmembrane protein Conotoxin PF02950.17 EGD98453.1 - 0.29 12.2 1.2 0.56 11.3 1.2 1.6 1 1 0 1 1 1 0 Conotoxin FAM176 PF14851.6 EGD98453.1 - 1.7 8.3 5.2 6.5 6.4 5.2 1.8 1 1 0 1 1 1 0 FAM176 family LapA_dom PF06305.11 EGD98453.1 - 2.4 8.1 9.6 0.19 11.6 4.5 1.8 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain YajC PF02699.15 EGD98453.1 - 2.6 8.0 7.1 14 5.7 7.1 2.0 1 1 0 1 1 1 0 Preprotein translocase subunit Iso_dh PF00180.20 EGD98454.1 - 3.9e-83 279.5 0.0 4.8e-83 279.2 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase DNA_pol_phi PF04931.13 EGD98455.1 - 4e-246 818.9 11.7 4.9e-246 818.6 11.7 1.1 1 0 0 1 1 1 1 DNA polymerase phi FANCI_S3 PF14677.6 EGD98455.1 - 0.023 14.4 3.8 0.71 9.5 0.1 3.4 3 0 0 3 3 3 0 FANCI solenoid 3 TINF2_N PF14973.6 EGD98455.1 - 0.24 11.7 3.3 8.5 6.7 0.1 2.8 3 0 0 3 3 3 0 TERF1-interacting nuclear factor 2 N-terminus SDA1 PF05285.12 EGD98455.1 - 0.33 10.3 26.5 0.017 14.6 20.4 1.9 2 0 0 2 2 2 0 SDA1 TPT PF03151.16 EGD98456.1 - 1.8e-22 80.1 18.4 2.3e-22 79.7 18.4 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 EGD98456.1 - 1.3e-05 25.4 39.5 0.00075 19.7 17.7 2.4 2 1 0 2 2 2 2 EamA-like transporter family AD PF09793.9 EGD98457.1 - 8.9e-26 89.8 0.0 2.1e-25 88.7 0.0 1.6 1 0 0 1 1 1 1 Anticodon-binding domain RRM_1 PF00076.22 EGD98458.1 - 4.6e-18 64.8 0.0 7.6e-18 64.1 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TFIIA PF03153.13 EGD98458.1 - 9.3 6.1 22.1 15 5.4 22.1 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit 6PGD PF00393.19 EGD98459.1 - 2.2e-113 378.4 0.0 6.4e-73 245.6 0.0 2.1 1 1 1 2 2 2 2 6-phosphogluconate dehydrogenase, C-terminal domain NAD_binding_2 PF03446.15 EGD98459.1 - 7e-50 169.3 0.0 1e-49 168.8 0.0 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Shikimate_DH PF01488.20 EGD98459.1 - 0.05 13.7 0.1 0.094 12.8 0.1 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase NAD_binding_11 PF14833.6 EGD98459.1 - 0.093 13.0 0.0 0.33 11.2 0.0 1.9 2 0 0 2 2 2 0 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase Esterase_phd PF10503.9 EGD98459.1 - 0.14 11.7 0.0 0.23 10.9 0.0 1.2 1 0 0 1 1 1 0 Esterase PHB depolymerase Peptidase_C15 PF01470.17 EGD98460.1 - 5.7e-13 49.5 0.0 2.1e-06 28.1 0.0 2.3 2 1 0 2 2 2 2 Pyroglutamyl peptidase AA_permease PF00324.21 EGD98465.1 - 1.7e-113 379.7 37.6 2.2e-113 379.4 37.6 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EGD98465.1 - 2.4e-28 99.1 40.2 2.9e-28 98.9 40.2 1.0 1 0 0 1 1 1 1 Amino acid permease HET PF06985.11 EGD98466.1 - 2.3e-26 92.9 0.6 1e-21 77.9 0.4 2.5 2 0 0 2 2 2 2 Heterokaryon incompatibility protein (HET) Ank_2 PF12796.7 EGD98466.1 - 9e-08 32.6 0.0 4.1e-07 30.5 0.0 2.0 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EGD98466.1 - 3.5e-07 30.4 0.1 7.1e-07 29.4 0.1 1.6 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 EGD98466.1 - 6.5e-07 29.8 0.0 0.0011 19.4 0.0 2.6 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EGD98466.1 - 5.3e-05 23.3 0.0 0.15 12.7 0.0 3.0 2 0 0 2 2 2 2 Ankyrin repeat Ank PF00023.30 EGD98466.1 - 0.00018 21.8 0.0 0.8 10.3 0.0 3.0 3 0 0 3 3 3 2 Ankyrin repeat AP_endonuc_2 PF01261.24 EGD98467.1 - 3.5e-28 98.5 0.0 9e-28 97.1 0.0 1.6 1 1 1 2 2 2 1 Xylose isomerase-like TIM barrel SPT2 PF08243.11 EGD98467.1 - 0.009 16.5 4.6 0.009 16.5 4.6 2.0 2 0 0 2 2 2 1 SPT2 chromatin protein Mad3_BUB1_I PF08311.12 EGD98468.1 - 3.7e-44 149.7 0.4 7.8e-44 148.6 0.1 1.7 2 0 0 2 2 2 1 Mad3/BUB1 homology region 1 Mad3_BUB1_II PF08171.11 EGD98468.1 - 3.1e-16 59.3 0.0 3.1e-15 56.1 0.0 2.7 3 1 0 3 3 3 1 Mad3/BUB1 homology region 2 Pkinase PF00069.25 EGD98468.1 - 6.7e-12 45.3 0.0 1.2e-10 41.2 0.0 2.5 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD98468.1 - 0.00081 18.7 0.0 0.0029 16.9 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase Mad3_BUB1_I_2 PF17014.5 EGD98468.1 - 0.0038 17.3 0.0 0.009 16.1 0.0 1.6 1 0 0 1 1 1 1 Putative Mad3/BUB1 like region 1 protein APH PF01636.23 EGD98468.1 - 0.075 12.9 0.1 0.29 11.0 0.0 1.9 2 0 0 2 2 2 0 Phosphotransferase enzyme family SDA1 PF05285.12 EGD98469.1 - 0.0051 16.3 3.5 0.0055 16.2 3.5 1.1 1 0 0 1 1 1 1 SDA1 DUF4379 PF14311.6 EGD98469.1 - 0.011 16.1 3.5 0.028 14.8 3.5 1.6 1 0 0 1 1 1 0 Probable Zinc-ribbon domain CDC45 PF02724.14 EGD98469.1 - 0.45 8.8 2.8 0.48 8.7 2.8 1.0 1 0 0 1 1 1 0 CDC45-like protein Med13_C PF06333.12 EGD98469.1 - 0.69 9.1 3.9 0.88 8.8 3.9 1.1 1 0 0 1 1 1 0 Mediator complex subunit 13 C-terminal domain Hexokinase_1 PF00349.21 EGD98470.1 - 1.9e-58 197.6 0.0 2.6e-58 197.2 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Hexokinase_2 PF03727.16 EGD98470.1 - 1.3e-44 152.5 0.0 1.9e-44 151.9 0.0 1.2 1 0 0 1 1 1 1 Hexokinase DUF3237 PF11578.8 EGD98471.1 - 2.7e-10 40.3 0.0 3.2e-10 40.0 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3237) ADH_N PF08240.12 EGD98472.1 - 8.6e-21 73.9 1.7 1.6e-20 73.0 1.7 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EGD98472.1 - 1.9e-05 24.6 0.0 4.3e-05 23.5 0.0 1.6 1 1 0 1 1 1 1 Zinc-binding dehydrogenase Fungal_trans PF04082.18 EGD98474.1 - 1.6e-10 40.5 0.4 3e-10 39.6 0.4 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EGD98474.1 - 2.3e-09 37.2 9.5 4.7e-09 36.2 9.5 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Mur_ligase_M PF08245.12 EGD98475.1 - 2.5e-09 37.4 0.3 2.5e-07 30.9 0.1 2.6 2 1 0 2 2 2 2 Mur ligase middle domain Arg_decarb_HB PF17810.1 EGD98475.1 - 0.12 12.6 0.0 1.3 9.4 0.0 2.5 2 0 0 2 2 2 0 Arginine decarboxylase helical bundle domain TPR_7 PF13176.6 EGD98476.1 - 4.9e-11 41.9 0.2 0.0061 16.5 0.1 4.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.6 EGD98476.1 - 3.7e-09 36.7 3.2 0.00032 20.9 0.0 4.7 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 EGD98476.1 - 6.6e-09 35.2 1.3 0.089 13.0 0.1 5.7 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_14 PF13428.6 EGD98476.1 - 1.8e-08 34.5 0.2 2 9.5 0.0 5.6 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_19 PF14559.6 EGD98476.1 - 6.3e-08 33.0 0.0 0.0085 16.6 0.0 3.9 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 EGD98476.1 - 3e-06 27.0 5.0 2.5 8.5 0.0 4.6 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_MalT PF17874.1 EGD98476.1 - 4e-06 26.5 0.9 8.4e-06 25.4 0.1 1.9 2 1 0 2 2 2 1 MalT-like TPR region DUF676 PF05057.14 EGD98476.1 - 4.4e-05 23.1 0.0 8.7e-05 22.1 0.0 1.4 1 0 0 1 1 1 1 Putative serine esterase (DUF676) TPR_1 PF00515.28 EGD98476.1 - 0.00025 20.7 0.7 0.74 9.7 0.1 3.5 4 0 0 4 4 4 2 Tetratricopeptide repeat AAA_22 PF13401.6 EGD98476.1 - 0.0017 18.7 0.0 0.0044 17.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain TPR_10 PF13374.6 EGD98476.1 - 0.0019 18.0 0.0 0.3 11.0 0.0 3.8 4 0 0 4 4 3 1 Tetratricopeptide repeat PGAP1 PF07819.13 EGD98476.1 - 0.0022 17.7 0.0 0.0048 16.7 0.0 1.5 1 0 0 1 1 1 1 PGAP1-like protein AAA_16 PF13191.6 EGD98476.1 - 0.014 15.7 0.0 0.05 14.0 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain Abhydrolase_6 PF12697.7 EGD98476.1 - 0.066 13.8 0.0 0.15 12.7 0.0 1.6 1 0 0 1 1 1 0 Alpha/beta hydrolase family ANAPC3 PF12895.7 EGD98476.1 - 0.071 13.3 0.2 2.7 8.3 0.0 3.3 2 2 1 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 PPR PF01535.20 EGD98476.1 - 0.38 11.1 4.4 51 4.4 0.0 4.5 5 0 0 5 5 5 0 PPR repeat zf-UBR PF02207.20 EGD98477.1 - 6.9e-16 58.2 19.4 6.9e-16 58.2 19.4 2.4 2 0 0 2 2 2 1 Putative zinc finger in N-recognin (UBR box) ClpS PF02617.17 EGD98477.1 - 7.4e-05 22.5 0.0 0.0002 21.1 0.0 1.7 1 0 0 1 1 1 1 ATP-dependent Clp protease adaptor protein ClpS zf-RING_2 PF13639.6 EGD98477.1 - 0.016 15.5 1.0 0.016 15.5 1.0 4.1 3 0 0 3 3 3 0 Ring finger domain ELL PF10390.9 EGD98477.1 - 0.09 12.3 0.0 0.16 11.4 0.0 1.3 1 0 0 1 1 1 0 RNA polymerase II elongation factor ELL UCR_UQCRX_QCR9 PF05365.12 EGD98478.1 - 1.7e-26 91.9 1.2 1.9e-26 91.7 1.2 1.0 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like Mago-bind PF09282.10 EGD98479.1 - 3.2e-14 52.5 2.6 5.8e-14 51.6 2.6 1.4 1 0 0 1 1 1 1 Mago binding SprA-related PF12118.8 EGD98479.1 - 0.0054 15.9 2.1 0.0065 15.6 2.1 1.1 1 0 0 1 1 1 1 SprA-related family Amino_oxidase PF01593.24 EGD98480.1 - 3.8e-30 105.6 0.0 4.5e-30 105.3 0.0 1.1 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EGD98480.1 - 2.1e-14 53.5 0.1 7.7e-14 51.7 0.1 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EGD98480.1 - 3.8e-09 36.6 0.2 4e-08 33.2 0.1 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EGD98480.1 - 0.0001 21.6 0.0 0.0007 18.9 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EGD98480.1 - 0.00031 20.2 0.4 0.0005 19.5 0.4 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.14 EGD98480.1 - 0.0013 17.5 0.1 0.0063 15.3 0.0 1.8 2 0 0 2 2 2 1 HI0933-like protein NAD_binding_9 PF13454.6 EGD98480.1 - 0.0017 18.4 0.1 0.0058 16.6 0.1 1.9 2 0 0 2 2 2 1 FAD-NAD(P)-binding FAD_binding_2 PF00890.24 EGD98480.1 - 0.0017 17.5 0.1 0.0033 16.6 0.1 1.4 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.17 EGD98480.1 - 0.0018 17.6 0.0 0.0033 16.7 0.0 1.3 1 0 0 1 1 1 1 Thi4 family Pyr_redox PF00070.27 EGD98480.1 - 0.0049 17.4 0.1 0.57 10.8 0.1 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.19 EGD98480.1 - 0.043 12.2 0.4 0.13 10.6 0.0 1.8 2 0 0 2 2 2 0 Flavin-binding monooxygenase-like GIDA PF01134.22 EGD98480.1 - 0.16 11.0 0.1 0.9 8.5 0.1 1.9 2 0 0 2 2 2 0 Glucose inhibited division protein A zf-CCCH_2 PF14608.6 EGD98481.1 - 1.9e-11 44.0 54.0 1.5e-06 28.5 10.1 5.5 5 0 0 5 5 5 4 RNA-binding, Nab2-type zinc finger Nab2 PF11517.8 EGD98481.1 - 0.013 15.7 0.1 0.037 14.3 0.1 1.8 1 1 0 1 1 1 0 Nuclear abundant poly(A) RNA-bind protein 2 (Nab2) Glyco_hydro_20 PF00728.22 EGD98482.1 - 1.8e-74 251.3 0.0 2.6e-74 250.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Glycohydro_20b2 PF14845.6 EGD98482.1 - 2e-25 90.1 0.0 1.6e-24 87.1 0.0 2.2 2 0 0 2 2 2 1 beta-acetyl hexosaminidase like Glyco_hydro_20b PF02838.15 EGD98482.1 - 0.0005 20.8 0.0 0.0013 19.5 0.0 1.7 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, domain 2 p450 PF00067.22 EGD98483.1 - 1.3e-59 202.1 0.0 5e-43 147.5 0.0 2.0 2 0 0 2 2 2 2 Cytochrome P450 2-Hacid_dh_C PF02826.19 EGD98485.1 - 1.5e-46 158.0 0.0 2.4e-46 157.4 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EGD98485.1 - 3e-37 127.3 0.1 4.7e-37 126.6 0.1 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain XdhC_C PF13478.6 EGD98485.1 - 0.0031 18.0 0.0 0.0081 16.7 0.0 1.7 1 0 0 1 1 1 1 XdhC Rossmann domain AlaDh_PNT_C PF01262.21 EGD98485.1 - 0.004 16.5 4.1 0.15 11.4 4.1 2.4 1 1 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain ACT PF01842.25 EGD98485.1 - 0.01 15.6 0.6 0.078 12.8 0.0 2.7 3 0 0 3 3 3 0 ACT domain F420_oxidored PF03807.17 EGD98485.1 - 0.1 13.2 0.6 14 6.4 0.0 2.7 2 1 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent Fe-ADH PF00465.19 EGD98486.1 - 1.9e-103 346.1 0.0 2.5e-103 345.7 0.0 1.1 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.6 EGD98486.1 - 3.3e-16 59.8 0.0 5.6e-12 45.9 0.0 2.3 2 0 0 2 2 2 2 Iron-containing alcohol dehydrogenase Peripla_BP_6 PF13458.6 EGD98486.1 - 0.0086 15.8 0.1 0.015 15.0 0.1 1.3 1 0 0 1 1 1 1 Periplasmic binding protein Ank_2 PF12796.7 EGD98487.1 - 1.3e-72 240.4 14.8 3.7e-15 56.3 0.3 7.0 1 1 6 7 7 7 7 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EGD98487.1 - 3e-65 215.8 13.8 9.2e-13 48.4 0.1 8.6 5 2 4 9 9 9 8 Ankyrin repeats (many copies) Ank_3 PF13606.6 EGD98487.1 - 1.2e-54 175.9 12.0 1.9e-05 24.7 0.0 12.1 12 0 0 12 12 12 11 Ankyrin repeat Ank PF00023.30 EGD98487.1 - 5.7e-51 168.9 15.8 1.6e-06 28.3 0.0 11.9 12 0 0 12 12 12 11 Ankyrin repeat Ank_5 PF13857.6 EGD98487.1 - 1.4e-45 152.7 16.4 1.3e-07 31.8 0.0 9.6 5 2 5 10 10 10 9 Ankyrin repeats (many copies) Ig_GlcNase PF18368.1 EGD98488.1 - 3.8e-36 123.4 0.8 2.8e-35 120.6 0.3 2.4 2 0 0 2 2 2 1 Exo-beta-D-glucosaminidase Ig-fold domain Glyco_hydro_2 PF00703.21 EGD98488.1 - 4.4e-10 40.2 0.1 7.2e-09 36.3 0.0 2.7 2 0 0 2 2 2 1 Glycosyl hydrolases family 2 Glyco_hydro_2_N PF02837.18 EGD98488.1 - 1.4e-07 31.6 0.2 3.4e-07 30.3 0.0 1.8 2 0 0 2 2 2 1 Glycosyl hydrolases family 2, sugar binding domain Mannosidase_ig PF17786.1 EGD98488.1 - 4.5e-05 24.0 0.1 0.00055 20.5 0.0 2.4 2 0 0 2 2 2 1 Mannosidase Ig/CBM-like domain Ig_mannosidase PF17753.1 EGD98488.1 - 0.041 13.6 0.1 0.37 10.6 0.0 2.4 2 0 0 2 2 2 0 Ig-fold domain CARDB PF07705.11 EGD98488.1 - 0.077 13.3 0.2 0.26 11.5 0.1 2.0 2 0 0 2 2 2 0 CARDB Glyco_hydro_2_C PF02836.17 EGD98488.1 - 0.11 11.6 0.0 0.21 10.6 0.0 1.4 1 0 0 1 1 1 0 Glycosyl hydrolases family 2, TIM barrel domain DNA_circ_N PF07157.12 EGD98488.1 - 0.16 12.4 0.0 48 4.5 0.0 3.2 3 0 0 3 3 3 0 DNA circularisation protein N-terminus Kin17_mid PF10357.9 EGD98489.1 - 7.4e-48 161.6 1.6 1.6e-47 160.5 1.6 1.5 1 0 0 1 1 1 1 Domain of Kin17 curved DNA-binding protein zf-met PF12874.7 EGD98489.1 - 1.2e-05 25.5 0.9 2.9e-05 24.3 0.9 1.7 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EGD98489.1 - 6.4e-05 23.1 0.3 6.4e-05 23.1 0.3 1.9 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 EGD98489.1 - 0.011 16.0 3.2 0.016 15.5 0.5 2.2 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) Hydin_ADK PF17213.3 EGD98489.1 - 5.3 7.3 6.2 1.8 8.8 3.5 1.5 2 0 0 2 2 2 0 Hydin Adenylate kinase-like domain Glyoxalase PF00903.25 EGD98490.1 - 2.3e-37 128.0 0.1 3.7e-18 65.9 0.1 2.1 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 EGD98490.1 - 4.3e-16 59.1 0.0 3e-06 27.5 0.0 3.8 1 1 3 4 4 4 4 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_6 PF18029.1 EGD98490.1 - 3.6e-07 30.9 0.0 0.0023 18.7 0.0 3.1 2 2 0 2 2 2 2 Glyoxalase-like domain Glyoxalase_3 PF13468.6 EGD98490.1 - 1.1e-06 28.9 0.0 0.02 15.0 0.0 2.9 2 1 0 2 2 2 2 Glyoxalase-like domain Glyoxalase_2 PF12681.7 EGD98490.1 - 0.023 14.6 0.1 4.7 7.2 0.0 3.6 4 1 0 4 4 4 0 Glyoxalase-like domain CppA_N PF14506.6 EGD98490.1 - 0.05 13.7 0.0 0.26 11.4 0.0 2.0 2 0 0 2 2 2 0 CppA N-terminal Apolipoprotein PF01442.18 EGD98492.1 - 0.29 11.0 1.0 0.57 10.0 0.6 1.6 2 0 0 2 2 2 0 Apolipoprotein A1/A4/E domain Arrestin_C PF02752.22 EGD98493.1 - 4.4e-18 66.0 0.0 8.6e-18 65.1 0.0 1.5 1 0 0 1 1 1 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 EGD98493.1 - 6.6e-10 39.2 0.0 3.2e-09 37.0 0.0 1.9 2 0 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain Hexapep PF00132.24 EGD98495.1 - 1.8e-06 27.5 11.2 4.9e-05 22.9 2.9 4.6 3 1 1 4 4 4 2 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 EGD98495.1 - 0.0063 16.2 0.4 0.0063 16.2 0.4 2.7 2 1 1 3 3 3 2 Hexapeptide repeat of succinyl-transferase An_peroxidase PF03098.15 EGD98496.1 - 1.3e-41 142.8 0.0 7.1e-28 97.5 0.0 3.2 1 1 1 2 2 2 2 Animal haem peroxidase p450 PF00067.22 EGD98496.1 - 2.7e-08 33.0 0.0 1.2e-05 24.2 0.0 2.2 2 0 0 2 2 2 2 Cytochrome P450 DUF2235 PF09994.9 EGD98497.1 - 7e-99 330.8 0.0 8.9e-99 330.5 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) Glyco_hydro_61 PF03443.14 EGD98498.1 - 0.0069 16.3 0.0 0.03 14.3 0.0 1.9 1 1 1 2 2 2 1 Glycosyl hydrolase family 61 MARVEL PF01284.23 EGD98499.1 - 0.00012 22.1 12.4 0.00023 21.2 12.4 1.4 1 1 0 1 1 1 1 Membrane-associating domain TMEM156 PF15106.6 EGD98499.1 - 0.18 11.2 0.0 0.28 10.6 0.0 1.2 1 0 0 1 1 1 0 TMEM156 protein family PGA2 PF07543.12 EGD98500.1 - 2.6e-44 150.6 1.4 3e-44 150.4 1.4 1.0 1 0 0 1 1 1 1 Protein trafficking PGA2 CCD PF07860.11 EGD98500.1 - 0.0089 16.1 0.2 0.041 13.9 0.0 1.9 1 1 1 2 2 2 1 WisP family C-Terminal Region CENP-S PF15630.6 EGD98501.1 - 1.4e-30 105.5 0.0 1.7e-30 105.2 0.0 1.1 1 0 0 1 1 1 1 CENP-S protein CENP-T_C PF15511.6 EGD98501.1 - 1.3e-10 41.4 0.0 1.4e-10 41.2 0.0 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold Bromo_TP PF07524.13 EGD98501.1 - 0.017 15.1 0.0 0.03 14.3 0.0 1.5 1 1 0 1 1 1 0 Bromodomain associated MMS1_N PF10433.9 EGD98502.1 - 2.5e-123 412.3 0.0 6.6e-123 410.9 0.0 1.7 2 0 0 2 2 2 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.15 EGD98502.1 - 1.4e-61 208.6 0.1 5.6e-61 206.6 0.0 2.0 2 0 0 2 2 2 1 CPSF A subunit region PQQ_3 PF13570.6 EGD98502.1 - 0.68 10.5 2.7 8.3 7.0 0.2 4.2 5 0 0 5 5 5 0 PQQ-like domain NAD_binding_2 PF03446.15 EGD98503.1 - 1.8e-35 122.4 0.0 2.8e-35 121.8 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 EGD98503.1 - 8.4e-27 93.8 0.0 1.3e-26 93.2 0.0 1.3 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase F420_oxidored PF03807.17 EGD98503.1 - 1.5e-06 28.6 0.0 4.7e-06 27.1 0.0 1.8 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent 2-Hacid_dh_C PF02826.19 EGD98503.1 - 0.00024 20.5 0.0 0.00038 19.9 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain GFO_IDH_MocA PF01408.22 EGD98503.1 - 0.0012 19.6 0.0 0.0025 18.7 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold ABC_membrane PF00664.23 EGD98504.1 - 4.2e-86 289.0 39.5 1.7e-44 152.5 16.7 2.3 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EGD98504.1 - 2.3e-63 212.8 0.0 4e-33 114.8 0.0 3.3 2 1 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EGD98504.1 - 4.4e-16 59.0 4.2 4.1e-06 26.4 0.9 4.2 2 2 0 2 2 2 2 RecF/RecN/SMC N terminal domain Rad17 PF03215.15 EGD98504.1 - 1.8e-08 34.5 0.1 0.0016 18.4 0.0 2.6 2 0 0 2 2 2 2 Rad17 P-loop domain AAA_16 PF13191.6 EGD98504.1 - 6.4e-08 33.2 0.3 0.0063 16.9 0.1 3.4 3 1 0 3 3 3 2 AAA ATPase domain AAA_15 PF13175.6 EGD98504.1 - 1.3e-07 31.7 1.5 0.00099 18.9 0.1 3.0 3 0 0 3 3 3 2 AAA ATPase domain AAA_22 PF13401.6 EGD98504.1 - 1.8e-07 31.5 4.6 0.0085 16.4 0.0 4.0 4 1 0 4 4 3 2 AAA domain RsgA_GTPase PF03193.16 EGD98504.1 - 3.9e-07 30.1 0.0 0.0086 16.0 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase AAA_21 PF13304.6 EGD98504.1 - 4.2e-07 30.1 0.0 0.035 13.9 0.0 3.5 3 1 1 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA PF00004.29 EGD98504.1 - 1.1e-06 29.1 0.4 0.17 12.3 0.0 4.4 3 1 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 EGD98504.1 - 4.8e-06 26.4 0.1 0.073 12.8 0.0 3.5 3 1 0 3 3 3 2 AAA domain ABC_ATPase PF09818.9 EGD98504.1 - 2.9e-05 23.1 0.4 0.066 12.0 0.0 3.0 3 0 0 3 3 3 2 Predicted ATPase of the ABC class AAA_29 PF13555.6 EGD98504.1 - 3.8e-05 23.3 0.9 0.016 15.0 0.1 2.6 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_18 PF13238.6 EGD98504.1 - 0.00019 22.0 0.1 0.48 11.0 0.1 2.8 2 0 0 2 2 2 2 AAA domain AAA_25 PF13481.6 EGD98504.1 - 0.00021 21.0 1.6 0.14 11.7 0.1 2.8 3 0 0 3 3 3 2 AAA domain AAA_5 PF07728.14 EGD98504.1 - 0.0004 20.4 0.0 2.4 8.1 0.0 3.3 4 0 0 4 4 3 2 AAA domain (dynein-related subfamily) AAA_23 PF13476.6 EGD98504.1 - 0.0014 19.2 12.8 0.0064 17.0 0.0 3.5 3 0 0 3 3 2 1 AAA domain AAA_7 PF12775.7 EGD98504.1 - 0.0034 16.9 0.0 2.2 7.7 0.0 2.4 2 0 0 2 2 2 2 P-loop containing dynein motor region Zeta_toxin PF06414.12 EGD98504.1 - 0.0036 16.6 0.0 0.57 9.4 0.0 2.4 2 0 0 2 2 2 1 Zeta toxin PRK PF00485.18 EGD98504.1 - 0.0038 17.0 0.0 1.6 8.4 0.0 2.4 2 0 0 2 2 2 1 Phosphoribulokinase / Uridine kinase family SbcCD_C PF13558.6 EGD98504.1 - 0.0043 17.3 1.1 1.7 8.9 0.2 3.8 2 2 0 2 2 2 1 Putative exonuclease SbcCD, C subunit AAA_28 PF13521.6 EGD98504.1 - 0.0053 17.0 0.0 3.8 7.7 0.0 2.6 2 0 0 2 2 2 1 AAA domain ATP-synt_ab PF00006.25 EGD98504.1 - 0.0081 15.8 0.3 2.3 7.8 0.2 2.7 2 1 0 2 2 2 1 ATP synthase alpha/beta family, nucleotide-binding domain RNA_helicase PF00910.22 EGD98504.1 - 0.014 15.8 0.0 5.1 7.5 0.0 2.8 2 0 0 2 2 2 0 RNA helicase AAA_24 PF13479.6 EGD98504.1 - 0.02 14.6 0.0 8 6.1 0.0 2.4 2 0 0 2 2 2 0 AAA domain SRP54 PF00448.22 EGD98504.1 - 0.025 14.2 0.0 4.1 7.0 0.0 2.4 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_33 PF13671.6 EGD98504.1 - 0.04 14.1 0.0 4.4 7.5 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_14 PF13173.6 EGD98504.1 - 0.067 13.2 0.2 4.7 7.3 0.0 3.4 4 0 0 4 4 3 0 AAA domain Pterin_4a PF01329.19 EGD98507.1 - 1.8e-19 69.7 0.0 2.2e-19 69.4 0.0 1.1 1 0 0 1 1 1 1 Pterin 4 alpha carbinolamine dehydratase WSC PF01822.19 EGD98508.1 - 2.7e-36 123.6 31.8 1.9e-18 66.4 11.9 2.7 2 0 0 2 2 2 2 WSC domain peroxidase PF00141.23 EGD98508.1 - 2.1e-22 80.0 0.2 4.1e-22 79.0 0.2 1.4 1 0 0 1 1 1 1 Peroxidase Flg_new PF09479.10 EGD98508.1 - 0.025 14.8 3.6 0.19 11.9 0.1 3.5 4 0 0 4 4 4 0 Listeria-Bacteroides repeat domain (List_Bact_rpt) PSI_PSAK PF01241.18 EGD98508.1 - 0.049 13.7 0.0 0.16 12.0 0.0 1.9 2 0 0 2 2 2 0 Photosystem I psaG / psaK Glyco_trans_2_3 PF13632.6 EGD98509.1 - 1.8e-54 184.7 0.8 1.8e-54 184.7 0.8 2.9 2 1 1 3 3 3 1 Glycosyl transferase family group 2 Glycos_transf_2 PF00535.26 EGD98509.1 - 0.0085 15.9 0.0 0.043 13.6 0.0 2.0 2 0 0 2 2 2 1 Glycosyl transferase family 2 Glyco_hydro_16 PF00722.21 EGD98510.1 - 4.9e-18 65.2 0.0 2.5e-17 62.9 0.0 2.1 1 1 1 2 2 2 1 Glycosyl hydrolases family 16 WSC PF01822.19 EGD98511.1 - 8e-48 160.5 45.0 5.6e-18 64.9 10.5 3.3 3 0 0 3 3 3 3 WSC domain Glyoxal_oxid_N PF07250.11 EGD98511.1 - 1.2e-24 86.8 0.0 6.4e-24 84.5 0.0 2.1 3 0 0 3 3 3 1 Glyoxal oxidase N-terminus DUF1929 PF09118.11 EGD98511.1 - 3.2e-21 75.4 0.0 6.1e-21 74.5 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1929) Kelch_2 PF07646.15 EGD98511.1 - 0.044 13.8 0.0 0.45 10.6 0.0 2.8 2 0 0 2 2 2 0 Kelch motif MFS_1 PF07690.16 EGD98512.1 - 6.2e-14 51.7 69.8 9.5e-09 34.6 31.5 2.7 2 1 1 3 3 3 2 Major Facilitator Superfamily TRI12 PF06609.13 EGD98512.1 - 8.5e-05 21.2 27.4 0.00012 20.6 27.4 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) zf-H2C2_2 PF13465.6 EGD98513.1 - 3.1e-07 30.5 12.0 4e-06 27.0 1.4 3.0 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 EGD98513.1 - 1.4e-05 25.5 15.0 0.0044 17.7 5.6 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EGD98513.1 - 0.00013 22.2 4.8 0.021 15.1 1.2 2.5 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.12 EGD98513.1 - 0.00021 21.5 7.7 0.00041 20.6 7.4 1.7 1 1 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2 PF00096.26 EGD98513.1 - 0.0023 18.3 14.5 0.03 14.8 7.1 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-met PF12874.7 EGD98513.1 - 0.057 13.8 5.1 1.1 9.7 0.8 2.6 2 0 0 2 2 2 0 Zinc-finger of C2H2 type Zn_Tnp_IS1595 PF12760.7 EGD98513.1 - 0.25 11.4 1.7 0.48 10.4 1.7 1.5 1 0 0 1 1 1 0 Transposase zinc-ribbon domain zf-C2H2_11 PF16622.5 EGD98513.1 - 2 8.3 6.9 0.97 9.2 0.3 2.4 2 0 0 2 2 2 0 zinc-finger C2H2-type zf-C2HC_2 PF13913.6 EGD98513.1 - 2.5 8.1 9.8 2.2 8.3 1.9 2.3 2 0 0 2 2 2 0 zinc-finger of a C2HC-type APG5 PF04106.12 EGD98514.1 - 5.9e-69 232.1 0.0 6.8e-69 231.9 0.0 1.0 1 0 0 1 1 1 1 Autophagy protein Apg5 SelP_N PF04592.14 EGD98515.1 - 0.56 9.6 15.3 0.76 9.1 15.3 1.1 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Presenilin PF01080.17 EGD98515.1 - 0.99 8.1 3.3 1.1 8.0 3.3 1.1 1 0 0 1 1 1 0 Presenilin Macoilin PF09726.9 EGD98515.1 - 5.2 5.5 13.6 6.4 5.2 13.6 1.1 1 0 0 1 1 1 0 Macoilin family FAM76 PF16046.5 EGD98515.1 - 7.6 5.8 6.1 9.8 5.4 6.1 1.1 1 0 0 1 1 1 0 FAM76 protein MFS_1 PF07690.16 EGD98516.1 - 4.1e-18 65.4 55.3 2.7e-17 62.8 52.1 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Arrestin_N PF00339.29 EGD98519.1 - 3e-15 56.5 0.0 4.9e-14 52.6 0.0 2.7 2 1 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 EGD98519.1 - 5.5e-05 23.6 0.0 0.028 14.9 0.0 3.2 2 1 0 2 2 2 2 Arrestin (or S-antigen), C-terminal domain Helo_like_N PF17111.5 EGD98520.1 - 7.8e-05 22.1 2.4 0.00013 21.4 2.4 1.4 1 0 0 1 1 1 1 Fungal N-terminal domain of STAND proteins SHR3_chaperone PF08229.11 EGD98521.1 - 3.9e-82 273.8 0.0 5.3e-82 273.4 0.0 1.1 1 0 0 1 1 1 1 ER membrane protein SH3 Phage_holin_2_4 PF16082.5 EGD98521.1 - 0.12 12.1 3.4 0.15 11.8 1.6 2.0 2 0 0 2 2 2 0 Bacteriophage holin family, superfamily II-like Peptidase_M28 PF04389.17 EGD98526.1 - 5.2e-34 117.7 0.3 8.2e-34 117.0 0.3 1.3 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.28 EGD98526.1 - 0.00039 20.2 0.0 0.00066 19.4 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 DUF4317 PF14199.6 EGD98526.1 - 0.081 12.1 0.0 0.13 11.4 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4317) Glyco_hydro81C PF17652.1 EGD98527.1 - 1.1e-130 435.9 5.3 8.9e-116 386.9 2.6 2.1 1 1 1 2 2 2 2 Glycosyl hydrolase family 81 C-terminal domain Glyco_hydro_81 PF03639.13 EGD98527.1 - 4.9e-120 400.5 0.2 7e-120 400.0 0.2 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 81 N-terminal domain Utp14 PF04615.13 EGD98529.1 - 8.4e-213 709.1 64.7 8.4e-213 709.1 64.7 2.4 1 1 1 2 2 2 1 Utp14 protein MRP-L27 PF09809.9 EGD98530.1 - 1.6e-12 47.2 0.2 2.1e-12 46.9 0.2 1.2 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L27 HECT PF00632.25 EGD98531.1 - 2.1e-82 277.1 0.0 3.9e-82 276.2 0.0 1.5 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) IQ PF00612.27 EGD98531.1 - 0.0087 15.8 0.2 0.037 13.8 0.2 2.2 1 0 0 1 1 1 1 IQ calmodulin-binding motif RRM_1 PF00076.22 EGD98532.1 - 1e-80 265.5 5.2 4.7e-22 77.6 0.2 5.3 5 0 0 5 5 5 5 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP PF00658.18 EGD98532.1 - 4.1e-27 94.1 0.2 2.2e-26 91.8 0.2 2.3 2 0 0 2 2 2 1 Poly-adenylate binding protein, unique domain RRM_5 PF13893.6 EGD98532.1 - 1.4e-14 53.8 0.0 0.01 15.5 0.0 5.2 2 1 2 5 5 5 5 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EGD98532.1 - 3.5e-07 30.2 0.3 4.3 7.5 0.0 5.5 5 1 0 5 5 5 2 RNA recognition motif RRM_occluded PF16842.5 EGD98532.1 - 4.4e-06 26.5 0.2 0.014 15.3 0.0 3.5 4 0 0 4 4 4 2 Occluded RNA-recognition motif Nup35_RRM_2 PF14605.6 EGD98532.1 - 0.00049 20.0 0.3 33 4.6 0.0 4.8 5 0 0 5 5 5 0 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.11 EGD98532.1 - 0.0047 17.0 15.2 0.14 12.2 2.2 5.1 4 1 1 5 5 5 1 RNA binding motif Limkain-b1 PF11608.8 EGD98532.1 - 0.0079 16.3 1.0 3.6 7.7 0.0 3.6 3 0 0 3 3 3 1 Limkain b1 OB_RNB PF08206.11 EGD98532.1 - 0.075 12.7 2.0 14 5.4 0.0 3.5 3 0 0 3 3 3 0 Ribonuclease B OB domain NPR3 PF03666.13 EGD98532.1 - 0.45 9.3 4.9 0.72 8.6 4.9 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 RNA_pol_Rpc4 PF05132.14 EGD98532.1 - 0.56 10.6 12.0 4.7 7.6 9.2 2.7 2 0 0 2 2 2 0 RNA polymerase III RPC4 Fe-ADH PF00465.19 EGD98533.1 - 2.3e-67 227.4 0.9 2.8e-67 227.1 0.9 1.0 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.6 EGD98533.1 - 1.1e-18 67.8 0.0 2.1e-18 67.0 0.0 1.3 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase DHQ_synthase PF01761.20 EGD98533.1 - 0.011 14.9 0.1 1.5 7.9 0.0 2.3 2 0 0 2 2 2 0 3-dehydroquinate synthase PFK PF00365.20 EGD98533.1 - 0.016 14.5 0.0 0.025 13.9 0.0 1.2 1 0 0 1 1 1 0 Phosphofructokinase Peripla_BP_6 PF13458.6 EGD98533.1 - 0.025 14.2 0.1 0.04 13.6 0.1 1.3 1 0 0 1 1 1 0 Periplasmic binding protein Sigma54_activ_2 PF14532.6 EGD98533.1 - 0.16 12.1 0.0 0.4 10.8 0.0 1.7 2 0 0 2 2 2 0 Sigma-54 interaction domain DAO PF01266.24 EGD98534.1 - 9.5e-41 140.5 1.7 5.4e-28 98.6 0.0 3.0 1 1 1 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EGD98534.1 - 4.5e-05 23.6 0.1 9.1e-05 22.6 0.1 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EGD98534.1 - 0.0052 16.1 0.0 0.011 14.9 0.0 1.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EGD98534.1 - 0.0058 16.6 0.0 0.011 15.8 0.0 1.4 1 0 0 1 1 1 1 FAD-NAD(P)-binding FAD_binding_3 PF01494.19 EGD98534.1 - 0.0074 15.6 0.3 0.031 13.5 0.1 1.8 2 0 0 2 2 2 1 FAD binding domain Thi4 PF01946.17 EGD98534.1 - 0.0088 15.3 0.2 0.024 13.9 0.1 1.7 2 0 0 2 2 2 1 Thi4 family Pyr_redox PF00070.27 EGD98534.1 - 0.011 16.3 0.0 0.021 15.4 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EGD98534.1 - 0.016 14.3 0.0 0.026 13.6 0.0 1.3 1 0 0 1 1 1 0 FAD binding domain FAD_oxidored PF12831.7 EGD98534.1 - 0.024 14.0 3.0 0.039 13.3 3.0 1.5 1 1 0 1 1 1 0 FAD dependent oxidoreductase 3HCDH_N PF02737.18 EGD98534.1 - 0.079 12.8 0.0 0.12 12.2 0.0 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Pyr_redox_3 PF13738.6 EGD98534.1 - 0.085 12.1 0.0 0.33 10.2 0.0 1.8 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Vps52 PF04129.12 EGD98535.1 - 3.2e-123 412.2 2.7 4e-123 411.9 2.7 1.0 1 0 0 1 1 1 1 Vps52 / Sac2 family Sec3_C PF09763.9 EGD98535.1 - 6.8e-07 28.1 4.5 9.9e-07 27.5 4.5 1.2 1 0 0 1 1 1 1 Exocyst complex component Sec3 MitMem_reg PF13012.6 EGD98535.1 - 0.0003 21.2 1.9 0.033 14.6 0.6 3.6 3 1 0 3 3 3 1 Maintenance of mitochondrial structure and function COG2 PF06148.11 EGD98535.1 - 0.031 14.4 1.1 0.071 13.2 0.1 2.1 2 1 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 SecA_SW PF07516.13 EGD98535.1 - 0.048 13.7 0.3 0.41 10.7 0.0 2.3 2 0 0 2 2 2 0 SecA Wing and Scaffold domain Matrilin_ccoil PF10393.9 EGD98535.1 - 0.13 12.1 0.0 0.51 10.2 0.0 2.0 1 0 0 1 1 1 0 Trimeric coiled-coil oligomerisation domain of matrilin eIF-5a PF01287.20 EGD98536.1 - 5.3e-27 93.7 0.6 7.6e-27 93.2 0.6 1.2 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold EFP_N PF08207.12 EGD98536.1 - 0.0037 17.2 0.5 0.02 14.9 0.0 2.1 2 0 0 2 2 2 1 Elongation factor P (EF-P) KOW-like domain zf-RRN7 PF11781.8 EGD98537.1 - 1.9e-06 27.4 6.0 3.5e-06 26.6 6.0 1.4 1 0 0 1 1 1 1 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 Tli4_C PF18426.1 EGD98537.1 - 0.0082 16.5 0.4 0.017 15.5 0.4 1.5 1 0 0 1 1 1 1 Tle cognate immunity protein 4 C-terminal domain Ribosomal_L40e PF01020.17 EGD98538.1 - 3.9e-20 71.5 8.0 7.8e-20 70.5 8.0 1.5 1 1 0 1 1 1 1 Ribosomal L40e family ubiquitin PF00240.23 EGD98538.1 - 1.4e-19 69.6 0.0 1.9e-19 69.2 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 EGD98538.1 - 2.1e-05 24.3 0.0 2.8e-05 23.8 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like AKAP_110 PF05716.13 EGD98538.1 - 0.097 10.9 0.0 0.12 10.6 0.0 1.1 1 0 0 1 1 1 0 A-kinase anchor protein 110 kDa (AKAP 110) Yip1 PF04893.17 EGD98539.1 - 1.5e-15 57.3 17.1 3.1e-15 56.3 17.1 1.5 1 1 0 1 1 1 1 Yip1 domain YIF1 PF03878.15 EGD98539.1 - 0.14 11.7 6.1 0.18 11.3 3.1 2.2 1 1 0 2 2 2 0 YIF1 DUF5585 PF17823.1 EGD98539.1 - 0.33 9.8 0.1 0.47 9.3 0.1 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5585) RabGAP-TBC PF00566.18 EGD98540.1 - 6.5e-23 81.5 0.1 1.6e-22 80.2 0.2 1.6 2 0 0 2 2 2 1 Rab-GTPase-TBC domain MMS1_N PF10433.9 EGD98542.1 - 6.1e-90 302.2 0.0 1.1e-89 301.4 0.0 1.4 1 0 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.15 EGD98542.1 - 0.0018 17.7 0.0 0.0073 15.7 0.0 1.8 2 0 0 2 2 2 1 CPSF A subunit region Lgl_C PF08596.10 EGD98542.1 - 0.17 10.5 0.0 6.2 5.4 0.0 2.7 3 0 0 3 3 3 0 Lethal giant larvae(Lgl) like, C-terminal GTP_EFTU PF00009.27 EGD98543.1 - 3.6e-34 118.0 0.1 5.3e-33 114.2 0.1 2.8 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain IF-2 PF11987.8 EGD98543.1 - 7.2e-21 74.3 0.1 2.2e-20 72.8 0.1 1.8 1 0 0 1 1 1 1 Translation-initiation factor 2 GTP_EFTU_D2 PF03144.25 EGD98543.1 - 7e-10 39.2 4.3 7.9e-10 39.0 0.1 3.1 3 0 0 3 3 3 1 Elongation factor Tu domain 2 GTP_EFTU_D4 PF14578.6 EGD98543.1 - 2.2e-09 37.1 0.0 7.2e-09 35.4 0.0 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 4 MMR_HSR1 PF01926.23 EGD98543.1 - 5.5e-07 29.7 0.5 1e-05 25.5 0.0 3.2 3 0 0 3 3 3 1 50S ribosome-binding GTPase Roc PF08477.13 EGD98543.1 - 0.00056 20.1 0.0 0.0019 18.4 0.0 2.0 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase ATP_bind_1 PF03029.17 EGD98543.1 - 0.0059 16.4 0.0 0.026 14.3 0.0 2.3 1 1 0 1 1 1 1 Conserved hypothetical ATP binding protein Ras PF00071.22 EGD98543.1 - 0.05 13.2 0.0 0.25 10.9 0.0 2.4 1 1 0 1 1 1 0 Ras family Rhodanese PF00581.20 EGD98544.1 - 2.6e-09 37.5 0.0 6.4e-09 36.3 0.0 1.6 2 0 0 2 2 2 1 Rhodanese-like domain p450 PF00067.22 EGD98545.1 - 2.9e-53 181.2 0.0 4.1e-53 180.7 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Glyoxalase_6 PF18029.1 EGD98546.1 - 0.00024 21.9 0.1 0.00045 21.0 0.1 1.4 1 1 0 1 1 1 1 Glyoxalase-like domain Glyoxalase PF00903.25 EGD98546.1 - 0.0047 17.1 0.0 0.048 13.8 0.0 2.0 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily zf-HC2 PF13490.6 EGD98546.1 - 0.15 12.4 0.1 0.33 11.3 0.1 1.6 1 0 0 1 1 1 0 Putative zinc-finger SRP68 PF16969.5 EGD98547.1 - 1.3e-184 615.3 0.4 1.5e-184 615.2 0.4 1.0 1 0 0 1 1 1 1 RNA-binding signal recognition particle 68 CENP-O PF09496.10 EGD98547.1 - 0.19 11.7 1.1 1.8 8.5 0.1 2.9 2 1 1 3 3 3 0 Cenp-O kinetochore centromere component PPR PF01535.20 EGD98548.1 - 1.2e-18 66.0 2.3 5e-05 23.3 0.0 8.5 8 0 0 8 8 8 5 PPR repeat PPR_3 PF13812.6 EGD98548.1 - 4.3e-17 61.9 0.5 3.6e-07 30.1 0.0 5.2 3 2 2 5 5 5 4 Pentatricopeptide repeat domain PPR_2 PF13041.6 EGD98548.1 - 7.8e-17 61.2 6.2 5.1e-09 36.2 0.0 6.6 4 1 3 7 7 7 2 PPR repeat family PPR_long PF17177.4 EGD98548.1 - 7.9e-11 41.7 0.0 3.7e-05 23.2 0.0 3.3 1 1 1 2 2 2 2 Pentacotripeptide-repeat region of PRORP PPR_1 PF12854.7 EGD98548.1 - 7.5e-06 25.5 0.0 2.1 8.1 0.0 5.5 6 0 0 6 6 6 2 PPR repeat MCM PF00493.23 EGD98549.1 - 1e-97 325.7 0.1 1.7e-97 324.9 0.1 1.4 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 EGD98549.1 - 3.3e-31 107.7 0.0 7.4e-31 106.6 0.0 1.6 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 EGD98549.1 - 2.8e-24 85.3 0.8 9.7e-24 83.6 0.6 2.0 2 0 0 2 2 2 1 MCM AAA-lid domain MCM_N PF14551.6 EGD98549.1 - 1.4e-11 44.9 0.0 4.2e-11 43.3 0.0 1.8 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 EGD98549.1 - 1.3e-06 28.0 0.0 1.4e-05 24.5 0.0 2.2 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 EGD98549.1 - 0.003 17.4 0.0 0.0072 16.2 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 EGD98549.1 - 0.1 12.3 0.0 0.25 11.0 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain Spo7 PF03907.13 EGD98550.1 - 1.4e-89 299.4 0.0 2.1e-89 298.8 0.0 1.3 1 0 0 1 1 1 1 Spo7-like protein YL1 PF05764.13 EGD98550.1 - 0.13 12.4 5.8 0.29 11.2 5.8 1.6 1 0 0 1 1 1 0 YL1 nuclear protein Abhydrolase_1 PF00561.20 EGD98551.1 - 1.1e-20 74.3 0.0 3.4e-18 66.2 0.0 2.5 2 1 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EGD98551.1 - 4.1e-16 60.2 0.2 3.8e-15 57.1 0.2 2.2 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EGD98551.1 - 4.6e-16 58.8 0.0 2.5e-15 56.4 0.0 2.0 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Esterase PF00756.20 EGD98551.1 - 7.5e-05 22.5 0.0 0.00017 21.3 0.0 1.6 1 0 0 1 1 1 1 Putative esterase DUF915 PF06028.11 EGD98551.1 - 0.001 18.4 0.0 0.002 17.5 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF915) LIDHydrolase PF10230.9 EGD98551.1 - 0.003 17.1 0.0 0.0061 16.1 0.0 1.4 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase Chlorophyllase2 PF12740.7 EGD98551.1 - 0.0057 15.6 0.0 0.0082 15.1 0.0 1.2 1 0 0 1 1 1 1 Chlorophyllase enzyme Chlorophyllase PF07224.11 EGD98551.1 - 0.0098 14.9 0.0 0.014 14.4 0.0 1.2 1 0 0 1 1 1 1 Chlorophyllase Abhydrolase_3 PF07859.13 EGD98551.1 - 0.017 15.0 0.0 0.073 12.9 0.0 2.0 3 0 0 3 3 3 0 alpha/beta hydrolase fold Abhydrolase_2 PF02230.16 EGD98551.1 - 0.019 14.8 0.0 4.1 7.2 0.0 2.9 3 0 0 3 3 3 0 Phospholipase/Carboxylesterase Thioesterase PF00975.20 EGD98551.1 - 0.025 14.7 0.4 0.2 11.8 0.4 2.3 1 1 0 1 1 1 0 Thioesterase domain Abhydrolase_5 PF12695.7 EGD98551.1 - 0.029 14.1 0.0 0.057 13.2 0.0 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase family Ser_hydrolase PF06821.13 EGD98551.1 - 0.033 14.1 0.0 0.3 10.9 0.0 2.4 3 0 0 3 3 3 0 Serine hydrolase Lipase_3 PF01764.25 EGD98551.1 - 0.046 13.6 0.0 0.084 12.7 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) Peptidase_S9 PF00326.21 EGD98551.1 - 0.088 12.3 0.0 0.38 10.2 0.0 2.0 2 0 0 2 2 2 0 Prolyl oligopeptidase family Herpes_pp85 PF04637.12 EGD98551.1 - 7.2 4.9 5.4 11 4.3 5.4 1.2 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) TatD_DNase PF01026.21 EGD98552.1 - 1.4e-37 129.4 0.0 2.4e-37 128.7 0.0 1.3 1 0 0 1 1 1 1 TatD related DNase TPP_enzyme_N PF02776.18 EGD98553.1 - 5.4e-39 133.5 0.1 3.1e-38 131.1 0.0 2.3 2 1 0 2 2 2 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.21 EGD98553.1 - 6.6e-21 74.7 0.1 1.3e-20 73.8 0.1 1.5 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.22 EGD98553.1 - 1.8e-13 50.4 0.0 2e-12 47.0 0.0 2.4 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain NTP_transf_3 PF12804.7 EGD98553.1 - 0.032 14.6 0.6 1.3 9.4 0.6 3.0 1 1 0 1 1 1 0 MobA-like NTP transferase domain DEK_C PF08766.11 EGD98554.1 - 1.3e-18 66.7 0.6 3.4e-18 65.3 0.4 1.7 2 0 0 2 2 2 1 DEK C terminal domain Chitin_synth_2 PF03142.15 EGD98555.1 - 1.2e-228 760.0 0.1 1.7e-228 759.5 0.1 1.1 1 0 0 1 1 1 1 Chitin synthase Cyt-b5 PF00173.28 EGD98555.1 - 2.1e-16 59.8 0.3 4e-10 39.7 0.0 2.8 2 0 0 2 2 2 2 Cytochrome b5-like Heme/Steroid binding domain Glyco_trans_2_3 PF13632.6 EGD98555.1 - 7e-13 48.9 4.4 1.8e-12 47.6 4.4 1.8 1 0 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 EGD98555.1 - 3.2e-12 46.8 0.0 3.4e-11 43.5 0.0 2.1 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Myosin_head PF00063.21 EGD98555.1 - 2.1e-09 36.2 0.0 2.3e-07 29.4 0.0 2.1 1 1 0 2 2 2 2 Myosin head (motor domain) Glyco_transf_21 PF13506.6 EGD98555.1 - 0.00011 21.7 0.0 0.0069 15.9 0.0 2.4 2 0 0 2 2 2 1 Glycosyl transferase family 21 Glycos_transf_2 PF00535.26 EGD98555.1 - 0.00083 19.2 0.0 0.37 10.6 0.0 2.6 2 0 0 2 2 2 2 Glycosyl transferase family 2 Chitin_synth_2 PF03142.15 EGD98557.1 - 1.6e-246 819.0 0.7 2.3e-246 818.5 0.7 1.2 1 0 0 1 1 1 1 Chitin synthase Myosin_head PF00063.21 EGD98557.1 - 1.1e-72 245.3 0.0 8e-72 242.5 0.0 2.0 1 1 0 1 1 1 1 Myosin head (motor domain) Cyt-b5 PF00173.28 EGD98557.1 - 1.4e-18 66.8 0.5 4e-14 52.5 0.1 3.6 2 1 0 2 2 2 2 Cytochrome b5-like Heme/Steroid binding domain DEK_C PF08766.11 EGD98557.1 - 5e-15 55.2 0.4 1.3e-14 53.9 0.4 1.7 1 0 0 1 1 1 1 DEK C terminal domain Glyco_trans_2_3 PF13632.6 EGD98557.1 - 4.2e-13 49.7 5.0 1.1e-12 48.3 5.0 1.8 1 0 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 EGD98557.1 - 1.2e-10 41.7 0.1 1e-09 38.7 0.1 2.2 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 EGD98557.1 - 0.00026 20.8 0.0 0.074 12.9 0.0 2.6 2 0 0 2 2 2 1 Glycosyl transferase family 2 Glyco_transf_21 PF13506.6 EGD98557.1 - 0.0023 17.4 0.2 0.029 13.8 0.2 2.4 1 1 0 1 1 1 1 Glycosyl transferase family 21 RsgA_GTPase PF03193.16 EGD98557.1 - 0.017 15.0 0.0 0.33 10.9 0.1 2.5 2 0 0 2 2 2 0 RsgA GTPase AAA_16 PF13191.6 EGD98557.1 - 0.056 13.8 0.2 0.23 11.9 0.1 2.0 2 0 0 2 2 2 0 AAA ATPase domain KH_1 PF00013.29 EGD98558.1 - 6.2e-29 99.6 1.1 1.8e-05 24.5 0.1 7.0 7 0 0 7 7 7 5 KH domain Ribosomal_S6 PF01250.17 EGD98558.1 - 0.024 14.9 0.0 0.11 12.7 0.0 2.1 2 0 0 2 2 2 0 Ribosomal protein S6 SUV3_C PF12513.8 EGD98558.1 - 0.14 12.1 0.1 0.41 10.6 0.1 1.9 1 0 0 1 1 1 0 Mitochondrial degradasome RNA helicase subunit C terminal SOG2 PF10428.9 EGD98558.1 - 2.2 7.4 11.0 4.4 6.4 11.0 1.5 1 0 0 1 1 1 0 RAM signalling pathway protein RP-C_C PF11800.8 EGD98558.1 - 7.9 6.5 7.0 16 5.5 7.0 1.4 1 0 0 1 1 1 0 Replication protein C C-terminal region Hydrolase PF00702.26 EGD98559.1 - 4.7e-08 33.6 0.0 6.4e-08 33.1 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 EGD98559.1 - 9.5e-08 32.3 0.0 1.5e-07 31.7 0.0 1.4 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EGD98559.1 - 0.0095 16.0 0.0 0.016 15.2 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like Dynactin PF12455.8 EGD98561.1 - 5.4e-100 334.3 1.8 5.4e-100 334.3 1.8 3.7 3 1 0 3 3 3 1 Dynein associated protein CAP_GLY PF01302.25 EGD98561.1 - 2e-20 72.6 0.1 3.3e-20 71.9 0.1 1.3 1 0 0 1 1 1 1 CAP-Gly domain APG6_N PF17675.1 EGD98561.1 - 0.051 14.1 0.1 0.051 14.1 0.1 8.3 5 2 4 9 9 9 0 Apg6 coiled-coil region HALZ PF02183.18 EGD98561.1 - 0.21 11.9 0.1 0.21 11.9 0.1 7.6 6 1 2 8 8 8 0 Homeobox associated leucine zipper Beta_elim_lyase PF01212.21 EGD98562.1 - 6.2e-85 285.0 0.0 7.5e-85 284.8 0.0 1.0 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_1_2 PF00155.21 EGD98562.1 - 5.4e-08 32.4 0.0 7.9e-08 31.9 0.0 1.3 1 1 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 EGD98562.1 - 7.8e-06 25.1 0.0 1.4e-05 24.3 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 EGD98562.1 - 0.008 14.7 0.1 0.015 13.9 0.0 1.5 2 0 0 2 2 2 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 EGD98562.1 - 0.028 13.7 0.0 0.34 10.2 0.0 2.2 2 0 0 2 2 2 0 DegT/DnrJ/EryC1/StrS aminotransferase family OKR_DC_1 PF01276.20 EGD98562.1 - 0.039 12.7 0.0 0.059 12.1 0.0 1.2 1 0 0 1 1 1 0 Orn/Lys/Arg decarboxylase, major domain Solute_trans_a PF03619.16 EGD98564.1 - 6.2e-92 307.9 9.9 8.2e-92 307.5 9.9 1.1 1 0 0 1 1 1 1 Organic solute transporter Ostalpha Podoplanin PF05808.11 EGD98564.1 - 0.94 9.6 2.3 1.7 8.7 2.3 1.4 1 0 0 1 1 1 0 Podoplanin Glyco_hyd_65N_2 PF14498.6 EGD98565.1 - 0.049 13.5 0.0 0.092 12.6 0.0 1.4 1 0 0 1 1 1 0 Glycosyl hydrolase family 65, N-terminal domain GTP_EFTU PF00009.27 EGD98566.1 - 3.5e-67 225.7 0.2 4.8e-67 225.3 0.2 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 EGD98566.1 - 5e-30 103.8 0.0 3e-29 101.3 0.0 2.1 2 0 0 2 2 2 1 Elongation factor G, domain IV EFG_C PF00679.24 EGD98566.1 - 2.5e-21 75.5 0.0 9.2e-21 73.7 0.0 2.0 2 0 0 2 2 2 1 Elongation factor G C-terminus EFG_II PF14492.6 EGD98566.1 - 4.5e-12 45.9 0.0 1.4e-11 44.4 0.0 1.8 1 0 0 1 1 1 1 Elongation Factor G, domain II MMR_HSR1 PF01926.23 EGD98566.1 - 8.6e-05 22.6 0.1 0.00021 21.3 0.1 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D2 PF03144.25 EGD98566.1 - 0.008 16.5 0.0 0.035 14.5 0.0 2.2 2 0 0 2 2 2 1 Elongation factor Tu domain 2 PWI PF01480.17 EGD98567.1 - 6.6e-10 39.2 0.1 1.4e-09 38.1 0.1 1.5 1 0 0 1 1 1 1 PWI domain RRM_1 PF00076.22 EGD98567.1 - 1.3e-07 31.3 0.1 2e-05 24.3 0.1 2.6 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EGD98567.1 - 2.3e-06 27.5 0.0 7e-05 22.8 0.1 2.4 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif zf-CCCH PF00642.24 EGD98567.1 - 0.00051 19.9 1.1 0.00088 19.1 1.1 1.4 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 EGD98567.1 - 0.013 15.5 1.4 0.024 14.7 1.4 1.4 1 0 0 1 1 1 0 Zinc finger domain RRM_occluded PF16842.5 EGD98567.1 - 0.016 15.0 0.0 0.23 11.4 0.0 2.4 2 0 0 2 2 2 0 Occluded RNA-recognition motif UPF0242 PF06785.11 EGD98567.1 - 0.21 11.7 5.5 0.36 10.9 5.5 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus TipAS PF07739.13 EGD98567.1 - 1.5 9.4 8.3 13 6.4 0.1 2.6 2 1 0 2 2 2 0 TipAS antibiotic-recognition domain RRM_3 PF08777.11 EGD98567.1 - 7.3 6.7 9.6 2.1 8.4 0.1 2.9 3 0 0 3 3 3 0 RNA binding motif adh_short PF00106.25 EGD98568.1 - 1.4e-17 63.8 0.0 1.9e-17 63.3 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EGD98568.1 - 3.2e-12 46.5 0.0 4.7e-12 46.0 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase MFS_1 PF07690.16 EGD98569.1 - 1.6e-41 142.4 16.0 5.1e-41 140.8 16.8 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EGD98569.1 - 5.4e-10 38.7 11.9 1e-09 37.8 11.8 1.4 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_4 PF06779.14 EGD98569.1 - 1.4e-05 24.6 13.0 0.0006 19.2 13.0 2.1 1 1 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB MFS_1_like PF12832.7 EGD98569.1 - 0.00013 20.9 5.9 0.00013 20.9 5.9 1.6 1 1 0 1 1 1 1 MFS_1 like family DctQ PF04290.12 EGD98569.1 - 0.004 17.1 0.0 0.004 17.1 0.0 2.8 2 2 0 2 2 2 1 Tripartite ATP-independent periplasmic transporters, DctQ component DUF4131 PF13567.6 EGD98569.1 - 0.007 16.0 2.4 2.7 7.6 0.0 3.0 3 0 0 3 3 3 2 Domain of unknown function (DUF4131) CitMHS PF03600.16 EGD98569.1 - 0.14 11.3 17.8 1 8.5 8.7 2.2 1 1 1 2 2 2 0 Citrate transporter RIBIOP_C PF04950.12 EGD98571.1 - 7e-96 321.1 0.0 7e-96 321.1 0.0 1.9 2 0 0 2 2 1 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal AARP2CN PF08142.12 EGD98571.1 - 9.4e-29 99.3 0.0 2.4e-28 98.0 0.0 1.8 1 0 0 1 1 1 1 AARP2CN (NUC121) domain AAA_22 PF13401.6 EGD98571.1 - 3.4e-05 24.1 0.2 9.6e-05 22.7 0.0 1.9 2 0 0 2 2 1 1 AAA domain GTP_EFTU PF00009.27 EGD98571.1 - 6.3e-05 22.6 0.0 0.0092 15.5 0.0 2.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA PF00004.29 EGD98571.1 - 0.00018 21.9 0.0 0.00044 20.7 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EGD98571.1 - 0.00024 21.5 0.0 0.0007 20.0 0.0 1.8 1 0 0 1 1 1 1 AAA ATPase domain MMR_HSR1 PF01926.23 EGD98571.1 - 0.0013 18.8 0.0 0.0041 17.2 0.0 1.9 1 0 0 1 1 1 1 50S ribosome-binding GTPase NB-ARC PF00931.22 EGD98571.1 - 0.0026 17.0 0.0 0.0061 15.8 0.0 1.5 1 0 0 1 1 1 1 NB-ARC domain AAA_7 PF12775.7 EGD98571.1 - 0.004 16.7 0.0 0.0078 15.7 0.0 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region PduV-EutP PF10662.9 EGD98571.1 - 0.0052 16.5 0.0 0.024 14.4 0.0 1.9 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation cobW PF02492.19 EGD98571.1 - 0.0081 15.8 0.0 0.016 14.8 0.0 1.4 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain RNA_helicase PF00910.22 EGD98571.1 - 0.0084 16.5 0.0 0.021 15.2 0.0 1.7 1 0 0 1 1 1 1 RNA helicase NTPase_1 PF03266.15 EGD98571.1 - 0.016 15.1 0.4 0.031 14.2 0.4 1.4 1 0 0 1 1 1 0 NTPase KCNQC3-Ank-G_bd PF11956.8 EGD98571.1 - 0.017 15.4 0.6 0.017 15.4 0.6 2.2 2 0 0 2 2 1 0 Ankyrin-G binding motif of KCNQ2-3 ABC_tran PF00005.27 EGD98571.1 - 0.02 15.4 1.7 0.033 14.7 0.1 2.2 2 0 0 2 2 1 0 ABC transporter AAA_33 PF13671.6 EGD98571.1 - 0.031 14.4 0.0 0.031 14.4 0.0 2.3 2 0 0 2 2 1 0 AAA domain AAA_18 PF13238.6 EGD98571.1 - 0.034 14.7 0.2 0.034 14.7 0.2 3.3 4 0 0 4 4 2 0 AAA domain AAA_19 PF13245.6 EGD98571.1 - 0.042 14.2 0.2 0.093 13.1 0.2 1.5 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 EGD98571.1 - 0.043 13.7 0.0 0.092 12.7 0.0 1.6 1 0 0 1 1 1 0 NACHT domain AAA_14 PF13173.6 EGD98571.1 - 0.046 13.8 0.0 0.12 12.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 EGD98571.1 - 0.05 13.5 1.3 0.073 13.0 0.0 1.9 2 0 0 2 2 1 0 ATPase domain predominantly from Archaea Roc PF08477.13 EGD98571.1 - 0.055 13.7 0.1 0.16 12.2 0.1 1.8 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_5 PF07728.14 EGD98571.1 - 0.059 13.4 0.2 0.19 11.7 0.1 2.0 2 0 0 2 2 1 0 AAA domain (dynein-related subfamily) AAA_30 PF13604.6 EGD98571.1 - 0.062 13.0 0.0 0.12 12.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain KAP_NTPase PF07693.14 EGD98571.1 - 0.075 12.3 0.0 0.13 11.4 0.0 1.3 1 0 0 1 1 1 0 KAP family P-loop domain Rad17 PF03215.15 EGD98571.1 - 0.085 12.8 0.0 0.19 11.7 0.0 1.5 1 0 0 1 1 1 0 Rad17 P-loop domain MobB PF03205.14 EGD98571.1 - 0.09 12.7 0.1 0.42 10.5 0.1 2.1 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B RsgA_GTPase PF03193.16 EGD98571.1 - 0.1 12.5 0.1 0.36 10.7 0.1 1.8 1 1 1 2 2 2 0 RsgA GTPase ATP_bind_1 PF03029.17 EGD98571.1 - 0.15 11.9 0.1 0.26 11.0 0.1 1.3 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein Viral_helicase1 PF01443.18 EGD98571.1 - 0.16 11.7 0.1 0.3 10.8 0.1 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_11 PF13086.6 EGD98571.1 - 0.24 11.2 0.0 0.24 11.2 0.0 3.0 3 0 0 3 3 3 0 AAA domain Aminotran_1_2 PF00155.21 EGD98572.1 - 9.5e-39 133.6 0.0 1.3e-38 133.1 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II SDA1 PF05285.12 EGD98574.1 - 0.043 13.2 8.3 0.056 12.9 8.3 1.2 1 0 0 1 1 1 0 SDA1 DUF1989 PF09347.10 EGD98575.1 - 1.5e-53 180.9 0.2 2.9e-53 179.9 0.2 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF1989) Abhydrolase_1 PF00561.20 EGD98576.1 - 8.7e-14 51.8 0.0 1.1e-13 51.4 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EGD98576.1 - 4.9e-11 43.7 0.0 6.3e-11 43.3 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EGD98576.1 - 3.4e-08 33.1 0.0 7.6e-08 31.9 0.0 1.5 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_2 PF02230.16 EGD98576.1 - 0.02 14.7 0.0 12 5.6 0.0 3.1 3 0 0 3 3 3 0 Phospholipase/Carboxylesterase DUF3425 PF11905.8 EGD98577.1 - 1.5e-10 41.1 2.4 7.3e-09 35.7 0.3 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF3425) bZIP_1 PF00170.21 EGD98577.1 - 0.062 13.4 8.8 0.11 12.5 8.8 1.3 1 0 0 1 1 1 0 bZIP transcription factor bZIP_2 PF07716.15 EGD98577.1 - 0.18 11.9 7.0 0.37 10.9 7.0 1.5 1 0 0 1 1 1 0 Basic region leucine zipper BCDHK_Adom3 PF10436.9 EGD98579.1 - 5.1e-46 156.5 0.1 7.5e-46 155.9 0.1 1.3 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 EGD98579.1 - 5.2e-09 36.6 0.0 2.4e-08 34.5 0.0 2.0 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_2 PF13581.6 EGD98579.1 - 0.031 14.2 0.0 0.089 12.8 0.0 1.7 1 1 0 1 1 1 0 Histidine kinase-like ATPase domain Lactamase_B_2 PF12706.7 EGD98580.1 - 1.1e-14 54.4 0.2 2.1e-14 53.5 0.2 1.5 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 EGD98580.1 - 3.4e-10 40.1 1.7 2.4e-09 37.3 1.7 2.1 1 1 0 1 1 1 1 Beta-lactamase superfamily domain ketoacyl-synt PF00109.26 EGD98581.1 - 1.1e-47 162.8 6.1 6.6e-26 91.4 1.3 3.0 2 1 1 3 3 3 2 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 EGD98581.1 - 5.8e-35 119.9 0.4 1.2e-34 118.8 0.4 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Thiolase_N PF00108.23 EGD98581.1 - 4e-06 26.4 2.1 0.00016 21.1 0.6 2.5 2 1 1 3 3 3 2 Thiolase, N-terminal domain Thiolase_C PF02803.18 EGD98581.1 - 0.03 14.0 0.4 0.03 14.0 0.4 2.9 2 2 1 3 3 3 0 Thiolase, C-terminal domain Arginase PF00491.21 EGD98582.1 - 7e-87 291.5 0.2 8.5e-87 291.2 0.2 1.1 1 0 0 1 1 1 1 Arginase family UPF0489 PF12640.7 EGD98582.1 - 0.0032 17.7 0.1 0.0063 16.8 0.1 1.4 1 0 0 1 1 1 1 UPF0489 domain Ras PF00071.22 EGD98583.1 - 8.9e-53 178.2 0.0 1e-52 178.0 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EGD98583.1 - 6.1e-19 68.4 0.0 8.7e-19 67.9 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EGD98583.1 - 4.4e-06 26.3 0.0 6.2e-06 25.8 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family DUF1349 PF07081.11 EGD98584.1 - 3.5e-31 108.3 0.0 3.2e-30 105.2 0.0 1.9 1 1 0 1 1 1 1 Protein of unknown function (DUF1349) MFS_1 PF07690.16 EGD98585.1 - 4.7e-21 75.1 39.1 7.8e-20 71.1 39.1 2.2 1 1 0 1 1 1 1 Major Facilitator Superfamily DUF2530 PF10745.9 EGD98585.1 - 7.2 6.9 8.7 0.78 10.0 1.2 3.1 2 1 2 4 4 4 0 Protein of unknown function (DUF2530) p450 PF00067.22 EGD98586.1 - 1.6e-47 162.3 0.0 2.1e-47 162.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 NAPRTase PF04095.16 EGD98586.1 - 0.081 12.5 0.0 0.19 11.3 0.0 1.5 1 0 0 1 1 1 0 Nicotinate phosphoribosyltransferase (NAPRTase) family Vint PF14623.6 EGD98587.1 - 1.9e-59 200.3 0.0 4.6e-59 199.0 0.0 1.7 1 0 0 1 1 1 1 Hint-domain Vwaint PF14624.6 EGD98587.1 - 3.9e-25 87.8 0.0 7.2e-25 86.9 0.0 1.4 1 0 0 1 1 1 1 VWA / Hh protein intein-like VWA PF00092.28 EGD98587.1 - 1.1e-17 64.9 0.0 2e-17 64.0 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 EGD98587.1 - 1.3e-13 51.6 0.0 2.6e-13 50.6 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.6 EGD98587.1 - 1.4e-12 47.8 0.0 1.3e-09 38.1 0.0 3.1 2 1 0 2 2 2 2 von Willebrand factor type A domain ABC_membrane PF00664.23 EGD98588.1 - 1.8e-103 346.0 26.2 6.5e-55 186.7 8.1 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EGD98588.1 - 3.4e-67 225.2 0.0 6.3e-33 114.2 0.0 2.4 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EGD98588.1 - 7.1e-14 51.8 0.2 0.00011 21.7 0.0 4.2 3 1 1 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 EGD98588.1 - 1.1e-06 28.9 0.3 0.11 12.7 0.0 3.2 2 2 0 2 2 2 2 AAA domain AAA_29 PF13555.6 EGD98588.1 - 3e-06 26.9 3.9 0.0018 18.0 0.1 2.9 3 0 0 3 3 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 EGD98588.1 - 3.5e-06 27.5 1.6 0.12 12.8 0.1 3.0 2 2 0 2 2 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 EGD98588.1 - 4.9e-06 26.5 0.3 0.08 12.8 0.0 2.8 3 0 0 3 3 3 2 RsgA GTPase AAA_21 PF13304.6 EGD98588.1 - 2.3e-05 24.4 0.4 0.3 10.9 0.0 3.8 3 1 0 4 4 4 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_30 PF13604.6 EGD98588.1 - 8.4e-05 22.4 0.7 0.7 9.6 0.0 3.1 3 1 0 3 3 2 2 AAA domain AAA_18 PF13238.6 EGD98588.1 - 0.00014 22.4 0.0 0.18 12.4 0.0 2.5 2 0 0 2 2 2 1 AAA domain ABC_ATPase PF09818.9 EGD98588.1 - 0.00025 20.0 0.5 0.77 8.5 0.0 3.2 3 0 0 3 3 3 2 Predicted ATPase of the ABC class AAA_5 PF07728.14 EGD98588.1 - 0.00045 20.2 0.2 0.17 11.9 0.0 3.1 4 0 0 4 4 2 1 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 EGD98588.1 - 0.00046 19.8 0.0 0.19 11.2 0.0 2.5 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_15 PF13175.6 EGD98588.1 - 0.00056 19.7 0.0 0.28 10.9 0.0 2.2 2 0 0 2 2 2 1 AAA ATPase domain AAA_23 PF13476.6 EGD98588.1 - 0.00082 19.9 0.1 0.6 10.6 0.0 2.5 2 0 0 2 2 2 1 AAA domain Rad17 PF03215.15 EGD98588.1 - 0.0011 18.9 0.0 0.054 13.4 0.0 2.4 2 0 0 2 2 2 1 Rad17 P-loop domain AAA PF00004.29 EGD98588.1 - 0.0012 19.3 0.7 1.7 9.1 0.0 3.8 4 0 0 4 4 4 1 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.6 EGD98588.1 - 0.0013 18.3 0.5 0.45 10.1 0.0 2.9 4 0 0 4 4 3 1 AAA domain Zeta_toxin PF06414.12 EGD98588.1 - 0.0025 17.1 0.0 0.18 11.0 0.0 2.6 2 0 0 2 2 2 1 Zeta toxin SRP54 PF00448.22 EGD98588.1 - 0.0029 17.3 0.1 2.7 7.6 0.0 2.4 2 0 0 2 2 2 2 SRP54-type protein, GTPase domain AAA_33 PF13671.6 EGD98588.1 - 0.0061 16.7 0.2 4.4 7.5 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_28 PF13521.6 EGD98588.1 - 0.011 15.9 0.5 4.2 7.6 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 EGD98588.1 - 0.013 15.2 0.1 1 9.0 0.0 2.6 2 0 0 2 2 2 0 AAA domain SbcCD_C PF13558.6 EGD98588.1 - 0.031 14.5 3.6 1.3 9.3 0.7 3.5 2 2 0 2 2 2 0 Putative exonuclease SbcCD, C subunit G-alpha PF00503.20 EGD98588.1 - 0.047 12.9 0.0 5.9 5.9 0.0 2.2 2 0 0 2 2 2 0 G-protein alpha subunit AAA_14 PF13173.6 EGD98588.1 - 0.07 13.2 0.0 15 5.6 0.0 3.5 4 0 0 4 4 4 0 AAA domain NB-ARC PF00931.22 EGD98588.1 - 0.077 12.2 0.2 6.2 5.9 0.0 2.3 2 0 0 2 2 2 0 NB-ARC domain PRK PF00485.18 EGD98588.1 - 0.1 12.3 0.2 3.8 7.2 0.0 2.3 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family MMR_HSR1 PF01926.23 EGD98588.1 - 0.11 12.6 0.1 29 4.8 0.0 2.8 2 0 0 2 2 2 0 50S ribosome-binding GTPase ATPase PF06745.13 EGD98588.1 - 0.12 11.7 0.5 8.5 5.6 0.0 2.4 2 0 0 2 2 2 0 KaiC RNA_helicase PF00910.22 EGD98588.1 - 0.13 12.6 0.4 8.5 6.8 0.0 2.9 3 0 0 3 3 2 0 RNA helicase AAA_17 PF13207.6 EGD98588.1 - 2.6 8.5 4.9 15 6.0 0.0 3.4 4 1 0 4 4 2 0 AAA domain X PF00739.19 EGD98589.1 - 0.00047 20.3 0.8 0.087 13.0 0.1 2.2 2 0 0 2 2 2 2 Trans-activation protein X CBFNT PF08143.11 EGD98589.1 - 5 8.6 9.1 0.74 11.3 3.5 2.0 2 0 0 2 2 2 0 CBFNT (NUC161) domain CAP59_mtransfer PF11735.8 EGD98590.1 - 2.6e-71 240.1 0.0 3.3e-71 239.8 0.0 1.1 1 0 0 1 1 1 1 Cryptococcal mannosyltransferase 1 Stk19 PF10494.9 EGD98591.1 - 0.1 12.3 0.0 0.19 11.4 0.0 1.4 1 0 0 1 1 1 0 Serine-threonine protein kinase 19 Mitofilin PF09731.9 EGD98591.1 - 0.78 8.5 12.0 1.2 7.9 12.0 1.2 1 0 0 1 1 1 0 Mitochondrial inner membrane protein DUF3530 PF12048.8 EGD98591.1 - 8 5.8 10.3 2.2 7.6 0.9 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3530) GST_N PF02798.20 EGD98596.1 - 1e-15 57.8 0.0 1.9e-15 56.9 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 EGD98596.1 - 1.8e-14 53.9 0.0 3.4e-14 53.0 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EGD98596.1 - 5.5e-11 42.6 0.1 1.5e-10 41.2 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EGD98596.1 - 7.2e-11 42.2 0.0 1.5e-10 41.2 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EGD98596.1 - 2.1e-10 40.6 0.0 4.1e-10 39.7 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EGD98596.1 - 3.4e-06 27.0 0.0 8.1e-06 25.8 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_4 PF17172.4 EGD98596.1 - 0.12 13.1 0.0 0.43 11.3 0.0 1.9 1 1 0 1 1 1 0 Glutathione S-transferase N-terminal domain APH PF01636.23 EGD98597.1 - 6.2e-06 26.3 0.0 0.00024 21.1 0.0 2.1 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 EGD98597.1 - 0.012 15.0 0.0 0.017 14.5 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family HSDR_N_2 PF13588.6 EGD98598.1 - 0.024 14.6 0.0 0.059 13.4 0.0 1.6 1 0 0 1 1 1 0 Type I restriction enzyme R protein N terminus (HSDR_N) HSDR_N PF04313.14 EGD98598.1 - 0.12 12.3 0.0 0.27 11.1 0.0 1.5 1 1 0 1 1 1 0 Type I restriction enzyme R protein N terminus (HSDR_N) Iwr1 PF08574.10 EGD98599.1 - 7.5e-19 68.5 4.8 7.5e-19 68.5 4.8 3.0 3 1 1 4 4 4 1 Transcription factor Iwr1 RRM_1 PF00076.22 EGD98600.1 - 1.7e-40 136.7 0.0 5.3e-12 45.4 0.0 4.4 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EGD98600.1 - 1e-14 54.1 0.0 0.0053 16.6 0.0 4.3 4 0 0 4 4 4 4 Occluded RNA-recognition motif RRM PF10378.9 EGD98600.1 - 2.1e-05 24.1 5.0 2.1e-05 24.1 5.0 2.8 2 1 0 2 2 2 1 Putative RRM domain DUF4523 PF15023.6 EGD98600.1 - 3.4e-05 23.7 0.0 0.59 9.9 0.0 3.2 3 0 0 3 3 3 2 Protein of unknown function (DUF4523) RRM_7 PF16367.5 EGD98600.1 - 0.00014 21.9 0.0 0.26 11.4 0.0 3.6 3 0 0 3 3 3 1 RNA recognition motif RRM_3 PF08777.11 EGD98600.1 - 0.00037 20.5 0.0 0.57 10.3 0.0 2.9 3 0 0 3 3 3 2 RNA binding motif RRM_Rrp7 PF17799.1 EGD98600.1 - 0.037 13.8 0.0 1.3 8.8 0.0 2.9 2 1 1 3 3 3 0 Rrp7 RRM-like N-terminal domain HD PF01966.22 EGD98601.1 - 0.00048 20.4 0.0 0.00095 19.4 0.0 1.5 1 1 0 1 1 1 1 HD domain DIOX_N PF14226.6 EGD98602.1 - 1.8e-22 80.3 0.0 2.5e-22 79.8 0.0 1.2 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EGD98602.1 - 4.3e-19 68.9 0.0 9.2e-19 67.8 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DUF723 PF05265.13 EGD98602.1 - 0.13 12.2 0.0 0.28 11.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF723) Pkinase PF00069.25 EGD98603.1 - 2.3e-27 96.0 0.0 2.9e-27 95.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD98603.1 - 1.2e-24 87.0 0.0 1.9e-24 86.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EGD98603.1 - 8.2e-05 22.0 0.0 0.00012 21.5 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EGD98603.1 - 0.0072 15.7 0.0 0.018 14.4 0.0 1.6 1 1 0 1 1 1 1 Kinase-like APH PF01636.23 EGD98603.1 - 0.0083 16.1 0.0 0.012 15.5 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family YukC PF10140.9 EGD98603.1 - 0.017 14.0 0.0 0.024 13.5 0.0 1.1 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukC RIO1 PF01163.22 EGD98603.1 - 0.02 14.5 0.0 0.027 14.1 0.0 1.2 1 0 0 1 1 1 0 RIO1 family Choline_kinase PF01633.20 EGD98603.1 - 0.041 13.5 0.6 0.4 10.2 0.5 2.2 1 1 1 2 2 2 0 Choline/ethanolamine kinase zinc_ribbon_15 PF17032.5 EGD98604.1 - 0.0026 18.5 1.2 0.0039 17.9 1.2 1.2 1 0 0 1 1 1 1 zinc-ribbon family RecR PF02132.15 EGD98604.1 - 0.04 13.5 0.8 0.89 9.2 0.0 2.2 2 0 0 2 2 2 0 RecR protein zf-LITAF-like PF10601.9 EGD98604.1 - 1.8 8.9 8.6 7.1 7.0 0.4 2.2 1 1 1 2 2 2 0 LITAF-like zinc ribbon domain Dynein_light PF01221.18 EGD98605.1 - 1.3e-37 127.9 1.8 1.6e-37 127.7 1.8 1.1 1 0 0 1 1 1 1 Dynein light chain type 1 DUF1805 PF08827.11 EGD98605.1 - 0.16 12.3 0.5 0.23 11.8 0.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1805) RRM_1 PF00076.22 EGD98606.1 - 4.3e-73 241.1 0.2 5.4e-19 67.8 0.0 5.4 5 0 0 5 5 5 5 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 EGD98606.1 - 2.9e-07 30.5 0.0 0.39 10.8 0.0 5.0 5 0 0 5 5 5 3 Limkain b1 Nup35_RRM_2 PF14605.6 EGD98606.1 - 7.9e-07 29.0 0.0 0.0044 17.0 0.0 4.5 5 0 0 5 5 5 1 Nup53/35/40-type RNA recognition motif RRM_7 PF16367.5 EGD98606.1 - 1.6e-05 24.9 0.0 1.5 9.0 0.0 4.0 4 0 0 4 4 4 2 RNA recognition motif RRM_occluded PF16842.5 EGD98606.1 - 6.7e-05 22.7 0.1 0.15 12.0 0.0 3.9 4 0 0 4 4 4 1 Occluded RNA-recognition motif RRM_5 PF13893.6 EGD98606.1 - 0.00022 20.8 0.0 0.016 14.8 0.0 2.8 2 1 1 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_2 PF04059.12 EGD98606.1 - 0.076 13.2 0.0 11 6.3 0.0 2.8 3 0 0 3 3 3 0 RNA recognition motif 2 Rota_NS53 PF00981.17 EGD98606.1 - 0.18 10.6 0.1 0.27 10.1 0.1 1.2 1 0 0 1 1 1 0 Rotavirus RNA-binding Protein 53 (NS53) Aldo_ket_red PF00248.21 EGD98607.1 - 9.2e-44 149.8 0.0 1.2e-43 149.5 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family Pkinase PF00069.25 EGD98609.1 - 2e-11 43.8 0.0 2.3e-11 43.6 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD98609.1 - 0.034 13.4 0.0 0.052 12.8 0.0 1.3 1 1 0 1 1 1 0 Protein tyrosine kinase NIF PF03031.18 EGD98610.1 - 1.2e-54 184.3 0.5 1.8e-54 183.7 0.5 1.3 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase DNase_NucA_NucB PF14040.6 EGD98610.1 - 0.019 15.3 0.1 0.019 15.3 0.1 2.3 2 1 0 2 2 2 0 Deoxyribonuclease NucA/NucB LRR_4 PF12799.7 EGD98611.1 - 7e-36 121.7 72.3 2.7e-08 34.0 5.2 6.5 1 1 7 9 9 9 9 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EGD98611.1 - 4.2e-21 74.5 37.5 6.1e-06 25.9 5.8 6.1 3 2 1 5 5 5 5 Leucine rich repeat LRR_9 PF14580.6 EGD98611.1 - 1.4e-14 54.0 19.5 3e-07 30.1 3.8 4.2 1 1 3 4 4 4 4 Leucine-rich repeat LRR_6 PF13516.6 EGD98611.1 - 0.00044 20.1 26.1 0.17 12.0 0.2 7.1 8 0 0 8 8 8 4 Leucine Rich repeat LRR_1 PF00560.33 EGD98611.1 - 0.001 19.3 31.1 2.9 8.8 0.9 8.9 10 0 0 10 10 10 3 Leucine Rich Repeat ABC_membrane_2 PF06472.15 EGD98612.1 - 4.6e-86 288.6 0.0 9.9e-86 287.5 0.0 1.6 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.27 EGD98612.1 - 5.4e-18 65.8 0.0 9.7e-18 65.0 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_23 PF13476.6 EGD98612.1 - 0.0014 19.2 0.8 0.045 14.2 0.0 2.4 3 0 0 3 3 3 1 AAA domain AAA_29 PF13555.6 EGD98612.1 - 0.0038 16.9 0.0 0.16 11.7 0.0 2.4 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_21 PF13304.6 EGD98612.1 - 0.014 15.2 0.0 0.027 14.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA PF00004.29 EGD98612.1 - 0.028 14.9 0.5 0.47 10.9 0.0 2.9 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.21 EGD98612.1 - 0.052 12.9 0.0 0.09 12.2 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_16 PF13191.6 EGD98612.1 - 0.09 13.2 0.0 0.26 11.6 0.0 1.8 1 0 0 1 1 1 0 AAA ATPase domain ALIX_LYPXL_bnd PF13949.6 EGD98612.1 - 0.091 12.0 0.1 0.15 11.3 0.1 1.3 1 0 0 1 1 1 0 ALIX V-shaped domain binding to HIV SMC_N PF02463.19 EGD98612.1 - 0.1 12.0 0.1 3.6 6.9 0.1 2.4 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain Sigma54_activat PF00158.26 EGD98612.1 - 0.18 11.5 0.0 0.34 10.6 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain RuvB_N PF05496.12 EGD98612.1 - 0.18 11.5 0.0 0.47 10.2 0.0 1.6 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain Clr2 PF10383.9 EGD98613.1 - 9.9e-23 81.5 0.0 1.8e-22 80.7 0.0 1.4 1 0 0 1 1 1 1 Transcription-silencing protein Clr2 Clr2_transil PF16761.5 EGD98613.1 - 4.9e-17 62.5 0.7 1.4e-16 61.1 0.7 1.9 1 0 0 1 1 1 1 Transcription-silencing protein, cryptic loci regulator Clr2 2OG-FeII_Oxy PF03171.20 EGD98614.1 - 0.00026 21.4 0.0 0.001 19.5 0.0 1.9 1 1 1 2 2 2 1 2OG-Fe(II) oxygenase superfamily SAD_SRA PF02182.17 EGD98615.1 - 7.1e-27 94.0 0.0 1.6e-26 92.9 0.0 1.7 1 0 0 1 1 1 1 SAD/SRA domain FAST_1 PF06743.15 EGD98615.1 - 0.082 12.9 0.0 0.18 11.8 0.0 1.5 1 0 0 1 1 1 0 FAST kinase-like protein, subdomain 1 ApoM PF11032.8 EGD98615.1 - 0.12 12.1 0.1 0.22 11.2 0.1 1.3 1 0 0 1 1 1 0 ApoM domain CLTH PF10607.9 EGD98616.1 - 2.3e-29 102.2 0.0 4.8e-29 101.2 0.0 1.5 2 0 0 2 2 2 1 CTLH/CRA C-terminal to LisH motif domain zf-RING_UBOX PF13445.6 EGD98616.1 - 4.8e-08 32.9 0.7 9.9e-08 31.9 0.7 1.6 1 0 0 1 1 1 1 RING-type zinc-finger Rtf2 PF04641.12 EGD98616.1 - 0.00021 20.8 0.4 0.00039 19.9 0.0 1.6 2 0 0 2 2 2 1 Rtf2 RING-finger zf-RING_5 PF14634.6 EGD98616.1 - 0.00085 19.2 0.5 0.0016 18.3 0.5 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 EGD98616.1 - 0.0014 18.9 0.9 0.0026 18.0 0.9 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 EGD98616.1 - 0.015 15.2 0.7 0.029 14.2 0.7 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EGD98616.1 - 0.016 15.0 0.9 0.033 14.0 0.9 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 EGD98616.1 - 0.029 14.2 1.9 0.058 13.2 1.9 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EGD98616.1 - 0.03 14.2 1.2 0.069 13.0 1.2 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) PG_binding_1 PF01471.18 EGD98617.1 - 0.031 14.5 0.0 3.5 7.9 0.0 3.3 3 0 0 3 3 3 0 Putative peptidoglycan binding domain zf-Tim10_DDP PF02953.15 EGD98618.1 - 9.3e-22 76.4 0.6 9.3e-22 76.4 0.6 1.5 1 1 1 2 2 2 1 Tim10/DDP family zinc finger Tom5 PF10642.9 EGD98618.1 - 0.029 14.4 3.9 0.33 11.0 0.1 2.1 2 0 0 2 2 2 0 Mitochondrial import receptor subunit or translocase SUIM_assoc PF16619.5 EGD98618.1 - 1.7 8.8 5.2 2.5 8.2 5.2 1.5 1 1 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 tRNA-synt_2 PF00152.20 EGD98619.1 - 5.9e-70 235.8 0.0 7.6e-70 235.5 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 EGD98619.1 - 6.2e-10 38.9 0.0 1.3e-09 37.9 0.0 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 EGD98619.1 - 4.4e-05 23.1 0.0 0.014 14.9 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) BTB PF00651.31 EGD98620.1 - 1.1e-07 32.1 0.0 1.6e-07 31.5 0.0 1.2 1 0 0 1 1 1 1 BTB/POZ domain Skp1_POZ PF03931.15 EGD98620.1 - 0.001 19.2 0.0 0.0017 18.5 0.0 1.4 1 0 0 1 1 1 1 Skp1 family, tetramerisation domain PCI PF01399.27 EGD98621.1 - 4.9e-10 39.8 0.0 9.3e-10 39.0 0.0 1.4 1 0 0 1 1 1 1 PCI domain DUF433 PF04255.14 EGD98621.1 - 0.081 12.8 0.0 0.21 11.5 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF433) Ribosomal_L18A PF01775.17 EGD98622.1 - 2.7e-54 182.4 1.4 3.4e-54 182.1 1.4 1.1 1 0 0 1 1 1 1 Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A DUF2887 PF11103.8 EGD98622.1 - 0.028 14.4 0.0 0.036 14.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2887) NAD_binding_1 PF00175.21 EGD98623.1 - 1.8e-31 109.0 0.0 2.8e-31 108.4 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 EGD98623.1 - 4.7e-24 84.6 0.0 9e-24 83.7 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 EGD98623.1 - 1.9e-08 34.5 0.0 2.5e-05 24.4 0.0 2.2 2 0 0 2 2 2 2 Ferric reductase NAD binding domain HMG_box PF00505.19 EGD98624.1 - 6.7e-12 45.7 2.5 2.7e-11 43.7 2.5 2.1 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EGD98624.1 - 1.1e-07 32.3 2.3 5.4e-07 30.1 2.3 2.3 1 0 0 1 1 1 1 HMG-box domain Amidohydro_1 PF01979.20 EGD98625.1 - 1e-72 245.3 0.3 2e-72 244.4 0.3 1.4 1 0 0 1 1 1 1 Amidohydrolase family Urease_alpha PF00449.20 EGD98625.1 - 2.9e-54 182.5 1.1 6.5e-54 181.4 1.1 1.6 1 0 0 1 1 1 1 Urease alpha-subunit, N-terminal domain Urease_beta PF00699.20 EGD98625.1 - 1.2e-40 137.4 0.3 9.4e-40 134.6 0.0 2.2 2 0 0 2 2 2 1 Urease beta subunit Urease_gamma PF00547.18 EGD98625.1 - 4.6e-31 107.1 0.0 1.1e-30 105.8 0.0 1.7 1 0 0 1 1 1 1 Urease, gamma subunit Amidohydro_3 PF07969.11 EGD98625.1 - 2.5e-07 30.5 0.1 0.0002 21.0 0.0 2.7 2 1 0 2 2 2 2 Amidohydrolase family Lactamase_B_2 PF12706.7 EGD98626.1 - 1.6e-07 31.1 0.0 3.2e-07 30.1 0.0 1.5 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 EGD98626.1 - 0.00068 19.7 0.0 0.0013 18.8 0.0 1.4 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily DRMBL PF07522.14 EGD98626.1 - 0.00087 19.5 0.0 0.0029 17.8 0.0 1.9 1 0 0 1 1 1 1 DNA repair metallo-beta-lactamase NicO PF03824.16 EGD98627.1 - 0.14 11.5 3.4 0.2 10.9 3.4 1.2 1 0 0 1 1 1 0 High-affinity nickel-transport protein SelP_N PF04592.14 EGD98627.1 - 7.7 5.9 14.4 13 5.1 14.4 1.3 1 0 0 1 1 1 0 Selenoprotein P, N terminal region NPR2 PF06218.11 EGD98628.1 - 1.4e-134 449.2 0.0 1e-133 446.4 0.0 2.2 1 1 0 1 1 1 1 Nitrogen permease regulator 2 Rox3 PF08633.10 EGD98628.1 - 0.4 10.9 2.2 1.3 9.3 2.6 1.5 2 0 0 2 2 2 0 Rox3 mediator complex subunit Ada3 PF10198.9 EGD98629.1 - 6.1e-52 175.3 0.0 6.1e-52 175.3 0.0 2.0 2 0 0 2 2 2 1 Histone acetyltransferases subunit 3 DUF572 PF04502.13 EGD98629.1 - 0.0034 17.1 2.9 0.0068 16.1 2.9 1.4 1 0 0 1 1 1 1 Family of unknown function (DUF572) zf-RING_2 PF13639.6 EGD98630.1 - 1.5e-10 41.2 8.4 2.7e-10 40.4 8.4 1.4 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 EGD98630.1 - 1.3e-08 34.5 1.4 2.6e-08 33.5 1.4 1.6 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 EGD98630.1 - 6.1e-07 29.2 5.2 1.1e-06 28.4 5.2 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EGD98630.1 - 9.9e-06 25.4 2.9 1.8e-05 24.6 2.9 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 EGD98630.1 - 1.4e-05 24.8 3.7 2.5e-05 24.0 3.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EGD98630.1 - 6.5e-05 22.9 3.6 6.5e-05 22.9 3.6 1.9 1 1 0 1 1 1 1 RING-type zinc-finger zf-rbx1 PF12678.7 EGD98630.1 - 0.0011 19.2 7.1 0.0033 17.7 7.1 1.8 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 EGD98630.1 - 0.0054 16.7 2.0 0.012 15.7 2.0 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_3 PF13920.6 EGD98630.1 - 0.019 14.8 5.3 0.036 13.9 5.3 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) LapA_dom PF06305.11 EGD98630.1 - 0.12 12.2 2.3 0.3 10.9 2.3 1.6 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain zf-C3HC4_4 PF15227.6 EGD98630.1 - 0.31 11.2 4.1 0.65 10.2 4.1 1.6 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 EGD98630.1 - 0.36 10.7 11.2 0.58 10.1 8.8 2.1 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-P11 PF03854.14 EGD98630.1 - 5.5 6.7 6.4 0.65 9.7 1.2 2.1 2 0 0 2 2 2 0 P-11 zinc finger FRG1 PF06229.12 EGD98631.1 - 4.8e-53 179.7 0.0 6.3e-53 179.3 0.0 1.2 1 0 0 1 1 1 1 FRG1-like domain Fascin PF06268.13 EGD98631.1 - 0.087 13.0 0.0 0.15 12.3 0.0 1.4 1 0 0 1 1 1 0 Fascin domain ADH_zinc_N PF00107.26 EGD98632.1 - 1.6e-16 60.5 0.0 2.3e-16 60.0 0.0 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 EGD98632.1 - 3e-12 46.5 0.0 4.2e-12 46.0 0.0 1.2 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus ADH_N PF08240.12 EGD98632.1 - 4.3e-09 36.2 1.0 1.5e-08 34.5 0.7 2.0 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 EGD98632.1 - 2.4e-06 28.7 0.0 3.9e-06 28.0 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Sacchrp_dh_NADP PF03435.18 EGD98632.1 - 0.0038 17.5 0.0 0.0061 16.8 0.0 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain NAD_binding_7 PF13241.6 EGD98632.1 - 0.0071 16.8 0.0 0.012 16.0 0.0 1.3 1 0 0 1 1 1 1 Putative NAD(P)-binding FAD_binding_3 PF01494.19 EGD98632.1 - 0.032 13.5 1.0 0.047 12.9 1.0 1.2 1 0 0 1 1 1 0 FAD binding domain NADH_4Fe-4S PF10589.9 EGD98632.1 - 0.067 13.3 0.6 0.2 11.7 0.6 1.8 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region NAD_binding_3 PF03447.16 EGD98632.1 - 0.1 13.3 0.0 0.42 11.3 0.0 2.0 2 1 0 2 2 2 0 Homoserine dehydrogenase, NAD binding domain HECT PF00632.25 EGD98633.1 - 1.1e-68 232.1 0.0 1.4e-68 231.6 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Ribosomal_L15e PF00827.17 EGD98634.1 - 7.5e-89 296.5 12.2 9.3e-89 296.2 12.2 1.0 1 0 0 1 1 1 1 Ribosomal L15 FXMRP1_C_core PF12235.8 EGD98634.1 - 3.4 8.3 9.4 0.39 11.3 3.3 2.0 2 0 0 2 2 2 0 Fragile X-related 1 protein core C terminal AAA_assoc_2 PF16193.5 EGD98635.1 - 0.0015 18.8 0.6 0.004 17.5 0.6 1.7 1 0 0 1 1 1 1 AAA C-terminal domain WD40 PF00400.32 EGD98636.1 - 7.6e-31 105.7 10.4 2.1e-07 31.5 0.0 7.2 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EGD98636.1 - 2.5e-13 50.1 0.0 0.00018 21.7 0.0 4.8 3 2 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain EF-hand_1 PF00036.32 EGD98637.1 - 1.3e-13 49.4 3.7 3.1e-06 26.3 0.4 3.3 3 0 0 3 3 3 2 EF hand ZZ PF00569.17 EGD98637.1 - 1.2e-11 44.2 4.4 2.2e-11 43.4 4.4 1.4 1 0 0 1 1 1 1 Zinc finger, ZZ type EF-hand_7 PF13499.6 EGD98637.1 - 1.1e-10 41.8 7.2 3.4e-08 33.8 1.7 2.8 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 EGD98637.1 - 3.4e-10 39.0 3.4 0.00018 21.2 0.1 2.9 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 EGD98637.1 - 5.5e-07 28.8 1.9 0.0022 17.4 0.2 2.8 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 EGD98637.1 - 1.9e-05 24.4 4.6 0.0063 16.3 0.4 3.7 4 0 0 4 4 4 2 EF-hand domain pair C1_2 PF03107.16 EGD98637.1 - 0.0072 16.6 3.8 0.015 15.6 3.8 1.5 1 0 0 1 1 1 1 C1 domain HemY_N PF07219.13 EGD98637.1 - 0.12 12.6 0.1 0.28 11.4 0.1 1.5 1 0 0 1 1 1 0 HemY protein N-terminus MFS_1 PF07690.16 EGD98638.1 - 3.4e-50 170.9 68.1 4.8e-49 167.2 48.8 2.5 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EGD98638.1 - 4.3e-14 52.2 8.8 4.3e-14 52.2 8.8 3.6 4 0 0 4 4 4 2 Sugar (and other) transporter TMEM220 PF15071.6 EGD98638.1 - 3.4 8.5 7.5 2 9.2 3.4 2.9 2 1 0 2 2 2 0 Transmembrane family 220, helix Peptidase_M24 PF00557.24 EGD98639.1 - 5.5e-49 166.7 0.0 6.6e-49 166.4 0.0 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 zf-C6H2 PF15801.5 EGD98639.1 - 1.6e-19 69.9 5.3 3.1e-19 69.0 5.3 1.5 1 0 0 1 1 1 1 zf-MYND-like zinc finger, mRNA-binding zf-MYND PF01753.18 EGD98639.1 - 0.002 18.2 6.0 0.002 18.2 6.0 2.2 2 0 0 2 2 2 1 MYND finger zf-HIT PF04438.16 EGD98639.1 - 1.7 8.6 4.8 4 7.4 4.8 1.7 1 0 0 1 1 1 0 HIT zinc finger FAD_binding_3 PF01494.19 EGD98640.1 - 1.4e-15 57.4 0.0 3.4e-14 52.9 0.0 2.8 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.24 EGD98640.1 - 9.3e-05 22.2 0.0 0.0082 15.8 0.1 2.6 2 1 0 2 2 2 1 FAD dependent oxidoreductase FAD_oxidored PF12831.7 EGD98640.1 - 0.00051 19.5 1.0 0.03 13.7 0.3 2.8 3 0 0 3 3 3 1 FAD dependent oxidoreductase GIDA PF01134.22 EGD98640.1 - 0.0032 16.6 0.0 0.007 15.5 0.0 1.5 1 1 0 1 1 1 1 Glucose inhibited division protein A HI0933_like PF03486.14 EGD98640.1 - 0.0039 16.0 0.0 0.0064 15.3 0.0 1.3 1 0 0 1 1 1 1 HI0933-like protein SE PF08491.10 EGD98640.1 - 0.0056 15.8 0.0 0.012 14.7 0.0 1.5 1 1 0 1 1 1 1 Squalene epoxidase NAD_binding_8 PF13450.6 EGD98640.1 - 0.0064 16.7 0.1 0.037 14.2 0.0 2.3 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EGD98640.1 - 0.0075 15.5 0.0 0.011 15.0 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EGD98640.1 - 0.017 15.7 0.1 0.48 11.0 0.0 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 EGD98640.1 - 0.13 11.6 0.0 0.19 11.0 0.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Sugar_tr PF00083.24 EGD98642.1 - 6.4e-82 275.8 22.3 7.4e-82 275.6 22.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EGD98642.1 - 8.9e-13 47.9 40.2 3.2e-10 39.5 34.4 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 EGD98642.1 - 0.0035 16.3 5.3 0.0035 16.3 5.3 2.3 2 0 0 2 2 2 1 MFS_1 like family Ribosomal_S8 PF00410.19 EGD98643.1 - 2.3e-14 53.4 0.0 3.9e-13 49.5 0.0 2.2 1 1 0 1 1 1 1 Ribosomal protein S8 DUF4834 PF16118.5 EGD98644.1 - 0.65 11.0 2.2 40 5.2 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) PKI PF02827.16 EGD98644.1 - 6.2 7.1 6.6 0.88 9.8 2.1 1.9 2 0 0 2 2 2 0 cAMP-dependent protein kinase inhibitor PIP5K PF01504.18 EGD98646.1 - 4.5e-38 131.1 2.3 7.1e-29 100.9 1.0 2.4 2 1 1 3 3 3 2 Phosphatidylinositol-4-phosphate 5-Kinase baeRF_family5 PF18846.1 EGD98646.1 - 0.017 15.3 0.1 0.082 13.1 0.0 2.1 2 1 0 2 2 2 0 Bacterial archaeo-eukaryotic release factor family 5 Cpn60_TCP1 PF00118.24 EGD98647.1 - 6.1e-32 110.9 0.0 1.1e-31 110.1 0.0 1.3 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family FYVE PF01363.21 EGD98647.1 - 4.6e-15 55.5 4.1 4.6e-15 55.5 4.1 2.1 2 0 0 2 2 2 1 FYVE zinc finger DZR PF12773.7 EGD98647.1 - 0.21 11.6 6.8 0.14 12.2 2.6 2.5 2 0 0 2 2 2 0 Double zinc ribbon C1_1 PF00130.22 EGD98647.1 - 1.3 8.9 10.7 0.017 15.0 2.9 1.8 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) TPP1 PF10341.9 EGD98648.1 - 5.2e-20 71.5 0.0 1.1e-19 70.5 0.0 1.6 1 0 0 1 1 1 1 Shelterin complex subunit, TPP1/ACD DUF523 PF04463.12 EGD98648.1 - 0.073 13.1 0.0 0.19 11.8 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF523) E2R135 PF11570.8 EGD98652.1 - 0.09 13.1 3.0 0.28 11.5 3.0 1.9 1 0 0 1 1 1 0 Coiled-coil receptor-binding R-domain of colicin E2 Spc7 PF08317.11 EGD98652.1 - 1.3 7.8 35.8 0.028 13.3 10.4 3.4 2 1 1 3 3 3 0 Spc7 kinetochore protein DUF1769 PF08588.10 EGD98653.1 - 8.1e-27 93.2 0.3 1.4e-26 92.5 0.3 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1769) Iso_dh PF00180.20 EGD98654.1 - 4.5e-97 325.3 0.0 9.6e-97 324.2 0.0 1.4 1 1 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase ICMT PF04140.14 EGD98654.1 - 0.18 12.2 0.0 0.32 11.5 0.0 1.3 1 0 0 1 1 1 0 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PK PF00224.21 EGD98656.1 - 1.2e-173 576.8 5.1 1.6e-173 576.5 5.1 1.1 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.16 EGD98656.1 - 8.9e-39 132.3 0.0 5.3e-38 129.9 0.0 2.2 2 0 0 2 2 2 1 Pyruvate kinase, alpha/beta domain HpcH_HpaI PF03328.14 EGD98656.1 - 8.5e-05 21.8 0.3 0.00027 20.2 0.1 1.8 2 0 0 2 2 2 1 HpcH/HpaI aldolase/citrate lyase family IMPDH PF00478.25 EGD98656.1 - 0.0037 16.3 0.1 0.041 12.9 0.0 2.2 2 0 0 2 2 2 1 IMP dehydrogenase / GMP reductase domain DUF218 PF02698.17 EGD98656.1 - 0.15 12.1 0.0 0.46 10.5 0.0 1.9 1 1 0 1 1 1 0 DUF218 domain SUR7 PF06687.12 EGD98657.1 - 6.6e-32 110.9 0.3 8.5e-32 110.5 0.3 1.2 1 0 0 1 1 1 1 SUR7/PalI family Ribosomal_S17_N PF16205.5 EGD98660.1 - 3.1e-33 114.0 0.4 5.8e-33 113.1 0.4 1.5 1 0 0 1 1 1 1 Ribosomal_S17 N-terminal Ribosomal_S17 PF00366.20 EGD98660.1 - 3e-27 94.5 0.4 5.8e-27 93.6 0.4 1.5 1 0 0 1 1 1 1 Ribosomal protein S17 Spc7_N PF15402.6 EGD98661.1 - 0 1055.8 46.8 0 1055.3 46.8 1.2 1 0 0 1 1 1 1 N-terminus of kinetochore NMS complex subunit Spc7 Spc7 PF08317.11 EGD98661.1 - 3e-118 394.2 1.3 3e-118 394.2 1.3 1.8 2 0 0 2 2 2 1 Spc7 kinetochore protein DUF745 PF05335.13 EGD98661.1 - 0.0065 16.2 3.0 0.0065 16.2 3.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF745) DUF4407 PF14362.6 EGD98661.1 - 8.4 5.6 9.2 5 6.4 5.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Pil1 PF13805.6 EGD98662.1 - 7.3e-126 419.1 0.0 1e-125 418.6 0.0 1.2 1 0 0 1 1 1 1 Eisosome component PIL1 FAM92 PF06730.11 EGD98662.1 - 0.089 12.2 1.3 0.17 11.3 0.6 1.7 1 1 0 2 2 2 0 FAM92 protein XPG_N PF00752.17 EGD98663.1 - 8.9e-35 119.2 0.0 2.2e-34 118.0 0.0 1.7 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.18 EGD98663.1 - 3.5e-25 88.2 0.0 9.8e-25 86.7 0.0 1.8 1 0 0 1 1 1 1 XPG I-region 5_3_exonuc PF01367.20 EGD98663.1 - 0.0003 21.3 0.0 0.0012 19.4 0.0 2.0 2 0 0 2 2 2 1 5'-3' exonuclease, C-terminal SAM fold Transposase_20 PF02371.16 EGD98663.1 - 0.027 14.8 0.0 0.068 13.5 0.0 1.6 1 0 0 1 1 1 0 Transposase IS116/IS110/IS902 family WD40 PF00400.32 EGD98664.1 - 9.4e-14 51.6 16.0 6e-06 26.9 0.4 9.5 10 0 0 10 10 10 4 WD domain, G-beta repeat DUF5554 PF17709.1 EGD98664.1 - 0.0078 16.3 0.0 0.025 14.7 0.0 1.8 1 0 0 1 1 1 1 Family of unknown function (DUF5554) Metallophos PF00149.28 EGD98666.1 - 1.5e-37 130.1 0.1 2.2e-37 129.5 0.1 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 EGD98666.1 - 3.5e-15 56.2 0.0 6.2e-15 55.4 0.0 1.4 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain WD40 PF00400.32 EGD98667.1 - 1.3e-19 70.2 12.8 0.00019 22.2 0.1 7.2 7 1 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EGD98667.1 - 1.3e-16 60.7 0.0 8e-08 32.5 0.0 5.5 3 1 3 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EGD98667.1 - 4.6e-05 23.4 0.3 0.012 15.5 0.0 2.7 3 0 0 3 3 3 2 Eukaryotic translation initiation factor eIF2A HIRA_B PF09453.10 EGD98667.1 - 0.0005 19.8 0.5 0.0017 18.1 0.5 2.0 1 0 0 1 1 1 1 HIRA B motif Ge1_WD40 PF16529.5 EGD98667.1 - 0.025 13.5 0.0 24 3.7 0.0 3.7 2 1 1 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 EGD98667.1 - 0.053 13.5 4.8 9.3 6.3 0.3 3.9 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat WD40_like PF17005.5 EGD98667.1 - 0.15 11.3 0.0 1.7 7.9 0.0 2.1 2 0 0 2 2 2 0 WD40-like domain DUF3128 PF11326.8 EGD98668.1 - 1 9.7 6.2 1.4e+02 2.9 6.2 3.1 1 1 0 1 1 1 0 Protein of unknown function (DUF3128) YabA PF06156.13 EGD98669.1 - 0.32 11.7 2.0 1.2 9.8 2.0 2.1 1 0 0 1 1 1 0 Initiation control protein YabA F-box-like PF12937.7 EGD98670.1 - 0.00077 19.3 0.3 0.0021 17.9 0.3 1.8 1 0 0 1 1 1 1 F-box-like PRANC PF09372.10 EGD98670.1 - 0.19 12.1 0.0 0.41 11.0 0.0 1.5 1 0 0 1 1 1 0 PRANC domain Gpr1_Fun34_YaaH PF01184.19 EGD98671.1 - 4.1e-80 268.3 18.3 5.2e-80 267.9 18.3 1.1 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family ANTH PF07651.16 EGD98672.1 - 1.3e-34 119.4 0.4 3.1e-18 65.8 0.1 2.2 1 1 1 2 2 2 2 ANTH domain ENTH PF01417.20 EGD98672.1 - 1.1e-09 38.4 0.0 4.8e-09 36.3 0.0 1.9 2 0 0 2 2 2 1 ENTH domain Memo PF01875.17 EGD98674.1 - 2.6e-59 200.6 0.0 3.3e-59 200.2 0.0 1.1 1 0 0 1 1 1 1 Memo-like protein Rad4 PF03835.15 EGD98676.1 - 1.3e-09 37.9 0.4 2.2e-09 37.2 0.4 1.3 1 0 0 1 1 1 1 Rad4 transglutaminase-like domain F-box PF00646.33 EGD98677.1 - 0.11 12.4 0.6 0.22 11.4 0.6 1.5 1 0 0 1 1 1 0 F-box domain ANAPC4_WD40 PF12894.7 EGD98678.1 - 1.6e-09 37.9 0.3 0.14 12.5 0.0 5.5 3 1 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EGD98678.1 - 1.1e-06 29.2 15.4 1.5 9.9 0.0 8.2 9 1 0 9 9 9 3 WD domain, G-beta repeat PQQ_2 PF13360.6 EGD98678.1 - 0.00014 21.5 0.2 0.0021 17.7 0.1 2.7 2 0 0 2 2 2 1 PQQ-like domain Ge1_WD40 PF16529.5 EGD98678.1 - 0.0079 15.2 0.0 0.3 10.0 0.0 2.8 3 0 0 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Lactonase PF10282.9 EGD98678.1 - 0.039 13.2 0.0 0.097 11.9 0.0 1.6 1 0 0 1 1 1 0 Lactonase, 7-bladed beta-propeller PQQ PF01011.21 EGD98678.1 - 0.095 12.7 1.1 38 4.4 0.1 3.6 3 0 0 3 3 3 0 PQQ enzyme repeat Treacle PF03546.14 EGD98678.1 - 5.3 5.7 8.8 0.13 11.0 2.1 1.6 2 0 0 2 2 2 0 Treacher Collins syndrome protein Treacle Cyclin_C PF02984.19 EGD98682.1 - 7.8e-10 38.9 2.0 3.3e-09 36.9 2.0 1.8 1 1 0 1 1 1 1 Cyclin, C-terminal domain Cyclin_N PF00134.23 EGD98682.1 - 0.0094 15.7 0.0 0.024 14.4 0.0 1.7 1 0 0 1 1 1 1 Cyclin, N-terminal domain START PF01852.19 EGD98682.1 - 0.037 13.4 0.0 0.081 12.3 0.0 1.5 1 1 0 1 1 1 0 START domain Acyl_transf_3 PF01757.22 EGD98684.1 - 0.00046 19.4 10.2 0.0011 18.1 10.2 1.6 1 1 0 1 1 1 1 Acyltransferase family Caps_synth_CapC PF14102.6 EGD98684.1 - 0.045 14.2 0.1 0.045 14.2 0.1 1.8 2 0 0 2 2 2 0 Capsule biosynthesis CapC Pyr_redox_2 PF07992.14 EGD98685.1 - 7.6e-15 54.9 0.0 3.4e-14 52.8 0.0 1.9 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EGD98685.1 - 0.0039 16.0 0.0 0.022 13.5 0.0 2.1 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox_3 PF13738.6 EGD98685.1 - 0.0068 15.7 5.5 2.3 7.4 0.1 3.0 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EGD98685.1 - 0.021 15.0 0.0 0.05 13.8 0.0 1.6 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 EGD98685.1 - 0.04 13.9 1.3 4.9 7.1 0.1 2.9 3 0 0 3 3 3 0 FAD-NAD(P)-binding Thi4 PF01946.17 EGD98685.1 - 0.042 13.1 0.0 0.087 12.1 0.0 1.4 1 0 0 1 1 1 0 Thi4 family K_oxygenase PF13434.6 EGD98685.1 - 0.043 12.9 0.0 2.6 7.1 0.0 2.2 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) GIDA PF01134.22 EGD98685.1 - 0.066 12.3 1.3 5.7 5.9 0.1 2.4 1 1 0 2 2 2 0 Glucose inhibited division protein A FAD_binding_3 PF01494.19 EGD98685.1 - 0.13 11.5 0.3 0.32 10.2 0.1 1.7 2 0 0 2 2 2 0 FAD binding domain MPDZ_u10 PF16667.5 EGD98687.1 - 0.043 14.7 4.1 0.057 14.3 4.1 1.3 1 1 0 1 1 1 0 Unstructured region 10 on multiple PDZ protein NAPRTase_N PF17767.1 EGD98688.1 - 0.0032 17.9 1.7 0.0052 17.2 1.7 1.3 1 0 0 1 1 1 1 Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain FKBP_C PF00254.28 EGD98689.1 - 1.8e-33 114.7 0.0 2.2e-33 114.4 0.0 1.1 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase Cyt-b5 PF00173.28 EGD98690.1 - 5.2e-17 61.8 0.0 8.1e-17 61.1 0.0 1.3 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Beta-lactamase PF00144.24 EGD98691.1 - 5.7e-26 91.5 0.1 8e-26 91.1 0.1 1.2 1 0 0 1 1 1 1 Beta-lactamase Zip PF02535.22 EGD98692.1 - 4.7e-67 226.6 6.0 5.5e-67 226.4 6.0 1.0 1 0 0 1 1 1 1 ZIP Zinc transporter Tom37 PF10568.9 EGD98693.1 - 3e-38 130.9 0.0 7.1e-38 129.7 0.0 1.7 1 0 0 1 1 1 1 Outer mitochondrial membrane transport complex protein GST_C_6 PF17171.4 EGD98693.1 - 1e-09 38.0 0.0 7.3e-09 35.3 0.0 2.4 3 0 0 3 3 3 1 Glutathione S-transferase, C-terminal domain GST_N_4 PF17172.4 EGD98693.1 - 0.0038 17.9 0.0 0.022 15.5 0.0 2.3 2 0 0 2 2 2 1 Glutathione S-transferase N-terminal domain Cupin_8 PF13621.6 EGD98694.1 - 1.3e-20 74.2 0.0 3.6e-20 72.8 0.0 1.7 1 1 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.12 EGD98694.1 - 6.7e-05 22.5 0.0 0.00022 20.8 0.0 1.7 2 0 0 2 2 2 1 Cupin superfamily protein JmjC PF02373.22 EGD98694.1 - 0.0091 16.4 0.0 0.018 15.5 0.0 1.5 2 0 0 2 2 2 1 JmjC domain, hydroxylase Cupin_2 PF07883.11 EGD98694.1 - 0.016 14.9 0.0 0.037 13.7 0.0 1.7 1 0 0 1 1 1 0 Cupin domain bZIP_2 PF07716.15 EGD98697.1 - 0.029 14.4 6.1 0.045 13.8 6.1 1.2 1 0 0 1 1 1 0 Basic region leucine zipper bZIP_1 PF00170.21 EGD98697.1 - 0.031 14.4 7.3 0.05 13.7 7.3 1.2 1 0 0 1 1 1 0 bZIP transcription factor Aminotran_4 PF01063.19 EGD98699.1 - 7.3e-36 124.1 0.0 9.5e-36 123.7 0.0 1.1 1 0 0 1 1 1 1 Amino-transferase class IV Pkinase PF00069.25 EGD98700.1 - 6.9e-19 68.2 0.0 2.8e-18 66.2 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD98700.1 - 6.4e-09 35.5 0.0 3.8e-08 32.9 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Peptidase_M49 PF03571.15 EGD98701.1 - 4.8e-246 817.4 0.0 9.9e-246 816.4 0.0 1.5 2 0 0 2 2 2 1 Peptidase family M49 PAD_porph PF04371.15 EGD98701.1 - 0.14 11.4 0.0 0.38 10.0 0.0 1.6 2 0 0 2 2 2 0 Porphyromonas-type peptidyl-arginine deiminase DUF3060 PF11259.8 EGD98702.1 - 0.014 15.1 0.5 0.53 10.0 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3060) Senescence_reg PF04520.13 EGD98702.1 - 1.8 9.3 6.2 12 6.7 6.2 2.1 1 1 0 1 1 1 0 Senescence regulator SNF5 PF04855.12 EGD98704.1 - 9.4e-82 274.4 0.0 1.2e-81 274.0 0.0 1.1 1 0 0 1 1 1 1 SNF5 / SMARCB1 / INI1 GATA PF00320.27 EGD98704.1 - 0.011 15.4 4.6 0.028 14.0 4.6 1.8 1 0 0 1 1 1 0 GATA zinc finger Rubredoxin_2 PF18073.1 EGD98704.1 - 3.6 7.4 10.7 1 9.2 1.0 2.5 2 0 0 2 2 2 0 Rubredoxin metal binding domain BHD_1 PF10403.9 EGD98705.1 - 0.031 14.1 0.0 0.075 12.9 0.0 1.6 1 0 0 1 1 1 0 Rad4 beta-hairpin domain 1 WD40 PF00400.32 EGD98707.1 - 5.4e-22 77.7 26.8 5.9e-06 26.9 0.2 7.1 6 2 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EGD98707.1 - 2.2e-11 43.9 8.6 0.00015 22.0 0.2 4.3 2 2 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain TFIIIC_delta PF12657.7 EGD98707.1 - 0.0011 19.0 11.1 0.078 12.9 2.7 2.8 1 1 2 3 3 3 2 Transcription factor IIIC subunit delta N-term Ank_2 PF12796.7 EGD98708.1 - 2e-33 114.8 7.1 5e-10 39.8 0.0 4.3 2 1 4 6 6 6 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EGD98708.1 - 7.5e-26 90.2 5.4 5e-09 36.5 0.0 6.4 3 1 6 9 9 9 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EGD98708.1 - 1.5e-16 58.8 4.8 0.055 14.1 0.0 7.5 7 0 0 7 7 7 4 Ankyrin repeat SPX PF03105.19 EGD98708.1 - 9.4e-16 58.7 11.6 1.9e-05 24.8 0.1 3.5 1 1 2 3 3 3 3 SPX domain Ank_5 PF13857.6 EGD98708.1 - 7.8e-13 48.4 2.9 0.13 12.6 0.0 5.8 3 2 3 6 6 6 5 Ankyrin repeats (many copies) Ank PF00023.30 EGD98708.1 - 2.2e-08 34.2 8.9 0.15 12.6 0.1 6.9 7 0 0 7 7 7 3 Ankyrin repeat GDPD PF03009.17 EGD98708.1 - 2.2e-07 30.9 0.0 0.0019 18.0 0.0 2.9 2 1 1 3 3 3 2 Glycerophosphoryl diester phosphodiesterase family SKG6 PF08693.10 EGD98709.1 - 2.3e-09 36.5 4.5 4.3e-09 35.6 4.5 1.4 1 0 0 1 1 1 1 Transmembrane alpha-helix domain DUF4448 PF14610.6 EGD98709.1 - 0.0049 16.7 0.0 0.0081 16.0 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) ASFV_J13L PF05568.11 EGD98709.1 - 0.016 15.0 0.9 0.016 15.0 0.9 2.9 3 2 0 3 3 2 0 African swine fever virus J13L protein DUF2207 PF09972.9 EGD98709.1 - 0.1 11.3 0.0 0.14 10.9 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) EphA2_TM PF14575.6 EGD98709.1 - 0.11 13.4 0.2 0.29 12.0 0.0 1.8 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Adeno_E3_CR2 PF02439.15 EGD98709.1 - 0.11 12.2 1.1 0.2 11.4 1.1 1.3 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 TMEM154 PF15102.6 EGD98709.1 - 0.12 12.3 0.2 0.12 12.3 0.2 2.4 2 1 0 2 2 2 0 TMEM154 protein family Phage_holin_2_4 PF16082.5 EGD98709.1 - 0.13 12.0 0.0 0.13 12.0 0.0 1.8 2 0 0 2 2 2 0 Bacteriophage holin family, superfamily II-like DUF1970 PF09301.10 EGD98709.1 - 0.27 11.5 0.0 0.27 11.5 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1970) DUF2615 PF11027.8 EGD98709.1 - 3.7 7.7 0.0 3.7 7.7 0.0 3.8 2 1 0 2 2 1 0 Protein of unknown function (DUF2615) DUF2681 PF10883.8 EGD98709.1 - 4.3 7.8 5.4 2.8 8.4 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) SKG6 PF08693.10 EGD98710.1 - 0.035 13.5 0.4 0.067 12.6 0.4 1.4 1 0 0 1 1 1 0 Transmembrane alpha-helix domain zf-C4H2 PF10146.9 EGD98710.1 - 0.051 13.9 0.0 0.12 12.6 0.0 1.6 1 0 0 1 1 1 0 Zinc finger-containing protein Sugar_tr PF00083.24 EGD98711.1 - 1.5e-98 330.6 19.4 4.1e-98 329.2 19.4 1.6 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EGD98711.1 - 2.4e-30 105.6 21.3 2.4e-30 105.6 21.3 2.2 1 1 0 2 2 2 1 Major Facilitator Superfamily MFS_1 PF07690.16 EGD98712.1 - 6.2e-39 133.9 39.3 6.2e-39 133.9 39.3 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EGD98712.1 - 4.8e-10 38.9 7.8 4.8e-10 38.9 7.8 2.0 2 0 0 2 2 2 1 Sugar (and other) transporter Guanylate_kin PF00625.21 EGD98713.1 - 3.4e-20 72.5 0.0 7.5e-12 45.3 0.0 2.0 1 1 1 2 2 2 2 Guanylate kinase AAA_16 PF13191.6 EGD98713.1 - 0.00048 20.5 0.0 0.00058 20.3 0.0 1.3 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EGD98713.1 - 0.0016 18.7 0.0 0.002 18.4 0.0 1.2 1 0 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.23 EGD98713.1 - 0.0022 18.0 0.0 0.0039 17.3 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_18 PF13238.6 EGD98713.1 - 0.0037 17.8 0.2 0.0055 17.3 0.2 1.6 1 1 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 EGD98713.1 - 0.005 16.7 0.0 0.0078 16.1 0.0 1.3 1 0 0 1 1 1 1 RsgA GTPase AAA_17 PF13207.6 EGD98713.1 - 0.053 14.0 0.5 0.071 13.5 0.5 1.6 1 1 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EGD98713.1 - 0.1 13.0 0.0 0.15 12.5 0.0 1.3 1 0 0 1 1 1 0 RNA helicase AAA_7 PF12775.7 EGD98713.1 - 0.11 12.0 0.0 0.16 11.4 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region NACHT PF05729.12 EGD98713.1 - 0.11 12.4 0.0 0.13 12.2 0.0 1.4 1 1 0 1 1 1 0 NACHT domain Roc PF08477.13 EGD98713.1 - 0.11 12.7 0.0 0.15 12.3 0.0 1.2 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase Cytidylate_kin PF02224.18 EGD98713.1 - 0.16 11.7 0.3 0.3 10.8 0.1 1.5 2 0 0 2 2 2 0 Cytidylate kinase SurE PF01975.17 EGD98713.1 - 0.19 11.5 0.1 5.1 6.8 0.1 2.0 1 1 1 2 2 2 0 Survival protein SurE ABC_tran PF00005.27 EGD98714.1 - 6.7e-46 156.2 0.9 4.7e-22 79.0 0.0 3.1 3 0 0 3 3 3 2 ABC transporter ABC_tran_Xtn PF12848.7 EGD98714.1 - 1.9e-21 75.9 6.5 1.9e-21 75.9 6.5 3.7 5 0 0 5 5 3 1 ABC transporter AAA_21 PF13304.6 EGD98714.1 - 3.2e-17 63.3 1.8 0.0021 17.9 0.0 4.9 5 0 0 5 5 5 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EGD98714.1 - 1.1e-11 44.6 0.2 0.0051 16.3 0.0 4.5 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 EGD98714.1 - 4.6e-06 26.9 0.0 0.012 15.9 0.0 2.8 2 0 0 2 2 2 2 AAA domain MMR_HSR1 PF01926.23 EGD98714.1 - 7.3e-06 26.0 0.0 0.11 12.6 0.0 3.1 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_16 PF13191.6 EGD98714.1 - 9.4e-06 26.1 0.4 0.2 12.0 0.1 2.8 2 0 0 2 2 2 2 AAA ATPase domain AAA_23 PF13476.6 EGD98714.1 - 1.1e-05 26.0 17.7 0.015 15.8 0.0 4.8 5 0 0 5 5 5 2 AAA domain AAA_29 PF13555.6 EGD98714.1 - 2.4e-05 24.0 0.2 0.27 11.0 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_30 PF13604.6 EGD98714.1 - 3.7e-05 23.5 0.0 0.0047 16.7 0.0 3.0 2 1 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 EGD98714.1 - 4.6e-05 23.4 2.2 0.091 12.7 0.1 2.9 3 0 0 3 3 3 2 RsgA GTPase AAA_33 PF13671.6 EGD98714.1 - 6.4e-05 23.1 1.5 0.53 10.4 0.1 3.2 3 1 0 3 3 2 2 AAA domain AAA_18 PF13238.6 EGD98714.1 - 0.00028 21.4 6.0 0.37 11.3 0.0 3.8 5 0 0 5 5 4 2 AAA domain AAA_24 PF13479.6 EGD98714.1 - 0.00034 20.4 1.2 0.88 9.2 0.1 3.0 3 0 0 3 3 2 2 AAA domain AAA_15 PF13175.6 EGD98714.1 - 0.00073 19.3 15.9 0.24 11.0 0.0 5.0 4 1 0 5 5 5 2 AAA ATPase domain AAA_28 PF13521.6 EGD98714.1 - 0.00076 19.8 3.4 0.3 11.3 0.0 2.9 3 0 0 3 3 2 2 AAA domain AAA PF00004.29 EGD98714.1 - 0.0023 18.4 0.1 1.1 9.7 0.1 3.2 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 EGD98714.1 - 0.0033 17.4 0.2 1.3 8.9 0.0 2.8 2 0 0 2 2 2 1 NACHT domain AAA_27 PF13514.6 EGD98714.1 - 0.0036 16.9 0.1 3.7 7.1 0.0 3.2 3 0 0 3 3 3 1 AAA domain Zeta_toxin PF06414.12 EGD98714.1 - 0.011 15.0 2.2 1.8 7.8 0.1 3.1 3 0 0 3 3 3 0 Zeta toxin RNA_helicase PF00910.22 EGD98714.1 - 0.014 15.8 0.1 9.2 6.7 0.0 2.9 3 0 0 3 3 2 0 RNA helicase Dynamin_N PF00350.23 EGD98714.1 - 0.015 15.4 7.2 2 8.4 0.0 4.0 4 1 0 4 4 4 0 Dynamin family Peripla_BP_3 PF13377.6 EGD98714.1 - 0.016 15.5 0.1 25 5.1 0.0 3.4 3 0 0 3 3 3 0 Periplasmic binding protein-like domain AAA_14 PF13173.6 EGD98714.1 - 0.022 14.8 0.6 14 5.8 0.0 3.3 3 0 0 3 3 2 0 AAA domain Rad17 PF03215.15 EGD98714.1 - 0.027 14.4 0.6 1.8 8.4 0.0 3.1 3 0 0 3 3 3 0 Rad17 P-loop domain NTPase_1 PF03266.15 EGD98714.1 - 0.027 14.4 0.1 1.8 8.5 0.1 2.9 2 0 0 2 2 2 0 NTPase cobW PF02492.19 EGD98714.1 - 0.034 13.7 0.6 2.3 7.8 0.5 2.7 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain MobB PF03205.14 EGD98714.1 - 0.034 14.0 0.0 1 9.3 0.0 2.7 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B MeaB PF03308.16 EGD98714.1 - 0.035 13.1 4.2 1.5 7.7 0.0 2.7 3 0 0 3 3 3 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Roc PF08477.13 EGD98714.1 - 0.047 13.9 0.1 8.8 6.6 0.0 2.8 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase SRP54 PF00448.22 EGD98714.1 - 0.048 13.3 0.2 3.2 7.3 0.1 2.7 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain DUF2813 PF11398.8 EGD98714.1 - 0.051 12.8 1.1 0.21 10.8 0.0 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF2813) AAA_5 PF07728.14 EGD98714.1 - 0.095 12.7 0.5 17 5.4 0.0 3.0 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) DUF3385 PF11865.8 EGD98714.1 - 0.11 12.4 0.4 0.35 10.8 0.4 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF3385) AAA_7 PF12775.7 EGD98714.1 - 0.13 11.7 0.1 7.6 6.0 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region DUF4702 PF15774.5 EGD98715.1 - 0.15 11.0 0.8 0.56 9.1 0.2 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4702) Bact_transglu_N PF08379.10 EGD98716.1 - 0.72 10.8 0.0 0.72 10.8 0.0 3.5 4 0 0 4 4 4 0 Bacterial transglutaminase-like N-terminal region DUF1279 PF06916.13 EGD98717.1 - 1.6e-25 89.5 0.0 2.2e-25 89.0 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1279) Innate_immun PF12782.7 EGD98717.1 - 0.18 11.3 0.2 0.25 10.8 0.2 1.2 1 0 0 1 1 1 0 Invertebrate innate immunity transcript family Ribosomal_L3 PF00297.22 EGD98718.1 - 2.8e-16 59.5 4.0 2.1e-14 53.3 0.5 2.1 1 1 1 2 2 2 2 Ribosomal protein L3 Coa1 PF08695.10 EGD98719.1 - 1.1e-43 147.7 0.0 1.3e-43 147.4 0.0 1.1 1 0 0 1 1 1 1 Cytochrome oxidase complex assembly protein 1 DUF4271 PF14093.6 EGD98720.1 - 0.011 15.6 1.1 0.21 11.5 0.1 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4271) DUF3784 PF12650.7 EGD98720.1 - 0.013 15.7 0.1 0.067 13.4 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3784) OPT PF03169.15 EGD98720.1 - 0.069 11.8 1.0 0.088 11.4 1.0 1.1 1 0 0 1 1 1 0 OPT oligopeptide transporter protein DUF4282 PF14110.6 EGD98720.1 - 4.2 8.2 6.7 16 6.3 0.7 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4282) JmjC PF02373.22 EGD98721.1 - 1.3e-07 32.0 0.6 2.9e-06 27.7 0.6 2.6 1 1 0 1 1 1 1 JmjC domain, hydroxylase zf-4CXXC_R1 PF10497.9 EGD98721.1 - 3.2e-06 27.3 8.0 3.2e-06 27.3 8.0 2.5 2 0 0 2 2 2 1 Zinc-finger domain of monoamine-oxidase A repressor R1 Cupin_2 PF07883.11 EGD98721.1 - 0.0094 15.6 0.0 0.02 14.6 0.0 1.4 1 0 0 1 1 1 1 Cupin domain zinc_ribbon_15 PF17032.5 EGD98721.1 - 1.4 9.7 14.9 1.4 9.8 2.0 3.4 3 0 0 3 3 3 0 zinc-ribbon family UbiA PF01040.18 EGD98722.1 - 1.3e-42 145.9 17.9 1.9e-42 145.3 17.9 1.1 1 0 0 1 1 1 1 UbiA prenyltransferase family Flavoprotein PF02441.19 EGD98723.1 - 1.3e-44 151.8 0.0 1.8e-44 151.2 0.0 1.2 1 0 0 1 1 1 1 Flavoprotein Pkinase PF00069.25 EGD98724.1 - 0.00062 19.2 0.0 0.00071 19.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain SUKH_6 PF14568.6 EGD98724.1 - 0.017 15.5 0.0 0.023 15.1 0.0 1.2 1 0 0 1 1 1 0 SMI1-KNR4 cell-wall Glutaredoxin PF00462.24 EGD98725.1 - 5.4e-15 55.4 0.0 9.3e-15 54.6 0.0 1.4 1 0 0 1 1 1 1 Glutaredoxin CCDC23 PF15674.5 EGD98726.1 - 0.97 9.5 15.3 0.46 10.5 6.2 2.7 1 1 2 3 3 3 0 Coiled-coil domain-containing protein 23 DUF1216 PF06746.11 EGD98726.1 - 7.1 6.6 12.0 0.88 9.6 5.0 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF1216) CTP_transf_like PF01467.26 EGD98727.1 - 2.5e-25 89.3 0.0 4.9e-22 78.7 0.0 3.8 3 1 0 4 4 4 2 Cytidylyltransferase-like PRELI PF04707.14 EGD98729.1 - 3.8e-45 153.5 0.4 4.5e-45 153.3 0.4 1.0 1 0 0 1 1 1 1 PRELI-like family PXA PF02194.15 EGD98730.1 - 1.7e-32 112.9 0.0 3.3e-32 111.9 0.0 1.5 1 0 0 1 1 1 1 PXA domain Nexin_C PF08628.12 EGD98730.1 - 2.4e-23 82.8 0.0 8.9e-23 81.0 0.0 2.0 2 0 0 2 2 2 1 Sorting nexin C terminal PX PF00787.24 EGD98730.1 - 1.2e-10 41.3 0.0 2.8e-10 40.2 0.0 1.6 1 0 0 1 1 1 1 PX domain Mito_carr PF00153.27 EGD98731.1 - 1.6e-72 239.5 0.8 2.1e-23 82.0 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 EGD98731.1 - 0.00034 19.9 0.5 0.024 13.8 0.0 3.0 2 1 2 4 4 4 2 Gammaproteobacterial serine protease RRM_1 PF00076.22 EGD98732.1 - 2.5e-12 46.4 0.0 3.4e-12 46.0 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EGD98732.1 - 0.00039 20.4 0.0 0.00054 19.9 0.0 1.2 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif Sedlin_N PF04628.13 EGD98733.1 - 1.7e-15 57.3 0.0 3.2e-15 56.4 0.0 1.4 1 1 0 1 1 1 1 Sedlin, N-terminal conserved region Ribosomal_L18 PF17135.4 EGD98734.1 - 8.2e-95 315.5 2.2 9.1e-95 315.4 2.2 1.0 1 0 0 1 1 1 1 Ribosomal protein 60S L18 and 50S L18e Ribosomal_L27A PF00828.19 EGD98734.1 - 1.6e-05 25.5 0.1 0.0001 23.0 0.1 2.2 1 1 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A AAA_19 PF13245.6 EGD98734.1 - 0.051 13.9 0.0 0.069 13.5 0.0 1.2 1 0 0 1 1 1 0 AAA domain Aldedh PF00171.22 EGD98735.1 - 3.4e-10 39.0 7.0 5.4e-09 35.1 4.9 2.6 1 1 0 2 2 2 2 Aldehyde dehydrogenase family DUF1487 PF07368.11 EGD98735.1 - 0.03 13.8 0.0 0.049 13.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1487) PCI PF01399.27 EGD98736.1 - 3.4e-07 30.7 0.0 8.8e-07 29.4 0.0 1.7 1 0 0 1 1 1 1 PCI domain HrpB1_HrpK PF09613.10 EGD98736.1 - 0.097 12.3 0.0 0.26 10.9 0.0 1.7 1 0 0 1 1 1 0 Bacterial type III secretion protein (HrpB1_HrpK) NifU_N PF01592.16 EGD98737.1 - 2.1e-50 170.2 0.0 2.7e-50 169.8 0.0 1.1 1 0 0 1 1 1 1 NifU-like N terminal domain TSCPD PF12637.7 EGD98737.1 - 0.032 14.5 0.0 0.06 13.6 0.0 1.4 1 0 0 1 1 1 0 TSCPD domain Oxidored_q6 PF01058.22 EGD98738.1 - 8.5e-11 41.8 0.1 1.8e-05 24.5 0.1 2.3 1 1 1 2 2 2 2 NADH ubiquinone oxidoreductase, 20 Kd subunit UDG PF03167.19 EGD98739.1 - 1.9e-22 79.9 0.1 3.9e-22 78.9 0.1 1.5 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily Mucin PF01456.17 EGD98739.1 - 6.4 6.8 26.1 0.22 11.5 16.2 2.2 2 0 0 2 2 2 0 Mucin-like glycoprotein UCH PF00443.29 EGD98741.1 - 3.4e-36 125.1 0.0 4.8e-36 124.6 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP_var PF17807.1 EGD98741.1 - 3.9e-25 87.4 2.0 3.7e-23 81.0 0.4 2.7 2 0 0 2 2 2 2 Variant UBP zinc finger zf-UBP PF02148.19 EGD98741.1 - 1.1e-22 80.1 17.9 1.2e-19 70.3 1.4 3.2 3 0 0 3 3 3 2 Zn-finger in ubiquitin-hydrolases and other protein UCH_1 PF13423.6 EGD98741.1 - 7.3e-16 58.7 0.8 2.7e-13 50.2 0.0 3.4 2 1 0 3 3 3 1 Ubiquitin carboxyl-terminal hydrolase UBA PF00627.31 EGD98741.1 - 1.8e-14 53.3 0.1 4.3e-07 29.7 0.0 2.7 2 0 0 2 2 2 2 UBA/TS-N domain UBA_4 PF14555.6 EGD98741.1 - 0.017 14.9 0.0 0.033 14.0 0.0 1.5 1 0 0 1 1 1 0 UBA-like domain FtsJ PF01728.19 EGD98742.1 - 7.7e-56 189.0 0.0 9.2e-56 188.7 0.0 1.1 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_31 PF13847.6 EGD98742.1 - 1.7e-05 24.7 0.0 0.14 12.0 0.0 2.2 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_23 PF13489.6 EGD98742.1 - 0.00075 19.4 0.0 0.0022 17.9 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain DUF2875 PF11394.8 EGD98742.1 - 0.13 11.1 0.0 0.2 10.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2875) ATG7_N PF16420.5 EGD98743.1 - 3.8e-109 365.0 0.0 4.9e-109 364.6 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-like modifier-activating enzyme ATG7 N-terminus ThiF PF00899.21 EGD98743.1 - 2.3e-42 145.0 0.0 3.3e-42 144.5 0.0 1.1 1 0 0 1 1 1 1 ThiF family ApbA PF02558.16 EGD98743.1 - 0.013 15.2 0.0 0.08 12.6 0.0 2.3 2 1 1 3 3 3 0 Ketopantoate reductase PanE/ApbA Shikimate_DH PF01488.20 EGD98743.1 - 0.027 14.5 0.0 0.066 13.3 0.0 1.6 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase 2-Hacid_dh_C PF02826.19 EGD98743.1 - 0.056 12.8 0.0 0.24 10.7 0.0 1.9 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain dCMP_cyt_deam_1 PF00383.23 EGD98744.1 - 2.8e-28 97.7 2.1 4.4e-28 97.1 2.1 1.3 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 EGD98744.1 - 3.8e-12 46.1 0.5 9.8e-12 44.8 0.3 1.7 2 0 0 2 2 2 1 MafB19-like deaminase AAA_18 PF13238.6 EGD98744.1 - 0.012 16.1 0.0 0.15 12.6 0.1 2.6 2 1 0 2 2 2 0 AAA domain CoaE PF01121.20 EGD98744.1 - 0.085 12.5 0.0 0.14 11.8 0.0 1.4 1 0 0 1 1 1 0 Dephospho-CoA kinase SNAD4 PF18750.1 EGD98744.1 - 0.11 12.6 0.2 1.3 9.2 0.1 2.3 2 0 0 2 2 2 0 Secreted Novel AID/APOBEC-like Deaminase 4 His_biosynth PF00977.21 EGD98745.1 - 2e-46 158.3 0.7 6.4e-46 156.7 0.7 1.8 1 1 0 1 1 1 1 Histidine biosynthesis protein GATase PF00117.28 EGD98745.1 - 2.4e-25 89.4 0.0 3.9e-25 88.7 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I SNO PF01174.19 EGD98745.1 - 8.4e-12 45.3 0.0 3.2e-11 43.4 0.0 1.9 1 1 0 1 1 1 1 SNO glutamine amidotransferase family GATase_3 PF07685.14 EGD98745.1 - 1.3e-09 37.9 0.0 2.9e-09 36.8 0.0 1.5 1 1 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain DJ-1_PfpI PF01965.24 EGD98745.1 - 0.00041 20.2 0.1 0.0069 16.2 0.0 2.3 2 0 0 2 2 2 1 DJ-1/PfpI family Peptidase_S51 PF03575.17 EGD98745.1 - 0.05 13.2 0.0 0.094 12.3 0.0 1.4 1 0 0 1 1 1 0 Peptidase family S51 DNA_pol_E_B PF04042.16 EGD98746.1 - 4.2e-50 170.0 0.1 6.2e-50 169.5 0.1 1.3 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B SHNi-TPR PF10516.9 EGD98747.1 - 3.5e-17 61.6 3.3 7.4e-15 54.1 0.5 2.6 2 0 0 2 2 2 2 SHNi-TPR TPR_12 PF13424.6 EGD98747.1 - 2.2e-07 31.0 3.7 0.0015 18.8 0.9 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat MIT PF04212.18 EGD98747.1 - 0.026 14.6 2.5 0.026 14.6 2.5 2.7 3 0 0 3 3 3 0 MIT (microtubule interacting and transport) domain XhlA PF10779.9 EGD98747.1 - 0.46 10.7 6.7 2.7 8.2 0.6 2.9 2 0 0 2 2 2 0 Haemolysin XhlA Yippee-Mis18 PF03226.14 EGD98748.1 - 7e-21 74.4 0.0 9.3e-21 74.0 0.0 1.1 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly Transp_Tc5_C PF04236.15 EGD98748.1 - 0.022 15.1 0.2 1.3 9.4 0.1 2.3 2 0 0 2 2 2 0 Tc5 transposase C-terminal domain RIG-I_C-RD PF11648.8 EGD98748.1 - 0.031 14.5 2.4 0.33 11.2 2.4 2.0 1 1 0 1 1 1 0 C-terminal domain of RIG-I zf-Sec23_Sec24 PF04810.15 EGD98748.1 - 0.13 12.4 2.1 1.6 8.8 0.3 2.3 2 0 0 2 2 2 0 Sec23/Sec24 zinc finger Thioredoxin PF00085.20 EGD98749.1 - 3.2e-56 187.7 6.9 3.2e-27 94.5 0.0 4.4 4 0 0 4 4 4 4 Thioredoxin Thioredoxin_6 PF13848.6 EGD98749.1 - 1.9e-44 151.7 4.0 1.1e-37 129.7 1.2 3.5 2 1 1 3 3 3 3 Thioredoxin-like domain Thioredoxin_7 PF13899.6 EGD98749.1 - 2.1e-07 31.0 0.0 0.01 16.0 0.0 3.0 3 0 0 3 3 3 2 Thioredoxin-like AhpC-TSA PF00578.21 EGD98749.1 - 3.7e-07 30.1 0.1 0.0038 17.1 0.0 3.0 3 0 0 3 3 3 2 AhpC/TSA family Thioredoxin_8 PF13905.6 EGD98749.1 - 7.8e-07 29.3 1.1 0.074 13.4 0.0 4.1 4 1 1 5 5 5 2 Thioredoxin-like OST3_OST6 PF04756.13 EGD98749.1 - 1.3e-05 24.7 1.2 0.002 17.5 0.0 3.5 2 1 1 4 4 4 1 OST3 / OST6 family, transporter family Thioredoxin_2 PF13098.6 EGD98749.1 - 2.4e-05 24.7 2.4 0.21 12.1 0.3 3.8 3 1 0 3 3 3 2 Thioredoxin-like domain Redoxin PF08534.10 EGD98749.1 - 0.00017 21.3 1.1 0.52 10.0 0.0 2.8 3 0 0 3 3 3 2 Redoxin Thioredoxin_4 PF13462.6 EGD98749.1 - 0.14 12.3 2.8 15 5.7 0.0 3.2 3 1 0 3 3 3 0 Thioredoxin Med14 PF08638.11 EGD98750.1 - 5.9e-32 110.6 0.0 1.4e-31 109.4 0.0 1.6 1 0 0 1 1 1 1 Mediator complex subunit MED14 FAM199X PF15814.5 EGD98750.1 - 0.94 8.5 5.6 2 7.4 5.6 1.5 1 0 0 1 1 1 0 Protein family FAM199X DWNN PF08783.11 EGD98751.1 - 4.7e-10 39.6 1.3 0.00011 22.4 0.1 2.6 1 1 1 2 2 2 2 DWNN domain zf-CCHC_2 PF13696.6 EGD98751.1 - 5.9e-09 35.6 5.0 5.9e-09 35.6 5.0 1.7 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC PF00098.23 EGD98751.1 - 9.1e-05 22.4 1.0 0.00021 21.2 1.0 1.6 1 0 0 1 1 1 1 Zinc knuckle zf-RING_2 PF13639.6 EGD98751.1 - 0.03 14.7 6.2 0.071 13.5 6.2 1.7 1 0 0 1 1 1 0 Ring finger domain DUF3905 PF13045.6 EGD98751.1 - 0.066 13.2 1.0 14 5.8 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3905) zf-CCHC_3 PF13917.6 EGD98751.1 - 0.071 13.1 1.9 0.076 13.0 0.2 2.0 2 0 0 2 2 2 0 Zinc knuckle FYVE_2 PF02318.16 EGD98751.1 - 0.12 12.6 1.8 0.35 11.1 1.8 1.8 1 0 0 1 1 1 0 FYVE-type zinc finger zf-RING_4 PF14570.6 EGD98751.1 - 0.3 10.9 5.8 0.63 9.9 5.8 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-C3HC4 PF00097.25 EGD98751.1 - 1.8 8.5 8.0 4.3 7.3 8.0 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EGD98751.1 - 2 8.6 8.2 6 7.1 8.2 1.9 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.6 EGD98751.1 - 4.6 7.2 15.9 0.089 12.6 8.9 1.8 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Ndc1_Nup PF09531.10 EGD98751.1 - 5.4 5.6 7.1 7.5 5.1 7.1 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF1272 PF06906.11 EGD98751.1 - 7.8 6.7 10.5 0.31 11.1 4.7 1.7 2 0 0 2 2 1 0 Protein of unknown function (DUF1272) Presenilin PF01080.17 EGD98751.1 - 9.3 4.9 11.6 21 3.7 11.6 1.6 1 0 0 1 1 1 0 Presenilin Nucleoporin_C PF03177.14 EGD98752.1 - 5.4e-170 567.0 10.6 6.5e-170 566.8 10.6 1.1 1 0 0 1 1 1 1 Non-repetitive/WGA-negative nucleoporin C-terminal Nucleoporin_N PF08801.11 EGD98752.1 - 2e-55 188.3 0.0 2.9e-55 187.8 0.0 1.2 1 0 0 1 1 1 1 Nup133 N terminal like HABP4_PAI-RBP1 PF04774.15 EGD98753.1 - 0.0057 17.5 2.9 0.0079 17.0 2.9 1.3 1 0 0 1 1 1 1 Hyaluronan / mRNA binding family OST3_OST6 PF04756.13 EGD98754.1 - 4e-102 341.5 0.0 5.2e-102 341.1 0.0 1.0 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family HXXEE PF13787.6 EGD98754.1 - 0.0067 17.2 1.9 0.0075 17.1 0.2 1.8 2 0 0 2 2 2 1 Protein of unknown function with HXXEE motif Thioredoxin PF00085.20 EGD98754.1 - 0.036 14.0 0.0 0.057 13.4 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin MerC PF03203.14 EGD98754.1 - 0.22 12.0 4.8 3.5 8.1 0.3 3.1 3 0 0 3 3 3 0 MerC mercury resistance protein PRKG1_interact PF15898.5 EGD98755.1 - 2.8e-05 25.0 10.4 2.8e-05 25.0 10.4 3.3 3 1 0 3 3 2 1 cGMP-dependent protein kinase interacting domain GAS PF13851.6 EGD98755.1 - 0.00016 21.1 16.8 0.00072 19.0 16.8 2.0 1 1 0 1 1 1 1 Growth-arrest specific micro-tubule binding PI3K_P85_iSH2 PF16454.5 EGD98755.1 - 0.0008 19.0 16.1 0.018 14.6 16.1 2.5 1 1 0 1 1 1 1 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain DivIC PF04977.15 EGD98755.1 - 0.0026 17.5 7.5 0.023 14.5 0.1 3.0 2 1 0 2 2 2 1 Septum formation initiator HALZ PF02183.18 EGD98755.1 - 0.0061 16.8 2.5 0.96 9.7 0.0 3.2 2 1 0 2 2 2 1 Homeobox associated leucine zipper Sec34 PF04136.15 EGD98755.1 - 0.008 16.1 7.7 0.008 16.1 7.7 2.1 1 1 1 2 2 2 1 Sec34-like family Phlebovirus_NSM PF07246.11 EGD98755.1 - 0.0094 15.3 7.3 0.0094 15.3 7.3 1.7 2 0 0 2 2 2 1 Phlebovirus nonstructural protein NS-M bZIP_1 PF00170.21 EGD98755.1 - 0.015 15.3 0.3 0.015 15.3 0.3 3.3 3 1 0 4 4 3 0 bZIP transcription factor CENP-F_leu_zip PF10473.9 EGD98755.1 - 0.046 13.8 19.1 0.64 10.0 19.0 2.7 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TolA_bind_tri PF16331.5 EGD98755.1 - 0.061 13.4 15.4 1.1 9.4 10.3 3.2 1 1 1 2 2 2 0 TolA binding protein trimerisation Mod_r PF07200.13 EGD98755.1 - 0.13 12.4 18.5 0.068 13.3 4.9 2.4 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein FlaC_arch PF05377.11 EGD98755.1 - 0.37 11.2 10.0 0.68 10.4 0.4 3.6 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) BLOC1_2 PF10046.9 EGD98755.1 - 0.81 10.0 9.3 2.6 8.4 4.1 2.7 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Cnn_1N PF07989.11 EGD98755.1 - 0.82 9.9 12.5 1.3 9.3 1.2 3.1 1 1 2 3 3 3 0 Centrosomin N-terminal motif 1 UPF1_Zn_bind PF09416.10 EGD98755.1 - 0.93 9.4 3.1 1.3 9.0 1.6 1.9 1 1 1 2 2 2 0 RNA helicase (UPF2 interacting domain) Fez1 PF06818.15 EGD98755.1 - 1.1 9.6 18.8 4.2 7.8 18.8 2.1 1 1 0 1 1 1 0 Fez1 ADIP PF11559.8 EGD98755.1 - 1.2 9.3 20.1 0.18 11.9 5.8 2.7 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding DMPK_coil PF08826.10 EGD98755.1 - 1.2 9.3 11.6 0.74 10.0 4.6 3.0 2 1 0 2 2 2 0 DMPK coiled coil domain like APG6_N PF17675.1 EGD98755.1 - 1.2 9.7 20.3 2.9 8.4 4.4 2.8 1 1 1 2 2 2 0 Apg6 coiled-coil region ZapB PF06005.12 EGD98755.1 - 1.4 9.4 20.5 1.3 9.5 4.0 4.1 1 1 2 3 3 3 0 Cell division protein ZapB DUF3450 PF11932.8 EGD98755.1 - 1.6 8.0 15.5 2.9 7.1 1.9 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) DUF2730 PF10805.8 EGD98755.1 - 1.8 8.7 5.0 1.4 9.0 1.7 2.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2730) DUF4200 PF13863.6 EGD98755.1 - 2.3 8.7 14.6 11 6.4 14.3 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4200) Cep57_CLD_2 PF14197.6 EGD98755.1 - 2.4 8.3 14.3 0.32 11.1 2.2 3.5 1 1 3 4 4 4 0 Centrosome localisation domain of PPC89 CorA PF01544.18 EGD98755.1 - 3.4 6.9 8.8 5.7 6.2 8.5 1.5 1 1 0 1 1 1 0 CorA-like Mg2+ transporter protein FUSC PF04632.12 EGD98755.1 - 4.5 5.7 4.6 7 5.0 4.6 1.3 1 0 0 1 1 1 0 Fusaric acid resistance protein family IFP_35_N PF07334.13 EGD98755.1 - 6.8 6.8 8.9 15 5.7 0.1 4.0 3 1 2 5 5 4 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus YabA PF06156.13 EGD98755.1 - 8.4 7.1 13.7 3 8.5 2.8 3.1 1 1 1 2 2 2 0 Initiation control protein YabA DUF2968 PF11180.8 EGD98755.1 - 9.5 5.8 21.7 1.6 8.3 7.0 2.6 2 1 1 3 3 2 0 Protein of unknown function (DUF2968) ArAE_2_N PF10337.9 EGD98755.1 - 9.7 5.1 7.2 14 4.6 7.2 1.2 1 0 0 1 1 1 0 Putative ER transporter, 6TM, N-terminal Complex1_LYR PF05347.15 EGD98756.1 - 0.0018 18.3 0.2 0.0031 17.5 0.2 1.4 1 0 0 1 1 1 1 Complex 1 protein (LYR family) zinc_ribbon_6 PF14599.6 EGD98757.1 - 5e-25 87.3 0.5 7.6e-25 86.7 0.5 1.3 1 0 0 1 1 1 1 Zinc-ribbon Stc1 PF12898.7 EGD98757.1 - 0.12 13.0 0.1 0.19 12.3 0.1 1.3 1 0 0 1 1 1 0 Stc1 domain MFMR_assoc PF16596.5 EGD98757.1 - 5.5 7.5 9.5 0.29 11.6 3.3 2.0 2 1 0 2 2 2 0 Disordered region downstream of MFMR CENP-B_dimeris PF09026.10 EGD98757.1 - 7.2 7.1 9.2 13 6.3 9.2 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Rrn6 PF10214.9 EGD98758.1 - 1.2e-216 722.1 5.7 1.5e-216 721.8 5.7 1.0 1 0 0 1 1 1 1 RNA polymerase I-specific transcription-initiation factor Spindle_Spc25 PF08234.12 EGD98759.1 - 1.6e-24 85.9 0.1 1.3e-23 83.0 0.0 2.5 2 0 0 2 2 2 1 Chromosome segregation protein Spc25 V_ATPase_I PF01496.19 EGD98759.1 - 1.4 6.7 9.1 1.8 6.4 9.1 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF334 PF03904.13 EGD98759.1 - 1.5 8.3 9.0 2 7.9 9.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF334) ERM PF00769.19 EGD98759.1 - 2.6 7.8 20.7 3.8 7.3 20.7 1.2 1 0 0 1 1 1 0 Ezrin/radixin/moesin family Ku_C PF03730.14 EGD98759.1 - 3 8.6 8.0 1.3 9.8 3.5 2.1 1 1 1 2 2 2 0 Ku70/Ku80 C-terminal arm Calpain_III PF01067.22 EGD98759.1 - 4.4 7.6 6.0 6.7 7.0 6.0 1.2 1 0 0 1 1 1 0 Calpain large subunit, domain III LMBR1 PF04791.16 EGD98759.1 - 5.3 5.8 5.2 6.1 5.6 5.2 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF4407 PF14362.6 EGD98759.1 - 6.2 6.1 11.2 8.7 5.6 11.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Atg14 PF10186.9 EGD98759.1 - 6.3 5.8 15.6 8.9 5.3 15.6 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 FUSC PF04632.12 EGD98759.1 - 7.4 5.0 7.2 9.8 4.6 7.2 1.3 1 0 0 1 1 1 0 Fusaric acid resistance protein family WD40 PF00400.32 EGD98760.1 - 2.8e-24 84.9 10.2 2e-08 34.7 0.3 6.8 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EGD98760.1 - 8.2e-15 54.9 0.8 0.00013 22.2 0.4 4.4 2 1 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EGD98760.1 - 0.00077 19.4 0.0 0.16 11.8 0.0 2.8 1 1 2 3 3 3 1 Eukaryotic translation initiation factor eIF2A Cytochrom_D1 PF02239.16 EGD98760.1 - 0.00079 18.1 0.0 0.0027 16.3 0.0 1.7 1 1 0 1 1 1 1 Cytochrome D1 heme domain Nbas_N PF15492.6 EGD98760.1 - 0.0011 18.3 0.3 2.3 7.5 0.0 3.4 2 2 2 4 4 4 2 Neuroblastoma-amplified sequence, N terminal Nup160 PF11715.8 EGD98760.1 - 0.0026 16.5 0.2 0.66 8.5 0.0 2.3 2 0 0 2 2 2 2 Nucleoporin Nup120/160 PQQ_3 PF13570.6 EGD98760.1 - 0.006 17.0 0.5 2 9.0 0.0 3.7 3 1 0 3 3 3 1 PQQ-like domain Hira PF07569.11 EGD98760.1 - 0.0086 15.8 0.0 5.1 6.7 0.0 3.1 2 1 1 3 3 3 1 TUP1-like enhancer of split Ge1_WD40 PF16529.5 EGD98760.1 - 0.064 12.2 0.3 7.2 5.5 0.0 3.1 1 1 2 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Nucleoporin_N PF08801.11 EGD98760.1 - 0.12 11.1 0.1 1.4 7.6 0.1 2.4 2 1 0 2 2 2 0 Nup133 N terminal like WD40_like PF17005.5 EGD98760.1 - 0.17 11.2 0.0 19 4.5 0.0 2.6 2 1 1 3 3 3 0 WD40-like domain Ribosomal_L32p PF01783.23 EGD98761.1 - 2.6e-14 53.2 6.5 3.9e-14 52.7 6.5 1.2 1 0 0 1 1 1 1 Ribosomal L32p protein family DZR PF12773.7 EGD98761.1 - 0.0054 16.7 0.8 0.0086 16.1 0.8 1.3 1 0 0 1 1 1 1 Double zinc ribbon zinc-ribbons_6 PF07191.12 EGD98761.1 - 0.033 14.2 0.6 0.047 13.7 0.6 1.2 1 0 0 1 1 1 0 zinc-ribbons OrfB_Zn_ribbon PF07282.11 EGD98761.1 - 0.047 13.6 0.8 0.087 12.8 0.8 1.6 1 0 0 1 1 1 0 Putative transposase DNA-binding domain zf-ribbon_3 PF13248.6 EGD98761.1 - 0.16 11.5 5.1 0.4 10.2 5.3 1.6 1 1 0 1 1 1 0 zinc-ribbon domain CpXC PF14353.6 EGD98761.1 - 0.24 11.4 1.6 1.6 8.8 1.6 2.0 1 1 1 2 2 2 0 CpXC protein Zn-ribbon_8 PF09723.10 EGD98761.1 - 0.54 10.4 4.5 7.1 6.8 0.4 2.2 1 1 1 2 2 2 0 Zinc ribbon domain Zn_Tnp_IS1595 PF12760.7 EGD98761.1 - 4.3 7.4 6.4 3.3 7.8 0.3 2.3 1 1 1 2 2 2 0 Transposase zinc-ribbon domain zf-XS PF03470.14 EGD98761.1 - 6.7 7.1 8.7 19 5.6 0.2 3.2 3 0 0 3 3 3 0 XS zinc finger domain Septin PF00735.18 EGD98762.1 - 1.4e-112 375.6 0.7 1.6e-112 375.4 0.7 1.0 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 EGD98762.1 - 7.6e-08 32.4 0.0 1.5e-07 31.5 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase AIG1 PF04548.16 EGD98762.1 - 5e-06 26.0 0.0 8.5e-06 25.2 0.0 1.4 1 0 0 1 1 1 1 AIG1 family RsgA_GTPase PF03193.16 EGD98762.1 - 5.3e-05 23.2 0.5 0.00027 20.9 0.1 2.1 2 0 0 2 2 2 1 RsgA GTPase GTP_EFTU PF00009.27 EGD98762.1 - 0.00028 20.5 0.8 0.016 14.8 0.1 2.4 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 EGD98762.1 - 0.00051 20.1 0.3 1.5 8.9 0.0 2.5 1 1 0 2 2 2 2 Dynamin family NB-ARC PF00931.22 EGD98762.1 - 0.0033 16.6 0.1 0.0058 15.8 0.1 1.3 1 0 0 1 1 1 1 NB-ARC domain AAA_16 PF13191.6 EGD98762.1 - 0.005 17.2 0.0 0.012 16.1 0.0 1.9 1 1 0 1 1 1 1 AAA ATPase domain AAA_7 PF12775.7 EGD98762.1 - 0.0059 16.1 0.1 0.031 13.8 0.0 2.1 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_22 PF13401.6 EGD98762.1 - 0.009 16.3 0.0 0.018 15.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.27 EGD98762.1 - 0.016 15.7 0.3 0.035 14.6 0.3 1.6 1 1 0 1 1 1 0 ABC transporter G-alpha PF00503.20 EGD98762.1 - 0.051 12.7 0.6 0.39 9.8 0.1 1.9 1 1 1 2 2 2 0 G-protein alpha subunit Gtr1_RagA PF04670.12 EGD98762.1 - 0.079 12.3 0.1 0.65 9.3 0.0 2.1 2 0 0 2 2 2 0 Gtr1/RagA G protein conserved region T2SSE PF00437.20 EGD98762.1 - 0.085 11.9 0.1 0.3 10.1 0.0 1.9 2 0 0 2 2 2 0 Type II/IV secretion system protein FtsK_SpoIIIE PF01580.18 EGD98762.1 - 0.087 12.2 0.0 0.15 11.4 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_29 PF13555.6 EGD98762.1 - 0.087 12.6 0.3 0.41 10.4 0.0 2.2 3 0 0 3 3 3 0 P-loop containing region of AAA domain Roc PF08477.13 EGD98762.1 - 0.11 12.7 0.0 0.23 11.7 0.0 1.5 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase Guanylate_kin PF00625.21 EGD98763.1 - 6.2e-62 208.5 0.0 7.5e-62 208.2 0.0 1.0 1 0 0 1 1 1 1 Guanylate kinase AAA_16 PF13191.6 EGD98763.1 - 1.7e-06 28.5 0.1 2.4e-06 28.0 0.1 1.6 1 1 0 1 1 1 1 AAA ATPase domain MMR_HSR1 PF01926.23 EGD98763.1 - 7.6e-06 26.0 0.0 1.2e-05 25.4 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_18 PF13238.6 EGD98763.1 - 0.00012 22.7 0.2 0.0005 20.6 0.2 2.0 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EGD98763.1 - 0.00013 22.1 0.4 0.0027 17.9 0.4 2.2 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EGD98763.1 - 0.00017 21.9 0.0 0.00036 20.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.27 EGD98763.1 - 0.00084 19.9 0.0 0.0018 18.8 0.0 1.5 2 0 0 2 2 2 1 ABC transporter AAA_28 PF13521.6 EGD98763.1 - 0.00093 19.5 0.1 0.002 18.4 0.0 1.6 2 0 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 EGD98763.1 - 0.0012 18.8 0.0 0.002 18.1 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_30 PF13604.6 EGD98763.1 - 0.0038 17.0 0.0 0.0075 16.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 EGD98763.1 - 0.0051 16.5 0.1 0.01 15.5 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_7 PF12775.7 EGD98763.1 - 0.0058 16.2 0.0 0.0091 15.5 0.0 1.2 1 0 0 1 1 1 1 P-loop containing dynein motor region RNA_helicase PF00910.22 EGD98763.1 - 0.0094 16.3 0.0 0.015 15.6 0.0 1.4 1 0 0 1 1 1 1 RNA helicase NACHT PF05729.12 EGD98763.1 - 0.0095 15.9 0.0 0.015 15.2 0.0 1.3 1 0 0 1 1 1 1 NACHT domain AAA_14 PF13173.6 EGD98763.1 - 0.0098 15.9 0.0 0.018 15.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain ATPase_2 PF01637.18 EGD98763.1 - 0.017 15.1 0.0 0.027 14.4 0.0 1.4 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_24 PF13479.6 EGD98763.1 - 0.02 14.6 0.1 0.092 12.5 0.0 1.9 2 1 0 2 2 2 0 AAA domain AAA PF00004.29 EGD98763.1 - 0.02 15.3 0.0 0.14 12.6 0.0 2.0 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 EGD98763.1 - 0.022 14.7 0.1 0.13 12.2 0.0 2.2 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) Rad17 PF03215.15 EGD98763.1 - 0.027 14.4 0.0 0.037 14.0 0.0 1.2 1 0 0 1 1 1 0 Rad17 P-loop domain NTPase_1 PF03266.15 EGD98763.1 - 0.046 13.6 0.1 0.084 12.8 0.1 1.6 1 1 0 1 1 1 0 NTPase Adeno_IVa2 PF02456.15 EGD98763.1 - 0.048 12.4 0.0 0.074 11.8 0.0 1.2 1 0 0 1 1 1 0 Adenovirus IVa2 protein T2SSE PF00437.20 EGD98763.1 - 0.053 12.6 0.0 0.11 11.5 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein DUF2075 PF09848.9 EGD98763.1 - 0.056 12.7 0.0 0.1 11.8 0.0 1.7 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) cobW PF02492.19 EGD98763.1 - 0.066 12.8 0.0 0.18 11.3 0.0 1.6 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_23 PF13476.6 EGD98763.1 - 0.086 13.3 0.1 0.22 12.0 0.0 1.6 2 0 0 2 2 2 0 AAA domain AAA_17 PF13207.6 EGD98763.1 - 0.1 13.0 0.5 1.5 9.2 0.0 2.2 2 0 0 2 2 2 0 AAA domain KAP_NTPase PF07693.14 EGD98763.1 - 0.14 11.4 0.0 0.14 11.4 0.0 1.1 1 0 0 1 1 1 0 KAP family P-loop domain dNK PF01712.19 EGD98763.1 - 0.14 12.0 0.1 1.3 8.8 0.0 2.1 2 0 0 2 2 2 0 Deoxynucleoside kinase Sigma54_activat PF00158.26 EGD98763.1 - 0.15 11.7 0.0 0.25 11.0 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain GRAB PF10375.9 EGD98764.1 - 5.2e-08 32.5 0.2 1.1e-07 31.4 0.2 1.6 1 0 0 1 1 1 1 GRIP-related Arf-binding domain Golgin_A5 PF09787.9 EGD98764.1 - 0.0055 16.2 59.1 0.53 9.7 26.0 3.2 1 1 2 3 3 3 3 Golgin subfamily A member 5 APC_N_CC PF16689.5 EGD98764.1 - 0.0099 15.9 4.1 0.0099 15.9 4.1 4.2 4 0 0 4 4 4 1 Coiled-coil N-terminus of APC, dimerisation domain Fez1 PF06818.15 EGD98764.1 - 0.011 16.1 54.8 0.014 15.9 6.7 3.4 2 1 0 3 3 3 0 Fez1 Baculo_PEP_C PF04513.12 EGD98764.1 - 0.038 14.0 14.0 1.7 8.7 7.0 3.2 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus HALZ PF02183.18 EGD98764.1 - 0.077 13.2 20.0 3.9 7.8 0.0 6.2 4 1 2 6 6 6 0 Homeobox associated leucine zipper FAM184 PF15665.5 EGD98764.1 - 0.11 12.2 49.6 0.15 11.8 12.3 3.3 1 1 2 3 3 3 0 Family with sequence similarity 184, A and B FliJ PF02050.16 EGD98764.1 - 0.24 11.6 45.5 0.085 13.1 16.9 3.7 1 1 2 3 3 3 0 Flagellar FliJ protein DUF3584 PF12128.8 EGD98764.1 - 0.45 8.0 49.1 0.54 7.7 34.9 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) Spc7 PF08317.11 EGD98764.1 - 2.4 7.0 55.2 4.3 6.1 18.1 3.0 1 1 2 3 3 3 0 Spc7 kinetochore protein CCCAP PF15964.5 EGD98764.1 - 2.9 6.1 52.3 3.5 5.8 23.5 2.1 1 1 1 2 2 2 0 Centrosomal colon cancer autoantigen protein family DUF641 PF04859.12 EGD98764.1 - 4.2 7.7 39.6 2 8.8 5.7 4.7 2 1 3 5 5 5 0 Plant protein of unknown function (DUF641) NPV_P10 PF05531.12 EGD98764.1 - 4.5 7.8 13.0 11 6.6 0.1 4.5 2 2 3 5 5 5 0 Nucleopolyhedrovirus P10 protein ATG16 PF08614.11 EGD98764.1 - 4.7 7.4 66.2 0.095 12.9 19.9 4.2 1 1 3 4 4 4 0 Autophagy protein 16 (ATG16) Fib_alpha PF08702.10 EGD98764.1 - 5.6 7.1 29.7 0.69 10.1 2.0 3.8 1 1 1 3 3 3 0 Fibrinogen alpha/beta chain family Filament PF00038.21 EGD98764.1 - 8.7 5.8 50.9 25 4.3 25.5 3.2 1 1 1 2 2 2 0 Intermediate filament protein NFACT-R_1 PF05670.13 EGD98766.1 - 1.7e-25 89.8 0.0 2e-25 89.6 0.0 1.0 1 0 0 1 1 1 1 NFACT protein RNA binding domain DAO PF01266.24 EGD98768.1 - 1.3e-49 169.7 0.0 2.3e-49 168.9 0.0 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase DAO_C PF16901.5 EGD98768.1 - 2e-43 147.3 0.1 3.4e-43 146.5 0.1 1.4 1 0 0 1 1 1 1 C-terminal domain of alpha-glycerophosphate oxidase FAD_binding_2 PF00890.24 EGD98768.1 - 4.6e-09 35.9 0.8 0.00036 19.7 0.8 2.3 2 0 0 2 2 2 2 FAD binding domain FAD_oxidored PF12831.7 EGD98768.1 - 1.1e-06 28.3 0.8 9.3e-05 21.9 0.7 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EGD98768.1 - 6.3e-05 22.3 0.7 0.00044 19.6 0.7 2.0 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EGD98768.1 - 0.00048 19.3 0.3 0.015 14.4 0.1 2.2 2 0 0 2 2 2 1 Glucose inhibited division protein A 3HCDH_N PF02737.18 EGD98768.1 - 0.0043 17.0 0.1 0.0093 15.9 0.1 1.6 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_8 PF13450.6 EGD98768.1 - 0.0071 16.5 0.3 0.026 14.7 0.3 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 EGD98768.1 - 0.015 14.0 0.3 0.027 13.2 0.3 1.4 1 0 0 1 1 1 0 HI0933-like protein Methyltransf_34 PF11312.8 EGD98768.1 - 0.027 13.7 0.1 0.042 13.1 0.1 1.2 1 0 0 1 1 1 0 Putative SAM-dependent methyltransferase Pyr_redox PF00070.27 EGD98768.1 - 0.044 14.3 0.4 0.16 12.6 0.1 2.1 2 0 0 2 2 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EGD98768.1 - 0.053 12.8 0.0 0.39 9.9 0.0 2.0 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 EGD98768.1 - 0.055 12.7 1.0 0.31 10.2 1.1 2.0 1 1 0 1 1 1 0 FAD binding domain Lycopene_cycl PF05834.12 EGD98768.1 - 0.1 11.7 0.0 0.69 8.9 0.1 2.0 2 0 0 2 2 2 0 Lycopene cyclase protein CCT PF06203.14 EGD98768.1 - 0.18 11.9 0.2 11 6.1 0.0 2.4 2 0 0 2 2 2 0 CCT motif p450 PF00067.22 EGD98769.1 - 3.7e-64 217.2 0.0 4.3e-64 217.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DASH_Dad2 PF08654.10 EGD98770.1 - 9e-28 96.6 0.2 1.1e-27 96.3 0.2 1.1 1 0 0 1 1 1 1 DASH complex subunit Dad2 Rogdi_lz PF10259.9 EGD98770.1 - 0.0076 15.7 0.2 0.0083 15.6 0.2 1.1 1 0 0 1 1 1 1 Rogdi leucine zipper containing protein APG6_N PF17675.1 EGD98770.1 - 0.015 15.8 0.0 0.021 15.3 0.0 1.2 1 0 0 1 1 1 0 Apg6 coiled-coil region NPV_P10 PF05531.12 EGD98770.1 - 0.023 15.1 0.9 0.037 14.5 0.9 1.5 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein Seryl_tRNA_N PF02403.22 EGD98770.1 - 0.036 14.3 0.8 0.036 14.3 0.8 1.6 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Shugoshin_N PF07558.11 EGD98771.1 - 7.4e-19 67.3 2.0 1.6e-18 66.3 2.0 1.6 1 0 0 1 1 1 1 Shugoshin N-terminal coiled-coil region Shugoshin_C PF07557.11 EGD98771.1 - 1.7e-10 40.5 8.9 1.7e-10 40.5 8.9 2.4 2 0 0 2 2 2 1 Shugoshin C terminus PPI_Ypi1 PF07491.11 EGD98772.1 - 4.3e-22 77.7 1.7 4.3e-22 77.7 1.7 1.9 1 1 1 2 2 2 1 Protein phosphatase inhibitor YL1 PF05764.13 EGD98772.1 - 0.003 17.7 1.5 0.003 17.7 1.5 1.2 1 0 0 1 1 1 1 YL1 nuclear protein Glypican PF01153.19 EGD98772.1 - 0.35 9.7 2.1 0.4 9.5 2.1 1.1 1 0 0 1 1 1 0 Glypican PBP1_TM PF14812.6 EGD98772.1 - 0.53 10.7 4.4 0.8 10.1 4.4 1.3 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal ALAD PF00490.21 EGD98773.1 - 5.3e-121 403.7 0.0 6e-121 403.5 0.0 1.0 1 0 0 1 1 1 1 Delta-aminolevulinic acid dehydratase Mac_assoc PF16628.5 EGD98774.1 - 1.4e-61 208.0 12.0 1.4e-61 208.0 12.0 3.9 3 1 0 3 3 3 1 Unstructured region on maltose acetyltransferase Hexapep PF00132.24 EGD98774.1 - 9.8e-12 44.1 6.2 1.1e-07 31.3 0.3 3.4 2 1 2 4 4 4 3 Bacterial transferase hexapeptide (six repeats) Zn_clus PF00172.18 EGD98774.1 - 3.4e-10 39.9 8.8 5.9e-10 39.1 8.8 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Mac PF12464.8 EGD98774.1 - 7.1e-10 39.0 0.0 1.6e-09 37.9 0.0 1.6 1 0 0 1 1 1 1 Maltose acetyltransferase Hexapep_2 PF14602.6 EGD98774.1 - 9.6e-07 28.5 5.4 8.4e-06 25.4 0.4 2.8 2 1 1 3 3 3 1 Hexapeptide repeat of succinyl-transferase CagX PF03524.15 EGD98774.1 - 0.29 10.8 2.8 0.73 9.5 2.8 1.6 1 0 0 1 1 1 0 Conjugal transfer protein FAD_binding_3 PF01494.19 EGD98775.1 - 4e-16 59.2 0.0 5.3e-16 58.8 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain SE PF08491.10 EGD98775.1 - 0.00087 18.4 0.0 0.0015 17.7 0.0 1.4 1 1 0 1 1 1 1 Squalene epoxidase Amino_oxidase PF01593.24 EGD98775.1 - 0.0056 16.0 0.7 0.16 11.2 0.4 2.7 3 0 0 3 3 3 1 Flavin containing amine oxidoreductase DAO PF01266.24 EGD98775.1 - 0.0067 16.1 0.5 0.24 10.9 0.0 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EGD98775.1 - 0.021 15.0 0.1 0.065 13.5 0.1 1.8 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 EGD98775.1 - 0.081 12.0 1.4 0.17 10.9 0.8 1.7 2 0 0 2 2 2 0 FAD binding domain Pyr_redox_2 PF07992.14 EGD98775.1 - 0.11 11.7 0.0 0.29 10.3 0.0 1.6 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase CRM1_C PF08767.11 EGD98776.1 - 1.4e-135 451.6 5.0 1.4e-135 451.6 5.0 2.9 3 0 0 3 3 3 1 CRM1 C terminal Xpo1 PF08389.12 EGD98776.1 - 5.8e-42 143.3 9.1 1.9e-41 141.6 6.6 3.3 2 1 1 3 3 3 1 Exportin 1-like protein CRM1_repeat_2 PF18784.1 EGD98776.1 - 9.3e-34 114.9 4.1 4.9e-33 112.6 4.1 2.4 2 0 0 2 2 2 1 CRM1 / Exportin repeat 2 CRM1_repeat_3 PF18787.1 EGD98776.1 - 2.9e-29 100.9 0.7 2.9e-29 100.9 0.7 2.8 3 0 0 3 3 3 1 CRM1 / Exportin repeat 3 CRM1_repeat PF18777.1 EGD98776.1 - 6.3e-20 70.4 1.3 1.4e-19 69.2 1.3 1.7 1 0 0 1 1 1 1 Chromosome region maintenance or exportin repeat IBN_N PF03810.19 EGD98776.1 - 5.5e-13 48.6 0.2 2.3e-12 46.6 0.2 2.2 1 0 0 1 1 1 1 Importin-beta N-terminal domain DUF3385 PF11865.8 EGD98776.1 - 0.0026 17.7 0.2 0.3 11.0 0.0 4.0 3 0 0 3 3 3 1 Domain of unknown function (DUF3385) HD_assoc PF13286.6 EGD98776.1 - 0.018 15.5 3.2 9.5 6.8 0.0 4.1 4 0 0 4 4 4 0 Phosphohydrolase-associated domain CIAPIN1 PF05093.13 EGD98777.1 - 6.5e-42 142.1 3.6 6.5e-42 142.1 3.6 2.0 2 0 0 2 2 2 1 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis DRE2_N PF16803.5 EGD98777.1 - 6.1e-34 117.1 0.2 2.9e-33 114.9 0.0 2.0 2 0 0 2 2 2 1 Fe-S cluster assembly protein DRE2 N-terminus Rft-1 PF04506.13 EGD98778.1 - 3e-129 432.1 13.6 3.6e-129 431.8 13.6 1.0 1 0 0 1 1 1 1 Rft protein Polysacc_synt_3 PF13440.6 EGD98778.1 - 0.012 14.9 20.2 0.026 13.7 7.9 3.1 1 1 1 2 2 2 0 Polysaccharide biosynthesis protein Polysacc_synt PF01943.17 EGD98778.1 - 2 7.7 29.8 0.75 9.1 10.5 3.3 3 1 0 3 3 3 0 Polysaccharide biosynthesis protein Rep_fac-A_C PF08646.10 EGD98779.1 - 6.3e-48 162.2 8.1 1e-46 158.3 4.8 2.3 2 0 0 2 2 2 2 Replication factor-A C terminal domain REPA_OB_2 PF16900.5 EGD98779.1 - 5e-35 119.3 0.2 1.1e-34 118.2 0.1 1.7 2 0 0 2 2 2 1 Replication protein A OB domain Rep-A_N PF04057.12 EGD98779.1 - 1.4e-19 70.0 0.1 3.4e-19 68.8 0.0 1.7 2 0 0 2 2 2 1 Replication factor-A protein 1, N-terminal domain tRNA_anti-codon PF01336.25 EGD98779.1 - 1.4e-12 47.4 0.1 1.5e-07 31.3 0.0 4.0 3 1 1 4 4 4 2 OB-fold nucleic acid binding domain CDC24_OB3 PF17244.2 EGD98779.1 - 0.0074 16.0 0.9 0.11 12.2 0.4 2.5 3 0 0 3 3 3 1 Cell division control protein 24, OB domain 3 Ribosomal_L37ae PF01780.19 EGD98779.1 - 0.026 14.6 0.5 0.068 13.3 0.5 1.7 1 0 0 1 1 1 0 Ribosomal L37ae protein family DUF4503 PF14951.6 EGD98779.1 - 0.037 12.5 0.3 0.058 11.8 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4503) DUF223 PF02721.14 EGD98779.1 - 0.14 12.5 0.1 1.7 9.0 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function DUF223 DUF2293 PF10056.9 EGD98780.1 - 2.2e-29 101.5 1.1 5.4e-29 100.3 0.1 2.2 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2293) MHYT PF03707.16 EGD98782.1 - 6.7e-15 55.0 25.9 2e-09 37.4 1.1 4.6 4 1 0 4 4 4 2 Bacterial signalling protein N terminal repeat Pax2_C PF12403.8 EGD98782.1 - 0.051 13.7 0.0 0.14 12.3 0.0 1.8 1 0 0 1 1 1 0 Paired-box protein 2 C terminal HMA PF00403.26 EGD98783.1 - 1.4e-15 57.4 0.2 1.7e-15 57.2 0.2 1.1 1 0 0 1 1 1 1 Heavy-metal-associated domain Vps4_C PF09336.10 EGD98783.1 - 0.00065 19.6 0.0 0.0008 19.4 0.0 1.3 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain Fer2_BFD PF04324.15 EGD98783.1 - 0.1 13.0 0.2 0.37 11.2 0.1 1.9 2 0 0 2 2 2 0 BFD-like [2Fe-2S] binding domain Tcp11 PF05794.13 EGD98784.1 - 3.9e-105 352.5 0.1 3.9e-105 352.5 0.1 1.9 3 0 0 3 3 3 1 T-complex protein 11 PXA PF02194.15 EGD98785.1 - 1.2e-44 152.5 0.1 6.7e-44 150.0 0.1 2.4 2 0 0 2 2 2 1 PXA domain Nexin_C PF08628.12 EGD98785.1 - 5.7e-28 97.7 0.0 2e-27 96.0 0.0 2.1 1 0 0 1 1 1 1 Sorting nexin C terminal PX PF00787.24 EGD98785.1 - 8.5e-19 67.6 0.1 2e-18 66.4 0.1 1.6 1 0 0 1 1 1 1 PX domain RGS PF00615.19 EGD98785.1 - 2.6e-11 43.8 0.0 6.4e-11 42.6 0.0 1.7 1 0 0 1 1 1 1 Regulator of G protein signaling domain WD40 PF00400.32 EGD98787.1 - 4.7e-18 65.2 5.8 0.002 18.9 0.0 5.7 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EGD98787.1 - 2.8e-07 30.8 0.0 0.019 15.2 0.0 4.5 2 1 3 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EGD98787.1 - 0.0054 15.7 0.6 0.1 11.6 0.0 2.7 2 1 1 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein tRNA-synt_1g PF09334.11 EGD98788.1 - 2.1e-148 494.3 0.0 3.1e-148 493.7 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 EGD98788.1 - 1.3e-07 30.3 0.0 6.9e-05 21.3 0.0 3.5 3 1 1 4 4 4 2 tRNA synthetases class I (I, L, M and V) BRF1 PF07741.13 EGD98788.1 - 0.27 11.6 6.6 0.59 10.5 6.6 1.5 1 0 0 1 1 1 0 Brf1-like TBP-binding domain PepSY PF03413.19 EGD98788.1 - 0.31 11.6 3.8 15 6.2 0.0 2.7 2 0 0 2 2 2 0 Peptidase propeptide and YPEB domain Laminin_EGF PF00053.24 EGD98788.1 - 0.35 11.1 3.8 0.6 10.3 3.8 1.4 1 0 0 1 1 1 0 Laminin EGF domain AP3D1 PF06375.11 EGD98788.1 - 0.72 10.1 7.3 1.2 9.4 7.3 1.2 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 Elongin_A PF06881.11 EGD98788.1 - 5.3 7.6 8.4 4 8.0 5.9 2.0 2 0 0 2 2 2 0 RNA polymerase II transcription factor SIII (Elongin) subunit A Yae1_N PF09811.9 EGD98789.1 - 4.7e-07 29.4 3.6 7.5e-07 28.8 3.6 1.3 1 0 0 1 1 1 1 Essential protein Yae1, N terminal WD40 PF00400.32 EGD98790.1 - 2e-31 107.5 17.7 3.9e-08 33.8 0.1 8.1 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EGD98790.1 - 1.4e-11 44.5 4.9 0.01 16.1 0.1 4.8 4 2 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Coatomer_WDAD PF04053.14 EGD98790.1 - 0.15 11.0 0.4 0.26 10.3 0.4 1.3 1 0 0 1 1 1 0 Coatomer WD associated region bZIP_1 PF00170.21 EGD98792.1 - 9.6e-05 22.4 9.1 0.0027 17.8 4.2 2.3 1 1 1 2 2 2 2 bZIP transcription factor bZIP_2 PF07716.15 EGD98792.1 - 0.00012 22.1 10.6 0.00023 21.2 10.6 1.5 1 0 0 1 1 1 1 Basic region leucine zipper Pox_A_type_inc PF04508.12 EGD98792.1 - 0.016 15.0 1.2 0.016 15.0 1.2 1.8 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat DUF2796 PF10986.8 EGD98792.1 - 0.049 13.6 0.1 0.07 13.1 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2796) Macoilin PF09726.9 EGD98792.1 - 0.097 11.2 4.6 0.14 10.7 4.6 1.1 1 0 0 1 1 1 0 Macoilin family RRM_1 PF00076.22 EGD98793.1 - 6.6e-23 80.3 0.0 9e-23 79.9 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EGD98793.1 - 0.00062 19.8 0.0 0.0012 19.0 0.0 1.5 1 1 0 1 1 1 1 RNA recognition motif RRM_3 PF08777.11 EGD98793.1 - 0.09 12.8 0.0 0.18 11.9 0.0 1.5 1 0 0 1 1 1 0 RNA binding motif ChaC PF04752.12 EGD98794.1 - 7e-49 166.3 0.2 8.5e-48 162.8 0.2 1.9 1 1 0 1 1 1 1 ChaC-like protein RHS PF03527.14 EGD98794.1 - 0.12 12.1 0.2 11 5.8 0.0 2.4 2 0 0 2 2 2 0 RHS protein EF-hand_1 PF00036.32 EGD98795.1 - 4.9e-19 66.4 11.0 2.8e-07 29.6 0.1 4.3 3 1 0 3 3 3 3 EF hand EF-hand_8 PF13833.6 EGD98795.1 - 2.7e-17 62.3 10.1 4.1e-09 36.1 0.1 4.1 3 1 1 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.6 EGD98795.1 - 5.5e-16 57.1 4.1 0.00044 20.0 0.1 3.7 3 0 0 3 3 3 3 EF-hand domain EF-hand_5 PF13202.6 EGD98795.1 - 7.6e-14 50.5 9.3 3.9e-05 23.0 0.4 4.0 3 1 0 3 3 3 3 EF hand EF-hand_7 PF13499.6 EGD98795.1 - 1.3e-13 51.1 7.2 4.3e-05 23.9 5.6 3.5 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_14 PF17959.1 EGD98795.1 - 0.035 14.4 0.1 0.091 13.1 0.0 1.7 2 1 0 2 2 2 0 EF-hand domain G6PD_C PF02781.16 EGD98796.1 - 4.8e-105 350.9 0.0 7.5e-105 350.3 0.0 1.2 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, C-terminal domain G6PD_N PF00479.22 EGD98796.1 - 7e-23 82.2 0.0 1.9e-22 80.7 0.0 1.7 2 0 0 2 2 2 1 Glucose-6-phosphate dehydrogenase, NAD binding domain Ribosomal_L12_N PF16320.5 EGD98797.1 - 3.7 7.3 11.8 7.1 6.4 11.8 1.5 1 0 0 1 1 1 0 Ribosomal protein L7/L12 dimerisation domain FAM176 PF14851.6 EGD98798.1 - 0.11 12.2 3.3 0.13 12.0 3.3 1.1 1 0 0 1 1 1 0 FAM176 family Cytomega_UL84 PF06284.11 EGD98798.1 - 0.72 8.2 3.4 0.76 8.2 3.4 1.1 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein TMEM119 PF15724.5 EGD98798.1 - 1 9.4 4.7 1.1 9.3 4.7 1.1 1 0 0 1 1 1 0 TMEM119 family DNA_pol_phi PF04931.13 EGD98798.1 - 7.2 4.6 6.2 7.8 4.5 6.2 1.0 1 0 0 1 1 1 0 DNA polymerase phi MFS_1 PF07690.16 EGD98799.1 - 5.6e-45 153.8 56.4 5.6e-44 150.5 55.7 2.6 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EGD98799.1 - 1.2e-18 66.9 20.7 2.5e-18 65.9 20.7 1.5 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 EGD98799.1 - 7.6e-10 38.2 15.5 7.6e-10 38.2 15.5 3.5 4 1 0 4 4 4 1 Sugar (and other) transporter OATP PF03137.20 EGD98799.1 - 2.5 6.3 21.2 0.25 9.6 4.1 3.6 2 2 2 4 4 4 0 Organic Anion Transporter Polypeptide (OATP) family CBS PF00571.28 EGD98802.1 - 4.9e-05 23.7 0.0 3.4 8.2 0.0 3.3 1 1 2 3 3 3 3 CBS domain Mito_carr PF00153.27 EGD98803.1 - 4.1e-48 161.3 7.0 3.3e-19 68.6 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein SnoaL_2 PF12680.7 EGD98804.1 - 0.12 13.0 0.0 0.28 11.8 0.0 1.6 1 0 0 1 1 1 0 SnoaL-like domain Peptidase_S10 PF00450.22 EGD98805.1 - 2.8e-08 33.6 0.0 3.9e-08 33.1 0.0 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase CCT_2 PF09425.10 EGD98805.1 - 0.017 15.0 0.5 0.044 13.7 0.1 1.9 2 0 0 2 2 2 0 Divergent CCT motif DUF2207 PF09972.9 EGD98805.1 - 0.12 11.1 0.0 0.15 10.8 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) RNA_Me_trans PF04252.13 EGD98806.1 - 1.1e-70 237.3 0.0 1.2e-70 237.1 0.0 1.0 1 0 0 1 1 1 1 Predicted SAM-dependent RNA methyltransferase Endosulfine PF04667.17 EGD98807.1 - 3.5e-28 97.5 0.3 7.5e-28 96.5 0.3 1.5 1 0 0 1 1 1 1 cAMP-regulated phosphoprotein/endosulfine conserved region ICE2 PF08426.10 EGD98808.1 - 3.6e-150 500.6 18.3 4.1e-150 500.4 18.3 1.0 1 0 0 1 1 1 1 ICE2 Fungal_trans PF04082.18 EGD98809.1 - 6.8e-13 48.3 0.0 6.8e-13 48.3 0.0 2.3 3 0 0 3 3 3 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EGD98809.1 - 4.3e-07 29.9 17.5 8.6e-07 29.0 17.5 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Coilin_N PF15862.5 EGD98809.1 - 0.0016 18.3 0.6 0.0028 17.4 0.6 1.4 1 0 0 1 1 1 1 Coilin N-terminus DUF4834 PF16118.5 EGD98809.1 - 0.0076 17.2 2.2 0.021 15.8 0.9 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF4834) Ctr PF04145.15 EGD98809.1 - 0.038 14.6 0.7 0.081 13.5 0.7 1.7 1 0 0 1 1 1 0 Ctr copper transporter family TERB2 PF15101.6 EGD98809.1 - 0.065 13.3 5.1 0.099 12.7 5.1 1.3 1 0 0 1 1 1 0 Telomere-associated protein TERB2 EOS1 PF12326.8 EGD98809.1 - 0.12 12.4 0.6 0.29 11.1 0.6 1.7 1 0 0 1 1 1 0 N-glycosylation protein Spt20 PF12090.8 EGD98809.1 - 0.16 11.5 22.5 0.28 10.7 22.5 1.4 1 0 0 1 1 1 0 Spt20 family Roughex PF06020.11 EGD98809.1 - 0.26 10.3 8.5 0.43 9.6 8.5 1.3 1 0 0 1 1 1 0 Drosophila roughex protein TFIIA PF03153.13 EGD98809.1 - 0.4 10.6 17.7 0.63 10.0 17.7 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Hid1 PF12722.7 EGD98809.1 - 0.59 8.2 11.6 0.81 7.7 11.6 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Macoilin PF09726.9 EGD98809.1 - 1.3 7.5 11.4 0.61 8.6 9.2 1.4 2 0 0 2 2 2 0 Macoilin family Peptidase_S64 PF08192.11 EGD98809.1 - 7.9 4.8 13.1 12 4.2 13.1 1.2 1 0 0 1 1 1 0 Peptidase family S64 Lin-8 PF03353.15 EGD98809.1 - 8.9 5.8 16.1 14 5.1 16.1 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Peptidase_M41 PF01434.18 EGD98810.1 - 3.7e-67 225.9 0.9 5.5e-67 225.3 0.0 1.8 2 0 0 2 2 2 1 Peptidase family M41 AAA PF00004.29 EGD98810.1 - 7.2e-42 143.0 0.0 2.2e-41 141.4 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EGD98810.1 - 7.5e-12 44.9 0.1 2.2e-11 43.4 0.1 1.8 1 0 0 1 1 1 1 AAA+ lid domain FtsH_ext PF06480.15 EGD98810.1 - 6.1e-09 36.2 1.0 1.5e-08 35.0 0.0 2.2 2 0 0 2 2 2 1 FtsH Extracellular AAA_5 PF07728.14 EGD98810.1 - 0.0025 17.8 0.0 0.013 15.5 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EGD98810.1 - 0.0026 18.2 0.2 0.14 12.5 0.0 3.1 3 0 0 3 3 3 1 AAA ATPase domain AAA_22 PF13401.6 EGD98810.1 - 0.0066 16.7 0.2 1.1 9.5 0.0 3.4 4 0 0 4 4 4 1 AAA domain RuvB_N PF05496.12 EGD98810.1 - 0.018 14.8 0.0 0.05 13.3 0.0 1.7 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain TIP49 PF06068.13 EGD98810.1 - 0.02 14.1 0.0 0.044 13.0 0.0 1.5 1 0 0 1 1 1 0 TIP49 P-loop domain IstB_IS21 PF01695.17 EGD98810.1 - 0.027 14.2 0.0 0.064 13.0 0.0 1.6 1 1 0 1 1 1 0 IstB-like ATP binding protein RNA_pol_Rpc4 PF05132.14 EGD98810.1 - 0.16 12.4 7.8 0.069 13.6 0.6 2.4 2 0 0 2 2 2 0 RNA polymerase III RPC4 TIP120 PF08623.10 EGD98810.1 - 0.21 11.3 1.2 14 5.4 0.7 2.4 2 0 0 2 2 2 0 TATA-binding protein interacting (TIP20) AAA_17 PF13207.6 EGD98810.1 - 2.1 8.8 0.0 2.1 8.8 0.0 3.4 3 1 1 4 4 4 0 AAA domain DUF1295 PF06966.12 EGD98811.1 - 1.4e-39 136.0 7.8 2.2e-39 135.4 7.8 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) ICMT PF04140.14 EGD98811.1 - 0.27 11.7 0.0 0.27 11.7 0.0 2.4 2 2 0 2 2 2 0 Isoprenylcysteine carboxyl methyltransferase (ICMT) family Topoisom_bac PF01131.20 EGD98812.1 - 6e-100 335.1 0.0 7.7e-100 334.8 0.0 1.1 1 0 0 1 1 1 1 DNA topoisomerase Toprim PF01751.22 EGD98812.1 - 9.2e-16 58.0 0.0 2.2e-15 56.8 0.0 1.7 1 0 0 1 1 1 1 Toprim domain DUF730 PF05325.11 EGD98813.1 - 0.0063 16.5 0.7 0.11 12.6 0.1 3.0 2 0 0 2 2 2 1 Protein of unknown function (DUF730) HEPN_AbiU2 PF18734.1 EGD98813.1 - 0.032 13.8 0.2 0.23 10.9 0.2 2.5 1 0 0 1 1 1 0 AbiU2 Baculo_PEP_C PF04513.12 EGD98813.1 - 0.042 13.9 21.0 0.45 10.5 4.5 4.9 1 1 5 6 6 6 0 Baculovirus polyhedron envelope protein, PEP, C terminus Csm1_N PF18504.1 EGD98813.1 - 0.23 11.8 8.9 52 4.3 0.8 6.1 3 2 1 5 5 5 0 Csm1 N-terminal domain Mrpl_C PF18502.1 EGD98813.1 - 0.66 10.3 3.6 1.8 8.9 0.3 3.0 2 0 0 2 2 2 0 54S ribosomal protein L8 C-terminal domain SlyX PF04102.12 EGD98813.1 - 0.93 10.2 21.0 4.7 7.9 0.3 7.5 5 3 2 7 7 7 0 SlyX ROS_MUCR PF05443.11 EGD98813.1 - 1 9.4 10.6 1.3 9.1 1.2 3.5 3 1 1 4 4 4 0 ROS/MUCR transcriptional regulator protein MIP-T3_C PF17749.1 EGD98813.1 - 1.9 8.4 25.3 12 5.9 0.1 4.8 3 1 1 4 4 4 0 Microtubule-binding protein MIP-T3 C-terminal region DUF4149 PF13664.6 EGD98814.1 - 4.9e-26 91.0 0.9 4.9e-26 91.0 0.9 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4149) Ku_PK_bind PF08785.11 EGD98815.1 - 2.7e-35 121.1 0.3 7.2e-35 119.7 0.3 1.8 1 0 0 1 1 1 1 Ku C terminal domain like Ku PF02735.16 EGD98815.1 - 4.6e-28 98.3 0.0 8.2e-28 97.5 0.0 1.3 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain Ku_N PF03731.15 EGD98815.1 - 1.8e-13 50.8 0.0 3.7e-13 49.7 0.0 1.5 1 0 0 1 1 1 1 Ku70/Ku80 N-terminal alpha/beta domain VWA PF00092.28 EGD98815.1 - 0.003 17.8 0.0 0.012 15.9 0.0 2.0 1 1 0 1 1 1 1 von Willebrand factor type A domain PX PF00787.24 EGD98816.1 - 3.6e-16 59.2 0.0 1e-15 57.7 0.0 1.7 2 0 0 2 2 2 1 PX domain SIP1 PF04938.12 EGD98817.1 - 1.9e-11 44.1 0.0 2.2e-09 37.3 0.0 2.3 2 0 0 2 2 2 2 Survival motor neuron (SMN) interacting protein 1 (SIP1) tRNA-synt_2 PF00152.20 EGD98818.1 - 2.6e-65 220.6 0.1 3.5e-65 220.1 0.1 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 EGD98818.1 - 2.2e-06 27.5 0.0 4.3e-06 26.6 0.0 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain Hydrolase_6 PF13344.6 EGD98819.1 - 6.8e-25 87.1 0.0 1.2e-24 86.3 0.0 1.4 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EGD98819.1 - 1.3e-15 57.2 0.0 6.7e-15 54.9 0.0 2.1 2 0 0 2 2 2 1 HAD-hyrolase-like Hydrolase PF00702.26 EGD98819.1 - 0.15 12.3 0.0 9 6.5 0.0 3.0 2 1 1 3 3 3 0 haloacid dehalogenase-like hydrolase F-box-like PF12937.7 EGD98820.1 - 8.8e-11 41.5 0.4 2.5e-10 40.1 0.4 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EGD98820.1 - 0.078 12.9 0.4 0.27 11.2 0.0 2.1 2 0 0 2 2 2 0 F-box domain COP-gamma_platf PF08752.10 EGD98821.1 - 4.8e-60 202.1 1.8 9.2e-60 201.2 1.8 1.5 1 0 0 1 1 1 1 Coatomer gamma subunit appendage platform subdomain Adaptin_N PF01602.20 EGD98821.1 - 1.2e-59 202.3 0.0 1.7e-59 201.8 0.0 1.2 1 0 0 1 1 1 1 Adaptin N terminal region Coatomer_g_Cpla PF16381.5 EGD98821.1 - 2.2e-32 111.6 0.4 9.6e-32 109.5 0.1 2.1 2 0 0 2 2 2 1 Coatomer subunit gamma-1 C-terminal appendage platform HEAT_2 PF13646.6 EGD98821.1 - 8.9e-15 54.9 0.0 8e-13 48.6 0.0 2.6 2 0 0 2 2 2 1 HEAT repeats Cnd1 PF12717.7 EGD98821.1 - 4.2e-05 23.6 0.5 0.00066 19.7 0.1 2.4 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 EGD98821.1 - 0.00072 19.6 3.8 0.27 11.6 0.3 4.0 4 0 0 4 4 3 1 HEAT repeat Alpha_adaptin_C PF02296.16 EGD98821.1 - 0.0015 18.7 0.0 0.0041 17.3 0.0 1.7 1 0 0 1 1 1 1 Alpha adaptin AP2, C-terminal domain HEAT_EZ PF13513.6 EGD98821.1 - 0.05 14.1 0.4 0.14 12.7 0.4 1.8 1 0 0 1 1 1 0 HEAT-like repeat HEAT_PBS PF03130.16 EGD98821.1 - 0.071 13.8 0.2 1.5 9.7 0.1 3.3 3 0 0 3 3 3 0 PBS lyase HEAT-like repeat Coatomer_b_Cpla PF14806.6 EGD98821.1 - 0.13 12.3 0.0 1.1 9.3 0.0 2.5 3 0 0 3 3 3 0 Coatomer beta subunit appendage platform MRP-S35 PF10246.9 EGD98821.1 - 0.13 12.3 0.1 14 5.7 0.0 2.6 2 0 0 2 2 2 0 Mitochondrial ribosomal protein MRP-S35 Adaptin_N PF01602.20 EGD98822.1 - 1.8e-41 142.3 0.1 2.5e-41 141.9 0.1 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 EGD98822.1 - 2.8e-05 24.2 1.9 0.0065 16.5 0.1 3.0 3 0 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EGD98822.1 - 0.14 12.6 0.0 1.3 9.4 0.0 2.3 2 0 0 2 2 2 0 HEAT repeats DUF5010 PF16402.5 EGD98822.1 - 0.14 10.9 0.0 0.18 10.6 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5010) Phosducin PF02114.16 EGD98823.1 - 4.6e-15 55.3 0.1 5.6e-15 55.0 0.1 1.1 1 0 0 1 1 1 1 Phosducin Exog_C PF18026.1 EGD98823.1 - 0.99 9.5 6.2 7.6 6.7 2.6 2.4 2 0 0 2 2 2 0 Endo/exonuclease (EXOG) C-terminal domain bZIP_1 PF00170.21 EGD98824.1 - 8.6e-06 25.8 12.6 1.3e-05 25.2 12.6 1.3 1 0 0 1 1 1 1 bZIP transcription factor SHE3 PF17078.5 EGD98824.1 - 2.6e-05 24.0 6.3 3.9e-05 23.5 6.3 1.2 1 0 0 1 1 1 1 SWI5-dependent HO expression protein 3 V_ATPase_I PF01496.19 EGD98824.1 - 0.0025 15.9 0.3 0.0031 15.5 0.3 1.1 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family CCDC106 PF15794.5 EGD98824.1 - 0.013 15.3 7.2 0.017 14.8 4.5 1.9 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 106 bZIP_Maf PF03131.17 EGD98824.1 - 0.018 15.5 10.7 0.032 14.8 10.7 1.4 1 0 0 1 1 1 0 bZIP Maf transcription factor Tmemb_cc2 PF10267.9 EGD98824.1 - 0.031 13.4 2.8 0.047 12.8 2.8 1.3 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein RR_TM4-6 PF06459.12 EGD98824.1 - 0.058 13.2 1.8 0.084 12.7 1.8 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 GAS PF13851.6 EGD98824.1 - 0.058 12.7 6.6 0.087 12.2 6.6 1.2 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Pox_A_type_inc PF04508.12 EGD98824.1 - 0.084 12.8 1.7 0.18 11.7 1.7 1.5 1 0 0 1 1 1 0 Viral A-type inclusion protein repeat TMF_TATA_bd PF12325.8 EGD98824.1 - 0.13 12.5 4.4 0.23 11.7 4.4 1.4 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding PAP1 PF08601.10 EGD98824.1 - 0.23 11.1 0.1 0.23 11.1 0.1 2.4 2 1 0 2 2 2 0 Transcription factor PAP1 bZIP_2 PF07716.15 EGD98824.1 - 0.38 10.9 16.7 0.61 10.2 15.6 1.8 1 1 1 2 2 2 0 Basic region leucine zipper CDC45 PF02724.14 EGD98824.1 - 1.2 7.4 7.0 1.5 7.0 7.0 1.1 1 0 0 1 1 1 0 CDC45-like protein Pkinase PF00069.25 EGD98825.1 - 6e-26 91.4 0.0 7.6e-26 91.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD98825.1 - 7.8e-14 51.6 0.0 1e-13 51.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EGD98825.1 - 5.3e-09 35.3 0.0 7.5e-09 34.8 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EGD98825.1 - 0.00025 21.0 0.0 0.0016 18.4 0.0 2.0 1 1 0 2 2 2 1 Phosphotransferase enzyme family Kelch_5 PF13854.6 EGD98826.1 - 1.5e-34 117.4 6.3 4.5e-09 36.1 0.1 6.5 6 0 0 6 6 6 6 Kelch motif Kelch_4 PF13418.6 EGD98826.1 - 9.2e-31 105.6 12.2 4.3e-08 33.0 1.3 6.5 5 1 1 6 6 6 6 Galactose oxidase, central domain Kelch_3 PF13415.6 EGD98826.1 - 3e-29 100.7 22.9 1.3e-07 31.8 0.6 7.2 8 0 0 8 8 8 5 Galactose oxidase, central domain Kelch_1 PF01344.25 EGD98826.1 - 4.6e-28 96.5 4.5 2e-12 46.5 0.2 6.1 6 0 0 6 6 6 4 Kelch motif Kelch_6 PF13964.6 EGD98826.1 - 6.4e-26 89.7 8.7 8.2e-11 41.8 0.5 6.3 4 1 2 6 6 6 5 Kelch motif Kelch_2 PF07646.15 EGD98826.1 - 4.4e-23 80.3 7.6 1.1e-08 34.7 0.2 6.4 6 0 0 6 6 6 4 Kelch motif YabA PF06156.13 EGD98826.1 - 0.0091 16.6 2.7 0.0091 16.6 2.7 7.6 4 2 3 7 7 7 1 Initiation control protein YabA DUF4396 PF14342.6 EGD98828.1 - 3.3e-45 153.9 3.1 4.7e-45 153.4 3.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4396) Raptor_N PF14538.6 EGD98829.1 - 8.1e-63 210.8 0.0 1.6e-62 209.8 0.0 1.5 1 0 0 1 1 1 1 Raptor N-terminal CASPase like domain WD40 PF00400.32 EGD98829.1 - 3.2e-05 24.6 10.5 0.4 11.6 0.1 6.3 5 0 0 5 5 5 1 WD domain, G-beta repeat HEAT PF02985.22 EGD98829.1 - 0.0049 17.0 0.6 1.8 9.1 0.0 3.5 2 0 0 2 2 2 1 HEAT repeat HEAT_2 PF13646.6 EGD98829.1 - 0.011 16.1 0.0 0.036 14.5 0.0 1.9 1 0 0 1 1 1 0 HEAT repeats Atx10homo_assoc PF09759.9 EGD98829.1 - 0.025 14.6 0.0 0.059 13.4 0.0 1.6 1 0 0 1 1 1 0 Spinocerebellar ataxia type 10 protein domain BBS2_Mid PF14783.6 EGD98829.1 - 0.027 14.5 0.2 1.2 9.2 0.1 2.6 1 1 1 2 2 2 0 Ciliary BBSome complex subunit 2, middle region zf-RING_2 PF13639.6 EGD98831.1 - 4.7e-13 49.2 5.4 7.4e-13 48.6 5.4 1.3 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 EGD98831.1 - 3.9e-09 36.1 2.5 3.9e-09 36.1 2.5 1.8 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 EGD98831.1 - 5.9e-09 35.6 4.8 9.6e-09 34.9 4.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EGD98831.1 - 1e-08 35.3 3.1 2.2e-08 34.3 3.1 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 EGD98831.1 - 1.9e-08 34.1 4.0 3e-08 33.4 4.0 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) PA PF02225.22 EGD98831.1 - 8.5e-08 32.1 0.0 2.2e-07 30.8 0.0 1.7 1 0 0 1 1 1 1 PA domain zf-RING_5 PF14634.6 EGD98831.1 - 1.5e-07 31.3 3.1 2.3e-07 30.7 3.1 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 EGD98831.1 - 3.9e-06 26.6 3.1 5.8e-06 26.1 3.1 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EGD98831.1 - 6.8e-06 26.0 2.2 1.1e-05 25.3 0.4 2.1 1 1 1 2 2 2 1 RING-type zinc-finger Prok-RING_4 PF14447.6 EGD98831.1 - 0.0014 18.4 3.1 0.0024 17.7 3.1 1.3 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 EGD98831.1 - 0.0015 18.5 1.1 0.0028 17.7 1.1 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.5 EGD98831.1 - 0.05 13.2 3.0 0.098 12.3 3.0 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type FANCL_C PF11793.8 EGD98831.1 - 0.071 13.3 3.0 0.18 12.0 3.0 1.7 1 1 0 1 1 1 0 FANCL C-terminal domain zf-C3HC4_4 PF15227.6 EGD98831.1 - 0.096 12.9 4.4 0.2 11.8 4.4 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING RINGv PF12906.7 EGD98831.1 - 0.37 11.0 4.3 0.75 10.0 4.3 1.6 1 0 0 1 1 1 0 RING-variant domain zf-RING_4 PF14570.6 EGD98831.1 - 0.46 10.3 3.2 0.83 9.5 3.2 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain PHD PF00628.29 EGD98831.1 - 0.62 10.0 3.1 1.1 9.2 3.1 1.5 1 0 0 1 1 1 0 PHD-finger zf-RING-like PF08746.11 EGD98831.1 - 2 8.8 3.7 3.8 7.9 3.7 1.5 1 0 0 1 1 1 0 RING-like domain SelK_SelG PF10961.8 EGD98831.1 - 4.3 8.0 0.0 4.3 8.0 0.0 4.4 3 2 0 4 4 3 0 Selenoprotein SelK_SelG EI24 PF07264.11 EGD98832.1 - 4.6e-13 49.8 4.5 6.8e-13 49.2 4.5 1.2 1 0 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) Chitin_bind_1 PF00187.19 EGD98833.1 - 0.0026 18.2 17.5 0.0026 18.2 17.5 1.8 2 0 0 2 2 2 1 Chitin recognition protein FAD_binding_3 PF01494.19 EGD98835.1 - 2.7e-13 49.9 0.0 8.2e-13 48.3 0.0 1.7 1 1 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 EGD98835.1 - 4.5e-05 23.6 0.0 0.00013 22.1 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EGD98835.1 - 6.5e-05 22.3 0.1 0.0023 17.2 0.1 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EGD98835.1 - 0.00031 20.4 0.3 0.00048 19.8 0.3 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Trp_halogenase PF04820.14 EGD98835.1 - 0.0013 17.7 0.9 0.0016 17.4 0.1 1.5 2 0 0 2 2 2 1 Tryptophan halogenase DUF1967 PF09269.11 EGD98835.1 - 0.016 15.1 0.7 0.11 12.4 0.2 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF1967) MCRA PF06100.11 EGD98835.1 - 0.025 13.4 0.1 0.038 12.8 0.1 1.2 1 0 0 1 1 1 0 MCRA family AlaDh_PNT_C PF01262.21 EGD98835.1 - 0.12 11.7 0.0 0.19 11.0 0.0 1.2 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain GIDA PF01134.22 EGD98835.1 - 0.21 10.7 0.2 0.3 10.1 0.2 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A FAD_oxidored PF12831.7 EGD98835.1 - 0.25 10.6 1.0 0.42 9.9 1.0 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase FHA PF00498.26 EGD98837.1 - 1.9e-16 60.2 0.0 3.6e-16 59.3 0.0 1.5 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 EGD98837.1 - 0.00019 21.7 0.0 0.00047 20.4 0.0 1.6 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain Med21 PF11221.8 EGD98837.1 - 0.8 10.0 22.8 0.063 13.5 7.7 3.4 3 0 0 3 3 3 0 Subunit 21 of Mediator complex Jnk-SapK_ap_N PF09744.9 EGD98837.1 - 0.87 9.8 17.8 0.73 10.1 6.4 2.7 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 LMBR1 PF04791.16 EGD98837.1 - 2.7 6.8 10.5 0.24 10.3 0.8 2.1 2 0 0 2 2 2 0 LMBR1-like membrane protein DUF5327 PF17261.2 EGD98837.1 - 5.5 7.8 18.3 6.8 7.5 4.3 3.9 3 1 0 3 3 3 0 Family of unknown function (DUF5327) Sigma70_ner PF04546.13 EGD98837.1 - 7.3 6.4 18.5 3.6 7.4 1.5 2.4 2 0 0 2 2 2 0 Sigma-70, non-essential region GrpE PF01025.19 EGD98837.1 - 9.4 5.9 20.0 0.29 10.8 7.5 2.4 2 0 0 2 2 2 0 GrpE Romo1 PF10247.9 EGD98838.1 - 5.4e-28 97.1 16.6 7.2e-28 96.7 16.6 1.2 1 0 0 1 1 1 1 Reactive mitochondrial oxygen species modulator 1 Tim17 PF02466.19 EGD98838.1 - 0.025 14.9 5.5 0.03 14.7 5.5 1.2 1 0 0 1 1 1 0 Tim17/Tim22/Tim23/Pmp24 family Gly-zipper_OmpA PF13436.6 EGD98838.1 - 0.15 11.9 3.5 0.78 9.6 0.4 2.4 2 0 0 2 2 2 0 Glycine-zipper domain LysM PF01476.20 EGD98839.1 - 9e-21 73.7 0.1 7.4e-07 29.1 0.0 3.2 3 0 0 3 3 3 3 LysM domain Pex14_N PF04695.13 EGD98839.1 - 0.031 14.9 5.9 0.083 13.5 2.4 2.1 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region HTH_23 PF13384.6 EGD98839.1 - 0.032 14.0 0.0 0.12 12.2 0.0 1.8 2 0 0 2 2 2 0 Homeodomain-like domain DUF1153 PF06627.11 EGD98839.1 - 0.15 12.2 0.0 0.44 10.7 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1153) UPF0203 PF05254.12 EGD98839.1 - 0.31 11.3 2.8 3.4 8.0 0.3 2.8 2 1 0 2 2 2 0 Uncharacterised protein family (UPF0203) MGC-24 PF05283.11 EGD98840.1 - 2.5 8.5 6.1 4.4 7.8 6.1 1.3 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin LRR_8 PF13855.6 EGD98841.1 - 2.3e-09 36.9 0.8 5.7e-09 35.6 0.8 1.6 1 0 0 1 1 1 1 Leucine rich repeat LRR_4 PF12799.7 EGD98841.1 - 5e-06 26.8 1.2 1.2e-05 25.6 0.5 2.1 2 0 0 2 2 2 1 Leucine Rich repeats (2 copies) Ribosomal_S14 PF00253.21 EGD98843.1 - 1.3e-20 72.9 0.7 3.2e-20 71.6 0.2 1.9 3 0 0 3 3 3 1 Ribosomal protein S14p/S29e ATP-synt_J PF04911.12 EGD98844.1 - 1.9e-14 52.9 0.2 3.1e-14 52.3 0.2 1.3 1 0 0 1 1 1 1 ATP synthase j chain DASH_Spc19 PF08287.11 EGD98845.1 - 2.8e-50 170.3 3.8 3.9e-50 169.8 3.8 1.2 1 0 0 1 1 1 1 Spc19 LPD30 PF18850.1 EGD98845.1 - 0.066 13.0 0.0 0.1 12.3 0.0 1.3 1 0 0 1 1 1 0 Large polyvalent protein associated domain 30 Rsm22 PF09243.10 EGD98846.1 - 6.8e-29 101.0 0.0 3.9e-28 98.5 0.0 2.1 1 1 0 1 1 1 1 Mitochondrial small ribosomal subunit Rsm22 Methyltransf_23 PF13489.6 EGD98846.1 - 0.075 12.9 0.0 0.15 11.9 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain BNR_2 PF13088.6 EGD98847.1 - 3.5e-12 46.2 0.0 6.5e-12 45.3 0.0 1.4 1 1 0 1 1 1 1 BNR repeat-like domain BNR_3 PF13859.6 EGD98847.1 - 5.7e-10 39.0 0.0 8.1e-10 38.5 0.0 1.2 1 0 0 1 1 1 1 BNR repeat-like domain Rogdi_lz PF10259.9 EGD98848.1 - 1.9e-84 283.3 0.0 2.2e-84 283.1 0.0 1.0 1 0 0 1 1 1 1 Rogdi leucine zipper containing protein HSP70 PF00012.20 EGD98849.1 - 2.8e-83 280.1 1.0 2.8e-83 280.1 1.0 2.0 1 1 0 2 2 2 1 Hsp70 protein MreB_Mbl PF06723.13 EGD98849.1 - 3.7e-11 42.4 0.7 5.5e-11 41.9 0.7 1.2 1 0 0 1 1 1 1 MreB/Mbl protein PilM_2 PF11104.8 EGD98849.1 - 0.0028 16.7 0.1 2.2 7.2 0.0 2.7 2 1 1 3 3 3 2 Type IV pilus assembly protein PilM; PI3K_1B_p101 PF10486.9 EGD98849.1 - 0.11 10.2 0.4 0.18 9.6 0.4 1.2 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit CENP-B_dimeris PF09026.10 EGD98849.1 - 0.39 11.1 5.9 0.87 10.0 5.9 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain FAM176 PF14851.6 EGD98849.1 - 0.47 10.1 2.9 0.28 10.8 0.6 1.7 2 0 0 2 2 2 0 FAM176 family Radial_spoke PF04712.12 EGD98849.1 - 0.91 8.4 5.3 1.5 7.7 5.3 1.2 1 0 0 1 1 1 0 Radial spokehead-like protein DNA_pol_phi PF04931.13 EGD98849.1 - 7.6 4.5 6.5 11 3.9 6.5 1.2 1 0 0 1 1 1 0 DNA polymerase phi EamA PF00892.20 EGD98850.1 - 0.00076 19.7 34.1 0.0051 17.0 8.6 2.1 2 0 0 2 2 2 2 EamA-like transporter family SBP_bac_1 PF01547.25 EGD98850.1 - 0.072 13.0 0.1 12 5.7 0.1 2.2 2 0 0 2 2 2 0 Bacterial extracellular solute-binding protein DUF1077 PF06417.12 EGD98850.1 - 0.14 12.2 6.8 1.3 9.0 0.1 3.0 3 1 0 3 3 3 0 Protein of unknown function (DUF1077) Rpp20 PF12328.8 EGD98851.1 - 5.1e-44 149.6 9.4 9.9e-44 148.6 9.4 1.5 1 1 0 1 1 1 1 Rpp20 subunit of nuclear RNase MRP and P Alba PF01918.21 EGD98851.1 - 1.9e-14 53.2 0.3 3.5e-14 52.4 0.3 1.4 1 0 0 1 1 1 1 Alba 7TMR-HDED PF07697.11 EGD98851.1 - 0.0008 19.6 0.1 0.001 19.2 0.1 1.1 1 0 0 1 1 1 1 7TM-HD extracellular KH_6 PF15985.5 EGD98853.1 - 6.6e-16 58.4 0.1 1.2e-15 57.6 0.1 1.4 1 0 0 1 1 1 1 KH domain Rrp40_N PF18311.1 EGD98853.1 - 0.026 14.4 0.7 0.14 12.1 0.2 2.3 2 0 0 2 2 2 0 Exosome complex exonuclease Rrp40 N-terminal domain PhzC-PhzF PF02567.16 EGD98854.1 - 0.034 13.6 0.1 0.049 13.1 0.1 1.2 1 0 0 1 1 1 0 Phenazine biosynthesis-like protein FAM199X PF15814.5 EGD98856.1 - 8.8 5.3 11.6 0.43 9.6 1.3 2.1 2 0 0 2 2 2 0 Protein family FAM199X Glyco_transf_24 PF18404.1 EGD98857.1 - 3.7e-149 495.4 0.9 5.6e-149 494.9 0.9 1.3 1 0 0 1 1 1 1 Glucosyltransferase 24 Thioredoxin_14 PF18402.1 EGD98857.1 - 1.9e-63 214.8 0.0 4.6e-62 210.3 0.0 2.7 3 0 0 3 3 3 1 Thioredoxin-like domain Thioredoxin_12 PF18400.1 EGD98857.1 - 1.4e-47 162.0 1.5 1.9e-47 161.6 0.2 1.9 2 0 0 2 2 2 1 Thioredoxin-like domain Thioredoxin_15 PF18403.1 EGD98857.1 - 3.5e-44 151.3 0.1 8.4e-43 146.8 0.0 2.8 3 0 0 3 3 3 1 Thioredoxin-like domain Thioredoxin_13 PF18401.1 EGD98857.1 - 7e-43 145.8 1.3 1.2e-42 145.0 0.3 2.0 2 0 0 2 2 2 1 Thioredoxin-like domain UDP-g_GGTase PF06427.11 EGD98857.1 - 2.4e-41 140.2 0.0 4.7e-41 139.3 0.0 1.5 1 0 0 1 1 1 1 UDP-glucose:Glycoprotein Glucosyltransferase Glyco_transf_8 PF01501.20 EGD98857.1 - 0.00092 18.8 0.0 0.0017 18.0 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 8 Amidohydro_1 PF01979.20 EGD98858.1 - 3.8e-24 85.6 0.0 2.4e-23 83.0 0.0 2.0 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 EGD98858.1 - 3.6e-11 43.2 0.0 1e-05 25.2 0.0 2.4 3 0 0 3 3 3 2 Amidohydrolase family Arylsulfotran_N PF17425.2 EGD98858.1 - 0.059 13.4 0.0 0.12 12.4 0.0 1.4 1 0 0 1 1 1 0 Arylsulfotransferase Ig-like domain Glyco_hydro_26 PF02156.15 EGD98858.1 - 0.11 11.9 0.0 0.23 10.9 0.0 1.4 1 0 0 1 1 1 0 Glycosyl hydrolase family 26 Vma12 PF11712.8 EGD98859.1 - 5.8e-42 143.1 0.0 8.5e-42 142.5 0.0 1.2 1 0 0 1 1 1 1 Endoplasmic reticulum-based factor for assembly of V-ATPase HPP PF04982.13 EGD98859.1 - 0.063 13.5 0.0 0.11 12.7 0.0 1.3 1 0 0 1 1 1 0 HPP family Prefoldin PF02996.17 EGD98860.1 - 2.9e-31 107.9 0.1 4.1e-31 107.4 0.1 1.2 1 0 0 1 1 1 1 Prefoldin subunit Prefoldin_2 PF01920.20 EGD98860.1 - 0.0027 17.6 0.7 0.018 15.0 0.1 2.2 2 0 0 2 2 2 1 Prefoldin subunit End3 PF12761.7 EGD98860.1 - 0.013 15.7 0.4 0.069 13.3 0.1 2.0 2 0 0 2 2 2 0 Actin cytoskeleton-regulatory complex protein END3 FlaC_arch PF05377.11 EGD98860.1 - 0.027 14.9 0.5 0.73 10.3 0.2 2.5 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) Halogen_Hydrol PF10112.9 EGD98860.1 - 0.034 14.2 0.1 2.3 8.2 0.0 2.1 2 0 0 2 2 2 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein DMPK_coil PF08826.10 EGD98860.1 - 0.047 13.8 3.2 0.83 9.8 0.7 2.3 2 0 0 2 2 2 0 DMPK coiled coil domain like MetRS-N PF09635.10 EGD98860.1 - 0.098 13.2 0.1 0.19 12.3 0.1 1.4 1 0 0 1 1 1 0 MetRS-N binding domain Glyco_transf_28 PF03033.20 EGD98861.1 - 4.9e-30 104.4 0.0 2.8e-29 101.9 0.0 2.0 2 0 0 2 2 2 1 Glycosyltransferase family 28 N-terminal domain UDPGT PF00201.18 EGD98861.1 - 0.0048 15.7 0.0 0.0074 15.1 0.0 1.3 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Prenylcys_lyase PF07156.14 EGD98862.1 - 8.6e-93 311.3 0.0 1.1e-92 310.9 0.0 1.0 1 0 0 1 1 1 1 Prenylcysteine lyase Amino_oxidase PF01593.24 EGD98862.1 - 9.3e-13 48.3 0.0 1.4e-12 47.7 0.0 1.2 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EGD98862.1 - 2e-11 43.9 0.0 5e-11 42.7 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EGD98862.1 - 5.6e-08 32.8 0.1 0.00039 20.1 0.3 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EGD98862.1 - 0.0012 18.2 0.0 0.022 14.0 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EGD98862.1 - 0.0055 16.0 0.2 0.18 11.0 0.0 2.2 2 0 0 2 2 2 1 Thi4 family NAD_binding_9 PF13454.6 EGD98862.1 - 0.011 15.8 0.1 0.39 10.7 0.0 2.3 2 0 0 2 2 2 0 FAD-NAD(P)-binding Herpes_DNAp_acc PF04929.12 EGD98863.1 - 0.56 9.1 6.7 0.86 8.5 3.6 1.9 1 1 0 2 2 2 0 Herpes DNA replication accessory factor Glyco_hydro_18 PF00704.28 EGD98864.1 - 1.2e-65 222.3 0.0 1.8e-65 221.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 LysM PF01476.20 EGD98865.1 - 0.014 15.5 0.0 2.6 8.2 0.0 3.6 4 0 0 4 4 4 0 LysM domain CENP-B_dimeris PF09026.10 EGD98866.1 - 0.13 12.6 7.5 0.34 11.3 7.5 1.6 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DUF2457 PF10446.9 EGD98866.1 - 0.27 10.3 8.9 0.39 9.8 8.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) FAM176 PF14851.6 EGD98866.1 - 0.42 10.3 4.6 0.77 9.4 4.6 1.4 1 0 0 1 1 1 0 FAM176 family DNA_pol_phi PF04931.13 EGD98866.1 - 1.6 6.7 11.3 2.4 6.2 11.3 1.2 1 0 0 1 1 1 0 DNA polymerase phi Nop14 PF04147.12 EGD98866.1 - 3.9 5.6 8.4 5.1 5.2 8.4 1.1 1 0 0 1 1 1 0 Nop14-like family PDCD2_C PF04194.13 EGD98867.1 - 1.4e-43 149.0 0.6 7.1e-43 146.7 0.0 2.3 2 1 1 3 3 3 1 Programmed cell death protein 2, C-terminal putative domain CSN8_PSD8_EIF3K PF10075.9 EGD98868.1 - 3.6e-45 153.5 0.0 4.9e-45 153.0 0.0 1.2 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family Folliculin PF11704.8 EGD98869.1 - 3.2e-50 170.6 0.1 1.1e-49 168.9 0.0 1.9 2 0 0 2 2 2 1 Vesicle coat protein involved in Golgi to plasma membrane transport CLP1_P PF16575.5 EGD98870.1 - 1.4e-28 100.0 0.0 4.5e-28 98.3 0.0 1.8 1 1 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop DUF3095 PF11294.8 EGD98870.1 - 0.017 14.2 0.0 0.028 13.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3095) AAA_33 PF13671.6 EGD98870.1 - 0.034 14.3 0.4 0.27 11.4 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 EGD98870.1 - 0.067 13.5 0.0 0.18 12.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain RNA_polI_A34 PF08208.11 EGD98871.1 - 4.1e-25 89.1 0.0 4.1e-25 89.1 0.0 2.3 2 1 0 2 2 2 1 DNA-directed RNA polymerase I subunit RPA34.5 TFIIF_alpha PF05793.12 EGD98871.1 - 0.065 11.8 11.6 0.087 11.4 11.6 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) BSP_II PF05432.11 EGD98871.1 - 0.14 11.8 11.4 0.2 11.3 11.4 1.2 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) DUF3824 PF12868.7 EGD98871.1 - 0.2 12.3 8.9 0.34 11.6 8.9 1.3 1 0 0 1 1 1 0 Domain of unknwon function (DUF3824) CDC45 PF02724.14 EGD98871.1 - 0.78 8.0 6.3 0.89 7.8 6.3 1.1 1 0 0 1 1 1 0 CDC45-like protein Apt1 PF10351.9 EGD98871.1 - 1.3 7.8 7.7 1.5 7.6 7.7 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Nop14 PF04147.12 EGD98871.1 - 1.5 7.0 9.4 1.8 6.7 9.4 1.1 1 0 0 1 1 1 0 Nop14-like family DUF4614 PF15391.6 EGD98871.1 - 2.6 8.0 14.2 5.2 7.0 14.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) SHMT PF00464.19 EGD98872.1 - 1.1e-206 686.1 0.0 1.3e-206 685.9 0.0 1.0 1 0 0 1 1 1 1 Serine hydroxymethyltransferase Aminotran_1_2 PF00155.21 EGD98872.1 - 6.9e-06 25.5 0.0 2.4e-05 23.7 0.0 1.8 1 1 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 EGD98872.1 - 0.00084 18.4 0.0 0.0013 17.7 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 EGD98872.1 - 0.13 10.8 0.0 0.24 9.9 0.0 1.4 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme DUF3040 PF11239.8 EGD98872.1 - 0.16 12.3 0.1 0.32 11.3 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3040) Med9 PF07544.13 EGD98873.1 - 4.8e-15 55.4 0.1 8.4e-15 54.6 0.1 1.6 1 1 0 1 1 1 1 RNA polymerase II transcription mediator complex subunit 9 Med21 PF11221.8 EGD98873.1 - 0.087 13.1 3.6 0.76 10.0 0.1 2.1 2 0 0 2 2 2 0 Subunit 21 of Mediator complex Spc42p PF11544.8 EGD98873.1 - 0.18 11.8 0.1 0.34 11.0 0.1 1.4 1 0 0 1 1 1 0 Spindle pole body component Spc42p iPGM_N PF06415.13 EGD98874.1 - 2e-78 262.7 0.0 2.8e-78 262.3 0.0 1.2 1 0 0 1 1 1 1 BPG-independent PGAM N-terminus (iPGM_N) Metalloenzyme PF01676.18 EGD98874.1 - 1.1e-70 237.9 0.0 1.3e-70 237.7 0.0 1.0 1 0 0 1 1 1 1 Metalloenzyme superfamily Sulfatase PF00884.23 EGD98874.1 - 0.00037 20.0 0.0 0.018 14.4 0.0 2.5 2 1 1 3 3 3 1 Sulfatase Alk_phosphatase PF00245.20 EGD98874.1 - 0.015 14.3 0.1 0.061 12.3 0.0 1.8 2 0 0 2 2 2 0 Alkaline phosphatase Prefoldin_2 PF01920.20 EGD98875.1 - 6.2e-22 77.6 19.4 8.3e-22 77.2 19.4 1.2 1 0 0 1 1 1 1 Prefoldin subunit Prefoldin_3 PF13758.6 EGD98875.1 - 3.9e-06 26.8 7.2 5.7e-06 26.3 7.2 1.2 1 0 0 1 1 1 1 Prefoldin subunit Prefoldin PF02996.17 EGD98875.1 - 0.00089 19.2 1.2 0.00089 19.2 1.2 2.5 2 1 0 2 2 2 1 Prefoldin subunit Spc24 PF08286.11 EGD98875.1 - 0.0046 17.2 17.1 0.031 14.5 6.9 2.1 1 1 1 2 2 2 1 Spc24 subunit of Ndc80 Taxilin PF09728.9 EGD98875.1 - 0.0086 15.3 14.2 0.031 13.5 6.5 2.1 2 0 0 2 2 2 1 Myosin-like coiled-coil protein ABC_tran_CTD PF16326.5 EGD98875.1 - 0.012 15.9 20.1 0.24 11.7 3.0 3.1 2 1 1 3 3 3 0 ABC transporter C-terminal domain YabA PF06156.13 EGD98875.1 - 0.013 16.1 9.6 0.31 11.7 0.4 2.1 2 0 0 2 2 2 0 Initiation control protein YabA CCDC144C PF14915.6 EGD98875.1 - 0.013 14.6 13.5 0.16 11.0 3.2 2.1 2 0 0 2 2 2 0 CCDC144C protein coiled-coil region TMF_TATA_bd PF12325.8 EGD98875.1 - 0.013 15.7 13.5 0.38 11.0 5.7 2.1 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding SlyX PF04102.12 EGD98875.1 - 0.016 15.8 0.6 0.016 15.8 0.6 2.9 2 1 0 2 2 2 0 SlyX Siah-Interact_N PF09032.11 EGD98875.1 - 0.017 15.4 11.0 0.69 10.3 3.8 2.3 2 0 0 2 2 2 0 Siah interacting protein, N terminal CENP-H PF05837.12 EGD98875.1 - 0.018 15.5 8.5 0.46 10.9 0.2 2.2 2 0 0 2 2 2 0 Centromere protein H (CENP-H) Osmo_CC PF08946.10 EGD98875.1 - 0.032 14.5 5.0 0.032 14.5 5.0 2.4 2 0 0 2 2 2 0 Osmosensory transporter coiled coil SOGA PF11365.8 EGD98875.1 - 0.033 15.3 5.0 2 9.6 0.1 2.1 2 0 0 2 2 2 0 Protein SOGA XhlA PF10779.9 EGD98875.1 - 0.04 14.1 2.4 0.04 14.1 2.4 2.2 2 1 0 2 2 2 0 Haemolysin XhlA TolA_bind_tri PF16331.5 EGD98875.1 - 0.042 13.9 16.0 0.79 9.8 6.3 2.4 2 0 0 2 2 2 0 TolA binding protein trimerisation HDV_ag PF01517.18 EGD98875.1 - 0.042 13.6 1.7 0.12 12.2 1.8 1.7 1 1 0 1 1 1 0 Hepatitis delta virus delta antigen EzrA PF06160.12 EGD98875.1 - 0.057 11.6 15.6 0.025 12.8 3.6 2.0 2 0 0 2 2 2 0 Septation ring formation regulator, EzrA DegS PF05384.11 EGD98875.1 - 0.09 12.3 10.8 0.5 9.8 2.8 2.2 2 0 0 2 2 2 0 Sensor protein DegS Spc7 PF08317.11 EGD98875.1 - 0.092 11.6 18.4 0.14 11.0 18.4 1.2 1 1 0 1 1 1 0 Spc7 kinetochore protein Swi5 PF07061.11 EGD98875.1 - 0.092 12.8 11.0 1.6 8.9 5.3 2.5 2 0 0 2 2 2 0 Swi5 PHM7_cyt PF14703.6 EGD98875.1 - 0.1 12.8 9.1 0.19 12.0 9.1 1.5 1 1 0 1 1 1 0 Cytosolic domain of 10TM putative phosphate transporter NPV_P10 PF05531.12 EGD98875.1 - 0.1 13.1 11.8 1.6 9.3 3.5 2.2 1 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Tropomyosin_1 PF12718.7 EGD98875.1 - 0.11 12.6 17.0 0.4 10.8 7.3 2.1 2 0 0 2 2 2 0 Tropomyosin like Uso1_p115_C PF04871.13 EGD98875.1 - 0.12 12.8 17.4 0.18 12.2 8.1 2.2 2 0 0 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region End3 PF12761.7 EGD98875.1 - 0.12 12.5 11.7 0.17 12.0 11.7 1.2 1 0 0 1 1 1 0 Actin cytoskeleton-regulatory complex protein END3 TPR_MLP1_2 PF07926.12 EGD98875.1 - 0.14 12.3 17.2 0.19 11.8 8.3 2.2 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein Tropomyosin PF00261.20 EGD98875.1 - 0.15 11.4 15.5 0.16 11.3 2.1 2.0 2 0 0 2 2 2 0 Tropomyosin GAS PF13851.6 EGD98875.1 - 0.15 11.4 17.1 0.17 11.2 6.9 2.1 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding APG6_N PF17675.1 EGD98875.1 - 0.21 12.1 24.0 0.88 10.1 4.7 2.1 1 1 1 2 2 2 0 Apg6 coiled-coil region COG5 PF10392.9 EGD98875.1 - 0.22 11.7 5.9 2.9 8.1 1.1 2.1 1 1 0 2 2 2 0 Golgi transport complex subunit 5 DUF4407 PF14362.6 EGD98875.1 - 0.28 10.5 13.1 0.55 9.5 13.1 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) WEMBL PF05701.11 EGD98875.1 - 0.31 9.7 16.2 0.074 11.7 2.2 2.0 1 1 1 2 2 2 0 Weak chloroplast movement under blue light Atg14 PF10186.9 EGD98875.1 - 0.35 9.9 9.5 0.51 9.4 9.5 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 betaPIX_CC PF16523.5 EGD98875.1 - 0.38 10.6 10.7 0.23 11.3 3.8 2.3 2 1 0 2 2 2 0 betaPIX coiled coil DUF5082 PF16888.5 EGD98875.1 - 0.41 10.9 17.3 1.7 8.9 17.3 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF5082) DUF1664 PF07889.12 EGD98875.1 - 0.46 10.5 13.3 2.4 8.2 3.2 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Rx_N PF18052.1 EGD98875.1 - 0.55 10.5 12.6 0.44 10.9 3.7 2.4 2 1 0 2 2 2 0 Rx N-terminal domain FlaC_arch PF05377.11 EGD98875.1 - 0.56 10.6 11.5 1.7 9.1 0.8 3.3 2 2 1 3 3 3 0 Flagella accessory protein C (FlaC) MtrG PF04210.13 EGD98875.1 - 0.56 10.1 5.5 0.43 10.5 1.3 2.5 2 1 0 2 2 2 0 Tetrahydromethanopterin S-methyltransferase, subunit G ERM PF00769.19 EGD98875.1 - 0.66 9.8 19.5 1.3 8.7 19.5 1.4 1 1 0 1 1 1 0 Ezrin/radixin/moesin family DivIC PF04977.15 EGD98875.1 - 0.72 9.7 23.7 0.64 9.8 3.7 3.2 2 1 1 3 3 3 0 Septum formation initiator MIP-T3_C PF17749.1 EGD98875.1 - 0.76 9.7 14.5 0.099 12.6 5.3 2.1 2 0 0 2 2 2 0 Microtubule-binding protein MIP-T3 C-terminal region DHR10 PF18595.1 EGD98875.1 - 0.77 9.8 21.1 0.76 9.8 8.3 2.2 2 0 0 2 2 2 0 Designed helical repeat protein 10 domain Laminin_II PF06009.12 EGD98875.1 - 1 9.4 12.5 1.6 8.8 1.2 2.1 1 1 0 2 2 2 0 Laminin Domain II Occludin_ELL PF07303.13 EGD98875.1 - 1 10.1 8.9 1.7 9.4 5.1 2.2 1 1 1 2 2 2 0 Occludin homology domain CENP-F_leu_zip PF10473.9 EGD98875.1 - 1 9.4 16.0 2.8 7.9 3.3 2.1 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF4349 PF14257.6 EGD98875.1 - 1.3 8.4 17.9 0.18 11.3 0.9 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4349) BRE1 PF08647.11 EGD98875.1 - 1.5 9.0 18.0 0.35 11.0 2.2 2.5 2 1 0 2 2 2 0 BRE1 E3 ubiquitin ligase Snapin_Pallidin PF14712.6 EGD98875.1 - 1.6 9.2 13.1 0.44 11.0 1.0 2.3 2 0 0 2 2 2 0 Snapin/Pallidin CorA PF01544.18 EGD98875.1 - 1.7 7.9 7.9 0.38 10.0 0.9 2.0 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein DUF4164 PF13747.6 EGD98875.1 - 1.7 9.0 12.3 1.8 8.9 5.9 2.4 1 1 0 2 2 2 0 Domain of unknown function (DUF4164) DUF4200 PF13863.6 EGD98875.1 - 1.7 9.0 19.1 4.1 7.8 4.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) DUF724 PF05266.14 EGD98875.1 - 1.8 8.4 12.3 0.61 9.9 1.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF724) GrpE PF01025.19 EGD98875.1 - 2.4 7.8 14.4 3.9 7.1 5.8 2.1 2 0 0 2 2 2 0 GrpE Rootletin PF15035.6 EGD98875.1 - 2.4 8.1 13.4 0.51 10.3 6.5 2.0 2 0 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion ACCA PF03255.14 EGD98875.1 - 2.8 7.8 9.7 3.8 7.4 0.9 2.2 2 0 0 2 2 2 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit Sec34 PF04136.15 EGD98875.1 - 2.9 7.8 10.7 4 7.3 3.1 2.1 2 0 0 2 2 2 0 Sec34-like family CENP-Q PF13094.6 EGD98875.1 - 3.1 8.0 14.8 5.6 7.1 14.8 1.4 1 1 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit Jnk-SapK_ap_N PF09744.9 EGD98875.1 - 3.2 8.0 16.9 8.1 6.6 16.9 1.6 1 1 0 1 1 1 0 JNK_SAPK-associated protein-1 Fez1 PF06818.15 EGD98875.1 - 3.7 7.9 17.2 1.5 9.3 3.2 2.1 1 1 0 2 2 2 0 Fez1 HMMR_N PF15905.5 EGD98875.1 - 3.8 6.9 18.2 27 4.1 18.2 1.9 1 1 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal Flagellin_N PF00669.20 EGD98875.1 - 3.8 7.6 11.3 0.69 10.0 4.1 2.1 2 0 0 2 2 2 0 Bacterial flagellin N-terminal helical region OmpH PF03938.14 EGD98875.1 - 3.9 7.8 26.6 4.6e+02 1.1 26.9 2.1 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) AAA_13 PF13166.6 EGD98875.1 - 4.1 5.9 16.6 0.083 11.5 2.7 2.0 1 1 1 2 2 2 0 AAA domain DUF641 PF04859.12 EGD98875.1 - 4.2 7.7 13.3 3.3 8.1 3.7 2.2 1 1 0 2 2 2 0 Plant protein of unknown function (DUF641) Chibby PF14645.6 EGD98875.1 - 4.2 7.8 8.1 6.9 7.1 3.5 2.7 1 1 1 2 2 2 0 Chibby family Fib_alpha PF08702.10 EGD98875.1 - 4.4 7.5 15.4 1.5e+02 2.5 15.4 2.1 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family RPW8 PF05659.11 EGD98875.1 - 4.5 7.0 9.2 1.2 8.9 1.7 2.1 1 1 1 2 2 2 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 THOC7 PF05615.13 EGD98875.1 - 4.7 7.5 18.4 0.31 11.3 5.0 2.1 1 1 1 2 2 2 0 Tho complex subunit 7 Sas10_Utp3 PF04000.15 EGD98875.1 - 5.9 7.6 7.4 38 5.0 0.1 2.4 2 1 0 2 2 2 0 Sas10/Utp3/C1D family FapA PF03961.13 EGD98875.1 - 6.2 5.3 14.1 31 3.0 14.1 1.8 1 1 0 1 1 1 0 Flagellar Assembly Protein A DUF2408 PF10303.9 EGD98875.1 - 7.2 7.2 11.0 29 5.2 11.0 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF2408) Allexi_40kDa PF05549.11 EGD98875.1 - 7.4 6.0 6.1 13 5.2 1.2 1.9 1 1 1 2 2 2 0 Allexivirus 40kDa protein Peptidase_S49_N PF08496.10 EGD98875.1 - 7.7 6.6 11.2 13 5.8 10.9 1.5 1 1 0 1 1 1 0 Peptidase family S49 N-terminal PspA_IM30 PF04012.12 EGD98875.1 - 7.8 6.0 18.7 46 3.5 18.7 1.8 1 1 0 1 1 1 0 PspA/IM30 family UPF0242 PF06785.11 EGD98875.1 - 8 6.5 22.8 1.7 8.7 9.3 2.0 1 1 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus TMPIT PF07851.13 EGD98875.1 - 8.5 5.5 12.1 25 4.0 12.1 1.7 1 1 0 1 1 1 0 TMPIT-like protein COG2 PF06148.11 EGD98875.1 - 8.7 6.4 11.3 14 5.8 0.9 2.1 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 AAA PF00004.29 EGD98876.1 - 6.6e-43 146.3 0.0 1.1e-42 145.6 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.10 EGD98876.1 - 2.3e-27 94.8 0.1 7.3e-27 93.1 0.1 2.0 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain MIT PF04212.18 EGD98876.1 - 9.3e-24 83.3 1.8 2e-23 82.2 1.8 1.6 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain AAA_lid_3 PF17862.1 EGD98876.1 - 1e-05 25.2 0.0 2.9e-05 23.8 0.0 1.7 1 0 0 1 1 1 1 AAA+ lid domain RuvB_N PF05496.12 EGD98876.1 - 1.2e-05 25.1 0.0 2.7e-05 24.0 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EGD98876.1 - 2.4e-05 24.8 0.0 0.00013 22.4 0.0 2.1 1 1 0 1 1 1 1 AAA ATPase domain AAA_2 PF07724.14 EGD98876.1 - 4.3e-05 23.7 0.0 0.00046 20.4 0.0 2.2 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) IstB_IS21 PF01695.17 EGD98876.1 - 9.8e-05 22.1 0.0 0.0002 21.2 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_5 PF07728.14 EGD98876.1 - 9.9e-05 22.4 0.0 0.00047 20.2 0.0 2.1 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) TIP49 PF06068.13 EGD98876.1 - 0.00018 20.9 0.0 0.00026 20.3 0.0 1.2 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_14 PF13173.6 EGD98876.1 - 0.00018 21.5 0.0 0.00047 20.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EGD98876.1 - 0.00027 21.2 0.1 0.022 15.0 0.0 2.5 1 1 1 2 2 2 1 AAA domain AAA_18 PF13238.6 EGD98876.1 - 0.00043 20.8 0.0 0.003 18.1 0.0 2.3 2 0 0 2 2 2 1 AAA domain DUF815 PF05673.13 EGD98876.1 - 0.00081 18.6 0.0 0.0065 15.7 0.0 2.0 1 1 1 2 2 2 1 Protein of unknown function (DUF815) AAA_33 PF13671.6 EGD98876.1 - 0.0014 18.8 0.0 0.0029 17.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 EGD98876.1 - 0.0033 17.8 0.0 0.012 16.0 0.0 2.0 2 0 0 2 2 1 1 RNA helicase AAA_24 PF13479.6 EGD98876.1 - 0.0044 16.8 0.0 0.012 15.4 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.6 EGD98876.1 - 0.011 16.2 0.0 0.051 14.0 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 EGD98876.1 - 0.016 14.8 0.2 0.72 9.4 0.1 2.7 2 1 1 3 3 3 0 AAA domain AAA_7 PF12775.7 EGD98876.1 - 0.019 14.5 0.0 0.098 12.2 0.0 2.1 2 1 0 2 2 2 0 P-loop containing dynein motor region ATPase PF06745.13 EGD98876.1 - 0.023 14.0 0.0 8.9 5.6 0.0 2.9 2 1 0 3 3 3 0 KaiC NACHT PF05729.12 EGD98876.1 - 0.037 14.0 0.0 0.37 10.7 0.0 2.1 1 1 1 2 2 2 0 NACHT domain Mg_chelatase PF01078.21 EGD98876.1 - 0.039 13.3 0.0 0.081 12.3 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Parvo_NS1 PF01057.17 EGD98876.1 - 0.071 12.2 0.0 0.13 11.3 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 PhoH PF02562.16 EGD98876.1 - 0.072 12.5 0.1 0.17 11.3 0.1 1.5 1 0 0 1 1 1 0 PhoH-like protein ATPase_2 PF01637.18 EGD98876.1 - 0.087 12.7 0.0 0.73 9.7 0.0 2.2 1 1 0 2 2 2 0 ATPase domain predominantly from Archaea USP8_dimer PF08969.11 EGD98876.1 - 0.093 12.9 0.6 0.18 12.0 0.6 1.5 1 0 0 1 1 1 0 USP8 dimerisation domain Torsin PF06309.11 EGD98876.1 - 0.1 12.7 0.0 0.19 11.8 0.0 1.4 1 0 0 1 1 1 0 Torsin Sigma54_activat PF00158.26 EGD98876.1 - 0.14 11.9 0.0 0.5 10.1 0.0 1.9 1 1 1 2 2 2 0 Sigma-54 interaction domain ParB PF08775.10 EGD98876.1 - 0.14 12.6 0.0 0.34 11.4 0.0 1.6 1 0 0 1 1 1 0 ParB family TPR_1 PF00515.28 EGD98876.1 - 0.17 11.8 0.6 0.6 10.0 0.6 2.0 1 0 0 1 1 1 0 Tetratricopeptide repeat Cnn_1N PF07989.11 EGD98877.1 - 6.8e-23 80.6 6.4 6.8e-23 80.6 6.4 15.4 8 3 4 13 13 13 2 Centrosomin N-terminal motif 1 PACT_coil_coil PF10495.9 EGD98877.1 - 1.2e-11 45.0 2.5 1.2e-11 45.0 2.5 5.9 5 1 0 5 5 5 1 Pericentrin-AKAP-450 domain of centrosomal targeting protein TMF_DNA_bd PF12329.8 EGD98877.1 - 3.4e-08 33.4 14.6 3.4e-08 33.4 14.6 16.1 9 6 9 18 18 18 3 TATA element modulatory factor 1 DNA binding CENP-F_leu_zip PF10473.9 EGD98877.1 - 0.0096 15.9 14.9 0.0096 15.9 14.9 10.8 2 2 7 10 10 10 3 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 SGT1 PF07093.11 EGD98878.1 - 3.5e-63 214.0 11.3 1.4e-47 162.5 0.0 3.1 1 1 2 3 3 3 3 SGT1 protein AMMECR1 PF01871.17 EGD98880.1 - 9.4e-40 135.9 0.0 1.6e-39 135.2 0.0 1.3 1 0 0 1 1 1 1 AMMECR1 DUF4880 PF16220.5 EGD98880.1 - 0.026 14.4 0.2 0.065 13.1 0.2 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4880) Hamartin PF04388.12 EGD98880.1 - 9.3 4.8 7.8 12 4.5 7.8 1.1 1 0 0 1 1 1 0 Hamartin protein Pkinase PF00069.25 EGD98882.1 - 5.1e-71 239.1 0.0 6.4e-71 238.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD98882.1 - 3.3e-28 98.7 0.0 4.3e-28 98.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EGD98882.1 - 2.4e-07 30.4 0.0 3.8e-07 29.7 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EGD98882.1 - 0.00014 20.8 0.0 0.00023 20.1 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EGD98882.1 - 0.00056 19.9 0.1 0.00079 19.4 0.1 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 EGD98882.1 - 0.00062 19.2 0.1 0.001 18.5 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family DUF1744 PF08490.12 EGD98883.1 - 3.7e-150 500.0 0.9 5.5e-150 499.4 0.9 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1744) DNA_pol_B_exo1 PF03104.19 EGD98883.1 - 1e-81 274.8 1.5 1.5e-81 274.2 0.3 2.0 2 0 0 2 2 2 1 DNA polymerase family B, exonuclease domain DNA_pol_B PF00136.21 EGD98883.1 - 2.1e-16 59.7 1.1 9.3e-13 47.7 0.0 4.4 4 1 0 4 4 4 2 DNA polymerase family B DNA_pol_B_exo2 PF10108.9 EGD98883.1 - 9.3e-10 38.5 0.1 3.1e-09 36.8 0.1 1.9 1 0 0 1 1 1 1 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB RNase_H_2 PF13482.6 EGD98883.1 - 2e-05 24.6 0.1 9.5e-05 22.4 0.0 2.3 2 0 0 2 2 2 1 RNase_H superfamily DUF3767 PF12597.8 EGD98884.1 - 2e-32 111.0 0.2 4.2e-32 110.0 0.0 1.5 1 1 1 2 2 2 2 Protein of unknown function (DUF3767) Nop PF01798.18 EGD98886.1 - 5.8e-87 291.0 0.0 5.8e-87 291.0 0.0 1.8 2 0 0 2 2 2 1 snoRNA binding domain, fibrillarin NOP5NT PF08156.13 EGD98886.1 - 4e-18 65.6 0.1 4e-18 65.6 0.1 2.5 3 0 0 3 3 3 1 NOP5NT (NUC127) domain RP-C_C PF11800.8 EGD98886.1 - 0.057 13.5 9.8 0.45 10.6 0.0 2.3 2 0 0 2 2 2 0 Replication protein C C-terminal region RNA_polI_A34 PF08208.11 EGD98886.1 - 0.12 12.5 33.5 0.2 11.7 33.5 1.4 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 YL1 PF05764.13 EGD98886.1 - 0.35 10.9 27.3 0.53 10.4 27.3 1.3 1 0 0 1 1 1 0 YL1 nuclear protein CobT PF06213.12 EGD98886.1 - 6.3 6.1 22.7 6 6.2 21.1 1.7 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT Cpn60_TCP1 PF00118.24 EGD98887.1 - 2.4e-161 537.7 1.2 2.7e-161 537.5 1.2 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family MOZ_SAS PF01853.18 EGD98888.1 - 4.8e-64 215.3 0.0 6.4e-64 214.9 0.0 1.1 1 0 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 EGD98888.1 - 8e-15 54.2 0.2 1.4e-14 53.4 0.2 1.4 1 0 0 1 1 1 1 MYST family zinc finger domain RRM_1 PF00076.22 EGD98889.1 - 6.3e-14 51.6 0.0 1.2e-13 50.7 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) AA_permease_2 PF13520.6 EGD98890.1 - 2.4e-56 191.4 45.0 2.8e-56 191.1 45.0 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EGD98890.1 - 5.3e-19 68.2 36.0 7.2e-19 67.7 36.0 1.1 1 0 0 1 1 1 1 Amino acid permease Sec23_trunk PF04811.15 EGD98891.1 - 2.2e-44 151.8 0.0 3.5e-44 151.2 0.0 1.2 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.15 EGD98891.1 - 1.2e-17 63.6 0.0 3e-17 62.3 0.0 1.6 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Sec23_BS PF08033.12 EGD98891.1 - 1.6e-17 64.0 0.0 4.5e-17 62.6 0.0 1.8 2 0 0 2 2 2 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.15 EGD98891.1 - 8.7e-16 57.7 5.5 1.7e-15 56.7 5.5 1.5 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 EGD98891.1 - 2.4e-06 27.3 0.0 5.9e-06 26.1 0.0 1.6 1 0 0 1 1 1 1 Gelsolin repeat Fe-ADH PF00465.19 EGD98891.1 - 0.21 10.4 0.1 0.51 9.1 0.1 1.6 2 0 0 2 2 2 0 Iron-containing alcohol dehydrogenase Bys1 PF04681.12 EGD98892.1 - 2.4e-06 27.6 0.2 3e-06 27.3 0.2 1.2 1 0 0 1 1 1 1 Blastomyces yeast-phase-specific protein Thaumatin PF00314.17 EGD98892.1 - 0.0036 17.0 0.4 0.0086 15.7 0.2 1.6 1 1 0 1 1 1 1 Thaumatin family ABC_tran PF00005.27 EGD98893.1 - 1.8e-49 167.8 0.1 7.9e-25 88.0 0.0 2.3 2 0 0 2 2 2 2 ABC transporter ABC2_membrane PF01061.24 EGD98893.1 - 8.1e-48 162.6 33.5 2.2e-25 89.4 13.7 2.4 2 0 0 2 2 2 2 ABC-2 type transporter AAA_21 PF13304.6 EGD98893.1 - 4.2e-11 43.2 6.8 0.0025 17.7 0.1 4.6 4 0 0 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 EGD98893.1 - 8.2e-09 36.3 1.3 0.00021 21.9 0.0 2.3 2 0 0 2 2 2 2 AAA domain SMC_N PF02463.19 EGD98893.1 - 8.9e-09 35.1 0.7 0.0075 15.7 0.1 3.9 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 EGD98893.1 - 1.7e-07 31.3 1.9 0.018 15.0 1.0 2.5 2 0 0 2 2 2 2 RsgA GTPase AAA_16 PF13191.6 EGD98893.1 - 2.5e-07 31.2 0.1 0.013 15.9 0.0 2.4 2 0 0 2 2 2 2 AAA ATPase domain AAA_29 PF13555.6 EGD98893.1 - 3.3e-06 26.7 2.5 0.087 12.6 0.0 2.9 2 0 0 2 2 2 2 P-loop containing region of AAA domain NACHT PF05729.12 EGD98893.1 - 1.9e-05 24.7 0.4 0.051 13.5 0.1 2.4 2 0 0 2 2 2 2 NACHT domain ATPase_2 PF01637.18 EGD98893.1 - 8.9e-05 22.5 0.1 0.0033 17.4 0.0 2.3 2 0 0 2 2 2 1 ATPase domain predominantly from Archaea AAA_22 PF13401.6 EGD98893.1 - 0.00016 22.0 0.2 0.54 10.5 0.0 3.2 3 0 0 3 3 3 1 AAA domain AAA_30 PF13604.6 EGD98893.1 - 0.00017 21.3 0.3 0.21 11.3 0.1 2.3 2 0 0 2 2 2 2 AAA domain AAA PF00004.29 EGD98893.1 - 0.00031 21.2 0.7 1.2 9.6 0.1 2.8 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) AAA_15 PF13175.6 EGD98893.1 - 0.00033 20.5 0.3 2.5 7.7 0.2 3.2 3 0 0 3 3 3 1 AAA ATPase domain AAA_28 PF13521.6 EGD98893.1 - 0.00034 20.9 0.5 0.26 11.5 0.1 2.4 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 EGD98893.1 - 0.001 19.4 0.2 0.93 9.9 0.0 2.4 2 0 0 2 2 2 1 RNA helicase AAA_25 PF13481.6 EGD98893.1 - 0.0029 17.2 0.6 0.38 10.3 0.0 2.4 2 0 0 2 2 2 1 AAA domain cobW PF02492.19 EGD98893.1 - 0.0031 17.1 3.2 0.32 10.6 0.2 2.3 2 0 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain DnaB_C PF03796.15 EGD98893.1 - 0.0034 16.8 0.2 2.3 7.5 0.0 2.4 2 0 0 2 2 2 2 DnaB-like helicase C terminal domain AAA_19 PF13245.6 EGD98893.1 - 0.0066 16.8 0.5 1.1 9.5 0.1 2.4 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.14 EGD98893.1 - 0.011 15.8 0.2 6.7 6.7 0.0 3.7 4 0 0 4 4 4 0 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 EGD98893.1 - 0.016 15.8 0.1 3.2 8.3 0.0 2.5 2 0 0 2 2 2 0 AAA domain RuvB_N PF05496.12 EGD98893.1 - 0.017 14.8 0.2 2.7 7.7 0.1 2.5 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain T2SSE PF00437.20 EGD98893.1 - 0.018 14.1 0.1 2.4 7.2 0.0 2.2 2 0 0 2 2 2 0 Type II/IV secretion system protein Roc PF08477.13 EGD98893.1 - 0.037 14.2 0.9 5.6 7.2 0.2 2.5 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 EGD98893.1 - 0.082 13.0 3.8 0.59 10.2 0.7 2.4 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_17 PF13207.6 EGD98893.1 - 0.088 13.2 0.6 6.9 7.1 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 EGD98893.1 - 0.091 12.5 0.7 8 6.1 0.0 2.4 2 0 0 2 2 2 0 AAA domain Rad17 PF03215.15 EGD98893.1 - 0.095 12.6 0.0 6 6.7 0.0 2.4 2 0 0 2 2 2 0 Rad17 P-loop domain NTPase_1 PF03266.15 EGD98893.1 - 0.11 12.4 0.7 17 5.3 0.3 2.7 3 0 0 3 3 2 0 NTPase PRK PF00485.18 EGD98893.1 - 0.14 11.9 0.7 10 5.8 0.2 2.3 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family PDR_CDR PF06422.12 EGD98893.1 - 0.14 12.1 0.2 0.46 10.4 0.2 1.8 1 0 0 1 1 1 0 CDR ABC transporter Pox_A32 PF04665.12 EGD98893.1 - 0.18 11.3 2.4 7.6 5.9 0.5 2.3 2 0 0 2 2 2 0 Poxvirus A32 protein AAA_11 PF13086.6 EGD98893.1 - 0.21 11.4 0.1 1.9 8.2 0.0 2.1 2 0 0 2 2 2 0 AAA domain DUF2075 PF09848.9 EGD98893.1 - 0.21 10.8 0.4 13 4.9 0.1 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) IstB_IS21 PF01695.17 EGD98893.1 - 0.28 10.9 0.9 2.3 7.9 0.0 2.5 2 0 0 2 2 2 0 IstB-like ATP binding protein MobB PF03205.14 EGD98893.1 - 0.32 10.9 1.4 17 5.3 0.3 2.3 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B Zeta_toxin PF06414.12 EGD98893.1 - 0.36 10.1 1.1 13 5.0 0.4 2.3 2 0 0 2 2 2 0 Zeta toxin Fungal_trans_2 PF11951.8 EGD98894.1 - 6.8e-68 229.2 0.1 9.1e-68 228.8 0.1 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EGD98894.1 - 1.5e-09 37.8 10.0 2.7e-09 37.0 10.0 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain AT_hook PF02178.19 EGD98894.1 - 0.21 11.5 6.6 0.72 9.9 6.6 2.0 1 0 0 1 1 1 0 AT hook motif O_anti_polymase PF01901.16 EGD98895.1 - 0.23 10.7 0.7 0.34 10.1 0.7 1.1 1 0 0 1 1 1 0 Putative O-antigen polymerase DUF2434 PF10361.9 EGD98896.1 - 1.2e-120 401.9 6.4 1.5e-120 401.6 6.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2434) Baculo_IE-1 PF05290.11 EGD98896.1 - 0.12 12.3 0.0 0.23 11.4 0.0 1.4 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) DKCLD PF08068.12 EGD98896.1 - 0.24 11.5 0.6 0.5 10.5 0.0 1.8 2 0 0 2 2 2 0 DKCLD (NUC011) domain ORC6 PF05460.13 EGD98898.1 - 0.7 9.1 2.6 0.74 9.0 2.6 1.1 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) MAGI_u5 PF16666.5 EGD98898.1 - 1.2 9.3 14.1 0.076 13.2 9.0 1.7 1 1 1 2 2 2 0 Unstructured region on MAGI DUF2461 PF09365.10 EGD98902.1 - 4.7e-18 65.9 0.2 9e-18 65.0 0.2 1.4 1 0 0 1 1 1 1 Conserved hypothetical protein (DUF2461) DUF3984 PF13136.6 EGD98902.1 - 0.053 12.9 10.1 0.086 12.2 10.1 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3984) Sporozoite_P67 PF05642.11 EGD98902.1 - 0.36 8.9 6.9 0.49 8.4 6.9 1.3 1 0 0 1 1 1 0 Sporozoite P67 surface antigen TYW3 PF02676.14 EGD98903.1 - 3.7e-71 238.9 0.0 5.4e-71 238.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase TYW3 ARPC4 PF05856.12 EGD98905.1 - 1.1e-78 262.6 3.3 1.2e-78 262.5 3.3 1.0 1 0 0 1 1 1 1 ARP2/3 complex 20 kDa subunit (ARPC4) UCH PF00443.29 EGD98906.1 - 1.3e-48 165.8 5.7 2e-48 165.1 5.7 1.3 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EGD98906.1 - 8.2e-12 45.3 10.7 2.9e-11 43.5 10.7 1.9 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase ubiquitin PF00240.23 EGD98906.1 - 9e-11 41.4 0.0 2.1e-10 40.2 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin family RILP PF11461.8 EGD98906.1 - 0.63 10.3 0.0 0.63 10.3 0.0 3.2 3 1 0 3 3 3 0 Rab interacting lysosomal protein PTPRCAP PF15713.5 EGD98906.1 - 1.1 9.6 9.7 3 8.1 9.7 1.7 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated DUF2992 PF11208.8 EGD98906.1 - 3.6 7.8 14.3 6.9 6.9 14.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2992) 4HBT PF03061.22 EGD98907.1 - 5.3e-07 29.9 0.0 1.3e-06 28.7 0.0 1.7 1 0 0 1 1 1 1 Thioesterase superfamily DUF4442 PF14539.6 EGD98907.1 - 0.0035 17.5 0.0 0.0052 16.9 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4442) WD40 PF00400.32 EGD98908.1 - 7e-09 36.2 15.1 0.0043 17.9 0.0 6.0 5 0 0 5 5 5 3 WD domain, G-beta repeat Zn_ribbon_17 PF17120.5 EGD98908.1 - 3.6e-07 29.7 17.1 3.6e-07 29.7 17.1 2.4 2 0 0 2 2 2 1 Zinc-ribbon, C4HC2 type RWD PF05773.22 EGD98908.1 - 0.0021 18.3 0.0 0.0063 16.8 0.0 1.8 1 0 0 1 1 1 1 RWD domain zf-RING_2 PF13639.6 EGD98908.1 - 0.045 14.1 13.8 0.13 12.6 13.8 1.9 1 0 0 1 1 1 0 Ring finger domain zf-C3HC4_2 PF13923.6 EGD98908.1 - 0.29 11.0 9.9 0.79 9.6 9.9 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EGD98908.1 - 0.45 10.4 9.1 1.2 9.1 9.1 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) UQ_con PF00179.26 EGD98909.1 - 3.8e-47 159.5 0.0 4.2e-47 159.3 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EGD98909.1 - 0.0022 17.7 0.0 0.0029 17.3 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.13 EGD98909.1 - 0.012 15.5 0.1 0.023 14.6 0.1 1.5 1 1 0 1 1 1 0 UEV domain RWD PF05773.22 EGD98909.1 - 0.021 15.1 0.0 0.027 14.7 0.0 1.3 1 0 0 1 1 1 0 RWD domain Ribosomal_L24e PF01246.20 EGD98910.1 - 4e-29 100.6 1.3 5.1e-29 100.3 0.1 1.8 2 0 0 2 2 2 1 Ribosomal protein L24e Ribosomal_S30 PF04758.14 EGD98911.1 - 4.8e-30 103.5 8.6 5.2e-30 103.4 8.6 1.0 1 0 0 1 1 1 1 Ribosomal protein S30 Acetyltransf_1 PF00583.25 EGD98912.1 - 2.5e-11 43.8 0.1 3.7e-11 43.3 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EGD98912.1 - 4.6e-07 29.8 0.0 6.9e-07 29.2 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EGD98912.1 - 4.5e-06 27.0 0.3 7.4e-06 26.3 0.3 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Lyase_1 PF00206.20 EGD98914.1 - 5.9e-106 354.4 0.0 9.3e-106 353.7 0.0 1.2 1 0 0 1 1 1 1 Lyase FumaraseC_C PF10415.9 EGD98914.1 - 9.2e-21 74.0 0.0 2.1e-20 72.9 0.0 1.7 1 0 0 1 1 1 1 Fumarase C C-terminus Abhydrolase_3 PF07859.13 EGD98915.1 - 9.6e-50 169.4 0.1 1.3e-49 168.9 0.1 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 EGD98915.1 - 1.5e-05 24.0 0.1 4.7e-05 22.5 0.1 1.7 1 1 0 1 1 1 1 Carboxylesterase family Peptidase_S9 PF00326.21 EGD98915.1 - 0.00068 19.2 0.0 0.0016 17.9 0.0 1.5 1 1 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_6 PF12697.7 EGD98915.1 - 0.0087 16.7 2.5 0.024 15.3 2.2 1.7 2 0 0 2 2 2 1 Alpha/beta hydrolase family Esterase_phd PF10503.9 EGD98915.1 - 0.014 14.9 0.1 0.023 14.2 0.1 1.2 1 0 0 1 1 1 0 Esterase PHB depolymerase FMO-like PF00743.19 EGD98916.1 - 7.4e-99 331.6 0.0 1e-98 331.1 0.0 1.0 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 EGD98916.1 - 8.4e-16 58.1 0.0 3.1e-13 49.6 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EGD98916.1 - 1e-10 41.3 0.0 1.2e-07 31.3 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EGD98916.1 - 1.6e-09 37.4 0.0 1.8e-08 33.9 0.0 2.1 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 EGD98916.1 - 1.5e-06 28.3 0.1 0.0041 17.1 0.1 3.1 2 1 0 2 2 2 2 FAD-NAD(P)-binding NAD_binding_8 PF13450.6 EGD98916.1 - 0.00011 22.4 0.0 0.00032 20.9 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EGD98916.1 - 0.00031 20.4 1.8 4.3 6.8 0.9 3.1 2 1 0 3 3 3 2 FAD dependent oxidoreductase Pyr_redox PF00070.27 EGD98916.1 - 0.001 19.6 0.2 0.1 13.2 0.0 2.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase p450 PF00067.22 EGD98917.1 - 3.5e-68 230.5 0.0 4.3e-68 230.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 AA_permease_2 PF13520.6 EGD98918.1 - 1.8e-84 284.0 32.5 2.2e-84 283.8 32.5 1.0 1 0 0 1 1 1 1 Amino acid permease SseC PF04888.12 EGD98918.1 - 0.24 10.9 1.2 0.54 9.8 0.1 1.9 2 0 0 2 2 2 0 Secretion system effector C (SseC) like family PsbN PF02468.15 EGD98918.1 - 0.85 9.5 4.0 0.71 9.8 1.3 2.4 2 0 0 2 2 2 0 Photosystem II reaction centre N protein (psbN) Myb_DNA-binding PF00249.31 EGD98919.1 - 3.6e-33 113.5 10.4 3.6e-12 46.3 0.5 3.2 3 0 0 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EGD98919.1 - 1e-26 92.9 9.8 1.5e-14 54.0 0.3 3.2 1 1 2 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 EGD98919.1 - 0.00013 21.8 0.6 0.023 14.6 0.0 3.1 3 0 0 3 3 3 1 Myb DNA-binding like Atg29_N PF18388.1 EGD98919.1 - 0.0047 16.7 8.5 0.066 13.0 1.1 2.7 3 0 0 3 3 3 2 Atg29 N-terminal domain Myb_DNA-bind_4 PF13837.6 EGD98919.1 - 0.039 14.3 10.1 1.3 9.5 0.7 3.6 3 1 0 3 3 3 0 Myb/SANT-like DNA-binding domain SANT_DAMP1_like PF16282.5 EGD98919.1 - 0.093 12.9 1.7 0.36 11.0 0.0 2.4 2 1 1 3 3 3 0 SANT/Myb-like domain of DAMP1 PriCT_2 PF08707.11 EGD98919.1 - 0.68 10.3 3.4 15 6.0 2.2 3.3 2 1 1 3 3 3 0 Primase C terminal 2 (PriCT-2) Rap1_C PF11626.8 EGD98919.1 - 1.2 9.3 5.2 2.7 8.1 0.5 2.5 1 1 1 2 2 2 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain Complex1_30kDa PF00329.19 EGD98920.1 - 8.6e-46 155.5 0.0 1.2e-45 155.0 0.0 1.2 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 30 Kd subunit zf-RING_4 PF14570.6 EGD98921.1 - 2.2e-19 69.0 13.3 4.2e-19 68.1 13.3 1.5 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-C3HC4_3 PF13920.6 EGD98921.1 - 2.6e-06 27.2 7.9 4.5e-06 26.4 7.9 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) RRM_1 PF00076.22 EGD98921.1 - 0.00017 21.3 0.0 0.00047 19.9 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-RING_2 PF13639.6 EGD98921.1 - 0.00087 19.6 11.3 0.0017 18.7 11.3 1.5 1 0 0 1 1 1 1 Ring finger domain Baculo_IE-1 PF05290.11 EGD98921.1 - 0.0022 17.9 4.9 0.0044 17.0 4.9 1.4 1 0 0 1 1 1 1 Baculovirus immediate-early protein (IE-0) ALP_N PF17989.1 EGD98921.1 - 0.06 13.5 0.0 0.18 12.0 0.0 1.7 1 0 0 1 1 1 0 Actin like proteins N terminal domain zf-C3HC4 PF00097.25 EGD98921.1 - 0.23 11.4 12.7 0.45 10.4 12.7 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EGD98921.1 - 0.25 11.3 9.7 2.2 8.2 10.2 2.1 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-UDP PF14569.6 EGD98921.1 - 1.4 9.1 4.7 2.8 8.1 4.7 1.4 1 0 0 1 1 1 0 Zinc-binding RING-finger zf-RING_UBOX PF13445.6 EGD98921.1 - 5 7.2 10.8 11 6.1 10.8 1.6 1 0 0 1 1 1 0 RING-type zinc-finger DZR PF12773.7 EGD98921.1 - 6.2 6.9 9.3 31 4.7 9.7 1.9 1 1 1 2 2 2 0 Double zinc ribbon E1_dh PF00676.20 EGD98922.1 - 8.2e-91 304.1 0.2 1e-90 303.8 0.2 1.1 1 0 0 1 1 1 1 Dehydrogenase E1 component TPP_enzyme_C PF02775.21 EGD98922.1 - 0.00058 19.7 0.1 0.0021 17.9 0.1 2.0 1 1 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain DXP_synthase_N PF13292.6 EGD98922.1 - 0.023 13.9 0.0 0.04 13.1 0.0 1.4 1 0 0 1 1 1 0 1-deoxy-D-xylulose-5-phosphate synthase XFP_N PF09364.10 EGD98922.1 - 0.055 12.3 0.0 0.16 10.7 0.0 1.7 2 0 0 2 2 2 0 XFP N-terminal domain Ubie_methyltran PF01209.18 EGD98923.1 - 3.2e-77 259.0 0.0 5.5e-77 258.2 0.0 1.3 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.6 EGD98923.1 - 3.7e-16 59.6 0.0 6.8e-16 58.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EGD98923.1 - 6.7e-15 55.5 0.0 1.4e-14 54.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EGD98923.1 - 9.3e-13 48.2 0.0 1.3e-12 47.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EGD98923.1 - 1e-10 42.2 0.0 1.8e-10 41.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EGD98923.1 - 1.2e-05 25.2 0.0 1.6e-05 24.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.15 EGD98923.1 - 0.053 13.4 0.0 0.18 11.6 0.0 1.8 2 0 0 2 2 2 0 Hypothetical methyltransferase SIS PF01380.22 EGD98924.1 - 1.7e-12 47.3 0.0 6.3e-12 45.5 0.0 2.0 1 1 0 1 1 1 1 SIS domain SIS_2 PF13580.6 EGD98924.1 - 4.1e-05 23.6 0.0 9.5e-05 22.4 0.0 1.7 1 0 0 1 1 1 1 SIS domain BATS PF06968.13 EGD98924.1 - 0.033 14.3 0.0 0.17 12.1 0.0 2.0 2 0 0 2 2 2 0 Biotin and Thiamin Synthesis associated domain CheX PF13690.6 EGD98924.1 - 0.15 12.3 1.8 9.1 6.5 0.1 3.1 3 0 0 3 3 3 0 Chemotaxis phosphatase CheX BUD22 PF09073.10 EGD98925.1 - 2.4e-101 340.2 23.3 3.3e-101 339.8 23.3 1.2 1 0 0 1 1 1 1 BUD22 PNP_UDP_1 PF01048.20 EGD98926.1 - 1.1e-38 132.8 0.0 1.3e-38 132.5 0.0 1.0 1 0 0 1 1 1 1 Phosphorylase superfamily Glyco_hydro_3_C PF01915.22 EGD98927.1 - 1.2e-48 165.8 0.0 2.2e-48 165.0 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 EGD98927.1 - 5.9e-32 111.3 0.0 7e-30 104.5 0.0 2.2 1 1 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 EGD98927.1 - 1.5e-18 66.7 0.2 2.7e-18 65.8 0.2 1.5 1 0 0 1 1 1 1 Fibronectin type III-like domain DUF572 PF04502.13 EGD98928.1 - 1.1e-69 235.6 0.5 1.2e-69 235.4 0.5 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF572) PTPA PF03095.15 EGD98929.1 - 3.1e-118 394.6 0.0 3.6e-118 394.4 0.0 1.0 1 0 0 1 1 1 1 Phosphotyrosyl phosphate activator (PTPA) protein CENP-F_leu_zip PF10473.9 EGD98931.1 - 0.00047 20.2 22.9 0.00047 20.2 22.9 9.4 2 1 8 10 10 10 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ERM PF00769.19 EGD98931.1 - 0.0013 18.6 25.4 0.0013 18.6 25.4 6.2 2 1 3 5 5 5 1 Ezrin/radixin/moesin family Filament PF00038.21 EGD98931.1 - 0.0019 17.8 156.7 0.029 14.0 31.4 5.4 1 1 3 4 4 4 3 Intermediate filament protein DUF4200 PF13863.6 EGD98931.1 - 0.0059 17.0 17.0 0.0059 17.0 17.0 10.4 2 1 10 12 12 12 3 Domain of unknown function (DUF4200) Pox_A_type_inc PF04508.12 EGD98931.1 - 0.81 9.6 19.5 0.53 10.2 0.1 8.3 10 0 0 10 10 10 0 Viral A-type inclusion protein repeat DUF3287 PF11690.8 EGD98931.1 - 2.6 7.8 7.3 0.66 9.7 0.2 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF3287) Rad4 PF03835.15 EGD98932.1 - 2.9e-36 124.4 0.0 5.5e-36 123.5 0.0 1.4 1 0 0 1 1 1 1 Rad4 transglutaminase-like domain BHD_3 PF10405.9 EGD98932.1 - 7.4e-28 96.8 0.0 1.5e-27 95.8 0.0 1.6 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 3 BHD_1 PF10403.9 EGD98932.1 - 1.4e-19 69.7 0.1 3.3e-19 68.5 0.1 1.7 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 1 BHD_2 PF10404.9 EGD98932.1 - 4.2e-16 59.7 0.8 4.2e-16 59.7 0.8 2.9 3 1 0 3 3 3 1 Rad4 beta-hairpin domain 2 Transglut_core PF01841.19 EGD98932.1 - 0.082 13.4 0.0 0.26 11.8 0.0 1.9 1 0 0 1 1 1 0 Transglutaminase-like superfamily BSD PF03909.17 EGD98934.1 - 1.3e-19 69.9 0.6 3.1e-19 68.7 0.6 1.7 1 0 0 1 1 1 1 BSD domain Suf PF05843.14 EGD98934.1 - 0.009 16.0 2.6 0.013 15.5 2.6 1.2 1 0 0 1 1 1 1 Suppressor of forked protein (Suf) TPR_2 PF07719.17 EGD98934.1 - 4.1 7.7 5.2 1.8 8.9 0.2 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat USP7_ICP0_bdg PF12436.8 EGD98935.1 - 3.6e-41 141.1 0.0 6.1e-41 140.3 0.0 1.4 1 0 0 1 1 1 1 ICP0-binding domain of Ubiquitin-specific protease 7 UCH PF00443.29 EGD98935.1 - 1.1e-33 116.8 0.3 1.6e-33 116.3 0.3 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EGD98935.1 - 2.9e-08 33.7 0.1 5e-07 29.6 0.1 2.3 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Ran-binding PF05508.11 EGD98936.1 - 2.9e-111 371.4 0.0 8.1e-98 327.2 0.0 2.1 1 1 1 2 2 2 2 RanGTP-binding protein CTP_transf_like PF01467.26 EGD98937.1 - 9.6e-25 87.5 0.0 1.4e-24 86.9 0.0 1.2 1 0 0 1 1 1 1 Cytidylyltransferase-like GTP_EFTU PF00009.27 EGD98938.1 - 2.1e-40 138.4 0.0 3e-40 137.8 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 EGD98938.1 - 5.5e-30 103.9 0.1 1.2e-29 102.9 0.1 1.6 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 EGD98938.1 - 8.6e-10 38.9 0.4 2e-09 37.7 0.4 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EGD98938.1 - 0.063 13.4 0.0 0.19 11.8 0.0 1.8 1 1 0 1 1 1 0 50S ribosome-binding GTPase Aminotran_1_2 PF00155.21 EGD98939.1 - 4.2e-40 138.0 0.0 5.2e-40 137.7 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 EGD98939.1 - 0.04 12.9 0.0 0.97 8.3 0.0 2.1 2 0 0 2 2 2 0 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 EGD98939.1 - 0.12 10.9 0.0 0.16 10.5 0.0 1.2 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme Aminotran_3 PF00202.21 EGD98940.1 - 9.3e-41 139.8 0.0 1.6e-19 69.9 0.0 3.1 2 1 0 2 2 2 2 Aminotransferase class-III AAA_26 PF13500.6 EGD98940.1 - 6e-19 68.7 0.0 9.4e-19 68.0 0.0 1.2 1 0 0 1 1 1 1 AAA domain BATS PF06968.13 EGD98941.1 - 5.4e-22 77.7 0.1 2e-21 75.9 0.0 2.0 2 0 0 2 2 2 1 Biotin and Thiamin Synthesis associated domain Radical_SAM PF04055.21 EGD98941.1 - 6.5e-15 55.9 0.0 1.5e-14 54.7 0.1 1.6 2 0 0 2 2 2 1 Radical SAM superfamily Dus PF01207.17 EGD98942.1 - 0.063 12.4 0.0 0.1 11.6 0.0 1.3 1 1 0 1 1 1 0 Dihydrouridine synthase (Dus) GST_N PF02798.20 EGD98943.1 - 2.5e-10 40.6 0.0 5.2e-10 39.5 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EGD98943.1 - 6.2e-10 39.3 0.0 1.4e-09 38.1 0.0 1.6 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 EGD98943.1 - 5.2e-09 36.4 0.0 8.2e-09 35.8 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EGD98943.1 - 1.3e-08 34.9 0.0 3.8e-08 33.4 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EGD98943.1 - 1.7e-06 28.1 0.2 4.9e-06 26.7 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EGD98943.1 - 0.00037 20.5 0.2 0.00077 19.4 0.2 1.6 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain TYW3 PF02676.14 EGD98943.1 - 0.073 12.4 0.0 0.1 11.9 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase TYW3 FAA_hydrolase PF01557.18 EGD98944.1 - 2.1e-55 187.7 0.0 2.9e-55 187.3 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family FAA_hydrolase_N PF09298.11 EGD98944.1 - 4.7e-32 110.3 0.0 8e-32 109.6 0.0 1.4 1 0 0 1 1 1 1 Fumarylacetoacetase N-terminal HgmA PF04209.13 EGD98945.1 - 6.2e-174 578.7 0.0 7.6e-174 578.4 0.0 1.0 1 0 0 1 1 1 1 homogentisate 1,2-dioxygenase TPR_17 PF13431.6 EGD98946.1 - 0.00041 20.5 0.1 0.031 14.6 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat Glyoxalase PF00903.25 EGD98947.1 - 8.3e-25 87.5 0.9 1.3e-17 64.2 0.0 2.2 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 EGD98947.1 - 1.3e-14 54.3 0.2 5.9e-07 29.7 0.2 2.4 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_3 PF13468.6 EGD98947.1 - 1.2e-07 32.1 0.1 0.00073 19.7 0.2 2.7 2 1 0 2 2 2 2 Glyoxalase-like domain Glyoxalase_5 PF14696.6 EGD98947.1 - 0.00087 19.5 0.2 0.013 15.7 0.2 2.3 1 1 0 1 1 1 1 Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal DUF4844 PF16133.5 EGD98947.1 - 0.029 14.9 0.0 0.14 12.7 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4844) COX15-CtaA PF02628.15 EGD98948.1 - 1.3e-97 326.8 3.7 1.7e-97 326.4 3.7 1.1 1 0 0 1 1 1 1 Cytochrome oxidase assembly protein PQ-loop PF04193.14 EGD98948.1 - 2 8.3 4.8 15 5.4 0.1 3.0 3 0 0 3 3 3 0 PQ loop repeat Prok-RING_2 PF14445.6 EGD98949.1 - 0.2 11.8 5.9 0.36 11.0 5.9 1.3 1 0 0 1 1 1 0 Prokaryotic RING finger family 2 zf-RING_4 PF14570.6 EGD98949.1 - 0.48 10.3 4.2 1 9.2 4.2 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RanBP PF00641.18 EGD98949.1 - 0.75 9.2 9.8 0.02 14.2 3.4 1.7 2 0 0 2 2 2 0 Zn-finger in Ran binding protein and others tRNA-synt_2 PF00152.20 EGD98950.1 - 2.4e-78 263.4 0.5 3.2e-78 263.0 0.5 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 EGD98950.1 - 3e-12 46.4 0.0 8.3e-12 44.9 0.0 1.8 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 EGD98950.1 - 1.2e-05 24.9 0.1 0.018 14.5 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) MSP1b PF03429.13 EGD98950.1 - 1 7.4 4.6 1.4 6.9 4.6 1.2 1 0 0 1 1 1 0 Major surface protein 1B Dynamin_N PF00350.23 EGD98951.1 - 2.2e-23 83.2 0.0 7.3e-23 81.5 0.0 1.9 1 1 0 1 1 1 1 Dynamin family Dynamin_M PF01031.20 EGD98951.1 - 1.9e-10 40.4 0.0 0.00038 19.8 0.0 3.2 3 0 0 3 3 3 2 Dynamin central region MMR_HSR1 PF01926.23 EGD98951.1 - 0.0018 18.4 0.0 0.018 15.1 0.0 2.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase Roc PF08477.13 EGD98951.1 - 0.011 15.9 0.1 0.049 13.8 0.1 2.1 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EGD98951.1 - 0.12 11.9 0.1 0.31 10.6 0.1 1.7 1 0 0 1 1 1 0 Ras family NTP_transferase PF00483.23 EGD98952.1 - 3.5e-31 108.7 0.0 4.6e-31 108.3 0.0 1.1 1 0 0 1 1 1 1 Nucleotidyl transferase Hexapep PF00132.24 EGD98952.1 - 1e-08 34.6 7.4 4e-06 26.3 0.1 3.5 3 1 0 3 3 3 2 Bacterial transferase hexapeptide (six repeats) NTP_transf_3 PF12804.7 EGD98952.1 - 1.9e-08 34.9 0.0 2.8e-08 34.3 0.0 1.3 1 0 0 1 1 1 1 MobA-like NTP transferase domain IspD PF01128.19 EGD98952.1 - 0.01 15.6 0.0 0.034 13.9 0.0 1.7 2 0 0 2 2 2 0 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase Hexapep_2 PF14602.6 EGD98952.1 - 0.076 12.8 2.0 0.52 10.1 0.0 3.0 3 0 0 3 3 3 0 Hexapeptide repeat of succinyl-transferase Bys1 PF04681.12 EGD98953.1 - 3.7e-12 46.4 0.1 4.2e-12 46.3 0.1 1.0 1 0 0 1 1 1 1 Blastomyces yeast-phase-specific protein Ribosomal_L50 PF10501.9 EGD98955.1 - 0.074 13.2 0.1 0.16 12.1 0.1 1.6 1 0 0 1 1 1 0 Ribosomal subunit 39S Putative_PNPOx PF01243.20 EGD98956.1 - 2.2e-09 37.4 0.0 0.00027 21.0 0.0 2.8 3 0 0 3 3 3 2 Pyridoxamine 5'-phosphate oxidase FAD_binding_6 PF00970.24 EGD98956.1 - 0.00014 22.2 0.0 0.014 15.8 0.0 2.6 2 1 0 2 2 2 1 Oxidoreductase FAD-binding domain zf-RING_2 PF13639.6 EGD98957.1 - 1.5e-08 34.8 3.8 2.4e-08 34.2 3.8 1.3 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 EGD98957.1 - 2.8e-06 27.5 4.2 5.3e-05 23.4 4.2 2.3 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 EGD98957.1 - 0.00021 21.3 0.8 0.00034 20.6 0.8 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.6 EGD98957.1 - 0.00052 20.0 6.7 0.00092 19.2 6.7 1.4 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 EGD98957.1 - 0.0073 16.1 4.6 0.028 14.2 4.4 1.9 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EGD98957.1 - 0.023 14.5 2.5 0.3 11.0 2.3 2.1 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zinc_ribbon_9 PF14369.6 EGD98957.1 - 0.024 14.9 0.2 0.055 13.7 0.2 1.6 1 0 0 1 1 1 0 zinc-ribbon zf-RING_11 PF17123.5 EGD98957.1 - 0.075 12.8 3.3 0.14 11.9 3.3 1.5 1 0 0 1 1 1 0 RING-like zinc finger Prok-RING_4 PF14447.6 EGD98957.1 - 0.47 10.4 4.1 5.7 6.9 0.9 2.3 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 Atx10homo_assoc PF09759.9 EGD98958.1 - 1.1e-31 108.7 0.5 1.1e-31 108.7 0.5 1.9 2 0 0 2 2 2 1 Spinocerebellar ataxia type 10 protein domain DHHC PF01529.20 EGD98959.1 - 6e-31 107.3 8.6 6e-31 107.3 8.6 1.9 2 1 0 2 2 2 1 DHHC palmitoyltransferase Rap1_C PF11626.8 EGD98960.1 - 1.8e-20 72.8 0.1 2.3e-18 66.0 0.0 2.5 2 0 0 2 2 2 1 TRF2-interacting telomeric protein/Rap1 - C terminal domain Myb_DNA-bind_2 PF08914.11 EGD98960.1 - 9.6e-20 70.5 8.0 1.2e-19 70.2 0.6 2.9 2 1 1 3 3 3 1 Rap1 Myb domain BRCT_2 PF16589.5 EGD98960.1 - 1e-11 45.1 0.0 2.2e-11 44.0 0.0 1.6 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain Rap1-DNA-bind PF09197.10 EGD98960.1 - 8.7e-07 29.5 9.0 0.00037 21.0 1.2 3.5 3 1 0 3 3 3 2 Rap1, DNA-binding LIG3_BRCT PF16759.5 EGD98960.1 - 0.00056 20.1 0.2 0.011 16.1 0.0 2.5 2 0 0 2 2 2 1 DNA ligase 3 BRCT domain Chromo_shadow PF01393.19 EGD98961.1 - 6.3e-20 71.0 0.2 2.1e-16 59.7 0.0 2.3 2 0 0 2 2 2 2 Chromo shadow domain Chromo PF00385.24 EGD98961.1 - 6.5e-14 51.6 0.1 1.5e-13 50.4 0.1 1.7 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain YL1 PF05764.13 EGD98961.1 - 1.9 8.6 11.8 2.2 8.3 11.8 1.1 1 0 0 1 1 1 0 YL1 nuclear protein Cpn60_TCP1 PF00118.24 EGD98962.1 - 1.4e-159 531.8 4.4 1.6e-159 531.7 4.4 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Enolase_N PF03952.16 EGD98962.1 - 0.062 13.5 3.2 6.4 7.0 0.1 3.3 3 0 0 3 3 3 0 Enolase, N-terminal domain DUF3295 PF11702.8 EGD98966.1 - 9.1e-175 582.7 40.1 9.1e-175 582.7 40.1 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF3295) DUF1752 PF08550.10 EGD98966.1 - 1.1e-11 44.3 2.9 3e-11 42.9 2.9 1.8 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) ParBc PF02195.18 EGD98966.1 - 0.0036 17.5 0.4 0.29 11.5 0.1 3.4 3 1 0 3 3 3 1 ParB-like nuclease domain Polysacc_deac_1 PF01522.21 EGD98969.1 - 1.5e-19 70.1 0.0 1e-17 64.2 0.0 2.2 2 0 0 2 2 2 2 Polysaccharide deacetylase RWD PF05773.22 EGD98970.1 - 0.011 16.1 0.1 0.7 10.2 0.0 2.5 2 0 0 2 2 2 0 RWD domain zf-RRPl_C4 PF17026.5 EGD98970.1 - 0.14 12.3 2.0 1.8 8.7 0.2 2.5 2 0 0 2 2 2 0 Putative ribonucleoprotein zinc-finger pf C4 type Pox_MCEL PF03291.16 EGD98972.1 - 7.6e-63 212.6 0.0 2.3e-60 204.5 0.0 3.1 1 1 0 1 1 1 1 mRNA capping enzyme Rsm1 PF08600.10 EGD98972.1 - 1e-24 86.5 0.2 1.1e-23 83.2 0.2 3.0 1 0 0 1 1 1 1 Rsm1-like zf-Nse PF11789.8 EGD98972.1 - 1.6e-20 72.6 1.8 3.1e-20 71.7 1.8 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-C3HC PF07967.13 EGD98972.1 - 3.1e-20 72.6 3.3 6.3e-19 68.3 0.1 4.0 3 1 1 4 4 4 1 C3HC zinc finger-like Methyltransf_25 PF13649.6 EGD98972.1 - 1.5e-08 35.2 0.0 0.0041 17.8 0.0 2.9 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_12 PF08242.12 EGD98972.1 - 7.2e-08 33.1 5.0 2.7e-07 31.2 0.0 4.3 4 2 1 5 5 5 1 Methyltransferase domain Methyltransf_11 PF08241.12 EGD98972.1 - 2e-05 25.2 0.0 0.096 13.3 0.0 3.0 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_31 PF13847.6 EGD98972.1 - 0.00031 20.6 0.0 0.24 11.2 0.0 2.5 2 0 0 2 2 2 2 Methyltransferase domain NNMT_PNMT_TEMT PF01234.17 EGD98972.1 - 0.001 18.3 0.0 0.002 17.3 0.0 1.4 1 0 0 1 1 1 1 NNMT/PNMT/TEMT family zf-RING_UBOX PF13445.6 EGD98972.1 - 0.003 17.5 2.4 0.0045 17.0 0.0 2.6 2 1 1 3 3 3 1 RING-type zinc-finger Mito_carr PF00153.27 EGD98973.1 - 9.7e-37 124.8 0.9 3.1e-18 65.5 0.1 2.0 2 0 0 2 2 2 2 Mitochondrial carrier protein Meiotic_rec114 PF03525.14 EGD98975.1 - 5.6e-10 38.7 1.3 1.5e-07 30.7 0.0 2.9 3 0 0 3 3 3 2 Meiotic recombination protein rec114 HS1_rep PF02218.15 EGD98975.1 - 0.06 13.7 1.3 0.13 12.6 1.3 1.5 1 0 0 1 1 1 0 Repeat in HS1/Cortactin Transp_cyt_pur PF02133.15 EGD98976.1 - 1e-38 133.3 7.6 1.5e-19 70.1 1.0 2.9 1 1 2 3 3 3 3 Permease for cytosine/purines, uracil, thiamine, allantoin Tfb2 PF03849.14 EGD98977.1 - 4.9e-135 450.1 0.0 5.8e-135 449.8 0.0 1.0 1 0 0 1 1 1 1 Transcription factor Tfb2 Tfb2_C PF18307.1 EGD98977.1 - 2e-18 66.6 0.0 4.3e-18 65.5 0.0 1.6 1 0 0 1 1 1 1 Transcription factor Tfb2 (p52) C-terminal domain Helicase_C_3 PF13625.6 EGD98977.1 - 1.1e-05 25.6 0.0 0.00012 22.2 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain PhzC-PhzF PF02567.16 EGD98979.1 - 3.8e-39 134.9 0.5 1.2e-38 133.2 0.5 1.7 1 1 0 1 1 1 1 Phenazine biosynthesis-like protein TIMELESS PF04821.14 EGD98980.1 - 6.8e-84 281.4 1.6 1.6e-83 280.2 0.0 2.2 2 0 0 2 2 2 1 Timeless protein TIMELESS_C PF05029.13 EGD98980.1 - 1.2e-39 137.0 11.7 9.5e-37 127.4 0.0 3.6 2 1 1 3 3 3 3 Timeless protein C terminal region 3HCDH_N PF02737.18 EGD98981.1 - 7.1e-52 175.9 0.8 9.4e-52 175.5 0.8 1.2 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.22 EGD98981.1 - 4e-34 117.1 0.0 8.9e-34 116.0 0.0 1.6 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain NAD_binding_2 PF03446.15 EGD98981.1 - 0.00014 22.1 0.4 0.00039 20.6 0.4 1.9 1 1 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Sacchrp_dh_NADP PF03435.18 EGD98981.1 - 0.00023 21.4 0.1 0.00037 20.8 0.1 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain ApbA PF02558.16 EGD98981.1 - 0.00041 20.0 0.1 0.01 15.5 0.0 2.2 2 0 0 2 2 2 1 Ketopantoate reductase PanE/ApbA UDPG_MGDP_dh_N PF03721.14 EGD98981.1 - 0.006 16.2 0.0 0.01 15.4 0.0 1.4 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain DAO PF01266.24 EGD98981.1 - 0.017 14.7 0.0 0.025 14.2 0.0 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EGD98981.1 - 0.026 13.8 0.0 0.034 13.4 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_Gly3P_dh_N PF01210.23 EGD98981.1 - 0.057 13.4 0.1 0.11 12.5 0.1 1.5 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 2-Hacid_dh_C PF02826.19 EGD98981.1 - 0.061 12.7 0.9 0.97 8.8 0.1 2.1 1 1 1 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain F420_oxidored PF03807.17 EGD98981.1 - 0.11 13.1 1.7 0.39 11.3 1.6 2.1 1 1 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Pyr_redox PF00070.27 EGD98981.1 - 0.15 12.6 0.1 0.37 11.4 0.0 1.7 2 0 0 2 2 1 0 Pyridine nucleotide-disulphide oxidoreductase RsbU_N PF08673.10 EGD98981.1 - 0.2 11.8 0.1 0.41 10.8 0.1 1.5 1 0 0 1 1 1 0 Phosphoserine phosphatase RsbU, N-terminal domain Actin PF00022.19 EGD98984.1 - 1.8e-103 346.3 0.0 1.5e-102 343.3 0.0 1.9 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 EGD98984.1 - 0.15 10.8 0.0 2.9 6.6 0.0 2.2 2 0 0 2 2 2 0 MreB/Mbl protein GCIP PF13324.6 EGD98985.1 - 2.4e-26 92.9 5.2 2.4e-26 92.9 5.2 1.4 2 0 0 2 2 2 1 Grap2 and cyclin-D-interacting Sigma70_ner PF04546.13 EGD98985.1 - 0.0018 18.2 2.0 0.0027 17.6 2.0 1.4 1 0 0 1 1 1 1 Sigma-70, non-essential region DUF5617 PF18493.1 EGD98985.1 - 0.021 14.9 0.1 3.8 7.7 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF5617) PMC2NT PF08066.12 EGD98985.1 - 0.39 11.4 6.4 7.6 7.3 0.0 3.7 2 1 2 4 4 4 0 PMC2NT (NUC016) domain LRR_8 PF13855.6 EGD98986.1 - 1.5e-30 104.7 39.6 2.4e-09 36.8 2.1 8.1 7 1 2 9 9 9 7 Leucine rich repeat LRR_4 PF12799.7 EGD98986.1 - 2.4e-24 85.0 50.0 9.8e-06 25.8 0.5 10.9 5 4 7 13 13 13 10 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EGD98986.1 - 0.00025 21.2 35.2 0.93 10.3 0.0 12.4 11 3 0 11 11 11 1 Leucine Rich Repeat LRR_9 PF14580.6 EGD98986.1 - 0.0038 16.7 19.5 0.55 9.7 0.6 4.7 3 2 2 5 5 5 3 Leucine-rich repeat TFIIA PF03153.13 EGD98986.1 - 7.5 6.4 10.0 11 5.8 10.0 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit GrpE PF01025.19 EGD98987.1 - 0.03 14.0 6.7 1.4 8.6 0.3 2.3 2 0 0 2 2 2 0 GrpE TMF_TATA_bd PF12325.8 EGD98987.1 - 0.1 12.8 9.5 0.2 11.9 9.5 1.5 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding Mto2_bdg PF12808.7 EGD98987.1 - 0.21 11.9 6.9 0.095 13.0 1.7 2.6 2 0 0 2 2 2 0 Micro-tubular organiser Mto1 C-term Mto2-binding region Ribosomal_L13e PF01294.18 EGD98988.1 - 5e-78 261.1 2.5 7.4e-78 260.5 2.5 1.2 1 0 0 1 1 1 1 Ribosomal protein L13e DUF4404 PF14357.6 EGD98989.1 - 1.2 9.8 5.7 6 7.6 2.2 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4404) DUF4635 PF15466.6 EGD98989.1 - 2.6 7.5 4.6 15 5.1 1.3 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4635) Oxidored-like PF09791.9 EGD98990.1 - 4.7e-24 83.8 4.0 1.1e-23 82.7 4.0 1.6 1 0 0 1 1 1 1 Oxidoreductase-like protein, N-terminal DUF5522 PF17653.1 EGD98990.1 - 0.072 13.1 3.1 0.17 11.9 3.1 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5522) KAP PF05804.12 EGD98991.1 - 0.0036 15.5 0.0 0.022 12.9 0.0 1.9 2 0 0 2 2 2 2 Kinesin-associated protein (KAP) DPM3 PF08285.11 EGD98992.1 - 1.1e-32 112.1 0.2 1.2e-32 112.0 0.2 1.0 1 0 0 1 1 1 1 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) Yip1 PF04893.17 EGD98992.1 - 0.054 13.2 2.3 0.07 12.8 2.3 1.0 1 0 0 1 1 1 0 Yip1 domain DUF2523 PF10734.9 EGD98992.1 - 0.06 13.9 0.1 0.13 12.9 0.0 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF2523) Pribosyltran PF00156.27 EGD98993.1 - 1.1e-05 25.0 0.0 1.7e-05 24.4 0.0 1.2 1 0 0 1 1 1 1 Phosphoribosyl transferase domain SR-25 PF10500.9 EGD98995.1 - 0.00023 20.9 6.0 0.00024 20.8 6.0 1.1 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein DUF4604 PF15377.6 EGD98995.1 - 0.0034 17.8 6.6 0.0043 17.5 6.6 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4604) Peptidase_S49_N PF08496.10 EGD98995.1 - 1.1 9.3 4.6 1.5 8.9 4.6 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Ferlin_C PF16165.5 EGD98995.1 - 1.6 8.7 6.6 2.3 8.1 6.6 1.3 1 0 0 1 1 1 0 Ferlin C-terminus HSF_DNA-bind PF00447.17 EGD98996.1 - 1.9e-30 105.3 1.2 7.7e-30 103.4 0.5 2.0 2 0 0 2 2 2 1 HSF-type DNA-binding GREB1 PF15782.5 EGD98996.1 - 0.0064 13.7 6.3 0.011 13.0 6.3 1.2 1 0 0 1 1 1 1 Gene regulated by oestrogen in breast cancer GCD14_N PF14801.6 EGD98996.1 - 0.18 11.6 0.0 0.34 10.8 0.0 1.4 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit N-term DUF3245 PF11595.8 EGD98998.1 - 1.7e-41 142.2 10.6 2.5e-41 141.6 10.6 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3245) ATP-grasp_2 PF08442.10 EGD98999.1 - 1.1e-72 243.8 0.5 2e-72 243.0 0.5 1.3 1 0 0 1 1 1 1 ATP-grasp domain Ligase_CoA PF00549.19 EGD98999.1 - 4e-25 88.4 0.7 1.7e-24 86.4 0.3 2.1 2 0 0 2 2 2 1 CoA-ligase ATP-grasp_5 PF13549.6 EGD98999.1 - 2.2e-06 27.3 0.8 3.8e-06 26.5 0.2 1.6 2 0 0 2 2 2 1 ATP-grasp domain GARS_A PF01071.19 EGD98999.1 - 0.0041 16.9 1.4 0.8 9.4 0.1 2.6 2 1 0 2 2 2 2 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain Succ_CoA_lig PF13607.6 EGD98999.1 - 0.013 15.3 0.3 1.9 8.3 0.1 2.5 1 1 1 2 2 2 0 Succinyl-CoA ligase like flavodoxin domain VID27_N PF17748.1 EGD98999.1 - 0.14 12.0 0.8 0.24 11.2 0.8 1.3 1 0 0 1 1 1 0 VID27 N-terminal region adh_short PF00106.25 EGD99000.1 - 1.4e-40 138.9 0.0 1.8e-40 138.5 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EGD99000.1 - 7.6e-28 97.7 0.0 9.1e-28 97.4 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase DUF1776 PF08643.10 EGD99000.1 - 0.00019 20.9 0.0 0.0016 17.9 0.0 1.9 1 1 0 1 1 1 1 Fungal family of unknown function (DUF1776) NAD_binding_10 PF13460.6 EGD99000.1 - 0.025 14.5 0.0 0.037 13.9 0.0 1.3 1 0 0 1 1 1 0 NAD(P)H-binding ADH_zinc_N PF00107.26 EGD99000.1 - 0.089 12.8 0.2 0.25 11.3 0.1 1.7 1 1 1 2 2 2 0 Zinc-binding dehydrogenase Beta-lactamase PF00144.24 EGD99001.1 - 3.5e-43 148.1 0.0 4.2e-43 147.8 0.0 1.1 1 0 0 1 1 1 1 Beta-lactamase Beta-lactamase2 PF13354.6 EGD99001.1 - 0.0013 18.4 0.0 1.7 8.2 0.0 2.3 2 0 0 2 2 2 2 Beta-lactamase enzyme family Peptidase_S11 PF00768.20 EGD99001.1 - 0.1 12.0 0.0 0.19 11.2 0.0 1.4 1 0 0 1 1 1 0 D-alanyl-D-alanine carboxypeptidase Peptidase_S8 PF00082.22 EGD99002.1 - 1.9e-24 86.5 14.1 3.3e-24 85.7 13.8 1.3 1 1 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 EGD99002.1 - 7.5e-20 71.4 0.0 1.3e-19 70.7 0.0 1.4 1 0 0 1 1 1 1 Peptidase inhibitor I9 SLAC1 PF03595.17 EGD99005.1 - 5.1e-84 282.3 52.8 5.9e-84 282.1 52.8 1.0 1 0 0 1 1 1 1 Voltage-dependent anion channel TraP PF07296.11 EGD99005.1 - 0.48 9.6 2.1 0.52 9.5 0.3 1.8 2 0 0 2 2 2 0 TraP protein CAAD PF14159.6 EGD99005.1 - 1.8 8.5 6.6 0.28 11.0 0.3 2.8 3 0 0 3 3 3 0 CAAD domains of cyanobacterial aminoacyl-tRNA synthetase ABC1 PF03109.16 EGD99006.1 - 8.3e-21 74.4 0.0 2.9e-18 66.2 0.0 2.5 1 1 0 1 1 1 1 ABC1 family RIO1 PF01163.22 EGD99006.1 - 0.042 13.4 0.0 0.09 12.4 0.0 1.5 1 0 0 1 1 1 0 RIO1 family Raf1_HTH PF18579.1 EGD99006.1 - 0.18 11.6 0.0 0.4 10.4 0.0 1.6 1 0 0 1 1 1 0 Rubisco accumulation factor 1 helix turn helix domain HA2 PF04408.23 EGD99007.1 - 2.2e-14 53.6 0.0 6.9e-13 48.8 0.0 2.6 2 0 0 2 2 2 1 Helicase associated domain (HA2) Helicase_C PF00271.31 EGD99007.1 - 3.9e-07 30.4 0.0 1.1e-06 28.9 0.0 1.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain AAA_19 PF13245.6 EGD99007.1 - 0.0039 17.5 0.1 0.0095 16.3 0.1 1.7 1 0 0 1 1 1 1 AAA domain DEAD PF00270.29 EGD99007.1 - 0.014 15.2 0.1 0.026 14.3 0.1 1.4 1 0 0 1 1 1 0 DEAD/DEAH box helicase AAA_22 PF13401.6 EGD99007.1 - 0.02 15.2 0.0 0.089 13.1 0.0 2.1 1 1 1 2 2 2 0 AAA domain PhoH PF02562.16 EGD99007.1 - 0.15 11.5 0.1 0.26 10.7 0.1 1.3 1 0 0 1 1 1 0 PhoH-like protein SSB PF00436.25 EGD99008.1 - 5.9e-14 52.0 0.0 7.9e-14 51.6 0.0 1.2 1 0 0 1 1 1 1 Single-strand binding protein family EFG_II PF14492.6 EGD99008.1 - 0.19 11.8 0.0 0.29 11.3 0.0 1.3 1 0 0 1 1 1 0 Elongation Factor G, domain II STE3 PF02076.15 EGD99009.1 - 7.4e-91 304.3 16.8 9.1e-91 304.0 16.8 1.1 1 0 0 1 1 1 1 Pheromone A receptor DUF4131 PF13567.6 EGD99009.1 - 0.45 10.2 3.6 0.34 10.5 0.6 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4131) FeoB_associated PF12669.7 EGD99009.1 - 0.59 10.6 0.1 0.59 10.6 0.1 2.6 3 0 0 3 3 3 0 FeoB-associated Cys-rich membrane protein Pex24p PF06398.11 EGD99009.1 - 3.5 6.5 9.2 0.17 10.8 3.7 1.6 2 0 0 2 2 2 0 Integral peroxisomal membrane peroxin Fib_alpha PF08702.10 EGD99010.1 - 0.45 10.7 2.6 0.86 9.8 2.6 1.5 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family Exo_endo_phos PF03372.23 EGD99011.1 - 2.8e-06 27.0 0.0 5e-06 26.2 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family RhoGAP PF00620.27 EGD99011.1 - 0.14 12.0 0.1 0.31 10.9 0.1 1.5 1 0 0 1 1 1 0 RhoGAP domain DUF4680 PF15730.5 EGD99011.1 - 0.5 10.7 1.8 1.2 9.5 1.8 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4680) DCP1 PF06058.13 EGD99012.1 - 1.7e-28 98.9 0.0 2.6e-28 98.3 0.0 1.2 1 0 0 1 1 1 1 Dcp1-like decapping family DUF1299 PF06975.11 EGD99012.1 - 0.0093 16.0 0.5 0.018 15.1 0.5 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1299) LIDHydrolase PF10230.9 EGD99013.1 - 1.6e-71 241.0 0.0 1.9e-71 240.7 0.0 1.0 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase Hydrolase_4 PF12146.8 EGD99013.1 - 4.2e-05 22.9 0.1 0.0013 18.0 0.0 2.3 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EGD99013.1 - 0.016 15.9 0.0 0.02 15.5 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family Thioesterase PF00975.20 EGD99013.1 - 0.019 15.1 0.0 0.041 14.0 0.0 1.5 1 0 0 1 1 1 0 Thioesterase domain Abhydrolase_3 PF07859.13 EGD99013.1 - 0.025 14.5 0.0 0.071 13.0 0.0 1.6 1 1 0 1 1 1 0 alpha/beta hydrolase fold Lipase_3 PF01764.25 EGD99013.1 - 0.091 12.6 0.0 0.36 10.7 0.0 1.9 2 0 0 2 2 2 0 Lipase (class 3) Abhydrolase_2 PF02230.16 EGD99013.1 - 0.12 12.1 0.0 0.2 11.5 0.0 1.2 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase DUF3530 PF12048.8 EGD99013.1 - 0.16 11.3 0.1 0.25 10.7 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3530) SMK-1 PF04802.15 EGD99014.1 - 1.4e-76 256.7 0.3 2.6e-76 255.7 0.3 1.5 1 0 0 1 1 1 1 Component of IIS longevity pathway SMK-1 DUF572 PF04502.13 EGD99014.1 - 0.047 13.3 14.7 0.08 12.6 14.7 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF572) Tub_N PF16322.5 EGD99015.1 - 0.043 14.2 28.6 0.058 13.8 28.6 1.2 1 0 0 1 1 1 0 Tubby N-terminal Nop14 PF04147.12 EGD99015.1 - 0.081 11.1 28.4 0.092 10.9 28.4 1.1 1 0 0 1 1 1 0 Nop14-like family BUD22 PF09073.10 EGD99015.1 - 0.3 10.4 28.2 0.35 10.1 28.2 1.1 1 0 0 1 1 1 0 BUD22 Mpp10 PF04006.12 EGD99015.1 - 1.4 7.3 34.2 1.7 7.0 34.2 1.0 1 0 0 1 1 1 0 Mpp10 protein DUF4604 PF15377.6 EGD99015.1 - 3.3 8.1 24.0 4.4 7.7 24.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) SDA1 PF05285.12 EGD99015.1 - 6.4 6.1 34.3 7.9 5.8 34.3 1.1 1 0 0 1 1 1 0 SDA1 Presenilin PF01080.17 EGD99015.1 - 6.6 5.4 15.4 7.4 5.2 15.4 1.0 1 0 0 1 1 1 0 Presenilin Na_trans_assoc PF06512.13 EGD99015.1 - 9.6 6.4 23.1 11 6.3 23.1 1.1 1 0 0 1 1 1 0 Sodium ion transport-associated SLC35F PF06027.12 EGD99016.1 - 2.2e-98 329.5 22.2 2.6e-98 329.2 22.2 1.0 1 0 0 1 1 1 1 Solute carrier family 35 CRT-like PF08627.10 EGD99016.1 - 2.6e-10 39.8 0.8 4e-10 39.2 0.8 1.4 1 0 0 1 1 1 1 CRT-like, chloroquine-resistance transporter-like EamA PF00892.20 EGD99016.1 - 3.7e-10 40.1 38.2 1.3e-05 25.3 15.8 2.1 2 0 0 2 2 2 2 EamA-like transporter family FUSC-like PF12805.7 EGD99016.1 - 4 6.4 11.0 0.026 13.6 1.2 2.3 3 1 0 3 3 3 0 FUSC-like inner membrane protein yccS COQ7 PF03232.13 EGD99018.1 - 0.004 16.9 0.2 0.0055 16.5 0.2 1.1 1 0 0 1 1 1 1 Ubiquinone biosynthesis protein COQ7 Utp21 PF04192.12 EGD99018.1 - 0.01 15.3 0.6 0.017 14.7 0.6 1.2 1 0 0 1 1 1 0 Utp21 specific WD40 associated putative domain Peptidase_S49_N PF08496.10 EGD99018.1 - 3.2 7.8 8.0 5.1 7.1 8.0 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Rib_recp_KP_reg PF05104.12 EGD99018.1 - 6.1 7.9 13.5 8.8 7.4 13.5 1.2 1 0 0 1 1 1 0 Ribosome receptor lysine/proline rich region Tho2 PF11262.8 EGD99018.1 - 7.6 5.6 10.5 10 5.2 10.5 1.1 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 PAP_assoc PF03828.19 EGD99020.1 - 3.7e-17 62.3 0.1 9.1e-17 61.0 0.1 1.7 1 0 0 1 1 1 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.23 EGD99020.1 - 2.1e-06 27.9 0.0 4.1e-06 27.0 0.0 1.5 1 0 0 1 1 1 1 Nucleotidyltransferase domain Polbeta PF18765.1 EGD99020.1 - 0.055 13.5 0.0 0.14 12.2 0.0 1.7 1 0 0 1 1 1 0 Polymerase beta, Nucleotidyltransferase SE PF08491.10 EGD99021.1 - 1.6e-93 312.8 0.0 1.9e-93 312.5 0.0 1.1 1 0 0 1 1 1 1 Squalene epoxidase FAD_binding_3 PF01494.19 EGD99021.1 - 5.3e-10 39.1 0.0 1e-08 34.8 0.0 2.1 2 0 0 2 2 2 1 FAD binding domain DAO PF01266.24 EGD99021.1 - 5.6e-09 36.0 0.4 7.2e-06 25.8 0.4 2.1 2 0 0 2 2 2 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EGD99021.1 - 3.2e-06 26.5 2.0 7.5e-05 22.0 2.4 2.0 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_2 PF07992.14 EGD99021.1 - 0.00015 21.1 0.1 0.00034 20.0 0.1 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EGD99021.1 - 0.00034 20.8 0.8 0.00072 19.7 0.8 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.7 EGD99021.1 - 0.00038 19.9 1.6 0.00051 19.5 1.6 1.3 1 1 0 1 1 1 1 FAD dependent oxidoreductase GIDA PF01134.22 EGD99021.1 - 0.00042 19.5 0.2 0.0011 18.2 0.1 1.6 2 0 0 2 2 2 1 Glucose inhibited division protein A Lycopene_cycl PF05834.12 EGD99021.1 - 0.00046 19.4 0.6 0.00088 18.4 0.6 1.4 1 0 0 1 1 1 1 Lycopene cyclase protein HI0933_like PF03486.14 EGD99021.1 - 0.0013 17.5 0.3 0.0033 16.2 0.3 1.6 1 0 0 1 1 1 1 HI0933-like protein Thi4 PF01946.17 EGD99021.1 - 0.0018 17.5 0.0 0.0032 16.8 0.0 1.3 1 0 0 1 1 1 1 Thi4 family Pyr_redox PF00070.27 EGD99021.1 - 0.0021 18.6 0.1 0.021 15.4 0.2 2.4 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Shikimate_DH PF01488.20 EGD99021.1 - 0.0092 16.0 0.0 0.015 15.4 0.0 1.3 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase ApbA PF02558.16 EGD99021.1 - 0.012 15.2 0.4 0.04 13.6 0.4 1.8 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA Trp_halogenase PF04820.14 EGD99021.1 - 0.024 13.5 0.2 0.39 9.5 0.2 2.0 2 0 0 2 2 2 0 Tryptophan halogenase Pyr_redox_3 PF13738.6 EGD99021.1 - 0.13 11.4 0.0 0.25 10.5 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_Gly3P_dh_N PF01210.23 EGD99021.1 - 0.14 12.1 0.0 0.24 11.4 0.0 1.3 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus AlaDh_PNT_C PF01262.21 EGD99021.1 - 0.18 11.0 0.1 0.31 10.3 0.1 1.2 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain PPR PF01535.20 EGD99022.1 - 1.3e-06 28.2 0.4 0.07 13.4 0.0 5.3 4 0 0 4 4 4 2 PPR repeat PPR_2 PF13041.6 EGD99022.1 - 0.0069 16.6 0.0 1.9 8.7 0.0 4.0 4 0 0 4 4 4 1 PPR repeat family PPR_1 PF12854.7 EGD99022.1 - 0.011 15.5 0.0 10 6.0 0.0 3.4 3 0 0 3 3 3 0 PPR repeat TPR_14 PF13428.6 EGD99022.1 - 0.011 16.4 0.5 2.1 9.4 0.0 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.6 EGD99022.1 - 0.022 15.3 0.1 11 6.6 0.0 3.9 3 1 0 3 3 3 0 Tetratricopeptide repeat MFS_1 PF07690.16 EGD99023.1 - 6.5e-28 97.7 17.6 6.5e-20 71.4 8.9 2.2 2 0 0 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 EGD99023.1 - 0.0012 17.2 8.5 0.37 9.0 3.8 2.9 2 1 0 2 2 2 2 Organic Anion Transporter Polypeptide (OATP) family DUF2269 PF10027.9 EGD99023.1 - 0.028 14.5 0.3 0.028 14.5 0.3 2.8 3 0 0 3 3 3 0 Predicted integral membrane protein (DUF2269) FA_desaturase PF00487.24 EGD99023.1 - 2.3 8.0 9.7 0.49 10.2 2.2 3.1 3 1 1 4 4 4 0 Fatty acid desaturase Ferrochelatase PF00762.19 EGD99024.1 - 8e-98 327.4 0.0 9.4e-98 327.2 0.0 1.0 1 0 0 1 1 1 1 Ferrochelatase Ku PF02735.16 EGD99025.1 - 6.3e-45 153.4 0.0 3e-44 151.2 0.0 2.0 2 0 0 2 2 2 1 Ku70/Ku80 beta-barrel domain Ku_N PF03731.15 EGD99025.1 - 8.2e-32 110.7 0.0 1.3e-31 110.1 0.0 1.2 1 0 0 1 1 1 1 Ku70/Ku80 N-terminal alpha/beta domain Ku_C PF03730.14 EGD99025.1 - 2.5e-28 98.6 3.4 6.7e-28 97.2 3.4 1.8 1 0 0 1 1 1 1 Ku70/Ku80 C-terminal arm SAP PF02037.27 EGD99025.1 - 1.8e-13 49.9 0.0 3.6e-13 48.9 0.0 1.5 1 0 0 1 1 1 1 SAP domain HeH PF12949.7 EGD99025.1 - 0.00078 19.1 0.2 0.00078 19.1 0.2 1.8 2 0 0 2 2 2 1 HeH/LEM domain Adap_comp_sub PF00928.21 EGD99026.1 - 8.6e-83 277.7 0.0 1.1e-82 277.4 0.0 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 EGD99026.1 - 5.2e-05 23.2 0.3 8.8e-05 22.5 0.3 1.3 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Erf4 PF10256.9 EGD99027.1 - 5e-41 139.5 0.0 7.5e-41 138.9 0.0 1.3 1 0 0 1 1 1 1 Golgin subfamily A member 7/ERF4 family Ring_hydroxyl_A PF00848.19 EGD99027.1 - 0.11 12.5 0.4 0.26 11.2 0.4 1.6 1 0 0 1 1 1 0 Ring hydroxylating alpha subunit (catalytic domain) Lipase_3 PF01764.25 EGD99028.1 - 0.00021 21.2 0.0 0.00031 20.6 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_8 PF06259.12 EGD99028.1 - 0.02 14.6 0.0 0.035 13.8 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase Abhydrolase_6 PF12697.7 EGD99028.1 - 0.051 14.2 0.0 0.072 13.7 0.0 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase family DUF2974 PF11187.8 EGD99028.1 - 0.071 12.7 0.0 0.11 12.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) MBDa PF16564.5 EGD99028.1 - 0.078 13.2 0.0 0.15 12.3 0.0 1.4 1 0 0 1 1 1 0 p55-binding region of Methyl-CpG-binding domain proteins MBD DUF900 PF05990.12 EGD99028.1 - 0.14 11.7 0.0 0.23 10.9 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) zf-C2H2_4 PF13894.6 EGD99029.1 - 1.7e-14 53.2 8.3 0.05 14.5 0.1 4.7 4 0 0 4 4 4 4 C2H2-type zinc finger zf-C2H2 PF00096.26 EGD99029.1 - 2.8e-13 49.5 14.3 0.0038 17.6 0.9 4.8 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 EGD99029.1 - 3.3e-13 49.6 12.9 6.2e-07 29.5 0.4 4.1 4 0 0 4 4 4 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EGD99029.1 - 7.3e-13 48.4 15.8 1.8e-07 31.3 0.9 4.2 4 0 0 4 4 4 2 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 EGD99029.1 - 1.7e-09 37.4 7.5 0.0057 16.6 0.2 3.5 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_2 PF12756.7 EGD99029.1 - 2e-09 37.7 14.2 0.0076 16.6 0.5 4.1 1 1 3 4 4 4 3 C2H2 type zinc-finger (2 copies) zf-H2C2_2 PF13465.6 EGD99029.1 - 3.7e-06 27.1 16.8 0.25 11.9 0.0 4.8 4 1 0 4 4 4 2 Zinc-finger double domain Peptidase_M4 PF01447.18 EGD99029.1 - 0.0034 17.9 0.3 0.0049 17.4 0.3 1.2 1 0 0 1 1 1 1 Thermolysin metallopeptidase, catalytic domain zf-DBF PF07535.12 EGD99029.1 - 0.011 15.8 8.0 0.39 10.9 0.3 3.5 2 1 1 3 3 3 0 DBF zinc finger zf-C2H2_11 PF16622.5 EGD99029.1 - 0.012 15.4 2.6 4.6 7.1 0.0 3.7 4 0 0 4 4 4 0 zinc-finger C2H2-type HypA PF01155.19 EGD99029.1 - 0.026 14.6 5.9 0.88 9.6 0.9 2.4 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf_ZIC PF18366.1 EGD99029.1 - 0.03 14.4 0.7 11 6.2 0.1 2.7 2 0 0 2 2 2 0 Zic proteins zinc finger domain zf-Di19 PF05605.12 EGD99029.1 - 0.078 13.3 0.2 0.078 13.3 0.2 3.3 2 1 1 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding zinc_ribbon_15 PF17032.5 EGD99029.1 - 0.09 13.5 10.2 2.6 8.9 10.6 2.7 1 1 2 3 3 3 0 zinc-ribbon family Zn-ribbon_8 PF09723.10 EGD99029.1 - 0.092 12.9 0.8 0.092 12.9 0.8 4.1 4 1 1 5 5 4 0 Zinc ribbon domain zf-C2H2_9 PF16293.5 EGD99029.1 - 0.18 11.7 5.8 5.3 7.0 0.1 3.9 4 0 0 4 4 4 0 C2H2 type zinc-finger (1 copy) DUF530 PF04409.12 EGD99029.1 - 0.26 9.6 0.9 0.38 9.1 0.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF530) HET-S PF17108.5 EGD99029.1 - 0.35 10.6 2.4 0.67 9.8 2.4 1.5 1 0 0 1 1 1 0 N-terminal small S protein of HET, non-prionic Zn_Tnp_IS1 PF03811.13 EGD99029.1 - 0.47 10.2 7.0 3.2 7.6 4.5 2.9 2 0 0 2 2 2 0 InsA N-terminal domain DUF3449 PF11931.8 EGD99029.1 - 0.99 9.2 6.7 4 7.2 1.3 2.6 2 1 1 3 3 3 0 Domain of unknown function (DUF3449) zf-C2H2_8 PF15909.5 EGD99029.1 - 1.2 9.4 8.8 11 6.4 0.2 2.8 1 1 2 3 3 3 0 C2H2-type zinc ribbon zf-AN1 PF01428.16 EGD99029.1 - 1.2 9.3 15.5 5.1 7.4 0.4 4.7 5 0 0 5 5 5 0 AN1-like Zinc finger zinc-ribbons_6 PF07191.12 EGD99029.1 - 1.7 8.6 13.4 38 4.3 0.3 3.8 1 1 1 2 2 2 0 zinc-ribbons zf_UBZ PF18439.1 EGD99029.1 - 8.8 6.0 8.4 15 5.3 0.2 3.6 4 0 0 4 4 4 0 Ubiquitin-Binding Zinc Finger Cyto_heme_lyase PF01265.17 EGD99030.1 - 1.4e-124 415.4 0.9 1.6e-124 415.3 0.9 1.0 1 0 0 1 1 1 1 Cytochrome c/c1 heme lyase Paramyxo_NS_C PF02725.14 EGD99030.1 - 0.13 12.4 0.3 0.2 11.7 0.3 1.3 1 0 0 1 1 1 0 Non-structural protein C Fungal_trans_2 PF11951.8 EGD99031.1 - 6.1e-07 28.6 0.0 1.4e-06 27.4 0.0 1.6 1 1 0 1 1 1 1 Fungal specific transcription factor domain SR-25 PF10500.9 EGD99031.1 - 5.4 6.6 23.4 0.1 12.2 14.8 2.0 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein UQ_con PF00179.26 EGD99032.1 - 7.1e-19 67.8 0.1 1.1e-18 67.3 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Bac_surface_Ag PF01103.23 EGD99033.1 - 1.3e-43 149.8 0.1 1.6e-43 149.5 0.1 1.1 1 0 0 1 1 1 1 Surface antigen Yip1 PF04893.17 EGD99034.1 - 1.2e-06 28.3 13.8 0.00013 21.7 8.3 2.3 2 0 0 2 2 2 2 Yip1 domain TFIIA PF03153.13 EGD99035.1 - 2.1 8.3 19.1 2.5 8.0 19.1 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit UFD1 PF03152.14 EGD99037.1 - 5.1e-29 101.0 0.0 7.1e-27 94.0 0.0 2.7 1 1 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 AZUL PF16558.5 EGD99037.1 - 1.1e-06 28.8 0.1 4.2e-06 26.9 0.1 2.0 1 0 0 1 1 1 1 Amino-terminal Zinc-binding domain of ubiquitin ligase E3A PEX-1N PF09262.11 EGD99037.1 - 0.13 12.7 0.2 0.38 11.2 0.0 1.9 2 0 0 2 2 2 0 Peroxisome biogenesis factor 1, N-terminal DPPIV_N PF00930.21 EGD99038.1 - 5.2e-112 374.1 6.2 8.7e-112 373.4 6.2 1.4 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.21 EGD99038.1 - 3.3e-39 134.6 2.8 5.8e-39 133.8 2.8 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_6 PF12697.7 EGD99038.1 - 0.022 15.4 0.0 0.052 14.1 0.0 1.7 1 0 0 1 1 1 0 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EGD99038.1 - 0.089 12.0 0.0 0.17 11.1 0.0 1.4 1 0 0 1 1 1 0 Serine aminopeptidase, S33 2OG-FeII_Oxy PF03171.20 EGD99038.1 - 0.098 13.2 0.0 0.8 10.2 0.0 2.5 2 0 0 2 2 2 0 2OG-Fe(II) oxygenase superfamily Peptidase_S8 PF00082.22 EGD99039.1 - 2.6e-24 86.0 14.9 5.3e-24 85.0 14.9 1.4 1 1 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 EGD99039.1 - 3.7e-14 53.1 0.1 6.8e-14 52.3 0.1 1.5 1 0 0 1 1 1 1 Peptidase inhibitor I9 MAPEG PF01124.18 EGD99040.1 - 1.5e-10 41.1 3.0 1.9e-10 40.7 3.0 1.3 1 1 0 1 1 1 1 MAPEG family MARVEL PF01284.23 EGD99041.1 - 4e-06 26.9 11.8 7.3e-06 26.1 11.9 1.4 1 1 0 1 1 1 1 Membrane-associating domain DUF1129 PF06570.11 EGD99041.1 - 1.6 8.2 4.4 3 7.3 4.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1129) ABC2_membrane_5 PF13346.6 EGD99041.1 - 2.2 7.8 14.3 0.18 11.3 7.9 2.1 1 1 0 2 2 2 0 ABC-2 family transporter protein DUF4131 PF13567.6 EGD99041.1 - 2.9 7.5 6.1 5.5 6.6 1.7 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) RNB PF00773.19 EGD99042.1 - 2e-53 181.9 0.0 2e-51 175.2 0.0 2.2 1 1 0 1 1 1 1 RNB domain Tom6 PF17112.5 EGD99043.1 - 0.00082 18.8 0.0 0.001 18.6 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial import receptor subunit Tom6, fungal CTNNBL PF08216.11 EGD99044.1 - 1e-38 131.7 0.5 4.4e-38 129.6 0.2 2.3 2 0 0 2 2 2 1 Catenin-beta-like, Arm-motif containing nuclear PHTB1_C PF14728.6 EGD99044.1 - 0.013 14.6 0.3 0.024 13.7 0.3 1.3 1 0 0 1 1 1 0 PTHB1 C-terminus HEAT_2 PF13646.6 EGD99044.1 - 0.048 14.1 0.0 0.37 11.2 0.0 2.6 1 1 1 2 2 2 0 HEAT repeats RNA_pol_Rpb2_6 PF00562.28 EGD99045.1 - 1.9e-123 412.4 0.7 2.5e-123 412.0 0.1 1.5 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 EGD99045.1 - 9.4e-60 201.6 0.0 2.6e-59 200.2 0.0 1.8 1 1 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_2 PF04561.14 EGD99045.1 - 2.9e-47 160.8 0.0 5.1e-47 160.0 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_7 PF04560.20 EGD99045.1 - 2.5e-33 114.4 0.0 5.3e-33 113.3 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_3 PF04565.16 EGD99045.1 - 1.2e-25 89.4 0.1 3.2e-25 88.1 0.1 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_4 PF04566.13 EGD99045.1 - 1.3e-24 86.2 0.4 3.7e-24 84.8 0.4 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_5 PF04567.17 EGD99045.1 - 7.1e-23 80.9 2.0 1.2e-22 80.2 0.4 2.4 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 5 MRNIP PF15749.5 EGD99045.1 - 2 9.2 4.4 0.37 11.5 0.1 2.0 2 0 0 2 2 2 0 MRN-interacting protein AMPK1_CBM PF16561.5 EGD99047.1 - 3.4e-05 24.0 0.0 5.7e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase DUF951 PF06107.11 EGD99047.1 - 0.11 12.4 0.7 0.2 11.6 0.7 1.3 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF951) Nucleopor_Nup85 PF07575.13 EGD99048.1 - 1.5e-20 73.3 0.9 1.8e-16 59.9 0.0 2.8 3 0 0 3 3 3 2 Nup85 Nucleoporin ADH_zinc_N PF00107.26 EGD99050.1 - 3.5e-14 52.9 0.0 5.3e-14 52.3 0.0 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EGD99050.1 - 2.8e-07 31.6 0.0 4.5e-07 31.0 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EGD99050.1 - 7.2e-07 29.1 0.0 1.3e-06 28.2 0.0 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain 2-Hacid_dh_C PF02826.19 EGD99050.1 - 0.0029 17.0 0.0 0.0044 16.4 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain GFO_IDH_MocA PF01408.22 EGD99050.1 - 0.13 13.1 0.0 0.32 11.8 0.0 1.7 2 0 0 2 2 2 0 Oxidoreductase family, NAD-binding Rossmann fold TPR_19 PF14559.6 EGD99051.1 - 1.1e-15 57.9 17.2 0.00089 19.7 0.1 7.5 7 1 1 8 8 7 5 Tetratricopeptide repeat TPR_11 PF13414.6 EGD99051.1 - 1.4e-13 50.3 6.7 0.00048 19.7 0.1 6.1 5 1 1 6 6 6 3 TPR repeat TPR_17 PF13431.6 EGD99051.1 - 8.7e-11 41.4 13.9 0.0018 18.5 0.1 7.0 9 0 0 9 9 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 EGD99051.1 - 3.1e-10 39.4 25.5 0.013 15.5 0.5 9.9 10 0 0 10 10 9 2 Tetratricopeptide repeat TPR_14 PF13428.6 EGD99051.1 - 3.9e-10 39.7 13.3 0.47 11.4 0.0 8.9 7 2 3 10 10 8 2 Tetratricopeptide repeat TPR_16 PF13432.6 EGD99051.1 - 1.1e-08 35.6 7.1 0.00062 20.4 0.4 5.2 3 2 2 5 5 5 2 Tetratricopeptide repeat TPR_1 PF00515.28 EGD99051.1 - 2.2e-07 30.4 26.6 0.12 12.2 0.6 8.6 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_12 PF13424.6 EGD99051.1 - 2.5e-06 27.7 22.4 0.13 12.6 0.3 8.2 8 1 0 8 8 8 3 Tetratricopeptide repeat TPR_8 PF13181.6 EGD99051.1 - 2.3e-05 24.3 24.4 0.29 11.5 0.4 8.3 10 0 0 10 10 7 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EGD99051.1 - 5.3e-05 23.4 12.4 0.021 15.1 0.1 5.8 6 0 0 6 6 6 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.6 EGD99051.1 - 0.00026 21.1 7.3 0.011 15.8 0.0 4.8 4 1 2 6 6 4 2 Tetratricopeptide repeat TPR_7 PF13176.6 EGD99051.1 - 0.00026 20.8 11.7 7.3 6.9 0.0 6.8 7 0 0 7 7 6 1 Tetratricopeptide repeat TPR_15 PF13429.6 EGD99051.1 - 0.0072 15.6 1.2 20 4.3 0.0 3.9 3 0 0 3 3 3 0 Tetratricopeptide repeat BTAD PF03704.17 EGD99051.1 - 0.0087 16.5 1.4 0.083 13.3 0.2 2.6 1 1 1 2 2 2 1 Bacterial transcriptional activator domain TPR_MalT PF17874.1 EGD99051.1 - 0.028 13.8 2.8 1.6 8.0 0.2 3.9 3 1 1 4 4 4 0 MalT-like TPR region TPR_20 PF14561.6 EGD99051.1 - 0.029 14.7 3.1 2.6 8.4 0.1 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat ChAPs PF09295.10 EGD99051.1 - 0.076 12.0 0.0 0.14 11.1 0.0 1.3 1 0 0 1 1 1 0 ChAPs (Chs5p-Arf1p-binding proteins) RPN7 PF10602.9 EGD99051.1 - 0.13 11.9 1.3 16 5.1 0.4 3.5 3 1 1 4 4 4 0 26S proteasome subunit RPN7 DUF2989 PF11207.8 EGD99051.1 - 0.25 11.1 2.6 12 5.6 0.0 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF2989) TPR_10 PF13374.6 EGD99051.1 - 1.6 8.7 14.3 0.24 11.3 0.5 5.7 8 0 0 8 8 7 0 Tetratricopeptide repeat TPR_4 PF07721.14 EGD99051.1 - 5.5 7.9 13.3 0.65 10.8 0.2 4.8 6 0 0 6 6 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 EGD99051.1 - 8.9 7.2 15.1 11 6.9 0.2 6.1 6 0 0 6 6 4 0 Tetratricopeptide repeat DUF3336 PF11815.8 EGD99052.1 - 1.4e-47 160.9 1.5 2.3e-47 160.2 1.5 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3336) Patatin PF01734.22 EGD99052.1 - 1.4e-18 67.8 0.5 6.2e-18 65.7 0.1 2.3 2 1 0 2 2 2 1 Patatin-like phospholipase FA_desaturase PF00487.24 EGD99052.1 - 0.013 15.4 0.2 0.038 13.8 0.0 1.9 2 0 0 2 2 2 0 Fatty acid desaturase Zip PF02535.22 EGD99055.1 - 0.0027 17.0 1.4 0.0027 17.0 1.4 2.9 2 1 0 2 2 2 1 ZIP Zinc transporter LRR_4 PF12799.7 EGD99055.1 - 0.005 17.2 0.0 0.078 13.4 0.0 2.6 2 1 0 2 2 2 1 Leucine Rich repeats (2 copies) SART-1 PF03343.13 EGD99055.1 - 0.024 13.2 4.2 0.053 12.1 1.5 2.1 2 0 0 2 2 2 0 SART-1 family CHDCT2 PF08074.11 EGD99055.1 - 1 9.5 3.8 2.6 8.2 3.8 1.6 1 0 0 1 1 1 0 CHDCT2 (NUC038) domain EPL1 PF10513.9 EGD99055.1 - 9.6 6.6 10.7 3.2 8.1 1.5 3.3 3 0 0 3 3 3 0 Enhancer of polycomb-like Metallophos PF00149.28 EGD99057.1 - 2.4e-40 139.2 0.1 3.1e-40 138.8 0.1 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 EGD99057.1 - 1.2e-22 80.1 2.6 1.5e-22 79.8 1.7 1.7 2 0 0 2 2 2 1 Serine-threonine protein phosphatase N-terminal domain Arf PF00025.21 EGD99058.1 - 6.5e-64 214.6 0.0 7.3e-64 214.4 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 EGD99058.1 - 2.6e-09 36.7 0.0 1.1e-05 24.7 0.0 2.3 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.10 EGD99058.1 - 2.5e-08 33.6 0.0 3.2e-08 33.2 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 EGD99058.1 - 2.7e-06 27.4 0.0 3.6e-06 27.0 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Roc PF08477.13 EGD99058.1 - 6.3e-06 26.4 0.0 1.4e-05 25.2 0.0 1.6 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EGD99058.1 - 0.00022 20.8 0.0 0.00031 20.4 0.0 1.2 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 EGD99058.1 - 0.0025 17.2 0.0 0.0029 17.0 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region mRNA_decap_C PF16741.5 EGD99058.1 - 0.094 12.0 0.2 0.65 9.3 0.1 2.1 2 0 0 2 2 2 0 mRNA-decapping enzyme C-terminus DUF3435 PF11917.8 EGD99060.1 - 9.1e-66 222.5 2.2 3.2e-39 135.0 0.1 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF3435) DUF2457 PF10446.9 EGD99062.1 - 1.7e-149 499.0 38.5 1.7e-149 499.0 38.5 2.3 2 1 0 2 2 2 1 Protein of unknown function (DUF2457) RPOL_N PF14700.6 EGD99062.1 - 0.031 13.7 2.5 0.076 12.4 2.5 1.5 1 0 0 1 1 1 0 DNA-directed RNA polymerase N-terminal CDC45 PF02724.14 EGD99062.1 - 1.8 6.8 35.6 1.6 6.9 27.1 2.3 2 0 0 2 2 2 0 CDC45-like protein CH PF00307.31 EGD99065.1 - 9.8e-08 32.2 0.0 0.001 19.3 0.0 2.4 2 0 0 2 2 2 2 Calponin homology (CH) domain IQ PF00612.27 EGD99065.1 - 0.0097 15.6 1.4 0.03 14.1 1.4 1.9 1 0 0 1 1 1 1 IQ calmodulin-binding motif Ank_2 PF12796.7 EGD99066.1 - 4.3e-26 91.3 9.1 2.1e-09 37.8 0.2 4.8 2 1 4 6 6 6 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EGD99066.1 - 1.6e-22 79.6 1.9 6.1e-05 23.5 0.1 6.6 5 2 1 6 6 6 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EGD99066.1 - 1.6e-19 67.9 0.2 0.012 16.1 0.0 8.2 8 1 0 8 8 8 4 Ankyrin repeat Ank_5 PF13857.6 EGD99066.1 - 3.2e-19 68.7 6.5 2.5e-07 30.9 0.4 5.3 4 1 1 5 5 5 4 Ankyrin repeats (many copies) Ank PF00023.30 EGD99066.1 - 1.2e-14 53.9 2.8 0.02 15.3 0.0 7.1 7 1 0 7 7 7 3 Ankyrin repeat Vezatin PF12632.7 EGD99067.1 - 3.1e-70 236.7 0.2 3.1e-70 236.7 0.2 1.7 2 0 0 2 2 2 1 Mysoin-binding motif of peroxisomes MatE PF01554.18 EGD99067.1 - 0.0029 17.3 0.1 1.5 8.5 0.2 2.2 1 1 1 2 2 2 2 MatE TetR_C_9 PF14514.6 EGD99067.1 - 0.036 14.2 0.2 0.1 12.7 0.2 1.7 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain DUF2157 PF09925.9 EGD99067.1 - 0.043 13.6 1.6 0.082 12.7 1.6 1.4 1 0 0 1 1 1 0 Predicted membrane protein (DUF2157) ALMS_motif PF15309.6 EGD99067.1 - 0.11 13.0 3.2 3.6 8.0 1.1 2.6 2 0 0 2 2 2 0 ALMS motif Polysacc_synt_C PF14667.6 EGD99067.1 - 0.13 12.3 5.8 0.2 11.7 5.8 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis C-terminal domain PCNA_C PF02747.15 EGD99068.1 - 6.7e-52 175.0 0.1 5.8e-51 172.0 0.0 2.0 2 0 0 2 2 2 1 Proliferating cell nuclear antigen, C-terminal domain PCNA_N PF00705.18 EGD99068.1 - 4.2e-47 159.0 3.7 8.3e-47 158.1 3.7 1.4 1 0 0 1 1 1 1 Proliferating cell nuclear antigen, N-terminal domain Rad9 PF04139.13 EGD99068.1 - 5.1e-06 26.1 0.0 7e-06 25.7 0.0 1.1 1 0 0 1 1 1 1 Rad9 Rad1 PF02144.16 EGD99068.1 - 0.00023 20.3 0.3 0.00089 18.4 0.3 1.8 1 1 0 1 1 1 1 Repair protein Rad1/Rec1/Rad17 Hus1 PF04005.12 EGD99068.1 - 0.12 11.4 0.2 3 6.9 0.0 2.1 2 0 0 2 2 2 0 Hus1-like protein Fungal_trans_2 PF11951.8 EGD99069.1 - 3.6e-19 68.9 0.1 9.8e-15 54.2 1.0 2.5 2 0 0 2 2 2 2 Fungal specific transcription factor domain Zn_clus PF00172.18 EGD99069.1 - 4.5e-07 29.9 11.9 9.6e-07 28.8 11.9 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF3439 PF11921.8 EGD99069.1 - 0.07 13.1 4.4 0.19 11.7 4.4 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Asp_protease PF09668.10 EGD99070.1 - 2e-61 205.2 0.2 3.4e-61 204.5 0.2 1.4 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 EGD99070.1 - 1.4e-22 80.0 0.0 3.2e-22 78.9 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 EGD99070.1 - 7.3e-11 42.6 0.1 5e-10 39.9 0.0 2.2 2 0 0 2 2 2 1 Aspartyl protease ubiquitin PF00240.23 EGD99070.1 - 1.2e-10 41.0 0.0 1.9e-10 40.4 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family UBA PF00627.31 EGD99070.1 - 4.3e-07 29.7 0.0 9e-07 28.7 0.0 1.6 1 0 0 1 1 1 1 UBA/TS-N domain Rad60-SLD PF11976.8 EGD99070.1 - 0.0011 18.8 0.0 0.0026 17.6 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like UBA_4 PF14555.6 EGD99070.1 - 0.0037 17.1 0.1 0.0071 16.1 0.1 1.4 1 0 0 1 1 1 1 UBA-like domain RVP_2 PF08284.11 EGD99070.1 - 0.0044 16.8 0.4 0.014 15.2 0.1 1.9 2 1 0 2 2 2 1 Retroviral aspartyl protease UN_NPL4 PF11543.8 EGD99070.1 - 0.013 16.0 0.0 0.026 15.0 0.0 1.5 1 0 0 1 1 1 0 Nuclear pore localisation protein NPL4 RVP PF00077.20 EGD99070.1 - 0.048 14.0 0.0 0.11 12.8 0.0 1.7 1 0 0 1 1 1 0 Retroviral aspartyl protease Acetyltransf_10 PF13673.7 EGD99071.1 - 6.6e-13 48.7 0.0 9.7e-13 48.2 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EGD99071.1 - 8.8e-10 38.8 0.0 1.2e-09 38.4 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EGD99071.1 - 2.2e-07 31.2 0.0 4e-07 30.4 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EGD99071.1 - 0.00029 20.7 0.0 0.00052 19.9 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein MOZ_SAS PF01853.18 EGD99071.1 - 0.17 11.5 0.0 0.26 10.9 0.0 1.2 1 0 0 1 1 1 0 MOZ/SAS family Acetyltransf_CG PF14542.6 EGD99071.1 - 0.18 12.0 0.0 0.33 11.1 0.0 1.3 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase DUF2457 PF10446.9 EGD99071.1 - 0.35 10.0 7.2 0.47 9.5 7.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) PGA2 PF07543.12 EGD99071.1 - 0.56 10.2 2.0 1 9.4 2.0 1.3 1 0 0 1 1 1 0 Protein trafficking PGA2 DNA_pol_phi PF04931.13 EGD99071.1 - 0.76 7.8 3.9 0.97 7.5 3.9 1.1 1 0 0 1 1 1 0 DNA polymerase phi CENP-B_dimeris PF09026.10 EGD99071.1 - 1.5 9.3 10.2 3 8.3 10.2 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Cwf_Cwc_15 PF04889.12 EGD99071.1 - 7 6.3 6.7 10 5.8 6.7 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein NOG1_N PF17835.1 EGD99072.1 - 2e-47 161.1 1.1 4.2e-47 160.1 0.1 2.1 2 0 0 2 2 2 1 NOG1 N-terminal helical domain NOGCT PF08155.11 EGD99072.1 - 3.3e-29 100.6 1.5 7.9e-29 99.4 1.5 1.7 1 0 0 1 1 1 1 NOGCT (NUC087) domain NOG1 PF06858.14 EGD99072.1 - 3.2e-26 90.9 0.3 7.3e-26 89.7 0.3 1.7 1 0 0 1 1 1 1 Nucleolar GTP-binding protein 1 (NOG1) MMR_HSR1 PF01926.23 EGD99072.1 - 1.8e-15 57.0 0.0 4.5e-15 55.7 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EGD99072.1 - 8.3e-08 31.9 0.0 3.1e-07 30.0 0.0 1.9 1 1 0 1 1 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 EGD99072.1 - 0.00023 21.1 0.3 0.059 13.3 0.0 3.2 3 1 0 3 3 3 1 RsgA GTPase Dynamin_N PF00350.23 EGD99072.1 - 0.0056 16.8 0.0 1.7 8.7 0.0 2.8 1 1 1 2 2 2 1 Dynamin family AAA_16 PF13191.6 EGD99072.1 - 0.013 15.9 1.5 0.15 12.5 0.0 3.3 3 1 0 3 3 3 0 AAA ATPase domain E1_DerP2_DerF2 PF02221.15 EGD99073.1 - 5.6e-27 94.8 0.1 6.8e-27 94.5 0.1 1.1 1 0 0 1 1 1 1 ML domain TRP_N PF14558.6 EGD99073.1 - 0.00051 20.4 0.0 0.00099 19.5 0.0 1.5 1 1 0 1 1 1 1 ML-like domain Glyco_hydro_61 PF03443.14 EGD99073.1 - 0.015 15.3 0.0 0.025 14.5 0.0 1.4 1 1 0 1 1 1 0 Glycosyl hydrolase family 61 CopC PF04234.12 EGD99073.1 - 0.093 13.8 0.0 0.13 13.3 0.0 1.4 1 0 0 1 1 1 0 CopC domain Alph_Pro_TM PF09608.10 EGD99073.1 - 0.18 11.6 0.0 0.21 11.4 0.0 1.1 1 0 0 1 1 1 0 Putative transmembrane protein (Alph_Pro_TM) ATP-synt_F PF01990.17 EGD99074.1 - 2.1e-33 114.5 0.0 2.4e-33 114.3 0.0 1.0 1 0 0 1 1 1 1 ATP synthase (F/14-kDa) subunit DUF2418 PF10332.9 EGD99075.1 - 2.3e-35 121.0 0.2 5.3e-35 119.8 0.2 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF2418) MTHFR PF02219.17 EGD99077.1 - 7e-116 386.5 0.0 1e-115 386.0 0.0 1.2 1 0 0 1 1 1 1 Methylenetetrahydrofolate reductase DUF1804 PF08822.11 EGD99077.1 - 0.06 13.3 0.1 0.16 12.0 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1804) CAC1F_C PF16885.5 EGD99078.1 - 0.01 15.5 1.0 0.01 15.5 1.0 1.0 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term Pribosyltran PF00156.27 EGD99079.1 - 1.4e-13 50.7 0.2 2.3e-13 50.0 0.2 1.2 1 0 0 1 1 1 1 Phosphoribosyl transferase domain Aconitase PF00330.20 EGD99080.1 - 4.5e-165 550.1 0.0 5.7e-165 549.8 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 EGD99080.1 - 1.1e-40 139.0 0.0 1.9e-40 138.2 0.0 1.4 1 0 0 1 1 1 1 Aconitase C-terminal domain Glycos_transf_4 PF00953.21 EGD99081.1 - 8.8e-34 116.8 9.9 8.8e-34 116.8 9.9 2.0 2 1 0 2 2 2 1 Glycosyl transferase family 4 DUF2070 PF09843.9 EGD99081.1 - 8.9 4.5 11.6 6.4 4.9 10.0 1.6 1 1 0 1 1 1 0 Predicted membrane protein (DUF2070) WD40 PF00400.32 EGD99082.1 - 1.5e-10 41.5 7.7 0.0088 16.9 0.0 4.6 4 0 0 4 4 4 3 WD domain, G-beta repeat Myb_DNA-binding PF00249.31 EGD99084.1 - 6.4e-10 39.1 0.0 2e-09 37.5 0.0 1.8 1 0 0 1 1 1 1 Myb-like DNA-binding domain SWIRM PF04433.17 EGD99084.1 - 3.2e-09 37.0 0.0 8.6e-09 35.6 0.0 1.7 1 0 0 1 1 1 1 SWIRM domain ZZ PF00569.17 EGD99084.1 - 1.9e-08 34.0 4.6 3.4e-08 33.2 4.6 1.3 1 0 0 1 1 1 1 Zinc finger, ZZ type PG_binding_1 PF01471.18 EGD99084.1 - 0.015 15.5 0.0 0.05 13.8 0.0 1.9 1 0 0 1 1 1 0 Putative peptidoglycan binding domain DUF5112 PF17139.4 EGD99084.1 - 0.06 12.8 0.6 0.093 12.2 0.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5112) Pkinase PF00069.25 EGD99085.1 - 4.6e-70 236.0 0.0 5.9e-70 235.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD99085.1 - 3.9e-33 114.8 0.0 5.5e-33 114.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.24 EGD99085.1 - 1.5e-10 41.6 1.1 3.1e-10 40.6 0.2 2.1 2 1 0 2 2 2 1 Protein kinase C terminal domain Haspin_kinase PF12330.8 EGD99085.1 - 3.6e-06 26.2 0.1 5.5e-06 25.6 0.1 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 EGD99085.1 - 0.0063 15.9 0.0 0.01 15.2 0.0 1.3 1 0 0 1 1 1 1 Kinase-like C2 PF00168.30 EGD99085.1 - 0.024 14.9 0.0 0.052 13.8 0.0 1.5 1 0 0 1 1 1 0 C2 domain Coatomer_WDAD PF04053.14 EGD99086.1 - 4.1e-170 566.6 0.0 9.3e-170 565.5 0.0 1.6 2 0 0 2 2 2 1 Coatomer WD associated region WD40 PF00400.32 EGD99086.1 - 2e-38 129.7 4.5 2.9e-06 27.9 0.0 7.9 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EGD99086.1 - 3.5e-06 27.2 0.0 4.6 7.6 0.0 5.8 3 2 2 7 7 7 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EGD99086.1 - 0.0011 17.8 2.4 0.25 9.9 0.3 3.7 1 1 0 3 3 3 1 Nucleoporin Nup120/160 BBS2_Mid PF14783.6 EGD99086.1 - 0.091 12.8 0.0 13 5.9 0.0 3.5 2 2 1 3 3 3 0 Ciliary BBSome complex subunit 2, middle region ETC_C1_NDUFA5 PF04716.14 EGD99087.1 - 2e-26 91.6 6.6 1.7e-25 88.6 0.1 2.7 3 0 0 3 3 3 2 ETC complex I subunit conserved region DUF1192 PF06698.11 EGD99087.1 - 0.39 10.8 4.3 0.73 9.9 3.8 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1192) Thioredoxin PF00085.20 EGD99088.1 - 2.2e-43 146.5 0.0 2.4e-24 85.3 0.0 3.3 3 0 0 3 3 3 2 Thioredoxin Thioredoxin_6 PF13848.6 EGD99088.1 - 3.3e-11 43.5 0.0 8.1e-05 22.6 0.0 4.1 3 1 1 4 4 4 2 Thioredoxin-like domain Thioredoxin_8 PF13905.6 EGD99088.1 - 0.00049 20.4 0.0 0.47 10.8 0.0 3.9 3 0 0 3 3 3 1 Thioredoxin-like OST3_OST6 PF04756.13 EGD99088.1 - 0.001 18.5 0.0 0.2 11.0 0.0 2.6 2 0 0 2 2 2 2 OST3 / OST6 family, transporter family HyaE PF07449.11 EGD99088.1 - 0.0011 18.9 0.0 0.59 10.1 0.0 2.8 3 0 0 3 3 3 2 Hydrogenase-1 expression protein HyaE Thioredoxin_2 PF13098.6 EGD99088.1 - 0.0016 18.9 1.3 0.86 10.1 0.1 3.7 3 1 0 3 3 3 1 Thioredoxin-like domain TraF PF13728.6 EGD99088.1 - 0.0017 18.2 0.1 0.35 10.7 0.0 3.1 3 0 0 3 3 3 1 F plasmid transfer operon protein Thioredoxin_3 PF13192.6 EGD99088.1 - 0.033 14.2 1.1 0.38 10.8 0.0 2.9 3 0 0 3 3 3 0 Thioredoxin domain Thioredoxin_7 PF13899.6 EGD99088.1 - 0.06 13.5 1.7 0.28 11.4 0.1 2.8 3 0 0 3 3 3 0 Thioredoxin-like DAO PF01266.24 EGD99089.1 - 2.1e-31 109.8 0.3 3e-31 109.3 0.3 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EGD99089.1 - 0.013 15.7 0.0 0.062 13.5 0.0 2.2 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 EGD99089.1 - 0.079 12.2 0.0 0.11 11.7 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EGD99089.1 - 0.1 12.6 0.1 0.38 10.7 0.0 2.0 2 0 0 2 2 2 0 FAD-NAD(P)-binding Thi4 PF01946.17 EGD99089.1 - 0.15 11.3 0.0 0.26 10.5 0.0 1.4 1 0 0 1 1 1 0 Thi4 family TadE PF07811.12 EGD99089.1 - 3.9 7.8 5.4 1.1 9.6 0.7 2.2 2 0 0 2 2 2 0 TadE-like protein MFS_1 PF07690.16 EGD99090.1 - 2.9e-27 95.5 27.6 2.9e-27 95.5 27.6 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily HNH_2 PF13391.6 EGD99091.1 - 0.00011 22.3 0.0 0.00028 21.0 0.0 1.7 1 0 0 1 1 1 1 HNH endonuclease Na_Ca_ex PF01699.24 EGD99092.1 - 6.2e-41 139.9 43.8 8.3e-22 77.8 15.1 2.4 3 0 0 3 3 3 2 Sodium/calcium exchanger protein Cyt_bd_oxida_II PF02322.15 EGD99092.1 - 0.61 9.4 21.0 1.9 7.7 1.2 2.5 2 1 0 2 2 2 0 Cytochrome bd terminal oxidase subunit II Ribosomal_S7 PF00177.21 EGD99093.1 - 4.7e-29 101.0 0.0 8.4e-29 100.1 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e DUF1013 PF06242.11 EGD99093.1 - 0.017 15.2 0.6 0.29 11.2 0.2 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1013) Peptidase_S28 PF05577.12 EGD99095.1 - 1e-52 179.4 0.0 5.6e-52 177.0 0.0 1.8 1 1 0 1 1 1 1 Serine carboxypeptidase S28 Peptidase_S9 PF00326.21 EGD99095.1 - 0.079 12.4 0.1 0.2 11.1 0.0 1.7 2 0 0 2 2 2 0 Prolyl oligopeptidase family SPX PF03105.19 EGD99096.1 - 1.8e-41 143.4 0.3 1.3e-28 101.1 0.0 2.1 1 1 1 2 2 2 2 SPX domain Na_sulph_symp PF00939.19 EGD99096.1 - 2.1e-29 102.9 42.5 3e-29 102.4 42.5 1.1 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.16 EGD99096.1 - 1.9e-26 93.0 66.1 3e-24 85.8 41.0 2.4 2 1 1 3 3 3 2 Citrate transporter DUF4220 PF13968.6 EGD99096.1 - 0.011 15.2 0.2 0.011 15.2 0.2 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4220) Glycophorin_A PF01102.18 EGD99096.1 - 1.7 8.9 3.8 0.75 10.1 0.0 2.4 3 0 0 3 3 3 0 Glycophorin A Ribonuclease_T2 PF00445.18 EGD99097.1 - 6.3e-41 140.6 3.1 6.3e-41 140.6 1.6 1.6 2 0 0 2 2 2 1 Ribonuclease T2 family GT-D PF08759.11 EGD99097.1 - 0.003 17.2 0.6 0.0045 16.7 0.6 1.2 1 0 0 1 1 1 1 Glycosyltransferase GT-D fold Tissue_fac PF01108.17 EGD99097.1 - 0.99 9.3 5.0 5.6 6.9 0.1 2.4 1 1 1 2 2 2 0 Tissue factor Ribosomal_S8e PF01201.22 EGD99098.1 - 1.9e-55 186.8 1.4 2.2e-55 186.6 1.4 1.0 1 0 0 1 1 1 1 Ribosomal protein S8e NmrA PF05368.13 EGD99100.1 - 1.1e-15 57.8 0.0 2.3e-08 33.9 0.0 2.2 2 0 0 2 2 2 2 NmrA-like family NAD_binding_10 PF13460.6 EGD99100.1 - 2.2e-06 27.7 0.0 4.4e-06 26.7 0.0 1.5 1 0 0 1 1 1 1 NAD(P)H-binding Glyco_hydro_20 PF00728.22 EGD99101.1 - 1e-99 334.3 0.0 1.2e-99 334.0 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Glycohydro_20b2 PF14845.6 EGD99101.1 - 2.4e-24 86.5 0.0 9.9e-24 84.5 0.0 1.9 2 0 0 2 2 2 1 beta-acetyl hexosaminidase like Glyco_hydro_20b PF02838.15 EGD99101.1 - 3.8e-05 24.5 0.0 7.3e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, domain 2 AP_endonuc_2 PF01261.24 EGD99101.1 - 0.097 12.1 0.0 2.8 7.3 0.0 2.6 2 1 1 3 3 3 0 Xylose isomerase-like TIM barrel DOCK_N PF16172.5 EGD99102.1 - 2.4e-106 355.8 0.0 5.2e-106 354.7 0.0 1.5 1 0 0 1 1 1 1 DOCK N-terminus DHR-2 PF06920.13 EGD99102.1 - 4.7e-39 134.4 5.3 1.4e-38 132.9 5.3 1.7 1 1 0 1 1 1 1 Dock homology region 2 DOCK-C2 PF14429.6 EGD99102.1 - 2.3e-28 99.3 0.1 1.1e-27 97.1 0.0 2.1 2 0 0 2 2 2 1 C2 domain in Dock180 and Zizimin proteins SH3_1 PF00018.28 EGD99102.1 - 4.1e-05 23.1 0.0 0.00011 21.8 0.0 1.7 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EGD99102.1 - 0.00018 21.3 0.0 0.0017 18.2 0.0 2.3 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.17 EGD99102.1 - 0.1 12.3 0.0 0.22 11.2 0.0 1.6 1 0 0 1 1 1 0 Variant SH3 domain Sec3-PIP2_bind PF15277.6 EGD99103.1 - 1.8e-29 101.7 0.1 4e-29 100.6 0.1 1.6 1 0 0 1 1 1 1 Exocyst complex component SEC3 N-terminal PIP2 binding PH Sec3_C PF09763.9 EGD99103.1 - 8.6e-25 87.2 1.4 1.4e-24 86.5 1.4 1.3 1 0 0 1 1 1 1 Exocyst complex component Sec3 E_Pc_C PF06752.12 EGD99103.1 - 0.064 13.4 3.0 0.16 12.0 3.0 1.6 1 0 0 1 1 1 0 Enhancer of Polycomb C-terminus Tir_receptor_C PF07489.11 EGD99103.1 - 0.37 10.7 10.6 0.71 9.8 10.6 1.4 1 0 0 1 1 1 0 Translocated intimin receptor (Tir) C-terminus Mucin PF01456.17 EGD99103.1 - 0.78 9.7 18.4 2.5 8.1 18.4 1.8 1 0 0 1 1 1 0 Mucin-like glycoprotein DUF3439 PF11921.8 EGD99103.1 - 1.3 9.0 14.6 3 7.8 14.6 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) AJAP1_PANP_C PF15298.6 EGD99103.1 - 3.6 7.8 9.8 7.1 6.8 9.8 1.4 1 0 0 1 1 1 0 AJAP1/PANP C-terminus SSP160 PF06933.11 EGD99103.1 - 3.8 5.6 14.6 5.4 5.1 14.6 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 TPPII_N PF12583.8 EGD99103.1 - 4.3 7.9 6.3 12 6.4 6.3 1.8 1 0 0 1 1 1 0 Tripeptidyl peptidase II N terminal Dicty_REP PF05086.12 EGD99103.1 - 5.3 4.9 9.3 7.5 4.4 9.3 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein SRP40_C PF05022.12 EGD99104.1 - 2.3e-18 66.8 0.1 8.6e-18 65.0 0.1 2.0 1 0 0 1 1 1 1 SRP40, C-terminal domain F-box-like PF12937.7 EGD99105.1 - 2.2e-07 30.7 0.8 5.7e-07 29.3 0.8 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EGD99105.1 - 1.3e-05 24.9 0.1 3.4e-05 23.6 0.1 1.6 1 0 0 1 1 1 1 F-box domain Lactonase PF10282.9 EGD99105.1 - 0.15 11.3 0.0 0.33 10.2 0.0 1.5 1 1 0 1 1 1 0 Lactonase, 7-bladed beta-propeller HNH_2 PF13391.6 EGD99106.1 - 1.7e-09 37.7 0.0 3.6e-09 36.6 0.0 1.6 1 0 0 1 1 1 1 HNH endonuclease p450 PF00067.22 EGD99107.1 - 7.7e-48 163.4 0.0 8e-47 160.0 0.0 2.0 2 0 0 2 2 2 2 Cytochrome P450 Hit1_C PF18268.1 EGD99108.1 - 0.091 12.9 0.0 0.13 12.5 0.0 1.3 1 0 0 1 1 1 0 Hit1 C-terminal DUF1992 PF09350.10 EGD99109.1 - 1.3e-19 70.1 0.3 3.8e-19 68.6 0.3 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF1992) RPAP1_N PF08621.10 EGD99109.1 - 0.0069 16.1 0.2 1.8 8.4 0.0 3.1 2 0 0 2 2 2 2 RPAP1-like, N-terminal ALGX PF16822.5 EGD99109.1 - 0.055 13.1 0.3 1.6 8.3 0.1 2.4 2 0 0 2 2 2 0 SGNH hydrolase-like domain, acetyltransferase AlgX Shisa PF13908.6 EGD99111.1 - 1.1 9.5 0.0 1.1 9.5 0.0 3.1 3 2 0 3 3 3 0 Wnt and FGF inhibitory regulator Methyltransf_25 PF13649.6 EGD99112.1 - 0.0039 17.9 0.0 0.01 16.5 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Acetyltransf_8 PF13523.6 EGD99115.1 - 5.4e-28 97.5 0.0 8e-28 96.9 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain zn-ribbon_14 PF16503.5 EGD99116.1 - 1.4e-18 66.1 5.4 1.4e-18 66.1 5.4 3.7 4 0 0 4 4 4 1 Zinc-ribbon ATP_bind_3 PF01171.20 EGD99116.1 - 1.3e-11 44.6 0.0 2.1e-11 43.9 0.0 1.3 1 0 0 1 1 1 1 PP-loop family zf-UBR PF02207.20 EGD99116.1 - 0.95 9.7 6.8 1.8 8.8 0.7 2.5 2 0 0 2 2 2 0 Putative zinc finger in N-recognin (UBR box) RecR PF02132.15 EGD99116.1 - 1.2 8.8 9.8 0.05 13.2 1.6 2.7 3 0 0 3 3 3 0 RecR protein SBF PF01758.16 EGD99117.1 - 1.4e-53 181.5 12.2 1.4e-53 181.5 12.2 2.0 2 0 0 2 2 2 1 Sodium Bile acid symporter family Kinocilin PF15033.6 EGD99117.1 - 0.88 9.2 2.7 1.2 8.8 0.6 2.4 2 0 0 2 2 2 0 Kinocilin protein DUF1240 PF06836.12 EGD99117.1 - 3.7 8.2 6.7 0.55 10.8 0.5 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF1240) CD24 PF14984.6 EGD99118.1 - 0.17 12.1 0.2 3.9 7.8 0.0 2.3 2 0 0 2 2 2 0 CD24 protein Cyclin_N PF00134.23 EGD99120.1 - 2.2e-11 43.6 0.0 4.3e-11 42.7 0.0 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.11 EGD99120.1 - 4.6e-05 23.8 0.0 9.7e-05 22.8 0.0 1.5 1 0 0 1 1 1 1 Cyclin DUF3915 PF13054.6 EGD99120.1 - 0.0051 16.8 2.4 0.0096 15.9 2.4 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3915) Complex1_LYR_2 PF13233.6 EGD99121.1 - 3.6e-22 78.9 0.4 4.4e-22 78.6 0.4 1.1 1 0 0 1 1 1 1 Complex1_LYR-like CHD5 PF04420.14 EGD99121.1 - 0.021 14.7 0.0 0.022 14.7 0.0 1.1 1 0 0 1 1 1 0 CHD5-like protein zf-HIT PF04438.16 EGD99122.1 - 1.6e-09 37.5 7.9 2.4e-09 36.9 7.9 1.3 1 0 0 1 1 1 1 HIT zinc finger zf-B_box PF00643.24 EGD99122.1 - 0.19 11.9 8.2 0.33 11.1 8.2 1.3 1 0 0 1 1 1 0 B-box zinc finger DUF5320 PF17253.2 EGD99122.1 - 1.3 10.2 8.9 2.7 9.1 8.9 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5320) PolC_DP2 PF03833.13 EGD99122.1 - 2.8 5.7 4.9 3.1 5.5 4.9 1.1 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 RasGEF PF00617.19 EGD99123.1 - 3.2e-44 151.2 0.1 8.2e-44 149.9 0.1 1.7 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 EGD99123.1 - 5.1e-13 49.2 0.0 1.4e-12 47.8 0.0 1.7 1 0 0 1 1 1 1 RasGEF N-terminal motif Ras PF00071.22 EGD99123.1 - 0.0071 16.0 0.0 0.023 14.3 0.0 1.8 1 1 0 1 1 1 1 Ras family ATP_bind_1 PF03029.17 EGD99123.1 - 0.018 14.8 0.2 1.2 8.8 0.1 2.3 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_16 PF13191.6 EGD99123.1 - 0.032 14.6 0.1 0.23 11.8 0.0 2.3 2 0 0 2 2 2 0 AAA ATPase domain SPX PF03105.19 EGD99123.1 - 0.032 14.2 4.1 1.9 8.3 3.9 2.6 1 1 0 1 1 1 0 SPX domain NifU PF01106.17 EGD99124.1 - 1e-27 96.0 0.2 2.2e-27 95.0 0.1 1.6 2 0 0 2 2 2 1 NifU-like domain Nfu_N PF08712.11 EGD99124.1 - 2.6e-25 88.3 0.0 8.9e-25 86.6 0.0 1.9 2 0 0 2 2 2 1 Scaffold protein Nfu/NifU N terminal PSP1 PF04468.12 EGD99125.1 - 1.5e-28 98.9 2.6 2.4e-28 98.3 2.6 1.3 1 0 0 1 1 1 1 PSP1 C-terminal conserved region DUF2570 PF10828.8 EGD99125.1 - 6.5 6.6 6.1 2.2 8.2 0.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2570) Cornichon PF03311.14 EGD99126.1 - 3e-50 169.6 13.3 3.4e-50 169.4 13.3 1.0 1 0 0 1 1 1 1 Cornichon protein MFS_1 PF07690.16 EGD99127.1 - 1.1e-17 64.0 49.1 1.2e-16 60.6 30.5 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_3 PF05977.13 EGD99127.1 - 4.4e-07 28.7 2.2 9.1e-07 27.6 2.2 1.4 1 0 0 1 1 1 1 Transmembrane secretion effector TerC PF03741.16 EGD99127.1 - 0.0075 16.0 0.1 0.0075 16.0 0.1 2.6 2 1 0 2 2 2 1 Integral membrane protein TerC family ABC2_membrane PF01061.24 EGD99128.1 - 3.6e-39 134.4 18.5 6.1e-39 133.6 18.5 1.4 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.27 EGD99128.1 - 6.9e-27 94.6 0.1 1.3e-26 93.7 0.1 1.5 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 EGD99128.1 - 3.9e-06 26.9 0.0 0.07 12.9 0.0 2.4 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system EGF_2 PF07974.13 EGD99128.1 - 9.9e-05 22.6 11.8 9.9e-05 22.6 11.8 3.3 3 0 0 3 3 2 2 EGF-like domain ABC2_membrane_3 PF12698.7 EGD99128.1 - 0.00055 19.2 25.8 0.0018 17.4 24.9 2.5 2 1 0 2 2 2 1 ABC-2 family transporter protein AAA_29 PF13555.6 EGD99128.1 - 0.0069 16.1 0.2 0.018 14.8 0.2 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_23 PF13476.6 EGD99128.1 - 0.0093 16.5 0.1 0.022 15.3 0.1 1.7 1 0 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 EGD99128.1 - 0.022 14.7 0.0 0.045 13.7 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase SMC_N PF02463.19 EGD99128.1 - 0.022 14.2 0.1 0.12 11.8 0.1 2.0 1 1 0 1 1 1 0 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 EGD99128.1 - 0.037 14.3 0.0 0.11 12.8 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 EGD99128.1 - 0.037 14.2 0.0 0.09 12.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 EGD99128.1 - 0.04 14.5 0.0 0.12 12.9 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 EGD99128.1 - 0.055 13.0 0.1 0.17 11.4 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 EGD99128.1 - 0.076 13.4 0.0 0.16 12.3 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain ATP-synt_ab PF00006.25 EGD99128.1 - 0.11 12.2 0.1 0.21 11.2 0.0 1.5 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain cobW PF02492.19 EGD99128.1 - 0.17 11.5 0.0 0.77 9.3 0.0 1.9 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Aminotran_1_2 PF00155.21 EGD99129.1 - 9.9e-43 146.7 0.0 1.2e-42 146.4 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 EGD99129.1 - 4.2e-07 29.3 0.0 6.6e-07 28.6 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 EGD99129.1 - 1.7e-06 26.8 0.0 2.7e-06 26.2 0.0 1.1 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Beta_elim_lyase PF01212.21 EGD99129.1 - 2.3e-06 27.1 0.0 3.8e-06 26.4 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.17 EGD99129.1 - 0.0051 16.2 0.0 0.01 15.2 0.0 1.4 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Alliinase_C PF04864.13 EGD99129.1 - 0.2 10.5 0.0 0.6 8.9 0.0 1.7 1 1 0 2 2 2 0 Allinase Peptidase_M36 PF02128.15 EGD99130.1 - 3.2e-158 526.8 9.6 4.6e-158 526.2 9.6 1.2 1 0 0 1 1 1 1 Fungalysin metallopeptidase (M36) FTP PF07504.13 EGD99130.1 - 4.5e-16 58.4 4.2 9.2e-16 57.4 4.2 1.5 1 0 0 1 1 1 1 Fungalysin/Thermolysin Propeptide Motif Peptidase_M4_C PF02868.15 EGD99130.1 - 0.0002 21.3 0.0 0.001 19.0 0.0 2.2 2 0 0 2 2 2 1 Thermolysin metallopeptidase, alpha-helical domain AMP-binding PF00501.28 EGD99131.1 - 2.6e-67 227.3 0.0 3.8e-67 226.7 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EGD99131.1 - 4.8e-07 30.7 0.0 9.6e-07 29.7 0.0 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Lyase_1 PF00206.20 EGD99132.1 - 1.5e-85 287.3 0.0 2.4e-85 286.7 0.0 1.3 1 0 0 1 1 1 1 Lyase ASL_C2 PF14698.6 EGD99132.1 - 1.7e-23 83.1 0.0 4.4e-23 81.8 0.0 1.7 1 0 0 1 1 1 1 Argininosuccinate lyase C-terminal CNOT1_HEAT PF16418.5 EGD99132.1 - 0.095 12.8 0.0 0.31 11.1 0.0 1.8 2 0 0 2 2 2 0 CCR4-NOT transcription complex subunit 1 HEAT repeat Sulfatase PF00884.23 EGD99133.1 - 6.9e-22 78.2 0.2 1.4e-21 77.2 0.2 1.4 1 0 0 1 1 1 1 Sulfatase Phosphodiest PF01663.22 EGD99133.1 - 8.4e-06 25.6 0.0 1.6e-05 24.7 0.0 1.4 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase DUF229 PF02995.17 EGD99133.1 - 0.0053 15.4 0.0 0.0081 14.8 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF229) JmjC PF02373.22 EGD99134.1 - 6.4e-06 26.6 0.0 1.5e-05 25.4 0.0 1.7 1 0 0 1 1 1 1 JmjC domain, hydroxylase zf-4CXXC_R1 PF10497.9 EGD99134.1 - 8.6e-05 22.7 5.4 8.6e-05 22.7 5.4 2.4 2 0 0 2 2 2 1 Zinc-finger domain of monoamine-oxidase A repressor R1 ZZ PF00569.17 EGD99134.1 - 9.4e-05 22.1 8.0 9.4e-05 22.1 8.0 2.7 2 1 0 2 2 2 1 Zinc finger, ZZ type TackOD1 PF18551.1 EGD99134.1 - 0.0096 15.6 1.8 0.0096 15.6 1.8 2.3 1 1 1 2 2 2 1 Thaumarchaeal output domain 1 C1_2 PF03107.16 EGD99134.1 - 0.023 15.0 2.2 0.023 15.0 2.2 2.9 2 0 0 2 2 2 0 C1 domain Baculo_IE-1 PF05290.11 EGD99134.1 - 0.059 13.3 7.7 0.04 13.9 1.6 2.3 2 0 0 2 2 2 0 Baculovirus immediate-early protein (IE-0) Cupin_2 PF07883.11 EGD99134.1 - 0.16 11.7 0.0 0.33 10.7 0.0 1.5 1 0 0 1 1 1 0 Cupin domain DUF1179 PF06678.11 EGD99135.1 - 0.27 11.2 0.1 0.27 11.2 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1179) Polyketide_cyc PF03364.20 EGD99136.1 - 1.1e-19 70.9 0.0 2.1e-19 70.0 0.0 1.5 1 1 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Sod_Fe_C PF02777.18 EGD99137.1 - 1.3e-18 67.0 0.0 6.7e-08 32.6 0.0 2.2 2 0 0 2 2 2 2 Iron/manganese superoxide dismutases, C-terminal domain Orthoreo_P10 PF07204.11 EGD99138.1 - 0.055 13.4 0.2 0.73 9.8 0.0 2.5 3 0 0 3 3 3 0 Orthoreovirus membrane fusion protein p10 PIG-S PF10510.9 EGD99139.1 - 1.1e-154 516.1 9.1 1.5e-139 466.2 2.5 2.0 1 1 1 2 2 2 2 Phosphatidylinositol-glycan biosynthesis class S protein ANAPC4_WD40 PF12894.7 EGD99140.1 - 1.9e-06 28.1 0.0 0.0019 18.5 0.0 2.8 2 0 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain TLP-20 PF06088.11 EGD99140.1 - 0.016 15.1 2.2 0.024 14.5 2.2 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) RR_TM4-6 PF06459.12 EGD99140.1 - 0.21 11.4 1.6 0.29 10.9 1.6 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 PQQ_3 PF13570.6 EGD99140.1 - 0.34 11.5 4.7 4 8.1 0.1 4.0 3 1 1 4 4 4 0 PQQ-like domain CDC45 PF02724.14 EGD99140.1 - 0.47 8.7 7.3 0.64 8.2 7.3 1.1 1 0 0 1 1 1 0 CDC45-like protein WD40 PF00400.32 EGD99140.1 - 2.5 9.1 9.1 1.3e+02 3.7 0.3 5.2 6 0 0 6 6 6 0 WD domain, G-beta repeat FAM176 PF14851.6 EGD99140.1 - 3.2 7.4 4.9 5.3 6.7 4.9 1.3 1 0 0 1 1 1 0 FAM176 family Fe-ADH PF00465.19 EGD99142.1 - 5.5e-68 229.4 2.5 6.2e-68 229.2 2.5 1.0 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.6 EGD99142.1 - 1.4e-10 41.3 2.1 2e-10 40.8 2.1 1.1 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Diphthamide_syn PF01866.17 EGD99143.1 - 7.4e-86 288.3 0.0 1.4e-85 287.4 0.0 1.5 1 1 0 1 1 1 1 Putative diphthamide synthesis protein DUF1923 PF09083.10 EGD99143.1 - 0.054 13.2 0.1 15 5.3 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF1923) PCM1_C PF15717.5 EGD99143.1 - 0.13 11.0 1.3 0.19 10.4 1.3 1.2 1 0 0 1 1 1 0 Pericentriolar material 1 C terminus Methyltransf_12 PF08242.12 EGD99146.1 - 1.2e-15 58.0 0.0 5.2e-15 56.0 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EGD99146.1 - 5.8e-14 52.6 0.0 1.2e-13 51.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EGD99146.1 - 4.2e-12 46.6 0.0 1e-11 45.3 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EGD99146.1 - 7.2e-11 42.2 0.0 1.3e-10 41.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EGD99146.1 - 1.2e-08 34.9 0.0 1.9e-08 34.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EGD99146.1 - 4.3e-05 23.0 0.0 6.9e-05 22.3 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family NNMT_PNMT_TEMT PF01234.17 EGD99146.1 - 0.0002 20.6 0.0 0.024 13.9 0.0 2.1 1 1 1 2 2 2 2 NNMT/PNMT/TEMT family Methyltransf_24 PF13578.6 EGD99146.1 - 0.0016 19.4 0.0 0.0033 18.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EGD99146.1 - 0.0018 17.8 0.1 0.003 17.1 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_16 PF10294.9 EGD99146.1 - 0.0082 15.9 0.0 0.013 15.3 0.0 1.2 1 0 0 1 1 1 1 Lysine methyltransferase TehB PF03848.14 EGD99146.1 - 0.065 12.6 0.0 0.12 11.8 0.0 1.4 1 0 0 1 1 1 0 Tellurite resistance protein TehB CMAS PF02353.20 EGD99146.1 - 0.074 12.3 0.0 0.12 11.6 0.0 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_8 PF05148.15 EGD99146.1 - 0.11 12.3 0.0 0.24 11.2 0.0 1.5 1 1 0 1 1 1 0 Hypothetical methyltransferase Methyltransf_32 PF13679.6 EGD99146.1 - 0.14 12.1 0.0 0.23 11.5 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Sugar_tr PF00083.24 EGD99147.1 - 8.2e-121 404.0 17.4 1.5e-120 403.2 17.4 1.4 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EGD99147.1 - 3.4e-23 82.1 42.0 5.8e-14 51.8 15.0 2.5 1 1 1 2 2 2 2 Major Facilitator Superfamily HlyIII PF03006.20 EGD99148.1 - 2.9e-61 207.1 22.1 3.5e-61 206.8 22.1 1.1 1 0 0 1 1 1 1 Haemolysin-III related Asr PF06392.11 EGD99148.1 - 0.043 14.2 0.7 0.082 13.3 0.7 1.4 1 0 0 1 1 1 0 Acid shock protein repeat GlnD_UR_UTase PF08335.11 EGD99148.1 - 0.4 10.8 5.3 1.5 8.9 0.8 2.2 1 1 0 2 2 2 0 GlnD PII-uridylyltransferase FmiP_Thoc5 PF09766.9 EGD99149.1 - 1.7e-33 116.4 10.5 2.4e-33 115.9 10.5 1.2 1 0 0 1 1 1 1 Fms-interacting protein/Thoc5 Casc1_N PF15927.5 EGD99149.1 - 0.0041 16.8 14.4 0.02 14.6 8.7 2.4 2 0 0 2 2 2 2 Cancer susceptibility candidate 1 N-terminus DUF948 PF06103.11 EGD99149.1 - 0.011 16.0 1.3 0.49 10.7 0.0 2.9 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) SPATA1_C PF15743.5 EGD99149.1 - 0.012 15.7 3.3 0.012 15.7 3.3 2.2 2 0 0 2 2 2 0 Spermatogenesis-associated C-terminus Flagellin_N PF00669.20 EGD99149.1 - 0.035 14.2 0.7 0.035 14.2 0.7 2.2 2 1 1 3 3 3 0 Bacterial flagellin N-terminal helical region DUF4200 PF13863.6 EGD99149.1 - 0.06 13.7 12.9 0.11 12.9 0.4 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) DUF349 PF03993.12 EGD99149.1 - 0.41 11.0 11.0 0.057 13.7 5.8 2.2 2 1 0 2 2 2 0 Domain of Unknown Function (DUF349) DDE_Tnp_ISL3 PF01610.17 EGD99149.1 - 0.98 9.1 6.7 0.28 10.9 1.6 2.1 2 1 1 3 3 3 0 Transposase APG6_N PF17675.1 EGD99149.1 - 1.1 9.7 20.4 1.6 9.3 9.3 2.3 2 1 0 2 2 2 0 Apg6 coiled-coil region DUF4140 PF13600.6 EGD99149.1 - 1.5 9.3 9.2 4.9 7.7 0.3 2.5 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) Mod_r PF07200.13 EGD99149.1 - 3.5 7.7 17.8 1 9.4 6.0 2.4 2 1 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein YabA PF06156.13 EGD99149.1 - 3.9 8.2 11.2 5.4 7.7 2.1 2.6 2 1 0 2 2 2 0 Initiation control protein YabA HAUS-augmin3 PF14932.6 EGD99149.1 - 4.1 6.9 16.9 4.1 6.9 3.0 2.1 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 3 DIE2_ALG10 PF04922.12 EGD99150.1 - 2.6e-110 369.4 9.6 2.7e-56 191.5 0.1 2.1 2 0 0 2 2 2 2 DIE2/ALG10 family Sld5 PF05916.11 EGD99151.1 - 2.3e-32 111.7 0.0 5.7e-32 110.4 0.0 1.6 1 1 0 1 1 1 1 GINS complex protein CUE PF02845.16 EGD99152.1 - 4.2e-10 39.1 0.0 6.7e-10 38.5 0.0 1.4 1 0 0 1 1 1 1 CUE domain G2BR PF18442.1 EGD99152.1 - 0.0097 15.5 10.6 0.018 14.7 10.6 1.4 1 0 0 1 1 1 1 E3 gp78 Ube2g2-binding region (G2BR) SMC_N PF02463.19 EGD99153.1 - 2.5e-70 236.3 0.0 1.2e-69 234.1 0.0 2.0 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 EGD99153.1 - 2.1e-20 73.2 1.1 1.3e-19 70.6 0.3 2.6 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_23 PF13476.6 EGD99153.1 - 1.1e-09 39.1 13.1 1.1e-09 39.1 13.1 6.7 2 2 2 4 4 4 1 AAA domain AAA_21 PF13304.6 EGD99153.1 - 4.3e-09 36.6 10.0 0.00057 19.8 0.0 3.9 4 0 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EGD99153.1 - 0.001 18.8 0.1 0.0025 17.5 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain MscS_porin PF12795.7 EGD99153.1 - 0.0016 18.0 18.2 0.0016 18.0 18.2 5.6 3 2 2 5 5 5 1 Mechanosensitive ion channel porin domain HIP1_clath_bdg PF16515.5 EGD99153.1 - 0.0062 17.1 11.5 0.0062 17.1 11.5 8.9 3 2 6 10 10 10 1 Clathrin-binding domain of Huntingtin-interacting protein 1 ABC_tran PF00005.27 EGD99153.1 - 0.07 13.6 0.1 0.07 13.6 0.1 5.4 4 2 0 4 4 4 0 ABC transporter SLATT_5 PF18160.1 EGD99153.1 - 4.7 6.5 11.9 0.11 11.8 0.5 3.4 3 0 0 3 3 3 0 SMODS and SLOG-associating 2TM effector domain family 5 GDI PF00996.18 EGD99154.1 - 2.8e-191 635.8 0.0 3.5e-191 635.4 0.0 1.0 1 0 0 1 1 1 1 GDP dissociation inhibitor NAD_binding_8 PF13450.6 EGD99154.1 - 0.026 14.7 0.0 0.16 12.2 0.0 2.2 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 EGD99154.1 - 0.17 12.5 0.2 1.4 9.5 0.1 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase MRP-L47 PF06984.13 EGD99155.1 - 1.1e-20 73.5 0.2 1.8e-20 72.9 0.2 1.3 1 0 0 1 1 1 1 Mitochondrial 39-S ribosomal protein L47 (MRP-L47) NOT2_3_5 PF04153.18 EGD99156.1 - 4.6e-27 94.7 0.1 4.6e-27 94.7 0.1 2.1 2 0 0 2 2 2 1 NOT2 / NOT3 / NOT5 family CCDC53 PF10152.9 EGD99156.1 - 0.49 10.8 14.4 0.083 13.3 6.7 2.3 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex BORG_CEP PF14957.6 EGD99156.1 - 0.91 10.7 15.4 1.5 10.0 7.6 2.4 2 0 0 2 2 2 0 Cdc42 effector 4HBT PF03061.22 EGD99157.1 - 3.2e-11 43.4 0.1 4.7e-11 42.9 0.1 1.3 1 0 0 1 1 1 1 Thioesterase superfamily CDC73_C PF05179.14 EGD99158.1 - 1.2e-58 197.3 0.0 1.8e-58 196.7 0.0 1.3 1 0 0 1 1 1 1 RNA pol II accessory factor, Cdc73 family, C-terminal X PF00739.19 EGD99158.1 - 0.27 11.4 0.1 0.27 11.4 0.1 2.5 3 1 0 3 3 3 0 Trans-activation protein X AA_permease PF00324.21 EGD99159.1 - 9.8e-78 261.9 24.1 1.1e-77 261.7 24.1 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EGD99159.1 - 3.7e-14 52.4 23.2 3.9e-14 52.3 23.2 1.0 1 0 0 1 1 1 1 Amino acid permease DUF1772 PF08592.11 EGD99159.1 - 1.6 9.0 16.5 0.2 11.9 8.6 3.0 1 1 0 2 2 2 0 Domain of unknown function (DUF1772) Abhydrolase_1 PF00561.20 EGD99160.1 - 6.3e-09 35.9 0.0 2.1e-08 34.2 0.0 1.9 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EGD99160.1 - 0.00026 20.3 0.0 0.0015 17.9 0.0 2.0 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Glutaredoxin PF00462.24 EGD99161.1 - 2.2e-12 47.0 0.0 3.4e-12 46.4 0.0 1.3 1 0 0 1 1 1 1 Glutaredoxin Ribosomal_L6 PF00347.23 EGD99162.1 - 4.1e-23 81.9 6.5 7.6e-11 42.5 0.4 2.2 2 0 0 2 2 2 2 Ribosomal protein L6 RXT2_N PF08595.11 EGD99163.1 - 7.7e-33 113.7 0.1 7.7e-33 113.7 0.1 3.2 2 1 0 2 2 2 1 RXT2-like, N-terminal PEMT PF04191.13 EGD99164.1 - 5.6e-34 116.7 2.0 3.8e-33 114.0 1.3 2.1 2 0 0 2 2 2 1 Phospholipid methyltransferase UAA PF08449.11 EGD99164.1 - 0.034 13.3 0.1 0.064 12.5 0.1 1.3 1 0 0 1 1 1 0 UAA transporter family DUF924 PF06041.11 EGD99165.1 - 1.7e-49 168.4 0.1 2e-49 168.2 0.1 1.0 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF924) SUR7 PF06687.12 EGD99166.1 - 1.9e-35 122.4 7.7 1.9e-35 122.4 7.7 1.3 1 1 0 1 1 1 1 SUR7/PalI family Acetyltransf_1 PF00583.25 EGD99168.1 - 1.3e-11 44.8 0.0 1.8e-11 44.3 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EGD99168.1 - 3.1e-08 33.6 0.0 4.3e-08 33.2 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EGD99168.1 - 3.9e-07 29.9 0.0 6.8e-07 29.2 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_7 PF13508.7 EGD99168.1 - 1.7e-05 25.2 0.0 2.6e-05 24.6 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EGD99168.1 - 0.0028 17.7 0.1 0.0051 16.9 0.1 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain TelA PF05816.11 EGD99169.1 - 0.0017 17.5 4.1 0.0017 17.5 4.1 2.3 3 0 0 3 3 3 1 Toxic anion resistance protein (TelA) SR-25 PF10500.9 EGD99169.1 - 0.0052 16.4 21.5 0.0052 16.4 21.5 3.4 2 1 0 3 3 3 1 Nuclear RNA-splicing-associated protein IMUP PF15761.5 EGD99169.1 - 0.027 15.2 9.4 0.027 15.2 9.4 3.5 3 0 0 3 3 3 0 Immortalisation up-regulated protein Herpes_pp85 PF04637.12 EGD99169.1 - 3.6 5.9 8.0 6.3 5.1 8.0 1.3 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) Golgin_A5 PF09787.9 EGD99169.1 - 5.9 6.3 36.2 0.21 11.0 13.0 3.0 3 0 0 3 3 3 0 Golgin subfamily A member 5 YscO PF07321.12 EGD99169.1 - 9.3 6.2 40.2 0.25 11.3 12.5 4.0 4 0 0 4 4 4 0 Type III secretion protein YscO Pkinase PF00069.25 EGD99170.1 - 1.4e-10 41.0 0.0 3.3e-10 39.8 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain HEAT PF02985.22 EGD99170.1 - 5.5e-07 29.3 1.7 0.16 12.3 0.0 5.0 6 0 0 6 6 6 2 HEAT repeat Cnd1 PF12717.7 EGD99170.1 - 7e-06 26.2 0.0 3.4e-05 23.9 0.0 2.1 1 1 1 2 2 2 1 non-SMC mitotic condensation complex subunit 1 Pkinase_Tyr PF07714.17 EGD99170.1 - 1.4e-05 24.5 0.0 2.5e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase HEAT_EZ PF13513.6 EGD99170.1 - 0.00013 22.4 0.1 4.3 7.9 0.0 4.3 4 0 0 4 4 4 2 HEAT-like repeat HEAT_2 PF13646.6 EGD99170.1 - 0.00073 19.9 0.4 0.22 11.9 0.1 3.9 2 1 2 4 4 4 2 HEAT repeats Kinase-like PF14531.6 EGD99170.1 - 0.013 14.9 0.0 0.024 14.0 0.0 1.4 1 0 0 1 1 1 0 Kinase-like CoA_trans PF01144.23 EGD99170.1 - 0.15 11.4 0.0 0.29 10.5 0.0 1.3 1 0 0 1 1 1 0 Coenzyme A transferase Adaptin_N PF01602.20 EGD99170.1 - 0.17 10.4 0.0 1.6 7.2 0.0 1.9 1 1 1 2 2 2 0 Adaptin N terminal region LsmAD PF06741.13 EGD99172.1 - 1.5e-27 96.0 6.0 4.3e-27 94.4 6.0 1.9 1 0 0 1 1 1 1 LsmAD domain SM-ATX PF14438.6 EGD99172.1 - 8.1e-20 70.8 0.0 1.8e-19 69.7 0.0 1.6 1 0 0 1 1 1 1 Ataxin 2 SM domain AIP3 PF03915.13 EGD99173.1 - 2.8e-153 510.9 3.7 2.8e-153 510.9 3.7 1.6 2 0 0 2 2 2 1 Actin interacting protein 3 MIP-T3_C PF17749.1 EGD99173.1 - 0.00082 19.4 4.0 0.014 15.4 0.6 3.6 3 0 0 3 3 3 1 Microtubule-binding protein MIP-T3 C-terminal region Lectin_N PF03954.14 EGD99173.1 - 0.056 13.2 2.3 0.12 12.1 0.1 2.6 2 0 0 2 2 2 0 Hepatic lectin, N-terminal domain Syntaxin_2 PF14523.6 EGD99173.1 - 0.35 11.2 6.9 1.8 9.0 0.1 3.9 3 1 1 4 4 4 0 Syntaxin-like protein Med11 PF10280.9 EGD99173.1 - 0.49 10.9 0.0 0.49 10.9 0.0 3.3 3 0 0 3 3 3 0 Mediator complex protein RasGAP_C PF03836.15 EGD99173.1 - 4 7.6 12.1 0.47 10.6 0.3 4.1 5 0 0 5 5 5 0 RasGAP C-terminus CAP_N PF01213.19 EGD99174.1 - 1.9 7.9 7.3 2.5 7.5 7.3 1.1 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Mito_fiss_reg PF05308.11 EGD99174.1 - 2.5 8.1 6.5 4 7.4 6.5 1.2 1 0 0 1 1 1 0 Mitochondrial fission regulator VIR_N PF15912.5 EGD99174.1 - 5.3 6.6 6.5 7.5 6.1 6.5 1.2 1 0 0 1 1 1 0 Virilizer, N-terminal ACOX PF01756.19 EGD99175.1 - 7.5e-46 156.0 0.0 1.3e-45 155.2 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA oxidase Acyl-CoA_ox_N PF14749.6 EGD99175.1 - 1.8e-30 106.1 0.7 3.8e-30 105.0 0.7 1.6 1 0 0 1 1 1 1 Acyl-coenzyme A oxidase N-terminal Acyl-CoA_dh_M PF02770.19 EGD99175.1 - 2.9e-10 40.2 0.0 1.2e-09 38.3 0.0 2.0 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_1 PF00441.24 EGD99175.1 - 7e-07 29.6 0.0 0.0013 18.9 0.0 2.4 2 0 0 2 2 2 2 Acyl-CoA dehydrogenase, C-terminal domain ESSS PF10183.9 EGD99176.1 - 7.2e-15 55.1 0.0 8e-15 54.9 0.0 1.1 1 0 0 1 1 1 1 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) RNB PF00773.19 EGD99177.1 - 2.8e-97 326.0 0.1 5e-97 325.2 0.1 1.4 1 0 0 1 1 1 1 RNB domain Rrp44_CSD1 PF17216.3 EGD99177.1 - 6.4e-28 97.3 0.1 2e-27 95.7 0.1 1.9 1 1 0 1 1 1 1 Rrp44-like cold shock domain Rrp44_S1 PF17215.3 EGD99177.1 - 1.3e-26 92.4 1.2 3.2e-26 91.1 1.2 1.7 1 0 0 1 1 1 1 S1 domain OB_Dis3 PF17849.1 EGD99177.1 - 3.4e-21 75.0 0.0 9.5e-21 73.6 0.0 1.8 1 0 0 1 1 1 1 Dis3-like cold-shock domain 2 (CSD2) PIN_4 PF13638.6 EGD99177.1 - 3.9e-12 46.6 0.5 1.6e-11 44.6 0.2 2.2 2 0 0 2 2 2 1 PIN domain CSD2 PF17876.1 EGD99177.1 - 2.7e-10 40.3 0.1 1.7e-06 28.1 0.0 3.1 2 0 0 2 2 2 2 Cold shock domain MFS_1 PF07690.16 EGD99178.1 - 1.9e-28 99.4 68.5 1.1e-22 80.5 37.2 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 EGD99178.1 - 9.5e-09 34.3 26.4 1.3e-05 23.9 8.6 2.7 1 1 0 2 2 2 2 MFS/sugar transport protein MFS_1_like PF12832.7 EGD99178.1 - 0.0014 17.6 17.6 0.058 12.2 0.3 2.7 2 1 0 2 2 2 2 MFS_1 like family LIM PF00412.22 EGD99179.1 - 5.6e-27 93.8 19.6 2e-10 40.8 2.8 4.0 3 1 0 3 3 3 3 LIM domain Zn_ribbon_recom PF13408.6 EGD99179.1 - 0.0081 16.6 0.1 0.0081 16.6 0.1 2.5 3 0 0 3 3 3 1 Recombinase zinc beta ribbon domain DZR PF12773.7 EGD99179.1 - 1.3 9.1 25.4 29 4.8 3.2 4.6 2 1 1 3 3 3 0 Double zinc ribbon Methyltransf_4 PF02390.17 EGD99180.1 - 6.3e-47 159.2 0.1 9.1e-46 155.5 0.1 2.5 1 1 0 1 1 1 1 Putative methyltransferase Methyltransf_25 PF13649.6 EGD99180.1 - 0.001 19.7 0.0 0.0099 16.6 0.0 2.6 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_31 PF13847.6 EGD99180.1 - 0.0072 16.1 0.0 0.013 15.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EGD99180.1 - 0.0075 15.8 0.0 0.17 11.4 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_12 PF08242.12 EGD99180.1 - 0.013 16.3 0.0 0.044 14.5 0.0 1.9 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_11 PF08241.12 EGD99180.1 - 0.061 14.0 0.0 4.9 7.9 0.0 3.3 4 0 0 4 4 4 0 Methyltransferase domain ESCRT-II PF05871.12 EGD99181.1 - 1.2e-51 174.7 1.0 1.3e-51 174.5 0.4 1.3 2 0 0 2 2 2 1 ESCRT-II complex subunit RTT107_BRCT_5 PF16770.5 EGD99182.1 - 4e-35 119.7 0.0 3.5e-31 107.0 0.0 4.3 4 0 0 4 4 4 1 Regulator of Ty1 transposition protein 107 BRCT domain PTCB-BRCT PF12738.7 EGD99182.1 - 1.2e-31 108.5 1.5 2e-17 62.9 0.3 5.7 5 1 0 5 5 5 3 twin BRCT domain BRCT PF00533.26 EGD99182.1 - 1.6e-31 108.5 0.0 1.9e-08 34.5 0.0 6.8 6 1 0 6 6 6 6 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 EGD99182.1 - 1.5e-30 105.5 0.0 5.1e-05 23.6 0.0 6.4 6 0 0 6 6 6 6 BRCT domain, a BRCA1 C-terminus domain LIG3_BRCT PF16759.5 EGD99182.1 - 4e-08 33.4 0.0 0.055 13.8 0.0 4.5 4 0 0 4 4 4 2 DNA ligase 3 BRCT domain BRCT_3 PF18428.1 EGD99182.1 - 0.018 15.1 0.4 4.5 7.4 0.0 3.3 3 0 0 3 3 3 0 BRCA1 C Terminus (BRCT) domain Ofd1_CTDD PF10637.9 EGD99182.1 - 0.08 12.3 0.0 0.3 10.4 0.0 1.8 1 1 1 2 2 2 0 Oxoglutarate and iron-dependent oxygenase degradation C-term Abhydrolase_6 PF12697.7 EGD99183.1 - 3.4e-10 40.9 0.0 5.4e-10 40.3 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EGD99183.1 - 0.00034 20.0 0.0 0.00054 19.3 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 IL8 PF00048.20 EGD99183.1 - 0.11 12.7 0.6 0.24 11.6 0.6 1.6 1 0 0 1 1 1 0 Small cytokines (intecrine/chemokine), interleukin-8 like Abhydrolase_1 PF00561.20 EGD99183.1 - 0.12 12.0 0.0 1.4 8.5 0.0 2.1 2 0 0 2 2 2 0 alpha/beta hydrolase fold Ndr PF03096.14 EGD99183.1 - 0.18 10.5 0.0 0.26 10.0 0.0 1.2 1 0 0 1 1 1 0 Ndr family Ceramidase PF05875.12 EGD99184.1 - 1.7e-105 352.2 10.3 2e-105 352.0 10.3 1.0 1 0 0 1 1 1 1 Ceramidase DUF2070 PF09843.9 EGD99184.1 - 0.063 11.6 1.1 0.078 11.2 1.1 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) RhlB PF12300.8 EGD99185.1 - 0.0044 17.2 2.8 0.0061 16.7 2.8 1.1 1 0 0 1 1 1 1 ATP-dependent RNA helicase RhlB Toxin_29 PF08116.11 EGD99185.1 - 0.15 12.0 0.7 0.15 12.0 0.7 3.4 4 0 0 4 4 4 0 PhTx neurotoxin family Nodulin_late PF07127.11 EGD99185.1 - 0.28 11.6 6.7 3 8.3 1.0 3.0 2 1 1 3 3 3 0 Late nodulin protein RTA1 PF04479.13 EGD99187.1 - 1.8e-34 119.2 6.5 3e-34 118.4 6.5 1.3 1 0 0 1 1 1 1 RTA1 like protein Claudin_3 PF06653.11 EGD99187.1 - 0.071 13.0 4.9 0.18 11.7 4.9 1.8 1 0 0 1 1 1 0 Tight junction protein, Claudin-like LCE PF14672.6 EGD99188.1 - 1.3 9.7 11.7 0.45 11.1 8.3 2.1 2 0 0 2 2 2 0 Late cornified envelope BTB PF00651.31 EGD99189.1 - 0.00033 20.8 0.0 0.00063 19.9 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain HAD PF12710.7 EGD99190.1 - 3.3e-27 96.1 0.0 4.3e-27 95.8 0.0 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase UMPH-1 PF05822.12 EGD99190.1 - 0.00015 21.4 0.0 0.00085 18.9 0.0 1.9 1 1 0 2 2 2 1 Pyrimidine 5'-nucleotidase (UMPH-1) Put_Phosphatase PF06888.12 EGD99190.1 - 0.00038 19.9 0.0 0.13 11.6 0.0 2.1 2 0 0 2 2 2 2 Putative Phosphatase Hydrolase PF00702.26 EGD99190.1 - 0.16 12.2 1.4 12 6.2 1.4 2.9 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase HECT PF00632.25 EGD99191.1 - 2.9e-78 263.4 0.0 2.2e-77 260.6 0.0 2.1 2 0 0 2 2 2 1 HECT-domain (ubiquitin-transferase) Adaptin_N PF01602.20 EGD99191.1 - 0.0098 14.5 0.1 0.0098 14.5 0.1 2.1 3 0 0 3 3 3 1 Adaptin N terminal region HEAT PF02985.22 EGD99191.1 - 0.029 14.6 0.3 4 8.0 0.1 3.6 3 0 0 3 3 3 0 HEAT repeat HEAT_EZ PF13513.6 EGD99191.1 - 0.068 13.7 0.1 0.53 10.9 0.0 2.5 2 0 0 2 2 2 0 HEAT-like repeat Arm PF00514.23 EGD99191.1 - 0.09 12.9 9.7 32 4.7 0.1 6.5 6 1 1 7 7 7 0 Armadillo/beta-catenin-like repeat F-box-like PF12937.7 EGD99193.1 - 0.0076 16.1 0.0 0.016 15.1 0.0 1.5 1 0 0 1 1 1 1 F-box-like SMG1 PF15785.5 EGD99194.1 - 0.61 8.4 4.8 1 7.7 4.8 1.2 1 0 0 1 1 1 0 Serine/threonine-protein kinase smg-1 DALR_1 PF05746.15 EGD99194.1 - 5.2 7.3 9.6 25 5.1 4.1 2.6 2 1 0 2 2 2 0 DALR anticodon binding domain COesterase PF00135.28 EGD99195.1 - 3.6e-85 286.8 0.0 4.2e-84 283.3 0.0 1.9 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EGD99195.1 - 2.6e-09 37.3 0.4 1.3e-08 35.0 0.2 2.2 2 1 0 2 2 2 1 alpha/beta hydrolase fold DUF3185 PF11381.8 EGD99195.1 - 0.47 10.5 1.9 1.3 9.1 0.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3185) F-actin_cap_A PF01267.17 EGD99196.1 - 5.6e-93 311.2 0.0 6.4e-93 311.0 0.0 1.0 1 0 0 1 1 1 1 F-actin capping protein alpha subunit PepSY_2 PF13670.6 EGD99198.1 - 0.062 13.3 1.4 0.12 12.4 1.4 1.5 1 0 0 1 1 1 0 Peptidase propeptide and YPEB domain Med7 PF05983.11 EGD99200.1 - 2.2e-51 174.7 0.2 2.2e-51 174.7 0.2 1.4 2 0 0 2 2 2 1 MED7 protein DUF4407 PF14362.6 EGD99200.1 - 0.14 11.5 1.2 0.2 11.0 1.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) HEAT_EZ PF13513.6 EGD99201.1 - 2.6e-19 69.3 2.0 1.1e-05 25.7 0.0 9.5 9 2 1 10 10 10 3 HEAT-like repeat HEAT PF02985.22 EGD99201.1 - 7.3e-19 66.3 3.7 0.00048 20.2 0.1 9.2 9 0 0 9 9 9 3 HEAT repeat HEAT_2 PF13646.6 EGD99201.1 - 9.3e-18 64.4 1.2 0.00036 20.9 0.0 6.9 6 1 1 7 7 7 4 HEAT repeats IFRD PF05004.13 EGD99201.1 - 6.3e-11 41.9 1.4 0.00082 18.6 0.1 4.7 2 1 3 5 5 5 2 Interferon-related developmental regulator (IFRD) Vac14_Fab1_bd PF12755.7 EGD99201.1 - 4.3e-07 30.4 0.0 1.7 9.3 0.0 6.2 6 1 1 7 7 7 1 Vacuolar 14 Fab1-binding region Cnd1 PF12717.7 EGD99201.1 - 1.4e-06 28.4 0.4 1.3 9.0 0.0 4.9 5 0 0 5 5 4 2 non-SMC mitotic condensation complex subunit 1 MMS19_C PF12460.8 EGD99201.1 - 4e-06 26.2 0.2 4.2e-05 22.9 0.0 2.7 3 0 0 3 3 3 1 RNAPII transcription regulator C-terminal ParcG PF10274.9 EGD99201.1 - 0.00041 20.5 0.1 0.047 13.8 0.1 2.9 2 0 0 2 2 2 1 Parkin co-regulated protein CLASP_N PF12348.8 EGD99201.1 - 0.0016 18.1 1.6 0.12 12.0 0.0 3.9 5 1 0 5 5 5 1 CLASP N terminal RIX1 PF08167.12 EGD99201.1 - 0.008 15.9 0.0 0.3 10.8 0.0 3.4 3 1 0 3 3 3 1 rRNA processing/ribosome biogenesis Ecm29 PF13001.7 EGD99201.1 - 0.0086 14.8 0.6 0.17 10.5 0.0 3.0 2 1 0 3 3 3 1 Proteasome stabiliser RTP1_C1 PF10363.9 EGD99201.1 - 0.009 16.2 0.4 2.4 8.4 0.0 4.1 4 0 0 4 4 4 1 Required for nuclear transport of RNA pol II C-terminus 1 UNC45-central PF11701.8 EGD99201.1 - 0.011 15.7 0.1 0.055 13.4 0.1 2.3 1 1 0 1 1 1 0 Myosin-binding striated muscle assembly central Arm PF00514.23 EGD99201.1 - 0.023 14.7 1.3 73 3.6 0.0 5.3 6 0 0 6 6 5 0 Armadillo/beta-catenin-like repeat Tti2 PF10521.9 EGD99201.1 - 0.028 13.9 0.0 2.8 7.4 0.0 3.2 3 1 1 4 4 4 0 Tti2 family Adaptin_N PF01602.20 EGD99201.1 - 0.035 12.7 0.5 8.8 4.8 0.0 3.2 3 1 0 3 3 3 0 Adaptin N terminal region Cohesin_HEAT PF12765.7 EGD99201.1 - 0.1 12.9 0.0 0.54 10.6 0.0 2.4 1 0 0 1 1 1 0 HEAT repeat associated with sister chromatid cohesion NPC1_N PF16414.5 EGD99202.1 - 1.9e-83 279.8 6.9 2.7e-83 279.3 6.9 1.2 1 0 0 1 1 1 1 Niemann-Pick C1 N terminus Patched PF02460.18 EGD99202.1 - 1.4e-73 248.4 9.1 9.3e-73 245.6 9.1 2.0 1 1 0 1 1 1 1 Patched family Sterol-sensing PF12349.8 EGD99202.1 - 4.2e-53 179.3 5.8 4.2e-53 179.3 5.8 3.2 3 1 0 3 3 3 1 Sterol-sensing domain of SREBP cleavage-activation MMPL PF03176.15 EGD99202.1 - 2.5e-07 30.0 8.1 2.5e-07 30.0 8.1 3.6 4 1 0 4 4 4 1 MMPL family Folate_rec PF03024.14 EGD99202.1 - 0.00018 21.4 2.6 0.00038 20.4 2.6 1.5 1 0 0 1 1 1 1 Folate receptor family DUF2433 PF10360.9 EGD99203.1 - 1.2e-48 164.3 0.0 2.1e-48 163.5 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2433) Metallophos PF00149.28 EGD99203.1 - 0.00074 20.1 0.0 0.0017 18.9 0.0 1.6 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EGD99203.1 - 0.0011 19.2 0.0 0.0041 17.3 0.0 1.9 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain TFIIA PF03153.13 EGD99203.1 - 0.4 10.6 10.8 0.69 9.8 10.8 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PAP1 PF08601.10 EGD99204.1 - 1.9e-89 301.0 49.7 1.7e-86 291.3 40.3 4.1 1 1 1 2 2 2 1 Transcription factor PAP1 bZIP_1 PF00170.21 EGD99204.1 - 5.1e-08 32.9 9.1 1.1e-07 31.8 9.1 1.5 1 0 0 1 1 1 1 bZIP transcription factor SlyX PF04102.12 EGD99204.1 - 0.00062 20.3 0.3 0.0014 19.2 0.3 1.6 1 0 0 1 1 1 1 SlyX DUF16 PF01519.16 EGD99204.1 - 0.0068 16.9 1.1 0.013 16.0 1.1 1.4 1 0 0 1 1 1 1 Protein of unknown function DUF16 COG7 PF10191.9 EGD99204.1 - 0.055 11.7 0.1 0.084 11.1 0.1 1.2 1 0 0 1 1 1 0 Golgi complex component 7 (COG7) SHE3 PF17078.5 EGD99204.1 - 0.11 12.1 3.1 0.19 11.4 3.1 1.2 1 0 0 1 1 1 0 SWI5-dependent HO expression protein 3 bZIP_Maf PF03131.17 EGD99204.1 - 0.18 12.4 10.1 0.44 11.1 10.1 1.7 1 0 0 1 1 1 0 bZIP Maf transcription factor TSC22 PF01166.18 EGD99204.1 - 0.27 11.6 0.9 0.59 10.5 0.9 1.5 1 0 0 1 1 1 0 TSC-22/dip/bun family Tudor_3 PF18115.1 EGD99205.1 - 2e-07 30.7 0.0 3.5e-07 30.0 0.0 1.4 1 0 0 1 1 1 1 DNA repair protein Crb2 Tudor domain DUF4537 PF15057.6 EGD99205.1 - 0.0041 17.1 0.0 0.0072 16.3 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4537) Tudor_2 PF18104.1 EGD99205.1 - 0.17 11.6 0.0 0.39 10.4 0.0 1.6 1 0 0 1 1 1 0 Jumonji domain-containing protein 2A Tudor domain TRAUB PF08164.12 EGD99206.1 - 1.7e-30 105.3 1.1 4.3e-30 104.1 0.0 2.3 2 0 0 2 2 2 1 Apoptosis-antagonizing transcription factor, C-terminal AATF-Che1 PF13339.6 EGD99206.1 - 1.2e-26 94.0 0.9 1.2e-26 94.0 0.9 2.7 3 1 0 3 3 3 1 Apoptosis antagonizing transcription factor KfrA_N PF11740.8 EGD99206.1 - 0.11 13.1 0.1 0.11 13.1 0.1 2.1 2 0 0 2 2 2 0 Plasmid replication region DNA-binding N-term ParA PF10609.9 EGD99207.1 - 2e-77 260.0 0.0 1.7e-75 253.7 0.0 2.8 1 1 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 EGD99207.1 - 6.4e-08 32.7 0.0 1.5e-06 28.3 0.0 2.3 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 EGD99207.1 - 7.1e-06 26.1 0.1 0.00068 19.6 0.1 2.1 2 0 0 2 2 2 1 AAA domain MipZ PF09140.11 EGD99207.1 - 0.014 14.7 0.0 0.023 14.0 0.0 1.3 1 0 0 1 1 1 0 ATPase MipZ ArsA_ATPase PF02374.15 EGD99207.1 - 0.17 11.1 0.2 4.3 6.4 0.2 2.5 2 1 1 3 3 3 0 Anion-transporting ATPase DUF2614 PF11023.8 EGD99207.1 - 0.2 11.8 0.0 0.35 11.0 0.0 1.3 1 0 0 1 1 1 0 Zinc-ribbon containing domain Abhydrolase_3 PF07859.13 EGD99208.1 - 7.7e-34 117.4 0.0 1.1e-24 87.5 0.0 2.3 2 0 0 2 2 2 2 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 EGD99208.1 - 4.1e-15 55.5 0.0 1.1e-14 54.1 0.0 1.6 1 1 0 1 1 1 1 Steryl acetyl hydrolase IHABP4_N PF16174.5 EGD99208.1 - 2.4 8.7 6.7 3.3 8.3 4.1 2.2 2 0 0 2 2 2 0 Intracellular hyaluronan-binding protein 4 N-terminal WGG PF10273.9 EGD99209.1 - 1.8e-28 99.0 0.1 3.4e-28 98.1 0.1 1.5 1 0 0 1 1 1 1 Pre-rRNA-processing protein TSR2 RRP7 PF12923.7 EGD99209.1 - 0.052 13.7 0.3 0.14 12.3 0.1 1.8 2 0 0 2 2 2 0 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain NOA36 PF06524.12 EGD99209.1 - 0.33 10.2 6.5 0.43 9.9 6.5 1.1 1 0 0 1 1 1 0 NOA36 protein CDC45 PF02724.14 EGD99209.1 - 0.97 7.6 8.2 1.1 7.5 8.2 1.0 1 0 0 1 1 1 0 CDC45-like protein Tht1 PF04163.12 EGD99210.1 - 1.1e-07 31.1 10.3 1.5e-07 30.6 3.9 2.8 2 1 1 3 3 3 1 Tht1-like nuclear fusion protein ApoLp-III PF07464.11 EGD99210.1 - 0.0062 16.6 7.5 0.0071 16.4 1.6 3.2 2 1 0 3 3 3 1 Apolipophorin-III precursor (apoLp-III) Spore_IV_A PF09547.10 EGD99210.1 - 0.012 14.6 0.4 0.018 14.0 0.4 1.3 1 0 0 1 1 1 0 Stage IV sporulation protein A (spore_IV_A) DUF885 PF05960.11 EGD99210.1 - 0.029 14.0 1.0 0.044 13.4 1.0 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF885) TFIID_20kDa PF03847.13 EGD99210.1 - 0.06 13.8 0.0 2 9.0 0.0 2.8 2 1 0 2 2 2 0 Transcription initiation factor TFIID subunit A Baculo_PEP_C PF04513.12 EGD99210.1 - 0.85 9.7 15.1 1.6 8.7 2.0 3.0 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Syntaxin_2 PF14523.6 EGD99210.1 - 0.89 10.0 17.4 4.5 7.7 0.9 3.5 2 1 1 3 3 3 0 Syntaxin-like protein Peptidase_U4 PF03419.13 EGD99210.1 - 1.3 8.2 8.8 2.1 7.6 8.8 1.2 1 0 0 1 1 1 0 Sporulation factor SpoIIGA BLOC1_2 PF10046.9 EGD99210.1 - 2.7 8.3 7.0 21 5.5 0.3 3.6 2 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Ribosomal_L6 PF00347.23 EGD99211.1 - 3.9e-20 72.3 0.0 1.8e-09 38.1 0.0 2.5 2 1 0 2 2 2 2 Ribosomal protein L6 Inositol_P PF00459.25 EGD99212.1 - 1.9e-51 175.2 0.4 4.6e-51 173.9 0.4 1.5 1 1 0 1 1 1 1 Inositol monophosphatase family VHS PF00790.19 EGD99213.1 - 2.7e-26 92.1 0.0 5.1e-26 91.2 0.0 1.4 1 0 0 1 1 1 1 VHS domain ENTH PF01417.20 EGD99213.1 - 0.00016 21.7 0.1 0.00099 19.2 0.0 2.1 2 0 0 2 2 2 1 ENTH domain Swm2 PF17083.5 EGD99213.1 - 0.023 14.7 0.1 0.11 12.5 0.0 2.1 2 1 0 2 2 2 0 Nucleolar protein Swm2 GAT PF03127.14 EGD99213.1 - 0.045 14.1 0.4 0.13 12.5 0.4 1.9 1 0 0 1 1 1 0 GAT domain RPN7 PF10602.9 EGD99213.1 - 0.05 13.3 1.4 0.093 12.4 1.4 1.4 1 0 0 1 1 1 0 26S proteasome subunit RPN7 CCDC106 PF15794.5 EGD99213.1 - 5.6 6.6 10.6 1.1 8.9 5.2 2.2 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 106 adh_short_C2 PF13561.6 EGD99214.1 - 5.8e-34 117.7 0.6 2.5e-32 112.3 0.6 2.5 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EGD99214.1 - 2.5e-25 89.1 2.9 1.1e-20 74.0 0.0 2.7 1 1 1 2 2 2 2 short chain dehydrogenase FHA PF00498.26 EGD99214.1 - 0.066 13.6 0.0 0.13 12.7 0.0 1.5 1 0 0 1 1 1 0 FHA domain ADH_zinc_N PF00107.26 EGD99214.1 - 0.073 13.0 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 Zinc-binding dehydrogenase KR PF08659.10 EGD99214.1 - 4.5 7.1 9.5 3.5 7.5 1.8 2.7 2 1 0 2 2 2 0 KR domain Hva1_TUDOR PF11160.8 EGD99215.1 - 2.6e-19 69.1 0.2 3e-19 68.9 0.2 1.0 1 0 0 1 1 1 1 Hypervirulence associated proteins TUDOR domain CP2 PF04516.15 EGD99217.1 - 3.5e-67 226.1 0.0 5.1e-67 225.5 0.0 1.2 1 0 0 1 1 1 1 CP2 transcription factor DEAD PF00270.29 EGD99218.1 - 3.8e-44 150.6 0.1 8.8e-44 149.3 0.1 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EGD99218.1 - 1.1e-26 93.3 0.0 4.1e-26 91.5 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EGD99218.1 - 5.1e-07 29.8 0.1 1.6e-06 28.2 0.0 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit UTP25 PF06862.12 EGD99218.1 - 2.6e-05 23.2 0.1 0.0014 17.5 0.0 2.4 1 1 1 2 2 2 1 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 AAA_22 PF13401.6 EGD99218.1 - 0.011 16.0 0.6 0.13 12.5 0.1 2.7 2 1 0 2 2 2 0 AAA domain SIKE PF05769.11 EGD99218.1 - 0.097 12.6 2.4 0.59 10.0 0.3 2.6 3 0 0 3 3 3 0 SIKE family DUF2514 PF10721.9 EGD99218.1 - 2 8.5 0.0 2 8.5 0.0 3.2 4 0 0 4 4 4 0 Protein of unknown function (DUF2514) Ank_2 PF12796.7 EGD99219.1 - 2.5e-34 117.7 0.0 8.6e-16 58.3 0.0 4.0 2 1 2 4 4 4 3 Ankyrin repeats (3 copies) Ank PF00023.30 EGD99219.1 - 6.9e-29 99.0 0.0 9.4e-06 25.8 0.0 5.9 5 0 0 5 5 5 4 Ankyrin repeat Ank_3 PF13606.6 EGD99219.1 - 2.6e-27 91.9 0.0 4.9e-05 23.4 0.0 6.0 5 0 0 5 5 5 5 Ankyrin repeat Ank_4 PF13637.6 EGD99219.1 - 4.6e-26 90.8 0.0 2.7e-09 37.4 0.0 4.2 1 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 EGD99219.1 - 3.6e-17 62.2 0.0 0.00065 19.9 0.0 5.5 1 1 4 5 5 5 5 Ankyrin repeats (many copies) NACHT_N PF17100.5 EGD99219.1 - 1.9e-13 50.8 0.1 4.8e-13 49.5 0.1 1.8 1 1 0 1 1 1 1 N-terminal domain of NWD NACHT-NTPase AAA_16 PF13191.6 EGD99219.1 - 1.6e-07 31.9 0.0 5.3e-07 30.2 0.0 1.9 1 0 0 1 1 1 1 AAA ATPase domain NACHT PF05729.12 EGD99219.1 - 6.4e-05 22.9 0.1 0.0002 21.4 0.0 1.9 2 0 0 2 2 2 1 NACHT domain PEGA PF08308.11 EGD99219.1 - 0.014 15.2 0.0 1.3e+02 2.6 0.0 4.3 3 1 1 4 4 4 0 PEGA domain VWA_3_C PF18571.1 EGD99219.1 - 0.027 14.3 3.0 44 4.0 0.1 4.6 5 0 0 5 5 5 0 von Willebrand factor type A C-terminal domain KAP_NTPase PF07693.14 EGD99219.1 - 0.041 13.1 0.0 0.16 11.2 0.0 1.7 1 1 1 2 2 2 0 KAP family P-loop domain FtsJ PF01728.19 EGD99220.1 - 1.7e-64 217.2 0.0 2.1e-64 216.9 0.0 1.1 1 0 0 1 1 1 1 FtsJ-like methyltransferase FAD_binding_1 PF00667.20 EGD99221.1 - 4.7e-54 183.3 0.0 6.8e-54 182.8 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain NAD_binding_1 PF00175.21 EGD99221.1 - 2.8e-09 37.6 0.0 1.1e-08 35.7 0.0 2.0 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain BCAS2 PF05700.11 EGD99224.1 - 0.039 13.7 1.7 0.039 13.7 1.7 1.6 1 1 1 2 2 2 0 Breast carcinoma amplified sequence 2 (BCAS2) SHE3 PF17078.5 EGD99224.1 - 0.044 13.5 2.8 0.053 13.2 2.8 1.1 1 0 0 1 1 1 0 SWI5-dependent HO expression protein 3 RuvC PF02075.17 EGD99224.1 - 0.12 12.2 0.1 0.14 12.0 0.1 1.1 1 0 0 1 1 1 0 Crossover junction endodeoxyribonuclease RuvC Mvb12 PF09452.10 EGD99224.1 - 0.27 11.7 2.2 1.4 9.4 0.1 2.0 1 1 1 2 2 2 0 ESCRT-I subunit Mvb12 Ketoacyl-synt_C PF02801.22 EGD99225.1 - 1.2e-28 99.5 0.1 4.4e-28 97.7 0.0 1.9 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain ketoacyl-synt PF00109.26 EGD99225.1 - 1.2e-18 67.6 0.1 2.2e-18 66.8 0.1 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Beta-lactamase PF00144.24 EGD99225.1 - 4.6e-18 65.5 0.0 1.4e-17 63.9 0.0 1.8 2 0 0 2 2 2 1 Beta-lactamase KAsynt_C_assoc PF16197.5 EGD99225.1 - 1.6e-14 54.3 0.1 6.7e-14 52.3 0.0 2.0 2 0 0 2 2 2 1 Ketoacyl-synthetase C-terminal extension PP-binding PF00550.25 EGD99225.1 - 3.3e-06 27.3 0.2 2.1e-05 24.8 0.1 2.3 2 0 0 2 2 2 1 Phosphopantetheine attachment site Acyl_transf_1 PF00698.21 EGD99225.1 - 2.3e-05 24.1 0.0 3.8e-05 23.4 0.0 1.3 1 0 0 1 1 1 1 Acyl transferase domain Thiolase_N PF00108.23 EGD99225.1 - 0.0014 18.0 0.0 0.0027 17.1 0.0 1.4 1 0 0 1 1 1 1 Thiolase, N-terminal domain ACP_syn_III PF08545.10 EGD99225.1 - 0.11 12.3 0.4 0.39 10.6 0.1 2.0 2 0 0 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III MFS_1 PF07690.16 EGD99226.1 - 9.9e-46 156.3 50.7 8.1e-38 130.2 21.5 2.7 2 1 1 3 3 3 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EGD99226.1 - 5e-17 61.9 12.6 5e-17 61.9 12.6 2.1 2 0 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.13 EGD99226.1 - 3.1e-09 35.8 7.7 3.1e-09 35.8 7.7 2.3 3 0 0 3 3 3 1 Fungal trichothecene efflux pump (TRI12) OATP PF03137.20 EGD99226.1 - 0.62 8.3 16.4 0.034 12.4 1.6 3.0 2 1 1 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family Proteasome PF00227.26 EGD99227.1 - 9.5e-61 204.6 0.1 1.2e-60 204.3 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EGD99227.1 - 2.6e-13 49.3 0.1 8.7e-13 47.7 0.1 1.9 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature DUF5624 PF18538.1 EGD99227.1 - 0.012 15.7 0.3 0.03 14.4 0.1 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF5624) Nitrate_red_gam PF02665.14 EGD99227.1 - 0.023 14.2 0.0 0.033 13.7 0.0 1.1 1 0 0 1 1 1 0 Nitrate reductase gamma subunit FF PF01846.19 EGD99228.1 - 1.9e-11 43.9 7.7 1.5e-09 37.9 0.1 3.7 3 0 0 3 3 3 2 FF domain WW PF00397.26 EGD99228.1 - 1.6e-10 40.9 6.8 3.2e-09 36.7 2.9 2.6 2 0 0 2 2 2 2 WW domain DUF5641 PF18701.1 EGD99228.1 - 0.00053 20.1 1.2 0.0039 17.3 0.7 2.5 2 0 0 2 2 2 1 Family of unknown function (DUF5641) BPL_N PF09825.9 EGD99228.1 - 0.8 8.7 7.5 1 8.4 6.7 1.5 1 1 0 1 1 1 0 Biotin-protein ligase, N terminal PIN_12 PF16289.5 EGD99228.1 - 0.95 9.9 4.7 5.8 7.4 1.1 2.5 1 1 1 2 2 2 0 PIN domain AbiH PF14253.6 EGD99229.1 - 0.04 13.8 0.1 0.049 13.5 0.1 1.2 1 0 0 1 1 1 0 Bacteriophage abortive infection AbiH DASH_Dam1 PF08653.10 EGD99229.1 - 0.17 11.7 0.2 0.28 11.0 0.2 1.3 1 0 0 1 1 1 0 DASH complex subunit Dam1 SPOC PF07744.13 EGD99231.1 - 6.9e-25 87.7 0.0 1.4e-24 86.8 0.0 1.5 1 0 0 1 1 1 1 SPOC domain TFIIS_M PF07500.14 EGD99231.1 - 6.3e-21 75.0 0.0 1.6e-20 73.7 0.0 1.7 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS), central domain PHD PF00628.29 EGD99231.1 - 2.9e-10 39.9 11.1 5.1e-10 39.1 11.1 1.4 1 0 0 1 1 1 1 PHD-finger PHD_3 PF13922.6 EGD99231.1 - 0.011 16.1 1.1 0.059 13.8 1.1 2.3 1 0 0 1 1 1 0 PHD domain of transcriptional enhancer, Asx PHD_2 PF13831.6 EGD99231.1 - 0.02 14.5 4.0 0.035 13.7 4.0 1.4 1 0 0 1 1 1 0 PHD-finger Terminase_GpA PF05876.12 EGD99231.1 - 0.63 8.5 6.0 0.98 7.9 6.0 1.2 1 0 0 1 1 1 0 Phage terminase large subunit (GpA) zinc_ribbon_10 PF10058.9 EGD99231.1 - 1.5 8.6 5.8 2.9 7.7 5.8 1.5 1 0 0 1 1 1 0 Predicted integral membrane zinc-ribbon metal-binding protein Auxin_repressed PF05564.12 EGD99231.1 - 7.6 7.2 15.3 1.1 9.9 1.6 3.7 3 0 0 3 3 3 0 Dormancy/auxin associated protein LUC7 PF03194.15 EGD99232.1 - 2.7e-73 246.7 0.1 3.3e-73 246.4 0.1 1.0 1 0 0 1 1 1 1 LUC7 N_terminus TelA PF05816.11 EGD99232.1 - 0.0042 16.2 0.5 0.0068 15.5 0.5 1.3 1 0 0 1 1 1 1 Toxic anion resistance protein (TelA) DASH_Duo1 PF08651.10 EGD99232.1 - 0.062 13.1 0.1 0.12 12.1 0.1 1.5 1 0 0 1 1 1 0 DASH complex subunit Duo1 DUF3584 PF12128.8 EGD99232.1 - 0.063 10.8 0.1 0.081 10.4 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DUF2130 PF09903.9 EGD99232.1 - 0.086 12.1 0.3 0.15 11.3 0.3 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2130) T4SS PF07996.11 EGD99232.1 - 0.12 12.7 0.1 0.4 11.1 0.0 1.7 1 1 1 2 2 2 0 Type IV secretion system proteins PP_kinase_N PF13089.6 EGD99232.1 - 0.13 12.6 0.1 0.61 10.4 0.0 1.9 1 1 1 2 2 2 0 Polyphosphate kinase N-terminal domain MCPsignal PF00015.21 EGD99232.1 - 0.19 11.5 0.0 0.27 11.1 0.0 1.2 1 0 0 1 1 1 0 Methyl-accepting chemotaxis protein (MCP) signalling domain XhlA PF10779.9 EGD99232.1 - 0.21 11.8 2.5 0.35 11.1 0.6 2.0 2 0 0 2 2 2 0 Haemolysin XhlA GRP PF07172.11 EGD99232.1 - 0.39 11.4 20.0 0.65 10.7 20.0 1.3 1 0 0 1 1 1 0 Glycine rich protein family Gpi16 PF04113.14 EGD99233.1 - 1.1e-231 770.2 0.0 1.3e-231 769.9 0.0 1.0 1 0 0 1 1 1 1 Gpi16 subunit, GPI transamidase component VMA21 PF09446.10 EGD99234.1 - 1.5e-11 44.2 7.2 2e-11 43.8 7.2 1.2 1 0 0 1 1 1 1 VMA21-like domain DUF2406 PF10295.9 EGD99235.1 - 2e-26 92.4 0.1 2e-26 92.4 0.1 3.3 4 0 0 4 4 4 1 Uncharacterised protein (DUF2406) Ribosomal_L35Ae PF01247.18 EGD99236.1 - 4.7e-30 103.6 3.0 4.5e-28 97.3 3.0 2.0 1 1 0 1 1 1 1 Ribosomal protein L35Ae SRF-TF PF00319.18 EGD99237.1 - 1.7e-23 81.8 0.3 2.7e-23 81.2 0.3 1.3 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) DUF1708 PF08101.11 EGD99238.1 - 2.9e-169 563.8 0.0 4.8e-169 563.1 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1708) DUF45 PF01863.17 EGD99238.1 - 0.035 14.1 1.4 0.092 12.8 1.4 1.7 1 0 0 1 1 1 0 Protein of unknown function DUF45 DUF3602 PF12223.8 EGD99239.1 - 3.9e-25 88.2 11.2 1.6e-22 79.9 3.5 2.6 1 1 2 3 3 3 3 Protein of unknown function (DUF3602) GTP1_OBG PF01018.22 EGD99239.1 - 2.2 7.9 12.2 0.81 9.3 0.6 2.7 2 1 1 3 3 3 0 GTP1/OBG YqhR PF11085.8 EGD99243.1 - 0.02 14.8 1.5 0.055 13.4 1.5 1.7 1 0 0 1 1 1 0 Conserved membrane protein YqhR FAD_binding_4 PF01565.23 EGD99244.1 - 3.5e-17 62.5 1.4 5.8e-17 61.7 1.4 1.4 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EGD99244.1 - 0.0043 17.1 0.5 0.01 15.9 0.5 1.6 1 0 0 1 1 1 1 Berberine and berberine like ERG4_ERG24 PF01222.17 EGD99245.1 - 8.6e-146 486.1 16.4 1e-145 485.8 16.4 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family GTP1_OBG PF01018.22 EGD99246.1 - 5.9e-37 126.7 2.0 4.1e-27 94.7 3.3 2.2 2 0 0 2 2 2 2 GTP1/OBG MMR_HSR1 PF01926.23 EGD99246.1 - 1e-22 80.4 0.0 2e-22 79.4 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EGD99246.1 - 7.2e-08 32.1 0.0 1.4e-07 31.2 0.0 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B MeaB PF03308.16 EGD99246.1 - 0.012 14.7 0.0 0.51 9.3 0.0 2.3 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB ABC_tran PF00005.27 EGD99246.1 - 0.099 13.2 2.0 0.15 12.6 0.1 2.2 2 0 0 2 2 2 0 ABC transporter UQ_con PF00179.26 EGD99247.1 - 4.8e-10 39.2 0.0 8.6e-10 38.4 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 EGD99247.1 - 0.14 12.4 0.1 0.28 11.5 0.1 1.5 1 0 0 1 1 1 0 RWD domain DUF5314 PF17241.2 EGD99247.1 - 0.24 11.1 0.0 0.45 10.1 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5314) 2OG-FeII_Oxy_2 PF13532.6 EGD99249.1 - 4.2e-36 125.0 0.2 7.1e-36 124.2 0.2 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily CUE PF02845.16 EGD99249.1 - 4.5e-06 26.2 0.0 1e-05 25.1 0.0 1.5 1 0 0 1 1 1 1 CUE domain zf-GRF PF06839.12 EGD99249.1 - 0.00019 21.4 7.9 0.0004 20.4 7.9 1.5 1 0 0 1 1 1 1 GRF zinc finger POTRA_3 PF17287.2 EGD99249.1 - 0.12 11.8 0.0 8.1 6.0 0.0 2.4 2 0 0 2 2 2 0 POTRA domain Cupin_8 PF13621.6 EGD99250.1 - 1.1e-32 113.8 0.0 2.2e-32 112.7 0.0 1.5 1 1 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.12 EGD99250.1 - 1.5e-06 27.9 0.0 0.0011 18.6 0.0 2.4 2 0 0 2 2 2 2 Cupin superfamily protein JmjC PF02373.22 EGD99250.1 - 0.01 16.3 0.0 0.026 14.9 0.0 1.8 1 0 0 1 1 1 0 JmjC domain, hydroxylase Cupin_2 PF07883.11 EGD99250.1 - 0.093 12.5 0.0 0.7 9.7 0.0 2.3 2 0 0 2 2 2 0 Cupin domain Homeobox_KN PF05920.11 EGD99251.1 - 4.4e-16 58.5 0.2 1.1e-15 57.2 0.2 1.8 1 0 0 1 1 1 1 Homeobox KN domain HTH_Tnp_Tc5 PF03221.16 EGD99251.1 - 0.00013 21.9 0.0 0.00065 19.7 0.0 2.1 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain Homeodomain PF00046.29 EGD99251.1 - 0.00021 21.1 0.1 0.00043 20.1 0.1 1.6 1 0 0 1 1 1 1 Homeodomain Fungal_trans PF04082.18 EGD99252.1 - 2.2e-26 92.5 0.0 6.6e-26 90.9 0.0 1.9 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EGD99252.1 - 3.9e-08 33.3 13.3 6.3e-08 32.6 13.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DnaJ PF00226.31 EGD99253.1 - 3.5e-22 78.3 1.1 6.8e-22 77.4 1.1 1.5 1 0 0 1 1 1 1 DnaJ domain Adenylsucc_synt PF00709.21 EGD99254.1 - 1.2e-86 291.3 0.0 1.3e-86 291.2 0.0 1.0 1 0 0 1 1 1 1 Adenylosuccinate synthetase DUF3221 PF11518.8 EGD99254.1 - 0.14 12.5 0.0 0.31 11.4 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3221) Ank_2 PF12796.7 EGD99255.1 - 9.4e-31 106.3 20.8 1.2e-06 28.9 0.0 12.4 8 4 3 12 12 12 8 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EGD99255.1 - 1.4e-21 76.6 19.1 0.014 15.9 0.0 14.2 11 2 2 13 13 13 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 EGD99255.1 - 1.3e-13 50.9 2.8 0.3 11.5 0.0 9.9 10 1 1 11 11 11 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EGD99255.1 - 3.3e-13 48.5 13.3 11 7.0 0.0 16.2 20 0 0 20 20 20 2 Ankyrin repeat Ank PF00023.30 EGD99255.1 - 1.6e-07 31.4 34.7 3.7 8.2 0.0 15.1 19 2 1 20 20 20 2 Ankyrin repeat Polysacc_deac_1 PF01522.21 EGD99255.1 - 0.057 13.3 0.1 0.85 9.5 0.1 2.7 3 0 0 3 3 3 0 Polysaccharide deacetylase NigD_C PF17415.2 EGD99255.1 - 0.13 12.4 0.0 0.49 10.5 0.0 2.0 1 0 0 1 1 1 0 NigD-like C-terminal beta sandwich domain DEAD PF00270.29 EGD99256.1 - 3.7e-43 147.3 0.0 5.5e-43 146.8 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EGD99256.1 - 9.1e-19 67.8 0.2 4.6e-18 65.6 0.1 2.2 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EGD99256.1 - 8.5e-05 22.6 0.0 0.00014 21.9 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit RIP PF00161.19 EGD99256.1 - 0.093 12.3 0.0 0.19 11.3 0.0 1.4 1 0 0 1 1 1 0 Ribosome inactivating protein Aldolase_II PF00596.21 EGD99257.1 - 4.1e-46 157.3 0.1 5.2e-46 156.9 0.1 1.1 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain PLAC8 PF04749.17 EGD99258.1 - 1.3e-16 61.4 11.3 1.6e-16 61.1 11.3 1.1 1 0 0 1 1 1 1 PLAC8 family Abhydrolase_3 PF07859.13 EGD99260.1 - 4e-33 115.1 0.0 9e-33 113.9 0.0 1.5 1 1 1 2 2 2 1 alpha/beta hydrolase fold Thioesterase PF00975.20 EGD99260.1 - 0.045 13.9 0.1 0.067 13.3 0.1 1.6 1 1 0 1 1 1 0 Thioesterase domain Methyltr_RsmB-F PF01189.17 EGD99261.1 - 1.6e-30 106.2 0.0 1.7e-22 80.1 0.0 3.3 2 1 0 2 2 2 2 16S rRNA methyltransferase RsmB/F Ubie_methyltran PF01209.18 EGD99261.1 - 0.22 10.9 0.0 0.86 8.9 0.0 1.8 2 0 0 2 2 2 0 ubiE/COQ5 methyltransferase family ECF_trnsprt PF12822.7 EGD99262.1 - 0.025 14.7 0.0 0.03 14.4 0.0 1.1 1 0 0 1 1 1 0 ECF transporter, substrate-specific component Syndecan PF01034.20 EGD99262.1 - 0.44 10.5 2.0 0.44 10.5 0.2 1.8 2 0 0 2 2 2 0 Syndecan domain DUF2968 PF11180.8 EGD99264.1 - 0.0002 21.0 8.5 0.0002 21.0 8.5 4.4 3 1 1 4 4 4 2 Protein of unknown function (DUF2968) Fib_alpha PF08702.10 EGD99264.1 - 0.0052 17.0 4.7 0.0052 17.0 4.7 4.6 2 1 2 4 4 4 2 Fibrinogen alpha/beta chain family DUF4363 PF14276.6 EGD99264.1 - 0.0061 16.7 5.2 0.0061 16.7 5.2 4.3 3 2 1 5 5 5 1 Domain of unknown function (DUF4363) APG6_N PF17675.1 EGD99264.1 - 0.019 15.5 18.0 0.019 15.5 18.0 4.6 2 1 1 4 4 4 0 Apg6 coiled-coil region Helicase_IV_N PF12462.8 EGD99264.1 - 0.029 14.3 0.3 0.029 14.3 0.3 3.2 3 1 0 3 3 3 0 DNA helicase IV / RNA helicase N terminal Spectrin PF00435.21 EGD99264.1 - 0.19 12.2 34.0 0.035 14.6 9.0 3.7 3 1 0 3 3 3 0 Spectrin repeat DUF1664 PF07889.12 EGD99264.1 - 2.5 8.1 21.9 0.98 9.5 3.1 4.1 2 1 3 5 5 5 0 Protein of unknown function (DUF1664) PhoU PF01895.19 EGD99264.1 - 2.8 8.5 12.4 4 8.0 1.9 3.7 2 1 1 3 3 3 0 PhoU domain Baculo_PEP_C PF04513.12 EGD99264.1 - 8.6 6.4 16.3 1.6 8.8 3.4 3.5 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus RNA_pol_Rpb5_C PF01191.19 EGD99265.1 - 9.3e-30 102.3 0.1 1.6e-29 101.5 0.1 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb5, C-terminal domain RNA_pol_Rpb5_N PF03871.14 EGD99265.1 - 3.5e-26 91.6 0.0 5.6e-26 91.0 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb5, N-terminal domain Mrr_cat PF04471.12 EGD99265.1 - 0.00035 20.6 0.0 0.00085 19.3 0.0 1.6 2 0 0 2 2 2 1 Restriction endonuclease AMP-binding PF00501.28 EGD99267.1 - 2.4e-42 145.0 0.0 3.6e-42 144.4 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EGD99267.1 - 0.0012 19.8 0.0 0.0025 18.8 0.0 1.5 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain zf-C2H2_jaz PF12171.8 EGD99268.1 - 2e-08 34.3 0.4 4e-08 33.4 0.4 1.5 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EGD99268.1 - 9.3e-06 25.9 0.5 9.3e-06 25.9 0.5 1.8 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2 PF00096.26 EGD99268.1 - 0.0008 19.7 0.4 0.0016 18.8 0.4 1.6 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_2 PF12756.7 EGD99268.1 - 0.12 12.7 0.0 0.29 11.5 0.0 1.6 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) BIR PF00653.21 EGD99269.1 - 1.5e-43 147.2 8.7 4.5e-21 75.3 0.2 2.6 2 0 0 2 2 2 2 Inhibitor of Apoptosis domain Tam41_Mmp37 PF09139.11 EGD99270.1 - 6.7e-132 439.8 0.0 8.3e-132 439.5 0.0 1.1 1 0 0 1 1 1 1 Phosphatidate cytidylyltransferase, mitochondrial Aminotran_1_2 PF00155.21 EGD99272.1 - 3.5e-63 214.0 0.0 4.1e-63 213.7 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 EGD99272.1 - 0.032 13.2 0.0 0.048 12.6 0.0 1.2 1 0 0 1 1 1 0 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 EGD99272.1 - 0.048 12.2 0.2 0.088 11.3 0.0 1.4 2 0 0 2 2 2 0 Cys/Met metabolism PLP-dependent enzyme TFIID-18kDa PF02269.16 EGD99273.1 - 2.1e-30 104.6 0.4 2.3e-29 101.2 0.4 2.3 2 0 0 2 2 2 1 Transcription initiation factor IID, 18kD subunit TP_methylase PF00590.20 EGD99274.1 - 4.7e-23 82.2 0.2 7.4e-23 81.6 0.2 1.3 1 0 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases Orbi_NS1 PF01718.16 EGD99275.1 - 0.028 12.9 0.0 0.037 12.5 0.0 1.1 1 0 0 1 1 1 0 Orbivirus non-structural protein NS1, or hydrophobic tubular protein Clat_adaptor_s PF01217.20 EGD99276.1 - 2e-54 183.4 2.3 2.4e-54 183.1 2.3 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain AMP-binding PF00501.28 EGD99277.1 - 2.3e-57 194.5 0.0 2.7e-57 194.3 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EGD99277.1 - 0.0031 18.4 0.0 0.0078 17.2 0.0 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain DAHP_synth_2 PF01474.16 EGD99279.1 - 1.8e-71 241.0 0.3 4.9e-48 163.7 0.1 2.0 2 0 0 2 2 2 2 Class-II DAHP synthetase family Peptidase_S28 PF05577.12 EGD99280.1 - 4.5e-56 190.5 0.5 7.6e-56 189.7 0.5 1.3 1 0 0 1 1 1 1 Serine carboxypeptidase S28 SfLAP PF11139.8 EGD99281.1 - 0.0034 16.9 0.1 0.0034 16.9 0.1 1.7 2 0 0 2 2 2 1 Sap, sulfolipid-1-addressing protein Ist1 PF03398.14 EGD99282.1 - 6.1e-27 94.5 0.6 1.5e-14 54.2 1.8 2.1 2 0 0 2 2 2 2 Regulator of Vps4 activity in the MVB pathway zf-C3HC4 PF00097.25 EGD99283.1 - 1.2e-08 34.7 8.3 2.4e-07 30.5 8.3 2.6 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EGD99283.1 - 4.7e-07 29.6 4.1 1.9e-06 27.7 4.1 2.1 1 1 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 EGD99283.1 - 1.1e-06 28.4 7.0 0.00026 20.8 2.9 2.7 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EGD99283.1 - 5.4e-06 26.3 2.6 5.4e-06 26.3 2.6 2.3 2 0 0 2 2 2 1 RING-type zinc-finger zf-CCCH_4 PF18044.1 EGD99283.1 - 5.9e-05 22.8 19.4 0.011 15.6 2.5 3.5 3 0 0 3 3 3 2 CCCH-type zinc finger zf-C3HC4_2 PF13923.6 EGD99283.1 - 6.4e-05 22.7 10.1 0.00012 21.8 4.2 2.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EGD99283.1 - 0.00013 22.3 5.4 0.00013 22.3 5.4 3.2 4 0 0 4 4 2 1 Ring finger domain zf-CCCH PF00642.24 EGD99283.1 - 0.0029 17.5 16.0 0.023 14.6 1.5 3.4 3 0 0 3 3 3 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Prok-RING_4 PF14447.6 EGD99283.1 - 0.0035 17.2 8.2 0.26 11.2 3.6 2.6 2 0 0 2 2 2 2 Prokaryotic RING finger family 4 Torus PF16131.5 EGD99283.1 - 0.0088 16.7 6.8 0.18 12.5 0.1 3.4 2 1 0 3 3 3 1 Torus domain YyzF PF14116.6 EGD99283.1 - 0.013 15.5 0.3 1.9 8.6 0.0 2.7 2 0 0 2 2 2 0 YyzF-like protein zf-C3HC4_4 PF15227.6 EGD99283.1 - 0.019 15.1 2.7 0.019 15.1 2.7 2.7 2 1 0 2 2 2 0 zinc finger of C3HC4-type, RING Zn_ribbon_17 PF17120.5 EGD99283.1 - 0.02 14.5 1.3 0.02 14.5 1.3 2.5 3 0 0 3 3 3 0 Zinc-ribbon, C4HC2 type zf-ANAPC11 PF12861.7 EGD99283.1 - 0.037 14.1 1.4 1.7 8.8 0.4 2.8 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.7 EGD99283.1 - 0.052 13.8 11.4 0.63 10.4 6.0 2.9 2 1 0 2 2 2 0 RING-H2 zinc finger domain zf-CCCH_3 PF15663.5 EGD99283.1 - 0.11 12.7 3.9 0.25 11.6 0.2 3.0 4 0 0 4 4 3 0 Zinc-finger containing family zf-CCCH_2 PF14608.6 EGD99283.1 - 0.2 12.2 20.0 1.2 9.7 3.6 3.6 3 0 0 3 3 3 0 RNA-binding, Nab2-type zinc finger zf-RING_6 PF14835.6 EGD99283.1 - 0.56 10.1 5.2 0.25 11.2 2.0 2.0 2 0 0 2 2 2 0 zf-RING of BARD1-type protein DUF1180 PF06679.12 EGD99283.1 - 8.3 6.8 7.7 15 6.0 0.7 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1180) SUN PF03856.13 EGD99284.1 - 2.2e-78 263.1 10.7 3.2e-78 262.6 10.7 1.2 1 0 0 1 1 1 1 Beta-glucosidase (SUN family) Apt1 PF10351.9 EGD99284.1 - 0.98 8.2 12.6 1.3 7.8 12.6 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain SOG2 PF10428.9 EGD99284.1 - 3.8 6.6 21.2 5.4 6.1 21.2 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein Ndc1_Nup PF09531.10 EGD99284.1 - 8.7 4.9 13.2 12 4.5 13.2 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup LCM PF04072.14 EGD99285.1 - 5.4e-24 85.2 0.0 1.2e-23 84.0 0.0 1.6 1 1 0 1 1 1 1 Leucine carboxyl methyltransferase zf-RING_2 PF13639.6 EGD99286.1 - 1.6e-07 31.5 11.7 3.7e-07 30.4 11.7 1.7 1 0 0 1 1 1 1 Ring finger domain zf-ANAPC11 PF12861.7 EGD99286.1 - 0.00022 21.2 4.1 0.00051 20.0 4.1 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Xpo1 PF08389.12 EGD99286.1 - 0.00032 20.8 10.6 0.25 11.4 0.4 4.4 4 0 0 4 4 4 2 Exportin 1-like protein zf-rbx1 PF12678.7 EGD99286.1 - 0.00034 20.8 10.6 0.001 19.3 10.6 1.8 1 1 0 1 1 1 1 RING-H2 zinc finger domain FANCL_C PF11793.8 EGD99286.1 - 0.0014 18.7 6.9 0.0032 17.6 6.9 1.6 1 0 0 1 1 1 1 FANCL C-terminal domain zf-C3HC4_2 PF13923.6 EGD99286.1 - 0.0043 16.9 11.1 0.012 15.5 11.1 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EGD99286.1 - 0.0052 16.6 13.0 0.011 15.6 13.0 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 EGD99286.1 - 0.018 14.7 6.7 0.043 13.4 6.7 1.6 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-RING-like PF08746.11 EGD99286.1 - 0.2 12.0 10.1 0.54 10.6 10.1 1.8 1 0 0 1 1 1 0 RING-like domain C1_1 PF00130.22 EGD99286.1 - 1.1 9.2 8.6 0.4 10.6 5.6 1.7 1 1 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) RINGv PF12906.7 EGD99286.1 - 1.6 8.9 10.1 3.4 7.9 10.1 1.6 1 0 0 1 1 1 0 RING-variant domain zf-Nse PF11789.8 EGD99286.1 - 4.6 7.1 5.5 12 5.8 5.5 1.7 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-C3HC4_3 PF13920.6 EGD99286.1 - 7.4 6.5 7.8 19 5.2 7.8 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DEAD_2 PF06733.15 EGD99287.1 - 3.7e-56 189.5 0.1 7.9e-56 188.4 0.1 1.6 1 0 0 1 1 1 1 DEAD_2 HBB PF06777.11 EGD99287.1 - 8.3e-48 162.6 1.9 1.3e-42 145.6 0.6 2.5 2 0 0 2 2 2 2 Helical and beta-bridge domain Helicase_C_2 PF13307.6 EGD99287.1 - 5.1e-44 150.4 0.0 1.5e-43 148.9 0.0 1.8 1 0 0 1 1 1 1 Helicase C-terminal domain ResIII PF04851.15 EGD99287.1 - 6.1e-06 26.3 0.0 0.00093 19.2 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EGD99287.1 - 0.00039 20.2 0.0 0.11 12.2 0.0 2.4 2 0 0 2 2 2 2 DEAD/DEAH box helicase SNF2_N PF00176.23 EGD99287.1 - 0.007 15.1 0.1 0.19 10.4 0.1 2.3 1 1 0 1 1 1 1 SNF2 family N-terminal domain AAA_22 PF13401.6 EGD99287.1 - 0.07 13.4 2.2 12 6.2 0.0 3.3 3 0 0 3 3 3 0 AAA domain AAA_19 PF13245.6 EGD99287.1 - 0.15 12.4 0.0 0.61 10.4 0.0 2.0 1 1 0 1 1 1 0 AAA domain AAA_11 PF13086.6 EGD99287.1 - 2.9 7.6 5.1 0.93 9.2 0.3 2.4 2 1 0 2 2 2 0 AAA domain RNA_pol_Rpb1_5 PF04998.17 EGD99288.1 - 1.5e-87 293.5 0.0 2.4e-87 292.7 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 EGD99288.1 - 7.2e-67 224.7 0.1 1.5e-66 223.7 0.1 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.18 EGD99288.1 - 1.7e-34 119.0 0.0 6.2e-33 113.9 0.0 2.8 3 0 0 3 3 3 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_1 PF04997.12 EGD99288.1 - 3.1e-27 95.7 3.2 6.7e-26 91.4 3.1 3.0 2 1 0 2 2 2 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_4 PF05000.17 EGD99288.1 - 2e-17 63.1 0.0 7.4e-17 61.3 0.0 2.0 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 PRP3 PF08572.10 EGD99289.1 - 1.8e-74 250.2 2.9 2.9e-74 249.6 2.9 1.3 1 0 0 1 1 1 1 pre-mRNA processing factor 3 (PRP3) DUF1115 PF06544.12 EGD99289.1 - 2.7e-48 163.8 0.5 2.7e-48 163.8 0.5 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF1115) GET2 PF08690.10 EGD99289.1 - 9.9 5.7 9.8 1.4 8.5 4.8 2.1 2 0 0 2 2 2 0 GET complex subunit GET2 Zn_clus PF00172.18 EGD99290.1 - 1.5e-06 28.2 10.5 2.3e-06 27.6 10.5 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EGD99290.1 - 7.2e-05 21.9 0.1 0.00019 20.5 0.1 1.7 1 0 0 1 1 1 1 Fungal specific transcription factor domain ERCC4 PF02732.15 EGD99291.1 - 1.4e-25 90.3 0.0 2.4e-25 89.5 0.0 1.4 1 0 0 1 1 1 1 ERCC4 domain HHH_8 PF14716.6 EGD99291.1 - 0.0071 16.7 0.1 0.83 10.1 0.0 2.6 2 0 0 2 2 2 2 Helix-hairpin-helix domain E1-E2_ATPase PF00122.20 EGD99292.1 - 1.6e-50 171.2 0.1 5.2e-50 169.5 0.0 1.9 2 0 0 2 2 2 1 E1-E2 ATPase HMA PF00403.26 EGD99292.1 - 3.3e-37 126.7 3.8 7e-11 42.4 0.2 4.6 4 0 0 4 4 4 4 Heavy-metal-associated domain Hydrolase PF00702.26 EGD99292.1 - 2.2e-33 116.3 0.2 3.9e-33 115.5 0.2 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 EGD99292.1 - 3.6e-05 23.6 1.1 0.00099 18.9 0.2 2.3 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 EGD99292.1 - 0.015 15.7 0.0 0.034 14.6 0.0 1.6 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase Borrelia_REV PF03978.13 EGD99292.1 - 0.048 13.6 0.0 0.1 12.5 0.0 1.5 1 0 0 1 1 1 0 Borrelia burgdorferi REV protein Equine_IAV_S2 PF06502.11 EGD99293.1 - 0.057 13.5 0.0 0.1 12.7 0.0 1.4 1 0 0 1 1 1 0 Equine infectious anaemia virus S2 protein TFIIB PF00382.19 EGD99294.1 - 1.3e-30 105.2 0.4 4.2e-17 62.0 0.1 2.4 2 0 0 2 2 2 2 Transcription factor TFIIB repeat BRF1 PF07741.13 EGD99294.1 - 1.4e-25 89.5 1.1 5.4e-25 87.7 0.0 2.7 2 0 0 2 2 2 1 Brf1-like TBP-binding domain TF_Zn_Ribbon PF08271.12 EGD99294.1 - 0.00012 21.5 2.7 0.00028 20.3 2.7 1.6 1 0 0 1 1 1 1 TFIIB zinc-binding Cyclin_N PF00134.23 EGD99294.1 - 0.012 15.4 0.1 1.9 8.3 0.0 2.3 2 0 0 2 2 2 0 Cyclin, N-terminal domain zf-RRN7 PF11781.8 EGD99294.1 - 0.32 10.7 1.6 0.7 9.6 0.2 2.1 2 0 0 2 2 2 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 TPT PF03151.16 EGD99296.1 - 7.9e-24 84.5 24.9 1.1e-23 84.1 24.9 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family UAA PF08449.11 EGD99296.1 - 9.7e-05 21.7 24.0 0.00015 21.1 24.0 1.3 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.20 EGD99296.1 - 0.087 13.0 34.9 0.38 10.9 13.1 2.7 3 0 0 3 3 3 0 EamA-like transporter family RNase_H PF00075.24 EGD99299.1 - 1.3e-12 48.1 0.0 1.6e-12 47.8 0.0 1.1 1 0 0 1 1 1 1 RNase H RVT_3 PF13456.6 EGD99299.1 - 9.4e-07 28.7 0.0 0.025 14.4 0.0 2.1 1 1 1 2 2 2 2 Reverse transcriptase-like RNase_H PF00075.24 EGD99300.1 - 1.3e-21 77.3 0.7 1.8e-21 76.8 0.7 1.1 1 0 0 1 1 1 1 RNase H RVT_3 PF13456.6 EGD99300.1 - 8.5e-07 28.8 4.9 0.00014 21.7 4.9 2.6 1 1 0 1 1 1 1 Reverse transcriptase-like RNase_H PF00075.24 EGD99301.1 - 4.1e-17 62.7 0.0 5.4e-17 62.3 0.0 1.1 1 0 0 1 1 1 1 RNase H YyzF PF14116.6 EGD99301.1 - 0.099 12.7 0.0 0.18 11.9 0.0 1.5 1 0 0 1 1 1 0 YyzF-like protein zf_C2H2_13 PF18508.1 EGD99301.1 - 0.35 10.5 1.9 0.41 10.3 0.5 1.8 2 0 0 2 2 2 0 Zinc finger domain Amino_oxidase PF01593.24 EGD99302.1 - 1.3e-08 34.6 0.0 2.5e-08 33.7 0.0 1.4 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EGD99302.1 - 1.1e-07 32.0 0.0 2.3e-07 30.9 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EGD99302.1 - 0.0014 18.0 0.1 0.021 14.0 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EGD99302.1 - 0.0089 15.3 0.1 0.014 14.6 0.1 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EGD99302.1 - 0.014 14.6 0.1 0.033 13.4 0.1 1.5 1 0 0 1 1 1 0 Thi4 family FAD_oxidored PF12831.7 EGD99302.1 - 0.021 14.2 0.0 0.028 13.8 0.0 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 EGD99302.1 - 0.046 13.0 0.1 0.072 12.3 0.1 1.2 1 0 0 1 1 1 0 FAD binding domain TrkA_N PF02254.18 EGD99302.1 - 0.077 13.3 0.0 0.17 12.2 0.0 1.6 1 0 0 1 1 1 0 TrkA-N domain Lycopene_cycl PF05834.12 EGD99302.1 - 0.093 11.8 0.4 0.27 10.3 0.1 1.8 2 0 0 2 2 2 0 Lycopene cyclase protein DAO PF01266.24 EGD99302.1 - 0.14 11.7 0.0 0.25 10.9 0.0 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 EGD99302.1 - 0.22 11.5 0.4 1.1 9.2 0.0 2.3 3 0 0 3 3 3 0 FAD-NAD(P)-binding SR-25 PF10500.9 EGD99304.1 - 5.5e-05 22.9 12.9 0.00011 21.9 12.9 1.5 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein IMUP PF15761.5 EGD99304.1 - 0.39 11.4 7.6 0.89 10.3 7.6 1.6 1 0 0 1 1 1 0 Immortalisation up-regulated protein FAM199X PF15814.5 EGD99304.1 - 1.5 7.8 8.8 2.1 7.3 8.8 1.2 1 0 0 1 1 1 0 Protein family FAM199X Pkinase PF00069.25 EGD99305.1 - 5.2e-65 219.4 0.0 6.6e-65 219.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD99305.1 - 1e-30 106.9 0.0 8e-30 104.0 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EGD99305.1 - 6.8e-05 22.3 0.0 0.00012 21.5 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EGD99305.1 - 0.0022 17.3 0.5 0.042 13.2 0.0 2.6 2 1 0 2 2 2 1 Kinase-like APH PF01636.23 EGD99305.1 - 0.0073 16.3 0.0 0.014 15.3 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EGD99305.1 - 0.013 14.5 0.0 0.02 13.8 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain FTA2 PF13095.6 EGD99305.1 - 0.07 12.7 0.2 3.7 7.1 0.0 2.2 1 1 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 DUF4360 PF14273.6 EGD99306.1 - 1.9e-52 177.7 0.7 2.1e-52 177.6 0.7 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4360) Sugar_tr PF00083.24 EGD99308.1 - 1.3e-102 344.0 23.7 1.6e-102 343.7 23.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EGD99308.1 - 4.4e-20 71.9 31.7 2.1e-14 53.2 6.3 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 EGD99308.1 - 1.2e-05 23.8 1.1 1.2e-05 23.8 1.1 2.5 3 0 0 3 3 3 1 Organic Anion Transporter Polypeptide (OATP) family DUF3464 PF11947.8 EGD99308.1 - 0.002 17.9 3.6 0.0053 16.5 3.6 1.6 1 0 0 1 1 1 1 Photosynthesis affected mutant 68 zf-CCHC PF00098.23 EGD99310.1 - 2e-52 173.0 101.5 1.3e-07 31.4 2.5 11.3 11 0 0 11 11 11 11 Zinc knuckle zf-CCHC_2 PF13696.6 EGD99310.1 - 9.9e-12 44.5 88.2 0.00057 19.6 0.5 11.3 11 0 0 11 11 11 8 Zinc knuckle zf-CCHC_4 PF14392.6 EGD99310.1 - 4.2e-08 32.8 65.0 0.18 11.6 0.2 11.1 11 0 0 11 11 11 7 Zinc knuckle zf-CCHC_3 PF13917.6 EGD99310.1 - 3.6e-06 26.9 78.0 0.048 13.6 0.8 11.1 3 3 8 11 11 11 8 Zinc knuckle zf-CCHC_6 PF15288.6 EGD99310.1 - 0.02 14.7 3.4 0.02 14.7 3.4 10.5 9 2 2 11 11 11 0 Zinc knuckle zf-C2H2_10 PF16588.5 EGD99310.1 - 0.027 14.2 2.8 0.027 14.2 2.8 9.3 10 0 0 10 10 10 0 C2H2 zinc-finger DUF846 PF05832.12 EGD99311.1 - 7.3e-48 162.2 10.0 8.5e-48 161.9 10.0 1.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF846) Acyl-CoA_dh_1 PF00441.24 EGD99312.1 - 3.6e-31 108.4 0.1 5e-31 107.9 0.1 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 EGD99312.1 - 5.8e-24 84.9 0.0 1.3e-23 83.8 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 EGD99312.1 - 1.6e-21 76.3 0.0 2.7e-21 75.5 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 EGD99312.1 - 0.0011 19.2 0.1 0.0016 18.7 0.1 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Bombinin PF05298.11 EGD99312.1 - 0.071 12.8 0.0 0.32 10.7 0.0 2.0 2 0 0 2 2 2 0 Bombinin ECH_1 PF00378.20 EGD99313.1 - 1.9e-47 161.7 0.0 2.4e-47 161.4 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EGD99313.1 - 4.3e-24 85.6 0.1 5.4e-22 78.7 0.0 2.1 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase HpcH_HpaI PF03328.14 EGD99314.1 - 5.1e-43 146.8 0.0 7.5e-43 146.2 0.0 1.2 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family C-C_Bond_Lyase PF15617.6 EGD99314.1 - 5.2e-12 45.6 0.0 8.1e-05 21.9 0.0 2.1 1 1 0 2 2 2 2 C-C_Bond_Lyase of the TIM-Barrel fold Glyco_transf_90 PF05686.12 EGD99316.1 - 6.4e-17 61.5 3.0 1.7e-10 40.4 1.8 2.7 2 1 0 2 2 2 2 Glycosyl transferase family 90 Oxidored_molyb PF00174.19 EGD99318.1 - 2.3e-49 167.3 0.0 3.7e-49 166.6 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase molybdopterin binding domain Mo-co_dimer PF03404.16 EGD99318.1 - 2.8e-37 127.8 0.3 6.1e-37 126.7 0.3 1.6 1 0 0 1 1 1 1 Mo-co oxidoreductase dimerisation domain NAD_binding_1 PF00175.21 EGD99318.1 - 1.5e-26 93.2 0.1 1.2e-25 90.3 0.0 2.6 4 0 0 4 4 4 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 EGD99318.1 - 3.3e-24 85.1 0.0 6.1e-24 84.3 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain Cyt-b5 PF00173.28 EGD99318.1 - 4.5e-16 58.8 0.1 1.4e-15 57.2 0.1 1.9 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain NAD_binding_6 PF08030.12 EGD99318.1 - 0.0022 18.2 0.3 0.16 12.1 0.1 2.9 2 1 0 3 3 3 1 Ferric reductase NAD binding domain CAP59_mtransfer PF11735.8 EGD99319.1 - 4.2e-84 282.0 0.0 5.5e-84 281.6 0.0 1.2 1 0 0 1 1 1 1 Cryptococcal mannosyltransferase 1 Peptidase_S64 PF08192.11 EGD99320.1 - 0.18 10.3 0.0 0.36 9.3 0.0 1.5 2 0 0 2 2 2 0 Peptidase family S64 DUF346 PF03984.13 EGD99321.1 - 1.9e-58 193.9 62.8 3.9e-10 39.3 0.4 7.2 7 0 0 7 7 7 7 Repeat of unknown function (DUF346) Ntox14 PF15522.6 EGD99321.1 - 1.7e-05 24.4 0.0 21 4.4 0.0 6.2 7 0 0 7 7 7 1 Novel toxin 14 DUF1724 PF08350.10 EGD99321.1 - 0.022 14.9 7.4 4 7.6 0.0 4.9 5 0 0 5 5 5 0 Domain of unknown function (DUF1724) Fungal_lectin PF07938.12 EGD99321.1 - 0.11 11.9 17.3 0.19 11.1 0.3 4.4 1 1 3 4 4 4 0 Fungal fucose-specific lectin DUF2510 PF10708.9 EGD99321.1 - 0.17 11.6 48.6 0.33 10.8 2.9 6.4 6 0 0 6 6 6 0 Protein of unknown function (DUF2510) SNARE_assoc PF09335.11 EGD99322.1 - 1.3e-11 45.0 5.1 1.3e-11 45.0 5.1 2.5 2 1 1 3 3 3 1 SNARE associated Golgi protein Amino_oxidase PF01593.24 EGD99323.1 - 5.1e-84 283.1 0.1 8.8e-83 279.1 0.1 2.2 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase SWIRM PF04433.17 EGD99323.1 - 8.3e-14 51.7 0.1 2.6e-13 50.1 0.0 1.9 2 0 0 2 2 2 1 SWIRM domain NAD_binding_8 PF13450.6 EGD99323.1 - 2.8e-07 30.6 0.1 5.9e-07 29.6 0.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain HMG_box PF00505.19 EGD99323.1 - 0.00014 22.2 5.5 0.00014 22.2 2.3 2.5 2 1 0 2 2 2 1 HMG (high mobility group) box DAO PF01266.24 EGD99323.1 - 0.0023 17.6 0.1 0.0052 16.4 0.1 1.6 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EGD99323.1 - 0.0068 15.7 0.1 0.12 11.6 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EGD99324.1 - 5.5e-49 167.0 0.6 6.5e-49 166.7 0.6 1.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EGD99324.1 - 4.1e-17 62.4 0.2 2e-15 56.9 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EGD99324.1 - 4.4e-16 59.2 0.2 2.1e-13 50.6 0.1 2.8 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EGD99324.1 - 2.5e-05 23.6 0.5 6.5e-05 22.3 0.1 1.9 2 0 0 2 2 2 1 Thi4 family NAD_binding_7 PF13241.6 EGD99324.1 - 8e-05 23.0 0.0 0.019 15.4 0.0 2.6 1 1 1 2 2 2 1 Putative NAD(P)-binding NAD_binding_8 PF13450.6 EGD99324.1 - 0.00015 21.9 0.1 0.15 12.3 0.0 2.6 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.6 EGD99324.1 - 0.011 15.0 0.1 0.66 9.1 0.0 3.0 2 1 1 3 3 3 0 L-lysine 6-monooxygenase (NADPH-requiring) FAD_binding_3 PF01494.19 EGD99324.1 - 0.013 14.8 0.4 2.2 7.5 0.0 2.5 2 1 0 2 2 2 0 FAD binding domain DAO PF01266.24 EGD99324.1 - 0.027 14.1 2.3 0.88 9.1 0.1 3.3 2 2 1 3 3 3 0 FAD dependent oxidoreductase Shikimate_DH PF01488.20 EGD99324.1 - 0.075 13.1 0.1 8.5 6.4 0.0 2.9 2 1 1 3 3 3 0 Shikimate / quinate 5-dehydrogenase FAD_binding_2 PF00890.24 EGD99324.1 - 0.14 11.2 5.0 0.39 9.7 0.3 2.8 2 2 2 4 4 4 0 FAD binding domain GIDA PF01134.22 EGD99324.1 - 0.19 10.8 8.0 2.6 7.0 0.3 3.8 3 1 1 5 5 5 0 Glucose inhibited division protein A APH PF01636.23 EGD99326.1 - 2.8e-13 50.3 0.0 4.5e-13 49.7 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EGD99326.1 - 3.3e-10 39.9 0.0 7.8e-10 38.7 0.0 1.5 2 0 0 2 2 2 1 Choline/ethanolamine kinase Pkinase PF00069.25 EGD99326.1 - 0.0069 15.8 0.0 0.17 11.2 0.0 2.0 2 0 0 2 2 2 1 Protein kinase domain Sulfotransfer_4 PF17784.1 EGD99327.1 - 4.3e-64 216.3 0.3 5.3e-64 216.0 0.3 1.1 1 0 0 1 1 1 1 Sulfotransferase domain DUF2116 PF09889.9 EGD99327.1 - 0.0077 16.2 0.8 0.014 15.4 0.8 1.4 1 0 0 1 1 1 1 Uncharacterized protein containing a Zn-ribbon (DUF2116) Sulfotransfer_3 PF13469.6 EGD99327.1 - 0.21 12.0 3.1 2.1 8.7 3.1 2.4 1 1 0 1 1 1 0 Sulfotransferase family p450 PF00067.22 EGD99330.1 - 2.3e-41 142.0 0.0 2.8e-41 141.7 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 EGD99331.1 - 1.1e-43 149.7 0.0 1.2e-43 149.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 SQHop_cyclase_C PF13243.6 EGD99332.1 - 0.01 14.9 0.1 0.58 9.2 0.0 2.8 3 0 0 3 3 3 0 Squalene-hopene cyclase C-terminal domain SQHop_cyclase_N PF13249.6 EGD99332.1 - 0.13 11.3 0.1 0.54 9.3 0.0 2.0 2 0 0 2 2 2 0 Squalene-hopene cyclase N-terminal domain Prenyltrans PF00432.21 EGD99332.1 - 1.4 8.7 3.4 47 3.8 0.1 3.5 3 0 0 3 3 3 0 Prenyltransferase and squalene oxidase repeat p450 PF00067.22 EGD99333.1 - 8.8e-45 153.3 0.0 1.1e-44 152.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 FAD_binding_4 PF01565.23 EGD99335.1 - 1.2e-21 76.9 0.0 2.1e-21 76.1 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EGD99335.1 - 0.0096 16.0 0.0 0.034 14.2 0.0 2.0 1 0 0 1 1 1 1 Berberine and berberine like Na_Ca_ex PF01699.24 EGD99336.1 - 1.5e-28 99.7 32.6 8.9e-15 55.0 12.5 2.1 2 0 0 2 2 2 2 Sodium/calcium exchanger protein DUF2721 PF11026.8 EGD99336.1 - 0.71 9.8 0.0 0.71 9.8 0.0 3.6 3 2 1 4 4 4 0 Protein of unknown function (DUF2721) p450 PF00067.22 EGD99337.1 - 2.8e-26 92.3 0.0 6.3e-18 64.8 0.0 3.0 1 1 1 2 2 2 2 Cytochrome P450 LysM PF01476.20 EGD99339.1 - 5.7e-09 35.9 0.0 9.2e-09 35.2 0.0 1.3 1 0 0 1 1 1 1 LysM domain DUF3176 PF11374.8 EGD99340.1 - 0.46 10.7 4.0 0.15 12.3 0.7 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3176) ADH_zinc_N_2 PF13602.6 EGD99341.1 - 3.4e-13 50.8 0.0 7.6e-13 49.7 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EGD99341.1 - 1.6e-09 37.6 0.1 2.7e-09 36.9 0.1 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EGD99341.1 - 8.3e-08 32.3 0.0 3.6e-07 30.2 0.0 2.0 2 0 0 2 2 2 1 Zinc-binding dehydrogenase DIOX_N PF14226.6 EGD99343.1 - 4e-23 82.4 0.0 7.9e-23 81.5 0.0 1.5 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EGD99343.1 - 2.8e-10 40.6 0.0 5e-10 39.8 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Asp_Glu_race PF01177.22 EGD99344.1 - 3.7e-15 56.4 0.1 5.2e-15 55.9 0.1 1.3 1 0 0 1 1 1 1 Asp/Glu/Hydantoin racemase AroM PF07302.11 EGD99344.1 - 0.00063 19.2 0.0 0.092 12.1 0.1 2.2 1 1 1 2 2 2 2 AroM protein Pantoate_transf PF02548.15 EGD99344.1 - 0.011 15.1 0.3 1 8.7 0.0 2.1 1 1 0 2 2 2 0 Ketopantoate hydroxymethyltransferase ZNRF_3_ecto PF18212.1 EGD99344.1 - 0.15 12.1 0.0 10 6.2 0.0 2.3 2 0 0 2 2 2 0 ZNRF-3 Ectodomain MFS_1 PF07690.16 EGD99345.1 - 5.9e-43 147.1 34.6 2.6e-39 135.2 25.3 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 EGD99345.1 - 0.00043 18.7 12.5 0.0018 16.7 7.9 2.8 2 1 0 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family DIOX_N PF14226.6 EGD99347.1 - 8.9e-20 71.6 0.0 1.4e-19 71.0 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EGD99347.1 - 1.9e-15 57.1 0.0 3.4e-15 56.3 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily ketoacyl-synt PF00109.26 EGD99348.1 - 1.7e-74 250.6 0.0 3e-74 249.8 0.0 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain SAT PF16073.5 EGD99348.1 - 2.1e-50 171.7 0.7 1.2e-46 159.4 0.1 2.6 2 0 0 2 2 2 2 Starter unit:ACP transacylase in aflatoxin biosynthesis Acyl_transf_1 PF00698.21 EGD99348.1 - 6.2e-37 127.8 0.0 6.2e-37 127.8 0.0 2.4 3 0 0 3 3 3 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 EGD99348.1 - 5.9e-34 116.6 0.4 5.9e-34 116.6 0.4 2.4 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain PP-binding PF00550.25 EGD99348.1 - 1.4e-14 54.2 0.1 4.1e-14 52.7 0.1 1.8 1 0 0 1 1 1 1 Phosphopantetheine attachment site KAsynt_C_assoc PF16197.5 EGD99348.1 - 5.1e-11 43.0 0.2 2.2e-10 41.0 0.0 2.2 2 0 0 2 2 2 1 Ketoacyl-synthetase C-terminal extension Thiolase_N PF00108.23 EGD99348.1 - 0.00043 19.7 0.0 0.0011 18.4 0.0 1.6 1 0 0 1 1 1 1 Thiolase, N-terminal domain Trp_DMAT PF11991.8 EGD99349.1 - 6.4e-81 272.6 0.0 8e-81 272.2 0.0 1.1 1 0 0 1 1 1 1 Tryptophan dimethylallyltransferase Orexin PF02072.15 EGD99349.1 - 0.0035 17.3 0.0 0.0062 16.5 0.0 1.3 1 0 0 1 1 1 1 Prepro-orexin DUF4060 PF13269.6 EGD99349.1 - 0.12 12.5 0.1 16 5.6 0.1 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF4060) FAD_binding_3 PF01494.19 EGD99350.1 - 1e-13 51.3 0.4 6.6e-12 45.3 0.4 2.3 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.24 EGD99350.1 - 0.0017 18.0 0.2 0.035 13.7 0.1 2.2 1 1 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EGD99350.1 - 0.0019 18.4 0.0 0.004 17.3 0.0 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EGD99350.1 - 0.11 11.7 0.0 2.9 7.0 0.0 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Lactamase_B PF00753.27 EGD99351.1 - 2.1e-16 60.5 0.9 3.5e-10 40.2 0.2 2.3 1 1 1 2 2 2 2 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EGD99351.1 - 0.00098 18.7 0.1 0.0018 17.9 0.0 1.4 1 1 0 1 1 1 1 Beta-lactamase superfamily domain BLACT_WH PF17778.1 EGD99351.1 - 0.0014 18.6 0.0 0.0054 16.7 0.0 2.1 3 0 0 3 3 3 1 Beta-lactamase associated winged helix domain Zn_clus PF00172.18 EGD99352.1 - 1.5e-07 31.4 7.1 2.8e-07 30.6 7.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EGD99352.1 - 0.00021 20.4 0.2 0.00078 18.5 0.2 1.8 1 1 0 1 1 1 1 Fungal specific transcription factor domain zf-PHD-like PF15446.6 EGD99352.1 - 0.013 15.1 1.6 0.026 14.1 1.6 1.4 1 0 0 1 1 1 0 PHD/FYVE-zinc-finger like domain DUF1840 PF08895.11 EGD99352.1 - 0.099 13.0 0.3 1.5 9.2 0.3 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1840) Metallophos PF00149.28 EGD99353.1 - 7.2e-06 26.6 2.9 1.4e-05 25.7 2.9 1.6 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Peptidase_S21 PF00716.17 EGD99354.1 - 0.019 14.7 0.1 0.026 14.2 0.1 1.1 1 0 0 1 1 1 0 Assemblin (Peptidase family S21) Tyrosinase PF00264.20 EGD99355.1 - 2.7e-49 168.5 2.9 2.7e-49 168.5 2.9 2.0 2 0 0 2 2 2 1 Common central domain of tyrosinase Tyosinase_C PF18132.1 EGD99355.1 - 2.3e-27 96.1 0.0 3.8e-27 95.4 0.0 1.4 1 0 0 1 1 1 1 Tyosinase C-terminal domain Tli4_N PF18443.1 EGD99355.1 - 0.075 13.4 0.3 0.16 12.3 0.3 1.5 1 0 0 1 1 1 0 Tle cognate immunity protein 4 N-terminal domain Fungal_trans PF04082.18 EGD99356.1 - 1.5e-21 76.7 2.9 2.3e-21 76.0 2.9 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Ribosomal_S8e PF01201.22 EGD99357.1 - 1.3e-46 158.2 2.0 1.8e-46 157.7 2.0 1.2 1 0 0 1 1 1 1 Ribosomal protein S8e RIBIOP_C PF04950.12 EGD99357.1 - 0.2 11.1 5.6 0.48 9.8 5.6 1.7 1 1 0 1 1 1 0 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal Ribosomal_L21p PF00829.21 EGD99358.1 - 8.6e-09 35.6 0.0 1.3e-08 35.0 0.0 1.3 1 0 0 1 1 1 1 Ribosomal prokaryotic L21 protein RIB43A PF05914.12 EGD99358.1 - 0.076 11.7 1.0 0.099 11.4 1.0 1.1 1 0 0 1 1 1 0 RIB43A CutA1 PF03091.15 EGD99358.1 - 0.11 12.4 0.2 0.21 11.4 0.2 1.4 1 0 0 1 1 1 0 CutA1 divalent ion tolerance protein Atrophin-1 PF03154.15 EGD99358.1 - 0.18 10.1 5.7 0.24 9.7 5.7 1.1 1 0 0 1 1 1 0 Atrophin-1 family Pkinase PF00069.25 EGD99359.1 - 2.9e-49 167.8 0.0 4.3e-49 167.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD99359.1 - 5.6e-18 65.2 0.0 8.8e-18 64.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.22 EGD99359.1 - 0.00031 20.4 0.1 0.00083 19.0 0.1 1.7 1 1 0 1 1 1 1 RIO1 family APH PF01636.23 EGD99359.1 - 0.00049 20.1 0.0 0.32 10.9 0.0 2.6 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 EGD99359.1 - 0.012 15.0 0.1 0.02 14.2 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EGD99359.1 - 0.033 13.5 0.0 0.057 12.7 0.0 1.3 1 0 0 1 1 1 0 Kinase-like DUF4648 PF15505.6 EGD99359.1 - 0.037 14.9 1.4 11 7.0 0.0 3.9 2 1 1 3 3 3 0 Domain of unknown function (DUF4648) Pkinase_fungal PF17667.1 EGD99359.1 - 0.45 9.2 0.0 0.45 9.2 0.0 2.1 3 0 0 3 3 3 0 Fungal protein kinase PWI PF01480.17 EGD99360.1 - 3.1e-32 110.7 0.1 5.2e-32 110.0 0.1 1.4 1 0 0 1 1 1 1 PWI domain MGC-24 PF05283.11 EGD99361.1 - 0.00028 21.4 0.4 0.00047 20.6 0.4 1.4 1 0 0 1 1 1 1 Multi-glycosylated core protein 24 (MGC-24), sialomucin Phage_HK97_TLTM PF06120.11 EGD99361.1 - 0.036 13.2 0.1 0.049 12.8 0.1 1.1 1 0 0 1 1 1 0 Tail length tape measure protein Podoplanin PF05808.11 EGD99361.1 - 0.068 13.3 0.1 0.099 12.7 0.1 1.3 1 0 0 1 1 1 0 Podoplanin DUF4366 PF14283.6 EGD99361.1 - 0.16 12.0 0.0 0.21 11.6 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) DUF3042 PF11240.8 EGD99361.1 - 0.31 11.1 2.1 0.59 10.2 2.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3042) C8 PF08742.11 EGD99361.1 - 0.89 10.0 5.5 0.34 11.4 1.8 2.1 1 1 1 2 2 2 0 C8 domain MSA-2c PF12238.8 EGD99361.1 - 3.3 7.7 6.2 4.6 7.2 6.2 1.2 1 0 0 1 1 1 0 Merozoite surface antigen 2c FAA_hydrolase PF01557.18 EGD99363.1 - 1.1e-53 182.1 0.0 1.3e-53 181.9 0.0 1.0 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family DUF3584 PF12128.8 EGD99364.1 - 0.013 13.1 6.9 0.018 12.6 6.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Baculo_PEP_C PF04513.12 EGD99364.1 - 0.015 15.3 0.9 0.079 13.0 0.2 2.2 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Nup54_57_C PF18570.1 EGD99364.1 - 0.051 13.2 0.0 0.14 11.8 0.0 1.7 1 0 0 1 1 1 0 NUP57/Nup54 C-terminal domain TSC22 PF01166.18 EGD99364.1 - 0.088 13.1 0.6 1.6 9.1 0.1 2.9 3 0 0 3 3 3 0 TSC-22/dip/bun family TetR_C_24 PF17932.1 EGD99364.1 - 0.089 13.1 1.5 0.18 12.1 1.1 1.7 1 1 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain Mis14 PF08641.12 EGD99364.1 - 0.13 12.6 5.6 0.12 12.6 3.3 2.3 2 1 0 2 2 2 0 Kinetochore protein Mis14 like Snapin_Pallidin PF14712.6 EGD99364.1 - 0.24 11.8 4.7 0.51 10.8 0.2 2.8 2 0 0 2 2 2 0 Snapin/Pallidin DUF883 PF05957.13 EGD99364.1 - 0.47 11.1 2.8 1.1 9.9 0.9 2.2 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) Uso1_p115_C PF04871.13 EGD99364.1 - 1.1 9.7 5.8 6.1 7.2 0.5 2.4 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region Apolipoprotein PF01442.18 EGD99364.1 - 2.2 8.1 13.3 3.3 7.5 10.1 2.2 2 0 0 2 2 2 0 Apolipoprotein A1/A4/E domain DEAD PF00270.29 EGD99365.1 - 7.5e-45 152.8 0.7 1.4e-44 151.9 0.7 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EGD99365.1 - 1.2e-31 109.3 0.3 4.1e-31 107.6 0.1 2.0 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EGD99365.1 - 7.5e-07 29.3 0.0 1.3e-06 28.6 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 EGD99365.1 - 5.6e-05 22.9 0.1 0.00011 22.0 0.1 1.4 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EGD99365.1 - 0.00067 20.0 1.2 0.0046 17.3 0.7 2.2 2 1 0 2 2 2 1 AAA domain AAA_22 PF13401.6 EGD99365.1 - 0.0038 17.5 0.4 0.019 15.2 0.4 2.2 1 1 0 1 1 1 1 AAA domain CMS1 PF14617.6 EGD99365.1 - 0.011 15.1 0.0 0.023 14.0 0.0 1.5 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit Helicase_RecD PF05127.14 EGD99365.1 - 0.068 13.0 0.0 0.14 12.0 0.0 1.6 1 0 0 1 1 1 0 Helicase fragilysinNterm PF16376.5 EGD99365.1 - 0.095 12.4 0.0 0.32 10.7 0.0 1.8 1 0 0 1 1 1 0 N-terminal domain of fragilysin Flavi_DEAD PF07652.14 EGD99365.1 - 0.12 12.4 0.2 0.71 9.8 0.2 2.3 1 1 0 1 1 1 0 Flavivirus DEAD domain Cupin_8 PF13621.6 EGD99366.1 - 2.7e-15 56.8 0.0 1.6e-13 51.0 0.0 2.1 1 1 0 1 1 1 1 Cupin-like domain JmjC PF02373.22 EGD99366.1 - 2.7e-09 37.5 0.1 7.2e-08 32.9 0.1 2.7 1 1 0 1 1 1 1 JmjC domain, hydroxylase F-box-like PF12937.7 EGD99366.1 - 1e-06 28.5 0.0 2.1e-06 27.5 0.0 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EGD99366.1 - 0.0005 19.9 0.0 0.0013 18.6 0.0 1.6 1 0 0 1 1 1 1 F-box domain Elongin_A PF06881.11 EGD99366.1 - 0.064 13.8 0.0 0.15 12.6 0.0 1.5 1 0 0 1 1 1 0 RNA polymerase II transcription factor SIII (Elongin) subunit A Ctr PF04145.15 EGD99367.1 - 2.9e-29 102.6 0.2 3.9e-29 102.2 0.2 1.2 1 0 0 1 1 1 1 Ctr copper transporter family NuA4 PF09340.10 EGD99368.1 - 1.9e-27 94.9 0.1 1.9e-27 94.9 0.1 1.6 2 0 0 2 2 2 1 Histone acetyltransferase subunit NuA4 Glyco_hydro_38N PF01074.22 EGD99369.1 - 4.5e-87 292.1 0.8 9.4e-87 291.0 0.8 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 N-terminal domain Glyco_hydro_38C PF07748.13 EGD99369.1 - 1.8e-55 188.4 0.3 1.6e-54 185.3 0.2 2.2 2 0 0 2 2 2 1 Glycosyl hydrolases family 38 C-terminal domain Alpha-mann_mid PF09261.11 EGD99369.1 - 2e-25 88.7 0.0 4.1e-25 87.8 0.0 1.5 1 0 0 1 1 1 1 Alpha mannosidase middle domain Glyco_hydro38C2 PF17677.1 EGD99369.1 - 7e-09 35.7 0.0 1.8e-08 34.4 0.0 1.8 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal beta sandwich domain 7TMR-DISMED2 PF07696.11 EGD99369.1 - 0.081 13.0 0.3 0.89 9.6 0.1 2.5 2 0 0 2 2 2 0 7TMR-DISM extracellular 2 Glyco_hydro_57 PF03065.15 EGD99369.1 - 0.099 11.8 0.0 0.19 10.9 0.0 1.4 1 0 0 1 1 1 0 Glycosyl hydrolase family 57 Fucosidase_C PF16757.5 EGD99369.1 - 0.15 12.7 0.1 3.9 8.1 0.1 2.5 2 0 0 2 2 2 0 Alpha-L-fucosidase C-terminal domain NUDIX PF00293.28 EGD99371.1 - 3.7e-09 36.7 0.1 1.4e-08 34.9 0.0 2.0 2 1 0 2 2 2 1 NUDIX domain PHINT_rpt PF14882.6 EGD99371.1 - 0.066 13.5 0.4 0.19 12.0 0.4 1.7 1 0 0 1 1 1 0 Phage-integrase repeat unit TRM13 PF05206.14 EGD99371.1 - 0.089 12.3 0.0 0.13 11.7 0.0 1.1 1 0 0 1 1 1 0 Methyltransferase TRM13 LETM1 PF07766.13 EGD99372.1 - 3.3e-103 344.7 0.1 5.8e-103 343.9 0.1 1.4 1 0 0 1 1 1 1 LETM1-like protein SAP PF02037.27 EGD99372.1 - 0.0083 15.9 0.0 0.55 10.1 0.0 3.0 3 0 0 3 3 3 1 SAP domain DUF2838 PF10998.8 EGD99373.1 - 2.5e-39 133.9 11.0 2.5e-39 133.9 11.0 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF2838) Exonuc_VII_L PF02601.15 EGD99373.1 - 0.063 12.8 0.3 0.095 12.3 0.3 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Tropomyosin_1 PF12718.7 EGD99373.1 - 0.08 13.1 2.5 0.15 12.2 2.5 1.3 1 0 0 1 1 1 0 Tropomyosin like ApoLp-III PF07464.11 EGD99373.1 - 0.23 11.6 2.8 0.41 10.7 2.8 1.3 1 0 0 1 1 1 0 Apolipophorin-III precursor (apoLp-III) OmpH PF03938.14 EGD99373.1 - 4.8 7.5 8.6 1.8 8.9 5.6 1.7 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) DUF4538 PF15061.6 EGD99375.1 - 0.13 12.1 0.1 0.35 10.6 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4538) Ank_2 PF12796.7 EGD99377.1 - 1.5e-20 73.5 0.7 3.1e-09 37.3 0.0 3.5 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EGD99377.1 - 1.6e-18 66.8 0.2 2.4e-05 24.8 0.0 4.1 3 1 2 5 5 5 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 EGD99377.1 - 9.6e-18 64.0 1.3 3.2e-05 24.1 0.0 3.4 3 0 0 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EGD99377.1 - 9.7e-14 50.1 2.2 9.5e-05 22.5 0.1 5.1 5 0 0 5 5 5 3 Ankyrin repeat Ank PF00023.30 EGD99377.1 - 7.7e-10 38.8 3.2 0.00025 21.3 0.1 5.2 5 0 0 5 5 5 2 Ankyrin repeat SMC_N PF02463.19 EGD99378.1 - 1.5e-59 201.1 0.0 3.3e-37 128.1 0.0 2.4 2 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 EGD99378.1 - 2.4e-30 105.2 1.1 1.3e-29 102.8 0.0 2.9 4 0 0 4 4 4 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 EGD99378.1 - 1.1e-10 41.8 3.8 1.4e-06 28.3 1.3 4.5 3 2 2 5 5 5 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EGD99378.1 - 6.6e-08 32.2 0.0 1.5e-07 31.0 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_15 PF13175.6 EGD99378.1 - 3.4e-05 23.7 11.2 3.4e-05 23.7 11.2 4.8 2 2 2 4 4 2 1 AAA ATPase domain CALCOCO1 PF07888.11 EGD99378.1 - 0.0013 17.7 3.1 0.0013 17.7 3.1 5.2 3 2 2 5 5 3 2 Calcium binding and coiled-coil domain (CALCOCO1) like SbcCD_C PF13558.6 EGD99378.1 - 0.0029 17.8 0.0 0.031 14.5 0.0 2.8 3 0 0 3 3 3 1 Putative exonuclease SbcCD, C subunit DUF4200 PF13863.6 EGD99378.1 - 0.0057 17.0 5.4 0.0057 17.0 5.4 8.9 4 3 7 11 11 7 4 Domain of unknown function (DUF4200) DUF1664 PF07889.12 EGD99378.1 - 0.85 9.7 63.2 1.3 9.1 5.3 9.0 6 4 6 12 12 12 0 Protein of unknown function (DUF1664) Nbl1_Borealin_N PF10444.9 EGD99378.1 - 3.7 7.3 17.7 1.2 8.8 0.3 4.9 4 0 0 4 4 4 0 Nbl1 / Borealin N terminal NPV_P10 PF05531.12 EGD99378.1 - 9.1 6.8 41.7 8.9 6.9 0.2 8.8 7 1 1 8 8 8 0 Nucleopolyhedrovirus P10 protein WH1 PF00568.23 EGD99379.1 - 0.1 12.6 0.1 4.2 7.3 0.0 2.4 2 0 0 2 2 2 0 WH1 domain acVLRF1 PF18859.1 EGD99379.1 - 0.13 12.5 0.0 0.23 11.7 0.0 1.3 1 0 0 1 1 1 0 Actinobacteria/chloroflexi VLRF1 release factor E3_binding PF02817.17 EGD99380.1 - 4e-13 49.5 0.1 3.8e-11 43.1 0.0 2.5 2 0 0 2 2 2 2 e3 binding domain NAD_Gly3P_dh_C PF07479.14 EGD99380.1 - 0.12 12.6 0.0 0.34 11.2 0.0 1.7 2 0 0 2 2 2 0 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus Abhydrolase_2 PF02230.16 EGD99381.1 - 4.2e-20 72.5 0.0 2.1e-15 57.1 0.0 3.2 2 1 0 2 2 2 2 Phospholipase/Carboxylesterase Sulphotransf PF09037.10 EGD99381.1 - 0.0087 15.6 0.0 0.013 15.0 0.0 1.2 1 0 0 1 1 1 1 Stf0 sulphotransferase CM_1 PF07736.11 EGD99381.1 - 0.086 13.2 0.0 0.18 12.2 0.0 1.5 1 0 0 1 1 1 0 Chorismate mutase type I HNH_2 PF13391.6 EGD99382.1 - 1.3e-14 54.1 0.1 2.3e-14 53.3 0.1 1.4 1 0 0 1 1 1 1 HNH endonuclease WD40 PF00400.32 EGD99383.1 - 2e-24 85.4 13.5 0.00012 22.8 0.0 6.6 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EGD99383.1 - 1.8e-14 53.8 6.4 0.00037 20.7 0.3 4.3 3 1 1 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EGD99383.1 - 5.1e-08 33.0 0.1 0.0049 16.8 0.0 3.2 2 1 1 3 3 3 3 Eukaryotic translation initiation factor eIF2A PALB2_WD40 PF16756.5 EGD99383.1 - 0.017 14.1 0.9 3.2 6.6 0.1 2.3 2 0 0 2 2 2 0 Partner and localizer of BRCA2 WD40 domain Ge1_WD40 PF16529.5 EGD99383.1 - 0.019 13.9 0.0 0.056 12.4 0.0 1.8 2 1 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Peptidase_M18 PF02127.15 EGD99384.1 - 3.4e-166 553.3 0.0 3.9e-166 553.2 0.0 1.0 1 0 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) Sugar_tr PF00083.24 EGD99385.1 - 1.7e-39 135.9 10.0 9.4e-33 113.7 6.9 2.2 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 EGD99385.1 - 7.5e-28 97.5 26.5 1e-23 83.9 18.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 EGD99385.1 - 0.00024 19.5 5.2 0.00067 18.1 5.3 1.6 2 0 0 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family MFAP1 PF06991.11 EGD99385.1 - 0.96 9.2 6.5 1.7 8.4 6.5 1.3 1 0 0 1 1 1 0 Microfibril-associated/Pre-mRNA processing Hydrolase_6 PF13344.6 EGD99386.1 - 1e-28 99.4 0.0 1.6e-28 98.7 0.0 1.4 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EGD99386.1 - 9e-17 60.9 0.0 2e-16 59.8 0.0 1.6 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.26 EGD99386.1 - 7e-11 42.8 0.2 1e-08 35.8 0.2 3.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 EGD99386.1 - 1.9e-06 28.1 0.1 0.086 12.9 0.0 2.5 2 1 0 2 2 2 2 Haloacid dehalogenase-like hydrolase UPF0253 PF06786.12 EGD99386.1 - 0.049 13.9 0.0 0.12 12.7 0.0 1.7 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0253) Acid_phosphat_B PF03767.14 EGD99386.1 - 0.053 13.1 0.0 0.078 12.6 0.0 1.2 1 0 0 1 1 1 0 HAD superfamily, subfamily IIIB (Acid phosphatase) Mhr1 PF12829.7 EGD99387.1 - 0.0044 17.1 0.0 0.012 15.7 0.0 1.7 1 0 0 1 1 1 1 Transcriptional regulation of mitochondrial recombination UPF0561 PF10573.9 EGD99387.1 - 0.067 13.3 0.1 5.6 7.1 0.0 2.4 2 0 0 2 2 2 0 Uncharacterised protein family UPF0561 DUF1746 PF08508.10 EGD99388.1 - 2.5e-43 147.1 0.4 3.4e-43 146.6 0.4 1.2 1 0 0 1 1 1 1 Fungal domain of unknown function (DUF1746) CLP_protease PF00574.23 EGD99389.1 - 3e-71 239.1 0.0 3.8e-71 238.7 0.0 1.1 1 0 0 1 1 1 1 Clp protease DHDPS PF00701.22 EGD99389.1 - 0.0064 15.2 0.0 0.011 14.5 0.0 1.3 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family Rep_fac_C PF08542.11 EGD99390.1 - 4.9e-24 84.5 0.1 1.3e-23 83.2 0.1 1.7 1 0 0 1 1 1 1 Replication factor C C-terminal domain AAA PF00004.29 EGD99390.1 - 4.2e-12 46.6 0.0 1.2e-11 45.1 0.0 1.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.6 EGD99390.1 - 2.3e-09 37.2 0.0 3.3e-07 30.2 0.0 2.5 2 0 0 2 2 2 1 DNA polymerase III, delta subunit Rad17 PF03215.15 EGD99390.1 - 6.7e-07 29.4 0.0 2.7e-06 27.4 0.0 2.0 1 1 0 1 1 1 1 Rad17 P-loop domain AAA_assoc_2 PF16193.5 EGD99390.1 - 3.3e-05 24.1 0.3 0.00013 22.2 0.1 2.1 2 0 0 2 2 2 1 AAA C-terminal domain RuvB_N PF05496.12 EGD99390.1 - 0.00023 20.9 0.0 0.00062 19.5 0.0 1.7 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_11 PF13086.6 EGD99390.1 - 0.0015 18.4 0.0 0.0037 17.1 0.0 1.8 1 1 0 1 1 1 1 AAA domain DUF815 PF05673.13 EGD99390.1 - 0.0019 17.4 0.0 0.0041 16.3 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_24 PF13479.6 EGD99390.1 - 0.0037 17.0 0.0 0.017 14.8 0.0 2.1 2 1 0 2 2 2 1 AAA domain AAA_22 PF13401.6 EGD99390.1 - 0.0074 16.6 0.5 0.24 11.7 0.1 2.9 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EGD99390.1 - 0.01 16.2 0.2 0.18 12.2 0.0 2.6 2 1 1 3 3 3 0 AAA ATPase domain Mg_chelatase PF01078.21 EGD99390.1 - 0.016 14.6 0.0 0.7 9.2 0.0 2.3 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_19 PF13245.6 EGD99390.1 - 0.024 15.0 0.1 0.17 12.2 0.1 2.3 1 1 0 1 1 1 0 AAA domain DUF2075 PF09848.9 EGD99390.1 - 0.047 12.9 0.0 0.12 11.6 0.0 1.6 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_7 PF12775.7 EGD99390.1 - 0.13 11.8 0.0 0.23 11.0 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region MFS_1 PF07690.16 EGD99391.1 - 1.1e-42 146.3 50.6 1.1e-42 146.3 50.6 1.7 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EGD99391.1 - 5.1e-11 41.7 16.9 5.1e-11 41.7 16.9 1.4 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 EGD99391.1 - 8.9e-11 41.3 14.2 8.9e-11 41.3 14.2 2.6 2 2 0 2 2 2 2 Sugar (and other) transporter DUF3522 PF12036.8 EGD99391.1 - 0.0018 18.6 2.3 0.0046 17.3 0.3 2.7 1 1 1 2 2 2 1 Protein of unknown function (DUF3522) Sec20 PF03908.13 EGD99392.1 - 5.9e-16 58.2 2.8 1.6e-15 56.8 2.8 1.8 1 0 0 1 1 1 1 Sec20 MRP_L53 PF10780.9 EGD99393.1 - 5.9e-14 52.0 0.1 7.8e-14 51.6 0.1 1.2 1 0 0 1 1 1 1 39S ribosomal protein L53/MRP-L53 RPN5_C PF18098.1 EGD99393.1 - 0.13 12.4 0.0 0.22 11.7 0.0 1.3 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN5 C-terminal domain Pyrophosphatase PF00719.19 EGD99394.1 - 1.2e-57 194.1 0.1 1.6e-57 193.8 0.1 1.1 1 0 0 1 1 1 1 Inorganic pyrophosphatase Dus PF01207.17 EGD99395.1 - 4.4e-42 144.3 0.0 1.1e-41 142.9 0.0 1.6 1 1 0 1 1 1 1 Dihydrouridine synthase (Dus) Peptidase_M28 PF04389.17 EGD99396.1 - 2.5e-43 148.1 0.1 4.3e-43 147.3 0.1 1.4 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.22 EGD99396.1 - 4.1e-13 49.1 0.3 1.1e-12 47.8 0.3 1.8 1 0 0 1 1 1 1 PA domain Peptidase_M20 PF01546.28 EGD99396.1 - 0.0047 16.6 0.0 0.0091 15.7 0.0 1.6 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 Peptidase_M42 PF05343.14 EGD99396.1 - 0.04 12.9 0.0 1 8.3 0.0 2.2 2 0 0 2 2 2 0 M42 glutamyl aminopeptidase SNF2_N PF00176.23 EGD99397.1 - 2e-51 174.8 0.1 3.1e-51 174.1 0.1 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EGD99397.1 - 1.4e-19 70.5 0.4 2.1e-18 66.7 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EGD99397.1 - 2.1e-08 34.4 0.0 5.1e-08 33.1 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 EGD99397.1 - 2.4e-06 27.0 0.1 4.7e-06 26.0 0.1 1.4 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase DEAD PF00270.29 EGD99397.1 - 2.3e-05 24.3 0.0 4.5e-05 23.3 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase TRAM_LAG1_CLN8 PF03798.16 EGD99401.1 - 2.4e-36 125.4 15.8 4.5e-36 124.4 15.8 1.5 1 0 0 1 1 1 1 TLC domain TRAM1 PF08390.11 EGD99401.1 - 2.7e-24 84.6 0.1 7e-24 83.3 0.1 1.8 1 0 0 1 1 1 1 TRAM1-like protein MIP PF00230.20 EGD99401.1 - 0.081 12.6 0.6 0.12 12.1 0.6 1.3 1 0 0 1 1 1 0 Major intrinsic protein Hira PF07569.11 EGD99402.1 - 5.1e-79 265.1 0.0 1e-78 264.1 0.0 1.6 1 0 0 1 1 1 1 TUP1-like enhancer of split WD40 PF00400.32 EGD99402.1 - 4e-28 97.1 27.3 6.9e-05 23.5 0.0 9.7 8 1 1 9 9 9 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EGD99402.1 - 1.4e-14 54.2 0.1 0.1 12.9 0.0 6.5 4 1 3 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain HIRA_B PF09453.10 EGD99402.1 - 1.5e-10 40.7 0.1 4.2e-10 39.2 0.1 1.8 1 0 0 1 1 1 1 HIRA B motif PD40 PF07676.12 EGD99402.1 - 1.7e-06 27.8 6.0 0.43 10.6 0.0 6.3 7 0 0 7 7 7 2 WD40-like Beta Propeller Repeat Ge1_WD40 PF16529.5 EGD99402.1 - 0.00051 19.1 1.0 2.2 7.2 0.0 4.9 3 1 2 5 5 5 1 WD40 region of Ge1, enhancer of mRNA-decapping protein IKI3 PF04762.12 EGD99402.1 - 0.0014 16.7 0.0 0.0039 15.3 0.0 1.6 1 1 1 2 2 2 1 IKI3 family YchF-GTPase_C PF06071.13 EGD99403.1 - 1.7e-33 114.6 0.1 3.9e-33 113.5 0.1 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF933) MMR_HSR1 PF01926.23 EGD99403.1 - 2e-17 63.3 0.0 8.4e-17 61.3 0.0 1.9 1 1 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EGD99403.1 - 0.00055 19.5 0.0 0.0013 18.3 0.0 1.6 1 0 0 1 1 1 1 Ferrous iron transport protein B TGS PF02824.21 EGD99403.1 - 0.011 15.8 0.1 0.041 13.9 0.1 2.0 2 1 0 2 2 2 0 TGS domain Glyco_hydro_79n PF03662.14 EGD99403.1 - 0.081 11.8 0.0 0.12 11.3 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 79, N-terminal domain AAA_14 PF13173.6 EGD99403.1 - 0.13 12.4 0.0 0.32 11.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain Pre-PUA PF17832.1 EGD99404.1 - 1.6e-22 80.0 0.1 2.2e-22 79.6 0.1 1.2 1 0 0 1 1 1 1 Pre-PUA-like domain PUA PF01472.20 EGD99404.1 - 9.2e-14 51.2 0.3 1.4e-13 50.6 0.3 1.3 1 0 0 1 1 1 1 PUA domain DUF1947 PF09183.10 EGD99404.1 - 0.16 12.3 0.0 0.3 11.4 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1947) RIC1 PF07064.13 EGD99405.1 - 9.9e-79 264.3 0.0 1.6e-78 263.6 0.0 1.3 1 0 0 1 1 1 1 RIC1 SGTA_dimer PF16546.5 EGD99406.1 - 1.1e-23 82.7 0.1 1.9e-23 82.0 0.1 1.4 1 0 0 1 1 1 1 Homodimerisation domain of SGTA TPR_2 PF07719.17 EGD99406.1 - 4.1e-13 48.3 6.5 0.001 19.0 0.1 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 EGD99406.1 - 5.8e-13 48.1 4.2 0.00012 21.7 0.1 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 EGD99406.1 - 6.2e-10 38.6 6.3 4.6e-07 29.4 0.8 3.0 1 1 2 3 3 3 2 TPR repeat TPR_16 PF13432.6 EGD99406.1 - 6.3e-09 36.3 19.9 4e-06 27.4 5.4 2.6 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 EGD99406.1 - 3.4e-06 26.9 4.3 0.3 11.4 0.1 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 EGD99406.1 - 3.2e-05 24.0 0.7 0.091 13.2 0.3 3.0 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 EGD99406.1 - 4.1e-05 23.8 3.2 0.00077 19.7 0.6 2.8 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 EGD99406.1 - 4.2e-05 24.0 7.1 0.089 13.7 0.7 3.6 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_19 PF14559.6 EGD99406.1 - 0.00017 22.0 2.1 0.0012 19.4 0.6 2.4 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.6 EGD99406.1 - 0.00019 21.2 0.2 13 6.1 0.0 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat STI1 PF17830.1 EGD99406.1 - 0.00019 21.3 11.4 0.0022 17.9 6.2 2.9 3 0 0 3 3 3 1 STI1 domain XPC-binding PF09280.11 EGD99406.1 - 0.00043 20.0 3.4 0.0014 18.3 3.3 1.8 2 0 0 2 2 2 1 XPC-binding domain TPR_9 PF13371.6 EGD99406.1 - 0.00054 20.0 1.7 0.0073 16.4 0.3 2.3 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_10 PF13374.6 EGD99406.1 - 0.035 14.0 4.5 0.1 12.5 0.6 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat GerD PF17898.1 EGD99406.1 - 0.15 12.0 1.3 0.76 9.7 0.4 2.4 2 0 0 2 2 2 0 Spore germination GerD central core domain DUF4264 PF14084.6 EGD99406.1 - 0.21 11.2 0.0 0.48 10.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4264) TPR_6 PF13174.6 EGD99406.1 - 0.6 10.9 5.2 9.5 7.1 0.2 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat Tim44 PF04280.15 EGD99407.1 - 3.3e-37 127.8 0.1 8e-37 126.6 0.0 1.7 2 0 0 2 2 2 1 Tim44-like domain Spt20 PF12090.8 EGD99407.1 - 0.38 10.3 6.4 0.6 9.7 6.4 1.4 1 0 0 1 1 1 0 Spt20 family TRAP_alpha PF03896.16 EGD99407.1 - 5 6.3 6.6 1.5 7.9 2.3 2.0 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit TraV PF09676.10 EGD99408.1 - 0.49 11.4 2.6 0.71 10.9 2.6 1.3 1 0 0 1 1 1 0 Type IV conjugative transfer system lipoprotein (TraV) VPS9 PF02204.18 EGD99409.1 - 1.9e-18 66.6 0.1 5.1e-18 65.2 0.1 1.8 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain Ank_5 PF13857.6 EGD99409.1 - 5.6e-16 58.4 0.6 2.3e-13 50.0 0.0 3.7 4 0 0 4 4 4 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 EGD99409.1 - 2.7e-11 43.9 0.0 0.0031 18.1 0.0 3.8 1 1 3 4 4 4 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EGD99409.1 - 5.4e-05 23.6 0.3 0.39 11.3 0.0 5.1 4 1 1 5 5 5 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EGD99409.1 - 6.9e-05 22.9 0.1 0.69 10.7 0.0 5.4 5 0 0 5 5 5 1 Ankyrin repeat PX PF00787.24 EGD99409.1 - 8e-05 22.6 0.6 0.00024 21.0 0.6 1.8 1 0 0 1 1 1 1 PX domain Ank PF00023.30 EGD99409.1 - 0.0077 16.6 0.4 12 6.5 0.0 4.3 4 0 0 4 4 4 1 Ankyrin repeat Inhibitor_I78 PF11720.8 EGD99411.1 - 6.5e-13 48.5 0.0 7.8e-13 48.3 0.0 1.1 1 0 0 1 1 1 1 Peptidase inhibitor I78 family potato_inhibit PF00280.18 EGD99411.1 - 0.00016 22.2 0.1 0.00021 21.9 0.1 1.4 1 1 0 1 1 1 1 Potato inhibitor I family Nefa_Nip30_N PF10187.9 EGD99412.1 - 7.3e-32 109.8 11.4 7.3e-32 109.8 11.4 2.0 2 0 0 2 2 2 1 N-terminal domain of NEFA-interacting nuclear protein NIP30 DUF572 PF04502.13 EGD99412.1 - 0.00084 19.1 13.1 0.0011 18.7 13.1 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF572) Golgin_A5 PF09787.9 EGD99412.1 - 1.1 8.7 12.4 1.7 8.0 12.4 1.3 1 0 0 1 1 1 0 Golgin subfamily A member 5 CK_II_beta PF01214.18 EGD99414.1 - 4.6e-78 261.2 0.1 6.4e-78 260.7 0.1 1.2 1 0 0 1 1 1 1 Casein kinase II regulatory subunit RNA_pol_3_Rpc31 PF11705.8 EGD99414.1 - 0.0066 16.7 3.7 0.0098 16.2 3.7 1.3 1 0 0 1 1 1 1 DNA-directed RNA polymerase III subunit Rpc31 zf-B_box PF00643.24 EGD99414.1 - 0.47 10.7 1.9 0.68 10.1 0.4 1.9 2 0 0 2 2 2 0 B-box zinc finger E1-E2_ATPase PF00122.20 EGD99415.1 - 7.9e-46 155.9 2.0 7.9e-46 155.9 2.0 2.9 4 0 0 4 4 4 1 E1-E2 ATPase Hydrolase PF00702.26 EGD99415.1 - 8.4e-24 85.0 0.1 2e-23 83.8 0.1 1.7 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HMA PF00403.26 EGD99415.1 - 6.6e-10 39.3 0.0 1.8e-09 37.9 0.0 1.8 1 0 0 1 1 1 1 Heavy-metal-associated domain Hydrolase_3 PF08282.12 EGD99415.1 - 0.00021 21.1 0.1 0.63 9.7 0.0 2.3 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase CoA_binding_2 PF13380.6 EGD99415.1 - 0.00057 20.4 0.1 0.0019 18.7 0.1 2.0 1 0 0 1 1 1 1 CoA binding domain HAD PF12710.7 EGD99415.1 - 0.025 15.0 0.1 0.094 13.1 0.0 2.0 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase Fungal_trans_2 PF11951.8 EGD99416.1 - 2.9e-38 131.7 1.2 7.2e-19 67.8 0.0 2.0 2 0 0 2 2 2 2 Fungal specific transcription factor domain Zn_clus PF00172.18 EGD99416.1 - 4.5e-07 29.9 10.7 9.9e-07 28.8 10.7 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Arr-ms PF12120.8 EGD99416.1 - 0.047 13.9 0.0 4.6 7.5 0.0 2.3 2 0 0 2 2 2 0 Rifampin ADP-ribosyl transferase Abhydrolase_3 PF07859.13 EGD99417.1 - 6.2e-07 29.5 0.4 1.7e-06 28.1 0.4 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold Thioesterase PF00975.20 EGD99417.1 - 0.04 14.0 0.4 0.062 13.4 0.4 1.4 1 1 0 1 1 1 0 Thioesterase domain Abhydrolase_6 PF12697.7 EGD99417.1 - 0.042 14.5 2.6 0.055 14.1 2.6 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EGD99417.1 - 0.063 12.9 0.1 0.084 12.5 0.1 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold DUF3089 PF11288.8 EGD99417.1 - 0.098 12.2 0.0 0.15 11.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3089) NmrA PF05368.13 EGD99418.1 - 9.1e-11 41.7 0.0 1e-10 41.6 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EGD99418.1 - 2.1e-08 34.3 0.0 3e-08 33.8 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding Sacchrp_dh_NADP PF03435.18 EGD99418.1 - 0.00012 22.3 0.0 0.00021 21.6 0.0 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Peptidase_S10 PF00450.22 EGD99419.1 - 7.7e-101 338.5 0.3 5e-100 335.9 0.3 1.9 1 1 0 1 1 1 1 Serine carboxypeptidase Abhydrolase_1 PF00561.20 EGD99420.1 - 1.4e-32 113.3 0.0 1.8e-32 113.0 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EGD99420.1 - 2.6e-16 59.7 0.0 4.7e-16 58.8 0.0 1.3 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EGD99420.1 - 2.3e-09 38.2 0.1 3.3e-09 37.7 0.1 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_4 PF08386.10 EGD99420.1 - 0.00015 21.9 0.0 0.00026 21.1 0.0 1.4 1 0 0 1 1 1 1 TAP-like protein FSH1 PF03959.13 EGD99420.1 - 0.014 15.1 0.0 0.33 10.6 0.0 2.1 2 0 0 2 2 2 0 Serine hydrolase (FSH1) Esterase PF00756.20 EGD99420.1 - 0.045 13.4 0.1 0.15 11.6 0.1 2.0 1 1 0 1 1 1 0 Putative esterase Ndr PF03096.14 EGD99420.1 - 0.14 10.8 0.0 0.2 10.3 0.0 1.2 1 0 0 1 1 1 0 Ndr family SUIM_assoc PF16619.5 EGD99421.1 - 0.089 12.9 0.3 0.089 12.9 0.3 2.6 2 1 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 SPX PF03105.19 EGD99421.1 - 0.85 9.5 15.1 1.3 8.9 15.1 1.3 1 0 0 1 1 1 0 SPX domain RSN1_7TM PF02714.15 EGD99422.1 - 1.3e-85 287.0 28.0 1.1e-84 284.0 24.4 2.4 2 0 0 2 2 2 2 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 EGD99422.1 - 1.8e-45 154.5 2.3 1.8e-45 154.5 2.3 2.4 2 0 0 2 2 2 1 Late exocytosis, associated with Golgi transport PHM7_ext PF12621.8 EGD99422.1 - 1e-27 96.2 0.4 1.1e-26 92.8 0.2 2.4 3 0 0 3 3 3 1 Extracellular tail, of 10TM putative phosphate transporter PHM7_cyt PF14703.6 EGD99422.1 - 7.9e-18 65.3 0.2 1.4e-17 64.5 0.2 1.4 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter Rubella_E2 PF05749.11 EGD99422.1 - 0.051 13.0 0.0 0.14 11.6 0.0 1.7 1 0 0 1 1 1 0 Rubella membrane glycoprotein E2 zf-C3HC4_3 PF13920.6 EGD99423.1 - 5e-07 29.5 9.5 5e-07 29.5 9.5 3.6 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EGD99423.1 - 3.7 7.5 20.1 0.064 13.1 11.0 2.5 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) MutS_V PF00488.21 EGD99424.1 - 1.8e-61 207.5 0.4 3.2e-61 206.6 0.4 1.4 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 EGD99424.1 - 1.6e-32 113.3 1.3 3.7e-32 112.1 1.3 1.7 1 0 0 1 1 1 1 MutS domain III MutS_IV PF05190.18 EGD99424.1 - 4.4e-12 46.2 0.5 1.2e-10 41.6 0.1 2.7 2 0 0 2 2 2 1 MutS family domain IV MutS_II PF05188.17 EGD99424.1 - 1.7e-11 44.5 0.2 6.4e-11 42.7 0.2 2.0 1 0 0 1 1 1 1 MutS domain II RasGEF_N_2 PF14663.6 EGD99424.1 - 0.0086 16.5 1.8 6.6 7.2 0.1 3.5 3 1 1 4 4 4 2 Rapamycin-insensitive companion of mTOR RasGEF_N domain AAA_30 PF13604.6 EGD99424.1 - 0.014 15.1 0.0 0.032 13.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain DUF3213 PF11491.8 EGD99424.1 - 0.09 13.0 0.0 0.24 11.6 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3213) HMGL-like PF00682.19 EGD99424.1 - 0.096 12.2 0.3 0.21 11.1 0.0 1.7 2 0 0 2 2 2 0 HMGL-like AAA_14 PF13173.6 EGD99424.1 - 0.11 12.5 0.0 0.46 10.5 0.0 2.1 1 0 0 1 1 1 0 AAA domain WD40 PF00400.32 EGD99425.1 - 1.2e-60 200.0 30.0 1.6e-11 44.5 0.4 9.4 9 1 0 9 9 9 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EGD99425.1 - 3.9e-22 78.3 4.9 0.00035 20.8 0.1 6.0 2 2 5 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EGD99425.1 - 2.6e-07 29.7 5.5 0.52 8.9 0.0 5.7 5 1 1 6 6 6 2 Nucleoporin Nup120/160 eIF2A PF08662.11 EGD99425.1 - 1.5e-06 28.2 0.1 0.058 13.3 0.0 3.6 2 1 2 4 4 4 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 EGD99425.1 - 4e-06 26.0 0.0 0.069 12.1 0.0 4.8 4 1 1 5 5 5 1 WD40 region of Ge1, enhancer of mRNA-decapping protein NLE PF08154.12 EGD99425.1 - 3.1e-05 24.4 0.0 6.6e-05 23.4 0.0 1.6 1 0 0 1 1 1 1 NLE (NUC135) domain WD40_like PF17005.5 EGD99425.1 - 0.015 14.7 0.0 18 4.5 0.0 4.0 3 2 1 5 5 5 0 WD40-like domain DUF4550 PF15084.6 EGD99425.1 - 0.02 15.3 0.1 0.19 12.2 0.0 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4550) FAD_binding_9 PF08021.11 EGD99425.1 - 0.031 14.5 0.0 0.74 10.0 0.0 2.9 3 0 0 3 3 3 0 Siderophore-interacting FAD-binding domain PD40 PF07676.12 EGD99425.1 - 0.12 12.4 0.5 35 4.5 0.0 3.8 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat Sec10 PF07393.11 EGD99426.1 - 2.6e-152 508.8 0.1 3.3e-152 508.5 0.1 1.0 1 0 0 1 1 1 1 Exocyst complex component Sec10 F-box-like PF12937.7 EGD99426.1 - 1.8e-05 24.6 0.0 3.8e-05 23.5 0.0 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EGD99426.1 - 8.4e-05 22.3 0.3 0.00022 21.0 0.0 1.8 2 0 0 2 2 2 1 F-box domain RINT1_TIP1 PF04437.13 EGD99426.1 - 0.014 14.3 0.1 0.048 12.6 0.0 1.8 2 0 0 2 2 2 0 RINT-1 / TIP-1 family AAA PF00004.29 EGD99427.1 - 1.8e-30 106.1 0.0 3.5e-30 105.1 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EGD99427.1 - 4.5e-06 27.0 0.1 2.2e-05 24.8 0.1 2.0 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EGD99427.1 - 1.1e-05 25.9 0.0 2.3e-05 24.8 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_18 PF13238.6 EGD99427.1 - 3.5e-05 24.4 0.0 8.2e-05 23.2 0.0 1.7 2 0 0 2 2 1 1 AAA domain AAA_25 PF13481.6 EGD99427.1 - 0.00016 21.3 0.0 0.00038 20.1 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.14 EGD99427.1 - 0.00047 20.2 0.1 0.0012 18.9 0.1 1.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_14 PF13173.6 EGD99427.1 - 0.00048 20.2 0.0 0.00084 19.4 0.0 1.3 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.12 EGD99427.1 - 0.0005 19.9 0.1 0.016 15.0 0.0 2.2 1 1 1 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain RNA_helicase PF00910.22 EGD99427.1 - 0.00061 20.2 0.1 0.0019 18.6 0.0 1.9 2 0 0 2 2 1 1 RNA helicase AAA_24 PF13479.6 EGD99427.1 - 0.001 18.8 0.0 0.002 17.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain NACHT PF05729.12 EGD99427.1 - 0.0012 18.7 0.0 0.0022 18.0 0.0 1.4 1 1 0 1 1 1 1 NACHT domain AAA_33 PF13671.6 EGD99427.1 - 0.0052 16.9 0.0 0.013 15.6 0.0 1.5 1 1 0 1 1 1 1 AAA domain TsaE PF02367.17 EGD99427.1 - 0.0053 16.7 0.0 0.0096 15.9 0.0 1.3 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE ATPase_2 PF01637.18 EGD99427.1 - 0.011 15.7 0.1 0.44 10.4 0.0 2.2 1 1 1 2 2 2 0 ATPase domain predominantly from Archaea AAA_28 PF13521.6 EGD99427.1 - 0.011 16.0 0.0 0.022 15.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_2 PF07724.14 EGD99427.1 - 0.013 15.7 0.0 0.026 14.6 0.0 1.5 1 1 0 1 1 1 0 AAA domain (Cdc48 subfamily) Mg_chelatase PF01078.21 EGD99427.1 - 0.014 14.8 0.0 0.18 11.2 0.0 2.2 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI Cytidylate_kin PF02224.18 EGD99427.1 - 0.017 14.8 0.2 0.04 13.6 0.0 1.6 2 0 0 2 2 2 0 Cytidylate kinase IstB_IS21 PF01695.17 EGD99427.1 - 0.021 14.6 0.0 0.039 13.7 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_17 PF13207.6 EGD99427.1 - 0.021 15.3 0.3 0.18 12.3 0.1 2.2 1 1 0 2 2 2 0 AAA domain AAA_11 PF13086.6 EGD99427.1 - 0.028 14.2 0.0 0.045 13.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain DUF815 PF05673.13 EGD99427.1 - 0.033 13.4 0.0 0.065 12.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_13 PF13166.6 EGD99427.1 - 0.044 12.4 0.0 0.058 12.0 0.0 1.1 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 EGD99427.1 - 0.046 13.4 0.0 0.075 12.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 EGD99427.1 - 0.049 13.1 0.0 0.1 12.1 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region Rad17 PF03215.15 EGD99427.1 - 0.065 13.2 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_19 PF13245.6 EGD99427.1 - 0.071 13.4 0.2 0.36 11.1 0.0 2.0 1 1 0 2 2 2 0 AAA domain AAA_3 PF07726.11 EGD99427.1 - 0.073 12.9 0.0 0.17 11.8 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) DnaB_C PF03796.15 EGD99427.1 - 0.087 12.1 0.0 0.26 10.6 0.0 1.7 1 1 1 2 2 2 0 DnaB-like helicase C terminal domain TIP49 PF06068.13 EGD99427.1 - 0.11 11.7 0.0 0.18 11.0 0.0 1.2 1 0 0 1 1 1 0 TIP49 P-loop domain Cytochrom_C1 PF02167.15 EGD99428.1 - 9.9e-93 309.9 0.0 1.2e-92 309.6 0.0 1.1 1 0 0 1 1 1 1 Cytochrome C1 family SbcCD_C PF13558.6 EGD99428.1 - 0.003 17.8 0.2 0.0061 16.8 0.2 1.5 1 0 0 1 1 1 1 Putative exonuclease SbcCD, C subunit Cytochrome_CBB3 PF13442.6 EGD99428.1 - 0.051 13.9 0.0 0.11 12.8 0.0 1.7 1 0 0 1 1 1 0 Cytochrome C oxidase, cbb3-type, subunit III AIG2_2 PF13772.6 EGD99429.1 - 1.2e-05 25.7 0.0 0.00014 22.2 0.0 2.3 2 0 0 2 2 2 1 AIG2-like family DAHP_synth_1 PF00793.20 EGD99432.1 - 3.9e-103 344.1 0.1 5e-103 343.8 0.1 1.0 1 0 0 1 1 1 1 DAHP synthetase I family MFS_1 PF07690.16 EGD99433.1 - 6.6e-20 71.3 27.0 6.6e-20 71.3 27.0 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily RSN1_7TM PF02714.15 EGD99434.1 - 2.5e-81 273.0 21.0 2.5e-81 273.0 21.0 1.7 2 0 0 2 2 2 1 Calcium-dependent channel, 7TM region, putative phosphate PHM7_cyt PF14703.6 EGD99434.1 - 1.8e-41 142.3 0.0 2.8e-41 141.7 0.0 1.3 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter RSN1_TM PF13967.6 EGD99434.1 - 3.5e-35 121.1 0.8 3.5e-35 121.1 0.8 2.4 3 0 0 3 3 3 1 Late exocytosis, associated with Golgi transport Anoctamin PF04547.12 EGD99434.1 - 0.0015 17.4 2.2 0.0015 17.4 2.2 2.3 3 0 0 3 3 3 1 Calcium-activated chloride channel hDGE_amylase PF14701.6 EGD99435.1 - 1.4e-129 433.0 0.5 1.6e-124 416.4 0.2 3.1 1 1 1 2 2 2 2 Glycogen debranching enzyme, glucanotransferase domain GDE_C PF06202.14 EGD99435.1 - 7.8e-122 406.9 0.1 1.4e-121 406.1 0.0 1.4 2 0 0 2 2 2 1 Amylo-alpha-1,6-glucosidase hGDE_central PF14702.6 EGD99435.1 - 1.8e-84 283.4 0.0 6e-84 281.7 0.0 1.9 2 0 0 2 2 2 1 Central domain of human glycogen debranching enzyme hGDE_N PF14699.6 EGD99435.1 - 1.8e-27 95.3 0.0 3.8e-27 94.2 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain from the human glycogen debranching enzyme NAD_Gly3P_dh_N PF01210.23 EGD99436.1 - 4.6e-45 153.4 0.0 7.6e-45 152.7 0.0 1.3 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_Gly3P_dh_C PF07479.14 EGD99436.1 - 3.3e-43 147.4 0.1 5.7e-43 146.6 0.1 1.3 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus SLX9 PF15341.6 EGD99437.1 - 1.3e-38 132.3 3.7 1.7e-38 132.0 3.7 1.1 1 0 0 1 1 1 1 Ribosome biogenesis protein SLX9 Pilin_GH PF16734.5 EGD99437.1 - 0.012 15.9 0.0 0.021 15.1 0.0 1.4 1 0 0 1 1 1 0 Type IV pilin-like G and H, putative ThiF PF00899.21 EGD99438.1 - 5.5e-50 170.0 0.0 2e-49 168.2 0.0 1.7 1 1 0 1 1 1 1 ThiF family Rhodanese PF00581.20 EGD99438.1 - 4.6e-09 36.8 0.0 1.2e-08 35.4 0.0 1.7 1 0 0 1 1 1 1 Rhodanese-like domain ApbA PF02558.16 EGD99438.1 - 0.014 15.1 0.0 0.022 14.4 0.0 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA NAD_binding_7 PF13241.6 EGD99438.1 - 0.021 15.3 0.0 0.042 14.3 0.0 1.4 1 0 0 1 1 1 0 Putative NAD(P)-binding Spc24 PF08286.11 EGD99438.1 - 0.022 15.0 0.5 0.044 14.0 0.5 1.4 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 DAO PF01266.24 EGD99438.1 - 0.052 13.1 0.0 0.11 12.1 0.0 1.5 2 0 0 2 2 2 0 FAD dependent oxidoreductase FlxA PF14282.6 EGD99438.1 - 0.064 13.2 4.1 0.11 12.5 4.1 1.4 1 0 0 1 1 1 0 FlxA-like protein FAD_binding_3 PF01494.19 EGD99438.1 - 0.066 12.5 0.7 0.1 11.8 0.7 1.3 1 0 0 1 1 1 0 FAD binding domain YlqD PF11068.8 EGD99438.1 - 0.11 12.9 2.7 0.19 12.1 2.7 1.3 1 0 0 1 1 1 0 YlqD protein PRKG1_interact PF15898.5 EGD99438.1 - 0.11 13.4 2.3 0.22 12.5 2.3 1.5 1 0 0 1 1 1 0 cGMP-dependent protein kinase interacting domain Shikimate_DH PF01488.20 EGD99438.1 - 0.16 12.0 0.1 0.49 10.4 0.0 1.7 1 1 1 2 2 2 0 Shikimate / quinate 5-dehydrogenase ABC_tran_CTD PF16326.5 EGD99438.1 - 0.21 11.9 4.6 0.36 11.1 4.6 1.4 1 0 0 1 1 1 0 ABC transporter C-terminal domain Golgin_A5 PF09787.9 EGD99438.1 - 0.24 10.8 2.3 0.39 10.1 2.3 1.3 1 0 0 1 1 1 0 Golgin subfamily A member 5 DivIC PF04977.15 EGD99438.1 - 0.45 10.3 3.7 0.81 9.5 3.7 1.4 1 0 0 1 1 1 0 Septum formation initiator HR1 PF02185.16 EGD99438.1 - 2.8 8.1 7.5 3.1 8.0 6.0 1.8 2 0 0 2 2 2 0 Hr1 repeat DPBB_1 PF03330.18 EGD99439.1 - 4.8e-09 36.4 0.1 2.2e-08 34.2 0.0 2.0 2 0 0 2 2 2 1 Lytic transglycolase Barwin PF00967.17 EGD99439.1 - 0.066 13.1 0.1 0.09 12.6 0.1 1.2 1 0 0 1 1 1 0 Barwin family MARVEL PF01284.23 EGD99439.1 - 0.1 12.7 0.0 0.13 12.3 0.0 1.2 1 0 0 1 1 1 0 Membrane-associating domain Bac_export_3 PF01313.19 EGD99439.1 - 0.27 11.2 2.9 0.41 10.6 2.9 1.2 1 0 0 1 1 1 0 Bacterial export proteins, family 3 PMP1_2 PF08114.11 EGD99440.1 - 0.00051 19.7 0.9 0.00051 19.7 0.9 1.7 2 0 0 2 2 2 1 ATPase proteolipid family MFS_1 PF07690.16 EGD99440.1 - 0.0049 15.8 0.1 0.0051 15.8 0.1 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily 5TM-5TMR_LYT PF07694.12 EGD99440.1 - 0.0064 16.0 0.5 0.14 11.7 0.2 2.0 2 0 0 2 2 2 1 5TMR of 5TMR-LYT DUF4381 PF14316.6 EGD99440.1 - 0.0068 16.7 0.1 0.014 15.6 0.1 1.5 2 0 0 2 2 2 1 Domain of unknown function (DUF4381) DPM2 PF07297.12 EGD99440.1 - 0.031 14.6 0.1 0.049 13.9 0.1 1.3 1 0 0 1 1 1 0 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) Saf_2TM PF18303.1 EGD99440.1 - 0.05 13.2 0.4 0.063 12.9 0.4 1.1 1 0 0 1 1 1 0 SAVED-fused 2TM effector domain Phage_holin_3_5 PF16085.5 EGD99440.1 - 0.11 12.6 0.8 0.39 10.9 0.2 1.8 1 1 1 2 2 2 0 Bacteriophage holin Hol, superfamily III Sec61_beta PF03911.16 EGD99440.1 - 0.3 11.2 2.5 0.61 10.2 2.5 1.6 1 0 0 1 1 1 0 Sec61beta family NAD_binding_11 PF14833.6 EGD99442.1 - 5.5e-42 142.8 0.6 6.7e-27 94.2 0.0 2.2 2 0 0 2 2 2 2 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase NAD_binding_2 PF03446.15 EGD99442.1 - 2.7e-36 125.1 0.1 5.3e-36 124.2 0.1 1.5 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase 3HCDH_N PF02737.18 EGD99442.1 - 0.0005 20.0 0.1 0.00095 19.1 0.1 1.5 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain F420_oxidored PF03807.17 EGD99442.1 - 0.0057 17.2 0.1 0.024 15.2 0.1 2.3 1 1 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent ApbA PF02558.16 EGD99442.1 - 0.015 14.9 0.1 0.04 13.6 0.1 1.7 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA 2-Hacid_dh_C PF02826.19 EGD99442.1 - 0.14 11.5 0.0 0.24 10.7 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain F_bP_aldolase PF01116.20 EGD99443.1 - 2e-83 280.1 0.0 2.3e-83 279.9 0.0 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-II OrfB_IS605 PF01385.19 EGD99443.1 - 0.16 12.2 0.1 0.64 10.3 0.0 1.9 2 0 0 2 2 2 0 Probable transposase Fer2_3 PF13085.6 EGD99444.1 - 1.2e-32 112.1 0.1 2e-32 111.4 0.1 1.3 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Fer4_17 PF13534.6 EGD99444.1 - 9.9e-09 35.6 5.7 9.9e-09 35.6 5.7 2.2 2 1 1 3 3 3 1 4Fe-4S dicluster domain Fer4_8 PF13183.6 EGD99444.1 - 1.7e-07 31.5 6.3 1.7e-07 31.5 6.3 2.4 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_10 PF13237.6 EGD99444.1 - 8.4e-07 29.0 2.5 8.4e-07 29.0 2.5 2.1 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_7 PF12838.7 EGD99444.1 - 0.0021 18.6 4.3 0.0021 18.6 4.3 2.5 2 2 0 2 2 2 1 4Fe-4S dicluster domain Fer2 PF00111.27 EGD99444.1 - 0.0049 16.8 0.4 0.0049 16.8 0.4 2.3 3 0 0 3 3 3 1 2Fe-2S iron-sulfur cluster binding domain SF3a60_bindingd PF12108.8 EGD99444.1 - 0.17 11.8 0.2 0.26 11.2 0.2 1.3 1 0 0 1 1 1 0 Splicing factor SF3a60 binding domain RTA1 PF04479.13 EGD99445.1 - 1.5e-71 240.3 4.8 1.9e-71 240.0 4.8 1.1 1 0 0 1 1 1 1 RTA1 like protein CBP_BcsF PF11120.8 EGD99445.1 - 0.0068 16.5 0.1 0.02 15.0 0.1 1.7 1 0 0 1 1 1 1 Cellulose biosynthesis protein BcsF DUF3493 PF11998.8 EGD99445.1 - 0.058 13.6 0.7 0.23 11.6 0.1 2.3 1 1 2 3 3 3 0 Low psii accumulation1 / Rep27 Abhydrolase_9_N PF15420.6 EGD99445.1 - 0.12 12.4 1.4 0.28 11.2 1.2 1.7 1 1 1 2 2 2 0 Alpha/beta-hydrolase family N-terminus DUF4013 PF13197.6 EGD99445.1 - 1.8 8.4 14.6 0.16 11.8 2.8 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF4013) Velvet PF11754.8 EGD99447.1 - 4.6e-89 298.7 0.3 4.6e-89 298.7 0.3 2.1 2 0 0 2 2 2 1 Velvet factor Git3 PF11710.8 EGD99448.1 - 9.9e-28 97.3 7.6 2e-27 96.3 7.6 1.5 1 1 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 GPR_Gpa2_C PF11970.8 EGD99448.1 - 3.9e-10 39.6 0.0 3.9e-10 39.6 0.0 2.7 3 1 2 5 5 5 1 G protein-coupled glucose receptor regulating Gpa2 C-term Dicty_CAR PF05462.11 EGD99448.1 - 0.0051 16.0 7.5 0.0083 15.3 7.5 1.4 1 1 0 1 1 1 1 Slime mold cyclic AMP receptor SCIMP PF15050.6 EGD99448.1 - 0.24 11.8 0.3 55 4.2 0.0 3.3 3 0 0 3 3 3 0 SCIMP protein Syndecan PF01034.20 EGD99448.1 - 0.43 10.5 2.3 0.77 9.7 0.1 2.4 2 0 0 2 2 2 0 Syndecan domain UPF0370 PF13980.6 EGD99450.1 - 0.023 14.7 3.0 0.19 11.8 1.0 2.5 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0370) DnaJ_CXXCXGXG PF00684.19 EGD99451.1 - 0.0054 17.1 3.4 6.5 7.2 0.1 3.1 3 0 0 3 3 3 2 DnaJ central domain HhH-GPD PF00730.25 EGD99452.1 - 4e-08 33.7 0.0 4.4e-08 33.5 0.0 1.2 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein DUF4332 PF14229.6 EGD99452.1 - 0.086 13.1 0.0 0.13 12.5 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4332) Fasciclin PF02469.22 EGD99453.1 - 4.2e-33 114.3 0.0 4.1e-18 65.8 0.0 2.1 2 0 0 2 2 2 2 Fasciclin domain G_glu_transpept PF01019.21 EGD99454.1 - 1.5e-165 551.9 0.0 1.7e-165 551.7 0.0 1.0 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase AAA PF00004.29 EGD99456.1 - 2.1e-45 154.4 0.1 8e-45 152.5 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 EGD99456.1 - 2.1e-09 37.2 0.0 1.3e-08 34.7 0.0 2.2 2 0 0 2 2 2 1 Proteasomal ATPase OB C-terminal domain AAA_5 PF07728.14 EGD99456.1 - 7.2e-09 35.8 0.1 2.2e-08 34.2 0.1 1.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 EGD99456.1 - 4.9e-08 33.3 0.0 9.8e-08 32.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 EGD99456.1 - 1.4e-07 32.1 0.2 3.7e-05 24.2 0.0 2.8 2 1 0 3 3 3 1 AAA ATPase domain DUF815 PF05673.13 EGD99456.1 - 3.2e-06 26.5 0.0 5.5e-06 25.7 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_22 PF13401.6 EGD99456.1 - 3.9e-05 23.9 1.2 0.0087 16.3 0.1 2.6 1 1 1 2 2 2 1 AAA domain RuvB_N PF05496.12 EGD99456.1 - 0.00013 21.7 0.1 0.00068 19.4 0.0 2.2 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_28 PF13521.6 EGD99456.1 - 0.00019 21.7 0.0 0.0015 18.8 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_lid_3 PF17862.1 EGD99456.1 - 0.00038 20.2 0.0 0.00085 19.1 0.0 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_18 PF13238.6 EGD99456.1 - 0.00055 20.5 0.0 0.0015 19.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_7 PF12775.7 EGD99456.1 - 0.00066 19.2 0.1 0.0026 17.3 0.1 1.9 1 1 0 1 1 1 1 P-loop containing dynein motor region TsaE PF02367.17 EGD99456.1 - 0.0011 19.0 0.0 0.019 15.0 0.0 2.4 1 1 1 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE RNA_helicase PF00910.22 EGD99456.1 - 0.0018 18.6 0.0 0.004 17.5 0.0 1.6 1 0 0 1 1 1 1 RNA helicase TIP49 PF06068.13 EGD99456.1 - 0.002 17.4 0.0 0.0038 16.5 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_14 PF13173.6 EGD99456.1 - 0.0024 17.9 0.0 0.0054 16.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain NTPase_1 PF03266.15 EGD99456.1 - 0.0038 17.2 0.0 0.015 15.2 0.0 1.9 2 0 0 2 2 2 1 NTPase AAA_30 PF13604.6 EGD99456.1 - 0.0052 16.5 0.1 0.014 15.2 0.1 1.8 1 1 0 1 1 1 1 AAA domain AAA_3 PF07726.11 EGD99456.1 - 0.0056 16.5 0.0 0.017 14.9 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.21 EGD99456.1 - 0.0074 15.7 0.0 0.017 14.5 0.0 1.6 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI NACHT PF05729.12 EGD99456.1 - 0.0075 16.2 0.3 0.11 12.4 0.0 2.6 3 0 0 3 3 2 1 NACHT domain IL11 PF07400.11 EGD99456.1 - 0.0085 15.8 0.0 0.015 14.9 0.0 1.3 1 0 0 1 1 1 1 Interleukin 11 AAA_33 PF13671.6 EGD99456.1 - 0.0089 16.2 0.0 0.02 15.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain TniB PF05621.11 EGD99456.1 - 0.0095 15.4 0.0 0.49 9.8 0.0 2.3 2 0 0 2 2 2 1 Bacterial TniB protein IstB_IS21 PF01695.17 EGD99456.1 - 0.016 14.9 0.0 0.031 14.0 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_24 PF13479.6 EGD99456.1 - 0.025 14.3 0.2 0.056 13.2 0.2 1.6 1 1 0 1 1 1 0 AAA domain AAA_11 PF13086.6 EGD99456.1 - 0.027 14.3 0.0 0.13 12.0 0.0 2.0 2 0 0 2 2 2 0 AAA domain ATPase PF06745.13 EGD99456.1 - 0.031 13.6 0.6 0.55 9.5 0.0 2.5 3 0 0 3 3 3 0 KaiC ATPase_2 PF01637.18 EGD99456.1 - 0.033 14.1 0.1 0.33 10.8 0.0 2.2 1 1 0 2 2 2 0 ATPase domain predominantly from Archaea Bac_DnaA PF00308.18 EGD99456.1 - 0.046 13.5 0.0 0.079 12.8 0.0 1.4 1 0 0 1 1 1 0 Bacterial dnaA protein AAA_25 PF13481.6 EGD99456.1 - 0.055 13.0 0.7 0.27 10.8 0.1 2.2 2 1 1 3 3 3 0 AAA domain AFG1_ATPase PF03969.16 EGD99456.1 - 0.062 12.2 0.1 0.12 11.2 0.0 1.5 2 0 0 2 2 2 0 AFG1-like ATPase Sigma54_activat PF00158.26 EGD99456.1 - 0.075 12.7 0.2 1.3 8.7 0.0 2.5 2 1 0 2 2 2 0 Sigma-54 interaction domain Zeta_toxin PF06414.12 EGD99456.1 - 0.084 12.1 0.1 0.21 10.8 0.0 1.7 2 0 0 2 2 1 0 Zeta toxin AAA_29 PF13555.6 EGD99456.1 - 0.12 12.1 0.0 0.33 10.7 0.0 1.7 2 0 0 2 2 1 0 P-loop containing region of AAA domain AAA_19 PF13245.6 EGD99456.1 - 0.13 12.6 0.1 0.37 11.1 0.1 1.7 1 0 0 1 1 1 0 AAA domain cobW PF02492.19 EGD99456.1 - 0.14 11.7 0.0 0.31 10.6 0.0 1.6 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain Parvo_NS1 PF01057.17 EGD99456.1 - 0.2 10.7 0.0 0.37 9.8 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 Asp PF00026.23 EGD99457.1 - 4.9e-109 364.6 0.4 5.9e-109 364.3 0.4 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EGD99457.1 - 5.6e-15 56.0 3.4 1.1e-12 48.6 2.0 2.8 2 1 0 2 2 2 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 EGD99457.1 - 3e-05 24.6 0.4 0.51 11.0 0.0 3.6 3 2 0 3 3 3 2 Aspartyl protease TAXi_C PF14541.6 EGD99457.1 - 0.00079 19.2 0.0 0.012 15.4 0.0 2.3 1 1 0 1 1 1 1 Xylanase inhibitor C-terminal gag-asp_proteas PF13975.6 EGD99457.1 - 0.0027 18.2 0.1 5.3 7.7 0.1 3.3 3 2 0 3 3 3 2 gag-polyprotein putative aspartyl protease NIF PF03031.18 EGD99458.1 - 2.4e-27 95.6 0.0 4.7e-27 94.7 0.0 1.4 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase BRCT PF00533.26 EGD99458.1 - 1.8e-09 37.8 0.0 7.3e-09 35.9 0.0 2.0 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 EGD99458.1 - 1.1e-07 32.1 0.3 1.8e-05 25.1 0.0 2.8 2 0 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain PTCB-BRCT PF12738.7 EGD99458.1 - 4.9e-06 26.4 0.4 1.2e-05 25.1 0.4 1.7 1 0 0 1 1 1 1 twin BRCT domain Biotin_lipoyl_2 PF13533.6 EGD99458.1 - 0.0013 18.5 0.0 1.2 9.1 0.0 2.7 2 0 0 2 2 2 2 Biotin-lipoyl like RTT107_BRCT_5 PF16770.5 EGD99458.1 - 0.0035 17.2 0.0 0.0085 15.9 0.0 1.7 1 0 0 1 1 1 1 Regulator of Ty1 transposition protein 107 BRCT domain BRCT_3 PF18428.1 EGD99458.1 - 0.0072 16.4 0.1 0.019 15.1 0.1 1.7 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain LIG3_BRCT PF16759.5 EGD99458.1 - 0.15 12.4 0.1 0.4 11.0 0.1 1.7 1 0 0 1 1 1 0 DNA ligase 3 BRCT domain MARVEL PF01284.23 EGD99460.1 - 0.00013 22.0 15.0 0.00023 21.2 14.8 1.6 1 1 0 1 1 1 1 Membrane-associating domain Arginase PF00491.21 EGD99461.1 - 9.5e-77 258.2 0.4 1.1e-76 258.0 0.4 1.0 1 0 0 1 1 1 1 Arginase family GatB_N PF02934.15 EGD99462.1 - 2.7e-95 318.9 0.0 3.5e-95 318.5 0.0 1.1 1 0 0 1 1 1 1 GatB/GatE catalytic domain GatB_Yqey PF02637.18 EGD99462.1 - 6.9e-24 84.4 0.0 1.2e-23 83.7 0.0 1.3 1 0 0 1 1 1 1 GatB domain Med11 PF10280.9 EGD99463.1 - 0.065 13.7 0.2 0.15 12.5 0.2 1.6 1 0 0 1 1 1 0 Mediator complex protein Histone_HNS PF00816.21 EGD99463.1 - 0.095 13.5 0.2 0.41 11.5 0.2 2.1 1 0 0 1 1 1 0 H-NS histone family DUF4484 PF14831.6 EGD99463.1 - 0.49 10.4 6.5 0.77 9.8 0.2 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4484) ECH_1 PF00378.20 EGD99466.1 - 3.1e-41 141.4 0.0 5.8e-41 140.5 0.0 1.4 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EGD99466.1 - 4.7e-28 98.6 0.0 6.3e-28 98.2 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Pox_P21 PF05313.12 EGD99466.1 - 0.23 11.0 0.0 0.35 10.4 0.0 1.2 1 0 0 1 1 1 0 Poxvirus P21 membrane protein NB-ARC PF00931.22 EGD99467.1 - 2.3e-07 30.3 0.0 3.3e-07 29.7 0.0 1.2 1 0 0 1 1 1 1 NB-ARC domain AAA_16 PF13191.6 EGD99467.1 - 1.8e-06 28.4 2.0 6e-05 23.5 0.0 3.5 4 1 0 4 4 4 1 AAA ATPase domain PGAP1 PF07819.13 EGD99467.1 - 3.1e-05 23.8 0.0 0.0002 21.2 0.0 2.0 1 1 1 2 2 2 1 PGAP1-like protein DUF676 PF05057.14 EGD99467.1 - 0.00065 19.3 0.2 0.0014 18.2 0.2 1.5 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Zeta_toxin PF06414.12 EGD99467.1 - 0.0061 15.9 0.0 0.014 14.7 0.0 1.5 1 0 0 1 1 1 1 Zeta toxin AAA_33 PF13671.6 EGD99467.1 - 0.012 15.8 0.0 0.04 14.1 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 EGD99467.1 - 0.013 15.8 0.0 0.044 14.1 0.0 1.9 1 0 0 1 1 1 0 AAA domain Hydrolase_4 PF12146.8 EGD99467.1 - 0.031 13.6 0.0 0.061 12.6 0.0 1.4 1 0 0 1 1 1 0 Serine aminopeptidase, S33 ATPase PF06745.13 EGD99467.1 - 0.097 12.0 0.0 0.2 11.0 0.0 1.4 1 0 0 1 1 1 0 KaiC Sigma54_activat PF00158.26 EGD99467.1 - 0.11 12.2 0.0 0.2 11.3 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain YtxH PF12732.7 EGD99469.1 - 0.79 10.3 8.9 1.9 9.1 8.9 1.7 1 1 0 1 1 1 0 YtxH-like protein Alanine_zipper PF11839.8 EGD99469.1 - 3.1 8.3 19.0 7.8 7.0 19.0 1.8 1 1 0 1 1 1 0 Alanine-zipper, major outer membrane lipoprotein FHA PF00498.26 EGD99470.1 - 2.1e-12 47.2 0.0 4.5e-12 46.2 0.0 1.6 1 0 0 1 1 1 1 FHA domain MFS_1 PF07690.16 EGD99471.1 - 8.2e-30 103.9 31.3 8.2e-30 103.9 31.3 1.6 1 1 1 2 2 2 2 Major Facilitator Superfamily Fungal_trans_2 PF11951.8 EGD99472.1 - 2.2e-33 115.6 2.2 2.9e-33 115.2 2.2 1.0 1 0 0 1 1 1 1 Fungal specific transcription factor domain DnaJ PF00226.31 EGD99473.1 - 2.9e-08 33.7 0.1 5.7e-08 32.8 0.1 1.5 1 0 0 1 1 1 1 DnaJ domain SUKH-4 PF14435.6 EGD99473.1 - 0.078 13.0 0.4 0.9 9.6 0.2 2.1 2 0 0 2 2 2 0 SUKH-4 immunity protein Abhydrolase_3 PF07859.13 EGD99474.1 - 3.3e-37 128.4 0.0 4.2e-36 124.8 0.0 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 EGD99474.1 - 0.00048 19.1 0.6 0.0036 16.2 0.6 2.3 1 1 0 1 1 1 1 Steryl acetyl hydrolase Mito_fiss_reg PF05308.11 EGD99478.1 - 0.0039 17.3 9.9 0.0074 16.4 9.9 1.4 1 0 0 1 1 1 1 Mitochondrial fission regulator M_domain PF12938.7 EGD99478.1 - 0.045 13.6 13.6 0.08 12.7 13.6 1.3 1 0 0 1 1 1 0 M domain of GW182 HMG_box PF00505.19 EGD99479.1 - 1.4e-24 86.3 0.5 2.2e-24 85.7 0.5 1.3 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EGD99479.1 - 1.5e-18 67.1 0.9 2.2e-18 66.6 0.9 1.3 1 0 0 1 1 1 1 HMG-box domain Ccdc124 PF06244.12 EGD99479.1 - 0.001 19.6 0.0 0.001 19.6 0.0 2.0 1 1 1 2 2 2 1 Coiled-coil domain-containing protein 124 /Oxs1 HMG_box_5 PF14887.6 EGD99479.1 - 0.014 15.3 0.2 0.014 15.3 0.2 1.6 2 0 0 2 2 2 0 HMG (high mobility group) box 5 CHDNT PF08073.12 EGD99479.1 - 0.042 13.8 0.0 0.066 13.2 0.0 1.3 1 0 0 1 1 1 0 CHDNT (NUC034) domain YABBY PF04690.13 EGD99479.1 - 1 9.9 3.3 0.48 11.0 0.8 1.7 1 1 1 2 2 2 0 YABBY protein p450 PF00067.22 EGD99480.1 - 1.5e-23 83.3 0.0 3.1e-23 82.3 0.0 1.5 1 1 0 1 1 1 1 Cytochrome P450 O_Spanin_T7 PF17531.2 EGD99480.1 - 0.14 12.2 0.1 0.34 11.0 0.1 1.6 1 0 0 1 1 1 0 outer-membrane spanin sub-unit Homoserine_dh PF00742.19 EGD99481.1 - 1.5e-52 178.0 0.0 1.9e-52 177.6 0.0 1.1 1 0 0 1 1 1 1 Homoserine dehydrogenase NAD_binding_3 PF03447.16 EGD99481.1 - 2.8e-13 50.6 0.0 6.5e-13 49.4 0.0 1.7 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain DUF4078 PF13300.6 EGD99482.1 - 8.5e-05 22.8 0.1 8.5e-05 22.8 0.1 3.3 3 1 0 3 3 3 1 Domain of unknown function (DUF4078) SAPS PF04499.15 EGD99482.1 - 4.1 6.1 7.3 4.6 5.9 7.3 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein HTH_Tnp_Tc3_2 PF01498.18 EGD99483.1 - 2.2e-13 50.2 0.2 4e-13 49.4 0.2 1.4 1 0 0 1 1 1 1 Transposase HTH_23 PF13384.6 EGD99483.1 - 2.9e-05 23.7 0.3 9.1e-05 22.1 0.0 2.0 2 0 0 2 2 2 1 Homeodomain-like domain Sigma70_r4_2 PF08281.12 EGD99483.1 - 0.00025 20.7 0.1 0.51 10.1 0.0 2.4 2 0 0 2 2 2 2 Sigma-70, region 4 HTH_32 PF13565.6 EGD99483.1 - 0.00026 21.5 5.1 0.0016 19.0 0.0 2.9 1 1 2 3 3 3 1 Homeodomain-like domain HTH_7 PF02796.15 EGD99483.1 - 0.00083 19.4 0.2 0.039 14.0 0.2 2.3 2 0 0 2 2 2 1 Helix-turn-helix domain of resolvase HTH_29 PF13551.6 EGD99483.1 - 0.0042 17.1 0.3 0.025 14.6 0.0 2.4 2 1 0 2 2 2 1 Winged helix-turn helix HTH_28 PF13518.6 EGD99483.1 - 0.007 16.5 0.3 0.045 13.9 0.0 2.3 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_38 PF13936.6 EGD99483.1 - 0.022 14.5 0.6 0.13 12.1 0.0 2.6 3 1 0 3 3 3 0 Helix-turn-helix domain HTH_Tnp_IS630 PF01710.16 EGD99483.1 - 0.048 13.7 0.0 0.085 12.9 0.0 1.4 1 1 0 1 1 1 0 Transposase DUF3772 PF12607.8 EGD99483.1 - 0.8 9.5 4.9 0.54 10.1 2.9 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3772) ATG11 PF10377.9 EGD99484.1 - 3.7e-45 153.1 0.1 3.7e-45 153.1 0.1 3.8 5 0 0 5 5 5 1 Autophagy-related protein 11 APG17 PF04108.12 EGD99484.1 - 5.6e-10 38.9 42.0 3e-08 33.2 0.0 4.3 3 1 0 3 3 3 2 Autophagy protein Apg17 ERM PF00769.19 EGD99484.1 - 0.0001 22.2 16.0 0.0001 22.2 16.0 5.5 4 1 0 5 5 5 1 Ezrin/radixin/moesin family Spc7 PF08317.11 EGD99484.1 - 0.00084 18.3 16.8 0.00084 18.3 16.8 6.6 5 2 2 7 7 7 3 Spc7 kinetochore protein Fez1 PF06818.15 EGD99484.1 - 0.0061 17.0 11.6 0.0061 17.0 11.6 5.6 2 1 2 4 4 4 1 Fez1 GAS PF13851.6 EGD99484.1 - 2.9 7.2 69.3 0.04 13.2 12.4 7.8 5 1 2 8 8 8 0 Growth-arrest specific micro-tubule binding CENP-H PF05837.12 EGD99485.1 - 5.4e-27 94.4 9.4 5.4e-27 94.4 9.4 2.2 2 0 0 2 2 2 1 Centromere protein H (CENP-H) SOAR PF16533.5 EGD99485.1 - 0.095 12.7 9.3 0.56 10.2 4.6 2.6 1 1 1 2 2 2 0 STIM1 Orai1-activating region Herpes_BLRF2 PF05812.12 EGD99485.1 - 0.66 10.1 7.7 3.2 7.9 1.2 2.6 3 0 0 3 3 3 0 Herpesvirus BLRF2 protein Cas_DxTHG PF09455.10 EGD99485.1 - 3.6 7.1 8.2 0.89 9.1 5.0 1.6 1 1 1 2 2 2 0 CRISPR-associated (Cas) DxTHG family Pex19 PF04614.12 EGD99487.1 - 5.1e-70 236.0 19.8 5.1e-70 236.0 19.8 2.0 1 1 1 2 2 2 1 Pex19 protein family DUF4327 PF14217.6 EGD99487.1 - 0.0012 18.9 0.0 0.0027 17.8 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4327) ASF1_hist_chap PF04729.13 EGD99488.1 - 2.7e-74 248.2 0.0 3.9e-74 247.7 0.0 1.2 1 0 0 1 1 1 1 ASF1 like histone chaperone Nop14 PF04147.12 EGD99488.1 - 2.3 6.4 23.0 2.9 6.0 23.0 1.0 1 0 0 1 1 1 0 Nop14-like family Suf PF05843.14 EGD99489.1 - 4.5e-96 322.3 0.0 4.5e-96 322.3 0.0 4.5 4 1 1 5 5 5 2 Suppressor of forked protein (Suf) TPR_14 PF13428.6 EGD99489.1 - 8.2e-05 23.1 0.9 0.041 14.7 0.0 4.2 4 0 0 4 4 4 1 Tetratricopeptide repeat HAT PF02184.16 EGD99489.1 - 0.00033 20.5 0.0 0.0014 18.6 0.0 2.1 1 0 0 1 1 1 1 HAT (Half-A-TPR) repeat TPR_16 PF13432.6 EGD99489.1 - 0.029 15.0 0.0 1.4 9.7 0.0 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat Cdh1_DBD_1 PF18196.1 EGD99489.1 - 0.044 14.1 4.5 0.11 12.9 4.5 1.6 1 0 0 1 1 1 0 Chromodomain helicase DNA-binding domain 1 Oxysterol_BP PF01237.18 EGD99490.1 - 7e-63 212.7 3.3 1e-60 205.6 3.3 2.0 1 1 0 1 1 1 1 Oxysterol-binding protein POT1 PF02765.17 EGD99490.1 - 0.043 13.7 1.4 0.47 10.3 0.0 3.0 4 0 0 4 4 4 0 Telomeric single stranded DNA binding POT1/CDC13 RTA1 PF04479.13 EGD99491.1 - 2.1e-52 177.8 9.2 2.1e-52 177.8 9.2 1.4 2 0 0 2 2 2 1 RTA1 like protein CUE PF02845.16 EGD99492.1 - 2.5e-10 39.9 0.0 4.4e-10 39.1 0.0 1.3 1 0 0 1 1 1 1 CUE domain ELK PF03789.13 EGD99492.1 - 0.0062 16.6 0.2 0.011 15.8 0.2 1.3 1 0 0 1 1 1 1 ELK domain DUF2866 PF11065.8 EGD99493.1 - 0.055 13.5 0.0 0.12 12.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2866) DUF3446 PF11928.8 EGD99494.1 - 0.013 15.8 20.4 0.028 14.7 20.4 1.6 1 0 0 1 1 1 0 Early growth response N-terminal domain SPX PF03105.19 EGD99494.1 - 0.21 11.5 2.9 0.18 11.7 2.9 1.1 1 0 0 1 1 1 0 SPX domain SR-25 PF10500.9 EGD99494.1 - 2.5 7.6 15.5 3.4 7.2 15.5 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein CDC45 PF02724.14 EGD99495.1 - 5.9 5.1 19.5 6.5 4.9 19.5 1.2 1 0 0 1 1 1 0 CDC45-like protein UCH PF00443.29 EGD99496.1 - 1.4e-36 126.3 0.2 6.7e-32 111.0 0.0 2.1 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EGD99496.1 - 4.3e-11 43.0 0.1 6.1e-10 39.2 0.1 2.3 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zinc_ribbon_4 PF13717.6 EGD99496.1 - 0.32 10.9 7.0 1.7 8.6 0.1 2.9 3 0 0 3 3 3 0 zinc-ribbon domain F_bP_aldolase PF01116.20 EGD99498.1 - 2.6e-91 306.0 0.0 3e-91 305.8 0.0 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-II FCP1_C PF09309.10 EGD99499.1 - 0.0014 18.6 9.8 0.0016 18.4 9.8 1.1 1 0 0 1 1 1 1 FCP1, C-terminal Tankyrase_bdg_C PF15327.6 EGD99499.1 - 0.0016 18.9 7.3 0.002 18.6 7.3 1.1 1 0 0 1 1 1 1 Tankyrase binding protein C terminal domain SMN PF06003.12 EGD99499.1 - 0.06 12.6 1.1 0.062 12.5 1.1 1.1 1 0 0 1 1 1 0 Survival motor neuron protein (SMN) DNA_pol_phi PF04931.13 EGD99499.1 - 0.21 9.6 9.9 0.23 9.5 9.9 1.0 1 0 0 1 1 1 0 DNA polymerase phi RNA_polI_A34 PF08208.11 EGD99499.1 - 0.44 10.6 11.7 0.61 10.2 11.7 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 CDC45 PF02724.14 EGD99499.1 - 0.45 8.8 10.6 0.54 8.5 10.6 1.0 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 EGD99499.1 - 0.57 8.9 3.5 0.67 8.7 3.5 1.0 1 0 0 1 1 1 0 Presenilin XAP5 PF04921.14 EGD99499.1 - 0.81 9.5 7.7 0.98 9.2 7.7 1.1 1 0 0 1 1 1 0 XAP5, circadian clock regulator PBP1_TM PF14812.6 EGD99499.1 - 0.97 9.8 9.1 0.94 9.9 5.3 2.0 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Myb_Cef PF11831.8 EGD99499.1 - 1.5 8.3 13.9 2.5 7.6 14.0 1.3 1 1 0 1 1 1 0 pre-mRNA splicing factor component U1snRNP70_N PF12220.8 EGD99499.1 - 9.4 7.0 13.7 7 7.4 8.0 2.1 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal E7 PF00527.18 EGD99499.1 - 9.8 6.4 12.3 3.8 7.8 7.2 2.2 2 0 0 2 2 2 0 E7 protein, Early protein RSN1_7TM PF02714.15 EGD99500.1 - 7.9e-77 258.2 24.4 1.3e-76 257.6 24.4 1.3 1 0 0 1 1 1 1 Calcium-dependent channel, 7TM region, putative phosphate PHM7_cyt PF14703.6 EGD99500.1 - 9.1e-43 146.5 0.0 1.4e-42 145.9 0.0 1.3 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter RSN1_TM PF13967.6 EGD99500.1 - 6.3e-39 133.2 0.6 6.3e-39 133.2 0.6 2.2 2 0 0 2 2 2 1 Late exocytosis, associated with Golgi transport Bradykinin PF06753.12 EGD99500.1 - 6.5 6.6 6.1 0.42 10.4 0.2 2.1 2 0 0 2 2 2 0 Bradykinin DUF3445 PF11927.8 EGD99503.1 - 2.7e-80 269.2 0.0 3.3e-80 268.9 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3445) Mid2 PF04478.12 EGD99504.1 - 0.00049 20.0 0.1 0.00094 19.0 0.1 1.5 1 0 0 1 1 1 1 Mid2 like cell wall stress sensor Podoplanin PF05808.11 EGD99504.1 - 0.0097 16.0 0.3 0.017 15.3 0.3 1.4 1 0 0 1 1 1 1 Podoplanin Pex14_N PF04695.13 EGD99504.1 - 0.016 15.9 1.9 0.016 15.9 1.9 1.5 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region SOG2 PF10428.9 EGD99504.1 - 0.065 12.4 3.5 0.072 12.3 3.5 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein EXS PF03124.14 EGD99505.1 - 3e-99 332.5 35.0 3.7e-99 332.2 35.0 1.1 1 0 0 1 1 1 1 EXS family SPX PF03105.19 EGD99505.1 - 8.5e-60 203.7 5.0 8.5e-60 203.7 5.0 1.4 2 0 0 2 2 2 1 SPX domain Ribosom_S30AE_C PF16321.5 EGD99505.1 - 0.21 11.3 1.5 0.28 10.9 0.1 1.9 2 0 0 2 2 2 0 Sigma 54 modulation/S30EA ribosomal protein C terminus HAD_2 PF13419.6 EGD99506.1 - 5.5e-17 62.4 0.0 9.7e-17 61.6 0.0 1.4 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EGD99506.1 - 4.5e-09 36.9 0.0 2.6e-07 31.1 0.0 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EGD99506.1 - 2.7e-06 27.4 0.0 2e-05 24.5 0.0 2.2 2 0 0 2 2 2 1 HAD-hyrolase-like DUF1100 PF06500.11 EGD99507.1 - 0.00077 18.4 0.0 0.0017 17.2 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1100) Zn_clus PF00172.18 EGD99508.1 - 1.9e-09 37.5 10.5 3.4e-09 36.7 10.5 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 EGD99508.1 - 0.0014 17.5 1.7 0.0019 17.1 1.7 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Multi_ubiq PF14452.6 EGD99508.1 - 0.087 13.1 0.0 0.31 11.3 0.0 1.9 1 0 0 1 1 1 0 Multiubiquitin Abhydrolase_2 PF02230.16 EGD99509.1 - 2.3e-21 76.6 0.0 2.9e-21 76.3 0.0 1.1 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Abhydrolase_6 PF12697.7 EGD99509.1 - 4.5e-06 27.4 0.2 5.6e-06 27.1 0.2 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family XylR_N PF06505.11 EGD99509.1 - 0.032 14.0 0.1 0.053 13.3 0.1 1.3 1 0 0 1 1 1 0 Activator of aromatic catabolism PDEase_I_N PF08499.12 EGD99510.1 - 0.031 14.1 0.3 0.5 10.2 0.1 2.5 1 1 1 2 2 2 0 3'5'-cyclic nucleotide phosphodiesterase N-terminal Metallophos PF00149.28 EGD99511.1 - 2.9e-37 129.1 0.6 7.3e-37 127.9 0.2 1.8 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase DUF1647 PF07801.11 EGD99511.1 - 0.11 12.2 0.6 1.7 8.3 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1647) HSP70 PF00012.20 EGD99513.1 - 8e-07 27.6 0.0 1.4e-06 26.8 0.0 1.3 1 0 0 1 1 1 1 Hsp70 protein Voldacs PF03517.13 EGD99515.1 - 2.3e-07 31.0 2.9 2.3e-07 31.0 2.9 2.1 2 0 0 2 2 2 1 Regulator of volume decrease after cellular swelling LIP PF03583.14 EGD99517.1 - 5.7e-71 239.2 0.0 7.3e-71 238.8 0.0 1.1 1 0 0 1 1 1 1 Secretory lipase Opi1 PF08618.10 EGD99520.1 - 1.8e-42 146.1 21.7 4.5e-32 111.8 6.0 3.8 2 1 2 4 4 4 3 Transcription factor Opi1 Corazonin PF17308.2 EGD99520.1 - 7.4 6.9 15.9 1.1 9.6 4.6 3.4 3 0 0 3 3 3 0 Pro-corazonin RdRP PF05183.12 EGD99521.1 - 2.7e-131 439.1 0.0 3.7e-131 438.6 0.0 1.1 1 0 0 1 1 1 1 RNA dependent RNA polymerase AA_permease PF00324.21 EGD99522.1 - 1e-126 423.4 41.3 1.2e-126 423.1 41.3 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EGD99522.1 - 2.1e-36 125.7 41.1 2.6e-36 125.4 41.1 1.1 1 0 0 1 1 1 1 Amino acid permease Gtr1_RagA PF04670.12 EGD99524.1 - 3.3e-92 308.0 0.1 4e-92 307.8 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Roc PF08477.13 EGD99524.1 - 4.8e-08 33.2 0.0 8.7e-08 32.4 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EGD99524.1 - 7.9e-08 31.9 0.0 1.2e-07 31.3 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 EGD99524.1 - 3.1e-07 30.1 0.0 4.7e-07 29.5 0.0 1.3 1 0 0 1 1 1 1 Ras family MMR_HSR1 PF01926.23 EGD99524.1 - 3.7e-07 30.2 0.0 7.6e-07 29.2 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase G-alpha PF00503.20 EGD99524.1 - 0.012 14.9 2.9 1.7 7.7 1.1 2.3 1 1 1 2 2 2 0 G-protein alpha subunit DUF815 PF05673.13 EGD99524.1 - 0.013 14.7 0.1 0.022 13.9 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_29 PF13555.6 EGD99524.1 - 0.015 15.0 0.9 0.042 13.6 0.3 2.0 2 0 0 2 2 2 0 P-loop containing region of AAA domain ABC_tran PF00005.27 EGD99524.1 - 0.016 15.7 0.0 0.034 14.7 0.0 1.5 1 0 0 1 1 1 0 ABC transporter RsgA_GTPase PF03193.16 EGD99524.1 - 0.074 12.9 0.4 0.42 10.5 0.1 2.3 3 1 1 4 4 4 0 RsgA GTPase AAA_7 PF12775.7 EGD99524.1 - 0.094 12.2 0.0 0.22 11.0 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region MMR_HSR1_Xtn PF16897.5 EGD99524.1 - 0.12 12.4 0.0 0.25 11.4 0.0 1.5 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain AIG1 PF04548.16 EGD99524.1 - 0.33 10.2 1.0 0.5 9.7 0.4 1.9 2 1 0 2 2 2 0 AIG1 family zf-RanBP PF00641.18 EGD99526.1 - 2.4e-19 68.3 8.4 7.9e-10 37.9 1.5 2.3 2 0 0 2 2 2 2 Zn-finger in Ran binding protein and others RNase_T PF00929.24 EGD99526.1 - 3.3e-07 31.0 0.0 5.6e-07 30.2 0.0 1.3 1 0 0 1 1 1 1 Exonuclease RRM_1 PF00076.22 EGD99526.1 - 8.9e-07 28.6 0.0 2.1e-06 27.5 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Cnd3 PF12719.7 EGD99527.1 - 1.1e-90 303.8 0.1 1.8e-89 299.8 0.0 2.6 2 1 0 2 2 2 1 Nuclear condensing complex subunits, C-term domain HEAT_2 PF13646.6 EGD99527.1 - 4.4e-09 36.6 3.8 4.9e-05 23.6 0.2 4.2 2 1 1 3 3 3 2 HEAT repeats HEAT_EZ PF13513.6 EGD99527.1 - 5.4e-07 30.0 2.7 0.38 11.3 0.1 5.4 4 1 0 4 4 4 2 HEAT-like repeat HEAT PF02985.22 EGD99527.1 - 7e-06 25.9 6.7 0.23 11.8 0.0 6.4 7 0 0 7 7 7 2 HEAT repeat Cnd1 PF12717.7 EGD99527.1 - 0.0029 17.6 0.1 0.11 12.5 0.0 3.4 3 1 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 RICTOR_N PF14664.6 EGD99527.1 - 0.032 13.2 0.8 0.87 8.5 0.2 2.8 2 0 0 2 2 2 0 Rapamycin-insensitive companion of mTOR, N-term MMS19_N PF14500.6 EGD99527.1 - 0.046 13.3 0.1 1.4 8.5 0.0 2.8 3 0 0 3 3 3 0 Dos2-interacting transcription regulator of RNA-Pol-II PALP PF00291.25 EGD99528.1 - 7.9e-68 229.0 0.2 9.6e-68 228.7 0.2 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Oxidored_molyb PF00174.19 EGD99529.1 - 1.2e-59 200.8 0.0 1.7e-59 200.3 0.0 1.2 1 0 0 1 1 1 1 Oxidoreductase molybdopterin binding domain Mo-co_dimer PF03404.16 EGD99529.1 - 1.1e-25 90.2 0.8 2.3e-25 89.2 0.8 1.5 1 0 0 1 1 1 1 Mo-co oxidoreductase dimerisation domain BNR PF02012.20 EGD99529.1 - 0.24 11.6 2.3 0.56 10.4 0.2 2.9 2 0 0 2 2 2 0 BNR/Asp-box repeat Tim17 PF02466.19 EGD99530.1 - 6e-39 132.8 5.6 9.4e-39 132.2 5.6 1.3 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family Romo1 PF10247.9 EGD99530.1 - 1.2 9.6 12.0 0.82 10.1 1.3 3.3 2 1 1 3 3 3 0 Reactive mitochondrial oxygen species modulator 1 DUF4048 PF13257.6 EGD99531.1 - 1.6e-80 270.6 20.7 1.6e-80 270.6 20.7 2.3 3 0 0 3 3 3 1 Domain of unknown function (DUF4048) SLATT_1 PF18181.1 EGD99531.1 - 0.077 12.9 0.7 0.16 11.9 0.7 1.4 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain 1 Bap31_Bap29_C PF18035.1 EGD99531.1 - 0.14 12.2 3.2 0.29 11.1 3.2 1.5 1 0 0 1 1 1 0 Bap31/Bap29 cytoplasmic coiled-coil domain CAP59_mtransfer PF11735.8 EGD99532.1 - 1.8e-71 240.6 0.0 2.3e-71 240.3 0.0 1.1 1 0 0 1 1 1 1 Cryptococcal mannosyltransferase 1 Cobalamin_bind PF01122.19 EGD99536.1 - 0.095 11.6 0.1 0.14 11.1 0.1 1.1 1 0 0 1 1 1 0 Eukaryotic cobalamin-binding protein Pkinase PF00069.25 EGD99538.1 - 2.3e-70 237.0 0.0 3.1e-70 236.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD99538.1 - 1.2e-47 162.4 0.0 1.8e-47 161.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EGD99538.1 - 1.2e-05 24.3 0.0 3.4e-05 22.8 0.0 1.7 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 EGD99538.1 - 0.00016 21.1 0.0 0.0032 16.8 0.0 2.3 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 EGD99538.1 - 0.032 14.2 0.1 6.5 6.6 0.0 2.8 2 1 1 3 3 3 0 Phosphotransferase enzyme family ABC1 PF03109.16 EGD99538.1 - 0.17 12.1 0.0 0.42 10.8 0.0 1.6 1 0 0 1 1 1 0 ABC1 family FAD-oxidase_C PF02913.19 EGD99539.1 - 7.6e-63 212.5 0.0 1.1e-62 212.0 0.0 1.2 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 EGD99539.1 - 1.1e-35 122.4 0.4 2.2e-35 121.4 0.4 1.5 1 0 0 1 1 1 1 FAD binding domain Aldo_ket_red PF00248.21 EGD99540.1 - 2e-52 178.2 0.0 1.1e-51 175.8 0.0 1.8 1 1 0 1 1 1 1 Aldo/keto reductase family Peptidase_M19 PF01244.21 EGD99540.1 - 0.11 11.7 0.0 0.89 8.7 0.0 2.1 2 0 0 2 2 2 0 Membrane dipeptidase (Peptidase family M19) Proteasome PF00227.26 EGD99541.1 - 9.6e-53 178.5 0.1 1.2e-52 178.1 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EGD99541.1 - 2.6e-07 30.2 0.3 1.2e-06 28.1 0.1 2.2 2 1 0 2 2 2 1 Proteasome subunit A N-terminal signature ERG4_ERG24 PF01222.17 EGD99543.1 - 7.3e-148 492.9 9.8 8.3e-148 492.7 9.8 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family DUF1295 PF06966.12 EGD99543.1 - 6.1e-05 22.7 0.1 0.00019 21.0 0.1 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) BBS2_Mid PF14783.6 EGD99544.1 - 0.2 11.7 0.1 0.59 10.2 0.0 1.8 2 0 0 2 2 2 0 Ciliary BBSome complex subunit 2, middle region PQQ_3 PF13570.6 EGD99544.1 - 4.1 8.0 8.9 3.5 8.2 0.0 3.7 4 0 0 4 4 4 0 PQQ-like domain FMO-like PF00743.19 EGD99545.1 - 5.3e-18 64.7 0.3 4.6e-16 58.3 0.1 3.0 2 1 1 3 3 3 1 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.14 EGD99545.1 - 8.1e-05 22.0 0.0 0.0082 15.4 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EGD99545.1 - 0.00011 21.4 0.0 0.0018 17.5 0.0 2.2 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 EGD99545.1 - 0.00015 21.9 0.3 0.00057 20.1 0.0 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 EGD99545.1 - 0.0029 16.9 0.2 0.058 12.6 0.0 2.5 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase GCR1_C PF12550.8 EGD99545.1 - 0.063 13.6 1.6 0.34 11.3 0.1 2.6 2 0 0 2 2 2 0 Transcriptional activator of glycolytic enzymes APH PF01636.23 EGD99546.1 - 1.1e-19 71.3 0.0 1.5e-19 70.9 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EGD99546.1 - 1.1e-05 25.2 0.0 1.7e-05 24.5 0.0 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase Pkinase PF00069.25 EGD99546.1 - 0.0012 18.2 0.0 0.16 11.3 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain RIO1 PF01163.22 EGD99546.1 - 0.0035 17.0 0.0 0.17 11.5 0.0 2.2 2 0 0 2 2 2 1 RIO1 family Fructosamin_kin PF03881.14 EGD99546.1 - 0.0047 16.2 0.1 0.12 11.5 0.0 2.1 2 0 0 2 2 2 1 Fructosamine kinase Kdo PF06293.14 EGD99546.1 - 0.015 14.7 0.0 0.84 8.9 0.0 2.4 2 1 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_Tyr PF07714.17 EGD99546.1 - 0.07 12.4 0.0 0.6 9.3 0.0 2.0 1 1 0 1 1 1 0 Protein tyrosine kinase DUF1679 PF07914.11 EGD99546.1 - 0.16 10.8 0.0 0.57 9.0 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1679) UPF0047 PF01894.17 EGD99548.1 - 3.2e-38 130.4 0.0 3.6e-38 130.3 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family UPF0047 GFA PF04828.14 EGD99549.1 - 4e-05 23.9 3.0 0.00069 19.9 3.0 2.3 1 1 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme ECH_1 PF00378.20 EGD99550.1 - 8.8e-51 172.6 0.0 1.2e-50 172.2 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EGD99550.1 - 4.6e-23 82.2 0.0 1e-22 81.1 0.0 1.6 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase LPD15 PF18828.1 EGD99550.1 - 0.096 12.6 0.0 0.18 11.7 0.0 1.4 1 0 0 1 1 1 0 Large polyvalent-protein-associated domain 15 zf-CHCC PF10276.9 EGD99551.1 - 1.4e-15 57.0 2.1 2.3e-15 56.3 2.1 1.4 1 0 0 1 1 1 1 Zinc-finger domain MPP6 PF10175.9 EGD99552.1 - 8.3e-05 23.1 8.2 0.0028 18.2 8.2 2.5 1 1 0 1 1 1 1 M-phase phosphoprotein 6 Dscam_C PF12355.8 EGD99552.1 - 0.21 12.5 0.4 0.21 12.5 0.4 2.5 1 1 0 2 2 2 0 Down syndrome cell adhesion molecule C terminal CoaE PF01121.20 EGD99553.1 - 1.8e-42 145.0 0.0 2.5e-42 144.6 0.0 1.1 1 0 0 1 1 1 1 Dephospho-CoA kinase AAA_18 PF13238.6 EGD99553.1 - 0.011 16.3 0.1 0.2 12.2 0.0 2.3 2 0 0 2 2 2 0 AAA domain 2TM PF13239.6 EGD99553.1 - 0.035 14.4 0.1 0.035 14.4 0.1 1.6 2 0 0 2 2 2 0 2TM domain NUDIX_2 PF13869.6 EGD99554.1 - 8.2e-61 204.9 0.0 5.4e-46 156.6 0.0 2.0 1 1 1 2 2 2 2 Nucleotide hydrolase APH PF01636.23 EGD99555.1 - 1.9e-11 44.4 0.0 3.4e-11 43.5 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Peptidase_M16_M PF16187.5 EGD99556.1 - 1.9e-98 329.2 0.1 2.9e-98 328.6 0.1 1.3 1 0 0 1 1 1 1 Middle or third domain of peptidase_M16 Peptidase_M16_C PF05193.21 EGD99556.1 - 8.6e-36 123.7 0.3 5.9e-23 81.8 0.0 3.8 4 0 0 4 4 4 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 EGD99556.1 - 9e-33 113.4 2.1 1.4e-21 77.1 0.3 4.0 4 0 0 4 4 4 2 Insulinase (Peptidase family M16) DUF386 PF04074.12 EGD99557.1 - 0.14 12.1 0.0 0.2 11.5 0.0 1.2 1 0 0 1 1 1 0 YhcH/YjgK/YiaL MFS_1 PF07690.16 EGD99559.1 - 1.6e-33 116.1 39.2 1.6e-33 116.1 39.2 1.6 1 1 1 2 2 2 1 Major Facilitator Superfamily YesK PF14150.6 EGD99559.1 - 0.33 11.2 0.2 0.33 11.2 0.2 4.1 5 0 0 5 5 5 0 YesK-like protein TraL PF07178.11 EGD99559.1 - 2 8.9 0.0 2 8.9 0.0 4.1 4 1 1 6 6 6 0 TraL protein Sugar_tr PF00083.24 EGD99560.1 - 5.5e-94 315.6 16.3 3.6e-87 293.1 9.4 2.0 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 EGD99560.1 - 1.2e-18 67.2 20.0 6.2e-18 64.9 16.5 2.5 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EGD99560.1 - 0.0097 14.4 1.5 0.01 14.3 0.5 1.5 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) MFS_3 PF05977.13 EGD99560.1 - 0.085 11.2 3.0 0.082 11.3 1.1 1.7 1 1 1 2 2 2 0 Transmembrane secretion effector MFS_1_like PF12832.7 EGD99560.1 - 0.31 9.8 8.5 0.7 8.7 3.0 2.9 3 1 0 3 3 3 0 MFS_1 like family DUF2207 PF09972.9 EGD99560.1 - 1.3 7.7 4.8 3.6 6.2 4.8 1.7 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Arb2 PF09757.9 EGD99561.1 - 1.2e-99 332.7 5.1 1.6e-99 332.2 5.1 1.2 1 0 0 1 1 1 1 Arb2 domain Hist_deacetyl PF00850.19 EGD99561.1 - 3.2e-86 289.6 0.1 2.6e-85 286.6 0.0 2.0 2 0 0 2 2 2 1 Histone deacetylase domain DUF1957 PF09210.11 EGD99561.1 - 0.094 13.1 0.1 0.39 11.1 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1957) Gp_dh_C PF02800.20 EGD99562.1 - 4e-71 237.7 0.0 6.4e-71 237.1 0.0 1.3 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.24 EGD99562.1 - 1.4e-38 131.3 0.2 3.6e-38 130.0 0.1 1.7 2 0 0 2 2 2 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain DapB_N PF01113.20 EGD99562.1 - 0.0031 17.6 0.0 0.01 16.0 0.0 2.0 1 1 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus 2-Hacid_dh_C PF02826.19 EGD99562.1 - 0.076 12.4 0.0 0.21 10.9 0.0 1.7 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain GFO_IDH_MocA PF01408.22 EGD99562.1 - 0.089 13.6 0.0 6.3 7.6 0.0 2.5 2 0 0 2 2 2 0 Oxidoreductase family, NAD-binding Rossmann fold Pho88 PF10032.9 EGD99564.1 - 1.1e-77 259.4 0.6 1.2e-77 259.2 0.6 1.0 1 0 0 1 1 1 1 Phosphate transport (Pho88) DUF4512 PF14975.6 EGD99564.1 - 0.077 13.8 0.3 0.3 11.9 0.1 2.0 2 1 0 2 2 2 0 Domain of unknown function (DUF4512) Histone PF00125.24 EGD99565.1 - 8.2e-16 58.6 0.0 1e-15 58.2 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Histone_H2A_C PF16211.5 EGD99565.1 - 5.7e-12 45.2 0.0 9.3e-12 44.5 0.0 1.4 1 0 0 1 1 1 1 C-terminus of histone H2A CBFD_NFYB_HMF PF00808.23 EGD99565.1 - 0.00026 21.2 0.0 0.00037 20.7 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone HSF_DNA-bind PF00447.17 EGD99567.1 - 2.4e-29 101.8 0.3 5.6e-29 100.6 0.3 1.7 1 0 0 1 1 1 1 HSF-type DNA-binding Ets PF00178.22 EGD99567.1 - 0.047 14.2 0.0 0.11 12.9 0.0 1.6 1 0 0 1 1 1 0 Ets-domain TMF_DNA_bd PF12329.8 EGD99567.1 - 0.21 11.6 0.1 0.21 11.6 0.1 3.1 3 0 0 3 3 3 0 TATA element modulatory factor 1 DNA binding R3H PF01424.22 EGD99570.1 - 9.1e-10 38.4 0.0 1.9e-09 37.4 0.0 1.6 1 0 0 1 1 1 1 R3H domain RRM_1 PF00076.22 EGD99570.1 - 1.4e-05 24.8 0.1 2.9e-05 23.8 0.1 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CAS_C PF12026.8 EGD99570.1 - 0.3 11.1 1.5 0.49 10.4 1.5 1.3 1 0 0 1 1 1 0 Crk-Associated Substrate C-terminal domain SUIM_assoc PF16619.5 EGD99570.1 - 1.3 9.1 10.8 0.25 11.4 1.1 3.0 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Pro_isomerase PF00160.21 EGD99571.1 - 7.2e-38 130.3 0.0 1.1e-37 129.8 0.0 1.3 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD XAP5 PF04921.14 EGD99571.1 - 0.07 12.9 1.1 0.1 12.4 1.1 1.2 1 0 0 1 1 1 0 XAP5, circadian clock regulator His_Phos_2 PF00328.22 EGD99572.1 - 5.4e-09 35.9 0.0 2e-07 30.8 0.0 2.1 1 1 1 2 2 2 2 Histidine phosphatase superfamily (branch 2) Peptidase_M19 PF01244.21 EGD99573.1 - 3.5e-104 348.4 0.0 4.1e-104 348.2 0.0 1.0 1 0 0 1 1 1 1 Membrane dipeptidase (Peptidase family M19) AAA PF00004.29 EGD99574.1 - 1.6e-16 60.9 0.3 3.1e-16 60.0 0.0 1.6 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) Rep_fac_C PF08542.11 EGD99574.1 - 1e-15 57.9 0.0 4.4e-15 55.9 0.0 2.2 3 0 0 3 3 1 1 Replication factor C C-terminal domain DNA_pol3_delta2 PF13177.6 EGD99574.1 - 1.8e-12 47.4 0.0 8.8e-12 45.1 0.0 2.0 1 1 0 1 1 1 1 DNA polymerase III, delta subunit Rad17 PF03215.15 EGD99574.1 - 7.9e-09 35.7 0.0 1.4e-08 34.9 0.0 1.5 1 1 0 1 1 1 1 Rad17 P-loop domain AAA_assoc_2 PF16193.5 EGD99574.1 - 3.1e-08 33.8 0.0 1.8e-07 31.4 0.0 2.2 2 0 0 2 2 2 1 AAA C-terminal domain AAA_30 PF13604.6 EGD99574.1 - 1.4e-06 28.1 0.0 2.8e-06 27.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EGD99574.1 - 3.6e-06 27.5 0.0 5.2e-05 23.7 0.0 2.3 1 1 0 1 1 1 1 AAA ATPase domain DNA_pol3_delta PF06144.13 EGD99574.1 - 5.1e-06 26.4 0.0 1e-05 25.4 0.0 1.4 1 0 0 1 1 1 1 DNA polymerase III, delta subunit AAA_11 PF13086.6 EGD99574.1 - 5.2e-06 26.4 0.0 9.5e-06 25.6 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.14 EGD99574.1 - 1.5e-05 25.0 0.2 6.2e-05 23.0 0.1 2.2 2 1 0 2 2 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EGD99574.1 - 1.7e-05 25.1 0.3 0.00015 22.0 0.1 2.5 2 1 0 2 2 2 1 AAA domain DUF815 PF05673.13 EGD99574.1 - 9.6e-05 21.7 0.0 0.00018 20.8 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) RuvB_N PF05496.12 EGD99574.1 - 0.00012 21.8 0.0 0.00033 20.5 0.0 1.7 2 0 0 2 2 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_24 PF13479.6 EGD99574.1 - 0.00028 20.7 0.0 0.00052 19.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_3 PF07726.11 EGD99574.1 - 0.00028 20.8 0.0 0.00095 19.0 0.0 2.0 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ResIII PF04851.15 EGD99574.1 - 0.00083 19.4 0.0 0.086 12.8 0.0 2.4 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 EGD99574.1 - 0.00097 19.5 0.0 0.0024 18.2 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_14 PF13173.6 EGD99574.1 - 0.001 19.1 0.0 0.0028 17.7 0.0 1.7 1 1 1 2 2 2 1 AAA domain Sigma54_activat PF00158.26 EGD99574.1 - 0.0024 17.6 0.0 0.0063 16.2 0.0 1.6 2 0 0 2 2 1 1 Sigma-54 interaction domain PhoH PF02562.16 EGD99574.1 - 0.0031 17.0 0.2 0.61 9.5 0.0 2.3 1 1 0 2 2 2 1 PhoH-like protein DEAD PF00270.29 EGD99574.1 - 0.0064 16.3 0.0 0.036 13.9 0.1 2.1 1 1 1 2 2 2 1 DEAD/DEAH box helicase AAA_18 PF13238.6 EGD99574.1 - 0.0077 16.8 0.0 0.013 16.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.6 EGD99574.1 - 0.015 15.5 0.0 0.034 14.4 0.0 1.6 1 1 0 1 1 1 0 AAA domain TniB PF05621.11 EGD99574.1 - 0.024 14.0 0.0 0.16 11.4 0.0 2.1 2 0 0 2 2 2 0 Bacterial TniB protein AAA_7 PF12775.7 EGD99574.1 - 0.025 14.1 0.0 0.05 13.1 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region Mg_chelatase PF01078.21 EGD99574.1 - 0.05 13.0 0.2 0.26 10.6 0.1 2.2 1 1 1 2 2 2 0 Magnesium chelatase, subunit ChlI DUF2075 PF09848.9 EGD99574.1 - 0.057 12.6 0.0 0.11 11.8 0.0 1.4 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_25 PF13481.6 EGD99574.1 - 0.057 13.0 0.0 0.15 11.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain MiaE PF06175.11 EGD99574.1 - 0.059 13.0 0.0 0.1 12.2 0.0 1.3 1 0 0 1 1 1 0 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE) RNA_helicase PF00910.22 EGD99574.1 - 0.069 13.5 0.0 0.19 12.2 0.0 1.8 1 0 0 1 1 1 0 RNA helicase ATPase_2 PF01637.18 EGD99574.1 - 0.092 12.6 0.0 0.16 11.8 0.0 1.4 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea Cullin_Nedd8 PF10557.9 EGD99574.1 - 0.11 12.5 0.3 20 5.3 0.0 3.2 3 0 0 3 3 3 0 Cullin protein neddylation domain P21-Arc PF04062.14 EGD99575.1 - 2.2e-75 252.5 0.0 2.5e-75 252.3 0.0 1.0 1 0 0 1 1 1 1 ARP2/3 complex ARPC3 (21 kDa) subunit Hormone_3 PF00159.18 EGD99575.1 - 0.066 13.3 0.1 0.12 12.4 0.1 1.5 1 0 0 1 1 1 0 Pancreatic hormone peptide NmrA PF05368.13 EGD99576.1 - 6.8e-17 61.8 0.0 8.7e-17 61.4 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EGD99576.1 - 1.7e-16 60.6 0.1 2.7e-16 60.0 0.1 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EGD99576.1 - 1.2e-06 28.2 0.1 1.8e-06 27.6 0.1 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family DapB_N PF01113.20 EGD99576.1 - 1.6e-06 28.2 0.2 3e-06 27.4 0.2 1.4 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus Semialdhyde_dh PF01118.24 EGD99576.1 - 1.4e-05 25.5 0.0 2.7e-05 24.6 0.0 1.5 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain 3Beta_HSD PF01073.19 EGD99576.1 - 7.9e-05 21.8 0.1 0.00011 21.3 0.1 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family TrkA_N PF02254.18 EGD99576.1 - 0.00042 20.6 0.5 0.00098 19.4 0.5 1.6 2 0 0 2 2 1 1 TrkA-N domain ApbA PF02558.16 EGD99576.1 - 0.0017 18.0 0.1 0.0025 17.5 0.1 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA Shikimate_DH PF01488.20 EGD99576.1 - 0.0026 17.8 0.4 0.0041 17.2 0.4 1.3 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase NAD_binding_4 PF07993.12 EGD99576.1 - 0.0033 16.6 0.0 0.0054 15.9 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein Polysacc_synt_2 PF02719.15 EGD99576.1 - 0.012 14.8 0.1 0.015 14.4 0.1 1.1 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Gp_dh_N PF00044.24 EGD99576.1 - 0.037 14.4 0.0 0.067 13.5 0.0 1.6 1 0 0 1 1 1 0 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain RmlD_sub_bind PF04321.17 EGD99576.1 - 0.043 12.9 0.1 0.065 12.3 0.1 1.3 1 0 0 1 1 1 0 RmlD substrate binding domain KR PF08659.10 EGD99576.1 - 0.046 13.6 0.1 0.078 12.9 0.1 1.3 1 0 0 1 1 1 0 KR domain GDP_Man_Dehyd PF16363.5 EGD99576.1 - 0.047 13.1 0.0 0.062 12.7 0.0 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase GFO_IDH_MocA PF01408.22 EGD99576.1 - 0.051 14.4 0.5 0.11 13.3 0.2 1.7 2 0 0 2 2 2 0 Oxidoreductase family, NAD-binding Rossmann fold CoA_binding PF02629.19 EGD99576.1 - 0.18 12.5 0.8 0.78 10.5 1.1 1.9 2 0 0 2 2 1 0 CoA binding domain Pkinase PF00069.25 EGD99577.1 - 0.23 10.8 0.0 0.4 10.0 0.0 1.4 1 0 0 1 1 1 0 Protein kinase domain APH PF01636.23 EGD99578.1 - 1.1e-08 35.4 0.0 2.6e-06 27.6 0.0 2.3 2 0 0 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 EGD99578.1 - 0.023 14.1 0.0 0.56 9.5 0.0 2.7 3 0 0 3 3 3 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.25 EGD99579.1 - 4.1e-12 46.0 0.0 4.8e-11 42.5 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD99579.1 - 3.8e-06 26.4 0.0 0.00014 21.2 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EGD99579.1 - 0.0013 18.1 0.0 0.0025 17.2 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Peptidase_M35 PF02102.15 EGD99580.1 - 9.8e-102 340.5 14.5 1.1e-101 340.3 14.5 1.0 1 0 0 1 1 1 1 Deuterolysin metalloprotease (M35) family Aspzincin_M35 PF14521.6 EGD99580.1 - 2.9e-41 141.4 3.4 2.9e-41 141.4 3.4 1.6 2 0 0 2 2 2 1 Lysine-specific metallo-endopeptidase HRXXH PF13933.6 EGD99580.1 - 0.0047 16.5 3.6 0.017 14.7 3.6 1.8 1 1 0 1 1 1 1 Putative peptidase family DUF468 PF04318.12 EGD99581.1 - 0.025 15.3 0.1 0.057 14.1 0.0 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF468) NatB_MDM20 PF09797.9 EGD99585.1 - 0.016 14.1 0.1 0.02 13.9 0.1 1.1 1 0 0 1 1 1 0 N-acetyltransferase B complex (NatB) non catalytic subunit Aldo_ket_red PF00248.21 EGD99587.1 - 1.4e-33 116.3 0.0 5.7e-33 114.4 0.0 1.7 1 1 1 2 2 2 1 Aldo/keto reductase family Rsd_AlgQ PF04353.13 EGD99587.1 - 0.024 14.6 0.1 0.042 13.8 0.1 1.3 1 0 0 1 1 1 0 Regulator of RNA polymerase sigma(70) subunit, Rsd/AlgQ CDC45 PF02724.14 EGD99588.1 - 5.4 5.2 21.4 2.7 6.2 6.8 2.2 2 0 0 2 2 2 0 CDC45-like protein Ribosomal_S19e PF01090.19 EGD99589.1 - 2.9e-51 172.8 0.4 4.3e-50 169.0 0.4 2.0 1 1 0 1 1 1 1 Ribosomal protein S19e Abhydrolase_1 PF00561.20 EGD99590.1 - 1.9e-13 50.7 0.1 4.1e-12 46.3 0.1 2.2 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EGD99590.1 - 7.9e-13 49.5 1.9 1.9e-12 48.3 1.8 1.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EGD99590.1 - 5.1e-12 45.6 0.0 2e-11 43.6 0.0 1.8 1 1 0 1 1 1 1 Serine aminopeptidase, S33 DSPc PF00782.20 EGD99590.1 - 7.1e-07 29.1 0.0 1.5e-06 28.1 0.0 1.6 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain LIDHydrolase PF10230.9 EGD99590.1 - 0.00067 19.3 0.0 0.0011 18.6 0.0 1.2 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase Ser_hydrolase PF06821.13 EGD99590.1 - 0.001 18.9 0.1 0.0021 17.9 0.1 1.4 1 0 0 1 1 1 1 Serine hydrolase PGAP1 PF07819.13 EGD99590.1 - 0.0018 18.1 0.1 0.0073 16.1 0.0 1.9 2 0 0 2 2 2 1 PGAP1-like protein Y_phosphatase PF00102.27 EGD99590.1 - 0.0083 15.7 0.0 0.035 13.7 0.0 2.0 3 0 0 3 3 3 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 EGD99590.1 - 0.011 15.9 0.0 0.019 15.1 0.0 1.4 1 0 0 1 1 1 0 Inositol hexakisphosphate Thioesterase PF00975.20 EGD99590.1 - 0.023 14.8 0.2 0.049 13.7 0.2 1.5 1 0 0 1 1 1 0 Thioesterase domain LCAT PF02450.15 EGD99590.1 - 0.1 11.8 0.0 0.16 11.1 0.0 1.2 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase DUF900 PF05990.12 EGD99590.1 - 0.13 11.8 0.0 0.22 11.0 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) Y_phosphatase3 PF13350.6 EGD99590.1 - 0.23 11.4 0.0 0.4 10.6 0.0 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family ILVD_EDD PF00920.21 EGD99591.1 - 9.9e-210 697.5 2.2 1.1e-209 697.3 2.2 1.0 1 0 0 1 1 1 1 Dehydratase family DUF1610 PF07754.11 EGD99591.1 - 0.075 13.0 0.2 22 5.1 0.2 4.0 4 0 0 4 4 4 0 Domain of unknown function (DUF1610) DUF1772 PF08592.11 EGD99592.1 - 1.9e-29 102.7 1.5 2.6e-29 102.3 1.5 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1772) Pex2_Pex12 PF04757.14 EGD99593.1 - 4.4e-35 121.3 1.0 6e-35 120.9 1.0 1.1 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-C3HC4 PF00097.25 EGD99593.1 - 0.024 14.5 2.5 0.062 13.2 2.5 1.7 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EGD99593.1 - 0.029 14.5 5.6 0.029 14.5 5.6 2.1 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.6 EGD99593.1 - 0.047 13.7 6.6 0.25 11.4 6.6 2.1 1 1 0 1 1 1 0 RING-type zinc-finger zf-C3HC4_2 PF13923.6 EGD99593.1 - 0.68 9.8 6.2 1 9.2 1.9 2.4 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EGD99593.1 - 1.2 9.6 8.5 5.4 7.4 4.3 2.4 2 0 0 2 2 2 0 Ring finger domain IBN_N PF03810.19 EGD99594.1 - 5.6e-14 51.8 0.0 2.7e-13 49.6 0.0 2.3 1 0 0 1 1 1 1 Importin-beta N-terminal domain Xpo1 PF08389.12 EGD99594.1 - 0.00096 19.2 1.8 0.012 15.6 0.0 3.3 3 1 1 4 4 4 1 Exportin 1-like protein DUF3385 PF11865.8 EGD99594.1 - 0.0055 16.6 0.3 0.023 14.6 0.3 2.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3385) Cellulase PF00150.18 EGD99595.1 - 1e-14 54.6 0.1 1e-14 54.6 0.1 1.8 2 1 0 2 2 2 1 Cellulase (glycosyl hydrolase family 5) GST_N_3 PF13417.6 EGD99596.1 - 1.5e-10 41.3 0.1 1.3e-09 38.3 0.1 2.2 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EGD99596.1 - 8.7e-08 32.4 0.0 1e-06 29.0 0.0 2.3 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EGD99596.1 - 1.7e-06 28.0 0.1 3.4e-06 27.0 0.1 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EGD99596.1 - 0.007 16.6 0.0 0.014 15.6 0.0 1.6 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GPI-anchored PF10342.9 EGD99597.1 - 5.1e-25 88.0 0.0 1e-24 87.1 0.0 1.5 1 0 0 1 1 1 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family Glyco_transf_90 PF05686.12 EGD99598.1 - 1e-36 126.8 4.7 2.9e-36 125.2 4.7 1.6 1 1 0 1 1 1 1 Glycosyl transferase family 90 Glyco_trans_1_2 PF13524.6 EGD99598.1 - 0.033 14.6 0.0 0.076 13.4 0.0 1.6 1 0 0 1 1 1 0 Glycosyl transferases group 1 CYSTM PF12734.7 EGD99601.1 - 3.4 8.1 21.5 1.8e+04 -4.1 21.5 2.6 1 1 0 1 1 1 0 Cysteine-rich TM module stress tolerance DUF16 PF01519.16 EGD99602.1 - 0.002 18.6 4.9 0.0047 17.4 4.9 1.6 1 0 0 1 1 1 1 Protein of unknown function DUF16 DUF501 PF04417.12 EGD99602.1 - 7.1 6.4 6.0 3.4 7.5 2.9 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF501) Gly_transf_sug PF04488.15 EGD99603.1 - 8.5e-11 42.4 0.0 2.4e-10 40.9 0.0 1.8 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif Caps_synth PF05704.12 EGD99603.1 - 0.028 13.8 0.0 0.028 13.8 0.0 2.1 2 0 0 2 2 2 0 Capsular polysaccharide synthesis protein RNA_polI_A34 PF08208.11 EGD99603.1 - 0.043 13.9 15.4 0.086 12.9 15.4 1.5 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 Borrelia_P83 PF05262.11 EGD99603.1 - 0.13 10.7 13.5 0.18 10.3 13.5 1.2 1 0 0 1 1 1 0 Borrelia P83/100 protein RR_TM4-6 PF06459.12 EGD99603.1 - 0.15 11.8 12.7 0.3 10.9 12.7 1.5 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 TcdA_TcdB PF12919.7 EGD99603.1 - 0.59 9.4 0.0 0.59 9.4 0.0 3.0 3 0 0 3 3 3 0 TcdA/TcdB catalytic glycosyltransferase domain Connexin PF00029.19 EGD99603.1 - 1.4 8.6 4.7 2.8 7.6 4.7 1.5 1 0 0 1 1 1 0 Connexin PTPRCAP PF15713.5 EGD99603.1 - 3.4 7.9 17.9 6.5 7.0 17.9 1.3 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated Hid1 PF12722.7 EGD99603.1 - 3.6 5.6 6.3 4.8 5.2 6.3 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Neur_chan_memb PF02932.16 EGD99603.1 - 4.6 7.2 6.3 10 6.1 6.3 1.5 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF2462 PF09495.10 EGD99604.1 - 1.7e-23 83.1 12.0 1.7e-23 83.1 12.0 1.5 1 1 1 2 2 2 1 Protein of unknown function (DUF2462) DUF5427 PF10310.9 EGD99605.1 - 4.3e-168 560.1 0.0 5.3e-168 559.8 0.0 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5427) Flu_M1_C PF08289.11 EGD99605.1 - 0.034 14.4 0.2 0.1 12.8 0.2 1.8 1 0 0 1 1 1 0 Influenza Matrix protein (M1) C-terminal domain Pex14_N PF04695.13 EGD99605.1 - 1.1 9.9 9.2 0.99 10.1 6.6 2.1 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region HA2 PF04408.23 EGD99607.1 - 1.7e-20 73.3 0.0 1.7e-20 73.3 0.0 3.0 3 0 0 3 3 3 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 EGD99607.1 - 4.9e-17 62.1 0.0 1.8e-16 60.2 0.0 2.0 2 0 0 2 2 2 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 EGD99607.1 - 7.4e-15 55.3 0.0 2.1e-14 53.8 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 EGD99607.1 - 4.2e-06 26.6 0.2 9.8e-06 25.4 0.2 1.6 1 1 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 EGD99607.1 - 0.00013 22.3 0.1 0.00039 20.7 0.1 1.7 1 0 0 1 1 1 1 AAA domain DUF2075 PF09848.9 EGD99607.1 - 0.00022 20.6 0.0 0.00045 19.6 0.0 1.5 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) T2SSE PF00437.20 EGD99607.1 - 0.0006 19.0 0.0 0.0038 16.3 0.0 2.1 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_30 PF13604.6 EGD99607.1 - 0.0013 18.5 0.0 0.0035 17.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EGD99607.1 - 0.0048 17.2 0.1 0.012 16.0 0.1 1.6 1 0 0 1 1 1 1 AAA domain ATPase PF06745.13 EGD99607.1 - 0.0079 15.6 0.0 0.016 14.5 0.0 1.5 1 0 0 1 1 1 1 KaiC SRP54 PF00448.22 EGD99607.1 - 0.01 15.5 0.2 0.032 13.9 0.2 1.9 1 1 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_14 PF13173.6 EGD99607.1 - 0.015 15.3 0.1 0.076 13.1 0.1 2.1 1 1 0 1 1 1 0 AAA domain ResIII PF04851.15 EGD99607.1 - 0.028 14.4 0.0 10 6.1 0.0 2.6 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit Flavi_DEAD PF07652.14 EGD99607.1 - 0.059 13.3 0.0 0.12 12.4 0.0 1.5 1 0 0 1 1 1 0 Flavivirus DEAD domain Glug PF07581.12 EGD99607.1 - 0.085 13.3 0.0 0.3 11.6 0.0 1.9 1 0 0 1 1 1 0 The GLUG motif Microtub_bd PF16796.5 EGD99607.1 - 0.098 12.6 0.0 0.58 10.1 0.0 2.2 2 0 0 2 2 2 0 Microtubule binding NACHT PF05729.12 EGD99607.1 - 0.17 11.8 0.8 1.4 8.9 0.1 2.4 3 0 0 3 3 3 0 NACHT domain AAA_23 PF13476.6 EGD99607.1 - 7.6 7.0 8.1 2.5 8.6 0.1 3.0 2 1 1 3 3 3 0 AAA domain DAD PF02109.16 EGD99608.1 - 1.1e-45 154.4 0.2 1.5e-45 154.0 0.2 1.2 1 0 0 1 1 1 1 DAD family Tmemb_14 PF03647.13 EGD99609.1 - 8.2e-21 74.5 7.6 1.3e-20 73.9 7.6 1.3 1 0 0 1 1 1 1 Transmembrane proteins 14C RTC4 PF14474.6 EGD99610.1 - 8.2e-33 113.1 0.0 1.7e-32 112.2 0.0 1.5 1 0 0 1 1 1 1 RTC4-like domain DUF726 PF05277.12 EGD99611.1 - 2e-127 424.8 2.9 2e-127 424.8 2.9 1.4 2 0 0 2 2 2 1 Protein of unknown function (DUF726) NUDIX PF00293.28 EGD99612.1 - 1.7e-05 24.9 0.1 3.2e-05 24.0 0.1 1.6 1 1 0 1 1 1 1 NUDIX domain Baculo_PP31 PF05311.11 EGD99612.1 - 0.19 11.2 0.0 0.25 10.8 0.0 1.2 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) Metallophos PF00149.28 EGD99613.1 - 1.2e-12 48.7 0.1 2.1e-12 48.0 0.1 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EGD99613.1 - 1.3e-06 28.7 0.1 2.1e-05 24.8 0.1 2.2 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos_3 PF14582.6 EGD99613.1 - 0.069 12.5 0.0 0.14 11.4 0.0 1.4 1 0 0 1 1 1 0 Metallophosphoesterase, calcineurin superfamily Mito_carr PF00153.27 EGD99614.1 - 1.6e-73 242.7 0.3 4.3e-25 87.5 0.0 3.4 3 0 0 3 3 3 3 Mitochondrial carrier protein EF-hand_7 PF13499.6 EGD99614.1 - 2.1e-13 50.5 6.8 5.1e-09 36.5 0.7 3.4 3 1 0 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 EGD99614.1 - 5.7e-12 44.5 6.3 6.9e-07 28.7 0.1 5.6 6 0 0 6 6 6 2 EF-hand domain EF-hand_1 PF00036.32 EGD99614.1 - 1.4e-10 39.9 11.0 8.4e-07 28.1 0.1 5.6 6 0 0 6 6 6 3 EF hand EF-hand_8 PF13833.6 EGD99614.1 - 3.4e-07 30.0 1.0 0.47 10.3 0.0 5.0 5 0 0 5 5 5 2 EF-hand domain pair EF-hand_5 PF13202.6 EGD99614.1 - 2.6e-06 26.6 2.5 5.7e-05 22.4 0.1 3.4 4 0 0 4 4 4 1 EF hand EF-hand_9 PF14658.6 EGD99614.1 - 0.091 13.1 0.0 23 5.4 0.0 3.5 3 0 0 3 3 3 0 EF-hand domain FeoC PF09012.10 EGD99615.1 - 0.071 13.2 0.2 1 9.5 0.0 2.4 2 0 0 2 2 2 0 FeoC like transcriptional regulator Pyr_redox_2 PF07992.14 EGD99616.1 - 4.6e-12 45.8 0.0 9.7e-11 41.4 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.19 EGD99616.1 - 5.4e-12 44.9 0.1 1.2e-10 40.5 0.0 2.5 3 0 0 3 3 3 1 Flavin-binding monooxygenase-like NAD_binding_8 PF13450.6 EGD99616.1 - 1.6e-11 44.3 0.1 3.6e-07 30.3 0.0 3.0 2 1 1 3 3 3 2 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 EGD99616.1 - 1.8e-08 34.0 0.0 3.1e-08 33.2 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EGD99616.1 - 9.5e-06 25.0 0.0 4.7e-05 22.7 0.0 2.0 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 EGD99616.1 - 0.00042 20.3 0.1 3.7 7.5 0.0 4.0 4 0 0 4 4 4 1 FAD-NAD(P)-binding Pyr_redox PF00070.27 EGD99616.1 - 0.0013 19.3 0.1 0.85 10.2 0.0 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EGD99616.1 - 0.0045 16.6 0.1 0.088 12.4 0.0 2.6 2 1 1 3 3 3 1 FAD dependent oxidoreductase Shikimate_DH PF01488.20 EGD99616.1 - 0.018 15.1 0.0 0.16 12.0 0.0 2.3 3 0 0 3 3 3 0 Shikimate / quinate 5-dehydrogenase FAD_binding_2 PF00890.24 EGD99616.1 - 0.022 13.9 0.0 0.36 9.8 0.0 2.2 2 0 0 2 2 2 0 FAD binding domain Lycopene_cycl PF05834.12 EGD99616.1 - 0.077 12.0 0.0 21 4.0 0.0 2.9 3 0 0 3 3 3 0 Lycopene cyclase protein Thi4 PF01946.17 EGD99616.1 - 0.089 12.0 0.2 0.53 9.5 0.0 2.0 2 0 0 2 2 2 0 Thi4 family Glyco_transf_25 PF01755.17 EGD99617.1 - 1.1e-05 25.4 0.0 4.5e-05 23.4 0.0 1.9 2 1 0 2 2 2 1 Glycosyltransferase family 25 (LPS biosynthesis protein) Peptidase_M22 PF00814.25 EGD99620.1 - 1.5e-45 156.0 0.0 7.3e-41 140.7 0.0 3.4 2 1 0 2 2 2 2 Glycoprotease family EPL1 PF10513.9 EGD99623.1 - 2.4e-32 112.5 0.7 4.8e-31 108.3 0.0 2.5 2 0 0 2 2 2 1 Enhancer of polycomb-like zf-HC5HC2H_2 PF13832.6 EGD99623.1 - 8e-32 109.7 3.3 8e-32 109.7 3.3 2.3 2 0 0 2 2 2 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 EGD99623.1 - 6.5e-28 96.8 1.1 6.5e-28 96.8 1.1 2.8 3 0 0 3 3 3 1 PHD-like zinc-binding domain PHD_2 PF13831.6 EGD99623.1 - 5.4e-14 51.5 2.9 5.4e-14 51.5 2.9 2.6 2 0 0 2 2 2 1 PHD-finger PHD PF00628.29 EGD99623.1 - 1.1e-08 34.8 9.8 1.1e-08 34.8 9.8 2.7 2 0 0 2 2 2 1 PHD-finger Bromodomain PF00439.25 EGD99623.1 - 0.0035 17.4 0.0 0.0076 16.3 0.0 1.5 1 0 0 1 1 1 1 Bromodomain zf-PHD-like PF15446.6 EGD99623.1 - 7.8 6.1 13.6 0.016 14.8 2.1 2.2 2 0 0 2 2 2 0 PHD/FYVE-zinc-finger like domain RRM_1 PF00076.22 EGD99624.1 - 3.1e-19 68.6 0.0 4.8e-19 67.9 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EGD99624.1 - 0.00067 19.2 0.0 0.001 18.6 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Dpy-30 PF05186.13 EGD99625.1 - 2.3e-14 52.8 0.0 3.3e-14 52.3 0.0 1.2 1 0 0 1 1 1 1 Dpy-30 motif VRR_NUC PF08774.11 EGD99626.1 - 1.9e-24 85.8 0.0 6.1e-24 84.2 0.0 1.9 1 0 0 1 1 1 1 VRR-NUC domain Ribosomal_S13_N PF08069.12 EGD99627.1 - 3e-30 104.0 0.2 3.7e-30 103.8 0.2 1.1 1 0 0 1 1 1 1 Ribosomal S13/S15 N-terminal domain PAX PF00292.18 EGD99627.1 - 0.0086 16.0 0.0 0.011 15.6 0.0 1.2 1 0 0 1 1 1 1 'Paired box' domain Chromate_transp PF02417.15 EGD99628.1 - 6.1e-58 195.4 34.7 2e-31 109.3 14.0 2.4 3 0 0 3 3 3 2 Chromate transporter NDUF_B12 PF08122.12 EGD99628.1 - 0.1 12.6 1.4 52 4.0 0.1 4.7 5 0 0 5 5 5 0 NADH-ubiquinone oxidoreductase B12 subunit family 7tm_2 PF00002.24 EGD99631.1 - 0.00064 19.1 12.3 0.0013 18.1 11.3 1.7 1 1 1 2 2 2 1 7 transmembrane receptor (Secretin family) RRM_1 PF00076.22 EGD99632.1 - 7.9e-31 105.7 0.1 2.9e-13 49.4 0.0 4.1 3 1 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EGD99632.1 - 1e-06 28.5 0.0 0.095 12.6 0.0 3.4 3 0 0 3 3 3 3 Occluded RNA-recognition motif OGG_N PF07934.12 EGD99633.1 - 2.6e-17 63.0 0.1 5.2e-17 62.1 0.1 1.5 1 0 0 1 1 1 1 8-oxoguanine DNA glycosylase, N-terminal domain HhH-GPD PF00730.25 EGD99633.1 - 9.2e-16 58.2 0.0 1.6e-15 57.5 0.0 1.4 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 EGD99633.1 - 0.00038 20.2 0.0 0.00087 19.0 0.0 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix motif FMO-like PF00743.19 EGD99634.1 - 1.1e-11 43.9 1.7 1.6e-10 40.1 0.8 2.6 2 1 0 2 2 2 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 EGD99634.1 - 7.7e-11 41.8 1.4 1.5e-06 27.7 0.8 3.2 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EGD99634.1 - 1.7e-10 40.6 0.0 1.1e-05 24.8 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EGD99634.1 - 7.5e-09 35.2 0.9 3.5e-05 23.1 0.0 3.6 4 0 0 4 4 4 1 L-lysine 6-monooxygenase (NADPH-requiring) DAO PF01266.24 EGD99634.1 - 8.1e-09 35.5 0.1 0.0052 16.4 0.0 2.8 2 1 0 3 3 3 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EGD99634.1 - 3.1e-08 33.7 0.3 1e-07 32.1 0.0 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 EGD99634.1 - 4.7e-05 22.7 0.0 0.003 16.8 0.0 2.7 3 0 0 3 3 3 1 Thi4 family NAD_binding_9 PF13454.6 EGD99634.1 - 0.00018 21.5 0.0 0.51 10.3 0.0 2.6 2 0 0 2 2 2 2 FAD-NAD(P)-binding GIDA PF01134.22 EGD99634.1 - 0.0032 16.6 0.2 0.16 11.0 0.0 2.4 2 0 0 2 2 2 1 Glucose inhibited division protein A Mqo PF06039.15 EGD99634.1 - 0.034 12.7 0.0 2.9 6.3 0.0 2.2 2 0 0 2 2 2 0 Malate:quinone oxidoreductase (Mqo) HI0933_like PF03486.14 EGD99634.1 - 0.048 12.4 0.2 8.1 5.0 0.1 3.0 3 0 0 3 3 3 0 HI0933-like protein APH PF01636.23 EGD99635.1 - 6.3e-08 32.8 1.9 1.1e-07 32.1 0.5 1.9 2 0 0 2 2 2 1 Phosphotransferase enzyme family Fungal_trans_2 PF11951.8 EGD99636.1 - 1.7e-08 33.7 0.4 3e-08 32.9 0.4 1.4 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EGD99636.1 - 2.6e-08 33.8 11.7 4.8e-08 33.0 11.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Rax2 PF12768.7 EGD99637.1 - 2.8e-68 229.6 0.0 1.3e-67 227.4 0.0 2.2 2 0 0 2 2 2 1 Cortical protein marker for cell polarity SSrecog PF03531.14 EGD99638.1 - 2.1e-30 104.4 0.2 3.9e-29 100.4 0.0 3.1 4 0 0 4 4 4 1 Structure-specific recognition protein (SSRP1) Rtt106 PF08512.12 EGD99638.1 - 1.1e-25 89.9 0.1 5.1e-25 87.7 0.0 2.1 2 0 0 2 2 2 1 Histone chaperone Rttp106-like POB3_N PF17292.2 EGD99638.1 - 4.9e-20 71.7 0.2 1.2e-18 67.3 0.0 2.6 3 0 0 3 3 3 1 POB3-like N-terminal PH domain SAP PF02037.27 EGD99639.1 - 3.7e-12 45.7 0.6 6.5e-12 44.9 0.1 1.7 2 0 0 2 2 2 1 SAP domain Tho1_MOS11_C PF18592.1 EGD99639.1 - 1.2e-06 28.2 0.1 1.2e-06 28.2 0.1 2.1 2 0 0 2 2 2 1 Tho1/MOS11 C-terminal domain CCT_2 PF09425.10 EGD99639.1 - 0.1 12.5 6.5 0.84 9.6 1.3 2.8 2 0 0 2 2 2 0 Divergent CCT motif FXMRP1_C_core PF12235.8 EGD99639.1 - 2.3 8.9 15.4 0.45 11.2 6.8 2.5 2 0 0 2 2 2 0 Fragile X-related 1 protein core C terminal Methyltransf_11 PF08241.12 EGD99641.1 - 6e-05 23.6 0.0 0.00012 22.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EGD99641.1 - 0.0052 17.5 0.0 0.011 16.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain NNMT_PNMT_TEMT PF01234.17 EGD99641.1 - 0.036 13.3 0.0 0.058 12.6 0.0 1.2 1 0 0 1 1 1 0 NNMT/PNMT/TEMT family DUF3455 PF11937.8 EGD99642.1 - 2.5e-19 70.2 0.0 3.7e-19 69.7 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3455) SF3b1 PF08920.10 EGD99643.1 - 5.1e-33 114.1 13.8 7e-33 113.6 8.0 3.0 1 1 1 2 2 2 1 Splicing factor 3B subunit 1 HEAT_2 PF13646.6 EGD99643.1 - 2e-11 44.1 8.4 0.21 12.0 0.1 8.0 6 2 3 9 9 9 3 HEAT repeats HEAT_EZ PF13513.6 EGD99643.1 - 8e-11 42.2 2.9 0.011 16.3 0.0 6.7 7 1 1 8 8 7 2 HEAT-like repeat HEAT PF02985.22 EGD99643.1 - 5.2e-09 35.6 7.9 0.69 10.3 0.2 9.0 10 0 0 10 10 8 1 HEAT repeat Cnd1 PF12717.7 EGD99643.1 - 1.4e-05 25.2 1.1 4.9 7.2 0.0 6.2 5 2 2 7 7 7 1 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 EGD99643.1 - 4.1e-05 24.1 0.2 2.3 8.9 0.0 5.4 6 0 0 6 6 6 1 Vacuolar 14 Fab1-binding region DUF3385 PF11865.8 EGD99643.1 - 0.00018 21.4 1.1 0.056 13.3 0.0 4.8 6 1 0 6 6 6 1 Domain of unknown function (DUF3385) NUC173 PF08161.12 EGD99643.1 - 0.00019 21.2 0.2 1.2 8.8 0.0 4.1 5 1 0 5 5 5 2 NUC173 domain UNC45-central PF11701.8 EGD99643.1 - 0.00094 19.2 0.0 0.0035 17.3 0.0 1.9 2 0 0 2 2 2 1 Myosin-binding striated muscle assembly central UME PF08064.13 EGD99643.1 - 0.0043 16.9 0.4 8.6 6.3 0.0 4.8 7 0 0 7 7 7 1 UME (NUC010) domain CLASP_N PF12348.8 EGD99643.1 - 0.005 16.4 0.1 0.93 9.0 0.0 3.3 3 0 0 3 3 3 1 CLASP N terminal TAF6_C PF07571.13 EGD99643.1 - 0.02 15.2 0.0 0.95 9.8 0.0 3.5 3 1 0 3 3 2 0 TAF6 C-terminal HEAT repeat domain DRIM PF07539.12 EGD99643.1 - 0.086 11.1 0.2 6.7 4.9 0.0 3.6 2 1 1 3 3 3 0 Down-regulated in metastasis CRM1_C PF08767.11 EGD99643.1 - 0.12 11.5 0.2 0.45 9.6 0.0 2.1 2 0 0 2 2 2 0 CRM1 C terminal Ecm29 PF13001.7 EGD99643.1 - 0.17 10.5 0.0 1.7 7.2 0.0 2.3 2 1 1 3 3 3 0 Proteasome stabiliser Sec1 PF00995.23 EGD99644.1 - 2.4e-120 403.5 0.0 2.7e-120 403.3 0.0 1.0 1 0 0 1 1 1 1 Sec1 family Transposase_22 PF02994.14 EGD99644.1 - 0.015 15.5 0.3 0.18 12.0 0.0 2.6 3 0 0 3 3 3 0 L1 transposable element RBD-like domain Nrap_D5 PF17406.2 EGD99645.1 - 0.83 9.4 2.6 8.2 6.2 0.2 2.4 2 1 0 2 2 2 0 Nrap protein PAP/OAS1-like domain 5 V-SNARE_C PF12352.8 EGD99645.1 - 1.3 9.3 7.1 0.092 13.0 0.8 2.3 3 0 0 3 3 3 0 Snare region anchored in the vesicle membrane C-terminus zf-C2H2 PF00096.26 EGD99646.1 - 5.9e-10 39.0 11.4 1.5e-05 25.2 4.4 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EGD99646.1 - 4.1e-07 30.3 10.3 0.00063 20.4 2.9 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EGD99646.1 - 5.7e-07 29.7 24.1 2.6e-05 24.4 0.4 3.8 4 0 0 4 4 3 3 Zinc-finger double domain zf-met PF12874.7 EGD99646.1 - 9.7e-06 25.8 4.4 1.9e-05 24.9 1.2 2.6 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 EGD99646.1 - 7.8e-05 22.6 8.7 0.00014 21.7 2.1 2.6 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EGD99646.1 - 0.00026 21.2 6.5 0.00071 19.8 2.0 3.2 3 0 0 3 3 3 1 Zinc-finger double-stranded RNA-binding zf-C2HC_2 PF13913.6 EGD99646.1 - 0.03 14.2 4.3 3.2 7.8 0.4 2.4 2 0 0 2 2 2 0 zinc-finger of a C2HC-type DarA_C PF18789.1 EGD99646.1 - 0.098 13.0 1.4 9.4 6.6 0.0 2.8 2 0 0 2 2 2 0 Defence against restriction A C-terminal Hydin_ADK PF17213.3 EGD99646.1 - 0.23 11.7 5.2 11 6.2 4.8 2.3 2 0 0 2 2 2 0 Hydin Adenylate kinase-like domain Actin_micro PF17003.5 EGD99646.1 - 0.23 10.6 0.2 0.36 10.0 0.2 1.2 1 0 0 1 1 1 0 Putative actin-like family PAT1 PF09770.9 EGD99646.1 - 0.27 9.4 12.6 0.36 9.0 12.6 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 zf-C2H2_11 PF16622.5 EGD99646.1 - 0.9 9.4 7.3 7.8 6.4 0.8 2.5 2 0 0 2 2 2 0 zinc-finger C2H2-type zf-BED PF02892.15 EGD99646.1 - 0.97 9.5 4.5 0.43 10.6 0.6 2.1 2 0 0 2 2 2 0 BED zinc finger Spt20 PF12090.8 EGD99646.1 - 1.6 8.3 18.9 2.7 7.6 18.9 1.3 1 0 0 1 1 1 0 Spt20 family Presenilin PF01080.17 EGD99646.1 - 1.8 7.2 4.7 2.6 6.7 4.7 1.1 1 0 0 1 1 1 0 Presenilin Neur_chan_memb PF02932.16 EGD99646.1 - 2.9 7.9 4.6 2.4 8.2 1.4 2.0 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Suf PF05843.14 EGD99646.1 - 4.4 7.2 8.5 2.1 8.3 5.8 1.8 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) FAD_binding_2 PF00890.24 EGD99651.1 - 2.4e-45 155.4 0.1 1.9e-44 152.4 0.1 1.9 1 1 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.7 EGD99651.1 - 8.9e-09 35.2 0.2 2e-08 34.1 0.1 1.7 2 0 0 2 2 2 1 FAD dependent oxidoreductase DAO PF01266.24 EGD99651.1 - 1.3e-07 31.6 5.9 1.5e-07 31.3 0.6 2.9 2 1 0 2 2 2 1 FAD dependent oxidoreductase HI0933_like PF03486.14 EGD99651.1 - 1.8e-06 26.9 1.8 0.00097 17.9 0.1 3.2 3 0 0 3 3 3 1 HI0933-like protein Pyr_redox_2 PF07992.14 EGD99651.1 - 5.3e-06 25.9 0.1 0.00083 18.7 0.0 2.5 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 EGD99651.1 - 0.00087 18.6 0.0 0.0015 17.8 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_3 PF13738.6 EGD99651.1 - 0.0023 17.2 0.1 0.052 12.8 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EGD99651.1 - 0.003 17.7 0.2 0.012 15.9 0.2 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain GIDA PF01134.22 EGD99651.1 - 0.0035 16.5 0.3 0.0035 16.5 0.3 2.6 3 0 0 3 3 3 1 Glucose inhibited division protein A Thi4 PF01946.17 EGD99651.1 - 0.0061 15.8 0.1 0.011 14.9 0.1 1.4 1 0 0 1 1 1 1 Thi4 family Lycopene_cycl PF05834.12 EGD99651.1 - 0.086 11.9 0.0 0.15 11.0 0.0 1.4 1 0 0 1 1 1 0 Lycopene cyclase protein AlaDh_PNT_C PF01262.21 EGD99651.1 - 0.16 11.3 0.1 0.25 10.6 0.1 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Fungal_trans PF04082.18 EGD99652.1 - 1e-22 80.5 0.1 1.7e-22 79.8 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EGD99652.1 - 3.3e-08 33.5 11.6 6.5e-08 32.6 11.6 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Telomere_reg-2 PF10193.9 EGD99653.1 - 6.4e-28 97.4 0.0 5.3e-27 94.4 0.0 2.5 2 0 0 2 2 2 1 Telomere length regulation protein ThiF PF00899.21 EGD99654.1 - 2.6e-63 213.6 0.0 5.7e-63 212.5 0.0 1.4 1 1 1 2 2 2 1 ThiF family E2_bind PF08825.10 EGD99654.1 - 8.4e-30 102.8 0.4 1.4e-29 102.1 0.4 1.4 1 0 0 1 1 1 1 E2 binding domain E1_UFD PF09358.10 EGD99654.1 - 0.0061 17.2 0.0 0.018 15.8 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin fold domain Ecm33 PF12454.8 EGD99654.1 - 0.033 14.3 2.0 0.069 13.3 2.0 1.5 1 0 0 1 1 1 0 GPI-anchored cell wall organization protein SNCAIP_SNCA_bd PF16700.5 EGD99654.1 - 0.13 12.0 0.1 0.3 10.8 0.1 1.5 1 0 0 1 1 1 0 Synphilin-1 alpha-Synuclein-binding domain UBA_e1_thiolCys PF10585.9 EGD99654.1 - 0.35 10.8 3.6 5.7 6.8 0.1 2.6 2 1 0 2 2 2 0 Ubiquitin-activating enzyme active site Rad50_zn_hook PF04423.14 EGD99654.1 - 4.5 7.2 5.4 13 5.8 0.4 2.5 2 0 0 2 2 2 0 Rad50 zinc hook motif RNA_pol_A_bac PF01000.26 EGD99655.1 - 3.1e-27 95.2 0.0 5.6e-27 94.3 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 EGD99655.1 - 5.9e-19 67.3 0.0 8.1e-19 66.8 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Complex1_49kDa PF00346.19 EGD99656.1 - 4.2e-123 409.8 0.0 6e-123 409.2 0.0 1.2 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 49 Kd subunit NiFeSe_Hases PF00374.19 EGD99656.1 - 0.046 12.6 0.0 0.077 11.9 0.0 1.3 1 1 0 1 1 1 0 Nickel-dependent hydrogenase UQ_con PF00179.26 EGD99657.1 - 5.8e-25 87.6 0.0 6.6e-25 87.4 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EGD99657.1 - 7.4e-05 22.5 0.0 0.00011 21.9 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 EGD99657.1 - 0.017 15.4 0.0 0.021 15.1 0.0 1.3 1 0 0 1 1 1 0 RWD domain MKT1_C PF12246.8 EGD99658.1 - 8.3e-82 274.0 0.0 1.3e-81 273.4 0.0 1.2 1 0 0 1 1 1 1 Temperature dependent protein affecting M2 dsRNA replication MKT1_N PF12247.8 EGD99658.1 - 2.6e-31 107.8 0.0 6.2e-31 106.6 0.0 1.7 1 0 0 1 1 1 1 Temperature dependent protein affecting M2 dsRNA replication XPG_I PF00867.18 EGD99658.1 - 1.6e-05 25.1 0.0 3.8e-05 24.0 0.0 1.6 1 0 0 1 1 1 1 XPG I-region GIT_SHD PF08518.11 EGD99658.1 - 0.028 14.0 0.2 0.059 13.0 0.2 1.5 1 0 0 1 1 1 0 Spa2 homology domain (SHD) of GIT DIOX_N PF14226.6 EGD99659.1 - 6.1e-17 62.5 0.0 7.3e-17 62.2 0.0 1.0 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal zf-MYND PF01753.18 EGD99660.1 - 7.2e-09 35.6 19.4 1.6e-08 34.5 19.4 1.7 1 0 0 1 1 1 1 MYND finger SPX PF03105.19 EGD99660.1 - 0.007 16.3 9.4 0.0073 16.3 9.4 1.1 1 0 0 1 1 1 1 SPX domain TFIIA PF03153.13 EGD99660.1 - 0.012 15.7 8.7 0.012 15.6 8.7 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Apt1 PF10351.9 EGD99660.1 - 0.062 12.1 4.7 0.072 11.9 4.7 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain FAM220 PF15487.6 EGD99660.1 - 0.21 11.2 5.8 0.27 10.8 5.8 1.3 1 0 0 1 1 1 0 FAM220 family Presenilin PF01080.17 EGD99660.1 - 0.3 9.8 4.2 0.38 9.5 4.2 1.3 1 0 0 1 1 1 0 Presenilin Ndc1_Nup PF09531.10 EGD99660.1 - 0.3 9.7 7.2 0.36 9.5 7.2 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Macoilin PF09726.9 EGD99660.1 - 0.66 8.5 6.0 0.68 8.4 6.0 1.1 1 0 0 1 1 1 0 Macoilin family SOG2 PF10428.9 EGD99660.1 - 0.71 9.0 18.1 0.88 8.7 18.1 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein Menin PF05053.13 EGD99660.1 - 1.4 7.2 7.0 1.7 6.9 7.0 1.1 1 0 0 1 1 1 0 Menin zf-TAZ PF02135.16 EGD99660.1 - 2 8.9 13.7 3.7 8.1 13.7 1.5 1 0 0 1 1 1 0 TAZ zinc finger Ribosomal_60s PF00428.19 EGD99660.1 - 2.3 8.9 7.0 4.5 7.9 2.2 2.2 2 0 0 2 2 2 0 60s Acidic ribosomal protein SR-25 PF10500.9 EGD99660.1 - 5.8 6.5 16.2 12 5.4 16.2 1.5 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein HLH PF00010.26 EGD99662.1 - 1.6e-11 43.9 0.0 6.5e-11 42.0 0.0 2.0 1 1 0 1 1 1 1 Helix-loop-helix DNA-binding domain Mito_carr PF00153.27 EGD99663.1 - 1.5e-65 217.2 0.9 4.6e-24 84.2 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Pept_tRNA_hydro PF01195.19 EGD99663.1 - 0.037 14.0 0.0 1.6 8.7 0.0 2.1 2 0 0 2 2 2 0 Peptidyl-tRNA hydrolase Dna2 PF08696.11 EGD99664.1 - 1.2e-66 224.4 0.1 3.3e-66 223.0 0.0 1.8 2 0 0 2 2 1 1 DNA replication factor Dna2 AAA_12 PF13087.6 EGD99664.1 - 2.3e-53 180.8 0.0 4.4e-53 179.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 EGD99664.1 - 1.6e-33 116.6 0.1 2.3e-17 63.6 0.0 2.6 1 1 1 2 2 2 2 AAA domain AAA_30 PF13604.6 EGD99664.1 - 3.1e-14 53.1 0.0 5.7e-14 52.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EGD99664.1 - 4e-11 43.4 0.1 9.5e-11 42.2 0.1 1.7 1 0 0 1 1 1 1 AAA domain Cas_Cas4 PF01930.17 EGD99664.1 - 6.2e-09 36.2 0.0 8.9e-07 29.1 0.0 2.5 2 0 0 2 2 2 1 Domain of unknown function DUF83 PDDEXK_1 PF12705.7 EGD99664.1 - 2e-08 34.5 0.0 1.8e-07 31.4 0.0 2.2 2 0 0 2 2 2 1 PD-(D/E)XK nuclease superfamily Viral_helicase1 PF01443.18 EGD99664.1 - 6.7e-07 29.3 0.5 0.21 11.3 0.0 4.0 4 0 0 4 4 3 2 Viral (Superfamily 1) RNA helicase Helicase_RecD PF05127.14 EGD99664.1 - 8.6e-05 22.5 0.0 0.0002 21.3 0.0 1.6 1 0 0 1 1 1 1 Helicase UvrD-helicase PF00580.21 EGD99664.1 - 0.00066 19.3 0.8 0.0014 18.2 0.1 1.9 2 0 0 2 2 2 1 UvrD/REP helicase N-terminal domain SRP54 PF00448.22 EGD99664.1 - 0.0011 18.7 0.1 0.0022 17.6 0.1 1.5 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain AAA_16 PF13191.6 EGD99664.1 - 0.0039 17.6 0.0 0.011 16.1 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain Csa1 PF06023.12 EGD99664.1 - 0.0071 15.7 0.0 0.16 11.3 0.0 2.3 2 0 0 2 2 2 1 CRISPR-associated exonuclease Csa1 PIF1 PF05970.14 EGD99664.1 - 0.017 14.3 0.2 0.056 12.6 0.2 1.8 1 1 0 1 1 1 0 PIF1-like helicase DUF2075 PF09848.9 EGD99664.1 - 0.022 14.0 0.0 0.04 13.2 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) ResIII PF04851.15 EGD99664.1 - 0.03 14.3 0.0 0.11 12.5 0.1 1.9 2 0 0 2 2 1 0 Type III restriction enzyme, res subunit DUF87 PF01935.17 EGD99664.1 - 0.053 13.6 0.1 0.14 12.2 0.1 1.7 1 0 0 1 1 1 0 Helicase HerA, central domain MobB PF03205.14 EGD99664.1 - 0.054 13.4 0.0 0.12 12.3 0.0 1.5 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B CbiA PF01656.23 EGD99664.1 - 0.062 13.4 0.5 0.15 12.1 0.5 1.6 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA PF00004.29 EGD99664.1 - 0.062 13.7 0.1 0.22 11.9 0.0 2.0 2 0 0 2 2 1 0 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 EGD99664.1 - 0.063 12.8 0.1 0.13 11.7 0.1 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region NTPase_1 PF03266.15 EGD99664.1 - 0.083 12.8 0.3 0.18 11.7 0.3 1.5 1 0 0 1 1 1 0 NTPase FtsK_SpoIIIE PF01580.18 EGD99664.1 - 0.12 11.8 0.1 0.24 10.7 0.1 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family cobW PF02492.19 EGD99664.1 - 0.13 11.9 0.0 0.67 9.5 0.0 2.0 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain MeaB PF03308.16 EGD99664.1 - 0.18 10.7 0.1 0.38 9.7 0.1 1.4 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB DUF1179 PF06678.11 EGD99664.1 - 8 6.5 7.8 7.3 6.6 0.7 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1179) Ribonuc_P_40 PF08584.11 EGD99665.1 - 1.4e-73 247.7 0.0 2.1e-73 247.1 0.0 1.2 1 0 0 1 1 1 1 Ribonuclease P 40kDa (Rpp40) subunit WD40 PF00400.32 EGD99666.1 - 1.1e-28 98.8 13.0 3.7e-07 30.7 0.0 6.8 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EGD99666.1 - 2.1e-16 60.0 0.0 0.0053 17.0 0.0 5.6 1 1 4 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Cytochrom_D1 PF02239.16 EGD99666.1 - 5.1e-08 31.8 0.0 0.0014 17.3 0.0 2.1 2 0 0 2 2 2 2 Cytochrome D1 heme domain eIF2A PF08662.11 EGD99666.1 - 0.00021 21.2 0.0 0.13 12.1 0.0 2.6 2 1 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 EGD99666.1 - 0.044 12.7 0.0 5.1 5.9 0.0 3.1 2 1 0 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein DPPIV_N PF00930.21 EGD99666.1 - 0.074 11.8 0.0 0.31 9.7 0.0 1.9 2 0 0 2 2 2 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region PD40 PF07676.12 EGD99666.1 - 0.1 12.6 4.1 4.5 7.3 0.0 4.0 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat Nup160 PF11715.8 EGD99666.1 - 0.22 10.1 0.2 9.2 4.8 0.0 2.1 1 1 1 2 2 2 0 Nucleoporin Nup120/160 VID27 PF08553.10 EGD99666.1 - 0.27 10.3 0.1 4.5 6.2 0.1 2.0 2 0 0 2 2 2 0 VID27 C-terminal WD40-like domain Fungal_trans PF04082.18 EGD99667.1 - 1.6e-17 63.4 0.1 3.2e-17 62.5 0.1 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EGD99667.1 - 8.4e-10 38.6 9.6 1.9e-09 37.5 9.6 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MCCD1 PF15707.5 EGD99667.1 - 0.16 12.4 0.4 4.6 7.8 0.0 2.7 2 0 0 2 2 2 0 Mitochondrial coiled-coil domain protein 1 Ribosomal_L2_C PF03947.18 EGD99668.1 - 1.9e-48 163.8 2.5 1e-34 119.5 1.5 2.7 2 0 0 2 2 2 2 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 EGD99668.1 - 2.6e-24 85.0 0.6 9.4e-24 83.2 0.5 2.0 2 0 0 2 2 2 1 Ribosomal Proteins L2, RNA binding domain Cyclin_N PF00134.23 EGD99669.1 - 1.1e-46 157.7 0.1 6.6e-45 151.9 0.1 2.3 2 0 0 2 2 2 2 Cyclin, N-terminal domain Cyclin_C PF02984.19 EGD99669.1 - 2.6e-32 111.4 0.1 4.9e-32 110.5 0.1 1.5 1 0 0 1 1 1 1 Cyclin, C-terminal domain HIT PF01230.23 EGD99670.1 - 3.1e-16 59.9 0.0 1e-15 58.2 0.0 1.8 2 0 0 2 2 2 1 HIT domain DcpS_C PF11969.8 EGD99670.1 - 1.3e-05 25.7 0.0 3e-05 24.5 0.0 1.5 1 1 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding CwfJ_C_1 PF04677.15 EGD99670.1 - 0.15 11.9 2.7 0.4 10.6 0.0 2.3 3 0 0 3 3 3 0 Protein similar to CwfJ C-terminus 1 UPF0020 PF01170.18 EGD99671.1 - 2e-09 37.4 0.0 1.3e-08 34.8 0.0 2.1 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 N6_Mtase PF02384.16 EGD99671.1 - 0.00083 18.7 0.0 0.0016 17.8 0.0 1.4 1 1 0 1 1 1 1 N-6 DNA Methylase MethyltransfD12 PF02086.15 EGD99671.1 - 0.094 12.4 0.0 0.35 10.5 0.0 1.8 2 0 0 2 2 2 0 D12 class N6 adenine-specific DNA methyltransferase DUF2985 PF11204.8 EGD99673.1 - 2.3e-21 75.7 3.5 5.1e-21 74.6 3.5 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2985) LTXXQ PF07813.12 EGD99673.1 - 0.0014 19.3 0.3 0.0014 19.3 0.3 2.6 2 0 0 2 2 2 1 LTXXQ motif family protein SID-1_RNA_chan PF13965.6 EGD99673.1 - 0.02 13.4 1.4 0.034 12.6 1.4 1.3 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Peptidase_S49_N PF08496.10 EGD99673.1 - 8 6.5 9.4 12 5.9 6.9 2.1 2 0 0 2 2 2 0 Peptidase family S49 N-terminal Pkinase PF00069.25 EGD99674.1 - 1.5e-05 24.5 0.0 3e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.14 EGD99674.1 - 4.1e-05 23.0 0.0 0.00011 21.7 0.0 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EGD99674.1 - 0.00019 21.4 3.6 0.00024 21.1 0.0 2.6 2 1 1 3 3 3 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EGD99674.1 - 0.077 12.6 0.0 0.18 11.3 0.0 1.5 1 0 0 1 1 1 0 Choline/ethanolamine kinase DUF4315 PF14193.6 EGD99674.1 - 1.3 9.0 7.5 3.6 7.7 7.5 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4315) SIR2 PF02146.17 EGD99675.1 - 2.8e-59 200.0 0.0 4e-59 199.5 0.0 1.2 1 0 0 1 1 1 1 Sir2 family DUF592 PF04574.13 EGD99675.1 - 1.3e-05 25.0 0.0 2.3e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF592) TPP_enzyme_M PF00205.22 EGD99675.1 - 0.0007 19.3 0.2 1.3 8.7 0.1 2.4 2 0 0 2 2 2 2 Thiamine pyrophosphate enzyme, central domain TPR_2 PF07719.17 EGD99676.1 - 1.5e-11 43.5 0.0 0.0001 22.1 0.0 5.0 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 EGD99676.1 - 6.2e-11 42.6 0.7 2.5e-05 24.7 0.0 3.7 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.6 EGD99676.1 - 6.2e-10 39.2 0.0 8.6e-06 26.0 0.0 3.6 4 1 0 4 4 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 EGD99676.1 - 7.4e-10 38.8 2.4 0.13 13.2 0.0 5.5 4 2 1 5 5 5 2 Tetratricopeptide repeat TPR_8 PF13181.6 EGD99676.1 - 9.6e-10 37.9 0.0 1.4e-05 24.9 0.0 4.8 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_1 PF00515.28 EGD99676.1 - 5.5e-09 35.5 0.0 0.00031 20.4 0.0 4.0 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 EGD99676.1 - 4.7e-06 27.2 0.0 0.039 14.6 0.0 3.5 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.6 EGD99676.1 - 8.2e-05 22.2 0.0 0.00078 19.1 0.0 2.5 2 0 0 2 2 2 1 TPR repeat TPR_9 PF13371.6 EGD99676.1 - 0.00014 22.0 1.0 0.26 11.4 0.0 3.8 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 EGD99676.1 - 0.00031 20.6 0.0 0.081 13.0 0.0 4.0 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_10 PF13374.6 EGD99676.1 - 0.00066 19.5 0.1 11 6.0 0.0 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_MalT PF17874.1 EGD99676.1 - 0.0052 16.2 0.0 0.24 10.7 0.0 2.4 2 0 0 2 2 2 1 MalT-like TPR region ANAPC3 PF12895.7 EGD99676.1 - 0.026 14.8 0.0 17 5.7 0.0 3.1 3 0 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 SHNi-TPR PF10516.9 EGD99676.1 - 0.035 13.6 0.3 5.6 6.5 0.1 2.8 2 0 0 2 2 2 0 SHNi-TPR TPR_21 PF09976.9 EGD99676.1 - 0.037 13.7 0.0 1.1 8.9 0.0 2.6 2 1 1 3 3 3 0 Tetratricopeptide repeat-like domain C_GCAxxG_C_C PF09719.10 EGD99676.1 - 0.12 12.6 0.0 0.28 11.5 0.0 1.6 1 0 0 1 1 1 0 Putative redox-active protein (C_GCAxxG_C_C) TPR_4 PF07721.14 EGD99676.1 - 0.4 11.4 1.8 5.9 7.8 0.0 3.4 4 0 0 4 4 2 0 Tetratricopeptide repeat RWD PF05773.22 EGD99677.1 - 2.7e-24 85.7 1.8 2.7e-24 85.7 1.8 1.6 2 0 0 2 2 2 1 RWD domain DFRP_C PF16543.5 EGD99677.1 - 7.3e-05 23.2 15.5 0.00032 21.1 15.4 2.2 1 1 0 1 1 1 1 DRG Family Regulatory Proteins, Tma46 DUF1682 PF07946.14 EGD99677.1 - 0.00091 18.5 6.2 0.0012 18.1 6.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1682) DUF1485 PF07364.12 EGD99677.1 - 0.038 13.3 0.1 0.24 10.6 0.0 1.9 1 1 1 2 2 2 0 Metallopeptidase family M81 UQ_con PF00179.26 EGD99677.1 - 0.13 11.9 0.1 0.48 10.1 0.0 2.0 2 0 0 2 2 2 0 Ubiquitin-conjugating enzyme MPM1 PF17234.2 EGD99677.1 - 3.4 7.9 10.0 1.5 9.0 7.6 1.5 1 1 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 Putative_PNPOx PF01243.20 EGD99678.1 - 3.5e-06 27.1 0.0 6.2e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase GST_C PF00043.25 EGD99679.1 - 2.7e-16 59.6 0.1 5.9e-16 58.5 0.1 1.6 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EGD99679.1 - 8.9e-14 51.6 0.0 2.6e-13 50.1 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EGD99679.1 - 2.4e-11 43.7 0.0 4.5e-11 42.9 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 EGD99679.1 - 2e-10 40.9 0.0 3.5e-10 40.2 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EGD99679.1 - 1.4e-08 34.8 0.0 2.6e-08 33.9 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EGD99679.1 - 4.7e-08 32.9 0.2 1.4e-07 31.4 0.1 1.9 2 1 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_5 PF16865.5 EGD99679.1 - 0.0067 17.0 0.0 0.012 16.2 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Complex1_LYR PF05347.15 EGD99680.1 - 7.9e-10 38.6 0.1 2.9e-09 36.8 0.1 2.0 1 0 0 1 1 1 1 Complex 1 protein (LYR family) DUF1154 PF06631.11 EGD99680.1 - 0.49 10.5 5.2 0.64 10.1 3.9 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1154) UQ_con PF00179.26 EGD99681.1 - 7.3e-18 64.6 0.0 7.9e-18 64.5 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme DCB PF16213.5 EGD99682.1 - 9.8e-44 149.1 4.7 9.8e-44 149.1 4.7 3.6 4 0 0 4 4 4 1 Dimerisation and cyclophilin-binding domain of Mon2 Sec7_N PF12783.7 EGD99682.1 - 3.1e-39 134.4 5.0 3.1e-39 134.4 5.0 4.8 4 1 0 4 4 4 1 Guanine nucleotide exchange factor in Golgi transport N-terminal Mon2_C PF16206.5 EGD99682.1 - 6.6e-20 70.9 1.9 6.6e-20 70.9 1.9 2.6 3 0 0 3 3 3 1 C-terminal region of Mon2 protein DUF1981 PF09324.10 EGD99682.1 - 0.00021 21.1 0.9 0.059 13.2 0.0 5.2 5 0 0 5 5 5 1 Domain of unknown function (DUF1981) Gly_acyl_tr_N PF06021.11 EGD99682.1 - 0.0033 17.6 0.5 0.089 12.9 0.0 2.7 2 0 0 2 2 2 1 Aralkyl acyl-CoA:amino acid N-acyltransferase Antimicrobial19 PF08225.11 EGD99682.1 - 0.26 11.0 1.2 0.56 9.9 0.0 2.3 2 0 0 2 2 2 0 Pseudin antimicrobial peptide Vps26 PF03643.15 EGD99683.1 - 1.2e-128 427.9 0.1 1.4e-128 427.7 0.1 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 Arrestin_N PF00339.29 EGD99683.1 - 0.00057 20.0 0.1 2.1 8.4 0.0 3.3 4 0 0 4 4 4 2 Arrestin (or S-antigen), N-terminal domain AAA_18 PF13238.6 EGD99684.1 - 8e-11 42.6 0.0 5.3e-10 39.9 0.0 2.0 1 1 0 1 1 1 1 AAA domain SKI PF01202.22 EGD99684.1 - 1.4e-10 41.5 0.1 1.8e-09 37.9 0.1 2.1 1 1 0 1 1 1 1 Shikimate kinase AAA_33 PF13671.6 EGD99684.1 - 2.9e-10 40.5 0.0 8.7e-10 38.9 0.0 1.8 1 1 0 1 1 1 1 AAA domain Rad17 PF03215.15 EGD99684.1 - 1.1e-06 28.7 0.0 2.2e-06 27.7 0.0 1.4 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_17 PF13207.6 EGD99684.1 - 1.2e-05 25.8 0.0 0.0051 17.3 0.0 2.3 2 0 0 2 2 2 1 AAA domain dNK PF01712.19 EGD99684.1 - 1.4e-05 25.0 0.0 0.17 11.7 0.0 2.2 2 0 0 2 2 2 2 Deoxynucleoside kinase AAA PF00004.29 EGD99684.1 - 8.5e-05 23.0 0.0 0.00015 22.2 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 EGD99684.1 - 0.00038 20.5 0.0 0.00096 19.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain Cytidylate_kin PF02224.18 EGD99684.1 - 0.00042 20.1 0.0 0.0014 18.4 0.0 1.8 2 0 0 2 2 2 1 Cytidylate kinase AAA_16 PF13191.6 EGD99684.1 - 0.00049 20.5 0.0 0.00076 19.9 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain NACHT PF05729.12 EGD99684.1 - 0.00056 19.9 0.0 0.0013 18.7 0.0 1.5 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 EGD99684.1 - 0.00066 20.0 0.1 0.00097 19.4 0.1 1.7 1 1 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 EGD99684.1 - 0.0018 18.6 0.0 0.0038 17.6 0.0 1.5 1 0 0 1 1 1 1 RNA helicase AAA_28 PF13521.6 EGD99684.1 - 0.0041 17.4 0.0 0.0078 16.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain Cytidylate_kin2 PF13189.6 EGD99684.1 - 0.0054 16.9 0.0 0.052 13.7 0.0 2.1 2 0 0 2 2 2 1 Cytidylate kinase-like family T2SSE PF00437.20 EGD99684.1 - 0.0059 15.7 0.0 0.012 14.7 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein APS_kinase PF01583.20 EGD99684.1 - 0.0064 16.4 0.0 0.024 14.5 0.0 1.8 1 1 0 1 1 1 1 Adenylylsulphate kinase PRK PF00485.18 EGD99684.1 - 0.0081 15.9 0.0 0.015 15.0 0.0 1.4 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family TsaE PF02367.17 EGD99684.1 - 0.01 15.8 0.0 0.018 15.0 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Zeta_toxin PF06414.12 EGD99684.1 - 0.011 15.0 0.1 0.044 13.1 0.0 1.8 2 0 0 2 2 2 0 Zeta toxin ATPase_2 PF01637.18 EGD99684.1 - 0.012 15.5 0.0 0.025 14.5 0.0 1.5 2 0 0 2 2 1 0 ATPase domain predominantly from Archaea AAA_30 PF13604.6 EGD99684.1 - 0.014 15.1 0.0 0.026 14.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 EGD99684.1 - 0.017 15.6 0.0 0.033 14.7 0.0 1.5 1 0 0 1 1 1 0 ABC transporter PhoH PF02562.16 EGD99684.1 - 0.022 14.2 0.0 0.037 13.5 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein tRNA_lig_kinase PF08303.11 EGD99684.1 - 0.023 14.8 0.0 0.056 13.5 0.0 1.6 2 0 0 2 2 1 0 tRNA ligase kinase domain AAA_11 PF13086.6 EGD99684.1 - 0.027 14.3 0.1 0.058 13.2 0.0 1.4 1 1 0 1 1 1 0 AAA domain Viral_helicase1 PF01443.18 EGD99684.1 - 0.038 13.7 0.0 0.073 12.8 0.0 1.5 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase NTPase_1 PF03266.15 EGD99684.1 - 0.044 13.7 0.0 0.15 12.0 0.0 1.8 2 0 0 2 2 2 0 NTPase DUF2075 PF09848.9 EGD99684.1 - 0.049 12.9 0.0 0.075 12.3 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_5 PF07728.14 EGD99684.1 - 0.056 13.5 0.0 0.098 12.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 EGD99684.1 - 0.057 13.2 0.0 0.096 12.4 0.0 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain Mg_chelatase PF01078.21 EGD99684.1 - 0.062 12.7 0.0 0.12 11.7 0.0 1.5 1 1 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_7 PF12775.7 EGD99684.1 - 0.066 12.7 0.0 0.2 11.1 0.0 1.8 2 0 0 2 2 2 0 P-loop containing dynein motor region Herpes_Helicase PF02689.14 EGD99684.1 - 0.072 11.0 0.0 0.095 10.6 0.0 1.1 1 0 0 1 1 1 0 Helicase AAA_19 PF13245.6 EGD99684.1 - 0.074 13.4 0.1 0.17 12.3 0.1 1.5 2 0 0 2 2 1 0 AAA domain NB-ARC PF00931.22 EGD99684.1 - 0.11 11.7 0.0 0.21 10.8 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain CoaE PF01121.20 EGD99684.1 - 0.11 12.1 0.0 0.24 11.1 0.0 1.5 1 0 0 1 1 1 0 Dephospho-CoA kinase AAA_25 PF13481.6 EGD99684.1 - 0.15 11.6 0.0 0.28 10.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain ADK PF00406.22 EGD99684.1 - 0.15 12.1 0.1 2.2 8.3 0.0 2.1 2 0 0 2 2 2 0 Adenylate kinase PduV-EutP PF10662.9 EGD99684.1 - 0.18 11.6 0.0 0.54 10.0 0.0 1.7 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Acetyltransf_3 PF13302.7 EGD99685.1 - 1e-13 52.1 0.0 1.3e-13 51.9 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Peptidase_C14 PF00656.22 EGD99686.1 - 9e-63 212.5 0.0 1.2e-62 212.1 0.0 1.1 1 0 0 1 1 1 1 Caspase domain 2-oxoacid_dh PF00198.23 EGD99687.1 - 7.4e-81 271.0 0.6 9.9e-81 270.6 0.6 1.2 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) E3_binding PF02817.17 EGD99687.1 - 8.9e-14 51.5 0.0 2.3e-13 50.2 0.0 1.8 1 0 0 1 1 1 1 e3 binding domain Biotin_lipoyl PF00364.22 EGD99687.1 - 2.5e-12 46.4 0.0 6.9e-12 45.0 0.0 1.8 1 0 0 1 1 1 1 Biotin-requiring enzyme Phage_spike PF18715.1 EGD99687.1 - 2.8 8.1 6.8 0.47 10.6 1.3 2.3 2 0 0 2 2 2 0 Phage spike trimer PI-PLC-X PF00388.19 EGD99688.1 - 1.2e-10 41.2 0.0 1.9e-10 40.5 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain DUF1598 PF07643.11 EGD99689.1 - 0.079 13.2 0.1 0.17 12.2 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1598) Ribosomal_L10 PF00466.20 EGD99689.1 - 0.088 12.9 0.0 0.18 12.0 0.0 1.5 1 0 0 1 1 1 0 Ribosomal protein L10 F-box PF00646.33 EGD99690.1 - 0.1 12.5 0.5 0.4 10.6 0.2 2.0 2 0 0 2 2 2 0 F-box domain Glycos_transf_3 PF00591.21 EGD99691.1 - 3.6e-55 187.3 0.0 3.8e-46 157.8 0.1 2.2 1 1 1 2 2 2 2 Glycosyl transferase family, a/b domain Glycos_trans_3N PF02885.17 EGD99691.1 - 6e-06 26.0 1.2 8.3e-06 25.6 0.3 1.7 2 0 0 2 2 2 1 Glycosyl transferase family, helical bundle domain DNA_RNApol_7kD PF03604.13 EGD99692.1 - 2.2e-17 62.4 7.0 2.9e-17 62.0 7.0 1.2 1 0 0 1 1 1 1 DNA directed RNA polymerase, 7 kDa subunit HypA PF01155.19 EGD99692.1 - 0.00072 19.5 0.3 0.00076 19.5 0.3 1.1 1 0 0 1 1 1 1 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DUF2318 PF10080.9 EGD99692.1 - 0.0024 17.9 0.2 0.0026 17.8 0.2 1.1 1 0 0 1 1 1 1 Predicted membrane protein (DUF2318) DUF2197 PF09963.9 EGD99692.1 - 0.0047 17.2 2.8 0.22 11.8 0.2 2.2 1 1 1 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2197) zinc-ribbon_6 PF10005.9 EGD99692.1 - 0.0055 17.4 0.5 0.0073 17.0 0.5 1.2 1 0 0 1 1 1 1 zinc-ribbon domain DZR PF12773.7 EGD99692.1 - 0.012 15.6 0.3 0.017 15.1 0.3 1.3 1 0 0 1 1 1 0 Double zinc ribbon Zn-ribbon_8 PF09723.10 EGD99692.1 - 0.015 15.4 0.7 0.027 14.6 0.7 1.4 1 0 0 1 1 1 0 Zinc ribbon domain GFA PF04828.14 EGD99692.1 - 0.016 15.6 1.0 2.5 8.5 0.1 2.1 1 1 1 2 2 2 0 Glutathione-dependent formaldehyde-activating enzyme DUF1451 PF07295.11 EGD99692.1 - 0.019 15.0 0.3 0.021 14.8 0.3 1.1 1 0 0 1 1 1 0 Zinc-ribbon containing domain zinc-ribbons_6 PF07191.12 EGD99692.1 - 0.019 14.9 0.4 0.027 14.5 0.4 1.3 1 0 0 1 1 1 0 zinc-ribbons zf_UBZ PF18439.1 EGD99692.1 - 0.021 14.4 1.6 1.4 8.6 0.2 2.2 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger DUF2757 PF10955.8 EGD99692.1 - 0.037 14.3 0.6 0.046 14.0 0.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2757) Zn_ribbon_SprT PF17283.2 EGD99692.1 - 0.063 13.2 2.7 0.11 12.5 2.7 1.4 1 0 0 1 1 1 0 SprT-like zinc ribbon domain Zn_ribbon_recom PF13408.6 EGD99692.1 - 0.12 12.9 5.4 2.1 8.9 0.9 2.2 1 1 1 2 2 2 0 Recombinase zinc beta ribbon domain DUF951 PF06107.11 EGD99692.1 - 0.31 11.0 3.3 0.97 9.4 0.4 2.1 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF951) TFIIS_C PF01096.18 EGD99692.1 - 0.91 9.4 4.9 7.5 6.5 0.7 2.5 1 1 0 2 2 2 0 Transcription factor S-II (TFIIS) fn3 PF00041.21 EGD99693.1 - 1.9e-11 44.1 4.4 2.3e-06 27.8 0.0 4.2 4 1 0 4 4 4 2 Fibronectin type III domain Lipase_GDSL_2 PF13472.6 EGD99693.1 - 5.3e-11 43.2 0.0 1.5e-08 35.3 0.0 2.4 2 0 0 2 2 2 2 GDSL-like Lipase/Acylhydrolase family Fe_hyd_lg_C PF02906.14 EGD99696.1 - 1.7e-50 172.0 0.0 3.3e-50 171.0 0.0 1.5 1 1 0 1 1 1 1 Iron only hydrogenase large subunit, C-terminal domain DUF2263 PF10021.9 EGD99697.1 - 3.2e-19 69.8 0.0 1.5e-18 67.6 0.0 2.1 2 1 0 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2263) Fapy_DNA_glyco PF01149.24 EGD99698.1 - 3e-34 118.1 0.0 6.5e-34 117.0 0.0 1.6 1 0 0 1 1 1 1 Formamidopyrimidine-DNA glycosylase N-terminal domain H2TH PF06831.14 EGD99698.1 - 8.7e-21 73.7 0.0 1.7e-20 72.8 0.0 1.4 1 0 0 1 1 1 1 Formamidopyrimidine-DNA glycosylase H2TH domain FbpA PF05833.11 EGD99698.1 - 0.0055 15.5 0.0 0.012 14.4 0.0 1.4 2 0 0 2 2 2 1 Fibronectin-binding protein A N-terminus (FbpA) Mitofilin PF09731.9 EGD99698.1 - 0.062 12.1 6.9 0.082 11.7 6.9 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Pol_alpha_B_N PF08418.10 EGD99698.1 - 1.1 9.2 13.4 1.5 8.7 13.4 1.2 1 0 0 1 1 1 0 DNA polymerase alpha subunit B N-terminal Cid2 PF09774.9 EGD99699.1 - 1.5e-56 191.3 0.1 1.7e-56 191.1 0.1 1.1 1 0 0 1 1 1 1 Caffeine-induced death protein 2 NARP1 PF12569.8 EGD99700.1 - 1.1e-215 717.5 7.9 1.5e-214 713.7 3.6 2.3 2 0 0 2 2 2 2 NMDA receptor-regulated protein 1 TPR_14 PF13428.6 EGD99700.1 - 1.9e-23 81.1 12.3 0.0013 19.4 1.6 10.7 8 2 3 11 11 11 4 Tetratricopeptide repeat TPR_2 PF07719.17 EGD99700.1 - 4.6e-21 73.2 35.1 9.8e-05 22.2 0.5 10.9 11 0 0 11 11 11 7 Tetratricopeptide repeat TPR_19 PF14559.6 EGD99700.1 - 2.2e-19 69.7 23.6 6.3e-05 23.4 0.0 7.4 8 0 0 8 8 6 5 Tetratricopeptide repeat TPR_16 PF13432.6 EGD99700.1 - 4.1e-17 62.5 12.1 0.0026 18.3 1.7 7.9 8 1 1 9 9 9 4 Tetratricopeptide repeat TPR_1 PF00515.28 EGD99700.1 - 5.3e-13 48.2 33.6 1.5e-05 24.6 0.6 9.9 10 0 0 10 10 10 5 Tetratricopeptide repeat TPR_12 PF13424.6 EGD99700.1 - 1.7e-12 47.4 12.7 0.057 13.7 0.3 7.1 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_9 PF13371.6 EGD99700.1 - 1.1e-11 44.6 12.1 0.0017 18.5 0.0 7.1 6 2 1 7 7 7 2 Tetratricopeptide repeat TPR_8 PF13181.6 EGD99700.1 - 2.1e-10 40.0 28.3 0.00032 20.7 0.3 8.6 10 0 0 10 10 8 3 Tetratricopeptide repeat TPR_11 PF13414.6 EGD99700.1 - 6.2e-10 38.6 15.9 0.0004 20.0 1.4 6.6 7 0 0 7 7 7 2 TPR repeat ANAPC3 PF12895.7 EGD99700.1 - 1.9e-09 37.6 15.4 0.00025 21.2 3.4 5.2 4 1 1 5 5 5 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.6 EGD99700.1 - 1.2e-08 34.8 16.1 0.051 14.0 0.0 7.7 9 0 0 9 9 8 3 Tetratricopeptide repeat TPR_21 PF09976.9 EGD99700.1 - 1.5e-07 31.3 8.2 7.5e-05 22.5 0.1 3.9 2 1 1 3 3 3 2 Tetratricopeptide repeat-like domain TPR_15 PF13429.6 EGD99700.1 - 3.2e-07 29.9 13.0 0.0035 16.6 1.0 4.0 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_6 PF13174.6 EGD99700.1 - 1.4e-05 25.4 20.8 0.16 12.7 0.2 8.2 9 0 0 9 9 8 2 Tetratricopeptide repeat TPR_7 PF13176.6 EGD99700.1 - 3.6e-05 23.5 14.1 1 9.6 0.4 6.9 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_MalT PF17874.1 EGD99700.1 - 0.0001 21.8 5.5 1.7 7.9 0.9 4.0 2 1 2 4 4 4 3 MalT-like TPR region BTAD PF03704.17 EGD99700.1 - 0.00036 21.0 2.4 0.0036 17.7 0.2 3.2 2 0 0 2 2 2 1 Bacterial transcriptional activator domain TPR_3 PF07720.12 EGD99700.1 - 0.0011 18.9 7.7 0.06 13.4 0.2 3.8 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_4 PF07721.14 EGD99700.1 - 0.0087 16.6 8.0 3.9 8.4 2.1 4.4 4 0 0 4 4 3 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EGD99700.1 - 0.013 15.5 13.6 13 6.0 0.1 6.4 6 0 0 6 6 6 0 Fis1 C-terminal tetratricopeptide repeat Rapsyn_N PF10579.9 EGD99700.1 - 0.023 14.8 0.1 0.11 12.6 0.1 2.2 1 0 0 1 1 1 0 Rapsyn N-terminal myristoylation and linker region ATP-synt_Eps PF04627.13 EGD99700.1 - 0.49 10.4 0.0 0.49 10.4 0.0 2.7 3 0 0 3 3 2 0 Mitochondrial ATP synthase epsilon chain TPR_20 PF14561.6 EGD99700.1 - 0.9 9.9 6.0 9.2 6.7 0.4 4.2 4 1 1 5 5 4 0 Tetratricopeptide repeat Tim54 PF11711.8 EGD99701.1 - 5.7e-140 466.4 0.0 6.7e-140 466.1 0.0 1.0 1 0 0 1 1 1 1 Inner membrane protein import complex subunit Tim54 Pkinase PF00069.25 EGD99702.1 - 4.6e-56 190.1 0.0 7.9e-55 186.1 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD99702.1 - 1.2e-24 87.0 0.3 5.3e-19 68.5 0.1 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Haspin_kinase PF12330.8 EGD99702.1 - 4.3e-06 25.9 0.1 6.3e-06 25.4 0.1 1.2 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 EGD99702.1 - 0.00027 21.0 0.2 0.039 13.9 0.2 2.6 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.6 EGD99702.1 - 0.0007 19.0 0.2 0.0018 17.6 0.0 1.7 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 EGD99702.1 - 0.0016 17.9 0.0 0.0038 16.6 0.0 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family NFACT-C PF11923.8 EGD99702.1 - 0.032 14.1 0.4 0.067 13.1 0.4 1.5 1 0 0 1 1 1 0 NFACT protein C-terminal domain Pkinase_fungal PF17667.1 EGD99702.1 - 0.041 12.6 0.0 0.074 11.8 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase Seadorna_VP7 PF07387.11 EGD99702.1 - 0.049 12.7 0.0 0.078 12.0 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 TFIIA PF03153.13 EGD99702.1 - 0.049 13.6 14.4 0.084 12.9 14.4 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PepX_N PF09168.10 EGD99702.1 - 0.063 13.7 0.7 0.14 12.6 0.7 1.5 1 0 0 1 1 1 0 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal Pox_ser-thr_kin PF05445.11 EGD99702.1 - 0.076 12.0 0.0 0.13 11.2 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase RIO1 PF01163.22 EGD99702.1 - 0.49 10.0 2.4 0.84 9.2 0.0 2.1 2 0 0 2 2 2 0 RIO1 family SF3A2 PF16835.5 EGD99703.1 - 3.3e-37 126.8 0.0 4.8e-37 126.2 0.0 1.2 1 0 0 1 1 1 1 Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11) zf-met PF12874.7 EGD99703.1 - 1.2e-05 25.5 0.5 2.1e-05 24.8 0.5 1.4 1 0 0 1 1 1 1 Zinc-finger of C2H2 type PRP4 PF08799.11 EGD99703.1 - 0.049 13.2 1.5 0.11 12.0 1.5 1.7 1 0 0 1 1 1 0 pre-mRNA processing factor 4 (PRP4) like Methyltransf_11 PF08241.12 EGD99704.1 - 5.1e-13 49.5 0.0 1.3e-12 48.1 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EGD99704.1 - 2.6e-10 40.9 0.0 6.5e-10 39.6 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EGD99704.1 - 3.4e-08 34.1 0.0 6.2e-08 33.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EGD99704.1 - 0.00023 21.0 0.0 0.00035 20.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EGD99704.1 - 0.0039 17.0 0.0 0.0058 16.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EGD99704.1 - 0.041 13.4 0.0 0.065 12.8 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain ERG4_ERG24 PF01222.17 EGD99705.1 - 7.2e-140 466.5 20.4 8.2e-140 466.4 20.4 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family MFS_1 PF07690.16 EGD99706.1 - 2e-41 142.1 35.5 4.1e-41 141.1 32.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EGD99706.1 - 9.1e-12 44.6 12.0 9.1e-12 44.6 12.0 2.9 3 0 0 3 3 3 1 Sugar (and other) transporter MFS_1_like PF12832.7 EGD99706.1 - 0.00046 19.2 3.0 0.036 12.9 2.6 3.0 1 1 1 2 2 2 1 MFS_1 like family CAP_GLY PF01302.25 EGD99707.1 - 1.2e-20 73.2 0.1 2.1e-20 72.5 0.1 1.3 1 0 0 1 1 1 1 CAP-Gly domain LRR_4 PF12799.7 EGD99707.1 - 1.4e-13 50.8 14.5 0.00096 19.5 0.0 5.4 4 1 1 5 5 5 4 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EGD99707.1 - 7.4e-06 25.6 5.7 0.0072 15.9 0.4 3.1 2 1 1 3 3 3 2 Leucine-rich repeat LRR_8 PF13855.6 EGD99707.1 - 0.00015 21.5 25.5 0.013 15.2 2.8 5.8 4 2 3 7 7 7 5 Leucine rich repeat LRR_6 PF13516.6 EGD99707.1 - 0.00019 21.2 7.2 2 8.6 0.0 5.5 6 0 0 6 6 6 2 Leucine Rich repeat LRR_1 PF00560.33 EGD99707.1 - 0.018 15.5 10.7 39 5.4 0.0 6.7 6 1 0 6 6 6 0 Leucine Rich Repeat zf-U1 PF06220.12 EGD99708.1 - 6.7e-08 32.2 0.5 1.1e-07 31.5 0.5 1.4 1 0 0 1 1 1 1 U1 zinc finger Zn_clus PF00172.18 EGD99709.1 - 1.4e-08 34.7 10.4 2.4e-08 33.9 10.4 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain 2-Hacid_dh_C PF02826.19 EGD99710.1 - 1.3e-57 194.1 0.0 1.7e-57 193.6 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EGD99710.1 - 1.2e-12 47.6 0.0 1.4e-12 47.5 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 EGD99710.1 - 4.7e-05 23.6 0.0 7.1e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase IlvN PF07991.12 EGD99710.1 - 0.15 11.6 0.0 0.28 10.7 0.0 1.4 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain REC104 PF17378.2 EGD99710.1 - 0.21 11.4 0.0 0.31 10.8 0.0 1.2 1 0 0 1 1 1 0 Meiotic recombination protein REC104 CwfJ_C_1 PF04677.15 EGD99711.1 - 6.2e-29 100.3 0.0 1.2e-28 99.4 0.0 1.5 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 CwfJ_C_2 PF04676.14 EGD99711.1 - 7.5e-29 100.5 0.1 7.5e-29 100.5 0.1 2.3 2 0 0 2 2 2 1 Protein similar to CwfJ C-terminus 2 FumaraseC_C PF10415.9 EGD99711.1 - 0.028 14.8 1.2 2.2 8.8 0.1 3.0 3 0 0 3 3 3 0 Fumarase C C-terminus ATP_bind_1 PF03029.17 EGD99712.1 - 1.3e-70 237.9 0.0 1.9e-70 237.4 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein GTP_EFTU PF00009.27 EGD99712.1 - 0.00016 21.2 0.0 0.01 15.4 0.0 2.8 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain MeaB PF03308.16 EGD99712.1 - 0.00063 18.8 0.0 0.12 11.4 0.0 2.3 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB MMR_HSR1 PF01926.23 EGD99712.1 - 0.00083 19.4 0.0 0.02 15.0 0.0 2.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_24 PF13479.6 EGD99712.1 - 0.0011 18.7 0.0 0.0025 17.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain SRP54 PF00448.22 EGD99712.1 - 0.0012 18.5 0.0 0.031 13.9 0.0 2.3 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain PRK PF00485.18 EGD99712.1 - 0.0037 17.0 0.0 0.0096 15.7 0.0 1.6 2 0 0 2 2 2 1 Phosphoribulokinase / Uridine kinase family Roc PF08477.13 EGD99712.1 - 0.0046 17.2 0.0 0.93 9.7 0.0 2.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase NACHT PF05729.12 EGD99712.1 - 0.0056 16.6 0.0 0.012 15.5 0.0 1.5 1 0 0 1 1 1 1 NACHT domain FeoB_N PF02421.18 EGD99712.1 - 0.0061 16.1 0.0 0.13 11.8 0.0 2.3 2 0 0 2 2 2 1 Ferrous iron transport protein B cobW PF02492.19 EGD99712.1 - 0.01 15.4 0.0 1.6 8.3 0.0 2.4 2 1 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain NB-ARC PF00931.22 EGD99712.1 - 0.011 15.0 0.0 0.022 14.0 0.0 1.5 1 0 0 1 1 1 0 NB-ARC domain G-alpha PF00503.20 EGD99712.1 - 0.013 14.7 0.0 0.47 9.5 0.0 2.6 3 0 0 3 3 3 0 G-protein alpha subunit AAA_16 PF13191.6 EGD99712.1 - 0.015 15.7 0.0 0.044 14.2 0.0 1.8 2 0 0 2 2 2 0 AAA ATPase domain AAA_33 PF13671.6 EGD99712.1 - 0.019 15.1 0.0 0.041 14.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 EGD99712.1 - 0.024 14.4 0.0 0.046 13.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain CLP1_P PF16575.5 EGD99712.1 - 0.024 14.4 0.0 0.12 12.1 0.0 1.9 2 0 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_22 PF13401.6 EGD99712.1 - 0.027 14.8 0.0 0.074 13.3 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 EGD99712.1 - 0.027 15.0 0.0 1.3 9.5 0.0 2.2 2 0 0 2 2 2 0 AAA domain Arf PF00025.21 EGD99712.1 - 0.028 13.9 0.0 2.7 7.4 0.0 2.8 3 0 0 3 3 3 0 ADP-ribosylation factor family RsgA_GTPase PF03193.16 EGD99712.1 - 0.029 14.3 0.0 5.8 6.8 0.0 3.0 3 0 0 3 3 3 0 RsgA GTPase AAA_7 PF12775.7 EGD99712.1 - 0.033 13.7 0.0 0.067 12.7 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region DUF872 PF05915.12 EGD99713.1 - 0.11 12.7 0.7 2.5 8.3 0.2 2.3 2 1 0 2 2 2 0 Eukaryotic protein of unknown function (DUF872) GST_N_3 PF13417.6 EGD99714.1 - 7.7e-20 71.1 0.0 1.7e-19 70.0 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EGD99714.1 - 6.3e-16 58.4 0.0 1.9e-15 56.9 0.0 1.9 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 EGD99714.1 - 1.7e-07 31.4 0.0 3.6e-07 30.4 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EGD99714.1 - 1.7e-06 27.9 0.1 3.6e-06 26.9 0.1 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_5 PF16865.5 EGD99714.1 - 0.022 15.3 0.0 0.056 14.0 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EGD99714.1 - 0.03 14.5 0.0 0.14 12.3 0.0 2.2 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain Glutaredoxin PF00462.24 EGD99714.1 - 0.08 13.2 0.0 0.15 12.3 0.0 1.5 1 0 0 1 1 1 0 Glutaredoxin TERB2 PF15101.6 EGD99714.1 - 0.15 12.1 9.1 0.19 11.8 2.6 2.5 3 0 0 3 3 3 0 Telomere-associated protein TERB2 Spt20 PF12090.8 EGD99714.1 - 3.3 7.3 22.4 0.12 11.9 15.0 2.2 2 0 0 2 2 2 0 Spt20 family Inhibitor_I9 PF05922.16 EGD99714.1 - 4.5 8.0 8.4 1.3 9.8 1.0 2.5 2 0 0 2 2 2 0 Peptidase inhibitor I9 SUZ PF12752.7 EGD99715.1 - 9e-06 26.4 5.5 9e-06 26.4 5.5 4.0 3 2 0 3 3 3 1 SUZ domain GRP PF07172.11 EGD99715.1 - 7.7 7.3 12.7 4.1 8.2 9.1 2.1 2 0 0 2 2 2 0 Glycine rich protein family Barttin PF15462.6 EGD99716.1 - 1.3 8.7 4.8 0.37 10.5 0.5 1.9 1 1 1 2 2 2 0 Bartter syndrome, infantile, with sensorineural deafness (Barttin) Serglycin PF04360.12 EGD99717.1 - 0.28 11.1 3.2 0.3 11.0 0.7 2.2 2 0 0 2 2 2 0 Serglycin F-box-like PF12937.7 EGD99718.1 - 5.5e-05 23.0 0.2 0.00015 21.6 0.2 1.8 1 0 0 1 1 1 1 F-box-like LRR_6 PF13516.6 EGD99718.1 - 0.00029 20.6 12.0 4.2 7.7 0.0 6.1 6 0 0 6 6 6 2 Leucine Rich repeat LRR_4 PF12799.7 EGD99718.1 - 0.00064 20.1 14.7 0.058 13.8 0.2 5.7 5 0 0 5 5 5 1 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EGD99718.1 - 0.012 16.1 9.3 52 5.0 0.3 6.9 6 0 0 6 6 6 0 Leucine Rich Repeat F-box PF00646.33 EGD99718.1 - 0.048 13.6 1.7 0.3 11.0 1.7 2.4 1 1 0 1 1 1 0 F-box domain LRR19-TM PF15176.6 EGD99719.1 - 1.8 8.6 3.5 4.3 7.4 0.0 3.1 3 0 0 3 3 3 0 Leucine-rich repeat family 19 TM domain AA_permease_2 PF13520.6 EGD99721.1 - 8.4e-56 189.6 51.3 9.9e-56 189.4 51.3 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EGD99721.1 - 1.1e-23 83.7 44.9 1.4e-23 83.2 44.9 1.0 1 0 0 1 1 1 1 Amino acid permease DUF962 PF06127.11 EGD99721.1 - 0.29 11.3 7.6 2.4 8.3 0.0 3.9 3 3 0 3 3 3 0 Protein of unknown function (DUF962) p450 PF00067.22 EGD99722.1 - 6.8e-50 170.1 0.0 4.8e-49 167.3 0.0 2.1 1 1 0 1 1 1 1 Cytochrome P450 DUF3965 PF13112.6 EGD99722.1 - 0.1 11.8 0.3 9.3 5.4 0.0 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF3965) APH PF01636.23 EGD99723.1 - 3.4e-13 50.1 0.0 4.6e-13 49.6 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EGD99723.1 - 9.1e-12 45.0 0.0 3.2e-10 40.0 0.0 2.2 1 1 0 1 1 1 1 Choline/ethanolamine kinase LPD11 PF18824.1 EGD99723.1 - 0.065 13.3 0.0 0.52 10.4 0.0 2.3 2 0 0 2 2 2 0 Large polyvalent protein-associated domain 11 Pkinase PF00069.25 EGD99723.1 - 0.11 11.9 0.0 7.7 5.8 0.0 2.2 2 0 0 2 2 2 0 Protein kinase domain PH_TFIIH PF08567.11 EGD99725.1 - 4.6e-24 84.5 0.0 1.1e-23 83.3 0.0 1.7 1 0 0 1 1 1 1 TFIIH p62 subunit, N-terminal domain BSD PF03909.17 EGD99725.1 - 5.7e-24 83.9 8.0 1.2e-11 44.4 1.0 3.0 3 0 0 3 3 3 2 BSD domain TetR PF13972.6 EGD99725.1 - 0.081 12.6 0.0 0.25 11.0 0.0 1.9 2 0 0 2 2 2 0 Bacterial transcriptional repressor Anillin_N PF16018.5 EGD99725.1 - 0.091 13.4 0.6 7.7 7.2 0.1 2.9 2 0 0 2 2 2 0 Anillin N-terminus PIN_8 PF18476.1 EGD99725.1 - 1.6 8.5 6.6 0.13 12.1 0.2 2.4 3 0 0 3 3 3 0 PIN like domain DUF1751 PF08551.10 EGD99726.1 - 0.0022 18.6 1.3 0.0041 17.7 0.6 1.9 1 1 0 1 1 1 1 Eukaryotic integral membrane protein (DUF1751) ING PF12998.7 EGD99727.1 - 4.9e-09 36.7 0.0 1.1e-08 35.6 0.0 1.6 1 0 0 1 1 1 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.29 EGD99727.1 - 2.5e-06 27.3 6.9 4.1e-06 26.6 6.9 1.3 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 EGD99727.1 - 0.049 13.2 2.6 0.083 12.5 2.6 1.4 1 0 0 1 1 1 0 PHD-finger zf-HC5HC2H PF13771.6 EGD99727.1 - 0.19 12.0 2.0 0.39 11.0 2.0 1.5 1 0 0 1 1 1 0 PHD-like zinc-binding domain DUF4504 PF14953.6 EGD99727.1 - 0.19 11.1 0.0 0.29 10.5 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4504) Transket_pyr PF02779.24 EGD99728.1 - 1.6e-66 223.4 0.0 2.7e-66 222.6 0.0 1.4 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain OxoGdeHyase_C PF16870.5 EGD99728.1 - 1.7e-56 190.1 0.0 2.9e-56 189.4 0.0 1.4 1 0 0 1 1 1 1 2-oxoglutarate dehydrogenase C-terminal E1_dh PF00676.20 EGD99728.1 - 2.9e-56 190.6 0.0 4.3e-56 190.1 0.0 1.2 1 0 0 1 1 1 1 Dehydrogenase E1 component 2-oxogl_dehyd_N PF16078.5 EGD99728.1 - 2.9e-20 71.5 0.6 2.9e-20 71.5 0.6 1.8 2 0 0 2 2 2 1 2-oxoglutarate dehydrogenase N-terminus MCU PF04678.13 EGD99729.1 - 0.19 11.8 0.1 0.2 11.7 0.1 1.1 1 0 0 1 1 1 0 Mitochondrial calcium uniporter SHR-BD PF06650.12 EGD99730.1 - 9.5e-93 310.5 0.0 4.1e-91 305.1 0.0 3.1 3 1 0 3 3 3 1 SHR-binding domain of vacuolar-sorting associated protein 13 VPS13_mid_rpt PF16910.5 EGD99730.1 - 1.1e-92 309.8 11.3 6.4e-87 290.9 0.3 5.5 5 0 0 5 5 5 2 Repeating coiled region of VPS13 VPS13_C PF16909.5 EGD99730.1 - 2e-74 249.2 3.8 4.4e-70 235.1 0.3 2.8 2 0 0 2 2 2 2 Vacuolar-sorting-associated 13 protein C-terminal VPS13 PF16908.5 EGD99730.1 - 1.9e-66 224.3 5.0 2.6e-65 220.5 0.0 4.3 5 0 0 5 5 5 1 Vacuolar sorting-associated protein 13, N-terminal Chorein_N PF12624.7 EGD99730.1 - 1.2e-40 138.2 0.0 3.6e-40 136.7 0.0 1.9 1 0 0 1 1 1 1 N-terminal region of Chorein or VPS13 ATG_C PF09333.11 EGD99730.1 - 7.3e-06 26.3 0.2 4e-05 23.9 0.0 2.3 2 0 0 2 2 2 1 Autophagy-related protein C terminal domain DUF3429 PF11911.8 EGD99732.1 - 9.2e-44 149.2 13.1 1.4e-43 148.6 13.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3429) FGGY_C PF02782.16 EGD99733.1 - 3e-71 239.3 0.6 1e-70 237.5 0.4 1.9 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.21 EGD99733.1 - 2.4e-63 214.0 0.0 3.2e-63 213.6 0.0 1.2 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain BcrAD_BadFG PF01869.20 EGD99733.1 - 0.042 13.3 0.4 0.18 11.3 0.0 1.9 2 0 0 2 2 2 0 BadF/BadG/BcrA/BcrD ATPase family Peptidase_M41 PF01434.18 EGD99734.1 - 4.5e-54 183.2 0.1 8.1e-54 182.4 0.1 1.4 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 EGD99734.1 - 3.5e-42 144.0 0.0 7.1e-42 143.0 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EGD99734.1 - 9.3e-10 38.2 0.0 2.6e-09 36.7 0.0 1.7 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 EGD99734.1 - 2.7e-05 24.2 0.0 8.1e-05 22.6 0.0 1.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) TIP49 PF06068.13 EGD99734.1 - 7e-05 22.2 0.0 0.00014 21.2 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain RuvB_N PF05496.12 EGD99734.1 - 0.0001 22.1 0.0 0.0021 17.8 0.0 2.6 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EGD99734.1 - 0.00011 22.7 3.1 0.00048 20.5 0.6 3.1 3 1 0 3 3 2 1 AAA ATPase domain AAA_22 PF13401.6 EGD99734.1 - 0.00013 22.2 0.2 0.014 15.6 0.2 2.9 1 1 0 1 1 1 1 AAA domain AAA_2 PF07724.14 EGD99734.1 - 0.0017 18.5 0.0 0.0056 16.8 0.0 1.9 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_33 PF13671.6 EGD99734.1 - 0.0055 16.9 0.0 0.019 15.1 0.0 2.0 2 0 0 2 2 1 1 AAA domain IstB_IS21 PF01695.17 EGD99734.1 - 0.0084 15.9 0.0 0.016 14.9 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_18 PF13238.6 EGD99734.1 - 0.016 15.8 0.0 0.055 14.0 0.0 1.9 2 0 0 2 2 1 0 AAA domain AAA_25 PF13481.6 EGD99734.1 - 0.018 14.6 1.7 0.75 9.3 0.2 2.4 1 1 0 2 2 2 0 AAA domain Mg_chelatase PF01078.21 EGD99734.1 - 0.021 14.2 0.3 0.045 13.1 0.3 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI DUF815 PF05673.13 EGD99734.1 - 0.03 13.5 0.0 0.057 12.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) ATPase PF06745.13 EGD99734.1 - 0.054 12.8 0.0 1.6 8.0 0.0 2.5 3 0 0 3 3 3 0 KaiC AAA_28 PF13521.6 EGD99734.1 - 0.056 13.7 0.4 0.16 12.2 0.0 2.1 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 EGD99734.1 - 0.065 13.1 0.4 2.3 8.1 0.1 2.5 2 0 0 2 2 2 0 NACHT domain TsaE PF02367.17 EGD99734.1 - 0.088 12.8 0.0 0.35 10.9 0.0 1.9 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_14 PF13173.6 EGD99734.1 - 0.11 12.6 0.0 0.44 10.6 0.0 2.1 2 0 0 2 2 1 0 AAA domain AAA_17 PF13207.6 EGD99734.1 - 0.16 12.4 0.2 0.46 10.9 0.0 1.9 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 EGD99734.1 - 0.18 11.0 0.8 0.71 9.1 0.5 2.1 1 1 1 2 2 2 0 Zeta toxin NTP_transferase PF00483.23 EGD99736.1 - 4.2e-52 177.2 0.0 7.3e-52 176.4 0.0 1.4 2 0 0 2 2 2 1 Nucleotidyl transferase Hexapep PF00132.24 EGD99736.1 - 1.6e-15 56.1 9.8 1.2e-10 40.7 3.0 4.0 2 1 1 3 3 3 3 Bacterial transferase hexapeptide (six repeats) NTP_transf_3 PF12804.7 EGD99736.1 - 2.2e-09 37.9 0.0 2.9e-09 37.5 0.0 1.2 1 0 0 1 1 1 1 MobA-like NTP transferase domain Hexapep_2 PF14602.6 EGD99736.1 - 2e-06 27.4 1.3 2e-06 27.4 1.3 3.5 3 1 0 3 3 3 1 Hexapeptide repeat of succinyl-transferase DUF4954 PF16314.5 EGD99736.1 - 0.0027 15.9 0.1 0.0069 14.6 0.1 1.6 1 1 1 2 2 2 1 Domain of unknown function (DUF4954) IspD PF01128.19 EGD99736.1 - 0.11 12.2 0.0 0.17 11.6 0.0 1.3 1 0 0 1 1 1 0 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase adh_short PF00106.25 EGD99737.1 - 1.7e-08 34.2 0.0 0.00018 21.0 0.0 3.3 2 1 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EGD99737.1 - 0.00022 20.9 0.0 0.13 11.8 0.0 2.4 2 1 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase SAGA-Tad1 PF12767.7 EGD99739.1 - 0.18 11.6 2.6 0.2 11.4 2.6 1.2 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit HNH_2 PF13391.6 EGD99740.1 - 2.7e-14 53.1 0.0 6.4e-14 51.8 0.0 1.7 1 0 0 1 1 1 1 HNH endonuclease ADIP PF11559.8 EGD99742.1 - 0.022 14.9 6.3 0.25 11.4 6.2 1.9 1 1 0 1 1 1 0 Afadin- and alpha -actinin-Binding Retrotran_gag_2 PF14223.6 EGD99742.1 - 0.029 14.1 0.5 0.045 13.4 0.5 1.3 1 1 0 1 1 1 0 gag-polypeptide of LTR copia-type Seryl_tRNA_N PF02403.22 EGD99742.1 - 0.03 14.5 1.2 0.038 14.2 1.2 1.1 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain DUF1335 PF07056.11 EGD99742.1 - 0.034 14.2 0.0 0.056 13.6 0.0 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1335) HrcA PF01628.21 EGD99742.1 - 0.036 14.0 1.5 0.038 13.9 1.5 1.1 1 0 0 1 1 1 0 HrcA protein C terminal domain Fib_alpha PF08702.10 EGD99742.1 - 0.45 10.7 3.5 0.65 10.2 3.3 1.3 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family FKBP_C PF00254.28 EGD99745.1 - 9.6e-12 45.1 0.0 1.2e-11 44.8 0.0 1.1 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase HNH_2 PF13391.6 EGD99746.1 - 3.7e-12 46.2 0.0 7.7e-12 45.2 0.0 1.6 1 0 0 1 1 1 1 HNH endonuclease Ran_BP1 PF00638.18 EGD99747.1 - 8.5e-15 55.1 0.1 1.8e-08 34.6 0.2 2.4 2 0 0 2 2 2 2 RanBP1 domain HSP70 PF00012.20 EGD99748.1 - 1.5e-11 43.2 0.0 8.4e-10 37.5 0.0 2.1 2 0 0 2 2 2 2 Hsp70 protein MreB_Mbl PF06723.13 EGD99748.1 - 0.041 12.7 0.0 0.065 12.0 0.0 1.2 1 0 0 1 1 1 0 MreB/Mbl protein ADIP PF11559.8 EGD99749.1 - 0.0069 16.5 3.0 0.017 15.2 3.0 1.6 1 0 0 1 1 1 1 Afadin- and alpha -actinin-Binding bZIP_2 PF07716.15 EGD99749.1 - 0.057 13.5 6.1 1.9 8.6 0.1 2.9 1 1 1 2 2 2 0 Basic region leucine zipper YabA PF06156.13 EGD99749.1 - 0.067 13.8 1.1 0.5 11.0 0.7 2.3 2 1 0 2 2 2 0 Initiation control protein YabA FlxA PF14282.6 EGD99749.1 - 0.92 9.5 5.0 0.22 11.5 1.1 1.9 2 0 0 2 2 2 0 FlxA-like protein TolA_bind_tri PF16331.5 EGD99749.1 - 3.7 7.7 7.5 11 6.2 6.5 2.3 2 0 0 2 2 2 0 TolA binding protein trimerisation MMR_HSR1 PF01926.23 EGD99750.1 - 5.7e-08 32.8 2.7 1.7e-07 31.3 0.0 2.5 2 1 0 2 2 2 1 50S ribosome-binding GTPase AIG1 PF04548.16 EGD99750.1 - 4.6e-07 29.4 1.0 7.6e-07 28.7 0.0 1.9 2 0 0 2 2 2 1 AIG1 family RsgA_GTPase PF03193.16 EGD99750.1 - 0.00011 22.1 0.2 0.00011 22.1 0.2 2.4 3 0 0 3 3 3 1 RsgA GTPase Septin PF00735.18 EGD99750.1 - 0.0038 16.5 0.0 0.0038 16.5 0.0 2.3 2 1 0 2 2 2 1 Septin FeoB_N PF02421.18 EGD99750.1 - 0.0067 16.0 0.0 0.016 14.7 0.0 1.6 1 0 0 1 1 1 1 Ferrous iron transport protein B NB-ARC PF00931.22 EGD99750.1 - 0.0072 15.5 0.8 0.016 14.4 0.1 1.9 2 0 0 2 2 2 1 NB-ARC domain Dynamin_N PF00350.23 EGD99750.1 - 0.018 15.1 15.3 0.045 13.8 0.0 3.9 2 2 1 3 3 2 0 Dynamin family IIGP PF05049.13 EGD99750.1 - 0.022 13.8 0.1 0.022 13.8 0.1 1.7 2 1 1 3 3 3 0 Interferon-inducible GTPase (IIGP) Viral_helicase1 PF01443.18 EGD99750.1 - 0.025 14.3 0.4 0.077 12.7 0.4 1.7 1 1 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_22 PF13401.6 EGD99750.1 - 0.041 14.1 0.1 0.041 14.1 0.1 2.4 2 2 0 2 2 2 0 AAA domain SRPRB PF09439.10 EGD99750.1 - 0.049 13.1 0.1 0.049 13.1 0.1 2.5 2 1 1 3 3 3 0 Signal recognition particle receptor beta subunit ABC_tran PF00005.27 EGD99750.1 - 0.087 13.3 0.0 0.087 13.3 0.0 2.7 2 1 0 2 2 1 0 ABC transporter AAA_29 PF13555.6 EGD99750.1 - 0.11 12.3 0.0 0.3 10.8 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF4407 PF14362.6 EGD99750.1 - 0.19 11.1 14.3 0.31 10.4 14.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Phage_lysozyme PF00959.19 EGD99750.1 - 2.9 8.4 4.7 22 5.5 0.0 3.5 2 1 0 2 2 2 0 Phage lysozyme Fzo_mitofusin PF04799.13 EGD99750.1 - 4.1 6.9 15.5 0.19 11.3 2.1 2.7 2 1 1 3 3 3 0 fzo-like conserved region Exonuc_VII_L PF02601.15 EGD99750.1 - 9 5.8 14.7 13 5.2 14.7 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Cu-oxidase_3 PF07732.15 EGD99751.1 - 2.4e-43 146.9 0.6 2.3e-42 143.8 0.9 2.3 2 0 0 2 2 2 1 Multicopper oxidase Cu-oxidase_2 PF07731.14 EGD99751.1 - 4.9e-41 139.7 2.8 2.8e-35 121.0 0.0 4.2 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase PF00394.22 EGD99751.1 - 6.3e-26 91.4 0.1 2.1e-25 89.7 0.0 1.9 3 0 0 3 3 3 1 Multicopper oxidase Yip1 PF04893.17 EGD99752.1 - 2.3e-13 50.3 15.7 4.1e-13 49.4 15.7 1.4 1 1 0 1 1 1 1 Yip1 domain DUF1282 PF06930.12 EGD99752.1 - 0.012 15.4 2.4 0.018 14.8 2.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1282) IBR PF01485.21 EGD99753.1 - 0.0058 16.8 6.7 0.0058 16.8 6.7 5.1 5 1 0 5 5 5 3 IBR domain, a half RING-finger domain DMA PF03474.14 EGD99753.1 - 0.024 14.2 0.0 0.055 13.1 0.0 1.6 1 0 0 1 1 1 0 DMRTA motif adh_short PF00106.25 EGD99754.1 - 7.5e-83 276.8 5.6 1e-42 145.8 0.4 2.3 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EGD99754.1 - 6.1e-66 222.3 3.2 5.9e-34 117.6 0.2 2.5 2 1 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase MaoC_dehydratas PF01575.19 EGD99754.1 - 8.2e-32 109.4 0.0 1.6e-31 108.4 0.0 1.4 1 0 0 1 1 1 1 MaoC like domain KR PF08659.10 EGD99754.1 - 2e-24 86.5 3.2 1.1e-11 45.0 0.3 2.6 2 1 0 2 2 2 2 KR domain THF_DHG_CYH_C PF02882.19 EGD99754.1 - 6.7e-05 22.3 0.6 0.0099 15.2 0.5 2.4 2 0 0 2 2 2 2 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain 3HCDH_N PF02737.18 EGD99754.1 - 1.2 9.0 5.4 14 5.5 0.2 2.5 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DUF543 PF04418.12 EGD99754.1 - 3.6 7.6 5.4 20 5.3 0.4 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF543) KAP_NTPase PF07693.14 EGD99755.1 - 0.026 13.7 0.0 0.027 13.7 0.0 1.2 1 0 0 1 1 1 0 KAP family P-loop domain TsaE PF02367.17 EGD99755.1 - 0.027 14.5 0.0 0.063 13.3 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE MeaB PF03308.16 EGD99755.1 - 0.033 13.2 0.1 4.5 6.2 0.0 2.2 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB LysM PF01476.20 EGD99756.1 - 0.067 13.3 0.0 0.22 11.6 0.0 1.9 2 0 0 2 2 2 0 LysM domain Fungal_trans PF04082.18 EGD99757.1 - 3.1e-36 124.8 0.0 2.6e-35 121.8 0.0 2.3 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EGD99757.1 - 0.0032 17.6 1.0 0.0064 16.6 1.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain AP3D1 PF06375.11 EGD99758.1 - 0.013 15.8 6.3 0.013 15.8 6.3 1.5 2 0 0 2 2 2 0 AP-3 complex subunit delta-1 PPDFL PF15060.6 EGD99758.1 - 0.074 13.6 0.3 0.15 12.6 0.3 1.4 1 0 0 1 1 1 0 Differentiation and proliferation regulator DUF3464 PF11947.8 EGD99758.1 - 0.15 11.9 0.7 0.21 11.3 0.7 1.4 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 Connexin PF00029.19 EGD99758.1 - 0.5 10.1 1.1 0.7 9.6 1.1 1.2 1 0 0 1 1 1 0 Connexin BRF1 PF07741.13 EGD99758.1 - 5.3 7.4 13.5 11 6.4 13.5 1.4 1 0 0 1 1 1 0 Brf1-like TBP-binding domain Hce2 PF14856.6 EGD99759.1 - 7.2e-31 106.5 1.3 1.7e-30 105.3 1.3 1.7 1 0 0 1 1 1 1 Pathogen effector; putative necrosis-inducing factor Glyco_hydro_18 PF00704.28 EGD99759.1 - 1.4e-21 77.5 0.2 9.9e-11 41.9 0.0 2.5 2 1 1 3 3 3 2 Glycosyl hydrolases family 18 Chitin_bind_1 PF00187.19 EGD99759.1 - 0.0015 18.9 7.3 0.0015 18.9 7.3 2.6 3 0 0 3 3 3 1 Chitin recognition protein LysM PF01476.20 EGD99759.1 - 0.02 14.9 3.9 0.36 10.9 0.1 3.3 3 0 0 3 3 3 0 LysM domain PigN PF04987.14 EGD99760.1 - 3.4e-163 543.7 27.9 3.4e-163 543.7 27.9 1.4 2 0 0 2 2 2 1 Phosphatidylinositolglycan class N (PIG-N) Phosphodiest PF01663.22 EGD99760.1 - 7.1e-10 39.0 4.3 3.2e-08 33.5 4.1 2.3 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 EGD99760.1 - 7.7e-09 35.4 0.0 1.2e-08 34.8 0.0 1.3 1 0 0 1 1 1 1 Sulfatase Metalloenzyme PF01676.18 EGD99760.1 - 6.1e-05 22.5 0.0 0.00012 21.6 0.0 1.4 1 0 0 1 1 1 1 Metalloenzyme superfamily LolB PF03550.14 EGD99760.1 - 0.14 12.2 0.1 0.25 11.3 0.1 1.3 1 0 0 1 1 1 0 Outer membrane lipoprotein LolB Csm1 PF12539.8 EGD99761.1 - 6.9e-32 109.9 0.2 2.3e-31 108.2 0.1 1.9 2 0 0 2 2 1 1 Chromosome segregation protein Csm1/Pcs1 Atg14 PF10186.9 EGD99761.1 - 0.00014 21.1 9.5 0.00014 21.1 9.5 1.7 2 0 0 2 2 2 1 Vacuolar sorting 38 and autophagy-related subunit 14 V_ATPase_I PF01496.19 EGD99761.1 - 0.001 17.1 7.3 0.001 17.1 7.3 1.5 2 0 0 2 2 1 1 V-type ATPase 116kDa subunit family PKcGMP_CC PF16808.5 EGD99761.1 - 0.0021 17.9 2.1 0.0021 17.9 2.1 2.3 2 0 0 2 2 1 1 Coiled-coil N-terminus of cGMP-dependent protein kinase MscS_porin PF12795.7 EGD99761.1 - 0.0022 17.6 17.7 0.0022 17.6 17.7 1.9 2 0 0 2 2 2 1 Mechanosensitive ion channel porin domain TolA_bind_tri PF16331.5 EGD99761.1 - 0.0031 17.5 9.5 0.0031 17.5 9.5 2.4 1 1 1 2 2 2 1 TolA binding protein trimerisation Filament PF00038.21 EGD99761.1 - 0.0053 16.4 11.3 0.01 15.5 11.3 1.5 1 0 0 1 1 1 1 Intermediate filament protein Spc7 PF08317.11 EGD99761.1 - 0.0058 15.6 16.5 0.011 14.7 16.5 1.3 1 0 0 1 1 1 1 Spc7 kinetochore protein EzrA PF06160.12 EGD99761.1 - 0.012 13.8 9.6 0.018 13.2 9.6 1.2 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA Allexi_40kDa PF05549.11 EGD99761.1 - 0.022 14.3 6.5 0.06 12.8 6.5 1.7 1 0 0 1 1 1 0 Allexivirus 40kDa protein Prominin PF05478.11 EGD99761.1 - 0.042 11.8 8.4 0.063 11.2 8.4 1.1 1 0 0 1 1 1 0 Prominin TPR_MLP1_2 PF07926.12 EGD99761.1 - 0.099 12.7 22.5 0.41 10.7 22.5 2.2 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein DUF4200 PF13863.6 EGD99761.1 - 0.1 13.0 14.6 0.28 11.6 14.6 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) Macoilin PF09726.9 EGD99761.1 - 0.14 10.7 21.3 0.2 10.2 21.3 1.1 1 0 0 1 1 1 0 Macoilin family CENP-O PF09496.10 EGD99761.1 - 0.14 12.1 3.7 0.38 10.7 3.7 1.7 1 0 0 1 1 1 0 Cenp-O kinetochore centromere component COG5 PF10392.9 EGD99761.1 - 0.26 11.5 8.7 0.55 10.4 8.7 1.5 1 0 0 1 1 1 0 Golgi transport complex subunit 5 TMPIT PF07851.13 EGD99761.1 - 0.32 10.2 9.5 0.54 9.5 9.5 1.3 1 0 0 1 1 1 0 TMPIT-like protein DHR10 PF18595.1 EGD99761.1 - 0.32 11.1 24.2 19 5.3 24.2 3.0 1 1 0 1 1 1 0 Designed helical repeat protein 10 domain DUF3450 PF11932.8 EGD99761.1 - 0.33 10.2 13.9 0.69 9.2 13.9 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) Erp_C PF06780.11 EGD99761.1 - 0.36 10.9 6.4 2.3 8.2 0.4 2.9 2 1 1 3 3 3 0 Erp protein C-terminus MCU PF04678.13 EGD99761.1 - 0.38 10.8 7.5 0.93 9.6 7.5 1.7 1 0 0 1 1 1 0 Mitochondrial calcium uniporter Spc42p PF11544.8 EGD99761.1 - 0.44 10.6 11.7 0.076 13.0 4.8 3.0 1 1 1 2 2 2 0 Spindle pole body component Spc42p CREPT PF16566.5 EGD99761.1 - 0.54 10.4 11.8 0.95 9.6 11.1 1.7 2 0 0 2 2 1 0 Cell-cycle alteration and expression-elevated protein in tumour Exonuc_VII_L PF02601.15 EGD99761.1 - 0.67 9.5 13.3 0.038 13.6 8.1 1.5 2 0 0 2 2 1 0 Exonuclease VII, large subunit Med9 PF07544.13 EGD99761.1 - 0.67 10.1 15.6 2.8 8.1 12.1 2.6 1 1 1 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 FliJ PF02050.16 EGD99761.1 - 0.83 9.9 16.0 1.7 8.9 16.0 1.5 1 0 0 1 1 1 0 Flagellar FliJ protein DUF2203 PF09969.9 EGD99761.1 - 1.8 9.3 9.8 0.14 12.9 4.4 2.1 2 0 0 2 2 1 0 Uncharacterized conserved protein (DUF2203) Nup88 PF10168.9 EGD99761.1 - 2 6.1 10.3 2.9 5.6 10.3 1.1 1 0 0 1 1 1 0 Nuclear pore component FUSC PF04632.12 EGD99761.1 - 2 6.8 4.1 2.9 6.3 4.1 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family HR1 PF02185.16 EGD99761.1 - 2.1 8.5 17.4 2.1 8.5 11.9 2.9 1 1 1 2 2 2 0 Hr1 repeat COG6 PF06419.11 EGD99761.1 - 2.4 6.3 13.1 3.2 5.8 13.1 1.1 1 0 0 1 1 1 0 Conserved oligomeric complex COG6 Fib_alpha PF08702.10 EGD99761.1 - 2.4 8.4 13.6 9.1 6.5 13.3 2.1 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family DUF3138 PF11336.8 EGD99761.1 - 2.5 6.6 6.0 3.9 6.0 6.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) Baculo_PEP_C PF04513.12 EGD99761.1 - 3.9 7.5 11.0 2.6 8.1 8.5 1.9 2 0 0 2 2 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF724 PF05266.14 EGD99761.1 - 3.9 7.2 12.4 9.4 6.0 12.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF724) USP8_interact PF08941.10 EGD99761.1 - 4.4 7.1 6.1 1.9 8.3 3.2 1.7 1 1 1 2 2 2 0 USP8 interacting DUF1664 PF07889.12 EGD99761.1 - 5.7 7.0 8.0 16 5.5 7.9 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) IFT57 PF10498.9 EGD99761.1 - 6 5.7 20.5 0.042 12.8 9.6 2.1 2 0 0 2 2 2 0 Intra-flagellar transport protein 57 DUF4446 PF14584.6 EGD99761.1 - 6.6 6.7 11.9 15 5.5 3.8 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF4446) CorA PF01544.18 EGD99761.1 - 7.2 5.8 8.2 4.1 6.6 6.3 1.5 2 0 0 2 2 1 0 CorA-like Mg2+ transporter protein Rootletin PF15035.6 EGD99761.1 - 7.6 6.5 20.3 0.51 10.3 15.0 1.8 2 0 0 2 2 1 0 Ciliary rootlet component, centrosome cohesion AAA PF00004.29 EGD99762.1 - 6.1e-37 127.0 0.0 1.6e-36 125.7 0.0 1.7 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EGD99762.1 - 1.6e-08 34.2 0.0 3.6e-08 33.1 0.0 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_14 PF13173.6 EGD99762.1 - 1.6e-05 25.0 0.0 9.4e-05 22.4 0.0 2.2 1 1 1 2 2 2 1 AAA domain AAA_5 PF07728.14 EGD99762.1 - 1.6e-05 25.0 0.3 0.00029 20.9 0.1 2.9 3 1 0 3 3 2 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EGD99762.1 - 2e-05 25.1 0.6 0.00014 22.3 0.1 2.6 2 1 0 2 2 1 1 AAA ATPase domain RuvB_N PF05496.12 EGD99762.1 - 2.2e-05 24.3 0.0 4.9e-05 23.1 0.0 1.7 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 EGD99762.1 - 0.00017 21.7 0.0 0.0005 20.2 0.0 1.8 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 EGD99762.1 - 0.00038 20.8 0.1 0.0062 16.8 0.0 2.5 1 1 1 2 2 2 1 AAA domain AAA_18 PF13238.6 EGD99762.1 - 0.00051 20.6 0.1 0.003 18.1 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EGD99762.1 - 0.00061 20.0 0.0 0.0013 18.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 EGD99762.1 - 0.00075 19.3 0.0 0.0014 18.4 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein Mg_chelatase PF01078.21 EGD99762.1 - 0.00097 18.6 0.1 0.002 17.5 0.1 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_25 PF13481.6 EGD99762.1 - 0.0012 18.5 0.1 0.027 14.0 0.1 2.3 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 EGD99762.1 - 0.0015 18.9 0.0 0.0049 17.2 0.0 2.1 1 1 1 2 2 1 1 RNA helicase TniB PF05621.11 EGD99762.1 - 0.0028 17.1 0.0 2.9 7.3 0.0 2.6 1 1 1 2 2 2 2 Bacterial TniB protein NACHT PF05729.12 EGD99762.1 - 0.0041 17.1 0.1 0.015 15.2 0.0 2.0 2 0 0 2 2 2 1 NACHT domain Parvo_NS1 PF01057.17 EGD99762.1 - 0.0044 16.1 0.0 0.0072 15.5 0.0 1.3 1 0 0 1 1 1 1 Parvovirus non-structural protein NS1 AAA_24 PF13479.6 EGD99762.1 - 0.0085 15.8 0.0 0.016 14.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain Sigma54_activat PF00158.26 EGD99762.1 - 0.0093 15.7 0.0 0.02 14.6 0.0 1.5 1 0 0 1 1 1 1 Sigma-54 interaction domain Sigma54_activ_2 PF14532.6 EGD99762.1 - 0.0093 16.1 0.0 0.021 14.9 0.0 1.6 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_28 PF13521.6 EGD99762.1 - 0.0098 16.1 0.0 0.02 15.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain Rad17 PF03215.15 EGD99762.1 - 0.011 15.6 0.1 0.038 13.9 0.0 1.8 1 1 1 2 2 2 0 Rad17 P-loop domain ABC_tran PF00005.27 EGD99762.1 - 0.027 15.0 0.2 0.088 13.3 0.0 2.0 2 1 0 2 2 2 0 ABC transporter DUF815 PF05673.13 EGD99762.1 - 0.043 13.0 0.0 0.087 12.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_7 PF12775.7 EGD99762.1 - 0.046 13.2 0.0 0.093 12.2 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region CPT PF07931.12 EGD99762.1 - 0.061 13.2 0.0 0.14 12.0 0.0 1.6 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein AAA_11 PF13086.6 EGD99762.1 - 0.062 13.1 1.1 0.34 10.6 0.0 2.3 2 1 0 2 2 2 0 AAA domain ATPase_2 PF01637.18 EGD99762.1 - 0.063 13.2 0.0 0.24 11.3 0.0 1.9 1 1 1 2 2 2 0 ATPase domain predominantly from Archaea AAA_6 PF12774.7 EGD99762.1 - 0.067 12.2 0.0 0.11 11.5 0.0 1.2 1 0 0 1 1 1 0 Hydrolytic ATP binding site of dynein motor region TsaE PF02367.17 EGD99762.1 - 0.071 13.1 0.0 0.13 12.2 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE TIP49 PF06068.13 EGD99762.1 - 0.081 12.1 0.0 0.36 10.0 0.0 1.9 2 0 0 2 2 2 0 TIP49 P-loop domain ATPase PF06745.13 EGD99762.1 - 0.13 11.6 0.0 0.57 9.5 0.0 1.9 1 1 1 2 2 2 0 KaiC Viral_helicase1 PF01443.18 EGD99762.1 - 0.14 11.8 0.0 0.26 11.0 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase Cys_Met_Meta_PP PF01053.20 EGD99763.1 - 3.4e-141 470.2 0.0 3.9e-141 470.0 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 EGD99763.1 - 0.00026 20.4 0.0 0.00077 18.9 0.0 1.7 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Beta_elim_lyase PF01212.21 EGD99763.1 - 0.014 14.7 0.0 0.046 13.0 0.0 1.7 2 0 0 2 2 2 0 Beta-eliminating lyase MFS_1 PF07690.16 EGD99764.1 - 1.2e-37 129.7 37.0 1.4e-25 90.0 17.3 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MTP18 PF10558.9 EGD99766.1 - 6.9e-82 273.5 0.0 1.4e-81 272.5 0.0 1.5 1 1 0 1 1 1 1 Mitochondrial 18 KDa protein (MTP18) ATP19 PF11022.8 EGD99767.1 - 1.1e-25 89.8 0.1 1.3e-25 89.6 0.1 1.1 1 0 0 1 1 1 1 ATP synthase subunit K AAT PF03417.16 EGD99768.1 - 2.2e-30 106.1 0.0 2.9e-30 105.7 0.0 1.2 1 0 0 1 1 1 1 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase ACPS PF01648.20 EGD99769.1 - 1.5e-14 54.1 0.0 1.9e-14 53.8 0.0 1.1 1 0 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily 4PPT_N PF17837.1 EGD99769.1 - 0.085 13.0 4.3 0.71 10.0 2.6 2.6 2 1 0 2 2 2 0 4'-phosphopantetheinyl transferase N-terminal domain APH PF01636.23 EGD99770.1 - 5.1e-13 49.5 0.0 1.2e-12 48.3 0.0 1.6 1 1 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 EGD99770.1 - 0.036 13.4 0.0 1.4 8.2 0.0 2.7 3 0 0 3 3 3 0 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 EGD99770.1 - 0.067 12.8 0.0 0.16 11.5 0.0 1.7 1 0 0 1 1 1 0 Choline/ethanolamine kinase EcKinase PF02958.20 EGD99770.1 - 0.067 12.5 0.1 0.32 10.3 0.0 2.0 2 1 0 2 2 2 0 Ecdysteroid kinase DUF1679 PF07914.11 EGD99770.1 - 0.078 11.8 0.0 0.21 10.4 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1679) Rib PF08428.10 EGD99771.1 - 0.053 13.5 0.1 0.1 12.6 0.1 1.4 1 0 0 1 1 1 0 Rib/alpha-like repeat F-box PF00646.33 EGD99772.1 - 0.0051 16.7 0.2 0.014 15.2 0.2 1.7 1 0 0 1 1 1 1 F-box domain F-box_4 PF15966.5 EGD99772.1 - 0.006 16.5 0.1 0.013 15.4 0.1 1.5 1 0 0 1 1 1 1 F-box F-box-like PF12937.7 EGD99772.1 - 0.38 10.7 0.1 0.38 10.7 0.1 1.9 2 0 0 2 2 2 0 F-box-like PHP PF02811.19 EGD99773.1 - 1.5e-11 44.9 0.0 2.2e-11 44.4 0.0 1.2 1 0 0 1 1 1 1 PHP domain IFP_35_N PF07334.13 EGD99773.1 - 0.12 12.5 0.1 0.25 11.4 0.1 1.5 1 0 0 1 1 1 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus AA_permease PF00324.21 EGD99774.1 - 1.7e-32 112.7 14.9 1.9e-32 112.5 14.9 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EGD99774.1 - 5e-08 32.2 13.7 5.8e-08 32.0 13.7 1.0 1 0 0 1 1 1 1 Amino acid permease TraT PF05818.12 EGD99774.1 - 0.19 11.4 0.5 0.25 11.0 0.5 1.1 1 0 0 1 1 1 0 Enterobacterial TraT complement resistance protein FKBP_C PF00254.28 EGD99777.1 - 3.4e-21 75.4 0.0 3.9e-21 75.2 0.0 1.0 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase F-box PF00646.33 EGD99778.1 - 0.00043 20.1 1.2 0.0013 18.6 1.2 1.8 1 0 0 1 1 1 1 F-box domain F-box_4 PF15966.5 EGD99778.1 - 0.018 14.9 0.4 0.042 13.7 0.4 1.7 1 0 0 1 1 1 0 F-box DUF3455 PF11937.8 EGD99778.1 - 0.11 12.8 0.0 0.18 12.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3455) EAP30 PF04157.16 EGD99780.1 - 3.8e-41 140.9 1.2 4.9e-41 140.6 1.2 1.1 1 0 0 1 1 1 1 EAP30/Vps36 family Vps36-NZF-N PF16988.5 EGD99780.1 - 1.1e-21 75.9 1.5 1.1e-21 75.9 1.5 2.6 2 1 0 2 2 2 1 Vacuolar protein sorting 36 NZF-N zinc-finger domain Vps36_ESCRT-II PF11605.8 EGD99780.1 - 2.4e-21 75.7 0.0 5.8e-21 74.5 0.0 1.6 2 0 0 2 2 2 1 Vacuolar protein sorting protein 36 Vps36 zf-Sec23_Sec24 PF04810.15 EGD99780.1 - 0.00014 21.8 4.9 0.002 18.1 0.1 3.3 3 0 0 3 3 3 1 Sec23/Sec24 zinc finger zf-RanBP PF00641.18 EGD99780.1 - 0.0018 17.6 9.5 0.0041 16.4 0.2 2.8 3 0 0 3 3 3 2 Zn-finger in Ran binding protein and others zf-MIZ PF02891.20 EGD99780.1 - 0.041 13.6 0.1 0.1 12.3 0.1 1.7 1 0 0 1 1 1 0 MIZ/SP-RING zinc finger GRAM PF02893.20 EGD99780.1 - 0.044 13.7 0.0 0.09 12.7 0.0 1.5 1 0 0 1 1 1 0 GRAM domain Cas_CXXC_CXXC PF09706.10 EGD99780.1 - 0.17 12.2 0.1 18 5.7 0.0 2.6 2 0 0 2 2 2 0 CRISPR-associated protein (Cas_CXXC_CXXC) SAC3_GANP PF03399.16 EGD99781.1 - 3.1e-11 43.2 0.9 2e-09 37.3 0.2 2.3 1 1 1 2 2 2 2 SAC3/GANP family SH3_1 PF00018.28 EGD99782.1 - 1.5e-25 88.5 1.5 1.9e-11 43.4 0.0 3.3 3 0 0 3 3 3 2 SH3 domain SH3_9 PF14604.6 EGD99782.1 - 2.7e-14 52.7 2.5 4.3e-06 26.5 0.0 2.9 3 0 0 3 3 3 2 Variant SH3 domain PX PF00787.24 EGD99782.1 - 2.3e-13 50.1 0.0 4.2e-13 49.3 0.0 1.4 1 0 0 1 1 1 1 PX domain SH3_2 PF07653.17 EGD99782.1 - 5e-11 42.1 0.0 5.9e-06 25.9 0.0 2.7 2 0 0 2 2 2 2 Variant SH3 domain PB1 PF00564.24 EGD99782.1 - 4.2e-06 26.6 0.3 8.5e-06 25.6 0.3 1.5 1 0 0 1 1 1 1 PB1 domain IHABP4_N PF16174.5 EGD99782.1 - 0.38 11.4 0.1 0.38 11.4 0.1 2.8 3 0 0 3 3 3 0 Intracellular hyaluronan-binding protein 4 N-terminal AFG1_ATPase PF03969.16 EGD99783.1 - 1.3e-93 313.8 0.0 2.3e-88 296.6 0.0 2.1 2 0 0 2 2 2 2 AFG1-like ATPase AAA_16 PF13191.6 EGD99783.1 - 0.00037 20.9 0.2 0.19 12.1 0.0 3.0 2 2 0 2 2 2 1 AAA ATPase domain AAA_14 PF13173.6 EGD99783.1 - 0.0017 18.4 0.0 0.0034 17.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 EGD99783.1 - 0.0043 17.5 0.0 0.019 15.4 0.0 2.1 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EGD99783.1 - 0.038 14.3 0.0 0.17 12.1 0.0 2.2 2 1 0 2 2 2 0 AAA domain TsaE PF02367.17 EGD99783.1 - 0.12 12.4 0.0 0.24 11.4 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Mg_chelatase PF01078.21 EGD99783.1 - 0.17 11.3 0.0 0.65 9.3 0.0 1.8 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI Chitin_synth_1 PF01644.17 EGD99784.1 - 9.2e-72 240.3 0.0 1.9e-71 239.3 0.0 1.5 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_2 PF03142.15 EGD99784.1 - 1.8e-23 83.0 3.1 5.4e-21 74.8 0.0 2.1 1 1 1 2 2 2 1 Chitin synthase Glyco_trans_2_3 PF13632.6 EGD99784.1 - 7.6e-07 29.2 0.3 7.6e-07 29.2 0.3 1.9 2 0 0 2 2 2 1 Glycosyl transferase family group 2 Chitin_synth_1N PF08407.11 EGD99784.1 - 2e-05 24.5 0.0 5.3e-05 23.1 0.0 1.7 1 0 0 1 1 1 1 Chitin synthase N-terminal Glyco_tranf_2_3 PF13641.6 EGD99784.1 - 0.076 12.9 0.0 0.17 11.7 0.0 1.5 2 0 0 2 2 2 0 Glycosyltransferase like family 2 dCMP_cyt_deam_1 PF00383.23 EGD99785.1 - 3.2e-06 26.9 0.0 4.5e-06 26.5 0.0 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region DUF1774 PF08611.10 EGD99786.1 - 3.2e-30 104.3 1.7 3.2e-30 104.3 1.7 2.0 2 0 0 2 2 2 1 Fungal protein of unknown function (DUF1774) Peptidase_M28 PF04389.17 EGD99787.1 - 5.1e-25 88.3 0.0 1.1e-24 87.3 0.0 1.6 1 0 0 1 1 1 1 Peptidase family M28 R3H-assoc PF13902.6 EGD99788.1 - 4e-26 92.0 9.8 4e-26 92.0 9.8 1.7 2 0 0 2 2 2 1 R3H-associated N-terminal domain R3H PF01424.22 EGD99788.1 - 0.005 16.8 0.0 0.11 12.4 0.0 2.5 2 0 0 2 2 2 1 R3H domain STAT_int PF02865.17 EGD99788.1 - 0.07 13.6 0.1 0.13 12.7 0.1 1.5 1 0 0 1 1 1 0 STAT protein, protein interaction domain LppA PF16708.5 EGD99788.1 - 0.082 12.8 0.9 0.41 10.6 0.6 2.1 1 1 1 2 2 2 0 Lipoprotein confined to pathogenic Mycobacterium Hist_deacetyl PF00850.19 EGD99789.1 - 1.4e-49 169.3 0.0 3.1e-49 168.1 0.0 1.6 1 0 0 1 1 1 1 Histone deacetylase domain zf-AN1 PF01428.16 EGD99790.1 - 8.4e-24 83.5 25.6 2e-12 47.0 9.5 2.2 2 0 0 2 2 2 2 AN1-like Zinc finger IBR PF01485.21 EGD99790.1 - 0.38 11.0 25.1 0.34 11.2 8.5 3.3 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain Transp_Tc5_C PF04236.15 EGD99790.1 - 0.47 10.8 16.4 0.22 11.9 4.9 2.4 2 0 0 2 2 2 0 Tc5 transposase C-terminal domain Zn-ribbon_8 PF09723.10 EGD99790.1 - 6.5 7.0 11.1 2.3 8.4 2.7 2.6 2 0 0 2 2 2 0 Zinc ribbon domain C1_4 PF07975.12 EGD99790.1 - 8.4 6.7 19.0 2.5 8.4 7.3 3.1 2 2 0 2 2 2 0 TFIIH C1-like domain Thymidylat_synt PF00303.19 EGD99791.1 - 1.7e-104 348.7 0.0 1.9e-104 348.5 0.0 1.0 1 0 0 1 1 1 1 Thymidylate synthase TGT PF01702.18 EGD99792.1 - 7.2e-145 482.5 0.0 8.6e-145 482.3 0.0 1.0 1 0 0 1 1 1 1 Queuine tRNA-ribosyltransferase Fungal_trans PF04082.18 EGD99793.1 - 7.3e-16 58.0 0.1 2.2e-15 56.4 0.1 1.9 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EGD99793.1 - 1.1e-09 38.3 12.7 2.5e-09 37.1 12.7 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CCDC53 PF10152.9 EGD99793.1 - 0.4 11.1 2.1 0.97 9.8 2.1 1.6 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex Spt20 PF12090.8 EGD99793.1 - 7.1 6.2 9.8 12 5.5 9.8 1.2 1 0 0 1 1 1 0 Spt20 family DND1_DSRM PF14709.7 EGD99794.1 - 0.0061 16.8 0.1 0.018 15.3 0.1 1.7 1 1 0 1 1 1 1 double strand RNA binding domain from DEAD END PROTEIN 1 dsRBD2 PF17842.1 EGD99794.1 - 0.084 13.1 0.0 0.1 12.8 0.0 1.2 1 0 0 1 1 1 0 Double-stranded RNA binding domain 2 Glyco_hydro_18 PF00704.28 EGD99797.1 - 1.5e-58 199.0 0.0 2.6e-58 198.2 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Interferon PF00143.19 EGD99797.1 - 0.17 12.0 0.1 0.3 11.3 0.1 1.3 1 0 0 1 1 1 0 Interferon alpha/beta domain Metallophos PF00149.28 EGD99798.1 - 3.9e-13 50.4 6.5 8e-13 49.4 6.5 1.4 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Acyltransferase PF01553.21 EGD99798.1 - 0.12 11.9 0.1 0.24 11.0 0.1 1.4 1 0 0 1 1 1 0 Acyltransferase U79_P34 PF03064.16 EGD99799.1 - 0.58 9.5 9.3 1.1 8.5 9.3 1.4 1 0 0 1 1 1 0 HSV U79 / HCMV P34 Ala_racemase_N PF01168.20 EGD99801.1 - 8.2e-21 74.7 0.0 1.1e-20 74.2 0.0 1.1 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain Adaptin_N PF01602.20 EGD99802.1 - 1.1e-124 416.9 4.8 1.4e-124 416.6 4.8 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptin_C PF02296.16 EGD99802.1 - 3.8e-41 139.8 0.0 8.7e-41 138.7 0.0 1.7 1 0 0 1 1 1 1 Alpha adaptin AP2, C-terminal domain Alpha_adaptinC2 PF02883.20 EGD99802.1 - 9.2e-17 61.4 0.0 3.1e-16 59.7 0.0 2.0 2 0 0 2 2 2 1 Adaptin C-terminal domain Cnd1 PF12717.7 EGD99802.1 - 0.0016 18.5 0.7 0.063 13.3 0.0 2.6 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 RIX1 PF08167.12 EGD99802.1 - 0.0081 15.9 0.0 0.63 9.8 0.0 3.1 2 1 0 2 2 2 1 rRNA processing/ribosome biogenesis RasGEF_N_2 PF14663.6 EGD99802.1 - 3.8 7.9 4.8 19 5.7 0.0 3.3 3 0 0 3 3 3 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain Homeodomain PF00046.29 EGD99804.1 - 1.2e-16 60.3 3.4 2.3e-16 59.4 3.4 1.4 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EGD99804.1 - 0.07 13.0 0.8 0.14 12.1 0.1 1.8 2 0 0 2 2 2 0 Homeobox KN domain RHH_1 PF01402.21 EGD99806.1 - 0.075 13.0 0.2 0.17 11.9 0.2 1.5 1 0 0 1 1 1 0 Ribbon-helix-helix protein, copG family efThoc1 PF11957.8 EGD99807.1 - 3.5e-155 517.4 6.8 4.5e-155 517.1 6.8 1.0 1 0 0 1 1 1 1 THO complex subunit 1 transcription elongation factor Aquarius_N PF16399.5 EGD99808.1 - 0 1096.1 0.0 0 1095.8 0.0 1.1 1 0 0 1 1 1 1 Intron-binding protein aquarius N-terminus AAA_12 PF13087.6 EGD99808.1 - 2.4e-25 89.4 0.0 4.1e-25 88.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 EGD99808.1 - 1.1e-22 81.1 0.0 3.9e-22 79.3 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EGD99808.1 - 2.8e-07 30.5 0.0 8e-05 22.4 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 EGD99808.1 - 1.3e-06 28.8 0.0 2.6e-06 27.8 0.0 1.6 1 1 0 1 1 1 1 AAA domain ResIII PF04851.15 EGD99808.1 - 5.8e-06 26.4 0.0 1.3e-05 25.3 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Viral_helicase1 PF01443.18 EGD99808.1 - 0.00041 20.2 0.1 0.4 10.4 0.0 2.9 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase AAA_16 PF13191.6 EGD99808.1 - 0.00074 19.9 0.1 0.0039 17.6 0.0 2.2 2 0 0 2 2 2 1 AAA ATPase domain UvrD-helicase PF00580.21 EGD99808.1 - 0.0019 17.8 0.1 0.0062 16.1 0.0 1.9 2 0 0 2 2 2 1 UvrD/REP helicase N-terminal domain DnaB_C PF03796.15 EGD99808.1 - 0.0025 17.2 0.0 0.0057 16.0 0.0 1.6 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain AAA PF00004.29 EGD99808.1 - 0.0032 17.9 0.0 0.012 16.1 0.0 2.0 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) PIF1 PF05970.14 EGD99808.1 - 0.0075 15.5 0.0 0.77 8.9 0.0 2.2 2 0 0 2 2 2 1 PIF1-like helicase Adeno_IVa2 PF02456.15 EGD99808.1 - 0.016 14.0 0.0 0.045 12.5 0.0 1.7 1 0 0 1 1 1 0 Adenovirus IVa2 protein AAA_22 PF13401.6 EGD99808.1 - 0.023 15.0 0.6 0.24 11.7 0.2 2.6 1 1 1 2 2 2 0 AAA domain DUF2075 PF09848.9 EGD99808.1 - 0.023 13.9 1.0 0.044 13.0 0.0 1.8 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) DEAD PF00270.29 EGD99808.1 - 0.026 14.3 0.0 0.097 12.4 0.0 2.0 2 0 0 2 2 2 0 DEAD/DEAH box helicase AAA_7 PF12775.7 EGD99808.1 - 0.053 13.0 0.0 0.14 11.7 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_5 PF07728.14 EGD99808.1 - 0.075 13.0 0.0 0.29 11.1 0.0 2.0 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) UvrD_C_2 PF13538.6 EGD99808.1 - 0.083 12.7 0.1 0.18 11.6 0.1 1.6 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain ATPase_2 PF01637.18 EGD99808.1 - 0.089 12.7 0.0 0.17 11.8 0.0 1.4 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea 4HBT PF03061.22 EGD99809.1 - 0.00016 21.9 0.1 0.0064 16.8 0.0 2.4 1 1 1 2 2 2 2 Thioesterase superfamily PBECR2 PF18810.1 EGD99809.1 - 0.036 14.4 0.0 0.05 13.9 0.0 1.2 1 0 0 1 1 1 0 phage-Barnase-EndoU-ColicinE5/D-RelE like nuclease2 DUF4442 PF14539.6 EGD99809.1 - 0.14 12.3 0.0 0.46 10.6 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4442) APH PF01636.23 EGD99811.1 - 2.2e-15 57.3 0.3 3.7e-15 56.5 0.3 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Fructosamin_kin PF03881.14 EGD99811.1 - 0.009 15.3 0.0 0.018 14.3 0.0 1.4 1 0 0 1 1 1 1 Fructosamine kinase tRNA-synt_1b PF00579.25 EGD99812.1 - 1.9e-24 86.5 0.0 3.1e-24 85.8 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) 14-3-3 PF00244.20 EGD99813.1 - 3.3e-08 33.3 0.1 5.2e-08 32.7 0.1 1.3 1 0 0 1 1 1 1 14-3-3 protein Acyl-CoA_dh_1 PF00441.24 EGD99814.1 - 2.4e-33 115.4 0.5 3.4e-33 115.0 0.5 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 EGD99814.1 - 5e-22 77.9 0.0 8.3e-22 77.2 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 EGD99814.1 - 2.7e-13 50.6 0.1 1.1e-12 48.6 0.1 2.1 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 EGD99814.1 - 5e-05 23.6 0.0 7.1e-05 23.1 0.0 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Fungal_trans PF04082.18 EGD99815.1 - 1.4e-13 50.5 0.0 2.4e-13 49.7 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EGD99815.1 - 6.3e-05 23.0 11.0 0.00012 22.1 11.0 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain HpcH_HpaI PF03328.14 EGD99816.1 - 1.3e-32 112.8 0.0 1.7e-32 112.4 0.0 1.1 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family PEP_mutase PF13714.6 EGD99816.1 - 0.015 14.8 0.2 0.96 8.8 0.0 2.5 2 0 0 2 2 2 0 Phosphoenolpyruvate phosphomutase Phage_TAC_10 PF10963.8 EGD99816.1 - 0.084 13.1 0.1 0.45 10.7 0.1 2.0 1 1 0 1 1 1 0 Phage tail assembly chaperone CHORD PF04968.12 EGD99817.1 - 1.8e-50 169.5 20.4 9.8e-26 90.3 7.1 2.2 2 0 0 2 2 2 2 CHORD CS PF04969.16 EGD99817.1 - 3.4e-13 50.4 0.1 5.1e-13 49.8 0.1 1.3 1 0 0 1 1 1 1 CS domain BTK PF00779.19 EGD99817.1 - 0.26 11.1 8.9 3.2 7.6 0.3 3.2 3 0 0 3 3 3 0 BTK motif Choline_kinase PF01633.20 EGD99818.1 - 8.5e-45 152.9 0.0 1.1e-43 149.3 0.0 2.1 2 0 0 2 2 2 1 Choline/ethanolamine kinase APH PF01636.23 EGD99818.1 - 6.2e-08 32.9 0.5 1.8e-07 31.4 0.1 2.0 2 0 0 2 2 2 1 Phosphotransferase enzyme family Voldacs PF03517.13 EGD99819.1 - 0.1 12.8 8.7 0.14 12.2 8.7 1.2 1 0 0 1 1 1 0 Regulator of volume decrease after cellular swelling DUF3050 PF11251.8 EGD99819.1 - 0.15 11.7 2.0 3.4 7.2 0.4 2.9 2 1 0 3 3 3 0 Protein of unknown function (DUF3050) RNA_pol_3_Rpc31 PF11705.8 EGD99819.1 - 0.27 11.4 9.0 0.37 11.0 9.0 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 Sod_Cu PF00080.20 EGD99820.1 - 4.4e-09 36.6 0.0 7.2e-09 36.0 0.0 1.2 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) DUF3405 PF11885.8 EGD99822.1 - 6.6e-231 767.4 0.7 8e-231 767.1 0.7 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3405) Mucin15 PF15672.5 EGD99823.1 - 0.0032 17.0 4.0 0.0032 17.0 4.0 2.2 2 1 0 2 2 2 1 Cell-membrane associated Mucin15 SARAF PF06682.12 EGD99823.1 - 0.022 14.4 0.5 0.034 13.8 0.5 1.3 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis Arf PF00025.21 EGD99827.1 - 2.9e-79 264.6 0.1 3.3e-79 264.4 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 EGD99827.1 - 8.2e-15 54.7 0.0 1e-14 54.4 0.0 1.0 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.13 EGD99827.1 - 2e-14 53.8 0.1 2.7e-14 53.4 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 EGD99827.1 - 3.3e-13 49.6 1.7 2.1e-09 37.0 0.4 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.22 EGD99827.1 - 3.6e-13 49.4 0.0 4e-13 49.3 0.0 1.0 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 EGD99827.1 - 1.8e-10 40.6 0.0 2.1e-10 40.3 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EGD99827.1 - 3.3e-06 27.1 0.0 4.8e-06 26.6 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.18 EGD99827.1 - 0.0079 15.5 0.5 0.021 14.2 0.5 1.8 1 1 0 1 1 1 1 6-phosphofructo-2-kinase CRISPR_Cas2 PF09827.9 EGD99827.1 - 0.025 14.8 0.0 0.044 14.0 0.0 1.4 1 0 0 1 1 1 0 CRISPR associated protein Cas2 Tachylectin PF14517.6 EGD99827.1 - 0.11 12.0 0.0 0.17 11.4 0.0 1.3 1 0 0 1 1 1 0 Tachylectin Acetyltransf_1 PF00583.25 EGD99828.1 - 1.1e-11 44.9 0.0 1.7e-11 44.3 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EGD99828.1 - 4.3e-08 33.1 0.0 3.1e-07 30.4 0.0 2.1 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EGD99828.1 - 5.2e-08 33.2 0.0 7.6e-08 32.7 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EGD99828.1 - 2.2e-06 27.6 0.0 1.7e-05 24.7 0.0 2.2 2 0 0 2 2 2 1 FR47-like protein Acetyltransf_3 PF13302.7 EGD99828.1 - 0.00079 20.1 0.0 0.0012 19.5 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 EGD99828.1 - 0.011 15.5 0.0 0.022 14.4 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 EGD99828.1 - 0.046 13.9 0.0 0.081 13.1 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 EGD99828.1 - 0.14 12.3 0.0 0.32 11.2 0.0 1.5 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase Ribosomal_L1 PF00687.21 EGD99829.1 - 3.5e-47 160.8 0.2 3.9e-47 160.6 0.2 1.0 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family DUF3671 PF12420.8 EGD99829.1 - 0.08 13.0 0.5 0.73 9.9 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function DHQS PF01959.16 EGD99830.1 - 0.099 11.5 0.3 0.14 11.0 0.3 1.2 1 0 0 1 1 1 0 3-dehydroquinate synthase II DUF3593 PF12159.8 EGD99830.1 - 0.12 12.4 0.2 0.23 11.5 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3593) WH2 PF02205.20 EGD99831.1 - 2.4e-09 36.7 0.2 2.4e-09 36.7 0.2 1.9 2 0 0 2 2 2 1 WH2 motif LSM PF01423.22 EGD99832.1 - 6.1e-17 61.1 0.1 8e-17 60.7 0.1 1.2 1 0 0 1 1 1 1 LSM domain SURF4 PF02077.15 EGD99834.1 - 6.9e-94 314.4 7.0 7.9e-94 314.2 7.0 1.0 1 0 0 1 1 1 1 SURF4 family DUF1405 PF07187.11 EGD99834.1 - 0.0096 15.9 3.0 0.0096 15.9 3.0 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF1405) UPF0139 PF03669.13 EGD99834.1 - 0.043 13.7 0.7 0.043 13.7 0.7 2.3 2 1 1 3 3 3 0 Uncharacterised protein family (UPF0139) DoxX PF07681.12 EGD99834.1 - 0.094 13.3 20.6 0.11 13.2 5.1 3.1 3 2 0 3 3 3 0 DoxX Oxidored_q2 PF00420.24 EGD99836.1 - 0.049 13.3 0.0 0.094 12.4 0.0 1.4 1 0 0 1 1 1 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L Amidase PF01425.21 EGD99837.1 - 1.7e-94 317.4 0.0 2.7e-94 316.7 0.0 1.3 1 1 0 1 1 1 1 Amidase Glycos_transf_1 PF00534.20 EGD99838.1 - 4.6e-13 49.1 0.0 8.4e-13 48.2 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 EGD99838.1 - 1.2e-07 32.3 0.0 2.4e-07 31.3 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.6 EGD99838.1 - 0.068 13.6 0.0 0.21 12.0 0.0 1.8 2 0 0 2 2 2 0 Glycosyl transferases group 1 HLH PF00010.26 EGD99840.1 - 1.3e-11 44.3 0.4 3.7e-11 42.8 0.4 1.8 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Spt20 PF12090.8 EGD99840.1 - 0.0038 16.9 20.7 0.0065 16.1 20.7 1.3 1 0 0 1 1 1 1 Spt20 family GDH_N PF12466.8 EGD99840.1 - 0.067 13.4 0.2 0.067 13.4 0.2 2.0 2 0 0 2 2 2 0 Glutamate dehydrogenase N terminal DUF2722 PF10846.8 EGD99840.1 - 0.27 10.1 19.8 0.038 12.9 15.8 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) Presenilin PF01080.17 EGD99840.1 - 0.42 9.3 10.0 0.66 8.7 10.0 1.3 1 0 0 1 1 1 0 Presenilin Ndc1_Nup PF09531.10 EGD99840.1 - 0.59 8.7 12.0 0.63 8.7 12.0 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup TFIIA PF03153.13 EGD99840.1 - 1.3 8.9 31.8 0.98 9.3 30.6 1.4 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DivIC PF04977.15 EGD99840.1 - 2.5 7.9 9.0 4 7.3 7.1 2.2 2 0 0 2 2 2 0 Septum formation initiator PAT1 PF09770.9 EGD99840.1 - 5 5.3 21.6 7.1 4.8 21.6 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF4407 PF14362.6 EGD99840.1 - 5.4 6.3 9.1 9 5.5 9.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) SLC12 PF03522.15 EGD99840.1 - 5.5 5.9 10.2 8.6 5.3 10.2 1.2 1 0 0 1 1 1 0 Solute carrier family 12 ALMT PF11744.8 EGD99840.1 - 6 5.6 7.4 9.7 4.9 7.4 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF908 PF06012.12 EGD99840.1 - 6.9 6.0 14.7 0.17 11.2 7.8 1.7 2 0 0 2 2 2 0 Domain of Unknown Function (DUF908) RR_TM4-6 PF06459.12 EGD99840.1 - 8.2 6.2 11.6 16 5.2 11.6 1.5 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 IU_nuc_hydro PF01156.19 EGD99841.1 - 5.7e-58 196.9 0.0 7.5e-58 196.5 0.0 1.1 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase Transketolase_C PF02780.20 EGD99841.1 - 0.001 18.9 0.2 0.042 13.7 0.0 2.5 2 0 0 2 2 2 1 Transketolase, C-terminal domain Fungal_trans PF04082.18 EGD99843.1 - 2.1e-15 56.5 0.7 3.2e-15 55.9 0.7 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EGD99843.1 - 7e-08 32.5 9.2 1.6e-07 31.4 9.2 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain NIP_1 PF08995.10 EGD99843.1 - 0.17 12.3 4.4 32 5.0 0.0 2.7 2 1 1 3 3 3 0 Necrosis inducing protein-1 p450 PF00067.22 EGD99844.1 - 7e-39 133.8 0.0 9.4e-39 133.4 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 FA_hydroxylase PF04116.13 EGD99845.1 - 1.9e-19 70.3 15.9 1.1e-18 67.8 13.3 2.8 2 1 0 2 2 2 1 Fatty acid hydroxylase superfamily Arylsulfotran_2 PF14269.6 EGD99846.1 - 3.2e-109 364.9 1.1 4.7e-109 364.4 1.1 1.2 1 0 0 1 1 1 1 Arylsulfotransferase (ASST) p450 PF00067.22 EGD99847.1 - 4.3e-57 193.9 0.0 5.7e-55 186.9 0.0 2.0 1 1 0 1 1 1 1 Cytochrome P450 Peptidase_S8 PF00082.22 EGD99848.1 - 4.2e-29 101.7 10.9 6.8e-29 101.1 10.9 1.3 1 0 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 EGD99848.1 - 2.6e-14 53.6 0.0 4.7e-14 52.8 0.0 1.4 1 0 0 1 1 1 1 Peptidase inhibitor I9 Peptidase_M14 PF00246.24 EGD99850.1 - 1.9e-82 277.3 0.1 4.5e-82 276.1 0.0 1.6 2 0 0 2 2 2 1 Zinc carboxypeptidase Propep_M14 PF02244.16 EGD99850.1 - 2.7e-11 43.7 0.1 5.8e-11 42.6 0.1 1.6 1 0 0 1 1 1 1 Carboxypeptidase activation peptide AstE_AspA PF04952.14 EGD99850.1 - 0.11 11.5 0.0 0.17 11.0 0.0 1.2 1 0 0 1 1 1 0 Succinylglutamate desuccinylase / Aspartoacylase family Fungal_trans PF04082.18 EGD99851.1 - 5.8e-14 51.8 0.0 1.1e-13 50.9 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EGD99851.1 - 5.9e-08 32.7 13.0 1.2e-07 31.7 13.0 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain GARP PF16731.5 EGD99851.1 - 0.065 12.9 0.8 0.12 12.0 0.8 1.4 1 0 0 1 1 1 0 Glutamic acid/alanine-rich protein of Trypanosoma SOG2 PF10428.9 EGD99851.1 - 0.086 12.0 9.1 0.18 11.0 9.1 1.5 1 0 0 1 1 1 0 RAM signalling pathway protein Rox3 PF08633.10 EGD99852.1 - 1.9e-66 224.3 1.1 2.3e-66 224.0 0.2 1.5 2 0 0 2 2 2 1 Rox3 mediator complex subunit HAD_2 PF13419.6 EGD99853.1 - 2.7e-06 27.6 0.0 1e-05 25.7 0.0 1.9 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EGD99853.1 - 2e-05 25.0 0.0 2.7e-05 24.6 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Thr_synth_N PF14821.6 EGD99854.1 - 1.7e-27 95.4 0.0 6.2e-27 93.6 0.0 2.0 2 0 0 2 2 2 1 Threonine synthase N terminus PALP PF00291.25 EGD99854.1 - 3.8e-16 59.4 0.0 5.5e-15 55.6 0.0 2.0 1 1 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme DUF4202 PF13875.6 EGD99855.1 - 3.3e-74 248.8 1.7 3.9e-74 248.6 1.7 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4202) ADD_DNMT3 PF17980.1 EGD99855.1 - 0.12 12.4 0.1 0.24 11.4 0.1 1.5 1 0 0 1 1 1 0 Cysteine rich ADD domain in DNMT3 2-ph_phosp PF04029.14 EGD99855.1 - 0.13 11.4 0.3 2.9 7.0 0.1 2.1 2 0 0 2 2 2 0 2-phosphosulpholactate phosphatase VIT1 PF01988.19 EGD99856.1 - 1.8e-60 204.5 2.7 2.1e-60 204.2 2.7 1.0 1 0 0 1 1 1 1 VIT family 7TMR-DISM_7TM PF07695.11 EGD99856.1 - 0.0014 18.6 0.7 0.002 18.0 0.7 1.2 1 0 0 1 1 1 1 7TM diverse intracellular signalling Med13_C PF06333.12 EGD99857.1 - 0.11 11.7 1.9 0.11 11.7 1.9 1.0 1 0 0 1 1 1 0 Mediator complex subunit 13 C-terminal domain VPS9 PF02204.18 EGD99859.1 - 1.5e-30 105.4 0.1 2.8e-30 104.6 0.1 1.4 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain DUF5601 PF18151.1 EGD99859.1 - 1.1e-16 60.9 0.1 3.1e-16 59.4 0.1 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF5601) CUE PF02845.16 EGD99859.1 - 8.2e-09 35.0 0.2 2.1e-07 30.5 0.0 2.4 2 0 0 2 2 2 1 CUE domain Asn_synthase PF00733.21 EGD99860.1 - 4.1e-12 46.4 0.2 4.3e-05 23.4 0.0 2.1 1 1 1 2 2 2 2 Asparagine synthase GATase_7 PF13537.6 EGD99860.1 - 1e-07 31.9 0.0 2.1e-07 30.9 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain DUF3700 PF12481.8 EGD99860.1 - 0.004 16.6 0.0 0.0071 15.8 0.0 1.3 1 0 0 1 1 1 1 Aluminium induced protein GATase_6 PF13522.6 EGD99860.1 - 0.012 15.8 0.0 0.026 14.7 0.0 1.5 1 0 0 1 1 1 0 Glutamine amidotransferase domain bZIP_2 PF07716.15 EGD99861.1 - 1.4e-07 31.5 8.2 3.6e-07 30.2 8.2 1.7 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.21 EGD99861.1 - 1.5e-07 31.4 7.7 3.2e-07 30.3 7.7 1.4 1 0 0 1 1 1 1 bZIP transcription factor Sugarporin_N PF11471.8 EGD99861.1 - 0.014 15.3 5.2 0.042 13.8 5.2 1.7 1 0 0 1 1 1 0 Maltoporin periplasmic N-terminal extension ASD2 PF08687.11 EGD99861.1 - 0.019 14.6 0.8 0.037 13.6 0.8 1.4 1 0 0 1 1 1 0 Apx/Shroom domain ASD2 bZIP_Maf PF03131.17 EGD99861.1 - 0.025 15.1 7.1 0.077 13.5 7.1 1.7 1 0 0 1 1 1 0 bZIP Maf transcription factor DUF4094 PF13334.6 EGD99861.1 - 0.15 12.5 0.7 0.37 11.3 0.7 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4094) PNTB PF02233.16 EGD99862.1 - 4e-163 543.6 35.9 1.9e-158 528.2 26.4 2.9 3 0 0 3 3 3 2 NAD(P) transhydrogenase beta subunit AlaDh_PNT_C PF01262.21 EGD99862.1 - 1.8e-71 239.9 0.9 4.6e-71 238.5 0.4 2.0 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain AlaDh_PNT_N PF05222.15 EGD99862.1 - 1.3e-33 116.2 0.0 3.5e-33 114.8 0.0 1.7 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain PNTB_4TM PF12769.7 EGD99862.1 - 4.4e-30 104.0 3.0 4.4e-30 104.0 3.0 5.3 3 1 1 5 5 5 1 4TM region of pyridine nucleotide transhydrogenase, mitoch 2-Hacid_dh_C PF02826.19 EGD99862.1 - 0.00077 18.9 1.1 1.2 8.4 0.1 3.3 3 0 0 3 3 3 2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Pyr_redox_2 PF07992.14 EGD99862.1 - 0.03 13.5 1.1 0.049 12.8 0.2 1.8 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase TPP_enzyme_M PF00205.22 EGD99862.1 - 0.032 14.0 0.8 0.18 11.5 0.4 2.5 2 1 0 2 2 2 0 Thiamine pyrophosphate enzyme, central domain ADH_zinc_N PF00107.26 EGD99862.1 - 0.066 13.2 0.5 0.28 11.2 0.1 2.3 2 0 0 2 2 2 0 Zinc-binding dehydrogenase GIDA PF01134.22 EGD99862.1 - 0.082 12.0 0.6 0.16 11.0 0.6 1.5 1 0 0 1 1 1 0 Glucose inhibited division protein A NAD_binding_8 PF13450.6 EGD99862.1 - 2.1 8.6 6.4 0.7 10.2 1.5 3.0 2 1 0 2 2 2 0 NAD(P)-binding Rossmann-like domain PH_6 PF15406.6 EGD99863.1 - 1.8e-30 105.5 1.1 1.8e-30 105.5 1.1 3.4 3 1 0 3 3 3 1 Pleckstrin homology domain PH PF00169.29 EGD99863.1 - 8.4e-10 39.1 0.0 2.4e-09 37.6 0.0 1.8 1 0 0 1 1 1 1 PH domain Sulfate_transp PF00916.20 EGD99865.1 - 8.3e-61 205.8 22.2 1.5e-60 205.0 22.2 1.3 1 0 0 1 1 1 1 Sulfate permease family cNMP_binding PF00027.29 EGD99865.1 - 1.8e-14 53.5 0.0 3.6e-14 52.6 0.0 1.5 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain STAS PF01740.21 EGD99865.1 - 1.3e-11 44.1 0.1 2.5e-11 43.3 0.1 1.4 1 0 0 1 1 1 1 STAS domain Sld5 PF05916.11 EGD99867.1 - 1.1e-12 48.4 0.1 2.5e-12 47.2 0.1 1.6 1 1 0 1 1 1 1 GINS complex protein INT_SG_DDX_CT_C PF15300.6 EGD99867.1 - 0.13 12.1 0.0 0.25 11.2 0.0 1.4 1 0 0 1 1 1 0 INTS6/SAGE1/DDX26B/CT45 C-terminus HMG_box PF00505.19 EGD99868.1 - 2.3e-09 37.5 0.4 4.5e-09 36.6 0.4 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box PAXIP1_C PF15364.6 EGD99868.1 - 0.0058 16.9 0.7 0.014 15.7 0.7 1.6 1 0 0 1 1 1 1 PAXIP1-associated-protein-1 C term PTIP binding protein PHD PF00628.29 EGD99871.1 - 2.9e-09 36.7 12.7 1.9e-08 34.1 10.9 2.4 2 0 0 2 2 2 1 PHD-finger PHD_2 PF13831.6 EGD99871.1 - 0.0028 17.2 6.5 0.0028 17.2 6.5 2.1 2 0 0 2 2 2 1 PHD-finger C1_2 PF03107.16 EGD99871.1 - 0.87 10.0 6.5 0.36 11.2 2.0 2.3 2 0 0 2 2 2 0 C1 domain DUF2252 PF10009.9 EGD99871.1 - 1.6 7.7 12.8 0.83 8.6 10.2 1.7 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2252) Rcd1 PF04078.13 EGD99872.1 - 7.9e-126 418.6 3.5 9.5e-126 418.4 3.5 1.1 1 0 0 1 1 1 1 Cell differentiation family, Rcd1-like CENP-U PF13097.6 EGD99872.1 - 0.17 11.8 6.3 0.31 11.0 6.3 1.3 1 0 0 1 1 1 0 CENP-A nucleosome associated complex (NAC) subunit TFIIA PF03153.13 EGD99872.1 - 0.97 9.4 12.0 1.2 9.0 12.0 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Glycophorin_A PF01102.18 EGD99872.1 - 1.3 9.3 3.5 36 4.6 3.9 2.4 2 0 0 2 2 2 0 Glycophorin A DUF4834 PF16118.5 EGD99873.1 - 0.0056 17.6 0.0 1.4 9.9 0.0 2.4 1 1 0 1 1 1 1 Domain of unknown function (DUF4834) DUF4690 PF15756.5 EGD99873.1 - 0.0086 16.7 1.9 0.027 15.1 1.9 1.9 1 0 0 1 1 1 1 Small Novel Rich in Cartilage Mucin PF01456.17 EGD99874.1 - 0.14 12.2 19.5 0.22 11.5 19.5 1.3 1 0 0 1 1 1 0 Mucin-like glycoprotein DUF390 PF04094.14 EGD99875.1 - 9.6 4.4 8.1 13 4.0 8.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF390) Mito_carr PF00153.27 EGD99876.1 - 9.7e-53 176.1 1.6 7.3e-19 67.5 0.1 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein eRF1_1 PF03463.15 EGD99876.1 - 0.07 13.1 0.0 1.2 9.1 0.0 2.2 2 0 0 2 2 2 0 eRF1 domain 1 DUF508 PF04370.12 EGD99876.1 - 0.55 10.0 4.4 1.2 8.9 4.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF508) PIN_2 PF10130.9 EGD99877.1 - 0.084 13.1 0.1 0.084 13.1 0.1 3.0 2 1 1 3 3 3 0 PIN domain Prefoldin_2 PF01920.20 EGD99879.1 - 2.6e-20 72.3 6.2 3.4e-20 72.0 6.2 1.2 1 0 0 1 1 1 1 Prefoldin subunit Cnn_1N PF07989.11 EGD99879.1 - 0.0047 17.0 1.2 0.0047 17.0 1.2 2.1 2 0 0 2 2 2 1 Centrosomin N-terminal motif 1 T6PP_N PF18572.1 EGD99879.1 - 0.0052 16.6 1.9 0.02 14.7 1.9 1.8 1 1 0 1 1 1 1 Trehalose-6-phosphate phosphatase N-terminal helical bundle domain Fib_alpha PF08702.10 EGD99879.1 - 0.016 15.4 5.8 0.23 11.7 0.2 2.1 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family HAUS-augmin3 PF14932.6 EGD99879.1 - 0.019 14.6 3.7 0.72 9.4 0.5 2.0 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 3 DUF4407 PF14362.6 EGD99879.1 - 0.023 14.1 0.7 0.032 13.6 0.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) ZapB PF06005.12 EGD99879.1 - 0.027 14.9 1.7 0.027 14.9 1.7 2.1 2 0 0 2 2 2 0 Cell division protein ZapB Val_tRNA-synt_C PF10458.9 EGD99879.1 - 0.039 14.2 0.4 0.039 14.2 0.4 2.2 2 0 0 2 2 2 0 Valyl tRNA synthetase tRNA binding arm DUF3450 PF11932.8 EGD99879.1 - 0.049 12.9 5.5 0.67 9.2 1.4 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) DUF724 PF05266.14 EGD99879.1 - 0.06 13.2 2.8 2.7 7.8 0.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF724) DUF2681 PF10883.8 EGD99879.1 - 0.061 13.7 4.9 0.64 10.5 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) Spc24 PF08286.11 EGD99879.1 - 0.07 13.4 3.9 1.3 9.3 0.4 2.1 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 Tektin PF03148.14 EGD99879.1 - 0.08 11.7 6.4 0.15 10.8 0.4 2.0 2 0 0 2 2 2 0 Tektin family FlxA PF14282.6 EGD99879.1 - 0.086 12.8 8.2 1.6 8.8 3.7 2.2 2 0 0 2 2 2 0 FlxA-like protein TMF_TATA_bd PF12325.8 EGD99879.1 - 0.095 12.9 5.3 0.34 11.1 0.3 2.1 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding CdvA PF18822.1 EGD99879.1 - 0.12 12.2 5.8 0.52 10.2 1.4 2.6 2 1 0 2 2 2 0 CdvA-like coiled-coil domain DUF4618 PF15397.6 EGD99879.1 - 0.12 11.8 6.4 0.62 9.4 0.3 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4618) APG6_N PF17675.1 EGD99879.1 - 0.34 11.4 5.9 6 7.4 5.9 2.0 1 1 0 1 1 1 0 Apg6 coiled-coil region PspA_IM30 PF04012.12 EGD99879.1 - 0.35 10.4 8.9 2.4 7.7 2.6 2.1 2 0 0 2 2 2 0 PspA/IM30 family DUF4200 PF13863.6 EGD99879.1 - 0.5 10.8 7.7 4.1 7.8 0.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) Prefoldin PF02996.17 EGD99879.1 - 0.51 10.3 6.5 2.8 7.9 0.1 2.1 2 0 0 2 2 2 0 Prefoldin subunit SlyX PF04102.12 EGD99879.1 - 0.81 10.3 7.4 11 6.7 2.9 2.2 2 0 0 2 2 2 0 SlyX DUF1664 PF07889.12 EGD99879.1 - 1.1 9.4 7.3 0.38 10.8 0.5 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) bZIP_1 PF00170.21 EGD99879.1 - 1.5 9.0 6.4 0.74 10.0 2.4 2.1 2 0 0 2 2 2 0 bZIP transcription factor DivIC PF04977.15 EGD99879.1 - 3 7.7 8.1 5.1 6.9 0.2 2.3 2 0 0 2 2 2 0 Septum formation initiator THOC7 PF05615.13 EGD99879.1 - 3.2 8.1 11.3 7.8 6.8 1.0 2.1 2 0 0 2 2 2 0 Tho complex subunit 7 Swi5 PF07061.11 EGD99879.1 - 4.4 7.5 8.9 5.7 7.1 2.3 2.2 2 0 0 2 2 2 0 Swi5 YabA PF06156.13 EGD99879.1 - 5.3 7.7 8.8 5.4 7.7 1.4 2.1 1 1 1 2 2 2 0 Initiation control protein YabA Toprim PF01751.22 EGD99880.1 - 2.5e-05 24.5 0.0 3.8e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 Toprim domain GMC_oxred_N PF00732.19 EGD99881.1 - 7.8e-46 156.8 0.6 1.2e-45 156.2 0.6 1.3 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EGD99881.1 - 1.6e-29 103.3 0.3 1.6e-28 100.0 0.0 2.3 2 0 0 2 2 2 1 GMC oxidoreductase FAD_binding_2 PF00890.24 EGD99881.1 - 4.5e-07 29.3 0.6 3.4e-05 23.1 0.1 2.2 2 0 0 2 2 2 2 FAD binding domain Pyr_redox_2 PF07992.14 EGD99881.1 - 9.3e-05 21.8 0.2 0.00024 20.5 0.1 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EGD99881.1 - 0.0013 18.0 0.2 0.013 14.8 0.1 2.3 2 0 0 2 2 2 1 Thi4 family FAD_binding_3 PF01494.19 EGD99881.1 - 0.0055 16.0 0.1 0.0091 15.3 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.7 EGD99881.1 - 0.021 14.2 0.5 0.032 13.6 0.5 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EGD99881.1 - 0.031 14.5 1.7 0.12 12.7 0.7 2.4 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain TCTP PF00838.17 EGD99882.1 - 7.7e-68 228.0 2.7 8.6e-68 227.9 2.7 1.0 1 0 0 1 1 1 1 Translationally controlled tumour protein LsmAD PF06741.13 EGD99882.1 - 0.058 13.9 1.8 0.13 12.8 0.3 2.0 2 0 0 2 2 2 0 LsmAD domain SRP19 PF01922.17 EGD99883.1 - 1.8e-32 112.1 0.0 3.9e-32 111.0 0.0 1.6 2 0 0 2 2 2 1 SRP19 protein Fungal_trans PF04082.18 EGD99884.1 - 2.7e-15 56.1 0.0 5.1e-15 55.2 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EGD99884.1 - 2.6e-10 40.2 8.6 5.1e-10 39.3 8.6 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain HNH_2 PF13391.6 EGD99885.1 - 4.6e-08 33.1 0.1 1.4e-07 31.5 0.1 1.9 1 0 0 1 1 1 1 HNH endonuclease BCS1_N PF08740.11 EGD99886.1 - 1e-49 169.0 0.5 2.1e-48 164.8 0.9 2.1 2 0 0 2 2 2 1 BCS1 N terminal AAA PF00004.29 EGD99886.1 - 2.4e-16 60.3 0.0 4.8e-08 33.5 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 EGD99886.1 - 0.0012 18.6 0.0 0.0021 17.8 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EGD99886.1 - 0.028 14.8 0.1 0.077 13.4 0.1 1.8 1 1 0 1 1 1 0 AAA ATPase domain AAA_18 PF13238.6 EGD99886.1 - 0.051 14.1 0.0 0.23 12.0 0.0 2.1 2 0 0 2 2 2 0 AAA domain Polyoma_lg_T_C PF06431.11 EGD99886.1 - 0.069 12.0 0.0 0.11 11.4 0.0 1.2 1 0 0 1 1 1 0 Polyomavirus large T antigen C-terminus ATPase PF06745.13 EGD99886.1 - 0.082 12.2 0.0 0.14 11.5 0.0 1.2 1 0 0 1 1 1 0 KaiC FA_hydroxylase PF04116.13 EGD99888.1 - 1.5e-22 80.3 16.8 1.6e-22 80.3 13.3 2.1 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily UNC-79 PF14776.6 EGD99888.1 - 0.034 12.9 0.0 0.047 12.4 0.0 1.1 1 0 0 1 1 1 0 Cation-channel complex subunit UNC-79 Aldo_ket_red PF00248.21 EGD99889.1 - 3.4e-57 193.9 0.0 3.8e-57 193.7 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Kelch_5 PF13854.6 EGD99890.1 - 3e-10 39.9 4.3 6.3e-10 38.8 0.4 3.1 3 0 0 3 3 3 1 Kelch motif Kelch_4 PF13418.6 EGD99890.1 - 2.4e-05 24.2 1.8 0.002 18.1 0.1 4.0 2 2 1 3 3 3 1 Galactose oxidase, central domain Kelch_1 PF01344.25 EGD99890.1 - 3.5e-05 23.3 2.7 0.1 12.2 0.3 4.1 3 1 0 3 3 3 2 Kelch motif Kelch_3 PF13415.6 EGD99890.1 - 0.0016 18.7 0.1 0.0016 18.7 0.1 3.6 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_6 PF13964.6 EGD99890.1 - 0.008 16.4 5.9 0.021 15.1 0.2 4.0 4 1 0 4 4 4 1 Kelch motif Kelch_2 PF07646.15 EGD99890.1 - 0.026 14.5 0.2 9.3 6.4 0.1 4.0 4 0 0 4 4 4 0 Kelch motif Pyr_redox_3 PF13738.6 EGD99897.1 - 0.00033 20.0 0.0 0.00054 19.3 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EGD99897.1 - 0.13 11.3 0.0 0.93 8.6 0.0 2.1 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) Pkinase PF00069.25 EGD99898.1 - 2.1e-16 60.1 0.0 1.5e-08 34.3 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EGD99898.1 - 6.2e-06 25.7 0.0 0.093 12.0 0.0 2.5 3 0 0 3 3 3 2 Protein tyrosine kinase APH PF01636.23 EGD99898.1 - 0.019 14.9 0.2 0.057 13.3 0.0 1.8 2 0 0 2 2 2 0 Phosphotransferase enzyme family DUF3700 PF12481.8 EGD99899.1 - 0.00032 20.2 0.5 0.27 10.7 0.0 2.1 2 0 0 2 2 2 2 Aluminium induced protein Arf PF00025.21 EGD99900.1 - 7.8e-39 132.9 0.0 3.2e-25 88.6 0.0 2.2 2 0 0 2 2 2 2 ADP-ribosylation factor family Roc PF08477.13 EGD99900.1 - 1.3e-12 48.0 0.0 3.8e-12 46.5 0.0 1.7 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 EGD99900.1 - 1.3e-11 44.3 0.0 7.6e-05 22.0 0.0 2.8 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.22 EGD99900.1 - 5.7e-08 32.5 0.0 0.00029 20.5 0.0 2.2 2 0 0 2 2 2 2 Ras family MMR_HSR1 PF01926.23 EGD99900.1 - 8.6e-08 32.3 0.0 8.7e-07 29.0 0.0 2.0 2 0 0 2 2 2 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EGD99900.1 - 4e-07 29.6 0.0 4.5e-07 29.5 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 EGD99900.1 - 4.9e-06 26.1 0.0 2.7e-05 23.7 0.0 1.9 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 EGD99900.1 - 7.2e-06 25.7 0.0 0.00025 20.6 0.0 2.3 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 EGD99900.1 - 0.015 14.8 0.0 0.035 13.6 0.0 1.6 2 0 0 2 2 2 0 Ferrous iron transport protein B PduV-EutP PF10662.9 EGD99900.1 - 0.022 14.5 0.0 0.063 13.0 0.1 1.7 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation TniB PF05621.11 EGD99900.1 - 0.031 13.7 0.0 0.053 12.9 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein DUF4630 PF15443.6 EGD99900.1 - 0.075 13.2 0.0 0.13 12.4 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4630) PIGA PF08288.12 EGD99901.1 - 8.8e-46 154.4 1.5 8.8e-46 154.4 1.5 1.7 2 0 0 2 2 2 1 PIGA (GPI anchor biosynthesis) Glyco_transf_4 PF13439.6 EGD99901.1 - 1.7e-27 96.5 0.3 2.7e-27 95.8 0.3 1.3 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glycos_transf_1 PF00534.20 EGD99901.1 - 5.5e-26 91.1 0.0 8.4e-26 90.5 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 EGD99901.1 - 3.8e-23 82.4 0.1 6.9e-23 81.6 0.1 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 EGD99901.1 - 2.3e-11 44.4 0.0 3.7e-11 43.7 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_trans_4_2 PF13477.6 EGD99901.1 - 6e-06 26.3 0.1 1.3e-05 25.3 0.1 1.5 1 0 0 1 1 1 1 Glycosyl transferase 4-like Glyco_trans_1_2 PF13524.6 EGD99901.1 - 0.00099 19.5 0.0 0.0039 17.6 0.0 2.0 2 0 0 2 2 2 1 Glycosyl transferases group 1 DEAD PF00270.29 EGD99902.1 - 6.9e-36 123.6 0.0 1.2e-17 64.2 0.0 2.8 2 1 1 3 3 3 2 DEAD/DEAH box helicase Helicase_C PF00271.31 EGD99902.1 - 1.8e-19 70.1 0.0 1.8e-18 66.9 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EGD99902.1 - 3.1e-07 30.5 0.0 1.8e-06 28.0 0.0 2.4 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 EGD99902.1 - 0.024 14.9 1.7 13 6.0 0.0 3.3 2 1 1 3 3 3 0 AAA domain Macoilin PF09726.9 EGD99902.1 - 2.9 6.3 21.7 0.011 14.4 2.6 2.1 2 0 0 2 2 2 0 Macoilin family Prp18 PF02840.15 EGD99903.1 - 8.3e-56 188.0 0.0 8.3e-56 188.0 0.0 2.0 2 1 0 2 2 2 1 Prp18 domain PRP4 PF08799.11 EGD99903.1 - 4.1e-12 45.4 2.5 4.1e-12 45.4 2.5 3.0 3 0 0 3 3 3 1 pre-mRNA processing factor 4 (PRP4) like CDC27 PF09507.10 EGD99903.1 - 0.88 8.9 23.4 1.5 8.1 23.4 1.3 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 MAJIN PF15077.6 EGD99903.1 - 6.7 6.4 10.8 11 5.7 10.8 1.4 1 0 0 1 1 1 0 Membrane-anchored junction protein SAP18 PF06487.12 EGD99904.1 - 3e-50 170.0 0.0 3.7e-50 169.7 0.0 1.1 1 0 0 1 1 1 1 Sin3 associated polypeptide p18 (SAP18) NDUF_B4 PF07225.12 EGD99905.1 - 7.9e-05 22.6 0.0 8.6e-05 22.4 0.0 1.1 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B15 subunit (NDUFB4) Methyltr_RsmB-F PF01189.17 EGD99906.1 - 3.4e-18 66.0 0.0 1.3e-10 41.2 0.0 2.5 2 0 0 2 2 2 2 16S rRNA methyltransferase RsmB/F Acetyltransf_1 PF00583.25 EGD99907.1 - 6.5e-11 42.5 0.0 8.9e-11 42.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EGD99907.1 - 5.7e-10 39.5 0.0 9e-10 38.8 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EGD99907.1 - 6.8e-10 39.0 0.0 9.6e-10 38.5 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_5 PF13444.6 EGD99907.1 - 1.4e-07 32.1 0.0 1.9e-06 28.5 0.0 2.1 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 EGD99907.1 - 3.7e-05 24.4 0.0 4.7e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 EGD99907.1 - 4.7e-05 23.4 0.0 8.4e-05 22.6 0.0 1.4 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase FR47 PF08445.10 EGD99907.1 - 0.00011 22.1 0.0 0.00031 20.6 0.0 1.7 1 1 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.7 EGD99907.1 - 0.00059 19.9 0.1 0.00093 19.3 0.1 1.6 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_15 PF17013.5 EGD99907.1 - 0.025 14.1 0.0 0.03 13.8 0.0 1.2 1 0 0 1 1 1 0 Putative acetyl-transferase FYVE PF01363.21 EGD99908.1 - 2.1e-14 53.4 5.5 3.1e-14 52.8 5.5 1.3 1 0 0 1 1 1 1 FYVE zinc finger zf-AN1 PF01428.16 EGD99908.1 - 0.063 13.4 9.3 0.14 12.4 9.3 1.5 1 0 0 1 1 1 0 AN1-like Zinc finger BTB_2 PF02214.22 EGD99909.1 - 6.4e-09 36.1 0.1 2.2e-05 24.7 0.0 2.7 3 0 0 3 3 3 2 BTB/POZ domain BTB PF00651.31 EGD99909.1 - 0.012 15.9 0.0 0.072 13.3 0.0 2.1 2 0 0 2 2 2 0 BTB/POZ domain GST_N PF02798.20 EGD99910.1 - 7.5e-12 45.4 0.0 1.2e-11 44.7 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 EGD99910.1 - 3.1e-09 37.1 0.1 1.2e-08 35.2 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EGD99910.1 - 6e-07 29.7 0.0 1e-06 29.0 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EGD99910.1 - 1.6e-05 25.0 0.0 2.7e-05 24.3 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EGD99910.1 - 0.0016 18.6 0.0 0.0025 18.0 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EGD99910.1 - 0.0074 16.3 0.0 0.013 15.5 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_5 PF16865.5 EGD99910.1 - 0.13 12.8 0.0 0.23 12.0 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Ank_2 PF12796.7 EGD99911.1 - 0.00089 19.8 0.1 0.0019 18.7 0.1 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EGD99911.1 - 0.0023 18.2 0.0 0.0061 16.9 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 EGD99911.1 - 0.0084 16.7 0.1 0.026 15.1 0.0 1.9 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Condensation PF00668.20 EGD99913.1 - 5.1e-245 813.3 0.1 1.4e-94 317.3 0.4 4.7 5 0 0 5 5 5 4 Condensation domain AMP-binding PF00501.28 EGD99913.1 - 9.6e-238 788.8 0.0 7.9e-88 294.9 0.0 4.3 3 1 1 4 4 4 4 AMP-binding enzyme PP-binding PF00550.25 EGD99913.1 - 1.8e-52 175.6 0.7 3.2e-17 62.6 0.1 4.0 3 0 0 3 3 3 3 Phosphopantetheine attachment site AMP-binding_C PF13193.6 EGD99913.1 - 4e-25 88.6 0.0 7.2e-10 39.7 0.0 3.7 3 0 0 3 3 3 3 AMP-binding enzyme C-terminal domain Thioesterase PF00975.20 EGD99913.1 - 6.1e-25 88.7 0.0 1.3e-24 87.7 0.0 1.5 1 0 0 1 1 1 1 Thioesterase domain Abhydrolase_6 PF12697.7 EGD99913.1 - 0.0011 19.7 0.1 0.0046 17.6 0.0 2.1 2 0 0 2 2 2 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EGD99913.1 - 0.02 14.1 0.0 0.26 10.5 0.0 2.3 2 0 0 2 2 2 0 Serine aminopeptidase, S33 AATase PF07247.12 EGD99913.1 - 0.022 13.3 0.0 0.083 11.4 0.0 1.9 1 0 0 1 1 1 0 Alcohol acetyltransferase 2OG-FeII_Oxy PF03171.20 EGD99914.1 - 1.1e-13 51.5 0.1 3.3e-13 50.0 0.0 1.8 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.6 EGD99914.1 - 3.1e-13 50.5 0.0 4.6e-13 50.0 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal AAT PF03417.16 EGD99915.1 - 3.5e-38 131.6 0.0 4.3e-38 131.3 0.0 1.1 1 0 0 1 1 1 1 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase Peptidase_S8 PF00082.22 EGD99916.1 - 2.2e-33 115.8 15.0 6.7e-33 114.2 15.0 1.6 1 1 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 EGD99916.1 - 1.2e-16 61.1 0.1 7.3e-16 58.6 0.0 2.1 2 0 0 2 2 2 1 Peptidase inhibitor I9 Kdo PF06293.14 EGD99918.1 - 1.2e-07 31.3 0.1 2.5e-07 30.2 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EGD99918.1 - 0.02 14.8 0.1 0.02 14.8 0.1 2.7 2 1 0 2 2 2 0 Phosphotransferase enzyme family Pkinase PF00069.25 EGD99918.1 - 0.12 11.7 0.0 0.32 10.3 0.0 1.6 1 0 0 1 1 1 0 Protein kinase domain DUF874 PF05917.11 EGD99918.1 - 0.74 8.8 6.9 1.2 8.1 6.9 1.2 1 0 0 1 1 1 0 Helicobacter pylori protein of unknown function (DUF874) Casc1_N PF15927.5 EGD99918.1 - 3.5 7.3 18.7 9.1 5.9 18.7 1.7 1 0 0 1 1 1 0 Cancer susceptibility candidate 1 N-terminus CiPC PF15800.5 EGD99918.1 - 6.7 6.3 13.4 11 5.6 3.0 3.1 3 0 0 3 3 3 0 Clock interacting protein circadian Neur_chan_memb PF02932.16 EGD99918.1 - 8.3 6.4 5.8 9.4 6.2 0.0 2.3 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Peptidase_S41 PF03572.18 EGD99919.1 - 8.9e-08 31.9 0.0 2.4e-07 30.5 0.0 1.7 1 1 0 1 1 1 1 Peptidase family S41 DUF1659 PF07872.11 EGD99919.1 - 0.033 13.9 0.1 0.065 12.9 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1659) Flg_bb_rod PF00460.20 EGD99920.1 - 0.027 14.4 0.0 0.064 13.2 0.0 1.7 1 0 0 1 1 1 0 Flagella basal body rod protein Transferase PF02458.15 EGD99921.1 - 2.2e-16 59.6 0.0 2.5e-11 42.9 0.0 3.1 3 0 0 3 3 3 3 Transferase family TAF4 PF05236.14 EGD99924.1 - 5.8e-26 91.9 5.2 6.1e-25 88.5 5.2 2.4 1 1 0 1 1 1 1 Transcription initiation factor TFIID component TAF4 family CPSF73-100_C PF11718.8 EGD99925.1 - 1.6e-79 266.4 0.0 2.7e-79 265.7 0.0 1.4 1 0 0 1 1 1 1 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term Beta-Casp PF10996.8 EGD99925.1 - 3.6e-31 107.7 0.0 1e-30 106.3 0.0 1.8 1 0 0 1 1 1 1 Beta-Casp domain Lactamase_B PF00753.27 EGD99925.1 - 2.1e-22 80.1 0.1 4.6e-22 79.0 0.1 1.6 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_6 PF16661.5 EGD99925.1 - 1.8e-16 60.1 0.1 3e-16 59.4 0.1 1.3 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain RMMBL PF07521.12 EGD99925.1 - 5e-12 45.6 0.4 1.3e-11 44.2 0.1 1.9 2 0 0 2 2 2 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B_2 PF12706.7 EGD99925.1 - 9.8e-05 22.0 0.1 0.0002 21.0 0.1 1.5 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 EGD99925.1 - 0.0002 21.3 0.0 0.00098 19.1 0.0 2.0 1 1 0 1 1 1 1 Beta-lactamase superfamily domain FAD_binding_4 PF01565.23 EGD99926.1 - 1.6e-22 79.8 0.6 3e-22 78.8 0.6 1.5 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EGD99926.1 - 1.4e-12 47.5 0.4 3.2e-12 46.4 0.1 1.8 2 0 0 2 2 2 1 Berberine and berberine like DPBB_1 PF03330.18 EGD99927.1 - 0.0015 18.7 0.4 0.0029 17.8 0.4 1.6 1 1 0 1 1 1 1 Lytic transglycolase Barwin PF00967.17 EGD99927.1 - 0.014 15.3 0.0 0.022 14.6 0.0 1.3 1 0 0 1 1 1 0 Barwin family Pkinase PF00069.25 EGD99928.1 - 2.3e-49 168.1 0.0 1.3e-48 165.7 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGD99928.1 - 1.4e-19 70.4 0.0 5e-19 68.6 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase Mtc PF03820.17 EGD99930.1 - 5e-118 393.7 0.0 5.7e-118 393.5 0.0 1.0 1 0 0 1 1 1 1 Tricarboxylate carrier PHD PF00628.29 EGD99931.1 - 5.5e-08 32.6 7.3 1e-07 31.7 7.3 1.5 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 EGD99931.1 - 0.77 9.4 6.0 1.4 8.5 6.0 1.4 1 0 0 1 1 1 0 PHD-finger NUP50 PF08911.11 EGD99931.1 - 3.3 8.4 8.0 0.35 11.6 1.9 2.6 2 0 0 2 2 2 0 NUP50 (Nucleoporin 50 kDa) BNIP2 PF12496.8 EGD99931.1 - 3.4 8.1 6.3 1 9.8 0.2 2.8 3 0 0 3 3 3 0 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 TFIIF_alpha PF05793.12 EGD99931.1 - 8.5 4.8 8.8 0.14 10.8 1.3 1.7 2 0 0 2 2 2 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) DUF2293 PF10056.9 EGD99932.1 - 1.4e-23 82.9 0.9 2.6e-23 82.0 0.9 1.4 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2293) RPE65 PF03055.15 EGD99933.1 - 1.9e-113 380.2 0.0 2.1e-113 380.0 0.0 1.0 1 0 0 1 1 1 1 Retinal pigment epithelial membrane protein P53_TAD PF08563.11 EGD99934.1 - 0.055 13.0 0.2 0.12 11.9 0.2 1.6 1 0 0 1 1 1 0 P53 transactivation motif Acetyltransf_10 PF13673.7 EGD99935.1 - 0.00035 20.5 0.0 0.00069 19.6 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EGD99935.1 - 0.015 15.6 0.0 0.024 14.8 0.0 1.4 1 1 0 1 1 1 0 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EGD99935.1 - 0.017 15.5 0.0 0.031 14.7 0.0 1.6 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Cupin_1 PF00190.22 EGD99936.1 - 3.7e-36 124.0 0.0 4.5e-18 65.3 0.0 2.2 2 0 0 2 2 2 2 Cupin Cupin_2 PF07883.11 EGD99936.1 - 1.6e-19 69.4 1.6 1.1e-08 34.7 0.1 2.4 2 0 0 2 2 2 2 Cupin domain AraC_binding PF02311.19 EGD99936.1 - 9.3e-05 22.3 1.2 0.035 14.0 0.2 2.3 2 0 0 2 2 2 2 AraC-like ligand binding domain Cupin_3 PF05899.12 EGD99936.1 - 9.6e-05 22.0 0.2 0.15 11.7 0.0 2.6 2 0 0 2 2 2 2 Protein of unknown function (DUF861) 3-HAO PF06052.12 EGD99936.1 - 0.029 14.0 0.0 0.3 10.7 0.0 2.1 2 0 0 2 2 2 0 3-hydroxyanthranilic acid dioxygenase Cupin_4 PF08007.12 EGD99936.1 - 0.17 11.3 0.0 0.28 10.6 0.0 1.2 1 0 0 1 1 1 0 Cupin superfamily protein TruD PF01142.18 EGD99937.1 - 1.8e-61 208.2 0.0 2.7e-58 197.8 0.0 2.6 2 1 0 2 2 2 2 tRNA pseudouridine synthase D (TruD) BNR PF02012.20 EGD99938.1 - 0.042 13.8 1.2 0.089 12.8 0.2 2.2 2 0 0 2 2 2 0 BNR/Asp-box repeat APH PF01636.23 EGD99939.1 - 3.5e-13 50.0 2.1 1.8e-12 47.7 0.3 2.5 2 1 0 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EGD99939.1 - 5.7e-05 22.8 0.0 0.00014 21.5 0.0 1.7 1 0 0 1 1 1 1 Choline/ethanolamine kinase Neurensin PF14927.6 EGD99941.1 - 0.022 14.5 0.4 0.036 13.8 0.4 1.4 1 0 0 1 1 1 0 Neurensin CBS PF00571.28 EGD99943.1 - 1.7e-06 28.3 0.2 0.036 14.5 0.0 2.6 3 0 0 3 3 3 2 CBS domain P5CR_dimer PF14748.6 EGD99944.1 - 1.8e-31 108.4 3.3 2.9e-31 107.8 3.3 1.3 1 0 0 1 1 1 1 Pyrroline-5-carboxylate reductase dimerisation F420_oxidored PF03807.17 EGD99944.1 - 2.6e-10 40.8 0.0 9.9e-08 32.5 0.0 2.9 3 0 0 3 3 3 2 NADP oxidoreductase coenzyme F420-dependent CTK3 PF12243.8 EGD99945.1 - 4.8e-49 165.5 0.1 6.7e-49 165.0 0.1 1.2 1 0 0 1 1 1 1 CTD kinase subunit gamma CTK3 CTK3_C PF12350.8 EGD99945.1 - 1.1e-20 73.5 12.7 1.3e-20 73.3 11.2 1.9 2 0 0 2 2 2 1 CTD kinase subunit gamma CTK3 C-terminus DUF4240 PF14024.6 EGD99945.1 - 0.03 14.5 0.5 0.95 9.7 0.4 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF4240) DUF4194 PF13835.6 EGD99945.1 - 0.074 12.8 0.7 5 6.8 0.4 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4194) CARD PF00619.21 EGD99945.1 - 0.099 12.7 0.3 0.4 10.8 0.1 2.1 2 1 0 3 3 3 0 Caspase recruitment domain U3_snoRNA_assoc PF08297.11 EGD99946.1 - 3.3e-11 43.8 0.5 3.3e-11 43.8 0.5 4.8 3 3 0 3 3 3 1 U3 snoRNA associated Borrelia_P83 PF05262.11 EGD99946.1 - 0.081 11.4 16.4 0.13 10.8 16.4 1.4 1 0 0 1 1 1 0 Borrelia P83/100 protein HNH_2 PF13391.6 EGD99947.1 - 4.5e-11 42.7 0.0 1.1e-10 41.5 0.0 1.7 1 1 0 1 1 1 1 HNH endonuclease GTP1_OBG PF01018.22 EGD99948.1 - 0.14 11.8 1.7 0.23 11.0 1.7 1.3 1 0 0 1 1 1 0 GTP1/OBG DUF155 PF02582.14 EGD99950.1 - 1.6e-51 174.9 0.2 2.3e-51 174.4 0.2 1.3 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 Trypsin_2 PF13365.6 EGD99952.1 - 7.2e-06 27.0 0.3 0.00011 23.1 0.2 2.6 1 1 1 2 2 2 1 Trypsin-like peptidase domain Peptidase_S64 PF08192.11 EGD99952.1 - 0.00061 18.4 0.1 0.012 14.1 0.1 2.1 2 0 0 2 2 2 1 Peptidase family S64 Peptidase_S32 PF05579.13 EGD99952.1 - 0.041 13.1 0.0 0.077 12.2 0.0 1.3 1 0 0 1 1 1 0 Equine arteritis virus serine endopeptidase S32 Peptidase_S7 PF00949.21 EGD99952.1 - 0.075 12.9 0.0 0.17 11.7 0.0 1.5 1 0 0 1 1 1 0 Peptidase S7, Flavivirus NS3 serine protease Peptidase_S46 PF10459.9 EGD99952.1 - 0.17 10.5 0.0 0.26 9.9 0.0 1.2 1 0 0 1 1 1 0 Peptidase S46 p450 PF00067.22 EGD99954.1 - 2.8e-68 230.8 0.0 3.3e-68 230.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Ca_chan_IQ PF08763.11 EGD99954.1 - 0.0028 17.8 0.0 0.011 16.0 0.0 1.9 2 0 0 2 2 2 1 Voltage gated calcium channel IQ domain p450 PF00067.22 EGD99955.1 - 6.3e-57 193.3 0.0 8e-57 193.0 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 adh_short PF00106.25 EGD99957.1 - 3.7e-28 98.3 0.0 3.4e-26 91.9 0.0 2.1 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EGD99957.1 - 2.4e-16 60.0 0.0 3.5e-15 56.2 0.0 2.0 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EGD99957.1 - 5.3e-06 26.5 0.0 8.2e-06 25.8 0.0 1.3 1 0 0 1 1 1 1 KR domain Shikimate_DH PF01488.20 EGD99957.1 - 0.007 16.4 0.0 0.012 15.7 0.0 1.3 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Epimerase PF01370.21 EGD99957.1 - 0.01 15.3 0.0 0.012 15.0 0.0 1.3 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Csm1_B PF18211.1 EGD99957.1 - 0.065 13.1 0.0 0.15 11.9 0.0 1.6 1 0 0 1 1 1 0 Csm1 subunit domain B GDP_Man_Dehyd PF16363.5 EGD99957.1 - 0.15 11.4 0.0 0.2 11.0 0.0 1.1 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Sacchrp_dh_NADP PF03435.18 EGD99957.1 - 0.18 12.0 0.0 0.34 11.2 0.0 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain RVT_1 PF00078.27 EGD99960.1 - 1.2e-32 113.2 0.0 2.2e-32 112.4 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 EGD99960.1 - 3.8e-28 97.7 0.1 5.8e-27 93.9 0.0 2.6 2 0 0 2 2 2 1 Endonuclease-reverse transcriptase RNase_H PF00075.24 EGD99960.1 - 9.6e-07 29.1 0.7 1.1e-05 25.7 0.1 2.9 2 1 0 2 2 2 1 RNase H Exo_endo_phos PF03372.23 EGD99960.1 - 0.0024 17.5 0.3 0.0076 15.8 0.3 1.8 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family zf-CCHC_3 PF13917.6 EGD99960.1 - 0.0068 16.3 0.6 0.021 14.8 0.6 1.8 1 0 0 1 1 1 1 Zinc knuckle DivIC PF04977.15 EGD99960.1 - 0.024 14.4 0.8 0.094 12.5 0.8 2.1 1 0 0 1 1 1 0 Septum formation initiator HALZ PF02183.18 EGD99960.1 - 0.032 14.4 1.6 0.076 13.2 1.6 1.6 1 0 0 1 1 1 0 Homeobox associated leucine zipper ZapB PF06005.12 EGD99960.1 - 0.057 13.9 0.3 0.057 13.9 0.3 2.8 2 0 0 2 2 2 0 Cell division protein ZapB Mito_fiss_reg PF05308.11 EGD99960.1 - 0.082 13.0 2.9 0.14 12.2 0.5 2.4 2 0 0 2 2 2 0 Mitochondrial fission regulator IGR PF09597.10 EGD99960.1 - 0.11 12.6 0.1 0.73 10.0 0.0 2.5 2 0 0 2 2 2 0 IGR protein motif DUF1664 PF07889.12 EGD99960.1 - 0.13 12.3 2.5 0.39 10.7 1.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) DUF3294 PF07957.11 EGD99960.1 - 0.22 11.3 1.2 0.4 10.4 1.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3294) Tup_N PF08581.10 EGD99960.1 - 0.24 11.7 1.7 0.59 10.5 1.7 1.6 1 0 0 1 1 1 0 Tup N-terminal bZIP_1 PF00170.21 EGD99960.1 - 2.9 8.0 6.7 0.18 11.9 0.6 2.3 2 0 0 2 2 1 0 bZIP transcription factor Seryl_tRNA_N PF02403.22 EGD99960.1 - 5.2 7.3 6.3 22 5.3 0.6 3.1 3 0 0 3 3 3 0 Seryl-tRNA synthetase N-terminal domain Pkinase_fungal PF17667.1 EGD99961.1 - 1.8e-125 419.0 0.0 2.2e-125 418.6 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Pkinase PF00069.25 EGD99961.1 - 0.0017 17.8 0.0 0.0028 17.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain zf-C2H2 PF00096.26 EGD99962.1 - 0.0016 18.8 0.1 0.0036 17.7 0.1 1.6 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EGD99962.1 - 0.0037 18.0 0.2 0.0099 16.6 0.2 1.8 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2_2 PF12756.7 EGD99962.1 - 0.072 13.4 0.7 0.12 12.8 0.7 1.4 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) SesA PF17107.5 EGD99964.1 - 1.2e-32 112.7 0.4 4.4e-18 65.6 0.0 2.3 1 1 1 2 2 2 2 N-terminal domain on NACHT_NTPase and P-loop NTPases HeLo PF14479.6 EGD99964.1 - 0.00058 19.8 0.1 0.0022 17.9 0.1 1.8 1 1 0 1 1 1 1 Prion-inhibition and propagation NACHT_sigma PF17106.5 EGD99964.1 - 0.0036 17.4 23.1 0.23 11.6 23.1 2.2 1 1 0 1 1 1 1 Sigma domain on NACHT-NTPases DUF2802 PF10975.8 EGD99964.1 - 0.015 15.4 0.0 0.054 13.6 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2802) HNF-1_N PF04814.13 EGD99964.1 - 0.075 13.6 0.1 0.14 12.7 0.1 1.5 1 0 0 1 1 1 0 Hepatocyte nuclear factor 1 (HNF-1), N terminus NB-ARC PF00931.22 EGD99965.1 - 6.7e-07 28.8 0.0 2.2e-06 27.1 0.0 1.9 2 1 0 2 2 2 1 NB-ARC domain TPR_10 PF13374.6 EGD99965.1 - 0.015 15.2 0.0 0.04 13.8 0.0 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_12 PF13424.6 EGD99965.1 - 0.031 14.6 0.1 0.25 11.7 0.0 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat AAA_16 PF13191.6 EGD99965.1 - 0.034 14.5 0.8 1.4 9.3 0.0 2.8 2 1 1 3 3 3 0 AAA ATPase domain NTPase_1 PF03266.15 EGD99965.1 - 0.035 14.0 0.0 0.068 13.1 0.0 1.5 1 0 0 1 1 1 0 NTPase WH1 PF00568.23 EGD99965.1 - 0.11 12.4 0.0 0.27 11.2 0.0 1.6 1 0 0 1 1 1 0 WH1 domain Dala_Dala_lig_C PF07478.13 EGD99966.1 - 0.12 11.9 0.0 0.17 11.4 0.0 1.2 1 0 0 1 1 1 0 D-ala D-ala ligase C-terminus CPT_N PF16484.5 EGD99972.1 - 0.03 14.3 0.0 0.054 13.5 0.0 1.3 1 0 0 1 1 1 0 Carnitine O-palmitoyltransferase N-terminus Phage_holin_2_1 PF04971.12 EGD99973.1 - 0.14 12.1 0.1 1 9.4 0.0 2.1 2 0 0 2 2 2 0 Bacteriophage P21 holin S Phage_holin_2_3 PF16080.5 EGD99973.1 - 0.22 11.3 1.4 2.8 7.7 1.1 2.3 2 0 0 2 2 2 0 Bacteriophage holin family HP1 CtIP_N PF10482.9 EGD99974.1 - 0.011 15.7 2.3 0.021 14.9 2.3 1.4 1 0 0 1 1 1 0 Tumour-suppressor protein CtIP N-terminal domain DUF2408 PF10303.9 EGD99974.1 - 0.11 13.1 0.7 0.2 12.2 0.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2408) Hat1_N PF10394.9 EGD99975.1 - 3.4e-56 189.9 0.1 7.2e-56 188.9 0.1 1.6 1 0 0 1 1 1 1 Histone acetyl transferase HAT1 N-terminus DUF917 PF06032.12 EGD99976.1 - 6.9e-103 344.1 0.2 1.6e-101 339.6 0.0 2.6 2 1 1 3 3 3 1 Protein of unknown function (DUF917) Hydant_A_N PF05378.13 EGD99976.1 - 9.7e-29 100.3 7.5 1.8e-26 92.9 0.0 4.2 4 0 0 4 4 4 2 Hydantoinase/oxoprolinase N-terminal region Hydantoinase_A PF01968.18 EGD99976.1 - 1.1e-25 90.5 11.3 1.5e-23 83.5 3.0 3.4 2 1 1 3 3 3 3 Hydantoinase/oxoprolinase BcrAD_BadFG PF01869.20 EGD99976.1 - 0.0018 17.8 0.6 0.0018 17.8 0.6 2.2 3 0 0 3 3 3 1 BadF/BadG/BcrA/BcrD ATPase family DUF3663 PF12404.8 EGD99976.1 - 0.17 12.0 0.0 0.54 10.3 0.0 1.8 1 0 0 1 1 1 0 Peptidase StbA PF06406.11 EGD99976.1 - 0.6 9.3 2.4 5 6.3 0.2 2.4 1 1 0 2 2 2 0 StbA protein Transp_cyt_pur PF02133.15 EGD99977.1 - 3.2e-94 316.2 39.1 3.1e-93 313.0 39.1 1.9 1 1 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Zip PF02535.22 EGD99978.1 - 4.7e-39 134.5 21.5 3.3e-31 108.7 15.4 3.4 2 1 0 2 2 2 2 ZIP Zinc transporter WD40 PF00400.32 EGD99979.1 - 9.7e-37 124.4 21.6 1.1e-06 29.2 0.1 7.4 7 0 0 7 7 7 6 WD domain, G-beta repeat F-box-like PF12937.7 EGD99979.1 - 1.7e-10 40.6 0.6 3.3e-10 39.7 0.6 1.5 1 0 0 1 1 1 1 F-box-like ANAPC4_WD40 PF12894.7 EGD99979.1 - 7.4e-10 39.0 0.8 0.11 12.8 0.0 5.8 1 1 4 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EGD99979.1 - 6.9e-07 28.3 4.8 0.066 11.9 0.1 5.1 2 2 3 6 6 6 3 Nucleoporin Nup120/160 WD40_like PF17005.5 EGD99979.1 - 1.4e-05 24.6 0.0 0.0026 17.1 0.0 3.0 1 1 1 3 3 3 1 WD40-like domain F-box PF00646.33 EGD99979.1 - 0.00068 19.5 0.6 0.0016 18.3 0.6 1.7 1 0 0 1 1 1 1 F-box domain PQQ_2 PF13360.6 EGD99979.1 - 0.0076 15.9 1.3 0.025 14.2 0.5 2.2 1 1 1 2 2 2 1 PQQ-like domain F-box_5 PF18511.1 EGD99979.1 - 0.055 13.0 0.0 0.11 12.1 0.0 1.5 1 0 0 1 1 1 0 F-box Nudix_hydro PF18290.1 EGD99981.1 - 0.15 12.1 0.0 0.28 11.2 0.0 1.4 1 0 0 1 1 1 0 Nudix hydrolase domain Sugar_tr PF00083.24 EGD99982.1 - 1.3e-87 294.6 22.6 1.3e-87 294.6 22.6 1.5 1 1 1 2 2 2 1 Sugar (and other) transporter MFS_1 PF07690.16 EGD99982.1 - 1.7e-11 43.7 46.2 2.2e-07 30.1 14.8 2.2 1 1 0 2 2 2 2 Major Facilitator Superfamily Fungal_trans PF04082.18 EGD99983.1 - 1.4e-07 30.9 0.2 1.4e-07 30.9 0.2 2.1 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EGD99983.1 - 0.0013 18.8 12.7 0.0028 17.8 12.7 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Dickkopf_N PF04706.12 EGD99983.1 - 9.4 6.8 9.9 31 5.2 10.0 1.8 1 1 0 1 1 1 0 Dickkopf N-terminal cysteine-rich region RINGv PF12906.7 EGD99985.1 - 1.8e-09 37.5 2.4 1.5e-08 34.6 0.6 2.4 2 0 0 2 2 2 1 RING-variant domain PHD_4 PF16866.5 EGD99985.1 - 0.13 12.4 1.6 0.82 9.8 0.6 2.4 2 0 0 2 2 2 0 PHD-finger DUF1218 PF06749.12 EGD99985.1 - 0.29 11.7 0.3 0.29 11.7 0.3 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1218) zf-RING_2 PF13639.6 EGD99985.1 - 0.39 11.1 3.7 5.5 7.4 0.8 2.3 2 0 0 2 2 2 0 Ring finger domain PHD PF00628.29 EGD99985.1 - 1.8 8.5 6.2 0.5 10.3 2.8 1.8 2 0 0 2 2 2 0 PHD-finger Proteasome PF00227.26 EGD99986.1 - 7.5e-58 195.1 0.0 6.2e-33 113.9 0.0 2.2 1 1 1 2 2 2 2 Proteasome subunit Proteasome_A_N PF10584.9 EGD99986.1 - 9.2e-11 41.2 0.1 3.1e-10 39.5 0.0 1.9 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature Ribonuclease_3 PF00636.26 EGD99987.1 - 1.3e-40 138.3 0.0 9.7e-20 71.2 0.0 2.7 2 0 0 2 2 2 2 Ribonuclease III domain Dicer_dimer PF03368.14 EGD99987.1 - 1.8e-23 82.5 0.0 4.1e-23 81.4 0.0 1.6 1 0 0 1 1 1 1 Dicer dimerisation domain Ribonucleas_3_3 PF14622.6 EGD99987.1 - 2.8e-21 76.0 0.3 1.7e-12 47.6 0.0 3.7 3 0 0 3 3 3 2 Ribonuclease-III-like DEAD PF00270.29 EGD99987.1 - 6.4e-19 68.4 0.0 1.3e-18 67.4 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EGD99987.1 - 1.9e-14 54.0 0.0 6.2e-14 52.3 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EGD99987.1 - 8.1e-14 52.0 0.0 1.6e-13 51.0 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit dsrm PF00035.26 EGD99987.1 - 0.041 14.6 0.1 0.35 11.6 0.0 2.4 2 0 0 2 2 2 0 Double-stranded RNA binding motif zf-C2H2_jaz PF12171.8 EGD99991.1 - 0.0019 18.4 1.0 0.035 14.4 0.0 2.6 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-LYAR PF08790.11 EGD99991.1 - 0.021 14.7 0.7 3.8 7.5 0.1 2.6 2 0 0 2 2 2 0 LYAR-type C2HC zinc finger zf-C2H2 PF00096.26 EGD99991.1 - 0.073 13.6 3.0 0.83 10.2 0.0 3.4 3 0 0 3 3 3 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EGD99991.1 - 0.27 12.2 6.4 13 7.0 0.1 3.9 4 0 0 4 4 4 0 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EGD99991.1 - 3.3 8.3 7.3 1.8 9.1 0.3 3.2 3 0 0 3 3 3 0 Zinc-finger double domain 6PGD PF00393.19 EGD99992.1 - 4.8e-76 255.9 0.0 6.9e-76 255.4 0.0 1.1 1 0 0 1 1 1 1 6-phosphogluconate dehydrogenase, C-terminal domain NAD_binding_2 PF03446.15 EGD99992.1 - 1.5e-31 109.7 0.2 2.7e-31 108.9 0.2 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase 3HCDH_N PF02737.18 EGD99992.1 - 7.9e-07 29.1 0.1 1.5e-06 28.3 0.1 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_Gly3P_dh_N PF01210.23 EGD99992.1 - 0.00038 20.5 0.1 0.00069 19.6 0.1 1.4 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Shikimate_DH PF01488.20 EGD99992.1 - 0.0019 18.2 0.0 0.0051 16.9 0.0 1.7 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase UDPG_MGDP_dh_N PF03721.14 EGD99992.1 - 0.0038 16.8 0.3 0.019 14.6 0.1 2.0 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain F420_oxidored PF03807.17 EGD99992.1 - 0.0062 17.1 0.1 0.02 15.5 0.1 2.0 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent 2-Hacid_dh_C PF02826.19 EGD99992.1 - 0.033 13.5 1.0 0.044 13.1 0.1 1.6 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_8 PF13450.6 EGD99992.1 - 0.035 14.3 0.0 0.079 13.2 0.0 1.6 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain ApbA PF02558.16 EGD99992.1 - 0.046 13.4 0.0 0.081 12.6 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA RTA1 PF04479.13 EGD99993.1 - 5e-72 241.9 5.7 6.6e-72 241.4 5.7 1.2 1 0 0 1 1 1 1 RTA1 like protein DUF3098 PF11297.8 EGD99993.1 - 0.072 12.7 3.0 1.5 8.5 0.2 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3098) Zn_clus PF00172.18 EGD99994.1 - 2.5e-08 33.9 10.6 4.1e-08 33.2 10.6 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 EGD99994.1 - 6.1e-05 22.0 0.0 9.8e-05 21.3 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain EB PF01683.18 EGD99995.1 - 0.00047 20.4 4.4 0.00051 20.3 4.4 1.1 1 0 0 1 1 1 1 EB module LSM PF01423.22 EGD99996.1 - 8.5e-15 54.2 0.1 1.5e-14 53.4 0.1 1.4 1 0 0 1 1 1 1 LSM domain NUC173 PF08161.12 EGD99997.1 - 9e-79 263.9 0.9 6.5e-76 254.5 0.1 3.2 3 0 0 3 3 3 2 NUC173 domain RsbRD_N PF14361.6 EGD99997.1 - 0.024 15.3 0.1 0.82 10.4 0.0 3.7 3 0 0 3 3 3 0 RsbT co-antagonist protein rsbRD N-terminal domain CPSF100_C PF13299.6 EGD99997.1 - 0.33 11.1 4.5 0.46 10.6 1.9 2.5 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal SYF2 PF08231.12 EGD99997.1 - 0.73 10.2 7.7 1.8 9.0 7.7 1.6 1 0 0 1 1 1 0 SYF2 splicing factor CENP-B_dimeris PF09026.10 EGD99998.1 - 0.00017 21.9 22.3 0.00057 20.2 7.3 2.7 2 0 0 2 2 2 2 Centromere protein B dimerisation domain PBP1_TM PF14812.6 EGD99998.1 - 0.006 16.9 10.1 0.006 16.9 10.1 3.3 3 0 0 3 3 3 1 Transmembrane domain of transglycosylase PBP1 at N-terminal Afi1 PF07792.12 EGD99998.1 - 0.033 14.7 12.4 0.12 12.9 7.4 3.0 3 0 0 3 3 3 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Presenilin PF01080.17 EGD99998.1 - 0.046 12.5 3.6 0.1 11.3 0.1 2.2 2 0 0 2 2 2 0 Presenilin GEMIN8 PF15348.6 EGD99998.1 - 0.13 12.5 20.1 0.093 13.0 11.1 2.2 2 0 0 2 2 2 0 Gemini of Cajal bodies-associated protein 8 FAM60A PF15396.6 EGD99998.1 - 0.22 11.5 7.3 0.18 11.8 2.1 2.2 2 0 0 2 2 2 0 Protein Family FAM60A NOA36 PF06524.12 EGD99998.1 - 0.34 10.2 26.4 0.37 10.1 15.0 2.3 2 0 0 2 2 2 0 NOA36 protein DUF4834 PF16118.5 EGD99998.1 - 0.86 10.6 5.5 1.2e+02 3.7 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) FAM76 PF16046.5 EGD99998.1 - 5 6.4 9.8 1.7 7.9 0.2 2.1 2 0 0 2 2 2 0 FAM76 protein Radial_spoke PF04712.12 EGD99998.1 - 5.7 5.8 8.5 8.5 5.2 8.5 1.2 1 0 0 1 1 1 0 Radial spokehead-like protein DUF2615 PF11027.8 EGD99999.1 - 0.00051 20.1 0.5 0.00085 19.4 0.5 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2615) UCMA PF17085.5 EGD99999.1 - 0.0016 18.5 6.4 0.0019 18.2 6.4 1.1 1 0 0 1 1 1 1 Unique cartilage matrix associated protein FAM176 PF14851.6 EGD99999.1 - 0.0053 16.4 1.4 0.0069 16.1 1.4 1.1 1 0 0 1 1 1 1 FAM176 family DUF4834 PF16118.5 EGD99999.1 - 0.023 15.6 0.8 0.034 15.1 0.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Conotoxin PF02950.17 EGD99999.1 - 0.037 15.1 2.5 0.063 14.3 2.5 1.5 1 1 0 1 1 1 0 Conotoxin SID-1_RNA_chan PF13965.6 EGD99999.1 - 0.041 12.3 0.4 0.044 12.2 0.4 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Wzy_C_2 PF11846.8 EGD99999.1 - 0.066 13.1 0.0 0.081 12.8 0.0 1.2 1 0 0 1 1 1 0 Virulence factor membrane-bound polymerase, C-terminal CLN3 PF02487.17 EGD99999.1 - 0.12 11.4 0.0 0.13 11.3 0.0 1.0 1 0 0 1 1 1 0 CLN3 protein V_ATPase_I PF01496.19 EGD99999.1 - 0.24 9.3 2.4 0.27 9.1 2.4 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Connexin PF00029.19 EGD99999.1 - 0.3 10.8 2.5 0.37 10.5 2.5 1.1 1 0 0 1 1 1 0 Connexin TMEM89 PF15098.6 EGD99999.1 - 0.86 9.8 4.1 1.2 9.3 4.1 1.3 1 1 0 1 1 1 0 TMEM89 protein family EphA2_TM PF14575.6 EGD99999.1 - 2.2 9.2 4.2 4.7 8.2 4.2 1.7 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain GRP PF07172.11 EGD99999.1 - 3 8.6 5.0 0.41 11.3 0.5 2.0 2 1 0 2 2 2 0 Glycine rich protein family TPR_1 PF00515.28 EGE00001.1 - 2.1e-49 163.4 31.1 7.9e-08 31.8 0.1 11.3 10 2 0 10 10 10 9 Tetratricopeptide repeat TPR_2 PF07719.17 EGE00001.1 - 6e-45 147.8 22.5 9.1e-06 25.4 0.0 11.2 10 1 0 10 10 10 9 Tetratricopeptide repeat TPR_8 PF13181.6 EGE00001.1 - 1.3e-36 121.7 18.8 6.9e-07 29.0 0.0 10.8 10 1 0 10 10 10 7 Tetratricopeptide repeat TPR_17 PF13431.6 EGE00001.1 - 2.2e-21 74.6 32.0 0.00014 22.0 0.2 10.3 11 0 0 11 11 10 5 Tetratricopeptide repeat TPR_16 PF13432.6 EGE00001.1 - 2.8e-20 72.7 32.1 1.9e-05 25.2 0.0 7.1 7 1 0 8 8 6 5 Tetratricopeptide repeat TPR_11 PF13414.6 EGE00001.1 - 1.1e-19 69.8 29.1 6e-05 22.6 1.5 9.0 5 2 4 9 9 9 6 TPR repeat TPR_19 PF14559.6 EGE00001.1 - 6.6e-18 65.0 35.1 2.5e-05 24.7 0.5 7.6 6 2 1 7 7 6 5 Tetratricopeptide repeat TPR_6 PF13174.6 EGE00001.1 - 6.7e-17 60.9 32.1 0.0039 17.7 0.0 10.8 11 0 0 11 11 10 5 Tetratricopeptide repeat TPR_14 PF13428.6 EGE00001.1 - 9.1e-17 60.3 37.8 7e-05 23.3 0.1 10.9 5 2 8 13 13 11 6 Tetratricopeptide repeat TPR_7 PF13176.6 EGE00001.1 - 3.7e-15 54.8 19.4 0.042 13.9 0.1 9.2 8 1 0 8 8 8 5 Tetratricopeptide repeat TPR_9 PF13371.6 EGE00001.1 - 4.5e-15 55.5 14.5 0.0013 18.9 0.3 7.1 2 2 5 7 7 7 5 Tetratricopeptide repeat TPR_12 PF13424.6 EGE00001.1 - 1.8e-13 50.6 43.4 0.0002 21.6 0.8 8.6 5 2 4 9 9 8 4 Tetratricopeptide repeat ANAPC3 PF12895.7 EGE00001.1 - 7.7e-10 38.9 7.5 7.6e-08 32.5 2.0 3.7 3 1 1 4 4 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_15 PF13429.6 EGE00001.1 - 8.3e-06 25.2 26.5 0.037 13.3 0.1 6.2 2 1 3 6 6 6 3 Tetratricopeptide repeat DUF2225 PF09986.9 EGE00001.1 - 0.0015 18.3 4.3 0.93 9.2 0.0 2.9 2 1 0 2 2 2 2 Uncharacterized protein conserved in bacteria (DUF2225) ChAPs PF09295.10 EGE00001.1 - 0.34 9.9 2.3 3.1 6.7 0.4 2.7 3 0 0 3 3 3 0 ChAPs (Chs5p-Arf1p-binding proteins) TPR_10 PF13374.6 EGE00001.1 - 0.84 9.6 16.9 21 5.2 0.2 7.0 6 1 1 7 7 7 0 Tetratricopeptide repeat ImmE5 PF11480.8 EGE00002.1 - 0.099 13.1 0.2 0.11 13.0 0.2 1.2 1 0 0 1 1 1 0 Colicin-E5 Imm protein Ribosomal_L3 PF00297.22 EGE00003.1 - 5.9e-173 575.0 10.3 7.4e-173 574.7 10.3 1.0 1 0 0 1 1 1 1 Ribosomal protein L3 NuiA PF07924.11 EGE00004.1 - 0.00026 21.4 0.0 0.00086 19.7 0.0 1.8 1 1 0 1 1 1 1 Nuclease A inhibitor-like protein SR-25 PF10500.9 EGE00004.1 - 0.7 9.5 9.5 0.42 10.2 7.1 1.7 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein IMUP PF15761.5 EGE00004.1 - 5.3 7.8 10.2 0.42 11.3 4.7 1.9 2 0 0 2 2 2 0 Immortalisation up-regulated protein SKN1 PF03935.15 EGE00005.1 - 2e-223 742.3 0.1 2.4e-223 742.1 0.1 1.0 1 0 0 1 1 1 1 Beta-glucan synthesis-associated protein (SKN1) Trp_DMAT PF11991.8 EGE00006.1 - 7.6e-111 371.0 0.0 9.4e-111 370.7 0.0 1.1 1 0 0 1 1 1 1 Tryptophan dimethylallyltransferase FAD_binding_4 PF01565.23 EGE00007.1 - 5.8e-23 81.2 0.8 1.3e-22 80.0 0.8 1.6 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EGE00007.1 - 7.4e-10 38.8 0.3 1.6e-09 37.7 0.3 1.6 1 0 0 1 1 1 1 Berberine and berberine like Methyltransf_33 PF10017.9 EGE00008.1 - 8.3e-79 264.9 0.0 9.7e-79 264.7 0.0 1.0 1 0 0 1 1 1 1 Histidine-specific methyltransferase, SAM-dependent DUF4363 PF14276.6 EGE00008.1 - 0.049 13.7 0.1 0.1 12.7 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4363) adh_short_C2 PF13561.6 EGE00009.1 - 3.1e-41 141.5 0.0 4e-41 141.1 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EGE00009.1 - 3.6e-39 134.2 0.0 4.8e-39 133.8 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EGE00009.1 - 7.4e-13 48.8 0.3 1.3e-12 48.0 0.3 1.4 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 EGE00009.1 - 4.2e-06 26.4 0.0 2.8e-05 23.7 0.0 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 EGE00009.1 - 0.00029 20.1 0.0 0.00044 19.5 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein DUF4332 PF14229.6 EGE00009.1 - 0.0094 16.2 0.0 0.018 15.3 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4332) GDP_Man_Dehyd PF16363.5 EGE00009.1 - 0.023 14.1 0.0 0.044 13.2 0.0 1.4 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Catalase PF00199.19 EGE00010.1 - 4.9e-117 391.3 0.5 1e-98 331.0 0.2 2.1 1 1 1 2 2 2 2 Catalase Catalase-rel PF06628.12 EGE00010.1 - 1.6e-05 25.1 0.0 4.3e-05 23.6 0.0 1.8 1 0 0 1 1 1 1 Catalase-related immune-responsive Lumazine_bd_2 PF12893.7 EGE00011.1 - 6e-27 94.6 0.0 7e-27 94.4 0.0 1.1 1 0 0 1 1 1 1 Putative lumazine-binding DUF4878 PF12870.7 EGE00011.1 - 0.0023 18.2 0.2 0.017 15.4 0.2 2.1 1 1 0 1 1 1 1 Domain of unknown function (DUF4878) NmrA PF05368.13 EGE00012.1 - 2.8e-12 46.7 0.0 3.6e-12 46.4 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EGE00012.1 - 7.3e-11 42.3 0.0 1.3e-10 41.5 0.0 1.5 1 1 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EGE00012.1 - 7.7e-06 25.5 0.0 0.0077 15.7 0.0 2.3 2 0 0 2 2 2 2 NAD dependent epimerase/dehydratase family Sacchrp_dh_NADP PF03435.18 EGE00012.1 - 0.00034 20.9 0.1 0.00056 20.2 0.1 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain TrkA_N PF02254.18 EGE00012.1 - 0.00039 20.7 0.1 0.00061 20.0 0.1 1.3 1 0 0 1 1 1 1 TrkA-N domain PglD_N PF17836.1 EGE00012.1 - 0.0019 18.8 0.1 0.0053 17.4 0.1 1.7 1 0 0 1 1 1 1 PglD N-terminal domain LpxI_N PF17930.1 EGE00012.1 - 0.085 12.8 0.1 0.26 11.2 0.0 1.7 2 0 0 2 2 2 0 LpxI N-terminal domain GDP_Man_Dehyd PF16363.5 EGE00012.1 - 0.14 11.5 0.0 6.2 6.1 0.0 2.1 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase CoA_binding_3 PF13727.6 EGE00012.1 - 0.18 11.8 0.1 0.25 11.3 0.1 1.2 1 0 0 1 1 1 0 CoA-binding domain Ribonuc_L-PSP PF01042.21 EGE00013.1 - 1e-40 138.5 0.0 1.1e-40 138.4 0.0 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP Membr_traf_MHD PF10540.9 EGE00014.1 - 2.6e-19 69.9 0.2 1.7e-16 60.7 0.2 2.8 1 1 0 1 1 1 1 Munc13 (mammalian uncoordinated) homology domain C2 PF00168.30 EGE00014.1 - 2.1e-13 50.4 0.0 4.9e-13 49.3 0.0 1.7 1 0 0 1 1 1 1 C2 domain DUF810 PF05664.11 EGE00014.1 - 1.4e-07 30.5 0.3 1.4e-07 30.5 0.3 1.7 2 0 0 2 2 2 1 Plant family of unknown function (DUF810) NDUF_B8 PF05821.11 EGE00015.1 - 2.6e-06 27.4 0.0 3.1e-06 27.2 0.0 1.2 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8) SNF2_N PF00176.23 EGE00016.1 - 4.4e-63 213.1 0.7 7e-63 212.5 0.7 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EGE00016.1 - 3.4e-20 72.5 0.0 1.5e-19 70.4 0.1 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HSA PF07529.13 EGE00016.1 - 1.8e-09 37.8 7.2 7.1e-09 35.9 7.2 2.1 1 0 0 1 1 1 1 HSA ResIII PF04851.15 EGE00016.1 - 6e-09 36.1 0.0 1.5e-08 34.9 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EGE00016.1 - 2.5e-05 24.1 0.1 0.00066 19.5 0.0 2.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase MSA-2c PF12238.8 EGE00016.1 - 0.023 14.7 5.0 0.09 12.8 5.0 2.0 1 0 0 1 1 1 0 Merozoite surface antigen 2c DUF2486 PF10667.9 EGE00016.1 - 0.11 12.7 6.0 0.37 11.0 6.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2486) Clr5 PF14420.6 EGE00017.1 - 1.1e-13 51.1 1.2 1.1e-13 51.1 1.2 1.7 2 0 0 2 2 2 1 Clr5 domain ADH_zinc_N PF00107.26 EGE00018.1 - 8e-28 97.0 0.4 1.2e-27 96.4 0.4 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EGE00018.1 - 1.5e-11 45.4 0.0 3.1e-11 44.4 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EGE00018.1 - 4.1e-06 26.6 0.0 1.3e-05 25.0 0.0 1.9 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_N_2 PF16884.5 EGE00018.1 - 0.013 15.4 0.0 0.033 14.1 0.0 1.8 2 0 0 2 2 2 0 N-terminal domain of oxidoreductase adh_short PF00106.25 EGE00018.1 - 0.061 12.8 0.1 0.093 12.2 0.1 1.3 1 0 0 1 1 1 0 short chain dehydrogenase TrkA_N PF02254.18 EGE00018.1 - 0.064 13.5 0.0 0.11 12.7 0.0 1.3 1 0 0 1 1 1 0 TrkA-N domain HupF_HypC PF01455.18 EGE00018.1 - 0.21 11.8 0.5 0.68 10.1 0.1 2.1 2 0 0 2 2 2 0 HupF/HypC family Pep_deformylase PF01327.21 EGE00018.1 - 0.26 10.9 0.1 0.47 10.0 0.1 1.3 1 0 0 1 1 1 0 Polypeptide deformylase GRP PF07172.11 EGE00019.1 - 9.4 7.0 36.3 2.3e+02 2.5 36.3 2.2 1 1 0 1 1 1 0 Glycine rich protein family zf-Mss51 PF13824.6 EGE00020.1 - 4.1e-27 94.0 11.0 1.1e-26 92.6 11.0 1.8 1 1 0 1 1 1 1 Zinc-finger of mitochondrial splicing suppressor 51 zf-MYND PF01753.18 EGE00020.1 - 0.0047 17.0 2.8 0.0047 17.0 2.8 2.0 2 0 0 2 2 2 1 MYND finger Oxysterol_BP PF01237.18 EGE00021.1 - 1.1e-136 455.5 0.0 3.3e-136 454.0 0.0 1.7 2 0 0 2 2 2 1 Oxysterol-binding protein Ank_2 PF12796.7 EGE00021.1 - 1.1e-15 57.9 0.0 8e-08 32.8 0.0 3.1 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EGE00021.1 - 6.6e-15 55.0 0.1 4.4e-10 39.6 0.1 3.8 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 EGE00021.1 - 1.1e-10 41.4 0.1 0.0017 18.7 0.0 4.5 4 0 0 4 4 4 3 Ankyrin repeat Ank_3 PF13606.6 EGE00021.1 - 1.5e-10 40.4 0.0 0.00074 19.8 0.0 4.0 4 0 0 4 4 4 2 Ankyrin repeat Ank_4 PF13637.6 EGE00021.1 - 2.7e-07 31.0 0.1 0.00055 20.5 0.0 3.7 2 1 2 4 4 4 2 Ankyrin repeats (many copies) LLC1 PF14945.6 EGE00021.1 - 0.03 14.9 0.4 0.03 14.9 0.4 2.6 2 0 0 2 2 2 0 Normal lung function maintenance, Low in Lung Cancer 1 protein ATP12 PF07542.11 EGE00022.1 - 8.1e-42 142.4 0.2 1.2e-41 141.8 0.2 1.3 1 0 0 1 1 1 1 ATP12 chaperone protein UnbV_ASPIC PF07593.12 EGE00022.1 - 0.065 13.2 0.1 0.43 10.6 0.1 2.3 2 1 0 2 2 2 0 ASPIC and UnbV AP3D1 PF06375.11 EGE00025.1 - 0.012 15.8 5.8 0.014 15.7 5.8 1.0 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 Med19 PF10278.9 EGE00025.1 - 0.87 9.5 12.0 1 9.3 12.0 1.1 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 Presenilin PF01080.17 EGE00025.1 - 0.95 8.2 1.5 1 8.1 1.5 1.0 1 0 0 1 1 1 0 Presenilin Connexin PF00029.19 EGE00025.1 - 1.8 8.3 3.3 1.8 8.3 3.3 1.0 1 0 0 1 1 1 0 Connexin DUF1682 PF07946.14 EGE00025.1 - 3.9 6.6 13.1 4.2 6.5 13.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) Glyco_tranf_2_3 PF13641.6 EGE00026.1 - 3.2e-30 105.7 0.0 4.2e-30 105.3 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 EGE00026.1 - 5.4e-07 29.6 0.0 9.1e-07 28.8 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_transf_21 PF13506.6 EGE00026.1 - 1.1e-06 28.3 0.0 0.0011 18.5 0.0 2.3 2 0 0 2 2 2 2 Glycosyl transferase family 21 Glyco_trans_2_3 PF13632.6 EGE00026.1 - 0.0039 17.1 2.2 0.0039 17.1 2.2 2.2 2 0 0 2 2 2 1 Glycosyl transferase family group 2 SH3_1 PF00018.28 EGE00028.1 - 1.9e-14 53.0 0.0 2.8e-14 52.4 0.0 1.3 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EGE00028.1 - 1.5e-12 47.2 0.0 4.7e-12 45.6 0.0 1.8 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.17 EGE00028.1 - 1.2e-07 31.3 0.0 2e-07 30.5 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain MFS_1 PF07690.16 EGE00029.1 - 9.8e-15 54.3 64.0 1.5e-13 50.4 52.7 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MBF1 PF08523.10 EGE00030.1 - 1.1e-26 93.1 0.4 1.1e-26 93.1 0.4 1.7 2 1 0 2 2 2 1 Multiprotein bridging factor 1 HTH_3 PF01381.22 EGE00030.1 - 1.4e-11 44.3 0.1 3.2e-11 43.1 0.1 1.6 1 0 0 1 1 1 1 Helix-turn-helix HTH_31 PF13560.6 EGE00030.1 - 4.1e-07 30.2 0.4 1.3e-06 28.6 0.0 1.9 2 0 0 2 2 2 1 Helix-turn-helix domain Iso_dh PF00180.20 EGE00031.1 - 2.6e-70 237.3 0.0 3.2e-70 237.0 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase FTHFS PF01268.19 EGE00033.1 - 2e-253 841.6 0.0 3.9e-253 840.7 0.0 1.4 2 0 0 2 2 2 1 Formate--tetrahydrofolate ligase THF_DHG_CYH_C PF02882.19 EGE00033.1 - 1.2e-66 223.0 0.6 1.2e-66 223.0 0.6 1.8 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH PF00763.23 EGE00033.1 - 1.4e-35 122.0 0.2 3.1e-35 120.9 0.2 1.6 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain OCD_Mu_crystall PF02423.15 EGE00033.1 - 0.02 13.9 0.6 0.043 12.7 0.1 1.7 2 0 0 2 2 2 0 Ornithine cyclodeaminase/mu-crystallin family WD40 PF00400.32 EGE00034.1 - 1.8e-25 88.7 0.7 5.9e-07 30.1 0.0 6.2 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EGE00034.1 - 1.5e-13 50.8 0.0 0.0065 16.7 0.0 5.0 3 2 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EGE00034.1 - 0.0021 16.8 0.8 0.073 11.7 0.1 2.6 2 1 1 3 3 3 1 Nucleoporin Nup120/160 Gmad1 PF10647.9 EGE00034.1 - 0.028 14.2 0.0 0.11 12.2 0.0 2.0 1 1 0 1 1 1 0 Lipoprotein LpqB beta-propeller domain PQQ_2 PF13360.6 EGE00034.1 - 0.1 12.2 0.1 0.26 10.8 0.1 1.8 1 1 0 1 1 1 0 PQQ-like domain Pkinase PF00069.25 EGE00036.1 - 8.7e-11 41.7 0.0 1.9e-10 40.5 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGE00036.1 - 4.1e-06 26.3 0.0 3.4e-05 23.3 0.0 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase Kdo PF06293.14 EGE00036.1 - 0.03 13.7 0.0 0.054 12.8 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EGE00036.1 - 0.032 14.2 0.2 0.44 10.4 0.0 2.1 1 1 0 2 2 2 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EGE00036.1 - 0.091 11.5 0.0 0.13 11.0 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase DUF4589 PF15252.6 EGE00036.1 - 8.9 6.2 7.9 0.49 10.4 0.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4589) RrnaAD PF00398.20 EGE00038.1 - 0.0014 17.7 0.0 0.0027 16.8 0.0 1.4 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase DUF1524 PF07510.11 EGE00039.1 - 7.5e-07 29.1 0.0 9.5e-07 28.8 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1524) HNH_4 PF13395.6 EGE00039.1 - 0.01 15.8 0.9 0.047 13.6 0.9 2.0 1 1 0 1 1 1 1 HNH endonuclease DEAD PF00270.29 EGE00041.1 - 1.4e-16 60.8 0.4 5.3e-16 58.9 0.1 2.1 2 1 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EGE00041.1 - 4.3e-09 36.7 0.0 1.9e-08 34.6 0.0 2.2 1 1 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EGE00041.1 - 1.8e-07 31.3 0.0 4.2e-07 30.1 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DUF4332 PF14229.6 EGE00041.1 - 0.059 13.6 0.1 0.14 12.4 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4332) Vps53_N PF04100.12 EGE00042.1 - 4.1e-107 358.5 10.5 8.8e-107 357.4 10.5 1.5 1 0 0 1 1 1 1 Vps53-like, N-terminal Vps54_N PF10475.9 EGE00042.1 - 6.7e-08 32.2 6.8 1.3e-07 31.2 6.8 1.4 1 0 0 1 1 1 1 Vacuolar-sorting protein 54, of GARP complex DUF2451 PF10474.9 EGE00042.1 - 9.1e-05 22.3 0.1 0.0008 19.3 0.1 2.5 1 1 1 2 2 2 1 Protein of unknown function C-terminus (DUF2451) COG2 PF06148.11 EGE00042.1 - 0.0038 17.3 3.7 0.0095 16.0 2.4 2.5 2 0 0 2 2 2 1 COG (conserved oligomeric Golgi) complex component, COG2 Plk4_PB2 PF18409.1 EGE00042.1 - 0.19 12.4 6.9 2.5 8.8 0.6 4.2 2 1 2 4 4 4 0 Polo-like Kinase 4 Polo Box 2 DUF1910 PF08928.10 EGE00042.1 - 0.21 11.6 1.2 1.9 8.5 0.0 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF1910) Sporozoite_P67 PF05642.11 EGE00042.1 - 0.32 9.0 4.9 0.49 8.4 4.9 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen COG5 PF10392.9 EGE00042.1 - 0.32 11.2 7.4 0.42 10.8 3.3 3.2 3 0 0 3 3 3 0 Golgi transport complex subunit 5 TRPM_tetra PF16519.5 EGE00042.1 - 0.52 10.5 6.1 0.08 13.0 1.8 1.9 2 0 0 2 2 2 0 Tetramerisation domain of TRPM GIT1_C PF12205.8 EGE00042.1 - 0.95 9.6 8.5 1 9.5 1.1 2.8 1 1 1 2 2 2 0 G protein-coupled receptor kinase-interacting protein 1 C term TAP_C PF03943.13 EGE00043.1 - 2.4e-17 62.3 0.7 4.7e-17 61.4 0.7 1.5 1 0 0 1 1 1 1 TAP C-terminal domain LRR_9 PF14580.6 EGE00043.1 - 2.6e-06 27.1 0.0 4.1e-06 26.4 0.0 1.2 1 0 0 1 1 1 1 Leucine-rich repeat RRM_9 PF18444.1 EGE00043.1 - 5.6e-06 26.1 0.0 1.8e-05 24.5 0.0 2.0 1 1 0 1 1 1 1 RNA recognition motif NTF2 PF02136.20 EGE00043.1 - 3e-05 24.6 0.0 7.1e-05 23.4 0.0 1.7 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain LRR_4 PF12799.7 EGE00043.1 - 7.4e-05 23.0 5.6 0.0031 17.9 0.3 2.6 1 1 1 2 2 2 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EGE00043.1 - 0.015 15.1 0.2 0.039 13.7 0.2 1.8 1 0 0 1 1 1 0 Leucine rich repeat COPIIcoated_ERV PF07970.12 EGE00044.1 - 3.3e-80 269.1 0.0 5.4e-80 268.4 0.0 1.4 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 EGE00044.1 - 1.7e-29 102.0 0.0 4.6e-29 100.6 0.0 1.8 2 0 0 2 2 2 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) PH PF00169.29 EGE00045.1 - 2.5e-06 27.9 0.0 1.5e-05 25.4 0.0 2.3 2 0 0 2 2 2 1 PH domain zf-C2H2 PF00096.26 EGE00046.1 - 5.6e-25 86.4 59.2 0.00076 19.8 0.7 11.6 11 1 1 12 12 12 9 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EGE00046.1 - 3.2e-17 61.7 58.5 0.016 16.0 0.7 11.1 11 0 0 11 11 11 8 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EGE00046.1 - 1e-10 41.5 55.1 0.0033 17.8 0.2 11.0 11 1 1 12 12 11 6 Zinc-finger double domain FOXP-CC PF16159.5 EGE00046.1 - 0.00011 22.8 33.6 0.15 12.7 0.2 8.3 6 2 3 9 9 9 3 FOXP coiled-coil domain GAGA PF09237.11 EGE00046.1 - 0.00028 20.6 0.5 0.00028 20.6 0.5 2.2 2 0 0 2 2 2 1 GAGA factor zf-C2H2_8 PF15909.5 EGE00046.1 - 0.0091 16.3 19.7 0.16 12.3 2.0 4.5 3 1 3 6 6 6 4 C2H2-type zinc ribbon zf-C2H2_11 PF16622.5 EGE00046.1 - 0.016 15.0 20.3 4.4 7.1 0.0 6.3 6 0 0 6 6 6 0 zinc-finger C2H2-type zf-C2H2_3rep PF18868.1 EGE00046.1 - 0.042 14.5 16.4 6.7 7.4 0.6 5.2 4 3 1 5 5 5 0 Zinc finger C2H2-type, 3 repeats zf-C2H2_9 PF16293.5 EGE00046.1 - 0.064 13.1 2.5 2.5 8.0 0.7 3.5 2 0 0 2 2 2 0 C2H2 type zinc-finger (1 copy) zf-C2H2_jaz PF12171.8 EGE00046.1 - 0.07 13.4 19.9 2.6 8.4 0.0 8.0 10 0 0 10 10 10 0 Zinc-finger double-stranded RNA-binding DUF5472 PF17566.2 EGE00046.1 - 0.13 12.3 3.2 15 5.6 0.1 3.4 3 0 0 3 3 3 0 Family of unknown function (DUF5472) zf-C2H2_aberr PF17017.5 EGE00046.1 - 0.31 11.2 11.9 8.4 6.5 0.4 4.7 3 1 2 5 5 5 0 Aberrant zinc-finger CHORD PF04968.12 EGE00046.1 - 1.7 9.4 19.3 2.6 8.9 0.8 5.0 4 1 1 5 5 4 0 CHORD zf-met PF12874.7 EGE00046.1 - 7.2 7.2 12.7 73 4.0 0.0 6.6 7 0 0 7 7 7 0 Zinc-finger of C2H2 type RNA_pol_Rpb6 PF01192.22 EGE00047.1 - 6.2e-17 61.3 0.1 8.8e-17 60.8 0.1 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb6 MFS_1 PF07690.16 EGE00049.1 - 2.3e-22 79.4 53.3 1.1e-17 64.0 37.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Acetyltransf_1 PF00583.25 EGE00050.1 - 3.6e-11 43.3 0.0 4.9e-11 42.9 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EGE00050.1 - 3.3e-09 36.8 0.0 5.6e-09 36.0 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EGE00050.1 - 2.3e-06 27.5 0.0 3.4e-06 26.9 0.0 1.2 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_7 PF13508.7 EGE00050.1 - 2.3e-06 27.9 0.0 3.3e-06 27.4 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EGE00050.1 - 0.00018 21.6 0.1 0.00027 21.0 0.1 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 EGE00050.1 - 0.13 12.4 0.0 0.28 11.3 0.0 1.5 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain CENP-Q PF13094.6 EGE00051.1 - 0.053 13.7 1.2 0.4 10.9 0.2 2.4 2 0 0 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit Phage_NinH PF06322.11 EGE00051.1 - 0.067 13.1 0.1 0.13 12.2 0.1 1.4 1 0 0 1 1 1 0 Phage NinH protein Lectin_N PF03954.14 EGE00051.1 - 0.85 9.4 3.8 5.7 6.7 1.4 2.2 2 0 0 2 2 2 0 Hepatic lectin, N-terminal domain PCI PF01399.27 EGE00052.1 - 2.2e-12 47.4 0.6 1e-10 42.0 0.0 3.2 2 0 0 2 2 2 1 PCI domain BAH PF01426.18 EGE00052.1 - 0.0026 17.6 0.3 0.0075 16.1 0.3 1.9 1 1 0 1 1 1 1 BAH domain Pro_Al_protease PF02983.14 EGE00052.1 - 0.043 13.9 0.0 0.35 11.0 0.0 2.7 1 0 0 1 1 1 0 Alpha-lytic protease prodomain DUF2052 PF09747.9 EGE00053.1 - 0.0004 20.6 4.4 0.0004 20.6 4.4 1.1 1 0 0 1 1 1 1 Coiled-coil domain containing protein (DUF2052) RR_TM4-6 PF06459.12 EGE00053.1 - 0.038 13.8 4.2 0.042 13.7 4.2 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 FAM176 PF14851.6 EGE00053.1 - 0.074 12.7 7.3 0.12 12.1 7.3 1.3 1 0 0 1 1 1 0 FAM176 family DUF4820 PF16091.5 EGE00053.1 - 0.14 11.5 2.4 0.14 11.5 2.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) Presenilin PF01080.17 EGE00053.1 - 0.17 10.6 1.5 0.17 10.6 1.5 1.0 1 0 0 1 1 1 0 Presenilin CDC45 PF02724.14 EGE00053.1 - 0.18 10.1 7.3 0.17 10.1 7.3 1.0 1 0 0 1 1 1 0 CDC45-like protein Nop14 PF04147.12 EGE00053.1 - 0.6 8.2 10.0 0.53 8.4 10.0 1.0 1 0 0 1 1 1 0 Nop14-like family RPN2_C PF18004.1 EGE00053.1 - 0.89 9.5 9.2 1.1 9.1 9.2 1.1 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Radial_spoke PF04712.12 EGE00053.1 - 1.7 7.5 11.1 2.1 7.2 11.1 1.0 1 0 0 1 1 1 0 Radial spokehead-like protein NPR3 PF03666.13 EGE00053.1 - 1.8 7.3 4.7 1.9 7.2 4.7 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 V_ATPase_I PF01496.19 EGE00053.1 - 2.7 5.8 3.0 2.9 5.7 3.0 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Myc_N PF01056.18 EGE00053.1 - 3 7.7 7.0 3.2 7.6 7.0 1.1 1 0 0 1 1 1 0 Myc amino-terminal region DNA_pol_phi PF04931.13 EGE00053.1 - 5.9 4.9 16.7 7.1 4.6 16.7 1.0 1 0 0 1 1 1 0 DNA polymerase phi DUF4637 PF15470.6 EGE00053.1 - 6.1 6.6 15.6 8.7 6.1 15.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) DDRGK PF09756.9 EGE00053.1 - 6.1 6.4 18.3 7.6 6.1 18.3 1.1 1 0 0 1 1 1 0 DDRGK domain Pox_Ag35 PF03286.14 EGE00053.1 - 8 6.2 10.2 11 5.7 10.2 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein PBP_sp32 PF07222.12 EGE00053.1 - 8.8 5.7 9.2 11 5.5 9.2 1.1 1 0 0 1 1 1 0 Proacrosin binding protein sp32 G-gamma PF00631.22 EGE00054.1 - 5.7e-21 74.3 0.0 6.5e-21 74.1 0.0 1.1 1 0 0 1 1 1 1 GGL domain Neuraminidase PF18413.1 EGE00055.1 - 0.44 10.2 4.6 0.31 10.7 0.2 2.1 2 0 0 2 2 2 0 Neuraminidase-like domain Ofd1_CTDD PF10637.9 EGE00057.1 - 1.4e-93 313.0 0.0 3.5e-91 305.1 0.1 2.2 2 0 0 2 2 2 2 Oxoglutarate and iron-dependent oxygenase degradation C-term 2OG-FeII_Oxy_4 PF13661.6 EGE00057.1 - 6e-25 87.7 0.0 2.6e-24 85.7 0.0 2.1 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_3 PF13640.6 EGE00057.1 - 8.7e-14 52.2 0.0 1.7e-13 51.3 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily BUD22 PF09073.10 EGE00057.1 - 6 6.1 19.0 0.055 12.8 8.6 2.2 2 0 0 2 2 2 0 BUD22 APH PF01636.23 EGE00058.1 - 9.7e-08 32.2 0.0 4.8e-07 30.0 0.0 2.1 2 0 0 2 2 2 1 Phosphotransferase enzyme family Clathrin_H_link PF13838.6 EGE00059.1 - 0.12 12.3 0.7 0.98 9.4 0.6 2.2 2 0 0 2 2 2 0 Clathrin-H-link COesterase PF00135.28 EGE00060.1 - 8.5e-80 269.0 0.0 1.1e-79 268.7 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EGE00060.1 - 6.2e-07 29.5 0.2 6.9e-06 26.1 0.2 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Endopep_inhib PF16800.5 EGE00060.1 - 0.21 11.5 0.0 0.47 10.4 0.0 1.5 1 0 0 1 1 1 0 IseA DL-endopeptidase inhibitor p450 PF00067.22 EGE00062.1 - 8.9e-67 225.8 0.0 1.2e-66 225.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Sdh_cyt PF01127.22 EGE00062.1 - 0.019 15.0 0.5 0.038 14.0 0.5 1.4 1 0 0 1 1 1 0 Succinate dehydrogenase/Fumarate reductase transmembrane subunit FAD_binding_4 PF01565.23 EGE00063.1 - 5.2e-34 117.0 7.0 1.9e-33 115.2 6.5 2.0 2 0 0 2 2 2 1 FAD binding domain BBE PF08031.12 EGE00063.1 - 0.0058 16.7 0.0 0.012 15.7 0.0 1.6 1 0 0 1 1 1 1 Berberine and berberine like FAD_binding_4 PF01565.23 EGE00064.1 - 1.9e-19 69.8 0.8 3.6e-19 68.9 0.8 1.5 1 0 0 1 1 1 1 FAD binding domain DRMBL PF07522.14 EGE00065.1 - 2.2e-33 114.7 0.0 4.6e-33 113.7 0.0 1.6 1 0 0 1 1 1 1 DNA repair metallo-beta-lactamase Lactamase_B_2 PF12706.7 EGE00065.1 - 4.4e-05 23.1 0.0 0.00015 21.4 0.0 1.9 2 0 0 2 2 2 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 EGE00065.1 - 0.032 14.2 0.2 0.066 13.2 0.2 1.5 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily LSM PF01423.22 EGE00066.1 - 3.9e-18 64.9 0.8 5.1e-18 64.5 0.8 1.2 1 0 0 1 1 1 1 LSM domain Hfq PF17209.3 EGE00066.1 - 0.017 14.7 0.0 0.028 14.0 0.0 1.3 1 0 0 1 1 1 0 Hfq protein DUF402 PF04167.13 EGE00066.1 - 0.054 13.7 0.4 0.074 13.3 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF402) Methyltransf_11 PF08241.12 EGE00067.1 - 7.1e-07 29.8 0.0 1.5e-06 28.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EGE00067.1 - 0.067 13.9 0.0 0.18 12.6 0.0 1.8 1 1 0 1 1 1 0 Methyltransferase domain zf-BED PF02892.15 EGE00068.1 - 0.00096 19.1 5.5 0.29 11.2 0.3 2.6 2 0 0 2 2 2 2 BED zinc finger SH3BGR PF04908.15 EGE00070.1 - 0.00075 19.6 0.0 0.0032 17.6 0.0 2.1 1 0 0 1 1 1 1 SH3-binding, glutamic acid-rich protein Glutaredoxin PF00462.24 EGE00070.1 - 0.11 12.8 0.1 0.48 10.7 0.0 2.1 2 0 0 2 2 2 0 Glutaredoxin Pkinase PF00069.25 EGE00071.1 - 8.5e-22 77.8 0.0 1.4e-21 77.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGE00071.1 - 7.2e-08 32.0 0.0 9.1e-08 31.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EGE00071.1 - 0.006 15.4 0.0 0.0094 14.8 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EGE00071.1 - 0.013 15.4 0.2 0.033 14.1 0.2 1.7 1 1 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.14 EGE00071.1 - 0.052 12.9 0.0 0.096 12.0 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Ribul_P_3_epim PF00834.19 EGE00072.1 - 1.6e-61 207.1 0.0 2.4e-60 203.3 0.0 2.0 1 1 0 1 1 1 1 Ribulose-phosphate 3 epimerase family Melibiase PF02065.18 EGE00072.1 - 0.0052 15.8 0.1 0.29 10.1 0.0 2.2 2 0 0 2 2 2 2 Melibiase ThiG PF05690.14 EGE00072.1 - 0.06 12.7 0.4 0.083 12.2 0.4 1.2 1 0 0 1 1 1 0 Thiazole biosynthesis protein ThiG zf-C2H2_4 PF13894.6 EGE00073.1 - 0.53 11.3 13.0 0.42 11.6 0.4 4.2 4 0 0 4 4 4 0 C2H2-type zinc finger zf-C2H2 PF00096.26 EGE00073.1 - 0.9 10.1 14.4 4.7 7.9 0.3 4.4 4 0 0 4 4 4 0 Zinc finger, C2H2 type DUF3834 PF12916.7 EGE00075.1 - 0.16 11.2 0.0 0.22 10.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3834) ABC2_membrane PF01061.24 EGE00076.1 - 2.2e-86 288.6 59.7 1.7e-44 151.8 19.7 3.1 3 0 0 3 3 3 2 ABC-2 type transporter ABC_tran PF00005.27 EGE00076.1 - 2.1e-36 125.5 0.0 7.8e-17 62.1 0.0 2.6 2 0 0 2 2 2 2 ABC transporter PDR_CDR PF06422.12 EGE00076.1 - 8.5e-33 112.1 10.1 7.7e-31 105.8 0.1 3.7 4 0 0 4 4 4 2 CDR ABC transporter ABC_trans_N PF14510.6 EGE00076.1 - 1.8e-18 67.0 0.0 4.1e-18 65.8 0.0 1.7 1 0 0 1 1 1 1 ABC-transporter N-terminal AAA_16 PF13191.6 EGE00076.1 - 3.3e-07 30.8 0.2 0.0018 18.7 0.0 2.7 3 0 0 3 3 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 EGE00076.1 - 4e-06 26.8 0.1 0.0012 18.8 0.0 2.6 2 0 0 2 2 2 1 RsgA GTPase ABC2_membrane_3 PF12698.7 EGE00076.1 - 9.2e-06 25.0 53.6 0.005 16.0 19.6 2.9 2 1 0 2 2 2 2 ABC-2 family transporter protein AAA_25 PF13481.6 EGE00076.1 - 1.5e-05 24.6 0.1 0.00011 21.8 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EGE00076.1 - 2.1e-05 24.7 0.1 0.0012 19.0 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 EGE00076.1 - 0.00013 22.5 0.1 0.013 16.1 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 EGE00076.1 - 0.00096 18.8 2.4 0.046 13.5 0.1 2.8 3 0 0 3 3 2 1 P-loop containing region of AAA domain AAA_21 PF13304.6 EGE00076.1 - 0.002 18.0 0.0 2.3 7.9 0.0 3.2 3 0 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 EGE00076.1 - 0.0036 17.6 0.4 1.7 8.9 0.1 2.7 2 0 0 2 2 2 1 AAA domain cobW PF02492.19 EGE00076.1 - 0.016 14.8 1.2 0.3 10.6 0.1 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_30 PF13604.6 EGE00076.1 - 0.017 14.8 0.4 2.2 8.0 0.4 2.4 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 EGE00076.1 - 0.027 14.5 0.2 9.4 6.4 0.0 2.5 2 0 0 2 2 2 0 50S ribosome-binding GTPase SMC_N PF02463.19 EGE00076.1 - 0.035 13.5 0.0 2.2 7.7 0.0 3.0 3 1 0 3 3 3 0 RecF/RecN/SMC N terminal domain AAA_28 PF13521.6 EGE00076.1 - 0.089 13.0 0.1 1.8 8.8 0.0 2.4 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 EGE00076.1 - 0.099 12.5 2.1 4.2 7.3 0.2 2.9 3 0 0 3 3 3 0 NACHT domain Viral_helicase1 PF01443.18 EGE00076.1 - 0.12 12.1 0.0 4.2 7.0 0.0 2.4 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase MS_channel PF00924.18 EGE00078.1 - 1.1e-24 87.2 2.4 2.6e-24 85.9 2.4 1.6 1 0 0 1 1 1 1 Mechanosensitive ion channel EF-hand_5 PF13202.6 EGE00078.1 - 1.2e-05 24.6 0.1 3e-05 23.3 0.1 1.7 1 0 0 1 1 1 1 EF hand EF-hand_1 PF00036.32 EGE00078.1 - 9.6e-05 21.7 0.3 0.00022 20.5 0.3 1.7 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 EGE00078.1 - 0.00028 20.6 0.1 0.00091 19.0 0.1 1.9 1 0 0 1 1 1 1 EF-hand domain EF-hand_7 PF13499.6 EGE00078.1 - 0.005 17.3 0.5 0.012 16.0 0.5 1.6 1 0 0 1 1 1 1 EF-hand domain pair Scramblase PF03803.15 EGE00078.1 - 0.11 11.7 0.0 0.25 10.6 0.0 1.5 1 0 0 1 1 1 0 Scramblase Ferlin_C PF16165.5 EGE00078.1 - 0.5 10.3 0.0 0.5 10.3 0.0 2.4 3 0 0 3 3 3 0 Ferlin C-terminus CDH-cyt PF16010.5 EGE00079.1 - 0.12 12.0 0.1 0.13 11.9 0.1 1.2 1 0 0 1 1 1 0 Cytochrome domain of cellobiose dehydrogenase Tubulin PF00091.25 EGE00080.1 - 5.1e-65 219.4 0.0 6.7e-65 219.0 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EGE00080.1 - 2e-44 150.8 0.0 3.1e-44 150.2 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 EGE00080.1 - 0.00037 20.2 0.0 0.00069 19.3 0.0 1.4 1 0 0 1 1 1 1 Tubulin domain Mito_carr PF00153.27 EGE00081.1 - 1.6e-64 213.8 3.0 3.9e-20 71.6 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 EGE00081.1 - 0.41 9.8 2.0 4.2 6.5 0.0 3.2 4 0 0 4 4 4 0 Gammaproteobacterial serine protease TauD PF02668.16 EGE00082.1 - 5e-44 151.1 0.0 7.1e-44 150.6 0.0 1.2 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family DUF971 PF06155.12 EGE00082.1 - 9.9e-07 29.3 0.0 2.3e-06 28.2 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF971) CsiD PF08943.10 EGE00082.1 - 0.0096 15.1 0.0 0.016 14.3 0.0 1.3 1 0 0 1 1 1 1 CsiD PhyH PF05721.13 EGE00082.1 - 0.14 12.4 0.0 1 9.5 0.0 2.1 2 0 0 2 2 2 0 Phytanoyl-CoA dioxygenase (PhyH) Glutaredoxin PF00462.24 EGE00083.1 - 1.1e-18 67.2 0.0 1.2e-16 60.7 0.0 2.5 2 0 0 2 2 2 1 Glutaredoxin Thioredoxin PF00085.20 EGE00083.1 - 6e-12 45.5 0.0 1.5e-11 44.2 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 EGE00083.1 - 0.00055 20.2 0.0 0.072 13.4 0.0 2.4 1 1 1 2 2 2 2 Thioredoxin-like Thioredoxin_2 PF13098.6 EGE00083.1 - 0.0054 17.2 0.0 0.056 13.9 0.0 2.5 2 2 0 2 2 2 1 Thioredoxin-like domain OST3_OST6 PF04756.13 EGE00083.1 - 0.02 14.3 0.0 0.028 13.8 0.0 1.2 1 0 0 1 1 1 0 OST3 / OST6 family, transporter family OPT PF03169.15 EGE00084.1 - 1.9e-166 555.3 49.7 1.9e-149 499.2 42.5 2.0 1 1 1 2 2 2 2 OPT oligopeptide transporter protein DUF4191 PF13829.6 EGE00084.1 - 0.092 12.1 1.3 0.33 10.3 1.3 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4191) SlyX PF04102.12 EGE00086.1 - 0.0057 17.3 0.5 2.1 9.0 0.1 3.1 3 0 0 3 3 3 1 SlyX Med9 PF07544.13 EGE00086.1 - 0.021 14.9 0.0 11 6.1 0.0 2.6 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 SIKE PF05769.11 EGE00086.1 - 0.036 14.0 0.9 0.094 12.6 0.9 1.7 1 1 0 1 1 1 0 SIKE family LPP PF04728.13 EGE00086.1 - 0.095 13.1 0.4 1 9.8 0.0 2.2 2 0 0 2 2 2 0 Lipoprotein leucine-zipper FapA PF03961.13 EGE00086.1 - 0.095 11.3 0.0 0.13 10.8 0.0 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A DUF3050 PF11251.8 EGE00086.1 - 0.13 11.9 0.0 0.3 10.7 0.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3050) Spc24 PF08286.11 EGE00086.1 - 0.16 12.2 0.1 8.9 6.6 0.1 2.3 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 KIAA1430 PF13879.6 EGE00086.1 - 0.4 11.5 3.7 0.37 11.6 1.6 2.4 2 1 0 2 2 2 0 KIAA1430 homologue ATG16 PF08614.11 EGE00086.1 - 3.4 7.8 7.0 0.88 9.8 0.1 2.8 3 1 0 3 3 3 0 Autophagy protein 16 (ATG16) Beta_elim_lyase PF01212.21 EGE00087.1 - 6.8e-67 225.8 0.0 8.3e-67 225.5 0.0 1.1 1 0 0 1 1 1 1 Beta-eliminating lyase CN_hydrolase PF00795.22 EGE00088.1 - 2.2e-43 148.5 0.1 2.8e-43 148.1 0.1 1.0 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase Pkinase PF00069.25 EGE00090.1 - 5.6e-66 222.6 0.0 1.3e-65 221.4 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGE00090.1 - 1.7e-33 116.0 0.0 2.8e-33 115.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase FHA PF00498.26 EGE00090.1 - 3.6e-09 36.9 0.9 2.9e-08 33.9 0.2 2.7 3 0 0 3 3 3 1 FHA domain Yop-YscD_cpl PF16697.5 EGE00090.1 - 0.00059 20.1 0.0 0.0014 18.9 0.0 1.5 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain Ribonuc_P_40 PF08584.11 EGE00090.1 - 0.0079 15.5 0.7 0.018 14.3 0.7 1.5 1 0 0 1 1 1 1 Ribonuclease P 40kDa (Rpp40) subunit RIO1 PF01163.22 EGE00090.1 - 0.02 14.5 0.1 0.036 13.7 0.1 1.3 1 0 0 1 1 1 0 RIO1 family Kinase-like PF14531.6 EGE00090.1 - 0.032 13.6 0.0 0.09 12.1 0.0 1.7 1 1 0 1 1 1 0 Kinase-like Kdo PF06293.14 EGE00090.1 - 0.061 12.7 0.0 0.12 11.7 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EGE00090.1 - 0.098 12.6 0.0 0.3 11.0 0.0 1.7 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EGE00090.1 - 0.2 10.4 0.9 0.55 8.9 0.0 1.9 2 0 0 2 2 2 0 Fungal protein kinase TFR_dimer PF04253.15 EGE00092.1 - 2.4e-23 82.5 0.0 3.7e-23 81.9 0.0 1.3 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain Peptidase_M28 PF04389.17 EGE00092.1 - 2.4e-21 76.3 0.0 4.1e-21 75.6 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.22 EGE00092.1 - 2e-10 40.5 0.5 2.3e-09 37.1 0.4 2.7 2 1 0 2 2 2 1 PA domain Peptidase_M20 PF01546.28 EGE00092.1 - 0.01 15.6 0.0 0.019 14.7 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 Glyco_transf_34 PF05637.12 EGE00093.1 - 1.1e-61 208.6 0.0 1.7e-61 208.0 0.0 1.3 1 0 0 1 1 1 1 galactosyl transferase GMA12/MNN10 family GPR15L PF15854.5 EGE00093.1 - 0.052 13.8 0.0 0.13 12.6 0.0 1.7 1 0 0 1 1 1 0 G-protein coupled receptor ligand 15 NDUFB10 PF10249.9 EGE00094.1 - 0.034 14.6 0.0 0.037 14.5 0.0 1.1 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase subunit 10 BRO1 PF03097.18 EGE00095.1 - 1.6e-14 53.5 0.8 3.7e-14 52.3 0.8 1.6 1 1 0 1 1 1 1 BRO1-like domain TAFII55_N PF04658.13 EGE00096.1 - 1.3e-52 177.8 0.3 1.3e-51 174.5 0.0 2.2 2 0 0 2 2 2 1 TAFII55 protein conserved region NinE PF05322.11 EGE00096.1 - 0.057 13.3 0.0 0.14 12.1 0.0 1.7 1 0 0 1 1 1 0 NINE Protein AAA_13 PF13166.6 EGE00096.1 - 8.7 4.8 8.9 0.33 9.6 3.0 1.5 2 0 0 2 2 2 0 AAA domain Bromo_TP PF07524.13 EGE00097.1 - 5.8e-10 39.0 0.0 1e-09 38.3 0.0 1.3 1 0 0 1 1 1 1 Bromodomain associated TFIID-31kDa PF02291.15 EGE00097.1 - 0.021 14.9 0.0 0.033 14.3 0.0 1.2 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit LysM PF01476.20 EGE00098.1 - 1.1e-06 28.5 0.3 5.9e-05 23.0 0.0 3.0 4 0 0 4 4 4 1 LysM domain Ank_2 PF12796.7 EGE00100.1 - 1.6e-36 124.7 0.0 3.4e-11 43.6 0.0 5.1 3 1 3 6 6 6 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EGE00100.1 - 3.7e-28 97.5 4.6 8e-07 29.5 0.0 6.6 3 3 4 7 7 7 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 EGE00100.1 - 7e-25 84.4 4.4 0.04 14.5 0.0 10.0 10 0 0 10 10 10 7 Ankyrin repeat Ank PF00023.30 EGE00100.1 - 5.2e-18 64.6 4.8 0.14 12.7 0.0 8.1 9 0 0 9 9 9 5 Ankyrin repeat Ank_5 PF13857.6 EGE00100.1 - 1.5e-16 60.2 5.3 0.003 17.8 0.0 8.5 2 2 7 9 9 9 3 Ankyrin repeats (many copies) FAD_binding_7 PF03441.14 EGE00102.1 - 4e-80 268.1 1.2 6.2e-80 267.5 0.2 1.8 2 0 0 2 2 2 1 FAD binding domain of DNA photolyase DNA_photolyase PF00875.18 EGE00102.1 - 6.1e-41 140.2 0.1 1.2e-40 139.2 0.1 1.5 1 0 0 1 1 1 1 DNA photolyase GFA PF04828.14 EGE00103.1 - 2.5e-16 59.8 1.3 3e-16 59.5 1.3 1.1 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme DUF2757 PF10955.8 EGE00103.1 - 0.082 13.2 1.5 0.18 12.1 1.5 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF2757) Med16 PF11635.8 EGE00103.1 - 0.18 9.7 0.4 0.18 9.7 0.4 1.1 1 0 0 1 1 1 0 Mediator complex subunit 16 APH PF01636.23 EGE00104.1 - 2e-14 54.1 0.0 1.2e-13 51.5 0.0 2.1 1 1 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.20 EGE00104.1 - 0.0047 16.3 0.0 0.0075 15.6 0.0 1.2 1 0 0 1 1 1 1 Ecdysteroid kinase DUF1679 PF07914.11 EGE00104.1 - 0.0068 15.3 0.1 0.052 12.4 0.0 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF1679) adh_short PF00106.25 EGE00106.1 - 1.2e-09 38.0 0.0 1.9e-09 37.3 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EGE00106.1 - 3.7e-08 33.5 0.0 6e-08 32.8 0.0 1.3 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.6 EGE00106.1 - 1e-06 28.5 0.0 1.6e-06 27.9 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Glyco_tran_WecB PF03808.13 EGE00106.1 - 0.09 12.7 0.0 0.18 11.7 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase WecB/TagA/CpsF family Peptidase_M36 PF02128.15 EGE00107.1 - 1.3e-160 534.6 2.4 1.6e-160 534.3 2.4 1.1 1 0 0 1 1 1 1 Fungalysin metallopeptidase (M36) FTP PF07504.13 EGE00107.1 - 3.1e-17 62.2 2.3 6.7e-17 61.1 2.3 1.5 1 0 0 1 1 1 1 Fungalysin/Thermolysin Propeptide Motif DUF5122 PF17164.4 EGE00107.1 - 0.0094 16.2 0.3 0.6 10.5 0.2 3.1 2 0 0 2 2 2 1 Domain of unknown function (DUF5122) beta-propeller Peptidase_M14 PF00246.24 EGE00108.1 - 6.8e-15 55.6 0.0 9.7e-15 55.1 0.0 1.2 1 0 0 1 1 1 1 Zinc carboxypeptidase AstE_AspA PF04952.14 EGE00108.1 - 0.01 14.9 0.0 0.021 13.9 0.0 1.5 1 0 0 1 1 1 0 Succinylglutamate desuccinylase / Aspartoacylase family DUF2817 PF10994.8 EGE00108.1 - 0.03 13.7 0.0 0.049 13.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2817) Aldo_ket_red PF00248.21 EGE00109.1 - 2.8e-51 174.5 0.0 4.2e-51 173.9 0.0 1.2 1 0 0 1 1 1 1 Aldo/keto reductase family tRNA-synt_1c PF00749.21 EGE00110.1 - 5.1e-91 304.8 0.0 1.1e-90 303.7 0.0 1.5 2 0 0 2 2 2 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.18 EGE00110.1 - 6.3e-34 117.3 0.1 9.5e-34 116.8 0.1 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain Glyco_hydro_3 PF00933.21 EGE00111.1 - 9.3e-79 265.1 0.0 1.2e-78 264.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Acetyltransf_1 PF00583.25 EGE00111.1 - 6.3e-16 58.7 0.0 8.2e-09 35.7 0.0 2.5 2 0 0 2 2 2 2 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EGE00111.1 - 9.9e-16 57.9 0.0 2.5e-06 27.8 0.0 2.6 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EGE00111.1 - 1.7e-12 47.4 0.0 4.8e-06 26.5 0.0 2.9 3 0 0 3 3 3 2 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EGE00111.1 - 3.7e-06 27.0 0.0 0.015 15.4 0.0 2.6 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 EGE00111.1 - 2.5e-05 24.3 0.2 0.015 15.4 0.1 3.4 3 0 0 3 3 3 1 GCN5-related N-acetyl-transferase Glyco_hydro_3_C PF01915.22 EGE00111.1 - 4.5e-05 23.5 0.0 0.00031 20.8 0.0 2.2 2 1 0 2 2 2 1 Glycosyl hydrolase family 3 C-terminal domain FR47 PF08445.10 EGE00111.1 - 6.2e-05 22.9 0.1 0.079 12.9 0.0 2.7 2 0 0 2 2 2 2 FR47-like protein TrkA_N PF02254.18 EGE00111.1 - 0.14 12.4 0.1 0.5 10.6 0.1 1.9 1 0 0 1 1 1 0 TrkA-N domain Acetyltransf_6 PF13480.7 EGE00111.1 - 0.25 11.5 1.2 8.6 6.5 0.0 2.9 3 0 0 3 3 3 0 Acetyltransferase (GNAT) domain PDEase_I PF00233.19 EGE00112.1 - 1.5e-30 106.7 0.0 2.5e-30 106.0 0.0 1.3 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase Ribosomal_L10 PF00466.20 EGE00113.1 - 6.8e-24 83.9 0.1 1.8e-23 82.5 0.0 1.8 2 0 0 2 2 2 1 Ribosomal protein L10 RL10P_insert PF17777.1 EGE00113.1 - 1.1e-20 73.4 0.1 2e-20 72.6 0.1 1.4 1 0 0 1 1 1 1 Insertion domain in 60S ribosomal protein L10P Ribosomal_60s PF00428.19 EGE00113.1 - 8.6e-12 45.5 1.1 2e-11 44.3 0.3 1.9 2 0 0 2 2 2 1 60s Acidic ribosomal protein WD40 PF00400.32 EGE00114.1 - 0.0072 17.2 3.3 0.21 12.5 0.8 3.8 4 0 0 4 4 4 1 WD domain, G-beta repeat URO-D PF01208.17 EGE00115.1 - 6.4e-131 436.6 0.0 7.1e-131 436.5 0.0 1.0 1 0 0 1 1 1 1 Uroporphyrinogen decarboxylase (URO-D) Nod1 PF17114.5 EGE00115.1 - 0.13 12.4 0.0 0.2 11.8 0.0 1.2 1 0 0 1 1 1 0 Gef2-related medial cortical node protein Nod1 DnaJ_C PF01556.18 EGE00116.1 - 5.5e-39 133.6 0.0 7.2e-39 133.2 0.0 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 EGE00116.1 - 5.9e-21 74.4 1.6 9.7e-21 73.7 1.6 1.4 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 EGE00116.1 - 9.5e-15 54.7 18.3 1.6e-14 54.0 18.3 1.4 1 0 0 1 1 1 1 DnaJ central domain HypA PF01155.19 EGE00116.1 - 1.3 9.0 9.9 1.5 8.9 2.3 2.3 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA FXR_C1 PF16096.5 EGE00117.1 - 0.017 15.3 5.5 0.017 15.3 5.5 1.9 2 0 0 2 2 2 0 Fragile X-related 1 protein C-terminal region 2 Sulfate_transp PF00916.20 EGE00118.1 - 1.8e-104 349.5 21.2 2.4e-104 349.1 21.2 1.1 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 EGE00118.1 - 4.4e-07 29.6 0.0 8.1e-07 28.7 0.0 1.4 1 0 0 1 1 1 1 STAS domain MFS_1 PF07690.16 EGE00119.1 - 1.1e-30 106.8 61.8 4.3e-27 95.0 53.6 3.6 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 EGE00119.1 - 2.6e-13 49.3 11.5 5.3e-13 48.3 11.5 1.4 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) DSBA PF01323.20 EGE00120.1 - 7.6e-32 110.7 0.0 9.4e-32 110.3 0.0 1.0 1 0 0 1 1 1 1 DSBA-like thioredoxin domain Thioredoxin_4 PF13462.6 EGE00120.1 - 0.00021 21.5 0.6 0.0029 17.8 0.0 2.3 1 1 0 2 2 2 1 Thioredoxin Rab5ip PF07019.12 EGE00121.1 - 2.4e-22 79.3 3.4 3.1e-22 79.0 3.4 1.1 1 0 0 1 1 1 1 Rab5-interacting protein (Rab5ip) DUF5084 PF16894.5 EGE00121.1 - 0.5 10.8 4.9 0.69 10.4 0.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF5084) RPA43_OB PF17875.1 EGE00122.1 - 1.6e-40 138.6 0.1 1.6e-40 138.6 0.1 3.4 3 0 0 3 3 3 1 RPA43 OB domain in RNA Pol I DnaJ PF00226.31 EGE00123.1 - 1.8e-12 47.2 0.0 4.6e-12 45.9 0.0 1.8 1 0 0 1 1 1 1 DnaJ domain HXXEE PF13787.6 EGE00123.1 - 0.37 11.6 4.2 0.2 12.5 0.8 2.1 2 0 0 2 2 2 0 Protein of unknown function with HXXEE motif INO80_Ies4 PF08193.11 EGE00124.1 - 7.7e-70 235.6 31.6 7.7e-70 235.6 31.6 1.8 1 1 1 2 2 2 1 INO80 complex subunit Ies4 SpoIIP PF07454.11 EGE00124.1 - 0.62 9.5 6.4 1 8.7 6.4 1.3 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) FGF-BP1 PF06473.12 EGE00124.1 - 1 9.1 13.2 0.16 11.8 7.9 2.0 2 0 0 2 2 2 0 FGF binding protein 1 (FGF-BP1) CPSF100_C PF13299.6 EGE00124.1 - 1.7 8.8 10.5 0.44 10.7 5.0 2.1 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal MCM_bind PF09739.9 EGE00124.1 - 2.3 6.6 4.5 3.2 6.1 4.5 1.2 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor DUF913 PF06025.12 EGE00124.1 - 5.9 5.8 10.2 0.53 9.2 3.1 2.0 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) Adaptin_binding PF10199.9 EGE00124.1 - 8.7 7.0 17.5 5.4e+03 -2.0 17.5 2.2 1 1 0 1 1 1 0 Alpha and gamma adaptin binding protein p34 CLTH PF10607.9 EGE00125.1 - 1.7e-33 115.6 0.0 2.9e-33 114.8 0.0 1.4 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain SPRY PF00622.28 EGE00125.1 - 2.3e-24 85.8 0.2 4e-24 85.0 0.2 1.4 1 0 0 1 1 1 1 SPRY domain LisH PF08513.11 EGE00125.1 - 0.004 17.1 0.5 0.0094 15.9 0.1 1.9 2 0 0 2 2 2 1 LisH Goodbye PF17109.5 EGE00126.1 - 8.9e-37 126.2 0.2 3.6e-36 124.3 0.0 2.1 2 0 0 2 2 2 1 fungal STAND N-terminal Goodbye domain TPR_2 PF07719.17 EGE00126.1 - 4.4e-10 38.9 10.0 0.0086 16.1 0.0 6.0 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_12 PF13424.6 EGE00126.1 - 5.7e-09 36.1 2.5 0.0016 18.7 0.0 4.5 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 EGE00126.1 - 1.9e-08 33.7 4.1 0.0035 17.1 0.0 4.9 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_8 PF13181.6 EGE00126.1 - 4e-07 29.7 0.5 0.1 12.8 0.0 4.9 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_7 PF13176.6 EGE00126.1 - 1.1e-06 28.3 5.5 0.76 9.9 0.0 5.8 5 0 0 5 5 5 2 Tetratricopeptide repeat AAA_16 PF13191.6 EGE00126.1 - 0.00085 19.7 0.0 0.013 15.9 0.0 2.9 2 0 0 2 2 2 1 AAA ATPase domain TPR_19 PF14559.6 EGE00126.1 - 0.0051 17.3 0.0 1.8 9.1 0.0 3.2 2 0 0 2 2 2 1 Tetratricopeptide repeat NACHT PF05729.12 EGE00126.1 - 0.0057 16.6 0.0 0.017 15.1 0.0 1.8 1 0 0 1 1 1 1 NACHT domain TPR_10 PF13374.6 EGE00126.1 - 0.024 14.5 0.6 8.6 6.4 0.1 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF2075 PF09848.9 EGE00126.1 - 0.034 13.4 0.0 0.18 11.0 0.0 1.9 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) TPR_14 PF13428.6 EGE00126.1 - 0.069 14.0 0.2 42 5.3 0.0 4.5 3 1 1 4 4 4 0 Tetratricopeptide repeat Msap1 PF17077.5 EGE00126.1 - 0.091 11.9 1.0 0.14 11.3 0.2 1.6 2 0 0 2 2 2 0 Mitotic spindle associated protein SHE1 TPR_6 PF13174.6 EGE00126.1 - 0.1 13.3 16.0 0.43 11.3 0.4 5.4 6 0 0 6 6 5 0 Tetratricopeptide repeat RPN7 PF10602.9 EGE00126.1 - 0.11 12.1 1.3 0.25 11.1 0.2 2.1 2 0 0 2 2 2 0 26S proteasome subunit RPN7 Glyco_hydro_16 PF00722.21 EGE00127.1 - 2.4e-10 40.1 0.1 3.9e-10 39.5 0.1 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 IDO PF01231.18 EGE00128.1 - 3.9e-34 118.2 0.0 9.3e-34 116.9 0.0 1.4 1 1 0 1 1 1 1 Indoleamine 2,3-dioxygenase TPR_2 PF07719.17 EGE00129.1 - 1.6e-09 37.1 8.3 0.038 14.1 0.4 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_12 PF13424.6 EGE00129.1 - 2.1e-06 27.9 6.1 0.025 14.9 3.1 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat F-box PF00646.33 EGE00129.1 - 3e-06 27.0 0.0 9e-06 25.4 0.0 1.9 1 0 0 1 1 1 1 F-box domain TPR_1 PF00515.28 EGE00129.1 - 1.5e-05 24.6 5.9 0.2 11.5 0.4 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_16 PF13432.6 EGE00129.1 - 0.00032 21.3 8.3 0.12 13.1 3.4 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat F-box-like PF12937.7 EGE00129.1 - 0.0033 17.3 0.0 0.0084 16.0 0.0 1.7 1 0 0 1 1 1 1 F-box-like MIT PF04212.18 EGE00129.1 - 0.0061 16.6 2.4 1.1 9.4 0.1 2.5 2 0 0 2 2 2 2 MIT (microtubule interacting and transport) domain TPR_7 PF13176.6 EGE00129.1 - 0.03 14.4 7.6 2.6 8.3 0.1 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.6 EGE00129.1 - 0.037 13.7 1.3 0.84 9.4 0.0 3.2 2 1 1 3 3 3 0 TPR repeat TPR_14 PF13428.6 EGE00129.1 - 0.12 13.3 11.0 2.4 9.2 0.9 4.4 2 1 2 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.6 EGE00129.1 - 0.15 12.5 6.9 0.71 10.4 0.4 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_10 PF13374.6 EGE00129.1 - 0.18 11.7 5.4 3.7 7.6 0.1 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.6 EGE00129.1 - 1 9.7 5.5 24 5.5 0.1 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_3 PF07720.12 EGE00129.1 - 1.3 9.1 4.6 3.6 7.7 0.1 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_9 PF13371.6 EGE00129.1 - 4.1 7.6 8.2 3 8.1 0.2 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat Glucosamine_iso PF01182.20 EGE00131.1 - 2.4e-68 230.4 0.0 2.7e-68 230.2 0.0 1.0 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase ECH_1 PF00378.20 EGE00132.1 - 0.26 10.6 0.9 0.49 9.6 0.9 1.4 1 0 0 1 1 1 0 Enoyl-CoA hydratase/isomerase FAM76 PF16046.5 EGE00132.1 - 0.32 10.3 5.0 0.65 9.3 5.0 1.4 1 0 0 1 1 1 0 FAM76 protein DUF3484 PF11983.8 EGE00132.1 - 9 7.5 0.0 9 7.5 0.0 3.4 4 1 0 4 4 4 0 Membrane-attachment and polymerisation-promoting switch WD40 PF00400.32 EGE00133.1 - 3.6e-23 81.4 14.7 3e-06 27.8 0.3 6.0 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EGE00133.1 - 0.00019 21.7 0.0 0.016 15.5 0.0 3.5 2 2 2 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain SET PF00856.28 EGE00134.1 - 5.3e-09 36.7 0.0 1.2e-07 32.2 0.0 2.7 2 1 0 2 2 2 1 SET domain zf-MYND PF01753.18 EGE00134.1 - 0.057 13.5 6.0 0.16 12.0 6.0 1.9 1 0 0 1 1 1 0 MYND finger RabGAP-TBC PF00566.18 EGE00137.1 - 2.4e-31 109.1 0.0 1.3e-30 106.6 0.0 1.9 1 1 0 1 1 1 1 Rab-GTPase-TBC domain DUF1455 PF07306.11 EGE00137.1 - 0.24 11.4 1.9 0.58 10.1 1.9 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1455) EF-hand_6 PF13405.6 EGE00138.1 - 3.3e-14 51.5 0.9 6.7e-06 25.6 0.1 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 EGE00138.1 - 1.6e-12 46.0 1.3 2.1e-05 23.8 0.1 2.5 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 EGE00138.1 - 4.8e-10 39.7 0.1 0.00066 20.1 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 EGE00138.1 - 4.3e-08 32.3 3.0 0.0041 16.6 0.4 2.5 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 EGE00138.1 - 1.7e-06 27.8 0.2 0.036 13.9 0.1 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_9 PF14658.6 EGE00138.1 - 0.0025 18.1 0.0 2.7 8.4 0.0 2.5 2 1 0 2 2 2 2 EF-hand domain Afi1 PF07792.12 EGE00139.1 - 1.3e-39 135.7 0.6 2.4e-39 134.8 0.6 1.5 1 0 0 1 1 1 1 Docking domain of Afi1 for Arf3 in vesicle trafficking SPA PF08616.10 EGE00139.1 - 4.8e-37 126.4 0.0 7.9e-37 125.7 0.0 1.4 1 0 0 1 1 1 1 Stabilization of polarity axis Avl9 PF09794.9 EGE00139.1 - 1.6e-07 30.4 0.0 0.048 12.4 0.0 3.5 2 1 1 3 3 3 3 Transport protein Avl9 Formyl_trans_N PF00551.19 EGE00140.1 - 1.8e-38 132.1 0.0 2e-38 131.9 0.0 1.0 1 0 0 1 1 1 1 Formyl transferase Ribosomal_L7Ae PF01248.26 EGE00141.1 - 1.6e-24 85.5 0.0 1.8e-24 85.3 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family RRM_1 PF00076.22 EGE00143.1 - 6.4e-18 64.3 0.0 6e-13 48.4 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 EGE00143.1 - 0.00024 21.1 0.0 0.0081 16.2 0.1 2.4 2 0 0 2 2 2 1 Limkain b1 DUF3915 PF13054.6 EGE00145.1 - 0.043 13.8 1.2 0.043 13.8 1.2 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF3915) MA3 PF02847.17 EGE00146.1 - 1.6e-26 92.5 0.1 4e-26 91.2 0.1 1.7 2 0 0 2 2 2 1 MA3 domain MIF4G PF02854.19 EGE00146.1 - 5.2e-12 45.8 0.1 1.1e-11 44.9 0.1 1.5 1 0 0 1 1 1 1 MIF4G domain DPM2 PF07297.12 EGE00147.1 - 1.1e-14 54.5 0.0 1.3e-14 54.2 0.0 1.1 1 0 0 1 1 1 1 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) DUF4229 PF14012.6 EGE00147.1 - 0.01 15.9 0.1 0.012 15.7 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4229) COX14 PF14880.6 EGE00147.1 - 0.015 15.1 0.1 0.021 14.7 0.1 1.2 1 0 0 1 1 1 0 Cytochrome oxidase c assembly LapA_dom PF06305.11 EGE00147.1 - 0.019 14.8 0.1 0.023 14.5 0.1 1.2 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain PIG-P PF08510.12 EGE00147.1 - 0.11 12.4 0.1 0.11 12.4 0.1 1.1 1 0 0 1 1 1 0 PIG-P HD PF01966.22 EGE00149.1 - 0.00074 19.7 0.1 0.0063 16.7 0.0 2.4 2 1 0 2 2 2 1 HD domain PDEase_I PF00233.19 EGE00149.1 - 0.016 15.0 0.0 0.029 14.1 0.0 1.3 1 0 0 1 1 1 0 3'5'-cyclic nucleotide phosphodiesterase RMI1_C PF16099.5 EGE00149.1 - 0.099 12.5 0.0 0.25 11.2 0.0 1.6 1 0 0 1 1 1 0 Recq-mediated genome instability protein 1, C-terminal OB-fold PPR_1 PF12854.7 EGE00149.1 - 0.26 11.0 0.6 1.7 8.4 0.0 2.3 2 0 0 2 2 2 0 PPR repeat SPX PF03105.19 EGE00150.1 - 3.8 7.3 7.3 4.4 7.1 7.3 1.1 1 0 0 1 1 1 0 SPX domain Arrestin_N PF00339.29 EGE00151.1 - 1.2e-10 41.6 2.1 8.6e-07 29.1 0.0 3.5 4 0 0 4 4 4 2 Arrestin (or S-antigen), N-terminal domain Bul1_C PF04426.12 EGE00151.1 - 0.012 15.0 0.0 0.047 13.1 0.0 1.9 3 0 0 3 3 3 0 Bul1 C terminus IDEAL PF08858.10 EGE00152.1 - 0.49 10.2 2.6 1.2 9.0 2.6 1.6 1 0 0 1 1 1 0 IDEAL domain Pyr_redox_2 PF07992.14 EGE00153.1 - 1.2e-52 179.0 0.4 1.5e-52 178.7 0.4 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EGE00153.1 - 7.5e-18 64.9 0.6 1.2e-14 54.6 0.3 2.6 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Rieske PF00355.26 EGE00153.1 - 3.4e-16 59.0 0.0 7.2e-16 57.9 0.0 1.5 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Reductase_C PF14759.6 EGE00153.1 - 2.1e-06 28.2 0.0 5.1e-06 27.0 0.0 1.6 1 0 0 1 1 1 1 Reductase C-terminal K_oxygenase PF13434.6 EGE00153.1 - 4.4e-06 26.1 0.0 0.067 12.3 0.0 2.4 2 1 1 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 EGE00153.1 - 7.6e-06 26.0 0.2 0.29 11.1 0.0 3.2 3 0 0 3 3 3 2 FAD-NAD(P)-binding Rieske_2 PF13806.6 EGE00153.1 - 0.00015 21.6 0.0 0.00041 20.2 0.0 1.7 1 0 0 1 1 1 1 Rieske-like [2Fe-2S] domain DUF1188 PF06690.11 EGE00153.1 - 0.0014 18.2 0.0 0.0023 17.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1188) NAD_binding_7 PF13241.6 EGE00153.1 - 0.0033 17.8 0.3 0.45 11.0 0.0 2.4 2 0 0 2 2 2 1 Putative NAD(P)-binding HI0933_like PF03486.14 EGE00153.1 - 0.0033 16.2 0.3 2.2 6.9 0.0 2.5 3 0 0 3 3 3 2 HI0933-like protein FIST PF08495.10 EGE00153.1 - 0.013 15.5 0.1 0.061 13.3 0.0 2.0 2 0 0 2 2 2 0 FIST N domain Amino_oxidase PF01593.24 EGE00153.1 - 0.037 13.3 0.0 0.07 12.4 0.0 1.4 1 0 0 1 1 1 0 Flavin containing amine oxidoreductase TrkA_N PF02254.18 EGE00153.1 - 0.094 13.0 0.2 6.9 7.0 0.2 2.7 2 0 0 2 2 2 0 TrkA-N domain SAM_2 PF07647.17 EGE00154.1 - 1.7e-07 31.2 0.1 3.6e-07 30.2 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 EGE00154.1 - 0.0028 18.0 0.1 0.0067 16.9 0.1 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) DUF4508 PF14969.6 EGE00154.1 - 0.037 14.3 0.4 0.13 12.6 0.4 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4508) MerR-DNA-bind PF09278.11 EGE00154.1 - 0.15 12.7 1.1 1.8 9.1 0.6 2.9 2 0 0 2 2 2 0 MerR, DNA binding ADIP PF11559.8 EGE00155.1 - 3.3e-39 134.4 12.4 3.3e-39 134.4 12.4 2.3 3 0 0 3 3 3 1 Afadin- and alpha -actinin-Binding Golgin_A5 PF09787.9 EGE00155.1 - 0.0048 16.4 10.0 0.0048 16.4 10.0 2.3 2 0 0 2 2 2 1 Golgin subfamily A member 5 DUF3450 PF11932.8 EGE00155.1 - 0.036 13.4 9.8 0.13 11.6 9.8 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) DUF724 PF05266.14 EGE00155.1 - 0.34 10.7 9.9 0.25 11.2 6.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF724) TTRAP PF14203.6 EGE00155.1 - 0.35 10.9 2.7 0.49 10.4 0.3 2.4 2 0 0 2 2 2 0 Putative tranposon-transfer assisting protein RasGAP_C PF03836.15 EGE00155.1 - 0.39 10.9 9.7 4.4 7.4 2.0 2.8 1 1 1 2 2 2 0 RasGAP C-terminus HAUS6_N PF14661.6 EGE00155.1 - 0.88 9.1 5.4 2.3 7.7 5.4 1.7 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus KxDL PF10241.9 EGE00155.1 - 1 9.7 10.6 0.17 12.2 5.2 2.4 2 0 0 2 2 2 0 Uncharacterized conserved protein DUF641 PF04859.12 EGE00155.1 - 1.1 9.6 12.0 1.2e+02 3.1 8.7 3.5 2 1 0 2 2 2 0 Plant protein of unknown function (DUF641) TRAF_BIRC3_bd PF16673.5 EGE00155.1 - 2.8 7.8 7.1 0.43 10.4 2.4 2.2 2 0 0 2 2 2 0 TNF receptor-associated factor BIRC3 binding domain Fib_alpha PF08702.10 EGE00155.1 - 4.4 7.5 12.4 1.3 9.2 7.8 2.4 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family PKcGMP_CC PF16808.5 EGE00155.1 - 5.8 6.9 7.4 48 3.9 0.6 3.7 3 0 0 3 3 3 0 Coiled-coil N-terminus of cGMP-dependent protein kinase dUTPase PF00692.19 EGE00156.1 - 2.8e-43 146.7 0.0 3.6e-43 146.3 0.0 1.1 1 0 0 1 1 1 1 dUTPase DCD PF06559.11 EGE00156.1 - 0.15 10.8 0.0 0.21 10.3 0.0 1.1 1 0 0 1 1 1 0 2'-deoxycytidine 5'-triphosphate deaminase (DCD) Phos_pyr_kin PF08543.12 EGE00157.1 - 1.4e-11 44.2 0.0 3e-11 43.2 0.0 1.5 1 1 0 1 1 1 1 Phosphomethylpyrimidine kinase PfkB PF00294.24 EGE00157.1 - 8.1e-08 31.9 0.0 1.8e-07 30.8 0.0 1.6 1 0 0 1 1 1 1 pfkB family carbohydrate kinase BON PF04972.17 EGE00157.1 - 0.069 13.5 1.1 1.1 9.6 0.0 2.5 2 0 0 2 2 2 0 BON domain PQ-loop PF04193.14 EGE00158.1 - 1.7e-32 111.0 18.1 1e-17 63.6 1.3 2.9 3 0 0 3 3 3 2 PQ loop repeat DUF3429 PF11911.8 EGE00158.1 - 0.013 15.8 3.0 0.023 15.0 3.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3429) zf-HC5HC2H_2 PF13832.6 EGE00159.1 - 5.1e-24 84.6 0.7 5.1e-24 84.6 0.7 3.4 4 0 0 4 4 4 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 EGE00159.1 - 2.4e-21 75.8 2.3 2.4e-21 75.8 2.3 3.8 3 1 0 3 3 3 1 PHD-like zinc-binding domain PHD_2 PF13831.6 EGE00159.1 - 2.9e-08 33.1 3.9 2.9e-08 33.1 3.9 3.8 5 0 0 5 5 5 1 PHD-finger PHD PF00628.29 EGE00159.1 - 5.9e-07 29.3 7.7 5.9e-07 29.3 7.7 4.6 5 0 0 5 5 5 2 PHD-finger C1_1 PF00130.22 EGE00159.1 - 0.0068 16.3 2.2 0.0068 16.3 2.2 5.4 5 1 1 6 6 6 1 Phorbol esters/diacylglycerol binding domain (C1 domain) FYVE_2 PF02318.16 EGE00159.1 - 0.0073 16.5 2.4 0.0073 16.5 2.4 3.5 4 0 0 4 4 4 1 FYVE-type zinc finger Myb_DNA-binding PF00249.31 EGE00159.1 - 0.033 14.4 0.3 0.12 12.6 0.0 2.1 2 0 0 2 2 2 0 Myb-like DNA-binding domain C1_2 PF03107.16 EGE00159.1 - 0.042 14.2 0.2 0.042 14.2 0.2 5.5 5 0 0 5 5 5 0 C1 domain GATA PF00320.27 EGE00159.1 - 0.98 9.1 19.5 0.26 11.0 1.0 5.0 4 0 0 4 4 4 0 GATA zinc finger Sin_N PF04801.13 EGE00159.1 - 4.6 6.4 13.3 3.6 6.7 3.0 2.3 2 0 0 2 2 2 0 Sin-like protein conserved region zf-RING-like PF08746.11 EGE00159.1 - 5.3 7.4 24.9 2.1 8.7 9.7 3.3 2 0 0 2 2 2 0 RING-like domain BAH PF01426.18 EGE00160.1 - 1.2e-15 57.4 0.0 1.9e-15 56.8 0.0 1.3 1 0 0 1 1 1 1 BAH domain CDC45 PF02724.14 EGE00161.1 - 0.32 9.2 5.4 0.35 9.1 5.4 1.0 1 0 0 1 1 1 0 CDC45-like protein Cas_Csy4 PF09618.10 EGE00161.1 - 0.35 11.0 4.5 0.45 10.6 4.5 1.1 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Csy4) Presenilin PF01080.17 EGE00161.1 - 4.2 6.0 4.2 4.5 5.9 4.2 1.0 1 0 0 1 1 1 0 Presenilin JAB PF01398.21 EGE00162.1 - 5.2e-14 52.2 0.0 8.4e-14 51.6 0.0 1.3 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Prok-JAB PF14464.6 EGE00162.1 - 1.2e-05 25.1 0.0 2.4e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain TBCC PF07986.12 EGE00163.1 - 3.1e-24 85.0 1.2 5.7e-24 84.2 0.7 1.7 2 0 0 2 2 2 1 Tubulin binding cofactor C TBCC_N PF16752.5 EGE00163.1 - 8.2e-12 45.6 0.1 8.2e-12 45.6 0.1 2.3 2 1 0 2 2 2 1 Tubulin-specific chaperone C N-terminal domain Ndc1_Nup PF09531.10 EGE00163.1 - 0.029 13.1 3.4 0.034 12.9 3.4 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup GCH_III PF05165.12 EGE00163.1 - 0.081 12.2 0.5 0.17 11.1 0.2 1.7 2 0 0 2 2 2 0 GTP cyclohydrolase III DAG_kinase_N PF14513.6 EGE00163.1 - 5.4 7.2 8.4 17 5.5 8.4 1.8 1 1 0 1 1 1 0 Diacylglycerol kinase N-terminus DivIVA PF05103.13 EGE00164.1 - 0.001 19.2 22.5 0.012 15.7 7.8 3.4 2 1 1 3 3 3 2 DivIVA protein HAP1_N PF04849.13 EGE00164.1 - 0.034 13.3 0.4 0.034 13.3 0.4 3.0 2 1 0 2 2 2 0 HAP1 N-terminal conserved region DUF4407 PF14362.6 EGE00164.1 - 3 7.1 19.7 0.014 14.7 5.5 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Fib_alpha PF08702.10 EGE00164.1 - 6 7.0 17.5 1.8 8.8 6.2 3.4 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family PET117 PF15786.5 EGE00165.1 - 2.4e-26 91.8 1.2 2.9e-26 91.5 1.2 1.1 1 0 0 1 1 1 1 PET assembly of cytochrome c oxidase, mitochondrial THEG4 PF15834.5 EGE00165.1 - 0.14 12.1 0.1 0.21 11.6 0.1 1.4 1 1 0 1 1 1 0 Testis highly expressed protein 4 V-ATPase_G PF03179.15 EGE00166.1 - 1.2e-32 112.5 15.7 1.5e-32 112.3 15.7 1.0 1 0 0 1 1 1 1 Vacuolar (H+)-ATPase G subunit ATP-synt_B PF00430.18 EGE00166.1 - 0.0054 16.8 19.0 0.0065 16.6 11.8 2.1 1 1 1 2 2 2 1 ATP synthase B/B' CF(0) V-ATPase_G_2 PF16999.5 EGE00166.1 - 0.0095 16.3 12.9 0.015 15.7 12.9 1.4 1 1 0 1 1 1 1 Vacuolar (H+)-ATPase G subunit DUF1834 PF08873.11 EGE00166.1 - 0.12 12.1 0.7 0.15 11.8 0.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1834) RGS-like PF09128.11 EGE00166.1 - 0.16 11.6 5.4 0.18 11.5 5.4 1.2 1 0 0 1 1 1 0 Regulator of G protein signalling-like domain HypD PF01924.16 EGE00166.1 - 0.22 10.6 1.5 0.26 10.3 1.5 1.1 1 0 0 1 1 1 0 Hydrogenase formation hypA family OmpH PF03938.14 EGE00166.1 - 0.24 11.8 16.1 0.26 11.6 16.1 1.1 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Tai4 PF16695.5 EGE00166.1 - 0.29 11.7 4.4 0.56 10.8 0.3 2.1 1 1 1 2 2 2 0 Type VI secretion system (T6SS), amidase immunity protein DUF3552 PF12072.8 EGE00166.1 - 0.43 10.0 19.6 0.89 8.9 19.6 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF3552) ATP11 PF06644.11 EGE00166.1 - 1.4 8.7 11.1 1.7 8.4 11.1 1.0 1 0 0 1 1 1 0 ATP11 protein SAPS PF04499.15 EGE00166.1 - 1.8 7.3 9.1 2 7.1 9.1 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein DUF676 PF05057.14 EGE00167.1 - 0.084 12.4 0.0 0.3 10.6 0.0 1.8 1 1 0 1 1 1 0 Putative serine esterase (DUF676) Helicase_C PF00271.31 EGE00168.1 - 2.3e-20 73.0 0.1 6.1e-20 71.6 0.1 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EGE00168.1 - 5e-20 72.2 0.0 9.7e-20 71.2 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EGE00168.1 - 4.5e-15 55.9 0.0 1.3e-14 54.4 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase ERCC3_RAD25_C PF16203.5 EGE00168.1 - 0.0048 16.1 0.0 0.009 15.3 0.0 1.3 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase SWI2_SNF2 PF18766.1 EGE00168.1 - 0.0069 16.1 0.0 0.014 15.1 0.0 1.4 1 0 0 1 1 1 1 SWI2/SNF2 ATPase F_actin_cap_B PF01115.17 EGE00169.1 - 7.2e-106 353.2 0.0 8.3e-106 353.0 0.0 1.0 1 0 0 1 1 1 1 F-actin capping protein, beta subunit Med11 PF10280.9 EGE00170.1 - 2.3e-41 141.5 0.1 3e-41 141.1 0.1 1.2 1 0 0 1 1 1 1 Mediator complex protein DUF5344 PF17279.2 EGE00170.1 - 0.0022 18.5 0.1 0.0049 17.4 0.1 1.6 1 1 0 1 1 1 1 Family of unknown function (DUF5344) WD40 PF00400.32 EGE00171.1 - 3.5e-48 160.6 27.5 9.1e-09 35.8 0.4 6.7 6 0 0 6 6 6 6 WD domain, G-beta repeat TFIID_NTD2 PF04494.15 EGE00171.1 - 2.8e-35 121.4 0.1 4e-35 120.9 0.1 1.2 1 0 0 1 1 1 1 WD40 associated region in TFIID subunit, NTD2 domain ANAPC4_WD40 PF12894.7 EGE00171.1 - 3.4e-14 52.9 1.0 0.015 15.6 0.0 5.3 2 1 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain LisH PF08513.11 EGE00171.1 - 1.5e-07 31.1 0.0 4.2e-07 29.7 0.0 1.8 1 0 0 1 1 1 1 LisH Nup160 PF11715.8 EGE00171.1 - 6.1e-07 28.5 1.7 0.00014 20.7 0.2 3.7 3 1 1 4 4 4 1 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 EGE00171.1 - 0.00079 18.5 0.3 0.063 12.2 0.0 3.1 3 1 1 4 4 4 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Nucleoporin_N PF08801.11 EGE00171.1 - 0.0024 16.7 0.1 3 6.5 0.0 3.2 2 1 1 3 3 3 2 Nup133 N terminal like eIF2A PF08662.11 EGE00171.1 - 0.018 14.9 0.3 0.071 13.0 0.1 2.0 2 0 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A DUF4550 PF15084.6 EGE00171.1 - 0.077 13.4 0.0 0.3 11.5 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4550) PALB2_WD40 PF16756.5 EGE00171.1 - 5.2 5.9 5.4 0.77 8.6 0.8 1.9 2 0 0 2 2 2 0 Partner and localizer of BRCA2 WD40 domain Abhydrolase_6 PF12697.7 EGE00172.1 - 1e-23 85.1 0.3 1.3e-23 84.7 0.3 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EGE00172.1 - 1.1e-09 38.4 0.0 1.6e-09 37.8 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EGE00172.1 - 1.3e-05 24.6 0.0 2.4e-05 23.7 0.0 1.5 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Thioesterase PF00975.20 EGE00172.1 - 0.072 13.2 0.1 0.37 10.8 0.1 2.0 1 1 0 1 1 1 0 Thioesterase domain Abhydrolase_5 PF12695.7 EGE00172.1 - 0.083 12.7 0.0 0.15 11.8 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family Lipase_3 PF01764.25 EGE00172.1 - 0.16 11.8 0.0 0.29 11.0 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) DUF2417 PF10329.9 EGE00173.1 - 1.4e-80 270.1 0.4 2e-80 269.7 0.4 1.2 1 0 0 1 1 1 1 Region of unknown function (DUF2417) Pox_A9 PF04835.12 EGE00173.1 - 0.023 14.8 2.0 3.9 7.7 0.1 2.6 2 0 0 2 2 2 0 A9 protein conserved region Trp_oprn_chp PF09534.10 EGE00173.1 - 0.46 10.3 6.2 0.057 13.2 0.7 2.2 3 0 0 3 3 3 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) PMSR PF01625.21 EGE00174.1 - 1.6e-60 203.7 0.7 1.9e-60 203.5 0.7 1.0 1 0 0 1 1 1 1 Peptide methionine sulfoxide reductase Pro_dh PF01619.18 EGE00176.1 - 2.1e-61 208.0 0.0 3.2e-61 207.5 0.0 1.3 1 0 0 1 1 1 1 Proline dehydrogenase GFA PF04828.14 EGE00177.1 - 0.045 14.1 1.2 0.11 12.9 1.2 1.7 1 1 0 1 1 1 0 Glutathione-dependent formaldehyde-activating enzyme Glyco_hydro_16 PF00722.21 EGE00178.1 - 4.3e-44 150.1 1.7 6.3e-44 149.5 1.7 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 Alk_phosphatase PF00245.20 EGE00179.1 - 1.8e-108 363.2 0.0 2.2e-108 362.9 0.0 1.1 1 0 0 1 1 1 1 Alkaline phosphatase Metalloenzyme PF01676.18 EGE00179.1 - 8.2e-05 22.1 0.0 0.00018 21.0 0.0 1.5 1 0 0 1 1 1 1 Metalloenzyme superfamily DUF498 PF04430.14 EGE00180.1 - 1.6e-31 108.6 0.0 2.3e-31 108.1 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF498/DUF598) ABC_membrane PF00664.23 EGE00181.1 - 1.5e-34 120.0 8.5 1.5e-34 120.0 8.5 1.8 2 0 0 2 2 2 1 ABC transporter transmembrane region ABC_tran PF00005.27 EGE00181.1 - 1.9e-33 115.9 0.0 4.5e-33 114.7 0.0 1.7 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 EGE00181.1 - 6.6e-08 32.2 0.1 1.8e-05 24.3 0.0 2.9 2 1 1 3 3 3 1 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 EGE00181.1 - 0.013 15.8 0.0 0.068 13.4 0.0 2.0 2 0 0 2 2 2 0 AAA domain SbcCD_C PF13558.6 EGE00181.1 - 0.016 15.4 0.5 0.44 10.8 0.5 2.7 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_16 PF13191.6 EGE00181.1 - 0.045 14.1 0.9 0.25 11.7 0.9 2.2 1 1 0 1 1 1 0 AAA ATPase domain AAA_29 PF13555.6 EGE00181.1 - 0.048 13.4 0.2 0.11 12.2 0.2 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EGE00181.1 - 0.051 13.5 0.0 0.1 12.5 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase Afi1 PF07792.12 EGE00182.1 - 4.9 7.7 14.5 6 7.4 1.3 2.2 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking DUF1168 PF06658.12 EGE00182.1 - 7.1 6.5 28.3 3.8 7.3 10.8 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1168) WD40 PF00400.32 EGE00183.1 - 2e-14 53.7 12.3 6.5e-06 26.8 0.4 6.5 7 0 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EGE00183.1 - 1.3e-06 28.6 0.1 1.1 9.6 0.0 4.3 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EGE00183.1 - 0.0061 16.5 0.0 0.09 12.6 0.0 2.5 2 1 1 3 3 3 1 Eukaryotic translation initiation factor eIF2A Zn_ribbon_17 PF17120.5 EGE00183.1 - 0.0068 16.0 7.7 0.02 14.5 7.7 1.7 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type PD40 PF07676.12 EGE00183.1 - 0.06 13.3 1.0 0.33 10.9 0.1 2.8 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat zinc_ribbon_16 PF17034.5 EGE00183.1 - 0.82 9.9 8.4 1.1 9.5 0.6 2.5 2 0 0 2 2 2 0 Zinc-ribbon like family Forkhead PF00250.18 EGE00184.1 - 6.3e-20 71.2 0.2 1.4e-19 70.2 0.2 1.6 1 0 0 1 1 1 1 Forkhead domain Cactin_mid PF10312.9 EGE00185.1 - 4.8e-66 222.3 4.8 4.8e-66 222.3 4.8 1.6 2 0 0 2 2 2 1 Conserved mid region of cactin CactinC_cactus PF09732.9 EGE00185.1 - 7.8e-57 190.6 6.2 1.3e-56 189.9 6.2 1.4 1 0 0 1 1 1 1 Cactus-binding C-terminus of cactin protein Pox_VLTF3 PF04947.14 EGE00185.1 - 0.15 11.8 0.9 0.54 10.0 0.1 2.1 2 0 0 2 2 2 0 Poxvirus Late Transcription Factor VLTF3 like XLF PF09302.11 EGE00186.1 - 1.3e-53 181.9 0.1 1.3e-53 181.9 0.1 1.6 2 0 0 2 2 2 1 XLF-Cernunnos, XRcc4-like factor, NHEJ component Ribosomal_L34e PF01199.18 EGE00187.1 - 4.4e-43 145.5 2.9 6.6e-43 144.9 2.9 1.3 1 0 0 1 1 1 1 Ribosomal protein L34e Vps36-NZF-N PF16988.5 EGE00187.1 - 0.031 13.7 1.4 0.041 13.3 0.0 2.0 2 0 0 2 2 2 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain FhuF_C PF11575.8 EGE00187.1 - 0.66 10.0 5.1 3.5 7.7 0.3 2.6 2 0 0 2 2 2 0 FhuF 2Fe-2S C-terminal domain PROCN PF08083.11 EGE00188.1 - 3.9e-205 681.2 17.8 1.1e-133 445.9 4.0 3.0 2 1 1 3 3 3 2 PROCN (NUC071) domain PRP8_domainIV PF12134.8 EGE00188.1 - 1.3e-126 420.9 2.6 2.2e-126 420.1 2.6 1.4 1 0 0 1 1 1 1 PRP8 domain IV core U6-snRNA_bdg PF10596.9 EGE00188.1 - 5.2e-84 280.0 2.1 1.8e-57 193.8 0.3 3.1 2 0 0 2 2 2 2 U6-snRNA interacting domain of PrP8 PRO8NT PF08082.11 EGE00188.1 - 8.9e-81 269.2 1.8 2.5e-80 267.7 1.8 1.9 1 0 0 1 1 1 1 PRO8NT (NUC069), PrP8 N-terminal domain U5_2-snRNA_bdg PF10597.9 EGE00188.1 - 1.5e-70 235.5 0.1 3.2e-70 234.4 0.1 1.6 1 0 0 1 1 1 1 U5-snRNA binding site 2 of PrP8 PROCT PF08084.11 EGE00188.1 - 9.5e-49 164.4 0.1 3.1e-48 162.8 0.1 1.9 1 0 0 1 1 1 1 PROCT (NUC072) domain RRM_4 PF10598.9 EGE00188.1 - 3.5e-48 161.9 0.3 9.4e-48 160.5 0.3 1.8 1 0 0 1 1 1 1 RNA recognition motif of the spliceosomal PrP8 Hom_end_hint PF05203.16 EGE00188.1 - 5.3e-08 33.1 0.0 5.3e-08 33.1 0.0 2.0 2 0 0 2 2 2 1 Hom_end-associated Hint Hom_end PF05204.14 EGE00188.1 - 0.0069 16.5 0.0 0.022 14.9 0.0 1.9 1 0 0 1 1 1 1 Homing endonuclease YflT PF11181.8 EGE00188.1 - 1.5 9.4 3.2 8.1 7.0 1.4 2.8 2 0 0 2 2 2 0 Heat induced stress protein YflT CTP_synth_N PF06418.14 EGE00190.1 - 1e-104 349.6 0.0 1.3e-104 349.2 0.0 1.1 1 0 0 1 1 1 1 CTP synthase N-terminus GATase PF00117.28 EGE00190.1 - 1.9e-55 187.6 0.0 3e-55 187.0 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 EGE00190.1 - 8.3e-06 25.7 0.1 0.02 14.7 0.0 2.4 2 0 0 2 2 2 2 Peptidase C26 Myb_DNA-bind_6 PF13921.6 EGE00192.1 - 1.7e-07 31.4 0.0 3.7e-07 30.3 0.0 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 EGE00192.1 - 0.00012 22.2 0.0 0.0002 21.5 0.0 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain COX5B PF01215.19 EGE00194.1 - 4.4e-55 184.9 0.0 5.9e-55 184.4 0.0 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit Vb zf-C4_Topoisom PF01396.19 EGE00194.1 - 0.082 12.7 0.1 0.92 9.3 0.0 2.1 2 0 0 2 2 2 0 Topoisomerase DNA binding C4 zinc finger Myb_DNA-binding PF00249.31 EGE00197.1 - 2.8e-15 56.2 3.0 5e-09 36.2 0.6 2.3 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EGE00197.1 - 1.3e-09 38.1 1.0 3.6e-06 27.1 0.2 2.5 1 1 1 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 EGE00197.1 - 0.049 13.5 0.8 0.12 12.3 0.8 1.7 1 0 0 1 1 1 0 Myb DNA-binding like Myb_DNA-binding PF00249.31 EGE00199.1 - 0.00016 21.8 0.0 0.00028 21.0 0.0 1.3 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_4 PF13837.6 EGE00203.1 - 0.0083 16.5 3.0 0.026 14.9 0.7 2.4 1 1 1 2 2 2 1 Myb/SANT-like DNA-binding domain PXPV PF12778.7 EGE00203.1 - 0.16 11.8 1.4 0.29 11.0 1.4 1.3 1 0 0 1 1 1 0 PXPV repeat (3 copies) Myb_DNA-bind_6 PF13921.6 EGE00203.1 - 4.2 7.7 7.0 3.9 7.8 2.9 2.3 2 0 0 2 2 2 0 Myb-like DNA-binding domain eRF1_3 PF03465.15 EGE00204.1 - 8e-18 65.0 0.0 1.3e-17 64.3 0.0 1.3 1 0 0 1 1 1 1 eRF1 domain 3 eRF1_2 PF03464.15 EGE00204.1 - 1.2e-16 61.2 0.0 3.4e-16 59.8 0.0 1.7 1 1 0 1 1 1 1 eRF1 domain 2 ATP_bind_1 PF03029.17 EGE00205.1 - 1e-40 140.0 0.2 1.2e-40 139.8 0.2 1.0 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein S-AdoMet_synt_C PF02773.16 EGE00206.1 - 7.3e-67 223.6 1.3 4.9e-66 220.9 0.1 2.1 2 0 0 2 2 2 1 S-adenosylmethionine synthetase, C-terminal domain S-AdoMet_synt_M PF02772.16 EGE00206.1 - 1.8e-46 157.3 0.0 2.9e-46 156.6 0.0 1.3 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, central domain S-AdoMet_synt_N PF00438.20 EGE00206.1 - 2.6e-14 53.7 0.3 1.1e-13 51.6 0.0 2.1 2 0 0 2 2 2 1 S-adenosylmethionine synthetase, N-terminal domain SLD3 PF08639.10 EGE00207.1 - 3.7e-151 504.6 10.6 3.7e-151 504.6 10.6 1.6 2 0 0 2 2 2 1 DNA replication regulator SLD3 CRC_subunit PF08624.10 EGE00209.1 - 1.2e-51 174.7 0.2 1.9e-51 174.1 0.2 1.3 1 0 0 1 1 1 1 Chromatin remodelling complex Rsc7/Swp82 subunit AT_hook PF02178.19 EGE00209.1 - 0.9 9.6 6.9 3.3 7.9 6.3 2.4 1 1 0 1 1 1 0 AT hook motif APH PF01636.23 EGE00210.1 - 1.1e-12 48.5 0.2 1.4e-12 48.0 0.2 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EGE00210.1 - 0.0046 16.6 0.0 0.0066 16.0 0.0 1.2 1 0 0 1 1 1 1 Choline/ethanolamine kinase DUF1679 PF07914.11 EGE00210.1 - 0.03 13.2 0.0 0.039 12.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1679) EcKinase PF02958.20 EGE00210.1 - 0.21 10.8 0.0 0.32 10.2 0.0 1.2 1 0 0 1 1 1 0 Ecdysteroid kinase Homeodomain PF00046.29 EGE00212.1 - 1.5e-16 60.0 1.5 1.5e-15 56.8 2.7 2.0 2 0 0 2 2 2 1 Homeodomain Homeobox_KN PF05920.11 EGE00212.1 - 0.00052 19.8 1.1 0.0013 18.6 1.1 1.7 1 0 0 1 1 1 1 Homeobox KN domain DUF4638 PF15472.6 EGE00212.1 - 0.0094 15.7 2.6 0.015 15.0 2.6 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4638) SDP_N PF12278.8 EGE00212.1 - 3.4 7.8 10.3 8 6.6 10.3 1.6 1 0 0 1 1 1 0 Sex determination protein N terminal MCM_bind PF09739.9 EGE00212.1 - 4 5.8 10.6 6.4 5.1 10.6 1.2 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor HAD_2 PF13419.6 EGE00215.1 - 2.4e-20 73.4 0.0 3.2e-20 73.0 0.0 1.2 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EGE00215.1 - 6.5e-10 39.7 0.2 5.9e-06 26.7 0.0 2.8 2 1 0 3 3 3 2 haloacid dehalogenase-like hydrolase HAD PF12710.7 EGE00215.1 - 7e-05 23.3 0.0 0.00011 22.7 0.0 1.3 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EGE00215.1 - 0.0012 18.8 0.1 0.0031 17.5 0.0 1.7 2 0 0 2 2 2 1 HAD-hyrolase-like Hydrolase_6 PF13344.6 EGE00215.1 - 0.0023 18.0 0.2 0.087 12.9 0.1 2.8 2 1 0 2 2 2 1 Haloacid dehalogenase-like hydrolase GN3L_Grn1 PF08701.11 EGE00216.1 - 1.1e-24 86.3 16.8 2.7e-24 85.0 16.8 1.7 1 0 0 1 1 1 1 GNL3L/Grn1 putative GTPase MMR_HSR1 PF01926.23 EGE00216.1 - 3.8e-18 65.6 0.3 5.5e-13 49.0 0.0 2.5 2 0 0 2 2 2 2 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EGE00216.1 - 4.9e-07 29.8 0.1 2.6e-06 27.4 0.1 2.0 1 1 0 1 1 1 1 RsgA GTPase FeoB_N PF02421.18 EGE00216.1 - 6.9e-06 25.7 0.1 5.3e-05 22.8 0.0 2.1 2 0 0 2 2 2 1 Ferrous iron transport protein B Dynamin_N PF00350.23 EGE00216.1 - 0.00012 22.2 6.2 0.68 10.0 0.2 3.9 2 2 0 3 3 3 2 Dynamin family GTP_EFTU PF00009.27 EGE00216.1 - 0.00057 19.5 0.4 0.54 9.8 0.2 3.3 2 2 0 2 2 2 2 Elongation factor Tu GTP binding domain AIG1 PF04548.16 EGE00216.1 - 0.015 14.6 0.3 0.057 12.7 0.1 1.9 2 0 0 2 2 2 0 AIG1 family cobW PF02492.19 EGE00216.1 - 0.019 14.6 0.1 0.68 9.5 0.0 2.8 2 1 1 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain MeaB PF03308.16 EGE00216.1 - 0.02 13.9 0.1 0.044 12.7 0.1 1.5 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_18 PF13238.6 EGE00216.1 - 0.082 13.5 0.4 0.48 11.0 0.0 2.3 2 0 0 2 2 2 0 AAA domain Roc PF08477.13 EGE00216.1 - 0.086 13.1 0.0 9.8 6.4 0.0 2.4 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_16 PF13191.6 EGE00216.1 - 0.41 11.0 0.0 0.41 11.0 0.0 3.0 2 1 0 2 2 1 0 AAA ATPase domain CBFD_NFYB_HMF PF00808.23 EGE00217.1 - 5.9e-06 26.5 0.0 9.6e-06 25.8 0.0 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone HNF-1_N PF04814.13 EGE00217.1 - 0.22 12.1 8.3 0.36 11.4 8.3 1.4 1 0 0 1 1 1 0 Hepatocyte nuclear factor 1 (HNF-1), N terminus SIR2 PF02146.17 EGE00218.1 - 3e-26 92.4 0.0 1.2e-25 90.5 0.0 1.9 1 1 0 1 1 1 1 Sir2 family Med16 PF11635.8 EGE00219.1 - 3.7e-167 557.6 0.0 4.4e-167 557.3 0.0 1.0 1 0 0 1 1 1 1 Mediator complex subunit 16 ANAPC4_WD40 PF12894.7 EGE00219.1 - 0.0086 16.4 0.0 2.6 8.4 0.0 2.6 2 0 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Ribosomal_L29 PF00831.23 EGE00220.1 - 9.2e-18 64.0 0.2 9.2e-18 64.0 0.2 2.1 2 0 0 2 2 2 1 Ribosomal L29 protein Phe_tRNA-synt_N PF02912.18 EGE00220.1 - 0.056 13.4 0.1 0.056 13.4 0.1 2.3 2 0 0 2 2 2 0 Aminoacyl tRNA synthetase class II, N-terminal domain Cortex-I_coil PF09304.10 EGE00220.1 - 0.27 11.4 5.5 0.33 11.2 1.3 2.1 1 1 0 2 2 2 0 Cortexillin I, coiled coil CorA PF01544.18 EGE00220.1 - 0.38 10.0 2.3 0.47 9.7 2.3 1.2 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein V-SNARE_C PF12352.8 EGE00221.1 - 1.1e-15 57.6 8.0 3.4e-15 56.1 0.1 3.2 3 0 0 3 3 3 1 Snare region anchored in the vesicle membrane C-terminus GOLGA2L5 PF15070.6 EGE00221.1 - 0.0041 15.8 4.2 0.0048 15.6 4.2 1.3 1 0 0 1 1 1 1 Putative golgin subfamily A member 2-like protein 5 AAA_13 PF13166.6 EGE00221.1 - 0.0099 14.6 1.8 0.012 14.3 1.8 1.1 1 0 0 1 1 1 1 AAA domain Phage_GPO PF05929.11 EGE00221.1 - 0.024 14.3 2.5 0.032 13.9 2.5 1.2 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase NleF_casp_inhib PF16809.5 EGE00221.1 - 0.037 13.9 1.5 0.13 12.2 1.1 1.8 1 1 1 2 2 2 0 NleF caspase inhibitor Sec20 PF03908.13 EGE00221.1 - 0.048 13.6 4.9 6 6.9 0.0 3.1 2 1 0 3 3 3 0 Sec20 BLOC1_2 PF10046.9 EGE00221.1 - 0.055 13.8 3.6 0.99 9.7 0.2 2.7 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DivIC PF04977.15 EGE00221.1 - 0.085 12.6 7.7 0.96 9.3 0.9 3.3 2 1 1 3 3 3 0 Septum formation initiator Uso1_p115_C PF04871.13 EGE00221.1 - 0.14 12.5 8.1 0.45 10.9 3.8 2.1 1 1 2 3 3 3 0 Uso1 / p115 like vesicle tethering protein, C terminal region Syntaxin-6_N PF09177.11 EGE00221.1 - 0.25 11.9 6.1 0.52 10.9 5.5 1.9 1 1 1 2 2 2 0 Syntaxin 6, N-terminal FapA PF03961.13 EGE00221.1 - 0.85 8.2 3.7 0.85 8.2 2.6 1.4 1 1 0 1 1 1 0 Flagellar Assembly Protein A APG6_N PF17675.1 EGE00221.1 - 1.5 9.4 11.5 13 6.4 11.0 2.3 1 1 1 2 2 2 0 Apg6 coiled-coil region SATase_N PF06426.14 EGE00221.1 - 2.4 8.6 5.5 27 5.2 5.5 2.5 1 1 0 1 1 1 0 Serine acetyltransferase, N-terminal ATP-synt_10 PF05176.14 EGE00222.1 - 5e-76 255.3 0.0 6.7e-76 254.9 0.0 1.1 1 0 0 1 1 1 1 ATP10 protein DNA_pol_B_palm PF14792.6 EGE00223.1 - 3.1e-33 114.4 0.0 6.1e-33 113.4 0.0 1.5 1 0 0 1 1 1 1 DNA polymerase beta palm DNA_pol_B_thumb PF14791.6 EGE00223.1 - 1.2e-22 79.8 0.0 2.6e-22 78.7 0.0 1.6 1 0 0 1 1 1 1 DNA polymerase beta thumb DNA_pol_lambd_f PF10391.9 EGE00223.1 - 1.4e-19 69.6 0.6 5.2e-19 67.8 0.3 2.2 2 0 0 2 2 2 1 Fingers domain of DNA polymerase lambda HHH_8 PF14716.6 EGE00223.1 - 5e-17 62.0 1.0 1.2e-16 60.9 1.0 1.7 1 0 0 1 1 1 1 Helix-hairpin-helix domain NTP_transf_2 PF01909.23 EGE00223.1 - 0.009 16.3 0.0 0.022 15.1 0.0 1.6 1 0 0 1 1 1 1 Nucleotidyltransferase domain HHH_5 PF14520.6 EGE00223.1 - 0.052 14.2 0.1 19 5.9 0.0 2.6 2 0 0 2 2 2 0 Helix-hairpin-helix domain Zn_clus PF00172.18 EGE00224.1 - 0.0055 16.8 9.3 0.013 15.6 9.3 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain ACOX PF01756.19 EGE00225.1 - 0.041 13.4 0.0 0.099 12.2 0.0 1.6 1 0 0 1 1 1 0 Acyl-CoA oxidase CPL PF08144.11 EGE00226.1 - 3.4e-34 118.2 0.0 2.8e-29 102.3 0.0 3.8 4 0 0 4 4 4 2 CPL (NUC119) domain RRN3 PF05327.11 EGE00226.1 - 0.039 12.5 13.4 1.3 7.5 11.3 2.2 2 0 0 2 2 2 0 RNA polymerase I specific transcription initiation factor RRN3 LAP1C PF05609.12 EGE00226.1 - 0.11 11.6 10.0 0.16 11.1 10.0 1.2 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) DUF2457 PF10446.9 EGE00226.1 - 0.11 11.6 19.0 0.18 10.9 19.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) CDC45 PF02724.14 EGE00226.1 - 0.12 10.6 19.3 0.21 9.9 19.3 1.3 1 0 0 1 1 1 0 CDC45-like protein Nop14 PF04147.12 EGE00226.1 - 0.43 8.7 25.9 0.68 8.1 25.9 1.2 1 0 0 1 1 1 0 Nop14-like family Sigma70_ner PF04546.13 EGE00226.1 - 0.58 10.0 15.5 1.6 8.6 15.5 1.8 1 0 0 1 1 1 0 Sigma-70, non-essential region PI3K_1B_p101 PF10486.9 EGE00226.1 - 1.1 6.9 8.4 1.9 6.2 8.4 1.3 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit NOA36 PF06524.12 EGE00226.1 - 5 6.4 20.4 9.2 5.5 20.4 1.4 1 0 0 1 1 1 0 NOA36 protein Rad51 PF08423.11 EGE00229.1 - 2e-128 427.0 0.0 2.5e-128 426.7 0.0 1.1 1 0 0 1 1 1 1 Rad51 AAA_25 PF13481.6 EGE00229.1 - 1.2e-09 38.0 0.0 1.9e-09 37.4 0.0 1.2 1 0 0 1 1 1 1 AAA domain RecA PF00154.21 EGE00229.1 - 5.5e-08 32.6 0.0 7.5e-08 32.1 0.0 1.2 1 0 0 1 1 1 1 recA bacterial DNA recombination protein HHH_5 PF14520.6 EGE00229.1 - 2.5e-05 24.8 1.1 6.2e-05 23.5 0.5 2.0 2 0 0 2 2 2 1 Helix-hairpin-helix domain ATPase PF06745.13 EGE00229.1 - 0.00012 21.6 0.7 0.00054 19.4 0.7 2.0 1 1 0 1 1 1 1 KaiC DnaB_C PF03796.15 EGE00229.1 - 0.0085 15.5 0.1 0.04 13.2 0.0 1.9 2 0 0 2 2 2 1 DnaB-like helicase C terminal domain HHH PF00633.23 EGE00229.1 - 0.021 14.7 0.4 11 6.1 0.1 2.7 2 0 0 2 2 2 0 Helix-hairpin-helix motif ssDNA_TraI_N PF18272.1 EGE00229.1 - 0.043 13.8 0.7 0.21 11.6 0.1 2.3 3 0 0 3 3 3 0 single-stranded DNA binding TraI N-terminal subdomain PAXNEB PF05625.11 EGE00229.1 - 0.091 11.9 0.2 0.33 10.0 0.0 1.8 2 0 0 2 2 2 0 PAXNEB protein Nup160 PF11715.8 EGE00230.1 - 3.5e-133 445.1 7.1 4.9e-133 444.6 7.1 1.2 1 0 0 1 1 1 1 Nucleoporin Nup120/160 TPR_12 PF13424.6 EGE00230.1 - 0.17 12.2 0.4 1 9.7 0.1 2.5 3 0 0 3 3 3 0 Tetratricopeptide repeat MFS_1 PF07690.16 EGE00231.1 - 4.5e-38 131.1 29.8 4.5e-38 131.1 29.8 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EGE00231.1 - 5.1e-07 28.9 6.9 5.1e-07 28.9 6.9 2.9 3 1 0 3 3 3 1 Sugar (and other) transporter TRI12 PF06609.13 EGE00231.1 - 5.3e-06 25.2 2.5 5.3e-06 25.2 2.5 1.6 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Phage_holin_2_3 PF16080.5 EGE00231.1 - 0.045 13.5 0.1 0.22 11.3 0.1 2.3 1 0 0 1 1 1 0 Bacteriophage holin family HP1 DUF3808 PF10300.9 EGE00232.1 - 3e-145 484.6 0.0 3.7e-145 484.3 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3808) CIDR1_gamma PF18562.1 EGE00232.1 - 0.012 15.7 0.0 0.034 14.2 0.0 1.7 1 0 0 1 1 1 0 Cysteine-Rich Interdomain Region 1 gamma DSS1_SEM1 PF05160.13 EGE00233.1 - 2.1e-21 75.7 13.8 2.7e-21 75.4 13.8 1.1 1 0 0 1 1 1 1 DSS1/SEM1 family DUF2947 PF11163.8 EGE00233.1 - 0.11 12.4 2.6 0.12 12.2 2.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2947) PGK PF00162.19 EGE00234.1 - 6.9e-149 495.9 0.3 7.8e-149 495.7 0.3 1.0 1 0 0 1 1 1 1 Phosphoglycerate kinase PA PF02225.22 EGE00234.1 - 0.0012 18.9 0.6 0.035 14.1 0.0 3.0 3 0 0 3 3 3 1 PA domain zf-C2H2 PF00096.26 EGE00235.1 - 1e-08 35.1 6.0 1.2e-05 25.5 0.5 3.6 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EGE00235.1 - 2.3e-08 34.1 8.4 7.6e-07 29.3 0.7 3.4 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_6 PF13912.6 EGE00235.1 - 4e-07 29.9 0.9 0.017 15.1 0.0 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_4 PF13894.6 EGE00235.1 - 2.9e-05 24.5 6.8 0.002 18.8 0.4 3.6 3 0 0 3 3 3 1 C2H2-type zinc finger FOXP-CC PF16159.5 EGE00235.1 - 0.00014 22.4 10.1 0.083 13.5 0.1 3.7 2 1 2 4 4 4 2 FOXP coiled-coil domain zf-C2H2_11 PF16622.5 EGE00235.1 - 0.046 13.5 1.1 0.092 12.5 0.1 1.9 2 0 0 2 2 2 0 zinc-finger C2H2-type zf-H2C2_5 PF13909.6 EGE00235.1 - 0.14 12.0 3.8 0.32 10.8 0.3 2.6 2 0 0 2 2 2 0 C2H2-type zinc-finger domain zf-C2H2_jaz PF12171.8 EGE00235.1 - 0.19 12.1 3.1 2.7 8.4 0.2 3.4 3 1 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.12 EGE00235.1 - 0.23 11.8 3.5 1.4 9.2 0.5 2.4 1 1 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding Zap1_zf2 PF18217.1 EGE00235.1 - 0.57 10.2 6.9 3.1 7.9 0.7 2.6 2 0 0 2 2 2 0 Zap1 zinc finger 2 zf_ZIC PF18366.1 EGE00235.1 - 0.6 10.3 3.4 1 9.5 0.1 2.9 3 0 0 3 3 3 0 Zic proteins zinc finger domain SNF2_N PF00176.23 EGE00236.1 - 3.7e-56 190.3 0.1 1.1e-55 188.7 0.0 1.7 2 0 0 2 2 2 1 SNF2 family N-terminal domain Chromo PF00385.24 EGE00236.1 - 1.2e-24 85.9 0.4 1.6e-15 56.7 0.1 2.8 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain DUF4208 PF13907.6 EGE00236.1 - 3.3e-21 75.5 0.0 3e-20 72.4 0.0 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF4208) Helicase_C PF00271.31 EGE00236.1 - 6.5e-18 65.1 0.0 2.2e-17 63.4 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Cdh1_DBD_1 PF18196.1 EGE00236.1 - 1.9e-06 28.2 6.9 4.6e-06 26.9 2.1 4.2 4 1 1 5 5 4 2 Chromodomain helicase DNA-binding domain 1 HDA2-3 PF11496.8 EGE00236.1 - 3.1e-06 26.6 0.0 1e-05 24.9 0.0 1.9 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 ResIII PF04851.15 EGE00236.1 - 1.3e-05 25.3 0.2 0.00017 21.7 0.0 2.8 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit CHDCT2 PF08074.11 EGE00236.1 - 0.023 14.9 0.2 0.23 11.6 0.0 2.8 3 0 0 3 3 3 0 CHDCT2 (NUC038) domain SLIDE PF09111.10 EGE00236.1 - 0.049 13.7 0.0 0.53 10.3 0.0 2.8 1 1 1 2 2 2 0 SLIDE AAA_22 PF13401.6 EGE00236.1 - 0.059 13.6 0.0 0.28 11.5 0.0 2.2 1 0 0 1 1 1 0 AAA domain CDH1_2_SANT_HL1 PF18375.1 EGE00236.1 - 0.093 13.4 1.3 0.63 10.7 1.1 2.6 2 0 0 2 2 2 0 CDH1/2 SANT-Helical linker 1 DUF2514 PF10721.9 EGE00236.1 - 0.36 10.8 4.1 1.9 8.5 4.1 2.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2514) ABC_tran PF00005.27 EGE00237.1 - 6.1e-35 120.7 0.0 1.7e-15 57.7 0.0 3.3 3 0 0 3 3 3 2 ABC transporter SMC_N PF02463.19 EGE00237.1 - 3.3e-11 43.1 2.3 0.0029 17.1 0.0 3.9 3 1 0 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EGE00237.1 - 1e-09 38.6 4.6 0.3 10.8 1.9 4.6 2 2 2 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system RLI PF04068.15 EGE00237.1 - 6e-07 29.2 1.6 6e-07 29.2 1.6 2.1 2 0 0 2 2 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI Rad17 PF03215.15 EGE00237.1 - 1.7e-06 28.1 0.0 0.045 13.7 0.0 2.4 2 0 0 2 2 2 2 Rad17 P-loop domain AAA PF00004.29 EGE00237.1 - 1.8e-05 25.1 0.1 0.02 15.3 0.1 2.5 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_15 PF13175.6 EGE00237.1 - 2.8e-05 24.0 0.4 0.22 11.2 0.0 3.0 2 1 0 3 3 3 2 AAA ATPase domain AAA_22 PF13401.6 EGE00237.1 - 4.4e-05 23.8 0.0 0.0091 16.3 0.0 2.6 2 0 0 2 2 2 1 AAA domain Fer4 PF00037.27 EGE00237.1 - 8.2e-05 22.3 2.5 8.2e-05 22.3 2.5 2.2 2 0 0 2 2 2 1 4Fe-4S binding domain AAA_16 PF13191.6 EGE00237.1 - 0.00012 22.5 0.0 0.036 14.5 0.0 2.5 2 1 0 2 2 2 1 AAA ATPase domain AAA_7 PF12775.7 EGE00237.1 - 0.00035 20.2 1.1 0.0035 16.9 0.2 2.2 2 0 0 2 2 2 1 P-loop containing dynein motor region RNA_helicase PF00910.22 EGE00237.1 - 0.00044 20.6 0.0 0.25 11.8 0.0 2.8 3 0 0 3 3 2 1 RNA helicase RsgA_GTPase PF03193.16 EGE00237.1 - 0.00053 19.9 0.2 0.93 9.4 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase AAA_18 PF13238.6 EGE00237.1 - 0.0011 19.5 0.1 2 9.0 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 EGE00237.1 - 0.0012 18.6 0.4 0.94 9.3 0.0 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain Fer4_21 PF14697.6 EGE00237.1 - 0.0017 18.4 8.4 0.0034 17.5 8.4 1.5 1 0 0 1 1 1 1 4Fe-4S dicluster domain AAA_24 PF13479.6 EGE00237.1 - 0.0018 18.0 2.1 0.11 12.2 0.1 2.4 2 0 0 2 2 2 1 AAA domain SRP54 PF00448.22 EGE00237.1 - 0.0027 17.4 2.9 0.062 12.9 0.1 2.3 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain TsaE PF02367.17 EGE00237.1 - 0.0053 16.7 0.1 0.085 12.9 0.0 2.4 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE NB-ARC PF00931.22 EGE00237.1 - 0.0058 15.9 1.6 1.5 7.9 0.0 3.4 3 1 1 4 4 4 1 NB-ARC domain NACHT PF05729.12 EGE00237.1 - 0.006 16.5 2.1 0.3 11.0 0.0 2.5 2 0 0 2 2 2 1 NACHT domain Thymidylate_kin PF02223.17 EGE00237.1 - 0.0084 15.8 0.2 4.7 6.9 0.0 3.0 3 0 0 3 3 3 0 Thymidylate kinase Fer4_6 PF12837.7 EGE00237.1 - 0.0088 16.1 2.2 0.0088 16.1 2.2 2.3 2 0 0 2 2 2 1 4Fe-4S binding domain AAA_33 PF13671.6 EGE00237.1 - 0.011 15.9 0.1 2 8.6 0.1 2.6 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 EGE00237.1 - 0.015 15.1 0.4 0.64 9.7 0.0 2.4 2 0 0 2 2 2 0 AAA domain Fer4_10 PF13237.6 EGE00237.1 - 0.026 14.7 1.6 0.026 14.7 1.6 2.4 1 1 1 2 2 2 0 4Fe-4S dicluster domain AAA_5 PF07728.14 EGE00237.1 - 0.027 14.5 0.1 1.2 9.1 0.0 2.5 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_28 PF13521.6 EGE00237.1 - 0.027 14.7 0.1 4.4 7.5 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.6 EGE00237.1 - 0.028 14.9 2.8 0.59 10.6 0.2 2.4 2 0 0 2 2 2 0 AAA domain Fer4_9 PF13187.6 EGE00237.1 - 0.03 14.5 8.8 0.067 13.4 8.8 1.6 1 0 0 1 1 1 0 4Fe-4S dicluster domain TniB PF05621.11 EGE00237.1 - 0.06 12.8 0.1 0.34 10.3 0.0 2.1 2 0 0 2 2 2 0 Bacterial TniB protein AAA_13 PF13166.6 EGE00237.1 - 0.062 11.9 1.0 0.071 11.7 0.0 1.5 2 0 0 2 2 1 0 AAA domain VirE PF05272.11 EGE00237.1 - 0.067 12.9 0.0 4.4 7.0 0.0 2.4 2 0 0 2 2 2 0 Virulence-associated protein E Fer4_16 PF13484.6 EGE00237.1 - 0.075 14.0 5.5 0.084 13.8 0.2 2.7 2 0 0 2 2 2 0 4Fe-4S double cluster binding domain DnaB_C PF03796.15 EGE00237.1 - 0.11 11.9 0.0 0.28 10.5 0.0 1.6 2 0 0 2 2 2 0 DnaB-like helicase C terminal domain Fer4_17 PF13534.6 EGE00237.1 - 0.13 12.8 0.2 0.13 12.8 0.2 2.4 2 0 0 2 2 2 0 4Fe-4S dicluster domain ATPase PF06745.13 EGE00237.1 - 0.18 11.1 0.1 0.41 10.0 0.1 1.5 1 0 0 1 1 1 0 KaiC PduV-EutP PF10662.9 EGE00237.1 - 0.27 11.0 2.3 0.29 10.9 0.1 2.2 2 0 0 2 2 1 0 Ethanolamine utilisation - propanediol utilisation Fer4_7 PF12838.7 EGE00237.1 - 0.3 11.7 9.1 1.2 9.8 9.3 1.9 1 1 0 1 1 1 0 4Fe-4S dicluster domain NTPase_1 PF03266.15 EGE00237.1 - 0.42 10.5 3.2 4.6 7.1 0.1 2.8 3 0 0 3 3 2 0 NTPase Fer4_2 PF12797.7 EGE00237.1 - 1.7 8.9 6.8 0.29 11.3 1.2 2.3 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_8 PF13183.6 EGE00237.1 - 4.4 7.8 10.3 1.3 9.6 1.9 2.4 1 1 1 2 2 2 0 4Fe-4S dicluster domain FF PF01846.19 EGE00238.1 - 9.6e-59 195.4 15.2 7.3e-15 54.9 0.0 7.1 6 1 0 6 6 6 5 FF domain WW PF00397.26 EGE00238.1 - 1.6e-17 63.3 13.5 3.1e-09 36.7 1.2 2.6 2 0 0 2 2 2 2 WW domain HycH PF07450.11 EGE00238.1 - 0.092 13.1 0.6 0.36 11.2 0.6 2.1 1 0 0 1 1 1 0 Formate hydrogenlyase maturation protein HycH EMP24_GP25L PF01105.24 EGE00238.1 - 0.15 12.0 1.1 0.38 10.7 1.1 1.7 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD Glyco_hyd_101C PF17451.2 EGE00238.1 - 0.37 11.1 7.1 13 6.1 0.3 3.0 2 1 0 3 3 3 0 Glycosyl hydrolase 101 beta sandwich domain SesA PF17107.5 EGE00238.1 - 9.7 6.4 8.9 0.68 10.1 0.6 3.2 3 1 0 3 3 3 0 N-terminal domain on NACHT_NTPase and P-loop NTPases Trs65 PF12735.7 EGE00239.1 - 7.1e-85 285.2 0.0 2.2e-84 283.6 0.0 1.7 1 1 0 1 1 1 1 TRAPP trafficking subunit Trs65 Mpv17_PMP22 PF04117.12 EGE00240.1 - 7.8e-19 67.7 0.1 1.8e-18 66.5 0.1 1.6 1 0 0 1 1 1 1 Mpv17 / PMP22 family MFS_1 PF07690.16 EGE00241.1 - 2.8e-29 102.1 32.2 4.7e-28 98.1 29.8 2.0 2 0 0 2 2 2 2 Major Facilitator Superfamily p450 PF00067.22 EGE00243.1 - 7.2e-62 209.6 0.0 8.1e-62 209.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF4485 PF14846.6 EGE00243.1 - 0.41 10.7 1.4 1.4 9.0 0.0 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4485) Amidase PF01425.21 EGE00244.1 - 5.3e-83 279.5 0.0 9.2e-83 278.7 0.0 1.3 1 0 0 1 1 1 1 Amidase Arm PF00514.23 EGE00245.1 - 4.6e-95 309.1 11.0 2.1e-14 53.0 0.0 8.2 8 0 0 8 8 8 8 Armadillo/beta-catenin-like repeat IBB PF01749.20 EGE00245.1 - 1.7e-27 95.7 1.3 4.2e-27 94.4 0.6 2.0 2 0 0 2 2 2 1 Importin beta binding domain HEAT_2 PF13646.6 EGE00245.1 - 1.5e-20 73.4 0.1 3.7e-09 36.8 0.0 5.0 2 2 3 5 5 5 4 HEAT repeats Arm_3 PF16186.5 EGE00245.1 - 2.8e-20 71.6 2.9 4.3e-20 71.0 1.8 1.9 2 0 0 2 2 2 1 Atypical Arm repeat HEAT_EZ PF13513.6 EGE00245.1 - 4.4e-20 71.8 6.7 1.6e-08 34.9 0.1 6.6 5 1 2 7 7 7 4 HEAT-like repeat HEAT PF02985.22 EGE00245.1 - 1.2e-18 65.6 0.2 1.7e-05 24.7 0.0 6.8 7 0 0 7 7 7 4 HEAT repeat Arm_2 PF04826.13 EGE00245.1 - 1e-07 31.7 0.0 0.005 16.3 0.0 3.7 2 1 2 4 4 4 3 Armadillo-like V-ATPase_H_C PF11698.8 EGE00245.1 - 1.7e-05 24.9 0.0 1.1 9.4 0.0 4.6 3 2 2 5 5 5 2 V-ATPase subunit H Adaptin_N PF01602.20 EGE00245.1 - 2.9e-05 22.8 0.0 0.005 15.5 0.0 2.9 1 1 2 3 3 3 1 Adaptin N terminal region HEAT_PBS PF03130.16 EGE00245.1 - 0.00052 20.4 1.5 0.89 10.4 0.1 4.7 4 0 0 4 4 4 1 PBS lyase HEAT-like repeat CTNNBL PF08216.11 EGE00245.1 - 0.003 17.7 0.0 32 4.7 0.0 4.5 5 0 0 5 5 4 0 Catenin-beta-like, Arm-motif containing nuclear Cnd1 PF12717.7 EGE00245.1 - 0.01 15.9 0.0 7.8 6.5 0.0 3.2 2 1 1 3 3 3 0 non-SMC mitotic condensation complex subunit 1 Atx10homo_assoc PF09759.9 EGE00245.1 - 0.017 15.1 0.1 13 5.9 0.0 3.3 3 0 0 3 3 3 0 Spinocerebellar ataxia type 10 protein domain Gcn1_N PF12074.8 EGE00245.1 - 0.057 12.7 0.0 12 5.1 0.0 2.5 2 1 0 3 3 3 0 Generalcontrol nonderepressible 1 (Gcn1) N-terminal RICTOR_V PF14668.6 EGE00245.1 - 0.075 13.3 5.0 2.6 8.3 0.2 4.5 4 2 2 6 6 6 0 Rapamycin-insensitive companion of mTOR, domain 5 NopRA1 PF16201.5 EGE00245.1 - 0.12 12.0 0.0 38 3.8 0.0 3.7 2 1 1 4 4 4 0 Nucleolar pre-ribosomal-associated protein 1 NUSAP PF16006.5 EGE00245.1 - 0.37 10.5 7.8 0.52 10.0 7.8 1.2 1 0 0 1 1 1 0 Nucleolar and spindle-associated protein POT1PC PF16686.5 EGE00246.1 - 2.9e-47 160.4 1.4 2.6e-46 157.3 1.0 2.2 2 0 0 2 2 2 1 ssDNA-binding domain of telomere protection protein POT1 PF02765.17 EGE00246.1 - 1.1e-19 70.7 0.0 3.1e-19 69.2 0.0 1.8 2 0 0 2 2 2 1 Telomeric single stranded DNA binding POT1/CDC13 Gemini_AL1 PF00799.20 EGE00246.1 - 0.086 13.2 0.9 0.56 10.6 0.5 2.2 1 1 1 2 2 2 0 Geminivirus Rep catalytic domain zf-CCCH_4 PF18044.1 EGE00247.1 - 1.1 9.2 10.3 0.36 10.7 2.1 2.8 2 0 0 2 2 2 0 CCCH-type zinc finger TRAP_alpha PF03896.16 EGE00248.1 - 1e-10 41.3 0.0 1.1e-10 41.2 0.0 1.1 1 0 0 1 1 1 1 Translocon-associated protein (TRAP), alpha subunit HA2 PF04408.23 EGE00249.1 - 9.1e-16 58.1 0.4 2.3e-15 56.8 0.0 1.9 2 0 0 2 2 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 EGE00249.1 - 5.8e-15 55.4 0.0 1.1e-14 54.5 0.0 1.5 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 EGE00249.1 - 9.5e-14 51.7 0.0 2e-13 50.6 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain RWD PF05773.22 EGE00249.1 - 3.8e-11 43.3 0.1 8.3e-11 42.2 0.1 1.6 1 0 0 1 1 1 1 RWD domain DEAD PF00270.29 EGE00249.1 - 6.6e-10 39.0 0.1 1.2e-09 38.2 0.1 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase DND1_DSRM PF14709.7 EGE00249.1 - 0.0044 17.3 0.0 0.011 16.0 0.0 1.7 1 0 0 1 1 1 1 double strand RNA binding domain from DEAD END PROTEIN 1 AAA_22 PF13401.6 EGE00249.1 - 0.0052 17.1 0.8 0.031 14.5 0.8 2.3 1 1 0 1 1 1 1 AAA domain CoA_trans PF01144.23 EGE00249.1 - 0.006 16.0 0.0 0.011 15.1 0.0 1.4 1 0 0 1 1 1 1 Coenzyme A transferase T2SSE PF00437.20 EGE00249.1 - 0.012 14.6 0.0 0.023 13.7 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein UBA PF00627.31 EGE00249.1 - 0.015 15.2 0.0 0.12 12.3 0.0 2.6 3 0 0 3 3 3 0 UBA/TS-N domain AAA_29 PF13555.6 EGE00249.1 - 0.022 14.5 0.0 0.074 12.8 0.0 1.9 2 0 0 2 2 2 0 P-loop containing region of AAA domain ATPase PF06745.13 EGE00249.1 - 0.027 13.8 0.0 0.054 12.8 0.0 1.4 1 0 0 1 1 1 0 KaiC dsRBD2 PF17842.1 EGE00249.1 - 0.035 14.3 0.0 0.083 13.1 0.0 1.5 1 0 0 1 1 1 0 Double-stranded RNA binding domain 2 AAA_23 PF13476.6 EGE00249.1 - 0.074 13.5 1.0 0.16 12.4 0.0 2.0 3 0 0 3 3 1 0 AAA domain BTRD1 PF17660.1 EGE00249.1 - 0.15 11.9 0.1 0.92 9.4 0.2 2.3 2 0 0 2 2 2 0 Bacterial tandem repeat domain 1 AAA_16 PF13191.6 EGE00249.1 - 0.17 12.3 0.5 1.6 9.1 0.1 2.5 2 0 0 2 2 2 0 AAA ATPase domain NICE-3 PF07406.11 EGE00250.1 - 0.00037 20.5 0.1 0.00078 19.5 0.0 1.6 2 0 0 2 2 2 1 NICE-3 protein DUF4129 PF13559.6 EGE00250.1 - 0.011 16.0 0.0 0.037 14.3 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4129) DUF4393 PF14337.6 EGE00250.1 - 0.014 15.2 0.1 4.8 7.0 0.0 2.2 1 1 0 2 2 2 0 Domain of unknown function (DUF4393) GCFC PF07842.12 EGE00251.1 - 1.7e-86 290.3 7.6 2.9e-86 289.5 7.6 1.4 1 0 0 1 1 1 1 GC-rich sequence DNA-binding factor-like protein G-patch PF01585.23 EGE00251.1 - 5.1e-16 58.3 0.5 9.7e-16 57.4 0.5 1.5 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 EGE00251.1 - 3e-07 30.4 0.2 1e-06 28.7 0.2 1.9 1 0 0 1 1 1 1 G-patch domain ATP-synt_E PF05680.12 EGE00251.1 - 8.5 6.8 6.5 2.6 8.4 1.9 2.6 2 0 0 2 2 2 0 ATP synthase E chain Sod_Fe_C PF02777.18 EGE00252.1 - 4.4e-37 126.4 0.1 7.7e-37 125.6 0.1 1.4 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.22 EGE00252.1 - 4.8e-30 103.9 0.9 7.7e-30 103.2 0.9 1.3 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain Cnn_1N PF07989.11 EGE00253.1 - 4.5e-06 26.7 15.5 1.6e-05 24.9 15.5 1.9 1 1 0 1 1 1 1 Centrosomin N-terminal motif 1 DUF724 PF05266.14 EGE00253.1 - 0.017 14.9 7.4 0.034 14.0 7.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF724) Spc7 PF08317.11 EGE00253.1 - 0.22 10.4 16.0 0.34 9.8 16.0 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein YabA PF06156.13 EGE00253.1 - 0.55 10.9 10.5 1.7 9.3 10.5 1.9 1 0 0 1 1 1 0 Initiation control protein YabA Prominin PF05478.11 EGE00253.1 - 0.75 7.7 6.1 1.1 7.2 6.1 1.1 1 0 0 1 1 1 0 Prominin UPF0242 PF06785.11 EGE00253.1 - 0.91 9.6 19.0 1.6 8.8 19.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus AAA_23 PF13476.6 EGE00253.1 - 1.8 9.0 14.2 3.6 8.0 14.2 1.5 1 0 0 1 1 1 0 AAA domain Exonuc_VII_L PF02601.15 EGE00253.1 - 7.1 6.1 10.6 13 5.2 10.6 1.4 1 0 0 1 1 1 0 Exonuclease VII, large subunit Sld5 PF05916.11 EGE00254.1 - 2.6e-20 72.9 0.0 3.4e-20 72.5 0.0 1.2 1 0 0 1 1 1 1 GINS complex protein NOA36 PF06524.12 EGE00255.1 - 0.1 11.9 11.0 0.19 11.0 11.0 1.4 1 0 0 1 1 1 0 NOA36 protein DNA_pol_phi PF04931.13 EGE00255.1 - 0.93 7.5 11.7 1.3 7.1 11.7 1.1 1 0 0 1 1 1 0 DNA polymerase phi RNA_pol_3_Rpc31 PF11705.8 EGE00255.1 - 1.2 9.3 19.2 0.024 14.9 10.5 2.6 3 0 0 3 3 3 0 DNA-directed RNA polymerase III subunit Rpc31 CENP-B_dimeris PF09026.10 EGE00255.1 - 1.3 9.5 15.9 0.22 12.0 11.3 2.1 2 0 0 2 2 2 0 Centromere protein B dimerisation domain CDC27 PF09507.10 EGE00255.1 - 1.6 8.0 21.7 0.008 15.6 8.4 2.8 3 0 0 3 3 3 0 DNA polymerase subunit Cdc27 Sec62 PF03839.16 EGE00255.1 - 5.8 6.4 4.5 15 5.0 4.5 1.6 1 0 0 1 1 1 0 Translocation protein Sec62 ABC_tran_Xtn PF12848.7 EGE00256.1 - 0.069 13.2 0.3 0.069 13.2 0.3 2.7 2 0 0 2 2 2 0 ABC transporter CDC24 PF06395.11 EGE00258.1 - 3.5e-34 116.9 0.0 1.1e-33 115.3 0.0 1.8 2 0 0 2 2 2 1 CDC24 Calponin PH_10 PF15411.6 EGE00258.1 - 4e-34 117.5 0.0 2.7e-30 105.2 0.0 2.6 2 0 0 2 2 2 2 Pleckstrin homology domain RhoGEF PF00621.20 EGE00258.1 - 2.9e-26 92.8 0.9 5.3e-26 92.0 0.9 1.5 1 0 0 1 1 1 1 RhoGEF domain PB1 PF00564.24 EGE00258.1 - 6.6e-08 32.4 0.0 1.6e-07 31.1 0.0 1.7 1 0 0 1 1 1 1 PB1 domain WD40 PF00400.32 EGE00259.1 - 2e-27 94.9 14.1 0.00012 22.8 0.1 7.7 8 0 0 8 8 8 5 WD domain, G-beta repeat F-box-like PF12937.7 EGE00259.1 - 1.5e-11 44.0 0.3 3e-11 43.0 0.3 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EGE00259.1 - 2.1e-07 30.6 0.1 6e-07 29.2 0.1 1.8 1 0 0 1 1 1 1 F-box domain ANAPC4_WD40 PF12894.7 EGE00259.1 - 0.00038 20.7 0.2 20 5.5 0.0 4.2 2 2 2 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain BBS2_Mid PF14783.6 EGE00259.1 - 0.002 18.2 0.0 3.9 7.5 0.0 3.7 3 0 0 3 3 3 2 Ciliary BBSome complex subunit 2, middle region WD40_like PF17005.5 EGE00259.1 - 0.18 11.1 0.0 11 5.2 0.0 2.8 3 0 0 3 3 3 0 WD40-like domain SOCS PF12610.8 EGE00260.1 - 1.2 9.6 10.0 3.7 8.0 0.0 3.5 3 0 0 3 3 3 0 Suppressor of cytokine signalling Uds1 PF15456.6 EGE00261.1 - 1.5e-38 131.9 1.2 1.5e-38 131.9 1.2 6.3 4 2 2 6 6 6 1 Up-regulated During Septation TMF_DNA_bd PF12329.8 EGE00261.1 - 0.00041 20.3 10.3 0.00041 20.3 10.3 9.4 10 1 1 11 11 11 2 TATA element modulatory factor 1 DNA binding TPR_MLP1_2 PF07926.12 EGE00261.1 - 0.0022 18.0 19.3 0.0081 16.2 17.8 7.9 6 1 1 8 8 8 3 TPR/MLP1/MLP2-like protein DUF4472 PF14739.6 EGE00261.1 - 0.015 16.1 10.1 0.015 16.1 10.1 6.1 3 2 3 6 6 6 0 Domain of unknown function (DUF4472) ApoO PF09769.9 EGE00261.1 - 0.84 9.6 8.3 4.4 7.3 1.1 4.3 3 1 3 6 6 6 0 Apolipoprotein O Sin3_corepress PF08295.12 EGE00261.1 - 3.9 7.6 10.5 0.15 12.1 0.5 3.7 2 1 1 3 3 3 0 Sin3 family co-repressor DUF4407 PF14362.6 EGE00261.1 - 4.4 6.6 58.1 1.2 8.4 17.5 4.6 2 1 3 5 5 5 0 Domain of unknown function (DUF4407) Vac_Fusion PF02346.16 EGE00261.1 - 6 6.6 9.6 36 4.1 1.4 3.9 3 0 0 3 3 3 0 Chordopoxvirus multifunctional envelope protein A27 MFS_1 PF07690.16 EGE00262.1 - 7.6e-24 84.3 32.4 1.1e-23 83.8 32.4 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily UCR_hinge PF02320.16 EGE00263.1 - 1.2e-26 92.7 6.5 1.3e-26 92.6 6.5 1.0 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase hinge protein DUF5332 PF17266.2 EGE00263.1 - 0.014 15.0 1.2 0.018 14.8 1.2 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5332) UPF0203 PF05254.12 EGE00263.1 - 0.24 11.7 4.8 0.73 10.1 4.8 1.8 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0203) Vps36_ESCRT-II PF11605.8 EGE00264.1 - 0.00032 20.8 0.0 0.097 12.9 0.0 2.3 1 1 1 2 2 2 2 Vacuolar protein sorting protein 36 Vps36 DUF3439 PF11921.8 EGE00264.1 - 0.3 11.1 7.5 0.41 10.6 6.2 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) Dicty_REP PF05086.12 EGE00264.1 - 0.61 8.0 3.8 0.79 7.6 3.8 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein SSP160 PF06933.11 EGE00264.1 - 2.8 6.0 10.2 4.1 5.5 10.2 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 FAM70 PF14967.6 EGE00265.1 - 0.72 9.3 2.8 0.76 9.2 2.8 1.0 1 0 0 1 1 1 0 FAM70 protein Atg14 PF10186.9 EGE00266.1 - 4 6.4 7.0 7.9 5.5 7.0 1.5 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Acyltransferase PF01553.21 EGE00267.1 - 9.2e-10 38.3 0.0 0.00033 20.3 0.0 2.3 2 0 0 2 2 2 2 Acyltransferase Prenyltransf PF01255.19 EGE00268.1 - 1.3e-81 273.4 0.0 2.8e-81 272.3 0.0 1.5 1 1 0 1 1 1 1 Putative undecaprenyl diphosphate synthase Tmemb_cc2 PF10267.9 EGE00268.1 - 0.022 14.0 0.5 0.027 13.6 0.5 1.1 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein Zip PF02535.22 EGE00268.1 - 0.53 9.5 1.9 0.67 9.1 1.9 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter SelP_N PF04592.14 EGE00268.1 - 4.3 6.7 7.5 6.7 6.0 7.5 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Sacchrp_dh_C PF16653.5 EGE00269.1 - 1.5e-95 320.3 0.0 3.1e-95 319.3 0.0 1.5 1 1 0 1 1 1 1 Saccharopine dehydrogenase C-terminal domain Sacchrp_dh_NADP PF03435.18 EGE00269.1 - 6e-23 81.5 0.6 1e-22 80.8 0.6 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Shikimate_DH PF01488.20 EGE00269.1 - 3e-06 27.4 0.1 5.9e-06 26.4 0.1 1.6 1 1 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase NAD_binding_10 PF13460.6 EGE00269.1 - 0.0013 18.6 0.7 0.025 14.5 0.2 2.1 2 0 0 2 2 2 1 NAD(P)H-binding NAD_binding_7 PF13241.6 EGE00269.1 - 0.061 13.8 0.1 0.13 12.7 0.1 1.6 1 0 0 1 1 1 0 Putative NAD(P)-binding ADH_zinc_N_2 PF13602.6 EGE00270.1 - 1.6e-23 84.2 0.0 3.3e-23 83.2 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 EGE00270.1 - 4.5e-15 55.8 0.1 6.9e-15 55.2 0.1 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EGE00270.1 - 0.026 14.4 0.0 0.051 13.5 0.0 1.5 1 0 0 1 1 1 0 Alcohol dehydrogenase GroES-like domain PGM_PMM_II PF02879.16 EGE00270.1 - 0.14 12.8 0.0 0.52 11.0 0.0 2.0 3 0 0 3 3 3 0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II Glyco_hydro_15 PF00723.21 EGE00271.1 - 1.8e-93 313.8 0.1 2.2e-93 313.5 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 15 CBM_20 PF00686.19 EGE00271.1 - 6.3e-28 96.5 0.0 1.5e-27 95.4 0.0 1.6 1 0 0 1 1 1 1 Starch binding domain Aha1_N PF09229.11 EGE00272.1 - 1.3e-40 138.8 0.6 2.3e-40 138.0 0.6 1.4 1 0 0 1 1 1 1 Activator of Hsp90 ATPase, N-terminal AHSA1 PF08327.11 EGE00272.1 - 3.8e-19 69.1 0.1 6.5e-19 68.4 0.1 1.4 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein Mucin PF01456.17 EGE00272.1 - 2.9 7.9 16.2 5 7.1 16.2 1.3 1 0 0 1 1 1 0 Mucin-like glycoprotein FBPase PF00316.20 EGE00275.1 - 7.1e-69 231.1 0.1 9.1e-69 230.7 0.1 1.1 1 0 0 1 1 1 1 Fructose-1-6-bisphosphatase, N-terminal domain OAD_gamma PF04277.13 EGE00276.1 - 0.0067 17.0 0.6 0.02 15.5 0.6 1.9 1 1 0 1 1 1 1 Oxaloacetate decarboxylase, gamma chain SPX PF03105.19 EGE00276.1 - 0.45 10.4 3.4 0.49 10.3 3.4 1.1 1 0 0 1 1 1 0 SPX domain Orf78 PF06024.12 EGE00276.1 - 0.52 10.6 3.6 0.23 11.8 1.3 1.5 2 0 0 2 2 2 0 Orf78 (ac78) Shisa PF13908.6 EGE00276.1 - 1.5 9.0 5.1 0.62 10.3 1.6 2.0 1 1 1 2 2 2 0 Wnt and FGF inhibitory regulator Fungal_trans_2 PF11951.8 EGE00277.1 - 3.8e-40 137.9 0.2 5.1e-40 137.5 0.2 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EGE00277.1 - 2.3e-07 30.8 11.1 3.6e-07 30.2 11.1 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain E1-E2_ATPase PF00122.20 EGE00278.1 - 1.2e-37 129.2 12.0 7.8e-30 103.7 0.0 3.7 3 1 0 4 4 4 2 E1-E2 ATPase Cation_ATPase_C PF00689.21 EGE00278.1 - 5.3e-20 71.9 6.5 5.3e-20 71.9 6.5 2.5 2 1 0 2 2 2 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 EGE00278.1 - 5.5e-20 72.6 0.0 4e-19 69.7 0.0 2.3 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EGE00278.1 - 9e-17 60.9 0.0 2.1e-16 59.8 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 EGE00278.1 - 5.9e-15 54.7 0.0 1.5e-14 53.4 0.0 1.7 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 EGE00278.1 - 0.0016 18.2 0.9 0.017 14.8 1.4 2.1 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Na_Pi_cotrans PF02690.15 EGE00278.1 - 0.99 9.5 8.5 0.034 14.2 1.7 2.1 2 0 0 2 2 2 0 Na+/Pi-cotransporter HlyIII PF03006.20 EGE00279.1 - 5.1e-32 111.4 14.0 6.5e-32 111.1 14.0 1.1 1 0 0 1 1 1 1 Haemolysin-III related DUF308 PF03729.13 EGE00279.1 - 1.2 9.5 6.2 0.13 12.6 0.8 2.2 2 1 0 2 2 2 0 Short repeat of unknown function (DUF308) DUF1129 PF06570.11 EGE00279.1 - 1.5 8.3 3.8 15 5.0 3.8 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF1129) Sugar_tr PF00083.24 EGE00280.1 - 2.6e-83 280.4 23.1 3.2e-83 280.1 23.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EGE00280.1 - 2.7e-22 79.2 46.5 8.2e-16 57.9 16.8 2.2 1 1 0 2 2 2 2 Major Facilitator Superfamily DUF5090 PF17009.5 EGE00280.1 - 0.067 13.1 2.4 0.21 11.5 2.4 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF5090) V_ATPase_I PF01496.19 EGE00281.1 - 0 1074.3 0.1 0 1074.1 0.1 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family DUF1515 PF07439.11 EGE00281.1 - 0.0016 18.5 0.2 0.0048 16.9 0.2 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF1515) CheZ PF04344.13 EGE00281.1 - 0.0096 15.9 4.6 0.33 10.9 0.4 2.4 2 0 0 2 2 2 2 Chemotaxis phosphatase, CheZ DUF4988 PF16378.5 EGE00281.1 - 0.12 12.0 0.2 0.29 10.8 0.2 1.6 1 0 0 1 1 1 0 Domain of unknown function DUF1664 PF07889.12 EGE00281.1 - 0.2 11.7 3.6 10 6.1 0.1 2.9 2 2 0 2 2 2 0 Protein of unknown function (DUF1664) CdvA PF18822.1 EGE00281.1 - 0.22 11.3 5.1 11 5.8 0.0 3.4 2 1 1 3 3 3 0 CdvA-like coiled-coil domain DUF16 PF01519.16 EGE00281.1 - 0.25 11.8 2.5 8.5 6.9 0.0 3.5 3 1 0 3 3 3 0 Protein of unknown function DUF16 Tektin PF03148.14 EGE00281.1 - 0.27 9.9 7.4 0.31 9.7 2.2 2.2 2 0 0 2 2 2 0 Tektin family Filament PF00038.21 EGE00281.1 - 0.34 10.5 9.3 2.7 7.5 0.1 2.4 2 1 0 2 2 2 0 Intermediate filament protein BLOC1_2 PF10046.9 EGE00281.1 - 0.65 10.3 4.3 3.3 8.1 1.2 2.8 2 1 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF3552 PF12072.8 EGE00281.1 - 0.82 9.1 5.0 11 5.3 1.4 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3552) Fmp27_WPPW PF10359.9 EGE00281.1 - 1.7 7.4 4.7 0.69 8.7 1.3 1.8 2 0 0 2 2 2 0 RNA pol II promoter Fmp27 protein domain DivIC PF04977.15 EGE00281.1 - 2 8.2 3.9 2 8.2 0.3 2.8 3 0 0 3 3 3 0 Septum formation initiator FapA PF03961.13 EGE00281.1 - 2.7 6.5 5.6 0.51 8.9 0.6 1.8 2 0 0 2 2 2 0 Flagellar Assembly Protein A Nup54 PF13874.6 EGE00281.1 - 2.9 8.0 5.2 4.1 7.5 1.3 2.3 2 0 0 2 2 2 0 Nucleoporin complex subunit 54 HMMR_N PF15905.5 EGE00281.1 - 4 6.8 6.2 2.1 7.7 1.8 2.0 2 0 0 2 2 2 0 Hyaluronan mediated motility receptor N-terminal MOSC PF03473.17 EGE00282.1 - 6e-05 23.1 0.0 0.0001 22.3 0.0 1.5 1 1 0 1 1 1 1 MOSC domain BLM10_mid PF16507.5 EGE00283.1 - 8.2e-210 697.9 0.0 1.6e-209 697.0 0.0 1.5 1 0 0 1 1 1 1 Proteasome-substrate-size regulator, mid region DUF3437 PF11919.8 EGE00283.1 - 3.2e-27 94.3 0.0 1.4e-26 92.2 0.0 2.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3437) BLM10_N PF16547.5 EGE00283.1 - 5.6e-20 71.4 0.0 1.9e-19 69.7 0.0 1.9 1 0 0 1 1 1 1 Proteasome-substrate-size regulator, N-terminal CLASP_N PF12348.8 EGE00283.1 - 0.0057 16.3 0.1 4.8 6.7 0.0 3.4 3 0 0 3 3 3 2 CLASP N terminal HEAT PF02985.22 EGE00283.1 - 0.039 14.2 0.2 3.8 8.0 0.0 4.4 4 0 0 4 4 4 0 HEAT repeat HEAT_2 PF13646.6 EGE00283.1 - 0.04 14.3 0.1 15 6.0 0.0 3.4 3 0 0 3 3 3 0 HEAT repeats Mannosyl_trans2 PF04188.13 EGE00284.1 - 6e-39 134.6 15.7 3.2e-37 128.9 15.7 2.0 1 1 0 1 1 1 1 Mannosyltransferase (PIG-V) DBD_Tnp_Hermes PF10683.9 EGE00285.1 - 0.12 12.0 0.1 0.23 11.1 0.1 1.4 1 0 0 1 1 1 0 Hermes transposase DNA-binding domain DUF4757 PF15949.5 EGE00285.1 - 1.6 9.2 4.8 3.7 8.0 3.6 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4757) Peptidase_S8 PF00082.22 EGE00286.1 - 5.4e-31 108.0 1.4 6.5e-31 107.7 1.4 1.0 1 0 0 1 1 1 1 Subtilase family PepSY_TM PF03929.16 EGE00287.1 - 0.28 10.8 0.2 0.36 10.5 0.2 1.2 1 1 0 1 1 1 0 PepSY-associated TM region BUD22 PF09073.10 EGE00287.1 - 2.8 7.2 8.0 3.1 7.1 8.0 1.0 1 0 0 1 1 1 0 BUD22 Metallophos PF00149.28 EGE00288.1 - 3.5e-11 44.0 0.2 7.1e-11 43.0 0.2 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EGE00288.1 - 0.00043 20.5 0.0 0.0045 17.2 0.0 2.2 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain PX PF00787.24 EGE00289.1 - 8.8e-19 67.6 0.4 2.2e-18 66.3 0.4 1.6 1 0 0 1 1 1 1 PX domain Vps5 PF09325.10 EGE00289.1 - 2e-12 47.2 7.3 3.5e-06 26.7 0.1 2.1 1 1 0 2 2 2 2 Vps5 C terminal like DUF1664 PF07889.12 EGE00289.1 - 0.031 14.3 0.4 2.1 8.4 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Occludin_ELL PF07303.13 EGE00289.1 - 0.14 12.9 2.9 2 9.2 0.0 2.8 3 0 0 3 3 3 0 Occludin homology domain FAD_binding_3 PF01494.19 EGE00291.1 - 1.1e-21 77.5 0.0 1.2e-19 70.8 0.0 2.3 1 1 0 1 1 1 1 FAD binding domain Lycopene_cycl PF05834.12 EGE00291.1 - 0.00014 21.1 0.0 0.0045 16.1 0.0 2.3 2 0 0 2 2 2 1 Lycopene cyclase protein Pyr_redox_2 PF07992.14 EGE00291.1 - 0.0039 16.5 0.0 0.0055 16.0 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EGE00291.1 - 0.0086 16.1 0.0 0.015 15.3 0.0 1.3 1 0 0 1 1 1 1 FAD-NAD(P)-binding SE PF08491.10 EGE00291.1 - 0.011 14.8 0.0 0.017 14.2 0.0 1.2 1 0 0 1 1 1 0 Squalene epoxidase DAO PF01266.24 EGE00291.1 - 0.015 14.9 0.0 0.26 10.8 0.0 2.1 2 0 0 2 2 2 0 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EGE00291.1 - 0.037 14.2 0.0 0.11 12.7 0.0 1.8 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.6 EGE00291.1 - 0.1 11.8 0.0 0.15 11.2 0.0 1.2 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) tRNA-synt_His PF13393.6 EGE00292.1 - 2e-36 125.9 0.0 3.2e-30 105.5 0.0 2.1 2 0 0 2 2 2 2 Histidyl-tRNA synthetase HGTP_anticodon PF03129.20 EGE00292.1 - 1.7e-13 50.5 0.0 3.2e-13 49.6 0.0 1.5 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_2b PF00587.25 EGE00292.1 - 2.4e-05 24.4 0.0 4.8e-05 23.4 0.0 1.4 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon2 PF12745.7 EGE00292.1 - 0.0055 16.3 0.0 0.0096 15.5 0.0 1.4 1 0 0 1 1 1 1 Anticodon binding domain of tRNAs Ribosomal_60s PF00428.19 EGE00292.1 - 0.34 11.5 2.6 1.5 9.4 0.1 2.6 2 0 0 2 2 2 0 60s Acidic ribosomal protein dUTPase PF00692.19 EGE00293.1 - 2e-08 34.0 0.0 2.7e-08 33.5 0.0 1.2 1 0 0 1 1 1 1 dUTPase DUF3246 PF11596.8 EGE00293.1 - 0.022 14.2 0.3 0.027 13.9 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3246) SURF6 PF04935.12 EGE00294.1 - 0.00087 19.1 6.8 0.001 18.9 6.8 1.2 1 0 0 1 1 1 1 Surfeit locus protein 6 DUF2956 PF11169.8 EGE00294.1 - 0.058 13.6 1.3 0.15 12.2 1.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2956) AUX_IAA PF02309.16 EGE00294.1 - 0.29 10.9 3.0 0.36 10.7 3.0 1.1 1 0 0 1 1 1 0 AUX/IAA family CDC45 PF02724.14 EGE00294.1 - 1.9 6.7 4.2 1.8 6.7 4.2 1.1 1 0 0 1 1 1 0 CDC45-like protein UCH PF00443.29 EGE00295.1 - 5.3e-55 186.7 0.6 5.3e-55 186.7 0.6 2.1 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EGE00295.1 - 3.9e-27 95.7 1.4 2.1e-26 93.3 1.4 2.2 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Nop53 PF07767.11 EGE00295.1 - 1.6 8.0 24.8 0.92 8.8 21.5 2.2 2 0 0 2 2 2 0 Nop53 (60S ribosomal biogenesis) CAF-1_p150 PF11600.8 EGE00295.1 - 1.8 8.2 29.9 6.3 6.5 29.9 1.9 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal DUF4407 PF14362.6 EGE00295.1 - 8 5.7 8.0 18 4.6 8.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Yos1 PF08571.10 EGE00296.1 - 8.8e-33 112.4 0.2 1e-32 112.2 0.2 1.0 1 0 0 1 1 1 1 Yos1-like Glyco_transf_22 PF03901.17 EGE00297.1 - 1.9e-37 129.5 14.2 2.5e-37 129.1 14.2 1.1 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family DUF1772 PF08592.11 EGE00297.1 - 4.5 7.6 16.4 0.051 13.9 3.5 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF1772) Dynamitin PF04912.14 EGE00298.1 - 8.5e-73 245.9 11.3 4e-71 240.4 11.3 2.2 1 1 0 1 1 1 1 Dynamitin APG6_N PF17675.1 EGE00298.1 - 0.0013 19.2 11.8 0.69 10.4 2.1 3.3 3 0 0 3 3 3 2 Apg6 coiled-coil region Jnk-SapK_ap_N PF09744.9 EGE00298.1 - 0.003 17.8 11.4 0.012 15.9 0.7 3.0 3 0 0 3 3 3 1 JNK_SAPK-associated protein-1 TPR_MLP1_2 PF07926.12 EGE00298.1 - 0.0038 17.3 2.8 0.0038 17.3 2.8 3.7 5 0 0 5 5 3 1 TPR/MLP1/MLP2-like protein SOGA PF11365.8 EGE00298.1 - 0.0048 18.0 6.2 0.13 13.4 0.6 3.2 3 0 0 3 3 3 1 Protein SOGA DivIC PF04977.15 EGE00298.1 - 0.0051 16.5 13.3 0.034 13.9 1.2 3.5 3 0 0 3 3 3 1 Septum formation initiator MnmE_helical PF12631.7 EGE00298.1 - 0.0086 16.3 3.1 0.08 13.1 0.2 2.2 2 0 0 2 2 2 1 MnmE helical domain DUF4407 PF14362.6 EGE00298.1 - 0.013 14.8 14.1 0.51 9.7 7.8 2.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) DUF2408 PF10303.9 EGE00298.1 - 0.014 16.0 3.9 0.79 10.3 0.4 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF2408) SKA2 PF16740.5 EGE00298.1 - 0.022 14.5 3.3 0.36 10.6 0.0 3.2 3 0 0 3 3 3 0 Spindle and kinetochore-associated protein 2 DHR10 PF18595.1 EGE00298.1 - 0.023 14.8 1.6 0.023 14.8 1.6 3.3 3 0 0 3 3 3 0 Designed helical repeat protein 10 domain pPIWI_RE_REase PF18154.1 EGE00298.1 - 0.035 14.1 0.1 0.078 12.9 0.1 1.5 1 0 0 1 1 1 0 REase associating with pPIWI_RE DUF2203 PF09969.9 EGE00298.1 - 0.04 14.6 7.3 0.48 11.2 0.7 3.7 3 1 1 4 4 3 0 Uncharacterized conserved protein (DUF2203) DUF4618 PF15397.6 EGE00298.1 - 0.056 12.9 2.4 0.95 8.8 0.2 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4618) DUF4200 PF13863.6 EGE00298.1 - 0.094 13.1 11.1 0.59 10.5 3.1 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4200) Laminin_II PF06009.12 EGE00298.1 - 0.1 12.6 0.4 0.1 12.6 0.4 3.0 4 1 1 5 5 3 0 Laminin Domain II DUF812 PF05667.11 EGE00298.1 - 0.12 11.3 4.7 0.025 13.5 0.7 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF812) ADIP PF11559.8 EGE00298.1 - 0.15 12.2 9.0 0.89 9.6 0.5 3.4 3 0 0 3 3 3 0 Afadin- and alpha -actinin-Binding SlyX PF04102.12 EGE00298.1 - 0.17 12.5 16.0 0.2 12.3 1.7 4.4 4 1 0 4 4 4 0 SlyX HZS_alpha PF18582.1 EGE00298.1 - 0.19 12.2 0.1 0.83 10.2 0.0 2.0 2 0 0 2 2 1 0 Hydrazine synthase alpha subunit middle domain FH2 PF02181.23 EGE00298.1 - 0.26 10.3 3.7 0.16 11.0 0.2 2.3 3 0 0 3 3 3 0 Formin Homology 2 Domain DUF16 PF01519.16 EGE00298.1 - 0.27 11.7 4.5 0.19 12.2 0.7 2.6 3 0 0 3 3 2 0 Protein of unknown function DUF16 Ax_dynein_light PF10211.9 EGE00298.1 - 0.31 11.0 7.7 4.1 7.3 0.4 2.7 3 0 0 3 3 2 0 Axonemal dynein light chain OmpH PF03938.14 EGE00298.1 - 0.36 11.1 11.3 0.36 11.2 2.5 3.2 3 0 0 3 3 3 0 Outer membrane protein (OmpH-like) Muted PF14942.6 EGE00298.1 - 0.42 11.0 9.0 2 8.8 0.8 3.2 2 1 1 3 3 3 0 Organelle biogenesis, Muted-like protein LPP PF04728.13 EGE00298.1 - 0.44 11.0 13.8 0.54 10.7 0.6 4.3 4 0 0 4 4 4 0 Lipoprotein leucine-zipper Prefoldin_2 PF01920.20 EGE00298.1 - 0.49 10.4 12.6 2.3 8.2 3.4 3.5 3 1 0 3 3 3 0 Prefoldin subunit KxDL PF10241.9 EGE00298.1 - 0.56 10.5 3.4 0.54 10.6 0.4 2.5 3 0 0 3 3 2 0 Uncharacterized conserved protein Spc7 PF08317.11 EGE00298.1 - 0.65 8.8 10.7 0.14 11.0 2.1 2.8 3 0 0 3 3 3 0 Spc7 kinetochore protein Cob_adeno_trans PF01923.18 EGE00298.1 - 0.66 10.1 4.2 36 4.5 0.5 3.1 3 0 0 3 3 3 0 Cobalamin adenosyltransferase DUF1664 PF07889.12 EGE00298.1 - 0.69 10.0 3.4 0.72 9.9 0.1 2.7 3 1 0 3 3 3 0 Protein of unknown function (DUF1664) Spectrin PF00435.21 EGE00298.1 - 0.7 10.4 8.1 21 5.7 1.7 3.4 3 0 0 3 3 3 0 Spectrin repeat Golgin_A5 PF09787.9 EGE00298.1 - 0.71 9.3 6.8 0.45 9.9 1.0 2.3 2 0 0 2 2 2 0 Golgin subfamily A member 5 Atg14 PF10186.9 EGE00298.1 - 0.92 8.5 6.9 2.8 6.9 0.4 2.6 3 0 0 3 3 3 0 Vacuolar sorting 38 and autophagy-related subunit 14 Csm1_N PF18504.1 EGE00298.1 - 1.1 9.6 13.2 6.2 7.2 1.7 3.4 3 0 0 3 3 3 0 Csm1 N-terminal domain Cnn_1N PF07989.11 EGE00298.1 - 1.3 9.2 8.3 4.8 7.4 0.7 2.8 2 0 0 2 2 2 0 Centrosomin N-terminal motif 1 DUF4140 PF13600.6 EGE00298.1 - 1.6 9.2 15.8 7.7 7.0 0.7 4.1 3 2 0 3 3 3 0 N-terminal domain of unknown function (DUF4140) FliD_C PF07195.12 EGE00298.1 - 1.8 7.9 4.9 0.8 9.1 2.1 1.8 2 1 0 2 2 2 0 Flagellar hook-associated protein 2 C-terminus Spc24 PF08286.11 EGE00298.1 - 1.9 8.8 12.7 4.8 7.5 0.6 3.6 4 0 0 4 4 3 0 Spc24 subunit of Ndc80 DUF4337 PF14235.6 EGE00298.1 - 1.9 8.6 10.0 3.4 7.8 0.4 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4337) Fmp27_WPPW PF10359.9 EGE00298.1 - 2.2 7.0 6.3 2.2 7.0 0.4 2.7 3 0 0 3 3 3 0 RNA pol II promoter Fmp27 protein domain COG2 PF06148.11 EGE00298.1 - 2.4 8.3 4.4 2.7 8.1 0.3 2.7 3 0 0 3 3 2 0 COG (conserved oligomeric Golgi) complex component, COG2 ZapB PF06005.12 EGE00298.1 - 2.5 8.6 12.5 25 5.4 3.3 3.6 3 0 0 3 3 3 0 Cell division protein ZapB GrpE PF01025.19 EGE00298.1 - 2.7 7.6 7.6 16 5.1 0.7 3.1 3 0 0 3 3 3 0 GrpE JIP_LZII PF16471.5 EGE00298.1 - 2.8 8.2 13.8 0.56 10.4 3.6 3.4 3 0 0 3 3 3 0 JNK-interacting protein leucine zipper II Snapin_Pallidin PF14712.6 EGE00298.1 - 3.1 8.3 8.8 5.4 7.5 1.5 4.2 4 1 0 4 4 4 0 Snapin/Pallidin BLOC1_2 PF10046.9 EGE00298.1 - 3.4 8.0 6.2 2.7 8.3 0.4 3.3 4 1 0 4 4 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DASH_Hsk3 PF08227.11 EGE00298.1 - 9 6.8 6.9 14 6.2 2.0 3.2 3 0 0 3 3 2 0 DASH complex subunit Hsk3 like MbeD_MobD PF04899.12 EGE00298.1 - 9.2 6.5 7.3 0.88 9.7 0.7 2.7 4 0 0 4 4 2 0 MbeD/MobD like Peptidase_M24 PF00557.24 EGE00300.1 - 4.8e-38 130.9 0.3 7.1e-38 130.4 0.3 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 DUF3570 PF12094.8 EGE00300.1 - 0.16 10.8 0.1 0.25 10.1 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3570) CDC45 PF02724.14 EGE00300.1 - 0.61 8.3 2.0 0.83 7.9 2.0 1.1 1 0 0 1 1 1 0 CDC45-like protein Aldedh PF00171.22 EGE00301.1 - 4e-136 454.2 0.7 5.4e-136 453.8 0.7 1.2 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Wtap PF17098.5 EGE00301.1 - 0.035 14.0 0.6 0.071 13.0 0.6 1.5 1 0 0 1 1 1 0 WTAP/Mum2p family Calreticulin PF00262.18 EGE00302.1 - 1.3e-171 570.5 15.5 1.3e-171 570.5 15.5 1.7 2 0 0 2 2 2 1 Calreticulin family OAD_gamma PF04277.13 EGE00302.1 - 1.4 9.5 5.3 2.2 8.9 0.1 3.5 3 0 0 3 3 3 0 Oxaloacetate decarboxylase, gamma chain Aldolase_II PF00596.21 EGE00303.1 - 6.7e-44 150.1 0.0 7.9e-44 149.8 0.0 1.1 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain Vps5 PF09325.10 EGE00304.1 - 3.1e-89 298.6 4.0 3.1e-89 298.6 4.0 1.4 2 0 0 2 2 2 1 Vps5 C terminal like PX PF00787.24 EGE00304.1 - 2.3e-25 88.8 0.2 5.6e-25 87.5 0.0 1.8 2 0 0 2 2 2 1 PX domain BAR_3 PF16746.5 EGE00304.1 - 0.043 13.5 6.5 0.19 11.4 2.7 2.5 1 1 1 2 2 2 0 BAR domain of APPL family NifQ PF04891.12 EGE00304.1 - 0.41 11.0 1.9 0.9 9.9 1.9 1.5 1 0 0 1 1 1 0 NifQ PilJ PF13675.6 EGE00304.1 - 0.85 9.7 5.5 0.33 11.0 0.4 2.8 3 0 0 3 3 3 0 Type IV pili methyl-accepting chemotaxis transducer N-term Ribosomal_60s PF00428.19 EGE00305.1 - 0.25 11.9 6.8 0.48 11.0 6.8 1.4 1 0 0 1 1 1 0 60s Acidic ribosomal protein Flavin_Reduct PF01613.18 EGE00306.1 - 3.2e-23 82.5 1.9 8.5e-23 81.1 1.9 1.7 1 1 0 1 1 1 1 Flavin reductase like domain Macoilin PF09726.9 EGE00307.1 - 4.8 5.6 8.1 17 3.8 8.1 1.8 1 1 0 1 1 1 0 Macoilin family Kunitz_legume PF00197.18 EGE00308.1 - 0.027 14.4 0.0 0.038 13.9 0.0 1.2 1 0 0 1 1 1 0 Trypsin and protease inhibitor 4HBT_2 PF13279.6 EGE00309.1 - 1.1e-19 71.1 0.0 1.8e-19 70.4 0.0 1.2 1 0 0 1 1 1 1 Thioesterase-like superfamily PspB PF06667.12 EGE00309.1 - 0.047 13.8 0.1 0.086 12.9 0.1 1.4 1 0 0 1 1 1 0 Phage shock protein B Complex1_LYR_2 PF13233.6 EGE00310.1 - 0.00034 21.3 0.4 0.00044 21.0 0.4 1.2 1 0 0 1 1 1 1 Complex1_LYR-like Complex1_LYR PF05347.15 EGE00310.1 - 0.0034 17.4 0.3 0.0048 16.9 0.3 1.4 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Methyltransf_25 PF13649.6 EGE00311.1 - 1.1e-12 48.5 0.0 1.9e-12 47.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EGE00311.1 - 8.3e-11 42.4 0.0 1.8e-10 41.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EGE00311.1 - 2.2e-08 34.0 0.0 3.3e-08 33.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EGE00311.1 - 6.2e-06 25.7 0.0 1e-05 25.0 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.6 EGE00311.1 - 3.1e-05 23.9 0.0 6.1e-05 22.9 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EGE00311.1 - 4.4e-05 24.1 0.0 7.9e-05 23.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Exo_endo_phos PF03372.23 EGE00312.1 - 2.4e-22 79.6 0.0 1.7e-21 76.8 0.0 2.2 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family LRR_8 PF13855.6 EGE00312.1 - 1.6e-14 53.4 27.5 1.3e-07 31.3 7.6 2.3 1 1 2 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 EGE00312.1 - 1.3e-10 41.4 9.8 3.5e-06 27.3 1.6 2.5 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EGE00312.1 - 0.047 13.2 0.2 0.087 12.3 0.2 1.3 1 0 0 1 1 1 0 Leucine-rich repeat LRR_1 PF00560.33 EGE00312.1 - 0.31 11.8 5.0 5.5 7.9 0.0 4.3 4 0 0 4 4 4 0 Leucine Rich Repeat MFS_1 PF07690.16 EGE00314.1 - 1.6e-44 152.3 47.9 4.1e-44 150.9 47.4 1.8 2 0 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EGE00314.1 - 2.2e-23 82.5 17.6 6.3e-20 71.1 15.9 2.1 2 0 0 2 2 2 2 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 EGE00314.1 - 2e-19 69.8 0.9 2e-19 69.8 0.9 2.6 2 0 0 2 2 2 1 Sugar (and other) transporter MFS_4 PF06779.14 EGE00314.1 - 3.6e-06 26.5 11.5 6.5e-05 22.4 4.9 2.8 2 1 0 2 2 2 2 Uncharacterised MFS-type transporter YbfB EptA_B_N PF08019.12 EGE00314.1 - 0.0033 17.3 0.1 0.0033 17.3 0.1 2.9 4 0 0 4 4 4 1 Phosphoethanolamine transferase EptA/EptB Peptidase_M56 PF05569.11 EGE00314.1 - 0.031 13.5 0.2 0.051 12.8 0.2 1.3 1 0 0 1 1 1 0 BlaR1 peptidase M56 OATP PF03137.20 EGE00314.1 - 2.3 6.4 12.5 0.071 11.4 3.7 2.7 2 2 1 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family HET PF06985.11 EGE00315.1 - 7.8e-22 78.2 0.0 1.3e-21 77.4 0.0 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Anti-TRAP PF15777.5 EGE00315.1 - 0.064 13.2 0.7 0.26 11.3 0.1 2.2 2 0 0 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein GCD14 PF08704.10 EGE00316.1 - 3.3e-07 30.3 0.0 0.00067 19.4 0.0 2.4 2 0 0 2 2 2 2 tRNA methyltransferase complex GCD14 subunit GCD14_N PF14801.6 EGE00316.1 - 6.5e-06 25.9 2.0 1.1e-05 25.2 0.9 1.9 2 0 0 2 2 2 1 tRNA methyltransferase complex GCD14 subunit N-term Methyltransf_31 PF13847.6 EGE00316.1 - 0.011 15.5 0.0 5.3 6.8 0.0 2.3 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_11 PF08241.12 EGE00316.1 - 0.074 13.7 0.0 17 6.1 0.0 2.9 3 0 0 3 3 3 0 Methyltransferase domain Methyltransf_25 PF13649.6 EGE00316.1 - 0.081 13.6 0.0 3.5 8.4 0.0 2.8 2 1 0 2 2 2 0 Methyltransferase domain Metallophos PF00149.28 EGE00317.1 - 7.3e-19 69.1 0.5 7.3e-19 69.1 0.5 1.8 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EGE00317.1 - 1.6e-06 28.4 0.0 0.002 18.3 0.0 2.2 2 0 0 2 2 2 2 Calcineurin-like phosphoesterase superfamily domain NAD_binding_6 PF08030.12 EGE00318.1 - 4e-05 23.8 0.5 0.0007 19.7 0.2 2.5 2 1 0 2 2 2 1 Ferric reductase NAD binding domain NAD_binding_1 PF00175.21 EGE00318.1 - 5.6e-05 23.7 0.0 0.013 16.2 0.0 2.8 1 1 0 1 1 1 1 Oxidoreductase NAD-binding domain SopE_GEF PF07487.13 EGE00318.1 - 0.21 11.7 0.0 0.4 10.8 0.0 1.3 1 0 0 1 1 1 0 SopE GEF domain MARVEL PF01284.23 EGE00319.1 - 0.0013 18.8 2.4 0.0019 18.2 2.4 1.4 1 0 0 1 1 1 1 Membrane-associating domain SHR3_chaperone PF08229.11 EGE00319.1 - 0.1 11.5 0.0 0.15 11.0 0.0 1.2 1 0 0 1 1 1 0 ER membrane protein SH3 CD20 PF04103.15 EGE00319.1 - 0.17 12.0 2.5 0.38 10.8 2.5 1.5 1 1 0 1 1 1 0 CD20-like family COesterase PF00135.28 EGE00320.1 - 3.1e-55 188.0 0.0 5.2e-55 187.3 0.0 1.3 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EGE00320.1 - 1.4e-06 28.3 0.1 4.3e-06 26.7 0.1 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold HMA PF00403.26 EGE00321.1 - 2.5e-51 172.0 0.2 3.9e-12 46.4 0.0 4.5 4 0 0 4 4 4 4 Heavy-metal-associated domain E1-E2_ATPase PF00122.20 EGE00321.1 - 2e-47 161.1 1.4 7.2e-47 159.2 1.4 2.0 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.26 EGE00321.1 - 1.9e-36 126.3 1.1 5e-36 125.0 0.1 2.2 3 0 0 3 3 3 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 EGE00321.1 - 3.2e-05 23.8 0.0 0.0035 17.1 0.0 2.4 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase B12-binding PF02310.19 EGE00321.1 - 0.0045 17.0 0.0 2.7 8.1 0.0 4.3 5 0 0 5 5 5 1 B12 binding domain DUF1930 PF09122.10 EGE00321.1 - 0.078 13.0 1.2 27 4.8 0.1 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF1930) CSN7a_helixI PF18392.1 EGE00322.1 - 0.0015 18.4 0.0 0.0031 17.4 0.0 1.4 1 0 0 1 1 1 1 COP9 signalosome complex subunit 7a helix I domain PCI PF01399.27 EGE00322.1 - 0.0043 17.6 0.0 0.0068 16.9 0.0 1.3 1 0 0 1 1 1 1 PCI domain RGS PF00615.19 EGE00323.1 - 5.4e-13 49.2 0.0 4.4e-09 36.6 0.0 2.2 2 0 0 2 2 2 2 Regulator of G protein signaling domain Bromodomain PF00439.25 EGE00324.1 - 1.1e-24 86.3 1.0 2.3e-24 85.3 1.0 1.5 1 0 0 1 1 1 1 Bromodomain Acetyltransf_1 PF00583.25 EGE00324.1 - 3.2e-08 33.8 0.0 6.1e-08 32.9 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EGE00324.1 - 1.1e-06 28.7 0.1 1.9e-06 27.8 0.1 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EGE00324.1 - 0.00036 20.9 0.1 0.00064 20.1 0.1 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Ost5 PF05251.12 EGE00325.1 - 2.5e-19 69.3 9.0 2.9e-19 69.1 9.0 1.0 1 0 0 1 1 1 1 Oligosaccharyltransferase subunit 5 Rad1 PF02144.16 EGE00326.1 - 3.4e-88 295.3 0.1 4e-88 295.1 0.1 1.0 1 0 0 1 1 1 1 Repair protein Rad1/Rec1/Rad17 AAA_23 PF13476.6 EGE00327.1 - 1.1e-32 114.2 2.1 1.1e-32 114.2 2.1 7.7 1 1 2 3 3 3 1 AAA domain AAA_15 PF13175.6 EGE00327.1 - 4.7e-13 49.6 8.1 8.5e-09 35.6 0.0 5.2 1 1 3 5 5 5 2 AAA ATPase domain SbcCD_C PF13558.6 EGE00327.1 - 1e-06 28.9 0.0 2.8e-06 27.5 0.0 1.8 1 0 0 1 1 1 1 Putative exonuclease SbcCD, C subunit SMC_N PF02463.19 EGE00327.1 - 3.2e-06 26.7 0.0 3.2e-06 26.7 0.0 3.4 2 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EGE00327.1 - 0.00018 21.4 21.9 0.0022 17.8 0.0 3.9 3 1 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EGE00327.1 - 0.00076 19.2 0.0 0.0017 18.1 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.6 EGE00327.1 - 0.017 15.5 0.0 0.017 15.5 0.0 5.1 6 3 0 6 6 6 0 AAA ATPase domain AAA_22 PF13401.6 EGE00327.1 - 0.12 12.7 0.1 0.12 12.7 0.1 4.6 5 2 1 6 6 6 0 AAA domain CBP_BcsR PF10945.8 EGE00327.1 - 0.13 11.7 2.8 2.2 7.9 0.1 3.2 2 0 0 2 2 2 0 Cellulose biosynthesis protein BcsR TBD PF12845.7 EGE00327.1 - 3.7 7.5 7.5 54 3.8 0.0 4.7 4 0 0 4 4 4 0 TBD domain PPP4R2 PF09184.11 EGE00328.1 - 8.4e-11 42.0 0.0 1.4e-10 41.2 0.0 1.4 1 0 0 1 1 1 1 PPP4R2 DUF3480 PF11979.8 EGE00329.1 - 0.025 13.6 0.1 0.99 8.3 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3480) zf-C2H2 PF00096.26 EGE00330.1 - 1.7e-12 47.1 13.9 3.9e-06 27.0 2.4 3.8 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EGE00330.1 - 7.2e-11 42.0 10.1 1.4e-06 28.4 0.2 3.6 3 0 0 3 3 3 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 EGE00330.1 - 1.4e-08 34.8 11.4 0.00092 19.9 1.6 3.9 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_6 PF13912.6 EGE00330.1 - 8.6e-07 28.8 5.2 0.0022 17.9 0.5 3.4 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EGE00330.1 - 5.1e-06 26.6 0.2 0.067 13.5 0.2 3.4 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EGE00330.1 - 0.00018 21.8 1.4 0.013 15.9 0.3 3.1 3 0 0 3 3 3 1 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.5 EGE00330.1 - 0.00031 20.4 5.6 0.094 12.5 0.6 3.4 3 0 0 3 3 3 1 zinc-finger C2H2-type Zn_ribbon_recom PF13408.6 EGE00330.1 - 0.019 15.4 1.3 0.048 14.2 1.3 1.6 1 0 0 1 1 1 0 Recombinase zinc beta ribbon domain zf-Di19 PF05605.12 EGE00330.1 - 0.093 13.0 1.6 0.19 12.1 1.6 1.5 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-C2HE PF16278.5 EGE00330.1 - 0.16 12.4 2.1 4.1 7.9 0.4 2.6 1 1 1 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger LIM PF00412.22 EGE00330.1 - 0.74 10.1 2.3 14 6.0 0.2 2.4 1 1 1 2 2 2 0 LIM domain C5HCH PF17982.1 EGE00330.1 - 2.4 8.4 6.3 18 5.6 1.2 2.5 1 1 1 2 2 2 0 NSD Cys-His rich domain Pkinase PF00069.25 EGE00332.1 - 4.7e-34 118.0 1.0 1.2e-15 57.6 0.4 3.3 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EGE00332.1 - 4.3e-16 59.0 0.5 4e-15 55.8 0.3 2.4 2 1 0 2 2 2 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EGE00332.1 - 0.0005 19.0 0.0 0.0016 17.3 0.0 1.8 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EGE00332.1 - 0.026 14.4 0.1 0.19 11.6 0.0 2.2 2 0 0 2 2 2 0 Phosphotransferase enzyme family zf-C2H2 PF00096.26 EGE00334.1 - 1.3e-08 34.9 14.9 0.00091 19.6 2.4 3.6 3 1 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EGE00334.1 - 1.5e-06 28.4 6.7 0.28 11.7 0.2 3.7 3 0 0 3 3 3 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 EGE00334.1 - 0.00011 22.7 12.0 0.0095 16.7 1.9 3.8 3 1 0 3 3 3 2 C2H2-type zinc finger zf-H2C2_5 PF13909.6 EGE00334.1 - 0.05 13.4 0.7 0.05 13.4 0.7 4.0 4 0 0 4 4 4 0 C2H2-type zinc-finger domain zf-Di19 PF05605.12 EGE00334.1 - 0.055 13.8 5.0 0.091 13.1 0.6 2.3 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding Mfp-3 PF04202.13 EGE00334.1 - 0.12 12.8 0.0 0.12 12.8 0.0 1.6 2 0 0 2 2 2 0 Foot protein 3 SelP_N PF04592.14 EGE00335.1 - 0.37 10.1 19.2 0.63 9.4 19.2 1.3 1 0 0 1 1 1 0 Selenoprotein P, N terminal region SelK_SelG PF10961.8 EGE00335.1 - 1.6 9.4 8.8 1.6 9.4 1.8 2.4 2 0 0 2 2 2 0 Selenoprotein SelK_SelG APH PF01636.23 EGE00336.1 - 4.8e-43 147.8 0.0 7.9e-43 147.1 0.0 1.4 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 EGE00336.1 - 1.3e-05 24.7 0.0 0.00011 21.6 0.0 2.1 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family EcKinase PF02958.20 EGE00336.1 - 0.0014 18.0 0.1 0.0033 16.8 0.0 1.6 2 0 0 2 2 2 1 Ecdysteroid kinase Fructosamin_kin PF03881.14 EGE00336.1 - 0.0047 16.2 0.0 0.07 12.3 0.0 2.2 1 1 0 1 1 1 1 Fructosamine kinase RIO1 PF01163.22 EGE00336.1 - 0.033 13.8 0.0 0.61 9.7 0.0 2.2 2 0 0 2 2 2 0 RIO1 family DUF4142 PF13628.6 EGE00336.1 - 0.14 12.4 0.3 0.25 11.6 0.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4142) Cytochrom_B561 PF03188.16 EGE00337.1 - 0.013 15.6 10.4 0.013 15.6 10.4 1.7 2 0 0 2 2 2 0 Eukaryotic cytochrome b561 DUF4079 PF13301.6 EGE00337.1 - 3 8.0 19.3 0.7 10.0 2.7 4.2 3 1 2 5 5 5 0 Protein of unknown function (DUF4079) DUF2427 PF10348.9 EGE00337.1 - 9.5 6.1 9.9 0.85 9.4 4.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF2427) ATP-synt_DE_N PF02823.16 EGE00338.1 - 2.5e-15 56.1 0.0 3.9e-15 55.5 0.0 1.2 1 0 0 1 1 1 1 ATP synthase, Delta/Epsilon chain, beta-sandwich domain Ribosomal_L29e PF01779.17 EGE00339.1 - 6e-22 77.7 12.6 9e-22 77.1 12.6 1.3 1 0 0 1 1 1 1 Ribosomal L29e protein family NCBP3 PF10309.9 EGE00340.1 - 1e-23 82.9 0.0 2.1e-23 81.9 0.0 1.5 1 0 0 1 1 1 1 Nuclear cap-binding protein subunit 3 Cu-oxidase_3 PF07732.15 EGE00341.1 - 9.1e-12 45.0 0.5 4.9e-08 33.0 0.2 2.6 2 1 1 3 3 3 2 Multicopper oxidase Cu-oxidase_2 PF07731.14 EGE00341.1 - 5e-10 39.3 0.1 0.0032 17.2 0.0 3.2 2 1 0 2 2 2 2 Multicopper oxidase Cu-oxidase PF00394.22 EGE00341.1 - 0.0055 16.8 0.0 0.0088 16.2 0.0 1.3 1 0 0 1 1 1 1 Multicopper oxidase Copper-bind PF00127.20 EGE00341.1 - 0.18 12.3 0.0 0.51 10.8 0.0 1.8 1 0 0 1 1 1 0 Copper binding proteins, plastocyanin/azurin family ABC_tran PF00005.27 EGE00342.1 - 8e-48 162.4 0.0 3.3e-29 102.2 0.0 3.0 3 0 0 3 3 2 2 ABC transporter ABC_membrane PF00664.23 EGE00342.1 - 5.9e-31 108.1 20.4 5.1e-21 75.5 6.0 2.7 2 0 0 2 2 2 2 ABC transporter transmembrane region SMC_N PF02463.19 EGE00342.1 - 2.5e-09 36.9 4.6 0.00065 19.2 1.0 4.8 4 1 0 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EGE00342.1 - 2e-06 27.4 0.7 0.044 13.5 0.1 3.3 3 0 0 3 3 3 2 P-loop containing region of AAA domain AAA_23 PF13476.6 EGE00342.1 - 9.1e-05 23.0 0.7 0.21 12.1 0.2 2.5 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 EGE00342.1 - 0.00017 22.0 1.1 0.18 12.2 0.1 2.9 3 0 0 3 3 2 2 AAA ATPase domain AAA_21 PF13304.6 EGE00342.1 - 0.00021 21.2 4.4 0.87 9.3 1.1 4.2 3 1 1 4 4 4 1 AAA domain, putative AbiEii toxin, Type IV TA system DUF87 PF01935.17 EGE00342.1 - 0.00024 21.3 4.7 0.0073 16.4 0.4 3.1 3 0 0 3 3 3 1 Helicase HerA, central domain AAA_22 PF13401.6 EGE00342.1 - 0.00048 20.4 2.3 0.42 10.9 0.0 3.3 3 1 0 3 3 2 2 AAA domain RsgA_GTPase PF03193.16 EGE00342.1 - 0.0018 18.2 0.1 0.32 10.9 0.0 2.5 2 0 0 2 2 2 1 RsgA GTPase T2SSE PF00437.20 EGE00342.1 - 0.0027 16.8 0.5 0.61 9.1 0.0 2.7 3 0 0 3 3 3 1 Type II/IV secretion system protein MMR_HSR1 PF01926.23 EGE00342.1 - 0.0093 16.0 0.2 0.3 11.2 0.1 2.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_25 PF13481.6 EGE00342.1 - 0.014 15.0 0.0 3.6 7.1 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 EGE00342.1 - 0.024 14.4 0.3 0.17 11.6 0.0 2.6 4 0 0 4 4 3 0 AAA domain NB-ARC PF00931.22 EGE00342.1 - 0.026 13.7 0.1 8.1 5.5 0.0 3.1 3 0 0 3 3 3 0 NB-ARC domain SbcCD_C PF13558.6 EGE00342.1 - 0.027 14.7 0.4 32 4.8 0.0 3.8 4 0 0 4 4 3 0 Putative exonuclease SbcCD, C subunit AAA_10 PF12846.7 EGE00342.1 - 0.036 13.0 0.5 2.6 6.9 0.1 2.4 2 0 0 2 2 2 0 AAA-like domain AAA_33 PF13671.6 EGE00342.1 - 0.044 13.9 0.0 7.4 6.7 0.0 2.6 2 0 0 2 2 2 0 AAA domain MeaB PF03308.16 EGE00342.1 - 0.066 12.2 0.1 0.12 11.3 0.1 1.3 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB IstB_IS21 PF01695.17 EGE00342.1 - 0.077 12.7 0.5 17 5.1 0.0 3.0 3 0 0 3 3 3 0 IstB-like ATP binding protein AAA_18 PF13238.6 EGE00342.1 - 0.093 13.3 0.7 1.5 9.4 0.0 2.6 2 0 0 2 2 2 0 AAA domain FtsK_SpoIIIE PF01580.18 EGE00342.1 - 0.11 11.8 0.0 13 5.1 0.0 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_7 PF12775.7 EGE00342.1 - 0.11 11.9 0.2 9.2 5.7 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region CbiA PF01656.23 EGE00342.1 - 0.2 11.7 0.0 0.55 10.3 0.0 1.7 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain NACHT PF05729.12 EGE00342.1 - 0.42 10.5 4.0 25 4.7 0.0 3.7 3 0 0 3 3 3 0 NACHT domain AAA_5 PF07728.14 EGE00342.1 - 8.1 6.4 6.4 40 4.2 0.1 4.4 5 1 1 6 6 6 0 AAA domain (dynein-related subfamily) Myb_DNA-binding PF00249.31 EGE00344.1 - 2.5e-26 91.6 1.8 9.1e-15 54.6 0.1 2.8 3 0 0 3 3 3 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EGE00344.1 - 3.5e-18 65.6 7.5 5.6e-14 52.1 0.1 3.3 2 1 1 3 3 3 2 Myb-like DNA-binding domain HTH_23 PF13384.6 EGE00344.1 - 0.14 12.0 0.1 0.29 11.0 0.1 1.5 1 0 0 1 1 1 0 Homeodomain-like domain DUF2774 PF11242.8 EGE00344.1 - 0.15 12.3 0.0 0.29 11.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2774) RAB3GAP2_N PF14655.6 EGE00344.1 - 0.18 11.0 2.6 0.1 11.8 0.4 1.6 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Myb_DNA-bind_4 PF13837.6 EGE00344.1 - 0.47 10.9 0.0 0.47 10.9 0.0 2.9 3 0 0 3 3 3 0 Myb/SANT-like DNA-binding domain Glyco_transf_41 PF13844.6 EGE00347.1 - 1.4e-74 251.2 0.3 1.1e-51 175.8 0.0 2.3 1 1 1 2 2 2 2 Glycosyl transferase family 41 TPR_2 PF07719.17 EGE00347.1 - 3e-15 55.0 10.8 0.00098 19.1 0.2 6.2 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_11 PF13414.6 EGE00347.1 - 3.7e-15 55.3 12.7 0.0014 18.3 0.5 6.3 3 2 3 6 6 6 4 TPR repeat TPR_1 PF00515.28 EGE00347.1 - 2.8e-14 52.2 9.4 0.00088 19.0 0.0 6.3 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_8 PF13181.6 EGE00347.1 - 8.9e-09 34.9 9.2 0.035 14.3 0.1 5.9 6 0 0 6 6 5 3 Tetratricopeptide repeat TPR_14 PF13428.6 EGE00347.1 - 3.9e-07 30.4 5.1 0.04 14.8 0.0 5.7 3 2 2 5 5 5 2 Tetratricopeptide repeat TPR_17 PF13431.6 EGE00347.1 - 1.1e-06 28.6 5.4 3.2 8.3 0.0 5.8 5 1 1 6 6 6 3 Tetratricopeptide repeat TPR_16 PF13432.6 EGE00347.1 - 1.5e-06 28.8 9.2 0.21 12.3 0.3 4.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_10 PF13374.6 EGE00347.1 - 2.5e-06 27.2 14.4 0.43 10.5 0.7 6.1 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_12 PF13424.6 EGE00347.1 - 2.8e-06 27.5 9.1 0.19 12.1 0.2 5.5 3 2 1 5 5 5 3 Tetratricopeptide repeat ANAPC3 PF12895.7 EGE00347.1 - 3.9e-05 23.8 0.4 0.00053 20.2 0.0 2.6 2 0 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 EGE00347.1 - 4.3e-05 23.9 8.0 0.078 13.5 0.2 3.9 3 2 0 3 3 3 2 Tetratricopeptide repeat BTAD PF03704.17 EGE00347.1 - 0.00048 20.6 0.7 0.23 11.9 0.0 2.8 2 0 0 2 2 2 1 Bacterial transcriptional activator domain TPR_7 PF13176.6 EGE00347.1 - 0.0023 17.8 6.9 0.67 10.1 0.0 5.4 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_15 PF13429.6 EGE00347.1 - 0.032 13.5 2.8 2.4 7.3 0.0 3.3 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_9 PF13371.6 EGE00347.1 - 0.69 10.1 5.5 1.1 9.4 0.1 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat Ribosomal_L11_N PF03946.14 EGE00350.1 - 3.7e-23 81.1 0.2 5.9e-23 80.5 0.2 1.3 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Ribosomal_L11 PF00298.19 EGE00350.1 - 8.9e-15 55.0 0.0 1.5e-14 54.2 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain Sec23_trunk PF04811.15 EGE00351.1 - 7e-78 261.5 0.0 1e-77 261.0 0.0 1.2 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_BS PF08033.12 EGE00351.1 - 8.6e-29 100.1 0.0 1.7e-28 99.2 0.0 1.6 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain Sec23_helical PF04815.15 EGE00351.1 - 5.5e-25 87.2 0.2 1.4e-24 85.8 0.2 1.8 1 0 0 1 1 1 1 Sec23/Sec24 helical domain zf-Sec23_Sec24 PF04810.15 EGE00351.1 - 1.4e-14 53.8 4.5 2.6e-14 53.0 4.5 1.5 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 EGE00351.1 - 4.6e-11 42.5 0.0 1.2e-10 41.1 0.0 1.8 1 0 0 1 1 1 1 Gelsolin repeat Vps36-NZF-N PF16988.5 EGE00351.1 - 0.15 11.4 1.4 0.22 10.9 0.3 1.8 2 0 0 2 2 2 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain DNA_primase_lrg PF04104.14 EGE00352.1 - 5.9e-85 284.9 0.0 8.5e-85 284.4 0.0 1.2 1 0 0 1 1 1 1 Eukaryotic and archaeal DNA primase, large subunit Phage_head_chap PF11113.8 EGE00352.1 - 0.13 12.4 0.1 0.49 10.5 0.1 2.0 1 0 0 1 1 1 0 Head assembly gene product ADK PF00406.22 EGE00353.1 - 5.5e-36 123.9 0.0 5.8e-19 68.7 0.0 2.1 1 1 1 2 2 2 2 Adenylate kinase ADK_lid PF05191.14 EGE00353.1 - 2.5e-16 59.4 0.0 4e-16 58.7 0.0 1.4 1 0 0 1 1 1 1 Adenylate kinase, active site lid AAA_17 PF13207.6 EGE00353.1 - 3.2e-13 50.3 0.0 6.6e-12 46.0 0.0 2.3 2 1 0 2 2 2 1 AAA domain AAA_18 PF13238.6 EGE00353.1 - 7.3e-05 23.3 0.0 0.00031 21.3 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EGE00353.1 - 0.01 16.0 0.0 0.024 14.8 0.0 1.9 1 1 0 1 1 1 0 AAA domain MeaB PF03308.16 EGE00353.1 - 0.092 11.7 0.0 0.15 11.1 0.0 1.2 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_22 PF13401.6 EGE00353.1 - 0.13 12.5 0.0 0.22 11.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain SNase PF00565.17 EGE00354.1 - 1.7e-24 86.3 0.0 2.5e-24 85.8 0.0 1.2 1 0 0 1 1 1 1 Staphylococcal nuclease homologue Mito_carr PF00153.27 EGE00355.1 - 5e-58 193.0 2.1 5e-23 80.8 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF3147 PF11345.8 EGE00355.1 - 0.059 13.7 1.6 0.086 13.2 0.0 2.1 3 0 0 3 3 3 0 Protein of unknown function (DUF3147) PrcB_C PF14343.6 EGE00355.1 - 0.09 12.9 0.3 21 5.4 0.0 3.4 3 0 0 3 3 3 0 PrcB C-terminal Peptidase_C2 PF00648.21 EGE00356.1 - 5.8e-31 107.6 0.0 9e-31 107.0 0.0 1.2 1 0 0 1 1 1 1 Calpain family cysteine protease Calpain_III PF01067.22 EGE00356.1 - 3.4e-08 33.9 0.0 1.3e-05 25.4 0.0 3.2 2 1 0 2 2 2 1 Calpain large subunit, domain III MIT PF04212.18 EGE00356.1 - 0.044 13.8 0.5 0.08 13.0 0.5 1.4 1 0 0 1 1 1 0 MIT (microtubule interacting and transport) domain Vta1 PF04652.16 EGE00357.1 - 1.5e-55 187.1 6.8 1.5e-55 187.1 6.8 1.5 2 0 0 2 2 2 1 Vta1 like Vta1_C PF18097.1 EGE00357.1 - 1.9e-18 65.9 0.2 5.8e-18 64.3 0.2 1.9 1 0 0 1 1 1 1 Vta1 C-terminal domain Epimerase PF01370.21 EGE00361.1 - 4.2e-18 65.7 0.0 5.6e-18 65.3 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EGE00361.1 - 6.8e-08 31.8 0.0 2.6e-07 30.0 0.0 1.8 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 EGE00361.1 - 3.3e-07 29.7 0.0 4.8e-07 29.2 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_10 PF13460.6 EGE00361.1 - 0.00018 21.5 0.0 0.00028 20.9 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 EGE00361.1 - 0.0025 17.3 0.0 0.0035 16.8 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Sacchrp_dh_NADP PF03435.18 EGE00361.1 - 0.021 15.0 0.0 0.062 13.6 0.0 1.8 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Topoisom_I PF01028.20 EGE00362.1 - 2e-98 328.2 2.5 2e-98 328.2 2.5 2.8 3 1 1 4 4 4 1 Eukaryotic DNA topoisomerase I, catalytic core Topoisom_I_N PF02919.15 EGE00362.1 - 1.9e-96 321.7 1.7 1.9e-96 321.7 1.7 3.9 5 0 0 5 5 5 1 Eukaryotic DNA topoisomerase I, DNA binding fragment Topo_C_assoc PF14370.6 EGE00362.1 - 4.3e-16 58.6 5.8 4.9e-09 36.0 2.4 3.2 1 1 1 2 2 2 2 C-terminal topoisomerase domain ATP-synt PF00231.19 EGE00363.1 - 5.6e-77 259.2 3.1 6.8e-77 258.9 3.1 1.0 1 0 0 1 1 1 1 ATP synthase HNH_2 PF13391.6 EGE00365.1 - 0.0013 18.8 0.0 0.0032 17.6 0.0 1.7 1 0 0 1 1 1 1 HNH endonuclease Thioredoxin PF00085.20 EGE00366.1 - 1.3e-28 99.0 0.0 2.1e-24 85.5 0.0 2.4 2 0 0 2 2 2 2 Thioredoxin Thioredoxin_2 PF13098.6 EGE00366.1 - 2.6e-06 27.8 0.0 0.0028 18.1 0.1 2.8 1 1 1 2 2 2 2 Thioredoxin-like domain OST3_OST6 PF04756.13 EGE00366.1 - 4e-05 23.1 0.0 0.00022 20.7 0.0 1.9 2 0 0 2 2 2 1 OST3 / OST6 family, transporter family Thioredoxin_8 PF13905.6 EGE00366.1 - 0.0021 18.3 0.0 0.56 10.6 0.0 3.7 3 1 0 3 3 3 1 Thioredoxin-like AhpC-TSA PF00578.21 EGE00366.1 - 0.0046 16.9 0.0 0.051 13.5 0.0 2.5 3 0 0 3 3 3 1 AhpC/TSA family TraF PF13728.6 EGE00366.1 - 0.047 13.5 0.0 0.047 13.5 0.0 4.3 3 1 1 4 4 4 0 F plasmid transfer operon protein CCDC53 PF10152.9 EGE00366.1 - 6.4 7.2 17.0 1.2 9.6 1.1 2.3 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex GNAT_acetyltr_2 PF13718.6 EGE00367.1 - 3.2e-98 327.7 0.0 5.8e-98 326.8 0.0 1.5 1 0 0 1 1 1 1 GNAT acetyltransferase 2 tRNA_bind_2 PF13725.6 EGE00367.1 - 1.9e-91 306.0 0.0 3.4e-91 305.1 0.0 1.4 1 0 0 1 1 1 1 Possible tRNA binding domain Helicase_RecD PF05127.14 EGE00367.1 - 4.7e-65 218.7 0.0 1.3e-64 217.3 0.0 1.8 2 0 0 2 2 2 1 Helicase DUF1726 PF08351.11 EGE00367.1 - 5.9e-29 99.9 0.0 1.8e-28 98.3 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF1726) AAA_30 PF13604.6 EGE00367.1 - 0.00032 20.5 0.0 0.07 12.8 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 EGE00367.1 - 0.025 14.9 0.0 0.44 10.8 0.0 2.5 2 0 0 2 2 2 0 AAA domain Acetyltransf_1 PF00583.25 EGE00367.1 - 0.034 14.4 0.0 0.14 12.4 0.0 2.0 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family Glyco_transf_90 PF05686.12 EGE00368.1 - 1.6e-14 53.6 0.0 5.8e-07 28.8 0.0 3.3 2 1 0 2 2 2 2 Glycosyl transferase family 90 DUF2721 PF11026.8 EGE00368.1 - 0.27 11.1 0.0 0.27 11.1 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2721) Glyco_hydro_16 PF00722.21 EGE00369.1 - 3.4e-08 33.1 0.0 8e-08 32.0 0.0 1.6 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 Vps8 PF12816.7 EGE00370.1 - 4.4e-64 215.7 2.7 9.8e-64 214.5 0.3 2.3 2 0 0 2 2 2 1 Golgi CORVET complex core vacuolar protein 8 Clathrin PF00637.20 EGE00370.1 - 2e-07 31.0 8.8 0.00035 20.5 0.6 4.5 5 1 0 5 5 5 2 Region in Clathrin and VPS Pox_D3 PF04580.13 EGE00370.1 - 0.021 14.5 0.1 0.047 13.3 0.1 1.5 1 0 0 1 1 1 0 Chordopoxvirinae D3 protein Interferon PF00143.19 EGE00370.1 - 0.052 13.7 1.9 0.14 12.4 0.8 2.2 2 0 0 2 2 2 0 Interferon alpha/beta domain zf-C3H2C3 PF17122.5 EGE00370.1 - 0.13 12.3 0.1 0.13 12.3 0.1 1.9 2 0 0 2 2 2 0 Zinc-finger WD40 PF00400.32 EGE00370.1 - 0.15 12.9 1.2 0.4 11.6 0.1 2.5 2 0 0 2 2 2 0 WD domain, G-beta repeat RRN3 PF05327.11 EGE00372.1 - 0.33 9.5 4.9 0.54 8.7 4.9 1.3 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 RPEL PF02755.15 EGE00372.1 - 2.7 7.8 8.7 0.32 10.8 2.6 2.9 3 0 0 3 3 3 0 RPEL repeat DUF3606 PF12244.8 EGE00375.1 - 0.1 12.5 0.1 0.49 10.4 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3606) NYD-SP28_assoc PF14775.6 EGE00375.1 - 0.55 10.4 4.1 0.29 11.3 1.0 2.2 2 0 0 2 2 2 0 Sperm tail C-terminal domain NB-ARC PF00931.22 EGE00377.1 - 2.7e-19 69.4 0.0 5.2e-19 68.4 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain TPR_12 PF13424.6 EGE00377.1 - 3.8e-18 65.5 6.6 6.6e-08 32.7 0.0 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_10 PF13374.6 EGE00377.1 - 3.8e-08 32.9 5.0 0.0092 15.8 0.0 5.1 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_2 PF07719.17 EGE00377.1 - 1.7e-07 30.8 4.9 0.034 14.2 0.0 5.4 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_MalT PF17874.1 EGE00377.1 - 1.3e-06 28.1 3.8 1.3e-06 28.1 3.8 2.2 1 1 1 2 2 2 1 MalT-like TPR region TPR_8 PF13181.6 EGE00377.1 - 8.5e-06 25.6 4.4 1.2 9.6 0.0 5.1 5 0 0 5 5 5 1 Tetratricopeptide repeat AAA_16 PF13191.6 EGE00377.1 - 4.3e-05 24.0 0.7 0.003 18.0 0.7 2.6 1 1 0 1 1 1 1 AAA ATPase domain TPR_1 PF00515.28 EGE00377.1 - 5.7e-05 22.8 0.8 0.038 13.8 0.0 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat AAA_22 PF13401.6 EGE00377.1 - 0.00064 20.0 0.0 0.0015 18.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain TPR_19 PF14559.6 EGE00377.1 - 0.00067 20.1 2.7 3.1 8.4 0.0 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat SNAP PF14938.6 EGE00377.1 - 0.00076 19.0 0.3 0.0035 16.8 0.3 2.0 1 1 1 2 2 2 1 Soluble NSF attachment protein, SNAP TPR_6 PF13174.6 EGE00377.1 - 0.0024 18.4 2.5 2.3 9.0 0.0 4.3 4 0 0 4 4 3 1 Tetratricopeptide repeat ATPase_2 PF01637.18 EGE00377.1 - 0.034 14.1 0.0 0.073 13.0 0.0 1.6 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea TPR_11 PF13414.6 EGE00377.1 - 0.31 10.8 2.6 0.92 9.2 0.0 3.0 4 0 0 4 4 3 0 TPR repeat TPR_9 PF13371.6 EGE00377.1 - 0.34 11.1 1.5 0.76 10.0 0.2 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_16 PF13432.6 EGE00377.1 - 0.91 10.2 8.2 13 6.5 0.9 4.7 5 1 1 6 6 4 0 Tetratricopeptide repeat TPR_14 PF13428.6 EGE00377.1 - 6.2 7.9 11.6 54 5.0 0.0 5.9 6 1 1 7 7 6 0 Tetratricopeptide repeat DEAD PF00270.29 EGE00378.1 - 1.1e-40 139.3 1.2 2.2e-40 138.3 1.2 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EGE00378.1 - 3.5e-31 107.8 0.1 4.5e-30 104.3 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EGE00378.1 - 1.2e-07 31.9 0.0 3.3e-07 30.4 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit RIG-I_C PF18119.1 EGE00378.1 - 0.053 13.5 1.2 0.95 9.5 0.5 2.4 2 0 0 2 2 2 0 RIG-I receptor C-terminal domain Acyltransferase PF01553.21 EGE00380.1 - 4.1e-15 55.6 0.0 8.4e-15 54.6 0.0 1.5 1 1 0 1 1 1 1 Acyltransferase L31 PF09784.9 EGE00381.1 - 1.1e-44 151.0 0.4 1.3e-44 150.8 0.4 1.0 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L31 Pkinase PF00069.25 EGE00383.1 - 1.8e-19 70.2 0.0 6.4e-09 35.6 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EGE00383.1 - 1.6e-06 27.6 0.1 0.0043 16.4 0.0 2.6 3 0 0 3 3 3 2 Protein tyrosine kinase Kinase-like PF14531.6 EGE00383.1 - 0.071 12.4 0.7 4 6.7 0.0 2.5 3 0 0 3 3 3 0 Kinase-like DAG_kinase_N PF14513.6 EGE00385.1 - 0.12 12.6 2.2 0.21 11.8 2.2 1.3 1 0 0 1 1 1 0 Diacylglycerol kinase N-terminus bZIP_C PF12498.8 EGE00385.1 - 1.5 9.9 8.1 0.77 10.8 1.6 2.1 1 1 1 2 2 2 0 Basic leucine-zipper C terminal Annexin PF00191.20 EGE00386.1 - 5e-61 202.7 0.1 1.9e-17 63.1 0.0 4.1 4 0 0 4 4 4 4 Annexin DUF5617 PF18493.1 EGE00386.1 - 0.0002 21.4 3.0 0.11 12.6 0.8 2.5 1 1 0 2 2 2 2 Domain of unknown function (DUF5617) EBP PF05241.12 EGE00387.1 - 7.6e-63 211.2 3.3 9.2e-63 210.9 3.3 1.0 1 0 0 1 1 1 1 Emopamil binding protein HNH_2 PF13391.6 EGE00388.1 - 1.2e-14 54.1 0.1 2.8e-14 53.0 0.1 1.6 1 0 0 1 1 1 1 HNH endonuclease DUF4320 PF14208.6 EGE00389.1 - 0.1 12.6 0.4 3.3 7.8 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4320) zf-RING_UBOX PF13445.6 EGE00390.1 - 4.3e-08 33.0 5.8 4.3e-08 33.0 5.8 3.2 4 0 0 4 4 3 1 RING-type zinc-finger zf-C3HC4 PF00097.25 EGE00390.1 - 6.3e-08 32.4 5.3 6.3e-08 32.4 5.3 4.6 4 1 0 4 4 2 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EGE00390.1 - 3.3e-07 30.0 2.5 3.3e-07 30.0 2.5 4.4 5 1 0 5 5 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EGE00390.1 - 8e-06 26.1 6.9 8e-06 26.1 6.9 4.4 4 0 0 4 4 2 1 Ring finger domain zf-RING_6 PF14835.6 EGE00390.1 - 1.6e-05 24.7 0.7 1.6e-05 24.7 0.7 2.5 3 0 0 3 3 2 1 zf-RING of BARD1-type protein zf-RING_5 PF14634.6 EGE00390.1 - 3.1e-05 23.8 4.4 3.1e-05 23.8 4.4 4.7 4 0 0 4 4 4 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 EGE00390.1 - 0.00024 21.2 7.0 0.00024 21.2 7.0 3.8 3 0 0 3 3 3 1 zinc finger of C3HC4-type, RING SH3_9 PF14604.6 EGE00390.1 - 0.0014 18.4 0.1 0.0014 18.4 0.1 1.9 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.28 EGE00390.1 - 0.15 11.7 0.2 0.37 10.4 0.2 1.7 1 0 0 1 1 1 0 SH3 domain Spt20 PF12090.8 EGE00390.1 - 0.32 10.6 11.4 0.68 9.5 11.4 1.4 1 0 0 1 1 1 0 Spt20 family TERB2 PF15101.6 EGE00390.1 - 2.8 7.9 4.9 6.7 6.7 4.9 1.6 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Peptidase_M28 PF04389.17 EGE00396.1 - 4.7e-21 75.4 0.1 6.1e-21 75.0 0.1 1.1 1 0 0 1 1 1 1 Peptidase family M28 Mito_carr PF00153.27 EGE00397.1 - 2.6e-13 49.7 0.0 2.6e-06 27.3 0.0 2.2 2 0 0 2 2 2 2 Mitochondrial carrier protein CRIM PF16978.5 EGE00399.1 - 3.3e-43 147.2 0.0 5.9e-43 146.4 0.0 1.4 1 0 0 1 1 1 1 SAPK-interacting protein 1 (Sin1), middle CRIM domain SIN1_PH PF16979.5 EGE00399.1 - 1.8e-26 92.6 0.6 3.5e-26 91.6 0.6 1.5 1 0 0 1 1 1 1 SAPK-interacting protein 1 (Sin1), Pleckstrin-homology TUG-UBL1 PF11470.8 EGE00399.1 - 0.0094 16.2 0.1 0.02 15.1 0.1 1.5 1 0 0 1 1 1 1 TUG ubiquitin-like domain Pkinase PF00069.25 EGE00400.1 - 2.4e-72 243.5 0.0 3.9e-72 242.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGE00400.1 - 1.1e-36 126.5 0.0 1.6e-36 125.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EGE00400.1 - 2.6e-07 30.3 0.0 3.9e-07 29.7 0.0 1.3 1 0 0 1 1 1 1 Kinase-like YrbL-PhoP_reg PF10707.9 EGE00400.1 - 0.052 13.1 0.7 1.2 8.6 0.0 2.2 2 0 0 2 2 2 0 PhoP regulatory network protein YrbL Seadorna_VP7 PF07387.11 EGE00400.1 - 0.059 12.4 0.0 0.1 11.6 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 APH PF01636.23 EGE00400.1 - 0.15 12.0 1.2 0.25 11.2 0.0 2.0 3 0 0 3 3 3 0 Phosphotransferase enzyme family TFIIA PF03153.13 EGE00400.1 - 0.59 10.1 20.5 0.8 9.6 20.5 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit zf-Tim10_DDP PF02953.15 EGE00401.1 - 3.5e-22 77.8 3.7 5.1e-22 77.3 3.7 1.2 1 0 0 1 1 1 1 Tim10/DDP family zinc finger DUF3475 PF11961.8 EGE00401.1 - 0.026 14.6 0.3 0.21 11.7 0.0 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF3475) Lectin_leg-like PF03388.13 EGE00402.1 - 2e-61 207.3 0.0 2.7e-61 206.8 0.0 1.1 1 0 0 1 1 1 1 Legume-like lectin family Bact_lectin PF18483.1 EGE00402.1 - 1e-06 28.9 0.0 1.6e-06 28.3 0.0 1.2 1 0 0 1 1 1 1 Bacterial lectin Lectin_legB PF00139.19 EGE00402.1 - 6.3e-05 22.6 0.0 0.043 13.4 0.0 2.2 2 0 0 2 2 2 2 Legume lectin domain BRF1 PF07741.13 EGE00403.1 - 0.014 15.8 17.0 0.082 13.3 10.1 2.9 2 1 0 2 2 2 0 Brf1-like TBP-binding domain PRCC PF10253.9 EGE00404.1 - 1.8e-36 127.0 5.2 1.8e-36 127.0 5.2 3.7 2 2 0 2 2 2 1 Mitotic checkpoint regulator, MAD2B-interacting HNH_2 PF13391.6 EGE00405.1 - 4.5e-15 55.5 0.1 8.7e-15 54.6 0.1 1.5 1 0 0 1 1 1 1 HNH endonuclease ATP-grasp_3 PF02655.14 EGE00406.1 - 9.8e-09 35.4 0.0 1.5e-08 34.8 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_4 PF13535.6 EGE00406.1 - 1.2e-06 28.3 0.0 2.5e-06 27.2 0.0 1.5 1 1 0 1 1 1 1 ATP-grasp domain CPSase_L_D2 PF02786.17 EGE00406.1 - 0.2 11.1 0.0 0.34 10.4 0.0 1.4 1 0 0 1 1 1 0 Carbamoyl-phosphate synthase L chain, ATP binding domain AAA_5 PF07728.14 EGE00407.1 - 8.1e-133 437.3 0.0 7.5e-24 84.3 0.0 10.1 9 0 0 9 9 9 9 AAA domain (dynein-related subfamily) AAA_lid_7 PF17867.1 EGE00407.1 - 6.9e-52 174.1 5.2 1e-20 73.9 0.0 5.9 5 0 0 5 5 5 4 Midasin AAA lid domain AAA PF00004.29 EGE00407.1 - 1.2e-30 106.6 0.0 0.00018 22.0 0.0 6.9 6 0 0 6 6 6 6 ATPase family associated with various cellular activities (AAA) AAA_lid_5 PF17865.1 EGE00407.1 - 3.4e-30 104.3 0.2 2e-29 101.8 0.0 2.5 3 0 0 3 3 1 1 Midasin AAA lid domain AAA_7 PF12775.7 EGE00407.1 - 4.5e-30 104.5 0.6 4.6e-05 23.0 0.0 6.9 7 0 0 7 7 7 6 P-loop containing dynein motor region AAA_3 PF07726.11 EGE00407.1 - 2.6e-29 101.7 0.0 5.8e-10 39.1 0.0 7.4 7 0 0 7 7 7 4 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EGE00407.1 - 5.4e-27 95.2 12.3 9.8e-05 22.8 0.1 8.7 7 1 0 7 7 6 6 AAA ATPase domain Dynein_heavy PF03028.15 EGE00407.1 - 3e-20 72.5 0.4 1.9e-05 24.7 0.0 8.0 8 1 0 8 8 6 4 Dynein heavy chain region D6 P-loop domain Sigma54_activat PF00158.26 EGE00407.1 - 2.6e-19 69.5 0.0 0.02 14.6 0.0 6.5 6 0 0 6 6 6 5 Sigma-54 interaction domain AAA_6 PF12774.7 EGE00407.1 - 7.9e-19 67.8 0.0 0.0039 16.2 0.0 8.2 8 1 0 8 8 7 3 Hydrolytic ATP binding site of dynein motor region AAA_22 PF13401.6 EGE00407.1 - 1.5e-18 67.4 0.8 0.077 13.3 0.0 8.4 7 0 0 7 7 7 4 AAA domain TsaE PF02367.17 EGE00407.1 - 7e-17 61.6 0.9 0.08 12.9 0.0 6.8 6 0 0 6 6 6 4 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_18 PF13238.6 EGE00407.1 - 5.9e-15 56.0 0.2 0.63 10.6 0.0 7.1 6 0 0 6 6 6 3 AAA domain AAA_33 PF13671.6 EGE00407.1 - 2.3e-14 53.8 0.2 0.4 10.8 0.0 6.8 6 0 0 6 6 6 3 AAA domain AAA_30 PF13604.6 EGE00407.1 - 3e-14 53.2 0.1 0.051 13.3 0.0 7.6 7 1 0 7 7 6 1 AAA domain Mg_chelatase PF01078.21 EGE00407.1 - 9.3e-14 51.3 5.8 0.83 9.0 0.0 9.0 8 1 0 9 9 9 2 Magnesium chelatase, subunit ChlI AAA_14 PF13173.6 EGE00407.1 - 1.8e-13 50.7 0.0 0.0015 18.6 0.0 7.8 9 0 0 9 9 6 2 AAA domain ABC_tran PF00005.27 EGE00407.1 - 5.1e-13 49.7 6.6 0.039 14.4 0.0 7.3 7 0 0 7 7 6 3 ABC transporter RuvB_N PF05496.12 EGE00407.1 - 3.6e-12 46.3 3.3 0.18 11.5 0.0 6.6 7 0 0 7 7 6 4 Holliday junction DNA helicase RuvB P-loop domain NACHT PF05729.12 EGE00407.1 - 1.2e-11 44.8 5.5 0.15 12.0 0.1 7.1 6 0 0 6 6 6 2 NACHT domain RNA_helicase PF00910.22 EGE00407.1 - 4.9e-11 43.0 0.2 1.4 9.3 0.0 6.7 6 0 0 6 6 6 1 RNA helicase AAA_19 PF13245.6 EGE00407.1 - 1.4e-10 41.7 2.0 4 7.8 0.1 6.8 6 0 0 6 6 6 0 AAA domain Sigma54_activ_2 PF14532.6 EGE00407.1 - 9.4e-10 38.7 5.6 0.045 13.9 0.0 6.8 7 0 0 7 7 7 2 Sigma-54 interaction domain Rad17 PF03215.15 EGE00407.1 - 9.7e-10 38.7 0.9 0.057 13.3 0.0 6.2 6 0 0 6 6 6 1 Rad17 P-loop domain Zeta_toxin PF06414.12 EGE00407.1 - 2.1e-09 36.9 3.7 0.027 13.7 0.0 6.9 7 0 0 7 7 7 1 Zeta toxin IstB_IS21 PF01695.17 EGE00407.1 - 6e-09 35.9 0.0 2.4 7.9 0.0 6.3 6 0 0 6 6 6 1 IstB-like ATP binding protein SRP54 PF00448.22 EGE00407.1 - 1.1e-08 35.0 2.9 1.2 8.7 0.1 5.9 6 0 0 6 6 6 2 SRP54-type protein, GTPase domain AAA_29 PF13555.6 EGE00407.1 - 1.8e-08 34.0 0.3 2.3 8.0 0.0 6.6 6 0 0 6 6 6 1 P-loop containing region of AAA domain AAA_28 PF13521.6 EGE00407.1 - 4.2e-08 33.6 4.2 0.46 10.7 0.0 6.2 6 0 0 6 6 6 2 AAA domain PduV-EutP PF10662.9 EGE00407.1 - 5.3e-08 32.7 1.2 0.32 10.7 0.0 6.1 6 0 0 6 6 6 1 Ethanolamine utilisation - propanediol utilisation DUF815 PF05673.13 EGE00407.1 - 8.5e-08 31.7 9.2 1.1 8.4 0.2 6.4 7 0 0 7 7 6 2 Protein of unknown function (DUF815) T2SSE PF00437.20 EGE00407.1 - 1.1e-07 31.2 0.4 0.12 11.4 0.0 4.9 5 0 0 5 5 5 1 Type II/IV secretion system protein AAA_24 PF13479.6 EGE00407.1 - 3.9e-07 30.0 0.0 5.3 6.7 0.0 6.3 6 0 0 6 6 6 0 AAA domain RsgA_GTPase PF03193.16 EGE00407.1 - 1e-06 28.8 7.8 1.2 9.0 0.5 6.0 6 0 0 6 6 6 1 RsgA GTPase Roc PF08477.13 EGE00407.1 - 1.1e-06 28.9 2.8 11 6.2 0.0 6.3 6 0 0 6 6 6 0 Ras of Complex, Roc, domain of DAPkinase ATPase_2 PF01637.18 EGE00407.1 - 1.2e-06 28.6 0.0 18 5.1 0.0 6.0 6 0 0 6 6 6 0 ATPase domain predominantly from Archaea AAA_25 PF13481.6 EGE00407.1 - 1.4e-06 28.1 7.0 2.8 7.5 0.0 6.3 7 0 0 7 7 5 1 AAA domain TIP49 PF06068.13 EGE00407.1 - 1.8e-06 27.5 1.9 1.1 8.4 0.0 5.1 5 0 0 5 5 5 1 TIP49 P-loop domain TniB PF05621.11 EGE00407.1 - 2.1e-06 27.3 0.1 7.8 5.9 0.0 5.6 6 0 0 6 6 5 0 Bacterial TniB protein MCM PF00493.23 EGE00407.1 - 1e-05 24.7 0.0 2.9 6.9 0.0 4.8 5 0 0 5 5 5 1 MCM P-loop domain ResIII PF04851.15 EGE00407.1 - 1.4e-05 25.2 0.1 2.3 8.2 0.0 5.4 5 0 0 5 5 5 1 Type III restriction enzyme, res subunit Bac_DnaA PF00308.18 EGE00407.1 - 5.8e-05 23.0 0.0 5.8 6.7 0.0 4.6 5 0 0 5 5 4 0 Bacterial dnaA protein DnaB_C PF03796.15 EGE00407.1 - 0.00047 19.6 1.1 1.1 8.5 0.0 4.2 4 0 0 4 4 4 1 DnaB-like helicase C terminal domain NTPase_1 PF03266.15 EGE00407.1 - 0.00077 19.4 6.2 1.4 8.8 0.0 5.2 6 0 0 6 6 4 1 NTPase AAA_17 PF13207.6 EGE00407.1 - 0.00096 19.6 1.5 13 6.2 0.0 4.7 4 0 0 4 4 4 0 AAA domain CPT PF07931.12 EGE00407.1 - 0.0017 18.2 2.1 1.5 8.6 0.0 5.2 6 1 0 6 6 4 1 Chloramphenicol phosphotransferase-like protein ATPase PF06745.13 EGE00407.1 - 0.002 17.5 0.1 14 4.9 0.0 4.6 4 0 0 4 4 4 0 KaiC Viral_helicase1 PF01443.18 EGE00407.1 - 0.0051 16.6 0.1 14 5.3 0.0 5.0 5 0 0 5 5 5 0 Viral (Superfamily 1) RNA helicase GAF_2 PF13185.6 EGE00407.1 - 0.012 15.9 0.0 0.043 14.1 0.0 2.0 1 0 0 1 1 1 0 GAF domain MMR_HSR1 PF01926.23 EGE00407.1 - 0.016 15.3 3.1 55 3.9 0.0 6.0 6 0 0 6 6 6 0 50S ribosome-binding GTPase PhoH PF02562.16 EGE00407.1 - 0.041 13.3 0.8 22 4.4 0.0 4.3 5 0 0 5 5 5 0 PhoH-like protein CbiA PF01656.23 EGE00407.1 - 0.069 13.2 0.5 13 5.9 0.1 3.9 4 0 0 4 4 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain Ploopntkinase3 PF18751.1 EGE00407.1 - 0.12 12.2 0.1 57 3.6 0.0 3.6 4 0 0 4 4 4 0 P-loop Nucleotide Kinase3 dNK PF01712.19 EGE00407.1 - 0.14 12.0 2.3 6.4 6.6 0.0 3.7 4 0 0 4 4 3 0 Deoxynucleoside kinase AAA_8 PF12780.7 EGE00407.1 - 0.26 10.6 9.8 31 3.8 0.0 6.4 8 0 0 8 8 7 0 P-loop containing dynein motor region D4 ATP_bind_1 PF03029.17 EGE00407.1 - 0.42 10.3 11.0 20 4.9 0.1 5.9 7 0 0 7 7 5 0 Conserved hypothetical ATP binding protein cobW PF02492.19 EGE00407.1 - 0.59 9.7 8.2 27 4.3 0.0 4.9 6 0 0 6 6 5 0 CobW/HypB/UreG, nucleotide-binding domain Ras PF00071.22 EGE00407.1 - 1 9.0 3.0 71 3.0 0.0 4.3 5 0 0 5 5 5 0 Ras family KTI12 PF08433.10 EGE00407.1 - 1.2 8.5 5.5 69 2.8 0.2 4.8 5 0 0 5 5 5 0 Chromatin associated protein KTI12 Voltage_CLC PF00654.20 EGE00408.1 - 2.9e-86 289.9 19.8 2.9e-86 289.9 19.8 1.6 2 0 0 2 2 2 1 Voltage gated chloride channel Pox_L5 PF04872.13 EGE00409.1 - 0.075 12.9 0.1 0.2 11.6 0.1 1.7 1 0 0 1 1 1 0 Poxvirus L5 protein family Trypan_PARP PF05887.11 EGE00410.1 - 0.002 18.1 56.4 0.004 17.1 24.9 12.0 8 3 4 12 12 12 2 Procyclic acidic repetitive protein (PARP) HMG_box PF00505.19 EGE00411.1 - 1.7e-06 28.3 4.0 1.7e-06 28.3 4.0 2.7 2 1 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EGE00411.1 - 2.1e-05 25.0 3.3 2.1e-05 25.0 3.3 2.8 3 0 0 3 3 3 1 HMG-box domain Protamine_like PF06382.11 EGE00411.1 - 0.0051 17.0 1.1 0.0051 17.0 1.1 2.2 2 0 0 2 2 2 1 Protamine and protamine like DUF4662 PF15578.6 EGE00411.1 - 0.041 13.7 11.6 0.13 12.0 4.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4662) DEAD PF00270.29 EGE00412.1 - 3.2e-49 167.1 0.0 9.9e-49 165.5 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EGE00412.1 - 1e-26 93.4 0.0 3.5e-26 91.7 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EGE00412.1 - 0.0031 17.5 0.0 0.021 14.8 0.0 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit WLM PF08325.10 EGE00413.1 - 0.0022 18.1 0.2 0.0022 18.1 0.2 1.4 2 0 0 2 2 2 1 WLM domain zf-C2H2 PF00096.26 EGE00414.1 - 9.9e-21 73.0 52.0 8.4e-07 29.1 0.9 8.6 8 0 0 8 8 8 6 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EGE00414.1 - 5.3e-14 51.9 45.5 6e-08 32.8 0.8 7.4 7 0 0 7 7 7 4 Zinc-finger double domain zf-met PF12874.7 EGE00414.1 - 3.9e-13 49.3 4.8 0.00036 20.8 0.3 5.6 4 0 0 4 4 4 3 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.6 EGE00414.1 - 9.9e-12 44.7 51.5 0.00032 21.3 0.6 8.4 8 0 0 8 8 7 4 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EGE00414.1 - 1.1e-08 35.1 12.8 0.0046 17.2 0.3 5.6 5 0 0 5 5 4 2 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.5 EGE00414.1 - 2.6e-06 27.1 6.0 0.072 12.9 0.2 4.7 4 0 0 4 4 4 2 zinc-finger C2H2-type zf-C2H2_6 PF13912.6 EGE00414.1 - 9e-06 25.6 20.4 0.00046 20.1 0.8 5.7 5 0 0 5 5 5 2 C2H2-type zinc finger zf-C2HC_2 PF13913.6 EGE00414.1 - 0.00041 20.2 10.7 0.17 11.8 0.2 4.9 4 0 0 4 4 4 1 zinc-finger of a C2HC-type zf_UBZ PF18439.1 EGE00414.1 - 0.00077 19.0 1.7 6.1 6.5 0.1 3.9 3 0 0 3 3 3 1 Ubiquitin-Binding Zinc Finger zf-Di19 PF05605.12 EGE00414.1 - 0.019 15.2 16.5 0.047 14.0 0.5 4.2 4 0 0 4 4 3 0 Drought induced 19 protein (Di19), zinc-binding FOXP-CC PF16159.5 EGE00414.1 - 0.022 15.4 0.2 0.022 15.4 0.2 7.6 5 4 2 7 7 6 0 FOXP coiled-coil domain BolA PF01722.18 EGE00414.1 - 0.28 11.5 6.9 0.76 10.1 0.1 3.5 3 1 1 4 4 3 0 BolA-like protein zf_ZIC PF18366.1 EGE00414.1 - 4.1 7.6 9.5 3.6 7.8 0.0 3.4 4 0 0 4 4 3 0 Zic proteins zinc finger domain DUF533 PF04391.12 EGE00415.1 - 0.15 11.7 0.3 0.26 10.8 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF533) zf-C2H2 PF00096.26 EGE00416.1 - 2.1e-06 27.9 12.8 3.9e-05 23.9 3.5 2.9 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EGE00416.1 - 5.6e-06 26.5 3.2 5.6e-06 26.5 3.2 3.6 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 EGE00416.1 - 0.0018 19.0 1.9 0.0018 19.0 1.9 3.2 3 0 0 3 3 3 1 C2H2-type zinc finger zf-met PF12874.7 EGE00416.1 - 0.0019 18.5 0.9 0.0019 18.5 0.9 3.8 4 0 0 4 4 4 1 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 EGE00416.1 - 0.0056 16.6 3.1 0.0068 16.4 0.6 2.4 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EGE00416.1 - 0.014 15.7 0.9 0.047 14.0 0.9 1.9 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding DUF2225 PF09986.9 EGE00416.1 - 0.02 14.6 0.1 0.032 13.9 0.1 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2225) IBR PF01485.21 EGE00416.1 - 0.058 13.6 1.8 0.12 12.7 1.8 1.4 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain zf-Di19 PF05605.12 EGE00416.1 - 0.064 13.6 5.6 0.15 12.4 5.6 1.7 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding Podoplanin PF05808.11 EGE00420.1 - 0.028 14.5 3.1 0.088 12.9 3.1 1.9 1 1 0 1 1 1 0 Podoplanin SKG6 PF08693.10 EGE00420.1 - 2.7 7.5 4.1 5.1 6.6 4.1 1.4 1 0 0 1 1 1 0 Transmembrane alpha-helix domain TPR_14 PF13428.6 EGE00421.1 - 6.1e-12 45.3 19.2 0.078 13.8 0.0 8.8 5 1 6 11 11 11 4 Tetratricopeptide repeat TPR_19 PF14559.6 EGE00421.1 - 1.5e-11 44.6 1.3 0.037 14.5 0.2 5.3 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_17 PF13431.6 EGE00421.1 - 3.8e-07 30.0 0.1 0.45 11.0 0.0 5.9 8 0 0 8 8 8 2 Tetratricopeptide repeat HAT PF02184.16 EGE00421.1 - 9.4e-07 28.7 56.9 8.2e-05 22.5 1.8 10.7 11 0 0 11 11 11 4 HAT (Half-A-TPR) repeat TPR_8 PF13181.6 EGE00421.1 - 4.6e-06 26.4 4.6 9.2 6.8 0.0 7.4 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_6 PF13174.6 EGE00421.1 - 0.011 16.3 14.9 16 6.4 0.0 6.9 7 0 0 7 7 6 0 Tetratricopeptide repeat U3_assoc_6 PF08640.11 EGE00421.1 - 0.038 14.0 29.3 0.047 13.8 2.6 6.4 5 2 1 7 7 7 0 U3 small nucleolar RNA-associated protein 6 TPR_2 PF07719.17 EGE00421.1 - 0.091 12.9 15.6 0.86 9.9 0.0 6.7 9 0 0 9 9 9 0 Tetratricopeptide repeat ER PF01133.17 EGE00421.1 - 0.14 12.2 1.4 3.7 7.6 0.5 3.4 2 1 1 3 3 3 0 Enhancer of rudimentary TPR_16 PF13432.6 EGE00421.1 - 0.16 12.6 9.3 12 6.7 0.0 5.3 7 0 0 7 7 6 0 Tetratricopeptide repeat TPR_12 PF13424.6 EGE00421.1 - 0.23 11.8 15.4 0.24 11.7 1.5 5.8 5 2 0 5 5 5 0 Tetratricopeptide repeat Nop PF01798.18 EGE00422.1 - 3.7e-71 239.3 0.0 5.7e-71 238.6 0.0 1.3 1 0 0 1 1 1 1 snoRNA binding domain, fibrillarin Prp31_C PF09785.9 EGE00422.1 - 4.6e-47 159.9 1.6 9.3e-47 158.9 1.6 1.6 1 0 0 1 1 1 1 Prp31 C terminal domain eIF-3c_N PF05470.12 EGE00422.1 - 0.055 11.8 0.6 0.079 11.3 0.6 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus RRN3 PF05327.11 EGE00422.1 - 2.4 6.6 7.1 3.3 6.1 7.1 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 AdoHcyase PF05221.17 EGE00423.1 - 3e-129 430.4 0.0 1.1e-73 248.0 0.2 2.0 1 1 1 2 2 2 2 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.21 EGE00423.1 - 2.6e-84 281.2 2.2 5.5e-84 280.1 2.2 1.6 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.19 EGE00423.1 - 4.1e-07 29.5 0.1 8.1e-07 28.6 0.1 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.12 EGE00423.1 - 0.00011 21.9 0.2 0.00019 21.1 0.2 1.4 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain TrkA_N PF02254.18 EGE00423.1 - 0.0018 18.5 0.1 0.0048 17.1 0.1 1.7 1 0 0 1 1 1 1 TrkA-N domain DUF3759 PF12585.8 EGE00424.1 - 5.7e-38 128.8 9.3 6.7e-38 128.6 9.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3759) DUF776 PF05604.11 EGE00425.1 - 0.083 13.3 0.3 0.15 12.4 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF776) Band_7 PF01145.25 EGE00426.1 - 6.2e-30 104.5 0.8 6.2e-30 104.5 0.8 1.6 2 0 0 2 2 2 1 SPFH domain / Band 7 family Band_7_C PF16200.5 EGE00426.1 - 4e-23 81.2 1.6 4e-23 81.2 1.6 2.1 2 0 0 2 2 2 1 C-terminal region of band_7 Pox_A11 PF05061.13 EGE00426.1 - 0.02 14.2 0.5 0.031 13.6 0.5 1.3 1 0 0 1 1 1 0 Poxvirus A11 Protein Band_7_1 PF13421.6 EGE00426.1 - 0.07 12.8 0.0 0.12 12.0 0.0 1.4 1 0 0 1 1 1 0 SPFH domain-Band 7 family RecX PF02631.16 EGE00426.1 - 0.092 13.2 2.7 0.11 13.0 0.7 2.2 2 1 1 3 3 3 0 RecX family Mod_r PF07200.13 EGE00430.1 - 1.9e-25 89.7 0.5 2.3e-25 89.4 0.5 1.1 1 0 0 1 1 1 1 Modifier of rudimentary (Mod(r)) protein GIT_CC PF16559.5 EGE00430.1 - 0.069 13.0 0.5 0.13 12.1 0.5 1.4 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor PSK_trans_fac PF07704.11 EGE00430.1 - 0.21 12.4 1.8 0.55 11.0 1.8 1.6 1 0 0 1 1 1 0 Rv0623-like transcription factor Cortex-I_coil PF09304.10 EGE00430.1 - 0.71 10.1 3.6 0.36 11.0 1.1 1.7 2 0 0 2 2 2 0 Cortexillin I, coiled coil APG6_N PF17675.1 EGE00430.1 - 1.7 9.2 5.0 0.33 11.5 0.8 1.8 2 0 0 2 2 2 0 Apg6 coiled-coil region PAP2 PF01569.21 EGE00431.1 - 6.6e-25 87.4 0.2 6.6e-25 87.4 0.2 1.9 2 1 0 2 2 2 1 PAP2 superfamily Cupin_2 PF07883.11 EGE00433.1 - 0.14 11.9 0.2 0.2 11.4 0.2 1.2 1 0 0 1 1 1 0 Cupin domain Aldo_ket_red PF00248.21 EGE00434.1 - 4.2e-50 170.6 0.1 6.9e-50 169.9 0.1 1.3 1 0 0 1 1 1 1 Aldo/keto reductase family GFA PF04828.14 EGE00435.1 - 2.2e-07 31.1 0.2 3.6e-07 30.4 0.2 1.4 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme CHCH PF06747.13 EGE00436.1 - 0.00015 21.8 0.4 0.00024 21.2 0.4 1.4 1 0 0 1 1 1 1 CHCH domain COX17 PF05051.13 EGE00436.1 - 0.0072 16.7 1.7 0.36 11.2 0.1 2.2 1 1 1 2 2 2 2 Cytochrome C oxidase copper chaperone (COX17) Pet191_N PF10203.9 EGE00436.1 - 0.02 15.2 1.7 0.03 14.6 0.7 1.6 1 1 1 2 2 2 0 Cytochrome c oxidase assembly protein PET191 NPR3 PF03666.13 EGE00437.1 - 1.5e-151 505.4 1.4 1.1e-149 499.2 0.0 2.1 2 0 0 2 2 2 1 Nitrogen Permease regulator of amino acid transport activity 3 VPS38 PF17649.1 EGE00437.1 - 0.028 13.3 0.2 0.079 11.8 0.0 1.8 3 0 0 3 3 3 0 Vacuolar protein sorting 38 NPR2 PF06218.11 EGE00437.1 - 0.081 11.7 0.0 0.16 10.7 0.0 1.4 1 0 0 1 1 1 0 Nitrogen permease regulator 2 Mago-bind PF09282.10 EGE00437.1 - 0.27 11.1 3.8 0.97 9.4 3.8 1.9 1 0 0 1 1 1 0 Mago binding Hepatitis_core PF00906.20 EGE00437.1 - 2.1 7.9 5.2 5.3 6.5 4.4 1.9 2 0 0 2 2 2 0 Hepatitis core antigen Presenilin PF01080.17 EGE00437.1 - 6.5 5.4 7.9 1.1 8.0 2.9 1.9 2 0 0 2 2 2 0 Presenilin Myc_N PF01056.18 EGE00437.1 - 6.6 6.5 12.2 1.8 8.4 1.8 2.8 3 0 0 3 3 3 0 Myc amino-terminal region BORG_CEP PF14957.6 EGE00437.1 - 8.8 7.5 8.5 11 7.1 3.2 2.9 3 0 0 3 3 3 0 Cdc42 effector La PF05383.17 EGE00438.1 - 2.1e-19 69.3 0.3 3.7e-19 68.5 0.3 1.3 1 0 0 1 1 1 1 La domain Ank_5 PF13857.6 EGE00439.1 - 1.5e-12 47.5 0.4 1.3e-10 41.4 0.2 2.5 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 EGE00439.1 - 1.2e-10 41.7 0.0 1.8e-08 34.8 0.0 2.4 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 EGE00439.1 - 1.2e-08 35.4 0.3 2.8e-08 34.3 0.2 1.7 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EGE00439.1 - 9.4e-07 28.7 0.1 3.7e-05 23.8 0.1 2.9 2 1 0 2 2 2 1 Ankyrin repeat Ank PF00023.30 EGE00439.1 - 0.00054 20.3 0.0 0.011 16.1 0.2 2.6 2 0 0 2 2 2 1 Ankyrin repeat YejG PF13989.6 EGE00439.1 - 0.08 13.4 0.0 0.12 12.8 0.0 1.4 1 0 0 1 1 1 0 YejG-like protein RNA_lig_T4_1 PF09511.10 EGE00440.1 - 9.8e-77 257.7 0.1 6.7e-76 255.0 0.0 2.3 3 0 0 3 3 3 1 RNA ligase tRNA_lig_CPD PF08302.11 EGE00440.1 - 1.2e-62 211.6 9.1 1.5e-61 208.1 5.7 2.2 1 1 1 2 2 2 2 Fungal tRNA ligase phosphodiesterase domain tRNA_lig_kinase PF08303.11 EGE00440.1 - 7.6e-47 159.5 0.3 2.2e-46 158.0 0.1 1.9 2 0 0 2 2 2 1 tRNA ligase kinase domain AAA_23 PF13476.6 EGE00440.1 - 0.0011 19.5 0.6 0.0026 18.3 0.6 1.6 1 0 0 1 1 1 1 AAA domain CotH PF08757.11 EGE00440.1 - 0.003 17.1 0.2 0.003 17.1 0.2 1.8 2 0 0 2 2 2 1 CotH kinase protein Tim54 PF11711.8 EGE00440.1 - 0.0095 14.8 1.2 0.015 14.1 1.2 1.2 1 0 0 1 1 1 1 Inner membrane protein import complex subunit Tim54 SUIM_assoc PF16619.5 EGE00440.1 - 0.035 14.2 7.2 0.032 14.3 2.3 2.4 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 AAA_18 PF13238.6 EGE00440.1 - 0.045 14.3 2.8 0.21 12.1 0.1 3.3 3 1 0 3 3 3 0 AAA domain LPP20 PF02169.16 EGE00440.1 - 0.93 9.9 5.0 0.34 11.3 0.7 2.3 3 0 0 3 3 3 0 LPP20 lipoprotein UL42 PF17638.2 EGE00441.1 - 0.028 14.4 1.1 0.028 14.4 1.1 2.2 1 1 1 2 2 2 0 HCMV UL42 LRR_8 PF13855.6 EGE00442.1 - 0.29 10.9 2.1 0.42 10.4 0.2 2.3 2 0 0 2 2 2 0 Leucine rich repeat Macoilin PF09726.9 EGE00442.1 - 6.5 5.2 5.3 9.2 4.7 5.3 1.1 1 0 0 1 1 1 0 Macoilin family AAA PF00004.29 EGE00443.1 - 1.4e-40 138.8 0.0 3.5e-40 137.5 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 EGE00443.1 - 9.8e-19 67.1 0.2 2e-18 66.1 0.2 1.6 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_lid_3 PF17862.1 EGE00443.1 - 4.8e-09 35.9 0.0 1.3e-08 34.5 0.0 1.8 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 EGE00443.1 - 8.5e-05 23.0 1.9 0.014 15.8 0.0 2.9 2 1 1 3 3 3 1 AAA ATPase domain AAA_5 PF07728.14 EGE00443.1 - 0.00019 21.4 1.6 0.00072 19.6 0.1 2.6 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 EGE00443.1 - 0.0003 20.6 0.0 0.00072 19.3 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 EGE00443.1 - 0.0025 18.0 2.5 0.006 16.7 0.0 2.8 2 2 0 2 2 2 1 AAA domain (Cdc48 subfamily) PhoH PF02562.16 EGE00443.1 - 0.0027 17.2 1.1 0.073 12.5 0.1 2.7 3 0 0 3 3 3 1 PhoH-like protein DUF815 PF05673.13 EGE00443.1 - 0.0029 16.8 1.3 0.051 12.7 0.0 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_22 PF13401.6 EGE00443.1 - 0.0053 17.0 4.6 0.084 13.1 0.0 3.2 3 1 1 4 4 4 1 AAA domain Mg_chelatase PF01078.21 EGE00443.1 - 0.008 15.6 0.1 0.024 14.0 0.0 1.8 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_33 PF13671.6 EGE00443.1 - 0.011 15.8 0.0 0.036 14.2 0.0 2.0 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 EGE00443.1 - 0.067 12.9 0.1 0.16 11.7 0.1 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_7 PF12775.7 EGE00443.1 - 0.098 12.2 0.3 0.49 9.9 0.0 2.3 2 1 0 2 2 2 0 P-loop containing dynein motor region Parvo_NS1 PF01057.17 EGE00443.1 - 0.51 9.4 2.2 5.6 6.0 0.1 2.3 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 AAA_11 PF13086.6 EGE00443.1 - 0.53 10.0 0.0 0.53 10.0 0.0 3.1 2 1 0 3 3 2 0 AAA domain CLZ PF16526.5 EGE00443.1 - 1.1 9.7 12.5 0.2 12.1 7.3 2.6 2 0 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels RPN2_C PF18004.1 EGE00443.1 - 8 6.4 10.4 17 5.3 10.4 1.5 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain TauD PF02668.16 EGE00444.1 - 2.9e-35 122.4 0.0 4.1e-35 121.9 0.0 1.2 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family DUF971 PF06155.12 EGE00444.1 - 1.6e-12 47.9 0.0 3.4e-12 46.8 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF971) CsiD PF08943.10 EGE00444.1 - 0.0029 16.8 0.0 0.021 14.0 0.0 1.9 1 1 0 1 1 1 1 CsiD MaoC_dehydratas PF01575.19 EGE00445.1 - 4.9e-23 81.0 0.0 4.2e-22 78.0 0.0 2.1 1 1 0 1 1 1 1 MaoC like domain MaoC_dehydrat_N PF13452.6 EGE00445.1 - 1.1e-09 38.5 0.0 0.00031 20.9 0.0 2.2 2 0 0 2 2 2 2 N-terminal half of MaoC dehydratase Methyltransf_25 PF13649.6 EGE00446.1 - 9.8e-12 45.4 0.0 2.3e-11 44.2 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 EGE00446.1 - 1.2e-10 41.3 0.0 1.8e-10 40.7 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_31 PF13847.6 EGE00446.1 - 2.1e-10 40.6 0.0 3.3e-10 39.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EGE00446.1 - 1.3e-07 32.2 0.0 3.4e-07 30.8 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EGE00446.1 - 1e-06 28.7 0.0 2.4e-06 27.5 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_9 PF08003.11 EGE00446.1 - 4.9e-06 25.7 0.0 6.8e-06 25.2 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) CMAS PF02353.20 EGE00446.1 - 2e-05 24.0 0.0 2.9e-05 23.5 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_18 PF12847.7 EGE00446.1 - 3.6e-05 23.7 0.4 0.00011 22.2 0.1 1.8 1 1 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 EGE00446.1 - 0.00029 20.4 0.0 0.00048 19.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_12 PF08242.12 EGE00446.1 - 0.0004 21.1 0.0 0.00084 20.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.19 EGE00446.1 - 0.0077 16.4 0.0 0.014 15.5 0.0 1.4 1 0 0 1 1 1 1 FtsJ-like methyltransferase Ubie_methyltran PF01209.18 EGE00446.1 - 0.018 14.4 0.0 0.026 13.9 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family PRMT5 PF05185.16 EGE00446.1 - 0.019 14.8 0.1 0.044 13.6 0.1 1.6 1 1 0 1 1 1 0 PRMT5 arginine-N-methyltransferase Methyltransf_32 PF13679.6 EGE00446.1 - 0.02 14.9 0.0 0.036 14.1 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain PCMT PF01135.19 EGE00446.1 - 0.033 13.9 0.2 0.056 13.2 0.2 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Cons_hypoth95 PF03602.15 EGE00446.1 - 0.036 13.7 0.0 0.057 13.1 0.0 1.2 1 0 0 1 1 1 0 Conserved hypothetical protein 95 Methyltransf_16 PF10294.9 EGE00446.1 - 0.045 13.5 0.0 0.066 12.9 0.0 1.2 1 0 0 1 1 1 0 Lysine methyltransferase DUF2007 PF09413.10 EGE00447.1 - 0.017 15.3 0.0 0.032 14.4 0.0 1.4 1 0 0 1 1 1 0 Putative prokaryotic signal transducing protein Per1 PF04080.13 EGE00448.1 - 8.8e-104 346.8 13.6 1e-103 346.5 13.6 1.1 1 0 0 1 1 1 1 Per1-like family NiFe_hyd_3_EhaA PF17367.2 EGE00448.1 - 0.24 11.6 1.7 11 6.2 0.1 2.4 2 0 0 2 2 2 0 NiFe-hydrogenase-type-3 Eha complex subunit A PGM_PMM_I PF02878.16 EGE00449.1 - 2.1e-18 66.4 0.7 5.2e-08 32.7 0.0 3.2 2 1 1 3 3 3 2 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_IV PF00408.20 EGE00449.1 - 2.1e-10 40.6 0.8 6.9e-10 39.0 0.2 2.2 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain PGM_PMM_III PF02880.16 EGE00449.1 - 0.00048 20.3 0.5 0.0024 18.1 0.5 2.1 1 1 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.16 EGE00449.1 - 0.0017 18.9 0.6 0.012 16.2 0.3 2.6 2 1 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II DEAD PF00270.29 EGE00450.1 - 1.6e-47 161.5 0.0 2.5e-47 160.9 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EGE00450.1 - 1.2e-30 106.1 0.0 1.2e-29 102.9 0.0 2.5 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EGE00450.1 - 2.3e-05 24.5 0.0 4.6e-05 23.5 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Brix PF04427.18 EGE00451.1 - 7.9e-49 166.4 0.2 1.1e-48 165.9 0.2 1.2 1 0 0 1 1 1 1 Brix domain PPP4R2 PF09184.11 EGE00451.1 - 1.2 8.7 12.4 2.4 7.7 12.4 1.5 1 0 0 1 1 1 0 PPP4R2 Lum_binding PF00677.17 EGE00452.1 - 6.6e-45 151.0 0.6 1.7e-22 79.2 0.2 2.2 2 0 0 2 2 2 2 Lumazine binding domain Lumazine_bd_2 PF12893.7 EGE00452.1 - 0.0068 17.1 0.1 0.02 15.5 0.0 1.8 1 1 0 1 1 1 1 Putative lumazine-binding YabP PF07873.11 EGE00452.1 - 0.028 14.2 0.0 3.7 7.4 0.0 2.5 2 0 0 2 2 2 0 YabP family CoA_transf_3 PF02515.17 EGE00453.1 - 7.7e-129 430.0 0.0 8.9e-129 429.8 0.0 1.0 1 0 0 1 1 1 1 CoA-transferase family III PHD PF00628.29 EGE00454.1 - 1.9e-07 30.8 9.3 3.6e-07 30.0 9.3 1.5 1 0 0 1 1 1 1 PHD-finger Prok-RING_1 PF14446.6 EGE00454.1 - 0.61 10.1 7.8 1.2 9.1 7.8 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 Band_7 PF01145.25 EGE00455.1 - 5.9e-27 94.8 2.6 1e-26 94.1 2.6 1.3 1 0 0 1 1 1 1 SPFH domain / Band 7 family Dak1_2 PF13684.6 EGE00455.1 - 0.016 14.3 1.0 0.023 13.8 1.0 1.2 1 0 0 1 1 1 0 Dihydroxyacetone kinase family Band_7_1 PF13421.6 EGE00455.1 - 0.03 14.0 0.1 0.049 13.3 0.1 1.3 1 0 0 1 1 1 0 SPFH domain-Band 7 family Ribosomal_L27e PF01777.18 EGE00457.1 - 3.3e-38 129.9 4.0 4.3e-38 129.5 4.0 1.1 1 0 0 1 1 1 1 Ribosomal L27e protein family KOW PF00467.29 EGE00457.1 - 0.0012 18.7 0.2 0.0042 17.0 0.1 2.0 2 0 0 2 2 2 1 KOW motif DUF948 PF06103.11 EGE00458.1 - 1e-06 28.9 47.8 0.22 11.8 0.0 14.3 9 4 8 17 17 17 5 Bacterial protein of unknown function (DUF948) DUF1664 PF07889.12 EGE00458.1 - 0.00096 19.2 51.7 0.17 11.9 0.0 12.4 9 5 5 15 15 15 6 Protein of unknown function (DUF1664) NPV_P10 PF05531.12 EGE00458.1 - 0.018 15.5 35.4 17 5.9 0.0 12.7 9 2 3 12 12 12 0 Nucleopolyhedrovirus P10 protein DIL PF01843.19 EGE00458.1 - 0.12 12.6 0.6 17 5.7 0.1 3.1 2 0 0 2 2 2 0 DIL domain UBA_2 PF08587.11 EGE00458.1 - 1.2 9.3 17.0 68 3.7 0.0 8.4 6 2 2 8 8 8 0 Ubiquitin associated domain (UBA) HALZ PF02183.18 EGE00458.1 - 1.7 8.9 12.1 2.4 8.4 2.7 4.6 5 0 0 5 5 5 0 Homeobox associated leucine zipper SWIB PF02201.18 EGE00459.1 - 7.7e-07 28.9 0.0 1.3e-06 28.1 0.0 1.4 1 0 0 1 1 1 1 SWIB/MDM2 domain PCI PF01399.27 EGE00460.1 - 2.8e-20 72.8 0.1 5.6e-20 71.8 0.1 1.5 1 0 0 1 1 1 1 PCI domain RPN6_C_helix PF18503.1 EGE00460.1 - 8.3e-12 44.6 0.5 2.5e-11 43.1 0.5 1.9 1 0 0 1 1 1 1 26S proteasome subunit RPN6 C-terminal helix domain DDRGK PF09756.9 EGE00460.1 - 0.00013 21.7 0.2 0.00022 20.9 0.2 1.3 1 0 0 1 1 1 1 DDRGK domain TPR_12 PF13424.6 EGE00460.1 - 0.00025 21.3 8.6 0.07 13.4 0.6 3.8 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_MalT PF17874.1 EGE00460.1 - 0.00082 18.8 2.7 0.005 16.3 1.4 2.2 1 1 1 2 2 2 1 MalT-like TPR region TPR_2 PF07719.17 EGE00460.1 - 0.007 16.4 0.8 33 4.9 0.3 3.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.28 EGE00460.1 - 0.017 14.9 0.2 3.1 7.8 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.6 EGE00460.1 - 0.054 13.7 0.3 42 4.7 0.0 3.9 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF3496 PF12001.8 EGE00460.1 - 0.08 13.3 0.4 1.7 9.1 0.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3496) DUF4398 PF14346.6 EGE00460.1 - 0.35 11.5 3.6 0.64 10.7 0.5 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4398) Sof1 PF04158.14 EGE00461.1 - 1.8e-30 105.1 14.7 2.1e-30 104.8 14.7 1.1 1 0 0 1 1 1 1 Sof1-like domain WD40 PF00400.32 EGE00461.1 - 0.00097 19.9 0.1 0.0016 19.2 0.1 1.3 1 0 0 1 1 1 1 WD domain, G-beta repeat adh_short PF00106.25 EGE00462.1 - 6.3e-34 117.1 0.2 1.2e-33 116.2 0.2 1.4 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EGE00462.1 - 1.6e-27 96.6 0.1 3.3e-27 95.6 0.0 1.5 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EGE00462.1 - 2.5e-05 24.3 0.4 7e-05 22.8 0.4 1.7 1 1 0 1 1 1 1 KR domain IF-2 PF11987.8 EGE00462.1 - 0.099 12.8 0.2 0.26 11.4 0.2 1.6 1 0 0 1 1 1 0 Translation-initiation factor 2 DUF2306 PF10067.9 EGE00463.1 - 0.0018 18.5 1.4 0.0021 18.3 0.2 1.7 2 0 0 2 2 2 1 Predicted membrane protein (DUF2306) Fungal_trans_2 PF11951.8 EGE00464.1 - 2.1e-10 40.0 0.2 3.3e-10 39.3 0.2 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EGE00464.1 - 7.7e-08 32.3 9.5 1.8e-07 31.2 9.5 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Glyoxalase PF00903.25 EGE00465.1 - 1.9e-06 28.1 0.0 2.8e-06 27.5 0.0 1.2 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_2 PF12681.7 EGE00465.1 - 0.0053 16.7 0.0 0.0082 16.1 0.0 1.3 1 0 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_6 PF18029.1 EGE00465.1 - 0.066 14.0 0.0 0.11 13.3 0.0 1.5 1 1 0 1 1 1 0 Glyoxalase-like domain PUF PF00806.19 EGE00466.1 - 5.9e-12 44.6 0.0 0.34 10.7 0.0 7.3 8 0 0 8 8 8 5 Pumilio-family RNA binding repeat Pyridoxal_deC PF00282.19 EGE00467.1 - 2e-76 257.2 0.0 2.4e-76 256.9 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.19 EGE00467.1 - 4.1e-08 32.6 0.0 5.9e-08 32.1 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 EGE00467.1 - 1.7e-06 27.5 0.0 1.9e-06 27.4 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase SepSecS PF05889.13 EGE00467.1 - 0.028 13.1 0.0 0.048 12.4 0.0 1.3 1 0 0 1 1 1 0 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS RINT1_TIP1 PF04437.13 EGE00468.1 - 4.4e-181 603.1 0.6 9.5e-181 602.0 0.0 1.8 2 1 0 2 2 2 1 RINT-1 / TIP-1 family SLX9 PF15341.6 EGE00468.1 - 0.013 15.9 3.9 0.032 14.6 3.9 1.7 1 0 0 1 1 1 0 Ribosome biogenesis protein SLX9 Uso1_p115_C PF04871.13 EGE00468.1 - 0.042 14.2 9.6 0.12 12.8 9.6 1.7 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region Nup54 PF13874.6 EGE00468.1 - 0.045 13.9 6.3 0.15 12.1 6.3 1.9 1 0 0 1 1 1 0 Nucleoporin complex subunit 54 CRISPR_Cse2 PF09485.10 EGE00468.1 - 0.24 11.9 2.8 1.1 9.8 2.8 2.2 1 0 0 1 1 1 0 CRISPR-associated protein Cse2 (CRISPR_cse2) ALMT PF11744.8 EGE00468.1 - 4 6.2 7.3 6.1 5.5 7.3 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter DNA_ligase_A_M PF01068.21 EGE00469.1 - 1.3e-50 171.9 0.0 6.2e-48 163.2 0.0 2.3 2 0 0 2 2 2 2 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 EGE00469.1 - 5.9e-37 127.6 0.0 1e-36 126.8 0.0 1.4 1 0 0 1 1 1 1 DNA ligase N terminus DNA_ligase_A_C PF04679.15 EGE00469.1 - 1.3e-19 70.6 0.0 4.7e-19 68.8 0.0 2.0 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region RNA_ligase PF09414.10 EGE00469.1 - 0.025 14.9 0.0 0.049 13.9 0.0 1.5 1 0 0 1 1 1 0 RNA ligase Peptidase_C36 PF05415.11 EGE00469.1 - 0.15 12.3 0.0 0.41 10.9 0.0 1.7 1 0 0 1 1 1 0 Beet necrotic yellow vein furovirus-type papain-like endopeptidase DJ-1_PfpI PF01965.24 EGE00470.1 - 3e-11 43.4 0.0 8.8e-11 41.9 0.0 1.8 1 1 0 1 1 1 1 DJ-1/PfpI family ThiJ_like PF17124.5 EGE00470.1 - 0.05 13.3 0.5 0.23 11.1 0.5 2.0 1 1 0 1 1 1 0 ThiJ/PfpI family-like GST_N_3 PF13417.6 EGE00471.1 - 4e-08 33.6 0.1 7.8e-08 32.6 0.1 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EGE00471.1 - 2.7e-07 30.5 0.3 9e-07 28.8 0.2 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 EGE00471.1 - 2.5e-06 27.7 0.0 5.9e-06 26.5 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EGE00471.1 - 0.0019 18.4 0.0 0.0042 17.3 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EGE00471.1 - 0.0032 17.6 0.0 0.0067 16.6 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EGE00471.1 - 0.0034 17.7 0.0 0.0068 16.7 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Metallopep PF12044.8 EGE00473.1 - 1.7e-122 409.1 0.0 3.8e-62 210.3 0.3 2.1 1 1 1 2 2 2 2 Putative peptidase family FlgT_M PF16539.5 EGE00473.1 - 0.12 12.5 0.1 0.23 11.6 0.1 1.3 1 0 0 1 1 1 0 Flagellar assembly protein T, middle domain Cwf_Cwc_15 PF04889.12 EGE00477.1 - 0.0049 16.6 3.2 0.0054 16.5 3.2 1.2 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein NOA36 PF06524.12 EGE00477.1 - 0.027 13.8 4.6 0.03 13.7 4.6 1.1 1 0 0 1 1 1 0 NOA36 protein RXT2_N PF08595.11 EGE00477.1 - 0.052 13.6 0.7 0.065 13.3 0.7 1.1 1 0 0 1 1 1 0 RXT2-like, N-terminal FAM176 PF14851.6 EGE00477.1 - 0.47 10.1 2.1 0.78 9.4 2.1 1.4 1 0 0 1 1 1 0 FAM176 family PBP1_TM PF14812.6 EGE00477.1 - 3.3 8.1 10.5 1.2 9.5 7.9 1.7 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal CENP-B_dimeris PF09026.10 EGE00477.1 - 7.4 7.0 17.3 12 6.4 17.3 1.2 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Auts2 PF15336.6 EGE00478.1 - 0.023 14.8 2.5 0.08 13.0 2.5 1.8 1 1 0 1 1 1 0 Autism susceptibility gene 2 protein Sod_Cu PF00080.20 EGE00478.1 - 0.13 12.5 0.0 0.17 12.1 0.0 1.2 1 0 0 1 1 1 0 Copper/zinc superoxide dismutase (SODC) CDP-OH_P_transf PF01066.21 EGE00479.1 - 2.2e-15 57.2 0.8 2.2e-15 57.2 0.8 2.1 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase MBOAT PF03062.19 EGE00480.1 - 2.5e-54 185.0 3.3 4.7e-54 184.0 3.3 1.4 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family 5_nucleotid PF05761.14 EGE00481.1 - 0.26 10.1 0.1 0.37 9.6 0.1 1.1 1 0 0 1 1 1 0 5' nucleotidase family CPBP PF02517.16 EGE00482.1 - 3.5e-14 52.9 10.2 3.5e-14 52.9 10.2 2.3 2 1 0 2 2 2 1 CPBP intramembrane metalloprotease Suc_Fer-like PF06999.12 EGE00483.1 - 9e-58 195.4 0.0 1e-57 195.2 0.0 1.0 1 0 0 1 1 1 1 Sucrase/ferredoxin-like HofP PF10748.9 EGE00483.1 - 0.00087 18.9 0.0 0.0013 18.3 0.0 1.2 1 0 0 1 1 1 1 DNA utilization proteins HofP zf-C2H2_2 PF12756.7 EGE00484.1 - 2.3e-19 69.6 7.4 1.6e-18 66.9 5.2 2.2 2 0 0 2 2 2 1 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.6 EGE00484.1 - 0.0038 17.9 5.2 13 6.9 0.5 4.0 3 0 0 3 3 3 2 C2H2-type zinc finger zf-met PF12874.7 EGE00484.1 - 0.0079 16.6 0.0 0.029 14.8 0.0 2.1 1 0 0 1 1 1 1 Zinc-finger of C2H2 type Fer4 PF00037.27 EGE00484.1 - 0.48 10.3 0.1 0.48 10.3 0.1 2.5 3 0 0 3 3 3 0 4Fe-4S binding domain tRNA-synt_1 PF00133.22 EGE00485.1 - 3.5e-48 164.3 0.0 1.2e-34 119.5 0.0 5.0 1 1 1 2 2 2 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1_2 PF13603.6 EGE00485.1 - 3.9e-38 130.8 0.0 6e-38 130.2 0.0 1.3 1 0 0 1 1 1 1 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1g PF09334.11 EGE00485.1 - 3.8e-28 98.3 0.8 3.5e-24 85.3 0.0 3.5 3 1 1 4 4 4 2 tRNA synthetases class I (M) Anticodon_1 PF08264.13 EGE00485.1 - 2e-14 53.8 0.0 3.9e-14 52.9 0.0 1.4 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1e PF01406.19 EGE00485.1 - 0.00013 21.4 0.0 0.00039 19.9 0.0 1.7 2 0 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain zf-ribbon_3 PF13248.6 EGE00485.1 - 0.13 11.7 2.7 4.1 6.9 0.2 2.4 2 0 0 2 2 2 0 zinc-ribbon domain Cation_ATPase_C PF00689.21 EGE00486.1 - 0.033 13.9 6.1 0.056 13.1 6.1 1.4 1 0 0 1 1 1 0 Cation transporting ATPase, C-terminus Polysacc_synt_C PF14667.6 EGE00486.1 - 0.72 9.9 12.2 0.46 10.5 8.5 2.4 2 1 0 2 2 2 0 Polysaccharide biosynthesis C-terminal domain PetL PF05115.14 EGE00486.1 - 5.6 7.0 7.1 17 5.5 0.1 2.9 2 0 0 2 2 2 0 Cytochrome B6-F complex subunit VI (PetL) DUF2754 PF10953.8 EGE00486.1 - 6.3 7.1 7.2 3.6 7.9 0.7 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF2754) 2-Hacid_dh_C PF02826.19 EGE00487.1 - 4.7e-49 166.2 0.0 7.2e-49 165.6 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EGE00487.1 - 2.6e-16 59.5 0.0 3.8e-16 59.0 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain Peptidase_S78_2 PF14550.6 EGE00487.1 - 0.11 12.5 0.2 1 9.5 0.0 2.4 3 0 0 3 3 3 0 Putative phage serine protease XkdF FH2 PF02181.23 EGE00489.1 - 6.3e-84 282.2 5.8 6.3e-84 282.2 5.8 2.3 3 0 0 3 3 3 1 Formin Homology 2 Domain Drf_GBD PF06371.13 EGE00489.1 - 6.3e-69 231.3 0.5 2.1e-68 229.6 0.0 2.2 2 0 0 2 2 2 1 Diaphanous GTPase-binding Domain Drf_FH3 PF06367.16 EGE00489.1 - 6.8e-49 166.1 2.3 2.7e-47 160.9 0.7 2.6 1 1 1 2 2 2 2 Diaphanous FH3 Domain Aspzincin_M35 PF14521.6 EGE00490.1 - 0.019 15.5 0.0 0.024 15.2 0.0 1.1 1 0 0 1 1 1 0 Lysine-specific metallo-endopeptidase DUF3886 PF13025.6 EGE00491.1 - 0.064 13.4 0.0 0.064 13.4 0.0 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF3886) TrmE_N PF10396.9 EGE00492.1 - 5.7e-36 123.3 0.0 1.2e-35 122.2 0.0 1.6 1 0 0 1 1 1 1 GTP-binding protein TrmE N-terminus MnmE_helical PF12631.7 EGE00492.1 - 5.4e-29 101.8 0.0 1.8e-28 100.1 0.0 1.7 1 1 0 1 1 1 1 MnmE helical domain MMR_HSR1 PF01926.23 EGE00492.1 - 6.3e-18 64.9 0.0 1.1e-17 64.1 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 EGE00492.1 - 9.6e-06 25.7 0.1 1.8e-05 24.9 0.1 1.5 1 0 0 1 1 1 1 Dynamin family FeoB_N PF02421.18 EGE00492.1 - 2.4e-05 23.9 0.3 0.00017 21.2 0.3 2.1 1 1 0 1 1 1 1 Ferrous iron transport protein B GTP_EFTU PF00009.27 EGE00492.1 - 0.00092 18.8 0.0 0.069 12.7 0.0 2.3 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain Glyco_hydro_3_C PF01915.22 EGE00492.1 - 0.0064 16.5 0.0 0.0099 15.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain AAA_24 PF13479.6 EGE00492.1 - 0.018 14.8 0.0 0.034 13.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 EGE00492.1 - 0.029 14.3 0.3 0.89 9.4 0.1 2.3 2 0 0 2 2 2 0 RsgA GTPase ABC_tran PF00005.27 EGE00492.1 - 0.052 14.1 0.1 0.16 12.4 0.1 1.8 1 1 0 1 1 1 0 ABC transporter MCM PF00493.23 EGE00492.1 - 0.077 12.1 0.0 0.13 11.3 0.0 1.3 1 0 0 1 1 1 0 MCM P-loop domain Roc PF08477.13 EGE00492.1 - 0.13 12.5 0.0 0.48 10.7 0.0 1.9 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase RNA_pol_L_2 PF13656.6 EGE00493.1 - 7.7e-34 115.3 0.0 1e-33 114.9 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.24 EGE00493.1 - 1.7e-14 53.0 0.0 2.5e-14 52.4 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Complex1_LYR_2 PF13233.6 EGE00494.1 - 8.6e-07 29.6 0.4 1.4e-06 29.0 0.4 1.3 1 0 0 1 1 1 1 Complex1_LYR-like Complex1_LYR PF05347.15 EGE00494.1 - 4.3e-06 26.7 0.6 8.7e-06 25.7 0.6 1.6 1 1 0 1 1 1 1 Complex 1 protein (LYR family) DUF5301 PF17225.3 EGE00495.1 - 0.016 15.6 1.0 0.039 14.4 0.1 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF5300) Abhydrolase_1 PF00561.20 EGE00496.1 - 7.7e-14 51.9 0.1 3.3e-13 49.9 0.1 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EGE00496.1 - 6.6e-11 41.9 0.0 2.7e-10 39.9 0.0 1.9 1 1 0 1 1 1 1 Serine aminopeptidase, S33 DUF1749 PF08538.10 EGE00496.1 - 0.013 14.6 0.0 0.02 14.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1749) TRAPPC9-Trs120 PF08626.11 EGE00497.1 - 0 1423.0 0.0 0 1422.8 0.0 1.0 1 0 0 1 1 1 1 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit DUF3684 PF12449.8 EGE00498.1 - 0 1418.4 0.0 0 1417.9 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3684) HATPase_c_3 PF13589.6 EGE00498.1 - 0.00015 21.6 0.0 0.00042 20.1 0.0 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF1117 PF06547.12 EGE00498.1 - 0.2 12.2 0.3 0.95 10.0 0.3 2.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1117) UPF0767 PF15990.5 EGE00498.1 - 0.76 10.0 2.3 2.5 8.3 2.3 1.8 1 0 0 1 1 1 0 UPF0767 family Roughex PF06020.11 EGE00498.1 - 0.86 8.6 3.8 15 4.6 2.0 2.2 2 0 0 2 2 2 0 Drosophila roughex protein WLM PF08325.10 EGE00498.1 - 4.9 7.2 7.9 0.29 11.2 0.7 2.4 3 0 0 3 3 3 0 WLM domain Pro-kuma_activ PF09286.11 EGE00499.1 - 1.3e-37 129.2 0.2 2.3e-37 128.5 0.2 1.4 1 0 0 1 1 1 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.22 EGE00499.1 - 0.00049 19.4 0.3 0.0023 17.3 0.0 2.1 2 1 0 2 2 2 1 Subtilase family MATH PF00917.26 EGE00499.1 - 0.11 12.7 0.0 0.25 11.5 0.0 1.5 1 0 0 1 1 1 0 MATH domain BTB PF00651.31 EGE00501.1 - 0.027 14.7 0.0 0.053 13.7 0.0 1.4 1 0 0 1 1 1 0 BTB/POZ domain RdRP PF05183.12 EGE00502.1 - 1.6e-180 601.6 0.0 2.1e-180 601.3 0.0 1.1 1 0 0 1 1 1 1 RNA dependent RNA polymerase Lsm_C PF14894.6 EGE00502.1 - 0.13 12.0 0.0 0.62 9.9 0.0 2.2 1 0 0 1 1 1 0 Lsm C-terminal Med6 PF04934.14 EGE00503.1 - 7.4e-40 135.8 0.0 1.7e-39 134.7 0.1 1.5 2 0 0 2 2 2 1 MED6 mediator sub complex component Lysine_decarbox PF03641.14 EGE00504.1 - 4.4e-20 72.1 0.2 7.2e-20 71.4 0.2 1.4 1 0 0 1 1 1 1 Possible lysine decarboxylase LDcluster4 PF18306.1 EGE00504.1 - 0.0088 15.6 0.5 0.018 14.6 0.1 1.7 2 0 0 2 2 2 1 SLOG cluster4 family Proteasome PF00227.26 EGE00505.1 - 2.7e-48 164.0 0.3 4e-48 163.4 0.3 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EGE00505.1 - 2.9e-12 46.0 1.1 5e-12 45.3 0.3 1.8 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature GYD PF08734.11 EGE00505.1 - 0.068 13.1 0.0 0.16 11.9 0.0 1.6 1 0 0 1 1 1 0 GYD domain Vps55 PF04133.14 EGE00506.1 - 2.6e-45 153.2 8.9 2.9e-45 153.0 8.9 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting 55 DUF4231 PF14015.6 EGE00506.1 - 0.59 10.6 0.0 0.59 10.6 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4231) Sld7_C PF18596.1 EGE00507.1 - 2.8e-10 40.2 0.0 1.7e-09 37.7 0.0 2.2 1 1 0 1 1 1 1 Sld7 C-terminal domain UPF0220 PF05255.11 EGE00508.1 - 2.9e-69 231.9 4.1 3.3e-69 231.7 4.1 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0220) G3P_antiterm PF04309.12 EGE00508.1 - 0.13 11.6 0.0 0.23 10.9 0.0 1.3 1 0 0 1 1 1 0 Glycerol-3-phosphate responsive antiterminator DUF5337 PF17272.2 EGE00508.1 - 1.5 8.7 4.7 5.3 6.9 0.3 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5337) HEAT_EZ PF13513.6 EGE00509.1 - 1.1e-06 29.0 0.0 1.8e-06 28.3 0.0 1.4 1 0 0 1 1 1 1 HEAT-like repeat HEAT_2 PF13646.6 EGE00509.1 - 0.0014 19.0 0.1 0.0018 18.6 0.1 1.3 1 0 0 1 1 1 1 HEAT repeats HEAT PF02985.22 EGE00509.1 - 0.013 15.7 0.0 0.027 14.7 0.0 1.6 1 0 0 1 1 1 0 HEAT repeat Arm PF00514.23 EGE00509.1 - 0.014 15.4 0.0 0.03 14.4 0.0 1.6 1 0 0 1 1 1 0 Armadillo/beta-catenin-like repeat SIL1 PF16782.5 EGE00509.1 - 0.022 14.0 0.0 0.022 14.0 0.0 1.2 1 0 0 1 1 1 0 Nucleotide exchange factor SIL1 RICTOR_V PF14668.6 EGE00509.1 - 0.051 13.8 0.0 0.067 13.4 0.0 1.2 1 0 0 1 1 1 0 Rapamycin-insensitive companion of mTOR, domain 5 ANAPC5 PF12862.7 EGE00509.1 - 0.058 13.5 0.1 4.4 7.4 0.0 2.2 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 5 Cytochrom_B562 PF07361.11 EGE00509.1 - 0.068 13.8 0.2 0.084 13.5 0.2 1.2 1 0 0 1 1 1 0 Cytochrome b562 Actin PF00022.19 EGE00510.1 - 1.5e-105 353.2 0.0 7.5e-105 350.9 0.0 1.7 1 1 0 1 1 1 1 Actin Glyco_hydro_18 PF00704.28 EGE00511.1 - 6.1e-60 203.6 7.1 3.7e-44 151.7 0.9 2.0 1 1 1 2 2 2 2 Glycosyl hydrolases family 18 AIRS_C PF02769.22 EGE00512.1 - 1.5e-35 122.7 0.3 4.2e-35 121.2 0.0 1.8 2 0 0 2 2 2 1 AIR synthase related protein, C-terminal domain GARS_C PF02843.16 EGE00512.1 - 3.1e-27 94.6 0.7 7.1e-27 93.5 0.7 1.6 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, C domain GARS_A PF01071.19 EGE00512.1 - 4.3e-21 75.6 0.0 8e-21 74.7 0.0 1.5 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain AIRS PF00586.24 EGE00512.1 - 1.3e-14 54.6 1.5 4.3e-14 52.9 1.5 1.9 1 0 0 1 1 1 1 AIR synthase related protein, N-terminal domain PCI PF01399.27 EGE00513.1 - 8.7e-23 80.8 0.0 3.2e-22 79.0 0.0 2.0 1 0 0 1 1 1 1 PCI domain RPN5_C PF18098.1 EGE00513.1 - 2e-16 59.8 1.9 5.3e-16 58.4 1.9 1.8 1 0 0 1 1 1 1 26S proteasome regulatory subunit RPN5 C-terminal domain CLTH PF10607.9 EGE00513.1 - 0.03 14.2 1.7 3 7.7 1.7 2.8 1 1 0 1 1 1 0 CTLH/CRA C-terminal to LisH motif domain FSH1 PF03959.13 EGE00514.1 - 1.3e-66 224.3 0.0 1.8e-66 223.8 0.0 1.1 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_6 PF12697.7 EGE00514.1 - 0.00064 20.4 0.8 0.0018 19.0 0.8 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family DLH PF01738.18 EGE00514.1 - 0.0095 15.5 0.0 0.16 11.5 0.0 2.2 2 0 0 2 2 2 1 Dienelactone hydrolase family BAAT_C PF08840.11 EGE00514.1 - 0.061 13.2 0.0 0.1 12.5 0.0 1.3 1 0 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal Abhydrolase_2 PF02230.16 EGE00514.1 - 0.08 12.7 0.1 11 5.7 0.1 2.8 3 0 0 3 3 3 0 Phospholipase/Carboxylesterase Hydrolase_4 PF12146.8 EGE00514.1 - 0.094 12.0 0.1 0.3 10.3 0.0 1.8 3 0 0 3 3 3 0 Serine aminopeptidase, S33 Esterase_phd PF10503.9 EGE00514.1 - 0.2 11.1 0.0 2.1 7.8 0.0 2.1 2 0 0 2 2 2 0 Esterase PHB depolymerase Acyltransferase PF01553.21 EGE00515.1 - 0.048 13.3 0.0 0.092 12.4 0.0 1.4 1 1 0 1 1 1 0 Acyltransferase Ribosomal_S27e PF01667.17 EGE00518.1 - 1e-28 98.8 6.7 1.3e-28 98.5 6.7 1.1 1 0 0 1 1 1 1 Ribosomal protein S27 zf-C2HC5 PF06221.13 EGE00518.1 - 0.26 11.3 6.1 2 8.4 4.2 2.3 2 1 0 2 2 2 0 Putative zinc finger motif, C2HC5-type CDP-OH_P_transf PF01066.21 EGE00520.1 - 1.8e-17 63.8 0.0 1.8e-17 63.8 0.0 3.3 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase NIPSNAP PF07978.13 EGE00521.1 - 2e-41 140.3 0.4 1.3e-29 102.4 0.1 2.4 2 0 0 2 2 2 2 NIPSNAP MSA-2c PF12238.8 EGE00521.1 - 0.22 11.5 8.3 0.38 10.7 8.3 1.3 1 0 0 1 1 1 0 Merozoite surface antigen 2c SASRP1 PF15160.6 EGE00521.1 - 0.25 11.0 1.9 0.43 10.2 1.9 1.3 1 0 0 1 1 1 0 Spermatogenesis-associated serine-rich protein 1 QWRF PF04484.12 EGE00521.1 - 8.2 6.1 8.6 57 3.3 10.0 1.6 2 0 0 2 2 2 0 QWRF family Putative_PNPOx PF01243.20 EGE00522.1 - 3.6e-12 46.3 0.0 7.3e-12 45.3 0.0 1.5 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Pyridox_ox_2 PF12900.7 EGE00522.1 - 0.062 13.3 0.0 0.19 11.7 0.0 1.8 2 0 0 2 2 2 0 Pyridoxamine 5'-phosphate oxidase Peptidase_C65 PF10275.9 EGE00523.1 - 1.9e-34 119.3 0.3 2.9e-34 118.6 0.3 1.3 1 0 0 1 1 1 1 Peptidase C65 Otubain PCI PF01399.27 EGE00525.1 - 3e-16 59.8 1.3 4.7e-16 59.2 0.1 1.9 2 1 0 2 2 2 1 PCI domain TPR_7 PF13176.6 EGE00525.1 - 0.0026 17.6 0.1 0.11 12.6 0.1 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 EGE00525.1 - 0.0078 15.9 0.3 0.082 12.6 0.1 2.8 2 0 0 2 2 2 1 TPR repeat TPR_2 PF07719.17 EGE00525.1 - 0.02 15.0 5.3 0.094 12.9 0.1 4.4 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_12 PF13424.6 EGE00525.1 - 0.024 14.9 0.4 0.68 10.3 0.0 3.1 3 1 0 3 3 3 0 Tetratricopeptide repeat CorA PF01544.18 EGE00525.1 - 0.025 13.9 0.4 0.056 12.8 0.4 1.5 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein TPR_14 PF13428.6 EGE00525.1 - 0.028 15.2 0.2 1.3 10.0 0.0 3.2 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.28 EGE00525.1 - 0.11 12.3 3.5 0.35 10.8 0.1 3.5 5 0 0 5 5 5 0 Tetratricopeptide repeat CWC25 PF12542.8 EGE00526.1 - 1e-25 90.6 0.5 1e-25 90.6 0.5 4.1 3 2 1 4 4 4 2 Pre-mRNA splicing factor Cir_N PF10197.9 EGE00526.1 - 8.7e-14 51.4 10.4 8.7e-14 51.4 10.4 4.6 4 2 2 6 6 6 1 N-terminal domain of CBF1 interacting co-repressor CIR Ras PF00071.22 EGE00527.1 - 7.1e-53 178.5 0.0 8.3e-53 178.3 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EGE00527.1 - 8.6e-22 77.6 0.0 1.3e-21 77.0 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EGE00527.1 - 8.7e-11 41.6 0.0 1.3e-10 41.1 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EGE00527.1 - 6.8e-05 22.3 0.0 8.7e-05 22.0 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 EGE00527.1 - 0.0013 18.2 0.0 0.0018 17.7 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 EGE00527.1 - 0.0024 17.1 0.0 0.0041 16.3 0.0 1.4 1 1 0 1 1 1 1 G-protein alpha subunit MMR_HSR1 PF01926.23 EGE00527.1 - 0.0076 16.3 0.0 0.012 15.7 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EGE00527.1 - 0.021 14.7 0.0 6.3 6.7 0.0 2.2 2 0 0 2 2 2 0 RsgA GTPase AAA_16 PF13191.6 EGE00527.1 - 0.14 12.6 0.0 0.17 12.3 0.0 1.6 1 1 0 1 1 1 0 AAA ATPase domain ABC_tran PF00005.27 EGE00527.1 - 0.14 12.7 0.0 0.27 11.7 0.0 1.6 1 1 0 1 1 1 0 ABC transporter BPL_LplA_LipB PF03099.19 EGE00528.1 - 3.7e-06 26.9 0.0 6.3e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family F-box PF00646.33 EGE00529.1 - 0.011 15.6 3.3 0.33 10.9 0.2 3.4 3 0 0 3 3 3 0 F-box domain DUF3387 PF11867.8 EGE00529.1 - 0.28 10.5 0.0 0.44 9.9 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3387) Ank_2 PF12796.7 EGE00530.1 - 2.1e-14 53.9 0.1 5.1e-07 30.2 0.1 2.2 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EGE00530.1 - 1.2e-11 44.9 0.5 2.2e-05 24.9 0.0 3.1 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 EGE00530.1 - 1.8e-11 44.0 2.5 0.0011 19.3 0.1 3.7 3 1 0 3 3 3 3 Ankyrin repeat Ank_5 PF13857.6 EGE00530.1 - 4.3e-09 36.5 2.1 0.0074 16.6 0.2 3.3 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EGE00530.1 - 7.4e-08 32.1 0.1 0.075 13.6 0.0 3.9 4 0 0 4 4 4 2 Ankyrin repeat polyprenyl_synt PF00348.17 EGE00531.1 - 2.7e-67 226.5 0.0 3.4e-66 222.9 0.0 2.0 1 1 0 1 1 1 1 Polyprenyl synthetase DUF3659 PF12396.8 EGE00531.1 - 0.063 13.2 0.0 0.74 9.8 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3659) Rpn3_C PF08375.11 EGE00532.1 - 9.9e-26 90.0 0.6 9.9e-26 90.0 0.6 2.3 2 0 0 2 2 2 1 Proteasome regulatory subunit C-terminal PCI PF01399.27 EGE00532.1 - 1.4e-21 77.0 0.1 6.3e-21 74.9 0.0 2.1 2 0 0 2 2 2 1 PCI domain DASH_Spc34 PF08657.10 EGE00533.1 - 1e-43 150.0 6.9 3.6e-21 76.1 4.0 2.1 1 1 1 2 2 2 2 DASH complex subunit Spc34 DUF848 PF05852.11 EGE00533.1 - 0.0041 17.2 4.6 0.0083 16.2 4.6 1.5 1 0 0 1 1 1 1 Gammaherpesvirus protein of unknown function (DUF848) DASH_Spc19 PF08287.11 EGE00533.1 - 0.0077 16.1 3.6 0.017 15.1 3.6 1.5 1 0 0 1 1 1 1 Spc19 Rtt102p PF09510.10 EGE00533.1 - 0.13 12.4 0.6 0.26 11.5 0.6 1.4 1 0 0 1 1 1 0 Rtt102p-like transcription regulator protein Prefoldin_2 PF01920.20 EGE00533.1 - 0.14 12.2 6.6 1.9 8.5 0.8 2.5 2 0 0 2 2 2 0 Prefoldin subunit VSG_B PF13206.6 EGE00533.1 - 0.15 11.3 0.2 0.23 10.7 0.2 1.3 1 0 0 1 1 1 0 Trypanosomal VSG domain ATG16 PF08614.11 EGE00533.1 - 8 6.6 13.4 46 4.1 1.6 2.8 2 1 1 3 3 3 0 Autophagy protein 16 (ATG16) F-box PF00646.33 EGE00534.1 - 0.00012 21.8 0.0 0.00024 20.9 0.0 1.4 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EGE00534.1 - 0.01 15.7 0.0 0.028 14.3 0.0 1.7 1 0 0 1 1 1 0 F-box-like TFIID_20kDa PF03847.13 EGE00535.1 - 1.3e-23 83.3 0.0 2.2e-23 82.5 0.0 1.4 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A CorA PF01544.18 EGE00536.1 - 8.4e-15 54.9 1.0 1.5e-14 54.0 1.0 1.3 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein DUF1203 PF06718.11 EGE00537.1 - 2.9e-36 124.3 0.0 3.6e-36 124.0 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1203) PilM PF07419.12 EGE00537.1 - 0.11 12.7 0.0 0.15 12.3 0.0 1.1 1 0 0 1 1 1 0 PilM eIF2A PF08662.11 EGE00539.1 - 3.1e-84 281.7 0.1 1e-82 276.8 0.0 2.2 2 0 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A WD40 PF00400.32 EGE00539.1 - 0.016 16.0 0.8 2.1 9.3 0.1 3.9 3 1 1 4 4 4 0 WD domain, G-beta repeat NAD_binding_6 PF08030.12 EGE00540.1 - 8.7e-34 116.9 0.0 1.4e-33 116.2 0.0 1.3 1 0 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 EGE00540.1 - 5.7e-23 81.1 0.0 2.5e-22 79.0 0.0 2.1 2 0 0 2 2 2 1 FAD-binding domain Ferric_reduct PF01794.19 EGE00540.1 - 2.4e-18 66.4 8.1 2.4e-18 66.4 8.1 2.4 1 1 0 2 2 2 1 Ferric reductase like transmembrane component FAD_binding_6 PF00970.24 EGE00540.1 - 0.041 14.2 0.0 0.089 13.2 0.0 1.5 1 0 0 1 1 1 0 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.21 EGE00540.1 - 0.087 13.5 0.0 0.29 11.8 0.0 2.0 1 1 0 1 1 1 0 Oxidoreductase NAD-binding domain baeRF_family10 PF18854.1 EGE00541.1 - 0.1 12.8 1.7 0.22 11.8 1.7 1.5 1 0 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 10 Acetyltransf_13 PF13880.6 EGE00542.1 - 5.4e-28 96.8 0.0 1.3e-27 95.5 0.0 1.7 1 0 0 1 1 1 1 ESCO1/2 acetyl-transferase zf-C2H2_3 PF13878.6 EGE00542.1 - 8.2e-13 47.9 0.5 1.5e-12 47.1 0.5 1.5 1 0 0 1 1 1 1 zinc-finger of acetyl-transferase ESCO FSA_C PF10479.9 EGE00542.1 - 0.28 9.3 9.3 0.032 12.4 4.8 1.6 2 0 0 2 2 2 0 Fragile site-associated protein C-terminus Dicty_REP PF05086.12 EGE00542.1 - 2.3 6.1 3.2 2.9 5.7 3.2 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein SSP160 PF06933.11 EGE00542.1 - 3.3 5.8 19.7 0.4 8.8 14.6 1.8 2 0 0 2 2 2 0 Special lobe-specific silk protein SSP160 Acyl-CoA_dh_N PF02771.16 EGE00544.1 - 2.2e-26 92.8 0.1 5.7e-26 91.4 0.1 1.8 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_1 PF00441.24 EGE00544.1 - 3.7e-25 88.9 0.3 5.8e-25 88.2 0.3 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 EGE00544.1 - 2.1e-15 56.7 0.0 4.2e-15 55.7 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 EGE00544.1 - 3.8e-07 30.4 0.5 3.8e-07 30.4 0.5 1.7 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Pet127 PF08634.10 EGE00545.1 - 2.3e-118 394.6 0.0 3.2e-118 394.1 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial protein Pet127 LRR_6 PF13516.6 EGE00547.1 - 0.42 10.8 6.8 23 5.4 0.1 4.9 4 0 0 4 4 4 0 Leucine Rich repeat SelP_N PF04592.14 EGE00547.1 - 3.5 7.0 19.6 0.59 9.5 3.3 2.5 2 0 0 2 2 2 0 Selenoprotein P, N terminal region LHC PF00556.20 EGE00548.1 - 0.17 12.1 0.4 0.33 11.2 0.4 1.4 1 0 0 1 1 1 0 Antenna complex alpha/beta subunit Mito_fiss_reg PF05308.11 EGE00548.1 - 2.5 8.1 6.4 0.65 10.0 2.8 1.8 2 0 0 2 2 2 0 Mitochondrial fission regulator Gly_transf_sug PF04488.15 EGE00549.1 - 5.2e-19 68.7 0.0 9.3e-19 67.9 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif MMR1 PF08505.10 EGE00550.1 - 0.062 13.6 3.6 0.079 13.2 3.6 1.0 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Abhydrolase_6 PF12697.7 EGE00551.1 - 2.7e-15 57.6 1.1 3.5e-15 57.2 1.1 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EGE00551.1 - 6.8e-09 35.7 0.0 6e-08 32.6 0.0 2.4 1 1 0 1 1 1 1 alpha/beta hydrolase fold DUF3089 PF11288.8 EGE00551.1 - 0.085 12.4 0.1 0.55 9.7 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3089) Bul1_N PF04425.12 EGE00552.1 - 3.1e-05 22.9 0.4 7.1e-05 21.7 0.3 1.5 1 1 0 1 1 1 1 Bul1 N terminus Arrestin_N PF00339.29 EGE00552.1 - 0.00075 19.6 0.0 0.0022 18.0 0.0 1.8 1 1 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain Bul1_C PF04426.12 EGE00552.1 - 0.005 16.3 0.0 0.012 15.1 0.0 1.5 2 0 0 2 2 2 1 Bul1 C terminus Abhydrolase_3 PF07859.13 EGE00553.1 - 3.9e-05 23.6 0.0 6.8e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_1 PF00561.20 EGE00553.1 - 0.00011 21.9 0.0 0.012 15.3 0.0 2.3 1 1 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EGE00553.1 - 0.00016 21.1 0.0 0.0012 18.2 0.0 1.9 1 1 1 2 2 2 1 Serine aminopeptidase, S33 Peptidase_S15 PF02129.18 EGE00553.1 - 0.00029 20.5 0.0 0.0004 20.1 0.0 1.3 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_6 PF12697.7 EGE00553.1 - 0.0022 18.6 2.9 0.0045 17.6 3.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family LIP PF03583.14 EGE00553.1 - 0.051 12.9 0.1 8.2 5.6 0.0 2.2 2 0 0 2 2 2 0 Secretory lipase Peptidase_S9 PF00326.21 EGE00553.1 - 0.089 12.3 0.0 0.3 10.5 0.0 1.9 1 1 0 1 1 1 0 Prolyl oligopeptidase family Lipase_3 PF01764.25 EGE00553.1 - 0.19 11.6 0.0 0.3 10.9 0.0 1.2 1 0 0 1 1 1 0 Lipase (class 3) AA_permease PF00324.21 EGE00554.1 - 1.1e-137 459.5 44.2 1.4e-137 459.2 44.2 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EGE00554.1 - 7.4e-38 130.5 47.8 9.3e-38 130.2 47.8 1.1 1 0 0 1 1 1 1 Amino acid permease OppC_N PF12911.7 EGE00554.1 - 1.7 8.7 0.0 1.7 8.7 0.0 4.4 5 0 0 5 5 5 0 N-terminal TM domain of oligopeptide transport permease C MFS_1 PF07690.16 EGE00555.1 - 1.5e-24 86.6 39.6 2.4e-24 85.9 39.6 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily p450 PF00067.22 EGE00557.1 - 2.8e-55 187.9 0.0 3.6e-55 187.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Thioesterase PF00975.20 EGE00558.1 - 9.1e-16 58.7 0.0 1.5e-15 58.0 0.0 1.4 1 1 0 1 1 1 1 Thioesterase domain Abhydrolase_6 PF12697.7 EGE00558.1 - 3.5e-07 31.1 0.0 4e-07 30.9 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EGE00558.1 - 0.058 13.0 0.1 0.091 12.4 0.1 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold Cytokin_check_N PF10407.9 EGE00559.1 - 0.00034 20.5 0.0 0.00063 19.6 0.0 1.4 1 0 0 1 1 1 1 Cdc14 phosphatase binding protein N-terminus Pkinase PF00069.25 EGE00560.1 - 1.5e-42 145.8 0.0 2.4e-40 138.6 0.0 2.4 2 1 0 2 2 2 1 Protein kinase domain Ribonuc_2-5A PF06479.12 EGE00560.1 - 6.1e-40 136.3 0.1 1.5e-39 135.1 0.0 1.7 2 0 0 2 2 2 1 Ribonuclease 2-5A Pkinase_Tyr PF07714.17 EGE00560.1 - 5.7e-21 75.0 0.0 6.8e-20 71.4 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase PQQ PF01011.21 EGE00560.1 - 0.00011 21.9 0.1 0.12 12.4 0.0 3.5 3 0 0 3 3 3 1 PQQ enzyme repeat Kdo PF06293.14 EGE00560.1 - 0.00071 19.0 0.0 0.0013 18.1 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EGE00560.1 - 0.001 17.9 0.0 0.0023 16.8 0.0 1.5 1 0 0 1 1 1 1 Fungal protein kinase PQQ_2 PF13360.6 EGE00560.1 - 0.0056 16.3 0.1 0.028 14.0 0.1 2.0 1 1 0 1 1 1 1 PQQ-like domain YrbL-PhoP_reg PF10707.9 EGE00560.1 - 0.0071 15.9 0.0 0.013 15.0 0.0 1.3 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL SRP-alpha_N PF04086.13 EGE00560.1 - 6.8 6.5 8.7 11 5.8 8.7 1.2 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Pro_isomerase PF00160.21 EGE00561.1 - 1.8e-51 174.5 0.1 4.1e-51 173.4 0.1 1.6 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD WD40 PF00400.32 EGE00561.1 - 1.3e-07 32.2 0.1 0.21 12.5 0.0 5.0 5 0 0 5 5 5 2 WD domain, G-beta repeat Cpn60_TCP1 PF00118.24 EGE00562.1 - 2.6e-139 465.0 12.7 3e-139 464.8 12.7 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Pam17 PF08566.10 EGE00565.1 - 1.8e-66 223.0 0.1 2.4e-66 222.6 0.1 1.1 1 0 0 1 1 1 1 Mitochondrial import protein Pam17 Fungal_trans_2 PF11951.8 EGE00566.1 - 2.9e-36 125.1 0.0 4.4e-36 124.5 0.0 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EGE00566.1 - 1.1e-08 35.0 11.1 2e-08 34.2 11.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SWIB PF02201.18 EGE00567.1 - 2.5e-28 97.8 0.0 5.6e-28 96.6 0.0 1.6 1 0 0 1 1 1 1 SWIB/MDM2 domain Mcm10 PF09332.11 EGE00567.1 - 0.017 14.5 5.4 0.022 14.2 5.4 1.1 1 0 0 1 1 1 0 Mcm10 replication factor RFXA_RFXANK_bdg PF15289.6 EGE00567.1 - 0.13 12.6 3.5 0.082 13.2 1.3 1.8 2 0 0 2 2 2 0 Regulatory factor X-associated C-terminal binding domain eIF2A PF08662.11 EGE00568.1 - 1.7e-36 125.9 5.9 2.6e-34 118.8 1.3 3.9 3 3 1 4 4 4 2 Eukaryotic translation initiation factor eIF2A RRM_1 PF00076.22 EGE00568.1 - 3.1e-07 30.1 0.1 8.6e-07 28.7 0.0 1.8 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) WD40 PF00400.32 EGE00568.1 - 0.0021 18.8 0.9 0.23 12.4 0.1 4.3 5 0 0 5 5 5 1 WD domain, G-beta repeat PRP3 PF08572.10 EGE00568.1 - 0.0061 16.3 0.1 0.014 15.1 0.1 1.6 1 0 0 1 1 1 1 pre-mRNA processing factor 3 (PRP3) DLH PF01738.18 EGE00569.1 - 4.5e-29 101.6 0.0 5.1e-29 101.4 0.0 1.0 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_1 PF00561.20 EGE00569.1 - 0.1 12.2 0.0 0.15 11.7 0.0 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold Abhydrolase_5 PF12695.7 EGE00569.1 - 0.11 12.2 0.0 0.32 10.7 0.0 1.7 2 0 0 2 2 2 0 Alpha/beta hydrolase family DUF2828 PF11443.8 EGE00571.1 - 3.3e-233 775.4 0.4 3.9e-233 775.1 0.4 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF2828) Het-C PF07217.11 EGE00572.1 - 3.5e-244 811.5 0.0 4.4e-244 811.2 0.0 1.1 1 0 0 1 1 1 1 Heterokaryon incompatibility protein Het-C Clr5 PF14420.6 EGE00573.1 - 5.3e-21 74.6 3.1 9.5e-21 73.8 0.6 2.6 2 0 0 2 2 2 1 Clr5 domain DUF4719 PF15843.5 EGE00575.1 - 0.4 10.8 2.2 0.49 10.5 2.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4719) Phytase-like PF13449.6 EGE00576.1 - 2.2e-40 139.4 0.1 2.7e-40 139.1 0.1 1.2 1 0 0 1 1 1 1 Esterase-like activity of phytase Mitofilin PF09731.9 EGE00577.1 - 3.8 6.2 17.1 5.8 5.6 17.1 1.2 1 0 0 1 1 1 0 Mitochondrial inner membrane protein DUF966 PF06136.13 EGE00577.1 - 5.9 6.5 11.9 9.3 5.9 11.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF966) Coatomer_WDAD PF04053.14 EGE00578.1 - 1.2e-141 472.8 0.0 1.8e-141 472.2 0.0 1.3 1 0 0 1 1 1 1 Coatomer WD associated region COPI_C PF06957.11 EGE00578.1 - 1.9e-108 362.8 0.0 3e-108 362.2 0.0 1.1 1 0 0 1 1 1 1 Coatomer (COPI) alpha subunit C-terminus WD40 PF00400.32 EGE00578.1 - 7.5e-33 112.0 21.1 1.8e-07 31.8 0.3 7.7 9 0 0 9 9 9 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EGE00578.1 - 6.8e-08 32.7 0.1 0.022 15.0 0.0 5.6 4 2 4 8 8 8 2 Anaphase-promoting complex subunit 4 WD40 domain Clathrin PF00637.20 EGE00578.1 - 0.0041 17.0 0.2 0.35 10.7 0.0 2.7 2 0 0 2 2 2 1 Region in Clathrin and VPS Nup160 PF11715.8 EGE00578.1 - 0.018 13.7 5.9 1.5 7.3 0.4 3.6 2 1 1 3 3 3 0 Nucleoporin Nup120/160 Evr1_Alr PF04777.13 EGE00579.1 - 7.7e-29 100.1 3.4 1.6e-28 99.1 3.4 1.5 1 0 0 1 1 1 1 Erv1 / Alr family Bd3614-deam PF14439.6 EGE00579.1 - 0.028 14.5 0.1 6.4 6.9 0.0 2.2 2 0 0 2 2 2 0 Bd3614-like deaminase DEK_C PF08766.11 EGE00580.1 - 0.0093 15.9 0.1 0.024 14.6 0.1 1.6 1 0 0 1 1 1 1 DEK C terminal domain CDC27 PF09507.10 EGE00580.1 - 0.54 9.6 36.6 0.8 9.0 36.6 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Adaptin_N PF01602.20 EGE00581.1 - 5.1e-130 434.5 3.1 6e-130 434.3 3.1 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 EGE00581.1 - 8.1e-65 217.8 2.4 1.2e-61 207.5 0.4 2.8 3 1 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EGE00581.1 - 6.1e-17 61.8 4.7 6.3e-07 29.7 0.0 5.7 4 2 2 6 6 6 4 HEAT repeats HEAT PF02985.22 EGE00581.1 - 5.8e-13 47.9 0.3 0.016 15.4 0.0 6.3 5 0 0 5 5 5 2 HEAT repeat HEAT_EZ PF13513.6 EGE00581.1 - 0.00073 20.0 5.3 0.7 10.5 0.0 6.0 7 1 1 8 8 8 1 HEAT-like repeat CLASP_N PF12348.8 EGE00581.1 - 0.0028 17.3 0.3 1.6 8.3 0.0 3.5 3 1 1 4 4 4 1 CLASP N terminal Arm PF00514.23 EGE00581.1 - 0.009 16.0 5.0 9 6.5 0.0 5.9 7 0 0 7 7 7 1 Armadillo/beta-catenin-like repeat RTP1_C1 PF10363.9 EGE00581.1 - 0.018 15.2 0.1 3.2 8.0 0.0 3.7 2 2 0 2 2 2 0 Required for nuclear transport of RNA pol II C-terminus 1 Ribosomal_60s PF00428.19 EGE00581.1 - 0.84 10.3 10.6 12 6.5 4.8 3.8 3 0 0 3 3 3 0 60s Acidic ribosomal protein TLD PF07534.16 EGE00582.1 - 4.3e-24 85.3 0.0 6.5e-15 55.6 0.0 2.2 2 0 0 2 2 2 2 TLD VID27_N PF17748.1 EGE00583.1 - 1.1e-75 253.3 0.3 1.1e-75 253.3 0.3 2.9 2 1 1 3 3 3 1 VID27 N-terminal region VID27 PF08553.10 EGE00583.1 - 3.1e-68 230.4 0.6 1e-51 176.1 0.1 2.4 1 1 1 2 2 2 2 VID27 C-terminal WD40-like domain VID27_PH PF17747.1 EGE00583.1 - 1.1e-47 160.8 0.8 5.5e-47 158.6 0.3 2.1 2 0 0 2 2 2 1 VID27 PH-like domain CDC45 PF02724.14 EGE00583.1 - 5.7 5.1 10.1 9.9 4.3 10.1 1.3 1 0 0 1 1 1 0 CDC45-like protein DNA_pol_phi PF04931.13 EGE00583.1 - 9.9 4.1 16.2 17 3.4 16.2 1.4 1 0 0 1 1 1 0 DNA polymerase phi tRNA_m1G_MT PF01746.21 EGE00584.1 - 3.2e-24 85.7 0.0 1.1e-22 80.7 0.0 2.4 1 1 0 1 1 1 1 tRNA (Guanine-1)-methyltransferase ApbA_C PF08546.11 EGE00584.1 - 0.07 13.3 0.0 0.17 12.1 0.0 1.6 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA C terminal Peptidase_M16 PF00675.20 EGE00584.1 - 0.19 11.7 0.8 0.41 10.6 0.8 1.5 1 0 0 1 1 1 0 Insulinase (Peptidase family M16) Rsc14 PF08586.10 EGE00584.1 - 0.56 11.1 3.3 2.1 9.2 3.3 1.9 1 0 0 1 1 1 0 RSC complex, Rsc14/Ldb7 subunit GRIM-19 PF06212.12 EGE00585.1 - 2.9e-20 72.6 0.3 1.1e-19 70.7 0.3 1.7 1 1 0 1 1 1 1 GRIM-19 protein Xpo1 PF08389.12 EGE00586.1 - 1.8e-13 50.8 4.3 9.1e-08 32.3 0.1 4.1 4 0 0 4 4 4 2 Exportin 1-like protein IBN_N PF03810.19 EGE00586.1 - 0.015 15.2 1.3 0.16 11.9 0.0 3.2 4 0 0 4 4 4 0 Importin-beta N-terminal domain Glyco_hydro_5_C PF18564.1 EGE00587.1 - 7.6e-23 80.9 0.0 1.7e-22 79.7 0.0 1.6 1 0 0 1 1 1 1 Glycoside hydrolase family 5 C-terminal domain Cellulase PF00150.18 EGE00587.1 - 3.5e-08 33.2 4.1 1.9e-06 27.5 1.8 2.7 2 1 0 2 2 2 2 Cellulase (glycosyl hydrolase family 5) EKLF_TAD1 PF16832.5 EGE00587.1 - 0.025 14.5 0.2 0.06 13.2 0.2 1.6 1 0 0 1 1 1 0 Erythroid krueppel-like transcription factor, transactivation 1 Glyco_hydro_42 PF02449.15 EGE00587.1 - 0.074 12.4 0.1 5.2 6.3 0.0 2.1 2 0 0 2 2 2 0 Beta-galactosidase TPR_17 PF13431.6 EGE00588.1 - 4.7e-21 73.6 12.0 0.13 12.7 0.0 13.0 14 0 0 14 14 14 5 Tetratricopeptide repeat TPR_1 PF00515.28 EGE00588.1 - 1.2e-17 62.8 35.9 0.026 14.3 0.1 13.7 15 1 0 15 15 15 7 Tetratricopeptide repeat TPR_2 PF07719.17 EGE00588.1 - 1.8e-17 61.9 49.0 0.032 14.3 0.1 15.5 17 0 0 17 17 15 6 Tetratricopeptide repeat TPR_19 PF14559.6 EGE00588.1 - 3.4e-16 59.5 20.7 0.00018 22.0 0.1 10.1 8 2 2 10 10 10 4 Tetratricopeptide repeat TPR_16 PF13432.6 EGE00588.1 - 6.3e-15 55.6 34.6 0.0043 17.7 0.2 11.1 11 1 0 11 11 10 5 Tetratricopeptide repeat TPR_11 PF13414.6 EGE00588.1 - 7.5e-15 54.3 18.2 0.013 15.2 0.0 9.8 8 1 1 9 9 9 4 TPR repeat TPR_14 PF13428.6 EGE00588.1 - 1.7e-14 53.3 32.9 0.12 13.3 0.0 15.3 13 4 6 19 19 15 3 Tetratricopeptide repeat TPR_12 PF13424.6 EGE00588.1 - 5.3e-14 52.3 37.6 0.055 13.8 0.2 12.3 10 3 2 13 13 13 6 Tetratricopeptide repeat TPR_8 PF13181.6 EGE00588.1 - 2.3e-09 36.7 39.1 0.092 13.0 0.4 11.8 13 0 0 13 13 12 5 Tetratricopeptide repeat TPR_6 PF13174.6 EGE00588.1 - 4.4e-07 30.1 19.7 0.93 10.3 0.2 12.1 13 0 0 13 13 12 1 Tetratricopeptide repeat TPR_7 PF13176.6 EGE00588.1 - 8.6e-05 22.3 8.9 7.5 6.8 0.0 7.9 7 0 0 7 7 6 1 Tetratricopeptide repeat TPR_9 PF13371.6 EGE00588.1 - 0.0012 18.9 4.8 11 6.2 0.1 6.1 5 0 0 5 5 5 0 Tetratricopeptide repeat Coatomer_E PF04733.14 EGE00588.1 - 0.026 14.0 0.2 0.12 11.7 0.2 2.2 1 0 0 1 1 1 0 Coatomer epsilon subunit DUF3465 PF11948.8 EGE00588.1 - 0.13 12.1 0.1 1.5 8.7 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3465) ANAPC5 PF12862.7 EGE00588.1 - 0.96 9.6 8.4 2.2 8.4 0.0 5.1 6 2 0 6 6 6 0 Anaphase-promoting complex subunit 5 TPR_10 PF13374.6 EGE00588.1 - 6 6.9 18.7 20 5.2 0.0 7.6 7 0 0 7 7 7 0 Tetratricopeptide repeat RMI1_N PF08585.12 EGE00589.1 - 3.9e-61 206.6 0.0 4.4e-61 206.4 0.0 1.0 1 0 0 1 1 1 1 RecQ mediated genome instability protein Vps51 PF08700.11 EGE00590.1 - 1.5e-24 85.9 0.0 3.2e-24 84.8 0.0 1.6 1 0 0 1 1 1 1 Vps51/Vps67 COG5 PF10392.9 EGE00590.1 - 0.0024 18.1 0.0 0.0043 17.2 0.0 1.4 1 0 0 1 1 1 1 Golgi transport complex subunit 5 Dor1 PF04124.12 EGE00590.1 - 0.022 13.4 0.1 0.031 13.0 0.1 1.1 1 0 0 1 1 1 0 Dor1-like family WD40 PF00400.32 EGE00591.1 - 0.0013 19.6 0.0 0.96 10.4 0.0 3.4 3 0 0 3 3 3 2 WD domain, G-beta repeat VP40 PF07447.12 EGE00591.1 - 0.14 11.3 0.0 0.35 9.9 0.0 1.6 2 0 0 2 2 2 0 Matrix protein VP40 CSN8_PSD8_EIF3K PF10075.9 EGE00592.1 - 2.5e-20 72.9 0.0 5.5e-20 71.8 0.0 1.4 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family SAC3_GANP PF03399.16 EGE00592.1 - 0.0092 15.4 0.0 0.012 15.0 0.0 1.2 1 0 0 1 1 1 1 SAC3/GANP family DUF2306 PF10067.9 EGE00593.1 - 1.4e-11 44.8 10.5 1.4e-11 44.8 10.5 1.6 2 0 0 2 2 2 1 Predicted membrane protein (DUF2306) Glyco_tran_28_C PF04101.16 EGE00593.1 - 0.11 12.4 0.1 0.2 11.6 0.1 1.3 1 0 0 1 1 1 0 Glycosyltransferase family 28 C-terminal domain Pro-kuma_activ PF09286.11 EGE00594.1 - 4.6e-35 121.0 0.0 1e-34 119.9 0.0 1.6 1 0 0 1 1 1 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.22 EGE00594.1 - 3.6e-07 29.7 0.0 1.1e-06 28.1 0.0 1.8 1 1 1 2 2 2 1 Subtilase family adh_short PF00106.25 EGE00595.1 - 2.1e-21 76.3 0.3 2.9e-21 75.8 0.3 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EGE00595.1 - 4.1e-16 59.2 0.1 5.6e-16 58.8 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EGE00595.1 - 0.00026 20.9 0.0 0.00038 20.4 0.0 1.3 1 0 0 1 1 1 1 KR domain Methyltransf_16 PF10294.9 EGE00596.1 - 5.7e-21 75.0 0.0 7.9e-21 74.6 0.0 1.2 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_25 PF13649.6 EGE00596.1 - 3.7e-05 24.3 0.0 6.8e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 EGE00596.1 - 5e-05 22.8 0.0 6.9e-05 22.4 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_23 PF13489.6 EGE00596.1 - 0.0015 18.4 0.0 0.0023 17.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EGE00596.1 - 0.0033 18.1 0.0 0.0059 17.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Met_10 PF02475.16 EGE00596.1 - 0.0039 17.0 0.0 0.006 16.4 0.0 1.2 1 0 0 1 1 1 1 Met-10+ like-protein MTS PF05175.14 EGE00596.1 - 0.0044 16.6 0.0 0.0075 15.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain TehB PF03848.14 EGE00596.1 - 0.015 14.7 0.0 0.027 13.9 0.0 1.3 1 0 0 1 1 1 0 Tellurite resistance protein TehB DUF938 PF06080.12 EGE00596.1 - 0.036 13.8 0.0 0.11 12.2 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF938) FtsJ PF01728.19 EGE00596.1 - 0.041 14.0 0.0 0.071 13.2 0.0 1.4 1 0 0 1 1 1 0 FtsJ-like methyltransferase Methyltransf_11 PF08241.12 EGE00596.1 - 0.056 14.1 0.0 0.099 13.3 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain RrnaAD PF00398.20 EGE00596.1 - 0.17 11.0 0.0 0.27 10.2 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase Methyltransf_31 PF13847.6 EGE00596.1 - 0.17 11.7 0.0 0.26 11.1 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Ribosomal_S24e PF01282.19 EGE00597.1 - 4.3e-33 113.1 0.1 7.5e-33 112.3 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein S24e Zn_clus PF00172.18 EGE00598.1 - 3.3e-08 33.5 5.8 8.6e-08 32.2 5.8 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Pro_isomerase PF00160.21 EGE00599.1 - 1.8e-21 77.0 0.0 1.7e-18 67.4 0.0 2.1 1 1 1 2 2 2 2 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD VGCC_beta4Aa_N PF12052.8 EGE00599.1 - 6.4 7.0 6.6 13 6.0 6.6 1.4 1 0 0 1 1 1 0 Voltage gated calcium channel subunit beta domain 4Aa N terminal UDPGP PF01704.18 EGE00600.1 - 2e-43 148.6 0.0 1.7e-42 145.6 0.0 2.0 1 1 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase NTP_transf_3 PF12804.7 EGE00600.1 - 0.015 15.6 0.1 0.045 14.1 0.0 2.0 2 1 0 2 2 2 0 MobA-like NTP transferase domain Fer4_20 PF14691.6 EGE00600.1 - 0.061 13.1 0.0 0.13 12.0 0.0 1.5 1 0 0 1 1 1 0 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster RPAP1_N PF08621.10 EGE00600.1 - 0.14 11.9 0.3 0.53 10.1 0.0 2.1 2 0 0 2 2 2 0 RPAP1-like, N-terminal MPDZ_u10 PF16667.5 EGE00600.1 - 0.15 13.0 2.0 0.26 12.2 0.9 2.1 2 0 0 2 2 2 0 Unstructured region 10 on multiple PDZ protein zf-CCHC PF00098.23 EGE00601.1 - 2.3e-33 112.8 39.4 1.9e-07 30.9 0.9 5.5 6 0 0 6 6 6 5 Zinc knuckle zf-CCHC_4 PF14392.6 EGE00601.1 - 7e-06 25.7 29.0 0.29 10.9 0.9 5.6 6 0 0 6 6 6 5 Zinc knuckle zf-CCHC_3 PF13917.6 EGE00601.1 - 0.00039 20.3 26.4 0.032 14.2 0.0 5.1 3 2 2 5 5 5 4 Zinc knuckle zf-CCHC_5 PF14787.6 EGE00601.1 - 0.016 14.9 0.9 0.016 14.9 0.9 5.4 4 1 2 6 6 6 0 GAG-polyprotein viral zinc-finger Rad51 PF08423.11 EGE00602.1 - 1.8e-113 378.0 0.0 2.3e-113 377.7 0.0 1.1 1 0 0 1 1 1 1 Rad51 RecA PF00154.21 EGE00602.1 - 2.3e-14 53.5 0.1 3e-14 53.1 0.1 1.1 1 0 0 1 1 1 1 recA bacterial DNA recombination protein HHH_5 PF14520.6 EGE00602.1 - 7.1e-08 32.9 1.5 1.1e-07 32.3 0.4 2.0 2 0 0 2 2 2 1 Helix-hairpin-helix domain ATPase PF06745.13 EGE00602.1 - 1.7e-07 30.9 0.0 3.7e-07 29.7 0.0 1.7 1 1 0 1 1 1 1 KaiC AAA_25 PF13481.6 EGE00602.1 - 4.9e-05 23.0 0.0 7.4e-05 22.4 0.0 1.2 1 0 0 1 1 1 1 AAA domain Phage_HK97_TLTM PF06120.11 EGE00602.1 - 0.0071 15.6 0.0 2.5 7.2 0.0 2.2 2 0 0 2 2 2 2 Tail length tape measure protein DnaB_bind PF10410.9 EGE00602.1 - 0.06 13.5 0.0 2.2 8.5 0.0 2.6 1 1 1 2 2 2 0 DnaB-helicase binding domain of primase DnaB_C PF03796.15 EGE00602.1 - 0.063 12.6 0.1 0.38 10.1 0.1 2.1 1 1 0 1 1 1 0 DnaB-like helicase C terminal domain FlgM PF04316.13 EGE00602.1 - 0.069 13.5 0.2 20 5.6 0.1 3.5 3 0 0 3 3 3 0 Anti-sigma-28 factor, FlgM AAA_24 PF13479.6 EGE00602.1 - 0.078 12.7 0.0 0.19 11.4 0.0 1.7 1 1 0 1 1 1 0 AAA domain NRD1_2 PF01995.16 EGE00602.1 - 0.1 11.9 0.0 0.19 10.9 0.0 1.4 1 0 0 1 1 1 0 NrpR regulatory domains NRD1 and 2 PAXNEB PF05625.11 EGE00602.1 - 0.17 11.0 0.0 1.3 8.1 0.0 2.0 2 0 0 2 2 2 0 PAXNEB protein RRP7 PF12923.7 EGE00603.1 - 2.1e-28 98.8 7.2 2.1e-28 98.8 7.2 2.3 3 0 0 3 3 3 1 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain RRM_Rrp7 PF17799.1 EGE00603.1 - 9.9e-28 97.0 0.0 1.6e-27 96.3 0.0 1.3 1 0 0 1 1 1 1 Rrp7 RRM-like N-terminal domain DUF5093 PF17011.5 EGE00603.1 - 0.18 12.1 0.0 0.18 12.1 0.0 2.3 3 0 0 3 3 3 0 Domain of unknown function (DUF5093) TFB6 PF17110.5 EGE00604.1 - 2e-40 138.3 0.0 3e-40 137.8 0.0 1.3 1 0 0 1 1 1 1 Subunit 11 of the general transcription factor TFIIH HEAT PF02985.22 EGE00605.1 - 1.2e-14 53.2 15.3 0.00011 22.2 0.0 8.6 10 1 0 10 10 8 2 HEAT repeat HEAT_2 PF13646.6 EGE00605.1 - 2.7e-11 43.7 1.4 0.00028 21.2 0.1 6.0 3 1 2 5 5 5 3 HEAT repeats HEAT_EZ PF13513.6 EGE00605.1 - 3.5e-11 43.3 3.7 1.3e-06 28.8 0.0 6.3 6 0 0 6 6 6 1 HEAT-like repeat CLASP_N PF12348.8 EGE00605.1 - 6.9e-07 29.1 1.3 0.028 14.0 0.0 4.0 4 0 0 4 4 4 2 CLASP N terminal DUF3385 PF11865.8 EGE00605.1 - 0.00021 21.2 1.8 3.2 7.6 0.5 4.1 4 0 0 4 4 4 2 Domain of unknown function (DUF3385) DRIM PF07539.12 EGE00605.1 - 0.00078 17.9 2.8 22 3.2 0.0 5.3 3 3 2 6 6 6 0 Down-regulated in metastasis Cse1 PF08506.10 EGE00605.1 - 0.011 14.6 0.0 1.9 7.2 0.0 3.2 3 0 0 3 3 3 0 Cse1 Arm PF00514.23 EGE00605.1 - 0.016 15.2 4.0 24 5.2 0.2 5.0 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat MMS19_N PF14500.6 EGE00605.1 - 0.025 14.2 2.4 2 7.9 0.8 2.9 3 0 0 3 3 3 0 Dos2-interacting transcription regulator of RNA-Pol-II Sec7_N PF12783.7 EGE00605.1 - 0.056 13.4 0.2 2.8 7.8 0.0 2.9 1 1 0 2 2 2 0 Guanine nucleotide exchange factor in Golgi transport N-terminal RGS PF00615.19 EGE00605.1 - 0.19 12.0 0.2 0.8 10.0 0.0 2.1 2 0 0 2 2 2 0 Regulator of G protein signaling domain NUC173 PF08161.12 EGE00605.1 - 0.36 10.5 3.5 61 3.2 0.0 4.1 4 1 0 5 5 5 0 NUC173 domain ANAPC4 PF12896.7 EGE00606.1 - 2e-62 210.3 1.5 3e-62 209.8 1.5 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 4 ANAPC4_WD40 PF12894.7 EGE00606.1 - 4.2e-30 103.9 0.0 4.1e-29 100.7 0.0 2.5 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain VWA PF00092.28 EGE00609.1 - 3e-08 34.1 0.0 4.2e-08 33.6 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 EGE00609.1 - 0.00014 22.5 0.0 0.00043 20.9 0.0 1.8 2 0 0 2 2 2 1 von Willebrand factor type A domain Tannase PF07519.11 EGE00610.1 - 1.4e-99 334.1 0.1 1.6e-99 333.9 0.1 1.0 1 0 0 1 1 1 1 Tannase and feruloyl esterase Abhydrolase_1 PF00561.20 EGE00610.1 - 0.0048 16.6 0.0 0.023 14.4 0.0 1.9 2 0 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EGE00610.1 - 0.15 11.3 0.0 0.26 10.5 0.0 1.4 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Zn_clus PF00172.18 EGE00611.1 - 6.1e-09 35.9 9.6 1.2e-08 34.9 9.6 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 EGE00611.1 - 4e-07 29.2 6.1 4.4e-06 25.7 0.2 3.1 2 1 1 3 3 3 2 Fungal specific transcription factor domain Tox-HNH-HHH PF15637.6 EGE00612.1 - 0.33 11.1 3.4 0.37 11.0 1.2 2.2 2 1 0 2 2 2 0 HNH/Endo VII superfamily nuclease toxin with a HHH motif APH PF01636.23 EGE00613.1 - 1.1e-12 48.5 0.0 1.6e-12 47.8 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Methyltransf_16 PF10294.9 EGE00614.1 - 2.3e-22 79.6 0.0 3.7e-22 78.9 0.0 1.3 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_23 PF13489.6 EGE00614.1 - 0.00067 19.5 0.0 0.001 18.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain ABC_tran PF00005.27 EGE00615.1 - 3.5e-26 92.3 0.0 4.1e-23 82.4 0.0 2.5 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 EGE00615.1 - 5.5e-12 46.1 0.4 0.0019 18.1 0.0 3.3 2 1 1 3 3 3 3 AAA domain, putative AbiEii toxin, Type IV TA system ABC_membrane PF00664.23 EGE00615.1 - 5.9e-09 36.0 2.6 8.6e-06 25.6 0.0 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region SMC_N PF02463.19 EGE00615.1 - 7.6e-08 32.1 0.2 0.00041 19.8 0.1 3.0 3 0 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_5 PF07728.14 EGE00615.1 - 0.049 13.6 0.5 25 4.9 0.1 2.9 2 1 1 3 3 3 0 AAA domain (dynein-related subfamily) VPS28 PF03997.12 EGE00616.1 - 7.6e-74 247.5 0.8 8.8e-74 247.3 0.8 1.0 1 0 0 1 1 1 1 VPS28 protein Noc2 PF03715.13 EGE00617.1 - 3.3e-128 427.1 0.1 1.1e-127 425.4 0.0 1.9 2 0 0 2 2 2 1 Noc2p family Nop14 PF04147.12 EGE00617.1 - 0.00067 18.0 0.5 0.00067 18.0 0.5 3.1 2 1 1 3 3 3 2 Nop14-like family Piwi PF02171.17 EGE00618.1 - 4.2e-72 242.9 0.0 6.2e-72 242.4 0.0 1.3 1 0 0 1 1 1 1 Piwi domain ArgoN PF16486.5 EGE00618.1 - 9.3e-18 65.2 0.9 3e-17 63.5 0.9 1.9 1 0 0 1 1 1 1 N-terminal domain of argonaute ArgoL1 PF08699.10 EGE00618.1 - 9.3e-16 57.2 0.0 2.9e-15 55.7 0.0 1.9 1 0 0 1 1 1 1 Argonaute linker 1 domain PAZ PF02170.22 EGE00618.1 - 8.1e-08 32.2 0.3 4.7e-07 29.7 0.0 2.5 3 0 0 3 3 3 1 PAZ domain ArgoL2 PF16488.5 EGE00618.1 - 3.2e-06 27.4 0.3 9e-06 25.9 0.1 2.0 2 0 0 2 2 2 1 Argonaute linker 2 domain MoaC PF01967.21 EGE00619.1 - 1.1e-43 148.6 0.1 1.8e-43 147.9 0.1 1.3 1 0 0 1 1 1 1 MoaC family Mob_synth_C PF06463.13 EGE00619.1 - 3.7e-37 127.1 0.0 4.4e-36 123.6 0.0 2.3 2 0 0 2 2 2 1 Molybdenum Cofactor Synthesis C Radical_SAM PF04055.21 EGE00619.1 - 2e-28 99.9 0.1 4e-28 98.9 0.1 1.5 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_12 PF13353.6 EGE00619.1 - 7.7e-05 23.0 0.0 0.00016 21.9 0.0 1.5 1 0 0 1 1 1 1 4Fe-4S single cluster domain AA_permease PF00324.21 EGE00621.1 - 1.2e-143 479.2 36.7 1.5e-143 478.9 36.7 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EGE00621.1 - 3.5e-36 124.9 38.4 4.2e-36 124.7 38.4 1.1 1 0 0 1 1 1 1 Amino acid permease ABC_tran PF00005.27 EGE00622.1 - 1.1e-08 35.7 0.0 2.3e-08 34.6 0.0 1.6 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 EGE00622.1 - 0.0003 20.7 0.0 0.00042 20.2 0.0 1.2 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EGE00622.1 - 0.00066 19.4 0.0 0.0014 18.3 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_23 PF13476.6 EGE00622.1 - 0.0049 17.4 0.0 0.0077 16.7 0.0 1.4 1 1 0 1 1 1 1 AAA domain AAA_28 PF13521.6 EGE00622.1 - 0.0055 17.0 0.0 0.0075 16.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.23 EGE00622.1 - 0.0094 16.0 0.1 0.019 15.0 0.1 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_27 PF13514.6 EGE00622.1 - 0.012 15.3 0.0 0.014 15.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 EGE00622.1 - 0.03 14.6 0.0 0.057 13.7 0.0 1.6 1 1 0 1 1 1 0 AAA domain FtsK_SpoIIIE PF01580.18 EGE00622.1 - 0.059 12.7 0.0 0.08 12.3 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_15 PF13175.6 EGE00622.1 - 0.072 12.8 0.0 0.12 12.1 0.0 1.5 2 0 0 2 2 2 0 AAA ATPase domain NACHT PF05729.12 EGE00622.1 - 0.077 12.9 0.0 0.22 11.4 0.0 1.9 2 0 0 2 2 2 0 NACHT domain AAA_5 PF07728.14 EGE00622.1 - 0.09 12.8 0.0 0.16 12.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 EGE00622.1 - 0.12 12.5 0.1 0.22 11.7 0.1 1.5 1 1 0 1 1 1 0 AAA domain Fer4_24 PF18109.1 EGE00622.1 - 0.13 12.5 0.1 0.23 11.8 0.1 1.3 1 0 0 1 1 1 0 Ferredoxin I 4Fe-4S cluster domain AAA_7 PF12775.7 EGE00622.1 - 0.13 11.7 0.0 0.27 10.7 0.0 1.5 2 0 0 2 2 2 0 P-loop containing dynein motor region 2OG-FeII_Oxy_3 PF13640.6 EGE00624.1 - 9.5e-08 32.8 0.0 1.7e-07 32.0 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily ANAPC4_WD40 PF12894.7 EGE00625.1 - 7.5e-08 32.6 0.2 0.00078 19.7 0.0 3.8 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EGE00625.1 - 1.7e-07 31.8 2.7 0.026 15.4 0.0 5.2 5 1 0 5 5 5 2 WD domain, G-beta repeat IKI3 PF04762.12 EGE00625.1 - 3e-05 22.3 0.0 5.4e-05 21.4 0.0 1.3 1 0 0 1 1 1 1 IKI3 family PD40 PF07676.12 EGE00625.1 - 0.059 13.3 1.5 1.1 9.3 0.1 3.2 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat Ribosomal_S25 PF03297.15 EGE00626.1 - 2e-27 95.3 1.5 2.5e-27 95.0 1.5 1.1 1 0 0 1 1 1 1 S25 ribosomal protein HTH_DeoR PF08220.12 EGE00626.1 - 0.0064 16.2 0.1 0.0095 15.7 0.1 1.2 1 0 0 1 1 1 1 DeoR-like helix-turn-helix domain Rrf2 PF02082.20 EGE00626.1 - 0.025 14.9 0.1 0.035 14.4 0.1 1.3 1 0 0 1 1 1 0 Transcriptional regulator HTH_11 PF08279.12 EGE00626.1 - 0.027 14.4 0.1 0.042 13.8 0.1 1.4 1 0 0 1 1 1 0 HTH domain HTH_24 PF13412.6 EGE00626.1 - 0.058 13.0 0.1 0.088 12.4 0.1 1.3 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding TrmB PF01978.19 EGE00626.1 - 0.087 12.7 0.2 0.14 12.1 0.2 1.4 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB MarR_2 PF12802.7 EGE00626.1 - 0.094 12.6 0.1 0.099 12.5 0.1 1.3 1 0 0 1 1 1 0 MarR family Cyt-b5 PF00173.28 EGE00627.1 - 5.7e-10 39.2 0.0 1.2e-09 38.2 0.0 1.7 1 1 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Gtr1_RagA PF04670.12 EGE00628.1 - 6e-70 235.2 0.4 9.2e-70 234.6 0.4 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Arf PF00025.21 EGE00628.1 - 5.3e-05 22.7 0.0 9.4e-05 21.9 0.0 1.4 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 EGE00628.1 - 0.0017 17.8 0.0 0.0043 16.5 0.0 1.6 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 EGE00628.1 - 0.0032 17.5 0.0 0.0073 16.4 0.0 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase Roc PF08477.13 EGE00628.1 - 0.007 16.6 0.0 0.014 15.6 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase ATP_bind_1 PF03029.17 EGE00628.1 - 0.031 14.1 0.2 0.05 13.4 0.2 1.4 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein Pkinase PF00069.25 EGE00629.1 - 1.3e-16 60.8 0.0 1.8e-16 60.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.23 EGE00629.1 - 0.0014 18.6 0.0 0.0022 18.0 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family His_Phos_2 PF00328.22 EGE00630.1 - 5.1e-13 49.1 0.0 1.8e-11 44.1 0.0 2.1 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) Lactamase_B_4 PF13691.6 EGE00631.1 - 1.8e-27 94.8 0.3 4.6e-26 90.3 0.1 2.8 3 0 0 3 3 3 1 tRNase Z endonuclease Lactamase_B_2 PF12706.7 EGE00631.1 - 2.4e-13 50.1 0.8 8.8e-06 25.4 0.1 2.3 1 1 0 2 2 2 2 Beta-lactamase superfamily domain Lactamase_B PF00753.27 EGE00631.1 - 0.00012 22.1 0.3 0.00028 21.0 0.3 1.6 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Methyltransf_25 PF13649.6 EGE00632.1 - 8.2e-19 68.1 0.1 6e-18 65.4 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EGE00632.1 - 4.9e-17 62.3 0.0 1.3e-14 54.6 0.0 2.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 EGE00632.1 - 6.6e-17 61.8 0.0 6.5e-15 55.3 0.0 2.3 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EGE00632.1 - 3.3e-15 56.6 0.0 2.5e-09 37.8 0.0 2.7 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_31 PF13847.6 EGE00632.1 - 3.8e-15 56.0 0.0 6.5e-12 45.5 0.0 2.3 2 0 0 2 2 2 2 Methyltransferase domain CMAS PF02353.20 EGE00632.1 - 1.1e-08 34.7 0.0 1.9e-08 33.9 0.0 1.4 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase NodS PF05401.11 EGE00632.1 - 1.7e-06 27.8 0.0 0.00013 21.7 0.0 2.2 2 0 0 2 2 2 1 Nodulation protein S (NodS) Pox_MCEL PF03291.16 EGE00632.1 - 1.2e-05 24.5 0.0 0.00013 21.2 0.0 2.3 1 1 0 1 1 1 1 mRNA capping enzyme MetW PF07021.12 EGE00632.1 - 3.4e-05 23.5 0.0 0.00052 19.7 0.0 2.1 2 0 0 2 2 2 1 Methionine biosynthesis protein MetW MTS PF05175.14 EGE00632.1 - 0.00015 21.3 0.0 0.0009 18.8 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_2 PF00891.18 EGE00632.1 - 0.0002 20.8 0.0 0.0045 16.3 0.0 2.2 2 0 0 2 2 2 1 O-methyltransferase domain CheR PF01739.18 EGE00632.1 - 0.00028 20.4 0.2 0.6 9.6 0.1 2.5 1 1 1 2 2 2 2 CheR methyltransferase, SAM binding domain Ubie_methyltran PF01209.18 EGE00632.1 - 0.0015 17.9 0.0 0.023 14.1 0.0 2.2 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_9 PF08003.11 EGE00632.1 - 0.0023 16.9 0.0 0.0037 16.3 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) TPMT PF05724.11 EGE00632.1 - 0.0023 17.6 0.0 0.0055 16.4 0.0 1.8 1 1 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) TehB PF03848.14 EGE00632.1 - 0.0078 15.6 0.0 0.017 14.5 0.0 1.5 1 0 0 1 1 1 1 Tellurite resistance protein TehB PCMT PF01135.19 EGE00632.1 - 0.014 15.2 0.0 0.038 13.7 0.0 1.7 1 1 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) GidB PF02527.15 EGE00632.1 - 0.017 14.5 0.0 6.4 6.1 0.0 2.2 2 0 0 2 2 2 0 rRNA small subunit methyltransferase G Methyltransf_32 PF13679.6 EGE00632.1 - 0.049 13.6 0.0 0.086 12.8 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain UPF0146 PF03686.13 EGE00632.1 - 0.081 12.8 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0146) Methyltransf_PK PF05891.12 EGE00632.1 - 0.12 11.9 0.0 0.25 10.8 0.0 1.5 1 0 0 1 1 1 0 AdoMet dependent proline di-methyltransferase SMYLE_N PF18615.1 EGE00634.1 - 0.015 14.9 6.5 0.018 14.6 6.5 1.1 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain TFIIA PF03153.13 EGE00634.1 - 0.75 9.7 19.9 0.94 9.4 19.9 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SelP_N PF04592.14 EGE00634.1 - 1.9 7.8 37.0 0.038 13.4 27.8 2.1 2 0 0 2 2 2 0 Selenoprotein P, N terminal region DUF3347 PF11827.8 EGE00634.1 - 8.8 6.5 12.9 6.1 7.0 7.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3347) ORC4_C PF14629.6 EGE00636.1 - 2.4e-43 148.1 0.0 3.9e-43 147.3 0.0 1.4 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 4 C-terminus AAA_16 PF13191.6 EGE00636.1 - 5.4e-15 56.2 0.9 2.8e-13 50.6 0.2 2.8 2 1 0 2 2 2 1 AAA ATPase domain DUF815 PF05673.13 EGE00636.1 - 0.00015 21.0 0.0 0.00025 20.3 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_19 PF13245.6 EGE00636.1 - 0.00033 21.0 0.2 0.00091 19.6 0.0 1.8 2 0 0 2 2 1 1 AAA domain AAA PF00004.29 EGE00636.1 - 0.00082 19.8 0.0 0.0026 18.2 0.0 1.8 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 EGE00636.1 - 0.00085 19.1 0.6 0.002 17.9 0.0 1.9 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 EGE00636.1 - 0.0011 19.0 0.0 0.0024 17.8 0.0 1.6 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 EGE00636.1 - 0.0021 18.3 0.1 0.04 14.2 0.1 2.5 1 1 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 EGE00636.1 - 0.059 12.7 0.0 0.11 11.8 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_7 PF12775.7 EGE00636.1 - 0.072 12.6 0.0 0.19 11.2 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region FtsK_SpoIIIE PF01580.18 EGE00636.1 - 0.11 11.8 0.0 0.2 11.0 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family PIF1 PF05970.14 EGE00636.1 - 0.2 10.8 0.0 0.34 10.0 0.0 1.3 1 0 0 1 1 1 0 PIF1-like helicase AF-4 PF05110.13 EGE00636.1 - 0.65 8.0 21.8 0.91 7.5 21.8 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein DUF3439 PF11921.8 EGE00636.1 - 3.2 7.7 6.8 9.3 6.2 6.8 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) SET PF00856.28 EGE00637.1 - 1.2e-06 29.1 4.2 4.1e-06 27.3 0.7 3.0 2 1 0 2 2 2 1 SET domain PHD PF00628.29 EGE00637.1 - 5.5e-06 26.2 9.6 1.3e-05 24.9 9.6 1.7 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 EGE00637.1 - 0.44 10.1 5.4 0.85 9.2 5.4 1.5 1 0 0 1 1 1 0 PHD-finger Ferlin_C PF16165.5 EGE00638.1 - 8.4 6.3 6.6 11 5.9 6.6 1.2 1 0 0 1 1 1 0 Ferlin C-terminus ArfGap PF01412.18 EGE00639.1 - 3e-36 124.0 0.0 5.7e-36 123.1 0.0 1.4 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf UBA PF00627.31 EGE00639.1 - 0.11 12.4 0.0 0.87 9.6 0.0 2.3 2 0 0 2 2 2 0 UBA/TS-N domain Glyco_transf_22 PF03901.17 EGE00640.1 - 6.6e-82 276.0 18.2 8.1e-82 275.7 18.2 1.1 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family Aminotran_3 PF00202.21 EGE00641.1 - 1e-116 389.9 0.0 1.2e-116 389.7 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Beta_elim_lyase PF01212.21 EGE00641.1 - 0.0073 15.6 0.0 0.014 14.7 0.0 1.4 1 0 0 1 1 1 1 Beta-eliminating lyase ABC_membrane PF00664.23 EGE00642.1 - 5.1e-63 213.3 33.8 2.6e-39 135.5 19.0 3.1 3 0 0 3 3 3 3 ABC transporter transmembrane region ABC_tran PF00005.27 EGE00642.1 - 3.3e-47 160.4 0.9 5.6e-27 94.9 0.2 3.5 3 0 0 3 3 3 2 ABC transporter MMR_HSR1 PF01926.23 EGE00642.1 - 2.6e-06 27.5 0.8 0.02 15.0 0.1 3.0 2 0 0 2 2 2 2 50S ribosome-binding GTPase SMC_N PF02463.19 EGE00642.1 - 3.9e-05 23.2 6.4 0.13 11.7 2.1 4.1 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EGE00642.1 - 4e-05 23.6 1.1 0.27 11.0 0.1 3.7 2 1 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 EGE00642.1 - 7.8e-05 23.1 0.3 0.29 11.5 0.0 2.8 2 1 0 2 2 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 EGE00642.1 - 0.0001 22.3 0.2 0.14 12.1 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase AAA_23 PF13476.6 EGE00642.1 - 0.00028 21.4 0.9 0.32 11.5 0.1 2.9 3 0 0 3 3 2 2 AAA domain AAA_29 PF13555.6 EGE00642.1 - 0.00054 19.7 1.3 0.39 10.5 0.1 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain Zeta_toxin PF06414.12 EGE00642.1 - 0.0017 17.7 0.0 0.3 10.3 0.0 2.4 2 0 0 2 2 2 1 Zeta toxin MeaB PF03308.16 EGE00642.1 - 0.0027 16.7 2.1 0.5 9.3 0.1 2.4 2 0 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB Dynamin_N PF00350.23 EGE00642.1 - 0.0036 17.4 2.2 0.24 11.5 0.1 2.5 2 0 0 2 2 2 1 Dynamin family YqzM PF14141.6 EGE00642.1 - 0.0086 16.1 0.1 0.027 14.5 0.1 1.9 1 0 0 1 1 1 1 YqzM-like protein AAA_15 PF13175.6 EGE00642.1 - 0.012 15.4 0.4 4.5 6.9 0.0 2.4 2 0 0 2 2 2 0 AAA ATPase domain AAA_22 PF13401.6 EGE00642.1 - 0.014 15.7 0.5 4.9 7.4 0.1 3.1 3 0 0 3 3 3 0 AAA domain AAA_18 PF13238.6 EGE00642.1 - 0.037 14.6 0.0 5.4 7.6 0.0 2.7 2 0 0 2 2 2 0 AAA domain DUF87 PF01935.17 EGE00642.1 - 0.047 13.8 3.9 0.12 12.5 0.5 2.5 2 0 0 2 2 2 0 Helicase HerA, central domain IstB_IS21 PF01695.17 EGE00642.1 - 0.056 13.2 0.1 1.9 8.2 0.0 2.4 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_30 PF13604.6 EGE00642.1 - 0.094 12.4 2.2 3.1 7.5 0.2 2.8 2 0 0 2 2 2 0 AAA domain Roc PF08477.13 EGE00642.1 - 0.15 12.3 0.1 27 5.0 0.1 3.0 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Ploopntkinase3 PF18751.1 EGE00642.1 - 0.16 11.9 0.8 21 5.0 0.1 2.5 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 AAA_28 PF13521.6 EGE00642.1 - 0.43 10.8 0.0 0.43 10.8 0.0 2.8 4 0 0 4 4 2 0 AAA domain NB-ARC PF00931.22 EGE00642.1 - 0.57 9.3 2.1 13 4.9 0.2 2.5 2 0 0 2 2 2 0 NB-ARC domain AA_permease_2 PF13520.6 EGE00643.1 - 4.7e-45 154.2 45.8 1.2e-44 152.8 43.9 2.0 1 1 0 1 1 1 1 Amino acid permease Tyr-DNA_phospho PF06087.12 EGE00644.1 - 3.1e-163 543.6 0.0 3.6e-163 543.4 0.0 1.0 1 0 0 1 1 1 1 Tyrosyl-DNA phosphodiesterase PLDc_2 PF13091.6 EGE00644.1 - 0.0037 17.2 0.0 0.84 9.5 0.0 2.4 2 0 0 2 2 2 2 PLD-like domain ACBP PF00887.19 EGE00645.1 - 3e-19 69.0 0.5 3.9e-19 68.7 0.5 1.1 1 0 0 1 1 1 1 Acyl CoA binding protein U-box PF04564.15 EGE00646.1 - 3.6e-24 84.7 0.1 6.9e-24 83.8 0.1 1.5 1 0 0 1 1 1 1 U-box domain TPR_11 PF13414.6 EGE00646.1 - 4.4e-09 35.9 1.0 1.1e-08 34.6 0.2 2.1 2 0 0 2 2 2 1 TPR repeat TPR_2 PF07719.17 EGE00646.1 - 1.8e-08 33.9 3.6 0.0002 21.2 1.3 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 EGE00646.1 - 2.1e-07 31.5 1.2 0.00013 22.6 0.0 2.4 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 EGE00646.1 - 1.4e-06 27.8 2.9 8.5e-05 22.2 1.5 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 EGE00646.1 - 2.5e-06 27.9 0.2 0.0012 19.3 0.0 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat CHIP_TPR_N PF18391.1 EGE00646.1 - 7e-06 26.7 5.5 1.2e-05 25.9 5.5 1.4 1 0 0 1 1 1 1 CHIP N-terminal tetratricopeptide repeat domain TPR_12 PF13424.6 EGE00646.1 - 4.1e-05 23.8 1.7 0.014 15.6 0.1 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 EGE00646.1 - 0.001 19.7 0.0 0.47 11.4 0.0 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat zf-Nse PF11789.8 EGE00646.1 - 0.0029 17.4 0.1 0.0095 15.7 0.1 1.8 1 1 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_UBOX PF13445.6 EGE00646.1 - 0.011 15.8 0.0 0.02 14.9 0.0 1.4 1 0 0 1 1 1 0 RING-type zinc-finger TPR_17 PF13431.6 EGE00646.1 - 0.011 16.1 2.4 0.092 13.2 0.0 3.0 3 0 0 3 3 2 0 Tetratricopeptide repeat zf-NOSIP PF15906.5 EGE00646.1 - 0.012 15.8 0.0 0.021 15.0 0.0 1.5 1 0 0 1 1 1 0 Zinc-finger of nitric oxide synthase-interacting protein FCH PF00611.23 EGE00646.1 - 0.031 14.6 0.1 0.11 12.9 0.0 1.9 2 0 0 2 2 2 0 Fes/CIP4, and EFC/F-BAR homology domain TPR_10 PF13374.6 EGE00646.1 - 0.037 13.9 0.3 16 5.5 0.0 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EGE00646.1 - 0.047 13.9 0.1 14 6.0 0.0 2.6 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TIM PF00121.18 EGE00649.1 - 5.9e-41 140.4 0.0 1.4e-40 139.2 0.0 1.6 1 1 0 1 1 1 1 Triosephosphate isomerase LacAB_rpiB PF02502.18 EGE00650.1 - 1.9e-43 147.8 0.1 2.2e-43 147.6 0.1 1.0 1 0 0 1 1 1 1 Ribose/Galactose Isomerase DUF2620 PF10941.8 EGE00650.1 - 0.032 14.4 0.0 0.037 14.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function DUF2620 DHO_dh PF01180.21 EGE00651.1 - 2.6e-63 214.0 0.5 4.6e-55 186.9 0.0 2.1 2 0 0 2 2 2 2 Dihydroorotate dehydrogenase FMN_dh PF01070.18 EGE00651.1 - 0.003 16.6 0.8 0.011 14.8 0.8 1.9 1 1 0 1 1 1 1 FMN-dependent dehydrogenase PcrB PF01884.17 EGE00651.1 - 0.14 11.6 0.4 4.2 6.8 0.0 2.3 2 0 0 2 2 2 0 PcrB family Mnd1 PF03962.15 EGE00652.1 - 2.1e-21 75.9 0.1 8.7e-21 74.0 0.0 2.0 2 0 0 2 2 2 1 Mnd1 HTH domain LZ3wCH PF18517.1 EGE00652.1 - 0.00067 19.7 0.3 0.0025 17.9 0.3 2.0 1 0 0 1 1 1 1 Leucine zipper with capping helix domain Gp-FAR-1 PF05823.12 EGE00652.1 - 0.029 14.7 1.7 8 6.8 0.0 3.0 2 1 0 3 3 3 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) DUF5395 PF17373.2 EGE00652.1 - 0.062 13.9 0.2 0.2 12.3 0.1 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5395) BRE1 PF08647.11 EGE00652.1 - 0.23 11.6 13.1 1.8 8.7 8.1 3.3 3 1 0 3 3 3 0 BRE1 E3 ubiquitin ligase HTH_38 PF13936.6 EGE00652.1 - 0.41 10.4 3.2 15 5.5 0.0 3.8 4 0 0 4 4 4 0 Helix-turn-helix domain DivIC PF04977.15 EGE00652.1 - 1.1 9.1 16.0 0.93 9.3 2.1 3.6 2 1 2 4 4 4 0 Septum formation initiator DUF1843 PF08898.10 EGE00652.1 - 1.1 9.8 4.0 10 6.7 0.4 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF1843) SlyX PF04102.12 EGE00652.1 - 5.5 7.7 6.2 23 5.7 1.3 3.0 2 1 0 2 2 2 0 SlyX Fib_alpha PF08702.10 EGE00652.1 - 7.9 6.7 7.9 1.3 9.2 3.4 2.0 3 0 0 3 3 3 0 Fibrinogen alpha/beta chain family UAF_Rrn10 PF05234.11 EGE00653.1 - 7.7e-05 22.9 0.0 0.00013 22.2 0.0 1.4 1 0 0 1 1 1 1 UAF complex subunit Rrn10 WD40 PF00400.32 EGE00654.1 - 2.2e-15 56.7 18.8 1.3e-05 25.8 0.5 6.2 6 1 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EGE00654.1 - 4.6e-12 46.1 0.5 0.0068 16.7 0.0 4.8 3 1 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Fungal_trans_2 PF11951.8 EGE00655.1 - 2.8e-100 335.9 0.2 3.4e-100 335.5 0.2 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EGE00655.1 - 1.4e-06 28.3 8.8 2.9e-06 27.3 8.8 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SAM_2 PF07647.17 EGE00659.1 - 8.3e-11 41.8 0.1 1.5e-10 41.0 0.1 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 EGE00659.1 - 4.4e-08 33.5 0.2 8.5e-08 32.5 0.2 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_Ste50p PF09235.10 EGE00659.1 - 0.0043 17.3 0.0 0.0072 16.6 0.0 1.3 1 0 0 1 1 1 1 Ste50p, sterile alpha motif SAM_PNT PF02198.16 EGE00659.1 - 0.0074 16.2 0.1 0.018 15.0 0.1 1.7 2 0 0 2 2 2 1 Sterile alpha motif (SAM)/Pointed domain SAM_3 PF18016.1 EGE00659.1 - 0.19 11.5 0.0 0.46 10.3 0.0 1.7 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) PH_6 PF15406.6 EGE00660.1 - 0.01 16.1 0.0 0.014 15.7 0.0 1.2 1 0 0 1 1 1 0 Pleckstrin homology domain PH PF00169.29 EGE00660.1 - 0.074 13.6 0.0 0.096 13.2 0.0 1.2 1 0 0 1 1 1 0 PH domain eIF-5_eIF-2B PF01873.17 EGE00662.1 - 6.4e-41 138.9 0.1 1.1e-40 138.1 0.1 1.4 1 0 0 1 1 1 1 Domain found in IF2B/IF5 zf-HYPF PF07503.12 EGE00662.1 - 0.35 10.7 2.8 12 5.8 0.0 2.7 3 0 0 3 3 3 0 HypF finger Arc_trans_TRASH PF08394.10 EGE00662.1 - 1.2 9.6 7.4 1.1 9.6 0.3 2.7 1 1 1 2 2 2 0 Archaeal TRASH domain DUF2894 PF11445.8 EGE00662.1 - 1.2 9.6 5.6 26 5.2 5.6 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF2894) AIM24 PF01987.17 EGE00663.1 - 4e-54 183.5 0.5 4.8e-54 183.2 0.5 1.0 1 0 0 1 1 1 1 Mitochondrial biogenesis AIM24 bZIP_1 PF00170.21 EGE00666.1 - 3.5e-06 27.0 4.8 7.3e-06 26.0 4.8 1.5 1 0 0 1 1 1 1 bZIP transcription factor Ras PF00071.22 EGE00667.1 - 1.1e-40 138.9 0.0 1.5e-40 138.4 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EGE00667.1 - 1.7e-28 99.3 0.0 2.3e-28 98.8 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EGE00667.1 - 6.1e-12 45.3 0.0 2.4e-11 43.4 0.0 1.7 2 0 0 2 2 2 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EGE00667.1 - 0.00011 22.2 0.0 0.00017 21.6 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EGE00667.1 - 0.00028 20.3 0.0 0.00038 19.9 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EGE00667.1 - 0.00032 20.3 0.0 0.0019 17.8 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EGE00667.1 - 0.0042 17.0 0.0 0.042 13.8 0.0 2.2 2 0 0 2 2 2 1 RsgA GTPase SRPRB PF09439.10 EGE00667.1 - 0.01 15.3 0.0 0.02 14.3 0.0 1.4 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit NACHT PF05729.12 EGE00667.1 - 0.011 15.7 0.1 0.31 10.9 0.0 2.2 2 0 0 2 2 2 0 NACHT domain ABC_tran PF00005.27 EGE00667.1 - 0.023 15.2 0.0 0.043 14.3 0.0 1.4 1 0 0 1 1 1 0 ABC transporter AAA_33 PF13671.6 EGE00667.1 - 0.024 14.8 0.0 0.049 13.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain PduV-EutP PF10662.9 EGE00667.1 - 0.036 13.8 0.0 0.95 9.2 0.0 2.2 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_16 PF13191.6 EGE00667.1 - 0.057 13.8 0.2 0.44 10.9 0.0 2.2 1 1 0 2 2 2 0 AAA ATPase domain AAA_22 PF13401.6 EGE00667.1 - 0.12 12.6 0.0 0.26 11.6 0.0 1.6 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 EGE00667.1 - 0.21 11.1 0.0 0.33 10.5 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region ADH_N PF08240.12 EGE00668.1 - 1.7e-32 111.6 2.6 2.4e-32 111.1 0.3 2.1 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EGE00668.1 - 1.8e-23 83.0 0.0 3.5e-23 82.0 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 EGE00668.1 - 2.4e-07 30.5 0.1 5.2e-07 29.4 0.1 1.5 1 1 0 1 1 1 1 Glucose dehydrogenase C-terminus ADH_zinc_N_2 PF13602.6 EGE00668.1 - 0.00019 22.5 0.0 0.00055 21.0 0.0 1.8 1 0 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 EGE00668.1 - 0.0014 17.9 0.2 0.0024 17.2 0.2 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain UDPG_MGDP_dh_N PF03721.14 EGE00668.1 - 0.0051 16.4 0.0 0.0084 15.7 0.0 1.3 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain FtsJ PF01728.19 EGE00668.1 - 0.015 15.4 0.0 0.021 14.9 0.0 1.3 1 0 0 1 1 1 0 FtsJ-like methyltransferase Methyltransf_25 PF13649.6 EGE00668.1 - 0.027 15.2 0.0 0.059 14.1 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Pyr_redox_2 PF07992.14 EGE00668.1 - 0.029 13.6 0.0 0.041 13.1 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EGE00668.1 - 0.066 11.9 0.1 0.091 11.4 0.1 1.1 1 0 0 1 1 1 0 HI0933-like protein AdoHcyase_NAD PF00670.21 EGE00668.1 - 0.079 13.0 0.3 0.67 10.0 0.2 2.2 2 0 0 2 2 2 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain PrmA PF06325.13 EGE00668.1 - 0.088 12.2 0.0 0.13 11.6 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Mannosidase_ig PF17786.1 EGE00669.1 - 1e-16 61.3 0.3 4e-15 56.2 0.0 2.5 2 0 0 2 2 2 1 Mannosidase Ig/CBM-like domain Glyco_hydro_2 PF00703.21 EGE00669.1 - 6.4e-13 49.3 0.0 8.3e-12 45.8 0.0 2.3 2 0 0 2 2 2 1 Glycosyl hydrolases family 2 Glyco_hydro_2_N PF02837.18 EGE00669.1 - 6.3e-06 26.2 0.0 2.7e-05 24.1 0.0 2.0 2 0 0 2 2 2 1 Glycosyl hydrolases family 2, sugar binding domain Ig_mannosidase PF17753.1 EGE00669.1 - 0.00021 21.0 0.0 0.00097 18.8 0.0 2.1 2 0 0 2 2 2 1 Ig-fold domain FAD-oxidase_C PF02913.19 EGE00670.1 - 6.7e-60 202.8 0.1 1.3e-59 201.9 0.1 1.5 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 EGE00670.1 - 1e-25 90.1 0.1 5.2e-24 84.6 0.1 2.3 1 1 0 1 1 1 1 FAD binding domain EST1_DNA_bind PF10373.9 EGE00671.1 - 2.5e-07 30.5 0.0 0.0024 17.4 0.0 2.2 2 0 0 2 2 2 2 Est1 DNA/RNA binding domain ER_lumen_recept PF00810.18 EGE00671.1 - 0.21 12.4 0.5 0.94 10.3 0.0 2.1 2 1 0 2 2 2 0 ER lumen protein retaining receptor SUIM_assoc PF16619.5 EGE00675.1 - 0.19 11.8 9.3 0.81 9.8 8.6 2.4 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Macoilin PF09726.9 EGE00675.1 - 0.42 9.1 6.5 0.56 8.7 6.5 1.1 1 0 0 1 1 1 0 Macoilin family TFIIA PF03153.13 EGE00675.1 - 0.66 9.9 12.5 0.86 9.5 12.5 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PAT1 PF09770.9 EGE00675.1 - 1.8 6.7 8.3 2.2 6.4 8.3 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 PAF-AH_p_II PF03403.13 EGE00677.1 - 6.1e-16 57.9 0.0 2.8e-08 32.7 0.0 2.1 2 0 0 2 2 2 2 Platelet-activating factor acetylhydrolase, isoform II Chlorophyllase2 PF12740.7 EGE00677.1 - 2.3e-05 23.4 0.0 3.9e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 Chlorophyllase enzyme Hydrolase_4 PF12146.8 EGE00677.1 - 2.3e-05 23.8 0.0 0.088 12.1 0.1 2.4 2 1 0 3 3 3 2 Serine aminopeptidase, S33 Abhydrolase_5 PF12695.7 EGE00677.1 - 0.018 14.8 0.0 1.1 9.0 0.0 2.2 2 0 0 2 2 2 0 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EGE00677.1 - 0.068 12.8 0.1 0.42 10.2 0.1 2.0 1 1 0 1 1 1 0 alpha/beta hydrolase fold Chlorophyllase PF07224.11 EGE00677.1 - 0.11 11.5 0.1 0.2 10.6 0.1 1.3 1 1 0 1 1 1 0 Chlorophyllase AP_endonuc_2 PF01261.24 EGE00677.1 - 0.11 11.9 0.0 0.19 11.2 0.0 1.3 1 0 0 1 1 1 0 Xylose isomerase-like TIM barrel Methyltransf_34 PF11312.8 EGE00678.1 - 3.1e-99 332.1 0.0 3.8e-99 331.8 0.0 1.2 1 0 0 1 1 1 1 Putative SAM-dependent methyltransferase DUF2228 PF10228.9 EGE00679.1 - 0.2 11.4 0.0 0.28 10.9 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2228) Band_7 PF01145.25 EGE00680.1 - 1.8e-24 86.8 8.1 4.1e-24 85.6 8.1 1.6 1 1 0 1 1 1 1 SPFH domain / Band 7 family YdfA_immunity PF12127.8 EGE00680.1 - 0.00088 18.4 4.2 0.0012 17.9 4.2 1.3 1 0 0 1 1 1 1 SigmaW regulon antibacterial GatB_Yqey PF02637.18 EGE00680.1 - 0.023 14.6 0.6 0.04 13.8 0.6 1.4 1 0 0 1 1 1 0 GatB domain UcrQ PF02939.16 EGE00681.1 - 2.3e-33 114.0 0.4 2.6e-33 113.8 0.4 1.0 1 0 0 1 1 1 1 UcrQ family Ribosomal_L7Ae PF01248.26 EGE00682.1 - 3.2e-18 65.2 1.3 3.2e-18 65.2 1.3 2.5 2 1 0 2 2 2 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Rib_recp_KP_reg PF05104.12 EGE00682.1 - 0.013 16.5 15.5 0.013 16.5 15.5 2.2 2 0 0 2 2 2 0 Ribosome receptor lysine/proline rich region FSIP1 PF15554.6 EGE00684.1 - 0.22 10.6 0.0 0.26 10.4 0.0 1.1 1 0 0 1 1 1 0 FSIP1 family MMR_HSR1_C PF08438.10 EGE00685.1 - 1.4e-36 125.4 0.0 3.1e-36 124.3 0.0 1.6 1 0 0 1 1 1 1 GTPase of unknown function C-terminal MMR_HSR1 PF01926.23 EGE00685.1 - 1.5e-17 63.7 0.0 6.7e-17 61.6 0.0 2.0 1 1 1 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EGE00685.1 - 1.9e-05 24.2 0.0 0.00065 19.3 0.0 2.5 2 0 0 2 2 2 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 EGE00685.1 - 0.0062 16.5 1.4 0.12 12.2 0.1 2.4 2 0 0 2 2 2 1 RsgA GTPase GTP_EFTU PF00009.27 EGE00685.1 - 0.0079 15.8 1.1 0.58 9.7 0.0 2.7 3 0 0 3 3 3 1 Elongation factor Tu GTP binding domain ATP_bind_1 PF03029.17 EGE00685.1 - 0.024 14.4 0.1 7.7 6.2 0.0 2.3 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein ABC_tran PF00005.27 EGE00685.1 - 0.051 14.1 0.3 0.83 10.2 0.0 2.3 2 0 0 2 2 2 0 ABC transporter MeaB PF03308.16 EGE00685.1 - 0.051 12.5 0.4 0.19 10.7 0.0 2.0 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Dynamin_N PF00350.23 EGE00685.1 - 0.068 13.2 2.4 0.29 11.2 0.5 2.5 3 0 0 3 3 3 0 Dynamin family Ploopntkinase3 PF18751.1 EGE00685.1 - 0.11 12.4 0.0 0.23 11.4 0.0 1.5 1 0 0 1 1 1 0 P-loop Nucleotide Kinase3 AAA_16 PF13191.6 EGE00685.1 - 0.12 12.7 0.0 0.33 11.3 0.0 1.8 1 0 0 1 1 1 0 AAA ATPase domain KTI12 PF08433.10 EGE00685.1 - 0.12 11.8 0.1 0.32 10.4 0.0 1.7 2 0 0 2 2 2 0 Chromatin associated protein KTI12 MMR_HSR1_Xtn PF16897.5 EGE00685.1 - 0.13 12.3 0.2 0.33 11.0 0.1 1.7 2 0 0 2 2 2 0 C-terminal region of MMR_HSR1 domain SET PF00856.28 EGE00687.1 - 0.0015 19.0 0.0 0.0037 17.6 0.0 1.8 2 1 0 2 2 2 1 SET domain Fungal_trans PF04082.18 EGE00690.1 - 3e-31 108.4 0.7 5.7e-31 107.5 0.7 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EGE00690.1 - 1.4e-09 37.9 11.7 2.1e-09 37.3 11.7 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Trimer_CC PF08954.11 EGE00690.1 - 0.022 14.3 1.5 0.063 12.9 1.5 1.8 1 0 0 1 1 1 0 Trimerisation motif bZIP_1 PF00170.21 EGE00690.1 - 0.21 11.7 0.6 0.56 10.3 0.1 1.9 2 0 0 2 2 2 0 bZIP transcription factor PKcGMP_CC PF16808.5 EGE00690.1 - 1.6 8.6 4.1 1 9.3 1.3 2.0 1 1 1 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Transketolase_N PF00456.21 EGE00691.1 - 1.4e-146 487.7 0.1 3.2e-146 486.6 0.1 1.6 1 1 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain Transket_pyr PF02779.24 EGE00691.1 - 3.1e-46 157.3 0.0 5.2e-46 156.6 0.0 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain DXP_synthase_N PF13292.6 EGE00691.1 - 1.6e-05 24.3 0.0 4e-05 23.0 0.0 1.5 1 1 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase Transketolase_C PF02780.20 EGE00691.1 - 0.00099 19.0 0.1 0.0022 17.8 0.1 1.7 1 0 0 1 1 1 1 Transketolase, C-terminal domain E1_dh PF00676.20 EGE00691.1 - 0.028 13.3 0.3 0.045 12.7 0.3 1.2 1 0 0 1 1 1 0 Dehydrogenase E1 component Beta_elim_lyase PF01212.21 EGE00691.1 - 0.11 11.8 0.0 0.21 10.8 0.0 1.4 1 0 0 1 1 1 0 Beta-eliminating lyase TPP_enzyme_C PF02775.21 EGE00691.1 - 0.5 10.1 8.6 0.097 12.5 1.8 2.6 2 1 0 2 2 2 0 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain Spermine_synth PF01564.17 EGE00692.1 - 3.8e-65 218.8 0.0 5.1e-65 218.4 0.0 1.1 1 0 0 1 1 1 1 Spermine/spermidine synthase domain Spermine_synt_N PF17284.2 EGE00692.1 - 3e-23 81.4 0.1 5.6e-23 80.6 0.1 1.5 1 0 0 1 1 1 1 Spermidine synthase tetramerisation domain Methyltransf_25 PF13649.6 EGE00692.1 - 9.5e-05 23.0 0.0 0.00025 21.7 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EGE00692.1 - 0.00084 19.2 0.0 0.0013 18.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EGE00692.1 - 0.0012 19.5 0.2 0.0058 17.3 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain DUF43 PF01861.16 EGE00692.1 - 0.0071 15.6 0.0 0.011 15.0 0.0 1.2 1 0 0 1 1 1 1 Branched-chain polyamine synthase A C-terminal domain MTS PF05175.14 EGE00692.1 - 0.063 12.8 0.0 0.082 12.4 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_18 PF12847.7 EGE00692.1 - 0.11 12.4 0.0 0.2 11.6 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain bZIP_1 PF00170.21 EGE00693.1 - 9.8e-09 35.2 9.7 1.7e-08 34.5 9.7 1.3 1 0 0 1 1 1 1 bZIP transcription factor TMF_TATA_bd PF12325.8 EGE00693.1 - 0.00012 22.3 1.6 0.00016 21.8 1.6 1.2 1 0 0 1 1 1 1 TATA element modulatory factor 1 TATA binding bZIP_2 PF07716.15 EGE00693.1 - 0.0018 18.3 7.2 0.0018 18.3 7.2 2.1 1 1 1 2 2 2 1 Basic region leucine zipper SKA1 PF07160.12 EGE00693.1 - 0.0044 16.9 1.6 0.0064 16.4 1.6 1.2 1 0 0 1 1 1 1 Spindle and kinetochore-associated protein 1 Macoilin PF09726.9 EGE00693.1 - 0.0046 15.6 1.7 0.0056 15.3 1.7 1.1 1 0 0 1 1 1 1 Macoilin family ASD2 PF08687.11 EGE00693.1 - 0.0069 16.0 2.9 0.0092 15.6 2.9 1.2 1 0 0 1 1 1 1 Apx/Shroom domain ASD2 SLATT_4 PF18186.1 EGE00693.1 - 0.0077 15.9 0.3 0.011 15.4 0.3 1.2 1 0 0 1 1 1 1 SMODS and SLOG-associating 2TM effector domain family 4 bZIP_Maf PF03131.17 EGE00693.1 - 0.0089 16.5 10.5 0.0089 16.5 10.5 1.4 1 1 0 1 1 1 1 bZIP Maf transcription factor HALZ PF02183.18 EGE00693.1 - 0.072 13.3 2.1 0.13 12.5 2.1 1.5 1 0 0 1 1 1 0 Homeobox associated leucine zipper Q_salvage PF10343.9 EGE00693.1 - 0.081 12.5 0.7 0.11 12.1 0.7 1.1 1 0 0 1 1 1 0 Potential Queuosine, Q, salvage protein family GAS PF13851.6 EGE00693.1 - 0.081 12.3 6.4 0.1 11.9 6.4 1.1 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding CLZ PF16526.5 EGE00693.1 - 0.11 12.9 3.5 0.25 11.7 3.5 1.6 1 1 0 1 1 1 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels HAUS5 PF14817.6 EGE00693.1 - 0.12 11.1 7.1 0.15 10.8 7.1 1.0 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 5 DUF948 PF06103.11 EGE00693.1 - 0.15 12.3 0.2 0.23 11.7 0.2 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) GvpL_GvpF PF06386.11 EGE00693.1 - 0.2 11.5 5.0 0.35 10.8 5.0 1.4 1 1 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF Csm1_N PF18504.1 EGE00693.1 - 0.32 11.4 5.7 0.7 10.3 1.7 2.2 1 1 1 2 2 2 0 Csm1 N-terminal domain EMP24_GP25L PF01105.24 EGE00693.1 - 0.44 10.5 2.4 0.57 10.1 2.4 1.2 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD DUF349 PF03993.12 EGE00693.1 - 0.63 10.4 4.1 0.95 9.8 4.1 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF349) SURF2 PF05477.11 EGE00695.1 - 0.38 10.4 13.2 0.49 10.0 13.2 1.1 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) eIF-3_zeta PF05091.12 EGE00695.1 - 1.3 7.9 9.8 1.5 7.8 9.8 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) CDC45 PF02724.14 EGE00695.1 - 2.2 6.5 17.7 2.5 6.3 17.7 1.0 1 0 0 1 1 1 0 CDC45-like protein DUF4407 PF14362.6 EGE00695.1 - 5.5 6.2 6.5 6.7 6.0 6.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) RRN3 PF05327.11 EGE00695.1 - 7.2 5.0 6.2 8.5 4.8 6.2 1.0 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Presenilin PF01080.17 EGE00696.1 - 0.044 12.5 5.3 0.044 12.6 5.3 1.0 1 0 0 1 1 1 0 Presenilin SpoIIP PF07454.11 EGE00696.1 - 0.054 12.9 5.9 0.054 12.9 5.9 1.0 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) CENP-N PF05238.13 EGE00696.1 - 0.088 12.1 6.7 0.1 11.9 6.7 1.0 1 0 0 1 1 1 0 Kinetochore protein CHL4 like DDHD PF02862.17 EGE00696.1 - 0.1 12.7 3.8 0.1 12.7 3.8 1.1 1 0 0 1 1 1 0 DDHD domain Eapp_C PF10238.9 EGE00696.1 - 0.12 12.4 7.5 0.14 12.2 7.5 1.2 1 0 0 1 1 1 0 E2F-associated phosphoprotein Connexin PF00029.19 EGE00696.1 - 0.19 11.5 7.7 0.21 11.3 7.7 1.1 1 0 0 1 1 1 0 Connexin Sec62 PF03839.16 EGE00696.1 - 0.32 10.5 7.8 0.42 10.1 7.8 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 EIF4E-T PF10477.9 EGE00696.1 - 0.37 9.6 14.2 0.4 9.5 14.2 1.0 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E CDC45 PF02724.14 EGE00696.1 - 0.38 9.0 11.6 0.39 9.0 11.6 1.0 1 0 0 1 1 1 0 CDC45-like protein DUF4770 PF15994.5 EGE00696.1 - 0.47 10.7 8.3 0.55 10.5 8.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) Peptidase_U57 PF05582.12 EGE00696.1 - 0.49 9.6 5.9 0.61 9.3 5.9 1.1 1 0 0 1 1 1 0 YabG peptidase U57 RNA_polI_A34 PF08208.11 EGE00696.1 - 0.63 10.1 24.3 0.8 9.8 24.3 1.1 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 O-antigen_lig PF13425.6 EGE00696.1 - 0.66 8.7 2.8 0.77 8.5 2.8 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Zip PF02535.22 EGE00696.1 - 0.79 8.9 1.9 0.78 8.9 1.9 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter DUF3464 PF11947.8 EGE00696.1 - 0.83 9.4 11.1 1.1 9.0 11.1 1.3 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 Neur_chan_memb PF02932.16 EGE00696.1 - 0.99 9.4 3.6 1 9.4 3.6 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region MDM10 PF12519.8 EGE00696.1 - 1.1 8.1 5.8 1.3 7.8 5.8 1.0 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 MAJIN PF15077.6 EGE00696.1 - 1.2 8.8 9.4 1.7 8.4 9.4 1.2 1 0 0 1 1 1 0 Membrane-anchored junction protein EIIBC-GUT_N PF03612.14 EGE00696.1 - 1.3 8.8 7.8 1.7 8.3 7.8 1.2 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Pannexin_like PF12534.8 EGE00696.1 - 1.5 7.9 5.0 1.7 7.6 5.0 1.1 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 FAM176 PF14851.6 EGE00696.1 - 1.8 8.2 5.3 2 8.1 5.3 1.2 1 0 0 1 1 1 0 FAM176 family DUF4407 PF14362.6 EGE00696.1 - 2 7.7 4.8 2 7.7 4.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Spt20 PF12090.8 EGE00696.1 - 2.2 7.8 16.2 2.8 7.5 16.2 1.0 1 0 0 1 1 1 0 Spt20 family DUF2828 PF11443.8 EGE00696.1 - 2.3 6.2 12.4 2.8 5.9 12.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) RNA_pol_Rpc4 PF05132.14 EGE00696.1 - 2.4 8.6 12.5 3.2 8.2 12.5 1.1 1 0 0 1 1 1 0 RNA polymerase III RPC4 OATP PF03137.20 EGE00696.1 - 2.5 6.3 5.7 2.7 6.1 5.7 1.0 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family SRP-alpha_N PF04086.13 EGE00696.1 - 2.7 7.9 17.9 3.3 7.5 17.9 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal DUF4337 PF14235.6 EGE00696.1 - 3.2 7.8 6.5 4.2 7.5 6.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) MAP17 PF15807.5 EGE00696.1 - 3.5 7.9 12.9 5.6 7.2 12.9 1.3 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 Tim54 PF11711.8 EGE00696.1 - 4 6.1 13.3 5.1 5.8 13.3 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 RR_TM4-6 PF06459.12 EGE00696.1 - 4.1 7.2 14.4 5.1 6.8 14.4 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 ANAPC15 PF15243.6 EGE00696.1 - 4.3 7.8 9.9 6.7 7.2 9.9 1.2 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 15 MCM_bind PF09739.9 EGE00696.1 - 5.2 5.4 10.4 6.2 5.1 10.4 1.0 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor CLN3 PF02487.17 EGE00696.1 - 5.6 5.9 5.7 6.7 5.6 5.7 1.0 1 0 0 1 1 1 0 CLN3 protein TIMELESS PF04821.14 EGE00696.1 - 6.6 5.9 12.8 8.9 5.5 12.8 1.1 1 0 0 1 1 1 0 Timeless protein DUF3408 PF11888.8 EGE00696.1 - 7.2 6.8 15.2 11 6.2 15.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) AIF_C PF14721.6 EGE00696.1 - 7.5 6.9 8.5 10 6.5 8.5 1.2 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term G-alpha PF00503.20 EGE00697.1 - 2.1e-108 362.7 0.0 2.4e-108 362.5 0.0 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 EGE00697.1 - 1.6e-13 50.5 1.3 5.6e-09 35.7 0.0 2.7 3 0 0 3 3 3 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EGE00697.1 - 6.5e-07 28.9 0.1 0.00089 18.7 0.0 2.3 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region BsuBI_PstI_RE PF06616.11 EGE00697.1 - 0.0014 17.9 0.1 0.0025 17.1 0.1 1.3 1 0 0 1 1 1 1 BsuBI/PstI restriction endonuclease domain Roc PF08477.13 EGE00697.1 - 0.0039 17.4 0.2 1.4 9.2 0.0 2.8 3 0 0 3 3 3 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 EGE00697.1 - 0.013 15.5 0.0 4.2 7.5 0.0 2.5 2 0 0 2 2 2 0 50S ribosome-binding GTPase TniB PF05621.11 EGE00697.1 - 0.016 14.6 0.0 0.034 13.5 0.0 1.5 1 0 0 1 1 1 0 Bacterial TniB protein AAA_29 PF13555.6 EGE00697.1 - 0.084 12.6 0.0 0.17 11.7 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain FtsK_SpoIIIE PF01580.18 EGE00697.1 - 0.09 12.1 0.1 0.36 10.2 0.0 1.8 2 0 0 2 2 2 0 FtsK/SpoIIIE family DUF1713 PF08213.11 EGE00698.1 - 1.2e-10 41.1 22.0 1.2e-10 41.1 22.0 1.8 2 0 0 2 2 2 1 Mitochondrial domain of unknown function (DUF1713) Pet20 PF08692.10 EGE00698.1 - 0.009 16.7 0.5 0.025 15.3 0.0 2.1 2 0 0 2 2 2 1 Mitochondrial protein Pet20 ATP-synt_C PF00137.21 EGE00699.1 - 2.4e-36 123.9 34.2 5.1e-22 78.0 15.8 2.1 2 0 0 2 2 2 2 ATP synthase subunit C p450 PF00067.22 EGE00701.1 - 6.1e-57 193.4 0.0 1.1e-55 189.2 0.0 2.0 1 1 0 1 1 1 1 Cytochrome P450 Pmp3 PF01679.17 EGE00702.1 - 5.6e-23 80.9 5.8 6.3e-23 80.7 5.8 1.0 1 0 0 1 1 1 1 Proteolipid membrane potential modulator APH PF01636.23 EGE00705.1 - 5.1e-12 46.2 0.0 1.7e-11 44.5 0.0 1.8 2 0 0 2 2 2 1 Phosphotransferase enzyme family DUF1679 PF07914.11 EGE00705.1 - 0.0016 17.4 0.0 0.011 14.7 0.0 2.3 2 1 0 2 2 2 1 Protein of unknown function (DUF1679) EcKinase PF02958.20 EGE00705.1 - 0.047 13.0 0.0 0.077 12.3 0.0 1.3 1 0 0 1 1 1 0 Ecdysteroid kinase Choline_kinase PF01633.20 EGE00705.1 - 0.075 12.6 0.0 0.16 11.5 0.0 1.5 1 0 0 1 1 1 0 Choline/ethanolamine kinase Macro PF01661.21 EGE00707.1 - 3.4e-12 46.5 0.0 3.7e-06 27.0 0.0 2.5 2 1 0 2 2 2 2 Macro domain CENP-X PF09415.10 EGE00708.1 - 1.7e-23 82.7 0.4 3.5e-23 81.7 0.4 1.5 1 0 0 1 1 1 1 CENP-S associating Centromere protein X Paramyxo_ncap PF00973.19 EGE00708.1 - 1 8.2 4.7 1.4 7.7 4.7 1.2 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein DDHD PF02862.17 EGE00708.1 - 5.2 7.2 7.9 13 5.8 7.9 1.7 1 1 0 1 1 1 0 DDHD domain Mis12 PF05859.12 EGE00710.1 - 1.2e-47 161.3 0.0 2.1e-47 160.6 0.0 1.4 1 0 0 1 1 1 1 Mis12 protein ATG16 PF08614.11 EGE00710.1 - 0.028 14.6 1.5 0.16 12.1 0.2 2.1 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) MitoNEET_N PF10660.9 EGE00710.1 - 0.094 12.7 0.0 0.21 11.7 0.0 1.5 1 0 0 1 1 1 0 Iron-containing outer mitochondrial membrane protein N-terminus Trans_reg_C PF00486.28 EGE00711.1 - 0.014 15.4 0.8 0.056 13.5 0.1 2.0 1 1 0 2 2 2 0 Transcriptional regulatory protein, C terminal SLATT_4 PF18186.1 EGE00712.1 - 0.096 12.3 0.1 0.3 10.7 0.0 1.8 1 1 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain family 4 DUF2371 PF10177.9 EGE00712.1 - 0.88 9.7 3.1 4.3 7.5 0.1 2.7 1 1 1 2 2 2 0 Uncharacterised conserved protein (DUF2371) DUF4131 PF13567.6 EGE00712.1 - 5.5 6.6 5.8 1.7 8.2 0.6 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4131) BCNT PF07572.12 EGE00713.1 - 1.4e-26 92.3 0.2 3.8e-26 91.0 0.2 1.7 1 0 0 1 1 1 1 Bucentaur or craniofacial development Pheromone PF08015.11 EGE00713.1 - 1.6 9.8 4.2 4.5 8.4 3.2 2.4 1 1 0 1 1 1 0 Fungal mating-type pheromone Acetyltransf_3 PF13302.7 EGE00714.1 - 6.4e-31 107.9 0.0 7.7e-31 107.6 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 EGE00714.1 - 0.0064 16.2 0.0 0.012 15.3 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EGE00714.1 - 0.016 15.5 0.0 0.018 15.2 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family Methyltransf_3 PF01596.17 EGE00715.1 - 1.2e-30 106.3 0.0 1.9e-30 105.6 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase PCMT PF01135.19 EGE00715.1 - 5.6e-11 42.6 0.0 7.9e-11 42.1 0.0 1.1 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_24 PF13578.6 EGE00715.1 - 3.3e-10 40.9 0.0 8.4e-10 39.6 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EGE00715.1 - 1.9e-08 34.2 0.0 2.6e-08 33.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EGE00715.1 - 3.5e-07 30.8 0.0 7.4e-07 29.8 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EGE00715.1 - 0.00038 19.9 0.0 0.0005 19.5 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_11 PF08241.12 EGE00715.1 - 0.0015 19.2 0.0 0.0065 17.1 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 EGE00715.1 - 0.0024 17.3 0.0 0.0048 16.4 0.0 1.4 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_12 PF08242.12 EGE00715.1 - 0.019 15.7 0.0 0.043 14.6 0.0 1.7 1 1 0 1 1 1 0 Methyltransferase domain GCD14 PF08704.10 EGE00715.1 - 0.038 13.7 0.0 0.051 13.2 0.0 1.2 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit Response_reg PF00072.24 EGE00715.1 - 0.16 12.1 0.0 5.8 7.1 0.0 2.2 2 0 0 2 2 2 0 Response regulator receiver domain ADP_ribosyl_GH PF03747.14 EGE00716.1 - 0.26 11.0 6.0 0.14 11.9 2.5 1.9 1 1 1 2 2 2 0 ADP-ribosylglycohydrolase Rieske_3 PF18465.1 EGE00716.1 - 9.1 6.6 8.2 0.49 10.7 0.9 2.4 2 1 0 2 2 2 0 Rieske 3Fe-4S Spt20 PF12090.8 EGE00717.1 - 1.2e-13 51.3 0.9 1.2e-13 51.3 0.9 3.7 2 1 0 2 2 2 1 Spt20 family Med15 PF09606.10 EGE00717.1 - 0.00069 18.4 57.7 0.00069 18.4 57.7 1.7 2 0 0 2 2 2 1 ARC105 or Med15 subunit of Mediator complex non-fungal GREB1 PF15782.5 EGE00717.1 - 0.1 9.7 27.5 0.16 9.1 27.5 1.2 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DUF572 PF04502.13 EGE00717.1 - 2 8.0 22.4 3.9 7.0 22.4 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF572) Draxin PF15550.6 EGE00717.1 - 2.2 8.1 17.9 4.3 7.1 17.9 1.5 1 0 0 1 1 1 0 Draxin Red1 PF07964.11 EGE00717.1 - 5.2 5.2 16.9 8.1 4.6 16.9 1.2 1 0 0 1 1 1 0 Rec10 / Red1 AKAP28 PF14469.6 EGE00718.1 - 0.061 13.1 0.3 0.12 12.1 0.3 1.5 1 0 0 1 1 1 0 28 kDa A-kinase anchor Serglycin PF04360.12 EGE00719.1 - 2.1 8.3 11.3 0.22 11.5 5.5 2.2 2 0 0 2 2 2 0 Serglycin Chordopox_A33R PF05966.12 EGE00721.1 - 0.19 11.0 0.0 0.26 10.5 0.0 1.2 1 0 0 1 1 1 0 Chordopoxvirus A33R protein TetR_C_19 PF17924.1 EGE00722.1 - 0.075 13.6 0.4 3.4 8.3 0.2 2.1 1 1 1 2 2 2 0 Tetracyclin repressor-like, C-terminal domain Hexapep PF00132.24 EGE00724.1 - 2.2e-06 27.1 2.9 0.023 14.4 0.3 3.7 1 1 2 3 3 3 3 Bacterial transferase hexapeptide (six repeats) Fucokinase PF07959.12 EGE00724.1 - 5.7e-06 25.5 0.1 9.7e-06 24.8 0.1 1.3 1 0 0 1 1 1 1 L-fucokinase NTP_transferase PF00483.23 EGE00724.1 - 0.0006 19.5 0.0 0.00097 18.8 0.0 1.2 1 0 0 1 1 1 1 Nucleotidyl transferase DUF4954 PF16314.5 EGE00724.1 - 0.019 13.2 0.2 0.026 12.7 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4954) NTP_transf_3 PF12804.7 EGE00724.1 - 0.039 14.3 0.0 0.083 13.2 0.0 1.6 1 0 0 1 1 1 0 MobA-like NTP transferase domain MMPL PF03176.15 EGE00725.1 - 0.096 11.6 2.7 2 7.3 0.2 2.2 2 0 0 2 2 2 0 MMPL family Mucin PF01456.17 EGE00728.1 - 2.1 8.4 11.3 2.3 8.2 11.1 1.2 1 1 0 1 1 1 0 Mucin-like glycoprotein Gemini_V2 PF01524.17 EGE00729.1 - 0.15 12.3 0.0 0.36 11.1 0.0 1.6 1 0 0 1 1 1 0 Geminivirus V2 protein zf-C4H2 PF10146.9 EGE00730.1 - 3.3 8.0 11.1 4 7.7 11.1 1.1 1 0 0 1 1 1 0 Zinc finger-containing protein ELO PF01151.18 EGE00731.1 - 6.6e-39 133.9 2.1 8.4e-39 133.6 2.1 1.1 1 0 0 1 1 1 1 GNS1/SUR4 family Nuc_deoxyri_tr2 PF15891.5 EGE00731.1 - 0.0025 18.1 0.7 0.0047 17.2 0.7 1.5 1 0 0 1 1 1 1 Nucleoside 2-deoxyribosyltransferase like SID-1_RNA_chan PF13965.6 EGE00731.1 - 1.1 7.6 3.2 0.67 8.3 0.3 1.8 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 DUF2072 PF09845.9 EGE00731.1 - 1.3 9.3 8.0 4.4 7.6 8.0 1.9 1 1 0 1 1 1 0 Zn-ribbon containing protein Fungal_trans PF04082.18 EGE00734.1 - 6.7e-21 74.5 0.0 1.6e-20 73.3 0.0 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EGE00734.1 - 2.2e-09 37.3 11.0 3.7e-09 36.5 11.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain TFIIA PF03153.13 EGE00734.1 - 2.8e-06 27.6 25.3 0.00028 21.0 6.7 2.2 2 0 0 2 2 2 2 Transcription factor IIA, alpha/beta subunit TF_Zn_Ribbon PF08271.12 EGE00734.1 - 0.091 12.3 0.1 0.091 12.3 0.1 2.3 2 0 0 2 2 2 0 TFIIB zinc-binding MMR1 PF08505.10 EGE00734.1 - 0.61 10.3 19.3 0.32 11.2 9.8 2.4 2 0 0 2 2 2 0 Mitochondrial Myo2 receptor-related protein DUF1180 PF06679.12 EGE00734.1 - 0.95 9.9 9.9 1.9 8.9 2.8 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1180) CCDC53 PF10152.9 EGE00734.1 - 1.1 9.7 15.3 0.22 11.9 2.7 2.6 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex Macoilin PF09726.9 EGE00734.1 - 2.7 6.4 9.3 4.5 5.7 9.3 1.3 1 0 0 1 1 1 0 Macoilin family Neur_chan_memb PF02932.16 EGE00734.1 - 3.8 7.5 15.6 2.4 8.1 7.8 2.3 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Aminotran_1_2 PF00155.21 EGE00735.1 - 7.2e-18 64.9 0.0 1e-17 64.4 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_MocR PF12897.7 EGE00735.1 - 0.0097 14.7 0.0 0.044 12.6 0.0 1.8 1 1 0 1 1 1 1 Alanine-glyoxylate amino-transferase Pkinase PF00069.25 EGE00736.1 - 8.4e-54 182.7 0.0 1.1e-53 182.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGE00736.1 - 6.7e-40 137.0 0.0 1.1e-39 136.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EGE00736.1 - 0.0012 17.8 0.0 0.0022 16.9 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EGE00736.1 - 0.0034 16.8 0.0 0.0089 15.4 0.0 1.6 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EGE00736.1 - 0.0051 16.2 0.0 0.0085 15.4 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 EGE00736.1 - 0.0097 14.9 1.5 0.02 13.9 0.0 2.1 3 0 0 3 3 3 1 Haspin like kinase domain APH PF01636.23 EGE00736.1 - 0.035 14.0 0.1 0.17 11.8 0.0 2.1 2 0 0 2 2 2 0 Phosphotransferase enzyme family Pkinase PF00069.25 EGE00738.1 - 1e-68 231.6 0.0 1.5e-68 231.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EGE00738.1 - 6.3e-35 120.7 0.0 1.4e-34 119.6 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 EGE00738.1 - 9.8e-06 25.1 0.0 1.7e-05 24.3 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 EGE00738.1 - 0.003 16.9 0.0 0.0065 15.8 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family TetR_C_27 PF17935.1 EGE00738.1 - 0.059 13.4 0.0 0.52 10.4 0.0 2.2 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain YrbL-PhoP_reg PF10707.9 EGE00738.1 - 0.094 12.2 1.4 0.28 10.7 0.0 2.4 4 0 0 4 4 4 0 PhoP regulatory network protein YrbL Methyltransf_8 PF05148.15 EGE00739.1 - 1.2e-57 195.3 0.5 4.9e-54 183.5 0.0 2.8 3 0 0 3 3 3 2 Hypothetical methyltransferase Methyltransf_11 PF08241.12 EGE00739.1 - 1.9e-06 28.5 0.0 9.7e-06 26.2 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EGE00739.1 - 2.7e-05 24.8 0.0 0.0018 19.0 0.0 2.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 EGE00739.1 - 0.019 14.9 1.0 0.055 13.5 0.0 2.2 3 0 0 3 3 3 0 Methyltransferase domain Methyltransf_31 PF13847.6 EGE00739.1 - 0.078 12.8 0.0 4.7 7.0 0.0 2.3 1 1 1 2 2 2 0 Methyltransferase domain Proteasome PF00227.26 EGE00740.1 - 1.2e-56 191.2 0.1 1.6e-56 190.8 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EGE00740.1 - 1.4e-12 47.0 0.2 3.6e-12 45.7 0.0 1.8 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature GCP_N_terminal PF17681.1 EGE00741.1 - 3.4e-64 217.4 0.0 5.9e-64 216.6 0.0 1.4 1 0 0 1 1 1 1 Gamma tubulin complex component N-terminal GCP_C_terminal PF04130.13 EGE00741.1 - 3.7e-60 204.0 4.5 7.1e-60 203.1 4.5 1.4 1 0 0 1 1 1 1 Gamma tubulin complex component C-terminal KH_8 PF17903.1 EGE00742.1 - 6.9e-30 103.0 0.0 1.7e-29 101.7 0.0 1.7 1 0 0 1 1 1 1 Krr1 KH1 domain Methyltransf_25 PF13649.6 EGE00743.1 - 1.8e-13 51.0 0.0 5.8e-13 49.4 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EGE00743.1 - 2.3e-13 50.3 0.0 3.2e-13 49.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EGE00743.1 - 6.2e-13 49.2 0.0 1.2e-12 48.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EGE00743.1 - 3.9e-09 37.2 0.0 1.1e-08 35.8 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EGE00743.1 - 2.4e-07 30.7 0.0 2.5e-06 27.4 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 EGE00743.1 - 0.00078 19.0 0.0 0.0015 18.0 0.0 1.4 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_2 PF00891.18 EGE00743.1 - 0.001 18.4 0.0 0.0019 17.5 0.0 1.6 1 1 0 1 1 1 1 O-methyltransferase domain CMAS PF02353.20 EGE00743.1 - 0.0011 18.3 0.0 0.0061 15.9 0.0 2.1 2 1 0 2 2 2 1 Mycolic acid cyclopropane synthetase MTS PF05175.14 EGE00743.1 - 0.045 13.3 0.0 0.082 12.4 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain Ubie_methyltran PF01209.18 EGE00743.1 - 0.066 12.5 0.0 0.34 10.2 0.0 2.0 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family adh_short PF00106.25 EGE00744.1 - 5.2e-40 137.0 0.0 6.8e-40 136.6 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EGE00744.1 - 5.5e-23 81.7 0.0 7.3e-23 81.3 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EGE00744.1 - 1.6e-06 28.2 0.0 2.4e-06 27.6 0.0 1.2 1 0 0 1 1 1 1 KR domain GDP_Man_Dehyd PF16363.5 EGE00744.1 - 0.00045 19.7 0.0 0.00058 19.3 0.0 1.1 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 EGE00744.1 - 0.00062 19.0 0.1 0.00097 18.4 0.1 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Epimerase PF01370.21 EGE00744.1 - 0.046 13.2 0.0 0.061 12.8 0.0 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family 3HCDH_N PF02737.18 EGE00744.1 - 0.11 12.3 0.1 0.19 11.6 0.1 1.2 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Erg28 PF03694.13 EGE00745.1 - 1.6e-42 144.3 3.6 2e-42 144.0 3.6 1.1 1 0 0 1 1 1 1 Erg28 like protein GalP_UDP_transf PF01087.22 EGE00746.1 - 5.9e-69 232.2 0.1 8e-68 228.5 0.1 2.1 2 0 0 2 2 2 1 Galactose-1-phosphate uridyl transferase, N-terminal domain GalP_UDP_tr_C PF02744.17 EGE00746.1 - 1.9e-59 200.1 0.2 4.6e-59 198.9 0.1 1.6 2 0 0 2 2 2 1 Galactose-1-phosphate uridyl transferase, C-terminal domain DUF4921 PF16268.5 EGE00746.1 - 0.0031 16.4 0.0 0.15 10.9 0.0 2.3 2 1 0 2 2 2 2 Domain of unknown function (DUF4921) DcpS_C PF11969.8 EGE00746.1 - 0.14 12.6 0.0 0.43 11.1 0.0 1.8 1 0 0 1 1 1 0 Scavenger mRNA decapping enzyme C-term binding WG_beta_rep PF14903.6 EGE00746.1 - 0.19 12.0 0.1 0.5 10.7 0.1 1.7 1 0 0 1 1 1 0 WG containing repeat eIF3_subunit PF08597.10 EGE00748.1 - 0.035 14.0 0.1 0.035 14.0 0.1 2.3 3 0 0 3 3 3 0 Translation initiation factor eIF3 subunit NAPRTase PF04095.16 EGE00749.1 - 4.6e-56 190.1 0.1 2.1e-28 99.6 0.2 2.1 2 0 0 2 2 2 2 Nicotinate phosphoribosyltransferase (NAPRTase) family NAPRTase_N PF17767.1 EGE00749.1 - 9e-35 119.8 0.2 2e-34 118.7 0.2 1.6 1 0 0 1 1 1 1 Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain Syntaxin PF00804.25 EGE00751.1 - 9.4e-16 58.1 12.2 9.4e-16 58.1 12.2 2.0 2 1 0 2 2 2 1 Syntaxin SNARE PF05739.19 EGE00751.1 - 4e-08 33.1 3.8 4e-08 33.1 3.8 3.0 2 1 1 3 3 3 1 SNARE domain Use1 PF09753.9 EGE00751.1 - 6.5e-06 26.1 5.1 9e-06 25.6 5.1 1.1 1 0 0 1 1 1 1 Membrane fusion protein Use1 MCU PF04678.13 EGE00751.1 - 0.0032 17.6 5.1 0.0052 16.9 1.1 2.3 1 1 1 2 2 2 1 Mitochondrial calcium uniporter Spectrin PF00435.21 EGE00751.1 - 0.0037 17.7 5.0 1.7 9.1 0.0 3.1 2 2 1 3 3 3 2 Spectrin repeat COG2 PF06148.11 EGE00751.1 - 0.0042 17.2 4.6 0.0091 16.1 0.2 2.6 2 1 0 2 2 2 1 COG (conserved oligomeric Golgi) complex component, COG2 TRP PF06011.12 EGE00751.1 - 0.019 13.7 0.0 0.023 13.4 0.0 1.1 1 0 0 1 1 1 0 Transient receptor potential (TRP) ion channel DUF2207 PF09972.9 EGE00751.1 - 0.024 13.4 0.0 0.04 12.7 0.0 1.3 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) ETRAMP PF09716.10 EGE00751.1 - 0.059 13.4 0.0 0.11 12.6 0.0 1.3 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) SP_C-Propep PF08999.10 EGE00751.1 - 0.068 13.0 2.5 0.12 12.2 2.5 1.3 1 0 0 1 1 1 0 Surfactant protein C, N terminal propeptide Orf78 PF06024.12 EGE00751.1 - 0.082 13.2 0.4 0.082 13.2 0.4 2.2 2 1 0 2 2 2 0 Orf78 (ac78) SCAB-ABD PF16711.5 EGE00751.1 - 0.093 12.6 0.3 0.093 12.6 0.3 2.0 3 0 0 3 3 2 0 Actin-binding domain of plant-specific actin-binding protein DUF5345 PF17280.2 EGE00751.1 - 0.097 12.7 0.2 0.097 12.7 0.2 2.1 2 0 0 2 2 1 0 Family of unknown function (DUF5345) MT0933_antitox PF14013.6 EGE00751.1 - 0.12 12.7 0.7 0.5 10.7 0.2 2.3 2 0 0 2 2 2 0 MT0933-like antitoxin protein Baculo_F PF12259.8 EGE00751.1 - 0.12 10.8 12.0 0.16 10.4 0.0 2.5 1 1 2 3 3 3 0 Baculovirus F protein Gp58 PF07902.11 EGE00751.1 - 0.14 10.5 7.9 0.16 10.2 7.9 1.1 1 0 0 1 1 1 0 gp58-like protein PBP1_TM PF14812.6 EGE00751.1 - 0.14 12.6 0.1 0.14 12.6 0.1 2.6 2 1 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Activator-TraM PF11657.8 EGE00751.1 - 0.28 11.0 6.7 0.29 11.0 1.5 2.2 1 1 1 2 2 2 0 Transcriptional activator TraM Pox_EPC_I2-L1 PF12575.8 EGE00751.1 - 0.29 11.4 1.9 0.75 10.1 1.9 1.6 1 0 0 1 1 1 0 Poxvirus entry protein complex L1 and I2 Fusion_F0 PF13044.6 EGE00751.1 - 0.29 9.7 1.9 0.5 9.0 1.9 1.3 1 0 0 1 1 1 0 Fusion glycoprotein F0, Isavirus Baculo_11_kDa PF06143.11 EGE00751.1 - 0.32 10.6 5.4 1.2 8.8 5.4 2.1 1 0 0 1 1 1 0 Baculovirus 11 kDa family ISG65-75 PF11727.8 EGE00751.1 - 2.3 7.4 5.9 10 5.3 2.6 2.2 2 0 0 2 2 2 0 Invariant surface glycoprotein DUF4407 PF14362.6 EGE00751.1 - 2.7 7.3 11.9 8.4 5.6 11.9 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Fib_alpha PF08702.10 EGE00751.1 - 2.9 8.0 10.1 6.5 6.9 0.5 2.7 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Tam41_Mmp37 PF09139.11 EGE00751.1 - 3.2 7.1 7.9 1.4 8.3 2.0 2.1 1 1 1 2 2 2 0 Phosphatidate cytidylyltransferase, mitochondrial TSC22 PF01166.18 EGE00751.1 - 3.3 8.1 5.9 1.3 9.4 0.2 2.8 3 0 0 3 3 2 0 TSC-22/dip/bun family HisKA_3 PF07730.13 EGE00751.1 - 5 7.7 7.4 4 8.0 0.2 3.6 2 1 2 4 4 4 0 Histidine kinase zf-C4H2 PF10146.9 EGE00751.1 - 5.5 7.2 11.0 9.7 6.4 0.7 2.2 1 1 1 2 2 2 0 Zinc finger-containing protein BolA PF01722.18 EGE00752.1 - 3.6e-18 65.6 0.0 4.4e-18 65.3 0.0 1.1 1 0 0 1 1 1 1 BolA-like protein RPA_C PF08784.11 EGE00752.1 - 0.014 16.0 0.0 0.015 15.9 0.0 1.1 1 0 0 1 1 1 0 Replication protein A C terminal Cofilin_ADF PF00241.20 EGE00752.1 - 0.096 12.5 0.0 0.1 12.4 0.0 1.1 1 0 0 1 1 1 0 Cofilin/tropomyosin-type actin-binding protein Ribosomal_S5 PF00333.20 EGE00755.1 - 1.3e-27 95.6 2.1 9.2e-27 92.8 1.0 2.5 2 0 0 2 2 2 1 Ribosomal protein S5, N-terminal domain Ribosomal_S5_C PF03719.15 EGE00755.1 - 9.9e-22 76.2 0.0 1.6e-21 75.5 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain FoP_duplication PF13865.6 EGE00755.1 - 2.6 8.6 11.0 6.2 7.4 11.0 1.5 1 0 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 Bac_rhodopsin PF01036.18 EGE00757.1 - 2.2e-38 132.1 17.9 2.6e-38 131.8 17.9 1.0 1 0 0 1 1 1 1 Bacteriorhodopsin-like protein Phage_holin_3_6 PF07332.11 EGE00757.1 - 0.0012 18.9 9.8 0.066 13.3 1.7 3.1 2 1 1 3 3 3 2 Putative Actinobacterial Holin-X, holin superfamily III DUF1345 PF07077.11 EGE00757.1 - 0.0033 17.2 8.0 0.0097 15.6 0.5 2.4 2 1 0 2 2 2 2 Protein of unknown function (DUF1345) DUF3810 PF12725.7 EGE00757.1 - 0.13 11.5 13.6 0.12 11.7 1.2 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF3810) DUF2391 PF09622.10 EGE00757.1 - 0.14 11.4 5.6 0.071 12.4 1.8 2.0 1 1 1 2 2 2 0 Putative integral membrane protein (DUF2391) Glycos_transf_4 PF00953.21 EGE00757.1 - 0.24 11.4 13.1 0.26 11.2 9.0 2.5 1 1 1 2 2 2 0 Glycosyl transferase family 4 DUF3938 PF13074.6 EGE00757.1 - 1.6 9.0 13.2 0.086 13.1 2.6 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF3938) tRNA-synt_1 PF00133.22 EGE00758.1 - 1.5e-162 542.0 0.0 1.9e-162 541.6 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 EGE00758.1 - 2.6e-21 76.2 0.4 5.4e-21 75.1 0.4 1.5 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 EGE00758.1 - 1.5e-20 73.3 0.1 2.1e-13 49.8 0.0 4.2 3 1 0 3 3 3 3 tRNA synthetases class I (M) tRNA-synt_1_2 PF13603.6 EGE00758.1 - 0.052 13.1 0.0 0.12 11.8 0.0 1.6 1 0 0 1 1 1 0 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1e PF01406.19 EGE00758.1 - 0.066 12.5 0.0 3.3 7.0 0.0 2.2 2 0 0 2 2 2 0 tRNA synthetases class I (C) catalytic domain zf-FPG_IleRS PF06827.14 EGE00758.1 - 9.5 6.2 8.7 35 4.4 8.7 1.9 1 1 0 1 1 1 0 Zinc finger found in FPG and IleRS UPF0183 PF03676.14 EGE00759.1 - 9.1e-64 216.2 0.0 1.3e-40 139.9 0.0 2.6 2 1 0 2 2 2 2 Uncharacterised protein family (UPF0183) Kinesin PF00225.23 EGE00760.1 - 6.9e-107 357.2 0.4 2.1e-106 355.7 0.4 1.9 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EGE00760.1 - 6e-26 91.2 0.0 4.3e-25 88.4 0.0 2.6 2 0 0 2 2 2 1 Microtubule binding Microtub_bind PF13931.6 EGE00760.1 - 1.4e-07 31.9 1.2 1.4e-07 31.9 1.2 5.1 4 1 1 5 5 5 1 Kinesin-associated microtubule-binding zf-ANAPC11 PF12861.7 EGE00761.1 - 2.8e-44 149.1 9.5 5e-44 148.3 9.5 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.7 EGE00761.1 - 6.6e-21 74.3 9.9 1.4e-20 73.3 9.9 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 EGE00761.1 - 6.1e-07 29.7 13.3 4e-06 27.1 13.3 2.2 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 EGE00761.1 - 0.00072 19.4 9.1 0.0017 18.2 9.1 1.7 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EGE00761.1 - 0.0018 18.3 7.8 0.0072 16.3 7.8 2.1 1 1 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 EGE00761.1 - 0.024 14.5 14.7 0.033 14.0 11.8 2.3 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EGE00761.1 - 0.12 12.6 6.8 0.35 11.1 6.8 1.9 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 EGE00761.1 - 0.13 12.3 12.2 0.38 10.8 12.3 1.9 1 1 0 1 1 1 0 zinc-RING finger domain zf-C3HC4_3 PF13920.6 EGE00761.1 - 0.14 12.0 11.4 0.029 14.2 6.1 2.1 1 1 2 3 3 3 0 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 EGE00761.1 - 0.18 11.4 9.4 0.59 9.8 9.4 1.8 1 1 0 1 1 1 0 Zinc-ribbon, C4HC2 type FANCL_C PF11793.8 EGE00761.1 - 0.34 11.1 11.4 1.5 9.0 11.4 2.2 1 1 0 1 1 1 0 FANCL C-terminal domain zf-RING_4 PF14570.6 EGE00761.1 - 0.72 9.7 10.9 5.6 6.8 8.1 2.5 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain zf-RING_11 PF17123.5 EGE00761.1 - 1.1 9.1 8.1 3.8 7.3 8.1 2.0 1 1 0 1 1 1 0 RING-like zinc finger PHD PF00628.29 EGE00761.1 - 3 7.8 10.2 7.3 6.6 10.2 1.7 1 1 0 1 1 1 0 PHD-finger zf-RING-like PF08746.11 EGE00761.1 - 6 7.3 7.3 19 5.7 7.4 1.8 1 1 0 1 1 1 0 RING-like domain RINGv PF12906.7 EGE00761.1 - 7 6.9 9.2 2.1 8.5 6.1 1.8 2 0 0 2 2 1 0 RING-variant domain Rhodanese PF00581.20 EGE00762.1 - 1e-19 71.0 0.0 4.7e-10 39.9 0.0 2.3 2 0 0 2 2 2 2 Rhodanese-like domain potato_inhibit PF00280.18 EGE00762.1 - 0.1 13.3 0.0 32 5.3 0.0 2.6 2 0 0 2 2 2 0 Potato inhibitor I family PIN_4 PF13638.6 EGE00763.1 - 2.2e-05 24.8 0.1 0.013 15.7 0.0 2.7 2 2 1 3 3 3 2 PIN domain NYN_YacP PF05991.11 EGE00763.1 - 0.12 12.3 0.0 0.25 11.3 0.0 1.4 1 0 0 1 1 1 0 YacP-like NYN domain Metallophos PF00149.28 EGE00765.1 - 5.4e-07 30.3 0.1 8.4e-07 29.7 0.1 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase RPEL PF02755.15 EGE00766.1 - 6.8e-27 92.3 2.1 1.5e-07 30.9 0.1 3.4 3 0 0 3 3 3 3 RPEL repeat Rotamase_3 PF13616.6 EGE00766.1 - 0.011 16.3 0.3 0.048 14.2 0.1 1.9 1 1 1 2 2 2 0 PPIC-type PPIASE domain Translin PF01997.16 EGE00767.1 - 6.4e-61 205.9 0.1 7.9e-61 205.6 0.1 1.1 1 0 0 1 1 1 1 Translin family Hemerythrin PF01814.23 EGE00767.1 - 0.058 14.0 0.0 0.19 12.4 0.0 1.8 2 0 0 2 2 2 0 Hemerythrin HHE cation binding domain NPV_P10 PF05531.12 EGE00767.1 - 0.21 12.1 0.9 8.6 6.9 0.0 2.9 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Mannosyl_trans PF05007.13 EGE00768.1 - 7.2e-79 265.3 10.7 1.1e-78 264.6 10.7 1.3 1 0 0 1 1 1 1 Mannosyltransferase (PIG-M) PIG-U PF06728.13 EGE00768.1 - 8.6e-12 44.8 0.6 8.6e-12 44.8 0.6 2.4 2 1 0 2 2 2 1 GPI transamidase subunit PIG-U GT87 PF09594.10 EGE00768.1 - 7.6e-05 22.5 7.5 7.6e-05 22.5 7.5 2.9 3 1 0 3 3 3 1 Glycosyltransferase family 87 FYRC PF05965.14 EGE00769.1 - 0.14 12.3 0.0 7.5 6.8 0.0 2.5 2 0 0 2 2 2 0 F/Y rich C-terminus Complex1_LYR PF05347.15 EGE00771.1 - 6.4e-19 67.7 4.6 7.2e-19 67.6 4.6 1.0 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 EGE00771.1 - 9.2e-05 23.1 3.0 9.9e-05 23.0 3.0 1.1 1 0 0 1 1 1 1 Complex1_LYR-like Catalase-rel PF06628.12 EGE00771.1 - 0.18 12.0 3.4 1.6 9.0 1.8 2.0 1 1 1 2 2 2 0 Catalase-related immune-responsive Pex14_N PF04695.13 EGE00772.1 - 0.022 15.4 0.6 0.037 14.7 0.6 1.4 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region CPSF100_C PF13299.6 EGE00772.1 - 0.066 13.4 1.3 0.099 12.8 1.3 1.4 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal SAPS PF04499.15 EGE00772.1 - 1.3 7.8 5.0 1.6 7.4 5.0 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein CDC45 PF02724.14 EGE00772.1 - 1.9 6.7 6.2 2.8 6.1 6.2 1.2 1 0 0 1 1 1 0 CDC45-like protein RR_TM4-6 PF06459.12 EGE00772.1 - 9 6.0 10.6 13 5.5 10.6 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 TFIIA PF03153.13 EGE00773.1 - 1.6 8.7 9.4 1.9 8.4 9.4 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Msap1 PF17077.5 EGE00773.1 - 9.3 5.3 10.2 16 4.6 10.2 1.3 1 0 0 1 1 1 0 Mitotic spindle associated protein SHE1 hEGF PF12661.7 EGE00774.1 - 0.44 11.3 7.6 1 10.1 7.6 1.7 1 0 0 1 1 1 0 Human growth factor-like EGF EGF_CA PF07645.15 EGE00774.1 - 1 9.6 5.6 2.2 8.6 5.6 1.5 1 0 0 1 1 1 0 Calcium-binding EGF domain EGF PF00008.27 EGE00774.1 - 1.7 9.0 8.3 3.7 7.9 8.3 1.6 1 0 0 1 1 1 0 EGF-like domain AJAP1_PANP_C PF15298.6 EGE00774.1 - 2.1 8.6 11.0 29 4.8 0.0 2.5 2 0 0 2 2 2 0 AJAP1/PANP C-terminus ATP-sulfurylase PF01747.17 EGE00776.1 - 1.8e-87 292.3 0.0 2.5e-87 291.8 0.0 1.2 1 0 0 1 1 1 1 ATP-sulfurylase APS_kinase PF01583.20 EGE00776.1 - 1.2e-57 194.2 0.0 1.9e-57 193.6 0.0 1.3 1 0 0 1 1 1 1 Adenylylsulphate kinase PUA_2 PF14306.6 EGE00776.1 - 4e-50 169.6 0.0 6.7e-50 168.9 0.0 1.4 1 0 0 1 1 1 1 PUA-like domain PAPS_reduct PF01507.19 EGE00779.1 - 1.2e-42 145.9 0.0 1.7e-42 145.4 0.0 1.2 1 0 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family HAD PF12710.7 EGE00780.1 - 7.3e-23 81.9 0.0 1.1e-22 81.3 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EGE00780.1 - 2.3e-19 70.5 0.6 3.1e-19 70.1 0.6 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 EGE00780.1 - 8.5e-08 32.2 0.1 1.7e-06 27.9 0.0 2.6 3 0 0 3 3 3 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 EGE00780.1 - 0.00019 21.6 0.1 0.0029 17.7 0.1 2.7 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Put_Phosphatase PF06888.12 EGE00780.1 - 0.0032 16.9 0.0 0.079 12.3 0.0 2.1 2 0 0 2 2 2 1 Putative Phosphatase DUF705 PF05152.12 EGE00780.1 - 0.051 13.0 0.1 0.076 12.5 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF705) S6PP PF05116.13 EGE00780.1 - 0.15 11.6 0.1 0.43 10.1 0.0 1.7 2 0 0 2 2 2 0 Sucrose-6F-phosphate phosphohydrolase LIAS_N PF16881.5 EGE00781.1 - 2.9e-26 92.0 0.0 6.9e-26 90.8 0.0 1.7 1 0 0 1 1 1 1 N-terminal domain of lipoyl synthase of Radical_SAM family Radical_SAM PF04055.21 EGE00781.1 - 2.3e-13 50.9 0.0 3.8e-13 50.1 0.0 1.4 1 0 0 1 1 1 1 Radical SAM superfamily WD40 PF00400.32 EGE00782.1 - 2.4e-11 44.0 3.8 2e-05 25.2 0.0 5.2 5 1 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EGE00782.1 - 0.0025 18.1 0.0 16 5.9 0.0 4.6 2 1 3 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.6 EGE00782.1 - 0.05 13.2 0.0 5.8 6.4 0.0 2.7 2 1 1 3 3 3 0 PQQ-like domain Oxysterol_BP PF01237.18 EGE00782.1 - 0.088 11.6 0.4 0.14 11.0 0.4 1.2 1 0 0 1 1 1 0 Oxysterol-binding protein PQQ_3 PF13570.6 EGE00782.1 - 0.1 13.1 0.0 13 6.4 0.0 3.5 4 0 0 4 4 4 0 PQQ-like domain Gryzun-like PF12742.7 EGE00782.1 - 0.13 12.3 0.0 0.29 11.1 0.0 1.5 1 0 0 1 1 1 0 Gryzun, putative Golgi trafficking DREPP PF05558.12 EGE00783.1 - 0.074 12.9 0.2 0.1 12.5 0.2 1.2 1 0 0 1 1 1 0 DREPP plasma membrane polypeptide Latrophilin PF02354.16 EGE00783.1 - 0.074 12.1 3.4 0.094 11.8 3.4 1.1 1 0 0 1 1 1 0 Latrophilin Cytoplasmic C-terminal region DeoC PF01791.9 EGE00784.1 - 7.4e-17 61.7 3.0 1.2e-16 61.1 3.0 1.3 1 0 0 1 1 1 1 DeoC/LacD family aldolase DHO_dh PF01180.21 EGE00784.1 - 0.00011 21.6 1.4 0.00015 21.1 1.4 1.3 1 0 0 1 1 1 1 Dihydroorotate dehydrogenase His_biosynth PF00977.21 EGE00784.1 - 0.014 14.9 0.5 0.028 13.9 0.5 1.5 1 0 0 1 1 1 0 Histidine biosynthesis protein FMN_dh PF01070.18 EGE00784.1 - 0.11 11.6 1.7 0.14 11.2 0.8 1.6 2 0 0 2 2 2 0 FMN-dependent dehydrogenase ComA PF02679.15 EGE00784.1 - 0.13 11.7 0.0 0.29 10.6 0.0 1.6 1 1 0 1 1 1 0 (2R)-phospho-3-sulfolactate synthase (ComA) SelK_SelG PF10961.8 EGE00785.1 - 3.3e-07 30.8 13.1 8.2e-06 26.4 13.1 2.1 1 1 0 1 1 1 1 Selenoprotein SelK_SelG TP_methylase PF00590.20 EGE00786.1 - 7.1e-45 153.6 0.0 1.1e-44 152.9 0.0 1.3 1 0 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases NAD_binding_7 PF13241.6 EGE00786.1 - 3.9e-13 49.7 0.0 7e-13 48.9 0.0 1.4 1 0 0 1 1 1 1 Putative NAD(P)-binding Sirohm_synth_C PF14823.6 EGE00786.1 - 4.2e-09 35.9 0.0 1.4e-05 24.7 0.0 2.3 2 0 0 2 2 2 2 Sirohaem biosynthesis protein C-terminal Sirohm_synth_M PF14824.6 EGE00786.1 - 7e-06 25.4 1.4 1e-05 24.9 0.2 2.0 2 0 0 2 2 2 1 Sirohaem biosynthesis protein central RRM_1 PF00076.22 EGE00787.1 - 7.3e-40 134.6 0.0 4.4e-17 61.7 0.0 4.0 3 1 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PknH_C PF14032.6 EGE00787.1 - 0.0045 16.9 1.1 13 5.5 0.0 3.2 3 0 0 3 3 3 2 PknH-like extracellular domain SPOR PF05036.13 EGE00787.1 - 0.0056 17.0 0.0 0.89 10.0 0.0 3.2 3 0 0 3 3 3 1 Sporulation related domain Limkain-b1 PF11608.8 EGE00787.1 - 0.009 16.1 0.1 24 5.1 0.0 3.9 4 1 0 4 4 4 2 Limkain b1 ATP-grasp_2 PF08442.10 EGE00787.1 - 0.012 15.2 0.0 0.084 12.4 0.0 2.2 2 0 0 2 2 2 0 ATP-grasp domain PH PF00169.29 EGE00788.1 - 0.00018 21.9 0.0 0.00039 20.9 0.0 1.6 1 0 0 1 1 1 1 PH domain DUF5344 PF17279.2 EGE00788.1 - 0.085 13.4 0.4 2.5 8.8 0.1 2.6 2 0 0 2 2 2 0 Family of unknown function (DUF5344) CHAD PF05235.14 EGE00788.1 - 0.089 12.8 0.8 1.1 9.1 0.1 2.4 2 0 0 2 2 2 0 CHAD domain Tim17 PF02466.19 EGE00789.1 - 3.3e-08 33.9 4.3 6.2e-08 33.0 4.3 1.5 1 1 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family DUF543 PF04418.12 EGE00789.1 - 0.16 12.0 0.9 1.1 9.3 0.9 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF543) RPT PF13446.6 EGE00790.1 - 5.4e-49 164.0 3.3 3.4e-18 65.3 0.0 4.4 4 0 0 4 4 4 4 A repeated domain in UCH-protein UCH PF00443.29 EGE00790.1 - 3.1e-10 40.0 0.1 5.1e-10 39.3 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EGE00790.1 - 0.00033 20.3 0.7 0.00048 19.8 0.1 1.6 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH PF00443.29 EGE00791.1 - 4.6e-31 108.3 0.4 6.2e-31 107.8 0.4 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Microvir_H PF04687.12 EGE00791.1 - 0.002 17.6 0.6 0.0034 16.8 0.6 1.3 1 0 0 1 1 1 1 Microvirus H protein (pilot protein) MFS_1 PF07690.16 EGE00792.1 - 2e-19 69.8 41.0 2e-19 69.8 41.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily CoA_trans PF01144.23 EGE00793.1 - 1.7e-104 348.0 2.0 1.4e-64 217.4 0.5 2.0 2 0 0 2 2 2 2 Coenzyme A transferase DUF2370 PF10176.9 EGE00795.1 - 3.9e-91 304.7 0.0 5.7e-91 304.2 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2370) DUF2561 PF10812.8 EGE00795.1 - 0.15 12.1 0.0 0.31 11.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2561) WSC PF01822.19 EGE00797.1 - 7.6e-09 35.6 8.0 1.3e-08 34.9 8.0 1.4 1 0 0 1 1 1 1 WSC domain SKG6 PF08693.10 EGE00797.1 - 0.99 8.9 5.6 2.4 7.6 5.6 1.6 1 0 0 1 1 1 0 Transmembrane alpha-helix domain CDP-OH_P_transf PF01066.21 EGE00799.1 - 1.7e-11 44.7 0.2 4.5e-11 43.4 0.0 1.8 2 0 0 2 2 2 1 CDP-alcohol phosphatidyltransferase Gar1 PF04410.14 EGE00800.1 - 5.7e-38 130.1 0.0 6.9e-38 129.8 0.0 1.0 1 0 0 1 1 1 1 Gar1/Naf1 RNA binding region tRNA-synt_2b PF00587.25 EGE00801.1 - 2.5e-30 105.8 0.0 1.2e-28 100.3 0.0 2.4 2 0 0 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 EGE00801.1 - 8.8e-16 57.8 0.1 1.7e-15 57.0 0.1 1.5 1 0 0 1 1 1 1 Anticodon binding domain TGS PF02824.21 EGE00801.1 - 0.0026 17.8 0.0 0.0071 16.4 0.0 1.7 1 0 0 1 1 1 1 TGS domain APH PF01636.23 EGE00802.1 - 8.6e-12 45.5 0.0 2e-11 44.3 0.0 1.6 1 1 0 1 1 1 1 Phosphotransferase enzyme family GAPT PF11770.8 EGE00802.1 - 0.16 11.8 0.3 0.31 10.9 0.3 1.4 1 0 0 1 1 1 0 GRB2-binding adapter (GAPT) RasGAP PF00616.19 EGE00803.1 - 2.1e-17 63.5 0.2 2.1e-08 34.1 0.0 3.3 1 1 1 2 2 2 2 GTPase-activator protein for Ras-like GTPase DNA_methylase PF00145.17 EGE00804.1 - 1.4e-32 113.4 0.0 2.7e-32 112.5 0.0 1.5 1 1 0 1 1 1 1 C-5 cytosine-specific DNA methylase BAH PF01426.18 EGE00804.1 - 5.6e-06 26.2 0.2 0.025 14.4 0.1 2.7 2 0 0 2 2 2 2 BAH domain DNMT1-RFD PF12047.8 EGE00804.1 - 0.035 14.1 0.1 0.15 12.1 0.0 2.1 2 0 0 2 2 2 0 Cytosine specific DNA methyltransferase replication foci domain WD40 PF00400.32 EGE00805.1 - 2.9e-08 34.3 0.2 1 10.3 0.0 4.2 4 0 0 4 4 4 3 WD domain, G-beta repeat UvrA_inter PF17760.1 EGE00806.1 - 0.18 11.9 0.0 0.38 10.8 0.0 1.5 1 0 0 1 1 1 0 UvrA interaction domain COQ9 PF08511.11 EGE00807.1 - 1.4e-25 88.8 0.5 3.3e-25 87.7 0.1 1.8 2 0 0 2 2 2 1 COQ9 Ost5 PF05251.12 EGE00808.1 - 0.012 15.9 1.6 0.012 15.9 1.6 2.1 2 0 0 2 2 2 0 Oligosaccharyltransferase subunit 5 AA_permease_2 PF13520.6 EGE00809.1 - 2.7e-55 187.9 49.0 3.2e-55 187.7 49.0 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EGE00809.1 - 3.1e-20 72.3 42.6 4.1e-20 71.8 42.6 1.1 1 0 0 1 1 1 1 Amino acid permease DUF3043 PF11241.8 EGE00809.1 - 5.2 7.1 6.5 11 6.0 0.3 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF3043) FmdA_AmdA PF03069.15 EGE00810.1 - 5.7e-59 199.8 0.0 2.2e-34 118.9 0.0 2.0 1 1 1 2 2 2 2 Acetamidase/Formamidase family Cyclin PF08613.11 EGE00811.1 - 2.9e-29 102.5 12.6 1.8e-19 70.6 0.6 4.8 3 1 1 4 4 4 2 Cyclin SUIM_assoc PF16619.5 EGE00811.1 - 0.005 16.9 23.2 0.0059 16.6 3.0 4.1 3 0 0 3 3 3 2 Unstructured region C-term to UIM in Ataxin3 DUF3484 PF11983.8 EGE00811.1 - 0.14 13.3 0.0 0.14 13.3 0.0 4.2 4 0 0 4 4 4 0 Membrane-attachment and polymerisation-promoting switch Zip PF02535.22 EGE00811.1 - 3.6 6.7 15.4 0.72 9.0 3.5 3.0 3 0 0 3 3 3 0 ZIP Zinc transporter DUF4834 PF16118.5 EGE00811.1 - 9.1 7.3 18.6 7.5 7.6 0.8 3.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) Proteasome PF00227.26 EGE00812.1 - 1.8e-45 154.7 0.3 2.1e-45 154.6 0.3 1.0 1 0 0 1 1 1 1 Proteasome subunit RabGAP-TBC PF00566.18 EGE00813.1 - 6.7e-28 97.8 0.0 1.5e-27 96.7 0.0 1.6 1 0 0 1 1 1 1 Rab-GTPase-TBC domain SBE2 PF17076.5 EGE00813.1 - 8.1e-08 31.0 0.4 8.1e-08 31.0 0.4 1.7 2 0 0 2 2 2 1 SBE2, cell-wall formation Telomerase_RBD PF12009.8 EGE00814.1 - 5.4e-48 162.5 0.0 1.2e-47 161.3 0.0 1.6 1 0 0 1 1 1 1 Telomerase ribonucleoprotein complex - RNA binding domain RVT_1 PF00078.27 EGE00814.1 - 1.1e-10 41.5 0.0 1.7e-06 27.7 0.0 2.5 2 0 0 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) RhoGEF PF00621.20 EGE00815.1 - 1.8e-36 126.1 0.0 5e-36 124.6 0.0 1.8 1 0 0 1 1 1 1 RhoGEF domain Lipoprotein_7 PF01540.16 EGE00815.1 - 0.34 10.1 1.1 9.2 5.4 0.0 2.2 2 0 0 2 2 2 0 Adhesin lipoprotein Peptidase_C48 PF02902.19 EGE00816.1 - 1.2e-13 51.4 0.6 5.3e-13 49.3 0.6 2.0 1 1 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain Alg14 PF08660.11 EGE00816.1 - 0.0037 17.2 0.4 0.0092 15.9 0.4 1.6 1 0 0 1 1 1 1 Oligosaccharide biosynthesis protein Alg14 like PrpF PF04303.13 EGE00817.1 - 1.3e-106 356.7 0.2 1.5e-106 356.5 0.2 1.0 1 0 0 1 1 1 1 PrpF protein tRNA-synt_1d PF00750.19 EGE00818.1 - 3.7e-87 292.5 0.3 6.6e-87 291.7 0.3 1.4 1 1 0 1 1 1 1 tRNA synthetases class I (R) DALR_1 PF05746.15 EGE00818.1 - 4.8e-28 97.7 0.2 2.8e-27 95.3 0.0 2.3 2 0 0 2 2 2 1 DALR anticodon binding domain Arg_tRNA_synt_N PF03485.16 EGE00818.1 - 0.044 14.4 0.1 0.13 12.8 0.1 1.8 1 0 0 1 1 1 0 Arginyl tRNA synthetase N terminal domain RRM_1 PF00076.22 EGE00821.1 - 9.3e-05 22.2 0.0 9.3e-05 22.2 0.0 2.1 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GramPos_pilinD1 PF16555.5 EGE00821.1 - 0.11 12.6 13.8 0.05 13.8 7.1 2.2 2 0 0 2 2 2 0 Gram-positive pilin subunit D1, N-terminal domain CMS1 PF14617.6 EGE00822.1 - 1.1e-72 244.5 1.7 2e-72 243.5 1.7 1.4 1 1 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit DEAD PF00270.29 EGE00822.1 - 0.00015 21.6 0.0 0.00018 21.4 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase CENP-T_C PF15511.6 EGE00823.1 - 2.7e-36 124.0 0.0 4.4e-36 123.3 0.0 1.3 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 EGE00823.1 - 4.5e-08 33.3 0.1 7.8e-08 32.6 0.1 1.3 1 0 0 1 1 1 1 CENP-S protein Histone PF00125.24 EGE00823.1 - 7.2e-05 23.2 0.2 0.00015 22.1 0.1 1.5 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EGE00823.1 - 0.00089 19.5 0.0 0.0014 18.9 0.0 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-X PF09415.10 EGE00823.1 - 0.15 12.4 0.3 0.44 10.9 0.0 1.8 2 0 0 2 2 2 0 CENP-S associating Centromere protein X SURF1 PF02104.15 EGE00824.1 - 2.6e-47 161.3 0.0 3.5e-47 160.9 0.0 1.1 1 0 0 1 1 1 1 SURF1 family UBX PF00789.20 EGE00825.1 - 3e-10 40.1 0.0 6.3e-10 39.1 0.0 1.5 1 0 0 1 1 1 1 UBX domain DUF3287 PF11690.8 EGE00825.1 - 0.13 12.0 1.8 0.26 11.0 1.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3287) DUF737 PF05300.11 EGE00825.1 - 0.47 10.8 15.4 1.1 9.6 15.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF737) CDC45 PF02724.14 EGE00825.1 - 7.2 4.8 11.6 14 3.8 11.6 1.4 1 0 0 1 1 1 0 CDC45-like protein DUF2076 PF09849.9 EGE00826.1 - 1.1e-08 35.5 12.5 1.3e-08 35.2 12.5 1.0 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2076) CHCH PF06747.13 EGE00826.1 - 1.5e-05 25.0 2.5 2.3e-05 24.4 2.5 1.3 1 0 0 1 1 1 1 CHCH domain CX9C PF16860.5 EGE00826.1 - 0.072 13.1 0.3 0.11 12.5 0.3 1.3 1 0 0 1 1 1 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, YppG PF14179.6 EGE00826.1 - 0.14 12.9 4.2 0.24 12.1 2.7 1.9 2 0 0 2 2 2 0 YppG-like protein Bindin PF02084.15 EGE00826.1 - 0.22 11.8 3.9 0.29 11.4 3.9 1.2 1 0 0 1 1 1 0 Bindin DUF3275 PF11679.8 EGE00826.1 - 1.8 8.5 6.0 1.6 8.7 2.6 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3275) Sas10_Utp3 PF04000.15 EGE00827.1 - 3.4e-18 66.1 0.9 3.4e-18 66.1 0.9 2.4 2 1 0 2 2 2 1 Sas10/Utp3/C1D family Merozoite_SPAM PF07133.11 EGE00827.1 - 0.53 10.2 23.5 1.1 9.2 23.5 1.5 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) SRP-alpha_N PF04086.13 EGE00827.1 - 1.5 8.7 23.5 2.1 8.2 23.5 1.3 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal CDC45 PF02724.14 EGE00827.1 - 9.1 4.4 19.7 12 4.1 19.7 1.2 1 0 0 1 1 1 0 CDC45-like protein ApbA_C PF08546.11 EGE00828.1 - 3.1e-31 108.2 0.1 4.7e-31 107.6 0.1 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal ApbA PF02558.16 EGE00828.1 - 6.1e-25 87.6 0.0 1.4e-23 83.2 0.0 2.2 1 1 0 1 1 1 1 Ketopantoate reductase PanE/ApbA Coq4 PF05019.13 EGE00829.1 - 1.6e-96 321.9 0.0 1.9e-96 321.7 0.0 1.0 1 0 0 1 1 1 1 Coenzyme Q (ubiquinone) biosynthesis protein Coq4 dsDNA_bind PF01984.20 EGE00830.1 - 1.7e-39 134.6 12.1 1.9e-39 134.4 12.1 1.0 1 0 0 1 1 1 1 Double-stranded DNA-binding domain Sec2p PF06428.11 EGE00831.1 - 2.4e-30 104.3 17.1 2.4e-30 104.3 17.1 2.4 3 0 0 3 3 3 1 GDP/GTP exchange factor Sec2p Tht1 PF04163.12 EGE00831.1 - 0.048 12.4 2.3 0.068 11.9 2.3 1.1 1 0 0 1 1 1 0 Tht1-like nuclear fusion protein DUF3584 PF12128.8 EGE00831.1 - 0.8 7.1 17.9 1.2 6.6 17.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Spc7 PF08317.11 EGE00831.1 - 1 8.1 16.5 1.8 7.4 16.5 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF4407 PF14362.6 EGE00831.1 - 1.1 8.5 12.6 2 7.7 12.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Nup54 PF13874.6 EGE00831.1 - 1.9 8.6 15.4 0.25 11.5 4.8 2.5 1 1 0 2 2 2 0 Nucleoporin complex subunit 54 V_ATPase_I PF01496.19 EGE00831.1 - 5.6 4.8 5.5 8.2 4.2 5.5 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family PRP21_like_P PF12230.8 EGE00832.1 - 7.3e-56 189.5 7.7 2e-30 106.3 2.1 2.2 2 0 0 2 2 2 2 Pre-mRNA splicing factor PRP21 like protein Surp PF01805.20 EGE00832.1 - 1.6e-36 124.1 3.0 9.3e-18 64.0 0.1 2.4 2 0 0 2 2 2 2 Surp module zf_UBZ PF18439.1 EGE00832.1 - 0.024 14.2 0.6 0.058 13.0 0.6 1.6 1 0 0 1 1 1 0 Ubiquitin-Binding Zinc Finger UPF0547 PF10571.9 EGE00832.1 - 0.24 11.5 1.5 0.85 9.8 1.5 1.9 1 0 0 1 1 1 0 Uncharacterised protein family UPF0547 Toprim_Crpt PF13342.6 EGE00832.1 - 0.68 10.0 1.9 7.4 6.6 0.5 2.4 2 0 0 2 2 2 0 C-terminal repeat of topoisomerase PMT PF02366.18 EGE00833.1 - 1.4e-76 257.4 15.4 1.4e-76 257.4 15.4 2.3 2 1 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 EGE00833.1 - 7.7e-65 218.2 18.4 7.7e-65 218.2 18.4 2.2 3 1 1 4 4 4 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 EGE00833.1 - 4e-46 157.2 0.0 6.9e-46 156.4 0.0 1.3 1 0 0 1 1 1 1 MIR domain Arteri_Gl PF00951.18 EGE00833.1 - 0.0094 15.8 2.2 0.021 14.7 2.2 1.5 1 0 0 1 1 1 1 Arterivirus GL envelope glycoprotein CCSMST1 PF15013.6 EGE00833.1 - 0.18 12.0 0.1 0.96 9.7 0.0 2.2 2 0 0 2 2 2 0 CCSMST1 family DHHC PF01529.20 EGE00834.1 - 6.7e-34 116.9 9.0 6.7e-34 116.9 9.0 1.7 2 0 0 2 2 2 1 DHHC palmitoyltransferase Yip1 PF04893.17 EGE00834.1 - 0.13 12.0 5.2 0.22 11.2 0.3 2.1 2 0 0 2 2 2 0 Yip1 domain SET PF00856.28 EGE00835.1 - 2.3e-14 54.2 1.5 3e-13 50.5 0.1 3.1 2 1 0 2 2 2 1 SET domain AWS PF17907.1 EGE00835.1 - 2.3e-07 30.8 10.0 2.3e-07 30.8 10.0 2.3 3 0 0 3 3 3 1 AWS domain DLH PF01738.18 EGE00836.1 - 4.4e-15 55.8 0.0 6.5e-15 55.3 0.0 1.3 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_1 PF00561.20 EGE00836.1 - 0.0094 15.6 0.0 0.036 13.7 0.0 1.8 2 0 0 2 2 2 1 alpha/beta hydrolase fold 14-3-3 PF00244.20 EGE00838.1 - 0.24 10.9 0.0 0.34 10.4 0.0 1.1 1 0 0 1 1 1 0 14-3-3 protein DUF1754 PF08555.10 EGE00840.1 - 1.7e-15 57.6 19.5 1.7e-15 57.6 19.5 1.4 2 0 0 2 2 2 1 Eukaryotic family of unknown function (DUF1754) CDC27 PF09507.10 EGE00840.1 - 0.047 13.1 15.6 0.052 12.9 15.6 1.0 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 EccE PF11203.8 EGE00840.1 - 0.2 12.0 3.5 0.12 12.7 1.2 1.6 1 1 1 2 2 2 0 Putative type VII ESX secretion system translocon, EccE LAM_C PF12544.8 EGE00840.1 - 0.23 11.6 3.2 0.33 11.1 3.2 1.2 1 0 0 1 1 1 0 Lysine-2,3-aminomutase G-gamma PF00631.22 EGE00840.1 - 0.56 10.2 2.5 0.73 9.9 0.5 2.1 2 0 0 2 2 2 0 GGL domain HSP70 PF00012.20 EGE00840.1 - 1.3 7.2 12.6 1.5 6.9 12.6 1.0 1 0 0 1 1 1 0 Hsp70 protein CDC45 PF02724.14 EGE00840.1 - 3.1 6.0 18.3 3.5 5.8 18.3 1.0 1 0 0 1 1 1 0 CDC45-like protein PTPA PF03095.15 EGE00841.1 - 1.5e-22 80.5 0.3 4.7e-22 78.8 0.2 1.6 1 1 1 2 2 2 2 Phosphotyrosyl phosphate activator (PTPA) protein DUF202 PF02656.15 EGE00843.1 - 5.8e-05 23.5 0.1 5.8e-05 23.5 0.1 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF202) DUF4187 PF13821.6 EGE00846.1 - 4.5e-12 45.6 0.1 9.5e-12 44.5 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4187) ARS2 PF04959.13 EGE00846.1 - 7.4e-11 42.8 2.9 7.4e-11 42.8 2.9 1.9 1 1 1 2 2 2 1 Arsenite-resistance protein 2 zf-C2H2_aberr PF17017.5 EGE00846.1 - 0.14 12.3 0.2 0.27 11.4 0.2 1.4 1 0 0 1 1 1 0 Aberrant zinc-finger TFIIA PF03153.13 EGE00848.1 - 2 8.3 27.5 2.1 8.3 27.5 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PepSY_TM PF03929.16 EGE00848.1 - 7.9 6.0 7.2 11 5.6 7.2 1.4 1 0 0 1 1 1 0 PepSY-associated TM region Kinesin PF00225.23 EGE00849.1 - 5.3e-112 374.0 0.0 7.9e-112 373.5 0.0 1.3 1 0 0 1 1 1 1 Kinesin motor domain DUF3694 PF12473.8 EGE00849.1 - 2.1e-45 155.1 0.0 6.1e-45 153.6 0.0 1.9 1 0 0 1 1 1 1 Kinesin protein Kinesin_assoc PF16183.5 EGE00849.1 - 5.5e-38 130.9 14.0 8.3e-32 110.8 0.4 4.0 4 1 1 5 5 5 2 Kinesin-associated Microtub_bd PF16796.5 EGE00849.1 - 3.6e-24 85.4 0.0 9.5e-24 84.0 0.0 1.7 1 0 0 1 1 1 1 Microtubule binding KIF1B PF12423.8 EGE00849.1 - 1e-07 32.2 0.2 4.4e-07 30.2 0.2 2.2 1 0 0 1 1 1 1 Kinesin protein 1B PH PF00169.29 EGE00849.1 - 0.00011 22.7 0.0 0.0004 20.8 0.0 2.0 2 0 0 2 2 2 1 PH domain FHA PF00498.26 EGE00849.1 - 0.00065 20.0 0.1 0.0044 17.3 0.1 2.5 2 0 0 2 2 2 1 FHA domain UPF0242 PF06785.11 EGE00849.1 - 1.3 9.1 5.8 0.38 10.8 0.8 2.3 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus 3-dmu-9_3-mt PF06983.13 EGE00850.1 - 4.6e-39 133.6 0.0 6.3e-39 133.1 0.0 1.2 1 0 0 1 1 1 1 3-demethylubiquinone-9 3-methyltransferase DSX_dimer PF08828.10 EGE00850.1 - 0.0097 15.6 0.1 0.021 14.5 0.1 1.6 1 0 0 1 1 1 1 Doublesex dimerisation domain Phosphodiest PF01663.22 EGE00851.1 - 9.6e-89 298.4 0.1 1.2e-88 298.1 0.1 1.1 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 EGE00851.1 - 0.00049 19.6 0.0 0.22 10.9 0.0 2.3 1 1 0 2 2 2 2 Sulfatase Metalloenzyme PF01676.18 EGE00851.1 - 0.00099 18.5 0.0 0.0017 17.8 0.0 1.2 1 0 0 1 1 1 1 Metalloenzyme superfamily PglZ PF08665.12 EGE00851.1 - 0.075 13.1 0.0 0.26 11.4 0.0 1.8 2 0 0 2 2 2 0 PglZ domain HNH_2 PF13391.6 EGE00852.1 - 1.8e-08 34.4 0.1 1.4e-07 31.5 0.0 2.3 2 0 0 2 2 2 1 HNH endonuclease MMTV_SAg PF01054.17 EGE00852.1 - 0.043 13.3 0.2 0.068 12.7 0.2 1.2 1 0 0 1 1 1 0 Mouse mammary tumour virus superantigen BRF1 PF07741.13 EGE00852.1 - 0.94 9.9 5.4 0.2 12.1 1.5 1.9 2 0 0 2 2 2 0 Brf1-like TBP-binding domain PHP_C PF13263.6 EGE00853.1 - 0.14 11.9 0.0 0.3 10.9 0.0 1.5 1 0 0 1 1 1 0 PHP-associated SNARE PF05739.19 EGE00856.1 - 0.24 11.4 6.3 0.45 10.6 6.3 1.3 1 0 0 1 1 1 0 SNARE domain Herpes_US9 PF06072.11 EGE00856.1 - 0.5 10.3 2.4 1.1 9.2 2.4 1.4 1 0 0 1 1 1 0 Alphaherpesvirus tegument protein US9 Prominin PF05478.11 EGE00856.1 - 4.8 5.0 8.8 6.7 4.5 8.8 1.0 1 0 0 1 1 1 0 Prominin DUF3723 PF12520.8 EGE00857.1 - 4.2e-17 62.0 0.1 8.1e-17 61.1 0.0 1.4 2 0 0 2 2 2 1 Protein of unknown function (DUF3723) GIDA_assoc PF13932.6 EGE00857.1 - 0.15 12.2 0.0 0.19 11.9 0.0 1.2 1 0 0 1 1 1 0 GidA associated domain APH PF01636.23 EGE00858.1 - 0.00042 20.3 0.0 0.00054 20.0 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family Fructosamin_kin PF03881.14 EGE00858.1 - 0.0091 15.2 0.0 0.011 14.9 0.0 1.1 1 0 0 1 1 1 1 Fructosamine kinase Pkinase PF00069.25 EGE00858.1 - 0.067 12.5 0.0 0.085 12.2 0.0 1.1 1 0 0 1 1 1 0 Protein kinase domain Peroxin-3 PF04882.12 EGE00860.1 - 7.6e-10 38.4 0.0 7.6e-10 38.4 0.0 1.1 1 0 0 1 1 1 1 Peroxin-3 Pkinase_fungal PF17667.1 EGE00861.1 - 7.1e-42 143.6 0.5 6.5e-29 100.9 0.1 2.0 1 1 1 2 2 2 2 Fungal protein kinase Pkinase PF00069.25 EGE00861.1 - 0.0021 17.5 0.0 0.0024 17.3 0.0 1.2 1 1 0 1 1 1 1 Protein kinase domain YrbL-PhoP_reg PF10707.9 EGE00861.1 - 0.089 12.3 0.0 0.13 11.8 0.0 1.2 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL RTC4 PF14474.6 EGE00865.1 - 1.7e-22 79.8 0.0 3.6e-22 78.8 0.0 1.5 1 0 0 1 1 1 1 RTC4-like domain zf-Di19 PF05605.12 EGE00865.1 - 0.11 12.8 2.0 0.2 12.0 0.0 2.3 3 0 0 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding AMP-binding PF00501.28 EGE00866.1 - 6.3e-73 245.8 0.0 1.9e-71 240.9 0.0 2.5 1 1 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EGE00866.1 - 0.00043 21.2 0.1 0.0011 20.0 0.1 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain LVIVD PF08309.11 EGE00867.1 - 0.00024 20.4 0.2 0.15 11.4 0.0 3.3 3 0 0 3 3 3 2 LVIVD repeat c-SKI_SMAD_bind PF08782.10 EGE00867.1 - 0.084 13.1 0.1 0.22 11.7 0.0 1.8 2 0 0 2 2 2 0 c-SKI Smad4 binding domain Methyltransf_16 PF10294.9 EGE00868.1 - 3.1e-09 36.8 0.1 0.00017 21.4 0.0 2.4 2 1 0 2 2 2 2 Lysine methyltransferase MIF4G PF02854.19 EGE00869.1 - 7.1e-53 179.4 0.0 1.1e-52 178.7 0.0 1.3 1 0 0 1 1 1 1 MIF4G domain eIF_4G1 PF12152.8 EGE00869.1 - 1.7e-25 89.0 2.3 4.5e-25 87.6 2.3 1.8 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 4G1 TB2_DP1_HVA22 PF03134.19 EGE00871.1 - 3e-23 81.5 9.1 4.6e-23 81.0 9.1 1.3 1 0 0 1 1 1 1 TB2/DP1, HVA22 family F-box-like PF12937.7 EGE00872.1 - 2.6e-05 24.0 0.1 5.8e-05 22.9 0.1 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EGE00872.1 - 0.00075 19.3 0.3 0.0019 18.0 0.3 1.7 1 0 0 1 1 1 1 F-box domain PRANC PF09372.10 EGE00872.1 - 0.071 13.4 0.2 0.18 12.1 0.2 1.6 1 0 0 1 1 1 0 PRANC domain Trypsin_2 PF13365.6 EGE00873.1 - 0.0011 19.9 0.0 0.0026 18.7 0.0 1.6 1 1 0 1 1 1 1 Trypsin-like peptidase domain Peptidase_S32 PF05579.13 EGE00873.1 - 0.0036 16.6 0.0 0.0052 16.0 0.0 1.2 1 0 0 1 1 1 1 Equine arteritis virus serine endopeptidase S32 LisH PF08513.11 EGE00877.1 - 4.8e-05 23.2 0.1 8.8e-05 22.3 0.1 1.5 1 0 0 1 1 1 1 LisH TRAPP PF04051.16 EGE00879.1 - 5.5e-35 120.2 0.0 6.7e-35 120.0 0.0 1.1 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component PNGaseA PF12222.8 EGE00879.1 - 0.0028 16.6 0.0 0.0032 16.4 0.0 1.1 1 0 0 1 1 1 1 Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A WD40 PF00400.32 EGE00880.1 - 3.1e-36 122.8 10.7 1.8e-05 25.4 0.0 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EGE00880.1 - 7.6e-10 39.0 0.1 0.019 15.3 0.0 4.3 2 1 4 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 EGE00880.1 - 0.055 12.2 0.9 1.9 7.1 0.0 2.3 1 1 0 2 2 2 0 Nup133 N terminal like Nup160 PF11715.8 EGE00880.1 - 0.12 11.0 0.5 2.6 6.6 0.2 2.4 1 1 1 2 2 2 0 Nucleoporin Nup120/160 US6 PF17616.2 EGE00881.1 - 0.08 12.9 0.5 0.13 12.2 0.5 1.2 1 0 0 1 1 1 0 Viral unique short region 6 Glyco_hydro_47 PF01532.20 EGE00882.1 - 9.4e-115 384.1 0.0 1.3e-114 383.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 DNA_pol_B_exo2 PF10108.9 EGE00882.1 - 0.012 15.3 0.0 0.021 14.5 0.0 1.3 1 0 0 1 1 1 0 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB Pribosyltran PF00156.27 EGE00883.1 - 3.8e-15 55.7 0.0 5.3e-15 55.3 0.0 1.2 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 EGE00883.1 - 0.02 14.3 0.0 0.029 13.8 0.0 1.2 1 0 0 1 1 1 0 Uracil phosphoribosyltransferase Glyco_hydro_42M PF08532.10 EGE00884.1 - 0.014 14.9 0.0 2 7.9 0.0 2.2 2 0 0 2 2 2 0 Beta-galactosidase trimerisation domain SlyX PF04102.12 EGE00886.1 - 0.05 14.2 2.2 0.15 12.7 0.4 2.5 3 0 0 3 3 3 0 SlyX RAP1 PF07218.11 EGE00886.1 - 1.3 7.2 5.8 1.6 6.9 5.8 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) HAD_2 PF13419.6 EGE00887.1 - 1.8e-06 28.2 0.0 3.3e-06 27.3 0.0 1.4 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EGE00887.1 - 0.0033 17.8 0.0 0.0044 17.3 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EGE00887.1 - 0.02 14.9 0.0 0.035 14.1 0.0 1.4 1 0 0 1 1 1 0 HAD-hyrolase-like Ribosomal_L5e PF17144.4 EGE00888.1 - 3.5e-80 267.7 0.2 5e-80 267.2 0.2 1.2 1 0 0 1 1 1 1 Ribosomal large subunit proteins 60S L5, and 50S L18 Ribosomal_L18_c PF14204.6 EGE00888.1 - 5.6e-34 117.0 2.8 5.6e-34 117.0 2.8 1.8 2 0 0 2 2 2 1 Ribosomal L18 C-terminal region DUF3135 PF11333.8 EGE00889.1 - 0.0017 18.6 0.3 0.087 13.1 0.1 2.7 2 0 0 2 2 2 1 Protein of unknown function (DUF3135) LRR_6 PF13516.6 EGE00889.1 - 0.0035 17.3 2.4 6.1 7.2 0.0 5.2 6 0 0 6 6 6 1 Leucine Rich repeat ABC_membrane_2 PF06472.15 EGE00890.1 - 1.6e-103 345.8 1.0 2.3e-103 345.3 1.0 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.27 EGE00890.1 - 2.6e-18 66.9 0.0 4.7e-18 66.0 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 EGE00890.1 - 7.7e-05 22.6 0.0 0.00017 21.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 EGE00890.1 - 0.0049 17.4 0.1 0.013 16.0 0.0 1.7 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 EGE00890.1 - 0.0089 15.8 0.0 0.041 13.6 0.0 2.0 2 0 0 2 2 2 1 P-loop containing region of AAA domain SMC_N PF02463.19 EGE00890.1 - 0.033 13.6 0.0 0.1 12.0 0.0 1.8 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 EGE00890.1 - 0.06 13.7 0.3 0.47 10.8 0.1 2.2 2 0 0 2 2 2 0 AAA ATPase domain Rad17 PF03215.15 EGE00890.1 - 0.099 12.6 0.0 0.25 11.3 0.0 1.6 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_15 PF13175.6 EGE00890.1 - 0.18 11.4 0.1 0.48 10.1 0.0 1.7 2 0 0 2 2 2 0 AAA ATPase domain RNA_helicase PF00910.22 EGE00890.1 - 0.19 12.1 0.0 0.42 11.0 0.0 1.6 1 0 0 1 1 1 0 RNA helicase p450 PF00067.22 EGE00891.1 - 2.1e-65 221.3 0.0 2.7e-65 220.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 APH PF01636.23 EGE00893.1 - 4.3e-14 53.0 0.1 1e-13 51.8 0.1 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pkinase PF00069.25 EGE00893.1 - 0.0054 16.1 0.1 0.38 10.1 0.0 2.4 2 0 0 2 2 2 2 Protein kinase domain Choline_kinase PF01633.20 EGE00893.1 - 0.0062 16.1 0.1 0.011 15.3 0.1 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase RIO1 PF01163.22 EGE00893.1 - 0.026 14.1 0.7 0.23 11.1 0.0 2.5 3 0 0 3 3 3 0 RIO1 family Phosphorylase PF00343.20 EGE00894.1 - 8.5e-138 460.7 0.0 1e-137 460.4 0.0 1.1 1 0 0 1 1 1 1 Carbohydrate phosphorylase DUF443 PF04276.12 EGE00896.1 - 0.12 12.1 0.0 0.16 11.7 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF443) Suc_Fer-like PF06999.12 EGE00897.1 - 1.8e-69 233.5 0.0 2.2e-69 233.3 0.0 1.1 1 0 0 1 1 1 1 Sucrase/ferredoxin-like APH PF01636.23 EGE00899.1 - 8.4e-12 45.5 0.0 1.2e-11 45.0 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EGE00899.1 - 0.00026 20.7 0.0 0.00065 19.3 0.0 1.8 1 1 0 1 1 1 1 Choline/ethanolamine kinase Fructosamin_kin PF03881.14 EGE00899.1 - 0.0061 15.8 0.0 0.011 14.9 0.0 1.3 1 0 0 1 1 1 1 Fructosamine kinase Pkinase PF00069.25 EGE00899.1 - 0.048 13.0 0.0 0.73 9.1 0.1 2.0 2 0 0 2 2 2 0 Protein kinase domain Exo_endo_phos_2 PF14529.6 EGE00900.1 - 5.5e-14 52.0 0.2 1e-12 47.9 0.1 2.8 2 1 0 2 2 2 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 EGE00900.1 - 0.0082 15.7 0.0 0.016 14.7 0.0 1.6 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Herpes_UL31 PF02718.14 EGE00900.1 - 0.083 11.9 0.4 0.14 11.2 0.4 1.2 1 0 0 1 1 1 0 Herpesvirus UL31-like protein CHAT PF12770.7 EGE00902.1 - 5.2e-31 108.1 0.0 7.3e-31 107.7 0.0 1.2 1 0 0 1 1 1 1 CHAT domain Peptidase_C50 PF03568.17 EGE00902.1 - 0.04 13.0 0.0 0.1 11.7 0.0 1.6 1 0 0 1 1 1 0 Peptidase family C50 TPR_12 PF13424.6 EGE00902.1 - 0.095 13.0 0.4 0.25 11.7 0.0 1.9 2 0 0 2 2 2 0 Tetratricopeptide repeat PTS_EIIC_2 PF13303.6 EGE00902.1 - 0.35 9.8 0.9 0.53 9.3 0.9 1.1 1 0 0 1 1 1 0 Phosphotransferase system, EIIC TPR_12 PF13424.6 EGE00904.1 - 1.4e-05 25.3 7.5 0.011 16.0 0.8 3.6 2 2 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 EGE00904.1 - 1.4e-05 24.8 0.2 2 8.8 0.1 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 EGE00904.1 - 0.00045 20.8 4.4 0.006 17.2 2.8 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_10 PF13374.6 EGE00904.1 - 0.00079 19.2 2.5 5.1 7.1 0.1 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_MalT PF17874.1 EGE00904.1 - 0.0052 16.2 2.5 0.021 14.2 2.2 1.9 1 1 1 2 2 2 1 MalT-like TPR region TPR_1 PF00515.28 EGE00904.1 - 0.0073 16.1 0.2 9.5 6.2 0.0 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_4 PF07721.14 EGE00904.1 - 0.0077 16.8 4.6 0.66 10.8 0.2 3.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 EGE00904.1 - 0.012 16.1 5.2 0.078 13.5 3.5 2.7 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.6 EGE00904.1 - 0.074 13.1 2.7 19 5.5 0.3 3.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 EGE00904.1 - 0.76 10.8 7.1 1.9 9.5 0.6 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat APH PF01636.23 EGE00906.1 - 1.2e-14 54.9 0.2 1.6e-14 54.5 0.2 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EGE00906.1 - 4.2e-05 23.2 0.0 6.9e-05 22.5 0.0 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase Ank_4 PF13637.6 EGE00907.1 - 2.2e-69 229.0 5.8 4.3e-13 49.5 0.0 6.3 3 2 5 8 8 8 7 Ankyrin repeats (many copies) Ank_2 PF12796.7 EGE00907.1 - 2.1e-62 207.7 1.4 8.3e-19 68.0 0.0 5.3 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EGE00907.1 - 1.2e-56 182.0 2.7 0.00012 22.2 0.0 10.2 11 0 0 11 11 11 9 Ankyrin repeat Ank PF00023.30 EGE00907.1 - 4.9e-54 178.5 6.0 1.2e-06 28.6 0.0 9.5 9 0 0 9 9 9 9 Ankyrin repeat Ank_5 PF13857.6 EGE00907.1 - 9.5e-40 134.2 0.4 3.6e-08 33.5 0.0 7.2 3 2 6 9 9 9 8 Ankyrin repeats (many copies) F-box-like PF12937.7 EGE00907.1 - 4.8e-06 26.4 0.1 8.4e-06 25.6 0.1 1.4 1 0 0 1 1 1 1 F-box-like His_Me_b4a2 PF18275.1 EGE00907.1 - 0.00046 20.2 0.0 61 3.8 0.0 5.0 5 0 0 5 5 5 0 His-Me finger endonuclease beta4-alpha2 domain TPR_20 PF14561.6 EGE00907.1 - 0.0049 17.2 0.0 0.81 10.1 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat VWA_3_C PF18571.1 EGE00907.1 - 0.072 13.0 7.7 1.2 9.1 0.0 4.7 5 0 0 5 5 5 0 von Willebrand factor type A C-terminal domain F-box PF00646.33 EGE00907.1 - 0.15 12.0 0.0 0.3 11.0 0.0 1.5 1 0 0 1 1 1 0 F-box domain Myb_DNA-binding PF00249.31 EGE00908.1 - 0.02 15.0 0.0 0.046 13.9 0.0 1.6 1 0 0 1 1 1 0 Myb-like DNA-binding domain Mei5 PF10376.9 EGE00909.1 - 1.3e-07 31.7 3.9 9.3e-05 22.4 3.9 2.2 1 1 0 1 1 1 1 Double-strand recombination repair protein DUF4140 PF13600.6 EGE00909.1 - 0.086 13.3 0.1 0.086 13.3 0.1 2.4 2 1 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) Dermcidin PF15291.6 EGE00909.1 - 0.13 12.8 0.4 6.2 7.4 0.0 2.3 2 0 0 2 2 2 0 Dermcidin, antibiotic peptide Dus PF01207.17 EGE00912.1 - 1.8e-42 145.5 0.0 5.3e-30 104.6 0.0 2.6 2 1 0 2 2 2 2 Dihydrouridine synthase (Dus) zf-CCCH PF00642.24 EGE00912.1 - 0.00049 19.9 2.9 0.03 14.2 0.4 2.7 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 EGE00912.1 - 0.0025 17.8 7.2 0.076 13.1 1.8 2.7 2 0 0 2 2 2 2 Zinc finger domain zf-CCCH_4 PF18044.1 EGE00912.1 - 0.0053 16.5 1.0 0.0053 16.5 1.0 3.3 3 0 0 3 3 3 1 CCCH-type zinc finger Kelch_4 PF13418.6 EGE00913.1 - 2.3e-27 94.7 5.8 9.2e-07 28.8 0.0 4.8 4 0 0 4 4 4 4 Galactose oxidase, central domain Kelch_5 PF13854.6 EGE00913.1 - 5.2e-25 87.0 0.2 1.1e-05 25.3 0.0 4.6 4 0 0 4 4 4 4 Kelch motif Kelch_2 PF07646.15 EGE00913.1 - 4.7e-23 80.2 1.4 4.2e-07 29.7 0.1 4.5 4 0 0 4 4 4 4 Kelch motif Kelch_6 PF13964.6 EGE00913.1 - 9.1e-23 79.7 3.5 9.4e-06 25.7 0.0 5.3 4 1 1 5 5 5 4 Kelch motif Kelch_1 PF01344.25 EGE00913.1 - 3.6e-21 74.5 1.9 6.9e-06 25.5 0.1 4.8 5 0 0 5 5 5 4 Kelch motif Kelch_3 PF13415.6 EGE00913.1 - 1.2e-20 73.3 13.1 1.7e-07 31.3 0.0 6.1 6 0 0 6 6 6 4 Galactose oxidase, central domain BTB PF00651.31 EGE00913.1 - 5.3e-08 33.1 0.0 9.3e-08 32.3 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain Choline_kinase PF01633.20 EGE00914.1 - 7.1e-06 25.8 1.0 1.2e-05 25.0 1.0 1.4 1 0 0 1 1 1 1 Choline/ethanolamine kinase APH PF01636.23 EGE00914.1 - 1.1e-05 25.4 0.1 1.5e-05 25.0 0.1 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.20 EGE00914.1 - 0.00088 18.7 0.0 0.001 18.4 0.0 1.1 1 0 0 1 1 1 1 Ecdysteroid kinase DUF1679 PF07914.11 EGE00914.1 - 0.077 11.8 0.0 0.095 11.5 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1679) ANAPC4_WD40 PF12894.7 EGE00915.1 - 6.8e-16 58.3 2.7 8.5e-06 26.0 0.1 4.3 2 1 3 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EGE00915.1 - 1.6e-15 57.2 15.5 0.00047 20.9 0.1 6.3 6 0 0 6 6 6 5 WD domain, G-beta repeat Ge1_WD40 PF16529.5 EGE00915.1 - 1.5e-05 24.2 0.0 0.00091 18.3 0.0 3.0 2 1 2 4 4 4 1 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 EGE00915.1 - 0.00045 20.2 0.3 0.025 14.4 0.1 2.4 1 1 1 2 2 2 1 Eukaryotic translation initiation factor eIF2A RRS1 PF04939.12 EGE00916.1 - 1.8e-31 109.2 13.7 2.2e-31 108.9 13.7 1.1 1 0 0 1 1 1 1 Ribosome biogenesis regulatory protein (RRS1) Ribosomal_L41 PF05162.13 EGE00916.1 - 0.034 14.2 5.7 0.034 14.2 5.7 2.7 2 0 0 2 2 2 0 Ribosomal protein L41 RhoGAP PF00620.27 EGE00917.1 - 1e-27 96.8 0.0 1.7e-27 96.1 0.0 1.3 1 0 0 1 1 1 1 RhoGAP domain Prenyltrans PF00432.21 EGE00919.1 - 7.7e-58 191.9 5.0 1.3e-11 44.0 0.0 6.2 6 0 0 6 6 6 6 Prenyltransferase and squalene oxidase repeat SQHop_cyclase_N PF13249.6 EGE00919.1 - 9.3e-08 31.5 0.0 0.0045 16.1 0.0 4.1 2 1 2 4 4 4 3 Squalene-hopene cyclase N-terminal domain SQHop_cyclase_C PF13243.6 EGE00919.1 - 0.00029 20.1 1.0 0.039 13.1 0.1 2.9 1 1 2 3 3 3 2 Squalene-hopene cyclase C-terminal domain Peptidase_S8 PF00082.22 EGE00924.1 - 1e-32 113.6 1.8 1.3e-32 113.3 1.8 1.1 1 0 0 1 1 1 1 Subtilase family RSN1_7TM PF02714.15 EGE00926.1 - 7.3e-51 173.1 24.6 3.9e-46 157.6 16.4 3.1 1 1 1 2 2 2 2 Calcium-dependent channel, 7TM region, putative phosphate PHM7_cyt PF14703.6 EGE00926.1 - 4.9e-05 23.6 0.1 7.2e-05 23.1 0.1 1.2 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter DUF3981 PF13139.6 EGE00926.1 - 0.31 11.4 2.6 1 9.8 2.6 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF3981) DUF1774 PF08611.10 EGE00926.1 - 2.6 8.4 7.0 3.1 8.2 1.5 2.9 2 0 0 2 2 2 0 Fungal protein of unknown function (DUF1774) MFS_1 PF07690.16 EGE00927.1 - 9.8e-09 34.6 7.1 0.0012 17.8 9.3 2.0 2 0 0 2 2 2 2 Major Facilitator Superfamily DUF4282 PF14110.6 EGE00927.1 - 0.24 12.1 5.6 9 7.1 4.2 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4282) DUF2628 PF10947.8 EGE00927.1 - 2.6 8.4 4.9 27 5.2 0.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2628) TssN PF17555.2 EGE00927.1 - 6.2 6.1 6.0 6.8 6.0 4.9 1.8 1 1 0 2 2 2 0 Type VI secretion system, TssN Bac_GDH PF05088.12 EGE00928.1 - 1.6e-14 52.5 0.0 2e-14 52.2 0.0 1.0 1 0 0 1 1 1 1 Bacterial NAD-glutamate dehydrogenase ELFV_dehydrog_N PF02812.18 EGE00928.1 - 0.086 12.7 0.0 0.17 11.7 0.0 1.4 1 0 0 1 1 1 0 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain Ist1 PF03398.14 EGE00928.1 - 0.1 12.5 0.0 0.35 10.8 0.0 1.8 2 0 0 2 2 2 0 Regulator of Vps4 activity in the MVB pathway DUF3546 PF12066.8 EGE00929.1 - 1.7e-31 108.7 0.4 1.7e-31 108.7 0.4 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF3546) HATPase_c PF02518.26 EGE00931.1 - 0.00048 20.6 0.0 0.00071 20.1 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Integrase_H2C2 PF17921.1 EGE00934.1 - 0.00035 20.6 0.7 0.00055 20.0 0.1 1.7 2 0 0 2 2 2 1 Integrase zinc binding domain RSN1_TM PF13967.6 EGE00936.1 - 6.8e-34 116.9 0.4 7.5e-34 116.7 0.4 1.0 1 0 0 1 1 1 1 Late exocytosis, associated with Golgi transport HD PF01966.22 EGE00938.1 - 0.0024 18.1 0.1 0.0047 17.1 0.1 1.5 1 1 0 1 1 1 1 HD domain zf-H2C2_2 PF13465.6 EGE00939.1 - 1.3e-06 28.6 12.6 7.2e-06 26.2 1.4 3.1 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_jaz PF12171.8 EGE00939.1 - 0.00031 21.0 4.8 0.037 14.3 1.2 2.7 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.12 EGE00939.1 - 0.00032 20.9 7.0 0.00058 20.1 6.8 1.6 1 1 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_4 PF13894.6 EGE00939.1 - 0.00068 20.3 19.1 0.008 16.9 5.6 3.0 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2 PF00096.26 EGE00939.1 - 0.0055 17.1 14.5 0.054 14.0 7.1 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-met PF12874.7 EGE00939.1 - 0.15 12.5 5.0 2 8.9 0.8 2.7 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-C2HC_2 PF13913.6 EGE00939.1 - 4 7.4 9.2 3 7.9 1.4 2.4 2 0 0 2 2 2 0 zinc-finger of a C2HC-type QCR10 PF09796.9 EGE00940.1 - 6.7e-27 93.3 0.1 8.1e-27 93.1 0.1 1.1 1 0 0 1 1 1 1 Ubiquinol-cytochrome-c reductase complex subunit (QCR10) zf-CCCH_6 PF18585.1 EGE00942.1 - 6.9e-26 89.9 0.9 1.5e-25 88.8 0.9 1.6 1 0 0 1 1 1 1 Chromatin remodeling factor Mit1 C-terminal Zn finger 2 Helicase_C PF00271.31 EGE00942.1 - 1.1e-12 48.2 0.0 2.2e-12 47.3 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain APH PF01636.23 EGE00943.1 - 0.00021 21.3 0.1 0.00023 21.2 0.1 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.20 EGE00943.1 - 0.072 12.4 0.0 0.094 12.0 0.0 1.2 1 0 0 1 1 1 0 Ecdysteroid kinase # # Program: hmmscan # Version: 3.2.1 (June 2018) # Pipeline mode: SCAN # Query file: /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Trichophyton_tonsurans_CBS_112818-ASM15145v1/GCA_000151455.1_ASM15145v1_protein.faa # Target file: /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm # Option settings: /oak/stanford/groups/akundaje/marinovg/programs/hmmer-3.2.1/bin/hmmscan -o /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Trichophyton_tonsurans_CBS_112818-ASM15145v1/GCA_000151455.1_ASM15145v1_protein.PFam32-A --tblout /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Trichophyton_tonsurans_CBS_112818-ASM15145v1/GCA_000151455.1_ASM15145v1_protein.PFam32-A.tblout --cpu 20 /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Trichophyton_tonsurans_CBS_112818-ASM15145v1/GCA_000151455.1_ASM15145v1_protein.faa # Current dir: /oak/stanford/groups/akundaje/marinovg/genomes # Date: Mon Mar 25 07:41:07 2019 # [ok]